Mitch Report

date generated: 2020-12-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                  skel         heart
##           393.8656285 -1266.6296855
## 5_8S_rRNA   4.2647989   -15.7563198
## A1BG       -0.4250025    -1.6154658
## A1CF        0.9452369     0.2527996
## A2M        -0.4893072    -0.8454735
## A3GALT2    -0.6719394     0.2338010

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	17470
duplicated_genes_present	0
num_profile_genes_in_sets	9239
num_profile_genes_not_in_sets	8231
profile_pearson_correl	-0.8948
profile_spearman_correl	-0.02908

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2408
num_genesets_excluded	966
num_genesets_included	1442

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 260

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.skel	s.heart	p.skel	p.heart
Translation	261	5.96e-22	8.16e-19	0.3520	0.14300	0.3210	7.11e-05	4.27e-19
Mitochondrial translation elongation	85	1.13e-21	8.16e-19	0.6110	0.17400	0.5850	5.51e-03	1.02e-20
Mitochondrial translation	91	3.60e-21	1.73e-18	0.5840	0.15400	0.5630	1.14e-02	1.57e-20
Mitochondrial translation termination	85	6.43e-21	2.32e-18	0.6000	0.17400	0.5740	5.46e-03	5.85e-20
Mitochondrial translation initiation	85	5.60e-20	1.61e-17	0.5850	0.19100	0.5530	2.32e-03	1.20e-18
The citric acid (TCA) cycle and respiratory electron transport	164	6.83e-13	1.64e-10	0.3360	0.08100	0.3260	7.37e-02	5.49e-13
Macroautophagy	108	4.64e-11	9.56e-09	0.3840	-0.01260	0.3840	8.21e-01	5.26e-12
Metabolism of proteins	1803	1.01e-10	1.83e-08	0.0965	0.02970	0.0918	3.86e-02	1.58e-10
Autophagy	122	1.77e-10	2.83e-08	0.3520	-0.04480	0.3500	3.93e-01	2.57e-11
Xenobiotics	20	3.53e-10	5.09e-08	0.8400	-0.67600	-0.4990	1.67e-07	1.13e-04
Protein localization	156	4.73e-10	6.20e-08	0.3050	-0.01830	0.3040	6.94e-01	5.75e-11
Respiratory electron transport	95	1.47e-09	1.76e-07	0.3750	0.14900	0.3440	1.20e-02	7.20e-09
Metabolism	1930	8.45e-09	9.37e-07	0.0856	-0.02630	0.0815	5.95e-02	4.89e-09
Defective CFTR causes cystic fibrosis	58	1.48e-08	1.53e-06	0.4540	0.05990	0.4500	4.30e-01	3.09e-09
tRNA Aminoacylation	41	1.99e-08	1.90e-06	0.5320	0.21100	0.4880	1.94e-02	6.44e-08
Extracellular matrix organization	271	2.11e-08	1.90e-06	0.2130	0.12500	-0.1720	3.98e-04	1.09e-06
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	116	2.81e-08	2.33e-06	0.3140	0.12400	0.2880	2.16e-02	8.25e-08
ABC transporter disorders	74	2.91e-08	2.33e-06	0.3950	0.03240	0.3940	6.30e-01	4.77e-09
Selective autophagy	56	4.62e-08	3.46e-06	0.4520	-0.11300	0.4380	1.44e-01	1.47e-08
ABC-family proteins mediated transport	97	4.80e-08	3.46e-06	0.3390	0.07220	0.3310	2.19e-01	1.74e-08
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	53	1.66e-07	1.14e-05	0.4420	0.05540	0.4380	4.85e-01	3.36e-08
Fatty acids	14	1.93e-07	1.27e-05	0.8460	-0.70900	-0.4630	4.38e-06	2.71e-03
Hh mutants abrogate ligand secretion	56	2.12e-07	1.33e-05	0.4270	0.04540	0.4240	5.57e-01	3.96e-08
Mitochondrial protein import	62	2.59e-07	1.56e-05	0.4010	0.13000	0.3790	7.75e-02	2.43e-07
Interleukin-1 signaling	94	3.54e-07	2.04e-05	0.3250	0.00520	0.3250	9.31e-01	5.17e-08
NIK-->noncanonical NF-kB signaling	56	3.85e-07	2.14e-05	0.4170	0.08210	0.4090	2.88e-01	1.18e-07
Regulation of ornithine decarboxylase (ODC)	49	4.88e-07	2.52e-05	0.4430	0.06440	0.4380	4.35e-01	1.10e-07
GPCR downstream signalling	706	4.90e-07	2.52e-05	0.1180	-0.07310	-0.0924	9.85e-04	3.08e-05
Metabolism of polyamines	57	5.62e-07	2.70e-05	0.4080	0.08520	0.3990	2.66e-01	1.85e-07
Cross-presentation of soluble exogenous antigens (endosomes)	48	5.75e-07	2.70e-05	0.4440	0.09350	0.4340	2.62e-01	1.91e-07
Signaling by GPCR	772	5.92e-07	2.70e-05	0.1120	-0.06530	-0.0912	2.12e-03	1.76e-05
Collagen formation	80	5.98e-07	2.70e-05	0.3510	0.29200	-0.1950	6.41e-06	2.62e-03
Regulation of Apoptosis	50	6.30e-07	2.75e-05	0.4340	0.07490	0.4280	3.60e-01	1.64e-07
AUF1 (hnRNP D0) binds and destabilizes mRNA	51	7.36e-07	3.06e-05	0.4300	-0.00537	0.4300	9.47e-01	1.07e-07
Degradation of GLI2 by the proteasome	55	7.42e-07	3.06e-05	0.4130	0.04060	0.4110	6.03e-01	1.36e-07
Vpu mediated degradation of CD4	49	8.63e-07	3.46e-05	0.4340	0.07550	0.4270	3.61e-01	2.27e-07
Pyruvate metabolism and Citric Acid (TCA) cycle	52	1.10e-06	4.27e-05	0.4200	-0.01920	0.4200	8.11e-01	1.63e-07
Collagen biosynthesis and modifying enzymes	58	1.13e-06	4.27e-05	0.4030	0.33700	-0.2210	9.22e-06	3.66e-03
Vif-mediated degradation of APOBEC3G	50	1.27e-06	4.70e-05	0.4250	0.03480	0.4230	6.71e-01	2.23e-07
Mitochondrial Fatty Acid Beta-Oxidation	36	1.33e-06	4.73e-05	0.5000	0.01650	0.5000	8.64e-01	2.08e-07
Degradation of GLI1 by the proteasome	56	1.34e-06	4.73e-05	0.4010	0.02430	0.4000	7.53e-01	2.23e-07
Interleukin-1 family signaling	127	1.38e-06	4.74e-05	0.2650	0.05460	0.2600	2.88e-01	4.37e-07
Regulation of activated PAK-2p34 by proteasome mediated degradation	47	1.55e-06	5.19e-05	0.4340	0.06380	0.4290	4.49e-01	3.53e-07
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	52	1.61e-06	5.29e-05	0.4130	0.04050	0.4110	6.13e-01	3.01e-07
Cell surface interactions at the vascular wall	152	1.83e-06	5.85e-05	0.2400	-0.03760	-0.2380	4.24e-01	4.38e-07
Regulation of RUNX2 expression and activity	69	1.89e-06	5.85e-05	0.3550	0.08360	0.3450	2.30e-01	7.24e-07
Complex I biogenesis	53	1.91e-06	5.85e-05	0.4030	0.19100	0.3550	1.64e-02	8.01e-06
Deubiquitination	231	2.07e-06	6.22e-05	0.1960	-0.02780	0.1940	4.67e-01	3.71e-07
SCF-beta-TrCP mediated degradation of Emi1	52	2.15e-06	6.33e-05	0.4070	0.06700	0.4020	4.03e-01	5.35e-07
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	63	2.25e-06	6.50e-05	0.3720	-0.01940	0.3710	7.90e-01	3.43e-07

