Mitch Report

date generated: 2021-04-27

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##              RNA        meth
## A1BG   2.6192564 -0.45188238
## AAAS  -2.6372410  0.06143186
## AACS   0.1010134  0.13997068
## AAGAB  1.0702585 -0.59522248
## AAK1  -3.0047762 -0.32725606
## AAMDC  2.2859640 -0.21261544

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	9311
duplicated_genes_present	0
num_profile_genes_in_sets	5601
num_profile_genes_not_in_sets	3710
profile_pearson_correl	-0.10543
profile_spearman_correl	-0.08313

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2484
num_genesets_excluded	1322
num_genesets_included	1162

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 420

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.RNA	s.meth	p.RNA	p.meth
Neutrophil degranulation	305	5.80e-54	6.73e-51	0.525	0.5230	-4.99e-02	2.98e-55	1.38e-01
Innate Immune System	616	1.27e-46	7.40e-44	0.348	0.3480	-1.37e-02	8.51e-48	5.70e-01
Immune System	1142	2.01e-30	7.78e-28	0.208	0.2020	4.93e-02	1.16e-28	6.86e-03
Vesicle-mediated transport	442	1.93e-20	5.17e-18	0.267	0.2670	3.47e-05	2.19e-21	9.99e-01
Membrane Trafficking	436	2.23e-20	5.17e-18	0.268	0.2680	-1.37e-04	2.52e-21	9.96e-01
Signal Transduction	1292	1.72e-18	3.34e-16	0.154	0.1510	2.68e-02	2.13e-18	1.22e-01
Signaling by Receptor Tyrosine Kinases	284	6.36e-13	1.06e-10	0.256	0.2530	4.17e-02	3.55e-13	2.30e-01
Disease	930	7.12e-12	1.03e-09	0.138	0.1280	5.20e-02	1.27e-10	9.12e-03
Signaling by Interleukins	263	1.38e-11	1.79e-09	0.253	0.2530	1.51e-02	2.56e-12	6.77e-01
Metabolism of proteins	1263	1.63e-11	1.81e-09	0.118	0.0990	6.45e-02	1.41e-08	2.24e-04
rRNA processing	159	1.71e-11	1.81e-09	0.336	-0.2890	1.71e-01	3.63e-10	2.07e-04
Metabolism	1216	3.16e-11	3.06e-09	0.124	0.1230	-1.48e-02	3.67e-12	4.04e-01
Major pathway of rRNA processing in the nucleolus and cytosol	147	5.25e-11	4.69e-09	0.342	-0.2830	1.93e-01	3.83e-09	5.68e-05
Post-translational protein modification	890	7.82e-11	6.49e-09	0.134	0.1210	5.81e-02	2.95e-09	4.31e-03
rRNA processing in the nucleus and cytosol	154	1.28e-10	9.89e-09	0.328	-0.2740	1.80e-01	4.78e-09	1.29e-04
Diseases of signal transduction by growth factor receptors and second messengers	265	1.36e-10	9.89e-09	0.240	0.2400	1.41e-02	2.50e-11	6.95e-01
Gene expression (Transcription)	1006	1.81e-10	1.24e-08	0.128	-0.1280	-7.41e-03	3.31e-11	7.01e-01
Hemostasis	304	1.93e-10	1.25e-08	0.224	0.2240	1.40e-03	2.70e-11	9.67e-01
Generic Transcription Pathway	803	3.15e-10	1.92e-08	0.137	-0.1300	-4.23e-02	9.23e-10	4.73e-02
Transport of small molecules	342	1.21e-09	7.04e-08	0.205	0.2040	-2.04e-02	1.48e-10	5.22e-01
Infectious disease	530	4.84e-09	2.68e-07	0.153	0.1160	9.96e-02	6.88e-06	1.15e-04
Programmed Cell Death	153	1.12e-08	5.78e-07	0.281	0.2790	3.26e-02	2.99e-09	4.89e-01
Cellular response to chemical stress	116	1.15e-08	5.78e-07	0.328	0.3260	-3.30e-02	1.48e-09	5.41e-01
Platelet activation, signaling and aggregation	133	1.35e-08	6.55e-07	0.297	0.2910	6.25e-02	8.09e-09	2.15e-01
Cellular responses to external stimuli	457	2.73e-08	1.27e-06	0.157	0.1210	9.95e-02	1.27e-05	3.28e-04
EPH-Ephrin signaling	55	3.52e-08	1.57e-06	0.465	0.4510	-1.12e-01	7.45e-09	1.53e-01
Asparagine N-linked glycosylation	222	3.90e-08	1.68e-06	0.227	0.2260	1.72e-02	8.02e-09	6.61e-01
RNA Polymerase II Transcription	895	4.61e-08	1.91e-06	0.115	-0.1100	-3.35e-02	6.09e-08	9.91e-02
Metabolism of RNA	535	6.68e-08	2.68e-06	0.153	-0.0918	1.23e-01	3.55e-04	1.72e-06
Metabolism of lipids	427	7.26e-08	2.81e-06	0.164	0.1640	-9.59e-03	9.91e-09	7.37e-01
Influenza Viral RNA Transcription and Replication	110	7.60e-08	2.85e-06	0.330	-0.2240	2.42e-01	5.08e-05	1.27e-05
Cellular responses to stress	452	8.05e-08	2.92e-06	0.152	0.1160	9.86e-02	3.01e-05	3.97e-04
Signaling by NOTCH	130	1.41e-07	4.96e-06	0.286	0.2860	-5.81e-03	2.07e-08	9.09e-01
Signaling by NTRKs	90	1.75e-07	5.99e-06	0.334	0.3250	7.62e-02	1.07e-07	2.13e-01
Interleukin-1 signaling	78	2.35e-07	7.79e-06	0.360	0.3600	1.53e-02	4.21e-08	8.15e-01
Influenza Infection	128	2.54e-07	8.20e-06	0.294	-0.1840	2.30e-01	3.40e-04	7.89e-06
ER to Golgi Anterograde Transport	105	2.66e-07	8.36e-06	0.308	0.3070	2.49e-02	5.65e-08	6.61e-01
tRNA processing	93	3.00e-07	9.18e-06	0.337	-0.3190	1.08e-01	1.11e-07	7.18e-02
Regulation of actin dynamics for phagocytic cup formation	45	5.57e-07	1.66e-05	0.462	0.4620	-1.20e-02	8.41e-08	8.89e-01
Response to elevated platelet cytosolic Ca2+	53	6.35e-07	1.84e-05	0.423	0.4230	6.61e-03	1.06e-07	9.34e-01
Toll-like Receptor Cascades	108	7.51e-07	2.13e-05	0.295	0.2950	2.49e-03	1.23e-07	9.64e-01
Leishmania infection	110	9.26e-07	2.56e-05	0.295	0.2900	-5.40e-02	1.58e-07	3.30e-01
Peptide chain elongation	67	9.52e-07	2.57e-05	0.387	-0.2450	3.00e-01	5.31e-04	2.26e-05
Eukaryotic Translation Elongation	70	1.15e-06	3.02e-05	0.377	-0.2390	2.91e-01	5.70e-04	2.60e-05
Apoptosis	132	1.27e-06	3.04e-05	0.259	0.2550	4.60e-02	4.70e-07	3.64e-01
Developmental Biology	450	1.30e-06	3.04e-05	0.145	0.1450	-5.42e-03	1.98e-07	8.46e-01
Toll Like Receptor 4 (TLR4) Cascade	93	1.31e-06	3.04e-05	0.310	0.3090	2.24e-02	2.72e-07	7.09e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	71	1.34e-06	3.04e-05	0.357	0.3570	-7.59e-03	2.09e-07	9.12e-01
Toll Like Receptor 2 (TLR2) Cascade	71	1.34e-06	3.04e-05	0.357	0.3570	-7.59e-03	2.09e-07	9.12e-01
Toll Like Receptor TLR1:TLR2 Cascade	71	1.34e-06	3.04e-05	0.357	0.3570	-7.59e-03	2.09e-07	9.12e-01

