date generated: 2022-10-16

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                   t        fry
## A1BG     -0.0154034 -0.2018398
## A1BG-AS1 -0.3144579 -0.5352894
## A1CF     -0.7399946 -0.2346351
## A2BP1    -0.2994731 -0.2049889
## A2LD1    -0.1480920 -0.3338861
## A2M      -0.4539317 -0.1586713
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genes_in_profile 25716
duplicated_genes_present 0
num_profile_genes_in_sets 10215
num_profile_genes_not_in_sets 15501
profile_pearson_correl 0.6057
profile_spearman_correl 0.83888

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2584
num_genesets_excluded 1038
num_genesets_included 1546

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 276

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.t s.fry p.t p.fry
cGMP effects 15 2.95e-05 6.51e-04 0.801 -0.658 -0.457 1.01e-05 2.19e-03
Nitric oxide stimulates guanylate cyclase 22 5.30e-05 1.05e-03 0.654 -0.532 -0.380 1.54e-05 2.05e-03
Early Phase of HIV Life Cycle 14 6.20e-03 3.85e-02 0.647 0.420 0.492 6.56e-03 1.44e-03
Collagen chain trimerization 42 3.80e-07 1.96e-05 0.645 -0.483 -0.428 6.03e-08 1.62e-06
PINK1-PRKN Mediated Mitophagy 21 1.04e-03 9.74e-03 0.603 0.381 0.467 2.48e-03 2.13e-04
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 10 2.19e-02 9.39e-02 0.603 0.349 0.491 5.59e-02 7.13e-03
APC/C:Cdc20 mediated degradation of Cyclin B 24 8.81e-04 8.79e-03 0.596 0.405 0.436 5.83e-04 2.16e-04
TICAM1-dependent activation of IRF3/IRF7 12 2.02e-02 8.96e-02 0.591 0.366 0.464 2.81e-02 5.39e-03
Interaction between L1 and Ankyrins 28 1.08e-04 1.79e-03 0.583 -0.462 -0.354 2.27e-05 1.17e-03
Class C/3 (Metabotropic glutamate/pheromone receptors) 39 2.15e-07 1.34e-05 0.568 -0.480 -0.304 2.15e-07 1.01e-03
Mitophagy 27 6.70e-04 6.77e-03 0.564 0.372 0.424 8.10e-04 1.37e-04
Interaction With Cumulus Cells And The Zona Pellucida 11 3.38e-02 1.26e-01 0.562 -0.448 -0.340 1.00e-02 5.10e-02
Bicarbonate transporters 10 5.26e-02 1.72e-01 0.561 -0.441 -0.347 1.57e-02 5.73e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.02e-04 1.71e-03 0.553 0.410 0.371 2.08e-05 1.16e-04
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 7.14e-03 4.28e-02 0.550 0.383 0.395 3.02e-03 2.24e-03
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 14 1.80e-02 8.30e-02 0.550 0.337 0.435 2.91e-02 4.87e-03
Phosphorylation of the APC/C 20 6.90e-03 4.21e-02 0.550 0.377 0.400 3.53e-03 1.93e-03
Mitochondrial iron-sulfur cluster biogenesis 12 4.82e-02 1.63e-01 0.549 0.368 0.408 2.75e-02 1.44e-02
Condensation of Prometaphase Chromosomes 11 6.52e-02 1.95e-01 0.547 0.371 0.402 3.33e-02 2.08e-02
Digestion 18 1.00e-03 9.55e-03 0.546 -0.466 -0.285 6.12e-04 3.66e-02
STAT5 activation downstream of FLT3 ITD mutants 10 7.00e-02 2.02e-01 0.544 0.344 0.421 5.92e-02 2.12e-02
Constitutive Signaling by Overexpressed ERBB2 10 9.03e-02 2.37e-01 0.542 0.378 0.389 3.84e-02 3.32e-02
Prednisone ADME 10 9.88e-03 5.42e-02 0.542 -0.480 -0.251 8.58e-03 1.69e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 5.34e-02 1.74e-01 0.536 -0.433 -0.316 1.76e-02 8.34e-02
Androgen biosynthesis 11 7.72e-02 2.15e-01 0.531 -0.388 -0.363 2.58e-02 3.73e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.33e-02 6.72e-02 0.529 0.411 0.332 3.33e-03 1.77e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.33e-02 6.72e-02 0.529 0.411 0.332 3.33e-03 1.77e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 1.11e-02 5.93e-02 0.525 0.367 0.376 4.50e-03 3.61e-03
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 1.99e-02 8.88e-02 0.523 0.347 0.390 1.31e-02 5.32e-03
APC-Cdc20 mediated degradation of Nek2A 26 3.10e-03 2.35e-02 0.518 0.351 0.381 1.93e-03 7.82e-04
Defective C1GALT1C1 causes TNPS 18 1.90e-02 8.60e-02 0.514 -0.380 -0.347 5.29e-03 1.08e-02
Diseases of mitotic cell cycle 37 2.97e-04 3.50e-03 0.509 0.382 0.337 5.88e-05 3.91e-04
Collagen biosynthesis and modifying enzymes 65 5.97e-07 2.80e-05 0.509 -0.383 -0.335 9.17e-08 3.00e-06
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 2.57e-04 3.16e-03 0.506 0.274 0.425 1.37e-02 1.29e-04
Assembly Of The HIV Virion 16 7.37e-03 4.35e-02 0.505 0.273 0.425 5.87e-02 3.21e-03
Adherens junctions interactions 26 8.50e-05 1.49e-03 0.505 -0.439 -0.250 1.05e-04 2.74e-02
TICAM1, RIP1-mediated IKK complex recruitment 18 2.36e-02 9.86e-02 0.505 0.357 0.358 8.72e-03 8.60e-03
Cleavage of the damaged pyrimidine 16 3.33e-02 1.25e-01 0.504 0.338 0.374 1.92e-02 9.57e-03
Depyrimidination 16 3.33e-02 1.25e-01 0.504 0.338 0.374 1.92e-02 9.57e-03
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 16 3.33e-02 1.25e-01 0.504 0.338 0.374 1.92e-02 9.57e-03
Glucocorticoid biosynthesis 10 1.25e-01 2.95e-01 0.501 -0.340 -0.368 6.23e-02 4.41e-02
Respiratory electron transport 90 7.78e-09 8.02e-07 0.501 0.368 0.339 1.51e-09 2.65e-08
Presynaptic depolarization and calcium channel opening 12 6.92e-02 2.02e-01 0.500 -0.385 -0.318 2.08e-02 5.63e-02
Defective GALNT12 causes CRCS1 18 2.57e-02 1.03e-01 0.496 -0.363 -0.338 7.62e-03 1.30e-02
Defective pyroptosis 11 6.15e-02 1.90e-01 0.493 0.287 0.401 9.96e-02 2.13e-02
Sensory perception of taste 47 6.56e-05 1.21e-03 0.493 -0.368 -0.327 1.24e-05 1.02e-04
Defective GALNT3 causes HFTC 18 2.88e-02 1.13e-01 0.492 -0.348 -0.348 1.06e-02 1.07e-02
Senescence-Associated Secretory Phenotype (SASP) 53 2.77e-05 6.20e-04 0.491 0.357 0.338 7.04e-06 2.06e-05
Phase 0 - rapid depolarisation 31 1.54e-03 1.33e-02 0.491 -0.373 -0.319 3.23e-04 2.08e-03
Base-Excision Repair, AP Site Formation 18 2.09e-02 9.14e-02 0.491 0.312 0.378 2.18e-02 5.44e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.t s.fry p.t p.fry
cGMP effects 15 2.95e-05 6.51e-04 0.80100 -0.658000 -4.57e-01 1.01e-05 2.19e-03
Nitric oxide stimulates guanylate cyclase 22 5.30e-05 1.05e-03 0.65400 -0.532000 -3.80e-01 1.54e-05 2.05e-03
Early Phase of HIV Life Cycle 14 6.20e-03 3.85e-02 0.64700 0.420000 4.92e-01 6.56e-03 1.44e-03
Collagen chain trimerization 42 3.80e-07 1.96e-05 0.64500 -0.483000 -4.28e-01 6.03e-08 1.62e-06
PINK1-PRKN Mediated Mitophagy 21 1.04e-03 9.74e-03 0.60300 0.381000 4.67e-01 2.48e-03 2.13e-04
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 10 2.19e-02 9.39e-02 0.60300 0.349000 4.91e-01 5.59e-02 7.13e-03
APC/C:Cdc20 mediated degradation of Cyclin B 24 8.81e-04 8.79e-03 0.59600 0.405000 4.36e-01 5.83e-04 2.16e-04
TICAM1-dependent activation of IRF3/IRF7 12 2.02e-02 8.96e-02 0.59100 0.366000 4.64e-01 2.81e-02 5.39e-03
Interaction between L1 and Ankyrins 28 1.08e-04 1.79e-03 0.58300 -0.462000 -3.54e-01 2.27e-05 1.17e-03
Class C/3 (Metabotropic glutamate/pheromone receptors) 39 2.15e-07 1.34e-05 0.56800 -0.480000 -3.04e-01 2.15e-07 1.01e-03
Mitophagy 27 6.70e-04 6.77e-03 0.56400 0.372000 4.24e-01 8.10e-04 1.37e-04
Interaction With Cumulus Cells And The Zona Pellucida 11 3.38e-02 1.26e-01 0.56200 -0.448000 -3.40e-01 1.00e-02 5.10e-02
Bicarbonate transporters 10 5.26e-02 1.72e-01 0.56100 -0.441000 -3.47e-01 1.57e-02 5.73e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.02e-04 1.71e-03 0.55300 0.410000 3.71e-01 2.08e-05 1.16e-04
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 7.14e-03 4.28e-02 0.55000 0.383000 3.95e-01 3.02e-03 2.24e-03
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 14 1.80e-02 8.30e-02 0.55000 0.337000 4.35e-01 2.91e-02 4.87e-03
Phosphorylation of the APC/C 20 6.90e-03 4.21e-02 0.55000 0.377000 4.00e-01 3.53e-03 1.93e-03
Mitochondrial iron-sulfur cluster biogenesis 12 4.82e-02 1.63e-01 0.54900 0.368000 4.08e-01 2.75e-02 1.44e-02
Condensation of Prometaphase Chromosomes 11 6.52e-02 1.95e-01 0.54700 0.371000 4.02e-01 3.33e-02 2.08e-02
Digestion 18 1.00e-03 9.55e-03 0.54600 -0.466000 -2.85e-01 6.12e-04 3.66e-02
STAT5 activation downstream of FLT3 ITD mutants 10 7.00e-02 2.02e-01 0.54400 0.344000 4.21e-01 5.92e-02 2.12e-02
Constitutive Signaling by Overexpressed ERBB2 10 9.03e-02 2.37e-01 0.54200 0.378000 3.89e-01 3.84e-02 3.32e-02
Prednisone ADME 10 9.88e-03 5.42e-02 0.54200 -0.480000 -2.51e-01 8.58e-03 1.69e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 5.34e-02 1.74e-01 0.53600 -0.433000 -3.16e-01 1.76e-02 8.34e-02
Androgen biosynthesis 11 7.72e-02 2.15e-01 0.53100 -0.388000 -3.63e-01 2.58e-02 3.73e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.33e-02 6.72e-02 0.52900 0.411000 3.32e-01 3.33e-03 1.77e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.33e-02 6.72e-02 0.52900 0.411000 3.32e-01 3.33e-03 1.77e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 1.11e-02 5.93e-02 0.52500 0.367000 3.76e-01 4.50e-03 3.61e-03
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 1.99e-02 8.88e-02 0.52300 0.347000 3.90e-01 1.31e-02 5.32e-03
APC-Cdc20 mediated degradation of Nek2A 26 3.10e-03 2.35e-02 0.51800 0.351000 3.81e-01 1.93e-03 7.82e-04
Defective C1GALT1C1 causes TNPS 18 1.90e-02 8.60e-02 0.51400 -0.380000 -3.47e-01 5.29e-03 1.08e-02
Diseases of mitotic cell cycle 37 2.97e-04 3.50e-03 0.50900 0.382000 3.37e-01 5.88e-05 3.91e-04
Collagen biosynthesis and modifying enzymes 65 5.97e-07 2.80e-05 0.50900 -0.383000 -3.35e-01 9.17e-08 3.00e-06
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 2.57e-04 3.16e-03 0.50600 0.274000 4.25e-01 1.37e-02 1.29e-04
Assembly Of The HIV Virion 16 7.37e-03 4.35e-02 0.50500 0.273000 4.25e-01 5.87e-02 3.21e-03
Adherens junctions interactions 26 8.50e-05 1.49e-03 0.50500 -0.439000 -2.50e-01 1.05e-04 2.74e-02
TICAM1, RIP1-mediated IKK complex recruitment 18 2.36e-02 9.86e-02 0.50500 0.357000 3.58e-01 8.72e-03 8.60e-03
Cleavage of the damaged pyrimidine 16 3.33e-02 1.25e-01 0.50400 0.338000 3.74e-01 1.92e-02 9.57e-03
Depyrimidination 16 3.33e-02 1.25e-01 0.50400 0.338000 3.74e-01 1.92e-02 9.57e-03
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 16 3.33e-02 1.25e-01 0.50400 0.338000 3.74e-01 1.92e-02 9.57e-03
Glucocorticoid biosynthesis 10 1.25e-01 2.95e-01 0.50100 -0.340000 -3.68e-01 6.23e-02 4.41e-02
Respiratory electron transport 90 7.78e-09 8.02e-07 0.50100 0.368000 3.39e-01 1.51e-09 2.65e-08
Presynaptic depolarization and calcium channel opening 12 6.92e-02 2.02e-01 0.50000 -0.385000 -3.18e-01 2.08e-02 5.63e-02
Defective GALNT12 causes CRCS1 18 2.57e-02 1.03e-01 0.49600 -0.363000 -3.38e-01 7.62e-03 1.30e-02
Defective pyroptosis 11 6.15e-02 1.90e-01 0.49300 0.287000 4.01e-01 9.96e-02 2.13e-02
Sensory perception of taste 47 6.56e-05 1.21e-03 0.49300 -0.368000 -3.27e-01 1.24e-05 1.02e-04
Defective GALNT3 causes HFTC 18 2.88e-02 1.13e-01 0.49200 -0.348000 -3.48e-01 1.06e-02 1.07e-02
Senescence-Associated Secretory Phenotype (SASP) 53 2.77e-05 6.20e-04 0.49100 0.357000 3.38e-01 7.04e-06 2.06e-05
Phase 0 - rapid depolarisation 31 1.54e-03 1.33e-02 0.49100 -0.373000 -3.19e-01 3.23e-04 2.08e-03
Base-Excision Repair, AP Site Formation 18 2.09e-02 9.14e-02 0.49100 0.312000 3.78e-01 2.18e-02 5.44e-03
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 13 4.25e-02 1.49e-01 0.49000 0.290000 3.95e-01 6.98e-02 1.36e-02
MyD88 deficiency (TLR2/4) 16 4.12e-02 1.46e-01 0.49000 0.331000 3.61e-01 2.17e-02 1.25e-02
Membrane binding and targetting of GAG proteins 14 1.40e-02 7.00e-02 0.48800 0.255000 4.16e-01 9.86e-02 7.00e-03
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 1.40e-02 7.00e-02 0.48800 0.255000 4.16e-01 9.86e-02 7.00e-03
Lysosome Vesicle Biogenesis 33 1.75e-03 1.48e-02 0.48400 0.333000 3.51e-01 9.25e-04 4.76e-04
DCC mediated attractive signaling 14 1.56e-02 7.48e-02 0.48400 -0.412000 -2.54e-01 7.61e-03 1.00e-01
Autodegradation of Cdh1 by Cdh1:APC/C 62 5.86e-06 1.65e-04 0.48300 0.358000 3.24e-01 1.11e-06 1.01e-05
Purine ribonucleoside monophosphate biosynthesis 11 9.69e-02 2.49e-01 0.47900 0.375000 2.97e-01 3.13e-02 8.76e-02
TICAM1,TRAF6-dependent induction of TAK1 complex 10 1.54e-01 3.26e-01 0.47800 0.345000 3.32e-01 5.92e-02 6.93e-02
O-glycosylation of TSR domain-containing proteins 37 5.04e-05 1.01e-03 0.47800 -0.400000 -2.61e-01 2.54e-05 5.93e-03
Induction of Cell-Cell Fusion 12 5.86e-02 1.84e-01 0.47500 -0.387000 -2.76e-01 2.03e-02 9.79e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 95 1.64e-08 1.49e-06 0.47500 0.353000 3.17e-01 2.64e-09 9.00e-08
Scavenging of heme from plasma 12 1.09e-01 2.66e-01 0.47400 -0.326000 -3.45e-01 5.04e-02 3.87e-02
Golgi Cisternae Pericentriolar Stack Reorganization 14 5.77e-02 1.81e-01 0.47300 0.368000 2.98e-01 1.71e-02 5.38e-02
Receptor Mediated Mitophagy 10 1.61e-01 3.36e-01 0.47300 0.334000 3.35e-01 6.73e-02 6.67e-02
Josephin domain DUBs 11 1.02e-01 2.57e-01 0.47200 0.292000 3.70e-01 9.38e-02 3.34e-02
SCF(Skp2)-mediated degradation of p27/p21 58 1.61e-05 3.88e-04 0.47100 0.356000 3.09e-01 2.70e-06 4.73e-05
Defective B3GALTL causes PpS 36 4.20e-05 8.78e-04 0.47100 -0.400000 -2.47e-01 3.20e-05 1.02e-02
Transcriptional regulation of granulopoiesis 31 3.21e-03 2.42e-02 0.46900 0.350000 3.13e-01 7.50e-04 2.55e-03
Inactivation of APC/C via direct inhibition of the APC/C complex 21 2.37e-02 9.86e-02 0.46700 0.327000 3.34e-01 9.41e-03 8.14e-03
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 2.37e-02 9.86e-02 0.46700 0.327000 3.34e-01 9.41e-03 8.14e-03
Spry regulation of FGF signaling 16 3.79e-02 1.38e-01 0.46700 0.367000 2.88e-01 1.09e-02 4.62e-02
Assembly of active LPL and LIPC lipase complexes 17 5.02e-02 1.67e-01 0.46400 -0.325000 -3.32e-01 2.03e-02 1.79e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 16 3.80e-02 1.38e-01 0.46400 0.367000 2.84e-01 1.11e-02 4.90e-02
SARS-CoV-1 activates/modulates innate immune responses 37 1.02e-03 9.62e-03 0.46200 0.299000 3.52e-01 1.62e-03 2.07e-04
RIPK1-mediated regulated necrosis 27 5.05e-03 3.37e-02 0.45900 0.284000 3.60e-01 1.06e-02 1.20e-03
Regulation of necroptotic cell death 27 5.05e-03 3.37e-02 0.45900 0.284000 3.60e-01 1.06e-02 1.20e-03
Sensory perception of sweet, bitter, and umami (glutamate) taste 41 2.51e-04 3.16e-03 0.45700 -0.364000 -2.77e-01 5.55e-05 2.16e-03
Polo-like kinase mediated events 16 6.42e-02 1.94e-01 0.45600 0.312000 3.33e-01 3.09e-02 2.10e-02
Laminin interactions 23 7.65e-03 4.41e-02 0.45400 -0.368000 -2.67e-01 2.25e-03 2.68e-02
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 50 1.85e-04 2.53e-03 0.45400 0.336000 3.06e-01 3.93e-05 1.85e-04
Organic anion transporters 10 1.48e-01 3.19e-01 0.45400 -0.282000 -3.56e-01 1.23e-01 5.16e-02
TNFR1-induced proapoptotic signaling 13 1.07e-01 2.64e-01 0.45100 0.300000 3.37e-01 6.07e-02 3.55e-02
Nephrin family interactions 21 1.69e-02 7.93e-02 0.45000 -0.357000 -2.74e-01 4.60e-03 2.94e-02
Plasma lipoprotein remodeling 32 5.11e-03 3.37e-02 0.45000 -0.314000 -3.21e-01 2.08e-03 1.65e-03
Assembly of the pre-replicative complex 82 1.06e-06 4.22e-05 0.44900 0.332000 3.03e-01 2.05e-07 2.02e-06
IKK complex recruitment mediated by RIP1 22 2.56e-02 1.03e-01 0.44900 0.329000 3.07e-01 7.63e-03 1.28e-02
Aspirin ADME 44 6.67e-04 6.77e-03 0.44600 -0.331000 -3.00e-01 1.48e-04 5.81e-04
Diseases associated with glycosylation precursor biosynthesis 15 8.21e-02 2.24e-01 0.44400 0.295000 3.32e-01 4.83e-02 2.59e-02
RHO GTPases activate KTN1 11 1.73e-01 3.50e-01 0.44200 0.314000 3.11e-01 7.14e-02 7.40e-02
Heme degradation 16 5.69e-02 1.80e-01 0.44000 -0.345000 -2.74e-01 1.70e-02 5.76e-02
Processing and activation of SUMO 10 1.74e-01 3.50e-01 0.43900 0.341000 2.77e-01 6.17e-02 1.30e-01
Passive transport by Aquaporins 13 1.18e-01 2.83e-01 0.43900 -0.289000 -3.30e-01 7.12e-02 3.93e-02
Digestion and absorption 23 1.22e-03 1.10e-02 0.43800 -0.386000 -2.07e-01 1.35e-03 8.51e-02
Telomere C-strand synthesis initiation 11 4.13e-02 1.46e-01 0.43500 0.205000 3.84e-01 2.39e-01 2.75e-02
Regulation of BACH1 activity 15 6.52e-02 1.95e-01 0.43500 0.264000 3.45e-01 7.67e-02 2.06e-02
Nuclear import of Rev protein 32 6.10e-03 3.80e-02 0.43400 0.289000 3.25e-01 4.72e-03 1.47e-03
Signaling by BMP 27 1.58e-02 7.58e-02 0.43400 -0.304000 -3.10e-01 6.24e-03 5.36e-03
Diseases of programmed cell death 43 9.64e-04 9.32e-03 0.43200 0.282000 3.28e-01 1.39e-03 1.96e-04
Regulation of APC/C activators between G1/S and early anaphase 79 5.37e-06 1.57e-04 0.43200 0.315000 2.95e-01 1.24e-06 5.62e-06
Na+/Cl- dependent neurotransmitter transporters 18 4.84e-02 1.63e-01 0.43200 -0.273000 -3.35e-01 4.51e-02 1.39e-02
HDL remodeling 10 1.35e-01 3.06e-01 0.43100 -0.247000 -3.54e-01 1.77e-01 5.27e-02
Chylomicron remodeling 10 2.02e-01 3.87e-01 0.43100 -0.281000 -3.26e-01 1.24e-01 7.41e-02
CDK-mediated phosphorylation and removal of Cdc6 71 1.56e-05 3.83e-04 0.43000 0.321000 2.86e-01 2.83e-06 2.98e-05
Maturation of nucleoprotein 9683610 11 1.73e-01 3.50e-01 0.42900 -0.279000 -3.26e-01 1.08e-01 6.11e-02
MET activates PTK2 signaling 18 9.56e-03 5.32e-02 0.42900 -0.373000 -2.13e-01 6.18e-03 1.17e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 34 2.30e-03 1.84e-02 0.42800 0.259000 3.42e-01 9.03e-03 5.67e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 1.96e-05 4.65e-04 0.42500 0.315000 2.86e-01 3.87e-06 2.68e-05
Pexophagy 11 1.97e-01 3.81e-01 0.42500 0.305000 2.96e-01 7.96e-02 8.93e-02
Erythrocytes take up carbon dioxide and release oxygen 12 1.61e-01 3.36e-01 0.42500 -0.317000 -2.83e-01 5.73e-02 8.99e-02
O2/CO2 exchange in erythrocytes 12 1.61e-01 3.36e-01 0.42500 -0.317000 -2.83e-01 5.73e-02 8.99e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.40e-01 3.12e-01 0.42200 0.264000 3.30e-01 1.13e-01 4.81e-02
Mitochondrial protein import 54 3.98e-04 4.38e-03 0.42100 0.303000 2.92e-01 1.15e-04 2.01e-04
CRMPs in Sema3A signaling 15 1.15e-01 2.77e-01 0.42100 -0.298000 -2.98e-01 4.58e-02 4.60e-02
DNA Replication Pre-Initiation 97 8.00e-07 3.53e-05 0.42000 0.305000 2.88e-01 1.97e-07 8.98e-07
Hh mutants are degraded by ERAD 54 2.48e-04 3.16e-03 0.42000 0.320000 2.72e-01 4.61e-05 5.51e-04
APC/C:Cdc20 mediated degradation of Securin 66 6.31e-05 1.21e-03 0.42000 0.310000 2.83e-01 1.30e-05 7.12e-05
Switching of origins to a post-replicative state 90 1.71e-06 6.46e-05 0.41900 0.313000 2.79e-01 2.94e-07 4.63e-06
Reduction of cytosolic Ca++ levels 11 1.73e-01 3.50e-01 0.41900 -0.264000 -3.26e-01 1.30e-01 6.15e-02
MET activates RAS signaling 11 1.99e-01 3.82e-01 0.41900 0.281000 3.11e-01 1.07e-01 7.43e-02
SCF-beta-TrCP mediated degradation of Emi1 53 4.22e-04 4.55e-03 0.41900 0.311000 2.80e-01 8.99e-05 4.15e-04
APC/C-mediated degradation of cell cycle proteins 86 4.66e-06 1.44e-04 0.41700 0.303000 2.87e-01 1.20e-06 4.02e-06
Regulation of mitotic cell cycle 86 4.66e-06 1.44e-04 0.41700 0.303000 2.87e-01 1.20e-06 4.02e-06
Suppression of phagosomal maturation 13 1.59e-01 3.33e-01 0.41700 0.295000 2.94e-01 6.52e-02 6.65e-02
SARS-CoV-2 modulates autophagy 11 1.82e-01 3.60e-01 0.41600 0.264000 3.21e-01 1.30e-01 6.49e-02
Collagen formation 88 1.65e-06 6.39e-05 0.41400 -0.318000 -2.65e-01 2.47e-07 1.76e-05
Negative regulation of NMDA receptor-mediated neuronal transmission 20 4.75e-02 1.62e-01 0.41200 -0.319000 -2.61e-01 1.36e-02 4.33e-02
NEP/NS2 Interacts with the Cellular Export Machinery 30 1.45e-02 7.18e-02 0.41000 0.274000 3.05e-01 9.25e-03 3.83e-03
Repression of WNT target genes 13 1.40e-01 3.12e-01 0.41000 -0.260000 -3.17e-01 1.05e-01 4.76e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 58 3.14e-04 3.62e-03 0.41000 0.301000 2.78e-01 7.21e-05 2.49e-04
Glucuronidation 25 9.78e-03 5.38e-02 0.41000 -0.338000 -2.31e-01 3.42e-03 4.51e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 3.13e-05 6.81e-04 0.40900 0.300000 2.78e-01 6.88e-06 3.12e-05
Nucleotide biosynthesis 14 1.28e-01 3.00e-01 0.40900 0.313000 2.63e-01 4.27e-02 8.79e-02
Metalloprotease DUBs 19 1.48e-02 7.28e-02 0.40800 0.208000 3.51e-01 1.16e-01 8.15e-03
Receptor-type tyrosine-protein phosphatases 16 5.50e-02 1.78e-01 0.40700 -0.335000 -2.31e-01 2.02e-02 1.09e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 74 3.86e-05 8.17e-04 0.40700 0.300000 2.76e-01 8.21e-06 4.10e-05
Interactions of Rev with host cellular proteins 35 8.83e-03 4.96e-02 0.40700 0.284000 2.91e-01 3.60e-03 2.86e-03
SUMOylation of transcription factors 20 2.62e-02 1.04e-01 0.40600 0.335000 2.30e-01 9.40e-03 7.54e-02
IRAK4 deficiency (TLR2/4) 17 1.01e-01 2.55e-01 0.40600 0.282000 2.93e-01 4.43e-02 3.67e-02
Energy dependent regulation of mTOR by LKB1-AMPK 28 2.35e-02 9.86e-02 0.40500 0.289000 2.84e-01 8.12e-03 9.21e-03
Carnitine metabolism 11 1.92e-01 3.74e-01 0.40500 0.316000 2.54e-01 6.99e-02 1.45e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 1.66e-01 3.43e-01 0.40400 0.229000 3.33e-01 2.11e-01 6.82e-02
NCAM1 interactions 36 6.51e-03 4.02e-02 0.40400 -0.265000 -3.05e-01 5.99e-03 1.53e-03
Vpu mediated degradation of CD4 50 1.01e-03 9.58e-03 0.40400 0.302000 2.68e-01 2.15e-04 1.06e-03
TRAF6-mediated induction of TAK1 complex within TLR4 complex 15 1.38e-01 3.09e-01 0.40200 0.283000 2.85e-01 5.73e-02 5.59e-02
Assembly of collagen fibrils and other multimeric structures 56 4.24e-04 4.55e-03 0.40200 -0.304000 -2.63e-01 8.25e-05 6.73e-04
Interactions of Vpr with host cellular proteins 33 1.07e-02 5.80e-02 0.40000 0.262000 3.02e-01 9.24e-03 2.63e-03
TBC/RABGAPs 42 1.73e-04 2.46e-03 0.40000 0.342000 2.08e-01 1.27e-04 1.97e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 7.75e-05 1.41e-03 0.39900 0.297000 2.66e-01 1.51e-05 1.06e-04
Unwinding of DNA 12 1.44e-01 3.16e-01 0.39800 0.322000 2.35e-01 5.36e-02 1.59e-01
Vpr-mediated nuclear import of PICs 32 1.15e-02 6.09e-02 0.39800 0.255000 3.05e-01 1.25e-02 2.81e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 1.08e-03 9.91e-03 0.39700 0.302000 2.58e-01 2.19e-04 1.59e-03
p53-Independent DNA Damage Response 50 1.08e-03 9.91e-03 0.39700 0.302000 2.58e-01 2.19e-04 1.59e-03
p53-Independent G1/S DNA damage checkpoint 50 1.08e-03 9.91e-03 0.39700 0.302000 2.58e-01 2.19e-04 1.59e-03
Degradation of cysteine and homocysteine 14 1.34e-01 3.05e-01 0.39600 0.248000 3.09e-01 1.08e-01 4.54e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 8.20e-05 1.46e-03 0.39600 0.293000 2.66e-01 1.69e-05 9.23e-05
G1/S-Specific Transcription 28 2.62e-02 1.04e-01 0.39600 0.292000 2.67e-01 7.56e-03 1.43e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 9.21e-02 2.39e-01 0.39500 0.297000 2.60e-01 2.94e-02 5.59e-02
Negative regulation of NOTCH4 signaling 52 1.23e-03 1.10e-02 0.39400 0.290000 2.67e-01 2.93e-04 8.67e-04
Nuclear events mediated by NFE2L2 76 6.42e-05 1.21e-03 0.39400 0.285000 2.72e-01 1.69e-05 4.22e-05
Calnexin/calreticulin cycle 25 2.67e-02 1.05e-01 0.39300 0.243000 3.09e-01 3.55e-02 7.39e-03
Export of Viral Ribonucleoproteins from Nucleus 31 1.81e-02 8.30e-02 0.39300 0.263000 2.92e-01 1.13e-02 4.87e-03
Translesion Synthesis by POLH 19 8.09e-02 2.20e-01 0.39200 0.257000 2.97e-01 5.29e-02 2.51e-02
Processing of Intronless Pre-mRNAs 19 9.05e-02 2.37e-01 0.39200 0.286000 2.68e-01 3.11e-02 4.30e-02
Budding and maturation of HIV virion 28 7.37e-03 4.35e-02 0.39000 0.216000 3.25e-01 4.82e-02 2.87e-03
Sensory processing of sound by inner hair cells of the cochlea 62 4.03e-04 4.38e-03 0.39000 -0.287000 -2.64e-01 9.14e-05 3.26e-04
Regulation of RUNX3 expression and activity 53 9.15e-04 9.01e-03 0.39000 0.297000 2.52e-01 1.84e-04 1.47e-03
Transport of Mature mRNAs Derived from Intronless Transcripts 41 4.29e-03 2.99e-02 0.39000 0.251000 2.98e-01 5.38e-03 9.60e-04
p53-Dependent G1 DNA Damage Response 64 2.42e-04 3.14e-03 0.38900 0.295000 2.54e-01 4.56e-05 4.49e-04
p53-Dependent G1/S DNA damage checkpoint 64 2.42e-04 3.14e-03 0.38900 0.295000 2.54e-01 4.56e-05 4.49e-04
Complex I biogenesis 49 2.35e-03 1.87e-02 0.38800 0.281000 2.68e-01 6.69e-04 1.15e-03
G1/S DNA Damage Checkpoints 66 1.99e-04 2.69e-03 0.38800 0.293000 2.54e-01 3.72e-05 3.55e-04
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 2.00e-01 3.82e-01 0.38800 0.265000 2.83e-01 9.74e-02 7.74e-02
Termination of O-glycan biosynthesis 25 4.62e-02 1.59e-01 0.38700 -0.266000 -2.81e-01 2.14e-02 1.49e-02
Hh mutants abrogate ligand secretion 57 4.02e-04 4.38e-03 0.38600 0.302000 2.41e-01 8.04e-05 1.66e-03
Regulation of signaling by NODAL 10 8.95e-02 2.35e-01 0.38600 -0.176000 -3.44e-01 3.36e-01 5.99e-02
Rev-mediated nuclear export of HIV RNA 33 1.83e-02 8.36e-02 0.38600 0.270000 2.75e-01 7.23e-03 6.21e-03
Transport of Mature mRNA Derived from an Intronless Transcript 40 5.68e-03 3.60e-02 0.38300 0.246000 2.94e-01 7.15e-03 1.30e-03
SUMOylation of immune response proteins 10 1.46e-01 3.16e-01 0.38100 0.327000 1.96e-01 7.30e-02 2.84e-01
Cytochrome c-mediated apoptotic response 12 1.92e-01 3.74e-01 0.38100 -0.233000 -3.01e-01 1.61e-01 7.09e-02
Unblocking of NMDA receptors, glutamate binding and activation 19 7.51e-02 2.11e-01 0.38000 -0.300000 -2.33e-01 2.37e-02 7.82e-02
Lysine catabolism 12 2.18e-01 4.03e-01 0.38000 -0.291000 -2.44e-01 8.09e-02 1.43e-01
Formation of apoptosome 10 2.14e-01 4.00e-01 0.38000 -0.218000 -3.11e-01 2.32e-01 8.87e-02
Regulation of the apoptosome activity 10 2.14e-01 4.00e-01 0.38000 -0.218000 -3.11e-01 2.32e-01 8.87e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.79e-01 4.63e-01 0.37700 0.270000 2.64e-01 1.21e-01 1.30e-01
Regulation of TLR by endogenous ligand 17 9.20e-02 2.39e-01 0.37700 0.226000 3.02e-01 1.07e-01 3.12e-02
Aspartate and asparagine metabolism 11 1.92e-01 3.74e-01 0.37600 -0.307000 -2.17e-01 7.75e-02 2.12e-01
SUMOylation of ubiquitinylation proteins 37 1.39e-02 7.00e-02 0.37600 0.263000 2.69e-01 5.67e-03 4.58e-03
TRAF3-dependent IRF activation pathway 15 1.74e-01 3.51e-01 0.37600 0.257000 2.74e-01 8.54e-02 6.57e-02
PRC2 methylates histones and DNA 13 1.24e-01 2.95e-01 0.37600 0.209000 3.12e-01 1.93e-01 5.12e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 1.13e-03 1.03e-02 0.37300 0.292000 2.33e-01 2.39e-04 3.32e-03
Hormone ligand-binding receptors 13 1.51e-01 3.22e-01 0.37200 -0.303000 -2.16e-01 5.82e-02 1.78e-01
Apoptotic cleavage of cell adhesion proteins 11 1.34e-01 3.05e-01 0.37200 -0.319000 -1.91e-01 6.69e-02 2.73e-01
Ubiquitin-dependent degradation of Cyclin D 50 2.83e-03 2.17e-02 0.37100 0.279000 2.45e-01 6.33e-04 2.72e-03
Stabilization of p53 55 1.83e-03 1.54e-02 0.37100 0.274000 2.50e-01 4.34e-04 1.31e-03
Nuclear events stimulated by ALK signaling in cancer 18 1.03e-01 2.59e-01 0.37100 0.233000 2.89e-01 8.75e-02 3.35e-02
Long-term potentiation 22 6.22e-02 1.91e-01 0.37100 -0.290000 -2.32e-01 1.87e-02 5.97e-02
SARS-CoV-1 modulates host translation machinery 34 7.01e-03 4.23e-02 0.37000 0.303000 2.13e-01 2.23e-03 3.14e-02
SUMOylation of SUMOylation proteins 33 2.45e-02 1.00e-01 0.37000 0.268000 2.55e-01 7.70e-03 1.11e-02
Nuclear Pore Complex (NPC) Disassembly 34 1.50e-02 7.29e-02 0.37000 0.234000 2.87e-01 1.84e-02 3.78e-03
Acyl chain remodelling of PI 16 1.64e-01 3.40e-01 0.36900 -0.271000 -2.51e-01 6.04e-02 8.25e-02
ER Quality Control Compartment (ERQC) 20 8.37e-02 2.26e-01 0.36800 0.231000 2.87e-01 7.37e-02 2.62e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 2.29e-03 1.84e-02 0.36700 0.276000 2.43e-01 5.07e-04 2.25e-03
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 3.77e-03 2.74e-02 0.36700 0.278000 2.40e-01 8.43e-04 4.06e-03
G1/S Transition 126 8.31e-07 3.57e-05 0.36700 0.270000 2.49e-01 1.70e-07 1.39e-06
tRNA processing in the nucleus 55 1.36e-03 1.20e-02 0.36700 0.283000 2.33e-01 2.81e-04 2.80e-03
NGF-stimulated transcription 39 8.68e-03 4.91e-02 0.36600 0.285000 2.31e-01 2.09e-03 1.26e-02
Neurexins and neuroligins 52 1.85e-03 1.55e-02 0.36600 -0.284000 -2.31e-01 3.94e-04 3.88e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs 68 5.63e-04 5.76e-03 0.36500 0.267000 2.49e-01 1.38e-04 3.75e-04
Activation of the phototransduction cascade 11 1.46e-01 3.16e-01 0.36400 -0.313000 -1.87e-01 7.26e-02 2.82e-01
Transport of Ribonucleoproteins into the Host Nucleus 30 3.04e-02 1.18e-01 0.36400 0.234000 2.79e-01 2.67e-02 8.21e-03
Interleukin-6 signaling 11 2.65e-01 4.52e-01 0.36400 -0.283000 -2.28e-01 1.04e-01 1.90e-01
Mitotic G1 phase and G1/S transition 144 1.81e-07 1.27e-05 0.36300 0.263000 2.51e-01 4.96e-08 1.99e-07
Cell-cell junction organization 56 8.99e-05 1.56e-03 0.36300 -0.309000 -1.91e-01 6.35e-05 1.35e-02
Sensory processing of sound 69 4.33e-04 4.60e-03 0.36300 -0.273000 -2.38e-01 8.53e-05 6.21e-04
DNA Replication 125 7.46e-07 3.39e-05 0.36200 0.275000 2.36e-01 1.11e-07 5.04e-06
NS1 Mediated Effects on Host Pathways 39 9.67e-03 5.36e-02 0.36200 0.228000 2.81e-01 1.39e-02 2.36e-03
TRAF6 mediated NF-kB activation 24 7.22e-02 2.06e-01 0.36200 0.268000 2.43e-01 2.28e-02 3.97e-02
Cyclin D associated events in G1 46 6.94e-03 4.21e-02 0.36100 0.266000 2.44e-01 1.81e-03 4.15e-03
G1 Phase 46 6.94e-03 4.21e-02 0.36100 0.266000 2.44e-01 1.81e-03 4.15e-03
Vif-mediated degradation of APOBEC3G 50 3.84e-03 2.77e-02 0.36000 0.272000 2.35e-01 8.64e-04 3.98e-03
tRNA Aminoacylation 24 7.75e-02 2.16e-01 0.36000 0.263000 2.46e-01 2.60e-02 3.72e-02
Diseases associated with N-glycosylation of proteins 19 1.29e-01 3.00e-01 0.36000 0.242000 2.65e-01 6.73e-02 4.51e-02
Cleavage of the damaged purine 11 2.76e-01 4.63e-01 0.35900 0.226000 2.79e-01 1.94e-01 1.09e-01
Depurination 11 2.76e-01 4.63e-01 0.35900 0.226000 2.79e-01 1.94e-01 1.09e-01
Recognition and association of DNA glycosylase with site containing an affected purine 11 2.76e-01 4.63e-01 0.35900 0.226000 2.79e-01 1.94e-01 1.09e-01
Cyclin E associated events during G1/S transition 81 1.15e-04 1.83e-03 0.35800 0.274000 2.31e-01 2.05e-05 3.19e-04
Orc1 removal from chromatin 69 4.82e-04 4.97e-03 0.35800 0.272000 2.33e-01 9.37e-05 8.15e-04
Transport of the SLBP Dependant Mature mRNA 34 2.01e-02 8.95e-02 0.35700 0.226000 2.77e-01 2.24e-02 5.21e-03
Nucleotide salvage 21 6.93e-02 2.02e-01 0.35700 0.213000 2.87e-01 9.07e-02 2.28e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 14 2.34e-01 4.16e-01 0.35700 0.249000 2.55e-01 1.07e-01 9.82e-02
Reactions specific to the complex N-glycan synthesis pathway 10 3.18e-01 5.04e-01 0.35600 -0.276000 -2.24e-01 1.30e-01 2.19e-01
Diseases associated with O-glycosylation of proteins 66 2.33e-04 3.11e-03 0.35400 -0.286000 -2.09e-01 5.95e-05 3.26e-03
Degradation of GLI1 by the proteasome 58 2.61e-03 2.06e-02 0.35400 0.256000 2.44e-01 7.28e-04 1.32e-03
Synthesis of DNA 118 3.17e-06 1.14e-04 0.35300 0.268000 2.30e-01 4.94e-07 1.53e-05
Cyclin A:Cdk2-associated events at S phase entry 83 1.02e-04 1.71e-03 0.35300 0.272000 2.25e-01 1.81e-05 3.98e-04
NIK–>noncanonical NF-kB signaling 57 1.96e-03 1.62e-02 0.35100 0.270000 2.24e-01 4.15e-04 3.42e-03
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 1.51e-01 3.22e-01 0.35100 0.289000 1.98e-01 6.11e-02 1.99e-01
Fertilization 26 6.59e-02 1.95e-01 0.35000 -0.264000 -2.30e-01 1.99e-02 4.21e-02
Regulation of ornithine decarboxylase (ODC) 49 5.45e-03 3.52e-02 0.35000 0.266000 2.27e-01 1.25e-03 6.00e-03
Sodium/Calcium exchangers 11 3.24e-01 5.11e-01 0.35000 -0.260000 -2.34e-01 1.36e-01 1.79e-01
Generation of second messenger molecules 30 4.99e-02 1.67e-01 0.34900 -0.252000 -2.42e-01 1.68e-02 2.20e-02
RUNX3 regulates p14-ARF 10 2.81e-01 4.67e-01 0.34900 0.203000 2.84e-01 2.67e-01 1.20e-01
Signaling by FLT3 ITD and TKD mutants 16 1.61e-01 3.36e-01 0.34800 0.215000 2.74e-01 1.37e-01 5.73e-02
Transport of the SLBP independent Mature mRNA 33 2.61e-02 1.04e-01 0.34800 0.219000 2.71e-01 2.95e-02 7.03e-03
Metabolism of amine-derived hormones 17 9.96e-02 2.53e-01 0.34700 -0.288000 -1.94e-01 3.98e-02 1.66e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 12 9.14e-02 2.38e-01 0.34700 -0.310000 -1.56e-01 6.28e-02 3.50e-01
Defective EXT2 causes exostoses 2 12 9.14e-02 2.38e-01 0.34700 -0.310000 -1.56e-01 6.28e-02 3.50e-01
The citric acid (TCA) cycle and respiratory electron transport 143 2.16e-07 1.34e-05 0.34700 0.268000 2.20e-01 3.08e-08 5.60e-06
Deposition of new CENPA-containing nucleosomes at the centromere 26 6.96e-02 2.02e-01 0.34600 0.227000 2.61e-01 4.52e-02 2.12e-02
Nucleosome assembly 26 6.96e-02 2.02e-01 0.34600 0.227000 2.61e-01 4.52e-02 2.12e-02
KEAP1-NFE2L2 pathway 103 4.42e-05 9.12e-04 0.34600 0.248000 2.41e-01 1.35e-05 2.39e-05
Dectin-1 mediated noncanonical NF-kB signaling 60 1.62e-03 1.39e-02 0.34500 0.267000 2.19e-01 3.42e-04 3.40e-03
Autodegradation of the E3 ubiquitin ligase COP1 50 5.78e-03 3.65e-02 0.34500 0.262000 2.25e-01 1.33e-03 6.00e-03
GLI3 is processed to GLI3R by the proteasome 58 3.48e-03 2.55e-02 0.34300 0.252000 2.33e-01 8.79e-04 2.16e-03
SUMOylation of DNA replication proteins 44 1.46e-02 7.23e-02 0.34300 0.239000 2.46e-01 6.15e-03 4.70e-03
Mitochondrial translation termination 87 1.24e-04 1.94e-03 0.34300 0.263000 2.20e-01 2.23e-05 3.90e-04
ABC transporters in lipid homeostasis 17 7.09e-02 2.04e-01 0.34300 -0.294000 -1.75e-01 3.56e-02 2.10e-01
