date generated: 2021-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##        t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
## A1BG  -3.00456260   0.9487855   0.2301905  0.100632259
## AAAS  -0.21556406   0.4334437   0.1059355  0.230035602
## AACS  -1.05346370   0.8690806   0.2587493  0.682403328
## AAGAB  1.57942406   0.5727567   0.8530991  0.001540913
## AAK1  -0.09752886   0.7201373  -1.5284346  0.360863030
## AAMDC -1.53003779   0.8935852   0.3093931  0.383673218
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genes_in_profile 9281
duplicated_genes_present 0
num_profile_genes_in_sets 2812
num_profile_genes_not_in_sets 6469

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets:
Gene sets metrics
Gene sets metrics
num_genesets 16
num_genesets_excluded 0
num_genesets_included 16
Genes by sector
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth Count
1 -1 -1 -1 -1 101
2 1 -1 -1 -1 92
3 -1 1 -1 -1 375
4 1 1 -1 -1 344
5 -1 -1 1 -1 101
6 1 -1 1 -1 120
7 -1 1 1 -1 450
8 1 1 1 -1 415
9 -1 -1 1 0 1
10 -1 -1 -1 1 122
11 1 -1 -1 1 122
12 -1 0 -1 1 1
13 -1 1 -1 1 1763
14 0 1 -1 1 1
15 1 1 -1 1 1770
16 -1 1 0 1 1
17 -1 -1 1 1 101
18 1 -1 1 1 101
19 -1 1 1 1 1732
20 1 1 1 1 1568
Number of significant gene sets (FDR<0.05)= 16

Gene sets by sector


Gene sets by sector
s.t0_crp_RNA s.t0_crp_meth s.pod_crp_RNA s.pod_crp_meth Count
1 -1 -1 1 -1 1
2 1 1 1 -1 1
3 -1 -1 -1 1 6
4 1 -1 -1 1 1
5 -1 -1 1 1 2
6 1 -1 1 1 2
7 -1 1 1 1 3

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 16 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.t0_crp_RNA s.t0_crp_meth s.pod_crp_RNA s.pod_crp_meth p.t0_crp_RNA p.t0_crp_meth p.pod_crp_RNA p.pod_crp_meth
Eukaryotic Translation Elongation 70 7.69e-38 1.23e-36 0.935 -0.62500 -0.09000 -0.658 0.20500 1.50e-19 0.1940 1.73e-21 0.003040
Neutrophil degranulation 305 1.65e-35 1.32e-34 0.439 -0.02440 -0.02700 0.432 -0.06370 4.69e-01 0.4210 3.42e-38 0.058000
Peptide chain elongation 67 2.56e-35 1.36e-34 0.923 -0.61000 -0.10200 -0.653 0.20800 5.99e-18 0.1480 2.26e-20 0.003290
Formation of a pool of free 40S subunits 76 4.35e-34 1.74e-33 0.853 -0.55000 -0.08240 -0.621 0.18200 1.11e-16 0.2150 8.44e-21 0.006210
rRNA processing in the nucleus and cytosol 154 8.88e-34 2.84e-33 0.601 -0.24700 -0.06040 -0.528 0.13300 1.42e-07 0.1980 1.50e-29 0.004570
Innate Immune System 616 2.03e-30 5.40e-30 0.288 -0.01050 -0.00718 0.287 0.00104 6.62e-01 0.7660 4.70e-33 0.966000
Nonsense-Mediated Decay (NMD) 86 1.31e-24 2.98e-24 0.689 -0.40700 -0.05420 -0.511 0.21500 7.72e-11 0.3870 2.86e-16 0.000578
Immune System 1142 3.00e-22 5.99e-22 0.184 0.03580 -0.01120 0.176 0.03490 4.95e-02 0.5380 3.52e-22 0.055500
Metabolism of RNA 535 3.65e-20 6.48e-20 0.257 0.00411 -0.04120 -0.234 0.09640 8.73e-01 0.1100 7.18e-20 0.000176
Signal Transduction 1289 2.88e-12 4.61e-12 0.131 -0.03620 0.01410 0.114 0.05230 3.69e-02 0.4150 5.43e-11 0.002530
Signaling by Receptor Tyrosine Kinases 284 3.13e-10 4.55e-10 0.246 -0.08980 0.04170 0.222 0.03300 9.83e-03 0.2310 1.58e-10 0.343000
Metabolism of lipids 427 1.54e-09 2.05e-09 0.196 0.02380 0.07080 0.178 -0.03710 4.06e-01 0.0134 5.10e-10 0.194000
Signaling by ROBO receptors 153 3.43e-09 4.22e-09 0.323 -0.21400 -0.01720 -0.186 0.15300 5.15e-06 0.7150 7.75e-05 0.001160
Signaling by Interleukins 263 4.28e-08 4.89e-08 0.217 -0.03800 -0.00527 0.182 0.11100 2.92e-01 0.8840 4.30e-07 0.002120
Cytokine Signaling in Immune system 424 1.02e-07 1.08e-07 0.166 0.07610 -0.01690 0.102 0.10500 8.02e-03 0.5560 3.96e-04 0.000249
Platelet activation, signaling and aggregation 133 1.35e-07 1.35e-07 0.307 -0.11000 0.05350 0.273 0.06800 2.96e-02 0.2890 5.81e-08 0.178000


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.t0_crp_RNA s.t0_crp_meth s.pod_crp_RNA s.pod_crp_meth p.t0_crp_RNA p.t0_crp_meth p.pod_crp_RNA p.pod_crp_meth
Eukaryotic Translation Elongation 70 7.69e-38 1.23e-36 0.935 -0.62500 -0.09000 -0.658 0.20500 1.50e-19 0.1940 1.73e-21 0.003040
Neutrophil degranulation 305 1.65e-35 1.32e-34 0.439 -0.02440 -0.02700 0.432 -0.06370 4.69e-01 0.4210 3.42e-38 0.058000
Peptide chain elongation 67 2.56e-35 1.36e-34 0.923 -0.61000 -0.10200 -0.653 0.20800 5.99e-18 0.1480 2.26e-20 0.003290
Formation of a pool of free 40S subunits 76 4.35e-34 1.74e-33 0.853 -0.55000 -0.08240 -0.621 0.18200 1.11e-16 0.2150 8.44e-21 0.006210
rRNA processing in the nucleus and cytosol 154 8.88e-34 2.84e-33 0.601 -0.24700 -0.06040 -0.528 0.13300 1.42e-07 0.1980 1.50e-29 0.004570
Innate Immune System 616 2.03e-30 5.40e-30 0.288 -0.01050 -0.00718 0.287 0.00104 6.62e-01 0.7660 4.70e-33 0.966000
Nonsense-Mediated Decay (NMD) 86 1.31e-24 2.98e-24 0.689 -0.40700 -0.05420 -0.511 0.21500 7.72e-11 0.3870 2.86e-16 0.000578
Immune System 1142 3.00e-22 5.99e-22 0.184 0.03580 -0.01120 0.176 0.03490 4.95e-02 0.5380 3.52e-22 0.055500
Metabolism of RNA 535 3.65e-20 6.48e-20 0.257 0.00411 -0.04120 -0.234 0.09640 8.73e-01 0.1100 7.18e-20 0.000176
Signal Transduction 1289 2.88e-12 4.61e-12 0.131 -0.03620 0.01410 0.114 0.05230 3.69e-02 0.4150 5.43e-11 0.002530
Signaling by Receptor Tyrosine Kinases 284 3.13e-10 4.55e-10 0.246 -0.08980 0.04170 0.222 0.03300 9.83e-03 0.2310 1.58e-10 0.343000
Metabolism of lipids 427 1.54e-09 2.05e-09 0.196 0.02380 0.07080 0.178 -0.03710 4.06e-01 0.0134 5.10e-10 0.194000
Signaling by ROBO receptors 153 3.43e-09 4.22e-09 0.323 -0.21400 -0.01720 -0.186 0.15300 5.15e-06 0.7150 7.75e-05 0.001160
Signaling by Interleukins 263 4.28e-08 4.89e-08 0.217 -0.03800 -0.00527 0.182 0.11100 2.92e-01 0.8840 4.30e-07 0.002120
Cytokine Signaling in Immune system 424 1.02e-07 1.08e-07 0.166 0.07610 -0.01690 0.102 0.10500 8.02e-03 0.5560 3.96e-04 0.000249
Platelet activation, signaling and aggregation 133 1.35e-07 1.35e-07 0.307 -0.11000 0.05350 0.273 0.06800 2.96e-02 0.2890 5.81e-08 0.178000



Detailed Gene set reports


Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
metric value
setSize 70
pMANOVA 7.69e-38
p.adjustMANOVA 1.23e-36
s.dist 0.935
s.t0_crp_RNA -0.625
s.t0_crp_meth -0.09
s.pod_crp_RNA -0.658
s.pod_crp_meth 0.205
p.t0_crp_RNA 1.5e-19
p.t0_crp_meth 0.194
p.pod_crp_RNA 1.73e-21
p.pod_crp_meth 0.00304



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA t0_crp_RNA
RPS2 -4571 -4698
RPL3 -4610 -4508
EEF1G -4201 -4651
EEF1B2 -4265 -4461
RPLP2 -3815 -4667
RPS5 -4065 -4113
RPS12 -3896 -4261
RPLP0 -4060 -4068
RPL27A -3904 -4061
RPS3 -4143 -3753
EEF1A1 -4432 -3462
RPS27A -4078 -3731
RPS16 -3448 -4379
EEF2 -3170 -4680
RPL29 -3643 -3990
RPS10 -3457 -4168
RPL37 -2971 -4723
RPL35 -3508 -3999
RPS29 -3034 -4598
RPS18 -3284 -4218

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
EEF1A1 -3462 2007 -4432 2941
EEF1B2 -4461 5596 -4265 3976
EEF1D -4492 7623 -2131 5789
EEF1G -4651 718 -4201 111
EEF2 -4680 1309 -3170 4195
FAU -4223 5971 -437 6875
RPL10A -2021 3601 -3665 3590
RPL11 -2195 4759 -3631 -495
RPL13 -2399 2561 -2415 6187
RPL13A -2217 1446 -4059 5521
RPL14 -2732 1645 -4433 -798
RPL15 -2979 2857 -3337 1424
RPL17 -3043 1594 -3926 2296
RPL18 -3380 7714 -3552 4478
RPL18A -3938 751 -3444 4254
RPL22 -2825 5674 -4182 1020
RPL23 -1858 5701 -3100 2729
RPL23A 48 7818 -4430 4559
RPL26 -2272 4855 -3465 6407
RPL26L1 -972 2107 2314 3971
RPL27A -4061 5311 -3904 1697
RPL28 -2225 2129 -798 4754
RPL29 -3990 4921 -3643 2875
RPL3 -4508 360 -4610 6751
RPL31 -3651 495 -3411 -34
RPL32 -3564 4776 -3623 5998
RPL34 -904 906 -3944 6513
RPL35 -3999 2909 -3508 4823
RPL36 -4523 -158 -2815 2877
RPL36AL -4195 7236 -1732 6350
RPL37 -4723 3433 -2971 5392
RPL37A -3969 1847 -2033 4981
RPL38 -4417 4342 -2941 4430
RPL39L -2468 4218 -28 5079
RPL4 -2456 997 -4254 1394
RPL41 -3631 4792 -2682 821
RPL6 466 3352 -3950 1979
RPL7 -2841 5004 -4292 7008
RPL8 -4442 7620 -2781 5093
RPL9 -990 4307 -3377 844
RPLP0 -4068 5078 -4060 4850
RPLP1 -4307 4259 -1607 1521
RPLP2 -4667 3685 -3815 6421
RPS10 -4168 2356 -3457 3925
RPS11 -3884 1199 -3013 4224
RPS12 -4261 7672 -3896 6329
RPS15 -3350 1899 -2308 5621
RPS15A -3437 1657 -3621 6110
RPS16 -4379 4270 -3448 5979
RPS18 -4218 4809 -3284 4162
RPS19 -3954 1402 -2451 -362
RPS2 -4698 -704 -4571 6973
RPS20 -1234 4742 -3936 3461
RPS23 -3376 -353 -3858 2986
RPS24 -35 6157 -2288 -518
RPS25 -2395 138 -4129 1797
RPS26 -1529 6099 -2398 5515
RPS27A -3731 2481 -4078 2589
RPS27L 3563 2925 1087 1405
RPS28 -4025 17 -2863 -1178
RPS29 -4598 3919 -3034 5600
RPS3 -3753 4053 -4143 4598
RPS3A 1196 4024 -4365 7066
RPS5 -4113 3314 -4065 6070
RPS6 -3204 4732 -4317 361
RPS7 -2809 3926 -3695 4407
RPS8 -1253 -347 -3213 -79
RPS9 -3353 1940 922 627
RPSA 1973 687 -1923 2072
UBA52 -3208 4386 -596 -69





Neutrophil degranulation

Neutrophil degranulation
metric value
setSize 305
pMANOVA 1.65e-35
p.adjustMANOVA 1.32e-34
s.dist 0.439
s.t0_crp_RNA -0.0244
s.t0_crp_meth -0.027
s.pod_crp_RNA 0.432
s.pod_crp_meth -0.0637
p.t0_crp_RNA 0.469
p.t0_crp_meth 0.421
p.pod_crp_RNA 3.42e-38
p.pod_crp_meth 0.058



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA pod_crp_meth
P2RX1 4586 -1947
UNC13D 4403 -1904
TYROBP 4152 -1995
CTSZ 4162 -1978
CD300A 4103 -1998
PYCARD 4319 -1818
TRPM2 4355 -1792
NAPRT 4098 -1869
C3AR1 4547 -1594
ATP6V0A1 4481 -1569
MNDA 3506 -1994
IGF2R 3850 -1657
SERPINB1 4236 -1477
CYSTM1 3572 -1740
AGPAT2 4455 -1386
ARSB 3997 -1526
LAMTOR1 3758 -1587
QPCT 3998 -1472
VAT1 4292 -1357
SLC15A4 3676 -1575

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
A1BG -4720 7280 525 567
ACAA1 -1087 6265 4528 5788
ACLY -1395 2347 3652 2976
ACTR10 2603 5113 1646 4867
ACTR1B -3875 3798 -2148 2629
ACTR2 3144 4932 2747 3844
ADAM10 2914 3590 3423 2760
ADAM8 -2204 7454 2256 5096
ADGRE5 -2627 2052 3671 -1468
AGA -2883 -401 -2619 2162
AGL 2065 2754 -959 1016
AGPAT2 -3761 -328 4455 -1386
ALAD -4161 371 4014 1057
ALDOA -1859 643 4238 5366
ALDOC -367 7284 -2691 65
ALOX5 330 6127 4345 5385
AMPD3 -1687 4553 3545 3216
ANO6 -849 7646 -21 1102
AP1M1 -4217 2143 3873 1777
APAF1 1473 7512 2266 -809
APEH -3872 429 1730 832
APRT -4283 7658 -2811 2643
ARHGAP9 -2519 389 4113 6255
ARL8A -3571 135 3462 -1057
ARMC8 3399 4263 67 2641
ARPC5 2109 2335 3836 2611
ARSA 1972 -580 3635 523
ARSB 1416 6851 3997 -1526
ASAH1 2991 3487 4461 2174
ATAD3B -3224 5569 -2736 4810
ATG7 2082 1256 2282 3847
ATP11A -1708 5464 4170 132
ATP11B 1100 -213 1786 -241
ATP6V0A1 -73 5522 4481 -1569
ATP6V0C -819 2497 4204 2933
ATP6V1D 3158 446 3682 1096
ATP8A1 -1321 -197 -4498 -913
ATP8B4 80 -467 612 -1099
B2M 3496 3645 -3314 -9
B4GALT1 -2606 7929 1953 7041
BIN2 -3373 3302 4006 5389
BRI3 -1874 3754 4413 -1176
BST2 1250 -703 383 -1933
C3AR1 4000 1722 4547 -1594
C6orf120 -845 7883 319 3829
CAB39 2427 -206 2233 7106
CAND1 2021 1725 -3244 2163
CAP1 497 5559 3138 2034
CAPN1 -3906 5471 3918 1819
CAT 282 -220 3549 -1204
CCT2 1454 3443 -4591 194
CCT8 2610 2003 -111 2904
CD300A 2225 -861 4103 -1998
CD44 498 4392 3154 4897
CD47 2166 2442 -3816 6601
CD53 2247 -462 3926 6482
CD55 1738 3285 4145 1455
CD58 4062 5810 3835 -611
CD59 -1703 4468 -1328 -1682
CD63 -2910 7177 4520 5433
CDK13 -2241 5468 9 5777
CEACAM1 -237 822 1684 5458
CEP290 4268 7316 -2743 7000
CKAP4 -813 8287 3854 -987
CMTM6 3583 4072 2869 1926
CNN2 -1565 2034 1954 -418
COMMD3 3610 606 665 -1960
COMMD9 1680 85 3383 2239
COPB1 4354 2889 2313 2637
COTL1 671 2421 4276 6759
CPNE1 -1872 4807 -478 5131
CPNE3 1598 2499 -94 -1441
CPPED1 340 5747 4044 -641
CREG1 -2492 1563 2917 -1059
CSNK2B 63 7476 2450 4742
CSTB 469 6900 4229 2893
CTSA -2481 2086 4047 2720
CTSB 83 7057 4475 -965
CTSC 2238 2310 3599 1311
CTSD -3067 8404 4479 6620
CTSS 2274 -506 2686 -1544
CTSZ -1191 -74 4162 -1978
CYB5R3 -4015 4980 3732 3239
CYBA -2911 5359 4087 2019
CYFIP1 644 8297 4331 256
CYSTM1 594 7301 3572 -1740
DBNL -4518 2964 3614 -406
DEGS1 -1317 4783 -164 3203
DERA 3518 7409 3669 3602
DGAT1 -3399 6428 2057 -576
DIAPH1 -659 5118 910 2371
DNAJC13 3873 207 3651 408
DNAJC3 2858 8289 3092 6470
DNAJC5 -2985 3110 3776 -1396
DPP7 -4644 7245 -1735 6584
DSN1 2407 2698 -1398 -996
DYNC1H1 -2872 1165 -441 4433
DYNC1LI1 3353 6061 2935 3242
DYNLL1 -405 5371 1250 5150
DYNLT1 2953 4660 2802 5599
EEF1A1 -3462 2007 -4432 2941
EEF2 -4680 1309 -3170 4195
ENPP4 1515 1338 -2234 3170
ERP44 3533 127 1159 920
FABP5 1248 3657 2416 2233
FAF2 230 7630 1614 2842
FGR -1601 6431 4539 -1074
FTH1 -378 3718 2380 3117
FTL 609 3955 3972 -1424
FUCA1 -689 2325 2425 1656
FUCA2 1128 614 2428 -1234
GAA -1924 1082 3079 2768
GALNS -2319 6550 3709 3670
GCA 3226 2697 4151 5559
GDI2 3001 7874 2004 3343
GGH 2821 6701 1044 3861
GHDC -3703 2847 1243 -571
GLB1 890 7186 4196 1828
GLIPR1 3846 390 2195 5591
GM2A 2719 6404 4388 6361
GMFG 254 6320 3611 6367
GNS 1404 5454 4533 4428
GOLGA7 1327 3410 -2030 3104
GPI -2280 6574 1799 5672
GRN -475 3078 4312 4937
GSDMD -2417 4172 1671 -91
GSTP1 -976 6809 683 -1350
GUSB -2488 4868 4470 2338
GYG1 -319 6447 3938 -231
HEBP2 -1887 5561 2156 552
HEXB 1519 7559 2594 2906
HGSNAT -63 352 -1489 3342
HLA-A -4080 2266 -2368 -1093
HLA-B -821 510 896 -730
HLA-C 51 6767 1218 4448
HLA-H -4350 7821 -546 4988
HMGB1 1943 2521 -3489 3222
HMOX2 -3769 699 -4339 6411
HSP90AA1 3100 4857 -2176 6208
HSP90AB1 1227 824 -4305 -1224
HSPA1A -3490 1106 2517 -920
HSPA1B 1576 750 1718 655
HVCN1 -951 1427 1485 -385
IDH1 3628 3280 4526 3454
IGF2R -4041 -23 3850 -1657
ILF2 2531 -350 -1689 2770
IMPDH1 -1286 6 4428 2600
IMPDH2 -3789 5334 -4679 250
IQGAP1 -6 372 3381 587
IQGAP2 2140 2768 3344 3888
IST1 2520 1926 2863 1014
ITGAL -1994 4404 1129 7036
ITGAV 2010 3274 3023 -370
ITGB2 -4211 745 4253 6424
KCMF1 1322 -488 1586 3310
KCNAB2 -4643 5909 2760 -600
KPNB1 2659 5901 -47 1140
LAIR1 -901 6730 4482 3425
LAMP1 -4014 7954 3219 2553
LAMTOR1 -4534 -643 3758 -1587
LAMTOR2 -3989 -286 3497 -1340
LAMTOR3 3368 6744 792 957
LPCAT1 -2710 -419 1992 1418
LTA4H 2233 5699 4301 798
MAN2B1 -2647 7254 2518 6387
MANBA 3782 4762 2996 6844
MAPK1 -745 2758 4197 6097
MAPK14 1563 2227 4024 2465
MIF -3715 2437 -3047 3355
MLEC -1358 5314 -1498 2183
MMP25 -966 6396 4100 6852
MNDA 3361 1442 3506 -1994
MPO -3878 344 -3645 -1967
MVP -3502 7998 3433 6953
NAPRT 214 -73 4098 -1869
NBEAL2 -2403 5606 4127 1726
NCKAP1L 650 1928 4458 -320
NCSTN 1556 -453 4578 1224
NDUFC2 -2586 5313 2549 2881
NEU1 660 3057 4459 1899
NHLRC3 3852 5873 2633 4505
NIT2 2452 1153 -3459 -141
NME2 1390 1732 -173 -880
NPC2 2405 6347 2830 2198
ORMDL3 -3219 2570 -3756 3085
OSCAR 1666 2313 4583 7120
OSTF1 1009 7525 2469 6468
P2RX1 2272 2764 4586 -1947
PA2G4 1938 2826 -2412 5242
PAFAH1B2 2330 4486 909 2435
PDAP1 -4405 8096 3697 2952
PDXK -1102 4954 2867 1492
PFKL -4475 23 464 -1730
PGAM1 -1229 1586 4418 1307
PGM1 -3622 4559 1829 776
PGM2 1298 3342 3609 5133
PKM -1111 1474 4062 3231
PLAC8 -1486 3803 4406 1235
PLAU -1912 5281 914 -1527
PLAUR 226 4310 4189 -861
PLD1 2370 2188 4049 -902
PLEKHO2 703 6284 4254 6697
PNP 823 2158 3217 3516
PPIA -239 5602 -1924 4554
PPIE 1995 6743 -2167 6025
PRCP 2944 6346 2835 611
PRDX6 -1247 4144 -345 5477
PRKCD 301 8167 4500 6358
PRTN3 -4653 8354 -2832 5619
PSAP 506 1283 3823 628
PSEN1 2104 1717 4209 4954
PSMA2 1509 4929 -836 5163
PSMA5 3047 4175 -2828 3319
PSMB1 -371 2981 -803 5409
PSMB7 -2378 1587 2955 4198
PSMC3 -2624 4680 847 736
PSMD1 2911 5546 2375 56
PSMD11 4009 2032 2637 3521
PSMD12 4511 5250 2167 3681
PSMD13 -998 7807 1482 561
PSMD14 3360 3896 85 6314
PSMD2 -3334 6719 2097 3610
PSMD3 -4637 3063 1629 5579
PSMD6 1854 3171 3275 2336
PSMD7 3595 864 596 2079
PTGES2 -4318 -433 -1375 -901
PTPN6 -1174 2534 4395 6540
PTPRC 3660 1759 2823 -936
PTPRJ -2062 6860 3552 7167
PTPRN2 -1502 1639 -965 6583
PYCARD -1515 3142 4319 -1818
PYGB -3390 -229 -1259 141
QPCT 1033 1841 3998 -1472
QSOX1 -2300 6788 4519 5725
RAB10 2203 1022 4224 3067
RAB14 3720 1861 1150 -378
RAB18 4478 1161 1696 2764
RAB24 1932 257 4083 -168
RAB27A 3269 7260 2952 222
RAB37 -1677 7528 -2789 409
RAB3A -4569 3507 482 4347
RAB3D 604 5944 3885 1148
RAB4B -2727 7770 3909 4687
RAB5B -516 1208 1896 1957
RAB5C -2850 2984 3898 797
RAB6A 3034 6426 2839 3323
RAB7A 837 -522 3489 -124
RAC1 3574 7484 4225 5539
RAP1A 4512 2607 2624 6567
RAP1B 2749 6134 2033 5966
RAP2B -283 6562 394 5291
RHOA 2796 1879 3280 4033
RHOF -3403 3511 -4235 6476
RHOG -703 3967 4093 3664
RNASET2 -1180 732 3304 7087
ROCK1 4037 2208 2623 2732
S100A11 1465 3952 4310 6087
S100P -3641 627 3560 3303
SCAMP1 2598 7802 -3481 2645
SDCBP 3311 7419 3605 3834
SERPINB1 990 -241 4236 -1477
SERPINB6 -3927 7977 3455 2823
SLC11A1 -326 1277 4588 4001
SLC15A4 -384 -645 3676 -1575
SLC27A2 3534 3271 -3276 -1409
SLC2A3 -2653 4133 3706 -1209
SLC44A2 -3555 1449 11 4322
SLCO4C1 838 1673 1214 -99
SNAP23 2642 7973 1694 -471
SNAP29 -4308 6060 3209 3148
SPTAN1 -4171 369 -4508 -407
SRP14 2388 5802 1918 5762
STBD1 785 6119 -200 -658
STK10 -3634 3470 2725 -688
STK11IP -4178 4530 3990 2122
STOM 312 -756 1358 -1584
SURF4 -2330 5219 1962 3679
SVIP 2044 4128 -3340 1104
TBC1D10C -4516 3143 -3275 6910
TCIRG1 -2526 4545 4576 1353
TLR2 3806 6774 4156 4128
TMBIM1 -3251 2134 3467 -47
TMC6 -3434 1580 -1994 6748
TMEM179B -176 1544 388 5595
TMEM30A 3654 7686 1750 6658
TMEM63A -691 1367 -3328 2620
TNFRSF1B -1307 1250 4281 6868
TOLLIP -3659 1231 2911 664
TOM1 -3899 5174 4227 4279
TRAPPC1 -1916 3999 3336 5232
TRPM2 -2751 7757 4355 -1792
TSPAN14 -2003 917 4079 4962
TUBB -357 3701 -2272 6246
TUBB4B -2428 6398 2462 7160
TXNDC5 2037 7500 -1760 -1871
TYROBP -1849 830 4152 -1995
UNC13D -3097 481 4403 -1904
VAMP8 -2659 3376 1656 868
VAPA 2045 3824 3031 4245
VAT1 -3926 1426 4292 -1357
VCL -1153 1830 476 3614
VCP -2285 7849 1665 1908
XRCC5 1691 3512 -1013 1327
XRCC6 661 2803 -3543 3282
YPEL5 1717 -147 2447 3986





Peptide chain elongation

Peptide chain elongation
metric value
setSize 67
pMANOVA 2.56e-35
p.adjustMANOVA 1.36e-34
s.dist 0.923
s.t0_crp_RNA -0.61
s.t0_crp_meth -0.102
s.pod_crp_RNA -0.653
s.pod_crp_meth 0.208
p.t0_crp_RNA 5.99e-18
p.t0_crp_meth 0.148
p.pod_crp_RNA 2.26e-20
p.pod_crp_meth 0.00329



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA t0_crp_RNA
RPS2 -4571 -4698
RPL3 -4610 -4508
RPLP2 -3815 -4667
RPS5 -4065 -4113
RPS12 -3896 -4261
RPLP0 -4060 -4068
RPL27A -3904 -4061
RPS3 -4143 -3753
EEF1A1 -4432 -3462
RPS27A -4078 -3731
RPS16 -3448 -4379
EEF2 -3170 -4680
RPL29 -3643 -3990
RPS10 -3457 -4168
RPL37 -2971 -4723
RPL35 -3508 -3999
RPS29 -3034 -4598
RPS18 -3284 -4218
RPS6 -4317 -3204
RPL18A -3444 -3938

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
EEF1A1 -3462 2007 -4432 2941
EEF2 -4680 1309 -3170 4195
FAU -4223 5971 -437 6875
RPL10A -2021 3601 -3665 3590
RPL11 -2195 4759 -3631 -495
RPL13 -2399 2561 -2415 6187
RPL13A -2217 1446 -4059 5521
RPL14 -2732 1645 -4433 -798
RPL15 -2979 2857 -3337 1424
RPL17 -3043 1594 -3926 2296
RPL18 -3380 7714 -3552 4478
RPL18A -3938 751 -3444 4254
RPL22 -2825 5674 -4182 1020
RPL23 -1858 5701 -3100 2729
RPL23A 48 7818 -4430 4559
RPL26 -2272 4855 -3465 6407
RPL26L1 -972 2107 2314 3971
RPL27A -4061 5311 -3904 1697
RPL28 -2225 2129 -798 4754
RPL29 -3990 4921 -3643 2875
RPL3 -4508 360 -4610 6751
RPL31 -3651 495 -3411 -34
RPL32 -3564 4776 -3623 5998
RPL34 -904 906 -3944 6513
RPL35 -3999 2909 -3508 4823
RPL36 -4523 -158 -2815 2877
RPL36AL -4195 7236 -1732 6350
RPL37 -4723 3433 -2971 5392
RPL37A -3969 1847 -2033 4981
RPL38 -4417 4342 -2941 4430
RPL39L -2468 4218 -28 5079
RPL4 -2456 997 -4254 1394
RPL41 -3631 4792 -2682 821
RPL6 466 3352 -3950 1979
RPL7 -2841 5004 -4292 7008
RPL8 -4442 7620 -2781 5093
RPL9 -990 4307 -3377 844
RPLP0 -4068 5078 -4060 4850
RPLP1 -4307 4259 -1607 1521
RPLP2 -4667 3685 -3815 6421
RPS10 -4168 2356 -3457 3925
RPS11 -3884 1199 -3013 4224
RPS12 -4261 7672 -3896 6329
RPS15 -3350 1899 -2308 5621
RPS15A -3437 1657 -3621 6110
RPS16 -4379 4270 -3448 5979
RPS18 -4218 4809 -3284 4162
RPS19 -3954 1402 -2451 -362
RPS2 -4698 -704 -4571 6973
RPS20 -1234 4742 -3936 3461
RPS23 -3376 -353 -3858 2986
RPS24 -35 6157 -2288 -518
RPS25 -2395 138 -4129 1797
RPS26 -1529 6099 -2398 5515
RPS27A -3731 2481 -4078 2589
RPS27L 3563 2925 1087 1405
RPS28 -4025 17 -2863 -1178
RPS29 -4598 3919 -3034 5600
RPS3 -3753 4053 -4143 4598
RPS3A 1196 4024 -4365 7066
RPS5 -4113 3314 -4065 6070
RPS6 -3204 4732 -4317 361
RPS7 -2809 3926 -3695 4407
RPS8 -1253 -347 -3213 -79
RPS9 -3353 1940 922 627
RPSA 1973 687 -1923 2072
UBA52 -3208 4386 -596 -69





Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
metric value
setSize 76
pMANOVA 4.35e-34
p.adjustMANOVA 1.74e-33
s.dist 0.853
s.t0_crp_RNA -0.55
s.t0_crp_meth -0.0824
s.pod_crp_RNA -0.621
s.pod_crp_meth 0.182
p.t0_crp_RNA 1.11e-16
p.t0_crp_meth 0.215
p.pod_crp_RNA 8.44e-21
p.pod_crp_meth 0.00621



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA t0_crp_RNA
RPS2 -4571 -4698
RPL3 -4610 -4508
RPLP2 -3815 -4667
RPS5 -4065 -4113
RPS12 -3896 -4261
RPLP0 -4060 -4068
EIF3B -4157 -3948
RPL27A -3904 -4061
RPS3 -4143 -3753
RPS27A -4078 -3731
RPS16 -3448 -4379
EIF3L -3540 -4194
RPL29 -3643 -3990
RPS10 -3457 -4168
RPL37 -2971 -4723
RPL35 -3508 -3999
RPS29 -3034 -4598
RPS18 -3284 -4218
RPS6 -4317 -3204
RPL18A -3444 -3938

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
EIF3A 728 186 -641 5853
EIF3B -3948 -637 -4157 -704
EIF3E 3043 3996 -4004 503
EIF3F -4699 1781 -1541 1471
EIF3G -4429 1815 -692 3038
EIF3H -554 4996 -2590 3706
EIF3I -3483 2651 -1095 696
EIF3J 3642 3047 -2652 737
EIF3K -2643 8378 -128 6634
EIF3L -4194 6675 -3540 2568
EIF3M 3156 7216 -2454 5834
FAU -4223 5971 -437 6875
RPL10A -2021 3601 -3665 3590
RPL11 -2195 4759 -3631 -495
RPL13 -2399 2561 -2415 6187
RPL13A -2217 1446 -4059 5521
RPL14 -2732 1645 -4433 -798
RPL15 -2979 2857 -3337 1424
RPL17 -3043 1594 -3926 2296
RPL18 -3380 7714 -3552 4478
RPL18A -3938 751 -3444 4254
RPL22 -2825 5674 -4182 1020
RPL23 -1858 5701 -3100 2729
RPL23A 48 7818 -4430 4559
RPL26 -2272 4855 -3465 6407
RPL26L1 -972 2107 2314 3971
RPL27A -4061 5311 -3904 1697
RPL28 -2225 2129 -798 4754
RPL29 -3990 4921 -3643 2875
RPL3 -4508 360 -4610 6751
RPL31 -3651 495 -3411 -34
RPL32 -3564 4776 -3623 5998
RPL34 -904 906 -3944 6513
RPL35 -3999 2909 -3508 4823
RPL36 -4523 -158 -2815 2877
RPL36AL -4195 7236 -1732 6350
RPL37 -4723 3433 -2971 5392
RPL37A -3969 1847 -2033 4981
RPL38 -4417 4342 -2941 4430
RPL39L -2468 4218 -28 5079
RPL4 -2456 997 -4254 1394
RPL41 -3631 4792 -2682 821
RPL6 466 3352 -3950 1979
RPL7 -2841 5004 -4292 7008
RPL8 -4442 7620 -2781 5093
RPL9 -990 4307 -3377 844
RPLP0 -4068 5078 -4060 4850
RPLP1 -4307 4259 -1607 1521
RPLP2 -4667 3685 -3815 6421
RPS10 -4168 2356 -3457 3925
RPS11 -3884 1199 -3013 4224
RPS12 -4261 7672 -3896 6329
RPS15 -3350 1899 -2308 5621
RPS15A -3437 1657 -3621 6110
RPS16 -4379 4270 -3448 5979
RPS18 -4218 4809 -3284 4162
RPS19 -3954 1402 -2451 -362
RPS2 -4698 -704 -4571 6973
RPS20 -1234 4742 -3936 3461
RPS23 -3376 -353 -3858 2986
RPS24 -35 6157 -2288 -518
RPS25 -2395 138 -4129 1797
RPS26 -1529 6099 -2398 5515
RPS27A -3731 2481 -4078 2589
RPS27L 3563 2925 1087 1405
RPS28 -4025 17 -2863 -1178
RPS29 -4598 3919 -3034 5600
RPS3 -3753 4053 -4143 4598
RPS3A 1196 4024 -4365 7066
RPS5 -4113 3314 -4065 6070
RPS6 -3204 4732 -4317 361
RPS7 -2809 3926 -3695 4407
RPS8 -1253 -347 -3213 -79
RPS9 -3353 1940 922 627
RPSA 1973 687 -1923 2072
UBA52 -3208 4386 -596 -69





rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol
metric value
setSize 154
pMANOVA 8.88e-34
p.adjustMANOVA 2.84e-33
s.dist 0.601
s.t0_crp_RNA -0.247
s.t0_crp_meth -0.0604
s.pod_crp_RNA -0.528
s.pod_crp_meth 0.133
p.t0_crp_RNA 1.42e-07
p.t0_crp_meth 0.198
p.pod_crp_RNA 1.5e-29
p.pod_crp_meth 0.00457