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.skel	s.heart	p.skel	p.heart
Translation	261	5.96e-22	8.16e-19	0.35200	1.43e-01	3.21e-01	7.11e-05	4.27e-19
Mitochondrial translation elongation	85	1.13e-21	8.16e-19	0.61100	1.74e-01	5.85e-01	5.51e-03	1.02e-20
Mitochondrial translation	91	3.60e-21	1.73e-18	0.58400	1.54e-01	5.63e-01	1.14e-02	1.57e-20
Mitochondrial translation termination	85	6.43e-21	2.32e-18	0.60000	1.74e-01	5.74e-01	5.46e-03	5.85e-20
Mitochondrial translation initiation	85	5.60e-20	1.61e-17	0.58500	1.91e-01	5.53e-01	2.32e-03	1.20e-18
The citric acid (TCA) cycle and respiratory electron transport	164	6.83e-13	1.64e-10	0.33600	8.10e-02	3.26e-01	7.37e-02	5.49e-13
Macroautophagy	108	4.64e-11	9.56e-09	0.38400	-1.26e-02	3.84e-01	8.21e-01	5.26e-12
Metabolism of proteins	1803	1.01e-10	1.83e-08	0.09650	2.97e-02	9.18e-02	3.86e-02	1.58e-10
Autophagy	122	1.77e-10	2.83e-08	0.35200	-4.48e-02	3.50e-01	3.93e-01	2.57e-11
Xenobiotics	20	3.53e-10	5.09e-08	0.84000	-6.76e-01	-4.99e-01	1.67e-07	1.13e-04
Protein localization	156	4.73e-10	6.20e-08	0.30500	-1.83e-02	3.04e-01	6.94e-01	5.75e-11
Respiratory electron transport	95	1.47e-09	1.76e-07	0.37500	1.49e-01	3.44e-01	1.20e-02	7.20e-09
Metabolism	1930	8.45e-09	9.37e-07	0.08560	-2.63e-02	8.15e-02	5.95e-02	4.89e-09
Defective CFTR causes cystic fibrosis	58	1.48e-08	1.53e-06	0.45400	5.99e-02	4.50e-01	4.30e-01	3.09e-09
tRNA Aminoacylation	41	1.99e-08	1.90e-06	0.53200	2.11e-01	4.88e-01	1.94e-02	6.44e-08
Extracellular matrix organization	271	2.11e-08	1.90e-06	0.21300	1.25e-01	-1.72e-01	3.98e-04	1.09e-06
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	116	2.81e-08	2.33e-06	0.31400	1.24e-01	2.88e-01	2.16e-02	8.25e-08
ABC transporter disorders	74	2.91e-08	2.33e-06	0.39500	3.24e-02	3.94e-01	6.30e-01	4.77e-09
Selective autophagy	56	4.62e-08	3.46e-06	0.45200	-1.13e-01	4.38e-01	1.44e-01	1.47e-08
ABC-family proteins mediated transport	97	4.80e-08	3.46e-06	0.33900	7.22e-02	3.31e-01	2.19e-01	1.74e-08
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	53	1.66e-07	1.14e-05	0.44200	5.54e-02	4.38e-01	4.85e-01	3.36e-08
Fatty acids	14	1.93e-07	1.27e-05	0.84600	-7.09e-01	-4.63e-01	4.38e-06	2.71e-03
Hh mutants abrogate ligand secretion	56	2.12e-07	1.33e-05	0.42700	4.54e-02	4.24e-01	5.57e-01	3.96e-08
Mitochondrial protein import	62	2.59e-07	1.56e-05	0.40100	1.30e-01	3.79e-01	7.75e-02	2.43e-07
Interleukin-1 signaling	94	3.54e-07	2.04e-05	0.32500	5.20e-03	3.25e-01	9.31e-01	5.17e-08
NIK-->noncanonical NF-kB signaling	56	3.85e-07	2.14e-05	0.41700	8.21e-02	4.09e-01	2.88e-01	1.18e-07
Regulation of ornithine decarboxylase (ODC)	49	4.88e-07	2.52e-05	0.44300	6.44e-02	4.38e-01	4.35e-01	1.10e-07
GPCR downstream signalling	706	4.90e-07	2.52e-05	0.11800	-7.31e-02	-9.24e-02	9.85e-04	3.08e-05
Metabolism of polyamines	57	5.62e-07	2.70e-05	0.40800	8.52e-02	3.99e-01	2.66e-01	1.85e-07
Cross-presentation of soluble exogenous antigens (endosomes)	48	5.75e-07	2.70e-05	0.44400	9.35e-02	4.34e-01	2.62e-01	1.91e-07
Signaling by GPCR	772	5.92e-07	2.70e-05	0.11200	-6.53e-02	-9.12e-02	2.12e-03	1.76e-05
Collagen formation	80	5.98e-07	2.70e-05	0.35100	2.92e-01	-1.95e-01	6.41e-06	2.62e-03
Regulation of Apoptosis	50	6.30e-07	2.75e-05	0.43400	7.49e-02	4.28e-01	3.60e-01	1.64e-07
AUF1 (hnRNP D0) binds and destabilizes mRNA	51	7.36e-07	3.06e-05	0.43000	-5.37e-03	4.30e-01	9.47e-01	1.07e-07
Degradation of GLI2 by the proteasome	55	7.42e-07	3.06e-05	0.41300	4.06e-02	4.11e-01	6.03e-01	1.36e-07
Vpu mediated degradation of CD4	49	8.63e-07	3.46e-05	0.43400	7.55e-02	4.27e-01	3.61e-01	2.27e-07
Pyruvate metabolism and Citric Acid (TCA) cycle	52	1.10e-06	4.27e-05	0.42000	-1.92e-02	4.20e-01	8.11e-01	1.63e-07
Collagen biosynthesis and modifying enzymes	58	1.13e-06	4.27e-05	0.40300	3.37e-01	-2.21e-01	9.22e-06	3.66e-03
Vif-mediated degradation of APOBEC3G	50	1.27e-06	4.70e-05	0.42500	3.48e-02	4.23e-01	6.71e-01	2.23e-07
Mitochondrial Fatty Acid Beta-Oxidation	36	1.33e-06	4.73e-05	0.50000	1.65e-02	5.00e-01	8.64e-01	2.08e-07
Degradation of GLI1 by the proteasome	56	1.34e-06	4.73e-05	0.40100	2.43e-02	4.00e-01	7.53e-01	2.23e-07
Interleukin-1 family signaling	127	1.38e-06	4.74e-05	0.26500	5.46e-02	2.60e-01	2.88e-01	4.37e-07
Regulation of activated PAK-2p34 by proteasome mediated degradation	47	1.55e-06	5.19e-05	0.43400	6.38e-02	4.29e-01	4.49e-01	3.53e-07
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	52	1.61e-06	5.29e-05	0.41300	4.05e-02	4.11e-01	6.13e-01	3.01e-07
Cell surface interactions at the vascular wall	152	1.83e-06	5.85e-05	0.24000	-3.76e-02	-2.38e-01	4.24e-01	4.38e-07
Regulation of RUNX2 expression and activity	69	1.89e-06	5.85e-05	0.35500	8.36e-02	3.45e-01	2.30e-01	7.24e-07
Complex I biogenesis	53	1.91e-06	5.85e-05	0.40300	1.91e-01	3.55e-01	1.64e-02	8.01e-06
Deubiquitination	231	2.07e-06	6.22e-05	0.19600	-2.78e-02	1.94e-01	4.67e-01	3.71e-07
SCF-beta-TrCP mediated degradation of Emi1	52	2.15e-06	6.33e-05	0.40700	6.70e-02	4.02e-01	4.03e-01	5.35e-07
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	63	2.25e-06	6.50e-05	0.37200	-1.94e-02	3.71e-01	7.90e-01	3.43e-07
GLI3 is processed to GLI3R by the proteasome	56	2.65e-06	7.50e-05	0.39000	3.48e-02	3.89e-01	6.53e-01	4.85e-07
Plasma lipoprotein remodeling	31	2.72e-06	7.53e-05	0.52000	-4.89e-01	-1.78e-01	2.46e-06	8.63e-02
Autodegradation of the E3 ubiquitin ligase COP1	47	2.81e-06	7.64e-05	0.42400	7.83e-02	4.17e-01	3.53e-01	7.76e-07
Dectin-1 mediated noncanonical NF-kB signaling	59	3.03e-06	8.08e-05	0.37800	6.04e-02	3.73e-01	4.23e-01	7.35e-07
Degradation of DVL	54	3.25e-06	8.40e-05	0.39400	5.51e-02	3.90e-01	4.84e-01	7.20e-07
Hedgehog ligand biogenesis	61	3.26e-06	8.40e-05	0.37100	4.29e-02	3.68e-01	5.62e-01	6.56e-07
FCGR3A-mediated phagocytosis	84	3.85e-06	9.42e-05	0.31500	-1.78e-02	-3.14e-01	7.78e-01	6.52e-07
Leishmania phagocytosis	84	3.85e-06	9.42e-05	0.31500	-1.78e-02	-3.14e-01	7.78e-01	6.52e-07
Parasite infection	84	3.85e-06	9.42e-05	0.31500	-1.78e-02	-3.14e-01	7.78e-01	6.52e-07
Regulation of actin dynamics for phagocytic cup formation	85	4.41e-06	1.05e-04	0.31000	-4.82e-02	-3.06e-01	4.43e-01	1.05e-06
Cellular response to hypoxia	72	4.42e-06	1.05e-04	0.33900	-3.91e-02	3.37e-01	5.67e-01	7.54e-07
Cytosolic tRNA aminoacylation	23	4.50e-06	1.05e-04	0.58900	3.62e-01	4.64e-01	2.63e-03	1.15e-04
Gluconeogenesis	31	5.39e-06	1.23e-04	0.51800	-3.06e-01	4.18e-01	3.16e-03	5.66e-05
HSP90 chaperone cycle for steroid hormone receptors (SHR)	35	5.68e-06	1.28e-04	0.48100	-4.94e-02	4.79e-01	6.13e-01	9.51e-07
Degradation of AXIN	51	5.76e-06	1.28e-04	0.39700	2.81e-02	3.96e-01	7.28e-01	1.02e-06
Neddylation	225	8.31e-06	1.76e-04	0.18700	-2.78e-03	1.87e-01	9.43e-01	1.32e-06
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	48	8.40e-06	1.76e-04	0.40100	6.62e-02	3.96e-01	4.27e-01	2.10e-06
p53-Independent DNA Damage Response	48	8.40e-06	1.76e-04	0.40100	6.62e-02	3.96e-01	4.27e-01	2.10e-06
p53-Independent G1/S DNA damage checkpoint	48	8.40e-06	1.76e-04	0.40100	6.62e-02	3.96e-01	4.27e-01	2.10e-06
Hemostasis	578	9.43e-06	1.94e-04	0.11600	-7.63e-02	-8.71e-02	1.78e-03	3.64e-04
Cytochrome P450 - arranged by substrate type	58	1.03e-05	2.08e-04	0.35900	-2.69e-01	-2.37e-01	3.92e-04	1.81e-03
Ubiquitin-dependent degradation of Cyclin D	49	1.04e-05	2.08e-04	0.39400	4.84e-02	3.91e-01	5.58e-01	2.19e-06
Negative regulation of NOTCH4 signaling	52	1.36e-05	2.70e-04	0.37900	2.70e-02	3.78e-01	7.37e-01	2.48e-06
Stabilization of p53	51	1.40e-05	2.72e-04	0.38100	6.11e-02	3.76e-01	4.50e-01	3.43e-06
Fcgamma receptor (FCGR) dependent phagocytosis	110	1.42e-05	2.73e-04	0.26000	-3.37e-02	-2.58e-01	5.41e-01	3.08e-06
Degradation of beta-catenin by the destruction complex	81	1.69e-05	3.21e-04	0.30000	2.71e-02	2.99e-01	6.73e-01	3.25e-06
Regulation of PTEN stability and activity	66	1.88e-05	3.52e-04	0.33000	5.28e-02	3.26e-01	4.58e-01	4.60e-06
UCH proteinases	84	2.10e-05	3.89e-04	0.29200	2.62e-02	2.91e-01	6.78e-01	4.06e-06
Asymmetric localization of PCP proteins	61	2.39e-05	4.35e-04	0.33900	9.33e-02	3.26e-01	2.08e-01	1.08e-05
Downstream TCR signaling	86	2.42e-05	4.36e-04	0.28800	-2.70e-02	2.87e-01	6.65e-01	4.20e-06
Activation of NF-kappaB in B cells	62	3.56e-05	6.30e-04	0.33000	6.75e-02	3.23e-01	3.58e-01	1.07e-05
Formation of Fibrin Clot (Clotting Cascade)	35	3.58e-05	6.30e-04	0.43500	-3.10e-01	-3.06e-01	1.52e-03	1.73e-03
Phase I - Functionalization of compounds	91	3.66e-05	6.35e-04	0.27100	-2.49e-01	-1.07e-01	4.02e-05	7.70e-02
Ub-specific processing proteases	159	3.86e-05	6.63e-04	0.20800	-3.70e-02	2.05e-01	4.21e-01	8.30e-06
Biological oxidations	175	4.35e-05	7.38e-04	0.19400	-1.74e-01	-8.62e-02	7.24e-05	4.93e-02
Rho GTPase cycle	134	4.89e-05	8.20e-04	0.22000	-1.53e-01	-1.57e-01	2.20e-03	1.66e-03
Signaling by Rho GTPases	373	5.47e-05	9.07e-04	0.13300	-4.75e-02	-1.24e-01	1.16e-01	4.24e-05
Regulation of RUNX3 expression and activity	52	5.60e-05	9.18e-04	0.35400	3.74e-02	3.52e-01	6.41e-01	1.16e-05
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	128	5.79e-05	9.38e-04	0.22500	-2.42e-02	-2.24e-01	6.37e-01	1.21e-05
HSF1-dependent transactivation	30	6.82e-05	1.09e-03	0.46500	-1.09e-01	4.52e-01	3.00e-01	1.83e-05
PCP/CE pathway	89	7.58e-05	1.20e-03	0.26500	7.45e-02	2.54e-01	2.25e-01	3.38e-05
Assembly of collagen fibrils and other multimeric structures	50	7.73e-05	1.21e-03	0.36100	2.36e-01	-2.73e-01	3.96e-03	8.29e-04
Late endosomal microautophagy	30	8.41e-05	1.30e-03	0.46200	-1.82e-01	4.24e-01	8.39e-02	5.81e-05
NR1H2 and NR1H3-mediated signaling	48	9.02e-05	1.38e-03	0.35700	-3.41e-01	-1.05e-01	4.32e-05	2.08e-01
MTOR signalling	38	9.85e-05	1.49e-03	0.40400	-4.39e-02	4.01e-01	6.39e-01	1.85e-05
Signal Transduction	2249	1.09e-04	1.64e-03	0.05490	-4.40e-02	-3.29e-02	7.42e-04	1.18e-02
Miscellaneous substrates	12	1.19e-04	1.77e-03	0.69900	-5.37e-01	-4.47e-01	1.28e-03	7.37e-03
Membrane Trafficking	577	1.42e-04	2.08e-03	0.10300	-1.22e-02	1.02e-01	6.17e-01	2.75e-05
Interferon alpha/beta signaling	63	1.48e-04	2.15e-03	0.30300	-2.85e-01	-1.04e-01	9.29e-05	1.55e-01
DNA Damage/Telomere Stress Induced Senescence	41	1.50e-04	2.16e-03	0.37800	-3.73e-02	-3.76e-01	6.79e-01	3.15e-05
Cellular responses to stress	472	1.56e-04	2.22e-03	0.11200	2.30e-02	1.10e-01	3.93e-01	4.65e-05
Cell death signalling via NRAGE, NRIF and NADE	72	1.97e-04	2.79e-03	0.27800	-2.47e-01	-1.28e-01	2.95e-04	5.96e-02
Citric acid cycle (TCA cycle)	22	2.04e-04	2.86e-03	0.50800	-7.55e-03	5.08e-01	9.51e-01	3.76e-05
Collagen chain trimerization	35	2.16e-04	3.00e-03	0.40700	2.67e-01	-3.07e-01	6.31e-03	1.65e-03
Mitochondrial tRNA aminoacylation	20	2.20e-04	3.02e-03	0.52800	6.14e-02	5.24e-01	6.35e-01	4.89e-05
Asparagine N-linked glycosylation	267	2.32e-04	3.15e-03	0.14400	8.34e-02	1.17e-01	1.92e-02	1.02e-03
Mitochondrial biogenesis	86	2.53e-04	3.41e-03	0.25400	-1.43e-02	2.54e-01	8.19e-01	4.74e-05
DNA Damage Recognition in GG-NER	37	2.77e-04	3.70e-03	0.38900	-1.85e-01	3.42e-01	5.12e-02	3.16e-04
Chromosome Maintenance	98	2.82e-04	3.73e-03	0.23800	5.59e-02	-2.31e-01	3.39e-01	7.66e-05
NRAGE signals death through JNK	56	3.11e-04	4.08e-03	0.30600	-2.33e-01	-1.99e-01	2.58e-03	1.02e-02
CDT1 association with the CDC6:ORC:origin complex	56	3.27e-04	4.23e-03	0.30700	9.09e-02	2.93e-01	2.40e-01	1.48e-04
Crosslinking of collagen fibrils	10	3.29e-04	4.23e-03	0.74200	5.20e-01	-5.29e-01	4.42e-03	3.76e-03
Antigen processing-Cross presentation	92	3.36e-04	4.25e-03	0.24000	4.75e-02	2.35e-01	4.31e-01	9.75e-05
Deposition of new CENPA-containing nucleosomes at the centromere	35	3.39e-04	4.25e-03	0.39400	1.46e-01	-3.66e-01	1.35e-01	1.77e-04
Nucleosome assembly	35	3.39e-04	4.25e-03	0.39400	1.46e-01	-3.66e-01	1.35e-01	1.77e-04
Autodegradation of Cdh1 by Cdh1:APC/C	61	3.45e-04	4.28e-03	0.29400	5.77e-02	2.88e-01	4.36e-01	9.94e-05
Complement cascade	76	3.51e-04	4.33e-03	0.26100	-1.72e-01	-1.96e-01	9.44e-03	3.17e-03
CLEC7A (Dectin-1) signaling	94	3.83e-04	4.67e-03	0.23500	4.64e-02	2.31e-01	4.38e-01	1.11e-04
FCERI mediated Ca+2 mobilization	55	3.88e-04	4.70e-03	0.30900	1.06e-02	-3.09e-01	8.91e-01	7.39e-05
TCR signaling	106	3.98e-04	4.76e-03	0.22400	-3.78e-02	2.20e-01	5.02e-01	8.95e-05
Activation of ATR in response to replication stress	36	4.00e-04	4.76e-03	0.38400	1.00e-01	-3.70e-01	2.97e-01	1.21e-04
Branched-chain amino acid catabolism	21	4.14e-04	4.88e-03	0.49800	-3.23e-02	4.97e-01	7.98e-01	7.99e-05
Cellular responses to external stimuli	478	4.16e-04	4.88e-03	0.10500	2.10e-02	1.03e-01	4.33e-01	1.22e-04
Transcriptional regulation by RUNX2	115	4.41e-04	5.12e-03	0.21000	8.76e-02	1.91e-01	1.05e-01	4.12e-04
Signaling by NOTCH4	78	4.66e-04	5.37e-03	0.25700	-3.18e-02	2.55e-01	6.27e-01	9.65e-05
MyD88-independent TLR4 cascade	87	5.19e-04	5.90e-03	0.24100	-8.24e-03	2.41e-01	8.94e-01	1.01e-04
TRIF(TICAM1)-mediated TLR4 signaling	87	5.19e-04	5.90e-03	0.24100	-8.24e-03	2.41e-01	8.94e-01	1.01e-04
PINK1-PRKN Mediated Mitophagy	19	5.41e-04	6.09e-03	0.51700	-1.19e-01	5.03e-01	3.68e-01	1.46e-04
Intrinsic Pathway of Fibrin Clot Formation	22	5.61e-04	6.27e-03	0.47000	-3.80e-01	-2.77e-01	2.05e-03	2.46e-02
HIV Infection	219	5.83e-04	6.43e-03	0.15100	1.36e-02	1.50e-01	7.29e-01	1.27e-04
Assembly of active LPL and LIPC lipase complexes	19	5.85e-04	6.43e-03	0.50900	-5.06e-01	-5.90e-02	1.34e-04	6.56e-01
Synthesis of substrates in N-glycan biosythesis	60	6.44e-04	7.04e-03	0.28300	2.53e-01	1.27e-01	7.13e-04	8.91e-02
Metabolism of cofactors	18	6.65e-04	7.21e-03	0.51500	2.01e-01	4.74e-01	1.40e-01	4.91e-04
Glucose metabolism	87	7.19e-04	7.74e-03	0.23800	-6.04e-02	2.30e-01	3.31e-01	2.12e-04
COPI-mediated anterograde transport	77	7.49e-04	7.95e-03	0.25000	7.74e-03	2.50e-01	9.07e-01	1.52e-04
Fatty acid metabolism	162	7.50e-04	7.95e-03	0.17400	-2.54e-02	1.72e-01	5.77e-01	1.65e-04
Keratinization	91	7.87e-04	8.24e-03	0.23200	1.28e-01	-1.94e-01	3.45e-02	1.40e-03
Cholesterol biosynthesis	22	7.88e-04	8.24e-03	0.46800	1.04e-01	-4.57e-01	3.99e-01	2.09e-04
Chylomicron remodeling	10	8.08e-04	8.25e-03	0.68000	-5.84e-01	-3.48e-01	1.38e-03	5.64e-02
Mitophagy	26	8.10e-04	8.25e-03	0.43100	-1.51e-01	4.04e-01	1.83e-01	3.61e-04
Regulation of expression of SLITs and ROBOs	143	8.11e-04	8.25e-03	0.18000	9.63e-02	1.53e-01	4.70e-02	1.64e-03
Phenylalanine and tyrosine metabolism	11	8.12e-04	8.25e-03	0.65100	-6.17e-01	-2.07e-01	3.95e-04	2.34e-01
Regulation of Complement cascade	68	8.32e-04	8.37e-03	0.26100	-1.07e-01	-2.38e-01	1.28e-01	6.78e-04
p75 NTR receptor-mediated signalling	92	8.37e-04	8.37e-03	0.22500	-2.07e-01	-8.73e-02	6.00e-04	1.48e-01
Processing of DNA double-strand break ends	66	8.42e-04	8.37e-03	0.27000	6.09e-02	-2.63e-01	3.92e-01	2.26e-04
Peroxisomal protein import	60	8.95e-04	8.80e-03	0.28200	-1.07e-01	2.61e-01	1.52e-01	4.61e-04
Antigen processing: Ubiquitination & Proteasome degradation	289	8.97e-04	8.80e-03	0.12900	-1.85e-02	1.27e-01	5.89e-01	1.98e-04
Toll Like Receptor 9 (TLR9) Cascade	84	9.11e-04	8.88e-03	0.23700	-2.55e-02	2.36e-01	6.86e-01	1.91e-04
Toll Like Receptor 3 (TLR3) Cascade	85	1.01e-03	9.79e-03	0.23300	-1.52e-02	2.33e-01	8.08e-01	2.06e-04
The role of GTSE1 in G2/M progression after G2 checkpoint	54	1.02e-03	9.79e-03	0.29200	-1.64e-02	2.92e-01	8.35e-01	2.07e-04
Downstream signaling events of B Cell Receptor (BCR)	75	1.05e-03	1.00e-02	0.24600	5.52e-02	2.39e-01	4.08e-01	3.38e-04
APC/C:Cdc20 mediated degradation of Securin	64	1.10e-03	1.05e-02	0.26600	1.74e-02	2.66e-01	8.10e-01	2.39e-04
Formation of TC-NER Pre-Incision Complex	50	1.22e-03	1.15e-02	0.30300	-1.27e-01	2.75e-01	1.22e-01	7.71e-04
Hedgehog 'on' state	82	1.24e-03	1.16e-02	0.23100	1.27e-01	1.92e-01	4.63e-02	2.64e-03
Cell junction organization	85	1.25e-03	1.16e-02	0.22800	-2.26e-01	-3.28e-02	3.15e-04	6.01e-01
Disorders of transmembrane transporters	169	1.27e-03	1.18e-02	0.16200	4.94e-02	1.54e-01	2.68e-01	5.70e-04
Common Pathway of Fibrin Clot Formation	18	1.28e-03	1.18e-02	0.49100	-2.26e-01	-4.36e-01	9.72e-02	1.37e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs	77	1.37e-03	1.25e-02	0.23700	7.46e-02	2.25e-01	2.58e-01	6.34e-04
Transcriptional regulation by RUNX3	88	1.39e-03	1.26e-02	0.22700	-1.21e-01	1.92e-01	4.95e-02	1.91e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	1.43e-03	1.29e-02	0.65900	5.05e-02	6.57e-01	7.82e-01	3.20e-04
G alpha (i) signalling events	344	1.46e-03	1.31e-02	0.11200	-6.21e-02	-9.33e-02	4.82e-02	3.01e-03
Glycogen metabolism	25	1.56e-03	1.38e-02	0.41600	-1.12e-02	4.15e-01	9.23e-01	3.24e-04
Sulfur amino acid metabolism	25	1.56e-03	1.38e-02	0.41500	-4.15e-01	-1.26e-04	3.26e-04	9.99e-01
Plasma lipoprotein assembly	18	1.57e-03	1.38e-02	0.48400	-4.50e-01	-1.78e-01	9.46e-04	1.90e-01
Class I MHC mediated antigen processing & presentation	344	1.59e-03	1.38e-02	0.11300	-1.05e-02	1.13e-01	7.39e-01	3.40e-04
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	1.60e-03	1.38e-02	0.23900	2.23e-01	8.69e-02	9.36e-04	1.96e-01
Leishmania infection	247	1.60e-03	1.38e-02	0.13200	-2.45e-02	-1.30e-01	5.08e-01	4.56e-04
ER-Phagosome pathway	79	1.64e-03	1.41e-02	0.23200	2.39e-02	2.31e-01	7.14e-01	3.85e-04
Aflatoxin activation and detoxification	18	1.71e-03	1.46e-02	0.48000	-4.20e-01	-2.33e-01	2.06e-03	8.69e-02
Mitochondrial calcium ion transport	21	1.83e-03	1.55e-02	0.44800	-2.93e-02	4.47e-01	8.16e-01	3.87e-04
MyD88 dependent cascade initiated on endosome	80	2.11e-03	1.77e-02	0.22800	-3.60e-02	2.25e-01	5.78e-01	5.01e-04
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	39	2.11e-03	1.77e-02	0.32300	-3.15e-01	-7.08e-02	6.69e-04	4.45e-01
ER to Golgi Anterograde Transport	126	2.17e-03	1.80e-02	0.18100	-2.24e-02	1.80e-01	6.65e-01	4.89e-04
Metabolism of steroids	133	2.17e-03	1.80e-02	0.17400	-8.70e-02	-1.50e-01	8.35e-02	2.76e-03
FCGR activation	39	2.19e-03	1.80e-02	0.32400	-9.46e-03	-3.23e-01	9.19e-01	4.75e-04
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	74	2.20e-03	1.80e-02	0.23800	-1.33e-01	1.98e-01	4.73e-02	3.31e-03
Elastic fibre formation	38	2.23e-03	1.81e-02	0.33200	2.27e-01	-2.42e-01	1.53e-02	9.72e-03
Metabolism of amino acids and derivatives	333	2.25e-03	1.82e-02	0.11200	-2.51e-02	1.09e-01	4.32e-01	6.18e-04
Endosomal/Vacuolar pathway	10	2.42e-03	1.95e-02	0.62700	-5.84e-01	-2.30e-01	1.39e-03	2.08e-01
Scavenging of heme from plasma	38	2.44e-03	1.96e-02	0.32700	5.37e-02	-3.22e-01	5.67e-01	5.91e-04
MyD88 cascade initiated on plasma membrane	76	2.62e-03	2.05e-02	0.23000	-4.60e-02	2.25e-01	4.88e-01	6.81e-04
Toll Like Receptor 10 (TLR10) Cascade	76	2.62e-03	2.05e-02	0.23000	-4.60e-02	2.25e-01	4.88e-01	6.81e-04
Toll Like Receptor 5 (TLR5) Cascade	76	2.62e-03	2.05e-02	0.23000	-4.60e-02	2.25e-01	4.88e-01	6.81e-04
Plasma lipoprotein assembly, remodeling, and clearance	68	2.62e-03	2.05e-02	0.24100	-2.40e-01	-2.36e-02	6.25e-04	7.36e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	79	2.65e-03	2.06e-02	0.22500	-3.00e-02	2.23e-01	6.45e-01	6.12e-04
Activation of the pre-replicative complex	32	2.66e-03	2.06e-02	0.35600	1.59e-01	-3.18e-01	1.21e-01	1.82e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	2.73e-03	2.11e-02	0.50600	-4.55e-01	-2.22e-01	2.27e-03	1.37e-01
rRNA processing in the mitochondrion	21	2.79e-03	2.14e-02	0.43800	-2.20e-01	3.79e-01	8.13e-02	2.67e-03
IRE1alpha activates chaperones	50	2.93e-03	2.23e-02	0.27700	7.39e-02	2.67e-01	3.66e-01	1.09e-03
Toll Like Receptor 7/8 (TLR7/8) Cascade	81	3.03e-03	2.30e-02	0.22000	-4.17e-02	2.16e-01	5.17e-01	7.76e-04
Energy dependent regulation of mTOR by LKB1-AMPK	28	3.17e-03	2.39e-02	0.36800	8.43e-02	3.58e-01	4.40e-01	1.04e-03
Host Interactions of HIV factors	123	3.33e-03	2.50e-02	0.17500	3.35e-02	1.72e-01	5.21e-01	9.81e-04
FCGR3A-mediated IL10 synthesis	64	3.34e-03	2.50e-02	0.24200	-6.08e-02	-2.35e-01	4.00e-01	1.18e-03
Mitochondrial iron-sulfur cluster biogenesis	11	3.51e-03	2.61e-02	0.57800	3.03e-01	4.92e-01	8.17e-02	4.74e-03
Presynaptic phase of homologous DNA pairing and strand exchange	38	3.62e-03	2.68e-02	0.31700	8.93e-02	-3.04e-01	3.41e-01	1.19e-03
p130Cas linkage to MAPK signaling for integrins	15	3.64e-03	2.68e-02	0.49400	-4.53e-01	-1.97e-01	2.37e-03	1.86e-01
XBP1(S) activates chaperone genes	48	3.66e-03	2.68e-02	0.27700	7.12e-02	2.68e-01	3.93e-01	1.31e-03
Aggrephagy	20	3.76e-03	2.74e-02	0.43200	-2.67e-02	4.31e-01	8.36e-01	8.38e-04
Hedgehog 'off' state	95	3.81e-03	2.76e-02	0.19800	-3.51e-03	1.98e-01	9.53e-01	8.46e-04
COPI-independent Golgi-to-ER retrograde traffic	33	3.98e-03	2.87e-02	0.33400	2.56e-03	3.34e-01	9.80e-01	8.92e-04
Cellular response to heat stress	92	4.10e-03	2.94e-02	0.19900	2.56e-02	1.98e-01	6.72e-01	1.06e-03
SCF(Skp2)-mediated degradation of p27/p21	58	4.18e-03	2.96e-02	0.25000	4.80e-02	2.45e-01	5.27e-01	1.24e-03
p53-Dependent G1 DNA Damage Response	60	4.23e-03	2.96e-02	0.24600	3.77e-02	2.43e-01	6.14e-01	1.15e-03
p53-Dependent G1/S DNA damage checkpoint	60	4.23e-03	2.96e-02	0.24600	3.77e-02	2.43e-01	6.14e-01	1.15e-03
Cristae formation	27	4.26e-03	2.96e-02	0.36400	1.36e-01	3.37e-01	2.20e-01	2.44e-03
Role of phospholipids in phagocytosis	52	4.27e-03	2.96e-02	0.26500	1.17e-02	-2.65e-01	8.84e-01	9.56e-04
Recycling of bile acids and salts	15	4.28e-03	2.96e-02	0.48600	-2.94e-01	-3.87e-01	4.88e-02	9.54e-03
DARPP-32 events	23	4.29e-03	2.96e-02	0.40300	-2.91e-01	2.79e-01	1.57e-02	2.04e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	33	4.30e-03	2.96e-02	0.32900	1.12e-01	3.09e-01	2.65e-01	2.11e-03
Chylomicron assembly	10	4.33e-03	2.97e-02	0.59500	-5.32e-01	-2.67e-01	3.56e-03	1.44e-01
CDK-mediated phosphorylation and removal of Cdc6	69	4.34e-03	2.97e-02	0.22800	6.31e-02	2.19e-01	3.65e-01	1.67e-03
Defects in vitamin and cofactor metabolism	22	4.40e-03	2.99e-02	0.41100	-3.53e-01	2.09e-01	4.11e-03	8.91e-02
Degradation of the extracellular matrix	101	4.51e-03	3.05e-02	0.19100	5.54e-02	-1.83e-01	3.36e-01	1.53e-03
Resolution of Sister Chromatid Cohesion	103	4.52e-03	3.05e-02	0.18900	6.91e-02	-1.76e-01	2.26e-01	2.01e-03
Eicosanoids	12	4.58e-03	3.07e-02	0.53900	-3.51e-01	-4.10e-01	3.55e-02	1.40e-02
Formation of the beta-catenin:TCF transactivating complex	41	4.60e-03	3.07e-02	0.29400	-2.82e-01	-8.10e-02	1.76e-03	3.69e-01
Death Receptor Signalling	132	4.73e-03	3.14e-02	0.16400	-1.62e-01	-2.45e-02	1.28e-03	6.28e-01
Peroxisomal lipid metabolism	27	5.02e-03	3.32e-02	0.36300	-4.13e-02	3.61e-01	7.10e-01	1.19e-03
Cell Cycle	607	5.12e-03	3.37e-02	0.07800	2.12e-02	-7.51e-02	3.75e-01	1.64e-03
Regulation of IFNA signaling	24	5.20e-03	3.41e-02	0.37700	-2.72e-01	-2.61e-01	2.13e-02	2.68e-02
Keratan sulfate degradation	12	5.24e-03	3.42e-02	0.54100	5.40e-01	-2.26e-02	1.19e-03	8.92e-01
mTORC1-mediated signalling	22	5.29e-03	3.44e-02	0.40000	-6.30e-02	3.95e-01	6.09e-01	1.33e-03
Role of LAT2/NTAL/LAB on calcium mobilization	40	5.35e-03	3.44e-02	0.29800	8.08e-02	-2.87e-01	3.77e-01	1.71e-03
G1/S DNA Damage Checkpoints	61	5.36e-03	3.44e-02	0.23800	3.63e-02	2.36e-01	6.24e-01	1.47e-03
Meiosis	67	5.36e-03	3.44e-02	0.22900	9.99e-03	-2.28e-01	8.88e-01	1.22e-03
PTEN Regulation	145	5.40e-03	3.44e-02	0.15500	8.37e-03	1.55e-01	8.62e-01	1.28e-03
Vesicle-mediated transport	638	5.56e-03	3.53e-02	0.07520	-6.44e-03	7.49e-02	7.82e-01	1.29e-03
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	56	5.66e-03	3.58e-02	0.25000	4.95e-02	-2.45e-01	5.22e-01	1.53e-03
Influenza Infection	127	5.79e-03	3.64e-02	0.16300	1.54e-01	5.49e-02	2.75e-03	2.85e-01
EPHB-mediated forward signaling	33	5.89e-03	3.69e-02	0.32200	-5.02e-04	-3.22e-01	9.96e-01	1.36e-03
Role of second messengers in netrin-1 signaling	10	5.97e-03	3.72e-02	0.59300	3.75e-01	-4.59e-01	4.01e-02	1.19e-02
Extra-nuclear estrogen signaling	71	6.00e-03	3.72e-02	0.22200	1.90e-01	-1.16e-01	5.77e-03	8.99e-02
Cell-cell junction organization	60	6.06e-03	3.72e-02	0.23600	-2.22e-01	-8.18e-02	2.99e-03	2.73e-01
Keratan sulfate/keratin metabolism	31	6.07e-03	3.72e-02	0.33400	3.25e-01	-7.66e-02	1.75e-03	4.61e-01
Factors involved in megakaryocyte development and platelet production	124	6.07e-03	3.72e-02	0.16600	-1.66e-01	-1.02e-02	1.46e-03	8.45e-01
Regulation of lipid metabolism by PPARalpha	116	6.18e-03	3.76e-02	0.17200	-1.69e-01	3.14e-02	1.63e-03	5.59e-01
MAPK6/MAPK4 signaling	84	6.18e-03	3.76e-02	0.20200	-2.06e-02	2.01e-01	7.45e-01	1.47e-03
Pyruvate metabolism	28	6.33e-03	3.83e-02	0.34700	5.63e-03	3.47e-01	9.59e-01	1.48e-03
Platelet Aggregation (Plug Formation)	37	6.37e-03	3.84e-02	0.30200	-3.01e-01	-1.41e-02	1.52e-03	8.82e-01
TRAF6 mediated IRF7 activation	26	6.55e-03	3.94e-02	0.35500	-3.20e-01	-1.55e-01	4.79e-03	1.72e-01
Carnitine metabolism	11	6.79e-03	4.06e-02	0.55600	-2.22e-01	5.10e-01	2.02e-01	3.43e-03
G2/M DNA damage checkpoint	64	6.84e-03	4.08e-02	0.22800	8.82e-03	-2.28e-01	9.03e-01	1.59e-03
Keratan sulfate biosynthesis	26	6.92e-03	4.11e-02	0.36100	3.40e-01	-1.20e-01	2.70e-03	2.90e-01
MAP kinase activation	60	7.28e-03	4.30e-02	0.23600	-5.37e-02	2.29e-01	4.72e-01	2.11e-03
TNFR2 non-canonical NF-kB pathway	94	7.59e-03	4.46e-02	0.18600	2.04e-02	1.85e-01	7.33e-01	1.97e-03
Iron uptake and transport	54	7.60e-03	4.46e-02	0.24200	1.44e-01	1.95e-01	6.64e-02	1.34e-02
Glyoxylate metabolism and glycine degradation	29	7.67e-03	4.48e-02	0.34000	-2.45e-01	2.35e-01	2.22e-02	2.86e-02
Glycosaminoglycan metabolism	117	7.78e-03	4.52e-02	0.16900	1.25e-01	-1.14e-01	1.97e-02	3.29e-02
Attenuation phase	21	7.89e-03	4.57e-02	0.39400	-5.11e-02	3.90e-01	6.85e-01	1.96e-03
Endosomal Sorting Complex Required For Transport (ESCRT)	29	8.02e-03	4.60e-02	0.33800	-2.08e-01	2.67e-01	5.30e-02	1.29e-02
N-Glycan antennae elongation	14	8.03e-03	4.60e-02	0.48400	1.85e-01	-4.47e-01	2.30e-01	3.75e-03
Biotin transport and metabolism	11	8.04e-03	4.60e-02	0.54800	-4.53e-01	3.09e-01	9.35e-03	7.59e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF)	53	8.24e-03	4.70e-02	0.24200	-1.64e-01	-1.78e-01	3.86e-02	2.48e-02
Regulation of RAS by GAPs	65	8.33e-03	4.73e-02	0.22100	4.73e-02	2.15e-01	5.09e-01	2.68e-03
Chromatin modifying enzymes	208	8.72e-03	4.91e-02	0.12400	-1.24e-01	9.21e-03	2.09e-03	8.19e-01
Chromatin organization	208	8.72e-03	4.91e-02	0.12400	-1.24e-01	9.21e-03	2.09e-03	8.19e-01
Cyclin A:Cdk2-associated events at S phase entry	83	8.75e-03	4.91e-02	0.19400	5.31e-02	1.87e-01	4.04e-01	3.31e-03
FCERI mediated MAPK activation	56	8.79e-03	4.92e-02	0.24000	1.02e-01	-2.18e-01	1.88e-01	4.83e-03
Josephin domain DUBs	10	8.97e-03	5.00e-02	0.55700	1.26e-01	5.42e-01	4.90e-01	2.97e-03
TP53 Regulates Metabolic Genes	83	9.01e-03	5.00e-02	0.19500	2.86e-03	1.95e-01	9.64e-01	2.17e-03
Meiotic recombination	37	9.29e-03	5.13e-02	0.29300	7.78e-02	-2.82e-01	4.13e-01	2.98e-03
Cytosolic sensors of pathogen-associated DNA	55	9.43e-03	5.19e-02	0.23800	-1.17e-02	2.38e-01	8.81e-01	2.26e-03
Mitotic Prometaphase	182	9.55e-03	5.24e-02	0.13200	2.78e-02	-1.29e-01	5.18e-01	2.72e-03
ATF6 (ATF6-alpha) activates chaperone genes	10	9.59e-03	5.24e-02	0.55700	-2.88e-03	5.57e-01	9.87e-01	2.31e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	70	9.91e-03	5.39e-02	0.21000	-7.25e-04	2.10e-01	9.92e-01	2.39e-03
RHO GTPase Effectors	249	1.01e-02	5.48e-02	0.11200	3.10e-03	-1.12e-01	9.33e-01	2.43e-03
Activation of the phototransduction cascade	10	1.02e-02	5.51e-02	0.55400	3.45e-02	-5.53e-01	8.50e-01	2.47e-03
Reproduction	86	1.04e-02	5.59e-02	0.18800	-9.24e-03	-1.88e-01	8.82e-01	2.60e-03
HSF1 activation	24	1.04e-02	5.59e-02	0.35900	-9.08e-02	3.47e-01	4.41e-01	3.26e-03
Nucleotide Excision Repair	106	1.06e-02	5.68e-02	0.17200	-1.10e-01	1.32e-01	5.11e-02	1.86e-02
Glycogen synthesis	14	1.09e-02	5.79e-02	0.46200	6.01e-02	4.58e-01	6.97e-01	2.99e-03
Cyclin E associated events during G1/S transition	81	1.09e-02	5.79e-02	0.19200	4.66e-02	1.86e-01	4.68e-01	3.80e-03
Protein ubiquitination	65	1.10e-02	5.79e-02	0.21600	-2.16e-01	2.87e-03	2.66e-03	9.68e-01
PPARA activates gene expression	114	1.12e-02	5.88e-02	0.16300	-1.60e-01	3.12e-02	3.10e-03	5.65e-01
Metabolism of lipids	687	1.12e-02	5.89e-02	0.06830	-5.32e-02	4.28e-02	1.79e-02	5.69e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	1.13e-02	5.90e-02	0.47300	3.19e-01	3.49e-01	4.63e-02	2.95e-02
Assembly of the pre-replicative complex	65	1.13e-02	5.90e-02	0.21200	9.56e-02	1.89e-01	1.83e-01	8.28e-03
MHC class II antigen presentation	94	1.14e-02	5.93e-02	0.17900	-2.71e-02	1.77e-01	6.50e-01	3.00e-03
GPCR ligand binding	381	1.17e-02	6.03e-02	0.08820	-3.56e-02	-8.07e-02	2.34e-01	6.94e-03
tRNA processing in the mitochondrion	18	1.19e-02	6.14e-02	0.41100	-3.24e-01	2.52e-01	1.73e-02	6.38e-02
Post-translational modification: synthesis of GPI-anchored proteins	81	1.20e-02	6.14e-02	0.19200	3.58e-02	-1.89e-01	5.78e-01	3.31e-03
CD28 dependent Vav1 pathway	12	1.20e-02	6.15e-02	0.49100	-1.84e-01	-4.55e-01	2.69e-01	6.39e-03
Class I peroxisomal membrane protein import	18	1.21e-02	6.15e-02	0.41000	-2.74e-01	3.06e-01	4.42e-02	2.48e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	1.22e-02	6.19e-02	0.20500	8.20e-02	-1.87e-01	2.29e-01	5.99e-03
Ovarian tumor domain proteases	35	1.25e-02	6.34e-02	0.29200	-1.01e-01	2.74e-01	3.02e-01	5.07e-03
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	16	1.30e-02	6.53e-02	0.42000	-3.69e-01	-2.01e-01	1.06e-02	1.63e-01
Diseases of hemostasis	16	1.30e-02	6.53e-02	0.42000	-3.69e-01	-2.01e-01	1.06e-02	1.63e-01
G alpha (12/13) signalling events	76	1.30e-02	6.53e-02	0.19300	-8.90e-02	-1.71e-01	1.80e-01	9.80e-03
Signaling by NOTCH	183	1.34e-02	6.67e-02	0.12800	-1.01e-01	7.79e-02	1.83e-02	6.94e-02
mRNA Splicing - Major Pathway	168	1.34e-02	6.67e-02	0.13000	-1.24e-01	-4.06e-02	5.69e-03	3.64e-01
Generation of second messenger molecules	27	1.39e-02	6.86e-02	0.32600	-3.25e-01	2.51e-02	3.48e-03	8.21e-01
Processing of SMDT1	14	1.39e-02	6.88e-02	0.45000	3.63e-02	4.49e-01	8.14e-01	3.66e-03
Signaling by ROBO receptors	188	1.40e-02	6.89e-02	0.12300	2.79e-02	1.20e-01	5.10e-01	4.72e-03
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	98	1.40e-02	6.89e-02	0.17200	3.13e-02	-1.69e-01	5.92e-01	3.91e-03
Activation of gene expression by SREBF (SREBP)	41	1.44e-02	7.02e-02	0.25900	-1.84e-01	-1.82e-01	4.16e-02	4.33e-02
Downregulation of TGF-beta receptor signaling	25	1.45e-02	7.06e-02	0.33100	2.43e-01	2.26e-01	3.58e-02	5.09e-02
mRNA Splicing	176	1.45e-02	7.06e-02	0.12600	-1.18e-01	-4.29e-02	6.75e-03	3.27e-01
Homologous DNA Pairing and Strand Exchange	41	1.46e-02	7.06e-02	0.26500	9.14e-02	-2.49e-01	3.11e-01	5.88e-03
Metabolism of fat-soluble vitamins	43	1.46e-02	7.06e-02	0.25300	-1.49e-01	-2.04e-01	9.03e-02	2.08e-02
KSRP (KHSRP) binds and destabilizes mRNA	17	1.49e-02	7.14e-02	0.41000	1.60e-01	-3.78e-01	2.53e-01	6.98e-03
Classical antibody-mediated complement activation	32	1.49e-02	7.14e-02	0.29900	8.78e-02	-2.85e-01	3.90e-01	5.20e-03
Developmental Biology	863	1.55e-02	7.38e-02	0.05740	-4.64e-02	-3.38e-02	2.14e-02	9.35e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter	24	1.56e-02	7.41e-02	0.34500	-2.12e-01	2.72e-01	7.21e-02	2.11e-02
Transcriptional activation of mitochondrial biogenesis	52	1.56e-02	7.41e-02	0.23400	-8.70e-02	2.17e-01	2.78e-01	6.88e-03
Beta-oxidation of very long chain fatty acids	10	1.58e-02	7.48e-02	0.52400	6.06e-02	5.20e-01	7.40e-01	4.38e-03
Viral mRNA Translation	65	1.62e-02	7.63e-02	0.20500	2.04e-01	2.33e-02	4.48e-03	7.46e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26	1.64e-02	7.72e-02	0.32800	1.32e-01	-3.00e-01	2.43e-01	8.03e-03
Visual phototransduction	92	1.65e-02	7.74e-02	0.17300	1.17e-02	-1.73e-01	8.46e-01	4.20e-03
Telomere C-strand (Lagging Strand) Synthesis	33	1.67e-02	7.77e-02	0.28900	3.67e-02	-2.86e-01	7.15e-01	4.40e-03
RHO GTPases Activate Formins	118	1.71e-02	7.93e-02	0.15300	4.68e-02	-1.46e-01	3.80e-01	6.16e-03
Cell Cycle Checkpoints	251	1.71e-02	7.93e-02	0.10600	4.56e-02	-9.56e-02	2.14e-01	9.23e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	70	1.72e-02	7.93e-02	0.19600	1.94e-01	2.78e-02	4.95e-03	6.88e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	117	1.74e-02	8.03e-02	0.15100	-6.20e-02	-1.37e-01	2.47e-01	1.03e-02
Peptide ligand-binding receptors	157	1.77e-02	8.11e-02	0.13000	-1.12e-01	-6.64e-02	1.59e-02	1.52e-01
SRP-dependent cotranslational protein targeting to membrane	88	1.78e-02	8.13e-02	0.17500	1.75e-01	-1.02e-02	4.54e-03	8.69e-01
Constitutive Signaling by Aberrant PI3K in Cancer	71	1.78e-02	8.13e-02	0.19600	5.70e-02	-1.88e-01	4.06e-01	6.20e-03
Retinoid metabolism and transport	39	1.79e-02	8.14e-02	0.25900	-1.86e-01	-1.80e-01	4.46e-02	5.20e-02
Signaling by NOTCH1	69	1.80e-02	8.17e-02	0.19800	-1.95e-01	3.52e-02	5.08e-03	6.13e-01
Homology Directed Repair	104	1.83e-02	8.26e-02	0.16100	2.57e-02	-1.59e-01	6.51e-01	5.03e-03
Chaperone Mediated Autophagy	18	1.84e-02	8.29e-02	0.39000	-1.90e-01	3.40e-01	1.63e-01	1.25e-02
Transcriptional regulation by RUNX1	185	1.85e-02	8.30e-02	0.12200	-4.42e-02	1.13e-01	3.01e-01	7.86e-03
Cleavage of the damaged pyrimidine	25	1.89e-02	8.37e-02	0.33000	1.73e-01	-2.81e-01	1.35e-01	1.50e-02
Depyrimidination	25	1.89e-02	8.37e-02	0.33000	1.73e-01	-2.81e-01	1.35e-01	1.50e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	25	1.89e-02	8.37e-02	0.33000	1.73e-01	-2.81e-01	1.35e-01	1.50e-02
Mitotic Spindle Checkpoint	107	1.89e-02	8.37e-02	0.15900	6.16e-02	-1.47e-01	2.71e-01	8.67e-03
Base-Excision Repair, AP Site Formation	27	1.96e-02	8.59e-02	0.31600	1.69e-01	-2.67e-01	1.29e-01	1.63e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21	1.96e-02	8.59e-02	0.34800	-2.45e-01	-2.48e-01	5.19e-02	4.95e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	91	1.96e-02	8.59e-02	0.17200	7.21e-02	-1.56e-01	2.35e-01	1.01e-02
Amplification of signal from the kinetochores	91	1.96e-02	8.59e-02	0.17200	7.21e-02	-1.56e-01	2.35e-01	1.01e-02
Interleukin-17 signaling	68	1.97e-02	8.59e-02	0.19800	-3.79e-02	1.94e-01	5.89e-01	5.69e-03
Class A/1 (Rhodopsin-like receptors)	271	1.97e-02	8.59e-02	0.09760	-6.30e-02	-7.46e-02	7.47e-02	3.49e-02
Transport of organic anions	12	1.99e-02	8.64e-02	0.46000	-2.60e-01	-3.80e-01	1.19e-01	2.28e-02
Regulation of innate immune responses to cytosolic DNA	13	2.03e-02	8.76e-02	0.44400	1.03e-01	4.32e-01	5.19e-01	7.01e-03
Major pathway of rRNA processing in the nucleolus and cytosol	156	2.03e-02	8.76e-02	0.13000	1.28e-01	-2.10e-02	5.66e-03	6.51e-01
Prolactin receptor signaling	12	2.04e-02	8.79e-02	0.47200	-3.00e-01	3.64e-01	7.21e-02	2.90e-02
RHO GTPases Activate WASPs and WAVEs	35	2.08e-02	8.94e-02	0.27100	-3.65e-02	-2.68e-01	7.09e-01	6.04e-03
RNA Polymerase III Abortive And Retractive Initiation	37	2.10e-02	8.94e-02	0.26700	-2.49e-01	9.59e-02	8.82e-03	3.13e-01
RNA Polymerase III Transcription	37	2.10e-02	8.94e-02	0.26700	-2.49e-01	9.59e-02	8.82e-03	3.13e-01
rRNA processing in the nucleus and cytosol	165	2.13e-02	9.06e-02	0.12600	1.25e-01	-1.65e-02	5.79e-03	7.15e-01
Apoptosis	161	2.14e-02	9.07e-02	0.12700	5.47e-03	1.26e-01	9.05e-01	5.68e-03
Selenoamino acid metabolism	90	2.17e-02	9.12e-02	0.16800	1.66e-01	2.71e-02	6.55e-03	6.57e-01
Zinc influx into cells by the SLC39 gene family	10	2.17e-02	9.12e-02	0.51100	4.56e-01	-2.32e-01	1.26e-02	2.04e-01
HDR through Single Strand Annealing (SSA)	37	2.17e-02	9.12e-02	0.26500	6.69e-02	-2.56e-01	4.81e-01	7.01e-03
EML4 and NUDC in mitotic spindle formation	95	2.18e-02	9.12e-02	0.16600	7.79e-02	-1.47e-01	1.90e-01	1.34e-02
Orc1 removal from chromatin	68	2.24e-02	9.35e-02	0.19100	7.63e-02	1.75e-01	2.77e-01	1.24e-02
Post-translational protein phosphorylation	103	2.24e-02	9.35e-02	0.15600	-5.76e-02	-1.45e-01	3.13e-01	1.13e-02
Glycogen storage diseases	14	2.25e-02	9.35e-02	0.42700	-8.23e-02	4.19e-01	5.94e-01	6.58e-03
Cell-extracellular matrix interactions	16	2.27e-02	9.39e-02	0.39900	-3.96e-01	4.42e-02	6.09e-03	7.60e-01
Glycolysis	68	2.30e-02	9.52e-02	0.19300	-2.83e-02	1.91e-01	6.87e-01	6.39e-03
Programmed Cell Death	171	2.32e-02	9.54e-02	0.12100	1.11e-02	1.21e-01	8.02e-01	6.45e-03
trans-Golgi Network Vesicle Budding	70	2.34e-02	9.61e-02	0.19000	-8.48e-03	1.89e-01	9.02e-01	6.14e-03
Pexophagy	10	2.36e-02	9.67e-02	0.50600	-2.62e-01	4.33e-01	1.51e-01	1.77e-02
Signaling by Hedgehog	131	2.39e-02	9.74e-02	0.13700	3.73e-02	1.32e-01	4.61e-01	9.06e-03
G alpha (q) signalling events	195	2.43e-02	9.87e-02	0.11300	-2.82e-02	-1.09e-01	4.98e-01	8.78e-03
Transferrin endocytosis and recycling	29	2.43e-02	9.87e-02	0.28800	2.23e-01	1.83e-01	3.75e-02	8.88e-02
G alpha (s) signalling events	209	2.45e-02	9.90e-02	0.10800	-6.97e-02	-8.23e-02	8.27e-02	4.05e-02
CD22 mediated BCR regulation	31	2.45e-02	9.90e-02	0.28400	5.42e-02	-2.79e-01	6.02e-01	7.21e-03
Activated NOTCH1 Transmits Signal to the Nucleus	30	2.46e-02	9.92e-02	0.29000	-2.61e-01	1.28e-01	1.35e-02	2.25e-01
Activation of HOX genes during differentiation	65	2.52e-02	1.01e-01	0.19200	-1.67e-01	-9.46e-02	1.97e-02	1.87e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	65	2.52e-02	1.01e-01	0.19200	-1.67e-01	-9.46e-02	1.97e-02	1.87e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	69	2.59e-02	1.04e-01	0.18800	1.85e-02	1.87e-01	7.90e-01	7.35e-03
Cell Cycle, Mitotic	484	2.61e-02	1.04e-01	0.07270	3.32e-02	-6.47e-02	2.12e-01	1.51e-02
Cell-Cell communication	117	2.65e-02	1.05e-01	0.14400	-1.44e-01	-3.14e-03	7.11e-03	9.53e-01
Intra-Golgi traffic	42	2.69e-02	1.07e-01	0.23800	2.28e-01	6.79e-02	1.06e-02	4.46e-01
Cyclin A/B1/B2 associated events during G2/M transition	23	2.74e-02	1.08e-01	0.32600	8.76e-02	-3.14e-01	4.67e-01	9.25e-03
N-glycan antennae elongation in the medial/trans-Golgi	23	2.75e-02	1.08e-01	0.32700	1.58e-01	-2.86e-01	1.90e-01	1.75e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	13	2.87e-02	1.13e-01	0.42500	4.22e-01	5.10e-02	8.40e-03	7.50e-01
Inositol phosphate metabolism	47	2.91e-02	1.14e-01	0.22400	2.07e-02	2.23e-01	8.06e-01	8.28e-03
RNA Polymerase III Transcription Termination	19	2.92e-02	1.14e-01	0.35700	-2.89e-01	2.10e-01	2.91e-02	1.14e-01
Pausing and recovery of Tat-mediated HIV elongation	32	2.93e-02	1.14e-01	0.27500	-2.33e-01	1.47e-01	2.28e-02	1.51e-01
Tat-mediated HIV elongation arrest and recovery	32	2.93e-02	1.14e-01	0.27500	-2.33e-01	1.47e-01	2.28e-02	1.51e-01
Signaling by Retinoic Acid	38	2.94e-02	1.14e-01	0.24700	7.78e-02	2.34e-01	4.06e-01	1.25e-02
Tight junction interactions	28	2.97e-02	1.15e-01	0.28700	-2.76e-01	-7.87e-02	1.14e-02	4.71e-01
Striated Muscle Contraction	34	2.98e-02	1.15e-01	0.26600	-1.48e-01	2.21e-01	1.36e-01	2.55e-02
Extension of Telomeres	50	3.02e-02	1.16e-01	0.21700	1.79e-02	-2.16e-01	8.27e-01	8.23e-03
Regulation of HSF1-mediated heat shock response	76	3.09e-02	1.18e-01	0.17300	7.17e-02	1.58e-01	2.80e-01	1.76e-02
TGF-beta receptor signaling activates SMADs	30	3.12e-02	1.19e-01	0.27400	1.60e-01	2.22e-01	1.29e-01	3.52e-02
FCERI mediated NF-kB activation	99	3.14e-02	1.20e-01	0.15200	5.70e-02	1.40e-01	3.27e-01	1.58e-02
PKA activation in glucagon signalling	16	3.17e-02	1.21e-01	0.38200	-3.68e-01	1.02e-01	1.08e-02	4.79e-01
Interleukin-6 family signaling	24	3.19e-02	1.21e-01	0.31400	-2.39e-01	2.03e-01	4.23e-02	8.49e-02
Dectin-2 family	19	3.24e-02	1.23e-01	0.35100	1.31e-01	-3.25e-01	3.24e-01	1.41e-02
RMTs methylate histone arginines	36	3.26e-02	1.23e-01	0.25600	-1.83e-01	1.79e-01	5.75e-02	6.38e-02
Resolution of D-Loop Structures	33	3.39e-02	1.28e-01	0.26500	1.28e-01	-2.32e-01	2.04e-01	2.11e-02
Anti-inflammatory response favouring Leishmania parasite infection	168	3.43e-02	1.28e-01	0.11500	-4.42e-02	-1.06e-01	3.23e-01	1.77e-02
Leishmania parasite growth and survival	168	3.43e-02	1.28e-01	0.11500	-4.42e-02	-1.06e-01	3.23e-01	1.77e-02
Glycosphingolipid metabolism	40	3.43e-02	1.28e-01	0.23600	5.69e-02	2.29e-01	5.34e-01	1.24e-02
Condensation of Prophase Chromosomes	24	3.45e-02	1.28e-01	0.30400	-5.18e-02	-3.00e-01	6.60e-01	1.10e-02
Calnexin/calreticulin cycle	24	3.45e-02	1.28e-01	0.30200	1.46e-01	2.64e-01	2.15e-01	2.49e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	86	3.49e-02	1.29e-01	0.16200	-9.87e-03	1.62e-01	8.74e-01	9.63e-03
Toll Like Receptor 2 (TLR2) Cascade	86	3.49e-02	1.29e-01	0.16200	-9.87e-03	1.62e-01	8.74e-01	9.63e-03
Toll Like Receptor TLR1:TLR2 Cascade	86	3.49e-02	1.29e-01	0.16200	-9.87e-03	1.62e-01	8.74e-01	9.63e-03
Toll Like Receptor TLR6:TLR2 Cascade	86	3.49e-02	1.29e-01	0.16200	-9.87e-03	1.62e-01	8.74e-01	9.63e-03
RA biosynthesis pathway	18	3.52e-02	1.29e-01	0.34700	2.89e-01	1.93e-01	3.37e-02	1.57e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	77	3.55e-02	1.30e-01	0.16900	1.66e-01	3.33e-02	1.18e-02	6.13e-01
HDR through Homologous Recombination (HRR)	63	3.59e-02	1.31e-01	0.19000	6.07e-02	-1.80e-01	4.05e-01	1.37e-02
RNA Polymerase III Chain Elongation	14	3.59e-02	1.31e-01	0.40100	-9.15e-02	3.90e-01	5.53e-01	1.15e-02
Synthesis of PIPs at the late endosome membrane	11	3.60e-02	1.31e-01	0.44300	3.56e-01	2.63e-01	4.07e-02	1.31e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	70	3.60e-02	1.31e-01	0.17700	2.62e-02	1.75e-01	7.05e-01	1.11e-02
Polymerase switching on the C-strand of the telomere	25	3.75e-02	1.35e-01	0.29700	2.31e-02	-2.96e-01	8.42e-01	1.05e-02
Defensins	19	3.77e-02	1.36e-01	0.34000	-3.37e-01	4.56e-02	1.09e-02	7.31e-01
Cap-dependent Translation Initiation	92	3.83e-02	1.37e-01	0.15200	1.16e-01	9.79e-02	5.41e-02	1.05e-01
Eukaryotic Translation Initiation	92	3.83e-02	1.37e-01	0.15200	1.16e-01	9.79e-02	5.41e-02	1.05e-01
Binding and Uptake of Ligands by Scavenger Receptors	63	3.83e-02	1.37e-01	0.18800	5.62e-02	-1.79e-01	4.41e-01	1.40e-02
Peptide chain elongation	65	3.83e-02	1.37e-01	0.18300	1.83e-01	8.97e-03	1.09e-02	9.01e-01
Eukaryotic Translation Elongation	69	3.84e-02	1.37e-01	0.17700	1.72e-01	4.05e-02	1.36e-02	5.61e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	23	3.89e-02	1.38e-01	0.30700	8.34e-03	3.07e-01	9.45e-01	1.09e-02
FOXO-mediated transcription of cell death genes	14	3.92e-02	1.39e-01	0.39900	-2.90e-01	2.73e-01	6.01e-02	7.67e-02
VLDLR internalisation and degradation	12	3.96e-02	1.40e-01	0.42600	-8.23e-02	4.18e-01	6.22e-01	1.22e-02
HIV elongation arrest and recovery	34	3.98e-02	1.40e-01	0.25500	-2.04e-01	1.53e-01	3.96e-02	1.22e-01
Pausing and recovery of HIV elongation	34	3.98e-02	1.40e-01	0.25500	-2.04e-01	1.53e-01	3.96e-02	1.22e-01
Synthesis of IP2, IP, and Ins in the cytosol	14	4.05e-02	1.42e-01	0.38600	3.25e-01	2.08e-01	3.54e-02	1.78e-01
DNA strand elongation	31	4.12e-02	1.44e-01	0.26100	-1.99e-02	-2.61e-01	8.48e-01	1.20e-02
LDL clearance	18	4.13e-02	1.44e-01	0.34000	3.12e-01	1.35e-01	2.19e-02	3.22e-01
Amino acids regulate mTORC1	50	4.14e-02	1.44e-01	0.20400	7.79e-02	1.89e-01	3.41e-01	2.10e-02
Rab regulation of trafficking	117	4.24e-02	1.47e-01	0.13400	2.94e-02	1.30e-01	5.83e-01	1.48e-02
Dermatan sulfate biosynthesis	11	4.26e-02	1.48e-01	0.44300	3.53e-01	-2.69e-01	4.28e-02	1.23e-01
Netrin-1 signaling	49	4.27e-02	1.48e-01	0.20700	-1.28e-02	-2.07e-01	8.77e-01	1.24e-02
Regulation of APC/C activators between G1/S and early anaphase	77	4.31e-02	1.49e-01	0.16400	3.49e-02	1.61e-01	5.96e-01	1.49e-02
Toll-like Receptor Cascades	138	4.32e-02	1.49e-01	0.12400	-2.53e-02	1.22e-01	6.07e-01	1.36e-02
Post-translational protein modification	1267	4.44e-02	1.52e-01	0.04180	9.04e-03	4.08e-02	5.91e-01	1.55e-02
E3 ubiquitin ligases ubiquitinate target proteins	46	4.55e-02	1.56e-01	0.21100	-2.11e-01	-1.55e-02	1.34e-02	8.56e-01
Semaphorin interactions	63	4.61e-02	1.58e-01	0.17800	-1.56e-01	-8.62e-02	3.20e-02	2.37e-01
Initial triggering of complement	45	4.65e-02	1.59e-01	0.21100	-1.20e-01	-1.73e-01	1.63e-01	4.50e-02
Eukaryotic Translation Termination	69	4.69e-02	1.60e-01	0.17200	1.71e-01	1.83e-02	1.42e-02	7.93e-01
Interleukin-10 signaling	38	4.74e-02	1.60e-01	0.22900	-1.17e-01	-1.97e-01	2.14e-01	3.60e-02
Resolution of D-loop Structures through Holliday Junction Intermediates	32	4.74e-02	1.60e-01	0.25600	1.47e-01	-2.09e-01	1.51e-01	4.05e-02
Regulation of pyruvate dehydrogenase (PDH) complex	15	4.75e-02	1.60e-01	0.37100	-1.17e-01	3.52e-01	4.33e-01	1.81e-02
Regulation of TP53 Activity through Phosphorylation	84	4.80e-02	1.62e-01	0.15800	8.96e-02	-1.30e-01	1.56e-01	3.99e-02
Diseases of glycosylation	132	4.92e-02	1.65e-01	0.12600	9.42e-02	-8.31e-02	6.20e-02	9.96e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	14	4.94e-02	1.65e-01	0.37400	-1.98e-01	-3.17e-01	2.00e-01	4.01e-02
Toll Like Receptor 4 (TLR4) Cascade	114	4.94e-02	1.65e-01	0.13300	-1.53e-02	1.33e-01	7.78e-01	1.45e-02
Metabolism of nucleotides	94	4.94e-02	1.65e-01	0.14400	9.88e-02	1.05e-01	9.80e-02	7.83e-02
Diseases of signal transduction by growth factor receptors and second messengers	363	4.95e-02	1.65e-01	0.07600	-4.00e-02	6.47e-02	1.92e-01	3.47e-02
Establishment of Sister Chromatid Cohesion	11	4.97e-02	1.65e-01	0.43200	2.38e-01	-3.61e-01	1.71e-01	3.84e-02
Syndecan interactions	19	5.00e-02	1.66e-01	0.32900	1.71e-01	-2.80e-01	1.96e-01	3.44e-02
RNA Polymerase I Transcription Termination	28	5.07e-02	1.68e-01	0.26400	8.13e-02	2.51e-01	4.56e-01	2.13e-02
PI Metabolism	80	5.08e-02	1.68e-01	0.15600	5.36e-02	1.47e-01	4.08e-01	2.31e-02
Mitotic Telophase/Cytokinesis	13	5.15e-02	1.70e-01	0.38800	-7.65e-02	-3.80e-01	6.33e-01	1.76e-02
Unfolded Protein Response (UPR)	91	5.25e-02	1.73e-01	0.14600	5.88e-02	1.33e-01	3.33e-01	2.80e-02
DNA Replication Pre-Initiation	81	5.28e-02	1.73e-01	0.15400	9.67e-02	1.19e-01	1.32e-01	6.33e-02
Other interleukin signaling	21	5.31e-02	1.74e-01	0.30300	-2.88e-01	-9.25e-02	2.22e-02	4.63e-01
Acetylcholine Neurotransmitter Release Cycle	15	5.40e-02	1.76e-01	0.35800	7.84e-02	3.49e-01	5.99e-01	1.92e-02
Diseases associated with O-glycosylation of proteins	60	5.40e-02	1.76e-01	0.18100	2.84e-02	-1.79e-01	7.03e-01	1.66e-02
IL-6-type cytokine receptor ligand interactions	17	5.48e-02	1.78e-01	0.34100	-3.22e-01	1.12e-01	2.16e-02	4.25e-01
ER Quality Control Compartment (ERQC)	19	5.50e-02	1.78e-01	0.31500	2.06e-01	2.38e-01	1.20e-01	7.29e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	5.61e-02	1.82e-01	0.31400	-2.17e-01	2.28e-01	9.34e-02	7.77e-02
C-type lectin receptors (CLRs)	125	5.69e-02	1.84e-01	0.12300	3.59e-02	1.18e-01	4.89e-01	2.32e-02
Influenza Viral RNA Transcription and Replication	108	5.71e-02	1.84e-01	0.13200	1.28e-01	3.21e-02	2.12e-02	5.64e-01
Interleukin-6 signaling	11	5.76e-02	1.85e-01	0.42000	-1.67e-01	3.86e-01	3.38e-01	2.67e-02
RAF-independent MAPK1/3 activation	23	5.82e-02	1.87e-01	0.29100	-2.53e-01	1.43e-01	3.55e-02	2.36e-01
Creation of C4 and C2 activators	38	5.91e-02	1.89e-01	0.22200	-3.30e-02	-2.20e-01	7.25e-01	1.92e-02
TRAF6 mediated NF-kB activation	19	5.94e-02	1.90e-01	0.31500	-6.54e-03	3.15e-01	9.61e-01	1.75e-02
Neurotransmitter clearance	10	6.05e-02	1.93e-01	0.42800	-3.84e-01	-1.89e-01	3.57e-02	3.02e-01
Global Genome Nucleotide Excision Repair (GG-NER)	82	6.11e-02	1.94e-01	0.15300	-9.65e-02	1.19e-01	1.31e-01	6.25e-02
Processing of Capped Intron-Containing Pre-mRNA	227	6.18e-02	1.96e-01	0.08970	-7.18e-02	-5.38e-02	6.26e-02	1.63e-01
Sialic acid metabolism	31	6.25e-02	1.98e-01	0.24300	2.36e-01	5.59e-02	2.29e-02	5.90e-01
Antimicrobial peptides	45	6.26e-02	1.98e-01	0.20300	-2.02e-01	2.05e-02	1.89e-02	8.12e-01
Interleukin-20 family signaling	20	6.33e-02	1.99e-01	0.30700	-1.16e-01	2.84e-01	3.69e-01	2.81e-02
Chondroitin sulfate biosynthesis	20	6.34e-02	1.99e-01	0.30800	2.04e-01	-2.30e-01	1.14e-01	7.48e-02
SARS-CoV-1 Infection	47	6.34e-02	1.99e-01	0.20000	-8.96e-02	1.79e-01	2.88e-01	3.36e-02
L13a-mediated translational silencing of Ceruloplasmin expression	84	6.45e-02	2.02e-01	0.14600	1.26e-01	7.39e-02	4.63e-02	2.42e-01
Immune System	1894	6.53e-02	2.04e-01	0.03310	-3.09e-02	1.20e-02	2.80e-02	3.91e-01
Condensation of Prometaphase Chromosomes	10	6.54e-02	2.04e-01	0.42100	-2.06e-01	-3.68e-01	2.60e-01	4.42e-02
Constitutive Signaling by AKT1 E17K in Cancer	25	6.63e-02	2.06e-01	0.27200	-9.44e-02	2.55e-01	4.14e-01	2.75e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	86	6.63e-02	2.06e-01	0.14300	1.23e-01	7.42e-02	4.91e-02	2.34e-01
CDC6 association with the ORC:origin complex	11	6.74e-02	2.08e-01	0.40900	1.73e-01	-3.70e-01	3.20e-01	3.34e-02
DAP12 interactions	38	6.74e-02	2.08e-01	0.21800	1.15e-02	-2.18e-01	9.03e-01	2.02e-02
Myogenesis	28	6.82e-02	2.10e-01	0.25200	-2.51e-01	-2.14e-02	2.13e-02	8.45e-01
Budding and maturation of HIV virion	25	6.83e-02	2.10e-01	0.27100	-1.69e-01	2.12e-01	1.43e-01	6.63e-02
Ca2+ pathway	60	6.92e-02	2.12e-01	0.17200	-1.85e-02	-1.71e-01	8.05e-01	2.20e-02
G0 and Early G1	27	7.02e-02	2.15e-01	0.25600	2.27e-03	-2.56e-01	9.84e-01	2.12e-02
Formation of the cornified envelope	34	7.02e-02	2.15e-01	0.22900	-2.26e-01	3.73e-02	2.24e-02	7.07e-01
Meiotic synapsis	41	7.04e-02	2.15e-01	0.20700	-4.48e-02	-2.02e-01	6.19e-01	2.55e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	17	7.10e-02	2.16e-01	0.32000	7.03e-02	3.12e-01	6.16e-01	2.58e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	7.14e-02	2.17e-01	0.32600	1.59e-01	-2.85e-01	2.57e-01	4.23e-02
Synthesis of PC	27	7.16e-02	2.17e-01	0.25400	-2.53e-01	-3.09e-02	2.32e-02	7.81e-01
Oncogenic MAPK signaling	77	7.17e-02	2.17e-01	0.15100	-1.50e-01	-1.68e-02	2.30e-02	7.99e-01
Molecules associated with elastic fibres	28	7.22e-02	2.18e-01	0.25400	2.02e-01	-1.54e-01	6.49e-02	1.58e-01
Diseases of carbohydrate metabolism	32	7.28e-02	2.19e-01	0.23700	-1.84e-01	1.50e-01	7.23e-02	1.42e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	11	7.42e-02	2.23e-01	0.40200	2.07e-01	-3.45e-01	2.34e-01	4.77e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	13	7.48e-02	2.24e-01	0.36100	1.14e-01	3.43e-01	4.76e-01	3.23e-02
Receptor Mediated Mitophagy	11	7.56e-02	2.26e-01	0.40100	-2.37e-01	3.24e-01	1.73e-01	6.32e-02
Glutathione conjugation	30	7.63e-02	2.27e-01	0.23600	-1.84e-01	-1.48e-01	8.15e-02	1.61e-01
PI-3K cascade:FGFR3	16	7.63e-02	2.27e-01	0.32800	3.28e-01	-7.83e-03	2.33e-02	9.57e-01
Downstream signaling of activated FGFR3	23	7.72e-02	2.29e-01	0.27500	2.63e-01	-7.82e-02	2.88e-02	5.16e-01
RNA Polymerase I Transcription Initiation	44	7.72e-02	2.29e-01	0.19800	-1.91e-02	1.97e-01	8.27e-01	2.39e-02
Signaling by Insulin receptor	73	7.78e-02	2.30e-01	0.15300	1.52e-01	8.91e-03	2.44e-02	8.95e-01
WNT ligand biogenesis and trafficking	25	7.80e-02	2.30e-01	0.25800	-8.98e-02	-2.42e-01	4.37e-01	3.60e-02
APC/C:Cdc20 mediated degradation of mitotic proteins	72	7.82e-02	2.30e-01	0.15300	1.57e-02	1.53e-01	8.18e-01	2.52e-02
Telomere Maintenance	73	7.83e-02	2.30e-01	0.15300	-5.90e-03	-1.52e-01	9.31e-01	2.43e-02
Cleavage of the damaged purine	20	7.90e-02	2.31e-01	0.29300	6.53e-02	-2.85e-01	6.13e-01	2.71e-02
Depurination	20	7.90e-02	2.31e-01	0.29300	6.53e-02	-2.85e-01	6.13e-01	2.71e-02
Recognition and association of DNA glycosylase with site containing an affected purine	20	7.90e-02	2.31e-01	0.29300	6.53e-02	-2.85e-01	6.13e-01	2.71e-02
Rap1 signalling	14	7.93e-02	2.31e-01	0.35100	-1.13e-01	3.32e-01	4.63e-01	3.16e-02
RHO GTPases activate PAKs	21	8.06e-02	2.35e-01	0.27900	-2.44e-01	-1.36e-01	5.30e-02	2.80e-01
Signaling by NTRK3 (TRKC)	17	8.12e-02	2.35e-01	0.31300	3.09e-01	4.36e-02	2.72e-02	7.56e-01
E2F mediated regulation of DNA replication	21	8.14e-02	2.35e-01	0.28400	5.56e-02	-2.78e-01	6.59e-01	2.73e-02
FGFR3 mutant receptor activation	10	8.16e-02	2.35e-01	0.40900	4.09e-01	-2.63e-04	2.52e-02	9.99e-01
Signaling by activated point mutants of FGFR3	10	8.16e-02	2.35e-01	0.40900	4.09e-01	-2.63e-04	2.52e-02	9.99e-01
Dual incision in TC-NER	61	8.16e-02	2.35e-01	0.16800	-1.09e-01	1.28e-01	1.43e-01	8.29e-02
RIP-mediated NFkB activation via ZBP1	15	8.22e-02	2.36e-01	0.32900	2.61e-01	2.00e-01	8.01e-02	1.81e-01
Packaging Of Telomere Ends	16	8.22e-02	2.36e-01	0.32300	2.95e-03	-3.23e-01	9.84e-01	2.54e-02
YAP1- and WWTR1 (TAZ)-stimulated gene expression	14	8.24e-02	2.36e-01	0.34900	-1.69e-01	3.06e-01	2.74e-01	4.78e-02
G beta:gamma signalling through BTK	17	8.35e-02	2.39e-01	0.31600	1.87e-01	-2.55e-01	1.82e-01	6.82e-02
cGMP effects	15	8.38e-02	2.39e-01	0.32700	-2.61e-01	-1.98e-01	8.01e-02	1.85e-01
Phase 4 - resting membrane potential	18	8.39e-02	2.39e-01	0.29900	-1.97e-01	-2.24e-01	1.48e-01	9.93e-02
TICAM1-dependent activation of IRF3/IRF7	10	8.43e-02	2.40e-01	0.40100	1.83e-01	3.57e-01	3.16e-01	5.06e-02
Tandem pore domain potassium channels	11	8.44e-02	2.40e-01	0.38200	-2.88e-01	-2.50e-01	9.80e-02	1.51e-01
PRC2 methylates histones and DNA	23	8.55e-02	2.42e-01	0.26300	-1.61e-01	-2.08e-01	1.80e-01	8.41e-02
Transcriptional regulation of granulopoiesis	40	8.62e-02	2.43e-01	0.20100	-4.99e-02	-1.95e-01	5.85e-01	3.33e-02
Signaling by TGFB family members	96	8.64e-02	2.43e-01	0.12900	7.98e-02	1.01e-01	1.77e-01	8.68e-02
Synthesis of PIPs at the plasma membrane	51	8.68e-02	2.43e-01	0.18100	-7.31e-02	1.65e-01	3.66e-01	4.10e-02
Selenocysteine synthesis	68	8.70e-02	2.43e-01	0.15500	1.55e-01	-1.46e-02	2.75e-02	8.35e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	8.74e-02	2.43e-01	0.17600	-1.55e-01	8.35e-02	4.93e-02	2.88e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	8.74e-02	2.43e-01	0.17600	-1.55e-01	8.35e-02	4.93e-02	2.88e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	8.74e-02	2.43e-01	0.17600	-1.55e-01	8.35e-02	4.93e-02	2.88e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	8.74e-02	2.43e-01	0.17600	-1.55e-01	8.35e-02	4.93e-02	2.88e-01
Signaling by NOTCH1 in Cancer	54	8.74e-02	2.43e-01	0.17600	-1.55e-01	8.35e-02	4.93e-02	2.88e-01
Switching of origins to a post-replicative state	87	8.79e-02	2.44e-01	0.13500	6.49e-02	1.19e-01	2.96e-01	5.61e-02
Intra-Golgi and retrograde Golgi-to-ER traffic	176	8.84e-02	2.45e-01	0.09510	4.66e-02	8.29e-02	2.86e-01	5.80e-02
NCAM1 interactions	31	8.87e-02	2.45e-01	0.22900	3.97e-02	-2.26e-01	7.02e-01	2.94e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	23	8.89e-02	2.45e-01	0.26700	-7.68e-02	2.56e-01	5.24e-01	3.37e-02
DNA Double-Strand Break Repair	131	8.91e-02	2.45e-01	0.11200	3.39e-02	-1.07e-01	5.03e-01	3.46e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	8.95e-02	2.45e-01	0.37100	-2.35e-01	2.87e-01	1.58e-01	8.47e-02
alpha-linolenic acid (ALA) metabolism	12	8.95e-02	2.45e-01	0.37100	-2.35e-01	2.87e-01	1.58e-01	8.47e-02
Glycogen breakdown (glycogenolysis)	14	8.96e-02	2.45e-01	0.34000	-3.28e-02	3.38e-01	8.31e-01	2.84e-02
PKA activation	16	8.96e-02	2.45e-01	0.31900	-3.09e-01	8.02e-02	3.23e-02	5.79e-01
Integrin signaling	27	8.99e-02	2.46e-01	0.24300	-2.42e-01	-2.83e-02	2.99e-02	7.99e-01
Interleukin-27 signaling	11	9.10e-02	2.48e-01	0.38400	-8.65e-02	3.74e-01	6.20e-01	3.19e-02
Erythrocytes take up carbon dioxide and release oxygen	11	9.34e-02	2.53e-01	0.38400	-1.78e-01	3.40e-01	3.08e-01	5.09e-02
O2/CO2 exchange in erythrocytes	11	9.34e-02	2.53e-01	0.38400	-1.78e-01	3.40e-01	3.08e-01	5.09e-02
Diseases associated with glycosaminoglycan metabolism	39	9.35e-02	2.53e-01	0.20400	1.76e-01	-1.03e-01	5.70e-02	2.66e-01
FGFR3 ligand binding and activation	11	9.36e-02	2.53e-01	0.37800	3.77e-01	2.37e-02	3.02e-02	8.92e-01
FGFR3c ligand binding and activation	11	9.36e-02	2.53e-01	0.37800	3.77e-01	2.37e-02	3.02e-02	8.92e-01
VEGFR2 mediated cell proliferation	19	9.38e-02	2.53e-01	0.29000	7.10e-02	-2.81e-01	5.92e-01	3.37e-02
Diseases of DNA repair	10	9.41e-02	2.53e-01	0.40000	3.83e-01	-1.16e-01	3.61e-02	5.24e-01
O-linked glycosylation of mucins	53	9.56e-02	2.56e-01	0.17500	1.28e-01	-1.19e-01	1.07e-01	1.35e-01
Diseases associated with glycosylation precursor biosynthesis	18	9.57e-02	2.56e-01	0.29300	6.75e-02	2.85e-01	6.20e-01	3.63e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	20	9.65e-02	2.58e-01	0.28300	-2.01e-01	1.99e-01	1.19e-01	1.23e-01
PD-1 signaling	18	9.69e-02	2.59e-01	0.29800	-2.38e-01	1.80e-01	8.02e-02	1.87e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	9.71e-02	2.59e-01	0.33100	-6.10e-02	-3.26e-01	6.93e-01	3.48e-02
Signaling by NTRK2 (TRKB)	25	9.76e-02	2.60e-01	0.25300	1.81e-01	-1.76e-01	1.17e-01	1.27e-01
Activation of SMO	18	9.81e-02	2.61e-01	0.29600	2.76e-01	-1.09e-01	4.30e-02	4.24e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	12	9.89e-02	2.62e-01	0.35800	1.31e-02	3.58e-01	9.37e-01	3.18e-02
Base Excision Repair	54	9.91e-02	2.62e-01	0.17000	4.65e-02	-1.64e-01	5.55e-01	3.72e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane	50	9.93e-02	2.62e-01	0.17700	-4.68e-02	1.71e-01	5.67e-01	3.68e-02
Formation of a pool of free 40S subunits	76	9.98e-02	2.63e-01	0.14100	1.29e-01	5.74e-02	5.25e-02	3.87e-01
rRNA processing	186	1.01e-01	2.67e-01	0.09030	8.56e-02	2.85e-02	4.42e-02	5.03e-01
RNA Polymerase III Transcription Initiation	32	1.02e-01	2.69e-01	0.22100	-1.56e-01	1.57e-01	1.27e-01	1.24e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	85	1.02e-01	2.69e-01	0.13400	-5.65e-03	1.34e-01	9.28e-01	3.28e-02
O-linked glycosylation	100	1.03e-01	2.70e-01	0.12500	7.74e-02	-9.84e-02	1.82e-01	8.92e-02
Vasopressin regulates renal water homeostasis via Aquaporins	40	1.03e-01	2.70e-01	0.19500	-1.94e-01	-4.60e-03	3.33e-02	9.60e-01
SHC-mediated cascade:FGFR3	16	1.04e-01	2.72e-01	0.30700	3.07e-01	-7.04e-03	3.35e-02	9.61e-01
RHO GTPases activate CIT	19	1.04e-01	2.72e-01	0.27800	-1.55e-01	-2.31e-01	2.42e-01	8.18e-02
Signaling by Leptin	11	1.05e-01	2.73e-01	0.37500	-2.33e-01	2.93e-01	1.80e-01	9.26e-02
Signaling by BRAF and RAF fusions	61	1.06e-01	2.73e-01	0.15700	-1.57e-01	8.06e-03	3.41e-02	9.13e-01
Negative regulation of MAPK pathway	42	1.06e-01	2.73e-01	0.19200	-1.41e-01	1.30e-01	1.14e-01	1.45e-01
Notch-HLH transcription pathway	26	1.06e-01	2.73e-01	0.23700	-2.10e-01	-1.11e-01	6.42e-02	3.28e-01
Regulated proteolysis of p75NTR	11	1.06e-01	2.73e-01	0.37000	-3.68e-01	4.04e-02	3.47e-02	8.16e-01
Neuronal System	366	1.06e-01	2.74e-01	0.06390	-5.87e-02	-2.52e-02	5.43e-02	4.09e-01
Retrograde neurotrophin signalling	14	1.07e-01	2.74e-01	0.32500	5.12e-02	3.21e-01	7.40e-01	3.76e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	1.07e-01	2.74e-01	0.35400	6.24e-02	-3.49e-01	7.08e-01	3.64e-02
Uptake and actions of bacterial toxins	26	1.07e-01	2.75e-01	0.24300	-1.63e-01	1.80e-01	1.51e-01	1.11e-01
Golgi Associated Vesicle Biogenesis	54	1.08e-01	2.76e-01	0.16700	-3.52e-02	1.63e-01	6.55e-01	3.81e-02
HuR (ELAVL1) binds and stabilizes mRNA	10	1.08e-01	2.76e-01	0.37900	-2.34e-01	-2.99e-01	2.01e-01	1.02e-01
FLT3 Signaling	277	1.09e-01	2.76e-01	0.07330	1.14e-02	7.24e-02	7.45e-01	3.83e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	1.09e-01	2.76e-01	0.31400	1.08e-02	3.13e-01	9.42e-01	3.56e-02
activated TAK1 mediates p38 MAPK activation	18	1.09e-01	2.76e-01	0.28500	5.17e-02	2.80e-01	7.04e-01	3.94e-02
Membrane binding and targetting of GAG proteins	13	1.09e-01	2.76e-01	0.34200	-2.66e-01	2.14e-01	9.62e-02	1.81e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	1.09e-01	2.76e-01	0.34200	-2.66e-01	2.14e-01	9.62e-02	1.81e-01
Signaling by Interleukins	403	1.09e-01	2.76e-01	0.06150	-9.72e-03	6.07e-02	7.38e-01	3.69e-02
Surfactant metabolism	24	1.10e-01	2.76e-01	0.24900	-4.89e-02	2.44e-01	6.78e-01	3.85e-02
mRNA 3'-end processing	55	1.10e-01	2.76e-01	0.16400	1.20e-02	-1.64e-01	8.78e-01	3.60e-02
Physiological factors	12	1.11e-01	2.76e-01	0.34800	4.19e-02	3.46e-01	8.02e-01	3.80e-02
HIV Transcription Initiation	42	1.11e-01	2.76e-01	0.18400	1.48e-01	1.10e-01	9.75e-02	2.17e-01
RNA Polymerase II HIV Promoter Escape	42	1.11e-01	2.76e-01	0.18400	1.48e-01	1.10e-01	9.75e-02	2.17e-01
RNA Polymerase II Promoter Escape	42	1.11e-01	2.76e-01	0.18400	1.48e-01	1.10e-01	9.75e-02	2.17e-01
RNA Polymerase II Transcription Initiation	42	1.11e-01	2.76e-01	0.18400	1.48e-01	1.10e-01	9.75e-02	2.17e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	42	1.11e-01	2.76e-01	0.18400	1.48e-01	1.10e-01	9.75e-02	2.17e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	42	1.11e-01	2.76e-01	0.18400	1.48e-01	1.10e-01	9.75e-02	2.17e-01
Dissolution of Fibrin Clot	11	1.11e-01	2.76e-01	0.36600	3.27e-02	-3.64e-01	8.51e-01	3.64e-02
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	49	1.12e-01	2.77e-01	0.17400	1.69e-01	-3.93e-02	4.03e-02	6.34e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	27	1.14e-01	2.82e-01	0.23000	3.90e-02	2.27e-01	7.25e-01	4.11e-02
Interferon gamma signaling	77	1.14e-01	2.82e-01	0.13800	-4.28e-02	1.32e-01	5.16e-01	4.58e-02
Senescence-Associated Secretory Phenotype (SASP)	56	1.15e-01	2.82e-01	0.16000	-3.72e-02	-1.55e-01	6.30e-01	4.44e-02
ZBP1(DAI) mediated induction of type I IFNs	19	1.15e-01	2.83e-01	0.27100	1.87e-01	1.97e-01	1.59e-01	1.37e-01
L1CAM interactions	98	1.16e-01	2.83e-01	0.12300	-9.85e-02	7.39e-02	9.22e-02	2.06e-01
TNF signaling	43	1.16e-01	2.83e-01	0.18400	-2.76e-02	1.82e-01	7.54e-01	3.93e-02
Cellular Senescence	136	1.16e-01	2.83e-01	0.10200	-3.46e-02	-9.61e-02	4.86e-01	5.32e-02
ATF6 (ATF6-alpha) activates chaperones	12	1.16e-01	2.83e-01	0.35000	-1.54e-01	3.14e-01	3.56e-01	5.96e-02
Acetylcholine binding and downstream events	11	1.16e-01	2.83e-01	0.35600	-2.61e-01	-2.42e-01	1.34e-01	1.65e-01
Postsynaptic nicotinic acetylcholine receptors	11	1.16e-01	2.83e-01	0.35600	-2.61e-01	-2.42e-01	1.34e-01	1.65e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	1.17e-01	2.84e-01	0.22500	-1.77e-01	1.40e-01	9.99e-02	1.92e-01
Trafficking of AMPA receptors	29	1.17e-01	2.84e-01	0.22500	-1.77e-01	1.40e-01	9.99e-02	1.92e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	73	1.18e-01	2.86e-01	0.14000	5.67e-03	1.40e-01	9.33e-01	3.92e-02
Non-integrin membrane-ECM interactions	41	1.20e-01	2.89e-01	0.18800	8.59e-02	-1.67e-01	3.41e-01	6.36e-02
Transport of Mature Transcript to Cytoplasm	80	1.20e-01	2.90e-01	0.13400	2.93e-02	-1.31e-01	6.51e-01	4.34e-02
Transport to the Golgi and subsequent modification	154	1.21e-01	2.92e-01	0.09580	3.70e-03	9.58e-02	9.37e-01	4.04e-02
Translation of structural proteins	27	1.23e-01	2.95e-01	0.23100	-1.76e-01	1.50e-01	1.13e-01	1.79e-01
RAF activation	32	1.24e-01	2.97e-01	0.21100	-9.34e-02	1.90e-01	3.61e-01	6.36e-02
Kinesins	40	1.24e-01	2.98e-01	0.18500	-1.80e-01	-4.27e-02	4.85e-02	6.40e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	1.25e-01	3.00e-01	0.22700	-2.26e-01	1.78e-02	4.18e-02	8.73e-01
Phospholipid metabolism	202	1.26e-01	3.01e-01	0.08340	-9.63e-03	8.29e-02	8.14e-01	4.25e-02
Aquaporin-mediated transport	48	1.26e-01	3.01e-01	0.17000	-1.70e-01	1.10e-02	4.20e-02	8.95e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	89	1.28e-01	3.04e-01	0.12400	1.24e-01	9.21e-03	4.36e-02	8.81e-01
Nonsense-Mediated Decay (NMD)	89	1.28e-01	3.04e-01	0.12400	1.24e-01	9.21e-03	4.36e-02	8.81e-01
Telomere C-strand synthesis initiation	13	1.28e-01	3.04e-01	0.32700	1.00e-01	-3.12e-01	5.32e-01	5.18e-02
Beta-catenin independent WNT signaling	141	1.28e-01	3.04e-01	0.09820	2.28e-02	9.56e-02	6.40e-01	5.03e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37	1.29e-01	3.05e-01	0.19500	-1.37e-01	1.39e-01	1.49e-01	1.44e-01
Post NMDA receptor activation events	59	1.29e-01	3.05e-01	0.15300	-2.86e-02	1.50e-01	7.04e-01	4.57e-02
TNFs bind their physiological receptors	26	1.31e-01	3.08e-01	0.22700	-6.22e-02	-2.18e-01	5.83e-01	5.42e-02
G beta:gamma signalling through CDC42	19	1.31e-01	3.09e-01	0.26700	-8.39e-03	-2.67e-01	9.50e-01	4.42e-02
Negative regulation of NMDA receptor-mediated neuronal transmission	20	1.32e-01	3.10e-01	0.25900	3.00e-02	2.57e-01	8.17e-01	4.63e-02
Muscle contraction	176	1.33e-01	3.11e-01	0.08920	-6.23e-02	6.38e-02	1.54e-01	1.45e-01
DAP12 signaling	29	1.33e-01	3.11e-01	0.21700	5.82e-02	-2.09e-01	5.88e-01	5.12e-02
Pre-NOTCH Expression and Processing	63	1.33e-01	3.11e-01	0.14400	-1.09e-01	-9.46e-02	1.35e-01	1.94e-01
MAPK3 (ERK1) activation	10	1.33e-01	3.11e-01	0.37100	-3.22e-01	1.85e-01	7.80e-02	3.11e-01
Golgi-to-ER retrograde transport	111	1.33e-01	3.11e-01	0.11100	-3.06e-02	1.07e-01	5.78e-01	5.18e-02
FOXO-mediated transcription	64	1.35e-01	3.15e-01	0.14600	-1.40e-01	4.08e-02	5.30e-02	5.72e-01
Negative regulators of DDX58/IFIH1 signaling	31	1.36e-01	3.16e-01	0.21000	-8.90e-02	1.90e-01	3.91e-01	6.75e-02
Regulation of TP53 Activity through Acetylation	28	1.37e-01	3.19e-01	0.22000	-1.95e-01	1.03e-01	7.47e-02	3.46e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	1.38e-01	3.20e-01	0.24300	-1.87e-01	1.55e-01	1.20e-01	1.98e-01
FGFR1 mutant receptor activation	28	1.38e-01	3.20e-01	0.21400	1.21e-01	1.77e-01	2.67e-01	1.06e-01
The phototransduction cascade	31	1.39e-01	3.21e-01	0.20800	8.37e-02	-1.91e-01	4.20e-01	6.59e-02
Nitric oxide stimulates guanylate cyclase	19	1.39e-01	3.22e-01	0.25900	-1.67e-01	-1.98e-01	2.08e-01	1.35e-01
Activation of the AP-1 family of transcription factors	10	1.40e-01	3.22e-01	0.35700	2.28e-01	2.75e-01	2.12e-01	1.32e-01
HS-GAG degradation	20	1.40e-01	3.23e-01	0.25300	-1.30e-01	-2.17e-01	3.15e-01	9.34e-02
Olfactory Signaling Pathway	90	1.42e-01	3.27e-01	0.11900	-6.33e-02	-1.01e-01	3.00e-01	9.91e-02
Listeria monocytogenes entry into host cells	19	1.44e-01	3.29e-01	0.26400	-2.33e-01	1.24e-01	7.84e-02	3.49e-01
Transport of small molecules	678	1.44e-01	3.30e-01	0.04460	-4.94e-03	4.44e-02	8.27e-01	4.98e-02
IGF1R signaling cascade	48	1.46e-01	3.33e-01	0.16500	1.62e-01	-3.01e-02	5.26e-02	7.18e-01
Transcriptional regulation of white adipocyte differentiation	81	1.46e-01	3.34e-01	0.12500	-1.24e-01	-2.00e-02	5.41e-02	7.56e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	1.48e-01	3.36e-01	0.27800	1.64e-01	-2.24e-01	2.43e-01	1.09e-01
Metabolism of carbohydrates	274	1.48e-01	3.36e-01	0.06820	1.77e-02	6.58e-02	6.15e-01	6.11e-02
DSCAM interactions	11	1.48e-01	3.36e-01	0.34400	1.58e-01	-3.06e-01	3.64e-01	7.91e-02
Unwinding of DNA	12	1.48e-01	3.36e-01	0.32400	-4.83e-02	-3.21e-01	7.72e-01	5.45e-02
Chemokine receptors bind chemokines	42	1.49e-01	3.37e-01	0.17200	-1.32e-01	-1.10e-01	1.40e-01	2.17e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	1.50e-01	3.38e-01	0.24900	-2.32e-01	-9.08e-02	7.24e-02	4.82e-01
tRNA processing	118	1.51e-01	3.40e-01	0.10300	2.88e-02	9.88e-02	5.90e-01	6.40e-02
TCF dependent signaling in response to WNT	176	1.51e-01	3.40e-01	0.08600	-3.68e-02	7.77e-02	4.00e-01	7.55e-02
Other semaphorin interactions	19	1.52e-01	3.42e-01	0.25400	-1.57e-01	-1.99e-01	2.35e-01	1.33e-01
Interferon Signaling	177	1.53e-01	3.43e-01	0.08570	-6.92e-02	5.06e-02	1.13e-01	2.46e-01
tRNA modification in the nucleus and cytosol	42	1.53e-01	3.43e-01	0.17100	8.96e-02	1.45e-01	3.15e-01	1.04e-01
Regulation of beta-cell development	36	1.53e-01	3.43e-01	0.18500	-1.81e-01	-4.09e-02	6.06e-02	6.71e-01
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	10	1.54e-01	3.43e-01	0.35800	1.59e-01	-3.20e-01	3.83e-01	7.97e-02
Postmitotic nuclear pore complex (NPC) reformation	26	1.54e-01	3.43e-01	0.22100	2.09e-01	-7.10e-02	6.46e-02	5.31e-01
Transcriptional regulation of pluripotent stem cells	28	1.55e-01	3.45e-01	0.21200	-2.10e-01	2.77e-02	5.47e-02	8.00e-01
NS1 Mediated Effects on Host Pathways	40	1.55e-01	3.45e-01	0.17800	1.71e-01	-4.92e-02	6.15e-02	5.91e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	24	1.56e-01	3.47e-01	0.22900	-8.49e-02	2.13e-01	4.72e-01	7.06e-02
Signaling by TGF-beta Receptor Complex	69	1.57e-01	3.48e-01	0.13200	8.14e-02	1.04e-01	2.43e-01	1.35e-01
Mitotic Metaphase and Anaphase	218	1.57e-01	3.48e-01	0.07520	7.35e-02	1.58e-02	6.17e-02	6.87e-01
Translocation of ZAP-70 to Immunological synapse	13	1.58e-01	3.49e-01	0.30900	-3.04e-01	5.71e-02	5.78e-02	7.21e-01
Glutamate and glutamine metabolism	13	1.58e-01	3.49e-01	0.30400	1.21e-01	2.79e-01	4.48e-01	8.16e-02
Zinc transporters	17	1.59e-01	3.50e-01	0.27100	2.56e-01	-9.01e-02	6.79e-02	5.20e-01
Lysosome Vesicle Biogenesis	34	1.59e-01	3.51e-01	0.19000	3.83e-03	1.90e-01	9.69e-01	5.56e-02
Metabolism of RNA	629	1.59e-01	3.51e-01	0.04500	-1.57e-03	4.49e-02	9.47e-01	5.53e-02
Signaling by FGFR3 in disease	20	1.60e-01	3.51e-01	0.25000	2.30e-01	-9.77e-02	7.51e-02	4.50e-01
Signaling by FGFR3 point mutants in cancer	20	1.60e-01	3.51e-01	0.25000	2.30e-01	-9.77e-02	7.51e-02	4.50e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	12	1.61e-01	3.52e-01	0.31400	-2.26e-01	-2.18e-01	1.75e-01	1.91e-01
Signaling by NOTCH3	44	1.61e-01	3.52e-01	0.16800	-1.63e-01	3.93e-02	6.16e-02	6.52e-01
Pre-NOTCH Transcription and Translation	47	1.61e-01	3.52e-01	0.15900	-8.47e-02	-1.34e-01	3.15e-01	1.11e-01
Vitamin D (calciferol) metabolism	11	1.62e-01	3.54e-01	0.33000	-3.25e-01	-5.99e-02	6.23e-02	7.31e-01
Interleukin-35 Signalling	11	1.63e-01	3.54e-01	0.33300	-5.39e-02	3.29e-01	7.57e-01	5.89e-02
Nucleobase catabolism	35	1.64e-01	3.56e-01	0.18300	1.48e-01	1.08e-01	1.30e-01	2.70e-01
RAF/MAP kinase cascade	263	1.65e-01	3.59e-01	0.06770	1.18e-02	6.67e-02	7.43e-01	6.31e-02
ROS and RNS production in phagocytes	34	1.67e-01	3.61e-01	0.18600	1.74e-01	6.45e-02	7.89e-02	5.15e-01
CLEC7A (Dectin-1) induces NFAT activation	11	1.67e-01	3.62e-01	0.32600	-1.00e-01	-3.11e-01	5.65e-01	7.45e-02
Chondroitin sulfate/dermatan sulfate metabolism	49	1.69e-01	3.66e-01	0.15800	9.53e-02	-1.26e-01	2.49e-01	1.28e-01
Synthesis of PIPs at the Golgi membrane	17	1.71e-01	3.68e-01	0.26100	2.46e-01	8.83e-02	7.96e-02	5.29e-01
Platelet sensitization by LDL	16	1.73e-01	3.72e-01	0.26800	9.59e-02	2.50e-01	5.07e-01	8.35e-02
mRNA decay by 3' to 5' exoribonuclease	16	1.73e-01	3.72e-01	0.27000	-2.60e-02	-2.68e-01	8.57e-01	6.32e-02
Sphingolipid de novo biosynthesis	43	1.73e-01	3.72e-01	0.16300	-1.12e-01	-1.18e-01	2.04e-01	1.81e-01
Signaling by cytosolic FGFR1 fusion mutants	17	1.74e-01	3.72e-01	0.26000	7.29e-02	2.50e-01	6.03e-01	7.49e-02
Adrenaline,noradrenaline inhibits insulin secretion	27	1.75e-01	3.74e-01	0.21100	1.35e-01	-1.62e-01	2.26e-01	1.45e-01
Amine ligand-binding receptors	33	1.75e-01	3.74e-01	0.19000	1.06e-01	-1.58e-01	2.91e-01	1.17e-01
Transport of bile salts and organic acids, metal ions and amine compounds	78	1.75e-01	3.74e-01	0.12400	4.82e-02	-1.14e-01	4.62e-01	8.26e-02
Gap-filling DNA repair synthesis and ligation in TC-NER	60	1.77e-01	3.76e-01	0.14100	-7.67e-02	1.18e-01	3.04e-01	1.14e-01
MAPK1/MAPK3 signaling	269	1.77e-01	3.76e-01	0.06590	4.25e-03	6.58e-02	9.05e-01	6.38e-02
FRS-mediated FGFR3 signaling	18	1.77e-01	3.76e-01	0.25400	2.52e-01	-2.82e-02	6.37e-02	8.36e-01
Mitotic Anaphase	217	1.78e-01	3.78e-01	0.07280	7.13e-02	1.46e-02	7.06e-02	7.11e-01
Pre-NOTCH Processing in Golgi	18	1.79e-01	3.78e-01	0.25100	-2.47e-01	-4.43e-02	6.92e-02	7.45e-01
Collagen degradation	36	1.79e-01	3.78e-01	0.18100	1.14e-01	-1.41e-01	2.37e-01	1.44e-01
Presynaptic nicotinic acetylcholine receptors	10	1.80e-01	3.79e-01	0.33400	-2.09e-01	-2.60e-01	2.53e-01	1.54e-01
Sema4D in semaphorin signaling	24	1.80e-01	3.79e-01	0.21700	-2.15e-01	-3.08e-02	6.79e-02	7.94e-01
Sema4D induced cell migration and growth-cone collapse	20	1.80e-01	3.79e-01	0.23900	-2.39e-01	7.59e-04	6.41e-02	9.95e-01
Formation of RNA Pol II elongation complex	59	1.81e-01	3.79e-01	0.14100	-1.21e-01	7.24e-02	1.08e-01	3.36e-01
RNA Polymerase II Transcription Elongation	59	1.81e-01	3.79e-01	0.14100	-1.21e-01	7.24e-02	1.08e-01	3.36e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	46	1.81e-01	3.79e-01	0.15500	-1.22e-01	-9.65e-02	1.53e-01	2.58e-01
Inactivation, recovery and regulation of the phototransduction cascade	30	1.81e-01	3.79e-01	0.19700	7.19e-02	-1.83e-01	4.96e-01	8.24e-02
Phospholipase C-mediated cascade; FGFR3	11	1.82e-01	3.81e-01	0.32200	3.20e-01	-3.33e-02	6.58e-02	8.48e-01
Folding of actin by CCT/TriC	10	1.83e-01	3.82e-01	0.34100	-2.38e-01	2.45e-01	1.93e-01	1.80e-01
Purine ribonucleoside monophosphate biosynthesis	10	1.85e-01	3.84e-01	0.33300	1.11e-01	3.14e-01	5.44e-01	8.59e-02
Class B/2 (Secretin family receptors)	82	1.87e-01	3.88e-01	0.11800	4.92e-02	-1.08e-01	4.42e-01	9.21e-02
Diseases associated with the TLR signaling cascade	20	1.87e-01	3.88e-01	0.23900	2.24e-01	-8.19e-02	8.28e-02	5.26e-01
Diseases of Immune System	20	1.87e-01	3.88e-01	0.23900	2.24e-01	-8.19e-02	8.28e-02	5.26e-01
RNA Pol II CTD phosphorylation and interaction with CE	25	1.88e-01	3.89e-01	0.21000	3.45e-02	2.07e-01	7.65e-01	7.28e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	25	1.88e-01	3.89e-01	0.21000	3.45e-02	2.07e-01	7.65e-01	7.28e-02
Innate Immune System	942	1.89e-01	3.90e-01	0.03560	-3.38e-02	1.12e-02	8.03e-02	5.64e-01
DCC mediated attractive signaling	14	1.90e-01	3.92e-01	0.27700	-1.77e-01	-2.13e-01	2.51e-01	1.67e-01
Aspartate and asparagine metabolism	10	1.92e-01	3.95e-01	0.32700	2.10e-01	2.51e-01	2.51e-01	1.69e-01
Dual Incision in GG-NER	39	1.93e-01	3.97e-01	0.17000	-1.31e-01	1.09e-01	1.57e-01	2.40e-01
Downstream signaling of activated FGFR1	28	1.93e-01	3.97e-01	0.20100	1.63e-01	-1.16e-01	1.35e-01	2.86e-01
Potassium Channels	98	1.94e-01	3.97e-01	0.10500	-4.47e-02	-9.47e-02	4.45e-01	1.05e-01
ERBB2 Regulates Cell Motility	15	1.94e-01	3.97e-01	0.27200	2.65e-01	-6.03e-02	7.57e-02	6.86e-01
Synthesis of PIPs at the early endosome membrane	16	1.95e-01	3.98e-01	0.25900	2.41e-01	9.30e-02	9.47e-02	5.20e-01
Synthesis of IP3 and IP4 in the cytosol	26	1.97e-01	4.02e-01	0.20700	-1.08e-01	1.76e-01	3.40e-01	1.20e-01
G-protein beta:gamma signalling	31	2.01e-01	4.09e-01	0.18600	-1.21e-02	-1.85e-01	9.07e-01	7.43e-02
Inactivation of APC/C via direct inhibition of the APC/C complex	20	2.02e-01	4.12e-01	0.23000	-1.70e-02	-2.30e-01	8.95e-01	7.54e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	20	2.02e-01	4.12e-01	0.23000	-1.70e-02	-2.30e-01	8.95e-01	7.54e-02
APC/C-mediated degradation of cell cycle proteins	84	2.04e-01	4.13e-01	0.11200	2.63e-02	1.09e-01	6.78e-01	8.50e-02
Regulation of mitotic cell cycle	84	2.04e-01	4.13e-01	0.11200	2.63e-02	1.09e-01	6.78e-01	8.50e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	24	2.05e-01	4.14e-01	0.20700	-1.43e-01	-1.49e-01	2.24e-01	2.06e-01
HATs acetylate histones	84	2.05e-01	4.14e-01	0.11400	-9.92e-02	5.59e-02	1.16e-01	3.76e-01
Defects in cobalamin (B12) metabolism	14	2.05e-01	4.14e-01	0.27600	-2.70e-01	5.66e-02	7.98e-02	7.14e-01
Regulation of TLR by endogenous ligand	15	2.06e-01	4.15e-01	0.26100	-2.01e-01	-1.67e-01	1.78e-01	2.63e-01
Nuclear Envelope Breakdown	50	2.07e-01	4.16e-01	0.14700	7.32e-02	-1.27e-01	3.71e-01	1.19e-01
Metal ion SLC transporters	26	2.07e-01	4.16e-01	0.20400	1.78e-01	-9.84e-02	1.16e-01	3.85e-01
Defective B3GALTL causes Peters-plus syndrome (PpS)	36	2.07e-01	4.16e-01	0.17300	9.75e-02	-1.43e-01	3.12e-01	1.37e-01
Signaling by NOTCH2	29	2.08e-01	4.16e-01	0.19300	-1.20e-01	1.51e-01	2.63e-01	1.59e-01
Passive transport by Aquaporins	11	2.08e-01	4.17e-01	0.31300	-2.32e-01	2.10e-01	1.82e-01	2.29e-01
Adaptive Immune System	686	2.09e-01	4.17e-01	0.04020	-1.40e-02	3.77e-02	5.34e-01	9.40e-02
IRS-related events triggered by IGF1R	47	2.10e-01	4.19e-01	0.15000	1.47e-01	-2.80e-02	8.11e-02	7.40e-01
