Mitch Report

date generated: 2023-11-14

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	mean
PRDM16	0.6501046
CDH4	0.6997851
SEPT9	0.6428529
KCNQ1	0.5587846
GNAS	0.6544056
SHANK2	0.4526450

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2584
num_genes_in_profile	25739
duplicated_genes_present	0
num_profile_genes_in_sets	10218
num_profile_genes_not_in_sets	15521

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways.gmt

Gene set metrics

	Gene sets metrics
num_genesets	2584
num_genesets_excluded	1038
num_genesets_included	1546

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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set	setSize	pANOVA	s.dist	p.adjustANOVA
SUMOylation of immune response proteins	10	2.49e-03	0.552	4.81e-02
Chylomicron remodeling	10	2.54e-03	0.551	4.81e-02
SARS-CoV-1 modulates host translation machinery	34	1.73e-07	0.518	9.54e-06
Josephin domain DUBs	11	5.49e-03	0.483	7.99e-02
TRAF6 mediated IRF7 activation	26	3.55e-05	-0.468	1.26e-03
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	6.08e-07	-0.461	3.24e-05
Pexophagy	11	8.89e-03	0.455	1.13e-01
Phase 4 - resting membrane potential	19	1.10e-03	0.432	2.70e-02
Interaction With Cumulus Cells And The Zona Pellucida	11	1.43e-02	-0.426	1.53e-01
Expression and translocation of olfactory receptors	358	3.01e-42	-0.418	4.65e-39
NF-kB is activated and signals survival	12	1.25e-02	0.416	1.42e-01
Peptide chain elongation	84	6.63e-11	0.412	1.28e-08
Regulation of NF-kappa B signaling	17	3.41e-03	0.410	5.93e-02
Olfactory Signaling Pathway	365	3.28e-41	-0.409	2.53e-38
Viral mRNA Translation	84	1.32e-10	0.405	2.06e-08
APC/C:Cdc20 mediated degradation of Cyclin B	24	6.62e-04	0.401	1.80e-02
Eukaryotic Translation Termination	87	1.35e-10	0.398	2.06e-08
Eukaryotic Translation Elongation	88	1.47e-10	0.395	2.06e-08
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	1.83e-02	-0.393	1.74e-01
Selenocysteine synthesis	87	1.02e-09	0.378	1.26e-07
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	1.18e-09	0.373	1.26e-07
NRIF signals cell death from the nucleus	16	1.00e-02	0.372	1.23e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	10	4.44e-02	0.367	2.91e-01
Intrinsic Pathway of Fibrin Clot Formation	21	3.81e-03	-0.365	6.33e-02
Tandem pore domain potassium channels	12	2.88e-02	0.365	2.29e-01
Regulation of IFNA/IFNB signaling	22	3.31e-03	-0.362	5.89e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	1.17e-09	0.361	1.26e-07
Formation of a pool of free 40S subunits	94	1.71e-09	0.359	1.65e-07
Signaling by cytosolic FGFR1 fusion mutants	17	1.08e-02	-0.357	1.31e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	7.68e-05	-0.357	2.42e-03
Pausing and recovery of Tat-mediated HIV elongation	27	1.37e-03	0.356	3.07e-02
Tat-mediated HIV elongation arrest and recovery	27	1.37e-03	0.356	3.07e-02
Caspase activation via Death Receptors in the presence of ligand	16	1.42e-02	-0.354	1.53e-01
p75NTR recruits signalling complexes	12	3.56e-02	0.350	2.54e-01
HIV elongation arrest and recovery	29	1.16e-03	0.348	2.70e-02
Pausing and recovery of HIV elongation	29	1.16e-03	0.348	2.70e-02
Formation of the ternary complex, and subsequently, the 43S complex	46	4.47e-05	0.348	1.50e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	4.67e-02	0.346	2.92e-01
Interleukin-15 signaling	13	3.08e-02	-0.346	2.37e-01
SARS-CoV-2 modulates host translation machinery	46	6.31e-05	0.341	2.03e-03
Selenoamino acid metabolism	103	3.25e-09	0.337	2.65e-07
Attenuation phase	25	3.51e-03	0.337	5.97e-02
Chylomicron assembly	10	6.52e-02	0.337	3.41e-01
L13a-mediated translational silencing of Ceruloplasmin expression	103	4.02e-09	0.335	2.96e-07
Platelet Adhesion to exposed collagen	13	3.66e-02	-0.335	2.57e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	104	3.93e-09	0.334	2.96e-07
Biosynthesis of DHA-derived SPMs	17	1.73e-02	0.334	1.68e-01
Ribosomal scanning and start codon recognition	53	2.82e-05	0.332	1.12e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	54	2.39e-05	0.332	9.97e-04
Translation initiation complex formation	53	3.12e-05	0.331	1.18e-03