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.RNA	s.meth	p.RNA	p.meth
Neutrophil degranulation	305	5.80e-54	6.73e-51	0.52500	0.523000	-4.99e-02	2.98e-55	1.38e-01
Innate Immune System	616	1.27e-46	7.40e-44	0.34800	0.348000	-1.37e-02	8.51e-48	5.70e-01
Immune System	1142	2.01e-30	7.78e-28	0.20800	0.202000	4.93e-02	1.16e-28	6.86e-03
Vesicle-mediated transport	442	1.93e-20	5.17e-18	0.26700	0.267000	3.47e-05	2.19e-21	9.99e-01
Membrane Trafficking	436	2.23e-20	5.17e-18	0.26800	0.268000	-1.37e-04	2.52e-21	9.96e-01
Signal Transduction	1292	1.72e-18	3.34e-16	0.15400	0.151000	2.68e-02	2.13e-18	1.22e-01
Signaling by Receptor Tyrosine Kinases	284	6.36e-13	1.06e-10	0.25600	0.253000	4.17e-02	3.55e-13	2.30e-01
Disease	930	7.12e-12	1.03e-09	0.13800	0.128000	5.20e-02	1.27e-10	9.12e-03
Signaling by Interleukins	263	1.38e-11	1.79e-09	0.25300	0.253000	1.51e-02	2.56e-12	6.77e-01
Metabolism of proteins	1263	1.63e-11	1.81e-09	0.11800	0.099000	6.45e-02	1.41e-08	2.24e-04
rRNA processing	159	1.71e-11	1.81e-09	0.33600	-0.289000	1.71e-01	3.63e-10	2.07e-04
Metabolism	1216	3.16e-11	3.06e-09	0.12400	0.123000	-1.48e-02	3.67e-12	4.04e-01
Major pathway of rRNA processing in the nucleolus and cytosol	147	5.25e-11	4.69e-09	0.34200	-0.283000	1.93e-01	3.83e-09	5.68e-05
Post-translational protein modification	890	7.82e-11	6.49e-09	0.13400	0.121000	5.81e-02	2.95e-09	4.31e-03
rRNA processing in the nucleus and cytosol	154	1.28e-10	9.89e-09	0.32800	-0.274000	1.80e-01	4.78e-09	1.29e-04
Diseases of signal transduction by growth factor receptors and second messengers	265	1.36e-10	9.89e-09	0.24000	0.240000	1.41e-02	2.50e-11	6.95e-01
Gene expression (Transcription)	1006	1.81e-10	1.24e-08	0.12800	-0.128000	-7.41e-03	3.31e-11	7.01e-01
Hemostasis	304	1.93e-10	1.25e-08	0.22400	0.224000	1.40e-03	2.70e-11	9.67e-01
Generic Transcription Pathway	803	3.15e-10	1.92e-08	0.13700	-0.130000	-4.23e-02	9.23e-10	4.73e-02
Transport of small molecules	342	1.21e-09	7.04e-08	0.20500	0.204000	-2.04e-02	1.48e-10	5.22e-01
Infectious disease	530	4.84e-09	2.68e-07	0.15300	0.116000	9.96e-02	6.88e-06	1.15e-04
Programmed Cell Death	153	1.12e-08	5.78e-07	0.28100	0.279000	3.26e-02	2.99e-09	4.89e-01
Cellular response to chemical stress	116	1.15e-08	5.78e-07	0.32800	0.326000	-3.30e-02	1.48e-09	5.41e-01
Platelet activation, signaling and aggregation	133	1.35e-08	6.55e-07	0.29700	0.291000	6.25e-02	8.09e-09	2.15e-01
Cellular responses to external stimuli	457	2.73e-08	1.27e-06	0.15700	0.121000	9.95e-02	1.27e-05	3.28e-04
EPH-Ephrin signaling	55	3.52e-08	1.57e-06	0.46500	0.451000	-1.12e-01	7.45e-09	1.53e-01
Asparagine N-linked glycosylation	222	3.90e-08	1.68e-06	0.22700	0.226000	1.72e-02	8.02e-09	6.61e-01
RNA Polymerase II Transcription	895	4.61e-08	1.91e-06	0.11500	-0.110000	-3.35e-02	6.09e-08	9.91e-02
Metabolism of RNA	535	6.68e-08	2.68e-06	0.15300	-0.091800	1.23e-01	3.55e-04	1.72e-06
Metabolism of lipids	427	7.26e-08	2.81e-06	0.16400	0.164000	-9.59e-03	9.91e-09	7.37e-01
Influenza Viral RNA Transcription and Replication	110	7.60e-08	2.85e-06	0.33000	-0.224000	2.42e-01	5.08e-05	1.27e-05
Cellular responses to stress	452	8.05e-08	2.92e-06	0.15200	0.116000	9.86e-02	3.01e-05	3.97e-04
Signaling by NOTCH	130	1.41e-07	4.96e-06	0.28600	0.286000	-5.81e-03	2.07e-08	9.09e-01
Signaling by NTRKs	90	1.75e-07	5.99e-06	0.33400	0.325000	7.62e-02	1.07e-07	2.13e-01
Interleukin-1 signaling	78	2.35e-07	7.79e-06	0.36000	0.360000	1.53e-02	4.21e-08	8.15e-01
Influenza Infection	128	2.54e-07	8.20e-06	0.29400	-0.184000	2.30e-01	3.40e-04	7.89e-06
ER to Golgi Anterograde Transport	105	2.66e-07	8.36e-06	0.30800	0.307000	2.49e-02	5.65e-08	6.61e-01
tRNA processing	93	3.00e-07	9.18e-06	0.33700	-0.319000	1.08e-01	1.11e-07	7.18e-02
Regulation of actin dynamics for phagocytic cup formation	45	5.57e-07	1.66e-05	0.46200	0.462000	-1.20e-02	8.41e-08	8.89e-01
Response to elevated platelet cytosolic Ca2+	53	6.35e-07	1.84e-05	0.42300	0.423000	6.61e-03	1.06e-07	9.34e-01
Toll-like Receptor Cascades	108	7.51e-07	2.13e-05	0.29500	0.295000	2.49e-03	1.23e-07	9.64e-01
Leishmania infection	110	9.26e-07	2.56e-05	0.29500	0.290000	-5.40e-02	1.58e-07	3.30e-01
Peptide chain elongation	67	9.52e-07	2.57e-05	0.38700	-0.245000	3.00e-01	5.31e-04	2.26e-05
Eukaryotic Translation Elongation	70	1.15e-06	3.02e-05	0.37700	-0.239000	2.91e-01	5.70e-04	2.60e-05
Apoptosis	132	1.27e-06	3.04e-05	0.25900	0.255000	4.60e-02	4.70e-07	3.64e-01
Developmental Biology	450	1.30e-06	3.04e-05	0.14500	0.145000	-5.42e-03	1.98e-07	8.46e-01
Toll Like Receptor 4 (TLR4) Cascade	93	1.31e-06	3.04e-05	0.31000	0.309000	2.24e-02	2.72e-07	7.09e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	71	1.34e-06	3.04e-05	0.35700	0.357000	-7.59e-03	2.09e-07	9.12e-01
Toll Like Receptor 2 (TLR2) Cascade	71	1.34e-06	3.04e-05	0.35700	0.357000	-7.59e-03	2.09e-07	9.12e-01
Toll Like Receptor TLR1:TLR2 Cascade	71	1.34e-06	3.04e-05	0.35700	0.357000	-7.59e-03	2.09e-07	9.12e-01
Toll Like Receptor TLR6:TLR2 Cascade	71	1.34e-06	3.04e-05	0.35700	0.357000	-7.59e-03	2.09e-07	9.12e-01
Platelet degranulation	49	1.70e-06	3.79e-05	0.42300	0.423000	1.82e-02	3.15e-07	8.26e-01
Clathrin-mediated endocytosis	90	1.87e-06	4.09e-05	0.31100	0.311000	1.85e-02	3.68e-07	7.63e-01
MHC class II antigen presentation	70	2.14e-06	4.58e-05	0.36100	0.346000	-1.02e-01	5.75e-07	1.42e-01
Interleukin-1 family signaling	98	2.17e-06	4.58e-05	0.30000	0.299000	-1.74e-02	3.29e-07	7.67e-01
Signaling by NTRK1 (TRKA)	82	2.26e-06	4.68e-05	0.32100	0.316000	5.45e-02	7.83e-07	3.95e-01
MAPK family signaling cascades	185	2.50e-06	5.11e-05	0.20900	0.177000	1.12e-01	3.69e-05	9.18e-03
Detoxification of Reactive Oxygen Species	23	2.57e-06	5.14e-05	0.61700	0.610000	-9.37e-02	4.16e-07	4.37e-01
PIP3 activates AKT signaling	181	2.77e-06	5.46e-05	0.21200	0.191000	9.05e-02	9.99e-06	3.68e-02
Transport to the Golgi and subsequent modification	127	3.03e-06	5.86e-05	0.25900	0.259000	5.22e-03	5.31e-07	9.19e-01
Eukaryotic Translation Termination	70	4.14e-06	7.78e-05	0.35800	-0.221000	2.82e-01	1.39e-03	4.73e-05
Formation of a pool of free 40S subunits	76	4.15e-06	7.78e-05	0.34300	-0.188000	2.87e-01	4.65e-03	1.59e-05
Selenocysteine synthesis	68	5.43e-06	9.64e-05	0.36000	-0.249000	2.60e-01	4.04e-04	2.11e-04
COPI-mediated anterograde transport	68	5.51e-06	9.64e-05	0.34200	0.340000	3.17e-02	1.26e-06	6.52e-01
MyD88 cascade initiated on plasma membrane	65	5.56e-06	9.64e-05	0.34800	0.345000	4.75e-02	1.56e-06	5.09e-01
Toll Like Receptor 10 (TLR10) Cascade	65	5.56e-06	9.64e-05	0.34800	0.345000	4.75e-02	1.56e-06	5.09e-01
Toll Like Receptor 5 (TLR5) Cascade	65	5.56e-06	9.64e-05	0.34800	0.345000	4.75e-02	1.56e-06	5.09e-01
Cytokine Signaling in Immune system	424	6.35e-06	1.08e-04	0.13500	0.113000	7.35e-02	8.15e-05	1.05e-02
Viral mRNA Translation	67	6.39e-06	1.08e-04	0.36000	-0.222000	2.83e-01	1.73e-03	6.29e-05
Golgi-to-ER retrograde transport	92	6.84e-06	1.13e-04	0.29200	0.291000	2.34e-02	1.49e-06	6.99e-01
Autophagy	104	6.89e-06	1.13e-04	0.27700	0.277000	-1.07e-02	1.11e-06	8.50e-01
RHO GTPases Activate WASPs and WAVEs	29	7.74e-06	1.25e-04	0.52100	0.521000	-3.09e-02	1.23e-06	7.73e-01
trans-Golgi Network Vesicle Budding	52	7.85e-06	1.25e-04	0.39800	0.377000	-1.25e-01	2.55e-06	1.18e-01
Adaptive Immune System	475	7.93e-06	1.25e-04	0.12700	0.106000	6.89e-02	9.42e-05	1.13e-02
Intra-Golgi and retrograde Golgi-to-ER traffic	155	8.34e-06	1.29e-04	0.22400	0.224000	1.06e-02	1.62e-06	8.21e-01
Activation of the pre-replicative complex	28	8.55e-06	1.30e-04	0.54600	-0.473000	2.72e-01	1.49e-05	1.27e-02
Activation of ATR in response to replication stress	34	8.62e-06	1.30e-04	0.49400	-0.440000	2.24e-01	8.98e-06	2.38e-02
Intracellular signaling by second messengers	206	8.73e-06	1.30e-04	0.19100	0.181000	6.16e-02	8.95e-06	1.30e-01
SRP-dependent cotranslational protein targeting to membrane	85	9.95e-06	1.46e-04	0.31000	-0.124000	2.84e-01	4.84e-02	6.09e-06
DNA strand elongation	27	1.12e-05	1.63e-04	0.54600	-0.499000	2.21e-01	7.14e-06	4.67e-02
MAP2K and MAPK activation	25	1.16e-05	1.67e-04	0.53500	0.505000	1.77e-01	1.24e-05	1.26e-01
Cellular response to hypoxia	60	1.30e-05	1.84e-04	0.35200	0.351000	1.77e-02	2.57e-06	8.13e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	66	1.35e-05	1.89e-04	0.33200	0.329000	4.83e-02	3.94e-06	4.98e-01
Signaling by WNT	174	1.44e-05	1.97e-04	0.20300	0.193000	6.25e-02	1.24e-05	1.57e-01
ROS and RNS production in phagocytes	23	1.44e-05	1.97e-04	0.57100	0.569000	-5.56e-02	2.35e-06	6.44e-01
RAB geranylgeranylation	39	1.46e-05	1.97e-04	0.42300	0.389000	1.66e-01	2.67e-05	7.28e-02
MAPK1/MAPK3 signaling	160	1.68e-05	2.25e-04	0.20700	0.171000	1.17e-01	1.98e-04	1.14e-02
FCGR3A-mediated phagocytosis	43	1.78e-05	2.30e-04	0.41200	0.412000	-1.40e-02	3.00e-06	8.74e-01
Leishmania phagocytosis	43	1.78e-05	2.30e-04	0.41200	0.412000	-1.40e-02	3.00e-06	8.74e-01
Parasite infection	43	1.78e-05	2.30e-04	0.41200	0.412000	-1.40e-02	3.00e-06	8.74e-01
MyD88 dependent cascade initiated on endosome	67	2.30e-05	2.91e-04	0.32100	0.315000	5.97e-02	8.28e-06	3.99e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	67	2.30e-05	2.91e-04	0.32100	0.315000	5.97e-02	8.28e-06	3.99e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	72	2.67e-05	3.33e-04	0.32600	-0.196000	2.60e-01	4.13e-03	1.40e-04
RAF/MAP kinase cascade	155	3.19e-05	3.91e-04	0.20400	0.160000	1.26e-01	6.17e-04	6.92e-03
L1CAM interactions	40	3.19e-05	3.91e-04	0.41900	0.416000	-5.59e-02	5.52e-06	5.41e-01
RAB GEFs exchange GTP for GDP on RABs	61	3.25e-05	3.93e-04	0.32800	0.311000	1.03e-01	2.69e-05	1.65e-01
GTP hydrolysis and joining of the 60S ribosomal subunit	86	3.28e-05	3.93e-04	0.29300	-0.131000	2.62e-01	3.60e-02	2.77e-05
Toll Like Receptor 9 (TLR9) Cascade	70	3.85e-05	4.57e-04	0.30700	0.302000	5.54e-02	1.33e-05	4.24e-01
COPI-independent Golgi-to-ER retrograde traffic	28	4.48e-05	5.26e-04	0.48800	0.488000	-1.45e-02	7.86e-06	8.94e-01
Signaling by Rho GTPases	422	4.62e-05	5.37e-04	0.12400	0.115000	4.75e-02	6.36e-05	9.85e-02
Nervous system development	306	4.78e-05	5.50e-04	0.14800	0.148000	9.59e-03	1.02e-05	7.75e-01
tRNA processing in the nucleus	55	4.93e-05	5.59e-04	0.36000	-0.312000	1.78e-01	6.34e-05	2.24e-02
ROS sensing by NFE2L2	48	4.99e-05	5.59e-04	0.36400	0.357000	7.52e-02	1.96e-05	3.68e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	434	5.00e-05	5.59e-04	0.12200	0.114000	4.48e-02	5.95e-05	1.15e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	76	5.22e-05	5.78e-04	0.30700	-0.199000	2.34e-01	2.73e-03	4.42e-04
Axon guidance	294	5.89e-05	6.46e-04	0.15000	0.149000	8.51e-03	1.24e-05	8.04e-01
Macroautophagy	95	5.96e-05	6.47e-04	0.26200	0.262000	-7.97e-04	1.10e-05	9.89e-01
L13a-mediated translational silencing of Ceruloplasmin expression	85	6.33e-05	6.81e-04	0.28500	-0.126000	2.56e-01	4.49e-02	4.79e-05
Fcgamma receptor (FCGR) dependent phagocytosis	63	6.44e-05	6.86e-04	0.32300	0.320000	-4.09e-02	1.14e-05	5.75e-01
rRNA modification in the nucleus and cytosol	47	7.00e-05	7.40e-04	0.37400	-0.366000	7.77e-02	1.44e-05	3.58e-01
Golgi Associated Vesicle Biogenesis	39	7.20e-05	7.54e-04	0.41400	0.389000	-1.43e-01	2.66e-05	1.23e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	77	7.40e-05	7.68e-04	0.28100	0.270000	7.64e-02	4.23e-05	2.48e-01
Rab regulation of trafficking	89	7.98e-05	8.21e-04	0.26100	0.255000	5.90e-02	3.44e-05	3.38e-01
Selenoamino acid metabolism	76	8.56e-05	8.72e-04	0.29900	-0.200000	2.22e-01	2.58e-03	8.22e-04
Cap-dependent Translation Initiation	93	8.80e-05	8.82e-04	0.26800	-0.117000	2.41e-01	5.15e-02	6.17e-05
Eukaryotic Translation Initiation	93	8.80e-05	8.82e-04	0.26800	-0.117000	2.41e-01	5.15e-02	6.17e-05
Antigen processing-Cross presentation	77	9.66e-05	9.59e-04	0.28300	0.283000	3.69e-03	1.87e-05	9.55e-01
Cargo recognition for clathrin-mediated endocytosis	65	9.74e-05	9.59e-04	0.30400	0.300000	4.84e-02	2.99e-05	5.00e-01
Regulation of PTEN stability and activity	56	9.86e-05	9.62e-04	0.32500	0.315000	7.95e-02	4.69e-05	3.04e-01
EPHB-mediated forward signaling	24	9.94e-05	9.62e-04	0.50600	0.506000	-2.08e-02	1.79e-05	8.60e-01
Signaling by NOTCH1	51	1.15e-04	1.10e-03	0.35100	0.341000	-8.15e-02	2.57e-05	3.15e-01
Oncogenic MAPK signaling	56	1.19e-04	1.14e-03	0.32400	0.320000	4.82e-02	3.50e-05	5.33e-01
Signaling by BRAF and RAF fusions	42	1.23e-04	1.16e-03	0.37000	0.357000	9.68e-02	6.37e-05	2.78e-01
Regulation of HMOX1 expression and activity	55	1.24e-04	1.16e-03	0.32600	0.321000	5.31e-02	3.87e-05	4.96e-01
Rev-mediated nuclear export of HIV RNA	33	1.26e-04	1.17e-03	0.44300	-0.363000	2.53e-01	3.11e-04	1.18e-02
Unwinding of DNA	10	1.32e-04	1.22e-03	0.80000	-0.668000	4.41e-01	2.56e-04	1.57e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	53	1.39e-04	1.27e-03	0.33100	0.330000	3.19e-02	3.37e-05	6.88e-01
PTEN Regulation	114	1.55e-04	1.41e-03	0.22100	0.210000	7.11e-02	1.15e-04	1.92e-01
Cytoprotection by HMOX1	94	1.57e-04	1.41e-03	0.25100	0.250000	-2.17e-02	2.84e-05	7.17e-01
NS1 Mediated Effects on Host Pathways	38	1.60e-04	1.43e-03	0.40700	-0.336000	2.29e-01	3.40e-04	1.45e-02
Signaling by NOTCH4	68	1.74e-04	1.54e-03	0.29300	0.292000	-2.09e-02	3.16e-05	7.66e-01
Signaling by high-kinase activity BRAF mutants	22	1.75e-04	1.54e-03	0.50200	0.490000	1.09e-01	6.99e-05	3.77e-01
MyD88-independent TLR4 cascade	75	1.92e-04	1.67e-03	0.27000	0.259000	7.53e-02	1.07e-04	2.61e-01
TRIF(TICAM1)-mediated TLR4 signaling	75	1.92e-04	1.67e-03	0.27000	0.259000	7.53e-02	1.07e-04	2.61e-01
Defective CFTR causes cystic fibrosis	52	1.97e-04	1.70e-03	0.32600	0.323000	4.94e-02	5.84e-05	5.38e-01
Chromatin modifying enzymes	150	2.03e-04	1.72e-03	0.20100	-0.068900	1.88e-01	1.47e-01	7.27e-05
Chromatin organization	150	2.03e-04	1.72e-03	0.20100	-0.068900	1.88e-01	1.47e-01	7.27e-05
Interactions of Rev with host cellular proteins	34	2.05e-04	1.73e-03	0.42400	-0.346000	2.46e-01	4.88e-04	1.33e-02
Endosomal Sorting Complex Required For Transport (ESCRT)	27	2.08e-04	1.74e-03	0.45000	0.442000	8.18e-02	6.99e-05	4.62e-01
ER-Phagosome pathway	69	2.16e-04	1.74e-03	0.28100	0.276000	5.47e-02	7.69e-05	4.33e-01
PCP/CE pathway	71	2.18e-04	1.74e-03	0.28300	0.282000	-1.37e-02	4.06e-05	8.42e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	20	2.18e-04	1.74e-03	0.52500	0.523000	4.46e-02	5.15e-05	7.30e-01
Neurodegenerative Diseases	20	2.18e-04	1.74e-03	0.52500	0.523000	4.46e-02	5.15e-05	7.30e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	46	2.21e-04	1.74e-03	0.34400	0.340000	5.37e-02	6.66e-05	5.29e-01
Class I MHC mediated antigen processing & presentation	282	2.21e-04	1.74e-03	0.13900	0.130000	4.85e-02	1.91e-04	1.64e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	86	2.21e-04	1.74e-03	0.26600	-0.150000	2.20e-01	1.64e-02	4.40e-04
Nonsense-Mediated Decay (NMD)	86	2.21e-04	1.74e-03	0.26600	-0.150000	2.20e-01	1.64e-02	4.40e-04
Peptide ligand-binding receptors	16	2.22e-04	1.74e-03	0.61200	0.538000	-2.91e-01	1.93e-04	4.38e-02
G alpha (i) signalling events	87	2.28e-04	1.78e-03	0.25700	0.254000	-3.33e-02	4.29e-05	5.92e-01
Insulin receptor recycling	17	2.37e-04	1.84e-03	0.57200	0.572000	-2.03e-02	4.48e-05	8.85e-01
Hh mutants are degraded by ERAD	47	2.44e-04	1.88e-03	0.34000	0.337000	4.17e-02	6.50e-05	6.21e-01
MAPK6/MAPK4 signaling	67	2.57e-04	1.96e-03	0.28200	0.275000	6.15e-02	1.02e-04	3.85e-01
DNA Repair	239	2.58e-04	1.96e-03	0.15700	-0.150000	4.59e-02	7.28e-05	2.25e-01
Hedgehog ligand biogenesis	51	2.73e-04	2.04e-03	0.32500	0.323000	3.07e-02	6.67e-05	7.05e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	2.74e-04	2.04e-03	0.75800	0.710000	-2.66e-01	1.01e-04	1.45e-01
alpha-linolenic acid (ALA) metabolism	10	2.74e-04	2.04e-03	0.75800	0.710000	-2.66e-01	1.01e-04	1.45e-01
Gene Silencing by RNA	60	3.19e-04	2.36e-03	0.31200	-0.211000	2.30e-01	4.84e-03	2.07e-03
Fc epsilon receptor (FCERI) signaling	109	3.34e-04	2.46e-03	0.21700	0.211000	5.35e-02	1.51e-04	3.36e-01
ABC transporter disorders	56	3.49e-04	2.55e-03	0.30700	0.307000	2.57e-03	7.09e-05	9.74e-01
Regulation of ornithine decarboxylase (ODC)	43	3.51e-04	2.55e-03	0.34700	0.345000	4.18e-02	9.33e-05	6.35e-01
Signaling by RAF1 mutants	25	3.70e-04	2.67e-03	0.45100	0.442000	8.93e-02	1.33e-04	4.40e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	33	3.80e-04	2.70e-03	0.40200	0.399000	-5.24e-02	7.37e-05	6.03e-01
Interactions of Vpr with host cellular proteins	33	3.82e-04	2.70e-03	0.41300	-0.357000	2.07e-01	3.84e-04	3.96e-02
SUMOylation	137	3.83e-04	2.70e-03	0.20400	-0.115000	1.69e-01	2.02e-02	6.83e-04
Post-translational protein phosphorylation	32	3.84e-04	2.70e-03	0.40600	0.405000	-2.28e-02	7.34e-05	8.23e-01
Degradation of beta-catenin by the destruction complex	68	4.02e-04	2.81e-03	0.27100	0.259000	7.92e-02	2.30e-04	2.60e-01
Homologous DNA Pairing and Strand Exchange	38	4.12e-04	2.87e-03	0.37700	-0.364000	1.01e-01	1.07e-04	2.81e-01
Negative regulation of MET activity	16	4.19e-04	2.90e-03	0.54600	0.418000	3.50e-01	3.77e-03	1.53e-02
NEP/NS2 Interacts with the Cellular Export Machinery	30	4.31e-04	2.96e-03	0.43100	-0.351000	2.50e-01	8.70e-04	1.78e-02
Interferon alpha/beta signaling	51	4.52e-04	3.09e-03	0.32900	-0.290000	1.55e-01	3.50e-04	5.61e-02
Fanconi Anemia Pathway	28	4.67e-04	3.17e-03	0.43000	-0.428000	4.11e-02	9.00e-05	7.07e-01
Semaphorin interactions	39	4.78e-04	3.23e-03	0.36700	0.360000	-6.98e-02	1.02e-04	4.51e-01
SARS-CoV Infections	115	4.89e-04	3.28e-03	0.20300	0.172000	1.08e-01	1.50e-03	4.56e-02
Hyaluronan uptake and degradation	10	5.02e-04	3.36e-03	0.73300	0.662000	-3.15e-01	2.87e-04	8.48e-02
Negative regulation of FLT3	13	5.13e-04	3.40e-03	0.60500	0.215000	5.65e-01	1.80e-01	4.16e-04
COPII-mediated vesicle transport	51	5.15e-04	3.40e-03	0.31000	0.305000	5.64e-02	1.72e-04	4.86e-01
GPCR downstream signalling	183	5.72e-04	3.75e-03	0.16800	0.166000	-2.34e-02	1.14e-04	5.87e-01
CLEC7A (Dectin-1) signaling	84	5.80e-04	3.78e-03	0.24100	0.240000	2.60e-02	1.50e-04	6.81e-01
Budding and maturation of HIV virion	24	5.88e-04	3.82e-03	0.45500	0.455000	-2.15e-02	1.16e-04	8.55e-01
RHO GTPase cycle	281	5.98e-04	3.86e-03	0.13100	0.124000	4.17e-02	3.83e-04	2.33e-01
Hh mutants abrogate ligand secretion	48	6.19e-04	3.97e-03	0.31800	0.317000	2.62e-02	1.50e-04	7.54e-01
Hyaluronan metabolism	11	6.49e-04	4.11e-03	0.68700	0.622000	-2.91e-01	3.51e-04	9.46e-02
RHO GTPases Activate ROCKs	13	6.50e-04	4.11e-03	0.60400	0.598000	8.86e-02	1.90e-04	5.80e-01
Neddylation	179	6.51e-04	4.11e-03	0.16100	0.139000	8.06e-02	1.43e-03	6.42e-02
RHO GTPase Effectors	184	6.76e-04	4.24e-03	0.15900	0.147000	6.17e-02	6.52e-04	1.51e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	42	6.79e-04	4.24e-03	0.33500	0.331000	5.31e-02	2.07e-04	5.52e-01
Toll Like Receptor 3 (TLR3) Cascade	75	6.90e-04	4.29e-03	0.24900	0.241000	6.51e-02	3.24e-04	3.31e-01
Smooth Muscle Contraction	19	7.14e-04	4.41e-03	0.52400	0.419000	-3.15e-01	1.57e-03	1.76e-02
Degradation of the extracellular matrix	35	7.18e-04	4.42e-03	0.36900	0.368000	2.57e-02	1.69e-04	7.93e-01
Interferon Signaling	142	7.30e-04	4.44e-03	0.19300	-0.148000	1.23e-01	2.39e-03	1.14e-02
Signaling by MET	42	7.31e-04	4.44e-03	0.32700	0.294000	1.45e-01	1.00e-03	1.05e-01
Arachidonic acid metabolism	20	7.55e-04	4.54e-03	0.50700	0.260000	-4.35e-01	4.43e-02	7.52e-04
HSP90 chaperone cycle for steroid hormone receptors (SHR)	32	7.55e-04	4.54e-03	0.38300	0.380000	4.50e-02	2.02e-04	6.60e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	28	7.61e-04	4.54e-03	0.42900	-0.361000	2.32e-01	9.57e-04	3.36e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	28	7.61e-04	4.54e-03	0.42900	-0.361000	2.32e-01	9.57e-04	3.36e-02
Degradation of DVL	48	7.78e-04	4.56e-03	0.31100	0.306000	5.17e-02	2.44e-04	5.36e-01
Degradation of GLI2 by the proteasome	50	7.80e-04	4.56e-03	0.30500	0.301000	4.64e-02	2.33e-04	5.71e-01
GLI3 is processed to GLI3R by the proteasome	50	7.80e-04	4.56e-03	0.30500	0.301000	4.64e-02	2.33e-04	5.71e-01
Vpr-mediated nuclear import of PICs	32	7.82e-04	4.56e-03	0.40100	-0.339000	2.13e-01	9.06e-04	3.71e-02
Antiviral mechanism by IFN-stimulated genes	77	7.90e-04	4.57e-03	0.25900	-0.212000	1.48e-01	1.30e-03	2.48e-02
Translation	234	7.91e-04	4.57e-03	0.14900	-0.064500	1.34e-01	9.14e-02	4.48e-04
Signaling by GPCR	199	7.99e-04	4.60e-03	0.15800	0.155000	-3.16e-02	1.77e-04	4.45e-01
Interleukin-17 signaling	53	8.22e-04	4.69e-03	0.29400	0.289000	5.56e-02	2.80e-04	4.85e-01
Signaling by CSF3 (G-CSF)	24	8.23e-04	4.69e-03	0.44400	0.444000	-1.17e-02	1.68e-04	9.21e-01
Beta-catenin independent WNT signaling	105	8.37e-04	4.74e-03	0.21100	0.211000	1.35e-02	1.96e-04	8.12e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	29	8.74e-04	4.85e-03	0.39600	0.390000	6.80e-02	2.79e-04	5.26e-01
Signaling by RAS mutants	29	8.74e-04	4.85e-03	0.39600	0.390000	6.80e-02	2.79e-04	5.26e-01
Signaling by moderate kinase activity BRAF mutants	29	8.74e-04	4.85e-03	0.39600	0.390000	6.80e-02	2.79e-04	5.26e-01
Signaling downstream of RAS mutants	29	8.74e-04	4.85e-03	0.39600	0.390000	6.80e-02	2.79e-04	5.26e-01
C-type lectin receptors (CLRs)	100	8.76e-04	4.85e-03	0.21500	0.214000	2.31e-02	2.28e-04	6.91e-01
Signal transduction by L1	11	8.95e-04	4.93e-03	0.65500	0.652000	-5.67e-02	1.79e-04	7.45e-01
Nuclear import of Rev protein	31	9.43e-04	5.17e-03	0.40200	-0.327000	2.35e-01	1.65e-03	2.37e-02
MAP kinase activation	50	9.93e-04	5.42e-03	0.29900	0.293000	5.67e-02	3.39e-04	4.88e-01
Metabolism of non-coding RNA	47	1.07e-03	5.79e-03	0.32300	-0.277000	1.67e-01	1.05e-03	4.77e-02
snRNP Assembly	47	1.07e-03	5.79e-03	0.32300	-0.277000	1.67e-01	1.05e-03	4.77e-02
Degradation of GLI1 by the proteasome	51	1.09e-03	5.88e-03	0.29600	0.295000	2.86e-02	2.79e-04	7.24e-01
Presynaptic phase of homologous DNA pairing and strand exchange	35	1.12e-03	5.97e-03	0.37000	-0.341000	1.44e-01	4.78e-04	1.42e-01
HATs acetylate histones	58	1.15e-03	6.10e-03	0.29100	-0.169000	2.36e-01	2.59e-02	1.91e-03
Glycerophospholipid biosynthesis	71	1.15e-03	6.11e-03	0.25300	0.253000	-1.10e-02	2.37e-04	8.73e-01
Vif-mediated degradation of APOBEC3G	43	1.19e-03	6.28e-03	0.31900	0.315000	5.07e-02	3.64e-04	5.66e-01
FLT3 Signaling	33	1.20e-03	6.29e-03	0.35400	0.246000	2.54e-01	1.47e-02	1.15e-02
Late endosomal microautophagy	23	1.21e-03	6.33e-03	0.43900	0.438000	1.77e-02	2.75e-04	8.83e-01
Resolution of Abasic Sites (AP sites)	30	1.23e-03	6.41e-03	0.38500	-0.385000	-3.46e-03	2.67e-04	9.74e-01
Hedgehog ‘on’ state	61	1.26e-03	6.54e-03	0.26800	0.267000	2.35e-02	3.17e-04	7.51e-01
SUMO E3 ligases SUMOylate target proteins	131	1.27e-03	6.54e-03	0.19300	-0.109000	1.58e-01	3.12e-02	1.82e-03
RHO GTPases activate PKNs	25	1.28e-03	6.56e-03	0.40700	0.361000	1.89e-01	1.82e-03	1.03e-01
Transport of bile salts and organic acids, metal ions and amine compounds	30	1.30e-03	6.64e-03	0.38600	0.385000	-3.26e-02	2.66e-04	7.58e-01
Regulation of Apoptosis	45	1.31e-03	6.69e-03	0.31000	0.307000	4.11e-02	3.71e-04	6.34e-01
FCERI mediated NF-kB activation	64	1.37e-03	6.94e-03	0.25400	0.232000	1.04e-01	1.37e-03	1.49e-01
Transferrin endocytosis and recycling	19	1.37e-03	6.94e-03	0.48600	0.480000	-7.60e-02	2.94e-04	5.66e-01
Negative regulation of NOTCH4 signaling	48	1.40e-03	7.03e-03	0.30100	0.301000	1.03e-02	3.17e-04	9.02e-01
Export of Viral Ribonucleoproteins from Nucleus	31	1.50e-03	7.53e-03	0.38900	-0.313000	2.30e-01	2.55e-03	2.66e-02
SLC-mediated transmembrane transport	97	1.51e-03	7.54e-03	0.22100	0.169000	-1.42e-01	4.04e-03	1.62e-02
NIK–>noncanonical NF-kB signaling	51	1.59e-03	7.91e-03	0.28800	0.287000	2.16e-02	3.93e-04	7.90e-01
Uptake and function of anthrax toxins	10	1.65e-03	8.10e-03	0.65300	0.653000	-1.22e-02	3.53e-04	9.47e-01
Dectin-1 mediated noncanonical NF-kB signaling	52	1.65e-03	8.10e-03	0.28300	0.281000	3.87e-02	4.74e-04	6.30e-01
Regulation of HSF1-mediated heat shock response	66	1.65e-03	8.10e-03	0.26200	-0.105000	2.41e-01	1.42e-01	7.37e-04
MTOR signalling	37	1.71e-03	8.29e-03	0.33600	0.334000	3.01e-02	4.37e-04	7.52e-01
RAC2 GTPase cycle	58	1.71e-03	8.29e-03	0.27600	0.267000	-7.18e-02	4.50e-04	3.45e-01
Respiratory electron transport	81	1.71e-03	8.29e-03	0.23600	0.218000	-9.02e-02	7.04e-04	1.61e-01
Cell Cycle	515	1.78e-03	8.59e-03	0.09650	-0.051800	8.14e-02	4.78e-02	1.87e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	44	1.85e-03	8.77e-03	0.30300	0.295000	6.82e-02	7.15e-04	4.34e-01
p53-Independent DNA Damage Response	44	1.85e-03	8.77e-03	0.30300	0.295000	6.82e-02	7.15e-04	4.34e-01
p53-Independent G1/S DNA damage checkpoint	44	1.85e-03	8.77e-03	0.30300	0.295000	6.82e-02	7.15e-04	4.34e-01
TCF dependent signaling in response to WNT	117	1.85e-03	8.77e-03	0.18500	0.173000	6.44e-02	1.25e-03	2.31e-01
Transport of Ribonucleoproteins into the Host Nucleus	30	1.90e-03	8.96e-03	0.38700	-0.325000	2.11e-01	2.08e-03	4.57e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	82	1.92e-03	9.02e-03	0.23200	0.217000	-8.27e-02	7.01e-04	1.97e-01
TP53 Regulates Transcription of DNA Repair Genes	51	1.98e-03	9.30e-03	0.29600	-0.157000	2.51e-01	5.22e-02	1.96e-03
RHOC GTPase cycle	49	2.04e-03	9.53e-03	0.28100	0.253000	1.21e-01	2.18e-03	1.42e-01
Cross-presentation of soluble exogenous antigens (endosomes)	38	2.10e-03	9.77e-03	0.32600	0.325000	2.71e-02	5.34e-04	7.73e-01
Opioid Signalling	56	2.13e-03	9.88e-03	0.27000	0.270000	8.96e-03	4.95e-04	9.08e-01
Signaling by Insulin receptor	42	2.16e-03	9.96e-03	0.30800	0.306000	4.05e-02	6.17e-04	6.50e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	46	2.17e-03	9.96e-03	0.29500	0.294000	3.05e-02	5.76e-04	7.21e-01
Integration of energy metabolism	58	2.18e-03	9.98e-03	0.27000	0.264000	-5.52e-02	5.15e-04	4.68e-01
CD28 dependent PI3K/Akt signaling	18	2.22e-03	1.01e-02	0.49400	-0.272000	4.12e-01	4.60e-02	2.48e-03
Phospholipid metabolism	129	2.26e-03	1.02e-02	0.17600	0.174000	2.65e-02	6.82e-04	6.04e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	41	2.29e-03	1.02e-02	0.32000	0.310000	-7.89e-02	5.90e-04	3.82e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	41	2.29e-03	1.02e-02	0.32000	0.310000	-7.89e-02	5.90e-04	3.82e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	41	2.29e-03	1.02e-02	0.32000	0.310000	-7.89e-02	5.90e-04	3.82e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	41	2.29e-03	1.02e-02	0.32000	0.310000	-7.89e-02	5.90e-04	3.82e-01
Signaling by NOTCH1 in Cancer	41	2.29e-03	1.02e-02	0.32000	0.310000	-7.89e-02	5.90e-04	3.82e-01
TCR signaling	88	2.30e-03	1.02e-02	0.20700	0.160000	1.31e-01	9.69e-03	3.46e-02
Signalling to ERKs	26	2.31e-03	1.02e-02	0.38300	0.356000	1.41e-01	1.69e-03	2.13e-01
Chromosome Maintenance	74	2.34e-03	1.03e-02	0.23700	-0.233000	4.59e-02	5.43e-04	4.96e-01
Amino acids regulate mTORC1	43	2.44e-03	1.07e-02	0.30400	0.303000	1.60e-02	5.88e-04	8.56e-01
Cellular response to heat stress	79	2.44e-03	1.07e-02	0.23200	-0.087000	2.15e-01	1.82e-01	9.63e-04
Lysosome Vesicle Biogenesis	25	2.46e-03	1.07e-02	0.41200	0.380000	-1.59e-01	1.02e-03	1.69e-01
HIV Infection	188	2.56e-03	1.11e-02	0.14100	0.083400	1.14e-01	5.00e-02	7.54e-03
DNA Double-Strand Break Repair	113	2.59e-03	1.12e-02	0.19200	-0.186000	4.78e-02	6.74e-04	3.82e-01
TP53 Regulates Metabolic Genes	72	2.61e-03	1.12e-02	0.24100	0.227000	-8.10e-02	8.78e-04	2.36e-01
Activated NOTCH1 Transmits Signal to the Nucleus	19	2.61e-03	1.12e-02	0.44900	0.441000	8.39e-02	8.80e-04	5.27e-01
PI3K/AKT Signaling in Cancer	50	2.63e-03	1.12e-02	0.27100	0.160000	2.18e-01	5.02e-02	7.72e-03
The role of GTSE1 in G2/M progression after G2 checkpoint	52	2.63e-03	1.12e-02	0.27400	0.273000	2.34e-02	6.77e-04	7.70e-01
Transport of the SLBP independent Mature mRNA	33	2.69e-03	1.14e-02	0.35900	-0.303000	1.93e-01	2.62e-03	5.58e-02
PPARA activates gene expression	79	2.72e-03	1.15e-02	0.21800	0.206000	7.12e-02	1.59e-03	2.75e-01
Vpu mediated degradation of CD4	44	2.81e-03	1.18e-02	0.29500	0.293000	3.66e-02	7.92e-04	6.75e-01
Cargo concentration in the ER	20	2.83e-03	1.19e-02	0.44300	0.442000	-2.12e-02	6.18e-04	8.70e-01
ABC-family proteins mediated transport	72	2.92e-03	1.22e-02	0.23000	0.227000	3.39e-02	8.79e-04	6.19e-01
Downstream TCR signaling	72	2.95e-03	1.23e-02	0.22400	0.184000	1.27e-01	7.01e-03	6.29e-02
Antigen processing: Ubiquitination & Proteasome degradation	236	2.96e-03	1.23e-02	0.12500	0.099000	7.55e-02	9.30e-03	4.72e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	20	3.01e-03	1.25e-02	0.43500	-0.433000	-4.24e-02	8.01e-04	7.43e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	19	3.05e-03	1.25e-02	0.45300	0.451000	-4.40e-02	6.64e-04	7.40e-01
Ion channel transport	80	3.05e-03	1.25e-02	0.21900	0.219000	9.99e-03	7.36e-04	8.78e-01
AKT phosphorylates targets in the cytosol	13	3.08e-03	1.26e-02	0.52500	0.467000	2.41e-01	3.57e-03	1.33e-01
Processing of Capped Intron-Containing Pre-mRNA	191	3.29e-03	1.34e-02	0.14600	-0.052200	1.37e-01	2.16e-01	1.20e-03
Ubiquitin-dependent degradation of Cyclin D	44	3.42e-03	1.39e-02	0.28800	0.282000	5.77e-02	1.20e-03	5.08e-01
InlB-mediated entry of Listeria monocytogenes into host cell	11	3.47e-03	1.40e-02	0.56200	0.431000	3.60e-01	1.33e-02	3.87e-02
CDC42 GTPase cycle	95	3.58e-03	1.44e-02	0.20300	0.198000	-4.48e-02	8.92e-04	4.52e-01
Nuclear Events (kinase and transcription factor activation)	43	3.62e-03	1.45e-02	0.28900	0.278000	7.73e-02	1.62e-03	3.81e-01
EGFR downregulation	20	3.68e-03	1.48e-02	0.43000	0.430000	1.38e-02	8.82e-04	9.15e-01
The citric acid (TCA) cycle and respiratory electron transport	120	3.80e-03	1.52e-02	0.17900	0.177000	-2.61e-02	8.64e-04	6.23e-01
Metabolism of polyamines	48	3.83e-03	1.52e-02	0.27300	0.265000	6.44e-02	1.52e-03	4.41e-01
Growth hormone receptor signaling	17	3.83e-03	1.52e-02	0.45500	0.430000	1.46e-01	2.14e-03	2.96e-01
Iron uptake and transport	38	3.92e-03	1.55e-02	0.31300	0.312000	-1.58e-02	8.76e-04	8.67e-01
Transport of the SLBP Dependant Mature mRNA	34	3.92e-03	1.55e-02	0.34300	-0.280000	1.98e-01	4.83e-03	4.56e-02
p75 NTR receptor-mediated signalling	60	3.96e-03	1.55e-02	0.24500	0.244000	2.95e-02	1.12e-03	6.93e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	4.07e-03	1.59e-02	0.49900	0.477000	1.48e-01	2.02e-03	3.39e-01
HDR through Homologous Recombination (HRR)	58	4.13e-03	1.61e-02	0.25400	-0.252000	3.40e-02	9.37e-04	6.55e-01
Base Excision Repair	36	4.14e-03	1.61e-02	0.31800	-0.318000	-1.94e-03	9.68e-04	9.84e-01
VEGFA-VEGFR2 Pathway	71	4.26e-03	1.65e-02	0.22200	0.213000	6.08e-02	1.94e-03	3.77e-01
Metabolism of carbohydrates	177	4.32e-03	1.67e-02	0.14600	0.144000	-2.15e-02	9.93e-04	6.24e-01
Autodegradation of Cdh1 by Cdh1:APC/C	56	4.46e-03	1.71e-02	0.24700	0.230000	8.87e-02	2.90e-03	2.52e-01
RAC1 GTPase cycle	109	4.47e-03	1.71e-02	0.17900	0.175000	3.80e-02	1.63e-03	4.95e-01
Activation of NF-kappaB in B cells	57	4.73e-03	1.81e-02	0.24600	0.241000	4.81e-02	1.64e-03	5.31e-01
RHOA GTPase cycle	91	4.83e-03	1.84e-02	0.19300	0.181000	6.64e-02	2.91e-03	2.75e-01
ISG15 antiviral mechanism	70	4.83e-03	1.84e-02	0.23500	-0.179000	1.53e-01	9.83e-03	2.73e-02
SUMOylation of SUMOylation proteins	32	5.18e-03	1.96e-02	0.34500	-0.272000	2.12e-01	7.79e-03	3.85e-02
Plasma lipoprotein clearance	19	5.23e-03	1.97e-02	0.43600	0.425000	-1.00e-01	1.36e-03	4.49e-01
Collagen degradation	14	5.32e-03	2.00e-02	0.47900	0.378000	2.94e-01	1.43e-02	5.69e-02
mTORC1-mediated signalling	22	5.39e-03	2.02e-02	0.39200	0.389000	5.50e-02	1.62e-03	6.55e-01
TNFR2 non-canonical NF-kB pathway	67	5.42e-03	2.02e-02	0.22100	0.200000	9.40e-02	4.74e-03	1.84e-01
Regulation of lipid metabolism by PPARalpha	81	5.50e-03	2.05e-02	0.20200	0.189000	7.13e-02	3.42e-03	2.69e-01
Transmission across Chemical Synapses	95	5.57e-03	2.07e-02	0.20000	0.150000	-1.32e-01	1.18e-02	2.70e-02
Extracellular matrix organization	91	5.59e-03	2.07e-02	0.19900	0.194000	-4.52e-02	1.45e-03	4.57e-01
Autodegradation of the E3 ubiquitin ligase COP1	43	5.61e-03	2.07e-02	0.27700	0.265000	7.97e-02	2.66e-03	3.67e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	64	5.66e-03	2.08e-02	0.22700	0.217000	6.63e-02	2.73e-03	3.60e-01
Telomere C-strand (Lagging Strand) Synthesis	29	5.73e-03	2.10e-02	0.34700	-0.345000	4.13e-02	1.32e-03	7.01e-01
Regulation of RUNX3 expression and activity	49	5.76e-03	2.11e-02	0.25900	0.251000	6.48e-02	2.38e-03	4.34e-01
Spry regulation of FGF signaling	15	6.19e-03	2.25e-02	0.46100	0.429000	1.70e-01	4.06e-03	2.55e-01
RHOJ GTPase cycle	36	6.21e-03	2.25e-02	0.31400	0.300000	-9.02e-02	1.84e-03	3.49e-01
Prolonged ERK activation events	13	6.24e-03	2.25e-02	0.49100	0.413000	2.64e-01	9.90e-03	9.90e-02
APC/C:Cdc20 mediated degradation of Securin	58	6.25e-03	2.25e-02	0.23600	0.223000	7.56e-02	3.35e-03	3.20e-01
Formation of the ternary complex, and subsequently, the 43S complex	40	6.27e-03	2.25e-02	0.29800	-0.099600	2.81e-01	2.76e-01	2.12e-03
Late Phase of HIV Life Cycle	115	6.27e-03	2.25e-02	0.17200	0.002320	1.72e-01	9.66e-01	1.52e-03
SUMOylation of DNA damage response and repair proteins	67	6.53e-03	2.33e-02	0.23300	-0.197000	1.24e-01	5.37e-03	8.08e-02
Signaling by VEGF	73	6.53e-03	2.33e-02	0.21000	0.200000	6.19e-02	3.16e-03	3.62e-01
Response of Mtb to phagocytosis	20	6.80e-03	2.42e-02	0.39700	0.373000	1.34e-01	3.88e-03	2.99e-01
Protein ubiquitination	59	6.95e-03	2.46e-02	0.23200	0.225000	5.81e-02	2.86e-03	4.41e-01
HCMV Early Events	50	7.18e-03	2.54e-02	0.26800	-0.198000	1.80e-01	1.54e-02	2.82e-02
SUMOylation of DNA replication proteins	43	7.27e-03	2.56e-02	0.28800	-0.194000	2.13e-01	2.76e-02	1.60e-02
Plasma lipoprotein assembly, remodeling, and clearance	32	7.29e-03	2.56e-02	0.32200	0.321000	-2.98e-02	1.70e-03	7.70e-01
Transcriptional regulation by small RNAs	43	7.32e-03	2.56e-02	0.28800	-0.200000	2.08e-01	2.37e-02	1.86e-02
Constitutive Signaling by AKT1 E17K in Cancer	23	7.36e-03	2.57e-02	0.36400	0.168000	3.23e-01	1.64e-01	7.32e-03
Translocation of SLC2A4 (GLUT4) to the plasma membrane	45	7.40e-03	2.58e-02	0.27300	0.270000	-4.07e-02	1.78e-03	6.37e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	56	7.54e-03	2.61e-02	0.23800	0.234000	4.21e-02	2.50e-03	5.87e-01
Extension of Telomeres	44	7.54e-03	2.61e-02	0.27700	-0.270000	6.17e-02	1.98e-03	4.80e-01
SUMOylation of RNA binding proteins	42	7.62e-03	2.62e-02	0.29000	-0.218000	1.91e-01	1.47e-02	3.20e-02
Transport of Mature mRNA Derived from an Intronless Transcript	40	7.63e-03	2.62e-02	0.29400	-0.269000	1.18e-01	3.27e-03	1.97e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	10	7.72e-03	2.65e-02	0.59300	0.404000	-4.34e-01	2.71e-02	1.75e-02
Nuclear Pore Complex (NPC) Disassembly	34	7.74e-03	2.65e-02	0.32200	-0.223000	2.32e-01	2.46e-02	1.93e-02
Phosphorylation of CD3 and TCR zeta chains	10	7.82e-03	2.66e-02	0.58300	-0.205000	5.46e-01	2.62e-01	2.80e-03
SCF-beta-TrCP mediated degradation of Emi1	47	7.85e-03	2.67e-02	0.25700	0.248000	6.60e-02	3.30e-03	4.34e-01
Postmitotic nuclear pore complex (NPC) reformation	26	7.92e-03	2.68e-02	0.36500	-0.318000	1.78e-01	5.02e-03	1.16e-01
Sphingolipid metabolism	50	7.94e-03	2.68e-02	0.25900	0.251000	-6.47e-02	2.19e-03	4.29e-01
RHO GTPases activate PAKs	13	8.08e-03	2.72e-02	0.49300	0.492000	2.84e-02	2.11e-03	8.59e-01
RAF activation	28	8.16e-03	2.74e-02	0.33000	0.315000	9.71e-02	3.89e-03	3.74e-01
WNT5A-dependent internalization of FZD4	10	8.25e-03	2.76e-02	0.56500	0.564000	-8.45e-03	2.00e-03	9.63e-01
HDR through Single Strand Annealing (SSA)	34	8.76e-03	2.92e-02	0.30900	-0.304000	5.31e-02	2.17e-03	5.92e-01
Infection with Mycobacterium tuberculosis	22	8.84e-03	2.94e-02	0.37100	0.364000	7.57e-02	3.16e-03	5.39e-01
CDK-mediated phosphorylation and removal of Cdc6	62	8.90e-03	2.95e-02	0.21800	0.197000	9.43e-02	7.43e-03	2.00e-01
Transcriptional regulation by RUNX3	75	8.93e-03	2.95e-02	0.20000	0.191000	6.01e-02	4.33e-03	3.69e-01
Neuronal System	128	8.99e-03	2.97e-02	0.16400	0.118000	-1.14e-01	2.17e-02	2.63e-02
Neurotransmitter release cycle	19	9.07e-03	2.99e-02	0.40600	0.012300	-4.06e-01	9.26e-01	2.19e-03
CDT1 association with the CDC6:ORC:origin complex	50	9.15e-03	2.99e-02	0.24200	0.211000	1.18e-01	1.01e-02	1.49e-01
Homology Directed Repair	88	9.17e-03	2.99e-02	0.19200	-0.188000	3.61e-02	2.32e-03	5.60e-01
Signaling by Hedgehog	97	9.17e-03	2.99e-02	0.18200	0.180000	-2.54e-02	2.23e-03	6.66e-01
Inactivation of CSF3 (G-CSF) signaling	19	9.31e-03	3.03e-02	0.40300	0.403000	1.50e-02	2.40e-03	9.10e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	54	9.53e-03	3.09e-02	0.25000	-0.167000	1.86e-01	3.40e-02	1.82e-02
Assembly of the pre-replicative complex	59	9.55e-03	3.09e-02	0.22000	0.145000	1.66e-01	5.41e-02	2.81e-02
G-protein beta:gamma signalling	20	9.61e-03	3.10e-02	0.37900	0.330000	1.88e-01	1.08e-02	1.47e-01
SARS-CoV-2 Infection	56	9.70e-03	3.12e-02	0.22700	0.198000	1.11e-01	1.04e-02	1.53e-01
Notch-HLH transcription pathway	21	9.74e-03	3.13e-02	0.39300	0.370000	-1.31e-01	3.32e-03	2.98e-01
NOTCH1 Intracellular Domain Regulates Transcription	37	9.79e-03	3.13e-02	0.29700	0.274000	-1.14e-01	3.91e-03	2.30e-01
Amyloid fiber formation	24	9.88e-03	3.16e-02	0.36100	0.358000	-4.33e-02	2.39e-03	7.14e-01
Regulation of expression of SLITs and ROBOs	122	1.01e-02	3.23e-02	0.16000	-0.008970	1.59e-01	8.65e-01	2.45e-03
tRNA modification in the nucleus and cytosol	34	1.02e-02	3.24e-02	0.30000	-0.300000	1.25e-02	2.48e-03	8.99e-01
ESR-mediated signaling	112	1.03e-02	3.25e-02	0.15900	0.104000	1.21e-01	5.87e-02	2.80e-02
RHOG GTPase cycle	51	1.04e-02	3.29e-02	0.24600	0.245000	-2.67e-02	2.53e-03	7.42e-01
Regulation of RAS by GAPs	56	1.06e-02	3.35e-02	0.22800	0.219000	6.21e-02	4.66e-03	4.22e-01
RHO GTPases activate CIT	14	1.09e-02	3.43e-02	0.44700	0.396000	2.09e-01	1.04e-02	1.76e-01
Stabilization of p53	48	1.10e-02	3.45e-02	0.24400	0.233000	7.40e-02	5.35e-03	3.76e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	41	1.11e-02	3.45e-02	0.28000	-0.250000	1.25e-01	5.58e-03	1.68e-01
Energy dependent regulation of mTOR by LKB1-AMPK	26	1.12e-02	3.50e-02	0.34200	0.339000	-4.65e-02	2.77e-03	6.82e-01
Degradation of AXIN	47	1.13e-02	3.53e-02	0.24800	0.242000	5.17e-02	4.12e-03	5.40e-01
Interleukin-4 and Interleukin-13 signaling	48	1.14e-02	3.53e-02	0.24300	0.228000	8.37e-02	6.42e-03	3.16e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	62	1.19e-02	3.69e-02	0.21200	0.196000	8.10e-02	7.73e-03	2.71e-01
SUMOylation of ubiquitinylation proteins	37	1.20e-02	3.69e-02	0.29400	-0.209000	2.08e-01	2.81e-02	2.90e-02
Regulated Necrosis	42	1.20e-02	3.70e-02	0.26700	0.265000	-3.26e-02	2.97e-03	7.15e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	63	1.21e-02	3.71e-02	0.21000	0.194000	8.02e-02	7.82e-03	2.72e-01
Signaling by NOTCH2	18	1.21e-02	3.71e-02	0.41000	0.402000	-7.80e-02	3.15e-03	5.67e-01
Cell Cycle Checkpoints	222	1.23e-02	3.75e-02	0.11900	-0.038200	1.13e-01	3.30e-01	4.07e-03
RHOQ GTPase cycle	39	1.24e-02	3.77e-02	0.27900	0.270000	-7.19e-02	3.56e-03	4.38e-01
FCERI mediated MAPK activation	25	1.24e-02	3.77e-02	0.34300	0.342000	-2.25e-02	3.05e-03	8.45e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	65	1.26e-02	3.81e-02	0.20600	0.189000	8.21e-02	8.69e-03	2.53e-01
HIV Life Cycle	127	1.26e-02	3.82e-02	0.15300	-0.007470	1.52e-01	8.85e-01	3.13e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	48	1.29e-02	3.88e-02	0.24700	-0.016900	2.46e-01	8.40e-01	3.18e-03
Cell Cycle, Mitotic	417	1.33e-02	4.00e-02	0.08680	-0.026200	8.28e-02	3.66e-01	4.22e-03
Transcriptional regulation by RUNX2	83	1.36e-02	4.07e-02	0.18800	0.186000	-2.19e-02	3.39e-03	7.31e-01
Signaling by Nuclear Receptors	147	1.37e-02	4.10e-02	0.13500	0.101000	8.90e-02	3.53e-02	6.37e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	66	1.38e-02	4.10e-02	0.20300	0.190000	7.11e-02	7.81e-03	3.19e-01
Listeria monocytogenes entry into host cells	14	1.38e-02	4.10e-02	0.43300	0.301000	3.11e-01	5.14e-02	4.40e-02
Cellular response to starvation	119	1.39e-02	4.12e-02	0.15700	-0.017400	1.56e-01	7.44e-01	3.46e-03
TBC/RABGAPs	38	1.41e-02	4.18e-02	0.27500	0.274000	-2.70e-02	3.52e-03	7.74e-01
Downstream signaling events of B Cell Receptor (BCR)	70	1.43e-02	4.22e-02	0.19500	0.176000	8.37e-02	1.10e-02	2.27e-01
Ribosomal scanning and start codon recognition	47	1.45e-02	4.26e-02	0.24800	-0.035800	2.45e-01	6.71e-01	3.68e-03
COPI-dependent Golgi-to-ER retrograde traffic	64	1.46e-02	4.29e-02	0.20700	0.203000	3.99e-02	5.14e-03	5.81e-01
Diseases of carbohydrate metabolism	22	1.47e-02	4.31e-02	0.36700	0.344000	-1.28e-01	5.28e-03	2.98e-01
Regulation of TP53 Activity	131	1.49e-02	4.36e-02	0.15300	-0.114000	1.02e-01	2.48e-02	4.38e-02
Beta-catenin phosphorylation cascade	15	1.50e-02	4.37e-02	0.41800	0.380000	1.74e-01	1.09e-02	2.42e-01
Signaling by EGFR	36	1.51e-02	4.39e-02	0.27800	0.278000	2.35e-03	3.93e-03	9.81e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	28	1.52e-02	4.40e-02	0.30300	0.206000	2.22e-01	5.99e-02	4.19e-02
XBP1(S) activates chaperone genes	36	1.53e-02	4.42e-02	0.26900	0.241000	1.20e-01	1.25e-02	2.13e-01
Class A/1 (Rhodopsin-like receptors)	40	1.53e-02	4.42e-02	0.27500	0.206000	-1.83e-01	2.47e-02	4.56e-02
G beta:gamma signalling through PI3Kgamma	16	1.55e-02	4.46e-02	0.40000	0.227000	3.30e-01	1.16e-01	2.24e-02
Negative regulation of FGFR1 signaling	17	1.56e-02	4.46e-02	0.38900	0.334000	1.99e-01	1.72e-02	1.55e-01
Negative regulation of FGFR2 signaling	17	1.56e-02	4.46e-02	0.38900	0.334000	1.99e-01	1.72e-02	1.55e-01
Negative regulation of FGFR3 signaling	17	1.56e-02	4.46e-02	0.38900	0.334000	1.99e-01	1.72e-02	1.55e-01
Negative regulation of FGFR4 signaling	17	1.56e-02	4.46e-02	0.38900	0.334000	1.99e-01	1.72e-02	1.55e-01
Lagging Strand Synthesis	17	1.59e-02	4.51e-02	0.41000	-0.399000	9.15e-02	4.40e-03	5.14e-01
MAPK targets/ Nuclear events mediated by MAP kinases	24	1.61e-02	4.55e-02	0.32700	0.293000	1.45e-01	1.29e-02	2.19e-01
G-protein mediated events	32	1.62e-02	4.57e-02	0.30100	0.281000	-1.07e-01	5.91e-03	2.95e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	15	1.64e-02	4.63e-02	0.42700	0.427000	-5.58e-03	4.24e-03	9.70e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	19	1.65e-02	4.64e-02	0.37500	0.372000	4.38e-02	4.97e-03	7.41e-01
Signaling by Leptin	10	1.66e-02	4.65e-02	0.53600	0.503000	-1.86e-01	5.91e-03	3.10e-01
Asymmetric localization of PCP proteins	51	1.66e-02	4.65e-02	0.22900	0.228000	2.50e-02	4.95e-03	7.57e-01
Translation initiation complex formation	47	1.68e-02	4.68e-02	0.24300	-0.029500	2.41e-01	7.27e-01	4.27e-03
Glycogen metabolism	17	1.68e-02	4.69e-02	0.41200	0.376000	-1.68e-01	7.28e-03	2.29e-01
Protein methylation	12	1.78e-02	4.94e-02	0.46200	0.130000	4.43e-01	4.37e-01	7.90e-03
Recycling pathway of L1	16	1.80e-02	5.00e-02	0.40600	0.405000	2.39e-02	5.02e-03	8.69e-01
IRE1alpha activates chaperones	37	1.81e-02	5.00e-02	0.25900	0.216000	1.42e-01	2.29e-02	1.36e-01
Fatty acid metabolism	102	1.85e-02	5.11e-02	0.16900	0.125000	-1.13e-01	2.94e-02	4.85e-02
Viral Messenger RNA Synthesis	40	1.88e-02	5.16e-02	0.26800	-0.203000	1.76e-01	2.68e-02	5.43e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter	25	1.90e-02	5.21e-02	0.33900	-0.245000	2.34e-01	3.42e-02	4.29e-02
RHOH GTPase cycle	28	1.94e-02	5.31e-02	0.29400	0.239000	1.73e-01	2.91e-02	1.14e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	1.96e-02	5.36e-02	0.30500	0.298000	6.89e-02	7.49e-03	5.36e-01
M Phase	291	1.97e-02	5.36e-02	0.09320	0.038600	8.48e-02	2.62e-01	1.36e-02
Prefoldin mediated transfer of substrate to CCT/TriC	17	2.00e-02	5.43e-02	0.38400	0.375000	8.27e-02	7.44e-03	5.55e-01
Mitochondrial tRNA aminoacylation	18	2.03e-02	5.52e-02	0.38700	-0.373000	1.04e-01	6.17e-03	4.44e-01
Metabolism of steroids	81	2.07e-02	5.62e-02	0.18200	0.177000	-4.13e-02	5.90e-03	5.22e-01
PLC beta mediated events	29	2.09e-02	5.65e-02	0.30900	0.269000	-1.52e-01	1.23e-02	1.57e-01
Epigenetic regulation of gene expression	72	2.10e-02	5.65e-02	0.19700	-0.106000	1.66e-01	1.22e-01	1.51e-02
Frs2-mediated activation	11	2.10e-02	5.65e-02	0.46400	0.340000	3.15e-01	5.09e-02	7.05e-02
Regulation of IFNG signaling	13	2.10e-02	5.65e-02	0.43700	0.428000	8.60e-02	7.53e-03	5.92e-01
Telomere Maintenance	55	2.11e-02	5.65e-02	0.22100	-0.211000	6.70e-02	6.86e-03	3.91e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	24	2.12e-02	5.65e-02	0.34100	-0.236000	2.47e-01	4.59e-02	3.67e-02
Potential therapeutics for SARS	60	2.17e-02	5.78e-02	0.19800	0.159000	1.19e-01	3.39e-02	1.11e-01
PCNA-Dependent Long Patch Base Excision Repair	18	2.20e-02	5.84e-02	0.37500	-0.375000	-1.28e-03	5.90e-03	9.93e-01
Signaling by the B Cell Receptor (BCR)	91	2.28e-02	6.04e-02	0.16400	0.160000	3.69e-02	8.72e-03	5.44e-01
RHO GTPases Activate NADPH Oxidases	14	2.32e-02	6.15e-02	0.42100	0.421000	1.15e-02	6.40e-03	9.41e-01
Extra-nuclear estrogen signaling	48	2.33e-02	6.15e-02	0.21900	0.147000	1.63e-01	7.81e-02	5.15e-02
Signaling by NOTCH3	30	2.38e-02	6.28e-02	0.28700	0.286000	1.28e-02	6.69e-03	9.04e-01
Integrin signaling	17	2.40e-02	6.29e-02	0.37200	0.349000	1.28e-01	1.28e-02	3.60e-01
Platelet Aggregation (Plug Formation)	17	2.40e-02	6.29e-02	0.37200	0.349000	1.28e-01	1.28e-02	3.60e-01
Formation of tubulin folding intermediates by CCT/TriC	14	2.40e-02	6.29e-02	0.40800	0.374000	1.64e-01	1.55e-02	2.90e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	47	2.41e-02	6.29e-02	0.22500	0.215000	6.34e-02	1.07e-02	4.53e-01
Transport of Mature Transcript to Cytoplasm	63	2.41e-02	6.29e-02	0.20700	-0.141000	1.52e-01	5.42e-02	3.68e-02
Other semaphorin interactions	10	2.43e-02	6.31e-02	0.51700	0.421000	-3.01e-01	2.13e-02	9.94e-02
Signaling by FLT3 ITD and TKD mutants	13	2.46e-02	6.38e-02	0.44800	0.412000	-1.77e-01	1.01e-02	2.70e-01
Signal amplification	19	2.53e-02	6.55e-02	0.36200	0.359000	-4.48e-02	6.75e-03	7.35e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	21	2.55e-02	6.58e-02	0.32800	0.274000	1.81e-01	3.01e-02	1.51e-01
ERK/MAPK targets	17	2.57e-02	6.63e-02	0.37800	0.378000	-7.53e-03	6.93e-03	9.57e-01
LDL clearance	13	2.58e-02	6.63e-02	0.43600	0.433000	-5.17e-02	6.87e-03	7.47e-01
Diseases associated with the TLR signaling cascade	16	2.60e-02	6.65e-02	0.38300	0.377000	6.88e-02	9.03e-03	6.34e-01
Diseases of Immune System	16	2.60e-02	6.65e-02	0.38300	0.377000	6.88e-02	9.03e-03	6.34e-01
Selective autophagy	48	2.61e-02	6.67e-02	0.22500	0.225000	2.38e-03	7.18e-03	9.77e-01
Platelet sensitization by LDL	13	2.68e-02	6.84e-02	0.42800	0.428000	1.73e-02	7.59e-03	9.14e-01
UCH proteinases	74	2.75e-02	7.00e-02	0.18200	0.180000	-2.45e-02	7.43e-03	7.17e-01
Interleukin-10 signaling	13	2.76e-02	7.00e-02	0.44600	0.269000	-3.56e-01	9.35e-02	2.63e-02
GPCR ligand binding	67	2.81e-02	7.11e-02	0.19700	0.136000	-1.42e-01	5.41e-02	4.47e-02
Thrombin signalling through proteinase activated receptors (PARs)	19	2.94e-02	7.42e-02	0.35100	0.351000	3.74e-03	8.17e-03	9.78e-01
Platelet homeostasis	48	2.97e-02	7.49e-02	0.22100	0.221000	9.00e-06	8.23e-03	1.00e+00
Mitotic Anaphase	193	3.03e-02	7.61e-02	0.10600	0.073900	7.65e-02	7.84e-02	6.86e-02
Regulation of RUNX2 expression and activity	57	3.04e-02	7.63e-02	0.19700	0.183000	7.09e-02	1.68e-02	3.55e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	22	3.10e-02	7.77e-02	0.31100	0.246000	1.90e-01	4.56e-02	1.22e-01
EPH-ephrin mediated repulsion of cells	26	3.15e-02	7.84e-02	0.30700	0.281000	-1.22e-01	1.31e-02	2.83e-01
Deubiquitination	192	3.15e-02	7.84e-02	0.11000	0.110000	2.20e-03	8.89e-03	9.58e-01
SUMOylation of immune response proteins	10	3.15e-02	7.84e-02	0.46000	0.306000	3.44e-01	9.43e-02	5.98e-02
Neurotransmitter receptors and postsynaptic signal transmission	73	3.21e-02	7.97e-02	0.18200	0.173000	-5.66e-02	1.09e-02	4.04e-01
Signaling by ROBO receptors	153	3.29e-02	8.16e-02	0.12000	0.038000	1.13e-01	4.19e-01	1.60e-02
Stimuli-sensing channels	39	3.36e-02	8.32e-02	0.24900	0.225000	-1.06e-01	1.51e-02	2.55e-01
Mitotic Metaphase and Anaphase	194	3.41e-02	8.40e-02	0.10400	0.068700	7.84e-02	1.01e-01	6.12e-02
Oxidative Stress Induced Senescence	54	3.41e-02	8.40e-02	0.19700	0.167000	1.04e-01	3.42e-02	1.85e-01
Chaperonin-mediated protein folding	56	3.42e-02	8.40e-02	0.20100	0.201000	-1.20e-02	9.39e-03	8.77e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	16	3.47e-02	8.49e-02	0.35900	0.282000	2.22e-01	5.08e-02	1.24e-01
Glucagon signaling in metabolic regulation	17	3.47e-02	8.49e-02	0.36100	0.360000	1.94e-02	1.02e-02	8.90e-01
tRNA Aminoacylation	23	3.50e-02	8.54e-02	0.31900	-0.304000	9.44e-02	1.16e-02	4.33e-01
E3 ubiquitin ligases ubiquitinate target proteins	41	3.51e-02	8.55e-02	0.23100	0.231000	2.01e-02	1.07e-02	8.24e-01
Death Receptor Signalling	96	3.53e-02	8.59e-02	0.15300	0.153000	-1.10e-03	9.93e-03	9.85e-01
DARPP-32 events	20	3.54e-02	8.59e-02	0.33000	0.329000	2.91e-02	1.09e-02	8.22e-01
Cellular Senescence	105	3.55e-02	8.60e-02	0.14000	0.101000	9.76e-02	7.59e-02	8.49e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	25	3.56e-02	8.60e-02	0.29300	0.289000	5.13e-02	1.25e-02	6.57e-01
SUMOylation of chromatin organization proteins	49	3.57e-02	8.60e-02	0.22200	-0.176000	1.35e-01	3.32e-02	1.03e-01
Regulation of APC/C activators between G1/S and early anaphase	70	3.73e-02	8.97e-02	0.17100	0.149000	8.34e-02	3.11e-02	2.29e-01
Assembly Of The HIV Virion	14	3.74e-02	8.97e-02	0.38300	0.353000	1.50e-01	2.24e-02	3.31e-01
SARS-CoV-1 Infection	43	3.76e-02	9.01e-02	0.21700	0.166000	1.39e-01	5.96e-02	1.16e-01
G1/S DNA Damage Checkpoints	57	3.82e-02	9.14e-02	0.18900	0.172000	7.96e-02	2.51e-02	3.00e-01
Nuclear Envelope Breakdown	49	3.94e-02	9.37e-02	0.21800	-0.111000	1.87e-01	1.78e-01	2.37e-02
Diseases associated with O-glycosylation of proteins	21	3.94e-02	9.37e-02	0.33100	-0.298000	1.44e-01	1.82e-02	2.54e-01
Signaling by TGFB family members	73	3.95e-02	9.39e-02	0.17800	0.161000	-7.58e-02	1.79e-02	2.64e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	10	3.96e-02	9.39e-02	0.45600	0.449000	7.97e-02	1.40e-02	6.63e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	82	3.98e-02	9.42e-02	0.16400	-0.162000	2.70e-02	1.14e-02	6.73e-01
Glycosaminoglycan metabolism	61	4.02e-02	9.50e-02	0.19300	0.181000	-6.50e-02	1.45e-02	3.81e-01
Rap1 signalling	10	4.08e-02	9.62e-02	0.44700	0.183000	4.08e-01	3.17e-01	2.56e-02
RAC3 GTPase cycle	59	4.16e-02	9.78e-02	0.19200	0.190000	-2.41e-02	1.17e-02	7.49e-01
p53-Dependent G1 DNA Damage Response	55	4.24e-02	9.92e-02	0.19000	0.175000	7.33e-02	2.47e-02	3.48e-01
p53-Dependent G1/S DNA damage checkpoint	55	4.24e-02	9.92e-02	0.19000	0.175000	7.33e-02	2.47e-02	3.48e-01
Processing of DNA double-strand break ends	54	4.24e-02	9.92e-02	0.20600	-0.168000	1.18e-01	3.29e-02	1.33e-01
RNA Polymerase I Transcription Initiation	38	4.25e-02	9.92e-02	0.24400	-0.212000	1.20e-01	2.37e-02	2.00e-01
Activation of BAD and translocation to mitochondria	14	4.27e-02	9.94e-02	0.37600	0.352000	1.33e-01	2.26e-02	3.90e-01
RNA Polymerase III Transcription Initiation	33	4.29e-02	9.98e-02	0.26300	-0.165000	2.04e-01	1.01e-01	4.24e-02
activated TAK1 mediates p38 MAPK activation	13	4.33e-02	1.00e-01	0.39200	0.377000	1.08e-01	1.88e-02	5.02e-01
Hedgehog ‘off’ state	75	4.34e-02	1.01e-01	0.16600	0.165000	1.61e-02	1.37e-02	8.10e-01
Effects of PIP2 hydrolysis	19	4.39e-02	1.02e-01	0.34300	-0.297000	1.71e-01	2.49e-02	1.98e-01
Cell death signalling via NRAGE, NRIF and NADE	46	4.62e-02	1.06e-01	0.21500	0.210000	-4.61e-02	1.40e-02	5.89e-01
Signaling by Non-Receptor Tyrosine Kinases	33	4.69e-02	1.08e-01	0.24100	0.218000	1.01e-01	3.01e-02	3.15e-01
Signaling by PTK6	33	4.69e-02	1.08e-01	0.24100	0.218000	1.01e-01	3.01e-02	3.15e-01
ADP signalling through P2Y purinoceptor 12	12	4.78e-02	1.09e-01	0.39400	0.279000	2.78e-01	9.41e-02	9.59e-02
Separation of Sister Chromatids	145	4.82e-02	1.10e-01	0.11500	0.056000	1.00e-01	2.47e-01	3.85e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	32	4.83e-02	1.10e-01	0.26200	-0.205000	1.63e-01	4.50e-02	1.12e-01
Peroxisomal protein import	48	4.86e-02	1.11e-01	0.20200	0.198000	3.82e-02	1.78e-02	6.47e-01
Glycosphingolipid metabolism	27	4.88e-02	1.11e-01	0.27000	0.269000	2.55e-02	1.56e-02	8.19e-01
Nucleobase biosynthesis	10	4.92e-02	1.12e-01	0.46500	-0.250000	3.92e-01	1.72e-01	3.19e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	32	4.93e-02	1.12e-01	0.25100	0.251000	-8.18e-03	1.43e-02	9.36e-01
Gap junction trafficking and regulation	10	4.97e-02	1.12e-01	0.45200	0.446000	-6.91e-02	1.45e-02	7.05e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	14	4.98e-02	1.12e-01	0.38500	0.371000	-1.05e-01	1.63e-02	4.98e-01
Costimulation by the CD28 family	45	5.03e-02	1.13e-01	0.21400	-0.039700	2.10e-01	6.46e-01	1.50e-02
Calnexin/calreticulin cycle	23	5.04e-02	1.13e-01	0.29300	0.293000	1.07e-02	1.52e-02	9.29e-01
Generation of second messenger molecules	16	5.06e-02	1.13e-01	0.36500	-0.320000	1.74e-01	2.66e-02	2.28e-01
Inositol phosphate metabolism	29	5.07e-02	1.13e-01	0.26800	0.256000	-7.95e-02	1.73e-02	4.59e-01
Apoptotic cleavage of cellular proteins	25	5.08e-02	1.13e-01	0.27000	0.199000	1.83e-01	8.50e-02	1.14e-01
Synthesis of PC	19	5.15e-02	1.15e-01	0.31200	0.278000	1.40e-01	3.57e-02	2.92e-01
Glycogen synthesis	11	5.19e-02	1.16e-01	0.42800	0.422000	-7.17e-02	1.54e-02	6.81e-01
APC/C-mediated degradation of cell cycle proteins	77	5.25e-02	1.16e-01	0.15500	0.137000	7.23e-02	3.86e-02	2.74e-01
Regulation of mitotic cell cycle	77	5.25e-02	1.16e-01	0.15500	0.137000	7.23e-02	3.86e-02	2.74e-01
Vasopressin regulates renal water homeostasis via Aquaporins	21	5.29e-02	1.17e-01	0.29500	0.260000	1.39e-01	3.91e-02	2.72e-01
Transcription of the HIV genome	55	5.37e-02	1.19e-01	0.18700	0.017100	1.86e-01	8.27e-01	1.72e-02
Interleukin-6 family signaling	12	5.38e-02	1.19e-01	0.39500	0.385000	8.71e-02	2.10e-02	6.01e-01
Suppression of phagosomal maturation	12	5.39e-02	1.19e-01	0.39100	0.362000	1.46e-01	2.98e-02	3.82e-01
Nucleobase catabolism	21	5.48e-02	1.20e-01	0.31000	0.296000	-9.33e-02	1.89e-02	4.60e-01
Prostacyclin signalling through prostacyclin receptor	11	5.48e-02	1.20e-01	0.40300	0.229000	3.32e-01	1.89e-01	5.67e-02
Negative regulation of the PI3K/AKT network	53	5.65e-02	1.23e-01	0.18500	0.175000	6.01e-02	2.75e-02	4.50e-01
EML4 and NUDC in mitotic spindle formation	85	5.66e-02	1.23e-01	0.15300	-0.038100	1.49e-01	5.45e-01	1.82e-02
RIPK1-mediated regulated necrosis	24	5.67e-02	1.23e-01	0.28400	0.283000	-2.83e-02	1.66e-02	8.10e-01
Regulation of necroptotic cell death	24	5.67e-02	1.23e-01	0.28400	0.283000	-2.83e-02	1.66e-02	8.10e-01
Uptake and actions of bacterial toxins	19	5.82e-02	1.26e-01	0.32400	0.304000	-1.11e-01	2.18e-02	4.01e-01
Transcriptional regulation of granulopoiesis	24	5.85e-02	1.27e-01	0.29200	0.244000	-1.60e-01	3.91e-02	1.74e-01
Deposition of new CENPA-containing nucleosomes at the centromere	20	5.86e-02	1.27e-01	0.30800	-0.307000	1.09e-02	1.73e-02	9.33e-01
Nucleosome assembly	20	5.86e-02	1.27e-01	0.30800	-0.307000	1.09e-02	1.73e-02	9.33e-01
G alpha (z) signalling events	24	5.95e-02	1.28e-01	0.26900	0.219000	1.56e-01	6.29e-02	1.88e-01
Triglyceride catabolism	11	5.98e-02	1.29e-01	0.42300	0.399000	-1.41e-01	2.20e-02	4.17e-01
Transcriptional regulation of white adipocyte differentiation	55	6.07e-02	1.30e-01	0.18000	0.170000	5.76e-02	2.93e-02	4.60e-01
Unfolded Protein Response (UPR)	70	6.07e-02	1.30e-01	0.15700	0.131000	8.70e-02	5.82e-02	2.09e-01
Signaling by FLT3 fusion proteins	17	6.20e-02	1.33e-01	0.34400	0.222000	-2.62e-01	1.13e-01	6.13e-02
Intrinsic Pathway for Apoptosis	46	6.21e-02	1.33e-01	0.19500	0.183000	6.71e-02	3.16e-02	4.32e-01
Orc1 removal from chromatin	61	6.33e-02	1.35e-01	0.16700	0.089600	1.41e-01	2.27e-01	5.64e-02
GPVI-mediated activation cascade	24	6.38e-02	1.36e-01	0.26500	0.195000	1.80e-01	9.83e-02	1.28e-01
SCF(Skp2)-mediated degradation of p27/p21	52	6.42e-02	1.36e-01	0.18500	0.183000	2.76e-02	2.25e-02	7.31e-01
ERKs are inactivated	12	6.48e-02	1.37e-01	0.38300	0.376000	7.26e-02	2.42e-02	6.64e-01
Regulation of TP53 Expression and Degradation	33	6.52e-02	1.38e-01	0.23800	-0.043300	2.34e-01	6.67e-01	2.01e-02
Apoptotic execution phase	33	6.52e-02	1.38e-01	0.22900	0.220000	6.40e-02	2.87e-02	5.25e-01
FGFR1 mutant receptor activation	20	6.55e-02	1.38e-01	0.31100	0.282000	-1.30e-01	2.90e-02	3.15e-01
S Phase	138	6.59e-02	1.39e-01	0.12000	-0.063500	1.01e-01	1.99e-01	4.06e-02
Interleukin-15 signaling	12	6.61e-02	1.39e-01	0.40400	0.253000	-3.15e-01	1.29e-01	5.91e-02
Myogenesis	13	6.72e-02	1.41e-01	0.38700	0.279000	-2.68e-01	8.12e-02	9.39e-02
Intraflagellar transport	31	6.82e-02	1.42e-01	0.23300	-0.210000	-9.92e-02	4.29e-02	3.39e-01
Negative regulation of MAPK pathway	36	6.83e-02	1.42e-01	0.21400	0.165000	1.37e-01	8.76e-02	1.56e-01
RHOB GTPase cycle	44	6.84e-02	1.42e-01	0.19800	0.195000	3.77e-02	2.56e-02	6.66e-01
Interleukin-6 signaling	10	6.85e-02	1.42e-01	0.40700	0.345000	2.15e-01	5.88e-02	2.39e-01
Maturation of nucleoprotein	10	6.85e-02	1.42e-01	0.43500	-0.178000	3.97e-01	3.30e-01	2.97e-02
RHOF GTPase cycle	25	6.88e-02	1.43e-01	0.25600	0.189000	1.73e-01	1.02e-01	1.35e-01
Cell recruitment (pro-inflammatory response)	15	6.91e-02	1.43e-01	0.34200	0.341000	2.40e-02	2.23e-02	8.72e-01
Purinergic signaling in leishmaniasis infection	15	6.91e-02	1.43e-01	0.34200	0.341000	2.40e-02	2.23e-02	8.72e-01
Processive synthesis on the lagging strand	13	7.02e-02	1.45e-01	0.37500	-0.365000	8.36e-02	2.26e-02	6.02e-01
Nucleotide salvage	18	7.03e-02	1.45e-01	0.32600	0.192000	-2.63e-01	1.58e-01	5.33e-02
Defects in vitamin and cofactor metabolism	16	7.12e-02	1.46e-01	0.33900	-0.324000	1.01e-01	2.51e-02	4.83e-01
DNA Replication Pre-Initiation	72	7.16e-02	1.47e-01	0.15400	0.027300	1.52e-01	6.89e-01	2.64e-02
Protein folding	62	7.20e-02	1.47e-01	0.17000	0.169000	-1.70e-02	2.18e-02	8.17e-01
Anti-inflammatory response favouring Leishmania parasite infection	51	7.22e-02	1.47e-01	0.19200	0.166000	-9.78e-02	4.10e-02	2.28e-01
Leishmania parasite growth and survival	51	7.22e-02	1.47e-01	0.19200	0.166000	-9.78e-02	4.10e-02	2.28e-01
Josephin domain DUBs	10	7.31e-02	1.49e-01	0.41000	0.402000	8.07e-02	2.78e-02	6.59e-01
Complex I biogenesis	43	7.32e-02	1.49e-01	0.20500	0.198000	-5.37e-02	2.46e-02	5.43e-01
Gluconeogenesis	24	7.35e-02	1.49e-01	0.28000	0.227000	-1.64e-01	5.44e-02	1.65e-01
HDACs deacetylate histones	28	7.40e-02	1.50e-01	0.24100	0.216000	1.06e-01	4.82e-02	3.30e-01
RHOD GTPase cycle	37	7.44e-02	1.51e-01	0.20800	0.121000	1.69e-01	2.03e-01	7.53e-02
RHOBTB GTPase Cycle	28	7.45e-02	1.51e-01	0.24000	0.213000	1.11e-01	5.12e-02	3.11e-01
Collagen formation	27	7.49e-02	1.51e-01	0.26300	0.210000	-1.59e-01	5.96e-02	1.52e-01
Regulation of PTEN gene transcription	49	7.50e-02	1.51e-01	0.18100	0.156000	9.23e-02	5.96e-02	2.64e-01
FOXO-mediated transcription of cell death genes	14	7.52e-02	1.51e-01	0.35300	0.351000	-3.00e-02	2.29e-02	8.46e-01
Metabolism of steroid hormones	12	7.54e-02	1.51e-01	0.37500	0.374000	3.21e-02	2.50e-02	8.47e-01
Pre-NOTCH Expression and Processing	41	7.55e-02	1.51e-01	0.20700	0.205000	-2.73e-02	2.32e-02	7.63e-01
Sphingolipid de novo biosynthesis	23	7.60e-02	1.52e-01	0.28400	0.228000	-1.70e-01	5.89e-02	1.58e-01
Disorders of transmembrane transporters	105	7.65e-02	1.52e-01	0.12500	0.120000	3.64e-02	3.45e-02	5.21e-01
Mitotic Spindle Checkpoint	96	7.66e-02	1.52e-01	0.13800	-0.053800	1.27e-01	3.63e-01	3.20e-02
The NLRP3 inflammasome	12	7.66e-02	1.52e-01	0.37200	0.367000	6.06e-02	2.78e-02	7.16e-01
Signaling by FGFR4	25	7.95e-02	1.58e-01	0.25100	0.221000	1.18e-01	5.55e-02	3.08e-01
Membrane binding and targetting of GAG proteins	12	8.08e-02	1.60e-01	0.36900	0.366000	4.80e-02	2.83e-02	7.74e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	12	8.08e-02	1.60e-01	0.36900	0.366000	4.80e-02	2.83e-02	7.74e-01
Attenuation phase	19	8.13e-02	1.61e-01	0.28900	0.273000	9.37e-02	3.94e-02	4.80e-01
Pre-NOTCH Processing in Golgi	15	8.22e-02	1.62e-01	0.32300	0.300000	1.20e-01	4.44e-02	4.20e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	41	8.26e-02	1.63e-01	0.20800	0.093400	-1.86e-01	3.01e-01	3.95e-02
Switching of origins to a post-replicative state	79	8.33e-02	1.64e-01	0.14100	0.056800	1.29e-01	3.84e-01	4.85e-02
Signaling by FGFR3	26	8.34e-02	1.64e-01	0.24400	0.220000	1.07e-01	5.29e-02	3.47e-01
TGF-beta receptor signaling activates SMADs	32	8.39e-02	1.64e-01	0.23200	0.222000	-7.03e-02	3.02e-02	4.92e-01
Dopamine Neurotransmitter Release Cycle	12	8.50e-02	1.66e-01	0.36000	-0.112000	-3.42e-01	5.03e-01	4.00e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	38	8.59e-02	1.66e-01	0.20100	0.187000	7.57e-02	4.66e-02	4.20e-01
HIV Transcription Initiation	37	8.62e-02	1.66e-01	0.20200	0.111000	1.69e-01	2.43e-01	7.54e-02
RNA Polymerase II HIV Promoter Escape	37	8.62e-02	1.66e-01	0.20200	0.111000	1.69e-01	2.43e-01	7.54e-02
RNA Polymerase II Promoter Escape	37	8.62e-02	1.66e-01	0.20200	0.111000	1.69e-01	2.43e-01	7.54e-02
RNA Polymerase II Transcription Initiation	37	8.62e-02	1.66e-01	0.20200	0.111000	1.69e-01	2.43e-01	7.54e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	37	8.62e-02	1.66e-01	0.20200	0.111000	1.69e-01	2.43e-01	7.54e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	37	8.62e-02	1.66e-01	0.20200	0.111000	1.69e-01	2.43e-01	7.54e-02
Synthesis of DNA	103	8.62e-02	1.66e-01	0.13000	-0.055300	1.18e-01	3.33e-01	3.89e-02
PRC2 methylates histones and DNA	11	8.62e-02	1.66e-01	0.39500	-0.372000	1.33e-01	3.28e-02	4.45e-01
Aquaporin-mediated transport	22	8.67e-02	1.67e-01	0.26400	0.244000	1.01e-01	4.79e-02	4.11e-01
VxPx cargo-targeting to cilium	16	8.67e-02	1.67e-01	0.31300	0.305000	6.97e-02	3.48e-02	6.30e-01
Condensation of Prophase Chromosomes	11	8.76e-02	1.68e-01	0.36800	-0.288000	-2.30e-01	9.84e-02	1.87e-01
Host Interactions of HIV factors	106	8.77e-02	1.68e-01	0.12200	0.026700	1.19e-01	6.36e-01	3.50e-02
DNA Replication	110	8.85e-02	1.69e-01	0.12500	-0.041900	1.18e-01	4.49e-01	3.37e-02
Sema4D in semaphorin signaling	15	8.86e-02	1.69e-01	0.32400	0.320000	4.53e-02	3.17e-02	7.62e-01
Dual Incision in GG-NER	35	9.01e-02	1.72e-01	0.21700	-0.214000	3.38e-02	2.87e-02	7.29e-01
RHO GTPases Activate Formins	100	9.13e-02	1.74e-01	0.12800	-0.017300	1.27e-01	7.66e-01	2.89e-02
Muscle contraction	63	9.20e-02	1.75e-01	0.16600	0.111000	-1.23e-01	1.27e-01	9.22e-02
Meiosis	38	9.21e-02	1.75e-01	0.21000	-0.197000	7.13e-02	3.54e-02	4.48e-01
Signaling by TGF-beta Receptor Complex	63	9.29e-02	1.76e-01	0.16400	0.145000	-7.82e-02	4.75e-02	2.84e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	35	9.39e-02	1.77e-01	0.21400	-0.025800	2.13e-01	7.92e-01	2.97e-02
HIV Transcription Elongation	35	9.39e-02	1.77e-01	0.21400	-0.025800	2.13e-01	7.92e-01	2.97e-02
Tat-mediated elongation of the HIV-1 transcript	35	9.39e-02	1.77e-01	0.21400	-0.025800	2.13e-01	7.92e-01	2.97e-02
G alpha (q) signalling events	72	9.43e-02	1.77e-01	0.14300	0.120000	7.73e-02	7.93e-02	2.58e-01
Regulation of TP53 Degradation	32	9.51e-02	1.79e-01	0.22300	-0.026000	2.22e-01	8.00e-01	3.02e-02
Regulation of insulin secretion	38	9.59e-02	1.80e-01	0.20500	0.203000	-2.38e-02	3.04e-02	8.00e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	12	9.69e-02	1.81e-01	0.36100	0.360000	-2.70e-02	3.07e-02	8.71e-01
ADP signalling through P2Y purinoceptor 1	15	9.91e-02	1.85e-01	0.32200	0.321000	-3.19e-02	3.16e-02	8.31e-01
G beta:gamma signalling through CDC42	12	9.93e-02	1.85e-01	0.34400	0.276000	2.05e-01	9.79e-02	2.19e-01
Syndecan interactions	10	9.99e-02	1.86e-01	0.37600	0.302000	2.24e-01	9.81e-02	2.20e-01
Inflammasomes	16	1.00e-01	1.86e-01	0.30200	0.289000	8.75e-02	4.54e-02	5.45e-01
PKA activation	10	1.03e-01	1.92e-01	0.40500	0.264000	-3.07e-01	1.48e-01	9.30e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	81	1.04e-01	1.93e-01	0.14100	-0.058200	1.28e-01	3.66e-01	4.63e-02
Amplification of signal from the kinetochores	81	1.04e-01	1.93e-01	0.14100	-0.058200	1.28e-01	3.66e-01	4.63e-02
Signaling by cytosolic FGFR1 fusion mutants	17	1.05e-01	1.95e-01	0.30800	0.261000	-1.64e-01	6.27e-02	2.42e-01
Sialic acid metabolism	23	1.07e-01	1.97e-01	0.25400	0.254000	3.26e-03	3.52e-02	9.78e-01
Factors involved in megakaryocyte development and platelet production	86	1.07e-01	1.98e-01	0.13200	0.132000	1.26e-03	3.55e-02	9.84e-01
Response of EIF2AK1 (HRI) to heme deficiency	13	1.10e-01	2.01e-01	0.32600	0.302000	1.23e-01	5.93e-02	4.41e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	23	1.10e-01	2.02e-01	0.25400	-0.253000	1.65e-02	3.56e-02	8.91e-01
FLT3 signaling in disease	25	1.11e-01	2.03e-01	0.24700	0.239000	-5.99e-02	3.85e-02	6.05e-01
Sema3A PAK dependent Axon repulsion	11	1.11e-01	2.03e-01	0.36900	0.364000	-5.52e-02	3.64e-02	7.52e-01
mRNA Splicing	151	1.11e-01	2.03e-01	0.09990	-0.011400	9.93e-02	8.10e-01	3.61e-02
RNA Polymerase I Promoter Clearance	41	1.11e-01	2.03e-01	0.19700	-0.147000	1.31e-01	1.03e-01	1.48e-01
RNA Polymerase I Transcription	41	1.11e-01	2.03e-01	0.19700	-0.147000	1.31e-01	1.03e-01	1.48e-01
Cyclin E associated events during G1/S transition	72	1.11e-01	2.03e-01	0.14000	0.138000	2.64e-02	4.34e-02	6.99e-01
Translesion synthesis by REV1	14	1.14e-01	2.07e-01	0.33400	-0.268000	2.00e-01	8.26e-02	1.95e-01
RND3 GTPase cycle	28	1.16e-01	2.10e-01	0.23500	0.122000	-2.01e-01	2.65e-01	6.63e-02
Mitotic Prometaphase	154	1.16e-01	2.10e-01	0.10100	-0.058500	8.24e-02	2.12e-01	7.90e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	10	1.17e-01	2.11e-01	0.39300	-0.220000	3.25e-01	2.28e-01	7.50e-02
Aggrephagy	18	1.17e-01	2.11e-01	0.27100	0.226000	1.49e-01	9.70e-02	2.73e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	46	1.18e-01	2.12e-01	0.17800	0.176000	-2.12e-02	3.87e-02	8.04e-01
Ub-specific processing proteases	131	1.19e-01	2.14e-01	0.10100	0.084500	5.48e-02	9.62e-02	2.81e-01
O-linked glycosylation of mucins	26	1.19e-01	2.14e-01	0.24300	0.165000	-1.79e-01	1.45e-01	1.15e-01
Signaling by ERBB4	31	1.20e-01	2.14e-01	0.21700	0.212000	-5.01e-02	4.16e-02	6.30e-01
Gastrin-CREB signalling pathway via PKC and MAPK	12	1.20e-01	2.15e-01	0.34900	0.338000	-8.61e-02	4.24e-02	6.06e-01
NGF-stimulated transcription	25	1.20e-01	2.15e-01	0.23000	0.206000	1.02e-01	7.53e-02	3.77e-01
Removal of the Flap Intermediate	12	1.22e-01	2.18e-01	0.35100	-0.326000	1.29e-01	5.04e-02	4.40e-01
Sensory processing of sound by outer hair cells of the cochlea	16	1.23e-01	2.20e-01	0.30800	-0.227000	2.08e-01	1.17e-01	1.50e-01
Polymerase switching on the C-strand of the telomere	22	1.24e-01	2.20e-01	0.25600	-0.248000	6.32e-02	4.39e-02	6.08e-01
Interleukin-12 signaling	35	1.26e-01	2.24e-01	0.19100	0.124000	1.45e-01	2.06e-01	1.38e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	11	1.27e-01	2.25e-01	0.36600	0.316000	-1.86e-01	7.00e-02	2.85e-01
Formation of the Early Elongation Complex	29	1.27e-01	2.25e-01	0.21400	0.042600	2.10e-01	6.91e-01	5.09e-02
Formation of the HIV-1 Early Elongation Complex	29	1.27e-01	2.25e-01	0.21400	0.042600	2.10e-01	6.91e-01	5.09e-02
HSF1-dependent transactivation	25	1.29e-01	2.28e-01	0.22400	0.155000	1.62e-01	1.81e-01	1.61e-01
ER Quality Control Compartment (ERQC)	18	1.31e-01	2.30e-01	0.27000	0.265000	4.95e-02	5.15e-02	7.16e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	30	1.31e-01	2.31e-01	0.21600	0.211000	-4.48e-02	4.56e-02	6.72e-01
S33 mutants of beta-catenin aren’t phosphorylated	13	1.33e-01	2.32e-01	0.31300	0.294000	1.05e-01	6.61e-02	5.12e-01
S37 mutants of beta-catenin aren’t phosphorylated	13	1.33e-01	2.32e-01	0.31300	0.294000	1.05e-01	6.61e-02	5.12e-01
S45 mutants of beta-catenin aren’t phosphorylated	13	1.33e-01	2.32e-01	0.31300	0.294000	1.05e-01	6.61e-02	5.12e-01
Signaling by CTNNB1 phospho-site mutants	13	1.33e-01	2.32e-01	0.31300	0.294000	1.05e-01	6.61e-02	5.12e-01
Signaling by GSK3beta mutants	13	1.33e-01	2.32e-01	0.31300	0.294000	1.05e-01	6.61e-02	5.12e-01
T41 mutants of beta-catenin aren’t phosphorylated	13	1.33e-01	2.32e-01	0.31300	0.294000	1.05e-01	6.61e-02	5.12e-01
RNA Polymerase II Pre-transcription Events	65	1.33e-01	2.32e-01	0.13900	0.060300	1.26e-01	4.02e-01	8.02e-02
Signaling by SCF-KIT	33	1.33e-01	2.32e-01	0.19900	0.196000	3.34e-02	5.17e-02	7.40e-01
Mitotic Prophase	73	1.34e-01	2.32e-01	0.13700	-0.018900	1.36e-01	7.81e-01	4.52e-02
HCMV Infection	71	1.34e-01	2.32e-01	0.13600	0.019000	1.35e-01	7.83e-01	5.04e-02
mRNA Splicing - Minor Pathway	44	1.37e-01	2.37e-01	0.17400	-0.010400	1.74e-01	9.05e-01	4.61e-02
G2/M Checkpoints	116	1.37e-01	2.37e-01	0.10900	-0.016700	1.07e-01	7.57e-01	4.67e-02
RHOBTB2 GTPase cycle	19	1.37e-01	2.37e-01	0.25400	0.132000	2.17e-01	3.20e-01	1.01e-01
Resolution of D-Loop Structures	27	1.37e-01	2.37e-01	0.22400	-0.221000	3.32e-02	4.68e-02	7.65e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	26	1.39e-01	2.39e-01	0.23000	-0.221000	6.41e-02	5.17e-02	5.72e-01
Ephrin signaling	12	1.39e-01	2.40e-01	0.34200	0.168000	-2.98e-01	3.15e-01	7.36e-02
Peptide hormone metabolism	26	1.40e-01	2.40e-01	0.22400	0.224000	3.18e-03	4.82e-02	9.78e-01
Resolution of Sister Chromatid Cohesion	90	1.40e-01	2.40e-01	0.12500	-0.047000	1.15e-01	4.42e-01	5.92e-02
Termination of translesion DNA synthesis	28	1.41e-01	2.42e-01	0.20800	-0.182000	-1.01e-01	9.51e-02	3.58e-01
mRNA decay by 3’ to 5’ exoribonuclease	14	1.42e-01	2.43e-01	0.31700	-0.217000	2.32e-01	1.60e-01	1.33e-01
G2/M DNA damage checkpoint	53	1.43e-01	2.44e-01	0.16200	-0.147000	6.81e-02	6.54e-02	3.92e-01
Signaling by FGFR1 in disease	25	1.43e-01	2.44e-01	0.23700	0.179000	-1.56e-01	1.22e-01	1.78e-01
Negative epigenetic regulation of rRNA expression	40	1.45e-01	2.46e-01	0.18500	-0.066900	1.72e-01	4.64e-01	6.01e-02
RNA Polymerase III Chain Elongation	16	1.45e-01	2.46e-01	0.29600	-0.213000	2.05e-01	1.40e-01	1.56e-01
GAB1 signalosome	10	1.45e-01	2.47e-01	0.35900	0.359000	-1.99e-02	4.96e-02	9.13e-01
G beta:gamma signalling through BTK	10	1.47e-01	2.49e-01	0.34400	0.171000	2.99e-01	3.50e-01	1.02e-01
Regulation of signaling by CBL	14	1.48e-01	2.50e-01	0.29100	0.144000	2.53e-01	3.50e-01	1.02e-01
NoRC negatively regulates rRNA expression	39	1.48e-01	2.50e-01	0.18600	-0.063000	1.74e-01	4.96e-01	5.97e-02
Senescence-Associated Secretory Phenotype (SASP)	41	1.48e-01	2.50e-01	0.16900	0.094900	1.40e-01	2.94e-01	1.20e-01
G1/S Transition	113	1.51e-01	2.54e-01	0.10800	-0.020700	1.06e-01	7.05e-01	5.32e-02
Cyclin A:Cdk2-associated events at S phase entry	74	1.52e-01	2.55e-01	0.12700	0.120000	4.21e-02	7.50e-02	5.32e-01
Carboxyterminal post-translational modifications of tubulin	22	1.52e-01	2.56e-01	0.24400	0.233000	-7.47e-02	5.92e-02	5.45e-01
G-protein activation	12	1.52e-01	2.56e-01	0.31600	0.304000	8.47e-02	6.83e-02	6.11e-01
Interleukin-12 family signaling	41	1.54e-01	2.58e-01	0.16700	0.113000	1.23e-01	2.11e-01	1.72e-01
Depolymerisation of the Nuclear Lamina	13	1.55e-01	2.60e-01	0.29900	0.271000	1.26e-01	9.11e-02	4.31e-01
RMTs methylate histone arginines	25	1.55e-01	2.60e-01	0.23200	-0.155000	1.73e-01	1.80e-01	1.35e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	18	1.56e-01	2.61e-01	0.25300	0.226000	1.15e-01	9.77e-02	4.00e-01
Cytochrome c-mediated apoptotic response	10	1.57e-01	2.61e-01	0.33900	0.296000	1.64e-01	1.05e-01	3.68e-01
Retinoid metabolism and transport	10	1.57e-01	2.61e-01	0.35100	0.351000	-1.19e-02	5.46e-02	9.48e-01
RUNX2 regulates bone development	17	1.57e-01	2.61e-01	0.27600	0.098300	-2.58e-01	4.83e-01	6.54e-02
ADORA2B mediated anti-inflammatory cytokines production	30	1.58e-01	2.62e-01	0.20400	0.203000	-1.84e-02	5.47e-02	8.62e-01
Cilium Assembly	147	1.58e-01	2.62e-01	0.09200	-0.092000	1.54e-03	5.53e-02	9.74e-01
Translesion synthesis by POLI	15	1.59e-01	2.62e-01	0.29700	-0.240000	1.76e-01	1.08e-01	2.39e-01
RNA polymerase II transcribes snRNA genes	63	1.61e-01	2.65e-01	0.13400	0.085000	1.03e-01	2.44e-01	1.57e-01
Role of LAT2/NTAL/LAB on calcium mobilization	11	1.62e-01	2.67e-01	0.33700	0.329000	-7.64e-02	5.92e-02	6.61e-01
Diseases associated with glycosylation precursor biosynthesis	18	1.63e-01	2.69e-01	0.26500	0.252000	-8.35e-02	6.48e-02	5.40e-01
Regulation of TP53 Activity through Phosphorylation	76	1.64e-01	2.69e-01	0.13200	-0.103000	8.23e-02	1.23e-01	2.16e-01
G beta:gamma signalling through PLC beta	12	1.64e-01	2.69e-01	0.30500	0.255000	1.66e-01	1.26e-01	3.20e-01
Presynaptic function of Kainate receptors	12	1.64e-01	2.69e-01	0.30500	0.255000	1.66e-01	1.26e-01	3.20e-01
PKA-mediated phosphorylation of CREB	11	1.64e-01	2.69e-01	0.34500	0.236000	-2.51e-01	1.75e-01	1.50e-01
mRNA Splicing - Major Pathway	144	1.65e-01	2.69e-01	0.09300	-0.015200	9.17e-02	7.54e-01	5.85e-02
G alpha (12/13) signalling events	40	1.65e-01	2.69e-01	0.17200	0.172000	9.45e-03	6.01e-02	9.18e-01
Formation of HIV elongation complex in the absence of HIV Tat	36	1.66e-01	2.71e-01	0.18300	-0.018100	1.83e-01	8.51e-01	5.83e-02
Signaling by Erythropoietin	20	1.67e-01	2.71e-01	0.24500	0.244000	-1.09e-02	5.85e-02	9.33e-01
Mitotic G2-G2/M phases	156	1.67e-01	2.72e-01	0.08580	0.081600	2.65e-02	8.02e-02	5.69e-01
Erythropoietin activates RAS	11	1.68e-01	2.73e-01	0.33700	0.318000	-1.12e-01	6.81e-02	5.22e-01
Thromboxane signalling through TP receptor	14	1.70e-01	2.76e-01	0.28800	0.287000	2.15e-02	6.32e-02	8.89e-01
Glycogen storage diseases	10	1.75e-01	2.82e-01	0.35400	0.288000	-2.07e-01	1.15e-01	2.57e-01
Sema4D induced cell migration and growth-cone collapse	12	1.75e-01	2.82e-01	0.31200	0.311000	-1.71e-02	6.20e-02	9.18e-01
RHOBTB1 GTPase cycle	18	1.75e-01	2.82e-01	0.24800	0.237000	7.17e-02	8.17e-02	5.99e-01
Metabolic disorders of biological oxidation enzymes	14	1.75e-01	2.82e-01	0.28400	-0.044100	-2.80e-01	7.75e-01	6.97e-02
Pausing and recovery of Tat-mediated HIV elongation	25	1.75e-01	2.82e-01	0.21400	0.006700	2.14e-01	9.54e-01	6.38e-02
Tat-mediated HIV elongation arrest and recovery	25	1.75e-01	2.82e-01	0.21400	0.006700	2.14e-01	9.54e-01	6.38e-02
Synthesis of IP3 and IP4 in the cytosol	15	1.76e-01	2.82e-01	0.28700	0.252000	-1.37e-01	9.06e-02	3.57e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	14	1.76e-01	2.82e-01	0.29900	0.246000	-1.70e-01	1.12e-01	2.71e-01
GABA receptor activation	18	1.77e-01	2.84e-01	0.24600	0.230000	8.68e-02	9.14e-02	5.24e-01
Translation of structural proteins	26	1.78e-01	2.84e-01	0.20600	0.056900	1.97e-01	6.16e-01	8.16e-02
Leading Strand Synthesis	12	1.79e-01	2.86e-01	0.31800	-0.290000	1.32e-01	8.26e-02	4.28e-01
Polymerase switching	12	1.79e-01	2.86e-01	0.31800	-0.290000	1.32e-01	8.26e-02	4.28e-01
Estrogen-dependent gene expression	68	1.82e-01	2.90e-01	0.12500	0.062700	1.08e-01	3.72e-01	1.24e-01
Mitotic G1 phase and G1/S transition	127	1.82e-01	2.90e-01	0.09480	0.000379	9.48e-02	9.94e-01	6.60e-02
RNA Polymerase I Promoter Escape	24	1.82e-01	2.90e-01	0.22600	-0.171000	1.49e-01	1.48e-01	2.08e-01
RNA Polymerase III Abortive And Retractive Initiation	37	1.85e-01	2.93e-01	0.18100	-0.091300	1.56e-01	3.37e-01	1.01e-01
RNA Polymerase III Transcription	37	1.85e-01	2.93e-01	0.18100	-0.091300	1.56e-01	3.37e-01	1.01e-01
Downregulation of ERBB2 signaling	15	1.86e-01	2.94e-01	0.26600	0.250000	8.96e-02	9.35e-02	5.48e-01
Regulation of TP53 Activity through Acetylation	26	1.87e-01	2.95e-01	0.21600	-0.161000	1.44e-01	1.55e-01	2.05e-01
Signaling by FGFR in disease	39	1.87e-01	2.95e-01	0.17600	0.141000	-1.06e-01	1.29e-01	2.52e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	1.89e-01	2.97e-01	0.26700	-0.054600	2.62e-01	7.05e-01	6.99e-02
Signaling by FGFR1	28	1.90e-01	2.99e-01	0.19200	0.168000	9.19e-02	1.24e-01	4.00e-01
Organelle biogenesis and maintenance	197	1.91e-01	2.99e-01	0.07470	-0.074200	-8.49e-03	7.42e-02	8.38e-01
Cyclin A/B1/B2 associated events during G2/M transition	22	1.91e-01	2.99e-01	0.21700	0.090000	1.97e-01	4.65e-01	1.10e-01
Triglyceride metabolism	16	1.91e-01	2.99e-01	0.27200	0.237000	-1.32e-01	1.00e-01	3.60e-01
Cytosolic sensors of pathogen-associated DNA	51	1.92e-01	3.00e-01	0.14500	0.021700	1.43e-01	7.89e-01	7.68e-02
Oncogene Induced Senescence	30	1.95e-01	3.04e-01	0.18700	0.183000	3.80e-02	8.24e-02	7.19e-01
Meiotic recombination	16	1.95e-01	3.04e-01	0.26100	-0.261000	7.57e-03	7.11e-02	9.58e-01
Metabolism of amino acids and derivatives	219	1.95e-01	3.04e-01	0.07090	0.002310	7.09e-02	9.53e-01	7.26e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation	14	1.96e-01	3.05e-01	0.28400	0.274000	-7.69e-02	7.65e-02	6.19e-01
Post-chaperonin tubulin folding pathway	13	1.99e-01	3.08e-01	0.29500	0.277000	-1.03e-01	8.41e-02	5.21e-01
Metabolism of fat-soluble vitamins	12	2.02e-01	3.13e-01	0.29200	0.283000	7.19e-02	9.01e-02	6.66e-01
Metal ion SLC transporters	15	2.02e-01	3.13e-01	0.27700	0.169000	-2.20e-01	2.59e-01	1.40e-01
Signaling by Hippo	12	2.04e-01	3.15e-01	0.29700	0.297000	-7.10e-03	7.52e-02	9.66e-01
APC truncation mutants have impaired AXIN binding	12	2.05e-01	3.15e-01	0.28800	0.268000	1.06e-01	1.09e-01	5.25e-01
AXIN missense mutants destabilize the destruction complex	12	2.05e-01	3.15e-01	0.28800	0.268000	1.06e-01	1.09e-01	5.25e-01
Signaling by AMER1 mutants	12	2.05e-01	3.15e-01	0.28800	0.268000	1.06e-01	1.09e-01	5.25e-01
Signaling by APC mutants	12	2.05e-01	3.15e-01	0.28800	0.268000	1.06e-01	1.09e-01	5.25e-01
Signaling by AXIN mutants	12	2.05e-01	3.15e-01	0.28800	0.268000	1.06e-01	1.09e-01	5.25e-01
Truncations of AMER1 destabilize the destruction complex	12	2.05e-01	3.15e-01	0.28800	0.268000	1.06e-01	1.09e-01	5.25e-01
TP53 Regulates Transcription of Cell Death Genes	30	2.06e-01	3.16e-01	0.19400	0.166000	-1.01e-01	1.16e-01	3.37e-01
Processive synthesis on the C-strand of the telomere	17	2.07e-01	3.17e-01	0.24400	-0.238000	-5.17e-02	8.91e-02	7.12e-01
Pyroptosis	18	2.08e-01	3.18e-01	0.24400	0.241000	-3.82e-02	7.73e-02	7.79e-01
Reproduction	43	2.09e-01	3.19e-01	0.16000	-0.151000	5.29e-02	8.75e-02	5.49e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	23	2.09e-01	3.19e-01	0.21300	-0.213000	9.17e-03	7.72e-02	9.39e-01
Sulfur amino acid metabolism	15	2.11e-01	3.21e-01	0.26700	-0.058600	2.61e-01	6.94e-01	8.05e-02
Glutamate Neurotransmitter Release Cycle	11	2.14e-01	3.25e-01	0.30300	-0.025700	-3.02e-01	8.83e-01	8.33e-02
Protein-protein interactions at synapses	31	2.14e-01	3.25e-01	0.18200	0.006060	-1.82e-01	9.53e-01	7.95e-02
Translation of Replicase and Assembly of the Replication Transcription Complex	10	2.16e-01	3.28e-01	0.31900	0.319000	-3.66e-04	8.11e-02	9.98e-01
Nuclear signaling by ERBB4	16	2.16e-01	3.28e-01	0.25900	0.244000	-8.70e-02	9.16e-02	5.47e-01
Recognition of DNA damage by PCNA-containing replication complex	26	2.18e-01	3.31e-01	0.20000	-0.196000	3.96e-02	8.32e-02	7.27e-01
TICAM1, RIP1-mediated IKK complex recruitment	17	2.21e-01	3.33e-01	0.23900	0.233000	5.14e-02	9.63e-02	7.14e-01
Regulation of beta-cell development	14	2.21e-01	3.33e-01	0.27900	0.230000	-1.58e-01	1.37e-01	3.07e-01
Glucagon-type ligand receptors	13	2.21e-01	3.34e-01	0.27000	0.091500	2.54e-01	5.68e-01	1.13e-01
Ca-dependent events	21	2.23e-01	3.35e-01	0.21700	0.216000	1.23e-02	8.62e-02	9.22e-01
G2/M Transition	154	2.24e-01	3.36e-01	0.07890	0.074300	2.64e-02	1.13e-01	5.74e-01
Assembly and cell surface presentation of NMDA receptors	11	2.25e-01	3.38e-01	0.28900	-0.163000	-2.38e-01	3.49e-01	1.72e-01
HSF1 activation	21	2.26e-01	3.38e-01	0.20800	0.161000	1.32e-01	2.01e-01	2.96e-01
Diseases associated with N-glycosylation of proteins	15	2.26e-01	3.38e-01	0.25000	0.088600	2.33e-01	5.53e-01	1.18e-01
IKK complex recruitment mediated by RIP1	17	2.29e-01	3.42e-01	0.23500	0.229000	5.66e-02	1.03e-01	6.87e-01
FOXO-mediated transcription	46	2.29e-01	3.42e-01	0.14600	0.146000	2.72e-04	8.71e-02	9.97e-01
CD28 co-stimulation	27	2.30e-01	3.43e-01	0.19300	-0.032700	1.90e-01	7.69e-01	8.76e-02
Pre-NOTCH Transcription and Translation	27	2.34e-01	3.49e-01	0.19700	0.142000	-1.37e-01	2.01e-01	2.19e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	10	2.34e-01	3.49e-01	0.31500	0.062800	-3.09e-01	7.31e-01	9.08e-02
Neurexins and neuroligins	19	2.35e-01	3.49e-01	0.21800	-0.102000	-1.92e-01	4.44e-01	1.47e-01
Initiation of Nuclear Envelope (NE) Reformation	17	2.38e-01	3.54e-01	0.23100	0.222000	6.43e-02	1.13e-01	6.46e-01
Cell junction organization	25	2.39e-01	3.54e-01	0.19600	0.196000	-1.69e-02	9.07e-02	8.84e-01
Regulation of pyruvate dehydrogenase (PDH) complex	11	2.39e-01	3.54e-01	0.29500	-0.021000	2.95e-01	9.04e-01	9.07e-02
Biological oxidations	77	2.39e-01	3.54e-01	0.11300	0.014100	-1.12e-01	8.31e-01	9.12e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	2.40e-01	3.55e-01	0.24800	-0.057200	2.41e-01	6.92e-01	9.50e-02
PKMTs methylate histone lysines	30	2.41e-01	3.55e-01	0.18500	-0.121000	1.41e-01	2.52e-01	1.83e-01
HCMV Late Events	51	2.42e-01	3.57e-01	0.13500	0.008140	1.35e-01	9.20e-01	9.56e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	2.45e-01	3.60e-01	0.28700	-0.269000	9.84e-02	1.07e-01	5.55e-01
Metabolism of nucleotides	68	2.46e-01	3.61e-01	0.12100	0.108000	-5.53e-02	1.24e-01	4.31e-01
Caspase activation via extrinsic apoptotic signalling pathway	15	2.46e-01	3.61e-01	0.24900	0.248000	4.46e-03	9.58e-02	9.76e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	2.47e-01	3.62e-01	0.26400	0.261000	3.74e-02	1.03e-01	8.15e-01
Diseases of programmed cell death	35	2.54e-01	3.71e-01	0.15600	0.138000	7.36e-02	1.59e-01	4.52e-01
ZBP1(DAI) mediated induction of type I IFNs	17	2.54e-01	3.71e-01	0.22200	0.149000	1.65e-01	2.87e-01	2.40e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	25	2.55e-01	3.72e-01	0.19900	-0.127000	1.53e-01	2.72e-01	1.86e-01
Activation of NMDA receptors and postsynaptic events	42	2.57e-01	3.74e-01	0.15300	0.121000	-9.37e-02	1.75e-01	2.94e-01
TNFR1-induced proapoptotic signaling	11	2.58e-01	3.75e-01	0.27700	-0.254000	-1.11e-01	1.44e-01	5.24e-01
N-glycan antennae elongation in the medial/trans-Golgi	17	2.60e-01	3.78e-01	0.22700	-0.026600	-2.26e-01	8.49e-01	1.07e-01
Translesion synthesis by POLK	15	2.61e-01	3.79e-01	0.25300	-0.217000	1.30e-01	1.46e-01	3.82e-01
RNA Polymerase I Transcription Termination	23	2.62e-01	3.81e-01	0.20500	-0.158000	1.31e-01	1.91e-01	2.77e-01
NRAGE signals death through JNK	31	2.65e-01	3.84e-01	0.16800	0.168000	7.79e-03	1.06e-01	9.40e-01
FCGR3A-mediated IL10 synthesis	22	2.67e-01	3.87e-01	0.20100	0.023200	-2.00e-01	8.50e-01	1.04e-01
CTLA4 inhibitory signaling	16	2.68e-01	3.88e-01	0.23900	-0.065300	2.30e-01	6.51e-01	1.12e-01
Constitutive Signaling by Aberrant PI3K in Cancer	26	2.69e-01	3.88e-01	0.17600	0.125000	1.24e-01	2.70e-01	2.75e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	13	2.70e-01	3.89e-01	0.25900	0.259000	-1.11e-02	1.06e-01	9.45e-01
Intra-Golgi traffic	39	2.70e-01	3.89e-01	0.15200	0.149000	-2.79e-02	1.08e-01	7.64e-01
Activation of gene expression by SREBF (SREBP)	34	2.75e-01	3.96e-01	0.16300	0.154000	-5.26e-02	1.20e-01	5.96e-01
BBSome-mediated cargo-targeting to cilium	19	2.76e-01	3.97e-01	0.20500	-0.184000	-9.12e-02	1.65e-01	4.92e-01
Telomere C-strand synthesis initiation	10	2.81e-01	4.03e-01	0.30000	-0.270000	1.31e-01	1.39e-01	4.73e-01
Transcriptional Regulation by E2F6	29	2.85e-01	4.08e-01	0.16700	-0.165000	-2.74e-02	1.24e-01	7.98e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	22	2.85e-01	4.08e-01	0.19800	0.037500	-1.94e-01	7.61e-01	1.15e-01
Signaling by FGFR2	47	2.89e-01	4.12e-01	0.12800	0.113000	6.13e-02	1.82e-01	4.68e-01
RUNX2 regulates osteoblast differentiation	12	2.91e-01	4.15e-01	0.26200	0.006000	-2.62e-01	9.71e-01	1.17e-01
Trafficking and processing of endosomal TLR	10	2.93e-01	4.17e-01	0.29800	0.194000	-2.26e-01	2.88e-01	2.16e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	10	2.93e-01	4.17e-01	0.29600	-0.259000	1.42e-01	1.56e-01	4.36e-01
MET promotes cell motility	13	2.93e-01	4.17e-01	0.24400	0.228000	8.66e-02	1.55e-01	5.89e-01
PINK1-PRKN Mediated Mitophagy	18	2.95e-01	4.19e-01	0.20500	0.179000	1.01e-01	1.90e-01	4.61e-01
Other interleukin signaling	15	3.00e-01	4.26e-01	0.23300	0.028900	-2.31e-01	8.46e-01	1.21e-01
MicroRNA (miRNA) biogenesis	20	3.02e-01	4.27e-01	0.20100	-0.021400	2.00e-01	8.68e-01	1.22e-01
HIV elongation arrest and recovery	26	3.02e-01	4.27e-01	0.17400	0.016100	1.73e-01	8.87e-01	1.27e-01
Pausing and recovery of HIV elongation	26	3.02e-01	4.27e-01	0.17400	0.016100	1.73e-01	8.87e-01	1.27e-01
The role of Nef in HIV-1 replication and disease pathogenesis	19	3.03e-01	4.28e-01	0.20600	0.205000	-2.35e-02	1.22e-01	8.60e-01
Transcriptional Regulation by TP53	296	3.03e-01	4.28e-01	0.05170	0.010500	5.06e-02	7.57e-01	1.38e-01
Apoptotic factor-mediated response	15	3.04e-01	4.28e-01	0.22900	0.229000	3.37e-03	1.25e-01	9.82e-01
Ion transport by P-type ATPases	27	3.05e-01	4.28e-01	0.17000	0.011800	1.70e-01	9.16e-01	1.27e-01
Insulin receptor signalling cascade	26	3.05e-01	4.28e-01	0.16900	0.152000	7.41e-02	1.81e-01	5.13e-01
Transport of vitamins, nucleosides, and related molecules	21	3.07e-01	4.30e-01	0.19600	0.036500	-1.93e-01	7.72e-01	1.26e-01
Class I peroxisomal membrane protein import	19	3.07e-01	4.30e-01	0.20600	-0.202000	4.13e-02	1.27e-01	7.55e-01
Peroxisomal lipid metabolism	22	3.07e-01	4.30e-01	0.19100	0.189000	-3.25e-02	1.26e-01	7.92e-01
Zinc transporters	11	3.12e-01	4.36e-01	0.27500	0.133000	-2.41e-01	4.46e-01	1.67e-01
Citric acid cycle (TCA cycle)	19	3.20e-01	4.47e-01	0.19300	0.176000	8.11e-02	1.86e-01	5.41e-01
Cell-Cell communication	47	3.22e-01	4.49e-01	0.12600	0.125000	1.24e-02	1.38e-01	8.84e-01
Activation of BH3-only proteins	27	3.22e-01	4.49e-01	0.16100	0.138000	8.35e-02	2.16e-01	4.53e-01
RAF-independent MAPK1/3 activation	20	3.23e-01	4.49e-01	0.18700	0.165000	8.79e-02	2.01e-01	4.96e-01
Activation of GABAB receptors	17	3.26e-01	4.53e-01	0.20300	0.188000	7.64e-02	1.79e-01	5.86e-01
GABA B receptor activation	17	3.26e-01	4.53e-01	0.20300	0.188000	7.64e-02	1.79e-01	5.86e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	15	3.30e-01	4.57e-01	0.21800	0.215000	3.78e-02	1.49e-01	8.00e-01
Pyruvate metabolism	20	3.30e-01	4.57e-01	0.18600	0.167000	8.23e-02	1.98e-01	5.25e-01
TRAF6 mediated NF-kB activation	18	3.32e-01	4.59e-01	0.20800	0.189000	-8.80e-02	1.66e-01	5.18e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	61	3.32e-01	4.59e-01	0.10600	0.094800	4.79e-02	2.01e-01	5.19e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	10	3.33e-01	4.59e-01	0.26000	0.210000	1.53e-01	2.50e-01	4.03e-01
SHC1 events in ERBB2 signaling	11	3.36e-01	4.63e-01	0.26800	0.186000	-1.93e-01	2.85e-01	2.69e-01
ECM proteoglycans	12	3.37e-01	4.64e-01	0.24000	-0.232000	-6.26e-02	1.65e-01	7.08e-01
CaM pathway	20	3.39e-01	4.65e-01	0.19200	0.190000	-3.00e-02	1.42e-01	8.16e-01
Calmodulin induced events	20	3.39e-01	4.65e-01	0.19200	0.190000	-3.00e-02	1.42e-01	8.16e-01
Post NMDA receptor activation events	37	3.39e-01	4.65e-01	0.14200	0.139000	-2.73e-02	1.44e-01	7.74e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	13	3.42e-01	4.68e-01	0.22900	0.067400	2.19e-01	6.74e-01	1.73e-01
Mitophagy	23	3.52e-01	4.81e-01	0.17400	0.174000	-4.53e-03	1.49e-01	9.70e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	41	3.53e-01	4.81e-01	0.12600	0.113000	5.59e-02	2.12e-01	5.36e-01
RNA Pol II CTD phosphorylation and interaction with CE	23	3.53e-01	4.81e-01	0.17000	0.042300	1.65e-01	7.26e-01	1.72e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	23	3.53e-01	4.81e-01	0.17000	0.042300	1.65e-01	7.26e-01	1.72e-01
RIP-mediated NFkB activation via ZBP1	14	3.55e-01	4.83e-01	0.21300	0.160000	1.41e-01	3.01e-01	3.62e-01
Positive epigenetic regulation of rRNA expression	37	3.55e-01	4.83e-01	0.14200	-0.122000	7.19e-02	1.99e-01	4.50e-01
TICAM1-dependent activation of IRF3/IRF7	12	3.56e-01	4.84e-01	0.23600	0.038600	2.33e-01	8.17e-01	1.63e-01
Mitochondrial iron-sulfur cluster biogenesis	10	3.57e-01	4.84e-01	0.25100	0.192000	1.62e-01	2.93e-01	3.75e-01
Activation of G protein gated Potassium channels	11	3.59e-01	4.85e-01	0.23900	0.146000	1.89e-01	4.01e-01	2.78e-01
G protein gated Potassium channels	11	3.59e-01	4.85e-01	0.23900	0.146000	1.89e-01	4.01e-01	2.78e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	11	3.59e-01	4.85e-01	0.23900	0.146000	1.89e-01	4.01e-01	2.78e-01
Transcriptional Regulation by MECP2	31	3.60e-01	4.87e-01	0.14600	0.144000	2.32e-02	1.65e-01	8.24e-01
Formation of RNA Pol II elongation complex	48	3.63e-01	4.90e-01	0.11600	0.036500	1.10e-01	6.63e-01	1.89e-01
RNA Polymerase II Transcription Elongation	48	3.63e-01	4.90e-01	0.11600	0.036500	1.10e-01	6.63e-01	1.89e-01
Nephrin family interactions	14	3.64e-01	4.90e-01	0.22700	-0.107000	2.00e-01	4.87e-01	1.96e-01
RAS processing	15	3.67e-01	4.93e-01	0.20500	0.064200	1.95e-01	6.67e-01	1.91e-01
Mismatch Repair	13	3.68e-01	4.93e-01	0.23400	-0.206000	1.11e-01	1.98e-01	4.89e-01
Signaling by PDGF	25	3.68e-01	4.93e-01	0.16300	0.163000	-1.55e-04	1.59e-01	9.99e-01
Non-integrin membrane-ECM interactions	14	3.68e-01	4.93e-01	0.21200	0.072900	1.99e-01	6.37e-01	1.98e-01
SLC transporter disorders	49	3.68e-01	4.93e-01	0.12100	-0.095900	7.45e-02	2.46e-01	3.67e-01
Retrograde transport at the Trans-Golgi-Network	45	3.69e-01	4.94e-01	0.12000	0.118000	1.83e-02	1.70e-01	8.32e-01
Synthesis of substrates in N-glycan biosythesis	48	3.72e-01	4.96e-01	0.11800	0.117000	-4.80e-03	1.60e-01	9.54e-01
Downregulation of TGF-beta receptor signaling	26	3.74e-01	4.98e-01	0.16500	0.139000	-8.96e-02	2.22e-01	4.29e-01
Protein localization	122	3.74e-01	4.98e-01	0.07350	0.073500	8.40e-04	1.62e-01	9.87e-01
NRIF signals cell death from the nucleus	14	3.78e-01	5.03e-01	0.22200	0.201000	-9.42e-02	1.93e-01	5.42e-01
FCERI mediated Ca+2 mobilization	25	3.80e-01	5.05e-01	0.16500	0.056600	-1.55e-01	6.25e-01	1.81e-01
E2F mediated regulation of DNA replication	18	3.81e-01	5.05e-01	0.19500	-0.087700	1.74e-01	5.20e-01	2.00e-01
Signaling by ERBB2	32	3.81e-01	5.05e-01	0.13700	0.116000	7.19e-02	2.56e-01	4.82e-01
RET signaling	22	3.81e-01	5.05e-01	0.17200	0.171000	-1.91e-02	1.65e-01	8.77e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	3.83e-01	5.07e-01	0.20300	-0.031100	-2.01e-01	8.35e-01	1.78e-01
RHOU GTPase cycle	26	3.84e-01	5.07e-01	0.15200	0.138000	6.32e-02	2.24e-01	5.77e-01
SUMOylation of transcription cofactors	35	3.84e-01	5.07e-01	0.13400	0.006490	1.34e-01	9.47e-01	1.70e-01
Cholesterol biosynthesis	20	3.89e-01	5.12e-01	0.18300	0.167000	-7.33e-02	1.95e-01	5.70e-01
Global Genome Nucleotide Excision Repair (GG-NER)	76	3.90e-01	5.13e-01	0.09270	-0.090300	2.08e-02	1.74e-01	7.55e-01
Interleukin-20 family signaling	13	3.91e-01	5.14e-01	0.21500	0.209000	5.00e-02	1.92e-01	7.55e-01
Signaling by EGFR in Cancer	16	3.91e-01	5.15e-01	0.19600	0.196000	1.27e-02	1.75e-01	9.30e-01
DNA Double Strand Break Response	35	3.92e-01	5.15e-01	0.13700	-0.048100	1.28e-01	6.23e-01	1.89e-01
Insulin processing	17	3.93e-01	5.15e-01	0.19500	0.188000	-5.31e-02	1.80e-01	7.05e-01
Pexophagy	10	3.93e-01	5.15e-01	0.24500	0.239000	5.24e-02	1.91e-01	7.74e-01
Amino acid transport across the plasma membrane	16	3.94e-01	5.16e-01	0.20500	0.149000	-1.41e-01	3.03e-01	3.28e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	21	3.97e-01	5.19e-01	0.16600	0.062000	1.54e-01	6.23e-01	2.22e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	37	3.98e-01	5.20e-01	0.12900	0.000187	-1.29e-01	9.98e-01	1.76e-01
Sensory processing of sound	25	4.03e-01	5.24e-01	0.16200	-0.083300	1.38e-01	4.71e-01	2.32e-01
Sensory processing of sound by inner hair cells of the cochlea	25	4.03e-01	5.24e-01	0.16200	-0.083300	1.38e-01	4.71e-01	2.32e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	12	4.03e-01	5.24e-01	0.22700	0.224000	-3.87e-02	1.79e-01	8.16e-01
Trafficking of AMPA receptors	12	4.03e-01	5.24e-01	0.22700	0.224000	-3.87e-02	1.79e-01	8.16e-01
DNA Damage/Telomere Stress Induced Senescence	23	4.03e-01	5.24e-01	0.16800	-0.081900	1.47e-01	4.97e-01	2.24e-01
Synthesis of very long-chain fatty acyl-CoAs	16	4.05e-01	5.25e-01	0.18900	0.057900	1.80e-01	6.88e-01	2.13e-01
DAG and IP3 signaling	26	4.06e-01	5.25e-01	0.15800	0.091500	-1.29e-01	4.20e-01	2.55e-01
p75NTR signals via NF-kB	11	4.06e-01	5.25e-01	0.22700	0.211000	8.21e-02	2.25e-01	6.37e-01
Removal of the Flap Intermediate from the C-strand	15	4.07e-01	5.25e-01	0.19800	-0.197000	-1.68e-02	1.86e-01	9.10e-01
Nuclear Envelope (NE) Reassembly	60	4.13e-01	5.33e-01	0.09520	0.062900	7.15e-02	4.01e-01	3.39e-01
CDC6 association with the ORC:origin complex	10	4.13e-01	5.33e-01	0.24700	-0.055900	2.40e-01	7.60e-01	1.89e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	22	4.13e-01	5.33e-01	0.17000	0.093600	-1.42e-01	4.47e-01	2.50e-01
Metabolism of porphyrins	15	4.14e-01	5.33e-01	0.19000	0.149000	1.18e-01	3.19e-01	4.28e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	14	4.15e-01	5.34e-01	0.21300	-0.155000	1.46e-01	3.16e-01	3.43e-01
PIWI-interacting RNA (piRNA) biogenesis	15	4.19e-01	5.38e-01	0.20300	-0.083700	1.85e-01	5.75e-01	2.16e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	4.23e-01	5.43e-01	0.22200	-0.216000	5.19e-02	1.95e-01	7.56e-01
Activation of kainate receptors upon glutamate binding	16	4.26e-01	5.45e-01	0.18100	0.149000	1.03e-01	3.01e-01	4.77e-01
Inwardly rectifying K+ channels	12	4.26e-01	5.45e-01	0.20900	0.116000	1.74e-01	4.85e-01	2.97e-01
Signaling by FGFR	51	4.28e-01	5.47e-01	0.10200	0.091100	4.57e-02	2.61e-01	5.73e-01
Collagen biosynthesis and modifying enzymes	17	4.32e-01	5.52e-01	0.18700	0.167000	-8.44e-02	2.33e-01	5.47e-01
Formation of TC-NER Pre-Incision Complex	45	4.34e-01	5.53e-01	0.10800	0.042400	9.93e-02	6.23e-01	2.50e-01
Synthesis of PIPs at the plasma membrane	36	4.34e-01	5.53e-01	0.12100	0.113000	4.25e-02	2.41e-01	6.60e-01
VEGFR2 mediated vascular permeability	22	4.39e-01	5.58e-01	0.15200	0.086800	1.25e-01	4.81e-01	3.12e-01
APC/C:Cdc20 mediated degradation of Cyclin B	22	4.39e-01	5.58e-01	0.15400	0.040800	1.49e-01	7.40e-01	2.27e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	34	4.40e-01	5.59e-01	0.13000	-0.037200	1.24e-01	7.08e-01	2.11e-01
Ovarian tumor domain proteases	28	4.41e-01	5.60e-01	0.14400	0.133000	-5.48e-02	2.25e-01	6.16e-01
Elastic fibre formation	17	4.44e-01	5.63e-01	0.18500	0.100000	-1.56e-01	4.75e-01	2.67e-01
Metalloprotease DUBs	16	4.51e-01	5.71e-01	0.18600	0.177000	-5.77e-02	2.20e-01	6.90e-01
Signaling by WNT in cancer	22	4.54e-01	5.74e-01	0.15100	0.144000	4.43e-02	2.42e-01	7.19e-01
Fatty acyl-CoA biosynthesis	26	4.60e-01	5.80e-01	0.13700	0.048900	1.28e-01	6.66e-01	2.58e-01
Regulation of IFNA signaling	12	4.60e-01	5.81e-01	0.19900	0.138000	1.43e-01	4.07e-01	3.91e-01
PI Metabolism	59	4.63e-01	5.83e-01	0.08960	0.066100	6.06e-02	3.81e-01	4.22e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	54	4.68e-01	5.89e-01	0.10100	-0.082700	5.77e-02	2.94e-01	4.64e-01
NOD1/2 Signaling Pathway	23	4.75e-01	5.97e-01	0.14200	0.123000	7.02e-02	3.07e-01	5.60e-01
Regulation of TP53 Activity through Methylation	17	4.77e-01	6.00e-01	0.16800	-0.167000	-2.11e-02	2.34e-01	8.81e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	10	4.78e-01	6.00e-01	0.21300	0.111000	1.82e-01	5.44e-01	3.19e-01
Netrin-1 signaling	25	4.79e-01	6.00e-01	0.13500	-0.109000	-7.88e-02	3.45e-01	4.96e-01
Interconversion of nucleotide di- and triphosphates	22	4.80e-01	6.01e-01	0.15500	0.098700	-1.20e-01	4.23e-01	3.31e-01
G alpha (s) signalling events	38	4.84e-01	6.06e-01	0.11700	0.099100	-6.23e-02	2.91e-01	5.07e-01
Diseases of DNA repair	10	4.85e-01	6.06e-01	0.22700	-0.204000	9.85e-02	2.64e-01	5.90e-01
Interferon gamma signaling	55	4.90e-01	6.11e-01	0.09710	-0.070700	6.66e-02	3.65e-01	3.94e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	11	4.94e-01	6.15e-01	0.19800	-0.130000	-1.50e-01	4.55e-01	3.90e-01
APC-Cdc20 mediated degradation of Nek2A	24	4.97e-01	6.19e-01	0.14100	-0.017900	1.39e-01	8.79e-01	2.38e-01
Meiotic synapsis	23	4.98e-01	6.20e-01	0.14800	-0.118000	8.90e-02	3.27e-01	4.60e-01
Metabolism of cofactors	17	5.01e-01	6.23e-01	0.16200	0.160000	2.70e-02	2.54e-01	8.47e-01
RUNX3 regulates NOTCH signaling	11	5.02e-01	6.23e-01	0.20600	0.204000	-2.12e-02	2.40e-01	9.03e-01
Signalling to RAS	13	5.03e-01	6.24e-01	0.18500	0.183000	2.67e-02	2.53e-01	8.68e-01
Phase I - Functionalization of compounds	30	5.15e-01	6.39e-01	0.11900	-0.026800	-1.16e-01	7.99e-01	2.72e-01
Regulation of FZD by ubiquitination	11	5.19e-01	6.42e-01	0.20700	0.177000	-1.08e-01	3.11e-01	5.37e-01
RHOV GTPase cycle	24	5.25e-01	6.49e-01	0.13900	0.093100	-1.04e-01	4.30e-01	3.79e-01
DNA Damage Bypass	41	5.26e-01	6.50e-01	0.10100	-0.099700	-1.51e-02	2.70e-01	8.67e-01
Processing of SMDT1	12	5.31e-01	6.55e-01	0.18000	0.139000	1.15e-01	4.06e-01	4.92e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	19	5.35e-01	6.59e-01	0.15300	-0.066300	1.38e-01	6.17e-01	2.99e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	19	5.35e-01	6.59e-01	0.15300	-0.066300	1.38e-01	6.17e-01	2.99e-01
Metabolism of nitric oxide: NOS3 activation and regulation	11	5.37e-01	6.60e-01	0.20000	0.180000	-8.68e-02	3.01e-01	6.18e-01
Elevation of cytosolic Ca2+ levels	10	5.37e-01	6.60e-01	0.21100	0.115000	-1.77e-01	5.28e-01	3.33e-01
B-WICH complex positively regulates rRNA expression	24	5.42e-01	6.65e-01	0.13100	-0.130000	8.06e-03	2.69e-01	9.46e-01
Molecules associated with elastic fibres	12	5.43e-01	6.65e-01	0.17900	-0.053600	-1.71e-01	7.48e-01	3.04e-01
DCC mediated attractive signaling	11	5.43e-01	6.65e-01	0.18500	-0.162000	-8.96e-02	3.52e-01	6.07e-01
Transcriptional regulation by RUNX1	133	5.47e-01	6.69e-01	0.05420	0.052900	1.21e-02	2.95e-01	8.10e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	22	5.50e-01	6.72e-01	0.13500	-0.009690	1.35e-01	9.37e-01	2.74e-01
Caspase-mediated cleavage of cytoskeletal proteins	10	5.51e-01	6.72e-01	0.19400	0.060100	1.85e-01	7.42e-01	3.12e-01
Formation of the beta-catenin:TCF transactivating complex	24	5.51e-01	6.72e-01	0.12900	-0.007490	1.29e-01	9.49e-01	2.75e-01
Keratan sulfate/keratin metabolism	19	5.51e-01	6.72e-01	0.14300	0.142000	1.44e-02	2.83e-01	9.13e-01
Chaperone Mediated Autophagy	12	5.52e-01	6.72e-01	0.17400	0.128000	1.18e-01	4.43e-01	4.80e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	68	5.57e-01	6.75e-01	0.07910	-0.057700	5.41e-02	4.12e-01	4.41e-01
Disorders of Developmental Biology	10	5.58e-01	6.75e-01	0.20500	0.172000	-1.11e-01	3.47e-01	5.44e-01
Disorders of Nervous System Development	10	5.58e-01	6.75e-01	0.20500	0.172000	-1.11e-01	3.47e-01	5.44e-01
Loss of function of MECP2 in Rett syndrome	10	5.58e-01	6.75e-01	0.20500	0.172000	-1.11e-01	3.47e-01	5.44e-01
Pervasive developmental disorders	10	5.58e-01	6.75e-01	0.20500	0.172000	-1.11e-01	3.47e-01	5.44e-01
Adrenaline,noradrenaline inhibits insulin secretion	14	5.60e-01	6.77e-01	0.16100	0.061600	1.49e-01	6.90e-01	3.35e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	5.62e-01	6.79e-01	0.15000	-0.050500	1.41e-01	7.11e-01	3.01e-01
Nuclear Receptor transcription pathway	26	5.63e-01	6.79e-01	0.12500	-0.113000	5.49e-02	3.20e-01	6.28e-01
Anchoring of the basal body to the plasma membrane	79	5.65e-01	6.82e-01	0.07060	-0.069200	1.41e-02	2.89e-01	8.29e-01
NOTCH4 Intracellular Domain Regulates Transcription	14	5.70e-01	6.86e-01	0.17000	0.097900	-1.39e-01	5.26e-01	3.68e-01
Nucleotide Excision Repair	98	5.70e-01	6.86e-01	0.06320	-0.061100	1.63e-02	2.97e-01	7.81e-01
VEGFR2 mediated cell proliferation	16	5.73e-01	6.88e-01	0.15700	0.061300	-1.44e-01	6.71e-01	3.18e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	14	5.73e-01	6.88e-01	0.15600	0.124000	9.43e-02	4.20e-01	5.41e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	14	5.73e-01	6.88e-01	0.15600	0.124000	9.43e-02	4.20e-01	5.41e-01
mRNA Capping	25	5.77e-01	6.91e-01	0.12100	-0.001200	1.21e-01	9.92e-01	2.96e-01
Regulation of TNFR1 signaling	30	5.79e-01	6.93e-01	0.10600	-0.090700	-5.53e-02	3.91e-01	6.01e-01
Purine catabolism	10	5.80e-01	6.93e-01	0.19600	0.183000	-7.07e-02	3.18e-01	6.99e-01
Formation of Incision Complex in GG-NER	36	5.81e-01	6.93e-01	0.10400	-0.043400	9.40e-02	6.52e-01	3.30e-01
Platelet calcium homeostasis	17	5.84e-01	6.96e-01	0.15100	0.128000	-8.03e-02	3.63e-01	5.67e-01
Base-Excision Repair, AP Site Formation	13	5.86e-01	6.98e-01	0.16000	-0.148000	-6.26e-02	3.57e-01	6.96e-01
Dual incision in TC-NER	55	5.87e-01	6.99e-01	0.08350	-0.070800	4.43e-02	3.65e-01	5.71e-01
Tie2 Signaling	10	5.89e-01	7.00e-01	0.18800	0.188000	-5.31e-03	3.04e-01	9.77e-01
RORA activates gene expression	10	5.91e-01	7.02e-01	0.19400	0.165000	-1.02e-01	3.65e-01	5.78e-01
Integrin cell surface interactions	25	5.91e-01	7.02e-01	0.11800	0.117000	6.63e-03	3.10e-01	9.54e-01
Regulation of RUNX1 Expression and Activity	15	5.94e-01	7.04e-01	0.14600	-0.097100	-1.09e-01	5.15e-01	4.66e-01
Transcriptional Regulation by VENTX	30	5.94e-01	7.04e-01	0.10900	-0.107000	2.12e-02	3.11e-01	8.41e-01
Nicotinamide salvaging	11	5.98e-01	7.07e-01	0.18400	-0.122000	1.38e-01	4.85e-01	4.29e-01
NOTCH3 Intracellular Domain Regulates Transcription	15	5.98e-01	7.07e-01	0.14800	0.145000	3.11e-02	3.31e-01	8.35e-01
Cardiac conduction	40	6.01e-01	7.10e-01	0.08840	-0.055500	-6.88e-02	5.44e-01	4.52e-01
Metabolism of water-soluble vitamins and cofactors	79	6.06e-01	7.15e-01	0.06400	-0.062500	-1.36e-02	3.38e-01	8.35e-01
NCAM signaling for neurite out-growth	22	6.07e-01	7.15e-01	0.12200	-0.122000	-4.02e-03	3.21e-01	9.74e-01
RNA Polymerase III Transcription Termination	20	6.08e-01	7.15e-01	0.13400	-0.067200	1.15e-01	6.03e-01	3.72e-01
Glutathione conjugation	20	6.08e-01	7.15e-01	0.13400	0.109000	-7.72e-02	3.98e-01	5.50e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	26	6.17e-01	7.25e-01	0.10700	-0.068100	-8.23e-02	5.48e-01	4.68e-01
Ca2+ pathway	39	6.25e-01	7.32e-01	0.08650	0.075800	4.16e-02	4.13e-01	6.53e-01
Vitamin B5 (pantothenate) metabolism	11	6.27e-01	7.32e-01	0.17000	0.167000	-3.15e-02	3.36e-01	8.57e-01
Synthesis of PIPs at the early endosome membrane	12	6.27e-01	7.32e-01	0.16300	-0.024800	1.61e-01	8.82e-01	3.35e-01
RND2 GTPase cycle	32	6.28e-01	7.32e-01	0.10200	0.083100	-6.00e-02	4.17e-01	5.58e-01
Assembly of collagen fibrils and other multimeric structures	14	6.28e-01	7.32e-01	0.15100	0.148000	-3.17e-02	3.39e-01	8.38e-01
Deadenylation of mRNA	21	6.28e-01	7.32e-01	0.12300	0.121000	-2.11e-02	3.37e-01	8.67e-01
Mitochondrial translation initiation	83	6.30e-01	7.32e-01	0.05880	-0.047500	-3.45e-02	4.55e-01	5.87e-01
CD209 (DC-SIGN) signaling	15	6.30e-01	7.32e-01	0.13800	0.124000	6.15e-02	4.06e-01	6.80e-01
Interleukin-7 signaling	14	6.32e-01	7.32e-01	0.14300	0.125000	6.81e-02	4.17e-01	6.59e-01
Interleukin-37 signaling	17	6.32e-01	7.32e-01	0.13700	0.042300	-1.30e-01	7.63e-01	3.52e-01
Deactivation of the beta-catenin transactivating complex	28	6.32e-01	7.32e-01	0.10000	0.074000	6.76e-02	4.98e-01	5.36e-01
Activation of HOX genes during differentiation	38	6.32e-01	7.32e-01	0.09280	0.042500	-8.24e-02	6.50e-01	3.80e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	38	6.32e-01	7.32e-01	0.09280	0.042500	-8.24e-02	6.50e-01	3.80e-01
Caspase activation via Death Receptors in the presence of ligand	10	6.33e-01	7.32e-01	0.17400	0.174000	-4.30e-05	3.40e-01	1.00e+00
TNFR1-induced NFkappaB signaling pathway	19	6.33e-01	7.32e-01	0.12900	-0.126000	2.88e-02	3.44e-01	8.28e-01
SUMOylation of DNA methylation proteins	14	6.37e-01	7.37e-01	0.14900	-0.030600	1.45e-01	8.43e-01	3.46e-01
Phase II - Conjugation of compounds	44	6.38e-01	7.37e-01	0.08570	0.046100	-7.22e-02	5.97e-01	4.08e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	34	6.41e-01	7.39e-01	0.09080	-0.085000	-3.21e-02	3.92e-01	7.46e-01
Bile acid and bile salt metabolism	14	6.41e-01	7.39e-01	0.14800	0.031700	-1.44e-01	8.37e-01	3.50e-01
G1/S-Specific Transcription	25	6.46e-01	7.44e-01	0.11200	-0.093300	6.21e-02	4.20e-01	5.91e-01
Signaling by ERBB2 KD Mutants	11	6.51e-01	7.49e-01	0.15900	-0.026700	-1.56e-01	8.78e-01	3.69e-01
Mitochondrial Fatty Acid Beta-Oxidation	25	6.56e-01	7.54e-01	0.10500	-0.011900	-1.04e-01	9.18e-01	3.68e-01
Glycolysis	57	6.57e-01	7.54e-01	0.06750	0.040300	5.41e-02	5.99e-01	4.81e-01
TRAF6 mediated IRF7 activation	15	6.58e-01	7.55e-01	0.13900	0.033700	-1.35e-01	8.21e-01	3.67e-01
Post-translational modification: synthesis of GPI-anchored proteins	28	6.69e-01	7.67e-01	0.09940	0.021400	-9.71e-02	8.45e-01	3.74e-01
Downstream signal transduction	21	6.70e-01	7.67e-01	0.11600	0.108000	-4.17e-02	3.92e-01	7.41e-01
Mitochondrial protein import	47	6.78e-01	7.75e-01	0.07130	-0.049900	-5.10e-02	5.55e-01	5.46e-01
Chondroitin sulfate/dermatan sulfate metabolism	26	6.80e-01	7.76e-01	0.10400	0.071300	-7.53e-02	5.29e-01	5.07e-01
Regulation of MECP2 expression and activity	23	6.80e-01	7.76e-01	0.10300	0.096500	3.52e-02	4.23e-01	7.70e-01
Mitochondrial translation elongation	83	6.81e-01	7.76e-01	0.05420	-0.051000	-1.84e-02	4.23e-01	7.73e-01
Negative regulators of DDX58/IFIH1 signaling	33	6.82e-01	7.77e-01	0.09010	-0.029500	8.51e-02	7.70e-01	3.98e-01
Mitochondrial translation termination	82	6.84e-01	7.79e-01	0.05360	-0.044800	-2.94e-02	4.85e-01	6.46e-01
Mitochondrial calcium ion transport	18	6.87e-01	7.81e-01	0.11500	0.109000	3.49e-02	4.22e-01	7.98e-01
Signaling by KIT in disease	17	6.91e-01	7.85e-01	0.12500	-0.108000	6.25e-02	4.42e-01	6.56e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	17	6.91e-01	7.85e-01	0.12500	-0.108000	6.25e-02	4.42e-01	6.56e-01
Heparan sulfate/heparin (HS-GAG) metabolism	19	6.96e-01	7.89e-01	0.11700	0.062400	-9.88e-02	6.38e-01	4.56e-01
Long-term potentiation	10	6.98e-01	7.89e-01	0.14800	-0.096300	-1.13e-01	5.98e-01	5.37e-01
NR1H2 and NR1H3-mediated signaling	26	6.99e-01	7.89e-01	0.09220	0.075600	5.28e-02	5.05e-01	6.42e-01
DAP12 interactions	23	6.99e-01	7.89e-01	0.09840	0.086700	4.65e-02	4.72e-01	7.00e-01
Purine salvage	11	6.99e-01	7.89e-01	0.15100	0.140000	-5.86e-02	4.23e-01	7.37e-01
Sensory Perception	62	7.05e-01	7.95e-01	0.06370	-0.030900	5.56e-02	6.74e-01	4.49e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	19	7.06e-01	7.95e-01	0.11500	0.071200	-9.04e-02	5.91e-01	4.95e-01
Diseases associated with glycosaminoglycan metabolism	15	7.08e-01	7.96e-01	0.12800	0.112000	-6.33e-02	4.54e-01	6.71e-01
PI3K Cascade	18	7.08e-01	7.96e-01	0.11200	0.010600	1.11e-01	9.38e-01	4.13e-01
Metabolism of folate and pterines	11	7.12e-01	8.00e-01	0.13800	0.096400	9.81e-02	5.80e-01	5.73e-01
SUMOylation of intracellular receptors	19	7.18e-01	8.06e-01	0.10800	0.108000	6.57e-04	4.17e-01	9.96e-01
Nicotinate metabolism	19	7.20e-01	8.07e-01	0.11100	-0.102000	4.22e-02	4.41e-01	7.50e-01
Inactivation, recovery and regulation of the phototransduction cascade	16	7.22e-01	8.07e-01	0.12100	-0.105000	5.97e-02	4.68e-01	6.79e-01
The phototransduction cascade	16	7.22e-01	8.07e-01	0.12100	-0.105000	5.97e-02	4.68e-01	6.79e-01
Diseases of glycosylation	68	7.22e-01	8.07e-01	0.05550	0.013300	5.39e-02	8.50e-01	4.43e-01
Telomere Extension By Telomerase	20	7.23e-01	8.08e-01	0.10800	-0.094400	5.17e-02	4.65e-01	6.89e-01
Translesion Synthesis by POLH	16	7.29e-01	8.13e-01	0.11900	-0.096700	7.00e-02	5.03e-01	6.28e-01
Kinesins	31	7.29e-01	8.13e-01	0.08150	-0.008820	-8.11e-02	9.32e-01	4.35e-01
Glucose metabolism	72	7.30e-01	8.13e-01	0.05320	0.052300	9.80e-03	4.44e-01	8.86e-01
Synthesis of glycosylphosphatidylinositol (GPI)	13	7.32e-01	8.15e-01	0.12300	-0.116000	-3.99e-02	4.68e-01	8.04e-01
DNA Damage Recognition in GG-NER	35	7.33e-01	8.15e-01	0.07490	-0.070800	-2.45e-02	4.69e-01	8.02e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	7.33e-01	8.15e-01	0.11300	-0.082000	-7.71e-02	5.82e-01	6.05e-01
FOXO-mediated transcription of cell cycle genes	13	7.38e-01	8.20e-01	0.12000	-0.056800	-1.06e-01	7.23e-01	5.08e-01
Nonhomologous End-Joining (NHEJ)	28	7.39e-01	8.20e-01	0.08670	-0.083000	2.49e-02	4.47e-01	8.20e-01
Signaling by ERBB2 in Cancer	12	7.40e-01	8.20e-01	0.13300	0.045500	-1.25e-01	7.85e-01	4.55e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	22	7.42e-01	8.20e-01	0.09140	0.053400	7.42e-02	6.65e-01	5.47e-01
HDMs demethylate histones	13	7.42e-01	8.20e-01	0.12000	0.047200	1.10e-01	7.69e-01	4.92e-01
Early Phase of HIV Life Cycle	13	7.42e-01	8.20e-01	0.12400	-0.124000	1.16e-02	4.40e-01	9.42e-01
Synthesis of PA	18	7.43e-01	8.20e-01	0.10500	-0.105000	1.32e-03	4.42e-01	9.92e-01
Signaling by NTRK2 (TRKB)	16	7.44e-01	8.20e-01	0.10700	0.090200	5.71e-02	5.33e-01	6.93e-01
Heme biosynthesis	10	7.44e-01	8.20e-01	0.13500	0.076200	1.11e-01	6.77e-01	5.43e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	27	7.47e-01	8.21e-01	0.08240	-0.076200	-3.13e-02	4.93e-01	7.79e-01
Interleukin-2 family signaling	29	7.47e-01	8.21e-01	0.08470	0.074900	-3.94e-02	4.85e-01	7.14e-01
Regulation of KIT signaling	11	7.52e-01	8.26e-01	0.13500	-0.055900	1.23e-01	7.48e-01	4.79e-01
RNA Polymerase II Transcription Termination	42	7.53e-01	8.26e-01	0.06450	0.040300	5.04e-02	6.52e-01	5.73e-01
ATF4 activates genes in response to endoplasmic reticulum stress	23	7.63e-01	8.36e-01	0.08570	0.037900	7.68e-02	7.53e-01	5.24e-01
Heme signaling	24	7.65e-01	8.38e-01	0.08270	0.051200	6.50e-02	6.65e-01	5.82e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	12	7.70e-01	8.43e-01	0.11600	0.051600	1.04e-01	7.57e-01	5.32e-01
Circadian Clock	50	7.75e-01	8.46e-01	0.06070	0.049700	-3.49e-02	5.44e-01	6.70e-01
Ion homeostasis	26	7.75e-01	8.46e-01	0.07850	-0.029700	-7.26e-02	7.94e-01	5.22e-01
Mitochondrial translation	88	7.82e-01	8.53e-01	0.04160	-0.032600	-2.58e-02	5.98e-01	6.76e-01
Recruitment of NuMA to mitotic centrosomes	63	7.94e-01	8.65e-01	0.04890	-0.048400	-6.89e-03	5.07e-01	9.25e-01
Synthesis of bile acids and bile salts	13	7.97e-01	8.66e-01	0.11100	0.044800	-1.02e-01	7.80e-01	5.25e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	23	7.97e-01	8.66e-01	0.07800	0.065300	4.26e-02	5.88e-01	7.24e-01
Cytochrome P450 - arranged by substrate type	14	7.98e-01	8.66e-01	0.09980	0.084300	5.33e-02	5.85e-01	7.30e-01
Glyoxylate metabolism and glycine degradation	19	7.98e-01	8.66e-01	0.08890	-0.001510	8.89e-02	9.91e-01	5.03e-01
DAP12 signaling	21	7.98e-01	8.66e-01	0.08470	0.084600	-2.84e-03	5.02e-01	9.82e-01
Constitutive Signaling by EGFRvIII	10	8.00e-01	8.66e-01	0.11700	0.099200	6.25e-02	5.87e-01	7.32e-01
Signaling by EGFRvIII in Cancer	10	8.00e-01	8.66e-01	0.11700	0.099200	6.25e-02	5.87e-01	7.32e-01
KSRP (KHSRP) binds and destabilizes mRNA	15	8.00e-01	8.66e-01	0.10200	-0.028600	9.74e-02	8.48e-01	5.14e-01
Interleukin-35 Signalling	11	8.01e-01	8.66e-01	0.11500	-0.114000	-1.26e-02	5.13e-01	9.42e-01
Branched-chain amino acid catabolism	19	8.03e-01	8.67e-01	0.08840	-0.087800	9.96e-03	5.08e-01	9.40e-01
mRNA 3’-end processing	35	8.04e-01	8.67e-01	0.06230	0.029600	5.49e-02	7.62e-01	5.75e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	8.04e-01	8.67e-01	0.09040	-0.009340	8.99e-02	9.45e-01	5.09e-01
Cleavage of the damaged pyrimidine	12	8.09e-01	8.69e-01	0.10500	-0.090700	-5.22e-02	5.87e-01	7.54e-01
Depyrimidination	12	8.09e-01	8.69e-01	0.10500	-0.090700	-5.22e-02	5.87e-01	7.54e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	12	8.09e-01	8.69e-01	0.10500	-0.090700	-5.22e-02	5.87e-01	7.54e-01
N-Glycan antennae elongation	11	8.16e-01	8.76e-01	0.10800	-0.030800	-1.04e-01	8.60e-01	5.52e-01
Cell surface interactions at the vascular wall	57	8.17e-01	8.76e-01	0.04960	0.048000	-1.26e-02	5.32e-01	8.70e-01
Centrosome maturation	64	8.18e-01	8.76e-01	0.04670	-0.045300	1.14e-02	5.32e-01	8.75e-01
Recruitment of mitotic centrosome proteins and complexes	64	8.18e-01	8.76e-01	0.04670	-0.045300	1.14e-02	5.32e-01	8.75e-01
Signaling by ERBB2 ECD mutants	10	8.23e-01	8.80e-01	0.10900	-0.075100	-7.95e-02	6.81e-01	6.64e-01
Signaling by Retinoic Acid	17	8.26e-01	8.83e-01	0.08810	0.021700	-8.54e-02	8.77e-01	5.42e-01
Endosomal/Vacuolar pathway	11	8.26e-01	8.83e-01	0.10600	-0.106000	-1.13e-02	5.44e-01	9.48e-01
SUMOylation of transcription factors	12	8.30e-01	8.86e-01	0.10600	0.085900	-6.15e-02	6.06e-01	7.12e-01
Phosphorylation of the APC/C	18	8.36e-01	8.91e-01	0.08090	0.003050	8.09e-02	9.82e-01	5.53e-01
G0 and Early G1	24	8.36e-01	8.91e-01	0.07340	-0.055400	4.81e-02	6.39e-01	6.83e-01
Cargo trafficking to the periciliary membrane	40	8.41e-01	8.95e-01	0.05180	0.025000	4.54e-02	7.85e-01	6.20e-01
Diseases of mitotic cell cycle	34	8.44e-01	8.96e-01	0.06020	-0.047300	3.72e-02	6.34e-01	7.08e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	33	8.44e-01	8.96e-01	0.05670	0.024800	5.10e-02	8.05e-01	6.13e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	13	8.47e-01	8.98e-01	0.08860	0.060400	6.47e-02	7.06e-01	6.86e-01
Transcriptional activation of mitochondrial biogenesis	36	8.52e-01	9.03e-01	0.05530	-0.054400	9.88e-03	5.73e-01	9.18e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	13	8.55e-01	9.06e-01	0.08680	-0.080700	-3.21e-02	6.15e-01	8.41e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	8.57e-01	9.06e-01	0.08140	0.015700	-7.99e-02	9.14e-01	5.80e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	8.57e-01	9.06e-01	0.08140	0.015700	-7.99e-02	9.14e-01	5.80e-01
Role of phospholipids in phagocytosis	16	8.61e-01	9.09e-01	0.08240	0.056600	-5.98e-02	6.95e-01	6.79e-01
Regulation of innate immune responses to cytosolic DNA	12	8.61e-01	9.09e-01	0.09110	-0.003140	9.10e-02	9.85e-01	5.85e-01
Diseases of metabolism	120	8.62e-01	9.09e-01	0.03010	0.023200	-1.91e-02	6.62e-01	7.18e-01
Mitochondrial biogenesis	50	8.65e-01	9.11e-01	0.04250	-0.020200	-3.74e-02	8.05e-01	6.48e-01
Processing of Intronless Pre-mRNAs	14	8.65e-01	9.11e-01	0.07980	-0.066400	-4.41e-02	6.67e-01	7.75e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	8.69e-01	9.14e-01	0.07940	0.045600	-6.50e-02	7.52e-01	6.53e-01
PERK regulates gene expression	26	8.70e-01	9.14e-01	0.05730	0.037700	4.31e-02	7.40e-01	7.04e-01
Class B/2 (Secretin family receptors)	26	8.72e-01	9.15e-01	0.06170	0.038000	-4.86e-02	7.38e-01	6.68e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	18	8.82e-01	9.25e-01	0.07070	-0.035200	6.13e-02	7.96e-01	6.52e-01
RUNX3 regulates p14-ARF	10	8.82e-01	9.25e-01	0.09370	0.087600	-3.30e-02	6.31e-01	8.57e-01
TNF signaling	37	8.86e-01	9.27e-01	0.04850	-0.024900	4.16e-02	7.93e-01	6.62e-01
STING mediated induction of host immune responses	10	8.89e-01	9.30e-01	0.08760	0.087200	8.19e-03	6.33e-01	9.64e-01
Synthesis of PIPs at the Golgi membrane	12	8.91e-01	9.31e-01	0.08050	-0.006940	8.02e-02	9.67e-01	6.31e-01
Signaling by FGFR2 IIIa TM	14	8.95e-01	9.34e-01	0.07400	0.072000	-1.69e-02	6.41e-01	9.13e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	12	9.00e-01	9.39e-01	0.07680	-0.076400	7.13e-03	6.47e-01	9.66e-01
Cell-cell junction organization	12	9.07e-01	9.45e-01	0.07620	0.036900	-6.66e-02	8.25e-01	6.90e-01
Regulation of BACH1 activity	11	9.11e-01	9.48e-01	0.07400	0.072600	1.42e-02	6.77e-01	9.35e-01
Interleukin receptor SHC signaling	16	9.12e-01	9.48e-01	0.06150	0.061300	4.79e-03	6.71e-01	9.74e-01
Signaling by NTRK3 (TRKC)	12	9.13e-01	9.49e-01	0.07300	0.026000	-6.82e-02	8.76e-01	6.83e-01
Cyclin D associated events in G1	41	9.16e-01	9.50e-01	0.03920	0.020200	-3.36e-02	8.23e-01	7.10e-01
G1 Phase	41	9.16e-01	9.50e-01	0.03920	0.020200	-3.36e-02	8.23e-01	7.10e-01
RND1 GTPase cycle	29	9.16e-01	9.50e-01	0.04520	0.045000	-4.66e-03	6.75e-01	9.65e-01
Termination of O-glycan biosynthesis	10	9.18e-01	9.50e-01	0.07320	0.066700	3.01e-02	7.15e-01	8.69e-01
O-linked glycosylation	42	9.27e-01	9.59e-01	0.03420	-0.033700	-6.02e-03	7.06e-01	9.46e-01
Transcription of E2F targets under negative control by DREAM complex	18	9.28e-01	9.59e-01	0.05480	-0.044600	3.19e-02	7.44e-01	8.15e-01
IRS-mediated signalling	21	9.32e-01	9.62e-01	0.04710	0.001350	4.71e-02	9.91e-01	7.09e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	10	9.33e-01	9.62e-01	0.06680	0.065200	1.45e-02	7.21e-01	9.37e-01
CLEC7A (Dectin-1) induces NFAT activation	11	9.33e-01	9.62e-01	0.06720	-0.055100	3.85e-02	7.52e-01	8.25e-01
IGF1R signaling cascade	23	9.36e-01	9.64e-01	0.04290	0.041900	8.90e-03	7.28e-01	9.41e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	23	9.36e-01	9.64e-01	0.04290	0.041900	8.90e-03	7.28e-01	9.41e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	33	9.39e-01	9.66e-01	0.03710	-0.025100	2.74e-02	8.03e-01	7.86e-01
Potassium Channels	25	9.41e-01	9.66e-01	0.03920	0.015500	3.60e-02	8.94e-01	7.56e-01
Polo-like kinase mediated events	15	9.41e-01	9.66e-01	0.05090	0.050100	8.84e-03	7.37e-01	9.53e-01
Downstream signaling of activated FGFR1	12	9.44e-01	9.66e-01	0.05450	0.047500	2.67e-02	7.76e-01	8.73e-01
Downstream signaling of activated FGFR2	12	9.44e-01	9.66e-01	0.05450	0.047500	2.67e-02	7.76e-01	8.73e-01
Downstream signaling of activated FGFR3	12	9.44e-01	9.66e-01	0.05450	0.047500	2.67e-02	7.76e-01	8.73e-01
Downstream signaling of activated FGFR4	12	9.44e-01	9.66e-01	0.05450	0.047500	2.67e-02	7.76e-01	8.73e-01
Signaling by PDGFR in disease	16	9.47e-01	9.66e-01	0.04590	0.030800	3.40e-02	8.31e-01	8.14e-01
FGFR2 mutant receptor activation	15	9.47e-01	9.66e-01	0.04740	0.028100	3.82e-02	8.51e-01	7.98e-01
Signaling by BMP	14	9.47e-01	9.66e-01	0.04960	-0.017800	-4.63e-02	9.08e-01	7.64e-01
Basigin interactions	14	9.51e-01	9.69e-01	0.05100	-0.039300	3.25e-02	7.99e-01	8.33e-01
Association of TriC/CCT with target proteins during biosynthesis	29	9.57e-01	9.74e-01	0.03080	0.013500	2.77e-02	9.00e-01	7.96e-01
TRAF3-dependent IRF activation pathway	13	9.61e-01	9.76e-01	0.04670	0.025400	-3.92e-02	8.74e-01	8.07e-01
Miscellaneous transport and binding events	14	9.62e-01	9.76e-01	0.04440	-0.020600	3.93e-02	8.94e-01	7.99e-01
Loss of Nlp from mitotic centrosomes	55	9.62e-01	9.76e-01	0.02090	-0.018600	-9.67e-03	8.12e-01	9.01e-01
Loss of proteins required for interphase microtubule organization from the centrosome	55	9.62e-01	9.76e-01	0.02090	-0.018600	-9.67e-03	8.12e-01	9.01e-01
IRS-related events triggered by IGF1R	22	9.64e-01	9.77e-01	0.03220	0.027100	1.74e-02	8.26e-01	8.88e-01
Condensation of Prometaphase Chromosomes	10	9.66e-01	9.79e-01	0.04880	-0.011800	4.73e-02	9.48e-01	7.96e-01
Deadenylation-dependent mRNA decay	50	9.70e-01	9.81e-01	0.01970	-0.019300	-4.24e-03	8.14e-01	9.59e-01
Inhibition of DNA recombination at telomere	16	9.70e-01	9.81e-01	0.03420	0.015300	3.06e-02	9.16e-01	8.32e-01
AURKA Activation by TPX2	58	9.72e-01	9.81e-01	0.01790	-0.004060	-1.74e-02	9.57e-01	8.19e-01
FGFR2 alternative splicing	21	9.72e-01	9.81e-01	0.03130	0.018400	-2.52e-02	8.84e-01	8.41e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	57	9.74e-01	9.83e-01	0.01680	0.012400	1.14e-02	8.72e-01	8.82e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	15	9.77e-01	9.84e-01	0.03190	-0.006450	-3.12e-02	9.65e-01	8.34e-01
Keratan sulfate biosynthesis	15	9.77e-01	9.84e-01	0.03340	-0.016600	2.90e-02	9.11e-01	8.46e-01
Processing of Capped Intronless Pre-mRNA	21	9.81e-01	9.86e-01	0.02410	-0.013100	-2.02e-02	9.18e-01	8.73e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	14	9.91e-01	9.95e-01	0.02120	0.021100	-1.18e-03	8.91e-01	9.94e-01
Metabolism of vitamins and cofactors	107	9.92e-01	9.95e-01	0.00727	0.006880	-2.36e-03	9.02e-01	9.67e-01
Methylation	10	9.92e-01	9.95e-01	0.02290	-0.022900	7.74e-04	9.00e-01	9.97e-01
Signaling by FGFR2 in disease	23	9.92e-01	9.95e-01	0.01490	-0.000580	1.49e-02	9.96e-01	9.02e-01
TP53 Regulates Transcription of Cell Cycle Genes	43	9.93e-01	9.95e-01	0.01070	0.008350	-6.67e-03	9.25e-01	9.40e-01
Visual phototransduction	31	9.96e-01	9.96e-01	0.00938	-0.004630	-8.16e-03	9.64e-01	9.37e-01
Regulation of PLK1 Activity at G2/M Transition	73	9.99e-01	9.99e-01	0.00298	0.002930	-5.81e-04	9.66e-01	9.93e-01