TNFR1-induced proapoptotic signaling	13	2.11e-01	4.19e-01	0.28600	-2.56e-01	1.27e-01	1.10e-01	4.26e-01
Processive synthesis on the C-strand of the telomere	18	2.11e-01	4.19e-01	0.24100	3.77e-02	-2.38e-01	7.82e-01	8.01e-02
PIP3 activates AKT signaling	265	2.11e-01	4.19e-01	0.06310	-2.83e-03	6.31e-02	9.37e-01	7.76e-02
Association of TriC/CCT with target proteins during biosynthesis	38	2.11e-01	4.20e-01	0.16600	-4.28e-02	1.61e-01	6.48e-01	8.63e-02
Cytosolic iron-sulfur cluster assembly	13	2.12e-01	4.20e-01	0.28100	5.31e-02	2.76e-01	7.40e-01	8.54e-02
Presynaptic depolarization and calcium channel opening	12	2.12e-01	4.20e-01	0.29400	2.78e-02	-2.93e-01	8.68e-01	7.87e-02
G1/S-Specific Transcription	29	2.13e-01	4.22e-01	0.19100	1.19e-01	-1.50e-01	2.69e-01	1.62e-01
RHO GTPases Activate NADPH Oxidases	23	2.14e-01	4.23e-01	0.20900	1.79e-01	1.08e-01	1.38e-01	3.72e-01
RHO GTPases Activate ROCKs	19	2.14e-01	4.23e-01	0.23000	-2.03e-01	-1.07e-01	1.25e-01	4.20e-01
FGFR2 mutant receptor activation	28	2.18e-01	4.30e-01	0.18800	1.13e-01	1.50e-01	3.01e-01	1.69e-01
Insulin receptor recycling	25	2.20e-01	4.33e-01	0.19800	1.68e-01	1.06e-01	1.47e-01	3.59e-01
FOXO-mediated transcription of cell cycle genes	16	2.22e-01	4.37e-01	0.24800	-1.10e-01	-2.22e-01	4.46e-01	1.25e-01
DNA methylation	15	2.22e-01	4.37e-01	0.25500	-1.16e-01	-2.28e-01	4.38e-01	1.27e-01
Ras activation upon Ca2+ influx through NMDA receptor	19	2.23e-01	4.37e-01	0.22800	4.38e-02	2.24e-01	7.41e-01	9.10e-02
ESR-mediated signaling	164	2.24e-01	4.38e-01	0.07920	7.24e-02	-3.23e-02	1.10e-01	4.76e-01
PIWI-interacting RNA (piRNA) biogenesis	25	2.24e-01	4.38e-01	0.19900	3.07e-02	1.96e-01	7.91e-01	8.91e-02
RNA Polymerase II Transcription Termination	63	2.25e-01	4.40e-01	0.12600	2.20e-02	-1.24e-01	7.63e-01	8.77e-02
Heme biosynthesis	13	2.27e-01	4.42e-01	0.27300	1.21e-01	2.44e-01	4.50e-01	1.27e-01
IRS-mediated signalling	44	2.28e-01	4.43e-01	0.15100	1.48e-01	-3.04e-02	9.04e-02	7.27e-01
Nucleotide salvage	22	2.29e-01	4.43e-01	0.21300	-4.42e-02	2.08e-01	7.20e-01	9.11e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat	44	2.29e-01	4.43e-01	0.15200	-1.04e-01	1.10e-01	2.32e-01	2.05e-01
HIV Transcription Elongation	44	2.29e-01	4.43e-01	0.15200	-1.04e-01	1.10e-01	2.32e-01	2.05e-01
Tat-mediated elongation of the HIV-1 transcript	44	2.29e-01	4.43e-01	0.15200	-1.04e-01	1.10e-01	2.32e-01	2.05e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	2.30e-01	4.45e-01	0.29900	-2.98e-01	1.02e-02	8.65e-02	9.53e-01
SHC1 events in EGFR signaling	14	2.32e-01	4.47e-01	0.26800	1.55e-01	-2.18e-01	3.16e-01	1.58e-01
HDMs demethylate histones	21	2.33e-01	4.48e-01	0.21400	-6.02e-02	-2.05e-01	6.33e-01	1.04e-01
Leading Strand Synthesis	13	2.34e-01	4.49e-01	0.27400	2.17e-02	-2.73e-01	8.92e-01	8.85e-02
Polymerase switching	13	2.34e-01	4.49e-01	0.27400	2.17e-02	-2.73e-01	8.92e-01	8.85e-02
Hyaluronan metabolism	17	2.34e-01	4.50e-01	0.24100	2.15e-01	-1.11e-01	1.26e-01	4.29e-01
RET signaling	39	2.35e-01	4.51e-01	0.15600	-3.06e-02	-1.53e-01	7.41e-01	9.73e-02
Phase II - Conjugation of compounds	78	2.35e-01	4.51e-01	0.11000	-8.27e-02	-7.22e-02	2.07e-01	2.70e-01
Signaling by ERBB2 in Cancer	24	2.36e-01	4.51e-01	0.20300	1.71e-01	-1.09e-01	1.46e-01	3.56e-01
TBC/RABGAPs	44	2.37e-01	4.51e-01	0.14700	2.95e-02	1.44e-01	7.35e-01	9.82e-02
O-glycosylation of TSR domain-containing proteins	37	2.37e-01	4.51e-01	0.16400	1.12e-01	-1.19e-01	2.37e-01	2.11e-01
Formation of HIV elongation complex in the absence of HIV Tat	46	2.37e-01	4.51e-01	0.14700	-8.86e-02	1.17e-01	2.98e-01	1.70e-01
Nucleobase biosynthesis	13	2.37e-01	4.51e-01	0.26900	1.22e-01	2.39e-01	4.45e-01	1.36e-01
PI3K Cascade	40	2.38e-01	4.52e-01	0.15500	1.54e-01	-1.87e-02	9.14e-02	8.38e-01
PKMTs methylate histone lysines	43	2.39e-01	4.53e-01	0.14700	-1.35e-01	-5.89e-02	1.25e-01	5.04e-01
COPII-mediated vesicle transport	61	2.39e-01	4.53e-01	0.12700	-9.98e-02	7.85e-02	1.78e-01	2.89e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	2.41e-01	4.55e-01	0.26400	-1.19e-01	2.35e-01	4.39e-01	1.28e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	2.41e-01	4.55e-01	0.26400	-1.19e-01	2.35e-01	4.39e-01	1.28e-01
Degradation of cysteine and homocysteine	11	2.42e-01	4.56e-01	0.29400	-2.92e-01	3.41e-02	9.32e-02	8.45e-01
Cellular hexose transport	19	2.42e-01	4.56e-01	0.22600	-1.22e-01	1.91e-01	3.57e-01	1.51e-01
Presynaptic function of Kainate receptors	20	2.42e-01	4.56e-01	0.21900	6.86e-02	-2.08e-01	5.96e-01	1.07e-01
Smooth Muscle Contraction	32	2.43e-01	4.56e-01	0.17300	-1.70e-01	3.27e-02	9.67e-02	7.49e-01
Adenylate cyclase activating pathway	10	2.44e-01	4.58e-01	0.30300	-2.64e-01	-1.48e-01	1.48e-01	4.16e-01
Lagging Strand Synthesis	19	2.44e-01	4.58e-01	0.22200	-1.92e-03	-2.22e-01	9.88e-01	9.34e-02
NOTCH1 Intracellular Domain Regulates Transcription	43	2.44e-01	4.58e-01	0.14800	-1.47e-01	-1.12e-02	9.50e-02	8.99e-01
Adenylate cyclase inhibitory pathway	14	2.45e-01	4.58e-01	0.25700	-2.44e-01	-8.10e-02	1.15e-01	6.00e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	13	2.47e-01	4.61e-01	0.26800	-3.25e-03	-2.67e-01	9.84e-01	9.50e-02
Transport of the SLBP Dependant Mature mRNA	35	2.48e-01	4.61e-01	0.16600	1.26e-01	-1.07e-01	1.98e-01	2.71e-01
PI3K events in ERBB4 signaling	10	2.48e-01	4.61e-01	0.30200	2.85e-01	1.00e-01	1.18e-01	5.84e-01
FGFR2 ligand binding and activation	15	2.48e-01	4.61e-01	0.24600	2.09e-01	1.30e-01	1.62e-01	3.85e-01
Activation of NMDA receptors and postsynaptic events	71	2.48e-01	4.61e-01	0.11500	-1.93e-02	1.13e-01	7.79e-01	9.83e-02
Metabolism of folate and pterines	17	2.49e-01	4.62e-01	0.23400	-2.34e-01	1.42e-02	9.56e-02	9.19e-01
Potential therapeutics for SARS	76	2.49e-01	4.62e-01	0.11200	-7.61e-02	8.24e-02	2.51e-01	2.14e-01
GABA synthesis, release, reuptake and degradation	18	2.50e-01	4.62e-01	0.22900	-9.04e-02	2.11e-01	5.07e-01	1.22e-01
TRAF3-dependent IRF activation pathway	12	2.50e-01	4.62e-01	0.28100	-1.16e-01	2.55e-01	4.86e-01	1.25e-01
Apoptotic cleavage of cell adhesion proteins	11	2.50e-01	4.62e-01	0.28600	-1.36e-01	-2.52e-01	4.35e-01	1.48e-01
Integration of energy metabolism	101	2.51e-01	4.63e-01	0.09440	-7.63e-02	-5.56e-02	1.85e-01	3.35e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	29	2.52e-01	4.63e-01	0.17900	-1.77e-01	2.22e-02	9.85e-02	8.36e-01
SARS-CoV Infections	138	2.52e-01	4.63e-01	0.08290	-4.30e-02	7.09e-02	3.83e-01	1.51e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	2.52e-01	4.63e-01	0.27300	1.49e-01	2.29e-01	3.72e-01	1.70e-01
Regulation of insulin secretion	73	2.53e-01	4.63e-01	0.11200	-1.53e-02	-1.11e-01	8.21e-01	1.02e-01
GP1b-IX-V activation signalling	10	2.54e-01	4.64e-01	0.30100	-2.96e-01	-5.34e-02	1.05e-01	7.70e-01
PI3K events in ERBB2 signaling	16	2.54e-01	4.64e-01	0.24100	2.31e-01	-6.81e-02	1.09e-01	6.37e-01
Protein methylation	14	2.54e-01	4.64e-01	0.25400	5.09e-02	2.49e-01	7.42e-01	1.07e-01
Phosphorylation of the APC/C	19	2.54e-01	4.64e-01	0.21700	-7.56e-02	-2.04e-01	5.68e-01	1.25e-01
ECM proteoglycans	53	2.56e-01	4.67e-01	0.13300	1.17e-01	-6.33e-02	1.42e-01	4.26e-01
mRNA Capping	27	2.57e-01	4.67e-01	0.18100	7.82e-02	1.64e-01	4.82e-01	1.41e-01
TNFR1-induced NFkappaB signaling pathway	26	2.58e-01	4.68e-01	0.18900	-1.11e-01	1.53e-01	3.28e-01	1.76e-01
Transport of the SLBP independent Mature mRNA	34	2.61e-01	4.73e-01	0.16500	1.28e-01	-1.04e-01	1.97e-01	2.94e-01
Translation initiation complex formation	49	2.61e-01	4.73e-01	0.13300	1.05e-01	8.27e-02	2.05e-01	3.16e-01
RNA Polymerase II Transcription	1082	2.61e-01	4.73e-01	0.02940	-1.11e-02	-2.72e-02	5.39e-01	1.33e-01
NCAM signaling for neurite out-growth	52	2.63e-01	4.75e-01	0.13100	1.26e-02	-1.31e-01	8.76e-01	1.03e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	2.64e-01	4.76e-01	0.14800	-1.47e-01	1.81e-02	1.04e-01	8.41e-01
Signaling by RAS mutants	41	2.64e-01	4.76e-01	0.14800	-1.47e-01	1.81e-02	1.04e-01	8.41e-01
Signaling by moderate kinase activity BRAF mutants	41	2.64e-01	4.76e-01	0.14800	-1.47e-01	1.81e-02	1.04e-01	8.41e-01
Signaling downstream of RAS mutants	41	2.64e-01	4.76e-01	0.14800	-1.47e-01	1.81e-02	1.04e-01	8.41e-01
Interleukin-37 signaling	19	2.65e-01	4.76e-01	0.21300	1.20e-01	1.76e-01	3.66e-01	1.83e-01
Ribosomal scanning and start codon recognition	50	2.66e-01	4.78e-01	0.13100	1.10e-01	7.10e-02	1.77e-01	3.85e-01
PI-3K cascade:FGFR2	20	2.67e-01	4.80e-01	0.20800	2.00e-01	5.75e-02	1.22e-01	6.56e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	17	2.69e-01	4.81e-01	0.22900	7.87e-02	-2.15e-01	5.74e-01	1.25e-01
Amino acid transport across the plasma membrane	32	2.69e-01	4.81e-01	0.16700	4.39e-02	-1.61e-01	6.68e-01	1.15e-01
VEGFA-VEGFR2 Pathway	91	2.69e-01	4.81e-01	0.09760	-2.27e-02	-9.50e-02	7.08e-01	1.18e-01
Fc epsilon receptor (FCERI) signaling	152	2.71e-01	4.84e-01	0.07500	6.43e-02	3.86e-02	1.72e-01	4.12e-01
Repression of WNT target genes	14	2.72e-01	4.85e-01	0.25200	-2.20e-01	1.24e-01	1.55e-01	4.23e-01
Adherens junctions interactions	31	2.73e-01	4.85e-01	0.16500	-1.47e-01	-7.48e-02	1.55e-01	4.71e-01
Uptake and function of anthrax toxins	10	2.73e-01	4.85e-01	0.29800	-1.43e-01	2.61e-01	4.34e-01	1.52e-01
ERK/MAPK targets	21	2.73e-01	4.85e-01	0.20500	-1.96e-01	5.75e-02	1.19e-01	6.48e-01
Activation of Matrix Metalloproteinases	28	2.73e-01	4.85e-01	0.17600	8.95e-04	-1.76e-01	9.93e-01	1.07e-01
Downstream signaling of activated FGFR2	27	2.74e-01	4.85e-01	0.17900	1.78e-01	-1.94e-02	1.09e-01	8.61e-01
Effects of PIP2 hydrolysis	26	2.74e-01	4.85e-01	0.18000	-1.39e-01	-1.13e-01	2.18e-01	3.17e-01
Insulin receptor signalling cascade	50	2.75e-01	4.85e-01	0.13300	1.21e-01	-5.47e-02	1.39e-01	5.04e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	99	2.75e-01	4.85e-01	0.09390	1.58e-02	-9.25e-02	7.86e-01	1.12e-01
RAB GEFs exchange GTP for GDP on RABs	85	2.76e-01	4.85e-01	0.10000	2.18e-02	9.77e-02	7.28e-01	1.20e-01
Signal transduction by L1	21	2.76e-01	4.85e-01	0.20400	-1.92e-01	6.83e-02	1.27e-01	5.88e-01
Assembly Of The HIV Virion	15	2.78e-01	4.90e-01	0.24100	-2.11e-01	1.16e-01	1.56e-01	4.35e-01
SUMOylation of DNA replication proteins	44	2.79e-01	4.91e-01	0.14100	6.34e-02	-1.26e-01	4.67e-01	1.49e-01
NOTCH3 Intracellular Domain Regulates Transcription	22	2.84e-01	4.98e-01	0.19300	-1.55e-01	-1.15e-01	2.08e-01	3.52e-01
Platelet activation, signaling and aggregation	251	2.84e-01	4.98e-01	0.05740	-3.28e-02	-4.72e-02	3.72e-01	1.99e-01
Mucopolysaccharidoses	11	2.86e-01	5.00e-01	0.27200	-2.36e-01	-1.36e-01	1.76e-01	4.34e-01
Activation of GABAB receptors	42	2.87e-01	5.00e-01	0.14000	-4.77e-02	-1.31e-01	5.92e-01	1.41e-01
GABA B receptor activation	42	2.87e-01	5.00e-01	0.14000	-4.77e-02	-1.31e-01	5.92e-01	1.41e-01
Reversible hydration of carbon dioxide	12	2.87e-01	5.00e-01	0.26200	-2.53e-01	-6.65e-02	1.29e-01	6.90e-01
EPHA-mediated growth cone collapse	15	2.88e-01	5.01e-01	0.23200	-1.42e-01	-1.83e-01	3.40e-01	2.19e-01
ADP signalling through P2Y purinoceptor 12	21	2.88e-01	5.01e-01	0.20100	8.63e-02	-1.82e-01	4.93e-01	1.50e-01
STING mediated induction of host immune responses	16	2.89e-01	5.02e-01	0.23000	-1.02e-01	2.06e-01	4.79e-01	1.53e-01
WNT5A-dependent internalization of FZD4	15	2.89e-01	5.02e-01	0.23100	1.67e-01	1.61e-01	2.64e-01	2.81e-01
Signaling by Erythropoietin	25	2.93e-01	5.07e-01	0.18100	1.09e-02	-1.81e-01	9.25e-01	1.17e-01
Intracellular signaling by second messengers	302	2.93e-01	5.07e-01	0.05310	-2.17e-02	4.84e-02	5.17e-01	1.49e-01
Formation of the ternary complex, and subsequently, the 43S complex	44	2.93e-01	5.07e-01	0.13500	1.22e-01	5.82e-02	1.63e-01	5.04e-01
Nuclear Events (kinase and transcription factor activation)	57	2.94e-01	5.08e-01	0.12100	-1.13e-01	4.40e-02	1.41e-01	5.66e-01
FGFRL1 modulation of FGFR1 signaling	11	2.96e-01	5.10e-01	0.27600	2.21e-01	-1.65e-01	2.05e-01	3.43e-01
Regulation of gene expression in beta cells	19	2.96e-01	5.10e-01	0.20700	-2.07e-01	-1.21e-05	1.19e-01	1.00e+00
mRNA decay by 5' to 3' exoribonuclease	15	2.98e-01	5.13e-01	0.23000	-2.18e-01	-7.23e-02	1.43e-01	6.28e-01
InlB-mediated entry of Listeria monocytogenes into host cell	14	2.98e-01	5.13e-01	0.24400	-1.64e-01	1.80e-01	2.88e-01	2.43e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	50	3.02e-01	5.18e-01	0.12500	8.82e-02	8.82e-02	2.81e-01	2.81e-01
Ion homeostasis	47	3.02e-01	5.18e-01	0.13100	-9.93e-03	1.30e-01	9.06e-01	1.22e-01
Metabolism of vitamins and cofactors	179	3.03e-01	5.19e-01	0.06790	-5.87e-02	3.41e-02	1.76e-01	4.31e-01
Cytokine Signaling in Immune system	784	3.04e-01	5.20e-01	0.03300	-2.26e-02	2.41e-02	2.83e-01	2.54e-01
TP53 Regulates Transcription of DNA Repair Genes	61	3.04e-01	5.20e-01	0.11600	-9.52e-02	6.58e-02	1.98e-01	3.74e-01
Signaling by FGFR3 fusions in cancer	10	3.05e-01	5.20e-01	0.28500	1.63e-01	-2.34e-01	3.72e-01	2.00e-01
Creatine metabolism	10	3.05e-01	5.20e-01	0.28500	-1.34e-01	2.51e-01	4.62e-01	1.69e-01
RNA Polymerase I Promoter Escape	38	3.06e-01	5.20e-01	0.14300	7.24e-02	1.23e-01	4.40e-01	1.90e-01
Signaling by high-kinase activity BRAF mutants	34	3.07e-01	5.21e-01	0.15000	-1.12e-01	-9.95e-02	2.56e-01	3.15e-01
The canonical retinoid cycle in rods (twilight vision)	23	3.09e-01	5.25e-01	0.18700	9.76e-02	-1.60e-01	4.18e-01	1.85e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	22	3.10e-01	5.26e-01	0.18900	-1.87e-01	2.90e-02	1.29e-01	8.14e-01
GABA receptor activation	56	3.10e-01	5.26e-01	0.11800	-1.59e-02	-1.17e-01	8.37e-01	1.31e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	21	3.12e-01	5.29e-01	0.19400	-7.33e-02	1.80e-01	5.61e-01	1.54e-01
GRB2 events in EGFR signaling	13	3.13e-01	5.29e-01	0.24700	1.01e-01	-2.25e-01	5.26e-01	1.60e-01
MAPK family signaling cascades	306	3.14e-01	5.31e-01	0.05090	-8.09e-03	5.02e-02	8.08e-01	1.31e-01
SUMOylation of chromatin organization proteins	56	3.15e-01	5.31e-01	0.11900	8.94e-02	-7.89e-02	2.48e-01	3.07e-01
Regulation of gene expression by Hypoxia-inducible Factor	11	3.17e-01	5.33e-01	0.26500	-2.62e-01	4.23e-02	1.33e-01	8.08e-01
Response of Mtb to phagocytosis	21	3.17e-01	5.33e-01	0.19300	-7.16e-02	1.79e-01	5.70e-01	1.55e-01
Nuclear import of Rev protein	33	3.19e-01	5.36e-01	0.15400	1.25e-01	-8.98e-02	2.13e-01	3.72e-01
Glucagon-type ligand receptors	29	3.19e-01	5.36e-01	0.16400	6.84e-02	-1.49e-01	5.24e-01	1.65e-01
MECP2 regulates neuronal receptors and channels	16	3.20e-01	5.36e-01	0.22100	1.87e-01	-1.17e-01	1.95e-01	4.16e-01
NRIF signals cell death from the nucleus	15	3.20e-01	5.36e-01	0.22800	-1.75e-01	1.46e-01	2.40e-01	3.27e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	19	3.23e-01	5.38e-01	0.20200	9.68e-02	-1.77e-01	4.65e-01	1.82e-01
Regulation of TNFR1 signaling	34	3.23e-01	5.38e-01	0.15100	-8.07e-02	1.28e-01	4.15e-01	1.98e-01
SHC-mediated cascade:FGFR2	20	3.23e-01	5.38e-01	0.19300	1.84e-01	5.81e-02	1.55e-01	6.53e-01
p75NTR recruits signalling complexes	12	3.23e-01	5.38e-01	0.25400	-1.66e-01	1.92e-01	3.18e-01	2.49e-01
RUNX2 regulates osteoblast differentiation	24	3.24e-01	5.39e-01	0.17600	1.72e-01	3.84e-02	1.45e-01	7.45e-01
rRNA modification in the nucleus and cytosol	57	3.24e-01	5.39e-01	0.11400	4.49e-02	1.05e-01	5.58e-01	1.72e-01
Vitamin B5 (pantothenate) metabolism	15	3.25e-01	5.39e-01	0.22700	1.80e-01	-1.39e-01	2.29e-01	3.53e-01
G beta:gamma signalling through PLC beta	19	3.25e-01	5.39e-01	0.20100	9.65e-02	-1.76e-01	4.67e-01	1.83e-01
AKT phosphorylates targets in the cytosol	14	3.26e-01	5.40e-01	0.23400	-2.09e-01	1.06e-01	1.77e-01	4.93e-01
Serotonin Neurotransmitter Release Cycle	18	3.26e-01	5.40e-01	0.20200	6.79e-02	1.90e-01	6.18e-01	1.63e-01
MAPK targets/ Nuclear events mediated by MAP kinases	30	3.27e-01	5.40e-01	0.16000	-8.10e-02	1.38e-01	4.43e-01	1.92e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	26	3.27e-01	5.40e-01	0.16800	-1.60e-01	-5.00e-02	1.57e-01	6.59e-01
Signaling by FGFR in disease	57	3.29e-01	5.41e-01	0.11300	8.51e-02	7.38e-02	2.67e-01	3.35e-01
Activation of G protein gated Potassium channels	28	3.29e-01	5.41e-01	0.16400	5.03e-02	-1.56e-01	6.45e-01	1.53e-01
G protein gated Potassium channels	28	3.29e-01	5.41e-01	0.16400	5.03e-02	-1.56e-01	6.45e-01	1.53e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	28	3.29e-01	5.41e-01	0.16400	5.03e-02	-1.56e-01	6.45e-01	1.53e-01
Apoptosis induced DNA fragmentation	12	3.30e-01	5.41e-01	0.24700	-5.04e-02	-2.42e-01	7.62e-01	1.47e-01
Interactions of Rev with host cellular proteins	36	3.30e-01	5.42e-01	0.14500	1.28e-01	-6.82e-02	1.84e-01	4.79e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	23	3.31e-01	5.43e-01	0.18100	1.57e-01	-9.07e-02	1.93e-01	4.51e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	3.32e-01	5.43e-01	0.25500	1.76e-01	1.85e-01	3.13e-01	2.89e-01
Killing mechanisms	12	3.33e-01	5.44e-01	0.24500	2.30e-01	8.44e-02	1.68e-01	6.13e-01
WNT5:FZD7-mediated leishmania damping	12	3.33e-01	5.44e-01	0.24500	2.30e-01	8.44e-02	1.68e-01	6.13e-01
Metabolism of water-soluble vitamins and cofactors	119	3.35e-01	5.46e-01	0.07970	-6.14e-02	5.08e-02	2.48e-01	3.39e-01
SUMOylation of ubiquitinylation proteins	38	3.36e-01	5.46e-01	0.14000	9.96e-02	-9.90e-02	2.88e-01	2.91e-01
Interleukin-2 signaling	12	3.37e-01	5.46e-01	0.24500	-2.41e-01	-4.21e-02	1.48e-01	8.01e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	3.37e-01	5.46e-01	0.25900	-5.84e-02	2.52e-01	7.37e-01	1.48e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	31	3.37e-01	5.46e-01	0.15500	9.97e-02	-1.19e-01	3.37e-01	2.51e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	31	3.37e-01	5.46e-01	0.15500	9.97e-02	-1.19e-01	3.37e-01	2.51e-01
Signaling by Non-Receptor Tyrosine Kinases	53	3.40e-01	5.49e-01	0.11700	1.82e-02	-1.16e-01	8.19e-01	1.45e-01
Signaling by PTK6	53	3.40e-01	5.49e-01	0.11700	1.82e-02	-1.16e-01	8.19e-01	1.45e-01
APC-Cdc20 mediated degradation of Nek2A	24	3.41e-01	5.51e-01	0.17300	4.85e-03	-1.73e-01	9.67e-01	1.42e-01
Transmission across Chemical Synapses	233	3.42e-01	5.51e-01	0.05580	-5.58e-02	1.27e-03	1.43e-01	9.73e-01
Formation of the Early Elongation Complex	31	3.42e-01	5.51e-01	0.15200	2.32e-03	1.52e-01	9.82e-01	1.43e-01
Formation of the HIV-1 Early Elongation Complex	31	3.42e-01	5.51e-01	0.15200	2.32e-03	1.52e-01	9.82e-01	1.43e-01
Activated point mutants of FGFR2	14	3.45e-01	5.55e-01	0.22300	2.03e-01	9.09e-02	1.88e-01	5.56e-01
Negative regulation of the PI3K/AKT network	106	3.45e-01	5.55e-01	0.08240	1.50e-02	-8.11e-02	7.90e-01	1.50e-01
PKA-mediated phosphorylation of CREB	18	3.46e-01	5.55e-01	0.20000	-1.89e-01	6.51e-02	1.65e-01	6.32e-01
Acyl chain remodelling of PC	26	3.48e-01	5.59e-01	0.16500	-2.74e-02	1.63e-01	8.09e-01	1.50e-01
SUMOylation of intracellular receptors	30	3.49e-01	5.59e-01	0.15100	-1.02e-01	-1.11e-01	3.34e-01	2.92e-01
Deadenylation-dependent mRNA decay	51	3.50e-01	5.60e-01	0.11600	-6.23e-02	-9.75e-02	4.42e-01	2.28e-01
Norepinephrine Neurotransmitter Release Cycle	18	3.50e-01	5.60e-01	0.19600	4.20e-02	1.91e-01	7.58e-01	1.60e-01
HIV Life Cycle	142	3.51e-01	5.60e-01	0.07010	9.38e-03	6.95e-02	8.47e-01	1.53e-01
NEP/NS2 Interacts with the Cellular Export Machinery	31	3.52e-01	5.61e-01	0.15200	1.07e-01	-1.08e-01	3.03e-01	2.97e-01
Signaling by RAF1 mutants	38	3.53e-01	5.62e-01	0.13500	-1.35e-01	-2.98e-03	1.49e-01	9.75e-01
Regulation of IFNG signaling	14	3.55e-01	5.64e-01	0.22200	2.21e-01	1.62e-02	1.52e-01	9.16e-01
Interleukin-15 signaling	14	3.55e-01	5.64e-01	0.22500	-9.87e-02	2.02e-01	5.23e-01	1.91e-01
Acyl chain remodelling of PI	16	3.55e-01	5.64e-01	0.20500	1.25e-01	1.62e-01	3.86e-01	2.62e-01
DAG and IP3 signaling	38	3.56e-01	5.64e-01	0.13400	-1.26e-01	-4.48e-02	1.80e-01	6.33e-01
Signaling by FGFR2 IIIa TM	17	3.56e-01	5.64e-01	0.20100	2.17e-03	2.01e-01	9.88e-01	1.51e-01
tRNA processing in the nucleus	57	3.57e-01	5.65e-01	0.11000	1.10e-01	2.86e-03	1.52e-01	9.70e-01
Tryptophan catabolism	14	3.62e-01	5.72e-01	0.21700	-1.36e-01	-1.69e-01	3.79e-01	2.73e-01
Regulation of KIT signaling	16	3.62e-01	5.72e-01	0.20600	-6.42e-03	-2.05e-01	9.65e-01	1.55e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	3.63e-01	5.73e-01	0.25100	-1.10e-01	2.25e-01	5.28e-01	1.96e-01
SUMOylation of DNA methylation proteins	16	3.66e-01	5.77e-01	0.20700	-6.91e-02	1.95e-01	6.32e-01	1.78e-01
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	10	3.66e-01	5.77e-01	0.26100	7.61e-02	-2.49e-01	6.77e-01	1.72e-01
RHO GTPases activate PKNs	44	3.67e-01	5.77e-01	0.12200	-3.49e-02	-1.17e-01	6.89e-01	1.78e-01
Regulation of PTEN gene transcription	58	3.69e-01	5.80e-01	0.10900	-6.25e-02	8.88e-02	4.10e-01	2.42e-01
G-protein mediated events	51	3.69e-01	5.80e-01	0.11300	-1.04e-01	-4.45e-02	1.99e-01	5.83e-01
Nuclear Pore Complex (NPC) Disassembly	34	3.70e-01	5.80e-01	0.14100	5.41e-02	-1.30e-01	5.85e-01	1.88e-01
Signaling by FGFR4 in disease	11	3.71e-01	5.81e-01	0.24500	-5.40e-03	-2.45e-01	9.75e-01	1.60e-01
RNA Polymerase I Promoter Clearance	56	3.72e-01	5.82e-01	0.10900	3.03e-03	1.08e-01	9.69e-01	1.60e-01
RNA Polymerase I Transcription	56	3.72e-01	5.82e-01	0.10900	3.03e-03	1.08e-01	9.69e-01	1.60e-01
Epigenetic regulation of gene expression	94	3.73e-01	5.82e-01	0.08470	-7.82e-02	3.25e-02	1.90e-01	5.86e-01
p75NTR signals via NF-kB	14	3.74e-01	5.82e-01	0.22000	-1.76e-01	1.31e-01	2.54e-01	3.96e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27	3.75e-01	5.83e-01	0.15500	-1.50e-01	-3.64e-02	1.76e-01	7.43e-01
GPVI-mediated activation cascade	32	3.75e-01	5.83e-01	0.14400	4.43e-02	-1.37e-01	6.64e-01	1.79e-01
Late Phase of HIV Life Cycle	130	3.76e-01	5.83e-01	0.07080	1.02e-02	7.01e-02	8.40e-01	1.68e-01
Transcriptional Regulation by MECP2	56	3.76e-01	5.83e-01	0.10800	8.56e-03	1.07e-01	9.12e-01	1.64e-01
SHC1 events in ERBB2 signaling	22	3.77e-01	5.85e-01	0.17300	1.63e-01	-5.93e-02	1.86e-01	6.30e-01
IRF3-mediated induction of type I IFN	13	3.78e-01	5.85e-01	0.22500	-7.07e-02	2.14e-01	6.59e-01	1.82e-01
IRAK4 deficiency (TLR2/4)	10	3.78e-01	5.85e-01	0.25700	9.22e-02	-2.40e-01	6.14e-01	1.89e-01
Regulation of localization of FOXO transcription factors	11	3.79e-01	5.85e-01	0.24400	-5.10e-02	2.39e-01	7.70e-01	1.71e-01
Glycerophospholipid biosynthesis	123	3.80e-01	5.85e-01	0.07370	-5.71e-02	4.66e-02	2.74e-01	3.72e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	3.80e-01	5.85e-01	0.22100	-6.98e-02	-2.10e-01	6.63e-01	1.91e-01
Defective EXT2 causes exostoses 2	13	3.80e-01	5.85e-01	0.22100	-6.98e-02	-2.10e-01	6.63e-01	1.91e-01
Signaling by VEGF	100	3.81e-01	5.85e-01	0.07930	-4.79e-02	-6.32e-02	4.08e-01	2.75e-01
Integrin cell surface interactions	60	3.81e-01	5.85e-01	0.10300	-2.26e-02	-1.01e-01	7.62e-01	1.78e-01
ADP signalling through P2Y purinoceptor 1	23	3.81e-01	5.85e-01	0.17000	1.10e-01	-1.29e-01	3.60e-01	2.84e-01
Purine salvage	13	3.82e-01	5.85e-01	0.22000	8.95e-02	2.01e-01	5.76e-01	2.11e-01
Neurexins and neuroligins	54	3.82e-01	5.85e-01	0.11100	6.96e-02	-8.60e-02	3.77e-01	2.74e-01
Biosynthesis of DHA-derived SPMs	15	3.83e-01	5.85e-01	0.21000	1.57e-01	-1.39e-01	2.94e-01	3.50e-01
Long-term potentiation	22	3.83e-01	5.85e-01	0.17200	-6.44e-02	1.60e-01	6.01e-01	1.94e-01
MicroRNA (miRNA) biogenesis	24	3.83e-01	5.85e-01	0.16400	-1.21e-02	1.63e-01	9.18e-01	1.66e-01
Cilium Assembly	179	3.84e-01	5.86e-01	0.06000	3.07e-05	-6.00e-02	9.99e-01	1.67e-01
Glucagon signaling in metabolic regulation	30	3.85e-01	5.86e-01	0.14400	-1.34e-01	-5.28e-02	2.03e-01	6.17e-01
M Phase	346	3.85e-01	5.86e-01	0.04370	4.18e-02	-1.26e-02	1.82e-01	6.87e-01
Activated NTRK2 signals through FRS2 and FRS3	11	3.86e-01	5.87e-01	0.23900	2.34e-01	4.96e-02	1.80e-01	7.76e-01
Nuclear signaling by ERBB4	29	3.89e-01	5.91e-01	0.14900	-1.31e-01	7.25e-02	2.24e-01	4.99e-01
EPH-Ephrin signaling	90	3.90e-01	5.93e-01	0.08270	-3.54e-02	-7.48e-02	5.61e-01	2.21e-01
Telomere Extension By Telomerase	23	3.92e-01	5.94e-01	0.16500	6.48e-03	-1.65e-01	9.57e-01	1.71e-01
Cohesin Loading onto Chromatin	10	3.92e-01	5.94e-01	0.24800	-7.65e-02	-2.35e-01	6.75e-01	1.97e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	24	3.96e-01	5.97e-01	0.16000	3.18e-02	1.56e-01	7.88e-01	1.85e-01
SUMOylation	163	3.96e-01	5.97e-01	0.06200	5.15e-03	-6.18e-02	9.10e-01	1.74e-01
Interactions of Vpr with host cellular proteins	34	3.96e-01	5.97e-01	0.13600	1.20e-01	-6.54e-02	2.27e-01	5.10e-01
Na+/Cl- dependent neurotransmitter transporters	17	3.96e-01	5.97e-01	0.18900	-5.88e-02	-1.79e-01	6.75e-01	2.00e-01
G1/S Transition	127	3.97e-01	5.97e-01	0.06930	6.56e-02	2.23e-02	2.02e-01	6.64e-01
HDACs deacetylate histones	39	3.97e-01	5.98e-01	0.12400	-8.13e-02	-9.36e-02	3.80e-01	3.12e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	68	3.98e-01	5.99e-01	0.09640	-8.23e-02	5.02e-02	2.41e-01	4.74e-01
Gene expression (Transcription)	1214	3.99e-01	5.99e-01	0.02300	-1.27e-02	-1.92e-02	4.60e-01	2.64e-01
Signaling by ERBB2 KD Mutants	23	4.00e-01	6.01e-01	0.16500	1.47e-01	-7.51e-02	2.23e-01	5.33e-01
G beta:gamma signalling through PI3Kgamma	24	4.01e-01	6.01e-01	0.16100	7.42e-02	-1.43e-01	5.29e-01	2.24e-01
The role of Nef in HIV-1 replication and disease pathogenesis	27	4.04e-01	6.04e-01	0.15100	-1.38e-01	6.16e-02	2.14e-01	5.79e-01
Unblocking of NMDA receptors, glutamate binding and activation	20	4.05e-01	6.06e-01	0.17300	7.39e-03	1.73e-01	9.54e-01	1.80e-01
Separation of Sister Chromatids	165	4.06e-01	6.06e-01	0.06050	6.04e-02	3.54e-03	1.81e-01	9.37e-01
Organic anion transporters	10	4.06e-01	6.06e-01	0.24700	-7.05e-02	2.37e-01	7.00e-01	1.95e-01
Hyaluronan uptake and degradation	12	4.06e-01	6.06e-01	0.22100	1.76e-01	1.33e-01	2.91e-01	4.25e-01
CD209 (DC-SIGN) signaling	19	4.07e-01	6.06e-01	0.17600	-6.96e-02	-1.62e-01	5.99e-01	2.23e-01
SHC1 events in ERBB4 signaling	14	4.09e-01	6.08e-01	0.20500	1.97e-01	5.65e-02	2.02e-01	7.14e-01
RORA activates gene expression	18	4.09e-01	6.08e-01	0.18000	-1.43e-01	-1.08e-01	2.93e-01	4.27e-01
Heparan sulfate/heparin (HS-GAG) metabolism	51	4.10e-01	6.09e-01	0.10700	-6.99e-02	-8.04e-02	3.88e-01	3.21e-01
Inwardly rectifying K+ channels	33	4.11e-01	6.09e-01	0.13500	3.57e-02	-1.30e-01	7.22e-01	1.95e-01
Signaling by BMP	26	4.16e-01	6.16e-01	0.14800	1.03e-01	1.06e-01	3.62e-01	3.50e-01
Beta defensins	10	4.16e-01	6.16e-01	0.23800	-1.82e-01	-1.54e-01	3.20e-01	3.98e-01
Arachidonic acid metabolism	51	4.17e-01	6.17e-01	0.10800	5.13e-02	-9.54e-02	5.26e-01	2.38e-01
Suppression of phagosomal maturation	12	4.18e-01	6.17e-01	0.22300	-1.29e-01	1.82e-01	4.39e-01	2.75e-01
GAB1 signalosome	17	4.19e-01	6.19e-01	0.18700	1.04e-01	-1.56e-01	4.60e-01	2.66e-01
Costimulation by the CD28 family	64	4.23e-01	6.24e-01	0.09570	-8.83e-02	3.70e-02	2.22e-01	6.09e-01
MET activates RAP1 and RAC1	11	4.24e-01	6.25e-01	0.22700	-2.34e-02	-2.26e-01	8.93e-01	1.94e-01
Vpr-mediated nuclear import of PICs	32	4.25e-01	6.26e-01	0.13500	8.00e-02	-1.09e-01	4.34e-01	2.85e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	35	4.27e-01	6.27e-01	0.12700	-2.04e-02	-1.25e-01	8.35e-01	2.00e-01
Diseases of mitotic cell cycle	35	4.27e-01	6.27e-01	0.12700	-2.04e-02	-1.25e-01	8.35e-01	2.00e-01
Growth hormone receptor signaling	21	4.28e-01	6.27e-01	0.16500	-1.42e-02	1.64e-01	9.10e-01	1.93e-01
Signaling by PDGF	50	4.28e-01	6.27e-01	0.10500	-4.05e-02	-9.73e-02	6.21e-01	2.34e-01
Removal of the Flap Intermediate from the C-strand	16	4.29e-01	6.27e-01	0.18900	3.16e-02	-1.86e-01	8.27e-01	1.97e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	12	4.29e-01	6.27e-01	0.21400	-1.52e-01	-1.50e-01	3.61e-01	3.68e-01
Rev-mediated nuclear export of HIV RNA	34	4.29e-01	6.27e-01	0.13000	1.18e-01	-5.48e-02	2.33e-01	5.81e-01
Digestion and absorption	21	4.30e-01	6.27e-01	0.16300	-4.13e-02	-1.57e-01	7.43e-01	2.12e-01
Nicotinamide salvaging	19	4.31e-01	6.28e-01	0.17000	7.12e-02	1.54e-01	5.91e-01	2.44e-01
SUMOylation of SUMOylation proteins	34	4.31e-01	6.28e-01	0.13000	7.74e-02	-1.05e-01	4.35e-01	2.90e-01
Signaling by ERBB2	47	4.33e-01	6.30e-01	0.11000	1.07e-01	-2.47e-02	2.05e-01	7.69e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	103	4.36e-01	6.33e-01	0.07430	6.77e-02	-3.07e-02	2.35e-01	5.91e-01
SLC-mediated transmembrane transport	235	4.37e-01	6.34e-01	0.04950	2.76e-02	-4.10e-02	4.66e-01	2.79e-01
Endogenous sterols	24	4.38e-01	6.35e-01	0.15400	9.81e-02	-1.18e-01	4.06e-01	3.16e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	30	4.38e-01	6.35e-01	0.13700	1.26e-01	-5.35e-02	2.32e-01	6.12e-01
Signaling by FGFR1	44	4.39e-01	6.35e-01	0.11300	7.48e-02	-8.52e-02	3.91e-01	3.28e-01
Transcriptional Regulation by TP53	341	4.39e-01	6.35e-01	0.04090	-1.43e-02	3.83e-02	6.52e-01	2.25e-01
Post-chaperonin tubulin folding pathway	18	4.40e-01	6.35e-01	0.17600	1.71e-01	-4.09e-02	2.10e-01	7.64e-01
FGFR2c ligand binding and activation	11	4.40e-01	6.35e-01	0.22100	2.08e-01	7.62e-02	2.33e-01	6.62e-01
Downstream signal transduction	29	4.41e-01	6.36e-01	0.13900	-1.07e-01	8.87e-02	3.17e-01	4.08e-01
APC/C:Cdc20 mediated degradation of Cyclin B	22	4.42e-01	6.36e-01	0.15500	-7.45e-02	-1.36e-01	5.45e-01	2.68e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	4.42e-01	6.36e-01	0.15800	-3.35e-02	1.55e-01	7.86e-01	2.09e-01
Circadian Clock	68	4.47e-01	6.43e-01	0.09000	-8.22e-02	3.67e-02	2.41e-01	6.01e-01
Signaling by FGFR	74	4.48e-01	6.43e-01	0.08650	5.73e-02	-6.48e-02	3.94e-01	3.36e-01
G2/M Checkpoints	133	4.48e-01	6.43e-01	0.06460	5.34e-02	-3.63e-02	2.88e-01	4.70e-01
G alpha (z) signalling events	47	4.51e-01	6.47e-01	0.10500	-5.80e-02	-8.75e-02	4.91e-01	3.00e-01
FRS-mediated FGFR2 signaling	22	4.52e-01	6.47e-01	0.15400	1.50e-01	3.49e-02	2.23e-01	7.77e-01
TICAM1, RIP1-mediated IKK complex recruitment	16	4.52e-01	6.47e-01	0.18000	1.73e-01	4.98e-02	2.30e-01	7.30e-01
G-protein activation	27	4.53e-01	6.47e-01	0.14200	1.18e-01	-7.94e-02	2.90e-01	4.75e-01
Spry regulation of FGF signaling	14	4.57e-01	6.52e-01	0.19600	-1.59e-01	1.15e-01	3.03e-01	4.58e-01
MET receptor recycling	10	4.57e-01	6.52e-01	0.22500	1.33e-01	1.82e-01	4.68e-01	3.19e-01
Downstream signaling of activated FGFR4	24	4.58e-01	6.52e-01	0.14900	1.41e-01	-4.76e-02	2.32e-01	6.87e-01
Signaling by NTRK1 (TRKA)	110	4.58e-01	6.52e-01	0.07000	-4.94e-02	4.96e-02	3.71e-01	3.69e-01
Metalloprotease DUBs	18	4.59e-01	6.52e-01	0.16800	1.04e-01	1.32e-01	4.46e-01	3.34e-01
Diseases associated with N-glycosylation of proteins	16	4.59e-01	6.52e-01	0.18300	1.41e-01	-1.16e-01	3.29e-01	4.20e-01
Transcriptional Regulation by E2F6	32	4.61e-01	6.54e-01	0.12800	3.30e-02	-1.24e-01	7.47e-01	2.26e-01
Frs2-mediated activation	12	4.62e-01	6.55e-01	0.21000	-1.85e-01	9.85e-02	2.67e-01	5.55e-01
SUMO E3 ligases SUMOylate target proteins	157	4.63e-01	6.56e-01	0.05740	9.33e-04	-5.74e-02	9.84e-01	2.15e-01
Ephrin signaling	19	4.64e-01	6.56e-01	0.16200	-1.12e-01	-1.17e-01	3.98e-01	3.78e-01
Nephrin family interactions	21	4.68e-01	6.61e-01	0.15600	1.55e-01	-1.85e-02	2.20e-01	8.83e-01
ERBB2 Activates PTK6 Signaling	13	4.69e-01	6.62e-01	0.19900	1.79e-01	-8.70e-02	2.63e-01	5.87e-01
CaM pathway	32	4.72e-01	6.63e-01	0.12500	-1.25e-01	7.32e-03	2.20e-01	9.43e-01
Calmodulin induced events	32	4.72e-01	6.63e-01	0.12500	-1.25e-01	7.32e-03	2.20e-01	9.43e-01
Metabolism of Angiotensinogen to Angiotensins	17	4.72e-01	6.63e-01	0.17000	-6.41e-02	-1.57e-01	6.47e-01	2.61e-01
Signaling by FGFR2 in disease	38	4.72e-01	6.63e-01	0.11300	9.67e-02	5.93e-02	3.02e-01	5.27e-01
Recognition of DNA damage by PCNA-containing replication complex	28	4.72e-01	6.63e-01	0.13400	-1.33e-01	1.93e-02	2.23e-01	8.59e-01
ERKs are inactivated	12	4.74e-01	6.65e-01	0.20600	-1.86e-01	8.78e-02	2.63e-01	5.98e-01
Signaling by the B Cell Receptor (BCR)	130	4.76e-01	6.67e-01	0.06120	5.34e-02	2.99e-02	2.94e-01	5.57e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	11	4.76e-01	6.67e-01	0.21000	9.20e-02	1.88e-01	5.97e-01	2.79e-01
Thrombin signalling through proteinase activated receptors (PARs)	30	4.78e-01	6.69e-01	0.12900	3.26e-02	-1.25e-01	7.57e-01	2.37e-01
DNA Damage Bypass	44	4.80e-01	6.72e-01	0.10600	-1.02e-01	2.93e-02	2.41e-01	7.37e-01
ABC transporters in lipid homeostasis	17	4.81e-01	6.72e-01	0.16900	2.50e-02	1.67e-01	8.59e-01	2.34e-01
Processive synthesis on the lagging strand	14	4.82e-01	6.73e-01	0.18900	9.18e-02	-1.65e-01	5.52e-01	2.85e-01
GRB2 events in ERBB2 signaling	16	4.83e-01	6.73e-01	0.17400	1.74e-01	1.29e-03	2.28e-01	9.93e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	29	4.87e-01	6.79e-01	0.12800	-6.10e-03	-1.28e-01	9.55e-01	2.32e-01
Signaling by FGFR1 in disease	35	4.88e-01	6.79e-01	0.11500	9.52e-02	6.53e-02	3.30e-01	5.04e-01
Maturation of nucleoprotein	10	4.88e-01	6.79e-01	0.22000	-2.11e-01	6.46e-02	2.48e-01	7.23e-01
Glutamate Neurotransmitter Release Cycle	24	4.89e-01	6.79e-01	0.14000	3.60e-02	1.35e-01	7.60e-01	2.51e-01
Cargo concentration in the ER	29	4.90e-01	6.79e-01	0.13000	-8.13e-02	1.02e-01	4.48e-01	3.44e-01
Organelle biogenesis and maintenance	265	4.90e-01	6.79e-01	0.04280	-4.65e-03	4.25e-02	8.96e-01	2.34e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	43	4.90e-01	6.79e-01	0.10600	-9.93e-02	3.78e-02	2.60e-01	6.68e-01
PI-3K cascade:FGFR1	18	4.91e-01	6.80e-01	0.16400	1.48e-01	-7.05e-02	2.76e-01	6.05e-01
Ion transport by P-type ATPases	51	4.93e-01	6.82e-01	0.09490	-6.47e-02	-6.94e-02	4.24e-01	3.92e-01
Transcription of the HIV genome	68	4.94e-01	6.82e-01	0.08230	3.87e-02	7.27e-02	5.82e-01	3.00e-01
SLC transporter disorders	95	4.95e-01	6.84e-01	0.07130	6.23e-02	-3.46e-02	2.94e-01	5.60e-01
Depolymerisation of the Nuclear Lamina	15	4.97e-01	6.85e-01	0.17900	1.49e-01	-9.92e-02	3.19e-01	5.06e-01
Elevation of cytosolic Ca2+ levels	16	4.98e-01	6.85e-01	0.17300	1.08e-01	-1.35e-01	4.56e-01	3.48e-01
PLC beta mediated events	50	4.98e-01	6.85e-01	0.09560	-9.04e-02	-3.11e-02	2.69e-01	7.03e-01
Interaction between L1 and Ankyrins	29	4.99e-01	6.85e-01	0.12800	-1.05e-01	7.42e-02	3.29e-01	4.90e-01
Nucleotide-like (purinergic) receptors	15	5.00e-01	6.85e-01	0.17700	-5.33e-02	1.69e-01	7.21e-01	2.57e-01
TP53 Regulates Transcription of Cell Cycle Genes	47	5.00e-01	6.85e-01	0.09980	1.70e-02	-9.83e-02	8.40e-01	2.44e-01
Biosynthesis of specialized proresolving mediators (SPMs)	17	5.00e-01	6.85e-01	0.16700	1.37e-01	-9.65e-02	3.30e-01	4.91e-01
Pyrimidine salvage	10	5.01e-01	6.86e-01	0.21800	-1.64e-01	1.43e-01	3.70e-01	4.33e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	13	5.01e-01	6.86e-01	0.18800	-1.88e-01	-1.07e-02	2.42e-01	9.47e-01
Methylation	14	5.02e-01	6.86e-01	0.18300	-6.28e-02	1.72e-01	6.84e-01	2.66e-01
PERK regulates gene expression	31	5.03e-01	6.86e-01	0.12200	1.22e-01	-8.70e-03	2.41e-01	9.33e-01
Signaling by FGFR3	36	5.04e-01	6.88e-01	0.11400	1.07e-01	-3.93e-02	2.68e-01	6.83e-01
Regulation of TP53 Activity through Methylation	16	5.06e-01	6.90e-01	0.16700	6.75e-02	1.52e-01	6.40e-01	2.92e-01
Miscellaneous transport and binding events	23	5.08e-01	6.92e-01	0.13900	-5.38e-02	-1.28e-01	6.55e-01	2.89e-01
Caspase activation via Death Receptors in the presence of ligand	11	5.09e-01	6.92e-01	0.20500	9.32e-02	-1.82e-01	5.93e-01	2.95e-01
Translesion synthesis by REV1	15	5.10e-01	6.92e-01	0.17300	-1.73e-01	3.97e-03	2.46e-01	9.79e-01
Transport of Ribonucleoproteins into the Host Nucleus	31	5.10e-01	6.92e-01	0.12200	8.39e-02	-8.87e-02	4.19e-01	3.93e-01
HDR through MMEJ (alt-NHEJ)	10	5.10e-01	6.92e-01	0.21100	-1.47e-02	-2.11e-01	9.36e-01	2.48e-01
Activation of BH3-only proteins	27	5.11e-01	6.92e-01	0.12900	-1.29e-01	9.44e-03	2.47e-01	9.32e-01
Heme degradation	13	5.12e-01	6.93e-01	0.18300	-9.79e-02	-1.55e-01	5.41e-01	3.35e-01
Negative epigenetic regulation of rRNA expression	57	5.13e-01	6.93e-01	0.08750	3.81e-02	7.87e-02	6.19e-01	3.04e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins	10	5.14e-01	6.93e-01	0.21300	-1.99e-01	7.53e-02	2.76e-01	6.80e-01
Resolution of Abasic Sites (AP sites)	37	5.14e-01	6.93e-01	0.11100	6.27e-02	-9.18e-02	5.10e-01	3.34e-01
Metabolic disorders of biological oxidation enzymes	32	5.14e-01	6.93e-01	0.11900	1.12e-01	-4.13e-02	2.75e-01	6.86e-01
Metabolism of steroid hormones	27	5.15e-01	6.94e-01	0.12700	-5.68e-02	-1.13e-01	6.10e-01	3.09e-01
Metabolism of porphyrins	24	5.15e-01	6.94e-01	0.13700	-6.54e-02	1.21e-01	5.79e-01	3.05e-01
NF-kB is activated and signals survival	11	5.16e-01	6.94e-01	0.20300	-1.33e-01	1.53e-01	4.44e-01	3.79e-01
RHO GTPases activate KTN1	10	5.16e-01	6.94e-01	0.21200	-7.53e-02	1.98e-01	6.80e-01	2.78e-01
SUMOylation of DNA damage response and repair proteins	73	5.17e-01	6.94e-01	0.07890	5.52e-02	-5.63e-02	4.15e-01	4.06e-01
Urea cycle	10	5.17e-01	6.94e-01	0.20800	-3.84e-02	-2.05e-01	8.34e-01	2.62e-01
Regulation of FZD by ubiquitination	19	5.20e-01	6.96e-01	0.15000	1.43e-01	4.66e-02	2.81e-01	7.25e-01
Basigin interactions	24	5.21e-01	6.97e-01	0.13400	-3.24e-02	-1.30e-01	7.83e-01	2.71e-01
Amyloid fiber formation	56	5.22e-01	6.98e-01	0.08780	-1.02e-02	-8.72e-02	8.95e-01	2.59e-01
Infection with Mycobacterium tuberculosis	25	5.23e-01	6.99e-01	0.13200	-2.24e-02	1.30e-01	8.46e-01	2.60e-01
Defective B3GAT3 causes JDSSDHD	19	5.25e-01	7.00e-01	0.15200	4.29e-02	-1.45e-01	7.46e-01	2.73e-01
Disorders of Developmental Biology	13	5.27e-01	7.00e-01	0.18000	-1.78e-01	-2.77e-02	2.66e-01	8.63e-01
Disorders of Nervous System Development	13	5.27e-01	7.00e-01	0.18000	-1.78e-01	-2.77e-02	2.66e-01	8.63e-01
Loss of function of MECP2 in Rett syndrome	13	5.27e-01	7.00e-01	0.18000	-1.78e-01	-2.77e-02	2.66e-01	8.63e-01
Pervasive developmental disorders	13	5.27e-01	7.00e-01	0.18000	-1.78e-01	-2.77e-02	2.66e-01	8.63e-01
Translesion Synthesis by POLH	16	5.28e-01	7.00e-01	0.16400	-1.61e-01	2.85e-02	2.64e-01	8.44e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	16	5.29e-01	7.00e-01	0.16500	5.64e-02	-1.55e-01	6.96e-01	2.84e-01
Bicarbonate transporters	10	5.29e-01	7.00e-01	0.20500	5.13e-02	1.98e-01	7.79e-01	2.78e-01
Pregnenolone biosynthesis	11	5.29e-01	7.00e-01	0.19900	1.21e-01	-1.59e-01	4.89e-01	3.62e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	5.29e-01	7.00e-01	0.15700	-3.88e-02	-1.52e-01	7.82e-01	2.78e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	5.29e-01	7.00e-01	0.15700	-3.88e-02	-1.52e-01	7.82e-01	2.78e-01
Export of Viral Ribonucleoproteins from Nucleus	32	5.30e-01	7.00e-01	0.11700	8.69e-02	-7.79e-02	3.95e-01	4.46e-01
Synthesis of DNA	115	5.32e-01	7.00e-01	0.05990	3.35e-02	4.97e-02	5.35e-01	3.58e-01
TP53 Regulates Transcription of Cell Death Genes	34	5.32e-01	7.00e-01	0.11200	6.88e-03	-1.11e-01	9.45e-01	2.61e-01
Intrinsic Pathway for Apoptosis	46	5.32e-01	7.00e-01	0.09720	-6.93e-02	6.81e-02	4.16e-01	4.24e-01
Nuclear Envelope (NE) Reassembly	64	5.32e-01	7.00e-01	0.08070	7.91e-02	1.62e-02	2.74e-01	8.23e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	11	5.32e-01	7.00e-01	0.19800	1.21e-01	-1.57e-01	4.88e-01	3.67e-01
Thromboxane signalling through TP receptor	22	5.33e-01	7.00e-01	0.14000	6.54e-02	-1.24e-01	5.96e-01	3.16e-01
ISG15 antiviral mechanism	69	5.33e-01	7.00e-01	0.07770	1.30e-02	7.66e-02	8.52e-01	2.71e-01
Transcriptional Regulation by VENTX	36	5.34e-01	7.01e-01	0.10600	-6.81e-02	-8.17e-02	4.80e-01	3.97e-01
Dopamine Neurotransmitter Release Cycle	23	5.36e-01	7.03e-01	0.13300	1.23e-01	5.08e-02	3.07e-01	6.73e-01
Synthesis of very long-chain fatty acyl-CoAs	24	5.40e-01	7.07e-01	0.13000	-1.29e-01	-1.79e-02	2.73e-01	8.79e-01
Phospholipase C-mediated cascade; FGFR2	15	5.40e-01	7.07e-01	0.16400	1.52e-01	6.06e-02	3.07e-01	6.85e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	5.41e-01	7.07e-01	0.16100	2.36e-02	-1.59e-01	8.70e-01	2.71e-01
Regulation of MECP2 expression and activity	29	5.41e-01	7.07e-01	0.12000	-1.16e-01	3.07e-02	2.81e-01	7.75e-01
PI-3K cascade:FGFR4	17	5.42e-01	7.07e-01	0.15400	1.51e-01	3.13e-02	2.81e-01	8.23e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	10	5.42e-01	7.07e-01	0.20100	1.97e-01	3.88e-02	2.80e-01	8.32e-01
MASTL Facilitates Mitotic Progression	10	5.43e-01	7.07e-01	0.20400	-1.94e-01	6.17e-02	2.88e-01	7.36e-01
PI3K/AKT Signaling in Cancer	97	5.43e-01	7.07e-01	0.06540	1.44e-02	-6.38e-02	8.07e-01	2.78e-01
SUMOylation of transcription cofactors	43	5.45e-01	7.09e-01	0.09710	-9.71e-02	8.17e-04	2.71e-01	9.93e-01
RAB geranylgeranylation	60	5.47e-01	7.11e-01	0.08210	8.20e-02	-3.62e-03	2.72e-01	9.61e-01
Cargo recognition for clathrin-mediated endocytosis	101	5.49e-01	7.12e-01	0.06400	-4.45e-02	4.61e-02	4.40e-01	4.24e-01
Lysosphingolipid and LPA receptors	14	5.49e-01	7.12e-01	0.17000	4.79e-02	-1.63e-01	7.56e-01	2.90e-01
Mitotic Prophase	89	5.50e-01	7.13e-01	0.06790	3.56e-02	-5.78e-02	5.62e-01	3.46e-01
Signaling by EGFR in Cancer	23	5.52e-01	7.15e-01	0.13300	6.17e-02	-1.18e-01	6.09e-01	3.29e-01
The NLRP3 inflammasome	15	5.54e-01	7.17e-01	0.16000	1.36e-01	8.35e-02	3.61e-01	5.76e-01
Removal of the Flap Intermediate	13	5.56e-01	7.19e-01	0.17600	9.78e-02	-1.46e-01	5.42e-01	3.62e-01
Trafficking of GluR2-containing AMPA receptors	17	5.59e-01	7.22e-01	0.15100	-1.50e-01	-1.19e-02	2.84e-01	9.33e-01
Lysine catabolism	12	5.62e-01	7.25e-01	0.18100	-9.57e-02	1.54e-01	5.66e-01	3.56e-01
SHC-mediated cascade:FGFR1	18	5.63e-01	7.26e-01	0.14800	1.30e-01	-6.98e-02	3.40e-01	6.08e-01
Nuclear Receptor transcription pathway	53	5.65e-01	7.28e-01	0.08370	-7.07e-02	-4.48e-02	3.73e-01	5.73e-01
Neurotransmitter receptors and postsynaptic signal transmission	171	5.67e-01	7.29e-01	0.04720	-4.70e-02	-4.20e-03	2.90e-01	9.25e-01
Defective B4GALT7 causes EDS, progeroid type	19	5.72e-01	7.35e-01	0.14200	5.63e-02	-1.30e-01	6.71e-01	3.27e-01
RUNX2 regulates bone development	30	5.73e-01	7.35e-01	0.11100	1.11e-01	8.52e-03	2.94e-01	9.36e-01
Anchoring of the basal body to the plasma membrane	94	5.73e-01	7.35e-01	0.06310	4.04e-03	-6.29e-02	9.46e-01	2.92e-01
AURKA Activation by TPX2	70	5.73e-01	7.35e-01	0.07250	-1.28e-02	-7.14e-02	8.53e-01	3.02e-01
ADORA2B mediated anti-inflammatory cytokines production	108	5.74e-01	7.35e-01	0.05800	-5.20e-02	-2.57e-02	3.50e-01	6.45e-01
Signal amplification	31	5.74e-01	7.35e-01	0.11100	6.95e-02	-8.63e-02	5.03e-01	4.05e-01
Generic Transcription Pathway	966	5.76e-01	7.36e-01	0.01990	-8.53e-03	-1.79e-02	6.55e-01	3.48e-01
DNA Repair	281	5.78e-01	7.38e-01	0.03590	-2.00e-02	-2.98e-02	5.64e-01	3.91e-01
Sema3A PAK dependent Axon repulsion	15	5.79e-01	7.39e-01	0.15400	-9.69e-02	-1.19e-01	5.16e-01	4.24e-01
Transcription of E2F targets under negative control by DREAM complex	19	5.80e-01	7.39e-01	0.14000	9.19e-02	-1.06e-01	4.88e-01	4.24e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	35	5.80e-01	7.39e-01	0.10200	-1.01e-01	1.93e-02	3.03e-01	8.43e-01
Pentose phosphate pathway	14	5.83e-01	7.40e-01	0.15800	1.35e-01	8.21e-02	3.81e-01	5.95e-01
Gastrin-CREB signalling pathway via PKC and MAPK	17	5.83e-01	7.40e-01	0.14700	9.19e-02	-1.15e-01	5.12e-01	4.10e-01
Interleukin-7 signaling	23	5.84e-01	7.40e-01	0.12400	5.03e-02	1.13e-01	6.76e-01	3.49e-01
DNA Replication	122	5.84e-01	7.40e-01	0.05360	4.16e-02	3.38e-02	4.28e-01	5.19e-01
Cyclin D associated events in G1	43	5.84e-01	7.40e-01	0.09020	-4.47e-02	-7.83e-02	6.12e-01	3.74e-01
G1 Phase	43	5.84e-01	7.40e-01	0.09020	-4.47e-02	-7.83e-02	6.12e-01	3.74e-01
Fatty acyl-CoA biosynthesis	35	5.85e-01	7.40e-01	0.10200	-9.97e-02	2.04e-02	3.08e-01	8.34e-01
Interleukin receptor SHC signaling	26	5.85e-01	7.40e-01	0.11900	-7.99e-02	8.84e-02	4.81e-01	4.36e-01
Response of EIF2AK1 (HRI) to heme deficiency	15	5.86e-01	7.40e-01	0.15200	9.70e-02	1.17e-01	5.16e-01	4.32e-01
Signal regulatory protein family interactions	12	5.86e-01	7.40e-01	0.17400	-6.34e-02	1.62e-01	7.04e-01	3.31e-01
Assembly and cell surface presentation of NMDA receptors	23	5.87e-01	7.40e-01	0.12300	4.04e-02	1.16e-01	7.37e-01	3.34e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	10	5.88e-01	7.40e-01	0.18700	4.90e-02	1.80e-01	7.88e-01	3.23e-01
Acyl chain remodelling of PE	26	5.88e-01	7.40e-01	0.11700	2.89e-03	1.17e-01	9.80e-01	3.04e-01
NOD1/2 Signaling Pathway	30	5.88e-01	7.40e-01	0.10800	1.47e-02	1.07e-01	8.89e-01	3.10e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	5.91e-01	7.43e-01	0.08350	4.86e-02	6.79e-02	5.57e-01	4.11e-01
Signaling by ERBB2 ECD mutants	14	5.92e-01	7.44e-01	0.16000	1.03e-01	-1.23e-01	5.07e-01	4.25e-01
RAS processing	19	5.94e-01	7.46e-01	0.13500	1.35e-01	9.95e-04	3.08e-01	9.94e-01
NoRC negatively regulates rRNA expression	54	6.00e-01	7.53e-01	0.07840	4.27e-02	6.58e-02	5.87e-01	4.03e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	6.01e-01	7.53e-01	0.14900	-7.84e-02	-1.26e-01	5.99e-01	3.98e-01
Translesion synthesis by POLK	16	6.02e-01	7.54e-01	0.14600	-1.45e-01	1.01e-02	3.14e-01	9.44e-01
Regulation of signaling by CBL	18	6.04e-01	7.55e-01	0.13700	-1.10e-03	-1.37e-01	9.94e-01	3.15e-01
Processing and activation of SUMO	10	6.04e-01	7.55e-01	0.18400	3.05e-02	-1.82e-01	8.68e-01	3.20e-01
CD28 dependent PI3K/Akt signaling	22	6.05e-01	7.55e-01	0.12200	1.02e-01	6.64e-02	4.07e-01	5.90e-01
Interleukin-12 family signaling	49	6.06e-01	7.56e-01	0.08180	3.12e-02	7.57e-02	7.06e-01	3.60e-01
HCMV Infection	89	6.08e-01	7.57e-01	0.06210	-4.35e-02	4.43e-02	4.78e-01	4.70e-01
Signaling by NTRKs	129	6.08e-01	7.58e-01	0.05030	1.92e-02	4.65e-02	7.07e-01	3.62e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	19	6.11e-01	7.59e-01	0.13200	2.36e-02	-1.30e-01	8.59e-01	3.26e-01
Phosphorylation of CD3 and TCR zeta chains	17	6.11e-01	7.59e-01	0.14000	-1.38e-01	2.49e-02	3.26e-01	8.59e-01
Erythropoietin activates RAS	14	6.16e-01	7.66e-01	0.15300	5.16e-02	-1.44e-01	7.38e-01	3.50e-01
Downregulation of ERBB2 signaling	26	6.17e-01	7.66e-01	0.11000	9.02e-02	6.26e-02	4.26e-01	5.81e-01
FRS-mediated FGFR1 signaling	20	6.18e-01	7.66e-01	0.12900	9.86e-02	-8.26e-02	4.45e-01	5.22e-01
Signaling by PDGFR in disease	19	6.19e-01	7.67e-01	0.13100	-1.23e-01	4.57e-02	3.54e-01	7.30e-01
S Phase	157	6.20e-01	7.68e-01	0.04520	4.52e-02	-5.42e-04	3.28e-01	9.91e-01
SHC-mediated cascade:FGFR4	17	6.22e-01	7.70e-01	0.13500	1.32e-01	3.20e-02	3.48e-01	8.19e-01
Activation of kainate receptors upon glutamate binding	29	6.23e-01	7.70e-01	0.10600	7.22e-02	-7.73e-02	5.01e-01	4.71e-01
Inflammasomes	20	6.24e-01	7.70e-01	0.12500	1.21e-01	3.00e-02	3.49e-01	8.16e-01
CS/DS degradation	14	6.24e-01	7.70e-01	0.15100	1.44e-01	-4.54e-02	3.50e-01	7.68e-01
Nervous system development	512	6.26e-01	7.72e-01	0.02510	-2.50e-02	1.84e-03	3.34e-01	9.43e-01
Synthesis of glycosylphosphatidylinositol (GPI)	17	6.27e-01	7.72e-01	0.13500	-2.01e-03	-1.35e-01	9.89e-01	3.35e-01
Centrosome maturation	79	6.28e-01	7.72e-01	0.06190	-4.24e-02	-4.51e-02	5.15e-01	4.89e-01
Recruitment of mitotic centrosome proteins and complexes	79	6.28e-01	7.72e-01	0.06190	-4.24e-02	-4.51e-02	5.15e-01	4.89e-01
Fanconi Anemia Pathway	35	6.29e-01	7.72e-01	0.09350	-9.12e-02	-2.05e-02	3.50e-01	8.34e-01
Regulation of TP53 Expression and Degradation	34	6.29e-01	7.72e-01	0.09500	1.48e-02	9.38e-02	8.81e-01	3.44e-01
TRP channels	25	6.33e-01	7.76e-01	0.11200	7.79e-02	-8.05e-02	5.00e-01	4.86e-01
Formation of tubulin folding intermediates by CCT/TriC	21	6.34e-01	7.76e-01	0.12200	-7.65e-02	9.51e-02	5.44e-01	4.51e-01
NGF-stimulated transcription	36	6.34e-01	7.76e-01	0.09300	-8.28e-02	4.23e-02	3.90e-01	6.61e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	10	6.36e-01	7.77e-01	0.17300	1.70e-01	3.03e-02	3.52e-01	8.68e-01
Polo-like kinase mediated events	15	6.36e-01	7.77e-01	0.14200	-7.36e-03	-1.41e-01	9.61e-01	3.43e-01
Synthesis of PE	13	6.36e-01	7.77e-01	0.15000	9.65e-02	1.15e-01	5.47e-01	4.73e-01
CD28 co-stimulation	33	6.38e-01	7.78e-01	0.09430	-4.05e-02	-8.52e-02	6.87e-01	3.97e-01
Apoptotic factor-mediated response	14	6.42e-01	7.82e-01	0.14300	8.19e-02	1.17e-01	5.96e-01	4.47e-01
Inhibition of DNA recombination at telomere	29	6.43e-01	7.82e-01	0.10000	-2.94e-02	-9.56e-02	7.84e-01	3.73e-01
Regulation of TP53 Degradation	33	6.44e-01	7.82e-01	0.09480	-1.38e-02	9.38e-02	8.91e-01	3.51e-01
Bile acid and bile salt metabolism	37	6.44e-01	7.82e-01	0.08810	-3.88e-02	-7.91e-02	6.83e-01	4.05e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	6.45e-01	7.82e-01	0.12600	8.01e-02	-9.71e-02	5.45e-01	4.64e-01
FGFR1 ligand binding and activation	12	6.45e-01	7.82e-01	0.15800	1.26e-01	-9.55e-02	4.49e-01	5.67e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	6.45e-01	7.82e-01	0.10300	-3.96e-02	9.54e-02	7.17e-01	3.82e-01
Prolonged ERK activation events	14	6.48e-01	7.86e-01	0.14600	-1.20e-01	8.22e-02	4.36e-01	5.94e-01
VEGFR2 mediated vascular permeability	26	6.51e-01	7.88e-01	0.10600	-7.09e-02	7.94e-02	5.32e-01	4.83e-01
DNA Double Strand Break Response	46	6.53e-01	7.90e-01	0.07970	4.15e-02	-6.80e-02	6.26e-01	4.25e-01
Regulation of PLK1 Activity at G2/M Transition	83	6.55e-01	7.92e-01	0.05750	-3.84e-02	-4.29e-02	5.46e-01	5.00e-01
Opioid Signalling	86	6.56e-01	7.92e-01	0.05740	-5.72e-02	4.04e-03	3.59e-01	9.48e-01
Metabolism of non-coding RNA	51	6.57e-01	7.92e-01	0.07380	7.24e-02	1.41e-02	3.71e-01	8.62e-01
snRNP Assembly	51	6.57e-01	7.92e-01	0.07380	7.24e-02	1.41e-02	3.71e-01	8.62e-01
MAP2K and MAPK activation	38	6.58e-01	7.92e-01	0.08470	-4.75e-02	-7.01e-02	6.12e-01	4.55e-01
Prostacyclin signalling through prostacyclin receptor	18	6.58e-01	7.92e-01	0.12600	5.81e-02	-1.12e-01	6.70e-01	4.11e-01
Transcriptional regulation by small RNAs	54	6.63e-01	7.98e-01	0.07230	4.10e-02	-5.95e-02	6.02e-01	4.49e-01
Transport of vitamins, nucleosides, and related molecules	41	6.65e-01	7.98e-01	0.08120	-1.09e-02	-8.05e-02	9.04e-01	3.73e-01
SIRT1 negatively regulates rRNA expression	18	6.65e-01	7.98e-01	0.12300	1.49e-02	-1.23e-01	9.13e-01	3.68e-01
Trafficking and processing of endosomal TLR	12	6.66e-01	7.99e-01	0.14800	1.13e-01	9.52e-02	4.96e-01	5.68e-01
Sphingolipid metabolism	83	6.66e-01	7.99e-01	0.05800	-3.07e-02	4.92e-02	6.29e-01	4.38e-01
IKK complex recruitment mediated by RIP1	18	6.67e-01	7.99e-01	0.12100	1.13e-01	4.50e-02	4.08e-01	7.41e-01
Signaling by ERBB2 TMD/JMD mutants	20	6.68e-01	7.99e-01	0.11700	1.08e-01	-4.65e-02	4.05e-01	7.19e-01
Negative regulation of MET activity	20	6.69e-01	7.99e-01	0.11700	-9.82e-02	6.43e-02	4.47e-01	6.18e-01
Laminin interactions	23	6.70e-01	8.00e-01	0.10700	-1.05e-01	-2.15e-02	3.83e-01	8.59e-01
Stimuli-sensing channels	96	6.70e-01	8.00e-01	0.05330	1.76e-02	-5.03e-02	7.66e-01	3.94e-01
G2/M Transition	175	6.71e-01	8.01e-01	0.03900	3.50e-03	3.89e-02	9.36e-01	3.75e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	12	6.73e-01	8.02e-01	0.14800	7.38e-03	1.48e-01	9.65e-01	3.75e-01
Formation of ATP by chemiosmotic coupling	15	6.74e-01	8.03e-01	0.13300	-4.98e-03	1.32e-01	9.73e-01	3.75e-01
Gap junction assembly	16	6.75e-01	8.03e-01	0.12600	-1.10e-01	-6.20e-02	4.46e-01	6.68e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	6.77e-01	8.05e-01	0.13400	1.01e-01	8.85e-02	5.13e-01	5.67e-01
RNA polymerase II transcribes snRNA genes	68	6.79e-01	8.06e-01	0.06260	-4.12e-02	4.72e-02	5.57e-01	5.01e-01
RNA Polymerase II Pre-transcription Events	79	6.80e-01	8.06e-01	0.05780	-2.04e-02	5.41e-02	7.54e-01	4.06e-01
Activation of BAD and translocation to mitochondria	15	6.81e-01	8.07e-01	0.13300	-1.04e-01	8.26e-02	4.86e-01	5.80e-01
HS-GAG biosynthesis	28	6.81e-01	8.07e-01	0.09440	-5.95e-02	-7.32e-02	5.86e-01	5.02e-01
Regulation of signaling by NODAL	10	6.82e-01	8.07e-01	0.15900	-2.89e-02	-1.56e-01	8.74e-01	3.92e-01
Clathrin-mediated endocytosis	138	6.82e-01	8.07e-01	0.04360	-4.07e-02	1.54e-02	4.09e-01	7.55e-01
Antiviral mechanism by IFN-stimulated genes	77	6.84e-01	8.08e-01	0.05710	1.35e-02	5.55e-02	8.37e-01	4.00e-01
Interleukin-2 family signaling	41	6.84e-01	8.08e-01	0.07980	-5.45e-02	5.83e-02	5.46e-01	5.19e-01
Neutrophil degranulation	441	6.85e-01	8.09e-01	0.02450	-9.76e-03	2.24e-02	7.26e-01	4.20e-01
Acyl chain remodelling of PG	17	6.87e-01	8.09e-01	0.12000	1.14e-01	3.75e-02	4.14e-01	7.89e-01
Intraflagellar transport	38	6.87e-01	8.09e-01	0.08100	-7.59e-03	-8.07e-02	9.35e-01	3.90e-01
Signaling by SCF-KIT	42	6.88e-01	8.09e-01	0.07710	-1.16e-03	-7.71e-02	9.90e-01	3.87e-01
Organic cation/anion/zwitterion transport	12	6.88e-01	8.09e-01	0.14500	1.31e-02	-1.44e-01	9.37e-01	3.88e-01
Plasma lipoprotein clearance	32	6.90e-01	8.11e-01	0.08800	-3.78e-03	8.79e-02	9.70e-01	3.89e-01
Regulation of PTEN mRNA translation	21	6.94e-01	8.15e-01	0.10900	4.37e-02	-9.98e-02	7.29e-01	4.29e-01
Detoxification of Reactive Oxygen Species	32	6.96e-01	8.15e-01	0.08660	1.42e-02	8.54e-02	8.90e-01	4.03e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	23	6.96e-01	8.15e-01	0.10300	-1.00e-01	2.40e-02	4.05e-01	8.42e-01
HCMV Early Events	67	6.96e-01	8.15e-01	0.06080	2.34e-02	-5.61e-02	7.41e-01	4.27e-01
PCNA-Dependent Long Patch Base Excision Repair	20	6.97e-01	8.16e-01	0.10900	-1.06e-01	-2.54e-02	4.12e-01	8.44e-01
Phospholipase C-mediated cascade: FGFR1	13	6.99e-01	8.17e-01	0.13700	7.33e-02	-1.16e-01	6.47e-01	4.68e-01
Ca-dependent events	34	7.00e-01	8.18e-01	0.08350	-8.34e-02	-4.85e-03	4.00e-01	9.61e-01
Interconversion of nucleotide di- and triphosphates	28	7.02e-01	8.19e-01	0.09210	9.17e-02	-8.07e-03	4.01e-01	9.41e-01
Recruitment of NuMA to mitotic centrosomes	78	7.04e-01	8.20e-01	0.05410	-3.23e-02	-4.34e-02	6.22e-01	5.08e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	7.05e-01	8.20e-01	0.14100	8.29e-02	-1.15e-01	6.19e-01	4.92e-01
Loss of Nlp from mitotic centrosomes	67	7.06e-01	8.20e-01	0.05820	-3.09e-02	-4.93e-02	6.62e-01	4.85e-01
Loss of proteins required for interphase microtubule organization from the centrosome	67	7.06e-01	8.20e-01	0.05820	-3.09e-02	-4.93e-02	6.62e-01	4.85e-01
Insulin processing	27	7.07e-01	8.20e-01	0.09170	-8.61e-02	-3.17e-02	4.39e-01	7.76e-01
Mitotic G2-G2/M phases	177	7.08e-01	8.20e-01	0.03600	7.61e-03	3.52e-02	8.61e-01	4.20e-01
Ion channel transport	168	7.08e-01	8.20e-01	0.03760	1.99e-02	-3.19e-02	6.56e-01	4.75e-01
Digestion	16	7.08e-01	8.20e-01	0.12100	6.37e-02	-1.03e-01	6.59e-01	4.74e-01
Diseases associated with visual transduction	13	7.09e-01	8.20e-01	0.13400	3.67e-02	-1.29e-01	8.19e-01	4.21e-01
Diseases of the neuronal system	13	7.09e-01	8.20e-01	0.13400	3.67e-02	-1.29e-01	8.19e-01	4.21e-01
Retinoid cycle disease events	13	7.09e-01	8.20e-01	0.13400	3.67e-02	-1.29e-01	8.19e-01	4.21e-01
Translesion synthesis by POLI	16	7.09e-01	8.20e-01	0.12100	-1.16e-01	3.22e-02	4.21e-01	8.24e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	10	7.10e-01	8.20e-01	0.15300	1.21e-01	-9.48e-02	5.09e-01	6.04e-01
Scavenging by Class A Receptors	17	7.10e-01	8.20e-01	0.11700	1.03e-01	-5.65e-02	4.63e-01	6.87e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	19	7.11e-01	8.20e-01	0.10900	-1.75e-02	-1.08e-01	8.95e-01	4.17e-01
Retrograde transport at the Trans-Golgi-Network	46	7.11e-01	8.20e-01	0.07070	-1.20e-02	6.96e-02	8.88e-01	4.14e-01
Synthesis of PA	37	7.12e-01	8.20e-01	0.07930	6.78e-02	-4.11e-02	4.76e-01	6.65e-01
FGFR4 ligand binding and activation	11	7.13e-01	8.21e-01	0.14200	1.28e-01	5.95e-02	4.61e-01	7.33e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	7.17e-01	8.25e-01	0.09480	-5.42e-02	-7.78e-02	6.46e-01	5.10e-01
Recycling pathway of L1	27	7.18e-01	8.25e-01	0.09100	-8.95e-02	1.66e-02	4.21e-01	8.81e-01
RNA Polymerase I Promoter Opening	13	7.19e-01	8.26e-01	0.13100	3.98e-02	-1.25e-01	8.04e-01	4.36e-01
RUNX3 regulates NOTCH signaling	12	7.20e-01	8.26e-01	0.13400	-1.27e-01	-4.11e-02	4.45e-01	8.05e-01
Cell recruitment (pro-inflammatory response)	22	7.22e-01	8.27e-01	0.09930	-1.66e-03	-9.93e-02	9.89e-01	4.20e-01
Purinergic signaling in leishmaniasis infection	22	7.22e-01	8.27e-01	0.09930	-1.66e-03	-9.93e-02	9.89e-01	4.20e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	10	7.23e-01	8.28e-01	0.14800	3.06e-02	-1.45e-01	8.67e-01	4.29e-01
MET activates PTK2 signaling	18	7.32e-01	8.37e-01	0.10700	-1.04e-01	-2.54e-02	4.46e-01	8.52e-01
Signaling by ERBB4	53	7.33e-01	8.37e-01	0.06340	-5.05e-02	3.84e-02	5.25e-01	6.28e-01
Apoptotic execution phase	51	7.33e-01	8.37e-01	0.06330	-1.39e-02	-6.18e-02	8.64e-01	4.45e-01
B-WICH complex positively regulates rRNA expression	39	7.35e-01	8.38e-01	0.07190	3.10e-02	6.48e-02	7.38e-01	4.84e-01
Signaling by Activin	13	7.38e-01	8.42e-01	0.12600	5.08e-02	-1.15e-01	7.51e-01	4.71e-01
Regulation of TP53 Activity through Association with Co-factors	13	7.41e-01	8.43e-01	0.12300	-1.19e-01	-3.27e-02	4.59e-01	8.38e-01
SUMOylation of RNA binding proteins	45	7.41e-01	8.43e-01	0.06750	3.68e-02	-5.66e-02	6.69e-01	5.11e-01
Response to elevated platelet cytosolic Ca2+	128	7.42e-01	8.43e-01	0.03900	-3.11e-02	-2.35e-02	5.43e-01	6.46e-01
HCMV Late Events	61	7.42e-01	8.43e-01	0.05770	-2.14e-02	5.36e-02	7.72e-01	4.69e-01
Signaling by WNT	270	7.46e-01	8.46e-01	0.02750	-1.65e-02	2.20e-02	6.40e-01	5.35e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	15	7.47e-01	8.47e-01	0.11300	-3.20e-02	-1.08e-01	8.30e-01	4.68e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	39	7.48e-01	8.47e-01	0.06980	-2.92e-02	-6.34e-02	7.52e-01	4.93e-01
Caspase activation via extrinsic apoptotic signalling pathway	21	7.51e-01	8.49e-01	0.09670	6.35e-02	-7.30e-02	6.15e-01	5.63e-01
Axon guidance	489	7.51e-01	8.49e-01	0.02010	-2.00e-02	2.13e-03	4.51e-01	9.36e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	42	7.51e-01	8.49e-01	0.06650	3.67e-02	5.55e-02	6.81e-01	5.34e-01
Signal attenuation	10	7.52e-01	8.49e-01	0.13600	-6.93e-02	-1.17e-01	7.05e-01	5.21e-01
Nicotinate metabolism	31	7.52e-01	8.49e-01	0.07840	7.84e-02	-1.43e-03	4.50e-01	9.89e-01
Nonhomologous End-Joining (NHEJ)	40	7.53e-01	8.49e-01	0.06920	1.22e-02	-6.81e-02	8.94e-01	4.56e-01
Platelet Adhesion to exposed collagen	13	7.53e-01	8.49e-01	0.12000	-1.18e-01	-2.42e-02	4.63e-01	8.80e-01
Activation of RAC1	13	7.54e-01	8.50e-01	0.12000	-2.53e-02	-1.17e-01	8.75e-01	4.66e-01
MET promotes cell motility	29	7.56e-01	8.51e-01	0.07920	-4.53e-02	-6.50e-02	6.73e-01	5.44e-01
FRS-mediated FGFR4 signaling	19	7.57e-01	8.51e-01	0.09870	9.83e-02	7.84e-03	4.58e-01	9.53e-01
Pyrimidine catabolism	12	7.57e-01	8.51e-01	0.12400	-1.23e-01	-1.17e-02	4.59e-01	9.44e-01
Cytochrome c-mediated apoptotic response	11	7.58e-01	8.51e-01	0.13200	-9.05e-02	9.54e-02	6.03e-01	5.84e-01
Signaling by Hippo	20	7.60e-01	8.53e-01	0.09450	-4.21e-02	-8.46e-02	7.45e-01	5.12e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	45	7.62e-01	8.54e-01	0.06420	2.22e-02	-6.02e-02	7.97e-01	4.85e-01
Phase 2 - plateau phase	14	7.62e-01	8.54e-01	0.11500	9.64e-02	-6.33e-02	5.32e-01	6.82e-01
Infectious disease	748	7.63e-01	8.54e-01	0.01600	-3.39e-03	1.56e-02	8.75e-01	4.70e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	7.64e-01	8.55e-01	0.07630	5.74e-02	5.02e-02	5.87e-01	6.34e-01
Protein-protein interactions at synapses	83	7.66e-01	8.56e-01	0.04680	1.49e-02	-4.44e-02	8.15e-01	4.85e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	37	7.67e-01	8.56e-01	0.06890	1.03e-02	6.81e-02	9.14e-01	4.74e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	15	7.67e-01	8.56e-01	0.10900	-3.38e-02	1.04e-01	8.21e-01	4.85e-01
Signaling by NODAL	17	7.68e-01	8.56e-01	0.10000	-6.35e-02	-7.77e-02	6.50e-01	5.79e-01
Regulation of RUNX1 Expression and Activity	23	7.70e-01	8.58e-01	0.08690	-8.63e-02	-1.01e-02	4.74e-01	9.34e-01
Incretin synthesis, secretion, and inactivation	19	7.73e-01	8.61e-01	0.09480	5.69e-03	9.46e-02	9.66e-01	4.75e-01
Metabolism of amine-derived hormones	17	7.75e-01	8.63e-01	0.09920	-2.61e-02	-9.57e-02	8.52e-01	4.95e-01
Termination of O-glycan biosynthesis	17	7.77e-01	8.64e-01	0.09920	-5.78e-03	-9.90e-02	9.67e-01	4.80e-01
SUMOylation of transcription factors	16	7.82e-01	8.68e-01	0.10200	-1.99e-02	9.99e-02	8.90e-01	4.89e-01
Sodium/Calcium exchangers	11	7.84e-01	8.70e-01	0.12000	6.96e-02	9.75e-02	6.89e-01	5.75e-01
COPI-dependent Golgi-to-ER retrograde traffic	78	7.87e-01	8.73e-01	0.04570	-4.45e-02	1.01e-02	4.97e-01	8.78e-01
Signalling to ERKs	33	7.89e-01	8.74e-01	0.06920	2.29e-03	6.92e-02	9.82e-01	4.91e-01
Negative regulation of FGFR2 signaling	29	7.89e-01	8.74e-01	0.07340	1.71e-02	7.14e-02	8.74e-01	5.06e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	10	7.90e-01	8.74e-01	0.12400	1.01e-01	7.19e-02	5.81e-01	6.94e-01
A tetrasaccharide linker sequence is required for GAG synthesis	25	7.92e-01	8.75e-01	0.07840	-1.78e-02	-7.63e-02	8.78e-01	5.09e-01
Triglyceride catabolism	22	7.93e-01	8.75e-01	0.08490	-7.19e-02	4.52e-02	5.59e-01	7.13e-01
VxPx cargo-targeting to cilium	21	7.93e-01	8.75e-01	0.08480	-3.69e-02	-7.64e-02	7.70e-01	5.45e-01
SARS-CoV-2 Infection	64	7.95e-01	8.75e-01	0.04930	-1.07e-02	4.81e-02	8.82e-01	5.06e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	17	7.95e-01	8.75e-01	0.09370	-7.91e-02	-5.02e-02	5.72e-01	7.20e-01
Voltage gated Potassium channels	41	7.95e-01	8.75e-01	0.06160	1.85e-02	-5.88e-02	8.37e-01	5.15e-01
Fertilization	19	7.95e-01	8.75e-01	0.08850	-7.68e-02	-4.41e-02	5.62e-01	7.40e-01
Formation of Incision Complex in GG-NER	42	7.96e-01	8.75e-01	0.06060	-1.06e-02	5.97e-02	9.06e-01	5.04e-01
Negative regulation of FGFR3 signaling	25	8.00e-01	8.79e-01	0.07640	6.95e-02	3.17e-02	5.48e-01	7.84e-01
NOTCH4 Intracellular Domain Regulates Transcription	18	8.03e-01	8.79e-01	0.08900	-6.56e-02	-6.01e-02	6.30e-01	6.59e-01
Purine catabolism	17	8.03e-01	8.79e-01	0.09210	8.85e-02	2.57e-02	5.28e-01	8.55e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	12	8.03e-01	8.79e-01	0.11100	-1.04e-01	4.03e-02	5.33e-01	8.09e-01
Interleukin-4 and Interleukin-13 signaling	101	8.06e-01	8.79e-01	0.03760	-1.11e-02	-3.59e-02	8.48e-01	5.33e-01
Misspliced GSK3beta mutants stabilize beta-catenin	14	8.06e-01	8.79e-01	0.10100	1.05e-02	1.00e-01	9.46e-01	5.15e-01
S33 mutants of beta-catenin aren't phosphorylated	14	8.06e-01	8.79e-01	0.10100	1.05e-02	1.00e-01	9.46e-01	5.15e-01
S37 mutants of beta-catenin aren't phosphorylated	14	8.06e-01	8.79e-01	0.10100	1.05e-02	1.00e-01	9.46e-01	5.15e-01
S45 mutants of beta-catenin aren't phosphorylated	14	8.06e-01	8.79e-01	0.10100	1.05e-02	1.00e-01	9.46e-01	5.15e-01
T41 mutants of beta-catenin aren't phosphorylated	14	8.06e-01	8.79e-01	0.10100	1.05e-02	1.00e-01	9.46e-01	5.15e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	14	8.06e-01	8.79e-01	0.10100	1.05e-02	1.00e-01	9.46e-01	5.15e-01
Reduction of cytosolic Ca++ levels	12	8.09e-01	8.82e-01	0.11000	-5.71e-02	9.39e-02	7.32e-01	5.73e-01
Triglyceride metabolism	35	8.13e-01	8.85e-01	0.06390	-4.57e-02	4.46e-02	6.40e-01	6.48e-01
Disease	1421	8.14e-01	8.85e-01	0.01040	-6.28e-03	8.30e-03	6.94e-01	6.04e-01
Metabolism of nitric oxide: NOS3 activation and regulation	14	8.16e-01	8.87e-01	0.09960	-8.88e-02	4.51e-02	5.65e-01	7.70e-01
Gene Silencing by RNA	84	8.20e-01	8.90e-01	0.03980	3.97e-02	-3.10e-03	5.30e-01	9.61e-01
Activation of Ca-permeable Kainate Receptor	10	8.21e-01	8.90e-01	0.11400	2.60e-02	1.11e-01	8.87e-01	5.43e-01
Ionotropic activity of kainate receptors	10	8.21e-01	8.90e-01	0.11400	2.60e-02	1.11e-01	8.87e-01	5.43e-01
Cargo trafficking to the periciliary membrane	49	8.22e-01	8.91e-01	0.05200	5.07e-02	-1.19e-02	5.40e-01	8.86e-01
Eicosanoid ligand-binding receptors	13	8.28e-01	8.97e-01	0.09980	-6.66e-02	7.44e-02	6.78e-01	6.42e-01
EGFR downregulation	30	8.29e-01	8.97e-01	0.06380	-5.53e-02	-3.19e-02	6.00e-01	7.62e-01
Prefoldin mediated transfer of substrate to CCT/TriC	25	8.30e-01	8.98e-01	0.07130	-3.16e-02	6.39e-02	7.84e-01	5.81e-01
Deactivation of the beta-catenin transactivating complex	39	8.32e-01	9.00e-01	0.05550	-2.09e-02	-5.14e-02	8.21e-01	5.79e-01
Signaling by FGFR2	62	8.33e-01	9.00e-01	0.04470	4.32e-02	-1.16e-02	5.57e-01	8.74e-01
EPH-ephrin mediated repulsion of cells	48	8.35e-01	9.00e-01	0.04960	4.45e-02	2.18e-02	5.94e-01	7.94e-01
Signalling to RAS	19	8.35e-01	9.00e-01	0.07890	2.26e-02	7.56e-02	8.65e-01	5.69e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	13	8.35e-01	9.00e-01	0.09750	7.25e-02	-6.52e-02	6.51e-01	6.84e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	30	8.36e-01	9.00e-01	0.06400	3.97e-02	-5.02e-02	7.07e-01	6.35e-01
Glutathione synthesis and recycling	12	8.36e-01	9.00e-01	0.09820	6.56e-02	7.31e-02	6.94e-01	6.61e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	11	8.37e-01	9.00e-01	0.10300	-1.01e-01	-1.96e-02	5.60e-01	9.10e-01
Signaling by MET	66	8.42e-01	9.04e-01	0.04180	-8.03e-04	4.18e-02	9.91e-01	5.57e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	13	8.42e-01	9.04e-01	0.09500	-4.42e-02	8.40e-02	7.82e-01	6.00e-01
Signaling by EGFR	49	8.42e-01	9.04e-01	0.04790	-4.38e-02	-1.93e-02	5.96e-01	8.15e-01
Negative regulation of FGFR4 signaling	26	8.46e-01	9.07e-01	0.06650	-3.61e-02	5.58e-02	7.50e-01	6.22e-01
Beta-catenin phosphorylation cascade	16	8.49e-01	9.08e-01	0.08200	7.82e-02	2.46e-02	5.88e-01	8.65e-01
Cardiac conduction	116	8.50e-01	9.08e-01	0.03070	-2.89e-03	3.06e-02	9.57e-01	5.69e-01
Signaling by PDGFRA extracellular domain mutants	12	8.50e-01	9.08e-01	0.09350	6.89e-02	6.32e-02	6.79e-01	7.04e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	8.50e-01	9.08e-01	0.09350	6.89e-02	6.32e-02	6.79e-01	7.04e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	19	8.52e-01	9.08e-01	0.07620	-5.69e-02	5.07e-02	6.68e-01	7.02e-01
Neurodegenerative Diseases	19	8.52e-01	9.08e-01	0.07620	-5.69e-02	5.07e-02	6.68e-01	7.02e-01
Positive epigenetic regulation of rRNA expression	52	8.52e-01	9.08e-01	0.04590	-2.30e-02	3.97e-02	7.74e-01	6.20e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	8.52e-01	9.08e-01	0.10400	-4.94e-02	9.20e-02	7.87e-01	6.14e-01
Tie2 Signaling	18	8.54e-01	9.09e-01	0.07630	7.63e-02	2.20e-03	5.75e-01	9.87e-01
RHO GTPases activate IQGAPs	11	8.55e-01	9.09e-01	0.09860	-9.16e-02	3.66e-02	5.99e-01	8.34e-01
SUMOylation of immune response proteins	10	8.57e-01	9.09e-01	0.10200	-5.96e-04	1.02e-01	9.97e-01	5.78e-01
Signaling by KIT in disease	20	8.58e-01	9.09e-01	0.07260	-4.40e-02	5.78e-02	7.34e-01	6.55e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	8.58e-01	9.09e-01	0.07260	-4.40e-02	5.78e-02	7.34e-01	6.55e-01
Platelet degranulation	123	8.59e-01	9.09e-01	0.02860	-2.65e-02	-1.06e-02	6.11e-01	8.40e-01
Constitutive Signaling by EGFRvIII	14	8.59e-01	9.09e-01	0.08640	6.94e-02	-5.15e-02	6.53e-01	7.39e-01
Signaling by EGFRvIII in Cancer	14	8.59e-01	9.09e-01	0.08640	6.94e-02	-5.15e-02	6.53e-01	7.39e-01
Alpha-protein kinase 1 signaling pathway	10	8.59e-01	9.09e-01	0.10200	-6.35e-02	8.01e-02	7.28e-01	6.61e-01
Oncogene Induced Senescence	30	8.59e-01	9.09e-01	0.05810	-1.28e-03	-5.81e-02	9.90e-01	5.82e-01
Protein folding	94	8.60e-01	9.10e-01	0.03230	2.01e-02	2.52e-02	7.36e-01	6.73e-01
Peptide hormone metabolism	79	8.65e-01	9.14e-01	0.03470	-3.25e-02	-1.21e-02	6.18e-01	8.53e-01
ATF4 activates genes in response to endoplasmic reticulum stress	26	8.67e-01	9.15e-01	0.06110	5.66e-02	-2.32e-02	6.18e-01	8.38e-01
Processing of Capped Intronless Pre-mRNA	26	8.69e-01	9.17e-01	0.06040	-1.18e-02	5.92e-02	9.17e-01	6.01e-01
Mitotic G1 phase and G1/S transition	143	8.72e-01	9.19e-01	0.02530	2.48e-02	4.78e-03	6.09e-01	9.22e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	40	8.76e-01	9.23e-01	0.04670	-4.61e-02	-7.46e-03	6.14e-01	9.35e-01
Lewis blood group biosynthesis	14	8.78e-01	9.24e-01	0.07760	5.00e-02	5.92e-02	7.46e-01	7.01e-01
Viral Messenger RNA Synthesis	41	8.78e-01	9.24e-01	0.04570	4.43e-02	1.11e-02	6.24e-01	9.02e-01
CRMPs in Sema3A signaling	16	8.83e-01	9.28e-01	0.07110	-4.37e-02	-5.61e-02	7.62e-01	6.98e-01
RIPK1-mediated regulated necrosis	24	8.85e-01	9.28e-01	0.05900	3.25e-02	-4.93e-02	7.83e-01	6.76e-01
Regulated Necrosis	24	8.85e-01	9.28e-01	0.05900	3.25e-02	-4.93e-02	7.83e-01	6.76e-01
Regulation of necroptotic cell death	24	8.85e-01	9.28e-01	0.05900	3.25e-02	-4.93e-02	7.83e-01	6.76e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	28	8.86e-01	9.28e-01	0.05330	-1.73e-02	-5.04e-02	8.74e-01	6.45e-01
Early Phase of HIV Life Cycle	13	8.90e-01	9.32e-01	0.07760	7.58e-02	-1.67e-02	6.36e-01	9.17e-01
Platelet calcium homeostasis	28	8.94e-01	9.33e-01	0.05250	3.71e-02	-3.72e-02	7.34e-01	7.34e-01
Synaptic adhesion-like molecules	21	8.94e-01	9.33e-01	0.05900	-5.25e-02	-2.69e-02	6.77e-01	8.31e-01
Regulation of TP53 Activity	149	8.94e-01	9.33e-01	0.02220	-7.72e-03	-2.08e-02	8.71e-01	6.61e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	11	8.96e-01	9.33e-01	0.08160	1.82e-03	8.16e-02	9.92e-01	6.39e-01
Blood group systems biosynthesis	18	8.98e-01	9.33e-01	0.06330	-4.45e-03	6.32e-02	9.74e-01	6.43e-01
CTLA4 inhibitory signaling	21	8.98e-01	9.33e-01	0.05910	-2.55e-02	5.33e-02	8.40e-01	6.73e-01
Signaling by Receptor Tyrosine Kinases	458	8.99e-01	9.33e-01	0.01280	6.08e-03	-1.13e-02	8.24e-01	6.80e-01
AMER1 mutants destabilize the destruction complex	13	8.99e-01	9.33e-01	0.07390	-3.19e-03	7.38e-02	9.84e-01	6.45e-01
APC truncation mutants have impaired AXIN binding	13	8.99e-01	9.33e-01	0.07390	-3.19e-03	7.38e-02	9.84e-01	6.45e-01
AXIN missense mutants destabilize the destruction complex	13	8.99e-01	9.33e-01	0.07390	-3.19e-03	7.38e-02	9.84e-01	6.45e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling	13	8.99e-01	9.33e-01	0.07390	-3.19e-03	7.38e-02	9.84e-01	6.45e-01
Truncations of AMER1 destabilize the destruction complex	13	8.99e-01	9.33e-01	0.07390	-3.19e-03	7.38e-02	9.84e-01	6.45e-01
truncated APC mutants destabilize the destruction complex	13	8.99e-01	9.33e-01	0.07390	-3.19e-03	7.38e-02	9.84e-01	6.45e-01
Termination of translesion DNA synthesis	30	9.01e-01	9.34e-01	0.04740	-3.45e-02	-3.25e-02	7.44e-01	7.58e-01
Phospholipase C-mediated cascade; FGFR4	12	9.02e-01	9.35e-01	0.07490	7.08e-02	2.42e-02	6.71e-01	8.85e-01
Processing of Intronless Pre-mRNAs	18	9.05e-01	9.37e-01	0.06120	-5.74e-02	2.13e-02	6.73e-01	8.76e-01
LGI-ADAM interactions	13	9.07e-01	9.38e-01	0.07110	-1.74e-02	6.89e-02	9.14e-01	6.67e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	13	9.08e-01	9.38e-01	0.07100	-1.73e-02	6.88e-02	9.14e-01	6.67e-01
Golgi Cisternae Pericentriolar Stack Reorganization	12	9.09e-01	9.39e-01	0.07280	-2.26e-03	7.28e-02	9.89e-01	6.62e-01
MET activates RAS signaling	11	9.10e-01	9.39e-01	0.07450	-5.41e-02	-5.13e-02	7.56e-01	7.68e-01
Signaling by FGFR4	36	9.13e-01	9.42e-01	0.04170	3.06e-02	-2.84e-02	7.51e-01	7.68e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	19	9.15e-01	9.43e-01	0.05520	4.08e-02	3.72e-02	7.58e-01	7.79e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	22	9.16e-01	9.43e-01	0.05100	2.60e-02	4.39e-02	8.33e-01	7.22e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	41	9.17e-01	9.44e-01	0.03810	1.91e-02	-3.30e-02	8.33e-01	7.15e-01
Neurotransmitter release cycle	48	9.24e-01	9.50e-01	0.03350	-1.04e-02	3.18e-02	9.01e-01	7.03e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	17	9.25e-01	9.50e-01	0.05490	5.16e-02	1.85e-02	7.12e-01	8.95e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	17	9.25e-01	9.50e-01	0.05490	5.16e-02	1.85e-02	7.12e-01	8.95e-01
Downregulation of ERBB2:ERBB3 signaling	12	9.25e-01	9.50e-01	0.06660	-5.26e-02	4.09e-02	7.53e-01	8.06e-01
Gap junction trafficking and regulation	26	9.28e-01	9.52e-01	0.04320	-2.94e-02	-3.16e-02	7.95e-01	7.81e-01
Receptor-type tyrosine-protein phosphatases	18	9.33e-01	9.56e-01	0.05030	1.18e-02	4.89e-02	9.31e-01	7.20e-01
FGFR2 alternative splicing	22	9.34e-01	9.56e-01	0.04540	-6.79e-03	-4.49e-02	9.56e-01	7.15e-01
Initiation of Nuclear Envelope (NE) Reformation	16	9.34e-01	9.56e-01	0.05380	-5.12e-02	1.67e-02	7.23e-01	9.08e-01
Diseases of programmed cell death	25	9.35e-01	9.56e-01	0.04200	8.84e-03	4.10e-02	9.39e-01	7.22e-01
Chaperonin-mediated protein folding	88	9.36e-01	9.56e-01	0.02270	-1.16e-02	1.95e-02	8.50e-01	7.51e-01
Transport of Mature mRNA Derived from an Intronless Transcript	40	9.37e-01	9.57e-01	0.03350	1.80e-02	-2.82e-02	8.43e-01	7.58e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	10	9.39e-01	9.58e-01	0.06390	2.97e-02	5.66e-02	8.71e-01	7.57e-01
Phase 0 - rapid depolarisation	30	9.41e-01	9.60e-01	0.03670	3.67e-02	2.94e-04	7.28e-01	9.98e-01
Mismatch Repair	14	9.45e-01	9.63e-01	0.05120	2.29e-02	4.58e-02	8.82e-01	7.67e-01
Carboxyterminal post-translational modifications of tubulin	33	9.46e-01	9.64e-01	0.03330	2.52e-03	3.32e-02	9.80e-01	7.41e-01
BBSome-mediated cargo-targeting to cilium	22	9.47e-01	9.64e-01	0.03990	2.62e-02	3.01e-02	8.32e-01	8.07e-01
P2Y receptors	11	9.50e-01	9.66e-01	0.05630	3.12e-02	-4.69e-02	8.58e-01	7.88e-01
NOTCH2 intracellular domain regulates transcription	10	9.51e-01	9.66e-01	0.05900	4.48e-02	-3.84e-02	8.06e-01	8.34e-01
Synthesis of bile acids and bile salts	29	9.51e-01	9.66e-01	0.03400	-5.61e-03	3.35e-02	9.58e-01	7.55e-01
Caspase activation via Dependence Receptors in the absence of ligand	10	9.52e-01	9.66e-01	0.05640	3.07e-02	4.73e-02	8.67e-01	7.95e-01
Negative regulation of FGFR1 signaling	27	9.54e-01	9.68e-01	0.03360	-3.10e-02	-1.30e-02	7.80e-01	9.07e-01
Estrogen-dependent gene expression	96	9.55e-01	9.68e-01	0.01790	1.88e-04	1.79e-02	9.97e-01	7.62e-01
Platelet homeostasis	81	9.56e-01	9.69e-01	0.01930	2.89e-03	-1.91e-02	9.64e-01	7.67e-01
Signaling by WNT in cancer	33	9.59e-01	9.71e-01	0.02890	-1.57e-03	-2.88e-02	9.88e-01	7.74e-01
Interleukin-12 signaling	39	9.60e-01	9.71e-01	0.02610	2.20e-02	1.40e-02	8.12e-01	8.80e-01
Triglyceride biosynthesis	13	9.64e-01	9.73e-01	0.04350	-1.19e-03	4.35e-02	9.94e-01	7.86e-01
eNOS activation	10	9.64e-01	9.73e-01	0.04970	4.40e-02	-2.31e-02	8.10e-01	8.99e-01
Gap junction trafficking	24	9.65e-01	9.73e-01	0.03150	3.12e-02	4.68e-03	7.92e-01	9.68e-01
Deadenylation of mRNA	20	9.66e-01	9.75e-01	0.03330	2.61e-02	2.07e-02	8.40e-01	8.73e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	17	9.69e-01	9.77e-01	0.03530	-1.19e-02	3.33e-02	9.32e-01	8.12e-01
Gamma-carboxylation of protein precursors	10	9.70e-01	9.77e-01	0.04430	-4.21e-02	-1.37e-02	8.18e-01	9.40e-01
PECAM1 interactions	11	9.76e-01	9.82e-01	0.03860	6.95e-03	-3.80e-02	9.68e-01	8.27e-01
Signaling by Nuclear Receptors	234	9.77e-01	9.82e-01	0.00817	-6.92e-03	-4.33e-03	8.55e-01	9.09e-01
Oxidative Stress Induced Senescence	69	9.78e-01	9.83e-01	0.01450	6.83e-03	1.28e-02	9.22e-01	8.55e-01
Acyl chain remodelling of PS	21	9.96e-01	9.99e-01	0.01150	-2.39e-03	-1.12e-02	9.85e-01	9.29e-01
mRNA Splicing - Minor Pathway	48	9.96e-01	9.99e-01	0.00748	-1.04e-03	-7.40e-03	9.90e-01	9.29e-01
Synthesis, secretion, and deacylation of Ghrelin	17	9.97e-01	9.99e-01	0.00983	3.83e-03	9.05e-03	9.78e-01	9.49e-01
p38MAPK events	13	9.98e-01	9.99e-01	0.01120	1.10e-02	2.14e-03	9.45e-01	9.89e-01
Cytosolic sulfonation of small molecules	23	9.99e-01	9.99e-01	0.00573	-5.11e-03	-2.59e-03	9.66e-01	9.83e-01
Diseases of metabolism	228	9.99e-01	9.99e-01	0.00163	-1.61e-03	3.03e-04	9.67e-01	9.94e-01
Apoptotic cleavage of cellular proteins	38	9.99e-01	9.99e-01	0.00329	-3.27e-03	-3.16e-04	9.72e-01	9.97e-01