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
SUMOylation of immune response proteins	10	2.49e-03	0.552000	4.81e-02
Chylomicron remodeling	10	2.54e-03	0.551000	4.81e-02
SARS-CoV-1 modulates host translation machinery	34	1.73e-07	0.518000	9.54e-06
Josephin domain DUBs	11	5.49e-03	0.483000	7.99e-02
TRAF6 mediated IRF7 activation	26	3.55e-05	-0.468000	1.26e-03
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	6.08e-07	-0.461000	3.24e-05
Pexophagy	11	8.89e-03	0.455000	1.13e-01
Phase 4 - resting membrane potential	19	1.10e-03	0.432000	2.70e-02
Interaction With Cumulus Cells And The Zona Pellucida	11	1.43e-02	-0.426000	1.53e-01
Expression and translocation of olfactory receptors	358	3.01e-42	-0.418000	4.65e-39
NF-kB is activated and signals survival	12	1.25e-02	0.416000	1.42e-01
Peptide chain elongation	84	6.63e-11	0.412000	1.28e-08
Regulation of NF-kappa B signaling	17	3.41e-03	0.410000	5.93e-02
Olfactory Signaling Pathway	365	3.28e-41	-0.409000	2.53e-38
Viral mRNA Translation	84	1.32e-10	0.405000	2.06e-08
APC/C:Cdc20 mediated degradation of Cyclin B	24	6.62e-04	0.401000	1.80e-02
Eukaryotic Translation Termination	87	1.35e-10	0.398000	2.06e-08
Eukaryotic Translation Elongation	88	1.47e-10	0.395000	2.06e-08
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	1.83e-02	-0.393000	1.74e-01
Selenocysteine synthesis	87	1.02e-09	0.378000	1.26e-07
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	1.18e-09	0.373000	1.26e-07
NRIF signals cell death from the nucleus	16	1.00e-02	0.372000	1.23e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	10	4.44e-02	0.367000	2.91e-01
Intrinsic Pathway of Fibrin Clot Formation	21	3.81e-03	-0.365000	6.33e-02
Tandem pore domain potassium channels	12	2.88e-02	0.365000	2.29e-01
Regulation of IFNA/IFNB signaling	22	3.31e-03	-0.362000	5.89e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	1.17e-09	0.361000	1.26e-07
Formation of a pool of free 40S subunits	94	1.71e-09	0.359000	1.65e-07
Signaling by cytosolic FGFR1 fusion mutants	17	1.08e-02	-0.357000	1.31e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	7.68e-05	-0.357000	2.42e-03
Pausing and recovery of Tat-mediated HIV elongation	27	1.37e-03	0.356000	3.07e-02
Tat-mediated HIV elongation arrest and recovery	27	1.37e-03	0.356000	3.07e-02
Caspase activation via Death Receptors in the presence of ligand	16	1.42e-02	-0.354000	1.53e-01
p75NTR recruits signalling complexes	12	3.56e-02	0.350000	2.54e-01
HIV elongation arrest and recovery	29	1.16e-03	0.348000	2.70e-02
Pausing and recovery of HIV elongation	29	1.16e-03	0.348000	2.70e-02
Formation of the ternary complex, and subsequently, the 43S complex	46	4.47e-05	0.348000	1.50e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	4.67e-02	0.346000	2.92e-01
Interleukin-15 signaling	13	3.08e-02	-0.346000	2.37e-01
SARS-CoV-2 modulates host translation machinery	46	6.31e-05	0.341000	2.03e-03
Selenoamino acid metabolism	103	3.25e-09	0.337000	2.65e-07
Attenuation phase	25	3.51e-03	0.337000	5.97e-02
Chylomicron assembly	10	6.52e-02	0.337000	3.41e-01
L13a-mediated translational silencing of Ceruloplasmin expression	103	4.02e-09	0.335000	2.96e-07
Platelet Adhesion to exposed collagen	13	3.66e-02	-0.335000	2.57e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	104	3.93e-09	0.334000	2.96e-07
Biosynthesis of DHA-derived SPMs	17	1.73e-02	0.334000	1.68e-01
Ribosomal scanning and start codon recognition	53	2.82e-05	0.332000	1.12e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	54	2.39e-05	0.332000	9.97e-04
Translation initiation complex formation	53	3.12e-05	0.331000	1.18e-03
p75NTR signals via NF-kB	15	2.70e-02	0.330000	2.19e-01
Assembly Of The HIV Virion	16	2.25e-02	0.330000	1.92e-01
Downregulation of ERBB2:ERBB3 signaling	13	4.02e-02	0.329000	2.76e-01
Regulation of signaling by NODAL	10	7.45e-02	0.326000	3.58e-01
Metabolism of folate and pterines	16	2.41e-02	-0.326000	2.00e-01
Cap-dependent Translation Initiation	111	3.04e-09	0.326000	2.61e-07
Eukaryotic Translation Initiation	111	3.04e-09	0.326000	2.61e-07
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	108	5.73e-09	0.324000	3.54e-07
Nonsense-Mediated Decay (NMD)	108	5.73e-09	0.324000	3.54e-07
Membrane binding and targetting of GAG proteins	14	3.60e-02	0.324000	2.54e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	3.60e-02	0.324000	2.54e-01
STAT5 activation downstream of FLT3 ITD mutants	10	7.65e-02	-0.323000	3.63e-01
APC-Cdc20 mediated degradation of Nek2A	26	4.39e-03	0.323000	6.92e-02
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	16	2.81e-02	0.317000	2.26e-01
HSF1 activation	27	4.38e-03	0.317000	6.92e-02
Major pathway of rRNA processing in the nucleolus and cytosol	171	1.05e-12	0.315000	4.06e-10
Recycling of bile acids and salts	18	2.08e-02	-0.315000	1.84e-01
CYP2E1 reactions	11	7.18e-02	-0.313000	3.52e-01
Alpha-protein kinase 1 signaling pathway	10	8.69e-02	0.313000	3.92e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	4.35e-02	0.312000	2.86e-01
Prednisone ADME	10	8.79e-02	-0.312000	3.94e-01
HSF1-dependent transactivation	35	1.50e-03	0.310000	3.26e-02
Zinc influx into cells by the SLC39 gene family	10	8.96e-02	0.310000	3.97e-01
Keratan sulfate degradation	12	6.41e-02	-0.309000	3.38e-01
NPAS4 regulates expression of target genes	21	1.51e-02	0.306000	1.55e-01
Aggrephagy	23	1.19e-02	0.303000	1.37e-01
Synthesis of glycosylphosphatidylinositol (GPI)	17	3.12e-02	0.302000	2.37e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	1.47e-02	0.301000	1.53e-01
SRP-dependent cotranslational protein targeting to membrane	105	1.14e-07	0.299000	6.55e-06
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	7.31e-02	0.299000	3.56e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	4.51e-02	0.299000	2.92e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	4.51e-02	0.299000	2.92e-01
rRNA processing in the nucleus and cytosol	180	4.64e-12	0.299000	1.44e-09
Golgi Cisternae Pericentriolar Stack Reorganization	14	5.48e-02	0.296000	3.17e-01
Signal regulatory protein family interactions	13	7.01e-02	-0.290000	3.47e-01
Cellular response to starvation	147	1.22e-09	0.290000	1.26e-07
Chemokine receptors bind chemokines	56	1.81e-04	-0.289000	5.37e-03
rRNA processing	186	1.48e-11	0.287000	3.81e-09
Regulation of localization of FOXO transcription factors	11	1.02e-01	0.285000	4.17e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	1.22e-01	0.283000	4.56e-01
Cytosolic iron-sulfur cluster assembly	10	1.22e-01	0.283000	4.56e-01
mRNA Editing	10	1.23e-01	-0.282000	4.57e-01
Synthesis of PIPs at the late endosome membrane	10	1.24e-01	-0.281000	4.58e-01
Interleukin-2 family signaling	40	2.17e-03	-0.280000	4.41e-02
Regulation of innate immune responses to cytosolic DNA	14	6.99e-02	0.280000	3.47e-01
TRAF3-dependent IRF activation pathway	15	6.22e-02	-0.278000	3.33e-01
Mitochondrial iron-sulfur cluster biogenesis	12	9.53e-02	0.278000	4.07e-01
HDL remodeling	10	1.29e-01	0.277000	4.69e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	3.38e-02	0.274000	2.47e-01
Diseases associated with glycosylation precursor biosynthesis	15	6.63e-02	0.274000	3.41e-01
Assembly of active LPL and LIPC lipase complexes	17	5.16e-02	0.273000	3.12e-01
Glutamate and glutamine metabolism	12	1.03e-01	0.272000	4.17e-01
Influenza Viral RNA Transcription and Replication	129	9.45e-08	0.272000	5.62e-06
Sensory Perception	569	1.16e-28	-0.272000	5.97e-26
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	4.83e-03	0.271000	7.39e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	1.41e-01	0.269000	4.88e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	2.00e-02	0.269000	1.80e-01
Regulation of expression of SLITs and ROBOs	159	4.83e-09	0.269000	3.25e-07
Glucuronidation	25	2.03e-02	-0.268000	1.82e-01
Pregnenolone biosynthesis	10	1.49e-01	0.263000	4.99e-01
Synthesis of PIPs at the early endosome membrane	15	7.82e-02	-0.263000	3.66e-01
Spry regulation of FGF signaling	16	6.96e-02	0.262000	3.47e-01
Sensory perception of taste	47	1.98e-03	-0.261000	4.09e-02
VLDLR internalisation and degradation	16	7.47e-02	0.257000	3.58e-01
Interleukin-6 signaling	11	1.41e-01	-0.256000	4.88e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	8.57e-02	-0.256000	3.90e-01
rRNA modification in the nucleus and cytosol	55	1.06e-03	0.255000	2.63e-02
XBP1(S) activates chaperone genes	47	2.55e-03	0.254000	4.81e-02
Formation of TC-NER Pre-Incision Complex	51	1.70e-03	0.254000	3.65e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat	38	6.79e-03	0.254000	9.05e-02
HIV Transcription Elongation	38	6.79e-03	0.254000	9.05e-02
Tat-mediated elongation of the HIV-1 transcript	38	6.79e-03	0.254000	9.05e-02
ERKs are inactivated	13	1.14e-01	0.253000	4.40e-01
Formation of HIV elongation complex in the absence of HIV Tat	40	5.53e-03	0.253000	7.99e-02
Biosynthesis of specialized proresolving mediators (SPMs)	19	5.59e-02	0.253000	3.21e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	1.14e-01	0.253000	4.41e-01
SARS-CoV-1-host interactions	90	3.68e-05	0.252000	1.26e-03
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	5.82e-02	0.251000	3.23e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	5.82e-02	0.251000	3.23e-01
IRE1alpha activates chaperones	49	2.40e-03	0.251000	4.71e-02
Phosphorylation of the APC/C	20	5.26e-02	0.250000	3.13e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	3.11e-02	0.249000	2.37e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	4.01e-02	0.247000	2.76e-01
Diseases of mitotic cell cycle	37	9.69e-03	0.246000	1.21e-01
RNA Polymerase III Transcription Termination	23	4.17e-02	0.245000	2.80e-01
Defensins	36	1.12e-02	-0.244000	1.31e-01
Signaling by EGFR in Cancer	25	3.49e-02	0.244000	2.52e-01
TICAM1-dependent activation of IRF3/IRF7	12	1.44e-01	0.244000	4.94e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	20	5.99e-02	-0.243000	3.27e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	1.03e-01	-0.243000	4.17e-01
RNA Polymerase III Chain Elongation	18	7.51e-02	0.242000	3.58e-01
Interleukin-2 signaling	11	1.65e-01	-0.242000	5.32e-01
Regulated proteolysis of p75NTR	11	1.65e-01	0.242000	5.32e-01
RNA Pol II CTD phosphorylation and interaction with CE	26	3.38e-02	0.240000	2.47e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	3.38e-02	0.240000	2.47e-01
mRNA Splicing - Minor Pathway	51	3.06e-03	0.240000	5.64e-02
Triglyceride catabolism	23	4.68e-02	-0.239000	2.92e-01
MyD88 deficiency (TLR2/4)	16	1.01e-01	-0.237000	4.17e-01
Cell-extracellular matrix interactions	14	1.26e-01	0.236000	4.60e-01
DAP12 interactions	40	1.04e-02	-0.234000	1.26e-01
Bile acid and bile salt metabolism	45	6.64e-03	-0.234000	9.05e-02
Vitamin B5 (pantothenate) metabolism	16	1.06e-01	-0.233000	4.24e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	7.26e-02	0.232000	3.55e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	6.71e-02	0.231000	3.41e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	6.71e-02	0.231000	3.41e-01
Regulation of TLR by endogenous ligand	17	9.98e-02	-0.231000	4.17e-01
Glycogen storage diseases	14	1.35e-01	0.230000	4.81e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	1.67e-02	0.230000	1.66e-01
Methylation	14	1.37e-01	0.230000	4.82e-01
Signaling by NODAL	21	6.87e-02	0.229000	3.46e-01
RNA Polymerase I Transcription Termination	27	4.01e-02	0.228000	2.76e-01
Formation of RNA Pol II elongation complex	53	4.13e-03	0.228000	6.69e-02
RNA Polymerase II Transcription Elongation	53	4.13e-03	0.228000	6.69e-02
Translesion Synthesis by POLH	19	8.80e-02	0.226000	3.94e-01
Phospholipase C-mediated cascade: FGFR1	16	1.18e-01	0.226000	4.52e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	9.86e-02	0.225000	4.16e-01
Senescence-Associated Secretory Phenotype (SASP)	53	4.91e-03	0.223000	7.40e-02
Gap-filling DNA repair synthesis and ligation in TC-NER	62	2.39e-03	0.223000	4.71e-02
Formation of Fibrin Clot (Clotting Cascade)	37	1.91e-02	-0.223000	1.78e-01
Negative regulation of FGFR1 signaling	32	2.95e-02	0.222000	2.33e-01
DNA Damage Recognition in GG-NER	36	2.22e-02	0.220000	1.91e-01
Influenza Infection	148	3.83e-06	0.220000	1.74e-04
FGFRL1 modulation of FGFR1 signaling	13	1.71e-01	0.219000	5.44e-01
Transcriptional Regulation by NPAS4	33	3.03e-02	0.218000	2.36e-01
CASP8 activity is inhibited	11	2.11e-01	-0.218000	5.99e-01
Dimerization of procaspase-8	11	2.11e-01	-0.218000	5.99e-01
Regulation by c-FLIP	11	2.11e-01	-0.218000	5.99e-01
Mitochondrial translation initiation	87	4.54e-04	0.217000	1.30e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	2.22e-02	0.217000	1.91e-01
Signaling by Leptin	11	2.14e-01	-0.217000	6.02e-01
FGFR1 ligand binding and activation	15	1.46e-01	0.217000	4.94e-01
Hh mutants are degraded by ERAD	54	5.96e-03	0.216000	8.46e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	1.13e-01	0.216000	4.40e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.17e-03	0.215000	2.70e-02
Inhibition of DNA recombination at telomere	20	9.59e-02	0.215000	4.08e-01
Incretin synthesis, secretion, and inactivation	23	7.49e-02	-0.215000	3.58e-01
Activation of RAC1	11	2.19e-01	-0.214000	6.09e-01
TAK1-dependent IKK and NF-kappa-B activation	41	1.84e-02	0.213000	1.74e-01
Lysine catabolism	12	2.03e-01	-0.212000	5.89e-01
Aspirin ADME	44	1.54e-02	-0.211000	1.55e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	2.26e-01	0.211000	6.14e-01
TP53 Regulates Transcription of DNA Repair Genes	57	5.91e-03	0.211000	8.46e-02
Autodegradation of Cdh1 by Cdh1:APC/C	62	4.16e-03	0.210000	6.69e-02
Translation	262	4.37e-09	0.210000	3.07e-07
Mitochondrial translation elongation	87	6.92e-04	0.210000	1.85e-02
Degradation of cysteine and homocysteine	14	1.75e-01	0.210000	5.46e-01
NOTCH2 intracellular domain regulates transcription	11	2.30e-01	-0.209000	6.18e-01
Interconversion of nucleotide di- and triphosphates	29	5.13e-02	0.209000	3.11e-01
Ketone body metabolism	10	2.53e-01	-0.209000	6.51e-01
SCF(Skp2)-mediated degradation of p27/p21	58	6.02e-03	0.208000	8.46e-02
Mitochondrial translation termination	87	7.84e-04	0.208000	2.05e-02
ER Quality Control Compartment (ERQC)	20	1.09e-01	0.207000	4.27e-01
Mitochondrial translation	93	5.97e-04	0.206000	1.68e-02
DAP12 signaling	28	6.05e-02	-0.205000	3.30e-01
IRAK4 deficiency (TLR2/4)	17	1.44e-01	-0.204000	4.94e-01
Formation of the Early Elongation Complex	32	4.62e-02	0.204000	2.92e-01
Formation of the HIV-1 Early Elongation Complex	32	4.62e-02	0.204000	2.92e-01
Plasma lipoprotein remodeling	32	4.63e-02	0.203000	2.92e-01
Beta defensins	28	6.29e-02	-0.203000	3.35e-01
Regulation of FZD by ubiquitination	21	1.08e-01	0.203000	4.26e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	6.91e-02	0.202000	3.46e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	1.12e-02	0.201000	1.31e-01
Hormone ligand-binding receptors	13	2.09e-01	-0.201000	5.99e-01
Sema4D induced cell migration and growth-cone collapse	20	1.19e-01	0.201000	4.53e-01
CDK-mediated phosphorylation and removal of Cdc6	71	3.42e-03	0.201000	5.93e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	3.47e-03	0.201000	5.96e-02
Deactivation of the beta-catenin transactivating complex	39	3.03e-02	0.200000	2.36e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	3.30e-03	0.200000	5.89e-02
N-Glycan antennae elongation	15	1.80e-01	-0.200000	5.56e-01
Activation of HOX genes during differentiation	61	7.10e-03	0.199000	9.30e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis	61	7.10e-03	0.199000	9.30e-02
Negative regulation of FGFR4 signaling	30	5.98e-02	0.198000	3.27e-01
APC/C:Cdc20 mediated degradation of Securin	66	5.34e-03	0.198000	7.86e-02
Tie2 Signaling	18	1.46e-01	-0.198000	4.94e-01
SUMOylation of transcription factors	20	1.25e-01	0.198000	4.59e-01
RHO GTPases activate PKNs	34	4.57e-02	0.198000	2.92e-01
Signaling by BMP	27	7.76e-02	-0.196000	3.66e-01
AKT phosphorylates targets in the cytosol	14	2.07e-01	0.195000	5.95e-01
mRNA Capping	28	7.43e-02	0.195000	3.58e-01
Negative regulation of FGFR2 signaling	33	5.30e-02	0.195000	3.13e-01
Interleukin-20 family signaling	24	9.89e-02	-0.195000	4.16e-01
Other interleukin signaling	24	9.92e-02	0.194000	4.16e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	23	1.07e-01	0.194000	4.26e-01
Hh mutants abrogate ligand secretion	57	1.15e-02	0.193000	1.34e-01
Signaling by FLT3 fusion proteins	19	1.45e-01	-0.193000	4.94e-01
Constitutive Signaling by Overexpressed ERBB2	10	2.91e-01	0.193000	6.88e-01
Pyroptosis	26	8.86e-02	-0.193000	3.95e-01
LGI-ADAM interactions	14	2.11e-01	0.193000	6.00e-01
Synthesis of PE	12	2.48e-01	0.192000	6.45e-01
Interleukin-10 signaling	45	2.58e-02	-0.192000	2.10e-01
Eicosanoid ligand-binding receptors	14	2.14e-01	-0.192000	6.02e-01
Dual incision in TC-NER	63	8.40e-03	0.192000	1.07e-01
MAP2K and MAPK activation	36	4.64e-02	-0.192000	2.92e-01
RHOU GTPase cycle	37	4.47e-02	-0.191000	2.91e-01
Signaling by ROBO receptors	203	2.83e-06	0.190000	1.33e-04
APC/C:Cdc20 mediated degradation of mitotic proteins	74	4.63e-03	0.190000	7.24e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	1.74e-01	0.190000	5.46e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	1.74e-01	0.190000	5.46e-01
Zinc transporters	17	1.75e-01	0.190000	5.46e-01
cGMP effects	15	2.03e-01	-0.190000	5.89e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	1.09e-01	-0.189000	4.27e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	1.02e-01	-0.189000	4.17e-01
p38MAPK events	13	2.40e-01	0.188000	6.31e-01
RNA Polymerase I Promoter Escape	28	8.51e-02	0.188000	3.89e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	14	2.26e-01	-0.187000	6.14e-01
Diseases of hemostasis	14	2.26e-01	-0.187000	6.14e-01
Selective autophagy	59	1.31e-02	0.187000	1.46e-01
FGFR2 mutant receptor activation	32	6.78e-02	0.187000	3.43e-01
PI3K events in ERBB4 signaling	10	3.09e-01	-0.186000	6.98e-01
Phenylalanine and tyrosine metabolism	10	3.10e-01	0.185000	6.98e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	6.17e-02	0.185000	3.32e-01
Activated NOTCH1 Transmits Signal to the Nucleus	31	7.50e-02	0.185000	3.58e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	58	1.53e-02	0.184000	1.55e-01
Role of LAT2/NTAL/LAB on calcium mobilization	13	2.51e-01	-0.184000	6.49e-01
Defective CFTR causes cystic fibrosis	59	1.46e-02	0.184000	1.53e-01
Regulation of APC/C activators between G1/S and early anaphase	79	4.93e-03	0.183000	7.40e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	2.74e-01	-0.182000	6.70e-01
Synthesis of bile acids and bile salts	34	6.63e-02	-0.182000	3.41e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	6.57e-03	0.181000	9.05e-02
Retinoid metabolism and transport	42	4.19e-02	0.181000	2.80e-01
RNA Polymerase I Transcription	47	3.14e-02	0.181000	2.37e-01
p130Cas linkage to MAPK signaling for integrins	15	2.25e-01	-0.181000	6.14e-01
Chaperone Mediated Autophagy	19	1.73e-01	0.181000	5.46e-01
SCF-beta-TrCP mediated degradation of Emi1	53	2.28e-02	0.181000	1.94e-01
p53-Dependent G1 DNA Damage Response	64	1.29e-02	0.180000	1.45e-01
p53-Dependent G1/S DNA damage checkpoint	64	1.29e-02	0.180000	1.45e-01
Ubiquitin-dependent degradation of Cyclin D	50	2.82e-02	0.179000	2.26e-01
Common Pathway of Fibrin Clot Formation	21	1.56e-01	-0.179000	5.12e-01
Negative regulation of FGFR3 signaling	28	1.02e-01	0.178000	4.17e-01
Signaling by FGFR1	49	3.10e-02	0.178000	2.37e-01
GPVI-mediated activation cascade	32	8.21e-02	-0.178000	3.81e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	10	3.32e-01	-0.177000	7.20e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	5.90e-02	0.177000	3.26e-01
mRNA Splicing	184	3.58e-05	0.177000	1.26e-03
G1/S DNA Damage Checkpoints	66	1.34e-02	0.176000	1.48e-01
RHO GTPases activate CIT	19	1.85e-01	0.176000	5.61e-01
Phospholipase C-mediated cascade; FGFR4	14	2.56e-01	0.175000	6.52e-01
Induction of Cell-Cell Fusion	12	2.93e-01	0.175000	6.88e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	1.08e-01	0.175000	4.26e-01
Regulation of PTEN mRNA translation	25	1.29e-01	0.175000	4.69e-01
Folding of actin by CCT/TriC	10	3.39e-01	-0.175000	7.24e-01
Nucleotide Excision Repair	107	1.81e-03	0.175000	3.83e-02
Androgen biosynthesis	11	3.17e-01	-0.174000	7.03e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	31	9.34e-02	0.174000	4.02e-01
Pyrimidine salvage	10	3.41e-01	-0.174000	7.24e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	1.10e-02	0.173000	1.31e-01
Acyl chain remodelling of PE	24	1.43e-01	0.173000	4.92e-01
RNA Polymerase I Promoter Clearance	46	4.26e-02	0.173000	2.83e-01
Signaling by KIT in disease	20	1.82e-01	-0.172000	5.56e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	1.82e-01	-0.172000	5.56e-01
Translesion synthesis by POLI	17	2.19e-01	0.172000	6.09e-01
MECP2 regulates neuronal receptors and channels	17	2.20e-01	-0.172000	6.09e-01
Phospholipase C-mediated cascade; FGFR2	17	2.20e-01	0.172000	6.09e-01
Telomere C-strand synthesis initiation	11	3.25e-01	-0.171000	7.15e-01
RMTs methylate histone arginines	30	1.05e-01	0.171000	4.22e-01
SHC-mediated cascade:FGFR1	21	1.76e-01	0.171000	5.48e-01
Na+/Cl- dependent neurotransmitter transporters	18	2.10e-01	0.171000	5.99e-01
Calnexin/calreticulin cycle	25	1.40e-01	0.171000	4.88e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	34	8.56e-02	0.170000	3.90e-01
Hedgehog ligand biogenesis	63	1.94e-02	0.170000	1.79e-01
Mitotic Telophase/Cytokinesis	10	3.52e-01	-0.170000	7.37e-01
N-glycan antennae elongation in the medial/trans-Golgi	26	1.34e-01	-0.170000	4.80e-01
Autodegradation of the E3 ubiquitin ligase COP1	50	3.77e-02	0.170000	2.64e-01
RHOV GTPase cycle	36	7.81e-02	-0.170000	3.66e-01
Dectin-1 mediated noncanonical NF-kB signaling	60	2.33e-02	0.169000	1.96e-01
Fertilization	26	1.36e-01	-0.169000	4.81e-01
Signaling by NOTCH3	48	4.30e-02	0.169000	2.84e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	120	1.43e-03	-0.168000	3.17e-02
Transport of organic anions	10	3.57e-01	-0.168000	7.41e-01
Signaling by NTRK3 (TRKC)	17	2.31e-01	0.168000	6.18e-01
Gluconeogenesis	32	1.02e-01	0.167000	4.17e-01
mTORC1-mediated signalling	23	1.66e-01	0.167000	5.32e-01
Keratinization	213	2.66e-05	-0.167000	1.08e-03
Transcription of the HIV genome	62	2.33e-02	0.167000	1.96e-01
Positive epigenetic regulation of rRNA expression	43	5.95e-02	0.166000	3.27e-01
Sema4D in semaphorin signaling	24	1.60e-01	0.166000	5.21e-01
Recognition of DNA damage by PCNA-containing replication complex	29	1.22e-01	0.166000	4.56e-01
Organic cation transport	10	3.65e-01	-0.165000	7.41e-01
CD209 (DC-SIGN) signaling	20	2.01e-01	-0.165000	5.88e-01
Fanconi Anemia Pathway	36	8.64e-02	0.165000	3.91e-01
Neurotoxicity of clostridium toxins	10	3.66e-01	0.165000	7.41e-01
Other semaphorin interactions	18	2.26e-01	-0.165000	6.14e-01
B-WICH complex positively regulates rRNA expression	29	1.24e-01	0.165000	4.58e-01
ABC transporter disorders	75	1.37e-02	0.165000	1.50e-01
RNA Polymerase II Pre-transcription Events	73	1.53e-02	0.164000	1.55e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	2.72e-01	0.164000	6.68e-01
Prolactin receptor signaling	15	2.72e-01	-0.164000	6.68e-01
TBC/RABGAPs	42	6.63e-02	0.164000	3.41e-01
Signaling by FLT3 ITD and TKD mutants	16	2.59e-01	-0.163000	6.52e-01
Vpu mediated degradation of CD4	50	4.62e-02	0.163000	2.92e-01
SARS-CoV-1 Infection	134	1.13e-03	0.163000	2.70e-02
Cyclin D associated events in G1	46	5.62e-02	0.163000	3.21e-01
G1 Phase	46	5.62e-02	0.163000	3.21e-01
NIK–>noncanonical NF-kB signaling	57	3.37e-02	0.163000	2.47e-01
Nucleotide biosynthesis	14	2.93e-01	0.162000	6.88e-01
Signaling by FGFR4	40	7.64e-02	0.162000	3.63e-01
Activation of the AP-1 family of transcription factors	10	3.75e-01	0.162000	7.42e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	13	3.13e-01	-0.162000	7.01e-01
Activation of BAD and translocation to mitochondria	15	2.80e-01	0.161000	6.80e-01
Budding and maturation of HIV virion	28	1.40e-01	0.161000	4.88e-01
FGFR4 ligand binding and activation	13	3.15e-01	0.161000	7.02e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	110	3.68e-03	-0.160000	6.19e-02
Synaptic adhesion-like molecules	19	2.27e-01	0.160000	6.15e-01
Termination of translesion DNA synthesis	31	1.23e-01	0.160000	4.57e-01
Activated point mutants of FGFR2	16	2.69e-01	0.160000	6.65e-01
Signaling by FGFR	85	1.12e-02	0.159000	1.31e-01
Amino acids regulate mTORC1	52	4.75e-02	0.159000	2.94e-01
Condensation of Prometaphase Chromosomes	11	3.62e-01	0.159000	7.41e-01
IRF3-mediated induction of type I IFN	11	3.63e-01	-0.158000	7.41e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	5.80e-02	0.158000	3.23e-01
Regulation of RUNX3 expression and activity	53	4.66e-02	0.158000	2.92e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	5.34e-02	0.158000	3.13e-01
p53-Independent DNA Damage Response	50	5.34e-02	0.158000	3.13e-01
p53-Independent G1/S DNA damage checkpoint	50	5.34e-02	0.158000	3.13e-01
Signaling by FGFR2 IIIa TM	19	2.34e-01	0.158000	6.22e-01
mRNA Splicing - Major Pathway	174	3.33e-04	0.158000	9.70e-03
Metabolism of fat-soluble vitamins	46	6.56e-02	0.157000	3.41e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	1.97e-02	0.157000	1.80e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	2.64e-01	0.157000	6.59e-01
Advanced glycosylation endproduct receptor signaling	13	3.31e-01	0.156000	7.19e-01
Antimicrobial peptides	78	1.75e-02	-0.156000	1.69e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	3.96e-01	0.155000	7.60e-01
Negative regulation of NOTCH4 signaling	52	5.35e-02	0.155000	3.13e-01
Regulation of TNFR1 signaling	37	1.03e-01	0.155000	4.17e-01
TP53 Regulates Transcription of Cell Cycle Genes	49	6.14e-02	0.154000	3.32e-01
G beta:gamma signalling through BTK	17	2.72e-01	-0.154000	6.68e-01
Initial triggering of complement	21	2.22e-01	0.154000	6.11e-01
Metabolism of RNA	639	3.41e-11	0.153000	7.53e-09
Transcriptional regulation of testis differentiation	12	3.59e-01	-0.153000	7.41e-01
PINK1-PRKN Mediated Mitophagy	21	2.25e-01	0.153000	6.14e-01
Synthesis of substrates in N-glycan biosythesis	60	4.16e-02	0.152000	2.80e-01
MicroRNA (miRNA) biogenesis	26	1.81e-01	0.152000	5.56e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	3.09e-01	0.152000	6.98e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	1.74e-01	0.151000	5.46e-01
APC/C-mediated degradation of cell cycle proteins	86	1.54e-02	0.151000	1.55e-01
Regulation of mitotic cell cycle	86	1.54e-02	0.151000	1.55e-01
FGFR2 alternative splicing	26	1.82e-01	0.151000	5.56e-01
Metabolism of amino acids and derivatives	344	1.47e-06	0.151000	7.58e-05
Signaling by NOTCH2	32	1.41e-01	0.150000	4.88e-01
Xenobiotics	24	2.02e-01	-0.150000	5.88e-01
Signaling by NOTCH4	79	2.11e-02	0.150000	1.84e-01
Receptor Mediated Mitophagy	10	4.12e-01	0.150000	7.72e-01
MTOR signalling	40	1.01e-01	0.150000	4.17e-01
Striated Muscle Contraction	33	1.37e-01	0.150000	4.82e-01
Initiation of Nuclear Envelope (NE) Reformation	18	2.73e-01	0.149000	6.68e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	87	1.62e-02	0.149000	1.61e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	2.88e-01	0.149000	6.86e-01
Processing of Capped Intron-Containing Pre-mRNA	232	9.30e-05	0.149000	2.88e-03
Glutathione synthesis and recycling	12	3.73e-01	0.148000	7.41e-01
Cyclin E associated events during G1/S transition	81	2.14e-02	0.148000	1.86e-01
ABC transporters in lipid homeostasis	17	2.92e-01	0.148000	6.88e-01
Organic anion transporters	10	4.20e-01	0.147000	7.73e-01
Cyclin A:Cdk2-associated events at S phase entry	83	2.04e-02	0.147000	1.82e-01
Metabolism of Angiotensinogen to Angiotensins	15	3.25e-01	-0.147000	7.15e-01
Signaling by FGFR2 in disease	42	1.00e-01	0.147000	4.17e-01
Transport of vitamins, nucleosides, and related molecules	38	1.18e-01	0.146000	4.52e-01
Heme degradation	16	3.11e-01	-0.146000	6.98e-01
Interleukin-37 signaling	20	2.57e-01	-0.146000	6.52e-01
Transcriptional Regulation by MECP2	60	4.99e-02	-0.146000	3.05e-01
Triglyceride metabolism	36	1.31e-01	-0.146000	4.72e-01
DNA Damage Bypass	46	8.86e-02	0.145000	3.95e-01
Dectin-2 family	28	1.84e-01	-0.145000	5.60e-01
Reactions specific to the complex N-glycan synthesis pathway	10	4.28e-01	-0.145000	7.73e-01
Stabilization of p53	55	6.34e-02	0.145000	3.35e-01
Telomere Maintenance	62	4.89e-02	0.145000	3.01e-01
Regulation of TP53 Activity through Methylation	18	2.88e-01	0.145000	6.86e-01
Laminin interactions	23	2.32e-01	0.144000	6.18e-01
Metabolism of polyamines	55	6.48e-02	0.144000	3.41e-01
Negative epigenetic regulation of rRNA expression	45	9.49e-02	0.144000	4.06e-01
Signaling by FGFR2	72	3.48e-02	0.144000	2.52e-01
Plasma lipoprotein assembly, remodeling, and clearance	73	3.36e-02	0.144000	2.47e-01
Signaling by Activin	15	3.35e-01	0.144000	7.21e-01
Signaling by FGFR3	39	1.21e-01	0.144000	4.55e-01
TICAM1, RIP1-mediated IKK complex recruitment	18	2.92e-01	0.143000	6.88e-01
Global Genome Nucleotide Excision Repair (GG-NER)	81	2.57e-02	0.143000	2.10e-01
Attachment and Entry 9694614	16	3.24e-01	0.142000	7.15e-01
RHO GTPases Activate ROCKs	19	2.83e-01	0.142000	6.84e-01
NoRC negatively regulates rRNA expression	43	1.08e-01	0.142000	4.26e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	3.62e-01	0.141000	7.41e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	38	1.34e-01	-0.140000	4.80e-01
Interleukin-7 signaling	21	2.67e-01	-0.140000	6.63e-01
SHC1 events in ERBB2 signaling	22	2.56e-01	-0.140000	6.52e-01
Activation of NF-kappaB in B cells	64	5.31e-02	0.140000	3.13e-01
HS-GAG degradation	18	3.06e-01	0.139000	6.97e-01
Regulation of ornithine decarboxylase (ODC)	49	9.15e-02	0.139000	3.99e-01
FGFR1c ligand binding and activation	11	4.24e-01	0.139000	7.73e-01
Signaling by activated point mutants of FGFR1	11	4.24e-01	0.139000	7.73e-01
PI3K events in ERBB2 signaling	16	3.35e-01	-0.139000	7.21e-01
Acetylcholine regulates insulin secretion	10	4.48e-01	-0.139000	7.74e-01
Heme signaling	45	1.09e-01	-0.138000	4.27e-01
Receptor-type tyrosine-protein phosphatases	16	3.39e-01	0.138000	7.24e-01
Interleukin-35 Signalling	12	4.08e-01	-0.138000	7.70e-01
Plasma lipoprotein clearance	37	1.48e-01	0.137000	4.96e-01
InlB-mediated entry of Listeria monocytogenes into host cell	14	3.74e-01	0.137000	7.41e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	49	9.71e-02	0.137000	4.11e-01
RNA Polymerase I Transcription Initiation	42	1.25e-01	0.137000	4.59e-01
Homology Directed Repair	99	1.88e-02	0.137000	1.76e-01
Erythrocytes take up carbon dioxide and release oxygen	12	4.13e-01	0.136000	7.72e-01
O2/CO2 exchange in erythrocytes	12	4.13e-01	0.136000	7.72e-01
Scavenging by Class A Receptors	19	3.04e-01	-0.136000	6.97e-01
FGFR1 mutant receptor activation	30	1.97e-01	-0.136000	5.81e-01
Regulation of TP53 Degradation	36	1.58e-01	0.136000	5.16e-01
Citric acid cycle (TCA cycle)	21	2.81e-01	0.136000	6.80e-01
Maturation of spike protein 9694548	35	1.65e-01	-0.136000	5.32e-01
Glycogen synthesis	13	3.98e-01	0.135000	7.60e-01
Plasma lipoprotein assembly	19	3.07e-01	0.135000	6.98e-01
RNA Polymerase II Transcription Termination	62	6.69e-02	0.135000	3.41e-01
Reversible hydration of carbon dioxide	11	4.40e-01	-0.134000	7.73e-01
Insulin receptor recycling	26	2.36e-01	0.134000	6.25e-01
Crosslinking of collagen fibrils	10	4.62e-01	0.134000	7.79e-01
Assembly of the pre-replicative complex	82	3.56e-02	0.134000	2.54e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	3.00e-01	0.134000	6.95e-01
RORA activates gene expression	17	3.40e-01	-0.134000	7.24e-01
Cleavage of the damaged purine	11	4.43e-01	-0.134000	7.73e-01
Depurination	11	4.43e-01	-0.134000	7.73e-01
Recognition and association of DNA glycosylase with site containing an affected purine	11	4.43e-01	-0.134000	7.73e-01
Phosphorylation of CD3 and TCR zeta chains	20	3.01e-01	-0.134000	6.95e-01
Regulation of RAS by GAPs	65	6.32e-02	0.133000	3.35e-01
G alpha (i) signalling events	305	6.24e-05	-0.133000	2.03e-03
Regulation of gene expression by Hypoxia-inducible Factor	11	4.45e-01	0.133000	7.74e-01
Unfolded Protein Response (UPR)	90	2.94e-02	0.133000	2.33e-01
Insulin processing	26	2.42e-01	-0.133000	6.33e-01
Ribavirin ADME	11	4.46e-01	0.133000	7.74e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	9.22e-02	0.132000	3.99e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	9.22e-02	0.132000	3.99e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	9.22e-02	0.132000	3.99e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	9.22e-02	0.132000	3.99e-01
Signaling by NOTCH1 in Cancer	54	9.22e-02	0.132000	3.99e-01
Signaling by ERBB2 ECD mutants	15	3.75e-01	0.132000	7.42e-01
Suppression of phagosomal maturation	13	4.09e-01	0.132000	7.71e-01
eNOS activation	11	4.48e-01	0.132000	7.74e-01
G beta:gamma signalling through PLC beta	20	3.07e-01	-0.132000	6.97e-01
MET activates RAP1 and RAC1	11	4.49e-01	-0.132000	7.74e-01
Degradation of DVL	55	9.07e-02	0.132000	3.99e-01
Translesion synthesis by REV1	16	3.62e-01	0.132000	7.41e-01
FCERI mediated Ca+2 mobilization	27	2.37e-01	-0.131000	6.26e-01
SHC-mediated cascade:FGFR2	22	2.86e-01	0.131000	6.86e-01
Diseases of carbohydrate metabolism	30	2.13e-01	0.131000	6.02e-01
Defective B4GALT7 causes EDS, progeroid type	17	3.49e-01	0.131000	7.33e-01
Regulation of pyruvate dehydrogenase (PDH) complex	14	3.96e-01	0.131000	7.60e-01
Switching of origins to a post-replicative state	90	3.15e-02	0.131000	2.37e-01
Purine salvage	12	4.32e-01	0.131000	7.73e-01
RNA Polymerase III Abortive And Retractive Initiation	41	1.47e-01	0.131000	4.94e-01
RNA Polymerase III Transcription	41	1.47e-01	0.131000	4.94e-01
Cytosolic sensors of pathogen-associated DNA	60	7.96e-02	0.131000	3.70e-01
Scavenging of heme from plasma	12	4.33e-01	-0.131000	7.73e-01
TNF signaling	45	1.30e-01	0.131000	4.70e-01
Downregulation of ERBB2 signaling	28	2.32e-01	0.130000	6.18e-01
mRNA 3’-end processing	53	1.00e-01	0.130000	4.17e-01
DNA Replication	125	1.17e-02	0.130000	1.35e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	16	3.68e-01	0.130000	7.41e-01
Synthesis of DNA	118	1.46e-02	0.130000	1.53e-01
Glyoxylate metabolism and glycine degradation	30	2.18e-01	0.130000	6.09e-01
Processing of DNA double-strand break ends	61	7.92e-02	0.130000	3.70e-01