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Detailed Gene set reports

Neutrophil degranulation

Neutrophil degranulation

metric	value
setSize	305
pMANOVA	5.8e-54
p.adjustMANOVA	6.73e-51
s.dist	0.525
s.RNA	0.523
s.meth	-0.0499
p.RNA	2.98e-55
p.meth	0.138

Top 20 genes

Gene	RNA	meth
CKAP4	4355	-6717
MNDA	4303	-6779
CYFIP1	4295	-6630
CTSZ	4137	-6765
RAB3D	4263	-6515
TRPM2	4205	-6600
QPCT	4331	-6405
TLR2	4206	-6586
PLD1	4321	-6058
PYCARD	3942	-6598
LAMTOR1	4371	-5950
BRI3	4159	-6229
P2RX1	3829	-6722
ATP6V0A1	4375	-5877
ALOX5	4150	-6082
CREG1	4403	-5637
GCA	4384	-5597
C3AR1	3573	-6729
CAPN1	3902	-6119
PLAUR	3822	-6237

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2170	-3533
ACAA1	3734	1410
ACLY	1961	-5417
ACTR10	3309	-1291
ACTR1B	-3828	-3653
ACTR2	3481	-3374
ADAM10	4030	976
ADAM8	2208	-5902
ADGRE5	-769	-5511
AGA	-1396	-2458
AGL	-940	-3188
AGPAT2	4289	2250
ALAD	3874	-1369
ALDOA	4285	-1349
ALDOC	-1028	-6226
ALOX5	4150	-6082
AMPD3	3997	-5620
ANO6	3597	-3634
AP1M1	2798	-2408
APAF1	4158	-2104
APEH	314	1724
APRT	-834	-204
ARHGAP9	2545	2156
ARL8A	3713	-6230
ARMC8	2620	-1033
ARPC5	3968	-3837
ARSA	1183	-3099
ARSB	3290	-5722
ASAH1	3880	335
ATAD3B	-3588	-1948
ATG7	3647	569
ATP11A	3801	-5671
ATP11B	2429	1806
ATP6V0A1	4375	-5877
ATP6V0C	4218	-4697
ATP6V1D	4174	-1234
ATP8A1	-4599	-250
ATP8B4	2945	1090
B2M	-2195	-2389
B4GALT1	1540	-160
BIN2	2264	-2805
BRI3	4159	-6229
BST2	-2378	-1970
C3AR1	3573	-6729
C6orf120	2508	1218
CAB39	3728	-2802
CAND1	-2041	-421
CAP1	3635	-553
CAPN1	3902	-6119
CAT	4214	-3922
CCT2	-3002	-727
CCT8	2708	-1245
CD300A	-641	-6466
CD44	3760	266
CD47	-4754	-114
CD53	3492	2243
CD55	4229	-3923
CD58	2766	-3228
CD59	2326	-6024
CD63	4308	-1017
CDK13	-2814	-700
CEACAM1	3825	-5827
CEP290	-3161	-2056
CKAP4	4355	-6717
CMTM6	3495	-3483
CNN2	2764	1735
COMMD3	-426	-6772
COMMD9	3544	-4811
COPB1	3154	-1329
COTL1	3526	2411
CPNE1	-1012	1274
CPNE3	2335	-2088
CPPED1	3772	-3919
CREG1	4403	-5637
CSNK2B	1389	-998
CSTB	2911	-2676
CTSA	4412	-4847
CTSB	4350	-4209
CTSC	739	1561
CTSD	4381	1642
CTSS	3785	-2958
CTSZ	4137	-6765
CYB5R3	4090	-1540
CYBA	2922	1006
CYFIP1	4295	-6630
CYSTM1	4193	-5233
DBNL	3411	-3713
DEGS1	2496	-193
DERA	3866	-756
DGAT1	2033	-6115
DIAPH1	-283	1033
DNAJC13	3719	-4825
DNAJC3	3828	-2353
DNAJC5	3964	-5119
DPP7	-1381	-1037
DSN1	-3971	369
DYNC1H1	-2492	1504
DYNC1LI1	2930	-2912
DYNLL1	2378	-3319
DYNLT1	1622	1458
EEF1A1	-1549	720
EEF2	90	2127
ENPP4	-3342	-1178
ERP44	2912	1942
FABP5	2411	-3534
FAF2	2168	-4965
FGR	3853	-5292
FTH1	1827	-521
FTL	3957	-4621
FUCA1	3203	-5579
FUCA2	3743	-427
GAA	3545	-3801
GALNS	3034	-854
GCA	4384	-5597
GDI2	3138	-587
GGH	2515	-2788
GHDC	1470	-5520
GLB1	3992	1368
GLIPR1	3403	-2351
GM2A	4180	-825
GMFG	3717	-2699
GNS	4348	-571
GOLGA7	1429	-2970
GPI	2558	-2211
GRN	4323	-4414
GSDMD	614	-3378
GSTP1	35	-5415
GUSB	3389	-4967
GYG1	4157	-5541
HEBP2	3803	-1822
HEXB	4022	-5777
HGSNAT	583	2126
HLA-A	-771	-5991
HLA-B	205	1015
HLA-C	321	-25
HLA-H	-1158	-101
HMGB1	-86	-1263
HMOX2	-4583	2130
HSP90AA1	411	-781
HSP90AB1	-2171	-5745
HSPA1A	3613	-3825
HSPA1B	2669	-513
HVCN1	1834	-217
IDH1	4409	-2333
IGF2R	3062	-5512
ILF2	-597	-3803
IMPDH1	4313	-750
IMPDH2	-3507	446
IQGAP1	3661	1271
IQGAP2	2738	-246
IST1	2328	-3896
ITGAL	-4012	2268
ITGAV	2457	-5201
ITGB2	4114	1322
KCMF1	3480	-3080
KCNAB2	-31	-6014
KPNB1	776	-2176
LAIR1	3084	-6275
LAMP1	3329	-376
LAMTOR1	4371	-5950
LAMTOR2	3287	1882
LAMTOR3	3292	321
LPCAT1	-2399	1540
LTA4H	4292	-972
MAN2B1	2897	-6345
MANBA	3188	1807
MAPK1	3249	1865
MAPK14	4207	-3529
MIF	-1146	-2943
MLEC	737	953
MMP25	3875	1010
MNDA	4303	-6779
MPO	3220	-6776
MVP	2998	-2267
NAPRT	3205	-6164
NBEAL2	3020	-4329
NCKAP1L	3360	-6178
NCSTN	4254	-3821
NDUFC2	2451	-4977
NEU1	4167	-3878
NHLRC3	395	1682
NIT2	-4507	-2140
NME2	576	-4319
NPC2	2118	-712
ORMDL3	-3550	-2716
OSCAR	4186	-4669
OSTF1	3214	1667
P2RX1	3829	-6722
PA2G4	-1166	-175
PAFAH1B2	2931	-1392
PDAP1	2352	-1208
PDXK	3939	-5028
PFKL	-977	-5964
PGAM1	4383	-2347
PGM1	2316	-4799
PGM2	4341	-1959
PKM	4362	-3076
PLAC8	3838	-4418
PLAU	1828	-6512
PLAUR	3822	-6237
PLD1	4321	-6058
PLEKHO2	3605	-3111
PNP	3818	-4436
PPIA	-2133	490
PPIE	-3082	644
PRCP	3695	368
PRDX6	4109	916
PRKCD	4154	584
PRTN3	2825	-6448
PSAP	3061	-4192
PSEN1	3540	-3407
PSMA2	2052	1205
PSMA5	-1869	592
PSMB1	1131	-1179
PSMB7	3856	-2038
PSMC3	624	-4615
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD6	3465	-5488
PSMD7	2383	7
PTGES2	-2198	-1462
PTPN6	2452	-4586
PTPRC	706	-1407
PTPRJ	3428	2365
PTPRN2	1970	2235
PYCARD	3942	-6598
PYGB	152	-5617
QPCT	4331	-6405
QSOX1	4315	-1087
RAB10	4103	-3437
RAB14	3027	1334
RAB18	3438	-1995
RAB24	2063	-3725
RAB27A	3811	-1181
RAB37	-4565	-5384
RAB3A	3646	-1080
RAB3D	4263	-6515
RAB4B	1028	1318
RAB5B	2790	-2055
RAB5C	3953	-1152
RAB6A	3657	-311
RAB7A	4002	-5570
RAC1	4031	971
RAP1A	3148	323
RAP1B	1058	-1031
RAP2B	-248	-2291
RHOA	3753	1313
RHOF	-4879	1911
RHOG	3858	860
RNASET2	2360	2094
ROCK1	3246	-985
S100A11	4118	-1013
S100P	3758	1295
SCAMP1	584	-356
SDCBP	4324	-2535
SERPINB1	4382	-4489
SERPINB6	2324	-5578
SLC11A1	4243	-4413
SLC15A4	1288	-5940
SLC27A2	-1137	-6055
SLC2A3	4160	-4757
SLC44A2	861	2003
SLCO4C1	1061	-1063
SNAP23	3937	-6016
SNAP29	2615	-4157
SPTAN1	-4344	-1250
SRP14	2573	-848
STBD1	2159	-6441
STK10	-1159	-3955
STK11IP	1224	-3840
STOM	2795	-3877
SURF4	3001	1222
SVIP	642	-4596
TBC1D10C	-4609	2261
TCIRG1	3087	-5082
TLR2	4206	-6586
TMBIM1	3776	-1433
TMC6	-3874	2299
TMEM179B	140	276
TMEM30A	3589	-1977
TMEM63A	-3139	-5444
TNFRSF1B	2421	2416
TOLLIP	3905	-5037
TOM1	4259	-5118
TRAPPC1	3441	-3029
TRPM2	4205	-6600
TSPAN14	2946	1366
TUBB	-2209	1395
TUBB4B	3111	1856
TXNDC5	122	-5179
TYROBP	3270	-6720
UNC13D	3311	-6493
VAMP8	1989	-6050
VAPA	4169	-5592
VAT1	4302	-3481
VCL	3157	-5870
VCP	2902	-2411
XRCC5	2075	-3770
XRCC6	-1335	376
YPEL5	2788	-1479

---

---

Innate Immune System

Innate Immune System

metric	value
setSize	616
pMANOVA	1.27e-46
p.adjustMANOVA	7.4e-44
s.dist	0.348
s.RNA	0.348
s.meth	-0.0137
p.RNA	8.51e-48
p.meth	0.57

Top 20 genes

Gene	RNA	meth
CKAP4	4355	-6717
MNDA	4303	-6779
NCF4	4298	-6732
CYFIP1	4295	-6630
CTSZ	4137	-6765
RAB3D	4263	-6515
TRPM2	4205	-6600
QPCT	4331	-6405
TLR2	4206	-6586
IRAK3	4208	-6295
PRKACA	4378	-6032
PLD1	4321	-6058
PYCARD	3942	-6598
LAMTOR1	4371	-5950
NLRP3	4089	-6357
BRI3	4159	-6229
P2RX1	3829	-6722
ATP6V0A1	4375	-5877
ALOX5	4150	-6082
RNF135	3897	-6458

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2170	-3533
AAMP	-1084	-5298
ABI1	3018	-1788
ABI2	-4048	-5451
ABL1	63	-4891
ACAA1	3734	1410
ACLY	1961	-5417
ACTB	4156	-4515
ACTG1	3901	1793
ACTR10	3309	-1291
ACTR1B	-3828	-3653
ACTR2	3481	-3374
ACTR3	3448	-2917
ADAM10	4030	976
ADAM8	2208	-5902
ADGRE5	-769	-5511
AGA	-1396	-2458
AGL	-940	-3188
AGPAT2	4289	2250
AHCYL1	2658	-3553
AIM2	-522	-3997
ALAD	3874	-1369
ALDOA	4285	-1349
ALDOC	-1028	-6226
ALOX5	4150	-6082
AMPD3	3997	-5620
ANO6	3597	-3634
AP1M1	2798	-2408
APAF1	4158	-2104
APEH	314	1724
APP	4249	-5300
APRT	-834	-204
ARHGAP9	2545	2156
ARL8A	3713	-6230
ARMC8	2620	-1033
ARPC1B	4291	-2022
ARPC2	3191	-3647
ARPC3	3729	-3767
ARPC5	3968	-3837
ARSA	1183	-3099
ARSB	3290	-5722
ASAH1	3880	335
ATAD3B	-3588	-1948
ATF1	2245	-2565
ATG12	-247	-111
ATG5	429	-2626
ATG7	3647	569
ATOX1	1562	-5343
ATP11A	3801	-5671
ATP11B	2429	1806
ATP6V0A1	4375	-5877
ATP6V0A2	-4811	689
ATP6V0B	3921	1604
ATP6V0C	4218	-4697
ATP6V0D1	4282	-1003
ATP6V0E1	3919	-2865
ATP6V0E2	-4420	-6625
ATP6V1A	4318	1580
ATP6V1B2	4178	-4232
ATP6V1C1	3887	655
ATP6V1D	4174	-1234
ATP6V1E1	3588	-3948
ATP6V1F	2338	1350
ATP6V1G2	-3312	-3714
ATP6V1H	3607	-1695
ATP8A1	-4599	-250
ATP8B4	2945	1090
B2M	-2195	-2389
B4GALT1	1540	-160
BAIAP2	-72	1977
BCL10	2320	-3261
BCL2	-1421	2361
BCL2L1	3979	1306
BIN2	2264	-2805
BIRC2	1737	-1862
BIRC3	-4159	-2320
BRI3	4159	-6229
BRK1	2983	1970
BST2	-2378	-1970
BTRC	-1493	-2427
C3AR1	3573	-6729
C6orf120	2508	1218
C8G	-4476	397
CAB39	3728	-2802
CALM1	-626	-5019
CAND1	-2041	-421
CAP1	3635	-553
CAPN1	3902	-6119
CAPZA1	3648	572
CAPZA2	3920	-36
CARD11	-4781	851
CARD9	2767	-6197
CASP1	1501	-1448
CASP10	-1032	-6612
CASP4	2359	-5184
CASP8	-4285	387
CASP9	3366	-234
CAT	4214	-3922
CCT2	-3002	-727
CCT8	2708	-1245
CD247	-4880	2098
CD300A	-641	-6466
CD4	-1648	-6372
CD44	3760	266
CD46	2321	-4098
CD47	-4754	-114
CD53	3492	2243
CD55	4229	-3923
CD58	2766	-3228
CD59	2326	-6024
CD63	4308	-1017
CD81	-3185	-4830
CDC34	3927	-2454
CDC42	3268	-2719
CDK13	-2814	-700
CEACAM1	3825	-5827
CEP290	-3161	-2056
CFL1	3683	912
CHUK	3543	1343
CKAP4	4355	-6717
CMTM6	3495	-3483
CNN2	2764	1735
CNPY3	3416	-3161
COMMD3	-426	-6772
COMMD9	3544	-4811
COPB1	3154	-1329
COTL1	3526	2411
CPNE1	-1012	1274
CPNE3	2335	-2088
CPPED1	3772	-3919
CRCP	1795	-577
CREB1	-430	-672
CREBBP	1153	-5804
CREG1	4403	-5637
CRK	4091	-4581
CSNK2B	1389	-998
CSTB	2911	-2676
CTNNB1	2626	-1691
CTSA	4412	-4847
CTSB	4350	-4209
CTSC	739	1561
CTSD	4381	1642
CTSL	1504	-6671
CTSS	3785	-2958
CTSV	-910	-5834
CTSZ	4137	-6765
CUL1	-4281	-5146
CYB5R3	4090	-1540
CYBA	2922	1006
CYFIP1	4295	-6630
CYFIP2	-3754	2232
CYLD	-3240	1406
CYSTM1	4193	-5233
DBNL	3411	-3713
DDX41	1154	-118
DDX58	-4651	-1002
DEGS1	2496	-193
DERA	3866	-756
DGAT1	2033	-6115
DHX36	-1599	2251
DHX58	-4588	-5666
DHX9	322	871
DIAPH1	-283	1033
DNAJC13	3719	-4825
DNAJC3	3828	-2353
DNAJC5	3964	-5119
DNM1	1225	-5619
DNM2	2448	738
DPP7	-1381	-1037
DSN1	-3971	369
DTX4	2486	1530
DUSP3	4305	-1798
DUSP4	-1957	-3176
DUSP6	1570	-6763
DUSP7	-960	-1322
DYNC1H1	-2492	1504
DYNC1LI1	2930	-2912
DYNLL1	2378	-3319
DYNLT1	1622	1458
ECSIT	1839	-4938
EEA1	1708	-711
EEF1A1	-1549	720
EEF2	90	2127
ELMO1	2547	-2714
ELMO2	1591	1326
ENPP4	-3342	-1178
EP300	2471	-4509
ERP44	2912	1942
FABP5	2411	-3534
FADD	2211	-6328
FAF2	2168	-4965
FBXW11	2510	-6747
FGR	3853	-5292
FOS	2120	2149
FTH1	1827	-521
FTL	3957	-4621
FUCA1	3203	-5579
FUCA2	3743	-427
FYN	-4495	1957
GAA	3545	-3801
GAB2	3629	-6153
GALNS	3034	-854
GCA	4384	-5597
GDI2	3138	-587
GGH	2515	-2788
GHDC	1470	-5520
GLB1	3992	1368
GLIPR1	3403	-2351
GM2A	4180	-825
GMFG	3717	-2699
GNS	4348	-571
GOLGA7	1429	-2970
GPI	2558	-2211
GRAP2	1736	-5763
GRB2	4320	-2295
GRN	4323	-4414
GSDMD	614	-3378
GSTP1	35	-5415
GUSB	3389	-4967
GYG1	4157	-5541
GZMM	-4597	2516
HEBP2	3803	-1822
HERC5	-4820	-6136
HEXB	4022	-5777
HGSNAT	583	2126
HLA-A	-771	-5991
HLA-B	205	1015
HLA-C	321	-25
HLA-E	-1317	-2213
HLA-H	-1158	-101
HMGB1	-86	-1263
HMOX2	-4583	2130
HRAS	-1008	-4780
HSP90AA1	411	-781
HSP90AB1	-2171	-5745
HSP90B1	647	-1371
HSPA1A	3613	-3825
HSPA1B	2669	-513
HVCN1	1834	-217
ICAM2	-4698	427
ICAM3	3443	2137
IDH1	4409	-2333
IFIH1	-4282	-4856
IGF2R	3062	-5512
IKBKB	-1640	-3894
IKBKE	1750	2086
ILF2	-597	-3803
IMPDH1	4313	-750
IMPDH2	-3507	446
IQGAP1	3661	1271
IQGAP2	2738	-246
IRAK2	-3327	-1457
IRAK3	4208	-6295
IRF3	-2870	542
IRF7	-2922	1622
ISG15	-4701	1894
IST1	2328	-3896
ITCH	407	-1366
ITGAL	-4012	2268
ITGAV	2457	-5201
ITGB2	4114	1322
ITK	-4214	-6507
ITPR1	-2478	-3278
ITPR2	2315	-6107
ITPR3	-3717	-3427
JUN	1286	69
KCMF1	3480	-3080
KCNAB2	-31	-6014
KPNB1	776	-2176
KRAS	1276	440
LAIR1	3084	-6275
LAMP1	3329	-376
LAMTOR1	4371	-5950
LAMTOR2	3287	1882
LAMTOR3	3292	321
LAT2	4033	-5840
LCK	-4596	2489
LCP2	-363	1588
LGMN	-1401	313
LIMK1	1730	-3787
LPCAT1	-2399	1540
LRRFIP1	2568	-1040
LTA4H	4292	-972
MALT1	-4051	-2968
MAN2B1	2897	-6345
MANBA	3188	1807
MAP2K1	4183	-698
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAP3K1	1942	-176
MAP3K14	-4512	-2542
MAP3K7	761	-2089
MAP3K8	2489	1442
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPK8	-3265	6
MAPK9	-2259	872
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MAVS	3048	-4500
MEF2A	3571	-2822
MIF	-1146	-2943
MLEC	737	953
MMP25	3875	1010
MNDA	4303	-6779
MPO	3220	-6776
MUC1	2718	-5557
MUC12	-3930	-5807
MUC5B	-1389	2353
MVP	2998	-2267
MYD88	3649	-1927
MYH9	2789	2182
MYO9B	2637	687
NAPRT	3205	-6164
NBEAL2	3020	-4329
NCF4	4298	-6732
NCK1	-4361	-1408
NCKAP1L	3360	-6178
NCKIPSD	97	-4332
NCSTN	4254	-3821
NDUFC2	2451	-4977
NEU1	4167	-3878
NF2	-2034	-2754
NFATC1	-3145	2372
NFATC2	-4851	2414
NFATC3	-4790	92
NFKB2	-367	388
NFKBIA	2851	1159
NFKBIB	-48	-3368
NHLRC3	395	1682
NIT2	-4507	-2140
NKIRAS1	116	-3490
NKIRAS2	4346	-5039
NLRC5	-3726	1646
NLRP1	-1972	-5049
NLRP3	4089	-6357
NLRX1	3451	-2858
NME2	576	-4319
NOD1	-4837	-5170
NOD2	3833	1528
NOS3	-620	-1770
NPC2	2118	-712
ORMDL3	-3550	-2716
OSCAR	4186	-4669
OSTF1	3214	1667
P2RX1	3829	-6722
PA2G4	-1166	-175
PAFAH1B2	2931	-1392
PAK1	3703	-3995
PAK2	3682	-3961
PANX1	2552	1595
PCBP2	2027	132
PDAP1	2352	-1208
PDPK1	2474	167
PDXK	3939	-5028
PELI1	2800	-3839
PELI2	3750	-2561
PELI3	3383	-4323
PFKL	-977	-5964
PGAM1	4383	-2347
PGM1	2316	-4799
PGM2	4341	-1959
PIK3CA	1703	-1445
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R4	-1215	-3425
PIN1	-955	-1656
PKM	4362	-3076
PLA2G6	-4758	-3132
PLAC8	3838	-4418
PLAU	1828	-6512
PLAUR	3822	-6237
PLCG1	-4158	-3541
PLCG2	1884	-2562
PLD1	4321	-6058
PLD3	3177	1541
PLEKHO2	3605	-3111
PNP	3818	-4436
POLR1C	-4039	-2688
POLR1D	2715	-2500
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2H	-882	1944
POLR2K	-537	-2424
POLR3A	-2354	2213
POLR3C	-2396	509
POLR3D	-4557	1264
POLR3E	-4318	-673
POLR3F	-1579	-5523
POLR3G	-1645	1201
POLR3GL	-2424	-6348
POLR3H	-3719	-510
POLR3K	-737	1383
PPIA	-2133	490
PPIE	-3082	644
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5D	771	-4349
PPP3CA	2522	-2165
PPP3CB	2968	517
PPP3R1	3675	-3276
PRCP	3695	368
PRDX6	4109	916
PRKACA	4378	-6032
PRKACB	-4656	455
PRKCD	4154	584
PRKCE	-2638	-5632
PRKCQ	-4762	1372
PRKCSH	1991	-3007
PRKDC	-3668	1316
PRTN3	2825	-6448
PSAP	3061	-4192
PSEN1	3540	-3407
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PSTPIP1	3462	1135
PTGES2	-2198	-1462
PTK2	1629	920
PTPN11	2038	-2302
PTPN4	-4818	-3156
PTPN6	2452	-4586
PTPRC	706	-1407
PTPRJ	3428	2365
PTPRN2	1970	2235
PYCARD	3942	-6598
PYGB	152	-5617
QPCT	4331	-6405
QSOX1	4315	-1087
RAB10	4103	-3437
RAB14	3027	1334
RAB18	3438	-1995
RAB24	2063	-3725
RAB27A	3811	-1181
RAB37	-4565	-5384
RAB3A	3646	-1080
RAB3D	4263	-6515
RAB4B	1028	1318
RAB5B	2790	-2055
RAB5C	3953	-1152
RAB6A	3657	-311
RAB7A	4002	-5570
RAC1	4031	971
RAC2	1962	-868
RAF1	3488	-314
RAP1A	3148	323
RAP1B	1058	-1031
RAP2B	-248	-2291
RASGRP1	-4668	2119
RASGRP2	-2873	1508
RBSN	-1363	-2813
RELA	-542	2085
RELB	1285	-5206
RHOA	3753	1313
RHOF	-4879	1911
RHOG	3858	860
RIPK3	1497	-370
RNASET2	2360	2094
RNF125	-4197	-1762
RNF135	3897	-6458
RNF216	-3839	201
ROCK1	3246	-985
RPS27A	-2201	-2138
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA5	-4445	-514
S100A11	4118	-1013
S100P	3758	1295
SARM1	-4766	-5412
SCAMP1	584	-356
SDCBP	4324	-2535
SERPINB1	4382	-4489
SERPINB6	2324	-5578
SHC1	1472	-2954
SIGIRR	-3958	290
SIKE1	-2255	-1187
SKP1	1536	-2290
SLC11A1	4243	-4413
SLC15A4	1288	-5940
SLC27A2	-1137	-6055
SLC2A3	4160	-4757
SLC44A2	861	2003
SLCO4C1	1061	-1063
SNAP23	3937	-6016
SNAP29	2615	-4157
SOCS1	1375	-2999
SOS1	-1748	-6775
SPTAN1	-4344	-1250
SRC	-2999	-4427
SRP14	2573	-848
STAT6	2340	-3911
STBD1	2159	-6441
STK10	-1159	-3955
STK11IP	1224	-3840
STOM	2795	-3877
SUGT1	475	594
SURF4	3001	1222
SVIP	642	-4596
SYK	4192	-5054
TAB2	2942	1892
TANK	3251	-1331
TAX1BP1	2418	-4470
TBC1D10C	-4609	2261
TBK1	1067	-4616
TCIRG1	3087	-5082
TEC	3276	-5839
TICAM1	2569	-2136
TIFA	1905	-1726
TIRAP	2210	-5182
TLR1	4106	-6127
TLR2	4206	-6586
TLR3	-4406	-5820
TLR5	4260	1823
TLR6	4058	-802
TLR9	-1850	2292
TMBIM1	3776	-1433
TMC6	-3874	2299
TMEM179B	140	276
TMEM30A	3589	-1977
TMEM63A	-3139	-5444
TNFAIP3	-4067	-785
TNFRSF1B	2421	2416
TNIP2	2166	-5726
TOLLIP	3905	-5037
TOM1	4259	-5118
TRAF2	-4539	-1442
TRAF3	-1701	2379
TRAF6	-80	-6118
TRAPPC1	3441	-3029
TREX1	-377	-5868
TRIM21	775	-6370
TRIM25	3700	-3718
TRIM56	-2958	141
TRPM2	4205	-6600
TSPAN14	2946	1366
TUBB	-2209	1395
TUBB4B	3111	1856
TXK	-4496	170
TXN	3732	284
TXNDC5	122	-5179
TXNIP	-3347	-2777
TYROBP	3270	-6720
UBA3	3420	-2122
UBA52	349	752
UBA7	-2452	-6667
UBB	2759	-1321
UBC	1618	-2568
UBE2D1	4255	-1581
UBE2D2	1717	-3799
UBE2D3	3944	-373
UBE2K	2901	1379
UBE2L6	-4256	-4206
UBE2M	3239	-3585
UBE2N	607	1127
UBE2V1	2209	-1021
UNC13D	3311	-6493
UNC93B1	1479	-4358
VAMP8	1989	-6050
VAPA	4169	-5592
VAT1	4302	-3481
VAV1	3499	-3184
VAV2	-1214	-643
VAV3	1824	-6342
VCL	3157	-5870
VCP	2902	-2411
VRK3	396	-1398
VTN	-613	2265
WASF1	4414	-1056
WASF2	3782	-2654
WASL	87	-4742
WIPF1	177	-4382
WIPF2	2249	-2523
XRCC5	2075	-3770
XRCC6	-1335	376
YES1	-4772	-4415
YPEL5	2788	-1479
ZBP1	-4869	-410

---

---

Immune System

Immune System

metric	value
setSize	1142
pMANOVA	2.01e-30
p.adjustMANOVA	7.78e-28
s.dist	0.208
s.RNA	0.202
s.meth	0.0493
p.RNA	1.16e-28
p.meth	0.00686

Top 20 genes

Gene	RNA	meth
CLTC	4149	2477
AGPAT2	4289	2250
SOCS3	4399	2178
SIAH2	3910	2185
COTL1	3526	2411
PTPRJ	3428	2365
CD53	3492	2243
TLR5	4260	1823
LCP1	3793	2024
ICAM3	3443	2137
SLA	3335	2206
CTSD	4381	1642
EIF4E3	3286	2181
IL19	2820	2517
ACTG1	3901	1793
ATP6V1A	4318	1580
RNF123	2846	2363
ATP6V0B	3921	1604
LAMTOR2	3287	1882
MYH9	2789	2182

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2170	-3533
AAAS	-2812	405
AAMP	-1084	-5298
ABCE1	-3946	-1384
ABI1	3018	-1788
ABI2	-4048	-5451
ABL1	63	-4891
ABL2	1565	301
ACAA1	3734	1410
ACLY	1961	-5417
ACTB	4156	-4515
ACTG1	3901	1793
ACTR10	3309	-1291
ACTR1A	2965	-1
ACTR1B	-3828	-3653
ACTR2	3481	-3374
ACTR3	3448	-2917
ADAM10	4030	976
ADAM17	3634	774
ADAM8	2208	-5902
ADAR	-1029	-263
ADGRE5	-769	-5511
AGA	-1396	-2458
AGL	-940	-3188
AGPAT2	4289	2250
AHCYL1	2658	-3553
AIM2	-522	-3997
AIP	-1061	1761
AKT1	1234	-1942
AKT2	133	-141
ALAD	3874	-1369
ALDOA	4285	-1349
ALDOC	-1028	-6226
ALOX5	4150	-6082
AMPD3	3997	-5620
ANAPC1	-4659	403
ANAPC10	-1520	-6111
ANAPC11	2490	344
ANAPC13	941	-1507
ANAPC2	-2390	-1007
ANAPC4	-2075	-1696
ANAPC5	-4080	-2530
ANAPC7	-1573	1560
ANO6	3597	-3634
AP1B1	3995	-463
AP1G1	1397	516
AP1M1	2798	-2408
AP1S3	-1681	-5455
AP2A1	2869	-4887
AP2M1	3936	20
AP2S1	3581	-3262
APAF1	4158	-2104
APEH	314	1724
APP	4249	-5300
APRT	-834	-204
AREL1	2666	-139
ARF1	4184	-6686
ARHGAP9	2545	2156
ARIH1	-679	-323
ARIH2	-4739	846
ARL8A	3713	-6230
ARMC8	2620	-1033
ARPC1B	4291	-2022
ARPC2	3191	-3647
ARPC3	3729	-3767
ARPC5	3968	-3837
ARSA	1183	-3099
ARSB	3290	-5722
ASAH1	3880	335
ASB1	1105	1900
ASB13	1106	-5265
ASB2	-4671	-2230
ASB6	-832	-6098
ASB7	2524	-4653
ASB8	1819	998
ATAD3B	-3588	-1948
ATF1	2245	-2565
ATG12	-247	-111
ATG5	429	-2626
ATG7	3647	569
ATOX1	1562	-5343
ATP11A	3801	-5671
ATP11B	2429	1806
ATP6V0A1	4375	-5877
ATP6V0A2	-4811	689
ATP6V0B	3921	1604
ATP6V0C	4218	-4697
ATP6V0D1	4282	-1003
ATP6V0E1	3919	-2865
ATP6V0E2	-4420	-6625
ATP6V1A	4318	1580
ATP6V1B2	4178	-4232
ATP6V1C1	3887	655
ATP6V1D	4174	-1234
ATP6V1E1	3588	-3948
ATP6V1F	2338	1350
ATP6V1G2	-3312	-3714
ATP6V1H	3607	-1695
ATP8A1	-4599	-250
ATP8B4	2945	1090
B2M	-2195	-2389
B4GALT1	1540	-160
BAIAP2	-72	1977
BATF	2612	2070
BCL10	2320	-3261
BCL2	-1421	2361
BCL2L1	3979	1306
BCL2L11	3187	1781
BCL6	4248	-299
BIN2	2264	-2805
BIRC2	1737	-1862
BIRC3	-4159	-2320
BIRC5	1291	-84
BLMH	980	-515
BRI3	4159	-6229
BRK1	2983	1970
BRWD1	-3183	-3884
BST2	-2378	-1970
BTBD1	715	-5321
BTBD6	-1584	-136
BTN2A1	-2813	-107
BTN2A2	-4532	-893
BTN3A1	-4889	1435
BTN3A2	-4647	599
BTN3A3	-4877	2244
BTRC	-1493	-2427
C3AR1	3573	-6729
C6orf120	2508	1218
C8G	-4476	397
CAB39	3728	-2802
CALM1	-626	-5019
CALR	2586	-3753
CAMK2D	-4581	-2867
CAMK2G	601	2354
CAND1	-2041	-421
CANX	2151	-4839
CAP1	3635	-553
CAPN1	3902	-6119
CAPZA1	3648	572
CAPZA2	3920	-36
CAPZB	3576	-4065
CARD11	-4781	851
CARD9	2767	-6197
CASP1	1501	-1448
CASP10	-1032	-6612
CASP3	-208	-2764
CASP4	2359	-5184
CASP8	-4285	387
CASP9	3366	-234
CAT	4214	-3922
CBL	3241	1456
CBLB	-4856	-840
CCND1	-2214	-6213
CCNF	-3202	-4258
CCR1	4074	-6480
CCT2	-3002	-727
CCT8	2708	-1245
CD247	-4880	2098
CD274	-2456	-296
CD300A	-641	-6466
CD3D	-4327	2493
CD3E	-4258	2442
CD4	-1648	-6372
CD44	3760	266
CD46	2321	-4098
CD47	-4754	-114
CD53	3492	2243
CD55	4229	-3923
CD58	2766	-3228
CD59	2326	-6024
CD63	4308	-1017
CD74	-4340	-4283
CD79B	-2407	-6685
CD81	-3185	-4830
CD96	-4743	2283
CDC16	-1877	-4152
CDC20	1401	116
CDC23	-4259	-707
CDC34	3927	-2454
CDC42	3268	-2719
CDK13	-2814	-700
CDKN1A	1646	-3540
CDKN1B	-2723	-862
CEACAM1	3825	-5827
CEBPD	4044	-5142
CENPE	98	-4165
CEP290	-3161	-2056
CFL1	3683	912
CHUK	3543	1343
CISH	1836	1748
CKAP4	4355	-6717
CLEC2B	-3043	-4871
CLTA	3788	-5077
CLTC	4149	2477
CMTM6	3495	-3483
CNN2	2764	1735
CNPY3	3416	-3161
COMMD3	-426	-6772
COMMD9	3544	-4811
COPB1	3154	-1329
COTL1	3526	2411
CPNE1	-1012	1274
CPNE3	2335	-2088
CPPED1	3772	-3919
CRCP	1795	-577
CREB1	-430	-672
CREBBP	1153	-5804
CREG1	4403	-5637
CRK	4091	-4581
CRKL	1387	-906
CSF1	-622	-5924
CSK	1990	862
CSNK2B	1389	-998
CSTB	2911	-2676
CTF1	1521	-5738
CTLA4	-3751	2506
CTNNB1	2626	-1691
CTSA	4412	-4847
CTSB	4350	-4209
CTSC	739	1561
CTSD	4381	1642
CTSL	1504	-6671
CTSO	-4305	1113
CTSS	3785	-2958
CTSV	-910	-5834
CTSZ	4137	-6765
CUL1	-4281	-5146
CUL2	805	-1212
CUL3	2861	2054
CUL5	265	-3077
CUL7	-995	-2524
CXCL2	2093	-6755
CYB5R3	4090	-1540
CYBA	2922	1006
CYFIP1	4295	-6630
CYFIP2	-3754	2232
CYLD	-3240	1406
CYSTM1	4193	-5233
DAPP1	2125	279
DBNL	3411	-3713
DCTN2	4235	-6011
DCTN3	2396	-4272
DCTN4	3796	-2073
DCTN5	-1222	-5100
DCTN6	3145	819
DDX41	1154	-118
DDX58	-4651	-1002
DEGS1	2496	-193
DERA	3866	-756
DET1	-3172	978
DGAT1	2033	-6115
DHX36	-1599	2251
DHX58	-4588	-5666
DHX9	322	871
DIAPH1	-283	1033
DNAJC13	3719	-4825
DNAJC3	3828	-2353
DNAJC5	3964	-5119
DNM1	1225	-5619
DNM2	2448	738
DPP7	-1381	-1037
DSN1	-3971	369
DTX4	2486	1530
DUSP3	4305	-1798
DUSP4	-1957	-3176
DUSP6	1570	-6763
DUSP7	-960	-1322
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNLL1	2378	-3319
DYNLL2	-1189	214
DYNLT1	1622	1458
DZIP3	-4106	-5113
ECSIT	1839	-4938
EDARADD	-4064	1906
EEA1	1708	-711
EEF1A1	-1549	720
EEF2	90	2127
EGR1	1023	-163
EIF2AK2	-3128	-3645
EIF4A1	3303	-3762
EIF4A2	-4175	836
EIF4A3	3132	-3850
EIF4E	1789	1536
EIF4E2	3181	1473
EIF4E3	3286	2181
EIF4G1	3585	746
EIF4G2	2920	-3101
EIF4G3	3804	-3868
ELMO1	2547	-2714
ELMO2	1591	1326
ENPP4	-3342	-1178
EP300	2471	-4509
ERAP1	-2372	-1887
ERAP2	-1627	-1261
ERP44	2912	1942
EVL	-4808	2303
FABP5	2411	-3534
FADD	2211	-6328
FAF2	2168	-4965
FBXL12	-407	292
FBXL14	-1899	2358
FBXL15	1641	-4502
FBXL16	-2077	-4011
FBXL18	1098	-5248
FBXL19	3931	-6239
FBXL20	1804	-993
FBXL22	-3179	562
FBXL3	318	-4101
FBXL4	2136	-5130
FBXL5	4370	-6189
FBXL8	1413	-479
FBXO11	2793	-500
FBXO15	-394	647
FBXO21	-3979	-933
FBXO22	-1105	1132
FBXO30	1733	-609
FBXO31	-4652	480
FBXO32	-3875	-1875
FBXO4	-4600	-4056
FBXO6	-687	234
FBXO7	3250	-3059
FBXO9	4374	-3674
FBXW11	2510	-6747
FBXW2	2712	-3711
FBXW4	-4543	1993
FBXW5	76	-194
FBXW7	-2055	-5428
FBXW8	-3557	-2504
FGR	3853	-5292
FKBP1A	4177	-4465
FLNB	536	1550
FLT3LG	-3495	1573
FOS	2120	2149
FOXO1	-3290	-5036
FOXO3	3966	711
FTH1	1827	-521
FTL	3957	-4621
FUCA1	3203	-5579
FUCA2	3743	-427
FYN	-4495	1957
FZR1	-670	-758
GAA	3545	-3801
GAB2	3629	-6153
GALNS	3034	-854
GAN	-440	-2479
GATA3	-4799	1861
GBP3	-3069	-3362
GCA	4384	-5597
GDI2	3138	-587
GGH	2515	-2788
GHDC	1470	-5520
GLB1	3992	1368
GLIPR1	3403	-2351
GLMN	-4133	2117
GM2A	4180	-825
GMFG	3717	-2699
GNS	4348	-571
GOLGA7	1429	-2970
GPI	2558	-2211
GRAP2	1736	-5763
GRB10	4386	-70
GRB2	4320	-2295
GRN	4323	-4414
GSDMD	614	-3378
GSTO1	4196	-170
GSTP1	35	-5415
GUSB	3389	-4967
GYG1	4157	-5541
GZMM	-4597	2516
HACE1	-1806	-6052
HCST	-1569	1737
HEBP2	3803	-1822
HECTD1	-744	-2953
HECTD3	377	-6086
HERC1	-3213	-1142
HERC3	319	-2583
HERC4	1825	-2430
HERC5	-4820	-6136
HEXB	4022	-5777
HGSNAT	583	2126
HIF1A	3219	-3349
HLA-A	-771	-5991
HLA-B	205	1015
HLA-C	321	-25
HLA-DMA	-3490	-6628
HLA-E	-1317	-2213
HLA-F	-4165	1671
HLA-H	-1158	-101
HMGB1	-86	-1263
HMOX2	-4583	2130
HNRNPA2B1	1133	-2665
HNRNPF	1366	-58
HRAS	-1008	-4780
HSP90AA1	411	-781
HSP90AB1	-2171	-5745
HSP90B1	647	-1371
HSPA1A	3613	-3825
HSPA1B	2669	-513
HSPA9	-3436	-200
HVCN1	1834	-217
ICAM1	2796	-5333
ICAM2	-4698	427
ICAM3	3443	2137
ICAM5	3528	-5930
ICOSLG	-2168	-4532
IDH1	4409	-2333
IFI30	3367	-6228
IFI35	-1735	-1569
IFI6	-4620	-2830
IFIH1	-4282	-4856
IFIT1	-4864	-4377
IFIT2	-4749	-5574
IFIT3	-4705	-2035
IFIT5	-4254	-90
IFITM1	-1947	2403
IFNAR1	3813	-490
IFNAR2	2778	-3573
IFNGR1	4301	310
IFNGR2	4279	-6331
IGF2R	3062	-5512
IKBKB	-1640	-3894
IKBKE	1750	2086
IL10RA	-3866	1263
IL10RB	4239	-6138
IL12A	-2552	-5748
IL12RB1	-4755	-1444
IL12RB2	-4683	-5603
IL15	-1531	-5098
IL15RA	826	-3679
IL16	-3409	656
IL17C	-2074	-1115
IL17RA	4257	-3604
IL17RC	55	-1157
IL18BP	-3851	-5936
IL18R1	1399	475
IL19	2820	2517
IL1RAP	3063	-456
IL21R	-4834	401
IL23A	-3838	-6478
IL27RA	1165	-1230
IL2RA	-2295	-6462
IL2RB	-4882	2472
IL32	-3617	2512
IL4R	3174	-4452
IL6R	3645	-6410
IL6ST	1415	1094
ILF2	-597	-3803
IMPDH1	4313	-750
IMPDH2	-3507	446
INPP5D	-1207	-3735
INPPL1	4166	-2224
IP6K2	-3901	-878
IQGAP1	3661	1271
IQGAP2	2738	-246
IRAK2	-3327	-1457
IRAK3	4208	-6295
IRF1	-2866	1887
IRF2	2640	-2044
IRF3	-2870	542
IRF4	-3062	1782
IRF5	2684	-6572
IRF7	-2922	1622
IRF9	-4174	-4118
IRS1	533	-4060
IRS2	3903	-5410
ISG15	-4701	1894
ISG20	-4455	2340
IST1	2328	-3896
ITCH	407	-1366
ITGA4	-4122	1419
ITGAL	-4012	2268
ITGAV	2457	-5201
ITGB2	4114	1322
ITGB7	-4797	-6402
ITK	-4214	-6507
ITPR1	-2478	-3278
ITPR2	2315	-6107
ITPR3	-3717	-3427
JAK1	-4072	-1022
JAK2	857	-1751
JUN	1286	69
JUNB	2850	-3031
KBTBD6	870	327
KBTBD7	2608	-1326
KBTBD8	-1262	-4094
KCMF1	3480	-3080
KCNAB2	-31	-6014
KCTD6	1579	886
KCTD7	-4415	-602
KEAP1	1826	-2872
KIF11	250	-4751
KIF15	-968	-563
KIF18A	-823	-2125
KIF20A	1931	-231
KIF22	-4887	-1801
KIF23	2143	-3340
KIF2A	-340	1788
KIF2C	229	-1625
KIF3A	-4667	-2118
KIF3B	1292	-2584
KIF3C	3745	-5135
KIF5B	3711	-3520
KIFAP3	-2906	1836
KLC1	2149	-1283
KLC2	-3106	-5681
KLC4	-2808	-4132
KLHL11	-1956	186
KLHL2	4247	-4276
KLHL20	-4381	-2781
KLHL21	1909	-1243
KLHL22	-4331	-899
KLHL25	-3912	-464
KLHL5	1936	-4208
KPNA1	400	-2889
KPNA2	-2190	-874
KPNA3	295	-897
KPNA4	1858	1716
KPNA5	-4625	-572
KPNB1	776	-2176
KRAS	1276	440
LAIR1	3084	-6275
LAMP1	3329	-376
LAMTOR1	4371	-5950
LAMTOR2	3287	1882
LAMTOR3	3292	321
LAT2	4033	-5840
LCK	-4596	2489
LCP1	3793	2024
LCP2	-363	1588
LGALS9	979	-6589
LGMN	-1401	313
LIMK1	1730	-3787
LMNB1	4342	-942
LMO7	-3402	2419
LNPEP	-3357	-478
LONRF1	1658	-187
LPCAT1	-2399	1540
LRR1	-2482	1362
LRRC41	3257	404
LRRFIP1	2568	-1040
LRSAM1	1798	-530
LTA	-3469	2525
LTA4H	4292	-972
LTB	-2823	1685
LTN1	-781	2476
MALT1	-4051	-2968
MAN2B1	2897	-6345
MANBA	3188	1807
MAP2K1	4183	-698
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAP3K1	1942	-176
MAP3K14	-4512	-2542
MAP3K3	3850	64
MAP3K7	761	-2089
MAP3K8	2489	1442
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPK8	-3265	6
MAPK9	-2259	872
MAPKAP1	1911	1057
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MAVS	3048	-4500
MEF2A	3571	-2822
MEX3C	-4774	-2068
MGRN1	2290	-6360
MICA	-1592	-2075
MICB	749	922
MIF	-1146	-2943
MKRN1	4045	-2133
MLEC	737	953
MLST8	117	287
MMP25	3875	1010
MNDA	4303	-6779
MPO	3220	-6776
MRC2	-53	-6280
MT2A	-2224	1556
MTAP	-1778	-5878
MTOR	-3429	-1813
MUC1	2718	-5557
MUC12	-3930	-5807
MUC5B	-1389	2353
MVP	2998	-2267
MX1	-4769	-5375
MX2	-1727	-1978
MYD88	3649	-1927
MYH9	2789	2182
MYLIP	-1191	-681
MYO9B	2637	687
NAPRT	3205	-6164
NBEAL2	3020	-4329
NCF4	4298	-6732
NCK1	-4361	-1408
NCKAP1L	3360	-6178
NCKIPSD	97	-4332
NCSTN	4254	-3821
NDC1	-4789	-5228
NDUFC2	2451	-4977
NEDD4	2511	-5611
NEDD4L	3485	-5066
NEU1	4167	-3878
NF2	-2034	-2754
NFATC1	-3145	2372
NFATC2	-4851	2414
NFATC3	-4790	92
NFKB2	-367	388
NFKBIA	2851	1159
NFKBIB	-48	-3368
NFKBIE	-1637	1607
NHLRC3	395	1682
NIT2	-4507	-2140
NKIRAS1	116	-3490
NKIRAS2	4346	-5039
NLRC5	-3726	1646
NLRP1	-1972	-5049
NLRP3	4089	-6357
NLRX1	3451	-2858
NME2	576	-4319
NOD1	-4837	-5170
NOD2	3833	1528
NOS3	-620	-1770
NPC2	2118	-712
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
OAS1	-3339	-5215
OAS2	-4765	2093
OAS3	-4798	-5833
OASL	-4007	-2933
ORAI1	-2269	-4764
ORAI2	2405	-4356
ORMDL3	-3550	-2716
OSCAR	4186	-4669
OSM	3426	-3652
OSTF1	3214	1667
P2RX1	3829	-6722
P4HB	3831	-1549
PA2G4	-1166	-175
PAFAH1B2	2931	-1392
PAG1	2019	262
PAK1	3703	-3995
PAK2	3682	-3961
PANX1	2552	1595
PCBP2	2027	132
PDAP1	2352	-1208
PDCD4	-4586	1941
PDE12	-1960	1354
PDIA3	1451	1466
PDPK1	2474	167
PDXK	3939	-5028
PELI1	2800	-3839
PELI2	3750	-2561
PELI3	3383	-4323
PFKL	-977	-5964
PGAM1	4383	-2347
PGM1	2316	-4799
PGM2	4341	-1959
PIAS1	3175	-2534
PIK3AP1	3445	-4753
PIK3CA	1703	-1445
PIK3CD	2422	2189
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R3	-4692	-22
PIK3R4	-1215	-3425
PILRB	-4277	19
PIM1	3377	-5227
PIN1	-955	-1656
PITPNA	2860	-2752
PJA2	3244	662
PKM	4362	-3076
PLA2G6	-4758	-3132
PLAC8	3838	-4418
PLAU	1828	-6512
PLAUR	3822	-6237
PLCG1	-4158	-3541
PLCG2	1884	-2562
PLD1	4321	-6058
PLD3	3177	1541
PLEKHO2	3605	-3111
PML	-2938	549
PNP	3818	-4436
POLR1C	-4039	-2688
POLR1D	2715	-2500
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2H	-882	1944
POLR2K	-537	-2424
POLR3A	-2354	2213
POLR3C	-2396	509
POLR3D	-4557	1264
POLR3E	-4318	-673
POLR3F	-1579	-5523
POLR3G	-1645	1201
POLR3GL	-2424	-6348
POLR3H	-3719	-510
POLR3K	-737	1383
POM121	-2766	-1787
POM121C	-2305	-4315
POU2F1	470	733
PPIA	-2133	490
PPIE	-3082	644
PPM1B	2218	1592
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5A	2347	381
PPP2R5B	2831	-6343
PPP2R5C	-4242	2376
PPP2R5D	771	-4349
PPP2R5E	-217	-2288
PPP3CA	2522	-2165
PPP3CB	2968	517
PPP3R1	3675	-3276
PRCP	3695	368
PRDX6	4109	916
PRKACA	4378	-6032
PRKACB	-4656	455
PRKCB	3029	-4518
PRKCD	4154	584
PRKCE	-2638	-5632
PRKCQ	-4762	1372
PRKCSH	1991	-3007
PRKDC	-3668	1316
PRR5	-4676	-1591
PRTN3	2825	-6448
PSAP	3061	-4192
PSEN1	3540	-3407
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PSTPIP1	3462	1135
PTEN	3844	-1100
PTGES2	-2198	-1462
PTK2	1629	920
PTK2B	3527	40
PTPN1	2254	2074
PTPN11	2038	-2302
PTPN12	3660	-1077
PTPN13	-3534	-6489
PTPN18	2482	693
PTPN2	3316	-3701
PTPN22	-379	-1114
PTPN23	-372	-3227
PTPN4	-4818	-3156
PTPN6	2452	-4586
PTPN7	-4023	-1888
PTPN9	2799	-1265
PTPRC	706	-1407
PTPRJ	3428	2365
PTPRN2	1970	2235
PYCARD	3942	-6598
PYGB	152	-5617
QPCT	4331	-6405
QSOX1	4315	-1087
RAB10	4103	-3437
RAB14	3027	1334
RAB18	3438	-1995
RAB24	2063	-3725
RAB27A	3811	-1181
RAB37	-4565	-5384
RAB3A	3646	-1080
RAB3D	4263	-6515
RAB4B	1028	1318
RAB5B	2790	-2055
RAB5C	3953	-1152
RAB6A	3657	-311
RAB7A	4002	-5570
RAC1	4031	971
RAC2	1962	-868
RACGAP1	916	1472
RAE1	1963	-39
RAF1	3488	-314
RALA	864	-262
RANBP2	-273	-4704
RAP1A	3148	323
RAP1B	1058	-1031
RAP2B	-248	-2291
RAPGEF1	-3458	1868
RASGRP1	-4668	2119
RASGRP2	-2873	1508
RASGRP3	-3259	-2004
RBBP6	-354	-2825
RBCK1	694	-1357
RBSN	-1363	-2813
RBX1	1368	-3241
RCHY1	2606	2124
REL	1202	-3846
RELA	-542	2085
RELB	1285	-5206
RHOA	3753	1313
RHOF	-4879	1911
RHOG	3858	860
RICTOR	-3383	1651
RILP	3789	-4831
RIPK3	1497	-370
RNASEL	3436	326
RNASET2	2360	2094
RNF111	2267	779
RNF114	969	-3694
RNF115	-3433	1631
RNF123	2846	2363
RNF125	-4197	-1762
RNF126	-3842	1899
RNF135	3897	-6458
RNF138	1584	1102
RNF14	1575	-1169
RNF144B	3778	-5953
RNF19A	-3658	1813
RNF19B	2827	380
RNF213	-4630	2228
RNF216	-3839	201
RNF220	-1962	1733
RNF25	-2343	-1189
RNF34	-1902	42
RNF4	-4370	-151
RNF41	3797	109
RNF6	1372	-2084
RNF7	3510	-1943
ROCK1	3246	-985
RORA	-4672	2287
RPLP0	-320	-185
RPS27A	-2201	-2138
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA5	-4445	-514
S100A11	4118	-1013
S100P	3758	1295
S1PR1	-3180	2436
SAMHD1	2619	-2016
SAR1B	2676	489
SARM1	-4766	-5412
SCAMP1	584	-356
SDCBP	4324	-2535
SEC13	2266	-3749
SEC23A	3162	-5141
SEC24A	3350	61
SEC24B	1233	-5505
SEC24C	-768	805
SEC24D	3637	-3966
SEC31A	346	-4985
SEC61A1	2654	-592
SEC61A2	-3985	917
SEC61B	2971	33
SEC61G	1745	1052
SEH1L	-1875	-1615
SERPINB1	4382	-4489
SERPINB6	2324	-5578
SH2B1	-2928	-1068
SH2B3	1358	1699
SHC1	1472	-2954
SIAH1	-897	-6217
SIAH2	3910	2185
SIGIRR	-3958	290
SIKE1	-2255	-1187
SIPA1	1408	-2006
SKP1	1536	-2290
SKP2	-2759	-1566
SLA	3335	2206
SLA2	-3338	960
SLAMF6	-4801	2420
SLC11A1	4243	-4413
SLC15A4	1288	-5940
SLC27A2	-1137	-6055
SLC2A3	4160	-4757
SLC44A2	861	2003
SLCO4C1	1061	-1063
SMAD3	-4538	-4628
SMARCA4	1758	2317
SMURF1	-780	1321
SMURF2	-3735	-3048
SNAP23	3937	-6016
SNAP29	2615	-4157
SNRPA1	-3561	-3336
SOCS1	1375	-2999
SOCS2	-757	378
SOCS3	4399	2178
SOCS5	1047	-4583
SOD1	-1475	-1019
SOD2	1587	573
SOS1	-1748	-6775
SOS2	3740	-4105
SP100	1552	-769
SPSB1	756	-3865
SPTAN1	-4344	-1250
SQSTM1	1438	-952
SRC	-2999	-4427
SRP14	2573	-848
STAT1	-4529	2195
STAT2	-3894	-3295
STAT3	3628	-3606
STAT4	-4875	-425
STAT5A	2943	-6427
STAT5B	2923	-3446
STAT6	2340	-3911
STBD1	2159	-6441
STIM1	1369	2500
STK10	-1159	-3955
STK11IP	1224	-3840
STOM	2795	-3877
STUB1	-330	-2168
STX1A	-1213	-2461
STX3	3861	-1755
STX4	189	-6001
STXBP2	4170	-6352
SUGT1	475	594
SUMO1	2903	-3986
SURF4	3001	1222
SVIP	642	-4596
SYK	4192	-5054
TAB2	2942	1892
TALDO1	4392	-5245
TANK	3251	-1331
TAP1	-3978	-4218
TAP2	-4576	1506
TAPBP	975	-1360
TAX1BP1	2418	-4470
TBC1D10C	-4609	2261
TBK1	1067	-4616
TCIRG1	3087	-5082
TCP1	1254	2168
TEC	3276	-5839
TGFB1	1959	-6
THEM4	-4130	-6129
THOP1	-3278	-3580
TICAM1	2569	-2136
TIFA	1905	-1726
TIRAP	2210	-5182
TLR1	4106	-6127
TLR2	4206	-6586
TLR3	-4406	-5820
TLR5	4260	1823
TLR6	4058	-802
TLR9	-1850	2292
TMBIM1	3776	-1433
TMC6	-3874	2299
TMEM179B	140	276
TMEM30A	3589	-1977
TMEM63A	-3139	-5444
TNF	-2348	-3779
TNFAIP3	-4067	-785
TNFRSF12A	2924	-994
TNFRSF1A	4299	-4958
TNFRSF1B	2421	2416
TNFRSF25	-3862	2275
TNFSF13	3783	-5904
TNFSF13B	3109	-6033
TNFSF14	783	2460
TNFSF9	-1885	1627
TNIP2	2166	-5726
TOLLIP	3905	-5037
TOM1	4259	-5118
TP53	-4034	-739
TPP2	-3068	-1752
TPR	-2242	-973
TRAF2	-4539	-1442
TRAF3	-1701	2379
TRAF6	-80	-6118
TRAF7	3928	-4769
TRAIP	-4458	-3435
TRAPPC1	3441	-3029
TREML2	2657	-6721
TREX1	-377	-5868
TRIB3	-1802	1669
TRIM11	-1094	586
TRIM14	-2114	-1735
TRIM2	-1371	-4681
TRIM21	775	-6370
TRIM22	-4013	-2766
TRIM25	3700	-3718
TRIM26	-3115	-2905
TRIM35	-3395	-31
TRIM36	-2087	-5030
TRIM37	-2860	-3006
TRIM38	785	-931
TRIM39	-3789	-3317
TRIM4	659	1988
TRIM41	773	-1538
TRIM45	-2497	-5568
TRIM46	-2614	-1262
TRIM5	-2217	-3945
TRIM56	-2958	141
TRIM62	-3907	-6401
TRIM68	-4679	1800
TRIM8	3807	1000
TRIM9	535	-726
TRIP12	2921	-3017
TRPC1	-3412	-2704
TRPM2	4205	-6600
TSPAN14	2946	1366
TUBB	-2209	1395
TUBB4B	3111	1856
TXK	-4496	170
TXLNA	-556	-78
TXN	3732	284
TXNDC5	122	-5179
TXNIP	-3347	-2777
TYK2	3021	-3105
TYROBP	3270	-6720
UBA3	3420	-2122
UBA5	-2767	-4241
UBA52	349	752
UBA6	1163	1251
UBA7	-2452	-6667
UBAC1	3770	-4908
UBB	2759	-1321
UBC	1618	-2568
UBE2B	2966	-2486
UBE2C	1933	1091
UBE2D1	4255	-1581
UBE2D2	1717	-3799
UBE2D3	3944	-373
UBE2D4	-4207	-3494
UBE2E1	2822	-5882
UBE2E2	551	-6256
UBE2E3	1883	-5759
UBE2F	3165	-3774
UBE2G1	1840	-1626
UBE2G2	-2650	-3560
UBE2H	3352	-1867
UBE2J1	4244	-591
UBE2J2	3722	-368
UBE2K	2901	1379
UBE2L3	3281	-3496
UBE2L6	-4256	-4206
UBE2M	3239	-3585
UBE2N	607	1127
UBE2O	668	-5963
UBE2Q1	2284	-1272
UBE2Q2	-4419	-4146
UBE2R2	3894	-3277
UBE2S	1766	2449
UBE2V1	2209	-1021
UBE2V2	934	-3487
UBE2W	3522	-618
UBE2Z	-4046	-4538
UBE3A	959	1814
UBE3B	594	-244
UBE3C	2557	223
UBE3D	-3973	-5685
UBOX5	-347	1764
UBR1	-1432	-415
UBR2	1443	-2614
UFL1	-2092	122
UNC13D	3311	-6493
UNC93B1	1479	-4358
UNKL	-696	-4290
USP18	-4814	-2616
VAMP2	-4559	-2770
VAMP3	3698	1210
VAMP8	1989	-6050
VAPA	4169	-5592
VASP	3582	-2892
VAT1	4302	-3481
VAV1	3499	-3184
VAV2	-1214	-643
VAV3	1824	-6342
VCL	3157	-5870
VCP	2902	-2411
VEGFA	3235	-2723
VHL	1262	1389
VIM	4364	-2247
VRK3	396	-1398
VTN	-613	2265
WASF1	4414	-1056
WASF2	3782	-2654
WASL	87	-4742
WIPF1	177	-4382
WIPF2	2249	-2523
WSB1	3475	-637
WWP1	-3604	-1865
XAF1	-4727	-2525
XRCC5	2075	-3770
XRCC6	-1335	376
YES1	-4772	-4415
YPEL5	2788	-1479
YWHAB	2611	2125
YWHAZ	2200	541
ZAP70	-4650	2499
ZBP1	-4869	-410
ZBTB16	215	2289
ZEB1	-2414	-1406
ZNRF1	3362	-5381
ZNRF2	198	1850

---

---

Vesicle-mediated transport

Vesicle-mediated transport

metric	value
setSize	442
pMANOVA	1.93e-20
p.adjustMANOVA	5.17e-18
s.dist	0.267
s.RNA	0.267
s.meth	3.47e-05
p.RNA	2.19e-21
p.meth	0.999

Top 20 genes

Gene	RNA	meth
CLTC	4149	2477
KDELR1	4226	1780
AP3S1	3484	2039
TMED7	3534	1939
TRAPPC8	2812	2300
AGFG1	4264	1439
MYH9	2789	2182
PPP6C	2859	2020
YWHAB	2611	2125
STX6	3507	1575
CBL	3241	1456
GOLGA2	2513	1847
VAMP3	3698	1210
VPS25	3332	1235
RAB14	3027	1334
COPA	3780	1056
RAC1	4031	971
SYNJ1	2565	1501
PAFAH1B1	2124	1763
SURF4	3001	1222

Click HERE to show all gene set members

All member genes

	RNA	meth
AAK1	-3166	-2582
ACBD3	2301	-912
ACTR10	3309	-1291
ACTR1A	2965	-1
ACTR2	3481	-3374
ACTR3	3448	-2917
ADRB2	-4624	-3531
AGFG1	4264	1439
AGPAT3	1787	-2039
AKT1	1234	-1942
AKT2	133	-141
ALS2CL	-2774	-5896
ANK1	4018	-4221
ANK3	-1491	-6563
ANKRD27	53	597
ANKRD28	-1940	-5108
AP1B1	3995	-463
AP1G1	1397	516
AP1G2	-1706	-5312
AP1M1	2798	-2408
AP1S3	-1681	-5455
AP2A1	2869	-4887
AP2M1	3936	20
AP2S1	3581	-3262
AP3B1	3779	-3148
AP3S1	3484	2039
AP4B1	-2328	-4089
AP4E1	2633	-5749
AP4M1	38	2409
AP4S1	-1756	-2809
APP	4249	-5300
ARCN1	2180	-1676
ARF1	4184	-6686
ARF3	3396	-1912
ARF4	4256	-3280
ARF5	3493	-4789
ARF6	422	-3567
ARFGAP1	-582	1688
ARFGAP3	1282	-5386
ARFIP2	-957	2033
ARFRP1	-2455	-501
ARL1	-1540	-4570
ARPC2	3191	-3647
ARPC3	3729	-3767
ARPC5	3968	-3837
ARRB1	632	-6363
ARRB2	3860	-2243
ASPSCR1	-1568	1072
BET1	-192	-4482
BET1L	-2389	332
BICD1	-2368	-5311
BICD2	4004	-4361
BIN1	-4334	2405
BLOC1S1	3938	-5160
BLOC1S3	-2942	-59
BLOC1S6	2856	-2929
BNIP1	-2466	-1561
C2CD5	-2458	-3136
CALM1	-626	-5019
CALR	2586	-3753
CAPZA1	3648	572
CAPZA2	3920	-36
CAPZB	3576	-4065
CBL	3241	1456
CCZ1	1510	2069
CD3D	-4327	2493
CD4	-1648	-6372
CD55	4229	-3923
CD59	2326	-6024
CENPE	98	-4165
CHMP2A	4024	-297
CHMP2B	2250	-4000
CHMP3	3769	-2694
CHMP4A	763	458
CHMP4B	4075	-4297
CHMP5	1850	-2010
CHMP6	2138	-2539
CHMP7	-2991	-1608
CLINT1	1325	-6738
CLTA	3788	-5077
CLTB	2446	-3627
CLTC	4149	2477
CLTCL1	4130	-4995
CNIH1	3425	-6699
COG1	-4760	-3663
COG2	-2597	-6132
COG3	-1652	-5701
COG4	-3	-984
COG5	-970	-1864
COG6	-1787	-358
COG7	1526	-4196
COG8	-118	1846
COPA	3780	1056
COPB1	3154	-1329
COPB2	3503	-1501
COPE	2906	213
COPS2	2476	896
COPS3	2403	-2950
COPS4	549	-3507
COPS5	1573	-1617
COPS6	508	-866
COPS7A	2731	-565
COPS7B	-3432	538
COPS8	-2966	-4126
COPZ1	1422	-5051
COPZ2	-4019	1305
CPD	4050	-6376
CSNK1D	760	-1777
CTSC	739	1561
CTSZ	4137	-6765
CUX1	4142	-2129
CYTH1	-4862	-1796
CYTH2	137	-4454
CYTH3	-2720	-1946
CYTH4	2447	-966
DCTN2	4235	-6011
DCTN3	2396	-4272
DCTN4	3796	-2073
DCTN5	-1222	-5100
DCTN6	3145	819
DENND1A	3223	-1692
DENND1B	-3210	2496
DENND1C	-2374	-987
DENND2C	2348	-5517
DENND2D	-4850	2236
DENND3	3530	-5361
DENND4A	-1686	-3677
DENND4B	1029	-5604
DENND5A	3400	-2375
DENND6A	-182	-223
DNM1	1225	-5619
DNM2	2448	738
DTNBP1	320	-1025
DVL2	-4172	-1356
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNLL1	2378	-3319
DYNLL2	-1189	214
EPN1	3595	-2171
EPN2	-1225	-748
EPS15	1457	-654
EPS15L1	1251	-3901
EXOC1	2225	-2298
EXOC2	-2533	1713
EXOC3	1752	-3415
EXOC4	2187	-3655
EXOC5	1459	1408
EXOC6	4012	-5526
EXOC7	1842	-4686
EXOC8	-1	2121
FCHO1	-714	-444
FCHO2	3442	-2751
FNBP1	-106	934
FTH1	1827	-521
FTL	3957	-4621
GABARAP	3505	-3859
GABARAPL2	4172	-3733
GAK	822	-380
GALNT2	4061	-5164
GAPVD1	2843	-3999
GBF1	-1279	-120
GCC1	872	-5585
GCC2	-2511	-3284
GDI2	3138	-587
GGA1	731	-3812
GGA2	-2051	-3081
GGA3	1326	450
GJD3	3563	-708
GNS	4348	-571
GOLGA1	769	-3121
GOLGA2	2513	1847
GOLGA4	-1217	-155
GOLGA5	2043	-4117
GOLGB1	-1635	-3196
GOLIM4	2021	-5765
GORASP1	2742	-2178
GOSR1	-61	-3152
GOSR2	-454	1643
GPS1	-1352	-6247
GRB2	4320	-2295
HBEGF	1889	-6428
HGS	1647	2123
HIP1	3716	107
HIP1R	-3880	-3324
HPS1	2193	-2664
HPS4	-4423	-1809
HSP90AA1	411	-781
HSP90B1	647	-1371
HSPH1	-3256	993
HYOU1	-35	-3315
IGF2R	3062	-5512
ITSN1	4309	-1048
ITSN2	1912	1310
KDELR1	4226	1780
KDELR2	3393	-2980
KIAA0319	1040	-1089
KIF11	250	-4751
KIF13B	2398	-3303
KIF15	-968	-563
KIF16B	894	-6359
KIF18A	-823	-2125
KIF18B	-44	-3342
KIF1B	3681	-4142
KIF20A	1931	-231
KIF20B	-2551	-649
KIF21A	-4595	-1704
KIF21B	-2101	1128
KIF22	-4887	-1801
KIF23	2143	-3340
KIF26B	-4487	-6613
KIF27	812	-1527
KIF2A	-340	1788
KIF2C	229	-1625
KIF3A	-4667	-2118
KIF3B	1292	-2584
KIF3C	3745	-5135
KIF5B	3711	-3520
KIF6	360	-5646
KIF9	1519	-2489
KIFAP3	-2906	1836
KIFC1	-85	901
KIFC2	-499	-5893
KLC1	2149	-1283
KLC2	-3106	-5681
KLC4	-2808	-4132
LDLR	2505	-494
LDLRAP1	-3226	643
LMAN1	-3888	596
LMAN2	3016	-2497
LMAN2L	2928	-1590
LNPEP	-3357	-478
M6PR	-2871	246
MADD	-4628	-6381
MAN1A1	3520	-447
MAN1A2	-619	-1465
MAN1C1	-2148	-1205
MAN2A1	-418	-4486
MAN2A2	2751	-5172
MCFD2	3031	-158
MIA3	-1938	-3428
MON1A	-875	-4568
MON1B	2746	-2596
MVB12A	3199	272
MYH9	2789	2182
MYO6	-4333	-3265
NAA30	-3394	-2261
NAA35	-4405	-570
NAA38	3218	-540
NAPA	438	-4125
NAPB	-838	471
NAPG	1458	-97
NBAS	58	-3794
NECAP1	697	703
NECAP2	1135	-3453
NEDD8	2677	-1600
OPTN	-4549	-5087
PACSIN1	-4894	-5957
PACSIN2	3641	-4162
PAFAH1B1	2124	1763
PAFAH1B2	2931	-1392
PAFAH1B3	1605	-434
PICALM	4161	-6069
PIP5K1C	1151	-5383
PLA2G6	-4758	-3132
PLIN3	4385	-3203
POLG	-3492	728
PPP6C	2859	2020
PPP6R1	2015	-1276
PPP6R3	1081	-3726
PRKAB1	401	-3297
PRKAB2	-2709	-1428
PRKAG1	2126	-5980
PRKAG2	636	-5033
PUM1	1076	2120
RAB10	4103	-3437
RAB11A	3969	-2965
RAB11B	1596	-387
RAB12	-284	-1635
RAB14	3027	1334
RAB18	3438	-1995
RAB1A	4176	-1703
RAB1B	3749	-264
RAB27A	3811	-1181
RAB30	-3466	-2803
RAB33B	3130	547
RAB35	1394	780
RAB3A	3646	-1080
RAB3GAP1	2277	-189
RAB3GAP2	1612	-3103
RAB3IP	1071	483
RAB43	2645	1154
RAB4A	3532	-5479
RAB5A	3035	-1686
RAB5B	2790	-2055
RAB5C	3953	-1152
RAB6A	3657	-311
RAB7A	4002	-5570
RAB8A	1346	-1289
RAB8B	2696	79
RABEP1	-4542	-119
RABEPK	1615	-3599
RABGAP1	645	1231
RABGEF1	3234	-5431
RAC1	4031	971
RACGAP1	916	1472
RALA	864	-262
RALGAPA2	4037	-5734
RALGAPB	-1237	-1988
REPS1	-2284	1890
RGP1	1657	-1273
RHOBTB3	-4186	-6232
RHOQ	3255	-1953
RIC1	2863	-4947
RIN1	3306	-1629
RINL	-3729	1118
RINT1	-3609	1777
RPS27A	-2201	-2138
SAR1B	2676	489
SBF1	-3835	882
SCARB1	2382	-4202
SCARB2	2011	-5779
SCOC	-292	-4230
SEC13	2266	-3749
SEC16A	1697	-1722
SEC22A	-1537	696
SEC22C	-1264	1879
SEC23A	3162	-5141
SEC23IP	-154	-38
SEC24A	3350	61
SEC24B	1233	-5505
SEC24C	-768	805
SEC24D	3637	-3966
SEC31A	346	-4985
SFN	500	-5994
SH3GL1	3324	1075
SNAP23	3937	-6016
SNAP29	2615	-4157
SNAPIN	3224	-4279
SNF8	2387	-2157
SNX18	2974	-1832
SNX2	3474	-4403
SPTAN1	-4344	-1250
SPTBN1	-2529	-3924
SPTBN5	-1052	2344
SRC	-2999	-4427
STAM	397	770
STAM2	2488	-2181
STX10	4099	-1571
STX16	1283	-15
STX17	-4100	-4247
STX18	1713	-16
STX4	189	-6001
STX5	3071	-1823
STX6	3507	1575
STXBP3	3212	-1306
SURF4	3001	1222
SYNJ1	2565	1501
SYNJ2	-2867	-6043
SYS1	120	-3479
SYT11	-2131	-3074
SYTL1	-3602	-5731
TBC1D1	2985	-6278
TBC1D10A	-4697	-5496
TBC1D10B	3617	-2223
TBC1D10C	-4609	2261
TBC1D13	1314	-4987
TBC1D14	4086	-5797
TBC1D15	1258	-2913
TBC1D17	-2947	1402
TBC1D2	4317	-3011
TBC1D20	-8	-5205
TBC1D24	1055	-3543
TBC1D4	-3959	-1780
TBC1D7	2656	-2436
TFRC	468	-273
TGFA	4083	-3020
TGOLN2	3988	-2836
TMED10	94	604
TMED2	2424	-3656
TMED3	868	-2936
TMED7	3534	1939
TMED9	3072	-1992
TMEM115	2141	-703
TMF1	809	277
TOR1A	3587	-4691
TOR1B	-642	1023
TPD52	-3370	-32
TRAPPC1	3441	-3029
TRAPPC10	-3243	2388
TRAPPC12	2570	1388
TRAPPC13	-740	2360
TRAPPC2L	-686	1441
TRAPPC3	3041	-2853
TRAPPC4	-2106	-3231
TRAPPC5	1974	-5629
TRAPPC6A	-4050	1765
TRAPPC6B	1463	-662
TRAPPC8	2812	2300
TRAPPC9	2048	-4354
TRIP11	-187	1568
TSC1	-638	1527
TSC2	-262	895
TSG101	3430	-5032
TXNDC5	122	-5179
UBA52	349	752
UBAP1	3980	-2481
UBB	2759	-1321
UBC	1618	-2568
UBQLN1	1938	-5425
ULK1	3049	-4553
USE1	301	-4077
USO1	1467	1196
USP6NL	1614	-2335
VAMP2	-4559	-2770
VAMP3	3698	1210
VAMP4	1049	193
VAMP8	1989	-6050
VPS25	3332	1235
VPS28	1488	-2471
VPS36	-2165	-2008
VPS37A	2668	-3512
VPS37B	1356	-6110
VPS37C	3572	421
VPS45	800	-3464
VPS4A	248	118
VPS51	-2049	-1460
VPS52	-1079	-1717
VPS53	-115	-3026
VPS54	3288	-4194
VTA1	2506	-3898
VTI1A	2032	-3252
WASL	87	-4742
YKT6	1980	-3331
YWHAB	2611	2125
YWHAE	4173	-4168
YWHAG	4294	-5545
YWHAH	3949	-2902
YWHAQ	-2362	-2908
YWHAZ	2200	541
ZW10	8	160

---

---

Membrane Trafficking

Membrane Trafficking

metric	value
setSize	436
pMANOVA	2.23e-20
p.adjustMANOVA	5.17e-18
s.dist	0.268
s.RNA	0.268
s.meth	-0.000137
p.RNA	2.52e-21
p.meth	0.996

Top 20 genes

Gene	RNA	meth
CTSZ	4137	-6765
ARF1	4184	-6686
CPD	4050	-6376
DCTN2	4235	-6011
PICALM	4161	-6069
YWHAG	4294	-5545
TBC1D14	4086	-5797
SNAP23	3937	-6016
RALGAPA2	4037	-5734
CNIH1	3425	-6699
APP	4249	-5300
RAB7A	4002	-5570
EXOC6	4012	-5526
GALNT2	4061	-5164
CLTCL1	4130	-4995
BLOC1S1	3938	-5160
RAB4A	3532	-5479
CLTA	3788	-5077
KIF3C	3745	-5135
DENND3	3530	-5361

Click HERE to show all gene set members

All member genes

	RNA	meth
AAK1	-3166	-2582
ACBD3	2301	-912
ACTR10	3309	-1291
ACTR1A	2965	-1
ACTR2	3481	-3374
ACTR3	3448	-2917
ADRB2	-4624	-3531
AGFG1	4264	1439
AGPAT3	1787	-2039
AKT1	1234	-1942
AKT2	133	-141
ALS2CL	-2774	-5896
ANK1	4018	-4221
ANK3	-1491	-6563
ANKRD27	53	597
ANKRD28	-1940	-5108
AP1B1	3995	-463
AP1G1	1397	516
AP1G2	-1706	-5312
AP1M1	2798	-2408
AP1S3	-1681	-5455
AP2A1	2869	-4887
AP2M1	3936	20
AP2S1	3581	-3262
AP3B1	3779	-3148
AP3S1	3484	2039
AP4B1	-2328	-4089
AP4E1	2633	-5749
AP4M1	38	2409
AP4S1	-1756	-2809
APP	4249	-5300
ARCN1	2180	-1676
ARF1	4184	-6686
ARF3	3396	-1912
ARF4	4256	-3280
ARF5	3493	-4789
ARF6	422	-3567
ARFGAP1	-582	1688
ARFGAP3	1282	-5386
ARFIP2	-957	2033
ARFRP1	-2455	-501
ARL1	-1540	-4570
ARPC2	3191	-3647
ARPC3	3729	-3767
ARPC5	3968	-3837
ARRB1	632	-6363
ARRB2	3860	-2243
ASPSCR1	-1568	1072
BET1	-192	-4482
BET1L	-2389	332
BICD1	-2368	-5311
BICD2	4004	-4361
BIN1	-4334	2405
BLOC1S1	3938	-5160
BLOC1S3	-2942	-59
BLOC1S6	2856	-2929
BNIP1	-2466	-1561
C2CD5	-2458	-3136
CALM1	-626	-5019
CAPZA1	3648	572
CAPZA2	3920	-36
CAPZB	3576	-4065
CBL	3241	1456
CCZ1	1510	2069
CD3D	-4327	2493
CD4	-1648	-6372
CD55	4229	-3923
CD59	2326	-6024
CENPE	98	-4165
CHMP2A	4024	-297
CHMP2B	2250	-4000
CHMP3	3769	-2694
CHMP4A	763	458
CHMP4B	4075	-4297
CHMP5	1850	-2010
CHMP6	2138	-2539
CHMP7	-2991	-1608
CLINT1	1325	-6738
CLTA	3788	-5077
CLTB	2446	-3627
CLTC	4149	2477
CLTCL1	4130	-4995
CNIH1	3425	-6699
COG1	-4760	-3663
COG2	-2597	-6132
COG3	-1652	-5701
COG4	-3	-984
COG5	-970	-1864
COG6	-1787	-358
COG7	1526	-4196
COG8	-118	1846
COPA	3780	1056
COPB1	3154	-1329
COPB2	3503	-1501
COPE	2906	213
COPS2	2476	896
COPS3	2403	-2950
COPS4	549	-3507
COPS5	1573	-1617
COPS6	508	-866
COPS7A	2731	-565
COPS7B	-3432	538
COPS8	-2966	-4126
COPZ1	1422	-5051
COPZ2	-4019	1305
CPD	4050	-6376
CSNK1D	760	-1777
CTSC	739	1561
CTSZ	4137	-6765
CUX1	4142	-2129
CYTH1	-4862	-1796
CYTH2	137	-4454
CYTH3	-2720	-1946
CYTH4	2447	-966
DCTN2	4235	-6011
DCTN3	2396	-4272
DCTN4	3796	-2073
DCTN5	-1222	-5100
DCTN6	3145	819
DENND1A	3223	-1692
DENND1B	-3210	2496
DENND1C	-2374	-987
DENND2C	2348	-5517
DENND2D	-4850	2236
DENND3	3530	-5361
DENND4A	-1686	-3677
DENND4B	1029	-5604
DENND5A	3400	-2375
DENND6A	-182	-223
DNM1	1225	-5619
DNM2	2448	738
DTNBP1	320	-1025
DVL2	-4172	-1356
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNLL1	2378	-3319
DYNLL2	-1189	214
EPN1	3595	-2171
EPN2	-1225	-748
EPS15	1457	-654
EPS15L1	1251	-3901
EXOC1	2225	-2298
EXOC2	-2533	1713
EXOC3	1752	-3415
EXOC4	2187	-3655
EXOC5	1459	1408
EXOC6	4012	-5526
EXOC7	1842	-4686
EXOC8	-1	2121
FCHO1	-714	-444
FCHO2	3442	-2751
FNBP1	-106	934
FTH1	1827	-521
FTL	3957	-4621
GABARAP	3505	-3859
GABARAPL2	4172	-3733
GAK	822	-380
GALNT2	4061	-5164
GAPVD1	2843	-3999
GBF1	-1279	-120
GCC1	872	-5585
GCC2	-2511	-3284
GDI2	3138	-587
GGA1	731	-3812
GGA2	-2051	-3081
GGA3	1326	450
GJD3	3563	-708
GNS	4348	-571
GOLGA1	769	-3121
GOLGA2	2513	1847
GOLGA4	-1217	-155
GOLGA5	2043	-4117
GOLGB1	-1635	-3196
GOLIM4	2021	-5765
GORASP1	2742	-2178
GOSR1	-61	-3152
GOSR2	-454	1643
GPS1	-1352	-6247
GRB2	4320	-2295
HBEGF	1889	-6428
HGS	1647	2123
HIP1	3716	107
HIP1R	-3880	-3324
HPS1	2193	-2664
HPS4	-4423	-1809
IGF2R	3062	-5512
ITSN1	4309	-1048
ITSN2	1912	1310
KDELR1	4226	1780
KDELR2	3393	-2980
KIAA0319	1040	-1089
KIF11	250	-4751
KIF13B	2398	-3303
KIF15	-968	-563
KIF16B	894	-6359
KIF18A	-823	-2125
KIF18B	-44	-3342
KIF1B	3681	-4142
KIF20A	1931	-231
KIF20B	-2551	-649
KIF21A	-4595	-1704
KIF21B	-2101	1128
KIF22	-4887	-1801
KIF23	2143	-3340
KIF26B	-4487	-6613
KIF27	812	-1527
KIF2A	-340	1788
KIF2C	229	-1625
KIF3A	-4667	-2118
KIF3B	1292	-2584
KIF3C	3745	-5135
KIF5B	3711	-3520
KIF6	360	-5646
KIF9	1519	-2489
KIFAP3	-2906	1836
KIFC1	-85	901
KIFC2	-499	-5893
KLC1	2149	-1283
KLC2	-3106	-5681
KLC4	-2808	-4132
LDLR	2505	-494
LDLRAP1	-3226	643
LMAN1	-3888	596
LMAN2	3016	-2497
LMAN2L	2928	-1590
LNPEP	-3357	-478
M6PR	-2871	246
MADD	-4628	-6381
MAN1A1	3520	-447
MAN1A2	-619	-1465
MAN1C1	-2148	-1205
MAN2A1	-418	-4486
MAN2A2	2751	-5172
MCFD2	3031	-158
MIA3	-1938	-3428
MON1A	-875	-4568
MON1B	2746	-2596
MVB12A	3199	272
MYH9	2789	2182
MYO6	-4333	-3265
NAA30	-3394	-2261
NAA35	-4405	-570
NAA38	3218	-540
NAPA	438	-4125
NAPB	-838	471
NAPG	1458	-97
NBAS	58	-3794
NECAP1	697	703
NECAP2	1135	-3453
NEDD8	2677	-1600
OPTN	-4549	-5087
PACSIN1	-4894	-5957
PACSIN2	3641	-4162
PAFAH1B1	2124	1763
PAFAH1B2	2931	-1392
PAFAH1B3	1605	-434
PICALM	4161	-6069
PIP5K1C	1151	-5383
PLA2G6	-4758	-3132
PLIN3	4385	-3203
POLG	-3492	728
PPP6C	2859	2020
PPP6R1	2015	-1276
PPP6R3	1081	-3726
PRKAB1	401	-3297
PRKAB2	-2709	-1428
PRKAG1	2126	-5980
PRKAG2	636	-5033
PUM1	1076	2120
RAB10	4103	-3437
RAB11A	3969	-2965
RAB11B	1596	-387
RAB12	-284	-1635
RAB14	3027	1334
RAB18	3438	-1995
RAB1A	4176	-1703
RAB1B	3749	-264
RAB27A	3811	-1181
RAB30	-3466	-2803
RAB33B	3130	547
RAB35	1394	780
RAB3A	3646	-1080
RAB3GAP1	2277	-189
RAB3GAP2	1612	-3103
RAB3IP	1071	483
RAB43	2645	1154
RAB4A	3532	-5479
RAB5A	3035	-1686
RAB5B	2790	-2055
RAB5C	3953	-1152
RAB6A	3657	-311
RAB7A	4002	-5570
RAB8A	1346	-1289
RAB8B	2696	79
RABEP1	-4542	-119
RABEPK	1615	-3599
RABGAP1	645	1231
RABGEF1	3234	-5431
RAC1	4031	971
RACGAP1	916	1472
RALA	864	-262
RALGAPA2	4037	-5734
RALGAPB	-1237	-1988
REPS1	-2284	1890
RGP1	1657	-1273
RHOBTB3	-4186	-6232
RHOQ	3255	-1953
RIC1	2863	-4947
RIN1	3306	-1629
RINL	-3729	1118
RINT1	-3609	1777
RPS27A	-2201	-2138
SAR1B	2676	489
SBF1	-3835	882
SCARB2	2011	-5779
SCOC	-292	-4230
SEC13	2266	-3749
SEC16A	1697	-1722
SEC22A	-1537	696
SEC22C	-1264	1879
SEC23A	3162	-5141
SEC23IP	-154	-38
SEC24A	3350	61
SEC24B	1233	-5505
SEC24C	-768	805
SEC24D	3637	-3966
SEC31A	346	-4985
SFN	500	-5994
SH3GL1	3324	1075
SNAP23	3937	-6016
SNAP29	2615	-4157
SNAPIN	3224	-4279
SNF8	2387	-2157
SNX18	2974	-1832
SNX2	3474	-4403
SPTAN1	-4344	-1250
SPTBN1	-2529	-3924
SPTBN5	-1052	2344
SRC	-2999	-4427
STAM	397	770
STAM2	2488	-2181
STX10	4099	-1571
STX16	1283	-15
STX17	-4100	-4247
STX18	1713	-16
STX4	189	-6001
STX5	3071	-1823
STX6	3507	1575
STXBP3	3212	-1306
SURF4	3001	1222
SYNJ1	2565	1501
SYNJ2	-2867	-6043
SYS1	120	-3479
SYT11	-2131	-3074
SYTL1	-3602	-5731
TBC1D1	2985	-6278
TBC1D10A	-4697	-5496
TBC1D10B	3617	-2223
TBC1D10C	-4609	2261
TBC1D13	1314	-4987
TBC1D14	4086	-5797
TBC1D15	1258	-2913
TBC1D17	-2947	1402
TBC1D2	4317	-3011
TBC1D20	-8	-5205
TBC1D24	1055	-3543
TBC1D4	-3959	-1780
TBC1D7	2656	-2436
TFRC	468	-273
TGFA	4083	-3020
TGOLN2	3988	-2836
TMED10	94	604
TMED2	2424	-3656
TMED3	868	-2936
TMED7	3534	1939
TMED9	3072	-1992
TMEM115	2141	-703
TMF1	809	277
TOR1A	3587	-4691
TOR1B	-642	1023
TPD52	-3370	-32
TRAPPC1	3441	-3029
TRAPPC10	-3243	2388
TRAPPC12	2570	1388
TRAPPC13	-740	2360
TRAPPC2L	-686	1441
TRAPPC3	3041	-2853
TRAPPC4	-2106	-3231
TRAPPC5	1974	-5629
TRAPPC6A	-4050	1765
TRAPPC6B	1463	-662
TRAPPC8	2812	2300
TRAPPC9	2048	-4354
TRIP11	-187	1568
TSC1	-638	1527
TSC2	-262	895
TSG101	3430	-5032
TXNDC5	122	-5179
UBA52	349	752
UBAP1	3980	-2481
UBB	2759	-1321
UBC	1618	-2568
UBQLN1	1938	-5425
ULK1	3049	-4553
USE1	301	-4077
USO1	1467	1196
USP6NL	1614	-2335
VAMP2	-4559	-2770
VAMP3	3698	1210
VAMP4	1049	193
VAMP8	1989	-6050
VPS25	3332	1235
VPS28	1488	-2471
VPS36	-2165	-2008
VPS37A	2668	-3512
VPS37B	1356	-6110
VPS37C	3572	421
VPS45	800	-3464
VPS4A	248	118
VPS51	-2049	-1460
VPS52	-1079	-1717
VPS53	-115	-3026
VPS54	3288	-4194
VTA1	2506	-3898
VTI1A	2032	-3252
WASL	87	-4742
YKT6	1980	-3331
YWHAB	2611	2125
YWHAE	4173	-4168
YWHAG	4294	-5545
YWHAH	3949	-2902
YWHAQ	-2362	-2908
YWHAZ	2200	541
ZW10	8	160