Assembly of the ORC complex at the origin of replication 10 3.76e-01 5.56e-01 0.34200 0.253000 2.30e-01 1.65e-01 2.08e-01
RNA Polymerase III Transcription Initiation 36 2.99e-02 1.16e-01 0.34200 0.253000 2.29e-01 8.53e-03 1.72e-02
Miscellaneous transport and binding events 21 1.16e-01 2.78e-01 0.34100 -0.219000 -2.62e-01 8.21e-02 3.79e-02
SARS-CoV-1-host interactions 90 1.83e-04 2.53e-03 0.34100 0.249000 2.33e-01 4.40e-05 1.35e-04
Sensory Perception 567 2.56e-26 3.96e-23 0.34000 -0.265000 -2.13e-01 2.43e-27 3.68e-18
FLT3 signaling in disease 28 5.47e-02 1.77e-01 0.33900 0.215000 2.63e-01 4.94e-02 1.60e-02
Cell junction organization 79 2.73e-05 6.20e-04 0.33800 -0.283000 -1.85e-01 1.40e-05 4.40e-03
Degradation of DVL 55 3.95e-03 2.80e-02 0.33800 0.259000 2.16e-01 8.78e-04 5.50e-03
ERKs are inactivated 13 1.30e-01 3.01e-01 0.33700 0.292000 1.69e-01 6.84e-02 2.91e-01
Transcriptional Regulation by E2F6 32 1.49e-02 7.29e-02 0.33600 0.185000 2.81e-01 7.07e-02 5.95e-03
TP53 Regulates Metabolic Genes 83 4.48e-04 4.68e-03 0.33600 0.229000 2.45e-01 3.01e-04 1.10e-04
Mitochondrial translation 93 9.25e-05 1.59e-03 0.33600 0.258000 2.14e-01 1.64e-05 3.50e-04
Glutamate and glutamine metabolism 12 3.29e-01 5.16e-01 0.33600 0.231000 2.44e-01 1.66e-01 1.44e-01
Regulated Necrosis 53 9.38e-04 9.12e-03 0.33500 0.184000 2.81e-01 2.07e-02 4.06e-04
CaMK IV-mediated phosphorylation of CREB 10 2.13e-01 3.99e-01 0.33500 -0.290000 -1.68e-01 1.12e-01 3.57e-01
Transcriptional regulation of testis differentiation 12 3.04e-01 4.91e-01 0.33500 0.257000 2.14e-01 1.23e-01 1.99e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 7.56e-02 2.12e-01 0.33500 0.244000 2.29e-01 2.54e-02 3.58e-02
Intrinsic Pathway of Fibrin Clot Formation 21 8.08e-02 2.20e-01 0.33500 -0.274000 -1.92e-01 2.97e-02 1.28e-01
The NLRP3 inflammasome 16 2.26e-01 4.08e-01 0.33400 0.247000 2.26e-01 8.76e-02 1.18e-01
CLEC7A (Dectin-1) induces NFAT activation 11 1.28e-01 3.00e-01 0.33400 -0.299000 -1.49e-01 8.60e-02 3.92e-01
Olfactory Signaling Pathway 363 3.69e-17 2.85e-14 0.33400 -0.264000 -2.05e-01 5.39e-18 1.81e-11
Sensory processing of sound by outer hair cells of the cochlea 49 8.43e-03 4.79e-02 0.33300 -0.255000 -2.14e-01 2.00e-03 9.40e-03
Phase 2 - plateau phase 14 2.25e-01 4.07e-01 0.33300 -0.264000 -2.02e-01 8.69e-02 1.90e-01
Thyroxine biosynthesis 10 7.99e-02 2.19e-01 0.33300 -0.312000 -1.16e-01 8.77e-02 5.24e-01
Purine salvage 12 3.25e-01 5.11e-01 0.33300 0.221000 2.49e-01 1.86e-01 1.35e-01
Expression and translocation of olfactory receptors 356 7.33e-17 3.78e-14 0.33300 -0.263000 -2.03e-01 1.19e-17 4.33e-11
Diseases associated with the TLR signaling cascade 29 5.04e-02 1.67e-01 0.33200 0.205000 2.61e-01 5.55e-02 1.49e-02
Diseases of Immune System 29 5.04e-02 1.67e-01 0.33200 0.205000 2.61e-01 5.55e-02 1.49e-02
Collagen degradation 39 2.44e-02 1.00e-01 0.33200 -0.252000 -2.16e-01 6.45e-03 1.93e-02
ERBB2 Activates PTK6 Signaling 13 1.35e-01 3.06e-01 0.33200 -0.288000 -1.65e-01 7.23e-02 3.03e-01
mTORC1-mediated signalling 23 1.27e-01 2.98e-01 0.33200 0.236000 2.33e-01 5.02e-02 5.27e-02
G2/M Checkpoints 129 9.52e-06 2.49e-04 0.33100 0.239000 2.29e-01 2.60e-06 6.92e-06
ECM proteoglycans 55 3.52e-03 2.57e-02 0.33100 -0.261000 -2.04e-01 8.26e-04 8.77e-03
MTOR signalling 40 2.83e-02 1.11e-01 0.33000 0.237000 2.31e-01 9.55e-03 1.16e-02
Degradation of GLI2 by the proteasome 58 5.06e-03 3.37e-02 0.33000 0.245000 2.22e-01 1.25e-03 3.49e-03
Peptide chain elongation 84 2.67e-05 6.17e-04 0.33000 0.275000 1.82e-01 1.28e-05 3.89e-03
Defective CFTR causes cystic fibrosis 59 3.36e-03 2.49e-02 0.33000 0.254000 2.11e-01 7.40e-04 5.10e-03
Pyrimidine salvage 10 2.97e-01 4.83e-01 0.33000 0.185000 2.73e-01 3.10e-01 1.35e-01
XBP1(S) activates chaperone genes 47 1.13e-02 6.02e-02 0.32900 0.252000 2.11e-01 2.75e-03 1.25e-02
Mitochondrial translation elongation 87 1.79e-04 2.49e-03 0.32900 0.257000 2.05e-01 3.43e-05 9.52e-04
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 2.46e-01 4.28e-01 0.32800 0.229000 2.34e-01 1.12e-01 1.05e-01
Activation of the TFAP2 (AP-2) family of transcription factors 11 3.28e-01 5.15e-01 0.32800 0.258000 2.02e-01 1.38e-01 2.47e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 2.11e-01 3.97e-01 0.32600 -0.247000 -2.13e-01 7.81e-02 1.28e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 62 3.30e-03 2.45e-02 0.32600 0.248000 2.11e-01 7.26e-04 4.01e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 30 5.26e-02 1.72e-01 0.32500 0.202000 2.55e-01 5.56e-02 1.56e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 30 5.26e-02 1.72e-01 0.32500 0.202000 2.55e-01 5.56e-02 1.56e-02
Mitochondrial translation initiation 87 2.77e-04 3.32e-03 0.32500 0.251000 2.07e-01 5.20e-05 8.43e-04
IRE1alpha activates chaperones 49 1.20e-02 6.30e-02 0.32400 0.245000 2.12e-01 2.98e-03 1.01e-02
Interleukin-35 Signalling 12 3.52e-01 5.35e-01 0.32400 -0.220000 -2.38e-01 1.87e-01 1.54e-01
rRNA modification in the nucleus and cytosol 55 3.28e-03 2.45e-02 0.32300 0.260000 1.93e-01 8.66e-04 1.33e-02
E2F mediated regulation of DNA replication 20 1.83e-01 3.61e-01 0.32300 0.229000 2.28e-01 7.63e-02 7.78e-02
Synthesis of IP3 and IP4 in the cytosol 25 1.06e-01 2.62e-01 0.32300 -0.245000 -2.10e-01 3.41e-02 6.89e-02
Cross-presentation of soluble exogenous antigens (endosomes) 46 7.60e-03 4.41e-02 0.32200 0.260000 1.89e-01 2.23e-03 2.66e-02
Regulation of Apoptosis 51 1.34e-02 6.77e-02 0.32100 0.233000 2.22e-01 4.06e-03 6.13e-03
Cellular response to hypoxia 71 1.49e-03 1.30e-02 0.32100 0.247000 2.04e-01 3.10e-04 2.89e-03
Metabolism of non-coding RNA 50 1.51e-02 7.34e-02 0.32100 0.228000 2.25e-01 5.20e-03 5.86e-03
snRNP Assembly 50 1.51e-02 7.34e-02 0.32100 0.228000 2.25e-01 5.20e-03 5.86e-03
DNA Damage Recognition in GG-NER 36 4.42e-02 1.54e-01 0.32000 0.240000 2.13e-01 1.29e-02 2.73e-02
HIV Life Cycle 139 5.28e-06 1.57e-04 0.32000 0.209000 2.42e-01 2.07e-05 8.47e-07
Dectin-2 family 28 5.02e-02 1.67e-01 0.31900 -0.260000 -1.85e-01 1.72e-02 8.99e-02
Viral mRNA Translation 84 7.96e-05 1.43e-03 0.31900 0.263000 1.80e-01 2.98e-05 4.42e-03
Defective B3GAT3 causes JDSSDHD 17 2.35e-01 4.16e-01 0.31800 -0.237000 -2.12e-01 9.02e-02 1.30e-01
Host Interactions of HIV factors 122 4.66e-05 9.49e-04 0.31700 0.225000 2.24e-01 1.78e-05 1.92e-05
HCMV Late Events 54 7.64e-03 4.41e-02 0.31700 0.200000 2.45e-01 1.10e-02 1.81e-03
Ketone body metabolism 10 2.91e-01 4.78e-01 0.31700 -0.268000 -1.69e-01 1.42e-01 3.55e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 11 4.08e-01 5.88e-01 0.31600 0.223000 2.24e-01 2.00e-01 1.97e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 16 1.54e-01 3.26e-01 0.31600 0.173000 2.65e-01 2.30e-01 6.69e-02
Protein-protein interactions at synapses 78 3.54e-04 4.02e-03 0.31600 -0.256000 -1.85e-01 9.48e-05 4.61e-03
Nuclear Events (kinase and transcription factor activation) 60 5.12e-03 3.37e-02 0.31600 0.242000 2.02e-01 1.16e-03 6.78e-03
Protein ubiquitination 61 4.84e-03 3.30e-02 0.31400 0.200000 2.42e-01 6.76e-03 1.10e-03
Metabolism of porphyrins 27 9.78e-02 2.50e-01 0.31400 -0.240000 -2.03e-01 3.11e-02 6.82e-02
Defective Intrinsic Pathway for Apoptosis 25 1.35e-01 3.06e-01 0.31300 0.218000 2.24e-01 5.88e-02 5.21e-02
Infection with Mycobacterium tuberculosis 25 8.37e-02 2.26e-01 0.31300 0.252000 1.85e-01 2.88e-02 1.10e-01
Activation of RAC1 11 7.64e-02 2.14e-01 0.31300 -0.295000 -1.04e-01 9.03e-02 5.49e-01
Metabolism of steroid hormones 33 7.25e-02 2.07e-01 0.31200 -0.224000 -2.18e-01 2.62e-02 3.03e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 15 1.26e-02 6.48e-02 0.31200 -0.302000 -7.80e-02 4.30e-02 6.01e-01
NCAM signaling for neurite out-growth 57 4.52e-03 3.10e-02 0.31200 -0.188000 -2.49e-01 1.42e-02 1.16e-03
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 12 3.42e-01 5.28e-01 0.31100 0.194000 2.44e-01 2.44e-01 1.44e-01
DNA Damage/Telomere Stress Induced Senescence 28 1.04e-01 2.60e-01 0.31100 0.230000 2.10e-01 3.50e-02 5.47e-02
Ion transport by P-type ATPases 51 1.73e-02 8.07e-02 0.31100 -0.226000 -2.14e-01 5.26e-03 8.07e-03
Growth hormone receptor signaling 24 1.36e-01 3.06e-01 0.31100 -0.204000 -2.35e-01 8.42e-02 4.60e-02
Activation of Matrix Metalloproteinases 31 8.43e-02 2.26e-01 0.31100 -0.227000 -2.12e-01 2.83e-02 4.11e-02
Influenza Infection 148 6.62e-06 1.80e-04 0.30900 0.232000 2.04e-01 1.13e-06 1.74e-05
Adenylate cyclase activating pathway 10 4.61e-01 6.40e-01 0.30800 -0.218000 -2.18e-01 2.32e-01 2.33e-01
SUMOylation of RNA binding proteins 45 3.08e-02 1.19e-01 0.30800 0.220000 2.15e-01 1.06e-02 1.25e-02
Cell recruitment (pro-inflammatory response) 25 1.46e-01 3.16e-01 0.30700 0.216000 2.19e-01 6.21e-02 5.77e-02
Purinergic signaling in leishmaniasis infection 25 1.46e-01 3.16e-01 0.30700 0.216000 2.19e-01 6.21e-02 5.77e-02
Maturation of nucleoprotein 9694631 15 3.06e-01 4.93e-01 0.30700 -0.205000 -2.28e-01 1.70e-01 1.26e-01
Interleukin-27 signaling 11 1.84e-01 3.63e-01 0.30600 -0.139000 -2.73e-01 4.26e-01 1.16e-01
Translocation of ZAP-70 to Immunological synapse 17 1.74e-01 3.50e-01 0.30600 -0.173000 -2.52e-01 2.16e-01 7.17e-02
Eukaryotic Translation Elongation 88 2.53e-05 5.92e-04 0.30600 0.261000 1.59e-01 2.23e-05 9.73e-03
Netrin-1 signaling 49 1.41e-03 1.24e-02 0.30600 -0.267000 -1.50e-01 1.24e-03 6.90e-02
Degradation of the extracellular matrix 108 2.57e-04 3.16e-03 0.30600 -0.222000 -2.11e-01 6.80e-05 1.54e-04
Eukaryotic Translation Termination 87 1.14e-04 1.83e-03 0.30500 0.253000 1.71e-01 4.47e-05 5.82e-03
Extracellular matrix organization 287 6.04e-11 9.34e-09 0.30400 -0.235000 -1.93e-01 7.07e-12 1.87e-08
Metabolism of polyamines 55 1.24e-02 6.42e-02 0.30400 0.231000 1.97e-01 3.06e-03 1.13e-02
ATF6 (ATF6-alpha) activates chaperones 11 2.94e-01 4.80e-01 0.30300 0.163000 2.56e-01 3.49e-01 1.42e-01
Postmitotic nuclear pore complex (NPC) reformation 26 1.28e-01 3.00e-01 0.30300 0.198000 2.30e-01 8.09e-02 4.27e-02
Nuclear Envelope Breakdown 50 1.01e-02 5.48e-02 0.30300 0.180000 2.44e-01 2.81e-02 2.87e-03
Non-integrin membrane-ECM interactions 40 7.07e-03 4.25e-02 0.30300 -0.261000 -1.53e-01 4.29e-03 9.36e-02
Phase 4 - resting membrane potential 19 7.99e-02 2.19e-01 0.30300 -0.147000 -2.64e-01 2.67e-01 4.60e-02
Cellular response to chemical stress 187 9.72e-07 4.00e-05 0.30200 0.213000 2.14e-01 4.69e-07 4.37e-07
Processing of Capped Intronless Pre-mRNA 28 1.09e-01 2.66e-01 0.30200 0.230000 1.96e-01 3.51e-02 7.26e-02
Hedgehog ligand biogenesis 63 4.65e-03 3.18e-02 0.30200 0.238000 1.87e-01 1.11e-03 1.04e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 31 4.11e-02 1.46e-01 0.30200 0.168000 2.51e-01 1.05e-01 1.57e-02
Transport of inorganic cations/anions and amino acids/oligopeptides 101 3.82e-04 4.27e-03 0.30200 -0.228000 -1.98e-01 7.42e-05 5.91e-04
Regulation of innate immune responses to cytosolic DNA 14 3.44e-01 5.30e-01 0.30200 0.202000 2.24e-01 1.91e-01 1.47e-01
Positive epigenetic regulation of rRNA expression 43 2.33e-02 9.84e-02 0.30100 0.239000 1.83e-01 6.59e-03 3.79e-02
Processing of Capped Intron-Containing Pre-mRNA 232 1.25e-08 1.20e-06 0.30100 0.230000 1.95e-01 1.61e-09 3.15e-07
Response of Mtb to phagocytosis 22 1.52e-01 3.23e-01 0.30100 0.238000 1.84e-01 5.37e-02 1.35e-01
Influenza Viral RNA Transcription and Replication 129 3.30e-05 7.08e-04 0.30000 0.231000 1.90e-01 5.59e-06 1.86e-04
Selenocysteine synthesis 87 1.44e-04 2.18e-03 0.30000 0.249000 1.67e-01 5.90e-05 7.17e-03
Keratinization 213 1.32e-07 1.02e-05 0.29900 -0.222000 -2.00e-01 2.26e-08 4.54e-07
Downregulation of ERBB2:ERBB3 signaling 13 2.95e-01 4.81e-01 0.29900 0.173000 2.44e-01 2.80e-01 1.28e-01
Xenobiotics 24 1.31e-01 3.01e-01 0.29900 -0.236000 -1.83e-01 4.52e-02 1.21e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 89 1.42e-04 2.17e-03 0.29800 0.247000 1.67e-01 5.51e-05 6.42e-03
Transcriptional Regulation by VENTX 41 1.89e-02 8.59e-02 0.29800 0.170000 2.45e-01 6.00e-02 6.55e-03
Selective autophagy 59 1.10e-02 5.93e-02 0.29700 0.194000 2.26e-01 1.01e-02 2.69e-03
Interconversion of nucleotide di- and triphosphates 29 6.57e-02 1.95e-01 0.29700 0.243000 1.71e-01 2.35e-02 1.10e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 95 1.49e-04 2.23e-03 0.29700 0.242000 1.71e-01 4.47e-05 3.85e-03
Cell-Cell communication 112 1.52e-05 3.79e-04 0.29700 -0.246000 -1.65e-01 6.69e-06 2.48e-03
TRP channels 24 3.83e-02 1.38e-01 0.29700 -0.262000 -1.39e-01 2.63e-02 2.39e-01
MET promotes cell motility 29 2.90e-02 1.13e-01 0.29600 -0.257000 -1.48e-01 1.67e-02 1.69e-01
RHO GTPases activate PAKs 19 2.05e-01 3.89e-01 0.29600 -0.234000 -1.80e-01 7.74e-02 1.73e-01
Thromboxane signalling through TP receptor 24 8.39e-02 2.26e-01 0.29500 0.161000 2.48e-01 1.73e-01 3.56e-02
HDACs deacetylate histones 29 1.11e-01 2.71e-01 0.29500 0.225000 1.91e-01 3.62e-02 7.45e-02
The phototransduction cascade 32 3.78e-02 1.38e-01 0.29400 -0.247000 -1.60e-01 1.56e-02 1.16e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 1.42e-01 3.13e-01 0.29400 0.146000 2.56e-01 3.14e-01 7.67e-02
E3 ubiquitin ligases ubiquitinate target proteins 43 4.94e-02 1.66e-01 0.29300 0.207000 2.07e-01 1.86e-02 1.87e-02
RHOF GTPase cycle 40 5.56e-02 1.78e-01 0.29200 -0.219000 -1.94e-01 1.66e-02 3.40e-02
Recycling of bile acids and salts 18 3.88e-02 1.40e-01 0.29200 -0.271000 -1.09e-01 4.65e-02 4.22e-01
TNF signaling 45 4.35e-02 1.52e-01 0.29200 0.202000 2.10e-01 1.87e-02 1.46e-02
SUMOylation of chromatin organization proteins 54 2.10e-02 9.14e-02 0.29200 0.195000 2.17e-01 1.34e-02 5.69e-03
Pausing and recovery of Tat-mediated HIV elongation 27 1.07e-01 2.64e-01 0.29200 0.233000 1.76e-01 3.64e-02 1.13e-01
Tat-mediated HIV elongation arrest and recovery 27 1.07e-01 2.64e-01 0.29200 0.233000 1.76e-01 3.64e-02 1.13e-01
PI3K events in ERBB4 signaling 10 3.38e-01 5.24e-01 0.29200 -0.249000 -1.52e-01 1.73e-01 4.04e-01
mRNA Splicing 184 3.90e-07 1.96e-05 0.29200 0.230000 1.79e-01 6.82e-08 2.88e-05
Regulation of TNFR1 signaling 37 7.33e-02 2.07e-01 0.29100 0.215000 1.97e-01 2.35e-02 3.84e-02
Negative regulation of MAPK pathway 41 5.88e-02 1.84e-01 0.29100 0.201000 2.10e-01 2.56e-02 2.02e-02
NoRC negatively regulates rRNA expression 43 4.11e-02 1.46e-01 0.29000 0.223000 1.87e-01 1.15e-02 3.43e-02
Negative regulation of FGFR3 signaling 28 1.73e-02 8.06e-02 0.29000 0.261000 1.27e-01 1.68e-02 2.44e-01
S Phase 157 1.25e-05 3.17e-04 0.29000 0.219000 1.90e-01 2.08e-06 3.86e-05
Late Phase of HIV Life Cycle 126 1.20e-04 1.89e-03 0.29000 0.190000 2.19e-01 2.20e-04 2.22e-05
G0 and Early G1 27 1.57e-01 3.30e-01 0.29000 0.207000 2.03e-01 6.23e-02 6.82e-02
ER-Phagosome pathway 87 2.18e-03 1.77e-02 0.28900 0.216000 1.92e-01 4.91e-04 1.93e-03
Acyl chain remodelling of PC 26 1.70e-01 3.48e-01 0.28900 -0.206000 -2.03e-01 6.94e-02 7.28e-02
Ras activation upon Ca2+ influx through NMDA receptor 19 2.23e-01 4.06e-01 0.28900 -0.228000 -1.77e-01 8.51e-02 1.81e-01
SARS-CoV-1 Infection 134 1.10e-04 1.81e-03 0.28900 0.209000 2.00e-01 3.02e-05 6.51e-05
Trafficking and processing of endosomal TLR 11 4.58e-01 6.38e-01 0.28800 0.190000 2.17e-01 2.75e-01 2.12e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 4.12e-01 5.91e-01 0.28800 0.174000 2.30e-01 3.17e-01 1.87e-01
SHC-mediated cascade:FGFR3 17 3.91e-02 1.41e-01 0.28800 0.270000 9.99e-02 5.37e-02 4.76e-01
Asymmetric localization of PCP proteins 62 7.74e-03 4.43e-02 0.28800 0.227000 1.77e-01 1.95e-03 1.61e-02
Retinoid metabolism and transport 42 5.75e-02 1.81e-01 0.28700 -0.210000 -1.96e-01 1.86e-02 2.77e-02
Initial triggering of complement 21 2.10e-01 3.95e-01 0.28700 -0.222000 -1.81e-01 7.76e-02 1.51e-01
Transport of Mature Transcript to Cytoplasm 76 4.97e-03 3.36e-02 0.28700 0.189000 2.15e-01 4.35e-03 1.16e-03
TNFR2 non-canonical NF-kB pathway 94 1.52e-03 1.31e-02 0.28600 0.214000 1.89e-01 3.31e-04 1.49e-03
Degradation of AXIN 53 2.50e-02 1.02e-01 0.28500 0.215000 1.87e-01 6.69e-03 1.87e-02
Biosynthesis of DHA-derived SPMs 17 3.08e-01 4.96e-01 0.28400 0.186000 2.15e-01 1.83e-01 1.26e-01
Biosynthesis of specialized proresolving mediators (SPMs) 19 2.41e-01 4.23e-01 0.28400 0.177000 2.23e-01 1.82e-01 9.29e-02
Synthesis of PIPs at the late endosome membrane 10 2.73e-01 4.62e-01 0.28400 0.130000 2.53e-01 4.77e-01 1.66e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 3.44e-01 5.30e-01 0.28400 0.208000 1.93e-01 1.50e-01 1.80e-01
A tetrasaccharide linker sequence is required for GAG synthesis 23 2.20e-01 4.05e-01 0.28400 -0.203000 -1.99e-01 9.26e-02 9.82e-02
HIV Infection 216 5.93e-07 2.80e-05 0.28400 0.192000 2.09e-01 1.16e-06 1.15e-07
SARS-CoV-2 modulates host translation machinery 46 1.43e-02 7.11e-02 0.28400 0.236000 1.57e-01 5.53e-03 6.57e-02
Cargo concentration in the ER 32 1.08e-01 2.65e-01 0.28300 0.184000 2.15e-01 7.15e-02 3.49e-02
Transcriptional regulation by small RNAs 46 4.62e-02 1.59e-01 0.28300 0.189000 2.10e-01 2.63e-02 1.38e-02
Branched-chain amino acid catabolism 20 2.25e-01 4.07e-01 0.28300 0.175000 2.22e-01 1.76e-01 8.54e-02
Chylomicron assembly 10 4.69e-01 6.46e-01 0.28200 -0.172000 -2.23e-01 3.45e-01 2.22e-01
Processing of DNA double-strand break ends 61 1.94e-02 8.71e-02 0.28100 0.193000 2.04e-01 9.10e-03 5.87e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 4.91e-01 6.61e-01 0.28100 0.194000 2.03e-01 2.66e-01 2.43e-01
Activation of NF-kappaB in B cells 64 1.66e-02 7.82e-02 0.28000 0.202000 1.94e-01 5.24e-03 7.20e-03
TP53 Regulates Transcription of Cell Death Genes 42 6.43e-02 1.94e-01 0.28000 0.207000 1.88e-01 2.01e-02 3.49e-02
Creation of C4 and C2 activators 14 3.20e-01 5.05e-01 0.28000 -0.227000 -1.63e-01 1.41e-01 2.92e-01
Mitochondrial tRNA aminoacylation 18 2.58e-01 4.44e-01 0.27900 0.222000 1.69e-01 1.03e-01 2.14e-01
Neutrophil degranulation 458 3.07e-13 7.91e-11 0.27900 0.203000 1.90e-01 8.01e-14 2.55e-12
rRNA processing in the nucleus and cytosol 180 1.06e-07 8.61e-06 0.27800 0.232000 1.53e-01 7.29e-08 3.83e-04
rRNA processing 186 5.31e-08 4.56e-06 0.27800 0.233000 1.52e-01 4.21e-08 3.35e-04
Negative epigenetic regulation of rRNA expression 45 4.66e-02 1.60e-01 0.27800 0.213000 1.78e-01 1.33e-02 3.91e-02
Epigenetic regulation of gene expression 83 5.51e-03 3.55e-02 0.27800 0.195000 1.97e-01 2.12e-03 1.87e-03
Regulation of RAS by GAPs 65 1.20e-02 6.30e-02 0.27800 0.213000 1.78e-01 2.94e-03 1.32e-02
Selenoamino acid metabolism 103 2.55e-04 3.16e-03 0.27700 0.226000 1.61e-01 7.38e-05 4.71e-03
Effects of PIP2 hydrolysis 26 1.33e-01 3.04e-01 0.27700 -0.223000 -1.64e-01 4.85e-02 1.48e-01
SRP-dependent cotranslational protein targeting to membrane 105 5.93e-05 1.16e-03 0.27600 0.233000 1.48e-01 3.58e-05 8.63e-03
Cellular Senescence 130 1.65e-04 2.38e-03 0.27600 0.177000 2.12e-01 4.76e-04 3.00e-05
Activation of ATR in response to replication stress 37 8.33e-02 2.25e-01 0.27600 0.212000 1.77e-01 2.58e-02 6.27e-02
Viral Messenger RNA Synthesis 42 6.42e-02 1.94e-01 0.27600 0.180000 2.09e-01 4.35e-02 1.92e-02
mRNA Splicing - Major Pathway 174 4.43e-06 1.43e-04 0.27500 0.217000 1.70e-01 7.86e-07 1.12e-04
Cardiac conduction 123 3.06e-04 3.56e-03 0.27500 -0.210000 -1.78e-01 5.76e-05 6.50e-04
Disorders of Developmental Biology 11 4.83e-01 6.59e-01 0.27500 0.210000 1.78e-01 2.28e-01 3.08e-01
Disorders of Nervous System Development 11 4.83e-01 6.59e-01 0.27500 0.210000 1.78e-01 2.28e-01 3.08e-01
Loss of function of MECP2 in Rett syndrome 11 4.83e-01 6.59e-01 0.27500 0.210000 1.78e-01 2.28e-01 3.08e-01
Pervasive developmental disorders 11 4.83e-01 6.59e-01 0.27500 0.210000 1.78e-01 2.28e-01 3.08e-01
Regulation of PTEN gene transcription 59 2.44e-02 1.00e-01 0.27500 0.203000 1.85e-01 6.87e-03 1.40e-02
Signaling by NOTCH4 79 7.68e-03 4.41e-02 0.27500 0.198000 1.91e-01 2.36e-03 3.37e-03
FGFR1c ligand binding and activation 11 6.57e-02 1.95e-01 0.27500 0.268000 5.91e-02 1.23e-01 7.34e-01
Signaling by activated point mutants of FGFR1 11 6.57e-02 1.95e-01 0.27500 0.268000 5.91e-02 1.23e-01 7.34e-01
Translation 262 1.85e-09 2.20e-07 0.27500 0.222000 1.61e-01 5.44e-10 6.96e-06
Transport of Mature mRNA derived from an Intron-Containing Transcript 67 1.33e-02 6.72e-02 0.27400 0.179000 2.07e-01 1.14e-02 3.30e-03
Stimuli-sensing channels 96 2.43e-04 3.14e-03 0.27200 -0.228000 -1.49e-01 1.12e-04 1.15e-02
Oncogene Induced Senescence 35 1.16e-01 2.79e-01 0.27200 0.184000 2.00e-01 5.98e-02 4.01e-02
Interleukin-20 family signaling 24 8.60e-02 2.29e-01 0.27200 -0.235000 -1.36e-01 4.59e-02 2.49e-01
Cell Cycle Checkpoints 248 3.76e-07 1.96e-05 0.27200 0.192000 1.92e-01 1.86e-07 1.80e-07
FCGR activation 12 4.25e-01 6.02e-01 0.27200 -0.216000 -1.65e-01 1.95e-01 3.23e-01
Transcription of E2F targets under negative control by DREAM complex 19 3.15e-01 5.01e-01 0.27100 0.199000 1.84e-01 1.33e-01 1.66e-01
Regulation of expression of SLITs and ROBOs 159 1.09e-05 2.81e-04 0.27100 0.217000 1.62e-01 2.38e-06 4.06e-04
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.88e-01 3.68e-01 0.27000 0.195000 1.87e-01 7.41e-02 8.72e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 5.37e-01 6.92e-01 0.26900 0.177000 2.03e-01 3.33e-01 2.66e-01
PI3K events in ERBB2 signaling 16 1.45e-01 3.16e-01 0.26900 -0.241000 -1.20e-01 9.54e-02 4.05e-01
Ca-dependent events 35 4.92e-03 3.33e-02 0.26900 -0.249000 -1.01e-01 1.07e-02 2.99e-01
Inactivation, recovery and regulation of the phototransduction cascade 31 5.98e-02 1.86e-01 0.26900 -0.229000 -1.42e-01 2.76e-02 1.72e-01
p38MAPK events 13 4.12e-01 5.91e-01 0.26900 0.212000 1.65e-01 1.86e-01 3.03e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 27 1.21e-02 6.30e-02 0.26700 -0.251000 -9.31e-02 2.41e-02 4.02e-01
Ovarian tumor domain proteases 36 5.19e-02 1.71e-01 0.26700 0.147000 2.23e-01 1.26e-01 2.07e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 108 2.35e-04 3.11e-03 0.26700 0.220000 1.52e-01 7.95e-05 6.36e-03
Nonsense-Mediated Decay (NMD) 108 2.35e-04 3.11e-03 0.26700 0.220000 1.52e-01 7.95e-05 6.36e-03
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 22 2.78e-01 4.63e-01 0.26700 0.192000 1.86e-01 1.19e-01 1.32e-01
Neurodegenerative Diseases 22 2.78e-01 4.63e-01 0.26700 0.192000 1.86e-01 1.19e-01 1.32e-01
Initiation of Nuclear Envelope (NE) Reformation 18 2.38e-01 4.20e-01 0.26700 0.149000 2.21e-01 2.73e-01 1.05e-01
Macroautophagy 111 1.17e-03 1.07e-02 0.26600 0.174000 2.01e-01 1.50e-03 2.43e-04
Bile acid and bile salt metabolism 45 2.90e-04 3.45e-03 0.26600 -0.253000 -8.26e-02 3.30e-03 3.38e-01
Activation of the pre-replicative complex 31 1.66e-01 3.42e-01 0.26600 0.183000 1.93e-01 7.83e-02 6.28e-02
Autophagy 125 3.69e-04 4.17e-03 0.26600 0.168000 2.06e-01 1.16e-03 7.10e-05
Negative regulation of FGFR1 signaling 32 5.16e-03 3.38e-02 0.26600 0.250000 9.07e-02 1.45e-02 3.74e-01
Fanconi Anemia Pathway 36 1.16e-01 2.78e-01 0.26600 0.175000 1.99e-01 6.84e-02 3.84e-02
DNA Damage Bypass 46 5.45e-02 1.77e-01 0.26500 0.167000 2.05e-01 4.96e-02 1.59e-02
Acyl chain remodelling of PS 21 2.28e-01 4.11e-01 0.26500 -0.213000 -1.57e-01 9.10e-02 2.12e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 15 6.40e-02 1.94e-01 0.26400 0.251000 7.88e-02 9.17e-02 5.97e-01
Mitotic Metaphase and Anaphase 222 3.86e-06 1.33e-04 0.26300 0.186000 1.87e-01 1.75e-06 1.63e-06
Activation of HOX genes during differentiation 61 2.23e-02 9.52e-02 0.26300 0.167000 2.04e-01 2.43e-02 5.85e-03
Activation of anterior HOX genes in hindbrain development during early embryogenesis 61 2.23e-02 9.52e-02 0.26300 0.167000 2.04e-01 2.43e-02 5.85e-03
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 35 1.29e-01 3.00e-01 0.26300 0.175000 1.97e-01 7.29e-02 4.40e-02
Antigen processing-Cross presentation 100 2.64e-03 2.07e-02 0.26300 0.199000 1.72e-01 5.76e-04 2.94e-03
RNA polymerase II transcribes snRNA genes 77 1.32e-02 6.72e-02 0.26300 0.185000 1.87e-01 5.00e-03 4.62e-03
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 25 2.43e-01 4.25e-01 0.26200 -0.191000 -1.80e-01 9.83e-02 1.20e-01
Muscle contraction 193 8.92e-06 2.38e-04 0.26200 -0.201000 -1.68e-01 1.42e-06 5.57e-05
Base Excision Repair 45 6.69e-02 1.97e-01 0.26200 0.200000 1.68e-01 2.00e-02 5.08e-02
Major pathway of rRNA processing in the nucleolus and cytosol 171 3.93e-07 1.96e-05 0.26100 0.223000 1.37e-01 5.03e-07 1.98e-03
Defective B4GALT7 causes EDS, progeroid type 17 3.61e-01 5.45e-01 0.26100 -0.200000 -1.68e-01 1.53e-01 2.30e-01
Cytoprotection by HMOX1 58 3.15e-02 1.20e-01 0.26100 0.169000 2.00e-01 2.63e-02 8.54e-03
TP53 Regulates Transcription of Death Receptors and Ligands 12 2.62e-01 4.49e-01 0.26100 0.118000 2.33e-01 4.79e-01 1.62e-01
tRNA processing 98 2.08e-03 1.69e-02 0.26100 0.205000 1.62e-01 4.62e-04 5.59e-03
Protein localization 147 1.57e-04 2.32e-03 0.26000 0.200000 1.66e-01 2.86e-05 5.03e-04
Mitotic Anaphase 221 5.74e-06 1.64e-04 0.26000 0.184000 1.84e-01 2.51e-06 2.42e-06
PD-1 signaling 21 1.72e-01 3.50e-01 0.25900 -0.137000 -2.20e-01 2.78e-01 8.13e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.30e-01 4.14e-01 0.25800 0.185000 1.80e-01 9.56e-02 1.06e-01
FGFR2c ligand binding and activation 12 6.34e-02 1.93e-01 0.25700 0.252000 4.88e-02 1.30e-01 7.70e-01
Metabolism of fat-soluble vitamins 46 8.27e-02 2.24e-01 0.25700 -0.176000 -1.87e-01 3.87e-02 2.83e-02
Formation of a pool of free 40S subunits 94 2.53e-04 3.16e-03 0.25700 0.221000 1.31e-01 2.12e-04 2.86e-02
DSCAM interactions 11 3.35e-01 5.22e-01 0.25700 -0.226000 -1.22e-01 1.95e-01 4.84e-01
Signaling by CSF3 (G-CSF) 28 8.80e-02 2.33e-01 0.25600 0.131000 2.20e-01 2.30e-01 4.41e-02
SHC-mediated cascade:FGFR1 21 8.85e-03 4.96e-02 0.25600 0.251000 4.98e-02 4.65e-02 6.93e-01
Formation of the beta-catenin:TCF transactivating complex 32 1.54e-01 3.26e-01 0.25600 -0.163000 -1.97e-01 1.11e-01 5.32e-02
Acyl chain remodelling of PE 24 2.77e-01 4.63e-01 0.25500 -0.185000 -1.77e-01 1.17e-01 1.34e-01
mRNA 3’-end processing 53 5.99e-02 1.86e-01 0.25500 0.183000 1.78e-01 2.14e-02 2.48e-02
Signaling by EGFR in Cancer 25 1.82e-01 3.61e-01 0.25500 0.148000 2.08e-01 2.00e-01 7.22e-02
ISG15 antiviral mechanism 71 2.37e-02 9.86e-02 0.25400 0.180000 1.80e-01 8.80e-03 8.64e-03
NRAGE signals death through JNK 53 1.93e-02 8.71e-02 0.25400 -0.212000 -1.40e-01 7.56e-03 7.73e-02
GABA synthesis, release, reuptake and degradation 19 3.67e-01 5.50e-01 0.25400 -0.175000 -1.84e-01 1.87e-01 1.66e-01
Caspase activation via Death Receptors in the presence of ligand 16 3.73e-01 5.55e-01 0.25200 0.152000 2.01e-01 2.93e-01 1.65e-01
Regulation of TP53 Activity through Methylation 18 3.95e-01 5.76e-01 0.25100 0.173000 1.82e-01 2.05e-01 1.81e-01
TRAF6 mediated IRF7 activation 26 1.69e-01 3.47e-01 0.25100 0.206000 1.43e-01 6.87e-02 2.08e-01
HCMV Infection 79 4.40e-03 3.05e-02 0.25100 0.142000 2.07e-01 2.89e-02 1.50e-03
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 4.93e-01 6.61e-01 0.25100 0.190000 1.63e-01 2.35e-01 3.09e-01
FCERI mediated NF-kB activation 74 2.30e-02 9.73e-02 0.25000 0.178000 1.76e-01 8.13e-03 8.77e-03
Mitotic Telophase/Cytokinesis 10 3.12e-01 4.99e-01 0.25000 0.104000 2.28e-01 5.70e-01 2.12e-01
Formation of Incision Complex in GG-NER 40 8.24e-02 2.24e-01 0.25000 0.149000 2.01e-01 1.03e-01 2.78e-02
PTEN Regulation 150 4.53e-04 4.70e-03 0.24900 0.183000 1.69e-01 1.04e-04 3.52e-04
Signal amplification 33 6.91e-02 2.02e-01 0.24900 0.129000 2.13e-01 2.01e-01 3.39e-02
Assembly and cell surface presentation of NMDA receptors 23 2.72e-01 4.61e-01 0.24900 -0.194000 -1.56e-01 1.07e-01 1.95e-01
Nuclear Envelope (NE) Reassembly 73 2.53e-02 1.02e-01 0.24900 0.174000 1.78e-01 1.03e-02 8.56e-03
Scavenging by Class A Receptors 19 3.56e-01 5.39e-01 0.24900 -0.190000 -1.60e-01 1.51e-01 2.28e-01
Metabolism of RNA 639 2.43e-16 9.41e-14 0.24800 0.195000 1.54e-01 3.10e-17 2.92e-11
Ca2+ pathway 62 3.87e-03 2.77e-02 0.24800 -0.217000 -1.20e-01 3.13e-03 1.01e-01
Regulation of PTEN stability and activity 66 3.18e-02 1.21e-01 0.24800 0.186000 1.63e-01 8.77e-03 2.19e-02
Synthesis of PA 35 1.25e-01 2.95e-01 0.24800 -0.197000 -1.50e-01 4.36e-02 1.25e-01
Binding and Uptake of Ligands by Scavenger Receptors 41 1.15e-01 2.78e-01 0.24800 -0.188000 -1.62e-01 3.77e-02 7.34e-02
IL-6-type cytokine receptor ligand interactions 17 4.19e-01 5.97e-01 0.24700 -0.184000 -1.65e-01 1.90e-01 2.40e-01
RNA Polymerase III Abortive And Retractive Initiation 41 1.24e-01 2.95e-01 0.24700 0.183000 1.66e-01 4.26e-02 6.66e-02
RNA Polymerase III Transcription 41 1.24e-01 2.95e-01 0.24700 0.183000 1.66e-01 4.26e-02 6.66e-02
Antiviral mechanism by IFN-stimulated genes 78 2.09e-02 9.14e-02 0.24700 0.177000 1.72e-01 6.93e-03 8.61e-03
COPII-mediated vesicle transport 66 3.49e-02 1.30e-01 0.24600 0.165000 1.83e-01 2.05e-02 1.00e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 1.50e-01 3.20e-01 0.24600 0.168000 1.80e-01 7.29e-02 5.48e-02
Eicosanoids 12 5.50e-01 7.01e-01 0.24600 -0.168000 -1.79e-01 3.12e-01 2.82e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 38 1.36e-01 3.06e-01 0.24600 0.187000 1.60e-01 4.60e-02 8.86e-02
HIV Transcription Elongation 38 1.36e-01 3.06e-01 0.24600 0.187000 1.60e-01 4.60e-02 8.86e-02
Tat-mediated elongation of the HIV-1 transcript 38 1.36e-01 3.06e-01 0.24600 0.187000 1.60e-01 4.60e-02 8.86e-02
Mitotic Prophase 78 1.21e-02 6.30e-02 0.24500 0.151000 1.93e-01 2.11e-02 3.12e-03
RAB geranylgeranylation 57 2.82e-03 2.17e-02 0.24500 0.221000 1.08e-01 3.97e-03 1.60e-01
Insulin processing 26 7.31e-02 2.07e-01 0.24500 -0.219000 -1.09e-01 5.27e-02 3.35e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 104 3.25e-04 3.72e-03 0.24400 0.209000 1.27e-01 2.30e-04 2.57e-02
Detoxification of Reactive Oxygen Species 35 1.66e-01 3.43e-01 0.24400 0.185000 1.60e-01 5.84e-02 1.02e-01
Gap junction assembly 18 3.36e-01 5.23e-01 0.24400 -0.197000 -1.44e-01 1.48e-01 2.90e-01
G2/M DNA damage checkpoint 58 5.67e-02 1.80e-01 0.24400 0.165000 1.80e-01 2.99e-02 1.77e-02
Hedgehog ‘on’ state 83 1.74e-02 8.07e-02 0.24400 0.177000 1.68e-01 5.20e-03 8.27e-03
Response of EIF2AK1 (HRI) to heme deficiency 14 4.69e-01 6.46e-01 0.24400 0.190000 1.53e-01 2.19e-01 3.21e-01
CASP8 activity is inhibited 11 4.07e-01 5.87e-01 0.24200 0.121000 2.10e-01 4.88e-01 2.28e-01
Dimerization of procaspase-8 11 4.07e-01 5.87e-01 0.24200 0.121000 2.10e-01 4.88e-01 2.28e-01
Regulation by c-FLIP 11 4.07e-01 5.87e-01 0.24200 0.121000 2.10e-01 4.88e-01 2.28e-01
NRIF signals cell death from the nucleus 16 2.86e-01 4.72e-01 0.24200 0.208000 1.24e-01 1.49e-01 3.92e-01
Alpha-protein kinase 1 signaling pathway 10 6.14e-01 7.47e-01 0.24200 0.179000 1.63e-01 3.27e-01 3.73e-01
Signaling by Hippo 19 3.75e-01 5.55e-01 0.24200 -0.186000 -1.55e-01 1.61e-01 2.43e-01
Signaling by NODAL 21 3.15e-02 1.20e-01 0.24100 -0.065800 -2.32e-01 6.02e-01 6.57e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression 27 2.33e-01 4.15e-01 0.24100 -0.189000 -1.49e-01 8.91e-02 1.81e-01
DAG and IP3 signaling 39 7.29e-03 4.34e-02 0.24000 -0.224000 -8.71e-02 1.56e-02 3.47e-01
TNFR1-induced NFkappaB signaling pathway 22 3.31e-01 5.16e-01 0.24000 0.155000 1.83e-01 2.08e-01 1.37e-01
Metabolism of cofactors 19 4.03e-01 5.84e-01 0.24000 0.177000 1.62e-01 1.82e-01 2.22e-01
Resolution of Abasic Sites (AP sites) 37 1.03e-01 2.59e-01 0.23900 0.196000 1.37e-01 3.89e-02 1.48e-01
Transcriptional regulation of white adipocyte differentiation 81 8.72e-03 4.92e-02 0.23900 0.140000 1.94e-01 2.92e-02 2.59e-03
Signaling by WNT in cancer 32 7.52e-02 2.11e-01 0.23900 0.118000 2.08e-01 2.49e-01 4.18e-02
Inflammasomes 21 3.75e-01 5.55e-01 0.23900 0.173000 1.65e-01 1.71e-01 1.90e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 3.00e-01 4.86e-01 0.23800 0.186000 1.48e-01 1.22e-01 2.18e-01
Cellular response to starvation 147 1.64e-04 2.38e-03 0.23800 0.194000 1.38e-01 4.83e-05 3.89e-03
KSRP (KHSRP) binds and destabilizes mRNA 17 1.74e-01 3.50e-01 0.23800 -0.100000 -2.16e-01 4.74e-01 1.23e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 14 4.74e-01 6.51e-01 0.23800 -0.188000 -1.46e-01 2.24e-01 3.43e-01
Diseases of hemostasis 14 4.74e-01 6.51e-01 0.23800 -0.188000 -1.46e-01 2.24e-01 3.43e-01
Early SARS-CoV-2 Infection Events 34 5.58e-02 1.78e-01 0.23700 0.113000 2.09e-01 2.54e-01 3.51e-02
Visual phototransduction 93 6.58e-03 4.05e-02 0.23700 -0.188000 -1.44e-01 1.68e-03 1.63e-02
Negative regulators of DDX58/IFIH1 signaling 34 2.04e-01 3.89e-01 0.23700 0.175000 1.60e-01 7.73e-02 1.07e-01
Cap-dependent Translation Initiation 111 2.63e-04 3.18e-03 0.23700 0.203000 1.21e-01 2.12e-04 2.77e-02
Eukaryotic Translation Initiation 111 2.63e-04 3.18e-03 0.23700 0.203000 1.21e-01 2.12e-04 2.77e-02
B-WICH complex positively regulates rRNA expression 29 2.07e-01 3.92e-01 0.23700 0.188000 1.43e-01 7.92e-02 1.82e-01
