Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2021-04-20
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## low CRP high CRP
## A1BG 1.3448650 1.7900749
## A1BG-AS1 0.6121583 0.2690665
## A1CF 0.3948857 0.1941578
## A2M -1.2249521 -2.9774271
## A2M-AS1 -1.3083997 -2.2977591
## A2ML1 -0.7528612 -0.4068597Here are some metrics about the input data profile:
| Profile metrics | |
|---|---|
| num_genes_in_profile | 21404 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 8378 |
| num_profile_genes_not_in_sets | 13026 |
| profile_pearson_correl | 0.64689 |
| profile_spearman_correl | 0.59772 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
| Gene sets metrics | |
|---|---|
| num_genesets | 2408 |
| num_genesets_excluded | 1045 |
| num_genesets_included | 1363 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 586 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
Top N sets irrespective of FDR. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 50 gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.low.CRP | s.high.CRP | p.low.CRP | p.high.CRP |
|---|---|---|---|---|---|---|---|---|
| Scavenging of heme from plasma | 70 | 3.83e-27 | 7.46e-25 | 0.513 | 0.19200 | -0.4760 | 5.38e-03 | 5.82e-12 |
| Classical antibody-mediated complement activation | 68 | 3.04e-23 | 4.60e-21 | 0.517 | 0.09860 | -0.5070 | 1.60e-01 | 4.48e-13 |
| CD22 mediated BCR regulation | 58 | 2.23e-20 | 1.90e-18 | 0.539 | 0.06900 | -0.5340 | 3.63e-01 | 1.87e-12 |
| Creation of C4 and C2 activators | 70 | 8.44e-23 | 9.58e-21 | 0.497 | 0.11200 | -0.4840 | 1.06e-01 | 2.41e-12 |
| FCGR activation | 75 | 8.30e-23 | 9.58e-21 | 0.494 | 0.07990 | -0.4880 | 2.31e-01 | 2.73e-13 |
| Initial triggering of complement | 77 | 1.26e-22 | 1.32e-20 | 0.471 | 0.10900 | -0.4580 | 9.93e-02 | 3.62e-12 |
| Role of LAT2/NTAL/LAB on calcium mobilization | 73 | 1.98e-19 | 1.30e-17 | 0.426 | 0.15000 | -0.3990 | 2.71e-02 | 3.62e-09 |
| Binding and Uptake of Ligands by Scavenger Receptors | 91 | 2.01e-19 | 1.30e-17 | 0.360 | 0.21400 | -0.2890 | 4.13e-04 | 1.92e-06 |
| Purine ribonucleoside monophosphate biosynthesis | 10 | 9.57e-03 | 2.60e-02 | 0.354 | 0.27000 | -0.2290 | 1.39e-01 | 2.11e-01 |
| Regulation of Complement cascade | 93 | 1.30e-19 | 9.59e-18 | 0.366 | 0.17400 | -0.3220 | 3.80e-03 | 7.80e-08 |
| HDMs demethylate histones | 22 | 4.72e-05 | 2.26e-04 | 0.349 | -0.22800 | 0.2650 | 6.42e-02 | 3.16e-02 |
| Trafficking of GluR2-containing AMPA receptors | 12 | 4.26e-04 | 1.62e-03 | 0.577 | 0.08170 | 0.5710 | 6.24e-01 | 6.10e-04 |
| Complement cascade | 97 | 2.43e-19 | 1.51e-17 | 0.356 | 0.16900 | -0.3130 | 3.96e-03 | 1.00e-07 |
| Nucleobase biosynthesis | 13 | 3.62e-03 | 1.10e-02 | 0.349 | 0.17600 | -0.3020 | 2.73e-01 | 5.94e-02 |
| Removal of the Flap Intermediate | 14 | 1.54e-03 | 5.14e-03 | 0.410 | 0.06240 | -0.4050 | 6.86e-01 | 8.67e-03 |
| Pre-NOTCH Processing in Golgi | 18 | 2.11e-04 | 8.52e-04 | 0.420 | -0.05060 | 0.4170 | 7.10e-01 | 2.20e-03 |
| Processive synthesis on the lagging strand | 15 | 8.16e-04 | 2.92e-03 | 0.438 | 0.02130 | -0.4380 | 8.86e-01 | 3.33e-03 |
| Role of phospholipids in phagocytosis | 87 | 3.75e-17 | 1.89e-15 | 0.401 | 0.05440 | -0.3970 | 3.81e-01 | 1.45e-10 |
| Elevation of cytosolic Ca2+ levels | 12 | 1.46e-02 | 3.73e-02 | 0.309 | -0.24200 | 0.1920 | 1.47e-01 | 2.49e-01 |
| FCERI mediated MAPK activation | 89 | 2.28e-14 | 7.96e-13 | 0.318 | 0.15200 | -0.2790 | 1.29e-02 | 5.51e-06 |
| FCERI mediated Ca+2 mobilization | 88 | 1.90e-14 | 6.96e-13 | 0.360 | 0.05860 | -0.3550 | 3.42e-01 | 8.57e-09 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | 22 | 5.74e-05 | 2.71e-04 | 0.472 | 0.05800 | 0.4680 | 6.38e-01 | 1.42e-04 |
| PCNA-Dependent Long Patch Base Excision Repair | 21 | 5.45e-04 | 2.04e-03 | 0.388 | 0.00603 | -0.3880 | 9.62e-01 | 2.08e-03 |
| WNT5A-dependent internalization of FZD4 | 13 | 1.81e-03 | 5.91e-03 | 0.540 | 0.13300 | 0.5230 | 4.05e-01 | 1.09e-03 |
| Lagging Strand Synthesis | 20 | 5.76e-04 | 2.14e-03 | 0.415 | -0.02540 | -0.4150 | 8.44e-01 | 1.33e-03 |
| FCGR3A-mediated IL10 synthesis | 98 | 8.68e-14 | 2.75e-12 | 0.334 | 0.05210 | -0.3300 | 3.72e-01 | 1.69e-08 |
| RORA activates gene expression | 18 | 5.02e-03 | 1.47e-02 | 0.316 | -0.07080 | 0.3080 | 6.03e-01 | 2.36e-02 |
| Eukaryotic Translation Elongation | 92 | 2.03e-12 | 5.22e-11 | 0.316 | 0.07080 | -0.3080 | 2.40e-01 | 3.33e-07 |
| FCERI mediated NF-kB activation | 136 | 3.65e-17 | 1.89e-15 | 0.300 | 0.28800 | -0.0861 | 6.79e-09 | 8.32e-02 |
| Folding of actin by CCT/TriC | 10 | 4.78e-03 | 1.42e-02 | 0.603 | 0.57000 | 0.1970 | 1.81e-03 | 2.80e-01 |
| Peptide chain elongation | 87 | 1.87e-11 | 3.76e-10 | 0.315 | 0.06170 | -0.3090 | 3.20e-01 | 6.31e-07 |
| Formation of a pool of free 40S subunits | 99 | 7.31e-12 | 1.66e-10 | 0.272 | 0.13000 | -0.2400 | 2.59e-02 | 3.76e-05 |
| Viral mRNA Translation | 87 | 5.41e-11 | 9.57e-10 | 0.298 | 0.08120 | -0.2870 | 1.90e-01 | 3.71e-06 |
| TNFs bind their physiological receptors | 25 | 1.50e-03 | 5.03e-03 | 0.282 | 0.10200 | -0.2630 | 3.76e-01 | 2.30e-02 |
| GAB1 signalosome | 14 | 2.64e-03 | 8.34e-03 | 0.505 | 0.12600 | 0.4890 | 4.15e-01 | 1.52e-03 |
| Selenocysteine synthesis | 91 | 1.16e-11 | 2.55e-10 | 0.318 | 0.04660 | -0.3150 | 4.43e-01 | 2.04e-07 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 83 | 5.94e-11 | 1.04e-09 | 0.336 | 0.02260 | -0.3350 | 7.21e-01 | 1.29e-07 |
| Formation of the ternary complex, and subsequently, the 43S complex | 51 | 6.50e-06 | 3.68e-05 | 0.254 | 0.20900 | -0.1440 | 9.78e-03 | 7.49e-02 |
| Eukaryotic Translation Termination | 91 | 9.00e-11 | 1.50e-09 | 0.296 | 0.06280 | -0.2890 | 3.01e-01 | 1.85e-06 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 93 | 1.52e-10 | 2.25e-09 | 0.278 | 0.08730 | -0.2630 | 1.46e-01 | 1.13e-05 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | 25 | 2.75e-03 | 8.62e-03 | 0.264 | -0.11000 | 0.2400 | 3.43e-01 | 3.77e-02 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 99 | 6.63e-11 | 1.13e-09 | 0.269 | 0.09950 | -0.2490 | 8.70e-02 | 1.79e-05 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 109 | 2.64e-11 | 4.87e-10 | 0.245 | 0.17400 | -0.1730 | 1.66e-03 | 1.86e-03 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 110 | 2.25e-11 | 4.33e-10 | 0.245 | 0.17200 | -0.1740 | 1.80e-03 | 1.60e-03 |
| tRNA processing in the mitochondrion | 32 | 3.00e-04 | 1.18e-03 | 0.306 | -0.30300 | 0.0416 | 2.98e-03 | 6.84e-01 |
| Platelet calcium homeostasis | 21 | 1.08e-02 | 2.90e-02 | 0.241 | -0.15500 | 0.1850 | 2.19e-01 | 1.43e-01 |
| Processing of SMDT1 | 15 | 9.49e-03 | 2.58e-02 | 0.400 | 0.39600 | 0.0568 | 7.92e-03 | 7.03e-01 |
| rRNA processing in the nucleus and cytosol | 189 | 1.34e-19 | 9.59e-18 | 0.279 | 0.06610 | -0.2710 | 1.17e-01 | 1.30e-10 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 11 | 1.17e-04 | 5.01e-04 | 0.842 | 0.40300 | 0.7390 | 2.06e-02 | 2.17e-05 |
| SRP-dependent cotranslational protein targeting to membrane | 110 | 8.81e-11 | 1.48e-09 | 0.239 | 0.18700 | -0.1490 | 6.95e-04 | 6.94e-03 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.low.CRP | s.high.CRP | p.low.CRP | p.high.CRP |
|---|---|---|---|---|---|---|---|---|
| Scavenging of heme from plasma | 70 | 3.83e-27 | 7.46e-25 | 0.5130 | 0.192000 | -0.476000 | 5.38e-03 | 5.82e-12 |
| Classical antibody-mediated complement activation | 68 | 3.04e-23 | 4.60e-21 | 0.5170 | 0.098600 | -0.507000 | 1.60e-01 | 4.48e-13 |
| CD22 mediated BCR regulation | 58 | 2.23e-20 | 1.90e-18 | 0.5390 | 0.069000 | -0.534000 | 3.63e-01 | 1.87e-12 |
| Creation of C4 and C2 activators | 70 | 8.44e-23 | 9.58e-21 | 0.4970 | 0.112000 | -0.484000 | 1.06e-01 | 2.41e-12 |
| FCGR activation | 75 | 8.30e-23 | 9.58e-21 | 0.4940 | 0.079900 | -0.488000 | 2.31e-01 | 2.73e-13 |
| Initial triggering of complement | 77 | 1.26e-22 | 1.32e-20 | 0.4710 | 0.109000 | -0.458000 | 9.93e-02 | 3.62e-12 |
| Role of LAT2/NTAL/LAB on calcium mobilization | 73 | 1.98e-19 | 1.30e-17 | 0.4260 | 0.150000 | -0.399000 | 2.71e-02 | 3.62e-09 |
| Binding and Uptake of Ligands by Scavenger Receptors | 91 | 2.01e-19 | 1.30e-17 | 0.3600 | 0.214000 | -0.289000 | 4.13e-04 | 1.92e-06 |
| Purine ribonucleoside monophosphate biosynthesis | 10 | 9.57e-03 | 2.60e-02 | 0.3540 | 0.270000 | -0.229000 | 1.39e-01 | 2.11e-01 |
| Regulation of Complement cascade | 93 | 1.30e-19 | 9.59e-18 | 0.3660 | 0.174000 | -0.322000 | 3.80e-03 | 7.80e-08 |
| HDMs demethylate histones | 22 | 4.72e-05 | 2.26e-04 | 0.3490 | -0.228000 | 0.265000 | 6.42e-02 | 3.16e-02 |
| Trafficking of GluR2-containing AMPA receptors | 12 | 4.26e-04 | 1.62e-03 | 0.5770 | 0.081700 | 0.571000 | 6.24e-01 | 6.10e-04 |
| Complement cascade | 97 | 2.43e-19 | 1.51e-17 | 0.3560 | 0.169000 | -0.313000 | 3.96e-03 | 1.00e-07 |
| Nucleobase biosynthesis | 13 | 3.62e-03 | 1.10e-02 | 0.3490 | 0.176000 | -0.302000 | 2.73e-01 | 5.94e-02 |
| Removal of the Flap Intermediate | 14 | 1.54e-03 | 5.14e-03 | 0.4100 | 0.062400 | -0.405000 | 6.86e-01 | 8.67e-03 |
| Pre-NOTCH Processing in Golgi | 18 | 2.11e-04 | 8.52e-04 | 0.4200 | -0.050600 | 0.417000 | 7.10e-01 | 2.20e-03 |
| Processive synthesis on the lagging strand | 15 | 8.16e-04 | 2.92e-03 | 0.4380 | 0.021300 | -0.438000 | 8.86e-01 | 3.33e-03 |
| Role of phospholipids in phagocytosis | 87 | 3.75e-17 | 1.89e-15 | 0.4010 | 0.054400 | -0.397000 | 3.81e-01 | 1.45e-10 |
| Elevation of cytosolic Ca2+ levels | 12 | 1.46e-02 | 3.73e-02 | 0.3090 | -0.242000 | 0.192000 | 1.47e-01 | 2.49e-01 |
| FCERI mediated MAPK activation | 89 | 2.28e-14 | 7.96e-13 | 0.3180 | 0.152000 | -0.279000 | 1.29e-02 | 5.51e-06 |
| FCERI mediated Ca+2 mobilization | 88 | 1.90e-14 | 6.96e-13 | 0.3600 | 0.058600 | -0.355000 | 3.42e-01 | 8.57e-09 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | 22 | 5.74e-05 | 2.71e-04 | 0.4720 | 0.058000 | 0.468000 | 6.38e-01 | 1.42e-04 |
| PCNA-Dependent Long Patch Base Excision Repair | 21 | 5.45e-04 | 2.04e-03 | 0.3880 | 0.006030 | -0.388000 | 9.62e-01 | 2.08e-03 |
| WNT5A-dependent internalization of FZD4 | 13 | 1.81e-03 | 5.91e-03 | 0.5400 | 0.133000 | 0.523000 | 4.05e-01 | 1.09e-03 |
| Lagging Strand Synthesis | 20 | 5.76e-04 | 2.14e-03 | 0.4150 | -0.025400 | -0.415000 | 8.44e-01 | 1.33e-03 |
| FCGR3A-mediated IL10 synthesis | 98 | 8.68e-14 | 2.75e-12 | 0.3340 | 0.052100 | -0.330000 | 3.72e-01 | 1.69e-08 |
| RORA activates gene expression | 18 | 5.02e-03 | 1.47e-02 | 0.3160 | -0.070800 | 0.308000 | 6.03e-01 | 2.36e-02 |
| Eukaryotic Translation Elongation | 92 | 2.03e-12 | 5.22e-11 | 0.3160 | 0.070800 | -0.308000 | 2.40e-01 | 3.33e-07 |
| FCERI mediated NF-kB activation | 136 | 3.65e-17 | 1.89e-15 | 0.3000 | 0.288000 | -0.086100 | 6.79e-09 | 8.32e-02 |
| Folding of actin by CCT/TriC | 10 | 4.78e-03 | 1.42e-02 | 0.6030 | 0.570000 | 0.197000 | 1.81e-03 | 2.80e-01 |
| Peptide chain elongation | 87 | 1.87e-11 | 3.76e-10 | 0.3150 | 0.061700 | -0.309000 | 3.20e-01 | 6.31e-07 |
| Formation of a pool of free 40S subunits | 99 | 7.31e-12 | 1.66e-10 | 0.2720 | 0.130000 | -0.240000 | 2.59e-02 | 3.76e-05 |
| Viral mRNA Translation | 87 | 5.41e-11 | 9.57e-10 | 0.2980 | 0.081200 | -0.287000 | 1.90e-01 | 3.71e-06 |
| TNFs bind their physiological receptors | 25 | 1.50e-03 | 5.03e-03 | 0.2820 | 0.102000 | -0.263000 | 3.76e-01 | 2.30e-02 |
| GAB1 signalosome | 14 | 2.64e-03 | 8.34e-03 | 0.5050 | 0.126000 | 0.489000 | 4.15e-01 | 1.52e-03 |
| Selenocysteine synthesis | 91 | 1.16e-11 | 2.55e-10 | 0.3180 | 0.046600 | -0.315000 | 4.43e-01 | 2.04e-07 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 83 | 5.94e-11 | 1.04e-09 | 0.3360 | 0.022600 | -0.335000 | 7.21e-01 | 1.29e-07 |
| Formation of the ternary complex, and subsequently, the 43S complex | 51 | 6.50e-06 | 3.68e-05 | 0.2540 | 0.209000 | -0.144000 | 9.78e-03 | 7.49e-02 |
| Eukaryotic Translation Termination | 91 | 9.00e-11 | 1.50e-09 | 0.2960 | 0.062800 | -0.289000 | 3.01e-01 | 1.85e-06 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 93 | 1.52e-10 | 2.25e-09 | 0.2780 | 0.087300 | -0.263000 | 1.46e-01 | 1.13e-05 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | 25 | 2.75e-03 | 8.62e-03 | 0.2640 | -0.110000 | 0.240000 | 3.43e-01 | 3.77e-02 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 99 | 6.63e-11 | 1.13e-09 | 0.2690 | 0.099500 | -0.249000 | 8.70e-02 | 1.79e-05 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 109 | 2.64e-11 | 4.87e-10 | 0.2450 | 0.174000 | -0.173000 | 1.66e-03 | 1.86e-03 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 110 | 2.25e-11 | 4.33e-10 | 0.2450 | 0.172000 | -0.174000 | 1.80e-03 | 1.60e-03 |
| tRNA processing in the mitochondrion | 32 | 3.00e-04 | 1.18e-03 | 0.3060 | -0.303000 | 0.041600 | 2.98e-03 | 6.84e-01 |
| Platelet calcium homeostasis | 21 | 1.08e-02 | 2.90e-02 | 0.2410 | -0.155000 | 0.185000 | 2.19e-01 | 1.43e-01 |
| Processing of SMDT1 | 15 | 9.49e-03 | 2.58e-02 | 0.4000 | 0.396000 | 0.056800 | 7.92e-03 | 7.03e-01 |
| rRNA processing in the nucleus and cytosol | 189 | 1.34e-19 | 9.59e-18 | 0.2790 | 0.066100 | -0.271000 | 1.17e-01 | 1.30e-10 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 11 | 1.17e-04 | 5.01e-04 | 0.8420 | 0.403000 | 0.739000 | 2.06e-02 | 2.17e-05 |
| SRP-dependent cotranslational protein targeting to membrane | 110 | 8.81e-11 | 1.48e-09 | 0.2390 | 0.187000 | -0.149000 | 6.95e-04 | 6.94e-03 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 179 | 2.42e-18 | 1.38e-16 | 0.2760 | 0.066800 | -0.268000 | 1.23e-01 | 6.03e-10 |
| Selenoamino acid metabolism | 113 | 2.35e-11 | 4.45e-10 | 0.2550 | 0.100000 | -0.235000 | 6.63e-02 | 1.62e-05 |
| Cytosolic tRNA aminoacylation | 24 | 1.78e-03 | 5.85e-03 | 0.3420 | 0.341000 | 0.008680 | 3.79e-03 | 9.41e-01 |
| VLDLR internalisation and degradation | 11 | 9.92e-03 | 2.68e-02 | 0.5320 | 0.171000 | 0.503000 | 3.26e-01 | 3.83e-03 |
| Mitochondrial iron-sulfur cluster biogenesis | 13 | 3.51e-03 | 1.07e-02 | 0.5560 | 0.520000 | 0.197000 | 1.18e-03 | 2.19e-01 |
| Cap-dependent Translation Initiation | 117 | 1.50e-10 | 2.24e-09 | 0.2290 | 0.174000 | -0.149000 | 1.17e-03 | 5.42e-03 |
| Eukaryotic Translation Initiation | 117 | 1.50e-10 | 2.24e-09 | 0.2290 | 0.174000 | -0.149000 | 1.17e-03 | 5.42e-03 |
| Translation initiation complex formation | 58 | 7.17e-06 | 4.01e-05 | 0.2570 | 0.246000 | -0.074100 | 1.20e-03 | 3.29e-01 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 24 | 9.59e-04 | 3.35e-03 | 0.3990 | -0.075300 | -0.392000 | 5.23e-01 | 8.80e-04 |
| rRNA modification in the nucleus and cytosol | 59 | 2.54e-06 | 1.56e-05 | 0.2900 | 0.027300 | -0.289000 | 7.17e-01 | 1.22e-04 |
| PD-1 signaling | 28 | 2.29e-09 | 2.38e-08 | 0.7810 | -0.372000 | -0.687000 | 6.63e-04 | 3.12e-10 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 59 | 6.94e-06 | 3.89e-05 | 0.2600 | 0.253000 | -0.061800 | 7.78e-04 | 4.12e-01 |
| Ribosomal scanning and start codon recognition | 58 | 1.35e-05 | 7.15e-05 | 0.2480 | 0.236000 | -0.076000 | 1.85e-03 | 3.17e-01 |
| Packaging Of Telomere Ends | 20 | 8.89e-04 | 3.15e-03 | 0.4810 | 0.148000 | 0.458000 | 2.53e-01 | 3.92e-04 |
| Metabolism of Angiotensinogen to Angiotensins | 11 | 9.60e-03 | 2.60e-02 | 0.5550 | 0.515000 | 0.205000 | 3.09e-03 | 2.38e-01 |
| HDACs deacetylate histones | 47 | 4.33e-06 | 2.51e-05 | 0.3730 | 0.059700 | 0.368000 | 4.79e-01 | 1.26e-05 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | 36 | 1.51e-03 | 5.05e-03 | 0.2270 | -0.108000 | 0.200000 | 2.61e-01 | 3.81e-02 |
| EGFR downregulation | 26 | 1.48e-04 | 6.24e-04 | 0.4750 | 0.148000 | 0.451000 | 1.90e-01 | 6.85e-05 |
| Termination of translesion DNA synthesis | 32 | 4.09e-03 | 1.22e-02 | 0.2230 | 0.100000 | -0.199000 | 3.26e-01 | 5.09e-02 |
| Pre-NOTCH Expression and Processing | 65 | 4.84e-07 | 3.40e-06 | 0.3280 | 0.028700 | 0.326000 | 6.89e-01 | 5.36e-06 |
| DNA strand elongation | 32 | 3.43e-06 | 2.03e-05 | 0.5370 | -0.201000 | -0.498000 | 4.96e-02 | 1.09e-06 |
| N-glycan antennae elongation in the medial/trans-Golgi | 21 | 1.77e-02 | 4.40e-02 | 0.2730 | -0.272000 | 0.023600 | 3.08e-02 | 8.51e-01 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | 32 | 4.87e-03 | 1.44e-02 | 0.2260 | -0.080400 | 0.211000 | 4.31e-01 | 3.86e-02 |
| PIWI-interacting RNA (piRNA) biogenesis | 24 | 8.71e-03 | 2.39e-02 | 0.2910 | 0.291000 | -0.000729 | 1.37e-02 | 9.95e-01 |
| PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | 13 | 5.42e-04 | 2.04e-03 | 0.7020 | 0.331000 | 0.619000 | 3.86e-02 | 1.10e-04 |
| Pre-NOTCH Transcription and Translation | 49 | 3.38e-05 | 1.65e-04 | 0.3200 | 0.032000 | 0.318000 | 6.98e-01 | 1.15e-04 |
| Influenza Viral RNA Transcription and Replication | 134 | 3.86e-10 | 5.10e-09 | 0.2330 | 0.056100 | -0.227000 | 2.62e-01 | 5.91e-06 |
| DNA methylation | 20 | 2.76e-03 | 8.64e-03 | 0.4470 | 0.146000 | 0.423000 | 2.58e-01 | 1.06e-03 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | 53 | 1.79e-04 | 7.36e-04 | 0.2470 | -0.031200 | 0.245000 | 6.94e-01 | 2.07e-03 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 113 | 6.37e-08 | 5.05e-07 | 0.2140 | 0.071000 | -0.202000 | 1.93e-01 | 2.03e-04 |
| Nonsense-Mediated Decay (NMD) | 113 | 6.37e-08 | 5.05e-07 | 0.2140 | 0.071000 | -0.202000 | 1.93e-01 | 2.03e-04 |
| G1/S-Specific Transcription | 29 | 1.78e-02 | 4.42e-02 | 0.1940 | 0.120000 | -0.152000 | 2.62e-01 | 1.56e-01 |
| Retrograde neurotrophin signalling | 12 | 5.63e-03 | 1.63e-02 | 0.5920 | 0.260000 | 0.532000 | 1.19e-01 | 1.43e-03 |
| RNA Polymerase I Promoter Opening | 19 | 1.59e-04 | 6.63e-04 | 0.6180 | 0.280000 | 0.551000 | 3.43e-02 | 3.22e-05 |
| GPVI-mediated activation cascade | 31 | 1.47e-03 | 4.95e-03 | 0.3410 | 0.064600 | 0.335000 | 5.33e-01 | 1.26e-03 |