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA t0_crp_RNA
FBL -4594 -4678
RPS2 -4571 -4698
RPL3 -4610 -4508
RPLP2 -3815 -4667
RRP9 -3731 -4587
RPS5 -4065 -4113
RPS12 -3896 -4261
RPLP0 -4060 -4068
RPL27A -3904 -4061
RPS3 -4143 -3753
RPS27A -4078 -3731
RPS16 -3448 -4379
RPL29 -3643 -3990
EXOSC2 -3761 -3836
RPS10 -3457 -4168
EXOSC5 -3823 -3756
RPL37 -2971 -4723
RPL35 -3508 -3999
RPS29 -3034 -4598
RPS18 -3284 -4218

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
BMS1 -1273 279 -4313 -1753
BYSL -2328 5900 -2573 6806
C1D 4279 3651 206 2322
CSNK1D -4441 6564 2787 3046
CSNK1E -3951 7015 -3414 3000
DCAF13 -562 1410 -1783 862
DDX21 2972 7462 -1540 3312
DDX47 4326 892 -3647 -50
DDX49 -4479 3907 1633 5580
DDX52 4531 3595 579 -204
DHX37 -3145 6236 -2526 4194
DIS3 4375 4884 -1622 -754
EBNA1BP2 -556 1401 -3067 6233
ERI1 3766 -203 768 -139
EXOSC1 2149 7237 992 316
EXOSC10 1827 1777 -2188 802
EXOSC2 -3836 -378 -3761 5343
EXOSC3 851 4957 110 3245
EXOSC4 -2860 5195 3343 64
EXOSC5 -3756 469 -3823 790
EXOSC6 -1352 3467 -3661 1534
EXOSC7 -4443 4094 -2938 -158
EXOSC8 3032 5356 -3616 1364
FAU -4223 5971 -437 6875
FBL -4678 -91 -4594 -43
FCF1 2808 5725 -1239 6761
FTSJ3 -2540 4963 1385 4235
GAR1 -224 3758 -2986 879
GNL3 2241 1853 -4428 1201
HEATR1 566 6362 -3326 5200
IMP3 -1621 6086 -3137 5540
IMP4 -2501 4256 -3803 3786
ISG20L2 530 2755 -15 6436
KRR1 2893 -801 -2865 -1950
LTV1 2852 2898 -1941 2915
MPHOSPH10 4488 5449 -2942 5400
MPHOSPH6 1961 6222 -949 5533
NCL -1980 6791 -4315 5053
NHP2 -3191 6971 -2519 4826
NIP7 1970 5730 -3733 4218
NOB1 -2719 -262 -4364 2003
NOC4L -1413 5509 2788 -799
NOL11 3694 -390 -4414 2571
NOL12 -297 5999 2186 -1549
NOL6 -4372 6081 -3107 4556
NOL9 1673 -787 -3236 -1444
NOP10 -1724 2394 4174 2081
NOP14 -2035 -731 -4619 2209
NOP2 -3532 5036 -2782 6401
NOP56 -390 117 -3865 996
NOP58 3566 2112 -4420 1333
PDCD11 -2808 1973 -3660 3455
PELP1 -637 6658 -3306 2742
PES1 -4103 222 -2386 3288
PNO1 2611 1456 -3399 6494
PWP2 -3288 3400 -3239 5075
RBM28 -2460 5591 -2557 3412
RCL1 -2020 7155 -3537 6341
RIOK1 2656 7804 -1376 6496
RIOK2 3564 1632 -3897 1638
RIOK3 3495 2135 1073 3472
RPL10A -2021 3601 -3665 3590
RPL11 -2195 4759 -3631 -495
RPL13 -2399 2561 -2415 6187
RPL13A -2217 1446 -4059 5521
RPL14 -2732 1645 -4433 -798
RPL15 -2979 2857 -3337 1424
RPL17 -3043 1594 -3926 2296
RPL18 -3380 7714 -3552 4478
RPL18A -3938 751 -3444 4254
RPL22 -2825 5674 -4182 1020
RPL23 -1858 5701 -3100 2729
RPL23A 48 7818 -4430 4559
RPL26 -2272 4855 -3465 6407
RPL26L1 -972 2107 2314 3971
RPL27A -4061 5311 -3904 1697
RPL28 -2225 2129 -798 4754
RPL29 -3990 4921 -3643 2875
RPL3 -4508 360 -4610 6751
RPL31 -3651 495 -3411 -34
RPL32 -3564 4776 -3623 5998
RPL34 -904 906 -3944 6513
RPL35 -3999 2909 -3508 4823
RPL36 -4523 -158 -2815 2877
RPL36AL -4195 7236 -1732 6350
RPL37 -4723 3433 -2971 5392
RPL37A -3969 1847 -2033 4981
RPL38 -4417 4342 -2941 4430
RPL39L -2468 4218 -28 5079
RPL4 -2456 997 -4254 1394
RPL41 -3631 4792 -2682 821
RPL6 466 3352 -3950 1979
RPL7 -2841 5004 -4292 7008
RPL8 -4442 7620 -2781 5093
RPL9 -990 4307 -3377 844
RPLP0 -4068 5078 -4060 4850
RPLP1 -4307 4259 -1607 1521
RPLP2 -4667 3685 -3815 6421
RPP14 3290 6084 -993 2236
RPP21 -3292 6702 -86 2599
RPP25 -2510 7139 -3453 5743
RPP30 3476 4936 -3223 668
RPP38 3369 1308 -2914 4779
RPP40 1457 2935 -4562 570
RPS10 -4168 2356 -3457 3925
RPS11 -3884 1199 -3013 4224
RPS12 -4261 7672 -3896 6329
RPS15 -3350 1899 -2308 5621
RPS15A -3437 1657 -3621 6110
RPS16 -4379 4270 -3448 5979
RPS18 -4218 4809 -3284 4162
RPS19 -3954 1402 -2451 -362
RPS2 -4698 -704 -4571 6973
RPS20 -1234 4742 -3936 3461
RPS23 -3376 -353 -3858 2986
RPS24 -35 6157 -2288 -518
RPS25 -2395 138 -4129 1797
RPS26 -1529 6099 -2398 5515
RPS27A -3731 2481 -4078 2589
RPS27L 3563 2925 1087 1405
RPS28 -4025 17 -2863 -1178
RPS29 -4598 3919 -3034 5600
RPS3 -3753 4053 -4143 4598
RPS3A 1196 4024 -4365 7066
RPS5 -4113 3314 -4065 6070
RPS6 -3204 4732 -4317 361
RPS7 -2809 3926 -3695 4407
RPS8 -1253 -347 -3213 -79
RPS9 -3353 1940 922 627
RPSA 1973 687 -1923 2072
RRP1 -894 4246 340 5199
RRP7A -281 3244 -1932 1582
RRP9 -4587 -253 -3731 653
SENP3 -1093 8054 1649 5393
SNU13 -1800 -638 -3664 7052
TBL3 -3751 5261 19 5417
TEX10 3497 -297 -4086 1204
THUMPD1 3126 1431 -4395 -871
TRMT112 -4008 7769 -160 1929
TSR1 -341 6406 -4621 6837
TSR3 -4199 1625 -151 6368
UBA52 -3208 4386 -596 -69
UTP15 4103 2192 -3831 5062
UTP18 1555 4515 1472 3357
UTP20 2389 4984 -3079 5084
UTP3 -823 5891 -608 3926
UTP6 3752 1891 -2359 3932
WDR12 2088 2282 -541 6792
WDR18 -2689 2119 -1828 -1077
WDR3 -11 550 -3655 -1385
WDR36 2325 4898 -2570 6599
WDR43 1173 2125 -4139 5508
WDR75 2774 3709 -4340 4613
XRN2 1078 2908 3514 -29





Innate Immune System

Innate Immune System
metric value
setSize 616
pMANOVA 2.03e-30
p.adjustMANOVA 5.4e-30
s.dist 0.288
s.t0_crp_RNA -0.0105
s.t0_crp_meth -0.00718
s.pod_crp_RNA 0.287
s.pod_crp_meth 0.00104
p.t0_crp_RNA 0.662
p.t0_crp_meth 0.766
p.pod_crp_RNA 4.7e-33
p.pod_crp_meth 0.966



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA t0_crp_RNA
PELI3 4288 -4660
NLRX1 4251 -4356
ITGB2 4253 -4211
LAMTOR1 3758 -4534
MAPK3 3649 -4620
VAT1 4292 -3926
AGPAT2 4455 -3761
ALAD 4014 -4161
STK11IP 3990 -4178
TOM1 4227 -3899
AP1M1 3873 -4217
DBNL 3614 -4518
PDAP1 3697 -4405
DNM2 3699 -4239
IGF2R 3850 -4041
CAPN1 3918 -3906
CYB5R3 3732 -4015
DTX4 3400 -4129
LAMTOR2 3497 -3989
SNAP29 3209 -4308

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
A1BG -4720 7280 525 567
AAMP -4607 1163 -1372 7118
ABI1 4121 520 2868 3253
ABI2 570 1453 -3567 -206
ABL1 -3241 5957 1585 2469
ACAA1 -1087 6265 4528 5788
ACLY -1395 2347 3652 2976
ACTB -373 4248 4005 5446
ACTG1 -3456 6407 3191 1603
ACTR10 2603 5113 1646 4867
ACTR1B -3875 3798 -2148 2629
ACTR2 3144 4932 2747 3844
ACTR3 2753 4481 2482 5950
ADAM10 2914 3590 3423 2760
ADAM8 -2204 7454 2256 5096
ADGRE5 -2627 2052 3671 -1468
AGA -2883 -401 -2619 2162
AGL 2065 2754 -959 1016
AGPAT2 -3761 -328 4455 -1386
AHCYL1 1297 6888 1605 2692
AIM2 2677 -558 720 -1275
ALAD -4161 371 4014 1057
ALDOA -1859 643 4238 5366
ALDOC -367 7284 -2691 65
ALOX5 330 6127 4345 5385
AMPD3 -1687 4553 3545 3216
ANO6 -849 7646 -21 1102
AP1M1 -4217 2143 3873 1777
APAF1 1473 7512 2266 -809
APEH -3872 429 1730 832
APP -1029 7569 1303 6621
APRT -4283 7658 -2811 2643
ARHGAP9 -2519 389 4113 6255
ARL8A -3571 135 3462 -1057
ARMC8 3399 4263 67 2641
ARPC1B -3236 2831 4244 1709
ARPC2 1775 5683 3457 2292
ARPC3 2785 4820 3580 3208
ARPC5 2109 2335 3836 2611
ARSA 1972 -580 3635 523
ARSB 1416 6851 3997 -1526
ASAH1 2991 3487 4461 2174
ATAD3B -3224 5569 -2736 4810
ATF1 4365 685 1579 2989
ATG12 4083 4620 -2436 6821
ATG5 4418 1135 -2277 -680
ATG7 2082 1256 2282 3847
ATOX1 -2402 7999 2468 390
ATP11A -1708 5464 4170 132
ATP11B 1100 -213 1786 -241
ATP6V0A1 -73 5522 4481 -1569
ATP6V0A2 1039 5229 -2100 6651
ATP6V0B -2906 4920 4040 5502
ATP6V0C -819 2497 4204 2933
ATP6V0D1 -717 5801 4411 6934
ATP6V0E1 -98 5534 3098 1836
ATP6V0E2 688 -8 -3868 -1325
ATP6V1A 2260 3916 3165 -1495
ATP6V1B2 1335 2965 3679 -1553
ATP6V1C1 3195 3435 3307 6757
ATP6V1D 3158 446 3682 1096
ATP6V1E1 3127 6210 2844 4775
ATP6V1F -2969 2955 1967 -699
ATP6V1G2 -783 7744 -3696 3740
ATP6V1H 2094 5695 1932 2559
ATP8A1 -1321 -197 -4498 -913
ATP8B4 80 -467 612 -1099
B2M 3496 3645 -3314 -9
B4GALT1 -2606 7929 1953 7041
BAIAP2 -3214 6287 -510 2757
BCL10 3129 6246 1603 2575
BCL2 891 55 -3102 7020
BCL2L1 168 5903 -129 5968
BIN2 -3373 3302 4006 5389
BIRC2 4449 4494 -741 6624
BIRC3 3504 588 -4618 4816
BRI3 -1874 3754 4413 -1176
BRK1 -4091 8027 -825 3071
BST2 1250 -703 383 -1933
BTRC -2069 66 -3130 -923
C3AR1 4000 1722 4547 -1594
C6orf120 -845 7883 319 3829
C8G -1876 4665 114 -1364
CAB39 2427 -206 2233 7106
CALM1 1287 3980 -2201 4501
CAND1 2021 1725 -3244 2163
CAP1 497 5559 3138 2034
CAPN1 -3906 5471 3918 1819
CAPZA1 4166 7801 2992 999
CAPZA2 3798 3735 2976 4666
CARD11 -3851 5791 -4243 6542
CARD9 -3315 -774 3670 -1761
CASP1 4199 -379 2331 7029
CASP10 2029 1610 1690 -1805
CASP4 3211 507 2271 -96
CASP8 2071 5784 -2229 5447
CASP9 110 698 4367 3202
CAT 282 -220 3549 -1204
CCT2 1454 3443 -4591 194
CCT8 2610 2003 -111 2904
CD247 -4182 3160 -4496 6034
CD300A 2225 -861 4103 -1998
CD4 -528 5984 -2076 909
CD44 498 4392 3154 4897
CD46 4402 5368 2807 5538
CD47 2166 2442 -3816 6601
CD53 2247 -462 3926 6482
CD55 1738 3285 4145 1455
CD58 4062 5810 3835 -611
CD59 -1703 4468 -1328 -1682
CD63 -2910 7177 4520 5433
CD81 -2406 2412 -2059 3296
CDC34 -4179 6224 2873 -408
CDC42 3320 7040 2741 856
CDK13 -2241 5468 9 5777
CEACAM1 -237 822 1684 5458
CEP290 4268 7316 -2743 7000
CFL1 -3249 4059 3672 1646
CHUK 2695 2702 2681 1111
CKAP4 -813 8287 3854 -987
CMTM6 3583 4072 2869 1926
CNN2 -1565 2034 1954 -418
CNPY3 -2430 3188 3017 1242
COMMD3 3610 606 665 -1960
COMMD9 1680 85 3383 2239
COPB1 4354 2889 2313 2637
COTL1 671 2421 4276 6759
CPNE1 -1872 4807 -478 5131
CPNE3 1598 2499 -94 -1441
CPPED1 340 5747 4044 -641
CRCP 998 6155 1033 4707
CREB1 2387 5046 -1542 1422
CREBBP -4011 6807 2122 892
CREG1 -2492 1563 2917 -1059
CRK 3068 5936 3523 6596
CSNK2B 63 7476 2450 4742
CSTB 469 6900 4229 2893
CTNNB1 2009 6708 3025 5069
CTSA -2481 2086 4047 2720
CTSB 83 7057 4475 -965
CTSC 2238 2310 3599 1311
CTSD -3067 8404 4479 6620
CTSL 873 8363 4377 3028
CTSS 2274 -506 2686 -1544
CTSV -308 7141 -258 5169
CTSZ -1191 -74 4162 -1978
CUL1 4355 1572 -4161 -1190
CYB5R3 -4015 4980 3732 3239
CYBA -2911 5359 4087 2019
CYFIP1 644 8297 4331 256
CYFIP2 -1585 4227 -2032 6157
CYLD 1079 5350 -4487 5704
CYSTM1 594 7301 3572 -1740
DBNL -4518 2964 3614 -406
DDX41 -4055 5715 1011 4425
DDX58 4465 2907 -3747 185
DEGS1 -1317 4783 -164 3203
DERA 3518 7409 3669 3602
DGAT1 -3399 6428 2057 -576
DHX36 3868 1789 -1657 6438
DHX58 3998 1444 -1341 -30
DHX9 243 6405 -2418 5545
DIAPH1 -659 5118 910 2371
DNAJC13 3873 207 3651 408
DNAJC3 2858 8289 3092 6470
DNAJC5 -2985 3110 3776 -1396
DNM1 2874 2154 2211 1607
DNM2 -4239 6583 3699 3063
DPP7 -4644 7245 -1735 6584
DSN1 2407 2698 -1398 -996
DTX4 -4129 5372 3400 5143
DUSP3 -328 6561 3398 2260
DUSP4 1176 3581 -1089 2494
DUSP6 -534 7727 -1313 -1941
DUSP7 -2585 6442 -1315 722
DYNC1H1 -2872 1165 -441 4433
DYNC1LI1 3353 6061 2935 3242
DYNLL1 -405 5371 1250 5150
DYNLT1 2953 4660 2802 5599
ECSIT -1973 6302 1201 1450
EEA1 3244 1440 -457 5334
EEF1A1 -3462 2007 -4432 2941
EEF2 -4680 1309 -3170 4195
ELMO1 -2007 4440 -587 939
ELMO2 2276 3622 3753 6108
ENPP4 1515 1338 -2234 3170
EP300 -1082 3351 3310 4900
ERP44 3533 127 1159 920
FABP5 1248 3657 2416 2233
FADD -32 2272 2169 -329
FAF2 230 7630 1614 2842
FBXW11 -1449 8406 480 -1506
FGR -1601 6431 4539 -1074
FOS -4562 4067 -1568 5645
FTH1 -378 3718 2380 3117
FTL 609 3955 3972 -1424
FUCA1 -689 2325 2425 1656
FUCA2 1128 614 2428 -1234
FYN -2118 2799 -2956 2793
GAA -1924 1082 3079 2768
GAB2 -2692 347 3912 2390
GALNS -2319 6550 3709 3670
GCA 3226 2697 4151 5559
GDI2 3001 7874 2004 3343
GGH 2821 6701 1044 3861
GHDC -3703 2847 1243 -571
GLB1 890 7186 4196 1828
GLIPR1 3846 390 2195 5591
GM2A 2719 6404 4388 6361
GMFG 254 6320 3611 6367
GNS 1404 5454 4533 4428
GOLGA7 1327 3410 -2030 3104
GPI -2280 6574 1799 5672
GRAP2 -2746 6230 -2761 3631
GRB2 29 5972 4230 6239
GRN -475 3078 4312 4937
GSDMD -2417 4172 1671 -91
GSTP1 -976 6809 683 -1350
GUSB -2488 4868 4470 2338
GYG1 -319 6447 3938 -231
GZMM -3093 -219 -3628 7249
HEBP2 -1887 5561 2156 552
HERC5 4477 1222 -3630 -1037
HEXB 1519 7559 2594 2906
HGSNAT -63 352 -1489 3342
HLA-A -4080 2266 -2368 -1093
HLA-B -821 510 896 -730
HLA-C 51 6767 1218 4448
HLA-E -950 3730 -1002 5634
HLA-H -4350 7821 -546 4988
HMGB1 1943 2521 -3489 3222
HMOX2 -3769 699 -4339 6411
HRAS -3453 1483 -1282 -823
HSP90AA1 3100 4857 -2176 6208
HSP90AB1 1227 824 -4305 -1224
HSP90B1 4301 7702 -1893 2127
HSPA1A -3490 1106 2517 -920
HSPA1B 1576 750 1718 655
HVCN1 -951 1427 1485 -385
ICAM2 -608 980 -4564 4818
ICAM3 -4729 900 2016 6838
IDH1 3628 3280 4526 3454
IFIH1 4466 4707 -2544 2681
IGF2R -4041 -23 3850 -1657
IKBKB -1861 958 1970 -912
IKBKE -39 5956 3231 6703
ILF2 2531 -350 -1689 2770
IMPDH1 -1286 6 4428 2600
IMPDH2 -3789 5334 -4679 250
IQGAP1 -6 372 3381 587
IQGAP2 2140 2768 3344 3888
IRAK2 -3547 7809 -2980 4685
IRAK3 1420 2776 4357 666
IRF3 -2649 2791 -1301 4240
IRF7 2494 6595 3230 3556
ISG15 3651 -537 -3046 6539
IST1 2520 1926 2863 1014
ITCH 421 6841 732 4853
ITGAL -1994 4404 1129 7036
ITGAV 2010 3274 3023 -370
ITGB2 -4211 745 4253 6424
ITK -839 -349 -4350 -1699
ITPR1 -1901 6612 -1565 1789
ITPR2 1162 4456 2298 -44
ITPR3 -748 2875 -2503 2189
JUN -3724 2763 -598 1283
KCMF1 1322 -488 1586 3310
KCNAB2 -4643 5909 2760 -600
KPNB1 2659 5901 -47 1140
KRAS 4442 4004 1217 3139
LAIR1 -901 6730 4482 3425
LAMP1 -4014 7954 3219 2553
LAMTOR1 -4534 -643 3758 -1587
LAMTOR2 -3989 -286 3497 -1340
LAMTOR3 3368 6744 792 957
LAT2 -1732 6599 4173 -1714
LCK -1825 2493 -4488 7243
LCP2 2815 -273 200 -428
LGMN -2484 6373 -3917 2706
LIMK1 -3358 -627 3471 -1748
LPCAT1 -2710 -419 1992 1418
LRRFIP1 3522 4814 3045 5296
LTA4H 2233 5699 4301 798
MALT1 633 7648 -4558 2545
MAN2B1 -2647 7254 2518 6387
MANBA 3782 4762 2996 6844
MAP2K1 -1421 -148 3921 1533
MAP2K3 -2498 38 3714 2411
MAP2K4 1784 3155 1767 4763
MAP2K6 3151 2164 3939 4791
MAP2K7 -4193 2092 431 1764
MAP3K1 1458 3815 1771 2247
MAP3K14 -2001 1381 -3221 4220
MAP3K7 2692 3839 1057 -147
MAP3K8 826 6359 4551 3266
MAPK1 -745 2758 4197 6097
MAPK14 1563 2227 4024 2465
MAPK3 -4620 -475 3649 1978
MAPK7 -2209 3007 3966 -244
MAPK8 -1037 6156 -3737 4553
MAPK9 -260 1152 -2605 157
MAPKAPK2 -3939 1416 2421 3265
MAPKAPK3 -1142 58 4580 2896
MAVS -3312 5447 2245 4280
MEF2A 2271 7441 3276 3013
MIF -3715 2437 -3047 3355
MLEC -1358 5314 -1498 2183
MMP25 -966 6396 4100 6852
MNDA 3361 1442 3506 -1994
MPO -3878 344 -3645 -1967
MUC1 -1022 6782 2987 6713
MUC12 3257 3997 -166 4640
MUC5B 758 -829 2510 -1743
MVP -3502 7998 3433 6953
MYD88 1536 2750 4540 1945
MYH9 -3635 3380 2352 6144
MYO9B -2080 3138 4362 6775
NAPRT 214 -73 4098 -1869
NBEAL2 -2403 5606 4127 1726
NCF4 -2178 -141 4210 -1939
NCK1 3861 1096 -4123 1018
NCKAP1L 650 1928 4458 -320
NCKIPSD -3678 7993 -3134 667
NCSTN 1556 -453 4578 1224
NDUFC2 -2586 5313 2549 2881
NEU1 660 3057 4459 1899
NF2 54 981 522 1410
NFATC1 -3266 6729 -1906 6945
NFATC2 -2966 5180 -4600 7156
NFATC3 514 4876 -3772 1668
NFKB2 -128 2515 499 5250
NFKBIA -1959 3670 1551 6812
NFKBIB -4043 4651 2779 5572
NHLRC3 3852 5873 2633 4505
NIT2 2452 1153 -3459 -141
NKIRAS1 -1254 4201 -3568 348
NKIRAS2 -2892 2008 4410 -1130
NLRC5 -108 -233 1147 1905
NLRP1 -1719 7053 -761 3033
NLRP3 -16 6382 3342 -847
NLRX1 -4356 -359 4251 768
NME2 1390 1732 -173 -880
NOD1 702 2037 268 -321
NOD2 948 2355 4498 6608
NOS3 929 4038 -3056 4048
NPC2 2405 6347 2830 2198
ORMDL3 -3219 2570 -3756 3085
OSCAR 1666 2313 4583 7120
OSTF1 1009 7525 2469 6468
P2RX1 2272 2764 4586 -1947
PA2G4 1938 2826 -2412 5242
PAFAH1B2 2330 4486 909 2435
PAK1 3393 4953 4129 2452
PAK2 3060 2498 2198 283
PANX1 894 1287 2763 3960
PCBP2 -2726 1016 -881 3201
PDAP1 -4405 8096 3697 2952
PDPK1 -3330 144 2187 346
PDXK -1102 4954 2867 1492
PELI1 829 1534 725 1867
PELI2 -80 8419 1276 7033
PELI3 -4660 3884 4288 -1121
PFKL -4475 23 464 -1730
PGAM1 -1229 1586 4418 1307
PGM1 -3622 4559 1829 776
PGM2 1298 3342 3609 5133
PIK3CA 2884 3277 -475 1470
PIK3R1 -2132 5137 -4392 6991
PIK3R2 -2279 5345 2344 3831
PIK3R4 2189 2075 -1855 2170
PIN1 -4611 3766 76 4014
PKM -1111 1474 4062 3231
PLA2G6 -4368 2559 -2235 826
PLAC8 -1486 3803 4406 1235
PLAU -1912 5281 914 -1527
PLAUR 226 4310 4189 -861
PLCG1 -749 5789 -3949 958
PLCG2 -1458 6158 3982 2803
PLD1 2370 2188 4049 -902
PLD3 -2550 2237 2394 354
PLEKHO2 703 6284 4254 6697
PNP 823 2158 3217 3516
POLR1C 2228 2648 -3560 5328
POLR1D 804 3932 385 6780
POLR2E -4070 2983 1998 3712
POLR2F -4130 6520 2177 509
POLR2H -1987 7555 -1495 6297
POLR2K 3699 2452 -1615 3853
POLR3A 386 3837 301 5225
POLR3C 3386 7974 466 3978
POLR3D -2976 180 -3773 1967
POLR3E -4047 6433 -3136 1113
POLR3F 3336 7901 -2866 -1022
POLR3G 587 7022 -3591 6659
POLR3GL 192 230 -854 204
POLR3H -4544 6311 -4490 5544
POLR3K 926 708 710 891
PPIA -239 5602 -1924 4554
PPIE 1995 6743 -2167 6025
PPP2CA 2133 7688 1877 2598
PPP2CB 3173 15 2037 2771
PPP2R1B 1368 607 -1191 6169
PPP2R5D -1009 5720 986 3470
PPP3CA -123 1244 -187 5978
PPP3CB 4151 5256 913 4044
PPP3R1 579 5005 124 2945
PRCP 2944 6346 2835 611
PRDX6 -1247 4144 -345 5477
PRKACA -1378 3969 4529 890
PRKACB 559 7713 -4630 1712
PRKCD 301 8167 4500 6358
PRKCE -1194 7105 3475 -1183
PRKCQ -1185 3922 -4577 4207
PRKCSH -4486 5300 2163 4697
PRKDC -1551 8114 -2256 6474
PRTN3 -4653 8354 -2832 5619
PSAP 506 1283 3823 628
PSEN1 2104 1717 4209 4954
PSMA1 2917 5206 1363 4758
PSMA2 1509 4929 -836 5163
PSMA3 4416 1432 -1823 3586
PSMA5 3047 4175 -2828 3319
PSMA6 3897 6144 1661 6676
PSMA7 -246 5863 3266 6901
PSMB1 -371 2981 -803 5409
PSMB10 -3433 689 -161 6388
PSMB2 835 -501 1803 1518
PSMB3 23 780 3778 4305
PSMB5 -2694 183 3229 269
PSMB6 -3103 5638 3472 5817
PSMB7 -2378 1587 2955 4198
PSMB8 949 1746 2054 5155
PSMB9 -217 3058 -3454 4468
PSMC1 928 2242 2194 1413
PSMC3 -2624 4680 847 736
PSMC4 -1230 1188 537 3431
PSMC5 -1694 2039 -2600 5094
PSMC6 4108 118 1373 2356
PSMD1 2911 5546 2375 56
PSMD11 4009 2032 2637 3521
PSMD12 4511 5250 2167 3681
PSMD13 -998 7807 1482 561
PSMD14 3360 3896 85 6314
PSMD2 -3334 6719 2097 3610
PSMD3 -4637 3063 1629 5579
PSMD4 -1530 1685 3940 5313
PSMD6 1854 3171 3275 2336
PSMD7 3595 864 596 2079
PSMD8 -2435 7747 2069 4665
PSMD9 -3510 -186 3384 3375
PSME1 1353 7210 -2849 1614
PSME2 3304 7208 -1478 778
PSME3 802 6539 2470 5231
PSME4 3349 7885 -461 5908
PSMF1 -1946 2260 416 7179
PSTPIP1 -3181 2316 4195 680
PTGES2 -4318 -433 -1375 -901
PTK2 -814 2487 -1377 -475
PTPN11 -256 3762 1122 5061
PTPN4 -398 1836 -4481 784
PTPN6 -1174 2534 4395 6540
PTPRC 3660 1759 2823 -936
PTPRJ -2062 6860 3552 7167
PTPRN2 -1502 1639 -965 6583
PYCARD -1515 3142 4319 -1818
PYGB -3390 -229 -1259 141
QPCT 1033 1841 3998 -1472
QSOX1 -2300 6788 4519 5725
RAB10 2203 1022 4224 3067
RAB14 3720 1861 1150 -378
RAB18 4478 1161 1696 2764
RAB24 1932 257 4083 -168
RAB27A 3269 7260 2952 222
RAB37 -1677 7528 -2789 409
RAB3A -4569 3507 482 4347
RAB3D 604 5944 3885 1148
RAB4B -2727 7770 3909 4687
RAB5B -516 1208 1896 1957
RAB5C -2850 2984 3898 797
RAB6A 3034 6426 2839 3323
RAB7A 837 -522 3489 -124
RAC1 3574 7484 4225 5539
RAC2 -3760 6815 1945 4576
RAF1 537 4277 3739 6571
RAP1A 4512 2607 2624 6567
RAP1B 2749 6134 2033 5966
RAP2B -283 6562 394 5291
RASGRP1 500 3237 -4511 5886
RASGRP2 -3881 4893 -1986 -413
RBSN -2650 7872 -1916 6352
RELA -4376 5729 -1050 4332
RELB -1928 4179 2626 577
RHOA 2796 1879 3280 4033
RHOF -3403 3511 -4235 6476
RHOG -703 3967 4093 3664
RIPK3 1097 1791 4431 6793
RNASET2 -1180 732 3304 7087
RNF125 -499 4923 -4473 6174
RNF135 1671 2669 4476 -1613
RNF216 -3207 1260 -3286 4490
ROCK1 4037 2208 2623 2732
RPS27A -3731 2481 -4078 2589
RPS6KA1 -2393 6272 4241 -1857
RPS6KA2 -3185 6436 -715 2117
RPS6KA5 4173 7351 -3252 1991
S100A11 1465 3952 4310 6087
S100P -3641 627 3560 3303
SARM1 -3359 8141 -3432 4841
SCAMP1 2598 7802 -3481 2645
SDCBP 3311 7419 3605 3834
SERPINB1 990 -241 4236 -1477
SERPINB6 -3927 7977 3455 2823
SHC1 47 7294 2954 3205
SIGIRR -3514 8336 -2448 6805
SIKE1 3833 950 -2073 1675
SKP1 3454 3180 -2543 2680
SLC11A1 -326 1277 4588 4001
SLC15A4 -384 -645 3676 -1575
SLC27A2 3534 3271 -3276 -1409
SLC2A3 -2653 4133 3706 -1209
SLC44A2 -3555 1449 11 4322
SLCO4C1 838 1673 1214 -99
SNAP23 2642 7973 1694 -471
SNAP29 -4308 6060 3209 3148
SOCS1 3263 5646 2492 4130
SOS1 3053 3267 -1345 -1984
SPTAN1 -4171 369 -4508 -407
SRC -1769 -92 -2399 -1474
SRP14 2388 5802 1918 5762
STAT6 -2092 3383 4260 3854
STBD1 785 6119 -200 -658
STK10 -3634 3470 2725 -688
STK11IP -4178 4530 3990 2122
STOM 312 -756 1358 -1584
SUGT1 3689 6377 -97 5004
SURF4 -2330 5219 1962 3679
SVIP 2044 4128 -3340 1104
SYK 927 3885 3853 431
TAB2 1280 -849 -1462 6399
TANK 4486 5680 3220 6237
TAX1BP1 4184 1932 1345 1037
TBC1D10C -4516 3143 -3275 6910
TBK1 4522 6493 2094 599
TCIRG1 -2526 4545 4576 1353
TEC 1638 2871 4185 170
TICAM1 -372 1210 3650 1060
TIFA 1152 8170 -1422 4847
TIRAP -1492 3362 2573 1661
TLR1 2786 2626 3278 -1111
TLR2 3806 6774 4156 4128
TLR3 605 6769 -4494 2949
TLR5 1902 3910 4264 5699
TLR6 1146 -591 2855 -1199
TLR9 -3285 -405 -837 7201
TMBIM1 -3251 2134 3467 -47
TMC6 -3434 1580 -1994 6748
TMEM179B -176 1544 388 5595
TMEM30A 3654 7686 1750 6658
TMEM63A -691 1367 -3328 2620
TNFAIP3 -2738 1870 -572 6103
TNFRSF1B -1307 1250 4281 6868
TNIP2 -2442 793 2575 287
TOLLIP -3659 1231 2911 664
TOM1 -3899 5174 4227 4279
TRAF2 40 5279 -2998 5763
TRAF3 -3088 3505 -2224 7206
TRAF6 878 6544 -562 -71
TRAPPC1 -1916 3999 3336 5232
TREX1 1500 2324 592 -1434
TRIM21 3284 -41 2994 -1671
TRIM25 1951 6633 4223 446
TRIM56 1413 2971 -1165 5738
TRPM2 -2751 7757 4355 -1792
TSPAN14 -2003 917 4079 4962
TUBB -357 3701 -2272 6246
TUBB4B -2428 6398 2462 7160
TXK -3364 2757 -4527 4859
TXN 1873 336 3237 -1733
TXNDC5 2037 7500 -1760 -1871
TXNIP 4106 3959 -1903 6152
TYROBP -1849 830 4152 -1995
UBA3 4072 719 3656 4052
UBA52 -3208 4386 -596 -69
UBA7 -1691 3029 575 -1589
UBB -2084 561 -996 5058
UBC -1739 2624 1876 3220
UBE2D1 1930 4687 3454 2741
UBE2D2 -56 4255 -1159 2134
UBE2D3 3202 2444 2392 3005
UBE2K 3615 7162 1074 3260
UBE2L6 2934 760 -3002 1295
UBE2M -4705 5150 1539 2052
UBE2N 3397 6741 -1303 4833
UBE2V1 2034 4568 -1420 2792
UNC13D -3097 481 4403 -1904
UNC93B1 100 8116 4277 4748
VAMP8 -2659 3376 1656 868
VAPA 2045 3824 3031 4245
VAT1 -3926 1426 4292 -1357
VAV1 -2612 6923 3874 5832
VAV2 -832 7700 2796 4133
VAV3 -4054 8267 2141 -685
VCL -1153 1830 476 3614
VCP -2285 7849 1665 1908
VRK3 1695 5188 2478 2903
VTN -210 2502 1272 -1925
WASF1 -547 758 4502 -830
WASF2 -2160 1232 3929 -134
WASL 2751 7375 -567 4644
WIPF1 -2325 2893 -1463 -784
WIPF2 655 565 2515 -1017
XRCC5 1691 3512 -1013 1327
XRCC6 661 2803 -3543 3282
YES1 677 -619 -2471 5197
YPEL5 1717 -147 2447 3986
ZBP1 3229 515 -2798 7174





Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
metric value
setSize 86
pMANOVA 1.31e-24
p.adjustMANOVA 2.98e-24
s.dist 0.689
s.t0_crp_RNA -0.407
s.t0_crp_meth -0.0542
s.pod_crp_RNA -0.511
s.pod_crp_meth 0.215
p.t0_crp_RNA 7.72e-11
p.t0_crp_meth 0.387
p.pod_crp_RNA 2.86e-16
p.pod_crp_meth 0.000578



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA t0_crp_RNA
RPS2 -4571 -4698
RPL3 -4610 -4508
RPLP2 -3815 -4667
RPS5 -4065 -4113
RPS12 -3896 -4261
RPLP0 -4060 -4068
RPL27A -3904 -4061
RPS3 -4143 -3753
RPS27A -4078 -3731
RPS16 -3448 -4379
RPL29 -3643 -3990
RPS10 -3457 -4168
RPL37 -2971 -4723
RPL35 -3508 -3999
RPS29 -3034 -4598
RPS18 -3284 -4218
RPS6 -4317 -3204
RPL18A -3444 -3938
RPS23 -3858 -3376
RPL38 -2941 -4417

