date generated: 2021-04-20

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                   x
## A1BG      2.6192564
## A1BG-AS1  0.5230655
## A1CF      0.5526173
## A2M      -3.3389616
## A2M-AS1  -3.1580711
## A2ML1    -0.3535245

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genesets 2408
num_genes_in_profile 21907
duplicated_genes_present 0
num_profile_genes_in_sets 8450
num_profile_genes_not_in_sets 13457

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2408
num_genesets_excluded 1042
num_genesets_included 1366

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 100 gene sets

set setSize pANOVA s.dist p.adjustANOVA
IRAK4 deficiency (TLR2/4) 10 8.37e-07 0.899 1.05e-05
MyD88 deficiency (TLR2/4) 10 8.37e-07 0.899 1.05e-05
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.46e-06 0.785 2.63e-05
alpha-linolenic acid (ALA) metabolism 12 2.46e-06 0.785 2.63e-05
Regulation of TLR by endogenous ligand 11 1.93e-05 0.744 1.45e-04
Translocation of ZAP-70 to Immunological synapse 24 2.81e-10 -0.744 8.34e-09
Hyaluronan uptake and degradation 12 8.85e-06 0.741 7.24e-05
Uptake and function of anthrax toxins 10 1.14e-04 0.705 6.52e-04
Erythrocytes take up carbon dioxide and release oxygen 11 9.46e-05 0.680 5.53e-04
O2/CO2 exchange in erythrocytes 11 9.46e-05 0.680 5.53e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.17e-04 0.671 6.58e-04
p130Cas linkage to MAPK signaling for integrins 11 1.32e-04 0.665 7.22e-04
Advanced glycosylation endproduct receptor signaling 12 9.48e-05 0.651 5.53e-04
Unwinding of DNA 12 1.32e-04 -0.637 7.22e-04
RNA Polymerase I Promoter Opening 19 3.29e-06 0.616 3.28e-05
RHO GTPases Activate WASPs and WAVEs 35 4.57e-10 0.609 1.33e-08
ROS and RNS production in phagocytes 31 8.23e-09 0.598 1.76e-07
Neutrophil degranulation 457 0.00e+00 0.587 2.00e-100
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 4.97e-04 0.580 2.29e-03
PD-1 signaling 28 1.11e-07 -0.579 1.87e-06
Insulin receptor recycling 21 6.43e-06 0.569 5.70e-05
Dissolution of Fibrin Clot 12 6.70e-04 0.567 2.93e-03
Retrograde neurotrophin signalling 12 6.74e-04 0.567 2.93e-03
Signaling by Leptin 10 1.97e-03 0.565 7.07e-03
COPI-independent Golgi-to-ER retrograde traffic 33 2.11e-08 0.563 4.24e-07
Detoxification of Reactive Oxygen Species 32 3.64e-08 0.562 6.90e-07
RHO GTPases Activate NADPH Oxidases 21 9.01e-06 0.560 7.33e-05
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 5.15e-04 0.556 2.35e-03
Platelet sensitization by LDL 16 1.28e-04 0.553 7.08e-04
Hyaluronan metabolism 15 2.20e-04 0.551 1.13e-03
Golgi Cisternae Pericentriolar Stack Reorganization 14 3.65e-04 0.550 1.75e-03
RHO GTPases Activate ROCKs 18 6.85e-05 0.542 4.20e-04
Phosphorylation of CD3 and TCR zeta chains 27 1.38e-06 -0.537 1.62e-05
Diseases associated with the TLR signaling cascade 23 8.79e-06 0.535 7.23e-05
Diseases of Immune System 23 8.79e-06 0.535 7.23e-05
IRAK1 recruits IKK complex 10 3.46e-03 0.534 1.14e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 3.46e-03 0.534 1.14e-02
MET activates RAP1 and RAC1 10 3.66e-03 0.531 1.19e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 3.85e-03 0.528 1.23e-02
Negative regulation of MET activity 18 1.11e-04 0.526 6.39e-04
Budding and maturation of HIV virion 26 3.45e-06 0.526 3.41e-05
InlB-mediated entry of Listeria monocytogenes into host cell 12 1.61e-03 0.526 6.05e-03
DNA strand elongation 32 3.21e-07 -0.522 4.92e-06
Cargo concentration in the ER 30 7.76e-07 0.521 1.03e-05
Endosomal Sorting Complex Required For Transport (ESCRT) 29 1.25e-06 0.520 1.49e-05
DNA methylation 20 6.16e-05 0.517 3.82e-04
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 4.10e-05 0.517 2.74e-04
Neurodegenerative Diseases 21 4.10e-05 0.517 2.74e-04
MAP2K and MAPK activation 34 1.81e-07 0.517 2.91e-06
VLDLR internalisation and degradation 12 2.16e-03 0.511 7.59e-03
Transferrin endocytosis and recycling 26 6.92e-06 0.509 5.98e-05
EPHB-mediated forward signaling 32 7.98e-07 0.504 1.03e-05
Gap junction trafficking 14 1.16e-03 0.501 4.58e-03
Platelet Adhesion to exposed collagen 13 1.76e-03 0.501 6.49e-03
Signaling by high-kinase activity BRAF mutants 31 1.54e-06 0.499 1.77e-05
Smooth Muscle Contraction 31 1.87e-06 0.495 2.10e-05
Pentose phosphate pathway 13 2.26e-03 0.489 7.94e-03
RHO GTPases activate PAKs 20 1.70e-04 0.486 9.02e-04
RHO GTPases activate PKNs 48 6.95e-09 0.483 1.56e-07
Amyloid fiber formation 51 2.44e-09 0.483 5.64e-08
Activation of the pre-replicative complex 32 2.43e-06 -0.481 2.63e-05
SHC1 events in EGFR signaling 12 3.92e-03 0.481 1.25e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 4.12e-03 0.478 1.30e-02
Diseases of hemostasis 12 4.12e-03 0.478 1.30e-02
GRB2 events in EGFR signaling 11 6.02e-03 0.478 1.77e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 6.19e-03 0.477 1.81e-02
Platelet Aggregation (Plug Formation) 28 1.27e-05 0.477 1.00e-04
Spry regulation of FGF signaling 16 9.96e-04 0.475 4.05e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 1.29e-04 0.472 7.08e-04
Signaling by RAF1 mutants 34 1.94e-06 0.472 2.16e-05
Josephin domain DUBs 10 9.89e-03 0.471 2.61e-02
GAB1 signalosome 15 1.59e-03 0.471 5.97e-03
Trafficking of GluR2-containing AMPA receptors 12 4.79e-03 0.470 1.48e-02
Generation of second messenger molecules 38 7.20e-07 -0.464 9.74e-06
EGFR downregulation 27 3.34e-05 0.461 2.28e-04
Response of Mtb to phagocytosis 22 1.91e-04 0.459 9.90e-04
Antimicrobial peptides 33 4.93e-06 0.459 4.52e-05
The NLRP3 inflammasome 15 2.13e-03 0.458 7.51e-03
Integrin signaling 22 2.08e-04 0.457 1.08e-03
Response to elevated platelet cytosolic Ca2+ 110 1.25e-16 0.457 1.22e-14
activated TAK1 mediates p38 MAPK activation 19 5.78e-04 0.456 2.60e-03
Mucopolysaccharidoses 11 8.83e-03 0.456 2.41e-02
Platelet degranulation 106 5.81e-16 0.455 5.29e-14
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 2.30e-03 0.455 8.05e-03
Lagging Strand Synthesis 20 4.63e-04 -0.452 2.15e-03
Prolonged ERK activation events 13 4.76e-03 0.452 1.47e-02
Infection with Mycobacterium tuberculosis 26 7.20e-05 0.450 4.39e-04
WNT5A-dependent internalization of FZD4 13 5.02e-03 0.449 1.53e-02
Packaging Of Telomere Ends 20 5.17e-04 0.448 2.35e-03
ATF6 (ATF6-alpha) activates chaperone genes 10 1.44e-02 0.447 3.52e-02
Membrane binding and targetting of GAG proteins 13 5.40e-03 0.446 1.62e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 5.40e-03 0.446 1.62e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 1.57e-04 -0.446 8.44e-04
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 1.09e-02 0.443 2.79e-02
Signal amplification 28 5.41e-05 0.441 3.45e-04
Biotin transport and metabolism 11 1.16e-02 -0.440 2.91e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 3.03e-13 0.440 1.53e-11
Toll Like Receptor 2 (TLR2) Cascade 92 3.03e-13 0.440 1.53e-11
Toll Like Receptor TLR1:TLR2 Cascade 92 3.03e-13 0.440 1.53e-11
Toll Like Receptor TLR6:TLR2 Cascade 92 3.03e-13 0.440 1.53e-11