Negative regulation of MET activity 20 2.63e-01 4.50e-01 0.23600 0.128000 1.99e-01 3.22e-01 1.24e-01
Ion channel transport 168 1.55e-04 2.31e-03 0.23600 -0.186000 -1.45e-01 3.14e-05 1.18e-03
Thrombin signalling through proteinase activated receptors (PARs) 32 9.70e-02 2.49e-01 0.23600 0.121000 2.02e-01 2.35e-01 4.78e-02
Toll Like Receptor 3 (TLR3) Cascade 99 5.33e-03 3.46e-02 0.23600 0.144000 1.87e-01 1.33e-02 1.32e-03
Calcitonin-like ligand receptors 10 5.64e-01 7.13e-01 0.23500 -0.137000 -1.91e-01 4.52e-01 2.96e-01
L13a-mediated translational silencing of Ceruloplasmin expression 103 4.35e-04 4.60e-03 0.23500 0.203000 1.18e-01 3.73e-04 3.84e-02
RNA Polymerase II Transcription Termination 62 5.94e-02 1.85e-01 0.23400 0.173000 1.59e-01 1.88e-02 3.06e-02
VxPx cargo-targeting to cilium 20 3.56e-01 5.39e-01 0.23400 -0.185000 -1.44e-01 1.53e-01 2.65e-01
Synthesis of very long-chain fatty acyl-CoAs 23 1.76e-01 3.53e-01 0.23400 -0.203000 -1.17e-01 9.26e-02 3.30e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 3.09e-01 4.96e-01 0.23400 0.131000 1.94e-01 3.24e-01 1.43e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 3.09e-01 4.96e-01 0.23400 0.131000 1.94e-01 3.24e-01 1.43e-01
MyD88-independent TLR4 cascade 103 5.59e-03 3.56e-02 0.23400 0.146000 1.83e-01 1.06e-02 1.32e-03
TRIF(TICAM1)-mediated TLR4 signaling 103 5.59e-03 3.56e-02 0.23400 0.146000 1.83e-01 1.06e-02 1.32e-03
Glutathione conjugation 36 1.17e-01 2.79e-01 0.23400 0.192000 1.33e-01 4.56e-02 1.68e-01
EPHA-mediated growth cone collapse 15 3.13e-01 5.00e-01 0.23300 -0.203000 -1.15e-01 1.74e-01 4.42e-01
Signaling by FLT3 fusion proteins 19 2.10e-01 3.95e-01 0.23300 0.110000 2.05e-01 4.06e-01 1.22e-01
HIV elongation arrest and recovery 29 1.80e-01 3.59e-01 0.23300 0.191000 1.32e-01 7.43e-02 2.19e-01
Pausing and recovery of HIV elongation 29 1.80e-01 3.59e-01 0.23300 0.191000 1.32e-01 7.43e-02 2.19e-01
Formation of Fibrin Clot (Clotting Cascade) 37 1.28e-01 3.00e-01 0.23200 -0.188000 -1.36e-01 4.75e-02 1.52e-01
Separation of Sister Chromatids 161 9.04e-04 8.96e-03 0.23200 0.163000 1.64e-01 3.43e-04 3.19e-04
Regulation of TP53 Activity through Phosphorylation 88 1.88e-02 8.55e-02 0.23200 0.173000 1.54e-01 5.00e-03 1.25e-02
O-linked glycosylation 107 1.76e-04 2.47e-03 0.23200 -0.204000 -1.10e-01 2.68e-04 4.93e-02
RNA Polymerase II Pre-transcription Events 73 3.97e-02 1.42e-01 0.23100 0.170000 1.57e-01 1.21e-02 2.02e-02
Transcriptional Regulation by TP53 346 2.62e-07 1.50e-05 0.23100 0.170000 1.57e-01 5.19e-08 5.40e-07
L1CAM interactions 92 2.01e-03 1.65e-02 0.23100 -0.197000 -1.21e-01 1.11e-03 4.47e-02
Oxidative Stress Induced Senescence 66 1.15e-02 6.09e-02 0.23100 0.121000 1.97e-01 8.97e-02 5.74e-03
Post-translational modification: synthesis of GPI-anchored proteins 89 1.64e-02 7.74e-02 0.23100 -0.149000 -1.76e-01 1.48e-02 4.14e-03
CaM pathway 33 1.61e-02 7.64e-02 0.23000 -0.217000 -7.79e-02 3.10e-02 4.39e-01
Calmodulin induced events 33 1.61e-02 7.64e-02 0.23000 -0.217000 -7.79e-02 3.10e-02 4.39e-01
Regulation of PTEN mRNA translation 25 3.18e-01 5.04e-01 0.23000 0.150000 1.75e-01 1.96e-01 1.30e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 20 4.21e-01 5.98e-01 0.23000 -0.159000 -1.66e-01 2.17e-01 1.99e-01
Trafficking of GluR2-containing AMPA receptors 15 2.33e-01 4.15e-01 0.23000 -0.209000 -9.60e-02 1.61e-01 5.20e-01
HSF1 activation 27 1.46e-01 3.16e-01 0.23000 0.198000 1.17e-01 7.48e-02 2.94e-01
Negative regulation of FGFR4 signaling 30 6.13e-02 1.89e-01 0.23000 0.207000 9.87e-02 4.92e-02 3.49e-01
TP53 Regulates Transcription of Cell Cycle Genes 49 1.17e-01 2.80e-01 0.22900 0.169000 1.55e-01 4.04e-02 6.04e-02
Diseases associated with visual transduction 11 5.99e-01 7.36e-01 0.22900 -0.176000 -1.47e-01 3.11e-01 3.99e-01
Diseases of the neuronal system 11 5.99e-01 7.36e-01 0.22900 -0.176000 -1.47e-01 3.11e-01 3.99e-01
Retinoid cycle disease events 11 5.99e-01 7.36e-01 0.22900 -0.176000 -1.47e-01 3.11e-01 3.99e-01
Degradation of beta-catenin by the destruction complex 81 3.09e-02 1.19e-01 0.22900 0.166000 1.58e-01 9.95e-03 1.36e-02
CLEC7A (Dectin-1) signaling 96 1.62e-02 7.67e-02 0.22900 0.166000 1.58e-01 4.91e-03 7.48e-03
Polymerase switching on the C-strand of the telomere 24 3.18e-01 5.04e-01 0.22900 0.143000 1.78e-01 2.24e-01 1.31e-01
Triglyceride catabolism 23 1.78e-01 3.56e-01 0.22900 -0.199000 -1.12e-01 9.80e-02 3.53e-01
Transcriptional regulation of pluripotent stem cells 30 2.74e-01 4.63e-01 0.22800 0.156000 1.67e-01 1.40e-01 1.13e-01
PCP/CE pathway 90 1.80e-02 8.30e-02 0.22800 0.173000 1.50e-01 4.66e-03 1.41e-02
Ribavirin ADME 11 3.71e-01 5.52e-01 0.22800 0.099200 2.05e-01 5.69e-01 2.38e-01
UCH proteinases 81 1.86e-02 8.50e-02 0.22700 0.180000 1.38e-01 5.11e-03 3.12e-02
Zinc influx into cells by the SLC39 gene family 10 1.36e-01 3.06e-01 0.22700 0.225000 3.20e-02 2.18e-01 8.61e-01
Acyl chain remodelling of PG 18 3.78e-01 5.56e-01 0.22700 -0.185000 -1.32e-01 1.74e-01 3.34e-01
Pentose phosphate pathway 12 6.01e-01 7.37e-01 0.22700 0.155000 1.66e-01 3.53e-01 3.21e-01
Eicosanoid ligand-binding receptors 14 5.13e-01 6.75e-01 0.22600 0.140000 1.78e-01 3.63e-01 2.50e-01
Transcription of the HIV genome 62 7.49e-02 2.11e-01 0.22600 0.157000 1.63e-01 3.21e-02 2.67e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 12 5.40e-01 6.95e-01 0.22600 0.182000 1.34e-01 2.75e-01 4.22e-01
Cytosolic iron-sulfur cluster assembly 10 1.52e-02 7.35e-02 0.22600 0.206000 -9.17e-02 2.59e-01 6.15e-01
Cell Cycle, Mitotic 476 3.72e-09 4.11e-07 0.22500 0.157000 1.62e-01 4.47e-09 1.33e-09
Regulation of localization of FOXO transcription factors 11 5.50e-01 7.01e-01 0.22500 -0.184000 -1.29e-01 2.90e-01 4.60e-01
Signaling by FGFR3 39 3.51e-02 1.30e-01 0.22400 0.202000 9.86e-02 2.94e-02 2.86e-01
M Phase 335 9.83e-07 4.00e-05 0.22400 0.152000 1.65e-01 1.75e-06 1.94e-07
HS-GAG biosynthesis 28 7.02e-02 2.03e-01 0.22400 -0.204000 -9.13e-02 6.14e-02 4.03e-01
Activated NTRK2 signals through FRS2 and FRS3 11 6.26e-01 7.57e-01 0.22300 0.168000 1.47e-01 3.34e-01 3.98e-01
NF-kB is activated and signals survival 12 2.86e-01 4.72e-01 0.22300 0.207000 8.43e-02 2.15e-01 6.13e-01
Attenuation phase 25 1.05e-01 2.60e-01 0.22300 0.202000 9.38e-02 8.02e-02 4.17e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 93 2.04e-02 8.98e-02 0.22200 0.146000 1.67e-01 1.49e-02 5.36e-03
RNA Polymerase I Transcription 47 4.18e-02 1.47e-01 0.22100 0.192000 1.11e-01 2.30e-02 1.88e-01
Gap junction trafficking 27 1.52e-01 3.23e-01 0.22100 -0.192000 -1.08e-01 8.35e-02 3.31e-01
Recognition of DNA damage by PCNA-containing replication complex 29 2.24e-01 4.06e-01 0.22000 0.127000 1.80e-01 2.38e-01 9.31e-02
Heme biosynthesis 13 5.23e-01 6.82e-01 0.22000 -0.178000 -1.29e-01 2.66e-01 4.22e-01
Pre-NOTCH Processing in Golgi 18 7.40e-02 2.09e-01 0.21900 0.212000 5.47e-02 1.19e-01 6.88e-01
Signaling by Activin 15 5.33e-03 3.46e-02 0.21900 0.059200 -2.11e-01 6.91e-01 1.57e-01
Gap junction degradation 10 4.70e-01 6.47e-01 0.21900 -0.194000 -1.01e-01 2.89e-01 5.80e-01
RNA Polymerase I Promoter Clearance 46 4.33e-02 1.52e-01 0.21800 0.190000 1.06e-01 2.58e-02 2.12e-01
PLC beta mediated events 47 2.74e-03 2.13e-02 0.21700 -0.208000 -6.45e-02 1.37e-02 4.44e-01
Activation of SMO 17 4.52e-01 6.31e-01 0.21700 0.174000 1.30e-01 2.14e-01 3.52e-01
Nuclear signaling by ERBB4 32 1.36e-01 3.06e-01 0.21700 -0.187000 -1.12e-01 6.76e-02 2.75e-01
SHC1 events in EGFR signaling 14 4.92e-01 6.61e-01 0.21700 0.124000 1.78e-01 4.20e-01 2.49e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 5.56e-01 7.05e-01 0.21700 0.160000 1.46e-01 2.83e-01 3.27e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 49 1.05e-01 2.62e-01 0.21700 0.131000 1.73e-01 1.14e-01 3.60e-02
Negative regulation of FGFR2 signaling 33 4.50e-02 1.56e-01 0.21700 0.199000 8.46e-02 4.75e-02 4.00e-01
Homology Directed Repair 99 2.14e-02 9.28e-02 0.21600 0.146000 1.60e-01 1.23e-02 5.99e-03
Downstream signaling events of B Cell Receptor (BCR) 78 4.90e-02 1.65e-01 0.21600 0.145000 1.59e-01 2.64e-02 1.49e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 87 1.24e-02 6.42e-02 0.21600 0.177000 1.23e-01 4.24e-03 4.78e-02
FGFRL1 modulation of FGFR1 signaling 13 5.57e-03 3.56e-02 0.21500 0.103000 -1.88e-01 5.18e-01 2.40e-01
Killing mechanisms 11 1.45e-01 3.16e-01 0.21500 0.212000 3.22e-02 2.23e-01 8.53e-01
WNT5:FZD7-mediated leishmania damping 11 1.45e-01 3.16e-01 0.21500 0.212000 3.22e-02 2.23e-01 8.53e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 28 2.93e-01 4.79e-01 0.21400 -0.170000 -1.31e-01 1.20e-01 2.30e-01
Nucleotide-like (purinergic) receptors 13 6.14e-01 7.47e-01 0.21400 -0.149000 -1.54e-01 3.51e-01 3.37e-01
Class I peroxisomal membrane protein import 19 4.92e-01 6.61e-01 0.21400 0.149000 1.54e-01 2.62e-01 2.47e-01
Mitochondrial biogenesis 69 6.37e-02 1.93e-01 0.21400 0.138000 1.63e-01 4.80e-02 1.89e-02
Pyroptosis 26 8.07e-02 2.20e-01 0.21300 0.079000 1.98e-01 4.86e-01 8.09e-02
Cell Cycle 601 2.80e-10 3.61e-08 0.21200 0.144000 1.56e-01 1.58e-09 5.38e-11
HDR through MMEJ (alt-NHEJ) 11 6.06e-01 7.41e-01 0.21200 0.125000 1.71e-01 4.72e-01 3.26e-01
Regulation of KIT signaling 16 4.89e-01 6.61e-01 0.21200 -0.170000 -1.27e-01 2.39e-01 3.81e-01
Interleukin-12 signaling 43 1.64e-01 3.40e-01 0.21200 0.131000 1.67e-01 1.39e-01 5.85e-02
Dual Incision in GG-NER 39 1.34e-01 3.05e-01 0.21100 0.116000 1.76e-01 2.08e-01 5.69e-02
HS-GAG degradation 18 5.07e-01 6.73e-01 0.21100 -0.140000 -1.58e-01 3.04e-01 2.46e-01
Protein methylation 16 5.23e-01 6.83e-01 0.21100 0.164000 1.32e-01 2.56e-01 3.60e-01
Phospholipase C-mediated cascade: FGFR1 16 2.74e-03 2.13e-02 0.21100 0.191000 -8.89e-02 1.86e-01 5.38e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 2.43e-01 4.25e-01 0.21100 0.192000 8.66e-02 1.70e-01 5.36e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 75 6.61e-02 1.95e-01 0.21000 0.153000 1.44e-01 2.20e-02 3.10e-02
Cellular responses to stress 682 2.19e-11 3.76e-09 0.21000 0.156000 1.40e-01 3.30e-12 3.83e-10
Synaptic adhesion-like molecules 19 4.21e-01 5.98e-01 0.21000 -0.122000 -1.70e-01 3.56e-01 1.99e-01
Regulation of HSF1-mediated heat shock response 78 3.80e-02 1.38e-01 0.20900 0.166000 1.28e-01 1.12e-02 5.11e-02
Regulation of IFNA/IFNB signaling 22 1.24e-01 2.95e-01 0.20900 -0.077000 -1.95e-01 5.32e-01 1.14e-01
Integrin cell surface interactions 66 8.61e-02 2.29e-01 0.20900 -0.157000 -1.38e-01 2.72e-02 5.26e-02
RND2 GTPase cycle 42 1.65e-01 3.42e-01 0.20900 -0.167000 -1.26e-01 6.09e-02 1.59e-01
Inwardly rectifying K+ channels 35 1.60e-01 3.35e-01 0.20900 -0.176000 -1.13e-01 7.18e-02 2.47e-01
SUMOylation of DNA damage response and repair proteins 71 6.87e-02 2.01e-01 0.20900 0.135000 1.59e-01 4.87e-02 2.07e-02
Synthesis of bile acids and bile salts 34 1.20e-03 1.09e-02 0.20800 -0.208000 -1.25e-02 3.57e-02 9.00e-01
Phospholipase C-mediated cascade; FGFR3 12 1.96e-02 8.79e-02 0.20800 0.198000 -6.41e-02 2.34e-01 7.01e-01
Formation of the ternary complex, and subsequently, the 43S complex 46 5.19e-02 1.71e-01 0.20800 0.183000 1.00e-01 3.20e-02 2.40e-01
Unfolded Protein Response (UPR) 90 1.76e-02 8.14e-02 0.20800 0.169000 1.21e-01 5.52e-03 4.63e-02
NOTCH1 Intracellular Domain Regulates Transcription 44 1.56e-01 3.29e-01 0.20800 0.125000 1.66e-01 1.51e-01 5.70e-02
Cellular responses to stimuli 696 1.50e-11 2.91e-09 0.20700 0.156000 1.36e-01 1.82e-12 8.31e-10
COPI-independent Golgi-to-ER retrograde traffic 34 2.93e-01 4.79e-01 0.20700 -0.155000 -1.38e-01 1.19e-01 1.63e-01
FRS-mediated FGFR3 signaling 19 8.69e-02 2.30e-01 0.20700 0.200000 5.20e-02 1.30e-01 6.95e-01
Regulation of RUNX2 expression and activity 71 8.28e-02 2.24e-01 0.20700 0.150000 1.43e-01 2.89e-02 3.72e-02
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 10 4.92e-01 6.61e-01 0.20700 0.185000 9.30e-02 3.11e-01 6.11e-01
Ethanol oxidation 12 6.55e-01 7.75e-01 0.20700 -0.151000 -1.41e-01 3.64e-01 3.99e-01
ERK/MAPK targets 20 4.83e-01 6.59e-01 0.20700 0.156000 1.36e-01 2.28e-01 2.92e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 6.16e-02 1.90e-01 0.20700 0.132000 1.59e-01 4.90e-02 1.82e-02
Transport of organic anions 10 5.08e-01 6.73e-01 0.20600 -0.183000 -9.50e-02 3.16e-01 6.03e-01
Mitotic G2-G2/M phases 177 2.05e-03 1.68e-02 0.20600 0.140000 1.51e-01 1.34e-03 5.05e-04
Paracetamol ADME 27 2.28e-02 9.70e-02 0.20600 -0.201000 -4.36e-02 7.02e-02 6.95e-01
Beta-catenin phosphorylation cascade 16 3.80e-01 5.58e-01 0.20500 0.101000 1.79e-01 4.86e-01 2.15e-01
ADP signalling through P2Y purinoceptor 1 25 1.39e-01 3.10e-01 0.20500 0.084600 1.87e-01 4.64e-01 1.05e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 34 3.12e-01 4.99e-01 0.20500 0.146000 1.44e-01 1.41e-01 1.46e-01
Presynaptic nicotinic acetylcholine receptors 12 1.46e-01 3.16e-01 0.20500 0.203000 3.04e-02 2.24e-01 8.55e-01
Formation of HIV elongation complex in the absence of HIV Tat 40 2.17e-01 4.03e-01 0.20500 0.159000 1.28e-01 8.10e-02 1.60e-01
Late endosomal microautophagy 32 1.33e-01 3.04e-01 0.20500 0.097300 1.80e-01 3.41e-01 7.80e-02
Triglyceride metabolism 36 2.76e-01 4.63e-01 0.20500 -0.154000 -1.34e-01 1.09e-01 1.63e-01
FGFR1 ligand binding and activation 15 7.57e-03 4.41e-02 0.20400 0.192000 -7.00e-02 1.98e-01 6.39e-01
p75NTR recruits signalling complexes 12 3.48e-01 5.34e-01 0.20400 0.189000 7.63e-02 2.56e-01 6.47e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 15 6.45e-02 1.94e-01 0.20400 0.016000 2.03e-01 9.14e-01 1.73e-01
FGFR3 mutant receptor activation 11 5.07e-02 1.67e-01 0.20400 0.200000 -3.60e-02 2.50e-01 8.36e-01
Signaling by activated point mutants of FGFR3 11 5.07e-02 1.67e-01 0.20400 0.200000 -3.60e-02 2.50e-01 8.36e-01
G2/M Transition 175 2.50e-03 1.98e-02 0.20300 0.137000 1.50e-01 1.75e-03 6.03e-04
Cytosolic sensors of pathogen-associated DNA 60 1.04e-01 2.60e-01 0.20300 0.128000 1.58e-01 8.75e-02 3.38e-02
trans-Golgi Network Vesicle Budding 67 1.00e-01 2.54e-01 0.20300 0.137000 1.50e-01 5.32e-02 3.34e-02
Glycogen storage diseases 14 7.96e-02 2.19e-01 0.20300 0.015800 2.02e-01 9.18e-01 1.90e-01
Formation of RNA Pol II elongation complex 53 1.30e-01 3.01e-01 0.20300 0.159000 1.25e-01 4.46e-02 1.16e-01
RNA Polymerase II Transcription Elongation 53 1.30e-01 3.01e-01 0.20300 0.159000 1.25e-01 4.46e-02 1.16e-01
Regulation of signaling by CBL 18 2.05e-01 3.89e-01 0.20200 -0.188000 -7.46e-02 1.67e-01 5.84e-01
RIP-mediated NFkB activation via ZBP1 16 5.74e-01 7.21e-01 0.20200 0.134000 1.52e-01 3.53e-01 2.94e-01
Gap junction trafficking and regulation 29 1.83e-01 3.61e-01 0.20200 -0.176000 -9.91e-02 1.00e-01 3.56e-01
Signaling by FGFR4 in disease 11 6.61e-01 7.77e-01 0.20200 -0.126000 -1.58e-01 4.70e-01 3.64e-01
Cyclin A/B1/B2 associated events during G2/M transition 24 3.18e-01 5.04e-01 0.20200 0.169000 1.10e-01 1.52e-01 3.49e-01
Heparan sulfate/heparin (HS-GAG) metabolism 49 1.74e-01 3.50e-01 0.20200 -0.154000 -1.29e-01 6.14e-02 1.17e-01
Regulation of FZD by ubiquitination 21 2.05e-01 3.89e-01 0.20100 0.083500 1.83e-01 5.08e-01 1.46e-01
Interleukin-1 signaling 109 2.41e-02 9.96e-02 0.20100 0.133000 1.51e-01 1.62e-02 6.52e-03
MAP2K and MAPK activation 36 1.68e-01 3.46e-01 0.20000 0.107000 1.70e-01 2.68e-01 7.83e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 106 2.54e-02 1.02e-01 0.20000 0.130000 1.52e-01 2.06e-02 6.75e-03
Toll Like Receptor 2 (TLR2) Cascade 106 2.54e-02 1.02e-01 0.20000 0.130000 1.52e-01 2.06e-02 6.75e-03
Toll Like Receptor TLR1:TLR2 Cascade 106 2.54e-02 1.02e-01 0.20000 0.130000 1.52e-01 2.06e-02 6.75e-03
Toll Like Receptor TLR6:TLR2 Cascade 106 2.54e-02 1.02e-01 0.20000 0.130000 1.52e-01 2.06e-02 6.75e-03
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 15 5.02e-01 6.68e-01 0.20000 0.111000 1.67e-01 4.57e-01 2.64e-01
Signaling by FGFR4 40 8.42e-02 2.26e-01 0.20000 0.177000 9.38e-02 5.30e-02 3.05e-01
Smooth Muscle Contraction 43 1.99e-01 3.82e-01 0.20000 -0.158000 -1.23e-01 7.37e-02 1.62e-01
Miscellaneous substrates 12 6.75e-01 7.84e-01 0.20000 -0.138000 -1.44e-01 4.07e-01 3.87e-01
HCMV Early Events 55 6.28e-02 1.93e-01 0.19900 0.104000 1.70e-01 1.81e-01 2.96e-02
Adenylate cyclase inhibitory pathway 14 6.24e-01 7.55e-01 0.19900 -0.150000 -1.31e-01 3.33e-01 3.96e-01
Inositol phosphate metabolism 45 2.33e-01 4.15e-01 0.19900 -0.137000 -1.44e-01 1.13e-01 9.44e-02
Tryptophan catabolism 12 3.18e-01 5.04e-01 0.19800 -0.187000 -6.52e-02 2.61e-01 6.96e-01
Drug ADME 104 1.28e-02 6.57e-02 0.19800 -0.162000 -1.14e-01 4.21e-03 4.48e-02
DNA Repair 276 1.31e-04 2.03e-03 0.19800 0.134000 1.46e-01 1.29e-04 2.82e-05
Condensation of Prophase Chromosomes 12 2.14e-01 4.00e-01 0.19800 0.042800 1.93e-01 7.97e-01 2.46e-01
Ub-specific processing proteases 153 7.88e-03 4.50e-02 0.19800 0.139000 1.41e-01 3.05e-03 2.66e-03
Toll Like Receptor 4 (TLR4) Cascade 135 7.47e-03 4.39e-02 0.19700 0.122000 1.55e-01 1.43e-02 1.84e-03
HDR through Single Strand Annealing (SSA) 36 3.05e-01 4.93e-01 0.19700 0.131000 1.48e-01 1.75e-01 1.25e-01
Processing of SMDT1 15 5.81e-01 7.25e-01 0.19700 -0.155000 -1.22e-01 2.99e-01 4.15e-01
Cytosolic sulfonation of small molecules 21 3.33e-01 5.19e-01 0.19700 0.170000 9.94e-02 1.79e-01 4.30e-01
Acetylcholine Neurotransmitter Release Cycle 16 6.00e-01 7.36e-01 0.19600 -0.133000 -1.44e-01 3.55e-01 3.18e-01
Ephrin signaling 17 5.12e-01 6.75e-01 0.19600 -0.116000 -1.59e-01 4.09e-01 2.57e-01
RHO GTPases activate CIT 19 5.27e-01 6.86e-01 0.19600 -0.126000 -1.50e-01 3.40e-01 2.58e-01
Neddylation 228 6.93e-04 6.96e-03 0.19600 0.145000 1.31e-01 1.52e-04 6.18e-04
Toll-like Receptor Cascades 154 3.46e-03 2.55e-02 0.19600 0.119000 1.56e-01 1.07e-02 8.50e-04
Formation of the Early Elongation Complex 32 3.62e-01 5.45e-01 0.19600 0.144000 1.33e-01 1.59e-01 1.94e-01
Formation of the HIV-1 Early Elongation Complex 32 3.62e-01 5.45e-01 0.19600 0.144000 1.33e-01 1.59e-01 1.94e-01
FRS-mediated FGFR1 signaling 23 2.03e-02 8.96e-02 0.19600 0.195000 1.45e-02 1.05e-01 9.04e-01
Metabolic disorders of biological oxidation enzymes 32 2.47e-01 4.29e-01 0.19500 -0.108000 -1.63e-01 2.91e-01 1.11e-01
VLDLR internalisation and degradation 16 5.31e-01 6.89e-01 0.19500 0.158000 1.13e-01 2.73e-01 4.33e-01
Interleukin-6 family signaling 24 4.48e-01 6.29e-01 0.19500 -0.149000 -1.25e-01 2.05e-01 2.90e-01
Signaling by ROBO receptors 203 1.85e-03 1.55e-02 0.19300 0.143000 1.30e-01 4.35e-04 1.37e-03
Signalling to RAS 20 4.30e-01 6.08e-01 0.19300 0.160000 1.08e-01 2.14e-01 4.04e-01
SHC-mediated cascade:FGFR4 19 1.55e-01 3.26e-01 0.19300 0.184000 5.81e-02 1.64e-01 6.61e-01
RHOB GTPase cycle 66 4.44e-03 3.06e-02 0.19300 -0.180000 -6.93e-02 1.15e-02 3.30e-01
HIV Transcription Initiation 43 2.21e-01 4.05e-01 0.19200 0.117000 1.52e-01 1.83e-01 8.47e-02
RNA Polymerase II HIV Promoter Escape 43 2.21e-01 4.05e-01 0.19200 0.117000 1.52e-01 1.83e-01 8.47e-02
RNA Polymerase II Promoter Escape 43 2.21e-01 4.05e-01 0.19200 0.117000 1.52e-01 1.83e-01 8.47e-02
RNA Polymerase II Transcription Initiation 43 2.21e-01 4.05e-01 0.19200 0.117000 1.52e-01 1.83e-01 8.47e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 43 2.21e-01 4.05e-01 0.19200 0.117000 1.52e-01 1.83e-01 8.47e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 43 2.21e-01 4.05e-01 0.19200 0.117000 1.52e-01 1.83e-01 8.47e-02
FGFR1 mutant receptor activation 30 4.06e-01 5.87e-01 0.19200 0.134000 1.37e-01 2.04e-01 1.94e-01
Crosslinking of collagen fibrils 10 6.12e-01 7.47e-01 0.19100 -0.097500 -1.65e-01 5.94e-01 3.67e-01
MAP kinase activation 58 7.11e-02 2.04e-01 0.19100 0.101000 1.62e-01 1.83e-01 3.26e-02
GPVI-mediated activation cascade 32 2.56e-01 4.43e-01 0.19100 0.104000 1.60e-01 3.06e-01 1.18e-01
Glycolysis 68 1.31e-01 3.01e-01 0.19100 0.130000 1.39e-01 6.31e-02 4.72e-02
Transcriptional regulation by RUNX3 93 6.31e-02 1.93e-01 0.19100 0.131000 1.38e-01 2.86e-02 2.13e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 6.59e-01 7.76e-01 0.19100 0.131000 1.38e-01 3.96e-01 3.70e-01
eNOS activation 11 6.99e-01 8.03e-01 0.19000 -0.121000 -1.47e-01 4.88e-01 3.97e-01
Serotonin receptors 11 6.32e-01 7.60e-01 0.19000 -0.159000 -1.05e-01 3.62e-01 5.46e-01
RHOBTB1 GTPase cycle 22 8.84e-02 2.33e-01 0.19000 0.046300 1.84e-01 7.07e-01 1.34e-01
Ion homeostasis 50 2.31e-01 4.14e-01 0.19000 -0.136000 -1.33e-01 9.73e-02 1.04e-01
Cellular response to heat stress 95 4.94e-02 1.66e-01 0.18900 0.146000 1.21e-01 1.42e-02 4.09e-02
Prolonged ERK activation events 14 6.46e-01 7.67e-01 0.18900 -0.123000 -1.44e-01 4.26e-01 3.50e-01
Translesion synthesis by POLK 17 4.66e-01 6.44e-01 0.18900 0.099600 1.61e-01 4.77e-01 2.51e-01
Triglyceride biosynthesis 13 3.97e-01 5.78e-01 0.18900 -0.074300 -1.74e-01 6.43e-01 2.78e-01
Regulation of NPAS4 gene expression 13 3.84e-01 5.64e-01 0.18900 -0.175000 -7.22e-02 2.76e-01 6.52e-01
Aflatoxin activation and detoxification 19 5.19e-01 6.81e-01 0.18900 -0.114000 -1.50e-01 3.88e-01 2.57e-01
Metabolism of nucleotides 95 5.72e-02 1.81e-01 0.18800 0.142000 1.24e-01 1.70e-02 3.71e-02
Global Genome Nucleotide Excision Repair (GG-NER) 81 9.25e-02 2.40e-01 0.18800 0.139000 1.26e-01 3.03e-02 5.02e-02
FGFR2b ligand binding and activation 10 6.55e-01 7.75e-01 0.18700 -0.158000 -1.01e-01 3.88e-01 5.80e-01
Chromosome Maintenance 86 8.57e-02 2.29e-01 0.18700 0.130000 1.35e-01 3.69e-02 3.10e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 14 2.90e-01 4.78e-01 0.18700 -0.177000 -5.85e-02 2.51e-01 7.05e-01
RND3 GTPase cycle 41 2.34e-02 9.86e-02 0.18700 -0.178000 -5.59e-02 4.86e-02 5.36e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 24 6.85e-03 4.20e-02 0.18600 -0.185000 2.04e-02 1.16e-01 8.62e-01
SARS-CoV-2-host interactions 183 5.82e-03 3.66e-02 0.18600 0.133000 1.30e-01 1.88e-03 2.38e-03
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 117 3.05e-02 1.18e-01 0.18600 -0.141000 -1.20e-01 8.25e-03 2.44e-02
WNT ligand biogenesis and trafficking 25 2.01e-01 3.84e-01 0.18600 0.169000 7.67e-02 1.43e-01 5.07e-01
AKT phosphorylates targets in the cytosol 14 6.71e-01 7.84e-01 0.18600 0.136000 1.26e-01 3.77e-01 4.14e-01
Platelet homeostasis 85 2.17e-02 9.38e-02 0.18500 -0.159000 -9.55e-02 1.12e-02 1.28e-01
SUMOylation 164 9.75e-03 5.38e-02 0.18500 0.125000 1.36e-01 5.89e-03 2.57e-03
Toll Like Receptor 9 (TLR9) Cascade 100 3.57e-02 1.32e-01 0.18500 0.111000 1.48e-01 5.49e-02 1.08e-02
Signaling by cytosolic FGFR1 fusion mutants 17 1.31e-01 3.01e-01 0.18500 0.034200 1.81e-01 8.07e-01 1.95e-01
Organic cation/anion/zwitterion transport 15 6.57e-01 7.75e-01 0.18400 -0.127000 -1.34e-01 3.96e-01 3.68e-01
Sema3A PAK dependent Axon repulsion 14 1.71e-01 3.49e-01 0.18400 -0.182000 -2.96e-02 2.38e-01 8.48e-01
CYP2E1 reactions 11 6.74e-01 7.84e-01 0.18400 -0.106000 -1.50e-01 5.42e-01 3.88e-01
SLC-mediated transmembrane transport 238 1.45e-03 1.26e-02 0.18400 -0.133000 -1.27e-01 4.09e-04 7.20e-04
TAK1-dependent IKK and NF-kappa-B activation 41 2.43e-01 4.25e-01 0.18300 0.108000 1.49e-01 2.33e-01 9.98e-02
Signal regulatory protein family interactions 13 6.15e-01 7.47e-01 0.18300 0.152000 1.03e-01 3.44e-01 5.20e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 15 1.33e-01 3.04e-01 0.18300 0.022900 1.82e-01 8.78e-01 2.23e-01
TP53 Regulates Transcription of DNA Repair Genes 57 1.11e-01 2.71e-01 0.18300 0.153000 1.01e-01 4.62e-02 1.87e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11 2.74e-01 4.62e-01 0.18300 -0.033600 -1.80e-01 8.47e-01 3.02e-01
G alpha (s) signalling events 153 4.00e-03 2.82e-02 0.18300 -0.150000 -1.04e-01 1.34e-03 2.66e-02
Platelet Adhesion to exposed collagen 13 4.49e-01 6.29e-01 0.18200 -0.166000 -7.53e-02 3.01e-01 6.38e-01
ERBB2 Regulates Cell Motility 15 2.13e-01 3.99e-01 0.18200 -0.177000 -4.28e-02 2.36e-01 7.74e-01
MAPK targets/ Nuclear events mediated by MAP kinases 29 4.33e-01 6.10e-01 0.18200 0.139000 1.17e-01 1.95e-01 2.76e-01
DNA strand elongation 31 2.33e-01 4.15e-01 0.18100 0.158000 8.92e-02 1.28e-01 3.90e-01
G-protein mediated events 52 7.54e-03 4.41e-02 0.18100 -0.174000 -4.84e-02 2.95e-02 5.46e-01
SHC-mediated cascade:FGFR2 22 1.07e-01 2.64e-01 0.18000 0.175000 4.25e-02 1.54e-01 7.30e-01
Pre-NOTCH Expression and Processing 61 1.99e-01 3.82e-01 0.18000 0.125000 1.30e-01 9.10e-02 8.01e-02
RNA Polymerase III Chain Elongation 18 6.19e-01 7.52e-01 0.17900 0.132000 1.22e-01 3.33e-01 3.72e-01
Synthesis of PE 12 2.79e-01 4.63e-01 0.17900 0.175000 3.77e-02 2.93e-01 8.21e-01
p75NTR signals via NF-kB 15 5.58e-01 7.07e-01 0.17900 0.151000 9.61e-02 3.11e-01 5.20e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 18 5.67e-01 7.16e-01 0.17900 0.143000 1.07e-01 2.93e-01 4.32e-01
Neuronal System 371 4.87e-06 1.48e-04 0.17800 -0.145000 -1.03e-01 1.47e-06 6.13e-04
SUMOylation of intracellular receptors 29 1.52e-01 3.23e-01 0.17800 0.068600 1.65e-01 5.22e-01 1.25e-01
Potential therapeutics for SARS 92 8.88e-02 2.34e-01 0.17800 0.120000 1.31e-01 4.59e-02 2.94e-02
Ribosomal scanning and start codon recognition 53 5.94e-02 1.85e-01 0.17800 0.159000 7.87e-02 4.47e-02 3.21e-01
MyD88 dependent cascade initiated on endosome 96 5.59e-02 1.78e-01 0.17800 0.108000 1.41e-01 6.66e-02 1.72e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade 96 5.59e-02 1.78e-01 0.17800 0.108000 1.41e-01 6.66e-02 1.72e-02
FCERI mediated Ca+2 mobilization 27 1.98e-01 3.81e-01 0.17700 -0.162000 -7.20e-02 1.45e-01 5.17e-01
Gene expression (Transcription) 1420 1.08e-15 3.34e-13 0.17700 0.124000 1.27e-01 3.43e-15 9.21e-16
Striated Muscle Contraction 33 4.19e-01 5.97e-01 0.17700 -0.132000 -1.18e-01 1.89e-01 2.41e-01
Erythropoietin activates RAS 14 6.32e-01 7.60e-01 0.17700 0.144000 1.02e-01 3.51e-01 5.07e-01
NOD1/2 Signaling Pathway 29 1.94e-01 3.76e-01 0.17700 0.074500 1.60e-01 4.87e-01 1.35e-01
Regulation of gene expression by Hypoxia-inducible Factor 11 7.02e-01 8.05e-01 0.17600 0.143000 1.03e-01 4.11e-01 5.53e-01
RHOV GTPase cycle 36 4.36e-02 1.52e-01 0.17600 -0.170000 -4.90e-02 7.83e-02 6.11e-01
Translesion synthesis by REV1 16 5.07e-01 6.73e-01 0.17600 0.088500 1.52e-01 5.40e-01 2.92e-01
Formation of TC-NER Pre-Incision Complex 51 1.83e-01 3.61e-01 0.17600 0.144000 1.01e-01 7.46e-02 2.14e-01
Reversible hydration of carbon dioxide 11 7.53e-01 8.39e-01 0.17600 0.118000 1.30e-01 4.97e-01 4.56e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 20 2.89e-01 4.76e-01 0.17600 0.068500 1.62e-01 5.96e-01 2.10e-01
NOTCH2 intracellular domain regulates transcription 11 5.02e-01 6.68e-01 0.17600 0.068000 1.62e-01 6.96e-01 3.52e-01
FGFR3 ligand binding and activation 12 4.64e-02 1.59e-01 0.17500 0.159000 -7.47e-02 3.42e-01 6.54e-01
FGFR3c ligand binding and activation 12 4.64e-02 1.59e-01 0.17500 0.159000 -7.47e-02 3.42e-01 6.54e-01
Response to metal ions 14 3.25e-02 1.22e-01 0.17500 0.163000 -6.47e-02 2.91e-01 6.75e-01
Mitotic Spindle Checkpoint 106 6.35e-02 1.93e-01 0.17500 0.115000 1.32e-01 4.05e-02 1.91e-02
Glycogen breakdown (glycogenolysis) 11 2.18e-01 4.03e-01 0.17400 -0.010400 -1.74e-01 9.53e-01 3.17e-01
mRNA Splicing - Minor Pathway 51 1.05e-01 2.60e-01 0.17400 0.152000 8.44e-02 5.97e-02 2.97e-01
Activation of GABAB receptors 43 1.71e-01 3.49e-01 0.17400 -0.150000 -8.79e-02 8.83e-02 3.19e-01
GABA B receptor activation 43 1.71e-01 3.49e-01 0.17400 -0.150000 -8.79e-02 8.83e-02 3.19e-01
Tight junction interactions 28 3.74e-01 5.55e-01 0.17400 -0.145000 -9.53e-02 1.84e-01 3.83e-01
Nicotinamide salvaging 17 5.43e-01 6.96e-01 0.17400 -0.146000 -9.40e-02 2.98e-01 5.02e-01
Common Pathway of Fibrin Clot Formation 21 3.97e-01 5.78e-01 0.17300 -0.152000 -8.38e-02 2.29e-01 5.06e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 7.80e-01 8.49e-01 0.17300 0.116000 1.28e-01 5.25e-01 4.84e-01
SUMO E3 ligases SUMOylate target proteins 158 2.03e-02 8.96e-02 0.17300 0.116000 1.27e-01 1.15e-02 5.67e-03
Fatty acids 15 4.67e-01 6.45e-01 0.17300 -0.076000 -1.55e-01 6.10e-01 2.99e-01
Post NMDA receptor activation events 58 9.11e-02 2.38e-01 0.17300 -0.150000 -8.61e-02 4.88e-02 2.57e-01
Pre-NOTCH Transcription and Translation 45 1.94e-01 3.76e-01 0.17200 0.092100 1.46e-01 2.85e-01 9.06e-02
Blood group systems biosynthesis 22 5.83e-01 7.28e-01 0.17200 -0.118000 -1.26e-01 3.38e-01 3.07e-01
Serotonin Neurotransmitter Release Cycle 16 5.02e-01 6.68e-01 0.17200 -0.151000 -8.38e-02 2.97e-01 5.61e-01
MAPK6/MAPK4 signaling 89 8.66e-02 2.30e-01 0.17200 0.135000 1.07e-01 2.75e-02 8.12e-02
SARS-CoV-2 activates/modulates innate and adaptive immune responses 110 5.99e-02 1.86e-01 0.17200 0.112000 1.31e-01 4.30e-02 1.77e-02
Phosphorylation of CD3 and TCR zeta chains 20 4.24e-01 6.02e-01 0.17200 -0.083600 -1.50e-01 5.18e-01 2.45e-01
Chemokine receptors bind chemokines 56 2.16e-01 4.02e-01 0.17200 -0.106000 -1.35e-01 1.68e-01 8.12e-02
Impaired BRCA2 binding to RAD51 33 4.06e-01 5.87e-01 0.17200 0.107000 1.35e-01 2.89e-01 1.81e-01
Endogenous sterols 26 2.03e-01 3.88e-01 0.17200 -0.159000 -6.50e-02 1.61e-01 5.66e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 1.88e-01 3.68e-01 0.17100 0.170000 2.02e-02 2.70e-01 8.96e-01
Fatty acyl-CoA biosynthesis 36 1.59e-01 3.33e-01 0.17100 -0.154000 -7.42e-02 1.09e-01 4.41e-01
Carboxyterminal post-translational modifications of tubulin 40 2.16e-01 4.02e-01 0.17100 -0.088300 -1.47e-01 3.34e-01 1.08e-01
Signaling by ALK fusions and activated point mutants 51 1.41e-01 3.12e-01 0.17100 0.087900 1.47e-01 2.77e-01 6.99e-02
Signaling by ALK in cancer 51 1.41e-01 3.12e-01 0.17100 0.087900 1.47e-01 2.77e-01 6.99e-02
MET receptor recycling 10 7.64e-01 8.39e-01 0.17000 0.133000 1.05e-01 4.65e-01 5.65e-01
CD209 (DC-SIGN) signaling 20 3.44e-01 5.30e-01 0.17000 -0.154000 -7.04e-02 2.32e-01 5.86e-01
RNA Polymerase II Transcription 1284 3.71e-13 8.20e-11 0.17000 0.120000 1.20e-01 3.46e-13 4.72e-13
InlB-mediated entry of Listeria monocytogenes into host cell 14 3.60e-01 5.44e-01 0.16900 0.052600 1.61e-01 7.33e-01 2.98e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 95 7.11e-02 2.04e-01 0.16900 0.102000 1.35e-01 8.59e-02 2.30e-02
Cholesterol biosynthesis 24 4.03e-01 5.84e-01 0.16900 0.145000 8.65e-02 2.18e-01 4.63e-01
Deubiquitination 226 3.88e-03 2.77e-02 0.16900 0.110000 1.28e-01 4.44e-03 8.66e-04
SARS-CoV Infections 387 1.13e-04 1.83e-03 0.16900 0.113000 1.25e-01 1.25e-04 2.32e-05
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 54 7.84e-02 2.18e-01 0.16900 0.151000 7.57e-02 5.50e-02 3.36e-01
Programmed Cell Death 192 9.82e-04 9.43e-03 0.16900 0.088000 1.44e-01 3.53e-02 5.89e-04
Tie2 Signaling 18 2.65e-01 4.52e-01 0.16800 0.051100 1.60e-01 7.07e-01 2.39e-01
Signaling by NTRK1 (TRKA) 114 6.97e-02 2.02e-01 0.16800 0.124000 1.14e-01 2.25e-02 3.54e-02
Interleukin-17 signaling 66 7.84e-02 2.18e-01 0.16800 0.084100 1.45e-01 2.37e-01 4.16e-02
Role of phospholipids in phagocytosis 23 3.03e-01 4.90e-01 0.16700 -0.152000 -6.95e-02 2.06e-01 5.64e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 4.09e-01 5.88e-01 0.16700 0.096000 1.37e-01 3.62e-01 1.95e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 15 6.62e-01 7.77e-01 0.16700 -0.134000 -1.00e-01 3.70e-01 5.02e-01
Telomere Extension By Telomerase 22 5.73e-01 7.20e-01 0.16700 0.105000 1.30e-01 3.96e-01 2.92e-01
Transport of bile salts and organic acids, metal ions and amine compounds 84 7.32e-02 2.07e-01 0.16600 -0.092900 -1.38e-01 1.41e-01 2.87e-02
Transcriptional activation of mitochondrial biogenesis 51 2.78e-01 4.63e-01 0.16600 0.105000 1.29e-01 1.96e-01 1.10e-01
Norepinephrine Neurotransmitter Release Cycle 16 6.75e-01 7.84e-01 0.16600 -0.128000 -1.06e-01 3.75e-01 4.63e-01
Neurotoxicity of clostridium toxins 10 7.71e-01 8.41e-01 0.16600 -0.102000 -1.31e-01 5.76e-01 4.73e-01
RHO GTPases Activate ROCKs 19 6.36e-01 7.63e-01 0.16600 -0.126000 -1.08e-01 3.42e-01 4.14e-01
DNA Double Strand Break Response 42 3.44e-01 5.30e-01 0.16600 0.103000 1.30e-01 2.49e-01 1.46e-01
Peroxisomal lipid metabolism 28 4.69e-01 6.46e-01 0.16600 0.132000 9.92e-02 2.25e-01 3.64e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 51 2.60e-01 4.47e-01 0.16500 0.100000 1.32e-01 2.16e-01 1.04e-01
Signaling by FGFR2 72 9.83e-02 2.51e-01 0.16500 0.139000 9.00e-02 4.19e-02 1.86e-01
HDR through Homologous Recombination (HRR) 64 2.20e-01 4.05e-01 0.16500 0.107000 1.26e-01 1.39e-01 8.17e-02
Activation of G protein gated Potassium channels 29 2.24e-01 4.06e-01 0.16500 -0.150000 -6.69e-02 1.61e-01 5.33e-01
G protein gated Potassium channels 29 2.24e-01 4.06e-01 0.16500 -0.150000 -6.69e-02 1.61e-01 5.33e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 29 2.24e-01 4.06e-01 0.16500 -0.150000 -6.69e-02 1.61e-01 5.33e-01
RNA Polymerase I Transcription Initiation 42 1.80e-01 3.59e-01 0.16400 0.145000 7.80e-02 1.05e-01 3.82e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 5.28e-01 6.87e-01 0.16400 0.131000 9.85e-02 2.65e-01 4.03e-01