A tetrasaccharide linker sequence is required for GAG synthesis	23	2.81e-01	0.130000	6.80e-01
G beta:gamma signalling through CDC42	19	3.29e-01	-0.129000	7.17e-01
Intra-Golgi traffic	43	1.43e-01	-0.129000	4.92e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	1.04e-01	0.129000	4.20e-01
Signaling by high-kinase activity BRAF mutants	32	2.07e-01	-0.129000	5.95e-01
HDR through Homologous Recombination (HRR)	64	7.44e-02	0.129000	3.58e-01
Regulation of NPAS4 gene expression	13	4.21e-01	0.129000	7.73e-01
Maturation of nucleoprotein 9683610	11	4.61e-01	0.128000	7.79e-01
Vif-mediated degradation of APOBEC3G	50	1.18e-01	0.128000	4.52e-01
SHC-mediated cascade:FGFR4	19	3.35e-01	0.128000	7.21e-01
SHC1 events in ERBB4 signaling	14	4.10e-01	-0.127000	7.71e-01
Early Phase of HIV Life Cycle	14	4.10e-01	0.127000	7.71e-01
Adherens junctions interactions	26	2.63e-01	-0.127000	6.58e-01
Sulfur amino acid metabolism	27	2.55e-01	0.127000	6.52e-01
ADP signalling through P2Y purinoceptor 12	22	3.06e-01	-0.126000	6.97e-01
Molecules associated with elastic fibres	29	2.41e-01	0.126000	6.31e-01
Resolution of Abasic Sites (AP sites)	37	1.86e-01	0.126000	5.61e-01
Detoxification of Reactive Oxygen Species	35	1.98e-01	0.126000	5.83e-01
DCC mediated attractive signaling	14	4.15e-01	-0.126000	7.73e-01
Interleukin receptor SHC signaling	24	2.87e-01	-0.125000	6.86e-01
Mitophagy	27	2.59e-01	0.125000	6.52e-01
Signal attenuation	10	4.94e-01	0.125000	8.07e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	15	4.02e-01	-0.125000	7.64e-01
Phase 2 - plateau phase	14	4.18e-01	0.125000	7.73e-01
Phospholipase C-mediated cascade; FGFR3	12	4.54e-01	0.125000	7.78e-01
Uptake and actions of bacterial toxins	29	2.45e-01	0.125000	6.37e-01
Dual Incision in GG-NER	39	1.78e-01	0.125000	5.54e-01
Elastic fibre formation	40	1.74e-01	0.124000	5.46e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	93	3.84e-02	0.124000	2.67e-01
DNA Double Strand Break Response	42	1.66e-01	0.124000	5.32e-01
Frs2-mediated activation	12	4.60e-01	0.123000	7.79e-01
Signalling to ERKs	34	2.14e-01	0.123000	6.02e-01
VEGFR2 mediated cell proliferation	19	3.54e-01	0.123000	7.39e-01
Defective B3GAT3 causes JDSSDHD	17	3.82e-01	0.123000	7.45e-01
Sodium/Calcium exchangers	11	4.82e-01	-0.122000	7.98e-01
Epigenetic regulation of gene expression	83	5.43e-02	0.122000	3.16e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	3.98e-01	0.122000	7.60e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	1.35e-01	0.122000	4.81e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	4.86e-01	-0.121000	8.00e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	2.96e-01	0.121000	6.88e-01
RNA polymerase II transcribes snRNA genes	77	6.72e-02	0.121000	3.41e-01
ERK/MAPK targets	20	3.52e-01	0.120000	7.37e-01
Transport of Ribonucleoproteins into the Host Nucleus	30	2.55e-01	-0.120000	6.52e-01
Cross-presentation of soluble exogenous antigens (endosomes)	46	1.60e-01	0.120000	5.21e-01
Translation of Structural Proteins 9683701	29	2.65e-01	0.120000	6.61e-01
Regulation of Apoptosis	51	1.41e-01	0.119000	4.88e-01
FGFR2c ligand binding and activation	12	4.75e-01	0.119000	7.93e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	5.14e-01	0.119000	8.11e-01
Downstream signaling events of B Cell Receptor (BCR)	78	6.92e-02	0.119000	3.46e-01
Passive transport by Aquaporins	13	4.59e-01	0.119000	7.79e-01
DNA Double-Strand Break Repair	129	1.99e-02	0.119000	1.80e-01
Regulation of TP53 Activity through Phosphorylation	88	5.49e-02	0.118000	3.17e-01
Class I peroxisomal membrane protein import	19	3.72e-01	0.118000	7.41e-01
BBSome-mediated cargo-targeting to cilium	23	3.26e-01	-0.118000	7.16e-01
RAC1 GTPase cycle	170	7.82e-03	-0.118000	1.02e-01
UCH proteinases	81	6.67e-02	0.118000	3.41e-01
Interactions of Vpr with host cellular proteins	33	2.45e-01	-0.117000	6.36e-01
ERBB2 Regulates Cell Motility	15	4.33e-01	-0.117000	7.73e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	3.66e-01	0.117000	7.41e-01
Regulation of TP53 Expression and Degradation	37	2.19e-01	0.117000	6.09e-01
Generation of second messenger molecules	30	2.70e-01	-0.116000	6.68e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	3.14e-01	0.116000	7.01e-01
Activation of the TFAP2 (AP-2) family of transcription factors	11	5.04e-01	0.116000	8.08e-01
Metabolism of nucleotides	95	5.02e-02	0.116000	3.05e-01
Downregulation of TGF-beta receptor signaling	26	3.05e-01	0.116000	6.97e-01
Defective pyroptosis	11	5.05e-01	-0.116000	8.08e-01
HIV Life Cycle	139	1.80e-02	0.116000	1.73e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	41	1.99e-01	0.116000	5.85e-01
Erythropoietin activates RAS	14	4.53e-01	0.116000	7.78e-01
NCAM1 interactions	36	2.29e-01	0.116000	6.18e-01
NS1 Mediated Effects on Host Pathways	39	2.11e-01	-0.116000	5.99e-01
PIWI-interacting RNA (piRNA) biogenesis	29	2.81e-01	0.116000	6.80e-01
Processive synthesis on the lagging strand	14	4.54e-01	0.116000	7.78e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	95	5.20e-02	0.115000	3.13e-01
DNA Replication Pre-Initiation	97	4.96e-02	0.115000	3.04e-01
Gap junction degradation	10	5.29e-01	-0.115000	8.19e-01
HIV Transcription Initiation	43	1.92e-01	0.115000	5.70e-01
RNA Polymerase II HIV Promoter Escape	43	1.92e-01	0.115000	5.70e-01
RNA Polymerase II Promoter Escape	43	1.92e-01	0.115000	5.70e-01
RNA Polymerase II Transcription Initiation	43	1.92e-01	0.115000	5.70e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	1.92e-01	0.115000	5.70e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	1.92e-01	0.115000	5.70e-01
Late Phase of HIV Life Cycle	126	2.58e-02	0.115000	2.10e-01
IL-6-type cytokine receptor ligand interactions	17	4.12e-01	0.115000	7.72e-01
MyD88 cascade initiated on plasma membrane	91	5.80e-02	0.115000	3.23e-01
Toll Like Receptor 10 (TLR10) Cascade	91	5.80e-02	0.115000	3.23e-01
Toll Like Receptor 5 (TLR5) Cascade	91	5.80e-02	0.115000	3.23e-01
Keratan sulfate/keratin metabolism	33	2.54e-01	-0.115000	6.51e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	4.42e-01	0.115000	7.73e-01
PCNA-Dependent Long Patch Base Excision Repair	21	3.65e-01	0.114000	7.41e-01
Meiotic recombination	26	3.15e-01	-0.114000	7.02e-01
Trafficking and processing of endosomal TLR	11	5.14e-01	0.114000	8.11e-01
RNA Polymerase III Transcription Initiation	36	2.38e-01	0.114000	6.27e-01
TGF-beta receptor signaling activates SMADs	45	1.89e-01	0.113000	5.69e-01
Iron uptake and transport	57	1.40e-01	0.113000	4.88e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14	4.64e-01	-0.113000	7.80e-01
Cellular response to heat stress	95	5.72e-02	0.113000	3.23e-01
Retrograde transport at the Trans-Golgi-Network	47	1.81e-01	-0.113000	5.56e-01
Regulation of MECP2 expression and activity	30	2.86e-01	-0.113000	6.86e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	2.95e-01	-0.112000	6.88e-01
Nitric oxide stimulates guanylate cyclase	22	3.62e-01	-0.112000	7.41e-01
Asymmetric localization of PCP proteins	62	1.26e-01	0.112000	4.60e-01
Translesion synthesis by POLK	17	4.24e-01	0.112000	7.73e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	3.06e-01	0.112000	6.97e-01
Degradation of GLI2 by the proteasome	58	1.51e-01	0.109000	5.01e-01
FCERI mediated NF-kB activation	74	1.05e-01	0.109000	4.22e-01
G2/M Checkpoints	129	3.25e-02	0.109000	2.43e-01
Cell Cycle Checkpoints	248	3.10e-03	0.109000	5.64e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	4.38e-01	0.109000	7.73e-01
Formation of Incision Complex in GG-NER	40	2.36e-01	0.108000	6.25e-01
Prolonged ERK activation events	14	4.83e-01	0.108000	7.98e-01
Chromosome Maintenance	86	8.31e-02	0.108000	3.84e-01
Signaling by FGFR1 in disease	37	2.57e-01	-0.108000	6.52e-01
Activation of AMPK downstream of NMDARs	10	5.57e-01	0.107000	8.34e-01
GRB2 events in ERBB2 signaling	16	4.58e-01	-0.107000	7.79e-01
Cellular responses to stress	682	1.79e-06	0.107000	8.93e-05
FGFR2 ligand binding and activation	19	4.21e-01	0.107000	7.73e-01
MAPK6/MAPK4 signaling	89	8.25e-02	0.106000	3.82e-01
Metabolic disorders of biological oxidation enzymes	32	2.98e-01	0.106000	6.92e-01
G0 and Early G1	27	3.41e-01	0.106000	7.24e-01
Leading Strand Synthesis	13	5.10e-01	0.106000	8.10e-01
Polymerase switching	13	5.10e-01	0.106000	8.10e-01
Separation of Sister Chromatids	161	2.11e-02	0.105000	1.84e-01
Glycogen metabolism	22	3.94e-01	0.105000	7.60e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	1.82e-01	0.105000	5.56e-01
G-protein activation	24	3.76e-01	-0.104000	7.42e-01
Syndecan interactions	19	4.31e-01	0.104000	7.73e-01
Signalling to RAS	20	4.20e-01	0.104000	7.73e-01
Cellular responses to stimuli	696	2.69e-06	0.104000	1.30e-04
Estrogen-dependent gene expression	91	8.62e-02	0.104000	3.91e-01
FOXO-mediated transcription	65	1.47e-01	0.104000	4.94e-01
Phase 0 - rapid depolarisation	31	3.18e-01	0.104000	7.04e-01
Adenylate cyclase inhibitory pathway	14	5.02e-01	0.104000	8.08e-01
MET receptor recycling	10	5.71e-01	0.104000	8.40e-01
Interleukin-1 signaling	109	6.19e-02	0.103000	3.32e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	2.02e-01	0.103000	5.88e-01
Binding and Uptake of Ligands by Scavenger Receptors	41	2.53e-01	-0.103000	6.51e-01
G beta:gamma signalling through PI3Kgamma	25	3.73e-01	-0.103000	7.41e-01
EGFR downregulation	30	3.29e-01	0.103000	7.18e-01
FGFR3 mutant receptor activation	11	5.55e-01	0.103000	8.33e-01
Signaling by activated point mutants of FGFR3	11	5.55e-01	0.103000	8.33e-01
CD28 dependent Vav1 pathway	11	5.55e-01	-0.103000	8.33e-01
PTEN Regulation	150	2.98e-02	0.103000	2.34e-01
Muscle contraction	193	1.39e-02	0.103000	1.50e-01
Oncogene Induced Senescence	35	2.94e-01	0.102000	6.88e-01
Depolymerisation of the Nuclear Lamina	14	5.07e-01	0.102000	8.08e-01
Cellular response to hypoxia	71	1.35e-01	0.102000	4.81e-01
Cell surface interactions at the vascular wall	127	4.76e-02	-0.102000	2.94e-01
FGFR3 ligand binding and activation	12	5.43e-01	0.101000	8.28e-01
FGFR3c ligand binding and activation	12	5.43e-01	0.101000	8.28e-01
Degradation of AXIN	53	2.02e-01	0.101000	5.88e-01
Acyl chain remodelling of PI	16	4.83e-01	0.101000	7.98e-01
Signaling by PDGFR in disease	20	4.34e-01	-0.101000	7.73e-01
Acyl chain remodelling of PC	26	3.74e-01	0.101000	7.41e-01
Transferrin endocytosis and recycling	30	3.41e-01	0.100000	7.24e-01
CLEC7A (Dectin-1) signaling	96	8.94e-02	0.100000	3.97e-01
ADP signalling through P2Y purinoceptor 1	25	3.86e-01	-0.100000	7.50e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	5.02e-01	0.100000	8.08e-01
Amino acid transport across the plasma membrane	30	3.43e-01	0.100000	7.26e-01
VxPx cargo-targeting to cilium	20	4.39e-01	0.099900	7.73e-01
TRP channels	24	3.98e-01	0.099600	7.60e-01
Peptide hormone metabolism	83	1.17e-01	-0.099500	4.51e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	3.46e-01	-0.099500	7.27e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	3.46e-01	-0.099500	7.27e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	68	1.56e-01	0.099500	5.12e-01
Signaling by TGF-beta Receptor Complex	90	1.03e-01	0.099400	4.17e-01
Presynaptic depolarization and calcium channel opening	12	5.51e-01	0.099400	8.33e-01
S Phase	157	3.16e-02	0.099300	2.37e-01
Cytosolic sulfonation of small molecules	21	4.32e-01	0.099100	7.73e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	5.52e-01	-0.099000	8.33e-01
TP53 Regulates Metabolic Genes	83	1.19e-01	0.098900	4.53e-01
FOXO-mediated transcription of cell death genes	15	5.09e-01	0.098500	8.10e-01
FOXO-mediated transcription of cell cycle genes	16	4.96e-01	0.098400	8.07e-01
Respiratory electron transport	90	1.07e-01	0.098200	4.26e-01
Myogenesis	29	3.60e-01	-0.098200	7.41e-01
Smooth Muscle Contraction	43	2.66e-01	0.097900	6.63e-01
Nuclear events mediated by NFE2L2	76	1.41e-01	0.097700	4.88e-01
G1/S Transition	126	5.82e-02	0.097700	3.23e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	62	1.83e-01	0.097700	5.58e-01
Inflammasomes	21	4.39e-01	-0.097500	7.73e-01
Vpr-mediated nuclear import of PICs	32	3.40e-01	-0.097400	7.24e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	75	1.45e-01	-0.097300	4.94e-01
HIV Infection	216	1.36e-02	0.097300	1.49e-01
Tryptophan catabolism	12	5.60e-01	-0.097300	8.36e-01
COPII-mediated vesicle transport	66	1.73e-01	0.097000	5.46e-01
Signaling by ALK fusions and activated point mutants	51	2.31e-01	-0.097000	6.18e-01
Signaling by ALK in cancer	51	2.31e-01	-0.097000	6.18e-01
Energy dependent regulation of mTOR by LKB1-AMPK	28	3.75e-01	0.096800	7.42e-01
RUNX2 regulates osteoblast differentiation	22	4.33e-01	0.096600	7.73e-01
Activation of kainate receptors upon glutamate binding	29	3.69e-01	-0.096400	7.41e-01
Transcriptional regulation by RUNX3	93	1.08e-01	0.096400	4.26e-01
Degradation of GLI1 by the proteasome	58	2.06e-01	0.096100	5.94e-01
DNA Repair	276	6.08e-03	0.095900	8.46e-02
ERBB2 Activates PTK6 Signaling	13	5.50e-01	-0.095800	8.33e-01
SUMOylation of intracellular receptors	29	3.72e-01	-0.095700	7.41e-01
RHOJ GTPase cycle	51	2.37e-01	-0.095700	6.26e-01
Surfactant metabolism	28	3.81e-01	0.095600	7.45e-01
Presynaptic function of Kainate receptors	21	4.49e-01	-0.095500	7.74e-01
Cell-cell junction organization	56	2.16e-01	-0.095500	6.06e-01
Downstream signaling of activated FGFR1	31	3.58e-01	0.095300	7.41e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	3.83e-01	-0.095200	7.47e-01
Deadenylation of mRNA	25	4.10e-01	-0.095100	7.71e-01
LDL clearance	19	4.75e-01	0.094700	7.93e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	5.01e-01	-0.094200	8.08e-01
SUMOylation of DNA damage response and repair proteins	71	1.71e-01	-0.094000	5.44e-01
Regulation of HSF1-mediated heat shock response	78	1.51e-01	0.094000	5.01e-01
Constitutive Signaling by EGFRvIII	15	5.30e-01	0.093600	8.19e-01
Signaling by EGFRvIII in Cancer	15	5.30e-01	0.093600	8.19e-01
Association of TriC/CCT with target proteins during biosynthesis	38	3.19e-01	-0.093500	7.06e-01
O-glycosylation of TSR domain-containing proteins	37	3.26e-01	0.093400	7.15e-01
Late endosomal microautophagy	32	3.62e-01	0.093200	7.41e-01
Regulation of Complement cascade	45	2.80e-01	-0.093100	6.80e-01
Mitotic G1 phase and G1/S transition	144	5.38e-02	0.093000	3.14e-01
TNFs bind their physiological receptors	25	4.21e-01	-0.093000	7.73e-01
Mitotic Spindle Checkpoint	106	9.80e-02	0.093000	4.14e-01
Mitotic Metaphase and Anaphase	222	1.69e-02	0.092900	1.67e-01
Protein methylation	16	5.20e-01	0.092900	8.11e-01
NCAM signaling for neurite out-growth	57	2.25e-01	0.092800	6.14e-01
GLI3 is processed to GLI3R by the proteasome	58	2.21e-01	0.092800	6.11e-01
SARS-CoV-2 modulates autophagy	11	5.94e-01	-0.092800	8.58e-01
Germ layer formation at gastrulation	16	5.22e-01	-0.092500	8.12e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	23	4.42e-01	0.092500	7.73e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	23	4.42e-01	0.092500	7.73e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	23	4.42e-01	0.092500	7.73e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	23	4.42e-01	0.092500	7.73e-01
Impaired BRCA2 binding to PALB2	23	4.42e-01	0.092500	7.73e-01
Non-integrin membrane-ECM interactions	40	3.11e-01	0.092500	6.99e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	42	3.00e-01	-0.092400	6.95e-01
Signaling by BRAF and RAF1 fusions	60	2.16e-01	-0.092400	6.05e-01
Formation of tubulin folding intermediates by CCT/TriC	26	4.15e-01	-0.092300	7.73e-01
NEP/NS2 Interacts with the Cellular Export Machinery	30	3.82e-01	-0.092300	7.45e-01
Regulation of RUNX2 expression and activity	71	1.79e-01	0.092100	5.56e-01
Butyrophilin (BTN) family interactions	12	5.81e-01	-0.092000	8.49e-01
RAC2 GTPase cycle	80	1.56e-01	-0.091800	5.12e-01
DAG and IP3 signaling	39	3.22e-01	-0.091600	7.12e-01
Neddylation	228	1.72e-02	0.091500	1.68e-01
Regulation of TP53 Activity through Acetylation	29	3.94e-01	0.091500	7.60e-01
Disorders of transmembrane transporters	167	4.23e-02	0.091000	2.82e-01
ABC-family proteins mediated transport	98	1.20e-01	0.090900	4.53e-01
RHOG GTPase cycle	69	1.92e-01	-0.090800	5.70e-01
Thromboxane signalling through TP receptor	24	4.41e-01	-0.090800	7.73e-01
CDC42 GTPase cycle	143	6.09e-02	-0.090700	3.30e-01
Ca-dependent events	35	3.54e-01	-0.090600	7.39e-01
Drug ADME	104	1.11e-01	-0.090400	4.33e-01
Transcriptional regulation by RUNX2	116	9.28e-02	0.090300	4.01e-01
Mitotic Anaphase	221	2.08e-02	0.090200	1.84e-01
Nuclear Events (kinase and transcription factor activation)	60	2.27e-01	0.090100	6.15e-01
Cytochrome c-mediated apoptotic response	12	5.89e-01	-0.090100	8.55e-01
Killing mechanisms	11	6.05e-01	0.090000	8.64e-01
WNT5:FZD7-mediated leishmania damping	11	6.05e-01	0.090000	8.64e-01
Uptake and function of anthrax toxins	11	6.06e-01	-0.089900	8.64e-01
PI-3K cascade:FGFR1	21	4.76e-01	0.089800	7.94e-01
RHO GTPases activate KTN1	11	6.06e-01	0.089800	8.64e-01
Orc1 removal from chromatin	69	1.98e-01	0.089600	5.83e-01
Signaling by SCF-KIT	43	3.11e-01	-0.089300	6.98e-01
Lysosome Vesicle Biogenesis	33	3.76e-01	0.089100	7.42e-01
Axon guidance	503	6.34e-04	0.088800	1.75e-02
Cell recruitment (pro-inflammatory response)	25	4.42e-01	-0.088800	7.73e-01
Purinergic signaling in leishmaniasis infection	25	4.42e-01	-0.088800	7.73e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	6.11e-01	-0.088600	8.67e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	5.97e-01	-0.088200	8.61e-01
Prostacyclin signalling through prostacyclin receptor	19	5.06e-01	-0.088100	8.08e-01
Branched-chain amino acid catabolism	20	4.95e-01	0.088100	8.07e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	5.68e-01	0.088100	8.39e-01
EPH-ephrin mediated repulsion of cells	48	2.92e-01	0.087800	6.88e-01
Signaling by Non-Receptor Tyrosine Kinases	55	2.60e-01	0.087800	6.52e-01
Signaling by PTK6	55	2.60e-01	0.087800	6.52e-01
FRS-mediated FGFR1 signaling	23	4.66e-01	0.087700	7.83e-01
Regulation of PTEN gene transcription	59	2.44e-01	0.087600	6.36e-01
Regulation of TP53 Activity through Association with Co-factors	14	5.71e-01	0.087400	8.40e-01
PLC beta mediated events	47	3.01e-01	-0.087300	6.95e-01
Cardiac conduction	123	9.49e-02	0.087200	4.06e-01
G2/M DNA damage checkpoint	58	2.51e-01	0.087100	6.49e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	3.34e-01	-0.087100	7.21e-01
SHC1 events in EGFR signaling	14	5.74e-01	0.086800	8.43e-01
Voltage gated Potassium channels	42	3.31e-01	0.086700	7.19e-01
TNFR2 non-canonical NF-kB pathway	94	1.47e-01	0.086500	4.94e-01
Azathioprine ADME	22	4.83e-01	0.086400	7.98e-01
CLEC7A (Dectin-1) induces NFAT activation	11	6.20e-01	-0.086300	8.71e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	14	5.76e-01	-0.086300	8.45e-01
SHC-mediated cascade:FGFR3	17	5.38e-01	0.086200	8.25e-01
Homologous DNA Pairing and Strand Exchange	41	3.40e-01	0.086200	7.24e-01
GPCR ligand binding	443	1.84e-03	-0.086200	3.85e-02
Maturation of nucleoprotein 9694631	15	5.64e-01	0.086100	8.36e-01
mRNA decay by 3’ to 5’ exoribonuclease	16	5.52e-01	0.085900	8.33e-01
RIPK1-mediated regulated necrosis	27	4.40e-01	0.085900	7.73e-01
Regulation of necroptotic cell death	27	4.40e-01	0.085900	7.73e-01
Hedgehog ‘on’ state	83	1.77e-01	0.085800	5.49e-01
The citric acid (TCA) cycle and respiratory electron transport	143	7.67e-02	0.085700	3.63e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	5.41e-01	0.085700	8.26e-01
RHO GTPases activate PAKs	19	5.18e-01	0.085700	8.11e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	5.66e-01	0.085600	8.37e-01
WNT ligand biogenesis and trafficking	25	4.59e-01	0.085500	7.79e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	5.94e-01	0.085500	8.58e-01
Synthesis of IP3 and IP4 in the cytosol	25	4.62e-01	0.085000	7.79e-01
RHOQ GTPase cycle	57	2.67e-01	-0.085000	6.63e-01
Netrin-1 signaling	49	3.04e-01	-0.084900	6.97e-01
Nervous system development	527	8.82e-04	0.084500	2.26e-02
Acyl chain remodelling of PS	21	5.04e-01	0.084300	8.08e-01
RHO GTPases Activate Formins	114	1.21e-01	0.084000	4.56e-01
RHOBTB1 GTPase cycle	22	4.96e-01	-0.083900	8.07e-01
Glycerophospholipid biosynthesis	114	1.23e-01	0.083600	4.56e-01
GRB2 events in EGFR signaling	13	6.02e-01	0.083600	8.64e-01
RHOBTB2 GTPase cycle	22	4.98e-01	-0.083500	8.07e-01
FLT3 signaling in disease	28	4.45e-01	-0.083300	7.74e-01
Potassium Channels	102	1.46e-01	0.083200	4.94e-01
RIP-mediated NFkB activation via ZBP1	16	5.66e-01	0.083000	8.37e-01
Transcriptional Regulation by TP53	346	8.00e-03	0.082900	1.03e-01
Metabolism of cofactors	19	5.32e-01	0.082800	8.19e-01
Macroautophagy	111	1.32e-01	0.082700	4.75e-01
MyD88 dependent cascade initiated on endosome	96	1.62e-01	0.082500	5.26e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	96	1.62e-01	0.082500	5.26e-01
Complement cascade	56	2.87e-01	-0.082300	6.86e-01
Ion transport by P-type ATPases	51	3.09e-01	-0.082300	6.98e-01
Transport of bile salts and organic acids, metal ions and amine compounds	84	1.93e-01	0.082100	5.72e-01
Signaling by ERBB2	49	3.20e-01	0.082100	7.08e-01
Unwinding of DNA	12	6.23e-01	0.082000	8.71e-01
MAPK3 (ERK1) activation	10	6.53e-01	-0.082000	8.91e-01
Activation of gene expression by SREBF (SREBP)	42	3.59e-01	0.081800	7.41e-01
ROS and RNS production in phagocytes	35	4.03e-01	0.081700	7.64e-01
G-protein beta:gamma signalling	30	4.40e-01	-0.081500	7.73e-01
Glutamate Neurotransmitter Release Cycle	23	4.99e-01	0.081400	8.08e-01
Regulation of gene expression in beta cells	21	5.19e-01	0.081300	8.11e-01
Mitochondrial Fatty Acid Beta-Oxidation	35	4.05e-01	0.081300	7.67e-01
Metabolism of amine-derived hormones	17	5.62e-01	0.081100	8.36e-01
Reproduction	82	2.04e-01	-0.081100	5.91e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	3.69e-01	-0.081100	7.41e-01
Signaling by RAS mutants	41	3.69e-01	-0.081100	7.41e-01
Signaling by moderate kinase activity BRAF mutants	41	3.69e-01	-0.081100	7.41e-01
Signaling downstream of RAS mutants	41	3.69e-01	-0.081100	7.41e-01
NGF-stimulated transcription	39	3.82e-01	0.080900	7.45e-01
Activation of BH3-only proteins	30	4.43e-01	0.080900	7.73e-01
SUMOylation of ubiquitinylation proteins	37	3.95e-01	-0.080800	7.60e-01
ATF6 (ATF6-alpha) activates chaperones	11	6.44e-01	0.080400	8.85e-01
Inactivation of CSF3 (G-CSF) signaling	23	5.05e-01	0.080300	8.08e-01
Autophagy	125	1.22e-01	0.080100	4.56e-01
Interferon alpha/beta signaling	69	2.53e-01	-0.079500	6.51e-01
Nuclear Pore Complex (NPC) Disassembly	34	4.23e-01	-0.079400	7.73e-01
GPCR downstream signalling	603	8.93e-04	-0.079000	2.26e-02
Signaling by NOTCH	183	6.57e-02	0.078800	3.41e-01
Asparagine N-linked glycosylation	278	2.39e-02	0.078700	1.98e-01
Assembly of the ORC complex at the origin of replication	10	6.67e-01	-0.078500	8.99e-01
Transport of the SLBP independent Mature mRNA	33	4.37e-01	-0.078200	7.73e-01
DNA strand elongation	31	4.52e-01	0.078100	7.77e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	5.89e-01	0.078100	8.55e-01
Heparan sulfate/heparin (HS-GAG) metabolism	49	3.45e-01	0.077900	7.27e-01
RHO GTPase Effectors	232	4.14e-02	0.077700	2.80e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	4.02e-01	0.077500	7.64e-01
Diseases of DNA Double-Strand Break Repair	39	4.02e-01	0.077500	7.64e-01
ESR-mediated signaling	160	9.05e-02	0.077500	3.99e-01
Fatty acids	15	6.03e-01	-0.077500	8.64e-01
Diseases of metabolism	234	4.11e-02	0.077400	2.80e-01
Signaling by RAF1 mutants	37	4.17e-01	-0.077100	7.73e-01
Beta-catenin phosphorylation cascade	16	5.94e-01	-0.077000	8.58e-01
SUMOylation of chromatin organization proteins	54	3.28e-01	-0.076900	7.17e-01
Ethanol oxidation	12	6.46e-01	0.076500	8.85e-01
Defective B3GALTL causes PpS	36	4.27e-01	0.076500	7.73e-01
Metabolism of porphyrins	27	4.92e-01	-0.076400	8.07e-01
Resolution of D-Loop Structures	31	4.62e-01	0.076300	7.79e-01
Beta-oxidation of very long chain fatty acids	10	6.76e-01	-0.076300	9.01e-01
RHO GTPases Activate NADPH Oxidases	22	5.36e-01	-0.076200	8.24e-01
SUMOylation of RNA binding proteins	45	3.78e-01	-0.075900	7.44e-01
Transport of Mature mRNA Derived from an Intronless Transcript	40	4.06e-01	-0.075900	7.67e-01
Diseases associated with the TLR signaling cascade	29	4.79e-01	-0.075900	7.97e-01
Diseases of Immune System	29	4.79e-01	-0.075900	7.97e-01
Base Excision Repair	45	3.79e-01	0.075800	7.44e-01
Lagging Strand Synthesis	19	5.68e-01	0.075600	8.39e-01
Peroxisomal protein import	62	3.03e-01	0.075600	6.97e-01
Acyl chain remodelling of PG	18	5.80e-01	0.075300	8.49e-01
KEAP1-NFE2L2 pathway	103	1.87e-01	0.075300	5.64e-01
Signaling by EGFR	49	3.63e-01	0.075100	7.41e-01
CTNNB1 S33 mutants aren’t phosphorylated	14	6.27e-01	-0.075100	8.71e-01
CTNNB1 S37 mutants aren’t phosphorylated	14	6.27e-01	-0.075100	8.71e-01
CTNNB1 S45 mutants aren’t phosphorylated	14	6.27e-01	-0.075100	8.71e-01
CTNNB1 T41 mutants aren’t phosphorylated	14	6.27e-01	-0.075100	8.71e-01
Signaling by CTNNB1 phospho-site mutants	14	6.27e-01	-0.075100	8.71e-01
Signaling by GSK3beta mutants	14	6.27e-01	-0.075100	8.71e-01
CaM pathway	33	4.57e-01	-0.074900	7.79e-01
Calmodulin induced events	33	4.57e-01	-0.074900	7.79e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	95	2.08e-01	0.074800	5.97e-01
Regulation of PTEN stability and activity	66	2.94e-01	0.074600	6.88e-01
Class A/1 (Rhodopsin-like receptors)	311	2.38e-02	-0.074500	1.98e-01
Protein localization	147	1.20e-01	0.074300	4.53e-01
RHOH GTPase cycle	36	4.41e-01	-0.074300	7.73e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	29	4.89e-01	0.074200	8.03e-01
Tight junction interactions	28	4.97e-01	-0.074100	8.07e-01
Signaling by NTRK1 (TRKA)	114	1.72e-01	0.074100	5.45e-01
COPI-mediated anterograde transport	83	2.44e-01	0.073900	6.36e-01
RNA Polymerase II Transcription	1284	8.67e-06	0.073500	3.82e-04
Regulation of BACH1 activity	15	6.23e-01	0.073400	8.71e-01
Processing of Capped Intronless Pre-mRNA	28	5.02e-01	0.073200	8.08e-01
Glutathione conjugation	36	4.47e-01	0.073200	7.74e-01
Effects of PIP2 hydrolysis	26	5.19e-01	-0.073100	8.11e-01
Metabolism of non-coding RNA	50	3.71e-01	-0.073100	7.41e-01
snRNP Assembly	50	3.71e-01	-0.073100	7.41e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	11	6.76e-01	0.072900	9.01e-01
Pyrimidine catabolism	12	6.62e-01	-0.072800	8.96e-01
ER to Golgi Anterograde Transport	134	1.46e-01	0.072700	4.94e-01
Regulation of TP53 Activity	154	1.19e-01	0.072700	4.53e-01
Factors involved in megakaryocyte development and platelet production	128	1.56e-01	-0.072600	5.12e-01
Inactivation, recovery and regulation of the phototransduction cascade	31	4.88e-01	-0.072000	8.02e-01
Keratan sulfate biosynthesis	28	5.10e-01	-0.071900	8.10e-01
Generic Transcription Pathway	1163	3.54e-05	0.071600	1.26e-03
Aspartate and asparagine metabolism	11	6.81e-01	-0.071500	9.03e-01
Signaling by NOTCH1	70	3.01e-01	0.071400	6.95e-01
Hedgehog ‘off’ state	97	2.25e-01	0.071300	6.14e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	5.46e-01	0.071200	8.29e-01
Toll Like Receptor 3 (TLR3) Cascade	99	2.22e-01	0.071000	6.11e-01
Transcriptional Regulation by VENTX	41	4.31e-01	0.071000	7.73e-01
NOTCH3 Intracellular Domain Regulates Transcription	24	5.47e-01	0.071000	8.29e-01
Purine ribonucleoside monophosphate biosynthesis	11	6.85e-01	0.070700	9.04e-01
Recycling pathway of L1	23	5.57e-01	-0.070700	8.34e-01
Reduction of cytosolic Ca++ levels	11	6.85e-01	0.070700	9.04e-01
COPI-dependent Golgi-to-ER retrograde traffic	81	2.73e-01	0.070400	6.68e-01
Listeria monocytogenes entry into host cells	19	5.95e-01	0.070400	8.59e-01
Activation of G protein gated Potassium channels	29	5.12e-01	-0.070400	8.10e-01
G protein gated Potassium channels	29	5.12e-01	-0.070400	8.10e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	29	5.12e-01	-0.070400	8.10e-01
Eicosanoids	12	6.73e-01	0.070300	9.00e-01
Nicotinamide salvaging	17	6.16e-01	0.070200	8.71e-01
Gene expression (Transcription)	1420	8.90e-06	0.070000	3.82e-04
Defective Intrinsic Pathway for Apoptosis	25	5.46e-01	0.069700	8.29e-01
Diseases associated with O-glycosylation of proteins	66	3.28e-01	0.069600	7.17e-01
G alpha (q) signalling events	206	8.50e-02	-0.069600	3.89e-01
Cargo recognition for clathrin-mediated endocytosis	98	2.34e-01	0.069500	6.23e-01
Thrombin signalling through proteinase activated receptors (PARs)	32	4.96e-01	-0.069500	8.07e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37	4.66e-01	-0.069300	7.83e-01
CTLA4 inhibitory signaling	21	5.83e-01	-0.069200	8.50e-01
Signaling by GPCR	670	2.30e-03	-0.068900	4.61e-02
Adenylate cyclase activating pathway	10	7.07e-01	0.068700	9.08e-01
Sphingolipid de novo biosynthesis	41	4.47e-01	-0.068600	7.74e-01
Signaling by FGFR4 in disease	11	6.94e-01	0.068500	9.05e-01
The phototransduction cascade	32	5.03e-01	-0.068400	8.08e-01
Transcriptional regulation by small RNAs	46	4.23e-01	0.068200	7.73e-01
Removal of the Flap Intermediate	13	6.71e-01	0.068000	9.00e-01
Transcriptional Regulation by E2F6	32	5.07e-01	-0.067800	8.08e-01
Negative regulators of DDX58/IFIH1 signaling	34	4.95e-01	0.067600	8.07e-01
HDACs deacetylate histones	29	5.30e-01	0.067400	8.19e-01
Interleukin-27 signaling	11	6.99e-01	-0.067300	9.06e-01
Cell Cycle	601	4.80e-03	0.067200	7.39e-02
RAB geranylgeranylation	57	3.80e-01	0.067200	7.45e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	29	5.31e-01	0.067200	8.19e-01
Defects in cobalamin (B12) metabolism	12	6.87e-01	0.067100	9.04e-01
Host Interactions of HIV factors	122	2.01e-01	0.066900	5.88e-01
Organic cation/anion/zwitterion transport	15	6.55e-01	0.066600	8.91e-01
Activated NTRK2 signals through FRS2 and FRS3	11	7.02e-01	-0.066600	9.07e-01
Potential therapeutics for SARS	92	2.70e-01	0.066500	6.68e-01
Adrenaline,noradrenaline inhibits insulin secretion	28	5.43e-01	0.066400	8.28e-01
ADORA2B mediated anti-inflammatory cytokines production	42	4.60e-01	-0.065800	7.79e-01
NOTCH1 Intracellular Domain Regulates Transcription	44	4.51e-01	0.065700	7.76e-01
Regulation of PLK1 Activity at G2/M Transition	83	3.01e-01	0.065600	6.95e-01
Signaling by Hedgehog	133	1.92e-01	0.065500	5.70e-01
Sensory processing of sound by inner hair cells of the cochlea	62	3.73e-01	0.065400	7.41e-01
Mucopolysaccharidoses	10	7.21e-01	0.065200	9.12e-01
Formation of the beta-catenin:TCF transactivating complex	32	5.24e-01	0.065200	8.13e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	30	5.38e-01	0.064900	8.25e-01
PCP/CE pathway	90	2.87e-01	0.064900	6.86e-01
Export of Viral Ribonucleoproteins from Nucleus	31	5.32e-01	-0.064900	8.19e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	5.39e-01	-0.064900	8.25e-01
PKMTs methylate histone lysines	37	4.95e-01	-0.064800	8.07e-01
Inositol phosphate metabolism	45	4.53e-01	0.064600	7.78e-01
Regulation of beta-cell development	41	4.74e-01	0.064600	7.93e-01
Degradation of beta-catenin by the destruction complex	81	3.16e-01	0.064500	7.02e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27	5.63e-01	-0.064400	8.36e-01
Hemostasis	555	9.63e-03	-0.064100	1.21e-01
Complex I biogenesis	49	4.37e-01	0.064100	7.73e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	7.01e-01	-0.064000	9.07e-01
ATF4 activates genes in response to endoplasmic reticulum stress	28	5.58e-01	0.063900	8.35e-01
Disorders of Developmental Biology	11	7.14e-01	0.063800	9.09e-01
Disorders of Nervous System Development	11	7.14e-01	0.063800	9.09e-01
Loss of function of MECP2 in Rett syndrome	11	7.14e-01	0.063800	9.09e-01
Pervasive developmental disorders	11	7.14e-01	0.063800	9.09e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	41	4.80e-01	-0.063700	7.98e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	35	5.15e-01	0.063600	8.11e-01
Metal ion SLC transporters	25	5.82e-01	0.063500	8.50e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	106	2.59e-01	0.063500	6.52e-01
Toll Like Receptor 2 (TLR2) Cascade	106	2.59e-01	0.063500	6.52e-01
Toll Like Receptor TLR1:TLR2 Cascade	106	2.59e-01	0.063500	6.52e-01
Toll Like Receptor TLR6:TLR2 Cascade	106	2.59e-01	0.063500	6.52e-01
Transport of the SLBP Dependant Mature mRNA	34	5.23e-01	-0.063300	8.13e-01
Cellular response to chemical stress	187	1.36e-01	0.063200	4.81e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	7.30e-01	0.062900	9.14e-01
TCF dependent signaling in response to WNT	168	1.60e-01	0.062800	5.21e-01
Signaling by FGFR3 in disease	21	6.18e-01	0.062800	8.71e-01
Thyroxine biosynthesis	10	7.31e-01	-0.062700	9.14e-01
MAPK targets/ Nuclear events mediated by MAP kinases	29	5.61e-01	0.062300	8.36e-01
Stimuli-sensing channels	96	2.91e-01	0.062300	6.88e-01
Endogenous sterols	26	5.84e-01	0.062100	8.50e-01
PKA-mediated phosphorylation of CREB	19	6.39e-01	-0.062100	8.81e-01
G-protein mediated events	52	4.40e-01	-0.061900	7.73e-01
DARPP-32 events	24	6.00e-01	0.061800	8.64e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	6.79e-01	0.061800	9.03e-01
Post-translational modification: synthesis of GPI-anchored proteins	89	3.14e-01	0.061800	7.01e-01
RUNX3 regulates NOTCH signaling	13	7.00e-01	0.061700	9.06e-01
Signaling by Nuclear Receptors	237	1.03e-01	0.061400	4.17e-01
O-linked glycosylation of mucins	62	4.04e-01	-0.061200	7.66e-01
Diseases associated with visual transduction	11	7.25e-01	-0.061200	9.12e-01
Diseases of the neuronal system	11	7.25e-01	-0.061200	9.12e-01
Retinoid cycle disease events	11	7.25e-01	-0.061200	9.12e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	43	4.88e-01	0.061200	8.02e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	7.03e-01	0.061200	9.07e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	21	6.28e-01	0.061100	8.71e-01
Signaling by Insulin receptor	77	3.54e-01	0.061000	7.39e-01
Downstream signaling of activated FGFR2	29	5.70e-01	0.060900	8.40e-01
Post-translational protein phosphorylation	100	2.94e-01	-0.060700	6.88e-01
Constitutive Signaling by Aberrant PI3K in Cancer	77	3.58e-01	-0.060600	7.41e-01
MAP kinase activation	58	4.25e-01	0.060600	7.73e-01
Nuclear events stimulated by ALK signaling in cancer	18	6.57e-01	-0.060500	8.92e-01
Presynaptic phase of homologous DNA pairing and strand exchange	38	5.19e-01	0.060500	8.11e-01
RAB GEFs exchange GTP for GDP on RABs	82	3.45e-01	-0.060400	7.27e-01
Signaling by the B Cell Receptor (BCR)	105	2.86e-01	0.060300	6.86e-01