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
IRAK4 deficiency (TLR2/4) 10 8.37e-07 8.99e-01 1.05e-05
MyD88 deficiency (TLR2/4) 10 8.37e-07 8.99e-01 1.05e-05
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.46e-06 7.85e-01 2.63e-05
alpha-linolenic acid (ALA) metabolism 12 2.46e-06 7.85e-01 2.63e-05
Regulation of TLR by endogenous ligand 11 1.93e-05 7.44e-01 1.45e-04
Translocation of ZAP-70 to Immunological synapse 24 2.81e-10 -7.44e-01 8.34e-09
Hyaluronan uptake and degradation 12 8.85e-06 7.41e-01 7.24e-05
Uptake and function of anthrax toxins 10 1.14e-04 7.05e-01 6.52e-04
Erythrocytes take up carbon dioxide and release oxygen 11 9.46e-05 6.80e-01 5.53e-04
O2/CO2 exchange in erythrocytes 11 9.46e-05 6.80e-01 5.53e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.17e-04 6.71e-01 6.58e-04
p130Cas linkage to MAPK signaling for integrins 11 1.32e-04 6.65e-01 7.22e-04
Advanced glycosylation endproduct receptor signaling 12 9.48e-05 6.51e-01 5.53e-04
Unwinding of DNA 12 1.32e-04 -6.37e-01 7.22e-04
RNA Polymerase I Promoter Opening 19 3.29e-06 6.16e-01 3.28e-05
RHO GTPases Activate WASPs and WAVEs 35 4.57e-10 6.09e-01 1.33e-08
ROS and RNS production in phagocytes 31 8.23e-09 5.98e-01 1.76e-07
Neutrophil degranulation 457 0.00e+00 5.87e-01 2.00e-100
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 4.97e-04 5.80e-01 2.29e-03
PD-1 signaling 28 1.11e-07 -5.79e-01 1.87e-06
Insulin receptor recycling 21 6.43e-06 5.69e-01 5.70e-05
Dissolution of Fibrin Clot 12 6.70e-04 5.67e-01 2.93e-03
Retrograde neurotrophin signalling 12 6.74e-04 5.67e-01 2.93e-03
Signaling by Leptin 10 1.97e-03 5.65e-01 7.07e-03
COPI-independent Golgi-to-ER retrograde traffic 33 2.11e-08 5.63e-01 4.24e-07
Detoxification of Reactive Oxygen Species 32 3.64e-08 5.62e-01 6.90e-07
RHO GTPases Activate NADPH Oxidases 21 9.01e-06 5.60e-01 7.33e-05
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 5.15e-04 5.56e-01 2.35e-03
Platelet sensitization by LDL 16 1.28e-04 5.53e-01 7.08e-04
Hyaluronan metabolism 15 2.20e-04 5.51e-01 1.13e-03
Golgi Cisternae Pericentriolar Stack Reorganization 14 3.65e-04 5.50e-01 1.75e-03
RHO GTPases Activate ROCKs 18 6.85e-05 5.42e-01 4.20e-04
Phosphorylation of CD3 and TCR zeta chains 27 1.38e-06 -5.37e-01 1.62e-05
Diseases associated with the TLR signaling cascade 23 8.79e-06 5.35e-01 7.23e-05
Diseases of Immune System 23 8.79e-06 5.35e-01 7.23e-05
IRAK1 recruits IKK complex 10 3.46e-03 5.34e-01 1.14e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 3.46e-03 5.34e-01 1.14e-02
MET activates RAP1 and RAC1 10 3.66e-03 5.31e-01 1.19e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 3.85e-03 5.28e-01 1.23e-02
Negative regulation of MET activity 18 1.11e-04 5.26e-01 6.39e-04
Budding and maturation of HIV virion 26 3.45e-06 5.26e-01 3.41e-05
InlB-mediated entry of Listeria monocytogenes into host cell 12 1.61e-03 5.26e-01 6.05e-03
DNA strand elongation 32 3.21e-07 -5.22e-01 4.92e-06
Cargo concentration in the ER 30 7.76e-07 5.21e-01 1.03e-05
Endosomal Sorting Complex Required For Transport (ESCRT) 29 1.25e-06 5.20e-01 1.49e-05
DNA methylation 20 6.16e-05 5.17e-01 3.82e-04
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 4.10e-05 5.17e-01 2.74e-04
Neurodegenerative Diseases 21 4.10e-05 5.17e-01 2.74e-04
MAP2K and MAPK activation 34 1.81e-07 5.17e-01 2.91e-06
VLDLR internalisation and degradation 12 2.16e-03 5.11e-01 7.59e-03
Transferrin endocytosis and recycling 26 6.92e-06 5.09e-01 5.98e-05
EPHB-mediated forward signaling 32 7.98e-07 5.04e-01 1.03e-05
Gap junction trafficking 14 1.16e-03 5.01e-01 4.58e-03
Platelet Adhesion to exposed collagen 13 1.76e-03 5.01e-01 6.49e-03
Signaling by high-kinase activity BRAF mutants 31 1.54e-06 4.99e-01 1.77e-05
Smooth Muscle Contraction 31 1.87e-06 4.95e-01 2.10e-05
Pentose phosphate pathway 13 2.26e-03 4.89e-01 7.94e-03
RHO GTPases activate PAKs 20 1.70e-04 4.86e-01 9.02e-04
RHO GTPases activate PKNs 48 6.95e-09 4.83e-01 1.56e-07
Amyloid fiber formation 51 2.44e-09 4.83e-01 5.64e-08
Activation of the pre-replicative complex 32 2.43e-06 -4.81e-01 2.63e-05
SHC1 events in EGFR signaling 12 3.92e-03 4.81e-01 1.25e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 4.12e-03 4.78e-01 1.30e-02
Diseases of hemostasis 12 4.12e-03 4.78e-01 1.30e-02
GRB2 events in EGFR signaling 11 6.02e-03 4.78e-01 1.77e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 6.19e-03 4.77e-01 1.81e-02
Platelet Aggregation (Plug Formation) 28 1.27e-05 4.77e-01 1.00e-04
Spry regulation of FGF signaling 16 9.96e-04 4.75e-01 4.05e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 1.29e-04 4.72e-01 7.08e-04
Signaling by RAF1 mutants 34 1.94e-06 4.72e-01 2.16e-05
Josephin domain DUBs 10 9.89e-03 4.71e-01 2.61e-02
GAB1 signalosome 15 1.59e-03 4.71e-01 5.97e-03
Trafficking of GluR2-containing AMPA receptors 12 4.79e-03 4.70e-01 1.48e-02
Generation of second messenger molecules 38 7.20e-07 -4.64e-01 9.74e-06
EGFR downregulation 27 3.34e-05 4.61e-01 2.28e-04
Response of Mtb to phagocytosis 22 1.91e-04 4.59e-01 9.90e-04
Antimicrobial peptides 33 4.93e-06 4.59e-01 4.52e-05
The NLRP3 inflammasome 15 2.13e-03 4.58e-01 7.51e-03
Integrin signaling 22 2.08e-04 4.57e-01 1.08e-03
Response to elevated platelet cytosolic Ca2+ 110 1.25e-16 4.57e-01 1.22e-14
activated TAK1 mediates p38 MAPK activation 19 5.78e-04 4.56e-01 2.60e-03
Mucopolysaccharidoses 11 8.83e-03 4.56e-01 2.41e-02
Platelet degranulation 106 5.81e-16 4.55e-01 5.29e-14
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 2.30e-03 4.55e-01 8.05e-03
Lagging Strand Synthesis 20 4.63e-04 -4.52e-01 2.15e-03
Prolonged ERK activation events 13 4.76e-03 4.52e-01 1.47e-02
Infection with Mycobacterium tuberculosis 26 7.20e-05 4.50e-01 4.39e-04
WNT5A-dependent internalization of FZD4 13 5.02e-03 4.49e-01 1.53e-02
Packaging Of Telomere Ends 20 5.17e-04 4.48e-01 2.35e-03
ATF6 (ATF6-alpha) activates chaperone genes 10 1.44e-02 4.47e-01 3.52e-02
Membrane binding and targetting of GAG proteins 13 5.40e-03 4.46e-01 1.62e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 5.40e-03 4.46e-01 1.62e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 1.57e-04 -4.46e-01 8.44e-04
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 1.09e-02 4.43e-01 2.79e-02
Signal amplification 28 5.41e-05 4.41e-01 3.45e-04
Biotin transport and metabolism 11 1.16e-02 -4.40e-01 2.91e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 3.03e-13 4.40e-01 1.53e-11
Toll Like Receptor 2 (TLR2) Cascade 92 3.03e-13 4.40e-01 1.53e-11
Toll Like Receptor TLR1:TLR2 Cascade 92 3.03e-13 4.40e-01 1.53e-11
Toll Like Receptor TLR6:TLR2 Cascade 92 3.03e-13 4.40e-01 1.53e-11
Signal transduction by L1 20 6.81e-04 4.39e-01 2.95e-03
Suppression of phagosomal maturation 12 8.51e-03 4.39e-01 2.34e-02
Alpha-protein kinase 1 signaling pathway 11 1.19e-02 4.38e-01 2.98e-02
RHO GTPases activate IQGAPs 11 1.26e-02 4.34e-01 3.13e-02
ERKs are inactivated 13 6.71e-03 4.34e-01 1.93e-02
Paradoxical activation of RAF signaling by kinase inactive BRAF 38 3.90e-06 4.33e-01 3.65e-05
Signaling by RAS mutants 38 3.90e-06 4.33e-01 3.65e-05
Signaling by moderate kinase activity BRAF mutants 38 3.90e-06 4.33e-01 3.65e-05
Signaling downstream of RAS mutants 38 3.90e-06 4.33e-01 3.65e-05
Sealing of the nuclear envelope (NE) by ESCRT-III 25 1.86e-04 4.32e-01 9.72e-04
Processive synthesis on the lagging strand 15 3.88e-03 -4.31e-01 1.24e-02
HDR through MMEJ (alt-NHEJ) 10 1.89e-02 -4.29e-01 4.37e-02
AKT phosphorylates targets in the cytosol 14 5.54e-03 4.28e-01 1.65e-02
Formation of ATP by chemiosmotic coupling 18 1.67e-03 4.28e-01 6.23e-03
Recycling pathway of L1 26 1.68e-04 4.26e-01 8.92e-04
Erythropoietin activates RAS 13 8.13e-03 4.24e-01 2.26e-02
Late endosomal microautophagy 30 6.00e-05 4.23e-01 3.78e-04
Butyrophilin (BTN) family interactions 10 2.05e-02 -4.23e-01 4.67e-02
Activation of ATR in response to replication stress 37 8.43e-06 -4.23e-01 7.06e-05
Interleukin-1 signaling 98 5.37e-13 4.22e-01 2.45e-11
Growth hormone receptor signaling 20 1.10e-03 4.21e-01 4.41e-03
PCNA-Dependent Long Patch Base Excision Repair 21 8.48e-04 -4.21e-01 3.59e-03
Transcriptional regulation of granulopoiesis 46 8.63e-07 4.19e-01 1.07e-05
Assembly Of The HIV Virion 15 5.09e-03 4.18e-01 1.54e-02
Regulated proteolysis of p75NTR 11 1.65e-02 4.18e-01 3.92e-02
ATF6 (ATF6-alpha) activates chaperones 12 1.23e-02 4.17e-01 3.07e-02
Glycogen breakdown (glycogenolysis) 13 1.01e-02 4.12e-01 2.65e-02
Pre-NOTCH Processing in Golgi 18 2.51e-03 4.11e-01 8.75e-03
HuR (ELAVL1) binds and stabilizes mRNA 10 2.45e-02 4.11e-01 5.44e-02
SUMOylation of immune response proteins 11 1.84e-02 4.11e-01 4.27e-02
Gastrin-CREB signalling pathway via PKC and MAPK 14 7.84e-03 4.10e-01 2.20e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 87 3.99e-11 4.09e-01 1.36e-09
ERK/MAPK targets 22 8.93e-04 4.09e-01 3.71e-03
Notch-HLH transcription pathway 28 1.86e-04 4.08e-01 9.71e-04
Signal regulatory protein family interactions 12 1.44e-02 4.08e-01 3.52e-02
ADP signalling through P2Y purinoceptor 1 21 1.25e-03 4.07e-01 4.82e-03
Lysosome Vesicle Biogenesis 32 7.32e-05 4.05e-01 4.44e-04
HSP90 chaperone cycle for steroid hormone receptors (SHR) 36 2.62e-05 4.05e-01 1.86e-04
Glycogen synthesis 13 1.16e-02 4.04e-01 2.92e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade 89 4.41e-11 4.04e-01 1.47e-09
Heme degradation 10 2.73e-02 4.03e-01 5.97e-02
DARPP-32 events 22 1.08e-03 4.02e-01 4.34e-03
Signalling to ERKs 32 8.47e-05 4.01e-01 5.01e-04
Interleukin-6 signaling 10 2.81e-02 4.01e-01 6.11e-02
Inflammasomes 20 1.92e-03 4.01e-01 6.90e-03
Toll Like Receptor 4 (TLR4) Cascade 121 3.21e-14 3.99e-01 2.09e-12
Removal of the Flap Intermediate 14 9.82e-03 -3.99e-01 2.60e-02
mTORC1-mediated signalling 24 7.53e-04 3.97e-01 3.25e-03
MyD88 dependent cascade initiated on endosome 88 1.16e-10 3.97e-01 3.77e-09
MyD88 cascade initiated on plasma membrane 82 5.31e-10 3.97e-01 1.39e-08
Toll Like Receptor 10 (TLR10) Cascade 82 5.31e-10 3.97e-01 1.39e-08
Toll Like Receptor 5 (TLR5) Cascade 82 5.31e-10 3.97e-01 1.39e-08
rRNA modification in the nucleus and cytosol 59 1.39e-07 -3.96e-01 2.32e-06
Regulation of IFNG signaling 14 1.04e-02 3.96e-01 2.71e-02
Collagen degradation 28 3.05e-04 3.94e-01 1.50e-03
COPI-mediated anterograde transport 78 1.90e-09 3.93e-01 4.72e-08
Antigen processing-Cross presentation 98 1.88e-11 3.92e-01 6.76e-10
Metabolism of Angiotensinogen to Angiotensins 11 2.43e-02 3.92e-01 5.40e-02
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 2.11e-04 3.91e-01 1.09e-03
Signaling by BRAF and RAF fusions 57 3.30e-07 3.91e-01 4.99e-06
RHO GTPases activate KTN1 11 2.49e-02 3.91e-01 5.50e-02
Activation of the AP-1 family of transcription factors 10 3.25e-02 3.90e-01 6.85e-02
COPII-mediated vesicle transport 65 5.29e-08 3.90e-01 9.56e-07
EPH-Ephrin signaling 79 2.31e-09 3.89e-01 5.45e-08
Translation of Replicase and Assembly of the Replication Transcription Complex 12 1.98e-02 3.88e-01 4.56e-02
Energy dependent regulation of mTOR by LKB1-AMPK 27 5.03e-04 3.87e-01 2.31e-03
Telomere C-strand (Lagging Strand) Synthesis 34 9.64e-05 -3.86e-01 5.60e-04
Formation of apoptosome 11 2.75e-02 3.84e-01 5.98e-02
Regulation of the apoptosome activity 11 2.75e-02 3.84e-01 5.98e-02
Toll-like Receptor Cascades 143 2.29e-15 3.84e-01 1.96e-13
Toll Like Receptor 9 (TLR9) Cascade 92 2.03e-10 3.83e-01 6.16e-09
LDL clearance 18 5.19e-03 3.81e-01 1.57e-02
Sema4D in semaphorin signaling 22 2.00e-03 3.80e-01 7.17e-03
Apoptosis induced DNA fragmentation 10 3.79e-02 3.79e-01 7.73e-02
Cross-presentation of soluble exogenous antigens (endosomes) 48 5.62e-06 3.79e-01 5.08e-05
Frs2-mediated activation 11 3.00e-02 3.78e-01 6.43e-02
Signaling by Erythropoietin 24 1.35e-03 3.78e-01 5.18e-03
ADP signalling through P2Y purinoceptor 12 18 5.56e-03 3.77e-01 1.65e-02
G-protein beta:gamma signalling 29 4.44e-04 3.77e-01 2.08e-03
Sema4D induced cell migration and growth-cone collapse 19 4.48e-03 3.77e-01 1.40e-02
Iron uptake and transport 52 2.62e-06 3.77e-01 2.72e-05
Cellular response to hypoxia 72 3.43e-08 3.76e-01 6.61e-07
Thromboxane signalling through TP receptor 20 3.68e-03 3.75e-01 1.19e-02
Formation of the cornified envelope 21 3.06e-03 3.73e-01 1.02e-02
ER to Golgi Anterograde Transport 129 2.87e-13 3.72e-01 1.53e-11
trans-Golgi Network Vesicle Budding 69 9.29e-08 3.72e-01 1.61e-06
MTOR signalling 39 6.11e-05 3.71e-01 3.81e-04
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 54 2.48e-06 3.70e-01 2.63e-05
Signaling by NTRK1 (TRKA) 101 1.31e-10 3.70e-01 4.07e-09
RHO GTPases activate CIT 18 6.61e-03 3.70e-01 1.91e-02
Response of EIF2AK1 (HRI) to heme deficiency 14 1.68e-02 3.69e-01 4.00e-02
Gap junction trafficking and regulation 16 1.08e-02 3.68e-01 2.76e-02
Golgi Associated Vesicle Biogenesis 55 2.33e-06 3.68e-01 2.55e-05
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 2.81e-03 3.68e-01 9.49e-03
Regulation of ornithine decarboxylase (ODC) 50 6.72e-06 3.68e-01 5.89e-05
Cell-extracellular matrix interactions 14 1.73e-02 3.68e-01 4.06e-02
MAP kinase activation 63 4.52e-07 3.67e-01 6.44e-06
Innate Immune System 967 5.85e-84 3.67e-01 3.99e-81
Signaling by MET 61 7.13e-07 3.67e-01 9.74e-06
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.11e-02 3.67e-01 2.83e-02
Calnexin/calreticulin cycle 26 1.22e-03 3.66e-01 4.75e-03
RAF activation 32 3.35e-04 3.66e-01 1.64e-03
Signaling by NTRKs 116 9.74e-12 3.66e-01 3.69e-10
Diseases of DNA repair 10 4.55e-02 -3.65e-01 9.04e-02
Beta-catenin phosphorylation cascade 17 9.11e-03 3.65e-01 2.46e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 1.15e-02 3.65e-01 2.90e-02
Leading Strand Synthesis 14 1.83e-02 -3.64e-01 4.27e-02
Polymerase switching 14 1.83e-02 -3.64e-01 4.27e-02
Platelet activation, signaling and aggregation 221 1.35e-20 3.63e-01 2.05e-18
Endogenous sterols 17 1.00e-02 3.61e-01 2.64e-02
Telomere C-strand synthesis initiation 13 2.45e-02 -3.60e-01 5.44e-02
G beta:gamma signalling through CDC42 17 1.02e-02 3.60e-01 2.67e-02
Cell recruitment (pro-inflammatory response) 22 3.47e-03 3.60e-01 1.14e-02
Purinergic signaling in leishmaniasis infection 22 3.47e-03 3.60e-01 1.14e-02
HDACs deacetylate histones 47 2.04e-05 3.59e-01 1.51e-04
Regulation of activated PAK-2p34 by proteasome mediated degradation 49 1.37e-05 3.59e-01 1.05e-04
Glycogen metabolism 23 2.91e-03 3.59e-01 9.78e-03
Clathrin-mediated endocytosis 127 3.15e-12 3.58e-01 1.30e-10
IKK complex recruitment mediated by RIP1 23 2.99e-03 3.58e-01 9.98e-03
GP1b-IX-V activation signalling 10 5.04e-02 3.57e-01 9.86e-02
Pexophagy 11 4.02e-02 3.57e-01 8.13e-02
RAB geranylgeranylation 61 1.46e-06 3.57e-01 1.69e-05
MET activates RAS signaling 10 5.12e-02 3.56e-01 1.00e-01
Nucleobase biosynthesis 13 2.64e-02 -3.56e-01 5.80e-02
ER-Phagosome pathway 83 2.17e-08 3.55e-01 4.30e-07
Thrombin signalling through proteinase activated receptors (PARs) 27 1.42e-03 3.55e-01 5.41e-03
Post-translational protein phosphorylation 70 2.94e-07 3.54e-01 4.62e-06
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 65 8.07e-07 3.54e-01 1.03e-05
Interleukin-1 family signaling 125 8.55e-12 3.53e-01 3.34e-10
Negative regulation of NOTCH4 signaling 54 7.02e-06 3.53e-01 6.03e-05
Fanconi Anemia Pathway 36 2.43e-04 -3.53e-01 1.24e-03
Cleavage of the damaged purine 24 2.75e-03 3.53e-01 9.31e-03
Depurination 24 2.75e-03 3.53e-01 9.31e-03
Recognition and association of DNA glycosylase with site containing an affected purine 24 2.75e-03 3.53e-01 9.31e-03
Syndecan interactions 19 7.70e-03 3.53e-01 2.17e-02
Homologous DNA Pairing and Strand Exchange 42 7.63e-05 -3.53e-01 4.61e-04
Pre-NOTCH Transcription and Translation 49 1.95e-05 3.53e-01 1.46e-04
Defective CFTR causes cystic fibrosis 60 2.57e-06 3.51e-01 2.71e-05
Hh mutants abrogate ligand secretion 55 6.85e-06 3.51e-01 5.96e-05
MAPK targets/ Nuclear events mediated by MAP kinases 31 7.33e-04 3.50e-01 3.17e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA 54 8.71e-06 3.50e-01 7.23e-05
Pre-NOTCH Expression and Processing 65 1.18e-06 3.48e-01 1.43e-05
Resolution of Abasic Sites (AP sites) 37 2.48e-04 -3.48e-01 1.25e-03
PKA activation in glucagon signalling 14 2.47e-02 3.47e-01 5.46e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs 83 5.32e-08 3.45e-01 9.56e-07
Pyrimidine salvage 10 5.91e-02 3.45e-01 1.12e-01
Signaling by EGFR in Cancer 23 4.22e-03 3.45e-01 1.33e-02
Inhibition of DNA recombination at telomere 35 4.21e-04 3.44e-01 1.98e-03
Degradation of DVL 55 1.03e-05 3.44e-01 8.34e-05
Hedgehog ligand biogenesis 59 5.69e-06 3.41e-01 5.11e-05
G beta:gamma signalling through PLC beta 17 1.48e-02 3.41e-01 3.61e-02
Vif-mediated degradation of APOBEC3G 53 1.73e-05 3.41e-01 1.31e-04
Cytochrome c-mediated apoptotic response 13 3.33e-02 3.41e-01 6.96e-02
MyD88-independent TLR4 cascade 96 7.99e-09 3.41e-01 1.73e-07
TRIF(TICAM1)-mediated TLR4 signaling 96 7.99e-09 3.41e-01 1.73e-07
Translocation of SLC2A4 (GLUT4) to the plasma membrane 48 4.45e-05 3.41e-01 2.95e-04
Regulation of Apoptosis 52 2.18e-05 3.40e-01 1.60e-04
Negative regulation of FGFR3 signaling 20 8.81e-03 3.38e-01 2.41e-02
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 27 2.38e-03 3.38e-01 8.30e-03
Interleukin-17 signaling 68 1.45e-06 3.38e-01 1.69e-05
Common Pathway of Fibrin Clot Formation 14 2.97e-02 3.36e-01 6.39e-02
Signaling by EGFR 46 8.37e-05 3.35e-01 4.98e-04
Glucagon signaling in metabolic regulation 27 2.63e-03 3.34e-01 9.01e-03
Oncogenic MAPK signaling 73 7.76e-07 3.34e-01 1.03e-05
ER Quality Control Compartment (ERQC) 21 7.99e-03 3.34e-01 2.23e-02
Degradation of GLI2 by the proteasome 57 1.28e-05 3.34e-01 1.00e-04
Cargo recognition for clathrin-mediated endocytosis 90 4.34e-08 3.34e-01 8.11e-07
Diseases of carbohydrate metabolism 29 1.86e-03 3.34e-01 6.80e-03
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 2.62e-05 3.34e-01 1.86e-04
Rev-mediated nuclear export of HIV RNA 35 6.35e-04 -3.34e-01 2.82e-03
SHC1 events in ERBB4 signaling 10 6.80e-02 3.33e-01 1.25e-01
FOXO-mediated transcription of cell death genes 16 2.16e-02 3.32e-01 4.89e-02
Golgi-to-ER retrograde transport 111 1.79e-09 3.30e-01 4.53e-08
GPVI-mediated activation cascade 31 1.48e-03 3.30e-01 5.63e-03
Degradation of GLI1 by the proteasome 58 1.42e-05 3.29e-01 1.08e-04
Regulation of PTEN stability and activity 67 3.28e-06 3.29e-01 3.28e-05
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 51 4.97e-05 3.28e-01 3.22e-04
p53-Independent DNA Damage Response 51 4.97e-05 3.28e-01 3.22e-04
p53-Independent G1/S DNA damage checkpoint 51 4.97e-05 3.28e-01 3.22e-04
Presynaptic phase of homologous DNA pairing and strand exchange 39 4.00e-04 -3.28e-01 1.89e-03
G-protein activation 23 6.68e-03 3.27e-01 1.93e-02
Interactions of Rev with host cellular proteins 37 5.97e-04 -3.26e-01 2.65e-03
VxPx cargo-targeting to cilium 19 1.40e-02 3.25e-01 3.44e-02
Vpu mediated degradation of CD4 51 6.08e-05 3.25e-01 3.81e-04
NIK–>noncanonical NF-kB signaling 58 1.99e-05 3.24e-01 1.47e-04
RAB GEFs exchange GTP for GDP on RABs 88 1.51e-07 3.24e-01 2.49e-06
Synthesis of PC 23 7.24e-03 3.23e-01 2.05e-02
G beta:gamma signalling through BTK 15 3.01e-02 3.23e-01 6.44e-02
E3 ubiquitin ligases ubiquitinate target proteins 52 5.50e-05 3.23e-01 3.50e-04
Activation of Matrix Metalloproteinases 23 7.33e-03 3.23e-01 2.08e-02
Signaling by NOTCH4 79 6.95e-07 3.23e-01 9.58e-06
Presynaptic function of Kainate receptors 18 1.80e-02 3.22e-01 4.22e-02
Nuclear Events (kinase and transcription factor activation) 53 5.25e-05 3.21e-01 3.37e-04
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.67e-03 -3.21e-01 6.23e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 29 2.94e-03 3.19e-01 9.83e-03
GLI3 is processed to GLI3R by the proteasome 58 2.78e-05 3.18e-01 1.96e-04
Protein ubiquitination 72 3.07e-06 3.18e-01 3.15e-05
Dectin-1 mediated noncanonical NF-kB signaling 59 2.42e-05 3.18e-01 1.76e-04
Triglyceride catabolism 16 2.79e-02 3.17e-01 6.07e-02
ERBB2 Regulates Cell Motility 10 8.23e-02 3.17e-01 1.46e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 2.58e-05 3.17e-01 1.85e-04
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 80 9.74e-07 3.17e-01 1.19e-05
Nucleotide salvage 21 1.20e-02 3.17e-01 3.00e-02
TNFR1-induced proapoptotic signaling 12 5.78e-02 -3.16e-01 1.10e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.23e-03 3.16e-01 4.77e-03
Amino acids regulate mTORC1 50 1.16e-04 3.15e-01 6.57e-04
Metabolism of polyamines 58 3.35e-05 3.15e-01 2.28e-04
Ubiquitin-dependent degradation of Cyclin D 51 1.02e-04 3.15e-01 5.88e-04
Apoptotic factor-mediated response 18 2.10e-02 3.14e-01 4.77e-02
Negative regulation of FGFR4 signaling 21 1.27e-02 3.14e-01 3.15e-02
Transport to the Golgi and subsequent modification 155 1.60e-11 3.13e-01 5.89e-10
RORA activates gene expression 18 2.17e-02 3.12e-01 4.91e-02
Metabolism of steroid hormones 21 1.32e-02 3.12e-01 3.27e-02
Metabolism of porphyrins 22 1.15e-02 3.11e-01 2.90e-02
Autophagy 124 2.12e-09 3.11e-01 5.17e-08
Activation of BAD and translocation to mitochondria 15 3.69e-02 3.11e-01 7.53e-02
Signaling by NOTCH 183 3.84e-13 3.11e-01 1.81e-11
Extension of Telomeres 51 1.26e-04 -3.10e-01 7.00e-04
Mitochondrial tRNA aminoacylation 21 1.39e-02 -3.10e-01 3.41e-02
Membrane Trafficking 559 5.33e-36 3.09e-01 1.82e-33
Vpr-mediated nuclear import of PICs 34 1.87e-03 -3.08e-01 6.80e-03
Uptake and actions of bacterial toxins 27 5.68e-03 3.07e-01 1.68e-02
Regulation of RUNX3 expression and activity 55 8.07e-05 3.07e-01 4.84e-04
Effects of PIP2 hydrolysis 24 9.24e-03 -3.07e-01 2.48e-02
ABC transporter disorders 71 7.90e-06 3.07e-01 6.70e-05
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 3.42e-02 3.06e-01 7.11e-02
Diseases of programmed cell death 28 5.10e-03 3.06e-01 1.54e-02
rRNA processing in the nucleus and cytosol 190 3.58e-13 -3.06e-01 1.75e-11
Nuclear import of Rev protein 34 2.04e-03 -3.06e-01 7.26e-03
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 4.78e-02 -3.06e-01 9.42e-02
VEGFA-VEGFR2 Pathway 92 4.27e-07 3.05e-01 6.14e-06
Major pathway of rRNA processing in the nucleolus and cytosol 180 1.68e-12 -3.05e-01 7.18e-11
NS1 Mediated Effects on Host Pathways 40 8.53e-04 -3.05e-01 3.59e-03
Caspase activation via extrinsic apoptotic signalling pathway 25 8.38e-03 3.05e-01 2.31e-02
Polymerase switching on the C-strand of the telomere 26 7.19e-03 -3.05e-01 2.05e-02
Condensation of Prophase Chromosomes 29 4.54e-03 3.04e-01 1.41e-02
L1CAM interactions 85 1.26e-06 3.04e-01 1.49e-05
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 1.37e-02 3.03e-01 3.38e-02
Plasma lipoprotein clearance 29 4.75e-03 3.03e-01 1.47e-02
Acyl chain remodelling of PI 10 9.74e-02 3.03e-01 1.65e-01