Maturation of spike protein 9694548 35 4.14e-01 5.93e-01 0.16400 0.102000 1.29e-01 2.99e-01 1.86e-01
Glutathione synthesis and recycling 12 3.52e-01 5.35e-01 0.16400 0.160000 3.63e-02 3.37e-01 8.28e-01
ABC transporter disorders 75 1.44e-01 3.16e-01 0.16400 0.130000 9.94e-02 5.12e-02 1.37e-01
Potassium Channels 102 7.63e-02 2.14e-01 0.16300 -0.129000 -1.00e-01 2.42e-02 8.03e-02
PKA activation 18 1.94e-01 3.76e-01 0.16300 -0.160000 -3.23e-02 2.40e-01 8.12e-01
Transport of small molecules 689 2.62e-07 1.50e-05 0.16200 -0.123000 -1.06e-01 3.80e-08 2.09e-06
Lewis blood group biosynthesis 18 6.42e-01 7.67e-01 0.16100 -0.099000 -1.27e-01 4.67e-01 3.50e-01
Translation initiation complex formation 53 8.69e-02 2.30e-01 0.16100 0.146000 6.89e-02 6.65e-02 3.85e-01
FCGR3A-mediated IL10 synthesis 37 1.31e-01 3.01e-01 0.16100 -0.149000 -5.98e-02 1.16e-01 5.29e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 31 3.50e-01 5.34e-01 0.16100 0.138000 8.25e-02 1.85e-01 4.26e-01
RHO GTPases Activate NADPH Oxidases 22 5.41e-01 6.95e-01 0.16100 0.132000 9.15e-02 2.84e-01 4.57e-01
Frs2-mediated activation 12 6.66e-01 7.80e-01 0.16000 -0.082500 -1.38e-01 6.21e-01 4.09e-01
Generic Transcription Pathway 1163 8.13e-11 1.14e-08 0.16000 0.114000 1.12e-01 4.34e-11 9.54e-11
Diseases of DNA repair 49 3.49e-01 5.34e-01 0.16000 0.119000 1.07e-01 1.49e-01 1.96e-01
DNA Double-Strand Break Repair 129 3.78e-02 1.38e-01 0.16000 0.095300 1.28e-01 6.15e-02 1.17e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF) 54 2.78e-01 4.63e-01 0.15900 0.098300 1.25e-01 2.11e-01 1.11e-01
MyD88 cascade initiated on plasma membrane 91 7.99e-02 2.19e-01 0.15900 0.089600 1.31e-01 1.39e-01 3.06e-02
Toll Like Receptor 10 (TLR10) Cascade 91 7.99e-02 2.19e-01 0.15900 0.089600 1.31e-01 1.39e-01 3.06e-02
Toll Like Receptor 5 (TLR5) Cascade 91 7.99e-02 2.19e-01 0.15900 0.089600 1.31e-01 1.39e-01 3.06e-02
RORA activates gene expression 17 1.86e-01 3.66e-01 0.15900 0.021500 1.57e-01 8.78e-01 2.62e-01
Termination of translesion DNA synthesis 31 5.29e-01 6.87e-01 0.15800 0.114000 1.10e-01 2.71e-01 2.90e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 12 7.51e-01 8.39e-01 0.15800 -0.125000 -9.67e-02 4.53e-01 5.62e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 6.79e-01 7.86e-01 0.15800 0.137000 7.83e-02 4.30e-01 6.53e-01
Plasma lipoprotein assembly, remodeling, and clearance 73 2.21e-01 4.05e-01 0.15800 -0.116000 -1.07e-01 8.60e-02 1.13e-01
Activation of kainate receptors upon glutamate binding 29 2.15e-01 4.01e-01 0.15800 -0.147000 -5.89e-02 1.72e-01 5.83e-01
Diseases associated with glycosaminoglycan metabolism 38 3.20e-01 5.05e-01 0.15800 -0.133000 -8.51e-02 1.56e-01 3.64e-01
NPAS4 regulates expression of target genes 21 2.65e-01 4.52e-01 0.15800 -0.049300 -1.50e-01 6.96e-01 2.34e-01
Complement cascade 56 6.45e-02 1.94e-01 0.15800 -0.145000 -6.25e-02 6.09e-02 4.19e-01
Regulation of Complement cascade 45 9.84e-02 2.51e-01 0.15700 -0.146000 -5.98e-02 9.07e-02 4.88e-01
Signaling by PDGF 52 2.22e-01 4.05e-01 0.15700 -0.132000 -8.59e-02 1.00e-01 2.84e-01
Activation of NMDA receptors and postsynaptic events 69 5.70e-02 1.81e-01 0.15700 -0.141000 -6.96e-02 4.31e-02 3.17e-01
Prostacyclin signalling through prostacyclin receptor 19 1.80e-01 3.59e-01 0.15700 0.025800 1.54e-01 8.46e-01 2.44e-01
activated TAK1 mediates p38 MAPK activation 16 4.32e-01 6.10e-01 0.15600 0.057900 1.45e-01 6.88e-01 3.14e-01
PCNA-Dependent Long Patch Base Excision Repair 21 5.35e-01 6.92e-01 0.15600 0.132000 8.39e-02 2.95e-01 5.06e-01
RHOQ GTPase cycle 57 3.80e-02 1.38e-01 0.15500 -0.146000 -5.22e-02 5.57e-02 4.96e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 41 4.48e-01 6.29e-01 0.15500 0.110000 1.10e-01 2.24e-01 2.24e-01
Acetylcholine regulates insulin secretion 10 4.08e-01 5.88e-01 0.15500 0.024700 1.53e-01 8.93e-01 4.02e-01
Inhibition of DNA recombination at telomere 20 6.75e-01 7.84e-01 0.15500 0.112000 1.06e-01 3.85e-01 4.11e-01
Molecules associated with elastic fibres 29 4.85e-01 6.60e-01 0.15400 -0.126000 -8.91e-02 2.42e-01 4.06e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 29 4.86e-01 6.60e-01 0.15400 -0.125000 -8.90e-02 2.43e-01 4.07e-01
Trafficking of AMPA receptors 29 4.86e-01 6.60e-01 0.15400 -0.125000 -8.90e-02 2.43e-01 4.07e-01
Phase I - Functionalization of compounds 100 1.44e-01 3.16e-01 0.15400 -0.112000 -1.05e-01 5.31e-02 6.85e-02
Asparagine N-linked glycosylation 278 2.99e-03 2.28e-02 0.15400 0.097700 1.19e-01 5.03e-03 6.54e-04
PKA activation in glucagon signalling 17 1.24e-01 2.95e-01 0.15300 -0.153000 2.73e-03 2.73e-01 9.84e-01
MAPK3 (ERK1) activation 10 8.13e-01 8.71e-01 0.15300 -0.117000 -9.84e-02 5.20e-01 5.90e-01
ZBP1(DAI) mediated induction of type I IFNs 20 5.52e-01 7.03e-01 0.15300 0.080400 1.30e-01 5.34e-01 3.13e-01
RHO GTPases activate IQGAPs 11 2.32e-01 4.15e-01 0.15300 -0.153000 1.09e-02 3.80e-01 9.50e-01
Depolymerisation of the Nuclear Lamina 14 5.41e-01 6.95e-01 0.15300 0.062600 1.39e-01 6.85e-01 3.67e-01
Glycogen synthesis 13 1.40e-01 3.12e-01 0.15300 -0.026400 1.50e-01 8.69e-01 3.48e-01
Interleukin-10 signaling 45 3.66e-01 5.50e-01 0.15200 0.092500 1.21e-01 2.83e-01 1.60e-01
Uptake and function of anthrax toxins 11 1.54e-01 3.26e-01 0.15200 -0.146000 4.25e-02 4.01e-01 8.07e-01
Cell-extracellular matrix interactions 14 7.68e-01 8.41e-01 0.15200 -0.108000 -1.07e-01 4.84e-01 4.87e-01
Beta defensins 28 5.86e-01 7.29e-01 0.15200 -0.111000 -1.04e-01 3.08e-01 3.43e-01
Advanced glycosylation endproduct receptor signaling 13 2.77e-01 4.63e-01 0.15200 0.151000 1.42e-02 3.45e-01 9.29e-01
Signaling by FGFR1 49 1.40e-02 7.00e-02 0.15200 0.150000 2.32e-02 6.89e-02 7.79e-01
Mismatch Repair 15 2.79e-01 4.63e-01 0.15200 0.150000 2.48e-02 3.15e-01 8.68e-01
Activation of gene expression by SREBF (SREBP) 42 3.94e-01 5.76e-01 0.15100 0.090900 1.20e-01 3.08e-01 1.77e-01
Interleukin-12 family signaling 53 3.75e-01 5.55e-01 0.15100 0.105000 1.08e-01 1.84e-01 1.74e-01
Signaling by ALK 26 6.10e-01 7.45e-01 0.15100 -0.112000 -1.01e-01 3.23e-01 3.73e-01
Infectious disease 830 2.05e-07 1.34e-05 0.15100 0.099900 1.13e-01 9.32e-07 3.25e-08
Glycosphingolipid metabolism 40 4.51e-01 6.30e-01 0.14900 0.115000 9.51e-02 2.07e-01 2.98e-01
Telomere C-strand (Lagging Strand) Synthesis 32 5.46e-01 6.98e-01 0.14900 0.098100 1.12e-01 3.37e-01 2.72e-01
Inactivation of CSF3 (G-CSF) signaling 23 2.82e-01 4.67e-01 0.14900 0.047700 1.41e-01 6.92e-01 2.41e-01
Other semaphorin interactions 18 5.49e-01 7.01e-01 0.14900 -0.131000 -7.10e-02 3.36e-01 6.02e-01
Role of LAT2/NTAL/LAB on calcium mobilization 13 1.41e-01 3.12e-01 0.14900 -0.145000 3.12e-02 3.64e-01 8.45e-01
Synthesis of substrates in N-glycan biosythesis 60 3.38e-01 5.24e-01 0.14900 0.103000 1.08e-01 1.69e-01 1.49e-01
Signaling by FGFR1 in disease 37 5.14e-01 6.76e-01 0.14900 0.105000 1.05e-01 2.71e-01 2.67e-01
Nucleotide Excision Repair 107 7.86e-02 2.18e-01 0.14900 0.122000 8.48e-02 2.92e-02 1.29e-01
Gene Silencing by RNA 80 8.66e-02 2.30e-01 0.14800 0.073900 1.29e-01 2.53e-01 4.66e-02
Metallothioneins bind metals 11 1.47e-01 3.16e-01 0.14800 0.138000 -5.42e-02 4.28e-01 7.56e-01
Adrenaline,noradrenaline inhibits insulin secretion 28 3.70e-01 5.52e-01 0.14800 -0.132000 -6.74e-02 2.27e-01 5.37e-01
Dopamine Neurotransmitter Release Cycle 20 4.53e-01 6.31e-01 0.14800 -0.134000 -6.26e-02 2.99e-01 6.28e-01
Antigen processing: Ubiquitination & Proteasome degradation 293 1.32e-03 1.17e-02 0.14800 0.086100 1.20e-01 1.12e-02 3.84e-04
RAF-independent MAPK1/3 activation 22 6.45e-01 7.67e-01 0.14800 0.115000 9.29e-02 3.50e-01 4.51e-01
Downstream signaling of activated FGFR3 24 1.67e-01 3.44e-01 0.14800 0.145000 2.93e-02 2.19e-01 8.03e-01
O-linked glycosylation of mucins 62 4.71e-02 1.60e-01 0.14700 -0.138000 -5.15e-02 6.02e-02 4.83e-01
Regulation of TP53 Activity 154 6.48e-02 1.94e-01 0.14700 0.108000 9.92e-02 2.06e-02 3.35e-02
Synthesis of IP2, IP, and Ins in the cytosol 13 7.87e-01 8.54e-01 0.14600 -0.111000 -9.58e-02 4.89e-01 5.50e-01
Class I MHC mediated antigen processing & presentation 361 4.41e-04 4.64e-03 0.14600 0.086500 1.18e-01 4.72e-03 1.14e-04
Aquaporin-mediated transport 51 1.11e-01 2.70e-01 0.14600 -0.135000 -5.67e-02 9.60e-02 4.83e-01
PKA-mediated phosphorylation of CREB 19 2.05e-01 3.89e-01 0.14600 -0.145000 -2.01e-02 2.75e-01 8.79e-01
Pyruvate metabolism 29 1.25e-01 2.95e-01 0.14600 0.143000 2.93e-02 1.84e-01 7.84e-01
Post-translational protein phosphorylation 100 1.09e-01 2.67e-01 0.14500 -0.118000 -8.41e-02 4.06e-02 1.46e-01
Neurotransmitter release cycle 47 3.88e-01 5.69e-01 0.14500 -0.115000 -8.83e-02 1.73e-01 2.95e-01
RNA Polymerase I Transcription Termination 27 3.91e-01 5.73e-01 0.14300 0.129000 6.36e-02 2.47e-01 5.68e-01
Cytochrome P450 - arranged by substrate type 64 3.14e-01 5.01e-01 0.14300 -0.110000 -9.09e-02 1.28e-01 2.08e-01
Glyoxylate metabolism and glycine degradation 30 5.90e-01 7.33e-01 0.14200 0.108000 9.22e-02 3.04e-01 3.82e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 29 6.22e-01 7.54e-01 0.14200 -0.100000 -1.00e-01 3.49e-01 3.50e-01
Transcriptional regulation by RUNX2 116 1.49e-01 3.19e-01 0.14200 0.097200 1.03e-01 7.04e-02 5.54e-02
MET activates RAP1 and RAC1 11 6.63e-01 7.77e-01 0.14100 0.058000 1.29e-01 7.39e-01 4.60e-01
Peroxisomal protein import 62 2.26e-01 4.08e-01 0.14100 0.119000 7.59e-02 1.06e-01 3.01e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 5.79e-01 7.25e-01 0.14100 0.116000 7.94e-02 3.15e-01 4.92e-01
G-protein activation 24 3.49e-01 5.34e-01 0.14000 0.050200 1.31e-01 6.70e-01 2.66e-01
Downstream TCR signaling 92 2.29e-01 4.12e-01 0.14000 0.099600 9.89e-02 9.86e-02 1.01e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 2.39e-01 4.22e-01 0.14000 -0.026500 1.37e-01 8.79e-01 4.30e-01
Prolactin receptor signaling 15 3.10e-01 4.96e-01 0.14000 0.017700 1.39e-01 9.06e-01 3.52e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 7.68e-01 8.41e-01 0.13900 -0.108000 -8.77e-02 4.68e-01 5.56e-01
Attachment and Entry 9694614 16 3.08e-01 4.96e-01 0.13900 -0.137000 -2.06e-02 3.41e-01 8.86e-01
Signaling by high-kinase activity BRAF mutants 32 2.74e-01 4.62e-01 0.13900 0.052400 1.29e-01 6.08e-01 2.07e-01
Endosomal/Vacuolar pathway 12 1.64e-01 3.40e-01 0.13900 0.047700 -1.31e-01 7.75e-01 4.34e-01
Germ layer formation at gastrulation 16 7.07e-01 8.08e-01 0.13900 -0.077700 -1.15e-01 5.91e-01 4.25e-01
Nonhomologous End-Joining (NHEJ) 32 4.94e-01 6.61e-01 0.13800 0.076100 1.15e-01 4.56e-01 2.59e-01
STING mediated induction of host immune responses 13 7.62e-01 8.39e-01 0.13800 0.078200 1.14e-01 6.26e-01 4.78e-01
RHOD GTPase cycle 48 2.62e-01 4.49e-01 0.13800 -0.121000 -6.67e-02 1.47e-01 4.24e-01
ALK mutants bind TKIs 12 1.29e-01 3.00e-01 0.13700 -0.113000 7.85e-02 5.00e-01 6.38e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 8.45e-01 8.97e-01 0.13600 -0.098600 -9.43e-02 5.71e-01 5.88e-01
Negative regulation of FLT3 15 6.68e-01 7.82e-01 0.13600 0.119000 6.65e-02 4.25e-01 6.56e-01
RND1 GTPase cycle 41 1.92e-01 3.74e-01 0.13600 -0.127000 -4.95e-02 1.61e-01 5.83e-01
Regulation of TP53 Activity through Acetylation 29 5.93e-01 7.34e-01 0.13600 0.108000 8.19e-02 3.12e-01 4.45e-01
Transmission across Chemical Synapses 237 6.01e-03 3.76e-02 0.13600 -0.114000 -7.38e-02 2.54e-03 5.02e-02
Organic cation transport 10 8.11e-01 8.70e-01 0.13500 0.075000 1.13e-01 6.81e-01 5.37e-01
Heme signaling 45 9.91e-02 2.52e-01 0.13500 -0.130000 -3.71e-02 1.32e-01 6.67e-01
Dermatan sulfate biosynthesis 10 6.22e-01 7.54e-01 0.13500 -0.129000 -4.10e-02 4.81e-01 8.23e-01
Interleukin-2 signaling 11 6.56e-01 7.75e-01 0.13500 -0.125000 -5.06e-02 4.73e-01 7.71e-01
Plasma lipoprotein assembly 19 7.13e-01 8.11e-01 0.13500 -0.108000 -8.12e-02 4.17e-01 5.40e-01
Signaling by NTRKs 133 1.42e-01 3.13e-01 0.13400 0.096500 9.35e-02 5.46e-02 6.25e-02
Incretin synthesis, secretion, and inactivation 23 5.17e-01 6.79e-01 0.13400 0.061700 1.19e-01 6.08e-01 3.22e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 25 5.12e-01 6.75e-01 0.13400 0.064300 1.18e-01 5.78e-01 3.08e-01
Phospholipase C-mediated cascade; FGFR4 14 9.62e-02 2.47e-01 0.13400 0.092200 -9.74e-02 5.50e-01 5.28e-01
Apoptosis 164 1.53e-02 7.35e-02 0.13400 0.065600 1.17e-01 1.47e-01 9.92e-03
Signaling by EGFR 49 2.26e-01 4.08e-01 0.13400 0.058700 1.20e-01 4.77e-01 1.46e-01
GPCR downstream signalling 603 4.10e-06 1.36e-04 0.13300 -0.112000 -7.26e-02 2.57e-06 2.28e-03
GRB2 events in EGFR signaling 13 6.93e-01 7.99e-01 0.13300 0.060900 1.18e-01 7.04e-01 4.61e-01
SARS-CoV-2 Infection 276 1.48e-02 7.28e-02 0.13300 0.085700 1.01e-01 1.42e-02 3.71e-03
Regulation of RUNX1 Expression and Activity 25 6.71e-01 7.84e-01 0.13300 0.083700 1.03e-01 4.69e-01 3.73e-01
Presynaptic phase of homologous DNA pairing and strand exchange 38 4.94e-01 6.61e-01 0.13200 0.076300 1.08e-01 4.16e-01 2.49e-01
Phospholipase C-mediated cascade; FGFR2 17 6.30e-02 1.93e-01 0.13200 0.096800 -9.02e-02 4.90e-01 5.19e-01
RHOJ GTPase cycle 51 1.10e-01 2.69e-01 0.13200 -0.125000 -4.23e-02 1.22e-01 6.01e-01
Beta-oxidation of very long chain fatty acids 10 5.99e-01 7.36e-01 0.13200 0.127000 3.39e-02 4.85e-01 8.53e-01
PIP3 activates AKT signaling 275 2.18e-02 9.39e-02 0.13100 0.092600 9.30e-02 8.15e-03 7.87e-03
Pyrimidine catabolism 12 2.00e-01 3.82e-01 0.13100 -0.123000 4.53e-02 4.61e-01 7.86e-01
ADP signalling through P2Y purinoceptor 12 22 1.83e-01 3.61e-01 0.13100 0.008590 1.31e-01 9.44e-01 2.89e-01
FRS-mediated FGFR4 signaling 21 2.50e-01 4.33e-01 0.13100 0.130000 1.87e-02 3.04e-01 8.82e-01
Interleukin-1 family signaling 145 9.88e-02 2.52e-01 0.13100 0.080600 1.03e-01 9.37e-02 3.23e-02
Amino acid transport across the plasma membrane 30 4.88e-01 6.60e-01 0.13100 -0.113000 -6.47e-02 2.83e-01 5.40e-01
Transcriptional Regulation by NPAS4 33 5.68e-01 7.17e-01 0.13000 -0.077200 -1.05e-01 4.43e-01 2.96e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 2.23e-01 4.06e-01 0.13000 0.109000 7.15e-02 1.01e-01 2.81e-01
SUMOylation of transcription cofactors 43 5.41e-01 6.95e-01 0.13000 0.097200 8.65e-02 2.70e-01 3.26e-01
Extension of Telomeres 48 5.13e-01 6.75e-01 0.13000 0.089500 9.45e-02 2.83e-01 2.57e-01
mRNA Capping 28 5.49e-01 7.01e-01 0.13000 0.067800 1.10e-01 5.34e-01 3.12e-01
tRNA modification in the nucleus and cytosol 38 5.80e-01 7.25e-01 0.12900 0.097700 8.48e-02 2.97e-01 3.66e-01
Anti-inflammatory response favouring Leishmania parasite infection 75 3.21e-02 1.21e-01 0.12900 -0.124000 -3.66e-02 6.35e-02 5.84e-01
Leishmania parasite growth and survival 75 3.21e-02 1.21e-01 0.12900 -0.124000 -3.66e-02 6.35e-02 5.84e-01
Amino acids regulate mTORC1 52 4.09e-01 5.88e-01 0.12900 0.105000 7.55e-02 1.91e-01 3.46e-01
Glucagon signaling in metabolic regulation 33 4.51e-02 1.56e-01 0.12900 -0.009460 1.28e-01 9.25e-01 2.02e-01
FRS-mediated FGFR2 signaling 24 1.72e-01 3.50e-01 0.12800 0.128000 9.29e-03 2.77e-01 9.37e-01
RHOU GTPase cycle 37 2.11e-01 3.97e-01 0.12800 -0.122000 -3.98e-02 1.99e-01 6.75e-01
Diseases of glycosylation 137 2.30e-02 9.73e-02 0.12800 -0.115000 -5.69e-02 2.02e-02 2.50e-01
RA biosynthesis pathway 22 6.86e-01 7.92e-01 0.12800 0.104000 7.44e-02 3.98e-01 5.46e-01
RAC1 GTPase cycle 170 3.61e-06 1.27e-04 0.12800 -0.128000 -7.93e-03 4.07e-03 8.58e-01
Gastrin-CREB signalling pathway via PKC and MAPK 17 6.76e-01 7.84e-01 0.12700 -0.062900 -1.11e-01 6.54e-01 4.29e-01
HATs acetylate histones 71 2.99e-01 4.85e-01 0.12700 0.073800 1.04e-01 2.82e-01 1.30e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 23 5.37e-01 6.92e-01 0.12700 0.056900 1.14e-01 6.37e-01 3.44e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 23 5.37e-01 6.92e-01 0.12700 0.056900 1.14e-01 6.37e-01 3.44e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 23 5.37e-01 6.92e-01 0.12700 0.056900 1.14e-01 6.37e-01 3.44e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 23 5.37e-01 6.92e-01 0.12700 0.056900 1.14e-01 6.37e-01 3.44e-01
Impaired BRCA2 binding to PALB2 23 5.37e-01 6.92e-01 0.12700 0.056900 1.14e-01 6.37e-01 3.44e-01
Translesion synthesis by POLI 17 6.46e-01 7.67e-01 0.12700 0.058500 1.13e-01 6.76e-01 4.20e-01
RHO GTPases Activate WASPs and WAVEs 34 5.56e-01 7.06e-01 0.12700 0.104000 7.28e-02 2.94e-01 4.62e-01
Vitamin D (calciferol) metabolism 12 7.42e-01 8.33e-01 0.12700 -0.059300 -1.12e-01 7.22e-01 5.02e-01
Biotin transport and metabolism 10 3.15e-01 5.01e-01 0.12700 -0.033300 1.22e-01 8.55e-01 5.04e-01
Rab regulation of trafficking 113 6.69e-02 1.97e-01 0.12700 0.111000 6.04e-02 4.10e-02 2.67e-01
Regulation of PLK1 Activity at G2/M Transition 83 1.38e-01 3.08e-01 0.12600 0.060300 1.11e-01 3.42e-01 8.03e-02
G alpha (i) signalling events 305 1.87e-03 1.56e-02 0.12600 -0.108000 -6.50e-02 1.16e-03 5.07e-02
Opioid Signalling 88 3.27e-03 2.45e-02 0.12600 -0.125000 -1.40e-02 4.25e-02 8.20e-01
Listeria monocytogenes entry into host cells 19 5.64e-01 7.13e-01 0.12600 0.051100 1.15e-01 7.00e-01 3.86e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 6.95e-01 7.99e-01 0.12600 0.050600 1.15e-01 7.61e-01 4.91e-01
RNA Polymerase I Promoter Escape 28 3.90e-01 5.71e-01 0.12500 0.117000 4.65e-02 2.86e-01 6.70e-01
G beta:gamma signalling through BTK 17 2.37e-01 4.20e-01 0.12500 -0.005110 1.25e-01 9.71e-01 3.72e-01
RHOG GTPase cycle 69 3.40e-02 1.27e-01 0.12500 -0.122000 -2.89e-02 8.08e-02 6.78e-01
Platelet calcium homeostasis 27 7.09e-01 8.08e-01 0.12500 -0.089700 -8.68e-02 4.20e-01 4.35e-01
Apoptotic execution phase 43 3.21e-02 1.21e-01 0.12500 -0.001220 1.25e-01 9.89e-01 1.57e-01
Interleukin-7 signaling 21 7.14e-01 8.11e-01 0.12500 -0.101000 -7.29e-02 4.22e-01 5.63e-01
G beta:gamma signalling through CDC42 19 1.99e-01 3.82e-01 0.12500 -0.006130 1.24e-01 9.63e-01 3.48e-01
LGI-ADAM interactions 14 4.87e-01 6.60e-01 0.12400 0.122000 2.62e-02 4.31e-01 8.65e-01
Innate Immune System 999 6.11e-06 1.69e-04 0.12400 0.087400 8.77e-02 2.71e-06 2.53e-06
Tandem pore domain potassium channels 12 6.83e-01 7.90e-01 0.12400 -0.047000 -1.14e-01 7.78e-01 4.92e-01
LDL clearance 19 7.87e-01 8.54e-01 0.12300 -0.083800 -9.07e-02 5.27e-01 4.94e-01
Notch-HLH transcription pathway 24 1.86e-01 3.66e-01 0.12300 0.006380 1.23e-01 9.57e-01 2.97e-01
Resolution of Sister Chromatid Cohesion 98 2.45e-01 4.27e-01 0.12200 0.074200 9.71e-02 2.04e-01 9.64e-02
RHOH GTPase cycle 36 6.15e-01 7.47e-01 0.12200 0.077100 9.49e-02 4.23e-01 3.25e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 54 3.51e-01 5.34e-01 0.12200 0.063100 1.04e-01 4.22e-01 1.84e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 54 3.51e-01 5.34e-01 0.12200 0.063100 1.04e-01 4.22e-01 1.84e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 54 3.51e-01 5.34e-01 0.12200 0.063100 1.04e-01 4.22e-01 1.84e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 54 3.51e-01 5.34e-01 0.12200 0.063100 1.04e-01 4.22e-01 1.84e-01
Signaling by NOTCH1 in Cancer 54 3.51e-01 5.34e-01 0.12200 0.063100 1.04e-01 4.22e-01 1.84e-01
FGFR2 alternative splicing 26 7.28e-01 8.22e-01 0.12200 0.083400 8.87e-02 4.62e-01 4.34e-01
G alpha (12/13) signalling events 74 2.45e-02 1.00e-01 0.12100 -0.119000 -2.42e-02 7.66e-02 7.19e-01
SUMOylation of DNA methylation proteins 16 4.13e-01 5.92e-01 0.12100 0.120000 1.89e-02 4.07e-01 8.96e-01
Glucose metabolism 87 3.41e-01 5.27e-01 0.12100 0.080500 9.06e-02 1.94e-01 1.44e-01
Regulation of beta-cell development 41 5.85e-01 7.29e-01 0.12100 0.093400 7.69e-02 3.01e-01 3.94e-01
Homologous DNA Pairing and Strand Exchange 41 5.18e-01 6.79e-01 0.12100 0.068200 9.96e-02 4.49e-01 2.70e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 32 9.37e-02 2.42e-01 0.12000 0.120000 -7.11e-04 2.39e-01 9.94e-01
Fc epsilon receptor (FCERI) signaling 126 1.37e-01 3.07e-01 0.12000 0.068000 9.90e-02 1.87e-01 5.48e-02
Mitotic Prometaphase 174 5.38e-02 1.75e-01 0.11900 0.064900 1.00e-01 1.39e-01 2.25e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 6.72e-01 7.84e-01 0.11900 -0.112000 -4.09e-02 5.01e-01 8.06e-01
VEGFR2 mediated vascular permeability 26 3.71e-02 1.36e-01 0.11900 -0.100000 6.46e-02 3.77e-01 5.69e-01
Downregulation of ERBB2 signaling 28 1.44e-01 3.16e-01 0.11900 0.002420 1.19e-01 9.82e-01 2.75e-01
Regulation of NF-kappa B signaling 17 7.61e-01 8.39e-01 0.11900 0.098800 6.61e-02 4.81e-01 6.37e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 8.55e-01 9.02e-01 0.11900 0.073600 9.29e-02 6.59e-01 5.77e-01
alpha-linolenic acid (ALA) metabolism 12 8.55e-01 9.02e-01 0.11900 0.073600 9.29e-02 6.59e-01 5.77e-01
Vitamin B5 (pantothenate) metabolism 16 7.06e-01 8.08e-01 0.11800 0.055400 1.05e-01 7.01e-01 4.69e-01
Metabolism of amino acids and derivatives 344 2.04e-02 8.98e-02 0.11800 0.085200 8.22e-02 6.58e-03 8.75e-03
Neurotransmitter receptors and postsynaptic signal transmission 175 2.60e-02 1.04e-01 0.11800 -0.104000 -5.65e-02 1.76e-02 1.97e-01
N-Glycan antennae elongation 15 7.31e-01 8.25e-01 0.11800 0.056100 1.04e-01 7.07e-01 4.87e-01
Purine catabolism 17 5.11e-01 6.75e-01 0.11700 0.113000 3.15e-02 4.19e-01 8.22e-01
Activated point mutants of FGFR2 16 1.33e-01 3.04e-01 0.11700 0.091900 -7.25e-02 5.24e-01 6.15e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 8.07e-01 8.70e-01 0.11700 0.085700 7.93e-02 5.18e-01 5.49e-01
PI-3K cascade:FGFR1 21 7.05e-02 2.03e-01 0.11700 0.088300 -7.65e-02 4.84e-01 5.44e-01
Signaling by NOTCH 182 1.06e-01 2.64e-01 0.11700 0.073300 9.08e-02 8.78e-02 3.46e-02
PKMTs methylate histone lysines 37 1.04e-02 5.62e-02 0.11700 -0.094500 6.83e-02 3.20e-01 4.72e-01
G beta:gamma signalling through PI3Kgamma 25 2.60e-01 4.47e-01 0.11600 0.014900 1.15e-01 8.97e-01 3.18e-01
ABC-family proteins mediated transport 98 2.86e-01 4.72e-01 0.11600 0.071400 9.19e-02 2.22e-01 1.16e-01
Regulation of lipid metabolism by PPARalpha 116 5.13e-03 3.37e-02 0.11600 0.023500 1.14e-01 6.62e-01 3.41e-02
Physiological factors 14 7.41e-01 8.32e-01 0.11600 -0.103000 -5.34e-02 5.04e-01 7.30e-01
Telomere Maintenance 62 4.93e-01 6.61e-01 0.11600 0.087100 7.66e-02 2.35e-01 2.97e-01
Signalling to ERKs 34 6.38e-01 7.64e-01 0.11600 0.092700 6.95e-02 3.49e-01 4.83e-01
Synthesis of PC 27 6.73e-01 7.84e-01 0.11600 0.065700 9.54e-02 5.55e-01 3.91e-01
Diseases of signal transduction by growth factor receptors and second messengers 410 9.28e-04 9.08e-03 0.11500 0.059300 9.85e-02 3.91e-02 6.11e-04
FGFR4 ligand binding and activation 13 2.04e-01 3.89e-01 0.11500 0.085800 -7.62e-02 5.92e-01 6.34e-01
PPARA activates gene expression 114 4.06e-03 2.85e-02 0.11500 0.018900 1.13e-01 7.27e-01 3.67e-02
RUNX2 regulates bone development 29 7.09e-01 8.08e-01 0.11500 -0.072600 -8.89e-02 4.99e-01 4.07e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 8.98e-01 9.31e-01 0.11500 0.081200 8.09e-02 6.57e-01 6.58e-01
RNA Pol II CTD phosphorylation and interaction with CE 26 5.94e-01 7.34e-01 0.11400 0.053700 1.01e-01 6.35e-01 3.73e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 26 5.94e-01 7.34e-01 0.11400 0.053700 1.01e-01 6.35e-01 3.73e-01
CDC42 GTPase cycle 143 2.82e-03 2.17e-02 0.11400 -0.111000 -2.59e-02 2.20e-02 5.93e-01
Phenylalanine and tyrosine metabolism 10 4.64e-01 6.43e-01 0.11300 -0.012000 1.13e-01 9.47e-01 5.37e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 39 5.55e-01 7.05e-01 0.11300 0.062000 9.50e-02 5.03e-01 3.04e-01
Diseases of DNA Double-Strand Break Repair 39 5.55e-01 7.05e-01 0.11300 0.062000 9.50e-02 5.03e-01 3.04e-01
SHC1 events in ERBB4 signaling 14 8.11e-01 8.70e-01 0.11200 0.061300 9.43e-02 6.91e-01 5.41e-01
Zinc transporters 17 1.45e-01 3.16e-01 0.11200 0.092800 -6.32e-02 5.08e-01 6.52e-01
Retrograde transport at the Trans-Golgi-Network 47 4.21e-01 5.98e-01 0.11200 0.054200 9.81e-02 5.20e-01 2.44e-01
Meiotic synapsis 32 3.80e-01 5.58e-01 0.11200 0.037100 1.06e-01 7.17e-01 3.00e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 2.17e-01 4.03e-01 0.11200 0.105000 3.81e-02 1.89e-01 6.35e-01
Metabolism of steroids 148 2.90e-02 1.13e-01 0.11200 -0.102000 -4.52e-02 3.15e-02 3.42e-01
EGFR downregulation 30 2.77e-01 4.63e-01 0.11200 0.022000 1.10e-01 8.34e-01 2.99e-01
SLBP independent Processing of Histone Pre-mRNAs 10 7.56e-01 8.39e-01 0.11200 0.104000 3.96e-02 5.67e-01 8.28e-01
Interferon Signaling 191 4.69e-02 1.60e-01 0.11200 0.095400 5.78e-02 2.29e-02 1.68e-01
Citric acid cycle (TCA cycle) 21 7.92e-01 8.57e-01 0.11100 0.086100 7.07e-02 4.95e-01 5.75e-01
Downstream signaling of activated FGFR1 31 4.77e-02 1.62e-01 0.11100 0.103000 -4.15e-02 3.22e-01 6.89e-01
mRNA Editing 10 8.43e-01 8.95e-01 0.11100 -0.055100 -9.60e-02 7.63e-01 5.99e-01
Regulation of TP53 Degradation 36 5.54e-01 7.05e-01 0.11000 0.056100 9.52e-02 5.60e-01 3.23e-01
Estrogen-dependent gene expression 91 2.68e-01 4.56e-01 0.11000 0.060000 9.28e-02 3.22e-01 1.26e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 5.61e-01 7.11e-01 0.11000 -0.030700 -1.06e-01 8.26e-01 4.49e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 89 3.71e-01 5.52e-01 0.10900 0.067100 8.58e-02 2.74e-01 1.61e-01
Amplification of signal from the kinetochores 89 3.71e-01 5.52e-01 0.10900 0.067100 8.58e-02 2.74e-01 1.61e-01
HSF1-dependent transactivation 35 3.48e-01 5.34e-01 0.10900 0.104000 3.40e-02 2.89e-01 7.28e-01
Acetylcholine binding and downstream events 14 2.51e-01 4.35e-01 0.10900 0.098300 -4.65e-02 5.24e-01 7.63e-01
Postsynaptic nicotinic acetylcholine receptors 14 2.51e-01 4.35e-01 0.10900 0.098300 -4.65e-02 5.24e-01 7.63e-01
Post-chaperonin tubulin folding pathway 23 7.57e-01 8.39e-01 0.10800 0.087900 6.33e-02 4.66e-01 5.99e-01
Signaling by the B Cell Receptor (BCR) 105 2.95e-01 4.81e-01 0.10800 0.064300 8.68e-02 2.55e-01 1.24e-01
Signaling by ERBB2 ECD mutants 15 7.08e-01 8.08e-01 0.10700 0.041500 9.83e-02 7.81e-01 5.10e-01
p130Cas linkage to MAPK signaling for integrins 15 5.01e-01 6.68e-01 0.10600 -0.106000 -1.23e-02 4.79e-01 9.34e-01
Activation of AMPK downstream of NMDARs 10 8.11e-01 8.70e-01 0.10600 0.096700 4.39e-02 5.97e-01 8.10e-01
NR1H2 and NR1H3-mediated signaling 53 5.93e-01 7.34e-01 0.10600 -0.081100 -6.80e-02 3.07e-01 3.92e-01
Synthesis, secretion, and deacylation of Ghrelin 19 6.13e-01 7.47e-01 0.10600 0.036700 9.93e-02 7.82e-01 4.54e-01
Reproduction 82 1.03e-01 2.59e-01 0.10600 -0.100000 -3.36e-02 1.17e-01 5.98e-01
TGF-beta receptor signaling activates SMADs 45 6.61e-01 7.77e-01 0.10500 -0.077500 -7.13e-02 3.68e-01 4.08e-01
MASTL Facilitates Mitotic Progression 10 8.68e-01 9.10e-01 0.10500 0.055100 8.97e-02 7.63e-01 6.23e-01
Apoptotic cleavage of cellular proteins 35 4.67e-02 1.60e-01 0.10500 -0.037800 9.82e-02 6.99e-01 3.14e-01
Signaling by GPCR 670 3.95e-04 4.38e-03 0.10500 -0.086300 -5.96e-02 1.34e-04 8.38e-03
p75 NTR receptor-mediated signalling 89 1.01e-01 2.55e-01 0.10500 -0.098600 -3.55e-02 1.08e-01 5.62e-01
AURKA Activation by TPX2 68 3.70e-01 5.52e-01 0.10500 0.053400 9.01e-02 4.47e-01 1.99e-01
TCF dependent signaling in response to WNT 168 2.27e-01 4.10e-01 0.10300 0.076500 6.84e-02 8.68e-02 1.26e-01
Leading Strand Synthesis 13 8.38e-01 8.91e-01 0.10200 0.087600 5.33e-02 5.85e-01 7.39e-01
Polymerase switching 13 8.38e-01 8.91e-01 0.10200 0.087600 5.33e-02 5.85e-01 7.39e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 3.20e-01 5.05e-01 0.10200 0.096200 -3.47e-02 5.33e-01 8.22e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 3.46e-01 5.32e-01 0.10200 -0.099600 -1.99e-02 3.45e-01 8.51e-01
FGFR2 ligand binding and activation 19 2.31e-01 4.14e-01 0.10200 0.096900 -3.04e-02 4.65e-01 8.19e-01
Sulfur amino acid metabolism 27 7.41e-01 8.32e-01 0.10100 0.058000 8.32e-02 6.02e-01 4.54e-01
GABA receptor activation 57 1.15e-01 2.78e-01 0.10100 -0.100000 -1.66e-02 1.91e-01 8.28e-01
Disease 1567 1.72e-07 1.27e-05 0.10100 0.059300 8.21e-02 8.11e-05 4.84e-08
Signal attenuation 10 6.72e-01 7.84e-01 0.10100 -0.014100 -1.00e-01 9.38e-01 5.84e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 7.39e-01 8.31e-01 0.10100 0.046600 8.92e-02 7.25e-01 5.01e-01
RET signaling 41 6.29e-01 7.59e-01 0.10100 -0.056400 -8.34e-02 5.32e-01 3.56e-01
Signaling by Hedgehog 133 2.62e-01 4.49e-01 0.10000 0.059500 8.08e-02 2.36e-01 1.07e-01
Chromatin modifying enzymes 186 4.03e-02 1.44e-01 0.10000 0.043600 9.02e-02 3.04e-01 3.38e-02
Chromatin organization 186 4.03e-02 1.44e-01 0.10000 0.043600 9.02e-02 3.04e-01 3.38e-02
CD28 dependent PI3K/Akt signaling 22 1.29e-01 3.00e-01 0.10000 -0.067600 7.38e-02 5.83e-01 5.49e-01
Interleukin-15 signaling 13 5.31e-01 6.89e-01 0.10000 0.002380 1.00e-01 9.88e-01 5.32e-01
Recruitment of NuMA to mitotic centrosomes 75 1.68e-01 3.46e-01 0.10000 0.033500 9.42e-02 6.16e-01 1.58e-01
mRNA decay by 3’ to 5’ exoribonuclease 16 8.72e-01 9.11e-01 0.09990 -0.065400 -7.55e-02 6.51e-01 6.01e-01
APC truncation mutants have impaired AXIN binding 13 7.62e-01 8.39e-01 0.09930 0.037000 9.21e-02 8.17e-01 5.65e-01
AXIN missense mutants destabilize the destruction complex 13 7.62e-01 8.39e-01 0.09930 0.037000 9.21e-02 8.17e-01 5.65e-01
Signaling by AMER1 mutants 13 7.62e-01 8.39e-01 0.09930 0.037000 9.21e-02 8.17e-01 5.65e-01
Signaling by APC mutants 13 7.62e-01 8.39e-01 0.09930 0.037000 9.21e-02 8.17e-01 5.65e-01
Signaling by AXIN mutants 13 7.62e-01 8.39e-01 0.09930 0.037000 9.21e-02 8.17e-01 5.65e-01
Truncations of AMER1 destabilize the destruction complex 13 7.62e-01 8.39e-01 0.09930 0.037000 9.21e-02 8.17e-01 5.65e-01
Regulation of TP53 Expression and Degradation 37 6.34e-01 7.61e-01 0.09900 0.052200 8.42e-02 5.83e-01 3.76e-01
EML4 and NUDC in mitotic spindle formation 93 3.66e-01 5.50e-01 0.09890 0.055700 8.17e-02 3.53e-01 1.73e-01
Glutamate Neurotransmitter Release Cycle 23 8.11e-01 8.70e-01 0.09880 -0.077700 -6.11e-02 5.19e-01 6.12e-01
Interleukin receptor SHC signaling 24 6.72e-01 7.84e-01 0.09880 -0.088700 -4.37e-02 4.52e-01 7.11e-01
Cell death signalling via NRAGE, NRIF and NADE 69 3.00e-01 4.86e-01 0.09860 -0.089300 -4.19e-02 1.99e-01 5.48e-01
Hedgehog ‘off’ state 97 3.38e-01 5.24e-01 0.09840 0.054100 8.21e-02 3.57e-01 1.62e-01
Processive synthesis on the C-strand of the telomere 19 8.58e-01 9.03e-01 0.09810 0.073000 6.55e-02 5.82e-01 6.21e-01
RHOC GTPase cycle 69 3.62e-02 1.33e-01 0.09790 -0.097900 -4.06e-04 1.59e-01 9.95e-01
Diseases of metabolism 234 5.78e-02 1.81e-01 0.09770 -0.083500 -5.09e-02 2.77e-02 1.80e-01
Presynaptic function of Kainate receptors 21 2.08e-01 3.93e-01 0.09770 -0.091500 3.41e-02 4.68e-01 7.87e-01
Mitochondrial Fatty Acid Beta-Oxidation 35 7.62e-01 8.39e-01 0.09760 0.070100 6.79e-02 4.73e-01 4.87e-01
Costimulation by the CD28 family 65 5.02e-01 6.68e-01 0.09710 -0.080600 -5.42e-02 2.61e-01 4.50e-01
G beta:gamma signalling through PLC beta 20 1.77e-01 3.55e-01 0.09660 -0.063800 7.25e-02 6.21e-01 5.74e-01
BBSome-mediated cargo-targeting to cilium 23 6.84e-01 7.90e-01 0.09640 0.087100 4.13e-02 4.69e-01 7.32e-01
Removal of the Flap Intermediate from the C-strand 17 8.70e-01 9.10e-01 0.09640 0.061700 7.40e-02 6.59e-01 5.97e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 42 4.02e-02 1.44e-01 0.09580 -0.041100 8.65e-02 6.45e-01 3.32e-01
Synthesis of PIPs at the early endosome membrane 15 4.36e-01 6.15e-01 0.09560 -0.094900 1.12e-02 5.24e-01 9.40e-01
DARPP-32 events 24 1.49e-01 3.19e-01 0.09500 -0.048800 8.15e-02 6.79e-01 4.89e-01
Prefoldin mediated transfer of substrate to CCT/TriC 27 1.04e-01 2.60e-01 0.09500 0.067600 -6.68e-02 5.43e-01 5.48e-01
Iron uptake and transport 57 2.38e-01 4.20e-01 0.09490 0.091200 2.63e-02 2.33e-01 7.31e-01
Downstream signaling of activated FGFR2 29 2.56e-01 4.42e-01 0.09470 0.094700 -2.10e-03 3.78e-01 9.84e-01
Cellular hexose transport 21 8.54e-01 9.02e-01 0.09460 -0.063000 -7.05e-02 6.17e-01 5.76e-01
Vasopressin regulates renal water homeostasis via Aquaporins 42 1.59e-01 3.33e-01 0.09430 -0.094200 -1.42e-03 2.90e-01 9.87e-01
Elastic fibre formation 40 5.79e-01 7.25e-01 0.09380 -0.083000 -4.38e-02 3.64e-01 6.31e-01
RHOBTB GTPase Cycle 34 4.26e-01 6.03e-01 0.09380 0.025300 9.03e-02 7.99e-01 3.62e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 6.57e-01 7.75e-01 0.09360 0.046300 8.13e-02 6.41e-01 4.12e-01
Semaphorin interactions 61 3.75e-01 5.55e-01 0.09350 -0.085000 -3.90e-02 2.51e-01 5.99e-01
Signaling by FGFR3 in disease 21 1.89e-01 3.69e-01 0.09340 0.075500 -5.50e-02 5.49e-01 6.63e-01
Mucopolysaccharidoses 10 9.25e-01 9.46e-01 0.09290 -0.058900 -7.18e-02 7.47e-01 6.94e-01
Signaling by Interleukins 434 3.11e-02 1.19e-01 0.09270 0.056900 7.32e-02 4.18e-02 8.83e-03
Signaling by ERBB2 49 1.15e-01 2.78e-01 0.09220 -0.001570 9.22e-02 9.85e-01 2.64e-01
Downstream signaling of activated FGFR4 26 3.57e-01 5.41e-01 0.09200 0.091900 4.19e-03 4.17e-01 9.70e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 15 5.49e-01 7.01e-01 0.09200 0.003580 9.19e-02 9.81e-01 5.38e-01