---

Detailed Gene set reports

Translation

Translation

metric	value
setSize	261
pMANOVA	5.96e-22
p.adjustMANOVA	8.16e-19
s.dist	0.352
s.skel	0.143
s.heart	0.321
p.skel	7.11e-05
p.heart	4.27e-19

Top 20 genes

Gene	skel	heart
RPL13A	8662	8769
MRPS18B	8262	8890
PTCD3	7969	8800
NARS1	7904	8630
MRPL36	8170	8030
NARS2	7594	8507
MRPL1	8264	7549
MARS2	7803	7855
MRPS14	8631	6963
IARS1	6979	8593
EPRS1	7534	7665
RPL29	8624	6370
HARS2	7265	7381
RPLP2	6247	8473
WARS1	6568	7737
DAP3	7591	6691
MRPS24	8268	5944
MRPL14	6574	7116
EIF2B1	7582	6111
MRPL17	6725	6453

Click HERE to show all gene set members

All member genes

	skel	heart
AARS1	-4806.0	7803.0
AARS2	-6223.0	5546.0
AIMP1	5901.0	2626.0
AIMP2	2900.0	7129.0
APEH	1324.0	3376.0
CARS1	4522.0	4053.0
CARS2	-8348.0	1141.0
CHCHD1	7269.0	2524.0
DAP3	7591.0	6691.0
DARS1	3713.0	-1936.0
DARS2	-4570.0	6989.0
DDOST	1892.0	4386.0
EARS2	6218.0	6675.0
EEF1A1	4479.0	-3572.0
EEF1A2	-781.0	6912.0
EEF1B2	3629.0	-1178.0
EEF1D	-2659.0	6789.0
EEF1E1	5688.5	-6156.5
EEF1G	-587.0	7364.0
EEF2	-3994.0	7672.0
EIF1AX	3275.0	1762.0
EIF2B1	7582.0	6111.0
EIF2B2	2453.0	5487.0
EIF2B3	2800.0	-2282.0
EIF2B4	-321.0	3331.0
EIF2B5	-5420.0	7827.0
EIF2S1	4892.0	-4087.0
EIF2S2	3572.0	4652.0
EIF2S3	134.5	2917.5
EIF3A	-4414.0	2969.0
EIF3B	1074.0	3862.0
EIF3C	1092.5	6687.5
EIF3D	-3804.0	2801.0
EIF3E	7851.0	865.0
EIF3F	-3363.0	-2887.0
EIF3G	-5106.0	5630.0
EIF3H	-5343.0	3656.0
EIF3J	1922.0	5223.0
EIF3K	-7855.0	7472.0
EIF3L	-3104.0	5482.0
EIF3M	-762.0	-4744.0
EIF4A1	1907.0	-2099.0
EIF4A2	6348.0	6429.0
EIF4E	38.0	7538.0
EIF4EBP1	-6373.0	3242.0
EIF4G1	-8382.0	8463.0
EIF4H	-2215.0	-6517.0
EIF5	3307.0	-4224.0
EIF5B	-3547.0	6100.0
EPRS1	7534.0	7665.0
ERAL1	-5371.0	2877.0
ETF1	-32.0	4014.0
FARS2	814.0	8586.0
FARSA	1666.0	3030.0
FARSB	-1329.0	1464.0
FAU	-8349.0	-6727.0
GADD45GIP1	3684.0	5202.0
GARS1	7347.0	4390.0
GFM1	-5362.0	8253.0
GFM2	685.0	8246.0
GSPT1	4620.0	8403.0
GSPT2	2429.0	-6613.0
HARS1	6567.0	3942.0
HARS2	7265.0	7381.0
IARS1	6979.0	8593.0
IARS2	-2969.0	8731.0
KARS1	521.0	6337.0
LARS1	664.0	542.0
LARS2	2455.0	8388.0
MARS1	3978.0	5741.0
MARS2	7803.0	7855.0
MRPL1	8264.0	7549.0
MRPL10	2998.0	8086.0
MRPL11	3525.0	6331.0
MRPL12	3990.0	7781.0
MRPL13	3516.0	5678.0
MRPL14	6574.0	7116.0
MRPL15	997.0	6964.0
MRPL16	-2084.0	1260.0
MRPL17	6725.0	6453.0
MRPL18	3086.0	2055.0
MRPL19	2255.0	7329.0
MRPL2	6957.0	4885.0
MRPL20	4321.0	4290.0
MRPL21	1036.0	1621.0
MRPL22	4861.0	5203.0
MRPL24	5886.0	5906.0
MRPL27	1882.0	-1669.0
MRPL28	-3666.0	7741.0
MRPL3	3631.0	5677.0
MRPL30	-4228.5	8621.5
MRPL32	3203.0	3553.0
MRPL33	2952.0	6991.0
MRPL34	-4124.0	6893.0
MRPL35	3331.0	4469.0
MRPL36	8170.0	8030.0
MRPL37	-7011.0	8256.0
MRPL38	-3883.0	8264.0
MRPL39	287.0	6476.0
MRPL4	-4539.0	7792.0
MRPL40	5081.0	3168.0
MRPL41	-4190.0	1609.0
MRPL42	5782.0	7034.0
MRPL43	2921.0	-1127.0
MRPL44	3657.0	7306.0
MRPL45	5550.0	7688.0
MRPL46	4658.0	6980.0
MRPL47	4297.0	6174.0
MRPL48	-1052.0	994.0
MRPL49	455.0	5109.0
MRPL50	5332.0	5947.0
MRPL51	-6613.0	1221.0
MRPL52	2389.0	3907.0
MRPL53	459.0	6650.0
MRPL54	338.0	6267.0
MRPL55	611.0	5042.0
MRPL58	-2779.0	7028.0
MRPL9	-1324.0	7335.0
MRPS10	-2447.0	2655.0
MRPS11	-727.0	4948.0
MRPS12	-374.0	4749.0
MRPS14	8631.0	6963.0
MRPS15	-320.0	7601.0
MRPS16	2291.0	-1381.0
MRPS17	-7600.5	7822.5
MRPS18A	-1632.0	6064.0
MRPS18B	8262.0	8890.0
MRPS18C	2306.0	2956.0
MRPS2	5511.0	6971.0
MRPS21	-5796.0	7006.0
MRPS22	-1284.0	2647.0
MRPS23	1447.0	6906.0
MRPS24	8268.0	5944.0
MRPS25	-3030.0	1709.0
MRPS26	-812.0	4995.0
MRPS27	-2570.0	3542.0
MRPS28	8263.0	-1755.0
MRPS30	42.0	7396.0
MRPS31	256.0	3382.0
MRPS33	4225.0	2565.0
MRPS34	-43.0	8171.0
MRPS35	7323.0	-2492.0
MRPS36	-6157.0	-2809.0
MRPS5	-52.0	7980.0
MRPS6	3681.0	6183.0
MRPS7	-140.0	5327.0
MRPS9	3979.0	7008.0
MRRF	-4728.0	3344.0
MTFMT	-3519.0	-5633.0
MTIF2	1057.0	2775.0
MTIF3	4789.0	2023.0
MTRF1L	-6036.0	2943.0
N6AMT1	-4603.0	6206.0
NARS1	7904.0	8630.0
NARS2	7594.0	8507.0
OXA1L	-3990.0	7178.0
PARS2	7234.0	2108.0
PPA1	6963.0	5621.0
PPA2	7765.0	-5688.0
PTCD3	7969.0	8800.0
RARS1	-367.0	1437.0
RARS2	2776.0	4302.0
RPL10A	540.0	4827.0
RPL10L	6226.0	-4646.0
RPL13	-6936.0	5766.0
RPL13A	8662.0	8769.0
RPL15	-5860.0	4087.0
RPL18	2526.0	4846.0
RPL18A	-1925.0	4548.0
RPL19	4213.0	6491.0
RPL21	181.5	45.0
RPL22	5649.0	1761.0
RPL23	-1809.0	3014.0
RPL23A	-6572.0	-7943.0
RPL24	-3019.0	1992.0
RPL27	2645.0	-5667.0
RPL28	-3044.0	6689.0
RPL29	8624.0	6370.0
RPL3	8648.0	-7240.0
RPL30	7077.0	-6538.0
RPL31	5384.0	-1644.0
RPL35	-2959.0	5845.0
RPL35A	-8622.0	-4858.0
RPL36	1102.0	-1619.0
RPL37	7745.0	359.0
RPL37A	1829.0	295.0
RPL38	-5365.0	-4825.0
RPL3L	-6787.0	5079.0
RPL5	3976.0	-4117.0
RPL6	8594.0	-7663.0
RPL7	2882.0	-3180.0
RPL7A	6807.0	-2288.0
RPL8	-3908.0	2263.0
RPL9	4597.0	4414.0
RPLP1	-600.0	-6598.0
RPLP2	6247.0	8473.0
RPN1	-2116.0	1586.0
RPN2	5012.0	6231.0
RPS10	-1770.5	6339.5
RPS11	2070.0	6190.0
RPS13	3415.0	-8357.0
RPS14	5495.0	5365.0
RPS15	5952.0	535.0
RPS15A	8625.0	-4215.0
RPS16	8612.0	-7367.0
RPS17	-1744.0	-7106.0
RPS18	6266.0	-6297.0
RPS19	1867.0	-6360.0
RPS2	-1499.0	-3494.0
RPS21	3740.0	-6563.0
RPS23	6740.0	-2710.0
RPS25	-221.0	-4349.0
RPS26	4910.0	3317.0
RPS27A	7076.0	2193.0
RPS27L	-2849.0	1056.0
RPS28	2906.0	-86.0
RPS3	2452.0	-3227.0
RPS3A	4511.0	126.0
RPS4X	2298.0	4334.0
RPS5	5938.0	1963.0
RPS6	-5452.0	3079.0
RPS7	-1931.0	5162.0
RPS8	3111.0	1095.0
RPS9	-7262.0	7861.0
RPSA	-1325.0	5495.0
SARS1	-5348.0	1659.0
SARS2	-5658.5	3876.5
SEC11A	1644.0	-2938.0
SEC11C	-200.0	5402.0
SEC61A1	6679.0	-2336.0
SEC61A2	-5123.0	-5600.0
SEC61B	2781.0	-5229.0
SEC61G	-2606.0	8052.0
SPCS1	-3681.0	2689.0
SPCS2	1161.0	1192.0
SPCS3	703.0	-3225.0
SRP14	-5415.0	1924.0
SRP19	2724.0	606.0
SRP54	-154.0	-1827.0
SRP68	-3864.0	6022.0
SRP72	5178.0	-7566.0
SRP9	7641.0	1588.0
SRPRA	357.0	3889.0
SRPRB	-780.0	-5597.0
SSR1	-7224.0	-7967.0
SSR2	8097.0	-5033.0
SSR3	3605.0	1743.0
SSR4	5121.0	3488.0
TARS1	7437.0	3698.0
TARS2	-5883.0	5290.0
TRAM1	8055.0	-6456.0
TRMT112	-4378.0	-4723.0
TSFM	-4767.0	7637.0
TUFM	-106.0	7295.0
UBA52	-1940.0	7240.0
VARS1	-4791.0	8791.0
VARS2	-7094.0	8753.0
WARS1	6568.0	7737.0
WARS2	-6764.0	-3139.0
YARS1	917.0	4152.0
YARS2	-936.0	-1237.0

---

---

Mitochondrial translation elongation

Mitochondrial translation elongation

metric	value
setSize	85
pMANOVA	1.13e-21
p.adjustMANOVA	8.16e-19
s.dist	0.611
s.skel	0.174
s.heart	0.585
p.skel	0.00551
p.heart	1.02e-20

Top 20 genes

Gene	skel	heart
MRPS18B	8262	8890
PTCD3	7969	8800
MRPL36	8170	8030
MRPL1	8264	7549
MRPS14	8631	6963
DAP3	7591	6691
MRPS24	8268	5944
MRPL14	6574	7116
MRPL17	6725	6453
MRPL45	5550	7688
MRPL42	5782	7034
MRPS2	5511	6971
MRPL24	5886	5906
MRPL2	6957	4885
MRPL46	4658	6980
MRPL50	5332	5947
MRPL12	3990	7781
MRPS9	3979	7008
MRPL44	3657	7306
MRPL47	4297	6174

Click HERE to show all gene set members

All member genes

	skel	heart
CHCHD1	7269.0	2524.0
DAP3	7591.0	6691.0
ERAL1	-5371.0	2877.0
GADD45GIP1	3684.0	5202.0
GFM1	-5362.0	8253.0
MRPL1	8264.0	7549.0
MRPL10	2998.0	8086.0
MRPL11	3525.0	6331.0
MRPL12	3990.0	7781.0
MRPL13	3516.0	5678.0
MRPL14	6574.0	7116.0
MRPL15	997.0	6964.0
MRPL16	-2084.0	1260.0
MRPL17	6725.0	6453.0
MRPL18	3086.0	2055.0
MRPL19	2255.0	7329.0
MRPL2	6957.0	4885.0
MRPL20	4321.0	4290.0
MRPL21	1036.0	1621.0
MRPL22	4861.0	5203.0
MRPL24	5886.0	5906.0
MRPL27	1882.0	-1669.0
MRPL28	-3666.0	7741.0
MRPL3	3631.0	5677.0
MRPL30	-4228.5	8621.5
MRPL32	3203.0	3553.0
MRPL33	2952.0	6991.0
MRPL34	-4124.0	6893.0
MRPL35	3331.0	4469.0
MRPL36	8170.0	8030.0
MRPL37	-7011.0	8256.0
MRPL38	-3883.0	8264.0
MRPL39	287.0	6476.0
MRPL4	-4539.0	7792.0
MRPL40	5081.0	3168.0
MRPL41	-4190.0	1609.0
MRPL42	5782.0	7034.0
MRPL43	2921.0	-1127.0
MRPL44	3657.0	7306.0
MRPL45	5550.0	7688.0
MRPL46	4658.0	6980.0
MRPL47	4297.0	6174.0
MRPL48	-1052.0	994.0
MRPL49	455.0	5109.0
MRPL50	5332.0	5947.0
MRPL51	-6613.0	1221.0
MRPL52	2389.0	3907.0
MRPL53	459.0	6650.0
MRPL54	338.0	6267.0
MRPL55	611.0	5042.0
MRPL58	-2779.0	7028.0
MRPL9	-1324.0	7335.0
MRPS10	-2447.0	2655.0
MRPS11	-727.0	4948.0
MRPS12	-374.0	4749.0
MRPS14	8631.0	6963.0
MRPS15	-320.0	7601.0
MRPS16	2291.0	-1381.0
MRPS17	-7600.5	7822.5
MRPS18A	-1632.0	6064.0
MRPS18B	8262.0	8890.0
MRPS18C	2306.0	2956.0
MRPS2	5511.0	6971.0
MRPS21	-5796.0	7006.0
MRPS22	-1284.0	2647.0
MRPS23	1447.0	6906.0
MRPS24	8268.0	5944.0
MRPS25	-3030.0	1709.0
MRPS26	-812.0	4995.0
MRPS27	-2570.0	3542.0
MRPS28	8263.0	-1755.0
MRPS30	42.0	7396.0
MRPS31	256.0	3382.0
MRPS33	4225.0	2565.0
MRPS34	-43.0	8171.0
MRPS35	7323.0	-2492.0
MRPS36	-6157.0	-2809.0
MRPS5	-52.0	7980.0
MRPS6	3681.0	6183.0
MRPS7	-140.0	5327.0
MRPS9	3979.0	7008.0
OXA1L	-3990.0	7178.0
PTCD3	7969.0	8800.0
TSFM	-4767.0	7637.0
TUFM	-106.0	7295.0

---

---

Mitochondrial translation

Mitochondrial translation

metric	value
setSize	91
pMANOVA	3.6e-21
p.adjustMANOVA	1.73e-18
s.dist	0.584
s.skel	0.154
s.heart	0.563
p.skel	0.0114
p.heart	1.57e-20

Top 20 genes

Gene	skel	heart
MRPS18B	8262	8890
PTCD3	7969	8800
MRPL36	8170	8030
MRPL1	8264	7549
MRPS14	8631	6963
DAP3	7591	6691
MRPS24	8268	5944
MRPL14	6574	7116
MRPL17	6725	6453
MRPL45	5550	7688
MRPL42	5782	7034
MRPS2	5511	6971
MRPL24	5886	5906
MRPL2	6957	4885
MRPL46	4658	6980
MRPL50	5332	5947
MRPL12	3990	7781
MRPS9	3979	7008
MRPL44	3657	7306
MRPL47	4297	6174

Click HERE to show all gene set members

All member genes

	skel	heart
CHCHD1	7269.0	2524.0
DAP3	7591.0	6691.0
ERAL1	-5371.0	2877.0
GADD45GIP1	3684.0	5202.0
GFM1	-5362.0	8253.0
GFM2	685.0	8246.0
MRPL1	8264.0	7549.0
MRPL10	2998.0	8086.0
MRPL11	3525.0	6331.0
MRPL12	3990.0	7781.0
MRPL13	3516.0	5678.0
MRPL14	6574.0	7116.0
MRPL15	997.0	6964.0
MRPL16	-2084.0	1260.0
MRPL17	6725.0	6453.0
MRPL18	3086.0	2055.0
MRPL19	2255.0	7329.0
MRPL2	6957.0	4885.0
MRPL20	4321.0	4290.0
MRPL21	1036.0	1621.0
MRPL22	4861.0	5203.0
MRPL24	5886.0	5906.0
MRPL27	1882.0	-1669.0
MRPL28	-3666.0	7741.0
MRPL3	3631.0	5677.0
MRPL30	-4228.5	8621.5
MRPL32	3203.0	3553.0
MRPL33	2952.0	6991.0
MRPL34	-4124.0	6893.0
MRPL35	3331.0	4469.0
MRPL36	8170.0	8030.0
MRPL37	-7011.0	8256.0
MRPL38	-3883.0	8264.0
MRPL39	287.0	6476.0
MRPL4	-4539.0	7792.0
MRPL40	5081.0	3168.0
MRPL41	-4190.0	1609.0
MRPL42	5782.0	7034.0
MRPL43	2921.0	-1127.0
MRPL44	3657.0	7306.0
MRPL45	5550.0	7688.0
MRPL46	4658.0	6980.0
MRPL47	4297.0	6174.0
MRPL48	-1052.0	994.0
MRPL49	455.0	5109.0
MRPL50	5332.0	5947.0
MRPL51	-6613.0	1221.0
MRPL52	2389.0	3907.0
MRPL53	459.0	6650.0
MRPL54	338.0	6267.0
MRPL55	611.0	5042.0
MRPL58	-2779.0	7028.0
MRPL9	-1324.0	7335.0
MRPS10	-2447.0	2655.0
MRPS11	-727.0	4948.0
MRPS12	-374.0	4749.0
MRPS14	8631.0	6963.0
MRPS15	-320.0	7601.0
MRPS16	2291.0	-1381.0
MRPS17	-7600.5	7822.5
MRPS18A	-1632.0	6064.0
MRPS18B	8262.0	8890.0
MRPS18C	2306.0	2956.0
MRPS2	5511.0	6971.0
MRPS21	-5796.0	7006.0
MRPS22	-1284.0	2647.0
MRPS23	1447.0	6906.0
MRPS24	8268.0	5944.0
MRPS25	-3030.0	1709.0
MRPS26	-812.0	4995.0
MRPS27	-2570.0	3542.0
MRPS28	8263.0	-1755.0
MRPS30	42.0	7396.0
MRPS31	256.0	3382.0
MRPS33	4225.0	2565.0
MRPS34	-43.0	8171.0
MRPS35	7323.0	-2492.0
MRPS36	-6157.0	-2809.0
MRPS5	-52.0	7980.0
MRPS6	3681.0	6183.0
MRPS7	-140.0	5327.0
MRPS9	3979.0	7008.0
MRRF	-4728.0	3344.0
MTFMT	-3519.0	-5633.0
MTIF2	1057.0	2775.0
MTIF3	4789.0	2023.0
MTRF1L	-6036.0	2943.0
OXA1L	-3990.0	7178.0
PTCD3	7969.0	8800.0
TSFM	-4767.0	7637.0
TUFM	-106.0	7295.0

---

---

Mitochondrial translation termination

Mitochondrial translation termination

metric	value
setSize	85
pMANOVA	6.43e-21
p.adjustMANOVA	2.32e-18
s.dist	0.6
s.skel	0.174
s.heart	0.574
p.skel	0.00546
p.heart	5.85e-20

Top 20 genes

Gene	skel	heart
MRPS18B	8262	8890
PTCD3	7969	8800
MRPL36	8170	8030
MRPL1	8264	7549
MRPS14	8631	6963
DAP3	7591	6691
MRPS24	8268	5944
MRPL14	6574	7116
MRPL17	6725	6453
MRPL45	5550	7688
MRPL42	5782	7034
MRPS2	5511	6971
MRPL24	5886	5906
MRPL2	6957	4885
MRPL46	4658	6980
MRPL50	5332	5947
MRPL12	3990	7781
MRPS9	3979	7008
MRPL44	3657	7306
MRPL47	4297	6174

Click HERE to show all gene set members

All member genes

	skel	heart
CHCHD1	7269.0	2524.0
DAP3	7591.0	6691.0
ERAL1	-5371.0	2877.0
GADD45GIP1	3684.0	5202.0
GFM2	685.0	8246.0
MRPL1	8264.0	7549.0
MRPL10	2998.0	8086.0
MRPL11	3525.0	6331.0
MRPL12	3990.0	7781.0
MRPL13	3516.0	5678.0
MRPL14	6574.0	7116.0
MRPL15	997.0	6964.0
MRPL16	-2084.0	1260.0
MRPL17	6725.0	6453.0
MRPL18	3086.0	2055.0
MRPL19	2255.0	7329.0
MRPL2	6957.0	4885.0
MRPL20	4321.0	4290.0
MRPL21	1036.0	1621.0
MRPL22	4861.0	5203.0
MRPL24	5886.0	5906.0
MRPL27	1882.0	-1669.0
MRPL28	-3666.0	7741.0
MRPL3	3631.0	5677.0
MRPL30	-4228.5	8621.5
MRPL32	3203.0	3553.0
MRPL33	2952.0	6991.0
MRPL34	-4124.0	6893.0
MRPL35	3331.0	4469.0
MRPL36	8170.0	8030.0
MRPL37	-7011.0	8256.0
MRPL38	-3883.0	8264.0
MRPL39	287.0	6476.0
MRPL4	-4539.0	7792.0
MRPL40	5081.0	3168.0
MRPL41	-4190.0	1609.0
MRPL42	5782.0	7034.0
MRPL43	2921.0	-1127.0
MRPL44	3657.0	7306.0
MRPL45	5550.0	7688.0
MRPL46	4658.0	6980.0
MRPL47	4297.0	6174.0
MRPL48	-1052.0	994.0
MRPL49	455.0	5109.0
MRPL50	5332.0	5947.0
MRPL51	-6613.0	1221.0
MRPL52	2389.0	3907.0
MRPL53	459.0	6650.0
MRPL54	338.0	6267.0
MRPL55	611.0	5042.0
MRPL58	-2779.0	7028.0
MRPL9	-1324.0	7335.0
MRPS10	-2447.0	2655.0
MRPS11	-727.0	4948.0
MRPS12	-374.0	4749.0
MRPS14	8631.0	6963.0
MRPS15	-320.0	7601.0
MRPS16	2291.0	-1381.0
MRPS17	-7600.5	7822.5
MRPS18A	-1632.0	6064.0
MRPS18B	8262.0	8890.0
MRPS18C	2306.0	2956.0
MRPS2	5511.0	6971.0
MRPS21	-5796.0	7006.0
MRPS22	-1284.0	2647.0
MRPS23	1447.0	6906.0
MRPS24	8268.0	5944.0
MRPS25	-3030.0	1709.0
MRPS26	-812.0	4995.0
MRPS27	-2570.0	3542.0
MRPS28	8263.0	-1755.0
MRPS30	42.0	7396.0
MRPS31	256.0	3382.0
MRPS33	4225.0	2565.0
MRPS34	-43.0	8171.0
MRPS35	7323.0	-2492.0
MRPS36	-6157.0	-2809.0
MRPS5	-52.0	7980.0
MRPS6	3681.0	6183.0
MRPS7	-140.0	5327.0
MRPS9	3979.0	7008.0
MRRF	-4728.0	3344.0
MTRF1L	-6036.0	2943.0
OXA1L	-3990.0	7178.0
PTCD3	7969.0	8800.0

---

---

Mitochondrial translation initiation

Mitochondrial translation initiation

metric	value
setSize	85
pMANOVA	5.6e-20
p.adjustMANOVA	1.61e-17
s.dist	0.585
s.skel	0.191
s.heart	0.553
p.skel	0.00232
p.heart	1.2e-18

Top 20 genes

Gene	skel	heart
MRPS18B	8262	8890
PTCD3	7969	8800
MRPL36	8170	8030
MRPL1	8264	7549
MRPS14	8631	6963
DAP3	7591	6691
MRPS24	8268	5944
MRPL14	6574	7116
MRPL17	6725	6453
MRPL45	5550	7688
MRPL42	5782	7034
MRPS2	5511	6971
MRPL24	5886	5906
MRPL2	6957	4885
MRPL46	4658	6980
MRPL50	5332	5947
MRPL12	3990	7781
MRPS9	3979	7008
MRPL44	3657	7306
MRPL47	4297	6174

Click HERE to show all gene set members

All member genes

	skel	heart
CHCHD1	7269.0	2524.0
DAP3	7591.0	6691.0
ERAL1	-5371.0	2877.0
GADD45GIP1	3684.0	5202.0
MRPL1	8264.0	7549.0
MRPL10	2998.0	8086.0
MRPL11	3525.0	6331.0
MRPL12	3990.0	7781.0
MRPL13	3516.0	5678.0
MRPL14	6574.0	7116.0
MRPL15	997.0	6964.0
MRPL16	-2084.0	1260.0
MRPL17	6725.0	6453.0
MRPL18	3086.0	2055.0
MRPL19	2255.0	7329.0
MRPL2	6957.0	4885.0
MRPL20	4321.0	4290.0
MRPL21	1036.0	1621.0
MRPL22	4861.0	5203.0
MRPL24	5886.0	5906.0
MRPL27	1882.0	-1669.0
MRPL28	-3666.0	7741.0
MRPL3	3631.0	5677.0
MRPL30	-4228.5	8621.5
MRPL32	3203.0	3553.0
MRPL33	2952.0	6991.0
MRPL34	-4124.0	6893.0
MRPL35	3331.0	4469.0
MRPL36	8170.0	8030.0
MRPL37	-7011.0	8256.0
MRPL38	-3883.0	8264.0
MRPL39	287.0	6476.0
MRPL4	-4539.0	7792.0
MRPL40	5081.0	3168.0
MRPL41	-4190.0	1609.0
MRPL42	5782.0	7034.0
MRPL43	2921.0	-1127.0
MRPL44	3657.0	7306.0
MRPL45	5550.0	7688.0
MRPL46	4658.0	6980.0
MRPL47	4297.0	6174.0
MRPL48	-1052.0	994.0
MRPL49	455.0	5109.0
MRPL50	5332.0	5947.0
MRPL51	-6613.0	1221.0
MRPL52	2389.0	3907.0
MRPL53	459.0	6650.0
MRPL54	338.0	6267.0
MRPL55	611.0	5042.0
MRPL58	-2779.0	7028.0
MRPL9	-1324.0	7335.0
MRPS10	-2447.0	2655.0
MRPS11	-727.0	4948.0
MRPS12	-374.0	4749.0
MRPS14	8631.0	6963.0
MRPS15	-320.0	7601.0
MRPS16	2291.0	-1381.0
MRPS17	-7600.5	7822.5
MRPS18A	-1632.0	6064.0
MRPS18B	8262.0	8890.0
MRPS18C	2306.0	2956.0
MRPS2	5511.0	6971.0
MRPS21	-5796.0	7006.0
MRPS22	-1284.0	2647.0
MRPS23	1447.0	6906.0
MRPS24	8268.0	5944.0
MRPS25	-3030.0	1709.0
MRPS26	-812.0	4995.0
MRPS27	-2570.0	3542.0
MRPS28	8263.0	-1755.0
MRPS30	42.0	7396.0
MRPS31	256.0	3382.0
MRPS33	4225.0	2565.0
MRPS34	-43.0	8171.0
MRPS35	7323.0	-2492.0
MRPS36	-6157.0	-2809.0
MRPS5	-52.0	7980.0
MRPS6	3681.0	6183.0
MRPS7	-140.0	5327.0
MRPS9	3979.0	7008.0
MTFMT	-3519.0	-5633.0
MTIF2	1057.0	2775.0
MTIF3	4789.0	2023.0
OXA1L	-3990.0	7178.0
PTCD3	7969.0	8800.0

---

---

The citric acid (TCA) cycle and respiratory electron transport

The citric acid (TCA) cycle and respiratory electron transport

metric	value
setSize	164
pMANOVA	6.83e-13
p.adjustMANOVA	1.64e-10
s.dist	0.336
s.skel	0.081
s.heart	0.326
p.skel	0.0737
p.heart	5.49e-13

Top 20 genes

Gene	skel	heart
ACAD9	7631.0	7946.0
PDHX	6673.0	8447.0
FAHD1	6514.0	7880.0
NDUFA8	5987.0	8490.0
BSG	6138.0	8069.0
NDUFA2	7987.0	5613.0
COX11	5457.0	7979.0
DLAT	6055.0	6731.0
MPC1	7100.0	5720.0
ME3	4563.0	7888.0
NDUFA6	5924.0	5771.0
PDHB	4035.0	8121.0
TIMMDC1	4421.0	7069.0
NDUFAB1	6473.0	4242.0
HAGH	3972.0	6673.0
COX18	5469.0	4656.0
NDUFB9	4566.0	5421.0
DMAC2L	4240.0	5813.0
MPC2	5072.0	4734.0
NDUFA7	5691.5	3873.5

Click HERE to show all gene set members

All member genes

	skel	heart
ACAD9	7631.0	7946.0
ACO2	769.0	8700.0
ADHFE1	-4253.0	6327.0
ATP5F1A	-1377.0	-5931.0
ATP5F1B	-1494.0	4951.0
ATP5F1D	-704.0	8523.0
ATP5F1E	5050.0	-1368.0
ATP5MC3	3773.0	312.0
ATP5ME	-4161.0	-3064.0
ATP5MF	2482.0	2566.0
ATP5MG	1185.5	-2613.5
ATP5PB	-6172.0	8413.0
ATP5PD	-68.0	3308.0
ATP5PF	-1793.0	-399.0
ATP5PO	2969.5	2847.5
BSG	6138.0	8069.0
COQ10A	-6941.0	-2064.0
COQ10B	-149.0	2833.0
COX11	5457.0	7979.0
COX14	2222.0	3423.0
COX16	-1973.0	-7786.0
COX18	5469.0	4656.0
COX19	-2652.0	-1153.0
COX20	2493.0	669.0
COX4I1	2872.0	3827.0
COX5A	3962.0	473.0
COX5B	-1445.0	5794.0
COX6A1	844.0	1034.0
COX6B1	2433.0	-5248.0
COX7A2L	-4533.0	6293.0
COX7B	4671.0	2669.0
COX7C	4843.0	-2111.0
COX8A	2020.0	-4946.0
CS	1762.0	5778.0
CYC1	1643.0	5325.0
D2HGDH	-5292.0	520.0
DLAT	6055.0	6731.0
DLD	3620.0	2901.0
DLST	2103.0	7989.0
DMAC2L	4240.0	5813.0
ECSIT	-2263.0	8037.0
ETFA	3199.0	5540.0
ETFB	-2415.0	6029.0
ETFDH	-352.0	7165.0
FAHD1	6514.0	7880.0
FH	-2698.0	6352.0
GLO1	1342.0	1240.0
GSTZ1	-8419.0	-7748.0
HAGH	3972.0	6673.0
IDH2	-6791.0	7310.0
IDH3A	-64.0	7065.0
IDH3B	434.0	6615.0
IDH3G	-2889.0	2505.0
L2HGDH	4426.0	4326.0
LDHA	-3338.0	1521.0
LDHB	-415.5	7317.5
LDHC	-7316.0	7296.0
MDH2	-3909.0	1091.0
ME1	591.0	-80.0
ME2	2166.0	9.0
ME3	4563.0	7888.0
MPC1	7100.0	5720.0
MPC2	5072.0	4734.0
MT-ATP6	-2757.0	1204.0
MT-ATP8	-2853.0	-4774.0
MT-CO1	-2993.0	7342.0
MT-CO2	-2478.0	6828.0
MT-CO3	2221.0	1527.0
MT-CYB	-2903.0	1337.0
MT-ND1	-3770.0	2451.0
MT-ND2	-783.0	299.0
MT-ND3	-3514.0	1797.0
MT-ND4	-3963.0	382.0
MT-ND5	-4600.0	1285.0
MT-ND6	-4778.0	-754.0
NDUFA1	7797.0	-3580.0
NDUFA10	-377.0	5987.0
NDUFA11	662.5	4964.5
NDUFA12	1609.0	8560.0
NDUFA13	-81.0	7199.0
NDUFA2	7987.0	5613.0
NDUFA3	2870.0	2229.0
NDUFA4	3762.0	1226.0
NDUFA5	676.0	3420.0
NDUFA6	5924.0	5771.0
NDUFA7	5691.5	3873.5
NDUFA8	5987.0	8490.0
NDUFA9	1104.0	3610.0
NDUFAB1	6473.0	4242.0
NDUFAF1	-2181.0	2883.0
NDUFAF3	-2409.0	6988.0
NDUFAF4	125.0	6668.0
NDUFAF5	-2715.0	1947.0
NDUFAF6	-2930.0	-2683.0
NDUFAF7	7863.0	2760.0
NDUFB10	-1877.0	6302.0
NDUFB11	7357.0	-361.0
NDUFB2	-2642.0	4479.0
NDUFB3	7684.0	-3453.0
NDUFB4	-7278.0	-3860.0
NDUFB5	3542.0	1027.0
NDUFB6	3414.0	3235.0
NDUFB7	-2445.0	2370.0
NDUFB8	2773.5	4506.5
NDUFB9	4566.0	5421.0
NDUFC1	6283.0	3026.0
NDUFC2	781.5	2587.5
NDUFS1	119.0	2981.0
NDUFS2	-1004.0	6854.0
NDUFS3	2309.0	6202.0
NDUFS4	4055.0	2334.0
NDUFS5	-2600.0	8309.0
NDUFS6	7811.0	-2761.0
NDUFS7	-2856.0	7757.0
NDUFS8	2854.0	5403.0
NDUFV1	-133.0	6803.0
NDUFV2	3291.0	6011.0
NDUFV3	8473.0	-6717.0
NNT	-231.0	772.0
NUBPL	4558.0	-1135.0
OGDH	-5740.0	4362.0
PDHA1	-1572.0	6522.0
PDHB	4035.0	8121.0
PDHX	6673.0	8447.0
PDK1	-2244.0	4071.0
PDK2	-5697.0	7102.0
PDK3	-21.0	-6639.0
PDK4	-5726.0	-493.0
PDP1	-7819.0	8521.0
PDP2	3218.0	2237.0
PDPR	3181.0	6000.0
PM20D1	-6192.0	-7588.0
PPARD	-6659.0	2423.0
RXRA	-4958.0	387.0
SCO1	-1140.0	6877.0
SDHA	-1653.5	4126.5
SDHB	1308.0	6790.0
SDHC	1049.0	4498.0
SDHD	-257.5	2208.5
SLC16A1	1474.0	-367.0
SLC16A3	2487.0	-369.0
SLC16A8	1819.0	-5156.0
SLC25A14	6828.0	-4482.0
SLC25A27	6049.0	3632.0
SUCLA2	-2280.0	3175.0
SUCLG1	4086.0	3231.0
SUCLG2	-4818.0	-229.0
SURF1	818.0	5283.0
TACO1	1469.0	7286.0
TIMMDC1	4421.0	7069.0
TMEM126B	2822.0	-2468.0
TRAP1	-3817.0	7194.0
UCP1	2158.0	-356.0
UCP2	-6256.0	3987.0
UCP3	-1127.0	-4919.0
UQCR10	5657.0	3744.0
UQCR11	-3327.5	2636.5
UQCRB	7471.0	-7671.0
UQCRC1	-746.0	6208.0
UQCRC2	686.0	3409.0
UQCRFS1	-512.0	6119.0
UQCRH	2930.5	4859.5
UQCRQ	3103.0	4519.0
VDAC1	-3136.0	4155.0

---

---

Macroautophagy

Macroautophagy

metric	value
setSize	108
pMANOVA	4.64e-11
p.adjustMANOVA	9.56e-09
s.dist	0.384
s.skel	-0.0126
s.heart	0.384
p.skel	0.821
p.heart	5.26e-12

Top 20 genes

Gene	skel	heart
CSNK2B	-8515.0	8824.0
PARK7	-8340.0	8811.0
TSC2	-8065.0	8707.0
IFT88	-7980.0	8627.0
MAP1LC3B	-8153.5	8186.5
MTMR3	-7905.0	8298.0
PINK1	-7552.0	8397.0
NBR1	-7939.0	7413.0
MFN2	-6960.0	8451.0
USP30	-7166.0	7213.0
SQSTM1	-5057.0	8580.0
ATG4B	-5760.0	7380.0
GABARAPL1	-7525.0	5491.0
ATG5	-7194.0	5130.0
PRKAB1	-6055.0	5660.0
CHMP6	-7417.0	4546.0
WIPI2	-4838.0	6505.0
HDAC6	-6881.0	4275.0
DYNC1I2	-5706.0	5083.0
ATG9A	-5830.0	4522.0

Click HERE to show all gene set members

All member genes

	skel	heart
AMBRA1	-8497.0	-2866.0
ARL13B	7232.0	8489.0
ATG10	-1336.0	7618.0
ATG101	8063.0	6483.0
ATG12	2688.0	5077.0
ATG13	2170.0	2128.0
ATG14	679.0	-1285.0
ATG16L1	8400.0	8420.0
ATG3	6778.0	-7870.0
ATG4A	-255.0	3092.0
ATG4B	-5760.0	7380.0
ATG4C	5981.0	4403.0
ATG4D	7814.0	7731.0
ATG5	-7194.0	5130.0
ATG7	2503.0	-150.0
ATG9A	-5830.0	4522.0
ATG9B	7405.0	-3330.0
ATM	8167.0	-4787.0
BECN1	-5333.0	-7409.0
CETN1	1909.0	-2349.0
CFTR	1846.0	333.0
CHMP2A	-2015.0	153.0
CHMP2B	2625.0	5382.0
CHMP3	1021.5	5988.5
CHMP4B	-4052.0	4975.0
CHMP4C	4158.0	5907.0
CHMP6	-7417.0	4546.0
CHMP7	7382.0	7804.0
CSNK2A1	1817.5	4970.5
CSNK2A2	-5978.0	-4520.0
CSNK2B	-8515.0	8824.0
DYNC1H1	7671.0	6805.0
DYNC1I1	5105.0	2652.0
DYNC1I2	-5706.0	5083.0
DYNC1LI1	6461.0	7025.0
DYNC1LI2	4553.0	-2293.0
DYNLL1	1967.0	754.0
DYNLL2	-3336.0	6037.0
EPAS1	-6815.0	3574.0
FUNDC1	5940.0	1799.0
GABARAP	4917.0	3037.0
GABARAPL1	-7525.0	5491.0
GABARAPL2	3303.0	491.0
HDAC6	-6881.0	4275.0
HSF1	-3651.0	1899.0
HSPA8	382.0	7793.0
IFT88	-7980.0	8627.0
LAMTOR1	1538.0	5698.0
LAMTOR2	6759.0	7981.0
LAMTOR3	2898.0	3567.0
LAMTOR4	6737.0	5739.0
LAMTOR5	-7085.0	-1730.0
MAP1LC3A	4067.0	5098.0
MAP1LC3B	-8153.5	8186.5
MFN1	6282.0	7683.0
MFN2	-6960.0	8451.0
MLST8	-3215.0	524.0
MTERF3	-5797.0	-1900.0
MTMR14	-1824.0	6421.0
MTMR3	-7905.0	8298.0
MTOR	3277.0	8262.0
NBR1	-7939.0	7413.0
PARK7	-8340.0	8811.0
PCNT	-6585.0	2600.0
PEX5	4433.0	-256.0
PGAM5	2963.0	139.0
PIK3C3	5209.0	7133.0
PIK3R4	3914.0	1845.0
PINK1	-7552.0	8397.0
PLIN2	-803.0	6441.0
PLIN3	-626.0	7418.0
PRKAA1	3192.0	-7129.0
PRKAA2	4171.0	6123.0
PRKAB1	-6055.0	5660.0
PRKAB2	-128.0	8793.0
PRKAG2	-1682.0	-732.0
PRKAG3	-3862.0	2949.0
RB1CC1	6316.0	-749.0
RHEB	3445.0	4542.0
RPS27A	7076.0	2193.0
RPTOR	-5074.0	5182.0
RRAGA	1911.0	1066.0
RRAGB	-4446.0	-2305.0
RRAGC	3850.0	4236.0
RRAGD	858.0	2887.0
SLC38A9	6349.0	-6219.0
SQSTM1	-5057.0	8580.0
SRC	-7820.0	-2286.0
TOMM20	15.0	3071.0
TOMM22	3929.0	2851.0
TOMM40	1301.0	8216.0
TOMM6	1744.0	6131.0
TOMM7	1025.0	-4848.0
TOMM70	2750.0	2724.0
TSC1	-5152.0	1619.0
TSC2	-8065.0	8707.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
UBE2N	3842.5	3787.5
ULK1	-3344.0	450.0
USP30	-7166.0	7213.0
UVRAG	3216.0	-5061.0
VCP	-3107.0	6482.0
VDAC1	-3136.0	4155.0
WDR45	309.0	6499.0
WDR45B	3755.0	2661.0
WIPI1	-1415.0	6516.0
WIPI2	-4838.0	6505.0

---

---

Metabolism of proteins

Metabolism of proteins

metric	value
setSize	1803
pMANOVA	1.01e-10
p.adjustMANOVA	1.83e-08
s.dist	0.0965
s.skel	0.0297
s.heart	0.0918
p.skel	0.0386
p.heart	1.58e-10

Top 20 genes

Gene	skel	heart
ADAMTSL1	8570	8884
RPL13A	8662	8769
MIA2	8537	8875
MRPS18B	8262	8890
NEU1	8466	8608
SPTAN1	8260	8609
SELENOS	8432	8426
RHOT1	8437	8316
PTCD3	7969	8800
LMNA	8469	8154
NARS1	7904	8630
PRMT3	7810	8415
MRPL36	8170	8030
FBXL19	7441	8682
NARS2	7594	8507
PSMB8	7349	8633
MAT2B	7935	7964
MRPL1	8264	7549
MARS2	7803	7855
NUP58	8481	7137