Trafficking and processing of endosomal TLR 13 5.88e-02 3.03e-01 1.11e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 4.82e-03 3.02e-01 1.48e-02
Rap1 signalling 13 5.95e-02 3.02e-01 1.12e-01
Glycogen storage diseases 13 6.01e-02 3.01e-01 1.13e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 6.05e-02 3.01e-01 1.13e-01
CLEC7A (Dectin-1) signaling 97 3.16e-07 3.00e-01 4.91e-06
Senescence-Associated Secretory Phenotype (SASP) 66 2.52e-05 3.00e-01 1.81e-04
Activation of G protein gated Potassium channels 20 2.03e-02 3.00e-01 4.63e-02
G protein gated Potassium channels 20 2.03e-02 3.00e-01 4.63e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 2.03e-02 3.00e-01 4.63e-02
Toll Like Receptor 3 (TLR3) Cascade 92 6.70e-07 3.00e-01 9.34e-06
Negative regulation of FGFR1 signaling 24 1.12e-02 2.99e-01 2.83e-02
Autodegradation of the E3 ubiquitin ligase COP1 50 2.53e-04 2.99e-01 1.27e-03
p38MAPK events 13 6.19e-02 2.99e-01 1.15e-01
Selenocysteine synthesis 92 8.72e-07 -2.97e-01 1.07e-05
Signaling by Insulin receptor 59 8.38e-05 2.96e-01 4.98e-04
MET promotes cell motility 26 9.05e-03 2.96e-01 2.44e-02
Chondroitin sulfate biosynthesis 12 7.62e-02 2.96e-01 1.38e-01
CD28 dependent PI3K/Akt signaling 22 1.64e-02 -2.96e-01 3.91e-02
PCP/CE pathway 87 1.87e-06 2.96e-01 2.10e-05
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 3.50e-02 2.95e-01 7.25e-02
Translesion synthesis by REV1 16 4.13e-02 -2.95e-01 8.32e-02
Activation of NF-kappaB in B cells 66 3.57e-05 2.94e-01 2.41e-04
Aquaporin-mediated transport 38 1.72e-03 2.94e-01 6.37e-03
p75NTR signals via NF-kB 15 4.88e-02 2.94e-01 9.57e-02
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.22e-03 2.92e-01 1.07e-02
MASTL Facilitates Mitotic Progression 10 1.10e-01 2.92e-01 1.82e-01
Diseases associated with glycosylation precursor biosynthesis 18 3.27e-02 2.91e-01 6.86e-02
tRNA processing in the nucleus 59 1.15e-04 -2.90e-01 6.52e-04
Prefoldin mediated transfer of substrate to CCT/TriC 26 1.04e-02 2.90e-01 2.71e-02
Receptor Mediated Mitophagy 11 9.58e-02 2.90e-01 1.63e-01
TBC/RABGAPs 45 7.61e-04 2.90e-01 3.26e-03
Formation of tubulin folding intermediates by CCT/TriC 22 1.87e-02 2.90e-01 4.33e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 51 3.51e-04 2.89e-01 1.70e-03
Opioid Signalling 75 1.55e-05 2.89e-01 1.17e-04
Constitutive Signaling by EGFRvIII 14 6.17e-02 2.88e-01 1.15e-01
Signaling by EGFRvIII in Cancer 14 6.17e-02 2.88e-01 1.15e-01
Integration of energy metabolism 86 3.84e-06 2.88e-01 3.65e-05
Misspliced GSK3beta mutants stabilize beta-catenin 15 5.33e-02 2.88e-01 1.03e-01
S33 mutants of beta-catenin aren’t phosphorylated 15 5.33e-02 2.88e-01 1.03e-01
S37 mutants of beta-catenin aren’t phosphorylated 15 5.33e-02 2.88e-01 1.03e-01
S45 mutants of beta-catenin aren’t phosphorylated 15 5.33e-02 2.88e-01 1.03e-01
T41 mutants of beta-catenin aren’t phosphorylated 15 5.33e-02 2.88e-01 1.03e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 5.33e-02 2.88e-01 1.03e-01
G beta:gamma signalling through PI3Kgamma 22 1.93e-02 2.88e-01 4.46e-02
Signaling by PDGFRA extracellular domain mutants 12 8.43e-02 2.88e-01 1.48e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 8.43e-02 2.88e-01 1.48e-01
Signaling by cytosolic FGFR1 fusion mutants 17 4.00e-02 2.88e-01 8.10e-02
Transport of Ribonucleoproteins into the Host Nucleus 32 4.86e-03 -2.88e-01 1.49e-02
Biosynthesis of specialized proresolving mediators (SPMs) 16 4.64e-02 2.88e-01 9.20e-02
Formation of Fibrin Clot (Clotting Cascade) 26 1.12e-02 2.87e-01 2.84e-02
EPHA-mediated growth cone collapse 13 7.31e-02 2.87e-01 1.33e-01
rRNA processing 219 2.40e-13 -2.87e-01 1.49e-11
SCF-beta-TrCP mediated degradation of Emi1 54 2.64e-04 2.87e-01 1.32e-03
Export of Viral Ribonucleoproteins from Nucleus 33 4.60e-03 -2.85e-01 1.43e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 88 3.93e-06 2.85e-01 3.65e-05
Interactions of Vpr with host cellular proteins 37 2.75e-03 -2.84e-01 9.31e-03
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 5.77e-02 2.83e-01 1.10e-01
Signalling to RAS 19 3.27e-02 2.83e-01 6.86e-02
Interferon alpha/beta signaling 57 2.25e-04 -2.82e-01 1.15e-03
Carnitine metabolism 10 1.23e-01 2.82e-01 1.98e-01
Post-chaperonin tubulin folding pathway 19 3.43e-02 2.80e-01 7.12e-02
SHC1 events in ERBB2 signaling 17 4.54e-02 2.80e-01 9.04e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 3.97e-02 2.80e-01 8.05e-02
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 3.97e-02 2.80e-01 8.05e-02
TICAM1,TRAF6-dependent induction of TAK1 complex 11 1.08e-01 2.80e-01 1.79e-01
XBP1(S) activates chaperone genes 47 9.11e-04 2.80e-01 3.76e-03
SIRT1 negatively regulates rRNA expression 24 1.78e-02 2.79e-01 4.19e-02
Peptide chain elongation 88 5.95e-06 -2.79e-01 5.31e-05
Interleukin-4 and Interleukin-13 signaling 92 3.68e-06 2.79e-01 3.59e-05
Beta-oxidation of very long chain fatty acids 10 1.28e-01 2.78e-01 2.04e-01
Signaling by Non-Receptor Tyrosine Kinases 48 8.53e-04 2.78e-01 3.59e-03
Signaling by PTK6 48 8.53e-04 2.78e-01 3.59e-03
Programmed Cell Death 180 1.26e-10 2.78e-01 3.99e-09
Asparagine N-linked glycosylation 269 5.32e-15 2.77e-01 4.03e-13
Interleukin-27 signaling 11 1.12e-01 2.77e-01 1.83e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 1.28e-04 2.77e-01 7.08e-04
G alpha (z) signalling events 36 4.07e-03 2.77e-01 1.29e-02
HDR through Single Strand Annealing (SSA) 37 3.61e-03 -2.76e-01 1.17e-02
Mitotic Telophase/Cytokinesis 13 8.47e-02 2.76e-01 1.49e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 9.79e-02 2.76e-01 1.66e-01
Rab regulation of trafficking 121 1.59e-07 2.76e-01 2.59e-06
Cleavage of the damaged pyrimidine 29 1.04e-02 2.75e-01 2.71e-02
Depyrimidination 29 1.04e-02 2.75e-01 2.71e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 1.04e-02 2.75e-01 2.71e-02
Degradation of AXIN 54 4.87e-04 2.74e-01 2.25e-03
NOTCH1 Intracellular Domain Regulates Transcription 45 1.45e-03 2.74e-01 5.52e-03
Signaling by FGFR3 31 8.41e-03 2.73e-01 2.31e-02
tRNA modification in the nucleus and cytosol 43 1.92e-03 -2.73e-01 6.90e-03
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 7.55e-03 2.73e-01 2.13e-02
Macroautophagy 110 7.88e-07 2.72e-01 1.03e-05
TRAF6 mediated NF-kB activation 23 2.38e-02 2.72e-01 5.32e-02
O-glycosylation of TSR domain-containing proteins 26 1.63e-02 -2.72e-01 3.91e-02
Myogenesis 21 3.11e-02 2.72e-01 6.59e-02
PLC beta mediated events 43 2.09e-03 2.71e-01 7.43e-03
Activation of GABAB receptors 31 8.98e-03 2.71e-01 2.43e-02
GABA B receptor activation 31 8.98e-03 2.71e-01 2.43e-02
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 1.19e-01 -2.71e-01 1.93e-01
TGF-beta receptor signaling activates SMADs 32 7.94e-03 2.71e-01 2.22e-02
PPARA activates gene expression 104 1.84e-06 2.71e-01 2.09e-05
Eukaryotic Translation Elongation 93 6.47e-06 -2.71e-01 5.70e-05
Oxidative Stress Induced Senescence 79 3.24e-05 2.70e-01 2.22e-04
Transport of the SLBP independent Mature mRNA 35 5.65e-03 -2.70e-01 1.67e-02
Interleukin-10 signaling 35 5.66e-03 2.70e-01 1.67e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 8.22e-03 -2.70e-01 2.28e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 8.22e-03 -2.70e-01 2.28e-02
Stabilization of p53 55 5.37e-04 2.70e-01 2.43e-03
Intrinsic Pathway of Fibrin Clot Formation 16 6.18e-02 2.70e-01 1.15e-01
Citric acid cycle (TCA cycle) 22 2.86e-02 2.70e-01 6.19e-02
Signaling by NOTCH1 67 1.37e-04 2.69e-01 7.37e-04
Intra-Golgi and retrograde Golgi-to-ER traffic 179 5.04e-10 2.69e-01 1.39e-08
Signaling by VEGF 100 3.27e-06 2.69e-01 3.28e-05
IRE1alpha activates chaperones 49 1.13e-03 2.69e-01 4.49e-03
Activated NOTCH1 Transmits Signal to the Nucleus 27 1.58e-02 2.68e-01 3.79e-02
Metalloprotease DUBs 21 3.33e-02 2.68e-01 6.96e-02
Vesicle-mediated transport 650 1.64e-31 2.68e-01 4.49e-29
SARS-CoV-2 Infection 63 2.35e-04 2.68e-01 1.20e-03
Apoptosis 168 2.16e-09 2.68e-01 5.17e-08
Signaling by Interleukins 386 1.71e-19 2.68e-01 2.12e-17
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 5.50e-03 2.67e-01 1.64e-02
PKA activation 15 7.31e-02 2.67e-01 1.33e-01
Respiratory electron transport 101 3.58e-06 2.67e-01 3.52e-05
NF-kB is activated and signals survival 12 1.11e-01 2.66e-01 1.82e-01
Signaling by Receptor Tyrosine Kinases 414 1.68e-20 2.66e-01 2.29e-18
Purine ribonucleoside monophosphate biosynthesis 10 1.47e-01 -2.65e-01 2.30e-01
Plasma lipoprotein assembly, remodeling, and clearance 53 8.47e-04 2.65e-01 3.59e-03
MAPK6/MAPK4 signaling 83 3.05e-05 2.65e-01 2.11e-04
Cristae formation 31 1.08e-02 2.65e-01 2.77e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 124 3.67e-07 2.64e-01 5.45e-06
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 2.83e-02 2.64e-01 6.13e-02
Prostacyclin signalling through prostacyclin receptor 16 6.82e-02 2.63e-01 1.25e-01
Eukaryotic Translation Termination 92 1.32e-05 -2.63e-01 1.02e-04
Postmitotic nuclear pore complex (NPC) reformation 27 1.83e-02 -2.62e-01 4.27e-02
Platelet homeostasis 69 1.71e-04 2.62e-01 9.02e-04
Translesion synthesis by POLI 17 6.22e-02 -2.61e-01 1.16e-01
Tie2 Signaling 16 7.05e-02 2.61e-01 1.29e-01
Regulation of signaling by CBL 18 5.52e-02 2.61e-01 1.05e-01
Scavenging by Class A Receptors 12 1.18e-01 2.61e-01 1.92e-01
Viral mRNA Translation 88 2.47e-05 -2.60e-01 1.79e-04
Amine ligand-binding receptors 10 1.55e-01 -2.60e-01 2.40e-01
Caspase activation via Death Receptors in the presence of ligand 16 7.20e-02 2.60e-01 1.32e-01
GABA receptor activation 36 7.11e-03 2.59e-01 2.03e-02
C-type lectin receptors (CLRs) 129 3.78e-07 2.59e-01 5.55e-06
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.78e-02 -2.59e-01 4.19e-02
Signaling by FGFR4 31 1.28e-02 2.58e-01 3.16e-02
APC/C:Cdc20 mediated degradation of Securin 67 2.63e-04 2.58e-01 1.32e-03
AMER1 mutants destabilize the destruction complex 14 9.52e-02 2.58e-01 1.63e-01
APC truncation mutants have impaired AXIN binding 14 9.52e-02 2.58e-01 1.63e-01
AXIN missense mutants destabilize the destruction complex 14 9.52e-02 2.58e-01 1.63e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 9.52e-02 2.58e-01 1.63e-01
Truncations of AMER1 destabilize the destruction complex 14 9.52e-02 2.58e-01 1.63e-01
truncated APC mutants destabilize the destruction complex 14 9.52e-02 2.58e-01 1.63e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 53 1.21e-03 2.57e-01 4.71e-03
Hedgehog ‘on’ state 76 1.08e-04 2.57e-01 6.23e-04
Initiation of Nuclear Envelope (NE) Reformation 19 5.27e-02 2.57e-01 1.03e-01
Defects in vitamin and cofactor metabolism 21 4.23e-02 -2.56e-01 8.50e-02
Regulation of lipid metabolism by PPARalpha 106 5.54e-06 2.55e-01 5.04e-05
IRAK2 mediated activation of TAK1 complex 10 1.62e-01 2.55e-01 2.49e-01
Mitochondrial iron-sulfur cluster biogenesis 13 1.11e-01 2.55e-01 1.83e-01
tRNA processing 136 2.88e-07 -2.55e-01 4.58e-06
Metabolism of non-coding RNA 53 1.35e-03 -2.54e-01 5.18e-03
snRNP Assembly 53 1.35e-03 -2.54e-01 5.18e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 73 1.73e-04 2.54e-01 9.11e-04
Processive synthesis on the C-strand of the telomere 19 5.52e-02 -2.54e-01 1.05e-01
Regulation of insulin secretion 60 6.70e-04 2.54e-01 2.93e-03
Glycosphingolipid metabolism 36 8.40e-03 2.54e-01 2.31e-02
Semaphorin interactions 57 9.23e-04 2.54e-01 3.79e-03
G-protein mediated events 44 3.65e-03 2.53e-01 1.18e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.01e-01 -2.53e-01 1.69e-01
Intraflagellar transport 39 6.22e-03 -2.53e-01 1.82e-02
Base-Excision Repair, AP Site Formation 31 1.50e-02 2.52e-01 3.63e-02
Complex I biogenesis 55 1.21e-03 2.52e-01 4.72e-03
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 36 8.91e-03 2.52e-01 2.42e-02
Degradation of beta-catenin by the destruction complex 84 6.67e-05 2.52e-01 4.12e-04
Transcriptional regulation of white adipocyte differentiation 77 1.36e-04 2.51e-01 7.37e-04
Defective B3GALTL causes Peters-plus syndrome (PpS) 25 3.08e-02 -2.50e-01 6.55e-02
NGF-stimulated transcription 31 1.64e-02 2.49e-01 3.91e-02
PI3K events in ERBB2 signaling 11 1.53e-01 2.49e-01 2.37e-01
p75NTR recruits signalling complexes 12 1.36e-01 2.49e-01 2.15e-01
FGFR1 mutant receptor activation 23 3.91e-02 2.48e-01 7.96e-02
TICAM1, RIP1-mediated IKK complex recruitment 19 6.09e-02 2.48e-01 1.14e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 5.36e-03 -2.48e-01 1.61e-02
Signaling by ERBB4 44 4.37e-03 2.48e-01 1.37e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.59e-02 -2.48e-01 5.70e-02
Nucleobase catabolism 28 2.33e-02 2.48e-01 5.21e-02
Constitutive Signaling by Overexpressed ERBB2 11 1.55e-01 2.48e-01 2.40e-01
Ca-dependent events 29 2.11e-02 2.47e-01 4.79e-02
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 8.67e-02 2.47e-01 1.51e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 1.56e-03 2.47e-01 5.89e-03
Asymmetric localization of PCP proteins 61 8.66e-04 2.47e-01 3.63e-03
CDT1 association with the CDC6:ORC:origin complex 58 1.18e-03 2.46e-01 4.64e-03
SCF(Skp2)-mediated degradation of p27/p21 60 9.73e-04 2.46e-01 3.97e-03
GRB2 events in ERBB2 signaling 11 1.58e-01 2.46e-01 2.43e-01
Signaling by SCF-KIT 40 7.17e-03 2.46e-01 2.05e-02
Transport of the SLBP Dependant Mature mRNA 36 1.08e-02 -2.46e-01 2.76e-02
HDMs demethylate histones 22 4.64e-02 2.45e-01 9.20e-02
Aggrephagy 22 4.66e-02 2.45e-01 9.23e-02
Pyruvate metabolism 28 2.48e-02 2.45e-01 5.49e-02
Hemostasis 549 9.70e-23 2.45e-01 1.89e-20
SARS-CoV-1 Infection 47 3.74e-03 2.44e-01 1.20e-02
RHO GTPase Effectors 250 2.78e-11 2.44e-01 9.74e-10
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 32 1.70e-02 2.44e-01 4.04e-02
Surfactant metabolism 22 4.79e-02 2.44e-01 9.42e-02
Nuclear signaling by ERBB4 24 3.90e-02 2.43e-01 7.94e-02
Listeria monocytogenes entry into host cells 17 8.25e-02 2.43e-01 1.46e-01
Apoptotic execution phase 45 4.77e-03 2.43e-01 1.47e-02
Heme biosynthesis 14 1.15e-01 2.43e-01 1.89e-01
cGMP effects 12 1.45e-01 2.43e-01 2.28e-01
Gluconeogenesis 28 2.62e-02 2.43e-01 5.75e-02
ESR-mediated signaling 161 1.07e-07 2.43e-01 1.83e-06
Laminin interactions 21 5.43e-02 2.43e-01 1.04e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 4.84e-05 -2.42e-01 3.18e-04
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 3.26e-02 -2.42e-01 6.85e-02
tRNA Aminoacylation 42 6.78e-03 -2.41e-01 1.95e-02
Mismatch Repair 15 1.06e-01 -2.41e-01 1.77e-01
Translesion synthesis by POLK 17 8.56e-02 -2.41e-01 1.50e-01
Regulation of RAS by GAPs 67 6.68e-04 2.40e-01 2.93e-03
The citric acid (TCA) cycle and respiratory electron transport 172 5.61e-08 2.40e-01 9.82e-07
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 8.86e-03 2.39e-01 2.41e-02
Interleukin-15 signaling 14 1.22e-01 2.38e-01 1.97e-01
Sphingolipid metabolism 78 2.72e-04 2.38e-01 1.35e-03
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 54 2.55e-03 2.37e-01 8.78e-03
Constitutive Signaling by NOTCH1 PEST Domain Mutants 54 2.55e-03 2.37e-01 8.78e-03
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 54 2.55e-03 2.37e-01 8.78e-03
Signaling by NOTCH1 PEST Domain Mutants in Cancer 54 2.55e-03 2.37e-01 8.78e-03
Signaling by NOTCH1 in Cancer 54 2.55e-03 2.37e-01 8.78e-03
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 8.14e-02 2.37e-01 1.45e-01
Signaling by Hippo 18 8.17e-02 2.37e-01 1.45e-01
Activation of gene expression by SREBF (SREBP) 42 7.92e-03 2.37e-01 2.22e-02
Plasma lipoprotein assembly 10 1.97e-01 2.36e-01 2.96e-01
Extra-nuclear estrogen signaling 66 9.28e-04 2.36e-01 3.79e-03
Glycerophospholipid biosynthesis 106 2.89e-05 2.35e-01 2.02e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 72 5.71e-04 2.35e-01 2.57e-03
CDK-mediated phosphorylation and removal of Cdc6 72 5.83e-04 2.34e-01 2.60e-03
Acyl chain remodelling of PC 19 7.71e-02 2.34e-01 1.38e-01
Downstream signaling events of B Cell Receptor (BCR) 80 2.96e-04 2.34e-01 1.46e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 73 5.49e-04 2.34e-01 2.48e-03
Keratinization 33 2.01e-02 2.34e-01 4.62e-02
Depolymerisation of the Nuclear Lamina 15 1.19e-01 2.32e-01 1.93e-01
mRNA decay by 3’ to 5’ exoribonuclease 16 1.07e-01 -2.32e-01 1.79e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 76 4.70e-04 2.32e-01 2.18e-03
RIPK1-mediated regulated necrosis 29 3.09e-02 2.32e-01 6.55e-02
Regulated Necrosis 29 3.09e-02 2.32e-01 6.55e-02
Regulation of necroptotic cell death 29 3.09e-02 2.32e-01 6.55e-02
HDR through Homologous Recombination (HRR) 66 1.15e-03 -2.31e-01 4.56e-03
COPI-dependent Golgi-to-ER retrograde traffic 78 4.28e-04 2.31e-01 2.01e-03
RA biosynthesis pathway 13 1.50e-01 -2.30e-01 2.33e-01
Chaperonin-mediated protein folding 84 2.68e-04 2.30e-01 1.34e-03
APC/C:Cdc20 mediated degradation of mitotic proteins 75 5.83e-04 2.30e-01 2.60e-03
The role of Nef in HIV-1 replication and disease pathogenesis 28 3.58e-02 2.29e-01 7.37e-02
Intra-Golgi traffic 43 9.48e-03 2.29e-01 2.52e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 43 9.62e-03 -2.28e-01 2.55e-02
Phase 0 - rapid depolarisation 22 6.53e-02 -2.27e-01 1.21e-01
Oncogene Induced Senescence 33 2.40e-02 2.27e-01 5.35e-02
Beta-catenin independent WNT signaling 137 4.52e-06 2.27e-01 4.17e-05
Diseases of signal transduction by growth factor receptors and second messengers 342 6.05e-13 2.26e-01 2.67e-11
Selenoamino acid metabolism 114 2.96e-05 -2.26e-01 2.06e-04
NOD1/2 Signaling Pathway 32 2.68e-02 2.26e-01 5.86e-02
Tryptophan catabolism 12 1.75e-01 2.26e-01 2.66e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 1.44e-01 2.26e-01 2.26e-01
UCH proteinases 87 2.83e-04 2.25e-01 1.40e-03
ABC-family proteins mediated transport 94 1.66e-04 2.25e-01 8.84e-04
p53-Dependent G1 DNA Damage Response 64 1.89e-03 2.25e-01 6.83e-03
p53-Dependent G1/S DNA damage checkpoint 64 1.89e-03 2.25e-01 6.83e-03
Sphingolipid de novo biosynthesis 42 1.19e-02 2.24e-01 2.97e-02
Plasma lipoprotein remodeling 18 9.94e-02 2.24e-01 1.68e-01
Signaling by NOTCH3 43 1.11e-02 2.24e-01 2.83e-02
Costimulation by the CD28 family 74 8.86e-04 -2.23e-01 3.70e-03
Degradation of the extracellular matrix 78 6.48e-04 2.23e-01 2.86e-03
Influenza Viral RNA Transcription and Replication 135 7.53e-06 -2.23e-01 6.43e-05
TP53 Regulates Metabolic Genes 85 3.76e-04 2.23e-01 1.80e-03
Gap-filling DNA repair synthesis and ligation in GG-NER 25 5.39e-02 -2.23e-01 1.04e-01
G1/S DNA Damage Checkpoints 66 1.79e-03 2.22e-01 6.56e-03
Estrogen-dependent gene expression 99 1.33e-04 2.22e-01 7.22e-04
EPH-ephrin mediated repulsion of cells 40 1.52e-02 2.22e-01 3.67e-02
Regulation of RUNX2 expression and activity 67 1.71e-03 2.22e-01 6.33e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 1.46e-04 -2.20e-01 7.84e-04
Selective autophagy 58 3.80e-03 2.20e-01 1.22e-02
Signaling by ERBB2 in Cancer 21 8.27e-02 2.19e-01 1.46e-01
Adenylate cyclase inhibitory pathway 11 2.10e-01 2.19e-01 3.11e-01
Downregulation of ERBB2 signaling 24 6.39e-02 2.18e-01 1.18e-01
NRIF signals cell death from the nucleus 15 1.45e-01 2.18e-01 2.27e-01
Chaperone Mediated Autophagy 20 9.61e-02 2.15e-01 1.64e-01
Removal of the Flap Intermediate from the C-strand 17 1.25e-01 -2.15e-01 2.01e-01
Signaling by Nuclear Receptors 217 5.11e-08 2.15e-01 9.42e-07
Signaling by WNT 254 4.05e-09 2.14e-01 9.22e-08
PTEN Regulation 139 1.30e-05 2.14e-01 1.01e-04
Negative regulation of FGFR2 signaling 23 7.66e-02 2.13e-01 1.38e-01
Formation of the beta-catenin:TCF transactivating complex 46 1.26e-02 2.13e-01 3.13e-02
Transport of bile salts and organic acids, metal ions and amine compounds 55 6.53e-03 2.12e-01 1.89e-02
Interleukin-12 family signaling 53 7.67e-03 2.12e-01 2.16e-02
SUMOylation of SUMOylation proteins 35 3.02e-02 -2.12e-01 6.46e-02
Interleukin-12 signaling 44 1.54e-02 2.11e-01 3.72e-02
Sialic acid metabolism 28 5.34e-02 2.11e-01 1.03e-01
Purine salvage 12 2.06e-01 2.11e-01 3.08e-01
Retinoid metabolism and transport 24 7.37e-02 2.11e-01 1.34e-01
Signaling by Rho GTPases 367 4.57e-12 2.10e-01 1.84e-10
TCF dependent signaling in response to WNT 166 3.21e-06 2.09e-01 3.27e-05
NOTCH3 Intracellular Domain Regulates Transcription 21 9.74e-02 2.09e-01 1.65e-01
Attenuation phase 23 8.28e-02 2.09e-01 1.46e-01
Integrin cell surface interactions 52 9.18e-03 2.09e-01 2.47e-02
Transcriptional Regulation by E2F6 34 3.52e-02 -2.09e-01 7.27e-02
Striated Muscle Contraction 24 7.76e-02 2.08e-01 1.39e-01
Metabolism of fat-soluble vitamins 28 5.67e-02 2.08e-01 1.08e-01
Synthesis of PIPs at the late endosome membrane 11 2.32e-01 2.08e-01 3.37e-01
Inwardly rectifying K+ channels 24 7.79e-02 2.08e-01 1.40e-01
Protein folding 90 6.57e-04 2.08e-01 2.90e-03
MHC class II antigen presentation 101 3.09e-04 2.08e-01 1.51e-03
Interleukin-6 family signaling 18 1.30e-01 2.06e-01 2.08e-01
Termination of translesion DNA synthesis 32 4.40e-02 -2.06e-01 8.81e-02
Formation of a pool of free 40S subunits 100 3.77e-04 -2.06e-01 1.80e-03
Assembly of active LPL and LIPC lipase complexes 10 2.60e-01 2.06e-01 3.68e-01
RUNX3 regulates NOTCH signaling 14 1.85e-01 2.05e-01 2.81e-01
ABC transporters in lipid homeostasis 14 1.86e-01 -2.04e-01 2.81e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 7.71e-02 2.04e-01 1.38e-01
p75 NTR receptor-mediated signalling 89 9.07e-04 2.03e-01 3.76e-03
Insulin processing 21 1.09e-01 2.02e-01 1.81e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 1.19e-02 2.02e-01 2.97e-02
Elastic fibre formation 32 4.85e-02 2.01e-01 9.53e-02
Transcriptional regulation by RUNX3 90 1.01e-03 2.01e-01 4.08e-03
SUMOylation of intracellular receptors 26 7.68e-02 2.00e-01 1.38e-01
SARS-CoV Infections 140 4.53e-05 2.00e-01 2.99e-04
CaM pathway 27 7.26e-02 2.00e-01 1.32e-01
Calmodulin induced events 27 7.26e-02 2.00e-01 1.32e-01
Biosynthesis of DHA-derived SPMs 14 1.97e-01 1.99e-01 2.97e-01
Signaling by FGFR1 38 3.40e-02 1.99e-01 7.08e-02
RNA Polymerase I Transcription Initiation 44 2.27e-02 -1.98e-01 5.12e-02
RET signaling 32 5.21e-02 1.98e-01 1.02e-01
Immune System 1893 3.24e-46 1.98e-01 1.48e-43
RIP-mediated NFkB activation via ZBP1 17 1.60e-01 1.97e-01 2.46e-01
Regulation of TP53 Activity through Acetylation 29 6.76e-02 -1.96e-01 1.24e-01
Cohesin Loading onto Chromatin 10 2.84e-01 1.96e-01 3.93e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 2.42e-01 -1.95e-01 3.47e-01
Signaling by TGF-beta Receptor Complex 72 4.29e-03 1.95e-01 1.35e-02
BBSome-mediated cargo-targeting to cilium 22 1.14e-01 -1.94e-01 1.87e-01
DAP12 interactions 39 3.59e-02 1.94e-01 7.38e-02
Signaling by FGFR1 in disease 30 6.60e-02 1.94e-01 1.22e-01
NR1H2 and NR1H3-mediated signaling 39 3.61e-02 1.94e-01 7.41e-02
Downregulation of TGF-beta receptor signaling 26 8.73e-02 1.94e-01 1.52e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 3.56e-04 -1.94e-01 1.71e-03