Sphingolipid de novo biosynthesis 41 7.17e-01 8.13e-01 0.09180 -0.072900 -5.57e-02 4.19e-01 5.37e-01
RHOA GTPase cycle 140 4.16e-03 2.91e-02 0.09170 -0.091600 -4.14e-03 6.11e-02 9.33e-01
Folding of actin by CCT/TriC 10 4.64e-01 6.43e-01 0.09170 0.073400 -5.50e-02 6.88e-01 7.63e-01
C-type lectin receptors (CLRs) 137 3.69e-01 5.52e-01 0.09160 0.059300 6.98e-02 2.31e-01 1.58e-01
IRF3-mediated induction of type I IFN 11 7.96e-01 8.61e-01 0.09150 0.029400 8.67e-02 8.66e-01 6.19e-01
Uptake and actions of bacterial toxins 29 2.72e-01 4.62e-01 0.09140 -0.091400 3.38e-03 3.94e-01 9.75e-01
Transcriptional regulation by RUNX1 183 2.37e-01 4.19e-01 0.09130 0.055800 7.22e-02 1.92e-01 9.18e-02
Signaling by FGFR2 IIIa TM 19 8.21e-01 8.78e-01 0.09120 0.048200 7.74e-02 7.16e-01 5.59e-01
Gastrulation 21 8.30e-01 8.85e-01 0.09120 -0.052500 -7.46e-02 6.77e-01 5.54e-01
Cytokine Signaling in Immune system 670 1.23e-02 6.41e-02 0.09080 0.063100 6.52e-02 5.24e-03 3.90e-03
Signaling by PDGFR in disease 20 3.70e-01 5.52e-01 0.09060 -0.010800 9.00e-02 9.33e-01 4.86e-01
Myogenesis 29 2.07e-01 3.92e-01 0.09040 -0.088700 1.73e-02 4.08e-01 8.72e-01
Syndecan interactions 19 5.98e-01 7.36e-01 0.08980 -0.087900 -1.85e-02 5.07e-01 8.89e-01
Biological oxidations 213 2.40e-01 4.22e-01 0.08970 -0.059900 -6.67e-02 1.32e-01 9.29e-02
Dual incision in TC-NER 63 5.97e-01 7.36e-01 0.08950 0.072500 5.26e-02 3.20e-01 4.70e-01
GAB1 signalosome 17 7.38e-01 8.31e-01 0.08920 0.031700 8.34e-02 8.21e-01 5.52e-01
Regulation of TP53 Activity through Association with Co-factors 14 8.09e-01 8.70e-01 0.08910 -0.081400 -3.63e-02 5.98e-01 8.14e-01
Interferon alpha/beta signaling 69 7.18e-03 4.29e-02 0.08910 0.073100 -5.08e-02 2.93e-01 4.65e-01
PI-3K cascade:FGFR3 17 2.89e-01 4.76e-01 0.08910 0.069300 -5.60e-02 6.21e-01 6.89e-01
Signaling by NOTCH2 32 6.03e-01 7.38e-01 0.08900 0.034900 8.18e-02 7.33e-01 4.23e-01
PI3K Cascade 43 3.99e-01 5.80e-01 0.08890 -0.025800 -8.51e-02 7.70e-01 3.34e-01
ADORA2B mediated anti-inflammatory cytokines production 42 5.55e-02 1.78e-01 0.08870 -0.076700 4.46e-02 3.90e-01 6.17e-01
Kinesins 42 7.26e-02 2.07e-01 0.08860 -0.082400 3.25e-02 3.55e-01 7.15e-01
Translation of Structural Proteins 9694635 55 6.34e-01 7.62e-01 0.08860 0.051200 7.23e-02 5.12e-01 3.54e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 4.92e-01 6.61e-01 0.08830 -0.087000 1.52e-02 5.73e-01 9.21e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 3.58e-01 5.42e-01 0.08810 0.081800 3.27e-02 2.65e-01 6.56e-01
Activation of the AP-1 family of transcription factors 10 5.22e-01 6.82e-01 0.08810 0.038300 -7.93e-02 8.34e-01 6.64e-01
Intracellular signaling by second messengers 313 9.58e-02 2.47e-01 0.08790 0.052900 7.02e-02 1.07e-01 3.24e-02
Chondroitin sulfate biosynthesis 18 8.79e-01 9.16e-01 0.08780 0.054400 6.89e-02 6.89e-01 6.13e-01
Hyaluronan uptake and degradation 12 9.27e-01 9.47e-01 0.08780 -0.062100 -6.21e-02 7.10e-01 7.10e-01
Regulated proteolysis of p75NTR 11 6.76e-01 7.84e-01 0.08750 -0.004170 -8.74e-02 9.81e-01 6.16e-01
FGFR2 mutant receptor activation 32 3.31e-01 5.16e-01 0.08700 0.086800 5.00e-03 3.95e-01 9.61e-01
Processive synthesis on the lagging strand 14 7.65e-01 8.39e-01 0.08680 0.082400 2.71e-02 5.93e-01 8.60e-01
FCERI mediated MAPK activation 29 8.10e-01 8.70e-01 0.08660 0.052400 6.90e-02 6.25e-01 5.20e-01
G-protein beta:gamma signalling 30 1.79e-01 3.58e-01 0.08640 -0.028200 8.17e-02 7.89e-01 4.39e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 4.13e-01 5.92e-01 0.08640 -0.069600 5.12e-02 6.64e-01 7.49e-01
Centrosome maturation 76 2.73e-01 4.62e-01 0.08610 0.029800 8.08e-02 6.53e-01 2.23e-01
Recruitment of mitotic centrosome proteins and complexes 76 2.73e-01 4.62e-01 0.08610 0.029800 8.08e-02 6.53e-01 2.23e-01
Immune System 1870 4.13e-06 1.36e-04 0.08570 0.051800 6.83e-02 1.84e-04 8.35e-07
Recycling pathway of L1 23 2.40e-01 4.22e-01 0.08560 -0.038400 7.65e-02 7.50e-01 5.25e-01
CD28 co-stimulation 32 1.13e-01 2.75e-01 0.08560 -0.060700 6.02e-02 5.52e-01 5.55e-01
Signaling by NTRK2 (TRKB) 25 8.08e-01 8.70e-01 0.08510 0.071300 4.64e-02 5.37e-01 6.88e-01
Azathioprine ADME 22 8.31e-01 8.85e-01 0.08480 0.046400 7.10e-02 7.07e-01 5.64e-01
Metabolism of proteins 1767 6.55e-05 1.21e-03 0.08450 0.058400 6.11e-02 4.10e-05 1.77e-05
HuR (ELAVL1) binds and stabilizes mRNA 10 9.10e-01 9.38e-01 0.08420 0.072400 4.30e-02 6.92e-01 8.14e-01
Signaling by KIT in disease 20 6.83e-01 7.90e-01 0.08400 0.024400 8.04e-02 8.50e-01 5.34e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 6.83e-01 7.90e-01 0.08400 0.024400 8.04e-02 8.50e-01 5.34e-01
CS/DS degradation 12 9.33e-01 9.52e-01 0.08400 0.059000 5.98e-02 7.24e-01 7.20e-01
Peptide ligand-binding receptors 190 3.27e-01 5.14e-01 0.08390 -0.055900 -6.25e-02 1.84e-01 1.37e-01
ER to Golgi Anterograde Transport 134 4.65e-01 6.44e-01 0.08370 0.058000 6.04e-02 2.46e-01 2.27e-01
CTNNB1 S33 mutants aren’t phosphorylated 14 6.45e-01 7.67e-01 0.08360 0.005640 8.34e-02 9.71e-01 5.89e-01
CTNNB1 S37 mutants aren’t phosphorylated 14 6.45e-01 7.67e-01 0.08360 0.005640 8.34e-02 9.71e-01 5.89e-01
CTNNB1 S45 mutants aren’t phosphorylated 14 6.45e-01 7.67e-01 0.08360 0.005640 8.34e-02 9.71e-01 5.89e-01
CTNNB1 T41 mutants aren’t phosphorylated 14 6.45e-01 7.67e-01 0.08360 0.005640 8.34e-02 9.71e-01 5.89e-01
Signaling by CTNNB1 phospho-site mutants 14 6.45e-01 7.67e-01 0.08360 0.005640 8.34e-02 9.71e-01 5.89e-01
Signaling by GSK3beta mutants 14 6.45e-01 7.67e-01 0.08360 0.005640 8.34e-02 9.71e-01 5.89e-01
Signaling by TGFB family members 118 3.77e-01 5.56e-01 0.08330 -0.045100 -7.00e-02 3.97e-01 1.89e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 6.21e-01 7.54e-01 0.08330 0.082700 1.01e-02 5.55e-01 9.43e-01
Formation of the cornified envelope 73 6.23e-01 7.54e-01 0.08320 -0.051300 -6.55e-02 4.49e-01 3.33e-01
Metabolism of folate and pterines 16 3.64e-01 5.47e-01 0.08320 -0.066400 5.01e-02 6.45e-01 7.29e-01
Elevation of cytosolic Ca2+ levels 16 7.84e-01 8.52e-01 0.08310 0.029900 7.75e-02 8.36e-01 5.91e-01
Signal transduction by L1 20 8.51e-01 8.99e-01 0.08280 -0.069400 -4.52e-02 5.91e-01 7.26e-01
Dissolution of Fibrin Clot 13 9.24e-01 9.46e-01 0.08270 0.063700 5.28e-02 6.91e-01 7.42e-01
Deadenylation of mRNA 25 5.43e-01 6.96e-01 0.08190 -0.080700 -1.39e-02 4.85e-01 9.04e-01
Activation of BH3-only proteins 30 2.66e-01 4.53e-01 0.08170 -0.015300 8.02e-02 8.85e-01 4.47e-01
PI-3K cascade:FGFR4 19 4.97e-01 6.64e-01 0.08150 0.004630 -8.14e-02 9.72e-01 5.39e-01
Loss of Nlp from mitotic centrosomes 65 4.87e-01 6.60e-01 0.08120 0.036100 7.28e-02 6.15e-01 3.10e-01
Loss of proteins required for interphase microtubule organization from the centrosome 65 4.87e-01 6.60e-01 0.08120 0.036100 7.28e-02 6.15e-01 3.10e-01
Mitochondrial calcium ion transport 22 7.61e-01 8.39e-01 0.08080 -0.032900 -7.38e-02 7.90e-01 5.49e-01
RAC3 GTPase cycle 84 2.11e-02 9.17e-02 0.08060 -0.078200 1.98e-02 2.15e-01 7.53e-01
PI-3K cascade:FGFR2 22 3.62e-01 5.45e-01 0.08060 0.020100 -7.80e-02 8.70e-01 5.26e-01
G alpha (z) signalling events 48 2.65e-01 4.52e-01 0.08040 -0.080100 -7.39e-03 3.37e-01 9.29e-01
Signaling by Retinoic Acid 41 6.61e-01 7.77e-01 0.08030 0.071100 3.73e-02 4.31e-01 6.79e-01
Signaling by FGFR 85 1.48e-01 3.19e-01 0.08030 0.078800 1.51e-02 2.09e-01 8.10e-01
Signaling by Erythropoietin 25 8.79e-01 9.16e-01 0.07970 0.056800 5.59e-02 6.23e-01 6.28e-01
Cargo trafficking to the periciliary membrane 49 7.76e-01 8.46e-01 0.07970 -0.055800 -5.68e-02 4.99e-01 4.91e-01
GRB2 events in ERBB2 signaling 16 6.59e-01 7.76e-01 0.07960 -0.079100 -8.93e-03 5.84e-01 9.51e-01
HDMs demethylate histones 18 7.87e-01 8.54e-01 0.07960 0.029900 7.37e-02 8.26e-01 5.88e-01
Rap1 signalling 16 3.97e-01 5.78e-01 0.07880 -0.055100 5.63e-02 7.03e-01 6.97e-01
GPER1 signaling 44 1.26e-01 2.97e-01 0.07880 -0.024700 7.48e-02 7.77e-01 3.90e-01
SHC1 events in ERBB2 signaling 22 2.86e-01 4.72e-01 0.07830 -0.057300 5.34e-02 6.42e-01 6.65e-01
FOXO-mediated transcription of cell death genes 15 8.82e-01 9.18e-01 0.07770 0.038800 6.73e-02 7.95e-01 6.52e-01
Signaling by ERBB2 TMD/JMD mutants 21 6.66e-01 7.80e-01 0.07760 0.017300 7.57e-02 8.91e-01 5.48e-01
CTLA4 inhibitory signaling 21 4.50e-01 6.30e-01 0.07730 -0.076400 1.20e-02 5.44e-01 9.24e-01
TCR signaling 112 5.71e-01 7.19e-01 0.07710 0.051300 5.76e-02 3.48e-01 2.92e-01
Cell surface interactions at the vascular wall 127 4.44e-01 6.25e-01 0.07710 0.044000 6.33e-02 3.92e-01 2.18e-01
Factors involved in megakaryocyte development and platelet production 128 2.40e-02 9.94e-02 0.07700 0.001150 7.70e-02 9.82e-01 1.32e-01
Interleukin-2 family signaling 40 3.77e-01 5.56e-01 0.07690 -0.076400 -8.41e-03 4.03e-01 9.27e-01
Golgi-to-ER retrograde transport 115 2.17e-01 4.03e-01 0.07670 -0.071800 -2.70e-02 1.83e-01 6.16e-01
Metal ion SLC transporters 25 2.94e-01 4.80e-01 0.07640 0.068700 -3.34e-02 5.52e-01 7.73e-01
Butyrophilin (BTN) family interactions 12 9.45e-01 9.59e-01 0.07610 -0.054900 -5.27e-02 7.42e-01 7.52e-01
MECP2 regulates neuronal receptors and channels 17 8.91e-01 9.25e-01 0.07560 -0.063500 -4.10e-02 6.50e-01 7.70e-01
ATF4 activates genes in response to endoplasmic reticulum stress 28 2.35e-01 4.18e-01 0.07520 0.060300 -4.50e-02 5.81e-01 6.80e-01
Aggrephagy 23 4.18e-01 5.97e-01 0.07500 -0.015200 7.34e-02 9.00e-01 5.42e-01
Constitutive Signaling by EGFRvIII 15 7.63e-01 8.39e-01 0.07490 0.016700 7.30e-02 9.11e-01 6.24e-01
Signaling by EGFRvIII in Cancer 15 7.63e-01 8.39e-01 0.07490 0.016700 7.30e-02 9.11e-01 6.24e-01
VEGFR2 mediated cell proliferation 19 9.01e-01 9.33e-01 0.07470 -0.044900 -5.97e-02 7.35e-01 6.53e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 41 2.92e-01 4.79e-01 0.07450 -0.074400 3.11e-03 4.10e-01 9.72e-01
RHO GTPase cycle 420 2.56e-06 9.44e-05 0.07440 -0.074200 4.97e-03 8.98e-03 8.61e-01
Deactivation of the beta-catenin transactivating complex 39 7.28e-01 8.22e-01 0.07420 0.035700 6.50e-02 7.00e-01 4.82e-01
Other interleukin signaling 24 4.63e-01 6.43e-01 0.07410 0.073800 -6.91e-03 5.32e-01 9.53e-01
RUNX3 regulates NOTCH signaling 13 5.17e-01 6.79e-01 0.07380 -0.051500 5.29e-02 7.48e-01 7.41e-01
Golgi Associated Vesicle Biogenesis 51 5.35e-01 6.92e-01 0.07370 0.026000 6.90e-02 7.48e-01 3.94e-01
Signaling by BRAF and RAF1 fusions 60 5.35e-02 1.74e-01 0.07290 -0.045600 5.69e-02 5.41e-01 4.46e-01
RHO GTPases activate PKNs 34 7.23e-01 8.18e-01 0.07280 -0.030800 -6.60e-02 7.56e-01 5.06e-01
G alpha (q) signalling events 206 2.63e-02 1.04e-01 0.07240 -0.070900 -1.45e-02 7.90e-02 7.20e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 6.95e-01 7.99e-01 0.07190 0.019700 6.91e-02 8.65e-01 5.50e-01
CD28 dependent Vav1 pathway 11 6.41e-01 7.67e-01 0.07170 -0.067100 2.53e-02 7.00e-01 8.84e-01
Signaling by VEGF 101 9.93e-03 5.42e-02 0.07120 -0.058500 4.06e-02 3.09e-01 4.81e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 6.81e-01 7.89e-01 0.07120 -0.006430 7.09e-02 9.68e-01 6.58e-01
Defects in cobalamin (B12) metabolism 12 8.89e-01 9.24e-01 0.07100 -0.028500 -6.51e-02 8.64e-01 6.96e-01
VEGFA-VEGFR2 Pathway 93 1.72e-02 8.06e-02 0.07040 -0.036600 6.02e-02 5.42e-01 3.16e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 12 9.17e-01 9.42e-01 0.07040 0.034100 6.15e-02 8.38e-01 7.12e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 5.45e-01 6.98e-01 0.07030 0.066700 2.23e-02 4.19e-01 7.87e-01
RUNX2 regulates osteoblast differentiation 22 9.13e-01 9.41e-01 0.07030 -0.047400 -5.19e-02 7.00e-01 6.73e-01
PIWI-interacting RNA (piRNA) biogenesis 29 5.00e-01 6.68e-01 0.07030 -0.070300 -1.83e-03 5.13e-01 9.86e-01
GPCR ligand binding 443 1.78e-01 3.56e-01 0.06940 -0.050500 -4.77e-02 6.82e-02 8.48e-02
Activation of BAD and translocation to mitochondria 15 7.02e-01 8.05e-01 0.06930 -0.069300 -1.19e-03 6.42e-01 9.94e-01
Post-translational protein modification 1289 3.85e-03 2.77e-02 0.06920 0.042500 5.47e-02 1.00e-02 9.21e-04
Downregulation of SMAD2/3:SMAD4 transcriptional activity 29 7.09e-01 8.08e-01 0.06910 0.065400 2.21e-02 5.42e-01 8.37e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 5.91e-01 7.33e-01 0.06890 -0.052700 4.44e-02 7.52e-01 7.90e-01
Platelet degranulation 115 3.97e-01 5.78e-01 0.06860 -0.061600 -3.00e-02 2.53e-01 5.78e-01
Resolution of D-Loop Structures 31 7.84e-01 8.52e-01 0.06840 0.030400 6.13e-02 7.70e-01 5.55e-01
RAC2 GTPase cycle 80 3.56e-02 1.32e-01 0.06790 -0.055500 3.92e-02 3.91e-01 5.45e-01
Peptide hormone biosynthesis 11 8.57e-01 9.03e-01 0.06780 -0.016500 -6.58e-02 9.24e-01 7.06e-01
Defensins 36 8.74e-01 9.13e-01 0.06770 -0.048400 -4.74e-02 6.15e-01 6.23e-01
Disorders of transmembrane transporters 167 5.21e-01 6.82e-01 0.06710 0.043300 5.12e-02 3.34e-01 2.54e-01
Response to elevated platelet cytosolic Ca2+ 120 4.77e-01 6.54e-01 0.06710 -0.058000 -3.36e-02 2.72e-01 5.25e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 20 9.24e-01 9.46e-01 0.06700 0.051300 4.31e-02 6.91e-01 7.39e-01
Meiotic recombination 26 3.95e-01 5.76e-01 0.06680 -0.061900 2.51e-02 5.85e-01 8.25e-01
ESR-mediated signaling 160 3.24e-01 5.11e-01 0.06670 0.030700 5.92e-02 5.03e-01 1.96e-01
Protein folding 96 5.24e-01 6.84e-01 0.06670 0.058700 3.16e-02 3.20e-01 5.93e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 30 7.90e-01 8.56e-01 0.06570 0.027600 5.96e-02 7.94e-01 5.72e-01
Signaling by NOTCH1 69 2.38e-01 4.20e-01 0.06530 0.001280 6.53e-02 9.85e-01 3.48e-01
N-glycan antennae elongation in the medial/trans-Golgi 26 6.56e-01 7.75e-01 0.06530 -0.064500 -9.74e-03 5.69e-01 9.32e-01
Constitutive Signaling by Aberrant PI3K in Cancer 77 7.63e-01 8.39e-01 0.06490 -0.043600 -4.81e-02 5.08e-01 4.66e-01
Insulin receptor signalling cascade 53 3.30e-01 5.16e-01 0.06460 -0.000360 -6.46e-02 9.96e-01 4.16e-01
Adaptive Immune System 709 8.98e-03 5.01e-02 0.06460 0.029200 5.76e-02 1.84e-01 8.79e-03
FLT3 Signaling 38 6.55e-01 7.75e-01 0.06450 0.019000 6.17e-02 8.39e-01 5.11e-01
Methylation 14 7.46e-01 8.35e-01 0.06420 0.064200 -1.95e-04 6.78e-01 9.99e-01
Fatty acid metabolism 167 5.73e-01 7.20e-01 0.06410 0.045200 4.55e-02 3.13e-01 3.11e-01
IRS-related events triggered by IGF1R 50 4.62e-01 6.42e-01 0.06400 -0.009860 -6.33e-02 9.04e-01 4.39e-01
PERK regulates gene expression 32 4.15e-01 5.94e-01 0.06350 0.062000 -1.34e-02 5.44e-01 8.95e-01
RHO GTPases Activate Formins 114 6.51e-01 7.72e-01 0.06340 0.049900 3.91e-02 3.57e-01 4.71e-01
NOTCH3 Intracellular Domain Regulates Transcription 24 7.03e-01 8.05e-01 0.06320 0.010400 6.24e-02 9.30e-01 5.97e-01
FOXO-mediated transcription of cell cycle genes 16 7.05e-01 8.08e-01 0.06310 -0.063000 3.20e-03 6.63e-01 9.82e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 5.79e-01 7.25e-01 0.06270 0.062100 8.97e-03 5.19e-01 9.26e-01
Meiosis 56 1.73e-01 3.50e-01 0.06250 -0.023700 5.78e-02 7.59e-01 4.54e-01
Formation of tubulin folding intermediates by CCT/TriC 26 4.61e-01 6.40e-01 0.06240 0.059000 -2.02e-02 6.02e-01 8.58e-01
ROS and RNS production in phagocytes 35 3.03e-01 4.90e-01 0.06200 0.052500 -3.30e-02 5.91e-01 7.35e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 52 4.77e-01 6.54e-01 0.06160 -0.009570 -6.08e-02 9.05e-01 4.48e-01
Glycosaminoglycan metabolism 116 4.66e-01 6.44e-01 0.06150 -0.055500 -2.67e-02 3.02e-01 6.20e-01
Glycerophospholipid biosynthesis 114 5.75e-01 7.22e-01 0.06150 -0.052500 -3.20e-02 3.32e-01 5.55e-01
The canonical retinoid cycle in rods (twilight vision) 23 9.25e-01 9.46e-01 0.06070 -0.047500 -3.78e-02 6.94e-01 7.54e-01
Free fatty acids regulate insulin secretion 10 7.16e-01 8.13e-01 0.06000 -0.041000 4.37e-02 8.22e-01 8.11e-01
Arachidonic acid metabolism 56 7.91e-01 8.57e-01 0.05990 0.050100 3.28e-02 5.17e-01 6.71e-01
Transport to the Golgi and subsequent modification 165 5.96e-01 7.36e-01 0.05940 0.037900 4.58e-02 4.01e-01 3.09e-01
Oncogenic MAPK signaling 76 8.82e-02 2.33e-01 0.05870 -0.040300 4.27e-02 5.43e-01 5.20e-01
IRS-mediated signalling 47 4.86e-01 6.60e-01 0.05810 -0.003430 -5.80e-02 9.68e-01 4.91e-01
Class B/2 (Secretin family receptors) 94 5.10e-01 6.75e-01 0.05760 0.053600 2.11e-02 3.69e-01 7.23e-01
Chaperonin-mediated protein folding 90 4.51e-01 6.31e-01 0.05740 0.054900 1.67e-02 3.68e-01 7.84e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 43 8.93e-01 9.26e-01 0.05680 -0.039900 -4.05e-02 6.51e-01 6.46e-01
Nucleotide catabolism 35 9.09e-01 9.38e-01 0.05670 -0.042300 -3.78e-02 6.65e-01 6.99e-01
Regulation of insulin secretion 77 2.33e-01 4.15e-01 0.05650 -0.056200 5.88e-03 3.93e-01 9.29e-01
Cargo recognition for clathrin-mediated endocytosis 98 4.17e-01 5.96e-01 0.05640 0.015600 5.42e-02 7.90e-01 3.53e-01
Synthesis of PIPs at the Golgi membrane 17 8.81e-01 9.18e-01 0.05600 0.018900 5.27e-02 8.93e-01 7.07e-01
DAP12 signaling 28 9.19e-01 9.43e-01 0.05580 0.033700 4.45e-02 7.57e-01 6.84e-01
Keratan sulfate degradation 12 9.18e-01 9.43e-01 0.05560 -0.052200 -1.93e-02 7.54e-01 9.08e-01
Interleukin-4 and Interleukin-13 signaling 104 7.62e-01 8.39e-01 0.05510 0.035900 4.18e-02 5.26e-01 4.61e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 23 8.68e-01 9.10e-01 0.05500 -0.050700 -2.13e-02 6.74e-01 8.59e-01
WNT5A-dependent internalization of FZD4 15 9.10e-01 9.38e-01 0.05500 0.020900 5.08e-02 8.88e-01 7.33e-01
Membrane Trafficking 585 6.64e-02 1.96e-01 0.05500 0.025500 4.87e-02 2.91e-01 4.38e-02
Regulation of IFNG signaling 14 6.87e-01 7.92e-01 0.05470 0.045700 -3.01e-02 7.67e-01 8.45e-01
Synthesis of PIPs at the plasma membrane 48 5.70e-01 7.19e-01 0.05460 -0.054100 -7.32e-03 5.17e-01 9.30e-01
Lagging Strand Synthesis 19 7.33e-01 8.26e-01 0.05450 0.054500 -2.79e-03 6.81e-01 9.83e-01
Signaling by ERBB2 KD Mutants 24 5.28e-01 6.87e-01 0.05450 -0.045500 3.00e-02 7.00e-01 7.99e-01
Association of TriC/CCT with target proteins during biosynthesis 38 3.50e-01 5.34e-01 0.05450 0.038900 -3.82e-02 6.78e-01 6.84e-01
Platelet sensitization by LDL 17 9.59e-01 9.69e-01 0.05440 0.039800 3.71e-02 7.76e-01 7.91e-01
Glycogen metabolism 22 9.43e-01 9.58e-01 0.05430 0.034200 4.22e-02 7.81e-01 7.32e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 38 5.73e-01 7.20e-01 0.05420 0.000355 5.42e-02 9.97e-01 5.63e-01
EPH-Ephrin signaling 90 8.03e-01 8.67e-01 0.05410 -0.040100 -3.63e-02 5.10e-01 5.52e-01
Nuclear Receptor transcription pathway 51 4.94e-01 6.61e-01 0.05410 -0.054000 -2.00e-03 5.04e-01 9.80e-01
Signaling by Non-Receptor Tyrosine Kinases 55 3.31e-01 5.16e-01 0.05370 -0.012600 5.22e-02 8.72e-01 5.03e-01
Signaling by PTK6 55 3.31e-01 5.16e-01 0.05370 -0.012600 5.22e-02 8.72e-01 5.03e-01
Metabolism of Angiotensinogen to Angiotensins 15 9.63e-01 9.71e-01 0.05350 -0.040700 -3.48e-02 7.85e-01 8.16e-01
Regulation of gene expression in beta cells 21 7.25e-01 8.20e-01 0.05350 0.001780 -5.35e-02 9.89e-01 6.71e-01
Signaling by ERBB2 in Cancer 25 5.22e-01 6.82e-01 0.05340 -0.043100 3.16e-02 7.09e-01 7.85e-01
Signaling by FGFR2 in disease 42 4.21e-01 5.98e-01 0.05340 0.051400 -1.43e-02 5.64e-01 8.73e-01
Insulin receptor recycling 26 6.50e-01 7.71e-01 0.05320 0.053000 -5.00e-03 6.40e-01 9.65e-01
Signaling by ERBB4 57 2.42e-01 4.24e-01 0.05320 -0.045500 2.75e-02 5.52e-01 7.19e-01
Peptide hormone metabolism 83 1.87e-01 3.66e-01 0.05280 -0.050800 1.43e-02 4.23e-01 8.21e-01
Integration of energy metabolism 106 2.48e-01 4.32e-01 0.05220 -0.052200 -1.31e-03 3.53e-01 9.81e-01
Removal of the Flap Intermediate 13 9.72e-01 9.76e-01 0.05180 0.035300 3.79e-02 8.25e-01 8.13e-01
Keratan sulfate biosynthesis 28 9.05e-01 9.35e-01 0.05180 -0.026400 -4.45e-02 8.09e-01 6.83e-01
Organelle biogenesis and maintenance 243 3.10e-01 4.96e-01 0.05170 0.021700 4.69e-02 5.59e-01 2.08e-01
Voltage gated Potassium channels 42 8.46e-01 8.97e-01 0.05110 -0.045100 -2.41e-02 6.13e-01 7.87e-01
Diseases of carbohydrate metabolism 30 4.96e-01 6.63e-01 0.05070 -0.040700 3.01e-02 6.99e-01 7.75e-01
Basigin interactions 24 9.51e-01 9.64e-01 0.05060 0.034600 3.70e-02 7.69e-01 7.54e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 37 4.37e-01 6.15e-01 0.05060 -0.025400 4.37e-02 7.89e-01 6.45e-01
Nervous system development 527 1.16e-01 2.78e-01 0.05050 -0.045100 -2.29e-02 7.61e-02 3.68e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 120 1.93e-01 3.76e-01 0.05000 0.002560 -5.00e-02 9.61e-01 3.44e-01
Retrograde neurotrophin signalling 14 7.32e-01 8.25e-01 0.04980 -0.027600 4.15e-02 8.58e-01 7.88e-01
Transcriptional Regulation by MECP2 60 2.92e-01 4.79e-01 0.04920 -0.044000 2.22e-02 5.56e-01 7.66e-01
Glucagon-type ligand receptors 33 7.63e-01 8.39e-01 0.04920 -0.048200 -9.91e-03 6.32e-01 9.22e-01
Downstream signal transduction 29 9.42e-01 9.57e-01 0.04920 0.037000 3.24e-02 7.30e-01 7.62e-01
Sema4D in semaphorin signaling 24 8.10e-01 8.70e-01 0.04900 0.008290 4.83e-02 9.44e-01 6.82e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 181 1.52e-01 3.23e-01 0.04890 -0.048700 -3.88e-03 2.58e-01 9.28e-01
Signaling by FGFR in disease 61 8.67e-01 9.09e-01 0.04880 0.039100 2.92e-02 5.98e-01 6.93e-01
PI3K/AKT Signaling in Cancer 103 8.05e-01 8.69e-01 0.04860 -0.037500 -3.10e-02 5.11e-01 5.87e-01
Metabolism 1963 2.84e-02 1.11e-01 0.04860 0.032800 3.58e-02 1.55e-02 8.22e-03
Signaling by NTRK3 (TRKC) 17 7.13e-01 8.11e-01 0.04800 0.042200 -2.29e-02 7.63e-01 8.70e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 8.66e-01 9.09e-01 0.04770 0.012700 4.59e-02 9.18e-01 7.09e-01
RHOBTB2 GTPase cycle 22 7.63e-01 8.39e-01 0.04770 0.047600 -1.94e-03 6.99e-01 9.87e-01
Signaling by Rho GTPases 589 1.73e-04 2.46e-03 0.04720 -0.046200 9.56e-03 5.47e-02 6.91e-01
Beta-catenin independent WNT signaling 144 5.81e-01 7.25e-01 0.04670 0.020300 4.21e-02 6.74e-01 3.83e-01
PECAM1 interactions 12 9.68e-01 9.74e-01 0.04660 -0.024600 -3.95e-02 8.83e-01 8.13e-01
Signaling by Leptin 11 9.39e-01 9.56e-01 0.04630 0.013600 4.42e-02 9.38e-01 8.00e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 7.46e-01 8.35e-01 0.04600 0.028700 -3.60e-02 8.47e-01 8.09e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 7.46e-01 8.35e-01 0.04600 0.028700 -3.60e-02 8.47e-01 8.09e-01
Signaling by RAF1 mutants 37 4.88e-01 6.60e-01 0.04570 -0.032200 3.24e-02 7.34e-01 7.33e-01
RNA Polymerase III Transcription Termination 23 9.62e-01 9.70e-01 0.04520 0.032800 3.11e-02 7.85e-01 7.96e-01
Signaling by WNT 263 4.57e-01 6.37e-01 0.04510 0.021700 3.95e-02 5.44e-01 2.69e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 21 8.50e-01 8.99e-01 0.04460 -0.044200 -6.13e-03 7.26e-01 9.61e-01
Signaling by Insulin receptor 77 2.61e-01 4.49e-01 0.04420 0.024300 -3.69e-02 7.12e-01 5.76e-01
IGF1R signaling cascade 51 5.12e-01 6.75e-01 0.04410 0.008990 -4.32e-02 9.12e-01 5.93e-01
TNFs bind their physiological receptors 25 8.25e-01 8.83e-01 0.04300 0.004650 4.28e-02 9.68e-01 7.11e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 603 3.03e-04 3.55e-03 0.04280 -0.040800 1.29e-02 8.62e-02 5.88e-01
Phospholipid metabolism 192 4.39e-01 6.18e-01 0.04270 -0.040200 -1.44e-02 3.36e-01 7.31e-01
Intraflagellar transport 36 7.19e-01 8.15e-01 0.04270 -0.042700 -1.32e-04 6.58e-01 9.99e-01
RAS processing 19 9.58e-01 9.69e-01 0.04270 -0.022600 -3.62e-02 8.65e-01 7.85e-01
The role of Nef in HIV-1 replication and disease pathogenesis 27 7.11e-01 8.10e-01 0.04260 -0.041400 9.81e-03 7.09e-01 9.30e-01
Fcgamma receptor (FCGR) dependent phagocytosis 82 3.77e-01 5.56e-01 0.04220 -0.008350 4.13e-02 8.96e-01 5.17e-01
COPI-dependent Golgi-to-ER retrograde traffic 81 2.97e-01 4.83e-01 0.04180 -0.036900 1.98e-02 5.66e-01 7.58e-01
Class A/1 (Rhodopsin-like receptors) 311 5.84e-01 7.28e-01 0.04180 -0.024800 -3.36e-02 4.51e-01 3.08e-01
Amyloid fiber formation 53 4.31e-01 6.09e-01 0.04180 -0.024800 3.36e-02 7.55e-01 6.72e-01
Regulation of actin dynamics for phagocytic cup formation 59 8.58e-01 9.03e-01 0.04170 0.019900 3.66e-02 7.91e-01 6.27e-01
Metabolism of vitamins and cofactors 181 6.13e-01 7.47e-01 0.04160 -0.036900 -1.93e-02 3.92e-01 6.54e-01
Developmental Biology 1027 5.54e-02 1.78e-01 0.04120 -0.037100 -1.80e-02 4.36e-02 3.27e-01
Nicotinate metabolism 29 9.19e-01 9.43e-01 0.04040 -0.017300 -3.66e-02 8.72e-01 7.33e-01
Leishmania infection 156 3.35e-01 5.22e-01 0.04020 0.003330 4.01e-02 9.43e-01 3.88e-01
Plasma lipoprotein clearance 37 9.54e-01 9.67e-01 0.03940 0.027200 2.85e-02 7.75e-01 7.64e-01
Antimicrobial peptides 78 9.06e-01 9.36e-01 0.03920 -0.028400 -2.70e-02 6.64e-01 6.80e-01
Downregulation of TGF-beta receptor signaling 26 9.67e-01 9.74e-01 0.03920 -0.029200 -2.61e-02 7.97e-01 8.18e-01
Transferrin endocytosis and recycling 30 7.62e-01 8.39e-01 0.03910 0.038900 -4.04e-03 7.12e-01 9.69e-01
Axon guidance 503 3.14e-01 5.01e-01 0.03900 -0.034500 -1.83e-02 1.85e-01 4.82e-01
Intrinsic Pathway for Apoptosis 52 4.81e-01 6.59e-01 0.03890 -0.028200 2.69e-02 7.25e-01 7.37e-01
Phase II - Conjugation of compounds 106 8.14e-01 8.71e-01 0.03820 -0.019400 -3.29e-02 7.29e-01 5.59e-01
Signal Transduction 2409 6.42e-05 1.21e-03 0.03820 -0.037000 -9.41e-03 2.75e-03 4.46e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 8.30e-01 8.85e-01 0.03810 0.029600 -2.39e-02 8.48e-01 8.77e-01
Clathrin-mediated endocytosis 135 8.28e-01 8.85e-01 0.03750 0.022400 3.01e-02 6.53e-01 5.45e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 6.32e-01 7.60e-01 0.03730 -0.014200 3.45e-02 8.75e-01 7.02e-01
Signaling by RAS mutants 41 6.32e-01 7.60e-01 0.03730 -0.014200 3.45e-02 8.75e-01 7.02e-01
Signaling by moderate kinase activity BRAF mutants 41 6.32e-01 7.60e-01 0.03730 -0.014200 3.45e-02 8.75e-01 7.02e-01
Signaling downstream of RAS mutants 41 6.32e-01 7.60e-01 0.03730 -0.014200 3.45e-02 8.75e-01 7.02e-01
Integrin signaling 27 7.53e-01 8.39e-01 0.03700 -0.035000 1.20e-02 7.53e-01 9.14e-01
FOXO-mediated transcription 65 6.03e-01 7.38e-01 0.03700 -0.036900 2.80e-03 6.07e-01 9.69e-01
Vesicle-mediated transport 623 9.46e-02 2.44e-01 0.03690 0.009980 3.55e-02 6.70e-01 1.29e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29 9.34e-01 9.52e-01 0.03600 -0.032600 -1.51e-02 7.61e-01 8.88e-01
MHC class II antigen presentation 104 5.99e-01 7.36e-01 0.03560 0.004870 3.52e-02 9.32e-01 5.34e-01
Surfactant metabolism 28 8.29e-01 8.85e-01 0.03540 0.001170 -3.54e-02 9.91e-01 7.46e-01
Signaling by Nuclear Receptors 237 7.31e-01 8.25e-01 0.03530 0.020300 2.89e-02 5.90e-01 4.43e-01
Translation of Structural Proteins 9683701 29 7.23e-01 8.19e-01 0.03490 0.027700 -2.13e-02 7.96e-01 8.43e-01
Signaling by NOTCH3 48 5.89e-01 7.32e-01 0.03480 -0.021000 2.77e-02 8.01e-01 7.40e-01
Pregnenolone biosynthesis 10 9.31e-01 9.50e-01 0.03410 0.033800 -4.40e-03 8.53e-01 9.81e-01
Signaling by MET 66 4.94e-01 6.61e-01 0.03400 -0.026000 2.20e-02 7.15e-01 7.57e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 7.74e-01 8.44e-01 0.03370 -0.019100 2.77e-02 8.69e-01 8.10e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 37 7.59e-01 8.39e-01 0.03340 0.032800 -6.52e-03 7.30e-01 9.45e-01
Sema4D induced cell migration and growth-cone collapse 20 9.80e-01 9.83e-01 0.03330 0.020800 2.60e-02 8.72e-01 8.41e-01
Death Receptor Signalling 134 3.68e-01 5.51e-01 0.03250 -0.008050 3.15e-02 8.72e-01 5.29e-01
Metabolism of lipids 696 6.87e-02 2.01e-01 0.03250 -0.032100 -5.07e-03 1.48e-01 8.19e-01
Gluconeogenesis 32 9.71e-01 9.76e-01 0.03150 -0.019400 -2.48e-02 8.49e-01 8.08e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 104 9.03e-01 9.33e-01 0.03140 -0.018700 -2.53e-02 7.42e-01 6.56e-01
Chondroitin sulfate/dermatan sulfate metabolism 45 7.47e-01 8.35e-01 0.03130 -0.030700 5.94e-03 7.21e-01 9.45e-01
Amine ligand-binding receptors 41 9.58e-01 9.69e-01 0.03110 0.025600 1.76e-02 7.77e-01 8.45e-01
Defects in vitamin and cofactor metabolism 20 8.39e-01 8.91e-01 0.03100 -0.024300 1.92e-02 8.51e-01 8.82e-01
Chaperone Mediated Autophagy 19 8.93e-01 9.26e-01 0.03060 -0.004790 3.02e-02 9.71e-01 8.20e-01
SLC transporter disorders 92 5.13e-01 6.75e-01 0.03000 -0.027700 1.15e-02 6.46e-01 8.48e-01
Hemostasis 555 1.13e-02 6.02e-02 0.02980 -0.022200 1.99e-02 3.71e-01 4.21e-01
Negative regulation of the PI3K/AKT network 111 8.50e-01 8.99e-01 0.02950 -0.026500 -1.31e-02 6.30e-01 8.11e-01
Late SARS-CoV-2 Infection Events 67 6.44e-01 7.67e-01 0.02910 -0.027400 9.83e-03 6.98e-01 8.89e-01
Apoptotic factor-mediated response 17 9.74e-01 9.78e-01 0.02910 -0.026500 -1.22e-02 8.50e-01 9.31e-01
EPHB-mediated forward signaling 34 7.70e-01 8.41e-01 0.02910 -0.023400 1.73e-02 8.13e-01 8.62e-01
Intra-Golgi traffic 43 7.67e-01 8.41e-01 0.02860 -0.027200 8.82e-03 7.57e-01 9.20e-01
Circadian Clock 69 5.95e-01 7.36e-01 0.02840 -0.020000 2.03e-02 7.74e-01 7.71e-01
Signaling by PDGFRA extracellular domain mutants 12 9.16e-01 9.42e-01 0.02800 -0.019200 2.04e-02 9.08e-01 9.02e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 9.16e-01 9.42e-01 0.02800 -0.019200 2.04e-02 9.08e-01 9.02e-01
Keratan sulfate/keratin metabolism 33 8.86e-01 9.21e-01 0.02760 0.027600 7.80e-04 7.84e-01 9.94e-01
Sphingolipid metabolism 81 9.51e-01 9.64e-01 0.02750 0.020100 1.88e-02 7.55e-01 7.70e-01
Interferon gamma signaling 89 7.08e-01 8.08e-01 0.02670 0.026600 -1.29e-03 6.64e-01 9.83e-01
DAP12 interactions 40 8.48e-01 8.98e-01 0.02610 0.025900 -3.11e-03 7.77e-01 9.73e-01
Regulation of MECP2 expression and activity 30 8.61e-01 9.06e-01 0.02570 -0.024500 7.86e-03 8.16e-01 9.41e-01
PI Metabolism 79 7.51e-01 8.38e-01 0.02560 -0.025600 1.50e-03 6.94e-01 9.82e-01
Platelet activation, signaling and aggregation 245 2.49e-01 4.32e-01 0.02540 -0.013400 2.16e-02 7.17e-01 5.60e-01
Metabolism of carbohydrates 275 7.96e-01 8.61e-01 0.02510 0.012800 2.16e-02 7.14e-01 5.37e-01
RAF activation 33 8.67e-01 9.09e-01 0.02510 -0.024500 5.51e-03 8.08e-01 9.56e-01
Metabolism of water-soluble vitamins and cofactors 118 5.07e-01 6.73e-01 0.02510 -0.019800 1.54e-02 7.10e-01 7.72e-01
Sialic acid metabolism 33 9.68e-01 9.74e-01 0.02470 -0.011400 -2.19e-02 9.10e-01 8.27e-01
Hyaluronan metabolism 17 9.22e-01 9.46e-01 0.02460 -0.008710 2.30e-02 9.50e-01 8.70e-01
Cilium Assembly 174 5.85e-01 7.28e-01 0.02450 -0.024500 2.96e-04 5.77e-01 9.95e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 8.74e-01 9.13e-01 0.02430 -0.019700 1.43e-02 8.65e-01 9.02e-01
Transport of vitamins, nucleosides, and related molecules 38 8.33e-01 8.87e-01 0.02420 -0.022200 9.73e-03 8.13e-01 9.17e-01
RHO GTPase Effectors 232 8.87e-01 9.22e-01 0.02350 0.014400 1.86e-02 7.05e-01 6.26e-01
Signaling by Receptor Tyrosine Kinases 493 1.43e-01 3.14e-01 0.02350 -0.022500 6.50e-03 3.91e-01 8.05e-01
FCGR3A-mediated phagocytosis 57 7.70e-01 8.41e-01 0.02280 -0.012000 1.94e-02 8.76e-01 8.00e-01
Leishmania phagocytosis 57 7.70e-01 8.41e-01 0.02280 -0.012000 1.94e-02 8.76e-01 8.00e-01
Parasite infection 57 7.70e-01 8.41e-01 0.02280 -0.012000 1.94e-02 8.76e-01 8.00e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 38 8.47e-01 8.97e-01 0.02170 -0.014700 1.60e-02 8.76e-01 8.64e-01
RAB GEFs exchange GTP for GDP on RABs 82 7.01e-01 8.05e-01 0.02170 0.013700 -1.68e-02 8.30e-01 7.92e-01
Extra-nuclear estrogen signaling 73 7.47e-01 8.35e-01 0.02140 -0.010800 1.84e-02 8.73e-01 7.85e-01
Signaling by SCF-KIT 43 9.24e-01 9.46e-01 0.02050 0.001730 2.05e-02 9.84e-01 8.16e-01
Interleukin-37 signaling 20 9.35e-01 9.52e-01 0.01990 -0.008950 1.78e-02 9.45e-01 8.91e-01
COPI-mediated anterograde transport 83 8.08e-01 8.70e-01 0.01940 0.004220 -1.89e-02 9.47e-01 7.66e-01
Deadenylation-dependent mRNA decay 56 8.69e-01 9.10e-01 0.01640 -0.011800 1.14e-02 8.78e-01 8.82e-01
RAF/MAP kinase cascade 264 9.40e-01 9.56e-01 0.01590 0.012500 9.85e-03 7.27e-01 7.83e-01
Anchoring of the basal body to the plasma membrane 92 8.62e-01 9.06e-01 0.01450 -0.013700 4.73e-03 8.20e-01 9.38e-01
Signaling by TGF-beta Receptor Complex 90 9.00e-01 9.32e-01 0.01440 0.014400 -9.71e-04 8.13e-01 9.87e-01
MAPK1/MAPK3 signaling 270 9.61e-01 9.70e-01 0.01350 0.009360 9.76e-03 7.91e-01 7.82e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 21 9.90e-01 9.91e-01 0.01310 0.012600 3.39e-03 9.20e-01 9.79e-01
MicroRNA (miRNA) biogenesis 26 9.62e-01 9.70e-01 0.01260 0.009130 -8.73e-03 9.36e-01 9.39e-01
RMTs methylate histone arginines 30 9.59e-01 9.69e-01 0.01230 -0.008010 9.39e-03 9.39e-01 9.29e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 9.87e-01 9.89e-01 0.01080 -0.010500 2.66e-03 9.42e-01 9.85e-01
Platelet Aggregation (Plug Formation) 37 9.90e-01 9.91e-01 0.00898 -0.001680 -8.82e-03 9.86e-01 9.26e-01
EPH-ephrin mediated repulsion of cells 48 9.95e-01 9.95e-01 0.00454 -0.000114 4.54e-03 9.99e-01 9.57e-01
MAPK family signaling cascades 311 9.94e-01 9.95e-01 0.00206 0.002060 8.44e-05 9.50e-01 9.98e-01