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
CASC3 -2211 3328 2647 5105
DCP1A 2646 4253 -3323 5068
EIF4A3 -2476 5309 -384 4597
EIF4G1 -3029 3207 3785 5764
ETF1 3017 7097 1676 151
FAU -4223 5971 -437 6875
GSPT1 2757 4351 -2932 -1153
NCBP1 4110 6523 -472 5857
NCBP2 4266 3714 -3787 4776
PABPC1 1721 3723 -1442 3011
PNRC2 4481 3773 -2191 5676
PPP2CA 2133 7688 1877 2598
PPP2R2A 4508 542 -554 -752
RNPS1 -2473 2186 -3151 537
RPL10A -2021 3601 -3665 3590
RPL11 -2195 4759 -3631 -495
RPL13 -2399 2561 -2415 6187
RPL13A -2217 1446 -4059 5521
RPL14 -2732 1645 -4433 -798
RPL15 -2979 2857 -3337 1424
RPL17 -3043 1594 -3926 2296
RPL18 -3380 7714 -3552 4478
RPL18A -3938 751 -3444 4254
RPL22 -2825 5674 -4182 1020
RPL23 -1858 5701 -3100 2729
RPL23A 48 7818 -4430 4559
RPL26 -2272 4855 -3465 6407
RPL26L1 -972 2107 2314 3971
RPL27A -4061 5311 -3904 1697
RPL28 -2225 2129 -798 4754
RPL29 -3990 4921 -3643 2875
RPL3 -4508 360 -4610 6751
RPL31 -3651 495 -3411 -34
RPL32 -3564 4776 -3623 5998
RPL34 -904 906 -3944 6513
RPL35 -3999 2909 -3508 4823
RPL36 -4523 -158 -2815 2877
RPL36AL -4195 7236 -1732 6350
RPL37 -4723 3433 -2971 5392
RPL37A -3969 1847 -2033 4981
RPL38 -4417 4342 -2941 4430
RPL39L -2468 4218 -28 5079
RPL4 -2456 997 -4254 1394
RPL41 -3631 4792 -2682 821
RPL6 466 3352 -3950 1979
RPL7 -2841 5004 -4292 7008
RPL8 -4442 7620 -2781 5093
RPL9 -990 4307 -3377 844
RPLP0 -4068 5078 -4060 4850
RPLP1 -4307 4259 -1607 1521
RPLP2 -4667 3685 -3815 6421
RPS10 -4168 2356 -3457 3925
RPS11 -3884 1199 -3013 4224
RPS12 -4261 7672 -3896 6329
RPS15 -3350 1899 -2308 5621
RPS15A -3437 1657 -3621 6110
RPS16 -4379 4270 -3448 5979
RPS18 -4218 4809 -3284 4162
RPS19 -3954 1402 -2451 -362
RPS2 -4698 -704 -4571 6973
RPS20 -1234 4742 -3936 3461
RPS23 -3376 -353 -3858 2986
RPS24 -35 6157 -2288 -518
RPS25 -2395 138 -4129 1797
RPS26 -1529 6099 -2398 5515
RPS27A -3731 2481 -4078 2589
RPS27L 3563 2925 1087 1405
RPS28 -4025 17 -2863 -1178
RPS29 -4598 3919 -3034 5600
RPS3 -3753 4053 -4143 4598
RPS3A 1196 4024 -4365 7066
RPS5 -4113 3314 -4065 6070
RPS6 -3204 4732 -4317 361
RPS7 -2809 3926 -3695 4407
RPS8 -1253 -347 -3213 -79
RPS9 -3353 1940 922 627
RPSA 1973 687 -1923 2072
SMG1 55 8307 -687 4788
SMG5 -2955 -215 -767 5172
SMG6 -2359 -678 -1874 6205
SMG7 1612 3107 3551 2361
SMG8 2347 7988 255 1691
UBA52 -3208 4386 -596 -69
UPF1 -2902 707 2612 5956
UPF2 3948 4005 -99 3840
UPF3A -1847 6389 -3579 6961





Immune System

Immune System
metric value
setSize 1142
pMANOVA 3e-22
p.adjustMANOVA 5.99e-22
s.dist 0.184
s.t0_crp_RNA 0.0358
s.t0_crp_meth -0.0112
s.pod_crp_RNA 0.176
s.pod_crp_meth 0.0349
p.t0_crp_RNA 0.0495
p.t0_crp_meth 0.538
p.pod_crp_RNA 3.52e-22
p.pod_crp_meth 0.0555



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA t0_crp_RNA
WSB1 4190 4440
C3AR1 4547 4000
MX2 4101 4270
IDH1 4526 3628
LMNB1 4311 3711
TLR2 4156 3806
CD58 3835 4062
DCTN6 3502 4349
RAC1 4225 3574
SP100 3388 4417
SLA 3680 4046
UBA3 3656 4072
KLHL2 4184 3485
LGALS9 4298 3366
TANK 3220 4486
ADAM17 4464 3217
DNAJC13 3651 3873
PAK1 4129 3393
OASL 3095 4406
IFNGR1 3984 3407

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
A1BG -4720 7280 525 567
AAAS -638 2718 243 1467
AAMP -4607 1163 -1372 7118
ABCE1 3662 2890 -4608 6004
ABI1 4121 520 2868 3253
ABI2 570 1453 -3567 -206
ABL1 -3241 5957 1585 2469
ABL2 -280 4972 -684 5307
ACAA1 -1087 6265 4528 5788
ACLY -1395 2347 3652 2976
ACTB -373 4248 4005 5446
ACTG1 -3456 6407 3191 1603
ACTR10 2603 5113 1646 4867
ACTR1A -1288 879 3846 1932
ACTR1B -3875 3798 -2148 2629
ACTR2 3144 4932 2747 3844
ACTR3 2753 4481 2482 5950
ADAM10 2914 3590 3423 2760
ADAM17 3217 4696 4464 4154
ADAM8 -2204 7454 2256 5096
ADAR 2970 5925 1386 3087
ADGRE5 -2627 2052 3671 -1468
AGA -2883 -401 -2619 2162
AGL 2065 2754 -959 1016
AGPAT2 -3761 -328 4455 -1386
AHCYL1 1297 6888 1605 2692
AIM2 2677 -558 720 -1275
AIP -4146 1494 -31 6682
AKT1 -4471 4213 2297 1109
AKT2 -4622 3462 2041 5430
ALAD -4161 371 4014 1057
ALDOA -1859 643 4238 5366
ALDOC -367 7284 -2691 65
ALOX5 330 6127 4345 5385
AMPD3 -1687 4553 3545 3216
ANAPC1 -1080 3338 -4436 2990
ANAPC10 2049 -304 48 -1324
ANAPC11 -4132 7036 1733 3188
ANAPC13 2519 2410 -1936 493
ANAPC2 -4276 1380 -883 2865
ANAPC4 4253 1488 341 -687
ANAPC5 1471 3129 -1620 5212
ANAPC7 4117 862 1103 1873
ANO6 -849 7646 -21 1102
AP1B1 -3672 7580 4242 5781
AP1G1 1620 6342 1504 2214
AP1M1 -4217 2143 3873 1777
AP1S3 938 5055 686 1942
AP2A1 -2927 1888 4575 -316
AP2M1 -4018 5714 2737 3723
AP2S1 -1597 3981 3589 6037
APAF1 1473 7512 2266 -809
APEH -3872 429 1730 832
APP -1029 7569 1303 6621
APRT -4283 7658 -2811 2643
AREL1 -694 2081 3585 5152
ARF1 -3573 8373 3973 -1819
ARHGAP9 -2519 389 4113 6255
ARIH1 2666 5821 -1008 3751
ARIH2 -3057 1230 -3373 3734
ARL8A -3571 135 3462 -1057
ARMC8 3399 4263 67 2641
ARPC1B -3236 2831 4244 1709
ARPC2 1775 5683 3457 2292
ARPC3 2785 4820 3580 3208
ARPC5 2109 2335 3836 2611
ARSA 1972 -580 3635 523
ARSB 1416 6851 3997 -1526
ASAH1 2991 3487 4461 2174
ASB1 -3201 -377 3505 6029
ASB13 401 6720 -773 1754
ASB2 -2074 -447 -2489 6211
ASB6 -2439 2646 1941 -1068
ASB7 -758 3722 -1329 6527
ASB8 695 929 989 5452
ATAD3B -3224 5569 -2736 4810
ATF1 4365 685 1579 2989
ATG12 4083 4620 -2436 6821
ATG5 4418 1135 -2277 -680
ATG7 2082 1256 2282 3847
ATOX1 -2402 7999 2468 390
ATP11A -1708 5464 4170 132
ATP11B 1100 -213 1786 -241
ATP6V0A1 -73 5522 4481 -1569
ATP6V0A2 1039 5229 -2100 6651
ATP6V0B -2906 4920 4040 5502
ATP6V0C -819 2497 4204 2933
ATP6V0D1 -717 5801 4411 6934
ATP6V0E1 -98 5534 3098 1836
ATP6V0E2 688 -8 -3868 -1325
ATP6V1A 2260 3916 3165 -1495
ATP6V1B2 1335 2965 3679 -1553
ATP6V1C1 3195 3435 3307 6757
ATP6V1D 3158 446 3682 1096
ATP6V1E1 3127 6210 2844 4775
ATP6V1F -2969 2955 1967 -699
ATP6V1G2 -783 7744 -3696 3740
ATP6V1H 2094 5695 1932 2559
ATP8A1 -1321 -197 -4498 -913
ATP8B4 80 -467 612 -1099
B2M 3496 3645 -3314 -9
B4GALT1 -2606 7929 1953 7041
BAIAP2 -3214 6287 -510 2757
BATF -1671 2924 1438 6677
BCL10 3129 6246 1603 2575
BCL2 891 55 -3102 7020
BCL2L1 168 5903 -129 5968
BCL2L11 72 5304 2972 5662
BCL6 -1059 973 4510 3669
BIN2 -3373 3302 4006 5389
BIRC2 4449 4494 -741 6624
BIRC3 3504 588 -4618 4816
BIRC5 2315 6240 -142 1965
BLMH 738 1330 -1570 -120
BRI3 -1874 3754 4413 -1176
BRK1 -4091 8027 -825 3071
BRWD1 817 -90 -2860 -349
BST2 1250 -703 383 -1933
BTBD1 3809 4362 -1966 120
BTBD6 -4485 1663 -3446 3006
BTN2A1 3255 2288 1451 1617
BTN2A2 776 6643 -2397 108
BTN3A1 2243 3036 -2606 1278
BTN3A2 -1663 5782 -4090 3317
BTN3A3 416 3557 -3440 6402
BTRC -2069 66 -3130 -923
C3AR1 4000 1722 4547 -1594
C6orf120 -845 7883 319 3829
C8G -1876 4665 114 -1364
CAB39 2427 -206 2233 7106
CALM1 1287 3980 -2201 4501
CALR 1148 3542 1904 5712
CAMK2D -1499 3793 -4469 -529
CAMK2G 943 31 471 6716
CAND1 2021 1725 -3244 2163
CANX 1285 7328 -533 3479
CAP1 497 5559 3138 2034
CAPN1 -3906 5471 3918 1819
CAPZA1 4166 7801 2992 999
CAPZA2 3798 3735 2976 4666
CAPZB -747 3052 3210 -308
CARD11 -3851 5791 -4243 6542
CARD9 -3315 -774 3670 -1761
CASP1 4199 -379 2331 7029
CASP10 2029 1610 1690 -1805
CASP3 4360 3118 1576 5689
CASP4 3211 507 2271 -96
CASP8 2071 5784 -2229 5447
CASP9 110 698 4367 3202
CAT 282 -220 3549 -1204
CBL -1090 7589 3285 1012
CBLB -2176 3114 -4258 343
CCND1 -2434 3555 -1529 1006
CCNF -988 3827 -1935 392
CCR1 2329 4664 3112 -1919
CCT2 1454 3443 -4591 194
CCT8 2610 2003 -111 2904
CD247 -4182 3160 -4496 6034
CD274 2935 -9 -3362 -305
CD300A 2225 -861 4103 -1998
CD3D 799 -531 -4088 7271
CD3E 2250 -641 -4427 7190
CD4 -528 5984 -2076 909
CD44 498 4392 3154 4897
CD46 4402 5368 2807 5538
CD47 2166 2442 -3816 6601
CD53 2247 -462 3926 6482
CD55 1738 3285 4145 1455
CD58 4062 5810 3835 -611
CD59 -1703 4468 -1328 -1682
CD63 -2910 7177 4520 5433
CD74 -1224 -79 -2623 -648
CD79B -2270 5017 -3176 -1165
CD81 -2406 2412 -2059 3296
CD96 -1754 1424 -4660 6876
CDC16 1700 7029 -672 3340
CDC20 -670 5825 -791 2639
CDC23 3736 4379 -3706 1597
CDC34 -4179 6224 2873 -408
CDC42 3320 7040 2741 856
CDK13 -2241 5468 9 5777
CDKN1A 1249 7552 1225 2427
CDKN1B -532 1651 -3401 3367
CEACAM1 -237 822 1684 5458
CEBPD -2296 1317 3893 -907
CENPE 4361 2608 751 -74
CEP290 4268 7316 -2743 7000
CFL1 -3249 4059 3672 1646
CHUK 2695 2702 2681 1111
CISH 3901 4706 292 4927
CKAP4 -813 8287 3854 -987
CLEC2B 2572 2977 -2710 2668
CLTA 185 1469 2876 -546
CLTC 461 2670 3511 7256
CMTM6 3583 4072 2869 1926
CNN2 -1565 2034 1954 -418
CNPY3 -2430 3188 3017 1242
COMMD3 3610 606 665 -1960
COMMD9 1680 85 3383 2239
COPB1 4354 2889 2313 2637
COTL1 671 2421 4276 6759
CPNE1 -1872 4807 -478 5131
CPNE3 1598 2499 -94 -1441
CPPED1 340 5747 4044 -641
CRCP 998 6155 1033 4707
CREB1 2387 5046 -1542 1422
CREBBP -4011 6807 2122 892
CREG1 -2492 1563 2917 -1059
CRK 3068 5936 3523 6596
CRKL -1398 7466 -102 5166
CSF1 916 1541 -2144 356
CSK -2994 1998 3950 4889
CSNK2B 63 7476 2450 4742
CSTB 469 6900 4229 2893
CTF1 -2377 7037 825 543
CTLA4 -1839 -754 -2871 7088
CTNNB1 2009 6708 3025 5069
CTSA -2481 2086 4047 2720
CTSB 83 7057 4475 -965
CTSC 2238 2310 3599 1311
CTSD -3067 8404 4479 6620
CTSL 873 8363 4377 3028
CTSO 2777 7410 -3278 5110
CTSS 2274 -506 2686 -1544
CTSV -308 7141 -258 5169
CTSZ -1191 -74 4162 -1978
CUL1 4355 1572 -4161 -1190
CUL2 4307 5990 178 2207
CUL3 1497 3752 642 -873
CUL5 4190 5397 -1036 344
CUL7 -2371 2156 2841 6186
CXCL2 -4220 7587 1113 -1988
CYB5R3 -4015 4980 3732 3239
CYBA -2911 5359 4087 2019
CYFIP1 644 8297 4331 256
CYFIP2 -1585 4227 -2032 6157
CYLD 1079 5350 -4487 5704
CYSTM1 594 7301 3572 -1740
DAPP1 3557 7887 182 6836
DBNL -4518 2964 3614 -406
DCTN2 -3591 -463 4022 -727
DCTN3 -2237 4070 2936 2751
DCTN4 3328 3748 3561 4416
DCTN5 -4299 7627 -377 6058
DCTN6 4349 6414 3502 6880
DDX41 -4055 5715 1011 4425
DDX58 4465 2907 -3747 185
DEGS1 -1317 4783 -164 3203
DERA 3518 7409 3669 3602
DET1 2062 4399 -2294 122
DGAT1 -3399 6428 2057 -576
DHX36 3868 1789 -1657 6438
DHX58 3998 1444 -1341 -30
DHX9 243 6405 -2418 5545
DIAPH1 -659 5118 910 2371
DNAJC13 3873 207 3651 408
DNAJC3 2858 8289 3092 6470
DNAJC5 -2985 3110 3776 -1396
DNM1 2874 2154 2211 1607
DNM2 -4239 6583 3699 3063
DPP7 -4644 7245 -1735 6584
DSN1 2407 2698 -1398 -996
DTX4 -4129 5372 3400 5143
DUSP3 -328 6561 3398 2260
DUSP4 1176 3581 -1089 2494
DUSP6 -534 7727 -1313 -1941
DUSP7 -2585 6442 -1315 722
DYNC1H1 -2872 1165 -441 4433
DYNC1I2 3141 258 2171 693
DYNC1LI1 3353 6061 2935 3242
DYNC1LI2 1369 3124 3014 -185
DYNLL1 -405 5371 1250 5150
DYNLL2 -3503 3295 -3679 -924
DYNLT1 2953 4660 2802 5599
DZIP3 391 378 -4227 -958
ECSIT -1973 6302 1201 1450
EDARADD 1265 7621 -3682 6839
EEA1 3244 1440 -457 5334
EEF1A1 -3462 2007 -4432 2941
EEF2 -4680 1309 -3170 4195
EGR1 -4716 7086 -3070 1893
EIF2AK2 4506 187 169 683
EIF4A1 568 5332 2238 881
EIF4A2 3750 5307 -4415 3601
EIF4A3 -2476 5309 -384 4597
EIF4E 4474 5594 818 6719
EIF4E2 -432 2798 2567 5874
EIF4E3 4105 -720 3038 -661
EIF4G1 -3029 3207 3785 5764
EIF4G2 1621 6211 552 6371
EIF4G3 -331 893 4056 1034
ELMO1 -2007 4440 -587 939
ELMO2 2276 3622 3753 6108
ENPP4 1515 1338 -2234 3170
EP300 -1082 3351 3310 4900
ERAP1 -2570 2680 -1115 1806
ERAP2 3962 4 2368 -756
ERP44 3533 127 1159 920
EVL -2581 3789 -3990 7073
FABP5 1248 3657 2416 2233
FADD -32 2272 2169 -329
FAF2 230 7630 1614 2842
FBXL12 -3258 945 196 4059
FBXL14 -4389 1537 -2683 6754
FBXL15 -2923 3574 1356 970
FBXL16 -4026 7450 -4623 6376
FBXL18 -948 5478 2834 853
FBXL19 -3282 7568 4517 -220
FBXL20 3871 7030 2442 1213
FBXL22 -2807 7779 -2664 5650
FBXL3 2952 7436 -2105 2065
FBXL4 3807 3684 1020 1511
FBXL5 3400 6904 3439 6718
FBXL8 -3113 7487 -426 5372
FBXO11 4419 1968 1922 7062
FBXO15 3435 5306 1026 2131
FBXO21 1051 4757 -3028 6288
FBXO22 4322 1300 461 -930
FBXO30 3411 6130 -576 1907
FBXO31 -2815 5960 -4612 4755
FBXO32 -2830 6776 -4547 6486
FBXO4 1020 4804 -4282 106
FBXO6 235 75 3428 92
FBXO7 1953 2193 -93 2923
FBXO9 2621 5830 4508 3195
FBXW11 -1449 8406 480 -1506
FBXW2 1823 709 3786 2654
FBXW4 -95 1675 -3195 136
FBXW5 -4477 -593 1507 -1870
FBXW7 1395 6293 -812 6665
FBXW8 -2672 2431 -2647 4558
FGR -1601 6431 4539 -1074
FKBP1A 2460 6115 3110 1814
FLNB -2802 3880 2494 675
FLT3LG -2752 4449 -4476 6675
FOS -4562 4067 -1568 5645
FOXO1 -3602 816 -4632 3034
FOXO3 -3051 7309 2545 5022
FTH1 -378 3718 2380 3117
FTL 609 3955 3972 -1424
FUCA1 -689 2325 2425 1656
FUCA2 1128 614 2428 -1234
FYN -2118 2799 -2956 2793
FZR1 -3205 7403 689 2326
GAA -1924 1082 3079 2768
GAB2 -2692 347 3912 2390
GALNS -2319 6550 3709 3670
GAN 305 4487 362 3655
GATA3 -395 8146 -4535 6272
GBP3 2699 7680 -3061 89
GCA 3226 2697 4151 5559
GDI2 3001 7874 2004 3343
GGH 2821 6701 1044 3861
GHDC -3703 2847 1243 -571
GLB1 890 7186 4196 1828
GLIPR1 3846 390 2195 5591
GLMN 4382 7415 -3770 -22
GM2A 2719 6404 4388 6361
GMFG 254 6320 3611 6367
GNS 1404 5454 4533 4428
GOLGA7 1327 3410 -2030 3104
GPI -2280 6574 1799 5672
GRAP2 -2746 6230 -2761 3631
GRB10 561 190 4532 3328
GRB2 29 5972 4230 6239
GRN -475 3078 4312 4937
GSDMD -2417 4172 1671 -91
GSTO1 347 7221 3900 3633
GSTP1 -976 6809 683 -1350
GUSB -2488 4868 4470 2338
GYG1 -319 6447 3938 -231
GZMM -3093 -219 -3628 7249
HACE1 1927 5481 -841 -395
HCST -3713 2904 521 1324
HEBP2 -1887 5561 2156 552
HECTD1 -719 4129 185 5899
HECTD3 -797 7407 3479 463
HERC1 480 3575 -1171 1913
HERC3 772 3454 1230 3912
HERC4 4524 -156 1233 232
HERC5 4477 1222 -3630 -1037
HEXB 1519 7559 2594 2906
HGSNAT -63 352 -1489 3342
HIF1A 1346 4099 2872 2448
HLA-A -4080 2266 -2368 -1093
HLA-B -821 510 896 -730
HLA-C 51 6767 1218 4448
HLA-DMA 869 1536 -1299 -1926
HLA-E -950 3730 -1002 5634
HLA-F -3752 -24 -904 2974
HLA-H -4350 7821 -546 4988
HMGB1 1943 2521 -3489 3222
HMOX2 -3769 699 -4339 6411
HNRNPA2B1 1271 2586 2367 2721
HNRNPF -3188 3524 -532 5855
HRAS -3453 1483 -1282 -823
HSP90AA1 3100 4857 -2176 6208
HSP90AB1 1227 824 -4305 -1224
HSP90B1 4301 7702 -1893 2127
HSPA1A -3490 1106 2517 -920
HSPA1B 1576 750 1718 655
HSPA9 -243 5862 -4493 6549
HVCN1 -951 1427 1485 -385
ICAM1 -1757 6181 1880 2036
ICAM2 -608 980 -4564 4818
ICAM3 -4729 900 2016 6838
ICAM5 -1816 7084 4495 4185
ICOSLG -1952 8090 -2193 4496
IDH1 3628 3280 4526 3454
IFI30 2632 3541 4450 -1602
IFI35 3572 205 3006 1292
IFI6 3862 913 967 5535
IFIH1 4466 4707 -2544 2681
IFIT1 4407 25 -3881 312
IFIT2 4291 -226 -3900 1477
IFIT3 4438 7094 -2788 6159
IFIT5 4463 7233 -4089 3745
IFITM1 1081 813 -1754 6983
IFNAR1 2671 6039 3008 1219
IFNAR2 -1339 1943 3116 1115
IFNGR1 3407 4319 3984 4124
IFNGR2 2871 6499 4530 4230
IGF2R -4041 -23 3850 -1657
IKBKB -1861 958 1970 -912
IKBKE -39 5956 3231 6703
IL10RA -2658 3506 605 5516
IL10RB 2492 1088 4296 -1075
IL12A 1447 2118 -2780 -1315
IL12RB1 -2291 -670 -1696 6630
IL12RB2 -4567 1065 -4043 -1859
IL15 1769 6831 1135 3611
IL15RA 3307 3533 2179 -1086
IL16 -3248 4110 -2267 5457
IL17C -2577 -487 3055 -1128
IL17RA 388 5913 4322 130
IL17RC -3722 7073 -539 1939
IL18BP 1389 -326 316 -1638
IL18R1 -2304 7423 850 6742
IL19 2005 -683 2850 7263
IL1RAP 2063 39 2084 -1120
IL21R -2031 2004 -3090 2722
IL23A 1948 -668 -4551 7076
IL27RA 295 4390 2711 6657
IL2RA 1014 432 -3039 6866
IL2RB -4721 5850 -4587 7234
IL32 616 212 -4349 7265
IL4R -494 -410 3746 1274
IL6R -583 6529 1258 5065
IL6ST 3221 3452 -1202 1708
ILF2 2531 -350 -1689 2770
IMPDH1 -1286 6 4428 2600
IMPDH2 -3789 5334 -4679 250
INPP5D -3830 1160 2964 55
INPPL1 -2826 7266 4370 588
IP6K2 1553 7287 744 799
IQGAP1 -6 372 3381 587
IQGAP2 2140 2768 3344 3888
IRAK2 -3547 7809 -2980 4685
IRAK3 1420 2776 4357 666
IRF1 302 5434 -2536 5830
IRF2 3372 5303 2864 2365
IRF3 -2649 2791 -1301 4240
IRF4 2179 4585 -3146 5939
IRF5 -223 8174 2710 -1649
IRF7 2494 6595 3230 3556
IRF9 4132 5108 884 4774
IRS1 -4535 4409 -2997 4307
IRS2 -4076 5285 3498 6150
ISG15 3651 -537 -3046 6539
ISG20 -143 -116 -2935 7058
IST1 2520 1926 2863 1014
ITCH 421 6841 732 4853
ITGA4 1894 4646 -3651 -394
ITGAL -1994 4404 1129 7036
ITGAV 2010 3274 3023 -370
ITGB2 -4211 745 4253 6424
ITGB7 2421 362 -3588 -1689
ITK -839 -349 -4350 -1699
ITPR1 -1901 6612 -1565 1789
ITPR2 1162 4456 2298 -44
ITPR3 -748 2875 -2503 2189
JAK1 -3630 6963 -3720 -283
JAK2 4309 6228 1486 6487
JUN -3724 2763 -598 1283
JUNB -4339 4464 541 5017
KBTBD6 541 5636 -1355 80
KBTBD7 1063 6403 893 -381
KBTBD8 1753 665 -760 834
KCMF1 1322 -488 1586 3310
KCNAB2 -4643 5909 2760 -600
KCTD6 2713 7603 2328 -621
KCTD7 -1407 7819 -3875 1682
KEAP1 -3069 5029 2242 1379
KIF11 2296 7352 -1688 1895
KIF15 1694 6303 -1340 6307
KIF18A 2515 2110 32 3290
KIF20A 627 -149 -591 1403
KIF22 -1338 3577 -4145 6181
KIF23 1258 2564 1959 805
KIF2A -2414 107 -3921 4006
KIF2C 3056 5593 433 -12
KIF3A 1773 3240 -4199 6172
KIF3B 765 1867 1704 2018
KIF3C -3143 2102 1672 -1428
KIF5B 3638 7491 2378 4669
KIFAP3 3661 5881 -2260 -68
KLC1 -2743 7465 2962 4385
KLC2 -1865 5384 -1364 1505
KLC4 -2811 2807 -494 4366
KLHL11 -3410 7014 -1379 5348
KLHL2 3485 5667 4184 6409
KLHL20 1080 2462 -2537 1429
KLHL21 -4647 2533 -395 5915
KLHL22 -4131 2637 -3639 1129
KLHL25 -4483 2495 -4514 4488
KLHL5 718 2938 -2940 3248
KPNA1 2982 6152 -1803 4422
KPNA2 2320 838 -1587 4420
KPNA3 3326 1397 -1791 4399
KPNA4 3677 8123 -297 4999
KPNA5 3718 1682 -3426 1847
KPNB1 2659 5901 -47 1140
KRAS 4442 4004 1217 3139
LAIR1 -901 6730 4482 3425
LAMP1 -4014 7954 3219 2553
LAMTOR1 -4534 -643 3758 -1587
LAMTOR2 -3989 -286 3497 -1340
LAMTOR3 3368 6744 792 957
LAT2 -1732 6599 4173 -1714
LCK -1825 2493 -4488 7243
LCP1 1687 4158 3798 4311
LCP2 2815 -273 200 -428
LGALS9 3366 3238 4298 -1460
LGMN -2484 6373 -3917 2706
LIMK1 -3358 -627 3471 -1748
LMNB1 3711 4088 4311 1051
LMO7 -3850 7894 -4172 7259
LNPEP 1126 2921 -1545 2406
LONRF1 905 4500 3456 6151
LPCAT1 -2710 -419 1992 1418
LRR1 819 8304 -2604 3790
LRRC41 -454 1095 4215 2878
LRRFIP1 3522 4814 3045 5296
LRSAM1 1862 7458 3833 5942
LTA 2971 -622 -4104 7253
LTA4H 2233 5699 4301 798
LTB -2128 4959 -4443 5584
LTN1 2994 -772 -1685 7195
MALT1 633 7648 -4558 2545
MAN2B1 -2647 7254 2518 6387
MANBA 3782 4762 2996 6844
MAP2K1 -1421 -148 3921 1533
MAP2K3 -2498 38 3714 2411
MAP2K4 1784 3155 1767 4763
MAP2K6 3151 2164 3939 4791
MAP2K7 -4193 2092 431 1764
MAP3K1 1458 3815 1771 2247
MAP3K14 -2001 1381 -3221 4220
MAP3K3 -3332 2306 4125 3121
MAP3K7 2692 3839 1057 -147
MAP3K8 826 6359 4551 3266
MAPK1 -745 2758 4197 6097
MAPK14 1563 2227 4024 2465
MAPK3 -4620 -475 3649 1978
MAPK7 -2209 3007 3966 -244
MAPK8 -1037 6156 -3737 4553
MAPK9 -260 1152 -2605 157
MAPKAP1 1208 5508 898 5906
MAPKAPK2 -3939 1416 2421 3265
MAPKAPK3 -1142 58 4580 2896
MAVS -3312 5447 2245 4280
MEF2A 2271 7441 3276 3013
MEX3C -3854 4091 -4532 6167
MGRN1 -3170 2839 3860 -1403
MICA -120 6694 -319 3105
MICB -79 3279 3613 3131
MIF -3715 2437 -3047 3355
MKRN1 84 7896 951 2197
MLEC -1358 5314 -1498 2183
MLST8 -2723 3408 89 2258
MMP25 -966 6396 4100 6852
MNDA 3361 1442 3506 -1994
MPO -3878 344 -3645 -1967
MRC2 -1341 7047 -1053 -577
MT2A 493 3765 33 1186
MTAP 2432 8029 -2882 2271
MTOR -3867 1233 454 3900
MUC1 -1022 6782 2987 6713
MUC12 3257 3997 -166 4640
MUC5B 758 -829 2510 -1743
MVP -3502 7998 3433 6953
MX1 4155 1144 -2305 -1015
MX2 4270 -240 4101 1798
MYD88 1536 2750 4540 1945
MYH9 -3635 3380 2352 6144
MYLIP -1998 4478 -3408 2479
MYO9B -2080 3138 4362 6775
NAPRT 214 -73 4098 -1869
NBEAL2 -2403 5606 4127 1726
NCF4 -2178 -141 4210 -1939
NCK1 3861 1096 -4123 1018
NCKAP1L 650 1928 4458 -320
NCKIPSD -3678 7993 -3134 667
NCSTN 1556 -453 4578 1224
NDC1 -28 -272 -4667 6480
NDUFC2 -2586 5313 2549 2881
NEDD4 2622 6200 3146 -1104
NEDD4L -2331 220 3504 -1079
NEU1 660 3057 4459 1899
NF2 54 981 522 1410
NFATC1 -3266 6729 -1906 6945
NFATC2 -2966 5180 -4600 7156
NFATC3 514 4876 -3772 1668
NFKB2 -128 2515 499 5250
NFKBIA -1959 3670 1551 6812
NFKBIB -4043 4651 2779 5572
NFKBIE 2782 952 -992 4746
NHLRC3 3852 5873 2633 4505
NIT2 2452 1153 -3459 -141
NKIRAS1 -1254 4201 -3568 348
NKIRAS2 -2892 2008 4410 -1130
NLRC5 -108 -233 1147 1905
NLRP1 -1719 7053 -761 3033
NLRP3 -16 6382 3342 -847
NLRX1 -4356 -359 4251 768
NME2 1390 1732 -173 -880
NOD1 702 2037 268 -321
NOD2 948 2355 4498 6608
NOS3 929 4038 -3056 4048
NPC2 2405 6347 2830 2198
NUP107 2943 1017 -4115 6299
NUP133 2030 1473 -2474 935
NUP153 1372 7264 -1870 4343
NUP155 1163 5083 -3460 3043
NUP160 1232 5781 -4066 1293
NUP188 -2474 591 -3287 2922
NUP205 1308 370 -3162 1670
NUP210 -4099 775 -1841 690
NUP214 779 7322 3866 4368
NUP35 3287 7567 -4566 -557
NUP37 1488 500 -594 3398
NUP43 3972 139 -3557 6344
NUP50 2599 5772 -517 6704
NUP54 4432 6517 -2306 831
NUP62 -1277 2703 156 4608
NUP85 2428 5395 -713 4517
NUP88 1692 6430 -4454 7082
NUP93 1140 7850 -1307 2006
NUP98 808 1649 64 -747
OAS1 4069 -193 1675 -1505
OAS2 4422 3120 -3241 6616
OAS3 3858 5403 -3256 616
OASL 4406 6399 3095 5927
ORAI1 -3662 2145 -3206 2153
ORAI2 -2396 -391 2252 -132
ORMDL3 -3219 2570 -3756 3085
OSCAR 1666 2313 4583 7120
OSM -4108 1297 161 1355
OSTF1 1009 7525 2469 6468
P2RX1 2272 2764 4586 -1947
P4HB -3022 6808 3555 5716
PA2G4 1938 2826 -2412 5242
PAFAH1B2 2330 4486 909 2435
PAG1 -2026 5032 128 6277
PAK1 3393 4953 4129 2452
PAK2 3060 2498 2198 283
PANX1 894 1287 2763 3960
PCBP2 -2726 1016 -881 3201
PDAP1 -4405 8096 3697 2952
PDCD4 3138 54 -4445 4219
PDE12 3461 -499 -1337 6081
PDIA3 1626 1035 1128 4845
PDPK1 -3330 144 2187 346
PDXK -1102 4954 2867 1492
PELI1 829 1534 725 1867
PELI2 -80 8419 1276 7033
PELI3 -4660 3884 4288 -1121
PFKL -4475 23 464 -1730
PGAM1 -1229 1586 4418 1307
PGM1 -3622 4559 1829 776
PGM2 1298 3342 3609 5133
PIAS1 4489 7666 1762 2845
PIK3AP1 131 4960 4137 1373
PIK3CA 2884 3277 -475 1470
PIK3CD -4035 151 2426 6107
PIK3R1 -2132 5137 -4392 6991
PIK3R2 -2279 5345 2344 3831
PIK3R3 2060 3520 1094 3645
PIK3R4 2189 2075 -1855 2170
PILRB -2504 7827 -1429 2683
PIM1 -708 2982 1290 1390
PIN1 -4611 3766 76 4014
PITPNA 512 1692 3198 3616
PJA2 1859 7717 2299 2112
PKM -1111 1474 4062 3231
PLA2G6 -4368 2559 -2235 826
PLAC8 -1486 3803 4406 1235
PLAU -1912 5281 914 -1527
PLAUR 226 4310 4189 -861
PLCG1 -749 5789 -3949 958
PLCG2 -1458 6158 3982 2803
PLD1 2370 2188 4049 -902
PLD3 -2550 2237 2394 354
PLEKHO2 703 6284 4254 6697
PML 1705 1158 976 4574
PNP 823 2158 3217 3516
POLR1C 2228 2648 -3560 5328
POLR1D 804 3932 385 6780
POLR2E -4070 2983 1998 3712
POLR2F -4130 6520 2177 509
POLR2H -1987 7555 -1495 6297
POLR2K 3699 2452 -1615 3853
POLR3A 386 3837 301 5225
POLR3C 3386 7974 466 3978
POLR3D -2976 180 -3773 1967
POLR3E -4047 6433 -3136 1113
POLR3F 3336 7901 -2866 -1022
POLR3G 587 7022 -3591 6659
POLR3GL 192 230 -854 204
POLR3H -4544 6311 -4490 5544
POLR3K 926 708 710 891
POM121 -4007 5147 -934 4680
POM121C -4243 5643 -2686 2061
POU2F1 3493 5425 2773 3909
PPIA -239 5602 -1924 4554
PPIE 1995 6743 -2167 6025
PPM1B 3124 -194 1490 -144
PPP2CA 2133 7688 1877 2598
PPP2CB 3173 15 2037 2771
PPP2R1B 1368 607 -1191 6169
PPP2R5A 1917 1224 2809 -230
PPP2R5B -1113 7049 4073 -286
PPP2R5C 1533 5894 -3487 7072
PPP2R5D -1009 5720 986 3470
PPP2R5E 792 2414 -2786 1402
PPP3CA -123 1244 -187 5978
PPP3CB 4151 5256 913 4044
PPP3R1 579 5005 124 2945
PRCP 2944 6346 2835 611
PRDX6 -1247 4144 -345 5477
PRKACA -1378 3969 4529 890
PRKACB 559 7713 -4630 1712
PRKCB -3677 4193 2655 4963
PRKCD 301 8167 4500 6358
PRKCE -1194 7105 3475 -1183
PRKCQ -1185 3922 -4577 4207
PRKCSH -4486 5300 2163 4697
PRKDC -1551 8114 -2256 6474
PRR5 -4233 4574 -4217 -347
PRTN3 -4653 8354 -2832 5619
PSAP 506 1283 3823 628
PSEN1 2104 1717 4209 4954
PSMA1 2917 5206 1363 4758
PSMA2 1509 4929 -836 5163
PSMA3 4416 1432 -1823 3586
PSMA5 3047 4175 -2828 3319
PSMA6 3897 6144 1661 6676
PSMA7 -246 5863 3266 6901
PSMB1 -371 2981 -803 5409
PSMB10 -3433 689 -161 6388
PSMB2 835 -501 1803 1518
PSMB3 23 780 3778 4305
PSMB5 -2694 183 3229 269
PSMB6 -3103 5638 3472 5817
PSMB7 -2378 1587 2955 4198
PSMB8 949 1746 2054 5155
PSMB9 -217 3058 -3454 4468
PSMC1 928 2242 2194 1413
PSMC3 -2624 4680 847 736
PSMC4 -1230 1188 537 3431
PSMC5 -1694 2039 -2600 5094
PSMC6 4108 118 1373 2356
PSMD1 2911 5546 2375 56
PSMD11 4009 2032 2637 3521
PSMD12 4511 5250 2167 3681
PSMD13 -998 7807 1482 561
PSMD14 3360 3896 85 6314
PSMD2 -3334 6719 2097 3610
PSMD3 -4637 3063 1629 5579
PSMD4 -1530 1685 3940 5313
PSMD6 1854 3171 3275 2336
PSMD7 3595 864 596 2079
PSMD8 -2435 7747 2069 4665
PSMD9 -3510 -186 3384 3375
PSME1 1353 7210 -2849 1614
PSME2 3304 7208 -1478 778
PSME3 802 6539 2470 5231
PSME4 3349 7885 -461 5908
PSMF1 -1946 2260 416 7179
PSTPIP1 -3181 2316 4195 680
PTEN 2106 3654 2736 4814
PTGES2 -4318 -433 -1375 -901
PTK2 -814 2487 -1377 -475
PTK2B -3952 4106 4499 4528
PTPN1 -1209 -294 3707 699
PTPN11 -256 3762 1122 5061
PTPN12 608 -601 1634 -982
PTPN13 -4440 8337 -2577 6848
PTPN18 -1734 887 4371 3436
PTPN2 2787 3163 4008 181
PTPN22 3623 -461 2125 5980
PTPN23 -1373 3838 2730 5426
PTPN4 -398 1836 -4481 784
PTPN6 -1174 2534 4395 6540
PTPN7 1233 1319 -1494 2323
PTPN9 -858 2987 4448 6094
PTPRC 3660 1759 2823 -936
PTPRJ -2062 6860 3552 7167
PTPRN2 -1502 1639 -965 6583
PYCARD -1515 3142 4319 -1818
PYGB -3390 -229 -1259 141
QPCT 1033 1841 3998 -1472
QSOX1 -2300 6788 4519 5725
RAB10 2203 1022 4224 3067
RAB14 3720 1861 1150 -378
RAB18 4478 1161 1696 2764
RAB24 1932 257 4083 -168
RAB27A 3269 7260 2952 222
RAB37 -1677 7528 -2789 409
RAB3A -4569 3507 482 4347
RAB3D 604 5944 3885 1148
RAB4B -2727 7770 3909 4687
RAB5B -516 1208 1896 1957
RAB5C -2850 2984 3898 797
RAB6A 3034 6426 2839 3323
RAB7A 837 -522 3489 -124
RAC1 3574 7484 4225 5539
RAC2 -3760 6815 1945 4576
RACGAP1 3851 3065 2101 4089
RAE1 2280 705 1931 2634
RAF1 537 4277 3739 6571
RALA 2197 1756 -3637 2302
RANBP2 2136 4418 -1280 5164
RAP1A 4512 2607 2624 6567
RAP1B 2749 6134 2033 5966
RAP2B -283 6562 394 5291
RAPGEF1 -3506 6250 1511 6443
RASGRP1 500 3237 -4511 5886
RASGRP2 -3881 4893 -1986 -413
RASGRP3 2257 966 -2637 760
RBBP6 3635 3405 -1799 2861
RBCK1 20 93 3817 -510
RBSN -2650 7872 -1916 6352
RBX1 1451 6206 1453 5881
RCHY1 2651 4138 -16 6484
REL 599 3 3083 1779
RELA -4376 5729 -1050 4332
RELB -1928 4179 2626 577
RHOA 2796 1879 3280 4033
RHOF -3403 3511 -4235 6476
RHOG -703 3967 4093 3664
RICTOR 2489 4606 -2585 2833
RILP -778 5200 3062 4298
RIPK3 1097 1791 4431 6793
RNASEL 1776 3068 3937 3400
RNASET2 -1180 732 3304 7087
RNF111 2625 5548 609 6047
RNF114 2111 -231 1594 6
RNF115 2391 7670 -785 5803
RNF123 -4320 -659 3883 5284
RNF125 -499 4923 -4473 6174
RNF126 -3727 1447 -2733 5632
RNF135 1671 2669 4476 -1613
RNF138 3007 3835 -3918 7051
RNF14 2201 -570 288 -1370
RNF144B 896 7326 4315 -81
RNF19A 2951 4760 -2298 6512
RNF19B -874 5050 2188 2765
RNF213 901 3688 -1362 7094
RNF216 -3207 1260 -3286 4490
RNF220 -4646 3784 -1572 215
RNF25 1312 7230 171 5176
RNF34 3724 5286 -1181 1414
RNF4 250 1925 -1905 4132
RNF41 -467 2353 4133 4401
RNF6 -1329 2767 -1001 366
RNF7 -414 1274 2999 5839
ROCK1 4037 2208 2623 2732
RORA -1351 7045 -4542 6931
RPLP0 -4068 5078 -4060 4850
RPS27A -3731 2481 -4078 2589
RPS6KA1 -2393 6272 4241 -1857
RPS6KA2 -3185 6436 -715 2117
RPS6KA5 4173 7351 -3252 1991
S100A11 1465 3952 4310 6087
S100P -3641 627 3560 3303
S1PR1 -19 -331 -3578 6789
SAMHD1 3503 7333 3768 6189
SAR1B 4471 7978 1753 3060
SARM1 -3359 8141 -3432 4841
SCAMP1 2598 7802 -3481 2645
SDCBP 3311 7419 3605 3834
SEC13 -1298 7330 2552 6209
SEC23A 2416 6271 707 1833
SEC24A 2469 2022 2595 4761
SEC24B 3316 7026 1710 -13
SEC24C -1756 902 2641 -336
SEC24D 2700 6653 3967 1527
SEC31A 2995 5193 779 2523
SEC61A1 -402 5868 1559 421
SEC61A2 3544 6636 -1344 301
SEC61B -1073 453 1749 6422
SEC61G 4221 2858 -947 1928
SEH1L 3665 6621 -4109 3577
SERPINB1 990 -241 4236 -1477
SERPINB6 -3927 7977 3455 2823
SH2B1 -1908 4860 -1276 1436
SH2B3 -2452 3414 3520 3851
SHC1 47 7294 2954 3205
SIAH1 2118 5750 616 494
SIAH2 2202 1871 438 6695
SIGIRR -3514 8336 -2448 6805
SIKE1 3833 950 -2073 1675
SIPA1 -4632 2967 2579 -1268
SKP1 3454 3180 -2543 2680
SKP2 4229 3426 -225 1707
SLA 4046 366 3680 6984
SLA2 -2415 6510 -4294 4870
SLAMF6 -774 2522 -4185 6834
SLC11A1 -326 1277 4588 4001
SLC15A4 -384 -645 3676 -1575
SLC27A2 3534 3271 -3276 -1409
SLC2A3 -2653 4133 3706 -1209
SLC44A2 -3555 1449 11 4322
SLCO4C1 838 1673 1214 -99
SMAD3 -571 5305 -2989 -363
SMARCA4 -3629 2881 2224 6790
SMURF1 -765 197 1222 6932
SMURF2 1161 4750 -3814 3523
SNAP23 2642 7973 1694 -471
SNAP29 -4308 6060 3209 3148
SNRPA1 1550 6067 -2069 1539
SOCS1 3263 5646 2492 4130
SOCS2 1601 6635 -1294 6477
SOCS3 -4725 693 4095 6490
SOCS5 -415 3620 -1558 466
SOD1 90 6446 -2571 1838
SOD2 177 6323 3199 6132
SOS1 3053 3267 -1345 -1984
SOS2 2591 87 3354 3699
SP100 4417 3022 3388 2285
SPSB1 -3536 6092 981 582
SPTAN1 -4171 369 -4508 -407
SQSTM1 -3391 1301 -1278 658
SRC -1769 -92 -2399 -1474
SRP14 2388 5802 1918 5762
STAT1 3698 949 -4441 4969
STAT2 3596 3473 1612 5931
STAT3 1049 7062 3091 4994
STAT4 1560 3811 -4377 4202
STAT5A -3150 -563 3416 -1543
STAT5B -2600 7765 1731 1495
STAT6 -2092 3383 4260 3854
STBD1 785 6119 -200 -658
STIM1 -4039 -127 3292 7262
STK10 -3634 3470 2725 -688
STK11IP -4178 4530 3990 2122
STOM 312 -756 1358 -1584
STUB1 -4241 3481 -957 2320
STX1A -1885 1038 248 4173
STX3 371 5386 3443 2712
STX4 -1332 4490 3053 1609
STXBP2 -623 7943 4521 -155
SUGT1 3689 6377 -97 5004
SUMO1 3870 4413 1420 3368
SURF4 -2330 5219 1962 3679
SVIP 2044 4128 -3340 1104
SYK 927 3885 3853 431
TAB2 1280 -849 -1462 6399
TALDO1 -497 2943 4000 4421
TANK 4486 5680 3220 6237
TAP1 2220 3661 -2414 3742
TAP2 1723 1437 -465 3057
TAPBP -2695 5738 1575 2910
TAX1BP1 4184 1932 1345 1037
TBC1D10C -4516 3143 -3275 6910
TBK1 4522 6493 2094 599
TCIRG1 -2526 4545 4576 1353
TCP1 2342 2222 -2270 -448
TEC 1638 2871 4185 170
TGFB1 -3576 4335 -268 3769
THEM4 -569 8295 -4563 809
THOP1 -2156 2490 -1444 3555
TICAM1 -372 1210 3650 1060
TIFA 1152 8170 -1422 4847
TIRAP -1492 3362 2573 1661
TLR1 2786 2626 3278 -1111
TLR2 3806 6774 4156 4128
TLR3 605 6769 -4494 2949
TLR5 1902 3910 4264 5699
TLR6 1146 -591 2855 -1199
TLR9 -3285 -405 -837 7201
TMBIM1 -3251 2134 3467 -47
TMC6 -3434 1580 -1994 6748
TMEM179B -176 1544 388 5595
TMEM30A 3654 7686 1750 6658
TMEM63A -691 1367 -3328 2620
TNF 3685 -672 -2015 -526
TNFAIP3 -2738 1870 -572 6103
TNFRSF12A -3458 8175 2338 681
TNFRSF1A -757 1590 4369 -1546
TNFRSF1B -1307 1250 4281 6868
TNFRSF25 -3232 307 -4613 6987
TNFSF13 -1161 5409 4326 -1362
TNFSF13B 3729 1281 2715 -384
TNFSF14 751 2869 1178 7175
TNFSF9 -267 -538 2679 447
TNIP2 -2442 793 2575 287
TOLLIP -3659 1231 2911 664
TOM1 -3899 5174 4227 4279
TP53 -1807 1985 -4011 2709
TPP2 2658 7908 -3636 2610
TPR 1846 5115 -1721 4615
TRAF2 40 5279 -2998 5763
TRAF3 -3088 3505 -2224 7206
TRAF6 878 6544 -562 -71
TRAF7 -4564 3290 4353 4600
TRAIP -193 4069 -3254 2585
TRAPPC1 -1916 3999 3336 5232
TREML2 -2351 162 3247 -1968
TREX1 1500 2324 592 -1434
TRIB3 -565 560 -565 3767
TRIM11 -3856 5392 -247 5178
TRIM14 140 1699 905 1982
TRIM2 -2871 2374 -3794 646
TRIM21 3284 -41 2994 -1671
TRIM22 4119 1099 419 2278
TRIM25 1951 6633 4223 446
TRIM26 -364 4586 2045 3540
TRIM35 -2740 4825 -4337 1556
TRIM36 3687 3012 790 -1285
TRIM37 931 5171 -1982 3725
TRIM38 4208 5505 2662 4882
TRIM39 -2276 6667 -2227 6696
TRIM4 -1089 8222 -3571 7141
TRIM41 -3198 6375 3849 7009
TRIM45 448 5168 -3327 -1040
TRIM46 -221 3178 -3184 3136
TRIM5 4187 5670 1797 395
TRIM56 1413 2971 -1165 5738
TRIM62 -1441 6587 -654 3890
TRIM68 -1855 -333 -3500 -539
TRIM8 -2686 4622 4202 6373
TRIM9 853 2438 2620 3459
TRIP12 801 7691 3067 6253
TRPC1 1888 4746 -3667 -631
TRPM2 -2751 7757 4355 -1792
TSPAN14 -2003 917 4079 4962
TUBB -357 3701 -2272 6246
TUBB4B -2428 6398 2462 7160
TXK -3364 2757 -4527 4859
TXLNA 937 8130 839 7005
TXN 1873 336 3237 -1733
TXNDC5 2037 7500 -1760 -1871
TXNIP 4106 3959 -1903 6152
TYK2 -2482 1902 4365 4072
TYROBP -1849 830 4152 -1995
UBA3 4072 719 3656 4052
UBA5 3394 3494 -1850 911
UBA52 -3208 4386 -596 -69
UBA6 4397 2569 1378 -917
UBA7 -1691 3029 575 -1589
UBAC1 -2684 1747 3877 -157
UBB -2084 561 -996 5058
UBC -1739 2624 1876 3220
UBE2B 4219 3310 7 5146
UBE2C -167 1577 -861 4534
UBE2D1 1930 4687 3454 2741
UBE2D2 -56 4255 -1159 2134
UBE2D3 3202 2444 2392 3005
UBE2D4 3008 -543 -2854 915
UBE2E1 3227 3136 113 2408
UBE2E2 410 6892 -1061 2070
UBE2E3 377 666 279 -777
UBE2F -1448 7563 2817 6895
UBE2G1 1835 3441 589 214
UBE2G2 -3900 6380 -3698 6797
UBE2H -391 3411 1847 1146
UBE2J1 2637 4265 2804 1013
UBE2J2 -2941 8148 2849 6011
UBE2K 3615 7162 1074 3260
UBE2L3 3050 -485 2085 119
UBE2L6 2934 760 -3002 1295
UBE2M -4705 5150 1539 2052
UBE2N 3397 6741 -1303 4833
UBE2O -3863 7207 -1448 6885
UBE2Q1 102 3122 1177 2054
UBE2Q2 2723 853 -4396 -223
UBE2R2 -146 -87 3597 -1207
UBE2S -993 -545 895 -706
UBE2V1 2034 4568 -1420 2792
UBE2V2 3825 5511 -976 3547
UBE2W 3586 7009 1318 5412
UBE2Z -812 2929 -2680 6569
UBE3A 3137 620 -1629 2812
UBE3B -1782 4195 3105 709
UBE3C -835 8320 49 6989
UBE3D 1681 -825 -3012 -1595
UBOX5 -1005 3105 2159 5846
UBR1 1954 2209 -471 460
UBR2 2359 4111 2550 2591
UFL1 3648 4025 -1544 3864
UNC13D -3097 481 4403 -1904
UNC93B1 100 8116 4277 4748
UNKL -1933 528 833 -1601
USP18 4340 -385 -2548 -1012
VAMP2 258 533 -3262 -1237
VAMP3 1811 2454 2982 619
VAMP8 -2659 3376 1656 868
VAPA 2045 3824 3031 4245
VASP -1291 3413 3718 1142
VAT1 -3926 1426 4292 -1357
VAV1 -2612 6923 3874 5832
VAV2 -832 7700 2796 4133
VAV3 -4054 8267 2141 -685
VCL -1153 1830 476 3614
VCP -2285 7849 1665 1908
VEGFA -3059 827 1628 87
VHL -1365 2716 227 5208
VIM -1688 3605 4349 3780
VRK3 1695 5188 2478 2903
VTN -210 2502 1272 -1925
WASF1 -547 758 4502 -830
WASF2 -2160 1232 3929 -134
WASL 2751 7375 -567 4644
WIPF1 -2325 2893 -1463 -784
WIPF2 655 565 2515 -1017
WSB1 4440 4563 4190 4174
WWP1 3419 4683 -4565 479
XAF1 4429 4678 -1243 -1462
XRCC5 1691 3512 -1013 1327
XRCC6 661 2803 -3543 3282
YES1 677 -619 -2471 5197
YPEL5 1717 -147 2447 3986
YWHAB 4207 4074 788 2152
YWHAZ 3562 2726 -278 4293
ZAP70 -4216 1398 -4044 7248
ZBP1 3229 515 -2798 7174
ZBTB16 -4455 6498 1895 -42
ZEB1 325 6286 -3849 5935
ZNRF1 -3998 5267 -930 -819
ZNRF2 -2764 558 -2334 3277