Nonsense-Mediated Decay (NMD) 114 3.56e-04 -1.94e-01 1.71e-03
Diseases associated with O-glycosylation of proteins 48 2.04e-02 -1.93e-01 4.66e-02
Negative regulation of MAPK pathway 42 3.02e-02 1.93e-01 6.46e-02
Regulation of APC/C activators between G1/S and early anaphase 80 2.83e-03 1.93e-01 9.54e-03
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 1.26e-01 1.93e-01 2.02e-01
Cellular Senescence 144 6.80e-05 1.92e-01 4.19e-04
Arachidonic acid metabolism 43 2.93e-02 1.92e-01 6.31e-02
PRC2 methylates histones and DNA 29 7.36e-02 1.92e-01 1.33e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 2.14e-01 -1.92e-01 3.17e-01
Ion channel transport 135 1.22e-04 1.92e-01 6.84e-04
Metabolism of cofactors 19 1.49e-01 1.91e-01 2.32e-01
Signaling by ERBB2 TMD/JMD mutants 17 1.72e-01 1.91e-01 2.62e-01
ZBP1(DAI) mediated induction of type I IFNs 20 1.39e-01 1.91e-01 2.20e-01
DNA Damage/Telomere Stress Induced Senescence 44 2.85e-02 1.91e-01 6.17e-02
Metabolism of amine-derived hormones 10 2.99e-01 -1.90e-01 4.09e-01
Transport of small molecules 561 1.57e-14 1.90e-01 1.07e-12
Activation of HOX genes during differentiation 69 6.52e-03 1.89e-01 1.89e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 69 6.52e-03 1.89e-01 1.89e-02
Metabolism of steroids 120 3.42e-04 1.89e-01 1.66e-03
FRS-mediated FGFR3 signaling 11 2.78e-01 1.89e-01 3.88e-01
RNA Polymerase III Chain Elongation 18 1.66e-01 -1.89e-01 2.53e-01
PINK1-PRKN Mediated Mitophagy 21 1.35e-01 1.88e-01 2.15e-01
Acyl chain remodelling of PE 20 1.45e-01 1.88e-01 2.28e-01
PKA-mediated phosphorylation of CREB 17 1.80e-01 1.88e-01 2.74e-01
Triglyceride metabolism 25 1.05e-01 1.87e-01 1.75e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 6.33e-02 1.87e-01 1.18e-01
PIP3 activates AKT signaling 241 6.02e-07 1.87e-01 8.47e-06
Phospholipid metabolism 185 1.23e-05 1.86e-01 9.85e-05
CD209 (DC-SIGN) signaling 20 1.50e-01 1.86e-01 2.33e-01
Nuclear Pore Complex (NPC) Disassembly 36 5.36e-02 -1.86e-01 1.03e-01
Signaling by ERBB2 KD Mutants 20 1.50e-01 1.86e-01 2.33e-01
Phase 2 - plateau phase 11 2.86e-01 -1.86e-01 3.95e-01
Cytosolic iron-sulfur cluster assembly 13 2.46e-01 -1.86e-01 3.53e-01
Transcriptional regulation by RUNX2 103 1.14e-03 1.86e-01 4.52e-03
Extracellular matrix organization 219 2.25e-06 1.85e-01 2.48e-05
Nitric oxide stimulates guanylate cyclase 15 2.14e-01 1.85e-01 3.17e-01
Mitophagy 28 8.99e-02 1.85e-01 1.56e-01
Regulation of IFNA signaling 12 2.67e-01 1.85e-01 3.76e-01
Antiviral mechanism by IFN-stimulated genes 80 4.28e-03 -1.85e-01 1.35e-02
Collagen formation 66 9.52e-03 1.85e-01 2.53e-02
Regulation of localization of FOXO transcription factors 12 2.71e-01 1.84e-01 3.80e-01
Peroxisomal protein import 57 1.71e-02 1.83e-01 4.04e-02
Metabolism of lipids 626 6.70e-15 1.82e-01 4.81e-13
Activation of kainate receptors upon glutamate binding 26 1.08e-01 1.82e-01 1.79e-01
Assembly of the pre-replicative complex 67 9.99e-03 1.82e-01 2.63e-02
Stimuli-sensing channels 74 6.87e-03 1.82e-01 1.97e-02
Disorders of Developmental Biology 12 2.76e-01 1.82e-01 3.86e-01
Disorders of Nervous System Development 12 2.76e-01 1.82e-01 3.86e-01
Loss of function of MECP2 in Rett syndrome 12 2.76e-01 1.82e-01 3.86e-01
Pervasive developmental disorders 12 2.76e-01 1.82e-01 3.86e-01
Signaling by TGFB family members 91 2.84e-03 1.81e-01 9.57e-03
APC/C-mediated degradation of cell cycle proteins 87 3.52e-03 1.81e-01 1.15e-02
Regulation of mitotic cell cycle 87 3.52e-03 1.81e-01 1.15e-02
SUMOylation of RNA binding proteins 47 3.20e-02 -1.81e-01 6.74e-02
Synthesis of PE 12 2.79e-01 -1.81e-01 3.88e-01
Intracellular signaling by second messengers 273 3.32e-07 1.79e-01 4.99e-06
Influenza Infection 154 1.22e-04 -1.79e-01 6.84e-04
Ub-specific processing proteases 171 5.65e-05 1.78e-01 3.57e-04
NCAM1 interactions 23 1.39e-01 -1.78e-01 2.19e-01
Factors involved in megakaryocyte development and platelet production 117 8.93e-04 1.78e-01 3.71e-03
SUMOylation of ubiquitinylation proteins 39 5.48e-02 -1.78e-01 1.05e-01
Retrograde transport at the Trans-Golgi-Network 49 3.17e-02 1.77e-01 6.69e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 2.87e-01 1.77e-01 3.97e-01
Glutathione conjugation 26 1.18e-01 1.77e-01 1.92e-01
Resolution of D-Loop Structures 33 7.85e-02 -1.77e-01 1.40e-01
Acyl chain remodelling of PG 11 3.12e-01 1.76e-01 4.23e-01
Cyclin E associated events during G1/S transition 83 5.53e-03 1.76e-01 1.65e-02
Peptide hormone metabolism 50 3.13e-02 1.76e-01 6.61e-02
Cell junction organization 60 1.85e-02 1.76e-01 4.28e-02
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 2.11e-01 -1.75e-01 3.13e-01
Synthesis of very long-chain fatty acyl-CoAs 22 1.56e-01 1.75e-01 2.41e-01
Apoptotic cleavage of cellular proteins 34 7.85e-02 1.74e-01 1.40e-01
B-WICH complex positively regulates rRNA expression 44 4.55e-02 1.74e-01 9.04e-02
Circadian Clock 67 1.37e-02 1.74e-01 3.37e-02
Nef mediated downregulation of MHC class I complex cell surface expression 10 3.41e-01 1.74e-01 4.51e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 8.89e-02 -1.74e-01 1.54e-01
Peroxisomal lipid metabolism 27 1.19e-01 1.74e-01 1.92e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 80 7.44e-03 1.73e-01 2.10e-02
Meiotic synapsis 45 4.48e-02 1.73e-01 8.95e-02
Deubiquitination 242 3.70e-06 1.73e-01 3.59e-05
Class I MHC mediated antigen processing & presentation 350 2.99e-08 1.72e-01 5.84e-07
Regulation of PTEN gene transcription 59 2.23e-02 1.72e-01 5.03e-02
Signaling by Hedgehog 121 1.10e-03 1.72e-01 4.41e-03
Unfolded Protein Response (UPR) 87 5.84e-03 1.71e-01 1.72e-02
RNA Polymerase III Transcription Initiation 36 7.66e-02 -1.71e-01 1.38e-01
Neurotransmitter receptors and postsynaptic signal transmission 124 1.06e-03 1.70e-01 4.26e-03
HS-GAG biosynthesis 20 1.88e-01 1.70e-01 2.85e-01
CD28 dependent Vav1 pathway 12 3.08e-01 1.70e-01 4.19e-01
Signaling by PDGFR in disease 19 2.02e-01 1.69e-01 3.03e-01
Pausing and recovery of Tat-mediated HIV elongation 30 1.10e-01 1.69e-01 1.81e-01
Tat-mediated HIV elongation arrest and recovery 30 1.10e-01 1.69e-01 1.81e-01
HCMV Late Events 69 1.53e-02 1.69e-01 3.70e-02
Maturation of nucleoprotein 10 3.55e-01 -1.69e-01 4.64e-01
MAPK1/MAPK3 signaling 236 8.18e-06 1.69e-01 6.90e-05
Signaling by ERBB2 44 5.38e-02 1.68e-01 1.04e-01
G alpha (12/13) signalling events 69 1.67e-02 1.67e-01 3.98e-02
Mitochondrial biogenesis 88 7.05e-03 1.66e-01 2.02e-02
MAPK family signaling cascades 270 2.63e-06 1.66e-01 2.72e-05
VEGFR2 mediated cell proliferation 18 2.23e-01 1.66e-01 3.26e-01
Other semaphorin interactions 16 2.52e-01 1.65e-01 3.59e-01
Carboxyterminal post-translational modifications of tubulin 27 1.37e-01 1.65e-01 2.18e-01
Defects in cobalamin (B12) metabolism 13 3.03e-01 -1.65e-01 4.14e-01
Recognition of DNA damage by PCNA-containing replication complex 30 1.19e-01 -1.65e-01 1.92e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 2.27e-01 1.64e-01 3.32e-01
Dual Incision in GG-NER 41 6.86e-02 -1.64e-01 1.26e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 3.45e-01 1.64e-01 4.55e-01
Glycosaminoglycan metabolism 94 5.91e-03 1.64e-01 1.74e-02
NoRC negatively regulates rRNA expression 59 2.92e-02 1.64e-01 6.31e-02
RNA Polymerase I Promoter Escape 44 6.00e-02 1.64e-01 1.13e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 2.05e-01 1.64e-01 3.07e-01
Trafficking of AMPA receptors 20 2.05e-01 1.64e-01 3.07e-01
Insulin receptor signalling cascade 39 7.68e-02 1.64e-01 1.38e-01
Incretin synthesis, secretion, and inactivation 10 3.71e-01 1.63e-01 4.78e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 10 3.71e-01 1.63e-01 4.78e-01
Metabolism of carbohydrates 244 1.10e-05 1.63e-01 8.84e-05
Rho GTPase cycle 126 1.57e-03 1.63e-01 5.91e-03
Downstream signal transduction 27 1.42e-01 1.63e-01 2.24e-01
Activation of RAC1 11 3.49e-01 1.63e-01 4.59e-01
Intrinsic Pathway for Apoptosis 53 4.03e-02 1.63e-01 8.14e-02
Regulation of actin dynamics for phagocytic cup formation 123 1.85e-03 1.62e-01 6.78e-03
Dectin-2 family 19 2.22e-01 1.62e-01 3.26e-01
FLT3 Signaling 245 1.28e-05 1.62e-01 1.00e-04
Constitutive Signaling by AKT1 E17K in Cancer 26 1.55e-01 1.61e-01 2.40e-01
rRNA processing in the mitochondrion 29 1.34e-01 -1.61e-01 2.14e-01
SUMOylation of DNA damage response and repair proteins 77 1.48e-02 -1.61e-01 3.62e-02
Aflatoxin activation and detoxification 14 2.99e-01 1.60e-01 4.09e-01
Neddylation 219 4.38e-05 1.60e-01 2.92e-04
HIV elongation arrest and recovery 32 1.18e-01 1.60e-01 1.92e-01
Pausing and recovery of HIV elongation 32 1.18e-01 1.60e-01 1.92e-01
Cyclin A:Cdk2-associated events at S phase entry 85 1.09e-02 1.60e-01 2.79e-02
FRS-mediated FGFR4 signaling 12 3.40e-01 1.59e-01 4.51e-01
RAF/MAP kinase cascade 231 3.18e-05 1.59e-01 2.20e-04
Bile acid and bile salt metabolism 28 1.49e-01 1.58e-01 2.32e-01
Hedgehog ‘off’ state 93 8.83e-03 1.57e-01 2.41e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 23 1.92e-01 1.57e-01 2.90e-01
A tetrasaccharide linker sequence is required for GAG synthesis 17 2.65e-01 -1.56e-01 3.75e-01
Metabolic disorders of biological oxidation enzymes 26 1.68e-01 1.56e-01 2.57e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 2.30e-02 -1.55e-01 5.17e-02
Downregulation of ERBB2:ERBB3 signaling 12 3.53e-01 1.55e-01 4.62e-01
Deadenylation of mRNA 22 2.09e-01 1.55e-01 3.11e-01
Interferon Signaling 177 3.85e-04 -1.55e-01 1.82e-03
Signaling by ERBB2 ECD mutants 15 3.03e-01 1.54e-01 4.13e-01
Degradation of cysteine and homocysteine 12 3.57e-01 1.54e-01 4.65e-01
Potential therapeutics for SARS 78 1.94e-02 1.53e-01 4.47e-02
Post-translational protein modification 1193 6.81e-19 1.52e-01 7.16e-17
Fatty acid metabolism 153 1.16e-03 1.52e-01 4.58e-03
Signal Transduction 1894 7.04e-28 1.52e-01 1.60e-25
ISG15 antiviral mechanism 72 2.60e-02 -1.52e-01 5.73e-02
Formation of RNA Pol II elongation complex 57 4.80e-02 1.51e-01 9.42e-02
RNA Polymerase II Transcription Elongation 57 4.80e-02 1.51e-01 9.42e-02
Fatty acyl-CoA biosynthesis 35 1.21e-01 1.51e-01 1.95e-01
Blood group systems biosynthesis 17 2.81e-01 1.51e-01 3.90e-01
TNFR2 non-canonical NF-kB pathway 96 1.06e-02 1.51e-01 2.74e-02
HCMV Infection 96 1.07e-02 1.51e-01 2.75e-02
Chemokine receptors bind chemokines 39 1.03e-01 -1.51e-01 1.73e-01
SLBP independent Processing of Histone Pre-mRNAs 10 4.10e-01 -1.51e-01 5.20e-01
Leishmania infection 245 5.06e-05 1.50e-01 3.26e-04
Disorders of transmembrane transporters 148 1.67e-03 1.50e-01 6.23e-03
Signaling by NTRK2 (TRKB) 20 2.47e-01 1.50e-01 3.53e-01
Transcriptional regulation by RUNX1 185 4.54e-04 1.49e-01 2.12e-03
Early Phase of HIV Life Cycle 14 3.34e-01 -1.49e-01 4.46e-01
Transmission across Chemical Synapses 172 7.60e-04 1.49e-01 3.26e-03
Repression of WNT target genes 14 3.36e-01 -1.48e-01 4.47e-01
Transport of vitamins, nucleosides, and related molecules 33 1.41e-01 1.48e-01 2.22e-01
NOTCH2 intracellular domain regulates transcription 11 3.95e-01 1.48e-01 5.07e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 2.93e-01 -1.47e-01 4.03e-01
Miscellaneous transport and binding events 20 2.54e-01 1.47e-01 3.61e-01
Death Receptor Signalling 132 3.50e-03 1.47e-01 1.15e-02
Cell death signalling via NRAGE, NRIF and NADE 70 3.34e-02 1.47e-01 6.97e-02
Transcriptional Regulation by MECP2 47 8.13e-02 1.47e-01 1.45e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 2.11e-03 1.47e-01 7.48e-03
MET activates PTK2 signaling 15 3.25e-01 1.47e-01 4.38e-01
Cell-Cell communication 89 1.71e-02 1.46e-01 4.04e-02
RAF-independent MAPK1/3 activation 21 2.47e-01 1.46e-01 3.53e-01
Cellular responses to external stimuli 506 1.91e-08 1.46e-01 3.89e-07
GTP hydrolysis and joining of the 60S ribosomal subunit 111 8.23e-03 -1.45e-01 2.28e-02
tRNA processing in the mitochondrion 32 1.55e-01 -1.45e-01 2.40e-01
Synthesis of bile acids and bile salts 24 2.21e-01 1.44e-01 3.24e-01
Interferon gamma signaling 83 2.32e-02 -1.44e-01 5.21e-02
Adrenaline,noradrenaline inhibits insulin secretion 24 2.22e-01 1.44e-01 3.26e-01
SUMOylation of DNA replication proteins 46 9.14e-02 -1.44e-01 1.58e-01
FRS-mediated FGFR1 signaling 14 3.52e-01 1.44e-01 4.61e-01
Vitamin B5 (pantothenate) metabolism 17 3.05e-01 1.44e-01 4.15e-01
Signaling by FGFR2 IIIa TM 18 2.95e-01 1.43e-01 4.05e-01
HS-GAG degradation 16 3.25e-01 1.42e-01 4.38e-01
Cellular responses to stress 500 5.60e-08 1.42e-01 9.82e-07
HIV Transcription Initiation 45 9.99e-02 1.42e-01 1.68e-01
RNA Polymerase II HIV Promoter Escape 45 9.99e-02 1.42e-01 1.68e-01
RNA Polymerase II Promoter Escape 45 9.99e-02 1.42e-01 1.68e-01
RNA Polymerase II Transcription Initiation 45 9.99e-02 1.42e-01 1.68e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 9.99e-02 1.42e-01 1.68e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 9.99e-02 1.42e-01 1.68e-01
Metabolism of folate and pterines 16 3.26e-01 1.42e-01 4.39e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 1.05e-02 -1.41e-01 2.73e-02
Signaling by Activin 10 4.40e-01 -1.41e-01 5.49e-01
SUMOylation of chromatin organization proteins 57 6.56e-02 -1.41e-01 1.21e-01
Collagen biosynthesis and modifying enzymes 48 9.20e-02 1.41e-01 1.59e-01
FCGR activation 76 3.45e-02 -1.40e-01 7.14e-02
Negative regulation of the PI3K/AKT network 87 2.39e-02 1.40e-01 5.34e-02
RNA Pol II CTD phosphorylation and interaction with CE 27 2.08e-01 1.40e-01 3.10e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 2.08e-01 1.40e-01 3.10e-01
Polo-like kinase mediated events 16 3.33e-01 1.40e-01 4.45e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 2.27e-01 1.40e-01 3.31e-01
Muscle contraction 136 4.93e-03 1.40e-01 1.50e-02
Metabolism 1772 1.65e-22 1.40e-01 2.81e-20
Translation of structural proteins 28 2.02e-01 1.39e-01 3.03e-01
Assembly of collagen fibrils and other multimeric structures 42 1.20e-01 1.39e-01 1.93e-01
Signaling by PDGF 44 1.12e-01 1.39e-01 1.83e-01
FOXO-mediated transcription 59 6.72e-02 1.38e-01 1.24e-01
Regulation of TP53 Activity through Association with Co-factors 12 4.09e-01 -1.38e-01 5.20e-01
TP53 Regulates Transcription of Cell Death Genes 43 1.20e-01 1.37e-01 1.94e-01
Folding of actin by CCT/TriC 10 4.53e-01 1.37e-01 5.63e-01
FCGR3A-mediated phagocytosis 121 9.35e-03 1.37e-01 2.50e-02
Leishmania phagocytosis 121 9.35e-03 1.37e-01 2.50e-02
Parasite infection 121 9.35e-03 1.37e-01 2.50e-02
Regulation of MECP2 expression and activity 28 2.10e-01 1.37e-01 3.12e-01
Signaling by FGFR in disease 50 9.53e-02 1.36e-01 1.63e-01
Synthesis of PIPs at the plasma membrane 52 8.98e-02 1.36e-01 1.56e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 4.57e-01 1.36e-01 5.66e-01
Downstream signaling of activated FGFR3 16 3.48e-01 1.35e-01 4.59e-01
Transport of Mature Transcript to Cytoplasm 81 3.56e-02 -1.35e-01 7.34e-02
Phase 4 - resting membrane potential 10 4.63e-01 1.34e-01 5.72e-01
Metal ion SLC transporters 21 2.88e-01 1.34e-01 3.98e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 182 1.89e-03 -1.34e-01 6.83e-03
SUMOylation of transcription factors 16 3.57e-01 1.33e-01 4.65e-01
Developmental Biology 732 1.07e-09 1.32e-01 2.75e-08
SRP-dependent cotranslational protein targeting to membrane 111 1.62e-02 -1.32e-01 3.89e-02
RNA Polymerase II Pre-transcription Events 78 4.41e-02 1.32e-01 8.81e-02
Zinc transporters 14 3.93e-01 1.32e-01 5.05e-01
Orc1 removal from chromatin 70 5.76e-02 1.31e-01 1.10e-01
Fc epsilon receptor (FCERI) signaling 191 1.77e-03 1.31e-01 6.51e-03
Classical antibody-mediated complement activation 69 5.97e-02 -1.31e-01 1.13e-01
O-linked glycosylation of mucins 47 1.21e-01 1.31e-01 1.95e-01
CD22 mediated BCR regulation 59 8.26e-02 -1.31e-01 1.46e-01
Metabolism of proteins 1718 2.21e-19 1.31e-01 2.52e-17
Protein methylation 15 3.83e-01 1.30e-01 4.93e-01
The canonical retinoid cycle in rods (twilight vision) 10 4.76e-01 1.30e-01 5.85e-01
Cap-dependent Translation Initiation 118 1.50e-02 -1.30e-01 3.63e-02
Eukaryotic Translation Initiation 118 1.50e-02 -1.30e-01 3.63e-02
Synthesis of substrates in N-glycan biosythesis 58 8.82e-02 1.29e-01 1.53e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 4.21e-01 1.29e-01 5.34e-01
Long-term potentiation 14 4.04e-01 -1.29e-01 5.16e-01
RAS processing 19 3.32e-01 1.28e-01 4.45e-01
HIV Infection 225 9.21e-04 1.28e-01 3.79e-03
Viral Messenger RNA Synthesis 44 1.42e-01 -1.28e-01 2.24e-01
Cytosolic tRNA aminoacylation 24 2.78e-01 -1.28e-01 3.88e-01
Disease 1355 2.72e-15 1.28e-01 2.18e-13
Amino acid transport across the plasma membrane 24 2.81e-01 1.27e-01 3.90e-01
Transcriptional regulation of pluripotent stem cells 20 3.26e-01 1.27e-01 4.39e-01
Formation of the Early Elongation Complex 33 2.09e-01 1.26e-01 3.11e-01
Formation of the HIV-1 Early Elongation Complex 33 2.09e-01 1.26e-01 3.11e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 2.48e-01 -1.26e-01 3.54e-01
Translesion Synthesis by POLH 18 3.56e-01 -1.26e-01 4.64e-01
Cytosolic sulfonation of small molecules 18 3.58e-01 1.25e-01 4.65e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 2.80e-01 1.25e-01 3.89e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 3.35e-01 1.25e-01 4.47e-01
Telomere Extension By Telomerase 23 3.01e-01 -1.24e-01 4.12e-01
Negative epigenetic regulation of rRNA expression 62 9.09e-02 1.24e-01 1.57e-01
Ephrin signaling 18 3.62e-01 1.24e-01 4.70e-01
RUNX3 regulates p14-ARF 10 4.97e-01 1.24e-01 6.04e-01
HSF1-dependent transactivation 29 2.49e-01 1.24e-01 3.54e-01
Regulation of beta-cell development 19 3.52e-01 1.23e-01 4.61e-01
Cell surface interactions at the vascular wall 174 5.36e-03 1.22e-01 1.61e-02
Meiotic recombination 38 1.94e-01 1.22e-01 2.92e-01
Class I peroxisomal membrane protein import 20 3.49e-01 -1.21e-01 4.59e-01
Infectious disease 777 1.03e-08 1.21e-01 2.18e-07
E2F mediated regulation of DNA replication 22 3.32e-01 -1.20e-01 4.45e-01
Potassium Channels 64 9.86e-02 1.19e-01 1.67e-01
Axon guidance 457 1.28e-05 1.19e-01 1.00e-04
Creation of C4 and C2 activators 71 8.33e-02 -1.19e-01 1.47e-01
Regulation of TP53 Activity through Methylation 19 3.70e-01 -1.19e-01 4.78e-01
DAG and IP3 signaling 33 2.39e-01 1.18e-01 3.44e-01
SHC-mediated cascade:FGFR4 10 5.17e-01 1.18e-01 6.25e-01
Mitotic Prophase 98 4.33e-02 1.18e-01 8.69e-02
Protein localization 157 1.07e-02 1.18e-01 2.75e-02
Platelet calcium homeostasis 22 3.38e-01 1.18e-01 4.50e-01
RNA Polymerase I Transcription Termination 27 2.90e-01 -1.18e-01 4.00e-01
Downstream signaling of activated FGFR4 17 4.02e-01 1.17e-01 5.14e-01
Keratan sulfate/keratin metabolism 27 2.91e-01 1.17e-01 4.01e-01
Signaling by NOTCH2 30 2.68e-01 1.17e-01 3.76e-01
Neuronal System 259 1.19e-03 1.17e-01 4.67e-03
Heparan sulfate/heparin (HS-GAG) metabolism 37 2.18e-01 1.17e-01 3.22e-01
ECM proteoglycans 35 2.32e-01 1.17e-01 3.37e-01
Nuclear Envelope (NE) Reassembly 69 9.41e-02 1.17e-01 1.62e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.27e-01 1.16e-01 6.35e-01
Mitotic Anaphase 224 3.35e-03 1.14e-01 1.11e-02
MECP2 regulates neuronal receptors and channels 13 4.78e-01 1.14e-01 5.87e-01
VEGFR2 mediated vascular permeability 27 3.08e-01 1.13e-01 4.19e-01
Nervous system development 476 2.40e-05 1.13e-01 1.75e-04
Antigen processing: Ubiquitination & Proteasome degradation 289 1.01e-03 1.12e-01 4.10e-03
Non-integrin membrane-ECM interactions 37 2.38e-01 1.12e-01 3.43e-01
Initial triggering of complement 78 8.68e-02 -1.12e-01 1.51e-01
Molecules associated with elastic fibres 22 3.63e-01 1.12e-01 4.71e-01
RNA polymerase II transcribes snRNA genes 72 1.01e-01 1.12e-01 1.69e-01
Formation of TC-NER Pre-Incision Complex 53 1.61e-01 1.11e-01 2.47e-01
PI Metabolism 80 8.53e-02 1.11e-01 1.50e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 4.56e-01 1.11e-01 5.66e-01
Interleukin-20 family signaling 17 4.30e-01 1.11e-01 5.41e-01
Ca2+ pathway 57 1.50e-01 1.10e-01 2.33e-01
Phase I - Functionalization of compounds 65 1.24e-01 1.10e-01 1.99e-01
Metabolism of nucleotides 86 7.90e-02 1.10e-01 1.41e-01
Mitotic Metaphase and Anaphase 225 4.82e-03 1.09e-01 1.48e-02
Adherens junctions interactions 19 4.11e-01 1.09e-01 5.22e-01
Glucose metabolism 84 8.62e-02 1.08e-01 1.51e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 4.70e-01 -1.08e-01 5.79e-01
Assembly and cell surface presentation of NMDA receptors 18 4.29e-01 -1.08e-01 5.41e-01
SHC-mediated cascade:FGFR1 12 5.19e-01 1.07e-01 6.27e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 2.54e-01 -1.07e-01 3.61e-01
Cytokine Signaling in Immune system 736 8.01e-07 1.07e-01 1.03e-05
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 2.32e-01 1.07e-01 3.37e-01
HIV Transcription Elongation 42 2.32e-01 1.07e-01 3.37e-01
Tat-mediated elongation of the HIV-1 transcript 42 2.32e-01 1.07e-01 3.37e-01
Chromosome Maintenance 105 5.92e-02 -1.07e-01 1.12e-01
Glycolysis 67 1.32e-01 1.06e-01 2.10e-01
Phase II - Conjugation of compounds 67 1.34e-01 1.06e-01 2.13e-01
Role of phospholipids in phagocytosis 88 8.64e-02 -1.06e-01 1.51e-01
G alpha (i) signalling events 245 4.53e-03 1.05e-01 1.41e-02
The phototransduction cascade 26 3.54e-01 -1.05e-01 4.63e-01
PI-3K cascade:FGFR4 10 5.65e-01 1.05e-01 6.67e-01
Activation of NMDA receptors and postsynaptic events 58 1.69e-01 1.04e-01 2.58e-01
Cellular hexose transport 15 4.86e-01 -1.04e-01 5.94e-01
FCERI mediated NF-kB activation 138 3.53e-02 1.04e-01 7.29e-02
Signaling by FGFR2 60 1.65e-01 1.04e-01 2.53e-01
PI3K/AKT Signaling in Cancer 81 1.08e-01 1.03e-01 1.79e-01
RUNX2 regulates osteoblast differentiation 19 4.36e-01 -1.03e-01 5.45e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 2.38e-01 1.03e-01 3.43e-01
Acetylcholine Neurotransmitter Release Cycle 11 5.55e-01 -1.03e-01 6.60e-01
Generic Transcription Pathway 1085 1.09e-08 -1.03e-01 2.25e-07
Mitochondrial calcium ion transport 22 4.05e-01 1.03e-01 5.16e-01
Regulation of TP53 Activity 152 2.96e-02 -1.02e-01 6.37e-02
SLC-mediated transmembrane transport 180 1.84e-02 1.02e-01 4.27e-02
Gene expression (Transcription) 1332 5.27e-10 -1.01e-01 1.39e-08
DNA Double-Strand Break Repair 135 4.22e-02 -1.01e-01 8.50e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 5.47e-01 1.01e-01 6.53e-01
Interleukin receptor SHC signaling 23 4.04e-01 1.00e-01 5.16e-01
Transcriptional activation of mitochondrial biogenesis 51 2.20e-01 9.92e-02 3.24e-01
Post NMDA receptor activation events 48 2.36e-01 9.88e-02 3.41e-01
Interconversion of nucleotide di- and triphosphates 27 3.75e-01 9.87e-02 4.83e-01
Cilium Assembly 180 2.26e-02 -9.85e-02 5.10e-02
Switching of origins to a post-replicative state 90 1.07e-01 9.84e-02 1.78e-01
Condensation of Prometaphase Chromosomes 11 5.73e-01 9.81e-02 6.76e-01