Peptide ligand-binding receptors	190	1.52e-01	-0.060200	5.03e-01
Transcriptional activation of mitochondrial biogenesis	51	4.58e-01	0.060100	7.79e-01
Digestion and absorption	23	6.21e-01	-0.059600	8.71e-01
Regulation of KIT signaling	16	6.81e-01	-0.059300	9.03e-01
Golgi-to-ER retrograde transport	115	2.73e-01	0.059200	6.68e-01
Cell death signalling via NRAGE, NRIF and NADE	69	3.97e-01	0.058900	7.60e-01
Toll Like Receptor 9 (TLR9) Cascade	100	3.09e-01	0.058900	6.98e-01
PECAM1 interactions	12	7.24e-01	-0.058800	9.12e-01
Glucagon signaling in metabolic regulation	33	5.61e-01	-0.058500	8.36e-01
Oncogenic MAPK signaling	76	3.78e-01	-0.058400	7.44e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	7.05e-01	0.058400	9.08e-01
Signal amplification	33	5.62e-01	-0.058300	8.36e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	89	3.42e-01	0.058300	7.24e-01
Amplification of signal from the kinetochores	89	3.42e-01	0.058300	7.24e-01
Metabolism of steroids	148	2.22e-01	-0.058100	6.11e-01
Cellular hexose transport	21	6.45e-01	0.058000	8.85e-01
Diseases of glycosylation	137	2.43e-01	0.057700	6.36e-01
Chondroitin sulfate biosynthesis	18	6.73e-01	-0.057500	9.00e-01
Neutrophil degranulation	458	3.50e-02	-0.057400	2.52e-01
FCGR3A-mediated IL10 synthesis	37	5.47e-01	-0.057300	8.29e-01
M Phase	335	7.13e-02	0.057300	3.51e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21	6.50e-01	0.057200	8.88e-01
Resolution of Sister Chromatid Cohesion	98	3.30e-01	0.056900	7.18e-01
GAB1 signalosome	17	6.85e-01	0.056900	9.04e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	7.44e-01	0.056900	9.19e-01
Mismatch Repair	15	7.03e-01	0.056800	9.08e-01
Signaling by ERBB4	57	4.58e-01	0.056800	7.79e-01
Mitochondrial biogenesis	69	4.16e-01	0.056600	7.73e-01
Metabolism	1963	3.01e-05	0.056600	1.16e-03
The role of Nef in HIV-1 replication and disease pathogenesis	27	6.11e-01	0.056500	8.67e-01
Activation of the pre-replicative complex	31	5.86e-01	-0.056400	8.53e-01
Signaling by PDGFRA extracellular domain mutants	12	7.35e-01	-0.056300	9.15e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	7.35e-01	-0.056300	9.15e-01
Norepinephrine Neurotransmitter Release Cycle	16	6.97e-01	0.056300	9.05e-01
p75 NTR receptor-mediated signalling	89	3.60e-01	0.056200	7.41e-01
Trafficking of GluR2-containing AMPA receptors	15	7.07e-01	-0.056100	9.08e-01
Bicarbonate transporters	10	7.59e-01	-0.056100	9.24e-01
Glucose metabolism	87	3.66e-01	0.056000	7.41e-01
Amyloid fiber formation	53	4.82e-01	0.055900	7.98e-01
Signaling by ALK	26	6.22e-01	0.055900	8.71e-01
Signaling by Erythropoietin	25	6.29e-01	-0.055900	8.72e-01
Synthesis of PIPs at the plasma membrane	48	5.04e-01	-0.055700	8.08e-01
Creation of C4 and C2 activators	14	7.18e-01	0.055700	9.11e-01
Regulation of actin dynamics for phagocytic cup formation	59	4.61e-01	0.055400	7.79e-01
Mitochondrial calcium ion transport	22	6.54e-01	-0.055200	8.91e-01
FRS-mediated FGFR2 signaling	24	6.40e-01	0.055200	8.81e-01
Defective GALNT3 causes HFTC	18	6.86e-01	0.055000	9.04e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	20	6.71e-01	-0.054900	9.00e-01
Acetylcholine binding and downstream events	14	7.22e-01	0.054900	9.12e-01
Postsynaptic nicotinic acetylcholine receptors	14	7.22e-01	0.054900	9.12e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	7.42e-01	0.054900	9.18e-01
Defective EXT2 causes exostoses 2	12	7.42e-01	0.054900	9.18e-01
Nuclear Envelope Breakdown	50	5.03e-01	-0.054700	8.08e-01
Cell Cycle, Mitotic	476	4.09e-02	0.054600	2.80e-01
Antigen processing-Cross presentation	100	3.46e-01	0.054500	7.27e-01
Signaling by NTRKs	133	2.77e-01	0.054500	6.77e-01
ALK mutants bind TKIs	12	7.45e-01	-0.054300	9.19e-01
PI-3K cascade:FGFR2	22	6.59e-01	0.054300	8.94e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	16	7.08e-01	0.054100	9.08e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	38	5.64e-01	-0.054100	8.36e-01
HDR through MMEJ (alt-NHEJ)	11	7.56e-01	-0.054000	9.23e-01
Extension of Telomeres	48	5.20e-01	0.053700	8.11e-01
Signaling by MET	66	4.51e-01	0.053700	7.76e-01
Processing and activation of SUMO	10	7.70e-01	0.053500	9.29e-01
Cargo concentration in the ER	32	6.01e-01	0.053400	8.64e-01
Clathrin-mediated endocytosis	135	2.85e-01	0.053300	6.86e-01
Platelet activation, signaling and aggregation	245	1.51e-01	-0.053300	5.01e-01
Vasopressin regulates renal water homeostasis via Aquaporins	42	5.52e-01	-0.053000	8.33e-01
Sensory processing of sound	69	4.47e-01	0.053000	7.74e-01
EPH-Ephrin signaling	90	3.86e-01	0.052900	7.50e-01
Unblocking of NMDA receptors, glutamate binding and activation	19	6.91e-01	-0.052600	9.04e-01
Infectious disease	830	9.86e-03	0.052600	1.22e-01
Post-chaperonin tubulin folding pathway	23	6.63e-01	-0.052400	8.96e-01
Immune System	1870	1.57e-04	-0.052400	4.74e-03
Response of Mtb to phagocytosis	22	6.72e-01	0.052200	9.00e-01
Formation of apoptosome	10	7.75e-01	-0.052200	9.30e-01
Regulation of the apoptosome activity	10	7.75e-01	-0.052200	9.30e-01
Transport of Mature Transcript to Cytoplasm	76	4.32e-01	0.052200	7.73e-01
SLC-mediated transmembrane transport	238	1.68e-01	0.051900	5.36e-01
Extra-nuclear estrogen signaling	73	4.43e-01	0.051900	7.73e-01
Adaptive Immune System	709	1.83e-02	-0.051900	1.74e-01
FCERI mediated MAPK activation	29	6.30e-01	-0.051700	8.73e-01
Apoptotic factor-mediated response	17	7.13e-01	-0.051600	9.09e-01
IKK complex recruitment mediated by RIP1	22	6.75e-01	-0.051600	9.01e-01
WNT5A-dependent internalization of FZD4	15	7.31e-01	-0.051200	9.14e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	7.59e-01	0.051000	9.24e-01
Regulated Necrosis	53	5.21e-01	-0.050900	8.12e-01
Downstream TCR signaling	92	3.99e-01	0.050900	7.61e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	67	4.72e-01	0.050800	7.91e-01
Cyclin A/B1/B2 associated events during G2/M transition	24	6.69e-01	0.050500	9.00e-01
EPHB-mediated forward signaling	34	6.12e-01	-0.050300	8.67e-01
Ras activation upon Ca2+ influx through NMDA receptor	19	7.05e-01	0.050100	9.08e-01
Downstream signaling of activated FGFR4	26	6.59e-01	0.050000	8.94e-01
Elevation of cytosolic Ca2+ levels	16	7.29e-01	-0.050000	9.14e-01
Transcriptional regulation of pluripotent stem cells	30	6.36e-01	0.050000	8.77e-01
GABA receptor activation	57	5.16e-01	-0.049800	8.11e-01
Cell-Cell communication	112	3.66e-01	-0.049500	7.41e-01
Signaling by TGFB family members	118	3.55e-01	0.049300	7.40e-01
Phase I - Functionalization of compounds	100	3.98e-01	0.048900	7.60e-01
Metabolism of vitamins and cofactors	181	2.62e-01	0.048300	6.56e-01
RHOBTB GTPase Cycle	34	6.27e-01	-0.048100	8.71e-01
Metabolism of carbohydrates	275	1.71e-01	0.048000	5.44e-01
Visual phototransduction	93	4.24e-01	0.047900	7.73e-01
Nuclear Envelope (NE) Reassembly	73	4.83e-01	0.047500	7.98e-01
CS/DS degradation	12	7.76e-01	0.047500	9.30e-01
RHO GTPase cycle	420	9.63e-02	-0.047200	4.09e-01
Signal transduction by L1	20	7.16e-01	0.047100	9.10e-01
SUMOylation of transcription cofactors	43	5.98e-01	0.046400	8.62e-01
Mitotic G2-G2/M phases	177	2.88e-01	0.046300	6.86e-01
STING mediated induction of host immune responses	13	7.73e-01	-0.046300	9.29e-01
Regulation of lipid metabolism by PPARalpha	116	3.89e-01	0.046300	7.55e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	22	7.08e-01	0.046100	9.08e-01
Neurodegenerative Diseases	22	7.08e-01	0.046100	9.08e-01
Platelet homeostasis	85	4.62e-01	-0.046100	7.79e-01
Condensation of Prophase Chromosomes	12	7.82e-01	-0.046100	9.32e-01
G2/M Transition	175	2.93e-01	0.046000	6.88e-01
Nuclear import of Rev protein	32	6.53e-01	-0.045900	8.91e-01
NRAGE signals death through JNK	53	5.64e-01	-0.045900	8.36e-01
Miscellaneous transport and binding events	21	7.17e-01	-0.045700	9.10e-01
Activation of Matrix Metalloproteinases	31	6.60e-01	0.045600	8.94e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	117	3.96e-01	-0.045400	7.60e-01
GABA synthesis, release, reuptake and degradation	19	7.33e-01	0.045300	9.15e-01
Signaling by Receptor Tyrosine Kinases	493	8.49e-02	0.045200	3.89e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	12	7.87e-01	0.045000	9.32e-01
Integration of energy metabolism	106	4.25e-01	0.044800	7.73e-01
Gap junction assembly	18	7.42e-01	0.044800	9.18e-01
Negative regulation of MAPK pathway	41	6.24e-01	0.044300	8.71e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	6.80e-01	0.044300	9.03e-01
Trafficking of AMPA receptors	29	6.80e-01	0.044300	9.03e-01
RHO GTPases activate IQGAPs	11	8.01e-01	-0.043900	9.32e-01
G alpha (12/13) signalling events	74	5.17e-01	-0.043600	8.11e-01
Innate Immune System	999	1.94e-02	-0.043600	1.79e-01
Activation of the phototransduction cascade	11	8.03e-01	0.043400	9.32e-01
PIP3 activates AKT signaling	275	2.15e-01	0.043400	6.04e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	7.08e-01	0.043300	9.08e-01
PPARA activates gene expression	114	4.31e-01	0.042700	7.73e-01
RAF activation	33	6.72e-01	0.042600	9.00e-01
Arachidonic acid metabolism	56	5.83e-01	0.042500	8.50e-01
Protein-protein interactions at synapses	78	5.17e-01	0.042400	8.11e-01
Metabolism of proteins	1767	2.96e-03	0.042300	5.51e-02
Disease	1567	4.99e-03	0.042300	7.42e-02
Synthesis of PIPs at the Golgi membrane	17	7.64e-01	-0.042100	9.27e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	7.94e-01	0.041800	9.32e-01
TP53 Regulates Transcription of Cell Death Genes	42	6.40e-01	-0.041700	8.81e-01
MASTL Facilitates Mitotic Progression	10	8.20e-01	0.041500	9.38e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	7.96e-01	-0.041300	9.32e-01
Ovarian tumor domain proteases	36	6.69e-01	-0.041100	9.00e-01
CD28 co-stimulation	32	6.88e-01	-0.041000	9.04e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	6.79e-01	0.041000	9.03e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	6.20e-01	-0.041000	8.71e-01
FRS-mediated FGFR4 signaling	21	7.45e-01	0.040900	9.19e-01
Protein folding	96	4.88e-01	-0.040900	8.02e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	52	6.10e-01	0.040900	8.67e-01
Meiotic synapsis	32	6.90e-01	0.040700	9.04e-01
Insulin receptor signalling cascade	53	6.08e-01	0.040700	8.66e-01
Peroxisomal lipid metabolism	28	7.09e-01	0.040700	9.08e-01
Ca2+ pathway	62	5.80e-01	-0.040600	8.49e-01
Nuclear signaling by ERBB4	32	6.92e-01	-0.040400	9.04e-01
Paracetamol ADME	27	7.16e-01	-0.040400	9.10e-01
Phospholipid metabolism	192	3.35e-01	0.040300	7.21e-01
Transport of small molecules	689	7.07e-02	0.040300	3.49e-01
Carnitine metabolism	11	8.17e-01	0.040300	9.37e-01
Postmitotic nuclear pore complex (NPC) reformation	26	7.22e-01	0.040300	9.12e-01
Blood group systems biosynthesis	22	7.44e-01	-0.040200	9.19e-01
Meiosis	56	6.03e-01	-0.040200	8.64e-01
TNFR1-induced proapoptotic signaling	13	8.03e-01	-0.040000	9.32e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	32	6.95e-01	0.040000	9.05e-01
Rev-mediated nuclear export of HIV RNA	33	6.92e-01	-0.039800	9.04e-01
Defective GALNT12 causes CRCS1	18	7.70e-01	0.039700	9.29e-01
FLT3 Signaling	38	6.73e-01	-0.039500	9.00e-01
Negative regulation of the PI3K/AKT network	111	4.72e-01	-0.039500	7.91e-01
Phase II - Conjugation of compounds	106	4.82e-01	-0.039500	7.98e-01
Anti-inflammatory response favouring Leishmania parasite infection	75	5.55e-01	-0.039400	8.33e-01
Leishmania parasite growth and survival	75	5.55e-01	-0.039400	8.33e-01
Biotin transport and metabolism	10	8.30e-01	0.039300	9.41e-01
Heme biosynthesis	13	8.06e-01	-0.039300	9.32e-01
Cilium Assembly	174	3.73e-01	-0.039100	7.41e-01
Nucleotide catabolism	35	6.90e-01	0.039000	9.04e-01
PKA activation	18	7.76e-01	-0.038700	9.30e-01
Costimulation by the CD28 family	65	5.91e-01	-0.038500	8.57e-01
APC truncation mutants have impaired AXIN binding	13	8.11e-01	-0.038400	9.32e-01
AXIN missense mutants destabilize the destruction complex	13	8.11e-01	-0.038400	9.32e-01
Signaling by AMER1 mutants	13	8.11e-01	-0.038400	9.32e-01
Signaling by APC mutants	13	8.11e-01	-0.038400	9.32e-01
Signaling by AXIN mutants	13	8.11e-01	-0.038400	9.32e-01
Truncations of AMER1 destabilize the destruction complex	13	8.11e-01	-0.038400	9.32e-01
Purine catabolism	17	7.84e-01	0.038400	9.32e-01
PI-3K cascade:FGFR4	19	7.72e-01	0.038300	9.29e-01
Interleukin-17 signaling	66	5.90e-01	0.038300	8.56e-01
Response to metal ions	14	8.04e-01	-0.038300	9.32e-01
Transcriptional regulation of white adipocyte differentiation	81	5.53e-01	0.038100	8.33e-01
ER-Phagosome pathway	87	5.40e-01	0.038000	8.25e-01
Fatty acid metabolism	167	3.97e-01	0.038000	7.60e-01
EML4 and NUDC in mitotic spindle formation	93	5.27e-01	0.038000	8.17e-01
GPER1 signaling	44	6.65e-01	0.037700	8.97e-01
Regulation of insulin secretion	77	5.69e-01	0.037500	8.40e-01
HS-GAG biosynthesis	28	7.32e-01	0.037400	9.14e-01
Opioid Signalling	88	5.45e-01	-0.037300	8.29e-01
Regulation of RUNX1 Expression and Activity	25	7.47e-01	-0.037300	9.19e-01
tRNA processing in the nucleus	55	6.34e-01	0.037100	8.76e-01
Nephrin family interactions	21	7.68e-01	-0.037100	9.29e-01
Hyaluronan uptake and degradation	12	8.24e-01	0.037100	9.38e-01
Golgi Associated Vesicle Biogenesis	51	6.48e-01	-0.036900	8.86e-01
RHOF GTPase cycle	40	6.88e-01	-0.036700	9.04e-01
Signaling by VEGF	101	5.25e-01	0.036600	8.15e-01
MET activates PTK2 signaling	18	7.90e-01	0.036300	9.32e-01
Sialic acid metabolism	33	7.20e-01	-0.036100	9.12e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	8.29e-01	-0.036100	9.41e-01
Interferon Signaling	191	3.91e-01	-0.036000	7.58e-01
Serotonin Neurotransmitter Release Cycle	16	8.05e-01	0.035700	9.32e-01
Amine ligand-binding receptors	41	6.95e-01	0.035400	9.05e-01
Prefoldin mediated transfer of substrate to CCT/TriC	27	7.50e-01	0.035400	9.20e-01
Circadian Clock	69	6.12e-01	0.035300	8.67e-01
Hyaluronan metabolism	17	8.02e-01	0.035200	9.32e-01
Extracellular matrix organization	287	3.05e-01	0.035200	6.97e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	8.50e-01	0.034600	9.53e-01
Pre-NOTCH Transcription and Translation	45	6.89e-01	0.034500	9.04e-01
Centrosome maturation	76	6.05e-01	-0.034300	8.64e-01
Recruitment of mitotic centrosome proteins and complexes	76	6.05e-01	-0.034300	8.64e-01
EPHA-mediated growth cone collapse	15	8.18e-01	0.034300	9.38e-01
tRNA Aminoacylation	24	7.72e-01	-0.034200	9.29e-01
Platelet sensitization by LDL	17	8.07e-01	-0.034100	9.32e-01
Intraflagellar transport	36	7.26e-01	-0.033700	9.13e-01
Chromatin modifying enzymes	186	4.29e-01	0.033600	7.73e-01
Chromatin organization	186	4.29e-01	0.033600	7.73e-01
Endosomal/Vacuolar pathway	12	8.40e-01	0.033600	9.48e-01
RAF-independent MAPK1/3 activation	22	7.87e-01	0.033300	9.32e-01
Synthesis, secretion, and deacylation of Ghrelin	19	8.01e-01	0.033300	9.32e-01
Oxidative Stress Induced Senescence	66	6.40e-01	-0.033200	8.81e-01
Repression of WNT target genes	13	8.36e-01	0.033200	9.45e-01
Processing of Intronless Pre-mRNAs	19	8.03e-01	0.033000	9.32e-01
Signaling by FGFR in disease	61	6.57e-01	0.032900	8.92e-01
Mitochondrial tRNA aminoacylation	18	8.10e-01	0.032700	9.32e-01
Death Receptor Signalling	134	5.14e-01	0.032700	8.11e-01
Diseases of DNA repair	49	6.92e-01	0.032700	9.04e-01
G alpha (z) signalling events	48	6.97e-01	-0.032500	9.05e-01
RHOC GTPase cycle	69	6.41e-01	-0.032400	8.81e-01
Assembly and cell surface presentation of NMDA receptors	23	7.88e-01	-0.032400	9.32e-01
Membrane Trafficking	585	1.81e-01	0.032300	5.56e-01
COPI-independent Golgi-to-ER retrograde traffic	34	7.46e-01	0.032100	9.19e-01
Signaling by Hippo	19	8.09e-01	-0.032100	9.32e-01
HDR through Single Strand Annealing (SSA)	36	7.42e-01	0.031700	9.18e-01
Interferon gamma signaling	89	6.06e-01	-0.031700	8.64e-01
Neuronal System	371	2.95e-01	0.031600	6.88e-01
Glycogen breakdown (glycogenolysis)	11	8.57e-01	0.031400	9.53e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	8.13e-01	0.031300	9.35e-01
Deposition of new CENPA-containing nucleosomes at the centromere	26	7.82e-01	0.031300	9.32e-01
Nucleosome assembly	26	7.82e-01	0.031300	9.32e-01
Acetylcholine Neurotransmitter Release Cycle	16	8.28e-01	0.031300	9.41e-01
Glycosphingolipid metabolism	40	7.33e-01	0.031200	9.15e-01
G alpha (s) signalling events	153	5.08e-01	-0.031000	8.09e-01
Signaling by PDGF	52	6.99e-01	-0.031000	9.06e-01
SLC transporter disorders	92	6.12e-01	0.030600	8.67e-01
C-type lectin receptors (CLRs)	137	5.37e-01	0.030500	8.25e-01
Collagen degradation	39	7.42e-01	-0.030500	9.18e-01
Glycolysis	68	6.65e-01	0.030300	8.97e-01
PERK regulates gene expression	32	7.67e-01	0.030200	9.29e-01
Interleukin-6 family signaling	24	7.98e-01	-0.030100	9.32e-01
Cholesterol biosynthesis	24	7.99e-01	-0.030000	9.32e-01
TNFR1-induced NFkappaB signaling pathway	22	8.08e-01	0.030000	9.32e-01
Serotonin receptors	11	8.63e-01	-0.030000	9.53e-01
Notch-HLH transcription pathway	24	7.99e-01	-0.030000	9.32e-01
Negative regulation of FLT3	15	8.42e-01	0.029700	9.49e-01
Diseases associated with glycosaminoglycan metabolism	38	7.52e-01	-0.029600	9.21e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	8.60e-01	0.029500	9.53e-01
alpha-linolenic acid (ALA) metabolism	12	8.60e-01	0.029500	9.53e-01
Synthesis of very long-chain fatty acyl-CoAs	23	8.07e-01	-0.029400	9.32e-01
Transport to the Golgi and subsequent modification	165	5.16e-01	0.029300	8.11e-01
tRNA modification in the nucleus and cytosol	38	7.55e-01	-0.029300	9.22e-01
Chaperonin-mediated protein folding	90	6.32e-01	-0.029200	8.75e-01
Transcriptional regulation by RUNX1	183	4.96e-01	0.029100	8.07e-01
Pyruvate metabolism	29	7.86e-01	-0.029100	9.32e-01
Nonhomologous End-Joining (NHEJ)	32	7.76e-01	0.029000	9.30e-01
RHOB GTPase cycle	66	6.84e-01	-0.029000	9.04e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	8.52e-01	0.028700	9.53e-01
SARS-CoV Infections	387	3.32e-01	0.028700	7.20e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	27	7.97e-01	-0.028700	9.32e-01
Retrograde neurotrophin signalling	14	8.53e-01	-0.028600	9.53e-01
Intrinsic Pathway for Apoptosis	52	7.25e-01	0.028200	9.12e-01
Intracellular signaling by second messengers	313	3.90e-01	0.028200	7.57e-01
Nicotinate metabolism	29	7.94e-01	0.028000	9.32e-01
Cargo trafficking to the periciliary membrane	49	7.35e-01	-0.027900	9.15e-01
The NLRP3 inflammasome	16	8.47e-01	-0.027900	9.52e-01
The canonical retinoid cycle in rods (twilight vision)	23	8.17e-01	0.027900	9.37e-01
Developmental Biology	1027	1.32e-01	0.027700	4.74e-01
MyD88-independent TLR4 cascade	103	6.27e-01	0.027700	8.71e-01
TRIF(TICAM1)-mediated TLR4 signaling	103	6.27e-01	0.027700	8.71e-01
Signaling by WNT	263	4.39e-01	0.027700	7.73e-01
trans-Golgi Network Vesicle Budding	67	6.97e-01	-0.027500	9.05e-01
Viral Messenger RNA Synthesis	42	7.58e-01	0.027400	9.24e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	8.81e-01	-0.027400	9.56e-01
Class B/2 (Secretin family receptors)	94	6.46e-01	0.027400	8.85e-01
Rap1 signalling	16	8.51e-01	0.027100	9.53e-01
SUMOylation of SUMOylation proteins	33	7.88e-01	-0.027100	9.32e-01
Neurotransmitter receptors and postsynaptic signal transmission	175	5.36e-01	-0.027100	8.24e-01
Semaphorin interactions	61	7.15e-01	0.027100	9.09e-01
NOD1/2 Signaling Pathway	29	8.02e-01	-0.026900	9.32e-01
SUMOylation of DNA methylation proteins	16	8.54e-01	-0.026600	9.53e-01
Interleukin-1 family signaling	145	5.80e-01	0.026600	8.49e-01
Platelet degranulation	115	6.23e-01	-0.026500	8.71e-01
PI Metabolism	79	6.88e-01	-0.026100	9.04e-01
Ephrin signaling	17	8.53e-01	0.026000	9.53e-01
Aquaporin-mediated transport	51	7.48e-01	-0.026000	9.20e-01
Regulation of IFNG signaling	14	8.69e-01	0.025500	9.53e-01
Physiological factors	14	8.70e-01	0.025300	9.53e-01
Anchoring of the basal body to the plasma membrane	92	6.76e-01	-0.025200	9.01e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	8.49e-01	-0.025200	9.53e-01
Ion channel transport	168	5.75e-01	0.025000	8.45e-01
RHO GTPases Activate WASPs and WAVEs	34	8.03e-01	0.024700	9.32e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	52	7.59e-01	0.024600	9.24e-01
Degradation of the extracellular matrix	108	6.59e-01	0.024600	8.94e-01
Interactions of Rev with host cellular proteins	35	8.01e-01	-0.024600	9.32e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	8.74e-01	0.024500	9.55e-01
Integrin signaling	27	8.26e-01	-0.024500	9.39e-01
Response to elevated platelet cytosolic Ca2+	120	6.47e-01	-0.024200	8.85e-01
DSCAM interactions	11	8.90e-01	-0.024100	9.62e-01
RUNX2 regulates bone development	29	8.23e-01	0.024000	9.38e-01
FCGR3A-mediated phagocytosis	57	7.55e-01	0.023900	9.22e-01
Leishmania phagocytosis	57	7.55e-01	0.023900	9.22e-01
Parasite infection	57	7.55e-01	0.023900	9.22e-01
SUMOylation of DNA replication proteins	44	7.84e-01	0.023900	9.32e-01
VEGFA-VEGFR2 Pathway	93	6.90e-01	0.023900	9.04e-01
Digestion	18	8.61e-01	-0.023800	9.53e-01
HDMs demethylate histones	18	8.64e-01	-0.023400	9.53e-01
E3 ubiquitin ligases ubiquitinate target proteins	43	7.93e-01	-0.023100	9.32e-01
PD-1 signaling	21	8.55e-01	0.023100	9.53e-01
Processing of SMDT1	15	8.78e-01	-0.022800	9.56e-01
Downstream signal transduction	29	8.31e-01	0.022800	9.42e-01
Deadenylation-dependent mRNA decay	56	7.68e-01	0.022800	9.29e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	8.75e-01	-0.022700	9.55e-01
Vitamin D (calciferol) metabolism	12	8.92e-01	-0.022700	9.62e-01
Leishmania infection	156	6.28e-01	-0.022500	8.71e-01
IGF1R signaling cascade	51	7.83e-01	0.022300	9.32e-01
SUMOylation	164	6.26e-01	-0.022000	8.71e-01
Aflatoxin activation and detoxification	19	8.69e-01	0.021800	9.53e-01
ZBP1(DAI) mediated induction of type I IFNs	20	8.66e-01	-0.021700	9.53e-01
Neurexins and neuroligins	52	7.87e-01	-0.021700	9.32e-01
Activation of ATR in response to replication stress	37	8.21e-01	0.021500	9.38e-01
Vesicle-mediated transport	623	3.60e-01	0.021400	7.41e-01
Fcgamma receptor (FCGR) dependent phagocytosis	82	7.38e-01	0.021400	9.17e-01
Chondroitin sulfate/dermatan sulfate metabolism	45	8.05e-01	0.021200	9.32e-01
Gastrulation	21	8.66e-01	-0.021200	9.53e-01
Translocation of ZAP-70 to Immunological synapse	17	8.80e-01	-0.021200	9.56e-01
Pre-NOTCH Expression and Processing	61	7.78e-01	0.020900	9.30e-01
PI3K/AKT Signaling in Cancer	103	7.14e-01	-0.020900	9.09e-01
Collagen biosynthesis and modifying enzymes	65	7.71e-01	0.020900	9.29e-01
Triglyceride biosynthesis	13	8.97e-01	0.020800	9.64e-01
Gastrin-CREB signalling pathway via PKC and MAPK	17	8.82e-01	0.020700	9.57e-01
Collagen formation	88	7.37e-01	0.020700	9.17e-01
Collagen chain trimerization	42	8.20e-01	-0.020300	9.38e-01
Gap junction trafficking	27	8.55e-01	-0.020300	9.53e-01
Telomere Extension By Telomerase	22	8.70e-01	0.020200	9.53e-01
NR1H2 and NR1H3-mediated signaling	53	7.99e-01	0.020200	9.32e-01
IRS-related events triggered by IGF1R	50	8.05e-01	0.020200	9.32e-01
Signaling by Retinoic Acid	41	8.23e-01	0.020200	9.38e-01
Sensory processing of sound by outer hair cells of the cochlea	49	8.08e-01	0.020100	9.32e-01
Interleukin-12 family signaling	53	8.00e-01	-0.020100	9.32e-01
Rab regulation of trafficking	113	7.13e-01	0.020100	9.09e-01
SLBP independent Processing of Histone Pre-mRNAs	10	9.13e-01	0.020000	9.69e-01
Long-term potentiation	22	8.71e-01	-0.020000	9.53e-01
Post-translational protein modification	1289	2.31e-01	0.019700	6.18e-01
Growth hormone receptor signaling	24	8.68e-01	0.019700	9.53e-01
Defects in vitamin and cofactor metabolism	20	8.81e-01	0.019400	9.56e-01
Sphingolipid metabolism	81	7.63e-01	-0.019300	9.27e-01
PKA activation in glucagon signalling	17	8.91e-01	0.019200	9.62e-01
HCMV Late Events	54	8.07e-01	-0.019200	9.32e-01
Beta-catenin independent WNT signaling	144	6.94e-01	0.019000	9.05e-01
MET promotes cell motility	29	8.61e-01	0.018800	9.53e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	9.01e-01	-0.018600	9.66e-01
SUMO E3 ligases SUMOylate target proteins	158	6.89e-01	-0.018500	9.04e-01
FGFR2b ligand binding and activation	10	9.20e-01	0.018400	9.69e-01
Early SARS-CoV-2 Infection Events	34	8.54e-01	0.018200	9.53e-01
Formation of the cornified envelope	73	7.88e-01	-0.018200	9.32e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	104	7.50e-01	-0.018100	9.20e-01
Basigin interactions	24	8.80e-01	0.017900	9.56e-01
Cytokine Signaling in Immune system	670	4.36e-01	-0.017600	7.73e-01
Metalloprotease DUBs	19	8.95e-01	0.017500	9.63e-01
Nucleotide-like (purinergic) receptors	13	9.13e-01	-0.017400	9.69e-01
RND1 GTPase cycle	41	8.48e-01	-0.017300	9.53e-01
Late SARS-CoV-2 Infection Events	67	8.07e-01	0.017300	9.32e-01
Dermatan sulfate biosynthesis	10	9.25e-01	0.017300	9.70e-01
Translation of Structural Proteins 9694635	55	8.25e-01	-0.017300	9.38e-01
Apoptotic execution phase	43	8.45e-01	-0.017200	9.51e-01
Peptide hormone biosynthesis	11	9.22e-01	0.017000	9.70e-01
AURKA Activation by TPX2	68	8.14e-01	0.016500	9.35e-01
Defective C1GALT1C1 causes TNPS	18	9.05e-01	0.016300	9.68e-01
RHOA GTPase cycle	140	7.42e-01	-0.016100	9.18e-01
Synthesis of PA	35	8.70e-01	-0.016000	9.53e-01
Metallothioneins bind metals	11	9.27e-01	-0.016000	9.71e-01
Inwardly rectifying K+ channels	35	8.70e-01	-0.016000	9.53e-01
Signaling by ERBB2 in Cancer	25	8.90e-01	-0.016000	9.62e-01
Free fatty acids regulate insulin secretion	10	9.31e-01	-0.015800	9.72e-01
RAS processing	19	9.06e-01	-0.015600	9.68e-01
Polo-like kinase mediated events	16	9.14e-01	0.015600	9.69e-01
Cellular Senescence	130	7.63e-01	0.015300	9.27e-01
Infection with Mycobacterium tuberculosis	25	8.95e-01	0.015200	9.63e-01
Mitotic Prometaphase	174	7.30e-01	0.015200	9.14e-01
MET activates RAS signaling	11	9.31e-01	-0.015000	9.72e-01
Dopamine Neurotransmitter Release Cycle	20	9.08e-01	0.015000	9.69e-01
Fc epsilon receptor (FCERI) signaling	126	7.72e-01	0.014900	9.29e-01
Mitochondrial protein import	54	8.49e-01	-0.014900	9.53e-01
FCGR activation	12	9.29e-01	-0.014900	9.72e-01
RND2 GTPase cycle	42	8.68e-01	-0.014900	9.53e-01
Presynaptic nicotinic acetylcholine receptors	12	9.29e-01	-0.014800	9.72e-01
Signaling by CSF3 (G-CSF)	28	8.93e-01	0.014700	9.62e-01
Apoptosis	164	7.48e-01	0.014500	9.20e-01
Diseases of programmed cell death	43	8.71e-01	-0.014400	9.53e-01
VEGFR2 mediated vascular permeability	26	8.99e-01	-0.014300	9.66e-01
Downstream signaling of activated FGFR3	24	9.04e-01	0.014200	9.68e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	9.36e-01	-0.013900	9.72e-01
Cell junction organization	79	8.33e-01	-0.013800	9.42e-01
Ub-specific processing proteases	153	7.70e-01	0.013700	9.29e-01
Activation of GABAB receptors	43	8.76e-01	-0.013700	9.55e-01
GABA B receptor activation	43	8.76e-01	-0.013700	9.55e-01
DNA Damage/Telomere Stress Induced Senescence	28	9.00e-01	0.013700	9.66e-01
PI-3K cascade:FGFR3	17	9.23e-01	-0.013600	9.70e-01
Recruitment of NuMA to mitotic centrosomes	75	8.41e-01	-0.013400	9.49e-01
IRS-mediated signalling	47	8.74e-01	0.013300	9.55e-01
RAC3 GTPase cycle	84	8.34e-01	-0.013200	9.43e-01
Interleukin-4 and Interleukin-13 signaling	104	8.20e-01	-0.012900	9.38e-01
Carboxyterminal post-translational modifications of tubulin	40	8.89e-01	-0.012700	9.62e-01
MHC class II antigen presentation	104	8.23e-01	0.012700	9.38e-01
Transcription of E2F targets under negative control by DREAM complex	19	9.24e-01	0.012700	9.70e-01
Diseases associated with N-glycosylation of proteins	19	9.24e-01	-0.012700	9.70e-01
Signaling by NTRK2 (TRKB)	25	9.15e-01	-0.012400	9.69e-01
Nucleotide salvage	21	9.22e-01	-0.012400	9.70e-01
Cytochrome P450 - arranged by substrate type	64	8.65e-01	-0.012300	9.53e-01
HATs acetylate histones	71	8.60e-01	0.012100	9.53e-01
HCMV Infection	79	8.53e-01	0.012000	9.53e-01
Organelle biogenesis and maintenance	243	7.49e-01	-0.011900	9.20e-01
Regulation of signaling by CBL	18	9.31e-01	0.011800	9.72e-01
O-linked glycosylation	107	8.32e-01	0.011800	9.42e-01
Activation of SMO	17	9.36e-01	-0.011200	9.72e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	31	9.17e-01	0.010800	9.69e-01
Transcriptional regulation of granulopoiesis	31	9.17e-01	-0.010700	9.69e-01
Termination of O-glycan biosynthesis	25	9.26e-01	0.010700	9.71e-01
Metabolism of lipids	696	6.35e-01	0.010500	8.77e-01
Apoptotic cleavage of cellular proteins	35	9.14e-01	-0.010500	9.69e-01
Class I MHC mediated antigen processing & presentation	361	7.31e-01	-0.010500	9.14e-01
Impaired BRCA2 binding to RAD51	33	9.17e-01	0.010400	9.69e-01
Cytoprotection by HMOX1	58	8.93e-01	0.010200	9.62e-01
tRNA processing	98	8.62e-01	-0.010100	9.53e-01
Pentose phosphate pathway	12	9.53e-01	0.009810	9.82e-01
TCR signaling	112	8.60e-01	-0.009630	9.53e-01
Toll-like Receptor Cascades	154	8.37e-01	-0.009570	9.46e-01
Glycosaminoglycan metabolism	116	8.62e-01	0.009310	9.53e-01
CRMPs in Sema3A signaling	15	9.51e-01	-0.009200	9.82e-01
Gene Silencing by RNA	80	8.89e-01	0.009050	9.62e-01
Signaling by ERBB2 KD Mutants	24	9.39e-01	-0.009000	9.74e-01
Mitotic Prophase	78	8.92e-01	-0.008930	9.62e-01
G1/S-Specific Transcription	28	9.36e-01	-0.008830	9.72e-01
Ion homeostasis	50	9.14e-01	-0.008800	9.69e-01
ISG15 antiviral mechanism	71	8.99e-01	0.008730	9.66e-01
Nuclear Receptor transcription pathway	51	9.14e-01	-0.008700	9.69e-01
Neurotransmitter release cycle	47	9.19e-01	-0.008520	9.69e-01
Metabolism of steroid hormones	33	9.33e-01	0.008410	9.72e-01
Signaling by WNT in cancer	32	9.34e-01	0.008410	9.72e-01
Transmission across Chemical Synapses	237	8.24e-01	-0.008380	9.38e-01
Signal Transduction	2410	5.03e-01	-0.008280	8.08e-01
Miscellaneous substrates	12	9.61e-01	0.008070	9.88e-01
Post NMDA receptor activation events	58	9.16e-01	0.008000	9.69e-01
CD28 dependent PI3K/Akt signaling	22	9.49e-01	-0.007920	9.81e-01
Toll Like Receptor 4 (TLR4) Cascade	135	8.75e-01	-0.007850	9.55e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	9.64e-01	-0.007820	9.89e-01
Signaling by ERBB2 TMD/JMD mutants	21	9.51e-01	-0.007710	9.82e-01
Loss of Nlp from mitotic centrosomes	65	9.16e-01	-0.007600	9.69e-01
Loss of proteins required for interphase microtubule organization from the centrosome	65	9.16e-01	-0.007600	9.69e-01
L1CAM interactions	92	9.04e-01	0.007270	9.68e-01
Synthesis of PC	27	9.50e-01	0.007020	9.81e-01
Antiviral mechanism by IFN-stimulated genes	78	9.15e-01	0.007020	9.69e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	603	7.69e-01	-0.006980	9.29e-01
Gap junction trafficking and regulation	29	9.49e-01	-0.006810	9.81e-01
RHOD GTPase cycle	48	9.36e-01	-0.006690	9.72e-01
Calcitonin-like ligand receptors	10	9.71e-01	0.006680	9.89e-01
Sema3A PAK dependent Axon repulsion	14	9.66e-01	-0.006580	9.89e-01
Removal of the Flap Intermediate from the C-strand	17	9.63e-01	-0.006540	9.89e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	101	9.10e-01	0.006510	9.69e-01
SARS-CoV-1 activates/modulates innate immune responses	37	9.45e-01	0.006500	9.80e-01
RUNX3 regulates p14-ARF	10	9.72e-01	-0.006310	9.90e-01
PRC2 methylates histones and DNA	13	9.70e-01	-0.006060	9.89e-01
SARS-CoV-2 Infection	276	8.65e-01	0.005920	9.53e-01
Integrin cell surface interactions	66	9.34e-01	-0.005920	9.72e-01
PI3K Cascade	43	9.47e-01	0.005890	9.80e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	9.70e-01	0.005710	9.89e-01
Dissolution of Fibrin Clot	13	9.72e-01	0.005590	9.90e-01
Glucocorticoid biosynthesis	10	9.76e-01	-0.005440	9.91e-01
Platelet Aggregation (Plug Formation)	37	9.55e-01	0.005350	9.84e-01
FRS-mediated FGFR3 signaling	19	9.68e-01	-0.005260	9.89e-01
RND3 GTPase cycle	41	9.56e-01	0.005020	9.84e-01
Base-Excision Repair, AP Site Formation	18	9.71e-01	0.004990	9.89e-01
Processive synthesis on the C-strand of the telomere	19	9.70e-01	-0.004990	9.89e-01
Programmed Cell Death	192	9.06e-01	-0.004940	9.68e-01
Signaling by Rho GTPases	589	8.44e-01	-0.004750	9.50e-01
Deubiquitination	226	9.08e-01	-0.004430	9.69e-01
Diseases of signal transduction by growth factor receptors and second messengers	410	8.83e-01	0.004240	9.57e-01
RET signaling	41	9.63e-01	-0.004150	9.89e-01
Activation of NMDA receptors and postsynaptic events	69	9.53e-01	0.004120	9.82e-01
RA biosynthesis pathway	22	9.74e-01	0.003980	9.90e-01
Pre-NOTCH Processing in Golgi	18	9.78e-01	-0.003780	9.92e-01
Kinesins	42	9.68e-01	0.003590	9.89e-01
SARS-CoV-2-host interactions	183	9.34e-01	0.003540	9.72e-01
Antigen processing: Ubiquitination & Proteasome degradation	293	9.18e-01	0.003490	9.69e-01
MAPK family signaling cascades	311	9.20e-01	0.003310	9.69e-01
Cleavage of the damaged pyrimidine	16	9.82e-01	0.003250	9.92e-01
Depyrimidination	16	9.82e-01	0.003250	9.92e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	9.82e-01	0.003250	9.92e-01
Glucagon-type ligand receptors	33	9.75e-01	0.003140	9.90e-01
HCMV Early Events	55	9.68e-01	-0.003120	9.89e-01
Polymerase switching on the C-strand of the telomere	24	9.79e-01	-0.003040	9.92e-01
RAF/MAP kinase cascade	264	9.44e-01	0.002530	9.78e-01
Lewis blood group biosynthesis	18	9.86e-01	-0.002450	9.93e-01
Protein ubiquitination	61	9.74e-01	-0.002410	9.90e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	181	9.58e-01	-0.002290	9.85e-01
Interaction between L1 and Ankyrins	28	9.84e-01	-0.002240	9.93e-01
Interleukin-12 signaling	43	9.80e-01	-0.002240	9.92e-01
activated TAK1 mediates p38 MAPK activation	16	9.88e-01	0.002210	9.93e-01
Role of phospholipids in phagocytosis	23	9.86e-01	-0.002180	9.93e-01
E2F mediated regulation of DNA replication	20	9.87e-01	0.002150	9.93e-01
Apoptotic cleavage of cell adhesion proteins	11	9.92e-01	-0.001740	9.95e-01
Telomere C-strand (Lagging Strand) Synthesis	32	9.87e-01	0.001690	9.93e-01
CaMK IV-mediated phosphorylation of CREB	10	9.94e-01	0.001340	9.95e-01
MAPK1/MAPK3 signaling	270	9.70e-01	0.001330	9.89e-01
Fatty acyl-CoA biosynthesis	36	9.90e-01	-0.001180	9.94e-01
Negative regulation of MET activity	20	9.93e-01	-0.001070	9.95e-01
Biological oxidations	213	9.79e-01	0.001050	9.92e-01
ECM proteoglycans	55	9.90e-01	0.000956	9.94e-01
TRAF6 mediated NF-kB activation	24	9.94e-01	0.000937	9.95e-01
Metabolism of water-soluble vitamins and cofactors	118	9.87e-01	-0.000835	9.93e-01
Platelet calcium homeostasis	27	9.94e-01	-0.000833	9.95e-01
Signaling by Interleukins	434	9.84e-01	0.000548	9.93e-01
Assembly of collagen fibrils and other multimeric structures	56	9.95e-01	-0.000521	9.95e-01