---

---

Signal Transduction

Signal Transduction

metric	value
setSize	1292
pMANOVA	1.72e-18
p.adjustMANOVA	3.34e-16
s.dist	0.154
s.RNA	0.151
s.meth	0.0268
p.RNA	2.13e-18
p.meth	0.122

Top 20 genes

Gene	RNA	meth
CLTC	4149	2477
FURIN	4191	2351
ACTN1	4201	2335
SOCS3	4399	2178
NTSR1	4038	2286
PTPRJ	3428	2365
DGKG	3539	2259
ADAP1	3278	2385
GNG5	4043	1920
PHC2	4171	1830
CTSD	4381	1642
ECE1	3724	1921
RNF146	3975	1789
ACTG1	3901	1793
ATP6V1A	4318	1580
RGS14	2934	2215
ATP6V0B	3921	1604
LAMTOR2	3287	1882
MYH9	2789	2182
PPP2CB	3381	1797

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
AAMP	-1084	-5298
AATF	1611	1712
ABCA1	2459	-6487
ABCD3	1847	-2453
ABCG1	-2617	2179
ABHD12	-3773	-129
ABHD17A	-3913	902
ABHD17B	-17	-1287
ABHD6	-854	-284
ABI1	3018	-1788
ABI2	-4048	-5451
ABL1	63	-4891
ABL2	1565	301
ABR	2548	-1237
ACBD5	-398	-2520
ACTA2	-143	-3190
ACTB	4156	-4515
ACTG1	3901	1793
ACTN1	4201	2335
ACTR2	3481	-3374
ACTR3	3448	-2917
ACVR1B	4222	-6300
ACVR2A	-4287	-4829
ADAM10	4030	976
ADAM17	3634	774
ADAP1	3278	2385
ADCY4	2020	-6389
ADCY7	-980	-5596
ADCY9	33	-2618
ADD3	1290	2319
ADGRE5	-769	-5511
ADM	4359	-6151
ADORA2A	1094	-5935
ADORA3	2292	-6581
ADRB2	-4624	-3531
AGO1	2217	1997
AGO2	967	2447
AGO3	-324	-6442
AHCTF1	-500	-3122
AHCYL1	2658	-3553
AKAP13	1138	-2154
AKT1	1234	-1942
AKT1S1	3477	-2319
AKT2	133	-141
ALDH3A2	264	-2186
AMIGO2	-4070	-516
ANKFY1	-420	1915
ANKLE2	-1192	-195
ANKRD26	-836	235
ANLN	1916	-1032
AP2A1	2869	-4887
AP2M1	3936	20
AP2S1	3581	-3262
APBB1IP	4003	-5120
APC	1073	-4775
APH1A	1453	-6066
APH1B	2555	2056
APP	4249	-5300
ARAP1	3447	-1837
ARAP2	-4675	1602
ARF6	422	-3567
ARFGAP3	1282	-5386
ARHGAP1	1694	-1385
ARHGAP10	-3012	2322
ARHGAP11A	510	1998
ARHGAP11B	-2536	-695
ARHGAP12	-2448	-1220
ARHGAP15	79	-1044
ARHGAP17	-2582	-1278
ARHGAP18	4066	-4990
ARHGAP19	3414	-1466
ARHGAP21	1896	-3300
ARHGAP23	2198	2467
ARHGAP25	-2841	-6181
ARHGAP26	3781	-2076
ARHGAP27	2308	-6332
ARHGAP30	1902	1011
ARHGAP35	-1001	-3660
ARHGAP39	-2705	-5852
ARHGAP5	-3027	-1039
ARHGAP9	2545	2156
ARHGDIA	2455	2217
ARHGDIB	3943	661
ARHGEF1	-1695	1695
ARHGEF12	1041	-4362
ARHGEF17	2881	-75
ARHGEF19	-2981	-1607
ARHGEF2	2704	-4190
ARHGEF26	-1186	-6309
ARHGEF3	-4696	-1916
ARHGEF39	-4005	-4135
ARHGEF7	-1379	-5507
ARL13B	-916	762
ARL2	-183	-4526
ARL4C	-4852	1933
ARPC1B	4291	-2022
ARPC2	3191	-3647
ARPC3	3729	-3767
ARPC5	3968	-3837
ARRB1	632	-6363
ARRB2	3860	-2243
ASH2L	2400	-3791
ATF1	2245	-2565
ATN1	65	-5111
ATP2A1	-1409	-4587
ATP2A2	3591	1489
ATP2A3	-299	1190
ATP6V0A1	4375	-5877
ATP6V0A2	-4811	689
ATP6V0B	3921	1604
ATP6V0C	4218	-4697
ATP6V0D1	4282	-1003
ATP6V0E1	3919	-2865
ATP6V0E2	-4420	-6625
ATP6V1A	4318	1580
ATP6V1B2	4178	-4232
ATP6V1C1	3887	655
ATP6V1D	4174	-1234
ATP6V1E1	3588	-3948
ATP6V1F	2338	1350
ATP6V1G2	-3312	-3714
ATP6V1H	3607	-1695
AURKB	269	-889
AXIN1	-3703	-5655
AXIN2	-2699	-4719
B4GALT1	1540	-160
B9D2	3670	-881
BAD	2904	-1382
BAG4	3756	-3089
BAIAP2	-72	1977
BAMBI	3809	-6108
BAX	2357	-3623
BCL2	-1421	2361
BCL2L1	3979	1306
BCL2L11	3187	1781
BCL9	-374	-4834
BCR	-2261	-6682
BIRC2	1737	-1862
BIRC3	-4159	-2320
BIRC5	1291	-84
BMI1	-3460	-6383
BMPR1A	-2786	2273
BMPR2	1156	1438
BRAF	403	-4347
BRAP	2076	-3662
BRK1	2983	1970
BTRC	-1493	-2427
BUB1	1125	-3844
BUB1B	968	-3456
BUB3	-4515	-1487
C1QBP	-275	-2507
C3AR1	3573	-6729
CAB39	3728	-2802
CAB39L	-167	-190
CALM1	-626	-5019
CAMK2D	-4581	-2867
CAMK2G	601	2354
CAMK4	-3531	1482
CAMKK1	2572	1958
CAMKK2	3642	-6236
CAPZB	3576	-4065
CASP10	-1032	-6612
CASP3	-208	-2764
CASP8	-4285	387
CASP9	3366	-234
CAV1	619	-2432
CBFB	656	-3766
CBL	3241	1456
CBX4	699	-5288
CBX6	1421	-3511
CBX8	2112	2207
CBY1	-3586	-1167
CCDC115	-2838	2165
CCDC88A	3075	-4925
CCDC88C	-4709	2395
CCNC	589	-1138
CCND1	-2214	-6213
CCND3	3245	905
CCNE1	-4514	-3403
CCNK	923	-6142
CCNT1	-3292	1773
CCR1	4074	-6480
CCR10	-267	-1621
CCR7	-2484	2398
CCT2	-3002	-727
CCT6A	-210	1098
CCT7	-931	243
CD55	4229	-3923
CDC14A	-3615	-2150
CDC14B	519	1657
CDC20	1401	116
CDC25C	1865	-2877
CDC42	3268	-2719
CDC42EP3	4078	-1099
CDC42EP4	2101	-1671
CDC42SE2	-4241	-836
CDC73	1891	-2092
CDCA8	-553	472
CDK1	472	-4215
CDK2	-1522	1018
CDK4	-4235	-1295
CDK5	3929	-506
CDK5R1	-346	-2113
CDK8	-594	-5509
CDK9	-1171	1524
CDKN1A	1646	-3540
CDKN1B	-2723	-862
CDON	-2710	-2931
CENPA	1473	631
CENPE	98	-4165
CENPF	869	-1452
CENPH	-2913	-5334
CENPK	-2785	-1370
CENPL	-4560	-2599
CENPM	-1636	1202
CENPN	4	936
CENPO	-1561	-1800
CENPP	-4579	-3972
CENPQ	-1981	-3488
CENPT	-3351	-3323
CENPU	-2099	-3857
CEP97	-867	-4661
CFL1	3683	912
CFLAR	3312	197
CHD1	19	-1222
CHD3	-3413	422
CHD4	-1351	-4634
CHD8	188	-6248
CHEK1	-741	-211
CHN1	-2557	-4729
CHUK	3543	1343
CIT	-1541	1151
CKAP4	4355	-6717
CKAP5	-1939	-4385
CKB	-4724	-4979
CLASP1	-191	-390
CLASP2	-647	-4366
CLIP1	3888	-5910
CLIP3	-3525	-5251
CLTA	3788	-5077
CLTB	2446	-3627
CLTC	4149	2477
CNOT6L	-4229	-5686
CNR2	-2486	-6656
COL9A2	-3430	-2895
COPS2	2476	896
COPS4	549	-3507
CPD	4050	-6376
CPNE8	3671	-6070
CPT1A	1921	-6398
CREB1	-430	-672
CREBBP	1153	-5804
CRK	4091	-4581
CRKL	1387	-906
CSK	1990	862
CSNK1A1	3419	769
CSNK1E	-3709	-4750
CSNK1G2	284	-1639
CSNK2A2	2614	-4422
CSNK2B	1389	-998
CTBP1	-2010	2394
CTNNB1	2626	-1691
CTNNBIP1	3289	1401
CTNND1	-2821	1566
CTSD	4381	1642
CUL1	-4281	-5146
CUL3	2861	2054
CUL5	265	-3077
CXCL2	2093	-6755
CXCR4	-19	-1660
CXXC5	-2247	-4582
CYBA	2922	1006
CYFIP1	4295	-6630
CYFIP2	-3754	2232
CYLD	-3240	1406
DAAM1	1174	-4155
DACT1	389	-4564
DAGLB	2303	-6635
DBN1	2067	2082
DBT	-1677	-4561
DDRGK1	1446	-1249
DDX5	-3465	1288
DEF6	-2440	-2868
DEPDC1B	547	-5291
DERL2	987	-2287
DGKA	-2629	2375
DGKD	-162	546
DGKE	-4323	-953
DGKG	3539	2259
DGKH	-953	-6190
DGKQ	-2697	1446
DGKZ	-1742	-6294
DHRS3	-4733	-4924
DHRS4	1315	740
DIAPH1	-283	1033
DISP2	-2288	-4171
DLAT	-1050	-1484
DLD	3147	1320
DLG1	-2787	-3985
DLG2	-1752	1854
DLG4	4153	-3021
DLGAP5	1015	-2706
DNAJB1	-1737	-3687
DNAL4	1142	-45
DNM1	1225	-5619
DNM2	2448	738
DNMBP	-492	-6146
DOCK10	-3945	-5645
DOCK4	3371	697
DOCK7	-708	-5883
DOCK8	2415	-944
DOCK9	-3933	1757
DRAP1	-2249	-2142
DSN1	-3971	369
DST	-3867	-6289
DTX4	2486	1530
DUSP1	2935	238
DUSP10	-503	-1469
DUSP16	-2082	-2622
DUSP2	-3245	616
DUSP3	4305	-1798
DUSP4	-1957	-3176
DUSP5	-4821	1801
DUSP6	1570	-6763
DUSP7	-960	-1322
DVL1	0	-4520
DVL2	-4172	-1356
DVL3	2219	-3704
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNC2H1	-2611	-2623
DYNLL1	2378	-3319
DYNLL2	-1189	214
E2F1	2589	-1005
E2F3	2768	-2884
E2F4	2567	-172
E2F5	-2887	-2646
EBAG9	-3650	-2026
ECE1	3724	1921
ECT2	2175	-2378
EED	-3235	-1174
EEF2K	-4141	-2191
EEPD1	2544	-5914
EFCAB7	-1651	-5871
EFHD2	2279	2218
EGR1	1023	-163
EGR2	-450	-2628
EIF4B	387	-4336
EIF4E	1789	1536
EIF4EBP1	2435	150
EIF4G1	3585	746
ELMO1	2547	-2714
ELMO2	1591	1326
EP300	2471	-4509
EPAS1	3494	535
EPN1	3595	-2171
EPOR	3103	-3354
EPS15	1457	-654
EPS15L1	1251	-3901
EPSTI1	-4703	1300
ERBB2	-4865	-5145
ERLEC1	217	-2711
ESR2	-3194	-2661
ESRP2	-2936	-6611
ESYT1	-4827	959
ETV4	-1009	1547
EVL	-4808	2303
EZH2	-3415	-20
F11R	3604	-5665
FABP5	2411	-3534
FADD	2211	-6328
FAF2	2168	-4965
FAM135A	-3682	-472
FAM13A	3192	-5682
FAM13B	-3831	2059
FAM91A1	2203	-2857
FARP2	-3348	1936
FAS	1281	-5824
FASN	-223	1100
FBXW7	-2055	-5428
FER	541	-3332
FES	4278	-6334
FGD3	1147	-720
FGF9	-2970	1634
FGFBP3	-3207	1
FGFRL1	-4558	-2409
FKBP1A	4177	-4465
FKBP4	263	-4442
FKBP5	4199	-5653
FLOT1	4125	-5214
FLOT2	3815	-2231
FLT3LG	-3495	1573
FMNL1	1465	1919
FMNL3	-4736	1022
FNBP1	-106	934
FNTA	-1755	1499
FNTB	2444	-4949
FOS	2120	2149
FOSB	418	-332
FOSL1	4028	737
FOXO1	-3290	-5036
FOXO3	3966	711
FRAT1	3987	351
FRAT2	4202	1206
FRS2	-1025	-1999
FRS3	3166	-2329
FSTL3	4310	88
FURIN	4191	2351
FUZ	255	-5859
FYN	-4495	1957
FZD2	2663	-3363
FZD3	-2303	-2823
FZD5	4411	-2513
FZD6	-2030	-6235
FZD7	-2024	-3834
FZD8	-2285	-6560
GAB2	3629	-6153
GABBR1	-706	-6350
GALNT3	557	-2941
GAS8	1640	-6325
GATA3	-4799	1861
GATAD2A	999	-256
GATAD2B	-535	-2871
GFOD1	-4431	29
GGA3	1326	450
GIPR	-4745	-2380
GIT1	-3293	-6740
GIT2	3579	-2792
GLI1	965	-3214
GMIP	3471	-1646
GNA12	1128	-3386
GNA13	2310	-2285
GNA15	4391	-6690
GNAI2	3616	-1747
GNAI3	3536	-909
GNAL	-2267	855
GNAQ	4145	-6733
GNAS	3508	951
GNAT1	280	-1680
GNB1	3736	-2920
GNB2	3650	-309
GNB4	3163	-6007
GNB5	163	1821
GNG2	-2538	-3847
GNG3	285	2231
GNG4	-649	2073
GNG5	4043	1920
GNG7	-1581	-4773
GNGT2	-4735	2438
GNRHR2	-2894	25
GOLGA3	-1238	-3371
GOLGA7	1429	-2970
GOPC	-3461	-4388
GPAM	-3683	-4630
GPR132	-148	688
GPR183	-4572	-6590
GPR35	2956	-6091
GPR65	1505	2382
GPR68	-4777	273
GPS1	-1352	-6247
GPS2	-293	-857
GPSM2	1718	528
GPSM3	2917	-1982
GRAP2	1736	-5763
GRB10	4386	-70
GRB2	4320	-2295
GRIN2D	2314	-4745
GRK5	-300	1500
GRK6	2728	-613
GSK3A	3415	-2192
GSK3B	2756	736
GTF2A1	865	271
GTF2A2	3006	-1036
GTF2F1	1854	-1723
GTF2F2	2104	-2885
HBEGF	1889	-6428
HDAC1	184	-1016
HDAC10	721	-1304
HDAC11	1771	-3595
HDAC2	2129	-46
HDAC3	1727	-3771
HDAC4	4126	-3817
HDAC5	1746	-3144
HDAC7	2465	-4900
HEBP1	3705	-6287
HEY2	-3420	2330
HGS	1647	2123
HHAT	-3216	-5389
HIF1A	3219	-3349
HINT2	-2225	-1935
HMOX2	-4583	2130
HNRNPC	2536	-1112
HNRNPF	1366	-58
HNRNPH1	-2604	-1020
HNRNPM	1976	-4945
HRAS	-1008	-4780
HRH2	4395	-6490
HSP90AA1	411	-781
HSP90AB1	-2171	-5745
HSPB1	582	-4137
HSPE1	-2467	-675
ICMT	-252	-71
ID1	1843	-3980
ID2	-4082	566
ID3	-3355	1995
IER3	3232	-5549
IFT122	1701	-1191
IFT140	-1318	319
IFT172	-3949	-5159
IFT52	-489	-3194
IFT57	-546	-3279
IGF1R	2394	-4939
IKBKB	-1640	-3894
IKZF1	-2501	1828
IL1RAP	3063	-456
IL2RA	-2295	-6462
IL2RB	-4882	2472
IL32	-3617	2512
IL6R	3645	-6410
IL6ST	1415	1094
INCENP	-1832	-2850
INSR	3730	-2668
IQGAP1	3661	1271
IQGAP2	2738	-246
IRS1	533	-4060
IRS2	3903	-5410
ITCH	407	-1366
ITGA2	1478	-3856
ITGAV	2457	-5201
ITGB3BP	-2476	-3559
ITPR1	-2478	-3278
ITPR2	2315	-6107
ITPR3	-3717	-3427
ITSN1	4309	-1048
JAK1	-4072	-1022
JAK2	857	-1751
JUN	1286	69
JUNB	2850	-3031
JUND	478	-1239
KANK1	-1183	-270
KAT2A	-3970	-5050
KAT2B	-722	-1588
KAT5	405	-650
KBTBD7	2608	-1326
KCTD13	-2901	-5195
KCTD3	3821	-6134
KCTD6	1579	886
KDM1A	-3266	900
KDM1B	1918	1468
KDM3A	-4746	356
KDM4A	-9	-2080
KDM4B	3509	-6013
KDM4C	-3957	707
KHDRBS1	920	75
KIDINS220	3009	189
KIF14	1120	-4112
KIF18A	-823	-2125
KIF2A	-340	1788
KIF2C	229	-1625
KIF3A	-4667	-2118
KIF5B	3711	-3520
KLC1	2149	-1283
KLC2	-3106	-5681
KLC4	-2808	-4132
KLHL12	3215	-238
KMT2D	1057	-6199
KNTC1	-2588	-1314
KPNA2	-2190	-874
KRAS	1276	440
KSR1	1477	2466
KTN1	1126	-2404
LAMA2	-3504	-1315
LAMB2	156	-2207
LAMTOR1	4371	-5950
LAMTOR2	3287	1882
LAMTOR3	3292	321
LAMTOR4	1619	-6150
LAMTOR5	3865	-5095
LATS1	-548	71
LATS2	2470	-5622
LBR	3631	-3506
LCK	-4596	2489
LEMD3	-237	-1598
LEO1	10	791
LEPR	2679	-4010
LETM1	-1375	-460
LFNG	-2806	1932
LIMK1	1730	-3787
LIMK2	3615	-6093
LIN7B	-1111	-5689
LMAN1	-3888	596
LMNB1	4342	-942
LPAR2	2419	-1201
LPAR5	-4151	2234
LPAR6	-1062	2492
LRIG1	-3766	-3314
LRP5	1538	1949
LRP6	180	-4544
LRRC1	-4611	-2259
LRRC41	3257	404
LTB4R	4027	-6121
LTB4R2	119	-5920
LYL1	3697	-6435
LYPLA1	3652	184
MAD1L1	-1515	-3166
MAD2L1	-2608	268
MADD	-4628	-6381
MAF1	2255	-3519
MAML1	2088	-5348
MAML2	-189	-2078
MAML3	4123	-4054
MAP2K1	4183	-698
MAP2K2	2840	-3962
MAP2K5	1370	-3572
MAP3K11	3325	-2732
MAP3K7	761	-2089
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK6	3504	-2959
MAPK7	-412	-1630
MAPK8	-3265	6
MAPKAP1	1911	1057
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MAPRE1	3348	-4451
MARK3	3976	-3461
MBD3	-170	1673
MDM2	1551	-1318
MED1	-1206	-2271
MEF2A	3571	-2822
MEF2D	-929	-3018
MEMO1	4063	-3910
MEN1	-2877	-2311
MFN1	-1508	-659
MFN2	2816	-4801
MFNG	-1854	-3250
MIB1	-896	-2718
MIS12	-4042	-4678
MKNK1	3672	1538
MKRN1	4045	-2133
MKS1	-3891	-3341
MLST8	117	287
MOB1B	3094	-5948
MOV10	-4681	-6449
MSI2	-3713	-5607
MST1	270	1514
MST1R	-1712	-4446
MTA2	-2350	1649
MTA3	-3267	-1740
MTMR4	951	-1420
MTOR	-3429	-1813
MTR	-4685	448
MTX1	4134	-6117
MXD4	-4252	-2602
MYB	88	1502
MYD88	3649	-1927
MYH10	206	-4405
MYH9	2789	2182
MYL6	3908	-19
MYLIP	-1191	-681
MYO19	-3614	-2009
MYO6	-4333	-3265
MYO9A	-3343	-2971
MYO9B	2637	687
NAB1	416	-2731
NAB2	-3772	989
NBEA	-227	-6575
NCBP1	-1807	-3745
NCBP2	-3329	-4067
NCF4	4298	-6732
NCK1	-4361	-1408
NCK2	1848	-4310
NCKAP1L	3360	-6178
NCKIPSD	97	-4332
NCOA2	343	1407
NCOA3	1198	-2266
NCOR1	2341	-3738
NCOR2	3557	-4281
NCSTN	4254	-3821
NDC80	-3151	-1589
NDE1	833	1771
NDEL1	3326	1440
NDUFA5	-1429	1424
NDUFS3	283	-2069
NEDD4	2511	-5611
NEDD4L	3485	-5066
NEDD8	2677	-1600
NELFB	115	1822
NET1	-2395	-6606
NF1	985	-2145
NF2	-2034	-2754
NFATC1	-3145	2372
NFKBIA	2851	1159
NLK	1145	340
NLN	2836	1352
NMB	-366	-4459
NOS3	-620	-1770
NOTCH1	1743	1722
NOTCH4	-1593	-6455
NOXA1	-1664	-5872
NPHP4	497	-406
NR1H2	3207	-1471
NR1H3	-1069	-2305
NR3C1	162	-2420
NR4A1	-2128	657
NSL1	2090	-1214
NSMAF	-403	908
NTRK1	-2715	898
NTSR1	4038	2286
NUDC	-229	-134
NUF2	-1287	-474
NUMB	4372	-35
NUP107	-3782	-1197
NUP133	-2528	112
NUP160	-3847	763
NUP37	998	-1886
NUP43	-3314	1617
NUP85	-912	317
NUP98	1012	315
OBSCN	-2113	2406
OPN3	2371	-4940
OPRL1	3478	-6696
OS9	4087	-975
OSBPL11	4138	-3232
OTUD3	-3966	-1582
OTUD7B	-4742	-2644
OTULIN	-219	1535
P2RY1	3468	-5377
P2RY2	2384	-5187
P4HB	3831	-1549
PAFAH1B1	2124	1763
PAG1	2019	262
PAK1	3703	-3995
PAK2	3682	-3961
PAK4	-464	-1464
PAQR3	-1147	-6242
PARD6A	-83	1063
PARP1	-4548	-5521
PCSK5	1812	-4883
PDE1B	2336	-6326
PDE2A	-265	-391
PDE3B	-4275	-4025
PDE4A	-1047	820
PDE4B	-2400	-6523
PDE4C	2263	-5822
PDE4D	381	-5510
PDE5A	2786	-5047
PDE6B	-4321	-3931
PDE6D	2008	-115
PDE7A	-4029	1356
PDE7B	-554	2139
PDE8A	-2210	-5556
PDHB	1506	-3400
PDHX	1535	1616
PDK1	1516	-2149
PDK2	-2655	-941
PDPK1	2474	167
PEA15	-2156	1280
PEAK1	1161	-617
PEBP1	-4246	-152
PELP1	-4054	-1579
PFN1	2119	833
PFN2	-697	-6463
PGF	-1789	1959
PGRMC2	-1767	1519
PHB	-894	-3178
PHC1	-2820	-5180
PHC2	4171	1830
PHC3	-2698	1805
PHIP	452	-8
PHLPP1	1253	-3320
PHLPP2	-4649	-2806
PICALM	4161	-6069
PIK3AP1	3445	-4753
PIK3CA	1703	-1445
PIK3CD	2422	2189
PIK3CG	569	-2045
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R3	-4692	-22
PIK3R4	-1215	-3425
PIK3R5	-688	514
PIN1	-955	-1656
PIP4K2A	-707	1772
PIP4K2B	-2535	-6347
PIP4K2C	-4309	-5573
PIP5K1A	2460	-348
PIP5K1C	1151	-5383
PKN1	-662	-73
PKN2	27	1241
PKN3	-1123	-2518
PKP4	988	-5121
PLCB2	1721	-3046
PLCB3	4097	-5846
PLCG1	-4158	-3541
PLCG2	1884	-2562
PLD1	4321	-6058
PLEKHG2	3195	-1689
PLEKHG3	-4387	-6645
PLIN3	4385	-3203
PLK1	973	-5093
PLXND1	3238	-6504
PMEPA1	-1182	-5127
PMF1	1127	785
PML	-2938	549
POFUT1	646	973
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
POU2F1	470	733
PPARD	-1990	660
PPM1A	3687	-3764
PPP1CA	1435	550
PPP1CB	3004	1839
PPP1CC	2581	-754
PPP1R12A	2423	-629
PPP1R12B	548	-3636
PPP1R15A	2389	-5399
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5A	2347	381
PPP2R5B	2831	-6343
PPP2R5C	-4242	2376
PPP2R5D	771	-4349
PPP2R5E	-217	-2288
PPP3CA	2522	-2165
PPP3CB	2968	517
PPP3CC	-4761	1250
PPP3R1	3675	-3276
PPP5C	-2412	-41
PRC1	311	-1963
PRDM4	-3630	1199
PREX1	2628	2109
PRKAA1	409	227
PRKAB1	401	-3297
PRKAB2	-2709	-1428
PRKACA	4378	-6032
PRKACB	-4656	455
PRKAG1	2126	-5980
PRKAG2	636	-5033
PRKAR1A	3924	-201
PRKAR1B	3514	731
PRKAR2A	2493	-4298
PRKCA	356	810
PRKCB	3029	-4518
PRKCD	4154	584
PRKCE	-2638	-5632
PRKCH	-4868	1376
PRKCI	-43	-4275
PRKCQ	-4762	1372
PRKCZ	-4470	-5220
PRMT1	-3186	-740
PROK2	4039	-6705
PRR5	-4676	-1591
PSAP	3061	-4192
PSEN1	3540	-3407
PSEN2	-2508	-5155
PSENEN	2260	-3620
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTBP1	-68	-1843
PTCH1	-4643	2048
PTCH2	-1423	-127
PTEN	3844	-1100
PTGER2	448	-5853
PTGER4	-4508	1153
PTGES3	1450	-1810
PTK2	1629	920
PTK2B	3527	40
PTPN1	2254	2074
PTPN11	2038	-2302
PTPN12	3660	-1077
PTPN13	-3534	-6489
PTPN18	2482	693
PTPN2	3316	-3701
PTPN6	2452	-4586
PTPN7	-4023	-1888
PTPRA	-1393	1436
PTPRJ	3428	2365
PTPRU	-816	1974
PXN	2531	-5712
PYGO2	-4278	113
QRFP	442	-6764
RAB4A	3532	-5479
RAB4B	1028	1318
RAB6A	3657	-311
RAB7A	4002	-5570
RAC1	4031	971
RAC2	1962	-868
RAC3	-973	-5670
RACGAP1	916	1472
RAD21	527	702
RAF1	3488	-314
RALA	864	-262
RALB	3814	-1081
RALBP1	2841	-607
RALGAPA1	-4066	43
RALGDS	-4770	1254
RANBP10	816	-5295
RANBP2	-273	-4704
RANBP9	2299	-1361
RANGAP1	-4525	1644
RAP1A	3148	323
RAP1B	1058	-1031
RAP1GDS1	444	-143
RAPGEF1	-3458	1868
RARA	2642	-5249
RARG	-1567	-5402
RASA1	664	-167
RASA2	-1291	1142
RASA3	-4584	205
RASAL1	-336	-3249
RASAL3	-4691	-4378
RASGRP1	-4668	2119
RASGRP2	-2873	1508
RASGRP3	-3259	-2004
RBBP4	-565	-3282
RBBP5	328	-779
RBBP6	-354	-2825
RBCK1	694	-1357
RBL1	-3533	-3466
RBPJ	4017	-1118
RBX1	1368	-3241
RCC2	-1566	-2559
RCE1	-1412	-282
RCOR1	4190	-4864
RDH10	-1408	-3708
RDH11	2667	-3361
RDH13	-3871	-3495
RDH14	-3770	-3195
RELA	-542	2085
REST	276	2128
RGL1	3340	1731
RGL2	3258	-1001
RGS1	-1617	2271
RGS10	1707	-1251
RGS12	-4184	-4763
RGS14	2934	2215
RGS16	2737	991
RGS19	3398	-5018
RGS2	3294	-1424
RGS3	499	2448
RHEB	3356	-2334
RHOA	3753	1313
RHOB	390	-4992
RHOBTB2	-1691	-4257
RHOBTB3	-4186	-6232
RHOF	-4879	1911
RHOG	3858	860
RHOH	-3886	1825
RHOQ	3255	-1953
RHOT1	4352	-5271
RHOT2	-1688	-1902
RHPN1	-1624	-4217
RICTOR	-3383	1651
RING1	-1216	-1490
RIT1	4213	337
RND1	-481	-2463
RNF111	2267	779
RNF146	3975	1789
RNF2	1192	-1936
RNF20	2258	-799
RNF31	-3654	-4597
RNF41	3797	109
ROCK1	3246	-985
RPGRIP1L	-3711	456
RPS27A	-2201	-2138
RPS6	-1906	-1785
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA5	-4445	-514
RPS6KB2	218	1145
RPTOR	-3804	2134
RRAGA	2539	-1657
RRAGC	1856	-2585
RRAGD	4008	-6311
RRAS2	-3705	-678
RTN4	4237	-4674
RUNX1	3262	-4082
RUNX3	-4885	2402
RUVBL1	-2905	256
RYK	-3233	-5242
S1PR1	-3180	2436
S1PR2	-4394	63
S1PR4	1609	1429
SAMM50	-64	-2690
SAV1	212	-4821
SCAI	-2577	-3053
SCD	1416	-6126
SCMH1	-1799	1397
SCRIB	-862	-6408
SEC13	2266	-3749
SEH1L	-1875	-1615
SEL1L	2877	-2307
SEMA4F	-4272	-4174
SENP1	-2622	-1254
SFN	500	-5994
SFPQ	712	-1117
SGK1	1689	-6076
SH2B1	-2928	-1068
SH2B3	1358	1699
SH2D2A	-4888	2200
SH3BP1	666	2457
SH3GL1	3324	1075
SH3PXD2A	-2473	-5547
SHARPIN	2350	-4167
SHB	2414	2212
SHC1	1472	-2954
SHKBP1	4148	-2659
SHMT2	-1482	-4020
SHOC2	3161	-3532
SIRT6	2520	-4139
SKA2	-3080	-106
SKI	-4153	-2431
SKIL	-234	-3633
SKP1	1536	-2290
SLC1A5	2673	-1807
SLC38A9	906	-3360
SLC4A7	-4636	1208
SLK	2361	-6411
SMAD1	3872	-3272
SMAD2	1830	-1994
SMAD3	-4538	-4628
SMAD4	-2796	-6535
SMAD5	-1404	-5678
SMAD6	3456	-3209
SMAD7	-4617	-4450
SMARCA4	1758	2317
SMC3	-596	-1642
SMPD2	793	-918
SMPD3	-4824	2463
SMURF1	-780	1321
SMURF2	-3735	-3048
SNAP23	3937	-6016
SNW1	1979	946
SOCS1	1375	-2999
SOCS3	4399	2178
SOS1	-1748	-6775
SOS2	3740	-4105
SOX4	1807	-3220
SP1	3686	-3141
SPATA13	-2979	2314
SPC24	728	1272
SPDL1	-4409	-5240
SPEN	-89	-3162
SPOP	362	-6184
SPOPL	3795	-5721
SPPL2A	3118	-2234
SPPL2B	-1417	-6012
SPRED1	-2916	-6227
SPRED2	2927	521
SPRED3	-2159	-4087
SPRY1	727	-5532
SPRY2	-1386	-5919
SPTAN1	-4344	-1250
SPTBN1	-2529	-3924
SPTBN5	-1052	2344
SQSTM1	1438	-952
SRC	-2999	-4427
SREBF1	2701	-4015
SRF	3015	-1284
SRGAP1	2815	-6096
SRGAP3	-1738	-4649
SRRM1	-1535	-2963
ST3GAL3	158	-1055
ST3GAL4	2285	-4996
ST3GAL6	2794	-5427
STAG1	-1977	-863
STAM	397	770
STAM2	2488	-2181
STARD13	1001	2455
STAT1	-4529	2195
STAT3	3628	-3606
STAT5A	2943	-6427
STAT5B	2923	-3446
STAT6	2340	-3911
STBD1	2159	-6441
STIP1	-632	31
STK10	-1159	-3955
STK11	723	-5709
STK3	4146	-1290
STK38	358	-3207
STK4	-73	-1674
STMN1	-2924	-3648
STOM	2795	-3877
STRADA	740	-3296
STRADB	4019	-1429
STRAP	2849	-1805
STRN	1272	1051
STUB1	-330	-2168
STX5	3071	-1823
SUFU	3990	-3385
SYDE2	-280	-2606
SYK	4192	-5054
SYNGAP1	-3140	-2744
SYVN1	313	-5153
TAB2	2942	1892
TACC3	4334	-4182
TAGAP	-4847	2280
TAOK1	2096	942
TAOK3	1553	-3383
TAX1BP1	2418	-4470
TBL1XR1	1669	962
TCF12	-386	-4702
TCF7	-3643	2023
TCF7L2	-1917	-3431
TCIRG1	3087	-5082
TEC	3276	-5839
TERT	415	2491
TEX2	3599	-4038
TFDP1	3849	-1587
TFDP2	-4891	-4793
TFRC	468	-273
TGFA	4083	-3020
TGFB1	1959	-6
TGFBR1	486	-6163
TGFBR2	1359	-5224
TGIF1	-2933	-5815
TGIF2	-3603	-6609
THBS3	2988	-2835
THEM4	-4130	-6129
TIA1	-1628	-1498
TIAL1	-681	-277
TIAM2	-4087	-1035
TJP2	1460	-67
TLE2	-2409	-3959
TLE3	3898	-3798
TLE4	2883	635
TLN1	3876	191
TLR9	-1850	2292
TMED2	2424	-3656
TMED5	2955	85
TMEM59	3659	-5022
TMEM87A	-91	-4786
TMOD3	3099	1511
TMPO	3395	-2897
TNF	-2348	-3779
TNFAIP1	2369	-2621
TNFAIP3	-4067	-785
TNFRSF10A	561	-3935
TNFRSF10B	3754	1433
TNFRSF10D	4189	-5911
TNFRSF1A	4299	-4958
TNFSF10	1009	-2143
TNKS	-2959	-1583
TNKS2	-161	-449
TNRC6A	-1710	-5420
TNRC6B	-1353	2270
TOR1AIP1	2772	-65
TP53	-4034	-739
TPM3	3600	-3741
TPM4	4281	-2548
TRADD	-179	-1481
TRAF1	-4648	2318
TRAF2	-4539	-1442
TRAF6	-80	-6118
TRAK2	-136	-2549
TRIB3	-1802	1669
TRIM27	3651	-1744
TRIM33	-3001	-2091
TRIO	562	-5812
TRRAP	-2111	1860
TSC1	-638	1527
TSC2	-262	895
TTC21B	-4190	-4514
TUBA1B	2142	-1058
TULP3	-4593	-3271
TWF1	1164	-3202
TXNL1	3592	-1474
TYK2	3021	-3105
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2D1	4255	-1581
UBE2D3	3944	-373
UBE2M	3239	-3585
UBXN11	1664	-188
UCHL5	-2570	-6243
UHMK1	-1153	-1644
UHRF1BP1L	4120	571
USF1	1796	1871
USF2	2649	-624
USP13	-2120	-667
USP15	2481	686
USP21	-2215	-3841
USP34	-310	-4481
USP4	3446	-5610
USP7	2576	-2216
USP8	2632	-424
VAMP3	3698	1210
VAPA	4169	-5592
VAPB	687	-6771
VAV1	3499	-3184
VAV2	-1214	-643
VAV3	1824	-6342
VCL	3157	-5870
VCP	2902	-2411
VEGFA	3235	-2723
VHL	1262	1389
VIM	4364	-2247
VIPR1	-1904	-3480
VPS26A	2755	-287
VPS29	1034	9
VPS35	2779	-1928
VRK2	-3107	-559
VRK3	396	-1398
WASF1	4414	-1056
WASF2	3782	-2654
WASL	87	-4742
WDR11	-1848	-3212
WDR19	-2437	98
WDR35	-3799	-4696
WDR6	-2824	1495
WDR81	-2587	-4999
WDR83	1284	840
WDR91	-1721	-3596
WHAMM	-4800	-1672
WIPF1	177	-4382
WIPF2	2249	-2523
WNT1	-3087	-5360
WNT2B	-1176	-4534
WWOX	-4138	1732
WWP1	-3604	-1865
WWP2	3574	-718
XPO1	-371	-870
YBX1	1010	-364
YES1	-4772	-4415
YKT6	1980	-3331
YWHAB	2611	2125
YWHAE	4173	-4168
YWHAG	4294	-5545
YWHAH	3949	-2902
YWHAQ	-2362	-2908
YWHAZ	2200	541
YY1	169	-5165
ZAP70	-4650	2499
ZDHHC21	-2007	-3185
ZDHHC7	3940	-747
ZFYVE16	3342	-2416
ZFYVE9	-2566	-4766
ZNF217	1068	-5171
ZNRF3	-593	-5301
ZW10	8	160
ZWILCH	-4527	-103
ZWINT	-1436	-2742

---

---

Signaling by Receptor Tyrosine Kinases

Signaling by Receptor Tyrosine Kinases

metric	value
setSize	284
pMANOVA	6.36e-13
p.adjustMANOVA	1.06e-10
s.dist	0.256
s.RNA	0.253
s.meth	0.0417
p.RNA	3.55e-13
p.meth	0.23

Top 20 genes

Gene	RNA	meth
CLTC	4149	2477
FURIN	4191	2351
PTPRJ	3428	2365
ADAP1	3278	2385
ATP6V1A	4318	1580
ATP6V0B	3921	1604
PPP2CB	3381	1797
MAPK1	3249	1865
BRK1	2983	1970
MKNK1	3672	1538
TAB2	2942	1892
YWHAB	2611	2125
SHB	2414	2212
APH1B	2555	2056
RHOA	3753	1313
CBL	3241	1456
PTPN1	2254	2074
FOS	2120	2149
ADAM10	4030	976
RAC1	4031	971

Click HERE to show all gene set members

All member genes

	RNA	meth
AAMP	-1084	-5298
ABI1	3018	-1788
ABI2	-4048	-5451
ADAM10	4030	976
ADAM17	3634	774
ADAP1	3278	2385
ADORA2A	1094	-5935
AHCYL1	2658	-3553
AKT1	1234	-1942
AKT2	133	-141
AP2A1	2869	-4887
AP2M1	3936	20
AP2S1	3581	-3262
APH1A	1453	-6066
APH1B	2555	2056
ARF6	422	-3567
ARHGEF7	-1379	-5507
ATF1	2245	-2565
ATP6V0A1	4375	-5877
ATP6V0A2	-4811	689
ATP6V0B	3921	1604
ATP6V0C	4218	-4697
ATP6V0D1	4282	-1003
ATP6V0E1	3919	-2865
ATP6V0E2	-4420	-6625
ATP6V1A	4318	1580
ATP6V1B2	4178	-4232
ATP6V1C1	3887	655
ATP6V1D	4174	-1234
ATP6V1E1	3588	-3948
ATP6V1F	2338	1350
ATP6V1G2	-3312	-3714
ATP6V1H	3607	-1695
BAIAP2	-72	1977
BAX	2357	-3623
BRAF	403	-4347
BRK1	2983	1970
CALM1	-626	-5019
CAV1	619	-2432
CBL	3241	1456
CDC42	3268	-2719
CDK5	3929	-506
CDK5R1	-346	-2113
CHD4	-1351	-4634
CHEK1	-741	-211
CLTA	3788	-5077
CLTC	4149	2477
COL9A2	-3430	-2895
CREB1	-430	-672
CRK	4091	-4581
CRKL	1387	-906
CSK	1990	862
CTNNB1	2626	-1691
CTNND1	-2821	1566
CUL5	265	-3077
CYBA	2922	1006
CYFIP1	4295	-6630
CYFIP2	-3754	2232
DIAPH1	-283	1033
DLG4	4153	-3021
DNAL4	1142	-45
DNM1	1225	-5619
DNM2	2448	738
DOCK7	-708	-5883
DUSP3	4305	-1798
DUSP4	-1957	-3176
DUSP6	1570	-6763
DUSP7	-960	-1322
EGR1	1023	-163
EGR2	-450	-2628
ELMO1	2547	-2714
ELMO2	1591	1326
EP300	2471	-4509
EPN1	3595	-2171
EPS15	1457	-654
EPS15L1	1251	-3901
ERBB2	-4865	-5145
ESRP2	-2936	-6611
FER	541	-3332
FES	4278	-6334
FGF9	-2970	1634
FGFBP3	-3207	1
FGFRL1	-4558	-2409
FLT3LG	-3495	1573
FOS	2120	2149
FOSB	418	-332
FOSL1	4028	737
FRS2	-1025	-1999
FRS3	3166	-2329
FURIN	4191	2351
FYN	-4495	1957
GAB2	3629	-6153
GALNT3	557	-2941
GGA3	1326	450
GRAP2	1736	-5763
GRB10	4386	-70
GRB2	4320	-2295
GTF2F1	1854	-1723
GTF2F2	2104	-2885
HBEGF	1889	-6428
HGS	1647	2123
HNRNPF	1366	-58
HNRNPH1	-2604	-1020
HNRNPM	1976	-4945
HRAS	-1008	-4780
HSP90AA1	411	-781
HSPB1	582	-4137
ID1	1843	-3980
ID2	-4082	566
ID3	-3355	1995
IGF1R	2394	-4939
INSR	3730	-2668
IRS1	533	-4060
IRS2	3903	-5410
ITCH	407	-1366
ITGA2	1478	-3856
ITGAV	2457	-5201
ITPR1	-2478	-3278
ITPR2	2315	-6107
ITPR3	-3717	-3427
JAK2	857	-1751
JUNB	2850	-3031
JUND	478	-1239
KIDINS220	3009	189
KRAS	1276	440
LAMA2	-3504	-1315
LAMB2	156	-2207
LCK	-4596	2489
LRIG1	-3766	-3314
LYL1	3697	-6435
MAP2K1	4183	-698
MAP2K2	2840	-3962
MAP2K5	1370	-3572
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPKAP1	1911	1057
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MEF2A	3571	-2822
MEF2D	-929	-3018
MEMO1	4063	-3910
MKNK1	3672	1538
MLST8	117	287
MST1	270	1514
MST1R	-1712	-4446
MTOR	-3429	-1813
MXD4	-4252	-2602
NAB1	416	-2731
NAB2	-3772	989
NCBP1	-1807	-3745
NCBP2	-3329	-4067
NCF4	4298	-6732
NCK1	-4361	-1408
NCK2	1848	-4310
NCKAP1L	3360	-6178
NCOR1	2341	-3738
NCSTN	4254	-3821
NEDD4	2511	-5611
NELFB	115	1822
NOS3	-620	-1770
NTRK1	-2715	898
PAG1	2019	262
PAK1	3703	-3995
PAK2	3682	-3961
PCSK5	1812	-4883
PDE3B	-4275	-4025
PDPK1	2474	167
PGF	-1789	1959
PIK3CA	1703	-1445
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R3	-4692	-22
PIK3R4	-1215	-3425
PLCG1	-4158	-3541
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5D	771	-4349
PRKACA	4378	-6032
PRKACB	-4656	455
PRKCA	356	810
PRKCB	3029	-4518
PRKCD	4154	584
PRKCE	-2638	-5632
PRKCZ	-4470	-5220
PRR5	-4676	-1591
PSEN1	3540	-3407
PSEN2	-2508	-5155
PSENEN	2260	-3620
PTBP1	-68	-1843
PTK2	1629	920
PTK2B	3527	40
PTPN1	2254	2074
PTPN11	2038	-2302
PTPN12	3660	-1077
PTPN18	2482	693
PTPN2	3316	-3701
PTPN6	2452	-4586
PTPRJ	3428	2365
PTPRU	-816	1974
PXN	2531	-5712
RAB4A	3532	-5479
RAB4B	1028	1318
RAC1	4031	971
RALA	864	-262
RALB	3814	-1081
RALGDS	-4770	1254
RANBP10	816	-5295
RANBP9	2299	-1361
RAP1A	3148	323
RAP1B	1058	-1031
RAPGEF1	-3458	1868
RASA1	664	-167
REST	276	2128
RHOA	3753	1313
RICTOR	-3383	1651
RIT1	4213	337
RNF41	3797	109
ROCK1	3246	-985
RPS27A	-2201	-2138
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA5	-4445	-514
SGK1	1689	-6076
SH2B3	1358	1699
SH2D2A	-4888	2200
SH3GL1	3324	1075
SHB	2414	2212
SHC1	1472	-2954
SOCS1	1375	-2999
SOS1	-1748	-6775
SPRED1	-2916	-6227
SPRED2	2927	521
SPRY1	727	-5532
SPRY2	-1386	-5919
SRC	-2999	-4427
SRF	3015	-1284
STAM	397	770
STAM2	2488	-2181
STAT1	-4529	2195
STAT3	3628	-3606
STAT5A	2943	-6427
STAT5B	2923	-3446
STAT6	2340	-3911
STMN1	-2924	-3648
STUB1	-330	-2168
TAB2	2942	1892
TCF12	-386	-4702
TCIRG1	3087	-5082
TEC	3276	-5839
TGFA	4083	-3020
THBS3	2988	-2835
THEM4	-4130	-6129
TIA1	-1628	-1498
TIAL1	-681	-277
TLR9	-1850	2292
TRIB3	-1802	1669
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
USP8	2632	-424
VAV1	3499	-3184
VAV2	-1214	-643
VAV3	1824	-6342
VEGFA	3235	-2723
VRK3	396	-1398
WASF1	4414	-1056
WASF2	3782	-2654
WWOX	-4138	1732
WWP1	-3604	-1865
YES1	-4772	-4415
YWHAB	2611	2125

---

---

Disease

Disease

metric	value
setSize	930
pMANOVA	7.12e-12
p.adjustMANOVA	1.03e-09
s.dist	0.138
s.RNA	0.128
s.meth	0.052
p.RNA	1.27e-10
p.meth	0.00912

Top 20 genes

Gene	RNA	meth
CLTC	4149	2477
FURIN	4191	2351
ENTPD1	3775	2446
QKI	4147	2193
ANTXR2	3160	2471
TLR5	4260	1823
GNG5	4043	1920
ACTG1	3901	1793
MYH9	2789	2182
PPP2CB	3381	1797
MAPK1	3249	1865
BRD4	2344	2511
BRK1	2983	1970
DAD1	2346	2452
BCL2L11	3187	1781
YWHAB	2611	2125
PPP1CB	3004	1839
GLB1	3992	1368
PAPSS1	4151	1297
PSMA7	3028	1752

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
ABCA1	2459	-6487
ABCB6	2624	-6503
ABCD4	-2830	-4648
ABI1	3018	-1788
ABI2	-4048	-5451
ABL1	63	-4891
ACACA	2039	-164
ACTB	4156	-4515
ACTG1	3901	1793
ACTR2	3481	-3374
ACTR3	3448	-2917
ACY1	-1382	-1933
ADAM10	4030	976
ADAM17	3634	774
ADAMTS10	-4118	-5260
ADAMTS13	-1309	958
ADAMTS17	-1134	463
ADAMTS6	-2253	1076
ADAMTSL4	3263	1378
ADAMTSL5	-2776	-6404
ADCY4	2020	-6389
ADCY7	-980	-5596
ADCY9	33	-2618
ADM	4359	-6151
ADORA2A	1094	-5935
ADRB2	-4624	-3531
AGGF1	2507	-3806
AGK	-4757	-3004
AGRN	-4553	-2304
AGTRAP	4122	-6548
AHCY	146	-5043
AHCYL1	2658	-3553
AKAP9	-1528	-3186
AKT1	1234	-1942
AKT1S1	3477	-2319
AKT2	133	-141
ALG11	-1067	-549
ALG12	849	-1300
ALG14	2265	1103
ALG2	-391	-625
ALG3	-392	-2680
ALG6	513	-4449
ALG8	-1083	-3591
ALG9	-3428	-1148
ANAPC1	-4659	403
ANAPC10	-1520	-6111
ANAPC11	2490	344
ANAPC15	4132	-1379
ANAPC16	-640	-4507
ANAPC2	-2390	-1007
ANAPC4	-2075	-1696
ANAPC5	-4080	-2530
ANAPC7	-1573	1560
ANTXR2	3160	2471
AP1B1	3995	-463
AP1G1	1397	516
AP1M1	2798	-2408
AP1S3	-1681	-5455
AP2A1	2869	-4887
AP2M1	3936	20
AP2S1	3581	-3262
AP3B1	3779	-3148
APBB1IP	4003	-5120
APC	1073	-4775
APH1A	1453	-6066
APH1B	2555	2056
APP	4249	-5300
ARF1	4184	-6686
ARID4A	1303	-5475
ARID4B	-13	-1226
ARPC1B	4291	-2022
ARPC2	3191	-3647
ARPC3	3729	-3767
ARPC5	3968	-3837
ARRB1	632	-6363
ARRB2	3860	-2243
ARSB	3290	-5722
ATG7	3647	569
ATP1A1	910	-365
ATP1A3	-4414	-462
ATP1B1	-3130	111
ATP1B3	-416	1223
ATP6V1H	3607	-1695
AXIN1	-3703	-5655
B2M	-2195	-2389
B3GALT6	-1337	2030
B3GAT3	-879	646
B4GALT1	1540	-160
B4GALT7	-2369	482
B4GAT1	-1725	451
BAD	2904	-1382
BAG4	3756	-3089
BAIAP2	-72	1977
BANF1	-1439	-709
BARD1	-1019	-2910
BCL2L1	3979	1306
BCL2L11	3187	1781
BCR	-2261	-6682
BECN1	2690	459
BIN2	2264	-2805
BRAF	403	-4347
BRAP	2076	-3662
BRCA1	2542	-4609
BRD4	2344	2511
BRK1	2983	1970
BRMS1	2116	800
BSG	4245	-1562
BTD	-4787	146
BTRC	-1493	-2427
C1GALT1	-1285	-3509
C1QBP	-275	-2507
C3AR1	3573	-6729
CALM1	-626	-5019
CALR	2586	-3753
CAMK2D	-4581	-2867
CAMK2G	601	2354
CAMK4	-3531	1482
CANX	2151	-4839
CAPN1	3902	-6119
CAPN2	336	-1533
CAPNS1	3394	-2032
CASP1	1501	-1448
CASP8	-4285	387
CASP9	3366	-234
CAST	3666	-5687
CBL	3241	1456
CBX1	1770	-1720
CCNC	589	-1138
CCND1	-2214	-6213
CCND2	-4535	-5700
CCND3	3245	905
CCNE1	-4514	-3403
CCNE2	1953	-3396
CCNH	243	-3754
CCNK	923	-6142
CCNT1	-3292	1773
CD247	-4880	2098
CD320	-3400	103
CD4	-1648	-6372
CDC16	-1877	-4152
CDC23	-4259	-707
CDC25A	938	-1711
CDC25B	-4694	2116
CDC25C	1865	-2877
CDC42	3268	-2719
CDK2	-1522	1018
CDK4	-4235	-1295
CDK5	3929	-506
CDK5R1	-346	-2113
CDK6	-2015	-2864
CDK7	1983	275
CDK8	-594	-5509
CDK9	-1171	1524
CDKN1A	1646	-3540
CDKN1B	-2723	-862
CDKN2A	-1595	-4511
CEBPD	4044	-5142
CHD3	-3413	422
CHD4	-1351	-4634
CHMP1A	2269	2118
CHMP2A	4024	-297
CHMP2B	2250	-4000
CHMP3	3769	-2694
CHMP4A	763	458
CHMP4B	4075	-4297
CHMP5	1850	-2010
CHMP6	2138	-2539
CHMP7	-2991	-1608
CHST14	357	-6351
CHSY1	3638	-4487
CHUK	3543	1343
CLCN6	703	-775
CLTA	3788	-5077
CLTC	4149	2477
CNTRL	-2072	-6676
COMT	3725	-6677
CORO1A	1967	2237
CPSF4	-3261	134
CPSF6	-1897	2374
CRBN	-1918	919
CREB1	-430	-672
CREBBP	1153	-5804
CRK	4091	-4581
CSK	1990	862
CSNK1A1	3419	769
CTBP1	-2010	2394
CTDP1	2503	1112
CTNNB1	2626	-1691
CTNND1	-2821	1566
CTSA	4412	-4847
CTSL	1504	-6671
CUL1	-4281	-5146
CUL5	265	-3077
CUX1	4142	-2129
CXCR4	-19	-1660
CYBA	2922	1006
CYFIP1	4295	-6630
CYFIP2	-3754	2232
CYP2R1	-3508	-1915
CYP2U1	-4687	-4531
CYP4F22	-4840	-2371
DAD1	2346	2452
DAG1	-2376	-146
DAXX	-3855	-450
DBP	-4352	-1027
DCXR	-100	-2013
DDX5	-3465	1288
DERL1	-3060	123
DERL2	987	-2287
DERL3	-2415	-2550
DHDDS	-673	-4895
DNAJC3	3828	-2353
DNMT1	-4835	1294
DNMT3A	-911	-6002
DNMT3B	1541	1185
DOLK	-1085	-2245
DPAGT1	678	650
DPEP2	-808	-6530
DPM1	482	-2366
DPM2	1751	-1939
DPM3	823	-2637
DUSP10	-503	-1469
DUSP16	-2082	-2622
DUSP6	1570	-6763
DUSP7	-960	-1322
DUT	-1865	1287
DVL1	0	-4520
DVL2	-4172	-1356
DVL3	2219	-3704
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNLL1	2378	-3319
DYNLL2	-1189	214
E2F1	2589	-1005
E2F2	3922	386
E2F3	2768	-2884
EDEM2	3982	-3093
EED	-3235	-1174
EEF2	90	2127
EIF2AK2	-3128	-3645
ELL	1886	574
ELMO1	2547	-2714
ELMO2	1591	1326
ENO1	4084	-6654
ENTPD1	3775	2446
ENTPD5	-1913	-4305
EP300	2471	-4509
EPS15	1457	-654
ERBB2	-4865	-5145
ERCC2	1210	-594
ERCC3	-2534	969
ERLEC1	217	-2711
ERLIN1	4076	899
ERLIN2	4104	-4042
ESR2	-3194	-2661
ETV6	2110	-6394
EXT1	3030	-5359
EXT2	-437	-1799
EZH2	-3415	-20
F12	4406	-1719
FADD	2211	-6328
FAU	-124	-3862
FBXW7	-2055	-5428
FDX1	579	-3747
FDXR	1776	-3448
FEN1	-3865	-56
FGF9	-2970	1634
FGFR1OP2	3455	-2734
FGR	3853	-5292
FIP1L1	-2603	-2274
FKBP1A	4177	-4465
FKBP4	263	-4442
FLT3LG	-3495	1573
FOXO1	-3290	-5036
FOXO3	3966	711
FRS2	-1025	-1999
FURIN	4191	2351
FUT8	-3421	-2455
FXR1	2034	-1166
FXYD7	-2325	-6745
FYN	-4495	1957
FZD5	4411	-2513
FZD6	-2030	-6235
FZD7	-2024	-3834
FZD8	-2285	-6560
FZR1	-670	-758
G6PC3	1360	-6318
GAA	3545	-3801
GAB2	3629	-6153
GALE	1893	-105
GALK1	4060	-2705
GALNS	3034	-854
GALNT12	-3477	-5876
GALNT3	557	-2941
GALT	-3174	-325
GANAB	-317	-3501
GATAD2A	999	-256
GATAD2B	-535	-2871
GCLC	-4505	-1829
GCLM	2080	-248
GFPT1	-2014	-2828
GGCX	2003	-3236
GGT1	4376	-6607
GIPR	-4745	-2380
GLB1	3992	1368
GNAI2	3616	-1747
GNAI3	3536	-909
GNAS	3508	951
GNB1	3736	-2920
GNB2	3650	-309
GNB4	3163	-6007
GNB5	163	1821
GNE	-1580	-4921
GNG2	-2538	-3847
GNG3	285	2231
GNG4	-649	2073
GNG5	4043	1920
GNG7	-1581	-4773
GNGT2	-4735	2438
GNS	4348	-571
GOLGA2	2513	1847
GOLGA4	-1217	-155
GOLGB1	-1635	-3196
GPC2	-1277	-6477
GPS2	-293	-857
GRB2	4320	-2295
GRSF1	1966	27
GSDMD	614	-3378
GSK3A	3415	-2192
GSK3B	2756	736
GSS	224	-1739
GTF2A1	865	271
GTF2A2	3006	-1036
GTF2B	1193	-3218
GTF2E2	2276	-184
GTF2F1	1854	-1723
GTF2F2	2104	-2885
GTF2H3	-672	1025
GTF2H4	-876	-2761
GTF2H5	1345	691
GUSB	3389	-4967
GYG1	4157	-5541
GYS1	3067	-1092
HBEGF	1889	-6428
HDAC1	184	-1016
HDAC10	721	-1304
HDAC11	1771	-3595
HDAC2	2129	-46
HDAC3	1727	-3771
HDAC4	4126	-3817
HDAC5	1746	-3144
HDAC7	2465	-4900
HEXA	391	-4273
HEXB	4022	-5777
HEY2	-3420	2330
HGS	1647	2123
HGSNAT	583	2126
HHAT	-3216	-5389
HK1	4188	479
HLA-A	-771	-5991
HLCS	-4516	1551
HMG20B	1802	-3649
HMGA1	32	802
HMGB1	-86	-1263
HNRNPK	3259	-2386
HRAS	-1008	-4780
HRH2	4395	-6490
HSP90AA1	411	-781
HSP90AB1	-2171	-5745
HSPA1A	3613	-3825
HYAL1	1475	-6777
IDH1	4409	-2333
IDUA	-1794	932
IFNAR1	3813	-490
IFNAR2	2778	-3573
IFNGR1	4301	310
IFNGR2	4279	-6331
IKBKB	-1640	-3894
IL6R	3645	-6410
IMPDH1	4313	-750
IMPDH2	-3507	446
IPO5	-3864	1869
IQGAP1	3661	1271
IRS1	533	-4060
IRS2	3903	-5410
ISG15	-4701	1894
ITGA4	-4122	1419
ITPR1	-2478	-3278
ITPR2	2315	-6107
ITPR3	-3717	-3427
JAK1	-4072	-1022
JAK2	857	-1751
JUN	1286	69
KANK1	-1183	-270
KAT2A	-3970	-5050
KAT2B	-722	-1588
KCNJ11	-1226	-2105
KDM1A	-3266	900
KHK	-2309	-1547
KPNA1	400	-2889
KPNA2	-2190	-874
KPNA3	295	-897
KPNA4	1858	1716
KPNA5	-4625	-572
KPNB1	776	-2176
KRAS	1276	440
KSR1	1477	2466
LCK	-4596	2489
LFNG	-2806	1932
LIG1	-4124	-4259
LIG4	2040	-949
LMBRD1	2725	-156
LMNA	1348	-6474
LMNB1	4342	-942
LRP5	1538	1949
LRP6	180	-4544
LRRFIP1	2568	-1040
MAML1	2088	-5348
MAML2	-189	-2078
MAML3	4123	-4054
MAN1B1	-1477	2249
MAN2A1	-418	-4486
MAP2K1	4183	-698
MAP2K2	2840	-3962
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAP3K11	3325	-2732
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK8	-3265	6
MAPKAP1	1911	1057
MARK3	3976	-3461
MBD3	-170	1673
MCCC1	-3067	-4716
MCCC2	-4605	1857
MDM2	1551	-1318
MGAT1	2546	1169
MGAT2	507	-1666
MGAT4A	-1741	-2254
MGAT4B	3961	-6439
MGAT5	-918	-5572
MIB1	-896	-2718
MLST8	117	287
MMAA	-4375	-3965
MMAB	-3102	-850
MMACHC	-2175	-266
MMADHC	2563	-3748
MNAT1	-2935	311
MOGS	-913	-2356
MPDU1	3413	-1260
MPI	-3963	-5890
MPRIP	-4075	755
MSH2	-4382	83
MSH3	2309	-924
MSH6	-655	1672
MTA2	-2350	1649
MTA3	-3267	-1740
MTOR	-3429	-1813
MTR	-4685	448
MTRR	629	-694
MUC1	2718	-5557
MUC12	-3930	-5807
MUC5B	-1389	2353
MUTYH	-4105	-2996
MVB12A	3199	272
MYD88	3649	-1927
MYH9	2789	2182
MYO18A	-1185	-6701
MYO9B	2637	687
NAGLU	-1444	-5716
NAPEPLD	-2296	-4964
NCBP1	-1807	-3745
NCBP2	-3329	-4067
NCK1	-4361	-1408
NCKAP1L	3360	-6178
NCKIPSD	97	-4332
NCOR1	2341	-3738
NCOR2	3557	-4281
NCSTN	4254	-3821
NDC1	-4789	-5228
NEDD4L	3485	-5066
NEIL3	373	248
NELFA	-1157	35
NELFB	115	1822
NELFCD	-1954	2444
NELFE	1342	1377
NEU1	4167	-3878
NF1	985	-2145
NFKB2	-367	388
NFKBIA	2851	1159
NHLRC1	-1716	-5836
NLRP3	4089	-6357
NMT1	1558	-3001
NMT2	-4704	1340
NOTCH1	1743	1722
NOTCH4	-1593	-6455
NOXA1	-1664	-5872
NR3C1	162	-2420
NR4A1	-2128	657
NTHL1	-2691	-5795
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
NUS1	3476	-9
OGG1	-2596	-3033
OS9	4087	-975
P2RX4	3328	174
PABPN1	-169	-3743
PACS1	-2857	-4252
PAK2	3682	-3961
PAPSS1	4151	1297
PARP1	-4548	-5521
PARP10	-2818	2302
PARP14	-4614	864
PARP16	-4591	678
PARP4	1574	-715
PARP6	-1506	-3268
PARP8	-2825	-759
PARP9	-1314	1117
PC	4293	-5175
PCCB	-2627	-6219
PDCD6IP	2695	-3917
PDPK1	2474	167
PEBP1	-4246	-152
PGM1	2316	-4799
PHB	-894	-3178
PHF21A	4265	-3398
PIK3AP1	3445	-4753
PIK3CA	1703	-1445
PIK3CD	2422	2189
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R3	-4692	-22
PIK3R4	-1215	-3425
PIM1	3377	-5227
PLCG1	-4158	-3541
PLCG2	1884	-2562
PLK2	-827	-6257
PML	-2938	549
PMM2	428	-2687
PMS2	-1678	1574
POLA2	-4432	-593
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
POM121	-2766	-1787
POM121C	-2305	-4315
POMGNT1	-4644	-826
POMT1	-2925	1390
POMT2	193	-669
PPIA	-2133	490
PPP1CB	3004	1839
PPP1CC	2581	-754
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5A	2347	381
PPP2R5B	2831	-6343
PPP2R5C	-4242	2376
PPP2R5D	771	-4349
PPP2R5E	-217	-2288
PRDX1	2981	-877
PRDX2	1157	-5158
PRIM1	-3653	396
PRIM2	-1700	-18
PRKACA	4378	-6032
PRKACB	-4656	455
PRKAR1A	3924	-201
PRKAR1B	3514	731
PRKAR2A	2493	-4298
PRKCSH	1991	-3007
PRR5	-4676	-1591
PSEN1	3540	-3407
PSEN2	-2508	-5155
PSENEN	2260	-3620
PSIP1	-3416	-4249
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PSTPIP1	3462	1135
PTEN	3844	-1100
PTGER2	448	-5853
PTGER4	-4508	1153
PTGES3	1450	-1810
PTK2	1629	920
PTPN11	2038	-2302
PTPN12	3660	-1077
PYCARD	3942	-6598
QKI	4147	2193
RAB5A	3035	-1686
RAB7A	4002	-5570
RAC1	4031	971
RAC2	1962	-868
RAE1	1963	-39
RAF1	3488	-314
RAN	-2142	1257
RANBP1	-3377	-2212
RANBP2	-273	-4704
RANGAP1	-4525	1644
RAP1A	3148	323
RAP1B	1058	-1031
RB1	3985	-4740
RBBP4	-565	-3282
RBPJ	4017	-1118
RBX1	1368	-3241
RCC1	543	-1845
RCOR1	4190	-4864
RELA	-542	2085
REST	276	2128
RFT1	1549	147
RHBDF2	1487	-4959
RHOG	3858	860
RICTOR	-3383	1651
RNF185	2681	-2775
RNF213	-4630	2228
RNF5	-1999	-4625
RNGTT	1007	-2952
RNMT	-4139	2172
ROCK1	3246	-985
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPN1	3580	-2841
RPN2	3058	-688
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS6KB2	218	1145
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
S1PR1	-3180	2436
SAP18	1882	-3579
SAP30	3742	-2185
SAP30L	1978	-233
SDC4	2758	1193
SEC13	2266	-3749
SEH1L	-1875	-1615
SEL1L	2877	-2307
SFPQ	712	-1117
SH3GL1	3324	1075
SHC1	1472	-2954
SHOC2	3161	-3532
SIGMAR1	-2514	306
SIN3A	-3818	-4151
SKP1	1536	-2290
SKP2	-2759	-1566
SLC11A2	74	-4073
SLC12A6	3627	-2521
SLC16A1	1626	576
SLC17A5	1875	-3631
SLC20A2	-4587	-345
SLC22A5	2925	-5659
SLC24A4	3432	-6556
SLC25A4	-4606	-2062
SLC26A2	-873	-2627
SLC27A4	795	-6752
SLC29A3	1977	2162
SLC2A1	-4221	1930
SLC2A9	2871	-6223
SLC33A1	-644	-2395
SLC35A1	3104	-4021
SLC35A3	-3219	-4409
SLC35C1	880	-5366
SLC35D1	-2187	-2789
SLC37A4	-1973	-3038
SLC39A4	1630	494
SLC3A2	1993	-1667
SLC5A5	-1625	-5772
SMAD2	1830	-1994
SMAD3	-4538	-4628
SMAD4	-2796	-6535
SND1	1338	-1905
SNF8	2387	-2157
SNW1	1979	946
SOD2	1587	573
SOS1	-1748	-6775
SPON2	-4842	1081
SPRED1	-2916	-6227
SPRED2	2927	521
SPRED3	-2159	-4087
SPTBN1	-2529	-3924
SRC	-2999	-4427
SRD5A3	1390	442
SSRP1	-4179	-2441
ST3GAL1	-2406	1767
ST3GAL2	3958	-2686
ST3GAL3	158	-1055
ST3GAL4	2285	-4996
ST6GAL1	-4715	1948
ST6GALNAC3	4221	145
ST6GALNAC4	-207	-5981
STAM	397	770
STAM2	2488	-2181
STAT1	-4529	2195
STAT2	-3894	-3295
STAT3	3628	-3606
STAT5A	2943	-6427
STAT5B	2923	-3446
STRN	1272	1051
STT3A	1442	-4222
STX1A	-1213	-2461
STX1B	-886	-6167
SUDS3	1652	-1851
SUGT1	475	594
SUMO1	2903	-3986
SUPT16H	-4301	-3702
SUPT4H1	930	-1899
SUPT5H	-2108	-3641
SYK	4192	-5054
SYVN1	313	-5153
TAF10	3039	1606
TAF11	-881	-719
TAF12	3552	-1765
TAF13	3098	-908
TAF15	-2008	-3109
TAF2	-1828	-4149
TAF3	-559	-3002
TAF4	-516	-6161
TAF4B	-2666	-1647
TAF5	-1350	1150
TAF6	-2367	1804
TAF7	673	-3426
TAF9	388	1714
TALDO1	4392	-5245
TBK1	1067	-4616
TBL1XR1	1669	962
TBXAS1	4073	-6709
TCEA1	-309	-4211
TCF7L2	-1917	-3431
TFDP1	3849	-1587
TFDP2	-4891	-4793
TGFA	4083	-3020
TGFB1	1959	-6
TGFBR1	486	-6163
TGFBR2	1359	-5224
TICAM1	2569	-2136
TIRAP	2210	-5182
TLN1	3876	191
TLR1	4106	-6127
TLR2	4206	-6586
TLR3	-4406	-5820
TLR5	4260	1823
TLR6	4058	-802
TLR9	-1850	2292
TNKS	-2959	-1583
TNKS2	-161	-449
TPMT	1608	-5097
TPR	-2242	-973
TPST1	4286	-2233
TPST2	2256	-2387
TRADD	-179	-1481
TRAF2	-4539	-1442
TRAF3	-1701	2379
TRIM24	1322	-5752
TRIM27	3651	-1744
TRIM28	-1538	1191
TRIP11	-187	1568
TSC2	-262	895
TSG101	3430	-5032
TUBB	-2209	1395
TXN	3732	284
TXNIP	-3347	-2777
TXNRD1	3685	-4647
TYK2	3021	-3105
UBA52	349	752
UBAP1	3980	-2481
UBB	2759	-1321
UBC	1618	-2568
UBE2C	1933	1091
UBE2D1	4255	-1581
UBE2E1	2822	-5882
UBE2I	-245	233
UBE2S	1766	2449
UNC93B1	1479	-4358
UVRAG	-3092	-3344
VAMP1	-2908	-1537
VAMP2	-4559	-2770
VAV1	3499	-3184
VAV2	-1214	-643
VAV3	1824	-6342
VCL	3157	-5870
VCP	2902	-2411
VEGFA	3235	-2723
VHL	1262	1389
VIPR1	-1904	-3480
VPS25	3332	1235
VPS28	1488	-2471
VPS33B	-630	-2464
VPS36	-2165	-2008
VPS37A	2668	-3512
VPS37B	1356	-6110
VPS37C	3572	421
VPS4A	248	118
VTA1	2506	-3898
WASF1	4414	-1056
WASF2	3782	-2654
WASL	87	-4742
WDR48	-4427	-5481
WIPF1	177	-4382
WIPF2	2249	-2523
XPO1	-371	-870
XRCC4	2821	-3706
XRCC5	2075	-3770
XRCC6	-1335	376
YES1	-4772	-4415
YWHAB	2611	2125
YWHAE	4173	-4168
ZBP1	-4869	-410
ZC3HAV1	-3578	1635
ZCRB1	150	2291
ZFYVE9	-2566	-4766
ZMYM2	1129	-896

---

---

Signaling by Interleukins

Signaling by Interleukins

metric	value
setSize	263
pMANOVA	1.38e-11
p.adjustMANOVA	1.79e-09
s.dist	0.253
s.RNA	0.253
s.meth	0.0151
p.RNA	2.56e-12
p.meth	0.677

Top 20 genes

Gene	RNA	meth
SOCS3	4399	2178
LCP1	3793	2024
IL19	2820	2517
PPP2CB	3381	1797
MAPK1	3249	1865
NOD2	3833	1528
TNFRSF1B	2421	2416
TAB2	2942	1892
ITGB2	4114	1322
BATF	2612	2070
PSMA7	3028	1752
PIK3CD	2422	2189
BCL2L1	3979	1306
PSMD1	3112	1660
CNN2	2764	1735
CHUK	3543	1343
CBL	3241	1456
FOS	2120	2149
PSME3	3715	1116
SMARCA4	1758	2317

Click HERE to show all gene set members

All member genes

	RNA	meth
AIP	-1061	1761
AKT1	1234	-1942
ALOX5	4150	-6082
APP	4249	-5300
ARF1	4184	-6686
ATF1	2245	-2565
BATF	2612	2070
BCL2	-1421	2361
BCL2L1	3979	1306
BCL6	4248	-299
BIRC5	1291	-84
BRWD1	-3183	-3884
BTRC	-1493	-2427
CANX	2151	-4839
CAPZA1	3648	572
CASP1	1501	-1448
CASP3	-208	-2764
CBL	3241	1456
CCND1	-2214	-6213
CCR1	4074	-6480
CD4	-1648	-6372
CDC42	3268	-2719
CDKN1A	1646	-3540
CEBPD	4044	-5142
CFL1	3683	912
CHUK	3543	1343
CISH	1836	1748
CNN2	2764	1735
CREB1	-430	-672
CRK	4091	-4581
CRKL	1387	-906
CSF1	-622	-5924
CTF1	1521	-5738
CUL1	-4281	-5146
CXCL2	2093	-6755
DUSP3	4305	-1798
DUSP4	-1957	-3176
DUSP6	1570	-6763
DUSP7	-960	-1322
FBXW11	2510	-6747
FOS	2120	2149
FOXO1	-3290	-5036
FOXO3	3966	711
FYN	-4495	1957
GAB2	3629	-6153
GATA3	-4799	1861
GRB2	4320	-2295
GSDMD	614	-3378
GSTO1	4196	-170
HIF1A	3219	-3349
HMGB1	-86	-1263
HNRNPA2B1	1133	-2665
HNRNPF	1366	-58
HSP90AA1	411	-781
HSP90B1	647	-1371
HSPA9	-3436	-200
ICAM1	2796	-5333
IKBKB	-1640	-3894
IL10RA	-3866	1263
IL10RB	4239	-6138
IL12A	-2552	-5748
IL12RB1	-4755	-1444
IL12RB2	-4683	-5603
IL15	-1531	-5098
IL15RA	826	-3679
IL16	-3409	656
IL17C	-2074	-1115
IL17RA	4257	-3604
IL17RC	55	-1157
IL18BP	-3851	-5936
IL18R1	1399	475
IL19	2820	2517
IL1RAP	3063	-456
IL21R	-4834	401
IL23A	-3838	-6478
IL27RA	1165	-1230
IL2RA	-2295	-6462
IL2RB	-4882	2472
IL32	-3617	2512
IL4R	3174	-4452
IL6R	3645	-6410
IL6ST	1415	1094
INPP5D	-1207	-3735
INPPL1	4166	-2224
IRAK2	-3327	-1457
IRAK3	4208	-6295
IRF4	-3062	1782
IRS1	533	-4060
IRS2	3903	-5410
ITGB2	4114	1322
JAK1	-4072	-1022
JAK2	857	-1751
JUN	1286	69
JUNB	2850	-3031
LCK	-4596	2489
LCP1	3793	2024
LGALS9	979	-6589
LMNB1	4342	-942
MAP2K1	4183	-698
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAP3K3	3850	64
MAP3K7	761	-2089
MAP3K8	2489	1442
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPK8	-3265	6
MAPK9	-2259	872
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MEF2A	3571	-2822
MIF	-1146	-2943
MTAP	-1778	-5878
MUC1	2718	-5557
MYD88	3649	-1927
NFKB2	-367	388
NFKBIA	2851	1159
NFKBIB	-48	-3368
NKIRAS1	116	-3490
NKIRAS2	4346	-5039
NOD1	-4837	-5170
NOD2	3833	1528
OSM	3426	-3652
P4HB	3831	-1549
PAK2	3682	-3961
PDCD4	-4586	1941
PELI1	2800	-3839
PELI2	3750	-2561
PELI3	3383	-4323
PIK3CA	1703	-1445
PIK3CD	2422	2189
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R3	-4692	-22
PIM1	3377	-5227
PITPNA	2860	-2752
POU2F1	470	733
PPIA	-2133	490
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5D	771	-4349
PRKACA	4378	-6032
PRTN3	2825	-6448
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTK2B	3527	40
PTPN11	2038	-2302
PTPN12	3660	-1077
PTPN13	-3534	-6489
PTPN18	2482	693
PTPN2	3316	-3701
PTPN23	-372	-3227
PTPN4	-4818	-3156
PTPN6	2452	-4586
PTPN7	-4023	-1888
PTPN9	2799	-1265
RALA	864	-262
RAP1B	1058	-1031
RAPGEF1	-3458	1868
RBX1	1368	-3241
RELA	-542	2085
RORA	-4672	2287
RPLP0	-320	-185
RPS27A	-2201	-2138
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA5	-4445	-514
S1PR1	-3180	2436
SHC1	1472	-2954
SIGIRR	-3958	290
SKP1	1536	-2290
SMAD3	-4538	-4628
SMARCA4	1758	2317
SNRPA1	-3561	-3336
SOCS1	1375	-2999
SOCS2	-757	378
SOCS3	4399	2178
SOCS5	1047	-4583
SOD1	-1475	-1019
SOD2	1587	573
SOS1	-1748	-6775
SOS2	3740	-4105
SQSTM1	1438	-952
STAT1	-4529	2195
STAT2	-3894	-3295
STAT3	3628	-3606
STAT4	-4875	-425
STAT5A	2943	-6427
STAT5B	2923	-3446
STAT6	2340	-3911
STX1A	-1213	-2461
STX3	3861	-1755
STX4	189	-6001
STXBP2	4170	-6352
SYK	4192	-5054
TAB2	2942	1892
TALDO1	4392	-5245
TBK1	1067	-4616
TCP1	1254	2168
TEC	3276	-5839
TGFB1	1959	-6
TNF	-2348	-3779
TNFRSF1A	4299	-4958
TNFRSF1B	2421	2416
TNIP2	2166	-5726
TOLLIP	3905	-5037
TP53	-4034	-739
TRAF6	-80	-6118
TXLNA	-556	-78
TYK2	3021	-3105
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2N	607	1127
UBE2V1	2209	-1021
VAMP2	-4559	-2770
VAV1	3499	-3184
VEGFA	3235	-2723
VIM	4364	-2247
VRK3	396	-1398
YES1	-4772	-4415
YWHAZ	2200	541
ZEB1	-2414	-1406

---

---

Metabolism of proteins

Metabolism of proteins

metric	value
setSize	1263
pMANOVA	1.63e-11
p.adjustMANOVA	1.81e-09
s.dist	0.118
s.RNA	0.099
s.meth	0.0645
p.RNA	1.41e-08
p.meth	0.000224

Top 20 genes

Gene	RNA	meth
FURIN	4191	2351
MSRB1	4283	2285
SOCS3	4399	2178
SIAH2	3910	2185
GNG5	4043	1920
PHC2	4171	1830
KDELR1	4226	1780
CTSD	4381	1642
RNF146	3975	1789
MSRA	3186	2208
FKBP8	3911	1784
TMED7	3534	1939
RNF123	2846	2363
CCT5	3101	2091
CUL3	2861	2054
NOD2	3833	1528
PPP6C	2859	2020
TUBB4B	3111	1856
DAD1	2346	2452
GLB1	3992	1368