| Translocation of ZAP-70 to Immunological synapse | 24 | 2.61e-11 | 4.87e-10 | 0.9870 | -0.550000 | -0.819000 | 3.10e-06 | 3.60e-12 |
| Response of EIF2AK1 (HRI) to heme deficiency | 14 | 3.56e-03 | 1.09e-02 | 0.5670 | 0.512000 | 0.243000 | 9.04e-04 | 1.16e-01 |
| Activation of the pre-replicative complex | 32 | 4.51e-05 | 2.17e-04 | 0.4760 | -0.174000 | -0.443000 | 8.85e-02 | 1.46e-05 |
| Translation | 294 | 4.72e-20 | 3.78e-18 | 0.2420 | 0.241000 | -0.024300 | 1.16e-12 | 4.74e-01 |
| TNFR2 non-canonical NF-kB pathway | 95 | 6.89e-10 | 8.24e-09 | 0.3650 | 0.354000 | 0.089200 | 2.46e-09 | 1.33e-01 |
| Signal transduction by L1 | 20 | 3.61e-04 | 1.40e-03 | 0.5650 | 0.246000 | 0.509000 | 5.72e-02 | 8.12e-05 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 32 | 5.98e-03 | 1.71e-02 | 0.2600 | -0.003330 | 0.260000 | 9.74e-01 | 1.09e-02 |
| Signaling by WNT in cancer | 30 | 2.09e-02 | 4.88e-02 | 0.1880 | -0.152000 | 0.111000 | 1.51e-01 | 2.94e-01 |
| tRNA modification in the nucleus and cytosol | 43 | 3.08e-03 | 9.58e-03 | 0.2040 | 0.070100 | -0.192000 | 4.27e-01 | 2.96e-02 |
| Platelet sensitization by LDL | 16 | 3.03e-04 | 1.19e-03 | 0.6620 | 0.319000 | 0.580000 | 2.69e-02 | 5.85e-05 |
| rRNA processing | 218 | 9.52e-15 | 3.71e-13 | 0.2420 | 0.018600 | -0.241000 | 6.36e-01 | 7.96e-10 |
| Cleavage of the damaged purine | 24 | 4.05e-03 | 1.21e-02 | 0.3810 | 0.106000 | 0.366000 | 3.68e-01 | 1.93e-03 |
| Depurination | 24 | 4.05e-03 | 1.21e-02 | 0.3810 | 0.106000 | 0.366000 | 3.68e-01 | 1.93e-03 |
| Recognition and association of DNA glycosylase with site containing an affected purine | 24 | 4.05e-03 | 1.21e-02 | 0.3810 | 0.106000 | 0.366000 | 3.68e-01 | 1.93e-03 |
| Regulation of actin dynamics for phagocytic cup formation | 122 | 1.16e-07 | 9.04e-07 | 0.2070 | 0.199000 | -0.057500 | 1.52e-04 | 2.73e-01 |
| Regulation of TP53 Activity through Acetylation | 29 | 6.70e-04 | 2.46e-03 | 0.4150 | -0.392000 | -0.137000 | 2.61e-04 | 2.02e-01 |
| Activation of HOX genes during differentiation | 69 | 1.05e-04 | 4.69e-04 | 0.2130 | -0.046300 | 0.208000 | 5.06e-01 | 2.78e-03 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | 69 | 1.05e-04 | 4.69e-04 | 0.2130 | -0.046300 | 0.208000 | 5.06e-01 | 2.78e-03 |
| Recycling pathway of L1 | 26 | 4.84e-04 | 1.83e-03 | 0.4660 | 0.178000 | 0.431000 | 1.17e-01 | 1.41e-04 |
| Notch-HLH transcription pathway | 28 | 1.08e-03 | 3.71e-03 | 0.4060 | 0.132000 | 0.384000 | 2.28e-01 | 4.30e-04 |
| Influenza Infection | 153 | 6.30e-09 | 5.80e-08 | 0.1940 | 0.072300 | -0.180000 | 1.23e-01 | 1.20e-04 |
| Telomere C-strand (Lagging Strand) Synthesis | 34 | 1.14e-03 | 3.88e-03 | 0.3460 | -0.085600 | -0.336000 | 3.88e-01 | 7.08e-04 |
| FCGR3A-mediated phagocytosis | 120 | 7.02e-07 | 4.78e-06 | 0.1860 | 0.167000 | -0.081300 | 1.55e-03 | 1.24e-01 |
| Leishmania phagocytosis | 120 | 7.02e-07 | 4.78e-06 | 0.1860 | 0.167000 | -0.081300 | 1.55e-03 | 1.24e-01 |
| Parasite infection | 120 | 7.02e-07 | 4.78e-06 | 0.1860 | 0.167000 | -0.081300 | 1.55e-03 | 1.24e-01 |
| NR1H2 and NR1H3-mediated signaling | 38 | 9.32e-03 | 2.55e-02 | 0.1990 | -0.057800 | 0.191000 | 5.38e-01 | 4.21e-02 |
| Metabolism of non-coding RNA | 53 | 1.56e-03 | 5.18e-03 | 0.1960 | 0.062000 | -0.186000 | 4.35e-01 | 1.89e-02 |
| snRNP Assembly | 53 | 1.56e-03 | 5.18e-03 | 0.1960 | 0.062000 | -0.186000 | 4.35e-01 | 1.89e-02 |
| PINK1-PRKN Mediated Mitophagy | 21 | 6.01e-03 | 1.71e-02 | 0.4100 | 0.386000 | 0.138000 | 2.19e-03 | 2.73e-01 |
| Regulation of expression of SLITs and ROBOs | 158 | 2.12e-09 | 2.28e-08 | 0.2120 | 0.208000 | -0.039300 | 6.50e-06 | 3.94e-01 |
| Interconversion of nucleotide di- and triphosphates | 27 | 5.16e-03 | 1.51e-02 | 0.3430 | 0.332000 | 0.086300 | 2.79e-03 | 4.37e-01 |
| Anti-inflammatory response favouring Leishmania parasite infection | 167 | 2.24e-09 | 2.35e-08 | 0.1970 | 0.055900 | -0.189000 | 2.13e-01 | 2.51e-05 |
| Leishmania parasite growth and survival | 167 | 2.24e-09 | 2.35e-08 | 0.1970 | 0.055900 | -0.189000 | 2.13e-01 | 2.51e-05 |
| Effects of PIP2 hydrolysis | 24 | 4.50e-04 | 1.71e-03 | 0.5030 | -0.457000 | -0.212000 | 1.08e-04 | 7.23e-02 |
| rRNA processing in the mitochondrion | 29 | 9.05e-03 | 2.48e-02 | 0.2930 | -0.289000 | -0.046200 | 7.09e-03 | 6.67e-01 |
| RHO GTPases activate PKNs | 47 | 7.63e-07 | 5.17e-06 | 0.4830 | 0.198000 | 0.440000 | 1.87e-02 | 1.78e-07 |
| Activation of ATR in response to replication stress | 36 | 9.21e-05 | 4.16e-04 | 0.4350 | -0.162000 | -0.403000 | 9.21e-02 | 2.81e-05 |
| RHO GTPases activate IQGAPs | 11 | 1.03e-02 | 2.77e-02 | 0.5980 | 0.285000 | 0.526000 | 1.02e-01 | 2.54e-03 |
| ATF6 (ATF6-alpha) activates chaperone genes | 10 | 1.12e-02 | 2.98e-02 | 0.6260 | 0.546000 | 0.306000 | 2.76e-03 | 9.36e-02 |
| TBC/RABGAPs | 45 | 4.21e-04 | 1.61e-03 | 0.3140 | 0.067000 | 0.307000 | 4.37e-01 | 3.66e-04 |
| MET activates RAP1 and RAC1 | 10 | 6.88e-03 | 1.94e-02 | 0.6680 | 0.338000 | 0.576000 | 6.44e-02 | 1.60e-03 |
| Signaling by the B Cell Receptor (BCR) | 161 | 1.28e-08 | 1.14e-07 | 0.1940 | 0.187000 | -0.049900 | 4.15e-05 | 2.75e-01 |
| Fc epsilon receptor (FCERI) signaling | 189 | 2.09e-11 | 4.07e-10 | 0.2370 | 0.237000 | 0.000690 | 1.79e-08 | 9.87e-01 |
| Mitochondrial calcium ion transport | 22 | 1.50e-02 | 3.82e-02 | 0.3470 | 0.333000 | 0.097400 | 6.77e-03 | 4.29e-01 |
| Mitochondrial translation elongation | 91 | 1.30e-06 | 8.38e-06 | 0.2800 | 0.277000 | 0.043700 | 5.00e-06 | 4.71e-01 |
| Mitochondrial translation termination | 91 | 1.20e-06 | 7.90e-06 | 0.2840 | 0.280000 | 0.048600 | 3.93e-06 | 4.23e-01 |
| Inflammasomes | 20 | 1.23e-04 | 5.29e-04 | 0.6350 | 0.548000 | 0.322000 | 2.21e-05 | 1.27e-02 |
| Cell surface interactions at the vascular wall | 172 | 1.95e-08 | 1.64e-07 | 0.1870 | 0.182000 | -0.044300 | 3.98e-05 | 3.16e-01 |
| Mitochondrial translation | 97 | 4.02e-07 | 2.90e-06 | 0.2950 | 0.288000 | 0.062300 | 9.55e-07 | 2.89e-01 |
| Synthesis of DNA | 118 | 1.63e-06 | 1.03e-05 | 0.2130 | 0.213000 | -0.012700 | 6.56e-05 | 8.12e-01 |
| Mitochondrial protein import | 64 | 5.86e-05 | 2.75e-04 | 0.2950 | 0.288000 | 0.063100 | 6.57e-05 | 3.83e-01 |
| VxPx cargo-targeting to cilium | 19 | 1.86e-02 | 4.51e-02 | 0.3850 | 0.135000 | 0.361000 | 3.07e-01 | 6.50e-03 |
| Intra-Golgi traffic | 43 | 9.12e-04 | 3.21e-03 | 0.3140 | 0.079100 | 0.304000 | 3.69e-01 | 5.64e-04 |
| Antimicrobial peptides | 33 | 1.16e-06 | 7.65e-06 | 0.6060 | 0.525000 | 0.302000 | 1.73e-07 | 2.70e-03 |
| IRAK1 recruits IKK complex | 10 | 8.50e-03 | 2.34e-02 | 0.6590 | 0.340000 | 0.564000 | 6.25e-02 | 2.02e-03 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 10 | 8.50e-03 | 2.34e-02 | 0.6590 | 0.340000 | 0.564000 | 6.25e-02 | 2.02e-03 |
| Mitochondrial translation initiation | 91 | 2.72e-06 | 1.64e-05 | 0.2770 | 0.273000 | 0.050000 | 6.89e-06 | 4.10e-01 |
| Generation of second messenger molecules | 38 | 4.49e-08 | 3.69e-07 | 0.6340 | -0.324000 | -0.545000 | 5.52e-04 | 5.99e-09 |
| RHO GTPases activate PAKs | 20 | 5.94e-03 | 1.70e-02 | 0.4480 | 0.187000 | 0.407000 | 1.49e-01 | 1.61e-03 |
| Platelet Aggregation (Plug Formation) | 28 | 3.46e-04 | 1.35e-03 | 0.4830 | 0.215000 | 0.432000 | 4.85e-02 | 7.44e-05 |
| SUMOylation of transcription cofactors | 44 | 2.14e-02 | 4.97e-02 | 0.1530 | -0.115000 | 0.102000 | 1.87e-01 | 2.43e-01 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | 46 | 1.61e-02 | 4.06e-02 | 0.1670 | -0.056500 | 0.157000 | 5.07e-01 | 6.49e-02 |
| PKMTs methylate histone lysines | 44 | 9.46e-03 | 2.58e-02 | 0.2140 | -0.214000 | -0.001080 | 1.41e-02 | 9.90e-01 |
| Metabolism of nucleotides | 86 | 1.33e-06 | 8.56e-06 | 0.3180 | 0.305000 | 0.092400 | 1.04e-06 | 1.38e-01 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 181 | 5.13e-12 | 1.21e-10 | 0.2960 | -0.075100 | -0.286000 | 8.15e-02 | 2.92e-11 |
| Vpr-mediated nuclear import of PICs | 34 | 9.98e-03 | 2.69e-02 | 0.2800 | -0.062700 | -0.273000 | 5.27e-01 | 5.81e-03 |
| DNA Double Strand Break Response | 47 | 1.83e-02 | 4.50e-02 | 0.1610 | -0.059400 | 0.150000 | 4.81e-01 | 7.58e-02 |
| Chaperone Mediated Autophagy | 19 | 1.65e-02 | 4.16e-02 | 0.4070 | 0.372000 | 0.163000 | 4.96e-03 | 2.17e-01 |
| tRNA processing in the nucleus | 59 | 2.35e-03 | 7.48e-03 | 0.2130 | -0.005320 | -0.213000 | 9.44e-01 | 4.64e-03 |
| DNA Replication | 125 | 4.26e-06 | 2.48e-05 | 0.2050 | 0.205000 | -0.002080 | 7.42e-05 | 9.68e-01 |
| Hyaluronan metabolism | 15 | 2.73e-03 | 8.58e-03 | 0.5970 | 0.306000 | 0.512000 | 4.02e-02 | 5.91e-04 |
| Cleavage of the damaged pyrimidine | 29 | 1.79e-02 | 4.42e-02 | 0.2910 | 0.074900 | 0.281000 | 4.85e-01 | 8.76e-03 |
| Depyrimidination | 29 | 1.79e-02 | 4.42e-02 | 0.2910 | 0.074900 | 0.281000 | 4.85e-01 | 8.76e-03 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | 29 | 1.79e-02 | 4.42e-02 | 0.2910 | 0.074900 | 0.281000 | 4.85e-01 | 8.76e-03 |
| SCF-beta-TrCP mediated degradation of Emi1 | 53 | 2.78e-09 | 2.85e-08 | 0.5770 | 0.498000 | 0.292000 | 3.46e-10 | 2.35e-04 |
| Peptide hormone metabolism | 49 | 1.33e-03 | 4.50e-03 | 0.2870 | 0.277000 | 0.072500 | 7.88e-04 | 3.80e-01 |
| Regulation of APC/C activators between G1/S and early anaphase | 79 | 2.22e-09 | 2.35e-08 | 0.4550 | 0.408000 | 0.203000 | 3.72e-10 | 1.79e-03 |
| Interactions of Rev with host cellular proteins | 37 | 6.24e-03 | 1.77e-02 | 0.2910 | -0.077000 | -0.281000 | 4.18e-01 | 3.13e-03 |
| Gap junction trafficking | 13 | 1.78e-02 | 4.42e-02 | 0.5180 | 0.250000 | 0.454000 | 1.18e-01 | 4.61e-03 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 72 | 1.07e-09 | 1.21e-08 | 0.4950 | 0.437000 | 0.234000 | 1.48e-10 | 5.99e-04 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 71 | 8.51e-10 | 9.91e-09 | 0.5040 | 0.442000 | 0.240000 | 1.13e-10 | 4.58e-04 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | 58 | 3.09e-10 | 4.13e-09 | 0.5850 | 0.502000 | 0.301000 | 3.64e-11 | 7.50e-05 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | 74 | 9.19e-10 | 1.05e-08 | 0.4900 | 0.432000 | 0.231000 | 1.27e-10 | 5.93e-04 |
| Resolution of Abasic Sites (AP sites) | 37 | 2.25e-03 | 7.19e-03 | 0.3400 | -0.118000 | -0.319000 | 2.14e-01 | 7.81e-04 |
| Interleukin-10 signaling | 35 | 1.62e-03 | 5.35e-03 | 0.3690 | 0.341000 | 0.140000 | 4.81e-04 | 1.52e-01 |
| Presynaptic phase of homologous DNA pairing and strand exchange | 39 | 5.52e-03 | 1.60e-02 | 0.2870 | -0.075800 | -0.277000 | 4.13e-01 | 2.79e-03 |
| Metabolism of polyamines | 57 | 1.84e-10 | 2.67e-09 | 0.6000 | 0.512000 | 0.312000 | 2.16e-11 | 4.49e-05 |
| Extension of Telomeres | 51 | 3.11e-03 | 9.65e-03 | 0.2490 | -0.045500 | -0.245000 | 5.74e-01 | 2.50e-03 |
| Butyrophilin (BTN) family interactions | 10 | 1.31e-02 | 3.41e-02 | 0.6350 | -0.339000 | -0.537000 | 6.38e-02 | 3.27e-03 |
| Orc1 removal from chromatin | 69 | 3.05e-06 | 1.82e-05 | 0.3720 | 0.343000 | 0.144000 | 8.55e-07 | 3.80e-02 |
| APC/C-mediated degradation of cell cycle proteins | 86 | 2.88e-09 | 2.88e-08 | 0.4320 | 0.388000 | 0.190000 | 5.07e-10 | 2.27e-03 |
| Regulation of mitotic cell cycle | 86 | 2.88e-09 | 2.88e-08 | 0.4320 | 0.388000 | 0.190000 | 5.07e-10 | 2.27e-03 |
| CDT1 association with the CDC6:ORC:origin complex | 57 | 1.64e-08 | 1.43e-07 | 0.5270 | 0.458000 | 0.261000 | 2.18e-09 | 6.58e-04 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 75 | 8.14e-10 | 9.56e-09 | 0.4900 | 0.431000 | 0.234000 | 1.08e-10 | 4.61e-04 |
| DNA Replication Pre-Initiation | 82 | 6.89e-05 | 3.16e-04 | 0.2600 | 0.253000 | 0.056800 | 7.26e-05 | 3.74e-01 |
| Interactions of Vpr with host cellular proteins | 37 | 1.12e-02 | 2.98e-02 | 0.2690 | -0.064500 | -0.261000 | 4.97e-01 | 6.04e-03 |
| Regulation of Apoptosis | 51 | 9.12e-11 | 1.50e-09 | 0.6530 | 0.549000 | 0.353000 | 1.13e-11 | 1.26e-05 |
| COPI-independent Golgi-to-ER retrograde traffic | 33 | 1.39e-08 | 1.23e-07 | 0.7260 | 0.406000 | 0.602000 | 5.34e-05 | 2.14e-09 |
| Chromatin modifying enzymes | 217 | 2.26e-07 | 1.67e-06 | 0.1380 | -0.097700 | 0.097800 | 1.32e-02 | 1.31e-02 |
| Chromatin organization | 217 | 2.26e-07 | 1.67e-06 | 0.1380 | -0.097700 | 0.097800 | 1.32e-02 | 1.31e-02 |
| NIK–>noncanonical NF-kB signaling | 57 | 1.30e-10 | 2.04e-09 | 0.6080 | 0.516000 | 0.321000 | 1.54e-11 | 2.68e-05 |
| G1/S Transition | 130 | 7.63e-06 | 4.16e-05 | 0.2030 | 0.203000 | 0.009170 | 6.42e-05 | 8.57e-01 |
| SCF(Skp2)-mediated degradation of p27/p21 | 60 | 2.96e-08 | 2.46e-07 | 0.5030 | 0.439000 | 0.246000 | 4.06e-09 | 9.92e-04 |
| Cell recruitment (pro-inflammatory response) | 22 | 9.65e-04 | 3.35e-03 | 0.5310 | 0.459000 | 0.267000 | 1.95e-04 | 3.02e-02 |
| Purinergic signaling in leishmaniasis infection | 22 | 9.65e-04 | 3.35e-03 | 0.5310 | 0.459000 | 0.267000 | 1.95e-04 | 3.02e-02 |
| Integrin signaling | 22 | 1.65e-03 | 5.43e-03 | 0.5060 | 0.249000 | 0.440000 | 4.34e-02 | 3.48e-04 |
| Activation of G protein gated Potassium channels | 20 | 1.88e-02 | 4.51e-02 | 0.3970 | 0.359000 | 0.168000 | 5.40e-03 | 1.94e-01 |
| G protein gated Potassium channels | 20 | 1.88e-02 | 4.51e-02 | 0.3970 | 0.359000 | 0.168000 | 5.40e-03 | 1.94e-01 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 20 | 1.88e-02 | 4.51e-02 | 0.3970 | 0.359000 | 0.168000 | 5.40e-03 | 1.94e-01 |
| Formation of the beta-catenin:TCF transactivating complex | 46 | 1.93e-02 | 4.60e-02 | 0.1950 | 0.004610 | 0.195000 | 9.57e-01 | 2.24e-02 |
| Rab regulation of trafficking | 120 | 7.18e-09 | 6.57e-08 | 0.3370 | 0.124000 | 0.314000 | 1.94e-02 | 2.93e-09 |
| Nuclear import of Rev protein | 34 | 1.30e-02 | 3.37e-02 | 0.2880 | -0.085200 | -0.275000 | 3.90e-01 | 5.52e-03 |
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 50 | 6.52e-10 | 7.87e-09 | 0.6310 | 0.531000 | 0.341000 | 8.37e-11 | 3.01e-05 |
| p53-Independent DNA Damage Response | 50 | 6.52e-10 | 7.87e-09 | 0.6310 | 0.531000 | 0.341000 | 8.37e-11 | 3.01e-05 |
| p53-Independent G1/S DNA damage checkpoint | 50 | 6.52e-10 | 7.87e-09 | 0.6310 | 0.531000 | 0.341000 | 8.37e-11 | 3.01e-05 |
| Fcgamma receptor (FCGR) dependent phagocytosis | 146 | 1.93e-05 | 9.94e-05 | 0.1620 | 0.160000 | -0.029700 | 8.62e-04 | 5.36e-01 |
| Dectin-1 mediated noncanonical NF-kB signaling | 58 | 2.75e-10 | 3.71e-09 | 0.5930 | 0.503000 | 0.314000 | 3.31e-11 | 3.56e-05 |
| Activation of gene expression by SREBF (SREBP) | 42 | 5.03e-03 | 1.47e-02 | 0.2850 | 0.083100 | 0.273000 | 3.51e-01 | 2.24e-03 |
| Autodegradation of the E3 ubiquitin ligase COP1 | 49 | 1.44e-08 | 1.27e-07 | 0.5830 | 0.496000 | 0.307000 | 1.89e-09 | 2.00e-04 |
| PPARA activates gene expression | 104 | 1.11e-07 | 8.72e-07 | 0.3350 | 0.123000 | 0.311000 | 2.96e-02 | 4.06e-08 |
| RAB GEFs exchange GTP for GDP on RABs | 87 | 1.19e-08 | 1.08e-07 | 0.4140 | 0.184000 | 0.371000 | 3.08e-03 | 2.09e-09 |
| Homologous DNA Pairing and Strand Exchange | 42 | 2.28e-03 | 7.27e-03 | 0.3200 | -0.112000 | -0.300000 | 2.09e-01 | 7.81e-04 |
| Vpu mediated degradation of CD4 | 50 | 1.44e-09 | 1.60e-08 | 0.6180 | 0.521000 | 0.334000 | 1.87e-10 | 4.41e-05 |
| RIPK1-mediated regulated necrosis | 29 | 1.97e-02 | 4.64e-02 | 0.3050 | 0.288000 | 0.102000 | 7.34e-03 | 3.44e-01 |
| Regulated Necrosis | 29 | 1.97e-02 | 4.64e-02 | 0.3050 | 0.288000 | 0.102000 | 7.34e-03 | 3.44e-01 |
| Regulation of necroptotic cell death | 29 | 1.97e-02 | 4.64e-02 | 0.3050 | 0.288000 | 0.102000 | 7.34e-03 | 3.44e-01 |
| Hyaluronan uptake and degradation | 12 | 6.18e-05 | 2.86e-04 | 0.9000 | 0.537000 | 0.722000 | 1.29e-03 | 1.48e-05 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | 48 | 2.60e-10 | 3.62e-09 | 0.6630 | 0.552000 | 0.367000 | 3.56e-11 | 1.11e-05 |
| Metabolism of amino acids and derivatives | 323 | 1.32e-11 | 2.82e-10 | 0.1810 | 0.181000 | -0.004500 | 2.29e-08 | 8.89e-01 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 52 | 4.62e-10 | 6.00e-09 | 0.6250 | 0.524000 | 0.339000 | 5.98e-11 | 2.29e-05 |
| Regulation of lipid metabolism by PPARalpha | 106 | 4.43e-07 | 3.15e-06 | 0.3120 | 0.109000 | 0.293000 | 5.23e-02 | 1.91e-07 |
| Transcriptional regulation of white adipocyte differentiation | 77 | 2.08e-04 | 8.43e-04 | 0.2620 | 0.070500 | 0.252000 | 2.85e-01 | 1.30e-04 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | 55 | 6.02e-04 | 2.22e-03 | 0.3080 | 0.107000 | 0.289000 | 1.69e-01 | 2.10e-04 |
| Autodegradation of Cdh1 by Cdh1:APC/C | 64 | 8.68e-10 | 1.00e-08 | 0.5470 | 0.467000 | 0.286000 | 1.06e-10 | 7.53e-05 |
| Switching of origins to a post-replicative state | 89 | 2.22e-06 | 1.37e-05 | 0.3300 | 0.305000 | 0.126000 | 6.67e-07 | 4.06e-02 |
| Rev-mediated nuclear export of HIV RNA | 35 | 1.30e-02 | 3.37e-02 | 0.2910 | -0.096000 | -0.275000 | 3.26e-01 | 4.87e-03 |
| Ubiquitin-dependent degradation of Cyclin D | 50 | 4.17e-09 | 4.12e-08 | 0.6040 | 0.507000 | 0.328000 | 5.64e-10 | 5.93e-05 |
| Downstream TCR signaling | 100 | 7.56e-05 | 3.45e-04 | 0.2330 | 0.228000 | 0.049500 | 8.29e-05 | 3.92e-01 |
| Negative regulation of NOTCH4 signaling | 54 | 5.24e-10 | 6.61e-09 | 0.6130 | 0.513000 | 0.335000 | 6.95e-11 | 2.03e-05 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | 53 | 1.33e-10 | 2.07e-09 | 0.6410 | 0.533000 | 0.356000 | 1.85e-11 | 7.13e-06 |
| Collagen degradation | 28 | 3.93e-04 | 1.51e-03 | 0.5030 | 0.256000 | 0.432000 | 1.88e-02 | 7.48e-05 |
| Uptake and function of anthrax toxins | 10 | 5.79e-04 | 2.15e-03 | 0.8650 | 0.518000 | 0.693000 | 4.59e-03 | 1.47e-04 |
| Advanced glycosylation endproduct receptor signaling | 12 | 2.06e-04 | 8.37e-04 | 0.8410 | 0.501000 | 0.676000 | 2.65e-03 | 5.01e-05 |
| Inhibition of DNA recombination at telomere | 35 | 9.07e-04 | 3.20e-03 | 0.4100 | 0.189000 | 0.364000 | 5.29e-02 | 1.95e-04 |