---

Detailed Gene set reports

SUMOylation of immune response proteins

SUMOylation of immune response proteins

	1198
set	SUMOylation of immune response proteins
setSize	10
pANOVA	0.00249
s.dist	0.552
p.adjustANOVA	0.0481

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PIAS3	16789
SUMO1	15514
NFKBIA	15415
IKBKE	15091
NFKB2	13895
RELA	12906
TOPORS	11451
UBE2I	10454
PIAS4	9746
SUMO3	3785

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PIAS3	16789
SUMO1	15514
NFKBIA	15415
IKBKE	15091
NFKB2	13895
RELA	12906
TOPORS	11451
UBE2I	10454
PIAS4	9746
SUMO3	3785

---

Chylomicron remodeling

Chylomicron remodeling

	206
set	Chylomicron remodeling
setSize	10
pANOVA	0.00254
s.dist	0.551
p.adjustANOVA	0.0481

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APOA2	17615
LPL	17101
APOC3	15561
APOC2	14895
APOA5	14684
APOA1	12062
GPIHBP1	10408
APOA4	10060
APOE	9123
APOB	3390

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APOA2	17615
LPL	17101
APOC3	15561
APOC2	14895
APOA5	14684
APOA1	12062
GPIHBP1	10408
APOA4	10060
APOE	9123
APOB	3390

---

SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery

	1163
set	SARS-CoV-1 modulates host translation machinery
setSize	34
pANOVA	1.73e-07
s.dist	0.518
p.adjustANOVA	9.54e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPS27A	17623
RPS14	17460
RPSA	16750
RPS27	16701
RPS28	16547
RPS16	16394
RPS10	16101
HNRNPA1	16020
RPS21	15733
RPS24	15434
RPS11	15381
RPS26	15184
RPS23	15084
RPS25	14869
RPS6	14761
RPS9	14415
RPS29	14234
RPS2	12789
RPS7	12370

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998
RPS27A	17623
RPS14	17460
RPSA	16750
RPS27	16701
RPS28	16547
RPS16	16394
RPS10	16101
HNRNPA1	16020
RPS21	15733
RPS24	15434
RPS11	15381
RPS26	15184
RPS23	15084
RPS25	14869
RPS6	14761
RPS9	14415
RPS29	14234
RPS2	12789
RPS7	12370
RPS5	11632
RPS18	11410
RPS3A	11123
RPS19	10890
RPS8	10296
RPS27L	9869
EEF1A1	9096
RPS13	7369
RPS20	7077
RPS3	5505
RPS15A	3120
RPS12	2257
RPS15	-220
FAU	-1469

---

Josephin domain DUBs

Josephin domain DUBs

	653
set	Josephin domain DUBs
setSize	11
pANOVA	0.00549
s.dist	0.483
p.adjustANOVA	0.0799

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	17623
JOSD2	17047
UBC	17042
RAD23A	15562
UBA52	15146
UBB	15063
JOSD1	12720
VCP	11557
RAD23B	4991
ATXN3	3743
PARK2	-2692

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	17623
JOSD2	17047
UBC	17042
RAD23A	15562
UBA52	15146
UBB	15063
JOSD1	12720
VCP	11557
RAD23B	4991
ATXN3	3743
PARK2	-2692

---

TRAF6 mediated IRF7 activation

TRAF6 mediated IRF7 activation

	1384
set	TRAF6 mediated IRF7 activation
setSize	26
pANOVA	3.55e-05
s.dist	-0.468
p.adjustANOVA	0.00126

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IFNA6	-7454
IFNA16	-7423
IFNA2	-7251
IFNA21	-7180
IFNA14	-7099
IFNB1	-7088
IFNA1	-7038
TRIM4	-6652
IFNA5	-5828
TANK	-5660
IFNA7	-4450
SIKE1	-4057
IFNA8	-2780
TBK1	-2417
TRIM25	-1856
DDX58	-752
EP300	381
CREBBP	955
IRF3	3496
RNF135	4528

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IFNA6	-7454
IFNA16	-7423
IFNA2	-7251
IFNA21	-7180
IFNA14	-7099
IFNB1	-7088
IFNA1	-7038
TRIM4	-6652
IFNA5	-5828
TANK	-5660
IFNA7	-4450
SIKE1	-4057
IFNA8	-2780
TBK1	-2417
TRIM25	-1856
DDX58	-752
EP300	381
CREBBP	955
IRF3	3496
RNF135	4528
IFIH1	5240
MAVS	5384
TRAF2	8353
TRAF6	9524
IKBKE	15091
IRF7	15832

---

Class C/3 (Metabotropic glutamate/pheromone receptors)

Class C/3 (Metabotropic glutamate/pheromone receptors)

	212
set	Class C/3 (Metabotropic glutamate/pheromone receptors)
setSize	39
pANOVA	6.08e-07
s.dist	-0.461
p.adjustANOVA	3.24e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAS2R46	-7339
TAS2R10	-7306
TAS2R4	-7233
TAS2R14	-6983
TAS2R50	-6656
TAS2R8	-6601
TAS2R43	-6600
TAS2R39	-6469
TAS2R13	-6411
TAS2R3	-6389
TAS2R60	-5931
TAS2R31	-5781
TAS2R30	-5769
TAS2R5	-5318
TAS2R42	-5043
GRM5	-4895
TAS2R19	-4787
TAS2R7	-4436
TAS2R16	-4099
TAS2R1	-3267

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAS2R46	-7339
TAS2R10	-7306
TAS2R4	-7233
TAS2R14	-6983
TAS2R50	-6656
TAS2R8	-6601
TAS2R43	-6600
TAS2R39	-6469
TAS2R13	-6411
TAS2R3	-6389
TAS2R60	-5931
TAS2R31	-5781
TAS2R30	-5769
TAS2R5	-5318
TAS2R42	-5043
GRM5	-4895
TAS2R19	-4787
TAS2R7	-4436
TAS2R16	-4099
TAS2R1	-3267
TAS2R38	-2766
TAS1R2	-767
TAS2R20	-749
TAS2R9	481
GRM7	954
CASR	1209
GRM8	1491
GRM1	2427
GABBR1	5279
TAS1R3	5729
GRM2	5849
GABBR2	6454
TAS2R40	7295
GRM6	7787
GRM4	8862
GPRC6A	9013
TAS2R41	9019
GRM3	12208
TAS1R1	16838

---

Pexophagy

Pexophagy

	910
set	Pexophagy
setSize	11
pANOVA	0.00889
s.dist	0.455
p.adjustANOVA	0.113

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
PEX5	17036
MAP1LC3B	15762
UBA52	15146
UBB	15063
NBR1	14839
ATM	10689
SQSTM1	5152
EPAS1	-2163
USP30	-2346

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
PEX5	17036
MAP1LC3B	15762
UBA52	15146
UBB	15063
NBR1	14839
ATM	10689
SQSTM1	5152
EPAS1	-2163
USP30	-2346

---

Phase 4 - resting membrane potential

Phase 4 - resting membrane potential

	913
set	Phase 4 - resting membrane potential
setSize	19
pANOVA	0.0011
s.dist	0.432
p.adjustANOVA	0.027

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KCNK16	17421
KCNJ4	16930
KCNK18	16819
KCNJ12	16370
KCNK15	15074
KCNK6	14501
KCNK7	13732
KCNJ14	12733
KCNK17	12557
KCNK10	11671
KCNK4	10547
KCNK12	9301
KCNK3	9192
KCNK5	8778
KCNK9	8381
KCNJ2	7972
KCNK1	4007
KCNK13	1366
KCNK2	866

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KCNK16	17421
KCNJ4	16930
KCNK18	16819
KCNJ12	16370
KCNK15	15074
KCNK6	14501
KCNK7	13732
KCNJ14	12733
KCNK17	12557
KCNK10	11671
KCNK4	10547
KCNK12	9301
KCNK3	9192
KCNK5	8778
KCNK9	8381
KCNJ2	7972
KCNK1	4007
KCNK13	1366
KCNK2	866

---

Interaction With Cumulus Cells And The Zona Pellucida

Interaction With Cumulus Cells And The Zona Pellucida

	614
set	Interaction With Cumulus Cells And The Zona Pellucida
setSize	11
pANOVA	0.0143
s.dist	-0.426
p.adjustANOVA	0.153

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADAM20	-6401
SPAM1	-6352
ADAM2	-4855
ADAM21	-4386
B4GALT1	-1620
ZP4	-1539
OVGP1	-444
ZP2	2669
ADAM30	3126
ZP3	7641
ZP1	11219

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADAM20	-6401
SPAM1	-6352
ADAM2	-4855
ADAM21	-4386
B4GALT1	-1620
ZP4	-1539
OVGP1	-444
ZP2	2669
ADAM30	3126
ZP3	7641
ZP1	11219

---

Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors

	399
set	Expression and translocation of olfactory receptors
setSize	358
pANOVA	3.01e-42
s.dist	-0.418
p.adjustANOVA	4.65e-39

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR2A12	-7381
OR7E24	-7370
OR8U1	-7368
OR52A5	-7357
OR52D1	-7353
OR4Q3	-7352
OR13C8	-7292
OR10H3	-7285
OR52E4	-7279
OR5K1	-7254
OR8B2	-7245
OR4N4	-7225
OR8H1	-7216
OR6C1	-7212
OR2G6	-7211
OR5AC2	-7206
OR51G2	-7199
OR5T2	-7182
OR4D5	-7160
OR2W3	-7151