Detailed Gene set reports


cGMP effects

cGMP effects
metric value
setSize 15
pMANOVA 2.95e-05
p.adjustMANOVA 0.000651
s.dist 0.801
s.t -0.658
s.fry -0.457
p.t 1.01e-05
p.fry 0.00219




Top 20 genes
Gene t fry
PDE5A -17423.5 -15125
KCNMB3 -16930.5 -14074
KCNMB4 -14491.5 -16325
PDE11A -17608.5 -13161
PDE1A -17639.5 -12369
PDE2A -13386.5 -16010
PRKG2 -14847.5 -13712
KCNMB2 -17679.5 -10724
KCNMB1 -12369.5 -13092
KCNMA1 -17277.5 -8980
PDE10A -16597.5 -8628
PRKG1 -15076.5 -8007
PDE9A -5860.5 -7341
PDE1B -3345.5 -2177
ITPR1 -703.5 -1796

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All member genes
t fry
ITPR1 -703.5 -1796
KCNMA1 -17277.5 -8980
KCNMB1 -12369.5 -13092
KCNMB2 -17679.5 -10724
KCNMB3 -16930.5 -14074
KCNMB4 -14491.5 -16325
PDE10A -16597.5 -8628
PDE11A -17608.5 -13161
PDE1A -17639.5 -12369
PDE1B -3345.5 -2177
PDE2A -13386.5 -16010
PDE5A -17423.5 -15125
PDE9A -5860.5 -7341
PRKG1 -15076.5 -8007
PRKG2 -14847.5 -13712



Nitric oxide stimulates guanylate cyclase

Nitric oxide stimulates guanylate cyclase
metric value
setSize 22
pMANOVA 5.3e-05
p.adjustMANOVA 0.00105
s.dist 0.654
s.t -0.532
s.fry -0.38
p.t 1.54e-05
p.fry 0.00205




Top 20 genes
Gene t fry
PDE5A -17423.5 -15125
NOS2 -14886.5 -16089
KCNMB3 -16930.5 -14074
KCNMB4 -14491.5 -16325
PDE11A -17608.5 -13161
PDE1A -17639.5 -12369
PDE2A -13386.5 -16010
PRKG2 -14847.5 -13712
KCNMB2 -17679.5 -10724
KCNMB1 -12369.5 -13092
KCNMA1 -17277.5 -8980
PDE10A -16597.5 -8628
NOS3 -11579.5 -11534
PRKG1 -15076.5 -8007
NOS1 -9612.5 -11139
GUCY1B2 -11716.5 -6813
PDE9A -5860.5 -7341
GUCY1B3 -6898.5 -5112
GUCY1A2 -4246.5 -2374
PDE1B -3345.5 -2177

Click HERE to show all gene set members

All member genes
t fry
GUCY1A2 -4246.5 -2374
GUCY1A3 628.5 -478
GUCY1B2 -11716.5 -6813
GUCY1B3 -6898.5 -5112
ITPR1 -703.5 -1796
KCNMA1 -17277.5 -8980
KCNMB1 -12369.5 -13092
KCNMB2 -17679.5 -10724
KCNMB3 -16930.5 -14074
KCNMB4 -14491.5 -16325
NOS1 -9612.5 -11139
NOS2 -14886.5 -16089
NOS3 -11579.5 -11534
PDE10A -16597.5 -8628
PDE11A -17608.5 -13161
PDE1A -17639.5 -12369
PDE1B -3345.5 -2177
PDE2A -13386.5 -16010
PDE5A -17423.5 -15125
PDE9A -5860.5 -7341
PRKG1 -15076.5 -8007
PRKG2 -14847.5 -13712



Early Phase of HIV Life Cycle

Early Phase of HIV Life Cycle
metric value
setSize 14
pMANOVA 0.0062
p.adjustMANOVA 0.0385
s.dist 0.647
s.t 0.42
s.fry 0.492
p.t 0.00656
p.fry 0.00144




Top 20 genes
Gene t fry
HMGA1 6186.5 6591
PPIA 6042.5 6418
XRCC6 5208.5 6806
FEN1 5465.5 4764
BANF1 4953.5 5090
XRCC4 3623.5 3289
CD4 1549.5 2683

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All member genes
t fry
BANF1 4953.5 5090
CCR5 -1288.5 2332
CD4 1549.5 2683
CXCR4 -1303.5 2339
FEN1 5465.5 4764
HMGA1 6186.5 6591
KPNA1 -2199.5 -615
LIG1 3972.5 -6346
LIG4 -5501.5 3175
PPIA 6042.5 6418
PSIP1 -10720.5 -6874
XRCC4 3623.5 3289
XRCC5 -9936.5 -9722
XRCC6 5208.5 6806



Collagen chain trimerization

Collagen chain trimerization
metric value
setSize 42
pMANOVA 3.8e-07
p.adjustMANOVA 1.96e-05
s.dist 0.645
s.t -0.483
s.fry -0.428
p.t 6.03e-08
p.fry 1.62e-06




Top 20 genes
Gene t fry
COL7A1 -17106.5 -17188
COL5A1 -17349.5 -16002
COL24A1 -16967.5 -15007
COL11A2 -15464.5 -16292
COL14A1 -16127.5 -15446
COL27A1 -15393.5 -15990
COL16A1 -15018.5 -16184
COL10A1 -17234.5 -13862
COL1A2 -16978.5 -13639
COL17A1 -16822.5 -13130
COL4A4 -13287.5 -16392
COL8A1 -15850.5 -12932
COL1A1 -13691.5 -14825
COL22A1 -12784.5 -15618
COL6A5 -16652.5 -11970
COL18A1 -12084.5 -16273
COL20A1 -11816.5 -16316
COL21A1 -14604.5 -12929
COL12A1 -14837.5 -11384
COL26A1 -12561.5 -12775

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All member genes
t fry
COL10A1 -17234.5 -13862
COL11A1 -7590.5 -13541
COL11A2 -15464.5 -16292
COL12A1 -14837.5 -11384
COL13A1 -9319.5 -10139
COL14A1 -16127.5 -15446
COL15A1 2881.5 2503
COL16A1 -15018.5 -16184
COL17A1 -16822.5 -13130
COL18A1 -12084.5 -16273
COL19A1 -11690.5 -9403
COL1A1 -13691.5 -14825
COL1A2 -16978.5 -13639
COL20A1 -11816.5 -16316
COL21A1 -14604.5 -12929
COL22A1 -12784.5 -15618
COL23A1 -1274.5 532
COL24A1 -16967.5 -15007
COL25A1 -10418.5 -4878
COL26A1 -12561.5 -12775
COL27A1 -15393.5 -15990
COL28A1 -10577.5 -4860
COL2A1 5267.5 6064
COL3A1 -13240.5 -7663
COL4A1 -9692.5 -5428
COL4A2 -13794.5 -9169
COL4A3 -12851.5 -9245
COL4A4 -13287.5 -16392
COL5A1 -17349.5 -16002
COL5A2 -11681.5 -4786
COL5A3 -8085.5 -15414
COL6A1 -4983.5 -12566
COL6A2 -5636.5 -6628
COL6A3 -14319.5 -10336
COL6A5 -16652.5 -11970
COL6A6 -13459.5 -8337
COL7A1 -17106.5 -17188
COL8A1 -15850.5 -12932
COL8A2 -5552.5 -8574
COL9A1 -12799.5 -8215
COL9A2 2107.5 -2852
COL9A3 691.5 826