| Regulation of ornithine decarboxylase (ODC) | 49 | 6.29e-11 | 1.09e-09 | 0.6830 | 0.562000 | 0.387000 | 9.77e-12 | 2.70e-06 |
| Interferon gamma signaling | 83 | 7.98e-04 | 2.86e-03 | 0.2190 | -0.043000 | -0.215000 | 4.98e-01 | 7.15e-04 |
| Clathrin-mediated endocytosis | 125 | 1.01e-10 | 1.61e-09 | 0.3920 | 0.179000 | 0.349000 | 5.66e-04 | 1.52e-11 |
| RHO GTPases Activate ROCKs | 18 | 2.84e-03 | 8.87e-03 | 0.5520 | 0.297000 | 0.466000 | 2.93e-02 | 6.26e-04 |
| Vif-mediated degradation of APOBEC3G | 52 | 4.96e-10 | 6.32e-09 | 0.6300 | 0.522000 | 0.353000 | 7.29e-11 | 1.05e-05 |
| APC/C:Cdc20 mediated degradation of Securin | 66 | 9.94e-10 | 1.13e-08 | 0.5420 | 0.458000 | 0.290000 | 1.26e-10 | 4.54e-05 |
| CDK-mediated phosphorylation and removal of Cdc6 | 71 | 5.59e-09 | 5.26e-08 | 0.4940 | 0.423000 | 0.256000 | 7.07e-10 | 1.93e-04 |
| Degradation of GLI2 by the proteasome | 56 | 2.30e-10 | 3.26e-09 | 0.6180 | 0.512000 | 0.346000 | 3.32e-11 | 7.62e-06 |
| GLI3 is processed to GLI3R by the proteasome | 56 | 2.30e-10 | 3.26e-09 | 0.6180 | 0.512000 | 0.346000 | 3.32e-11 | 7.62e-06 |
| Apoptotic factor-mediated response | 18 | 2.13e-03 | 6.85e-03 | 0.5690 | 0.476000 | 0.310000 | 4.66e-04 | 2.27e-02 |
| Rho GTPase cycle | 125 | 3.76e-04 | 1.45e-03 | 0.1640 | -0.000755 | 0.164000 | 9.88e-01 | 1.50e-03 |
| Cross-presentation of soluble exogenous antigens (endosomes) | 47 | 1.46e-10 | 2.23e-09 | 0.6880 | 0.562000 | 0.397000 | 2.57e-11 | 2.46e-06 |
| Stabilization of p53 | 54 | 5.25e-08 | 4.28e-07 | 0.5390 | 0.455000 | 0.290000 | 7.34e-09 | 2.26e-04 |
| Signaling by EGFR | 45 | 9.88e-04 | 3.42e-03 | 0.3520 | 0.153000 | 0.317000 | 7.52e-02 | 2.31e-04 |
| Platelet homeostasis | 67 | 7.04e-04 | 2.57e-03 | 0.2760 | 0.096400 | 0.259000 | 1.72e-01 | 2.45e-04 |
| Regulation of RUNX2 expression and activity | 66 | 3.52e-07 | 2.55e-06 | 0.4480 | 0.388000 | 0.225000 | 5.02e-08 | 1.55e-03 |
| trans-Golgi Network Vesicle Budding | 69 | 4.62e-09 | 4.46e-08 | 0.5080 | 0.269000 | 0.431000 | 1.13e-04 | 5.92e-10 |
| DARPP-32 events | 22 | 3.41e-03 | 1.04e-02 | 0.4860 | 0.253000 | 0.415000 | 3.97e-02 | 7.50e-04 |
| The NLRP3 inflammasome | 15 | 7.59e-04 | 2.74e-03 | 0.6870 | 0.560000 | 0.398000 | 1.75e-04 | 7.62e-03 |
| Signaling by ROBO receptors | 198 | 7.49e-06 | 4.11e-05 | 0.1590 | 0.159000 | -0.002830 | 1.17e-04 | 9.45e-01 |
| Degradation of GLI1 by the proteasome | 57 | 6.15e-10 | 7.63e-09 | 0.5990 | 0.496000 | 0.336000 | 9.16e-11 | 1.11e-05 |
| Glycosphingolipid metabolism | 36 | 2.09e-02 | 4.88e-02 | 0.2770 | 0.099200 | 0.259000 | 3.03e-01 | 7.22e-03 |
| Hh mutants abrogate ligand secretion | 54 | 1.81e-10 | 2.65e-09 | 0.6370 | 0.523000 | 0.363000 | 2.95e-11 | 3.84e-06 |
| Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD | 53 | 3.67e-11 | 6.67e-10 | 0.6680 | 0.545000 | 0.386000 | 6.52e-12 | 1.17e-06 |
| Degradation of AXIN | 53 | 7.74e-08 | 6.10e-07 | 0.5410 | 0.453000 | 0.294000 | 1.12e-08 | 2.09e-04 |
| Platelet activation, signaling and aggregation | 219 | 1.75e-18 | 1.03e-16 | 0.4050 | 0.196000 | 0.354000 | 5.63e-07 | 1.72e-19 |
| Mitotic G1 phase and G1/S transition | 148 | 4.73e-05 | 2.26e-04 | 0.1880 | 0.186000 | 0.028400 | 9.54e-05 | 5.51e-01 |
| VEGFA-VEGFR2 Pathway | 90 | 1.94e-05 | 9.96e-05 | 0.3040 | 0.121000 | 0.278000 | 4.65e-02 | 4.95e-06 |
| Assembly of the pre-replicative complex | 66 | 5.29e-06 | 3.04e-05 | 0.4000 | 0.350000 | 0.193000 | 8.60e-07 | 6.64e-03 |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | 17 | 1.91e-02 | 4.56e-02 | 0.4600 | 0.394000 | 0.237000 | 4.90e-03 | 9.05e-02 |
| PI Metabolism | 79 | 1.85e-02 | 4.51e-02 | 0.1320 | -0.028000 | 0.129000 | 6.67e-01 | 4.76e-02 |
| Nucleobase catabolism | 28 | 5.68e-03 | 1.63e-02 | 0.4010 | 0.351000 | 0.195000 | 1.32e-03 | 7.44e-02 |
| RHO GTPases Activate WASPs and WAVEs | 35 | 1.28e-08 | 1.14e-07 | 0.7200 | 0.425000 | 0.580000 | 1.32e-05 | 2.78e-09 |
| Circadian Clock | 67 | 1.87e-02 | 4.51e-02 | 0.1670 | 0.012300 | 0.167000 | 8.62e-01 | 1.82e-02 |
| Metabolism of RNA | 686 | 1.94e-14 | 6.96e-13 | 0.1260 | 0.122000 | -0.030900 | 5.16e-08 | 1.67e-01 |
| S Phase | 160 | 2.05e-04 | 8.36e-04 | 0.1490 | 0.149000 | -0.003830 | 1.14e-03 | 9.33e-01 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | 87 | 8.27e-12 | 1.85e-10 | 0.5280 | 0.442000 | 0.289000 | 1.03e-12 | 3.15e-06 |
| G1/S DNA Damage Checkpoints | 65 | 5.79e-07 | 4.02e-06 | 0.4490 | 0.384000 | 0.232000 | 8.35e-08 | 1.19e-03 |
| L1CAM interactions | 83 | 8.42e-06 | 4.57e-05 | 0.3420 | 0.154000 | 0.305000 | 1.52e-02 | 1.57e-06 |
| HDR through Homologous Recombination (HRR) | 66 | 9.87e-03 | 2.67e-02 | 0.2030 | -0.047800 | -0.198000 | 5.02e-01 | 5.47e-03 |
| Golgi Associated Vesicle Biogenesis | 55 | 4.29e-07 | 3.07e-06 | 0.5010 | 0.272000 | 0.421000 | 4.82e-04 | 6.46e-08 |
| Chemokine receptors bind chemokines | 39 | 2.01e-02 | 4.72e-02 | 0.2720 | -0.103000 | -0.252000 | 2.67e-01 | 6.52e-03 |
| Cargo recognition for clathrin-mediated endocytosis | 88 | 9.06e-07 | 6.09e-06 | 0.3690 | 0.175000 | 0.324000 | 4.43e-03 | 1.42e-07 |
| Spry regulation of FGF signaling | 16 | 8.44e-03 | 2.34e-02 | 0.5350 | 0.297000 | 0.444000 | 3.96e-02 | 2.08e-03 |
| Signaling by VEGF | 97 | 1.87e-04 | 7.64e-04 | 0.2500 | 0.087300 | 0.234000 | 1.37e-01 | 6.63e-05 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 72 | 1.71e-09 | 1.86e-08 | 0.5170 | 0.432000 | 0.285000 | 2.38e-10 | 2.83e-05 |
| Retrograde transport at the Trans-Golgi-Network | 49 | 5.65e-03 | 1.63e-02 | 0.2850 | 0.115000 | 0.261000 | 1.64e-01 | 1.59e-03 |
| COPII-mediated vesicle transport | 65 | 2.83e-09 | 2.88e-08 | 0.5400 | 0.302000 | 0.448000 | 2.50e-05 | 4.23e-10 |
| Unwinding of DNA | 12 | 4.92e-04 | 1.85e-03 | 0.8040 | -0.492000 | -0.635000 | 3.17e-03 | 1.38e-04 |
| Degradation of the extracellular matrix | 78 | 2.80e-04 | 1.11e-03 | 0.2860 | 0.118000 | 0.261000 | 7.11e-02 | 6.87e-05 |
| Hedgehog ligand biogenesis | 58 | 2.71e-10 | 3.71e-09 | 0.6130 | 0.498000 | 0.356000 | 5.09e-11 | 2.70e-06 |
| p53-Dependent G1 DNA Damage Response | 63 | 1.16e-06 | 7.65e-06 | 0.4490 | 0.381000 | 0.238000 | 1.74e-07 | 1.07e-03 |
| p53-Dependent G1/S DNA damage checkpoint | 63 | 1.16e-06 | 7.65e-06 | 0.4490 | 0.381000 | 0.238000 | 1.74e-07 | 1.07e-03 |
| Interleukin-12 signaling | 44 | 2.54e-04 | 1.01e-03 | 0.4130 | 0.354000 | 0.213000 | 4.72e-05 | 1.47e-02 |
| Interferon alpha/beta signaling | 57 | 5.28e-05 | 2.50e-04 | 0.3930 | -0.198000 | -0.340000 | 9.69e-03 | 9.10e-06 |
| Degradation of DVL | 54 | 5.38e-09 | 5.09e-08 | 0.5890 | 0.481000 | 0.340000 | 9.71e-10 | 1.53e-05 |
| SHC1 events in EGFR signaling | 11 | 1.95e-02 | 4.62e-02 | 0.5930 | 0.343000 | 0.484000 | 4.85e-02 | 5.45e-03 |
| PLC beta mediated events | 43 | 1.73e-02 | 4.33e-02 | 0.2680 | 0.107000 | 0.246000 | 2.26e-01 | 5.26e-03 |
| Glycosaminoglycan metabolism | 92 | 6.76e-03 | 1.91e-02 | 0.1720 | 0.030100 | 0.169000 | 6.18e-01 | 5.10e-03 |
| Transport to the Golgi and subsequent modification | 155 | 7.81e-14 | 2.53e-12 | 0.4240 | 0.223000 | 0.361000 | 1.74e-06 | 8.01e-15 |
| Signaling by TGF-beta Receptor Complex | 72 | 1.34e-02 | 3.46e-02 | 0.1890 | 0.044900 | 0.183000 | 5.10e-01 | 7.17e-03 |
| Oxidative Stress Induced Senescence | 79 | 1.79e-04 | 7.36e-04 | 0.2980 | 0.130000 | 0.268000 | 4.59e-02 | 3.88e-05 |
| Phosphorylation of CD3 and TCR zeta chains | 27 | 2.34e-07 | 1.73e-06 | 0.7580 | -0.463000 | -0.600000 | 3.13e-05 | 6.63e-08 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 36 | 8.04e-05 | 3.65e-04 | 0.5010 | 0.416000 | 0.279000 | 1.53e-05 | 3.75e-03 |
| activated TAK1 mediates p38 MAPK activation | 19 | 1.40e-03 | 4.72e-03 | 0.5840 | 0.338000 | 0.476000 | 1.07e-02 | 3.31e-04 |
| Leishmania infection | 243 | 2.10e-05 | 1.07e-04 | 0.1410 | 0.141000 | 0.003820 | 1.56e-04 | 9.18e-01 |
| Defective CFTR causes cystic fibrosis | 58 | 9.45e-11 | 1.53e-09 | 0.6300 | 0.509000 | 0.372000 | 2.04e-11 | 9.73e-07 |
| Membrane Trafficking | 555 | 5.19e-40 | 1.77e-37 | 0.3870 | 0.197000 | 0.333000 | 2.01e-15 | 3.07e-41 |
| Interferon Signaling | 177 | 2.10e-05 | 1.07e-04 | 0.1960 | -0.054700 | -0.189000 | 2.10e-01 | 1.48e-05 |
| Interleukin-12 family signaling | 53 | 1.30e-04 | 5.51e-04 | 0.3930 | 0.336000 | 0.205000 | 2.34e-05 | 9.85e-03 |
| Prefoldin mediated transfer of substrate to CCT/TriC | 26 | 1.82e-03 | 5.91e-03 | 0.4830 | 0.401000 | 0.270000 | 4.05e-04 | 1.71e-02 |
| Regulation of RUNX3 expression and activity | 55 | 2.11e-07 | 1.59e-06 | 0.5230 | 0.429000 | 0.299000 | 3.75e-08 | 1.26e-04 |
| Cargo concentration in the ER | 30 | 5.35e-07 | 3.74e-06 | 0.6990 | 0.425000 | 0.555000 | 5.63e-05 | 1.44e-07 |
| Formation of RNA Pol II elongation complex | 57 | 7.07e-03 | 1.97e-02 | 0.2620 | 0.111000 | 0.238000 | 1.48e-01 | 1.90e-03 |
| RNA Polymerase II Transcription Elongation | 57 | 7.07e-03 | 1.97e-02 | 0.2620 | 0.111000 | 0.238000 | 1.48e-01 | 1.90e-03 |
| Signaling by Rho GTPases | 364 | 1.72e-11 | 3.61e-10 | 0.2230 | 0.080900 | 0.208000 | 8.05e-03 | 9.52e-12 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | 25 | 6.91e-03 | 1.94e-02 | 0.4340 | 0.237000 | 0.364000 | 4.04e-02 | 1.65e-03 |
| Estrogen-dependent gene expression | 98 | 7.81e-04 | 2.82e-03 | 0.2330 | 0.089200 | 0.216000 | 1.27e-01 | 2.27e-04 |
| G-protein beta:gamma signalling | 29 | 1.95e-02 | 4.62e-02 | 0.3480 | 0.175000 | 0.301000 | 1.03e-01 | 5.01e-03 |
| ER-Phagosome pathway | 82 | 6.25e-12 | 1.44e-10 | 0.5590 | 0.453000 | 0.328000 | 1.28e-12 | 2.87e-07 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models | 20 | 8.61e-04 | 3.06e-03 | 0.5940 | 0.353000 | 0.478000 | 6.33e-03 | 2.15e-04 |
| Neurodegenerative Diseases | 20 | 8.61e-04 | 3.06e-03 | 0.5940 | 0.353000 | 0.478000 | 6.33e-03 | 2.15e-04 |
| Interleukin-4 and Interleukin-13 signaling | 92 | 4.35e-07 | 3.11e-06 | 0.3840 | 0.326000 | 0.203000 | 6.31e-08 | 7.44e-04 |
| Signaling by Non-Receptor Tyrosine Kinases | 47 | 3.38e-03 | 1.04e-02 | 0.3270 | 0.161000 | 0.284000 | 5.55e-02 | 7.49e-04 |
| Signaling by PTK6 | 47 | 3.38e-03 | 1.04e-02 | 0.3270 | 0.161000 | 0.284000 | 5.55e-02 | 7.49e-04 |
| MAP2K and MAPK activation | 34 | 2.70e-06 | 1.63e-05 | 0.6160 | 0.370000 | 0.493000 | 1.86e-04 | 6.56e-07 |
| Host Interactions of HIV factors | 129 | 6.55e-05 | 3.02e-04 | 0.2410 | 0.220000 | 0.097800 | 1.62e-05 | 5.52e-02 |
| Signaling by high-kinase activity BRAF mutants | 31 | 2.36e-05 | 1.18e-04 | 0.5870 | 0.349000 | 0.471000 | 7.60e-04 | 5.52e-06 |
| Negative regulation of MET activity | 18 | 1.23e-03 | 4.19e-03 | 0.6120 | 0.368000 | 0.489000 | 6.88e-03 | 3.24e-04 |
| ER to Golgi Anterograde Transport | 129 | 4.01e-16 | 1.88e-14 | 0.5220 | 0.304000 | 0.424000 | 2.52e-09 | 8.03e-17 |
| HuR (ELAVL1) binds and stabilizes mRNA | 10 | 5.50e-03 | 1.60e-02 | 0.7300 | 0.573000 | 0.452000 | 1.70e-03 | 1.32e-02 |
| TCR signaling | 121 | 1.97e-03 | 6.35e-03 | 0.1830 | 0.175000 | 0.054500 | 8.85e-04 | 3.00e-01 |
| CD28 dependent PI3K/Akt signaling | 22 | 5.42e-03 | 1.58e-02 | 0.4810 | -0.395000 | -0.275000 | 1.34e-03 | 2.55e-02 |
| Cellular Senescence | 144 | 5.04e-05 | 2.40e-04 | 0.2290 | 0.090500 | 0.210000 | 6.09e-02 | 1.33e-05 |
| Activation of NF-kappaB in B cells | 65 | 1.90e-08 | 1.62e-07 | 0.5210 | 0.423000 | 0.304000 | 3.71e-09 | 2.28e-05 |
| G2/M Checkpoints | 138 | 3.55e-04 | 1.38e-03 | 0.2030 | 0.189000 | 0.071600 | 1.21e-04 | 1.47e-01 |
| NS1 Mediated Effects on Host Pathways | 40 | 1.92e-02 | 4.58e-02 | 0.2920 | -0.139000 | -0.256000 | 1.27e-01 | 5.03e-03 |
| Cyclin E associated events during G1/S transition | 83 | 7.39e-06 | 4.08e-05 | 0.3630 | 0.308000 | 0.192000 | 1.18e-06 | 2.54e-03 |
| Regulation of PTEN gene transcription | 59 | 1.45e-02 | 3.73e-02 | 0.2380 | 0.101000 | 0.216000 | 1.81e-01 | 4.10e-03 |
| ATF6 (ATF6-alpha) activates chaperones | 12 | 2.09e-02 | 4.88e-02 | 0.5690 | 0.456000 | 0.341000 | 6.24e-03 | 4.10e-02 |
| Signaling by MET | 60 | 1.78e-05 | 9.24e-05 | 0.4180 | 0.233000 | 0.348000 | 1.84e-03 | 3.18e-06 |
| XBP1(S) activates chaperone genes | 47 | 4.51e-03 | 1.34e-02 | 0.3210 | 0.162000 | 0.277000 | 5.44e-02 | 1.01e-03 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | 73 | 1.33e-02 | 3.44e-02 | 0.2100 | 0.194000 | 0.080700 | 4.14e-03 | 2.33e-01 |
| Cyclin A:Cdk2-associated events at S phase entry | 85 | 3.17e-05 | 1.55e-04 | 0.3330 | 0.286000 | 0.172000 | 5.32e-06 | 6.07e-03 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) | 36 | 2.43e-04 | 9.64e-04 | 0.4770 | 0.276000 | 0.389000 | 4.18e-03 | 5.31e-05 |
| Signaling by WNT | 253 | 4.40e-09 | 4.32e-08 | 0.2510 | 0.112000 | 0.225000 | 2.23e-03 | 7.51e-10 |
| Hedgehog ‘on’ state | 74 | 2.24e-07 | 1.67e-06 | 0.4500 | 0.369000 | 0.256000 | 3.94e-08 | 1.36e-04 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | 179 | 1.84e-11 | 3.76e-10 | 0.3600 | 0.192000 | 0.304000 | 8.89e-06 | 2.15e-12 |
| Senescence-Associated Secretory Phenotype (SASP) | 66 | 5.90e-04 | 2.18e-03 | 0.3190 | 0.164000 | 0.274000 | 2.16e-02 | 1.15e-04 |
| RHO GTPase Effectors | 248 | 4.73e-10 | 6.08e-09 | 0.2740 | 0.131000 | 0.241000 | 3.86e-04 | 6.23e-11 |
| Apoptotic execution phase | 45 | 1.87e-02 | 4.51e-02 | 0.2770 | 0.134000 | 0.243000 | 1.20e-01 | 4.85e-03 |
| Sphingolipid metabolism | 78 | 3.46e-04 | 1.35e-03 | 0.3030 | 0.154000 | 0.261000 | 1.90e-02 | 6.55e-05 |
| Lysosome Vesicle Biogenesis | 32 | 5.17e-05 | 2.45e-04 | 0.5590 | 0.338000 | 0.445000 | 9.37e-04 | 1.33e-05 |
| Dissolution of Fibrin Clot | 12 | 1.32e-03 | 4.50e-03 | 0.7560 | 0.479000 | 0.585000 | 4.08e-03 | 4.47e-04 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 29 | 1.42e-03 | 4.79e-03 | 0.4740 | 0.384000 | 0.277000 | 3.46e-04 | 9.72e-03 |
| tRNA processing | 136 | 4.70e-03 | 1.39e-02 | 0.1600 | -0.046700 | -0.153000 | 3.47e-01 | 2.09e-03 |
| ABC transporter disorders | 69 | 3.39e-09 | 3.37e-08 | 0.5340 | 0.427000 | 0.321000 | 8.59e-10 | 4.05e-06 |
| IRE1alpha activates chaperones | 49 | 6.34e-03 | 1.80e-02 | 0.3060 | 0.157000 | 0.263000 | 5.77e-02 | 1.47e-03 |
| Amyloid fiber formation | 51 | 1.04e-05 | 5.58e-05 | 0.4730 | 0.277000 | 0.383000 | 6.15e-04 | 2.22e-06 |
| Transcriptional regulation by RUNX1 | 184 | 1.27e-04 | 5.41e-04 | 0.1890 | 0.070400 | 0.176000 | 9.97e-02 | 3.90e-05 |
| Signaling by Receptor Tyrosine Kinases | 408 | 6.64e-17 | 3.23e-15 | 0.2880 | 0.144000 | 0.249000 | 5.50e-07 | 6.16e-18 |
| COPI-mediated anterograde transport | 78 | 5.18e-11 | 9.29e-10 | 0.5550 | 0.338000 | 0.441000 | 2.53e-07 | 1.62e-11 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | 10 | 4.88e-03 | 1.44e-02 | 0.7430 | 0.471000 | 0.574000 | 9.91e-03 | 1.67e-03 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 51 | 8.74e-05 | 3.96e-04 | 0.4240 | 0.347000 | 0.244000 | 1.81e-05 | 2.59e-03 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 35 | 3.59e-03 | 1.09e-02 | 0.3950 | 0.223000 | 0.326000 | 2.24e-02 | 8.51e-04 |
| Fanconi Anemia Pathway | 36 | 2.72e-03 | 8.55e-03 | 0.4000 | -0.228000 | -0.329000 | 1.80e-02 | 6.41e-04 |
| MAPK6/MAPK4 signaling | 82 | 1.56e-07 | 1.19e-06 | 0.4350 | 0.354000 | 0.254000 | 3.07e-08 | 7.06e-05 |
| Downstream signaling events of B Cell Receptor (BCR) | 79 | 3.33e-07 | 2.43e-06 | 0.4320 | 0.351000 | 0.252000 | 6.58e-08 | 1.07e-04 |
| ESR-mediated signaling | 159 | 8.53e-06 | 4.61e-05 | 0.2540 | 0.124000 | 0.222000 | 7.19e-03 | 1.40e-06 |
| Calnexin/calreticulin cycle | 26 | 3.70e-03 | 1.12e-02 | 0.4640 | 0.276000 | 0.373000 | 1.49e-02 | 9.82e-04 |
| Antigen processing-Cross presentation | 97 | 1.34e-14 | 5.09e-13 | 0.5810 | 0.457000 | 0.360000 | 7.43e-15 | 9.10e-10 |
| Signaling by NOTCH4 | 78 | 6.11e-09 | 5.67e-08 | 0.4950 | 0.395000 | 0.299000 | 1.63e-09 | 4.90e-06 |
| Nuclear Events (kinase and transcription factor activation) | 53 | 2.26e-03 | 7.21e-03 | 0.3310 | 0.181000 | 0.276000 | 2.24e-02 | 4.98e-04 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | 48 | 1.03e-04 | 4.65e-04 | 0.4370 | 0.258000 | 0.352000 | 1.99e-03 | 2.38e-05 |
| Extracellular matrix organization | 215 | 2.23e-05 | 1.13e-04 | 0.2010 | 0.087500 | 0.181000 | 2.70e-02 | 4.61e-06 |
| Transcriptional regulation of granulopoiesis | 46 | 2.13e-04 | 8.57e-04 | 0.4280 | 0.253000 | 0.345000 | 2.96e-03 | 5.02e-05 |
| Response to elevated platelet cytosolic Ca2+ | 108 | 1.77e-15 | 7.55e-14 | 0.5690 | 0.353000 | 0.446000 | 2.17e-10 | 1.17e-15 |
| ABC-family proteins mediated transport | 92 | 4.57e-07 | 3.23e-06 | 0.3960 | 0.322000 | 0.230000 | 8.95e-08 | 1.33e-04 |
| Semaphorin interactions | 57 | 1.38e-02 | 3.55e-02 | 0.2600 | 0.132000 | 0.224000 | 8.37e-02 | 3.43e-03 |
| Asymmetric localization of PCP proteins | 60 | 7.60e-06 | 4.16e-05 | 0.4440 | 0.356000 | 0.265000 | 1.78e-06 | 3.83e-04 |
| Cytochrome c-mediated apoptotic response | 13 | 1.06e-02 | 2.86e-02 | 0.6000 | 0.467000 | 0.376000 | 3.52e-03 | 1.89e-02 |
| Opioid Signalling | 75 | 7.49e-04 | 2.72e-03 | 0.3010 | 0.162000 | 0.253000 | 1.50e-02 | 1.52e-04 |
| Protein localization | 157 | 1.36e-05 | 7.18e-05 | 0.2540 | 0.219000 | 0.129000 | 2.21e-06 | 5.18e-03 |
| Cristae formation | 31 | 1.07e-04 | 4.74e-04 | 0.5500 | 0.431000 | 0.342000 | 3.24e-05 | 9.91e-04 |
| SARS-CoV-2 Infection | 63 | 1.82e-03 | 5.91e-03 | 0.3090 | 0.169000 | 0.258000 | 2.03e-02 | 3.95e-04 |
| Metabolism of steroids | 116 | 7.26e-04 | 2.65e-03 | 0.2350 | 0.116000 | 0.204000 | 3.10e-02 | 1.45e-04 |
| Nucleotide salvage | 21 | 1.29e-02 | 3.36e-02 | 0.4580 | 0.365000 | 0.277000 | 3.81e-03 | 2.82e-02 |
| RHO GTPases Activate NADPH Oxidases | 21 | 4.40e-05 | 2.13e-04 | 0.7060 | 0.453000 | 0.541000 | 3.24e-04 | 1.78e-05 |