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
AARS2	-4585	-3118
ACTB	4156	-4515
ACTL6A	-2416	-4851
ACTR10	3309	-1291
ACTR1A	2965	-1
ACTR5	-4212	-3829
ACTR8	-1483	-5628
ADAM10	4030	976
ADAMTS10	-4118	-5260
ADAMTS13	-1309	958
ADAMTS17	-1134	463
ADAMTS6	-2253	1076
ADAMTSL4	3263	1378
ADAMTSL5	-2776	-6404
ADD1	2243	-89
ADORA2A	1094	-5935
ADRB2	-4624	-3531
ADRM1	1378	589
AGBL2	-3181	-5272
AGBL3	-3255	-646
AGBL5	1195	-3128
AGTPBP1	3757	-1941
AIMP2	-318	-4973
ALG10	-2662	-346
ALG10B	-2740	966
ALG11	-1067	-549
ALG12	849	-1300
ALG14	2265	1103
ALG2	-391	-625
ALG3	-392	-2680
ALG5	-228	-2175
ALG6	513	-4449
ALG8	-1083	-3591
ALG9	-3428	-1148
AMDHD2	-3859	539
AMFR	3176	-6742
ANK1	4018	-4221
ANK3	-1491	-6563
ANKRD28	-1940	-5108
ANKRD9	3621	-635
ANO8	2454	384
AP3M1	2123	-808
APC	1073	-4775
APEH	314	1724
APH1A	1453	-6066
APH1B	2555	2056
APLP2	4343	-3465
APP	4249	-5300
ARCN1	2180	-1676
ARF1	4184	-6686
ARF3	3396	-1912
ARF4	4256	-3280
ARF5	3493	-4789
ARFGAP1	-582	1688
ARFGAP3	1282	-5386
ARFGEF2	-1267	-5016
ARL2	-183	-4526
ARRB1	632	-6363
ARRB2	3860	-2243
ARSA	1183	-3099
ARSB	3290	-5722
ARSG	-1448	152
ARSK	-4182	-54
ASB1	1105	1900
ASB13	1106	-5265
ASB2	-4671	-2230
ASB6	-832	-6098
ASB7	2524	-4653
ASB8	1819	998
ASNS	-2775	12
ASXL1	-3718	-4360
ASXL2	580	-1790
ATF3	-3386	-4121
ATF4	2535	-956
ATF6	3846	-4952
ATP6V0D1	4282	-1003
ATXN3	495	1703
ATXN7	-599	759
AURKA	1109	-385
AURKAIP1	2437	-3441
AURKB	269	-889
AXIN1	-3703	-5655
AXIN2	-2699	-4719
B2M	-2195	-2389
B3GALNT2	-14	-1560
B3GNT2	2332	-1684
B3GNT7	-4854	-6593
B3GNT8	4117	-6681
B3GNTL1	2148	-2656
B4GALT1	1540	-160
B4GALT2	-1862	1307
B4GALT3	-3962	-4680
B4GALT4	121	-1422
B4GALT5	4052	52
B4GALT6	-2986	-6484
B4GAT1	-1725	451
BABAM1	-296	-1937
BAP1	352	1999
BARD1	-1019	-2910
BCL10	2320	-3261
BECN1	2690	459
BET1	-192	-4482
BET1L	-2389	332
BIRC2	1737	-1862
BIRC3	-4159	-2320
BIRC5	1291	-84
BLM	-1418	-2909
BMI1	-3460	-6383
BRCA1	2542	-4609
BTBD1	715	-5321
BTBD6	-1584	-136
BTRC	-1493	-2427
C1GALT1	-1285	-3509
CALM1	-626	-5019
CALR	2586	-3753
CALU	3497	1252
CAND1	-2041	-421
CANX	2151	-4839
CAPZA1	3648	572
CAPZA2	3920	-36
CAPZB	3576	-4065
CARS2	3080	-1826
CASP8AP2	-3688	231
CBX4	699	-5288
CBX8	2112	2207
CCDC59	-1161	-1734
CCNA2	520	-1132
CCNE1	-4514	-3403
CCNE2	1953	-3396
CCNF	-3202	-4258
CCT2	-3002	-727
CCT3	-719	-3438
CCT5	3101	2091
CCT6A	-210	1098
CCT7	-931	243
CCT8	2708	-1245
CD55	4229	-3923
CD59	2326	-6024
CDC20	1401	116
CDC25A	938	-1711
CDC34	3927	-2454
CDC73	1891	-2092
CDCA8	-553	472
CDK1	472	-4215
CDKN2A	-1595	-4511
CEBPB	3564	-5089
CEBPG	2122	1702
CHCHD1	3053	757
CHD3	-3413	422
CHST10	-4598	-5927
CISH	1836	1748
CKAP4	4355	-6717
CLSPN	1244	-1524
CMAS	4057	-2712
CNIH1	3425	-6699
COG1	-4760	-3663
COG2	-2597	-6132
COG3	-1652	-5701
COG4	-3	-984
COG5	-970	-1864
COG6	-1787	-358
COG7	1526	-4196
COG8	-118	1846
COMMD1	2334	-4720
COMMD10	1528	171
COMMD2	1054	782
COMMD3	-426	-6772
COMMD4	-1391	-5750
COMMD5	2137	-1140
COMMD6	-334	-2702
COMMD7	1997	2040
COMMD8	3171	187
COMMD9	3544	-4811
COPA	3780	1056
COPB1	3154	-1329
COPB2	3503	-1501
COPE	2906	213
COPS2	2476	896
COPS3	2403	-2950
COPS4	549	-3507
COPS5	1573	-1617
COPS6	508	-866
COPS7A	2731	-565
COPS7B	-3432	538
COPS8	-2966	-4126
COPZ1	1422	-5051
COPZ2	-4019	1305
CPM	2992	-4667
CREB3	-1269	-1896
CREB3L2	-361	-4035
CREB3L4	-3419	-6715
CREBBP	1153	-5804
CREBRF	-66	1873
CSF1	-622	-5924
CSNK1D	760	-1777
CSNK2A2	2614	-4422
CSNK2B	1389	-998
CTBP1	-2010	2394
CTDSP2	2183	-5429
CTNNB1	2626	-1691
CTR9	1117	-5535
CTSA	4412	-4847
CTSC	739	1561
CTSD	4381	1642
CTSZ	4137	-6765
CUL1	-4281	-5146
CUL2	805	-1212
CUL3	2861	2054
CUL4A	-1459	1876
CUL5	265	-3077
CUL7	-995	-2524
CUL9	-1888	-5978
CXXC1	-653	-2019
CYLD	-3240	1406
DAD1	2346	2452
DAG1	-2376	-146
DAP3	-402	-5114
DARS2	-1066	-124
DAXX	-3855	-450
DCAF10	1841	1341
DCAF11	-729	-1493
DCAF13	-1698	-2001
DCAF16	-4522	-4367
DCAF17	-4304	986
DCAF4	-4265	1739
DCAF5	-3380	-3273
DCAF6	3762	-2743
DCAF7	-523	683
DCAF8	-3484	-439
DCP2	2848	-2783
DCTN2	4235	-6011
DCTN3	2396	-4272
DCTN4	3796	-2073
DCTN5	-1222	-5100
DCTN6	3145	819
DCUN1D2	-1460	318
DCUN1D3	1560	-429
DCUN1D4	-3553	-2024
DCUN1D5	274	-5390
DDA1	1025	606
DDB2	-4408	-561
DDIT3	1831	-3177
DDX11	-1928	-280
DDX17	-1953	206
DDX5	-3465	1288
DDX58	-4651	-1002
DERL1	-3060	123
DERL2	987	-2287
DHDDS	-673	-4895
DHPS	166	-149
DIS3	-1292	-762
DNAJB11	2237	-137
DNAJC24	-3956	1293
DNAJC3	3828	-2353
DNMT1	-4835	1294
DNMT3A	-911	-6002
DNMT3B	1541	1185
DOHH	-506	-1316
DOLK	-1085	-2245
DOLPP1	919	-914
DPAGT1	678	650
DPH1	-4289	-3723
DPH2	-4099	-486
DPH3	3458	-3670
DPH5	93	1156
DPH7	-3975	-5720
DPM1	482	-2366
DPM2	1751	-1939
DPM3	823	-2637
DPP4	-2277	1454
DTL	131	-5529
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNLL1	2378	-3319
DYNLL2	-1189	214
EARS2	-4723	432
EDEM1	-36	1523
EDEM2	3982	-3093
EEF1A1	-1549	720
EEF1B2	-1271	1717
EEF1D	-268	-885
EEF1E1	-624	-1336
EEF1G	-431	-5880
EEF2	90	2127
EEF2KMT	-3471	2078
EID3	-4615	-328
EIF2AK3	-4250	-4333
EIF2B1	-139	-1150
EIF2B2	1080	-5304
EIF2B3	-2731	-2801
EIF2B4	862	-2442
EIF2B5	-3448	-1231
EIF2S1	1532	-4266
EIF2S2	2500	-783
EIF3A	676	1105
EIF3B	-2661	-1701
EIF3E	598	-2682
EIF3F	310	-169
EIF3G	281	1494
EIF3H	1755	1594
EIF3I	1740	-4154
EIF3J	597	-1483
EIF3K	456	1339
EIF3L	824	-4732
EIF3M	1681	887
EIF4A1	3303	-3762
EIF4A2	-4175	836
EIF4B	387	-4336
EIF4E	1789	1536
EIF4EBP1	2435	150
EIF4G1	3585	746
EIF4H	3412	-6751
EIF5	681	-1907
EIF5A	174	-363
EIF5B	-1399	705
ENGASE	-2450	-5741
EP300	2471	-4509
EPAS1	3494	535
ERAL1	-1394	-1779
ERCC8	1035	-5536
ERN1	-3305	2194
ERO1A	4115	-4535
ERO1B	-3996	-6067
ETF1	3209	758
ETFB	3368	-3921
EXOC1	2225	-2298
EXOC2	-2533	1713
EXOC3	1752	-3415
EXOC4	2187	-3655
EXOC5	1459	1408
EXOC6	4012	-5526
EXOC7	1842	-4686
EXOC8	-1	2121
EXOSC1	-319	-290
EXOSC2	-4132	1269
EXOSC3	161	-2555
EXOSC4	3305	-4410
EXOSC5	-1377	1591
EXOSC6	-3464	545
EXOSC7	-3889	-4665
EXOSC8	-4363	1020
EXTL2	-4160	-4800
EXTL3	2171	-922
FARS2	-3019	2295
FARSA	588	-5635
FARSB	-2763	1228
FAU	-124	-3862
FBXL12	-407	292
FBXL14	-1899	2358
FBXL15	1641	-4502
FBXL16	-2077	-4011
FBXL18	1098	-5248
FBXL19	3931	-6239
FBXL20	1804	-993
FBXL22	-3179	562
FBXL3	318	-4101
FBXL4	2136	-5130
FBXL5	4370	-6189
FBXL8	1413	-479
FBXO11	2793	-500
FBXO15	-394	647
FBXO21	-3979	-933
FBXO22	-1105	1132
FBXO30	1733	-609
FBXO31	-4652	480
FBXO32	-3875	-1875
FBXO4	-4600	-4056
FBXO6	-687	234
FBXO7	3250	-3059
FBXO9	4374	-3674
FBXW11	2510	-6747
FBXW2	2712	-3711
FBXW4	-4543	1993
FBXW5	76	-194
FBXW7	-2055	-5428
FBXW8	-3557	-2504
FEM1A	612	-82
FEM1B	1610	1880
FKBP14	-2911	1330
FKBP8	3911	1784
FN3KRP	-4213	1195
FOXK1	-1539	-5199
FOXK2	1123	-6253
FPGT	3127	-2826
FSTL3	4310	88
FUCA1	3203	-5579
FUCA2	3743	-427
FUOM	-1578	-5803
FURIN	4191	2351
FUT8	-3421	-2455
GADD45GIP1	523	-3607
GALNT10	-997	-6074
GALNT11	-942	-3318
GALNT12	-3477	-5876
GALNT2	4061	-5164
GALNT3	557	-2941
GALNT4	3012	-180
GALNT6	-263	-6156
GALNT7	3699	57
GAN	-440	-2479
GANAB	-317	-3501
GATA3	-4799	1861
GBA	4133	-5623
GBF1	-1279	-120
GCNT1	3791	179
GFM1	-1613	-2991
GFM2	1354	-5140
GFPT1	-2014	-2828
GGA1	731	-3812
GGA2	-2051	-3081
GGA3	1326	450
GGCX	2003	-3236
GLB1	3992	1368
GMDS	1849	-1375
GMPPA	1347	-4201
GMPPB	-2358	1238
GNA15	4391	-6690
GNAQ	4145	-6733
GNB1	3736	-2920
GNB2	3650	-309
GNB4	3163	-6007
GNB5	163	1821
GNE	-1580	-4921
GNG2	-2538	-3847
GNG3	285	2231
GNG4	-649	2073
GNG5	4043	1920
GNG7	-1581	-4773
GNGT2	-4735	2438
GNPNAT1	-3379	-2849
GOLGA2	2513	1847
GOLGB1	-1635	-3196
GOLM1	-2162	-6094
GORASP1	2742	-2178
GOSR1	-61	-3152
GOSR2	-454	1643
GPAA1	2395	-843
GPS1	-1352	-6247
GSK3A	3415	-2192
GSPT1	2672	-4456
HARS2	-2503	-2407
HDAC1	184	-1016
HDAC2	2129	-46
HDAC3	1727	-3771
HDAC4	4126	-3817
HDAC7	2465	-4900
HDGF	3126	-3978
HERPUD1	3014	-1806
HGS	1647	2123
HIF1A	3219	-3349
HIPK2	2441	-1520
HLA-A	-771	-5991
HLA-B	205	1015
HNRNPC	2536	-1112
HNRNPK	3259	-2386
HSP90B1	647	-1371
HYOU1	-35	-3315
IARS2	2304	-844
ICMT	-252	-71
IDE	2996	-777
IFIH1	-4282	-4856
IGFBP4	-2464	-6569
IGFBP6	674	-6762
IKBKE	1750	2086
INCENP	-1832	-2850
ING2	1603	-2115
INO80	-2950	-74
INO80B	-588	-3700
INO80C	2537	-3246
INO80D	-1594	-869
INO80E	-2619	-2832
ITM2B	2390	-3556
JOSD1	64	-3051
JOSD2	3524	-957
KAT2A	-3970	-5050
KAT2B	-722	-1588
KBTBD6	870	327
KBTBD7	2608	-1326
KBTBD8	-1262	-4094
KCTD6	1579	886
KCTD7	-4415	-602
KDELR1	4226	1780
KDELR2	3393	-2980
KDM1B	1918	1468
KEAP1	1826	-2872
KHSRP	866	-5005
KIF5B	3711	-3520
KIN	1197	617
KLHDC3	1588	2058
KLHL11	-1956	186
KLHL2	4247	-4276
KLHL20	-4381	-2781
KLHL21	1909	-1243
KLHL22	-4331	-899
KLHL25	-3912	-464
KLHL5	1936	-4208
KTN1	1126	-2404
L3MBTL2	-3969	-4114
LAMB2	156	-2207
LARS2	-2869	-1472
LEO1	10	791
LGALS1	4168	-79
LMAN1	-3888	596
LMAN2	3016	-2497
LMAN2L	2928	-1590
LMNA	1348	-6474
LMO7	-3402	2419
LONP2	-1766	372
LRR1	-2482	1362
LRRC41	3257	404
LTBP1	3541	-4651
LYPD3	-2349	-4231
MAN1A1	3520	-447
MAN1A2	-619	-1465
MAN1B1	-1477	2249
MAN1C1	-2148	-1205
MAN2A1	-418	-4486
MAN2A2	2751	-5172
MANEA	-226	172
MAP3K7	761	-2089
MARS2	-4358	-2209
MAT2B	-3753	-2153
MAVS	3048	-4500
MBD1	639	-1177
MBD5	831	-6395
MBD6	3323	-5542
MBTPS1	955	-398
MCFD2	3031	-158
MCRS1	-2750	1266
MDC1	-4716	-902
MDM2	1551	-1318
MDM4	-385	-2440
MEN1	-2877	-2311
METTL21A	1191	1437
METTL22	1960	2176
MFGE8	1205	-527
MGAT1	2546	1169
MGAT2	507	-1666
MGAT4A	-1741	-2254
MGAT4B	3961	-6439
MGAT5	-918	-5572
MIA3	-1938	-3428
MLEC	737	953
MOGS	-913	-2356
MPDU1	3413	-1260
MPI	-3963	-5890
MRPL1	-1739	786
MRPL10	-2754	-6144
MRPL11	-1179	-4005
MRPL12	806	-4827
MRPL13	1022	-1113
MRPL14	-793	-5202
MRPL15	431	1654
MRPL16	643	-5949
MRPL18	675	-1383
MRPL19	141	-3772
MRPL2	-2337	-3200
MRPL20	-137	1926
MRPL21	259	-3387
MRPL22	546	-3797
MRPL23	2962	-2397
MRPL24	-1961	-3055
MRPL27	-919	-509
MRPL30	2058	-2103
MRPL32	-3125	-1085
MRPL33	2960	-4150
MRPL34	-322	-590
MRPL35	-1384	84
MRPL36	641	-3325
MRPL37	1059	-5276
MRPL38	-2054	-5235
MRPL39	-3811	-569
MRPL4	-568	-978
MRPL41	-415	-991
MRPL42	-2413	-66
MRPL43	-749	-795
MRPL44	1666	-5339
MRPL45	874	2443
MRPL46	-3033	-3823
MRPL47	1437	-580
MRPL48	-831	674
MRPL49	-3349	-2018
MRPL50	-2876	-1736
MRPL51	1805	-831
MRPL52	1279	-1650
MRPL53	2385	-1402
MRPL54	-592	-1702
MRPL55	-1816	-2067
MRPL57	-479	-2446
MRPL9	-3954	-6623
MRPS10	1788	-935
MRPS11	427	-697
MRPS12	-1078	162
MRPS14	-1505	-2698
MRPS15	459	-5176
MRPS16	1624	-1310
MRPS17	-1709	-3243
MRPS18A	235	-5497
MRPS18B	-3898	1727
MRPS18C	51	-2170
MRPS2	-2164	-5148
MRPS21	-2951	-3126
MRPS22	555	-4788
MRPS23	524	-5899
MRPS24	890	-1344
MRPS25	-3519	-2529
MRPS26	-1936	-3032
MRPS27	-3081	629
MRPS28	449	-928
MRPS30	-2827	-4051
MRPS31	-1496	-157
MRPS33	-3285	-276
MRPS34	1328	-1631
MRPS35	901	-1521
MRPS36	3096	-1198
MRPS5	1810	-1972
MRPS6	-4092	-3712
MRPS7	882	204
MRPS9	-4148	-5197
MSRA	3186	2208
MSRB1	4283	2285
MSRB2	4185	-5138
MTFMT	1171	-1706
MTIF2	-266	-3124
MTIF3	900	-4313
MTRF1L	1956	212
MUC1	2718	-5557
MUC12	-3930	-5807
MUC5B	-1389	2353
MUL1	954	-3003
MVD	-1805	1954
MYSM1	-2379	-616
N6AMT1	-4268	1363
NAE1	-4057	897
NAGK	1038	-5552
NANP	-3279	-585
NANS	3538	529
NAPA	438	-4125
NAPB	-838	471
NAPG	1458	-97
NAPSA	-1251	-5003
NARS2	-3200	-2538
NCOA2	343	1407
NCOR2	3557	-4281
NCSTN	4254	-3821
NDC1	-4789	-5228
NEDD8	2677	-1600
NEGR1	446	-6424
NEU1	4167	-3878
NEU3	-1138	-1409
NEURL2	-930	2421
NFKB2	-367	388
NFKBIA	2851	1159
NFRKB	-868	-3238
NFYA	1189	1464
NFYB	-3536	-531
NFYC	3345	-3078
NGLY1	-1096	-236
NICN1	-550	-2869
NLRP3	4089	-6357
NOD1	-4837	-5170
NOD2	3833	1528
NOP56	-4540	-523
NOP58	-3529	-2406
NPL	4408	-6573
NR1H2	3207	-1471
NR1H3	-1069	-2305
NR1I2	-1321	-4903
NR2C1	-3506	-1463
NR3C1	162	-2420
NR3C2	-3885	324
NR4A2	-490	1416
NSMCE1	2425	2210
NSMCE2	2329	-6425
NSMCE4A	-4195	-4495
NTNG2	2189	903
NUB1	-4677	1450
NUCB1	4079	-5498
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
NUS1	3476	-9
OS9	4087	-975
OTUB1	430	-5956
OTUD3	-3966	-1582
OTUD7B	-4742	-2644
OTULIN	-219	1535
OXA1L	2179	-3864
P2RY2	2384	-5187
P4HB	3831	-1549
PABPC1	2061	-2769
PAF1	1180	-5838
PARK7	2635	-821
PARN	-1591	-4138
PARP1	-4548	-5521
PARS2	-2071	-907
PCMT1	4023	-1554
PCNA	-1833	-511
PDCL	-410	-1308
PDIA3	1451	1466
PDIA5	3297	-5942
PDIA6	2339	1837
PEX10	-2043	1348
PEX12	-2965	-2164
PEX13	178	-1839
PEX14	1024	-3892
PEX2	948	-5892
PEX5	1502	-6491
PFDN1	1230	-1084
PFDN2	342	-3571
PFDN4	365	-3065
PFDN5	1257	-5178
PGAP1	-2987	-660
PGM3	-297	1964
PHC1	-2820	-5180
PHC2	4171	1830
PHC3	-2698	1805
PIAS1	3175	-2534
PIAS2	-2430	-2314
PIAS3	-422	1855
PIAS4	1971	-3982
PIGC	-455	-2121
PIGF	2736	-1570
PIGH	-3275	-1358
PIGK	-1847	-2040
PIGL	-4517	-1793
PIGM	16	-4141
PIGN	575	-3172
PIGO	-2995	-2601
PIGP	-1572	-3043
PIGQ	553	-2760
PIGS	2984	-749
PIGT	306	-1299
PIGU	-3173	-504
PIGV	-545	-2037
PIGW	-4526	1896
PIGX	2084	-5421
PLAUR	3822	-6237
PML	-2938	549
PMM1	1483	-1060
PMM2	428	-2687
PNPLA2	4111	-5698
POFUT2	-3868	1983
POLB	-2444	-1516
POM121	-2766	-1787
POM121C	-2305	-4315
POMGNT1	-4644	-826
POMGNT2	-1230	-6177
POMK	-577	-1346
POMT1	-2925	1390
POMT2	193	-669
PPA1	606	1448
PPA2	661	-5450
PPP2R5B	2831	-6343
PPP6C	2859	2020
PPP6R1	2015	-1276
PPP6R3	1081	-3726
PRKCSH	1991	-3007
PRKDC	-3668	1316
PRMT3	522	-372
PSENEN	2260	-3620
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTCD3	-3795	-1512
PTEN	3844	-1100
PTP4A2	820	2110
PTRH2	1691	-4375
PUM2	-604	-801
QSOX1	4315	-1087
RAB10	4103	-3437
RAB11A	3969	-2965
RAB11B	1596	-387
RAB12	-284	-1635
RAB14	3027	1334
RAB18	3438	-1995
RAB19	1545	-3370
RAB1A	4176	-1703
RAB1B	3749	-264
RAB22A	-1258	-3947
RAB23	331	-2847
RAB24	2063	-3725
RAB26	-1325	2425
RAB27A	3811	-1181
RAB29	-3648	282
RAB2A	3923	-2810
RAB2B	-3071	-557
RAB30	-3466	-2803
RAB33B	3130	547
RAB34	3819	-3968
RAB35	1394	780
RAB37	-4565	-5384
RAB3A	3646	-1080
RAB3D	4263	-6515
RAB40B	-4312	1177
RAB40C	3694	8
RAB43	2645	1154
RAB4A	3532	-5479
RAB4B	1028	1318
RAB5A	3035	-1686
RAB5B	2790	-2055
RAB5C	3953	-1152
RAB6A	3657	-311
RAB7A	4002	-5570
RAB8A	1346	-1289
RAB8B	2696	79
RABGGTA	-734	1696
RABGGTB	-1597	2306
RAD18	-4637	812
RAD21	527	702
RAD23A	2689	-3621
RAD23B	4081	-3906
RAD52	-327	-2399
RAE1	1963	-39
RANBP2	-273	-4704
RANGAP1	-4525	1644
RARA	2642	-5249
RARS2	-253	-1305
RBBP5	328	-779
RBX1	1368	-3241
RCE1	-1412	-282
RCN1	-3967	-2128
RECK	-2791	-4325
RELA	-542	2085
RFT1	1549	147
RHOA	3753	1313
RHOT1	4352	-5271
RING1	-1216	-1490
RNF103	-1360	-2036
RNF123	2846	2363
RNF135	3897	-6458
RNF139	842	354
RNF146	3975	1789
RNF152	1085	-1925
RNF168	-1297	1626
RNF181	2412	312
RNF185	2681	-2775
RNF2	1192	-1936
RNF20	2258	-799
RNF40	2752	-5137
RNF5	-1999	-4625
RNF7	3510	-1943
RORA	-4672	2287
RPA1	-4688	-2495
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPN1	3580	-2841
RPN2	3058	-688
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
RRAGA	2539	-1657
RTF1	1201	-4613
RTN4RL2	2907	-6031
RUVBL1	-2905	256
RWDD3	-82	-4374
SAE1	-2761	2410
SAFB	838	-3542
SAR1B	2676	489
SARS2	-3854	465
SATB1	-2592	-1979
SATB2	2834	-6456
SCMH1	-1799	1397
SEC11A	3516	-4081
SEC11C	-3084	-4262
SEC13	2266	-3749
SEC16A	1697	-1722
SEC22A	-1537	696
SEC22C	-1264	1879
SEC23A	3162	-5141
SEC23IP	-154	-38
SEC24A	3350	61
SEC24B	1233	-5505
SEC24C	-768	805
SEC24D	3637	-3966
SEC31A	346	-4985
SEC61A1	2654	-592
SEC61A2	-3985	917
SEC61B	2971	33
SEC61G	1745	1052
SEH1L	-1875	-1615
SEL1L	2877	-2307
SENP1	-2622	-1254
SENP2	1418	-382
SENP5	-2097	261
SENP8	1005	-1816
SERP1	3891	520
SHC1	1472	-2954
SHISA5	393	1884
SHPRH	-2810	-353
SIAH1	-897	-6217
SIAH2	3910	2185
SIN3A	-3818	-4151
SKIV2L	-1017	-2116
SKP1	1536	-2290
SKP2	-2759	-1566
SLC17A5	1875	-3631
SLC30A5	-733	-2119
SLC30A6	-2	-1069
SLC30A7	-1328	-2297
SLC35A1	3104	-4021
SLC35C1	880	-5366
SMAD1	3872	-3272
SMAD2	1830	-1994
SMAD3	-4538	-4628
SMAD4	-2796	-6535
SMAD7	-4617	-4450
SMC3	-596	-1642
SMC5	-2264	-2372
SMC6	-1275	1981
SMURF2	-3735	-3048
SOCS2	-757	378
SOCS3	4399	2178
SOCS5	1047	-4583
SORL1	2697	-5169
SP100	1552	-769
SP3	2133	-3116
SPCS2	1060	2136
SPCS3	1578	437
SPON2	-4842	1081
SPSB1	756	-3865
SPSB3	-1858	-4699
SPTAN1	-4344	-1250
SPTBN1	-2529	-3924
SPTBN5	-1052	2344
SRD5A3	1390	442
SRP14	2573	-848
SRP19	1533	-1180
SRP54	2732	-116
SRP68	635	1885
SRP72	-468	-2605
SRPRB	-3260	59
SSR1	2729	879
SSR2	911	-1242
SSR3	2368	-4032
ST3GAL1	-2406	1767
ST3GAL2	3958	-2686
ST3GAL3	158	-1055
ST3GAL4	2285	-4996
ST3GAL5	-4428	1507
ST3GAL6	2794	-5427
ST6GAL1	-4715	1948
ST6GALNAC3	4221	145
ST6GALNAC4	-207	-5981
ST6GALNAC6	-4734	2144
ST8SIA1	-2612	-2246
ST8SIA4	3708	-3013
STAG1	-1977	-863
STAM	397	770
STAM2	2488	-2181
STAMBP	498	-93
STAMBPL1	-3882	-5600
STAT3	3628	-3606
STT3A	1442	-4222
STX17	-4100	-4247
STX1A	-1213	-2461
STX5	3071	-1823
SUDS3	1652	-1851
SUMF1	4144	-5376
SUMF2	-4706	-3692
SUMO1	2903	-3986
SUMO3	2991	-5577
SVBP	3085	-4594
SYVN1	313	-5153
TAF10	3039	1606
TARS2	-4491	-1091
TATDN2	-3241	2494
TBC1D20	-8	-5205
TBCA	2002	-1541
TBCB	889	-442
TBCC	-3580	-4485
TBCD	-3280	2325
TBCE	-996	-5873
TCF7L2	-1917	-3431
TCP1	1254	2168
TDG	2782	621
TFPT	2035	-333
TGFA	4083	-3020
TGFB1	1959	-6
TGFBR1	486	-6163
TGFBR2	1359	-5224
TGOLN2	3988	-2836
THRA	-1986	-2798
TLN1	3876	191
TMED10	94	604
TMED2	2424	-3656
TMED3	868	-2936
TMED7	3534	1939
TMED9	3072	-1992
TMEM115	2141	-703
TMEM129	1383	1624
TNFAIP3	-4067	-785
TNIP1	3790	-2256
TNIP2	2166	-5726
TNKS	-2959	-1583
TNKS2	-161	-449
TOMM20	-824	2451
TOP1	3338	-2610
TOP2A	891	192
TOP2B	-819	-3244
TOPORS	915	462
TP53	-4034	-739
TP53BP1	-4095	-2967
TPGS1	1616	1697
TPGS2	-947	-4475
TPP1	4108	237
TPR	-2242	-973
TPST1	4286	-2233
TPST2	2256	-2387
TRAF2	-4539	-1442
TRAF3	-1701	2379
TRAF6	-80	-6118
TRAM1	-1398	-1688
TRAPPC1	3441	-3029
TRAPPC10	-3243	2388
TRAPPC2L	-686	1441
TRAPPC3	3041	-2853
TRAPPC4	-2106	-3231
TRAPPC5	1974	-5629
TRAPPC6A	-4050	1765
TRAPPC6B	1463	-662
TRAPPC9	2048	-4354
TRIM13	-675	497
TRIM25	3700	-3718
TRIM27	3651	-1744
TRIM28	-1538	1191
TRMT112	233	-4666
TRRAP	-2111	1860
TSFM	439	100
TSPAN14	2946	1366
TSPAN33	2497	-5908
TSPAN5	325	-6310
TTF1	-112	-4199
TTL	-1235	-4334
TTLL1	-2474	-5225
TTLL11	-1603	-5747
TTLL12	2062	1569
TTLL3	-699	-2560
TTLL4	3502	-4814
TTLL5	-1231	-3569
TTLL7	2551	-1018
TUBA1A	3150	-4767
TUBA1B	2142	-1058
TUBA1C	3089	-150
TUBA4A	2678	-4571
TUBA4B	618	-5863
TUBB2A	3956	-4771
TUBB4B	3111	1856
TUFM	1639	-69
TXN	3732	284
UAP1	-4784	-3110
UBA2	-2022	1399
UBA3	3420	-2122
UBA52	349	752
UBA6	1163	1251
UBB	2759	-1321
UBC	1618	-2568
UBE2B	2966	-2486
UBE2C	1933	1091
UBE2D1	4255	-1581
UBE2D2	1717	-3799
UBE2D3	3944	-373
UBE2E1	2822	-5882
UBE2E3	1883	-5759
UBE2F	3165	-3774
UBE2G1	1840	-1626
UBE2G2	-2650	-3560
UBE2H	3352	-1867
UBE2I	-245	233
UBE2J2	3722	-368
UBE2K	2901	1379
UBE2L3	3281	-3496
UBE2L6	-4256	-4206
UBE2M	3239	-3585
UBE2N	607	1127
UBE2Q2	-4419	-4146
UBE2R2	3894	-3277
UBE2S	1766	2449
UBE2T	-2946	-2989
UBE2V2	934	-3487
UBE2W	3522	-618
UBE2Z	-4046	-4538
UBXN1	595	-2222
UBXN7	481	-1320
UCHL3	616	-752
UCHL5	-2570	-6243
UGGT1	1923	-3498
UHRF2	-3522	-1716
UIMC1	4261	-3114
USO1	1467	1196
USP10	3272	-5328
USP12	1868	-4528
USP13	-2120	-667
USP14	-1600	-5011
USP15	2481	686
USP16	-2598	1533
USP18	-4814	-2616
USP19	-150	492
USP20	-4386	2238
USP21	-2215	-3841
USP22	2770	-3087
USP24	-4261	1979
USP25	48	1721
USP28	-4863	-3970
USP3	3978	-267
USP30	271	-2625
USP33	-274	-5582
USP34	-310	-4481
USP4	3446	-5610
USP42	-4306	-3364
USP44	-2526	-4859
USP47	-1181	-3304
USP48	1593	-4606
USP49	837	1872
USP5	-1874	-173
USP7	2576	-2216
USP8	2632	-424
VAMP2	-4559	-2770
VARS2	-1894	-5297
VASH1	420	1394
VCP	2902	-2411
VCPIP1	-90	-476
VCPKMT	99	-631
VDAC1	1566	-3624
VDAC3	134	1058
VDR	3768	-3651
VHL	1262	1389
WAC	2018	53
WARS2	-1458	-764
WDR20	-331	-4288
WDR48	-4427	-5481
WDR5	39	-5613
WDR61	22	-4752
WDTC1	2833	-205
WFS1	-3431	409
WIPI1	3134	-1090
WRAP53	-3230	-3158
WRN	-4713	-2102
WSB1	3475	-637
WSB2	3405	-6513
XPC	-4359	-402
XRCC4	2821	-3706
XRN2	4366	-5589
YARS2	-1239	-3405
YIF1A	-77	-5708
YKT6	1980	-3331
YOD1	3265	-556
YY1	169	-5165
ZBTB16	215	2289
ZBTB17	542	-891
ZDHHC2	2010	-3322
ZNF131	-4251	-423

---

---

rRNA processing

rRNA processing

metric	value
setSize	159
pMANOVA	1.71e-11
p.adjustMANOVA	1.81e-09
s.dist	0.336
s.RNA	-0.289
s.meth	0.171
p.RNA	3.63e-10
p.meth	0.000207

Top 20 genes

Gene	RNA	meth
NOP14	-4022	2384
RRP9	-3589	2034
RPL3	-2885	2313
MTERF4	-4033	1559
RPL23A	-3334	1843
EXOSC2	-4132	1269
NOL9	-3670	1426
RPS11	-2332	2115
RPL13A	-2727	1802
EXOSC8	-4363	1020
SNU13	-2174	1961
RPL32	-2103	1928
RPP38	-2263	1598
WDR75	-3509	1028
NOC4L	-1668	1990
RPS2	-1344	2392
RPL35	-2671	952
RPL4	-1064	2321
RPS10	-1780	1246
EXOSC5	-1377	1591

Click HERE to show all gene set members

All member genes

	RNA	meth
BMS1	-4492	-2552
BYSL	-1331	-88
C1D	1194	510
CSNK1D	760	-1777
CSNK1E	-3709	-4750
DCAF13	-1698	-2001
DDX21	1018	760
DDX47	-4257	-3056
DDX49	1815	-4408
DDX52	142	-1954
DHX37	-2753	-312
DIS3	-1292	-762
EBNA1BP2	-1224	1600
ELAC2	-4545	-916
ERI1	2157	130
EXOSC1	-319	-290
EXOSC10	-4315	-1580
EXOSC2	-4132	1269
EXOSC3	161	-2555
EXOSC4	3305	-4410
EXOSC5	-1377	1591
EXOSC6	-3464	545
EXOSC7	-3889	-4665
EXOSC8	-4363	1020
FAU	-124	-3862
FBL	-3651	-2611
FCF1	1633	-2675
FTSJ3	-1200	-670
GAR1	-2203	-4416
GNL3	-2859	-1419
HEATR1	-3738	-1985
IMP3	-3288	99
IMP4	-4084	-2925
ISG20L2	1309	1893
KRR1	-2907	-6562
LTV1	-1284	-3205
MPHOSPH10	-2537	-57
MPHOSPH6	685	-5463
MRM1	-3829	-5990
MTERF4	-4033	1559
NCL	-3204	-2515
NHP2	-1038	-260
NIP7	-1813	-1760
NOB1	-3724	-1000
NOC4L	-1668	1990
NOL11	-3807	-2629
NOL12	1851	505
NOL6	-4043	526
NOL9	-3670	1426
NOP10	3759	-3526
NOP14	-4022	2384
NOP2	-3530	-2438
NOP56	-4540	-523
NOP58	-3529	-2406
NSUN4	-1451	-3469
PDCD11	-4401	-2174
PELP1	-4054	-1579
PES1	-609	-3908
PNO1	-2170	-5495
PWP2	-378	681
RBM28	-4493	-685
RCL1	-244	-1421
RIOK1	-1131	-2098
RIOK2	300	-954
RIOK3	4013	-2443
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPP14	974	-354
RPP21	-1631	-5256
RPP25	-2741	-5917
RPP30	-2675	-5522
RPP38	-2263	1598
RPP40	-1467	-1426
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
RRP1	-924	77
RRP7A	-846	-2961
RRP9	-3589	2034
SENP3	966	-1248
SNU13	-2174	1961
TBL3	-1027	994
TEX10	-3427	-1947
TFB1M	-4290	-3739
THUMPD1	-3443	-4292
TRMT112	233	-4666
TSR1	-3410	-3041
TSR3	1337	1167
UBA52	349	752
UTP15	-3872	-2796
UTP18	1940	-3819
UTP20	-3834	-1372
UTP3	-874	-3665
UTP6	-1347	-1904
WDR12	1988	706
WDR18	-691	-2042
WDR3	-2064	-5710
WDR36	-1177	-2277
WDR43	-2494	-4225
WDR75	-3509	1028
XRN2	4366	-5589

---

---

Metabolism

Metabolism

metric	value
setSize	1216
pMANOVA	3.16e-11
p.adjustMANOVA	3.06e-09
s.dist	0.124
s.RNA	0.123
s.meth	-0.0148
p.RNA	3.67e-12
p.meth	0.404

Top 20 genes

Gene	RNA	meth
GNA15	4391	-6690
GGT1	4376	-6607
ACSS2	4379	-6534
DSE	4401	-6498
TSPO	4344	-6553
PTGR1	4217	-6711
GLUL	4152	-6758
ARF1	4184	-6686
GNAQ	4145	-6733
TBXAS1	4073	-6709
ENO1	4084	-6654
PRKACA	4378	-6032
PLD1	4321	-6058
MGST2	3984	-6536
NUDT16	4101	-6171
ALOX5	4150	-6082
HYAL2	4198	-5951
COMT	3725	-6677
NT5C2	3930	-6291
SLC16A3	4026	-6120

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
AACS	105	843
AANAT	-18	-4522
ABCA1	2459	-6487
ABCC1	179	-871
ABCC5	794	-2379
ABCD4	-2830	-4648
ABHD10	-2035	-4844
ABHD14B	-3449	-1729
ABHD3	2932	-4046
ABHD4	2638	-5841
ABHD5	3512	-5560
ACAA1	3734	1410
ACACA	2039	-164
ACACB	-3532	-4884
ACAD10	1792	-83
ACAD11	-3656	-2327
ACADM	-404	-2163
ACADS	1543	-6188
ACADSB	-3777	-2708
ACAT1	2158	-2579
ACAT2	-1106	-2151
ACBD4	-1346	-2973
ACBD5	-398	-2520
ACBD6	-4143	-1414
ACBD7	1102	-5886
ACER2	654	-2800
ACER3	4240	-1641
ACLY	1961	-5417
ACOT13	2098	-3113
ACOT7	-981	1021
ACOT8	3578	-2563
ACOX1	4070	-5075
ACOX3	2397	-4725
ACOXL	1769	2527
ACP5	-578	-5814
ACP6	-1122	-5222
ACSF2	-4243	-5644
ACSF3	-119	-5695
ACSL1	4266	-1604
ACSL3	3461	-4285
ACSL5	-3830	-215
ACSL6	-1821	2501
ACSM1	-3321	-6655
ACSM3	-2384	-6252
ACSS1	-4719	-3949
ACSS2	4379	-6534
ACY1	-1382	-1933
ADA	-4853	1567
ADAL	-4220	-2064
ADCY4	2020	-6389
ADCY7	-980	-5596
ADCY9	33	-2618
ADH5	-2659	-946
ADHFE1	-1589	17
ADIPOR1	4361	-2029
ADIPOR2	1890	-3302
ADK	-693	-4448
ADO	-543	1444
ADPGK	2190	-1337
ADSL	1925	-43
AFMID	2354	-3146
AGK	-4757	-3004
AGL	-940	-3188
AGMAT	-1707	859
AGPAT1	3663	559
AGPAT2	4289	2250
AGPAT3	1787	-2039
AGPAT4	-2892	-4185
AGPAT5	-3512	221
AGPS	2135	-3742
AGRN	-4553	-2304
AHCY	146	-5043
AHCYL1	2658	-3553
AHR	3240	2099
AHRR	-1770	-702
AIMP2	-318	-4973
AIP	-1061	1761
AK2	768	-1881
AK9	73	-5789
AKR1A1	440	-4351
AKR1B1	-4638	1845
AKR7A2	821	-6736
AKT1	1234	-1942
ALAD	3874	-1369
ALDH18A1	-4149	-2831
ALDH1B1	-4027	-1808
ALDH3A2	264	-2186
ALDH4A1	4306	-4122
ALDH6A1	1385	-112
ALDH9A1	926	-1095
ALDOA	4285	-1349
ALDOC	-1028	-6226
ALOX5	4150	-6082
ALOX5AP	3490	-6710
AMACR	-2220	-663
AMD1	1231	-2184
AMDHD1	-667	-729
AMPD2	2095	-6207
AMPD3	3997	-5620
APRT	-834	-204
ARF1	4184	-6686
ARF3	3396	-1912
ARG2	2202	-3974
ARNT	3596	1140
ARNTL	-2150	-4129
ARSA	1183	-3099
ARSB	3290	-5722
ARSG	-1448	152
ARSK	-4182	-54
ARV1	-813	-2677
ASAH1	3880	335
ASL	2313	-4506
ASNS	-2775	12
ASRGL1	1878	-6497
ATIC	-4202	2083
AUH	-375	700
AZIN1	3045	1461
AZIN2	-4215	-6241
B3GALT4	2047	-394
B3GALT6	-1337	2030
B3GAT2	-625	-5068
B3GAT3	-879	646
B3GNT2	2332	-1684
B3GNT7	-4854	-6593
B4GALT1	1540	-160
B4GALT2	-1862	1307
B4GALT3	-3962	-4680
B4GALT4	121	-1422
B4GALT5	4052	52
B4GALT6	-2986	-6484
B4GALT7	-2369	482
B4GAT1	-1725	451
BCAT1	3547	-6102
BCAT2	-887	-482
BCKDHA	2450	-3682
BCKDHB	-4311	-3761
BCKDK	4155	-3369
BDH1	-3780	-5778
BDH2	-4379	-6434
BLVRA	2273	1170
BLVRB	4360	-5026
BPHL	-2944	-3139
BPNT1	-341	-1649
BRIP1	-4454	-2323
BSG	4245	-1562
BTD	-4787	146
CA13	382	-3867
CA6	-858	1612
CACNA1C	-4026	-4608
CACNA2D2	-4601	-64
CACNB3	111	-6297
CAD	-3424	1818
CALM1	-626	-5019
CARNMT1	-3940	2061
CARNS1	-3836	-5922
CAV1	619	-2432
CBR3	-2833	-6380
CBR4	-388	-2264
CCNC	589	-1138
CD320	-3400	103
CD38	-4665	-5254
CD44	3760	266
CDIPT	2525	-2467
CDK19	3319	-2575
CDK8	-594	-5509
CDS2	2711	979
CEPT1	353	289
CERK	-1598	1601
CERS5	-758	-6266
CERS6	2291	-3796
CES2	2587	-6637
CHAC2	-2161	-1353
CHD9	-1380	-5791
CHKA	2436	-4562
CHKB	-992	816
CHP1	4290	-4961
CHPF	-3765	1258
CHPF2	3439	-3165
CHPT1	4062	-5900
CHST11	1793	-4503
CHST12	-4893	761
CHST14	357	-6351
CHST2	-4217	1725
CHSY1	3638	-4487
CIAO1	-3543	-1918
CIAPIN1	-2585	-2503
CKB	-4724	-4979
CLOCK	-2411	-1159
CMBL	2647	-6545
CMPK1	-475	-3522
CNDP2	-1463	-1531
COA1	-4383	-5247
COASY	3359	-790
COMT	3725	-6677
COQ10A	-4329	-2921
COQ10B	1398	-2505
COQ2	3120	-5067
COQ3	-3283	-2779
COQ5	2207	-3083
COQ6	-4521	-1910
COQ7	1744	1971
COQ9	-2706	695
COX10	-1812	524
COX11	-4412	-789
COX14	-471	-3835
COX15	3619	522
COX16	34	-1160
COX19	-2178	-4047
COX20	-1527	-4841
COX4I1	1484	-5506
COX5A	2495	-2944
COX5B	2517	382
COX6A1	1930	-961
COX6B1	2224	-2634
COX6C	220	-1411
COX7A2L	3386	-2476
COX7C	176	-4071
COX8A	2745	-1258
CPNE1	-1012	1274
CPNE3	2335	-2088
CPOX	-209	1290
CPS1	-939	314
CPT1A	1921	-6398
CPT2	2700	-6494
CPTP	1249	-2096
CRAT	4098	-4890
CREBBP	1153	-5804
CRLS1	4211	-4654
CRYL1	1869	-4672
CRYM	3285	-1596
CS	1270	294
CSAD	3046	1962
CSGALNACT1	1444	2502
CSGALNACT2	3702	194
CSNK1G2	284	-1639
CSNK2A2	2614	-4422
CSNK2B	1389	-998
CTH	-2711	-475
CTPS1	-3623	1679
CTSA	4412	-4847
CYB5A	-1683	-4677
CYB5B	-4199	-2367
CYB5R3	4090	-1540
CYC1	990	464
CYCS	-411	-3927
CYP2R1	-3508	-1915
CYP2U1	-4687	-4531
CYP46A1	-188	1529
CYP4F22	-4840	-2371
CYP4V2	-3214	-4041
CYP51A1	2876	-5191
D2HGDH	-1768	-3476
DBI	2529	441
DBT	-1677	-4561
DCK	-2956	1411
DCTD	-3640	-1612
DCTPP1	-510	-3112
DCXR	-100	-2013
DDAH2	3531	-5633
DDHD1	-4459	1414
DDHD2	-4582	-2861
DECR1	2037	-528
DECR2	247	830
DEGS1	2496	-193
DERA	3866	-756
DGAT1	2033	-6115
DGAT2	4236	-1911
DGUOK	912	1248
DHCR24	858	-5657
DHCR7	2784	-3544
DHFR	1965	216
DHODH	-1720	-51
DHRS7B	3327	-3549
DHTKD1	2172	208
DLAT	-1050	-1484
DLD	3147	1320
DLST	-3036	-1986
DNM2	2448	738
DPEP2	-808	-6530
DPYD	4241	-135
DSE	4401	-6498
DSEL	-524	-4
DTYMK	-3263	-174
DUT	-1865	1287
ECHS1	-676	-1673
ECI1	149	-4832
ECI2	-4551	-2127
ECSIT	1839	-4938
EEF1E1	-624	-1336
EEFSEC	-3562	-1968
EHHADH	2477	-6438
ELOVL1	3022	-1168
ELOVL4	-2134	-2987
ELOVL5	2406	-3408
ELOVL6	-4374	-1124
ENO1	4084	-6654
ENO2	-2862	639
ENO3	-2238	-4590
ENOPH1	-3699	1736
ENPP2	603	-2276
ENTPD1	3775	2446
ENTPD4	-2006	-1106
ENTPD5	-1913	-4305
ENTPD6	-1456	-5875
ENTPD7	3568	626
EP300	2471	-4509
EPHX1	-3505	-6422
EPHX2	-3649	-5989
ERCC2	1210	-594
ESD	2665	-4602
ESRRA	2372	-2927
ESYT1	-4827	959
ESYT2	-4484	-1193
ETFA	3955	709
ETFB	3368	-3921
ETFDH	3601	868
ETHE1	3983	-651
ETNK1	-436	1286
EXT1	3030	-5359
EXT2	-437	-1799
FABP5	2411	-3534
FADS1	3374	-4312
FADS2	458	-5605
FAH	4393	-5132
FAHD1	49	-6373
FAM120B	-4	-2607
FAR1	4009	-224
FASN	-223	1100
FAU	-124	-3862
FBP1	3159	-4762
FDFT1	3180	-4585
FDPS	2049	124
FDX1	579	-3747
FDXR	1776	-3448
FECH	2900	-3650
FH	924	-575
FIG4	4210	-5382
FITM2	-1868	-2082
FLAD1	-2817	1221
FLVCR1	-2770	-1280
FPGS	-3899	1728
FUT10	-1682	-3470
FUT11	-4805	-37
FUT4	3149	-6552
FXN	-4398	-619
G6PC3	1360	-6318
GAA	3545	-3801
GALC	3834	264
GALE	1893	-105
GALK1	4060	-2705
GALT	-3174	-325
GAPDH	4353	1359
GBA	4133	-5623
GBA2	957	-4419
GCDH	-709	-4658
GCH1	-2404	-2007
GCHFR	2065	316
GCLC	-4505	-1829
GCLM	2080	-248
GCSH	-2762	-4566
GDE1	3946	-5040
GDPD1	-1367	-1268
GDPD5	-3955	-2713
GGCT	-2026	-2907
GGPS1	-339	-2782
GGT1	4376	-6607
GGT7	-2899	-3
GLB1	3992	1368
GLCE	3998	258
GLIPR1	3403	-2351
GLO1	-1108	-3115
GLRX	3525	-3309
GLRX5	3912	1149
GLS	-4610	-4781
GLTP	3852	-5867
GLUD1	2174	-2194
GLUL	4152	-6758
GLYCTK	-1175	-1256
GM2A	4180	-825
GMPR	3871	-5096
GMPR2	3355	-2545
GMPS	-1653	-1416
GNA15	4391	-6690
GNAI2	3616	-1747
GNAQ	4145	-6733
GNAS	3508	951
GNB1	3736	-2920
GNB2	3650	-309
GNB4	3163	-6007
GNB5	163	1821
GNG2	-2538	-3847
GNG3	285	2231
GNG4	-649	2073
GNG5	4043	1920
GNG7	-1581	-4773
GNGT2	-4735	2438
GNPDA1	3889	-210
GNPDA2	-2931	-2636
GNS	4348	-571
GOT1	-4520	190
GOT2	-3445	-1064
GPAM	-3683	-4630
GPC2	-1277	-6477
GPCPD1	3878	-203
GPD1	-2182	-6250
GPD1L	-3809	-2487
GPD2	3277	-6521
GPHN	-2250	-4806
GPI	2558	-2211
GPS2	-293	-857
GPT2	-480	-6135
GPX1	4327	-5467
GPX4	1957	-455
GRHPR	326	1463
GSR	4276	-4724
GSS	224	-1739
GSTA4	-2828	-4624
GSTK1	-494	1037
GSTM3	-563	-6312
GSTM4	370	-4359
GSTO1	4196	-170
GSTO2	-950	1658
GSTP1	35	-5415
GSTZ1	2108	701
GUK1	2106	91
GUSB	3389	-4967
GYG1	4157	-5541
GYS1	3067	-1092
HACD1	1663	-4245
HACD2	-520	1513
HACD3	-4020	2329
HACD4	2893	500
HACL1	-4541	-3683
HADH	-4341	-4809
HADHA	3974	1866
HADHB	4389	-968
HAGH	1935	-4846
HDAC3	1727	-3771
HEXA	391	-4273
HEXB	4022	-5777
HIBADH	-2839	-4592
HIBCH	-871	-1008
HILPDA	-485	670
HK1	4188	479
HK2	4296	-5015
HLCS	-4516	1551
HMBS	2305	-2717
HMGCL	2059	1969
HMGCR	3626	-3388
HMGCS1	-595	-2608
HMMR	1323	-3568
HMOX2	-4583	2130
HPD	3304	-3768
HPGD	3208	-6446
HS3ST3B1	-2852	-4926
HS6ST1	1651	-5621
HSCB	943	-3590
HSD17B1	1250	1940
HSD17B11	3570	-3328
HSD17B12	3082	-895
HSD17B4	4069	-5528
HSD17B8	-3941	2077
HSP90AA1	411	-781
HSP90AB1	-2171	-5745
HYAL1	1475	-6777
HYAL2	4198	-5951
HYAL3	1999	847
IDH1	4409	-2333
IDH2	-933	-798
IDH3A	-3209	-1594
IDH3B	-472	-2553
IDI1	3116	1929
IDUA	-1794	932
IL4I1	-3638	-6308
IMPA1	-221	-1820
IMPA2	4407	-505
IMPDH1	4313	-750
IMPDH2	-3507	446
INPP1	-505	-6045
INPP4A	-3365	2209
INPP5A	2898	-5525
INPP5B	-2241	-5762
INPP5D	-1207	-3735
INPP5E	-2803	2080
INPP5F	-1476	507
INPP5K	-610	1585
INPPL1	4166	-2224
INSIG1	-3893	947
INSIG2	2643	-4256
IP6K1	1414	930
IP6K2	-3901	-878
IPMK	3575	1897
IPPK	1090	-6048
IQGAP1	3661	1271
ISCA1	2561	-2023
ISCU	-551	70
ITPA	-2795	-3773
ITPK1	2880	-2385
ITPKB	-4396	1418
ITPKC	4046	-5392
ITPR1	-2478	-3278
ITPR2	2315	-6107
ITPR3	-3717	-3427
IVD	-4836	-3067
KCNJ11	-1226	-2105
KHK	-2309	-1547
KMO	-2089	-5979
KPNB1	776	-2176
L2HGDH	-3499	-3657
LBR	3631	-3506
LCLAT1	-59	-2733
LDHA	3941	-4161
LDHB	-3520	-3504
LDLR	2505	-494
LGMN	-1401	313
LHPP	1	-2536
LIAS	-1835	-4260
LIPE	-3191	-5437
LIPT1	-4263	1548
LIPT2	-2664	-4195
LMBRD1	2725	-156
LPCAT1	-2399	1540
LPCAT3	3925	-3100
LPCAT4	-2836	1628
LPGAT1	3906	-5760
LPIN1	-4350	-2651
LPIN2	-2200	2060
LRP10	3010	2161
LRP12	2574	-6362
LRP8	1675	-214
LRPPRC	-3590	-5728
LSS	-3858	-4805
LTA4H	4292	-972
LTC4S	-121	-6617
LYPLA1	3652	184
LYRM4	-1852	623
MAN2B1	2897	-6345
MAN2B2	1534	-4433
MAN2C1	-1128	928
MANBA	3188	1807
MAPKAPK2	1428	2012
MAT2A	-1306	1455
MAT2B	-3753	-2153
MBOAT1	2139	-4287
MBOAT7	3885	-3703
MBTPS1	955	-398
MCAT	2113	-3215
MCCC1	-3067	-4716
MCCC2	-4605	1857
MCEE	-1430	320
MDH1	630	-461
MDH2	1492	2515
ME2	2919	504
ME3	-3570	-4969
MECR	-2366	350
MED1	-1206	-2271
MED10	-2893	-2572
MED11	-181	609
MED13	807	590
MED13L	2440	-533
MED15	-3434	2114
MED16	2024	1719
MED17	1004	-1418
MED18	1590	-186
MED19	1074	-4664
MED20	2814	-542
MED21	-1826	-582
MED22	1321	-2059
MED23	-2139	633
MED24	-2380	-2701
MED25	2518	-1286
MED26	1589	18
MED27	-3167	-960
MED28	-445	699
MED29	-2631	-5128
MED30	-1669	491
MED31	447	445
MED4	1062	-4472
MED6	-279	560
MED7	62	778
MED8	3267	1289
MED9	-2996	-3399
MFSD2A	-690	-5062
MGST2	3984	-6536
MGST3	2743	-524
MINPP1	-348	-1874
MLX	3864	-3367
MLYCD	-3346	97
MMAA	-4375	-3965
MMAB	-3102	-850
MMACHC	-2175	-266
MMADHC	2563	-3748
MMS19	-2576	1975
MOCOS	1172	-6155
MOCS2	-3228	-3611
MOCS3	-2115	-4731
MORC2	-3367	2508
MPC2	1668	-216
MPST	3470	-6010
MSMO1	818	1922
MTAP	-1778	-5878
MTF1	4102	-2992
MTHFD1	-4360	1071
MTHFD1L	112	-4124
MTHFD2	3721	-541
MTHFR	1895	-5449
MTHFS	3840	195
MTMR10	3542	-3555
MTMR12	-513	-579
MTMR14	3586	-4278
MTMR2	-664	519
MTMR3	4187	-2340
MTMR4	951	-1420
MTMR6	3487	1477
MTMR9	443	-2578
MTR	-4685	448
MTRR	629	-694
MVD	-1805	1954
MVK	-2769	-2474
N6AMT1	-4268	1363
NADK	3423	-4598
NADK2	-2289	1853
NADSYN1	1137	-2603
NAGLU	-1444	-5716
NAGS	984	-4627
NAMPT	3260	1077
NAPRT	3205	-6164
NAT1	2802	-6568
NCOA2	343	1407
NCOA3	1198	-2266
NCOA6	2280	-1860
NCOR1	2341	-3738
NCOR2	3557	-4281
NDC1	-4789	-5228
NDST2	3496	-5041
NDUFA10	-2227	-3014
NDUFA11	445	-5059
NDUFA12	-525	-3525
NDUFA13	1512	-4567
NDUFA2	1863	-867
NDUFA3	157	-23
NDUFA4	2661	288
NDUFA5	-1429	1424
NDUFA6	2404	-3626
NDUFA7	2199	-770
NDUFA8	1785	-3780
NDUFA9	-3017	-3913
NDUFAB1	2272	-395
NDUFAF1	3669	-5134
NDUFAF2	672	-2692
NDUFAF3	2952	-5045
NDUFAF4	-3577	493
NDUFAF5	-3304	-6281
NDUFAF6	-694	-5694
NDUFB1	3295	-4478
NDUFB10	2298	-599
NDUFB2	-1323	1946
NDUFB3	3826	-1362
NDUFB4	1667	1157
NDUFB5	1351	-1595
NDUFB7	724	358
NDUFB9	3709	-6083
NDUFC1	2055	563
NDUFC2	2451	-4977
NDUFS1	2593	1355
NDUFS2	2443	-6412
NDUFS3	283	-2069
NDUFS4	1396	438
NDUFS5	2502	1325
NDUFS6	1468	-853
NDUFS7	667	-1679
NDUFS8	23	-733
NDUFV1	-4369	-5982
NDUFV2	1537	-2346
NDUFV3	1985	-1432
NEU1	4167	-3878
NEU3	-1138	-1409
NFYA	1189	1464
NFYB	-3536	-531
NFYC	3345	-3078
NHLRC1	-1716	-5836
NME1	534	-318
NME2	576	-4319
NME3	-212	-5409
NME4	1982	-6601
NMNAT1	4272	-1129
NMNAT3	-787	-5984
NMRAL1	-2196	182
NMRK1	-1063	2135
NNT	1601	-5319
NOS3	-620	-1770
NOSIP	-2158	-3257
NQO1	-935	-5372
NQO2	3907	-3750
NR1D1	-3070	1187
NR1H2	3207	-1471
NR1H3	-1069	-2305
NRF1	-2712	-4642
NT5C	-3242	-3125
NT5C2	3930	-6291
NT5C3A	1617	-5395
NT5M	2380	-3759
NUBP1	1642	-1534
NUBP2	-3271	1053
NUDT1	-1005	1174
NUDT12	-532	-5327
NUDT13	-1658	-6538
NUDT15	-890	-1515
NUDT16	4101	-6171
NUDT18	1212	-1364
NUDT19	2682	1908
NUDT3	2251	-3971
NUDT4	3211	-6105
NUDT5	-1058	1842
NUDT7	341	593
NUDT9	2007	-898
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
OAT	4042	-4268
OAZ1	4268	865
OAZ2	4041	-1403
OAZ3	-1324	-4957
ODC1	1082	-3950
OGDH	1455	1211
ORMDL1	-1831	-584
ORMDL3	-3550	-2716
OSBP	-792	-3696
OSBPL2	1941	-2911
OSBPL3	-4657	375
OSBPL5	-4802	-6730
OSBPL7	-4536	-4735
OSBPL8	2939	-2735
OSBPL9	2623	-2108
OXCT1	-4509	1553
PAICS	-1633	-839
PANK1	56	-5190
PANK2	3298	-5941
PANK3	960	-3008
PANK4	-2902	2199
PAOX	-4024	2169
PAPSS1	4151	1297
PARP10	-2818	2302
PARP14	-4614	864
PARP16	-4591	678
PARP4	1574	-715
PARP6	-1506	-3268
PARP8	-2825	-759
PARP9	-1314	1117
PC	4293	-5175
PCBD1	3025	-436
PCCB	-2627	-6219
PCK2	-220	-4164
PCTP	4357	-3451
PCYT1A	2857	822
PCYT2	-4291	-2669
PDHB	1506	-3400
PDHX	1535	1616
PDK1	1516	-2149
PDK2	-2655	-941
PDP1	-1270	-1207
PDP2	-4219	-2658
PDPR	-2355	-784
PDSS1	3320	-6036
PDSS2	2804	-1857
PDXK	3939	-5028
PECR	4000	2064
PEMT	1014	-4605
PEX11A	-2998	-2595
PFAS	-4116	-1753
PFKFB2	3533	-3582
PFKFB3	3954	-4955
PFKFB4	4300	-3233
PFKL	-977	-5964
PFKM	-326	-4441
PFKP	-1046	-2229
PGAM1	4383	-2347
PGD	4402	-2827
PGLS	2442	-2660
PGM1	2316	-4799
PGM2	4341	-1959
PGM2L1	1108	-1267
PGP	135	-3352
PGS1	3952	-5906
PHGDH	1095	-3513
PHKB	4040	-2130
PHKG2	506	-2649
PHOSPHO1	947	-430
PHYKPL	2317	1811
PI4K2A	-2085	-355
PI4K2B	-4673	-317
PI4KA	-782	-5
PI4KB	-1333	1292
PIAS4	1971	-3982
PIK3CA	1703	-1445
PIK3CD	2422	2189
PIK3CG	569	-2045
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R3	-4692	-22
PIK3R4	-1215	-3425
PIK3R5	-688	514
PIKFYVE	1048	-2382
PIP4K2A	-707	1772
PIP4K2B	-2535	-6347
PIP4K2C	-4309	-5573
PIP5K1A	2460	-348
PIP5K1C	1151	-5383
PISD	4093	-4659
PITPNB	-2252	-4909
PITPNM1	2289	873
PITPNM2	-1464	2520
PITPNM3	-1020	1888
PKM	4362	-3076
PLA2G12A	2244	-5029
PLA2G15	4005	-3722
PLA2G4C	-859	-4912
PLA2G6	-4758	-3132
PLB1	4405	-5279
PLCB2	1721	-3046
PLCB3	4097	-5846
PLCD1	-2934	-2598
PLCD3	4345	-1196
PLCG1	-4158	-3541
PLCG2	1884	-2562
PLD1	4321	-6058
PLD3	3177	1541
PLD6	-1150	2227
PLEKHA2	-419	-4384
PLEKHA3	-1543	-6547
PLEKHA6	-528	-2325
PLEKHA8	-923	-1764
PLIN2	3718	-96
PLIN3	4385	-3203
PMVK	1104	1829
PNP	3818	-4436
PNPLA2	4111	-5698
PNPLA6	2889	-3173
PNPLA7	-2176	-1431
PNPLA8	3379	-3836
PNPO	-2000	-5663
PODXL2	-3221	-1347
POLD1	57	-4975
POM121	-2766	-1787
POM121C	-2305	-4315
PON2	-1901	-4741
POR	3839	173
PPA1	606	1448
PPA2	661	-5450
PPARD	-1990	660
PPARGC1B	-1534	1840
PPCDC	-101	-1567
PPCS	2479	-4277
PPIP5K2	2483	-581
PPM1K	-4604	-1728
PPM1L	-1031	-4324
PPOX	-4239	-232
PPP1CA	1435	550
PPP1CB	3004	1839
PPP1CC	2581	-754
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5D	771	-4349
PPT1	4119	-4371
PPT2	-4288	-5624
PRKAB2	-2709	-1428
PRKACA	4378	-6032
PRKACB	-4656	455
PRKAG2	636	-5033
PRKAR1A	3924	-201
PRKAR1B	3514	731
PRKAR2A	2493	-4298
PRKCA	356	810
PRKD2	-3006	229
PSAP	3061	-4192
PSAT1	2723	-5212
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PSPH	2622	-2780
PSTK	-3652	-6128
PTDSS2	2331	-1185
PTEN	3844	-1100
PTGES2	-2198	-1462
PTGES3	1450	-1810
PTGR1	4217	-6711
PTGR2	385	-3930
PTPMT1	693	414
PTPN13	-3534	-6489
PTS	-598	-2642
PXMP2	1162	-2456
PYCR2	-746	-2919
PYGB	152	-5617
QDPR	-1504	-5226
QPRT	-4748	-4760
RAB14	3027	1334
RAB4A	3532	-5479
RAB5A	3035	-1686
RAE1	1963	-39
RAN	-2142	1257
RANBP2	-273	-4704
RAP1A	3148	323
RDH11	2667	-3361
RETSAT	155	-687
RFK	1118	-4148
RGL1	3340	1731
RIMKLB	-4010	-4779
RNLS	1287	-6149
RORA	-4672	2287
RPE	829	-4246
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
RRM1	-4157	-2309
RRM2	-62	-574
RRM2B	2842	-5757
RTEL1	-1338	-5696
RUFY1	2621	-4178
SACM1L	-3188	-1578
SAMD8	3315	-5347
SAMHD1	2619	-2016
SAR1B	2676	489
SARDH	-3085	-6693
SBF1	-3835	882
SC5D	-1097	-6658
SCAP	-1253	-3851
SCD	1416	-6126
SCLY	-2742	-875
SCO1	-3455	-1715
SCO2	-1303	-4657
SCP2	1625	-5793
SDC4	2758	1193
SDHA	-1703	-3404
SDHB	3301	-5123
SDHC	3798	-4120
SEC13	2266	-3749
SEC23A	3162	-5141
SEC24A	3350	61
SEC24B	1233	-5505
SEC24C	-768	805
SEC24D	3637	-3966
SEH1L	-1875	-1615
SEPHS2	3343	-2239
SERINC1	2287	-3455
SERINC3	2705	806
SERINC4	-383	1220
SERINC5	-1092	924
SGMS1	4025	-1653
SGPL1	1110	-2339
SGPP1	-4810	-5414
SHMT1	-231	-4063
SHMT2	-1482	-4020
SHPK	-754	1029
SIN3A	-3818	-4151
SIN3B	-1256	570
SLC16A1	1626	576
SLC16A3	4026	-6120
SLC19A1	4048	-1094
SLC19A2	-1227	-880
SLC22A5	2925	-5659
SLC23A1	-1298	-6481
SLC25A1	1857	-910
SLC25A11	3135	-419
SLC25A12	-1443	-2638
SLC25A13	-138	-6258
SLC25A15	-2878	-5407
SLC25A16	104	-2820
SLC25A17	-3849	-4326
SLC25A19	554	-1682
SLC25A20	1381	2245
SLC25A28	-814	1449
SLC25A32	-3331	-2299
SLC25A37	4373	-3601
SLC25A44	3351	729
SLC26A2	-873	-2627
SLC27A1	3744	-3528
SLC27A2	-1137	-6055
SLC27A3	-258	-1585
SLC27A5	-1076	-3060
SLC2A1	-4221	1930
SLC2A3	4160	-4757
SLC35B2	-3671	-2200
SLC35B3	2161	-554
SLC35D1	-2187	-2789
SLC36A4	3346	-4355
SLC37A1	-1791	-5144
SLC37A2	746	-5258
SLC37A4	-1973	-3038
SLC3A2	1993	-1667
SLC44A1	3877	2368
SLC44A2	861	2003
SLC5A5	-1625	-5772
SLC5A6	-1717	-2437
SLC7A5	976	-6143
SLC9A1	3546	-753
SMPD1	355	-28
SMPD2	793	-918
SMPD3	-4824	2463
SORD	3989	-1871
SP1	3686	-3141
SPHK2	914	-2294
SPTLC1	3914	-5493
SPTLC2	3893	743
SPTLC3	581	1742
SPTSSA	1715	-5079
SQLE	1494	-5831
SRD5A1	3535	2146
SRD5A3	1390	442
SREBF1	2701	-4015
SREBF2	2792	-1852
SRM	-2298	753
ST3GAL1	-2406	1767
ST3GAL2	3958	-2686
ST3GAL3	158	-1055
ST3GAL4	2285	-4996
ST3GAL6	2794	-5427
ST6GALNAC6	-4734	2144
STARD10	1786	-337
STARD3	1116	-5163
STARD3NL	3182	-4610
STARD4	-1221	-2360
STARD5	-883	-5368
STARD7	1146	-1506
STK11	723	-5709
STX1A	-1213	-2461
STXBP1	-1871	-5365
SUCLA2	3279	-1756
SUCLG1	2381	-1488
SUCLG2	-1775	964
SUMF1	4144	-5376
SUMF2	-4706	-3692
SURF1	1204	-4976
SYNJ1	2565	1501
SYNJ2	-2867	-6043
SYT5	2162	-5209
TACO1	1600	-5534
TALDO1	4392	-5245
TBL1XR1	1669	962
TBXAS1	4073	-6709
TECR	-3264	-274
THEM4	-4130	-6129
THTPA	-1044	-2617
TIAM2	-4087	-1035
TK1	1709	-3071
TK2	4275	-5591
TKT	4340	1166
TM7SF2	-2418	-1255
TMEM126B	-2792	-5677
TMEM186	-1247	-381
TNFAIP8	-152	1226
TNFAIP8L1	-3518	-4062
TNFAIP8L2	2226	-249
TPI1	2837	-5027
TPK1	-978	-2721
TPMT	1608	-5097
TPR	-2242	-973
TPST1	4286	-2233
TPST2	2256	-2387
TRAP1	-3984	-3024
TRIB3	-1802	1669
TRMT112	233	-4666
TSPO	4344	-6553
TST	3406	2225
TSTD1	-2717	-1659
TXN	3732	284
TXN2	1714	-257
TXNRD1	3685	-4647
TYMP	1003	-5857
TYMS	144	-1783
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2I	-245	233
UBIAD1	-3848	-245
UCK1	1808	-5092
UCK2	-3624	-5243
UCKL1	-1839	-5219
UCP2	291	331
UGCG	2541	1914
UGDH	1434	-1951
UGP2	3140	-1297
UPP1	3917	-3833
UQCR11	2913	-6004
UQCRB	1332	-2785
UQCRC1	3472	-3413
UQCRC2	2322	1661
UQCRFS1	2577	618
UQCRH	3614	-6511
UQCRQ	953	-2641
UROD	1861	-4709
UROS	-4395	-4479
UST	-4530	-5056
VAC14	-38	-2381
VAMP2	-4559	-2770
VAPA	4169	-5592
VAPB	687	-6771
VDAC1	1566	-3624
VDR	3768	-3651
VKORC1	2807	557
WASL	87	-4742
XYLB	-3645	-2724
XYLT1	-2387	-5426
XYLT2	-1431	-3343
ZDHHC21	-2007	-3185

---

---

Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol

metric	value
setSize	147
pMANOVA	5.25e-11
p.adjustMANOVA	4.69e-09
s.dist	0.342
s.RNA	-0.283
s.meth	0.193
p.RNA	3.83e-09
p.meth	5.68e-05

Top 20 genes

Gene	RNA	meth
NOP14	-4022	2384
RRP9	-3589	2034
RPL3	-2885	2313
RPL23A	-3334	1843
EXOSC2	-4132	1269
NOL9	-3670	1426
RPS11	-2332	2115
RPL13A	-2727	1802
EXOSC8	-4363	1020
SNU13	-2174	1961
RPL32	-2103	1928
RPP38	-2263	1598
WDR75	-3509	1028
NOC4L	-1668	1990
RPS2	-1344	2392
RPL35	-2671	952
RPL4	-1064	2321
RPS10	-1780	1246
EXOSC5	-1377	1591
NOL6	-4043	526

Click HERE to show all gene set members

All member genes

	RNA	meth
BMS1	-4492	-2552
BYSL	-1331	-88
C1D	1194	510
CSNK1D	760	-1777
CSNK1E	-3709	-4750
DCAF13	-1698	-2001
DDX21	1018	760
DDX47	-4257	-3056
DDX49	1815	-4408
DDX52	142	-1954
DHX37	-2753	-312
DIS3	-1292	-762
EBNA1BP2	-1224	1600
ERI1	2157	130
EXOSC1	-319	-290
EXOSC10	-4315	-1580
EXOSC2	-4132	1269
EXOSC3	161	-2555
EXOSC4	3305	-4410
EXOSC5	-1377	1591
EXOSC6	-3464	545
EXOSC7	-3889	-4665
EXOSC8	-4363	1020
FAU	-124	-3862
FBL	-3651	-2611
FCF1	1633	-2675
FTSJ3	-1200	-670
GNL3	-2859	-1419
HEATR1	-3738	-1985
IMP3	-3288	99
IMP4	-4084	-2925
ISG20L2	1309	1893
KRR1	-2907	-6562
LTV1	-1284	-3205
MPHOSPH10	-2537	-57
MPHOSPH6	685	-5463
NCL	-3204	-2515
NIP7	-1813	-1760
NOB1	-3724	-1000
NOC4L	-1668	1990
NOL11	-3807	-2629
NOL12	1851	505
NOL6	-4043	526
NOL9	-3670	1426
NOP14	-4022	2384
NOP56	-4540	-523
NOP58	-3529	-2406
PDCD11	-4401	-2174
PELP1	-4054	-1579
PES1	-609	-3908
PNO1	-2170	-5495
PWP2	-378	681
RBM28	-4493	-685
RCL1	-244	-1421
RIOK1	-1131	-2098
RIOK2	300	-954
RIOK3	4013	-2443
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPP14	974	-354
RPP21	-1631	-5256
RPP25	-2741	-5917
RPP30	-2675	-5522
RPP38	-2263	1598
RPP40	-1467	-1426
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
RRP1	-924	77
RRP7A	-846	-2961
RRP9	-3589	2034
SENP3	966	-1248
SNU13	-2174	1961
TBL3	-1027	994
TEX10	-3427	-1947
TSR1	-3410	-3041
UBA52	349	752
UTP15	-3872	-2796
UTP18	1940	-3819
UTP20	-3834	-1372
UTP3	-874	-3665
UTP6	-1347	-1904
WDR12	1988	706
WDR18	-691	-2042
WDR3	-2064	-5710
WDR36	-1177	-2277
WDR43	-2494	-4225
WDR75	-3509	1028
XRN2	4366	-5589

---

---

Post-translational protein modification

Post-translational protein modification

metric	value
setSize	890
pMANOVA	7.82e-11
p.adjustMANOVA	6.49e-09
s.dist	0.134
s.RNA	0.121
s.meth	0.0581
p.RNA	2.95e-09
p.meth	0.00431

Top 20 genes

Gene	RNA	meth
FURIN	4191	2351
SOCS3	4399	2178
SIAH2	3910	2185
PHC2	4171	1830
KDELR1	4226	1780
RNF146	3975	1789
FKBP8	3911	1784
TMED7	3534	1939
RNF123	2846	2363
CUL3	2861	2054
NOD2	3833	1528
PPP6C	2859	2020
TUBB4B	3111	1856
DAD1	2346	2452
GLB1	3992	1368
NSMCE1	2425	2210
PSMA7	3028	1752
PSMD1	3112	1660
RHOA	3753	1313
TAF10	3039	1606

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
ACTB	4156	-4515
ACTL6A	-2416	-4851
ACTR10	3309	-1291
ACTR1A	2965	-1
ACTR5	-4212	-3829
ACTR8	-1483	-5628
ADAM10	4030	976
ADAMTS10	-4118	-5260
ADAMTS13	-1309	958
ADAMTS17	-1134	463
ADAMTS6	-2253	1076
ADAMTSL4	3263	1378
ADAMTSL5	-2776	-6404
ADRB2	-4624	-3531
ADRM1	1378	589
AGBL2	-3181	-5272
AGBL3	-3255	-646
AGBL5	1195	-3128
AGTPBP1	3757	-1941
ALG10	-2662	-346
ALG10B	-2740	966
ALG11	-1067	-549
ALG12	849	-1300
ALG14	2265	1103
ALG2	-391	-625
ALG3	-392	-2680
ALG5	-228	-2175
ALG6	513	-4449
ALG8	-1083	-3591
ALG9	-3428	-1148
AMDHD2	-3859	539
AMFR	3176	-6742
ANK1	4018	-4221
ANK3	-1491	-6563
ANKRD28	-1940	-5108
ANKRD9	3621	-635
ANO8	2454	384
APC	1073	-4775
APLP2	4343	-3465
APP	4249	-5300
ARCN1	2180	-1676
ARF1	4184	-6686
ARF3	3396	-1912
ARF4	4256	-3280
ARF5	3493	-4789
ARFGAP1	-582	1688
ARFGAP3	1282	-5386
ARRB1	632	-6363
ARRB2	3860	-2243
ARSA	1183	-3099
ARSB	3290	-5722
ARSG	-1448	152
ARSK	-4182	-54
ASB1	1105	1900
ASB13	1106	-5265
ASB2	-4671	-2230
ASB6	-832	-6098
ASB7	2524	-4653
ASB8	1819	998
ASXL1	-3718	-4360
ASXL2	580	-1790
ATXN3	495	1703
ATXN7	-599	759
AURKA	1109	-385
AURKB	269	-889
AXIN1	-3703	-5655
AXIN2	-2699	-4719
B3GALNT2	-14	-1560
B3GNT2	2332	-1684
B3GNT7	-4854	-6593
B3GNT8	4117	-6681
B3GNTL1	2148	-2656
B4GALT1	1540	-160
B4GALT2	-1862	1307
B4GALT3	-3962	-4680
B4GALT4	121	-1422
B4GALT5	4052	52
B4GALT6	-2986	-6484
B4GAT1	-1725	451
BABAM1	-296	-1937
BAP1	352	1999
BARD1	-1019	-2910
BCL10	2320	-3261
BECN1	2690	459
BET1	-192	-4482
BET1L	-2389	332
BIRC2	1737	-1862
BIRC3	-4159	-2320
BIRC5	1291	-84
BLM	-1418	-2909
BMI1	-3460	-6383
BRCA1	2542	-4609
BTBD1	715	-5321
BTBD6	-1584	-136
BTRC	-1493	-2427
C1GALT1	-1285	-3509
CALM1	-626	-5019
CALR	2586	-3753
CALU	3497	1252
CAND1	-2041	-421
CANX	2151	-4839
CAPZA1	3648	572
CAPZA2	3920	-36
CAPZB	3576	-4065
CASP8AP2	-3688	231
CBX4	699	-5288
CBX8	2112	2207
CCNA2	520	-1132
CCNF	-3202	-4258
CD55	4229	-3923
CD59	2326	-6024
CDC20	1401	116
CDC25A	938	-1711
CDC34	3927	-2454
CDC73	1891	-2092
CDCA8	-553	472
CDK1	472	-4215
CDKN2A	-1595	-4511
CHD3	-3413	422
CHST10	-4598	-5927
CISH	1836	1748
CKAP4	4355	-6717
CLSPN	1244	-1524
CMAS	4057	-2712
CNIH1	3425	-6699
COG1	-4760	-3663
COG2	-2597	-6132
COG3	-1652	-5701
COG4	-3	-984
COG5	-970	-1864
COG6	-1787	-358
COG7	1526	-4196
COG8	-118	1846
COMMD1	2334	-4720
COMMD10	1528	171
COMMD2	1054	782
COMMD3	-426	-6772
COMMD4	-1391	-5750
COMMD5	2137	-1140
COMMD6	-334	-2702
COMMD7	1997	2040
COMMD8	3171	187
COMMD9	3544	-4811
COPA	3780	1056
COPB1	3154	-1329
COPB2	3503	-1501
COPE	2906	213
COPS2	2476	896
COPS3	2403	-2950
COPS4	549	-3507
COPS5	1573	-1617
COPS6	508	-866
COPS7A	2731	-565
COPS7B	-3432	538
COPS8	-2966	-4126
COPZ1	1422	-5051
COPZ2	-4019	1305
CPM	2992	-4667
CREBBP	1153	-5804
CSF1	-622	-5924
CSNK1D	760	-1777
CTBP1	-2010	2394
CTR9	1117	-5535
CTSA	4412	-4847
CTSC	739	1561
CTSZ	4137	-6765
CUL1	-4281	-5146
CUL2	805	-1212
CUL3	2861	2054
CUL4A	-1459	1876
CUL5	265	-3077
CUL7	-995	-2524
CUL9	-1888	-5978
CYLD	-3240	1406
DAD1	2346	2452
DAG1	-2376	-146
DAXX	-3855	-450
DCAF10	1841	1341
DCAF11	-729	-1493
DCAF13	-1698	-2001
DCAF16	-4522	-4367
DCAF17	-4304	986
DCAF4	-4265	1739
DCAF5	-3380	-3273
DCAF6	3762	-2743
DCAF7	-523	683
DCAF8	-3484	-439
DCTN2	4235	-6011
DCTN3	2396	-4272
DCTN4	3796	-2073
DCTN5	-1222	-5100
DCTN6	3145	819
DCUN1D2	-1460	318
DCUN1D3	1560	-429
DCUN1D4	-3553	-2024
DCUN1D5	274	-5390
DDA1	1025	606
DDB2	-4408	-561
DDX17	-1953	206
DDX5	-3465	1288
DDX58	-4651	-1002
DERL1	-3060	123
DERL2	987	-2287
DHDDS	-673	-4895
DHPS	166	-149
DNAJC24	-3956	1293
DNAJC3	3828	-2353
DNMT1	-4835	1294
DNMT3A	-911	-6002
DNMT3B	1541	1185
DOHH	-506	-1316
DOLK	-1085	-2245
DOLPP1	919	-914
DPAGT1	678	650
DPH1	-4289	-3723
DPH2	-4099	-486
DPH3	3458	-3670
DPH5	93	1156
DPH7	-3975	-5720
DPM1	482	-2366
DPM2	1751	-1939
DPM3	823	-2637
DTL	131	-5529
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNLL1	2378	-3319
DYNLL2	-1189	214
EDEM1	-36	1523
EDEM2	3982	-3093
EEF1A1	-1549	720
EEF2	90	2127
EEF2KMT	-3471	2078
EID3	-4615	-328
EIF5A	174	-363
ENGASE	-2450	-5741
EP300	2471	-4509
EPAS1	3494	535
ERCC8	1035	-5536
ETFB	3368	-3921
FBXL12	-407	292
FBXL14	-1899	2358
FBXL15	1641	-4502
FBXL16	-2077	-4011
FBXL18	1098	-5248
FBXL19	3931	-6239
FBXL20	1804	-993
FBXL22	-3179	562
FBXL3	318	-4101
FBXL4	2136	-5130
FBXL5	4370	-6189
FBXL8	1413	-479
FBXO11	2793	-500
FBXO15	-394	647
FBXO21	-3979	-933
FBXO22	-1105	1132
FBXO30	1733	-609
FBXO31	-4652	480
FBXO32	-3875	-1875
FBXO4	-4600	-4056
FBXO6	-687	234
FBXO7	3250	-3059
FBXO9	4374	-3674
FBXW11	2510	-6747
FBXW2	2712	-3711
FBXW4	-4543	1993
FBXW5	76	-194
FBXW7	-2055	-5428
FBXW8	-3557	-2504
FEM1A	612	-82
FEM1B	1610	1880
FKBP8	3911	1784
FN3KRP	-4213	1195
FOXK1	-1539	-5199
FOXK2	1123	-6253
FPGT	3127	-2826
FSTL3	4310	88
FUCA1	3203	-5579
FUCA2	3743	-427
FUOM	-1578	-5803
FURIN	4191	2351
FUT8	-3421	-2455
GALNT10	-997	-6074
GALNT11	-942	-3318
GALNT12	-3477	-5876
GALNT2	4061	-5164
GALNT3	557	-2941
GALNT4	3012	-180
GALNT6	-263	-6156
GALNT7	3699	57
GAN	-440	-2479
GANAB	-317	-3501
GATA3	-4799	1861
GBF1	-1279	-120
GCNT1	3791	179
GFPT1	-2014	-2828
GGCX	2003	-3236
GLB1	3992	1368
GMDS	1849	-1375
GMPPA	1347	-4201
GMPPB	-2358	1238
GNE	-1580	-4921
GNPNAT1	-3379	-2849
GOLGA2	2513	1847
GOLGB1	-1635	-3196
GOLM1	-2162	-6094
GORASP1	2742	-2178
GOSR1	-61	-3152
GOSR2	-454	1643
GPAA1	2395	-843
GPS1	-1352	-6247
HDAC1	184	-1016
HDAC2	2129	-46
HDAC4	4126	-3817
HDAC7	2465	-4900
HGS	1647	2123
HIF1A	3219	-3349
HIPK2	2441	-1520
HLA-A	-771	-5991
HLA-B	205	1015
HNRNPC	2536	-1112
HNRNPK	3259	-2386
HSP90B1	647	-1371
ICMT	-252	-71
IDE	2996	-777
IFIH1	-4282	-4856
IGFBP4	-2464	-6569
IKBKE	1750	2086
INCENP	-1832	-2850
ING2	1603	-2115
INO80	-2950	-74
INO80B	-588	-3700
INO80C	2537	-3246
INO80D	-1594	-869
INO80E	-2619	-2832
JOSD1	64	-3051
JOSD2	3524	-957
KAT2A	-3970	-5050
KAT2B	-722	-1588
KBTBD6	870	327
KBTBD7	2608	-1326
KBTBD8	-1262	-4094
KCTD6	1579	886
KCTD7	-4415	-602
KDELR1	4226	1780
KDELR2	3393	-2980
KDM1B	1918	1468
KEAP1	1826	-2872
KIN	1197	617
KLHL11	-1956	186
KLHL2	4247	-4276
KLHL20	-4381	-2781
KLHL21	1909	-1243
KLHL22	-4331	-899
KLHL25	-3912	-464
KLHL5	1936	-4208
KTN1	1126	-2404
L3MBTL2	-3969	-4114
LAMB2	156	-2207
LEO1	10	791
LGALS1	4168	-79
LMAN1	-3888	596
LMAN2	3016	-2497
LMAN2L	2928	-1590
LMO7	-3402	2419
LRR1	-2482	1362
LRRC41	3257	404
LTBP1	3541	-4651
LYPD3	-2349	-4231
MAN1A1	3520	-447
MAN1A2	-619	-1465
MAN1B1	-1477	2249
MAN1C1	-2148	-1205
MAN2A1	-418	-4486
MAN2A2	2751	-5172
MANEA	-226	172
MAP3K7	761	-2089
MAT2B	-3753	-2153
MAVS	3048	-4500
MBD1	639	-1177
MBD5	831	-6395
MBD6	3323	-5542
MBTPS1	955	-398
MCFD2	3031	-158
MCRS1	-2750	1266
MDC1	-4716	-902
MDM2	1551	-1318
MDM4	-385	-2440
MEN1	-2877	-2311
METTL21A	1191	1437
METTL22	1960	2176
MFGE8	1205	-527
MGAT1	2546	1169
MGAT2	507	-1666
MGAT4A	-1741	-2254
MGAT4B	3961	-6439
MGAT5	-918	-5572
MIA3	-1938	-3428
MLEC	737	953
MOGS	-913	-2356
MPDU1	3413	-1260
MPI	-3963	-5890
MUC1	2718	-5557
MUC12	-3930	-5807
MUC5B	-1389	2353
MUL1	954	-3003
MVD	-1805	1954
MYSM1	-2379	-616
NAE1	-4057	897
NAGK	1038	-5552
NANP	-3279	-585
NANS	3538	529
NAPA	438	-4125
NAPB	-838	471
NAPG	1458	-97
NCOA2	343	1407
NCOR2	3557	-4281
NDC1	-4789	-5228
NEDD8	2677	-1600
NEGR1	446	-6424
NEU1	4167	-3878
NEU3	-1138	-1409
NEURL2	-930	2421
NFKB2	-367	388
NFKBIA	2851	1159
NFRKB	-868	-3238
NGLY1	-1096	-236
NICN1	-550	-2869
NLRP3	4089	-6357
NOD1	-4837	-5170
NOD2	3833	1528
NOP58	-3529	-2406
NPL	4408	-6573
NR1H2	3207	-1471
NR1H3	-1069	-2305
NR1I2	-1321	-4903
NR2C1	-3506	-1463
NR3C1	162	-2420
NR3C2	-3885	324
NR4A2	-490	1416
NSMCE1	2425	2210
NSMCE2	2329	-6425
NSMCE4A	-4195	-4495
NTNG2	2189	903
NUB1	-4677	1450
NUCB1	4079	-5498
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
NUS1	3476	-9
OS9	4087	-975
OTUB1	430	-5956
OTUD3	-3966	-1582
OTUD7B	-4742	-2644
OTULIN	-219	1535
P4HB	3831	-1549
PAF1	1180	-5838
PARK7	2635	-821
PARP1	-4548	-5521
PCNA	-1833	-511
PDIA3	1451	1466
PDIA6	2339	1837
PEX10	-2043	1348
PEX12	-2965	-2164
PEX13	178	-1839
PEX14	1024	-3892
PEX2	948	-5892
PEX5	1502	-6491
PGAP1	-2987	-660
PGM3	-297	1964
PHC1	-2820	-5180
PHC2	4171	1830
PHC3	-2698	1805
PIAS1	3175	-2534
PIAS2	-2430	-2314
PIAS3	-422	1855
PIAS4	1971	-3982
PIGC	-455	-2121
PIGF	2736	-1570
PIGH	-3275	-1358
PIGK	-1847	-2040
PIGL	-4517	-1793
PIGM	16	-4141
PIGN	575	-3172
PIGO	-2995	-2601
PIGP	-1572	-3043
PIGQ	553	-2760
PIGS	2984	-749
PIGT	306	-1299
PIGU	-3173	-504
PIGV	-545	-2037
PIGW	-4526	1896
PIGX	2084	-5421
PLAUR	3822	-6237
PML	-2938	549
PMM1	1483	-1060
PMM2	428	-2687
PNPLA2	4111	-5698
POFUT2	-3868	1983
POLB	-2444	-1516
POM121	-2766	-1787
POM121C	-2305	-4315
POMGNT1	-4644	-826
POMGNT2	-1230	-6177
POMK	-577	-1346
POMT1	-2925	1390
POMT2	193	-669
PPP6C	2859	2020
PPP6R1	2015	-1276
PPP6R3	1081	-3726
PRKCSH	1991	-3007
PRKDC	-3668	1316
PRMT3	522	-372
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTEN	3844	-1100
PTP4A2	820	2110
PTRH2	1691	-4375
PUM2	-604	-801
QSOX1	4315	-1087
RAB10	4103	-3437
RAB11A	3969	-2965
RAB11B	1596	-387
RAB12	-284	-1635
RAB14	3027	1334
RAB18	3438	-1995
RAB19	1545	-3370
RAB1A	4176	-1703
RAB1B	3749	-264
RAB22A	-1258	-3947
RAB23	331	-2847
RAB24	2063	-3725
RAB26	-1325	2425
RAB27A	3811	-1181
RAB29	-3648	282
RAB2A	3923	-2810
RAB2B	-3071	-557
RAB30	-3466	-2803
RAB33B	3130	547
RAB34	3819	-3968
RAB35	1394	780
RAB37	-4565	-5384
RAB3A	3646	-1080
RAB3D	4263	-6515
RAB40B	-4312	1177
RAB40C	3694	8
RAB43	2645	1154
RAB4A	3532	-5479
RAB4B	1028	1318
RAB5A	3035	-1686
RAB5B	2790	-2055
RAB5C	3953	-1152
RAB6A	3657	-311
RAB7A	4002	-5570
RAB8A	1346	-1289
RAB8B	2696	79
RABGGTA	-734	1696
RABGGTB	-1597	2306
RAD18	-4637	812
RAD21	527	702
RAD23A	2689	-3621
RAD23B	4081	-3906
RAD52	-327	-2399
RAE1	1963	-39
RANBP2	-273	-4704
RANGAP1	-4525	1644
RARA	2642	-5249
RBBP5	328	-779
RBX1	1368	-3241
RCE1	-1412	-282
RCN1	-3967	-2128
RECK	-2791	-4325
RELA	-542	2085
RFT1	1549	147
RHOA	3753	1313
RHOT1	4352	-5271
RING1	-1216	-1490
RNF103	-1360	-2036
RNF123	2846	2363
RNF135	3897	-6458
RNF139	842	354
RNF146	3975	1789
RNF152	1085	-1925
RNF168	-1297	1626
RNF181	2412	312
RNF185	2681	-2775
RNF2	1192	-1936
RNF20	2258	-799
RNF40	2752	-5137
RNF5	-1999	-4625
RNF7	3510	-1943
RORA	-4672	2287
RPA1	-4688	-2495
RPN1	3580	-2841
RPN2	3058	-688
RPS2	-1344	2392
RPS27A	-2201	-2138
RRAGA	2539	-1657
RTF1	1201	-4613
RTN4RL2	2907	-6031
RUVBL1	-2905	256
RWDD3	-82	-4374
SAE1	-2761	2410
SAFB	838	-3542
SAR1B	2676	489
SATB1	-2592	-1979
SATB2	2834	-6456
SCMH1	-1799	1397
SEC13	2266	-3749
SEC16A	1697	-1722
SEC22A	-1537	696
SEC22C	-1264	1879
SEC23A	3162	-5141
SEC23IP	-154	-38
SEC24A	3350	61
SEC24B	1233	-5505
SEC24C	-768	805
SEC24D	3637	-3966
SEC31A	346	-4985
SEH1L	-1875	-1615
SEL1L	2877	-2307
SENP1	-2622	-1254
SENP2	1418	-382
SENP5	-2097	261
SENP8	1005	-1816
SHISA5	393	1884
SHPRH	-2810	-353
SIAH2	3910	2185
SIN3A	-3818	-4151
SKP1	1536	-2290
SKP2	-2759	-1566
SLC17A5	1875	-3631
SLC35A1	3104	-4021
SLC35C1	880	-5366
SMAD1	3872	-3272
SMAD2	1830	-1994
SMAD3	-4538	-4628
SMAD4	-2796	-6535
SMAD7	-4617	-4450
SMC3	-596	-1642
SMC5	-2264	-2372
SMC6	-1275	1981
SMURF2	-3735	-3048
SOCS2	-757	378
SOCS3	4399	2178
SOCS5	1047	-4583
SP100	1552	-769
SP3	2133	-3116
SPON2	-4842	1081
SPSB1	756	-3865
SPSB3	-1858	-4699
SPTAN1	-4344	-1250
SPTBN1	-2529	-3924
SPTBN5	-1052	2344
SRD5A3	1390	442
ST3GAL1	-2406	1767
ST3GAL2	3958	-2686
ST3GAL3	158	-1055
ST3GAL4	2285	-4996
ST3GAL5	-4428	1507
ST3GAL6	2794	-5427
ST6GAL1	-4715	1948
ST6GALNAC3	4221	145
ST6GALNAC4	-207	-5981
ST6GALNAC6	-4734	2144
ST8SIA1	-2612	-2246
ST8SIA4	3708	-3013
STAG1	-1977	-863
STAM	397	770
STAM2	2488	-2181
STAMBP	498	-93
STAMBPL1	-3882	-5600
STT3A	1442	-4222
STX17	-4100	-4247
STX5	3071	-1823
SUDS3	1652	-1851
SUMF1	4144	-5376
SUMF2	-4706	-3692
SUMO1	2903	-3986
SUMO3	2991	-5577
SVBP	3085	-4594
SYVN1	313	-5153
TAF10	3039	1606
TBC1D20	-8	-5205
TDG	2782	621
TFPT	2035	-333
TGFA	4083	-3020
TGFB1	1959	-6
TGFBR1	486	-6163
TGFBR2	1359	-5224
TGOLN2	3988	-2836
THRA	-1986	-2798
TMED10	94	604
TMED2	2424	-3656
TMED3	868	-2936
TMED7	3534	1939
TMED9	3072	-1992
TMEM115	2141	-703
TMEM129	1383	1624
TNFAIP3	-4067	-785
TNIP1	3790	-2256
TNIP2	2166	-5726
TNKS	-2959	-1583
TNKS2	-161	-449
TOMM20	-824	2451
TOP1	3338	-2610
TOP2A	891	192
TOP2B	-819	-3244
TOPORS	915	462
TP53	-4034	-739
TP53BP1	-4095	-2967
TPGS1	1616	1697
TPGS2	-947	-4475
TPR	-2242	-973
TPST1	4286	-2233
TPST2	2256	-2387
TRAF2	-4539	-1442
TRAF3	-1701	2379
TRAF6	-80	-6118
TRAPPC1	3441	-3029
TRAPPC10	-3243	2388
TRAPPC2L	-686	1441
TRAPPC3	3041	-2853
TRAPPC4	-2106	-3231
TRAPPC5	1974	-5629
TRAPPC6A	-4050	1765
TRAPPC6B	1463	-662
TRAPPC9	2048	-4354
TRIM13	-675	497
TRIM25	3700	-3718
TRIM27	3651	-1744
TRIM28	-1538	1191
TRRAP	-2111	1860
TTL	-1235	-4334
TTLL1	-2474	-5225
TTLL11	-1603	-5747
TTLL12	2062	1569
TTLL3	-699	-2560
TTLL4	3502	-4814
TTLL5	-1231	-3569
TTLL7	2551	-1018
TUBA1A	3150	-4767
TUBA1B	2142	-1058
TUBA1C	3089	-150
TUBB2A	3956	-4771
TUBB4B	3111	1856
UAP1	-4784	-3110
UBA2	-2022	1399
UBA3	3420	-2122
UBA52	349	752
UBA6	1163	1251
UBB	2759	-1321
UBC	1618	-2568
UBE2B	2966	-2486
UBE2C	1933	1091
UBE2D1	4255	-1581
UBE2D2	1717	-3799
UBE2D3	3944	-373
UBE2E1	2822	-5882
UBE2E3	1883	-5759
UBE2F	3165	-3774
UBE2G1	1840	-1626
UBE2G2	-2650	-3560
UBE2H	3352	-1867
UBE2I	-245	233
UBE2J2	3722	-368
UBE2K	2901	1379
UBE2L3	3281	-3496
UBE2M	3239	-3585
UBE2N	607	1127
UBE2Q2	-4419	-4146
UBE2R2	3894	-3277
UBE2S	1766	2449
UBE2T	-2946	-2989
UBE2V2	934	-3487
UBE2W	3522	-618
UBE2Z	-4046	-4538
UBXN1	595	-2222
UBXN7	481	-1320
UCHL3	616	-752
UCHL5	-2570	-6243
UGGT1	1923	-3498
UHRF2	-3522	-1716
UIMC1	4261	-3114
USO1	1467	1196
USP10	3272	-5328
USP12	1868	-4528
USP13	-2120	-667
USP14	-1600	-5011
USP15	2481	686
USP16	-2598	1533
USP18	-4814	-2616
USP19	-150	492
USP20	-4386	2238
USP21	-2215	-3841
USP22	2770	-3087
USP24	-4261	1979
USP25	48	1721
USP28	-4863	-3970
USP3	3978	-267
USP30	271	-2625
USP33	-274	-5582
USP34	-310	-4481
USP4	3446	-5610
USP42	-4306	-3364
USP44	-2526	-4859
USP47	-1181	-3304
USP48	1593	-4606
USP49	837	1872
USP5	-1874	-173
USP7	2576	-2216
USP8	2632	-424
VASH1	420	1394
VCP	2902	-2411
VCPIP1	-90	-476
VCPKMT	99	-631
VDAC1	1566	-3624
VDAC3	134	1058
VDR	3768	-3651
VHL	1262	1389
WAC	2018	53
WDR20	-331	-4288
WDR48	-4427	-5481
WDR5	39	-5613
WDR61	22	-4752
WDTC1	2833	-205
WFS1	-3431	409
WRN	-4713	-2102
WSB1	3475	-637
WSB2	3405	-6513
XPC	-4359	-402
XRCC4	2821	-3706
YKT6	1980	-3331
YOD1	3265	-556
YY1	169	-5165
ZBTB16	215	2289
ZNF131	-4251	-423