Metabolism of RNA

Metabolism of RNA
metric value
setSize 535
pMANOVA 3.65e-20
p.adjustMANOVA 6.48e-20
s.dist 0.257
s.t0_crp_RNA 0.00411
s.t0_crp_meth -0.0412
s.pod_crp_RNA -0.234
s.pod_crp_meth 0.0964
p.t0_crp_RNA 0.873
p.t0_crp_meth 0.11
p.pod_crp_RNA 7.18e-20
p.pod_crp_meth 0.000176



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA pod_crp_meth
RPS2 -4571 6973
GEMIN4 -4634 6847
TSR1 -4621 6837
NUP88 -4454 7082
RPL3 -4610 6751
RPS3A -4365 7066
NDC1 -4667 6480
RPL7 -4292 7008
CNOT6L -4280 6260
NUP107 -4115 6299
SNU13 -3664 7052
RPL34 -3944 6513
UPF3A -3579 6961
SNRNP40 -3947 6267
RPS5 -4065 6070
RPS12 -3896 6329
RPLP2 -3815 6421
PRPF19 -3975 6015
WDR43 -4139 5508
ALKBH8 -4555 5002

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
AAAS -638 2718 243 1467
ACTB -373 4248 4005 5446
ADAR 2970 5925 1386 3087
ADARB1 -688 6467 -376 -972
ADAT1 -412 2989 -729 5557
ADAT2 3166 6235 -2841 3497
ADAT3 -3388 1349 2580 6332
AKT1 -4471 4213 2297 1109
ALKBH8 1400 2312 -4555 5002
ALYREF -2943 3402 -1458 6735
ANP32A 805 3037 4023 1765
AQR 2807 380 502 -1469
BMS1 -1273 279 -4313 -1753
BUD31 408 4772 2077 2740
BYSL -2328 5900 -2573 6806
C1D 4279 3651 206 2322
C2orf49 4203 4767 -2130 2636
CASC3 -2211 3328 2647 5105
CCAR1 4043 6118 -658 4000
CCNH 4319 5970 2670 1260
CD2BP2 -3008 1794 3407 -544
CD44 498 4392 3154 4897
CDC40 3487 3340 1326 7122
CDC5L 3354 978 503 -742
CDK7 3836 3659 1886 4034
CDKAL1 3223 -182 -2347 4216
CHERP -4093 6140 -1173 2907
CLNS1A 3455 5265 -2574 -278
CLP1 -616 2944 1426 2378
CNOT1 -24 2748 -442 4958
CNOT10 1906 1981 -852 3018
CNOT11 2653 2636 493 3729
CNOT3 -2438 3446 3132 3093
CNOT4 4218 2243 -1242 5999
CNOT6 3521 6031 1641 4652
CNOT6L -926 4317 -4280 6260
CNOT7 4102 6482 -4009 -58
CNOT8 2112 5181 -110 5796
CPSF1 -1060 6585 1861 1083
CPSF2 3577 2290 1770 988
CPSF3 2898 -399 2488 5336
CPSF4 -3531 7169 -943 1770
CRNKL1 2014 8025 -1493 5504
CSNK1D -4441 6564 2787 3046
CSNK1E -3951 7015 -3414 3000
CSTF1 4 6872 -3334 6207
CTNNBL1 -380 6381 1764 2615
CTU1 -4059 3389 1313 4161
CTU2 -3153 7833 -1746 7024
CWC15 3150 6685 211 -1125
CWC22 4404 5009 -1699 4010
CWC27 4385 3882 -379 -818
DCAF13 -562 1410 -1783 862
DCP1A 2646 4253 -3323 5068
DCP1B -1055 5081 -4312 2554
DCP2 3639 -278 1475 5675
DCPS -3749 4073 885 5059
DDX1 3120 1220 -2520 2193
DDX20 2214 5336 -4275 3954
DDX21 2972 7462 -1540 3312
DDX23 -1250 7546 2286 2707
DDX42 331 955 -966 1669
DDX46 2790 4721 321 2158
DDX47 4326 892 -3647 -50
DDX49 -4479 3907 1633 5580
DDX5 -772 1742 -1573 1804
DDX52 4531 3595 579 -204
DDX6 1045 3344 -1725 2014
DHX16 -3517 2815 -566 3127
DHX37 -3145 6236 -2526 4194
DHX9 243 6405 -2418 5545
DIS3 4375 4884 -1622 -754
DNAJC8 3588 904 -863 861
DUS2 -800 5712 2301 710
EBNA1BP2 -556 1401 -3067 6233
EDC3 -3346 4400 696 3531
EDC4 -3747 2267 -1262 -1376
EFTUD2 -1290 8218 3157 2652
EIF4A1 568 5332 2238 881
EIF4A2 3750 5307 -4415 3601
EIF4A3 -2476 5309 -384 4597
EIF4B -2849 3070 -3855 5585
EIF4E 4474 5594 818 6719
EIF4G1 -3029 3207 3785 5764
ELAC2 -936 5459 -1517 275
ELAVL1 323 6880 -2626 1665
ENPP2 1354 7463 1224 3897
ERCC2 -2656 1778 3047 1849
ERCC3 223 3545 2049 1487
ERI1 3766 -203 768 -139
ETF1 3017 7097 1676 151
EXOSC1 2149 7237 992 316
EXOSC10 1827 1777 -2188 802
EXOSC2 -3836 -378 -3761 5343
EXOSC3 851 4957 110 3245
EXOSC4 -2860 5195 3343 64
EXOSC5 -3756 469 -3823 790
EXOSC6 -1352 3467 -3661 1534
EXOSC7 -4443 4094 -2938 -158
EXOSC8 3032 5356 -3616 1364
FAM98B 4390 3565 -2355 2205
FAU -4223 5971 -437 6875
FBL -4678 -91 -4594 -43
FCF1 2808 5725 -1239 6761
FIP1L1 858 2985 -1642 3099
FTSJ3 -2540 4963 1385 4235
FUS -1127 1056 -114 5261
FYTTD1 2371 4178 -3394 5126
GAR1 -224 3758 -2986 879
GCFC2 3865 -584 -4195 -1739
GEMIN2 3762 -768 -338 -290
GEMIN4 -2701 6849 -4634 6847
GEMIN5 -1157 -107 -3290 1695
GEMIN6 1303 413 -1162 -1085
GEMIN7 -1960 357 1850 -388
GLE1 -902 5878 2109 1687
GNL3 2241 1853 -4428 1201
GSPT1 2757 4351 -2932 -1153
GTF2F1 -4236 1342 2079 558
GTF2F2 2000 4258 2006 5306
GTF2H3 1068 8239 -3652 5703
GTF2H4 -995 6151 892 5239
GTF2H5 1838 1881 -279 3417
GTPBP3 -3480 5098 -1878 1640
HBS1L 2688 488 -1585 598
HEATR1 566 6362 -3326 5200
HNRNPA0 -4722 567 -4225 3059
HNRNPA2B1 1271 2586 2367 2721
HNRNPC 1732 735 1301 213
HNRNPD -3228 2603 -1020 -667
HNRNPF -3188 3524 -532 5855
HNRNPH1 1863 2157 -1951 2373
HNRNPK 707 5598 1024 3141
HNRNPL -4107 3364 2180 6117
HNRNPM -1989 6919 1257 2773
HNRNPR 318 4894 -3603 4902
HNRNPU -1010 5652 -328 4166
HNRNPUL1 -4608 3099 -386 2869
HSPA1A -3490 1106 2517 -920
HSPB1 -1006 2000 -832 883
IGF2BP3 995 3852 979 -734
IMP3 -1621 6086 -3137 5540
IMP4 -2501 4256 -3803 3786
ISG20L2 530 2755 -15 6436
ISY1 -3327 2040 -615 1885
KHSRP -2305 835 218 1774
KRR1 2893 -801 -2865 -1950
LCMT2 -1284 4334 -3407 6262
LSM1 662 2876 450 5932
LSM10 -587 4321 2838 1062
LSM11 -3574 2770 -4485 -211
LSM2 -1262 6168 -975 5946
LSM3 2146 2589 6 2560
LSM4 -2717 3989 -2478 -239
LSM5 2291 5599 -3717 4273
LSM6 -1990 6676 2048 2778
LSM7 -4507 5117 -2390 689
LSM8 1677 3014 -2031 -1734
LTV1 2852 2898 -1941 2915
MAPK14 1563 2227 4024 2465
MAPKAPK2 -3939 1416 2421 3265
METTL1 -674 6979 -4164 4405
METTL14 4473 6571 -1356 -834
MNAT1 2008 2598 -2465 1516
MPHOSPH10 4488 5449 -2942 5400
MPHOSPH6 1961 6222 -949 5533
MRM1 -2461 2109 -3228 -159
MTERF4 -2411 5813 -4491 3503
MTO1 3388 1501 -2461 396
NCBP1 4110 6523 -472 5857
NCBP2 4266 3714 -3787 4776
NCL -1980 6791 -4315 5053
NDC1 -28 -272 -4667 6480
NHP2 -3191 6971 -2519 4826
NIP7 1970 5730 -3733 4218
NOB1 -2719 -262 -4364 2003
NOC4L -1413 5509 2788 -799
NOL11 3694 -390 -4414 2571
NOL12 -297 5999 2186 -1549
NOL6 -4372 6081 -3107 4556
NOL9 1673 -787 -3236 -1444
NOP10 -1724 2394 4174 2081
NOP14 -2035 -731 -4619 2209
NOP2 -3532 5036 -2782 6401
NOP56 -390 117 -3865 996
NOP58 3566 2112 -4420 1333
NSUN2 3540 -108 1947 2230
NSUN4 1766 777 1615 3316
NSUN6 3919 4433 887 2767
NUDT21 2631 5030 -4023 4270
NUP107 2943 1017 -4115 6299
NUP133 2030 1473 -2474 935
NUP153 1372 7264 -1870 4343
NUP155 1163 5083 -3460 3043
NUP160 1232 5781 -4066 1293
NUP188 -2474 591 -3287 2922
NUP205 1308 370 -3162 1670
NUP210 -4099 775 -1841 690
NUP214 779 7322 3866 4368
NUP35 3287 7567 -4566 -557
NUP37 1488 500 -594 3398
NUP43 3972 139 -3557 6344
NUP50 2599 5772 -517 6704
NUP54 4432 6517 -2306 831
NUP62 -1277 2703 156 4608
NUP85 2428 5395 -713 4517
NUP88 1692 6430 -4454 7082
NUP93 1140 7850 -1307 2006
NUP98 808 1649 64 -747
NXF1 116 1942 2995 1236
NXT1 -4177 660 -3979 4712
PABPC1 1721 3723 -1442 3011
PABPN1 -2016 7253 994 3061
PAIP1 2851 -396 -2429 6165
PAN2 612 2144 704 -743
PAN3 3983 -799 473 1365
PAPOLA 3033 3883 812 4316
PARN 1656 5124 -1817 5478
PATL1 3730 6832 3899 -473
PCBP1 -3489 1810 1951 865
PCBP2 -2726 1016 -881 3201
PDCD11 -2808 1973 -3660 3455
PDCD7 -1044 7505 -2726 3569
PELP1 -637 6658 -3306 2742
PES1 -4103 222 -2386 3288
PHAX 1907 2467 -4010 5543
PLRG1 4225 5663 -3030 5210
PNO1 2611 1456 -3399 6494
PNRC2 4481 3773 -2191 5676
POLDIP3 -1158 1386 3841 3182
POLR2A -2661 -175 2387 4046
POLR2B 2791 1490 -2187 5561
POLR2C -1223 4488 -1052 6354
POLR2D 1826 1345 -3754 -614
POLR2E -4070 2983 1998 3712
POLR2F -4130 6520 2177 509
POLR2G -3529 8023 2161 1604
POLR2H -1987 7555 -1495 6297
POLR2I -4150 6339 -662 5655
POLR2K 3699 2452 -1615 3853
POM121 -4007 5147 -934 4680
POM121C -4243 5643 -2686 2061
POP1 -1496 5074 -1937 3613
POP4 740 397 -194 1072
POP5 -1211 1292 -2208 5987
POP7 -2981 3488 376 3070
PPIE 1995 6743 -2167 6025
PPIH -1482 3640 -3512 2129
PPIL1 1884 -329 -3217 -1624
PPIL3 2468 6728 -1039 375
PPIL4 4373 5682 -1571 -164
PPIL6 564 1721 1174 147
PPP2CA 2133 7688 1877 2598
PPP2R2A 4508 542 -554 -752
PPWD1 4053 5829 -2387 -1683
PRCC -3932 3938 1652 2255
PRKCA -2583 7972 -2473 6892
PRKCD 301 8167 4500 6358
PRMT5 735 1328 678 2005
PRPF19 -4460 6581 -3975 6015
PRPF3 2501 5430 -558 1089
PRPF31 -4209 1107 -874 3855
PRPF38A 3351 3209 -1378 5305
PRPF40A 4315 -724 -171 5626
PRPF6 -1594 5822 -3191 4284
PRPF8 -3675 2300 -2834 516
PSMA1 2917 5206 1363 4758
PSMA2 1509 4929 -836 5163
PSMA3 4416 1432 -1823 3586
PSMA5 3047 4175 -2828 3319
PSMA6 3897 6144 1661 6676
PSMA7 -246 5863 3266 6901
PSMB1 -371 2981 -803 5409
PSMB10 -3433 689 -161 6388
PSMB2 835 -501 1803 1518
PSMB3 23 780 3778 4305
PSMB5 -2694 183 3229 269
PSMB6 -3103 5638 3472 5817
PSMB7 -2378 1587 2955 4198
PSMB8 949 1746 2054 5155
PSMB9 -217 3058 -3454 4468
PSMC1 928 2242 2194 1413
PSMC3 -2624 4680 847 736
PSMC4 -1230 1188 537 3431
PSMC5 -1694 2039 -2600 5094
PSMC6 4108 118 1373 2356
PSMD1 2911 5546 2375 56
PSMD11 4009 2032 2637 3521
PSMD12 4511 5250 2167 3681
PSMD13 -998 7807 1482 561
PSMD14 3360 3896 85 6314
PSMD2 -3334 6719 2097 3610
PSMD3 -4637 3063 1629 5579
PSMD4 -1530 1685 3940 5313
PSMD6 1854 3171 3275 2336
PSMD7 3595 864 596 2079
PSMD8 -2435 7747 2069 4665
PSMD9 -3510 -186 3384 3375
PSME1 1353 7210 -2849 1614
PSME2 3304 7208 -1478 778
PSME3 802 6539 2470 5231
PSME4 3349 7885 -461 5908
PSMF1 -1946 2260 416 7179
PTBP1 -4071 1931 -1813 815
PUF60 -4603 1818 -537 2049
PUS1 -4472 3146 -2205 4829
PUS3 4012 -785 137 965
PUS7 1768 1476 -4163 5386
PWP2 -3288 3400 -3239 5075
QTRT1 -3112 5428 -3348 5787
RAE1 2280 705 1931 2634
RAN 1899 2279 -3437 1483
RANBP2 2136 4418 -1280 5164
RBM17 -139 125 -2810 2268
RBM28 -2460 5591 -2557 3412
RCL1 -2020 7155 -3537 6341
RIOK1 2656 7804 -1376 6496
RIOK2 3564 1632 -3897 1638
RIOK3 3495 2135 1073 3472
RNGTT 2340 1731 365 14
RNMT 3322 2739 -2660 6869
RNPC3 3106 5899 -644 3737
RNPS1 -2473 2186 -3151 537
RPL10A -2021 3601 -3665 3590
RPL11 -2195 4759 -3631 -495
RPL13 -2399 2561 -2415 6187
RPL13A -2217 1446 -4059 5521
RPL14 -2732 1645 -4433 -798
RPL15 -2979 2857 -3337 1424
RPL17 -3043 1594 -3926 2296
RPL18 -3380 7714 -3552 4478
RPL18A -3938 751 -3444 4254
RPL22 -2825 5674 -4182 1020
RPL23 -1858 5701 -3100 2729
RPL23A 48 7818 -4430 4559
RPL26 -2272 4855 -3465 6407
RPL26L1 -972 2107 2314 3971
RPL27A -4061 5311 -3904 1697
RPL28 -2225 2129 -798 4754
RPL29 -3990 4921 -3643 2875
RPL3 -4508 360 -4610 6751
RPL31 -3651 495 -3411 -34
RPL32 -3564 4776 -3623 5998
RPL34 -904 906 -3944 6513
RPL35 -3999 2909 -3508 4823
RPL36 -4523 -158 -2815 2877
RPL36AL -4195 7236 -1732 6350
RPL37 -4723 3433 -2971 5392
RPL37A -3969 1847 -2033 4981
RPL38 -4417 4342 -2941 4430
RPL39L -2468 4218 -28 5079
RPL4 -2456 997 -4254 1394
RPL41 -3631 4792 -2682 821
RPL6 466 3352 -3950 1979
RPL7 -2841 5004 -4292 7008
RPL8 -4442 7620 -2781 5093
RPL9 -990 4307 -3377 844
RPLP0 -4068 5078 -4060 4850
RPLP1 -4307 4259 -1607 1521
RPLP2 -4667 3685 -3815 6421
RPP14 3290 6084 -993 2236
RPP21 -3292 6702 -86 2599
RPP25 -2510 7139 -3453 5743
RPP30 3476 4936 -3223 668
RPP38 3369 1308 -2914 4779
RPP40 1457 2935 -4562 570
RPPH1 2032 1749 4352 5011
RPS10 -4168 2356 -3457 3925
RPS11 -3884 1199 -3013 4224
RPS12 -4261 7672 -3896 6329
RPS15 -3350 1899 -2308 5621
RPS15A -3437 1657 -3621 6110
RPS16 -4379 4270 -3448 5979
RPS18 -4218 4809 -3284 4162
RPS19 -3954 1402 -2451 -362
RPS2 -4698 -704 -4571 6973
RPS20 -1234 4742 -3936 3461
RPS23 -3376 -353 -3858 2986
RPS24 -35 6157 -2288 -518
RPS25 -2395 138 -4129 1797
RPS26 -1529 6099 -2398 5515
RPS27A -3731 2481 -4078 2589
RPS27L 3563 2925 1087 1405
RPS28 -4025 17 -2863 -1178
RPS29 -4598 3919 -3034 5600
RPS3 -3753 4053 -4143 4598
RPS3A 1196 4024 -4365 7066
RPS5 -4113 3314 -4065 6070
RPS6 -3204 4732 -4317 361
RPS7 -2809 3926 -3695 4407
RPS8 -1253 -347 -3213 -79
RPS9 -3353 1940 922 627
RPSA 1973 687 -1923 2072
RRP1 -894 4246 340 5199
RRP7A -281 3244 -1932 1582
RRP9 -4587 -253 -3731 653
RTCB 1219 416 331 -1471
SART1 -3402 482 1700 5775
SEC13 -1298 7330 2552 6209
SEH1L 3665 6621 -4109 3577
SENP3 -1093 8054 1649 5393
SET 352 2248 -3641 -1665
SF1 -2539 3369 -467 2873
SF3A1 -2918 8134 -2591 6185
SF3A2 -4312 -383 -2184 7182
SF3A3 -2055 4848 -3066 4520
SF3B2 -847 2397 1002 2483
SF3B3 -598 1890 -4108 423
SF3B4 -216 3549 1564 1093
SF3B5 -3549 6439 258 2879
SKIV2L -2073 5609 2066 6257
SLBP 2900 6823 -2054 428
SLU7 4019 1803 -717 1094
SMG1 55 8307 -687 4788
SMG5 -2955 -215 -767 5172
SMG6 -2359 -678 -1874 6205
SMG7 1612 3107 3551 2361
SMG8 2347 7988 255 1691
SMNDC1 3918 7085 734 3512
SNRNP200 -3395 4541 -2684 1391
SNRNP25 -2875 1878 257 2891
SNRNP27 3367 3603 -503 1452
SNRNP35 2600 3064 3019 -1466
SNRNP40 2940 3644 -3947 6267
SNRNP48 4525 -392 -2439 -1044
SNRNP70 -3105 5169 -2380 2532
SNRPA 518 677 1350 1269
SNRPA1 1550 6067 -2069 1539
SNRPB -2032 7594 -1468 4947
SNRPB2 3877 5793 -991 1876
SNRPC -675 1741 -266 3152
SNRPD1 3006 922 -1546 4844
SNRPD2 -4245 412 -2029 -551
SNRPD3 795 6797 -1853 -377
SNRPE 175 5854 -3125 3730
SNRPG 3070 6466 1508 3411
SNRPN 778 -761 -4134 -1422
SNU13 -1800 -638 -3664 7052
SNUPN 2165 944 1885 2739
SNW1 3539 3975 580 2517
SRRM1 4398 6138 -860 3813
SRRM2 -1817 -706 1249 -214
SRRT -1902 844 -1354 1308
SRSF10 2268 6868 -3534 2085
SRSF11 2689 7829 -3580 -51
SRSF2 464 3247 -2180 212
SRSF3 3264 185 -2400 -1223
SRSF4 383 -515 2645 6865
SRSF7 2068 4748 -1973 618
SRSF9 -643 8057 3465 745
SUPT5H -3482 5357 -1088 2020
SYF2 2727 7292 366 4211
SYMPK 70 3596 1744 2886
TBL3 -3751 5261 19 5417
TEX10 3497 -297 -4086 1204
TFB1M 2498 2147 -1945 1831
TFIP11 -272 979 1457 936
THADA 2308 5765 -2192 4243
THG1L 646 1004 -2804 2917
THOC1 3589 7129 -2135 6021
THOC5 955 4206 3843 3364
THOC7 4273 3728 538 5592
THUMPD1 3126 1431 -4395 -871
TNFSF13 -1161 5409 4326 -1362
TNKS1BP1 -3500 1203 -3259 3401
TNPO1 1745 4371 -1447 4634
TP53RK -53 6071 -4127 2847
TPR 1846 5115 -1721 4615
TPRKB 3066 6491 -3202 3473
TRDMT1 2332 1428 1364 -401
TRIT1 2084 1364 -706 6753
TRMT1 -2480 1484 -1428 -744
TRMT10A 3258 -520 2701 1313
TRMT11 4252 5292 -4277 2032
TRMT112 -4008 7769 -160 1929
TRMT12 -1483 -493 -404 -1651
TRMT44 -1611 -652 -1212 -1514
TRMT6 2833 8190 2076 3940
TRMT61A -4648 4946 -3147 3423
TRMT61B 135 4498 -3497 5387
TRMU 3 6858 -931 6385
TRNT1 4380 1236 -1054 4674
TSEN15 3597 1028 -3168 502
TSEN2 409 5795 -3165 3306
TSEN34 -3161 7397 2828 1820
TSEN54 -2123 1399 -3716 591
TSR1 -341 6406 -4621 6837
TSR3 -4199 1625 -151 6368
TTC37 1359 -69 -3103 334
TXNL4A -3023 -315 2464 2176
TYW1 85 3702 -4257 2393
TYW3 2638 3986 -3574 985
TYW5 3041 7677 238 3607
U2AF1 -276 6502 1471 1030
U2AF1L4 -1709 -451 387 5614
U2AF2 -4347 6388 346 6130
U2SURP 4202 7945 -1911 6590
UBA52 -3208 4386 -596 -69
UBB -2084 561 -996 5058
UBC -1739 2624 1876 3220
UPF1 -2902 707 2612 5956
UPF2 3948 4005 -99 3840
UPF3A -1847 6389 -3579 6961
URM1 -4463 2771 354 3783
USP39 -1523 3707 236 5624
UTP15 4103 2192 -3831 5062
UTP18 1555 4515 1472 3357
UTP20 2389 4984 -3079 5084
UTP3 -823 5891 -608 3926
UTP6 3752 1891 -2359 3932
WBP11 -105 1393 -4057 986
WBP4 4410 7066 906 1882
WDR12 2088 2282 -541 6792
WDR18 -2689 2119 -1828 -1077
WDR3 -11 550 -3655 -1385
WDR33 2305 7055 -106 3468
WDR36 2325 4898 -2570 6599
WDR43 1173 2125 -4139 5508
WDR61 1345 2434 -528 1522
WDR75 2774 3709 -4340 4613
WDR77 1111 -644 -3122 2831
WTAP 3512 5997 -217 3489
XAB2 -3401 44 -244 1760
XPO1 4384 5608 -1759 6845
XPOT 2657 -75 -2853 2981
XRN1 2444 -176 -1395 -1959
XRN2 1078 2908 3514 -29
YBX1 -2060 4522 -183 6423
YWHAB 4207 4074 788 2152
YWHAZ 3562 2726 -278 4293
ZBTB8OS 2630 4877 3387 266
ZCRB1 3551 2597 -638 438
ZFP36 -4681 -334 -7 5099
ZFP36L1 807 873 2458 5470
ZMAT5 -1981 1503 3944 6882