Click HERE to show all gene set members

All member genes

	skel	heart
AAAS	-438.0	7079.0
AARS1	-4806.0	7803.0
AARS2	-6223.0	5546.0
ABCA3	-3896.0	2176.0
ACADVL	2074.0	6681.0
ACE	-7533.0	-4828.0
ACE2	1171.0	-2630.0
ACHE	-8693.0	-2707.0
ACTB	-5345.0	-7961.0
ACTL6A	7067.0	-1151.0
ACTR10	-1328.0	1544.0
ACTR1A	4077.0	6626.0
ACTR5	5736.0	-1883.0
ACTR8	-1958.0	7884.0
ADAM10	-5138.0	2105.0
ADAMTS1	2907.0	1813.0
ADAMTS10	5080.0	3808.0
ADAMTS12	2417.0	-6176.0
ADAMTS13	1592.0	-4149.0
ADAMTS14	4506.0	-8449.0
ADAMTS15	-6390.0	4068.0
ADAMTS16	3213.0	460.0
ADAMTS17	-6608.0	-7109.0
ADAMTS18	1372.0	-5440.0
ADAMTS19	-964.0	-6051.0
ADAMTS2	7792.0	-7360.0
ADAMTS20	-8088.0	7215.0
ADAMTS3	7115.0	-3699.0
ADAMTS4	-4813.0	-6757.0
ADAMTS5	3419.0	-6165.0
ADAMTS6	8388.0	-5496.0
ADAMTS7	-7554.0	6031.0
ADAMTS8	5964.0	-438.0
ADAMTS9	3483.0	96.0
ADAMTSL1	8570.0	8884.0
ADAMTSL2	-5200.0	1079.0
ADAMTSL3	7493.0	-193.0
ADAMTSL4	-2860.0	3176.0
ADAMTSL5	1461.0	5818.0
ADD1	5600.0	406.0
ADGRF5	-4705.0	5090.0
ADORA2A	-2406.0	6044.0
ADORA2B	-7264.0	4410.0
ADRA2A	4300.0	3775.0
ADRA2C	4641.0	4450.0
ADRB2	2580.0	-3113.0
ADRM1	-1093.0	4794.0
AFP	1765.0	-2807.0
AGBL1	7601.0	7110.0
AGBL2	-2080.0	-540.0
AGBL3	5464.0	-5182.0
AGBL4	-867.5	-2449.0
AGBL5	-3118.0	-859.0
AGT	-7588.0	-5820.0
AGTPBP1	-4895.0	3691.0
AHSG	1288.0	-8287.0
AIMP1	5901.0	2626.0
AIMP2	2900.0	7129.0
ALB	7676.0	-6428.0
ALG1	6467.0	-4514.0
ALG10	-2782.5	-1089.5
ALG10B	-2782.5	-1089.5
ALG11	-2007.0	-5154.0
ALG12	-2151.0	6223.0
ALG14	-46.0	-1702.0
ALG2	5748.0	-3339.0
ALG3	6843.0	8772.0
ALG5	6612.0	445.0
ALG6	-6638.0	-975.0
ALG8	5136.0	-4378.0
ALG9	5606.5	-7255.5
ALPG	-3249.0	-8109.0
ALPI	-3249.0	-8109.0
ALPL	2210.0	-5153.0
AMBN	-2521.0	-5877.0
AMDHD2	-4060.5	1263.5
AMELX	7687.0	-8563.0
AMFR	-4524.0	6200.0
AMTN	439.0	-1621.0
ANK1	-4917.0	6972.0
ANK2	1044.0	8896.0
ANK3	-8694.0	8058.0
ANKRD28	2189.0	-2039.0
ANKRD9	1960.0	7528.0
ANO8	-3140.0	-1055.0
ANPEP	-5568.0	-8000.0
AOPEP	7110.0	4370.0
AP3M1	-3491.0	2466.0
APC	2379.0	4185.0
APCS	1271.0	-370.0
APEH	1324.0	3376.0
APH1A	925.0	5310.0
APH1B	-6117.0	-8489.0
APLP2	-7029.0	5466.0
APOA1	-488.0	3512.0
APOA2	-7127.0	-5091.0
APOA4	-6487.0	-3735.0
APOA5	-8191.0	507.0
APOB	446.0	-8252.0
APOE	-8560.0	-6177.0
APOL1	7144.5	5550.5
APP	7187.0	7687.0
AR	3529.0	-1894.0
ARCN1	1551.0	-4564.0
AREG	-235.0	-3597.0
ARF1	-6136.0	5121.0
ARF4	7149.0	-2214.0
ARF5	4230.0	5227.0
ARFGAP1	-3708.0	-3942.0
ARFGAP2	-4929.0	3842.0
ARFGAP3	4667.0	724.0
ARFGEF2	3494.0	5761.0
ARL2	6164.0	8234.0
ARRB1	-23.0	757.0
ARRB2	-6483.0	-1323.0
ARSA	-4926.0	2825.0
ARSB	566.0	-4573.0
ARSG	21.0	-1189.0
ARSI	6330.0	-5272.0
ARSK	-1160.0	-1712.0
ARSL	3149.0	596.0
ART3	141.0	7707.0
ART4	-7762.0	488.0
ASB1	2555.0	6995.0
ASB10	-4608.0	7367.0
ASB12	-8569.0	7221.0
ASB13	5287.0	1425.0
ASB14	-7577.0	1653.0
ASB15	-4611.0	-325.0
ASB16	-6571.0	-8037.0
ASB17	2499.0	2988.0
ASB18	-5247.0	1398.0
ASB2	-2539.0	5531.0
ASB3	6492.0	-7513.0
ASB4	-3199.0	-7297.0
ASB5	1383.0	5416.0
ASB6	-2519.0	6724.0
ASB7	7668.0	-1627.0
ASB8	-8482.0	5012.0
ASB9	-6875.0	7614.0
ASGR1	2810.0	-2459.0
ASGR2	-8266.0	-8112.0
ASNS	7343.0	6787.0
ASXL1	1897.0	-4098.0
ASXL2	-217.0	-950.0
ATF3	-7168.0	7522.0
ATF4	6425.0	7657.0
ATF6	-4340.0	-2594.0
ATP6AP2	-1459.0	213.0
ATP6V0D1	-8135.0	8376.0
ATXN3	3992.5	5841.5
ATXN3L	3992.5	5841.5
ATXN7	-3828.0	-148.0
AURKA	-4639.0	-943.0
AURKB	3785.0	-7079.0
AXIN2	-7250.0	3971.0
B2M	1730.0	5055.0
B3GALNT2	-6341.0	4741.0
B3GLCT	-3429.0	-3006.0
B3GNT2	-2195.0	-6605.0
B3GNT3	8057.0	-473.0
B3GNT4	3532.0	4961.0
B3GNT5	4110.0	3200.0
B3GNT6	-4661.0	4402.0
B3GNT7	-5577.0	-5188.0
B3GNT8	-7078.0	-798.0
B3GNT9	-1436.0	-4985.0
B3GNTL1	-1897.0	2674.0
B4GALT1	-2811.0	-4650.0
B4GALT2	5032.0	-1463.0
B4GALT3	-1947.0	2598.0
B4GALT4	2234.0	-6309.0
B4GALT5	4188.0	8099.0
B4GALT6	8566.0	-7661.0
B4GAT1	-3827.0	-2685.0
BABAM1	-4096.0	3462.0
BACE1	-2888.0	2091.0
BAP1	-5776.0	6454.0
BARD1	4647.0	376.0
BCHE	-5321.0	-3661.0
BCL10	539.0	-1425.0
BECN1	-5333.0	-7409.0
BET1L	6614.0	4581.0
BGLAP	2040.0	6060.0
BIRC2	-5080.0	231.0
BIRC3	7622.0	-7584.0
BIRC5	897.0	-6910.0
BLM	1319.0	-7706.0
BMI1	2356.5	6662.5
BMP15	-3321.0	-4208.0
BMP4	3908.0	-5892.0
BRCA1	6848.0	-6073.0
BRCC3	2462.0	-2304.0
BST1	5015.0	-2795.0
BTBD1	1659.0	6107.0
BTBD6	7235.0	549.0
BTRC	5925.0	-1783.0
C1GALT1	7311.0	-8233.0
C1GALT1C1	6360.0	-480.0
C3	-6034.0	-8192.0
C4A	-8769.5	7476.5
CALB1	6222.0	518.0
CALCA	4552.0	-7312.0
CALM1	-82.0	3278.0
CALR	5354.0	4308.0
CALU	-3850.0	8564.0
CAMKMT	2648.0	-7900.0
CAND1	7260.0	-4407.0
CANX	-3957.0	6648.0
CAPZA2	5077.0	983.0
CAPZA3	-275.0	-1499.0
CAPZB	-6599.0	7257.0
CARS1	4522.0	4053.0
CARS2	-8348.0	1141.0
CASP8AP2	7546.0	-3379.0
CBX2	-1491.0	3384.0
CBX4	636.0	6536.0
CBX5	6422.0	2235.0
CBX8	1467.0	6721.0
CCDC22	-1765.0	-830.0
CCDC59	5658.0	4415.0
CCDC8	-3242.0	2167.0
CCL2	-2395.0	456.0
CCNA1	4273.0	-7006.0
CCNA2	-6375.0	-7393.0
CCNE1	-5323.0	3494.0
CCNE2	4508.0	-6020.0
CCNF	-4532.0	-6770.0
CCP110	5409.0	-192.0
CCT2	2459.0	3164.0
CCT3	-8691.0	8355.0
CCT4	-132.0	3335.0
CCT5	-1040.0	4330.0
CCT6A	-4005.0	6958.0
CCT6B	3150.0	-1840.0
CCT7	-2590.0	6353.0
CCT8	1676.0	4017.0
CD109	5231.0	-7638.0
CD52	602.0	-1844.0
CD55	-2975.0	4811.0
CD59	-2355.5	5197.5
CDC20	-7220.0	-8234.0
CDC25A	-457.0	-1553.0
CDC34	-2234.0	8209.0
CDC73	5049.0	-4094.0
CDCA8	2908.0	-4539.0
CDH2	5300.0	-3581.0
CDK1	-7804.0	-8477.0
CDX2	-1377.0	1560.5
CEACAM5	-4145.5	-8052.5
CEACAM7	-4145.5	-8052.5
CEBPB	-2155.0	-364.0
CEBPG	6655.0	1510.0
CES1	-8429.0	921.0
CETN2	-1076.0	118.0
CFP	-3673.0	720.0
CFTR	1846.0	333.0
CGA	-260.5	810.5
CHCHD1	7269.0	2524.0
CHD3	-5320.0	-5388.0
CHGB	3224.0	-2117.0
CHM	-7930.0	7833.0
CHRDL1	7007.0	2265.0
CHST10	6824.0	-3468.0
CHST4	-4585.0	-4609.0
CHST8	-2051.0	-3202.0
CISH	2507.0	-1338.0
CKAP4	4908.0	-4121.0
CLSPN	-92.0	-8254.0
CLTRN	-7835.5	-2553.5
CMA1	6124.0	-3362.0
CMAS	2725.0	2807.0
CNIH1	-6217.0	3921.0
CNIH2	1280.0	447.0
CNIH3	1006.0	7836.0
CNTN3	3711.0	2961.0
CNTN4	-6996.0	-6222.0
CNTN5	-339.0	-13.0
COG1	-7083.0	7572.0
COG2	7682.0	4313.0
COG3	5426.0	1059.0
COG4	-1782.0	8165.0
COG5	-6999.0	4726.0
COG6	4599.0	-4875.0
COG7	8151.0	4747.0
COMMD1	-7370.0	2696.0
COMMD10	1216.0	-6619.0
COMMD2	-2094.0	461.0
COMMD3	11.0	4763.0
COMMD4	-1213.0	8313.0
COMMD5	3883.0	5125.0
COMMD6	5673.0	-3983.0
COMMD7	2367.5	2967.5
COMMD8	-6009.0	1876.0
COMMD9	-7849.0	8429.0
COPA	7285.0	1861.0
COPB1	1831.0	-3425.0
COPB2	-2138.0	1716.0
COPE	-8076.0	8867.0
COPG1	4193.0	8829.0
COPG2	138.0	5049.0
COPS2	7220.0	7870.0
COPS3	-4803.0	5775.0
COPS4	-5225.0	7193.0
COPS5	-4890.0	5035.0
COPS6	-7632.0	686.0
COPS7A	-7427.0	7817.0
COPS7B	3212.0	95.0
COPS8	-1556.0	5747.0
COPZ1	-4766.0	-409.0
COPZ2	3788.0	-4768.0
CP	-8615.0	-7010.0
CPA3	7041.0	-5023.0
CPB1	-5530.0	-4965.0
CPB2	-6114.0	-2791.0
CPE	-6692.0	4158.0
CPM	1524.0	-861.0
CREB3	6991.0	1459.0
CREB3L1	1667.0	-3856.0
CREB3L2	-1220.0	5601.0
CREB3L3	-6990.0	4923.0
CREB3L4	-192.0	-4951.0
CREBBP	-5284.0	-2821.0
CREBRF	-6210.0	5656.0
CRHR2	-8755.0	7004.0
CSF1	-4397.0	-5310.0
CSF2RA	-6723.0	6439.0
CSF2RB	-7359.0	-2387.0
CSNK1D	-8358.0	-5733.0
CSNK2A1	1817.5	4970.5
CSNK2A2	-5978.0	-4520.0
CSNK2B	-8515.0	8824.0
CST3	-1706.0	3184.0
CTBP1	3884.0	8242.0
CTDSP2	-2819.0	1870.0
CTNNB1	1578.0	4061.0
CTR9	-84.0	-103.0
CTSA	6799.0	1871.0
CTSC	-7188.0	218.0
CTSD	2408.5	5828.5
CTSH	6338.0	-5350.0
CTSZ	1144.0	1319.0
CUL1	-2470.0	5696.0
CUL2	-3529.0	7078.0
CUL3	7639.0	562.0
CUL4A	522.0	8631.0
CUL4B	-4045.0	577.0
CUL5	-2111.0	4589.0
CUL7	-5266.0	587.0
CUL9	-3168.0	1918.0
CXXC1	6587.0	2031.0
CYLD	6950.0	-7970.0
DAD1	-3648.0	-2023.0
DAG1	-7689.0	2735.0
DAP3	7591.0	6691.0
DARS1	3713.0	-1936.0
DARS2	-4570.0	6989.0
DAXX	-8656.0	8797.0
DCAF10	4857.0	-1552.0
DCAF11	5798.5	8617.5
DCAF13	3925.0	1105.0
DCAF17	2014.0	-3650.0
DCAF4	2365.5	2139.5
DCAF5	409.0	7896.0
DCAF6	-5410.0	536.0
DCAF7	-2799.0	-1707.0
DCAF8	-8409.0	8409.0
DCP2	5710.0	3644.0
DCSTAMP	1686.0	-3462.5
DCTN1	-8106.5	8601.5
DCTN2	-1550.0	8285.0
DCTN3	-1724.0	3468.0
DCTN4	-7995.0	-778.0
DCTN5	4026.0	6171.0
DCTN6	673.0	4901.0
DCUN1D1	4491.0	-2656.0
DCUN1D2	-6110.0	7544.0
DCUN1D3	-433.0	676.0
DCUN1D4	8175.0	-7974.0
DCUN1D5	-2229.0	-55.0
DDA1	-2622.0	7646.0
DDB1	-806.0	6382.0
DDB2	4071.0	-6769.0
DDIT3	801.0	8817.0
DDOST	1892.0	4386.0
DDX11	-4722.0	-6341.0
DDX17	8189.0	-8529.0
DDX5	-2351.0	-2278.0
DDX58	-5895.0	3913.0
DERL1	-6364.0	3464.0
DERL2	5929.0	3169.0
DHDDS	-3111.0	6417.0
DHPS	34.5	6917.5
DIS3	-4712.0	-7484.0
DMP1	-1047.0	5875.0
DNAJB11	6101.5	3717.5
DNAJB9	6915.0	8651.0
DNAJC24	-6178.0	2618.0
DNAJC3	7113.0	4243.0
DNMT1	-6298.0	-7879.0
DNMT3A	-8276.0	3801.0
DNMT3B	8042.0	6488.0
DOHH	-3247.0	7435.0
DOLK	-3890.0	4468.0
DOLPP1	-6718.0	-2338.0
DPAGT1	-3179.0	5861.0
DPH1	8650.0	-8517.0
DPH2	-3608.0	4852.0
DPH3	1415.0	5837.0
DPH5	6212.0	7359.0
DPH6	5792.0	1690.0
DPH7	-3904.0	-1125.0
DPM1	-47.0	-180.0
DPM2	6085.0	-2676.0
DPM3	-2455.0	-2005.0
DPP4	8530.0	-8225.0
DTL	-1282.0	-5990.0
DYNC1H1	7671.0	6805.0
DYNC1I1	5105.0	2652.0
DYNC1I2	-5706.0	5083.0
DYNC1LI1	6461.0	7025.0
DYNC1LI2	4553.0	-2293.0
DYNLL1	1967.0	754.0
DYNLL2	-3336.0	6037.0
EARS2	6218.0	6675.0
EDEM1	7211.0	-7233.0
EDEM2	-541.0	2823.0
EDEM3	6449.0	-3295.0
EEF1A1	4479.0	-3572.0
EEF1A2	-781.0	6912.0
EEF1B2	3629.0	-1178.0
EEF1D	-2659.0	6789.0
EEF1E1	5688.5	-6156.5
EEF1G	-587.0	7364.0
EEF2	-3994.0	7672.0
EEF2KMT	5201.0	-5514.0
EIF1AX	3275.0	1762.0
EIF2AK3	5283.0	-6915.0
EIF2B1	7582.0	6111.0
EIF2B2	2453.0	5487.0
EIF2B3	2800.0	-2282.0
EIF2B4	-321.0	3331.0
EIF2B5	-5420.0	7827.0
EIF2S1	4892.0	-4087.0
EIF2S2	3572.0	4652.0
EIF2S3	134.5	2917.5
EIF3A	-4414.0	2969.0
EIF3B	1074.0	3862.0
EIF3C	1092.5	6687.5
EIF3D	-3804.0	2801.0
EIF3E	7851.0	865.0
EIF3F	-3363.0	-2887.0
EIF3G	-5106.0	5630.0
EIF3H	-5343.0	3656.0
EIF3J	1922.0	5223.0
EIF3K	-7855.0	7472.0
EIF3L	-3104.0	5482.0
EIF3M	-762.0	-4744.0
EIF4A1	1907.0	-2099.0
EIF4A2	6348.0	6429.0
EIF4E	38.0	7538.0
EIF4EBP1	-6373.0	3242.0
EIF4G1	-8382.0	8463.0
EIF4H	-2215.0	-6517.0
EIF5	3307.0	-4224.0
EIF5A	4266.5	4837.5
EIF5A2	1471.0	3100.0
EIF5B	-3547.0	6100.0
ELOB	-275.0	-4953.0
ELOC	-6650.0	5809.0
ENAM	2531.0	-6501.0
ENGASE	-5674.0	3988.0
ENPEP	6180.0	3763.0
EP300	1364.0	2866.0
EPAS1	-6815.0	3574.0
EPRS1	7534.0	7665.0
ERAL1	-5371.0	2877.0
ERCC8	7453.0	-8465.0
ERN1	-3551.0	-2628.0
ERO1A	5241.0	1249.0
ERO1B	2177.0	-1446.0
ESR1	8600.0	6696.0
ETF1	-32.0	4014.0
ETFB	-2415.0	6029.0
ETFBKMT	6463.0	-3235.0
EVA1A	6087.0	-2210.0
EXOC1	-8093.0	508.0
EXOC2	-7541.0	-7471.0
EXOC3	-2139.0	8555.0
EXOC4	-8192.0	4531.0
EXOC5	3879.0	300.0
EXOC6	6523.0	-1953.0
EXOC7	-5774.0	4583.0
EXOC8	6610.0	-1045.0
EXOSC1	-8171.0	-7995.0
EXOSC2	8133.0	-8130.0
EXOSC3	4998.0	-6763.0
EXOSC4	2630.0	-2137.0
EXOSC5	-5309.0	3404.0
EXOSC6	5945.0	4802.0
EXOSC7	6112.0	-4064.0
EXOSC8	5872.0	-5758.0
EXOSC9	5899.0	-2650.0
EXTL1	-1742.0	7967.0
EXTL2	4792.0	7149.0
EXTL3	-2872.0	5514.0
F10	-8303.0	-5486.0
F2	-3364.0	634.0
F5	-8081.0	-6347.0
F7	-5042.0	-2478.0
F8	-1145.0	-4955.0
F9	-5523.0	534.0
FAM20A	5484.0	-738.0
FAM20C	706.0	-3219.0
FARS2	814.0	8586.0
FARSA	1666.0	3030.0
FARSB	-1329.0	1464.0
FAU	-8349.0	-6727.0
FBN1	5549.0	-5406.0
FBXL12	-325.0	1584.0
FBXL13	-4520.0	-6099.0
FBXL15	-2822.0	5287.0
FBXL16	-7485.0	-7345.0
FBXL18	-1763.0	-1324.0
FBXL19	7441.0	8682.0
FBXL20	-3216.0	3165.0
FBXL22	-6079.0	6282.0
FBXL3	7325.0	-8281.0
FBXL4	1339.0	-8147.0
FBXL5	6906.0	-2474.0
FBXL7	1971.0	-3306.0
FBXL8	2994.5	-4989.5
FBXO10	-248.0	-7973.0
FBXO11	-1590.0	5802.0
FBXO15	-2158.0	-4065.0
FBXO17	-6757.0	5736.0
FBXO2	5515.0	-2334.0
FBXO21	596.0	5085.0
FBXO22	-1248.0	649.0
FBXO27	-2190.0	3345.0
FBXO30	-153.0	5895.0
FBXO31	-2548.0	8762.0
FBXO32	-5253.0	2015.0
FBXO4	6331.0	794.0
FBXO40	-3095.0	6634.0
FBXO41	-4578.0	-4826.0
FBXO6	6793.0	2788.0
FBXO7	-7288.0	-4113.0
FBXO9	5911.0	4793.0
FBXW10	-5852.5	8189.5
FBXW11	-7722.0	-1164.0
FBXW12	764.0	3057.0
FBXW2	517.0	257.0
FBXW4	869.0	-3401.0
FBXW5	-2230.0	7454.0
FBXW7	-3943.0	-3560.0
FBXW8	-86.0	7578.0
FBXW9	-904.0	-8072.0
FCGR3B	-6425.5	4742.5
FCSK	-5403.0	-1047.0
FEM1A	433.0	7752.0
FEM1B	6956.0	-2640.0
FEM1C	-1346.0	-571.0
FFAR4	1003.0	-1075.0
FGA	-8420.0	-6269.0
FGF23	2936.0	-4966.0
FGG	-7760.0	-6173.0
FKBP14	4960.0	431.0
FKBP8	-1695.0	7701.0
FKBP9	7342.0	-6069.0
FN1	6620.0	-6064.0
FN3K	6107.0	8070.0
FN3KRP	2436.0	-2978.0
FOLR2	1001.0	3958.0
FOXK1	-1698.0	2345.0
FOXK2	4330.0	-4119.0
FOXL2	-867.5	83.0
FOXO4	-8609.0	8547.0
FPGT	7966.0	6799.0
FSTL1	7312.0	-6427.0
FSTL3	5540.0	702.0
FUCA1	5529.0	6547.0
FUCA2	-5945.0	-5617.0
FUOM	5883.0	6307.0
FURIN	-6129.0	-521.0
FUT8	-2766.0	-1993.0
GADD45GIP1	3684.0	5202.0
GALNT1	-1493.0	-2241.0
GALNT10	5071.0	-4940.0
GALNT11	6234.0	76.0
GALNT12	7773.0	-3701.0
GALNT13	964.0	-5680.0
GALNT14	3775.0	1025.0
GALNT15	78.0	3998.0
GALNT16	-1598.0	-3067.0
GALNT17	1266.0	-8274.0
GALNT18	5414.0	4760.0
GALNT2	-2208.0	8699.0
GALNT3	494.0	2458.0
GALNT5	1434.0	-3743.0
GALNT6	-2323.0	-1966.0
GALNT7	-1148.0	-7717.0
GALNT9	8219.0	1994.0
GALNTL5	-137.0	4685.0
GALNTL6	4335.0	-5216.0
GAN	5733.0	3328.0
GANAB	1196.0	3629.0
GAPDHS	-4469.0	6757.0
GARS1	7347.0	4390.0
GAS6	2959.0	8889.0
GATA3	-1419.0	4322.0
GATA4	-3182.0	6474.0
GATA6	-6688.0	4426.0
GBA	-3563.0	2605.0
GBF1	-5647.0	8230.0
GCNT1	3968.0	1410.0
GCNT3	-3667.0	-6404.0
GCNT4	5189.0	-1084.0
GCNT7	1080.0	6356.0
GFM1	-5362.0	8253.0
GFM2	685.0	8246.0
GFPT1	6009.0	3683.0
GFPT2	7543.0	-2033.0
GGA1	1098.0	-4458.0
GGA2	6299.0	3368.0
GGA3	-2185.0	6838.0
GGCX	7570.0	-8290.0
GHRL	4173.0	3325.0
GLB1	-4568.0	5019.0
GMDS	6421.0	-532.0
GMPPA	5092.0	1250.0
GMPPB	-72.0	3539.0
GNAI1	-7376.0	5037.0
GNAI2	-4164.0	-1806.0
GNAI3	3460.0	-7071.0
GNAO1	-4885.0	3280.0
GNAT1	3151.0	-1339.0
GNAT2	-5007.0	-6197.0
GNAT3	1097.0	7559.0
GNAZ	5963.0	-1529.0
GNB1	-3640.0	-6683.0
GNB2	5974.0	-7330.0
GNB3	7638.0	7679.0
GNB4	-4332.0	-7844.0
GNB5	-107.0	-6520.0
GNE	7778.0	-8183.0
GNG10	6819.0	-2589.0
GNG11	3479.0	-2086.0
GNG12	-5616.0	-1630.0
GNG13	-1861.0	-5806.0
GNG2	6500.0	-4950.0
GNG3	3036.0	-91.0
GNG4	-7043.0	-588.0
GNG5	826.0	6410.0
GNG7	-2816.0	-6814.0
GNG8	6323.0	6548.0
GNGT2	4096.0	4482.0
GNPNAT1	8122.0	-7892.0
GOLGB1	-741.0	-1361.0
GOLM1	-6926.0	5536.0
GORASP1	-4724.0	8498.0
GOSR1	2779.0	-5663.0
GOSR2	1218.5	1679.5
GPAA1	-3371.0	6653.0
GPC3	-1882.0	-3616.0
GPIHBP1	-3154.0	-5543.0
GPLD1	-4879.0	-3214.0
GPR119	-4110.0	-4917.0
GPS1	-7074.0	8502.0
GRIA1	3344.0	-8115.0
GSK3A	-3011.0	3103.0
GSN	7744.0	309.0
GSPT1	4620.0	8403.0
GSPT2	2429.0	-6613.0
GZMH	-658.5	838.5
H2AC1	-3686.0	4495.0
H2AC21	-2669.0	4180.0
H2AZ1	-701.0	5186.0
H2BC1	-7751.0	2405.0
H2BC11	6509.0	1218.0
H2BC12	-3358.0	-6907.0
H2BC3	-3382.0	-5819.0
H2BU1	5369.0	-6065.0
H3-3A	-1709.0	-7777.0
H4C1	6630.5	-8331.5
HARS1	6567.0	3942.0
HARS2	7265.0	7381.0
HCFC1	-6300.0	-3186.0
HDAC1	6882.0	-4705.0
HDAC2	3280.0	3352.0
HDAC3	5261.0	761.0
HDAC4	-4552.0	-1592.0
HDAC7	-1599.0	394.0
HDGF	-8058.0	8185.0
HERC2	6474.0	7956.0
HERPUD1	4836.0	8040.0
HGS	-5517.0	7748.0
HIC1	6810.0	7961.0
HIF1A	-6242.0	-6737.0
HIF3A	-5525.0	3693.0
HIPK2	-1941.0	4168.0
HLA-A	-7843.5	-5402.5
HLA-B	-7843.5	-5402.5
HLTF	-5652.0	-7051.0
HNRNPK	-8476.0	-6074.0
HRC	-5542.0	3729.0
HSP90B1	1485.0	5927.0
HSPA5	5831.0	7159.0
HSPA8	382.0	7793.0
HSPG2	-3510.0	-2622.0
HYOU1	6010.0	7062.0
IAPP	181.5	838.5
IARS1	6979.0	8593.0
IARS2	-2969.0	8731.0
ICMT	-6431.0	-5019.0
IDE	-7664.0	-264.0
IFIH1	-1718.0	-2808.0
IGF1	7818.0	-8448.0
IGF2	-8687.0	7871.0
IGFALS	-1278.0	642.0
IGFBP1	-6772.0	-6628.0
IGFBP2	-7440.0	1408.0
IGFBP3	514.0	-6146.0
IGFBP4	-3746.0	-4166.0
IGFBP5	-5058.0	401.0
IGFBP6	7962.0	3898.0
IGFBP7	1973.0	-1154.0
IKBKE	3431.0	3418.0
IKBKG	2865.0	5671.0
IL33	5523.0	3011.0
IL6	-3355.0	-3824.0
INCENP	7865.0	-2966.0
ING2	-4078.0	1518.0
INHA	-767.0	-4278.0
INHBA	7014.0	-555.0
INHBB	1884.0	-911.0
INHBC	-2935.0	1424.0
INHBE	-4906.0	3380.0
INO80	-1033.0	-7154.0
INO80B	-3376.5	6608.5
INO80C	-5856.0	6018.0
INO80D	962.0	-2760.0
INO80E	-5894.0	7220.0
INS	721.5	-2721.0
ISL1	5756.0	4607.0
ITIH2	-8185.0	1362.0
ITM2B	-5408.0	950.0
IZUMO1R	2672.0	3596.0
JOSD1	5816.0	3858.0
JOSD2	4439.0	3396.0
KARS1	521.0	6337.0
KAT2A	-5831.0	5172.0
KAT2B	2695.0	5911.0
KBTBD6	5280.5	-7816.5
KBTBD7	5280.5	-7816.5
KBTBD8	5954.0	3681.0
KCTD6	2950.0	-4104.0
KCTD7	3928.0	-864.0
KDELR1	-3700.0	-2780.0
KDELR2	1312.0	-6808.0
KDELR3	8569.0	-7580.0
KDM1B	-2871.0	-6194.0
KEAP1	297.0	6401.0
KHSRP	-1028.0	-7170.0
KIF13A	-5228.0	548.0
KIF5A	-6250.0	7971.0
KIF5B	6203.0	-2941.0
KIF5C	7923.0	-2919.0
KIFC3	-747.0	7626.0
KIN	-3313.0	4379.0
KLF4	5263.0	-1401.0
KLHDC3	-3431.0	7071.0
KLHL11	3597.0	-4926.0
KLHL13	-5035.0	-6378.0
KLHL2	-547.0	-6141.0
KLHL20	-455.0	-4764.0
KLHL21	2993.0	5348.0
KLHL22	-6895.5	8302.5
KLHL25	2578.0	3871.0
KLHL3	2173.0	3901.0
KLHL41	-4848.0	2520.0
KLHL42	-1321.0	1473.0
KLHL5	6932.0	-1742.0
KLHL9	2410.0	-511.0
KLK13	-275.0	810.5
KLK2	1233.5	335.5
KLK3	1233.5	335.5
KNG1	-8772.0	-8546.0
KTN1	1879.0	4821.0
L3MBTL2	6253.0	-4493.0
LAMB1	136.0	-5392.0
LAMB2	-7435.0	7273.0
LAMC1	-3226.0	-7305.0
LARGE1	-2716.0	7690.0
LARGE2	-6479.0	-3065.0
LARS1	664.0	542.0
LARS2	2455.0	8388.0
LEO1	-7120.0	1124.0
LEP	-3875.0	-2047.0
LGALS1	-305.0	2308.0
LMAN1	6017.0	6864.0
LMAN1L	-2744.0	-844.0
LMAN2	7531.0	5511.0
LMAN2L	4161.0	5688.0
LMCD1	-3710.0	6933.0
LMNA	8469.0	8154.0
LMO7	-5271.0	-2110.0
LONP2	-8225.0	8600.0
LRR1	-7165.0	-5464.0
LRRC41	-3926.0	2688.0
LRRC49	4223.0	3661.0
LSAMP	2098.0	-7444.0
LTBP1	6223.0	-1278.0
LTF	1475.0	-6546.0
LY6G6C	-1892.0	-7506.0
LY6G6D	6715.0	-4213.0
LY6H	-8586.0	165.0
LYPD1	-5629.0	-5910.0
LYPD2	-4755.0	-5540.0
LYPD3	5871.0	2691.0
LYPD5	3669.0	810.5
LYPD6B	-6200.0	52.0
LYPD8	-3243.5	-2719.5
LYZ	-135.0	-4055.0
MAGT1	1861.0	-7538.0
MAN1A1	-8046.0	-8294.0
MAN1A2	5119.0	1705.0
MAN1B1	4142.0	-3939.0
MAN1C1	5643.0	745.0
MAN2A1	8475.0	-6852.0
MAN2A2	-4380.0	8055.0
MANEA	112.0	-7158.0
MAP3K7	2561.0	-3604.0
MARCHF6	2789.0	3680.0
MARS1	3978.0	5741.0
MARS2	7803.0	7855.0
MAT2B	7935.0	7964.0
MATN3	4048.0	1207.0
MAVS	-3868.0	8125.0
MBD1	-5768.0	2902.0
MBD5	-2073.0	5995.0
MBD6	-1151.0	-1400.0
MBOAT4	1654.0	5881.0
MBTPS1	-7530.0	-7884.0
MBTPS2	-8485.0	-7477.0
MCFD2	-8595.0	7190.0
MCRS1	-1661.0	1040.0
MDC1	-8359.0	-8180.0
MDGA1	1926.0	5590.0
MDGA2	-453.0	4918.0
MDM2	-7130.0	6576.0
MDM4	5289.0	-2384.0
MELTF	4546.0	1925.0
MEN1	-497.0	6590.0
MEPE	-7529.0	7698.0
METTL21A	-1267.0	6552.0
METTL22	-6046.0	5810.0
MFGE8	-6514.0	8782.0
MGAT1	-5478.0	2274.0
MGAT2	2375.0	2958.0
MGAT3	-5328.0	-4127.0
MGAT4A	-213.0	-6745.0
MGAT4B	1985.0	-5504.0
MGAT4C	2243.0	-6302.0
MGAT5	990.0	-6012.0
MIA2	8537.0	8875.0
MIA3	-6283.0	7631.0
MITF	5056.0	5156.0
MLEC	7616.0	7732.0
MME	8144.0	-7498.0
MMP2	7246.0	-1051.0
MOGS	-994.0	-2101.0
MPDU1	-3922.0	3371.0
MPI	889.0	6101.0
MRPL1	8264.0	7549.0
MRPL10	2998.0	8086.0
MRPL11	3525.0	6331.0
MRPL12	3990.0	7781.0
MRPL13	3516.0	5678.0
MRPL14	6574.0	7116.0
MRPL15	997.0	6964.0
MRPL16	-2084.0	1260.0
MRPL17	6725.0	6453.0
MRPL18	3086.0	2055.0
MRPL19	2255.0	7329.0
MRPL2	6957.0	4885.0
MRPL20	4321.0	4290.0
MRPL21	1036.0	1621.0
MRPL22	4861.0	5203.0
MRPL24	5886.0	5906.0
MRPL27	1882.0	-1669.0
MRPL28	-3666.0	7741.0
MRPL3	3631.0	5677.0
MRPL30	-4228.5	8621.5
MRPL32	3203.0	3553.0
MRPL33	2952.0	6991.0
MRPL34	-4124.0	6893.0
MRPL35	3331.0	4469.0
MRPL36	8170.0	8030.0
MRPL37	-7011.0	8256.0
MRPL38	-3883.0	8264.0
MRPL39	287.0	6476.0
MRPL4	-4539.0	7792.0
MRPL40	5081.0	3168.0
MRPL41	-4190.0	1609.0
MRPL42	5782.0	7034.0
MRPL43	2921.0	-1127.0
MRPL44	3657.0	7306.0
MRPL45	5550.0	7688.0
MRPL46	4658.0	6980.0
MRPL47	4297.0	6174.0
MRPL48	-1052.0	994.0
MRPL49	455.0	5109.0
MRPL50	5332.0	5947.0
MRPL51	-6613.0	1221.0
MRPL52	2389.0	3907.0
MRPL53	459.0	6650.0
MRPL54	338.0	6267.0
MRPL55	611.0	5042.0
MRPL58	-2779.0	7028.0
MRPL9	-1324.0	7335.0
MRPS10	-2447.0	2655.0
MRPS11	-727.0	4948.0
MRPS12	-374.0	4749.0
MRPS14	8631.0	6963.0
MRPS15	-320.0	7601.0
MRPS16	2291.0	-1381.0
MRPS17	-7600.5	7822.5
MRPS18A	-1632.0	6064.0
MRPS18B	8262.0	8890.0
MRPS18C	2306.0	2956.0
MRPS2	5511.0	6971.0
MRPS21	-5796.0	7006.0
MRPS22	-1284.0	2647.0
MRPS23	1447.0	6906.0
MRPS24	8268.0	5944.0
MRPS25	-3030.0	1709.0
MRPS26	-812.0	4995.0
MRPS27	-2570.0	3542.0
MRPS28	8263.0	-1755.0
MRPS30	42.0	7396.0
MRPS31	256.0	3382.0
MRPS33	4225.0	2565.0
MRPS34	-43.0	8171.0
MRPS35	7323.0	-2492.0
MRPS36	-6157.0	-2809.0
MRPS5	-52.0	7980.0
MRPS6	3681.0	6183.0
MRPS7	-140.0	5327.0
MRPS9	3979.0	7008.0
MRRF	-4728.0	3344.0
MRTFA	-8070.0	-7272.0
MSLN	-1833.0	-2550.0
MSRA	-8251.0	-7177.0
MSRB1	3338.0	5572.0
MSRB2	6111.0	6490.0
MSRB3	-4907.0	-1768.0
MTFMT	-3519.0	-5633.0
MTIF2	1057.0	2775.0
MTIF3	4789.0	2023.0
MTRF1L	-6036.0	2943.0
MUC1	7081.0	1215.0
MUC13	2897.0	-7593.0
MUC15	1040.0	-8018.0
MUC16	360.0	-2959.0
MUC19	-807.0	-5252.0
MUC20	-2796.0	-3102.0
MUC4	-5294.0	3509.0
MUC5B	-4108.0	192.0
MUC6	7090.0	-592.0
MUL1	-6342.0	5748.0
MVD	-800.0	6215.0
MXRA8	8446.0	-6389.0
MYC	-7858.0	5713.0
MYDGF	-79.0	4449.0
MYO5A	8470.0	-8364.0
MYRIP	-5716.0	5451.0
MYSM1	8058.0	-3729.0
N6AMT1	-4603.0	6206.0
NAE1	634.0	-3520.0
NAGK	2971.0	-4069.0
NANP	1510.0	-4327.0
NANS	-1129.0	5238.0
NAPA	-7401.0	7713.0
NAPB	-4370.0	6622.0
NAPG	1499.0	1039.0
NAPSA	2956.0	4890.0
NARS1	7904.0	8630.0
NARS2	7594.0	8507.0
NAT8	7131.5	-1306.5
NAT8B	7131.5	-1306.5
NCOA1	-6462.0	-3286.0
NCOA2	-4921.0	152.0
NCOR2	-8231.0	-238.0
NCSTN	-7938.0	6961.0
NDC1	5943.0	-442.0
NEDD8	4019.0	7619.0
NEGR1	5757.0	-7004.0
NEU1	8466.0	8608.0
NEU2	-4961.0	4818.0
NEU3	2720.0	-289.0
NEU4	3345.0	4113.0
NEURL2	3366.0	6712.0
NFKB2	-1871.0	5814.0
NFRKB	-8253.0	8027.0
NFYA	1966.0	7015.0
NFYB	-8007.0	1927.0
NFYC	-4084.0	7696.0
NGLY1	1678.0	-3877.0
NICN1	-6838.0	8538.0
NLRP3	3861.0	-7951.0
NOD1	-182.0	7988.0
NOD2	-8346.0	-3204.0
NOP56	4633.0	-1632.0
NOP58	5486.0	-7179.0
NOTUM	-2026.0	-5225.0
NPL	2273.0	3772.0
NPM1	3936.0	-6434.0
NPPA	3606.0	7183.0
NR1H2	-4706.0	-1579.0
NR1H3	-7111.0	5311.0
NR1H4	4318.0	-7115.0
NR1I2	-7893.0	-6453.0
NR2C1	6943.0	-4836.0
NR3C1	-7729.0	5212.0
NR3C2	-3702.0	-964.0
NR4A2	-8243.0	4720.0
NR5A1	-3276.0	-2835.0
NR5A2	5374.0	-8134.0
NRIP1	8107.0	-3150.0
NRN1	2500.0	103.0
NSF	-7496.0	-4376.0
NSMCE1	4279.0	8610.0
NSMCE2	-5896.0	-8140.0
NSMCE3	3916.0	2994.0
NSMCE4A	-615.0	-4331.0
NTM	2937.0	-2473.0
NTNG1	-7446.0	-7888.0
NTNG2	5931.0	-6372.0
NUB1	-7122.0	5454.0
NUCB1	-6537.0	2126.0
NUDT14	1270.0	2907.0
NUP107	770.0	-4987.0
NUP133	-3867.0	-5218.0
NUP153	6561.0	3197.0
NUP155	4390.0	-5945.0
NUP160	5614.0	-1355.0
NUP188	2881.0	-1808.0
NUP205	-2971.0	-126.0
NUP210	-4075.0	-1647.0
NUP214	-8456.0	-8322.0
NUP35	2300.0	3137.0
NUP37	8306.0	-8104.0
NUP42	-38.0	3012.0
NUP43	-7853.0	-3161.0
NUP50	3023.0	7983.0
NUP54	2383.0	-72.0
NUP58	8481.0	7137.0
NUP62	-2850.0	4347.0
NUP85	-7742.0	-3075.0
NUP88	2082.0	-764.0
NUP93	5076.0	-4859.0
NUP98	6285.0	-4382.0
NUS1	7322.0	5980.0
OBSL1	940.0	1960.0
ODAM	742.0	48.0
OGT	8384.0	-7828.0
OPCML	-1326.0	-7899.0
OS9	-5143.0	4690.0
OTOA	4989.0	-1556.0
OTUB1	-2328.0	5854.0
OTUB2	-1884.0	3640.0
OTUD3	8270.0	6551.0
OTUD5	-65.0	4535.0
OTUD7A	-2806.0	-3460.0
OTUD7B	-6269.0	3273.0
OTULIN	-1651.0	7966.0
OXA1L	-3990.0	7178.0
P2RY2	-2186.0	-5109.0
P4HB	-2194.0	6155.0
PAF1	-4713.0	-8137.0
PAPPA	-8207.0	-8430.0
PAPPA2	774.0	-291.0
PARK7	-8340.0	8811.0
PARN	-8136.0	-8549.0
PARP1	-6888.0	6203.0
PARS2	7234.0	2108.0
PAX6	-4939.0	7357.0
PCGF2	-6347.0	-2070.0
PCMT1	4105.0	5373.0
PCNA	2802.0	-3083.0
PCSK1	-2261.0	1219.0
PCSK2	6409.0	-3386.0
PCSK9	-5901.0	7270.0
PDCL	-1298.0	-4045.0
PDIA3	-1482.0	-1751.0
PDIA5	72.0	-7576.0
PDIA6	5501.0	16.0
PENK	-2046.0	6173.0
PEX10	-5618.0	8104.0
PEX12	-7360.0	-237.0
PEX13	-6359.0	-2647.0
PEX14	2806.0	6149.0
PEX2	5254.0	3552.0
PEX5	4433.0	-256.0
PFDN1	1726.0	4904.0
PFDN2	-209.0	1378.0
PFDN4	7410.0	-5979.0
PFDN5	5850.0	4157.0
PFDN6	682.0	8433.0
PGAP1	3505.0	3940.0
PGM3	5778.0	-2541.0
PGR	4275.0	3624.0
PHC1	-6716.0	2341.0
PHC2	-3513.0	4405.0
PHC3	-3683.0	-4968.0
PIAS1	7240.0	-7849.0
PIAS2	-2374.0	-4626.0
PIAS3	-103.0	-2329.0
PIAS4	1961.0	7802.0
PIGA	-3597.0	-163.0
PIGB	5884.0	6448.0
PIGC	2013.0	6413.0
PIGF	-7374.0	-1181.0
PIGG	-6101.0	-601.0
PIGH	-422.0	426.0
PIGK	8165.0	4819.0
PIGL	620.0	-4419.0
PIGM	-7318.0	-430.0
PIGN	1404.0	-7257.0
PIGO	1939.0	-2103.0
PIGP	5765.0	-4631.0
PIGQ	-4994.0	-282.0
PIGS	-6214.0	3561.0
PIGT	-3460.0	2231.0
PIGU	7324.0	-1462.0
PIGV	392.0	-3944.0
PIGW	-2639.0	-2639.0
PIGX	6877.0	1138.0
PIGY	3.0	-1372.0
PLA2G4B	4501.5	-3527.5
PLA2G7	3741.0	5602.0
PLAUR	3593.0	4854.0
PLET1	7788.0	-1983.0
PLG	-8727.0	-6409.0
PML	-4509.0	-218.0
PMM1	6031.0	4756.0
PMM2	-2921.0	7485.0
PNPLA2	-3928.0	3795.0
POFUT2	5612.0	6751.0
POLB	1927.0	2472.0
POM121	-3479.5	-928.5
POM121C	-3479.5	-928.5
POMC	2992.0	4075.0
POMGNT1	-4511.0	-5044.0
POMGNT2	4520.0	3794.0
POMK	4726.0	-3444.0
POMT1	-7672.0	6226.0
POMT2	1190.0	-1610.0
PPA1	6963.0	5621.0
PPA2	7765.0	-5688.0
PPARA	-226.0	6604.0
PPARG	-8223.0	-3183.0
PPARGC1A	2820.0	1081.0
PPP2R5B	6483.0	4675.0
PPP6C	841.0	-3047.0
PPP6R1	-6569.0	8453.0
PPP6R3	-1616.0	1481.0
PREB	-5464.0	4170.0
PRKCSH	-5004.0	3941.0
PRKDC	-3410.0	-2306.0
PRL	-8787.0	-8320.0
PRMT3	7810.0	8415.0
PRND	-3915.0	-6261.0
PROC	-3705.0	-1136.0
PROS1	4415.0	-5354.0
PROZ	4590.0	7066.0
PRSS21	2766.0	1579.0
PRSS23	6954.0	-7295.0
PSCA	4227.0	-3203.0
PSENEN	-1700.0	-2602.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
PTCD3	7969.0	8800.0
PTEN	-2571.0	6959.0
PTP4A2	4972.0	1257.0
PTRH2	1449.0	-4963.0
PUM2	2105.0	-6794.0
QSOX1	-692.0	8085.0
RAB10	-3152.0	1981.0
RAB11A	-5703.0	4222.0
RAB11B	-7787.0	5154.0
RAB12	5890.0	1471.0
RAB13	8297.5	2070.5
RAB14	-1225.0	1120.0
RAB15	5594.0	-5428.0
RAB17	-4527.0	-5559.0
RAB18	-2053.0	648.0
RAB19	-4321.0	-3774.0
RAB1A	7478.0	-5059.0
RAB1B	-2273.0	7299.0
RAB20	-2034.0	2156.0
RAB21	1712.0	5752.0
RAB22A	-1843.0	7039.0
RAB23	7550.0	-2261.0
RAB24	4794.0	-1232.0
RAB25	864.0	5871.0
RAB26	-3831.0	-5316.0
RAB27A	-318.0	-5492.0
RAB27B	4268.0	-3045.0
RAB29	-1876.0	-2220.0
RAB2A	-1551.0	1227.0
RAB2B	-1352.0	-3500.0
RAB30	7022.0	8113.0
RAB31	-1492.0	-2714.0
RAB33A	7566.0	2459.0
RAB33B	2899.0	-4442.0
RAB34	7074.0	-6104.0
RAB35	-233.0	4979.0
RAB36	4934.0	6952.0
RAB37	-7252.0	-5196.0
RAB38	-1183.0	-2828.0
RAB39A	4229.0	-4995.0
RAB3A	987.0	6066.0
RAB3B	4453.0	-2004.0
RAB3C	-7512.0	-6506.0
RAB3D	1860.0	-1583.0
RAB40B	-126.0	2684.0
RAB40C	1246.0	3753.0
RAB42	3760.0	-6830.0
RAB43	-3664.0	-5567.0
RAB44	-4770.0	-323.0
RAB4A	4583.0	7363.0
RAB4B	1731.5	6098.5
RAB5A	-1080.0	2003.0
RAB5B	-5518.0	7045.0
RAB5C	-8111.0	4674.0
RAB6A	6472.0	4942.0
RAB6B	-5431.0	-6246.0
RAB7A	5264.0	-1721.0
RAB7B	4580.0	-5245.0
RAB8A	5009.0	-4448.0
RAB8B	-136.0	-6508.0
RAB9A	3903.0	-5922.0
RAB9B	2403.0	2397.0
RABGGTA	1812.0	3432.0
RABGGTB	3784.0	1928.0
RAD18	-2113.0	-1625.0
RAD21	327.0	-6348.0
RAD23A	-8502.0	8501.0
RAD23B	4713.0	5544.0
RAD52	-1547.0	8706.0
RAE1	-4200.0	-5786.0
RANBP2	6652.0	1313.0
RANGAP1	-5209.0	8599.0
RARA	-8256.0	-6828.0
RARS1	-367.0	1437.0
RARS2	2776.0	4302.0
RBBP5	4921.0	5717.0
RBBP7	-6158.0	5391.0
RBX1	92.0	4055.0
RCE1	5958.0	2666.0
RCN1	6043.5	-1440.5
RECK	7979.0	-6011.0
RELA	-1883.0	-6107.0
REN	-7121.0	7088.0
RENBP	6205.0	3045.0
RFT1	4012.5	-2822.5
RGS6	-8182.0	3016.0
RGS7	3146.0	-3095.0
RGS9	4793.0	-2317.0
RHOA	-580.0	1949.0
RHOT1	8437.0	8316.0
RING1	-7177.0	8366.0
RIPK1	-1513.0	-5850.0
RIPK2	-3840.0	-1651.0
RNF103	6982.0	-423.0
RNF123	-4505.0	5026.0
RNF128	8158.0	-3832.0
RNF139	-482.0	-609.0
RNF144A	5547.0	-4191.0
RNF146	-4369.0	2991.0
RNF152	4800.0	-1831.0
RNF168	-1675.0	-4132.0
RNF185	-6526.0	6567.0
RNF2	7873.0	-7769.0
RNF20	-3946.0	-4971.0
RNF40	-5361.0	7770.0
RNF5	6460.0	8372.0
RNF7	6638.0	1030.0
RORA	981.0	-3060.0
RPA1	-8218.0	8736.0
RPL10A	540.0	4827.0
RPL10L	6226.0	-4646.0
RPL13	-6936.0	5766.0
RPL13A	8662.0	8769.0
RPL15	-5860.0	4087.0
RPL18	2526.0	4846.0
RPL18A	-1925.0	4548.0
RPL19	4213.0	6491.0
RPL21	181.5	45.0
RPL22	5649.0	1761.0
RPL23	-1809.0	3014.0
RPL23A	-6572.0	-7943.0
RPL24	-3019.0	1992.0
RPL27	2645.0	-5667.0
RPL28	-3044.0	6689.0
RPL29	8624.0	6370.0
RPL3	8648.0	-7240.0
RPL30	7077.0	-6538.0
RPL31	5384.0	-1644.0
RPL35	-2959.0	5845.0
RPL35A	-8622.0	-4858.0
RPL36	1102.0	-1619.0
RPL37	7745.0	359.0
RPL37A	1829.0	295.0
RPL38	-5365.0	-4825.0
RPL3L	-6787.0	5079.0
RPL5	3976.0	-4117.0
RPL6	8594.0	-7663.0
RPL7	2882.0	-3180.0
RPL7A	6807.0	-2288.0
RPL8	-3908.0	2263.0
RPL9	4597.0	4414.0
RPLP1	-600.0	-6598.0
RPLP2	6247.0	8473.0
RPN1	-2116.0	1586.0
RPN2	5012.0	6231.0
RPS10	-1770.5	6339.5
RPS11	2070.0	6190.0
RPS13	3415.0	-8357.0
RPS14	5495.0	5365.0
RPS15	5952.0	535.0
RPS15A	8625.0	-4215.0
RPS16	8612.0	-7367.0
RPS17	-1744.0	-7106.0
RPS18	6266.0	-6297.0
RPS19	1867.0	-6360.0
RPS2	-1499.0	-3494.0
RPS21	3740.0	-6563.0
RPS23	6740.0	-2710.0
RPS25	-221.0	-4349.0
RPS26	4910.0	3317.0
RPS27A	7076.0	2193.0
RPS27L	-2849.0	1056.0
RPS28	2906.0	-86.0
RPS3	2452.0	-3227.0
RPS3A	4511.0	126.0
RPS4X	2298.0	4334.0
RPS5	5938.0	1963.0
RPS6	-5452.0	3079.0
RPS7	-1931.0	5162.0
RPS8	3111.0	1095.0
RPS9	-7262.0	7861.0
RPSA	-1325.0	5495.0
RRAGA	1911.0	1066.0
RTF1	-3982.0	5700.0
RTN4RL1	5578.0	6006.0
RTN4RL2	341.0	-4265.0
RUVBL1	-7628.0	8138.0
RWDD3	-3545.0	-6577.0
RXRA	-4958.0	387.0
SAE1	6318.0	1849.0
SAFB	-696.0	5160.0
SAR1B	871.0	6219.0
SARS1	-5348.0	1659.0
SARS2	-5658.5	3876.5
SATB1	-3695.0	4937.0
SATB2	8045.0	1244.0
SBSPON	-1507.0	-481.0
SCFD1	1988.0	-1683.0
SCG2	-5952.0	-1336.0
SCG3	-2191.0	-6979.0
SCMH1	7287.0	4998.0
SDC2	6159.0	-6681.0
SEC11A	1644.0	-2938.0
SEC11C	-200.0	5402.0
SEC13	880.0	-1374.0
SEC16A	-3945.0	-286.0
SEC16B	-1158.0	6091.0
SEC22A	2845.0	-2395.0
SEC22B	8525.0	-7613.0
SEC22C	3309.0	-6975.0
SEC23A	-1026.0	-37.0
SEC23IP	-1293.0	-5975.0
SEC24A	-6042.0	-8065.0
SEC24B	-4899.0	-3709.0
SEC24D	5545.0	6983.0
SEC31A	-4106.0	-4555.0
SEC61A1	6679.0	-2336.0
SEC61A2	-5123.0	-5600.0
SEC61B	2781.0	-5229.0
SEC61G	-2606.0	8052.0
SEL1L	6297.0	4440.0
SELENOS	8432.0	8426.0
SEMA5A	-8274.0	1379.0
SEMA5B	-4215.0	-4148.0
SEMG1	-120.0	1741.5
SENP1	-3372.0	-7836.0
SENP2	2331.0	5318.0
SENP5	8171.0	4331.0
SENP8	-1405.0	462.0
SERP1	5857.0	-3039.0
SERPINA10	-1121.0	-5666.0
SERPINC1	2027.0	-8490.0
SERPIND1	-5483.0	-8087.0
SFTPA1	1207.5	-2450.5
SFTPA2	1207.5	-2450.5
SFTPB	2777.0	6371.0
SFTPC	2982.0	4895.0
SFTPD	-3220.0	6106.0
SHC1	7350.0	-969.0
SHISA5	5471.0	4367.0
SHPRH	-8024.0	-6170.0
SIAH1	6130.0	-7319.0
SIAH2	-1051.0	-3718.0
SIN3A	-8282.0	-5944.0
SKIV2L	-7965.0	6934.0
SKP1	944.0	7264.0
SKP2	-5129.0	-4161.0
SLC17A5	4947.0	1430.0
SLC30A5	5704.0	6438.0
SLC30A6	-4893.0	3708.0
SLC30A7	-674.0	-7110.0
SLC30A8	-8418.0	2982.0
SLC34A1	-827.0	-2180.0
SLC34A2	-7521.0	5640.0
SLC35A1	4594.0	-8220.0
SLC35C1	7066.0	4298.0
SMAD1	-608.0	-4245.0
SMAD2	7209.0	-8313.0
SMAD3	-28.0	-3448.0
SMAD4	-6666.0	-5029.0
SMAD7	8028.0	5135.0
SMC1A	-2345.0	1827.0
SMC3	-2220.0	6005.0
SMC6	-508.0	590.0
SMURF2	14.0	2516.0
SNCA	868.0	5774.0
SNCAIP	-1323.0	-6544.0
SOCS2	8118.0	6725.0
SOCS3	3723.0	5509.0
SOCS5	6902.0	1731.0
SOCS6	-1498.0	1142.0
SP100	4675.0	-3477.0
SP3	-5003.0	1540.0
SPACA4	-3852.0	-6335.0
SPARCL1	289.0	-4741.0
SPCS1	-3681.0	2689.0
SPCS2	1161.0	1192.0
SPCS3	703.0	-3225.0
SPHK1	5895.0	-8231.0
SPON1	7917.0	3199.0
SPON2	7536.0	-7895.0
SPP1	-7378.0	6546.0
SPP2	-2109.0	-343.0
SPRN	4931.0	-5037.0
SPSB1	4765.0	-7026.0
SPSB2	-6604.0	-102.0
SPSB3	6960.0	8020.0
SPSB4	5969.0	7712.0
SPTA1	-757.0	7239.0
SPTAN1	8260.0	8609.0
SPTB	-6634.0	4889.0
SPTBN1	6293.0	8597.0
SPTBN2	-7031.0	-7299.0
SPTBN4	-2861.0	-4447.0
SPTBN5	-4626.0	2022.0
SRD5A3	-8063.0	5781.0
SRP14	-5415.0	1924.0
SRP19	2724.0	606.0
SRP54	-154.0	-1827.0
SRP68	-3864.0	6022.0
SRP72	5178.0	-7566.0
SRP9	7641.0	1588.0
SRPRA	357.0	3889.0
SRPRB	-780.0	-5597.0
SSR1	-7224.0	-7967.0
SSR2	8097.0	-5033.0
SSR3	3605.0	1743.0
SSR4	5121.0	3488.0
ST3GAL1	6987.0	7996.0
ST3GAL2	4333.0	-2700.0
ST3GAL3	-5728.0	5532.0
ST3GAL4	7059.0	1405.0
ST3GAL5	8367.0	6852.0
ST3GAL6	2913.0	2671.0
ST6GAL1	-8163.0	-7517.0
ST6GALNAC1	415.0	-4335.0
ST6GALNAC2	-5721.0	6501.0
ST6GALNAC3	-4238.0	-7533.0
ST6GALNAC4	-2014.0	7002.0
ST6GALNAC5	5137.0	-2516.0
ST6GALNAC6	5424.5	6818.5
ST8SIA1	5227.0	-2837.0
ST8SIA3	397.0	-6216.0
ST8SIA4	-3138.0	-375.0
ST8SIA5	7835.0	-1114.0
ST8SIA6	2133.0	-6106.0
STAG1	7956.0	-8217.0
STAG2	5919.0	-7293.0
STAM	-5733.0	-1531.0
STAM2	-549.0	-1782.0
STAMBP	1696.0	3828.0
STAMBPL1	6931.0	-2722.0
STAT3	-7099.0	5958.0
STC2	3594.0	3080.0
STS	-6850.0	7710.0
STT3A	8065.0	-6249.0
STX17	-6509.0	-3627.0
STX1A	-421.0	-7172.0
STX5	-6976.0	-1923.0
SUDS3	1117.0	3749.0
SULT1A3	-2105.5	8200.5
SUMF1	-4471.0	2597.0
SUMO1	1735.0	-346.0
SUMO2	-3443.0	-5439.0
SUMO3	-5255.0	561.0
SUZ12	1841.0	-3053.0
SYVN1	-5712.0	7586.0
TAB1	-5854.0	3142.0
TADA2B	-1518.0	3579.0
TADA3	1780.0	5323.0
TAF10	5176.0	6868.0
TAF9B	6616.0	-3374.0
TARS1	7437.0	3698.0
TARS2	-5883.0	5290.0
TATDN2	6676.5	7420.5
TBC1D20	-552.0	4513.0
TBCA	2667.0	-5881.0
TBCB	2200.0	4897.0
TBCC	4582.0	-1539.0
TBCD	1513.0	8342.0
TBCE	7819.5	-7405.5
TCF7L2	-3983.0	-2771.0
TCP1	-6935.0	-3688.0
TDG	4655.0	-7859.0
TECTA	7042.0	7975.0
TECTB	-1753.0	1732.0
TFAP2A	-3465.0	-434.0
TFAP2B	-6982.0	4681.0
TFG	5882.0	-5187.0
TFPT	-2214.0	1904.0
TGFA	-939.0	-7373.0
TGFB1	-1002.0	-1450.0
TGFBI	-576.0	-897.0
TGFBR1	6837.0	-6198.0
TGFBR2	3599.0	5798.0
TGOLN2	-1716.0	-3675.0
THBS1	8333.0	-2377.0
THBS2	7494.0	-6330.0
THRA	-4384.0	-6626.0
THRB	8079.0	4565.0
THSD1	-1229.0	4520.0
THSD7A	-7585.0	-6238.0
THSD7B	-5535.0	6656.0
THY1	7236.0	-2933.0
TIMP1	-1091.0	-2604.0
TLN1	-4861.0	4596.0
TMED10	2747.0	3066.0
TMED2	-6292.0	174.0
TMED3	5832.0	-3371.0
TMED7	641.0	-6067.0
TMED9	5340.0	-1814.0
TMEM115	4966.0	6861.0
TMEM129	-4398.0	3774.0
TMEM132A	4909.0	5646.0
TNC	7222.0	-5800.0
TNFAIP3	-7045.0	6507.0
TNIP1	-8487.0	8375.0
TNIP2	-2878.0	7130.0
TNIP3	-4245.0	3635.0
TNKS	6736.0	-5982.0
TNKS2	-6786.0	-2463.0
TOMM20	15.0	3071.0
TOMM70	2750.0	2724.0
TOP1	-4901.0	8450.0
TOP2A	-2480.0	-8362.0
TOPORS	-4975.0	-3109.0
TP53BP1	4588.0	4104.0
TPGS1	-3462.0	6669.0
TPGS2	7708.0	-2713.0
TPP1	-2243.0	3007.0
TPR	-186.0	2533.0
TPST1	8492.0	-8519.0
TPST2	2244.0	-2162.0
TRAF2	1424.0	6511.0
TRAF3	7063.0	5059.0
TRAF6	-1959.0	-329.0
TRAM1	8055.0	-6456.0
TRAPPC1	8362.0	2272.0
TRAPPC10	-1837.5	5990.5
TRAPPC2L	-7656.0	5561.0
TRAPPC3	-1819.0	-2703.0
TRAPPC4	7829.0	5998.0
TRAPPC5	-2624.0	6642.0
TRAPPC6A	-5813.0	6465.0
TRAPPC6B	6078.0	2316.0
TRAPPC9	-8443.0	5047.0
TRIM13	7918.0	-988.0
TRIM25	-4941.0	-976.0
TRIM27	3311.0	1054.0
TRIM28	-88.0	2467.0
TRMT112	-4378.0	-4723.0
TSFM	-4767.0	7637.0
TSHB	-5052.0	2159.0
TSPAN14	1811.0	-5257.0
TSPAN15	-4088.0	2495.0
TSPAN33	4969.0	1426.0
TSPAN5	3022.0	1615.0
TSPYL2	3827.0	-8363.0
TTF1	3489.0	1878.0
TTL	6396.0	7231.0
TTLL1	-7489.0	-6370.0
TTLL10	-1901.0	-3313.0
TTLL11	-6553.0	-2893.0
TTLL12	5205.0	2410.0
TTLL13P	-7314.5	4708.5
TTLL3	-5791.5	1953.5
TTLL4	-4970.0	566.0
TTLL5	4473.0	-7212.0
TTLL6	1450.0	2836.0
TTLL7	6106.0	8272.0
TTLL8	7358.0	5529.0
TTLL9	-8557.0	8825.0
TTR	-8563.0	-2206.0
TUBA1A	3071.0	-6948.0
TUBA1B	-3197.0	3401.0
TUBA3E	3498.0	-1048.0
TUBA4A	-2394.0	7875.0
TUBA8	-3268.0	7511.0
TUBB1	-3031.0	-2231.0
TUBB2A	-3737.0	-7678.0
TUBB2B	6697.0	-8191.0
TUBB3	6238.5	746.5
TUBB4A	-2758.0	-4165.0
TUBB4B	-995.0	4111.0
TUBB6	531.0	-3508.0
TUFM	-106.0	7295.0
TULP4	-1802.0	-2245.0
TUSC3	7909.0	-8086.0
TXN	4635.0	-1043.0
UAP1	6416.0	497.0
UBA1	-4507.0	6703.0
UBA2	-4323.0	-5205.0
UBA3	5442.0	1674.0
UBA52	-1940.0	7240.0
UBA6	-3143.0	-4830.0
UBC	-6162.0	94.0
UBD	6539.0	-4467.0
UBE2A	-8532.0	-6226.0
UBE2B	-811.0	-3443.0
UBE2C	-6020.0	-7428.0
UBE2D1	-1110.0	3081.0
UBE2D2	1743.0	119.0
UBE2D3	-7793.0	7072.0
UBE2E1	-6675.0	-5377.0
UBE2F	8226.5	1983.5
UBE2G1	-3022.0	5045.0
UBE2G2	-6433.0	6900.0
UBE2H	-7598.0	-2335.0
UBE2I	3358.0	-871.0
UBE2J2	-302.0	6002.0
UBE2K	1125.0	-2223.0
UBE2L6	6949.0	-5337.0
UBE2M	951.0	7259.0
UBE2N	3842.5	3787.5
UBE2Q2	-749.0	-2085.0
UBE2R2	-4756.0	7858.0
UBE2S	-5413.0	5708.0
UBE2T	1087.0	-7466.0
UBE2V2	-1964.0	-5375.0
UBE2W	-5440.5	-2862.5
UBE2Z	6346.0	-3843.0
UBXN1	-530.0	6341.0
UBXN7	7927.0	-6746.0
UCHL1	4954.0	-3079.0
UCHL3	-1605.0	-4054.0
UCHL5	-1993.0	1699.0
UCN	5311.0	-1044.0
UGGT1	2649.0	1941.0
UHRF2	810.0	-1734.0
UIMC1	-6823.0	7232.0
UMOD	-1377.0	810.5
USO1	-41.0	5117.0
USP10	-5417.0	3778.0
USP11	-6482.0	4108.0
USP12	-8193.0	5313.0
USP13	1864.0	6883.0
USP14	-3271.0	5010.0
USP15	6879.0	8111.0
USP16	6437.0	3357.0
USP18	-6573.5	-2131.5
USP19	-5888.0	7462.0
USP2	-8157.0	8661.0
USP20	-8006.0	8644.0
USP21	-6026.0	6346.0
USP22	-6545.0	-1973.0
USP24	-194.0	4499.0
USP25	6660.0	8353.0
USP28	4076.0	-1158.0
USP3	-3709.0	-2364.0
USP30	-7166.0	7213.0
USP33	-108.0	-1878.0
USP34	3718.0	-2472.0
USP37	3682.0	-5988.0
USP4	-7997.0	8271.0
USP42	-2706.0	-5473.0
USP44	5815.0	-1743.0
USP47	-3614.0	5898.0
USP48	3375.0	7569.0
USP49	-2086.0	3550.0
USP5	4051.0	7386.0
USP7	3110.0	-5028.0
USP8	-1621.0	1217.0
USP9X	-1880.0	-2686.0
VAMP2	-6761.5	-121.5
VARS1	-4791.0	8791.0
VARS2	-7094.0	8753.0
VBP1	-6238.0	2086.0
VCAN	7513.0	-7936.0
VCP	-3107.0	6482.0
VCPIP1	1760.0	-3713.0
VDAC1	-3136.0	4155.0
VDAC2	1638.0	6094.0
VDAC3	-138.0	2845.0
VDR	-669.0	6870.0
VGF	5199.0	1274.0
VHL	4817.0	-4547.0
VNN1	6290.0	-598.0
VNN3	-7465.0	-7524.0
VWA1	2539.0	-6439.0
WAC	-1813.0	7481.0
WARS1	6568.0	7737.0
WARS2	-6764.0	-3139.0
WDR20	8113.0	490.0
WDR48	-6235.0	3938.0
WDR5	10.0	3502.0
WDR61	-3489.0	-2909.0
WDTC1	-5665.0	3459.0
WFS1	-1234.0	7864.0
WIPI1	-1415.0	6516.0
WRAP53	3794.0	8173.0
WRN	6861.0	-3981.0
WSB1	-1433.0	-7379.0
WSB2	5526.0	4659.0
XBP1	-6367.0	2310.0
XPC	836.0	4344.0
XPNPEP2	-6469.0	-3080.0
XRCC4	5539.0	1353.0
XRN2	3994.0	-5326.0
YARS1	917.0	4152.0
YARS2	-936.0	-1237.0
YIF1A	3862.0	8392.0
YKT6	7044.0	-4358.0
YOD1	5836.0	2178.0
YY1	2156.0	2313.0
ZBTB16	-6270.0	-1645.0
ZBTB17	-6163.0	8381.0
ZDHHC2	4152.0	1119.0
ZNF131	8356.0	-6163.0
ZRANB1	6385.0	2239.0

---

---

Autophagy

Autophagy

metric	value
setSize	122
pMANOVA	1.77e-10
p.adjustMANOVA	2.83e-08
s.dist	0.352
s.skel	-0.0448
s.heart	0.35
p.skel	0.393
p.heart	2.57e-11

Top 20 genes

Gene	skel	heart
CSNK2B	-8515.0	8824.0
PARK7	-8340.0	8811.0
TSC2	-8065.0	8707.0
IFT88	-7980.0	8627.0
MAP1LC3B	-8153.5	8186.5
MTMR3	-7905.0	8298.0
PINK1	-7552.0	8397.0
NBR1	-7939.0	7413.0
MFN2	-6960.0	8451.0
USP30	-7166.0	7213.0
SQSTM1	-5057.0	8580.0
ATG4B	-5760.0	7380.0
GABARAPL1	-7525.0	5491.0
ATG5	-7194.0	5130.0
VPS28	-5885.0	5945.0
PRKAB1	-6055.0	5660.0
CHMP6	-7417.0	4546.0
WIPI2	-4838.0	6505.0
HDAC6	-6881.0	4275.0
DYNC1I2	-5706.0	5083.0

Click HERE to show all gene set members

All member genes

	skel	heart
AMBRA1	-8497.0	-2866.0
ARL13B	7232.0	8489.0
ATG10	-1336.0	7618.0
ATG101	8063.0	6483.0
ATG12	2688.0	5077.0
ATG13	2170.0	2128.0
ATG14	679.0	-1285.0
ATG16L1	8400.0	8420.0
ATG3	6778.0	-7870.0
ATG4A	-255.0	3092.0
ATG4B	-5760.0	7380.0
ATG4C	5981.0	4403.0
ATG4D	7814.0	7731.0
ATG5	-7194.0	5130.0
ATG7	2503.0	-150.0
ATG9A	-5830.0	4522.0
ATG9B	7405.0	-3330.0
ATM	8167.0	-4787.0
BECN1	-5333.0	-7409.0
CETN1	1909.0	-2349.0
CFTR	1846.0	333.0
CHMP2A	-2015.0	153.0
CHMP2B	2625.0	5382.0
CHMP3	1021.5	5988.5
CHMP4B	-4052.0	4975.0
CHMP4C	4158.0	5907.0
CHMP6	-7417.0	4546.0
CHMP7	7382.0	7804.0
CSNK2A1	1817.5	4970.5
CSNK2A2	-5978.0	-4520.0
CSNK2B	-8515.0	8824.0
DYNC1H1	7671.0	6805.0
DYNC1I1	5105.0	2652.0
DYNC1I2	-5706.0	5083.0
DYNC1LI1	6461.0	7025.0
DYNC1LI2	4553.0	-2293.0
DYNLL1	1967.0	754.0
DYNLL2	-3336.0	6037.0
EEF1A1	4479.0	-3572.0
EPAS1	-6815.0	3574.0
FUNDC1	5940.0	1799.0
GABARAP	4917.0	3037.0
GABARAPL1	-7525.0	5491.0
GABARAPL2	3303.0	491.0
GFAP	-8679.0	-7657.0
HDAC6	-6881.0	4275.0
HSF1	-3651.0	1899.0
HSP90AB1	-2904.0	8328.0
HSPA8	382.0	7793.0
IFT88	-7980.0	8627.0
LAMP2	1197.0	-4151.0
LAMTOR1	1538.0	5698.0
LAMTOR2	6759.0	7981.0
LAMTOR3	2898.0	3567.0
LAMTOR4	6737.0	5739.0
LAMTOR5	-7085.0	-1730.0
MAP1LC3A	4067.0	5098.0
MAP1LC3B	-8153.5	8186.5
MFN1	6282.0	7683.0
MFN2	-6960.0	8451.0
MLST8	-3215.0	524.0
MTERF3	-5797.0	-1900.0
MTMR14	-1824.0	6421.0
MTMR3	-7905.0	8298.0
MTOR	3277.0	8262.0
MVB12A	-1768.0	6228.0
MVB12B	-6566.0	1697.0
NBR1	-7939.0	7413.0
PARK7	-8340.0	8811.0
PCNT	-6585.0	2600.0
PEX5	4433.0	-256.0
PGAM5	2963.0	139.0
PIK3C3	5209.0	7133.0
PIK3R4	3914.0	1845.0
PINK1	-7552.0	8397.0
PLIN2	-803.0	6441.0
PLIN3	-626.0	7418.0
PRKAA1	3192.0	-7129.0
PRKAA2	4171.0	6123.0
PRKAB1	-6055.0	5660.0
PRKAB2	-128.0	8793.0
PRKAG2	-1682.0	-732.0
PRKAG3	-3862.0	2949.0
RB1CC1	6316.0	-749.0
RHEB	3445.0	4542.0
RNASE1	-4306.0	1444.0
RPS27A	7076.0	2193.0
RPTOR	-5074.0	5182.0
RRAGA	1911.0	1066.0
RRAGB	-4446.0	-2305.0
RRAGC	3850.0	4236.0
RRAGD	858.0	2887.0
SLC38A9	6349.0	-6219.0
SQSTM1	-5057.0	8580.0
SRC	-7820.0	-2286.0
TOMM20	15.0	3071.0
TOMM22	3929.0	2851.0
TOMM40	1301.0	8216.0
TOMM6	1744.0	6131.0
TOMM7	1025.0	-4848.0
TOMM70	2750.0	2724.0
TSC1	-5152.0	1619.0
TSC2	-8065.0	8707.0
TSG101	-6893.0	377.0
UBA52	-1940.0	7240.0
UBAP1	-5816.0	4634.0
UBC	-6162.0	94.0
UBE2N	3842.5	3787.5
ULK1	-3344.0	450.0
USP30	-7166.0	7213.0
UVRAG	3216.0	-5061.0
VCP	-3107.0	6482.0
VDAC1	-3136.0	4155.0
VPS28	-5885.0	5945.0
VPS37A	-3776.0	-109.0
VPS37B	-3959.0	-5269.0
VPS37C	1162.0	8324.0
VPS37D	7210.0	-4144.0
WDR45	309.0	6499.0
WDR45B	3755.0	2661.0
WIPI1	-1415.0	6516.0
WIPI2	-4838.0	6505.0

---

---

Xenobiotics

Xenobiotics

metric	value
setSize	20
pMANOVA	3.53e-10
p.adjustMANOVA	5.09e-08
s.dist	0.84
s.skel	-0.676
s.heart	-0.499
p.skel	1.67e-07
p.heart	0.000113

Top 20 genes

Gene	skel	heart
CYP2A13	-8779.0	-8513.0
CYP2A6	-8779.0	-8513.0
CYP2A7	-8779.0	-8513.0
CYP2E1	-8721.0	-7546.0
CYP3A4	-8713.0	-7493.0
CYP3A43	-8713.0	-7493.0
CYP3A5	-8713.0	-7493.0
CYP3A7	-8713.0	-7493.0
ARNT	-8699.0	-4889.0
CYP2C18	-7648.5	-4678.5
AHRR	-8412.0	-1265.0
CYP2S1	-1435.0	-6629.0
CYP2W1	-3685.0	-1050.0
CYP2J2	-214.0	-7865.0

Click HERE to show all gene set members

All member genes

	skel	heart
AHR	2676.5	-7376.5
AHRR	-8412.0	-1265.0
ARNT	-8699.0	-4889.0
ARNT2	1293.0	-3805.0
CYP1A1	253.0	3185.0
CYP1A2	-6527.0	3994.0
CYP2A13	-8779.0	-8513.0
CYP2A6	-8779.0	-8513.0
CYP2A7	-8779.0	-8513.0
CYP2C18	-7648.5	-4678.5
CYP2D6	-8757.5	3160.5
CYP2E1	-8721.0	-7546.0
CYP2F1	-8216.0	6520.0
CYP2J2	-214.0	-7865.0
CYP2S1	-1435.0	-6629.0
CYP2W1	-3685.0	-1050.0
CYP3A4	-8713.0	-7493.0
CYP3A43	-8713.0	-7493.0
CYP3A5	-8713.0	-7493.0
CYP3A7	-8713.0	-7493.0

---

---

Protein localization

Protein localization

metric	value
setSize	156
pMANOVA	4.73e-10
p.adjustMANOVA	6.2e-08
s.dist	0.305
s.skel	-0.0183
s.heart	0.304
p.skel	0.694
p.heart	5.75e-11

Top 20 genes

Gene	skel	heart
PEX16	-8047	8850
LONP2	-8225	8600
BAG6	-8564	8228
ACOX1	-6504	8563
PXMP2	-8184	6792
UBE2D3	-7793	7072
CRAT	-6337	8478
SLC25A12	-6950	7548
GET1	-7383	6494
PEX10	-5618	8104
FXN	-5533	8213
PITRM1	-4455	8346
SGTA	-4622	7821
PXMP4	-7685	4263
ABCD1	-4268	6911
PMPCB	-4835	6077
HSPD1	-4013	5490
CAT	-5822	3647
SEC61G	-2606	8052
PEX19	-2410	8332

Click HERE to show all gene set members

All member genes

	skel	heart
ABCD1	-4268.0	6911.0
ABCD2	-525.0	4969.0
ABCD3	6228.0	6142.0
ACAA1	-3192.0	2568.0
ACBD5	-8421.0	-5725.0
ACO2	769.0	8700.0
ACOT2	2480.5	5274.5
ACOT4	5223.0	-6234.0
ACOT8	5477.0	7974.0
ACOX1	-6504.0	8563.0
ACOX2	5177.0	5092.0
ACOX3	-5710.0	2312.0
AGPS	1945.0	-4420.0
AGXT	-6641.0	-1419.0
ALDH3A2	-2840.0	-4223.0
AMACR	3765.0	8481.0
APP	7187.0	7687.0
ATP5F1A	-1377.0	-5931.0
ATP5F1B	-1494.0	4951.0
BAAT	-8128.0	-6570.0
BAG6	-8564.0	8228.0
BCS1L	986.0	3616.0
CAMLG	-4566.0	-1115.0
CAT	-5822.0	3647.0
CHCHD10	-7909.0	-7733.0
CHCHD2	-7452.0	-7800.0
CHCHD3	1874.0	4935.0
CHCHD4	8044.0	5901.0
CHCHD5	6978.0	7415.0
CHCHD7	107.0	1365.0
CMC2	7233.0	8457.0
CMC4	-5763.0	968.0
COA4	5973.0	2971.0
COA6	-371.0	1175.0
COQ2	-1090.0	5249.0
COX17	3223.0	636.0
COX19	-2652.0	-1153.0
CRAT	-6337.0	8478.0
CROT	-8523.0	-5984.0
CS	1762.0	5778.0
CYB5A	-1290.0	689.0
CYC1	1643.0	5325.0
DAO	-7904.0	-1143.0
DDO	-2962.0	-5899.0
DHRS4	-1304.5	6275.5
DNAJC19	4885.0	-268.0
ECH1	1802.0	5263.0
ECI2	8370.0	8604.0
EHHADH	-493.0	3887.0
EMD	4418.0	4093.0
EPHX2	6259.0	-5095.0
FXN	-5533.0	8213.0
GDAP1	2598.0	6147.0
GET1	-7383.0	6494.0
GET3	4528.0	8134.0
GET4	1716.0	-5434.0
GFER	-2919.0	-4518.0
GNPAT	2380.0	1238.0
GRPEL1	3735.0	7537.0
GRPEL2	-4212.0	-4168.0
GSTK1	-2940.0	-5138.0
HACL1	626.0	-2726.0
HAO1	-2762.0	6279.0
HAO2	4933.0	6926.0
HMGCL	3044.0	3800.0
HMOX1	838.0	6054.0
HSCB	4363.0	-4640.0
HSD17B4	4640.0	8400.0
HSPA9	520.0	4996.0
HSPD1	-4013.0	5490.0
IDE	-7664.0	-264.0
IDH1	645.0	6338.0
IDH3G	-2889.0	2505.0
LDHD	-733.0	8640.0
LONP2	-8225.0	8600.0
MLYCD	3424.0	7970.0
MPV17	-6927.0	-534.0
MTX1	5807.0	6464.0
MTX2	6517.0	933.0
NDUFB8	2773.5	4506.5
NOS2	-7498.0	-6811.0
NUDT19	5874.0	6437.0
NUDT7	8148.0	-6709.0
OTC	-2319.0	3700.0
OTOF	5624.0	-1414.0
PAM16	5166.0	1858.0
PAOX	-1449.5	7587.5
PECR	7288.0	8280.0
PEX1	9.0	5975.0
PEX10	-5618.0	8104.0
PEX11B	6459.0	-3608.0
PEX12	-7360.0	-237.0
PEX13	-6359.0	-2647.0
PEX14	2806.0	6149.0
PEX16	-8047.0	8850.0
PEX19	-2410.0	8332.0
PEX2	5254.0	3552.0
PEX26	-2499.0	6716.0
PEX3	-7767.0	-4560.0
PEX5	4433.0	-256.0
PEX6	-764.0	2278.0
PEX7	4124.0	4489.0
PHYH	-1794.0	7155.0
PIPOX	-7344.0	-2969.0
PITRM1	-4455.0	8346.0
PMPCA	609.0	8054.0
PMPCB	-4835.0	6077.0
PRNP	-821.0	759.0
PXMP2	-8184.0	6792.0
PXMP4	-7685.0	4263.0
RPS27A	7076.0	2193.0
SAMM50	3305.0	6012.0
SEC61B	2781.0	-5229.0
SEC61G	-2606.0	8052.0
SERP1	5857.0	-3039.0
SGTA	-4622.0	7821.0
SLC25A12	-6950.0	7548.0
SLC25A13	4690.0	7555.0
SLC25A17	-1247.0	3124.0
SLC25A4	6364.0	5152.0
SLC27A2	-8616.0	-1781.0
STX1A	-421.0	-7172.0
STX5	-6976.0	-1923.0
TAZ	3849.0	5446.0
TIMM10	6441.0	5201.0
TIMM10B	8059.5	4982.5
TIMM13	4041.0	27.0
TIMM17A	601.0	3894.0
TIMM17B	-8629.0	-6611.0
TIMM21	1987.0	5940.0
TIMM22	6328.0	3738.0
TIMM23	-2361.0	6121.0
TIMM44	5188.0	7023.0
TIMM50	3581.0	8796.0
TIMM8A	3221.0	6068.0
TIMM8B	7528.0	5682.0
TIMM9	-2087.0	1293.0
TOMM20	15.0	3071.0
TOMM22	3929.0	2851.0
TOMM40	1301.0	8216.0
TOMM6	1744.0	6131.0
TOMM7	1025.0	-4848.0
TOMM70	2750.0	2724.0
TYSND1	-1332.0	4712.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
UBE2D1	-1110.0	3081.0
UBE2D2	1743.0	119.0
UBE2D3	-7793.0	7072.0
UBE2J2	-302.0	6002.0
UBL4A	-401.0	5383.0
USP9X	-1880.0	-2686.0
VAMP2	-6761.5	-121.5
VAPA	6672.0	-6441.0
VDAC1	-3136.0	4155.0
ZFAND6	-5319.0	-1299.0

---

---

Respiratory electron transport

Respiratory electron transport

metric	value
setSize	95
pMANOVA	1.47e-09
p.adjustMANOVA	1.76e-07
s.dist	0.375
s.skel	0.149
s.heart	0.344
p.skel	0.012
p.heart	7.2e-09

Top 20 genes

Gene	skel	heart
ACAD9	7631.0	7946.0
NDUFA8	5987.0	8490.0
NDUFA2	7987.0	5613.0
COX11	5457.0	7979.0
NDUFA6	5924.0	5771.0
TIMMDC1	4421.0	7069.0
NDUFAB1	6473.0	4242.0
COX18	5469.0	4656.0
NDUFB9	4566.0	5421.0
NDUFA7	5691.5	3873.5
NDUFAF7	7863.0	2760.0
UQCR10	5657.0	3744.0
NDUFV2	3291.0	6011.0
NDUFC1	6283.0	3026.0
ETFA	3199.0	5540.0
NDUFS8	2854.0	5403.0
NDUFS3	2309.0	6202.0
UQCRH	2930.5	4859.5
UQCRQ	3103.0	4519.0
NDUFA12	1609.0	8560.0

Click HERE to show all gene set members

All member genes

	skel	heart
ACAD9	7631.0	7946.0
COQ10A	-6941.0	-2064.0
COQ10B	-149.0	2833.0
COX11	5457.0	7979.0
COX14	2222.0	3423.0
COX16	-1973.0	-7786.0
COX18	5469.0	4656.0
COX19	-2652.0	-1153.0
COX20	2493.0	669.0
COX4I1	2872.0	3827.0
COX5A	3962.0	473.0
COX5B	-1445.0	5794.0
COX6A1	844.0	1034.0
COX6B1	2433.0	-5248.0
COX7A2L	-4533.0	6293.0
COX7B	4671.0	2669.0
COX7C	4843.0	-2111.0
COX8A	2020.0	-4946.0
CYC1	1643.0	5325.0
ECSIT	-2263.0	8037.0
ETFA	3199.0	5540.0
ETFB	-2415.0	6029.0
ETFDH	-352.0	7165.0
MT-CO1	-2993.0	7342.0
MT-CO2	-2478.0	6828.0
MT-CO3	2221.0	1527.0
MT-CYB	-2903.0	1337.0
MT-ND1	-3770.0	2451.0
MT-ND2	-783.0	299.0
MT-ND3	-3514.0	1797.0
MT-ND4	-3963.0	382.0
MT-ND5	-4600.0	1285.0
MT-ND6	-4778.0	-754.0
NDUFA1	7797.0	-3580.0
NDUFA10	-377.0	5987.0
NDUFA11	662.5	4964.5
NDUFA12	1609.0	8560.0
NDUFA13	-81.0	7199.0
NDUFA2	7987.0	5613.0
NDUFA3	2870.0	2229.0
NDUFA4	3762.0	1226.0
NDUFA5	676.0	3420.0
NDUFA6	5924.0	5771.0
NDUFA7	5691.5	3873.5
NDUFA8	5987.0	8490.0
NDUFA9	1104.0	3610.0
NDUFAB1	6473.0	4242.0
NDUFAF1	-2181.0	2883.0
NDUFAF3	-2409.0	6988.0
NDUFAF4	125.0	6668.0
NDUFAF5	-2715.0	1947.0
NDUFAF6	-2930.0	-2683.0
NDUFAF7	7863.0	2760.0
NDUFB10	-1877.0	6302.0
NDUFB11	7357.0	-361.0
NDUFB2	-2642.0	4479.0
NDUFB3	7684.0	-3453.0
NDUFB4	-7278.0	-3860.0
NDUFB5	3542.0	1027.0
NDUFB6	3414.0	3235.0
NDUFB7	-2445.0	2370.0
NDUFB8	2773.5	4506.5
NDUFB9	4566.0	5421.0
NDUFC1	6283.0	3026.0
NDUFC2	781.5	2587.5
NDUFS1	119.0	2981.0
NDUFS2	-1004.0	6854.0
NDUFS3	2309.0	6202.0
NDUFS4	4055.0	2334.0
NDUFS5	-2600.0	8309.0
NDUFS6	7811.0	-2761.0
NDUFS7	-2856.0	7757.0
NDUFS8	2854.0	5403.0
NDUFV1	-133.0	6803.0
NDUFV2	3291.0	6011.0
NDUFV3	8473.0	-6717.0
NUBPL	4558.0	-1135.0
SCO1	-1140.0	6877.0
SDHA	-1653.5	4126.5
SDHB	1308.0	6790.0
SDHC	1049.0	4498.0
SDHD	-257.5	2208.5
SURF1	818.0	5283.0
TACO1	1469.0	7286.0
TIMMDC1	4421.0	7069.0
TMEM126B	2822.0	-2468.0
TRAP1	-3817.0	7194.0
UQCR10	5657.0	3744.0
UQCR11	-3327.5	2636.5
UQCRB	7471.0	-7671.0
UQCRC1	-746.0	6208.0
UQCRC2	686.0	3409.0
UQCRFS1	-512.0	6119.0
UQCRH	2930.5	4859.5
UQCRQ	3103.0	4519.0

---

---

Metabolism

Metabolism

metric	value
setSize	1930
pMANOVA	8.45e-09
p.adjustMANOVA	9.37e-07
s.dist	0.0856
s.skel	-0.0263
s.heart	0.0815
p.skel	0.0595
p.heart	4.89e-09

Top 20 genes

Gene	skel	heart
ELOVL1	-8733.0	8830.0
PPT2	-8701.5	8841.5
CSNK2B	-8515.0	8824.0
AKR1B10	-8633.0	8691.0
CES2	-8781.0	8525.0
PLA2G6	-8745.0	8367.0
MED16	-8264.0	8766.0
PARP4	-8531.0	8476.0
UGT2A3	-8356.0	8558.0
PLCB4	-8101.0	8738.0
BPGM	-8401.0	8289.0
STARD10	-8488.0	8192.0
PFKFB2	-8322.0	8320.0
CYP4F8	-8762.0	7837.0
RXRB	-7681.0	8892.0
SLC19A1	-8015.0	8483.0
GLDC	-8029.0	8465.0
INPP4B	-7765.0	8612.0
PDP1	-7819.0	8521.0
BBOX1	-7690.0	8647.0