| Degradation of beta-catenin by the destruction complex | 83 | 7.78e-07 | 5.25e-06 | 0.4120 | 0.332000 | 0.245000 | 1.76e-07 | 1.12e-04 |
| Signaling by NOTCH1 | 66 | 3.25e-03 | 1.00e-02 | 0.2860 | 0.154000 | 0.241000 | 3.01e-02 | 7.25e-04 |
| Processing of Capped Intron-Containing Pre-mRNA | 238 | 2.56e-03 | 8.10e-03 | 0.1270 | 0.122000 | 0.035600 | 1.24e-03 | 3.44e-01 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 12 | 2.22e-06 | 1.37e-05 | 1.0700 | 0.713000 | 0.798000 | 1.90e-05 | 1.69e-06 |
| alpha-linolenic acid (ALA) metabolism | 12 | 2.22e-06 | 1.37e-05 | 1.0700 | 0.713000 | 0.798000 | 1.90e-05 | 1.69e-06 |
| CLEC7A (Dectin-1) signaling | 96 | 2.50e-10 | 3.51e-09 | 0.4850 | 0.383000 | 0.298000 | 8.76e-11 | 4.45e-07 |
| Intracellular signaling by second messengers | 271 | 1.90e-06 | 1.19e-05 | 0.2040 | 0.095800 | 0.181000 | 6.62e-03 | 3.13e-07 |
| NoRC negatively regulates rRNA expression | 59 | 2.08e-02 | 4.88e-02 | 0.2440 | 0.125000 | 0.209000 | 9.64e-02 | 5.39e-03 |
| Phase 0 - rapid depolarisation | 22 | 1.55e-02 | 3.94e-02 | 0.4380 | -0.348000 | -0.265000 | 4.66e-03 | 3.16e-02 |
| Plasma lipoprotein assembly, remodeling, and clearance | 52 | 8.22e-03 | 2.29e-02 | 0.2970 | 0.165000 | 0.247000 | 3.95e-02 | 2.02e-03 |
| ERK/MAPK targets | 22 | 1.17e-02 | 3.09e-02 | 0.4530 | 0.277000 | 0.359000 | 2.46e-02 | 3.55e-03 |
| Signaling by NOTCH | 182 | 1.21e-10 | 1.92e-09 | 0.3530 | 0.205000 | 0.287000 | 1.83e-06 | 2.25e-11 |
| ROS and RNS production in phagocytes | 31 | 4.57e-09 | 4.45e-08 | 0.8060 | 0.610000 | 0.528000 | 4.14e-09 | 3.65e-07 |
| Signaling by Nuclear Receptors | 214 | 7.27e-06 | 4.04e-05 | 0.2220 | 0.111000 | 0.193000 | 5.17e-03 | 1.16e-06 |
| RNA Polymerase II Pre-transcription Events | 78 | 5.95e-03 | 1.70e-02 | 0.2450 | 0.128000 | 0.210000 | 5.11e-02 | 1.37e-03 |
| Signaling by TGFB family members | 91 | 1.87e-02 | 4.51e-02 | 0.1920 | 0.089300 | 0.170000 | 1.41e-01 | 4.96e-03 |
| Transcriptional regulation by RUNX3 | 90 | 6.99e-05 | 3.20e-04 | 0.3230 | 0.265000 | 0.184000 | 1.41e-05 | 2.50e-03 |
| PIP3 activates AKT signaling | 239 | 3.01e-06 | 1.80e-05 | 0.2190 | 0.110000 | 0.189000 | 3.42e-03 | 4.62e-07 |
| Platelet degranulation | 104 | 5.72e-15 | 2.36e-13 | 0.5720 | 0.363000 | 0.442000 | 1.51e-10 | 6.13e-15 |
| TCF dependent signaling in response to WNT | 165 | 1.85e-05 | 9.58e-05 | 0.2480 | 0.131000 | 0.211000 | 3.56e-03 | 3.07e-06 |
| Cell Cycle Checkpoints | 258 | 3.20e-03 | 9.92e-03 | 0.1210 | 0.116000 | 0.036800 | 1.37e-03 | 3.09e-01 |
| Infectious disease | 773 | 8.59e-13 | 2.25e-11 | 0.1750 | 0.156000 | 0.078700 | 1.33e-13 | 1.97e-04 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 64 | 1.37e-09 | 1.53e-08 | 0.5760 | 0.444000 | 0.367000 | 8.09e-10 | 3.83e-07 |
| Smooth Muscle Contraction | 30 | 1.08e-05 | 5.75e-05 | 0.6310 | 0.406000 | 0.483000 | 1.18e-04 | 4.74e-06 |
| Costimulation by the CD28 family | 74 | 2.41e-04 | 9.61e-04 | 0.3350 | -0.196000 | -0.271000 | 3.52e-03 | 5.52e-05 |
| Respiratory electron transport | 101 | 1.86e-11 | 3.76e-10 | 0.5030 | 0.391000 | 0.317000 | 1.08e-11 | 3.80e-08 |
| G2/M Transition | 178 | 9.22e-04 | 3.24e-03 | 0.1840 | 0.162000 | 0.087600 | 1.92e-04 | 4.38e-02 |
| SARS-CoV Infections | 140 | 2.03e-04 | 8.29e-04 | 0.2390 | 0.128000 | 0.202000 | 9.11e-03 | 3.80e-05 |
| Integration of energy metabolism | 86 | 1.53e-04 | 6.38e-04 | 0.3180 | 0.185000 | 0.259000 | 3.05e-03 | 3.34e-05 |
| Oncogenic MAPK signaling | 73 | 2.88e-05 | 1.43e-04 | 0.3810 | 0.230000 | 0.304000 | 6.84e-04 | 7.29e-06 |
| p75 NTR receptor-mediated signalling | 88 | 1.23e-02 | 3.21e-02 | 0.2130 | 0.110000 | 0.183000 | 7.50e-02 | 3.01e-03 |
| C-type lectin receptors (CLRs) | 128 | 4.07e-10 | 5.34e-09 | 0.4160 | 0.328000 | 0.255000 | 1.41e-10 | 5.98e-07 |
| Neurotransmitter receptors and postsynaptic signal transmission | 123 | 6.53e-03 | 1.85e-02 | 0.1900 | 0.092700 | 0.165000 | 7.59e-02 | 1.53e-03 |
| Separation of Sister Chromatids | 167 | 1.07e-04 | 4.75e-04 | 0.2260 | 0.192000 | 0.119000 | 1.92e-05 | 7.95e-03 |
| Detoxification of Reactive Oxygen Species | 31 | 4.79e-09 | 4.60e-08 | 0.8070 | 0.605000 | 0.533000 | 5.35e-09 | 2.73e-07 |
| Energy dependent regulation of mTOR by LKB1-AMPK | 27 | 1.04e-03 | 3.58e-03 | 0.5130 | 0.326000 | 0.397000 | 3.41e-03 | 3.54e-04 |
| MHC class II antigen presentation | 101 | 9.23e-04 | 3.24e-03 | 0.2580 | 0.143000 | 0.214000 | 1.31e-02 | 1.96e-04 |
| Signal Transduction | 1869 | 7.70e-23 | 9.58e-21 | 0.1560 | 0.068400 | 0.140000 | 9.87e-07 | 1.51e-23 |
| RAB geranylgeranylation | 61 | 1.06e-05 | 5.66e-05 | 0.4390 | 0.273000 | 0.344000 | 2.25e-04 | 3.32e-06 |
| Disorders of transmembrane transporters | 144 | 2.81e-05 | 1.40e-04 | 0.2660 | 0.220000 | 0.149000 | 5.23e-06 | 2.02e-03 |
| Signaling by RAF1 mutants | 34 | 1.04e-04 | 4.67e-04 | 0.5300 | 0.339000 | 0.407000 | 6.23e-04 | 3.97e-05 |
| RNA polymerase II transcribes snRNA genes | 72 | 8.53e-03 | 2.35e-02 | 0.2530 | 0.142000 | 0.209000 | 3.76e-02 | 2.13e-03 |
| Signaling by NTRKs | 114 | 1.11e-08 | 1.01e-07 | 0.4060 | 0.252000 | 0.319000 | 3.49e-06 | 3.89e-09 |
| Mitotic G2-G2/M phases | 180 | 1.05e-03 | 3.59e-03 | 0.1850 | 0.160000 | 0.092900 | 2.12e-04 | 3.16e-02 |
| Transport of bile salts and organic acids, metal ions and amine compounds | 55 | 1.17e-02 | 3.09e-02 | 0.2820 | 0.163000 | 0.230000 | 3.60e-02 | 3.15e-03 |
| E3 ubiquitin ligases ubiquitinate target proteins | 52 | 1.57e-03 | 5.21e-03 | 0.3550 | 0.216000 | 0.282000 | 7.15e-03 | 4.36e-04 |
| MyD88 cascade initiated on plasma membrane | 82 | 1.81e-08 | 1.55e-07 | 0.4750 | 0.301000 | 0.367000 | 2.40e-06 | 8.68e-09 |
| Toll Like Receptor 10 (TLR10) Cascade | 82 | 1.81e-08 | 1.55e-07 | 0.4750 | 0.301000 | 0.367000 | 2.40e-06 | 8.68e-09 |
| Toll Like Receptor 5 (TLR5) Cascade | 82 | 1.81e-08 | 1.55e-07 | 0.4750 | 0.301000 | 0.367000 | 2.40e-06 | 8.68e-09 |
| Golgi-to-ER retrograde transport | 111 | 7.08e-10 | 8.39e-09 | 0.4430 | 0.279000 | 0.345000 | 3.89e-07 | 3.43e-10 |
| Apoptosis | 167 | 1.27e-11 | 2.75e-10 | 0.3930 | 0.309000 | 0.243000 | 5.41e-12 | 5.84e-08 |
| Phospholipid metabolism | 184 | 2.33e-04 | 9.30e-04 | 0.2060 | 0.109000 | 0.175000 | 1.05e-02 | 4.35e-05 |
| Programmed Cell Death | 179 | 4.51e-13 | 1.25e-11 | 0.4050 | 0.317000 | 0.252000 | 2.46e-13 | 5.87e-09 |
| Signaling by NTRK1 (TRKA) | 100 | 1.61e-07 | 1.22e-06 | 0.4010 | 0.249000 | 0.314000 | 1.62e-05 | 5.52e-08 |
| Factors involved in megakaryocyte development and platelet production | 116 | 1.22e-02 | 3.20e-02 | 0.1860 | 0.094800 | 0.160000 | 7.78e-02 | 2.98e-03 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 92 | 3.97e-12 | 9.49e-11 | 0.5470 | 0.353000 | 0.417000 | 4.95e-09 | 4.38e-12 |
| Toll Like Receptor 2 (TLR2) Cascade | 92 | 3.97e-12 | 9.49e-11 | 0.5470 | 0.353000 | 0.417000 | 4.95e-09 | 4.38e-12 |
| Toll Like Receptor TLR1:TLR2 Cascade | 92 | 3.97e-12 | 9.49e-11 | 0.5470 | 0.353000 | 0.417000 | 4.95e-09 | 4.38e-12 |
| Toll Like Receptor TLR6:TLR2 Cascade | 92 | 3.97e-12 | 9.49e-11 | 0.5470 | 0.353000 | 0.417000 | 4.95e-09 | 4.38e-12 |
| Diseases associated with O-glycosylation of proteins | 47 | 1.11e-02 | 2.95e-02 | 0.3100 | -0.249000 | -0.184000 | 3.13e-03 | 2.87e-02 |
| Metabolism of lipids | 619 | 8.44e-15 | 3.38e-13 | 0.2260 | 0.124000 | 0.189000 | 1.28e-07 | 9.92e-16 |
| Interleukin-17 signaling | 68 | 5.99e-06 | 3.41e-05 | 0.4270 | 0.268000 | 0.333000 | 1.29e-04 | 2.09e-06 |
| MAP kinase activation | 63 | 5.52e-06 | 3.16e-05 | 0.4460 | 0.282000 | 0.346000 | 1.09e-04 | 2.03e-06 |
| Transcriptional regulation by RUNX2 | 99 | 2.91e-05 | 1.44e-04 | 0.3270 | 0.261000 | 0.197000 | 7.28e-06 | 7.17e-04 |
| mRNA Splicing | 187 | 2.22e-03 | 7.12e-03 | 0.1700 | 0.148000 | 0.084100 | 4.77e-04 | 4.75e-02 |
| Ion channel transport | 133 | 3.91e-03 | 1.18e-02 | 0.1960 | 0.103000 | 0.167000 | 3.97e-02 | 8.72e-04 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 124 | 3.60e-13 | 1.02e-11 | 0.4910 | 0.378000 | 0.314000 | 3.72e-13 | 1.50e-09 |
| mRNA Splicing - Major Pathway | 179 | 3.91e-03 | 1.18e-02 | 0.1650 | 0.144000 | 0.080900 | 8.79e-04 | 6.20e-02 |
| Sphingolipid de novo biosynthesis | 42 | 1.09e-02 | 2.90e-02 | 0.3300 | 0.200000 | 0.263000 | 2.51e-02 | 3.20e-03 |
| LDL clearance | 17 | 1.87e-02 | 4.51e-02 | 0.4930 | 0.316000 | 0.379000 | 2.40e-02 | 6.82e-03 |
| Signaling by BRAF and RAF fusions | 57 | 1.35e-05 | 7.15e-05 | 0.4520 | 0.287000 | 0.349000 | 1.81e-04 | 5.08e-06 |
| IRAK4 deficiency (TLR2/4) | 10 | 1.45e-06 | 9.18e-06 | 1.1900 | 0.813000 | 0.875000 | 8.51e-06 | 1.65e-06 |
| MyD88 deficiency (TLR2/4) | 10 | 1.45e-06 | 9.18e-06 | 1.1900 | 0.813000 | 0.875000 | 8.51e-06 | 1.65e-06 |
| IKK complex recruitment mediated by RIP1 | 23 | 5.00e-03 | 1.47e-02 | 0.4900 | 0.376000 | 0.314000 | 1.81e-03 | 9.07e-03 |
| Interleukin-1 signaling | 97 | 4.68e-16 | 2.13e-14 | 0.6190 | 0.467000 | 0.406000 | 1.77e-15 | 4.61e-12 |
| The citric acid (TCA) cycle and respiratory electron transport | 172 | 1.46e-15 | 6.41e-14 | 0.4560 | 0.351000 | 0.290000 | 1.93e-15 | 4.96e-11 |
| Amino acids regulate mTORC1 | 50 | 2.33e-04 | 9.30e-04 | 0.4160 | 0.263000 | 0.323000 | 1.31e-03 | 7.82e-05 |
| Post-translational protein phosphorylation | 68 | 1.23e-06 | 8.01e-06 | 0.4570 | 0.292000 | 0.351000 | 3.15e-05 | 5.45e-07 |
| Regulation of RAS by GAPs | 66 | 2.31e-05 | 1.16e-04 | 0.4090 | 0.318000 | 0.258000 | 8.12e-06 | 2.83e-04 |
| Asparagine N-linked glycosylation | 269 | 1.43e-17 | 7.80e-16 | 0.3870 | 0.243000 | 0.302000 | 7.07e-12 | 1.48e-17 |
| HIV Infection | 224 | 6.15e-08 | 4.93e-07 | 0.2740 | 0.220000 | 0.162000 | 1.38e-08 | 2.80e-05 |
| MTOR signalling | 39 | 1.10e-04 | 4.83e-04 | 0.4950 | 0.320000 | 0.377000 | 5.37e-04 | 4.62e-05 |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | 27 | 7.05e-03 | 1.97e-02 | 0.4370 | 0.280000 | 0.335000 | 1.17e-02 | 2.55e-03 |
| Pyruvate metabolism | 28 | 5.65e-03 | 1.63e-02 | 0.4390 | 0.337000 | 0.282000 | 2.05e-03 | 9.85e-03 |
| Mitotic Metaphase and Anaphase | 224 | 2.43e-05 | 1.21e-04 | 0.2160 | 0.177000 | 0.123000 | 4.70e-06 | 1.52e-03 |
| Diseases of signal transduction by growth factor receptors and second messengers | 339 | 1.99e-11 | 3.94e-10 | 0.2720 | 0.163000 | 0.218000 | 2.35e-07 | 5.31e-12 |
| Cellular responses to stress | 497 | 3.13e-13 | 9.09e-12 | 0.2420 | 0.196000 | 0.142000 | 6.60e-14 | 5.74e-08 |
| Cellular responses to external stimuli | 503 | 1.05e-13 | 3.19e-12 | 0.2460 | 0.198000 | 0.146000 | 2.49e-14 | 2.30e-08 |
| Protein ubiquitination | 72 | 3.73e-05 | 1.82e-04 | 0.3840 | 0.244000 | 0.296000 | 3.44e-04 | 1.38e-05 |
| Innate Immune System | 963 | 8.82e-86 | 6.01e-83 | 0.4700 | 0.357000 | 0.306000 | 4.15e-79 | 2.68e-58 |
| Regulation of TLR by endogenous ligand | 11 | 4.26e-06 | 2.48e-05 | 1.0900 | 0.798000 | 0.746000 | 4.59e-06 | 1.81e-05 |
| MAPK targets/ Nuclear events mediated by MAP kinases | 31 | 8.38e-03 | 2.33e-02 | 0.4010 | 0.257000 | 0.308000 | 1.34e-02 | 3.01e-03 |
| Mitotic Anaphase | 223 | 2.11e-05 | 1.08e-04 | 0.2190 | 0.178000 | 0.128000 | 4.43e-06 | 1.01e-03 |
| Hedgehog ‘off’ state | 91 | 1.16e-04 | 4.99e-04 | 0.3210 | 0.250000 | 0.200000 | 3.63e-05 | 9.72e-04 |
| PTEN Regulation | 138 | 1.41e-06 | 9.04e-06 | 0.3180 | 0.198000 | 0.248000 | 5.90e-05 | 4.75e-07 |
| Cell Cycle | 622 | 1.57e-02 | 3.97e-02 | 0.0613 | 0.060300 | 0.011200 | 1.03e-02 | 6.32e-01 |
| Pentose phosphate pathway | 13 | 5.13e-03 | 1.50e-02 | 0.6550 | 0.438000 | 0.487000 | 6.22e-03 | 2.38e-03 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 78 | 4.80e-06 | 2.77e-05 | 0.4050 | 0.262000 | 0.310000 | 6.46e-05 | 2.25e-06 |
| Toll Like Receptor 9 (TLR9) Cascade | 92 | 5.87e-09 | 5.48e-08 | 0.4660 | 0.305000 | 0.352000 | 4.10e-07 | 5.42e-09 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 52 | 6.38e-04 | 2.34e-03 | 0.3850 | 0.294000 | 0.248000 | 2.46e-04 | 1.96e-03 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 87 | 1.61e-09 | 1.77e-08 | 0.4960 | 0.327000 | 0.373000 | 1.35e-07 | 1.88e-09 |
| Cytokine Signaling in Immune system | 733 | 1.39e-07 | 1.07e-06 | 0.1440 | 0.122000 | 0.076400 | 1.95e-08 | 4.32e-04 |
| p130Cas linkage to MAPK signaling for integrins | 11 | 8.77e-04 | 3.11e-03 | 0.8240 | 0.560000 | 0.605000 | 1.31e-03 | 5.14e-04 |
| Metabolism of carbohydrates | 241 | 6.81e-05 | 3.13e-04 | 0.2000 | 0.117000 | 0.162000 | 1.80e-03 | 1.49e-05 |
| Vesicle-mediated transport | 644 | 5.08e-27 | 8.66e-25 | 0.3160 | 0.200000 | 0.245000 | 4.78e-18 | 2.49e-26 |
| Toll Like Receptor 4 (TLR4) Cascade | 121 | 7.69e-13 | 2.05e-11 | 0.4940 | 0.326000 | 0.371000 | 5.97e-10 | 1.80e-12 |
| Cell Cycle, Mitotic | 500 | 1.33e-02 | 3.44e-02 | 0.0805 | 0.074600 | 0.030200 | 4.27e-03 | 2.48e-01 |
| Growth hormone receptor signaling | 20 | 1.10e-02 | 2.94e-02 | 0.4870 | 0.366000 | 0.322000 | 4.61e-03 | 1.27e-02 |
| Regulation of PTEN stability and activity | 66 | 2.68e-08 | 2.24e-07 | 0.5280 | 0.395000 | 0.351000 | 2.84e-08 | 8.12e-07 |
| Signaling by SCF-KIT | 40 | 8.51e-03 | 2.34e-02 | 0.3530 | 0.270000 | 0.227000 | 3.11e-03 | 1.31e-02 |
| MyD88 dependent cascade initiated on endosome | 88 | 5.14e-09 | 4.90e-08 | 0.4790 | 0.316000 | 0.359000 | 2.96e-07 | 5.59e-09 |
| Beta-catenin independent WNT signaling | 136 | 3.30e-06 | 1.96e-05 | 0.3110 | 0.197000 | 0.240000 | 7.20e-05 | 1.29e-06 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 36 | 1.22e-02 | 3.20e-02 | 0.3580 | 0.274000 | 0.230000 | 4.51e-03 | 1.68e-02 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | 89 | 1.82e-09 | 1.96e-08 | 0.4890 | 0.324000 | 0.366000 | 1.30e-07 | 2.29e-09 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 30 | 1.35e-04 | 5.70e-04 | 0.5610 | 0.416000 | 0.375000 | 7.86e-05 | 3.74e-04 |
| Post-translational protein modification | 1183 | 1.18e-21 | 1.15e-19 | 0.2080 | 0.126000 | 0.166000 | 2.77e-13 | 6.39e-22 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | 12 | 1.49e-02 | 3.81e-02 | 0.6090 | 0.450000 | 0.410000 | 6.95e-03 | 1.38e-02 |
| Protein folding | 90 | 1.90e-03 | 6.14e-03 | 0.2690 | 0.169000 | 0.209000 | 5.54e-03 | 6.22e-04 |
| HIV Life Cycle | 144 | 1.76e-02 | 4.38e-02 | 0.1670 | 0.136000 | 0.097200 | 4.92e-03 | 4.41e-02 |
| Signaling by Interleukins | 385 | 3.30e-21 | 3.00e-19 | 0.3610 | 0.274000 | 0.235000 | 2.66e-20 | 2.17e-15 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | 38 | 1.15e-04 | 4.96e-04 | 0.5030 | 0.337000 | 0.373000 | 3.30e-04 | 6.79e-05 |
| Signaling by RAS mutants | 38 | 1.15e-04 | 4.96e-04 | 0.5030 | 0.337000 | 0.373000 | 3.30e-04 | 6.79e-05 |
| Signaling by moderate kinase activity BRAF mutants | 38 | 1.15e-04 | 4.96e-04 | 0.5030 | 0.337000 | 0.373000 | 3.30e-04 | 6.79e-05 |
| Signaling downstream of RAS mutants | 38 | 1.15e-04 | 4.96e-04 | 0.5030 | 0.337000 | 0.373000 | 3.30e-04 | 6.79e-05 |
| HIV Transcription Initiation | 45 | 1.89e-02 | 4.51e-02 | 0.3040 | 0.196000 | 0.232000 | 2.31e-02 | 7.04e-03 |
| RNA Polymerase II HIV Promoter Escape | 45 | 1.89e-02 | 4.51e-02 | 0.3040 | 0.196000 | 0.232000 | 2.31e-02 | 7.04e-03 |
| RNA Polymerase II Promoter Escape | 45 | 1.89e-02 | 4.51e-02 | 0.3040 | 0.196000 | 0.232000 | 2.31e-02 | 7.04e-03 |
| RNA Polymerase II Transcription Initiation | 45 | 1.89e-02 | 4.51e-02 | 0.3040 | 0.196000 | 0.232000 | 2.31e-02 | 7.04e-03 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | 45 | 1.89e-02 | 4.51e-02 | 0.3040 | 0.196000 | 0.232000 | 2.31e-02 | 7.04e-03 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 45 | 1.89e-02 | 4.51e-02 | 0.3040 | 0.196000 | 0.232000 | 2.31e-02 | 7.04e-03 |
| Iron uptake and transport | 52 | 1.86e-06 | 1.17e-05 | 0.5190 | 0.384000 | 0.348000 | 1.62e-06 | 1.41e-05 |
| Neddylation | 217 | 1.43e-05 | 7.51e-05 | 0.2310 | 0.144000 | 0.180000 | 2.52e-04 | 4.64e-06 |
| Axon guidance | 451 | 6.55e-07 | 4.53e-06 | 0.1800 | 0.144000 | 0.109000 | 1.68e-07 | 7.16e-05 |
| InlB-mediated entry of Listeria monocytogenes into host cell | 12 | 1.65e-02 | 4.16e-02 | 0.6020 | 0.409000 | 0.442000 | 1.42e-02 | 7.99e-03 |
| Signaling by Hedgehog | 119 | 2.16e-05 | 1.10e-04 | 0.3080 | 0.234000 | 0.201000 | 1.07e-05 | 1.48e-04 |
| EPH-Ephrin signaling | 78 | 3.12e-08 | 2.58e-07 | 0.4850 | 0.327000 | 0.359000 | 6.11e-07 | 4.35e-08 |
| Toll-like Receptor Cascades | 143 | 3.96e-14 | 1.32e-12 | 0.4790 | 0.322000 | 0.354000 | 2.73e-11 | 2.48e-13 |
| Chaperonin-mediated protein folding | 84 | 1.54e-03 | 5.14e-03 | 0.2850 | 0.186000 | 0.216000 | 3.20e-03 | 6.34e-04 |
| Formation of ATP by chemiosmotic coupling | 18 | 3.96e-04 | 1.52e-03 | 0.6800 | 0.466000 | 0.495000 | 6.13e-04 | 2.76e-04 |
| Transferrin endocytosis and recycling | 26 | 6.00e-06 | 3.41e-05 | 0.7010 | 0.481000 | 0.510000 | 2.15e-05 | 6.73e-06 |
| EPHB-mediated forward signaling | 32 | 1.00e-06 | 6.70e-06 | 0.6780 | 0.493000 | 0.465000 | 1.40e-06 | 5.27e-06 |
| Nervous system development | 470 | 2.58e-06 | 1.57e-05 | 0.1690 | 0.133000 | 0.105000 | 8.19e-07 | 9.50e-05 |
| Ub-specific processing proteases | 169 | 2.78e-06 | 1.67e-05 | 0.2830 | 0.213000 | 0.186000 | 1.70e-06 | 3.02e-05 |
| Cellular response to hypoxia | 71 | 5.74e-10 | 7.17e-09 | 0.5650 | 0.412000 | 0.386000 | 1.84e-09 | 1.87e-08 |
| Adaptive Immune System | 753 | 2.04e-02 | 4.78e-02 | 0.0683 | 0.059700 | 0.033300 | 5.32e-03 | 1.20e-01 |
| Diseases of carbohydrate metabolism | 29 | 1.70e-02 | 4.25e-02 | 0.3860 | 0.260000 | 0.286000 | 1.55e-02 | 7.78e-03 |
| PCP/CE pathway | 86 | 3.06e-07 | 2.24e-06 | 0.4310 | 0.292000 | 0.317000 | 2.94e-06 | 3.74e-07 |
| Developmental Biology | 726 | 1.49e-07 | 1.14e-06 | 0.1510 | 0.093700 | 0.119000 | 1.73e-05 | 4.86e-08 |