Signal Transduction

Signal Transduction
metric value
setSize 1289
pMANOVA 2.88e-12
p.adjustMANOVA 4.61e-12
s.dist 0.131
s.t0_crp_RNA -0.0362
s.t0_crp_meth 0.0141
s.pod_crp_RNA 0.114
s.pod_crp_meth 0.0523
p.t0_crp_RNA 0.0369
p.t0_crp_meth 0.415
p.pod_crp_RNA 5.43e-11
p.pod_crp_meth 0.00253



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA pod_crp_meth
KSR1 4333 7144
ATP6V0D1 4411 6934
CTSD 4479 6620
MYO9B 4362 6775
PTPN6 4395 6540
PRKCD 4500 6358
FURIN 3951 7178
GNG5 4182 6510
GIT2 4323 6160
GMIP 4537 5867
SOCS3 4095 6490
GRB2 4230 6239
ARHGAP9 4113 6255
MAPK1 4197 6097
CLTC 3511 7256
PTPRJ 3552 7167
AGO1 3460 7137
RAF1 3739 6571
RHOT1 4404 5574
RALB 3581 6831

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
AAAS -638 2718 243 1467
AAMP -4607 1163 -1372 7118
AATF -1535 4239 2483 5312
ABCA1 -336 7231 2025 -82
ABCD3 1342 6455 888 5773
ABCG1 -2592 1311 -3943 6769
ABHD12 -4206 7116 -1418 5948
ABHD17A -4658 -853 -2785 -550
ABHD17B 130 -623 -2977 -676
ABHD6 1803 6924 1640 2533
ABI1 4121 520 2868 3253
ABI2 570 1453 -3567 -206
ABL1 -3241 5957 1585 2469
ABL2 -280 4972 -684 5307
ABR -2028 4154 4503 4698
ACBD5 1401 6073 837 2753
ACTA2 -3252 -617 753 4717
ACTB -373 4248 4005 5446
ACTG1 -3456 6407 3191 1603
ACTN1 -3263 -14 2475 7237
ACTR2 3144 4932 2747 3844
ACTR3 2753 4481 2482 5950
ACVR1B -178 7477 4511 -23
ACVR2A 2067 7246 -4198 6955
ADAM10 2914 3590 3423 2760
ADAM17 3217 4696 4464 4154
ADAP1 -3123 5370 4077 -1539
ADCY4 1603 6214 3332 -1005
ADCY7 -3423 2390 2998 -981
ADCY9 -4694 8388 -1386 5438
ADD3 1912 385 -1566 4726
ADGRE5 -2627 2052 3671 -1468
ADM -994 7605 4548 5104
ADORA2A -997 8333 -974 7183
ADORA3 1292 1221 2616 -1895
ADRB2 -1851 5254 -3071 2808
AGO1 -3758 -794 3460 7137
AGO2 -2786 553 1558 7193
AGO3 4341 8301 1027 3465
AHCTF1 913 4232 -2207 -864
AHCYL1 1297 6888 1605 2692
AKAP13 -1862 4566 2487 4321
AKT1 -4471 4213 2297 1109
AKT1S1 -4589 5777 3404 1894
AKT2 -4622 3462 2041 5430
ALDH3A2 545 7647 54 5653
AMIGO2 3013 -550 -3744 -696
ANKFY1 953 6978 2210 6511
ANKLE2 -228 1681 1312 3585
ANKRD26 3465 1090 -1577 3643
ANLN 2842 5382 -1006 410
AP2A1 -2927 1888 4575 -316
AP2M1 -4018 5714 2737 3723
AP2S1 -1597 3981 3589 6037
APBB1IP 2235 5817 3712 3821
APC 663 6233 688 1992
APH1A -3566 1656 857 -119
APH1B 3237 2583 3451 6783
APP -1029 7569 1303 6621
ARAP1 -2427 3846 4373 1485
ARAP2 1177 1826 -1919 5750
ARF6 -1265 6257 -355 3741
ARFGAP3 3528 7016 1360 724
ARHGAP1 -1116 1933 4141 -524
ARHGAP10 1606 7018 -2695 6499
ARHGAP11A 2445 2305 320 109
ARHGAP11B 3561 181 2408 3318
ARHGAP12 3483 -420 -1285 1249
ARHGAP15 1850 6916 -3250 4590
ARHGAP17 2310 6742 -919 6870
ARHGAP18 1317 6802 2797 2306
ARHGAP19 247 1920 3316 5726
ARHGAP21 -1728 7771 278 6458
ARHGAP23 -1004 136 2961 6786
ARHGAP25 665 -184 -235 -568
ARHGAP26 1003 3599 4289 -247
ARHGAP27 -2038 -365 4474 -1906
ARHGAP30 -2454 5293 2923 2549
ARHGAP35 -3296 6411 -2214 2758
ARHGAP39 -711 8384 -176 6947
ARHGAP5 1693 4550 -4615 6628
ARHGAP9 -2519 389 4113 6255
ARHGDIA -4384 -252 2815 6668
ARHGDIB -776 -85 3634 1149
ARHGEF1 -1904 5723 566 4486
ARHGEF12 -2531 8125 -1044 5962
ARHGEF17 1360 3696 2793 1438
ARHGEF19 -4693 368 -3506 -87
ARHGEF2 -2563 241 3337 1182
ARHGEF26 3520 5500 371 6997
ARHGEF3 -943 1627 -4251 3996
ARHGEF39 -1957 1346 -843 -1562
ARHGEF7 -4633 957 532 330
ARL13B 4374 3638 -1914 950
ARL2 -4064 2577 -131 244
ARL4C -3497 -218 -4402 2467
ARPC1B -3236 2831 4244 1709
ARPC2 1775 5683 3457 2292
ARPC3 2785 4820 3580 3208
ARPC5 2109 2335 3836 2611
ARRB1 -3738 3174 2221 -1276
ARRB2 -2258 4618 4280 2913
ASH2L 2764 5752 2617 3075
ATF1 4365 685 1579 2989
ATN1 -2201 1347 168 3096
ATP2A1 -938 6531 3218 5722
ATP2A2 -1033 3457 3675 -1548
ATP2A3 -3896 -65 -1072 1877
ATP6V0A1 -73 5522 4481 -1569
ATP6V0A2 1039 5229 -2100 6651
ATP6V0B -2906 4920 4040 5502
ATP6V0C -819 2497 4204 2933
ATP6V0D1 -717 5801 4411 6934
ATP6V0E1 -98 5534 3098 1836
ATP6V0E2 688 -8 -3868 -1325
ATP6V1A 2260 3916 3165 -1495
ATP6V1B2 1335 2965 3679 -1553
ATP6V1C1 3195 3435 3307 6757
ATP6V1D 3158 446 3682 1096
ATP6V1E1 3127 6210 2844 4775
ATP6V1F -2969 2955 1967 -699
ATP6V1G2 -783 7744 -3696 3740
ATP6V1H 2094 5695 1932 2559
AURKB -572 6976 300 5273
AXIN1 -4500 6775 -2630 -858
AXIN2 526 1695 -4095 152
B4GALT1 -2606 7929 1953 7041
B9D2 -3540 1368 3290 1211
BAD -4109 6579 2513 4373
BAG4 2132 2187 3117 828
BAIAP2 -3214 6287 -510 2757
BAMBI 4024 1383 4148 3576
BAX -2161 -40 3408 1161
BCL2 891 55 -3102 7020
BCL2L1 168 5903 -129 5968
BCL2L11 72 5304 2972 5662
BCL9 -3129 4450 -2893 4908
BCR -3003 5448 -1065 -1911
BIRC2 4449 4494 -741 6624
BIRC3 3504 588 -4618 4816
BIRC5 2315 6240 -142 1965
BMI1 2216 4611 -4071 -805
BMPR1A 2412 303 -2632 5827
BMPR2 184 -67 2801 6820
BRAF 968 80 165 -1524
BRAP 3645 8062 1052 -135
BRK1 -4091 8027 -825 3071
BTRC -2069 66 -3130 -923
BUB1 2426 2179 -2532 67
BUB1B 285 1291 -2551 1523
BUB3 2840 3847 -4479 1717
C1QBP -3114 2067 -4017 5785
C3AR1 4000 1722 4547 -1594
CAB39 2427 -206 2233 7106
CAB39L -3 8158 216 6418
CALM1 1287 3980 -2201 4501
CAMK2D -1499 3793 -4469 -529
CAMK2G 943 31 471 6716
CAMK4 -2175 2725 -4662 2759
CAMKK1 -1745 4986 4257 5612
CAMKK2 -137 7788 4235 1010
CAPZB -747 3052 3210 -308
CASP10 2029 1610 1690 -1805
CASP3 4360 3118 1576 5689
CASP8 2071 5784 -2229 5447
CASP9 110 698 4367 3202
CAV1 244 7711 -1532 4591
CBFB 2554 1466 -1295 5860
CBL -1090 7589 3285 1012
CBX4 -4353 5597 1835 278
CBX6 -4118 7513 1317 3612
CBX8 -1680 73 957 4610
CBY1 2284 4653 -4073 3274
CCDC115 -1096 1939 -1079 3962
CCDC88A 4249 5486 3970 2063
CCDC88C -2774 292 -2450 6959
CCNC 4378 2184 -3183 4187
CCND1 -2434 3555 -1529 1006
CCND3 -3773 2902 3568 4155
CCNE1 2776 6732 -1140 5954
CCNK 1908 2111 1995 6591
CCNT1 -1408 208 -2477 1761
CCR1 2329 4664 3112 -1919
CCR10 -2308 4028 -3331 2454
CCR7 -705 -426 -4357 7124
CCT2 1454 3443 -4591 194
CCT6A -1252 3607 -3940 4842
CCT7 -2248 6757 -2770 6028
CD55 1738 3285 4145 1455
CDC14A -127 7675 -4685 3991
CDC14B 134 1122 -4052 1870
CDC20 -670 5825 -791 2639
CDC42 3320 7040 2741 856
CDC42EP3 2869 5328 3242 1427
CDC42EP4 -1124 4469 4282 1301
CDC42SE2 1587 2945 -4653 6134
CDC73 3220 2286 623 5717
CDCA8 1456 4560 -1078 20
CDK1 3365 4275 -2423 1888
CDK2 872 6555 -1520 2965
CDK4 -2472 6677 -3970 4918
CDK5 -142 4633 4463 3491
CDK5R1 -2189 7694 -1862 7121
CDK8 2364 2319 1443 5793
CDK9 -4663 6640 1582 3144
CDKN1A 1249 7552 1225 2427
CDKN1B -532 1651 -3401 3367
CDON -151 -266 -1867 1466
CENPA 1203 4717 -1074 72
CENPE 4361 2608 751 -74
CENPF 1709 3947 -871 -400
CENPH 1662 4625 -4351 84
CENPK 3605 2014 -1964 1612
CENPL 982 1944 -2352 4693
CENPM 222 5287 -3840 6492
CENPN 1409 811 -1848 1070
CENPO -4594 1162 2213 4160
CENPP -1521 4856 1189 2080
CENPQ 3004 2976 -3493 3793
CENPT -1964 6464 -2530 4797
CENPU 2913 7202 -1114 433
CEP97 1320 4964 1254 -1463
CFL1 -3249 4059 3672 1646
CFLAR 1240 658 4102 3140
CHD1 3695 -661 -607 1273
CHD3 -3994 1460 -3143 6048
CHD4 -1845 1886 -1491 640
CHD8 -2121 3604 1533 -916
CHEK1 2868 3127 -2668 51
CHN1 1879 7176 -4548 5360
CHUK 2695 2702 2681 1111
CIT 1183 2787 723 5652
CKAP4 -813 8287 3854 -987
CKAP5 1096 2719 -346 3384
CKB -3821 6912 1205 4734
CLASP1 -3321 3273 513 2114
CLASP2 221 2879 -2004 -77
CLIP1 3016 5542 4110 921
CLIP3 962 5823 -3049 7130
CLTA 185 1469 2876 -546
CLTB -3946 595 3085 -918
CLTC 461 2670 3511 7256
CNOT6L -926 4317 -4280 6260
CNR2 -296 2753 -3211 -1985
COL9A2 1701 1714 427 4443
COPS2 4242 -444 -219 6454
COPS4 1765 3598 -1111 5824
CPD -503 2484 3795 -1838
CPNE8 3516 8248 2684 4670
CPT1A 1125 24 2235 -1596
CREB1 2387 5046 -1542 1422
CREBBP -4011 6807 2122 892
CRK 3068 5936 3523 6596
CRKL -1398 7466 -102 5166
CSK -2994 1998 3950 4889
CSNK1A1 2368 2045 1805 4451
CSNK1E -3951 7015 -3414 3000
CSNK1G2 -4686 6801 1934 2563
CSNK2A2 769 3941 1687 5734
CSNK2B 63 7476 2450 4742
CTBP1 -4462 8288 924 6469
CTNNB1 2009 6708 3025 5069
CTNNBIP1 -4237 4883 1477 1589
CTNND1 4227 2980 1662 -1707
CTSD -3067 8404 4479 6620
CUL1 4355 1572 -4161 -1190
CUL3 1497 3752 642 -873
CUL5 4190 5397 -1036 344
CXCL2 -4220 7587 1113 -1988
CXCR4 -69 6662 -926 -1433
CXXC5 -4032 8095 -3545 1039
CYBA -2911 5359 4087 2019
CYFIP1 644 8297 4331 256
CYFIP2 -1585 4227 -2032 6157
CYLD 1079 5350 -4487 5704
DAAM1 -1715 7696 -1220 6125
DACT1 3272 1897 677 6078
DAGLB 515 6040 4396 -302
DBN1 -3173 439 39 6170
DBT 4395 1168 -1719 3500
DDRGK1 -4352 5923 2883 6491
DDX5 -772 1742 -1573 1804
DEF6 -4367 1223 -2393 742
DEPDC1B 1791 2406 -380 2392
DERL2 3866 2196 -101 -1576
DGKA 879 30 -3554 7031
DGKD -4664 1873 1631 4805
DGKE 1054 3611 -3235 6505
DGKG 390 -684 3223 4392
DGKH 2981 4503 -1275 4127
DGKQ -2527 358 -1145 3114
DGKZ -4624 3190 -1348 -1313
DHRS3 -4324 2023 -4381 1303
DHRS4 -4529 0 -335 635
DIAPH1 -659 5118 910 2371
DISP2 220 5170 -2845 5405
DLAT -149 1047 -1475 3896
DLD 3259 4509 2627 3542
DLG1 3175 5129 -2957 358
DLG2 -2345 473 1405 -40
DLG4 -1306 281 4191 2607
DLGAP5 2126 3697 -688 -1158
DNAJB1 -4590 5231 -3677 6093
DNAL4 -4067 5461 -269 2609
DNM1 2874 2154 2211 1607
DNM2 -4239 6583 3699 3063
DNMBP 2404 797 3541 -1641
DOCK10 354 3546 -2501 -1156
DOCK4 2505 2302 4309 4094
DOCK7 2335 7606 -1154 2327
DOCK8 573 69 3033 900
DOCK9 -1922 4895 -4584 5505
DRAP1 -725 610 1449 5792
DSN1 2407 2698 -1398 -996
DST 2288 8298 -2555 1704
DTX4 -4129 5372 3400 5143
DUSP1 -4458 3631 1906 2023
DUSP10 1437 1242 395 4699
DUSP16 -3244 -242 -4091 28
DUSP2 -4115 1304 -3121 7007
DUSP3 -328 6561 3398 2260
DUSP4 1176 3581 -1089 2494
DUSP5 2670 5105 1530 6278
DUSP6 -534 7727 -1313 -1941
DUSP7 -2585 6442 -1315 722
DVL1 -4730 5339 -1729 6366
DVL2 -4238 641 -2088 4883
DVL3 -4263 8284 3960 161
DYNC1H1 -2872 1165 -441 4433
DYNC1I2 3141 258 2171 693
DYNC1LI1 3353 6061 2935 3242
DYNC1LI2 1369 3124 3014 -185
DYNC2H1 -2249 5121 -2455 5990
DYNLL1 -405 5371 1250 5150
DYNLL2 -3503 3295 -3679 -924
E2F1 1142 1123 -46 3145
E2F3 2847 5614 2512 2135
E2F4 -2545 833 2056 1015
E2F5 1122 2517 -2283 4180
EBAG9 2755 6367 -3199 4460
ECE1 -2988 586 3586 6247
ECT2 3926 1083 928 -1205
EED 3842 2920 -2433 3088
EEF2K 2775 3220 -2507 4092
EEPD1 -4270 5344 -58 3578
EFCAB7 3213 7840 -3081 -250
EFHD2 -3786 5818 4041 -127
EGR1 -4716 7086 -3070 1893
EGR2 -4735 5299 -972 4747
EIF4B -2849 3070 -3855 5585
EIF4E 4474 5594 818 6719
EIF4EBP1 -1882 3825 2028 4397
EIF4G1 -3029 3207 3785 5764
ELMO1 -2007 4440 -587 939
ELMO2 2276 3622 3753 6108
EP300 -1082 3351 3310 4900
EPAS1 1145 -692 4297 4595
EPN1 -4028 6984 4265 5033
EPOR -1736 710 3981 3155
EPS15 4441 4977 1513 -516
EPS15L1 -2993 7303 2688 2728
EPSTI1 4500 635 -351 293
ERBB2 -3822 7865 -4098 4159
ERLEC1 3019 6261 -53 1240
ESR2 750 1948 -3155 4783
ESRP2 -1561 6352 1841 -276
ESYT1 -1261 4168 -4401 4320
EVL -2581 3789 -3990 7073
EZH2 4420 4467 549 2695
F11R -2053 2359 -96 -1144
FABP5 1248 3657 2416 2233
FADD -32 2272 2169 -329
FAF2 230 7630 1614 2842
FAM135A 2701 2796 -3923 464
FAM13A 3024 2121 2703 1054
FAM13B 1971 5976 -3035 5113
FAM91A1 2734 2883 3013 2501
FARP2 899 1858 -1446 -921
FAS 3890 -122 486 825
FASN -4128 3287 -3015 4277
FBXW7 1395 6293 -812 6665
FER 3913 3144 -132 2567
FES -3914 4107 4416 -1636
FGD3 -1344 5623 3113 1922
FGF9 -3778 6725 -4069 997
FGFBP3 -2051 6094 -73 207
FGFRL1 -788 765 380 5865
FKBP1A 2460 6115 3110 1814
FKBP4 -2065 4659 -2153 2679
FKBP5 -67 1860 4144 -681
FLOT1 -1484 2672 4192 422
FLOT2 -2705 346 3594 5522
FLT3LG -2752 4449 -4476 6675
FMNL1 -3849 1312 3289 3934
FMNL3 -4371 1052 -3602 -90
FNBP1 167 1677 -695 2510
FNTA 4228 7257 -1396 694
FNTB -3255 3928 -150 -1383
FOS -4562 4067 -1568 5645
FOSB -4747 1997 -1043 1975
FOSL1 1165 2684 2346 6222
FOXO1 -3602 816 -4632 3034
FOXO3 -3051 7309 2545 5022
FRAT1 -4020 7600 3994 5690
FRAT2 -1802 6878 3880 4157
FRS2 1396 163 -1740 -882
FRS3 -671 6270 3251 6523
FSTL3 -3658 6483 4457 5263
FURIN -4713 8343 3951 7178
FUZ -4169 6354 1997 -944
FYN -2118 2799 -2956 2793
FZD2 -3064 3465 1563 2618
FZD3 2608 7498 -1959 6060
FZD5 538 8108 4571 2664
FZD6 -2236 8163 -3685 735
FZD7 -387 2387 -2476 2145
FZD8 -4661 7306 -3704 2234
GAB2 -2692 347 3912 2390
GABBR1 1926 573 1062 -1488
GALNT3 3849 7903 1738 -712
GAS8 -3075 6986 1503 -619
GATA3 -395 8146 -4535 6272
GATAD2A -3627 7010 578 189
GATAD2B 628 7335 806 5593
GFOD1 -4662 7820 111 5189
GGA3 -1147 1423 3637 671
GIPR 836 459 -3269 -792
GIT1 -4438 -130 -2072 -1970
GIT2 3531 5943 4323 6160
GLI1 3751 2817 3391 5202
GMIP -639 5398 4537 5867
GNA12 -2122 7455 -1739 4302
GNA13 362 3946 -288 3330
GNA15 -3902 7100 4385 -1922
GNAI2 -1673 5401 4018 3218
GNAI3 2539 700 1964 2359
GNAL -2990 4032 134 3638
GNAQ 2758 3816 2814 -1830
GNAS -815 -274 -206 -60
GNAT1 2745 -386 1928 705
GNB1 -2153 -389 3695 2799
GNB2 -2502 6029 3855 1879
GNB4 3398 8143 2201 1335
GNB5 -441 5776 -2946 6254
GNG2 -335 4273 -1270 6498
GNG3 3186 8362 2852 7139
GNG4 1800 6983 1913 6854
GNG5 2604 3736 4182 6510
GNG7 -1065 -471 -3131 -499
GNGT2 -1574 -71 766 7117
GNRHR2 -1148 2506 653 1263
GOLGA3 -3142 6881 -564 4569
GOLGA7 1327 3410 -2030 3104
GOPC 2386 2686 -3010 2529
GPAM 667 3270 -3712 81
GPR132 -2471 231 187 1930
GPR183 1506 203 -4674 741
GPR35 -4300 -132 3852 -1791
GPR65 2957 7965 1703 3227
GPR68 -2008 5499 -3836 -285
GPS1 -4246 7866 -691 6188
GPS2 -1070 1235 1038 6828
GPSM2 4133 5326 3002 -92
GPSM3 -3955 5655 2193 3761
GRAP2 -2746 6230 -2761 3631
GRB10 561 190 4532 3328
GRB2 29 5972 4230 6239
GRIN2D -2765 8098 3803 3069
GRK5 -2953 992 -2698 6889
GRK6 -4137 5543 2561 3634
GSK3A -2466 4803 3600 2534
GSK3B -92 3624 973 4907
GTF2A1 2577 3931 -1896 1479
GTF2A2 2545 4271 652 286
GTF2F1 -4236 1342 2079 558
GTF2F2 2000 4258 2006 5306
HBEGF -3771 8140 -172 -1006
HDAC1 1651 4891 908 3287
HDAC10 -2989 6333 2136 4923
HDAC11 -640 7740 1067 6082
HDAC2 2465 4575 -3268 5862
HDAC3 -1179 8278 2800 7113
HDAC4 -3577 1775 4019 887
HDAC5 -3319 622 1361 3068
HDAC7 -1539 3799 2058 -487
HEBP1 -1809 1150 2082 314
HGS -803 2229 3794 4350
HHAT 1062 6735 -2744 459
HIF1A 1346 4099 2872 2448
HINT2 -3718 -612 -1604 -607
HMOX2 -3769 699 -4339 6411
HNRNPC 1732 735 1301 213
HNRNPF -3188 3524 -532 5855
HNRNPH1 1863 2157 -1951 2373
HNRNPM -1989 6919 1257 2773
HRAS -3453 1483 -1282 -823
HRH2 2267 7893 4516 -109
HSP90AA1 3100 4857 -2176 6208
HSP90AB1 1227 824 -4305 -1224
HSPB1 -1006 2000 -832 883
HSPE1 -3279 6255 -3450 3593
ICMT -2002 6734 -349 2626
ID1 -4439 5833 1412 5398
ID2 2431 886 4112 1192
ID3 755 -536 -2230 -55
IER3 -892 3420 -1125 1545
IFT122 -2134 5875 1981 3149
IFT140 -4739 95 -2867 5909
IFT172 -1216 83 -1451 -1245
IFT52 -219 4324 -694 320
IFT57 973 2802 1185 1594
IGF1R -4593 253 -291 -1420
IKBKB -1861 958 1970 -912
IKZF1 -2116 4063 -2850 5423
IL1RAP 2063 39 2084 -1120
IL2RA 1014 432 -3039 6866
IL2RB -4721 5850 -4587 7234
IL32 616 212 -4349 7265
IL6R -583 6529 1258 5065
IL6ST 3221 3452 -1202 1708
INCENP -4098 739 -267 5537
INSR -1506 5691 3483 3558
IQGAP1 -6 372 3381 587
IQGAP2 2140 2768 3344 3888
IRS1 -4535 4409 -2997 4307
IRS2 -4076 5285 3498 6150
ITCH 421 6841 732 4853
ITGA2 4300 4000 -2741 -260
ITGAV 2010 3274 3023 -370
ITGB3BP 1027 6242 -4084 -83
ITPR1 -1901 6612 -1565 1789
ITPR2 1162 4456 2298 -44
ITPR3 -748 2875 -2503 2189
ITSN1 3406 5404 4232 3959
JAK1 -3630 6963 -3720 -283
JAK2 4309 6228 1486 6487
JUN -3724 2763 -598 1283
JUNB -4339 4464 541 5017
JUND -4558 7238 -1691 4242
KANK1 -1644 7270 -4394 4095
KAT2A -1815 2972 -3604 1343
KAT2B 3395 625 -758 4028
KAT5 -124 5587 824 1952
KBTBD7 1063 6403 893 -381
KCTD13 -2703 4148 713 638
KCTD3 -1221 8350 2335 6967
KCTD6 2713 7603 2328 -621
KDM1A 830 4049 -2642 5492
KDM1B 3414 1251 2818 -425
KDM3A -2184 -398 -4512 -504
KDM4A 430 3692 2528 3870
KDM4B -3349 4572 3759 1541
KDM4C 961 7526 -790 6225
KHDRBS1 -381 3158 -1780 1137
KIDINS220 615 2130 2750 3650
KIF14 555 2783 145 -596
KIF18A 2515 2110 32 3290
KIF2A -2414 107 -3921 4006
KIF2C 3056 5593 433 -12
KIF3A 1773 3240 -4199 6172
KIF5B 3638 7491 2378 4669
KLC1 -2743 7465 2962 4385
KLC2 -1865 5384 -1364 1505
KLC4 -2811 2807 -494 4366
KLHL12 567 4942 3542 3615
KMT2D -2949 -324 3024 6493
KNTC1 2020 7368 -1851 429
KPNA2 2320 838 -1587 4420
KRAS 4442 4004 1217 3139
KSR1 2326 2619 4333 7144
KTN1 3997 -195 -162 -1504
LAMA2 -3818 5748 -2988 6002
LAMB2 -949 8258 998 1884
LAMTOR1 -4534 -643 3758 -1587
LAMTOR2 -3989 -286 3497 -1340
LAMTOR3 3368 6744 792 957
LAMTOR4 -3934 1904 2799 6998
LAMTOR5 -1370 7060 2866 -881
LATS1 2147 7898 -2219 -841
LATS2 -4528 7644 2126 103
LBR 1834 84 2040 2128
LCK -1825 2493 -4488 7243
LEMD3 -2274 5853 -1591 3474
LEO1 4519 5072 -36 4251
LEPR -628 2384 -136 2863
LETM1 -3997 420 -78 5494
LFNG -2050 6004 2538 6683
LIMK1 -3358 -627 3471 -1748
LIMK2 -897 4599 3050 116
LIN7B -1192 4948 1220 992
LMAN1 3906 722 -4216 5993
LMNB1 3711 4088 4311 1051
LPAR2 -796 3255 4011 -1082
LPAR5 527 1957 -1098 6313
LPAR6 4174 3968 -3751 7273
LRIG1 -1019 -6 -4425 -692
LRP5 -3317 -735 -1511 -123
LRP6 -3961 7937 -4021 1600
LRRC1 -3148 6548 -3837 2539
LRRC41 -454 1095 4215 2878
LTB4R -1334 -771 4397 -1916
LTB4R2 -3435 -553 1725 -1804
LYL1 -2144 1660 3583 -1347
LYPLA1 3374 1200 1311 2159
MAD1L1 -987 962 1357 2466
MAD2L1 2707 1182 -3946 -200
MADD -2282 1840 1338 -1302
MAF1 -4253 5744 610 6179
MAML1 -1765 5619 2743 1442
MAML2 -4166 2210 -3302 4626
MAML3 -2499 8118 4036 3460
MAP2K1 -1421 -148 3921 1533
MAP2K2 -4639 8028 1944 6408
MAP2K5 -1300 6887 1874 3448
MAP3K11 -2226 2565 4171 1270
MAP3K7 2692 3839 1057 -147
MAPK1 -745 2758 4197 6097
MAPK14 1563 2227 4024 2465
MAPK3 -4620 -475 3649 1978
MAPK6 3784 2364 2110 257
MAPK7 -2209 3007 3966 -244
MAPK8 -1037 6156 -3737 4553
MAPKAP1 1208 5508 898 5906
MAPKAPK2 -3939 1416 2421 3265
MAPKAPK3 -1142 58 4580 2896
MAPRE1 2555 -251 1436 -441
MARK3 3935 7732 4259 3805
MBD3 -4266 7251 -2567 6238
MDM2 4264 1085 2091 2095
MED1 -958 5969 -1763 4472
MEF2A 2271 7441 3276 3013
MEF2D -4375 4552 2051 177
MEMO1 2040 7748 2826 1334
MEN1 -3770 2124 -1576 1903
MFN1 1752 444 -1306 1048
MFN2 -4040 4165 2889 -1029
MFNG -4727 4666 -3194 6331
MIB1 -1177 4082 -3646 3187
MIS12 1664 8111 -4237 4936
MKNK1 1175 3261 3743 1392
MKRN1 84 7896 951 2197
MKS1 -918 3887 -2417 4512
MLST8 -2723 3408 89 2258
MOB1B 3975 8129 1502 3562
MOV10 2762 7613 -818 -1880
MSI2 2167 1520 -2356 -1087
MST1 -3918 -200 2746 1923
MST1R -2157 -770 -204 -1883
MTA2 -1792 2504 585 5577
MTA3 -1256 851 -3154 5161
MTMR4 -886 4174 1943 3784
MTOR -3867 1233 454 3900
MTR 540 2999 -3866 6465
MTX1 -3347 7250 4430 -1297
MXD4 -4151 7180 -1221 6705
MYB 1716 530 -1100 -449
MYD88 1536 2750 4540 1945
MYH10 45 3810 2690 5542
MYH9 -3635 3380 2352 6144
MYL6 -3965 4192 3830 2012
MYLIP -1998 4478 -3408 2479
MYO19 722 4532 -344 772
MYO6 2392 7543 -3494 1793
MYO9A 2033 1521 -1534 6336
MYO9B -2080 3138 4362 6775
NAB1 3548 1495 1773 5390
NAB2 -1017 2995 -369 3891
NBEA -2813 8192 -4149 7001
NCBP1 4110 6523 -472 5857
NCBP2 4266 3714 -3787 4776
NCF4 -2178 -141 4210 -1939
NCK1 3861 1096 -4123 1018
NCK2 -4077 2453 -3263 1378
NCKAP1L 650 1928 4458 -320
NCKIPSD -3678 7993 -3134 667
NCOA2 524 7295 1683 2432
NCOA3 2212 6875 2263 3815
NCOR1 935 1094 2216 -530
NCOR2 -4337 576 4446 -1607
NCSTN 1556 -453 4578 1224
NDC80 3297 2974 -2836 4578
NDE1 525 2551 1802 1067
NDEL1 2222 5998 3584 2477
NDUFA5 3294 330 -3396 4944
NDUFS3 -862 191 1131 3397
NEDD4 2622 6200 3146 -1104
NEDD4L -2331 220 3504 -1079
NEDD8 -3865 5558 3129 -105
NELFB -4505 5452 197 -649
NET1 -324 1827 -4037 -1881
NF1 1493 3354 2107 -328
NF2 54 981 522 1410
NFATC1 -3266 6729 -1906 6945
NFKBIA -1959 3670 1551 6812
NLK 3950 792 1270 -208
NLN 2956 2166 2246 6768
NMB -4519 2700 -1421 -273
NOS3 929 4038 -3056 4048
NOTCH1 -3689 2419 2614 6289
NOTCH4 -1388 3909 4488 4961
NOXA1 -2901 6248 -1339 -376
NPHP4 -4051 6688 663 4777
NR1H2 -4065 7065 3532 6461
NR1H3 -2064 8041 2064 6204
NR3C1 94 4233 -1678 3509
NR4A1 798 3379 -1261 1085
NSL1 2683 5615 3221 2273
NSMAF 1814 3286 -1621 3345
NTRK1 1910 8375 -3382 7047
NTSR1 -1171 -343 3488 5435
NUDC -2324 1030 -1794 5031
NUF2 2312 5080 -1802 1198
NUMB 1929 1640 4554 5038
NUP107 2943 1017 -4115 6299
NUP133 2030 1473 -2474 935
NUP160 1232 5781 -4066 1293
NUP37 1488 500 -594 3398
NUP43 3972 139 -3557 6344
NUP85 2428 5395 -713 4517
NUP98 808 1649 64 -747
OBSCN -3124 7215 -3915 191
OPN3 -437 1603 2381 3803
OPRL1 -558 5803 4398 -1820
OS9 78 1591 4372 -313
OSBPL11 2697 736 3760 5618
OTUD3 -86 6186 -2265 5745
OTUD7B -248 3609 -3680 42
OTULIN -947 6637 -430 6430
P2RY1 37 8330 4557 3720
P2RY2 -2303 6659 1355 -485
P4HB -3022 6808 3555 5716
PAFAH1B1 -363 5586 1470 6856
PAG1 -2026 5032 128 6277
PAK1 3393 4953 4129 2452
PAK2 3060 2498 2198 283
PAK4 -2625 774 767 3938
PAQR3 1865 6913 -956 2041
PARD6A -4197 6968 -1350 4618
PARP1 -2044 374 -4291 3582
PCSK5 1564 1704 2130 -869
PDE1B 38 4031 4496 -1312
PDE2A 1821 -752 -1454 -1908
PDE3B 2546 3786 -4286 3507
PDE4A -1204 5896 3653 -975
PDE4B 1302 249 -1989 -866
PDE4C 3658 -263 2608 -932
PDE4D -3168 6391 -373 1999
PDE5A -1393 6846 -1347 3824
PDE6B -2930 5698 -3786 1268
PDE6D -1778 6497 2115 4821
PDE7A 1430 -49 -4528 5611
PDE7B 2277 6816 1180 7260
PDE8A 3107 7639 3086 5315
PDHB 3044 6516 -643 560
PDHX 2415 5258 -500 4891
PDK1 1315 4247 -2152 1824
PDK2 -3844 5774 -2064 3785
PDPK1 -3330 144 2187 346
PEA15 1166 1559 -23 7142
PEAK1 -4494 869 690 4364
PEBP1 180 4782 -4537 4324
PELP1 -637 6658 -3306 2742
PFN1 -2208 2486 3213 3814
PFN2 -2369 8202 -4323 6351
PGF -1573 4534 -259 -1148
PGRMC2 1688 -375 -4322 -310
PHB -3520 6906 -3169 4541
PHC1 -3898 601 -3043 -1211
PHC2 -2965 4301 4364 4886
PHC3 1703 519 -1430 4976
PHIP 4189 5589 235 3484
PHLPP1 -3548 7705 2248 5440
PHLPP2 -4174 7902 -4525 6879
PICALM 2035 2214 3735 -1231
PIK3AP1 131 4960 4137 1373
PIK3CA 2884 3277 -475 1470
PIK3CD -4035 151 2426 6107
PIK3CG 153 2554 2373 2051
PIK3R1 -2132 5137 -4392 6991
PIK3R2 -2279 5345 2344 3831
PIK3R3 2060 3520 1094 3645
PIK3R4 2189 2075 -1855 2170
PIK3R5 -4359 1796 2607 4482
PIN1 -4611 3766 76 4014
PIP4K2A -2845 5429 -2601 3045
PIP4K2B -3801 1202 -3368 1071
PIP4K2C 231 5937 192 223
PIP5K1A -1372 3934 1132 4435
PIP5K1C -4599 8022 2668 3895
PKN1 -3823 7075 2435 6602
PKN2 4258 7317 832 1740
PKN3 -1105 8211 1815 6033
PKP4 339 -302 -2538 -659
PLCB2 -2389 3646 3638 903
PLCB3 -2087 6187 4550 -1266
PLCG1 -749 5789 -3949 958
PLCG2 -1458 6158 3982 2803
PLD1 2370 2188 4049 -902
PLEKHG2 -1690 3006 4518 4271
PLEKHG3 -3487 8181 -3179 -1853
PLIN3 -2513 4565 4504 23
PLK1 -973 4647 1163 3514
PLXND1 -536 6356 4201 -1843
PMEPA1 -3907 8322 -4151 7046
PMF1 64 2344 16 6311
PML 1705 1158 976 4574
POFUT1 862 6485 2967 3622
POLR2A -2661 -175 2387 4046
POLR2B 2791 1490 -2187 5561
POLR2C -1223 4488 -1052 6354
POLR2D 1826 1345 -3754 -614
POLR2E -4070 2983 1998 3712
POLR2F -4130 6520 2177 509
POLR2G -3529 8023 2161 1604
POLR2H -1987 7555 -1495 6297
POLR2I -4150 6339 -662 5655
POLR2K 3699 2452 -1615 3853
POU2F1 3493 5425 2773 3909
PPARD -3413 4443 -3320 -791
PPM1A 1581 7664 1642 -136
PPP1CA -2801 1919 1999 4237
PPP1CB 3663 -225 1118 -340
PPP1CC 4403 3200 1151 5378
PPP1R12A 3602 2867 1723 4509
PPP1R12B 329 3478 2650 4894
PPP1R15A -4741 5629 81 829
PPP2CA 2133 7688 1877 2598
PPP2CB 3173 15 2037 2771
PPP2R1B 1368 607 -1191 6169
PPP2R5A 1917 1224 2809 -230
PPP2R5B -1113 7049 4073 -286
PPP2R5C 1533 5894 -3487 7072
PPP2R5D -1009 5720 986 3470
PPP2R5E 792 2414 -2786 1402
PPP3CA -123 1244 -187 5978
PPP3CB 4151 5256 913 4044
PPP3CC -187 5352 -4405 2384
PPP3R1 579 5005 124 2945
PPP5C -3307 653 -704 5719
PRC1 2508 1113 -276 4461
PRDM4 -836 814 -3144 6114
PREX1 -4427 3449 4064 5228
PRKAA1 3162 5613 -479 607
PRKAB1 2967 3175 3402 -840
PRKAB2 942 4048 -1766 3091
PRKACA -1378 3969 4529 890
PRKACB 559 7713 -4630 1712
PRKAG1 3046 1524 2735 -1054
PRKAG2 2660 5977 -522 1021
PRKAR1A 2205 3898 3721 -432
PRKAR1B -3615 -681 1004 1230
PRKAR2A -740 529 1168 -874
PRKCA -2583 7972 -2473 6892
PRKCB -3677 4193 2655 4963
PRKCD 301 8167 4500 6358
PRKCE -1194 7105 3475 -1183
PRKCH -3115 5155 -4661 2578
PRKCI 1614 7123 -2223 1662
PRKCQ -1185 3922 -4577 4207
PRKCZ -3370 -228 -2888 -1374
PRMT1 -3613 2063 -3476 2118
PROK2 1762 -351 3765 -1989
PRR5 -4233 4574 -4217 -347
PSAP 506 1283 3823 628
PSEN1 2104 1717 4209 4954
PSEN2 -3913 4718 -1419 -162
PSENEN -599 5312 3752 4979
PSMA1 2917 5206 1363 4758
PSMA2 1509 4929 -836 5163
PSMA3 4416 1432 -1823 3586
PSMA5 3047 4175 -2828 3319
PSMA6 3897 6144 1661 6676
PSMA7 -246 5863 3266 6901
PSMB1 -371 2981 -803 5409
PSMB10 -3433 689 -161 6388
PSMB2 835 -501 1803 1518
PSMB3 23 780 3778 4305
PSMB5 -2694 183 3229 269
PSMB6 -3103 5638 3472 5817
PSMB7 -2378 1587 2955 4198
PSMB8 949 1746 2054 5155
PSMB9 -217 3058 -3454 4468
PSMC1 928 2242 2194 1413
PSMC3 -2624 4680 847 736
PSMC4 -1230 1188 537 3431
PSMC5 -1694 2039 -2600 5094
PSMC6 4108 118 1373 2356
PSMD1 2911 5546 2375 56
PSMD11 4009 2032 2637 3521
PSMD12 4511 5250 2167 3681
PSMD13 -998 7807 1482 561
PSMD14 3360 3896 85 6314
PSMD2 -3334 6719 2097 3610
PSMD3 -4637 3063 1629 5579
PSMD4 -1530 1685 3940 5313
PSMD6 1854 3171 3275 2336
PSMD7 3595 864 596 2079
PSMD8 -2435 7747 2069 4665
PSMD9 -3510 -186 3384 3375
PSME1 1353 7210 -2849 1614
PSME2 3304 7208 -1478 778
PSME3 802 6539 2470 5231
PSME4 3349 7885 -461 5908
PSMF1 -1946 2260 416 7179
PTBP1 -4071 1931 -1813 815
PTCH1 -1584 5826 -3069 5606
PTCH2 -4139 -513 -620 -566
PTEN 2106 3654 2736 4814
PTGER2 -1984 7366 -336 -850
PTGER4 -1136 3083 -1238 5864
PTGES3 4122 2723 -1820 4286
PTK2 -814 2487 -1377 -475
PTK2B -3952 4106 4499 4528
PTPN1 -1209 -294 3707 699
PTPN11 -256 3762 1122 5061
PTPN12 608 -601 1634 -982
PTPN13 -4440 8337 -2577 6848
PTPN18 -1734 887 4371 3436
PTPN2 2787 3163 4008 181
PTPN6 -1174 2534 4395 6540
PTPN7 1233 1319 -1494 2323
PTPRA -3242 5260 -362 6356
PTPRJ -2062 6860 3552 7167
PTPRU 3178 -685 2768 -1726
PXN -3681 1377 3188 -814
PYGO2 -1210 7810 -3827 6528
QRFP -1143 4593 1736 -1962
RAB4A 272 2850 -1411 559
RAB4B -2727 7770 3909 4687
RAB6A 3034 6426 2839 3323
RAB7A 837 -522 3489 -124
RAC1 3574 7484 4225 5539
RAC2 -3760 6815 1945 4576
RAC3 -1474 1339 329 827
RACGAP1 3851 3065 2101 4089
RAD21 2425 2676 -2774 5117
RAF1 537 4277 3739 6571
RALA 2197 1756 -3637 2302
RALB 2920 4131 3581 6831
RALBP1 1356 6044 1668 5391
RALGAPA1 1156 1451 -3249 4577
RALGDS -3344 3719 -3219 6404
RANBP10 -1741 7551 1546 5495
RANBP2 2136 4418 -1280 5164
RANBP9 1246 4134 548 884
RANGAP1 -3501 6672 -3795 3626
RAP1A 4512 2607 2624 6567
RAP1B 2749 6134 2033 5966
RAP1GDS1 -1390 247 -2296 3444
RAPGEF1 -3506 6250 1511 6443
RARA -1793 2133 4383 2132
RARG -1979 3347 -1625 297
RASA1 3812 3038 2526 3434
RASA2 3734 493 -1787 2632
RASA3 -3964 3166 -4568 187
RASAL1 -1198 4145 496 5683
RASAL3 -2451 5237 -3104 2544
RASGRP1 500 3237 -4511 5886
RASGRP2 -3881 4893 -1986 -413
RASGRP3 2257 966 -2637 760
RBBP4 2299 2563 -1974 4061
RBBP5 1539 5828 -2066 2829
RBBP6 3635 3405 -1799 2861
RBCK1 20 93 3817 -510
RBL1 -545 3150 -2999 5255
RBPJ 3616 3970 3767 1033
RBX1 1451 6206 1453 5881
RCC2 394 3390 1866 1985
RCE1 -2533 3254 475 3297
RCOR1 -2 4205 3665 -178
RDH10 -2141 299 -2622 262
RDH11 2750 3734 935 4047
RDH13 2629 158 69 -1149
RDH14 -1919 4766 -4419 1087
RELA -4376 5729 -1050 4332
REST 1900 2098 -725 1286
RGL1 3471 934 4142 3381
RGL2 -3199 6351 4074 4878
RGS1 1442 7659 -1449 4457
RGS10 -369 4805 -1987 1143
RGS12 2781 3739 1123 4989
RGS14 -2827 912 2302 1881
RGS16 701 1303 -3074 2518
RGS19 -739 1553 3660 -154
RGS2 -3155 1193 2781 3106
RGS3 -3455 5545 2223 7119
RHEB 3545 6668 1728 6309
RHOA 2796 1879 3280 4033
RHOB 1659 4733 2234 2346
RHOBTB2 -4709 6205 -3612 2104
RHOBTB3 -4744 8281 -4193 1297
RHOF -3403 3511 -4235 6476
RHOG -703 3967 4093 3664
RHOH 474 -207 -4179 5997
RHOQ 3301 -35 1950 -160
RHOT1 4113 2005 4404 5574
RHOT2 -1991 1616 83 5892
RHPN1 -2804 2963 -3930 852
RICTOR 2489 4606 -2585 2833
RING1 -4454 4511 -308 1003
RIT1 1801 2784 3901 2694
RND1 1875 341 2020 780
RNF111 2625 5548 609 6047
RNF146 3169 1909 4368 1611
RNF2 3358 7473 -879 2513
RNF20 1663 527 1389 4637
RNF31 -269 4616 -505 3198
RNF41 -467 2353 4133 4401
ROCK1 4037 2208 2623 2732
RPGRIP1L 2669 1097 -4219 2731
RPS27A -3731 2481 -4078 2589
RPS6 -3204 4732 -4317 361
RPS6KA1 -2393 6272 4241 -1857
RPS6KA2 -3185 6436 -715 2117
RPS6KA5 4173 7351 -3252 1991
RPS6KB2 -2640 6125 1721 4804
RPTOR -2242 -221 -887 5594
RRAGA -1303 8282 3010 6804
RRAGC 3546 6994 -629 5283
RRAGD 839 3965 1919 -1654
RRAS2 159 6738 -3222 6334
RTN4 356 2232 4258 2901
RUNX1 2495 3257 3425 193
RUNX3 -3366 4812 -4197 6758
RUVBL1 -126 6075 -3589 4750
RYK 550 5532 -4255 4957
S1PR1 -19 -331 -3578 6789
S1PR2 -295 7000 -3123 3081
S1PR4 -4036 7910 1679 5357
SAMM50 -2834 4556 -709 6079
SAV1 824 3004 -1237 -1154
SCAI 3702 3232 -3310 1276
SCD 1361 4076 1056 -1081
SCMH1 -2646 7070 -3805 95
SCRIB -4609 7517 1035 -1416
SEC13 -1298 7330 2552 6209
SEH1L 3665 6621 -4109 3577
SEL1L 1724 2862 1817 4058
SEMA4F -3074 5649 -3862 5603
SENP1 3010 4831 -1829 1369
SFN -2816 -551 990 -1777
SFPQ -474 6432 -1479 3947
SGK1 -4707 3673 -2318 -1192
SH2B1 -1908 4860 -1276 1436
SH2B3 -2452 3414 3520 3851
SH2D2A -1750 3792 -2767 6507
SH3BP1 -3920 -10 934 7097
SH3GL1 -3765 6412 3499 6038
SH3PXD2A -4596 6304 -3648 469
SHARPIN -4213 4116 2719 4877
SHB -1155 4525 2903 6642
SHC1 47 7294 2954 3205
SHKBP1 -2562 6602 4408 4502
SHMT2 -635 788 -220 1900
SHOC2 2321 7643 904 34
SIRT6 -1900 6690 3481 6643
SKA2 3969 3193 -1415 2113
SKI -1514 2376 -2042 2897
SKIL 3155 3949 2557 3946
SKP1 3454 3180 -2543 2680
SLC1A5 -3846 3875 1271 -1348
SLC38A9 1594 6413 2203 6115
SLC4A7 3216 7560 -3501 6613
SLK 1467 3806 798 -1623
SMAD1 1668 3536 4577 206
SMAD2 3578 1109 1380 1865
SMAD3 -571 5305 -2989 -363
SMAD4 3753 772 -2633 -1923
SMAD5 1837 546 -2259 221
SMAD6 3527 8078 3978 5258
SMAD7 -4228 4704 -1899 1420
SMARCA4 -3629 2881 2224 6790
SMC3 4148 4947 -2524 623
SMPD2 -4259 6605 2755 6782
SMPD3 -3342 695 -2822 7223
SMURF1 -765 197 1222 6932
SMURF2 1161 4750 -3814 3523
SNAP23 2642 7973 1694 -471
SNW1 3539 3975 580 2517
SOCS1 3263 5646 2492 4130
SOCS3 -4725 693 4095 6490
SOS1 3053 3267 -1345 -1984
SOS2 2591 87 3354 3699
SOX4 2827 7080 2455 4438
SP1 -240 2139 3000 4864
SPATA13 -476 2331 -736 5995
SPC24 304 5456 37 3603
SPDL1 -959 -325 -4393 480
SPEN -2283 7318 1811 3750
SPOP 3532 3781 -1872 39
SPOPL 2510 3417 1980 -1203
SPPL2A 4217 -438 3288 1613
SPPL2B -3357 6684 -424 4260
SPRED1 3813 6853 3232 6063
SPRED2 -607 7006 4028 5461
SPRED3 1851 7863 1940 5936
SPRY1 -3384 2708 -3280 2310
SPRY2 -2593 5045 -1452 1690
SPTAN1 -4171 369 -4508 -407
SPTBN1 -3552 7730 -4056 3657
SPTBN5 3170 2471 2062 2256
SQSTM1 -3391 1301 -1278 658
SRC -1769 -92 -2399 -1474
SREBF1 -2674 5362 -317 2475
SRF -3394 1012 2578 2816
SRGAP1 2640 7361 3647 -15
SRGAP3 2456 2138 1839 -351
SRRM1 4398 6138 -860 3813
ST3GAL3 -2618 3495 -2215 5835
ST3GAL4 -4201 2588 3030 -1349
ST3GAL6 3418 8393 1394 6717
STAG1 28 2900 -2922 5282
STAM 1450 1971 -1016 6489
STAM2 4057 4699 1834 3301
STARD13 -1965 461 1418 7246
STAT1 3698 949 -4441 4969
STAT3 1049 7062 3091 4994
STAT5A -3150 -563 3416 -1543
STAT5B -2600 7765 1731 1495
STAT6 -2092 3383 4260 3854
STBD1 785 6119 -200 -658
STIP1 -931 -119 -1327 362
STK10 -3634 3470 2725 -688
STK11 -4042 2650 -14 750
STK3 2476 4607 3547 265
STK38 1684 810 1424 46
STK4 -275 6487 -797 -11
STMN1 2231 4278 -4034 3009
STOM 312 -756 1358 -1584
STRADA 2763 3990 2986 3716
STRADB 2924 3992 763 1425
STRAP 2529 1218 -157 5451
STRN -1473 3594 1793 6483
STUB1 -4241 3481 -957 2320
STX5 -2844 3219 3004 5924
SUFU -3419 1922 4329 3621
SYDE2 -3164 7359 -4299 6279
SYK 927 3885 3853 431
SYNGAP1 -4106 6607 -3128 1191
SYVN1 422 4723 3011 -846
TAB2 1280 -849 -1462 6399
TACC3 -3903 5302 3122 5484
TAGAP -1609 428 -4598 3486
TAOK1 553 -211 2303 7110
TAOK3 2739 991 1567 118
TAX1BP1 4184 1932 1345 1037
TBL1XR1 4074 1360 546 2633
TCF12 -194 -80 620 -542
TCF7 -3466 7591 -4677 6949
TCF7L2 4370 2006 4568 1660
TCIRG1 -2526 4545 4576 1353
TEC 1638 2871 4185 170
TERT 1645 728 -2709 7278
TEX2 -3163 1187 2324 -1025
TFDP1 3198 468 1695 2953
TFDP2 -3609 3755 -4460 -1476
TFRC 3790 8109 1195 -131
TGFA -2177 7641 3789 4631
TGFB1 -3576 4335 -268 3769
TGFBR1 2006 5247 -1233 -1262
TGFBR2 -3560 6665 212 2870
TGIF1 -1589 430 -2345 -390
TGIF2 -592 2244 -3370 -1903
THBS3 -483 6566 3928 -662
THEM4 -569 8295 -4563 809
TIA1 4400 2295 -823 2854
TIAL1 4260 6121 -1199 5519
TIAM2 3277 7166 483 -1145
TJP2 3895 7175 4490 4716
TLE2 -2549 3325 -4592 1969
TLE3 -2897 6937 4303 3113
TLE4 1191 7248 3715 5137
TLN1 -3596 2096 3346 -983
TLR9 -3285 -405 -837 7201
TMED2 3441 4473 377 5944
TMED5 4484 4966 2098 1678
TMEM59 1982 5198 2537 2439
TMEM87A 4068 1720 -1598 -1316
TMOD3 4331 5248 3022 6413
TMPO 3021 6678 3274 5173
TNF 3685 -672 -2015 -526
TNFAIP1 1423 4774 3864 3483
TNFAIP3 -2738 1870 -572 6103
TNFRSF10A 240 4911 -1359 2821
TNFRSF10B -1038 4835 2879 -670
TNFRSF10D -3781 2595 2566 3086
TNFRSF1A -757 1590 4369 -1546
TNFSF10 4078 1289 1846 369
TNKS 1639 7205 -839 4476
TNKS2 1426 2722 -55 2960
TNRC6A 3327 6066 302 5196
TNRC6B 88 782 -383 7057
TOR1AIP1 3030 2655 1187 4214
TP53 -1807 1985 -4011 2709
TPM3 2491 5210 3418 6503
TPM4 -1072 178 2060 633
TRADD -2077 2054 -2911 5247
TRAF1 470 -802 -3415 6213
TRAF2 40 5279 -2998 5763
TRAF6 878 6544 -562 -71
TRAK2 26 227 -3000 -32
TRIB3 -565 560 -565 3767
TRIM27 1860 5342 3869 5497
TRIM33 3725 4285 -575 6678
TRIO -2951 8385 2140 6816
TRRAP -3007 7355 -1336 6326
TSC1 -514 6027 1193 4695
TSC2 -3080 5070 1798 3951
TTC21B 2210 5214 -1736 3389
TUBA1B 828 3584 2491 4759
TULP3 -468 6392 -3050 3709
TWF1 4136 -170 -77 2316
TXNL1 2795 1315 1506 5741
TYK2 -2482 1902 4365 4072
UBA52 -3208 4386 -596 -69
UBB -2084 561 -996 5058
UBC -1739 2624 1876 3220
UBE2D1 1930 4687 3454 2741
UBE2D3 3202 2444 2392 3005
UBE2M -4705 5150 1539 2052
UBXN11 -1181 5119 2484 2973
UCHL5 3769 646 -4054 2394
UHMK1 248 7132 -2142 4667
UHRF1BP1L 2925 3741 3703 723
USF1 -1162 3081 4039 3193
USF2 -4702 88 2385 1718
USP13 1082 5443 -462 2905
USP15 2966 1178 287 4186
USP21 -85 2204 87 -293
USP34 -399 3650 -586 1573
USP4 -96 3346 4160 -254
USP7 -1481 1987 813 3259
USP8 4434 6334 2439 4109
VAMP3 1811 2454 2982 619
VAPA 2045 3824 3031 4245
VAPB 875 8196 -2226 -1987
VAV1 -2612 6923 3874 5832
VAV2 -832 7700 2796 4133
VAV3 -4054 8267 2141 -685
VCL -1153 1830 476 3614
VCP -2285 7849 1665 1908
VEGFA -3059 827 1628 87
VHL -1365 2716 227 5208
VIM -1688 3605 4349 3780
VIPR1 -961 1734 -2661 5971
VPS26A 3855 5918 1660 4070
VPS29 3878 2615 3058 688
VPS35 4116 -495 1632 -1445
VRK2 4167 3119 306 2179
VRK3 1695 5188 2478 2903
WASF1 -547 758 4502 -830
WASF2 -2160 1232 3929 -134
WASL 2751 7375 -567 4644
WDR11 3731 3251 2160 3347
WDR19 1380 1960 -2575 -150
WDR35 1931 6696 -1365 -219
WDR6 -1968 543 -1384 -476
WDR81 -3805 5462 -810 3580
WDR83 -3019 8035 2820 5496
WDR91 -3386 5584 359 5671
WHAMM 941 6893 -4132 2748
WIPF1 -2325 2893 -1463 -784
WIPF2 655 565 2515 -1017
WNT1 -2105 7642 -3730 2325
WNT2B -857 2500 3108 3566
WWOX -4433 81 -3515 4711
WWP1 3419 4683 -4565 479
WWP2 -1758 4226 3996 2916
XPO1 4384 5608 -1759 6845
YBX1 -2060 4522 -183 6423
YES1 677 -619 -2471 5197
YKT6 -3493 -250 2413 3314
YWHAB 4207 4074 788 2152
YWHAE 2448 6182 3206 1288
YWHAG -1658 5656 3774 1919
YWHAH 1174 3456 3029 -1274
YWHAQ 972 1310 -2670 3225
YWHAZ 3562 2726 -278 4293
YY1 -4104 2745 -3291 1468
ZAP70 -4216 1398 -4044 7248
ZDHHC21 -1138 2885 -2127 427
ZDHHC7 -1187 5373 3335 4795
ZFYVE16 3850 7982 3257 4516
ZFYVE9 -1988 3517 -4599 3529
ZNF217 585 2083 1072 2921
ZNRF3 -2783 7733 -3017 3859
ZW10 3450 4438 -1152 -591
ZWILCH 3714 4716 -2155 835
ZWINT 1434 899 -2659 6102