Click HERE to show all gene set members

All member genes

	skel	heart
AAAS	-438.0	7079.0
AACS	-6701.0	6103.0
AADAC	365.0	65.0
AADAT	-8663.0	-277.0
AANAT	-372.0	-905.0
AASDHPPT	5139.0	-216.0
AASS	-234.0	-7720.0
ABCA1	-5829.0	-5026.0
ABCB11	-7464.0	-1458.0
ABCB4	8253.0	8852.0
ABCB7	6072.0	3682.0
ABCC1	-5071.0	97.0
ABCC2	-7018.0	4203.0
ABCC3	-8425.0	-8337.0
ABCC5	-6627.0	-8230.0
ABCC8	7973.0	6381.0
ABCD1	-4268.0	6911.0
ABCD4	-5217.0	1069.0
ABCG2	8493.0	-8359.0
ABHD10	8549.0	7553.0
ABHD14B	-6867.0	1382.0
ABHD3	2731.0	-5230.0
ABHD4	20.0	5278.0
ABHD5	1462.0	3091.0
ABO	1947.0	7951.0
ACAA1	-3192.0	2568.0
ACAA2	-755.0	8275.0
ACACA	-8612.0	698.0
ACACB	-7967.0	5264.0
ACAD10	-6953.0	4446.0
ACAD11	-6861.0	4176.0
ACAD8	968.0	-390.0
ACAD9	7631.0	7946.0
ACADL	-569.0	4303.0
ACADM	-1240.0	6598.0
ACADS	3790.0	7879.0
ACADSB	-5210.0	-1834.0
ACADVL	2074.0	6681.0
ACAN	6744.0	4680.0
ACAT1	-3035.0	5241.0
ACAT2	4858.0	-8509.0
ACBD4	-2036.0	5033.0
ACBD5	-8421.0	-5725.0
ACBD6	3601.0	7320.0
ACBD7	-1414.0	4844.0
ACER1	-6676.0	4065.0
ACER2	-1923.0	-1813.0
ACER3	3712.0	-4105.0
ACHE	-8693.0	-2707.0
ACLY	1600.0	-4958.0
ACMSD	-5833.0	2373.0
ACO2	769.0	8700.0
ACOT1	2480.5	5274.5
ACOT11	-1586.0	5683.0
ACOT12	-2653.0	-3316.0
ACOT13	3860.0	3992.0
ACOT2	2480.5	5274.5
ACOT4	5223.0	-6234.0
ACOT6	-8068.0	-1577.0
ACOT7	-1142.0	5543.0
ACOT8	5477.0	7974.0
ACOT9	3440.0	1629.0
ACOX1	-6504.0	8563.0
ACOX2	5177.0	5092.0
ACOX3	-5710.0	2312.0
ACOXL	-6471.0	8072.0
ACP5	8061.0	8294.0
ACP6	-1933.0	7327.0
ACSBG1	-6944.0	-2820.0
ACSBG2	-1674.0	-4583.0
ACSF2	-7301.0	3820.0
ACSF3	-633.0	2293.0
ACSL1	-2509.0	8266.0
ACSL3	5667.0	-5476.0
ACSL4	56.0	-7876.0
ACSL5	321.0	-2048.0
ACSL6	8386.5	8669.5
ACSM1	6418.0	-8070.0
ACSM3	4133.0	1985.0
ACSM4	-5777.0	6211.0
ACSM5	-6291.0	-8324.0
ACSS1	-7311.0	3803.0
ACSS2	-1908.0	1932.0
ACSS3	-7553.0	4803.0
ACY1	103.5	-524.5
ACY3	2844.0	2020.0
ADA	1954.0	-4805.0
ADAL	6859.0	2715.0
ADCY1	-3786.0	223.0
ADCY2	-6164.0	-5813.0
ADCY3	1385.0	-6913.0
ADCY4	-6488.0	1986.0
ADCY5	-2115.0	3615.0
ADCY6	-6611.0	275.0
ADCY7	1963.0	-3579.0
ADCY8	6532.0	4755.0
ADCY9	-1608.0	173.0
ADH5	2461.0	-8269.0
ADH7	-2303.0	-6566.0
ADHFE1	-4253.0	6327.0
ADI1	-2974.0	-6270.0
ADIPOQ	-8400.0	-7399.0
ADIPOR1	-1712.0	5503.0
ADIPOR2	-6799.0	6088.0
ADK	3482.0	8357.0
ADPGK	2687.0	-1234.0
ADPRM	5842.0	4460.0
ADRA2A	4300.0	3775.0
ADRA2C	4641.0	4450.0
ADSL	-5939.0	6145.0
AFMID	-2033.0	-3623.0
AGK	-6603.0	5733.0
AGL	1318.0	2186.0
AGMAT	4564.0	-4477.0
AGMO	-4973.0	-6282.0
AGPAT1	-7875.0	-7713.0
AGPAT2	-7254.0	5009.0
AGPAT3	120.0	-3564.0
AGPAT4	6962.0	3110.0
AGPAT5	6471.0	-6375.0
AGPS	1945.0	-4420.0
AGRN	-978.0	-4541.0
AGT	-7588.0	-5820.0
AGXT	-6641.0	-1419.0
AGXT2	-3885.0	-6810.0
AHCY	-3065.0	-2144.0
AHCYL1	7434.0	-3277.0
AHR	2676.5	-7376.5
AHRR	-8412.0	-1265.0
AIMP1	5901.0	2626.0
AIMP2	2900.0	7129.0
AIP	-5707.0	7246.0
AK1	-5985.0	8664.0
AK2	5168.0	5309.0
AK4	-3452.0	-872.0
AK5	-3269.0	4137.0
AK6	4983.0	-3706.0
AK7	-7310.0	6841.0
AK8	-5162.0	-6023.0
AK9	5299.0	-5045.0
AKAP5	3398.0	4466.0
AKR1A1	-768.0	4216.0
AKR1B1	4669.0	5374.0
AKR1B10	-8633.0	8691.0
AKR1D1	3446.0	-7798.0
AKR7A3	-6901.0	-4581.0
AKR7L	-7406.0	7924.0
AKT1	1272.0	5976.0
ALAD	-2641.0	8232.0
ALAS1	6276.0	8730.0
ALAS2	3038.0	3782.0
ALB	7676.0	-6428.0
ALDH18A1	2883.0	-3089.0
ALDH1A1	-3512.0	551.0
ALDH1B1	-4420.0	-1906.0
ALDH1L1	-2081.0	-4276.0
ALDH1L2	6454.0	-7799.0
ALDH2	-7548.5	-388.5
ALDH3A1	4542.0	3214.0
ALDH3A2	-2840.0	-4223.0
ALDH3B1	-3360.0	-6585.0
ALDH6A1	-7337.0	1913.0
ALDH7A1	537.0	4660.0
ALDOA	-7780.0	8378.0
ALDOB	-8709.0	2154.0
ALDOC	-8658.0	4671.0
ALOX12	5474.0	3171.0
ALOX15	2681.0	-1881.0
ALOX15B	-2018.0	3583.0
ALOX5	2483.0	-4648.0
ALOX5AP	-5115.0	-1559.0
ALOXE3	6216.0	4967.0
ALPI	-3249.0	-8109.0
AMACR	3765.0	8481.0
AMD1	6071.0	5558.0
AMDHD1	-1697.0	-3115.0
AMN	-1477.0	-5376.0
AMPD1	-2980.0	-2998.0
AMPD2	1737.0	5892.0
AMPD3	-2944.0	5048.0
AMT	-6656.5	3275.5
ANGPTL4	-5974.0	-5964.0
ANKRD1	8212.0	5087.0
AOC1	1250.0	-7924.0
AOC3	653.0	-4328.0
AOX1	-8021.0	-8040.0
APIP	-7778.0	6342.0
APOA1	-488.0	3512.0
APOA2	-7127.0	-5091.0
APOA4	-6487.0	-3735.0
APOA5	-8191.0	507.0
APOB	446.0	-8252.0
APOC2	-7258.5	203.5
APOC3	-8626.0	-7683.0
APOE	-8560.0	-6177.0
APOM	1430.0	-8376.0
APRT	4927.0	6234.0
ARF1	-6136.0	5121.0
ARG1	-6305.0	-4483.0
ARG2	-4109.0	663.0
ARNT	-8699.0	-4889.0
ARNT2	1293.0	-3805.0
ARNTL	976.0	-7699.0
ARSA	-4926.0	2825.0
ARSB	566.0	-4573.0
ARSG	21.0	-1189.0
ARSI	6330.0	-5272.0
ARSK	-1160.0	-1712.0
ARSL	3149.0	596.0
ARV1	5357.0	5338.0
AS3MT	-1467.0	-4266.0
ASAH1	8174.0	4046.0
ASAH2	-6735.0	8639.0
ASL	-6422.5	-3736.5
ASMT	383.0	1109.0
ASNS	7343.0	6787.0
ASPA	8532.0	7219.0
ASPG	-5369.0	267.0
ASRGL1	-4702.0	1073.0
ASS1	-7545.0	8712.0
ATIC	3913.0	5648.0
ATP5F1A	-1377.0	-5931.0
ATP5F1B	-1494.0	4951.0
ATP5F1D	-704.0	8523.0
ATP5F1E	5050.0	-1368.0
ATP5MC3	3773.0	312.0
ATP5ME	-4161.0	-3064.0
ATP5MF	2482.0	2566.0
ATP5MG	1185.5	-2613.5
ATP5PB	-6172.0	8413.0
ATP5PD	-68.0	3308.0
ATP5PF	-1793.0	-399.0
ATP5PO	2969.5	2847.5
AUH	5304.0	6618.0
AWAT2	7752.0	-7273.0
AZIN1	8220.0	2419.0
AZIN2	6512.0	4372.0
B3GALNT1	3985.0	-1830.0
B3GALT1	-5968.0	4010.0
B3GALT2	3459.0	-4286.0
B3GALT4	-905.0	3742.0
B3GALT5	2834.0	3260.0
B3GALT6	6790.0	622.0
B3GAT1	-7531.0	-6209.0
B3GAT2	3863.0	5034.0
B3GAT3	-2148.0	5868.0
B3GNT2	-2195.0	-6605.0
B3GNT3	8057.0	-473.0
B3GNT4	3532.0	4961.0
B3GNT7	-5577.0	-5188.0
B4GALNT1	2851.0	7600.0
B4GALT1	-2811.0	-4650.0
B4GALT2	5032.0	-1463.0
B4GALT3	-1947.0	2598.0
B4GALT4	2234.0	-6309.0
B4GALT5	4188.0	8099.0
B4GALT6	8566.0	-7661.0
B4GALT7	79.0	8430.0
B4GAT1	-3827.0	-2685.0
BAAT	-8128.0	-6570.0
BBOX1	-7690.0	8647.0
BCAN	-7508.0	4213.0
BCAT1	8375.0	-7772.0
BCAT2	-8258.0	5243.0
BCHE	-5321.0	-3661.0
BCKDHA	-4643.5	6268.5
BCKDHB	614.0	5097.0
BCKDK	4104.0	8308.0
BCO1	3610.0	-225.0
BCO2	5768.0	-7653.0
BDH1	4975.0	5378.0
BDH2	2577.0	1023.0
BGN	5498.0	-2960.0
BHMT	-7954.0	-1162.0
BHMT2	-7777.0	1936.0
BLVRA	6731.0	-5561.0
BLVRB	-6315.0	5636.0
BMX	-7098.0	4701.0
BPGM	-8401.0	8289.0
BPHL	4534.0	3725.0
BPNT1	102.0	8142.0
BPNT2	8420.0	-2657.0
BRIP1	1133.0	-6543.0
BSG	6138.0	8069.0
BST1	5015.0	-2795.0
BTD	-2746.0	1409.0
CA1	-2405.0	3258.0
CA12	2427.0	-2323.0
CA13	-3644.0	1329.0
CA14	-2008.0	7109.0
CA2	-2613.0	-1163.0
CA3	-6413.0	-4937.0
CA4	-4368.0	694.0
CA5A	5309.0	-6001.0
CA5B	-353.0	-2990.0
CA6	-4868.0	2642.0
CA7	-2010.0	715.0
CA9	-6379.0	-3337.0
CACNA1A	-6963.0	-2225.0
CACNA1C	8240.0	-8009.0
CACNA1D	6749.0	-7263.0
CACNA1E	8458.0	-8524.0
CACNA2D2	-6594.0	-1456.0
CACNB2	8555.0	1503.0
CACNB3	4967.0	-6047.0
CAD	3185.0	662.0
CALM1	-82.0	3278.0
CARM1	-5011.0	4672.0
CARNMT1	558.0	5486.0
CARNS1	7203.0	7316.0
CAV1	-1519.0	-5639.0
CBLIF	-5642.0	-3553.0
CBR3	-1377.0	3028.5
CBR4	-6047.0	1824.0
CBS	-8367.5	120.5
CBSL	-8367.5	120.5
CCNC	5527.0	-6239.0
CD320	6245.0	2868.0
CD36	-6975.0	-1857.0
CD38	-4043.0	-6171.0
CD44	5992.0	-7861.0
CDA	-1404.0	7453.0
CDIPT	5373.0	4504.0
CDK19	-2123.0	1498.0
CDO1	-8386.0	-4800.0
CDS1	-944.0	4715.0
CDS2	2264.0	3217.0
CEMIP	7974.0	-7446.0
CEPT1	5143.0	-4601.0
CERK	-4609.0	176.0
CERS1	-435.0	-3421.0
CERS2	-7693.0	-5722.0
CERS3	-519.0	-7714.0
CERS4	-7431.0	-6590.0
CERS5	-675.0	-7937.0
CERS6	-191.0	-7328.0
CERT1	2804.0	-2596.0
CES1	-8429.0	921.0
CES2	-8781.0	8525.0
CGA	-260.5	810.5
CH25H	-1773.0	-2253.0
CHAC1	-2932.0	-3398.0
CHAC2	5984.0	5322.0
CHD9	8392.0	-8195.0
CHDH	-5802.0	-6072.0
CHKA	-7536.0	2289.0
CHKB	872.0	2030.0
CHP1	-3392.0	3767.0
CHPF	7034.0	-836.0
CHPF2	7922.0	-3551.0
CHPT1	3284.0	904.0
CHRM3	-8036.0	-4250.0
CHST1	1751.0	-1802.0
CHST11	-1299.0	-7464.0
CHST12	-3717.0	-1308.0
CHST13	-2923.0	-5655.0
CHST14	-1622.0	-6478.0
CHST15	1788.0	8331.0
CHST2	-1875.0	-2482.0
CHST3	-7441.0	-6002.0
CHST7	3575.0	-2493.0
CHST9	2556.0	2014.0
CHSY1	6166.0	-3085.0
CHSY3	7412.0	-5084.0
CIAO1	1165.0	8291.0
CIAO2B	3835.0	6379.0
CIAO3	-1164.0	6898.0
CIAPIN1	5224.0	7491.0
CIDEA	1552.0	4502.0
CIDEC	-8619.0	-2126.0
CKB	7150.0	1443.0
CKM	-6521.0	5501.0
CKMT1A	6650.5	8526.5
CKMT2	5117.0	6895.0
CLOCK	-7334.0	-8511.0
CMBL	-6740.0	3768.0
CMPK1	7176.0	-6633.0
CNDP2	5752.0	2403.0
COASY	5618.0	-422.0
COMT	-6092.0	-2006.0
COQ10A	-6941.0	-2064.0
COQ10B	-149.0	2833.0
COQ2	-1090.0	5249.0
COQ3	3016.0	3759.0
COQ5	-1497.0	7767.0
COQ6	-4012.0	3521.0
COQ7	3182.0	8743.0
COQ9	-3369.0	7670.0
COX10	-1055.0	7634.0
COX11	5457.0	7979.0
COX14	2222.0	3423.0
COX16	-1973.0	-7786.0
COX18	5469.0	4656.0
COX19	-2652.0	-1153.0
COX20	2493.0	669.0
COX4I1	2872.0	3827.0
COX5A	3962.0	473.0
COX5B	-1445.0	5794.0
COX6A1	844.0	1034.0
COX6B1	2433.0	-5248.0
COX7A2L	-4533.0	6293.0
COX7B	4671.0	2669.0
COX7C	4843.0	-2111.0
COX8A	2020.0	-4946.0
CPNE1	2260.0	-3801.0
CPNE3	2445.0	-4470.0
CPNE6	-5451.0	-3828.0
CPNE7	-4189.0	8533.0
CPOX	-2202.0	-902.0
CPS1	8038.0	-8206.0
CPT1A	3118.0	5586.0
CPT1B	-4528.0	7379.0
CPT2	-2752.0	6685.0
CPTP	6809.0	6073.0
CRAT	-6337.0	8478.0
CREBBP	-5284.0	-2821.0
CRLS1	4130.0	-3181.0
CROT	-8523.0	-5984.0
CRYL1	828.0	-1727.0
CRYM	3144.0	4162.0
CS	1762.0	5778.0
CSAD	-8278.0	-2313.0
CSGALNACT1	-3115.0	3121.0
CSGALNACT2	2614.0	-4528.0
CSNK1G2	-8175.0	8012.0
CSNK2A1	1817.5	4970.5
CSNK2A2	-5978.0	-4520.0
CSNK2B	-8515.0	8824.0
CSPG4	-4274.0	-5233.0
CSPG5	-3045.0	-5989.0
CTH	-5201.0	682.0
CTPS1	699.0	5000.0
CTPS2	-2589.0	-7009.0
CTRB1	3045.5	-3954.5
CTRB2	3045.5	-3954.5
CTRC	-8544.0	-7589.0
CTSA	6799.0	1871.0
CUBN	-8187.0	-602.0
CYB5A	-1290.0	689.0
CYB5B	-8537.0	190.0
CYB5R3	-4888.0	6347.0
CYC1	1643.0	5325.0
CYGB	-4542.0	-2283.0
CYP11A1	5960.0	6230.0
CYP17A1	1473.0	-5484.0
CYP19A1	1566.0	-4450.0
CYP1A1	253.0	3185.0
CYP1A2	-6527.0	3994.0
CYP1B1	8378.0	-3993.0
CYP21A2	2051.0	-8319.0
CYP24A1	-4217.0	-1499.0
CYP26A1	5436.0	1084.0
CYP26B1	-5454.0	4626.0
CYP26C1	7031.0	3578.0
CYP27A1	1107.0	7478.0
CYP27B1	-3436.0	-2124.0
CYP2A13	-8779.0	-8513.0
CYP2A6	-8779.0	-8513.0
CYP2A7	-8779.0	-8513.0
CYP2C18	-7648.5	-4678.5
CYP2D6	-8757.5	3160.5
CYP2E1	-8721.0	-7546.0
CYP2F1	-8216.0	6520.0
CYP2J2	-214.0	-7865.0
CYP2R1	-1071.0	125.0
CYP2S1	-1435.0	-6629.0
CYP2U1	2123.0	5799.0
CYP2W1	-3685.0	-1050.0
CYP39A1	5763.0	-2897.0
CYP3A4	-8713.0	-7493.0
CYP3A43	-8713.0	-7493.0
CYP3A5	-8713.0	-7493.0
CYP3A7	-8713.0	-7493.0
CYP46A1	-7973.0	5165.0
CYP4A11	-7454.5	-8266.5
CYP4A22	-7454.5	-8266.5
CYP4B1	-6380.0	-2611.0
CYP4F11	-7454.5	-8266.5
CYP4F12	-7454.5	-8266.5
CYP4F2	-7833.0	1727.0
CYP4F22	3801.0	-6125.0
CYP4F3	-3823.0	-6815.0
CYP4F8	-8762.0	7837.0
CYP4V2	-2489.0	3792.0
CYP51A1	932.0	-7012.0
CYP7A1	2797.0	7517.0
CYP7B1	4665.0	-7470.0
CYP8B1	1240.0	6726.0
D2HGDH	-5292.0	520.0
DAO	-7904.0	-1143.0
DARS1	3713.0	-1936.0
DBH	2387.0	-1903.0
DBI	8491.0	7771.0
DBT	-6849.0	5517.0
DCK	4255.0	-4511.0
DCN	7508.0	785.0
DCTD	3497.0	7124.0
DCTPP1	-5882.0	4408.0
DCXR	-5794.0	8374.0
DDAH1	-5363.0	-3247.0
DDAH2	-4300.0	-1543.0
DDC	-8724.0	-3206.0
DDHD1	8256.0	4353.0
DDHD2	1145.0	-6010.0
DDO	-2962.0	-5899.0
DECR1	-3353.0	-1646.0
DEGS1	6413.0	2471.0
DEGS2	1935.0	2767.0
DERA	-4241.0	6072.0
DGAT1	4607.0	7925.0
DGAT2	-370.0	8349.0
DGAT2L6	430.0	1634.0
DGUOK	5472.0	8742.0
DHCR24	-7222.0	-3116.0
DHCR7	-8131.0	-3914.0
DHFR	2934.5	-2096.5
DHFR2	2934.5	-2096.5
DHODH	3154.0	-4273.0
DHRS7B	-4658.0	2732.0
DHTKD1	-5757.0	-7525.0
DIO1	-7497.0	-2251.0
DIO2	6321.0	3295.0
DLAT	6055.0	6731.0
DLD	3620.0	2901.0
DLST	2103.0	7989.0
DMAC2L	4240.0	5813.0
DMGDH	1480.0	-1273.0
DNM2	-8541.0	5593.0
DNPH1	6925.0	1646.0
DPEP1	-8073.0	6543.0
DPEP2	-4618.0	-2331.0
DPEP3	6883.0	-752.0
DPYD	8180.0	-8348.0
DPYS	-5903.0	-1059.0
DSE	8275.5	4354.5
DSEL	8043.0	-7361.0
DTYMK	8289.0	-7404.0
DUOX1	488.0	-3431.0
DUOX2	6026.0	-4308.0
DUT	671.0	-7639.0
EBP	3671.5	-5772.5
ECHS1	-2892.0	7032.0
ECI1	574.0	7523.0
ECI2	8370.0	8604.0
ECSIT	-2263.0	8037.0
EEF1E1	5688.5	-6156.5
EEFSEC	-8222.0	-6671.0
EHHADH	-493.0	3887.0
ELOVL1	-8733.0	8830.0
ELOVL2	-1398.0	-5251.0
ELOVL3	-3366.0	4081.0
ELOVL4	-3374.0	-2373.0
ELOVL5	-3367.0	-4695.0
ELOVL6	2616.0	2206.0
ELOVL7	2940.0	-3672.0
ENO1	-5453.0	1267.0
ENO2	1501.0	3839.0
ENO3	100.0	6749.0
ENOPH1	-446.0	-4015.0
ENPP1	-2972.0	1185.0
ENPP2	-6635.0	-8118.0
ENPP3	-1079.0	-2803.0
ENPP6	6840.0	7874.0
ENTPD1	7666.0	-2108.0
ENTPD2	2704.0	1774.0
ENTPD3	3566.0	4382.0
ENTPD4	7707.0	1745.0
ENTPD5	1178.0	7850.0
ENTPD6	7446.0	6440.0
ENTPD7	7003.0	-5555.0
ENTPD8	-1818.0	3167.0
EP300	1364.0	2866.0
EPHX1	-2719.0	283.0
EPHX2	6259.0	-5095.0
EPM2A	3222.0	3950.0
EPRS1	7534.0	7665.0
ERCC2	-5698.0	3292.0
ESD	-2270.0	3024.0
ESRRA	7860.0	8595.0
ESYT1	-3208.0	-2319.0
ESYT2	5465.0	-747.0
ESYT3	-6539.0	-5671.0
ETFA	3199.0	5540.0
ETFB	-2415.0	6029.0
ETFDH	-352.0	7165.0
ETHE1	2511.0	2072.0
ETNK1	4239.0	-3525.0
ETNK2	-8511.0	-7922.0
ETNPPL	-5570.0	-7200.0
EXT1	3396.0	-1348.0
EXT2	-6449.0	-3786.0
FA2H	-5083.0	270.0
FAAH	-7237.0	-3513.0
FABP1	-4774.0	-6119.0
FABP12	7249.0	4257.0
FABP2	-6369.0	-1904.0
FABP3	3748.0	6027.0
FABP4	4090.0	-7024.0
FABP5	3403.0	1738.0
FABP6	-1835.0	5038.0
FABP7	-2908.0	2791.0
FABP9	-4234.0	-591.0
FADS1	-3067.0	-7385.0
FADS2	817.0	-6190.0
FAH	-6168.0	-7352.0
FAHD1	6514.0	7880.0
FAM120B	-5999.0	6456.0
FAR1	-4679.0	-4575.0
FAR2	6249.0	-7198.0
FASN	-7321.0	556.0
FAU	-8349.0	-6727.0
FBP1	-5609.0	2129.0
FBP2	-6519.0	1919.0
FDFT1	-3595.0	5915.0
FDX1	4257.0	339.0
FDX2	4207.5	4238.5
FECH	931.0	7139.0
FH	-2698.0	6352.0
FHL2	1378.0	2124.0
FIG4	3736.0	5851.0
FITM1	-1210.0	1364.0
FITM2	3652.0	1886.0
FLAD1	4101.0	8014.0
FLVCR1	-8669.0	-8105.0
FMO1	5314.0	6815.0
FMO2	-6978.0	6665.0
FMO3	-6694.0	3046.0
FMOD	7485.0	2107.0
FOLH1	7125.0	366.0
FOLR2	1001.0	3958.0
FPGS	-210.0	135.0
FTCD	-7666.0	2363.0
FUT1	5724.0	-27.0
FUT10	-5233.0	-157.0
FUT11	4005.0	868.0
FUT2	-6446.0	736.0
FUT4	4294.0	-5816.0
FUT7	6555.0	-4203.0
FUT9	-7107.0	-5053.0
FXN	-5533.0	8213.0
G0S2	6232.0	1624.0
G6PC	-8740.0	-8096.0
G6PC3	105.0	2276.0
G6PD	-4473.0	1808.0
GAA	-4557.0	6081.0
GALC	-1720.0	3736.0
GALE	7304.0	200.0
GALK1	-7051.0	-7438.0
GALT	-7009.0	5452.0
GAMT	-147.0	8335.0
GAPDH	-5450.0	7449.0
GAPDHS	-4469.0	6757.0
GART	-3582.0	4192.0
GATM	-7936.0	1781.0
GBA	-3563.0	2605.0
GBA2	2847.0	5773.0
GBA3	-4820.0	8587.0
GBE1	-1027.0	7440.0
GC	-7495.0	-7077.0
GCAT	-3151.0	-3577.0
GCDH	-1552.0	6227.0
GCH1	3717.0	890.0
GCHFR	2257.0	1055.0
GCK	8012.0	1604.0
GCKR	-5191.0	-5184.0
GCLC	655.0	-2355.0
GCLM	6644.0	5308.0
GCSH	2536.0	7557.0
GDA	-808.0	-1551.0
GDE1	-2227.0	7144.0
GDPD1	1304.0	-5166.0
GDPD3	5858.0	-1188.0
GDPD5	-5812.0	3919.0
GGCT	-61.5	891.5
GGPS1	1014.0	-8480.0
GGT1	465.0	-7918.0
GGT5	-5593.0	-8377.0
GGT6	-7699.0	3712.0
GGT7	-3005.0	-2268.0
GK	8494.5	-7536.5
GK2	848.0	3028.5
GK3P	8494.5	-7536.5
GLA	3107.0	6804.0
GLB1	-4568.0	5019.0
GLB1L	3082.0	-5614.0
GLCE	5838.0	-6301.0
GLDC	-8029.0	8465.0
GLIPR1	-7390.0	-415.0
GLO1	1342.0	1240.0
GLP1R	8271.0	-6324.0
GLRX	-3816.0	6542.0
GLRX5	6133.0	6661.0
GLS	7790.0	958.0
GLS2	1379.0	-5865.0
GLTP	-2326.0	-2751.0
GLUD1	-2773.5	5970.5
GLUD2	-2773.5	5970.5
GLUL	-6632.0	6503.0
GLYAT	6572.0	-6912.0
GLYCTK	-4136.0	-5017.0
GM2A	-5645.0	-3700.0
GMPR	-6311.0	8339.0
GMPR2	-1022.0	-5759.0
GMPS	4920.0	8243.0
GNA11	-2620.0	601.0
GNA14	-6709.0	6831.0
GNA15	86.0	-5622.0
GNAI1	-7376.0	5037.0
GNAI2	-4164.0	-1806.0
GNAS	-8325.0	6344.0
GNB1	-3640.0	-6683.0
GNB2	5974.0	-7330.0
GNB3	7638.0	7679.0
GNB4	-4332.0	-7844.0
GNB5	-107.0	-6520.0
GNG10	6819.0	-2589.0
GNG11	3479.0	-2086.0
GNG12	-5616.0	-1630.0
GNG13	-1861.0	-5806.0
GNG2	6500.0	-4950.0
GNG3	3036.0	-91.0
GNG4	-7043.0	-588.0
GNG5	826.0	6410.0
GNG7	-2816.0	-6814.0
GNG8	6323.0	6548.0
GNGT2	4096.0	4482.0
GNMT	-6326.0	3836.0
GNPAT	2380.0	1238.0
GNPDA1	3340.0	6660.0
GNPDA2	6606.0	-2619.0
GNS	-308.0	2171.0
GOT1	5192.0	5669.0
GOT2	2003.0	2192.0
GPAM	-6348.0	7995.0
GPAT2	-6432.0	29.0
GPAT3	2523.0	99.0
GPAT4	3757.0	-4684.0
GPC1	3367.0	6196.0
GPC2	-3314.0	5398.0
GPC3	-1882.0	-3616.0
GPC4	-6887.0	1767.0
GPC6	-1169.0	-3182.0
GPCPD1	30.0	4864.0
GPD1	-3181.0	7851.0
GPD1L	-2453.0	6932.0
GPD2	7404.0	-4798.0
GPHN	-4304.0	5647.0
GPI	-3119.0	6982.0
GPIHBP1	-3154.0	-5543.0
GPS2	-5427.0	5390.0
GPT	-4093.0	6680.0
GPT2	-2513.0	2970.0
GPX1	1998.0	-1020.0
GPX2	-1263.0	-2157.0
GPX4	8425.0	8827.0
GRHL1	2308.0	2942.0
GRHPR	-7467.0	-8516.0
GSR	-6513.0	-6817.0
GSS	-1159.0	7680.0
GSTA5	-8452.0	-7287.0
GSTK1	-2940.0	-5138.0
GSTM1	-7750.0	-7321.0
GSTM2	-8768.0	6535.0
GSTM3	-4882.0	-3697.0
GSTM4	3319.0	-6430.0
GSTO1	8161.0	8565.0
GSTO2	-564.0	5324.0
GSTP1	-6885.0	-4820.0
GSTT2	-8361.5	-8279.5
GSTT2B	-8361.5	-8279.5
GSTZ1	-8419.0	-7748.0
GUK1	6528.0	7196.0
GUSB	-7388.0	-725.0
GYG1	4175.0	7887.0
GYS1	2191.0	7346.0
GYS2	-7017.0	-40.0
HAAO	-7040.0	-202.0
HACD1	-941.0	4925.0
HACD2	-4646.0	571.0
HACD3	4606.0	-6425.0
HACD4	-4407.0	599.0
HACL1	626.0	-2726.0
HADH	-1542.0	5840.0
HADHA	-1441.0	5164.0
HADHB	-2312.0	6232.0
HAGH	3972.0	6673.0
HAL	-2729.0	532.0
HAO1	-2762.0	6279.0
HAO2	4933.0	6926.0
HAS1	5659.0	-3268.0
HAS2	-2061.0	-3473.0
HAS3	8109.0	-7148.0
HDAC3	5261.0	761.0
HDC	-7698.0	4815.0
HELZ2	-4461.0	-3126.0
HEXA	4846.5	1383.5
HEXB	7292.0	4368.0
HGD	-7038.0	-2744.0
HIBADH	-1561.0	5463.0
HIBCH	7757.0	8424.0
HILPDA	7080.0	516.0
HK1	-2761.0	8486.0
HK2	2892.0	4306.0
HK3	8601.0	7623.0
HLCS	-6497.0	3853.0
HMBS	7133.0	8087.0
HMGCL	3044.0	3800.0
HMGCLL1	2947.0	3531.0
HMGCR	813.0	-6597.0
HMGCS1	3409.0	-7162.0
HMGCS2	-3139.0	2722.0
HMMR	6182.0	-5904.0
HMOX1	838.0	6054.0
HMOX2	7807.0	8718.0
HOGA1	3130.0	-6357.0
HPD	-7867.0	-2464.0
HPGD	7828.0	-2861.0
HPGDS	2157.0	-4462.0
HPRT1	418.0	-2661.0
HPSE	4097.0	-5948.0
HPSE2	-4172.0	-2002.0
HS2ST1	3019.5	-2833.5
HS3ST1	8464.0	7609.0
HS3ST2	2751.0	2374.0
HS3ST3A1	6873.0	-916.0
HS3ST3B1	3439.0	-5079.0
HS3ST5	-6646.0	5128.0
HS3ST6	-5293.0	7655.0
HS6ST1	-4309.0	8211.0
HS6ST2	-6601.0	-4120.0
HSCB	4363.0	-4640.0
HSD11B2	-6671.0	-5785.0
HSD17B1	7846.0	1299.0
HSD17B10	-171.0	5832.0
HSD17B11	1108.0	-3750.0
HSD17B12	-8473.0	3926.0
HSD17B13	-71.0	-7855.0
HSD17B14	-5264.0	-6327.0
HSD17B2	-241.0	810.5
HSD17B3	-311.0	1687.0
HSD17B4	4640.0	8400.0
HSD17B7	1096.0	-3244.0
HSD17B8	8581.0	8666.0
HSD3B7	1015.0	-4814.0
HSP90AB1	-2904.0	8328.0
HSPG2	-3510.0	-2622.0
HYAL1	4095.0	7768.0
HYAL2	5339.0	8484.0
HYAL3	-2102.0	3298.0
HYKK	2742.0	1035.0
IARS1	6979.0	8593.0
IDH1	645.0	6338.0
IDH2	-6791.0	7310.0
IDH3A	-64.0	7065.0
IDH3B	434.0	6615.0
IDH3G	-2889.0	2505.0
IDI1	2698.0	-6892.0
IDO1	2488.0	1271.0
IDO2	-7148.0	-6897.0
IDS	-6271.5	-5013.5
IDUA	-5488.0	-146.0
IL4I1	-8665.0	5407.0
IMPA1	5734.0	-2125.0
IMPA2	6955.0	7617.0
IMPDH1	6851.0	-5770.0
IMPDH2	-5520.0	2764.0
INMT	8102.5	6920.5
INPP1	7662.0	-1302.0
INPP4A	2135.0	-49.0
INPP4B	-7765.0	8612.0
INPP5A	-2045.0	4866.0
INPP5B	2152.0	-4663.0
INPP5D	-2917.0	-577.0
INPP5E	2839.0	-785.0
INPP5F	3381.0	-4916.0
INPP5J	646.0	7049.0
INPP5K	-1915.0	8689.0
INPPL1	4342.0	8428.0
INS	721.5	-2721.0
INSIG1	8056.0	-8090.0
INSIG2	6325.0	-2410.0
IP6K1	2813.0	-1573.0
IP6K2	-8538.0	722.0
IP6K3	-7758.0	4022.0
IPMK	-3960.0	-332.0
IPPK	1843.0	5081.0
IQGAP1	3630.0	-5536.0
ISCA1	1606.0	3274.0
ISCA2	39.0	5850.0
ISCU	1294.0	6931.0
ISYNA1	-1848.0	1717.0
ITPA	5655.0	658.0
ITPK1	-7386.0	3481.0
ITPKA	-5811.0	6182.0
ITPKB	-2183.0	-3505.0
ITPKC	-6122.0	5541.0
ITPR1	8605.0	-5457.0
ITPR2	-5569.0	-4498.0
ITPR3	-5778.0	-4615.0
IVD	-5897.0	4040.0
IYD	-3275.0	-7931.0
KARS1	521.0	6337.0
KCNB1	-7810.0	2758.0
KCNC2	1459.0	-8271.0
KCNG2	-4846.0	3600.0
KCNJ11	966.0	6243.0
KCNS3	5636.0	-743.0
KDSR	2853.0	5477.0
KERA	6503.0	-2437.0
KHK	-5234.0	-6796.0
KMO	683.0	-8131.0
KPNB1	1085.0	1605.0
KYAT1	2413.5	8018.5
KYAT3	1814.0	6570.0
KYNU	2528.0	-5134.0
L2HGDH	4426.0	4326.0
LARS1	664.0	542.0
LCLAT1	-2696.0	-7325.0
LDHA	-3338.0	1521.0
LDHB	-415.5	7317.5
LDHC	-7316.0	7296.0
LDLR	2690.0	-7724.0
LGMN	-3451.0	4817.0
LHPP	-5691.0	4441.0
LIAS	-5692.0	5873.0
LIPE	-1957.0	216.0
LIPH	-3343.0	7963.0
LIPT1	-4686.0	-5038.0
LIPT2	2680.0	4059.0
LMBRD1	1070.0	-5615.0
LPCAT1	-1591.0	3240.0
LPCAT2	-1184.0	-5171.0
LPCAT3	-2835.0	781.0
LPCAT4	4457.0	4635.0
LPGAT1	-494.0	976.0
LPIN1	2632.0	7747.0
LPIN2	7445.0	-85.0
LPIN3	-3290.0	-4545.0
LPL	-2238.0	3473.0
LRAT	-4187.0	-8008.0
LRP1	4525.0	-3430.0
LRP10	-3049.0	1097.0
LRP12	7377.0	6292.0
LRP2	-5280.0	-5955.0
LRP8	1858.0	2029.0
LSS	-8045.0	-7766.0
LTA4H	6643.0	-1680.0
LTC4S	900.0	109.0
LUM	776.0	-3133.0
LYPLA1	3904.0	-4344.0
LYVE1	4492.0	-1591.0
MAN2B1	-5848.5	-5895.5
MAN2B2	-7594.0	-3571.0
MAN2C1	-5178.0	8545.0
MANBA	-7623.0	-5093.0
MAOA	-5784.0	-526.0
MAOB	-2981.0	-2592.0
MAPKAPK2	2711.0	5425.0
MARCKS	7033.0	-7306.0
MARS1	3978.0	5741.0
MAT1A	-8507.0	-6739.0
MAT2A	6622.0	8122.0
MAT2B	7935.0	7964.0
MBOAT1	-7900.0	-5027.0
MBOAT2	-1729.0	-2503.0
MBOAT7	6605.0	603.0
MBTPS1	-7530.0	-7884.0
MBTPS2	-8485.0	-7477.0
MCAT	-3761.0	6049.0
MCCC1	-1888.0	4867.0
MCCC2	-1157.0	8097.0
MCEE	3371.0	5115.0
MDH1	2610.0	6896.0
MDH2	-3909.0	1091.0
ME1	591.0	-80.0
ME2	2166.0	9.0
ME3	4563.0	7888.0
MECR	3720.0	7287.0
MED1	3661.0	1292.0
MED10	6376.0	-4443.0
MED11	3821.0	6955.0
MED12	-7050.0	-7679.0
MED13	2287.0	1951.0
MED13L	-8526.0	-6559.0
MED14	8621.0	-8551.0
MED15	-6372.0	-5121.0
MED16	-8264.0	8766.0
MED17	1561.5	-3009.5
MED18	-3623.0	-2928.0
MED19	832.0	4465.0
MED20	7440.0	8389.0
MED21	947.0	2617.0
MED22	-6301.0	-359.0
MED23	-5946.0	-1976.0
MED24	-6733.0	4750.0
MED25	-3916.0	2616.0
MED26	-8554.5	7179.5
MED27	-3060.0	5267.0
MED28	7061.0	5594.0
MED29	6341.0	8360.0
MED30	-1930.0	2125.0
MED31	4497.0	7692.0
MED4	5207.0	6859.0
MED6	6246.0	3724.0
MED7	-5279.0	2067.0
MED9	6860.0	8695.0
MFSD2A	-4616.0	-7749.0
MGLL	-7308.0	-7146.0
MGST1	-7913.0	-5306.0
MGST2	2057.0	-7039.0
MGST3	4459.0	4736.0
MID1IP1	-1003.0	7208.0
MIGA1	1848.0	-3446.0
MIGA2	5869.0	6217.0
MINPP1	6682.0	-7759.0
MIOX	131.0	2033.0
MLX	-143.0	4327.0
MLYCD	3424.0	7970.0
MMAA	-3997.0	2983.0
MMAB	-6470.0	7319.0
MMACHC	-3912.0	2940.0
MMADHC	6083.0	-2122.0
MMS19	-2318.0	1357.0
MMUT	3007.0	3582.0
MOCOS	-8759.0	-97.0
MOCS1	-3987.0	7358.0
MOCS2	2137.0	8422.0
MOCS3	497.0	567.0
MOGAT1	-5621.0	-6196.0
MOGAT2	-6512.0	4171.0
MORC2	8488.0	6161.0
MPC1	7100.0	5720.0
MPC2	5072.0	4734.0
MPST	-6424.0	7566.0
MRI1	-5507.0	4692.0
MSMO1	4699.0	-8256.0
MT-ATP6	-2757.0	1204.0
MT-ATP8	-2853.0	-4774.0
MT-CO1	-2993.0	7342.0
MT-CO2	-2478.0	6828.0
MT-CO3	2221.0	1527.0
MT-CYB	-2903.0	1337.0
MT-ND1	-3770.0	2451.0
MT-ND2	-783.0	299.0
MT-ND3	-3514.0	1797.0
MT-ND4	-3963.0	382.0
MT-ND5	-4600.0	1285.0
MT-ND6	-4778.0	-754.0
MTAP	4014.5	-6707.5
MTARC1	4867.5	-5834.5
MTARC2	3999.0	3732.0
MTF1	5860.0	-7180.0
MTHFD1	-4695.0	2077.0
MTHFD1L	-7644.0	4254.0
MTHFD2	29.0	1589.0
MTHFD2L	-4870.0	-3681.0
MTHFR	-7239.0	-1861.0
MTHFS	-2160.5	-4058.5
MTM1	-4048.0	6126.0
MTMR1	-8408.0	5767.0
MTMR10	7799.0	-6772.0
MTMR12	130.0	-6534.0
MTMR14	-1824.0	6421.0
MTMR2	-801.0	6628.0
MTMR3	-7905.0	8298.0
MTMR4	4659.0	6509.0
MTMR6	5587.0	5801.0
MTMR7	6766.0	7935.0
MTMR9	6397.0	-2017.0
MTR	-4850.0	146.0
MTRR	-7042.0	7001.0
MVD	-800.0	6215.0
MVK	4545.0	4294.0
N6AMT1	-4603.0	6206.0
NAALAD2	-1161.0	-8187.0
NADK	3725.0	-4576.0
NADK2	1046.0	414.0
NADSYN1	-6202.0	-7068.0
NAGLU	5928.0	-3779.0
NAGS	-1515.0	-5442.0
NAMPT	6163.0	7473.0
NAPRT	7728.0	6874.0
NAT1	3353.5	-4807.5
NAT2	3353.5	-4807.5
NAT8L	-3783.0	-5871.0
NAXD	2861.0	6463.0
NAXE	-7404.0	-3487.0
NCAN	8025.0	6771.0
NCOA1	-6462.0	-3286.0
NCOA2	-4921.0	152.0
NCOA3	-4410.0	224.0
NCOA6	-5529.0	-2873.0
NCOR1	-7854.0	-1720.0
NCOR2	-8231.0	-238.0
NDC1	5943.0	-442.0
NDOR1	-1135.0	2805.0
NDST1	-1056.0	-4260.0
NDST2	-7207.5	6832.5
NDST3	-5241.0	3393.0
NDST4	-867.5	-2879.0
NDUFA1	7797.0	-3580.0
NDUFA10	-377.0	5987.0
NDUFA11	662.5	4964.5
NDUFA12	1609.0	8560.0
NDUFA13	-81.0	7199.0
NDUFA2	7987.0	5613.0
NDUFA3	2870.0	2229.0
NDUFA4	3762.0	1226.0
NDUFA5	676.0	3420.0
NDUFA6	5924.0	5771.0
NDUFA7	5691.5	3873.5
NDUFA8	5987.0	8490.0
NDUFA9	1104.0	3610.0
NDUFAB1	6473.0	4242.0
NDUFAF1	-2181.0	2883.0
NDUFAF3	-2409.0	6988.0
NDUFAF4	125.0	6668.0
NDUFAF5	-2715.0	1947.0
NDUFAF6	-2930.0	-2683.0
NDUFAF7	7863.0	2760.0
NDUFB10	-1877.0	6302.0
NDUFB11	7357.0	-361.0
NDUFB2	-2642.0	4479.0
NDUFB3	7684.0	-3453.0
NDUFB4	-7278.0	-3860.0
NDUFB5	3542.0	1027.0
NDUFB6	3414.0	3235.0
NDUFB7	-2445.0	2370.0
NDUFB8	2773.5	4506.5
NDUFB9	4566.0	5421.0
NDUFC1	6283.0	3026.0
NDUFC2	781.5	2587.5
NDUFS1	119.0	2981.0
NDUFS2	-1004.0	6854.0
NDUFS3	2309.0	6202.0
NDUFS4	4055.0	2334.0
NDUFS5	-2600.0	8309.0
NDUFS6	7811.0	-2761.0
NDUFS7	-2856.0	7757.0
NDUFS8	2854.0	5403.0
NDUFV1	-133.0	6803.0
NDUFV2	3291.0	6011.0
NDUFV3	8473.0	-6717.0
NEU1	8466.0	8608.0
NEU2	-4961.0	4818.0
NEU3	2720.0	-289.0
NEU4	3345.0	4113.0
NFS1	2149.0	8043.0
NFYA	1966.0	7015.0
NFYB	-8007.0	1927.0
NFYC	-4084.0	7696.0
NHLRC1	2451.0	8176.0
NME1	5788.0	-4888.0
NME2	2164.0	5687.0
NME3	-4181.0	-2962.0
NMNAT1	5002.0	5349.0
NMNAT2	3491.0	-7938.0
NMNAT3	-1083.0	319.0
NMRAL1	7403.0	-7630.0
NMRK1	5712.0	4603.0
NMRK2	-53.0	7962.0
NNMT	7272.0	-7591.0
NNT	-231.0	772.0
NOS3	2187.0	5258.0
NOSIP	-7812.0	7263.0
NOSTRIN	6593.0	-2020.0
NPAS2	-612.0	-7499.0
NQO1	-1479.0	4949.0
NQO2	6236.0	5638.0
NR1D1	3085.0	3519.0
NR1H2	-4706.0	-1579.0
NR1H3	-7111.0	5311.0
NR1H4	4318.0	-7115.0
NRF1	-7057.0	7889.0
NSDHL	3851.0	-7005.0
NT5C	4350.0	3084.0
NT5C1A	-5180.0	-728.0
NT5C1B	-3417.5	-8374.5
NT5C2	2440.0	1406.0
NT5C3A	-6356.0	8118.0
NT5E	88.0	-7648.0
NT5M	2214.0	7216.0
NUBP1	-2426.0	5804.0
NUBP2	977.0	4594.0
NUBPL	4558.0	-1135.0
NUDT1	-1628.0	2678.0
NUDT11	6178.0	4752.0
NUDT12	3157.0	6008.0
NUDT13	-2627.0	6112.0
NUDT15	-6570.0	3933.0
NUDT18	-1138.0	4293.0
NUDT19	5874.0	6437.0
NUDT3	-3927.0	7218.0
NUDT4	-2803.5	-2401.5
NUDT5	8485.0	-7667.0
NUDT7	8148.0	-6709.0
NUDT9	-3047.0	7727.0
NUP107	770.0	-4987.0
NUP133	-3867.0	-5218.0
NUP153	6561.0	3197.0
NUP155	4390.0	-5945.0
NUP160	5614.0	-1355.0
NUP188	2881.0	-1808.0
NUP205	-2971.0	-126.0
NUP210	-4075.0	-1647.0
NUP214	-8456.0	-8322.0
NUP35	2300.0	3137.0
NUP37	8306.0	-8104.0
NUP42	-38.0	3012.0
NUP43	-7853.0	-3161.0
NUP50	3023.0	7983.0
NUP54	2383.0	-72.0
NUP58	8481.0	7137.0
NUP62	-2850.0	4347.0
NUP85	-7742.0	-3075.0
NUP88	2082.0	-764.0
NUP93	5076.0	-4859.0
NUP98	6285.0	-4382.0
OAT	-3675.0	7330.0
OAZ1	-3500.0	2116.0
OAZ2	-7799.0	5052.0
OAZ3	-1166.0	338.0
OCA2	-3137.0	-4011.0
OCRL	4541.0	2627.0
ODC1	8188.0	6746.0
OGDH	-5740.0	4362.0
OGN	8192.0	-5702.0
OLAH	2268.0	512.0
OMD	7152.0	-3558.0
OPLAH	6997.0	8619.0
ORMDL1	-4928.0	-757.0
ORMDL2	6304.0	-2800.0
ORMDL3	-5599.0	8175.0
OSBP	-2271.0	5005.0
OSBPL10	-6234.0	-6451.0
OSBPL1A	7134.0	7659.0
OSBPL2	-4773.0	5220.0
OSBPL3	-2079.0	-730.0
OSBPL5	7612.0	-2.0
OSBPL6	6271.0	-4806.0
OSBPL7	-4957.0	-2041.0
OSBPL8	-7312.0	-5549.0
OSBPL9	-4202.0	-6369.0
OTC	-2319.0	3700.0
OXCT1	2575.0	6362.0
PAH	-8323.0	1094.0
PAICS	8085.0	-478.0
PANK1	5687.0	2857.0
PANK2	5762.0	-3787.0
PANK3	6527.0	-7174.0
PANK4	-2242.0	4884.0
PAOX	-1449.5	7587.5
PAPSS1	4046.0	-6365.0
PAPSS2	5122.0	7787.0
PARP10	-1024.0	5889.0
PARP14	87.0	-2566.0
PARP16	-2403.0	-7682.0
PARP4	-8531.0	8476.0
PARP6	-3043.0	6624.0
PARP8	-5725.0	-1385.0
PARP9	4730.0	-110.0
PC	-8587.0	4574.0
PCBD1	-4876.0	-4096.0
PCCA	1291.0	8102.0
PCCB	-7145.0	2979.0
PCK1	-8530.0	1331.0
PCK2	-1465.0	1324.0
PCTP	-599.0	-4906.0
PCYT1A	-5047.0	4092.0
PCYT1B	605.0	-8039.0
PCYT2	3481.0	7742.0
PDHA1	-1572.0	6522.0
PDHB	4035.0	8121.0
PDHX	6673.0	8447.0
PDK1	-2244.0	4071.0
PDK2	-5697.0	7102.0
PDK3	-21.0	-6639.0
PDK4	-5726.0	-493.0
PDP1	-7819.0	8521.0
PDP2	3218.0	2237.0
PDPR	3181.0	6000.0
PDSS1	6113.0	5603.0
PDSS2	-3273.0	7838.0
PDXK	-6190.0	-1837.0
PDZD11	-8791.0	-8557.0
PECR	7288.0	8280.0
PEMT	-5082.0	1228.0
PEX11A	-7795.0	-6883.0
PFAS	5060.0	5157.0
PFKFB1	7103.0	-6296.0
PFKFB2	-8322.0	8320.0
PFKFB3	8655.0	8815.0
PFKFB4	7970.0	-7040.0
PFKL	6839.0	5610.0
PFKM	1976.0	7331.0
PFKP	-292.0	1148.0
PGAM2	-4526.0	6715.0
PGK1	-1265.0	7828.0
PGLS	5146.0	7648.0
PGM1	-2171.0	7136.0
PGM2	7539.0	-5386.0
PGM2L1	-6145.0	4739.0
PGP	6788.0	7423.0
PGS1	6965.0	1747.0
PHGDH	2025.0	-5687.0
PHKA1	7624.0	8352.0
PHKA2	438.0	-3593.0
PHKB	-2254.0	7128.0
PHKG1	-254.0	-2049.0
PHKG2	4693.0	8492.0
PHOSPHO1	-5617.0	6280.0
PHYH	-1794.0	7155.0
PHYKPL	7551.0	1139.0
PI4K2A	4585.0	2062.0
PI4K2B	2028.0	2088.0
PI4KA	2000.0	-1759.0
PI4KB	4764.0	1127.0
PIAS4	1961.0	7802.0
PIK3C2A	-4032.0	-6026.0
PIK3C2B	-2658.0	-726.0
PIK3C2G	914.0	-7304.0
PIK3C3	5209.0	7133.0
PIK3CA	82.0	-3696.0
PIK3CB	181.5	-4179.0
PIK3CD	-4479.0	-4086.0
PIK3CG	6551.0	-4399.0
PIK3R1	7815.0	4899.0
PIK3R2	-6826.5	1491.5
PIK3R3	470.5	349.5
PIK3R4	3914.0	1845.0
PIK3R5	-5218.0	-5522.0
PIK3R6	-5980.0	-2943.0
PIKFYVE	8023.0	-4495.0
PIP4K2A	-7022.0	-2382.0
PIP4K2B	-4087.0	5983.0
PIP4K2C	3364.0	7470.0
PIP5K1A	5095.0	-3273.0
PIP5K1B	-4596.0	7926.0
PIP5K1C	-5583.0	3993.0
PIPOX	-7344.0	-2969.0
PISD	8294.0	8642.0
PITPNB	-6943.0	7521.0
PITPNM1	-2239.0	-457.0
PITPNM2	-2584.0	-5170.0
PITPNM3	-1681.0	-2018.0
PKLR	-8333.0	4737.0
PKM	1078.0	8675.0
PLA1A	2179.0	2132.0
PLA2G10	1653.0	5415.0
PLA2G12A	1986.0	7013.0
PLA2G15	-3166.0	5192.0
PLA2G1B	1958.0	-2274.0
PLA2G2A	3122.0	-1766.0
PLA2G2D	1999.0	-1128.0
PLA2G2F	-4801.0	-7718.0
PLA2G3	-3093.0	2683.0
PLA2G4A	8255.0	-2638.0
PLA2G4B	4501.5	-3527.5
PLA2G4C	1709.0	4647.0
PLA2G4D	-1485.0	-4772.0
PLA2G4E	-1620.0	2439.0
PLA2G4F	652.0	7224.0
PLA2G5	2801.0	5337.0
PLA2G6	-8745.0	8367.0
PLA2R1	-8246.0	-1180.0
PLAAT1	3009.0	2335.0
PLAAT3	-2619.0	8438.0
PLAAT5	-7152.0	-4676.0
PLB1	-8120.0	7640.0
PLBD1	4417.0	5616.0
PLCB1	-3795.0	4753.0
PLCB2	6897.0	-6276.0
PLCB3	-7682.0	3196.0
PLCB4	-8101.0	8738.0
PLCD1	942.0	7774.0
PLCD3	-17.0	7168.0
PLCD4	-2591.0	3786.0
PLCE1	-5113.0	6594.0
PLCG1	-4979.0	-3013.0
PLCG2	5229.0	-4842.0
PLCH1	8280.0	-8111.0
PLCH2	-5666.0	-4164.0
PLCZ1	358.0	-2480.0
PLD1	5997.0	-8493.0
PLD2	-1692.0	-2365.0
PLD3	-4205.0	4566.0
PLD4	-1928.0	910.0
PLD6	-1562.0	-3099.0
PLEKHA1	-2868.0	-7622.0
PLEKHA2	2978.0	5694.0
PLEKHA3	2974.0	-246.0
PLEKHA4	-4231.0	706.0
PLEKHA5	3308.0	-8083.0
PLEKHA8	-2162.0	-4232.0
PLIN1	-8729.0	-6037.0
PLIN2	-803.0	6441.0
PLIN3	-626.0	7418.0
PLPP1	4915.0	-6057.0
PLPP2	-7189.0	-2772.0
PLPP3	3662.5	1759.5
PLPP6	-379.0	-4566.0
PM20D1	-6192.0	-7588.0
PMVK	-7048.0	-4186.0
PNLIP	1669.0	838.5
PNMT	-2618.0	-378.0
PNP	-6584.0	294.0
PNPLA2	-3928.0	3795.0
PNPLA3	4392.0	5496.0
PNPLA4	6780.0	3929.0
PNPLA6	4004.0	6528.0
PNPLA7	5877.0	369.0
PNPLA8	8559.0	-2314.0
PNPO	4231.0	3878.0
PODXL2	-2992.0	4569.0
POLD1	3733.0	-2448.0
POM121	-3479.5	-928.5
POM121C	-3479.5	-928.5
POMC	2992.0	4075.0
PON1	-7796.0	1811.0
PON2	-5159.0	-6240.0
PON3	1451.0	-2842.0
POR	-5677.0	8144.0
PPA1	6963.0	5621.0
PPA2	7765.0	-5688.0
PPARA	-226.0	6604.0
PPARD	-6659.0	2423.0
PPARG	-8223.0	-3183.0
PPARGC1A	2820.0	1081.0
PPARGC1B	-8304.0	7543.0
PPAT	888.0	-1328.0
PPCDC	4674.0	7597.0
PPCS	3934.0	-1291.0
PPIP5K1	8267.0	8853.0
PPIP5K2	8647.0	8726.0
PPM1K	5286.0	4920.0
PPM1L	-1487.0	932.0
PPOX	-6653.0	5732.0
PPP1CA	-5613.0	8001.0
PPP1CB	1677.0	-1715.0
PPP1CC	8630.0	2152.0
PPP1R3C	-1579.0	2036.0
PPP2CA	-5989.0	-1036.0
PPP2CB	-3379.0	-1146.0
PPP2R1A	-3227.0	6730.0
PPP2R1B	4232.0	3139.0
PPP2R5D	469.0	5899.0
PPT1	4835.0	-2649.0
PPT2	-8701.5	8841.5
PRELP	8573.0	306.0
PRKAA2	4171.0	6123.0
PRKAB2	-128.0	8793.0
PRKACA	-7439.0	7145.0
PRKACB	-6436.0	1450.0
PRKAG2	-1682.0	-732.0
PRKAR1A	-4709.0	5819.0
PRKAR1B	7738.0	1273.0
PRKAR2A	-7831.0	8145.0
PRKAR2B	-8604.0	-8020.0
PRKCA	-1604.0	-4833.0
PRKD1	-7399.0	-4188.0
PRKD2	-2333.0	-440.0
PRKD3	-8040.0	-7998.0
PRKG2	7303.0	1974.0
PRODH	4769.5	1930.5
PRODH2	-8215.0	-7673.0
PRPS1	7369.0	5114.0
PRPS1L1	-867.5	-4022.0
PRPS2	-5620.0	469.0
PRSS1	-169.0	-3195.0
PRSS3	-169.0	-3195.0
PRXL2B	5672.0	-117.0
PSAP	-6404.0	5173.0
PSAT1	8265.0	-2121.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
PSPH	-7941.0	-6319.0
PSTK	6670.0	-569.0
PTDSS1	-6991.0	-2536.0
PTDSS2	3918.0	-4037.0
PTEN	-2571.0	6959.0
PTGDS	-1839.5	4613.5
PTGES	-3530.0	2813.0
PTGES2	5947.0	7917.0
PTGES3	4089.0	-7298.0
PTGIS	8603.0	-5073.0
PTGR1	4729.0	5821.0
PTGR2	-1081.5	7984.5
PTGS1	4581.0	1828.0
PTGS2	7925.0	-613.0
PTPMT1	6745.0	-4731.0
PTPN13	7466.0	1045.0
PTS	2832.0	-3871.0
PXMP2	-8184.0	6792.0
PYCR1	5035.0	4338.0
PYCR2	2127.5	-3937.5
PYGB	-6771.0	6304.0
PYGL	-7198.0	-6423.0
PYGM	-3499.0	6633.0
QDPR	-5388.0	-3272.0
QPRT	-4133.0	-6483.0
RAB14	-1225.0	1120.0
RAB4A	4583.0	7363.0
RAB5A	-1080.0	2003.0
RAE1	-4200.0	-5786.0
RAN	-867.5	-670.5
RANBP2	6652.0	1313.0
RAP1A	772.0	-2570.0
RAPGEF3	-6233.0	5703.0
RAPGEF4	4393.0	3322.0
RARS1	-367.0	1437.0
RBKS	-2634.0	1328.0
RBP1	-6704.0	-3493.0
RBP2	-867.5	317.0
RBP4	-7903.0	-1898.0
RDH11	8310.5	6795.5
RETSAT	-542.0	6311.0
RFK	-2192.0	-2556.0
RGL1	1024.0	-1718.0
RHCE	-7379.5	-2291.5
RHD	-7379.5	-2291.5
RIDA	-3478.0	-3712.0
RIMKLA	4283.0	7493.0
RIMKLB	829.0	-2100.0
RNLS	-5024.0	4577.0
RORA	981.0	-3060.0
RPE	7372.5	-7017.5
RPEL1	7372.5	-7017.5
RPIA	-5501.0	5571.0
RPL10A	540.0	4827.0
RPL10L	6226.0	-4646.0
RPL13	-6936.0	5766.0
RPL13A	8662.0	8769.0
RPL15	-5860.0	4087.0
RPL18	2526.0	4846.0
RPL18A	-1925.0	4548.0
RPL19	4213.0	6491.0
RPL21	181.5	45.0
RPL22	5649.0	1761.0
RPL23	-1809.0	3014.0
RPL23A	-6572.0	-7943.0
RPL24	-3019.0	1992.0
RPL27	2645.0	-5667.0
RPL28	-3044.0	6689.0
RPL29	8624.0	6370.0
RPL3	8648.0	-7240.0
RPL30	7077.0	-6538.0
RPL31	5384.0	-1644.0
RPL35	-2959.0	5845.0
RPL35A	-8622.0	-4858.0
RPL36	1102.0	-1619.0
RPL37	7745.0	359.0
RPL37A	1829.0	295.0
RPL38	-5365.0	-4825.0
RPL3L	-6787.0	5079.0
RPL5	3976.0	-4117.0
RPL6	8594.0	-7663.0
RPL7	2882.0	-3180.0
RPL7A	6807.0	-2288.0
RPL8	-3908.0	2263.0
RPL9	4597.0	4414.0
RPLP1	-600.0	-6598.0
RPLP2	6247.0	8473.0
RPS10	-1770.5	6339.5
RPS11	2070.0	6190.0
RPS13	3415.0	-8357.0
RPS14	5495.0	5365.0
RPS15	5952.0	535.0
RPS15A	8625.0	-4215.0
RPS16	8612.0	-7367.0
RPS17	-1744.0	-7106.0
RPS18	6266.0	-6297.0
RPS19	1867.0	-6360.0
RPS2	-1499.0	-3494.0
RPS21	3740.0	-6563.0
RPS23	6740.0	-2710.0
RPS25	-221.0	-4349.0
RPS26	4910.0	3317.0
RPS27A	7076.0	2193.0
RPS27L	-2849.0	1056.0
RPS28	2906.0	-86.0
RPS3	2452.0	-3227.0
RPS3A	4511.0	126.0
RPS4X	2298.0	4334.0
RPS5	5938.0	1963.0
RPS6	-5452.0	3079.0
RPS7	-1931.0	5162.0
RPS8	3111.0	1095.0
RPS9	-7262.0	7861.0
RPSA	-1325.0	5495.0
RRM1	6199.0	-8015.0
RRM2	-7678.0	-7228.0
RRM2B	4460.0	6768.0
RTEL1	-4259.5	-8211.5
RUFY1	-3889.0	7639.0
RXRA	-4958.0	387.0
RXRB	-7681.0	8892.0
SACM1L	5841.0	-606.0
SAMD8	1978.0	3193.0
SAMHD1	8382.0	8323.0
SAR1B	871.0	6219.0
SARDH	-6019.0	2166.0
SARS1	-5348.0	1659.0
SAT1	7936.0	-5283.0
SBF1	3074.0	947.0
SBF2	-8127.0	-7807.0
SC5D	3380.0	971.0
SCAP	-3948.0	8390.0
SCD	-2745.0	-4177.0
SCLY	6619.0	4312.0
SCO1	-1140.0	6877.0
SDC1	7023.0	-7120.0
SDC2	6159.0	-6681.0
SDC3	-1826.0	1368.0
SDC4	-2743.0	-3481.0
SDHA	-1653.5	4126.5
SDHB	1308.0	6790.0
SDHC	1049.0	4498.0
SDHD	-257.5	2208.5
SDS	-8290.0	-8204.0
SDSL	3945.0	-5873.0
SEC13	880.0	-1374.0
SEC23A	-1026.0	-37.0
SEC24A	-6042.0	-8065.0
SEC24B	-4899.0	-3709.0
SEC24D	5545.0	6983.0
SECISBP2	-5708.0	-6541.0
SELENOI	8480.0	8315.0
SEPSECS	1079.0	2984.0
SERINC1	3005.0	4116.0
SERINC2	-5499.0	-78.0
SERINC3	95.0	-245.0
SERINC4	8282.0	8665.0
SERINC5	-2240.0	-6632.0
SERPINA6	-1803.0	3471.0
SGMS1	1198.0	8846.0
SGMS2	1549.0	-358.0
SGPL1	-8057.0	3737.0
SGPP1	3882.0	2018.0
SGPP2	6550.0	-76.0
SGSH	-3469.0	171.0
SHMT1	-6732.0	5367.0
SHMT2	-2330.0	5750.0
SHPK	-1667.5	3621.5
SIN3A	-8282.0	-5944.0
SIN3B	-3699.0	7007.0
SLC10A1	-184.0	-6394.0
SLC16A1	1474.0	-367.0
SLC16A3	2487.0	-369.0
SLC16A8	1819.0	-5156.0
SLC19A1	-8015.0	8483.0
SLC19A2	8645.0	6433.0
SLC19A3	4396.0	1830.0
SLC22A1	-8545.0	-29.0
SLC22A13	-5493.0	1848.0
SLC22A2	3628.0	-8299.0
SLC22A3	3127.0	-5646.0
SLC23A1	1051.0	-6256.0
SLC23A2	4204.0	-2610.0
SLC25A1	3527.0	-3690.0
SLC25A10	971.5	5909.5
SLC25A11	-2393.0	6953.0
SLC25A12	-6950.0	7548.0
SLC25A13	4690.0	7555.0
SLC25A14	6828.0	-4482.0
SLC25A15	2655.0	4038.0
SLC25A17	-1247.0	3124.0
SLC25A19	-3995.0	6555.0
SLC25A2	6086.0	-3868.0
SLC25A20	268.0	8174.0
SLC25A21	-7006.0	-3415.0
SLC25A27	6049.0	3632.0
SLC25A28	3417.0	5341.0
SLC25A32	-1642.5	2503.5
SLC25A37	6420.0	4771.0
SLC25A44	5516.0	8741.0
SLC26A1	-4440.0	-4445.0
SLC26A2	-3663.0	-2626.0
SLC27A1	-2127.0	7438.0
SLC27A2	-8616.0	-1781.0
SLC27A3	-4.0	-6201.0
SLC27A5	-245.0	2424.0
SLC2A1	-4746.0	3840.0
SLC2A2	3048.0	3602.0
SLC35B2	5318.0	6540.0
SLC35B3	-7443.0	1673.0
SLC35D1	-2638.0	672.0
SLC35D2	-809.5	-6471.5
SLC36A4	6989.0	-6612.0
SLC37A1	-5868.0	2323.0
SLC37A2	8459.0	8881.0
SLC37A4	790.0	6956.0
SLC3A2	-4114.0	-1351.0
SLC44A1	-3088.0	-7356.0
SLC44A2	-2093.0	-5.0
SLC44A3	1708.0	776.0
SLC44A4	-3037.0	6198.0
SLC44A5	-5108.0	-8326.0
SLC45A2	4672.0	4406.0
SLC46A1	-1541.0	-3365.0
SLC52A1	-3201.5	-815.5
SLC52A2	-3201.5	-815.5
SLC52A3	7842.0	-7072.0
SLC5A5	2708.0	8009.0
SLC5A6	7888.0	197.0
SLC5A8	-617.0	-3738.0
SLC6A11	-2911.0	-14.0
SLC6A12	-7060.0	-7978.0
SLC6A7	-7450.0	-1.0
SLC6A8	700.5	-934.5
SLC7A5	-3004.0	-3076.0
SLC9A1	-2099.0	-2867.0
SLCO1A2	-7885.0	-8128.0
SLCO1B1	-3759.0	-6203.0
SLCO1B3	-3759.0	-6203.0
SLCO2B1	-5463.0	-520.0
SMARCD3	-1042.0	7471.0
SMOX	-5260.0	-1428.0
SMPD1	5329.0	6718.0
SMPD2	5470.0	4711.0
SMPD3	8019.0	2926.0
SMPD4	-1084.0	4573.0
SMS	-3396.0	-1117.0
SNAP25	-8652.0	-1631.0
SORD	2240.0	-1290.0
SP1	-1270.0	-6646.0
SPHK1	5895.0	-8231.0
SPHK2	-3687.0	4310.0
SPNS2	-3701.0	723.0
SPR	8154.0	8519.0
SPTLC1	5279.0	-4960.0
SPTLC2	-8445.0	-1316.0
SPTLC3	7982.0	4632.0
SPTSSA	-5574.0	-6136.0
SQLE	6493.0	-7425.0
SRD5A1	-6725.0	-558.0
SRD5A2	-5273.0	4018.0
SRD5A3	-8063.0	5781.0
SREBF1	-4331.0	-6100.0
SREBF2	-5936.0	-5493.0
SRM	-756.0	7112.0
SRR	-3924.0	-7449.0
ST3GAL1	6987.0	7996.0
ST3GAL2	4333.0	-2700.0
ST3GAL3	-5728.0	5532.0
ST3GAL4	7059.0	1405.0
ST3GAL6	2913.0	2671.0
ST6GALNAC6	5424.5	6818.5
STAB2	-5649.0	5788.0
STAR	-2140.0	-4082.0
STARD10	-8488.0	8192.0
STARD3	-4647.0	-5620.0
STARD3NL	2407.0	-7116.0
STARD4	-1563.0	-6168.0
STARD5	6530.0	3968.0
STARD6	-8237.0	-7985.0
STARD7	-3847.0	2101.0
STK11	3779.0	7387.0
STS	-6850.0	7710.0
STX1A	-421.0	-7172.0
STXBP1	-1457.0	6951.0
SUCLA2	-2280.0	3175.0
SUCLG1	4086.0	3231.0
SUCLG2	-4818.0	-229.0
SULT1A1	616.0	4160.0
SULT1A2	616.0	4160.0
SULT1A3	-2105.5	8200.5
SULT1A4	-2105.5	8200.5
SULT1B1	3975.0	-5498.0
SULT1C2	-8631.0	-8370.0
SULT1E1	-8208.5	-766.5
SULT2A1	-8773.0	-8498.0
SULT2B1	8314.0	2670.0
SULT4A1	4349.0	1485.0
SULT6B1	1013.0	-5821.0
SUMF1	-4471.0	2597.0
SUMO2	-3443.0	-5439.0
SUOX	-3395.0	4144.0
SURF1	818.0	5283.0
SYNJ1	7253.0	-4580.0
SYNJ2	6175.0	8513.0
SYT5	-3350.0	-6669.0
TACO1	1469.0	7286.0
TALDO1	2099.0	5894.0
TAT	-969.0	-6015.0
TAZ	3849.0	5446.0
TBL1X	1374.5	-7236.5
TBL1XR1	-4920.0	-5301.0
TBXAS1	5422.0	-3550.0
TCN2	-3612.0	-1430.0
TDO2	3369.0	-1303.0
TECR	-3203.0	3599.0
TECRL	705.0	1940.0
TGS1	4510.0	-1069.0
TH	-1823.0	-581.0
THEM4	6362.0	1815.0
THEM5	1091.0	3204.0
THRAP3	-5220.0	-1634.0
THRSP	-7933.0	-1295.0
THTPA	2518.0	-7643.0
TIAM2	4557.0	-3250.0
TIMMDC1	4421.0	7069.0
TK1	-5970.0	-5010.0
TK2	518.0	-6725.0
TKFC	4410.0	1933.0
TKT	3668.0	-1760.0
TM7SF2	6849.0	-6878.0
TMEM126B	2822.0	-2468.0
TMEM86B	-7985.0	2726.0
TMLHE	8524.0	-7557.0
TNFAIP8	1673.0	7020.0
TNFAIP8L1	-67.0	-4172.0
TNFAIP8L2	4249.0	-5357.0
TNFAIP8L3	-6156.0	-5503.0
TNFRSF21	4000.0	-2499.0
TPH1	3493.0	3286.0
TPH2	1640.5	-2273.0
TPI1	-6879.0	-8521.0
TPK1	5246.0	-1331.0
TPMT	7911.0	8763.0
TPO	1141.0	-2914.0
TPR	-186.0	2533.0
TPST1	8492.0	-8519.0
TPST2	2244.0	-2162.0
TPTE	-3302.5	5727.5
TPTE2	-3302.5	5727.5
TRAP1	-3817.0	7194.0
TRIB3	-2317.0	-7114.0
TRMT112	-4378.0	-4723.0
TSHB	-5052.0	2159.0
TSPO	3587.0	6392.0
TSPOAP1	2327.0	-5040.0
TST	-3580.0	-3442.0
TSTD1	2100.0	242.0
TTPA	-7838.0	-2076.0
TTR	-8563.0	-2206.0
TXN	4635.0	-1043.0
TXN2	-1147.0	-7182.0
TXNRD1	6015.0	7455.0
TYMP	-69.0	5792.0
TYMS	7375.0	-3351.0
TYR	-1335.0	-1794.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
UBE2I	3358.0	-871.0
UBIAD1	2307.0	-83.0
UCK1	-5134.0	4256.0
UCK2	-5783.0	-1584.0
UCKL1	-76.0	7763.0
UCP1	2158.0	-356.0
UCP2	-6256.0	3987.0
UCP3	-1127.0	-4919.0
UGCG	-3579.0	-3924.0
UGDH	5888.0	-7388.0
UGP2	5772.0	5471.0
UGT1A1	-8784.0	-8559.0
UGT2A3	-8356.0	8558.0
UGT8	-4425.0	3789.0
UMPS	-2325.0	3847.0
UPB1	-5866.0	-5589.0
UPP1	604.0	5187.0
UPP2	-1934.0	1522.0
UQCR10	5657.0	3744.0
UQCR11	-3327.5	2636.5
UQCRB	7471.0	-7671.0
UQCRC1	-746.0	6208.0
UQCRC2	686.0	3409.0
UQCRFS1	-512.0	6119.0
UQCRH	2930.5	4859.5
UQCRQ	3103.0	4519.0
UROC1	-2898.0	-21.0
UROD	-5477.0	-2777.0
UROS	5986.0	7084.0
UST	4711.0	-4173.0
VAC14	3644.0	-2461.0
VAMP2	-6761.5	-121.5
VAPA	6672.0	-6441.0
VAPB	-4769.0	7012.0
VCAN	7513.0	-7936.0
VDAC1	-3136.0	4155.0
VDR	-669.0	6870.0
VKORC1	7188.0	-6206.0
VKORC1L1	5322.0	-6195.0
VNN1	6290.0	-598.0
WASL	-5204.0	-2654.0
XDH	4549.0	3398.0
XYLB	-3100.0	-3815.0
XYLT1	-7518.0	719.0
XYLT2	-7084.0	-162.0
ZDHHC21	3447.0	-6356.0

---

---

Defective CFTR causes cystic fibrosis

Defective CFTR causes cystic fibrosis

metric	value
setSize	58
pMANOVA	1.48e-08
p.adjustMANOVA	1.53e-06
s.dist	0.454
s.skel	0.0599
s.heart	0.45
p.skel	0.43
p.heart	3.09e-09

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
RNF5	6460.0	8372.0
DERL3	6952.0	7048.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
SEL1L	6297.0	4440.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
ERLIN1	5512.0	3816.0
PSMA7	5019.0	3863.0
DERL2	5929.0	3169.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0

Click HERE to show all gene set members

All member genes

	skel	heart
CFTR	1846.0	333.0
DERL1	-6364.0	3464.0
DERL2	5929.0	3169.0
DERL3	6952.0	7048.0
ERLEC1	96.0	2284.0
ERLIN1	5512.0	3816.0
ERLIN2	-6349.0	2941.0
OS9	-5143.0	4690.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RNF185	-6526.0	6567.0
RNF5	6460.0	8372.0
RPS27A	7076.0	2193.0
SEL1L	6297.0	4440.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
VCP	-3107.0	6482.0

---

---

tRNA Aminoacylation

tRNA Aminoacylation

metric	value
setSize	41
pMANOVA	1.99e-08
p.adjustMANOVA	1.9e-06
s.dist	0.532
s.skel	0.211
s.heart	0.488
p.skel	0.0194
p.heart	6.44e-08

Top 20 genes

Gene	skel	heart
NARS1	7904	8630
NARS2	7594	8507
MARS2	7803	7855
IARS1	6979	8593
EPRS1	7534	7665
HARS2	7265	7381
WARS1	6568	7737
EARS2	6218	6675
PPA1	6963	5621
GARS1	7347	4390
TARS1	7437	3698
HARS1	6567	3942
MARS1	3978	5741
AIMP2	2900	7129
LARS2	2455	8388
CARS1	4522	4053
AIMP1	5901	2626
PARS2	7234	2108
RARS2	2776	4302
FARS2	814	8586

Click HERE to show all gene set members

All member genes

	skel	heart
AARS1	-4806.0	7803.0
AARS2	-6223.0	5546.0
AIMP1	5901.0	2626.0
AIMP2	2900.0	7129.0
CARS1	4522.0	4053.0
CARS2	-8348.0	1141.0
DARS1	3713.0	-1936.0
DARS2	-4570.0	6989.0
EARS2	6218.0	6675.0
EEF1E1	5688.5	-6156.5
EPRS1	7534.0	7665.0
FARS2	814.0	8586.0
FARSA	1666.0	3030.0
FARSB	-1329.0	1464.0
GARS1	7347.0	4390.0
HARS1	6567.0	3942.0
HARS2	7265.0	7381.0
IARS1	6979.0	8593.0
IARS2	-2969.0	8731.0
KARS1	521.0	6337.0
LARS1	664.0	542.0
LARS2	2455.0	8388.0
MARS1	3978.0	5741.0
MARS2	7803.0	7855.0
NARS1	7904.0	8630.0
NARS2	7594.0	8507.0
PARS2	7234.0	2108.0
PPA1	6963.0	5621.0
PPA2	7765.0	-5688.0
RARS1	-367.0	1437.0
RARS2	2776.0	4302.0
SARS1	-5348.0	1659.0
SARS2	-5658.5	3876.5
TARS1	7437.0	3698.0
TARS2	-5883.0	5290.0
VARS1	-4791.0	8791.0
VARS2	-7094.0	8753.0
WARS1	6568.0	7737.0
WARS2	-6764.0	-3139.0
YARS1	917.0	4152.0
YARS2	-936.0	-1237.0

---

---

Extracellular matrix organization

Extracellular matrix organization

metric	value
setSize	271
pMANOVA	2.11e-08
p.adjustMANOVA	1.9e-06
s.dist	0.213
s.skel	0.125
s.heart	-0.172
p.skel	0.000398
p.heart	1.09e-06

Top 20 genes

Gene	skel	heart
COL1A2	8646	-8142
LOX	8629	-7835
ASPN	7938	-8423
COL17A1	8431	-7864
NRXN1	8193	-8035
IBSP	7590	-8043
LOXL2	8048	-7502
VCAN	7513	-7936
CAST	7653	-7574
COL9A1	7629	-7596
CD47	7645	-7542
ADAMTS2	7792	-7360
CASK	6208	-8550
P4HA3	8121	-6524
DMD	7170	-7384
COL5A1	6940	-7391
SDC1	7023	-7120
MMP3	7257	-6705
MFAP5	7124	-6721
CD44	5992	-7861