---

---

rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol

metric	value
setSize	154
pMANOVA	1.28e-10
p.adjustMANOVA	9.89e-09
s.dist	0.328
s.RNA	-0.274
s.meth	0.18
p.RNA	4.78e-09
p.meth	0.000129

Top 20 genes

Gene	RNA	meth
NOP14	-4022	2384
RRP9	-3589	2034
RPL3	-2885	2313
RPL23A	-3334	1843
EXOSC2	-4132	1269
NOL9	-3670	1426
RPS11	-2332	2115
RPL13A	-2727	1802
EXOSC8	-4363	1020
SNU13	-2174	1961
RPL32	-2103	1928
RPP38	-2263	1598
WDR75	-3509	1028
NOC4L	-1668	1990
RPS2	-1344	2392
RPL35	-2671	952
RPL4	-1064	2321
RPS10	-1780	1246
EXOSC5	-1377	1591
NOL6	-4043	526

Click HERE to show all gene set members

All member genes

	RNA	meth
BMS1	-4492	-2552
BYSL	-1331	-88
C1D	1194	510
CSNK1D	760	-1777
CSNK1E	-3709	-4750
DCAF13	-1698	-2001
DDX21	1018	760
DDX47	-4257	-3056
DDX49	1815	-4408
DDX52	142	-1954
DHX37	-2753	-312
DIS3	-1292	-762
EBNA1BP2	-1224	1600
ERI1	2157	130
EXOSC1	-319	-290
EXOSC10	-4315	-1580
EXOSC2	-4132	1269
EXOSC3	161	-2555
EXOSC4	3305	-4410
EXOSC5	-1377	1591
EXOSC6	-3464	545
EXOSC7	-3889	-4665
EXOSC8	-4363	1020
FAU	-124	-3862
FBL	-3651	-2611
FCF1	1633	-2675
FTSJ3	-1200	-670
GAR1	-2203	-4416
GNL3	-2859	-1419
HEATR1	-3738	-1985
IMP3	-3288	99
IMP4	-4084	-2925
ISG20L2	1309	1893
KRR1	-2907	-6562
LTV1	-1284	-3205
MPHOSPH10	-2537	-57
MPHOSPH6	685	-5463
NCL	-3204	-2515
NHP2	-1038	-260
NIP7	-1813	-1760
NOB1	-3724	-1000
NOC4L	-1668	1990
NOL11	-3807	-2629
NOL12	1851	505
NOL6	-4043	526
NOL9	-3670	1426
NOP10	3759	-3526
NOP14	-4022	2384
NOP2	-3530	-2438
NOP56	-4540	-523
NOP58	-3529	-2406
PDCD11	-4401	-2174
PELP1	-4054	-1579
PES1	-609	-3908
PNO1	-2170	-5495
PWP2	-378	681
RBM28	-4493	-685
RCL1	-244	-1421
RIOK1	-1131	-2098
RIOK2	300	-954
RIOK3	4013	-2443
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPP14	974	-354
RPP21	-1631	-5256
RPP25	-2741	-5917
RPP30	-2675	-5522
RPP38	-2263	1598
RPP40	-1467	-1426
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
RRP1	-924	77
RRP7A	-846	-2961
RRP9	-3589	2034
SENP3	966	-1248
SNU13	-2174	1961
TBL3	-1027	994
TEX10	-3427	-1947
THUMPD1	-3443	-4292
TRMT112	233	-4666
TSR1	-3410	-3041
TSR3	1337	1167
UBA52	349	752
UTP15	-3872	-2796
UTP18	1940	-3819
UTP20	-3834	-1372
UTP3	-874	-3665
UTP6	-1347	-1904
WDR12	1988	706
WDR18	-691	-2042
WDR3	-2064	-5710
WDR36	-1177	-2277
WDR43	-2494	-4225
WDR75	-3509	1028
XRN2	4366	-5589

---

---

Diseases of signal transduction by growth factor receptors and second messengers

Diseases of signal transduction by growth factor receptors and second messengers

metric	value
setSize	265
pMANOVA	1.36e-10
p.adjustMANOVA	9.89e-09
s.dist	0.24
s.RNA	0.24
s.meth	0.0141
p.RNA	2.5e-11
p.meth	0.695

Top 20 genes

Gene	RNA	meth
QKI	4147	2193
PPP2CB	3381	1797
MAPK1	3249	1865
BCL2L11	3187	1781
YWHAB	2611	2125
PPP1CB	3004	1839
PAPSS1	4151	1297
PSMA7	3028	1752
PIK3CD	2422	2189
APH1B	2555	2056
BCL2L1	3979	1306
PSMD1	3112	1660
CHUK	3543	1343
CBL	3241	1456
IQGAP1	3661	1271
PSME3	3715	1116
ADAM10	4030	976
RAC1	4031	971
KSR1	1477	2466
PSMD12	2710	1314

Click HERE to show all gene set members

All member genes

	RNA	meth
ADAM10	4030	976
ADAM17	3634	774
AGGF1	2507	-3806
AGK	-4757	-3004
AGTRAP	4122	-6548
AKAP9	-1528	-3186
AKT1	1234	-1942
AKT1S1	3477	-2319
AKT2	133	-141
AP3B1	3779	-3148
APBB1IP	4003	-5120
APC	1073	-4775
APH1A	1453	-6066
APH1B	2555	2056
ARRB1	632	-6363
ARRB2	3860	-2243
ATG7	3647	569
AXIN1	-3703	-5655
BAD	2904	-1382
BAG4	3756	-3089
BCL2L1	3979	1306
BCL2L11	3187	1781
BCR	-2261	-6682
BIN2	2264	-2805
BRAF	403	-4347
BRAP	2076	-3662
CALM1	-626	-5019
CAMK2D	-4581	-2867
CAMK2G	601	2354
CASP9	3366	-234
CBL	3241	1456
CCNC	589	-1138
CDK8	-594	-5509
CDKN1A	1646	-3540
CDKN1B	-2723	-862
CHUK	3543	1343
CLCN6	703	-775
CNTRL	-2072	-6676
CPSF6	-1897	2374
CREB1	-430	-672
CREBBP	1153	-5804
CSK	1990	862
CSNK1A1	3419	769
CTBP1	-2010	2394
CTNNB1	2626	-1691
CUL1	-4281	-5146
CUX1	4142	-2129
DERL2	987	-2287
DUSP10	-503	-1469
DUSP16	-2082	-2622
DUSP6	1570	-6763
DUSP7	-960	-1322
EP300	2471	-4509
ERBB2	-4865	-5145
ERLEC1	217	-2711
ERLIN2	4104	-4042
ESR2	-3194	-2661
ETV6	2110	-6394
FBXW7	-2055	-5428
FGF9	-2970	1634
FGFR1OP2	3455	-2734
FIP1L1	-2603	-2274
FKBP1A	4177	-4465
FLT3LG	-3495	1573
FOXO1	-3290	-5036
FOXO3	3966	711
FRS2	-1025	-1999
FXR1	2034	-1166
FYN	-4495	1957
FZD5	4411	-2513
FZD6	-2030	-6235
FZD8	-2285	-6560
GAB2	3629	-6153
GOLGA4	-1217	-155
GOLGB1	-1635	-3196
GRB2	4320	-2295
GSK3A	3415	-2192
GSK3B	2756	736
GTF2F1	1854	-1723
GTF2F2	2104	-2885
HBEGF	1889	-6428
HDAC1	184	-1016
HDAC10	721	-1304
HDAC11	1771	-3595
HDAC2	2129	-46
HDAC3	1727	-3771
HDAC4	4126	-3817
HDAC5	1746	-3144
HDAC7	2465	-4900
HEY2	-3420	2330
HHAT	-3216	-5389
HRAS	-1008	-4780
HSP90AA1	411	-781
IQGAP1	3661	1271
IRS1	533	-4060
IRS2	3903	-5410
JAK2	857	-1751
KANK1	-1183	-270
KAT2A	-3970	-5050
KAT2B	-722	-1588
KRAS	1276	440
KSR1	1477	2466
LCK	-4596	2489
LMNA	1348	-6474
LRP5	1538	1949
LRP6	180	-4544
LRRFIP1	2568	-1040
MAML1	2088	-5348
MAML2	-189	-2078
MAML3	4123	-4054
MAP2K1	4183	-698
MAP2K2	2840	-3962
MAP3K11	3325	-2732
MAPK1	3249	1865
MAPK3	4121	-2448
MAPKAP1	1911	1057
MARK3	3976	-3461
MDM2	1551	-1318
MIB1	-896	-2718
MLST8	117	287
MPRIP	-4075	755
MTOR	-3429	-1813
MYO18A	-1185	-6701
NCBP1	-1807	-3745
NCBP2	-3329	-4067
NCOR1	2341	-3738
NCOR2	3557	-4281
NCSTN	4254	-3821
NF1	985	-2145
NOTCH1	1743	1722
NR4A1	-2128	657
OS9	4087	-975
PAPSS1	4151	1297
PDPK1	2474	167
PEBP1	-4246	-152
PHB	-894	-3178
PIK3AP1	3445	-4753
PIK3CA	1703	-1445
PIK3CD	2422	2189
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R3	-4692	-22
PIM1	3377	-5227
PLCG1	-4158	-3541
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
PPP1CB	3004	1839
PPP1CC	2581	-754
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5A	2347	381
PPP2R5B	2831	-6343
PPP2R5C	-4242	2376
PPP2R5D	771	-4349
PPP2R5E	-217	-2288
PRR5	-4676	-1591
PSEN1	3540	-3407
PSEN2	-2508	-5155
PSENEN	2260	-3620
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTEN	3844	-1100
PTPN11	2038	-2302
PTPN12	3660	-1077
QKI	4147	2193
RAC1	4031	971
RAC2	1962	-868
RAF1	3488	-314
RAP1A	3148	323
RAP1B	1058	-1031
RBPJ	4017	-1118
RBX1	1368	-3241
RHOG	3858	860
RICTOR	-3383	1651
RPS27A	-2201	-2138
RPS6KB2	218	1145
SEL1L	2877	-2307
SHC1	1472	-2954
SHOC2	3161	-3532
SKP1	1536	-2290
SMAD2	1830	-1994
SMAD3	-4538	-4628
SMAD4	-2796	-6535
SND1	1338	-1905
SNW1	1979	946
SOS1	-1748	-6775
SPRED1	-2916	-6227
SPRED2	2927	521
SPRED3	-2159	-4087
SPTBN1	-2529	-3924
SRC	-2999	-4427
STAT1	-4529	2195
STAT3	3628	-3606
STAT5A	2943	-6427
STAT5B	2923	-3446
STRN	1272	1051
SYVN1	313	-5153
TBL1XR1	1669	962
TCF7L2	-1917	-3431
TGFA	4083	-3020
TGFB1	1959	-6
TGFBR1	486	-6163
TGFBR2	1359	-5224
TLN1	3876	191
TNKS	-2959	-1583
TNKS2	-161	-449
TRIM24	1322	-5752
TRIP11	-187	1568
TSC2	-262	895
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
VAV1	3499	-3184
VCL	3157	-5870
VCP	2902	-2411
WDR48	-4427	-5481
YES1	-4772	-4415
YWHAB	2611	2125
ZC3HAV1	-3578	1635
ZFYVE9	-2566	-4766
ZMYM2	1129	-896

---

---

Gene expression (Transcription)

Gene expression (Transcription)

metric	value
setSize	1006
pMANOVA	1.81e-10
p.adjustMANOVA	1.24e-08
s.dist	0.128
s.RNA	-0.128
s.meth	-0.00741
p.RNA	3.31e-11
p.meth	0.701

Top 20 genes

Gene	RNA	meth
MOV10	-4681	-6449
ZNF530	-4722	-6175
ZKSCAN8	-4228	-6728
ZNF568	-4485	-6314
ZNF528	-4227	-6459
ZNF354C	-4210	-6378
AUTS2	-4738	-5652
ZNF211	-4299	-6023
ZNF549	-4632	-5587
CCND2	-4535	-5700
PARP1	-4548	-5521
NDC1	-4789	-5228
ERBB2	-4865	-5145
ZNF620	-4534	-5485
ZNF550	-4164	-5905
ZNF43	-4578	-5370
ZNF70	-4592	-5340
ZNF287	-4785	-5090
ZNF571	-4564	-5324
CNOT6L	-4229	-5686

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
ABL1	63	-4891
ACTB	4156	-4515
ACTL6A	-2416	-4851
AEBP2	-3156	-1677
AFF4	419	-5010
AGO1	2217	1997
AGO2	967	2447
AGO3	-324	-6442
AKT1	1234	-1942
AKT2	133	-141
ALYREF	2102	-4902
ANAPC1	-4659	403
ANAPC10	-1520	-6111
ANAPC11	2490	344
ANAPC15	4132	-1379
ANAPC16	-640	-4507
ANAPC2	-2390	-1007
ANAPC4	-2075	-1696
ANAPC5	-4080	-2530
ANAPC7	-1573	1560
ANG	4135	93
APAF1	4158	-2104
ARID1A	1797	-6716
ARID1B	-1675	1093
ARID2	-1173	-657
ARID3A	3913	-4723
ARID4B	-13	-1226
ASH2L	2400	-3791
ATAD2	-3906	-1835
ATM	-4170	202
ATR	-3743	970
ATRIP	-4384	-2737
ATXN3	495	1703
AURKA	1109	-385
AURKB	269	-889
AUTS2	-4738	-5652
AXIN1	-3703	-5655
BANP	214	-4163
BARD1	-1019	-2910
BAX	2357	-3623
BAZ1B	-1308	-691
BAZ2A	-678	-5766
BBC3	-2571	-3845
BCDIN3D	-1081	1299
BCL2L11	3187	1781
BCL6	4248	-299
BDP1	-2308	-3715
BID	2410	844
BIRC5	1291	-84
BLM	-1418	-2909
BMI1	-3460	-6383
BNIP3L	4333	-851
BRCA1	2542	-4609
BRD1	-4094	2465
BRD2	-3390	1256
BRD7	-5	-5008
BRF1	-2975	-3436
BRF2	-242	-279
BRIP1	-4454	-2323
BRPF1	-2319	89
BRPF3	-2062	-937
BTG1	-1583	2084
BTG2	1017	-1900
CALM1	-626	-5019
CAMK2D	-4581	-2867
CAMK2G	601	2354
CAMK4	-3531	1482
CASC3	2005	-2580
CASP1	1501	-1448
CASP10	-1032	-6612
CASP6	-856	-4898
CAT	4214	-3922
CAV1	619	-2432
CBFB	656	-3766
CBX3	1794	-859
CBX4	699	-5288
CBX6	1421	-3511
CBX8	2112	2207
CCNA2	520	-1132
CCNB1	147	1492
CCNC	589	-1138
CCND1	-2214	-6213
CCND2	-4535	-5700
CCND3	3245	905
CCNE1	-4514	-3403
CCNE2	1953	-3396
CCNG1	1818	131
CCNG2	2753	-3720
CCNH	243	-3754
CCNK	923	-6142
CCNT1	-3292	1773
CDC16	-1877	-4152
CDC23	-4259	-707
CDC25C	1865	-2877
CDC40	2845	2242
CDC7	-2568	-202
CDC73	1891	-2092
CDK1	472	-4215
CDK12	-421	-805
CDK13	-2814	-700
CDK2	-1522	1018
CDK4	-4235	-1295
CDK5	3929	-506
CDK5R1	-346	-2113
CDK6	-2015	-2864
CDK7	1983	275
CDK8	-594	-5509
CDK9	-1171	1524
CDKN1A	1646	-3540
CDKN1B	-2723	-862
CDKN2A	-1595	-4511
CEBPB	3564	-5089
CENPJ	-4330	-838
CHD3	-3413	422
CHD4	-1351	-4634
CHEK1	-741	-211
CHEK2	-1302	-2709
CITED2	2659	-104
CITED4	3463	-701
CLP1	2730	-1417
CNOT1	-1273	-4543
CNOT10	-811	-361
CNOT11	663	-2236
CNOT3	2042	565
CNOT4	-399	-3064
CNOT6	1783	-3728
CNOT6L	-4229	-5686
CNOT7	-1154	349
CNOT8	3701	-2054
COX11	-4412	-789
COX14	-471	-3835
COX16	34	-1160
COX19	-2178	-4047
COX20	-1527	-4841
COX4I1	1484	-5506
COX5A	2495	-2944
COX5B	2517	382
COX6A1	1930	-961
COX6B1	2224	-2634
COX6C	220	-1411
COX7A2L	3386	-2476
COX7C	176	-4071
COX8A	2745	-1258
CPSF1	-1130	-6284
CPSF2	3459	-3164
CPSF3	2740	-4860
CPSF4	-3261	134
CRADD	1987	-4017
CRCP	1795	-577
CREB1	-430	-672
CREBBP	1153	-5804
CSNK2A2	2614	-4422
CSNK2B	1389	-998
CSTF1	-1891	2021
CTDP1	2503	1112
CTLA4	-3751	2506
CTNNB1	2626	-1691
CTR9	1117	-5535
CTSL	1504	-6671
CTSV	-910	-5834
CUL1	-4281	-5146
CYCS	-411	-3927
DAXX	-3855	-450
DDB2	-4408	-561
DDIT3	1831	-3177
DDIT4	-717	-2588
DDX21	1018	760
DEK	853	1060
DGCR8	-4568	-495
DICER1	3710	1032
DNA2	-865	-2087
DNMT1	-4835	1294
DNMT3A	-911	-6002
DNMT3B	1541	1185
DPY30	1300	-1010
DYRK2	-4569	-3036
E2F1	2589	-1005
E2F4	2567	-172
E2F5	-2887	-2646
E2F6	-1514	-2466
E2F7	-1774	-1622
E2F8	918	-4363
EAF1	2153	-4156
EED	-3235	-1174
EHMT1	-2937	-1697
EHMT2	-2883	-1059
EIF4A3	3132	-3850
ELAC2	-4545	-916
ELF1	505	-1733
ELF2	834	-3373
ELL	1886	574
ELL2	3452	-3578
ELL3	192	-2569
EP300	2471	-4509
EPC1	-3513	-2797
ERBB2	-4865	-5145
ERCC2	1210	-594
ERCC3	-2534	969
ERCC6	-3908	-4037
ESR2	-3194	-2661
ESRRA	2372	-2927
EXO1	-488	-3123
EZH2	-3415	-20
FANCC	-4417	-3902
FANCD2	-4343	1778
FANCI	-4640	-4622
FAS	1281	-5824
FBXO32	-3875	-1875
FBXW7	-2055	-5428
FIP1L1	-2603	-2274
FKBP5	4199	-5653
FOS	2120	2149
FOXO1	-3290	-5036
FOXO3	3966	711
FYTTD1	-1781	1459
FZR1	-670	-758
GADD45A	4195	-2249
GATA3	-4799	1861
GATAD2A	999	-256
GATAD2B	-535	-2871
GLS	-4610	-4781
GPAM	-3683	-4630
GPI	2558	-2211
GPS2	-293	-857
GSK3B	2756	736
GSR	4276	-4724
GTF2A1	865	271
GTF2A2	3006	-1036
GTF2B	1193	-3218
GTF2E2	2276	-184
GTF2F1	1854	-1723
GTF2F2	2104	-2885
GTF2H3	-672	1025
GTF2H4	-876	-2761
GTF2H5	1345	691
GTF3A	-2417	-2426
GTF3C1	-2915	2022
GTF3C2	-3190	-872
GTF3C3	-677	1945
GTF3C4	-1416	943
GTF3C5	-1795	1516
GTF3C6	2941	-3181
HDAC1	184	-1016
HDAC10	721	-1304
HDAC11	1771	-3595
HDAC2	2129	-46
HDAC3	1727	-3771
HDAC4	4126	-3817
HDAC5	1746	-3144
HDAC7	2465	-4900
HENMT1	-2800	-27
HEY2	-3420	2330
HIPK1	2325	-974
HIPK2	2441	-1520
HIVEP3	-843	2288
HSP90AA1	411	-781
HSPD1	-562	-2021
HUS1	-45	-522
ICE2	-3053	1344
IL2RA	-2295	-6462
ING2	1603	-2115
ING5	-3565	-763
INTS1	241	-1451
INTS10	1539	-1477
INTS12	47	1798
INTS2	-581	-5323
INTS3	2533	1491
INTS4	-3220	-2255
INTS5	-321	-2452
INTS6	2228	-1482
INTS7	-2590	-3259
INTS8	3618	-1509
INTS9	-2036	-2341
IPO8	1685	-2546
ITCH	407	-1366
ITGA4	-4122	1419
ITGA5	3349	-6767
ITGAL	-4012	2268
IWS1	2345	-60
JARID2	3113	-2338
JMY	-4372	-4364
JUN	1286	69
JUNB	2850	-3031
KAT2A	-3970	-5050
KAT2B	-722	-1588
KAT5	405	-650
KCTD1	-569	-6296
KCTD6	1579	886
KMT2A	-3942	2484
KMT2C	17	-6379
KMT2D	1057	-6199
KMT2E	-1879	2390
KRAS	1276	440
L3MBTL2	-3969	-4114
LAMTOR1	4371	-5950
LAMTOR2	3287	1882
LAMTOR3	3292	321
LAMTOR4	1619	-6150
LAMTOR5	3865	-5095
LBR	3631	-3506
LDB1	-3712	1270
LEO1	10	791
LMO2	3746	-5492
LRPPRC	-3590	-5728
LSM10	2585	-3871
LSM11	-3779	-4172
MAF	-3821	-4350
MAML1	2088	-5348
MAML2	-189	-2078
MAML3	4123	-4054
MAP2K6	4082	-1130
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPKAP1	1911	1057
MAX	1511	-3235
MBD2	2724	582
MBD3	-170	1673
MDC1	-4716	-902
MDM2	1551	-1318
MDM4	-385	-2440
MEAF6	-2677	-3609
MED1	-1206	-2271
MED10	-2893	-2572
MED13	807	590
MED15	-3434	2114
MED16	2024	1719
MED17	1004	-1418
MED20	2814	-542
MED23	-2139	633
MED24	-2380	-2701
MED25	2518	-1286
MED26	1589	18
MED27	-3167	-960
MED30	-1669	491
MED31	447	445
MED4	1062	-4472
MED6	-279	560
MED7	62	778
MED8	3267	1289
MEN1	-2877	-2311
MGA	-3528	-3489
MLLT1	3450	-1901
MLLT3	-3560	1273
MLST8	117	287
MNAT1	-2935	311
MOV10	-4681	-6449
MSH2	-4382	83
MTA2	-2350	1649
MTA3	-3267	-1740
MTERF1	-1641	-5277
MTF2	-1296	501
MTOR	-3429	-1813
MYB	88	1502
MYBBP1A	-4500	-4510
MYBL1	-4803	883
NABP1	3567	-209
NABP2	-2330	-6524
NBN	717	750
NCBP1	-1807	-3745
NCBP2	-3329	-4067
NCOR1	2341	-3738
NCOR2	3557	-4281
NDC1	-4789	-5228
NDRG1	1712	149
NDUFA4	2661	288
NEDD4L	3485	-5066
NELFA	-1157	35
NELFB	115	1822
NELFCD	-1954	2444
NELFE	1342	1377
NFATC2	-4851	2414
NFE2	4380	-6723
NFIA	3639	-2592
NFIC	3857	-2759
NFIX	2006	-6361
NFYA	1189	1464
NFYB	-3536	-531
NFYC	3345	-3078
NOP2	-3530	-2438
NOTCH1	1743	1722
NOTCH4	-1593	-6455
NR1D1	-3070	1187
NR1D2	-3728	663
NR1H2	3207	-1471
NR1H3	-1069	-2305
NR1I2	-1321	-4903
NR2C1	-3506	-1463
NR2C2	-2910	119
NR2C2AP	-4442	-4688
NR3C1	162	-2420
NR3C2	-3885	324
NR4A1	-2128	657
NR4A2	-490	1416
NR4A3	-1547	954
NR6A1	3895	-5344
NRBP1	895	-1365
NUDT21	-1100	13
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
PABPN1	-169	-3743
PAF1	1180	-5838
PAPOLA	3065	775
PARP1	-4548	-5521
PBRM1	2173	2290
PCBP4	-4128	-1359
PCGF5	-989	-3951
PCGF6	-222	-3963
PCNA	-1833	-511
PDPK1	2474	167
PHAX	-1605	694
PHC1	-2820	-5180
PHC2	4171	1830
PHC3	-2698	1805
PHF1	-4216	-1815
PHF19	-4693	-3270
PHF20	-579	904
PIDD1	-2076	-6641
PIN1	-955	-1656
PINK1	4113	-3597
PIP4K2A	-707	1772
PIP4K2B	-2535	-6347
PIP4K2C	-4309	-5573
PLAGL1	139	1666
PLD6	-1150	2227
PLK2	-827	-6257
PLK3	2787	1597
PMAIP1	-4091	-2202
PML	-2938	549
PMS2	-1678	1574
POLDIP3	3131	-5416
POLR1A	-3535	-755
POLR1B	-4104	-1952
POLR1C	-4039	-2688
POLR1D	2715	-2500
POLR1E	-4546	-4471
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
POLR3A	-2354	2213
POLR3C	-2396	509
POLR3D	-4557	1264
POLR3E	-4318	-673
POLR3F	-1579	-5523
POLR3G	-1645	1201
POLR3GL	-2424	-6348
POLR3H	-3719	-510
POLR3K	-737	1383
POLRMT	-3897	-1636
POM121	-2766	-1787
POM121C	-2305	-4315
POU2F1	470	733
POU2F2	1518	950
PPARD	-1990	660
PPARGC1B	-1534	1840
PPM1A	3687	-3764
PPM1D	3444	-4316
PPP1R13B	-4473	1874
PPP1R13L	125	328
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5C	-4242	2376
PRDM1	-3015	799
PRDX1	2981	-877
PRDX2	1157	-5158
PRDX5	3882	-1661
PRKAA1	409	227
PRKAB1	401	-3297
PRKAB2	-2709	-1428
PRKACA	4378	-6032
PRKAG1	2126	-5980
PRKAG2	636	-5033
PRKCB	3029	-4518
PRKCQ	-4762	1372
PRKRA	-3164	-3442
PRMT1	-3186	-740
PRMT5	1232	-2112
PRR5	-4676	-1591
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTEN	3844	-1100
PTPN1	2254	2074
PTPN11	2038	-2302
PTPN4	-4818	-3156
RABGGTA	-734	1696
RABGGTB	-1597	2306
RAD1	-4807	1965
RAD17	-3716	-1101
RAD50	-2373	2067
RAD51	-835	-696
RAD51D	-4336	-710
RAD9A	-4349	-403
RAD9B	1008	-6145
RAE1	1963	-39
RAN	-2142	1257
RANBP2	-273	-4704
RARA	2642	-5249
RARG	-1567	-5402
RB1	3985	-4740
RBBP4	-565	-3282
RBBP5	328	-779
RBBP8	-1554	-5854
RBL1	-3533	-3466
RBL2	-2519	-4497
RBM14	-2431	398
RBPJ	4017	-1118
RBX1	1368	-3241
RELA	-542	2085
RFC2	1853	-1206
RFC3	-3815	-803
RFC4	-3929	624
RFC5	-4518	-4946
RFFL	-515	-5968
RGCC	-2550	2408
RHEB	3356	-2334
RHNO1	-2003	-2816
RICTOR	-3383	1651
RING1	-1216	-1490
RMI2	-1212	1934
RNF111	2267	779
RNF2	1192	-1936
RNF34	-1902	42
RNGTT	1007	-2952
RNMT	-4139	2172
RNPS1	-4345	-3160
RORA	-4672	2287
RPA1	-4688	-2495
RPA3	-3040	-1890
RPAP2	-3047	-3782
RPRD1A	1677	-3000
RPRD2	-1349	-2123
RPS27A	-2201	-2138
RPTOR	-3804	2134
RRAGA	2539	-1657
RRAGC	1856	-2585
RRAGD	4008	-6311
RRM2	-62	-574
RRM2B	2842	-5757
RRN3	-4332	-2882
RTF1	1201	-4613
RUNX1	3262	-4082
RUNX2	-4180	-5055
RUNX3	-4885	2402
RYBP	2154	1520
SAP130	-413	1164
SAP18	1882	-3579
SAP30	3742	-2185
SAP30BP	-2532	-1889
SAP30L	1978	-233
SATB2	2834	-6456
SCMH1	-1799	1397
SCO1	-3455	-1715
SCO2	-1303	-4657
SEC13	2266	-3749
SEH1L	-1875	-1615
SESN1	-3059	-3887
SESN2	1099	-3423
SESN3	-1054	1141
SETD1A	-1763	-2070
SETD1B	231	-5034
SETD9	-389	-6605
SFN	500	-5994
SGK1	1689	-6076
SIN3A	-3818	-4151
SIN3B	-1256	570
SIRT1	-1254	-1775
SIRT3	-3016	-1430
SKI	-4153	-2431
SKIL	-234	-3633
SKP1	1536	-2290
SKP2	-2759	-1566
SLBP	2050	-327
SLC2A3	4160	-4757
SLC38A9	906	-3360
SLU7	871	-3467
SMAD1	3872	-3272
SMAD2	1830	-1994
SMAD3	-4538	-4628
SMAD4	-2796	-6535
SMAD6	3456	-3209
SMAD7	-4617	-4450
SMARCA2	-821	296
SMARCA4	1758	2317
SMARCA5	-689	673
SMARCB1	-1149	-714
SMARCC1	-3025	1327
SMARCC2	-1236	-3828
SMARCD1	-4499	-2643
SMARCD2	2918	967
SMARCE1	-1290	-3418
SMURF1	-780	1321
SMURF2	-3735	-3048
SMYD2	-3787	-3757
SNAPC1	173	343
SNAPC2	1901	-3914
SNAPC3	-2801	-4100
SNAPC4	-271	-6719
SNAPC5	-1124	1443
SNRPB	-718	-2182
SNRPD3	518	1486
SNRPE	194	-919
SNRPG	512	-4002
SNW1	1979	946
SOCS3	4399	2178
SOCS4	-1512	-1919
SOD2	1587	573
SP1	3686	-3141
SPI1	4085	-6766
SRC	-2999	-4427
SREBF1	2701	-4015
SRRM1	-1535	-2963
SRRT	-1601	-3758
SRSF11	-3554	-5151
SRSF2	-1991	2284
SRSF3	-682	-121
SRSF4	1324	-2328
SRSF7	-3031	2075
SRSF9	3210	-3686
SSB	-861	-1312
SSRP1	-4179	-2441
SSU72	1218	-4327
STAT1	-4529	2195
STK11	723	-5709
STUB1	-330	-2168
SUDS3	1652	-1851
SUMO1	2903	-3986
SUPT16H	-4301	-3702
SUPT4H1	930	-1899
SUPT5H	-2108	-3641
SUPT6H	-1995	285
SURF1	1204	-4976
SYMPK	-1895	-2815
TACO1	1600	-5534
TAF10	3039	1606
TAF11	-881	-719
TAF12	3552	-1765
TAF13	3098	-908
TAF15	-2008	-3109
TAF1A	-1829	-3366
TAF1B	-1736	913
TAF1C	-909	-1544
TAF1D	-2057	-5569
TAF2	-1828	-4149
TAF3	-559	-3002
TAF4	-516	-6161
TAF4B	-2666	-1647
TAF5	-1350	1150
TAF6	-2367	1804
TAF7	673	-3426
TAF8	1236	342
TAF9	388	1714
TARBP2	-969	-269
TBL1XR1	1669	962
TCEA1	-309	-4211
TCF12	-386	-4702
TCF3	-2318	-6049
TCF7	-3643	2023
TCF7L2	-1917	-3431
TDG	2782	621
TDRKH	-3601	-2886
TET1	-4074	1694
TET3	3506	2435
TFAM	-1517	-2635
TFAP2E	-1949	-6087
TFDP1	3849	-1587
TFDP2	-4891	-4793
TGFA	4083	-3020
TGFB1	1959	-6
TGIF1	-2933	-5815
TGIF2	-3603	-6609
THOC1	-3681	73
THOC5	3107	747
THOC7	2564	-369
THRA	-1986	-2798
TIGAR	2514	-1893
TMEM219	1336	-6062
TNFRSF10A	561	-3935
TNFRSF10B	3754	1433
TNFRSF10D	4189	-5911
TNKS1BP1	-1672	-5457
TNRC6A	-1710	-5420
TNRC6B	-1353	2270
TOP3A	3549	-3594
TOPBP1	-1033	180
TP53	-4034	-739
TP53BP2	2152	-5830
TP53I3	4139	-6077
TP53INP1	2660	-2058
TP53RK	-4708	-2342
TPR	-2242	-973
TPX2	479	-4637
TRIAP1	82	-3808
TRIM28	-1538	1191
TRIM33	-3001	-2091
TSC1	-638	1527
TSC2	-262	895
TSN	-260	-3199
TSNAX	1523	-80
TTC5	-795	-1440
TTF1	-112	-4199
TXN	3732	284
TXNIP	-3347	-2777
TXNRD1	3685	-4647
U2AF1	398	-5640
U2AF1L4	-1283	2171
U2AF2	1256	-306
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2C	1933	1091
UBE2D1	4255	-1581
UBE2D3	3944	-373
UBE2E1	2822	-5882
UBE2I	-245	233
UBE2S	1766	2449
UBTF	-3563	1582
UHRF1	45	-396
USP7	2576	-2216
VDR	3768	-3651
VEGFA	3235	-2723
WDR33	-2506	-3224
WDR5	39	-5613
WDR61	22	-4752
WRN	-4713	-2102
WWOX	-4138	1732
WWP1	-3604	-1865
XPO5	-3948	-2879
YAF2	-2375	-3920
YEATS4	-1167	1953
YES1	-4772	-4415
YWHAB	2611	2125
YWHAE	4173	-4168
YWHAG	4294	-5545
YWHAH	3949	-2902
YWHAQ	-2362	-2908
YWHAZ	2200	541
YY1	169	-5165
ZC3H8	-3594	-3807
ZFHX3	3213	-2025
ZFP1	-3852	-2240
ZFP14	-3635	1678
ZFP28	-2155	-6320
ZFP30	-4185	-366
ZFP37	-2868	-5928
ZFP90	-3354	824
ZFPM1	-3657	2378
ZIK1	-4120	2035
ZKSCAN1	679	-3843
ZKSCAN3	-2686	-5530
ZKSCAN4	-1570	-5770
ZKSCAN5	413	468
ZKSCAN8	-4228	-6728
ZNF10	-4018	-1897
ZNF101	-1711	2155
ZNF136	-4348	-3471
ZNF138	-4303	-5255
ZNF14	-4209	-4397
ZNF140	-2969	-2581
ZNF141	-3147	-526
ZNF143	3128	-418
ZNF155	-1525	-4127
ZNF160	-3076	-2923
ZNF169	-1933	-737
ZNF17	-3236	-1485
ZNF175	-2613	-5289
ZNF18	-763	-3535
ZNF180	-3911	-2110
ZNF184	-4134	-1046
ZNF189	1184	2001
ZNF19	-4117	907
ZNF2	-2490	-5367
ZNF20	1739	-4807
ZNF200	-49	-1750
ZNF202	-4295	1338
ZNF211	-4299	-6023
ZNF212	-3620	620
ZNF213	2377	-1128
ZNF215	-1104	-2720
ZNF221	-932	-6268
ZNF222	-27	-1983
ZNF223	-2186	-6465
ZNF224	-3540	-2768
ZNF226	-4079	-3429
ZNF227	-3454	-1334
ZNF23	-3922	-3592
ZNF233	-1172	-4234
ZNF234	-2858	-5598
ZNF235	-4402	-5194
ZNF248	-4224	-3321
ZNF25	-1662	-5487
ZNF250	-4622	554
ZNF253	-3902	-1053
ZNF257	-3934	-3813
ZNF26	-3503	-3960
ZNF264	-2391	-4068
ZNF268	-2180	-5808
ZNF274	-2926	-5798
ZNF282	1823	-5468
ZNF286A	-4566	-2915
ZNF287	-4785	-5090
ZNF3	-4783	-1141
ZNF302	-4002	659
ZNF311	-3401	-5855
ZNF324	-3485	-3484
ZNF324B	-4083	651
ZNF331	-2940	-2081
ZNF333	1406	-2425
ZNF337	-4450	-3809
ZNF33A	-2069	157
ZNF33B	-4633	-2030
ZNF34	-1702	-964
ZNF343	-4192	-4524
ZNF354A	1349	-4473
ZNF354C	-4210	-6378
ZNF382	-2513	-4717
ZNF394	408	-628
ZNF398	-1801	155
ZNF417	-1650	-2829
ZNF418	-2453	-6578
ZNF419	-4356	-5268
ZNF420	-3816	-3752
ZNF425	-2185	-4710
ZNF426	-1310	-3104
ZNF43	-4578	-5370
ZNF430	-1468	-4879
ZNF431	-3368	-5647
ZNF432	-4068	-5374
ZNF436	-3527	-5576
ZNF440	-2954	-5938
ZNF443	-1565	-4894
ZNF445	1111	-5606
ZNF446	-3697	-3030
ZNF461	-4655	-2540
ZNF468	-519	-4348
ZNF470	-3363	-6469
ZNF480	-2012	-4983
ZNF483	-3488	-5903
ZNF484	-3318	-304
ZNF490	-788	-2501
ZNF492	-1392	-6580
ZNF496	-4377	-3057
ZNF500	-4575	1026
ZNF506	-3274	-4344
ZNF517	-4437	-228
ZNF528	-4227	-6459
ZNF529	-3806	-3659
ZNF530	-4722	-6175
ZNF540	-4146	-4576
ZNF546	-1454	-1610
ZNF547	-1616	-4822
ZNF549	-4632	-5587
ZNF550	-4164	-5905
ZNF552	1735	-5023
ZNF554	-4479	-1275
ZNF559	-2851	-4261
ZNF561	-1281	-2945
ZNF563	-3853	-5992
ZNF564	-1354	-2468
ZNF566	-4380	-939
ZNF567	-3075	-5136
ZNF568	-4485	-6314
ZNF569	-4403	-352
ZNF570	-4429	-4872
ZNF571	-4564	-5324
ZNF573	-3474	-3023
ZNF582	-3463	-6112
ZNF583	-3403	-4848
ZNF584	-4162	-5742
ZNF585A	-2547	-4862
ZNF585B	-3869	-2710
ZNF587	-52	-1759
ZNF589	-1680	1425
ZNF596	-3483	-6669
ZNF597	-3369	-4633
ZNF600	-4273	-5453
ZNF605	-773	-1335
ZNF606	-3225	-5401
ZNF610	-1916	-6042
ZNF611	-1413	-5441
ZNF613	615	-5448
ZNF614	-3337	-2566
ZNF615	-1623	-5583
ZNF619	-2957	-6317
ZNF620	-4534	-5485
ZNF621	-4107	-3523
ZNF624	-982	-3879
ZNF627	-328	-2790
ZNF641	-2580	-5851
ZNF655	-1035	-2976
ZNF664	-3459	1571
ZNF665	-2634	-6565
ZNF668	1289	1462
ZNF670	-920	-5736
ZNF671	-2540	-680
ZNF677	-3143	-6476
ZNF678	-4108	530
ZNF681	-3034	-3353
ZNF684	-3341	-2033
ZNF688	-2575	-4023
ZNF689	-3330	-4943
ZNF691	-2067	-4147
ZNF692	-1428	-1190
ZNF696	-4504	-3058
ZNF70	-4592	-5340
ZNF700	-1424	-3707
ZNF701	-1059	-6116
ZNF703	-4045	-4320
ZNF706	-1867	-5848
ZNF707	-4368	-4401
ZNF708	-3475	-2881
ZNF709	-3111	-6445
ZNF710	2909	-6541
ZNF713	-1734	-3012
ZNF714	-985	-2480
ZNF717	-2945	-5768
ZNF736	-4506	-4463
ZNF737	-3596	-6022
ZNF74	-4690	-2918
ZNF740	-4355	878
ZNF746	3291	-3816
ZNF747	1377	-451
ZNF749	-3798	-5865
ZNF75A	-2525	-1824
ZNF761	-1788	-3885
ZNF764	-2191	-913
ZNF77	-4137	-489
ZNF771	-2493	-3926
ZNF772	-747	-5966
ZNF774	1767	-1078
ZNF775	1904	-4991
ZNF776	110	-3870
ZNF777	-2229	-4823
ZNF778	-3708	1050
ZNF782	-3127	128
ZNF785	-2244	-5042
ZNF786	-2189	56
ZNF79	-2977	470
ZNF790	-3832	-6139
ZNF791	-2443	-5116
ZNF792	-3008	645
ZNF793	-3375	-6557
ZNF799	-3666	-6025
ZNF839	-659	-6246
ZNF92	-3740	-2695
ZSCAN25	-3311	2482

---

---

Hemostasis

Hemostasis

metric	value
setSize	304
pMANOVA	1.93e-10
p.adjustMANOVA	1.25e-08
s.dist	0.224
s.RNA	0.224
s.meth	0.0014
p.RNA	2.7e-11
p.meth	0.967

Top 20 genes

Gene	RNA	meth
ACTN1	4201	2335
DGKG	3539	2259
GNG5	4043	1920
WDR1	2948	2364
S100A10	2887	2282
PPP2CB	3381	1797
MAPK1	3249	1865
ITGB2	4114	1322
TNFRSF10B	3754	1433
ATP2A2	3591	1489
RHOA	3753	1313
PTPN1	2254	2074
CALU	3497	1252
RAD51B	2041	1987
RAC1	4031	971
STIM1	1369	2500
CFL1	3683	912
GNAS	3508	951
RHOG	3858	860
SDC4	2758	1193

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2170	-3533
AAMP	-1084	-5298
ABCC4	3217	-3153
ABHD12	-3773	-129
ABHD6	-854	-284
ABL1	63	-4891
ACTN1	4201	2335
ACTN4	1907	-2928
AK3	44	-5656
AKAP1	-4353	-1116
AKAP10	3167	-6099
AKT1	1234	-1942
ALDOA	4285	-1349
ANXA5	3692	-2845
APBB1IP	4003	-5120
APLP2	4343	-3465
APP	4249	-5300
ARRB1	632	-6363
ARRB2	3860	-2243
ATP1B1	-3130	111
ATP1B3	-416	1223
ATP2A1	-1409	-4587
ATP2A2	3591	1489
ATP2A3	-299	1190
ATP2B4	-1530	1124
BRPF3	-2062	-937
BSG	4245	-1562
C1QBP	-275	-2507
CABLES2	-2679	939
CALM1	-626	-5019
CALU	3497	1252
CAP1	3635	-553
CAPZA1	3648	572
CAPZA2	3920	-36
CAPZB	3576	-4065
CAV1	619	-2432
CD2	-4574	2510
CD244	-3182	-3183
CD44	3760	266
CD47	-4754	-114
CD48	462	2043
CD58	2766	-3228
CD63	4308	-1017
CD74	-4340	-4283
CD84	1155	-6400
CDC37L1	-2853	1097
CDC42	3268	-2719
CDK2	-1522	1018
CDK5	3929	-506
CEACAM1	3825	-5827
CENPE	98	-4165
CFL1	3683	912
CHID1	909	-254
CRK	4091	-4581
CSK	1990	862
CYB5R1	4394	-1352
DAGLB	2303	-6635
DGKA	-2629	2375
DGKD	-162	546
DGKE	-4323	-953
DGKG	3539	2259
DGKH	-953	-6190
DGKQ	-2697	1446
DGKZ	-1742	-6294
DOCK10	-3945	-5645
DOCK4	3371	697
DOCK7	-708	-5883
DOCK8	2415	-944
DOCK9	-3933	1757
DOK2	-311	-2493
EHD1	1571	-1110
EHD2	2494	-6731
EHD3	1829	-4198
ENDOD1	1124	-4107
F11R	3604	-5665
F12	4406	-1719
FAM3C	-3576	527
FERMT3	4270	-1343
FGR	3853	-5292
FYN	-4495	1957
GATA3	-4799	1861
GLG1	-107	-3693
GNA12	1128	-3386
GNA13	2310	-2285
GNA15	4391	-6690
GNAI2	3616	-1747
GNAI3	3536	-909
GNAQ	4145	-6733
GNAS	3508	951
GNB1	3736	-2920
GNB2	3650	-309
GNB4	3163	-6007
GNB5	163	1821
GNG2	-2538	-3847
GNG3	285	2231
GNG4	-649	2073
GNG5	4043	1920
GNG7	-1581	-4773
GNGT2	-4735	2438
GRB2	4320	-2295
GTPBP2	2582	-487
GYPC	2980	-6224
HABP4	-4052	230
HDAC1	184	-1016
HDAC2	2129	-46
HMG20B	1802	-3649
HRAS	-1008	-4780
INPP5D	-1207	-3735
IRF1	-2866	1887
IRF2	2640	-2044
ITGA1	3994	-4187
ITGA2	1478	-3856
ITGA4	-4122	1419
ITGA5	3349	-6767
ITGA6	-1551	600
ITGAL	-4012	2268
ITGAV	2457	-5201
ITGB2	4114	1322
ITPK1	2880	-2385
ITPR1	-2478	-3278
ITPR2	2315	-6107
ITPR3	-3717	-3427
JAK2	857	-1751
JAM2	67	-2837
JMJD1C	1050	-2964
KCNMB4	2864	-6092
KDM1A	-3266	900
KIF11	250	-4751
KIF13B	2398	-3303
KIF15	-968	-563
KIF16B	894	-6359
KIF18A	-823	-2125
KIF18B	-44	-3342
KIF1B	3681	-4142
KIF20A	1931	-231
KIF20B	-2551	-649
KIF21A	-4595	-1704
KIF21B	-2101	1128
KIF22	-4887	-1801
KIF23	2143	-3340
KIF26B	-4487	-6613
KIF27	812	-1527
KIF2A	-340	1788
KIF2C	229	-1625
KIF3A	-4667	-2118
KIF3B	1292	-2584
KIF3C	3745	-5135
KIF5B	3711	-3520
KIF6	360	-5646
KIF9	1519	-2489
KIFAP3	-2906	1836
KIFC1	-85	901
KIFC2	-499	-5893
KLC1	2149	-1283
KLC2	-3106	-5681
KLC4	-2808	-4132
KRAS	1276	440
LCK	-4596	2489
LCP2	-363	1588
LRP8	1675	-214
MAFF	130	-3863
MAFG	4369	-6073
MAFK	288	-2942
MANF	813	1947
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MFN1	-1508	-659
MFN2	2816	-4801
MICAL1	2434	-4934
MIF	-1146	-2943
MYB	88	1502
NFE2	4380	-6723
NHLRC2	-2558	-716
NOS3	-620	-1770
OLA1	1835	-508
ORAI1	-2269	-4764
ORAI2	2405	-4356
P2RX1	3829	-6722
P2RX4	3328	174
P2RX5	-145	393
P2RX6	-1687	-3907
P2RY1	3468	-5377
PAFAH2	-4866	-1539
PCYOX1L	-605	339
PDE1B	2336	-6326
PDE2A	-265	-391
PDE5A	2786	-5047
PDE9A	-2465	-5405
PDPK1	2474	167
PFN1	2119	833
PHACTR2	2092	-6672
PHF21A	4265	-3398
PICK1	1229	-3746
PIK3CA	1703	-1445
PIK3CG	569	-2045
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R3	-4692	-22
PIK3R5	-688	514
PLAU	1828	-6512
PLAUR	3822	-6237
PLCG1	-4158	-3541
PLCG2	1884	-2562
PLEK	633	-5891
PPIA	-2133	490
PPIL2	-3441	360
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5A	2347	381
PPP2R5B	2831	-6343
PPP2R5C	-4242	2376
PPP2R5D	771	-4349
PPP2R5E	-217	-2288
PRCP	3695	368
PRKACA	4378	-6032
PRKACB	-4656	455
PRKAR1A	3924	-201
PRKAR1B	3514	731
PRKAR2A	2493	-4298
PRKCA	356	810
PRKCB	3029	-4518
PRKCD	4154	584
PRKCE	-2638	-5632
PRKCH	-4868	1376
PRKCQ	-4762	1372
PRKCZ	-4470	-5220
PRTN3	2825	-6448
PSAP	3061	-4192
PTK2	1629	920
PTPN1	2254	2074
PTPN11	2038	-2302
PTPN6	2452	-4586
QSOX1	4315	-1087
RAB5A	3035	-1686
RAC1	4031	971
RAC2	1962	-868
RACGAP1	916	1472
RAD51B	2041	1987
RAF1	3488	-314
RAP1A	3148	323
RAP1B	1058	-1031
RASGRP1	-4668	2119
RASGRP2	-2873	1508
RBSN	-1363	-2813
RCOR1	4190	-4864
RHOA	3753	1313
RHOB	390	-4992
RHOG	3858	860
S100A10	2887	2282
SCCPDH	3431	-5477
SDC4	2758	1193
SELPLG	1546	-1609
SERPINB6	2324	-5578
SERPINB8	4262	-6095
SERPINE2	2655	-6537
SH2B1	-2928	-1068
SH2B3	1358	1699
SHC1	1472	-2954
SIN3A	-3818	-4151
SLC16A1	1626	576
SLC16A3	4026	-6120
SLC3A2	1993	-1667
SLC7A11	-1753	-6233
SLC7A5	976	-6143
SLC7A6	-2098	-2873
SLC8A3	593	-5398
SOD1	-1475	-1019
SOS1	-1748	-6775
SPN	-4895	-3994
SRC	-2999	-4427
SRGN	4011	-2722
SRI	2709	-1804
STIM1	1369	2500
STX4	189	-6001
STXBP2	4170	-6352
STXBP3	3212	-1306
SYK	4192	-5054
TAGLN2	3178	-1136
TEX264	-2805	55
TGFB1	1959	-6
TGFB2	-2429	-6761
TGFB3	-2583	-5946
TLN1	3876	191
TMX3	-249	-6313
TNFRSF10A	561	-3935
TNFRSF10B	3754	1433
TNFRSF10D	4189	-5911
TOR4A	4072	-6704
TP53	-4034	-739
TUBA4A	2678	-4571
VAV1	3499	-3184
VAV2	-1214	-643
VAV3	1824	-6342
VCL	3157	-5870
VEGFA	3235	-2723
VPS45	800	-3464
VTI1B	4065	-359
WDR1	2948	2364
WEE1	-3144	1982
YES1	-4772	-4415
YWHAZ	2200	541
ZFPM1	-3657	2378

---

---

Generic Transcription Pathway

Generic Transcription Pathway

metric	value
setSize	803
pMANOVA	3.15e-10
p.adjustMANOVA	1.92e-08
s.dist	0.137
s.RNA	-0.13
s.meth	-0.0423
p.RNA	9.23e-10
p.meth	0.0473

Top 20 genes

Gene	RNA	meth
MOV10	-4681	-6449
ZNF530	-4722	-6175
ZKSCAN8	-4228	-6728
ZNF568	-4485	-6314
ZNF528	-4227	-6459
ZNF354C	-4210	-6378
AUTS2	-4738	-5652
ZNF211	-4299	-6023
ZNF549	-4632	-5587
CCND2	-4535	-5700
PARP1	-4548	-5521
ERBB2	-4865	-5145
ZNF620	-4534	-5485
ZNF550	-4164	-5905
ZNF43	-4578	-5370
ZNF70	-4592	-5340
ZNF287	-4785	-5090
ZNF571	-4564	-5324
CNOT6L	-4229	-5686
PIP4K2C	-4309	-5573

Click HERE to show all gene set members

All member genes

	RNA	meth
ABL1	63	-4891
ACTL6A	-2416	-4851
AGO1	2217	1997
AGO2	967	2447
AGO3	-324	-6442
AKT1	1234	-1942
AKT2	133	-141
ANAPC1	-4659	403
ANAPC10	-1520	-6111
ANAPC11	2490	344
ANAPC15	4132	-1379
ANAPC16	-640	-4507
ANAPC2	-2390	-1007
ANAPC4	-2075	-1696
ANAPC5	-4080	-2530
ANAPC7	-1573	1560
APAF1	4158	-2104
ARID1A	1797	-6716
ARID1B	-1675	1093
ARID2	-1173	-657
ARID3A	3913	-4723
ASH2L	2400	-3791
ATAD2	-3906	-1835
ATM	-4170	202
ATR	-3743	970
ATRIP	-4384	-2737
ATXN3	495	1703
AURKA	1109	-385
AURKB	269	-889
AUTS2	-4738	-5652
AXIN1	-3703	-5655
BANP	214	-4163
BARD1	-1019	-2910
BAX	2357	-3623
BBC3	-2571	-3845
BCL2L11	3187	1781
BCL6	4248	-299
BID	2410	844
BIRC5	1291	-84
BLM	-1418	-2909
BMI1	-3460	-6383
BNIP3L	4333	-851
BRCA1	2542	-4609
BRD1	-4094	2465
BRD2	-3390	1256
BRD7	-5	-5008
BRIP1	-4454	-2323
BRPF1	-2319	89
BRPF3	-2062	-937
BTG1	-1583	2084
BTG2	1017	-1900
CALM1	-626	-5019
CAMK2D	-4581	-2867
CAMK2G	601	2354
CAMK4	-3531	1482
CASP1	1501	-1448
CASP10	-1032	-6612
CASP6	-856	-4898
CAT	4214	-3922
CAV1	619	-2432
CBFB	656	-3766
CBX3	1794	-859
CBX4	699	-5288
CBX6	1421	-3511
CBX8	2112	2207
CCNA2	520	-1132
CCNB1	147	1492
CCNC	589	-1138
CCND1	-2214	-6213
CCND2	-4535	-5700
CCND3	3245	905
CCNE1	-4514	-3403
CCNE2	1953	-3396
CCNG1	1818	131
CCNG2	2753	-3720
CCNH	243	-3754
CCNK	923	-6142
CCNT1	-3292	1773
CDC16	-1877	-4152
CDC23	-4259	-707
CDC25C	1865	-2877
CDC7	-2568	-202
CDK1	472	-4215
CDK12	-421	-805
CDK13	-2814	-700
CDK2	-1522	1018
CDK4	-4235	-1295
CDK5	3929	-506
CDK5R1	-346	-2113
CDK6	-2015	-2864
CDK7	1983	275
CDK8	-594	-5509
CDK9	-1171	1524
CDKN1A	1646	-3540
CDKN1B	-2723	-862
CDKN2A	-1595	-4511
CEBPB	3564	-5089
CENPJ	-4330	-838
CHD3	-3413	422
CHD4	-1351	-4634
CHEK1	-741	-211
CHEK2	-1302	-2709
CITED2	2659	-104
CITED4	3463	-701
CNOT1	-1273	-4543
CNOT10	-811	-361
CNOT11	663	-2236
CNOT3	2042	565
CNOT4	-399	-3064
CNOT6	1783	-3728
CNOT6L	-4229	-5686
CNOT7	-1154	349
CNOT8	3701	-2054
COX11	-4412	-789
COX14	-471	-3835
COX16	34	-1160
COX19	-2178	-4047
COX20	-1527	-4841
COX4I1	1484	-5506
COX5A	2495	-2944
COX5B	2517	382
COX6A1	1930	-961
COX6B1	2224	-2634
COX6C	220	-1411
COX7A2L	3386	-2476
COX7C	176	-4071
COX8A	2745	-1258
CRADD	1987	-4017
CREB1	-430	-672
CREBBP	1153	-5804
CSNK2A2	2614	-4422
CSNK2B	1389	-998
CTDP1	2503	1112
CTLA4	-3751	2506
CTNNB1	2626	-1691
CTSL	1504	-6671
CTSV	-910	-5834
CUL1	-4281	-5146
CYCS	-411	-3927
DAXX	-3855	-450
DDB2	-4408	-561
DDIT3	1831	-3177
DDIT4	-717	-2588
DEK	853	1060
DGCR8	-4568	-495
DNA2	-865	-2087
DPY30	1300	-1010
DYRK2	-4569	-3036
E2F1	2589	-1005
E2F4	2567	-172
E2F5	-2887	-2646
E2F6	-1514	-2466
E2F7	-1774	-1622
E2F8	918	-4363
EED	-3235	-1174
EHMT1	-2937	-1697
EHMT2	-2883	-1059
ELF1	505	-1733
ELF2	834	-3373
ELL	1886	574
EP300	2471	-4509
EPC1	-3513	-2797
ERBB2	-4865	-5145
ERCC2	1210	-594
ERCC3	-2534	969
ESR2	-3194	-2661
ESRRA	2372	-2927
EXO1	-488	-3123
EZH2	-3415	-20
FANCC	-4417	-3902
FANCD2	-4343	1778
FANCI	-4640	-4622
FAS	1281	-5824
FBXO32	-3875	-1875
FBXW7	-2055	-5428
FKBP5	4199	-5653
FOS	2120	2149
FOXO1	-3290	-5036
FOXO3	3966	711
FZR1	-670	-758
GADD45A	4195	-2249
GATA3	-4799	1861
GATAD2A	999	-256
GATAD2B	-535	-2871
GLS	-4610	-4781
GPAM	-3683	-4630
GPI	2558	-2211
GPS2	-293	-857
GSK3B	2756	736
GSR	4276	-4724
GTF2F1	1854	-1723
GTF2F2	2104	-2885
GTF2H3	-672	1025
GTF2H4	-876	-2761
GTF2H5	1345	691
HDAC1	184	-1016
HDAC10	721	-1304
HDAC11	1771	-3595
HDAC2	2129	-46
HDAC3	1727	-3771
HDAC4	4126	-3817
HDAC5	1746	-3144
HDAC7	2465	-4900
HEY2	-3420	2330
HIPK1	2325	-974
HIPK2	2441	-1520
HIVEP3	-843	2288
HSPD1	-562	-2021
HUS1	-45	-522
IL2RA	-2295	-6462
ING2	1603	-2115
ING5	-3565	-763
ITCH	407	-1366
ITGA4	-4122	1419
ITGA5	3349	-6767
ITGAL	-4012	2268
JMY	-4372	-4364
JUN	1286	69
JUNB	2850	-3031
KAT2A	-3970	-5050
KAT2B	-722	-1588
KAT5	405	-650
KCTD1	-569	-6296
KCTD6	1579	886
KMT2A	-3942	2484
KMT2C	17	-6379
KMT2D	1057	-6199
KMT2E	-1879	2390
KRAS	1276	440
L3MBTL2	-3969	-4114
LAMTOR1	4371	-5950
LAMTOR2	3287	1882
LAMTOR3	3292	321
LAMTOR4	1619	-6150
LAMTOR5	3865	-5095
LBR	3631	-3506
LDB1	-3712	1270
LMO2	3746	-5492
LRPPRC	-3590	-5728
MAF	-3821	-4350
MAML1	2088	-5348
MAML2	-189	-2078
MAML3	4123	-4054
MAP2K6	4082	-1130
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPKAP1	1911	1057
MAX	1511	-3235
MBD3	-170	1673
MDC1	-4716	-902
MDM2	1551	-1318
MDM4	-385	-2440
MEAF6	-2677	-3609
MED1	-1206	-2271
MED10	-2893	-2572
MED13	807	590
MED15	-3434	2114
MED16	2024	1719
MED17	1004	-1418
MED20	2814	-542
MED23	-2139	633
MED24	-2380	-2701
MED25	2518	-1286
MED26	1589	18
MED27	-3167	-960
MED30	-1669	491
MED31	447	445
MED4	1062	-4472
MED6	-279	560
MED7	62	778
MED8	3267	1289
MEN1	-2877	-2311
MGA	-3528	-3489
MLST8	117	287
MNAT1	-2935	311
MOV10	-4681	-6449
MSH2	-4382	83
MTA2	-2350	1649
MTOR	-3429	-1813
MYB	88	1502
NBN	717	750
NCOR1	2341	-3738
NCOR2	3557	-4281
NDRG1	1712	149
NDUFA4	2661	288
NEDD4L	3485	-5066
NELFA	-1157	35
NELFB	115	1822
NELFCD	-1954	2444
NELFE	1342	1377
NFATC2	-4851	2414
NFE2	4380	-6723
NFYA	1189	1464
NFYB	-3536	-531
NFYC	3345	-3078
NOP2	-3530	-2438
NOTCH1	1743	1722
NOTCH4	-1593	-6455
NR1D1	-3070	1187
NR1D2	-3728	663
NR1H2	3207	-1471
NR1H3	-1069	-2305
NR1I2	-1321	-4903
NR2C1	-3506	-1463
NR2C2	-2910	119
NR2C2AP	-4442	-4688
NR3C1	162	-2420
NR3C2	-3885	324
NR4A1	-2128	657
NR4A2	-490	1416
NR4A3	-1547	954
NR6A1	3895	-5344
NRBP1	895	-1365
PARP1	-4548	-5521
PBRM1	2173	2290
PCBP4	-4128	-1359
PCGF5	-989	-3951
PCGF6	-222	-3963
PCNA	-1833	-511
PDPK1	2474	167
PHC1	-2820	-5180
PHC2	4171	1830
PHC3	-2698	1805
PHF20	-579	904
PIDD1	-2076	-6641
PIN1	-955	-1656
PINK1	4113	-3597
PIP4K2A	-707	1772
PIP4K2B	-2535	-6347
PIP4K2C	-4309	-5573
PLAGL1	139	1666
PLK2	-827	-6257
PLK3	2787	1597
PMAIP1	-4091	-2202
PML	-2938	549
PMS2	-1678	1574
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
PPARD	-1990	660
PPARGC1B	-1534	1840
PPM1A	3687	-3764
PPM1D	3444	-4316
PPP1R13B	-4473	1874
PPP1R13L	125	328
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5C	-4242	2376
PRDM1	-3015	799
PRDX1	2981	-877
PRDX2	1157	-5158
PRDX5	3882	-1661
PRKAA1	409	227
PRKAB1	401	-3297
PRKAB2	-2709	-1428
PRKACA	4378	-6032
PRKAG1	2126	-5980
PRKAG2	636	-5033
PRKCB	3029	-4518
PRKCQ	-4762	1372
PRMT1	-3186	-740
PRMT5	1232	-2112
PRR5	-4676	-1591
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTEN	3844	-1100
PTPN1	2254	2074
PTPN11	2038	-2302
PTPN4	-4818	-3156
RABGGTA	-734	1696
RABGGTB	-1597	2306
RAD1	-4807	1965
RAD17	-3716	-1101
RAD50	-2373	2067
RAD51	-835	-696
RAD51D	-4336	-710
RAD9A	-4349	-403
RAD9B	1008	-6145
RARA	2642	-5249
RARG	-1567	-5402
RB1	3985	-4740
RBBP4	-565	-3282
RBBP5	328	-779
RBBP8	-1554	-5854
RBL1	-3533	-3466
RBL2	-2519	-4497
RBM14	-2431	398
RBPJ	4017	-1118
RBX1	1368	-3241
RELA	-542	2085
RFC2	1853	-1206
RFC3	-3815	-803
RFC4	-3929	624
RFC5	-4518	-4946
RFFL	-515	-5968
RGCC	-2550	2408
RHEB	3356	-2334
RHNO1	-2003	-2816
RICTOR	-3383	1651
RING1	-1216	-1490
RMI2	-1212	1934
RNF111	2267	779
RNF2	1192	-1936
RNF34	-1902	42
RORA	-4672	2287
RPA1	-4688	-2495
RPA3	-3040	-1890
RPS27A	-2201	-2138
RPTOR	-3804	2134
RRAGA	2539	-1657
RRAGC	1856	-2585
RRAGD	4008	-6311
RRM2	-62	-574
RRM2B	2842	-5757
RUNX1	3262	-4082
RUNX2	-4180	-5055
RUNX3	-4885	2402
RYBP	2154	1520
SATB2	2834	-6456
SCMH1	-1799	1397
SCO1	-3455	-1715
SCO2	-1303	-4657
SESN1	-3059	-3887
SESN2	1099	-3423
SESN3	-1054	1141
SETD1A	-1763	-2070
SETD1B	231	-5034
SETD9	-389	-6605
SFN	500	-5994
SGK1	1689	-6076
SIN3A	-3818	-4151
SIN3B	-1256	570
SIRT1	-1254	-1775
SIRT3	-3016	-1430
SKI	-4153	-2431
SKIL	-234	-3633
SKP1	1536	-2290
SKP2	-2759	-1566
SLC2A3	4160	-4757
SLC38A9	906	-3360
SMAD1	3872	-3272
SMAD2	1830	-1994
SMAD3	-4538	-4628
SMAD4	-2796	-6535
SMAD6	3456	-3209
SMAD7	-4617	-4450
SMARCA2	-821	296
SMARCA4	1758	2317
SMARCB1	-1149	-714
SMARCC1	-3025	1327
SMARCC2	-1236	-3828
SMARCD1	-4499	-2643
SMARCD2	2918	967
SMARCE1	-1290	-3418
SMURF1	-780	1321
SMURF2	-3735	-3048
SMYD2	-3787	-3757
SNW1	1979	946
SOCS3	4399	2178
SOCS4	-1512	-1919
SOD2	1587	573
SP1	3686	-3141
SPI1	4085	-6766
SRC	-2999	-4427
SREBF1	2701	-4015
SSRP1	-4179	-2441
STAT1	-4529	2195
STK11	723	-5709
STUB1	-330	-2168
SUMO1	2903	-3986
SUPT16H	-4301	-3702
SUPT4H1	930	-1899
SUPT5H	-2108	-3641
SURF1	1204	-4976
TACO1	1600	-5534
TAF10	3039	1606
TAF11	-881	-719
TAF12	3552	-1765
TAF13	3098	-908
TAF15	-2008	-3109
TAF2	-1828	-4149
TAF3	-559	-3002
TAF4	-516	-6161
TAF4B	-2666	-1647
TAF5	-1350	1150
TAF6	-2367	1804
TAF7	673	-3426
TAF9	388	1714
TBL1XR1	1669	962
TCEA1	-309	-4211
TCF12	-386	-4702
TCF3	-2318	-6049
TCF7	-3643	2023
TCF7L2	-1917	-3431
TFAP2E	-1949	-6087
TFDP1	3849	-1587
TFDP2	-4891	-4793
TGFA	4083	-3020
TGFB1	1959	-6
TGIF1	-2933	-5815
TGIF2	-3603	-6609
THRA	-1986	-2798
TIGAR	2514	-1893
TMEM219	1336	-6062
TNFRSF10A	561	-3935
TNFRSF10B	3754	1433
TNFRSF10D	4189	-5911
TNKS1BP1	-1672	-5457
TNRC6A	-1710	-5420
TNRC6B	-1353	2270
TOP3A	3549	-3594
TOPBP1	-1033	180
TP53	-4034	-739
TP53BP2	2152	-5830
TP53I3	4139	-6077
TP53INP1	2660	-2058
TP53RK	-4708	-2342
TPX2	479	-4637
TRIAP1	82	-3808
TRIM28	-1538	1191
TRIM33	-3001	-2091
TSC1	-638	1527
TSC2	-262	895
TTC5	-795	-1440
TXN	3732	284
TXNIP	-3347	-2777
TXNRD1	3685	-4647
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2C	1933	1091
UBE2D1	4255	-1581
UBE2D3	3944	-373
UBE2E1	2822	-5882
UBE2I	-245	233
UBE2S	1766	2449
USP7	2576	-2216
VDR	3768	-3651
VEGFA	3235	-2723
WDR5	39	-5613
WRN	-4713	-2102
WWOX	-4138	1732
WWP1	-3604	-1865
YAF2	-2375	-3920
YEATS4	-1167	1953
YES1	-4772	-4415
YWHAB	2611	2125
YWHAE	4173	-4168
YWHAG	4294	-5545
YWHAH	3949	-2902
YWHAQ	-2362	-2908
YWHAZ	2200	541
YY1	169	-5165
ZFHX3	3213	-2025
ZFP1	-3852	-2240
ZFP14	-3635	1678
ZFP28	-2155	-6320
ZFP30	-4185	-366
ZFP37	-2868	-5928
ZFP90	-3354	824
ZFPM1	-3657	2378
ZIK1	-4120	2035
ZKSCAN1	679	-3843
ZKSCAN3	-2686	-5530
ZKSCAN4	-1570	-5770
ZKSCAN5	413	468
ZKSCAN8	-4228	-6728
ZNF10	-4018	-1897
ZNF101	-1711	2155
ZNF136	-4348	-3471
ZNF138	-4303	-5255
ZNF14	-4209	-4397
ZNF140	-2969	-2581
ZNF141	-3147	-526
ZNF155	-1525	-4127
ZNF160	-3076	-2923
ZNF169	-1933	-737
ZNF17	-3236	-1485
ZNF175	-2613	-5289
ZNF18	-763	-3535
ZNF180	-3911	-2110
ZNF184	-4134	-1046
ZNF189	1184	2001
ZNF19	-4117	907
ZNF2	-2490	-5367
ZNF20	1739	-4807
ZNF200	-49	-1750
ZNF202	-4295	1338
ZNF211	-4299	-6023
ZNF212	-3620	620
ZNF213	2377	-1128
ZNF215	-1104	-2720
ZNF221	-932	-6268
ZNF222	-27	-1983
ZNF223	-2186	-6465
ZNF224	-3540	-2768
ZNF226	-4079	-3429
ZNF227	-3454	-1334
ZNF23	-3922	-3592
ZNF233	-1172	-4234
ZNF234	-2858	-5598
ZNF235	-4402	-5194
ZNF248	-4224	-3321
ZNF25	-1662	-5487
ZNF250	-4622	554
ZNF253	-3902	-1053
ZNF257	-3934	-3813
ZNF26	-3503	-3960
ZNF264	-2391	-4068
ZNF268	-2180	-5808
ZNF274	-2926	-5798
ZNF282	1823	-5468
ZNF286A	-4566	-2915
ZNF287	-4785	-5090
ZNF3	-4783	-1141
ZNF302	-4002	659
ZNF311	-3401	-5855
ZNF324	-3485	-3484
ZNF324B	-4083	651
ZNF331	-2940	-2081
ZNF333	1406	-2425
ZNF337	-4450	-3809
ZNF33A	-2069	157
ZNF33B	-4633	-2030
ZNF34	-1702	-964
ZNF343	-4192	-4524
ZNF354A	1349	-4473
ZNF354C	-4210	-6378
ZNF382	-2513	-4717
ZNF394	408	-628
ZNF398	-1801	155
ZNF417	-1650	-2829
ZNF418	-2453	-6578
ZNF419	-4356	-5268
ZNF420	-3816	-3752
ZNF425	-2185	-4710
ZNF426	-1310	-3104
ZNF43	-4578	-5370
ZNF430	-1468	-4879
ZNF431	-3368	-5647
ZNF432	-4068	-5374
ZNF436	-3527	-5576
ZNF440	-2954	-5938
ZNF443	-1565	-4894
ZNF445	1111	-5606
ZNF446	-3697	-3030
ZNF461	-4655	-2540
ZNF468	-519	-4348
ZNF470	-3363	-6469
ZNF480	-2012	-4983
ZNF483	-3488	-5903
ZNF484	-3318	-304
ZNF490	-788	-2501
ZNF492	-1392	-6580
ZNF496	-4377	-3057
ZNF500	-4575	1026
ZNF506	-3274	-4344
ZNF517	-4437	-228
ZNF528	-4227	-6459
ZNF529	-3806	-3659
ZNF530	-4722	-6175
ZNF540	-4146	-4576
ZNF546	-1454	-1610
ZNF547	-1616	-4822
ZNF549	-4632	-5587
ZNF550	-4164	-5905
ZNF552	1735	-5023
ZNF554	-4479	-1275
ZNF559	-2851	-4261
ZNF561	-1281	-2945
ZNF563	-3853	-5992
ZNF564	-1354	-2468
ZNF566	-4380	-939
ZNF567	-3075	-5136
ZNF568	-4485	-6314
ZNF569	-4403	-352
ZNF570	-4429	-4872
ZNF571	-4564	-5324
ZNF573	-3474	-3023
ZNF582	-3463	-6112
ZNF583	-3403	-4848
ZNF584	-4162	-5742
ZNF585A	-2547	-4862
ZNF585B	-3869	-2710
ZNF587	-52	-1759
ZNF589	-1680	1425
ZNF596	-3483	-6669
ZNF597	-3369	-4633
ZNF600	-4273	-5453
ZNF605	-773	-1335
ZNF606	-3225	-5401
ZNF610	-1916	-6042
ZNF611	-1413	-5441
ZNF613	615	-5448
ZNF614	-3337	-2566
ZNF615	-1623	-5583
ZNF619	-2957	-6317
ZNF620	-4534	-5485
ZNF621	-4107	-3523
ZNF624	-982	-3879
ZNF627	-328	-2790
ZNF641	-2580	-5851
ZNF655	-1035	-2976
ZNF664	-3459	1571
ZNF665	-2634	-6565
ZNF668	1289	1462
ZNF670	-920	-5736
ZNF671	-2540	-680
ZNF677	-3143	-6476
ZNF678	-4108	530
ZNF681	-3034	-3353
ZNF684	-3341	-2033
ZNF688	-2575	-4023
ZNF689	-3330	-4943
ZNF691	-2067	-4147
ZNF692	-1428	-1190
ZNF696	-4504	-3058
ZNF70	-4592	-5340
ZNF700	-1424	-3707
ZNF701	-1059	-6116
ZNF703	-4045	-4320
ZNF706	-1867	-5848
ZNF707	-4368	-4401
ZNF708	-3475	-2881
ZNF709	-3111	-6445
ZNF710	2909	-6541
ZNF713	-1734	-3012
ZNF714	-985	-2480
ZNF717	-2945	-5768
ZNF736	-4506	-4463
ZNF737	-3596	-6022
ZNF74	-4690	-2918
ZNF740	-4355	878
ZNF746	3291	-3816
ZNF747	1377	-451
ZNF749	-3798	-5865
ZNF75A	-2525	-1824
ZNF761	-1788	-3885
ZNF764	-2191	-913
ZNF77	-4137	-489
ZNF771	-2493	-3926
ZNF772	-747	-5966
ZNF774	1767	-1078
ZNF775	1904	-4991
ZNF776	110	-3870
ZNF777	-2229	-4823
ZNF778	-3708	1050
ZNF782	-3127	128
ZNF785	-2244	-5042
ZNF786	-2189	56
ZNF79	-2977	470
ZNF790	-3832	-6139
ZNF791	-2443	-5116
ZNF792	-3008	645
ZNF793	-3375	-6557
ZNF799	-3666	-6025
ZNF839	-659	-6246
ZNF92	-3740	-2695
ZSCAN25	-3311	2482

---

---

Transport of small molecules

Transport of small molecules

metric	value
setSize	342
pMANOVA	1.21e-09
p.adjustMANOVA	7.04e-08
s.dist	0.205
s.RNA	0.204
s.meth	-0.0204
p.RNA	1.48e-10
p.meth	0.522

Top 20 genes

Gene	RNA	meth
TRPM2	4205	-6600
FBXL5	4370	-6189
PRKACA	4378	-6032
ATP6V0A1	4375	-5877
SLCO3A1	3763	-6618
SLC16A3	4026	-6120
MCU	4330	-5524
SLC8B1	3408	-6691
NCEH1	4100	-5550
SLC24A4	3432	-6556
SLC6A6	4092	-5316
ATP11A	3801	-5671
ASPH	4365	-4906
CYB5R4	3820	-5486
SGK3	3339	-6274
ATP6V0C	4218	-4697
SLC2A3	4160	-4757
SLC39A1	3999	-4836
CLTA	3788	-5077
TTYH3	3047	-6290

Click HERE to show all gene set members

All member genes

	RNA	meth
ABCA1	2459	-6487
ABCA2	-3762	-5284
ABCA5	-2932	-6277
ABCA7	1000	-4798
ABCB10	2408	-1135
ABCB6	2624	-6503
ABCB8	-353	-1633
ABCB9	-668	-3335
ABCC1	179	-871
ABCC10	-1495	-2526
ABCC4	3217	-3153
ABCC5	794	-2379
ABCD2	-4177	553
ABCD3	1847	-2453
ABCF1	-3323	744
ABCG1	-2617	2179
ACO1	-2845	-377
ADCY4	2020	-6389
ADCY7	-980	-5596
ADCY9	33	-2618
ADD1	2243	-89
ADD3	1290	2319
AFG3L2	-3989	-123
AHCYL2	129	-1769
AKAP1	-4353	-1116
ALAD	3874	-1369
ANKH	-4621	2518
ANO10	4288	1059
ANO6	3597	-3634
ANO7	-720	-5223
ANO8	2454	384
AP2A1	2869	-4887
AP2M1	3936	20
AP2S1	3581	-3262
APOBR	3169	-5309
AQP11	-711	-5302
AQP3	-3422	2187
ARL2	-183	-4526
ARL2BP	-2117	-2225
ASIC1	-1022	-226
ASPH	4365	-4906
ATP10A	-4817	2183
ATP10D	777	-5501
ATP11A	3801	-5671
ATP11B	2429	1806
ATP13A1	-1684	1912
ATP13A2	1051	-4240
ATP1A1	910	-365
ATP1A3	-4414	-462
ATP1B1	-3130	111
ATP1B3	-416	1223
ATP2A1	-1409	-4587
ATP2A2	3591	1489
ATP2A3	-299	1190
ATP2B4	-1530	1124
ATP2C1	1813	-1842
ATP6V0A1	4375	-5877
ATP6V0A2	-4811	689
ATP6V0B	3921	1604
ATP6V0C	4218	-4697
ATP6V0D1	4282	-1003
ATP6V0E1	3919	-2865
ATP6V0E2	-4420	-6625
ATP6V1A	4318	1580
ATP6V1B2	4178	-4232
ATP6V1C1	3887	655
ATP6V1D	4174	-1234
ATP6V1E1	3588	-3948
ATP6V1F	2338	1350
ATP6V1G2	-3312	-3714
ATP6V1H	3607	-1695
ATP7B	2844	-5085
ATP8A1	-4599	-250
ATP8B2	-3991	-5387
ATP8B3	1747	-2683
ATP8B4	2945	1090
ATP9B	2196	735
BEST4	-2953	-547
BMP1	77	2278
BSG	4245	-1562
CALM1	-626	-5019
CAMK2D	-4581	-2867
CAMK2G	601	2354
CAND1	-2041	-421
CLCN2	-269	1337
CLCN3	3125	-401
CLCN6	703	-775
CLCN7	611	-5887
CLTA	3788	-5077
CLTC	4149	2477
CTNS	2858	-4816
CUL1	-4281	-5146
CUTC	1373	1120
CYB5R1	4394	-1352
CYB5R4	3820	-5486
CYB5RL	-3965	-1109
CYBRD1	2220	-6417
DERL1	-3060	123
DERL2	987	-2287
DERL3	-2415	-2550
EIF2S1	1532	-4266
EIF2S2	2500	-783
EMB	3100	1670
ERLEC1	217	-2711
ERLIN1	4076	899
ERLIN2	4104	-4042
FBXL5	4370	-6189
FLVCR1	-2770	-1280
FTH1	1827	-521
FTL	3957	-4621
FURIN	4191	2351
FXYD7	-2325	-6745
GLRX3	-466	1234
GNAS	3508	951
GNB1	3736	-2920
GNB2	3650	-309
GNB4	3163	-6007
GNB5	163	1821
GNG2	-2538	-3847
GNG3	285	2231
GNG4	-649	2073
GNG5	4043	1920
GNG7	-1581	-4773
GNGT2	-4735	2438
HDLBP	3376	-4537
HMOX2	-4583	2130
IREB2	2000	-265
KCNJ11	-1226	-2105
LDLR	2505	-494
LDLRAP1	-3226	643
LETM1	-1375	-460
LIPA	2686	587
LIPG	-325	-3956
LMF1	-3149	-2880
LMF2	-2644	-4777
LRRC8A	-2689	1064
LRRC8B	1037	-4353
LRRC8C	186	-3147
LRRC8D	1880	961
LSR	-2353	-5404
MBTPS1	955	-398
MCOLN1	3404	-5518
MCOLN2	-4474	2341
MCU	4330	-5524
MICU1	4398	2147
MICU2	-272	-4379
MRS2	-2065	-800
MYLIP	-1191	-681
NCEH1	4100	-5550
NEDD4L	3485	-5066
NEDD8	2677	-1600
NIPA1	-4270	-4370
NIPA2	1490	-3037
NIPAL1	1112	-6467
NIPAL2	556	-6187
NIPAL3	-3722	-814
NPC1	-4816	-4304
NPC2	2118	-712
NR1H2	3207	-1471
NR1H3	-1069	-2305
OS9	4087	-975
OSTM1	2987	-1606
P4HB	3831	-1549
PARL	4124	-3904
PCSK5	1812	-4883
PEX19	2268	481
PEX3	-4732	392
PHB	-894	-3178
PHB2	-54	-473
PMPCB	-261	-766
PRKACA	4378	-6032
PRKACB	-4656	455
PRKAR1A	3924	-201
PRKAR1B	3514	731
PRKAR2A	2493	-4298
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
RAB11A	3969	-2965
RAF1	3488	-314
RNF185	2681	-2775
RNF5	-1999	-4625
RPS27A	-2201	-2138
RUNX1	3262	-4082
SAR1B	2676	489
SCARB1	2382	-4202
SCNN1A	-75	-6367
SEL1L	2877	-2307
SGK1	1689	-6076
SGK3	3339	-6274
SKP1	1536	-2290
SLC11A1	4243	-4413
SLC11A2	74	-4073
SLC12A2	-4292	-4207
SLC12A6	3627	-2521
SLC12A7	-724	-6698
SLC15A4	1288	-5940
SLC16A1	1626	576
SLC16A10	-1427	-2787
SLC16A3	4026	-6120
SLC16A7	1924	-2358
SLC17A5	1875	-3631
SLC1A4	-4188	-3680
SLC1A5	2673	-1807
SLC20A1	-4339	1152
SLC20A2	-4587	-345
SLC22A15	4068	2469
SLC22A4	4215	-1323
SLC22A5	2925	-5659
SLC24A4	3432	-6556
SLC25A22	-2040	-1050
SLC25A29	825	-595
SLC25A4	-4606	-2062
SLC26A11	-2392	-1718
SLC26A2	-873	-2627
SLC26A6	3555	-3638
SLC27A1	3744	-3528
SLC27A4	795	-6752
SLC29A1	436	-833
SLC29A2	-3408	-2510
SLC29A3	1977	2162
SLC29A4	-742	-5648
SLC2A1	-4221	1930
SLC2A11	-2232	-6205
SLC2A13	962	-5601
SLC2A3	4160	-4757
SLC2A9	2871	-6223
SLC30A1	3550	-4036
SLC30A5	-733	-2119
SLC30A6	-2	-1069
SLC30A7	-1328	-2297
SLC31A1	4077	-2303
SLC33A1	-644	-2395
SLC35A1	3104	-4021
SLC35A3	-3219	-4409
SLC35B2	-3671	-2200
SLC35B3	2161	-554
SLC35B4	1177	-2370
SLC35C1	880	-5366
SLC35D1	-2187	-2789
SLC36A1	4311	-1368
SLC36A4	3346	-4355
SLC38A1	-4338	842
SLC38A2	2566	-3406
SLC39A1	3999	-4836
SLC39A10	-3715	-3874
SLC39A14	-2166	-6123
SLC39A3	1644	-5691
SLC39A4	1630	494
SLC39A6	-2507	-2106
SLC39A8	3764	-4048
SLC3A2	1993	-1667
SLC41A1	-4392	-768
SLC43A1	-1388	-1502
SLC43A2	3632	-4400
SLC44A1	3877	2368
SLC44A2	861	2003
SLC4A2	3229	-243
SLC4A7	-4636	1208
SLC50A1	1271	-6179
SLC5A3	-4194	348
SLC5A5	-1625	-5772
SLC5A6	-1717	-2437
SLC5A9	1844	888
SLC6A6	4092	-5316
SLC6A9	3228	1503
SLC7A1	-2018	754
SLC7A11	-1753	-6233
SLC7A5	976	-6143
SLC7A6	-2098	-2873
SLC8A3	593	-5398
SLC8B1	3408	-6691
SLC9A1	3546	-753
SLC9A3	-2793	1428
SLC9A5	-2541	-6072
SLC9A8	1881	-4550
SLC9B1	-1880	1374
SLC9B2	-4300	-5310
SLCO3A1	3763	-6618
SLCO4A1	1900	-3333
SLCO4C1	1061	-1063
SMDT1	71	2068
SOAT1	3704	-4815
SPG7	-3845	-221
SRI	2709	-1804
STOM	2795	-3877
STOML2	-1194	-3256
TCIRG1	3087	-5082
TFR2	-3439	-6238
TFRC	468	-273
TPCN1	1992	-4797
TPCN2	2817	-1923
TRPC1	-3412	-2704
TRPC4AP	392	-4086
TRPM2	4205	-6600
TRPM7	-2401	-548
TRPV2	-1661	-1200
TTYH2	-1330	-6374
TTYH3	3047	-6290
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
VCP	2902	-2411
VDAC1	1566	-3624
VDAC3	134	1058
WNK1	1995	1966
WWP1	-3604	-1865
YME1L1	2433	-1525