Biological oxidations 137 4.75e-02 9.81e-02 9.39e-02
Regulation of KIT signaling 15 5.12e-01 9.79e-02 6.20e-01
Glutamate and glutamine metabolism 12 5.61e-01 -9.69e-02 6.65e-01
Nicotinamide salvaging 14 5.31e-01 -9.67e-02 6.38e-01
PI-3K cascade:FGFR1 12 5.63e-01 9.63e-02 6.66e-01
Endosomal/Vacuolar pathway 12 5.63e-01 -9.63e-02 6.66e-01
Downstream signaling of activated FGFR1 20 4.62e-01 9.49e-02 5.72e-01
IGF1R signaling cascade 36 3.24e-01 9.49e-02 4.38e-01
N-Glycan antennae elongation 13 5.54e-01 -9.48e-02 6.60e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 1.62e-01 9.47e-02 2.49e-01
Cytochrome P450 - arranged by substrate type 36 3.28e-01 9.43e-02 4.40e-01
Diseases associated with glycosaminoglycan metabolism 26 4.08e-01 9.38e-02 5.19e-01
Separation of Sister Chromatids 168 3.62e-02 9.36e-02 7.41e-02
Interleukin-2 family signaling 38 3.19e-01 9.35e-02 4.31e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 2.74e-01 9.31e-02 3.85e-01
Positive epigenetic regulation of rRNA expression 59 2.16e-01 9.31e-02 3.19e-01
Cholesterol biosynthesis 24 4.30e-01 9.30e-02 5.41e-01
HSF1 activation 26 4.12e-01 9.30e-02 5.23e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 4.43e-01 9.25e-02 5.52e-01
G alpha (q) signalling events 134 6.48e-02 9.24e-02 1.20e-01
Signaling by FGFR 69 1.85e-01 9.23e-02 2.81e-01
Regulation of TP53 Activity through Phosphorylation 88 1.35e-01 -9.21e-02 2.15e-01
Nuclear Envelope Breakdown 53 2.46e-01 -9.20e-02 3.53e-01
Synthesis of IP3 and IP4 in the cytosol 22 4.56e-01 9.17e-02 5.66e-01
mRNA Capping 29 3.97e-01 9.08e-02 5.09e-01
DNA Damage Bypass 47 2.82e-01 -9.07e-02 3.91e-01
RNA Polymerase III Abortive And Retractive Initiation 41 3.15e-01 -9.06e-02 4.27e-01
RNA Polymerase III Transcription 41 3.15e-01 -9.06e-02 4.27e-01
Acyl chain remodelling of PS 14 5.59e-01 9.02e-02 6.63e-01
Mitotic G2-G2/M phases 182 3.62e-02 9.00e-02 7.41e-02
STING mediated induction of host immune responses 15 5.48e-01 8.96e-02 6.53e-01
Homology Directed Repair 110 1.07e-01 -8.89e-02 1.79e-01
M Phase 360 3.81e-03 8.88e-02 1.22e-02
Lysine catabolism 11 6.10e-01 8.87e-02 7.09e-01
Metabolism of RNA 688 7.82e-05 -8.83e-02 4.70e-04
Purine catabolism 16 5.42e-01 8.80e-02 6.48e-01
RNA Polymerase II Transcription 1204 4.09e-07 -8.67e-02 5.95e-06
NCAM signaling for neurite out-growth 43 3.26e-01 -8.66e-02 4.39e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 3.69e-01 8.65e-02 4.78e-01
Nonhomologous End-Joining (NHEJ) 42 3.36e-01 8.58e-02 4.47e-01
Inositol phosphate metabolism 42 3.38e-01 8.54e-02 4.50e-01
Signaling by the B Cell Receptor (BCR) 163 6.05e-02 8.52e-02 1.13e-01
Peptide ligand-binding receptors 97 1.47e-01 8.52e-02 2.30e-01
Transcription of the HIV genome 67 2.28e-01 8.51e-02 3.33e-01
Activation of BH3-only proteins 30 4.22e-01 8.48e-02 5.34e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 4.76e-01 8.40e-02 5.85e-01
Processing of Intronless Pre-mRNAs 19 5.28e-01 -8.37e-02 6.35e-01
Nephrin family interactions 18 5.40e-01 -8.33e-02 6.46e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 4.90e-01 8.31e-02 5.96e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 6.04e-01 8.31e-02 7.03e-01
Signaling by WNT in cancer 30 4.31e-01 8.30e-02 5.41e-01
Prolactin receptor signaling 11 6.33e-01 8.30e-02 7.28e-01
IRS-related events triggered by IGF1R 35 3.95e-01 8.30e-02 5.07e-01
G2/M Transition 180 5.50e-02 8.29e-02 1.05e-01
Fertilization 12 6.19e-01 8.29e-02 7.15e-01
G1/S-Specific Transcription 29 4.40e-01 -8.28e-02 5.49e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 10 6.50e-01 -8.28e-02 7.45e-01
NRAGE signals death through JNK 53 3.03e-01 8.19e-02 4.13e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 5.60e-01 -8.16e-02 6.64e-01
DNA Repair 289 1.71e-02 -8.15e-02 4.04e-02
Elevation of cytosolic Ca2+ levels 13 6.11e-01 8.15e-02 7.09e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 3.16e-01 -8.11e-02 4.28e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 6.43e-01 -8.08e-02 7.38e-01
Host Interactions of HIV factors 130 1.12e-01 8.07e-02 1.83e-01
TNFs bind their physiological receptors 25 4.86e-01 -8.06e-02 5.94e-01
DNA Double Strand Break Response 47 3.40e-01 8.05e-02 4.50e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 3.91e-01 8.04e-02 5.03e-01
Regulation of HSF1-mediated heat shock response 79 2.22e-01 -7.94e-02 3.26e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 5.71e-01 -7.93e-02 6.74e-01
PKMTs methylate histone lysines 45 3.58e-01 -7.92e-02 4.65e-01
Olfactory Signaling Pathway 60 2.89e-01 7.91e-02 3.99e-01
GPCR downstream signalling 500 2.69e-03 7.84e-02 9.22e-03
Interleukin-7 signaling 21 5.38e-01 7.76e-02 6.44e-01
Signaling by GPCR 545 2.12e-03 7.69e-02 7.51e-03
Sema3A PAK dependent Axon repulsion 16 5.96e-01 7.66e-02 6.95e-01
ADORA2B mediated anti-inflammatory cytokines production 73 2.62e-01 7.60e-02 3.71e-01
Recruitment of NuMA to mitotic centrosomes 79 2.44e-01 -7.58e-02 3.50e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 5.89e-01 -7.56e-02 6.91e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 5.13e-01 7.56e-02 6.21e-01
TICAM1-dependent activation of IRF3/IRF7 12 6.52e-01 7.51e-02 7.47e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 6.66e-01 -7.51e-02 7.56e-01
Transcriptional regulation by small RNAs 63 3.04e-01 7.49e-02 4.14e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 6.55e-01 7.46e-02 7.49e-01
FCERI mediated Ca+2 mobilization 89 2.26e-01 -7.42e-02 3.31e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 5.22e-01 -7.40e-02 6.29e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 37 4.36e-01 7.39e-02 5.45e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 5.78e-01 -7.36e-02 6.81e-01
Signaling by NTRK3 (TRKC) 16 6.13e-01 7.29e-02 7.10e-01
Neurotransmitter release cycle 39 4.31e-01 7.29e-02 5.41e-01
Cell-cell junction organization 39 4.31e-01 7.29e-02 5.41e-01
TCR signaling 122 1.65e-01 7.28e-02 2.52e-01
TRP channels 19 5.83e-01 -7.28e-02 6.85e-01
Regulation of RUNX1 Expression and Activity 18 5.97e-01 -7.20e-02 6.96e-01
Adaptive Immune System 757 7.74e-04 7.18e-02 3.30e-03
Centrosome maturation 80 2.68e-01 -7.17e-02 3.76e-01
Recruitment of mitotic centrosome proteins and complexes 80 2.68e-01 -7.17e-02 3.76e-01
Ovarian tumor domain proteases 37 4.53e-01 7.13e-02 5.63e-01
Downstream TCR signaling 101 2.16e-01 7.12e-02 3.19e-01
MicroRNA (miRNA) biogenesis 24 5.54e-01 6.97e-02 6.60e-01
FCGR3A-mediated IL10 synthesis 99 2.34e-01 -6.92e-02 3.39e-01
RNA Polymerase I Promoter Clearance 63 3.43e-01 6.91e-02 4.52e-01
RNA Polymerase I Transcription 63 3.43e-01 6.91e-02 4.52e-01
Anchoring of the basal body to the plasma membrane 96 2.48e-01 -6.82e-02 3.54e-01
Cellular response to heat stress 93 2.59e-01 -6.78e-02 3.67e-01
Establishment of Sister Chromatid Cohesion 11 6.97e-01 6.78e-02 7.86e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 63 3.59e-01 6.68e-02 4.66e-01
G alpha (s) signalling events 143 1.69e-01 6.66e-02 2.58e-01
Cyclin D associated events in G1 47 4.33e-01 6.61e-02 5.43e-01
G1 Phase 47 4.33e-01 6.61e-02 5.43e-01
Signaling by FGFR4 in disease 11 7.05e-01 6.59e-02 7.93e-01
TRAF6 mediated IRF7 activation 15 6.59e-01 6.59e-02 7.52e-01
IRS-mediated signalling 34 5.09e-01 6.55e-02 6.16e-01
Scavenging of heme from plasma 71 3.41e-01 -6.53e-02 4.51e-01
Pregnenolone biosynthesis 10 7.23e-01 6.47e-02 8.06e-01
SUMOylation of transcription cofactors 44 4.59e-01 6.45e-02 5.68e-01
WNT ligand biogenesis and trafficking 21 6.10e-01 6.42e-02 7.09e-01
FGFR2 alternative splicing 25 5.82e-01 6.37e-02 6.84e-01
Interleukin-37 signaling 19 6.31e-01 6.36e-02 7.26e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 2.63e-01 -6.36e-02 3.71e-01
Xenobiotics 12 7.03e-01 -6.35e-02 7.91e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 4.72e-01 6.34e-02 5.81e-01
Synthesis, secretion, and deacylation of Ghrelin 11 7.16e-01 -6.33e-02 8.01e-01
Base Excision Repair 58 4.05e-01 -6.32e-02 5.16e-01
Basigin interactions 23 6.01e-01 6.31e-02 7.00e-01
Late Phase of HIV Life Cycle 131 2.13e-01 6.30e-02 3.16e-01
Processing and activation of SUMO 10 7.35e-01 6.17e-02 8.15e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 7.13e-01 -6.13e-02 7.99e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 4.25e-01 6.11e-02 5.37e-01
Constitutive Signaling by Aberrant PI3K in Cancer 54 4.44e-01 6.02e-02 5.53e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 4.74e-01 5.97e-02 5.83e-01
Regulation of TNFR1 signaling 34 5.47e-01 -5.97e-02 6.53e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 5.92e-01 5.96e-02 6.93e-01
Receptor-type tyrosine-protein phosphatases 12 7.24e-01 5.89e-02 8.06e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 3.51e-01 -5.89e-02 4.61e-01
NOTCH4 Intracellular Domain Regulates Transcription 18 6.67e-01 5.87e-02 7.56e-01
Transcriptional Regulation by VENTX 38 5.38e-01 -5.77e-02 6.44e-01
Diseases associated with N-glycosylation of proteins 17 6.85e-01 5.69e-02 7.75e-01
PI3K Cascade 30 5.90e-01 5.69e-02 6.91e-01
Regulation of PTEN mRNA translation 13 7.23e-01 -5.67e-02 8.06e-01
PERK regulates gene expression 31 5.86e-01 5.66e-02 6.87e-01
Branched-chain amino acid catabolism 21 6.58e-01 -5.57e-02 7.52e-01
G2/M Checkpoints 140 2.68e-01 5.42e-02 3.77e-01
Translation 295 1.10e-01 -5.41e-02 1.81e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 80 4.08e-01 5.35e-02 5.19e-01
Other interleukin signaling 18 6.95e-01 5.34e-02 7.84e-01
PI-3K cascade:FGFR2 12 7.50e-01 -5.32e-02 8.26e-01
SUMOylation 166 2.45e-01 -5.23e-02 3.52e-01
Synthesis of PIPs at the Golgi membrane 16 7.21e-01 5.16e-02 8.05e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 6.03e-01 5.15e-02 7.02e-01
Processing of SMDT1 15 7.30e-01 5.14e-02 8.12e-01
Eicosanoid ligand-binding receptors 13 7.48e-01 -5.14e-02 8.26e-01
O-linked glycosylation 83 4.27e-01 -5.05e-02 5.39e-01
CD28 co-stimulation 33 6.17e-01 -5.03e-02 7.13e-01
Cargo trafficking to the periciliary membrane 47 5.63e-01 4.88e-02 6.66e-01
Role of LAT2/NTAL/LAB on calcium mobilization 74 4.69e-01 -4.87e-02 5.79e-01
Signaling by NODAL 13 7.62e-01 -4.86e-02 8.34e-01
Loss of Nlp from mitotic centrosomes 68 4.90e-01 -4.84e-02 5.96e-01
Loss of proteins required for interphase microtubule organization from the centrosome 68 4.90e-01 -4.84e-02 5.96e-01
Association of TriC/CCT with target proteins during biosynthesis 37 6.11e-01 4.83e-02 7.09e-01
TRAF3-dependent IRF activation pathway 13 7.63e-01 4.82e-02 8.36e-01
TP53 Regulates Transcription of DNA Repair Genes 61 5.20e-01 -4.76e-02 6.27e-01
Processing of Capped Intronless Pre-mRNA 28 6.63e-01 -4.76e-02 7.55e-01
mRNA Splicing - Minor Pathway 52 5.56e-01 4.72e-02 6.61e-01
Neurexins and neuroligins 37 6.21e-01 -4.70e-02 7.16e-01
Chromatin modifying enzymes 218 2.34e-01 4.67e-02 3.39e-01
Chromatin organization 218 2.34e-01 4.67e-02 3.39e-01
HIV Life Cycle 144 3.39e-01 4.61e-02 4.50e-01
Phosphorylation of the APC/C 20 7.21e-01 4.61e-02 8.05e-01
Mitotic Prometaphase 184 2.83e-01 -4.59e-02 3.92e-01
Telomere Maintenance 80 4.88e-01 -4.48e-02 5.96e-01
Ion transport by P-type ATPases 43 6.12e-01 4.47e-02 7.09e-01
SUMO E3 ligases SUMOylate target proteins 160 3.33e-01 -4.44e-02 4.45e-01
Reproduction 80 4.93e-01 4.43e-02 5.99e-01
Glucagon-type ligand receptors 20 7.32e-01 4.42e-02 8.12e-01
DNA Replication Pre-Initiation 83 4.87e-01 4.42e-02 5.94e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 4.86e-01 -4.40e-02 5.94e-01
Signaling by FGFR2 in disease 32 6.67e-01 4.39e-02 7.56e-01
Defective B4GALT7 causes EDS, progeroid type 11 8.02e-01 -4.37e-02 8.66e-01
Netrin-1 signaling 40 6.38e-01 4.30e-02 7.33e-01
RNA Polymerase III Transcription Termination 23 7.25e-01 -4.24e-02 8.06e-01
DAP12 signaling 28 6.98e-01 4.23e-02 7.87e-01
Regulation of expression of SLITs and ROBOs 161 3.55e-01 -4.22e-02 4.64e-01
SHC-mediated cascade:FGFR2 12 8.01e-01 -4.21e-02 8.66e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 7.45e-01 -4.20e-02 8.24e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 8.02e-01 4.18e-02 8.66e-01
Transcriptional Regulation by TP53 352 1.82e-01 4.14e-02 2.77e-01
Diseases of metabolism 190 3.27e-01 4.12e-02 4.39e-01
Norepinephrine Neurotransmitter Release Cycle 14 7.92e-01 4.07e-02 8.61e-01
Signaling by KIT in disease 20 7.56e-01 -4.01e-02 8.30e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 7.56e-01 -4.01e-02 8.30e-01
Glutamate Neurotransmitter Release Cycle 20 7.57e-01 -4.00e-02 8.30e-01
IL-6-type cytokine receptor ligand interactions 12 8.11e-01 3.98e-02 8.74e-01
Lewis blood group biosynthesis 13 8.04e-01 3.97e-02 8.68e-01
CDC6 association with the ORC:origin complex 11 8.20e-01 -3.95e-02 8.82e-01
Formation of Incision Complex in GG-NER 43 6.56e-01 3.93e-02 7.50e-01
SUMOylation of DNA methylation proteins 16 7.86e-01 -3.91e-02 8.57e-01
Sulfur amino acid metabolism 22 7.53e-01 3.88e-02 8.28e-01
Interleukin-2 signaling 11 8.25e-01 3.84e-02 8.87e-01
Meiosis 68 5.93e-01 3.75e-02 6.93e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 5.38e-01 -3.74e-02 6.44e-01
Amplification of signal from the kinetochores 91 5.38e-01 -3.74e-02 6.44e-01
mRNA 3’-end processing 56 6.29e-01 -3.73e-02 7.25e-01
TNFR1-induced NFkappaB signaling pathway 25 7.50e-01 -3.68e-02 8.26e-01
Cytosolic sensors of pathogen-associated DNA 62 6.19e-01 3.65e-02 7.15e-01
Termination of O-glycan biosynthesis 16 8.02e-01 3.63e-02 8.66e-01
Mitochondrial protein import 64 6.19e-01 3.59e-02 7.15e-01
Deactivation of the beta-catenin transactivating complex 36 7.10e-01 3.58e-02 7.96e-01
Synthesis of DNA 119 5.06e-01 -3.53e-02 6.14e-01
CLEC7A (Dectin-1) induces NFAT activation 11 8.40e-01 -3.52e-02 8.97e-01
S Phase 161 4.47e-01 -3.48e-02 5.56e-01
Class A/1 (Rhodopsin-like receptors) 169 4.36e-01 3.47e-02 5.45e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 8.42e-01 3.47e-02 8.99e-01
Metabolism of water-soluble vitamins and cofactors 110 5.37e-01 -3.41e-02 6.44e-01
Processing of Capped Intron-Containing Pre-mRNA 238 3.66e-01 -3.40e-02 4.73e-01
Mitotic G1 phase and G1/S transition 148 4.86e-01 3.32e-02 5.94e-01
Metabolism of vitamins and cofactors 156 4.76e-01 3.31e-02 5.85e-01
Vitamin D (calciferol) metabolism 10 8.57e-01 3.29e-02 9.04e-01
IRF3-mediated induction of type I IFN 12 8.44e-01 -3.29e-02 8.99e-01
PIWI-interacting RNA (piRNA) biogenesis 24 7.81e-01 3.28e-02 8.53e-01
Visual phototransduction 60 6.65e-01 3.23e-02 7.56e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 8.38e-01 -3.16e-02 8.96e-01
Nucleotide-like (purinergic) receptors 13 8.44e-01 3.15e-02 8.99e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 7.45e-01 -3.13e-02 8.24e-01
Diseases of mitotic cell cycle 36 7.45e-01 -3.13e-02 8.24e-01
Mitotic Spindle Checkpoint 108 5.80e-01 -3.08e-02 6.82e-01
Processing of DNA double-strand break ends 71 6.59e-01 -3.03e-02 7.52e-01
TNF signaling 43 7.31e-01 3.03e-02 8.12e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 8.45e-01 -3.02e-02 9.00e-01
Signaling by Retinoic Acid 31 7.73e-01 3.00e-02 8.45e-01
GABA synthesis, release, reuptake and degradation 13 8.52e-01 -2.98e-02 9.01e-01
Voltage gated Potassium channels 25 7.97e-01 2.97e-02 8.65e-01
AURKA Activation by TPX2 71 6.66e-01 -2.96e-02 7.56e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 8.34e-01 -2.94e-02 8.93e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 8.34e-01 -2.94e-02 8.93e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 8.54e-01 2.85e-02 9.01e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 8.54e-01 2.85e-02 9.01e-01
G2/M DNA damage checkpoint 68 6.86e-01 -2.84e-02 7.75e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 6.95e-01 -2.84e-02 7.84e-01
RNA Polymerase II Transcription Termination 65 6.95e-01 -2.81e-02 7.84e-01
Serotonin Neurotransmitter Release Cycle 15 8.50e-01 2.81e-02 9.01e-01
Activation of SMO 13 8.65e-01 2.73e-02 9.10e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 7.77e-01 2.73e-02 8.49e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 8.32e-01 -2.68e-02 8.92e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 8.32e-01 -2.68e-02 8.92e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 8.58e-01 -2.59e-02 9.04e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 8.40e-01 -2.54e-02 8.97e-01
Epigenetic regulation of gene expression 100 6.61e-01 2.54e-02 7.53e-01
APC-Cdc20 mediated degradation of Nek2A 26 8.37e-01 2.34e-02 8.96e-01
Ribosomal scanning and start codon recognition 58 7.59e-01 -2.33e-02 8.32e-01
Interaction between L1 and Ankyrins 22 8.50e-01 2.33e-02 9.01e-01
Deposition of new CENPA-containing nucleosomes at the centromere 40 8.00e-01 2.32e-02 8.66e-01
Nucleosome assembly 40 8.00e-01 2.32e-02 8.66e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 8.69e-01 -2.32e-02 9.13e-01
FGFR2 mutant receptor activation 22 8.51e-01 2.31e-02 9.01e-01
Interleukin-35 Signalling 12 8.91e-01 -2.29e-02 9.32e-01
DNA Replication 126 6.64e-01 -2.24e-02 7.55e-01
Binding and Uptake of Ligands by Scavenger Receptors 93 7.09e-01 2.24e-02 7.96e-01
Regulation of Complement cascade 95 7.15e-01 -2.17e-02 8.00e-01
Complement cascade 99 7.15e-01 -2.12e-02 8.00e-01
Class B/2 (Secretin family receptors) 56 7.84e-01 2.11e-02 8.56e-01
Methylation 12 8.99e-01 -2.11e-02 9.38e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 8.65e-01 2.10e-02 9.10e-01
G0 and Early G1 27 8.52e-01 2.08e-02 9.01e-01
Cell Cycle, Mitotic 502 4.26e-01 2.07e-02 5.38e-01
GPCR ligand binding 235 5.92e-01 2.03e-02 6.93e-01
RHO GTPases Activate Formins 117 7.09e-01 2.00e-02 7.96e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 8.98e-01 1.99e-02 9.37e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 9.10e-01 -1.97e-02 9.43e-01
Regulation of innate immune responses to cytosolic DNA 14 8.99e-01 1.96e-02 9.38e-01
Synthesis of PA 32 8.50e-01 1.94e-02 9.01e-01
Signaling by BMP 21 8.81e-01 -1.89e-02 9.23e-01
EML4 and NUDC in mitotic spindle formation 95 7.52e-01 -1.87e-02 8.28e-01
RUNX2 regulates bone development 24 8.75e-01 -1.85e-02 9.19e-01
Signaling by FGFR3 in disease 13 9.08e-01 1.84e-02 9.43e-01
Signaling by FGFR3 point mutants in cancer 13 9.08e-01 1.84e-02 9.43e-01
Translation initiation complex formation 58 8.09e-01 -1.83e-02 8.73e-01
HCMV Early Events 74 7.91e-01 1.78e-02 8.61e-01
Dual incision in TC-NER 65 8.15e-01 -1.67e-02 8.78e-01
Cell Cycle Checkpoints 260 6.48e-01 1.65e-02 7.43e-01
Downstream signaling of activated FGFR2 19 9.03e-01 1.62e-02 9.41e-01
HATs acetylate histones 93 7.88e-01 -1.61e-02 8.58e-01
AKT phosphorylates targets in the nucleus 10 9.31e-01 -1.58e-02 9.54e-01
FCERI mediated MAPK activation 90 7.97e-01 1.57e-02 8.65e-01
CRMPs in Sema3A signaling 14 9.19e-01 -1.56e-02 9.50e-01
FRS-mediated FGFR2 signaling 14 9.20e-01 1.56e-02 9.50e-01
Lysosphingolipid and LPA receptors 11 9.30e-01 -1.52e-02 9.54e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.08e-01 -1.50e-02 9.43e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.08e-01 1.49e-02 9.43e-01
Keratan sulfate biosynthesis 22 9.04e-01 -1.49e-02 9.41e-01
Negative regulators of DDX58/IFIH1 signaling 34 8.90e-01 -1.37e-02 9.32e-01
Regulation of TP53 Expression and Degradation 36 8.93e-01 -1.30e-02 9.33e-01
CTLA4 inhibitory signaling 21 9.19e-01 -1.29e-02 9.50e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 9.44e-01 1.29e-02 9.62e-01
Defective EXT2 causes exostoses 2 10 9.44e-01 1.29e-02 9.62e-01
Transcription of E2F targets under negative control by DREAM complex 19 9.26e-01 1.23e-02 9.53e-01
FOXO-mediated transcription of cell cycle genes 15 9.36e-01 1.19e-02 9.58e-01
Regulation of PLK1 Activity at G2/M Transition 86 8.52e-01 -1.16e-02 9.01e-01
Dopamine Neurotransmitter Release Cycle 20 9.29e-01 1.15e-02 9.53e-01
Nicotinate metabolism 25 9.21e-01 -1.15e-02 9.50e-01
Organelle biogenesis and maintenance 268 7.48e-01 -1.14e-02 8.26e-01
Diseases of glycosylation 108 8.47e-01 -1.07e-02 9.01e-01
Signaling by ROBO receptors 201 7.93e-01 -1.07e-02 8.62e-01
Mitochondrial translation termination 91 8.68e-01 -1.01e-02 9.13e-01
CASP8 activity is inhibited 11 9.55e-01 -9.91e-03 9.67e-01
Dimerization of procaspase-8 11 9.55e-01 -9.91e-03 9.67e-01
Regulation by c-FLIP 11 9.55e-01 -9.91e-03 9.67e-01
DNA Damage Recognition in GG-NER 38 9.16e-01 -9.86e-03 9.48e-01
Mitochondrial translation elongation 91 8.78e-01 -9.27e-03 9.22e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 9.54e-01 -8.64e-03 9.67e-01
Deadenylation-dependent mRNA decay 53 9.16e-01 -8.41e-03 9.48e-01
Synthesis of PIPs at the early endosome membrane 16 9.54e-01 -8.25e-03 9.67e-01
Regulation of FZD by ubiquitination 15 9.56e-01 -8.14e-03 9.68e-01
Nucleotide Excision Repair 110 8.85e-01 -8.00e-03 9.27e-01
PECAM1 interactions 12 9.62e-01 -7.90e-03 9.71e-01
Cell Cycle 624 7.42e-01 -7.73e-03 8.22e-01
RMTs methylate histone arginines 37 9.37e-01 7.53e-03 9.58e-01
Tight junction interactions 18 9.57e-01 7.28e-03 9.68e-01
Defective B3GAT3 causes JDSSDHD 11 9.69e-01 -6.88e-03 9.76e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 9.50e-01 6.49e-03 9.67e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 9.33e-01 -6.36e-03 9.55e-01
Metabolism of amino acids and derivatives 326 8.50e-01 -6.08e-03 9.01e-01
Regulation of TP53 Degradation 35 9.51e-01 6.03e-03 9.67e-01
Cardiac conduction 86 9.24e-01 5.96e-03 9.52e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 9.29e-01 -5.87e-03 9.53e-01
G1/S Transition 130 9.10e-01 5.77e-03 9.43e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 9.72e-01 5.64e-03 9.79e-01
Collagen chain trimerization 27 9.60e-01 5.54e-03 9.70e-01
Resolution of Sister Chromatid Cohesion 104 9.23e-01 -5.49e-03 9.52e-01
Mitochondrial translation initiation 91 9.42e-01 -4.45e-03 9.61e-01
Mitochondrial translation 97 9.40e-01 4.40e-03 9.61e-01
Kinesins 39 9.64e-01 4.16e-03 9.73e-01
Anti-inflammatory response favouring Leishmania parasite infection 169 9.27e-01 4.07e-03 9.53e-01
Leishmania parasite growth and survival 169 9.27e-01 4.07e-03 9.53e-01
SLC transporter disorders 77 9.52e-01 3.97e-03 9.67e-01
Synaptic adhesion-like molecules 15 9.79e-01 3.89e-03 9.85e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 9.78e-01 -3.15e-03 9.84e-01
mRNA Splicing - Major Pathway 179 9.58e-01 -2.29e-03 9.68e-01
DCC mediated attractive signaling 13 9.92e-01 1.61e-03 9.96e-01
Protein-protein interactions at synapses 58 9.88e-01 1.16e-03 9.92e-01
mRNA Splicing 187 9.80e-01 1.05e-03 9.85e-01
Glyoxylate metabolism and glycine degradation 24 9.93e-01 -1.02e-03 9.96e-01
Nuclear Receptor transcription pathway 38 9.93e-01 -7.77e-04 9.96e-01
Gene Silencing by RNA 88 9.96e-01 3.02e-04 9.98e-01
Glutathione synthesis and recycling 10 9.99e-01 -2.37e-04 1.00e+00
Ion homeostasis 41 1.00e+00 -1.34e-05 1.00e+00