Click HERE to show all gene set members

All member genes

	skel	heart
A2M	-3629.0	-4704.0
ACAN	6744.0	4680.0
ACTN1	929.0	-7282.0
ADAM10	-5138.0	2105.0
ADAM12	878.0	-5949.0
ADAM15	-6665.0	4804.0
ADAM17	-1887.0	-476.0
ADAM19	4708.0	-3959.0
ADAM8	-2267.0	-5319.0
ADAM9	6093.0	3282.0
ADAMTS1	2907.0	1813.0
ADAMTS14	4506.0	-8449.0
ADAMTS16	3213.0	460.0
ADAMTS18	1372.0	-5440.0
ADAMTS2	7792.0	-7360.0
ADAMTS3	7115.0	-3699.0
ADAMTS4	-4813.0	-6757.0
ADAMTS5	3419.0	-6165.0
ADAMTS8	5964.0	-438.0
ADAMTS9	3483.0	96.0
AGRN	-978.0	-4541.0
ASPN	7938.0	-8423.0
BCAN	-7508.0	4213.0
BGN	5498.0	-2960.0
BMP1	6942.0	-3393.0
BMP10	33.0	-777.0
BMP2	6019.0	2449.0
BMP4	3908.0	-5892.0
BMP7	2478.0	3514.0
BSG	6138.0	8069.0
CAPN1	978.0	-6682.0
CAPN10	-3907.0	-6191.0
CAPN11	687.0	-196.0
CAPN12	-4216.0	-7441.0
CAPN13	4.0	-5006.0
CAPN15	-1652.0	-568.0
CAPN2	-3041.0	1855.0
CAPN3	-8160.0	-8190.0
CAPN5	-2920.0	-7877.0
CAPN6	4673.0	-4596.0
CAPN7	115.0	-3303.0
CAPN8	6061.0	-6155.0
CAPN9	742.0	2542.0
CAPNS1	-7347.0	8169.0
CASK	6208.0	-8550.0
CASP3	-4102.0	-890.0
CAST	7653.0	-7574.0
CD151	1511.0	8770.0
CD44	5992.0	-7861.0
CD47	7645.0	-7542.0
CDH1	-4250.0	-3780.0
CEACAM1	-4145.5	-8052.5
CEACAM6	-4145.5	-8052.5
CEACAM8	-4145.5	-8052.5
CMA1	6124.0	-3362.0
COL11A1	6464.0	-4136.0
COL11A2	8290.0	7577.0
COL12A1	7185.0	-178.0
COL13A1	8138.0	-1750.0
COL14A1	4918.0	-4721.0
COL15A1	-5886.0	-7959.0
COL16A1	8070.0	-4660.0
COL17A1	8431.0	-7864.0
COL18A1	-4869.0	-4416.0
COL19A1	340.0	4545.0
COL1A1	7658.0	-5194.0
COL1A2	8646.0	-8142.0
COL23A1	2919.0	241.0
COL25A1	-8018.0	-8002.0
COL26A1	3501.0	8279.0
COL27A1	786.0	4537.0
COL28A1	-2751.0	1895.0
COL2A1	6821.0	3122.0
COL3A1	3633.0	-5649.0
COL4A1	-4211.0	-906.0
COL4A2	-4558.0	3087.0
COL4A3	277.0	-2252.0
COL4A5	-2815.0	-3410.0
COL4A6	3357.0	3153.0
COL5A1	6940.0	-7391.0
COL5A2	2796.0	-2318.0
COL5A3	-795.0	-6519.0
COL6A1	3476.0	-5787.0
COL6A2	4476.0	-4395.0
COL6A5	-5511.0	-7144.0
COL6A6	-3515.0	-6225.0
COL8A1	6875.0	-5009.0
COL8A2	7772.0	1154.0
COL9A1	7629.0	-7596.0
COL9A2	-7469.0	-4035.0
COLGALT1	-822.0	4399.0
COLGALT2	-7519.0	-2425.0
COMP	8611.0	3205.0
CRTAP	2651.0	-6133.0
CTRB1	3045.5	-3954.5
CTRB2	3045.5	-3954.5
CTSB	-1172.0	2279.0
CTSD	2408.5	5828.5
CTSK	6566.0	-2899.0
CTSS	2144.0	1663.0
CTSV	-4285.0	-863.0
DAG1	-7689.0	2735.0
DCN	7508.0	785.0
DDR1	8597.0	8849.0
DDR2	5845.0	-4021.0
DMD	7170.0	-7384.0
DMP1	-1047.0	5875.0
DSPP	448.0	1640.5
DST	5620.0	4619.0
EFEMP1	-2436.0	-1283.0
EFEMP2	8435.0	-4600.0
ELANE	-611.0	-3283.0
ELN	1389.0	-5399.0
F11R	-3656.0	-512.0
FBLN1	-1524.0	-5346.0
FBLN2	624.0	108.0
FBLN5	6771.0	1308.0
FBN1	5549.0	-5406.0
FBN2	4722.0	-6499.0
FGA	-8420.0	-6269.0
FGB	-8775.0	-8311.0
FGF2	2551.0	-50.0
FGG	-7760.0	-6173.0
FMOD	7485.0	2107.0
FN1	6620.0	-6064.0
FURIN	-6129.0	-521.0
GDF5	8136.0	3369.0
HAPLN1	5315.0	-3911.0
HSPG2	-3510.0	-2622.0
HTRA1	7850.0	-5071.0
IBSP	7590.0	-8043.0
ICAM1	2786.0	7016.0
ICAM2	-2500.0	129.0
ICAM4	4114.0	3506.0
ICAM5	3526.0	-6111.0
ITGA1	-2823.0	-1776.0
ITGA10	2076.0	-3799.0
ITGA11	5802.0	1214.0
ITGA2	7756.0	2814.0
ITGA2B	-6949.0	7225.0
ITGA3	-6581.0	8039.0
ITGA4	-4036.0	-1867.0
ITGA5	-7482.0	4873.0
ITGA6	-5627.0	-2840.0
ITGA7	3833.0	8673.0
ITGA8	-2054.0	2483.0
ITGA9	7278.0	5209.0
ITGAE	-5049.0	7903.0
ITGAL	-1557.0	5284.0
ITGAM	-8742.0	-7311.0
ITGAV	1994.0	5984.0
ITGAX	-4974.0	-4134.0
ITGB1	2215.0	5645.0
ITGB2	-404.0	138.0
ITGB3	-3130.5	-3851.5
ITGB4	-6582.0	-3433.0
ITGB6	-3977.0	731.0
ITGB7	-7589.0	4183.0
ITGB8	-1316.0	-8369.0
JAM2	-1732.0	4605.0
JAM3	-2893.0	1355.0
KDR	-5465.0	-6405.0
KLK2	1233.5	335.5
KLKB1	-5780.0	1916.0
LAMA1	4444.0	-6710.0
LAMA2	8076.0	7939.0
LAMA3	-5909.0	-7742.0
LAMA4	-1942.0	-6418.0
LAMA5	-4943.0	-355.0
LAMB1	136.0	-5392.0
LAMB2	-7435.0	7273.0
LAMB3	6131.0	4835.0
LAMC1	-3226.0	-7305.0
LAMC2	8618.0	8786.0
LAMC3	-4905.0	1361.0
LOX	8629.0	-7835.0
LOXL1	6792.0	-4822.0
LOXL2	8048.0	-7502.0
LOXL3	-1831.0	-3276.0
LOXL4	5722.0	-4592.0
LRP4	-736.0	2677.0
LTBP1	6223.0	-1278.0
LTBP2	5859.0	-175.0
LTBP3	509.0	-2197.0
LTBP4	-2684.0	-7289.0
LUM	776.0	-3133.0
MADCAM1	1983.0	255.0
MATN1	-867.5	3880.0
MATN3	4048.0	1207.0
MATN4	7200.0	-4430.0
MFAP2	4724.0	-4438.0
MFAP3	-4827.0	-6749.0
MFAP4	4600.0	6164.0
MFAP5	7124.0	-6721.0
MMP11	-6939.0	1942.0
MMP12	-275.0	4077.0
MMP13	-688.0	-4864.0
MMP14	2707.0	-7334.0
MMP15	-6077.0	4351.0
MMP16	6895.0	3949.0
MMP17	638.0	4163.0
MMP19	-1442.0	-4471.0
MMP2	7246.0	-1051.0
MMP20	3641.0	-24.0
MMP24	-4704.0	1778.0
MMP3	7257.0	-6705.0
MMP7	2472.0	-4770.0
MMP8	-7558.0	5342.0
MMP9	7224.0	4324.0
MUSK	-5543.0	-3238.0
NCAM1	-8659.0	988.0
NCAN	8025.0	6771.0
NCSTN	-7938.0	6961.0
NID1	498.0	-5603.0
NID2	-7998.0	-7285.0
NRXN1	8193.0	-8035.0
NTN4	4305.0	4413.0
OPTC	7087.0	-3311.0
P3H1	1808.0	-6415.0
P3H2	5638.0	2201.0
P3H3	3608.0	-2258.0
P4HA1	5255.0	6345.0
P4HA2	8021.0	8225.0
P4HA3	8121.0	-6524.0
P4HB	-2194.0	6155.0
PCOLCE	8040.0	-5842.0
PCOLCE2	6624.0	-4319.0
PDGFA	-7028.0	7764.0
PDGFB	-4620.0	-989.0
PHYKPL	7551.0	1139.0
PLEC	-8801.0	8684.0
PLG	-8727.0	-6409.0
PLOD1	511.0	5968.0
PLOD2	-7684.0	6714.0
PLOD3	4327.0	2195.0
PPIB	6594.0	-1443.0
PRKCA	-1604.0	-4833.0
PRSS1	-169.0	-3195.0
PRSS2	-169.0	-3195.0
PSEN1	-3298.0	574.0
PTPRS	2465.0	6212.0
PXDN	-7402.0	-5076.0
SCUBE1	-1767.0	-3407.0
SCUBE3	-3873.0	-5332.0
SDC1	7023.0	-7120.0
SDC2	6159.0	-6681.0
SDC3	-1826.0	1368.0
SDC4	-2743.0	-3481.0
SERPINE1	-3078.0	2267.0
SERPINH1	7945.0	4411.0
SH3PXD2A	-8708.0	-5915.0
SPARC	5826.0	1892.0
SPOCK3	-4745.0	-544.0
SPP1	-7378.0	6546.0
TGFB1	-1002.0	-1450.0
TGFB2	8533.0	3203.0
TGFB3	670.0	-210.0
THBS1	8333.0	-2377.0
TIMP1	-1091.0	-2604.0
TIMP2	6388.0	-2544.0
TLL1	3804.0	-6022.0
TLL2	5955.0	3793.0
TMPRSS6	-6668.0	4718.0
TNC	7222.0	-5800.0
TNN	5641.0	-3711.0
TNR	-7032.0	-7473.0
TRAPPC4	7829.0	5998.0
TTR	-8563.0	-2206.0
VCAM1	8503.0	6836.0
VCAN	7513.0	-7936.0
VTN	-8593.5	-7429.5

---

---

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

metric	value
setSize	116
pMANOVA	2.81e-08
p.adjustMANOVA	2.33e-06
s.dist	0.314
s.skel	0.124
s.heart	0.288
p.skel	0.0216
p.heart	8.25e-08

Top 20 genes

Gene	skel	heart
ACAD9	7631.0	7946.0
NDUFA8	5987.0	8490.0
NDUFA2	7987.0	5613.0
COX11	5457.0	7979.0
NDUFA6	5924.0	5771.0
TIMMDC1	4421.0	7069.0
NDUFAB1	6473.0	4242.0
COX18	5469.0	4656.0
NDUFB9	4566.0	5421.0
DMAC2L	4240.0	5813.0
NDUFA7	5691.5	3873.5
SLC25A27	6049.0	3632.0
NDUFAF7	7863.0	2760.0
UQCR10	5657.0	3744.0
NDUFV2	3291.0	6011.0
NDUFC1	6283.0	3026.0
ETFA	3199.0	5540.0
NDUFS8	2854.0	5403.0
NDUFS3	2309.0	6202.0
UQCRH	2930.5	4859.5

Click HERE to show all gene set members

All member genes

	skel	heart
ACAD9	7631.0	7946.0
ATP5F1A	-1377.0	-5931.0
ATP5F1B	-1494.0	4951.0
ATP5F1D	-704.0	8523.0
ATP5F1E	5050.0	-1368.0
ATP5MC3	3773.0	312.0
ATP5ME	-4161.0	-3064.0
ATP5MF	2482.0	2566.0
ATP5MG	1185.5	-2613.5
ATP5PB	-6172.0	8413.0
ATP5PD	-68.0	3308.0
ATP5PF	-1793.0	-399.0
ATP5PO	2969.5	2847.5
COQ10A	-6941.0	-2064.0
COQ10B	-149.0	2833.0
COX11	5457.0	7979.0
COX14	2222.0	3423.0
COX16	-1973.0	-7786.0
COX18	5469.0	4656.0
COX19	-2652.0	-1153.0
COX20	2493.0	669.0
COX4I1	2872.0	3827.0
COX5A	3962.0	473.0
COX5B	-1445.0	5794.0
COX6A1	844.0	1034.0
COX6B1	2433.0	-5248.0
COX7A2L	-4533.0	6293.0
COX7B	4671.0	2669.0
COX7C	4843.0	-2111.0
COX8A	2020.0	-4946.0
CYC1	1643.0	5325.0
DMAC2L	4240.0	5813.0
ECSIT	-2263.0	8037.0
ETFA	3199.0	5540.0
ETFB	-2415.0	6029.0
ETFDH	-352.0	7165.0
MT-ATP6	-2757.0	1204.0
MT-ATP8	-2853.0	-4774.0
MT-CO1	-2993.0	7342.0
MT-CO2	-2478.0	6828.0
MT-CO3	2221.0	1527.0
MT-CYB	-2903.0	1337.0
MT-ND1	-3770.0	2451.0
MT-ND2	-783.0	299.0
MT-ND3	-3514.0	1797.0
MT-ND4	-3963.0	382.0
MT-ND5	-4600.0	1285.0
MT-ND6	-4778.0	-754.0
NDUFA1	7797.0	-3580.0
NDUFA10	-377.0	5987.0
NDUFA11	662.5	4964.5
NDUFA12	1609.0	8560.0
NDUFA13	-81.0	7199.0
NDUFA2	7987.0	5613.0
NDUFA3	2870.0	2229.0
NDUFA4	3762.0	1226.0
NDUFA5	676.0	3420.0
NDUFA6	5924.0	5771.0
NDUFA7	5691.5	3873.5
NDUFA8	5987.0	8490.0
NDUFA9	1104.0	3610.0
NDUFAB1	6473.0	4242.0
NDUFAF1	-2181.0	2883.0
NDUFAF3	-2409.0	6988.0
NDUFAF4	125.0	6668.0
NDUFAF5	-2715.0	1947.0
NDUFAF6	-2930.0	-2683.0
NDUFAF7	7863.0	2760.0
NDUFB10	-1877.0	6302.0
NDUFB11	7357.0	-361.0
NDUFB2	-2642.0	4479.0
NDUFB3	7684.0	-3453.0
NDUFB4	-7278.0	-3860.0
NDUFB5	3542.0	1027.0
NDUFB6	3414.0	3235.0
NDUFB7	-2445.0	2370.0
NDUFB8	2773.5	4506.5
NDUFB9	4566.0	5421.0
NDUFC1	6283.0	3026.0
NDUFC2	781.5	2587.5
NDUFS1	119.0	2981.0
NDUFS2	-1004.0	6854.0
NDUFS3	2309.0	6202.0
NDUFS4	4055.0	2334.0
NDUFS5	-2600.0	8309.0
NDUFS6	7811.0	-2761.0
NDUFS7	-2856.0	7757.0
NDUFS8	2854.0	5403.0
NDUFV1	-133.0	6803.0
NDUFV2	3291.0	6011.0
NDUFV3	8473.0	-6717.0
NUBPL	4558.0	-1135.0
PM20D1	-6192.0	-7588.0
SCO1	-1140.0	6877.0
SDHA	-1653.5	4126.5
SDHB	1308.0	6790.0
SDHC	1049.0	4498.0
SDHD	-257.5	2208.5
SLC25A14	6828.0	-4482.0
SLC25A27	6049.0	3632.0
SURF1	818.0	5283.0
TACO1	1469.0	7286.0
TIMMDC1	4421.0	7069.0
TMEM126B	2822.0	-2468.0
TRAP1	-3817.0	7194.0
UCP1	2158.0	-356.0
UCP2	-6256.0	3987.0
UCP3	-1127.0	-4919.0
UQCR10	5657.0	3744.0
UQCR11	-3327.5	2636.5
UQCRB	7471.0	-7671.0
UQCRC1	-746.0	6208.0
UQCRC2	686.0	3409.0
UQCRFS1	-512.0	6119.0
UQCRH	2930.5	4859.5
UQCRQ	3103.0	4519.0

---

---

ABC transporter disorders

ABC transporter disorders

metric	value
setSize	74
pMANOVA	2.91e-08
p.adjustMANOVA	2.33e-06
s.dist	0.395
s.skel	0.0324
s.heart	0.394
p.skel	0.63
p.heart	4.77e-09

Top 20 genes

Gene	skel	heart
ABCB6	8563.0	8795.0
ABCB4	8253.0	8852.0
PSMB8	7349.0	8633.0
RNF5	6460.0	8372.0
ABCC8	7973.0	6381.0
DERL3	6952.0	7048.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
SEL1L	6297.0	4440.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
ERLIN1	5512.0	3816.0
PSMA7	5019.0	3863.0
DERL2	5929.0	3169.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0

Click HERE to show all gene set members

All member genes

	skel	heart
ABCA1	-5829.0	-5026.0
ABCA12	6681.0	2122.0
ABCA3	-3896.0	2176.0
ABCB11	-7464.0	-1458.0
ABCB4	8253.0	8852.0
ABCB6	8563.0	8795.0
ABCC2	-7018.0	4203.0
ABCC6	-6377.0	-7166.0
ABCC8	7973.0	6381.0
ABCC9	-6061.0	-3884.0
ABCD1	-4268.0	6911.0
ABCD4	-5217.0	1069.0
ABCG5	-2216.0	1675.0
ABCG8	5934.0	-5580.0
APOA1	-488.0	3512.0
CFTR	1846.0	333.0
DERL1	-6364.0	3464.0
DERL2	5929.0	3169.0
DERL3	6952.0	7048.0
ERLEC1	96.0	2284.0
ERLIN1	5512.0	3816.0
ERLIN2	-6349.0	2941.0
KCNJ11	966.0	6243.0
OS9	-5143.0	4690.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RNF185	-6526.0	6567.0
RNF5	6460.0	8372.0
RPS27A	7076.0	2193.0
SEL1L	6297.0	4440.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
VCP	-3107.0	6482.0

---

---

Selective autophagy

Selective autophagy

metric	value
setSize	56
pMANOVA	4.62e-08
p.adjustMANOVA	3.46e-06
s.dist	0.452
s.skel	-0.113
s.heart	0.438
p.skel	0.144
p.heart	1.47e-08

Top 20 genes

Gene	skel	heart
CSNK2B	-8515.0	8824.0
PARK7	-8340.0	8811.0
IFT88	-7980.0	8627.0
MAP1LC3B	-8153.5	8186.5
PINK1	-7552.0	8397.0
NBR1	-7939.0	7413.0
MFN2	-6960.0	8451.0
USP30	-7166.0	7213.0
SQSTM1	-5057.0	8580.0
ATG5	-7194.0	5130.0
PRKAB1	-6055.0	5660.0
HDAC6	-6881.0	4275.0
DYNC1I2	-5706.0	5083.0
EPAS1	-6815.0	3574.0
VCP	-3107.0	6482.0
DYNLL2	-3336.0	6037.0
PCNT	-6585.0	2600.0
UBA52	-1940.0	7240.0
VDAC1	-3136.0	4155.0
PRKAG3	-3862.0	2949.0

Click HERE to show all gene set members

All member genes

	skel	heart
ARL13B	7232.0	8489.0
ATG12	2688.0	5077.0
ATG5	-7194.0	5130.0
ATM	8167.0	-4787.0
CETN1	1909.0	-2349.0
CFTR	1846.0	333.0
CSNK2A1	1817.5	4970.5
CSNK2A2	-5978.0	-4520.0
CSNK2B	-8515.0	8824.0
DYNC1H1	7671.0	6805.0
DYNC1I1	5105.0	2652.0
DYNC1I2	-5706.0	5083.0
DYNC1LI1	6461.0	7025.0
DYNC1LI2	4553.0	-2293.0
DYNLL1	1967.0	754.0
DYNLL2	-3336.0	6037.0
EPAS1	-6815.0	3574.0
FUNDC1	5940.0	1799.0
HDAC6	-6881.0	4275.0
HSF1	-3651.0	1899.0
HSPA8	382.0	7793.0
IFT88	-7980.0	8627.0
MAP1LC3A	4067.0	5098.0
MAP1LC3B	-8153.5	8186.5
MFN1	6282.0	7683.0
MFN2	-6960.0	8451.0
MTERF3	-5797.0	-1900.0
NBR1	-7939.0	7413.0
PARK7	-8340.0	8811.0
PCNT	-6585.0	2600.0
PEX5	4433.0	-256.0
PGAM5	2963.0	139.0
PINK1	-7552.0	8397.0
PLIN2	-803.0	6441.0
PLIN3	-626.0	7418.0
PRKAA2	4171.0	6123.0
PRKAB1	-6055.0	5660.0
PRKAB2	-128.0	8793.0
PRKAG2	-1682.0	-732.0
PRKAG3	-3862.0	2949.0
RPS27A	7076.0	2193.0
SQSTM1	-5057.0	8580.0
SRC	-7820.0	-2286.0
TOMM20	15.0	3071.0
TOMM22	3929.0	2851.0
TOMM40	1301.0	8216.0
TOMM6	1744.0	6131.0
TOMM7	1025.0	-4848.0
TOMM70	2750.0	2724.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
UBE2N	3842.5	3787.5
ULK1	-3344.0	450.0
USP30	-7166.0	7213.0
VCP	-3107.0	6482.0
VDAC1	-3136.0	4155.0

---

---

ABC-family proteins mediated transport

ABC-family proteins mediated transport

metric	value
setSize	97
pMANOVA	4.8e-08
p.adjustMANOVA	3.46e-06
s.dist	0.339
s.skel	0.0722
s.heart	0.331
p.skel	0.219
p.heart	1.74e-08

Top 20 genes

Gene	skel	heart
ABCB6	8563.0	8795.0
ABCB4	8253.0	8852.0
PSMB8	7349.0	8633.0
RNF5	6460.0	8372.0
DERL3	6952.0	7048.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
ABCC4	5729.0	7260.0
ABCG4	6462.0	6403.0
ABCF1	4361.0	8882.0
ABCD3	6228.0	6142.0
ABCA7	8246.0	4572.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
SEL1L	6297.0	4440.0
ABCA4	7012.0	3963.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0

Click HERE to show all gene set members

All member genes

	skel	heart
ABCA12	6681.0	2122.0
ABCA2	-4457.0	-463.0
ABCA3	-3896.0	2176.0
ABCA4	7012.0	3963.0
ABCA5	-4156.0	-4556.0
ABCA6	393.0	-4195.0
ABCA7	8246.0	4572.0
ABCA8	8087.0	-6695.0
ABCA9	7366.0	-2534.0
ABCB10	4831.0	1730.0
ABCB4	8253.0	8852.0
ABCB5	-661.5	-6132.0
ABCB6	8563.0	8795.0
ABCB7	6072.0	3682.0
ABCB8	1248.0	8477.0
ABCB9	5217.0	903.0
ABCC1	-5071.0	97.0
ABCC10	-3291.0	4600.0
ABCC2	-7018.0	4203.0
ABCC3	-8425.0	-8337.0
ABCC4	5729.0	7260.0
ABCC5	-6627.0	-8230.0
ABCC6	-6377.0	-7166.0
ABCC9	-6061.0	-3884.0
ABCD1	-4268.0	6911.0
ABCD2	-525.0	4969.0
ABCD3	6228.0	6142.0
ABCF1	4361.0	8882.0
ABCG1	-8590.0	2606.0
ABCG4	6462.0	6403.0
ABCG5	-2216.0	1675.0
ABCG8	5934.0	-5580.0
APOA1	-488.0	3512.0
CFTR	1846.0	333.0
DERL1	-6364.0	3464.0
DERL2	5929.0	3169.0
DERL3	6952.0	7048.0
EIF2S1	4892.0	-4087.0
EIF2S2	3572.0	4652.0
EIF2S3	134.5	2917.5
ERLEC1	96.0	2284.0
ERLIN1	5512.0	3816.0
ERLIN2	-6349.0	2941.0
KCNJ11	966.0	6243.0
OS9	-5143.0	4690.0
PEX19	-2410.0	8332.0
PEX3	-7767.0	-4560.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RNF185	-6526.0	6567.0
RNF5	6460.0	8372.0
RPS27A	7076.0	2193.0
SEL1L	6297.0	4440.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
VCP	-3107.0	6482.0

---

---

Hh mutants that don't undergo autocatalytic processing are degraded by ERAD

Hh mutants that don't undergo autocatalytic processing are degraded by ERAD

metric	value
setSize	53
pMANOVA	1.66e-07
p.adjustMANOVA	1.14e-05
s.dist	0.442
s.skel	0.0554
s.heart	0.438
p.skel	0.485
p.heart	3.36e-08

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
SEL1L	6297.0	4440.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
DERL2	5929.0	3169.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0
PSMA1	2067.0	1803.0

Click HERE to show all gene set members

All member genes

	skel	heart
DERL2	5929.0	3169.0
ERLEC1	96.0	2284.0
OS9	-5143.0	4690.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RPS27A	7076.0	2193.0
SEL1L	6297.0	4440.0
SHH	2945.0	-670.5
SYVN1	-5712.0	7586.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
VCP	-3107.0	6482.0

---

---

Fatty acids

Fatty acids

metric	value
setSize	14
pMANOVA	1.93e-07
p.adjustMANOVA	1.27e-05
s.dist	0.846
s.skel	-0.709
s.heart	-0.463
p.skel	4.38e-06
p.heart	0.00271

Top 20 genes

Gene	skel	heart
CYP2A13	-8779.0	-8513.0
CYP2A7	-8779.0	-8513.0
CYP4A11	-7454.5	-8266.5
CYP4A22	-7454.5	-8266.5
CYP4F11	-7454.5	-8266.5
CYP4F12	-7454.5	-8266.5
CYP4F3	-3823.0	-6815.0
CYP4B1	-6380.0	-2611.0
CYP2J2	-214.0	-7865.0

Click HERE to show all gene set members

All member genes

	skel	heart
CYP2A13	-8779.0	-8513.0
CYP2A7	-8779.0	-8513.0
CYP2D6	-8757.5	3160.5
CYP2F1	-8216.0	6520.0
CYP2J2	-214.0	-7865.0
CYP4A11	-7454.5	-8266.5
CYP4A22	-7454.5	-8266.5
CYP4B1	-6380.0	-2611.0
CYP4F11	-7454.5	-8266.5
CYP4F12	-7454.5	-8266.5
CYP4F2	-7833.0	1727.0
CYP4F22	3801.0	-6125.0
CYP4F3	-3823.0	-6815.0
CYP4F8	-8762.0	7837.0

---

---

Hh mutants abrogate ligand secretion

Hh mutants abrogate ligand secretion

metric	value
setSize	56
pMANOVA	2.12e-07
p.adjustMANOVA	1.33e-05
s.dist	0.427
s.skel	0.0454
s.heart	0.424
p.skel	0.557
p.heart	3.96e-08

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
SEL1L	6297.0	4440.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
DERL2	5929.0	3169.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
HHAT	1647.0	4561.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0

Click HERE to show all gene set members

All member genes

	skel	heart
DERL2	5929.0	3169.0
DHH	1912.0	-1752.0
ERLEC1	96.0	2284.0
HHAT	1647.0	4561.0
IHH	-7214.0	2220.0
OS9	-5143.0	4690.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RPS27A	7076.0	2193.0
SEL1L	6297.0	4440.0
SHH	2945.0	-670.5
SYVN1	-5712.0	7586.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
VCP	-3107.0	6482.0

---

---

Mitochondrial protein import

Mitochondrial protein import

metric	value
setSize	62
pMANOVA	2.59e-07
p.adjustMANOVA	1.56e-05
s.dist	0.401
s.skel	0.13
s.heart	0.379
p.skel	0.0775
p.heart	2.43e-07

Top 20 genes

Gene	skel	heart
CMC2	7233.0	8457.0
CHCHD5	6978.0	7415.0
CHCHD4	8044.0	5901.0
TIMM8B	7528.0	5682.0
TIMM10B	8059.5	4982.5
MTX1	5807.0	6464.0
TIMM44	5188.0	7023.0
SLC25A13	4690.0	7555.0
TIMM10	6441.0	5201.0
SLC25A4	6364.0	5152.0
TIMM50	3581.0	8796.0
GRPEL1	3735.0	7537.0
TIMM22	6328.0	3738.0
TAZ	3849.0	5446.0
SAMM50	3305.0	6012.0
TIMM8A	3221.0	6068.0
COA4	5973.0	2971.0
NDUFB8	2773.5	4506.5
TIMM21	1987.0	5940.0
TOMM22	3929.0	2851.0

Click HERE to show all gene set members

All member genes

	skel	heart
ACO2	769.0	8700.0
ATP5F1A	-1377.0	-5931.0
ATP5F1B	-1494.0	4951.0
BCS1L	986.0	3616.0
CHCHD10	-7909.0	-7733.0
CHCHD2	-7452.0	-7800.0
CHCHD3	1874.0	4935.0
CHCHD4	8044.0	5901.0
CHCHD5	6978.0	7415.0
CHCHD7	107.0	1365.0
CMC2	7233.0	8457.0
CMC4	-5763.0	968.0
COA4	5973.0	2971.0
COA6	-371.0	1175.0
COQ2	-1090.0	5249.0
COX17	3223.0	636.0
COX19	-2652.0	-1153.0
CS	1762.0	5778.0
CYC1	1643.0	5325.0
DNAJC19	4885.0	-268.0
FXN	-5533.0	8213.0
GFER	-2919.0	-4518.0
GRPEL1	3735.0	7537.0
GRPEL2	-4212.0	-4168.0
HSCB	4363.0	-4640.0
HSPA9	520.0	4996.0
HSPD1	-4013.0	5490.0
IDH3G	-2889.0	2505.0
LDHD	-733.0	8640.0
MTX1	5807.0	6464.0
MTX2	6517.0	933.0
NDUFB8	2773.5	4506.5
OTC	-2319.0	3700.0
PAM16	5166.0	1858.0
PITRM1	-4455.0	8346.0
PMPCA	609.0	8054.0
PMPCB	-4835.0	6077.0
SAMM50	3305.0	6012.0
SLC25A12	-6950.0	7548.0
SLC25A13	4690.0	7555.0
SLC25A4	6364.0	5152.0
TAZ	3849.0	5446.0
TIMM10	6441.0	5201.0
TIMM10B	8059.5	4982.5
TIMM13	4041.0	27.0
TIMM17A	601.0	3894.0
TIMM17B	-8629.0	-6611.0
TIMM21	1987.0	5940.0
TIMM22	6328.0	3738.0
TIMM23	-2361.0	6121.0
TIMM44	5188.0	7023.0
TIMM50	3581.0	8796.0
TIMM8A	3221.0	6068.0
TIMM8B	7528.0	5682.0
TIMM9	-2087.0	1293.0
TOMM20	15.0	3071.0
TOMM22	3929.0	2851.0
TOMM40	1301.0	8216.0
TOMM6	1744.0	6131.0
TOMM7	1025.0	-4848.0
TOMM70	2750.0	2724.0
VDAC1	-3136.0	4155.0

---

---

Interleukin-1 signaling

Interleukin-1 signaling

metric	value
setSize	94
pMANOVA	3.54e-07
p.adjustMANOVA	2.04e-05
s.dist	0.325
s.skel	0.0052
s.heart	0.325
p.skel	0.931
p.heart	5.17e-08

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
APP	7187.0	7687.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
NKIRAS1	4837.0	7236.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
IL1B	3746.0	6531.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
IKBKG	2865.0	5671.0
RPS27A	7076.0	2193.0
UBE2N	3842.5	3787.5
PSME4	2756.0	5110.0
IRAK2	4643.0	2844.0
IL1RAP	2258.0	5334.0

Click HERE to show all gene set members

All member genes

	skel	heart
AGER	-8777.0	8839.0
APP	7187.0	7687.0
BTRC	5925.0	-1783.0
CHUK	6014.0	-2315.0
CUL1	-2470.0	5696.0
FBXW11	-7722.0	-1164.0
HMGB1	3450.0	-2498.0
IKBKB	3761.0	1108.0
IKBKG	2865.0	5671.0
IL1A	-5462.0	-7271.0
IL1B	3746.0	6531.0
IL1R1	-8096.0	-6934.0
IL1R2	5989.0	1041.0
IL1RAP	2258.0	5334.0
IL1RN	1463.0	660.0
IRAK1	660.0	400.0
IRAK2	4643.0	2844.0
IRAK3	83.0	-5545.0
IRAK4	-5745.0	-6244.0
MAP2K1	-4947.0	5163.0
MAP2K4	4302.0	-1337.0
MAP2K6	-1023.0	3781.0
MAP3K3	3408.0	2457.0
MAP3K7	2561.0	-3604.0
MAP3K8	-2030.0	6213.0
MYD88	-3161.0	1296.0
NFKB1	-2346.0	2317.0
NFKB2	-1871.0	5814.0
NFKBIB	-2048.0	8312.0
NKIRAS1	4837.0	7236.0
NKIRAS2	-2754.0	7826.0
NOD1	-182.0	7988.0
NOD2	-8346.0	-3204.0
PELI1	4988.0	-6089.0
PELI2	1556.0	-4183.0
PELI3	-4236.0	6583.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RBX1	92.0	4055.0
RELA	-1883.0	-6107.0
RIPK2	-3840.0	-1651.0
RPS27A	7076.0	2193.0
SKP1	944.0	7264.0
SQSTM1	-5057.0	8580.0
TAB1	-5854.0	3142.0
TAB2	-1317.0	6676.0
TAB3	1454.0	5326.0
TNIP2	-2878.0	7130.0
TOLLIP	-4874.0	1269.0
TRAF6	-1959.0	-329.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
UBE2N	3842.5	3787.5

---

---

NIK-->noncanonical NF-kB signaling

NIK-->noncanonical NF-kB signaling

metric	value
setSize	56
pMANOVA	3.85e-07
p.adjustMANOVA	2.14e-05
s.dist	0.417
s.skel	0.0821
s.heart	0.409
p.skel	0.288
p.heart	1.18e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
RELB	7854.0	1239.0
PSMD2	2064.0	4576.0
UBA3	5442.0	1674.0
PSMB1	1753.0	5095.0
UBE2M	951.0	7259.0
SKP1	944.0	7264.0
PSMC6	4466.0	1448.0

Click HERE to show all gene set members

All member genes

	skel	heart
BTRC	5925.0	-1783.0
CHUK	6014.0	-2315.0
CUL1	-2470.0	5696.0
FBXW11	-7722.0	-1164.0
MAP3K14	496.0	1946.0
NFKB2	-1871.0	5814.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RELB	7854.0	1239.0
RPS27A	7076.0	2193.0
SKP1	944.0	7264.0
UBA3	5442.0	1674.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
UBE2M	951.0	7259.0

---

---

Regulation of ornithine decarboxylase (ODC)

Regulation of ornithine decarboxylase (ODC)

metric	value
setSize	49
pMANOVA	4.88e-07
p.adjustMANOVA	2.52e-05
s.dist	0.443
s.skel	0.0644
s.heart	0.438
p.skel	0.435
p.heart	1.1e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
ODC1	8188.0	6746.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
AZIN1	8220.0	2419.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0
PSMA1	2067.0	1803.0
PSMD14	546.0	6040.0

Click HERE to show all gene set members

All member genes

	skel	heart
AZIN1	8220.0	2419.0
NQO1	-1479.0	4949.0
OAZ1	-3500.0	2116.0
OAZ2	-7799.0	5052.0
OAZ3	-1166.0	338.0
ODC1	8188.0	6746.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0

---

---

GPCR downstream signalling

GPCR downstream signalling

metric	value
setSize	706
pMANOVA	4.9e-07
p.adjustMANOVA	2.52e-05
s.dist	0.118
s.skel	-0.0731
s.heart	-0.0924
p.skel	0.000985
p.heart	3.08e-05

Top 20 genes

Gene	skel	heart
KNG1	-8772	-8546
EDNRA	-8720	-8520
SAG	-8731	-8503
GABBR1	-8785	-8232
RRH	-8492	-8454
CCL28	-8498	-8354
PRKAR2B	-8604	-8020
PAK1	-8756	-7874
APOC3	-8626	-7683
TRH	-8042	-8132
GALR2	-7934	-8182
PDE1C	-7328	-8536
DGKE	-8471	-7292
ABR	-7381	-8288
VIP	-7808	-7758
ARHGEF1	-8442	-6904
RGS8	-6769	-8429
PLEKHG2	-6933	-8004
QRFPR	-7702	-6995
RGS17	-8496	-6323

Click HERE to show all gene set members

All member genes

	skel	heart
ABCA4	7012.0	3963.0
ABHD12	-7223.0	7187.0
ABHD6	8035.0	3611.0
ABR	-7381.0	-8288.0
ACKR3	6004.0	-1276.0
ADCY1	-3786.0	223.0
ADCY2	-6164.0	-5813.0
ADCY3	1385.0	-6913.0
ADCY4	-6488.0	1986.0
ADCY5	-2115.0	3615.0
ADCY6	-6611.0	275.0
ADCY7	1963.0	-3579.0
ADCY8	6532.0	4755.0
ADCY9	-1608.0	173.0
ADCYAP1	449.0	-7339.0
ADCYAP1R1	6896.0	-8453.0
ADM	1398.0	7703.0
ADM2	-1861.0	1862.0
ADORA1	-8395.0	8761.0
ADORA2A	-2406.0	6044.0
ADORA2B	-7264.0	4410.0
ADORA3	7825.0	8057.0
ADRA1A	6281.0	3558.0
ADRA1B	3667.0	6004.0
ADRA1D	-4122.0	4066.0
ADRA2A	4300.0	3775.0
ADRA2B	-7216.0	-2923.0
ADRA2C	4641.0	4450.0
ADRB1	3339.0	1172.0
ADRB2	2580.0	-3113.0
ADRB3	-7712.5	6766.5
AGRN	-978.0	-4541.0
AGT	-7588.0	-5820.0
AGTR1	-5316.0	-6949.0
AGTR2	7198.0	4973.0
AHCYL1	7434.0	-3277.0
AKAP13	-4927.0	378.0
AKR1B10	-8633.0	8691.0
AKT1	1272.0	5976.0
AKT2	-5690.0	1098.0
AKT3	8315.0	728.0
ANXA1	6844.0	-3114.0
APLN	-2309.0	-1586.0
APLNR	-4521.0	766.0
APOA1	-488.0	3512.0
APOA2	-7127.0	-5091.0
APOA4	-6487.0	-3735.0
APOB	446.0	-8252.0
APOC2	-7258.5	203.5
APOC3	-8626.0	-7683.0
APOE	-8560.0	-6177.0
APOM	1430.0	-8376.0
APP	7187.0	7687.0
ARHGEF1	-8442.0	-6904.0
ARHGEF10	-703.0	-2723.0
ARHGEF10L	-6353.0	8511.0
ARHGEF11	-8012.0	6720.0
ARHGEF12	5814.0	3188.0
ARHGEF15	-412.0	-1943.0
ARHGEF16	-7393.0	-6440.0
ARHGEF17	-6614.0	-6444.0
ARHGEF18	-2314.5	-1319.5
ARHGEF19	-5281.0	-2648.0
ARHGEF2	7686.0	-8540.0
ARHGEF25	5676.5	5393.5
ARHGEF26	8008.0	-5941.0
ARHGEF3	7338.0	898.0
ARHGEF33	-393.0	5184.0
ARHGEF37	-8558.0	5629.0
ARHGEF38	-4301.0	-1690.0
ARHGEF39	-1107.0	-5839.0
ARHGEF40	-7425.0	-3732.0
ARHGEF5	-7020.0	389.0
ARHGEF6	-5048.0	-2677.0
ARHGEF7	-8259.0	2371.0
ARRB1	-23.0	757.0
ARRB2	-6483.0	-1323.0
AVP	3002.0	2838.0
AVPR1A	50.0	-7417.0
AVPR1B	5291.0	4509.0
AVPR2	-6697.0	-7226.0
AWAT2	7752.0	-7273.0
BCO1	3610.0	-225.0
BCO2	5768.0	-7653.0
BDKRB1	3289.0	-3489.0
BDKRB2	-3799.0	-7975.0
BRS3	-403.0	-4671.0
BTK	7270.0	-7309.0
C3	-6034.0	-8192.0
C3AR1	-3619.0	-5812.0
C5	-8782.0	5917.0
C5AR1	-1115.0	4385.0
CALCA	4552.0	-7312.0
CALCR	-670.0	5387.0
CALCRL	7677.0	-7290.0
CALM1	-82.0	3278.0
CAMK2A	-3643.0	7280.0
CAMK2B	-8620.0	8181.0
CAMK2G	7184.0	5782.0
CAMK4	983.0	6639.0
CAMKK1	4428.0	-3016.0
CAMKK2	-179.0	-5551.0
CAMKMT	2648.0	-7900.0
CASR	-1126.0	-5630.0
CCK	3991.0	-5191.0
CCKAR	-1861.0	405.0
CCKBR	-1539.0	4606.0
CCL19	-6442.0	-1589.0
CCL21	6892.0	-3239.0
CCL23	2923.0	-7957.0
CCL27	4572.0	-6127.0
CCL28	-8498.0	-8354.0
CCL4	-3531.5	-6954.5
CCR1	2814.0	-8123.0
CCR10	-577.0	4352.0
CCR3	-3135.0	3186.0
CCR4	-1861.0	45.0
CCR5	7329.0	-7615.0
CCR6	-4192.0	-5018.0
CCR7	-1074.0	2865.0
CCR8	3847.0	-4718.0
CCR9	-6729.0	-4099.0
CDC42	-8165.0	-2736.0
CDK5	-2367.0	-1608.0
CGA	-260.5	810.5
CHRM1	-3424.0	1980.0
CHRM2	-827.0	2930.0
CHRM3	-8036.0	-4250.0
CHRM4	-6017.0	-6888.0
CHRM5	-6910.0	3353.0
CNGA1	181.5	4321.0
CNGB1	8049.0	-8484.0
CNR1	-6972.0	-7037.0
CNR2	-6500.0	4820.0
CREB1	8140.0	3609.0
CRH	6039.0	7140.0
CRHR1	1517.0	2315.0
CRHR2	-8755.0	7004.0
CX3CL1	-2019.0	-1910.0
CX3CR1	7490.0	1033.0
CXCL10	-1428.0	6945.0
CXCL11	-3354.0	755.0
CXCL12	-167.0	-5064.0
CXCL13	-983.0	2137.0
CXCL16	-1416.0	1796.0
CXCL6	1725.0	-120.0
CXCL9	-4586.0	-1172.0
CXCR1	-8332.0	3339.0
CXCR3	-8048.0	6329.0
CXCR4	-4955.0	6159.0
CXCR5	-6205.0	233.0
CXCR6	-8072.0	5815.0
CYP4V2	-2489.0	3792.0
CYSLTR1	7731.0	8257.0
DAGLA	-1577.0	-2865.0
DAGLB	-7593.0	-5494.0
DGKA	4362.0	-888.0
DGKB	-7274.0	2006.0
DGKD	-252.0	5175.0
DGKE	-8471.0	-7292.0
DGKG	-7037.0	6105.0
DGKH	-3937.0	-4819.0
DGKI	7097.0	8386.0
DGKQ	1613.0	-3144.0
DGKZ	-7880.0	-1598.0
DHRS3	-4170.0	1783.0
DHRS9	7029.0	428.0
DRD1	7719.0	-5415.0
DRD3	1360.0	-7155.0
DRD4	5323.0	-600.0
DRD5	-867.5	2933.5
ECT2	7057.0	-8411.0
EDN1	-3063.0	-1167.0
EDN2	7212.0	7400.0
EDN3	-7499.0	1560.5
EDNRA	-8720.0	-8520.0
EDNRB	-1198.0	6163.0
EGFR	-1421.0	-7571.0
F2	-3364.0	634.0
F2R	3097.0	1369.0
F2RL1	489.0	6968.0
F2RL2	-1619.0	-3842.0
F2RL3	695.0	884.0
FFAR2	5230.0	-4510.0
FFAR3	742.0	-670.5
FFAR4	1003.0	-1075.0
FGD1	-5714.0	-2785.0
FGD2	3891.0	-3853.0
FGD3	5965.0	-6604.0
FGD4	-5928.0	-8014.0
FNTA	7191.0	5965.0
FNTB	-4262.5	1541.5
FPR1	-1988.0	-5296.0
FPR2	-4218.5	3162.5
FPR3	-4218.5	3162.5
GABBR1	-8785.0	-8232.0
GABBR2	6853.0	-1654.0
GAL	-4576.0	1777.0
GALR1	-1287.0	5472.0
GALR2	-7934.0	-8182.0
GALR3	1728.0	6994.0
GHRH	885.0	-892.0
GHRHR	-3659.0	7514.0
GHRL	4173.0	3325.0
GHSR	-1585.0	-670.5
GIPR	5107.0	-2670.0
GLP1R	8271.0	-6324.0
GLP2R	-7794.0	4919.0
GNA11	-2620.0	601.0
GNA12	2869.0	3191.0
GNA13	4996.0	-3534.0
GNA14	-6709.0	6831.0
GNA15	86.0	-5622.0
GNAI1	-7376.0	5037.0
GNAI2	-4164.0	-1806.0
GNAI3	3460.0	-7071.0
GNAL	-6848.0	-6045.0
GNAO1	-4885.0	3280.0
GNAS	-8325.0	6344.0
GNAT1	3151.0	-1339.0
GNAT2	-5007.0	-6197.0
GNAT3	1097.0	7559.0
GNAZ	5963.0	-1529.0
GNB1	-3640.0	-6683.0
GNB2	5974.0	-7330.0
GNB3	7638.0	7679.0
GNB4	-4332.0	-7844.0
GNB5	-107.0	-6520.0
GNG10	6819.0	-2589.0
GNG11	3479.0	-2086.0
GNG12	-5616.0	-1630.0
GNG13	-1861.0	-5806.0
GNG2	6500.0	-4950.0
GNG3	3036.0	-91.0
GNG4	-7043.0	-588.0
GNG5	826.0	6410.0
GNG7	-2816.0	-6814.0
GNG8	6323.0	6548.0
GNGT2	4096.0	4482.0
GNRH1	485.0	-2836.0
GNRHR	-3373.0	-3215.0
GPBAR1	7136.0	3575.0
GPC1	3367.0	6196.0
GPC2	-3314.0	5398.0
GPC3	-1882.0	-3616.0
GPC4	-6887.0	1767.0
GPC6	-1169.0	-3182.0
GPER1	7614.0	-2053.0
GPHA2	2515.0	510.0
GPHB5	-323.0	4187.0
GPIHBP1	-3154.0	-5543.0
GPR132	-5990.0	-6738.0
GPR143	-996.0	-4049.0
GPR15	1416.0	7785.0
GPR17	549.0	2465.0
GPR176	-1627.0	7275.0
GPR18	5473.0	4686.0
GPR183	-2946.0	-1155.0
GPR25	3595.0	5626.0
GPR27	-7428.0	5812.0
GPR31	-2997.0	6423.0
GPR37	4646.0	-4602.0
GPR37L1	-27.0	-6533.0
GPR39	-6508.0	-2139.0
GPR4	-3932.0	4912.0
GPR45	-1019.0	526.0
GPR55	-1567.0	301.0
GPR65	-16.0	5231.0
GPR68	2471.0	-3237.0
GPR83	1351.0	-6253.0
GPR84	-3219.0	-5318.0
GPRC6A	1640.5	-670.5
GPSM1	6611.0	8623.0
GPSM2	-955.0	-6556.0
GPSM3	-7859.0	1117.0
GRB2	-3087.0	5476.0
GRK1	1388.0	-1499.0
GRK2	1007.0	-1571.0
GRK3	-7089.0	-7563.0
GRK4	3350.0	6835.0
GRK5	2229.0	-3389.0
GRK6	-8236.0	-5823.0
GRM1	6207.0	-6548.0
GRM2	1002.0	-4152.0
GRM3	564.0	-961.0
GRM5	-4438.0	-4028.5
GRM6	-1061.0	1078.0
GRM7	7056.0	3516.0
GRM8	-3665.0	215.0
GRPR	-3901.0	5661.0
GUCA1A	6773.0	-6576.0
GUCA1B	-2883.0	5205.0
GUCY2D	1560.0	-1256.0
GUCY2F	2734.0	2899.0
HBEGF	4336.0	-4812.0
HCAR1	2955.0	-3523.0
HCAR2	2601.5	-7764.5
HCAR3	2601.5	-7764.5
HCRT	2549.0	862.5
HCRTR1	-588.0	-6145.0
HCRTR2	4914.0	-5685.0
HEBP1	-2880.0	1075.0
HRAS	-2027.0	8503.0
HRH1	3519.0	-5307.0
HRH2	7900.0	-4228.0
HRH4	1579.0	5347.0
HSD17B1	7846.0	1299.0
HSD17B6	-6318.0	-7545.0
HSPG2	-3510.0	-2622.0
HTR1B	4348.0	-7389.0
HTR1D	7559.5	1839.5
HTR1F	-3830.0	-2161.0
HTR2A	5361.0	-4472.0
HTR2B	1881.0	-7472.0
HTR4	-1057.0	-8149.0
HTR7	-6211.0	-8496.0
IAPP	181.5	838.5
ITPR1	8605.0	-5457.0
ITPR2	-5569.0	-4498.0
ITPR3	-5778.0	-4615.0
ITSN1	-8102.0	-5900.0
KALRN	-156.0	8062.0
KISS1	-1881.0	1964.0
KISS1R	6453.0	5796.0
KNG1	-8772.0	-8546.0
KPNA2	7880.0	-3492.0
KRAS	5560.0	-6672.0
LDLR	2690.0	-7724.0
LHCGR	237.5	-626.0
LPAR1	3098.0	-5711.0
LPAR2	8068.0	-8338.0
LPAR3	6948.0	-7602.0
LPAR4	6770.0	1338.0
LPAR5	-7773.0	-5264.0
LPAR6	-3764.0	-3332.0
LPL	-2238.0	3473.0
LRAT	-4187.0	-8008.0
LRP1	4525.0	-3430.0
LRP10	-3049.0	1097.0
LRP12	7377.0	6292.0
LRP2	-5280.0	-5955.0
LRP8	1858.0	2029.0
LTB4R	-1961.0	234.0
LTB4R2	6674.0	5146.0
MAPK1	1821.0	-516.0
MAPK3	2277.0	2915.0
MAPK7	4442.0	-7552.0
MC2R	1930.0	-5097.0
MC3R	181.5	-670.5
MC4R	7971.0	3408.0
MC5R	-4127.0	7840.0
MCF2	-7412.0	-531.0
MCF2L	-7244.0	7750.0
MCHR1	-3636.0	-56.0
METAP1	-1313.0	-3522.0
METAP2	4889.0	3851.0
MGLL	-7308.0	-7146.0
MMP3	7257.0	-6705.0
MTNR1A	-867.5	810.5
MYO7A	3391.0	5614.0
NAPEPLD	5936.0	8482.0
NET1	-4723.0	-1696.0
NGEF	-4590.0	-3655.0
NMB	3423.0	-4402.0
NMBR	5233.0	792.0
NMT1	296.0	7716.0
NMT2	-3812.0	-760.0
NMU	4241.0	-5547.0
NMUR1	-4753.0	-5489.0
NMUR2	6855.0	-1499.0
NPB	-3566.0	3911.0
NPFF	-1812.0	2875.0
NPFFR1	-7609.0	3959.0
NPSR1	-1277.0	-4562.0
NPW	-4490.0	-955.0
NPY	-7775.0	3479.0
NPY1R	-7739.0	-1346.0
NPY4R	334.5	-1403.5
NRAS	1555.0	-7507.0
NTS	-7592.0	2138.0
NTSR1	-8450.0	2496.0
NTSR2	7875.0	-6085.0
OBSCN	-8298.0	-460.0
OPN1LW	-1861.0	-2180.0
OPN1MW	-1861.0	-2180.0
OPN1SW	7823.0	996.0
OPN3	8120.0	3804.0
OPN4	435.0	4831.0
OPN5	756.0	-626.0
OPRD1	-166.0	-966.0
OPRK1	6564.0	85.0
OPRL1	-664.0	142.0
OPRM1	8454.0	8879.0
OR10G2	-1991.0	1560.5
OR10G3	-275.0	-4884.0
OR10H1	908.5	-3428.5
OR10H5	908.5	-3428.5
OR10K1	-1607.0	-2675.0
OR10V1	-1377.0	-1620.0
OR11A1	-1614.0	-2180.0
OR13J1	181.5	-2913.0
OR14J1	-1377.0	-1499.0
OR1F1	5487.0	-2601.0
OR1I1	-1377.0	1579.0
OR1J1	181.5	-1499.0
OR1N1	-117.0	-1065.0
OR1Q1	-1377.0	6549.0
OR2A1	-867.5	899.5
OR2A14	181.5	945.0
OR2AG1	571.0	-3811.0
OR2AG2	1207.5	2759.0
OR2AT4	1992.0	7054.0
OR2B11	-827.0	-2156.0
OR2B2	311.0	3474.0
OR2F1	-1637.5	-3555.5
OR2F2	-1637.5	-3555.5
OR2H1	-827.0	4363.5
OR2H2	-827.0	4363.5
OR2K2	6156.0	-4261.0
OR2T29	-819.0	-7413.0
OR2T4	-819.0	-7413.0
OR2T5	-819.0	-7413.0
OR2V1	742.0	6773.0
OR2V2	754.0	-5294.0
OR2Y1	181.5	-729.0
OR2Z1	754.0	810.5
OR4B1	-1195.0	-670.5
OR4C6	-867.5	-6574.0
OR4E1	6227.0	-2368.0
OR4F6	-275.0	838.5
OR4M1	721.5	810.5
OR4M2	721.5	810.5
OR4N5	1317.0	838.5
OR51D1	4416.0	3915.0
OR51E1	-6575.0	-2247.0
OR51E2	-3024.0	-6889.0
OR51F1	181.5	838.5
OR52B2	-3568.0	2219.0
OR52E6	710.0	-670.5
OR52E8	710.0	-670.5
OR52I1	-5765.5	-3985.5
OR52I2	-5765.5	-3985.5
OR52L1	181.5	1634.0
OR52N2	-666.5	-1416.0
OR52W1	-7604.0	5475.0
OR56B4	-1377.0	7096.0
OR5AK2	-1355.0	-3677.5
OR5AK3P	-1355.0	-3677.5
OR5C1	242.0	-4343.0
OR5G3	-1548.5	-3387.0
OR5H1	-461.0	1640.5
OR5H14	-461.0	1640.5
OR5H15	-461.0	1640.5
OR5H6	-461.0	1640.5
OR5P2	-1796.0	7457.0
OR6B2	6.5	-2180.0
OR6B3	6.5	-2180.0
OR6C70	2066.0	5361.0
OR6K2	5000.0	3603.0
OR6K3	1810.0	-5308.0
OR6K6	-5066.0	-2008.0
OR6N1	5975.0	-5447.0
OR6N2	-4873.0	-6751.0
OR6S1	-5701.0	614.0
OR6X1	181.5	-1499.0
OR7E24	-1849.0	-1419.0
OR7G1	-867.5	-5697.0
OR7G2	-666.5	110.0
OR8G1	-2149.5	208.5
OR8G5	-2149.5	208.5
OR9A4	-275.0	2248.0
OR9K2	-867.5	944.0
OXT	337.0	5592.0
OXTR	4992.0	-1145.0
P2RY1	6656.0	4049.0
P2RY10	-4675.0	3120.0
P2RY12	2088.0	-5749.0
P2RY13	7352.0	1973.0
P2RY14	-8397.0	-4441.0
P2RY2	-2186.0	-5109.0
P2RY4	3220.0	-3917.0
P2RY6	-5372.0	6897.0
PAK1	-8756.0	-7874.0
PCP2	-5732.0	7613.0
PDE10A	5206.0	-3074.0
PDE11A	-8566.0	1978.0
PDE1A	3081.0	-5361.0
PDE1B	-8152.0	-5932.0
PDE1C	-7328.0	-8536.0
PDE2A	-8637.0	-1170.0
PDE3A	3521.0	-2301.0
PDE3B	1441.0	-6631.0
PDE4A	-4371.0	3271.0
PDE4B	6975.0	7351.0
PDE4C	-7717.5	2744.5
PDE4D	-8678.0	-1667.0
PDE6A	-4282.0	-4130.0
PDE6B	-408.0	-5598.0
PDE6G	7972.0	-6160.0
PDE7A	8556.0	-2532.0
PDE7B	-5141.0	4089.0
PDE8A	3902.0	5039.0
PDE8B	2768.5	-6469.5
PDPK1	-4064.0	4848.0
PDYN	2874.0	2632.0
PENK	-2046.0	6173.0
PIK3CA	82.0	-3696.0
PIK3CG	6551.0	-4399.0
PIK3R1	7815.0	4899.0
PIK3R2	-6826.5	1491.5
PIK3R3	470.5	349.5
PIK3R5	-5218.0	-5522.0
PIK3R6	-5980.0	-2943.0
PLA2G4A	8255.0	-2638.0
PLB1	-8120.0	7640.0
PLCB1	-3795.0	4753.0
PLCB2	6897.0	-6276.0
PLCB3	-7682.0	3196.0
PLCB4	-8101.0	8738.0
PLEKHG2	-6933.0	-8004.0
PLEKHG5	-8179.0	3086.0
PLXNB1	-1136.0	3245.0
PMCH	5599.0	572.0
PNLIP	1669.0	838.5
PNOC	7643.0	-5531.0
POMC	2992.0	4075.0
PPBP	-2248.0	-3369.0
PPEF1	557.0	5141.0
PPP1CA	-5613.0	8001.0
PPP1R1B	3579.0	7098.0
PPP2CA	-5989.0	-1036.0
PPP2CB	-3379.0	-1146.0
PPP2R1A	-3227.0	6730.0
PPP2R1B	4232.0	3139.0
PPP2R5D	469.0	5899.0
PPP3CA	-2422.0	-5921.0
PPP3CB	-680.0	1841.0
PPP3CC	-8201.0	7977.0
PPP3R1	4773.5	-1941.5
PREX1	-2801.0	1977.0
PRKACA	-7439.0	7145.0
PRKACB	-6436.0	1450.0
PRKAR1A	-4709.0	5819.0
PRKAR1B	7738.0	1273.0
PRKAR2A	-7831.0	8145.0
PRKAR2B	-8604.0	-8020.0
PRKCA	-1604.0	-4833.0
PRKCB	2372.0	-8162.0
PRKCD	1334.0	5533.0
PRKCE	-6856.0	4958.0
PRKCG	-2544.0	-1021.0
PRKCH	-4886.5	1334.5
PRKCQ	-3233.0	-5957.0
PRKX	5161.5	-4247.5
PROK1	-867.5	2985.0
PROK2	1591.0	4196.5
PROKR2	-3965.0	-940.0
PSAP	-6404.0	5173.0
PTAFR	3950.0	-5186.0
PTGDR	5730.0	-5459.0
PTGDR2	-5770.0	-3784.0
PTGER1	-4963.0	2824.0
PTGER2	-6605.0	-5802.0
PTGER3	-8647.0	-4662.0
PTGER4	-7272.0	-2067.0
PTGFR	6591.0	6001.0
PTGIR	-3062.0	6837.0
PTH1R	-5288.0	-5177.0
PTH2R	181.5	-1499.0
PYY	721.5	-3217.0
QRFP	910.0	4775.0
QRFPR	-7702.0	-6995.0
RAMP1	-5390.0	2891.0
RAMP2	-5805.0	1740.0
RAMP3	4822.0	866.0
RASGRF2	4935.0	3443.0
RASGRP1	6707.0	2181.0
RASGRP2	-7077.0	5360.0
RBP1	-6704.0	-3493.0
RBP2	-867.5	317.0
RBP3	4574.0	-5707.0
RBP4	-7903.0	-1898.0
RCVRN	-4839.0	-6488.0
RDH10	4715.0	-5980.0
RDH11	8310.5	6795.5
RDH12	6109.0	4333.0
RDH16	-8774.0	5953.0
RDH5	6224.0	-6063.0
RDH8	-5806.0	-1954.0
REEP1	-229.0	6849.0
REEP2	-2035.0	3.0
REEP3	-8.0	-4051.0
REEP4	6172.0	1480.0
REEP5	-190.0	6252.0
REEP6	-5935.0	-2027.0
RETSAT	-542.0	6311.0
RGR	-3217.0	-670.5
RGS1	-1921.0	-7143.0
RGS10	4166.0	-257.0
RGS12	6440.0	-6473.0
RGS13	-1094.0	-6464.0
RGS14	-8300.0	5448.0
RGS16	678.0	-828.0
RGS17	-8496.0	-6323.0
RGS18	-111.0	-17.0
RGS19	5379.0	1419.0
RGS2	-7527.0	-887.0
RGS20	-8241.0	6747.0
RGS21	181.5	-262.0
RGS22	2259.0	-3905.0
RGS3	-4230.0	8458.0
RGS4	-619.0	-2904.0
RGS5	-8254.0	3797.0
RGS6	-8182.0	3016.0
RGS7	3146.0	-3095.0
RGS8	-6769.0	-8429.0
RGS9	4793.0	-2317.0
RGS9BP	4132.0	5276.0
RGSL1	4979.0	1163.0
RHO	-3722.0	-6540.0
RHOA	-580.0	1949.0
RHOB	-2836.0	893.0
RHOC	5220.5	1265.5
RLBP1	-4969.0	-5356.0
RLN2	4043.5	3745.5
RLN3	-1894.0	-3257.0
ROCK1	4677.0	-5373.0
ROCK2	-3144.0	-739.0
RPE65	6781.0	-7627.0
RPS6KA1	-8334.0	3660.0
RPS6KA2	1099.0	3485.0
RPS6KA3	-3445.0	-1615.0
RRH	-8492.0	-8454.0
RTP1	181.5	3669.0
RTP3	-6814.0	-5560.0
RTP4	1917.0	-353.0
RXFP1	-3204.0	3113.0
RXFP2	-7357.0	-1535.0
S1PR2	5338.0	-7215.0
S1PR3	6834.0	565.0
S1PR4	-6316.0	-1887.0
S1PR5	5308.0	-5548.0
SAG	-8731.0	-8503.0
SCT	2176.0	7250.0
SCTR	1745.0	6278.0
SDC1	7023.0	-7120.0
SDC2	6159.0	-6681.0
SDC3	-1826.0	1368.0
SDC4	-2743.0	-3481.0
SDR9C7	3288.0	-7652.0
SLC24A1	3754.0	-3497.0
SOS1	-2568.0	1190.0
SOS2	7364.0	-8297.0
SRC	-7820.0	-2286.0
SSTR1	-6035.0	107.0
SSTR2	1116.0	3144.0
SSTR3	-3727.0	-5360.0
SSTR4	-4776.0	2241.0
SSTR5	-2559.5	1634.0
STRA6	6219.0	1122.0
SUCNR1	-5514.0	1765.0
TAAR8	181.5	-3625.0
TAC1	571.0	-6331.0
TAC3	-5919.0	-5727.0
TACR1	-5779.0	6250.0
TACR2	-5223.0	3951.0
TACR3	-5705.0	-1735.0
TAS1R1	6519.0	7099.0
TAS1R2	-8764.0	8577.0
TAS1R3	-8475.0	6729.0
TAS2R13	765.0	-6702.0
TAS2R14	-1344.0	1560.5
TAS2R19	425.0	-303.0
TAS2R20	425.0	-303.0
TAS2R3	-3894.0	1843.0
TAS2R30	425.0	-303.0
TAS2R31	425.0	-303.0
TAS2R4	139.0	5573.0
TAS2R41	5854.0	388.0
TAS2R43	425.0	-303.0
TAS2R46	425.0	-303.0
TAS2R50	425.0	-303.0
TAS2R60	-4349.0	-2106.0
TAS2R7	181.5	-1499.0
TBXA2R	2560.0	578.0
TIAM1	6649.0	-6513.0
TIAM2	4557.0	-3250.0
TRH	-8042.0	-8132.0
TRHR	-1239.0	-1139.0
TRIO	-6078.0	-276.0
TRPC3	8412.0	-8522.0
TRPC6	7914.0	-6802.0
TRPC7	4465.0	-4184.0
TSHB	-5052.0	2159.0
TSHR	-6228.0	-6642.0
TTR	-8563.0	-2206.0
UTS2	-3543.0	-6199.0
VAV1	1672.0	-7291.0
VAV2	5524.0	8208.0
VAV3	-6816.0	-7178.0
VIP	-7808.0	-7758.0
VIPR1	-7988.0	-1820.0
VIPR2	6089.0	-2150.0
XCL1	1182.5	-3585.5
XCL2	1182.5	-3585.5
XCR1	-4322.0	-3129.0

---

---

Metabolism of polyamines

Metabolism of polyamines

metric	value
setSize	57
pMANOVA	5.62e-07
p.adjustMANOVA	2.7e-05
s.dist	0.408
s.skel	0.0852
s.heart	0.399
p.skel	0.266
p.heart	1.85e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
ODC1	8188.0	6746.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
AMD1	6071.0	5558.0
PSMC2	5868.0	5306.0
AZIN2	6512.0	4372.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
AZIN1	8220.0	2419.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0

Click HERE to show all gene set members

All member genes

	skel	heart
AGMAT	4564.0	-4477.0
AMD1	6071.0	5558.0
AZIN1	8220.0	2419.0
AZIN2	6512.0	4372.0
NQO1	-1479.0	4949.0
OAZ1	-3500.0	2116.0
OAZ2	-7799.0	5052.0
OAZ3	-1166.0	338.0
ODC1	8188.0	6746.0
PAOX	-1449.5	7587.5
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
SAT1	7936.0	-5283.0
SMOX	-5260.0	-1428.0
SMS	-3396.0	-1117.0
SRM	-756.0	7112.0

---

---

Cross-presentation of soluble exogenous antigens (endosomes)

Cross-presentation of soluble exogenous antigens (endosomes)

metric	value
setSize	48
pMANOVA	5.75e-07
p.adjustMANOVA	2.7e-05
s.dist	0.444
s.skel	0.0935
s.heart	0.434
p.skel	0.262
p.heart	1.91e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
PSME4	2756.0	5110.0
FCGR1A	1784.5	7590.5
FCGR1B	1784.5	7590.5
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0
PSMA1	2067.0	1803.0
PSMD14	546.0	6040.0

Click HERE to show all gene set members

All member genes

	skel	heart
CD207	-867.5	3974.0
FCGR1A	1784.5	7590.5
FCGR1B	1784.5	7590.5
MRC1	6280.0	-411.0
MRC2	5159.0	-2763.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0

---

---

Signaling by GPCR

Signaling by GPCR

metric	value
setSize	772
pMANOVA	5.92e-07
p.adjustMANOVA	2.7e-05
s.dist	0.112
s.skel	-0.0653
s.heart	-0.0912
p.skel	0.00212
p.heart	1.76e-05

Top 20 genes

Gene	skel	heart
KNG1	-8772	-8546
EDNRA	-8720	-8520
SAG	-8731	-8503
GABBR1	-8785	-8232
RRH	-8492	-8454
CCL28	-8498	-8354
WNT4	-8479	-8272
PRKAR2B	-8604	-8020
PAK1	-8756	-7874
APOC3	-8626	-7683
TRH	-8042	-8132
GALR2	-7934	-8182
PDE1C	-7328	-8536
DGKE	-8471	-7292
ABR	-7381	-8288
VIP	-7808	-7758
ARHGEF1	-8442	-6904
RGS8	-6769	-8429
PLEKHG2	-6933	-8004
QRFPR	-7702	-6995