| FLT3 Signaling | 242 | 6.00e-05 | 2.81e-04 | 0.2060 | 0.132000 | 0.157000 | 3.90e-04 | 2.44e-05 |
| Metabolism | 1758 | 1.93e-34 | 5.26e-32 | 0.2240 | 0.170000 | 0.145000 | 1.72e-32 | 4.24e-24 |
| Immune System | 1885 | 3.55e-42 | 1.61e-39 | 0.2410 | 0.182000 | 0.158000 | 3.38e-39 | 8.29e-30 |
| Regulation of insulin secretion | 60 | 1.13e-02 | 2.98e-02 | 0.2810 | 0.186000 | 0.210000 | 1.26e-02 | 4.81e-03 |
| Disease | 1339 | 2.57e-14 | 8.76e-13 | 0.1600 | 0.125000 | 0.101000 | 1.99e-14 | 6.27e-10 |
| Activation of Matrix Metalloproteinases | 23 | 1.56e-02 | 3.95e-02 | 0.4380 | 0.298000 | 0.321000 | 1.34e-02 | 7.61e-03 |
| Metabolism of proteins | 1706 | 2.40e-31 | 5.44e-29 | 0.2160 | 0.164000 | 0.141000 | 1.35e-29 | 3.77e-22 |
| Late endosomal microautophagy | 29 | 1.52e-04 | 6.38e-04 | 0.5680 | 0.413000 | 0.390000 | 1.18e-04 | 2.81e-04 |
| Antigen processing: Ubiquitination & Proteasome degradation | 286 | 7.83e-04 | 2.82e-03 | 0.1620 | 0.102000 | 0.126000 | 2.98e-03 | 2.60e-04 |
| Signaling by Insulin receptor | 59 | 1.38e-04 | 5.83e-04 | 0.4000 | 0.271000 | 0.294000 | 3.14e-04 | 9.30e-05 |
| MyD88-independent TLR4 cascade | 96 | 5.83e-08 | 4.70e-07 | 0.4300 | 0.292000 | 0.315000 | 7.40e-07 | 9.40e-08 |
| TRIF(TICAM1)-mediated TLR4 signaling | 96 | 5.83e-08 | 4.70e-07 | 0.4300 | 0.292000 | 0.315000 | 7.40e-07 | 9.40e-08 |
| Interleukin-1 family signaling | 124 | 5.86e-13 | 1.60e-11 | 0.4920 | 0.359000 | 0.336000 | 4.74e-12 | 9.59e-11 |
| Budding and maturation of HIV virion | 26 | 7.33e-06 | 4.06e-05 | 0.6960 | 0.480000 | 0.503000 | 2.23e-05 | 8.90e-06 |
| Deubiquitination | 240 | 1.26e-06 | 8.19e-06 | 0.2450 | 0.162000 | 0.184000 | 1.60e-05 | 8.53e-07 |
| Selective autophagy | 57 | 1.04e-03 | 3.58e-03 | 0.3580 | 0.264000 | 0.241000 | 5.67e-04 | 1.63e-03 |
| Signal amplification | 28 | 1.87e-03 | 6.05e-03 | 0.4880 | 0.334000 | 0.356000 | 2.22e-03 | 1.10e-03 |
| Toll Like Receptor 3 (TLR3) Cascade | 92 | 6.90e-06 | 3.89e-05 | 0.3710 | 0.251000 | 0.273000 | 3.11e-05 | 6.18e-06 |
| Golgi Cisternae Pericentriolar Stack Reorganization | 14 | 6.29e-04 | 2.32e-03 | 0.7490 | 0.519000 | 0.540000 | 7.78e-04 | 4.69e-04 |
| Class I MHC mediated antigen processing & presentation | 347 | 1.92e-08 | 1.63e-07 | 0.2340 | 0.155000 | 0.175000 | 6.89e-07 | 1.99e-08 |
| Diseases associated with the TLR signaling cascade | 23 | 6.14e-05 | 2.85e-04 | 0.6700 | 0.484000 | 0.464000 | 5.95e-05 | 1.18e-04 |
| Diseases of Immune System | 23 | 6.14e-05 | 2.85e-04 | 0.6700 | 0.484000 | 0.464000 | 5.95e-05 | 1.18e-04 |
| M Phase | 359 | 1.68e-04 | 6.97e-04 | 0.1600 | 0.123000 | 0.103000 | 6.58e-05 | 7.98e-04 |
| Gene expression (Transcription) | 1325 | 3.24e-03 | 1.00e-02 | 0.0660 | -0.036000 | -0.055300 | 2.78e-02 | 7.28e-04 |
| UCH proteinases | 86 | 1.71e-04 | 7.08e-04 | 0.3280 | 0.222000 | 0.241000 | 3.70e-04 | 1.13e-04 |
| ADP signalling through P2Y purinoceptor 1 | 21 | 1.75e-02 | 4.38e-02 | 0.4530 | 0.329000 | 0.311000 | 9.04e-03 | 1.37e-02 |
| Infection with Mycobacterium tuberculosis | 26 | 9.89e-04 | 3.42e-03 | 0.5320 | 0.385000 | 0.367000 | 6.72e-04 | 1.19e-03 |
| MAPK family signaling cascades | 267 | 1.71e-05 | 8.96e-05 | 0.2090 | 0.139000 | 0.157000 | 9.23e-05 | 1.05e-05 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 15 | 1.44e-02 | 3.69e-02 | 0.5490 | 0.397000 | 0.379000 | 7.83e-03 | 1.10e-02 |
| Macroautophagy | 109 | 1.67e-07 | 1.27e-06 | 0.3910 | 0.268000 | 0.285000 | 1.36e-06 | 2.80e-07 |
| Transport of small molecules | 554 | 2.73e-13 | 8.08e-12 | 0.2380 | 0.160000 | 0.176000 | 1.31e-10 | 1.22e-12 |
| Signaling by Leptin | 10 | 6.91e-03 | 1.94e-02 | 0.7280 | 0.523000 | 0.507000 | 4.21e-03 | 5.54e-03 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | 12 | 1.70e-03 | 5.57e-03 | 0.7520 | 0.540000 | 0.524000 | 1.20e-03 | 1.67e-03 |
| RAF/MAP kinase cascade | 228 | 1.27e-04 | 5.41e-04 | 0.2050 | 0.137000 | 0.153000 | 3.79e-04 | 7.13e-05 |
| Regulation of IFNG signaling | 14 | 1.23e-02 | 3.22e-02 | 0.5780 | 0.401000 | 0.417000 | 9.41e-03 | 6.92e-03 |
| RAF activation | 32 | 4.58e-03 | 1.36e-02 | 0.4230 | 0.291000 | 0.307000 | 4.36e-03 | 2.63e-03 |
| Complex I biogenesis | 55 | 1.04e-05 | 5.58e-05 | 0.4720 | 0.341000 | 0.325000 | 1.19e-05 | 2.98e-05 |
| mTORC1-mediated signalling | 24 | 3.24e-04 | 1.27e-03 | 0.5970 | 0.430000 | 0.414000 | 2.67e-04 | 4.40e-04 |
| Hemostasis | 542 | 1.02e-13 | 3.17e-12 | 0.2450 | 0.166000 | 0.180000 | 4.31e-11 | 6.88e-13 |
| Transmission across Chemical Synapses | 170 | 1.69e-02 | 4.23e-02 | 0.1600 | 0.105000 | 0.120000 | 1.79e-02 | 6.97e-03 |
| Fatty acid metabolism | 150 | 5.50e-04 | 2.06e-03 | 0.2310 | 0.170000 | 0.156000 | 3.20e-04 | 9.61e-04 |
| Erythrocytes take up carbon dioxide and release oxygen | 11 | 1.14e-04 | 4.96e-04 | 0.9380 | 0.670000 | 0.656000 | 1.19e-04 | 1.64e-04 |
| O2/CO2 exchange in erythrocytes | 11 | 1.14e-04 | 4.96e-04 | 0.9380 | 0.670000 | 0.656000 | 1.19e-04 | 1.64e-04 |
| Late Phase of HIV Life Cycle | 131 | 1.85e-02 | 4.51e-02 | 0.1800 | 0.134000 | 0.120000 | 8.17e-03 | 1.75e-02 |
| MAPK1/MAPK3 signaling | 233 | 3.13e-05 | 1.54e-04 | 0.2180 | 0.148000 | 0.161000 | 1.03e-04 | 2.35e-05 |
| Citric acid cycle (TCA cycle) | 22 | 1.46e-02 | 3.73e-02 | 0.4520 | 0.314000 | 0.326000 | 1.08e-02 | 8.14e-03 |
| COPI-dependent Golgi-to-ER retrograde traffic | 78 | 4.59e-04 | 1.74e-03 | 0.3240 | 0.224000 | 0.235000 | 6.32e-04 | 3.39e-04 |
| Signaling by ERBB4 | 44 | 1.98e-02 | 4.67e-02 | 0.3080 | 0.213000 | 0.223000 | 1.45e-02 | 1.06e-02 |
| Generic Transcription Pathway | 1078 | 7.38e-04 | 2.68e-03 | 0.0858 | -0.055800 | -0.065300 | 2.00e-03 | 2.98e-04 |
| Insulin receptor recycling | 21 | 3.68e-06 | 2.16e-05 | 0.7970 | 0.568000 | 0.559000 | 6.62e-06 | 9.21e-06 |
| Signalling to ERKs | 31 | 2.07e-03 | 6.66e-03 | 0.4610 | 0.322000 | 0.330000 | 1.92e-03 | 1.47e-03 |
| Glycerophospholipid biosynthesis | 106 | 1.72e-04 | 7.10e-04 | 0.2960 | 0.213000 | 0.205000 | 1.50e-04 | 2.67e-04 |
| Autophagy | 123 | 2.74e-10 | 3.71e-09 | 0.4380 | 0.306000 | 0.313000 | 4.39e-09 | 2.09e-09 |
| TP53 Regulates Metabolic Genes | 85 | 3.89e-05 | 1.89e-04 | 0.3570 | 0.255000 | 0.250000 | 4.67e-05 | 6.84e-05 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | 29 | 2.53e-06 | 1.56e-05 | 0.6880 | 0.489000 | 0.484000 | 5.07e-06 | 6.42e-06 |
| Gluconeogenesis | 28 | 5.97e-03 | 1.71e-02 | 0.4420 | 0.315000 | 0.310000 | 3.93e-03 | 4.57e-03 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | 82 | 2.77e-09 | 2.85e-08 | 0.5070 | 0.361000 | 0.356000 | 1.63e-08 | 2.51e-08 |
| Mitochondrial biogenesis | 88 | 3.60e-04 | 1.39e-03 | 0.3100 | 0.221000 | 0.217000 | 3.29e-04 | 4.22e-04 |
| Neutrophil degranulation | 456 | 5.75e-107 | 7.84e-104 | 0.7600 | 0.536000 | 0.539000 | 3.01e-86 | 2.42e-87 |
| Response of Mtb to phagocytosis | 22 | 2.58e-03 | 8.15e-03 | 0.5370 | 0.378000 | 0.382000 | 2.12e-03 | 1.94e-03 |
| Unfolded Protein Response (UPR) | 87 | 1.35e-02 | 3.47e-02 | 0.2300 | 0.164000 | 0.161000 | 8.20e-03 | 9.27e-03 |
Detailed Gene set reports
Scavenging of heme from plasma
| metric | value |
|---|---|
| setSize | 70 |
| pMANOVA | 3.83e-27 |
| p.adjustMANOVA | 7.46e-25 |
| s.dist | 0.513 |
| s.low.CRP | 0.192 |
| s.high.CRP | -0.476 |
| p.low.CRP | 0.00538 |
| p.high.CRP | 5.82e-12 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGHA1 | 6020 | -8527 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| JCHAIN | 5415 | -8049 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ALB | 5157 | 1598 |
| APOL1 | 1106 | -9021 |
| CD163 | 10141 | 10559 |
| HBA1 | 9695 | 8704 |
| HBB | 9671 | 6093 |
| HP | 10242 | 10523 |
| HPX | 2028 | -3809 |
| IGHA1 | 6020 | -8527 |
| IGHA2 | 3566 | -2966 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| JCHAIN | 5415 | -8049 |
| LRP1 | 8118 | 10314 |
Classical antibody-mediated complement activation
| metric | value |
|---|---|
| setSize | 68 |
| pMANOVA | 3.04e-23 |
| p.adjustMANOVA | 4.6e-21 |
| s.dist | 0.517 |
| s.low.CRP | 0.0986 |
| s.high.CRP | -0.507 |
| p.low.CRP | 0.16 |
| p.high.CRP | 4.48e-13 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
| IGLV1-44 | 3169 | -7580 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| C1QA | 2730 | 7449 |
| C1QB | 7676 | 9366 |
| C1QC | 8977 | 9784 |
| C1R | -9046 | -4725 |
| C1S | -1133 | 4982 |
| IGHG1 | -3727 | -9610 |
| IGHG2 | -2988 | -6697 |
| IGHG3 | 3688 | -4504 |
| IGHG4 | -6480 | -3573 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
CD22 mediated BCR regulation
| metric | value |
|---|---|
| setSize | 58 |
| pMANOVA | 2.23e-20 |
| p.adjustMANOVA | 1.9e-18 |
| s.dist | 0.539 |
| s.low.CRP | 0.069 |
| s.high.CRP | -0.534 |
| p.low.CRP | 0.363 |
| p.high.CRP | 1.87e-12 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
| IGLV1-44 | 3169 | -7580 |
| IGLV3-19 | 2884 | -7478 |
| IGHV1-2 | 7949 | -2404 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CD22 | -4690 | -6104 |
| CD79A | -6293 | -3766 |
| CD79B | -8417 | -6298 |
| IGHD | -3784 | -6091 |
| IGHM | -323 | -1745 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| LYN | 8483 | 8583 |
| PTPN6 | 3230 | 7923 |
Creation of C4 and C2 activators
| metric | value |
|---|---|
| setSize | 70 |
| pMANOVA | 8.44e-23 |
| p.adjustMANOVA | 9.58e-21 |
| s.dist | 0.497 |
| s.low.CRP | 0.112 |
| s.high.CRP | -0.484 |
| p.low.CRP | 0.106 |
| p.high.CRP | 2.41e-12 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
| IGLV1-44 | 3169 | -7580 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| C1QA | 2730 | 7449 |
| C1QB | 7676 | 9366 |
| C1QC | 8977 | 9784 |
| C1R | -9046 | -4725 |
| C1S | -1133 | 4982 |
| FCN1 | 10313 | 9522 |
| IGHG1 | -3727 | -9610 |
| IGHG2 | -2988 | -6697 |
| IGHG3 | 3688 | -4504 |
| IGHG4 | -6480 | -3573 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| MASP2 | 836 | -2977 |
FCGR activation
| metric | value |
|---|---|
| setSize | 75 |
| pMANOVA | 8.3e-23 |
| p.adjustMANOVA | 9.58e-21 |
| s.dist | 0.494 |
| s.low.CRP | 0.0799 |
| s.high.CRP | -0.488 |
| p.low.CRP | 0.231 |
| p.high.CRP | 2.73e-13 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
| IGLV1-44 | 3169 | -7580 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CD247 | -10994 | -10515 |
| CD3G | -8283 | -10568 |
| FCGR1A | 10365 | 10249 |
| FCGR2A | 9647 | 9000 |
| FCGR3A | -11031 | -7169 |
| FGR | 7776 | 10127 |
| FYN | -10683 | -7016 |
| HCK | 10073 | 9850 |
| IGHG1 | -3727 | -9610 |
| IGHG2 | -2988 | -6697 |
| IGHG3 | 3688 | -4504 |
| IGHG4 | -6480 | -3573 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| LYN | 8483 | 8583 |
| SRC | -4936 | -8846 |
| SYK | 9750 | 10350 |
| YES1 | -10892 | -9337 |
Initial triggering of complement
| metric | value |
|---|---|
| setSize | 77 |
| pMANOVA | 1.26e-22 |
| p.adjustMANOVA | 1.32e-20 |
| s.dist | 0.471 |
| s.low.CRP | 0.109 |
| s.high.CRP | -0.458 |
| p.low.CRP | 0.0993 |
| p.high.CRP | 3.62e-12 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
| IGLV1-44 | 3169 | -7580 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| C1QA | 2730 | 7449 |
| C1QB | 7676 | 9366 |
| C1QC | 8977 | 9784 |
| C1R | -9046 | -4725 |
| C1S | -1133 | 4982 |
| C2 | 9215 | 6100 |
| C3 | -10957 | -10571 |
| C4A | 6469 | 1331 |
| C4B | 3894 | -2194 |
| CFB | 4527 | 1298 |
| CFD | 911 | -342 |
| FCN1 | 10313 | 9522 |
| GZMM | -10508 | -10275 |
| IGHG1 | -3727 | -9610 |
| IGHG2 | -2988 | -6697 |
| IGHG3 | 3688 | -4504 |
| IGHG4 | -6480 | -3573 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| MASP2 | 836 | -2977 |
Role of LAT2/NTAL/LAB on calcium mobilization
| metric | value |
|---|---|
| setSize | 73 |
| pMANOVA | 1.98e-19 |
| p.adjustMANOVA | 1.3e-17 |
| s.dist | 0.426 |
| s.low.CRP | 0.15 |
| s.high.CRP | -0.399 |
| p.low.CRP | 0.0271 |
| p.high.CRP | 3.62e-09 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
| IGLV1-44 | 3169 | -7580 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| FYN | -10683 | -7016 |
| GAB2 | 6405 | 10289 |
| GRB2 | 9960 | 10389 |
| IGHE | -4940 | -4979 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| LAT2 | 8450 | 9858 |
| LYN | 8483 | 8583 |
| PDPK1 | -54 | 8056 |
| PIK3CA | 5168 | 6821 |
| PIK3CB | 9880 | 9707 |
| PIK3R1 | -7314 | -9108 |
| PIK3R2 | 2369 | 6022 |
| SHC1 | 3101 | 5292 |
| SOS1 | 2394 | -4661 |
| SYK | 9750 | 10350 |
Binding and Uptake of Ligands by Scavenger Receptors
| metric | value |
|---|---|
| setSize | 91 |
| pMANOVA | 2.01e-19 |
| p.adjustMANOVA | 1.3e-17 |
| s.dist | 0.36 |
| s.low.CRP | 0.214 |
| s.high.CRP | -0.289 |
| p.low.CRP | 0.000413 |
| p.high.CRP | 1.92e-06 |
| Gene | low CRP | high CRP |
|---|---|---|
| SCARF1 | 7980 | -9211 |
| IGHV3-30 | 6205 | -8897 |
| IGHA1 | 6020 | -8527 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| JCHAIN | 5415 | -8049 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ALB | 5157 | 1598 |
| APOE | -4921 | 3265 |
| APOL1 | 1106 | -9021 |
| CALR | 8310 | 6954 |
| CD163 | 10141 | 10559 |
| CD36 | 10363 | 10493 |
| COL1A2 | 4726 | 5641 |
| COL4A2 | -2203 | 4823 |
| COLEC12 | -10027 | 2954 |
| FTH1 | 1622 | 1016 |
| FTL | 9418 | 9788 |
| HBA1 | 9695 | 8704 |
| HBB | 9671 | 6093 |
| HP | 10242 | 10523 |
| HPX | 2028 | -3809 |
| HSP90AA1 | 5650 | 1245 |
| HSP90B1 | 8375 | 1593 |
| HSPH1 | -3822 | -6902 |
| HYOU1 | -4725 | 352 |
| IGHA1 | 6020 | -8527 |
| IGHA2 | 3566 | -2966 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| JCHAIN | 5415 | -8049 |
| LRP1 | 8118 | 10314 |
| MARCO | 7808 | 10448 |
| MSR1 | -1194 | 6317 |
| SCARB1 | 6192 | 5385 |
| SCARF1 | 7980 | -9211 |
| SCGB3A2 | -4719 | -668 |
| SPARC | 7330 | 7225 |
| SSC5D | -6156 | -4021 |
| STAB1 | 10304 | 10662 |
| STAB2 | 6753 | 7249 |
Purine ribonucleoside monophosphate biosynthesis
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00957 |
| p.adjustMANOVA | 0.026 |
| s.dist | 0.354 |
| s.low.CRP | 0.27 |
| s.high.CRP | -0.229 |
| p.low.CRP | 0.139 |
| p.high.CRP | 0.211 |
| Gene | low CRP | high CRP |
|---|---|---|
| PAICS | 8703 | -6208 |
| ATIC | 1721 | -9614 |
| LHPP | 6301 | -1033 |
| IMPDH2 | 543 | -9049 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ADSL | 9232 | 4663 |
| ATIC | 1721 | -9614 |
| GART | 488 | 6283 |
| GMPS | -142 | -604 |
| IMPDH1 | 10166 | 10137 |
| IMPDH2 | 543 | -9049 |
| LHPP | 6301 | -1033 |
| PAICS | 8703 | -6208 |
| PFAS | -9312 | -9384 |
| PPAT | -2103 | -9864 |
Regulation of Complement cascade
| metric | value |
|---|---|
| setSize | 93 |
| pMANOVA | 1.3e-19 |
| p.adjustMANOVA | 9.59e-18 |
| s.dist | 0.366 |
| s.low.CRP | 0.174 |
| s.high.CRP | -0.322 |
| p.low.CRP | 0.0038 |
| p.high.CRP | 7.8e-08 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| CFH | 4430 | -8637 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| C1QA | 2730 | 7449 |
| C1QB | 7676 | 9366 |
| C1QC | 8977 | 9784 |
| C1R | -9046 | -4725 |
| C1S | -1133 | 4982 |
| C2 | 9215 | 6100 |
| C3 | -10957 | -10571 |
| C3AR1 | 8008 | 9376 |
| C4A | 6469 | 1331 |
| C4B | 3894 | -2194 |
| C4BPB | 2719 | -2804 |
| C5 | 6559 | 4756 |
| C5AR1 | 9773 | 10201 |
| C5AR2 | 8236 | 7910 |
| C8G | -10359 | -8822 |
| CD19 | -5755 | -965 |
| CD46 | 7723 | 3480 |
| CD55 | 9747 | 10312 |
| CD59 | 6386 | 4199 |
| CD81 | -10198 | -7220 |
| CFB | 4527 | 1298 |
| CFH | 4430 | -8637 |
| CLU | 8797 | 10607 |
| CPN2 | 4742 | 5903 |
| CR1 | 10309 | 10566 |
| CR2 | -1369 | -1274 |
| ELANE | 10082 | 5779 |
| IGHG1 | -3727 | -9610 |
| IGHG2 | -2988 | -6697 |
| IGHG3 | 3688 | -4504 |
| IGHG4 | -6480 | -3573 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| PROS1 | 8002 | 7705 |
| SERPING1 | 533 | -10700 |
| VTN | 714 | 1913 |
HDMs demethylate histones
| metric | value |
|---|---|
| setSize | 22 |
| pMANOVA | 4.72e-05 |
| p.adjustMANOVA | 0.000226 |
| s.dist | 0.349 |
| s.low.CRP | -0.228 |
| s.high.CRP | 0.265 |
| p.low.CRP | 0.0642 |
| p.high.CRP | 0.0316 |
| Gene | low CRP | high CRP |
|---|---|---|
| KDM5B | -7531 | 7413 |
| KDM5C | -5713 | 4679 |
| KDM6A | -5857 | 3851 |
| KDM2A | -6005 | 3600 |
| KDM4A | -7903 | 2514 |
| KDM5A | -8525 | 2116 |
| ARID5B | -2817 | 4948 |
| PHF2 | -2036 | 5862 |
| PHF8 | -5970 | 1719 |
| KDM5D | -2513 | 413 |
| UTY | -4031 | 64 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ARID5B | -2817.0 | 4948.0 |
| H3C15 | 182.5 | 4598.5 |
| JMJD6 | 7702.0 | 5353.0 |
| KDM1A | -8434.0 | -1742.0 |
| KDM1B | 5408.0 | 4685.0 |
| KDM2A | -6005.0 | 3600.0 |
| KDM2B | -10742.0 | -8089.0 |
| KDM3A | -10046.0 | -10564.0 |
| KDM3B | 3644.0 | 9703.0 |
| KDM4A | -7903.0 | 2514.0 |
| KDM4B | 4813.0 | 8095.0 |
| KDM4C | -10769.0 | -2441.0 |
| KDM5A | -8525.0 | 2116.0 |
| KDM5B | -7531.0 | 7413.0 |
| KDM5C | -5713.0 | 4679.0 |
| KDM5D | -2513.0 | 413.0 |
| KDM6A | -5857.0 | 3851.0 |
| KDM6B | 9106.0 | 8232.0 |
| KDM7A | 7096.0 | 6765.0 |
| PHF2 | -2036.0 | 5862.0 |
| PHF8 | -5970.0 | 1719.0 |
| UTY | -4031.0 | 64.0 |
Trafficking of GluR2-containing AMPA receptors
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.000426 |
| p.adjustMANOVA | 0.00162 |
| s.dist | 0.577 |
| s.low.CRP | 0.0817 |
| s.high.CRP | 0.571 |
| p.low.CRP | 0.624 |
| p.high.CRP | 0.00061 |
| Gene | low CRP | high CRP |
|---|---|---|
| NSF | 8767 | 10358 |
| AP2S1 | 8593 | 9630 |
| AP2M1 | 7928 | 9269 |
| AP2A2 | 5529 | 9467 |
| TSPAN7 | 3431 | 8972 |
| PRKCA | 2691 | 1966 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AP2A1 | -5326 | 9611 |
| AP2A2 | 5529 | 9467 |
| AP2B1 | -8369 | 3155 |
| AP2M1 | 7928 | 9269 |
| AP2S1 | 8593 | 9630 |
| GRIA4 | -859 | 4722 |
| GRIP1 | -5247 | -10144 |
| NSF | 8767 | 10358 |
| PICK1 | -5745 | 7024 |
| PRKCA | 2691 | 1966 |
| PRKCB | -4906 | 9024 |
| TSPAN7 | 3431 | 8972 |
Complement cascade
| metric | value |
|---|---|
| setSize | 97 |