PINK1-PRKN Mediated Mitophagy

PINK1-PRKN Mediated Mitophagy
metric value
setSize 21
pMANOVA 0.00104
p.adjustMANOVA 0.00974
s.dist 0.603
s.t 0.381
s.fry 0.467
p.t 0.00248
p.fry 0.000213




Top 20 genes
Gene t fry
TOMM40 6829.5 7559
MAP1LC3B 6146.5 6102
PINK1 5853.5 5716
MFN1 4758.5 5542
RPS27A 5587.5 4209
MAP1LC3A 3579.5 3755
MFN2 4075.5 2853
UBB 2867.5 3319
UBA52 2705.5 3161
SQSTM1 2730.5 11

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All member genes
t fry
ATG12 -10540.5 -8892
ATG5 -2298.5 1409
MAP1LC3A 3579.5 3755
MAP1LC3B 6146.5 6102
MFN1 4758.5 5542
MFN2 4075.5 2853
MTERF3 -3340.5 -5206
PARK2 -15592.5 -8323
PINK1 5853.5 5716
RPS27A 5587.5 4209
SQSTM1 2730.5 11
TOMM20 2923.5 -3403
TOMM22 -3606.5 -2646
TOMM40 6829.5 7559
TOMM5 -2929.5 -803
TOMM6 -1055.5 858
TOMM7 -4726.5 4158
UBA52 2705.5 3161
UBB 2867.5 3319
UBC -2334.5 3044
VDAC1 -2882.5 640



POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
metric value
setSize 10
pMANOVA 0.0219
p.adjustMANOVA 0.0939
s.dist 0.603
s.t 0.349
s.fry 0.491
p.t 0.0559
p.fry 0.00713




Top 20 genes
Gene t fry
HHEX 5630.5 6989
DKK1 5771.5 6222
EOMES 4032.5 5157
GSC 1483.5 5109
SOX2 1287.5 5240

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All member genes
t fry
CDX2 -7887.5 -9591
DKK1 5771.5 6222
EOMES 4032.5 5157
GATA6 -3633.5 3084
GSC 1483.5 5109
HHEX 5630.5 6989
NANOG -6691.5 -5367
POU5F1 -3909.5 -2224
SOX2 1287.5 5240
TSC22D1 -811.5 -447



APC/C:Cdc20 mediated degradation of Cyclin B

APC/C:Cdc20 mediated degradation of Cyclin B
metric value
setSize 24
pMANOVA 0.000881
p.adjustMANOVA 0.00879
s.dist 0.596
s.t 0.405
s.fry 0.436
p.t 0.000583
p.fry 0.000216




Top 20 genes
Gene t fry
ANAPC10 7404.5 7859
ANAPC2 5556.5 5436
CCNB1 5370.5 5015
CDC26 4210.5 5928
ANAPC1 5183.5 4706
RPS27A 5587.5 4209
ANAPC16 5075.5 4415
ANAPC7 3145.5 3494
UBB 2867.5 3319
UBA52 2705.5 3161
UBE2D1 3397.5 1550
ANAPC11 1311.5 1682

Click HERE to show all gene set members

All member genes
t fry
ANAPC1 5183.5 4706
ANAPC10 7404.5 7859
ANAPC11 1311.5 1682
ANAPC15 2772.5 -7813
ANAPC16 5075.5 4415
ANAPC2 5556.5 5436
ANAPC4 -4631.5 -6071
ANAPC5 -3242.5 2696
ANAPC7 3145.5 3494
CCNB1 5370.5 5015
CDC16 -612.5 -1905
CDC20 -1087.5 -862
CDC23 -8443.5 -16234
CDC26 4210.5 5928
CDC27 -15945.5 -13845
CDK1 -2491.5 1499
RPS27A 5587.5 4209
UBA52 2705.5 3161
UBB 2867.5 3319
UBC -2334.5 3044
UBE2C -1298.5 -1496
UBE2D1 3397.5 1550
UBE2E1 -3331.5 584
UBE2S -5173.5 6546



TICAM1-dependent activation of IRF3/IRF7

TICAM1-dependent activation of IRF3/IRF7
metric value
setSize 12
pMANOVA 0.0202
p.adjustMANOVA 0.0896
s.dist 0.591
s.t 0.366
s.fry 0.464
p.t 0.0281
p.fry 0.00539




Top 20 genes
Gene t fry
RPS27A 5587.5 4209
IRF7 4161.5 3917
TLR3 1869.5 5644
UBB 2867.5 3319
UBA52 2705.5 3161
TICAM1 1979.5 1183

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All member genes
t fry
IKBKE -6461.5 -11265
IRF3 -1630.5 -2063
IRF7 4161.5 3917
RPS27A 5587.5 4209
TANK -3321.5 1233
TBK1 -5082.5 2802
TICAM1 1979.5 1183
TLR3 1869.5 5644
TRAF3 -3394.5 -2424
UBA52 2705.5 3161
UBB 2867.5 3319
UBC -2334.5 3044



Interaction between L1 and Ankyrins

Interaction between L1 and Ankyrins
metric value
setSize 28
pMANOVA 0.000108
p.adjustMANOVA 0.00179
s.dist 0.583
s.t -0.462
s.fry -0.354
p.t 2.27e-05
p.fry 0.00117




Top 20 genes
Gene t fry
SPTBN2 -16503.5 -17356
SCN10A -17630.5 -15740
SPTBN5 -15770.5 -16689
SCN4A -15882.5 -16337
SCN7A -17357.5 -12629
ANK2 -17797.5 -11993
NRCAM -17213.5 -12392
ANK3 -17808.5 -10429
NFASC -14296.5 -12313
KCNQ2 -11574.5 -15057
SPTAN1 -10921.5 -14709
SCN9A -14532.5 -10623
SCN11A -16116.5 -9344
SCN5A -10447.5 -12963
SCN8A -14854.5 -8801
SCN1B -7794.5 -16664
SCN1A -14258.5 -7342
SPTBN4 -8741.5 -11453
SCN2A -14075.5 -6210
SCN4B -5826.5 -13617

Click HERE to show all gene set members

All member genes
t fry
ANK1 -7098.5 -4849
ANK2 -17797.5 -11993
ANK3 -17808.5 -10429
KCNQ2 -11574.5 -15057
KCNQ3 778.5 566
NFASC -14296.5 -12313
NRCAM -17213.5 -12392
SCN10A -17630.5 -15740
SCN11A -16116.5 -9344
SCN1A -14258.5 -7342
SCN1B -7794.5 -16664
SCN2A -14075.5 -6210
SCN2B -783.5 567
SCN3A -10474.5 -6321
SCN3B 6229.5 7459
SCN4A -15882.5 -16337
SCN4B -5826.5 -13617
SCN5A -10447.5 -12963
SCN7A -17357.5 -12629
SCN8A -14854.5 -8801
SCN9A -14532.5 -10623
SPTA1 -1892.5 550
SPTAN1 -10921.5 -14709
SPTB -7771.5 -7860
SPTBN1 -4743.5 -2059
SPTBN2 -16503.5 -17356
SPTBN4 -8741.5 -11453
SPTBN5 -15770.5 -16689



Class C/3 (Metabotropic glutamate/pheromone receptors)

Class C/3 (Metabotropic glutamate/pheromone receptors)
metric value
setSize 39
pMANOVA 2.15e-07
p.adjustMANOVA 1.34e-05
s.dist 0.568
s.t -0.48
s.fry -0.304
p.t 2.15e-07
p.fry 0.00101




Top 20 genes
Gene t fry
TAS2R4 -17568.5 -15549
TAS2R19 -17774.5 -15058
TAS2R60 -15342.5 -15207
TAS1R1 -13190.5 -17406
GRM1 -14585.5 -15080
TAS2R1 -17229.5 -12533
TAS2R42 -17657.5 -11845
TAS2R20 -16838.5 -12102
GRM6 -12791.5 -15851
GRM8 -16522.5 -12250
GABBR1 -15635.5 -12925
TAS2R39 -16181.5 -11987
TAS2R30 -15688.5 -12180
GRM4 -12980.5 -13977
TAS2R41 -13867.5 -12223
TAS2R3 -14879.5 -11279
TAS2R50 -17428.5 -9483
GRM3 -14609.5 -11141
TAS2R16 -15686.5 -10356
TAS2R8 -16859.5 -9032

Click HERE to show all gene set members

All member genes
t fry
CASR -3016.5 -828
GABBR1 -15635.5 -12925
GABBR2 -8081.5 -7569
GPRC6A -14321.5 -8650
GRM1 -14585.5 -15080
GRM2 1104.5 -636
GRM3 -14609.5 -11141
GRM4 -12980.5 -13977
GRM5 -11830.5 -4725
GRM6 -12791.5 -15851
GRM7 -14954.5 -8490
GRM8 -16522.5 -12250
TAS1R1 -13190.5 -17406
TAS1R2 -1345.5 4216
TAS1R3 5212.5 4088
TAS2R1 -17229.5 -12533
TAS2R10 -12472.5 -8735
TAS2R13 2494.5 2625
TAS2R14 -14187.5 -9713
TAS2R16 -15686.5 -10356
TAS2R19 -17774.5 -15058
TAS2R20 -16838.5 -12102
TAS2R3 -14879.5 -11279
TAS2R30 -15688.5 -12180
TAS2R31 -5312.5 -1431
TAS2R38 -10280.5 -5307
TAS2R39 -16181.5 -11987
TAS2R4 -17568.5 -15549
TAS2R40 1303.5 1078
TAS2R41 -13867.5 -12223
TAS2R42 -17657.5 -11845
TAS2R43 0.5 -16130
TAS2R46 2695.5 -3409
TAS2R5 -9351.5 -6895
TAS2R50 -17428.5 -9483
TAS2R60 -15342.5 -15207
TAS2R7 -13326.5 -6381
TAS2R8 -16859.5 -9032
TAS2R9 -14591.5 -8942



Mitophagy

Mitophagy
metric value
setSize 27
pMANOVA 0.00067
p.adjustMANOVA 0.00677
s.dist 0.564
s.t 0.372
s.fry 0.424
p.t 0.00081
p.fry 0.000137




Top 20 genes
Gene t fry
TOMM40 6829.5 7559
MAP1LC3B 6146.5 6102
PINK1 5853.5 5716
PGAM5 5727.5 5152
MFN1 4758.5 5542
RPS27A 5587.5 4209
MAP1LC3A 3579.5 3755
MFN2 4075.5 2853
UBB 2867.5 3319
UBA52 2705.5 3161
CSNK2A1 2135.5 807
SQSTM1 2730.5 11

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All member genes
t fry
ATG12 -10540.5 -8892
ATG5 -2298.5 1409
CSNK2A1 2135.5 807
CSNK2A2 -3938.5 -747
CSNK2B -8683.5 -12723
MAP1LC3A 3579.5 3755
MAP1LC3B 6146.5 6102
MFN1 4758.5 5542
MFN2 4075.5 2853
MTERF3 -3340.5 -5206
PARK2 -15592.5 -8323
PGAM5 5727.5 5152
PINK1 5853.5 5716
RPS27A 5587.5 4209
SQSTM1 2730.5 11
SRC 2777.5 -1855
TOMM20 2923.5 -3403
TOMM22 -3606.5 -2646
TOMM40 6829.5 7559
TOMM5 -2929.5 -803
TOMM6 -1055.5 858
TOMM7 -4726.5 4158
UBA52 2705.5 3161
UBB 2867.5 3319
UBC -2334.5 3044
ULK1 -1549.5 1047
VDAC1 -2882.5 640



Interaction With Cumulus Cells And The Zona Pellucida

Interaction With Cumulus Cells And The Zona Pellucida
metric value
setSize 11
pMANOVA 0.0338
p.adjustMANOVA 0.126
s.dist 0.562
s.t -0.448
s.fry -0.34
p.t 0.01
p.fry 0.051




Top 20 genes
Gene t fry
ADAM2 -17184.5 -16027
ZP4 -17487.5 -14499
ZP1 -14292.5 -17322
ADAM21 -16144.5 -14272
OVGP1 -14117.5 -10849
ZP3 -8138.5 -11013
SPAM1 -10857.5 -7904
ADAM20 -11672.5 -5362
ZP2 -10479.5 -4997
ADAM30 -3221.5 -4585

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All member genes
t fry
ADAM2 -17184.5 -16027
ADAM20 -11672.5 -5362
ADAM21 -16144.5 -14272
ADAM30 -3221.5 -4585
B4GALT1 5676.5 4906
OVGP1 -14117.5 -10849
SPAM1 -10857.5 -7904
ZP1 -14292.5 -17322
ZP2 -10479.5 -4997
ZP3 -8138.5 -11013
ZP4 -17487.5 -14499



Bicarbonate transporters

Bicarbonate transporters
metric value
setSize 10
pMANOVA 0.0526
p.adjustMANOVA 0.172
s.dist 0.561
s.t -0.441
s.fry -0.347
p.t 0.0157
p.fry 0.0573




Top 20 genes
Gene t fry
SLC4A3 -14479.5 -17412
SLC4A5 -17317.5 -14307
SLC4A7 -13993.5 -10892
SLC4A8 -13868.5 -10688
SLC4A10 -12724.5 -7242
SLC4A9 -7750.5 -10162
SLC4A4 -12009.5 -5761
SLC4A2 -4560.5 -13424
AHCYL2 -8794.5 -4093

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All member genes
t fry
AHCYL2 -8794.5 -4093
SLC4A1 -797.5 377
SLC4A10 -12724.5 -7242
SLC4A2 -4560.5 -13424
SLC4A3 -14479.5 -17412
SLC4A4 -12009.5 -5761
SLC4A5 -17317.5 -14307
SLC4A7 -13993.5 -10892
SLC4A8 -13868.5 -10688
SLC4A9 -7750.5 -10162



Aberrant regulation of mitotic cell cycle due to RB1 defects

Aberrant regulation of mitotic cell cycle due to RB1 defects
metric value
setSize 36
pMANOVA 0.000102
p.adjustMANOVA 0.00171
s.dist 0.553
s.t 0.41
s.fry 0.371
p.t 2.08e-05
p.fry 0.000116




Top 20 genes
Gene t fry
ANAPC10 7404.5 7859
CCNE2 6602.5 7552
CDKN1A 6427.5 7339
FZR1 6912.5 6379
ANAPC2 5556.5 5436
CDK4 5020.5 5193
CDC26 4210.5 5928
ANAPC1 5183.5 4706
ANAPC16 5075.5 4415
E2F2 3693.5 5091
CDKN1C 3853.5 3215
ANAPC7 3145.5 3494
TFDP1 4196.5 1471
SKP2 3089.5 1993
UBE2D1 3397.5 1550
ANAPC11 1311.5 1682
CDKN1B 1232.5 150

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All member genes
t fry
ANAPC1 5183.5 4706
ANAPC10 7404.5 7859
ANAPC11 1311.5 1682
ANAPC15 2772.5 -7813
ANAPC16 5075.5 4415
ANAPC2 5556.5 5436
ANAPC4 -4631.5 -6071
ANAPC5 -3242.5 2696
ANAPC7 3145.5 3494
CCND1 -558.5 1828
CCND2 -1771.5 -12869
CCND3 -3881.5 -13312
CCNE1 1477.5 -4535
CCNE2 6602.5 7552
CDC16 -612.5 -1905
CDC23 -8443.5 -16234
CDC26 4210.5 5928
CDC27 -15945.5 -13845
CDK2 -2387.5 -1542
CDK4 5020.5 5193
CDK6 -7556.5 -2452
CDKN1A 6427.5 7339
CDKN1B 1232.5 150
CDKN1C 3853.5 3215
E2F1 1280.5 -941
E2F2 3693.5 5091
E2F3 -1852.5 -2253
FZR1 6912.5 6379
RB1 -6144.5 -2462
SKP2 3089.5 1993
TFDP1 4196.5 1471
TFDP2 -4110.5 -2170
UBE2C -1298.5 -1496
UBE2D1 3397.5 1550
UBE2E1 -3331.5 584
UBE2S -5173.5 6546



Aberrant regulation of mitotic exit in cancer due to RB1 defects

Aberrant regulation of mitotic exit in cancer due to RB1 defects
metric value
setSize 20
pMANOVA 0.00714
p.adjustMANOVA 0.0428
s.dist 0.55
s.t 0.383
s.fry 0.395
p.t 0.00302
p.fry 0.00224




Top 20 genes
Gene t fry
ANAPC10 7404.5 7859
FZR1 6912.5 6379
ANAPC2 5556.5 5436
CDC26 4210.5 5928
ANAPC1 5183.5 4706
ANAPC16 5075.5 4415
ANAPC7 3145.5 3494
SKP2 3089.5 1993
UBE2D1 3397.5 1550
ANAPC11 1311.5 1682

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All member genes
t fry
ANAPC1 5183.5 4706
ANAPC10 7404.5 7859
ANAPC11 1311.5 1682
ANAPC15 2772.5 -7813
ANAPC16 5075.5 4415
ANAPC2 5556.5 5436
ANAPC4 -4631.5 -6071
ANAPC5 -3242.5 2696
ANAPC7 3145.5 3494
CDC16 -612.5 -1905
CDC23 -8443.5 -16234
CDC26 4210.5 5928
CDC27 -15945.5 -13845
FZR1 6912.5 6379
RB1 -6144.5 -2462
SKP2 3089.5 1993
UBE2C -1298.5 -1496
UBE2D1 3397.5 1550
UBE2E1 -3331.5 584
UBE2S -5173.5 6546



Translation of Replicase and Assembly of the Replication Transcription Complex_9694676

Translation of Replicase and Assembly of the Replication Transcription Complex_9694676
metric value
setSize 14
pMANOVA 0.018
p.adjustMANOVA 0.083
s.dist 0.55
s.t 0.337
s.fry 0.435
p.t 0.0291
p.fry 0.00487




Top 20 genes
Gene t fry
BECN1 7707.5 7886
CHMP4A 7063.5 7773
CHMP4B 7097.5 7353
ISCU 7130.5 7248
CHMP2A 5881.5 6863
MAP1LC3B 6146.5 6102
PIK3R4 2953.5 1553

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All member genes
t fry
BECN1 7707.5 7886
CHMP2A 5881.5 6863
CHMP2B -13395.5 -14401
CHMP3 -6148.5 -3686
CHMP4A 7063.5 7773
CHMP4B 7097.5 7353
CHMP4C -6292.5 -2768
CHMP6 -957.5 -2021
CHMP7 -1629.5 758
ISCU 7130.5 7248
MAP1LC3B 6146.5 6102
PIK3C3 -8780.5 -7455
PIK3R4 2953.5 1553
UVRAG -15598.5 -5596



Phosphorylation of the APC/C

Phosphorylation of the APC/C
metric value
setSize 20
pMANOVA 0.0069
p.adjustMANOVA 0.0421
s.dist 0.55
s.t 0.377
s.fry 0.4
p.t 0.00353
p.fry 0.00193




Top 20 genes
Gene t fry
ANAPC10 7404.5 7859
ANAPC2 5556.5 5436
CCNB1 5370.5 5015
CDC26 4210.5 5928
ANAPC1 5183.5 4706
ANAPC16 5075.5 4415
ANAPC7 3145.5 3494
UBE2D1 3397.5 1550
ANAPC11 1311.5 1682

Click HERE to show all gene set members

All member genes
t fry
ANAPC1 5183.5 4706
ANAPC10 7404.5 7859
ANAPC11 1311.5 1682
ANAPC15 2772.5 -7813
ANAPC16 5075.5 4415
ANAPC2 5556.5 5436
ANAPC4 -4631.5 -6071
ANAPC5 -3242.5 2696
ANAPC7 3145.5 3494
CCNB1 5370.5 5015
CDC16 -612.5 -1905
CDC23 -8443.5 -16234
CDC26 4210.5 5928
CDC27 -15945.5 -13845
CDK1 -2491.5 1499
PLK1 -619.5 877
UBE2C -1298.5 -1496
UBE2D1 3397.5 1550
UBE2E1 -3331.5 584
UBE2S -5173.5 6546



Mitochondrial iron-sulfur cluster biogenesis

Mitochondrial iron-sulfur cluster biogenesis
metric value
setSize 12
pMANOVA 0.0482
p.adjustMANOVA 0.163
s.dist 0.549
s.t 0.368
s.fry 0.408
p.t 0.0275
p.fry 0.0144




Top 20 genes
Gene t fry
ISCU 7130.5 7248
SLC25A37 7168.5 5585
HSCB 6198.5 6137
SLC25A28 5575.5 6219
FDX1 692.5 2475

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All member genes
t fry
FDX1 692.5 2475
FDXR -2274.5 -434
FXN 832.5 -4686
GLRX5 -2962.5 3981
HSCB 6198.5 6137
ISCA1 2609.5 -1230
ISCA2 -15593.5 -17450
ISCU 7130.5 7248
LYRM4 -9144.5 -5850
NFS1 -3055.5 2138
SLC25A28 5575.5 6219
SLC25A37 7168.5 5585



Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes
metric value
setSize 11
pMANOVA 0.0652
p.adjustMANOVA 0.195
s.dist 0.547
s.t 0.371
s.fry 0.402
p.t 0.0333
p.fry 0.0208




Top 20 genes
Gene t fry
SMC2 7138.5 6068
NCAPG 5361.5 6164
CCNB1 5370.5 5015
CCNB2 1940.5 2528
CSNK2A1 2135.5 807

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All member genes
t fry
CCNB1 5370.5 5015
CCNB2 1940.5 2528
CDK1 -2491.5 1499
CSNK2A1 2135.5 807
CSNK2A2 -3938.5 -747
CSNK2B -8683.5 -12723
NCAPD2 -1915.5 -5230
NCAPG 5361.5 6164
NCAPH -3814.5 -3583
SMC2 7138.5 6068
SMC4 -3257.5 3199



Digestion

Digestion
metric value
setSize 18
pMANOVA 0.001
p.adjustMANOVA 0.00955
s.dist 0.546
s.t -0.466
s.fry -0.285
p.t 0.000612
p.fry 0.0366




Top 20 genes
Gene t fry
ALPI -17048.5 -17339
LIPF -17741.5 -14463
TREH -16026.5 -15930
PNLIPRP3 -17335.5 -13817
GUCA2B -11453.5 -14921
AMY2A -13944.5 -10874
PNLIPRP1 -15135.5 -9996
CEL -11144.5 -13138
LCT -11846.5 -10095
PNLIP -13242.5 -6425
CHIA -14875.5 -5488
GUCY2C -9958.5 -6962
CLPS -8476.5 -7623
AMY2B -9694.5 -6217
PNLIPRP2 -7305.5 -6803
MGAM -3099.5 -1700

Click HERE to show all gene set members

All member genes
t fry
ALPI -17048.5 -17339
AMY2A -13944.5 -10874
AMY2B -9694.5 -6217
CEL -11144.5 -13138
CHIA -14875.5 -5488
CHIT1 -2673.5 4481
CLPS -8476.5 -7623
GUCA2A 3877.5 3335
GUCA2B -11453.5 -14921
GUCY2C -9958.5 -6962
LCT -11846.5 -10095
LIPF -17741.5 -14463
MGAM -3099.5 -1700
PNLIP -13242.5 -6425
PNLIPRP1 -15135.5 -9996
PNLIPRP2 -7305.5 -6803
PNLIPRP3 -17335.5 -13817
TREH -16026.5 -15930



STAT5 activation downstream of FLT3 ITD mutants

STAT5 activation downstream of FLT3 ITD mutants
metric value
setSize 10
pMANOVA 0.07
p.adjustMANOVA 0.202
s.dist 0.544
s.t 0.344
s.fry 0.421
p.t 0.0592
p.fry 0.0212




Top 20 genes
Gene t fry
CDKN1A 6427.5 7339
PIM1 5773.5 6686
STAT5A 5253.5 5724
PTPN11 4193.5 4899
FLT3 2849.5 1997

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All member genes
t fry
BCL2L1 -1822.5 -1882
CDKN1A 6427.5 7339
FLT3 2849.5 1997
GAB2 -7856.5 -2695
GRB2 1347.5 -2276
NOX4 -12973.5 -9537
PIM1 5773.5 6686
PTPN11 4193.5 4899
STAT5A 5253.5 5724
STAT5B -8504.5 -5144



Constitutive Signaling by Overexpressed ERBB2

Constitutive Signaling by Overexpressed ERBB2
metric value
setSize 10
pMANOVA 0.0903
p.adjustMANOVA 0.237
s.dist 0.542
s.t 0.378
s.fry 0.389
p.t 0.0384
p.fry 0.0332




Top 20 genes
Gene t fry
SHC1 7251.5 7410
KRAS 3298.5 5530
NRAS 3775.5 3362
ERBB2 3914.5 2805
CDC37 2145.5 968

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All member genes
t fry
CDC37 2145.5 968
ERBB2 3914.5 2805
GRB2 1347.5 -2276
HRAS -9219.5 -14411
HSP90AA1 -3202.5 3731
KRAS 3298.5 5530
NRAS 3775.5 3362
PTPN12 -4771.5 -4019
SHC1 7251.5 7410
SOS1 -5527.5 -2091



Prednisone ADME

Prednisone ADME
metric value
setSize 10
pMANOVA 0.00988
p.adjustMANOVA 0.0542
s.dist 0.542
s.t -0.48
s.fry -0.251
p.t 0.00858
p.fry 0.169




Top 20 genes
Gene t fry
SERPINA6 -17286.5 -15969
UGT2B7 -16765.5 -13049
ALB -17546.5 -10083
ABCB1 -14932.5 -10132
UGT1A3 -12195.5 -9969
CYP3A4 -9139.5 -6979
HSD11B2 -6472.5 -9528
AKR1C1 -7754.5 -3233
HSD11B1 -6079.5 -2754

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All member genes
t fry
ABCB1 -14932.5 -10132
AKR1C1 -7754.5 -3233
ALB -17546.5 -10083
CYP3A4 -9139.5 -6979
HSD11B1 -6079.5 -2754
HSD11B2 -6472.5 -9528
SERPINA6 -17286.5 -15969
UGT1A3 -12195.5 -9969
UGT2B17 -3103.5 444
UGT2B7 -16765.5 -13049



Regulation of commissural axon pathfinding by SLIT and ROBO

Regulation of commissural axon pathfinding by SLIT and ROBO
metric value
setSize 10
pMANOVA 0.0534
p.adjustMANOVA 0.174
s.dist 0.536
s.t -0.433
s.fry -0.316
p.t 0.0176
p.fry 0.0834




Top 20 genes
Gene t fry
NELL2 -14039.5 -11728
ROBO2 -16635.5 -9854
NTN1 -11452.5 -13036
SLIT3 -15561.5 -9244
ROBO1 -15033.5 -7573
ROBO3 -7079.5 -14927
DCC -10930.5 -9450
SLIT1 -6666.5 -7556
SLIT2 -10670.5 -4396

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All member genes
t fry
DCC -10930.5 -9450
NELL2 -14039.5 -11728
NTN1 -11452.5 -13036
ROBO1 -15033.5 -7573
ROBO2 -16635.5 -9854
ROBO3 -7079.5 -14927
SLIT1 -6666.5 -7556
SLIT2 -10670.5 -4396
SLIT3 -15561.5 -9244
SRC 2777.5 -1855



Androgen biosynthesis

Androgen biosynthesis
metric value
setSize 11
pMANOVA 0.0772
p.adjustMANOVA 0.215
s.dist 0.531
s.t -0.388
s.fry -0.363
p.t 0.0258
p.fry 0.0373




Top 20 genes
Gene t fry
SRD5A2 -15321.5 -16459
HSD3B2 -17638.5 -13991
CYP17A1 -14380.5 -16245
HSD17B3 -14580.5 -13035
SRD5A3 -13146.5 -13081
SRD5A1 -11423.5 -14846
HSD3B1 -8984.5 -5695
HSD17B12 -8923.5 -5107
CGA -9288.5 -3669

Click HERE to show all gene set members

All member genes
t fry
CGA -9288.5 -3669
CYP17A1 -14380.5 -16245
HSD17B12 -8923.5 -5107
HSD17B3 -14580.5 -13035
HSD3B1 -8984.5 -5695
HSD3B2 -17638.5 -13991
LHB 2776.5 -308
POMC 1475.5 -2700
SRD5A1 -11423.5 -14846
SRD5A2 -15321.5 -16459
SRD5A3 -13146.5 -13081



Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects

Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
metric value
setSize 17
pMANOVA 0.0133
p.adjustMANOVA 0.0672
s.dist 0.529
s.t 0.411
s.fry 0.332
p.t 0.00333
p.fry 0.0177




Top 20 genes
Gene t fry
CCNE2 6602.5 7552
CDKN1A 6427.5 7339
CDK4 5020.5 5193
E2F2 3693.5 5091
CDKN1C 3853.5 3215
TFDP1 4196.5 1471
CDKN1B 1232.5 150

Click HERE to show all gene set members

All member genes
t fry
CCND1 -558.5 1828
CCND2 -1771.5 -12869
CCND3 -3881.5 -13312
CCNE1 1477.5 -4535
CCNE2 6602.5 7552
CDK2 -2387.5 -1542
CDK4 5020.5 5193
CDK6 -7556.5 -2452
CDKN1A 6427.5 7339
CDKN1B 1232.5 150
CDKN1C 3853.5 3215
E2F1 1280.5 -941
E2F2 3693.5 5091
E2F3 -1852.5 -2253
RB1 -6144.5 -2462
TFDP1 4196.5 1471
TFDP2 -4110.5 -2170



Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)

Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
metric value
setSize 17
pMANOVA 0.0133
p.adjustMANOVA 0.0672
s.dist 0.529
s.t 0.411
s.fry 0.332
p.t 0.00333
p.fry 0.0177




Top 20 genes
Gene t fry
CCNE2 6602.5 7552
CDKN1A 6427.5 7339
CDK4 5020.5 5193
E2F2 3693.5 5091
CDKN1C 3853.5 3215
TFDP1 4196.5 1471
CDKN1B 1232.5 150

Click HERE to show all gene set members

All member genes
t fry
CCND1 -558.5 1828
CCND2 -1771.5 -12869
CCND3 -3881.5 -13312
CCNE1 1477.5 -4535
CCNE2 6602.5 7552
CDK2 -2387.5 -1542
CDK4 5020.5 5193
CDK6 -7556.5 -2452
CDKN1A 6427.5 7339
CDKN1B 1232.5 150
CDKN1C 3853.5 3215
E2F1 1280.5 -941
E2F2 3693.5 5091
E2F3 -1852.5 -2253
RB1 -6144.5 -2462
TFDP1 4196.5 1471
TFDP2 -4110.5 -2170



Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
metric value
setSize 20
pMANOVA 0.0111
p.adjustMANOVA 0.0593
s.dist 0.525
s.t 0.367
s.fry 0.376
p.t 0.0045
p.fry 0.00361




Top 20 genes
Gene t fry
ANAPC10 7404.5 7859
FZR1 6912.5 6379
ANAPC2 5556.5 5436
CDC26 4210.5 5928
ANAPC1 5183.5 4706
ANAPC16 5075.5 4415
ANAPC7 3145.5 3494
UBE2D1 3397.5 1550
ANAPC11 1311.5 1682

Click HERE to show all gene set members

All member genes
t fry
ANAPC1 5183.5 4706
ANAPC10 7404.5 7859
ANAPC11 1311.5 1682
ANAPC15 2772.5 -7813
ANAPC16 5075.5 4415
ANAPC2 5556.5 5436
ANAPC4 -4631.5 -6071
ANAPC5 -3242.5 2696
ANAPC7 3145.5 3494
CDC14A -6110.5 -4429
CDC16 -612.5 -1905
CDC20 -1087.5 -862
CDC23 -8443.5 -16234
CDC26 4210.5 5928
CDC27 -15945.5 -13845
FZR1 6912.5 6379
UBE2C -1298.5 -1496
UBE2D1 3397.5 1550
UBE2E1 -3331.5 584
UBE2S -5173.5 6546



Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
metric value
setSize 17
pMANOVA 0.0199
p.adjustMANOVA 0.0888
s.dist 0.523
s.t 0.347
s.fry 0.39
p.t 0.0131
p.fry 0.00532




Top 20 genes
Gene t fry
TLR4 6597.5 5059
RPS27A 5587.5 4209
PTPN11 4193.5 4899
SARM1 4907.5 4137
IRF7 4161.5 3917
UBB 2867.5 3319
UBA52 2705.5 3161
TICAM1 1979.5 1183
CD14 655.5 683

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All member genes
t fry
CD14 655.5 683
IKBKE -6461.5 -11265
IRF3 -1630.5 -2063
IRF7 4161.5 3917
LY96 -11291.5 -13889
PTPN11 4193.5 4899
RPS27A 5587.5 4209
SARM1 4907.5 4137
TANK -3321.5 1233
TBK1 -5082.5 2802
TICAM1 1979.5 1183
TICAM2 -8561.5 -5998
TLR4 6597.5 5059
TRAF3 -3394.5 -2424
UBA52 2705.5 3161
UBB 2867.5 3319
UBC -2334.5 3044



APC-Cdc20 mediated degradation of Nek2A

APC-Cdc20 mediated degradation of Nek2A
metric value
setSize 26
pMANOVA 0.0031
p.adjustMANOVA 0.0235
s.dist 0.518
s.t 0.351
s.fry 0.381
p.t 0.00193
p.fry 0.000782




Top 20 genes
Gene t fry
ANAPC10 7404.5 7859
ANAPC2 5556.5 5436
CDC26 4210.5 5928
ANAPC1 5183.5 4706
RPS27A 5587.5 4209
ANAPC16 5075.5 4415
BUB3 3407.5 3569
ANAPC7 3145.5 3494
UBB 2867.5 3319
UBA52 2705.5 3161
UBE2D1 3397.5 1550
ANAPC11 1311.5 1682

Click HERE to show all gene set members

All member genes
t fry
ANAPC1 5183.5 4706
ANAPC10 7404.5 7859
ANAPC11 1311.5 1682
ANAPC15 2772.5 -7813
ANAPC16 5075.5 4415
ANAPC2 5556.5 5436
ANAPC4 -4631.5 -6071
ANAPC5 -3242.5 2696
ANAPC7 3145.5 3494
BUB1B -3303.5 1067
BUB3 3407.5 3569
CDC16 -612.5 -1905
CDC20 -1087.5 -862
CDC23 -8443.5 -16234
CDC26 4210.5 5928
CDC27 -15945.5 -13845
MAD2L1 -10234.5 -14191
NEK2 -4601.5 -1127
RPS27A 5587.5 4209
UBA52 2705.5 3161
UBB 2867.5 3319
UBC -2334.5 3044
UBE2C -1298.5 -1496
UBE2D1 3397.5 1550
UBE2E1 -3331.5 584
UBE2S -5173.5 6546



Defective C1GALT1C1 causes TNPS

Defective C1GALT1C1 causes TNPS
metric value
setSize 18
pMANOVA 0.019
p.adjustMANOVA 0.086
s.dist 0.514
s.t -0.38
s.fry -0.347
p.t 0.00529
p.fry 0.0108




Top 20 genes
Gene t fry
MUC17 -16716.5 -17705
MUC7 -17598.5 -14454
MUC12 -14357.5 -17621
MUC15 -16269.5 -13616
MUC2 -13555.5 -15644
MUC5B -13033.5 -15551
C1GALT1 -16211.5 -11150
MUC4 -10364.5 -13278
MUCL1 -13010.5 -10240
MUC19 -14770.5 -7241
MUC21 -12162.5 -8231
MUC13 -11989.5 -5945
MUC6 -5999.5 -7394
MUC5AC -6996.5 -5081
MUC20 -4150.5 -2441

Click HERE to show all gene set members

All member genes
t fry
C1GALT1 -16211.5 -11150
MUC1 4092.5 2926
MUC12 -14357.5 -17621
MUC13 -11989.5 -5945
MUC15 -16269.5 -13616
MUC16 1765.5 -133
MUC17 -16716.5 -17705
MUC19 -14770.5 -7241
MUC2 -13555.5 -15644
MUC20 -4150.5 -2441
MUC21 -12162.5 -8231
MUC3A 4273.5 -5607
MUC4 -10364.5 -13278
MUC5AC -6996.5 -5081
MUC5B -13033.5 -15551
MUC6 -5999.5 -7394
MUC7 -17598.5 -14454
MUCL1 -13010.5 -10240



Diseases of mitotic cell cycle

Diseases of mitotic cell cycle
metric value
setSize 37
pMANOVA 0.000297
p.adjustMANOVA 0.0035
s.dist 0.509
s.t 0.382
s.fry 0.337
p.t 5.88e-05
p.fry 0.000391




Top 20 genes
Gene t fry
ANAPC10 7404.5 7859
CCNE2 6602.5 7552
CDKN1A 6427.5 7339
FZR1 6912.5 6379
ANAPC2 5556.5 5436
CDK4 5020.5 5193
CDC26 4210.5 5928
ANAPC1 5183.5 4706
ANAPC16 5075.5 4415
E2F2 3693.5 5091
CDKN1C 3853.5 3215
ANAPC7 3145.5 3494
TFDP1 4196.5 1471
SKP2 3089.5 1993
UBE2D1 3397.5 1550
ANAPC11 1311.5 1682
CDKN1B 1232.5 150

Click HERE to show all gene set members

All member genes
t fry
ANAPC1 5183.5 4706
ANAPC10 7404.5 7859
ANAPC11 1311.5 1682
ANAPC15 2772.5 -7813
ANAPC16 5075.5 4415
ANAPC2 5556.5 5436
ANAPC4 -4631.5 -6071
ANAPC5 -3242.5 2696
ANAPC7 3145.5 3494
CCND1 -558.5 1828
CCND2 -1771.5 -12869
CCND3 -3881.5 -13312
CCNE1 1477.5 -4535
CCNE2 6602.5 7552
CDC16 -612.5 -1905
CDC23 -8443.5 -16234
CDC26 4210.5 5928
CDC27 -15945.5 -13845
CDK2 -2387.5 -1542
CDK4 5020.5 5193
CDK6 -7556.5 -2452
CDKN1A 6427.5 7339
CDKN1B 1232.5 150
CDKN1C 3853.5 3215
DAXX -13125.5 -16465
E2F1 1280.5 -941
E2F2 3693.5 5091
E2F3 -1852.5 -2253
FZR1 6912.5 6379
RB1 -6144.5 -2462
SKP2 3089.5 1993
TFDP1 4196.5 1471
TFDP2 -4110.5 -2170
UBE2C -1298.5 -1496
UBE2D1 3397.5 1550
UBE2E1 -3331.5 584
UBE2S -5173.5 6546



Collagen biosynthesis and modifying enzymes

Collagen biosynthesis and modifying enzymes
metric value
setSize 65
pMANOVA 5.97e-07
p.adjustMANOVA 2.8e-05
s.dist 0.509
s.t -0.383
s.fry -0.335
p.t 9.17e-08
p.fry 3e-06




Top 20 genes
Gene t fry
COL7A1 -17106.5 -17188
ADAMTS2 -17671.5 -15943
COL5A1 -17349.5 -16002
COL24A1 -16967.5 -15007
COL11A2 -15464.5 -16292
COL14A1 -16127.5 -15446
COL27A1 -15393.5 -15990
COL16A1 -15018.5 -16184
COL10A1 -17234.5 -13862
PLOD2 -17019.5 -13778
COL1A2 -16978.5 -13639
COL17A1 -16822.5 -13130
COL4A4 -13287.5 -16392
COL8A1 -15850.5 -12932
COL1A1 -13691.5 -14825
COL22A1 -12784.5 -15618
COL6A5 -16652.5 -11970
COL18A1 -12084.5 -16273
BMP1 -12533.5 -15474
COL20A1 -11816.5 -16316