Detailed Gene set reports



IRAK4 deficiency (TLR2/4)

IRAK4 deficiency (TLR2/4)
514
set IRAK4 deficiency (TLR2/4)
setSize 10
pANOVA 8.37e-07
s.dist 0.899
p.adjustANOVA 1.05e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD36 9444
TLR2 9103
CD14 9097
TLR4 9016
TLR1 8932
TLR6 8840
LY96 8795
MYD88 8136
BTK 7206
TIRAP 5640

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD36 9444
TLR2 9103
CD14 9097
TLR4 9016
TLR1 8932
TLR6 8840
LY96 8795
MYD88 8136
BTK 7206
TIRAP 5640



MyD88 deficiency (TLR2/4)

MyD88 deficiency (TLR2/4)
687
set MyD88 deficiency (TLR2/4)
setSize 10
pANOVA 8.37e-07
s.dist 0.899
p.adjustANOVA 1.05e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD36 9444
TLR2 9103
CD14 9097
TLR4 9016
TLR1 8932
TLR6 8840
LY96 8795
MYD88 8136
BTK 7206
TIRAP 5640

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD36 9444
TLR2 9103
CD14 9097
TLR4 9016
TLR1 8932
TLR6 8840
LY96 8795
MYD88 8136
BTK 7206
TIRAP 5640



alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
1333
set alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize 12
pANOVA 2.46e-06
s.dist 0.785
p.adjustANOVA 2.63e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACSL1 9217
ACOX1 8859
HSD17B4 8858
ELOVL3 8710
ACAA1 8292
ACOT8 8018
FADS1 7699
ABCD1 7346
ELOVL1 7088
ELOVL5 6011
SCP2 4454
FADS2 1486

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACSL1 9217
ACOX1 8859
HSD17B4 8858
ELOVL3 8710
ACAA1 8292
ACOT8 8018
FADS1 7699
ABCD1 7346
ELOVL1 7088
ELOVL5 6011
SCP2 4454
FADS2 1486



alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism
1334
set alpha-linolenic acid (ALA) metabolism
setSize 12
pANOVA 2.46e-06
s.dist 0.785
p.adjustANOVA 2.63e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACSL1 9217
ACOX1 8859
HSD17B4 8858
ELOVL3 8710
ACAA1 8292
ACOT8 8018
FADS1 7699
ABCD1 7346
ELOVL1 7088
ELOVL5 6011
SCP2 4454
FADS2 1486

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACSL1 9217
ACOX1 8859
HSD17B4 8858
ELOVL3 8710
ACAA1 8292
ACOT8 8018
FADS1 7699
ABCD1 7346
ELOVL1 7088
ELOVL5 6011
SCP2 4454
FADS2 1486