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR2A12	-7381.0
OR7E24	-7370.0
OR8U1	-7368.0
OR52A5	-7357.0
OR52D1	-7353.0
OR4Q3	-7352.0
OR13C8	-7292.0
OR10H3	-7285.0
OR52E4	-7279.0
OR5K1	-7254.0
OR8B2	-7245.0
OR4N4	-7225.0
OR8H1	-7216.0
OR6C1	-7212.0
OR2G6	-7211.0
OR5AC2	-7206.0
OR51G2	-7199.0
OR5T2	-7182.0
OR4D5	-7160.0
OR2W3	-7151.0
OR1J2	-7147.0
OR2G3	-7137.0
OR8D1	-7128.0
OR5K2	-7124.0
OR5P2	-7115.0
OR5K4	-7106.0
OR2T33	-7059.0
OR5B12	-7058.0
OR4F15	-7048.0
OR4E2	-7013.0
OR2B6	-7012.0
OR6Q1	-7011.0
OR7G2	-6985.0
OR52H1	-6976.0
OR6M1	-6975.0
OR11G2	-6970.0
OR13F1	-6959.0
OR10G9	-6944.0
OR52I2	-6940.0
OR8I2	-6922.0
OR51I1	-6895.0
OR2K2	-6891.0
OR7D4	-6884.0
OR5K3	-6882.0
OR5AP2	-6877.0
OR6C2	-6858.0
OR9G1	-6835.5
OR9G9	-6835.5
OR4C45	-6834.0
OR5D18	-6810.0
OR13C4	-6790.0
OR14A16	-6781.0
OR12D2	-6765.0
OR51B6	-6753.0
OR5F1	-6736.0
OR2B3	-6721.0
OR8D2	-6714.0
OR52I1	-6682.0
OR10K2	-6671.0
OR5AK2	-6666.0
OR1S1	-6615.0
OR13C2	-6588.0
OR6K6	-6556.0
OR2A2	-6552.0
OR5AN1	-6525.0
OR10J1	-6509.0
OR4K14	-6507.0
OR6C75	-6488.0
OR10J5	-6486.0
OR10G8	-6474.0
OR56A1	-6409.0
OR8K3	-6403.0
OR13G1	-6377.0
OR1Q1	-6372.0
OR2T10	-6350.0
OR2M5	-6345.0
OR13C3	-6339.0
OR5P3	-6333.0
OR10W1	-6317.0
OR4N5	-6306.0
OR5AS1	-6278.0
OR5H1	-6252.0
OR10G4	-6218.0
OR6C6	-6213.0
OR6N2	-6200.0
OR10Q1	-6180.0
OR8U8	-6153.0
OR51V1	-6140.0
OR8H2	-6098.0
OR5M9	-6090.0
OR6C3	-6089.0
OR4B1	-6088.0
OR1J1	-6071.0
OR5D14	-6062.0
OR5L2	-6055.0
OR4C46	-5996.0
OR6B1	-5960.0
OR2A14	-5920.0
OR52E6	-5900.0
OR4D10	-5889.0
OR11A1	-5871.0
OR6C74	-5838.0
OR6C4	-5836.0
OR5W2	-5825.0
OR2W1	-5811.0
OR8H3	-5790.0
OR3A2	-5776.0
OR7A10	-5772.0
OR2M4	-5748.0
OR5M11	-5726.0
OR51I2	-5649.0
OR51A7	-5647.0
OR5M10	-5630.0
OR5H2	-5605.0
OR9G4	-5594.0
OR5D16	-5563.0
OR2D3	-5546.0
OR1K1	-5497.0
OR6F1	-5459.0
OR1L3	-5413.0
OR11H4	-5359.0
OR4A16	-5356.0
OR52N2	-5327.0
OR51B5	-5325.0
OR5B3	-5286.0
OR2AK2	-5177.0
OR4P4	-5158.0
OR4M1	-5143.0
OR8J3	-5140.0
OR10A6	-5124.0
OR8J1	-5121.0
OR1A2	-5098.0
OR4C13	-5097.0
OR2T1	-5034.0
OR2J2	-5002.0
OR1A1	-4982.0
OR1N2	-4924.0
OR4K13	-4922.0
OR4D1	-4911.0
OR8A1	-4865.0
OR52M1	-4652.0
OR2T8	-4611.0
OR10A4	-4558.0
OR10AD1	-4545.0
OR52E8	-4542.0
OR4A47	-4495.0
OR6B3	-4493.0
OR5M8	-4482.0
OR1E1	-4435.0
OR6A2	-4158.0
OR2Y1	-4123.0
OR5M3	-4106.0
OR52A1	-4101.0
OR52B6	-4041.0
OR9A2	-4028.0
OR5T3	-3979.0
OR5M1	-3966.0
OR7G1	-3955.0
OR4C12	-3940.0
OR6C70	-3937.0
OR10A7	-3934.0
OR2T34	-3916.0
OR6C76	-3912.0
OR6T1	-3825.0
OR8S1	-3730.0
OR2L8	-3715.0
OR2H1	-3700.0
OR2AG1	-3691.0
OR3A1	-3664.0
OR5H6	-3651.0
OR10G3	-3640.0
OR52K2	-3629.0
OR1I1	-3613.0
OR4C6	-3499.0
OR51L1	-3475.0
OR10G7	-3459.0
OR51E2	-3430.0
OR4K17	-3422.0
OR2L5	-3421.0
OR2B2	-3311.0
OR10G2	-3176.0
OR8K1	-3167.0
OR51A2	-3135.0
OR8G1	-3112.0
OR10H1	-3075.0
OR51F2	-3040.0
OR2L13	-2985.0
OR2T6	-2956.0
OR52N1	-2928.0
OR4D11	-2894.0
OR4N2	-2891.0
OR10AG1	-2553.0
OR52R1	-2519.0
OR1B1	-2477.0
OR2J3	-2412.0
OR5V1	-2284.0
OR51T1	-2207.0
OR51B4	-2171.0
OR4K1	-2153.0
OR14C36	-2066.0
OR4D9	-1979.0
OR2G2	-1911.0
OR51B2	-1813.0
OR4X2	-1674.0
OR5B2	-1670.0
OR2M3	-1627.0
OR10S1	-1558.0
OR2T3	-1489.0
OR5H15	-1427.0
OR6P1	-1408.0
OR7A5	-1357.0
OR4F6	-1282.0
OR5C1	-1268.0
OR10A3	-1203.0
OR9Q1	-1199.0
OR6C65	-1188.0
OR1J4	-1182.0
OR2T4	-1063.0
OR56A3	-1024.0
OR2F1	-957.0
OR5T1	-950.0
OR6S1	-839.0
OR5R1	-770.0
OR6X1	-670.0
OR7C1	-596.0
OR1C1	-469.0
OR10H4	-416.0
OR7D2	-245.0
OR10C1	189.0
REEP1	222.0
OR51D1	350.0
OR4D6	393.0
OR14I1	439.0
OR52E2	529.0
OR5AU1	826.0
OR1L6	884.0
OR5A1	981.0
OR56A4	1233.0
OR12D3	1425.0
OR52N5	1434.0
OR4K15	1581.0
OR1M1	1617.0
OR5I1	1930.0
OR52K1	2152.0
OR7A17	2227.0
OR52J3	2294.0
OR8B12	2362.0
OR4S2	2386.0
OR6Y1	2477.0
OR4K2	2788.0
OR9K2	2795.0
OR2L3	2808.0
OR7C2	2904.0
OR14J1	2966.0
OR10T2	3085.0
OR2C1	3091.0
OR6V1	3199.0
OR4D2	3275.0
OR13C9	3403.0
OR1E2	3635.0
OR11L1	3856.0
OR2AG2	3965.0
OR11H6	3984.0
OR8D4	4764.0
OR1L8	4766.0
OR4L1	4792.0
OR8G5	4800.0
OR6B2	5006.0
EBF1	5132.0
OR2A25	5362.0
OR5D13	5440.0
OR5B17	5595.0
OR4C3	5647.0
OR56A5	5830.0
OR13J1	5895.0
OR2Z1	6091.0
OR9Q2	6260.0
OR9I1	6545.0
OR4K5	6553.0
OR2M7	6606.0
OR51M1	6711.0
OR6K2	6910.0
OR2D2	6931.0
OR2AT4	7019.0
RTP1	7037.0
OR2H2	7205.0
OR4M2	7432.0
OR51S1	7615.0
OR2T27	7636.0
OR4C15	7930.0
OR10A5	8093.0
OR51E1	8132.0
OR2T11	8306.0
OR1L4	8788.0
OR2W5	8872.0
OR10K1	8931.0
OR1D2	9324.0
OR10X1	9650.0
OR4X1	10189.0
OR8K5	10313.0
OR1N1	10825.0
OR2S2	10832.0
OR10A2	10874.0
OR52L1	11054.0
OR1L1	11223.0
OR2V2	11274.0
OR2F2	11301.0
OR1F1	11439.0
OR5J2	11629.0
OR2AE1	11641.0
OR5A2	12082.0
LHX2	12100.0
OR11H2	12259.0
OR9A4	12413.0
OR51G1	12446.0
OR1G1	12459.0
OR4S1	12547.0
OR3A3	12685.0
LDB1	12794.0
OR8B4	12984.0
OR10H5	13076.0
OR4A15	13189.0
OR13A1	13331.0
OR10Z1	13351.0
OR2B11	13393.0
OR52W1	13423.0
OR5B21	13461.0
OR10J3	13598.0
OR2C3	13675.0
OR6N1	13782.0
OR4A5	14912.0
OR4C16	14952.0
OR10P1	15124.0
OR2L2	15471.0
OR1S2	15520.0
OR5L1	15697.0
OR51A4	15799.0
OR6K3	15979.0
OR5AR1	16000.0
OR56B1	16282.0
OR2V1	16351.0
OR10R2	16396.0
OR52B2	16410.0
OR2M2	16490.0
OR10H2	16512.0
OR10V1	16587.0
OR51F1	16686.0
OR8B8	16831.0
OR51Q1	16994.0
OR2AP1	17117.0
RTP2	17287.0
OR6C68	17620.0
OR56B4	17811.0
OR2A5	17820.0
OR8G2	18086.0
OR13D1	18192.0
OR4C11	18210.0
OR7G3	18227.0

---

NF-kB is activated and signals survival

NF-kB is activated and signals survival

	778
set	NF-kB is activated and signals survival
setSize	12
pANOVA	0.0125
s.dist	0.416
p.adjustANOVA	0.142

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
NFKBIA	15415
UBA52	15146
UBB	15063
RELA	12906
TRAF6	9524
NGF	8768
NGFR	7653
IKBKB	7359
SQSTM1	5152
NFKB1	-2596

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
NFKBIA	15415
UBA52	15146
UBB	15063
RELA	12906
TRAF6	9524
NGF	8768
NGFR	7653
IKBKB	7359
SQSTM1	5152
NFKB1	-2596

---

Peptide chain elongation

Peptide chain elongation

	903
set	Peptide chain elongation
setSize	84
pANOVA	6.63e-11
s.dist	0.412
p.adjustANOVA	1.28e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPL35A	17964
RPS27A	17623
RPL34	17570
RPS14	17460
RPL27	17419
RPL18A	17406
RPSA	16750
RPS27	16701
RPS28	16547
RPL32	16401
RPS16	16394
RPL28	16373
RPS10	16101
EEF2	15877
RPL7	15788
RPS21	15733
RPL29	15716
RPL10L	15577
RPL17	15487

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPL35A	17964.0
RPS27A	17623.0
RPL34	17570.0
RPS14	17460.0
RPL27	17419.0
RPL18A	17406.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPL32	16401.0
RPS16	16394.0
RPL28	16373.0
RPS10	16101.0
EEF2	15877.0
RPL7	15788.0
RPS21	15733.0
RPL29	15716.0
RPL10L	15577.0
RPL17	15487.0
RPS24	15434.0
RPL23	15404.0
RPS11	15381.0
RPL38	15324.0
RPS26	15184.0
UBA52	15146.0
RPS23	15084.0
RPL24	14927.0
RPS25	14869.0
RPS6	14761.0
RPL9	14519.0
RPS9	14415.0
RPS29	14234.0
RPL26L1	14132.0
RPL30	13945.0
RPL14	13883.0
RPL26	13496.0
RPL7A	13425.0
RPS2	12789.0
RPL12	12744.0
RPL41	12555.0
RPS7	12370.0
RPL37A	11838.0
RPL3L	11730.0
RPS5	11632.0
RPS18	11410.0
RPL13A	11201.5
RPS3A	11123.0
RPL19	10992.0
RPS19	10890.0
RPL13	10808.0
RPS8	10296.0
RPS27L	9869.0
RPL39L	9655.0
RPL18	9621.0
EEF1A1	9096.0
RPL23A	8852.0
RPLP1	8689.0
RPLP2	8239.0
RPL37	7695.0
RPS13	7369.0
RPL36AL	7147.0
RPS20	7077.0
RPL4	6779.0
RPL36	6145.0
RPS3	5505.0
RPL8	5310.0
RPL10A	5072.0
RPL15	4446.0
RPL3	4267.0
RPLP0	3455.0
RPS15A	3120.0
RPL11	2419.0
RPS12	2257.0
RPL27A	1306.0
RPL22	1272.0
RPL5	852.0
RPL31	733.0
RPL35	467.0
RPS15	-220.0
RPL21	-682.0
FAU	-1469.0
RPL22L1	-1702.0
RPL6	-4235.0

---

Regulation of NF-kappa B signaling

Regulation of NF-kappa B signaling

	1091
set	Regulation of NF-kappa B signaling
setSize	17
pANOVA	0.00341
s.dist	0.41
p.adjustANOVA	0.0593

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
UBA52	15146
LRRC14	15139
UBB	15063
USP18	14882
IKBIP	12610
NLRX1	12126
TP53	11464
NLRC5	9936
TRAF6	9524
USP14	8938
TRAF2	8353
IKBKB	7359
CASP8	7096
N4BP1	1599
CHUK	-2452

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
UBA52	15146
LRRC14	15139
UBB	15063
USP18	14882
IKBIP	12610
NLRX1	12126
TP53	11464
NLRC5	9936
TRAF6	9524
USP14	8938
TRAF2	8353
IKBKB	7359
CASP8	7096
N4BP1	1599
CHUK	-2452

---

Olfactory Signaling Pathway

Olfactory Signaling Pathway

	853
set	Olfactory Signaling Pathway
setSize	365
pANOVA	3.28e-41
s.dist	-0.409
p.adjustANOVA	2.53e-38

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR2A12	-7381
OR7E24	-7370
OR8U1	-7368
OR52A5	-7357
OR52D1	-7353
OR4Q3	-7352
OR13C8	-7292
OR10H3	-7285
OR52E4	-7279
OR5K1	-7254
OR8B2	-7245
OR4N4	-7225
OR8H1	-7216
OR6C1	-7212
OR2G6	-7211
OR5AC2	-7206
OR51G2	-7199
OR5T2	-7182
OR4D5	-7160
OR2W3	-7151

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR2A12	-7381.0
OR7E24	-7370.0
OR8U1	-7368.0
OR52A5	-7357.0
OR52D1	-7353.0
OR4Q3	-7352.0
OR13C8	-7292.0
OR10H3	-7285.0
OR52E4	-7279.0
OR5K1	-7254.0
OR8B2	-7245.0
OR4N4	-7225.0
OR8H1	-7216.0
OR6C1	-7212.0
OR2G6	-7211.0
OR5AC2	-7206.0
OR51G2	-7199.0
OR5T2	-7182.0
OR4D5	-7160.0
OR2W3	-7151.0
OR1J2	-7147.0
OR2G3	-7137.0
OR8D1	-7128.0
OR5K2	-7124.0
OR5P2	-7115.0
OR5K4	-7106.0
OR2T33	-7059.0
OR5B12	-7058.0
OR4F15	-7048.0
OR4E2	-7013.0
OR2B6	-7012.0
OR6Q1	-7011.0
OR7G2	-6985.0
OR52H1	-6976.0
OR6M1	-6975.0
OR11G2	-6970.0
OR13F1	-6959.0
OR10G9	-6944.0
OR52I2	-6940.0
OR8I2	-6922.0
OR51I1	-6895.0
OR2K2	-6891.0
OR7D4	-6884.0
OR5K3	-6882.0
OR5AP2	-6877.0
OR6C2	-6858.0
OR9G1	-6835.5
OR9G9	-6835.5
OR4C45	-6834.0
OR5D18	-6810.0
OR13C4	-6790.0
OR14A16	-6781.0
OR12D2	-6765.0
OR51B6	-6753.0
OR5F1	-6736.0
OR2B3	-6721.0
OR8D2	-6714.0
OR52I1	-6682.0
OR10K2	-6671.0
OR5AK2	-6666.0
OR1S1	-6615.0
OR13C2	-6588.0
OR6K6	-6556.0
OR2A2	-6552.0
OR5AN1	-6525.0
OR10J1	-6509.0
OR4K14	-6507.0
OR6C75	-6488.0
OR10J5	-6486.0
OR10G8	-6474.0
OR56A1	-6409.0
OR8K3	-6403.0
OR13G1	-6377.0
OR1Q1	-6372.0
OR2T10	-6350.0
OR2M5	-6345.0
OR13C3	-6339.0
OR5P3	-6333.0
OR10W1	-6317.0
OR4N5	-6306.0
OR5AS1	-6278.0
OR5H1	-6252.0
OR10G4	-6218.0
OR6C6	-6213.0
OR6N2	-6200.0
OR10Q1	-6180.0
OR8U8	-6153.0
OR51V1	-6140.0
OR8H2	-6098.0
OR5M9	-6090.0
OR6C3	-6089.0
OR4B1	-6088.0
OR1J1	-6071.0
OR5D14	-6062.0
OR5L2	-6055.0
OR4C46	-5996.0
OR6B1	-5960.0
OR2A14	-5920.0
OR52E6	-5900.0
OR4D10	-5889.0
OR11A1	-5871.0
OR6C74	-5838.0
OR6C4	-5836.0
OR5W2	-5825.0
OR2W1	-5811.0
OR8H3	-5790.0
OR3A2	-5776.0
OR7A10	-5772.0
OR2M4	-5748.0
OR5M11	-5726.0
OR51I2	-5649.0
OR51A7	-5647.0
OR5M10	-5630.0
OR5H2	-5605.0
OR9G4	-5594.0
OR5D16	-5563.0
OR2D3	-5546.0
OR1K1	-5497.0
OR6F1	-5459.0
OR1L3	-5413.0
OR11H4	-5359.0
OR4A16	-5356.0
OR52N2	-5327.0
OR51B5	-5325.0
OR5B3	-5286.0
OR2AK2	-5177.0
OR4P4	-5158.0
OR4M1	-5143.0
OR8J3	-5140.0
OR10A6	-5124.0
OR8J1	-5121.0
OR1A2	-5098.0
OR4C13	-5097.0
OR2T1	-5034.0
OR2J2	-5002.0
OR1A1	-4982.0
OR1N2	-4924.0
OR4K13	-4922.0
OR4D1	-4911.0
OR8A1	-4865.0
OR52M1	-4652.0
OR2T8	-4611.0
OR10A4	-4558.0
OR10AD1	-4545.0
OR52E8	-4542.0
OR4A47	-4495.0
OR6B3	-4493.0
OR5M8	-4482.0
OR1E1	-4435.0
OR6A2	-4158.0
OR2Y1	-4123.0
OR5M3	-4106.0
OR52A1	-4101.0
GNG13	-4054.0
OR52B6	-4041.0
OR9A2	-4028.0
OR5T3	-3979.0
OR5M1	-3966.0
OR7G1	-3955.0
OR4C12	-3940.0
OR6C70	-3937.0
OR10A7	-3934.0
OR2T34	-3916.0
OR6C76	-3912.0
OR6T1	-3825.0
OR8S1	-3730.0
OR2L8	-3715.0
OR2H1	-3700.0
OR2AG1	-3691.0
OR3A1	-3664.0
OR5H6	-3651.0
OR10G3	-3640.0
OR52K2	-3629.0
OR1I1	-3613.0
OR4C6	-3499.0
OR51L1	-3475.0
OR10G7	-3459.0
OR51E2	-3430.0
OR4K17	-3422.0
OR2L5	-3421.0
OR2B2	-3311.0
OR10G2	-3176.0
OR8K1	-3167.0
OR51A2	-3135.0
OR8G1	-3112.0
OR10H1	-3075.0
OR51F2	-3040.0
OR2L13	-2985.0
OR2T6	-2956.0
OR52N1	-2928.0
OR4D11	-2894.0
OR4N2	-2891.0
OR10AG1	-2553.0
OR52R1	-2519.0
OR1B1	-2477.0
OR2J3	-2412.0
OR5V1	-2284.0
OR51T1	-2207.0
OR51B4	-2171.0
OR4K1	-2153.0
OR14C36	-2066.0
OR4D9	-1979.0
OR2G2	-1911.0
OR51B2	-1813.0
OR4X2	-1674.0
OR5B2	-1670.0
OR2M3	-1627.0
OR10S1	-1558.0
OR2T3	-1489.0
OR5H15	-1427.0
OR6P1	-1408.0
OR7A5	-1357.0
OR4F6	-1282.0
OR5C1	-1268.0
OR10A3	-1203.0
OR9Q1	-1199.0
OR6C65	-1188.0
OR1J4	-1182.0
OR2T4	-1063.0
OR56A3	-1024.0
OR2F1	-957.0
OR5T1	-950.0
OR6S1	-839.0
OR5R1	-770.0
OR6X1	-670.0
OR7C1	-596.0
OR1C1	-469.0
OR10H4	-416.0
OR7D2	-245.0
OR10C1	189.0
REEP1	222.0
OR51D1	350.0
OR4D6	393.0
OR14I1	439.0
OR52E2	529.0
OR5AU1	826.0
OR1L6	884.0
OR5A1	981.0
OR56A4	1233.0
OR12D3	1425.0
OR52N5	1434.0
OR4K15	1581.0
OR1M1	1617.0
OR5I1	1930.0
ANO2	2111.0
OR52K1	2152.0
OR7A17	2227.0
OR52J3	2294.0
OR8B12	2362.0
OR4S2	2386.0
OR6Y1	2477.0
GNB1	2634.0
OR4K2	2788.0
OR9K2	2795.0
OR2L3	2808.0
OR7C2	2904.0
OR14J1	2966.0
OR10T2	3085.0
OR2C1	3091.0
OR6V1	3199.0
OR4D2	3275.0
OR13C9	3403.0
OR1E2	3635.0
OR11L1	3856.0
OR2AG2	3965.0
OR11H6	3984.0
OR8D4	4764.0
OR1L8	4766.0
OR4L1	4792.0
OR8G5	4800.0
OR6B2	5006.0
EBF1	5132.0
OR2A25	5362.0
OR5D13	5440.0
OR5B17	5595.0
OR4C3	5647.0
OR56A5	5830.0
OR13J1	5895.0
OR2Z1	6091.0
OR9Q2	6260.0
OR9I1	6545.0
OR4K5	6553.0
OR2M7	6606.0
OR51M1	6711.0
OR6K2	6910.0
GNAL	6927.0
OR2D2	6931.0
OR2AT4	7019.0
RTP1	7037.0
OR2H2	7205.0
OR4M2	7432.0
OR51S1	7615.0
OR2T27	7636.0
OR4C15	7930.0
OR10A5	8093.0
OR51E1	8132.0
OR2T11	8306.0
OR1L4	8788.0
OR2W5	8872.0
OR10K1	8931.0
OR1D2	9324.0
OR10X1	9650.0
ADCY3	9770.0
OR4X1	10189.0
OR8K5	10313.0
OR1N1	10825.0
OR2S2	10832.0
OR10A2	10874.0
OR52L1	11054.0
OR1L1	11223.0
OR2V2	11274.0
OR2F2	11301.0
OR1F1	11439.0
OR5J2	11629.0
OR2AE1	11641.0
OR5A2	12082.0
LHX2	12100.0
CNGA4	12115.0
OR11H2	12259.0
OR9A4	12413.0
OR51G1	12446.0
OR1G1	12459.0
OR4S1	12547.0
OR3A3	12685.0
LDB1	12794.0
OR8B4	12984.0
OR10H5	13076.0
OR4A15	13189.0
OR13A1	13331.0
OR10Z1	13351.0
OR2B11	13393.0
OR52W1	13423.0
OR5B21	13461.0
OR10J3	13598.0
OR2C3	13675.0
OR6N1	13782.0
CNGB1	14697.0
OR4A5	14912.0
OR4C16	14952.0
OR10P1	15124.0
OR2L2	15471.0
OR1S2	15520.0
OR5L1	15697.0
OR51A4	15799.0
OR6K3	15979.0
OR5AR1	16000.0
OR56B1	16282.0
OR2V1	16351.0
OR10R2	16396.0
OR52B2	16410.0
OR2M2	16490.0
OR10H2	16512.0
OR10V1	16587.0
OR51F1	16686.0
OR8B8	16831.0
OR51Q1	16994.0
OR2AP1	17117.0
RTP2	17287.0
OR6C68	17620.0
OR56B4	17811.0
OR2A5	17820.0
OR8G2	18086.0
OR13D1	18192.0
OR4C11	18210.0
OR7G3	18227.0

---

Viral mRNA Translation

Viral mRNA Translation

	1496
set	Viral mRNA Translation
setSize	84
pANOVA	1.32e-10
s.dist	0.405
p.adjustANOVA	2.06e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPL35A	17964
RPS27A	17623
RPL34	17570
RPS14	17460
RPL27	17419
RPL18A	17406
RPSA	16750
RPS27	16701
RPS28	16547
RPL32	16401
RPS16	16394
RPL28	16373
RPS10	16101
RPL7	15788
RPS21	15733
RPL29	15716
RPL10L	15577
RPL17	15487
RPS24	15434

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPL35A	17964.0
RPS27A	17623.0
RPL34	17570.0
RPS14	17460.0
RPL27	17419.0
RPL18A	17406.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPL32	16401.0
RPS16	16394.0
RPL28	16373.0
RPS10	16101.0
RPL7	15788.0
RPS21	15733.0
RPL29	15716.0
RPL10L	15577.0
RPL17	15487.0
RPS24	15434.0
RPL23	15404.0
RPS11	15381.0
RPL38	15324.0
RPS26	15184.0
UBA52	15146.0
RPS23	15084.0
RPL24	14927.0
RPS25	14869.0
RPS6	14761.0
RPL9	14519.0
RPS9	14415.0
RPS29	14234.0
RPL26L1	14132.0
RPL30	13945.0
RPL14	13883.0
RPL26	13496.0
RPL7A	13425.0
RPS2	12789.0
RPL12	12744.0
RPL41	12555.0
RPS7	12370.0
RPL37A	11838.0
RPL3L	11730.0
RPS5	11632.0
RPS18	11410.0
RPL13A	11201.5
RPS3A	11123.0
RPL19	10992.0
RPS19	10890.0
RPL13	10808.0
RPS8	10296.0
RPS27L	9869.0
RPL39L	9655.0
RPL18	9621.0
GRSF1	9256.0
RPL23A	8852.0
RPLP1	8689.0
DNAJC3	8665.0
RPLP2	8239.0
RPL37	7695.0
RPS13	7369.0
RPL36AL	7147.0
RPS20	7077.0
RPL4	6779.0
RPL36	6145.0
RPS3	5505.0
RPL8	5310.0
RPL10A	5072.0
RPL15	4446.0
RPL3	4267.0
RPLP0	3455.0
RPS15A	3120.0
RPL11	2419.0
RPS12	2257.0
RPL27A	1306.0
RPL22	1272.0
RPL5	852.0
RPL31	733.0
RPL35	467.0
RPS15	-220.0
RPL21	-682.0
FAU	-1469.0
RPL22L1	-1702.0
RPL6	-4235.0

---

APC/C:Cdc20 mediated degradation of Cyclin B

APC/C:Cdc20 mediated degradation of Cyclin B

	13
set	APC/C:Cdc20 mediated degradation of Cyclin B
setSize	24
pANOVA	0.000662
s.dist	0.401
p.adjustANOVA	0.018

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
ANAPC15	16288
UBE2S	15864
CDC20	15528
UBA52	15146
UBB	15063
CDK1	14620
ANAPC7	13840
ANAPC11	13372
ANAPC10	12673
CDC23	12635
ANAPC1	12119
ANAPC2	11107
ANAPC4	10052
UBE2C	7012
CCNB1	6871
CDC16	5961
ANAPC16	5542
UBE2D1	4603

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
ANAPC15	16288
UBE2S	15864
CDC20	15528
UBA52	15146
UBB	15063
CDK1	14620
ANAPC7	13840
ANAPC11	13372
ANAPC10	12673
CDC23	12635
ANAPC1	12119
ANAPC2	11107
ANAPC4	10052
UBE2C	7012
CCNB1	6871
CDC16	5961
ANAPC16	5542
UBE2D1	4603
ANAPC5	3493
UBE2E1	2742
CDC26	2559
CDC27	1689

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	397
set	Eukaryotic Translation Termination
setSize	87
pANOVA	1.35e-10
s.dist	0.398
p.adjustANOVA	2.06e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPL35A	17964
APEH	17849
RPS27A	17623
RPL34	17570
RPS14	17460
RPL27	17419
RPL18A	17406
RPSA	16750
RPS27	16701
RPS28	16547
RPL32	16401
RPS16	16394
RPL28	16373
RPS10	16101
RPL7	15788
RPS21	15733
RPL29	15716
RPL10L	15577
RPL17	15487