Click HERE to show all gene set members

All member genes

	skel	heart
ABCA4	7012.0	3963.0
ABHD12	-7223.0	7187.0
ABHD6	8035.0	3611.0
ABR	-7381.0	-8288.0
ACKR2	7295.0	-1182.0
ACKR3	6004.0	-1276.0
ACKR4	-3117.0	1166.0
ADCY1	-3786.0	223.0
ADCY2	-6164.0	-5813.0
ADCY3	1385.0	-6913.0
ADCY4	-6488.0	1986.0
ADCY5	-2115.0	3615.0
ADCY6	-6611.0	275.0
ADCY7	1963.0	-3579.0
ADCY8	6532.0	4755.0
ADCY9	-1608.0	173.0
ADCYAP1	449.0	-7339.0
ADCYAP1R1	6896.0	-8453.0
ADGRE1	5174.0	-3314.0
ADGRE5	-4583.0	7173.0
ADM	1398.0	7703.0
ADM2	-1861.0	1862.0
ADORA1	-8395.0	8761.0
ADORA2A	-2406.0	6044.0
ADORA2B	-7264.0	4410.0
ADORA3	7825.0	8057.0
ADRA1A	6281.0	3558.0
ADRA1B	3667.0	6004.0
ADRA1D	-4122.0	4066.0
ADRA2A	4300.0	3775.0
ADRA2B	-7216.0	-2923.0
ADRA2C	4641.0	4450.0
ADRB1	3339.0	1172.0
ADRB2	2580.0	-3113.0
ADRB3	-7712.5	6766.5
AGRN	-978.0	-4541.0
AGT	-7588.0	-5820.0
AGTR1	-5316.0	-6949.0
AGTR2	7198.0	4973.0
AHCYL1	7434.0	-3277.0
AKAP13	-4927.0	378.0
AKR1B10	-8633.0	8691.0
AKT1	1272.0	5976.0
AKT2	-5690.0	1098.0
AKT3	8315.0	728.0
ANXA1	6844.0	-3114.0
APLN	-2309.0	-1586.0
APLNR	-4521.0	766.0
APOA1	-488.0	3512.0
APOA2	-7127.0	-5091.0
APOA4	-6487.0	-3735.0
APOB	446.0	-8252.0
APOC2	-7258.5	203.5
APOC3	-8626.0	-7683.0
APOE	-8560.0	-6177.0
APOM	1430.0	-8376.0
APP	7187.0	7687.0
ARHGEF1	-8442.0	-6904.0
ARHGEF10	-703.0	-2723.0
ARHGEF10L	-6353.0	8511.0
ARHGEF11	-8012.0	6720.0
ARHGEF12	5814.0	3188.0
ARHGEF15	-412.0	-1943.0
ARHGEF16	-7393.0	-6440.0
ARHGEF17	-6614.0	-6444.0
ARHGEF18	-2314.5	-1319.5
ARHGEF19	-5281.0	-2648.0
ARHGEF2	7686.0	-8540.0
ARHGEF25	5676.5	5393.5
ARHGEF26	8008.0	-5941.0
ARHGEF3	7338.0	898.0
ARHGEF33	-393.0	5184.0
ARHGEF37	-8558.0	5629.0
ARHGEF38	-4301.0	-1690.0
ARHGEF39	-1107.0	-5839.0
ARHGEF40	-7425.0	-3732.0
ARHGEF5	-7020.0	389.0
ARHGEF6	-5048.0	-2677.0
ARHGEF7	-8259.0	2371.0
ARRB1	-23.0	757.0
ARRB2	-6483.0	-1323.0
AVP	3002.0	2838.0
AVPR1A	50.0	-7417.0
AVPR1B	5291.0	4509.0
AVPR2	-6697.0	-7226.0
AWAT2	7752.0	-7273.0
BCO1	3610.0	-225.0
BCO2	5768.0	-7653.0
BDKRB1	3289.0	-3489.0
BDKRB2	-3799.0	-7975.0
BRS3	-403.0	-4671.0
BTK	7270.0	-7309.0
C3	-6034.0	-8192.0
C3AR1	-3619.0	-5812.0
C5	-8782.0	5917.0
C5AR1	-1115.0	4385.0
C5AR2	6116.0	-2075.0
CALCA	4552.0	-7312.0
CALCR	-670.0	5387.0
CALCRL	7677.0	-7290.0
CALM1	-82.0	3278.0
CAMK2A	-3643.0	7280.0
CAMK2B	-8620.0	8181.0
CAMK2G	7184.0	5782.0
CAMK4	983.0	6639.0
CAMKK1	4428.0	-3016.0
CAMKK2	-179.0	-5551.0
CAMKMT	2648.0	-7900.0
CASR	-1126.0	-5630.0
CCK	3991.0	-5191.0
CCKAR	-1861.0	405.0
CCKBR	-1539.0	4606.0
CCL11	-8212.0	-1243.0
CCL17	-2524.0	6157.0
CCL19	-6442.0	-1589.0
CCL2	-2395.0	456.0
CCL21	6892.0	-3239.0
CCL22	-4840.0	-7626.0
CCL23	2923.0	-7957.0
CCL27	4572.0	-6127.0
CCL28	-8498.0	-8354.0
CCL3	795.0	-1649.0
CCL4	-3531.5	-6954.5
CCL7	7876.0	-2063.0
CCR1	2814.0	-8123.0
CCR10	-577.0	4352.0
CCR3	-3135.0	3186.0
CCR4	-1861.0	45.0
CCR5	7329.0	-7615.0
CCR6	-4192.0	-5018.0
CCR7	-1074.0	2865.0
CCR8	3847.0	-4718.0
CCR9	-6729.0	-4099.0
CCRL2	3228.0	6592.0
CD55	-2975.0	4811.0
CDC42	-8165.0	-2736.0
CDK5	-2367.0	-1608.0
CGA	-260.5	810.5
CHRM1	-3424.0	1980.0
CHRM2	-827.0	2930.0
CHRM3	-8036.0	-4250.0
CHRM4	-6017.0	-6888.0
CHRM5	-6910.0	3353.0
CMKLR1	5440.0	-2934.0
CNGA1	181.5	4321.0
CNGB1	8049.0	-8484.0
CNR1	-6972.0	-7037.0
CNR2	-6500.0	4820.0
CREB1	8140.0	3609.0
CRH	6039.0	7140.0
CRHBP	-4541.0	5271.0
CRHR1	1517.0	2315.0
CRHR2	-8755.0	7004.0
CX3CL1	-2019.0	-1910.0
CX3CR1	7490.0	1033.0
CXCL10	-1428.0	6945.0
CXCL11	-3354.0	755.0
CXCL12	-167.0	-5064.0
CXCL13	-983.0	2137.0
CXCL16	-1416.0	1796.0
CXCL6	1725.0	-120.0
CXCL9	-4586.0	-1172.0
CXCR1	-8332.0	3339.0
CXCR3	-8048.0	6329.0
CXCR4	-4955.0	6159.0
CXCR5	-6205.0	233.0
CXCR6	-8072.0	5815.0
CYP4V2	-2489.0	3792.0
CYSLTR1	7731.0	8257.0
DAGLA	-1577.0	-2865.0
DAGLB	-7593.0	-5494.0
DGKA	4362.0	-888.0
DGKB	-7274.0	2006.0
DGKD	-252.0	5175.0
DGKE	-8471.0	-7292.0
DGKG	-7037.0	6105.0
DGKH	-3937.0	-4819.0
DGKI	7097.0	8386.0
DGKQ	1613.0	-3144.0
DGKZ	-7880.0	-1598.0
DHH	1912.0	-1752.0
DHRS3	-4170.0	1783.0
DHRS9	7029.0	428.0
DRD1	7719.0	-5415.0
DRD2	1937.0	-1419.0
DRD3	1360.0	-7155.0
DRD4	5323.0	-600.0
DRD5	-867.5	2933.5
ECE1	-6478.0	3995.0
ECE2	3854.5	-3662.5
ECT2	7057.0	-8411.0
EDN1	-3063.0	-1167.0
EDN2	7212.0	7400.0
EDN3	-7499.0	1560.5
EDNRA	-8720.0	-8520.0
EDNRB	-1198.0	6163.0
EGFR	-1421.0	-7571.0
F2	-3364.0	634.0
F2R	3097.0	1369.0
F2RL1	489.0	6968.0
F2RL2	-1619.0	-3842.0
F2RL3	695.0	884.0
FFAR2	5230.0	-4510.0
FFAR3	742.0	-670.5
FFAR4	1003.0	-1075.0
FGD1	-5714.0	-2785.0
FGD2	3891.0	-3853.0
FGD3	5965.0	-6604.0
FGD4	-5928.0	-8014.0
FNTA	7191.0	5965.0
FNTB	-4262.5	1541.5
FPR1	-1988.0	-5296.0
FPR2	-4218.5	3162.5
FPR3	-4218.5	3162.5
FZD1	4328.0	-3566.0
FZD2	5745.0	2580.0
FZD3	-5795.0	5129.0
FZD4	1815.0	-4202.0
FZD5	4888.0	210.0
FZD6	4757.0	-6789.0
FZD7	-2059.0	-2856.0
FZD8	4291.0	-3185.0
FZD9	-319.0	-4914.0
GABBR1	-8785.0	-8232.0
GABBR2	6853.0	-1654.0
GAL	-4576.0	1777.0
GALR1	-1287.0	5472.0
GALR2	-7934.0	-8182.0
GALR3	1728.0	6994.0
GHRH	885.0	-892.0
GHRHR	-3659.0	7514.0
GHRL	4173.0	3325.0
GHSR	-1585.0	-670.5
GIPR	5107.0	-2670.0
GLP1R	8271.0	-6324.0
GLP2R	-7794.0	4919.0
GNA11	-2620.0	601.0
GNA12	2869.0	3191.0
GNA13	4996.0	-3534.0
GNA14	-6709.0	6831.0
GNA15	86.0	-5622.0
GNAI1	-7376.0	5037.0
GNAI2	-4164.0	-1806.0
GNAI3	3460.0	-7071.0
GNAL	-6848.0	-6045.0
GNAO1	-4885.0	3280.0
GNAS	-8325.0	6344.0
GNAT1	3151.0	-1339.0
GNAT2	-5007.0	-6197.0
GNAT3	1097.0	7559.0
GNAZ	5963.0	-1529.0
GNB1	-3640.0	-6683.0
GNB2	5974.0	-7330.0
GNB3	7638.0	7679.0
GNB4	-4332.0	-7844.0
GNB5	-107.0	-6520.0
GNG10	6819.0	-2589.0
GNG11	3479.0	-2086.0
GNG12	-5616.0	-1630.0
GNG13	-1861.0	-5806.0
GNG2	6500.0	-4950.0
GNG3	3036.0	-91.0
GNG4	-7043.0	-588.0
GNG5	826.0	6410.0
GNG7	-2816.0	-6814.0
GNG8	6323.0	6548.0
GNGT2	4096.0	4482.0
GNRH1	485.0	-2836.0
GNRHR	-3373.0	-3215.0
GPBAR1	7136.0	3575.0
GPC1	3367.0	6196.0
GPC2	-3314.0	5398.0
GPC3	-1882.0	-3616.0
GPC4	-6887.0	1767.0
GPC6	-1169.0	-3182.0
GPER1	7614.0	-2053.0
GPHA2	2515.0	510.0
GPHB5	-323.0	4187.0
GPIHBP1	-3154.0	-5543.0
GPR132	-5990.0	-6738.0
GPR143	-996.0	-4049.0
GPR15	1416.0	7785.0
GPR17	549.0	2465.0
GPR176	-1627.0	7275.0
GPR18	5473.0	4686.0
GPR183	-2946.0	-1155.0
GPR25	3595.0	5626.0
GPR27	-7428.0	5812.0
GPR31	-2997.0	6423.0
GPR35	-986.0	-2036.0
GPR37	4646.0	-4602.0
GPR37L1	-27.0	-6533.0
GPR39	-6508.0	-2139.0
GPR4	-3932.0	4912.0
GPR45	-1019.0	526.0
GPR55	-1567.0	301.0
GPR65	-16.0	5231.0
GPR68	2471.0	-3237.0
GPR83	1351.0	-6253.0
GPR84	-3219.0	-5318.0
GPRC6A	1640.5	-670.5
GPSM1	6611.0	8623.0
GPSM2	-955.0	-6556.0
GPSM3	-7859.0	1117.0
GRB2	-3087.0	5476.0
GRK1	1388.0	-1499.0
GRK2	1007.0	-1571.0
GRK3	-7089.0	-7563.0
GRK4	3350.0	6835.0
GRK5	2229.0	-3389.0
GRK6	-8236.0	-5823.0
GRM1	6207.0	-6548.0
GRM2	1002.0	-4152.0
GRM3	564.0	-961.0
GRM5	-4438.0	-4028.5
GRM6	-1061.0	1078.0
GRM7	7056.0	3516.0
GRM8	-3665.0	215.0
GRPR	-3901.0	5661.0
GUCA1A	6773.0	-6576.0
GUCA1B	-2883.0	5205.0
GUCY2D	1560.0	-1256.0
GUCY2F	2734.0	2899.0
HBEGF	4336.0	-4812.0
HCAR1	2955.0	-3523.0
HCAR2	2601.5	-7764.5
HCAR3	2601.5	-7764.5
HCRT	2549.0	862.5
HCRTR1	-588.0	-6145.0
HCRTR2	4914.0	-5685.0
HEBP1	-2880.0	1075.0
HRAS	-2027.0	8503.0
HRH1	3519.0	-5307.0
HRH2	7900.0	-4228.0
HRH3	4503.0	-2920.0
HRH4	1579.0	5347.0
HSD17B1	7846.0	1299.0
HSD17B6	-6318.0	-7545.0
HSPG2	-3510.0	-2622.0
HTR1A	7559.5	1839.5
HTR1B	4348.0	-7389.0
HTR1D	7559.5	1839.5
HTR1F	-3830.0	-2161.0
HTR2A	5361.0	-4472.0
HTR2B	1881.0	-7472.0
HTR4	-1057.0	-8149.0
HTR7	-6211.0	-8496.0
IAPP	181.5	838.5
IHH	-7214.0	2220.0
ITPR1	8605.0	-5457.0
ITPR2	-5569.0	-4498.0
ITPR3	-5778.0	-4615.0
ITSN1	-8102.0	-5900.0
KALRN	-156.0	8062.0
KEL	-5487.0	-227.0
KISS1	-1881.0	1964.0
KISS1R	6453.0	5796.0
KNG1	-8772.0	-8546.0
KPNA2	7880.0	-3492.0
KRAS	5560.0	-6672.0
LDLR	2690.0	-7724.0
LHCGR	237.5	-626.0
LPAR1	3098.0	-5711.0
LPAR2	8068.0	-8338.0
LPAR3	6948.0	-7602.0
LPAR4	6770.0	1338.0
LPAR5	-7773.0	-5264.0
LPAR6	-3764.0	-3332.0
LPL	-2238.0	3473.0
LRAT	-4187.0	-8008.0
LRP1	4525.0	-3430.0
LRP10	-3049.0	1097.0
LRP12	7377.0	6292.0
LRP2	-5280.0	-5955.0
LRP8	1858.0	2029.0
LTB4R	-1961.0	234.0
LTB4R2	6674.0	5146.0
MAPK1	1821.0	-516.0
MAPK3	2277.0	2915.0
MAPK7	4442.0	-7552.0
MC2R	1930.0	-5097.0
MC3R	181.5	-670.5
MC4R	7971.0	3408.0
MC5R	-4127.0	7840.0
MCF2	-7412.0	-531.0
MCF2L	-7244.0	7750.0
MCHR1	-3636.0	-56.0
METAP1	-1313.0	-3522.0
METAP2	4889.0	3851.0
MGLL	-7308.0	-7146.0
MMP3	7257.0	-6705.0
MTNR1A	-867.5	810.5
MYO7A	3391.0	5614.0
NAPEPLD	5936.0	8482.0
NET1	-4723.0	-1696.0
NGEF	-4590.0	-3655.0
NLN	778.0	-1384.0
NMB	3423.0	-4402.0
NMBR	5233.0	792.0
NMT1	296.0	7716.0
NMT2	-3812.0	-760.0
NMU	4241.0	-5547.0
NMUR1	-4753.0	-5489.0
NMUR2	6855.0	-1499.0
NPB	-3566.0	3911.0
NPFF	-1812.0	2875.0
NPFFR1	-7609.0	3959.0
NPSR1	-1277.0	-4562.0
NPW	-4490.0	-955.0
NPY	-7775.0	3479.0
NPY1R	-7739.0	-1346.0
NPY4R	334.5	-1403.5
NRAS	1555.0	-7507.0
NTS	-7592.0	2138.0
NTSR1	-8450.0	2496.0
NTSR2	7875.0	-6085.0
OBSCN	-8298.0	-460.0
OPN1LW	-1861.0	-2180.0
OPN1MW	-1861.0	-2180.0
OPN1SW	7823.0	996.0
OPN3	8120.0	3804.0
OPN4	435.0	4831.0
OPN5	756.0	-626.0
OPRD1	-166.0	-966.0
OPRK1	6564.0	85.0
OPRL1	-664.0	142.0
OPRM1	8454.0	8879.0
OR10G2	-1991.0	1560.5
OR10G3	-275.0	-4884.0
OR10H1	908.5	-3428.5
OR10H5	908.5	-3428.5
OR10K1	-1607.0	-2675.0
OR10V1	-1377.0	-1620.0
OR11A1	-1614.0	-2180.0
OR13J1	181.5	-2913.0
OR14J1	-1377.0	-1499.0
OR1F1	5487.0	-2601.0
OR1I1	-1377.0	1579.0
OR1J1	181.5	-1499.0
OR1N1	-117.0	-1065.0
OR1Q1	-1377.0	6549.0
OR2A1	-867.5	899.5
OR2A14	181.5	945.0
OR2AG1	571.0	-3811.0
OR2AG2	1207.5	2759.0
OR2AT4	1992.0	7054.0
OR2B11	-827.0	-2156.0
OR2B2	311.0	3474.0
OR2F1	-1637.5	-3555.5
OR2F2	-1637.5	-3555.5
OR2H1	-827.0	4363.5
OR2H2	-827.0	4363.5
OR2K2	6156.0	-4261.0
OR2T29	-819.0	-7413.0
OR2T4	-819.0	-7413.0
OR2T5	-819.0	-7413.0
OR2V1	742.0	6773.0
OR2V2	754.0	-5294.0
OR2Y1	181.5	-729.0
OR2Z1	754.0	810.5
OR4B1	-1195.0	-670.5
OR4C6	-867.5	-6574.0
OR4E1	6227.0	-2368.0
OR4F6	-275.0	838.5
OR4M1	721.5	810.5
OR4M2	721.5	810.5
OR4N5	1317.0	838.5
OR51D1	4416.0	3915.0
OR51E1	-6575.0	-2247.0
OR51E2	-3024.0	-6889.0
OR51F1	181.5	838.5
OR52B2	-3568.0	2219.0
OR52E6	710.0	-670.5
OR52E8	710.0	-670.5
OR52I1	-5765.5	-3985.5
OR52I2	-5765.5	-3985.5
OR52L1	181.5	1634.0
OR52N2	-666.5	-1416.0
OR52W1	-7604.0	5475.0
OR56B4	-1377.0	7096.0
OR5AK2	-1355.0	-3677.5
OR5AK3P	-1355.0	-3677.5
OR5C1	242.0	-4343.0
OR5G3	-1548.5	-3387.0
OR5H1	-461.0	1640.5
OR5H14	-461.0	1640.5
OR5H15	-461.0	1640.5
OR5H6	-461.0	1640.5
OR5P2	-1796.0	7457.0
OR6B2	6.5	-2180.0
OR6B3	6.5	-2180.0
OR6C70	2066.0	5361.0
OR6K2	5000.0	3603.0
OR6K3	1810.0	-5308.0
OR6K6	-5066.0	-2008.0
OR6N1	5975.0	-5447.0
OR6N2	-4873.0	-6751.0
OR6S1	-5701.0	614.0
OR6X1	181.5	-1499.0
OR7E24	-1849.0	-1419.0
OR7G1	-867.5	-5697.0
OR7G2	-666.5	110.0
OR8G1	-2149.5	208.5
OR8G5	-2149.5	208.5
OR9A4	-275.0	2248.0
OR9K2	-867.5	944.0
OXT	337.0	5592.0
OXTR	4992.0	-1145.0
P2RY1	6656.0	4049.0
P2RY10	-4675.0	3120.0
P2RY12	2088.0	-5749.0
P2RY13	7352.0	1973.0
P2RY14	-8397.0	-4441.0
P2RY2	-2186.0	-5109.0
P2RY4	3220.0	-3917.0
P2RY6	-5372.0	6897.0
PAK1	-8756.0	-7874.0
PCP2	-5732.0	7613.0
PDE10A	5206.0	-3074.0
PDE11A	-8566.0	1978.0
PDE1A	3081.0	-5361.0
PDE1B	-8152.0	-5932.0
PDE1C	-7328.0	-8536.0
PDE2A	-8637.0	-1170.0
PDE3A	3521.0	-2301.0
PDE3B	1441.0	-6631.0
PDE4A	-4371.0	3271.0
PDE4B	6975.0	7351.0
PDE4C	-7717.5	2744.5
PDE4D	-8678.0	-1667.0
PDE6A	-4282.0	-4130.0
PDE6B	-408.0	-5598.0
PDE6G	7972.0	-6160.0
PDE7A	8556.0	-2532.0
PDE7B	-5141.0	4089.0
PDE8A	3902.0	5039.0
PDE8B	2768.5	-6469.5
PDPK1	-4064.0	4848.0
PDYN	2874.0	2632.0
PENK	-2046.0	6173.0
PIK3CA	82.0	-3696.0
PIK3CG	6551.0	-4399.0
PIK3R1	7815.0	4899.0
PIK3R2	-6826.5	1491.5
PIK3R3	470.5	349.5
PIK3R5	-5218.0	-5522.0
PIK3R6	-5980.0	-2943.0
PLA2G4A	8255.0	-2638.0
PLB1	-8120.0	7640.0
PLCB1	-3795.0	4753.0
PLCB2	6897.0	-6276.0
PLCB3	-7682.0	3196.0
PLCB4	-8101.0	8738.0
PLEKHG2	-6933.0	-8004.0
PLEKHG5	-8179.0	3086.0
PLPPR1	-8115.0	7245.0
PLPPR2	4091.0	3657.0
PLPPR3	-8529.0	8082.0
PLPPR4	4454.0	4131.0
PLPPR5	-1665.0	1483.0
PLXNB1	-1136.0	3245.0
PMCH	5599.0	572.0
PNLIP	1669.0	838.5
PNOC	7643.0	-5531.0
POMC	2992.0	4075.0
PPBP	-2248.0	-3369.0
PPEF1	557.0	5141.0
PPP1CA	-5613.0	8001.0
PPP1R1B	3579.0	7098.0
PPP2CA	-5989.0	-1036.0
PPP2CB	-3379.0	-1146.0
PPP2R1A	-3227.0	6730.0
PPP2R1B	4232.0	3139.0
PPP2R5D	469.0	5899.0
PPP3CA	-2422.0	-5921.0
PPP3CB	-680.0	1841.0
PPP3CC	-8201.0	7977.0
PPP3R1	4773.5	-1941.5
PREX1	-2801.0	1977.0
PRKACA	-7439.0	7145.0
PRKACB	-6436.0	1450.0
PRKAR1A	-4709.0	5819.0
PRKAR1B	7738.0	1273.0
PRKAR2A	-7831.0	8145.0
PRKAR2B	-8604.0	-8020.0
PRKCA	-1604.0	-4833.0
PRKCB	2372.0	-8162.0
PRKCD	1334.0	5533.0
PRKCE	-6856.0	4958.0
PRKCG	-2544.0	-1021.0
PRKCH	-4886.5	1334.5
PRKCQ	-3233.0	-5957.0
PRKX	5161.5	-4247.5
PRLHR	345.0	-670.5
PROK1	-867.5	2985.0
PROK2	1591.0	4196.5
PROKR2	-3965.0	-940.0
PSAP	-6404.0	5173.0
PTAFR	3950.0	-5186.0
PTCH1	5370.0	7986.0
PTCH2	-4037.0	-5616.0
PTGDR	5730.0	-5459.0
PTGDR2	-5770.0	-3784.0
PTGER1	-4963.0	2824.0
PTGER2	-6605.0	-5802.0
PTGER3	-8647.0	-4662.0
PTGER4	-7272.0	-2067.0
PTGFR	6591.0	6001.0
PTGIR	-3062.0	6837.0
PTH1R	-5288.0	-5177.0
PTH2R	181.5	-1499.0
PYY	721.5	-3217.0
QRFP	910.0	4775.0
QRFPR	-7702.0	-6995.0
RAMP1	-5390.0	2891.0
RAMP2	-5805.0	1740.0
RAMP3	4822.0	866.0
RASGRF2	4935.0	3443.0
RASGRP1	6707.0	2181.0
RASGRP2	-7077.0	5360.0
RBP1	-6704.0	-3493.0
RBP2	-867.5	317.0
RBP3	4574.0	-5707.0
RBP4	-7903.0	-1898.0
RCVRN	-4839.0	-6488.0
RDH10	4715.0	-5980.0
RDH11	8310.5	6795.5
RDH12	6109.0	4333.0
RDH16	-8774.0	5953.0
RDH5	6224.0	-6063.0
RDH8	-5806.0	-1954.0
REEP1	-229.0	6849.0
REEP2	-2035.0	3.0
REEP3	-8.0	-4051.0
REEP4	6172.0	1480.0
REEP5	-190.0	6252.0
REEP6	-5935.0	-2027.0
RETSAT	-542.0	6311.0
RGR	-3217.0	-670.5
RGS1	-1921.0	-7143.0
RGS10	4166.0	-257.0
RGS12	6440.0	-6473.0
RGS13	-1094.0	-6464.0
RGS14	-8300.0	5448.0
RGS16	678.0	-828.0
RGS17	-8496.0	-6323.0
RGS18	-111.0	-17.0
RGS19	5379.0	1419.0
RGS2	-7527.0	-887.0
RGS20	-8241.0	6747.0
RGS21	181.5	-262.0
RGS22	2259.0	-3905.0
RGS3	-4230.0	8458.0
RGS4	-619.0	-2904.0
RGS5	-8254.0	3797.0
RGS6	-8182.0	3016.0
RGS7	3146.0	-3095.0
RGS8	-6769.0	-8429.0
RGS9	4793.0	-2317.0
RGS9BP	4132.0	5276.0
RGSL1	4979.0	1163.0
RHO	-3722.0	-6540.0
RHOA	-580.0	1949.0
RHOB	-2836.0	893.0
RHOC	5220.5	1265.5
RLBP1	-4969.0	-5356.0
RLN2	4043.5	3745.5
RLN3	-1894.0	-3257.0
ROCK1	4677.0	-5373.0
ROCK2	-3144.0	-739.0
RPE65	6781.0	-7627.0
RPS6KA1	-8334.0	3660.0
RPS6KA2	1099.0	3485.0
RPS6KA3	-3445.0	-1615.0
RRH	-8492.0	-8454.0
RTP1	181.5	3669.0
RTP3	-6814.0	-5560.0
RTP4	1917.0	-353.0
RXFP1	-3204.0	3113.0
RXFP2	-7357.0	-1535.0
S1PR1	-6843.0	-1277.0
S1PR2	5338.0	-7215.0
S1PR3	6834.0	565.0
S1PR4	-6316.0	-1887.0
S1PR5	5308.0	-5548.0
SAG	-8731.0	-8503.0
SCT	2176.0	7250.0
SCTR	1745.0	6278.0
SDC1	7023.0	-7120.0
SDC2	6159.0	-6681.0
SDC3	-1826.0	1368.0
SDC4	-2743.0	-3481.0
SDR9C7	3288.0	-7652.0
SHH	2945.0	-670.5
SLC24A1	3754.0	-3497.0
SMO	7723.0	3805.0
SOS1	-2568.0	1190.0
SOS2	7364.0	-8297.0
SRC	-7820.0	-2286.0
SSTR1	-6035.0	107.0
SSTR2	1116.0	3144.0
SSTR3	-3727.0	-5360.0
SSTR4	-4776.0	2241.0
SSTR5	-2559.5	1634.0
STRA6	6219.0	1122.0
SUCNR1	-5514.0	1765.0
TAAR8	181.5	-3625.0
TAC1	571.0	-6331.0
TAC3	-5919.0	-5727.0
TACR1	-5779.0	6250.0
TACR2	-5223.0	3951.0
TACR3	-5705.0	-1735.0
TAS1R1	6519.0	7099.0
TAS1R2	-8764.0	8577.0
TAS1R3	-8475.0	6729.0
TAS2R13	765.0	-6702.0
TAS2R14	-1344.0	1560.5
TAS2R19	425.0	-303.0
TAS2R20	425.0	-303.0
TAS2R3	-3894.0	1843.0
TAS2R30	425.0	-303.0
TAS2R31	425.0	-303.0
TAS2R4	139.0	5573.0
TAS2R41	5854.0	388.0
TAS2R43	425.0	-303.0
TAS2R46	425.0	-303.0
TAS2R50	425.0	-303.0
TAS2R60	-4349.0	-2106.0
TAS2R7	181.5	-1499.0
TBXA2R	2560.0	578.0
TIAM1	6649.0	-6513.0
TIAM2	4557.0	-3250.0
TRH	-8042.0	-8132.0
TRHR	-1239.0	-1139.0
TRIO	-6078.0	-276.0
TRPC3	8412.0	-8522.0
TRPC6	7914.0	-6802.0
TRPC7	4465.0	-4184.0
TSHB	-5052.0	2159.0
TSHR	-6228.0	-6642.0
TTR	-8563.0	-2206.0
UCN	5311.0	-1044.0
UCN2	7739.0	3834.0
UTS2	-3543.0	-6199.0
VAV1	1672.0	-7291.0
VAV2	5524.0	8208.0
VAV3	-6816.0	-7178.0
VIP	-7808.0	-7758.0
VIPR1	-7988.0	-1820.0
VIPR2	6089.0	-2150.0
WNT1	2615.0	3316.0
WNT10A	-6916.0	-2180.0
WNT10B	7583.0	-5435.0
WNT11	7463.0	2369.0
WNT16	-4913.0	554.0
WNT2	6584.0	-6510.0
WNT2B	-5589.0	-6294.0
WNT3	-1275.0	6359.0
WNT3A	-1238.0	-1499.0
WNT4	-8479.0	-8272.0
WNT5A	2219.0	-2452.0
WNT6	-5918.0	-3739.0
WNT7A	-1644.0	-2911.0
WNT7B	-2674.0	-7258.0
WNT8A	-2210.0	-3600.0
WNT8B	-5433.0	-3163.0
WNT9A	-3412.0	-3862.0
WNT9B	8285.0	-7433.0
XCL1	1182.5	-3585.5
XCL2	1182.5	-3585.5
XCR1	-4322.0	-3129.0
XK	-7719.0	4244.0

---

---

Collagen formation

Collagen formation

metric	value
setSize	80
pMANOVA	5.98e-07
p.adjustMANOVA	2.7e-05
s.dist	0.351
s.skel	0.292
s.heart	-0.195
p.skel	6.41e-06
p.heart	0.00262

Top 20 genes

Gene	skel	heart
COL1A2	8646	-8142
LOX	8629	-7835
COL17A1	8431	-7864
LOXL2	8048	-7502
COL9A1	7629	-7596
ADAMTS2	7792	-7360
P4HA3	8121	-6524
COL5A1	6940	-7391
MMP3	7257	-6705
PCOLCE	8040	-5842
COL1A1	7658	-5194
ADAMTS14	4506	-8449
COL16A1	8070	-4660
COL8A1	6875	-5009
LOXL1	6792	-4822
PCOLCE2	6624	-4319
COL11A1	6464	-4136
ADAMTS3	7115	-3699
LOXL4	5722	-4592
BMP1	6942	-3393

Click HERE to show all gene set members

All member genes

	skel	heart
ADAMTS14	4506	-8449
ADAMTS2	7792	-7360
ADAMTS3	7115	-3699
BMP1	6942	-3393
CD151	1511	8770
COL11A1	6464	-4136
COL11A2	8290	7577
COL12A1	7185	-178
COL13A1	8138	-1750
COL14A1	4918	-4721
COL15A1	-5886	-7959
COL16A1	8070	-4660
COL17A1	8431	-7864
COL18A1	-4869	-4416
COL19A1	340	4545
COL1A1	7658	-5194
COL1A2	8646	-8142
COL23A1	2919	241
COL25A1	-8018	-8002
COL26A1	3501	8279
COL27A1	786	4537
COL28A1	-2751	1895
COL2A1	6821	3122
COL3A1	3633	-5649
COL4A1	-4211	-906
COL4A2	-4558	3087
COL4A3	277	-2252
COL4A5	-2815	-3410
COL4A6	3357	3153
COL5A1	6940	-7391
COL5A2	2796	-2318
COL5A3	-795	-6519
COL6A1	3476	-5787
COL6A2	4476	-4395
COL6A5	-5511	-7144
COL6A6	-3515	-6225
COL8A1	6875	-5009
COL8A2	7772	1154
COL9A1	7629	-7596
COL9A2	-7469	-4035
COLGALT1	-822	4399
COLGALT2	-7519	-2425
CRTAP	2651	-6133
CTSB	-1172	2279
CTSS	2144	1663
CTSV	-4285	-863
DST	5620	4619
ITGA6	-5627	-2840
ITGB4	-6582	-3433
LAMA3	-5909	-7742
LAMB3	6131	4835
LAMC2	8618	8786
LOX	8629	-7835
LOXL1	6792	-4822
LOXL2	8048	-7502
LOXL3	-1831	-3276
LOXL4	5722	-4592
MMP13	-688	-4864
MMP20	3641	-24
MMP3	7257	-6705
MMP7	2472	-4770
MMP9	7224	4324
P3H1	1808	-6415
P3H2	5638	2201
P3H3	3608	-2258
P4HA1	5255	6345
P4HA2	8021	8225
P4HA3	8121	-6524
P4HB	-2194	6155
PCOLCE	8040	-5842
PCOLCE2	6624	-4319
PLEC	-8801	8684
PLOD1	511	5968
PLOD2	-7684	6714
PLOD3	4327	2195
PPIB	6594	-1443
PXDN	-7402	-5076
SERPINH1	7945	4411
TLL1	3804	-6022
TLL2	5955	3793

---

---

Regulation of Apoptosis

Regulation of Apoptosis

metric	value
setSize	50
pMANOVA	6.3e-07
p.adjustMANOVA	2.75e-05
s.dist	0.434
s.skel	0.0749
s.heart	0.428
p.skel	0.36
p.heart	1.64e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
OPA1	1993.0	8508.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0
PSMA1	2067.0	1803.0
PSMD14	546.0	6040.0

Click HERE to show all gene set members

All member genes

	skel	heart
ARHGAP10	5377.0	-2918.0
OMA1	-1112.0	5493.0
OPA1	1993.0	8508.0
PAK2	2265.0	441.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RPS27A	7076.0	2193.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0

---

---

AUF1 (hnRNP D0) binds and destabilizes mRNA

AUF1 (hnRNP D0) binds and destabilizes mRNA

metric	value
setSize	51
pMANOVA	7.36e-07
p.adjustMANOVA	3.06e-05
s.dist	0.43
s.skel	-0.00537
s.heart	0.43
p.skel	0.947
p.heart	1.07e-07

Top 20 genes

Gene	skel	heart
EIF4G1	-8382.0	8463.0
PSMB9	-7590.0	6708.0
PSMD11	-8283.0	5672.0
PSMD1	-5118.0	8590.0
HSPA1A	-4698.5	7720.5
PSMA8	-5126.0	6412.0
PSMB7	-5015.0	5872.0
PSMD3	-5302.0	5397.0
PSMC3	-4588.0	4871.0
PSMD7	-3537.0	5839.0
PSMD4	-2843.0	6907.0
PSMC4	-4019.0	4642.0
PSME1	-2771.0	6314.0
PSMB2	-5719.0	2861.0
UBA52	-1940.0	7240.0
PSME3	-8528.0	1402.0
PSMB5	-1735.0	6793.0
PSMD10	-1528.0	4981.0
PSMD8	-967.0	5567.0
HSPB1	-5494.0	670.0

Click HERE to show all gene set members

All member genes

	skel	heart
EIF4G1	-8382.0	8463.0
HNRNPD	-8339.0	-8307.0
HSPA1A	-4698.5	7720.5
HSPA8	382.0	7793.0
HSPB1	-5494.0	670.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RPS27A	7076.0	2193.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0

---

---

Degradation of GLI2 by the proteasome

Degradation of GLI2 by the proteasome

metric	value
setSize	55
pMANOVA	7.42e-07
p.adjustMANOVA	3.06e-05
s.dist	0.413
s.skel	0.0406
s.heart	0.411
p.skel	0.603
p.heart	1.36e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
SUFU	4832.0	5254.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
SKP1	944.0	7264.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0
PSMA1	2067.0	1803.0

Click HERE to show all gene set members

All member genes

	skel	heart
BTRC	5925.0	-1783.0
CSNK1A1	7847.0	-5640.0
CUL1	-2470.0	5696.0
GSK3B	-8272.0	-751.0
PRKACA	-7439.0	7145.0
PRKACB	-6436.0	1450.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RBX1	92.0	4055.0
RPS27A	7076.0	2193.0
SKP1	944.0	7264.0
SUFU	4832.0	5254.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0

---

---

Vpu mediated degradation of CD4

Vpu mediated degradation of CD4

metric	value
setSize	49
pMANOVA	8.63e-07
p.adjustMANOVA	3.46e-05
s.dist	0.434
s.skel	0.0755
s.heart	0.427
p.skel	0.361
p.heart	2.27e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
SKP1	944.0	7264.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0
PSMA1	2067.0	1803.0
PSMD14	546.0	6040.0

Click HERE to show all gene set members

All member genes

	skel	heart
BTRC	5925.0	-1783.0
CD4	1353.0	1902.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RPS27A	7076.0	2193.0
SKP1	944.0	7264.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0

---

---

Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle

metric	value
setSize	52
pMANOVA	1.1e-06
p.adjustMANOVA	4.27e-05
s.dist	0.42
s.skel	-0.0192
s.heart	0.42
p.skel	0.811
p.heart	1.63e-07

Top 20 genes

Gene	skel	heart
PDP1	-7819.0	8521.0
LDHC	-7316.0	7296.0
IDH2	-6791.0	7310.0
PDK2	-5697.0	7102.0
ADHFE1	-4253.0	6327.0
OGDH	-5740.0	4362.0
FH	-2698.0	6352.0
PPARD	-6659.0	2423.0
VDAC1	-3136.0	4155.0
PDHA1	-1572.0	6522.0
PDK1	-2244.0	4071.0
SUCLA2	-2280.0	3175.0
IDH3G	-2889.0	2505.0
SDHA	-1653.5	4126.5
LDHA	-3338.0	1521.0
MDH2	-3909.0	1091.0
LDHB	-415.5	7317.5
D2HGDH	-5292.0	520.0
RXRA	-4958.0	387.0
SDHD	-257.5	2208.5

Click HERE to show all gene set members

All member genes

	skel	heart
ACO2	769.0	8700.0
ADHFE1	-4253.0	6327.0
BSG	6138.0	8069.0
CS	1762.0	5778.0
D2HGDH	-5292.0	520.0
DLAT	6055.0	6731.0
DLD	3620.0	2901.0
DLST	2103.0	7989.0
FAHD1	6514.0	7880.0
FH	-2698.0	6352.0
GLO1	1342.0	1240.0
GSTZ1	-8419.0	-7748.0
HAGH	3972.0	6673.0
IDH2	-6791.0	7310.0
IDH3A	-64.0	7065.0
IDH3B	434.0	6615.0
IDH3G	-2889.0	2505.0
L2HGDH	4426.0	4326.0
LDHA	-3338.0	1521.0
LDHB	-415.5	7317.5
LDHC	-7316.0	7296.0
MDH2	-3909.0	1091.0
ME1	591.0	-80.0
ME2	2166.0	9.0
ME3	4563.0	7888.0
MPC1	7100.0	5720.0
MPC2	5072.0	4734.0
NNT	-231.0	772.0
OGDH	-5740.0	4362.0
PDHA1	-1572.0	6522.0
PDHB	4035.0	8121.0
PDHX	6673.0	8447.0
PDK1	-2244.0	4071.0
PDK2	-5697.0	7102.0
PDK3	-21.0	-6639.0
PDK4	-5726.0	-493.0
PDP1	-7819.0	8521.0
PDP2	3218.0	2237.0
PDPR	3181.0	6000.0
PPARD	-6659.0	2423.0
RXRA	-4958.0	387.0
SDHA	-1653.5	4126.5
SDHB	1308.0	6790.0
SDHC	1049.0	4498.0
SDHD	-257.5	2208.5
SLC16A1	1474.0	-367.0
SLC16A3	2487.0	-369.0
SLC16A8	1819.0	-5156.0
SUCLA2	-2280.0	3175.0
SUCLG1	4086.0	3231.0
SUCLG2	-4818.0	-229.0
VDAC1	-3136.0	4155.0

---

---

Collagen biosynthesis and modifying enzymes

Collagen biosynthesis and modifying enzymes

metric	value
setSize	58
pMANOVA	1.13e-06
p.adjustMANOVA	4.27e-05
s.dist	0.403
s.skel	0.337
s.heart	-0.221
p.skel	9.22e-06
p.heart	0.00366

Top 20 genes

Gene	skel	heart
COL1A2	8646	-8142
COL17A1	8431	-7864
COL9A1	7629	-7596
ADAMTS2	7792	-7360
P4HA3	8121	-6524
COL5A1	6940	-7391
PCOLCE	8040	-5842
COL1A1	7658	-5194
ADAMTS14	4506	-8449
COL16A1	8070	-4660
COL8A1	6875	-5009
PCOLCE2	6624	-4319
COL11A1	6464	-4136
ADAMTS3	7115	-3699
BMP1	6942	-3393
COL14A1	4918	-4721
TLL1	3804	-6022
COL3A1	3633	-5649
COL6A1	3476	-5787
COL6A2	4476	-4395

Click HERE to show all gene set members

All member genes

	skel	heart
ADAMTS14	4506	-8449
ADAMTS2	7792	-7360
ADAMTS3	7115	-3699
BMP1	6942	-3393
COL11A1	6464	-4136
COL11A2	8290	7577
COL12A1	7185	-178
COL13A1	8138	-1750
COL14A1	4918	-4721
COL15A1	-5886	-7959
COL16A1	8070	-4660
COL17A1	8431	-7864
COL18A1	-4869	-4416
COL19A1	340	4545
COL1A1	7658	-5194
COL1A2	8646	-8142
COL23A1	2919	241
COL25A1	-8018	-8002
COL26A1	3501	8279
COL27A1	786	4537
COL28A1	-2751	1895
COL2A1	6821	3122
COL3A1	3633	-5649
COL4A1	-4211	-906
COL4A2	-4558	3087
COL4A3	277	-2252
COL4A5	-2815	-3410
COL4A6	3357	3153
COL5A1	6940	-7391
COL5A2	2796	-2318
COL5A3	-795	-6519
COL6A1	3476	-5787
COL6A2	4476	-4395
COL6A5	-5511	-7144
COL6A6	-3515	-6225
COL8A1	6875	-5009
COL8A2	7772	1154
COL9A1	7629	-7596
COL9A2	-7469	-4035
COLGALT1	-822	4399
COLGALT2	-7519	-2425
CRTAP	2651	-6133
P3H1	1808	-6415
P3H2	5638	2201
P3H3	3608	-2258
P4HA1	5255	6345
P4HA2	8021	8225
P4HA3	8121	-6524
P4HB	-2194	6155
PCOLCE	8040	-5842
PCOLCE2	6624	-4319
PLOD1	511	5968
PLOD2	-7684	6714
PLOD3	4327	2195
PPIB	6594	-1443
SERPINH1	7945	4411
TLL1	3804	-6022
TLL2	5955	3793

---

---

Vif-mediated degradation of APOBEC3G

Vif-mediated degradation of APOBEC3G

metric	value
setSize	50
pMANOVA	1.27e-06
p.adjustMANOVA	4.7e-05
s.dist	0.425
s.skel	0.0348
s.heart	0.423
p.skel	0.671
p.heart	2.23e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0
PSMA1	2067.0	1803.0
PSMD14	546.0	6040.0
PSMB4	1768.0	1526.0

Click HERE to show all gene set members

All member genes

	skel	heart
CUL5	-2111.0	4589.0
ELOB	-275.0	-4953.0
ELOC	-6650.0	5809.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RBX1	92.0	4055.0
RPS27A	7076.0	2193.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0

---

---

Mitochondrial Fatty Acid Beta-Oxidation

Mitochondrial Fatty Acid Beta-Oxidation

metric	value
setSize	36
pMANOVA	1.33e-06
p.adjustMANOVA	4.73e-05
s.dist	0.5
s.skel	0.0165
s.heart	0.5
p.skel	0.864
p.heart	2.08e-07

Top 20 genes

Gene	skel	heart
DBI	8491.0	7771.0
ACADS	3790.0	7879.0
NDUFAB1	6473.0	4242.0
MECR	3720.0	7287.0
ACBD6	3601.0	7320.0
MCEE	3371.0	5115.0
ACOT13	3860.0	3992.0
ACADVL	2074.0	6681.0
ACOT1	2480.5	5274.5
ACOT2	2480.5	5274.5
THEM4	6362.0	1815.0
MMUT	3007.0	3582.0
PCCA	1291.0	8102.0
ACSM3	4133.0	1985.0
ACOT9	3440.0	1629.0
ECI1	574.0	7523.0
THEM5	1091.0	3204.0

Click HERE to show all gene set members

All member genes

	skel	heart
ACAA2	-755.0	8275.0
ACAD10	-6953.0	4446.0
ACAD11	-6861.0	4176.0
ACADL	-569.0	4303.0
ACADM	-1240.0	6598.0
ACADS	3790.0	7879.0
ACADVL	2074.0	6681.0
ACBD6	3601.0	7320.0
ACBD7	-1414.0	4844.0
ACOT1	2480.5	5274.5
ACOT11	-1586.0	5683.0
ACOT12	-2653.0	-3316.0
ACOT13	3860.0	3992.0
ACOT2	2480.5	5274.5
ACOT7	-1142.0	5543.0
ACOT9	3440.0	1629.0
ACSF2	-7301.0	3820.0
ACSM3	4133.0	1985.0
DBI	8491.0	7771.0
DECR1	-3353.0	-1646.0
ECHS1	-2892.0	7032.0
ECI1	574.0	7523.0
HADH	-1542.0	5840.0
HADHA	-1441.0	5164.0
HADHB	-2312.0	6232.0
MCAT	-3761.0	6049.0
MCEE	3371.0	5115.0
MECR	3720.0	7287.0
MMAA	-3997.0	2983.0
MMUT	3007.0	3582.0
NDUFAB1	6473.0	4242.0
PCCA	1291.0	8102.0
PCCB	-7145.0	2979.0
PCTP	-599.0	-4906.0
THEM4	6362.0	1815.0
THEM5	1091.0	3204.0

---

---

Degradation of GLI1 by the proteasome

Degradation of GLI1 by the proteasome

metric	value
setSize	56
pMANOVA	1.34e-06
p.adjustMANOVA	4.73e-05
s.dist	0.401
s.skel	0.0243
s.heart	0.4
p.skel	0.753
p.heart	2.23e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
SUFU	4832.0	5254.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
SKP1	944.0	7264.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0
PSMA1	2067.0	1803.0

Click HERE to show all gene set members

All member genes

	skel	heart
BTRC	5925.0	-1783.0
CUL1	-2470.0	5696.0
GLI1	903.0	610.0
ITCH	-750.0	-551.0
NUMB	-8219.0	-7933.0
PRKACA	-7439.0	7145.0
PRKACB	-6436.0	1450.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RBX1	92.0	4055.0
RPS27A	7076.0	2193.0
SKP1	944.0	7264.0
SUFU	4832.0	5254.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0

---

---

Interleukin-1 family signaling

Interleukin-1 family signaling

metric	value
setSize	127
pMANOVA	1.38e-06
p.adjustMANOVA	4.74e-05
s.dist	0.265
s.skel	0.0546
s.heart	0.26
p.skel	0.288
p.heart	4.37e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
APP	7187.0	7687.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
IL36RN	5982.0	6500.0
PSMA6	5158.0	7228.0
PTPN18	6303.0	5849.0
PTPN6	4387.0	8129.0
NKIRAS1	4837.0	7236.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PTPN11	3428.0	7796.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
IL1B	3746.0	6531.0
PSMA7	5019.0	3863.0
CASP1	4178.0	4456.0
IL33	5523.0	3011.0
PSME2	6732.0	2469.0

Click HERE to show all gene set members

All member genes

	skel	heart
AGER	-8777.0	8839.0
ALOX5	2483.0	-4648.0
APP	7187.0	7687.0
BTRC	5925.0	-1783.0
CASP1	4178.0	4456.0
CHUK	6014.0	-2315.0
CUL1	-2470.0	5696.0
FBXW11	-7722.0	-1164.0
HMGB1	3450.0	-2498.0
IKBKB	3761.0	1108.0
IKBKG	2865.0	5671.0
IL13	721.5	4540.0
IL18	1674.0	-5854.0
IL18BP	1928.0	7621.0
IL18R1	-1322.0	3846.0
IL18RAP	3321.0	576.0
IL1A	-5462.0	-7271.0
IL1B	3746.0	6531.0
IL1F10	1824.0	1676.0
IL1R1	-8096.0	-6934.0
IL1R2	5989.0	1041.0
IL1RAP	2258.0	5334.0
IL1RAPL1	2880.0	-4357.0
IL1RL1	-1520.0	-7824.0
IL1RL2	6521.0	-2309.0
IL1RN	1463.0	660.0
IL33	5523.0	3011.0
IL36A	-867.5	-1499.0
IL36B	280.0	-3850.0
IL36RN	5982.0	6500.0
IL4	573.0	8214.0
IRAK1	660.0	400.0
IRAK2	4643.0	2844.0
IRAK3	83.0	-5545.0
IRAK4	-5745.0	-6244.0
MAP2K1	-4947.0	5163.0
MAP2K4	4302.0	-1337.0
MAP2K6	-1023.0	3781.0
MAP3K3	3408.0	2457.0
MAP3K7	2561.0	-3604.0
MAP3K8	-2030.0	6213.0
MAPK8	5666.0	-565.0
MYD88	-3161.0	1296.0
NFKB1	-2346.0	2317.0
NFKB2	-1871.0	5814.0
NFKBIB	-2048.0	8312.0
NKIRAS1	4837.0	7236.0
NKIRAS2	-2754.0	7826.0
NOD1	-182.0	7988.0
NOD2	-8346.0	-3204.0
PELI1	4988.0	-6089.0
PELI2	1556.0	-4183.0
PELI3	-4236.0	6583.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
PTPN11	3428.0	7796.0
PTPN12	6334.0	-7562.0
PTPN13	7466.0	1045.0
PTPN14	-6913.0	6087.0
PTPN18	6303.0	5849.0
PTPN2	3585.0	-1018.0
PTPN23	-6335.0	-1668.0
PTPN4	-1406.0	-6245.0
PTPN5	647.0	4931.0
PTPN6	4387.0	8129.0
PTPN7	-3442.0	-5512.0
PTPN9	8257.0	-1703.0
RBX1	92.0	4055.0
RELA	-1883.0	-6107.0
RIPK2	-3840.0	-1651.0
RPS27A	7076.0	2193.0
SIGIRR	515.0	-2322.0
SKP1	944.0	7264.0
SMAD3	-28.0	-3448.0
SQSTM1	-5057.0	8580.0
STAT3	-7099.0	5958.0
TAB1	-5854.0	3142.0
TAB2	-1317.0	6676.0
TAB3	1454.0	5326.0
TBK1	-1916.0	6097.0
TNIP2	-2878.0	7130.0
TOLLIP	-4874.0	1269.0
TRAF6	-1959.0	-329.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
UBE2N	3842.5	3787.5

---

---

Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation

metric	value
setSize	47
pMANOVA	1.55e-06
p.adjustMANOVA	5.19e-05
s.dist	0.434
s.skel	0.0638
s.heart	0.429
p.skel	0.449
p.heart	3.53e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0
PSMA1	2067.0	1803.0
PSMD14	546.0	6040.0
PSMB4	1768.0	1526.0

Click HERE to show all gene set members

All member genes

	skel	heart
PAK2	2265.0	441.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RPS27A	7076.0	2193.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0

---

---

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

metric	value
setSize	52
pMANOVA	1.61e-06
p.adjustMANOVA	5.29e-05
s.dist	0.413
s.skel	0.0405
s.heart	0.411
p.skel	0.613
p.heart	3.01e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
SKP1	944.0	7264.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0
PSMA1	2067.0	1803.0
PSMD14	546.0	6040.0

Click HERE to show all gene set members

All member genes

	skel	heart
AURKA	-4639.0	-943.0
CUL1	-2470.0	5696.0
FBXL18	-1763.0	-1324.0
FBXL7	1971.0	-3306.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RBX1	92.0	4055.0
RPS27A	7076.0	2193.0
SKP1	944.0	7264.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0

---

---

Cell surface interactions at the vascular wall

Cell surface interactions at the vascular wall

metric	value
setSize	152
pMANOVA	1.83e-06
p.adjustMANOVA	5.85e-05
s.dist	0.24
s.skel	-0.0376
s.heart	-0.238
p.skel	0.424
p.heart	4.38e-07

Top 20 genes

Gene	skel	heart
L1CAM	-7958.0	-8095.0
ITGAM	-8742.0	-7311.0
CD244	-7289.0	-8350.0
MAG	-5590.0	-7274.0
CEACAM1	-4145.5	-8052.5
CEACAM3	-4145.5	-8052.5
CEACAM5	-4145.5	-8052.5
CEACAM6	-4145.5	-8052.5
CEACAM8	-4145.5	-8052.5
PSG1	-4145.5	-8052.5
PSG11	-4145.5	-8052.5
PSG2	-4145.5	-8052.5
PSG3	-4145.5	-8052.5
PSG4	-4145.5	-8052.5
PSG5	-4145.5	-8052.5
PSG6	-4145.5	-8052.5
PSG7	-4145.5	-8052.5
PSG8	-4145.5	-8052.5
PSG9	-4145.5	-8052.5
ANGPT2	-8002.0	-3216.0

Click HERE to show all gene set members

All member genes

	skel	heart
ANGPT1	-3971.0	2925.0
ANGPT2	-8002.0	-3216.0
ANGPT4	3388.0	2057.0
APOB	446.0	-8252.0
ATP1B1	-1025.0	8732.0
ATP1B2	2692.0	-6193.0
ATP1B3	491.0	-2949.0
BSG	6138.0	8069.0
CAV1	-1519.0	-5639.0
CD177	-2737.0	-604.0
CD2	116.0	-5279.0
CD244	-7289.0	-8350.0
CD44	5992.0	-7861.0
CD47	7645.0	-7542.0
CD48	1825.0	-4275.0
CD74	-7837.0	8570.0
CD84	-7910.0	2268.0
CD99	8327.0	4188.0
CD99L2	7989.0	-7939.0
CEACAM1	-4145.5	-8052.5
CEACAM3	-4145.5	-8052.5
CEACAM5	-4145.5	-8052.5
CEACAM6	-4145.5	-8052.5
CEACAM8	-4145.5	-8052.5
CXADR	1054.0	-6028.0
DOK2	1229.0	-3385.0
EPCAM	2951.0	-849.0
ESAM	-1948.0	5488.0
F11R	-3656.0	-512.0
F2	-3364.0	634.0
FCAMR	5786.0	-3775.0
FCER1G	3504.0	1756.0
FN1	6620.0	-6064.0
FYN	8359.0	-337.0
GAS6	2959.0	8889.0
GLG1	-3671.0	-2500.0
GP6	-3631.0	896.0
GPC1	3367.0	6196.0
GRB14	3290.0	6434.0
GRB2	-3087.0	5476.0
GRB7	4443.0	-5502.0
GYPC	-5821.0	-2682.0
HRAS	-2027.0	8503.0
IGHM	-8802.0	7766.0
IGHV2-5	3294.0	-2767.0
IGHV2-70	3294.0	-2767.0
IGHV4-34	-2578.5	-4293.5
IGHV4-39	-2578.5	-4293.5
IGHV4-59	-2578.5	-4293.5
IGHV7-81	265.5	-670.5
IGKC	-8766.0	8740.0
IGKV1-12	3171.5	-6924.5
IGKV1-16	3171.5	-6924.5
IGKV1-17	3171.5	-6924.5
IGKV1-39	3171.5	-6924.5
IGKV1-5	3171.5	-6924.5
IGKV1D-12	3171.5	-6924.5
IGKV1D-16	3171.5	-6924.5
IGKV1D-39	3171.5	-6924.5
IGKV2-30	3077.5	6166.5
IGKV2D-30	3077.5	6166.5
IGKV4-1	5163.0	354.0
IGLC1	-4933.5	-4735.5
IGLC2	-4933.5	-4735.5
IGLC3	-4933.5	-4735.5
IGLC7	-4933.5	-4735.5
IGLL1	-4933.5	-4735.5
IGLV3-16	2496.0	-5564.0
IGLV3-22	2496.0	-5564.0
IGLV3-25	2496.0	-5564.0
IGLV3-27	2496.0	-5564.0
IGLV6-57	825.0	6813.0
INPP5D	-2917.0	-577.0
ITGA3	-6581.0	8039.0
ITGA4	-4036.0	-1867.0
ITGA5	-7482.0	4873.0
ITGA6	-5627.0	-2840.0
ITGAL	-1557.0	5284.0
ITGAM	-8742.0	-7311.0
ITGAV	1994.0	5984.0
ITGAX	-4974.0	-4134.0
ITGB1	2215.0	5645.0
ITGB2	-404.0	138.0
ITGB3	-3130.5	-3851.5
JAM2	-1732.0	4605.0
JAM3	-2893.0	1355.0
JCHAIN	1081.0	-4257.0
KRAS	5560.0	-6672.0
L1CAM	-7958.0	-8095.0
LCK	-3134.0	-2663.0
LYN	-2472.0	-3441.0
MAG	-5590.0	-7274.0
MERTK	4196.0	-3660.0
MIF	-3295.0	-2145.0
NRAS	1555.0	-7507.0
OLR1	-2003.0	3249.0
PICK1	-5950.0	-1078.0
PIK3CA	82.0	-3696.0
PIK3CB	181.5	-4179.0
PIK3R1	7815.0	4899.0
PIK3R2	-6826.5	1491.5
PLCG1	-4979.0	-3013.0
PPIA	8544.5	-8242.5
PPIL2	1594.0	5753.0
PROC	-3705.0	-1136.0
PROCR	7050.0	-4017.0
PROS1	4415.0	-5354.0
PSG1	-4145.5	-8052.5
PSG11	-4145.5	-8052.5
PSG2	-4145.5	-8052.5
PSG3	-4145.5	-8052.5
PSG4	-4145.5	-8052.5
PSG5	-4145.5	-8052.5
PSG6	-4145.5	-8052.5
PSG7	-4145.5	-8052.5
PSG8	-4145.5	-8052.5
PSG9	-4145.5	-8052.5
PTPN11	3428.0	7796.0
PTPN6	4387.0	8129.0
SDC1	7023.0	-7120.0
SDC2	6159.0	-6681.0
SDC3	-1826.0	1368.0
SDC4	-2743.0	-3481.0
SELE	-1012.0	334.0
SELL	-333.0	4648.0
SELP	-7282.0	-1623.0
SELPLG	-1960.0	1821.0
SHC1	7350.0	-969.0
SIRPA	2317.5	6572.5
SIRPG	2317.5	6572.5
SLC16A1	1474.0	-367.0
SLC16A3	2487.0	-369.0
SLC16A8	1819.0	-5156.0
SLC3A2	-4114.0	-1351.0
SLC7A10	-7233.0	5833.0
SLC7A11	2180.0	-3073.0
SLC7A5	-3004.0	-3076.0
SLC7A6	5889.0	361.0
SLC7A7	4689.0	-6851.0
SLC7A8	-1851.0	-1919.0
SLC7A9	-1252.0	2713.0
SOS1	-2568.0	1190.0
SPN	-2887.0	-5002.0
SRC	-7820.0	-2286.0
TEK	-1088.0	-2357.0
TGFB1	-1002.0	-1450.0
THBD	2744.0	5973.0
TREM1	1962.0	-4314.0
TSPAN7	589.5	5177.5
VPREB1	7374.0	-3686.0
VPREB3	4054.0	-8017.0
YES1	6198.0	-7587.0

---

---

Regulation of RUNX2 expression and activity

Regulation of RUNX2 expression and activity

metric	value
setSize	69
pMANOVA	1.89e-06
p.adjustMANOVA	5.85e-05
s.dist	0.355
s.skel	0.0836
s.heart	0.345
p.skel	0.23
p.heart	7.24e-07

Top 20 genes

Gene	skel	heart
STAT1	8364.0	8774.0
ESRRA	7860.0	8595.0
PSMB8	7349.0	8633.0
ESR1	8600.0	6696.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
TWIST1	5770.0	3981.0
PSMA7	5019.0	3863.0
STUB1	3935.0	4892.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
BMP2	6019.0	2449.0
PSME4	2756.0	5110.0
DLX6	5145.0	2577.0

Click HERE to show all gene set members

All member genes

	skel	heart
BMP2	6019.0	2449.0
CBFB	3374.0	-4409.0
CUL1	-2470.0	5696.0
DLX5	4341.0	-96.0
DLX6	5145.0	2577.0
ESR1	8600.0	6696.0
ESRRA	7860.0	8595.0
FBXW7	-3943.0	-3560.0
GSK3B	-8272.0	-751.0
HIVEP3	-3324.0	-6957.0
MSX2	594.0	-1692.0
NR3C1	-7729.0	5212.0
PPARGC1A	2820.0	1081.0
PPARGC1B	-8304.0	7543.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RBX1	92.0	4055.0
RPS27A	7076.0	2193.0
RUNX2	6427.0	-5755.0
SKP1	944.0	7264.0
SKP2	-5129.0	-4161.0
SMURF1	6097.0	-3765.0
STAT1	8364.0	8774.0
STUB1	3935.0	4892.0
TWIST1	5770.0	3981.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
WWP1	-6428.0	-2328.0

---

---

Complex I biogenesis

Complex I biogenesis

metric	value
setSize	53
pMANOVA	1.91e-06
p.adjustMANOVA	5.85e-05
s.dist	0.403
s.skel	0.191
s.heart	0.355
p.skel	0.0164
p.heart	8.01e-06

Top 20 genes

Gene	skel	heart
ACAD9	7631.0	7946.0
NDUFA8	5987.0	8490.0
NDUFA2	7987.0	5613.0
NDUFA6	5924.0	5771.0
TIMMDC1	4421.0	7069.0
NDUFAB1	6473.0	4242.0
NDUFB9	4566.0	5421.0
NDUFA7	5691.5	3873.5
NDUFAF7	7863.0	2760.0
NDUFV2	3291.0	6011.0
NDUFC1	6283.0	3026.0
NDUFS8	2854.0	5403.0
NDUFS3	2309.0	6202.0
NDUFA12	1609.0	8560.0
NDUFB8	2773.5	4506.5
NDUFB6	3414.0	3235.0
NDUFS4	4055.0	2334.0
NDUFA3	2870.0	2229.0
NDUFA9	1104.0	3610.0
NDUFB5	3542.0	1027.0

Click HERE to show all gene set members

All member genes

	skel	heart
ACAD9	7631.0	7946.0
ECSIT	-2263.0	8037.0
MT-ND1	-3770.0	2451.0
MT-ND2	-783.0	299.0
MT-ND3	-3514.0	1797.0
MT-ND4	-3963.0	382.0
MT-ND5	-4600.0	1285.0
MT-ND6	-4778.0	-754.0
NDUFA1	7797.0	-3580.0
NDUFA10	-377.0	5987.0
NDUFA11	662.5	4964.5
NDUFA12	1609.0	8560.0
NDUFA13	-81.0	7199.0
NDUFA2	7987.0	5613.0
NDUFA3	2870.0	2229.0
NDUFA5	676.0	3420.0
NDUFA6	5924.0	5771.0
NDUFA7	5691.5	3873.5
NDUFA8	5987.0	8490.0
NDUFA9	1104.0	3610.0
NDUFAB1	6473.0	4242.0
NDUFAF1	-2181.0	2883.0
NDUFAF3	-2409.0	6988.0
NDUFAF4	125.0	6668.0
NDUFAF5	-2715.0	1947.0
NDUFAF6	-2930.0	-2683.0
NDUFAF7	7863.0	2760.0
NDUFB10	-1877.0	6302.0
NDUFB11	7357.0	-361.0
NDUFB2	-2642.0	4479.0
NDUFB3	7684.0	-3453.0
NDUFB4	-7278.0	-3860.0
NDUFB5	3542.0	1027.0
NDUFB6	3414.0	3235.0
NDUFB7	-2445.0	2370.0
NDUFB8	2773.5	4506.5
NDUFB9	4566.0	5421.0
NDUFC1	6283.0	3026.0
NDUFC2	781.5	2587.5
NDUFS1	119.0	2981.0
NDUFS2	-1004.0	6854.0
NDUFS3	2309.0	6202.0
NDUFS4	4055.0	2334.0
NDUFS5	-2600.0	8309.0
NDUFS6	7811.0	-2761.0
NDUFS7	-2856.0	7757.0
NDUFS8	2854.0	5403.0
NDUFV1	-133.0	6803.0
NDUFV2	3291.0	6011.0
NDUFV3	8473.0	-6717.0
NUBPL	4558.0	-1135.0
TIMMDC1	4421.0	7069.0
TMEM126B	2822.0	-2468.0

---

---

Deubiquitination

Deubiquitination

metric	value
setSize	231
pMANOVA	2.07e-06
p.adjustMANOVA	6.22e-05
s.dist	0.196
s.skel	-0.0278
s.heart	0.194
p.skel	0.467
p.heart	3.71e-07

Top 20 genes

Gene	skel	heart
FOXO4	-8609	8547
RAD23A	-8502	8501
TNIP1	-8487	8375
USP2	-8157	8661
USP20	-8006	8644
NFRKB	-8253	8027
USP4	-7997	8271
RUVBL1	-7628	8138
USP30	-7166	7213
PSMB9	-7590	6708
UIMC1	-6823	7232
PSMD11	-8283	5672
MDM2	-7130	6576
TNFAIP3	-7045	6507
MYC	-7858	5713
PSMD1	-5118	8590
USP19	-5888	7462
USP12	-8193	5313
HGS	-5517	7748
INO80E	-5894	7220

Click HERE to show all gene set members

All member genes

	skel	heart
ACTB	-5345.0	-7961.0
ACTL6A	7067.0	-1151.0
ACTR5	5736.0	-1883.0
ACTR8	-1958.0	7884.0
ADRB2	2580.0	-3113.0
ADRM1	-1093.0	4794.0
APC	2379.0	4185.0
AR	3529.0	-1894.0
ARRB1	-23.0	757.0
ARRB2	-6483.0	-1323.0
ASXL1	1897.0	-4098.0
ASXL2	-217.0	-950.0
ATXN3	3992.5	5841.5
ATXN3L	3992.5	5841.5
ATXN7	-3828.0	-148.0
AXIN2	-7250.0	3971.0
BABAM1	-4096.0	3462.0
BAP1	-5776.0	6454.0
BARD1	4647.0	376.0
BECN1	-5333.0	-7409.0
BIRC2	-5080.0	231.0
BIRC3	7622.0	-7584.0
BRCA1	6848.0	-6073.0
BRCC3	2462.0	-2304.0
CCNA1	4273.0	-7006.0
CCNA2	-6375.0	-7393.0
CCP110	5409.0	-192.0
CDC20	-7220.0	-8234.0
CDC25A	-457.0	-1553.0
CDK1	-7804.0	-8477.0
CFTR	1846.0	333.0
CLSPN	-92.0	-8254.0
CYLD	6950.0	-7970.0
DDB2	4071.0	-6769.0
DDX58	-5895.0	3913.0
EP300	1364.0	2866.0
ESR1	8600.0	6696.0
FKBP8	-1695.0	7701.0
FOXK1	-1698.0	2345.0
FOXK2	4330.0	-4119.0
FOXO4	-8609.0	8547.0
GATA3	-1419.0	4322.0
H2AC1	-3686.0	4495.0
H2AC21	-2669.0	4180.0
H2BC1	-7751.0	2405.0
H2BC11	6509.0	1218.0
H2BC12	-3358.0	-6907.0
H2BC3	-3382.0	-5819.0
H2BU1	5369.0	-6065.0
HCFC1	-6300.0	-3186.0
HGS	-5517.0	7748.0
HIF1A	-6242.0	-6737.0
IDE	-7664.0	-264.0
IFIH1	-1718.0	-2808.0
IKBKG	2865.0	5671.0
IL33	5523.0	3011.0
INO80	-1033.0	-7154.0
INO80B	-3376.5	6608.5
INO80C	-5856.0	6018.0
INO80D	962.0	-2760.0
INO80E	-5894.0	7220.0
JOSD1	5816.0	3858.0
JOSD2	4439.0	3396.0
KAT2A	-5831.0	5172.0
KAT2B	2695.0	5911.0
KDM1B	-2871.0	-6194.0
KEAP1	297.0	6401.0
MAP3K7	2561.0	-3604.0
MAT2B	7935.0	7964.0
MAVS	-3868.0	8125.0
MBD5	-2073.0	5995.0
MBD6	-1151.0	-1400.0
MCRS1	-1661.0	1040.0
MDM2	-7130.0	6576.0
MDM4	5289.0	-2384.0
MUL1	-6342.0	5748.0
MYC	-7858.0	5713.0
MYSM1	8058.0	-3729.0
NEDD8	4019.0	7619.0
NFRKB	-8253.0	8027.0
NLRP3	3861.0	-7951.0
NOD1	-182.0	7988.0
NOD2	-8346.0	-3204.0
OGT	8384.0	-7828.0
OTUB1	-2328.0	5854.0
OTUB2	-1884.0	3640.0
OTUD3	8270.0	6551.0
OTUD5	-65.0	4535.0
OTUD7A	-2806.0	-3460.0
OTUD7B	-6269.0	3273.0
POLB	1927.0	2472.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
PTEN	-2571.0	6959.0
PTRH2	1449.0	-4963.0
RAD23A	-8502.0	8501.0
RAD23B	4713.0	5544.0
RCE1	5958.0	2666.0
RHOA	-580.0	1949.0
RHOT1	8437.0	8316.0
RIPK1	-1513.0	-5850.0
RIPK2	-3840.0	-1651.0
RNF123	-4505.0	5026.0
RNF128	8158.0	-3832.0
RNF146	-4369.0	2991.0
RPS27A	7076.0	2193.0
RUVBL1	-7628.0	8138.0
SENP8	-1405.0	462.0
SIAH2	-1051.0	-3718.0
SKP2	-5129.0	-4161.0
SMAD1	-608.0	-4245.0
SMAD2	7209.0	-8313.0
SMAD3	-28.0	-3448.0
SMAD4	-6666.0	-5029.0
SMAD7	8028.0	5135.0
SMURF2	14.0	2516.0
STAM	-5733.0	-1531.0
STAM2	-549.0	-1782.0
STAMBP	1696.0	3828.0
STAMBPL1	6931.0	-2722.0
SUDS3	1117.0	3749.0
TAB1	-5854.0	3142.0
TADA2B	-1518.0	3579.0
TADA3	1780.0	5323.0
TAF10	5176.0	6868.0
TAF9B	6616.0	-3374.0
TFPT	-2214.0	1904.0
TGFB1	-1002.0	-1450.0
TGFBR1	6837.0	-6198.0
TGFBR2	3599.0	5798.0
TNFAIP3	-7045.0	6507.0
TNIP1	-8487.0	8375.0
TNIP2	-2878.0	7130.0
TNIP3	-4245.0	3635.0
TNKS	6736.0	-5982.0
TNKS2	-6786.0	-2463.0
TOMM20	15.0	3071.0
TOMM70	2750.0	2724.0
TRAF2	1424.0	6511.0
TRAF3	7063.0	5059.0
TRAF6	-1959.0	-329.0
TRIM25	-4941.0	-976.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
UBE2D1	-1110.0	3081.0
UCHL1	4954.0	-3079.0
UCHL3	-1605.0	-4054.0
UCHL5	-1993.0	1699.0
UIMC1	-6823.0	7232.0
USP10	-5417.0	3778.0
USP11	-6482.0	4108.0
USP12	-8193.0	5313.0
USP13	1864.0	6883.0
USP14	-3271.0	5010.0
USP15	6879.0	8111.0
USP16	6437.0	3357.0
USP18	-6573.5	-2131.5
USP19	-5888.0	7462.0
USP2	-8157.0	8661.0
USP20	-8006.0	8644.0
USP21	-6026.0	6346.0
USP22	-6545.0	-1973.0
USP24	-194.0	4499.0
USP25	6660.0	8353.0
USP28	4076.0	-1158.0
USP3	-3709.0	-2364.0
USP30	-7166.0	7213.0
USP33	-108.0	-1878.0
USP34	3718.0	-2472.0
USP37	3682.0	-5988.0
USP4	-7997.0	8271.0
USP42	-2706.0	-5473.0
USP44	5815.0	-1743.0
USP47	-3614.0	5898.0
USP48	3375.0	7569.0
USP49	-2086.0	3550.0
USP5	4051.0	7386.0
USP7	3110.0	-5028.0
USP8	-1621.0	1217.0
USP9X	-1880.0	-2686.0
VCP	-3107.0	6482.0
VCPIP1	1760.0	-3713.0
VDAC1	-3136.0	4155.0
VDAC2	1638.0	6094.0
VDAC3	-138.0	2845.0
WDR20	8113.0	490.0
WDR48	-6235.0	3938.0
YOD1	5836.0	2178.0
YY1	2156.0	2313.0
ZRANB1	6385.0	2239.0

---

---

SCF-beta-TrCP mediated degradation of Emi1

SCF-beta-TrCP mediated degradation of Emi1

metric	value
setSize	52
pMANOVA	2.15e-06
p.adjustMANOVA	6.33e-05
s.dist	0.407
s.skel	0.067
s.heart	0.402
p.skel	0.403
p.heart	5.35e-07

Top 20 genes

Gene	skel	heart
PSMB8	7349.0	8633.0
PSMB6	7465.0	5963.0
PSMA4	7919.0	5418.0
PSMA6	5158.0	7228.0
PSMC2	5868.0	5306.0
PSMC1	3673.0	7505.0
PSMA2	5381.5	4713.5
PSMD6	5690.0	4320.0
PSMD5	5395.0	4547.0
PSMA7	5019.0	3863.0
PSME2	6732.0	2469.0
RPS27A	7076.0	2193.0
PSME4	2756.0	5110.0
FBXO5	4692.0	2621.0
PSMD2	2064.0	4576.0
PSMB1	1753.0	5095.0
FZR1	4259.0	1903.0
SKP1	944.0	7264.0
PSMC6	4466.0	1448.0
PSMD12	1500.0	3123.0

Click HERE to show all gene set members

All member genes

	skel	heart
BTRC	5925.0	-1783.0
CDC20	-7220.0	-8234.0
CUL1	-2470.0	5696.0
FBXO5	4692.0	2621.0
FZR1	4259.0	1903.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RPS27A	7076.0	2193.0
SKP1	944.0	7264.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0

---

---

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

metric	value
setSize	63
pMANOVA	2.25e-06
p.adjustMANOVA	6.5e-05
s.dist	0.372
s.skel	-0.0194
s.heart	0.371
p.skel	0.79
p.heart	3.43e-07

Top 20 genes

Gene	skel	heart
UBE2D3	-7793	7072
PSMB9	-7590	6708
PSMD11	-8283	5672
PSMD1	-5118	8590
ELOC	-6650	5809
PSMA8	-5126	6412
PSMB7	-5015	5872
PSMD3	-5302	5397
EGLN2	-3832	7309
CUL2	-3529	7078
EPAS1	-6815	3574
PSMC3	-4588	4871
PSMD7	-3537	5839
HIF3A	-5525	3693
PSMD4	-2843	6907
PSMC4	-4019	4642
PSME1	-2771	6314
PSMB2	-5719	2861
UBA52	-1940	7240
PSME3	-8528	1402

Click HERE to show all gene set members

All member genes

	skel	heart
AJUBA	-5124.0	-5304.0
CUL2	-3529.0	7078.0
EGLN1	7948.5	8268.5
EGLN2	-3832.0	7309.0
EGLN3	-695.0	4593.0
ELOB	-275.0	-4953.0
ELOC	-6650.0	5809.0
EPAS1	-6815.0	3574.0
HIF1A	-6242.0	-6737.0
HIF3A	-5525.0	3693.0
LIMD1	-7091.0	-222.0
PSMA1	2067.0	1803.0
PSMA2	5381.5	4713.5
PSMA3	7438.0	-718.0
PSMA4	7919.0	5418.0
PSMA5	3583.0	5.0
PSMA6	5158.0	7228.0
PSMA7	5019.0	3863.0
PSMA8	-5126.0	6412.0
PSMB1	1753.0	5095.0
PSMB10	-8118.0	-1142.0
PSMB2	-5719.0	2861.0
PSMB3	1506.0	383.0
PSMB4	1768.0	1526.0
PSMB5	-1735.0	6793.0
PSMB6	7465.0	5963.0
PSMB7	-5015.0	5872.0
PSMB8	7349.0	8633.0
PSMB9	-7590.0	6708.0
PSMC1	3673.0	7505.0
PSMC2	5868.0	5306.0
PSMC3	-4588.0	4871.0
PSMC4	-4019.0	4642.0
PSMC5	339.0	4241.0
PSMC6	4466.0	1448.0
PSMD1	-5118.0	8590.0
PSMD10	-1528.0	4981.0
PSMD11	-8283.0	5672.0
PSMD12	1500.0	3123.0
PSMD13	3383.0	-2699.0
PSMD14	546.0	6040.0
PSMD2	2064.0	4576.0
PSMD3	-5302.0	5397.0
PSMD4	-2843.0	6907.0
PSMD5	5395.0	4547.0
PSMD6	5690.0	4320.0
PSMD7	-3537.0	5839.0
PSMD8	-967.0	5567.0
PSMD9	1369.5	-2678.5
PSME1	-2771.0	6314.0
PSME2	6732.0	2469.0
PSME3	-8528.0	1402.0
PSME4	2756.0	5110.0
PSMF1	2279.0	-1399.0
RBX1	92.0	4055.0
RPS27A	7076.0	2193.0
UBA52	-1940.0	7240.0
UBC	-6162.0	94.0
UBE2D1	-1110.0	3081.0
UBE2D2	1743.0	119.0
UBE2D3	-7793.0	7072.0
VHL	4817.0	-4547.0
WTIP	4469.0	-1972.0

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] ggplot2_3.3.2               beeswarm_0.2.3             
##  [5] gtools_3.8.2                tibble_3.0.4               
##  [7] dplyr_1.0.2                 echarts4r_0.3.3            
##  [9] gplots_3.1.0                mitch_1.2.2                
## [11] DESeq2_1.30.0               SummarizedExperiment_1.20.0
## [13] Biobase_2.50.0              MatrixGenerics_1.2.0       
## [15] matrixStats_0.57.0          GenomicRanges_1.42.0       
## [17] GenomeInfoDb_1.26.0         IRanges_2.24.0             
## [19] S4Vectors_0.28.0            BiocGenerics_0.36.0        
## [21] reshape2_1.4.4             
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-6           bit64_4.0.5            RColorBrewer_1.1-2    
##  [4] httr_1.4.2             rprojroot_1.3-2        tools_4.0.3           
##  [7] backports_1.2.0        R6_2.5.0               KernSmooth_2.23-18    
## [10] DBI_1.1.0              colorspace_2.0-0       withr_2.3.0           
## [13] tidyselect_1.1.0       gridExtra_2.3          bit_4.0.4             
## [16] compiler_4.0.3         desc_1.2.0             DelayedArray_0.16.0   
## [19] labeling_0.4.2         caTools_1.18.0         scales_1.1.1          
## [22] genefilter_1.72.0      stringr_1.4.0          digest_0.6.27         
## [25] rmarkdown_2.5          XVector_0.30.0         pkgconfig_2.0.3       
## [28] htmltools_0.5.0        fastmap_1.0.1          highr_0.8             
## [31] htmlwidgets_1.5.2      rlang_0.4.8            RSQLite_2.2.1         
## [34] shiny_1.5.0            farver_2.0.3           generics_0.1.0        
## [37] jsonlite_1.7.1         BiocParallel_1.24.1    RCurl_1.98-1.2        
## [40] magrittr_1.5           GenomeInfoDbData_1.2.4 Matrix_1.2-18         
## [43] Rcpp_1.0.5             munsell_0.5.0          lifecycle_0.2.0       
## [46] stringi_1.5.3          yaml_2.2.1             MASS_7.3-53           
## [49] zlibbioc_1.36.0        plyr_1.8.6             grid_4.0.3            
## [52] blob_1.2.1             promises_1.1.1         crayon_1.3.4          
## [55] lattice_0.20-41        splines_4.0.3          annotate_1.68.0       
## [58] locfit_1.5-9.4         knitr_1.30             pillar_1.4.6          
## [61] geneplotter_1.68.0     XML_3.99-0.5           glue_1.4.2            
## [64] evaluate_0.14          vctrs_0.3.4            httpuv_1.5.4          
## [67] testthat_3.0.0         gtable_0.3.0           purrr_0.3.4           
## [70] reshape_0.8.8          assertthat_0.2.1       xfun_0.19             
## [73] mime_0.9               xtable_1.8-4           later_1.1.0.1         
## [76] survival_3.2-7         AnnotationDbi_1.52.0   memoise_1.1.0         
## [79] ellipsis_0.3.1

END of report