Regulation of TLR by endogenous ligand

Regulation of TLR by endogenous ligand
969
set Regulation of TLR by endogenous ligand
setSize 11
pANOVA 1.93e-05
s.dist 0.744
p.adjustANOVA 0.000145



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A9 9516
S100A8 9503
CD36 9444
TLR2 9103
CD14 9097
TLR4 9016
TLR1 8932
TLR6 8840
LY96 8795
HMGB1 -252
S100A1 -8108

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A9 9516
S100A8 9503
CD36 9444
TLR2 9103
CD14 9097
TLR4 9016
TLR1 8932
TLR6 8840
LY96 8795
HMGB1 -252
S100A1 -8108



Translocation of ZAP-70 to Immunological synapse

Translocation of ZAP-70 to Immunological synapse
1280
set Translocation of ZAP-70 to Immunological synapse
setSize 24
pANOVA 2.81e-10
s.dist -0.744
p.adjustANOVA 8.34e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD247 -12345
HLA-DPA1 -12316
HLA-DPB1 -12248
HLA-DRA -12009
TRBC1 -12006
HLA-DQA1 -11992
ZAP70 -11949
LCK -11838
CD3G -11526
TRAC -11482
CD3D -11401
CD3E -11302
TRBV12-3 -10436
TRAV19 -9915
TRAV29DV5 -9673
TRBV7-9 -9539
HLA-DQB2 -9401
HLA-DRB1 -8075
TRAV8-4 -7261
HLA-DQB1 -6416

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD247 -12345
HLA-DPA1 -12316
HLA-DPB1 -12248
HLA-DRA -12009
TRBC1 -12006
HLA-DQA1 -11992
ZAP70 -11949
LCK -11838
CD3G -11526
TRAC -11482
CD3D -11401
CD3E -11302
TRBV12-3 -10436
TRAV19 -9915
TRAV29DV5 -9673
TRBV7-9 -9539
HLA-DQB2 -9401
HLA-DRB1 -8075
TRAV8-4 -7261
HLA-DQB1 -6416
CD4 -5406
HLA-DRB5 -4971
HLA-DQA2 -4806
PTPN22 -1208



Hyaluronan uptake and degradation

Hyaluronan uptake and degradation
506
set Hyaluronan uptake and degradation
setSize 12
pANOVA 8.85e-06
s.dist 0.741
p.adjustANOVA 7.24e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHP1 9258
HYAL2 9088
LYVE1 8999
HEXB 8776
CD44 8333
SLC9A1 7969
GUSB 7723
STAB2 5569
HYAL3 5229
HYAL1 4164
HMMR 3808
HEXA 1261

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHP1 9258
HYAL2 9088
LYVE1 8999
HEXB 8776
CD44 8333
SLC9A1 7969
GUSB 7723
STAB2 5569
HYAL3 5229
HYAL1 4164
HMMR 3808
HEXA 1261



Uptake and function of anthrax toxins

Uptake and function of anthrax toxins
1308
set Uptake and function of anthrax toxins
setSize 10
pANOVA 0.000114
s.dist 0.705
p.adjustANOVA 0.000652



Top enriched genes

Top 20 genes
GeneID Gene Rank
FURIN 9075
MAP2K1 9063
MAP2K6 8887
MAP2K3 8748
ANTXR2 7331
MAP2K4 6866
MAP2K2 6794
PDCD6IP 6528
MAP2K7 1654
CALM1 -2081

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FURIN 9075
MAP2K1 9063
MAP2K6 8887
MAP2K3 8748
ANTXR2 7331
MAP2K4 6866
MAP2K2 6794
PDCD6IP 6528
MAP2K7 1654
CALM1 -2081



Erythrocytes take up carbon dioxide and release oxygen

Erythrocytes take up carbon dioxide and release oxygen
346
set Erythrocytes take up carbon dioxide and release oxygen
setSize 11
pANOVA 9.46e-05
s.dist 0.68
p.adjustANOVA 0.000553



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYB5R1 9460
CA1 9380
SLC4A1 9141
HBB 9054
HBA1 8990
CYB5R2 8600
CYB5R4 8421
AQP1 7476
CA2 3570
CA4 2826
CYB5RL -10762

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYB5R1 9460
CA1 9380
SLC4A1 9141
HBB 9054
HBA1 8990
CYB5R2 8600
CYB5R4 8421
AQP1 7476
CA2 3570
CA4 2826
CYB5RL -10762



O2/CO2 exchange in erythrocytes

O2/CO2 exchange in erythrocytes
766
set O2/CO2 exchange in erythrocytes
setSize 11
pANOVA 9.46e-05
s.dist 0.68
p.adjustANOVA 0.000553



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYB5R1 9460
CA1 9380
SLC4A1 9141
HBB 9054
HBA1 8990
CYB5R2 8600
CYB5R4 8421
AQP1 7476
CA2 3570
CA4 2826
CYB5RL -10762

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYB5R1 9460
CA1 9380
SLC4A1 9141
HBB 9054
HBA1 8990
CYB5R2 8600
CYB5R4 8421
AQP1 7476
CA2 3570
CA4 2826
CYB5RL -10762



WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2
1326
set WNT5A-dependent internalization of FZD2, FZD5 and ROR2
setSize 11
pANOVA 0.000117
s.dist 0.671
p.adjustANOVA 0.000658



Top enriched genes

Top 20 genes
GeneID Gene Rank
FZD5 9513
CLTC 9000
AP2M1 8627
CLTA 8376
AP2S1 8026
AP2A2 7257
AP2A1 6832
FZD2 6462
CLTB 6084
ROR1 -2376
AP2B1 -2709

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FZD5 9513
CLTC 9000
AP2M1 8627
CLTA 8376
AP2S1 8026
AP2A2 7257
AP2A1 6832
FZD2 6462
CLTB 6084
ROR1 -2376
AP2B1 -2709



p130Cas linkage to MAPK signaling for integrins

p130Cas linkage to MAPK signaling for integrins
1345
set p130Cas linkage to MAPK signaling for integrins
setSize 11
pANOVA 0.000132
s.dist 0.665
p.adjustANOVA 0.000722



Top enriched genes

Top 20 genes
GeneID Gene Rank
CRK 8906
ITGA2B 8893
APBB1IP 8744
TLN1 8525
ITGB3 8291
FN1 8284
RAP1A 7305
VWF 6641
PTK2 4462
RAP1B 3206
SRC -8820

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRK 8906
ITGA2B 8893
APBB1IP 8744
TLN1 8525
ITGB3 8291
FN1 8284
RAP1A 7305
VWF 6641
PTK2 4462
RAP1B 3206
SRC -8820



Advanced glycosylation endproduct receptor signaling

Advanced glycosylation endproduct receptor signaling
61
set Advanced glycosylation endproduct receptor signaling
setSize 12
pANOVA 9.48e-05
s.dist 0.651
p.adjustANOVA 0.000553



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A12 9515
APP 9177
MAPK3 8953
LGALS3 8752
CAPZA2 8597
CAPZA1 8135
MAPK1 7493
DDOST 6931
PRKCSH 5220
AGER 1294
HMGB1 -252
S100B -5457

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A12 9515
APP 9177
MAPK3 8953
LGALS3 8752
CAPZA2 8597
CAPZA1 8135
MAPK1 7493
DDOST 6931
PRKCSH 5220
AGER 1294
HMGB1 -252
S100B -5457



Unwinding of DNA

Unwinding of DNA
1306
set Unwinding of DNA
setSize 12
pANOVA 0.000132
s.dist -0.637
p.adjustANOVA 0.000722



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM3 -12200
MCM7 -12129
MCM8 -10944
GINS3 -10508
GINS4 -10236
MCM6 -9715
MCM4 -8701
MCM5 -7292
MCM2 -7223
GINS2 -4815
GINS1 -4401
CDC45 -2659

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM3 -12200
MCM7 -12129
MCM8 -10944
GINS3 -10508
GINS4 -10236
MCM6 -9715
MCM4 -8701
MCM5 -7292
MCM2 -7223
GINS2 -4815
GINS1 -4401
CDC45 -2659



RNA Polymerase I Promoter Opening

RNA Polymerase I Promoter Opening
903
set RNA Polymerase I Promoter Opening
setSize 19
pANOVA 3.29e-06
s.dist 0.616
p.adjustANOVA 3.28e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AJ 9374.0
H2BC21 9283.0
H2BC12 9051.0
MAPK3 8953.0
H3-3A 8661.0
H2BC5 8003.0
H2AC6 7934.0
H2BC11 7912.0
H2BC4 7389.0
H2BC17 7285.0
H3C15 6699.5
MBD2 6581.0
H2AZ1 6036.0
H2BC9 5394.0
H2BC15 5312.0
H2AC20 4972.0
H2AZ2 -1209.0
H2BU1 -6555.0
UBTF -10033.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AJ 9374.0
H2BC21 9283.0
H2BC12 9051.0
MAPK3 8953.0
H3-3A 8661.0
H2BC5 8003.0
H2AC6 7934.0
H2BC11 7912.0
H2BC4 7389.0
H2BC17 7285.0
H3C15 6699.5
MBD2 6581.0
H2AZ1 6036.0
H2BC9 5394.0
H2BC15 5312.0
H2AC20 4972.0
H2AZ2 -1209.0
H2BU1 -6555.0
UBTF -10033.0



RHO GTPases Activate WASPs and WAVEs

RHO GTPases Activate WASPs and WAVEs
890
set RHO GTPases Activate WASPs and WAVEs
setSize 35
pANOVA 4.57e-10
s.dist 0.609
p.adjustANOVA 1.33e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
WASF1 9520
GRB2 9304
CYFIP1 9265
ARPC1B 9259
ACTB 9011
MAPK3 8953
ARPC1A 8894
RAC1 8793
ARPC5 8686
ACTG1 8562
WAS 8560
WASF2 8369
ARPC3 8277
ACTR2 7870
ACTR3 7818
NCKAP1L 7673
CDC42 7537
ARPC4 7516
MAPK1 7493
NCKAP1 7462

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WASF1 9520
GRB2 9304
CYFIP1 9265
ARPC1B 9259
ACTB 9011
MAPK3 8953
ARPC1A 8894
RAC1 8793
ARPC5 8686
ACTG1 8562
WAS 8560
WASF2 8369
ARPC3 8277
ACTR2 7870
ACTR3 7818
NCKAP1L 7673
CDC42 7537
ARPC4 7516
MAPK1 7493
NCKAP1 7462
ARPC2 7390
BTK 7206
ABI1 7082
BRK1 7032
WASF3 6808
WIPF2 5713
PTK2 4462
WIPF1 569
NCKIPSD 328
WASL 299
ABL1 226
BAIAP2 -215
CYFIP2 -10367
ABI2 -10915
NCK1 -11454



ROS and RNS production in phagocytes

ROS and RNS production in phagocytes
926
set ROS and RNS production in phagocytes
setSize 31
pANOVA 8.23e-09
s.dist 0.598
p.adjustANOVA 1.76e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP6V0A1 9423
ATP6V1A 9302
NCF4 9268
ATP6V0D1 9245
NCF2 9190
SLC11A1 9169
ATP6V0C 9127
ATP6V1B2 9057
ATP6V1D 9047
CYBB 9031
ATP6V0B 8598
ATP6V0E1 8596
ATP6V1C1 8539
ATP6V1H 8064
ATP6V1E1 8035
MPO 7437
NCF1 7334
TCIRG1 7188
CYBA 6922
LPO 6502

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP6V0A1 9423
ATP6V1A 9302
NCF4 9268
ATP6V0D1 9245
NCF2 9190
SLC11A1 9169
ATP6V0C 9127
ATP6V1B2 9057
ATP6V1D 9047
CYBB 9031
ATP6V0B 8598
ATP6V0E1 8596
ATP6V1C1 8539
ATP6V1H 8064
ATP6V1E1 8035
MPO 7437
NCF1 7334
TCIRG1 7188
CYBA 6922
LPO 6502
ATP6V1F 5878
ATP6V1E2 5730
RAC2 5163
HVCN1 4912
ATP6V1G1 3931
NOS1 1365
NOS3 -2059
ATP6V1C2 -2219
ATP6V1G2 -9515
ATP6V0E2 -11555
ATP6V0A2 -12211



Neutrophil degranulation

Neutrophil degranulation
737
set Neutrophil degranulation
setSize 457
pANOVA 1.32e-103
s.dist 0.587
p.adjustANOVA 1.8e-100



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A9 9516
S100A12 9515
CTSA 9514
SIRPA 9510
IDH1 9507
RNASE2 9506
MCEMP1 9504
S100A8 9503
CD93 9496
CR1 9486
CREG1 9483
MGST1 9482
BST1 9480
TIMP2 9458
HP 9454
CD36 9444
GCA 9436
PGAM1 9435
SERPINB1 9434
CTSD 9433

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A9 9516
S100A12 9515
CTSA 9514
SIRPA 9510
IDH1 9507
RNASE2 9506
MCEMP1 9504
S100A8 9503
CD93 9496
CR1 9486
CREG1 9483
MGST1 9482
BST1 9480
TIMP2 9458
HP 9454
CD36 9444
GCA 9436
PGAM1 9435
SERPINB1 9434
CTSD 9433
ATP6V0A1 9423
PYGL 9417
LAMTOR1 9411
ITGAM 9398
PKM 9391
DOK3 9388
HK3 9385
SIGLEC9 9383
CKAP4 9370
CTSB 9364
GNS 9360
RAB31 9356
PTAFR 9355
ANPEP 9350
PGM2 9344
QPCT 9327
SDCBP 9311
CDA 9310
GRN 9308
PLD1 9306
QSOX1 9298
FPR1 9295
IMPDH1 9294
CD63 9287
MNDA 9277
VAT1 9276
CYFIP1 9265
LTA4H 9261
PADI2 9257
AGPAT2 9256
ALDOA 9249
MMP8 9232
RAB3D 9207
TOM1 9200
NCSTN 9186
CLEC4D 9185
SLC11A1 9169
SERPINA1 9168
CD55 9145
GPR84 9133
C5AR1 9129
ATP6V0C 9127
CAT 9123
FCN1 9113
FCAR 9111
CRISPLD2 9106
MAPK14 9104
TLR2 9103
TRPM2 9102
CD14 9097
FPR2 9095
VNN1 9092
NFAM1 9086
CYSTM1 9077
OSCAR 9068
GM2A 9059
HBB 9054
MGAM 9050
ATP6V1D 9047
VAPA 9033
CYBB 9031
NEU1 9029
SLC2A3 9021
BRI3 9017
APAF1 9015
GYG1 9013
PRKCD 9008
ALOX5 9001
RETN 8998
CTSZ 8975
S100A11 8946
ITGB2 8942
PRDX6 8937
SERPINB10 8933
RAB10 8926
SELL 8912
CYB5R3 8903
LILRB3 8871
FCGR2A 8845
RAC1 8793
ADAM10 8791
LAMP2 8786
HEXB 8776
ARG1 8759
LGALS3 8752
GSN 8749
RAB7A 8742
TNFAIP6 8738
AMPD3 8732
GLB1 8725
OLFM4 8724
ARPC5 8686
DNAJC5 8679
LRG1 8674
FTL 8665
ALDH3B1 8663
RAB5C 8655
PYCARD 8638
PDXK 8635
DNASE1L1 8632
SNAP23 8628
TOLLIP 8572
GLA 8570
CAPN1 8563
ANXA2 8544
CD68 8533
ASAH1 8529
MMP25 8515
ALAD 8514
DERA 8500
RHOG 8487
PSMB7 8485
FGR 8478
HPSE 8476
CLEC5A 8473
PLAC8 8452
P2RX1 8436
DNAJC3 8435
CEACAM1 8429
PLAUR 8424
PNP 8419
RAB27A 8411
HEBP2 8398
ATP11A 8394
CTSS 8372
TMBIM1 8361
CPPED1 8357
CD44 8333
S100P 8331
RHOA 8319
FUCA2 8304
ACAA1 8292
CAB39 8276
DNAJC13 8263
GMFG 8259
MOSPD2 8252
ARL8A 8249
PRCP 8218
ADGRG3 8204
SIGLEC5 8161
IQGAP1 8152
RAB6A 8148
ATG7 8134
RAB3A 8133
FCER1G 8131
CAP1 8111
HSPA1A 8071
CD33 8069
PLEKHO2 8059
LILRB2 8057
ANO6 8048
TMEM30A 8036
ATP6AP2 8034
C3AR1 8012
ORM1 7971
GAA 7968
COMMD9 7967
PSEN1 7961
COTL1 7933
PGLYRP1 7910
CMTM6 7891
CD53 7884
ACTR2 7870
KCMF1 7869
PECAM1 7855
PSMD6 7846
SIRPB1 7843
TRAPPC1 7806
RAB18 7801
PGRMC1 7795
PTPRJ 7783
LCN2 7755
DBNL 7749
GLIPR1 7739
DOCK2 7725
GUSB 7723
CANT1 7707
NCKAP1L 7673
LAMP1 7631
UNC13D 7607
ACTR10 7605
LAMTOR3 7574
ARSB 7572
LAMTOR2 7567
CRISP3 7552
TYROBP 7539
MAPK1 7493
ROCK1 7489
RNASE3 7471
FOLR3 7451
CFP 7445
MPO 7437
OSTF1 7426
NAPRT 7412
PSMD2 7411
FUCA1 7408
MANBA 7386
ITGAX 7337
VCL 7328
COPB1 7321
ELANE 7320
RAP1A 7305
GDI2 7282
AP2A2 7257
PSMD1 7241
TUBB4B 7240
LYZ 7213
TCIRG1 7188
LAIR1 7184
IGF2R 7149
PSAP 7145
GALNS 7102
RAB14 7095
NBEAL2 7086
SURF4 7058
MVP 7053
TSPAN14 6971
ATP8B4 6970
PAFAH1B2 6942
DYNC1LI1 6941
DDOST 6931
CYBA 6922
METTL7A 6920
ERP44 6905
CSTB 6904
VCP 6886
MAN2B1 6878
CXCR1 6864
CEACAM3 6838
PRTN3 6762
AP1M1 6711
STOM 6704
RAB5B 6690
YPEL5 6684
BPI 6666
CD58 6647
CNN2 6645
DDX3X 6614
IQGAP2 6599
PSMD12 6556
CCT8 6552
HSPA6 6514
AOC1 6509
HSPA1B 6470
ARMC8 6398
SNAP29 6390
CTSH 6360
TICAM2 6335
SRP14 6320
LTF 6306
GPI 6284
NFKB1 6277
ARHGAP9 6256
PSMD11 6231
GGH 6205
C6orf120 6192
TCN1 6182
DEGS1 6169
VPS35L 6118
ITGAV 6106
PTPN6 6096
NDUFC2 6093
ATP11B 6064
DEFA1 6061
DEFA4 6057
TNFRSF1B 6045
PPBP 6042
FABP5 6021
CHIT1 6012
PSMD7 5963
DYNLL1 5952
PSMD13 5948
RNASET2 5922
PDAP1 5908
CPNE3 5872
IST1 5862
CXCR2 5861
CD59 5859
SERPINB6 5854
PGM1 5843
CXCL1 5824
PTX3 5797
BIN2 5745
ADAM8 5634
A1BG 5559
FAF2 5554
STBD1 5544
AZU1 5507
NPC2 5458
XRCC5 5384
NRAS 5363
RAB24 5354
PSMA2 5339
TARM1 5307
DGAT1 5306
SLPI 5298
VAMP8 5218
PTPRN2 5183
ACLY 5159
CTSG 5115
SIGLEC14 5087
CEACAM8 4956
HVCN1 4912
PLAU 4903
FTH1 4902
STING1 4791
CAMP 4785
ABCA13 4768
PSMD3 4618
RAP2C 4599
KRT1 4537
CLEC12A 4535
CEACAM6 4509
DYNLT1 4450
FCGR3B 4313
B4GALT1 4292
GHDC 4158
GOLGA7 4055
CSNK2B 3969
SLC15A4 3724
STK11IP 3586
ARSA 3486
PSMB1 3374
SLCO4C1 3212
RAP1B 3206
RAB4B 3137
SLC44A2 2700
MAGT1 2613
PSMD14 2611
PSMC2 2598
OLR1 2486
CD177 2457
KPNB1 2430
MS4A3 2361
CTSC 2326
MLEC 2322
PTPRC 2240
CST3 2206
SLC2A5 2044
SVIP 2035
CFD 1984
PSMC3 1976
GSDMD 1955
SCAMP1 1868
HGSNAT 1867
NME2 1850
MMP9 1690
HSP90AA1 1326
NHLRC3 1276
HLA-C 1018
APEH 997
MME 916
NFASC 866
FGL2 675
HLA-B 649
RAB44 573
PYGB 492
TMEM179B 449
ADGRE3 408
TXNDC5 393
EEF2 306
GSTP1 135
FRK -24
KCNAB2 -101
PRDX4 -144
HMGB1 -252
PIGR -487
CHI3L1 -650
RAP2B -771
DIAPH1 -854
COMMD3 -1363
DSP -1812
LRRC7 -1966
ILF2 -1979
UBR4 -2086
CD300A -2133
ORM2 -2564
ADGRE5 -2571
HLA-A -2573
APRT -2766
AGL -3136
PFKL -3277
CPNE1 -3397
ALDOC -3438
SLC27A2 -3831
MIF -3863
HLA-H -3889
STK10 -3898
PA2G4 -3916
XRCC6 -4471
DPP7 -4586
SYNGR1 -4629
AGA -4632
EPX -4838
EEF1A1 -5087
JUP -5353
PSMA5 -6053
RAB9B -6552
CAND1 -6554
PPIA -6766
HSP90AB1 -6863
B2M -6920
PTGES2 -6926
DSC1 -6927
TUBB -6956
HRNR -7349
BST2 -7385
LPCAT1 -7428
PTPRB -7607
DYNC1H1 -7685
HUWE1 -7977
CDK13 -8392
CCT2 -8825
PPIE -9002
CRACR2A -9069
TMEM63A -9137
CEP290 -9182
ENPP4 -9583
IMPDH2 -9916
ORMDL3 -9997
ATAD3B -10079
ACTR1B -10514
TMC6 -10606
DSN1 -10773
ITGAL -10847
HSPA8 -10922
SPTAN1 -11426
FRMPD3 -11469
NIT2 -11695
RAB37 -11793
CLEC4C -11809
HMOX2 -11819
ATP8A1 -11842
TBC1D10C -11861
CD47 -12114
C3 -12262
RHOF -12344