Click HERE to show all gene set members

All member genes
t fry
ADAMTS14 -7531.5 -7750
ADAMTS2 -17671.5 -15943
ADAMTS3 -13374.5 -8463
BMP1 -12533.5 -15474
COL10A1 -17234.5 -13862
COL11A1 -7590.5 -13541
COL11A2 -15464.5 -16292
COL12A1 -14837.5 -11384
COL13A1 -9319.5 -10139
COL14A1 -16127.5 -15446
COL15A1 2881.5 2503
COL16A1 -15018.5 -16184
COL17A1 -16822.5 -13130
COL18A1 -12084.5 -16273
COL19A1 -11690.5 -9403
COL1A1 -13691.5 -14825
COL1A2 -16978.5 -13639
COL20A1 -11816.5 -16316
COL21A1 -14604.5 -12929
COL22A1 -12784.5 -15618
COL23A1 -1274.5 532
COL24A1 -16967.5 -15007
COL25A1 -10418.5 -4878
COL26A1 -12561.5 -12775
COL27A1 -15393.5 -15990
COL28A1 -10577.5 -4860
COL2A1 5267.5 6064
COL3A1 -13240.5 -7663
COL4A1 -9692.5 -5428
COL4A2 -13794.5 -9169
COL4A3 -12851.5 -9245
COL4A4 -13287.5 -16392
COL5A1 -17349.5 -16002
COL5A2 -11681.5 -4786
COL5A3 -8085.5 -15414
COL6A1 -4983.5 -12566
COL6A2 -5636.5 -6628
COL6A3 -14319.5 -10336
COL6A5 -16652.5 -11970
COL6A6 -13459.5 -8337
COL7A1 -17106.5 -17188
COL8A1 -15850.5 -12932
COL8A2 -5552.5 -8574
COL9A1 -12799.5 -8215
COL9A2 2107.5 -2852
COL9A3 691.5 826
COLGALT1 -8956.5 -7718
COLGALT2 -15000.5 -8159
CRTAP -5457.5 -11146
P3H1 2848.5 1421
P3H2 -14086.5 -5466
P3H3 -7800.5 -10966
P4HA1 -1224.5 -850
P4HA2 -13292.5 -12772
P4HA3 -7101.5 -5202
P4HB 7794.5 7522
PCOLCE -10648.5 -14195
PCOLCE2 -3992.5 -5784
PLOD1 -3250.5 -1755
PLOD2 -17019.5 -13778
PLOD3 -9182.5 -12166
PPIB 7175.5 7551
SERPINH1 -13884.5 -12582
TLL1 -9761.5 -8228
TLL2 1011.5 603



Synthesis of active ubiquitin: roles of E1 and E2 enzymes

Synthesis of active ubiquitin: roles of E1 and E2 enzymes
metric value
setSize 27
pMANOVA 0.000257
p.adjustMANOVA 0.00316
s.dist 0.506
s.t 0.274
s.fry 0.425
p.t 0.0137
p.fry 0.000129




Top 20 genes
Gene t fry
UBE2B 6809.5 7153
UBE2T 6636.5 7183
RPS27A 5587.5 4209
UBE2W 5444.5 4035
UBE2Q2 3430.5 6180
UBE2G2 3024.5 3888
UBB 2867.5 3319
UBA52 2705.5 3161
UBE2D1 3397.5 1550
UBE2Z 786.5 3121
UBE2G1 2411.5 459

Click HERE to show all gene set members

All member genes
t fry
CDC34 -851.5 -1989
OTULIN -10159.5 -11159
RPS27A 5587.5 4209
UBA52 2705.5 3161
UBA6 689.5 -498
UBB 2867.5 3319
UBC -2334.5 3044
UBE2B 6809.5 7153
UBE2C -1298.5 -1496
UBE2D1 3397.5 1550
UBE2D2 -5904.5 4182
UBE2E1 -3331.5 584
UBE2E3 -7874.5 -3034
UBE2G1 2411.5 459
UBE2G2 3024.5 3888
UBE2H -13607.5 -7641
UBE2K -14537.5 -15206
UBE2L3 -1800.5 1560
UBE2Q2 3430.5 6180
UBE2R2 3636.5 -2531
UBE2S -5173.5 6546
UBE2T 6636.5 7183
UBE2W 5444.5 4035
UBE2Z 786.5 3121
UCHL3 -7759.5 3841
USP5 -2555.5 3108
USP7 -9123.5 -8271



Assembly Of The HIV Virion

Assembly Of The HIV Virion
metric value
setSize 16
pMANOVA 0.00737
p.adjustMANOVA 0.0435
s.dist 0.505
s.t 0.273
s.fry 0.425
p.t 0.0587
p.fry 0.00321




Top 20 genes
Gene t fry
MVB12A 7528.5 5520
PPIA 6042.5 6418
TSG101 4555.5 5575
RPS27A 5587.5 4209
UBB 2867.5 3319
UBA52 2705.5 3161

Click HERE to show all gene set members

All member genes
t fry
FURIN -5708.5 -3645
MVB12A 7528.5 5520
MVB12B -11819.5 -9963
NMT2 -11606.5 -11592
PPIA 6042.5 6418
RPS27A 5587.5 4209
TSG101 4555.5 5575
UBA52 2705.5 3161
UBAP1 -9026.5 -6073
UBB 2867.5 3319
UBC -2334.5 3044
VPS28 -4520.5 3578
VPS37A -539.5 -705
VPS37B -2249.5 2343
VPS37C -1951.5 -622
VPS37D -2754.5 4520



Adherens junctions interactions

Adherens junctions interactions
metric value
setSize 26
pMANOVA 8.5e-05
p.adjustMANOVA 0.00149
s.dist 0.505
s.t -0.439
s.fry -0.25
p.t 0.000105
p.fry 0.0274




Top 20 genes
Gene t fry
CDH17 -17724.5 -15723
CDH4 -16721.5 -15213
CDH18 -17784.5 -12195
CADM1 -17627.5 -11760
CDH3 -13314.5 -14162
CDH2 -15648.5 -10925
CDH6 -16128.5 -10359
CTNNA1 -16734.5 -8786
CDH7 -12903.5 -11388
CDH15 -8803.5 -14069
CDH13 -14142.5 -8489
CDH24 -11370.5 -10477
CDH8 -13429.5 -7886
PVR -9472.5 -7820
CADM3 -7159.5 -8996
CDH12 -9889.5 -6296
CDH5 -11678.5 -5223
CTNNB1 -10128.5 -5280
CDH10 -8483.5 -4490
CDH9 -7964.5 -4525

Click HERE to show all gene set members

All member genes
t fry
ANG 5257.5 4921
CADM1 -17627.5 -11760
CADM2 -8050.5 -3593
CADM3 -7159.5 -8996
CDH1 -4388.5 -3711
CDH10 -8483.5 -4490
CDH11 -7285.5 -4800
CDH12 -9889.5 -6296
CDH13 -14142.5 -8489
CDH15 -8803.5 -14069
CDH17 -17724.5 -15723
CDH18 -17784.5 -12195
CDH2 -15648.5 -10925
CDH24 -11370.5 -10477
CDH3 -13314.5 -14162
CDH4 -16721.5 -15213
CDH5 -11678.5 -5223
CDH6 -16128.5 -10359
CDH7 -12903.5 -11388
CDH8 -13429.5 -7886
CDH9 -7964.5 -4525
CTNNA1 -16734.5 -8786
CTNNB1 -10128.5 -5280
CTNND1 -5885.5 -5956
JUP 1811.5 -3622
PVR -9472.5 -7820



TICAM1, RIP1-mediated IKK complex recruitment

TICAM1, RIP1-mediated IKK complex recruitment
metric value
setSize 18
pMANOVA 0.0236
p.adjustMANOVA 0.0986
s.dist 0.505
s.t 0.357
s.fry 0.358
p.t 0.00872
p.fry 0.0086




Top 20 genes
Gene t fry
UBE2V1 6049.5 6803
RIPK3 7061.5 5791
RPS27A 5587.5 4209
TLR3 1869.5 5644
UBB 2867.5 3319
BIRC3 1785.5 5094
UBA52 2705.5 3161
UBE2D1 3397.5 1550
TICAM1 1979.5 1183

Click HERE to show all gene set members

All member genes
t fry
BIRC2 -1179.5 -244
BIRC3 1785.5 5094
CHUK -8230.5 -3866
IKBKB -14161.5 -12870
RIPK1 -6856.5 -3890
RIPK3 7061.5 5791
RPS27A 5587.5 4209
TICAM1 1979.5 1183
TLR3 1869.5 5644
TRAF6 2291.5 -10279
UBA52 2705.5 3161
UBB 2867.5 3319
UBC -2334.5 3044
UBE2D1 3397.5 1550
UBE2D2 -5904.5 4182
UBE2D3 4222.5 -8583
UBE2N -7838.5 -9698
UBE2V1 6049.5 6803



Cleavage of the damaged pyrimidine

Cleavage of the damaged pyrimidine
metric value
setSize 16
pMANOVA 0.0333
p.adjustMANOVA 0.125
s.dist 0.504
s.t 0.338
s.fry 0.374
p.t 0.0192
p.fry 0.00957




Top 20 genes
Gene t fry
ACD 6858.0 7439.5
TINF2 6553.5 6059.0
NEIL1 5509.5 5620.0
H2AFX 4183.5 4392.0
MBD4 2266.5 4201.0
TERF2IP 2233.5 2953.0
SMUG1 1786.5 2835.0
UNG 1269.5 1262.0

Click HERE to show all gene set members

All member genes
t fry
ACD 6858.0 7439.5
H2AFX 4183.5 4392.0
MBD4 2266.5 4201.0
NEIL1 5509.5 5620.0
NEIL2 -3241.5 2272.0
NEIL3 -6284.5 -6856.0
NTHL1 730.5 -702.0
OGG1 1781.5 -7989.0
POT1 -13004.5 -10794.0
SMUG1 1786.5 2835.0
TDG -2822.5 -1684.0
TERF1 -11130.5 -8055.0
TERF2 -6552.5 -2422.0
TERF2IP 2233.5 2953.0
TINF2 6553.5 6059.0
UNG 1269.5 1262.0



Depyrimidination

Depyrimidination
metric value
setSize 16
pMANOVA 0.0333
p.adjustMANOVA 0.125
s.dist 0.504
s.t 0.338
s.fry 0.374
p.t 0.0192
p.fry 0.00957




Top 20 genes
Gene t fry
ACD 6858.0 7439.5
TINF2 6553.5 6059.0
NEIL1 5509.5 5620.0
H2AFX 4183.5 4392.0
MBD4 2266.5 4201.0
TERF2IP 2233.5 2953.0
SMUG1 1786.5 2835.0
UNG 1269.5 1262.0

Click HERE to show all gene set members

All member genes
t fry
ACD 6858.0 7439.5
H2AFX 4183.5 4392.0
MBD4 2266.5 4201.0
NEIL1 5509.5 5620.0
NEIL2 -3241.5 2272.0
NEIL3 -6284.5 -6856.0
NTHL1 730.5 -702.0
OGG1 1781.5 -7989.0
POT1 -13004.5 -10794.0
SMUG1 1786.5 2835.0
TDG -2822.5 -1684.0
TERF1 -11130.5 -8055.0
TERF2 -6552.5 -2422.0
TERF2IP 2233.5 2953.0
TINF2 6553.5 6059.0
UNG 1269.5 1262.0



Recognition and association of DNA glycosylase with site containing an affected pyrimidine

Recognition and association of DNA glycosylase with site containing an affected pyrimidine
metric value
setSize 16
pMANOVA 0.0333
p.adjustMANOVA 0.125
s.dist 0.504
s.t 0.338
s.fry 0.374
p.t 0.0192
p.fry 0.00957




Top 20 genes
Gene t fry
ACD 6858.0 7439.5
TINF2 6553.5 6059.0
NEIL1 5509.5 5620.0
H2AFX 4183.5 4392.0
MBD4 2266.5 4201.0
TERF2IP 2233.5 2953.0
SMUG1 1786.5 2835.0
UNG 1269.5 1262.0

Click HERE to show all gene set members

All member genes
t fry
ACD 6858.0 7439.5
H2AFX 4183.5 4392.0
MBD4 2266.5 4201.0
NEIL1 5509.5 5620.0
NEIL2 -3241.5 2272.0
NEIL3 -6284.5 -6856.0
NTHL1 730.5 -702.0
OGG1 1781.5 -7989.0
POT1 -13004.5 -10794.0
SMUG1 1786.5 2835.0
TDG -2822.5 -1684.0
TERF1 -11130.5 -8055.0
TERF2 -6552.5 -2422.0
TERF2IP 2233.5 2953.0
TINF2 6553.5 6059.0
UNG 1269.5 1262.0



Glucocorticoid biosynthesis

Glucocorticoid biosynthesis
metric value
setSize 10
pMANOVA 0.125
p.adjustMANOVA 0.295
s.dist 0.501
s.t -0.34
s.fry -0.368
p.t 0.0623
p.fry 0.0441




Top 20 genes
Gene t fry
SERPINA6 -17286.5 -15969
CYP21A2 -16455.5 -16422
HSD3B2 -17638.5 -13991
CYP17A1 -14380.5 -16245
CYP11B1 -12596.5 -17545
HSD11B2 -6472.5 -9528
HSD3B1 -8984.5 -5695
HSD11B1 -6079.5 -2754

Click HERE to show all gene set members

All member genes
t fry
CYP11B1 -12596.5 -17545
CYP11B2 5074.5 4604
CYP17A1 -14380.5 -16245
CYP21A2 -16455.5 -16422
HSD11B1 -6079.5 -2754
HSD11B2 -6472.5 -9528
HSD3B1 -8984.5 -5695
HSD3B2 -17638.5 -13991
POMC 1475.5 -2700
SERPINA6 -17286.5 -15969



Respiratory electron transport

Respiratory electron transport
metric value
setSize 90
pMANOVA 7.78e-09
p.adjustMANOVA 8.02e-07
s.dist 0.501
s.t 0.368
s.fry 0.339
p.t 1.51e-09
p.fry 2.65e-08




Top 20 genes
Gene t fry
COX6B1 7471.5 7558
NDUFB5 7720.5 7311
COX5B 7134.5 7743
UQCR11 7644.5 7012
NDUFS8 7541.5 7063
COX7A2L 7086.5 7298
COQ10B 6991.5 7200
CYC1 7257.5 6911
NDUFC1 6549.5 7653
ETFDH 7202.5 6843
NDUFA4 6849.5 6674
NDUFB10 6121.5 7289
TACO1 6038.5 6835
NDUFA2 6599.5 5966
UQCRFS1 6547.5 5823
UQCRQ 6095.5 6154
COX19 6688.5 5435
NDUFS2 6514.5 5340
NDUFB1 5107.5 6613
NDUFB7 5158.5 6087

Click HERE to show all gene set members

All member genes
t fry
ACAD9 -6165.5 -9260
COA1 4093.5 -5564
COQ10A -1692.5 -1685
COQ10B 6991.5 7200
COX11 -2301.5 686
COX14 4544.5 3915
COX16 -4464.5 -10363
COX18 -9918.5 -14567
COX19 6688.5 5435
COX20 4724.5 6363
COX4I1 2095.5 -2168
COX5A 727.5 145
COX5B 7134.5 7743
COX6A1 1948.5 -5027
COX6B1 7471.5 7558
COX6C -4746.5 2326
COX7A2L 7086.5 7298
COX7C -3966.5 -3628
COX8A -8063.5 -10984
CYC1 7257.5 6911
CYCS 4586.5 4022
ECSIT -1005.5 -942
ETFA -13282.5 -12398
ETFB -5743.5 -3339
ETFDH 7202.5 6843
LRPPRC -3991.5 -1306
NDUFA10 -983.5 -1890
NDUFA11 -3933.5 6777
NDUFA12 -3164.5 2372
NDUFA13 -8584.5 -12351
NDUFA2 6599.5 5966
NDUFA3 5372.5 5423
NDUFA4 6849.5 6674
NDUFA5 -12076.5 -10784
NDUFA6 3774.5 4624
NDUFA7 4018.5 2459
NDUFA8 5151.5 4098
NDUFA9 3767.5 3666
NDUFAB1 2709.5 1706
NDUFAF1 2314.5 1562
NDUFAF2 -8691.5 -7299
NDUFAF3 -6875.5 -8047
NDUFAF4 2850.5 1245
NDUFAF5 -15230.5 -11665
NDUFAF6 -6320.5 -4167
NDUFAF7 -14480.5 -11236
NDUFB1 5107.5 6613
NDUFB10 6121.5 7289
NDUFB2 3093.5 -6502
NDUFB3 -2409.5 -2769
NDUFB4 -526.5 -809
NDUFB5 7720.5 7311
NDUFB6 -13620.5 -8731
NDUFB7 5158.5 6087
NDUFB8 -15853.5 -17477
NDUFB9 1044.5 437
NDUFC1 6549.5 7653
NDUFC2 900.5 1026
NDUFS1 2280.5 2497
NDUFS2 6514.5 5340
NDUFS3 1758.5 1508
NDUFS4 -6042.5 -2269
NDUFS5 -10229.5 -13007
NDUFS6 2203.5 -6910
NDUFS7 -6828.5 -8354
NDUFS8 7541.5 7063
NDUFV1 2485.5 2587
NDUFV2 -7286.5 -11860
NDUFV3 -694.5 -413
NUBPL -14638.5 -6927
SCO1 3168.5 1820
SCO2 956.5 -3632
SDHA -3556.5 1705
SDHB -646.5 201
SDHC 4642.5 3866
SDHD -10264.5 -15904
SURF1 4631.5 5526
TACO1 6038.5 6835
TIMMDC1 -7380.5 -3493
TMEM126B 2415.5 1028
TMEM186 5073.5 5137
TRAP1 -10852.5 -6871
UQCR10 0.5 -13747
UQCR11 7644.5 7012
UQCRB -2130.5 352
UQCRC1 5750.5 5196
UQCRC2 4175.5 4348
UQCRFS1 6547.5 5823
UQCRH 5458.5 5044
UQCRQ 6095.5 6154



Presynaptic depolarization and calcium channel opening

Presynaptic depolarization and calcium channel opening
metric value
setSize 12
pMANOVA 0.0692
p.adjustMANOVA 0.202
s.dist 0.5
s.t -0.385
s.fry -0.318
p.t 0.0208
p.fry 0.0563




Top 20 genes
Gene t fry
CACNA2D3 -17572.5 -12596
CACNA2D1 -17588.5 -10008
CACNA2D2 -13300.5 -12646
CACNA1B -13122.5 -12578
CACNA1E -11985.5 -12843
CACNA1A -12236.5 -11917
CACNB2 -12813.5 -8670
CACNB4 -10848.5 -5329
CACNB3 -6251.5 -8067
CACNG4 -4788.5 -8426
CACNG2 -779.5 -925

Click HERE to show all gene set members

All member genes
t fry
CACNA1A -12236.5 -11917
CACNA1B -13122.5 -12578
CACNA1E -11985.5 -12843
CACNA2D1 -17588.5 -10008
CACNA2D2 -13300.5 -12646
CACNA2D3 -17572.5 -12596
CACNB1 2371.5 -3850
CACNB2 -12813.5 -8670
CACNB3 -6251.5 -8067
CACNB4 -10848.5 -5329
CACNG2 -779.5 -925
CACNG4 -4788.5 -8426



Defective GALNT12 causes CRCS1

Defective GALNT12 causes CRCS1
metric value
setSize 18
pMANOVA 0.0257
p.adjustMANOVA 0.103
s.dist 0.496
s.t -0.363
s.fry -0.338
p.t 0.00762
p.fry 0.013




Top 20 genes
Gene t fry
MUC17 -16716.5 -17705
MUC7 -17598.5 -14454
MUC12 -14357.5 -17621
MUC15 -16269.5 -13616
MUC2 -13555.5 -15644
MUC5B -13033.5 -15551
MUC4 -10364.5 -13278
MUCL1 -13010.5 -10240
GALNT12 -12427.5 -9076
MUC19 -14770.5 -7241
MUC21 -12162.5 -8231
MUC13 -11989.5 -5945
MUC6 -5999.5 -7394
MUC5AC -6996.5 -5081
MUC20 -4150.5 -2441

Click HERE to show all gene set members

All member genes
t fry
GALNT12 -12427.5 -9076
MUC1 4092.5 2926
MUC12 -14357.5 -17621
MUC13 -11989.5 -5945
MUC15 -16269.5 -13616
MUC16 1765.5 -133
MUC17 -16716.5 -17705
MUC19 -14770.5 -7241
MUC2 -13555.5 -15644
MUC20 -4150.5 -2441
MUC21 -12162.5 -8231
MUC3A 4273.5 -5607
MUC4 -10364.5 -13278
MUC5AC -6996.5 -5081
MUC5B -13033.5 -15551
MUC6 -5999.5 -7394
MUC7 -17598.5 -14454
MUCL1 -13010.5 -10240



Defective pyroptosis

Defective pyroptosis
metric value
setSize 11
pMANOVA 0.0615
p.adjustMANOVA 0.19
s.dist 0.493
s.t 0.287
s.fry 0.401
p.t 0.0996
p.fry 0.0213




Top 20 genes
Gene t fry
RBBP4 4803.5 5410
H2AFX 4183.5 4392
PRIM1 2688.5 6135
POLA2 3432.5 3000

Click HERE to show all gene set members

All member genes
t fry
DNMT1 -5754.5 -9485
DNMT3A -3844.5 -3510
DNMT3B 807.5 -1299
EED -5892.5 7335
EZH2 1531.5 -429
H2AFX 4183.5 4392
POLA2 3432.5 3000
PRIM1 2688.5 6135
PRIM2 -11824.5 -9571
RBBP4 4803.5 5410
SUZ12 -4148.5 819



Sensory perception of taste

Sensory perception of taste
metric value
setSize 47
pMANOVA 6.56e-05
p.adjustMANOVA 0.00121
s.dist 0.493
s.t -0.368
s.fry -0.327
p.t 1.24e-05
p.fry 0.000102




Top 20 genes
Gene t fry
TAS2R4 -17568.5 -15549
OTOP1 -15370.5 -17568
ITPR3 -15542.5 -17126
SCNN1D -15363.5 -15375
TAS1R1 -13190.5 -17406
TRPM4 -13681.5 -16608
SCNN1A -13850.5 -16069
GRM1 -14585.5 -15080
TAS2R1 -17229.5 -12533
GNAT3 -17650.5 -11788
TAS2R20 -16838.5 -12102
CALHM3 -13471.5 -14892
TAS2R39 -16181.5 -11987
TAS2R30 -15688.5 -12180
GRM4 -12980.5 -13977
KCNJ2 -11636.5 -14692
TAS2R41 -13867.5 -12223
TAS2R3 -14879.5 -11279
TAS2R50 -17428.5 -9483
TAS2R16 -15686.5 -10356

Click HERE to show all gene set members

All member genes
t fry
CALHM1 -4275.5 -9657
CALHM3 -13471.5 -14892
GNAT3 -17650.5 -11788
GNB1 -7694.5 -2232
GNB3 2244.5 5849
GNG13 1279.5 -1785
GRM1 -14585.5 -15080
GRM4 -12980.5 -13977
ITPR3 -15542.5 -17126
KCNJ2 -11636.5 -14692
OTOP1 -15370.5 -17568
PLCB2 -7290.5 -7402
SCN1B -7794.5 -16664
SCN2A -14075.5 -6210
SCN2B -783.5 567
SCN3A -10474.5 -6321
SCN4B -5826.5 -13617
SCN9A -14532.5 -10623
SCNN1A -13850.5 -16069
SCNN1B -7916.5 -13772
SCNN1D -15363.5 -15375
SCNN1G 3634.5 -3784
TAS1R1 -13190.5 -17406
TAS1R2 -1345.5 4216
TAS1R3 5212.5 4088
TAS2R1 -17229.5 -12533
TAS2R10 -12472.5 -8735
TAS2R13 2494.5 2625
TAS2R14 -14187.5 -9713
TAS2R16 -15686.5 -10356
TAS2R20 -16838.5 -12102
TAS2R3 -14879.5 -11279
TAS2R30 -15688.5 -12180
TAS2R31 -5312.5 -1431
TAS2R38 -10280.5 -5307
TAS2R39 -16181.5 -11987
TAS2R4 -17568.5 -15549
TAS2R40 1303.5 1078
TAS2R41 -13867.5 -12223
TAS2R43 0.5 -16130
TAS2R46 2695.5 -3409
TAS2R5 -9351.5 -6895
TAS2R50 -17428.5 -9483
TAS2R7 -13326.5 -6381
TAS2R8 -16859.5 -9032
TRPM4 -13681.5 -16608
TRPM5 -7636.5 -8828



Defective GALNT3 causes HFTC

Defective GALNT3 causes HFTC
metric value
setSize 18
pMANOVA 0.0288
p.adjustMANOVA 0.113
s.dist 0.492
s.t -0.348
s.fry -0.348
p.t 0.0106
p.fry 0.0107




Top 20 genes
Gene t fry
MUC17 -16716.5 -17705
MUC7 -17598.5 -14454
MUC12 -14357.5 -17621
MUC15 -16269.5 -13616
MUC2 -13555.5 -15644
MUC5B -13033.5 -15551
MUC4 -10364.5 -13278
MUCL1 -13010.5 -10240
MUC19 -14770.5 -7241
GALNT3 -8845.5 -11326
MUC21 -12162.5 -8231
MUC13 -11989.5 -5945
MUC6 -5999.5 -7394
MUC5AC -6996.5 -5081
MUC20 -4150.5 -2441

Click HERE to show all gene set members

All member genes
t fry
GALNT3 -8845.5 -11326
MUC1 4092.5 2926
MUC12 -14357.5 -17621
MUC13 -11989.5 -5945
MUC15 -16269.5 -13616
MUC16 1765.5 -133
MUC17 -16716.5 -17705
MUC19 -14770.5 -7241
MUC2 -13555.5 -15644
MUC20 -4150.5 -2441
MUC21 -12162.5 -8231
MUC3A 4273.5 -5607
MUC4 -10364.5 -13278
MUC5AC -6996.5 -5081
MUC5B -13033.5 -15551
MUC6 -5999.5 -7394
MUC7 -17598.5 -14454
MUCL1 -13010.5 -10240



Senescence-Associated Secretory Phenotype (SASP)

Senescence-Associated Secretory Phenotype (SASP)
metric value
setSize 53
pMANOVA 2.77e-05
p.adjustMANOVA 0.00062
s.dist 0.491
s.t 0.357
s.fry 0.338
p.t 7.04e-06
p.fry 2.06e-05




Top 20 genes
Gene t fry
ANAPC10 7404.5 7859
CDKN2B 7514.5 7555
RPS6KA1 7321.5 6710
CDKN1A 6427.5 7339
CEBPB 6992.5 6642
FZR1 6912.5 6379
ANAPC2 5556.5 5436
CDK4 5020.5 5193
CDC26 4210.5 5928
ANAPC1 5183.5 4706
RPS27A 5587.5 4209
ANAPC16 5075.5 4415
CDKN2C 4286.5 4959
H2AFX 4183.5 4392
VENTX 3391.5 5400
CXCL8 4448.5 3349
IL8 3159.5 3941
ANAPC7 3145.5 3494
UBB 2867.5 3319
UBA52 2705.5 3161

Click HERE to show all gene set members

All member genes
t fry
ANAPC1 5183.5 4706
ANAPC10 7404.5 7859
ANAPC11 1311.5 1682
ANAPC15 2772.5 -7813
ANAPC16 5075.5 4415
ANAPC2 5556.5 5436
ANAPC4 -4631.5 -6071
ANAPC5 -3242.5 2696
ANAPC7 3145.5 3494
CCNA1 -5463.5 -14738
CCNA2 -578.5 2008
CDC16 -612.5 -1905
CDC23 -8443.5 -16234
CDC26 4210.5 5928
CDC27 -15945.5 -13845
CDK2 -2387.5 -1542
CDK4 5020.5 5193
CDK6 -7556.5 -2452
CDKN1A 6427.5 7339
CDKN1B 1232.5 150
CDKN2A 1664.5 4856
CDKN2B 7514.5 7555
CDKN2C 4286.5 4959
CDKN2D 1658.5 -1227
CEBPB 6992.5 6642
CXCL8 4448.5 3349
EHMT1 780.5 231
EHMT2 -5956.5 -3322
FOS 2786.5 -3419
FZR1 6912.5 6379
H2AFX 4183.5 4392
IGFBP7 -6497.5 -5926
IL1A -11822.5 -13214
IL6 -1686.5 2021
IL8 3159.5 3941
JUN 3263.5 -3860
MAPK1 -13733.5 -12763
MAPK3 3991.5 -10254
MAPK7 -7767.5 -13311
NFKB1 -10310.5 -4355
RELA 676.5 575
RPS27A 5587.5 4209
RPS6KA1 7321.5 6710
RPS6KA2 -15640.5 -9918
STAT3 -10842.5 -12419
UBA52 2705.5 3161
UBB 2867.5 3319
UBC -2334.5 3044
UBE2C -1298.5 -1496
UBE2D1 3397.5 1550
UBE2E1 -3331.5 584
UBE2S -5173.5 6546
VENTX 3391.5 5400



Phase 0 - rapid depolarisation

Phase 0 - rapid depolarisation
metric value
setSize 31
pMANOVA 0.00154
p.adjustMANOVA 0.0133
s.dist 0.491
s.t -0.373
s.fry -0.319
p.t 0.000323
p.fry 0.00208




Top 20 genes
Gene t fry
SCN10A -17630.5 -15740
CAMK2B -16006.5 -16791
SCN4A -15882.5 -16337
CAMK2A -15435.5 -16517
CACNG7 -14997.5 -16185
SCN7A -17357.5 -12629
CACNA2D2 -13300.5 -12646
CACNG6 -11312.5 -14029
SCN9A -14532.5 -10623
SCN11A -16116.5 -9344
FGF11 -12011.5 -12458
SCN5A -10447.5 -12963
SCN8A -14854.5 -8801
SCN1B -7794.5 -16664
CAMK2D -11561.5 -10299
FGF14 -13025.5 -8938
CACNB2 -12813.5 -8670
CACNA1C -13592.5 -7896
SCN1A -14258.5 -7342
SCN2A -14075.5 -6210

Click HERE to show all gene set members

All member genes
t fry
CACNA1C -13592.5 -7896
CACNA2D2 -13300.5 -12646
CACNB1 2371.5 -3850
CACNB2 -12813.5 -8670
CACNG4 -4788.5 -8426
CACNG6 -11312.5 -14029
CACNG7 -14997.5 -16185
CACNG8 -1146.5 -4274
CALM1 -7179.5 -9385
CAMK2A -15435.5 -16517
CAMK2B -16006.5 -16791
CAMK2D -11561.5 -10299
CAMK2G 2488.5 3325
FGF11 -12011.5 -12458
FGF12 -11034.5 -7473
FGF14 -13025.5 -8938
RANGRF 4882.5 4052
SCN10A -17630.5 -15740
SCN11A -16116.5 -9344
SCN1A -14258.5 -7342
SCN1B -7794.5 -16664
SCN2A -14075.5 -6210
SCN2B -783.5 567
SCN3A -10474.5 -6321
SCN3B 6229.5 7459
SCN4A -15882.5 -16337
SCN4B -5826.5 -13617
SCN5A -10447.5 -12963
SCN7A -17357.5 -12629
SCN8A -14854.5 -8801
SCN9A -14532.5 -10623



Base-Excision Repair, AP Site Formation

Base-Excision Repair, AP Site Formation
metric value
setSize 18
pMANOVA 0.0209
p.adjustMANOVA 0.0914
s.dist 0.491
s.t 0.312
s.fry 0.378
p.t 0.0218
p.fry 0.00544




Top 20 genes
Gene t fry
ACD 6858.0 7439.5
TINF2 6553.5 6059.0
NEIL1 5509.5 5620.0
H2AFX 4183.5 4392.0
MBD4 2266.5 4201.0
TERF2IP 2233.5 2953.0
SMUG1 1786.5 2835.0
UNG 1269.5 1262.0

Click HERE to show all gene set members

All member genes
t fry
ACD 6858.0 7439.5
H2AFX 4183.5 4392.0
MBD4 2266.5 4201.0
MPG -5050.5 3824.0
MUTYH -2151.5 -3006.0
NEIL1 5509.5 5620.0
NEIL2 -3241.5 2272.0
NEIL3 -6284.5 -6856.0
NTHL1 730.5 -702.0
OGG1 1781.5 -7989.0
POT1 -13004.5 -10794.0
SMUG1 1786.5 2835.0
TDG -2822.5 -1684.0
TERF1 -11130.5 -8055.0
TERF2 -6552.5 -2422.0
TERF2IP 2233.5 2953.0
TINF2 6553.5 6059.0
UNG 1269.5 1262.0



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.0                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.3                                       
##  [5] tibble_3.1.8                                       
##  [6] dplyr_1.0.10                                       
##  [7] echarts4r_0.4.4                                    
##  [8] tictoc_1.1                                         
##  [9] kableExtra_1.3.4                                   
## [10] data.table_1.14.2                                  
## [11] ENmix_1.32.0                                       
## [12] doParallel_1.0.17                                  
## [13] qqman_0.1.8                                        
## [14] RCircos_1.2.2                                      
## [15] beeswarm_0.4.0                                     
## [16] forestplot_3.1.0                                   
## [17] abind_1.4-5                                        
## [18] checkmate_2.1.0                                    
## [19] reshape2_1.4.4                                     
## [20] gplots_3.1.3                                       
## [21] eulerr_6.1.1                                       
## [22] GEOquery_2.64.2                                    
## [23] RColorBrewer_1.1-3                                 
## [24] IlluminaHumanMethylation450kmanifest_0.4.0         
## [25] topconfects_1.12.0                                 
## [26] DMRcatedata_2.14.0                                 
## [27] ExperimentHub_2.4.0                                
## [28] AnnotationHub_3.4.0                                
## [29] BiocFileCache_2.4.0                                
## [30] dbplyr_2.2.1                                       
## [31] DMRcate_2.10.0                                     
## [32] limma_3.52.4                                       
## [33] missMethyl_1.30.0                                  
## [34] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [35] R.utils_2.12.0                                     
## [36] R.oo_1.25.0                                        
## [37] R.methodsS3_1.8.2                                  
## [38] plyr_1.8.7                                         
## [39] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [40] minfi_1.42.0                                       
## [41] bumphunter_1.38.0                                  
## [42] locfit_1.5-9.6                                     
## [43] iterators_1.0.14                                   
## [44] foreach_1.5.2                                      
## [45] Biostrings_2.64.1                                  
## [46] XVector_0.36.0                                     
## [47] SummarizedExperiment_1.26.1                        
## [48] Biobase_2.56.0                                     
## [49] MatrixGenerics_1.8.1                               
## [50] matrixStats_0.62.0                                 
## [51] GenomicRanges_1.48.0                               
## [52] GenomeInfoDb_1.32.4                                
## [53] IRanges_2.30.1                                     
## [54] S4Vectors_0.34.0                                   
## [55] BiocGenerics_0.42.0                                
## [56] mitch_1.8.0                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.1           
##   [3] tidyr_1.2.1                   bit64_4.0.5                  
##   [5] knitr_1.40                    DelayedArray_0.22.0          
##   [7] rpart_4.1.16                  KEGGREST_1.36.3              
##   [9] RCurl_1.98-1.9                AnnotationFilter_1.20.0      
##  [11] generics_0.1.3                GenomicFeatures_1.48.4       
##  [13] preprocessCore_1.58.0         RSQLite_2.2.18               
##  [15] bit_4.0.4                     tzdb_0.3.0                   
##  [17] webshot_0.5.4                 xml2_1.3.3                   
##  [19] httpuv_1.6.6                  assertthat_0.2.1             
##  [21] xfun_0.33                     hms_1.1.2                    
##  [23] jquerylib_0.1.4               evaluate_0.17                
##  [25] promises_1.2.0.1              fansi_1.0.3                  
##  [27] restfulr_0.0.15               scrime_1.3.5                 
##  [29] progress_1.2.2                caTools_1.18.2               
##  [31] readxl_1.4.1                  DBI_1.1.3                    
##  [33] geneplotter_1.74.0            htmlwidgets_1.5.4            
##  [35] reshape_0.8.9                 purrr_0.3.5                  
##  [37] ellipsis_0.3.2                backports_1.4.1              
##  [39] permute_0.9-7                 calibrate_1.7.7              
##  [41] annotate_1.74.0               biomaRt_2.52.0               
##  [43] deldir_1.0-6                  sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.2                   ensembldb_2.20.2             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.1      prettyunits_1.1.1            
##  [53] mclust_5.4.10                 svglite_2.1.0                
##  [55] cluster_2.1.4                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.2                 
##  [59] genefilter_1.78.0             labeling_0.4.2               
##  [61] edgeR_3.38.4                  pkgconfig_2.0.3              
##  [63] nlme_3.1-160                  ProtGenerics_1.28.0          
##  [65] nnet_7.3-18                   rlang_1.0.6                  
##  [67] lifecycle_1.0.3               filelock_1.0.2               
##  [69] dichromat_2.0-0.1             polyclip_1.10-0              
##  [71] cellranger_1.1.0              rngtools_1.5.2               
##  [73] base64_2.0.1                  Matrix_1.5-1                 
##  [75] Rhdf5lib_1.18.2               base64enc_0.1-3              
##  [77] viridisLite_0.4.1             png_0.1-7                    
##  [79] rjson_0.2.21                  bitops_1.0-7                 
##  [81] KernSmooth_2.23-20            rhdf5filters_1.8.0           
##  [83] blob_1.2.3                    DelayedMatrixStats_1.18.1    
##  [85] doRNG_1.8.2                   stringr_1.4.1                
##  [87] nor1mix_1.3-0                 readr_2.1.3                  
##  [89] jpeg_0.1-9                    scales_1.2.1                 
##  [91] memoise_2.0.1                 magrittr_2.0.3               
##  [93] zlibbioc_1.42.0               compiler_4.2.1               
##  [95] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [97] Rsamtools_2.12.0              cli_3.4.1                    
##  [99] DSS_2.44.0                    htmlTable_2.4.1              
## [101] Formula_1.2-4                 MASS_7.3-58.1                
## [103] tidyselect_1.2.0              stringi_1.7.8                
## [105] highr_0.9                     yaml_2.3.5                   
## [107] askpass_1.1                   latticeExtra_0.6-30          
## [109] sass_0.4.2                    VariantAnnotation_1.42.1     
## [111] tools_4.2.1                   rstudioapi_0.14              
## [113] foreign_0.8-83                bsseq_1.32.0                 
## [115] gridExtra_2.3                 farver_2.1.1                 
## [117] digest_0.6.29                 BiocManager_1.30.18          
## [119] shiny_1.7.2                   quadprog_1.5-8               
## [121] Rcpp_1.0.9                    siggenes_1.70.0              
## [123] BiocVersion_3.15.2            later_1.3.0                  
## [125] org.Hs.eg.db_3.15.0           httr_1.4.4                   
## [127] AnnotationDbi_1.58.0          biovizBase_1.44.0            
## [129] colorspace_2.0-3              polylabelr_0.2.0             
## [131] rvest_1.0.3                   XML_3.99-0.11                
## [133] splines_4.2.1                 statmod_1.4.37               
## [135] multtest_2.52.0               systemfonts_1.0.4            
## [137] xtable_1.8-4                  jsonlite_1.8.2               
## [139] dynamicTreeCut_1.63-1         R6_2.5.1                     
## [141] Hmisc_4.7-1                   pillar_1.8.1                 
## [143] htmltools_0.5.3               mime_0.12                    
## [145] glue_1.6.2                    fastmap_1.1.0                
## [147] BiocParallel_1.30.4           interactiveDisplayBase_1.34.0
## [149] beanplot_1.3.1                codetools_0.2-18             
## [151] utf8_1.2.2                    lattice_0.20-45              
## [153] bslib_0.4.0                   curl_4.3.3                   
## [155] openssl_2.0.3                 interp_1.1-3                 
## [157] survival_3.4-0                rmarkdown_2.17               
## [159] munsell_0.5.0                 rhdf5_2.40.0                 
## [161] GenomeInfoDbData_1.2.8        HDF5Array_1.24.2             
## [163] impute_1.70.0                 gtable_0.3.1

END of report