| pMANOVA | 2.43e-19 |
| p.adjustMANOVA | 1.51e-17 |
| s.dist | 0.356 |
| s.low.CRP | 0.169 |
| s.high.CRP | -0.313 |
| p.low.CRP | 0.00396 |
| p.high.CRP | 1e-07 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| CFH | 4430 | -8637 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| C1QA | 2730 | 7449 |
| C1QB | 7676 | 9366 |
| C1QC | 8977 | 9784 |
| C1R | -9046 | -4725 |
| C1S | -1133 | 4982 |
| C2 | 9215 | 6100 |
| C3 | -10957 | -10571 |
| C3AR1 | 8008 | 9376 |
| C4A | 6469 | 1331 |
| C4B | 3894 | -2194 |
| C4BPB | 2719 | -2804 |
| C5 | 6559 | 4756 |
| C5AR1 | 9773 | 10201 |
| C5AR2 | 8236 | 7910 |
| C8G | -10359 | -8822 |
| CD19 | -5755 | -965 |
| CD46 | 7723 | 3480 |
| CD55 | 9747 | 10312 |
| CD59 | 6386 | 4199 |
| CD81 | -10198 | -7220 |
| CFB | 4527 | 1298 |
| CFD | 911 | -342 |
| CFH | 4430 | -8637 |
| CLU | 8797 | 10607 |
| CPN2 | 4742 | 5903 |
| CR1 | 10309 | 10566 |
| CR2 | -1369 | -1274 |
| ELANE | 10082 | 5779 |
| FCN1 | 10313 | 9522 |
| GZMM | -10508 | -10275 |
| IGHG1 | -3727 | -9610 |
| IGHG2 | -2988 | -6697 |
| IGHG3 | 3688 | -4504 |
| IGHG4 | -6480 | -3573 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| MASP2 | 836 | -2977 |
| PROS1 | 8002 | 7705 |
| SERPING1 | 533 | -10700 |
| VTN | 714 | 1913 |
Nucleobase biosynthesis
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00362 |
| p.adjustMANOVA | 0.011 |
| s.dist | 0.349 |
| s.low.CRP | 0.176 |
| s.high.CRP | -0.302 |
| p.low.CRP | 0.273 |
| p.high.CRP | 0.0594 |
| Gene | low CRP | high CRP |
|---|---|---|
| PAICS | 8703 | -6208 |
| ATIC | 1721 | -9614 |
| LHPP | 6301 | -1033 |
| IMPDH2 | 543 | -9049 |
| DHODH | 1604 | -387 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ADSL | 9232 | 4663 |
| ATIC | 1721 | -9614 |
| CAD | -5411 | -8350 |
| DHODH | 1604 | -387 |
| GART | 488 | 6283 |
| GMPS | -142 | -604 |
| IMPDH1 | 10166 | 10137 |
| IMPDH2 | 543 | -9049 |
| LHPP | 6301 | -1033 |
| PAICS | 8703 | -6208 |
| PFAS | -9312 | -9384 |
| PPAT | -2103 | -9864 |
| UMPS | -1722 | -8876 |
Removal of the Flap Intermediate
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.00154 |
| p.adjustMANOVA | 0.00514 |
| s.dist | 0.41 |
| s.low.CRP | 0.0624 |
| s.high.CRP | -0.405 |
| p.low.CRP | 0.686 |
| p.high.CRP | 0.00867 |
| Gene | low CRP | high CRP |
|---|---|---|
| DNA2 | 6561 | -5890 |
| PCNA | 5892 | -5806 |
| PRIM1 | 3517 | -8072 |
| POLD2 | 1884 | -9615 |
| RPA3 | 2134 | -6039 |
| RPA2 | 1724 | -6042 |
| PRIM2 | 222 | -692 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| DNA2 | 6561 | -5890 |
| FEN1 | -5020 | -7778 |
| PCNA | 5892 | -5806 |
| POLA1 | -9840 | -10651 |
| POLA2 | -3815 | -9468 |
| POLD1 | -1902 | 214 |
| POLD2 | 1884 | -9615 |
| POLD3 | 9399 | 10511 |
| POLD4 | 3672 | 8000 |
| PRIM1 | 3517 | -8072 |
| PRIM2 | 222 | -692 |
| RPA1 | -9749 | -9650 |
| RPA2 | 1724 | -6042 |
| RPA3 | 2134 | -6039 |
Pre-NOTCH Processing in Golgi
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 0.000211 |
| p.adjustMANOVA | 0.000852 |
| s.dist | 0.42 |
| s.low.CRP | -0.0506 |
| s.high.CRP | 0.417 |
| p.low.CRP | 0.71 |
| p.high.CRP | 0.0022 |
| Gene | low CRP | high CRP |
|---|---|---|
| NOTCH3 | -7507 | 10318 |
| ST3GAL4 | -9447 | 4972 |
| NOTCH4 | -10239 | 2947 |
| B4GALT1 | -3872 | 6820 |
| NOTCH1 | -6741 | 1205 |
| ST3GAL3 | -1028 | 2393 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ATP2A1 | -4842 | -734 |
| ATP2A2 | 7987 | 8967 |
| ATP2A3 | -10436 | -1355 |
| B4GALT1 | -3872 | 6820 |
| FURIN | 7688 | 10324 |
| LFNG | -9696 | -5364 |
| MFNG | -5389 | -4960 |
| NOTCH1 | -6741 | 1205 |
| NOTCH2 | 1164 | 5400 |
| NOTCH3 | -7507 | 10318 |
| NOTCH4 | -10239 | 2947 |
| RAB6A | 8383 | 9332 |
| RFNG | 5961 | 8156 |
| SEL1L | 6263 | 8390 |
| ST3GAL3 | -1028 | 2393 |
| ST3GAL4 | -9447 | 4972 |
| ST3GAL6 | 9322 | 5613 |
| TMED2 | 6691 | 7410 |
Processive synthesis on the lagging strand
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.000816 |
| p.adjustMANOVA | 0.00292 |
| s.dist | 0.438 |
| s.low.CRP | 0.0213 |
| s.high.CRP | -0.438 |
| p.low.CRP | 0.886 |
| p.high.CRP | 0.00333 |
| Gene | low CRP | high CRP |
|---|---|---|
| DNA2 | 6561 | -5890 |
| PCNA | 5892 | -5806 |
| PRIM1 | 3517 | -8072 |
| POLD2 | 1884 | -9615 |
| RPA3 | 2134 | -6039 |
| RPA2 | 1724 | -6042 |
| PRIM2 | 222 | -692 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| DNA2 | 6561 | -5890 |
| FEN1 | -5020 | -7778 |
| LIG1 | -6259 | -9583 |
| PCNA | 5892 | -5806 |
| POLA1 | -9840 | -10651 |
| POLA2 | -3815 | -9468 |
| POLD1 | -1902 | 214 |
| POLD2 | 1884 | -9615 |
| POLD3 | 9399 | 10511 |
| POLD4 | 3672 | 8000 |
| PRIM1 | 3517 | -8072 |
| PRIM2 | 222 | -692 |
| RPA1 | -9749 | -9650 |
| RPA2 | 1724 | -6042 |
| RPA3 | 2134 | -6039 |
Role of phospholipids in phagocytosis
| metric | value |
|---|---|
| setSize | 87 |
| pMANOVA | 3.75e-17 |
| p.adjustMANOVA | 1.89e-15 |
| s.dist | 0.401 |
| s.low.CRP | 0.0544 |
| s.high.CRP | -0.397 |
| p.low.CRP | 0.381 |
| p.high.CRP | 1.45e-10 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
| IGLV1-44 | 3169 | -7580 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AHCYL1 | 4949 | 8470 |
| CD247 | -10994 | -10515 |
| CD3G | -8283 | -10568 |
| FCGR1A | 10365 | 10249 |
| FCGR2A | 9647 | 9000 |
| FCGR3A | -11031 | -7169 |
| IGHG1 | -3727 | -9610 |
| IGHG2 | -2988 | -6697 |
| IGHG3 | 3688 | -4504 |
| IGHG4 | -6480 | -3573 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| ITPR1 | -9755 | -3689 |
| ITPR2 | 4786 | 9335 |
| ITPR3 | -8426 | -7902 |
| PIK3CA | 5168 | 6821 |
| PIK3CB | 9880 | 9707 |
| PIK3R1 | -7314 | -9108 |
| PIK3R2 | 2369 | 6022 |
| PLA2G6 | -10438 | -10350 |
| PLCG1 | -5836 | -10187 |
| PLCG2 | -6227 | 6708 |
| PLD1 | 10119 | 10572 |
| PLD2 | 6138 | 9091 |
| PLD3 | 8046 | 6488 |
| PLD4 | -11002 | -10493 |
| PLPP5 | -9164 | -5630 |
| PRKCD | 9710 | 9721 |
| PRKCE | -10688 | -925 |
| SYK | 9750 | 10350 |
Elevation of cytosolic Ca2+ levels
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0146 |
| p.adjustMANOVA | 0.0373 |
| s.dist | 0.309 |
| s.low.CRP | -0.242 |
| s.high.CRP | 0.192 |
| p.low.CRP | 0.147 |
| p.high.CRP | 0.249 |
| Gene | low CRP | high CRP |
|---|---|---|
| STIM1 | -9782 | 6145 |
| TRPC6 | -7554 | 2174 |
| ORAI2 | -2897 | 4779 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ITPR1 | -9755 | -3689 |
| ITPR2 | 4786 | 9335 |
| ITPR3 | -8426 | -7902 |
| ORAI1 | -8363 | -7067 |
| ORAI2 | -2897 | 4779 |
| P2RX1 | 566 | 10417 |
| P2RX4 | 9476 | 9713 |
| P2RX5 | -2226 | -755 |
| P2RX7 | 7506 | 2020 |
| STIM1 | -9782 | 6145 |
| TRPC3 | -8356 | -765 |
| TRPC6 | -7554 | 2174 |
FCERI mediated MAPK activation
| metric | value |
|---|---|
| setSize | 89 |
| pMANOVA | 2.28e-14 |
| p.adjustMANOVA | 7.96e-13 |
| s.dist | 0.318 |
| s.low.CRP | 0.152 |
| s.high.CRP | -0.279 |
| p.low.CRP | 0.0129 |
| p.high.CRP | 5.51e-06 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
| IGLV1-44 | 3169 | -7580 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| FOS | 7518 | 2641 |
| GRAP2 | -2556 | 4557 |
| GRB2 | 9960 | 10389 |
| HRAS | 2906 | -3843 |
| IGHE | -4940 | -4979 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| JUN | 481 | -1015 |
| KRAS | 4388 | 5328 |
| LAT | -8158 | -10401 |
| LCP2 | 5338 | -3004 |
| LYN | 8483 | 8583 |
| MAP2K4 | 5525 | 7430 |
| MAP2K7 | -1568 | 2972 |
| MAP3K1 | 380 | 8292 |
| MAPK1 | -1086 | 9427 |
| MAPK10 | 6946 | 6199 |
| MAPK3 | 9769 | 9676 |
| MAPK8 | -794 | -7374 |
| MAPK9 | -6911 | 1519 |
| NRAS | 8582 | 7708 |
| PAK1 | 10129 | 7653 |
| PAK2 | 9098 | 8874 |
| PLCG1 | -5836 | -10187 |
| PLCG2 | -6227 | 6708 |
| RAC1 | 9345 | 9946 |
| SHC1 | 3101 | 5292 |
| SOS1 | 2394 | -4661 |
| SYK | 9750 | 10350 |
| VAV1 | 6299 | 7892 |
| VAV2 | -9043 | 2054 |
| VAV3 | -7486 | 7780 |
FCERI mediated Ca+2 mobilization
| metric | value |
|---|---|
| setSize | 88 |
| pMANOVA | 1.9e-14 |
| p.adjustMANOVA | 6.96e-13 |
| s.dist | 0.36 |
| s.low.CRP | 0.0586 |
| s.high.CRP | -0.355 |
| p.low.CRP | 0.342 |
| p.high.CRP | 8.57e-09 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
| IGLV1-44 | 3169 | -7580 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AHCYL1 | 4949 | 8470 |
| BTK | 5823 | 9633 |
| CALM1 | -4337 | 1051 |
| GRAP2 | -2556 | 4557 |
| GRB2 | 9960 | 10389 |
| IGHE | -4940 | -4979 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| ITK | -5396 | -10354 |
| ITPR1 | -9755 | -3689 |
| ITPR2 | 4786 | 9335 |
| ITPR3 | -8426 | -7902 |
| LAT | -8158 | -10401 |
| LCP2 | 5338 | -3004 |
| LYN | 8483 | 8583 |
| NFATC1 | -9820 | -3625 |
| NFATC2 | -10949 | -10428 |
| NFATC3 | -10649 | -10621 |
| PLCG1 | -5836 | -10187 |
| PLCG2 | -6227 | 6708 |
| PPP3CA | 3489 | 7766 |
| PPP3CB | 9261 | 8237 |
| PPP3R1 | 8749 | 9050 |
| SHC1 | 3101 | 5292 |
| SOS1 | 2394 | -4661 |
| SYK | 9750 | 10350 |
| TEC | 6790 | 9842 |
| TXK | -9126 | -9892 |
| VAV1 | 6299 | 7892 |
| VAV2 | -9043 | 2054 |
| VAV3 | -7486 | 7780 |
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
| metric | value |
|---|---|
| setSize | 22 |
| pMANOVA | 5.74e-05 |
| p.adjustMANOVA | 0.000271 |
| s.dist | 0.472 |
| s.low.CRP | 0.058 |
| s.high.CRP | 0.468 |
| p.low.CRP | 0.638 |
| p.high.CRP | 0.000142 |
| Gene | low CRP | high CRP |
|---|---|---|
| H2AJ | 8738.0 | 10604.0 |
| H3-3A | 9562.0 | 8829.0 |
| H2BC21 | 8299.0 | 10036.0 |
| H2BC12 | 7081.0 | 10193.0 |
| H2AZ1 | 7009.0 | 5660.0 |
| H2AC6 | 4729.0 | 7926.0 |
| H2BC11 | 3513.0 | 8859.0 |
| KLK2 | 4896.0 | 6105.0 |
| H2BC5 | 3700.0 | 7898.0 |
| H2BC17 | 2507.0 | 9311.0 |
| H2BC4 | 1910.0 | 8229.0 |
| H2BC9 | 1386.0 | 3852.0 |
| H3C15 | 182.5 | 4598.5 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AR | -1905.0 | 4565.0 |
| H2AC20 | -3045.0 | 2635.0 |
| H2AC6 | 4729.0 | 7926.0 |
| H2AJ | 8738.0 | 10604.0 |
| H2AZ1 | 7009.0 | 5660.0 |
| H2AZ2 | -809.0 | 1701.0 |
| H2BC11 | 3513.0 | 8859.0 |
| H2BC12 | 7081.0 | 10193.0 |
| H2BC15 | -7054.0 | 7711.0 |
| H2BC17 | 2507.0 | 9311.0 |
| H2BC21 | 8299.0 | 10036.0 |
| H2BC4 | 1910.0 | 8229.0 |
| H2BC5 | 3700.0 | 7898.0 |
| H2BC9 | 1386.0 | 3852.0 |
| H2BU1 | -7775.0 | -6129.0 |
| H3-3A | 9562.0 | 8829.0 |
| H3C15 | 182.5 | 4598.5 |
| KDM1A | -8434.0 | -1742.0 |
| KDM4C | -10769.0 | -2441.0 |
| KLK2 | 4896.0 | 6105.0 |
| NCOA2 | -7260.0 | 1011.0 |
| PKN1 | -10152.0 | 280.0 |
PCNA-Dependent Long Patch Base Excision Repair
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 0.000545 |
| p.adjustMANOVA | 0.00204 |
| s.dist | 0.388 |
| s.low.CRP | 0.00603 |
| s.high.CRP | -0.388 |
| p.low.CRP | 0.962 |
| p.high.CRP | 0.00208 |
| Gene | low CRP | high CRP |
|---|---|---|
| POLB | 8076 | -6859 |
| PCNA | 5892 | -5806 |
| POLD2 | 1884 | -9615 |
| RPA3 | 2134 | -6039 |
| RPA2 | 1724 | -6042 |
| RFC4 | 408 | -7942 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| APEX1 | -243 | -8038 |
| FEN1 | -5020 | -7778 |
| LIG1 | -6259 | -9583 |
| PCNA | 5892 | -5806 |
| POLB | 8076 | -6859 |
| POLD1 | -1902 | 214 |
| POLD2 | 1884 | -9615 |
| POLD3 | 9399 | 10511 |
| POLD4 | 3672 | 8000 |
| POLE | -2578 | -6781 |
| POLE2 | -1604 | -8696 |
| POLE3 | -6845 | -7138 |
| POLE4 | 6287 | 4237 |
| RFC1 | -3854 | -3455 |
| RFC2 | 3972 | 7041 |
| RFC3 | -1375 | -8150 |
| RFC4 | 408 | -7942 |
| RFC5 | -9668 | -6038 |
| RPA1 | -9749 | -9650 |
| RPA2 | 1724 | -6042 |
| RPA3 | 2134 | -6039 |
WNT5A-dependent internalization of FZD4
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00181 |
| p.adjustMANOVA | 0.00591 |
| s.dist | 0.54 |
| s.low.CRP | 0.133 |
| s.high.CRP | 0.523 |
| p.low.CRP | 0.405 |
| p.high.CRP | 0.00109 |
| Gene | low CRP | high CRP |
|---|---|---|
| CLTC | 9482 | 10359 |
| CLTA | 9206 | 9264 |
| AP2S1 | 8593 | 9630 |
| ARRB2 | 8232 | 9058 |
| AP2M1 | 7928 | 9269 |
| AP2A2 | 5529 | 9467 |
| CLTB | 891 | 6664 |
| PRKCA | 2691 | 1966 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AP2A1 | -5326 | 9611 |
| AP2A2 | 5529 | 9467 |
| AP2B1 | -8369 | 3155 |
| AP2M1 | 7928 | 9269 |
| AP2S1 | 8593 | 9630 |
| ARRB2 | 8232 | 9058 |
| CLTA | 9206 | 9264 |
| CLTB | 891 | 6664 |
| CLTC | 9482 | 10359 |
| DVL2 | -9587 | -8307 |
| FZD4 | -10151 | -6695 |
| PRKCA | 2691 | 1966 |
| PRKCB | -4906 | 9024 |
Lagging Strand Synthesis
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.000576 |
| p.adjustMANOVA | 0.00214 |
| s.dist | 0.415 |
| s.low.CRP | -0.0254 |
| s.high.CRP | -0.415 |
| p.low.CRP | 0.844 |
| p.high.CRP | 0.00133 |
| Gene | low CRP | high CRP |
|---|---|---|
| POLA1 | -9840 | -10651 |
| RPA1 | -9749 | -9650 |
| LIG1 | -6259 | -9583 |
| RFC5 | -9668 | -6038 |
| FEN1 | -5020 | -7778 |
| POLA2 | -3815 | -9468 |
| RFC1 | -3854 | -3455 |
| RFC3 | -1375 | -8150 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| DNA2 | 6561 | -5890 |
| FEN1 | -5020 | -7778 |
| LIG1 | -6259 | -9583 |
| PCNA | 5892 | -5806 |
| POLA1 | -9840 | -10651 |
| POLA2 | -3815 | -9468 |
| POLD1 | -1902 | 214 |
| POLD2 | 1884 | -9615 |
| POLD3 | 9399 | 10511 |
| POLD4 | 3672 | 8000 |
| PRIM1 | 3517 | -8072 |
| PRIM2 | 222 | -692 |
| RFC1 | -3854 | -3455 |
| RFC2 | 3972 | 7041 |
| RFC3 | -1375 | -8150 |
| RFC4 | 408 | -7942 |
| RFC5 | -9668 | -6038 |
| RPA1 | -9749 | -9650 |
| RPA2 | 1724 | -6042 |
| RPA3 | 2134 | -6039 |
FCGR3A-mediated IL10 synthesis
| metric | value |
|---|---|
| setSize | 98 |
| pMANOVA | 8.68e-14 |
| p.adjustMANOVA | 2.75e-12 |
| s.dist | 0.334 |
| s.low.CRP | 0.0521 |
| s.high.CRP | -0.33 |
| p.low.CRP | 0.372 |
| p.high.CRP | 1.69e-08 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
| IGLV1-44 | 3169 | -7580 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ADCY2 | -3835 | 2899 |
| ADCY3 | 9752 | 10224 |
| ADCY4 | 4464 | 2329 |
| ADCY5 | -10012 | -4366 |
| ADCY6 | -5852 | -3739 |
| ADCY7 | -9455 | -1458 |
| ADCY9 | -8919 | 1933 |
| AHCYL1 | 4949 | 8470 |
| CALM1 | -4337 | 1051 |
| CD247 | -10994 | -10515 |
| CD3G | -8283 | -10568 |
| CREB1 | 2938 | -595 |
| FCGR1A | 10365 | 10249 |
| FCGR2A | 9647 | 9000 |
| FCGR3A | -11031 | -7169 |
| FGR | 7776 | 10127 |
| FYN | -10683 | -7016 |
| HCK | 10073 | 9850 |
| IGHG1 | -3727 | -9610 |
| IGHG2 | -2988 | -6697 |
| IGHG3 | 3688 | -4504 |
| IGHG4 | -6480 | -3573 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| IL10 | 9226 | 10431 |
| ITPR1 | -9755 | -3689 |
| ITPR2 | 4786 | 9335 |
| ITPR3 | -8426 | -7902 |
| LYN | 8483 | 8583 |
| PLCG1 | -5836 | -10187 |
| PLCG2 | -6227 | 6708 |
| PRKACA | 9995 | 10558 |
| PRKACB | -8479 | -10448 |
| PRKAR1A | 8904 | 9754 |
| PRKAR1B | 7778 | 8646 |
| PRKAR2A | 1151 | 7558 |
| PRKAR2B | 4069 | 6461 |
| PRKX | -4033 | -8552 |
| SRC | -4936 | -8846 |
| SYK | 9750 | 10350 |
| YES1 | -10892 | -9337 |
RORA activates gene expression
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 0.00502 |
| p.adjustMANOVA | 0.0147 |
| s.dist | 0.316 |
| s.low.CRP | -0.0708 |
| s.high.CRP | 0.308 |
| p.low.CRP | 0.603 |
| p.high.CRP | 0.0236 |
| Gene | low CRP | high CRP |
|---|---|---|
| NCOA6 | -5126 | 8092 |
| CHD9 | -7440 | 4616 |
| PPARA | -7992 | 2961 |
| CREBBP | -9358 | 1958 |
| NCOA1 | -3324 | 5089 |
| EP300 | -2315 | 7280 |
| NCOA2 | -7260 | 1011 |
| MED1 | -6238 | 727 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CARM1 | 9302 | 10024 |
| CHD9 | -7440 | 4616 |
| CPT1A | 2948 | 6756 |
| CREBBP | -9358 | 1958 |
| EP300 | -2315 | 7280 |
| HELZ2 | -10149 | -8681 |
| MED1 | -6238 | 727 |
| NCOA1 | -3324 | 5089 |
| NCOA2 | -7260 | 1011 |
| NCOA6 | -5126 | 8092 |
| PPARA | -7992 | 2961 |
| RORA | -10427 | -10611 |
| RXRA | 6389 | 8760 |
| SMARCD3 | 10015 | 8573 |
| SREBF1 | 8706 | 1961 |
| TBL1X | 6931 | 7717 |
| TBL1XR1 | 5299 | 5430 |
| TGS1 | 410 | -2742 |
Eukaryotic Translation Elongation
| metric | value |
|---|---|
| setSize | 92 |
| pMANOVA | 2.03e-12 |
| p.adjustMANOVA | 5.22e-11 |
| s.dist | 0.316 |
| s.low.CRP | 0.0708 |
| s.high.CRP | -0.308 |
| p.low.CRP | 0.24 |
| p.high.CRP | 3.33e-07 |
| Gene | low CRP | high CRP |
|---|---|---|
| RPS3A | 5865 | -3619 |
| EEF1A1P5 | 5880 | -3321 |
| RPS26 | 3527 | -5041 |
| RPL18 | 3381 | -4456 |
| EEF1A1 | 2936 | -4796 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
| RPL36AL | 5944 | -2052 |
| RPL5 | 4105 | -2796 |
| RPL4 | 4738 | -2403 |
| RPL12 | 2014 | -5298 |
| RPS25 | 2600 | -3817 |
| RPL13 | 2796 | -3228 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| RPL22 | 4761 | -1687 |
| RPL36A | 1606 | -4363 |
| RPL7 | 5143 | -1272 |
| RPLP0 | 6333 | -1009 |
| RPL11 | 1839 | -3327 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| EEF1A1 | 2936 | -4796 |
| EEF1A1P5 | 5880 | -3321 |
| EEF1A2 | -784 | -5416 |
| EEF1B2 | 1452 | -2929 |
| EEF1D | 1598 | -3621 |
| EEF1G | 2362 | -121 |
| EEF2 | -3419 | -1260 |
| FAU | -1127 | -1637 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| UBA52 | 2067 | 260 |
FCERI mediated NF-kB activation
| metric | value |
|---|---|
| setSize | 136 |
| pMANOVA | 3.65e-17 |
| p.adjustMANOVA | 1.89e-15 |
| s.dist | 0.3 |
| s.low.CRP | 0.288 |
| s.high.CRP | -0.0861 |
| p.low.CRP | 6.79e-09 |
| p.high.CRP | 0.0832 |
| Gene | low CRP | high CRP |
|---|---|---|
| CUL1 | 7475 | -10175 |
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGLV5-45 | 5252 | -9604 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGLV7-46 | 6144 | -6715 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| PSME2 | 3614 | -10267 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| PSMA5 | 6009 | -5256 |
| PSMA3 | 8811 | -3545 |
| PSMB8 | 5148 | -5793 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| BCL10 | 6535 | 3786 |
| BTRC | -7062 | 1812 |
| CARD11 | -10821 | -9353 |
| CDC34 | 7794 | 8739 |
| CHUK | 9608 | 9191 |
| CUL1 | 7475 | -10175 |
| FBXW11 | 3233 | 8725 |