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPL35A	17964.0
APEH	17849.0
RPS27A	17623.0
RPL34	17570.0
RPS14	17460.0
RPL27	17419.0
RPL18A	17406.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPL32	16401.0
RPS16	16394.0
RPL28	16373.0
RPS10	16101.0
RPL7	15788.0
RPS21	15733.0
RPL29	15716.0
RPL10L	15577.0
RPL17	15487.0
RPS24	15434.0
RPL23	15404.0
RPS11	15381.0
RPL38	15324.0
RPS26	15184.0
UBA52	15146.0
RPS23	15084.0
RPL24	14927.0
RPS25	14869.0
RPS6	14761.0
RPL9	14519.0
RPS9	14415.0
RPS29	14234.0
RPL26L1	14132.0
RPL30	13945.0
RPL14	13883.0
RPL26	13496.0
RPL7A	13425.0
RPS2	12789.0
RPL12	12744.0
RPL41	12555.0
RPS7	12370.0
RPL37A	11838.0
RPL3L	11730.0
N6AMT1	11698.0
RPS5	11632.0
RPS18	11410.0
RPL13A	11201.5
RPS3A	11123.0
RPL19	10992.0
RPS19	10890.0
RPL13	10808.0
RPS8	10296.0
RPS27L	9869.0
RPL39L	9655.0
RPL18	9621.0
RPL23A	8852.0
RPLP1	8689.0
RPLP2	8239.0
RPL37	7695.0
RPS13	7369.0
RPL36AL	7147.0
RPS20	7077.0
RPL4	6779.0
RPL36	6145.0
RPS3	5505.0
RPL8	5310.0
RPL10A	5072.0
ETF1	4788.0
RPL15	4446.0
RPL3	4267.0
GSPT1	4234.0
RPLP0	3455.0
RPS15A	3120.0
TRMT112	3046.0
RPL11	2419.0
RPS12	2257.0
RPL27A	1306.0
RPL22	1272.0
RPL5	852.0
RPL31	733.0
RPL35	467.0
RPS15	-220.0
RPL21	-682.0
FAU	-1469.0
RPL22L1	-1702.0
RPL6	-4235.0

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	395
set	Eukaryotic Translation Elongation
setSize	88
pANOVA	1.47e-10
s.dist	0.395
p.adjustANOVA	2.06e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPL35A	17964
RPS27A	17623
RPL34	17570
RPS14	17460
RPL27	17419
RPL18A	17406
RPSA	16750
RPS27	16701
RPS28	16547
RPL32	16401
RPS16	16394
RPL28	16373
RPS10	16101
EEF2	15877
RPL7	15788
RPS21	15733
RPL29	15716
RPL10L	15577
RPL17	15487

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPL35A	17964.0
RPS27A	17623.0
RPL34	17570.0
RPS14	17460.0
RPL27	17419.0
RPL18A	17406.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPL32	16401.0
RPS16	16394.0
RPL28	16373.0
RPS10	16101.0
EEF2	15877.0
RPL7	15788.0
RPS21	15733.0
RPL29	15716.0
RPL10L	15577.0
RPL17	15487.0
RPS24	15434.0
RPL23	15404.0
RPS11	15381.0
RPL38	15324.0
RPS26	15184.0
UBA52	15146.0
RPS23	15084.0
RPL24	14927.0
RPS25	14869.0
RPS6	14761.0
RPL9	14519.0
RPS9	14415.0
RPS29	14234.0
RPL26L1	14132.0
RPL30	13945.0
RPL14	13883.0
RPL26	13496.0
RPL7A	13425.0
RPS2	12789.0
RPL12	12744.0
RPL41	12555.0
RPS7	12370.0
RPL37A	11838.0
RPL3L	11730.0
RPS5	11632.0
RPS18	11410.0
RPL13A	11201.5
RPS3A	11123.0
RPL19	10992.0
RPS19	10890.0
RPL13	10808.0
RPS8	10296.0
RPS27L	9869.0
RPL39L	9655.0
RPL18	9621.0
EEF1A1	9096.0
EEF1D	8934.0
RPL23A	8852.0
RPLP1	8689.0
EEF1A2	8347.0
RPLP2	8239.0
EEF1G	8025.0
RPL37	7695.0
RPS13	7369.0
RPL36AL	7147.0
RPS20	7077.0
RPL4	6779.0
RPL36	6145.0
RPS3	5505.0
RPL8	5310.0
RPL10A	5072.0
RPL15	4446.0
RPL3	4267.0
RPLP0	3455.0
RPS15A	3120.0
RPL11	2419.0
RPS12	2257.0
RPL27A	1306.0
RPL22	1272.0
RPL5	852.0
RPL31	733.0
RPL35	467.0
RPS15	-220.0
RPL21	-682.0
FAU	-1469.0
EEF1B2	-1647.0
RPL22L1	-1702.0
RPL6	-4235.0

---

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

	777
set	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
setSize	12
pANOVA	0.0183
s.dist	-0.393
p.adjustANOVA	0.174

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRIM4	-6652
RIPK1	-5245
FADD	-4998
CASP10	-3558
CHUK	-2452
TRIM25	-1856
DDX58	-752
RNF135	4528
IFIH1	5240
MAVS	5384
CASP8	7096
IKBKB	7359

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRIM4	-6652
RIPK1	-5245
FADD	-4998
CASP10	-3558
CHUK	-2452
TRIM25	-1856
DDX58	-752
RNF135	4528
IFIH1	5240
MAVS	5384
CASP8	7096
IKBKB	7359

---

Selenocysteine synthesis

Selenocysteine synthesis

	1208
set	Selenocysteine synthesis
setSize	87
pANOVA	1.02e-09
s.dist	0.378
p.adjustANOVA	1.26e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPL35A	17964
RPS27A	17623
RPL34	17570
RPS14	17460
RPL27	17419
RPL18A	17406
RPSA	16750
RPS27	16701
RPS28	16547
RPL32	16401
RPS16	16394
RPL28	16373
RPS10	16101
RPL7	15788
RPS21	15733
RPL29	15716
RPL10L	15577
RPL17	15487
RPS24	15434

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPL35A	17964.0
RPS27A	17623.0
RPL34	17570.0
RPS14	17460.0
RPL27	17419.0
RPL18A	17406.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPL32	16401.0
RPS16	16394.0
RPL28	16373.0
RPS10	16101.0
RPL7	15788.0
RPS21	15733.0
RPL29	15716.0
RPL10L	15577.0
RPL17	15487.0
RPS24	15434.0
RPL23	15404.0
RPS11	15381.0
RPL38	15324.0
RPS26	15184.0
UBA52	15146.0
RPS23	15084.0
RPL24	14927.0
RPS25	14869.0
RPS6	14761.0
RPL9	14519.0
RPS9	14415.0
RPS29	14234.0
RPL26L1	14132.0
RPL30	13945.0
RPL14	13883.0
RPL26	13496.0
RPL7A	13425.0
RPS2	12789.0
RPL12	12744.0
RPL41	12555.0
RPS7	12370.0
RPL37A	11838.0
RPL3L	11730.0
RPS5	11632.0
RPS18	11410.0
RPL13A	11201.5
RPS3A	11123.0
RPL19	10992.0
RPS19	10890.0
RPL13	10808.0
RPS8	10296.0
RPS27L	9869.0
RPL39L	9655.0
RPL18	9621.0
RPL23A	8852.0
RPLP1	8689.0
RPLP2	8239.0
RPL37	7695.0
RPS13	7369.0
RPL36AL	7147.0
RPS20	7077.0
EEFSEC	6881.0
RPL4	6779.0
RPL36	6145.0
RPS3	5505.0
RPL8	5310.0
RPL10A	5072.0
RPL15	4446.0
SEPHS2	4404.0
RPL3	4267.0
SECISBP2	4184.0
RPLP0	3455.0
SEPSECS	3124.0
RPS15A	3120.0
RPL11	2419.0
RPS12	2257.0
RPL27A	1306.0
RPL22	1272.0
PSTK	1189.0
RPL5	852.0
RPL31	733.0
RPL35	467.0
RPS15	-220.0
RPL21	-682.0
FAU	-1469.0
RPL22L1	-1702.0
RPL6	-4235.0

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	829
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	89
pANOVA	1.18e-09
s.dist	0.373
p.adjustANOVA	1.26e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPL35A	17964
RPS27A	17623
RPL34	17570
RPS14	17460
RPL27	17419
RPL18A	17406
RPSA	16750
RPS27	16701
RPS28	16547
RPL32	16401
RPS16	16394
RPL28	16373
RPS10	16101
RPL7	15788
RPS21	15733
RPL29	15716
RPL10L	15577
RPL17	15487
RPS24	15434

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPL35A	17964.0
RPS27A	17623.0
RPL34	17570.0
RPS14	17460.0
RPL27	17419.0
RPL18A	17406.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPL32	16401.0
RPS16	16394.0
RPL28	16373.0
RPS10	16101.0
RPL7	15788.0
RPS21	15733.0
RPL29	15716.0
RPL10L	15577.0
RPL17	15487.0
RPS24	15434.0
RPL23	15404.0
RPS11	15381.0
RPL38	15324.0
RPS26	15184.0
UBA52	15146.0
RPS23	15084.0
RPL24	14927.0
RPS25	14869.0
RPS6	14761.0
RPL9	14519.0
RPS9	14415.0
RPS29	14234.0
RPL26L1	14132.0
RPL30	13945.0
RPL14	13883.0
RPL26	13496.0
RPL7A	13425.0
EIF4G1	13114.0
RPS2	12789.0
RPL12	12744.0
RPL41	12555.0
RPS7	12370.0
RPL37A	11838.0
RPL3L	11730.0
RPS5	11632.0
RPS18	11410.0
RPL13A	11201.5
RPS3A	11123.0
RPL19	10992.0
RPS19	10890.0
RPL13	10808.0
RPS8	10296.0
RPS27L	9869.0
RPL39L	9655.0
RPL18	9621.0
UPF1	9418.0
RPL23A	8852.0
RPLP1	8689.0
RPLP2	8239.0
RPL37	7695.0
RPS13	7369.0
RPL36AL	7147.0
RPS20	7077.0
RPL4	6779.0
RPL36	6145.0
RPS3	5505.0
RPL8	5310.0
RPL10A	5072.0
ETF1	4788.0
RPL15	4446.0
RPL3	4267.0
GSPT1	4234.0
RPLP0	3455.0
RPS15A	3120.0
RPL11	2419.0
RPS12	2257.0
PABPC1	1667.0
NCBP1	1531.0
RPL27A	1306.0
RPL22	1272.0
RPL5	852.0
RPL31	733.0
RPL35	467.0
RPS15	-220.0
RPL21	-682.0
NCBP2	-975.0
FAU	-1469.0
RPL22L1	-1702.0
RPL6	-4235.0

---

NRIF signals cell death from the nucleus

NRIF signals cell death from the nucleus

	793
set	NRIF signals cell death from the nucleus
setSize	16
pANOVA	0.01
s.dist	0.372
p.adjustANOVA	0.123

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	17623
APH1B	17290
UBC	17042
UBA52	15146
UBB	15063
APH1A	14609
PSEN2	13707
TRAF6	9524
NGF	8768
PSEN1	8681
PSENEN	8537
NGFR	7653
ITGB3BP	5286
SQSTM1	5152
NCSTN	2113
MAPK8	-3330

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	17623
APH1B	17290
UBC	17042
UBA52	15146
UBB	15063
APH1A	14609
PSEN2	13707
TRAF6	9524
NGF	8768
PSEN1	8681
PSENEN	8537
NGFR	7653
ITGB3BP	5286
SQSTM1	5152
NCSTN	2113
MAPK8	-3330

---

TICAM1,TRAF6-dependent induction of TAK1 complex

TICAM1,TRAF6-dependent induction of TAK1 complex

	1364
set	TICAM1,TRAF6-dependent induction of TAK1 complex
setSize	10
pANOVA	0.0444
s.dist	0.367
p.adjustANOVA	0.291

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
MAP3K7	16345
UBA52	15146
UBB	15063
TLR3	11133
TRAF6	9524
TAB1	2822
TICAM1	812
TAB2	-4298

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
MAP3K7	16345
UBA52	15146
UBB	15063
TLR3	11133
TRAF6	9524
TAB1	2822
TICAM1	812
TAB2	-4298

---

Intrinsic Pathway of Fibrin Clot Formation

Intrinsic Pathway of Fibrin Clot Formation

	646
set	Intrinsic Pathway of Fibrin Clot Formation
setSize	21
pANOVA	0.00381
s.dist	-0.365
p.adjustANOVA	0.0633

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PROS1	-6679
GP5	-5879
SERPINC1	-5768
A2M	-4977
F11	-3879
SERPIND1	-3063
SERPINE2	-2989
GP1BA	-2009
PROC	-1021
KNG1	-830
GP9	213
F12	293
F10	1817
PRCP	2075
VWF	4332
SERPINA5	4505
GP1BB	5527
SERPING1	5568
KLKB1	5924
C1QBP	7179

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PROS1	-6679
GP5	-5879
SERPINC1	-5768
A2M	-4977
F11	-3879
SERPIND1	-3063
SERPINE2	-2989
GP1BA	-2009
PROC	-1021
KNG1	-830
GP9	213
F12	293
F10	1817
PRCP	2075
VWF	4332
SERPINA5	4505
GP1BB	5527
SERPING1	5568
KLKB1	5924
C1QBP	7179
F2	14563

---

Tandem pore domain potassium channels

Tandem pore domain potassium channels

	1390
set	Tandem pore domain potassium channels
setSize	12
pANOVA	0.0288
s.dist	0.365
p.adjustANOVA	0.229

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KCNK16	17421
KCNK18	16819
KCNK6	14501
KCNK7	13732
KCNK17	12557
KCNK10	11671
KCNK4	10547
KCNK3	9192
KCNK9	8381
KCNK1	4007
KCNK13	1366
KCNK2	866

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KCNK16	17421
KCNK18	16819
KCNK6	14501
KCNK7	13732
KCNK17	12557
KCNK10	11671
KCNK4	10547
KCNK3	9192
KCNK9	8381
KCNK1	4007
KCNK13	1366
KCNK2	866

---

Regulation of IFNA/IFNB signaling

Regulation of IFNA/IFNB signaling

	1086
set	Regulation of IFNA/IFNB signaling
setSize	22
pANOVA	0.00331
s.dist	-0.362
p.adjustANOVA	0.0589

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IFNA6	-7454
IFNA16	-7423
IFNA2	-7251
IFNA21	-7180
IFNA14	-7099
IFNB1	-7088
IFNA1	-7038
IFNA5	-5828
PTPN11	-5020
IFNA7	-4450
STAT1	-4154
IFNA8	-2780
JAK1	-1659
STAT2	4463
IFNAR2	5854
TYK2	6414
SOCS3	7430
PTPN1	10443
PTPN6	11736
IFNAR1	13771

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IFNA6	-7454
IFNA16	-7423
IFNA2	-7251
IFNA21	-7180
IFNA14	-7099
IFNB1	-7088
IFNA1	-7038
IFNA5	-5828
PTPN11	-5020
IFNA7	-4450
STAT1	-4154
IFNA8	-2780
JAK1	-1659
STAT2	4463
IFNAR2	5854
TYK2	6414
SOCS3	7430
PTPN1	10443
PTPN6	11736
IFNAR1	13771
USP18	14882
SOCS1	15898

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

	1145
set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	95
pANOVA	1.17e-09
s.dist	0.361
p.adjustANOVA	1.26e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPL35A	17964
RPS27A	17623
RPL34	17570
RPS14	17460
RPL27	17419
RPL18A	17406
RPSA	16750
RPS27	16701
RPS28	16547
RPL32	16401
RPS16	16394
RPL28	16373
RPS10	16101
RPL7	15788
RPS21	15733
RPL29	15716
RPL10L	15577
RPL17	15487
RPS24	15434

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPL35A	17964.0
RPS27A	17623.0
RPL34	17570.0
RPS14	17460.0
RPL27	17419.0
RPL18A	17406.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPL32	16401.0
RPS16	16394.0
RPL28	16373.0
RPS10	16101.0
RPL7	15788.0
RPS21	15733.0
RPL29	15716.0
RPL10L	15577.0
RPL17	15487.0
RPS24	15434.0
RPL23	15404.0
ATF2	15388.0
RPS11	15381.0
RPL38	15324.0
RPS26	15184.0
UBA52	15146.0
RPS23	15084.0
RPL24	14927.0
RPS25	14869.0
RPS6	14761.0
RPL9	14519.0
RPS9	14415.0
RPS29	14234.0
RPL26L1	14132.0
RPL30	13945.0
RPL14	13883.0
RPL26	13496.0
RPL7A	13425.0
DDIT3	13284.0
GCN1	13237.0
RPS2	12789.0
RPL12	12744.0
RPL41	12555.0
RPS7	12370.0
CEBPG	12189.0
RPL37A	11838.0
RPL3L	11730.0
RPS5	11632.0
EIF2AK4	11475.0
RPS18	11410.0
RPL13A	11201.5
RPS3A	11123.0
RPL19	10992.0
RPS19	10890.0
RPL13	10808.0
RPS8	10296.0
RPS27L	9869.0
RPL39L	9655.0
RPL18	9621.0
RPL23A	8852.0
RPLP1	8689.0
RPLP2	8239.0
ASNS	7915.0
RPL37	7695.0
RPS13	7369.0
RPL36AL	7147.0
RPS20	7077.0
RPL4	6779.0
RPL36	6145.0
RPS3	5505.0
RPL8	5310.0
RPL10A	5072.0
ATF4	4664.0
RPL15	4446.0
RPL3	4267.0
RPLP0	3455.0
RPS15A	3120.0
CEBPB	2992.0
RPL11	2419.0
RPS12	2257.0
EIF2S1	1847.0
ATF3	1514.0
RPL27A	1306.0
RPL22	1272.0
RPL5	852.0
RPL31	733.0
TRIB3	530.0
RPL35	467.0
RPS15	-220.0
RPL21	-682.0
EIF2S2	-941.0
FAU	-1469.0
RPL22L1	-1702.0
IMPACT	-3793.0
RPL6	-4235.0

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	449
set	Formation of a pool of free 40S subunits
setSize	94
pANOVA	1.71e-09
s.dist	0.359
p.adjustANOVA	1.65e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPL35A	17964
EIF3G	17865
RPS27A	17623
RPL34	17570
RPS14	17460
RPL27	17419
RPL18A	17406
RPSA	16750
RPS27	16701
RPS28	16547
RPL32	16401
RPS16	16394
RPL28	16373
RPS10	16101
RPL7	15788
RPS21	15733
RPL29	15716
RPL10L	15577
RPL17	15487

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPL35A	17964.0
EIF3G	17865.0
RPS27A	17623.0
RPL34	17570.0
RPS14	17460.0
RPL27	17419.0
RPL18A	17406.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPL32	16401.0
RPS16	16394.0
RPL28	16373.0
RPS10	16101.0
RPL7	15788.0
RPS21	15733.0
RPL29	15716.0
RPL10L	15577.0
RPL17	15487.0
RPS24	15434.0
RPL23	15404.0
RPS11	15381.0
RPL38	15324.0
RPS26	15184.0
UBA52	15146.0
RPS23	15084.0
RPL24	14927.0
RPS25	14869.0
RPS6	14761.0
EIF3D	14542.0
RPL9	14519.0
RPS9	14415.0
RPS29	14234.0
RPL26L1	14132.0
RPL30	13945.0
RPL14	13883.0
RPL26	13496.0
RPL7A	13425.0
EIF3I	12960.0
RPS2	12789.0
RPL12	12744.0
RPL41	12555.0
RPS7	12370.0
RPL37A	11838.0
RPL3L	11730.0
RPS5	11632.0
RPS18	11410.0
RPL13A	11201.5
RPS3A	11123.0
RPL19	10992.0
RPS19	10890.0
RPL13	10808.0
RPS8	10296.0
RPS27L	9869.0
RPL39L	9655.0
RPL18	9621.0
RPL23A	8852.0
RPLP1	8689.0
RPLP2	8239.0
RPL37	7695.0
EIF3B	7424.0
RPS13	7369.0
RPL36AL	7147.0
RPS20	7077.0
RPL4	6779.0
EIF3J	6721.0
EIF3E	6441.0
RPL36	6145.0
RPS3	5505.0
RPL8	5310.0
RPL10A	5072.0
EIF3K	4535.0
RPL15	4446.0
RPL3	4267.0
EIF3L	3545.0
RPLP0	3455.0
EIF3F	3217.0
RPS15A	3120.0
RPL11	2419.0
RPS12	2257.0
RPL27A	1306.0
RPL22	1272.0
RPL5	852.0
RPL31	733.0
RPL35	467.0
RPS15	-220.0
RPL21	-682.0
FAU	-1469.0
EIF3H	-1690.0
RPL22L1	-1702.0
EIF3A	-3383.0
EIF3M	-3931.0
RPL6	-4235.0

---

Signaling by cytosolic FGFR1 fusion mutants

Signaling by cytosolic FGFR1 fusion mutants

	1310
set	Signaling by cytosolic FGFR1 fusion mutants
setSize	17
pANOVA	0.0108
s.dist	-0.357
p.adjustANOVA	0.131

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ZMYM2	-5435
STAT1	-4154
TRIM24	-3939
STAT5A	-3538
STAT5B	-2708
GAB2	-2592
CNTRL	-974
CUX1	-850
STAT3	454
LRRFIP1	987
FGFR1OP2	1031
GRB2	3241
CPSF6	3376
PIK3CA	5249
BCR	7309
MYO18A	7475
PIK3R1	8833

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ZMYM2	-5435
STAT1	-4154
TRIM24	-3939
STAT5A	-3538
STAT5B	-2708
GAB2	-2592
CNTRL	-974
CUX1	-850
STAT3	454
LRRFIP1	987
FGFR1OP2	1031
GRB2	3241
CPSF6	3376
PIK3CA	5249
BCR	7309
MYO18A	7475
PIK3R1	8833

---

Sensory perception of sweet, bitter, and umami (glutamate) taste

Sensory perception of sweet, bitter, and umami (glutamate) taste

	1215
set	Sensory perception of sweet, bitter, and umami (glutamate) taste
setSize	41
pANOVA	7.68e-05
s.dist	-0.357
p.adjustANOVA	0.00242

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAS2R46	-7339
TAS2R10	-7306
TAS2R4	-7233
TAS2R14	-6983
TAS2R50	-6656
TAS2R8	-6601
TAS2R43	-6600
TAS2R39	-6469
TAS2R13	-6411
TAS2R3	-6389
TAS2R31	-5781
TAS2R30	-5769
TAS2R5	-5318
GNAT3	-4554
TAS2R7	-4436
TAS2R16	-4099
GNG13	-4054
TAS2R1	-3267
TAS2R38	-2766
SCN3A	-1615

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAS2R46	-7339
TAS2R10	-7306
TAS2R4	-7233
TAS2R14	-6983
TAS2R50	-6656
TAS2R8	-6601
TAS2R43	-6600
TAS2R39	-6469
TAS2R13	-6411
TAS2R3	-6389
TAS2R31	-5781
TAS2R30	-5769
TAS2R5	-5318
GNAT3	-4554
TAS2R7	-4436
TAS2R16	-4099
GNG13	-4054
TAS2R1	-3267
TAS2R38	-2766
SCN3A	-1615
TAS1R2	-767
TAS2R20	-749
GRM1	2427
GNB1	2634
SCN9A	2744
CALHM1	2907
PLCB2	3318
SCN2B	3609
CALHM3	4068
TAS1R3	5729
TAS2R40	7295
SCN2A	7350
GNB3	7987
SCN4B	8832
GRM4	8862
TAS2R41	9019
ITPR3	10927
TRPM5	11997
TRPM4	13148
SCN1B	14870
TAS1R1	16838

---

Pausing and recovery of Tat-mediated HIV elongation

Pausing and recovery of Tat-mediated HIV elongation

	901
set	Pausing and recovery of Tat-mediated HIV elongation
setSize	27
pANOVA	0.00137
s.dist	0.356
p.adjustANOVA	0.0307

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2K	18005
SUPT5H	17546
POLR2J	17537
NELFB	17306
CDK9	16364
TCEA1	16072
POLR2E	15351
SUPT4H1	15226
POLR2D	15138
SSRP1	14710
CCNT1	13227
POLR2H	11868
POLR2L	11588
POLR2F	11205
POLR2I	10571
ELL	9284
NELFA	7707
POLR2A	7258
POLR2B	5067
NELFE	5043

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2K	18005
SUPT5H	17546
POLR2J	17537
NELFB	17306
CDK9	16364
TCEA1	16072
POLR2E	15351
SUPT4H1	15226
POLR2D	15138
SSRP1	14710
CCNT1	13227
POLR2H	11868
POLR2L	11588
POLR2F	11205
POLR2I	10571
ELL	9284
NELFA	7707
POLR2A	7258
POLR2B	5067
NELFE	5043
POLR2C	4753
POLR2G	3709
SUPT16H	2892
CTDP1	2574
NELFCD	1651
GTF2F1	269
GTF2F2	-2649

---

Tat-mediated HIV elongation arrest and recovery

Tat-mediated HIV elongation arrest and recovery

	1391
set	Tat-mediated HIV elongation arrest and recovery
setSize	27
pANOVA	0.00137
s.dist	0.356
p.adjustANOVA	0.0307

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2K	18005
SUPT5H	17546
POLR2J	17537
NELFB	17306
CDK9	16364
TCEA1	16072
POLR2E	15351
SUPT4H1	15226
POLR2D	15138
SSRP1	14710
CCNT1	13227
POLR2H	11868
POLR2L	11588
POLR2F	11205
POLR2I	10571
ELL	9284
NELFA	7707
POLR2A	7258
POLR2B	5067
NELFE	5043

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2K	18005
SUPT5H	17546
POLR2J	17537
NELFB	17306
CDK9	16364
TCEA1	16072
POLR2E	15351
SUPT4H1	15226
POLR2D	15138
SSRP1	14710
CCNT1	13227
POLR2H	11868
POLR2L	11588
POLR2F	11205
POLR2I	10571
ELL	9284
NELFA	7707
POLR2A	7258
POLR2B	5067
NELFE	5043
POLR2C	4753
POLR2G	3709
SUPT16H	2892
CTDP1	2574
NELFCD	1651
GTF2F1	269
GTF2F2	-2649

---

Caspase activation via Death Receptors in the presence of ligand

Caspase activation via Death Receptors in the presence of ligand

	172
set	Caspase activation via Death Receptors in the presence of ligand
setSize	16
pANOVA	0.0142
s.dist	-0.354
p.adjustANOVA	0.153

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LY96	-6864
CD14	-5904
FASLG	-5653
RIPK1	-5245
FADD	-4998
TLR4	-1575
TICAM2	-1504
TNFRSF10A	-1218
TNFRSF10B	716
TICAM1	812
TNFSF10	1565
CFLAR	4199
CASP8	7096
FAS	7842
TRAF2	8353
TRADD	15909

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LY96	-6864
CD14	-5904
FASLG	-5653
RIPK1	-5245
FADD	-4998
TLR4	-1575
TICAM2	-1504
TNFRSF10A	-1218
TNFRSF10B	716
TICAM1	812
TNFSF10	1565
CFLAR	4199
CASP8	7096
FAS	7842
TRAF2	8353
TRADD	15909

---

p75NTR recruits signalling complexes

p75NTR recruits signalling complexes

	1536
set	p75NTR recruits signalling complexes
setSize	12
pANOVA	0.0356
s.dist	0.35
p.adjustANOVA	0.254

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
UBA52	15146
UBB	15063
MYD88	10379
TRAF6	9524
NGF	8768
NGFR	7653
IKBKB	7359
PRKCI	5995
SQSTM1	5152
RIPK2	-840

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	17623
UBC	17042
UBA52	15146
UBB	15063
MYD88	10379
TRAF6	9524
NGF	8768
NGFR	7653
IKBKB	7359
PRKCI	5995
SQSTM1	5152
RIPK2	-840

---

HIV elongation arrest and recovery

HIV elongation arrest and recovery

	550
set	HIV elongation arrest and recovery
setSize	29
pANOVA	0.00116
s.dist	0.348
p.adjustANOVA	0.027

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2K	18005
SUPT5H	17546
POLR2J	17537
NELFB	17306
CDK9	16364
TCEA1	16072
POLR2E	15351
SUPT4H1	15226
POLR2D	15138
SSRP1	14710
CCNT1	13227
POLR2H	11868
CCNK	11598
POLR2L	11588
POLR2F	11205
POLR2I	10571
ELL	9284
NELFA	7707
POLR2A	7258
CCNT2	5581

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2K	18005
SUPT5H	17546
POLR2J	17537
NELFB	17306
CDK9	16364
TCEA1	16072
POLR2E	15351
SUPT4H1	15226
POLR2D	15138
SSRP1	14710
CCNT1	13227
POLR2H	11868
CCNK	11598
POLR2L	11588
POLR2F	11205
POLR2I	10571
ELL	9284
NELFA	7707
POLR2A	7258
CCNT2	5581
POLR2B	5067
NELFE	5043
POLR2C	4753
POLR2G	3709
SUPT16H	2892
CTDP1	2574
NELFCD	1651
GTF2F1	269
GTF2F2	-2649

---

Pausing and recovery of HIV elongation

Pausing and recovery of HIV elongation

	900
set	Pausing and recovery of HIV elongation
setSize	29
pANOVA	0.00116
s.dist	0.348
p.adjustANOVA	0.027