Signaling by Receptor Tyrosine Kinases

Signaling by Receptor Tyrosine Kinases
metric value
setSize 284
pMANOVA 3.13e-10
p.adjustMANOVA 4.55e-10
s.dist 0.246
s.t0_crp_RNA -0.0898
s.t0_crp_meth 0.0417
s.pod_crp_RNA 0.222
s.pod_crp_meth 0.033
p.t0_crp_RNA 0.00983
p.t0_crp_meth 0.231
p.pod_crp_RNA 1.58e-10
p.pod_crp_meth 0.343



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA t0_crp_RNA
FURIN 3951 -4713
PTK2B 4499 -3952
FES 4416 -3914
EPN1 4265 -4028
MAPK3 3649 -4620
DNM2 3699 -4239
IRS2 3498 -4076
AP2A1 4575 -2927
SH3GL1 3499 -3765
ADAP1 4077 -3123
CYBA 4087 -2911
CSK 3950 -2994
ATP6V0B 4040 -2906
PXN 3188 -3681
TCIRG1 4576 -2526
AP2M1 2737 -4018
STAT5A 3416 -3150
MST1 2746 -3918
RAB4B 3909 -2727
GAB2 3912 -2692

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
AAMP -4607 1163 -1372 7118
ABI1 4121 520 2868 3253
ABI2 570 1453 -3567 -206
ADAM10 2914 3590 3423 2760
ADAM17 3217 4696 4464 4154
ADAP1 -3123 5370 4077 -1539
ADORA2A -997 8333 -974 7183
AHCYL1 1297 6888 1605 2692
AKT1 -4471 4213 2297 1109
AKT2 -4622 3462 2041 5430
AP2A1 -2927 1888 4575 -316
AP2M1 -4018 5714 2737 3723
AP2S1 -1597 3981 3589 6037
APH1A -3566 1656 857 -119
APH1B 3237 2583 3451 6783
ARF6 -1265 6257 -355 3741
ARHGEF7 -4633 957 532 330
ATF1 4365 685 1579 2989
ATP6V0A1 -73 5522 4481 -1569
ATP6V0A2 1039 5229 -2100 6651
ATP6V0B -2906 4920 4040 5502
ATP6V0C -819 2497 4204 2933
ATP6V0D1 -717 5801 4411 6934
ATP6V0E1 -98 5534 3098 1836
ATP6V0E2 688 -8 -3868 -1325
ATP6V1A 2260 3916 3165 -1495
ATP6V1B2 1335 2965 3679 -1553
ATP6V1C1 3195 3435 3307 6757
ATP6V1D 3158 446 3682 1096
ATP6V1E1 3127 6210 2844 4775
ATP6V1F -2969 2955 1967 -699
ATP6V1G2 -783 7744 -3696 3740
ATP6V1H 2094 5695 1932 2559
BAIAP2 -3214 6287 -510 2757
BAX -2161 -40 3408 1161
BRAF 968 80 165 -1524
BRK1 -4091 8027 -825 3071
CALM1 1287 3980 -2201 4501
CAV1 244 7711 -1532 4591
CBL -1090 7589 3285 1012
CDC42 3320 7040 2741 856
CDK5 -142 4633 4463 3491
CDK5R1 -2189 7694 -1862 7121
CHD4 -1845 1886 -1491 640
CHEK1 2868 3127 -2668 51
CLTA 185 1469 2876 -546
CLTC 461 2670 3511 7256
COL9A2 1701 1714 427 4443
CREB1 2387 5046 -1542 1422
CRK 3068 5936 3523 6596
CRKL -1398 7466 -102 5166
CSK -2994 1998 3950 4889
CTNNB1 2009 6708 3025 5069
CTNND1 4227 2980 1662 -1707
CUL5 4190 5397 -1036 344
CYBA -2911 5359 4087 2019
CYFIP1 644 8297 4331 256
CYFIP2 -1585 4227 -2032 6157
DIAPH1 -659 5118 910 2371
DLG4 -1306 281 4191 2607
DNAL4 -4067 5461 -269 2609
DNM1 2874 2154 2211 1607
DNM2 -4239 6583 3699 3063
DOCK7 2335 7606 -1154 2327
DUSP3 -328 6561 3398 2260
DUSP4 1176 3581 -1089 2494
DUSP6 -534 7727 -1313 -1941
DUSP7 -2585 6442 -1315 722
EGR1 -4716 7086 -3070 1893
EGR2 -4735 5299 -972 4747
ELMO1 -2007 4440 -587 939
ELMO2 2276 3622 3753 6108
EP300 -1082 3351 3310 4900
EPN1 -4028 6984 4265 5033
EPS15 4441 4977 1513 -516
EPS15L1 -2993 7303 2688 2728
ERBB2 -3822 7865 -4098 4159
ESRP2 -1561 6352 1841 -276
FER 3913 3144 -132 2567
FES -3914 4107 4416 -1636
FGF9 -3778 6725 -4069 997
FGFBP3 -2051 6094 -73 207
FGFRL1 -788 765 380 5865
FLT3LG -2752 4449 -4476 6675
FOS -4562 4067 -1568 5645
FOSB -4747 1997 -1043 1975
FOSL1 1165 2684 2346 6222
FRS2 1396 163 -1740 -882
FRS3 -671 6270 3251 6523
FURIN -4713 8343 3951 7178
FYN -2118 2799 -2956 2793
GAB2 -2692 347 3912 2390
GALNT3 3849 7903 1738 -712
GGA3 -1147 1423 3637 671
GRAP2 -2746 6230 -2761 3631
GRB10 561 190 4532 3328
GRB2 29 5972 4230 6239
GTF2F1 -4236 1342 2079 558
GTF2F2 2000 4258 2006 5306
HBEGF -3771 8140 -172 -1006
HGS -803 2229 3794 4350
HNRNPF -3188 3524 -532 5855
HNRNPH1 1863 2157 -1951 2373
HNRNPM -1989 6919 1257 2773
HRAS -3453 1483 -1282 -823
HSP90AA1 3100 4857 -2176 6208
HSPB1 -1006 2000 -832 883
ID1 -4439 5833 1412 5398
ID2 2431 886 4112 1192
ID3 755 -536 -2230 -55
IGF1R -4593 253 -291 -1420
INSR -1506 5691 3483 3558
IRS1 -4535 4409 -2997 4307
IRS2 -4076 5285 3498 6150
ITCH 421 6841 732 4853
ITGA2 4300 4000 -2741 -260
ITGAV 2010 3274 3023 -370
ITPR1 -1901 6612 -1565 1789
ITPR2 1162 4456 2298 -44
ITPR3 -748 2875 -2503 2189
JAK2 4309 6228 1486 6487
JUNB -4339 4464 541 5017
JUND -4558 7238 -1691 4242
KIDINS220 615 2130 2750 3650
KRAS 4442 4004 1217 3139
LAMA2 -3818 5748 -2988 6002
LAMB2 -949 8258 998 1884
LCK -1825 2493 -4488 7243
LRIG1 -1019 -6 -4425 -692
LYL1 -2144 1660 3583 -1347
MAP2K1 -1421 -148 3921 1533
MAP2K2 -4639 8028 1944 6408
MAP2K5 -1300 6887 1874 3448
MAPK1 -745 2758 4197 6097
MAPK14 1563 2227 4024 2465
MAPK3 -4620 -475 3649 1978
MAPK7 -2209 3007 3966 -244
MAPKAP1 1208 5508 898 5906
MAPKAPK2 -3939 1416 2421 3265
MAPKAPK3 -1142 58 4580 2896
MEF2A 2271 7441 3276 3013
MEF2D -4375 4552 2051 177
MEMO1 2040 7748 2826 1334
MKNK1 1175 3261 3743 1392
MLST8 -2723 3408 89 2258
MST1 -3918 -200 2746 1923
MST1R -2157 -770 -204 -1883
MTOR -3867 1233 454 3900
MXD4 -4151 7180 -1221 6705
NAB1 3548 1495 1773 5390
NAB2 -1017 2995 -369 3891
NCBP1 4110 6523 -472 5857
NCBP2 4266 3714 -3787 4776
NCF4 -2178 -141 4210 -1939
NCK1 3861 1096 -4123 1018
NCK2 -4077 2453 -3263 1378
NCKAP1L 650 1928 4458 -320
NCOR1 935 1094 2216 -530
NCSTN 1556 -453 4578 1224
NEDD4 2622 6200 3146 -1104
NELFB -4505 5452 197 -649
NOS3 929 4038 -3056 4048
NTRK1 1910 8375 -3382 7047
PAG1 -2026 5032 128 6277
PAK1 3393 4953 4129 2452
PAK2 3060 2498 2198 283
PCSK5 1564 1704 2130 -869
PDE3B 2546 3786 -4286 3507
PDPK1 -3330 144 2187 346
PGF -1573 4534 -259 -1148
PIK3CA 2884 3277 -475 1470
PIK3R1 -2132 5137 -4392 6991
PIK3R2 -2279 5345 2344 3831
PIK3R3 2060 3520 1094 3645
PIK3R4 2189 2075 -1855 2170
PLCG1 -749 5789 -3949 958
POLR2A -2661 -175 2387 4046
POLR2B 2791 1490 -2187 5561
POLR2C -1223 4488 -1052 6354
POLR2D 1826 1345 -3754 -614
POLR2E -4070 2983 1998 3712
POLR2F -4130 6520 2177 509
POLR2G -3529 8023 2161 1604
POLR2H -1987 7555 -1495 6297
POLR2I -4150 6339 -662 5655
POLR2K 3699 2452 -1615 3853
PPP2CA 2133 7688 1877 2598
PPP2CB 3173 15 2037 2771
PPP2R1B 1368 607 -1191 6169
PPP2R5D -1009 5720 986 3470
PRKACA -1378 3969 4529 890
PRKACB 559 7713 -4630 1712
PRKCA -2583 7972 -2473 6892
PRKCB -3677 4193 2655 4963
PRKCD 301 8167 4500 6358
PRKCE -1194 7105 3475 -1183
PRKCZ -3370 -228 -2888 -1374
PRR5 -4233 4574 -4217 -347
PSEN1 2104 1717 4209 4954
PSEN2 -3913 4718 -1419 -162
PSENEN -599 5312 3752 4979
PTBP1 -4071 1931 -1813 815
PTK2 -814 2487 -1377 -475
PTK2B -3952 4106 4499 4528
PTPN1 -1209 -294 3707 699
PTPN11 -256 3762 1122 5061
PTPN12 608 -601 1634 -982
PTPN18 -1734 887 4371 3436
PTPN2 2787 3163 4008 181
PTPN6 -1174 2534 4395 6540
PTPRJ -2062 6860 3552 7167
PTPRU 3178 -685 2768 -1726
PXN -3681 1377 3188 -814
RAB4A 272 2850 -1411 559
RAB4B -2727 7770 3909 4687
RAC1 3574 7484 4225 5539
RALA 2197 1756 -3637 2302
RALB 2920 4131 3581 6831
RALGDS -3344 3719 -3219 6404
RANBP10 -1741 7551 1546 5495
RANBP9 1246 4134 548 884
RAP1A 4512 2607 2624 6567
RAP1B 2749 6134 2033 5966
RAPGEF1 -3506 6250 1511 6443
RASA1 3812 3038 2526 3434
REST 1900 2098 -725 1286
RHOA 2796 1879 3280 4033
RICTOR 2489 4606 -2585 2833
RIT1 1801 2784 3901 2694
RNF41 -467 2353 4133 4401
ROCK1 4037 2208 2623 2732
RPS27A -3731 2481 -4078 2589
RPS6KA1 -2393 6272 4241 -1857
RPS6KA2 -3185 6436 -715 2117
RPS6KA5 4173 7351 -3252 1991
SGK1 -4707 3673 -2318 -1192
SH2B3 -2452 3414 3520 3851
SH2D2A -1750 3792 -2767 6507
SH3GL1 -3765 6412 3499 6038
SHB -1155 4525 2903 6642
SHC1 47 7294 2954 3205
SOCS1 3263 5646 2492 4130
SOS1 3053 3267 -1345 -1984
SPRED1 3813 6853 3232 6063
SPRED2 -607 7006 4028 5461
SPRY1 -3384 2708 -3280 2310
SPRY2 -2593 5045 -1452 1690
SRC -1769 -92 -2399 -1474
SRF -3394 1012 2578 2816
STAM 1450 1971 -1016 6489
STAM2 4057 4699 1834 3301
STAT1 3698 949 -4441 4969
STAT3 1049 7062 3091 4994
STAT5A -3150 -563 3416 -1543
STAT5B -2600 7765 1731 1495
STAT6 -2092 3383 4260 3854
STMN1 2231 4278 -4034 3009
STUB1 -4241 3481 -957 2320
TAB2 1280 -849 -1462 6399
TCF12 -194 -80 620 -542
TCIRG1 -2526 4545 4576 1353
TEC 1638 2871 4185 170
TGFA -2177 7641 3789 4631
THBS3 -483 6566 3928 -662
THEM4 -569 8295 -4563 809
TIA1 4400 2295 -823 2854
TIAL1 4260 6121 -1199 5519
TLR9 -3285 -405 -837 7201
TRIB3 -565 560 -565 3767
UBA52 -3208 4386 -596 -69
UBB -2084 561 -996 5058
UBC -1739 2624 1876 3220
USP8 4434 6334 2439 4109
VAV1 -2612 6923 3874 5832
VAV2 -832 7700 2796 4133
VAV3 -4054 8267 2141 -685
VEGFA -3059 827 1628 87
VRK3 1695 5188 2478 2903
WASF1 -547 758 4502 -830
WASF2 -2160 1232 3929 -134
WWOX -4433 81 -3515 4711
WWP1 3419 4683 -4565 479
YES1 677 -619 -2471 5197
YWHAB 4207 4074 788 2152