---

---

Infectious disease

Infectious disease

metric	value
setSize	530
pMANOVA	4.84e-09
p.adjustMANOVA	2.68e-07
s.dist	0.153
s.RNA	0.116
s.meth	0.0996
p.RNA	6.88e-06
p.meth	0.000115

Top 20 genes

Gene	RNA	meth
CLTC	4149	2477
FURIN	4191	2351
ENTPD1	3775	2446
ANTXR2	3160	2471
GNG5	4043	1920
ACTG1	3901	1793
MYH9	2789	2182
MAPK1	3249	1865
BRD4	2344	2511
BRK1	2983	1970
DAD1	2346	2452
PSMA7	3028	1752
PSMD1	3112	1660
TAF10	3039	1606
CHMP1A	2269	2118
CBL	3241	1456
CORO1A	1967	2237
PSME3	3715	1116
VPS25	3332	1235
NUP214	3517	1119

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
ABI1	3018	-1788
ABI2	-4048	-5451
ABL1	63	-4891
ACTB	4156	-4515
ACTG1	3901	1793
ACTR2	3481	-3374
ACTR3	3448	-2917
ADAM17	3634	774
ADCY4	2020	-6389
ADCY7	-980	-5596
ADCY9	33	-2618
ADM	4359	-6151
ADORA2A	1094	-5935
ADRB2	-4624	-3531
AHCYL1	2658	-3553
ANTXR2	3160	2471
AP1B1	3995	-463
AP1G1	1397	516
AP1M1	2798	-2408
AP1S3	-1681	-5455
AP2A1	2869	-4887
AP2M1	3936	20
AP2S1	3581	-3262
ARF1	4184	-6686
ARID4A	1303	-5475
ARID4B	-13	-1226
ARPC1B	4291	-2022
ARPC2	3191	-3647
ARPC3	3729	-3767
ARPC5	3968	-3837
ATP1A1	910	-365
ATP1A3	-4414	-462
ATP1B1	-3130	111
ATP1B3	-416	1223
ATP6V1H	3607	-1695
B2M	-2195	-2389
BAIAP2	-72	1977
BANF1	-1439	-709
BECN1	2690	459
BRD4	2344	2511
BRK1	2983	1970
BRMS1	2116	800
BTRC	-1493	-2427
C3AR1	3573	-6729
CALM1	-626	-5019
CALR	2586	-3753
CANX	2151	-4839
CASP1	1501	-1448
CBL	3241	1456
CBX1	1770	-1720
CCNH	243	-3754
CCNK	923	-6142
CCNT1	-3292	1773
CD247	-4880	2098
CD4	-1648	-6372
CDC42	3268	-2719
CDK7	1983	275
CDK9	-1171	1524
CEBPD	4044	-5142
CHD3	-3413	422
CHD4	-1351	-4634
CHMP1A	2269	2118
CHMP2A	4024	-297
CHMP2B	2250	-4000
CHMP3	3769	-2694
CHMP4A	763	458
CHMP4B	4075	-4297
CHMP5	1850	-2010
CHMP6	2138	-2539
CHMP7	-2991	-1608
CLTA	3788	-5077
CLTC	4149	2477
COMT	3725	-6677
CORO1A	1967	2237
CPSF4	-3261	134
CRBN	-1918	919
CREB1	-430	-672
CRK	4091	-4581
CTDP1	2503	1112
CTNNB1	2626	-1691
CTNND1	-2821	1566
CTSL	1504	-6671
CUL5	265	-3077
CXCR4	-19	-1660
CYBA	2922	1006
CYFIP1	4295	-6630
CYFIP2	-3754	2232
DAD1	2346	2452
DAXX	-3855	-450
DBP	-4352	-1027
DDX5	-3465	1288
DNAJC3	3828	-2353
DPEP2	-808	-6530
DUSP16	-2082	-2622
DUT	-1865	1287
DVL1	0	-4520
DVL2	-4172	-1356
DVL3	2219	-3704
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNLL1	2378	-3319
DYNLL2	-1189	214
EDEM2	3982	-3093
EED	-3235	-1174
EEF2	90	2127
EIF2AK2	-3128	-3645
ELL	1886	574
ELMO1	2547	-2714
ELMO2	1591	1326
ENO1	4084	-6654
ENTPD1	3775	2446
ENTPD5	-1913	-4305
EPS15	1457	-654
ERCC2	1210	-594
ERCC3	-2534	969
EZH2	-3415	-20
FAU	-124	-3862
FEN1	-3865	-56
FGR	3853	-5292
FKBP1A	4177	-4465
FKBP4	263	-4442
FURIN	4191	2351
FUT8	-3421	-2455
FXYD7	-2325	-6745
FYN	-4495	1957
FZD7	-2024	-3834
GANAB	-317	-3501
GATAD2A	999	-256
GATAD2B	-535	-2871
GGT1	4376	-6607
GIPR	-4745	-2380
GNAI2	3616	-1747
GNAI3	3536	-909
GNAS	3508	951
GNB1	3736	-2920
GNB2	3650	-309
GNB4	3163	-6007
GNB5	163	1821
GNG2	-2538	-3847
GNG3	285	2231
GNG4	-649	2073
GNG5	4043	1920
GNG7	-1581	-4773
GNGT2	-4735	2438
GPS2	-293	-857
GRB2	4320	-2295
GRSF1	1966	27
GSDMD	614	-3378
GSK3A	3415	-2192
GSK3B	2756	736
GTF2A1	865	271
GTF2A2	3006	-1036
GTF2B	1193	-3218
GTF2E2	2276	-184
GTF2F1	1854	-1723
GTF2F2	2104	-2885
GTF2H3	-672	1025
GTF2H4	-876	-2761
GTF2H5	1345	691
HBEGF	1889	-6428
HDAC1	184	-1016
HDAC2	2129	-46
HDAC3	1727	-3771
HGS	1647	2123
HLA-A	-771	-5991
HMG20B	1802	-3649
HMGA1	32	802
HNRNPK	3259	-2386
HRH2	4395	-6490
HSP90AA1	411	-781
HSP90AB1	-2171	-5745
HSPA1A	3613	-3825
IFNAR1	3813	-490
IFNAR2	2778	-3573
IFNGR1	4301	310
IFNGR2	4279	-6331
IL6R	3645	-6410
IMPDH1	4313	-750
IMPDH2	-3507	446
IPO5	-3864	1869
IRS1	533	-4060
ISG15	-4701	1894
ITGA4	-4122	1419
ITPR1	-2478	-3278
ITPR2	2315	-6107
ITPR3	-3717	-3427
JAK1	-4072	-1022
JAK2	857	-1751
JUN	1286	69
KDM1A	-3266	900
KPNA1	400	-2889
KPNA2	-2190	-874
KPNA3	295	-897
KPNA4	1858	1716
KPNA5	-4625	-572
KPNB1	776	-2176
LCK	-4596	2489
LIG1	-4124	-4259
LIG4	2040	-949
MAN1B1	-1477	2249
MAN2A1	-418	-4486
MAP2K1	4183	-698
MAP2K2	2840	-3962
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK8	-3265	6
MBD3	-170	1673
MGAT1	2546	1169
MGAT2	507	-1666
MGAT4A	-1741	-2254
MGAT4B	3961	-6439
MGAT5	-918	-5572
MNAT1	-2935	311
MOGS	-913	-2356
MTA2	-2350	1649
MTA3	-3267	-1740
MVB12A	3199	272
MYH9	2789	2182
MYO9B	2637	687
NCBP1	-1807	-3745
NCBP2	-3329	-4067
NCK1	-4361	-1408
NCKAP1L	3360	-6178
NCKIPSD	97	-4332
NCOR1	2341	-3738
NCOR2	3557	-4281
NDC1	-4789	-5228
NEDD4L	3485	-5066
NELFA	-1157	35
NELFB	115	1822
NELFCD	-1954	2444
NELFE	1342	1377
NFKB2	-367	388
NLRP3	4089	-6357
NMT1	1558	-3001
NMT2	-4704	1340
NOXA1	-1664	-5872
NR3C1	162	-2420
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
P2RX4	3328	174
PABPN1	-169	-3743
PACS1	-2857	-4252
PAK2	3682	-3961
PARP1	-4548	-5521
PARP10	-2818	2302
PARP14	-4614	864
PARP16	-4591	678
PARP4	1574	-715
PARP6	-1506	-3268
PARP8	-2825	-759
PARP9	-1314	1117
PDCD6IP	2695	-3917
PHF21A	4265	-3398
PIK3R4	-1215	-3425
PLCG1	-4158	-3541
PLCG2	1884	-2562
PLK2	-827	-6257
PML	-2938	549
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
POM121	-2766	-1787
POM121C	-2305	-4315
PPIA	-2133	490
PRKACA	4378	-6032
PRKACB	-4656	455
PRKAR1A	3924	-201
PRKAR1B	3514	731
PRKAR2A	2493	-4298
PRKCSH	1991	-3007
PSIP1	-3416	-4249
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PSTPIP1	3462	1135
PTGER2	448	-5853
PTGER4	-4508	1153
PTGES3	1450	-1810
PTK2	1629	920
PYCARD	3942	-6598
RAB5A	3035	-1686
RAB7A	4002	-5570
RAC1	4031	971
RAE1	1963	-39
RAN	-2142	1257
RANBP1	-3377	-2212
RANBP2	-273	-4704
RANGAP1	-4525	1644
RB1	3985	-4740
RBBP4	-565	-3282
RBX1	1368	-3241
RCC1	543	-1845
RCOR1	4190	-4864
RELA	-542	2085
REST	276	2128
RHBDF2	1487	-4959
RNF213	-4630	2228
RNGTT	1007	-2952
RNMT	-4139	2172
ROCK1	3246	-985
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPN1	3580	-2841
RPN2	3058	-688
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
S1PR1	-3180	2436
SAP18	1882	-3579
SAP30	3742	-2185
SAP30L	1978	-233
SEC13	2266	-3749
SEH1L	-1875	-1615
SFPQ	712	-1117
SH3GL1	3324	1075
SIGMAR1	-2514	306
SKP1	1536	-2290
SLC25A4	-4606	-2062
SNF8	2387	-2157
SRC	-2999	-4427
SSRP1	-4179	-2441
ST3GAL1	-2406	1767
ST3GAL2	3958	-2686
ST3GAL3	158	-1055
ST3GAL4	2285	-4996
ST6GAL1	-4715	1948
ST6GALNAC3	4221	145
ST6GALNAC4	-207	-5981
STAM	397	770
STAM2	2488	-2181
STAT2	-3894	-3295
STT3A	1442	-4222
STX1A	-1213	-2461
STX1B	-886	-6167
SUDS3	1652	-1851
SUGT1	475	594
SUMO1	2903	-3986
SUPT16H	-4301	-3702
SUPT4H1	930	-1899
SUPT5H	-2108	-3641
SYK	4192	-5054
TAF10	3039	1606
TAF11	-881	-719
TAF12	3552	-1765
TAF13	3098	-908
TAF15	-2008	-3109
TAF2	-1828	-4149
TAF3	-559	-3002
TAF4	-516	-6161
TAF4B	-2666	-1647
TAF5	-1350	1150
TAF6	-2367	1804
TAF7	673	-3426
TAF9	388	1714
TBK1	1067	-4616
TBL1XR1	1669	962
TCEA1	-309	-4211
TGFB1	1959	-6
TLR2	4206	-6586
TLR9	-1850	2292
TPR	-2242	-973
TRIM27	3651	-1744
TRIM28	-1538	1191
TSG101	3430	-5032
TUBB	-2209	1395
TXN	3732	284
TXNIP	-3347	-2777
TXNRD1	3685	-4647
TYK2	3021	-3105
UBA52	349	752
UBAP1	3980	-2481
UBB	2759	-1321
UBC	1618	-2568
UBE2I	-245	233
UVRAG	-3092	-3344
VAMP1	-2908	-1537
VAMP2	-4559	-2770
VAV1	3499	-3184
VAV2	-1214	-643
VAV3	1824	-6342
VCP	2902	-2411
VEGFA	3235	-2723
VHL	1262	1389
VIPR1	-1904	-3480
VPS25	3332	1235
VPS28	1488	-2471
VPS33B	-630	-2464
VPS36	-2165	-2008
VPS37A	2668	-3512
VPS37B	1356	-6110
VPS37C	3572	421
VPS4A	248	118
VTA1	2506	-3898
WASF1	4414	-1056
WASF2	3782	-2654
WASL	87	-4742
WIPF1	177	-4382
WIPF2	2249	-2523
XPO1	-371	-870
XRCC4	2821	-3706
XRCC5	2075	-3770
XRCC6	-1335	376
YES1	-4772	-4415
ZBP1	-4869	-410
ZCRB1	150	2291

---

---

Programmed Cell Death

Programmed Cell Death

metric	value
setSize	153
pMANOVA	1.12e-08
p.adjustMANOVA	5.78e-07
s.dist	0.281
s.RNA	0.279
s.meth	0.0326
p.RNA	2.99e-09
p.meth	0.489

Top 20 genes

Gene	RNA	meth
MAPK1	3249	1865
BCL2L11	3187	1781
YWHAB	2611	2125
TNFRSF10B	3754	1433
PSMA7	3028	1752
BCL2L1	3979	1306
PSMD1	3112	1660
PSME3	3715	1116
PSMD12	2710	1314
PSMB2	1439	2355
PSMD13	2376	1328
PSMA2	2052	1205
PRKCD	4154	584
BID	2410	844
PTK2	1629	920
CARD8	1753	794
YWHAZ	2200	541
PLEC	1704	385
CFLAR	3312	197
CHMP4A	763	458

Click HERE to show all gene set members

All member genes

	RNA	meth
ACIN1	275	-1699
ADD1	2243	-89
AKT1	1234	-1942
AKT2	133	-141
APAF1	4158	-2104
APC	1073	-4775
APPL1	101	28
ARHGAP10	-3012	2322
AVEN	-2690	1579
BAD	2904	-1382
BAK1	-105	-4022
BAX	2357	-3623
BBC3	-2571	-3845
BCL2	-1421	2361
BCL2L1	3979	1306
BCL2L11	3187	1781
BID	2410	844
BIRC2	1737	-1862
BIRC3	-4159	-2320
BMF	1582	-6386
C1QBP	-275	-2507
CARD8	1753	794
CASP1	1501	-1448
CASP3	-208	-2764
CASP4	2359	-5184
CASP6	-856	-4898
CASP7	13	-842
CASP8	-4285	387
CASP9	3366	-234
CDKN2A	-1595	-4511
CFLAR	3312	197
CHMP2A	4024	-297
CHMP2B	2250	-4000
CHMP3	3769	-2694
CHMP4A	763	458
CHMP4B	4075	-4297
CHMP6	2138	-2539
CHMP7	-2991	-1608
CLSPN	1244	-1524
CTNNB1	2626	-1691
CYCS	-411	-3927
DAPK2	3108	-2374
DAPK3	1648	-4978
DBNL	3411	-3713
DFFA	1130	-3179
DFFB	-2160	-4631
DIABLO	-1989	-5548
DNM1L	978	-5217
DYNLL1	2378	-3319
DYNLL2	-1189	214
E2F1	2589	-1005
FADD	2211	-6328
FAS	1281	-5824
FLOT1	4125	-5214
FLOT2	3815	-2231
FNTA	-1755	1499
GSDMD	614	-3378
HMGB1	-86	-1263
HMGB2	3960	-5133
HSP90AA1	411	-781
IRF1	-2866	1887
IRF2	2640	-2044
KPNA1	400	-2889
KPNB1	776	-2176
LMNA	1348	-6474
LMNB1	4342	-942
MAPK1	3249	1865
MAPK3	4121	-2448
MAPK8	-3265	6
MAPT	-1656	2342
MLKL	3151	-4557
NMT1	1558	-3001
OMA1	949	-5732
OPA1	876	-4730
PAK2	3682	-3961
PDCD6IP	2695	-3917
PELI1	2800	-3839
PLEC	1704	385
PMAIP1	-4091	-2202
PPP1R13B	-4473	1874
PPP3CC	-4761	1250
PPP3R1	3675	-3276
PRKCD	4154	584
PRKCQ	-4762	1372
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTK2	1629	920
RIPK3	1497	-370
ROCK1	3246	-985
RPS27A	-2201	-2138
SATB1	-2592	-1979
SDCBP	4324	-2535
SFN	500	-5994
SPTAN1	-4344	-1250
STAT3	3628	-3606
STK24	2680	-1640
STUB1	-330	-2168
TFDP1	3849	-1587
TFDP2	-4891	-4793
TICAM1	2569	-2136
TJP2	1460	-67
TNFRSF10A	561	-3935
TNFRSF10B	3754	1433
TNFSF10	1009	-2143
TP53	-4034	-739
TP53BP2	2152	-5830
TRADD	-179	-1481
TRAF2	-4539	-1442
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
VIM	4364	-2247
YWHAB	2611	2125
YWHAE	4173	-4168
YWHAG	4294	-5545
YWHAH	3949	-2902
YWHAQ	-2362	-2908
YWHAZ	2200	541

---

---

Cellular response to chemical stress

Cellular response to chemical stress

metric	value
setSize	116
pMANOVA	1.15e-08
p.adjustMANOVA	5.78e-07
s.dist	0.328
s.RNA	0.326
s.meth	-0.033
p.RNA	1.48e-09
p.meth	0.541

Top 20 genes

Gene	RNA	meth
NCF4	4298	-6732
NLRP3	4089	-6357
GPX1	4327	-5467
BLVRB	4360	-5026
GSR	4276	-4724
PSMD6	3465	-5488
ERO1A	4115	-4535
TXNRD2	3261	-5499
PSMD4	3806	-4683
TXNRD1	3685	-4647
PSMC1	2977	-5705
PSMB5	3630	-4604
CAT	4214	-3922
NCOR2	3557	-4281
PSMC6	2757	-5508
HM13	3644	-3925
PSMF1	2775	-4867
STAT3	3628	-3606
CSNK2A2	2614	-4422
PSMB6	2854	-3576

Click HERE to show all gene set members

All member genes

	RNA	meth
ABCC1	179	-871
ATOX1	1562	-5343
BACH1	4212	210
BLVRA	2273	1170
BLVRB	4360	-5026
CAT	4214	-3922
CCS	471	102
CHD9	-1380	-5791
COX11	-4412	-789
COX14	-471	-3835
COX16	34	-1160
COX19	-2178	-4047
COX20	-1527	-4841
COX4I1	1484	-5506
COX5A	2495	-2944
COX5B	2517	382
COX6A1	1930	-961
COX6B1	2224	-2634
COX6C	220	-1411
COX7A2L	3386	-2476
COX7C	176	-4071
COX8A	2745	-1258
CREBBP	1153	-5804
CSNK2A2	2614	-4422
CSNK2B	1389	-998
CUL1	-4281	-5146
CUL3	2861	2054
CYBA	2922	1006
CYCS	-411	-3927
ERO1A	4115	-4535
FBXL17	-1827	-2422
GPX1	4327	-5467
GSR	4276	-4724
GSTP1	35	-5415
HDAC3	1727	-3771
HM13	3644	-3925
HMOX2	-4583	2130
KEAP1	1826	-2872
LRPPRC	-3590	-5728
MAFK	288	-2942
MED1	-1206	-2271
NCF4	4298	-6732
NCOA2	343	1407
NCOA6	2280	-1860
NCOR1	2341	-3738
NCOR2	3557	-4281
NDUFA4	2661	288
NFE2L2	2808	-1441
NLRP3	4089	-6357
NUDT2	963	-2046
P4HB	3831	-1549
PRDX1	2981	-877
PRDX2	1157	-5158
PRDX3	4351	972
PRDX5	3882	-1661
PRDX6	4109	916
PRKCD	4154	584
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
RBX1	1368	-3241
RPS27A	-2201	-2138
SCO1	-3455	-1715
SCO2	-1303	-4657
SIN3A	-3818	-4151
SIN3B	-1256	570
SKP1	1536	-2290
SKP2	-2759	-1566
SOD1	-1475	-1019
SOD2	1587	573
STAT3	3628	-3606
SURF1	1204	-4976
TACO1	1600	-5534
TBL1XR1	1669	962
TXN	3732	284
TXN2	1714	-257
TXNIP	-3347	-2777
TXNRD1	3685	-4647
TXNRD2	3261	-5499
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568

---

---

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

metric	value
setSize	133
pMANOVA	1.35e-08
p.adjustMANOVA	6.55e-07
s.dist	0.297
s.RNA	0.291
s.meth	0.0625
p.RNA	8.09e-09
p.meth	0.215

Top 20 genes

Gene	RNA	meth
ACTN1	4201	2335
DGKG	3539	2259
GNG5	4043	1920
WDR1	2948	2364
MAPK1	3249	1865
RHOA	3753	1313
PTPN1	2254	2074
CALU	3497	1252
RAC1	4031	971
CFL1	3683	912
RHOG	3858	860
PRKCD	4154	584
PFN1	2119	833
CSK	1990	862
MANF	813	1947
PTK2	1629	920
YWHAZ	2200	541
RAP1A	3148	323
TLN1	3876	191
GNG3	285	2231

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2170	-3533
AAMP	-1084	-5298
ABCC4	3217	-3153
ABHD12	-3773	-129
ABHD6	-854	-284
ACTN1	4201	2335
ACTN4	1907	-2928
AKT1	1234	-1942
ALDOA	4285	-1349
ANXA5	3692	-2845
APBB1IP	4003	-5120
APLP2	4343	-3465
APP	4249	-5300
ARRB1	632	-6363
ARRB2	3860	-2243
BRPF3	-2062	-937
CALM1	-626	-5019
CALU	3497	1252
CAP1	3635	-553
CD63	4308	-1017
CDC37L1	-2853	1097
CDC42	3268	-2719
CFL1	3683	912
CHID1	909	-254
CRK	4091	-4581
CSK	1990	862
CYB5R1	4394	-1352
DAGLB	2303	-6635
DGKA	-2629	2375
DGKD	-162	546
DGKE	-4323	-953
DGKG	3539	2259
DGKH	-953	-6190
DGKQ	-2697	1446
DGKZ	-1742	-6294
ENDOD1	1124	-4107
FAM3C	-3576	527
FERMT3	4270	-1343
FYN	-4495	1957
GNA12	1128	-3386
GNA13	2310	-2285
GNA15	4391	-6690
GNAI2	3616	-1747
GNAI3	3536	-909
GNAQ	4145	-6733
GNB1	3736	-2920
GNB2	3650	-309
GNB4	3163	-6007
GNB5	163	1821
GNG2	-2538	-3847
GNG3	285	2231
GNG4	-649	2073
GNG5	4043	1920
GNG7	-1581	-4773
GNGT2	-4735	2438
GRB2	4320	-2295
GTPBP2	2582	-487
HABP4	-4052	230
ITPR1	-2478	-3278
ITPR2	2315	-6107
ITPR3	-3717	-3427
LCK	-4596	2489
LCP2	-363	1588
MANF	813	1947
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
NHLRC2	-2558	-716
OLA1	1835	-508
P2RY1	3468	-5377
PCYOX1L	-605	339
PDPK1	2474	167
PFN1	2119	833
PHACTR2	2092	-6672
PIK3CA	1703	-1445
PIK3CG	569	-2045
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R3	-4692	-22
PIK3R5	-688	514
PLCG2	1884	-2562
PLEK	633	-5891
PPIA	-2133	490
PRKCA	356	810
PRKCB	3029	-4518
PRKCD	4154	584
PRKCE	-2638	-5632
PRKCH	-4868	1376
PRKCQ	-4762	1372
PRKCZ	-4470	-5220
PSAP	3061	-4192
PTK2	1629	920
PTPN1	2254	2074
PTPN11	2038	-2302
PTPN6	2452	-4586
QSOX1	4315	-1087
RAC1	4031	971
RAC2	1962	-868
RAF1	3488	-314
RAP1A	3148	323
RAP1B	1058	-1031
RASGRP1	-4668	2119
RASGRP2	-2873	1508
RHOA	3753	1313
RHOB	390	-4992
RHOG	3858	860
SCCPDH	3431	-5477
SHC1	1472	-2954
SOD1	-1475	-1019
SOS1	-1748	-6775
SRC	-2999	-4427
SRGN	4011	-2722
STX4	189	-6001
STXBP2	4170	-6352
STXBP3	3212	-1306
SYK	4192	-5054
TAGLN2	3178	-1136
TEX264	-2805	55
TGFB1	1959	-6
TGFB2	-2429	-6761
TGFB3	-2583	-5946
TLN1	3876	191
TMX3	-249	-6313
TOR4A	4072	-6704
TUBA4A	2678	-4571
VAV1	3499	-3184
VAV2	-1214	-643
VAV3	1824	-6342
VCL	3157	-5870
VEGFA	3235	-2723
VTI1B	4065	-359
WDR1	2948	2364
YWHAZ	2200	541

---

---

Cellular responses to external stimuli

Cellular responses to external stimuli

metric	value
setSize	457
pMANOVA	2.73e-08
p.adjustMANOVA	1.27e-06
s.dist	0.157
s.RNA	0.121
s.meth	0.0995
p.RNA	1.27e-05
p.meth	0.000328

Top 20 genes

Gene	RNA	meth
MAP4K4	3823	2014
PHC2	4171	1830
DNAJB6	3609	1923
ATP6V1A	4318	1580
ATP6V0B	3921	1604
LAMTOR2	3287	1882
MAPK1	3249	1865
BAG1	2618	2301
CUL3	2861	2054
PSMA7	3028	1752
PSMD1	3112	1660
CBX8	2112	2207
FOS	2120	2149
AGO1	2217	1997
UBE2S	1766	2449
PRDX3	4351	972
PSME3	3715	1116
ARNT	3596	1140
CSRP1	3453	1181
DNAJA2	2185	1824

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
ABCC1	179	-871
ACD	-2542	-5810
ACTR10	3309	-1291
ACTR1A	2965	-1
AGO1	2217	1997
AGO3	-324	-6442
AJUBA	-2602	-2301
AKT1S1	3477	-2319
ANAPC1	-4659	403
ANAPC10	-1520	-6111
ANAPC11	2490	344
ANAPC15	4132	-1379
ANAPC16	-640	-4507
ANAPC2	-2390	-1007
ANAPC4	-2075	-1696
ANAPC5	-4080	-2530
ANAPC7	-1573	1560
ARNT	3596	1140
ARNTL	-2150	-4129
ASNS	-2775	12
ATF3	-3386	-4121
ATF4	2535	-956
ATF5	-1618	-722
ATM	-4170	202
ATOX1	1562	-5343
ATP6V0B	3921	1604
ATP6V0C	4218	-4697
ATP6V0D1	4282	-1003
ATP6V0E1	3919	-2865
ATP6V0E2	-4420	-6625
ATP6V1A	4318	1580
ATP6V1B2	4178	-4232
ATP6V1C1	3887	655
ATP6V1D	4174	-1234
ATP6V1E1	3588	-3948
ATP6V1F	2338	1350
ATP6V1G2	-3312	-3714
ATP6V1H	3607	-1695
ATR	-3743	970
BACH1	4212	210
BAG1	2618	2301
BAG2	-2637	-2208
BAG3	-948	423
BAG4	3756	-3089
BAG5	-1481	-4477
BLVRA	2273	1170
BLVRB	4360	-5026
BMI1	-3460	-6383
C12orf66	-4076	-3658
CABIN1	-3863	-2517
CAMK2D	-4581	-2867
CAMK2G	601	2354
CAPZA1	3648	572
CAPZA2	3920	-36
CAPZB	3576	-4065
CAT	4214	-3922
CBX4	699	-5288
CBX6	1421	-3511
CBX8	2112	2207
CCAR2	-3633	2391
CCNA2	520	-1132
CCNE1	-4514	-3403
CCNE2	1953	-3396
CCS	471	102
CDC16	-1877	-4152
CDC23	-4259	-707
CDK2	-1522	1018
CDK4	-4235	-1295
CDK6	-2015	-2864
CDKN1A	1646	-3540
CDKN1B	-2723	-862
CDKN2A	-1595	-4511
CDKN2C	2853	-130
CDKN2D	3469	308
CEBPB	3564	-5089
CEBPG	2122	1702
CHD9	-1380	-5791
CITED2	2659	-104
CLOCK	-2411	-1159
COX11	-4412	-789
COX14	-471	-3835
COX16	34	-1160
COX19	-2178	-4047
COX20	-1527	-4841
COX4I1	1484	-5506
COX5A	2495	-2944
COX5B	2517	382
COX6A1	1930	-961
COX6B1	2224	-2634
COX6C	220	-1411
COX7A2L	3386	-2476
COX7C	176	-4071
COX8A	2745	-1258
CREB1	-430	-672
CREBBP	1153	-5804
CRTC1	-15	-728
CRTC2	26	1184
CRTC3	66	-3688
CSNK2A2	2614	-4422
CSNK2B	1389	-998
CSRP1	3453	1181
CUL1	-4281	-5146
CUL2	805	-1212
CUL3	2861	2054
CYBA	2922	1006
CYCS	-411	-3927
DCTN2	4235	-6011
DCTN3	2396	-4272
DCTN4	3796	-2073
DCTN5	-1222	-5100
DCTN6	3145	819
DDIT3	1831	-3177
DEDD2	1107	1927
DEPDC5	28	-4322
DNAJA1	2099	-1834
DNAJA2	2185	1824
DNAJA4	-291	2305
DNAJB1	-1737	-3687
DNAJB6	3609	1923
DNAJC2	-1507	-1772
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNLL1	2378	-3319
DYNLL2	-1189	214
E2F1	2589	-1005
E2F2	3922	386
E2F3	2768	-2884
EED	-3235	-1174
EEF1A1	-1549	720
EGLN1	2741	-6231
EGLN2	1221	-3619
EHMT1	-2937	-1697
EHMT2	-2883	-1059
EIF2AK1	3854	1012
EIF2AK4	11	-5466
EIF2S1	1532	-4266
EIF2S2	2500	-783
EP300	2471	-4509
EP400	-2038	1434
EPAS1	3494	535
ERF	1594	-683
ERO1A	4115	-4535
ETS1	-4320	2277
ETS2	3624	-5483
EZH2	-3415	-20
FAU	-124	-3862
FBXL17	-1827	-2422
FKBP4	263	-4442
FKBP5	4199	-5653
FLCN	1237	708
FNIP1	2191	355
FOS	2120	2149
FZR1	-670	-758
GCN1	-3759	-6714
GPX1	4327	-5467
GRB10	4386	-70
GSK3B	2756	736
GSR	4276	-4724
GSTP1	35	-5415
HDAC3	1727	-3771
HIF1A	3219	-3349
HIF1AN	-1348	-1051
HIGD1A	3194	-4744
HIRA	-3362	-860
HM13	3644	-3925
HMGA1	32	802
HMOX2	-4583	2130
HSBP1	3674	-3338
HSF1	2428	1452
HSP90AA1	411	-781
HSP90AB1	-2171	-5745
HSPA13	-364	-1732
HSPA14	-3248	866
HSPA1A	3613	-3825
HSPA1B	2669	-513
HSPA1L	1013	885
HSPA2	3017	-271
HSPA4	2060	963
HSPA4L	-884	-5898
HSPA9	-3436	-200
HSPH1	-3256	993
ID1	1843	-3980
ITFG2	-3938	-873
JUN	1286	69
KAT5	405	-650
KDM6B	3909	-92
KEAP1	1826	-2872
KPTN	2550	1279
LAMTOR1	4371	-5950
LAMTOR2	3287	1882
LAMTOR3	3292	321
LAMTOR4	1619	-6150
LAMTOR5	3865	-5095
LIMD1	-3980	-6080
LMNB1	4342	-942
LRPPRC	-3590	-5728
MAFK	288	-2942
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAP3K5	3365	-4989
MAP4K4	3823	2014
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPK8	-3265	6
MAPK9	-2259	872
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MDM2	1551	-1318
MDM4	-385	-2440
MED1	-1206	-2271
MEF2D	-929	-3018
MINK1	1269	-4004
MIOS	1132	561
MLST8	117	287
MOV10	-4681	-6449
MRPL18	675	-1383
MT1F	3330	-4560
MT1X	2114	-2005
MT2A	-2224	1556
MTF1	4102	-2992
MTOR	-3429	-1813
NBN	717	750
NCF4	4298	-6732
NCOA2	343	1407
NCOA6	2280	-1860
NCOR1	2341	-3738
NCOR2	3557	-4281
NDC1	-4789	-5228
NDUFA4	2661	288
NFE2L2	2808	-1441
NLRP3	4089	-6357
NPRL2	-4453	2371
NPRL3	1645	2138
NR1D1	-3070	1187
NR3C1	162	-2420
NR3C2	-3885	324
NUDT2	963	-2046
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
P4HB	3831	-1549
PHC1	-2820	-5180
PHC2	4171	1830
PHC3	-2698	1805
POM121	-2766	-1787
POM121C	-2305	-4315
PPP1R15A	2389	-5399
PRDX1	2981	-877
PRDX2	1157	-5158
PRDX3	4351	972
PRDX5	3882	-1661
PRDX6	4109	916
PRKCD	4154	584
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTGES3	1450	-1810
RAD50	-2373	2067
RAE1	1963	-39
RAI1	-1577	-2874
RANBP2	-273	-4704
RB1	3985	-4740
RBBP4	-565	-3282
RBX1	1368	-3241
RELA	-542	2085
RHEB	3356	-2334
RING1	-1216	-1490
RNF2	1192	-1936
RORA	-4672	2287
RPA1	-4688	-2495
RPA3	-3040	-1890
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS19BP1	863	436
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
RPTOR	-3804	2134
RRAGA	2539	-1657
RRAGC	1856	-2585
RRAGD	4008	-6311
SCMH1	-1799	1397
SCO1	-3455	-1715
SCO2	-1303	-4657
SEC13	2266	-3749
SEH1L	-1875	-1615
SERPINH1	-3616	-1891
SESN1	-3059	-3887
SESN2	1099	-3423
SIN3A	-3818	-4151
SIN3B	-1256	570
SIRT1	-1254	-1775
SKP1	1536	-2290
SKP2	-2759	-1566
SLC38A9	906	-3360
SOD1	-1475	-1019
SOD2	1587	573
SP1	3686	-3141
ST13	-390	-5101
STAT3	3628	-3606
STIP1	-632	31
SURF1	1204	-4976
SZT2	-1622	-5754
TACO1	1600	-5534
TBL1XR1	1669	962
TCIRG1	3087	-5082
TERF1	-1070	-1932
TERF2	-1332	982
TERF2IP	1903	-4579
TFDP1	3849	-1587
TFDP2	-4891	-4793
TINF2	1687	-1513
TNIK	-4494	-2132
TNRC6A	-1710	-5420
TNRC6B	-1353	2270
TP53	-4034	-739
TPR	-2242	-973
TRIB3	-1802	1669
TXN	3732	284
TXN2	1714	-257
TXNIP	-3347	-2777
TXNRD1	3685	-4647
TXNRD2	3261	-5499
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2C	1933	1091
UBE2D1	4255	-1581
UBE2D2	1717	-3799
UBE2D3	3944	-373
UBE2E1	2822	-5882
UBE2S	1766	2449
UBN1	2066	-3899
VCP	2902	-2411
VEGFA	3235	-2723
VHL	1262	1389
WDR24	361	-6152
WDR59	-3189	-1721
XPO1	-371	-870
YWHAE	4173	-4168

---

---

EPH-Ephrin signaling

EPH-Ephrin signaling

metric	value
setSize	55
pMANOVA	3.52e-08
p.adjustMANOVA	1.57e-06
s.dist	0.465
s.RNA	0.451
s.meth	-0.112
p.RNA	7.45e-09
p.meth	0.153

Top 20 genes

Gene	RNA	meth
LIMK2	3615	-6093
CLTCL1	4130	-4995
CLTA	3788	-5077
ACTB	4156	-4515
NCSTN	4254	-3821
ARPC5	3968	-3837
PAK1	3703	-3995
PAK2	3682	-3961
ARPC3	3729	-3767
AP2A1	2869	-4887
PSEN1	3540	-3407
ACTR2	3481	-3374
AP2S1	3581	-3262
ARPC2	3191	-3647
VAV3	1824	-6342
SDCBP	4324	-2535
ACTR3	3448	-2917
CDC42	3268	-2719
CLTB	2446	-3627
APH1A	1453	-6066

Click HERE to show all gene set members

All member genes

	RNA	meth
ACTB	4156	-4515
ACTG1	3901	1793
ACTR2	3481	-3374
ACTR3	3448	-2917
ADAM10	4030	976
AP2A1	2869	-4887
AP2M1	3936	20
AP2S1	3581	-3262
APH1A	1453	-6066
APH1B	2555	2056
ARHGEF7	-1379	-5507
ARPC1B	4291	-2022
ARPC2	3191	-3647
ARPC3	3729	-3767
ARPC5	3968	-3837
CDC42	3268	-2719
CFL1	3683	912
CLTA	3788	-5077
CLTB	2446	-3627
CLTC	4149	2477
CLTCL1	4130	-4995
DNM1	1225	-5619
EFNA3	-2639	568
EFNA4	2473	-3312
EFNB2	-1915	-5564
EPHA4	-4347	630
EPHB6	50	-5408
FYN	-4495	1957
GIT1	-3293	-6740
HRAS	-1008	-4780
ITSN1	4309	-1048
LIMK1	1730	-3787
LIMK2	3615	-6093
MYH10	206	-4405
MYH9	2789	2182
MYL12A	2908	-2655
MYL6	3908	-19
NCK2	1848	-4310
NCSTN	4254	-3821
PAK1	3703	-3995
PAK2	3682	-3961
PSEN1	3540	-3407
PSEN2	-2508	-5155
PSENEN	2260	-3620
PTK2	1629	920
RAC1	4031	971
RASA1	664	-167
RHOA	3753	1313
ROCK1	3246	-985
SDCBP	4324	-2535
SRC	-2999	-4427
VAV2	-1214	-643
VAV3	1824	-6342
WASL	87	-4742
YES1	-4772	-4415

---

---

Asparagine N-linked glycosylation

Asparagine N-linked glycosylation

metric	value
setSize	222
pMANOVA	3.9e-08
p.adjustMANOVA	1.68e-06
s.dist	0.227
s.RNA	0.226
s.meth	0.0172
p.RNA	8.02e-09
p.meth	0.661

Top 20 genes

Gene	RNA	meth
KDELR1	4226	1780
TMED7	3534	1939
PPP6C	2859	2020
DAD1	2346	2452
GLB1	3992	1368
GOLGA2	2513	1847
COPA	3780	1056
MGAT1	2546	1169
DCTN6	3145	819
ALG14	2265	1103
PDIA3	1451	1466
CAPZA1	3648	572
NANS	3538	529
USO1	1467	1196
SAR1B	2676	489
CTSC	739	1561
MLEC	737	953
COPE	2906	213
SRD5A3	1390	442
ST6GALNAC3	4221	145

Click HERE to show all gene set members

All member genes

	RNA	meth
ACTR10	3309	-1291
ACTR1A	2965	-1
ALG10	-2662	-346
ALG10B	-2740	966
ALG11	-1067	-549
ALG12	849	-1300
ALG14	2265	1103
ALG2	-391	-625
ALG3	-392	-2680
ALG5	-228	-2175
ALG6	513	-4449
ALG8	-1083	-3591
ALG9	-3428	-1148
AMDHD2	-3859	539
AMFR	3176	-6742
ANK1	4018	-4221
ANK3	-1491	-6563
ANKRD28	-1940	-5108
ARCN1	2180	-1676
ARF1	4184	-6686
ARF3	3396	-1912
ARF4	4256	-3280
ARF5	3493	-4789
ARFGAP1	-582	1688
ARFGAP3	1282	-5386
B4GALT1	1540	-160
B4GALT2	-1862	1307
B4GALT3	-3962	-4680
B4GALT4	121	-1422
B4GALT5	4052	52
B4GALT6	-2986	-6484
BET1	-192	-4482
BET1L	-2389	332
CALR	2586	-3753
CANX	2151	-4839
CAPZA1	3648	572
CAPZA2	3920	-36
CAPZB	3576	-4065
CD55	4229	-3923
CD59	2326	-6024
CHST10	-4598	-5927
CMAS	4057	-2712
CNIH1	3425	-6699
COG1	-4760	-3663
COG2	-2597	-6132
COG3	-1652	-5701
COG4	-3	-984
COG5	-970	-1864
COG6	-1787	-358
COG7	1526	-4196
COG8	-118	1846
COPA	3780	1056
COPB1	3154	-1329
COPB2	3503	-1501
COPE	2906	213
COPZ1	1422	-5051
COPZ2	-4019	1305
CSNK1D	760	-1777
CTSA	4412	-4847
CTSC	739	1561
CTSZ	4137	-6765
DAD1	2346	2452
DCTN2	4235	-6011
DCTN3	2396	-4272
DCTN4	3796	-2073
DCTN5	-1222	-5100
DCTN6	3145	819
DERL1	-3060	123
DERL2	987	-2287
DHDDS	-673	-4895
DOLK	-1085	-2245
DOLPP1	919	-914
DPAGT1	678	650
DPM1	482	-2366
DPM2	1751	-1939
DPM3	823	-2637
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNLL1	2378	-3319
DYNLL2	-1189	214
EDEM1	-36	1523
EDEM2	3982	-3093
ENGASE	-2450	-5741
FPGT	3127	-2826
FUCA1	3203	-5579
FUOM	-1578	-5803
FUT8	-3421	-2455
GANAB	-317	-3501
GBF1	-1279	-120
GFPT1	-2014	-2828
GLB1	3992	1368
GMDS	1849	-1375
GMPPA	1347	-4201
GMPPB	-2358	1238
GNE	-1580	-4921
GNPNAT1	-3379	-2849
GOLGA2	2513	1847
GOLGB1	-1635	-3196
GORASP1	2742	-2178
GOSR1	-61	-3152
GOSR2	-454	1643
KDELR1	4226	1780
KDELR2	3393	-2980
LMAN1	-3888	596
LMAN2	3016	-2497
LMAN2L	2928	-1590
MAN1A1	3520	-447
MAN1A2	-619	-1465
MAN1B1	-1477	2249
MAN1C1	-2148	-1205
MAN2A1	-418	-4486
MAN2A2	2751	-5172
MANEA	-226	172
MCFD2	3031	-158
MGAT1	2546	1169
MGAT2	507	-1666
MGAT4A	-1741	-2254
MGAT4B	3961	-6439
MGAT5	-918	-5572
MIA3	-1938	-3428
MLEC	737	953
MOGS	-913	-2356
MPDU1	3413	-1260
MPI	-3963	-5890
MVD	-1805	1954
NAGK	1038	-5552
NANP	-3279	-585
NANS	3538	529
NAPA	438	-4125
NAPB	-838	471
NAPG	1458	-97
NEU1	4167	-3878
NEU3	-1138	-1409
NGLY1	-1096	-236
NPL	4408	-6573
NUS1	3476	-9
OS9	4087	-975
PDIA3	1451	1466
PGM3	-297	1964
PMM1	1483	-1060
PMM2	428	-2687
PPP6C	2859	2020
PPP6R1	2015	-1276
PPP6R3	1081	-3726
PRKCSH	1991	-3007
PSMC1	2977	-5705
RAB1A	4176	-1703
RAB1B	3749	-264
RAD23B	4081	-3906
RFT1	1549	147
RNF103	-1360	-2036
RNF139	842	354
RNF185	2681	-2775
RNF5	-1999	-4625
RPN1	3580	-2841
RPN2	3058	-688
RPS27A	-2201	-2138
SAR1B	2676	489
SEC13	2266	-3749
SEC16A	1697	-1722
SEC22A	-1537	696
SEC22C	-1264	1879
SEC23A	3162	-5141
SEC23IP	-154	-38
SEC24A	3350	61
SEC24B	1233	-5505
SEC24C	-768	805
SEC24D	3637	-3966
SEC31A	346	-4985
SEL1L	2877	-2307
SLC17A5	1875	-3631
SLC35A1	3104	-4021
SLC35C1	880	-5366
SPTAN1	-4344	-1250
SPTBN1	-2529	-3924
SPTBN5	-1052	2344
SRD5A3	1390	442
ST3GAL1	-2406	1767
ST3GAL2	3958	-2686
ST3GAL3	158	-1055
ST3GAL4	2285	-4996
ST3GAL5	-4428	1507
ST3GAL6	2794	-5427
ST6GAL1	-4715	1948
ST6GALNAC3	4221	145
ST6GALNAC4	-207	-5981
ST6GALNAC6	-4734	2144
ST8SIA1	-2612	-2246
ST8SIA4	3708	-3013
STT3A	1442	-4222
STX17	-4100	-4247
STX5	3071	-1823
SYVN1	313	-5153
TBC1D20	-8	-5205
TGFA	4083	-3020
TMED10	94	604
TMED2	2424	-3656
TMED3	868	-2936
TMED7	3534	1939
TMED9	3072	-1992
TMEM115	2141	-703
TRAPPC1	3441	-3029
TRAPPC10	-3243	2388
TRAPPC2L	-686	1441
TRAPPC3	3041	-2853
TRAPPC4	-2106	-3231
TRAPPC5	1974	-5629
TRAPPC6A	-4050	1765
TRAPPC6B	1463	-662
TRAPPC9	2048	-4354
TRIM13	-675	497
UAP1	-4784	-3110
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBXN1	595	-2222
UGGT1	1923	-3498
USO1	1467	1196
VCP	2902	-2411
YKT6	1980	-3331

---

---

RNA Polymerase II Transcription

RNA Polymerase II Transcription

metric	value
setSize	895
pMANOVA	4.61e-08
p.adjustMANOVA	1.91e-06
s.dist	0.115
s.RNA	-0.11
s.meth	-0.0335
p.RNA	6.09e-08
p.meth	0.0991

Top 20 genes

Gene	RNA	meth
MOV10	-4681	-6449
ZNF530	-4722	-6175
ZKSCAN8	-4228	-6728
ZNF568	-4485	-6314
ZNF528	-4227	-6459
ZNF354C	-4210	-6378
AUTS2	-4738	-5652
ZNF211	-4299	-6023
ZNF549	-4632	-5587
CCND2	-4535	-5700
PARP1	-4548	-5521
ERBB2	-4865	-5145
ZNF620	-4534	-5485
ZNF550	-4164	-5905
ZNF43	-4578	-5370
ZNF70	-4592	-5340
ZNF287	-4785	-5090
ZNF571	-4564	-5324
CNOT6L	-4229	-5686
PIP4K2C	-4309	-5573

Click HERE to show all gene set members

All member genes

	RNA	meth
ABL1	63	-4891
ACTL6A	-2416	-4851
AFF4	419	-5010
AGO1	2217	1997
AGO2	967	2447
AGO3	-324	-6442
AKT1	1234	-1942
AKT2	133	-141
ALYREF	2102	-4902
ANAPC1	-4659	403
ANAPC10	-1520	-6111
ANAPC11	2490	344
ANAPC15	4132	-1379
ANAPC16	-640	-4507
ANAPC2	-2390	-1007
ANAPC4	-2075	-1696
ANAPC5	-4080	-2530
ANAPC7	-1573	1560
APAF1	4158	-2104
ARID1A	1797	-6716
ARID1B	-1675	1093
ARID2	-1173	-657
ARID3A	3913	-4723
ASH2L	2400	-3791
ATAD2	-3906	-1835
ATM	-4170	202
ATR	-3743	970
ATRIP	-4384	-2737
ATXN3	495	1703
AURKA	1109	-385
AURKB	269	-889
AUTS2	-4738	-5652
AXIN1	-3703	-5655
BANP	214	-4163
BARD1	-1019	-2910
BAX	2357	-3623
BBC3	-2571	-3845
BCL2L11	3187	1781
BCL6	4248	-299
BID	2410	844
BIRC5	1291	-84
BLM	-1418	-2909
BMI1	-3460	-6383
BNIP3L	4333	-851
BRCA1	2542	-4609
BRD1	-4094	2465
BRD2	-3390	1256
BRD7	-5	-5008
BRIP1	-4454	-2323
BRPF1	-2319	89
BRPF3	-2062	-937
BTG1	-1583	2084
BTG2	1017	-1900
CALM1	-626	-5019
CAMK2D	-4581	-2867
CAMK2G	601	2354
CAMK4	-3531	1482
CASC3	2005	-2580
CASP1	1501	-1448
CASP10	-1032	-6612
CASP6	-856	-4898
CAT	4214	-3922
CAV1	619	-2432
CBFB	656	-3766
CBX3	1794	-859
CBX4	699	-5288
CBX6	1421	-3511
CBX8	2112	2207
CCNA2	520	-1132
CCNB1	147	1492
CCNC	589	-1138
CCND1	-2214	-6213
CCND2	-4535	-5700
CCND3	3245	905
CCNE1	-4514	-3403
CCNE2	1953	-3396
CCNG1	1818	131
CCNG2	2753	-3720
CCNH	243	-3754
CCNK	923	-6142
CCNT1	-3292	1773
CDC16	-1877	-4152
CDC23	-4259	-707
CDC25C	1865	-2877
CDC40	2845	2242
CDC7	-2568	-202
CDC73	1891	-2092
CDK1	472	-4215
CDK12	-421	-805
CDK13	-2814	-700
CDK2	-1522	1018
CDK4	-4235	-1295
CDK5	3929	-506
CDK5R1	-346	-2113
CDK6	-2015	-2864
CDK7	1983	275
CDK8	-594	-5509
CDK9	-1171	1524
CDKN1A	1646	-3540
CDKN1B	-2723	-862
CDKN2A	-1595	-4511
CEBPB	3564	-5089
CENPJ	-4330	-838
CHD3	-3413	422
CHD4	-1351	-4634
CHEK1	-741	-211
CHEK2	-1302	-2709
CITED2	2659	-104
CITED4	3463	-701
CLP1	2730	-1417
CNOT1	-1273	-4543
CNOT10	-811	-361
CNOT11	663	-2236
CNOT3	2042	565
CNOT4	-399	-3064
CNOT6	1783	-3728
CNOT6L	-4229	-5686
CNOT7	-1154	349
CNOT8	3701	-2054
COX11	-4412	-789
COX14	-471	-3835
COX16	34	-1160
COX19	-2178	-4047
COX20	-1527	-4841
COX4I1	1484	-5506
COX5A	2495	-2944
COX5B	2517	382
COX6A1	1930	-961
COX6B1	2224	-2634
COX6C	220	-1411
COX7A2L	3386	-2476
COX7C	176	-4071
COX8A	2745	-1258
CPSF1	-1130	-6284
CPSF2	3459	-3164
CPSF3	2740	-4860
CPSF4	-3261	134
CRADD	1987	-4017
CREB1	-430	-672
CREBBP	1153	-5804
CSNK2A2	2614	-4422
CSNK2B	1389	-998
CSTF1	-1891	2021
CTDP1	2503	1112
CTLA4	-3751	2506
CTNNB1	2626	-1691
CTR9	1117	-5535
CTSL	1504	-6671
CTSV	-910	-5834
CUL1	-4281	-5146
CYCS	-411	-3927
DAXX	-3855	-450
DDB2	-4408	-561
DDIT3	1831	-3177
DDIT4	-717	-2588
DEK	853	1060
DGCR8	-4568	-495
DNA2	-865	-2087
DPY30	1300	-1010
DYRK2	-4569	-3036
E2F1	2589	-1005
E2F4	2567	-172
E2F5	-2887	-2646
E2F6	-1514	-2466
E2F7	-1774	-1622
E2F8	918	-4363
EAF1	2153	-4156
EED	-3235	-1174
EHMT1	-2937	-1697
EHMT2	-2883	-1059
EIF4A3	3132	-3850
ELF1	505	-1733
ELF2	834	-3373
ELL	1886	574
ELL2	3452	-3578
ELL3	192	-2569
EP300	2471	-4509
EPC1	-3513	-2797
ERBB2	-4865	-5145
ERCC2	1210	-594
ERCC3	-2534	969
ESR2	-3194	-2661
ESRRA	2372	-2927
EXO1	-488	-3123
EZH2	-3415	-20
FANCC	-4417	-3902
FANCD2	-4343	1778
FANCI	-4640	-4622
FAS	1281	-5824
FBXO32	-3875	-1875
FBXW7	-2055	-5428
FIP1L1	-2603	-2274
FKBP5	4199	-5653
FOS	2120	2149
FOXO1	-3290	-5036
FOXO3	3966	711
FYTTD1	-1781	1459
FZR1	-670	-758
GADD45A	4195	-2249
GATA3	-4799	1861
GATAD2A	999	-256
GATAD2B	-535	-2871
GLS	-4610	-4781
GPAM	-3683	-4630
GPI	2558	-2211
GPS2	-293	-857
GSK3B	2756	736
GSR	4276	-4724
GTF2A1	865	271
GTF2A2	3006	-1036
GTF2B	1193	-3218
GTF2E2	2276	-184
GTF2F1	1854	-1723
GTF2F2	2104	-2885
GTF2H3	-672	1025
GTF2H4	-876	-2761
GTF2H5	1345	691
HDAC1	184	-1016
HDAC10	721	-1304
HDAC11	1771	-3595
HDAC2	2129	-46
HDAC3	1727	-3771
HDAC4	4126	-3817
HDAC5	1746	-3144
HDAC7	2465	-4900
HEY2	-3420	2330
HIPK1	2325	-974
HIPK2	2441	-1520
HIVEP3	-843	2288
HSPD1	-562	-2021
HUS1	-45	-522
ICE2	-3053	1344
IL2RA	-2295	-6462
ING2	1603	-2115
ING5	-3565	-763
INTS1	241	-1451
INTS10	1539	-1477
INTS12	47	1798
INTS2	-581	-5323
INTS3	2533	1491
INTS4	-3220	-2255
INTS5	-321	-2452
INTS6	2228	-1482
INTS7	-2590	-3259
INTS8	3618	-1509
INTS9	-2036	-2341
ITCH	407	-1366
ITGA4	-4122	1419
ITGA5	3349	-6767
ITGAL	-4012	2268
IWS1	2345	-60
JMY	-4372	-4364
JUN	1286	69
JUNB	2850	-3031
KAT2A	-3970	-5050
KAT2B	-722	-1588
KAT5	405	-650
KCTD1	-569	-6296
KCTD6	1579	886
KMT2A	-3942	2484
KMT2C	17	-6379
KMT2D	1057	-6199
KMT2E	-1879	2390
KRAS	1276	440
L3MBTL2	-3969	-4114
LAMTOR1	4371	-5950
LAMTOR2	3287	1882
LAMTOR3	3292	321
LAMTOR4	1619	-6150
LAMTOR5	3865	-5095
LBR	3631	-3506
LDB1	-3712	1270
LEO1	10	791
LMO2	3746	-5492
LRPPRC	-3590	-5728
LSM10	2585	-3871
LSM11	-3779	-4172
MAF	-3821	-4350
MAML1	2088	-5348
MAML2	-189	-2078
MAML3	4123	-4054
MAP2K6	4082	-1130
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPKAP1	1911	1057
MAX	1511	-3235
MBD3	-170	1673
MDC1	-4716	-902
MDM2	1551	-1318
MDM4	-385	-2440
MEAF6	-2677	-3609
MED1	-1206	-2271
MED10	-2893	-2572
MED13	807	590
MED15	-3434	2114
MED16	2024	1719
MED17	1004	-1418
MED20	2814	-542
MED23	-2139	633
MED24	-2380	-2701
MED25	2518	-1286
MED26	1589	18
MED27	-3167	-960
MED30	-1669	491
MED31	447	445
MED4	1062	-4472
MED6	-279	560
MED7	62	778
MED8	3267	1289
MEN1	-2877	-2311
MGA	-3528	-3489
MLLT1	3450	-1901
MLLT3	-3560	1273
MLST8	117	287
MNAT1	-2935	311
MOV10	-4681	-6449
MSH2	-4382	83
MTA2	-2350	1649
MTOR	-3429	-1813
MYB	88	1502
NABP1	3567	-209
NABP2	-2330	-6524
NBN	717	750
NCBP1	-1807	-3745
NCBP2	-3329	-4067
NCOR1	2341	-3738
NCOR2	3557	-4281
NDRG1	1712	149
NDUFA4	2661	288
NEDD4L	3485	-5066
NELFA	-1157	35
NELFB	115	1822
NELFCD	-1954	2444
NELFE	1342	1377
NFATC2	-4851	2414
NFE2	4380	-6723
NFYA	1189	1464
NFYB	-3536	-531
NFYC	3345	-3078
NOP2	-3530	-2438
NOTCH1	1743	1722
NOTCH4	-1593	-6455
NR1D1	-3070	1187
NR1D2	-3728	663
NR1H2	3207	-1471
NR1H3	-1069	-2305
NR1I2	-1321	-4903
NR2C1	-3506	-1463
NR2C2	-2910	119
NR2C2AP	-4442	-4688
NR3C1	162	-2420
NR3C2	-3885	324
NR4A1	-2128	657
NR4A2	-490	1416
NR4A3	-1547	954
NR6A1	3895	-5344
NRBP1	895	-1365
NUDT21	-1100	13
PABPN1	-169	-3743
PAF1	1180	-5838
PAPOLA	3065	775
PARP1	-4548	-5521
PBRM1	2173	2290
PCBP4	-4128	-1359
PCGF5	-989	-3951
PCGF6	-222	-3963
PCNA	-1833	-511
PDPK1	2474	167
PHAX	-1605	694
PHC1	-2820	-5180
PHC2	4171	1830
PHC3	-2698	1805
PHF20	-579	904
PIDD1	-2076	-6641
PIN1	-955	-1656
PINK1	4113	-3597
PIP4K2A	-707	1772
PIP4K2B	-2535	-6347
PIP4K2C	-4309	-5573
PLAGL1	139	1666
PLK2	-827	-6257
PLK3	2787	1597
PMAIP1	-4091	-2202
PML	-2938	549
PMS2	-1678	1574
POLDIP3	3131	-5416
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
POU2F1	470	733
POU2F2	1518	950
PPARD	-1990	660
PPARGC1B	-1534	1840
PPM1A	3687	-3764
PPM1D	3444	-4316
PPP1R13B	-4473	1874
PPP1R13L	125	328
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5C	-4242	2376
PRDM1	-3015	799
PRDX1	2981	-877
PRDX2	1157	-5158
PRDX5	3882	-1661
PRKAA1	409	227
PRKAB1	401	-3297
PRKAB2	-2709	-1428
PRKACA	4378	-6032
PRKAG1	2126	-5980
PRKAG2	636	-5033
PRKCB	3029	-4518
PRKCQ	-4762	1372
PRMT1	-3186	-740
PRMT5	1232	-2112
PRR5	-4676	-1591
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTEN	3844	-1100
PTPN1	2254	2074
PTPN11	2038	-2302
PTPN4	-4818	-3156
RABGGTA	-734	1696
RABGGTB	-1597	2306
RAD1	-4807	1965
RAD17	-3716	-1101
RAD50	-2373	2067
RAD51	-835	-696
RAD51D	-4336	-710
RAD9A	-4349	-403
RAD9B	1008	-6145
RARA	2642	-5249
RARG	-1567	-5402
RB1	3985	-4740
RBBP4	-565	-3282
RBBP5	328	-779
RBBP8	-1554	-5854
RBL1	-3533	-3466
RBL2	-2519	-4497
RBM14	-2431	398
RBPJ	4017	-1118
RBX1	1368	-3241
RELA	-542	2085
RFC2	1853	-1206
RFC3	-3815	-803
RFC4	-3929	624
RFC5	-4518	-4946
RFFL	-515	-5968
RGCC	-2550	2408
RHEB	3356	-2334
RHNO1	-2003	-2816
RICTOR	-3383	1651
RING1	-1216	-1490
RMI2	-1212	1934
RNF111	2267	779
RNF2	1192	-1936
RNF34	-1902	42
RNGTT	1007	-2952
RNMT	-4139	2172
RNPS1	-4345	-3160
RORA	-4672	2287
RPA1	-4688	-2495
RPA3	-3040	-1890
RPAP2	-3047	-3782
RPRD1A	1677	-3000
RPRD2	-1349	-2123
RPS27A	-2201	-2138
RPTOR	-3804	2134
RRAGA	2539	-1657
RRAGC	1856	-2585
RRAGD	4008	-6311
RRM2	-62	-574
RRM2B	2842	-5757
RTF1	1201	-4613
RUNX1	3262	-4082
RUNX2	-4180	-5055
RUNX3	-4885	2402
RYBP	2154	1520
SATB2	2834	-6456
SCMH1	-1799	1397
SCO1	-3455	-1715
SCO2	-1303	-4657
SESN1	-3059	-3887
SESN2	1099	-3423
SESN3	-1054	1141
SETD1A	-1763	-2070
SETD1B	231	-5034
SETD9	-389	-6605
SFN	500	-5994
SGK1	1689	-6076
SIN3A	-3818	-4151
SIN3B	-1256	570
SIRT1	-1254	-1775
SIRT3	-3016	-1430
SKI	-4153	-2431
SKIL	-234	-3633
SKP1	1536	-2290
SKP2	-2759	-1566
SLBP	2050	-327
SLC2A3	4160	-4757
SLC38A9	906	-3360
SLU7	871	-3467
SMAD1	3872	-3272
SMAD2	1830	-1994
SMAD3	-4538	-4628
SMAD4	-2796	-6535
SMAD6	3456	-3209
SMAD7	-4617	-4450
SMARCA2	-821	296
SMARCA4	1758	2317
SMARCB1	-1149	-714
SMARCC1	-3025	1327
SMARCC2	-1236	-3828
SMARCD1	-4499	-2643
SMARCD2	2918	967
SMARCE1	-1290	-3418
SMURF1	-780	1321
SMURF2	-3735	-3048
SMYD2	-3787	-3757
SNAPC1	173	343
SNAPC2	1901	-3914
SNAPC3	-2801	-4100
SNAPC4	-271	-6719
SNAPC5	-1124	1443
SNRPB	-718	-2182
SNRPD3	518	1486
SNRPE	194	-919
SNRPG	512	-4002
SNW1	1979	946
SOCS3	4399	2178
SOCS4	-1512	-1919
SOD2	1587	573
SP1	3686	-3141
SPI1	4085	-6766
SRC	-2999	-4427
SREBF1	2701	-4015
SRRM1	-1535	-2963
SRRT	-1601	-3758
SRSF11	-3554	-5151
SRSF2	-1991	2284
SRSF3	-682	-121
SRSF4	1324	-2328
SRSF7	-3031	2075
SRSF9	3210	-3686
SSRP1	-4179	-2441
SSU72	1218	-4327
STAT1	-4529	2195
STK11	723	-5709
STUB1	-330	-2168
SUMO1	2903	-3986
SUPT16H	-4301	-3702
SUPT4H1	930	-1899
SUPT5H	-2108	-3641
SUPT6H	-1995	285
SURF1	1204	-4976
SYMPK	-1895	-2815
TACO1	1600	-5534
TAF10	3039	1606
TAF11	-881	-719
TAF12	3552	-1765
TAF13	3098	-908
TAF15	-2008	-3109
TAF2	-1828	-4149
TAF3	-559	-3002
TAF4	-516	-6161
TAF4B	-2666	-1647
TAF5	-1350	1150
TAF6	-2367	1804
TAF7	673	-3426
TAF8	1236	342
TAF9	388	1714
TBL1XR1	1669	962
TCEA1	-309	-4211
TCF12	-386	-4702
TCF3	-2318	-6049
TCF7	-3643	2023
TCF7L2	-1917	-3431
TFAP2E	-1949	-6087
TFDP1	3849	-1587
TFDP2	-4891	-4793
TGFA	4083	-3020
TGFB1	1959	-6
TGIF1	-2933	-5815
TGIF2	-3603	-6609
THOC1	-3681	73
THOC5	3107	747
THOC7	2564	-369
THRA	-1986	-2798
TIGAR	2514	-1893
TMEM219	1336	-6062
TNFRSF10A	561	-3935
TNFRSF10B	3754	1433
TNFRSF10D	4189	-5911
TNKS1BP1	-1672	-5457
TNRC6A	-1710	-5420
TNRC6B	-1353	2270
TOP3A	3549	-3594
TOPBP1	-1033	180
TP53	-4034	-739
TP53BP2	2152	-5830
TP53I3	4139	-6077
TP53INP1	2660	-2058
TP53RK	-4708	-2342
TPX2	479	-4637
TRIAP1	82	-3808
TRIM28	-1538	1191
TRIM33	-3001	-2091
TSC1	-638	1527
TSC2	-262	895
TTC5	-795	-1440
TXN	3732	284
TXNIP	-3347	-2777
TXNRD1	3685	-4647
U2AF1	398	-5640
U2AF1L4	-1283	2171
U2AF2	1256	-306
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2C	1933	1091
UBE2D1	4255	-1581
UBE2D3	3944	-373
UBE2E1	2822	-5882
UBE2I	-245	233
UBE2S	1766	2449
USP7	2576	-2216
VDR	3768	-3651
VEGFA	3235	-2723
WDR33	-2506	-3224
WDR5	39	-5613
WDR61	22	-4752
WRN	-4713	-2102
WWOX	-4138	1732
WWP1	-3604	-1865
YAF2	-2375	-3920
YEATS4	-1167	1953
YES1	-4772	-4415
YWHAB	2611	2125
YWHAE	4173	-4168
YWHAG	4294	-5545
YWHAH	3949	-2902
YWHAQ	-2362	-2908
YWHAZ	2200	541
YY1	169	-5165
ZC3H8	-3594	-3807
ZFHX3	3213	-2025
ZFP1	-3852	-2240
ZFP14	-3635	1678
ZFP28	-2155	-6320
ZFP30	-4185	-366
ZFP37	-2868	-5928
ZFP90	-3354	824
ZFPM1	-3657	2378
ZIK1	-4120	2035
ZKSCAN1	679	-3843
ZKSCAN3	-2686	-5530
ZKSCAN4	-1570	-5770
ZKSCAN5	413	468
ZKSCAN8	-4228	-6728
ZNF10	-4018	-1897
ZNF101	-1711	2155
ZNF136	-4348	-3471
ZNF138	-4303	-5255
ZNF14	-4209	-4397
ZNF140	-2969	-2581
ZNF141	-3147	-526
ZNF143	3128	-418
ZNF155	-1525	-4127
ZNF160	-3076	-2923
ZNF169	-1933	-737
ZNF17	-3236	-1485
ZNF175	-2613	-5289
ZNF18	-763	-3535
ZNF180	-3911	-2110
ZNF184	-4134	-1046
ZNF189	1184	2001
ZNF19	-4117	907
ZNF2	-2490	-5367
ZNF20	1739	-4807
ZNF200	-49	-1750
ZNF202	-4295	1338
ZNF211	-4299	-6023
ZNF212	-3620	620
ZNF213	2377	-1128
ZNF215	-1104	-2720
ZNF221	-932	-6268
ZNF222	-27	-1983
ZNF223	-2186	-6465
ZNF224	-3540	-2768
ZNF226	-4079	-3429
ZNF227	-3454	-1334
ZNF23	-3922	-3592
ZNF233	-1172	-4234
ZNF234	-2858	-5598
ZNF235	-4402	-5194
ZNF248	-4224	-3321
ZNF25	-1662	-5487
ZNF250	-4622	554
ZNF253	-3902	-1053
ZNF257	-3934	-3813
ZNF26	-3503	-3960
ZNF264	-2391	-4068
ZNF268	-2180	-5808
ZNF274	-2926	-5798
ZNF282	1823	-5468
ZNF286A	-4566	-2915
ZNF287	-4785	-5090
ZNF3	-4783	-1141
ZNF302	-4002	659
ZNF311	-3401	-5855
ZNF324	-3485	-3484
ZNF324B	-4083	651
ZNF331	-2940	-2081
ZNF333	1406	-2425
ZNF337	-4450	-3809
ZNF33A	-2069	157
ZNF33B	-4633	-2030
ZNF34	-1702	-964
ZNF343	-4192	-4524
ZNF354A	1349	-4473
ZNF354C	-4210	-6378
ZNF382	-2513	-4717
ZNF394	408	-628
ZNF398	-1801	155
ZNF417	-1650	-2829
ZNF418	-2453	-6578
ZNF419	-4356	-5268
ZNF420	-3816	-3752
ZNF425	-2185	-4710
ZNF426	-1310	-3104
ZNF43	-4578	-5370
ZNF430	-1468	-4879
ZNF431	-3368	-5647
ZNF432	-4068	-5374
ZNF436	-3527	-5576
ZNF440	-2954	-5938
ZNF443	-1565	-4894
ZNF445	1111	-5606
ZNF446	-3697	-3030
ZNF461	-4655	-2540
ZNF468	-519	-4348
ZNF470	-3363	-6469
ZNF480	-2012	-4983
ZNF483	-3488	-5903
ZNF484	-3318	-304
ZNF490	-788	-2501
ZNF492	-1392	-6580
ZNF496	-4377	-3057
ZNF500	-4575	1026
ZNF506	-3274	-4344
ZNF517	-4437	-228
ZNF528	-4227	-6459
ZNF529	-3806	-3659
ZNF530	-4722	-6175
ZNF540	-4146	-4576
ZNF546	-1454	-1610
ZNF547	-1616	-4822
ZNF549	-4632	-5587
ZNF550	-4164	-5905
ZNF552	1735	-5023
ZNF554	-4479	-1275
ZNF559	-2851	-4261
ZNF561	-1281	-2945
ZNF563	-3853	-5992
ZNF564	-1354	-2468
ZNF566	-4380	-939
ZNF567	-3075	-5136
ZNF568	-4485	-6314
ZNF569	-4403	-352
ZNF570	-4429	-4872
ZNF571	-4564	-5324
ZNF573	-3474	-3023
ZNF582	-3463	-6112
ZNF583	-3403	-4848
ZNF584	-4162	-5742
ZNF585A	-2547	-4862
ZNF585B	-3869	-2710
ZNF587	-52	-1759
ZNF589	-1680	1425
ZNF596	-3483	-6669
ZNF597	-3369	-4633
ZNF600	-4273	-5453
ZNF605	-773	-1335
ZNF606	-3225	-5401
ZNF610	-1916	-6042
ZNF611	-1413	-5441
ZNF613	615	-5448
ZNF614	-3337	-2566
ZNF615	-1623	-5583
ZNF619	-2957	-6317
ZNF620	-4534	-5485
ZNF621	-4107	-3523
ZNF624	-982	-3879
ZNF627	-328	-2790
ZNF641	-2580	-5851
ZNF655	-1035	-2976
ZNF664	-3459	1571
ZNF665	-2634	-6565
ZNF668	1289	1462
ZNF670	-920	-5736
ZNF671	-2540	-680
ZNF677	-3143	-6476
ZNF678	-4108	530
ZNF681	-3034	-3353
ZNF684	-3341	-2033
ZNF688	-2575	-4023
ZNF689	-3330	-4943
ZNF691	-2067	-4147
ZNF692	-1428	-1190
ZNF696	-4504	-3058
ZNF70	-4592	-5340
ZNF700	-1424	-3707
ZNF701	-1059	-6116
ZNF703	-4045	-4320
ZNF706	-1867	-5848
ZNF707	-4368	-4401
ZNF708	-3475	-2881
ZNF709	-3111	-6445
ZNF710	2909	-6541
ZNF713	-1734	-3012
ZNF714	-985	-2480
ZNF717	-2945	-5768
ZNF736	-4506	-4463
ZNF737	-3596	-6022
ZNF74	-4690	-2918
ZNF740	-4355	878
ZNF746	3291	-3816
ZNF747	1377	-451
ZNF749	-3798	-5865
ZNF75A	-2525	-1824
ZNF761	-1788	-3885
ZNF764	-2191	-913
ZNF77	-4137	-489
ZNF771	-2493	-3926
ZNF772	-747	-5966
ZNF774	1767	-1078
ZNF775	1904	-4991
ZNF776	110	-3870
ZNF777	-2229	-4823
ZNF778	-3708	1050
ZNF782	-3127	128
ZNF785	-2244	-5042
ZNF786	-2189	56
ZNF79	-2977	470
ZNF790	-3832	-6139
ZNF791	-2443	-5116
ZNF792	-3008	645
ZNF793	-3375	-6557
ZNF799	-3666	-6025
ZNF839	-659	-6246
ZNF92	-3740	-2695
ZSCAN25	-3311	2482

---

---

Metabolism of RNA

Metabolism of RNA

metric	value
setSize	535
pMANOVA	6.68e-08
p.adjustMANOVA	2.68e-06
s.dist	0.153
s.RNA	-0.0918
s.meth	0.123
p.RNA	0.000355
p.meth	1.72e-06

Top 20 genes

Gene	RNA	meth
NOP14	-4022	2384
RNMT	-4139	2172
WDR77	-3675	2308
UPF3A	-3462	2175
RRP9	-3589	2034
RPL3	-2885	2313
SRSF7	-3031	2075
MTERF4	-4033	1559
RPL23A	-3334	1843
ADAT1	-3158	1883
NUP43	-3314	1617
EXOSC2	-4132	1269
NOL9	-3670	1426
FUS	-2274	2205
RPS11	-2332	2115
RPL13A	-2727	1802
TTC37	-2287	2107
FAM98B	-2732	1741
SRSF2	-1991	2284
SF3A3	-3953	1130

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
ACTB	4156	-4515
ADAR	-1029	-263
ADARB1	-1667	-6225
ADAT1	-3158	1883
ADAT2	-3526	-2393
ADAT3	347	1001
AKT1	1234	-1942
ALKBH8	-4457	-3991
ALYREF	2102	-4902
ANP32A	3747	-3737
AQR	574	-336
BMS1	-4492	-2552
BUD31	3007	776
BYSL	-1331	-88
C1D	1194	510
C2orf49	-1785	-443
CASC3	2005	-2580
CCAR1	-721	-2951
CCNH	243	-3754
CD2BP2	-635	-6240
CD44	3760	266
CDC40	2845	2242
CDC5L	2311	-5959
CDK7	1983	275
CDKAL1	-3155	-2998
CHERP	-1548	-2459
CLNS1A	366	-1163
CLP1	2730	-1417
CNOT1	-1273	-4543
CNOT10	-811	-361
CNOT11	663	-2236
CNOT3	2042	565
CNOT4	-399	-3064
CNOT6	1783	-3728
CNOT6L	-4229	-5686
CNOT7	-1154	349
CNOT8	3701	-2054
CPSF1	-1130	-6284
CPSF2	3459	-3164
CPSF3	2740	-4860
CPSF4	-3261	134
CRNKL1	1509	433
CSNK1D	760	-1777
CSNK1E	-3709	-4750
CSTF1	-1891	2021
CTNNBL1	480	-2232
CTU1	1699	-3154
CTU2	-3058	-2262
CWC15	-692	-4721
CWC22	261	-3308
CWC27	1621	2224
DCAF13	-1698	-2001
DCP1A	-1657	-2482
DCP1B	-4482	-5406
DCP2	2848	-2783
DCPS	-700	-1076
DDX1	-840	-558
DDX20	-4044	-3695
DDX21	1018	760
DDX23	-218	164
DDX42	7	-1996
DDX46	814	-2306
DDX47	-4257	-3056
DDX49	1815	-4408
DDX5	-3465	1288
DDX52	142	-1954
DDX6	-580	1106
DHX16	-1503	-3824
DHX37	-2753	-312
DHX9	322	871
DIS3	-1292	-762
DNAJC8	334	605
DUS2	1175	2247
EBNA1BP2	-1224	1600
EDC3	1313	-1960
EDC4	-1557	-5349
EFTUD2	3773	1095
EIF4A1	3303	-3762
EIF4A2	-4175	836
EIF4A3	3132	-3850
EIF4B	387	-4336
EIF4E	1789	1536
EIF4G1	3585	746
ELAC2	-4545	-916
ELAVL1	651	-6154
ENPP2	603	-2276
ERCC2	1210	-594
ERCC3	-2534	969
ERI1	2157	130
ETF1	3209	758
EXOSC1	-319	-290
EXOSC10	-4315	-1580
EXOSC2	-4132	1269
EXOSC3	161	-2555
EXOSC4	3305	-4410
EXOSC5	-1377	1591
EXOSC6	-3464	545
EXOSC7	-3889	-4665
EXOSC8	-4363	1020
FAM98B	-2732	1741
FAU	-124	-3862
FBL	-3651	-2611
FCF1	1633	-2675
FIP1L1	-2603	-2274
FTSJ3	-1200	-670
FUS	-2274	2205
FYTTD1	-1781	1459
GAR1	-2203	-4416
GCFC2	-3981	-2094
GEMIN2	-2496	-3548
GEMIN4	-4181	-6519
GEMIN5	-1560	-2833
GEMIN6	745	-1619
GEMIN7	1801	1324
GLE1	1950	829
GNL3	-2859	-1419
GSPT1	2672	-4456
GTF2F1	1854	-1723
GTF2F2	2104	-2885
GTF2H3	-672	1025
GTF2H4	-876	-2761
GTF2H5	1345	691
GTPBP3	-2334	-3838
HBS1L	1873	-598
HEATR1	-3738	-1985
HNRNPA0	-2960	460
HNRNPA2B1	1133	-2665
HNRNPC	2536	-1112
HNRNPD	902	-1374
HNRNPF	1366	-58
HNRNPH1	-2604	-1020
HNRNPK	3259	-2386
HNRNPL	-34	-741
HNRNPM	1976	-4945
HNRNPR	-2856	-4296
HNRNPU	928	-970
HNRNPUL1	935	-1966
HSPA1A	3613	-3825
HSPB1	582	-4137
IGF2BP3	2588	-4480
IMP3	-3288	99
IMP4	-4084	-2925
ISG20L2	1309	1893
ISY1	2281	-4700
KHSRP	866	-5005
KRR1	-2907	-6562
LCMT2	-3932	-441
LSM1	2464	515
LSM10	2585	-3871
LSM11	-3779	-4172
LSM2	860	-1678
LSM3	-133	-674
LSM4	-3824	-5491
LSM5	-1952	-3381
LSM6	3069	-1989
LSM7	-2063	-5454
LSM8	-3316	-2296
LTV1	-1284	-3205
MAPK14	4207	-3529
MAPKAPK2	1428	2012
METTL1	-2291	-5208
METTL14	-2292	-4236
MNAT1	-2935	311
MPHOSPH10	-2537	-57
MPHOSPH6	685	-5463
MRM1	-3829	-5990
MTERF4	-4033	1559
MTO1	-2811	-856
NCBP1	-1807	-3745
NCBP2	-3329	-4067
NCL	-3204	-2515
NDC1	-4789	-5228
NHP2	-1038	-260
NIP7	-1813	-1760
NOB1	-3724	-1000
NOC4L	-1668	1990
NOL11	-3807	-2629
NOL12	1851	505
NOL6	-4043	526
NOL9	-3670	1426
NOP10	3759	-3526
NOP14	-4022	2384
NOP2	-3530	-2438
NOP56	-4540	-523
NOP58	-3529	-2406
NSUN2	-570	65
NSUN4	-1451	-3469
NSUN6	-2512	-2844
NUDT21	-1100	13
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
NXF1	563	-162
NXT1	-2554	1069
PABPC1	2061	-2769
PABPN1	-169	-3743
PAIP1	927	241
PAN2	-1320	-1449
PAN3	2	-3562
PAPOLA	3065	775
PARN	-1591	-4138
PATL1	2054	-5336
PCBP1	3284	-1395
PCBP2	2027	132
PDCD11	-4401	-2174
PDCD7	-2408	-1270
PELP1	-4054	-1579
PES1	-609	-3908
PHAX	-1605	694
PLRG1	-2109	692
PNO1	-2170	-5495
PNRC2	-1366	-2821
POLDIP3	3131	-5416
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
POM121	-2766	-1787
POM121C	-2305	-4315
POP1	-1211	-517
POP4	-1125	2076
POP5	-3385	-4690
POP7	1464	466
PPIE	-3082	644
PPIH	-4434	-2541
PPIL1	-1715	-5540
PPIL3	-1533	-1459
PPIL4	995	-2414
PPIL6	85	1558
PPP2CA	3707	300
PPP2R2A	1461	-5074
PPWD1	-3767	513
PRCC	780	-2557
PRKCA	356	810
PRKCD	4154	584
PRMT5	1232	-2112
PRPF19	-3026	-2289
PRPF3	-2461	-5317
PRPF31	-2436	-4737
PRPF38A	-70	-2763
PRPF40A	898	2454
PRPF6	-2246	-2317
PRPF8	-2680	-1872
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTBP1	-68	-1843
PUF60	-270	1796
PUS1	-1988	-1746
PUS3	1246	-5241
PUS7	-1663	263
PWP2	-378	681
QTRT1	-3345	-3239
RAE1	1963	-39
RAN	-2142	1257
RANBP2	-273	-4704
RBM17	-1486	1681
RBM28	-4493	-685
RCL1	-244	-1421
RIOK1	-1131	-2098
RIOK2	300	-954
RIOK3	4013	-2443
RNGTT	1007	-2952
RNMT	-4139	2172
RNPC3	-1313	-1410
RNPS1	-4345	-3160
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPP14	974	-354
RPP21	-1631	-5256
RPP25	-2741	-5917
RPP30	-2675	-5522
RPP38	-2263	1598
RPP40	-1467	-1426
RPPH1	25	-5149
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
RRP1	-924	77
RRP7A	-846	-2961
RRP9	-3589	2034
RTCB	-461	-261
SART1	1259	218
SEC13	2266	-3749
SEH1L	-1875	-1615
SENP3	966	-1248
SET	-2218	-5937
SF1	-215	-1708
SF3A1	-726	-2997
SF3A2	-1608	2430
SF3A3	-3953	1130
SF3B2	568	-3350
SF3B3	-3425	-1675
SF3B4	708	984
SF3B5	1093	-4116
SKIV2L	-1017	-2116
SLBP	2050	-327
SLU7	871	-3467
SMG1	-1341	-3377
SMG5	2044	-4423
SMG6	-1937	1909
SMG7	2744	-589
SMG8	939	-3537
SMNDC1	2212	-3187
SNRNP200	-4136	-2478
SNRNP25	-33	2102
SNRNP27	2692	1474
SNRNP35	1678	-3130
SNRNP40	-3737	-1247
SNRNP48	-384	996
SNRNP70	-2059	-371
SNRPA	791	1121
SNRPA1	-3561	-3336
SNRPB	-718	-2182
SNRPB2	1056	-5774
SNRPC	234	-3668
SNRPD1	208	-1771
SNRPD2	-2510	1134
SNRPD3	518	1486
SNRPE	194	-919
SNRPG	512	-4002
SNRPN	-3514	-5234
SNU13	-2174	1961
SNUPN	2439	-2979
SNW1	1979	946
SRRM1	-1535	-2963
SRRM2	-853	2142
SRRT	-1601	-3758
SRSF10	-2779	1198
SRSF11	-3554	-5151
SRSF2	-1991	2284
SRSF3	-682	-121
SRSF4	1324	-2328
SRSF7	-3031	2075
SRSF9	3210	-3686
SUPT5H	-2108	-3641
SYF2	1899	-1707
SYMPK	-1895	-2815
TBL3	-1027	994
TEX10	-3427	-1947
TFB1M	-4290	-3739
TFIP11	151	-278
THADA	-4547	-3826
THG1L	-3813	-2349
THOC1	-3681	73
THOC5	3107	747
THOC7	2564	-369
THUMPD1	-3443	-4292
TNFSF13	3783	-5904
TNKS1BP1	-1672	-5457
TNPO1	1436	-1546
TP53RK	-4708	-2342
TPR	-2242	-973
TPRKB	-1590	-2506
TRDMT1	290	-4357
TRIT1	238	-2615
TRMT1	-1030	1178
TRMT10A	2892	-5299
TRMT11	-4226	-4066
TRMT112	233	-4666
TRMT12	-109	956
TRMT44	-2179	-1269
TRMT6	2240	1951
TRMT61A	-3328	-4239
TRMT61B	-2628	-2862
TRMU	-3201	-1879
TRNT1	-2449	-1006
TSEN15	-3498	-3075
TSEN2	-4059	-3251
TSEN34	3254	-751
TSEN54	-4841	-550
TSR1	-3410	-3041
TSR3	1337	1167
TTC37	-2287	2107
TXNL4A	2929	-1664
TYW1	-3175	-820
TYW3	-2782	-4913
TYW5	-381	485
U2AF1	398	-5640
U2AF1L4	-1283	2171
U2AF2	1256	-306
U2SURP	-1927	-4877
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UPF1	1731	-630
UPF2	307	-1572
UPF3A	-3462	2175
URM1	-360	-3584
USP39	1448	117
UTP15	-3872	-2796
UTP18	1940	-3819
UTP20	-3834	-1372
UTP3	-874	-3665
UTP6	-1347	-1904
WBP11	-4480	-1693
WBP4	2071	-3514
WDR12	1988	706
WDR18	-691	-2042
WDR3	-2064	-5710
WDR33	-2506	-3224
WDR36	-1177	-2277
WDR43	-2494	-4225
WDR61	22	-4752
WDR75	-3509	1028
WDR77	-3675	2308
WTAP	1550	-525
XAB2	-567	-1877
XPO1	-371	-870
XPOT	-809	-828
XRN1	-2146	-5555
XRN2	4366	-5589
YBX1	1010	-364
YWHAB	2611	2125
YWHAZ	2200	541
ZBTB8OS	1520	-1338
ZCRB1	150	2291
ZFP36	2933	1924
ZFP36L1	2944	784
ZMAT5	2765	-6365

---

---

Metabolism of lipids

Metabolism of lipids

metric	value
setSize	427
pMANOVA	7.26e-08
p.adjustMANOVA	2.81e-06
s.dist	0.164
s.RNA	0.164
s.meth	-0.00959
p.RNA	9.91e-09
p.meth	0.737

Top 20 genes

Gene	RNA	meth
GGT1	4376	-6607
TSPO	4344	-6553
PTGR1	4217	-6711
ARF1	4184	-6686
TBXAS1	4073	-6709
PRKACA	4378	-6032
PLD1	4321	-6058
ALOX5	4150	-6082
CHPT1	4062	-5900
GPX1	4327	-5467
PNPLA2	4111	-5698
ALOX5AP	3490	-6710
PGS1	3952	-5906
VAPA	4169	-5592
PLB1	4405	-5279
GBA	4133	-5623
HEXB	4022	-5777
FIG4	4210	-5382
GLTP	3852	-5867
LPGAT1	3906	-5760