| IGHE | -4940 | -4979 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-36 | -1581 | -5381 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV10-54 | 3553 | -6006 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-18 | 5165 | -4216 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-12 | -6620 | -5525 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV4-69 | -1909 | -6359 |
| IGLV5-45 | 5252 | -9604 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| IGLV7-46 | 6144 | -6715 |
| IGLV8-61 | 3943 | -3641 |
| IKBKB | -6356 | -1160 |
| IKBKG | -595 | 7203 |
| LYN | 8483 | 8583 |
| MALT1 | -1899 | -9188 |
| MAP3K7 | 2469 | 7237 |
| NFKB1 | 8527 | 5403 |
| NFKBIA | 8114 | 5809 |
| PDPK1 | -54 | 8056 |
| PRKCQ | -9967 | -10691 |
| PSMA1 | 9165 | 8953 |
| PSMA2 | 9175 | 6486 |
| PSMA3 | 8811 | -3545 |
| PSMA4 | 8595 | 258 |
| PSMA5 | 6009 | -5256 |
| PSMA6 | 9365 | 6915 |
| PSMA7 | 6006 | 7700 |
| PSMB1 | 8548 | 3242 |
| PSMB10 | -972 | -8733 |
| PSMB2 | 8065 | 5797 |
| PSMB3 | 8817 | 8326 |
| PSMB4 | 4018 | 3039 |
| PSMB5 | 8225 | 9508 |
| PSMB6 | 6959 | 8991 |
| PSMB7 | 9346 | 8950 |
| PSMB8 | 5148 | -5793 |
| PSMB9 | -5133 | -10716 |
| PSMC1 | 7220 | 8544 |
| PSMC2 | 4967 | 6378 |
| PSMC3 | 2824 | 4673 |
| PSMC4 | -9365 | -3210 |
| PSMC5 | 2913 | 2050 |
| PSMC6 | 9832 | 7978 |
| PSMD1 | 8509 | 8974 |
| PSMD10 | 6347 | 2957 |
| PSMD11 | 8697 | 9183 |
| PSMD12 | 9648 | 8351 |
| PSMD13 | 7185 | 6511 |
| PSMD14 | 7985 | 5632 |
| PSMD2 | 7347 | 8049 |
| PSMD3 | 3057 | 6067 |
| PSMD4 | 8627 | 9334 |
| PSMD5 | 1520 | 8328 |
| PSMD6 | 9864 | 9375 |
| PSMD7 | 9212 | 6772 |
| PSMD8 | 6905 | 6585 |
| PSMD9 | 7407 | 8869 |
| PSME1 | -1137 | -9489 |
| PSME2 | 3614 | -10267 |
| PSME3 | 9544 | 8452 |
| PSME4 | -8419 | -464 |
| PSMF1 | 7685 | 5740 |
| RASGRP1 | -9188 | -10645 |
| RASGRP2 | -6869 | -9348 |
| RASGRP4 | 10117 | 10286 |
| RELA | -2847 | -1359 |
| RPS27A | -1868 | -5386 |
| SEM1 | 5210 | 6938 |
| SKP1 | 8911 | 4204 |
| TAB1 | 7080 | 3716 |
| TAB2 | 8556 | 6836 |
| TAB3 | 215 | 4794 |
| TRAF6 | -4471 | 1582 |
| UBA52 | 2067 | 260 |
| UBB | 7788 | 3835 |
| UBC | 2562 | 2822 |
| UBE2D1 | 10262 | 10093 |
| UBE2D2 | 5413 | 5174 |
| UBE2N | 7813 | 4195 |
| UBE2V1 | 8249 | 8108 |
Folding of actin by CCT/TriC
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00478 |
| p.adjustMANOVA | 0.0142 |
| s.dist | 0.603 |
| s.low.CRP | 0.57 |
| s.high.CRP | 0.197 |
| p.low.CRP | 0.00181 |
| p.high.CRP | 0.28 |
| Gene | low CRP | high CRP |
|---|---|---|
| ACTB | 10142 | 9915 |
| CCT8 | 9483 | 8073 |
| CCT5 | 9799 | 7374 |
| TCP1 | 9179 | 4168 |
| CCT4 | 7652 | 2442 |
| CCT6A | 5427 | 1447 |
| CCT3 | 1236 | 229 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ACTB | 10142 | 9915 |
| CCT2 | 6166 | -5938 |
| CCT3 | 1236 | 229 |
| CCT4 | 7652 | 2442 |
| CCT5 | 9799 | 7374 |
| CCT6A | 5427 | 1447 |
| CCT6B | -4718 | -5710 |
| CCT7 | 3238 | -1099 |
| CCT8 | 9483 | 8073 |
| TCP1 | 9179 | 4168 |
Peptide chain elongation
| metric | value |
|---|---|
| setSize | 87 |
| pMANOVA | 1.87e-11 |
| p.adjustMANOVA | 3.76e-10 |
| s.dist | 0.315 |
| s.low.CRP | 0.0617 |
| s.high.CRP | -0.309 |
| p.low.CRP | 0.32 |
| p.high.CRP | 6.31e-07 |
| Gene | low CRP | high CRP |
|---|---|---|
| RPS3A | 5865 | -3619 |
| RPS26 | 3527 | -5041 |
| RPL18 | 3381 | -4456 |
| EEF1A1 | 2936 | -4796 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
| RPL36AL | 5944 | -2052 |
| RPL5 | 4105 | -2796 |
| RPL4 | 4738 | -2403 |
| RPL12 | 2014 | -5298 |
| RPS25 | 2600 | -3817 |
| RPL13 | 2796 | -3228 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| RPL22 | 4761 | -1687 |
| RPL36A | 1606 | -4363 |
| RPL7 | 5143 | -1272 |
| RPLP0 | 6333 | -1009 |
| RPL11 | 1839 | -3327 |
| RPL6 | 4935 | -1237 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| EEF1A1 | 2936 | -4796 |
| EEF2 | -3419 | -1260 |
| FAU | -1127 | -1637 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| UBA52 | 2067 | 260 |
Formation of a pool of free 40S subunits
| metric | value |
|---|---|
| setSize | 99 |
| pMANOVA | 7.31e-12 |
| p.adjustMANOVA | 1.66e-10 |
| s.dist | 0.272 |
| s.low.CRP | 0.13 |
| s.high.CRP | -0.24 |
| p.low.CRP | 0.0259 |
| p.high.CRP | 3.76e-05 |
| Gene | low CRP | high CRP |
|---|---|---|
| RPS3A | 5865 | -3619 |
| RPS26 | 3527 | -5041 |
| RPL18 | 3381 | -4456 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
| RPL36AL | 5944 | -2052 |
| RPL5 | 4105 | -2796 |
| RPL4 | 4738 | -2403 |
| RPL12 | 2014 | -5298 |
| RPS25 | 2600 | -3817 |
| RPL13 | 2796 | -3228 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| RPL22 | 4761 | -1687 |
| EIF3B | 1444 | -5363 |
| RPL36A | 1606 | -4363 |
| RPL7 | 5143 | -1272 |
| RPLP0 | 6333 | -1009 |
| RPL11 | 1839 | -3327 |
| RPL6 | 4935 | -1237 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| EIF1AX | 8840 | 678 |
| EIF3A | 2392 | 2708 |
| EIF3B | 1444 | -5363 |
| EIF3C | -2681 | 3297 |
| EIF3D | 6457 | -101 |
| EIF3E | 8520 | 1078 |
| EIF3F | 1895 | 3147 |
| EIF3G | 1785 | 746 |
| EIF3H | 8550 | 5125 |
| EIF3I | 8018 | 5002 |
| EIF3J | 8650 | 3134 |
| EIF3K | 4950 | 1772 |
| EIF3L | 6453 | 2490 |
| EIF3M | 9649 | 3612 |
| FAU | -1127 | -1637 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| UBA52 | 2067 | 260 |
Viral mRNA Translation
| metric | value |
|---|---|
| setSize | 87 |
| pMANOVA | 5.41e-11 |
| p.adjustMANOVA | 9.57e-10 |
| s.dist | 0.298 |
| s.low.CRP | 0.0812 |
| s.high.CRP | -0.287 |
| p.low.CRP | 0.19 |
| p.high.CRP | 3.71e-06 |
| Gene | low CRP | high CRP |
|---|---|---|
| RPS3A | 5865 | -3619 |
| RPS26 | 3527 | -5041 |
| RPL18 | 3381 | -4456 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
| RPL36AL | 5944 | -2052 |
| RPL5 | 4105 | -2796 |
| RPL4 | 4738 | -2403 |
| RPL12 | 2014 | -5298 |
| RPS25 | 2600 | -3817 |
| RPL13 | 2796 | -3228 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| RPL22 | 4761 | -1687 |
| RPL36A | 1606 | -4363 |
| RPL7 | 5143 | -1272 |
| RPLP0 | 6333 | -1009 |
| RPL11 | 1839 | -3327 |
| RPL6 | 4935 | -1237 |
| RPS2 | 1634 | -3308 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| DNAJC3 | 9070 | 9215 |
| FAU | -1127 | -1637 |
| GRSF1 | 8535 | 5101 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| UBA52 | 2067 | 260 |
TNFs bind their physiological receptors
| metric | value |
|---|---|
| setSize | 25 |
| pMANOVA | 0.0015 |
| p.adjustMANOVA | 0.00503 |
| s.dist | 0.282 |
| s.low.CRP | 0.102 |
| s.high.CRP | -0.263 |
| p.low.CRP | 0.376 |
| p.high.CRP | 0.023 |
| Gene | low CRP | high CRP |
|---|---|---|
| EDA2R | 8666 | -6826 |
| TNFRSF4 | 6066 | -9404 |
| TNFRSF17 | 5457 | -9240 |
| LTA | 5225 | -9641 |
| TNFSF8 | 4822 | -8596 |
| EDA | 8903 | -3204 |
| TNFRSF18 | 2603 | -9291 |
| TNFSF15 | 1671 | -5343 |
| CD70 | 2259 | -2934 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CD27 | -25 | -8750 |
| CD70 | 2259 | -2934 |
| EDA | 8903 | -3204 |
| EDA2R | 8666 | -6826 |
| EDAR | -2069 | -7937 |
| EDARADD | -7631 | -10101 |
| LTA | 5225 | -9641 |
| TNFRSF13B | -3332 | -5270 |
| TNFRSF14 | -3751 | -7009 |
| TNFRSF17 | 5457 | -9240 |
| TNFRSF18 | 2603 | -9291 |
| TNFRSF1A | 10046 | 10283 |
| TNFRSF1B | -1892 | 8266 |
| TNFRSF25 | -213 | -10512 |
| TNFRSF4 | 6066 | -9404 |
| TNFRSF8 | -5130 | 7478 |
| TNFRSF9 | -3568 | -1393 |
| TNFSF11 | -7547 | -1017 |
| TNFSF13 | 8815 | 9829 |
| TNFSF13B | 9850 | 7312 |
| TNFSF14 | -7390 | -2046 |
| TNFSF15 | 1671 | -5343 |
| TNFSF4 | -3977 | 5224 |
| TNFSF8 | 4822 | -8596 |
| TNFSF9 | -8844 | -622 |
GAB1 signalosome
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.00264 |
| p.adjustMANOVA | 0.00834 |
| s.dist | 0.505 |
| s.low.CRP | 0.126 |
| s.high.CRP | 0.489 |
| p.low.CRP | 0.415 |
| p.high.CRP | 0.00152 |
| Gene | low CRP | high CRP |
|---|---|---|
| GRB2 | 9960 | 10389 |
| EGF | 8136 | 8196 |
| TGFA | 5895 | 9650 |
| PIK3CA | 5168 | 6821 |
| PTPN11 | 3471 | 9688 |
| GAB1 | 3626 | 8241 |
| PAG1 | 1967 | 6079 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AREG | -5505 | 9162 |
| CSK | -2015 | 6501 |
| EGF | 8136 | 8196 |
| EREG | -2190 | 5005 |
| GAB1 | 3626 | 8241 |
| GRB2 | 9960 | 10389 |
| HBEGF | -922 | 4467 |
| PAG1 | 1967 | 6079 |
| PIK3CA | 5168 | 6821 |
| PIK3R1 | -7314 | -9108 |
| PTPN11 | 3471 | 9688 |
| PXN | -1154 | 6730 |
| SRC | -4936 | -8846 |
| TGFA | 5895 | 9650 |
Selenocysteine synthesis
| metric | value |
|---|---|
| setSize | 91 |
| pMANOVA | 1.16e-11 |
| p.adjustMANOVA | 2.55e-10 |
| s.dist | 0.318 |
| s.low.CRP | 0.0466 |
| s.high.CRP | -0.315 |
| p.low.CRP | 0.443 |
| p.high.CRP | 2.04e-07 |
| Gene | low CRP | high CRP |
|---|---|---|
| RPS3A | 5865 | -3619 |
| RPS26 | 3527 | -5041 |
| RPL18 | 3381 | -4456 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
| RPL36AL | 5944 | -2052 |
| RPL5 | 4105 | -2796 |
| RPL4 | 4738 | -2403 |
| RPL12 | 2014 | -5298 |
| RPS25 | 2600 | -3817 |
| RPL13 | 2796 | -3228 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| RPL22 | 4761 | -1687 |
| RPL36A | 1606 | -4363 |
| RPL7 | 5143 | -1272 |
| RPLP0 | 6333 | -1009 |
| RPL11 | 1839 | -3327 |
| RPL6 | 4935 | -1237 |
| RPS2 | 1634 | -3308 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| EEFSEC | -6081 | -5395 |
| FAU | -1127 | -1637 |
| PSTK | -7923 | -5193 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| SARS1 | 496 | -3575 |
| SECISBP2 | -2529 | -9656 |
| SEPHS2 | 8821 | 8013 |
| SEPSECS | -6690 | -9390 |
| UBA52 | 2067 | 260 |
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
| metric | value |
|---|---|
| setSize | 83 |
| pMANOVA | 5.94e-11 |
| p.adjustMANOVA | 1.04e-09 |
| s.dist | 0.336 |
| s.low.CRP | 0.0226 |
| s.high.CRP | -0.335 |
| p.low.CRP | 0.721 |
| p.high.CRP | 1.29e-07 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGHV3-30 | 6205 | -8897 |
| IGKV1-5 | 5340 | -9482 |
| IGHV3-11 | 6603 | -6880 |
| IGKV1-12 | 4565 | -9660 |
| IGLV2-8 | 4817 | -8917 |
| IGKV3-11 | 4335 | -8929 |
| IGHV3-23 | 5184 | -7276 |
| IGKV1-33 | 5570 | -6751 |
| IGLV6-57 | 4672 | -7639 |
| IGKV4-1 | 5759 | -5700 |
| IGKC | 3871 | -8235 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV1-17 | 5659 | -4913 |
| IGLV2-23 | 4476 | -5875 |
| IGKV5-2 | 3670 | -6960 |
| IGKV1-16 | 4776 | -5235 |
| TRPC1 | 2523 | -9638 |
| IGLV1-44 | 3169 | -7580 |
| IGLV3-19 | 2884 | -7478 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AHCYL1 | 4949 | 8470 |
| BLK | -6450 | -461 |
| BLNK | -7737 | -4051 |
| BTK | 5823 | 9633 |
| CALM1 | -4337 | 1051 |
| CD19 | -5755 | -965 |
| CD22 | -4690 | -6104 |
| CD79A | -6293 | -3766 |
| CD79B | -8417 | -6298 |
| DAPP1 | 9506 | 2775 |
| FYN | -10683 | -7016 |
| GRB2 | 9960 | 10389 |
| IGHD | -3784 | -6091 |
| IGHM | -323 | -1745 |
| IGHV1-2 | 7949 | -2404 |
| IGHV1-46 | 1645 | -7097 |
| IGHV1-69 | -473 | -3585 |
| IGHV2-5 | -761 | -7784 |
| IGHV2-70 | -5110 | -2783 |
| IGHV3-11 | 6603 | -6880 |
| IGHV3-13 | -4367 | -5652 |
| IGHV3-23 | 5184 | -7276 |
| IGHV3-30 | 6205 | -8897 |
| IGHV3-33 | -1859 | -6548 |
| IGHV3-48 | 1158 | -4630 |
| IGHV3-53 | 439 | -4325 |
| IGHV3-7 | 2687 | -5396 |
| IGHV4-34 | -3831 | -5446 |
| IGHV4-39 | -3715 | -8660 |
| IGHV4-59 | 1427 | -4638 |
| IGKC | 3871 | -8235 |
| IGKV1-12 | 4565 | -9660 |
| IGKV1-16 | 4776 | -5235 |
| IGKV1-17 | 5659 | -4913 |
| IGKV1-33 | 5570 | -6751 |
| IGKV1-5 | 5340 | -9482 |
| IGKV1D-39 | 2361 | -3975 |
| IGKV2-28 | 600 | -6240 |
| IGKV2-30 | 2124 | -5952 |
| IGKV2D-28 | -8241 | -7171 |
| IGKV3-11 | 4335 | -8929 |
| IGKV3-15 | 3182 | -9110 |
| IGKV3-20 | 3477 | -8253 |
| IGKV3D-20 | -604 | -487 |
| IGKV4-1 | 5759 | -5700 |
| IGKV5-2 | 3670 | -6960 |
| IGLC1 | -2564 | -7780 |
| IGLC2 | -3391 | -9023 |
| IGLC3 | -211 | -3454 |
| IGLC7 | -5718 | -8734 |
| IGLV1-40 | -5815 | -8593 |
| IGLV1-44 | 3169 | -7580 |
| IGLV1-47 | -657 | -7558 |
| IGLV1-51 | -1719 | -7074 |
| IGLV2-11 | 1826 | -4201 |
| IGLV2-14 | -4545 | -8212 |
| IGLV2-23 | 4476 | -5875 |
| IGLV2-8 | 4817 | -8917 |
| IGLV3-1 | -5764 | -8993 |
| IGLV3-19 | 2884 | -7478 |
| IGLV3-21 | -1967 | -5619 |
| IGLV3-25 | -5461 | -6576 |
| IGLV3-27 | -8634 | -4435 |
| IGLV6-57 | 4672 | -7639 |
| IGLV7-43 | 165 | 2135 |
| ITPR1 | -9755 | -3689 |
| ITPR2 | 4786 | 9335 |
| ITPR3 | -8426 | -7902 |
| LYN | 8483 | 8583 |
| NCK1 | -8084 | -8497 |
| ORAI1 | -8363 | -7067 |
| ORAI2 | -2897 | 4779 |
| PIK3AP1 | 7061 | 8941 |
| PIK3CD | -932 | 3422 |
| PIK3R1 | -7314 | -9108 |
| PLCG2 | -6227 | 6708 |
| PTPN6 | 3230 | 7923 |
| SH3KBP1 | 2654 | 6905 |
| SOS1 | 2394 | -4661 |
| STIM1 | -9782 | 6145 |
| SYK | 9750 | 10350 |
| TRPC1 | 2523 | -9638 |
| VAV1 | 6299 | 7892 |
Formation of the ternary complex, and subsequently, the 43S complex
| metric | value |
|---|---|
| setSize | 51 |
| pMANOVA | 6.5e-06 |
| p.adjustMANOVA | 3.68e-05 |
| s.dist | 0.254 |
| s.low.CRP | 0.209 |
| s.high.CRP | -0.144 |
| p.low.CRP | 0.00978 |
| p.high.CRP | 0.0749 |
| Gene | low CRP | high CRP |
|---|---|---|
| RPS3A | 5865 | -3619 |
| RPS26 | 3527 | -5041 |
| RPS3 | 2486 | -5123 |
| RPS25 | 2600 | -3817 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| EIF3B | 1444 | -5363 |
| RPS2 | 1634 | -3308 |
| RPS15A | 1269 | -4048 |
| RPS7 | 1946 | -2271 |
| RPS23 | 772 | -4150 |
| RPS8 | 3760 | -769 |
| EIF3D | 6457 | -101 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| EIF1AX | 8840 | 678 |
| EIF2S1 | 9228 | 5747 |
| EIF2S2 | 9166 | 7187 |
| EIF2S3 | 7994 | 6909 |
| EIF3A | 2392 | 2708 |
| EIF3B | 1444 | -5363 |
| EIF3C | -2681 | 3297 |
| EIF3D | 6457 | -101 |
| EIF3E | 8520 | 1078 |
| EIF3F | 1895 | 3147 |
| EIF3G | 1785 | 746 |
| EIF3H | 8550 | 5125 |
| EIF3I | 8018 | 5002 |
| EIF3J | 8650 | 3134 |
| EIF3K | 4950 | 1772 |
| EIF3L | 6453 | 2490 |
| EIF3M | 9649 | 3612 |
| FAU | -1127 | -1637 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
Eukaryotic Translation Termination
| metric | value |
|---|---|
| setSize | 91 |
| pMANOVA | 9e-11 |
| p.adjustMANOVA | 1.5e-09 |
| s.dist | 0.296 |
| s.low.CRP | 0.0628 |
| s.high.CRP | -0.289 |
| p.low.CRP | 0.301 |
| p.high.CRP | 1.85e-06 |
| Gene | low CRP | high CRP |
|---|---|---|
| RPS3A | 5865 | -3619 |
| RPS26 | 3527 | -5041 |
| RPL18 | 3381 | -4456 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
| RPL36AL | 5944 | -2052 |
| RPL5 | 4105 | -2796 |
| RPL4 | 4738 | -2403 |
| RPL12 | 2014 | -5298 |
| RPS25 | 2600 | -3817 |
| RPL13 | 2796 | -3228 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| RPL22 | 4761 | -1687 |
| RPL36A | 1606 | -4363 |
| RPL7 | 5143 | -1272 |
| RPLP0 | 6333 | -1009 |
| RPL11 | 1839 | -3327 |
| RPL6 | 4935 | -1237 |
| RPS2 | 1634 | -3308 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| APEH | -6699 | 1881 |
| ETF1 | 9199 | 8093 |
| FAU | -1127 | -1637 |
| GSPT1 | 8890 | 4650 |
| GSPT2 | -5847 | -5423 |
| N6AMT1 | -6775 | -9870 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| TRMT112 | 3035 | 510 |
| UBA52 | 2067 | 260 |
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
| metric | value |
|---|---|
| setSize | 93 |
| pMANOVA | 1.52e-10 |
| p.adjustMANOVA | 2.25e-09 |
| s.dist | 0.278 |
| s.low.CRP | 0.0873 |
| s.high.CRP | -0.263 |
| p.low.CRP | 0.146 |
| p.high.CRP | 1.13e-05 |
| Gene | low CRP | high CRP |
|---|---|---|
| NCBP2 | 6179 | -5809 |
| RPS3A | 5865 | -3619 |
| RPS26 | 3527 | -5041 |
| RPL18 | 3381 | -4456 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
| RPL36AL | 5944 | -2052 |
| RPL5 | 4105 | -2796 |
| RPL4 | 4738 | -2403 |
| RPL12 | 2014 | -5298 |
| RPS25 | 2600 | -3817 |
| RPL13 | 2796 | -3228 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| RPL22 | 4761 | -1687 |
| RPL36A | 1606 | -4363 |
| RPL7 | 5143 | -1272 |
| RPLP0 | 6333 | -1009 |
| RPL11 | 1839 | -3327 |
| RPL6 | 4935 | -1237 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| EIF4G1 | 5724 | 10120 |
| ETF1 | 9199 | 8093 |
| FAU | -1127 | -1637 |
| GSPT1 | 8890 | 4650 |
| GSPT2 | -5847 | -5423 |
| NCBP1 | 2967 | -1011 |
| NCBP2 | 6179 | -5809 |
| PABPC1 | 7203 | 5354 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| UBA52 | 2067 | 260 |
| UPF1 | -7508 | 3221 |
BMAL1:CLOCK,NPAS2 activates circadian gene expression
| metric | value |
|---|---|
| setSize | 25 |
| pMANOVA | 0.00275 |
| p.adjustMANOVA | 0.00862 |
| s.dist | 0.264 |
| s.low.CRP | -0.11 |
| s.high.CRP | 0.24 |
| p.low.CRP | 0.343 |
| p.high.CRP | 0.0377 |
| Gene | low CRP | high CRP |
|---|---|---|
| KLF15 | -9390 | 4560 |
| NCOA6 | -5126 | 8092 |
| CHD9 | -7440 | 4616 |
| PPARA | -7992 | 2961 |
| CREBBP | -9358 | 1958 |
| NCOA1 | -3324 | 5089 |
| NOCT | -1391 | 7395 |
| NCOA2 | -7260 | 1011 |
| MED1 | -6238 | 727 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ARNTL | -10164 | -1541 |
| ARNTL2 | 10252 | 5317 |
| BHLHE40 | -9629 | -6132 |
| BHLHE41 | 3100 | -1651 |
| CARM1 | 9302 | 10024 |
| CHD9 | -7440 | 4616 |
| CLOCK | -6053 | -3825 |
| CREBBP | -9358 | 1958 |
| DBP | -8458 | -9488 |
| HELZ2 | -10149 | -8681 |
| KLF15 | -9390 | 4560 |
| MED1 | -6238 | 727 |
| NAMPT | 7122 | 7727 |
| NCOA1 | -3324 | 5089 |
| NCOA2 | -7260 | 1011 |
| NCOA6 | -5126 | 8092 |
| NOCT | -1391 | 7395 |
| NPAS2 | 2505 | -49 |
| PPARA | -7992 | 2961 |
| RXRA | 6389 | 8760 |
| SERPINE1 | 3011 | 7764 |
| SMARCD3 | 10015 | 8573 |
| TBL1X | 6931 | 7717 |
| TBL1XR1 | 5299 | 5430 |
| TGS1 | 410 | -2742 |
Response of EIF2AK4 (GCN2) to amino acid deficiency
| metric | value |
|---|---|
| setSize | 99 |
| pMANOVA | 6.63e-11 |
| p.adjustMANOVA | 1.13e-09 |
| s.dist | 0.269 |
| s.low.CRP | 0.0995 |
| s.high.CRP | -0.249 |
| p.low.CRP | 0.087 |
| p.high.CRP | 1.79e-05 |
| Gene | low CRP | high CRP |
|---|---|---|
| RPS3A | 5865 | -3619 |
| ASNS | 3189 | -6265 |
| RPS26 | 3527 | -5041 |
| RPL18 | 3381 | -4456 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
| RPL36AL | 5944 | -2052 |
| RPL5 | 4105 | -2796 |
| RPL4 | 4738 | -2403 |