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2K	18005
SUPT5H	17546
POLR2J	17537
NELFB	17306
CDK9	16364
TCEA1	16072
POLR2E	15351
SUPT4H1	15226
POLR2D	15138
SSRP1	14710
CCNT1	13227
POLR2H	11868
CCNK	11598
POLR2L	11588
POLR2F	11205
POLR2I	10571
ELL	9284
NELFA	7707
POLR2A	7258
CCNT2	5581

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2K	18005
SUPT5H	17546
POLR2J	17537
NELFB	17306
CDK9	16364
TCEA1	16072
POLR2E	15351
SUPT4H1	15226
POLR2D	15138
SSRP1	14710
CCNT1	13227
POLR2H	11868
CCNK	11598
POLR2L	11588
POLR2F	11205
POLR2I	10571
ELL	9284
NELFA	7707
POLR2A	7258
CCNT2	5581
POLR2B	5067
NELFE	5043
POLR2C	4753
POLR2G	3709
SUPT16H	2892
CTDP1	2574
NELFCD	1651
GTF2F1	269
GTF2F2	-2649

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

	455
set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	46
pANOVA	4.47e-05
s.dist	0.348
p.adjustANOVA	0.0015

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
EIF3G	17865
RPS27A	17623
RPS14	17460
RPSA	16750
RPS27	16701
RPS28	16547
RPS16	16394
RPS10	16101
RPS21	15733
RPS24	15434
RPS11	15381
RPS26	15184
RPS23	15084
RPS25	14869
RPS6	14761
EIF3D	14542
RPS9	14415
RPS29	14234
EIF3I	12960

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998
EIF3G	17865
RPS27A	17623
RPS14	17460
RPSA	16750
RPS27	16701
RPS28	16547
RPS16	16394
RPS10	16101
RPS21	15733
RPS24	15434
RPS11	15381
RPS26	15184
RPS23	15084
RPS25	14869
RPS6	14761
EIF3D	14542
RPS9	14415
RPS29	14234
EIF3I	12960
RPS2	12789
RPS7	12370
RPS5	11632
RPS18	11410
RPS3A	11123
RPS19	10890
RPS8	10296
RPS27L	9869
EIF3B	7424
RPS13	7369
RPS20	7077
EIF3J	6721
EIF3E	6441
RPS3	5505
EIF3K	4535
EIF3L	3545
EIF3F	3217
RPS15A	3120
RPS12	2257
EIF2S1	1847
RPS15	-220
EIF2S2	-941
FAU	-1469
EIF3H	-1690
EIF3A	-3383
EIF3M	-3931

---

NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus

	787
set	NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize	11
pANOVA	0.0467
s.dist	0.346
p.adjustANOVA	0.292

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APH1B	17290
YWHAZ	15102
APH1A	14609
DLL4	13911
PSEN2	13707
PSEN1	8681
PSENEN	8537
JAG1	7042
NOTCH4	4531
ADAM10	2882
NCSTN	2113

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APH1B	17290
YWHAZ	15102
APH1A	14609
DLL4	13911
PSEN2	13707
PSEN1	8681
PSENEN	8537
JAG1	7042
NOTCH4	4531
ADAM10	2882
NCSTN	2113

---

Interleukin-15 signaling

Interleukin-15 signaling

	628
set	Interleukin-15 signaling
setSize	13
pANOVA	0.0308
s.dist	-0.346
p.adjustANOVA	0.237

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAT5A	-3538
SOS2	-3122
STAT5B	-2708
GAB2	-2592
SOS1	-2269
JAK1	-1659
IL15	-1584
STAT3	454
GRB2	3241
IL15RA	3385
IL2RB	6203
SHC1	7057
JAK3	9478

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAT5A	-3538
SOS2	-3122
STAT5B	-2708
GAB2	-2592
SOS1	-2269
JAK1	-1659
IL15	-1584
STAT3	454
GRB2	3241
IL15RA	3385
IL2RB	6203
SHC1	7057
JAK3	9478

---

SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery

	1169
set	SARS-CoV-2 modulates host translation machinery
setSize	46
pANOVA	6.31e-05
s.dist	0.341
p.adjustANOVA	0.00203

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPS27A	17623
RPS14	17460
GEMIN4	17233
GEMIN6	17215
RPSA	16750
RPS27	16701
RPS28	16547
RPS16	16394
RPS10	16101
RPS21	15733
RPS24	15434
RPS11	15381
RPS26	15184
RPS23	15084
RPS25	14869
RPS6	14761
RPS9	14415
RPS29	14234
RPS2	12789

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPS27A	17623.0
RPS14	17460.0
GEMIN4	17233.0
GEMIN6	17215.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPS16	16394.0
RPS10	16101.0
RPS21	15733.0
RPS24	15434.0
RPS11	15381.0
RPS26	15184.0
RPS23	15084.0
RPS25	14869.0
RPS6	14761.0
RPS9	14415.0
RPS29	14234.0
RPS2	12789.0
RPS7	12370.0
SNRPE	11674.0
RPS5	11632.0
RPS18	11410.0
RPS3A	11123.0
RPS19	10890.0
RPS8	10296.0
SNRPD2	9917.0
RPS27L	9869.0
SNRPB	7901.0
SNRPD1	7756.0
RPS13	7369.0
RPS20	7077.0
SNRPF	6044.0
RPS3	5505.0
SNRPG	4432.0
RPS15A	3120.0
SNRPD3	2542.0
RPS12	2257.0
GEMIN5	544.0
RPS15	-220.0
FAU	-1469.0
DDX20	-2110.0
GEMIN2	-4722.0
GEMIN7	-5985.0
SMN1	-7354.5

---

Selenoamino acid metabolism

Selenoamino acid metabolism

	1207
set	Selenoamino acid metabolism
setSize	103
pANOVA	3.25e-09
s.dist	0.337
p.adjustANOVA	2.65e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPL35A	17964
RPS27A	17623
RPL34	17570
RPS14	17460
RPL27	17419
RPL18A	17406
RPSA	16750
RPS27	16701
RPS28	16547
RPL32	16401
RPS16	16394
RPL28	16373
RPS10	16101
RPL7	15788
RPS21	15733
RPL29	15716
RPL10L	15577
RPL17	15487
RPS24	15434

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPL35A	17964.0
RPS27A	17623.0
RPL34	17570.0
RPS14	17460.0
RPL27	17419.0
RPL18A	17406.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPL32	16401.0
RPS16	16394.0
RPL28	16373.0
RPS10	16101.0
RPL7	15788.0
RPS21	15733.0
RPL29	15716.0
RPL10L	15577.0
RPL17	15487.0
RPS24	15434.0
RPL23	15404.0
RPS11	15381.0
RPL38	15324.0
RPS26	15184.0
UBA52	15146.0
RPS23	15084.0
GSR	15015.0
RPL24	14927.0
RPS25	14869.0
RPS6	14761.0
GNMT	14576.0
RPL9	14519.0
RPS9	14415.0
RPS29	14234.0
RPL26L1	14132.0
RPL30	13945.0
RPL14	13883.0
RPL26	13496.0
RPL7A	13425.0
MAT1A	13366.0
RPS2	12789.0
RPL12	12744.0
RPL41	12555.0
RPS7	12370.0
RPL37A	11838.0
RPL3L	11730.0
RPS5	11632.0
RPS18	11410.0
RPL13A	11201.5
RPS3A	11123.0
RPL19	10992.0
RPS19	10890.0
RPL13	10808.0
RPS8	10296.0
TXNRD1	10171.0
AHCY	10121.0
CTH	10038.0
PAPSS2	9945.0
RPS27L	9869.0
RPL39L	9655.0
RPL18	9621.0
RPL23A	8852.0
RPLP1	8689.0
RPLP2	8239.0
NNMT	7725.0
RPL37	7695.0
RPS13	7369.0
RPL36AL	7147.0
RPS20	7077.0
PAPSS1	7051.0
EEFSEC	6881.0
RPL4	6779.0
CBS	6598.0
RPL36	6145.0
RPS3	5505.0
RPL8	5310.0
RPL10A	5072.0
RPL15	4446.0
SEPHS2	4404.0
INMT	4311.0
RPL3	4267.0
SECISBP2	4184.0
RPLP0	3455.0
HNMT	3216.0
SEPSECS	3124.0
RPS15A	3120.0
RPL11	2419.0
RPS12	2257.0
AIMP1	1642.0
RPL27A	1306.0
RPL22	1272.0
PSTK	1189.0
RPL5	852.0
RPL31	733.0
RPL35	467.0
RPS15	-220.0
RPL21	-682.0
AIMP2	-702.0
FAU	-1469.0
EEF1E1	-1527.0
RPL22L1	-1702.0
SCLY	-2228.0
RPL6	-4235.0

---

Attenuation phase

Attenuation phase

	105
set	Attenuation phase
setSize	25
pANOVA	0.00351
s.dist	0.337
p.adjustANOVA	0.0597

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HSPA1B	17619
DNAJB1	17407
RLN1	16258
SERPINH1	15956
HSPA6	15776
HSPA1A	15149
UBB	15063
HSBP1	14924
HSPA2	14666
HSP90AA1	14304
PTGES3	13287
CRYBA4	13066
FKBP4	12309
HSF1	10287
HSPA8	10210
HSPA1L	7148
GML	5432
DEDD2	4935
HSPH1	4283
MRPL18	3284

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HSPA1B	17619
DNAJB1	17407
RLN1	16258
SERPINH1	15956
HSPA6	15776
HSPA1A	15149
UBB	15063
HSBP1	14924
HSPA2	14666
HSP90AA1	14304
PTGES3	13287
CRYBA4	13066
FKBP4	12309
HSF1	10287
HSPA8	10210
HSPA1L	7148
GML	5432
DEDD2	4935
HSPH1	4283
MRPL18	3284
TNFRSF21	2226
CREBBP	955
HSP90AB1	555
EP300	381
DNAJB6	-2121

---

Chylomicron assembly

Chylomicron assembly

	205
set	Chylomicron assembly
setSize	10
pANOVA	0.0652
s.dist	0.337
p.adjustANOVA	0.341

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APOA2	17615
APOC3	15561
APOC2	14895
APOA1	12062
APOA4	10060
APOE	9123
MTTP	9001
SAR1B	7480
APOB	3390
P4HB	-1886

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APOA2	17615
APOC3	15561
APOC2	14895
APOA1	12062
APOA4	10060
APOE	9123
MTTP	9001
SAR1B	7480
APOB	3390
P4HB	-1886

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	663
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	103
pANOVA	4.02e-09
s.dist	0.335
p.adjustANOVA	2.96e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPL35A	17964
EIF3G	17865
RPS27A	17623
RPL34	17570
RPS14	17460
RPL27	17419
RPL18A	17406
RPSA	16750
RPS27	16701
RPS28	16547
RPL32	16401
RPS16	16394
RPL28	16373
RPS10	16101
RPL7	15788
RPS21	15733
RPL29	15716
RPL10L	15577
RPL17	15487

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPL35A	17964.0
EIF3G	17865.0
RPS27A	17623.0
RPL34	17570.0
RPS14	17460.0
RPL27	17419.0
RPL18A	17406.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPL32	16401.0
RPS16	16394.0
RPL28	16373.0
RPS10	16101.0
RPL7	15788.0
RPS21	15733.0
RPL29	15716.0
RPL10L	15577.0
RPL17	15487.0
RPS24	15434.0
RPL23	15404.0
RPS11	15381.0
RPL38	15324.0
RPS26	15184.0
UBA52	15146.0
RPS23	15084.0
RPL24	14927.0
RPS25	14869.0
RPS6	14761.0
EIF3D	14542.0
RPL9	14519.0
RPS9	14415.0
EIF4A2	14275.0
RPS29	14234.0
RPL26L1	14132.0
RPL30	13945.0
RPL14	13883.0
RPL26	13496.0
RPL7A	13425.0
EIF4G1	13114.0
EIF4E	13005.0
EIF3I	12960.0
RPS2	12789.0
RPL12	12744.0
RPL41	12555.0
RPS7	12370.0
RPL37A	11838.0
RPL3L	11730.0
RPS5	11632.0
RPS18	11410.0
RPL13A	11201.5
RPS3A	11123.0
RPL19	10992.0
RPS19	10890.0
RPL13	10808.0
RPS8	10296.0
RPS27L	9869.0
RPL39L	9655.0
RPL18	9621.0
RPL23A	8852.0
RPLP1	8689.0
RPLP2	8239.0
RPL37	7695.0
EIF3B	7424.0
RPS13	7369.0
RPL36AL	7147.0
RPS20	7077.0
RPL4	6779.0
EIF4B	6741.0
EIF3J	6721.0
EIF3E	6441.0
RPL36	6145.0
EIF4H	6065.0
RPS3	5505.0
RPL8	5310.0
RPL10A	5072.0
EIF3K	4535.0
RPL15	4446.0
RPL3	4267.0
EIF3L	3545.0
RPLP0	3455.0
EIF3F	3217.0
RPS15A	3120.0
EIF4A1	2463.0
RPL11	2419.0
RPS12	2257.0
EIF2S1	1847.0
PABPC1	1667.0
RPL27A	1306.0
RPL22	1272.0
RPL5	852.0
RPL31	733.0
RPL35	467.0
RPS15	-220.0
RPL21	-682.0
EIF2S2	-941.0
FAU	-1469.0
EIF3H	-1690.0
RPL22L1	-1702.0
EIF3A	-3383.0
EIF3M	-3931.0
RPL6	-4235.0

---

Platelet Adhesion to exposed collagen

Platelet Adhesion to exposed collagen

	929
set	Platelet Adhesion to exposed collagen
setSize	13
pANOVA	0.0366
s.dist	-0.335
p.adjustANOVA	0.257

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GP5	-5879
GP6	-5595
FCER1G	-5377
LYN	-4273
FYN	-3230
GP1BA	-2009
GP9	213
ITGA10	2193
ITGA1	3465
VWF	4332
GP1BB	5527
ITGA2	10509
ITGB1	14335

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GP5	-5879
GP6	-5595
FCER1G	-5377
LYN	-4273
FYN	-3230
GP1BA	-2009
GP9	213
ITGA10	2193
ITGA1	3465
VWF	4332
GP1BB	5527
ITGA2	10509
ITGB1	14335

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	493
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	104
pANOVA	3.93e-09
s.dist	0.334
p.adjustANOVA	2.96e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
RPL35A	17964
EIF3G	17865
RPS27A	17623
RPL34	17570
RPS14	17460
RPL27	17419
RPL18A	17406
RPSA	16750
RPS27	16701
RPS28	16547
RPL32	16401
RPS16	16394
RPL28	16373
RPS10	16101
RPL7	15788
RPS21	15733
RPL29	15716
RPL10L	15577
RPL17	15487

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998.0
RPL35A	17964.0
EIF3G	17865.0
RPS27A	17623.0
RPL34	17570.0
RPS14	17460.0
RPL27	17419.0
RPL18A	17406.0
RPSA	16750.0
RPS27	16701.0
RPS28	16547.0
RPL32	16401.0
RPS16	16394.0
RPL28	16373.0
RPS10	16101.0
RPL7	15788.0
RPS21	15733.0
RPL29	15716.0
RPL10L	15577.0
RPL17	15487.0
RPS24	15434.0
RPL23	15404.0
RPS11	15381.0
RPL38	15324.0
RPS26	15184.0
UBA52	15146.0
RPS23	15084.0
RPL24	14927.0
RPS25	14869.0
RPS6	14761.0
EIF3D	14542.0
RPL9	14519.0
RPS9	14415.0
EIF4A2	14275.0
RPS29	14234.0
RPL26L1	14132.0
RPL30	13945.0
RPL14	13883.0
RPL26	13496.0
RPL7A	13425.0
EIF4G1	13114.0
EIF4E	13005.0
EIF3I	12960.0
RPS2	12789.0
RPL12	12744.0
RPL41	12555.0
RPS7	12370.0
RPL37A	11838.0
RPL3L	11730.0
RPS5	11632.0
RPS18	11410.0
RPL13A	11201.5
RPS3A	11123.0
RPL19	10992.0
RPS19	10890.0
RPL13	10808.0
RPS8	10296.0
RPS27L	9869.0
RPL39L	9655.0
RPL18	9621.0
RPL23A	8852.0
RPLP1	8689.0
RPLP2	8239.0
RPL37	7695.0
EIF3B	7424.0
RPS13	7369.0
RPL36AL	7147.0
RPS20	7077.0
RPL4	6779.0
EIF4B	6741.0
EIF3J	6721.0
EIF5B	6601.0
EIF3E	6441.0
RPL36	6145.0
EIF4H	6065.0
RPS3	5505.0
RPL8	5310.0
RPL10A	5072.0
EIF3K	4535.0
RPL15	4446.0
RPL3	4267.0
EIF3L	3545.0
RPLP0	3455.0
EIF3F	3217.0
RPS15A	3120.0
EIF5	2884.0
EIF4A1	2463.0
RPL11	2419.0
RPS12	2257.0
EIF2S1	1847.0
RPL27A	1306.0
RPL22	1272.0
RPL5	852.0
RPL31	733.0
RPL35	467.0
RPS15	-220.0
RPL21	-682.0
EIF2S2	-941.0
FAU	-1469.0
EIF3H	-1690.0
RPL22L1	-1702.0
EIF3A	-3383.0
EIF3M	-3931.0
RPL6	-4235.0

---

Biosynthesis of DHA-derived SPMs

Biosynthesis of DHA-derived SPMs

	125
set	Biosynthesis of DHA-derived SPMs
setSize	17
pANOVA	0.0173
s.dist	0.334
p.adjustANOVA	0.168

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PTGS2	17868
CYP2E1	17310
ALOX12	17279
CYP1A2	15894
CYP2D6	14012
GPX4	12680
CYP3A4	11967
LTC4S	10798
GSTM4	10453
ALOX5	9755
HPGD	9371
LTA4H	8036
ALOX15	7416
CYP1A1	7088
EPHX2	5655
CYP2C8	-5402
CYP2C9	-5476

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PTGS2	17868
CYP2E1	17310
ALOX12	17279
CYP1A2	15894
CYP2D6	14012
GPX4	12680
CYP3A4	11967
LTC4S	10798
GSTM4	10453
ALOX5	9755
HPGD	9371
LTA4H	8036
ALOX15	7416
CYP1A1	7088
EPHX2	5655
CYP2C8	-5402
CYP2C9	-5476

---

Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition

	1156
set	Ribosomal scanning and start codon recognition
setSize	53
pANOVA	2.82e-05
s.dist	0.332
p.adjustANOVA	0.00112

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
EIF3G	17865
RPS27A	17623
RPS14	17460
RPSA	16750
RPS27	16701
RPS28	16547
RPS16	16394
RPS10	16101
RPS21	15733
RPS24	15434
RPS11	15381
RPS26	15184
RPS23	15084
RPS25	14869
RPS6	14761
EIF3D	14542
RPS9	14415
EIF4A2	14275
RPS29	14234

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998
EIF3G	17865
RPS27A	17623
RPS14	17460
RPSA	16750
RPS27	16701
RPS28	16547
RPS16	16394
RPS10	16101
RPS21	15733
RPS24	15434
RPS11	15381
RPS26	15184
RPS23	15084
RPS25	14869
RPS6	14761
EIF3D	14542
RPS9	14415
EIF4A2	14275
RPS29	14234
EIF4G1	13114
EIF4E	13005
EIF3I	12960
RPS2	12789
RPS7	12370
RPS5	11632
RPS18	11410
RPS3A	11123
RPS19	10890
RPS8	10296
RPS27L	9869
EIF3B	7424
RPS13	7369
RPS20	7077
EIF4B	6741
EIF3J	6721
EIF3E	6441
EIF4H	6065
RPS3	5505
EIF3K	4535
EIF3L	3545
EIF3F	3217
RPS15A	3120
EIF5	2884
EIF4A1	2463
RPS12	2257
EIF2S1	1847
RPS15	-220
EIF2S2	-941
FAU	-1469
EIF3H	-1690
EIF3A	-3383
EIF3M	-3931

---

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

	54
set	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize	54
pANOVA	2.39e-05
s.dist	0.332
p.adjustANOVA	0.000997

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
EIF3G	17865
RPS27A	17623
RPS14	17460
RPSA	16750
RPS27	16701
RPS28	16547
RPS16	16394
RPS10	16101
RPS21	15733
RPS24	15434
RPS11	15381
RPS26	15184
RPS23	15084
RPS25	14869
RPS6	14761
EIF3D	14542
RPS9	14415
EIF4A2	14275
RPS29	14234

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998
EIF3G	17865
RPS27A	17623
RPS14	17460
RPSA	16750
RPS27	16701
RPS28	16547
RPS16	16394
RPS10	16101
RPS21	15733
RPS24	15434
RPS11	15381
RPS26	15184
RPS23	15084
RPS25	14869
RPS6	14761
EIF3D	14542
RPS9	14415
EIF4A2	14275
RPS29	14234
EIF4G1	13114
EIF4E	13005
EIF3I	12960
RPS2	12789
RPS7	12370
RPS5	11632
RPS18	11410
RPS3A	11123
RPS19	10890
EIF4EBP1	10805
RPS8	10296
RPS27L	9869
EIF3B	7424
RPS13	7369
RPS20	7077
EIF4B	6741
EIF3J	6721
EIF3E	6441
EIF4H	6065
RPS3	5505
EIF3K	4535
EIF3L	3545
EIF3F	3217
RPS15A	3120
EIF4A1	2463
RPS12	2257
EIF2S1	1847
PABPC1	1667
RPS15	-220
EIF2S2	-941
FAU	-1469
EIF3H	-1690
EIF3A	-3383
EIF3M	-3931

---

Translation initiation complex formation

Translation initiation complex formation

	1446
set	Translation initiation complex formation
setSize	53
pANOVA	3.12e-05
s.dist	0.331
p.adjustANOVA	0.00118

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS17	17998
EIF3G	17865
RPS27A	17623
RPS14	17460
RPSA	16750
RPS27	16701
RPS28	16547
RPS16	16394
RPS10	16101
RPS21	15733
RPS24	15434
RPS11	15381
RPS26	15184
RPS23	15084
RPS25	14869
RPS6	14761
EIF3D	14542
RPS9	14415
EIF4A2	14275
RPS29	14234

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS17	17998
EIF3G	17865
RPS27A	17623
RPS14	17460
RPSA	16750
RPS27	16701
RPS28	16547
RPS16	16394
RPS10	16101
RPS21	15733
RPS24	15434
RPS11	15381
RPS26	15184
RPS23	15084
RPS25	14869
RPS6	14761
EIF3D	14542
RPS9	14415
EIF4A2	14275
RPS29	14234
EIF4G1	13114
EIF4E	13005
EIF3I	12960
RPS2	12789
RPS7	12370
RPS5	11632
RPS18	11410
RPS3A	11123
RPS19	10890
RPS8	10296
RPS27L	9869
EIF3B	7424
RPS13	7369
RPS20	7077
EIF4B	6741
EIF3J	6721
EIF3E	6441
EIF4H	6065
RPS3	5505
EIF3K	4535
EIF3L	3545
EIF3F	3217
RPS15A	3120
EIF4A1	2463
RPS12	2257
EIF2S1	1847
PABPC1	1667
RPS15	-220
EIF2S2	-941
FAU	-1469
EIF3H	-1690
EIF3A	-3383
EIF3M	-3931

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    parallel  stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.2.1                                    
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.4.4                                      
##  [4] reshape2_1.4.4                                     
##  [5] beeswarm_0.4.0                                     
##  [6] gplots_3.1.3                                       
##  [7] gtools_3.9.4                                       
##  [8] tibble_3.2.1                                       
##  [9] dplyr_1.1.3                                        
## [10] echarts4r_0.4.5                                    
## [11] eulerr_7.0.0                                       
## [12] kableExtra_1.3.4                                   
## [13] data.table_1.14.8                                  
## [14] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [15] minfi_1.46.0                                       
## [16] bumphunter_1.42.0                                  
## [17] locfit_1.5-9.8                                     
## [18] iterators_1.0.14                                   
## [19] foreach_1.5.2                                      
## [20] Biostrings_2.68.1                                  
## [21] XVector_0.40.0                                     
## [22] SummarizedExperiment_1.30.2                        
## [23] Biobase_2.60.0                                     
## [24] MatrixGenerics_1.12.3                              
## [25] matrixStats_1.1.0                                  
## [26] GenomicRanges_1.52.1                               
## [27] GenomeInfoDb_1.36.4                                
## [28] IRanges_2.34.1                                     
## [29] S4Vectors_0.38.2                                   
## [30] BiocGenerics_0.46.0                                
## [31] mitch_1.12.0                                       
## [32] limma_3.56.2                                       
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.3.1             later_1.3.1              
##   [3] BiocIO_1.10.0             bitops_1.0-7             
##   [5] filelock_1.0.2            preprocessCore_1.61.0    
##   [7] XML_3.99-0.15             lifecycle_1.0.3          
##   [9] lattice_0.21-8            MASS_7.3-60              
##  [11] base64_2.0.1              scrime_1.3.5             
##  [13] magrittr_2.0.3            sass_0.4.7               
##  [15] rmarkdown_2.24            jquerylib_0.1.4          
##  [17] yaml_2.3.7                httpuv_1.6.11            
##  [19] doRNG_1.8.6               askpass_1.2.0            
##  [21] DBI_1.1.3                 RColorBrewer_1.1-3       
##  [23] abind_1.4-5               zlibbioc_1.46.0          
##  [25] rvest_1.0.3               quadprog_1.5-8           
##  [27] purrr_1.0.2               RCurl_1.98-1.13          
##  [29] rappdirs_0.3.3            GenomeInfoDbData_1.2.10  
##  [31] genefilter_1.82.1         annotate_1.78.0          
##  [33] svglite_2.1.2             DelayedMatrixStats_1.22.6
##  [35] codetools_0.2-19          DelayedArray_0.26.7      
##  [37] xml2_1.3.5                tidyselect_1.2.0         
##  [39] beanplot_1.3.1            BiocFileCache_2.11.1     
##  [41] illuminaio_0.42.0         webshot_0.5.5            
##  [43] GenomicAlignments_1.36.0  jsonlite_1.8.7           
##  [45] multtest_2.56.0           ellipsis_0.3.2           
##  [47] survival_3.5-7            systemfonts_1.0.4        
##  [49] tools_4.3.1               progress_1.2.2           
##  [51] Rcpp_1.0.11               glue_1.6.2               
##  [53] gridExtra_2.3             xfun_0.40                
##  [55] HDF5Array_1.28.1          withr_2.5.0              
##  [57] fastmap_1.1.1             rhdf5filters_1.12.1      
##  [59] fansi_1.0.4               openssl_2.1.0            
##  [61] caTools_1.18.2            digest_0.6.33            
##  [63] R6_2.5.1                  mime_0.12                
##  [65] colorspace_2.1-0          biomaRt_2.56.1           
##  [67] RSQLite_2.3.3             tidyr_1.3.0              
##  [69] utf8_1.2.3                generics_0.1.3           
##  [71] rtracklayer_1.60.1        prettyunits_1.1.1        
##  [73] httr_1.4.7                htmlwidgets_1.6.2        
##  [75] S4Arrays_1.0.6            pkgconfig_2.0.3          
##  [77] gtable_0.3.4              blob_1.2.4               
##  [79] siggenes_1.74.0           htmltools_0.5.6          
##  [81] scales_1.2.1              png_0.1-8                
##  [83] knitr_1.43                rstudioapi_0.15.0        
##  [85] tzdb_0.4.0                rjson_0.2.21             
##  [87] nlme_3.1-163              curl_5.0.2               
##  [89] cachem_1.0.8              rhdf5_2.44.0             
##  [91] stringr_1.5.0             KernSmooth_2.23-22       
##  [93] AnnotationDbi_1.62.2      restfulr_0.0.15          
##  [95] GEOquery_2.68.0           pillar_1.9.0             
##  [97] grid_4.3.1                reshape_0.8.9            
##  [99] vctrs_0.6.3               promises_1.2.1           
## [101] dbplyr_2.4.0              xtable_1.8-4             
## [103] evaluate_0.21             readr_2.1.4              
## [105] GenomicFeatures_1.52.2    cli_3.6.1                
## [107] compiler_4.3.1            Rsamtools_2.16.0         
## [109] rlang_1.1.1               crayon_1.5.2             
## [111] rngtools_1.5.2            nor1mix_1.3-0            
## [113] mclust_6.0.0              plyr_1.8.9               
## [115] stringi_1.7.12            viridisLite_0.4.2        
## [117] BiocParallel_1.34.2       munsell_0.5.0            
## [119] Matrix_1.6-1              hms_1.1.3                
## [121] sparseMatrixStats_1.12.2  bit64_4.0.5              
## [123] Rhdf5lib_1.22.1           KEGGREST_1.40.1          
## [125] shiny_1.7.5               highr_0.10               
## [127] memoise_2.0.1             bslib_0.5.1              
## [129] bit_4.0.5

END of report