Metabolism of lipids

Metabolism of lipids
metric value
setSize 427
pMANOVA 1.54e-09
p.adjustMANOVA 2.05e-09
s.dist 0.196
s.t0_crp_RNA 0.0238
s.t0_crp_meth 0.0708
s.pod_crp_RNA 0.178
s.pod_crp_meth -0.0371
p.t0_crp_RNA 0.406
p.t0_crp_meth 0.0134
p.pod_crp_RNA 5.1e-10
p.pod_crp_meth 0.194



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA t0_crp_meth
TSPO 4356 8405
TBXAS1 4545 8037
PTGR1 4399 7913
ARF1 3973 8373
PNPLA2 3887 8230
ELOVL1 3947 8049
INPPL1 4370 7266
HACD1 3681 8376
GLB1 4196 7186
SLC22A5 3641 8228
GBA2 3596 8286
GLTP 3764 7906
FADS1 3941 7417
DGAT2 4220 6825
SYNJ1 3923 7273
ACAA1 4528 6265
GM2A 4388 6404
GPCPD1 3720 7389
ARSB 3997 6851
CHKA 3935 6928

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
AACS -2934 6857 595 5128
ABCA1 -336 7231 2025 -82
ABCC1 -878 1823 2916 -26
ABHD3 4503 4050 3828 2912
ABHD4 -2895 4770 1607 574
ABHD5 2414 720 3748 1319
ACAA1 -1087 6265 4528 5788
ACACA -1025 4834 2969 1077
ACACB -992 5485 -2409 -519
ACAD10 -366 2194 3884 2091
ACAD11 3947 2774 -892 5732
ACADM 3683 2043 -2322 -637
ACADS -4517 3056 2984 -1450
ACAT1 2850 5731 -1590 4901
ACAT2 200 2827 -3791 777
ACBD4 -311 1764 -514 1001
ACBD5 1401 6073 837 2753
ACBD6 -4390 6462 -1187 372
ACBD7 2873 6300 2309 4803
ACER2 -1152 657 -2186 315
ACER3 3165 4460 3761 6814
ACLY -1395 2347 3652 2976
ACOT13 4388 3371 3074 2379
ACOT7 -3802 7581 -3120 6018
ACOT8 -2950 3829 4183 5474
ACOX1 2556 4662 3143 4104
ACOX3 -1435 2160 3862 5380
ACOXL 1905 -167 2104 7257
ACP6 -436 6932 -3041 5125
ACSF2 2420 8240 1759 3532
ACSF3 -2263 4822 2021 4103
ACSL1 2623 4187 4181 6605
ACSL3 3668 2010 2511 -732
ACSL5 2379 -549 -595 2404
ACSL6 -495 -639 -4529 7275
ACSM3 -1430 7940 -3308 698
AGK 934 6016 -3178 492
AGPAT1 -2691 6624 1516 5847
AGPAT2 -3761 -328 4455 -1386
AGPAT3 106 -470 3507 637
AGPAT4 -1618 5516 4054 -315
AGPAT5 1206 2572 -4517 5437
AGPS 2974 3777 70 -195
AHR -1326 394 972 5026
AHRR 1569 786 1332 6736
AKR1B1 -3686 2318 -4483 4189
ALDH3A2 545 7647 54 5653
ALOX5 330 6127 4345 5385
ALOX5AP 18 3560 2870 -1564
AMACR -1685 7544 -1477 6128
ARF1 -3573 8373 3973 -1819
ARF3 -2676 4360 3215 274
ARNT 2436 4997 3382 4408
ARNTL 161 5741 1664 1097
ARSA 1972 -580 3635 523
ARSB 1416 6851 3997 -1526
ARSG 1116 6606 -2210 4004
ARSK -1236 5160 -4588 4078
ARV1 3428 8073 1416 6969
ASAH1 2991 3487 4461 2174
BDH1 -2974 7846 -4389 796
BDH2 4220 1517 -3963 -1581
CAV1 244 7711 -1532 4591
CBR4 2569 7281 118 2046
CCNC 4378 2184 -3183 4187
CDIPT -4672 1917 1674 2141
CDK19 -939 744 3385 975
CDK8 2364 2319 1443 5793
CDS2 -3463 5871 1701 540
CEPT1 4293 846 469 169
CERK -4498 -371 -3531 -203
CERS5 3350 5417 2105 -1208
CERS6 -52 4237 783 -762
CHD9 681 6114 58 -1053
CHKA -438 6928 3935 -1257
CHKB 882 -26 1574 6849
CHPT1 1608 -366 2646 -1712
CLOCK 2754 6463 -1399 3525
CPNE1 -1872 4807 -478 5131
CPNE3 1598 2499 -94 -1441
CPT1A 1125 24 2235 -1596
CPT2 3437 4039 4343 -446
CPTP -2608 8308 -400 5329
CRAT -4282 6500 2610 2473
CREBBP -4011 6807 2122 892
CRLS1 1486 3891 1348 6321
CSNK1G2 -4686 6801 1934 2563
CSNK2A2 769 3941 1687 5734
CSNK2B 63 7476 2450 4742
CTSA -2481 2086 4047 2720
CYP2R1 1968 4391 -857 3262
CYP2U1 -294 3597 -4327 3858
CYP46A1 4031 1270 382 3979
CYP4F22 4276 -384 1509 5601
CYP51A1 2889 2950 2708 -89
DBI -3593 589 3790 1598
DDHD1 1480 8212 -2346 4147
DDHD2 1071 4710 -4117 687
DECR1 3916 2634 3730 3217
DECR2 -4183 4461 -175 3974
DEGS1 -1317 4783 -164 3203
DGAT1 -3399 6428 2057 -576
DGAT2 -2590 6825 4220 -892
DHCR24 307 2363 3902 -1293
DHCR7 -1035 6443 1545 4808
DHRS7B 17 2460 4328 345
DPEP2 -1068 5051 1433 -1336
ECHS1 -2339 4561 -2157 3252
ECI1 -3919 5905 -429 -1281
ECI2 1155 925 -4398 296
EHHADH 2714 8210 3258 2918
ELOVL1 -720 8049 3947 6600
ELOVL4 -3374 7721 -4684 3377
ELOVL5 2410 4241 891 2656
ELOVL6 -2262 3265 -2261 521
EP300 -1082 3351 3310 4900
EPHX2 -1239 2671 -4649 -695
ESRRA -3861 5908 4164 5420
ESYT1 -1261 4168 -4401 4320
ESYT2 -2666 2986 -4141 1696
ETNK1 4099 7514 -1405 5866
FABP5 1248 3657 2416 2233
FADS1 2266 7417 3941 3002
FADS2 163 4013 2147 -779
FAM120B 3990 7523 2933 -222
FAR1 3903 4781 3644 313
FASN -4128 3287 -3015 4277
FDFT1 -2022 6806 2858 3920
FDPS -1076 3888 2704 4337
FDX1 3757 5874 -1143 3052
FDXR -793 3298 2267 1657
FIG4 3298 5946 4203 6857
FITM2 -317 1668 -3561 910
GALC 2125 2765 4394 4244
GBA -641 3501 4492 45
GBA2 -2573 8286 3596 -583
GDE1 1552 7324 2785 5339
GDPD1 727 4224 -651 3142
GDPD5 1788 4425 -2204 235
GGPS1 4310 4454 -2058 541
GGT1 -199 -722 4581 -1935
GLB1 890 7186 4196 1828
GLIPR1 3846 390 2195 5591
GLTP -3108 7906 3764 -1008
GM2A 2719 6404 4388 6361
GPAM 667 3270 -3712 81
GPCPD1 2628 7389 3720 7100
GPD1 -712 2273 880 -633
GPD1L -172 6926 -3760 -403
GPD2 2544 4768 3077 -1556
GPS2 -1070 1235 1038 6828
GPX1 -4323 2175 1937 -875
GPX4 -1077 5325 429 4418
GSTM4 -2320 4514 2571 2362
HACD1 3549 8376 3681 -1443
HACD2 693 8147 -2803 6435
HACD3 1104 8183 -4444 3440
HACD4 2341 -111 672 6324
HACL1 3083 3195 -4194 3807
HADH -838 5834 -3992 -364
HADHA -1343 7276 861 2805
HADHB 2912 2675 4007 3179
HDAC3 -1179 8278 2800 7113
HEXA -1721 6917 -195 5237
HEXB 1519 7559 2594 2906
HILPDA 3960 6174 -185 1618
HMGCL 1633 474 4069 6681
HMGCR 1410 4917 2277 4521
HMGCS1 3099 7126 -701 3457
HPGD 1508 8359 2593 6952
HSD17B1 -2463 946 -242 2592
HSD17B11 2654 1196 1244 5770
HSD17B12 2682 2568 1013 5882
HSD17B4 2879 2691 3666 2004
HSD17B8 299 1496 -2297 5821
IDI1 4084 5263 2106 2766
INPP4A -3687 2941 754 5040
INPP5D -3830 1160 2964 55
INPP5E -504 6651 -2118 496
INPP5F 2862 497 2831 3598
INPP5K -2009 5479 250 2453
INPPL1 -2826 7266 4370 588
INSIG1 2968 -618 2262 3015
INSIG2 4050 4605 1493 -1217
KPNB1 2659 5901 -47 1140
LBR 1834 84 2040 2128
LCLAT1 2375 4609 -1712 4862
LGMN -2484 6373 -3917 2706
LIPE -2433 7826 -3775 5507
LPCAT1 -2710 -419 1992 1418
LPCAT3 423 2859 4216 1514
LPCAT4 -530 3708 -367 2192
LPGAT1 1637 4533 2937 -464
LPIN1 2863 5858 -2364 2315
LPIN2 -1129 5541 -2981 6917
LSS -3485 2482 -2915 -719
LTA4H 2233 5699 4301 798
LTC4S -3824 5088 -399 -1872
MAPKAPK2 -3939 1416 2421 3265
MBOAT1 1904 5207 2756 500
MBOAT7 -3078 2649 4057 4178
MBTPS1 -1260 2396 3174 2401
MCAT -4499 7924 449 4955
MCEE 4246 5577 420 1366
MECR -2210 4505 -987 6052
MED1 -958 5969 -1763 4472
MED10 -634 434 -3398 2697
MED11 601 2720 2070 5167
MED13 -27 6634 -1506 6578
MED13L -613 3804 2892 5938
MED15 -1967 632 150 5801
MED16 -1417 6758 775 -884
MED17 2502 1171 -2481 3538
MED18 1381 -577 2731 -268
MED19 -350 266 2423 2674
MED20 334 3800 2922 180
MED21 2584 7622 -1434 4075
MED22 -4548 6176 -835 -1306
MED23 2395 2524 160 3755
MED24 -3004 4336 1028 5182
MED25 -1368 5836 3323 565
MED26 -4409 4968 962 3021
MED27 -1097 2235 -20 1874
MED28 3792 6036 233 219
MED29 -3028 3169 -1717 -373
MED30 -1702 1813 -2527 4135
MED31 4462 8011 -815 2499
MED4 3667 1149 -134 127
MED6 4430 6997 -3117 6743
MED7 4299 448 -229 4940
MED8 3318 5166 3046 1234
MED9 -582 4019 -968 1721
MFSD2A -531 2949 -1633 -1141
MLYCD 311 6207 423 3456
MMAA 3491 2901 -2978 6864
MORC2 -967 2360 -3748 7281
MSMO1 4372 4656 -112 5194
MTF1 1815 2946 3779 5710
MTMR10 2793 8268 2553 6803
MTMR12 -684 -115 -805 4653
MTMR14 -362 509 3627 3137
MTMR2 1371 7201 -2594 1909
MTMR3 -3015 252 4249 613
MTMR4 -886 4174 1943 3784
MTMR6 3040 740 1804 2060
MTMR9 3090 5006 956 4285
MVD -4655 8400 568 190
MVK -1106 6687 -1041 3791
NCOA2 524 7295 1683 2432
NCOA3 2212 6875 2263 3815
NCOA6 -633 756 3510 419
NCOR1 935 1094 2216 -530
NCOR2 -4337 576 4446 -1607
NDUFAB1 224 1036 -1391 4045
NEU1 660 3057 4459 1899
NEU3 -1522 5675 -59 -1013
NFYA -229 2632 244 102
NFYB 2887 7845 -4590 1588
NFYC 1959 3116 4374 226
NR1D1 -4546 4990 -4400 5905
NR1H2 -4065 7065 3532 6461
NR1H3 -2064 8041 2064 6204
NRF1 -3554 6245 -1559 -1255
NUDT19 1053 476 2290 6784
NUDT7 2933 4547 965 3989
ORMDL1 3074 7662 -248 5780
ORMDL3 -3219 2570 -3756 3085
OSBP 113 3073 -1605 370
OSBPL2 -810 3710 2978 2403
OSBPL3 44 1664 -3898 1202
OSBPL5 -4265 7408 -459 -1846
OSBPL7 -853 1395 -2203 -1675
OSBPL8 924 6560 1126 4415
OSBPL9 3631 3421 1538 3235
OXCT1 852 3309 -4502 3313
PCCB -3642 3525 -2599 -1151
PCTP -203 8290 2877 6636
PCYT1A 2595 5831 2440 5271
PCYT2 -4539 6132 -3087 -368
PECR -3991 4676 2603 6199
PEMT 164 6747 -809 5570
PEX11A -102 340 1034 3970
PGS1 -3032 126 4063 -1356
PHOSPHO1 -254 6798 2930 5609
PI4K2A -2983 521 2456 5680
PI4K2B 4343 2560 -4426 2370
PI4KA -2340 4504 1071 2317
PI4KB -1197 4376 1286 5394
PIAS4 -3106 7583 3432 1744
PIK3CA 2884 3277 -475 1470
PIK3CD -4035 151 2426 6107
PIK3CG 153 2554 2373 2051
PIK3R1 -2132 5137 -4392 6991
PIK3R2 -2279 5345 2344 3831
PIK3R3 2060 3520 1094 3645
PIK3R4 2189 2075 -1855 2170
PIK3R5 -4359 1796 2607 4482
PIKFYVE 964 425 1379 -725
PIP4K2A -2845 5429 -2601 3045
PIP4K2B -3801 1202 -3368 1071
PIP4K2C 231 5937 192 223
PIP5K1A -1372 3934 1132 4435
PIP5K1C -4599 8022 2668 3895
PISD -2298 -204 4389 -888
PITPNB 4312 4434 -2584 4751
PITPNM1 -2867 98 4344 3850
PITPNM2 -1264 -196 -1617 7238
PITPNM3 1658 8209 325 6588
PLA2G12A 979 7679 -3083 767
PLA2G15 -736 3451 4553 3624
PLA2G4C -4738 1015 -1071 3866
PLA2G6 -4368 2559 -2235 826
PLB1 -1294 2623 4541 -114
PLD1 2370 2188 4049 -902
PLD3 -2550 2237 2394 354
PLD6 -4388 2910 -4550 5489
PLEKHA2 -404 1913 -51 -1135
PLEKHA3 3080 8398 -1496 -1379
PLEKHA6 2169 4176 543 -1432
PLEKHA8 452 1505 -971 -788
PLIN2 720 4594 3934 1747
PLIN3 -2513 4565 4504 23
PMVK -3316 3746 2151 3437
PNPLA2 -3351 8230 3887 281
PNPLA6 -2610 5843 4136 2173
PNPLA7 300 2886 -1035 1447
PNPLA8 3994 6714 1910 -143
PON2 -2138 3921 -1480 -1454
PPARD -3413 4443 -3320 -791
PPARGC1B -2385 -738 1265 1449
PPM1L -3193 3613 1369 6863
PPP1CA -2801 1919 1999 4237
PPP1CB 3663 -225 1118 -340
PPP1CC 4403 3200 1151 5378
PPT1 2459 3088 4279 1132
PPT2 -3883 1900 -3365 -1407
PRKAB2 942 4048 -1766 3091
PRKACA -1378 3969 4529 890
PRKACB 559 7713 -4630 1712
PRKAG2 2660 5977 -522 1021
PRKD2 -2036 6873 520 5528
PSAP 506 1283 3823 628
PTDSS2 -1819 265 945 2429
PTEN 2106 3654 2736 4814
PTGES2 -4318 -433 -1375 -901
PTGES3 4122 2723 -1820 4286
PTGR1 2072 7913 4399 183
PTGR2 -2131 2992 1577 -1415
PTPMT1 349 6638 1692 -467
PTPN13 -4440 8337 -2577 6848
RAB14 3720 1861 1150 -378
RAB4A 272 2850 -1411 559
RAB5A 4303 1753 1458 3958
RAN 1899 2279 -3437 1483
RGL1 3471 934 4142 3381
RORA -1351 7045 -4542 6931
RUFY1 -1808 1436 633 317
SACM1L 3084 4304 -3507 2312
SAMD8 2313 3984 2052 -1766
SAR1B 4471 7978 1753 3060
SBF1 -3967 5806 -2669 3727
SC5D 4408 5856 -649 -891
SCAP -4244 613 -1085 -731
SCD 1361 4076 1056 -1081
SCP2 3265 8303 -726 6349
SEC23A 2416 6271 707 1833
SEC24A 2469 2022 2595 4761
SEC24B 3316 7026 1710 -13
SEC24C -1756 902 2641 -336
SEC24D 2700 6653 3967 1527
SGMS1 2541 6159 2842 4255
SGPL1 -1108 -159 3608 -1014
SGPP1 1936 3665 -906 -665
SIN3A -1818 1522 -4181 3819
SIN3B -1353 -269 1099 -419
SLC22A5 -3486 8228 3641 5706
SLC25A1 -2882 4287 2535 4557
SLC25A17 1107 2275 -3583 -379
SLC25A20 1422 3412 4017 4786
SLC27A1 -4635 7193 2204 1124
SLC27A2 3534 3271 -3276 -1409
SLC27A3 -1699 -464 1680 7016
SLC27A5 -2286 -511 2002 -1572
SLC44A1 2127 3778 1049 924
SLC44A2 -3555 1449 11 4322
SMPD1 -3400 5378 -519 6500
SMPD2 -4259 6605 2755 6782
SMPD3 -3342 695 -2822 7223
SP1 -240 2139 3000 4864
SPHK2 -4338 6514 2891 670
SPTLC1 3925 5882 3329 3337
SPTLC2 1561 7798 2780 1289
SPTLC3 3149 817 280 -1648
SPTSSA 2232 8159 -2801 -193
SQLE 2788 5897 3784 -1593
SRD5A1 1921 6813 3905 6930
SRD5A3 3644 2415 3931 2696
SREBF1 -2674 5362 -317 2475
SREBF2 -1747 3394 3575 4295
STARD10 1094 6276 -681 3166
STARD3 -4273 5383 3347 3852
STARD3NL 623 1119 1840 2506
STARD4 3787 3256 2185 -100
STARD5 -3378 637 2388 1237
STARD7 1617 6852 1400 5187
SUMF1 459 2152 3328 -728
SUMF2 -1913 105 -2949 38
SYNJ1 3931 7273 3923 2804
SYNJ2 -3841 2785 -4552 -505
TBL1XR1 4074 1360 546 2633
TBXAS1 181 8037 4545 -1851
TECR -375 7027 -3159 5768
THEM4 -569 8295 -4563 809
TIAM2 3277 7166 483 -1145
TM7SF2 -3526 1411 -1972 1399
TNFAIP8 1885 1282 -4310 4922
TNFAIP8L1 -3062 584 -2646 1829
TNFAIP8L2 557 5756 1294 -165
TRIB3 -565 560 -565 3767
TSPO -2725 8405 4356 6745
TXNRD1 1650 211 3064 -1400
UBE2I -2546 3641 225 5794
UGCG 3035 -30 722 3873
VAC14 -4335 2856 2485 2508
VAPA 2045 3824 3031 4245
VAPB 875 8196 -2226 -1987
VDR 2207 2682 4559 3980





Signaling by ROBO receptors

Signaling by ROBO receptors
metric value
setSize 153
pMANOVA 3.43e-09
p.adjustMANOVA 4.22e-09
s.dist 0.323
s.t0_crp_RNA -0.214
s.t0_crp_meth -0.0172
s.pod_crp_RNA -0.186
s.pod_crp_meth 0.153
p.t0_crp_RNA 5.15e-06
p.t0_crp_meth 0.715
p.pod_crp_RNA 7.75e-05
p.pod_crp_meth 0.00116



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene t0_crp_RNA pod_crp_RNA
RPS2 -4698 -4571
RPL3 -4508 -4610
RPLP2 -4667 -3815
RPS5 -4113 -4065
RPS12 -4261 -3896
RPLP0 -4068 -4060
RPL27A -4061 -3904
RPS3 -3753 -4143
RPS27A -3731 -4078
RPS16 -4379 -3448
RPL29 -3990 -3643
RPS10 -4168 -3457
RPL37 -4723 -2971
RPL35 -3999 -3508
RPS29 -4598 -3034
RPS18 -4218 -3284
RPS6 -3204 -4317
RPL18A -3938 -3444
NCK2 -4077 -3263
RPS23 -3376 -3858

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
ABL1 -3241 5957 1585 2469
ABL2 -280 4972 -684 5307
ARHGAP39 -711 8384 -176 6947
CAP1 497 5559 3138 2034
CASC3 -2211 3328 2647 5105
CDC42 3320 7040 2741 856
CLASP1 -3321 3273 513 2114
CLASP2 221 2879 -2004 -77
CUL2 4307 5990 178 2207
CXCR4 -69 6662 -926 -1433
DAG1 -2173 2752 937 -94
EIF4A3 -2476 5309 -384 4597
EIF4G1 -3029 3207 3785 5764
ETF1 3017 7097 1676 151
EVL -2581 3789 -3990 7073
FAU -4223 5971 -437 6875
GSPT1 2757 4351 -2932 -1153
LDB1 -3986 4788 -1318 1166
MYO9B -2080 3138 4362 6775
NCBP1 4110 6523 -472 5857
NCBP2 4266 3714 -3787 4776
NCK1 3861 1096 -4123 1018
NCK2 -4077 2453 -3263 1378
NTN1 -1444 8203 -348 4888
PABPC1 1721 3723 -1442 3011
PAK1 3393 4953 4129 2452
PAK2 3060 2498 2198 283
PAK4 -2625 774 767 3938
PFN1 -2208 2486 3213 3814
PFN2 -2369 8202 -4323 6351
PPP3CB 4151 5256 913 4044
PRKACA -1378 3969 4529 890
PRKACB 559 7713 -4630 1712
PRKAR2A -740 529 1168 -874
PRKCA -2583 7972 -2473 6892
PSMA1 2917 5206 1363 4758
PSMA2 1509 4929 -836 5163
PSMA3 4416 1432 -1823 3586
PSMA5 3047 4175 -2828 3319
PSMA6 3897 6144 1661 6676
PSMA7 -246 5863 3266 6901
PSMB1 -371 2981 -803 5409
PSMB10 -3433 689 -161 6388
PSMB2 835 -501 1803 1518
PSMB3 23 780 3778 4305
PSMB5 -2694 183 3229 269
PSMB6 -3103 5638 3472 5817
PSMB7 -2378 1587 2955 4198
PSMB8 949 1746 2054 5155
PSMB9 -217 3058 -3454 4468
PSMC1 928 2242 2194 1413
PSMC3 -2624 4680 847 736
PSMC4 -1230 1188 537 3431
PSMC5 -1694 2039 -2600 5094
PSMC6 4108 118 1373 2356
PSMD1 2911 5546 2375 56
PSMD11 4009 2032 2637 3521
PSMD12 4511 5250 2167 3681
PSMD13 -998 7807 1482 561
PSMD14 3360 3896 85 6314
PSMD2 -3334 6719 2097 3610
PSMD3 -4637 3063 1629 5579
PSMD4 -1530 1685 3940 5313
PSMD6 1854 3171 3275 2336
PSMD7 3595 864 596 2079
PSMD8 -2435 7747 2069 4665
PSMD9 -3510 -186 3384 3375
PSME1 1353 7210 -2849 1614
PSME2 3304 7208 -1478 778
PSME3 802 6539 2470 5231
PSME4 3349 7885 -461 5908
PSMF1 -1946 2260 416 7179
RAC1 3574 7484 4225 5539
RBX1 1451 6206 1453 5881
RHOA 2796 1879 3280 4033
RNPS1 -2473 2186 -3151 537
RPL10A -2021 3601 -3665 3590
RPL11 -2195 4759 -3631 -495
RPL13 -2399 2561 -2415 6187
RPL13A -2217 1446 -4059 5521
RPL14 -2732 1645 -4433 -798
RPL15 -2979 2857 -3337 1424
RPL17 -3043 1594 -3926 2296
RPL18 -3380 7714 -3552 4478
RPL18A -3938 751 -3444 4254
RPL22 -2825 5674 -4182 1020
RPL23 -1858 5701 -3100 2729
RPL23A 48 7818 -4430 4559
RPL26 -2272 4855 -3465 6407
RPL26L1 -972 2107 2314 3971
RPL27A -4061 5311 -3904 1697
RPL28 -2225 2129 -798 4754
RPL29 -3990 4921 -3643 2875
RPL3 -4508 360 -4610 6751
RPL31 -3651 495 -3411 -34
RPL32 -3564 4776 -3623 5998
RPL34 -904 906 -3944 6513
RPL35 -3999 2909 -3508 4823
RPL36 -4523 -158 -2815 2877
RPL36AL -4195 7236 -1732 6350
RPL37 -4723 3433 -2971 5392
RPL37A -3969 1847 -2033 4981
RPL38 -4417 4342 -2941 4430
RPL39L -2468 4218 -28 5079
RPL4 -2456 997 -4254 1394
RPL41 -3631 4792 -2682 821
RPL6 466 3352 -3950 1979
RPL7 -2841 5004 -4292 7008
RPL8 -4442 7620 -2781 5093
RPL9 -990 4307 -3377 844
RPLP0 -4068 5078 -4060 4850
RPLP1 -4307 4259 -1607 1521
RPLP2 -4667 3685 -3815 6421
RPS10 -4168 2356 -3457 3925
RPS11 -3884 1199 -3013 4224
RPS12 -4261 7672 -3896 6329
RPS15 -3350 1899 -2308 5621
RPS15A -3437 1657 -3621 6110
RPS16 -4379 4270 -3448 5979
RPS18 -4218 4809 -3284 4162
RPS19 -3954 1402 -2451 -362
RPS2 -4698 -704 -4571 6973
RPS20 -1234 4742 -3936 3461
RPS23 -3376 -353 -3858 2986
RPS24 -35 6157 -2288 -518
RPS25 -2395 138 -4129 1797
RPS26 -1529 6099 -2398 5515
RPS27A -3731 2481 -4078 2589
RPS27L 3563 2925 1087 1405
RPS28 -4025 17 -2863 -1178
RPS29 -4598 3919 -3034 5600
RPS3 -3753 4053 -4143 4598
RPS3A 1196 4024 -4365 7066
RPS5 -4113 3314 -4065 6070
RPS6 -3204 4732 -4317 361
RPS7 -2809 3926 -3695 4407
RPS8 -1253 -347 -3213 -79
RPS9 -3353 1940 922 627
RPSA 1973 687 -1923 2072
SLIT1 -1399 4555 3673 -1568
SOS1 3053 3267 -1345 -1984
SOS2 2591 87 3354 3699
SRC -1769 -92 -2399 -1474
SRGAP1 2640 7361 3647 -15
SRGAP3 2456 2138 1839 -351
UBA52 -3208 4386 -596 -69
UBB -2084 561 -996 5058
UBC -1739 2624 1876 3220
UPF2 3948 4005 -99 3840
UPF3A -1847 6389 -3579 6961
USP33 4141 -214 -734 774
VASP -1291 3413 3718 1142
ZSWIM8 -3912 4663 4003 -1419





Signaling by Interleukins

Signaling by Interleukins
metric value
setSize 263
pMANOVA 4.28e-08
p.adjustMANOVA 4.89e-08
s.dist 0.217
s.t0_crp_RNA -0.038
s.t0_crp_meth -0.00527
s.pod_crp_RNA 0.182
s.pod_crp_meth 0.111
p.t0_crp_RNA 0.292
p.t0_crp_meth 0.884
p.pod_crp_RNA 4.3e-07
p.pod_crp_meth 0.00212



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA pod_crp_meth
NOD2 4498 6608
TNFRSF1B 4281 6868
PTPN6 4395 6540
ITGB2 4253 6424
PTPN9 4448 6094
SOCS3 4095 6490
GRB2 4230 6239
MAPK1 4197 6097
ALOX5 4345 5385
CRK 3523 6596
VAV1 3874 5832
PSMA7 3266 6901
IRS2 3498 6150
PSMD4 3940 5313
IL19 2850 7263
PTK2B 4499 4528
P4HB 3555 5716
PSMB6 3472 5817
MUC1 2987 6713
SOD2 3199 6132