| RPL12 | 2014 | -5298 |
| RPS25 | 2600 | -3817 |
| IMPACT | 7320 | -1351 |
| RPL13 | 2796 | -3228 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| RPL22 | 4761 | -1687 |
| RPL36A | 1606 | -4363 |
| RPL7 | 5143 | -1272 |
| RPLP0 | 6333 | -1009 |
| RPL11 | 1839 | -3327 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ASNS | 3189 | -6265 |
| ATF2 | 8316 | 2303 |
| ATF3 | -6766 | -10451 |
| ATF4 | 8523 | 6223 |
| CEBPB | 3064 | 8385 |
| CEBPG | 7532 | 7427 |
| DDIT3 | 2270 | 107 |
| EIF2AK4 | -331 | 2879 |
| EIF2S1 | 9228 | 5747 |
| EIF2S2 | 9166 | 7187 |
| EIF2S3 | 7994 | 6909 |
| FAU | -1127 | -1637 |
| GCN1 | -9131 | -7161 |
| IMPACT | 7320 | -1351 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| TRIB3 | -7114 | -4878 |
| UBA52 | 2067 | 260 |
L13a-mediated translational silencing of Ceruloplasmin expression
| metric | value |
|---|---|
| setSize | 109 |
| pMANOVA | 2.64e-11 |
| p.adjustMANOVA | 4.87e-10 |
| s.dist | 0.245 |
| s.low.CRP | 0.174 |
| s.high.CRP | -0.173 |
| p.low.CRP | 0.00166 |
| p.high.CRP | 0.00186 |
| Gene | low CRP | high CRP |
|---|---|---|
| RPS3A | 5865 | -3619 |
| RPS26 | 3527 | -5041 |
| RPL18 | 3381 | -4456 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
| RPL36AL | 5944 | -2052 |
| RPL5 | 4105 | -2796 |
| RPL4 | 4738 | -2403 |
| RPL12 | 2014 | -5298 |
| RPS25 | 2600 | -3817 |
| RPL13 | 2796 | -3228 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| RPL22 | 4761 | -1687 |
| EIF3B | 1444 | -5363 |
| RPL36A | 1606 | -4363 |
| RPL7 | 5143 | -1272 |
| RPLP0 | 6333 | -1009 |
| RPL11 | 1839 | -3327 |
| RPL6 | 4935 | -1237 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| EIF1AX | 8840 | 678 |
| EIF2S1 | 9228 | 5747 |
| EIF2S2 | 9166 | 7187 |
| EIF2S3 | 7994 | 6909 |
| EIF3A | 2392 | 2708 |
| EIF3B | 1444 | -5363 |
| EIF3C | -2681 | 3297 |
| EIF3D | 6457 | -101 |
| EIF3E | 8520 | 1078 |
| EIF3F | 1895 | 3147 |
| EIF3G | 1785 | 746 |
| EIF3H | 8550 | 5125 |
| EIF3I | 8018 | 5002 |
| EIF3J | 8650 | 3134 |
| EIF3K | 4950 | 1772 |
| EIF3L | 6453 | 2490 |
| EIF3M | 9649 | 3612 |
| EIF4A1 | 9825 | 8652 |
| EIF4A2 | -4531 | -9693 |
| EIF4B | 2213 | 1367 |
| EIF4E | 8016 | 7576 |
| EIF4G1 | 5724 | 10120 |
| EIF4H | 7558 | 9107 |
| FAU | -1127 | -1637 |
| PABPC1 | 7203 | 5354 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| UBA52 | 2067 | 260 |
GTP hydrolysis and joining of the 60S ribosomal subunit
| metric | value |
|---|---|
| setSize | 110 |
| pMANOVA | 2.25e-11 |
| p.adjustMANOVA | 4.33e-10 |
| s.dist | 0.245 |
| s.low.CRP | 0.172 |
| s.high.CRP | -0.174 |
| p.low.CRP | 0.0018 |
| p.high.CRP | 0.0016 |
| Gene | low CRP | high CRP |
|---|---|---|
| RPS3A | 5865 | -3619 |
| RPS26 | 3527 | -5041 |
| RPL18 | 3381 | -4456 |
| EIF5B | 5000 | -2620 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
| RPL36AL | 5944 | -2052 |
| RPL5 | 4105 | -2796 |
| RPL4 | 4738 | -2403 |
| RPL12 | 2014 | -5298 |
| RPS25 | 2600 | -3817 |
| RPL13 | 2796 | -3228 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| RPL22 | 4761 | -1687 |
| EIF3B | 1444 | -5363 |
| RPL36A | 1606 | -4363 |
| RPL7 | 5143 | -1272 |
| RPLP0 | 6333 | -1009 |
| RPL11 | 1839 | -3327 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| EIF1AX | 8840 | 678 |
| EIF2S1 | 9228 | 5747 |
| EIF2S2 | 9166 | 7187 |
| EIF2S3 | 7994 | 6909 |
| EIF3A | 2392 | 2708 |
| EIF3B | 1444 | -5363 |
| EIF3C | -2681 | 3297 |
| EIF3D | 6457 | -101 |
| EIF3E | 8520 | 1078 |
| EIF3F | 1895 | 3147 |
| EIF3G | 1785 | 746 |
| EIF3H | 8550 | 5125 |
| EIF3I | 8018 | 5002 |
| EIF3J | 8650 | 3134 |
| EIF3K | 4950 | 1772 |
| EIF3L | 6453 | 2490 |
| EIF3M | 9649 | 3612 |
| EIF4A1 | 9825 | 8652 |
| EIF4A2 | -4531 | -9693 |
| EIF4B | 2213 | 1367 |
| EIF4E | 8016 | 7576 |
| EIF4G1 | 5724 | 10120 |
| EIF4H | 7558 | 9107 |
| EIF5 | 1261 | 4191 |
| EIF5B | 5000 | -2620 |
| FAU | -1127 | -1637 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| UBA52 | 2067 | 260 |
tRNA processing in the mitochondrion
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 3e-04 |
| p.adjustMANOVA | 0.00118 |
| s.dist | 0.306 |
| s.low.CRP | -0.303 |
| s.high.CRP | 0.0416 |
| p.low.CRP | 0.00298 |
| p.high.CRP | 0.684 |
| Gene | low CRP | high CRP |
|---|---|---|
| MT-ATP8 | -8176 | 7306 |
| MT-TC | -7569 | 5021 |
| MT-TN | -7103 | 4345 |
| MT-TS1 | -6094 | 4713 |
| MT-RNR2 | -4826 | 4275 |
| MT-ND4L | -5984 | 3290 |
| MT-ATP6 | -5000 | 3338 |
| MT-ND5 | -2601 | 2772 |
| MT-CYB | -2505 | 365 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ELAC2 | -9406 | -5824 |
| HSD17B10 | 6214 | 6724 |
| MT-ATP6 | -5000 | 3338 |
| MT-ATP8 | -8176 | 7306 |
| MT-CO1 | 2995 | 5163 |
| MT-CO2 | 2723 | 3643 |
| MT-CO3 | 307 | 4978 |
| MT-CYB | -2505 | 365 |
| MT-ND1 | -3359 | -920 |
| MT-ND2 | -6325 | -4137 |
| MT-ND3 | 886 | 1784 |
| MT-ND4 | 641 | 3660 |
| MT-ND4L | -5984 | 3290 |
| MT-ND5 | -2601 | 2772 |
| MT-ND6 | 6472 | 6305 |
| MT-RNR1 | -4660 | -192 |
| MT-RNR2 | -4826 | 4275 |
| MT-TA | -6672 | -419 |
| MT-TC | -7569 | 5021 |
| MT-TE | -5714 | -5335 |
| MT-TF | -7110 | -3561 |
| MT-TL1 | -9034 | -5535 |
| MT-TL2 | -9109 | -5765 |
| MT-TM | -9517 | -3774 |
| MT-TN | -7103 | 4345 |
| MT-TP | -10934 | -10287 |
| MT-TS1 | -6094 | 4713 |
| MT-TV | -8649 | -6121 |
| MT-TY | -8619 | -11 |
| PRORP | 4765 | 6138 |
| TRMT10C | 7114 | -3353 |
| TRNT1 | 2475 | -5086 |
Platelet calcium homeostasis
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 0.0108 |
| p.adjustMANOVA | 0.029 |
| s.dist | 0.241 |
| s.low.CRP | -0.155 |
| s.high.CRP | 0.185 |
| p.low.CRP | 0.219 |
| p.high.CRP | 0.143 |
| Gene | low CRP | high CRP |
|---|---|---|
| STIM1 | -9782 | 6145 |
| TRPC6 | -7554 | 2174 |
| ORAI2 | -2897 | 4779 |
| ATP2B4 | -10562 | 922 |
| CALM1 | -4337 | 1051 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ATP2A1 | -4842 | -734 |
| ATP2A2 | 7987 | 8967 |
| ATP2A3 | -10436 | -1355 |
| ATP2B1 | -3461 | -5580 |
| ATP2B4 | -10562 | 922 |
| CALM1 | -4337 | 1051 |
| ITPR1 | -9755 | -3689 |
| ITPR2 | 4786 | 9335 |
| ITPR3 | -8426 | -7902 |
| ORAI1 | -8363 | -7067 |
| ORAI2 | -2897 | 4779 |
| P2RX1 | 566 | 10417 |
| P2RX4 | 9476 | 9713 |
| P2RX5 | -2226 | -755 |
| P2RX7 | 7506 | 2020 |
| SLC8A1 | 9847 | 9631 |
| SLC8A3 | 793 | -3989 |
| SRI | 8230 | 7710 |
| STIM1 | -9782 | 6145 |
| TRPC3 | -8356 | -765 |
| TRPC6 | -7554 | 2174 |
Processing of SMDT1
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.00949 |
| p.adjustMANOVA | 0.0258 |
| s.dist | 0.4 |
| s.low.CRP | 0.396 |
| s.high.CRP | 0.0568 |
| p.low.CRP | 0.00792 |
| p.high.CRP | 0.703 |
| Gene | low CRP | high CRP |
|---|---|---|
| MICU1 | 10334 | 10531 |
| MCU | 10263 | 9958 |
| PARL | 9207 | 10364 |
| YME1L1 | 7887 | 7934 |
| MICU2 | 4618 | 2705 |
| PHB2 | 4595 | 2080 |
| PMPCB | 3892 | 1819 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AFG3L2 | -2518 | -7253 |
| MCU | 10263 | 9958 |
| MCUB | 7996 | -2236 |
| MICU1 | 10334 | 10531 |
| MICU2 | 4618 | 2705 |
| MICU3 | 2919 | -7098 |
| PARL | 9207 | 10364 |
| PHB | 4244 | -2118 |
| PHB2 | 4595 | 2080 |
| PMPCA | 1173 | -6470 |
| PMPCB | 3892 | 1819 |
| SMDT1 | -1492 | -1047 |
| SPG7 | -5687 | -9286 |
| STOML2 | 1086 | -1104 |
| YME1L1 | 7887 | 7934 |
rRNA processing in the nucleus and cytosol
| metric | value |
|---|---|
| setSize | 189 |
| pMANOVA | 1.34e-19 |
| p.adjustMANOVA | 9.59e-18 |
| s.dist | 0.279 |
| s.low.CRP | 0.0661 |
| s.high.CRP | -0.271 |
| p.low.CRP | 0.117 |
| p.high.CRP | 1.3e-10 |
| Gene | low CRP | high CRP |
|---|---|---|
| RPP40 | 7453 | -8690 |
| GNL3 | 6083 | -7025 |
| RPP38 | 5051 | -7716 |
| WDR75 | 4353 | -8698 |
| NOP58 | 4347 | -8474 |
| TSR1 | 4712 | -7123 |
| MPHOSPH10 | 5952 | -4333 |
| EMG1 | 4466 | -5473 |
| RPS3A | 5865 | -3619 |
| UTP15 | 2657 | -7360 |
| EXOSC9 | 2761 | -7072 |
| RPP30 | 5972 | -3194 |
| RPS26 | 3527 | -5041 |
| NOL11 | 1925 | -8448 |
| DIMT1 | 2279 | -6842 |
| RPL18 | 3381 | -4456 |
| EXOSC5 | 1739 | -8095 |
| DDX47 | 1777 | -7672 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| BMS1 | -5936 | -8197 |
| BOP1 | -3795 | -5762 |
| BYSL | -1005 | -2393 |
| C1D | 6736 | 4014 |
| CSNK1D | -8768 | 1189 |
| CSNK1E | -9314 | -5872 |
| DCAF13 | 327 | 6103 |
| DDX21 | 9035 | 4115 |
| DDX47 | 1777 | -7672 |
| DDX49 | 3833 | 4376 |
| DDX52 | 8089 | 4089 |
| DHX37 | -7195 | -4839 |
| DIMT1 | 2279 | -6842 |
| DIS3 | 1689 | -830 |
| DKC1 | -4589 | -10307 |
| EBNA1BP2 | 5515 | -1375 |
| EMG1 | 4466 | -5473 |
| ERI1 | 5656 | 5643 |
| EXOSC1 | 2885 | 304 |
| EXOSC10 | -6650 | -5828 |
| EXOSC2 | -3961 | -8955 |
| EXOSC3 | 1418 | 2162 |
| EXOSC4 | 5868 | 7957 |
| EXOSC5 | 1739 | -8095 |
| EXOSC6 | -9351 | -7944 |
| EXOSC7 | -6315 | -5278 |
| EXOSC8 | -3547 | -9913 |
| EXOSC9 | 2761 | -7072 |
| FAU | -1127 | -1637 |
| FBL | -6170 | -7357 |
| FCF1 | 7340 | 6857 |
| FTSJ3 | -4598 | 507 |
| GAR1 | 1898 | -2266 |
| GNL3 | 6083 | -7025 |
| HEATR1 | -5578 | -8123 |
| IMP3 | -7393 | -8684 |
| IMP4 | -7848 | -9701 |
| ISG20L2 | 732 | 5116 |
| KRR1 | 375 | -5095 |
| LAS1L | -9410 | -9422 |
| LTV1 | 7672 | 3314 |
| MPHOSPH10 | 5952 | -4333 |
| MPHOSPH6 | 5285 | 7932 |
| MTREX | 4323 | 3278 |
| NAT10 | -8029 | -9599 |
| NCL | -4547 | -7597 |
| NHP2 | 4484 | -2384 |
| NIP7 | 2396 | -3614 |
| NOB1 | -6895 | -7557 |
| NOC4L | -6324 | -2308 |
| NOL11 | 1925 | -8448 |
| NOL12 | 6226 | 5817 |
| NOL6 | -7959 | -8898 |
| NOL9 | -6074 | -8704 |
| NOP10 | 8570 | 9831 |
| NOP14 | -6422 | -8870 |
| NOP2 | -4106 | -6672 |
| NOP56 | -5022 | -9989 |
| NOP58 | 4347 | -8474 |
| PDCD11 | -10108 | -7686 |
| PELP1 | -2643 | -9040 |
| PES1 | 4862 | -993 |
| PNO1 | 6437 | -1058 |
| PWP2 | 2407 | 4941 |
| RBM28 | -10189 | -7366 |
| RCL1 | 7236 | 2023 |
| RIOK1 | 5183 | 3907 |
| RIOK2 | 9357 | 84 |
| RIOK3 | 9413 | 9229 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPP14 | 6153 | 3856 |
| RPP21 | -2599 | -4355 |
| RPP25 | -6016 | -6916 |
| RPP30 | 5972 | -3194 |
| RPP38 | 5051 | -7716 |
| RPP40 | 7453 | -8690 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| RRP1 | 1558 | -5262 |
| RRP36 | -39 | 3862 |
| RRP7A | -4975 | -3024 |
| RRP9 | 72 | -8148 |
| SENP3 | 1324 | 5191 |
| SNORD3A | -9792 | 1193 |
| SNU13 | -139 | -5644 |
| TBL3 | -4163 | -4984 |
| TEX10 | -728 | -6521 |
| THUMPD1 | 48 | -9681 |
| TRMT112 | 3035 | 510 |
| TSR1 | 4712 | -7123 |
| TSR3 | -1220 | 3240 |
| UBA52 | 2067 | 260 |
| UTP11 | 8322 | 6927 |
| UTP14A | 2019 | 2472 |
| UTP14C | -713 | 1477 |
| UTP15 | 2657 | -7360 |
| UTP18 | 6514 | 7406 |
| UTP20 | -1589 | -7369 |
| UTP3 | 2595 | 699 |
| UTP4 | -736 | -9058 |
| UTP6 | 6320 | 367 |
| WDR12 | 7691 | 8132 |
| WDR18 | 3545 | -3386 |
| WDR3 | -1131 | -931 |
| WDR36 | 2502 | -1850 |
| WDR43 | 2464 | -3068 |
| WDR46 | -6771 | -6887 |
| WDR75 | 4353 | -8698 |
| XRN2 | 10201 | 10472 |
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.000117 |
| p.adjustMANOVA | 0.000501 |
| s.dist | 0.842 |
| s.low.CRP | 0.403 |
| s.high.CRP | 0.739 |
| p.low.CRP | 0.0206 |
| p.high.CRP | 2.17e-05 |
| Gene | low CRP | high CRP |
|---|---|---|
| FZD5 | 10298 | 10651 |
| CLTC | 9482 | 10359 |
| CLTA | 9206 | 9264 |
| AP2S1 | 8593 | 9630 |
| AP2M1 | 7928 | 9269 |
| AP2A2 | 5529 | 9467 |
| FZD2 | 6397 | 6508 |
| CLTB | 891 | 6664 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AP2A1 | -5326 | 9611 |
| AP2A2 | 5529 | 9467 |
| AP2B1 | -8369 | 3155 |
| AP2M1 | 7928 | 9269 |
| AP2S1 | 8593 | 9630 |
| CLTA | 9206 | 9264 |
| CLTB | 891 | 6664 |
| CLTC | 9482 | 10359 |
| FZD2 | 6397 | 6508 |
| FZD5 | 10298 | 10651 |
| ROR1 | -854 | 2172 |
SRP-dependent cotranslational protein targeting to membrane
| metric | value |
|---|---|
| setSize | 110 |
| pMANOVA | 8.81e-11 |
| p.adjustMANOVA | 1.48e-09 |
| s.dist | 0.239 |
| s.low.CRP | 0.187 |
| s.high.CRP | -0.149 |
| p.low.CRP | 0.000695 |
| p.high.CRP | 0.00694 |
| Gene | low CRP | high CRP |
|---|---|---|
| SEC11C | 4927 | -6276 |
| TRAM1 | 5957 | -3682 |
| RPS3A | 5865 | -3619 |
| RPS26 | 3527 | -5041 |
| RPL18 | 3381 | -4456 |
| RPS3 | 2486 | -5123 |
| RPL10A | 1976 | -6292 |
| RPL36AL | 5944 | -2052 |
| RPL5 | 4105 | -2796 |
| RPL4 | 4738 | -2403 |
| RPL12 | 2014 | -5298 |
| RPS25 | 2600 | -3817 |
| RPL13 | 2796 | -3228 |
| RPS13 | 5276 | -1635 |
| RPS6 | 2176 | -3737 |
| RPL22 | 4761 | -1687 |
| RPL36A | 1606 | -4363 |
| RPL7 | 5143 | -1272 |
| RPLP0 | 6333 | -1009 |
| RPL11 | 1839 | -3327 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| DDOST | 5768 | 8734 |
| FAU | -1127 | -1637 |
| RPL10 | 631 | -5696 |
| RPL10A | 1976 | -6292 |
| RPL11 | 1839 | -3327 |
| RPL12 | 2014 | -5298 |
| RPL13 | 2796 | -3228 |
| RPL13A | -1728 | -6706 |
| RPL14 | -1317 | -5766 |
| RPL15 | 5748 | 532 |
| RPL17 | 143 | -3476 |
| RPL18 | 3381 | -4456 |
| RPL18A | -1706 | -4694 |
| RPL19 | -787 | -4539 |
| RPL21 | 276 | -3918 |
| RPL22 | 4761 | -1687 |
| RPL22L1 | 7231 | -349 |
| RPL23 | 3153 | -1612 |
| RPL23A | -903 | -7885 |
| RPL24 | 1656 | -1751 |
| RPL26 | 842 | -3483 |
| RPL26L1 | 8258 | 7992 |
| RPL27 | 1376 | -417 |
| RPL27A | -1685 | -3049 |
| RPL28 | 2709 | -1855 |
| RPL29 | 1515 | -3475 |
| RPL3 | -3958 | -7454 |
| RPL30 | -2576 | -5578 |
| RPL31 | -429 | -3242 |
| RPL32 | 219 | -4702 |
| RPL34 | -1732 | -6642 |
| RPL35 | -9119 | -4134 |
| RPL35A | -112 | -2513 |
| RPL36 | -4022 | -4235 |
| RPL36A | 1606 | -4363 |
| RPL36AL | 5944 | -2052 |
| RPL37 | -6271 | -3029 |
| RPL37A | -2362 | -447 |
| RPL38 | -4515 | -3500 |
| RPL39 | 2137 | 350 |
| RPL39L | -7572 | -3974 |
| RPL4 | 4738 | -2403 |
| RPL41 | -1299 | -3511 |
| RPL5 | 4105 | -2796 |
| RPL6 | 4935 | -1237 |
| RPL7 | 5143 | -1272 |
| RPL7A | 1809 | -1927 |
| RPL8 | 1265 | -1924 |
| RPL9 | 700 | -4879 |
| RPLP0 | 6333 | -1009 |
| RPLP1 | -1197 | 916 |
| RPLP2 | -4847 | -5802 |
| RPN1 | 8456 | 8842 |
| RPN2 | 7659 | 7805 |
| RPS10 | -489 | -4974 |
| RPS11 | -2316 | -5641 |
| RPS12 | -4797 | -7620 |
| RPS13 | 5276 | -1635 |
| RPS14 | -4624 | -5393 |
| RPS15 | -1754 | -3299 |
| RPS15A | 1269 | -4048 |
| RPS16 | -2078 | -6063 |
| RPS17 | -5045 | -3169 |
| RPS18 | -7322 | -6605 |
| RPS19 | -2989 | -7057 |
| RPS2 | 1634 | -3308 |
| RPS20 | -2911 | -6018 |
| RPS21 | -1933 | -3896 |
| RPS23 | 772 | -4150 |
| RPS24 | 6586 | 1001 |
| RPS25 | 2600 | -3817 |
| RPS26 | 3527 | -5041 |
| RPS27 | -7168 | -6878 |
| RPS27A | -1868 | -5386 |
| RPS27L | 7604 | 4230 |
| RPS28 | -2921 | -3626 |
| RPS29 | -6817 | -4617 |
| RPS3 | 2486 | -5123 |
| RPS3A | 5865 | -3619 |
| RPS4X | -677 | -7632 |
| RPS4Y1 | 3815 | 574 |
| RPS5 | -1017 | -5500 |
| RPS6 | 2176 | -3737 |
| RPS7 | 1946 | -2271 |
| RPS8 | 3760 | -769 |
| RPS9 | 7673 | 4928 |
| RPSA | -3597 | -5016 |
| SEC11A | 7834 | 9453 |
| SEC11C | 4927 | -6276 |
| SEC61A1 | 8546 | 7506 |
| SEC61A2 | -8294 | -8164 |
| SEC61B | 9260 | 8673 |
| SEC61G | 8791 | 5259 |
| SPCS1 | 7553 | 4977 |
| SPCS2 | 7508 | 4451 |
| SPCS3 | 7891 | 5004 |
| SRP14 | 5097 | 7759 |
| SRP19 | 8759 | 6276 |
| SRP54 | 9899 | 8393 |
| SRP68 | 4756 | 4519 |
| SRP72 | 4576 | 1760 |
| SRP9 | 9330 | 5662 |
| SRPRA | -235 | 6430 |
| SRPRB | -254 | -8543 |
| SSR1 | 9162 | 7637 |
| SSR2 | 7502 | 2833 |
| SSR3 | 8865 | 7729 |
| SSR4 | 4508 | 2346 |
| TRAM1 | 5957 | -3682 |
| UBA52 | 2067 | 260 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] parallel stats4 stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] pkgload_1.2.0 GGally_2.1.1
## [3] beeswarm_0.3.1 gtools_3.8.2
## [5] echarts4r_0.4.0 topconfects_1.6.0
## [7] limma_3.46.0 eulerr_6.1.0
## [9] mitch_1.2.2 MASS_7.3-53.1
## [11] fgsea_1.16.0 gplots_3.1.1
## [13] DESeq2_1.30.0 SummarizedExperiment_1.20.0
## [15] Biobase_2.50.0 MatrixGenerics_1.2.0
## [17] matrixStats_0.58.0 GenomicRanges_1.42.0
## [19] GenomeInfoDb_1.26.0 IRanges_2.24.0
## [21] S4Vectors_0.28.0 BiocGenerics_0.36.0
## [23] reshape2_1.4.4 forcats_0.5.1
## [25] stringr_1.4.0 dplyr_1.0.5
## [27] purrr_0.3.4 readr_1.4.0
## [29] tidyr_1.1.3 tibble_3.1.0
## [31] ggplot2_3.3.3 tidyverse_1.3.0
## [33] zoo_1.8-9
##
## loaded via a namespace (and not attached):
## [1] colorspace_2.0-0 ellipsis_0.3.1 rprojroot_2.0.2
## [4] XVector_0.30.0 fs_1.5.0 rstudioapi_0.13
## [7] farver_2.1.0 bit64_4.0.5 AnnotationDbi_1.52.0
## [10] fansi_0.4.2 lubridate_1.7.10 xml2_1.3.2
## [13] splines_4.0.3 cachem_1.0.4 geneplotter_1.68.0
## [16] knitr_1.31 polyclip_1.10-0 jsonlite_1.7.2
## [19] broom_0.7.5 annotate_1.68.0 dbplyr_2.1.0
## [22] shiny_1.6.0 compiler_4.0.3 httr_1.4.2
## [25] backports_1.2.1 assertthat_0.2.1 Matrix_1.3-2
## [28] fastmap_1.1.0 cli_2.3.1 later_1.1.0.1
## [31] htmltools_0.5.1.1 tools_4.0.3 gtable_0.3.0
## [34] glue_1.4.2 GenomeInfoDbData_1.2.4 fastmatch_1.1-0
## [37] Rcpp_1.0.6 cellranger_1.1.0 jquerylib_0.1.3
## [40] vctrs_0.3.6 polylabelr_0.2.0 xfun_0.22
## [43] ps_1.6.0 testthat_3.0.2 rvest_1.0.0
## [46] mime_0.10 lifecycle_1.0.0 XML_3.99-0.6
## [49] zlibbioc_1.36.0 scales_1.1.1 promises_1.2.0.1
## [52] hms_1.0.0 RColorBrewer_1.1-2 yaml_2.2.1
## [55] memoise_2.0.0 gridExtra_2.3 sass_0.3.1
## [58] reshape_0.8.8 stringi_1.5.3 RSQLite_2.2.4
## [61] highr_0.8 genefilter_1.72.0 desc_1.3.0
## [64] caTools_1.18.1 BiocParallel_1.24.1 rlang_0.4.10
## [67] pkgconfig_2.0.3 bitops_1.0-6 evaluate_0.14
## [70] lattice_0.20-41 labeling_0.4.2 htmlwidgets_1.5.3
## [73] bit_4.0.4 tidyselect_1.1.0 plyr_1.8.6
## [76] magrittr_2.0.1 R6_2.5.0 generics_0.1.0
## [79] DelayedArray_0.16.0 DBI_1.1.1 pillar_1.5.1
## [82] haven_2.3.1 withr_2.4.1 survival_3.2-10
## [85] RCurl_1.98-1.3 modelr_0.1.8 crayon_1.4.1
## [88] KernSmooth_2.23-18 utf8_1.2.1 rmarkdown_2.7
## [91] locfit_1.5-9.4 grid_4.0.3 readxl_1.3.1
## [94] data.table_1.14.0 blob_1.2.1 reprex_1.0.0
## [97] digest_0.6.27 xtable_1.8-4 httpuv_1.5.5
## [100] munsell_0.5.0 bslib_0.2.4END of report