Click HERE to show all gene set members

All member genes

	RNA	meth
AACS	105	843
ABCA1	2459	-6487
ABCC1	179	-871
ABHD3	2932	-4046
ABHD4	2638	-5841
ABHD5	3512	-5560
ACAA1	3734	1410
ACACA	2039	-164
ACACB	-3532	-4884
ACAD10	1792	-83
ACAD11	-3656	-2327
ACADM	-404	-2163
ACADS	1543	-6188
ACAT1	2158	-2579
ACAT2	-1106	-2151
ACBD4	-1346	-2973
ACBD5	-398	-2520
ACBD6	-4143	-1414
ACBD7	1102	-5886
ACER2	654	-2800
ACER3	4240	-1641
ACLY	1961	-5417
ACOT13	2098	-3113
ACOT7	-981	1021
ACOT8	3578	-2563
ACOX1	4070	-5075
ACOX3	2397	-4725
ACOXL	1769	2527
ACP6	-1122	-5222
ACSF2	-4243	-5644
ACSF3	-119	-5695
ACSL1	4266	-1604
ACSL3	3461	-4285
ACSL5	-3830	-215
ACSL6	-1821	2501
ACSM3	-2384	-6252
AGK	-4757	-3004
AGPAT1	3663	559
AGPAT2	4289	2250
AGPAT3	1787	-2039
AGPAT4	-2892	-4185
AGPAT5	-3512	221
AGPS	2135	-3742
AHR	3240	2099
AHRR	-1770	-702
AKR1B1	-4638	1845
ALDH3A2	264	-2186
ALOX5	4150	-6082
ALOX5AP	3490	-6710
AMACR	-2220	-663
ARF1	4184	-6686
ARF3	3396	-1912
ARNT	3596	1140
ARNTL	-2150	-4129
ARSA	1183	-3099
ARSB	3290	-5722
ARSG	-1448	152
ARSK	-4182	-54
ARV1	-813	-2677
ASAH1	3880	335
BDH1	-3780	-5778
BDH2	-4379	-6434
CAV1	619	-2432
CBR4	-388	-2264
CCNC	589	-1138
CDIPT	2525	-2467
CDK19	3319	-2575
CDK8	-594	-5509
CDS2	2711	979
CEPT1	353	289
CERK	-1598	1601
CERS5	-758	-6266
CERS6	2291	-3796
CHD9	-1380	-5791
CHKA	2436	-4562
CHKB	-992	816
CHPT1	4062	-5900
CLOCK	-2411	-1159
CPNE1	-1012	1274
CPNE3	2335	-2088
CPT1A	1921	-6398
CPT2	2700	-6494
CPTP	1249	-2096
CRAT	4098	-4890
CREBBP	1153	-5804
CRLS1	4211	-4654
CSNK1G2	284	-1639
CSNK2A2	2614	-4422
CSNK2B	1389	-998
CTSA	4412	-4847
CYP2R1	-3508	-1915
CYP2U1	-4687	-4531
CYP46A1	-188	1529
CYP4F22	-4840	-2371
CYP51A1	2876	-5191
DBI	2529	441
DDHD1	-4459	1414
DDHD2	-4582	-2861
DECR1	2037	-528
DECR2	247	830
DEGS1	2496	-193
DGAT1	2033	-6115
DGAT2	4236	-1911
DHCR24	858	-5657
DHCR7	2784	-3544
DHRS7B	3327	-3549
DPEP2	-808	-6530
ECHS1	-676	-1673
ECI1	149	-4832
ECI2	-4551	-2127
EHHADH	2477	-6438
ELOVL1	3022	-1168
ELOVL4	-2134	-2987
ELOVL5	2406	-3408
ELOVL6	-4374	-1124
EP300	2471	-4509
EPHX2	-3649	-5989
ESRRA	2372	-2927
ESYT1	-4827	959
ESYT2	-4484	-1193
ETNK1	-436	1286
FABP5	2411	-3534
FADS1	3374	-4312
FADS2	458	-5605
FAM120B	-4	-2607
FAR1	4009	-224
FASN	-223	1100
FDFT1	3180	-4585
FDPS	2049	124
FDX1	579	-3747
FDXR	1776	-3448
FIG4	4210	-5382
FITM2	-1868	-2082
GALC	3834	264
GBA	4133	-5623
GBA2	957	-4419
GDE1	3946	-5040
GDPD1	-1367	-1268
GDPD5	-3955	-2713
GGPS1	-339	-2782
GGT1	4376	-6607
GLB1	3992	1368
GLIPR1	3403	-2351
GLTP	3852	-5867
GM2A	4180	-825
GPAM	-3683	-4630
GPCPD1	3878	-203
GPD1	-2182	-6250
GPD1L	-3809	-2487
GPD2	3277	-6521
GPS2	-293	-857
GPX1	4327	-5467
GPX4	1957	-455
GSTM4	370	-4359
HACD1	1663	-4245
HACD2	-520	1513
HACD3	-4020	2329
HACD4	2893	500
HACL1	-4541	-3683
HADH	-4341	-4809
HADHA	3974	1866
HADHB	4389	-968
HDAC3	1727	-3771
HEXA	391	-4273
HEXB	4022	-5777
HILPDA	-485	670
HMGCL	2059	1969
HMGCR	3626	-3388
HMGCS1	-595	-2608
HPGD	3208	-6446
HSD17B1	1250	1940
HSD17B11	3570	-3328
HSD17B12	3082	-895
HSD17B4	4069	-5528
HSD17B8	-3941	2077
IDI1	3116	1929
INPP4A	-3365	2209
INPP5D	-1207	-3735
INPP5E	-2803	2080
INPP5F	-1476	507
INPP5K	-610	1585
INPPL1	4166	-2224
INSIG1	-3893	947
INSIG2	2643	-4256
KPNB1	776	-2176
LBR	3631	-3506
LCLAT1	-59	-2733
LGMN	-1401	313
LIPE	-3191	-5437
LPCAT1	-2399	1540
LPCAT3	3925	-3100
LPCAT4	-2836	1628
LPGAT1	3906	-5760
LPIN1	-4350	-2651
LPIN2	-2200	2060
LSS	-3858	-4805
LTA4H	4292	-972
LTC4S	-121	-6617
MAPKAPK2	1428	2012
MBOAT1	2139	-4287
MBOAT7	3885	-3703
MBTPS1	955	-398
MCAT	2113	-3215
MCEE	-1430	320
MECR	-2366	350
MED1	-1206	-2271
MED10	-2893	-2572
MED11	-181	609
MED13	807	590
MED13L	2440	-533
MED15	-3434	2114
MED16	2024	1719
MED17	1004	-1418
MED18	1590	-186
MED19	1074	-4664
MED20	2814	-542
MED21	-1826	-582
MED22	1321	-2059
MED23	-2139	633
MED24	-2380	-2701
MED25	2518	-1286
MED26	1589	18
MED27	-3167	-960
MED28	-445	699
MED29	-2631	-5128
MED30	-1669	491
MED31	447	445
MED4	1062	-4472
MED6	-279	560
MED7	62	778
MED8	3267	1289
MED9	-2996	-3399
MFSD2A	-690	-5062
MLYCD	-3346	97
MMAA	-4375	-3965
MORC2	-3367	2508
MSMO1	818	1922
MTF1	4102	-2992
MTMR10	3542	-3555
MTMR12	-513	-579
MTMR14	3586	-4278
MTMR2	-664	519
MTMR3	4187	-2340
MTMR4	951	-1420
MTMR6	3487	1477
MTMR9	443	-2578
MVD	-1805	1954
MVK	-2769	-2474
NCOA2	343	1407
NCOA3	1198	-2266
NCOA6	2280	-1860
NCOR1	2341	-3738
NCOR2	3557	-4281
NDUFAB1	2272	-395
NEU1	4167	-3878
NEU3	-1138	-1409
NFYA	1189	1464
NFYB	-3536	-531
NFYC	3345	-3078
NR1D1	-3070	1187
NR1H2	3207	-1471
NR1H3	-1069	-2305
NRF1	-2712	-4642
NUDT19	2682	1908
NUDT7	341	593
ORMDL1	-1831	-584
ORMDL3	-3550	-2716
OSBP	-792	-3696
OSBPL2	1941	-2911
OSBPL3	-4657	375
OSBPL5	-4802	-6730
OSBPL7	-4536	-4735
OSBPL8	2939	-2735
OSBPL9	2623	-2108
OXCT1	-4509	1553
PCCB	-2627	-6219
PCTP	4357	-3451
PCYT1A	2857	822
PCYT2	-4291	-2669
PECR	4000	2064
PEMT	1014	-4605
PEX11A	-2998	-2595
PGS1	3952	-5906
PHOSPHO1	947	-430
PI4K2A	-2085	-355
PI4K2B	-4673	-317
PI4KA	-782	-5
PI4KB	-1333	1292
PIAS4	1971	-3982
PIK3CA	1703	-1445
PIK3CD	2422	2189
PIK3CG	569	-2045
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R3	-4692	-22
PIK3R4	-1215	-3425
PIK3R5	-688	514
PIKFYVE	1048	-2382
PIP4K2A	-707	1772
PIP4K2B	-2535	-6347
PIP4K2C	-4309	-5573
PIP5K1A	2460	-348
PIP5K1C	1151	-5383
PISD	4093	-4659
PITPNB	-2252	-4909
PITPNM1	2289	873
PITPNM2	-1464	2520
PITPNM3	-1020	1888
PLA2G12A	2244	-5029
PLA2G15	4005	-3722
PLA2G4C	-859	-4912
PLA2G6	-4758	-3132
PLB1	4405	-5279
PLD1	4321	-6058
PLD3	3177	1541
PLD6	-1150	2227
PLEKHA2	-419	-4384
PLEKHA3	-1543	-6547
PLEKHA6	-528	-2325
PLEKHA8	-923	-1764
PLIN2	3718	-96
PLIN3	4385	-3203
PMVK	1104	1829
PNPLA2	4111	-5698
PNPLA6	2889	-3173
PNPLA7	-2176	-1431
PNPLA8	3379	-3836
PON2	-1901	-4741
PPARD	-1990	660
PPARGC1B	-1534	1840
PPM1L	-1031	-4324
PPP1CA	1435	550
PPP1CB	3004	1839
PPP1CC	2581	-754
PPT1	4119	-4371
PPT2	-4288	-5624
PRKAB2	-2709	-1428
PRKACA	4378	-6032
PRKACB	-4656	455
PRKAG2	636	-5033
PRKD2	-3006	229
PSAP	3061	-4192
PTDSS2	2331	-1185
PTEN	3844	-1100
PTGES2	-2198	-1462
PTGES3	1450	-1810
PTGR1	4217	-6711
PTGR2	385	-3930
PTPMT1	693	414
PTPN13	-3534	-6489
RAB14	3027	1334
RAB4A	3532	-5479
RAB5A	3035	-1686
RAN	-2142	1257
RGL1	3340	1731
RORA	-4672	2287
RUFY1	2621	-4178
SACM1L	-3188	-1578
SAMD8	3315	-5347
SAR1B	2676	489
SBF1	-3835	882
SC5D	-1097	-6658
SCAP	-1253	-3851
SCD	1416	-6126
SCP2	1625	-5793
SEC23A	3162	-5141
SEC24A	3350	61
SEC24B	1233	-5505
SEC24C	-768	805
SEC24D	3637	-3966
SGMS1	4025	-1653
SGPL1	1110	-2339
SGPP1	-4810	-5414
SIN3A	-3818	-4151
SIN3B	-1256	570
SLC22A5	2925	-5659
SLC25A1	1857	-910
SLC25A17	-3849	-4326
SLC25A20	1381	2245
SLC27A1	3744	-3528
SLC27A2	-1137	-6055
SLC27A3	-258	-1585
SLC27A5	-1076	-3060
SLC44A1	3877	2368
SLC44A2	861	2003
SMPD1	355	-28
SMPD2	793	-918
SMPD3	-4824	2463
SP1	3686	-3141
SPHK2	914	-2294
SPTLC1	3914	-5493
SPTLC2	3893	743
SPTLC3	581	1742
SPTSSA	1715	-5079
SQLE	1494	-5831
SRD5A1	3535	2146
SRD5A3	1390	442
SREBF1	2701	-4015
SREBF2	2792	-1852
STARD10	1786	-337
STARD3	1116	-5163
STARD3NL	3182	-4610
STARD4	-1221	-2360
STARD5	-883	-5368
STARD7	1146	-1506
SUMF1	4144	-5376
SUMF2	-4706	-3692
SYNJ1	2565	1501
SYNJ2	-2867	-6043
TBL1XR1	1669	962
TBXAS1	4073	-6709
TECR	-3264	-274
THEM4	-4130	-6129
TIAM2	-4087	-1035
TM7SF2	-2418	-1255
TNFAIP8	-152	1226
TNFAIP8L1	-3518	-4062
TNFAIP8L2	2226	-249
TRIB3	-1802	1669
TSPO	4344	-6553
TXNRD1	3685	-4647
UBE2I	-245	233
UGCG	2541	1914
VAC14	-38	-2381
VAPA	4169	-5592
VAPB	687	-6771
VDR	3768	-3651

---

---

Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication

metric	value
setSize	110
pMANOVA	7.6e-08
p.adjustMANOVA	2.85e-06
s.dist	0.33
s.RNA	-0.224
s.meth	0.242
p.RNA	5.08e-05
p.meth	1.27e-05

Top 20 genes

Gene	RNA	meth
IPO5	-3864	1869
RPL3	-2885	2313
RPL23A	-3334	1843
NUP43	-3314	1617
RPS11	-2332	2115
RPL13A	-2727	1802
RPL32	-2103	1928
NUP210	-3943	910
NUP205	-4274	826
RPS2	-1344	2392
NUP160	-3847	763
RPL35	-2671	952
RPL4	-1064	2321
RPS10	-1780	1246
RPS15	-1095	1808
RPS15A	-1762	1086
RPL17	-1654	1099
RPS3A	-1419	1275
POLR2H	-882	1944
NUP153	-1967	834

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
DNAJC3	3828	-2353
FAU	-124	-3862
GRSF1	1966	27
GTF2F1	1854	-1723
GTF2F2	2104	-2885
HSP90AA1	411	-781
IPO5	-3864	1869
NDC1	-4789	-5228
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
PARP1	-4548	-5521
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
POM121	-2766	-1787
POM121C	-2305	-4315
RAE1	1963	-39
RANBP2	-273	-4704
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
SEC13	2266	-3749
SEH1L	-1875	-1615
TPR	-2242	-973
UBA52	349	752

---

---

Cellular responses to stress

Cellular responses to stress

metric	value
setSize	452
pMANOVA	8.05e-08
p.adjustMANOVA	2.92e-06
s.dist	0.152
s.RNA	0.116
s.meth	0.0986
p.RNA	3.01e-05
p.meth	0.000397

Top 20 genes

Gene	RNA	meth
MAP4K4	3823	2014
PHC2	4171	1830
DNAJB6	3609	1923
ATP6V1A	4318	1580
ATP6V0B	3921	1604
LAMTOR2	3287	1882
MAPK1	3249	1865
BAG1	2618	2301
CUL3	2861	2054
PSMA7	3028	1752
PSMD1	3112	1660
CBX8	2112	2207
FOS	2120	2149
AGO1	2217	1997
UBE2S	1766	2449
PRDX3	4351	972
PSME3	3715	1116
ARNT	3596	1140
DNAJA2	2185	1824
NUP214	3517	1119

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
ABCC1	179	-871
ACD	-2542	-5810
ACTR10	3309	-1291
ACTR1A	2965	-1
AGO1	2217	1997
AGO3	-324	-6442
AJUBA	-2602	-2301
AKT1S1	3477	-2319
ANAPC1	-4659	403
ANAPC10	-1520	-6111
ANAPC11	2490	344
ANAPC15	4132	-1379
ANAPC16	-640	-4507
ANAPC2	-2390	-1007
ANAPC4	-2075	-1696
ANAPC5	-4080	-2530
ANAPC7	-1573	1560
ARNT	3596	1140
ARNTL	-2150	-4129
ASNS	-2775	12
ATF3	-3386	-4121
ATF4	2535	-956
ATF5	-1618	-722
ATM	-4170	202
ATOX1	1562	-5343
ATP6V0B	3921	1604
ATP6V0C	4218	-4697
ATP6V0D1	4282	-1003
ATP6V0E1	3919	-2865
ATP6V0E2	-4420	-6625
ATP6V1A	4318	1580
ATP6V1B2	4178	-4232
ATP6V1C1	3887	655
ATP6V1D	4174	-1234
ATP6V1E1	3588	-3948
ATP6V1F	2338	1350
ATP6V1G2	-3312	-3714
ATP6V1H	3607	-1695
ATR	-3743	970
BACH1	4212	210
BAG1	2618	2301
BAG2	-2637	-2208
BAG3	-948	423
BAG4	3756	-3089
BAG5	-1481	-4477
BLVRA	2273	1170
BLVRB	4360	-5026
BMI1	-3460	-6383
C12orf66	-4076	-3658
CABIN1	-3863	-2517
CAMK2D	-4581	-2867
CAMK2G	601	2354
CAPZA1	3648	572
CAPZA2	3920	-36
CAPZB	3576	-4065
CAT	4214	-3922
CBX4	699	-5288
CBX6	1421	-3511
CBX8	2112	2207
CCAR2	-3633	2391
CCNA2	520	-1132
CCNE1	-4514	-3403
CCNE2	1953	-3396
CCS	471	102
CDC16	-1877	-4152
CDC23	-4259	-707
CDK2	-1522	1018
CDK4	-4235	-1295
CDK6	-2015	-2864
CDKN1A	1646	-3540
CDKN1B	-2723	-862
CDKN2A	-1595	-4511
CDKN2C	2853	-130
CDKN2D	3469	308
CEBPB	3564	-5089
CEBPG	2122	1702
CHD9	-1380	-5791
CITED2	2659	-104
CLOCK	-2411	-1159
COX11	-4412	-789
COX14	-471	-3835
COX16	34	-1160
COX19	-2178	-4047
COX20	-1527	-4841
COX4I1	1484	-5506
COX5A	2495	-2944
COX5B	2517	382
COX6A1	1930	-961
COX6B1	2224	-2634
COX6C	220	-1411
COX7A2L	3386	-2476
COX7C	176	-4071
COX8A	2745	-1258
CREB1	-430	-672
CREBBP	1153	-5804
CRTC1	-15	-728
CRTC2	26	1184
CRTC3	66	-3688
CSNK2A2	2614	-4422
CSNK2B	1389	-998
CUL1	-4281	-5146
CUL2	805	-1212
CUL3	2861	2054
CYBA	2922	1006
CYCS	-411	-3927
DCTN2	4235	-6011
DCTN3	2396	-4272
DCTN4	3796	-2073
DCTN5	-1222	-5100
DCTN6	3145	819
DDIT3	1831	-3177
DEDD2	1107	1927
DEPDC5	28	-4322
DNAJA1	2099	-1834
DNAJA2	2185	1824
DNAJA4	-291	2305
DNAJB1	-1737	-3687
DNAJB6	3609	1923
DNAJC2	-1507	-1772
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNLL1	2378	-3319
DYNLL2	-1189	214
E2F1	2589	-1005
E2F2	3922	386
E2F3	2768	-2884
EED	-3235	-1174
EEF1A1	-1549	720
EGLN1	2741	-6231
EGLN2	1221	-3619
EHMT1	-2937	-1697
EHMT2	-2883	-1059
EIF2AK1	3854	1012
EIF2AK4	11	-5466
EIF2S1	1532	-4266
EIF2S2	2500	-783
EP300	2471	-4509
EP400	-2038	1434
EPAS1	3494	535
ERF	1594	-683
ERO1A	4115	-4535
ETS1	-4320	2277
ETS2	3624	-5483
EZH2	-3415	-20
FAU	-124	-3862
FBXL17	-1827	-2422
FKBP4	263	-4442
FKBP5	4199	-5653
FLCN	1237	708
FNIP1	2191	355
FOS	2120	2149
FZR1	-670	-758
GCN1	-3759	-6714
GPX1	4327	-5467
GRB10	4386	-70
GSK3B	2756	736
GSR	4276	-4724
GSTP1	35	-5415
HDAC3	1727	-3771
HIF1A	3219	-3349
HIF1AN	-1348	-1051
HIGD1A	3194	-4744
HIRA	-3362	-860
HM13	3644	-3925
HMGA1	32	802
HMOX2	-4583	2130
HSBP1	3674	-3338
HSF1	2428	1452
HSP90AA1	411	-781
HSP90AB1	-2171	-5745
HSPA13	-364	-1732
HSPA14	-3248	866
HSPA1A	3613	-3825
HSPA1B	2669	-513
HSPA1L	1013	885
HSPA2	3017	-271
HSPA4	2060	963
HSPA4L	-884	-5898
HSPA9	-3436	-200
HSPH1	-3256	993
ID1	1843	-3980
ITFG2	-3938	-873
JUN	1286	69
KAT5	405	-650
KDM6B	3909	-92
KEAP1	1826	-2872
KPTN	2550	1279
LAMTOR1	4371	-5950
LAMTOR2	3287	1882
LAMTOR3	3292	321
LAMTOR4	1619	-6150
LAMTOR5	3865	-5095
LIMD1	-3980	-6080
LMNB1	4342	-942
LRPPRC	-3590	-5728
MAFK	288	-2942
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAP3K5	3365	-4989
MAP4K4	3823	2014
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPK8	-3265	6
MAPK9	-2259	872
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MDM2	1551	-1318
MDM4	-385	-2440
MED1	-1206	-2271
MEF2D	-929	-3018
MINK1	1269	-4004
MIOS	1132	561
MLST8	117	287
MOV10	-4681	-6449
MRPL18	675	-1383
MTOR	-3429	-1813
NBN	717	750
NCF4	4298	-6732
NCOA2	343	1407
NCOA6	2280	-1860
NCOR1	2341	-3738
NCOR2	3557	-4281
NDC1	-4789	-5228
NDUFA4	2661	288
NFE2L2	2808	-1441
NLRP3	4089	-6357
NPRL2	-4453	2371
NPRL3	1645	2138
NR1D1	-3070	1187
NR3C1	162	-2420
NR3C2	-3885	324
NUDT2	963	-2046
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
P4HB	3831	-1549
PHC1	-2820	-5180
PHC2	4171	1830
PHC3	-2698	1805
POM121	-2766	-1787
POM121C	-2305	-4315
PPP1R15A	2389	-5399
PRDX1	2981	-877
PRDX2	1157	-5158
PRDX3	4351	972
PRDX5	3882	-1661
PRDX6	4109	916
PRKCD	4154	584
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTGES3	1450	-1810
RAD50	-2373	2067
RAE1	1963	-39
RAI1	-1577	-2874
RANBP2	-273	-4704
RB1	3985	-4740
RBBP4	-565	-3282
RBX1	1368	-3241
RELA	-542	2085
RHEB	3356	-2334
RING1	-1216	-1490
RNF2	1192	-1936
RORA	-4672	2287
RPA1	-4688	-2495
RPA3	-3040	-1890
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS19BP1	863	436
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
RPTOR	-3804	2134
RRAGA	2539	-1657
RRAGC	1856	-2585
RRAGD	4008	-6311
SCMH1	-1799	1397
SCO1	-3455	-1715
SCO2	-1303	-4657
SEC13	2266	-3749
SEH1L	-1875	-1615
SERPINH1	-3616	-1891
SESN1	-3059	-3887
SESN2	1099	-3423
SIN3A	-3818	-4151
SIN3B	-1256	570
SIRT1	-1254	-1775
SKP1	1536	-2290
SKP2	-2759	-1566
SLC38A9	906	-3360
SOD1	-1475	-1019
SOD2	1587	573
SP1	3686	-3141
ST13	-390	-5101
STAT3	3628	-3606
STIP1	-632	31
SURF1	1204	-4976
SZT2	-1622	-5754
TACO1	1600	-5534
TBL1XR1	1669	962
TCIRG1	3087	-5082
TERF1	-1070	-1932
TERF2	-1332	982
TERF2IP	1903	-4579
TFDP1	3849	-1587
TFDP2	-4891	-4793
TINF2	1687	-1513
TNIK	-4494	-2132
TNRC6A	-1710	-5420
TNRC6B	-1353	2270
TP53	-4034	-739
TPR	-2242	-973
TRIB3	-1802	1669
TXN	3732	284
TXN2	1714	-257
TXNIP	-3347	-2777
TXNRD1	3685	-4647
TXNRD2	3261	-5499
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2C	1933	1091
UBE2D1	4255	-1581
UBE2D2	1717	-3799
UBE2D3	3944	-373
UBE2E1	2822	-5882
UBE2S	1766	2449
UBN1	2066	-3899
VCP	2902	-2411
VEGFA	3235	-2723
VHL	1262	1389
WDR24	361	-6152
WDR59	-3189	-1721
XPO1	-371	-870
YWHAE	4173	-4168

---

---

Signaling by NOTCH

Signaling by NOTCH

metric	value
setSize	130
pMANOVA	1.41e-07
p.adjustMANOVA	4.96e-06
s.dist	0.286
s.RNA	0.286
s.meth	-0.00581
p.RNA	2.07e-08
p.meth	0.909

Top 20 genes

Gene	RNA	meth
PLXND1	3238	-6504
PSMD6	3465	-5488
TACC3	4334	-4182
PSMD4	3806	-4683
PSMC1	2977	-5705
MAML3	4123	-4054
PSMB5	3630	-4604
NCSTN	4254	-3821
HDAC4	4126	-3817
NCOR2	3557	-4281
PSMC6	2757	-5508
ST3GAL6	2794	-5427
TLE3	3898	-3798
PSMF1	2775	-4867
RUNX1	3262	-4082
HDAC7	2465	-4900
PSEN1	3540	-3407
ST3GAL4	2285	-4996
MAML1	2088	-5348
EP300	2471	-4509

Click HERE to show all gene set members

All member genes

	RNA	meth
ACTA2	-143	-3190
ADAM10	4030	976
ADAM17	3634	774
AGO1	2217	1997
AGO2	967	2447
AGO3	-324	-6442
AKT1	1234	-1942
APH1A	1453	-6066
APH1B	2555	2056
ARRB1	632	-6363
ARRB2	3860	-2243
ATP2A1	-1409	-4587
ATP2A2	3591	1489
ATP2A3	-299	1190
B4GALT1	1540	-160
CCNC	589	-1138
CCND1	-2214	-6213
CDK8	-594	-5509
CREB1	-430	-672
CREBBP	1153	-5804
CUL1	-4281	-5146
DLGAP5	1015	-2706
DTX4	2486	1530
E2F1	2589	-1005
E2F3	2768	-2884
EP300	2471	-4509
FBXW7	-2055	-5428
FURIN	4191	2351
HDAC1	184	-1016
HDAC10	721	-1304
HDAC11	1771	-3595
HDAC2	2129	-46
HDAC3	1727	-3771
HDAC4	4126	-3817
HDAC5	1746	-3144
HDAC7	2465	-4900
HEY2	-3420	2330
HIF1A	3219	-3349
IKZF1	-2501	1828
ITCH	407	-1366
JUN	1286	69
KAT2A	-3970	-5050
KAT2B	-722	-1588
LFNG	-2806	1932
MAML1	2088	-5348
MAML2	-189	-2078
MAML3	4123	-4054
MFNG	-1854	-3250
MIB1	-896	-2718
MOV10	-4681	-6449
NBEA	-227	-6575
NCOR1	2341	-3738
NCOR2	3557	-4281
NCSTN	4254	-3821
NOTCH1	1743	1722
NOTCH4	-1593	-6455
NUMB	4372	-35
PLXND1	3238	-6504
POFUT1	646	973
PRKCI	-43	-4275
PSEN1	3540	-3407
PSEN2	-2508	-5155
PSENEN	2260	-3620
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSMF1	2775	-4867
RAB6A	3657	-311
RBPJ	4017	-1118
RBX1	1368	-3241
RPS27A	-2201	-2138
RUNX1	3262	-4082
SEL1L	2877	-2307
SIRT6	2520	-4139
SKP1	1536	-2290
SMAD3	-4538	-4628
SNW1	1979	946
ST3GAL3	158	-1055
ST3GAL4	2285	-4996
ST3GAL6	2794	-5427
STAT1	-4529	2195
TACC3	4334	-4182
TBL1XR1	1669	962
TFDP1	3849	-1587
TFDP2	-4891	-4793
TLE2	-2409	-3959
TLE3	3898	-3798
TLE4	2883	635
TMED2	2424	-3656
TNRC6A	-1710	-5420
TNRC6B	-1353	2270
TP53	-4034	-739
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
WWP2	3574	-718
YBX1	1010	-364
YWHAZ	2200	541

---

---

Signaling by NTRKs

Signaling by NTRKs

metric	value
setSize	90
pMANOVA	1.75e-07
p.adjustMANOVA	5.99e-06
s.dist	0.334
s.RNA	0.325
s.meth	0.0762
p.RNA	1.07e-07
p.meth	0.213

Top 20 genes

Gene	RNA	meth
CLTC	4149	2477
FURIN	4191	2351
PPP2CB	3381	1797
MAPK1	3249	1865
YWHAB	2611	2125
RHOA	3753	1313
FOS	2120	2149
RAC1	4031	971
FOSL1	4028	737
MAPKAPK2	1428	2012
DNM2	2448	738
RIT1	4213	337
PPP2CA	3707	300
RAP1A	3148	323
REST	276	2128
KIDINS220	3009	189
KRAS	1276	440
NELFB	115	1822
AP2M1	3936	20

Click HERE to show all gene set members

All member genes

	RNA	meth
ADORA2A	1094	-5935
AP2A1	2869	-4887
AP2M1	3936	20
AP2S1	3581	-3262
ATF1	2245	-2565
BAX	2357	-3623
BRAF	403	-4347
CDK5	3929	-506
CDK5R1	-346	-2113
CHD4	-1351	-4634
CLTA	3788	-5077
CLTC	4149	2477
CREB1	-430	-672
CRK	4091	-4581
CRKL	1387	-906
DNAL4	1142	-45
DNM1	1225	-5619
DNM2	2448	738
DUSP3	4305	-1798
DUSP4	-1957	-3176
DUSP6	1570	-6763
DUSP7	-960	-1322
EGR1	1023	-163
EGR2	-450	-2628
EP300	2471	-4509
FOS	2120	2149
FOSB	418	-332
FOSL1	4028	737
FRS2	-1025	-1999
FRS3	3166	-2329
FURIN	4191	2351
FYN	-4495	1957
GRB2	4320	-2295
HRAS	-1008	-4780
ID1	1843	-3980
ID2	-4082	566
ID3	-3355	1995
IRS1	533	-4060
IRS2	3903	-5410
JUNB	2850	-3031
JUND	478	-1239
KIDINS220	3009	189
KRAS	1276	440
LYL1	3697	-6435
MAP2K1	4183	-698
MAP2K2	2840	-3962
MAP2K5	1370	-3572
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MEF2A	3571	-2822
MEF2D	-929	-3018
NAB1	416	-2731
NAB2	-3772	989
NELFB	115	1822
NTRK1	-2715	898
PCSK5	1812	-4883
PIK3CA	1703	-1445
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PLCG1	-4158	-3541
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5D	771	-4349
PTPN11	2038	-2302
RAC1	4031	971
RALA	864	-262
RALB	3814	-1081
RALGDS	-4770	1254
RAP1A	3148	323
RAPGEF1	-3458	1868
REST	276	2128
RHOA	3753	1313
RIT1	4213	337
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA5	-4445	-514
SGK1	1689	-6076
SHC1	1472	-2954
SOS1	-1748	-6775
SRC	-2999	-4427
SRF	3015	-1284
STAT3	3628	-3606
TCF12	-386	-4702
VRK3	396	-1398
YWHAB	2611	2125

---

---

Interleukin-1 signaling

Interleukin-1 signaling

metric	value
setSize	78
pMANOVA	2.35e-07
p.adjustMANOVA	7.79e-06
s.dist	0.36
s.RNA	0.36
s.meth	0.0153
p.RNA	4.21e-08
p.meth	0.815

Top 20 genes

Gene	RNA	meth
NOD2	3833	1528
TAB2	2942	1892
PSMA7	3028	1752
PSMD1	3112	1660
CHUK	3543	1343
PSME3	3715	1116
MAP3K8	2489	1442
PSMD12	2710	1314
PSMB2	1439	2355
NFKBIA	2851	1159
PSMD13	2376	1328
PSMA2	2052	1205
UBE2N	607	1127
UBA52	349	752
MAP3K3	3850	64
PSMD7	2383	7

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4249	-5300
BTRC	-1493	-2427
CHUK	3543	1343
CUL1	-4281	-5146
FBXW11	2510	-6747
HMGB1	-86	-1263
IKBKB	-1640	-3894
IL1RAP	3063	-456
IRAK2	-3327	-1457
IRAK3	4208	-6295
MAP2K1	4183	-698
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP3K3	3850	64
MAP3K7	761	-2089
MAP3K8	2489	1442
MYD88	3649	-1927
NFKB2	-367	388
NFKBIA	2851	1159
NFKBIB	-48	-3368
NKIRAS1	116	-3490
NKIRAS2	4346	-5039
NOD1	-4837	-5170
NOD2	3833	1528
PELI1	2800	-3839
PELI2	3750	-2561
PELI3	3383	-4323
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
RBX1	1368	-3241
RELA	-542	2085
RPS27A	-2201	-2138
SKP1	1536	-2290
SQSTM1	1438	-952
TAB2	2942	1892
TNIP2	2166	-5726
TOLLIP	3905	-5037
TRAF6	-80	-6118
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2N	607	1127
UBE2V1	2209	-1021

---

---

Influenza Infection

Influenza Infection

metric	value
setSize	128
pMANOVA	2.54e-07
p.adjustMANOVA	8.2e-06
s.dist	0.294
s.RNA	-0.184
s.meth	0.23
p.RNA	0.00034
p.meth	7.89e-06

Top 20 genes

Gene	RNA	meth
ISG15	-4701	1894
IPO5	-3864	1869
RPL3	-2885	2313
RPL23A	-3334	1843
NUP43	-3314	1617
RPS11	-2332	2115
RPL13A	-2727	1802
RPL32	-2103	1928
NUP210	-3943	910
NUP205	-4274	826
RPS2	-1344	2392
NUP160	-3847	763
RAN	-2142	1257
RPL35	-2671	952
RPL4	-1064	2321
RPS10	-1780	1246
RPS15	-1095	1808
RPS15A	-1762	1086
RPL17	-1654	1099
RPS3A	-1419	1275

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
CALR	2586	-3753
CANX	2151	-4839
CLTA	3788	-5077
CLTC	4149	2477
CPSF4	-3261	134
DNAJC3	3828	-2353
EIF2AK2	-3128	-3645
FAU	-124	-3862
GRSF1	1966	27
GTF2F1	1854	-1723
GTF2F2	2104	-2885
HSP90AA1	411	-781
HSPA1A	3613	-3825
IPO5	-3864	1869
ISG15	-4701	1894
KPNA1	400	-2889
KPNA2	-2190	-874
KPNA3	295	-897
KPNA4	1858	1716
KPNA5	-4625	-572
KPNB1	776	-2176
NDC1	-4789	-5228
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
PABPN1	-169	-3743
PARP1	-4548	-5521
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
POM121	-2766	-1787
POM121C	-2305	-4315
RAE1	1963	-39
RAN	-2142	1257
RANBP2	-273	-4704
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
SEC13	2266	-3749
SEH1L	-1875	-1615
TGFB1	1959	-6
TPR	-2242	-973
UBA52	349	752
XPO1	-371	-870

---

---

ER to Golgi Anterograde Transport

ER to Golgi Anterograde Transport

metric	value
setSize	105
pMANOVA	2.66e-07
p.adjustMANOVA	8.36e-06
s.dist	0.308
s.RNA	0.307
s.meth	0.0249
p.RNA	5.65e-08
p.meth	0.661

Top 20 genes

Gene	RNA	meth
KDELR1	4226	1780
TMED7	3534	1939
PPP6C	2859	2020
GOLGA2	2513	1847
COPA	3780	1056
DCTN6	3145	819
CAPZA1	3648	572
USO1	1467	1196
SAR1B	2676	489
CTSC	739	1561
COPE	2906	213
SEC24A	3350	61
TMED10	94	604

Click HERE to show all gene set members

All member genes

	RNA	meth
ACTR10	3309	-1291
ACTR1A	2965	-1
ANK1	4018	-4221
ANK3	-1491	-6563
ANKRD28	-1940	-5108
ARCN1	2180	-1676
ARF1	4184	-6686
ARF3	3396	-1912
ARF4	4256	-3280
ARF5	3493	-4789
ARFGAP1	-582	1688
ARFGAP3	1282	-5386
BET1	-192	-4482
BET1L	-2389	332
CAPZA1	3648	572
CAPZA2	3920	-36
CAPZB	3576	-4065
CD55	4229	-3923
CD59	2326	-6024
CNIH1	3425	-6699
COG1	-4760	-3663
COG2	-2597	-6132
COG3	-1652	-5701
COG4	-3	-984
COG5	-970	-1864
COG6	-1787	-358
COG7	1526	-4196
COG8	-118	1846
COPA	3780	1056
COPB1	3154	-1329
COPB2	3503	-1501
COPE	2906	213
COPZ1	1422	-5051
COPZ2	-4019	1305
CSNK1D	760	-1777
CTSC	739	1561
CTSZ	4137	-6765
DCTN2	4235	-6011
DCTN3	2396	-4272
DCTN4	3796	-2073
DCTN5	-1222	-5100
DCTN6	3145	819
DYNC1H1	-2492	1504
DYNC1I2	3399	-4337
DYNC1LI1	2930	-2912
DYNC1LI2	1527	-5470
DYNLL1	2378	-3319
DYNLL2	-1189	214
GBF1	-1279	-120
GOLGA2	2513	1847
GOLGB1	-1635	-3196
GORASP1	2742	-2178
GOSR1	-61	-3152
GOSR2	-454	1643
KDELR1	4226	1780
KDELR2	3393	-2980
LMAN1	-3888	596
LMAN2	3016	-2497
LMAN2L	2928	-1590
MCFD2	3031	-158
MIA3	-1938	-3428
NAPA	438	-4125
NAPB	-838	471
NAPG	1458	-97
PPP6C	2859	2020
PPP6R1	2015	-1276
PPP6R3	1081	-3726
RAB1A	4176	-1703
RAB1B	3749	-264
SAR1B	2676	489
SEC13	2266	-3749
SEC16A	1697	-1722
SEC22A	-1537	696
SEC22C	-1264	1879
SEC23A	3162	-5141
SEC23IP	-154	-38
SEC24A	3350	61
SEC24B	1233	-5505
SEC24C	-768	805
SEC24D	3637	-3966
SEC31A	346	-4985
SPTAN1	-4344	-1250
SPTBN1	-2529	-3924
SPTBN5	-1052	2344
STX17	-4100	-4247
STX5	3071	-1823
TBC1D20	-8	-5205
TGFA	4083	-3020
TMED10	94	604
TMED2	2424	-3656
TMED3	868	-2936
TMED7	3534	1939
TMED9	3072	-1992
TMEM115	2141	-703
TRAPPC1	3441	-3029
TRAPPC10	-3243	2388
TRAPPC2L	-686	1441
TRAPPC3	3041	-2853
TRAPPC4	-2106	-3231
TRAPPC5	1974	-5629
TRAPPC6A	-4050	1765
TRAPPC6B	1463	-662
TRAPPC9	2048	-4354
USO1	1467	1196
YKT6	1980	-3331

---

---

tRNA processing

tRNA processing

metric	value
setSize	93
pMANOVA	3e-07
p.adjustMANOVA	9.18e-06
s.dist	0.337
s.RNA	-0.319
s.meth	0.108
p.RNA	1.11e-07
p.meth	0.0718

Top 20 genes

Gene	RNA	meth
ADAT1	-3158	1883
NUP43	-3314	1617
FAM98B	-2732	1741
RPP38	-2263	1598
NUP210	-3943	910
NUP205	-4274	826
NUP160	-3847	763
RAN	-2142	1257
POP4	-1125	2076
NUP153	-1967	834
TRMT1	-1030	1178
AAAS	-2812	405
PUS7	-1663	263
CPSF4	-3261	134
NUP85	-912	317
NUP133	-2528	112
TYW5	-381	485
TRMT12	-109	956
NSUN2	-570	65

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2812	405
ADAT1	-3158	1883
ADAT2	-3526	-2393
ADAT3	347	1001
ALKBH8	-4457	-3991
C2orf49	-1785	-443
CDKAL1	-3155	-2998
CLP1	2730	-1417
CPSF1	-1130	-6284
CPSF4	-3261	134
CTU1	1699	-3154
CTU2	-3058	-2262
DDX1	-840	-558
DUS2	1175	2247
ELAC2	-4545	-916
FAM98B	-2732	1741
GTPBP3	-2334	-3838
LCMT2	-3932	-441
METTL1	-2291	-5208
MTO1	-2811	-856
NDC1	-4789	-5228
NSUN2	-570	65
NSUN6	-2512	-2844
NUP107	-3782	-1197
NUP133	-2528	112
NUP153	-1967	834
NUP155	-3676	-4352
NUP160	-3847	763
NUP188	-4466	-847
NUP205	-4274	826
NUP210	-3943	910
NUP214	3517	1119
NUP35	-3878	-321
NUP37	998	-1886
NUP43	-3314	1617
NUP50	1650	1760
NUP54	-2855	-2767
NUP62	242	-980
NUP85	-912	317
NUP88	-4326	-128
NUP93	-4463	-3462
NUP98	1012	315
POM121	-2766	-1787
POM121C	-2305	-4315
POP1	-1211	-517
POP4	-1125	2076
POP5	-3385	-4690
POP7	1464	466
PUS1	-1988	-1746
PUS3	1246	-5241
PUS7	-1663	263
QTRT1	-3345	-3239
RAE1	1963	-39
RAN	-2142	1257
RANBP2	-273	-4704
RPP14	974	-354
RPP21	-1631	-5256
RPP25	-2741	-5917
RPP30	-2675	-5522
RPP38	-2263	1598
RPP40	-1467	-1426
RPPH1	25	-5149
RTCB	-461	-261
SEC13	2266	-3749
SEH1L	-1875	-1615
THADA	-4547	-3826
THG1L	-3813	-2349
TP53RK	-4708	-2342
TPR	-2242	-973
TPRKB	-1590	-2506
TRDMT1	290	-4357
TRIT1	238	-2615
TRMT1	-1030	1178
TRMT10A	2892	-5299
TRMT11	-4226	-4066
TRMT112	233	-4666
TRMT12	-109	956
TRMT44	-2179	-1269
TRMT6	2240	1951
TRMT61A	-3328	-4239
TRMT61B	-2628	-2862
TRMU	-3201	-1879
TRNT1	-2449	-1006
TSEN15	-3498	-3075
TSEN2	-4059	-3251
TSEN34	3254	-751
TSEN54	-4841	-550
TYW1	-3175	-820
TYW3	-2782	-4913
TYW5	-381	485
URM1	-360	-3584
XPOT	-809	-828
ZBTB8OS	1520	-1338

---

---

Regulation of actin dynamics for phagocytic cup formation

Regulation of actin dynamics for phagocytic cup formation

metric	value
setSize	45
pMANOVA	5.57e-07
p.adjustMANOVA	1.66e-05
s.dist	0.462
s.RNA	0.462
s.meth	-0.012
p.RNA	8.41e-08
p.meth	0.889

Top 20 genes

Gene	RNA	meth
CYFIP1	4295	-6630
SYK	4192	-5054
NCKAP1L	3360	-6178
ACTB	4156	-4515
CRK	4091	-4581
ARPC5	3968	-3837
PAK1	3703	-3995
ARPC3	3729	-3767
ACTR2	3481	-3374
ARPC2	3191	-3647
VAV3	1824	-6342
VAV1	3499	-3184
MAPK3	4121	-2448
ACTR3	3448	-2917
WASF2	3782	-2654
GRB2	4320	-2295
CDC42	3268	-2719
ARPC1B	4291	-2022
ELMO1	2547	-2714
LIMK1	1730	-3787

Click HERE to show all gene set members

All member genes

	RNA	meth
ABI1	3018	-1788
ABI2	-4048	-5451
ABL1	63	-4891
ACTB	4156	-4515
ACTG1	3901	1793
ACTR2	3481	-3374
ACTR3	3448	-2917
ARPC1B	4291	-2022
ARPC2	3191	-3647
ARPC3	3729	-3767
ARPC5	3968	-3837
BAIAP2	-72	1977
BRK1	2983	1970
CD247	-4880	2098
CDC42	3268	-2719
CFL1	3683	912
CRK	4091	-4581
CYFIP1	4295	-6630
CYFIP2	-3754	2232
ELMO1	2547	-2714
ELMO2	1591	1326
GRB2	4320	-2295
HSP90AA1	411	-781
HSP90AB1	-2171	-5745
LIMK1	1730	-3787
MAPK1	3249	1865
MAPK3	4121	-2448
MYH9	2789	2182
MYO9B	2637	687
NCK1	-4361	-1408
NCKAP1L	3360	-6178
NCKIPSD	97	-4332
NF2	-2034	-2754
PAK1	3703	-3995
PTK2	1629	920
RAC1	4031	971
SYK	4192	-5054
VAV1	3499	-3184
VAV2	-1214	-643
VAV3	1824	-6342
WASF1	4414	-1056
WASF2	3782	-2654
WASL	87	-4742
WIPF1	177	-4382
WIPF2	2249	-2523

---

---

Response to elevated platelet cytosolic Ca2+

Response to elevated platelet cytosolic Ca2+

metric	value
setSize	53
pMANOVA	6.35e-07
p.adjustMANOVA	1.84e-05
s.dist	0.423
s.RNA	0.423
s.meth	0.00661
p.RNA	1.06e-07
p.meth	0.934

Top 20 genes

Gene	RNA	meth
ACTN1	4201	2335
WDR1	2948	2364
CALU	3497	1252
CFL1	3683	912
PFN1	2119	833
MANF	813	1947
TLN1	3876	191
PRKCA	356	810

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2170	-3533
ABCC4	3217	-3153
ACTN1	4201	2335
ACTN4	1907	-2928
ALDOA	4285	-1349
ANXA5	3692	-2845
APLP2	4343	-3465
APP	4249	-5300
BRPF3	-2062	-937
CALM1	-626	-5019
CALU	3497	1252
CAP1	3635	-553
CD63	4308	-1017
CDC37L1	-2853	1097
CFL1	3683	912
CHID1	909	-254
CYB5R1	4394	-1352
ENDOD1	1124	-4107
FAM3C	-3576	527
FERMT3	4270	-1343
GTPBP2	2582	-487
HABP4	-4052	230
MANF	813	1947
NHLRC2	-2558	-716
OLA1	1835	-508
PCYOX1L	-605	339
PFN1	2119	833
PHACTR2	2092	-6672
PLEK	633	-5891
PPIA	-2133	490
PRKCA	356	810
PRKCB	3029	-4518
PSAP	3061	-4192
QSOX1	4315	-1087
SCCPDH	3431	-5477
SOD1	-1475	-1019
SRGN	4011	-2722
STX4	189	-6001
STXBP2	4170	-6352
STXBP3	3212	-1306
TAGLN2	3178	-1136
TEX264	-2805	55
TGFB1	1959	-6
TGFB2	-2429	-6761
TGFB3	-2583	-5946
TLN1	3876	191
TMX3	-249	-6313
TOR4A	4072	-6704
TUBA4A	2678	-4571
VCL	3157	-5870
VEGFA	3235	-2723
VTI1B	4065	-359
WDR1	2948	2364

---

---

Toll-like Receptor Cascades

Toll-like Receptor Cascades

metric	value
setSize	108
pMANOVA	7.51e-07
p.adjustMANOVA	2.13e-05
s.dist	0.295
s.RNA	0.295
s.meth	0.00249
p.RNA	1.23e-07
p.meth	0.964

Top 20 genes

Gene	RNA	meth
TLR5	4260	1823
PPP2CB	3381	1797
MAPK1	3249	1865
NOD2	3833	1528
TAB2	2942	1892
ITGB2	4114	1322
CHUK	3543	1343
FOS	2120	2149
IKBKE	1750	2086
MAP3K8	2489	1442
NFKBIA	2851	1159
MAPKAPK2	1428	2012
DNM2	2448	738
PPP2CA	3707	300
UBE2N	607	1127
UBA52	349	752
JUN	1286	69

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4249	-5300
ATF1	2245	-2565
BIRC2	1737	-1862
BIRC3	-4159	-2320
BTRC	-1493	-2427
CASP8	-4285	387
CHUK	3543	1343
CNPY3	3416	-3161
CREB1	-430	-672
CTSB	4350	-4209
CTSL	1504	-6671
CTSS	3785	-2958
CTSV	-910	-5834
CUL1	-4281	-5146
DNM1	1225	-5619
DNM2	2448	738
DUSP3	4305	-1798
DUSP4	-1957	-3176
DUSP6	1570	-6763
DUSP7	-960	-1322
ECSIT	1839	-4938
EEA1	1708	-711
FADD	2211	-6328
FBXW11	2510	-6747
FOS	2120	2149
GSDMD	614	-3378
HMGB1	-86	-1263
HSP90B1	647	-1371
IKBKB	-1640	-3894
IKBKE	1750	2086
IRAK2	-3327	-1457
IRAK3	4208	-6295
IRF3	-2870	542
IRF7	-2922	1622
ITGB2	4114	1322
JUN	1286	69
LGMN	-1401	313
MAP2K1	4183	-698
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAP3K1	1942	-176
MAP3K7	761	-2089
MAP3K8	2489	1442
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPK8	-3265	6
MAPK9	-2259	872
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MEF2A	3571	-2822
MYD88	3649	-1927
NFKB2	-367	388
NFKBIA	2851	1159
NFKBIB	-48	-3368
NKIRAS1	116	-3490
NKIRAS2	4346	-5039
NOD1	-4837	-5170
NOD2	3833	1528
PELI1	2800	-3839
PELI2	3750	-2561
PELI3	3383	-4323
PIK3R4	-1215	-3425
PLCG2	1884	-2562
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5D	771	-4349
PTPN11	2038	-2302
PTPN4	-4818	-3156
RBSN	-1363	-2813
RELA	-542	2085
RIPK3	1497	-370
RPS27A	-2201	-2138
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA5	-4445	-514
SARM1	-4766	-5412
SIGIRR	-3958	290
SKP1	1536	-2290
SOCS1	1375	-2999
TAB2	2942	1892
TANK	3251	-1331
TBK1	1067	-4616
TICAM1	2569	-2136
TIRAP	2210	-5182
TLR1	4106	-6127
TLR2	4206	-6586
TLR3	-4406	-5820
TLR5	4260	1823
TLR6	4058	-802
TLR9	-1850	2292
TNIP2	2166	-5726
TRAF3	-1701	2379
TRAF6	-80	-6118
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2D1	4255	-1581
UBE2D2	1717	-3799
UBE2D3	3944	-373
UBE2N	607	1127
UBE2V1	2209	-1021
UNC93B1	1479	-4358
VRK3	396	-1398

---

---

Leishmania infection

Leishmania infection

metric	value
setSize	110
pMANOVA	9.26e-07
p.adjustMANOVA	2.56e-05
s.dist	0.295
s.RNA	0.29
s.meth	-0.054
p.RNA	1.58e-07
p.meth	0.33

Top 20 genes

Gene	RNA	meth
GGT1	4376	-6607
HRH2	4395	-6490
CYFIP1	4295	-6630
ADM	4359	-6151
PRKACA	4378	-6032
PYCARD	3942	-6598
NLRP3	4089	-6357
C3AR1	3573	-6729
SYK	4192	-5054
NCKAP1L	3360	-6178
FGR	3853	-5292
GNB4	3163	-6007
ACTB	4156	-4515
CRK	4091	-4581
ARPC5	3968	-3837
MAPK14	4207	-3529
ITPR2	2315	-6107
ARPC3	3729	-3767
ADCY4	2020	-6389
ACTR2	3481	-3374

Click HERE to show all gene set members

All member genes

	RNA	meth
ABI1	3018	-1788
ABI2	-4048	-5451
ABL1	63	-4891
ACTB	4156	-4515
ACTG1	3901	1793
ACTR2	3481	-3374
ACTR3	3448	-2917
ADAM17	3634	774
ADCY4	2020	-6389
ADCY7	-980	-5596
ADCY9	33	-2618
ADM	4359	-6151
ADORA2A	1094	-5935
ADRB2	-4624	-3531
AHCYL1	2658	-3553
ARPC1B	4291	-2022
ARPC2	3191	-3647
ARPC3	3729	-3767
ARPC5	3968	-3837
BAIAP2	-72	1977
BRK1	2983	1970
C3AR1	3573	-6729
CALM1	-626	-5019
CASP1	1501	-1448
CD247	-4880	2098
CDC42	3268	-2719
CREB1	-430	-672
CRK	4091	-4581
CYBA	2922	1006
CYFIP1	4295	-6630
CYFIP2	-3754	2232
DPEP2	-808	-6530
DVL1	0	-4520
DVL2	-4172	-1356
DVL3	2219	-3704
ELMO1	2547	-2714
ELMO2	1591	1326
ENTPD1	3775	2446
ENTPD5	-1913	-4305
FGR	3853	-5292
FURIN	4191	2351
FYN	-4495	1957
FZD7	-2024	-3834
GGT1	4376	-6607
GIPR	-4745	-2380
GNAI2	3616	-1747
GNAI3	3536	-909
GNAS	3508	951
GNB1	3736	-2920
GNB2	3650	-309
GNB4	3163	-6007
GNB5	163	1821
GNG2	-2538	-3847
GNG3	285	2231
GNG4	-649	2073
GNG5	4043	1920
GNG7	-1581	-4773
GNGT2	-4735	2438
GRB2	4320	-2295
GSDMD	614	-3378
HRH2	4395	-6490
HSP90AB1	-2171	-5745
ITPR1	-2478	-3278
ITPR2	2315	-6107
ITPR3	-3717	-3427
JUN	1286	69
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK8	-3265	6
MYH9	2789	2182
MYO9B	2637	687
NCK1	-4361	-1408
NCKAP1L	3360	-6178
NCKIPSD	97	-4332
NFKB2	-367	388
NLRP3	4089	-6357
NOXA1	-1664	-5872
P2RX4	3328	174
PLCG1	-4158	-3541
PLCG2	1884	-2562
PLK2	-827	-6257
PRKACA	4378	-6032
PRKACB	-4656	455
PRKAR1A	3924	-201
PRKAR1B	3514	731
PRKAR2A	2493	-4298
PSTPIP1	3462	1135
PTGER2	448	-5853
PTGER4	-4508	1153
PTK2	1629	920
PYCARD	3942	-6598
RAC1	4031	971
RELA	-542	2085
RHBDF2	1487	-4959
SRC	-2999	-4427
SUGT1	475	594
SYK	4192	-5054
TXN	3732	284
TXNIP	-3347	-2777
VAV1	3499	-3184
VAV2	-1214	-643
VAV3	1824	-6342
VIPR1	-1904	-3480
WASF1	4414	-1056
WASF2	3782	-2654
WASL	87	-4742
WIPF1	177	-4382
WIPF2	2249	-2523
YES1	-4772	-4415

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	67
pMANOVA	9.52e-07
p.adjustMANOVA	2.57e-05
s.dist	0.387
s.RNA	-0.245
s.meth	0.3
p.RNA	0.000531
p.meth	2.26e-05

Top 20 genes

Gene	RNA	meth
RPL3	-2885	2313
RPL23A	-3334	1843
RPS11	-2332	2115
RPL13A	-2727	1802
RPL32	-2103	1928
RPS2	-1344	2392
RPL35	-2671	952
RPL4	-1064	2321
RPS10	-1780	1246
RPS15	-1095	1808
RPS15A	-1762	1086
RPL17	-1654	1099
RPS3A	-1419	1275
RPS16	-1410	1043
RPLP2	-2265	579
RPS8	-627	1886
EEF1A1	-1549	720
RPS28	-1426	525
RPS25	-1980	254
RPL6	-999	474

Click HERE to show all gene set members

All member genes

	RNA	meth
EEF1A1	-1549	720
EEF2	90	2127
FAU	-124	-3862
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
UBA52	349	752

---

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	70
pMANOVA	1.15e-06
p.adjustMANOVA	3.02e-05
s.dist	0.377
s.RNA	-0.239
s.meth	0.291
p.RNA	0.00057
p.meth	2.6e-05

Top 20 genes

Gene	RNA	meth
RPL3	-2885	2313
RPL23A	-3334	1843
RPS11	-2332	2115
RPL13A	-2727	1802
RPL32	-2103	1928
RPS2	-1344	2392
RPL35	-2671	952
RPL4	-1064	2321
RPS10	-1780	1246
EEF1B2	-1271	1717
RPS15	-1095	1808
RPS15A	-1762	1086
RPL17	-1654	1099
RPS3A	-1419	1275
RPS16	-1410	1043
RPLP2	-2265	579
RPS8	-627	1886
EEF1A1	-1549	720
RPS28	-1426	525
RPS25	-1980	254

Click HERE to show all gene set members

All member genes

	RNA	meth
EEF1A1	-1549	720
EEF1B2	-1271	1717
EEF1D	-268	-885
EEF1G	-431	-5880
EEF2	90	2127
FAU	-124	-3862
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
UBA52	349	752

---

---

Apoptosis

Apoptosis

metric	value
setSize	132
pMANOVA	1.27e-06
p.adjustMANOVA	3.04e-05
s.dist	0.259
s.RNA	0.255
s.meth	0.046
p.RNA	4.7e-07
p.meth	0.364

Top 20 genes

Gene	RNA	meth
MAPK1	3249	1865
BCL2L11	3187	1781
YWHAB	2611	2125
TNFRSF10B	3754	1433
PSMA7	3028	1752
BCL2L1	3979	1306
PSMD1	3112	1660
PSME3	3715	1116
PSMD12	2710	1314
PSMB2	1439	2355
PSMD13	2376	1328
PSMA2	2052	1205
PRKCD	4154	584
BID	2410	844
PTK2	1629	920
CARD8	1753	794
YWHAZ	2200	541
PLEC	1704	385
CFLAR	3312	197
UBA52	349	752

Click HERE to show all gene set members

All member genes

	RNA	meth
ACIN1	275	-1699
ADD1	2243	-89
AKT1	1234	-1942
AKT2	133	-141
APAF1	4158	-2104
APC	1073	-4775
APPL1	101	28
ARHGAP10	-3012	2322
AVEN	-2690	1579
BAD	2904	-1382
BAK1	-105	-4022
BAX	2357	-3623
BBC3	-2571	-3845
BCL2	-1421	2361
BCL2L1	3979	1306
BCL2L11	3187	1781
BID	2410	844
BIRC2	1737	-1862
BMF	1582	-6386
C1QBP	-275	-2507
CARD8	1753	794
CASP3	-208	-2764
CASP6	-856	-4898
CASP7	13	-842
CASP8	-4285	387
CASP9	3366	-234
CDKN2A	-1595	-4511
CFLAR	3312	197
CLSPN	1244	-1524
CTNNB1	2626	-1691
CYCS	-411	-3927
DAPK2	3108	-2374
DAPK3	1648	-4978
DBNL	3411	-3713
DFFA	1130	-3179
DFFB	-2160	-4631
DIABLO	-1989	-5548
DNM1L	978	-5217
DYNLL1	2378	-3319
DYNLL2	-1189	214
E2F1	2589	-1005
FADD	2211	-6328
FAS	1281	-5824
FNTA	-1755	1499
GSDMD	614	-3378
HMGB1	-86	-1263
HMGB2	3960	-5133
KPNA1	400	-2889
KPNB1	776	-2176
LMNA	1348	-6474
LMNB1	4342	-942
MAPK1	3249	1865
MAPK3	4121	-2448
MAPK8	-3265	6
MAPT	-1656	2342
NMT1	1558	-3001
OMA1	949	-5732
OPA1	876	-4730
PAK2	3682	-3961
PLEC	1704	385
PMAIP1	-4091	-2202
PPP1R13B	-4473	1874
PPP3CC	-4761	1250
PPP3R1	3675	-3276
PRKCD	4154	584
PRKCQ	-4762	1372
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTK2	1629	920
ROCK1	3246	-985
RPS27A	-2201	-2138
SATB1	-2592	-1979
SFN	500	-5994
SPTAN1	-4344	-1250
STAT3	3628	-3606
STK24	2680	-1640
TFDP1	3849	-1587
TFDP2	-4891	-4793
TICAM1	2569	-2136
TJP2	1460	-67
TNFRSF10A	561	-3935
TNFRSF10B	3754	1433
TNFSF10	1009	-2143
TP53	-4034	-739
TP53BP2	2152	-5830
TRADD	-179	-1481
TRAF2	-4539	-1442
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
VIM	4364	-2247
YWHAB	2611	2125
YWHAE	4173	-4168
YWHAG	4294	-5545
YWHAH	3949	-2902
YWHAQ	-2362	-2908
YWHAZ	2200	541

---

---

Developmental Biology

Developmental Biology

metric	value
setSize	450
pMANOVA	1.3e-06
p.adjustMANOVA	3.04e-05
s.dist	0.145
s.RNA	0.145
s.meth	-0.00542
p.RNA	1.98e-07
p.meth	0.846

Top 20 genes

Gene	RNA	meth
SEMA4A	4181	-6718
SPI1	4085	-6766
FES	4278	-6334
ACVR1B	4222	-6300
PRKACA	4378	-6032
CEBPA	3737	-6768
CAPN1	3902	-6119
IL6R	3645	-6410
ITGA5	3349	-6767
RPS6KA1	3372	-6629
GAB2	3629	-6153
LIMK2	3615	-6093
TYROBP	3270	-6720
MPZ	3454	-6222
CEBPE	3183	-6744
IRS2	3903	-5410
PLXND1	3238	-6504
NR6A1	3895	-5344
PDLIM7	4095	-5081
CEBPD	4044	-5142

Click HERE to show all gene set members

All member genes

	RNA	meth
ABL1	63	-4891
ABL2	1565	301
ABLIM1	-3786	-4330
ABLIM2	-3479	-5662
ACTB	4156	-4515
ACTG1	3901	1793
ACTR2	3481	-3374
ACTR3	3448	-2917
ACVR1B	4222	-6300
ACVR2A	-4287	-4829
ADAM10	4030	976
ADAM11	-3126	-2252
ADAM22	-4191	-2633
AGAP2	-1777	-3508
AGRN	-4553	-2304
AJUBA	-2602	-2301
AKT1	1234	-1942
AKT2	133	-141
ALCAM	4273	-1377
ANK1	4018	-4221
ANK3	-1491	-6563
AP2A1	2869	-4887
AP2M1	3936	20
AP2S1	3581	-3262
APH1A	1453	-6066
APH1B	2555	2056
ARHGAP35	-1001	-3660
ARHGAP39	-2705	-5852
ARHGEF12	1041	-4362
ARHGEF7	-1379	-5507
ARPC1B	4291	-2022
ARPC2	3191	-3647
ARPC3	3729	-3767
ARPC5	3968	-3837
ASH2L	2400	-3791
BNIP2	3932	-1121
CACNA1C	-4026	-4608
CACNA1I	-1289	-5788
CACNB3	111	-6297
CAP1	3635	-553
CAPN1	3902	-6119
CAPNS1	3394	-2032
CASC3	2005	-2580
CBFB	656	-3766
CCNC	589	-1138
CCND3	3245	905
CD72	-1501	-4837
CDC42	3268	-2719
CDK19	3319	-2575
CDK2	-1522	1018
CDK4	-4235	-1295
CDK5	3929	-506
CDK5R1	-346	-2113
CDK8	-594	-5509
CDKN1A	1646	-3540
CDON	-2710	-2931
CEBPA	3737	-6768
CEBPB	3564	-5089
CEBPD	4044	-5142
CEBPE	3183	-6744
CFL1	3683	912
CHD9	-1380	-5791
CLASP1	-191	-390
CLASP2	-647	-4366
CLTA	3788	-5077
CLTB	2446	-3627
CLTC	4149	2477
CLTCL1	4130	-4995
CNOT6	1783	-3728
CNTNAP1	-1556	-313
COL9A2	-3430	-2895
CREB1	-430	-672
CREBBP	1153	-5804
CSNK2A2	2614	-4422
CSNK2B	1389	-998
CTCF	-3196	764
CTNNB1	2626	-1691
CUL2	805	-1212
CXCR4	-19	-1660
CYP51A1	2876	-5191
DAG1	-2376	-146
DEK	853	1060
DLG1	-2787	-3985
DLG4	4153	-3021
DNM1	1225	-5619
DNM2	2448	738
DOK2	-311	-2493
DOK4	904	-661
DPYSL2	3654	-108
DRAP1	-2249	-2142
E2F1	2589	-1005
EED	-3235	-1174
EFNA3	-2639	568
EFNA4	2473	-3312
EFNB2	-1915	-5564
EGR2	-450	-2628
EIF4A3	3132	-3850
EIF4G1	3585	746
EP300	2471	-4509
EPAS1	3494	535
EPHA4	-4347	630
EPHB6	50	-5408
ERBB2	-4865	-5145
ETF1	3209	758
EVL	-4808	2303
EZH2	-3415	-20
EZR	-4552	1610
FAM120B	-4	-2607
FARP2	-3348	1936
FAU	-124	-3862
FES	4278	-6334
FGF9	-2970	1634
FLI1	2169	-573
FOXO1	-3290	-5036
FOXO3	3966	711
FOXP1	-2900	881
FRS2	-1025	-1999
FURIN	4191	2351
FYN	-4495	1957
GAB2	3629	-6153
GFI1	-4663	-2672
GIT1	-3293	-6740
GRB10	4386	-70
GRB2	4320	-2295
GSK3B	2756	736
GSPT1	2672	-4456
HDAC2	2129	-46
HDAC3	1727	-3771
HHEX	3139	-6522
HMGCR	3626	-3388
HOXA1	-3187	-1478
HRAS	-1008	-4780
HSP90AA1	411	-781
HSP90AB1	-2171	-5745
IL6R	3645	-6410
IRS2	3903	-5410
ITGA1	3994	-4187
ITGA2	1478	-3856
ITGA5	3349	-6767
ITGAV	2457	-5201
ITSN1	4309	-1048
JUN	1286	69
KAT2A	-3970	-5050
KAT2B	-722	-1588
KLF5	1908	-6396
KMT2A	-3942	2484
KMT2C	17	-6379
KMT2D	1057	-6199
KRAS	1276	440
KRT10	327	-286
LAMA2	-3504	-1315
LDB1	-3712	1270
LIMK1	1730	-3787
LIMK2	3615	-6093
LYPLA2	2878	-782
MAML1	2088	-5348
MAML2	-189	-2078
MAML3	4123	-4054
MAP2K1	4183	-698
MAP2K2	2840	-3962
MAP2K6	4082	-1130
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPK8	-3265	6
MBP	-1803	-4838
MED1	-1206	-2271
MED10	-2893	-2572
MED11	-181	609
MED13	807	590
MED13L	2440	-533
MED15	-3434	2114
MED16	2024	1719
MED17	1004	-1418
MED18	1590	-186
MED19	1074	-4664
MED20	2814	-542
MED21	-1826	-582
MED22	1321	-2059
MED23	-2139	633
MED24	-2380	-2701
MED25	2518	-1286
MED26	1589	18
MED27	-3167	-960
MED28	-445	699
MED29	-2631	-5128
MED30	-1669	491
MED31	447	445
MED4	1062	-4472
MED6	-279	560
MED7	62	778
MED8	3267	1289
MED9	-2996	-3399
MEF2A	3571	-2822
MEF2D	-929	-3018
MPZ	3454	-6222
MYB	88	1502
MYH10	206	-4405
MYH9	2789	2182
MYL12A	2908	-2655
MYL6	3908	-19
MYO9B	2637	687
NAB1	416	-2731
NAB2	-3772	989
NCBP1	-1807	-3745
NCBP2	-3329	-4067
NCK1	-4361	-1408
NCK2	1848	-4310
NCOA2	343	1407
NCOA3	1198	-2266
NCOA6	2280	-1860
NCOR1	2341	-3738
NCOR2	3557	-4281
NCSTN	4254	-3821
NEO1	-3435	-4340
NOTCH1	1743	1722
NR6A1	3895	-5344
NTN1	-1405	-2727
NUMB	4372	-35
ONECUT1	799	-6035
PABPC1	2061	-2769
PAGR1	2023	2336
PAK1	3703	-3995
PAK2	3682	-3961
PAK4	-464	-1464
PAXIP1	-3077	-3883
PDLIM7	4095	-5081
PFN1	2119	833
PFN2	-697	-6463
PIAS2	-2430	-2314
PIK3CA	1703	-1445
PIK3CD	2422	2189
PIK3R1	-3307	2310
PIK3R2	1887	-1223
PIK3R3	-4692	-22
PIP5K1C	1151	-5383
PITPNA	2860	-2752
PKNOX1	-798	1315
PKP4	988	-5121
PLCG1	-4158	-3541
PLXNA2	2949	634
PLXNC1	4238	-3505
PLXND1	3238	-6504
PML	-2938	549
POLR2A	-928	-3832
POLR2B	-751	926
POLR2C	501	1027
POLR2D	-1201	-2419
POLR2E	3283	-1584
POLR2F	1692	-4483
POLR2G	1190	-2402
POLR2H	-882	1944
POLR2I	123	-5210
POLR2K	-537	-2424
PPP3CB	2968	517
PRKACA	4378	-6032
PRKACB	-4656	455
PRKAR2A	2493	-4298
PRKCA	356	810
PRKCQ	-4762	1372
PRNP	1517	-4177
PSEN1	3540	-3407
PSEN2	-2508	-5155
PSENEN	2260	-3620
PSMA1	3158	-1782
PSMA2	2052	1205
PSMA3	-1612	-2824
PSMA5	-1869	592
PSMA6	2386	-1838
PSMA7	3028	1752
PSMB1	1131	-1179
PSMB10	-1758	-4718
PSMB2	1439	2355
PSMB3	3076	-2678
PSMB5	3630	-4604
PSMB6	2854	-3576
PSMB7	3856	-2038
PSMB8	-921	1189
PSMB9	-4276	-1453
PSMC1	2977	-5705
PSMC3	624	-4615
PSMC4	-3133	1003
PSMC5	-287	-3263
PSMC6	2757	-5508
PSMD1	3112	1660
PSMD11	2532	-2152
PSMD12	2710	1314
PSMD13	2376	1328
PSMD14	836	-2484
PSMD2	3204	-85
PSMD3	1696	-4331
PSMD4	3806	-4683
PSMD6	3465	-5488
PSMD7	2383	7
PSMD8	2270	-3290
PSMD9	3321	-2041
PSME1	-3548	-2343
PSME2	-3731	-2364
PSME3	3715	1116
PSME4	-1884	-3380
PSMF1	2775	-4867
PTK2	1629	920
PTPN11	2038	-2302
PTPRA	-1393	1436
PTPRC	706	-1407
RAC1	4031	971
RANBP9	2299	-1361
RARA	2642	-5249
RARG	-1567	-5402
RASA1	664	-167
RBBP4	-565	-3282
RBBP5	328	-779
RBPJ	4017	-1118
RBX1	1368	-3241
RELA	-542	2085
RHOA	3753	1313
RHOB	390	-4992
RND1	-481	-2463
RNPS1	-4345	-3160
ROCK1	3246	-985
RPL10A	-2096	-648
RPL11	-1944	-2771
RPL13	-1024	-191
RPL13A	-2727	1802
RPL14	-2104	-100
RPL15	-313	-4694
RPL17	-1654	1099
RPL18	-1546	-2031
RPL18A	-1876	-4966
RPL22	-1434	-3996
RPL23	-990	-566
RPL23A	-3334	1843
RPL26	-2060	-1489
RPL26L1	3079	-2860
RPL27A	-1942	-55
RPL28	-456	-3478
RPL29	-1075	305
RPL3	-2885	2313
RPL31	-1362	-2278
RPL32	-2103	1928
RPL34	-2147	-3159
RPL35	-2671	952
RPL36	-1614	4
RPL36AL	9	1901
RPL37	-1982	-126
RPL37A	-1178	211
RPL38	-1800	-818
RPL39L	-2993	-329
RPL4	-1064	2321
RPL41	-2172	-229
RPL6	-999	474
RPL7	-589	-6019
RPL8	-373	-5267
RPL9	-566	741
RPLP0	-320	-185
RPLP1	3	-4053
RPLP2	-2265	579
RPS10	-1780	1246
RPS11	-2332	2115
RPS12	-1841	-379
RPS15	-1095	1808
RPS15A	-1762	1086
RPS16	-1410	1043
RPS18	-2520	-3281
RPS19	-2212	-4563
RPS2	-1344	2392
RPS20	-3028	-1962
RPS23	-1958	-1981
RPS24	-87	-2012
RPS25	-1980	254
RPS26	-446	-3094
RPS27A	-2201	-2138
RPS27L	649	-2218
RPS28	-1426	525
RPS29	-2606	-159
RPS3	-1822	-632
RPS3A	-1419	1275
RPS5	-1744	-1026
RPS6	-1906	-1785
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA4	626	-6624
RPS6KA5	-4445	-514
RPS7	-1509	-2594
RPS8	-627	1886
RPS9	2097	139
RPSA	-1968	-1486
RRAS	1219	420
RUNX1	3262	-4082
SDCBP	4324	-2535
SEMA3A	-1808	-6089
SEMA4A	4181	-6718
SEMA4D	-855	2276
SEMA7A	-3074	-4299
SHC1	1472	-2954
SIAH1	-897	-6217
SIAH2	3910	2185
SLIT1	1778	-6622
SMAD2	1830	-1994
SMAD3	-4538	-4628
SMAD4	-2796	-6535
SMARCA4	1758	2317
SNW1	1979	946
SOS1	-1748	-6775
SOS2	3740	-4105
SPAG9	1784	-4933
SPI1	4085	-6766
SPTAN1	-4344	-1250
SPTBN1	-2529	-3924
SPTBN5	-1052	2344
SRC	-2999	-4427
SREBF1	2701	-4015
SREBF2	2792	-1852
SRGAP1	2815	-6096
SRGAP3	-1738	-4649
ST8SIA4	3708	-3013
STAT3	3628	-3606
STX1A	-1213	-2461
STX1B	-886	-6167
TBL1XR1	1669	962
TCF12	-386	-4702
TCF3	-2318	-6049
TFDP1	3849	-1587
TFDP2	-4891	-4793
TGFB1	1959	-6
TLN1	3876	191
TNF	-2348	-3779
TRIO	562	-5812
TRPC1	-3412	-2704
TSC22D1	1660	-5391
TYROBP	3270	-6720
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UPF2	307	-1572
UPF3A	-3462	2175
USP33	-274	-5582
UTRN	-4626	1312
VASP	3582	-2892
VAV2	-1214	-643
VAV3	1824	-6342
WASL	87	-4742
WDR5	39	-5613
WNT1	-3087	-5360
YES1	-4772	-4415
YY1	169	-5165
ZNF335	-2546	-44
ZNF638	1340	1335
ZSWIM8	2045	-5960

---

---

Toll Like Receptor 4 (TLR4) Cascade

Toll Like Receptor 4 (TLR4) Cascade

metric	value
setSize	93
pMANOVA	1.31e-06
p.adjustMANOVA	3.04e-05
s.dist	0.31
s.RNA	0.309
s.meth	0.0224
p.RNA	2.72e-07
p.meth	0.709

Top 20 genes

Gene	RNA	meth
PPP2CB	3381	1797
MAPK1	3249	1865
NOD2	3833	1528
TAB2	2942	1892
ITGB2	4114	1322
CHUK	3543	1343
FOS	2120	2149
IKBKE	1750	2086
MAP3K8	2489	1442
NFKBIA	2851	1159
MAPKAPK2	1428	2012
DNM2	2448	738
PPP2CA	3707	300
UBE2N	607	1127
UBA52	349	752
JUN	1286	69

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4249	-5300
ATF1	2245	-2565
BIRC2	1737	-1862
BIRC3	-4159	-2320
BTRC	-1493	-2427
CASP8	-4285	387
CHUK	3543	1343
CREB1	-430	-672
CUL1	-4281	-5146
DNM1	1225	-5619
DNM2	2448	738
DUSP3	4305	-1798
DUSP4	-1957	-3176
DUSP6	1570	-6763
DUSP7	-960	-1322
ECSIT	1839	-4938
FADD	2211	-6328
FBXW11	2510	-6747
FOS	2120	2149
HMGB1	-86	-1263
IKBKB	-1640	-3894
IKBKE	1750	2086
IRAK2	-3327	-1457
IRAK3	4208	-6295
IRF3	-2870	542
IRF7	-2922	1622
ITGB2	4114	1322
JUN	1286	69
MAP2K1	4183	-698
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAP3K1	1942	-176
MAP3K7	761	-2089
MAP3K8	2489	1442
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPK8	-3265	6
MAPK9	-2259	872
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MEF2A	3571	-2822
MYD88	3649	-1927
NFKB2	-367	388
NFKBIA	2851	1159
NFKBIB	-48	-3368
NKIRAS1	116	-3490
NKIRAS2	4346	-5039
NOD1	-4837	-5170
NOD2	3833	1528
PELI1	2800	-3839
PELI2	3750	-2561
PELI3	3383	-4323
PLCG2	1884	-2562
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5D	771	-4349
PTPN11	2038	-2302
PTPN4	-4818	-3156
RELA	-542	2085
RIPK3	1497	-370
RPS27A	-2201	-2138
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA5	-4445	-514
SARM1	-4766	-5412
SIGIRR	-3958	290
SKP1	1536	-2290
SOCS1	1375	-2999
TAB2	2942	1892
TANK	3251	-1331
TBK1	1067	-4616
TICAM1	2569	-2136
TIRAP	2210	-5182
TLR1	4106	-6127
TLR2	4206	-6586
TLR6	4058	-802
TNIP2	2166	-5726
TRAF3	-1701	2379
TRAF6	-80	-6118
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2D1	4255	-1581
UBE2D2	1717	-3799
UBE2D3	3944	-373
UBE2N	607	1127
UBE2V1	2209	-1021
VRK3	396	-1398

---

---

MyD88:MAL(TIRAP) cascade initiated on plasma membrane

MyD88:MAL(TIRAP) cascade initiated on plasma membrane

metric	value
setSize	71
pMANOVA	1.34e-06
p.adjustMANOVA	3.04e-05
s.dist	0.357
s.RNA	0.357
s.meth	-0.00759
p.RNA	2.09e-07
p.meth	0.912

Top 20 genes

Gene	RNA	meth
TLR2	4206	-6586
IRAK3	4208	-6295
TLR1	4106	-6127
APP	4249	-5300
RPS6KA1	3372	-6629
NKIRAS2	4346	-5039
MAPKAPK3	3794	-4540
FBXW11	2510	-6747
MAP2K4	2891	-5363
MAPK14	4207	-3529
PELI3	3383	-4323
TNIP2	2166	-5726
TIRAP	2210	-5182
PELI1	2800	-3839
MAP2K3	4006	-2657
DUSP6	1570	-6763
MAPK3	4121	-2448
MEF2A	3571	-2822
PELI2	3750	-2561
ECSIT	1839	-4938

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4249	-5300
ATF1	2245	-2565
BTRC	-1493	-2427
CHUK	3543	1343
CREB1	-430	-672
CUL1	-4281	-5146
DUSP3	4305	-1798
DUSP4	-1957	-3176
DUSP6	1570	-6763
DUSP7	-960	-1322
ECSIT	1839	-4938
FBXW11	2510	-6747
FOS	2120	2149
HMGB1	-86	-1263
IKBKB	-1640	-3894
IRAK2	-3327	-1457
IRAK3	4208	-6295
JUN	1286	69
MAP2K1	4183	-698
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAP3K1	1942	-176
MAP3K7	761	-2089
MAP3K8	2489	1442
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPK8	-3265	6
MAPK9	-2259	872
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MEF2A	3571	-2822
MYD88	3649	-1927
NFKB2	-367	388
NFKBIA	2851	1159
NFKBIB	-48	-3368
NKIRAS1	116	-3490
NKIRAS2	4346	-5039
NOD1	-4837	-5170
NOD2	3833	1528
PELI1	2800	-3839
PELI2	3750	-2561
PELI3	3383	-4323
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5D	771	-4349
RELA	-542	2085
RPS27A	-2201	-2138
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA5	-4445	-514
SIGIRR	-3958	290
SKP1	1536	-2290
SOCS1	1375	-2999
TAB2	2942	1892
TIRAP	2210	-5182
TLR1	4106	-6127
TLR2	4206	-6586
TLR6	4058	-802
TNIP2	2166	-5726
TRAF6	-80	-6118
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2N	607	1127
UBE2V1	2209	-1021
VRK3	396	-1398

---

---

Toll Like Receptor 2 (TLR2) Cascade

Toll Like Receptor 2 (TLR2) Cascade

metric	value
setSize	71
pMANOVA	1.34e-06
p.adjustMANOVA	3.04e-05
s.dist	0.357
s.RNA	0.357
s.meth	-0.00759
p.RNA	2.09e-07
p.meth	0.912

Top 20 genes

Gene	RNA	meth
TLR2	4206	-6586
IRAK3	4208	-6295
TLR1	4106	-6127
APP	4249	-5300
RPS6KA1	3372	-6629
NKIRAS2	4346	-5039
MAPKAPK3	3794	-4540
FBXW11	2510	-6747
MAP2K4	2891	-5363
MAPK14	4207	-3529
PELI3	3383	-4323
TNIP2	2166	-5726
TIRAP	2210	-5182
PELI1	2800	-3839
MAP2K3	4006	-2657
DUSP6	1570	-6763
MAPK3	4121	-2448
MEF2A	3571	-2822
PELI2	3750	-2561
ECSIT	1839	-4938

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4249	-5300
ATF1	2245	-2565
BTRC	-1493	-2427
CHUK	3543	1343
CREB1	-430	-672
CUL1	-4281	-5146
DUSP3	4305	-1798
DUSP4	-1957	-3176
DUSP6	1570	-6763
DUSP7	-960	-1322
ECSIT	1839	-4938
FBXW11	2510	-6747
FOS	2120	2149
HMGB1	-86	-1263
IKBKB	-1640	-3894
IRAK2	-3327	-1457
IRAK3	4208	-6295
JUN	1286	69
MAP2K1	4183	-698
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAP3K1	1942	-176
MAP3K7	761	-2089
MAP3K8	2489	1442
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPK8	-3265	6
MAPK9	-2259	872
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MEF2A	3571	-2822
MYD88	3649	-1927
NFKB2	-367	388
NFKBIA	2851	1159
NFKBIB	-48	-3368
NKIRAS1	116	-3490
NKIRAS2	4346	-5039
NOD1	-4837	-5170
NOD2	3833	1528
PELI1	2800	-3839
PELI2	3750	-2561
PELI3	3383	-4323
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5D	771	-4349
RELA	-542	2085
RPS27A	-2201	-2138
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA5	-4445	-514
SIGIRR	-3958	290
SKP1	1536	-2290
SOCS1	1375	-2999
TAB2	2942	1892
TIRAP	2210	-5182
TLR1	4106	-6127
TLR2	4206	-6586
TLR6	4058	-802
TNIP2	2166	-5726
TRAF6	-80	-6118
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2N	607	1127
UBE2V1	2209	-1021
VRK3	396	-1398

---

---

Toll Like Receptor TLR1:TLR2 Cascade

Toll Like Receptor TLR1:TLR2 Cascade

metric	value
setSize	71
pMANOVA	1.34e-06
p.adjustMANOVA	3.04e-05
s.dist	0.357
s.RNA	0.357
s.meth	-0.00759
p.RNA	2.09e-07
p.meth	0.912

Top 20 genes

Gene	RNA	meth
TLR2	4206	-6586
IRAK3	4208	-6295
TLR1	4106	-6127
APP	4249	-5300
RPS6KA1	3372	-6629
NKIRAS2	4346	-5039
MAPKAPK3	3794	-4540
FBXW11	2510	-6747
MAP2K4	2891	-5363
MAPK14	4207	-3529
PELI3	3383	-4323
TNIP2	2166	-5726
TIRAP	2210	-5182
PELI1	2800	-3839
MAP2K3	4006	-2657
DUSP6	1570	-6763
MAPK3	4121	-2448
MEF2A	3571	-2822
PELI2	3750	-2561
ECSIT	1839	-4938

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4249	-5300
ATF1	2245	-2565
BTRC	-1493	-2427
CHUK	3543	1343
CREB1	-430	-672
CUL1	-4281	-5146
DUSP3	4305	-1798
DUSP4	-1957	-3176
DUSP6	1570	-6763
DUSP7	-960	-1322
ECSIT	1839	-4938
FBXW11	2510	-6747
FOS	2120	2149
HMGB1	-86	-1263
IKBKB	-1640	-3894
IRAK2	-3327	-1457
IRAK3	4208	-6295
JUN	1286	69
MAP2K1	4183	-698
MAP2K3	4006	-2657
MAP2K4	2891	-5363
MAP2K6	4082	-1130
MAP2K7	514	-3915
MAP3K1	1942	-176
MAP3K7	761	-2089
MAP3K8	2489	1442
MAPK1	3249	1865
MAPK14	4207	-3529
MAPK3	4121	-2448
MAPK7	-412	-1630
MAPK8	-3265	6
MAPK9	-2259	872
MAPKAPK2	1428	2012
MAPKAPK3	3794	-4540
MEF2A	3571	-2822
MYD88	3649	-1927
NFKB2	-367	388
NFKBIA	2851	1159
NFKBIB	-48	-3368
NKIRAS1	116	-3490
NKIRAS2	4346	-5039
NOD1	-4837	-5170
NOD2	3833	1528
PELI1	2800	-3839
PELI2	3750	-2561
PELI3	3383	-4323
PPP2CA	3707	300
PPP2CB	3381	1797
PPP2R1B	-84	-2554
PPP2R5D	771	-4349
RELA	-542	2085
RPS27A	-2201	-2138
RPS6KA1	3372	-6629
RPS6KA2	1006	-1784
RPS6KA5	-4445	-514
SIGIRR	-3958	290
SKP1	1536	-2290
SOCS1	1375	-2999
TAB2	2942	1892
TIRAP	2210	-5182
TLR1	4106	-6127
TLR2	4206	-6586
TLR6	4058	-802
TNIP2	2166	-5726
TRAF6	-80	-6118
UBA52	349	752
UBB	2759	-1321
UBC	1618	-2568
UBE2N	607	1127
UBE2V1	2209	-1021
VRK3	396	-1398

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.0   GGally_2.1.1    ggplot2_3.3.3   reshape2_1.4.4 
##  [5] beeswarm_0.3.1  gplots_3.1.1    gtools_3.8.2    tibble_3.1.0   
##  [9] dplyr_1.0.5     echarts4r_0.4.0 mitch_1.2.2    
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.6         rprojroot_2.0.2    assertthat_0.2.1   digest_0.6.27     
##  [5] utf8_1.2.1         mime_0.10          R6_2.5.0           plyr_1.8.6        
##  [9] evaluate_0.14      highr_0.8          pillar_1.5.1       rlang_0.4.10      
## [13] jquerylib_0.1.3    rmarkdown_2.7      labeling_0.4.2     desc_1.3.0        
## [17] stringr_1.4.0      htmlwidgets_1.5.3  munsell_0.5.0      shiny_1.6.0       
## [21] compiler_4.0.3     httpuv_1.5.5       xfun_0.22          pkgconfig_2.0.3   
## [25] htmltools_0.5.1.1  tidyselect_1.1.0   gridExtra_2.3      reshape_0.8.8     
## [29] fansi_0.4.2        crayon_1.4.1       withr_2.4.1        later_1.1.0.1     
## [33] MASS_7.3-53.1      bitops_1.0-6       grid_4.0.3         jsonlite_1.7.2    
## [37] xtable_1.8-4       gtable_0.3.0       lifecycle_1.0.0    DBI_1.1.1         
## [41] magrittr_2.0.1     scales_1.1.1       KernSmooth_2.23-18 stringi_1.5.3     
## [45] farver_2.1.0       promises_1.2.0.1   testthat_3.0.2     bslib_0.2.4       
## [49] ellipsis_0.3.1     generics_0.1.0     vctrs_0.3.6        RColorBrewer_1.1-2
## [53] tools_4.0.3        glue_1.4.2         purrr_0.3.4        parallel_4.0.3    
## [57] fastmap_1.1.0      yaml_2.2.1         colorspace_2.0-0   caTools_1.18.1    
## [61] knitr_1.31         sass_0.3.1

END of report