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
AIP -4146 1494 -31 6682
AKT1 -4471 4213 2297 1109
ALOX5 330 6127 4345 5385
APP -1029 7569 1303 6621
ARF1 -3573 8373 3973 -1819
ATF1 4365 685 1579 2989
BATF -1671 2924 1438 6677
BCL2 891 55 -3102 7020
BCL2L1 168 5903 -129 5968
BCL6 -1059 973 4510 3669
BIRC5 2315 6240 -142 1965
BRWD1 817 -90 -2860 -349
BTRC -2069 66 -3130 -923
CANX 1285 7328 -533 3479
CAPZA1 4166 7801 2992 999
CASP1 4199 -379 2331 7029
CASP3 4360 3118 1576 5689
CBL -1090 7589 3285 1012
CCND1 -2434 3555 -1529 1006
CCR1 2329 4664 3112 -1919
CD4 -528 5984 -2076 909
CDC42 3320 7040 2741 856
CDKN1A 1249 7552 1225 2427
CEBPD -2296 1317 3893 -907
CFL1 -3249 4059 3672 1646
CHUK 2695 2702 2681 1111
CISH 3901 4706 292 4927
CNN2 -1565 2034 1954 -418
CREB1 2387 5046 -1542 1422
CRK 3068 5936 3523 6596
CRKL -1398 7466 -102 5166
CSF1 916 1541 -2144 356
CTF1 -2377 7037 825 543
CUL1 4355 1572 -4161 -1190
CXCL2 -4220 7587 1113 -1988
DUSP3 -328 6561 3398 2260
DUSP4 1176 3581 -1089 2494
DUSP6 -534 7727 -1313 -1941
DUSP7 -2585 6442 -1315 722
FBXW11 -1449 8406 480 -1506
FOS -4562 4067 -1568 5645
FOXO1 -3602 816 -4632 3034
FOXO3 -3051 7309 2545 5022
FYN -2118 2799 -2956 2793
GAB2 -2692 347 3912 2390
GATA3 -395 8146 -4535 6272
GRB2 29 5972 4230 6239
GSDMD -2417 4172 1671 -91
GSTO1 347 7221 3900 3633
HIF1A 1346 4099 2872 2448
HMGB1 1943 2521 -3489 3222
HNRNPA2B1 1271 2586 2367 2721
HNRNPF -3188 3524 -532 5855
HSP90AA1 3100 4857 -2176 6208
HSP90B1 4301 7702 -1893 2127
HSPA9 -243 5862 -4493 6549
ICAM1 -1757 6181 1880 2036
IKBKB -1861 958 1970 -912
IL10RA -2658 3506 605 5516
IL10RB 2492 1088 4296 -1075
IL12A 1447 2118 -2780 -1315
IL12RB1 -2291 -670 -1696 6630
IL12RB2 -4567 1065 -4043 -1859
IL15 1769 6831 1135 3611
IL15RA 3307 3533 2179 -1086
IL16 -3248 4110 -2267 5457
IL17C -2577 -487 3055 -1128
IL17RA 388 5913 4322 130
IL17RC -3722 7073 -539 1939
IL18BP 1389 -326 316 -1638
IL18R1 -2304 7423 850 6742
IL19 2005 -683 2850 7263
IL1RAP 2063 39 2084 -1120
IL21R -2031 2004 -3090 2722
IL23A 1948 -668 -4551 7076
IL27RA 295 4390 2711 6657
IL2RA 1014 432 -3039 6866
IL2RB -4721 5850 -4587 7234
IL32 616 212 -4349 7265
IL4R -494 -410 3746 1274
IL6R -583 6529 1258 5065
IL6ST 3221 3452 -1202 1708
INPP5D -3830 1160 2964 55
INPPL1 -2826 7266 4370 588
IRAK2 -3547 7809 -2980 4685
IRAK3 1420 2776 4357 666
IRF4 2179 4585 -3146 5939
IRS1 -4535 4409 -2997 4307
IRS2 -4076 5285 3498 6150
ITGB2 -4211 745 4253 6424
JAK1 -3630 6963 -3720 -283
JAK2 4309 6228 1486 6487
JUN -3724 2763 -598 1283
JUNB -4339 4464 541 5017
LCK -1825 2493 -4488 7243
LCP1 1687 4158 3798 4311
LGALS9 3366 3238 4298 -1460
LMNB1 3711 4088 4311 1051
MAP2K1 -1421 -148 3921 1533
MAP2K3 -2498 38 3714 2411
MAP2K4 1784 3155 1767 4763
MAP2K6 3151 2164 3939 4791
MAP2K7 -4193 2092 431 1764
MAP3K3 -3332 2306 4125 3121
MAP3K7 2692 3839 1057 -147
MAP3K8 826 6359 4551 3266
MAPK1 -745 2758 4197 6097
MAPK14 1563 2227 4024 2465
MAPK3 -4620 -475 3649 1978
MAPK7 -2209 3007 3966 -244
MAPK8 -1037 6156 -3737 4553
MAPK9 -260 1152 -2605 157
MAPKAPK2 -3939 1416 2421 3265
MAPKAPK3 -1142 58 4580 2896
MEF2A 2271 7441 3276 3013
MIF -3715 2437 -3047 3355
MTAP 2432 8029 -2882 2271
MUC1 -1022 6782 2987 6713
MYD88 1536 2750 4540 1945
NFKB2 -128 2515 499 5250
NFKBIA -1959 3670 1551 6812
NFKBIB -4043 4651 2779 5572
NKIRAS1 -1254 4201 -3568 348
NKIRAS2 -2892 2008 4410 -1130
NOD1 702 2037 268 -321
NOD2 948 2355 4498 6608
OSM -4108 1297 161 1355
P4HB -3022 6808 3555 5716
PAK2 3060 2498 2198 283
PDCD4 3138 54 -4445 4219
PELI1 829 1534 725 1867
PELI2 -80 8419 1276 7033
PELI3 -4660 3884 4288 -1121
PIK3CA 2884 3277 -475 1470
PIK3CD -4035 151 2426 6107
PIK3R1 -2132 5137 -4392 6991
PIK3R2 -2279 5345 2344 3831
PIK3R3 2060 3520 1094 3645
PIM1 -708 2982 1290 1390
PITPNA 512 1692 3198 3616
POU2F1 3493 5425 2773 3909
PPIA -239 5602 -1924 4554
PPP2CA 2133 7688 1877 2598
PPP2CB 3173 15 2037 2771
PPP2R1B 1368 607 -1191 6169
PPP2R5D -1009 5720 986 3470
PRKACA -1378 3969 4529 890
PRTN3 -4653 8354 -2832 5619
PSMA1 2917 5206 1363 4758
PSMA2 1509 4929 -836 5163
PSMA3 4416 1432 -1823 3586
PSMA5 3047 4175 -2828 3319
PSMA6 3897 6144 1661 6676
PSMA7 -246 5863 3266 6901
PSMB1 -371 2981 -803 5409
PSMB10 -3433 689 -161 6388
PSMB2 835 -501 1803 1518
PSMB3 23 780 3778 4305
PSMB5 -2694 183 3229 269
PSMB6 -3103 5638 3472 5817
PSMB7 -2378 1587 2955 4198
PSMB8 949 1746 2054 5155
PSMB9 -217 3058 -3454 4468
PSMC1 928 2242 2194 1413
PSMC3 -2624 4680 847 736
PSMC4 -1230 1188 537 3431
PSMC5 -1694 2039 -2600 5094
PSMC6 4108 118 1373 2356
PSMD1 2911 5546 2375 56
PSMD11 4009 2032 2637 3521
PSMD12 4511 5250 2167 3681
PSMD13 -998 7807 1482 561
PSMD14 3360 3896 85 6314
PSMD2 -3334 6719 2097 3610
PSMD3 -4637 3063 1629 5579
PSMD4 -1530 1685 3940 5313
PSMD6 1854 3171 3275 2336
PSMD7 3595 864 596 2079
PSMD8 -2435 7747 2069 4665
PSMD9 -3510 -186 3384 3375
PSME1 1353 7210 -2849 1614
PSME2 3304 7208 -1478 778
PSME3 802 6539 2470 5231
PSME4 3349 7885 -461 5908
PSMF1 -1946 2260 416 7179
PTK2B -3952 4106 4499 4528
PTPN11 -256 3762 1122 5061
PTPN12 608 -601 1634 -982
PTPN13 -4440 8337 -2577 6848
PTPN18 -1734 887 4371 3436
PTPN2 2787 3163 4008 181
PTPN23 -1373 3838 2730 5426
PTPN4 -398 1836 -4481 784
PTPN6 -1174 2534 4395 6540
PTPN7 1233 1319 -1494 2323
PTPN9 -858 2987 4448 6094
RALA 2197 1756 -3637 2302
RAP1B 2749 6134 2033 5966
RAPGEF1 -3506 6250 1511 6443
RBX1 1451 6206 1453 5881
RELA -4376 5729 -1050 4332
RORA -1351 7045 -4542 6931
RPLP0 -4068 5078 -4060 4850
RPS27A -3731 2481 -4078 2589
RPS6KA1 -2393 6272 4241 -1857
RPS6KA2 -3185 6436 -715 2117
RPS6KA5 4173 7351 -3252 1991
S1PR1 -19 -331 -3578 6789
SHC1 47 7294 2954 3205
SIGIRR -3514 8336 -2448 6805
SKP1 3454 3180 -2543 2680
SMAD3 -571 5305 -2989 -363
SMARCA4 -3629 2881 2224 6790
SNRPA1 1550 6067 -2069 1539
SOCS1 3263 5646 2492 4130
SOCS2 1601 6635 -1294 6477
SOCS3 -4725 693 4095 6490
SOCS5 -415 3620 -1558 466
SOD1 90 6446 -2571 1838
SOD2 177 6323 3199 6132
SOS1 3053 3267 -1345 -1984
SOS2 2591 87 3354 3699
SQSTM1 -3391 1301 -1278 658
STAT1 3698 949 -4441 4969
STAT2 3596 3473 1612 5931
STAT3 1049 7062 3091 4994
STAT4 1560 3811 -4377 4202
STAT5A -3150 -563 3416 -1543
STAT5B -2600 7765 1731 1495
STAT6 -2092 3383 4260 3854
STX1A -1885 1038 248 4173
STX3 371 5386 3443 2712
STX4 -1332 4490 3053 1609
STXBP2 -623 7943 4521 -155
SYK 927 3885 3853 431
TAB2 1280 -849 -1462 6399
TALDO1 -497 2943 4000 4421
TBK1 4522 6493 2094 599
TCP1 2342 2222 -2270 -448
TEC 1638 2871 4185 170
TGFB1 -3576 4335 -268 3769
TNF 3685 -672 -2015 -526
TNFRSF1A -757 1590 4369 -1546
TNFRSF1B -1307 1250 4281 6868
TNIP2 -2442 793 2575 287
TOLLIP -3659 1231 2911 664
TP53 -1807 1985 -4011 2709
TRAF6 878 6544 -562 -71
TXLNA 937 8130 839 7005
TYK2 -2482 1902 4365 4072
UBA52 -3208 4386 -596 -69
UBB -2084 561 -996 5058
UBC -1739 2624 1876 3220
UBE2N 3397 6741 -1303 4833
UBE2V1 2034 4568 -1420 2792
VAMP2 258 533 -3262 -1237
VAV1 -2612 6923 3874 5832
VEGFA -3059 827 1628 87
VIM -1688 3605 4349 3780
VRK3 1695 5188 2478 2903
YES1 677 -619 -2471 5197
YWHAZ 3562 2726 -278 4293
ZEB1 325 6286 -3849 5935





Cytokine Signaling in Immune system

Cytokine Signaling in Immune system
metric value
setSize 424
pMANOVA 1.02e-07
p.adjustMANOVA 1.08e-07
s.dist 0.166
s.t0_crp_RNA 0.0761
s.t0_crp_meth -0.0169
s.pod_crp_RNA 0.102
s.pod_crp_meth 0.105
p.t0_crp_RNA 0.00802
p.t0_crp_meth 0.556
p.pod_crp_RNA 0.000396
p.pod_crp_meth 0.000249



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_meth pod_crp_RNA
NOD2 6608 4498
TNFRSF1B 6868 4281
PTPN6 6540 4395
PRKCD 6358 4500
ITGB2 6424 4253
PTPN9 6094 4448
TRIM8 6373 4202
SOCS3 6490 4095
GRB2 6239 4230
SLA 6984 3680
MAPK1 6097 4197
PTPRJ 7167 3552
ALOX5 5385 4345
SAMHD1 6189 3768
CRK 6596 3523
VAV1 5832 3874
PSMA7 6901 3266
EIF4G1 5764 3785
IRS2 6150 3498
PSMD4 5313 3940

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
AAAS -638 2718 243 1467
ABCE1 3662 2890 -4608 6004
ABL2 -280 4972 -684 5307
ADAM17 3217 4696 4464 4154
ADAR 2970 5925 1386 3087
AIP -4146 1494 -31 6682
AKT1 -4471 4213 2297 1109
AKT2 -4622 3462 2041 5430
ALOX5 330 6127 4345 5385
APP -1029 7569 1303 6621
ARF1 -3573 8373 3973 -1819
ARIH1 2666 5821 -1008 3751
ATF1 4365 685 1579 2989
B2M 3496 3645 -3314 -9
BATF -1671 2924 1438 6677
BCL2 891 55 -3102 7020
BCL2L1 168 5903 -129 5968
BCL2L11 72 5304 2972 5662
BCL6 -1059 973 4510 3669
BIRC2 4449 4494 -741 6624
BIRC3 3504 588 -4618 4816
BIRC5 2315 6240 -142 1965
BRWD1 817 -90 -2860 -349
BST2 1250 -703 383 -1933
BTRC -2069 66 -3130 -923
CAMK2D -1499 3793 -4469 -529
CAMK2G 943 31 471 6716
CANX 1285 7328 -533 3479
CAPZA1 4166 7801 2992 999
CASP1 4199 -379 2331 7029
CASP3 4360 3118 1576 5689
CBL -1090 7589 3285 1012
CCND1 -2434 3555 -1529 1006
CCR1 2329 4664 3112 -1919
CD4 -528 5984 -2076 909
CD44 498 4392 3154 4897
CDC42 3320 7040 2741 856
CDKN1A 1249 7552 1225 2427
CDKN1B -532 1651 -3401 3367
CEBPD -2296 1317 3893 -907
CFL1 -3249 4059 3672 1646
CHUK 2695 2702 2681 1111
CISH 3901 4706 292 4927
CNN2 -1565 2034 1954 -418
CREB1 2387 5046 -1542 1422
CRK 3068 5936 3523 6596
CRKL -1398 7466 -102 5166
CSF1 916 1541 -2144 356
CSK -2994 1998 3950 4889
CTF1 -2377 7037 825 543
CUL1 4355 1572 -4161 -1190
CUL5 4190 5397 -1036 344
CXCL2 -4220 7587 1113 -1988
DDX58 4465 2907 -3747 185
DUSP3 -328 6561 3398 2260
DUSP4 1176 3581 -1089 2494
DUSP6 -534 7727 -1313 -1941
DUSP7 -2585 6442 -1315 722
EDARADD 1265 7621 -3682 6839
EGR1 -4716 7086 -3070 1893
EIF2AK2 4506 187 169 683
EIF4A1 568 5332 2238 881
EIF4A2 3750 5307 -4415 3601
EIF4A3 -2476 5309 -384 4597
EIF4E 4474 5594 818 6719
EIF4E2 -432 2798 2567 5874
EIF4E3 4105 -720 3038 -661
EIF4G1 -3029 3207 3785 5764
EIF4G2 1621 6211 552 6371
EIF4G3 -331 893 4056 1034
FBXW11 -1449 8406 480 -1506
FLNB -2802 3880 2494 675
FLT3LG -2752 4449 -4476 6675
FOS -4562 4067 -1568 5645
FOXO1 -3602 816 -4632 3034
FOXO3 -3051 7309 2545 5022
FYN -2118 2799 -2956 2793
GAB2 -2692 347 3912 2390
GATA3 -395 8146 -4535 6272
GBP3 2699 7680 -3061 89
GRAP2 -2746 6230 -2761 3631
GRB10 561 190 4532 3328
GRB2 29 5972 4230 6239
GSDMD -2417 4172 1671 -91
GSTO1 347 7221 3900 3633
HERC5 4477 1222 -3630 -1037
HIF1A 1346 4099 2872 2448
HLA-A -4080 2266 -2368 -1093
HLA-B -821 510 896 -730
HLA-C 51 6767 1218 4448
HLA-E -950 3730 -1002 5634
HLA-F -3752 -24 -904 2974
HLA-H -4350 7821 -546 4988
HMGB1 1943 2521 -3489 3222
HNRNPA2B1 1271 2586 2367 2721
HNRNPF -3188 3524 -532 5855
HRAS -3453 1483 -1282 -823
HSP90AA1 3100 4857 -2176 6208
HSP90B1 4301 7702 -1893 2127
HSPA9 -243 5862 -4493 6549
ICAM1 -1757 6181 1880 2036
IFI30 2632 3541 4450 -1602
IFI35 3572 205 3006 1292
IFI6 3862 913 967 5535
IFIT1 4407 25 -3881 312
IFIT2 4291 -226 -3900 1477
IFIT3 4438 7094 -2788 6159
IFIT5 4463 7233 -4089 3745
IFITM1 1081 813 -1754 6983
IFNAR1 2671 6039 3008 1219
IFNAR2 -1339 1943 3116 1115
IFNGR1 3407 4319 3984 4124
IFNGR2 2871 6499 4530 4230
IKBKB -1861 958 1970 -912
IL10RA -2658 3506 605 5516
IL10RB 2492 1088 4296 -1075
IL12A 1447 2118 -2780 -1315
IL12RB1 -2291 -670 -1696 6630
IL12RB2 -4567 1065 -4043 -1859
IL15 1769 6831 1135 3611
IL15RA 3307 3533 2179 -1086
IL16 -3248 4110 -2267 5457
IL17C -2577 -487 3055 -1128
IL17RA 388 5913 4322 130
IL17RC -3722 7073 -539 1939
IL18BP 1389 -326 316 -1638
IL18R1 -2304 7423 850 6742
IL19 2005 -683 2850 7263
IL1RAP 2063 39 2084 -1120
IL21R -2031 2004 -3090 2722
IL23A 1948 -668 -4551 7076
IL27RA 295 4390 2711 6657
IL2RA 1014 432 -3039 6866
IL2RB -4721 5850 -4587 7234
IL32 616 212 -4349 7265
IL4R -494 -410 3746 1274
IL6R -583 6529 1258 5065
IL6ST 3221 3452 -1202 1708
INPP5D -3830 1160 2964 55
INPPL1 -2826 7266 4370 588
IP6K2 1553 7287 744 799
IRAK2 -3547 7809 -2980 4685
IRAK3 1420 2776 4357 666
IRF1 302 5434 -2536 5830
IRF2 3372 5303 2864 2365
IRF3 -2649 2791 -1301 4240
IRF4 2179 4585 -3146 5939
IRF5 -223 8174 2710 -1649
IRF7 2494 6595 3230 3556
IRF9 4132 5108 884 4774
IRS1 -4535 4409 -2997 4307
IRS2 -4076 5285 3498 6150
ISG15 3651 -537 -3046 6539
ISG20 -143 -116 -2935 7058
ITGB2 -4211 745 4253 6424
JAK1 -3630 6963 -3720 -283
JAK2 4309 6228 1486 6487
JUN -3724 2763 -598 1283
JUNB -4339 4464 541 5017
KPNA1 2982 6152 -1803 4422
KPNA2 2320 838 -1587 4420
KPNA3 3326 1397 -1791 4399
KPNA4 3677 8123 -297 4999
KPNA5 3718 1682 -3426 1847
KPNB1 2659 5901 -47 1140
KRAS 4442 4004 1217 3139
LCK -1825 2493 -4488 7243
LCP1 1687 4158 3798 4311
LGALS9 3366 3238 4298 -1460
LMNB1 3711 4088 4311 1051
LTA 2971 -622 -4104 7253
LTB -2128 4959 -4443 5584
MAP2K1 -1421 -148 3921 1533
MAP2K3 -2498 38 3714 2411
MAP2K4 1784 3155 1767 4763
MAP2K6 3151 2164 3939 4791
MAP2K7 -4193 2092 431 1764
MAP3K14 -2001 1381 -3221 4220
MAP3K3 -3332 2306 4125 3121
MAP3K7 2692 3839 1057 -147
MAP3K8 826 6359 4551 3266
MAPK1 -745 2758 4197 6097
MAPK14 1563 2227 4024 2465
MAPK3 -4620 -475 3649 1978
MAPK7 -2209 3007 3966 -244
MAPK8 -1037 6156 -3737 4553
MAPK9 -260 1152 -2605 157
MAPKAPK2 -3939 1416 2421 3265
MAPKAPK3 -1142 58 4580 2896
MEF2A 2271 7441 3276 3013
MIF -3715 2437 -3047 3355
MT2A 493 3765 33 1186
MTAP 2432 8029 -2882 2271
MUC1 -1022 6782 2987 6713
MX1 4155 1144 -2305 -1015
MX2 4270 -240 4101 1798
MYD88 1536 2750 4540 1945
NDC1 -28 -272 -4667 6480
NEDD4 2622 6200 3146 -1104
NFKB2 -128 2515 499 5250
NFKBIA -1959 3670 1551 6812
NFKBIB -4043 4651 2779 5572
NKIRAS1 -1254 4201 -3568 348
NKIRAS2 -2892 2008 4410 -1130
NOD1 702 2037 268 -321
NOD2 948 2355 4498 6608
NUP107 2943 1017 -4115 6299
NUP133 2030 1473 -2474 935
NUP153 1372 7264 -1870 4343
NUP155 1163 5083 -3460 3043
NUP160 1232 5781 -4066 1293
NUP188 -2474 591 -3287 2922
NUP205 1308 370 -3162 1670
NUP210 -4099 775 -1841 690
NUP214 779 7322 3866 4368
NUP35 3287 7567 -4566 -557
NUP37 1488 500 -594 3398
NUP43 3972 139 -3557 6344
NUP50 2599 5772 -517 6704
NUP54 4432 6517 -2306 831
NUP62 -1277 2703 156 4608
NUP85 2428 5395 -713 4517
NUP88 1692 6430 -4454 7082
NUP93 1140 7850 -1307 2006
NUP98 808 1649 64 -747
OAS1 4069 -193 1675 -1505
OAS2 4422 3120 -3241 6616
OAS3 3858 5403 -3256 616
OASL 4406 6399 3095 5927
OSM -4108 1297 161 1355
P4HB -3022 6808 3555 5716
PAK2 3060 2498 2198 283
PDCD4 3138 54 -4445 4219
PDE12 3461 -499 -1337 6081
PELI1 829 1534 725 1867
PELI2 -80 8419 1276 7033
PELI3 -4660 3884 4288 -1121
PIAS1 4489 7666 1762 2845
PIK3CA 2884 3277 -475 1470
PIK3CD -4035 151 2426 6107
PIK3R1 -2132 5137 -4392 6991
PIK3R2 -2279 5345 2344 3831
PIK3R3 2060 3520 1094 3645
PIM1 -708 2982 1290 1390
PIN1 -4611 3766 76 4014
PITPNA 512 1692 3198 3616
PLCG1 -749 5789 -3949 958
PML 1705 1158 976 4574
POM121 -4007 5147 -934 4680
POM121C -4243 5643 -2686 2061
POU2F1 3493 5425 2773 3909
PPIA -239 5602 -1924 4554
PPM1B 3124 -194 1490 -144
PPP2CA 2133 7688 1877 2598
PPP2CB 3173 15 2037 2771
PPP2R1B 1368 607 -1191 6169
PPP2R5D -1009 5720 986 3470
PRKACA -1378 3969 4529 890
PRKCD 301 8167 4500 6358
PRTN3 -4653 8354 -2832 5619
PSMA1 2917 5206 1363 4758
PSMA2 1509 4929 -836 5163
PSMA3 4416 1432 -1823 3586
PSMA5 3047 4175 -2828 3319
PSMA6 3897 6144 1661 6676
PSMA7 -246 5863 3266 6901
PSMB1 -371 2981 -803 5409
PSMB10 -3433 689 -161 6388
PSMB2 835 -501 1803 1518
PSMB3 23 780 3778 4305
PSMB5 -2694 183 3229 269
PSMB6 -3103 5638 3472 5817
PSMB7 -2378 1587 2955 4198
PSMB8 949 1746 2054 5155
PSMB9 -217 3058 -3454 4468
PSMC1 928 2242 2194 1413
PSMC3 -2624 4680 847 736
PSMC4 -1230 1188 537 3431
PSMC5 -1694 2039 -2600 5094
PSMC6 4108 118 1373 2356
PSMD1 2911 5546 2375 56
PSMD11 4009 2032 2637 3521
PSMD12 4511 5250 2167 3681
PSMD13 -998 7807 1482 561
PSMD14 3360 3896 85 6314
PSMD2 -3334 6719 2097 3610
PSMD3 -4637 3063 1629 5579
PSMD4 -1530 1685 3940 5313
PSMD6 1854 3171 3275 2336
PSMD7 3595 864 596 2079
PSMD8 -2435 7747 2069 4665
PSMD9 -3510 -186 3384 3375
PSME1 1353 7210 -2849 1614
PSME2 3304 7208 -1478 778
PSME3 802 6539 2470 5231
PSME4 3349 7885 -461 5908
PSMF1 -1946 2260 416 7179
PTK2B -3952 4106 4499 4528
PTPN1 -1209 -294 3707 699
PTPN11 -256 3762 1122 5061
PTPN12 608 -601 1634 -982
PTPN13 -4440 8337 -2577 6848
PTPN18 -1734 887 4371 3436
PTPN2 2787 3163 4008 181
PTPN23 -1373 3838 2730 5426
PTPN4 -398 1836 -4481 784
PTPN6 -1174 2534 4395 6540
PTPN7 1233 1319 -1494 2323
PTPN9 -858 2987 4448 6094
PTPRJ -2062 6860 3552 7167
RAE1 2280 705 1931 2634
RALA 2197 1756 -3637 2302
RANBP2 2136 4418 -1280 5164
RAP1B 2749 6134 2033 5966
RAPGEF1 -3506 6250 1511 6443
RBX1 1451 6206 1453 5881
RELA -4376 5729 -1050 4332
RELB -1928 4179 2626 577
RNASEL 1776 3068 3937 3400
RNF7 -414 1274 2999 5839
RORA -1351 7045 -4542 6931
RPLP0 -4068 5078 -4060 4850
RPS27A -3731 2481 -4078 2589
RPS6KA1 -2393 6272 4241 -1857
RPS6KA2 -3185 6436 -715 2117
RPS6KA5 4173 7351 -3252 1991
S1PR1 -19 -331 -3578 6789
SAMHD1 3503 7333 3768 6189
SEC13 -1298 7330 2552 6209
SEH1L 3665 6621 -4109 3577
SH2B1 -1908 4860 -1276 1436
SH2B3 -2452 3414 3520 3851
SHC1 47 7294 2954 3205
SIGIRR -3514 8336 -2448 6805
SKP1 3454 3180 -2543 2680
SLA 4046 366 3680 6984
SLA2 -2415 6510 -4294 4870
SMAD3 -571 5305 -2989 -363
SMARCA4 -3629 2881 2224 6790
SNRPA1 1550 6067 -2069 1539
SOCS1 3263 5646 2492 4130
SOCS2 1601 6635 -1294 6477
SOCS3 -4725 693 4095 6490
SOCS5 -415 3620 -1558 466
SOD1 90 6446 -2571 1838
SOD2 177 6323 3199 6132
SOS1 3053 3267 -1345 -1984
SOS2 2591 87 3354 3699
SP100 4417 3022 3388 2285
SQSTM1 -3391 1301 -1278 658
STAT1 3698 949 -4441 4969
STAT2 3596 3473 1612 5931
STAT3 1049 7062 3091 4994
STAT4 1560 3811 -4377 4202
STAT5A -3150 -563 3416 -1543
STAT5B -2600 7765 1731 1495
STAT6 -2092 3383 4260 3854
STX1A -1885 1038 248 4173
STX3 371 5386 3443 2712
STX4 -1332 4490 3053 1609
STXBP2 -623 7943 4521 -155
SUMO1 3870 4413 1420 3368
SYK 927 3885 3853 431
TAB2 1280 -849 -1462 6399
TALDO1 -497 2943 4000 4421
TBK1 4522 6493 2094 599
TCP1 2342 2222 -2270 -448
TEC 1638 2871 4185 170
TGFB1 -3576 4335 -268 3769
TNF 3685 -672 -2015 -526
TNFRSF12A -3458 8175 2338 681
TNFRSF1A -757 1590 4369 -1546
TNFRSF1B -1307 1250 4281 6868
TNFRSF25 -3232 307 -4613 6987
TNFSF13 -1161 5409 4326 -1362
TNFSF13B 3729 1281 2715 -384
TNFSF14 751 2869 1178 7175
TNFSF9 -267 -538 2679 447
TNIP2 -2442 793 2575 287
TOLLIP -3659 1231 2911 664
TP53 -1807 1985 -4011 2709
TPR 1846 5115 -1721 4615
TRAF2 40 5279 -2998 5763
TRAF3 -3088 3505 -2224 7206
TRAF6 878 6544 -562 -71
TRIM14 140 1699 905 1982
TRIM2 -2871 2374 -3794 646
TRIM21 3284 -41 2994 -1671
TRIM22 4119 1099 419 2278
TRIM25 1951 6633 4223 446
TRIM26 -364 4586 2045 3540
TRIM35 -2740 4825 -4337 1556
TRIM38 4208 5505 2662 4882
TRIM45 448 5168 -3327 -1040
TRIM46 -221 3178 -3184 3136
TRIM5 4187 5670 1797 395
TRIM62 -1441 6587 -654 3890
TRIM68 -1855 -333 -3500 -539
TRIM8 -2686 4622 4202 6373
TXLNA 937 8130 839 7005
TYK2 -2482 1902 4365 4072
UBA3 4072 719 3656 4052
UBA52 -3208 4386 -596 -69
UBA7 -1691 3029 575 -1589
UBB -2084 561 -996 5058
UBC -1739 2624 1876 3220
UBE2D1 1930 4687 3454 2741
UBE2D2 -56 4255 -1159 2134
UBE2D3 3202 2444 2392 3005
UBE2E1 3227 3136 113 2408
UBE2L6 2934 760 -3002 1295
UBE2M -4705 5150 1539 2052
UBE2N 3397 6741 -1303 4833
UBE2V1 2034 4568 -1420 2792
USP18 4340 -385 -2548 -1012
VAMP2 258 533 -3262 -1237
VAV1 -2612 6923 3874 5832
VEGFA -3059 827 1628 87
VIM -1688 3605 4349 3780
VRK3 1695 5188 2478 2903
XAF1 4429 4678 -1243 -1462
YES1 677 -619 -2471 5197
YWHAZ 3562 2726 -278 4293
ZEB1 325 6286 -3849 5935





Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation
metric value
setSize 133
pMANOVA 1.35e-07
p.adjustMANOVA 1.35e-07
s.dist 0.307
s.t0_crp_RNA -0.11
s.t0_crp_meth 0.0535
s.pod_crp_RNA 0.273
s.pod_crp_meth 0.068
p.t0_crp_RNA 0.0296
p.t0_crp_meth 0.289
p.pod_crp_RNA 5.81e-08
p.pod_crp_meth 0.178



Warning in xtfrm.data.frame(x): cannot xtfrm data frames


Top 20 genes
Gene pod_crp_RNA t0_crp_RNA
GNA15 4385 -3902
MAPK3 3649 -4620
FERMT3 4150 -3314
CD63 4520 -2910
TLN1 3346 -3596
CFL1 3672 -3249
CSK 3950 -2994
TOR4A 4200 -2784
ACTN4 3811 -3020
PIK3R5 2607 -4359
QSOX1 4519 -2300
AKT1 2297 -4471
VAV1 3874 -2612
PRKCB 2655 -3677
ARRB2 4280 -2258
GNB2 3855 -2502
CYB5R1 3974 -2380
WDR1 3245 -2728
VAV3 2141 -4054
ARRB1 2221 -3738

Click HERE to show all gene set members

All member genes
t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
A1BG -4720 7280 525 567
AAMP -4607 1163 -1372 7118
ABCC4 -891 3822 -1890 2355
ABHD12 -4206 7116 -1418 5948
ABHD6 1803 6924 1640 2533
ACTN1 -3263 -14 2475 7237
ACTN4 -3020 1010 3811 1596
AKT1 -4471 4213 2297 1109
ALDOA -1859 643 4238 5366
ANXA5 2092 2696 4114 2872
APBB1IP 2235 5817 3712 3821
APLP2 350 108 4306 -964
APP -1029 7569 1303 6621
ARRB1 -3738 3174 2221 -1276
ARRB2 -2258 4618 4280 2913
BRPF3 -2382 4755 -1904 3308
CALM1 1287 3980 -2201 4501
CALU 3161 2230 3100 1962
CAP1 497 5559 3138 2034
CD63 -2910 7177 4520 5433
CDC37L1 4179 2978 -3593 519
CDC42 3320 7040 2741 856
CFL1 -3249 4059 3672 1646
CHID1 -4126 6799 721 1830
CRK 3068 5936 3523 6596
CSK -2994 1998 3950 4889
CYB5R1 -2380 6424 3974 5879
DAGLB 515 6040 4396 -302
DGKA 879 30 -3554 7031
DGKD -4664 1873 1631 4805
DGKE 1054 3611 -3235 6505
DGKG 390 -684 3223 4392
DGKH 2981 4503 -1275 4127
DGKQ -2527 358 -1145 3114
DGKZ -4624 3190 -1348 -1313
ENDOD1 -1572 755 -2323 -639
FAM3C 1385 690 -4096 32
FERMT3 -3314 6369 4150 5111
FYN -2118 2799 -2956 2793
GNA12 -2122 7455 -1739 4302
GNA13 362 3946 -288 3330
GNA15 -3902 7100 4385 -1922
GNAI2 -1673 5401 4018 3218
GNAI3 2539 700 1964 2359
GNAQ 2758 3816 2814 -1830
GNB1 -2153 -389 3695 2799
GNB2 -2502 6029 3855 1879
GNB4 3398 8143 2201 1335
GNB5 -441 5776 -2946 6254
GNG2 -335 4273 -1270 6498
GNG3 3186 8362 2852 7139
GNG4 1800 6983 1913 6854
GNG5 2604 3736 4182 6510
GNG7 -1065 -471 -3131 -499
GNGT2 -1574 -71 766 7117
GRB2 29 5972 4230 6239
GTPBP2 -396 -561 4424 4514
HABP4 -1015 2368 -4652 3365
ITPR1 -1901 6612 -1565 1789
ITPR2 1162 4456 2298 -44
ITPR3 -748 2875 -2503 2189
LCK -1825 2493 -4488 7243
LCP2 2815 -273 200 -428
MANF 374 6933 -1581 6554
MAPK1 -745 2758 4197 6097
MAPK14 1563 2227 4024 2465
MAPK3 -4620 -475 3649 1978
NHLRC2 2809 3721 -2043 -59
OLA1 2885 4765 -2213 6471
P2RY1 37 8330 4557 3720
PCYOX1L 821 5272 -747 2972
PDPK1 -3330 144 2187 346
PFN1 -2208 2486 3213 3814
PHACTR2 -1977 3667 -543 -1837
PIK3CA 2884 3277 -475 1470
PIK3CG 153 2554 2373 2051
PIK3R1 -2132 5137 -4392 6991
PIK3R2 -2279 5345 2344 3831
PIK3R3 2060 3520 1094 3645
PIK3R5 -4359 1796 2607 4482
PLCG2 -1458 6158 3982 2803
PLEK -685 -784 1598 -567
PPIA -239 5602 -1924 4554
PRKCA -2583 7972 -2473 6892
PRKCB -3677 4193 2655 4963
PRKCD 301 8167 4500 6358
PRKCE -1194 7105 3475 -1183
PRKCH -3115 5155 -4661 2578
PRKCQ -1185 3922 -4577 4207
PRKCZ -3370 -228 -2888 -1374
PSAP 506 1283 3823 628
PTK2 -814 2487 -1377 -475
PTPN1 -1209 -294 3707 699
PTPN11 -256 3762 1122 5061
PTPN6 -1174 2534 4395 6540
QSOX1 -2300 6788 4519 5725
RAC1 3574 7484 4225 5539
RAC2 -3760 6815 1945 4576
RAF1 537 4277 3739 6571
RAP1A 4512 2607 2624 6567
RAP1B 2749 6134 2033 5966
RASGRP1 500 3237 -4511 5886
RASGRP2 -3881 4893 -1986 -413
RHOA 2796 1879 3280 4033
RHOB 1659 4733 2234 2346
RHOG -703 3967 4093 3664
SCCPDH 3184 3621 3640 1126
SHC1 47 7294 2954 3205
SOD1 90 6446 -2571 1838
SOS1 3053 3267 -1345 -1984
SRC -1769 -92 -2399 -1474
SRGN 2091 7302 3446 1395
STX4 -1332 4490 3053 1609
STXBP2 -623 7943 4521 -155
STXBP3 4513 5653 2586 199
SYK 927 3885 3853 431
TAGLN2 -3607 3294 53 1679
TEX264 -3590 4940 -950 5265
TGFB1 -3576 4335 -268 3769
TGFB2 2182 2587 2355 -1897
TGFB3 -3572 7609 -2151 -978
TLN1 -3596 2096 3346 -983
TMX3 3601 -352 -1427 -543
TOR4A -2784 8082 4200 -1618
TUBA4A -119 7127 1535 4105
VAV1 -2612 6923 3874 5832
VAV2 -832 7700 2796 4133
VAV3 -4054 8267 2141 -685
VCL -1153 1830 476 3614
VEGFA -3059 827 1628 87
VTI1B -89 4245 2825 3178
WDR1 -2728 2479 3245 7034
YWHAZ 3562 2726 -278 4293





Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.1.0 (2021-05-18)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.1    GGally_2.1.1     ggplot2_3.3.3    reshape2_1.4.4  
##  [5] beeswarm_0.3.1   gtools_3.8.2     tibble_3.1.2     dplyr_1.0.6     
##  [9] echarts4r_0.4.0  kableExtra_1.3.4 mitch_1.4.0      gplots_3.1.1    
## 
## loaded via a namespace (and not attached):
##  [1] httr_1.4.2         sass_0.4.0         jsonlite_1.7.2     viridisLite_0.4.0 
##  [5] bslib_0.2.5.1      shiny_1.6.0        assertthat_0.2.1   highr_0.9         
##  [9] progress_1.2.2     yaml_2.2.1         pillar_1.6.1       glue_1.4.2        
## [13] digest_0.6.27      RColorBrewer_1.1-2 promises_1.2.0.1   rvest_1.0.0       
## [17] colorspace_2.0-1   htmltools_0.5.1.1  httpuv_1.6.1       plyr_1.8.6        
## [21] pkgconfig_2.0.3    purrr_0.3.4        xtable_1.8-4       scales_1.1.1      
## [25] webshot_0.5.2      svglite_2.0.0      later_1.2.0        generics_0.1.0    
## [29] farver_2.1.0       ellipsis_0.3.2     withr_2.4.2        magrittr_2.0.1    
## [33] crayon_1.4.1       mime_0.10          evaluate_0.14      fansi_0.5.0       
## [37] MASS_7.3-54        xml2_1.3.2         prettyunits_1.1.1  tools_4.1.0       
## [41] hms_1.1.0          lifecycle_1.0.0    stringr_1.4.0      munsell_0.5.0     
## [45] compiler_4.1.0     jquerylib_0.1.4    caTools_1.18.2     systemfonts_1.0.2 
## [49] rlang_0.4.11       grid_4.1.0         rstudioapi_0.13    htmlwidgets_1.5.3 
## [53] bitops_1.0-7       labeling_0.4.2     rmarkdown_2.8      gtable_0.3.0      
## [57] DBI_1.1.1          reshape_0.8.8      R6_2.5.0           gridExtra_2.3     
## [61] knitr_1.33         fastmap_1.1.0      utf8_1.2.1         rprojroot_2.0.2   
## [65] KernSmooth_2.23-20 desc_1.3.0         stringi_1.6.2      parallel_4.1.0    
## [69] Rcpp_1.0.6         vctrs_0.3.8        tidyselect_1.1.1   xfun_0.23

END of report