GRB2:SOS provides linkage to MAPK signaling for Integrins

GRB2:SOS provides linkage to MAPK signaling for Integrins
435
set GRB2:SOS provides linkage to MAPK signaling for Integrins
setSize 12
pANOVA 0.000497
s.dist 0.58
p.adjustANOVA 0.00229



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 9304
ITGA2B 8893
APBB1IP 8744
TLN1 8525
ITGB3 8291
FN1 8284
RAP1A 7305
VWF 6641
PTK2 4462
RAP1B 3206
SOS1 -5700
SRC -8820

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 9304
ITGA2B 8893
APBB1IP 8744
TLN1 8525
ITGB3 8291
FN1 8284
RAP1A 7305
VWF 6641
PTK2 4462
RAP1B 3206
SOS1 -5700
SRC -8820



PD-1 signaling

PD-1 signaling
780
set PD-1 signaling
setSize 28
pANOVA 1.11e-07
s.dist -0.579
p.adjustANOVA 1.87e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD247 -12345
HLA-DPA1 -12316
HLA-DPB1 -12248
HLA-DRA -12009
TRBC1 -12006
HLA-DQA1 -11992
LCK -11838
CD3G -11526
TRAC -11482
CD3D -11401
CD3E -11302
TRBV12-3 -10436
TRAV19 -9915
TRAV29DV5 -9673
TRBV7-9 -9539
HLA-DQB2 -9401
HLA-DRB1 -8075
CD274 -7563
TRAV8-4 -7261
PDCD1 -6792

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD247 -12345
HLA-DPA1 -12316
HLA-DPB1 -12248
HLA-DRA -12009
TRBC1 -12006
HLA-DQA1 -11992
LCK -11838
CD3G -11526
TRAC -11482
CD3D -11401
CD3E -11302
TRBV12-3 -10436
TRAV19 -9915
TRAV29DV5 -9673
TRBV7-9 -9539
HLA-DQB2 -9401
HLA-DRB1 -8075
CD274 -7563
TRAV8-4 -7261
PDCD1 -6792
HLA-DQB1 -6416
CD4 -5406
HLA-DRB5 -4971
HLA-DQA2 -4806
PDCD1LG2 -3326
CSK 5219
PTPN11 5314
PTPN6 6096



Insulin receptor recycling

Insulin receptor recycling
541
set Insulin receptor recycling
setSize 21
pANOVA 6.43e-06
s.dist 0.569
p.adjustANOVA 5.7e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP6V0A1 9423
ATP6V1A 9302
ATP6V0D1 9245
ATP6V0C 9127
ATP6V1B2 9057
ATP6V1D 9047
ATP6V0B 8598
ATP6V0E1 8596
ATP6V1C1 8539
INSR 8282
ATP6AP1 8160
ATP6V1H 8064
ATP6V1E1 8035
TCIRG1 7188
ATP6V1F 5878
ATP6V1E2 5730
ATP6V1G1 3931
ATP6V1C2 -2219
ATP6V1G2 -9515
ATP6V0E2 -11555

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP6V0A1 9423
ATP6V1A 9302
ATP6V0D1 9245
ATP6V0C 9127
ATP6V1B2 9057
ATP6V1D 9047
ATP6V0B 8598
ATP6V0E1 8596
ATP6V1C1 8539
INSR 8282
ATP6AP1 8160
ATP6V1H 8064
ATP6V1E1 8035
TCIRG1 7188
ATP6V1F 5878
ATP6V1E2 5730
ATP6V1G1 3931
ATP6V1C2 -2219
ATP6V1G2 -9515
ATP6V0E2 -11555
ATP6V0A2 -12211



Dissolution of Fibrin Clot

Dissolution of Fibrin Clot
302
set Dissolution of Fibrin Clot
setSize 12
pANOVA 0.00067
s.dist 0.567
p.adjustANOVA 0.00293



Top enriched genes

Top 20 genes
GeneID Gene Rank
SERPINB2 9438
SERPINB8 9205
ANXA2 8544
PLAUR 8424
SERPINE1 7483
S100A10 6860
SERPINE2 6451
SERPINB6 5854
PLAU 4903
PLAT -1242
PLG -1977
SERPINF2 -6574

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SERPINB2 9438
SERPINB8 9205
ANXA2 8544
PLAUR 8424
SERPINE1 7483
S100A10 6860
SERPINE2 6451
SERPINB6 5854
PLAU 4903
PLAT -1242
PLG -1977
SERPINF2 -6574



Retrograde neurotrophin signalling

Retrograde neurotrophin signalling
1013
set Retrograde neurotrophin signalling
setSize 12
pANOVA 0.000674
s.dist 0.567
p.adjustANOVA 0.00293



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLTC 9000
AP2M1 8627
CLTA 8376
AP2S1 8026
AP2A2 7257
DNM3 7045
AP2A1 6832
DNM2 6089
DNM1 3587
DNAL4 3398
AP2B1 -2709
NTRK1 -8193

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLTC 9000
AP2M1 8627
CLTA 8376
AP2S1 8026
AP2A2 7257
DNM3 7045
AP2A1 6832
DNM2 6089
DNM1 3587
DNAL4 3398
AP2B1 -2709
NTRK1 -8193



Signaling by Leptin

Signaling by Leptin
1106
set Signaling by Leptin
setSize 10
pANOVA 0.00197
s.dist 0.565
p.adjustANOVA 0.00707



Top enriched genes

Top 20 genes
GeneID Gene Rank
SOCS3 9476
IRS2 8569
STAT3 8098
STAT5A 6965
STAT5B 6925
LEPR 6485
PTPN11 5314
JAK2 2691
IRS1 1741
SH2B1 -8670

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SOCS3 9476
IRS2 8569
STAT3 8098
STAT5A 6965
STAT5B 6925
LEPR 6485
PTPN11 5314
JAK2 2691
IRS1 1741
SH2B1 -8670



COPI-independent Golgi-to-ER retrograde traffic

COPI-independent Golgi-to-ER retrograde traffic
133
set COPI-independent Golgi-to-ER retrograde traffic
setSize 33
pANOVA 2.11e-08
s.dist 0.563
p.adjustANOVA 4.24e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
PLA2G4A 9180
DCTN2 9157
GALNT2 8843
BICD2 8746
CAPZA2 8597
DCTN4 8387
RAB6A 8148
CAPZA1 8135
CAPZB 8015
RAB18 7801
DYNC1I2 7735
ACTR10 7605
DCTN6 7300
ACTR1A 7002
PAFAH1B2 6942
DYNC1LI1 6941
GALNT1 6508
RAB6B 6053
DCTN3 5994
DYNLL1 5952

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLA2G4A 9180
DCTN2 9157
GALNT2 8843
BICD2 8746
CAPZA2 8597
DCTN4 8387
RAB6A 8148
CAPZA1 8135
CAPZB 8015
RAB18 7801
DYNC1I2 7735
ACTR10 7605
DCTN6 7300
ACTR1A 7002
PAFAH1B2 6942
DYNC1LI1 6941
GALNT1 6508
RAB6B 6053
DCTN3 5994
DYNLL1 5952
RAB3GAP1 5768
PAFAH1B1 5470
DCTN1 5078
AGPAT3 4809
RAB3GAP2 4429
PAFAH1B3 4417
DYNC1LI2 4273
DYNC1I1 4187
DYNLL2 -3980
DCTN5 -4086
BICD1 -7365
DYNC1H1 -7685
PLA2G6 -12122



Detoxification of Reactive Oxygen Species

Detoxification of Reactive Oxygen Species
279
set Detoxification of Reactive Oxygen Species
setSize 32
pANOVA 3.64e-08
s.dist 0.562
p.adjustANOVA 6.9e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRDX3 9366
GPX1 9314
NCF4 9268
GSR 9235
NCF2 9190
CAT 9123
CYBB 9031
ERO1A 8943
PRDX6 8937
PRDX5 8531
P4HB 8440
TXN 8285
TXNRD1 8192
TXNRD2 7526
NCF1 7334
PRDX1 7030
CYBA 6922
TXN2 4651
SOD2 4390
ATOX1 4338

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRDX3 9366
GPX1 9314
NCF4 9268
GSR 9235
NCF2 9190
CAT 9123
CYBB 9031
ERO1A 8943
PRDX6 8937
PRDX5 8531
P4HB 8440
TXN 8285
TXNRD1 8192
TXNRD2 7526
NCF1 7334
PRDX1 7030
CYBA 6922
TXN2 4651
SOD2 4390
ATOX1 4338
PRDX2 3428
NUDT2 2988
CCS 1538
NOX5 1175
NOX4 1114
ATP7A 694
GPX3 680
GSTP1 135
CYCS -1334
GPX2 -3533
SOD1 -4862
GPX7 -8901



RHO GTPases Activate NADPH Oxidases

RHO GTPases Activate NADPH Oxidases
888
set RHO GTPases Activate NADPH Oxidases
setSize 21
pANOVA 9.01e-06
s.dist 0.56
p.adjustANOVA 7.33e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A9 9516
S100A8 9503
NCF4 9268
NCF2 9190
MAPK14 9104
CYBB 9031
PRKCD 9008
MAPK3 8953
RAC1 8793
MAPK1 7493
NCF1 7334
PRKCB 7097
CYBA 6922
RAC2 5163
MAPK11 3826
PIK3C3 1619
PRKCA 1132
PIN1 -3188
PIK3R4 -4062
NOXA1 -5464

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A9 9516
S100A8 9503
NCF4 9268
NCF2 9190
MAPK14 9104
CYBB 9031
PRKCD 9008
MAPK3 8953
RAC1 8793
MAPK1 7493
NCF1 7334
PRKCB 7097
CYBA 6922
RAC2 5163
MAPK11 3826
PIK3C3 1619
PRKCA 1132
PIN1 -3188
PIK3R4 -4062
NOXA1 -5464
PRKCZ -11629



PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
802
set PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
setSize 13
pANOVA 0.000515
s.dist 0.556
p.adjustANOVA 0.00235



Top enriched genes

Top 20 genes
GeneID Gene Rank
CRK 8906
RAC1 8793
RHOA 8319
DOCK1 7314
ELMO1 6258
PXN 6230
PTK6 5956
NRAS 5363
ELMO2 4397
KRAS 3702
RASA1 2106
ARHGAP35 -3359
HRAS -3382

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRK 8906
RAC1 8793
RHOA 8319
DOCK1 7314
ELMO1 6258
PXN 6230
PTK6 5956
NRAS 5363
ELMO2 4397
KRAS 3702
RASA1 2106
ARHGAP35 -3359
HRAS -3382



Platelet sensitization by LDL

Platelet sensitization by LDL
834
set Platelet sensitization by LDL
setSize 16
pANOVA 0.000128
s.dist 0.553
p.adjustANOVA 0.000708



Top enriched genes

Top 20 genes
GeneID Gene Rank
PLA2G4A 9180
MAPK14 9104
FGR 8478
PPP2CA 8234
PECAM1 7855
PPP2CB 7712
PPP2R5B 6774
PTPN6 6096
PPP2R5A 5897
PTPN11 5314
PPP2R1A 4589
LRP8 4568
PPP2R5D 2421
PPP2R1B -241
PPP2R5E -680
PPP2R5C -11265

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLA2G4A 9180
MAPK14 9104
FGR 8478
PPP2CA 8234
PECAM1 7855
PPP2CB 7712
PPP2R5B 6774
PTPN6 6096
PPP2R5A 5897
PTPN11 5314
PPP2R1A 4589
LRP8 4568
PPP2R5D 2421
PPP2R1B -241
PPP2R5E -680
PPP2R5C -11265



Hyaluronan metabolism

Hyaluronan metabolism
505
set Hyaluronan metabolism
setSize 15
pANOVA 0.00022
s.dist 0.551
p.adjustANOVA 0.00113



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHP1 9258
HYAL2 9088
LYVE1 8999
HEXB 8776
CD44 8333
SLC9A1 7969
GUSB 7723
STAB2 5569
HYAL3 5229
HYAL1 4164
HMMR 3808
ABCC5 2477
HEXA 1261
HAS3 -6197
CEMIP -7418

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHP1 9258
HYAL2 9088
LYVE1 8999
HEXB 8776
CD44 8333
SLC9A1 7969
GUSB 7723
STAB2 5569
HYAL3 5229
HYAL1 4164
HMMR 3808
ABCC5 2477
HEXA 1261
HAS3 -6197
CEMIP -7418



Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization
469
set Golgi Cisternae Pericentriolar Stack Reorganization
setSize 14
pANOVA 0.000365
s.dist 0.55
p.adjustANOVA 0.00175



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAB1A 9052
MAPK3 8953
RAB2A 8604
RAB1B 8313
MAPK1 7493
GORASP1 6606
GOLGA2 6203
USO1 4154
CCNB2 3683
BLZF1 3281
PLK1 3002
CDK1 1540
CCNB1 467
GORASP2 -7034

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAB1A 9052
MAPK3 8953
RAB2A 8604
RAB1B 8313
MAPK1 7493
GORASP1 6606
GOLGA2 6203
USO1 4154
CCNB2 3683
BLZF1 3281
PLK1 3002
CDK1 1540
CCNB1 467
GORASP2 -7034



RHO GTPases Activate ROCKs

RHO GTPases Activate ROCKs
889
set RHO GTPases Activate ROCKs
setSize 18
pANOVA 6.85e-05
s.dist 0.542
p.adjustANOVA 0.00042



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYL6 8576
RHOA 8319
PAK1 8230
CFL1 8186
LIMK2 8074
MYL9 7703
ROCK1 7489
PPP1CB 7064
MYH9 6685
ROCK2 6138
PPP1R12A 6050
MYL12B 5088
LIMK1 4679
PPP1R12B 1775
RHOB 1254
MYH10 653
MYH11 -3522
RHOC -11360

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYL6 8576
RHOA 8319
PAK1 8230
CFL1 8186
LIMK2 8074
MYL9 7703
ROCK1 7489
PPP1CB 7064
MYH9 6685
ROCK2 6138
PPP1R12A 6050
MYL12B 5088
LIMK1 4679
PPP1R12B 1775
RHOB 1254
MYH10 653
MYH11 -3522
RHOC -11360



Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains
822
set Phosphorylation of CD3 and TCR zeta chains
setSize 27
pANOVA 1.38e-06
s.dist -0.537
p.adjustANOVA 1.62e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD247 -12345
HLA-DPA1 -12316
HLA-DPB1 -12248
HLA-DRA -12009
TRBC1 -12006
HLA-DQA1 -11992
LCK -11838
CD3G -11526
TRAC -11482
CD3D -11401
CD3E -11302
TRBV12-3 -10436
TRAV19 -9915
TRAV29DV5 -9673
TRBV7-9 -9539
HLA-DQB2 -9401
HLA-DRB1 -8075
TRAV8-4 -7261
HLA-DQB1 -6416
CD4 -5406

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD247 -12345
HLA-DPA1 -12316
HLA-DPB1 -12248
HLA-DRA -12009
TRBC1 -12006
HLA-DQA1 -11992
LCK -11838
CD3G -11526
TRAC -11482
CD3D -11401
CD3E -11302
TRBV12-3 -10436
TRAV19 -9915
TRAV29DV5 -9673
TRBV7-9 -9539
HLA-DQB2 -9401
HLA-DRB1 -8075
TRAV8-4 -7261
HLA-DQB1 -6416
CD4 -5406
HLA-DRB5 -4971
HLA-DQA2 -4806
PTPN22 -1208
PTPRC 2240
CSK 5219
PAG1 5268
PTPRJ 7783



Diseases associated with the TLR signaling cascade

Diseases associated with the TLR signaling cascade
289
set Diseases associated with the TLR signaling cascade
setSize 23
pANOVA 8.79e-06
s.dist 0.535
p.adjustANOVA 7.23e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD36 9444
TLR5 9201
TLR2 9103
CD14 9097
TLR4 9016
TLR1 8932
TLR6 8840
LY96 8795
MYD88 8136
CHUK 7966
BTK 7206
NFKBIA 6807
TICAM1 6307
NFKB1 6277
TIRAP 5640
IKBKG 5377
UNC93B1 4170
NFKB2 -1165
RELA -1803
TLR10 -2961

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD36 9444
TLR5 9201
TLR2 9103
CD14 9097
TLR4 9016
TLR1 8932
TLR6 8840
LY96 8795
MYD88 8136
CHUK 7966
BTK 7206
NFKBIA 6807
TICAM1 6307
NFKB1 6277
TIRAP 5640
IKBKG 5377
UNC93B1 4170
NFKB2 -1165
RELA -1803
TLR10 -2961
IKBKB -5386
TRAF3 -5576
TLR3 -11525



Diseases of Immune System

Diseases of Immune System
291
set Diseases of Immune System
setSize 23
pANOVA 8.79e-06
s.dist 0.535
p.adjustANOVA 7.23e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD36 9444
TLR5 9201
TLR2 9103
CD14 9097
TLR4 9016
TLR1 8932
TLR6 8840
LY96 8795
MYD88 8136
CHUK 7966
BTK 7206
NFKBIA 6807
TICAM1 6307
NFKB1 6277
TIRAP 5640
IKBKG 5377
UNC93B1 4170
NFKB2 -1165
RELA -1803
TLR10 -2961

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD36 9444
TLR5 9201
TLR2 9103
CD14 9097
TLR4 9016
TLR1 8932
TLR6 8840
LY96 8795
MYD88 8136
CHUK 7966
BTK 7206
NFKBIA 6807
TICAM1 6307
NFKB1 6277
TIRAP 5640
IKBKG 5377
UNC93B1 4170
NFKB2 -1165
RELA -1803
TLR10 -2961
IKBKB -5386
TRAF3 -5576
TLR3 -11525



IRAK1 recruits IKK complex

IRAK1 recruits IKK complex
510
set IRAK1 recruits IKK complex
setSize 10
pANOVA 0.00346
s.dist 0.534
p.adjustANOVA 0.0114



Top enriched genes

Top 20 genes
GeneID Gene Rank
PELI2 8314
CHUK 7966
PELI3 7716
PELI1 6715
IRAK1 6131
UBE2V1 5637
IKBKG 5377
UBE2N 1936
TRAF6 -229
IKBKB -5386

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PELI2 8314
CHUK 7966
PELI3 7716
PELI1 6715
IRAK1 6131
UBE2V1 5637
IKBKG 5377
UBE2N 1936
TRAF6 -229
IKBKB -5386



IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
511
set IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
setSize 10
pANOVA 0.00346
s.dist 0.534
p.adjustANOVA 0.0114



Top enriched genes

Top 20 genes
GeneID Gene Rank
PELI2 8314
CHUK 7966
PELI3 7716
PELI1 6715
IRAK1 6131
UBE2V1 5637
IKBKG 5377
UBE2N 1936
TRAF6 -229
IKBKB -5386

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PELI2 8314
CHUK 7966
PELI3 7716
PELI1 6715
IRAK1 6131
UBE2V1 5637
IKBKG 5377
UBE2N 1936
TRAF6 -229
IKBKB -5386



MET activates RAP1 and RAC1

MET activates RAP1 and RAC1
621
set MET activates RAP1 and RAC1
setSize 10
pANOVA 0.00366
s.dist 0.531
p.adjustANOVA 0.0119



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 9304
CRK 8906
HGF 8863
RAC1 8793
RAP1A 7305
GAB1 5679
CRKL 3966
RAP1B 3206
DOCK7 -2369
RAPGEF1 -9826

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 9304
CRK 8906
HGF 8863
RAC1 8793
RAP1A 7305
GAB1 5679
CRKL 3966
RAP1B 3206
DOCK7 -2369
RAPGEF1 -9826



NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus
708
set NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize 10
pANOVA 0.00385
s.dist 0.528
p.adjustANOVA 0.0123



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCSTN 9186
ADAM10 8791
JAG1 8743
PSEN1 7961
APH1B 6280
PSENEN 5735
YWHAZ 5624
APH1A 4133
NOTCH4 -5229
PSEN2 -7718

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCSTN 9186
ADAM10 8791
JAG1 8743
PSEN1 7961
APH1B 6280
PSENEN 5735
YWHAZ 5624
APH1A 4133
NOTCH4 -5229
PSEN2 -7718



Negative regulation of MET activity

Negative regulation of MET activity
724
set Negative regulation of MET activity
setSize 18
pANOVA 0.000111
s.dist 0.526
p.adjustANOVA 0.000639



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 9304
HGF 8863
PTPRJ 7783
SH3GL1 7625
PTPN2 7615
CBL 7480
UBB 6639
USP8 6418
SH3KBP1 6173
STAM2 6159
PTPN1 5722
HGS 4513
UBC 4439
EPS15 4138
STAM 1285
UBA52 1121
RPS27A -6938
LRIG1 -10389

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 9304
HGF 8863
PTPRJ 7783
SH3GL1 7625
PTPN2 7615
CBL 7480
UBB 6639
USP8 6418
SH3KBP1 6173
STAM2 6159
PTPN1 5722
HGS 4513
UBC 4439
EPS15 4138
STAM 1285
UBA52 1121
RPS27A -6938
LRIG1 -10389



Budding and maturation of HIV virion

Budding and maturation of HIV virion
117
set Budding and maturation of HIV virion
setSize 26
pANOVA 3.45e-06
s.dist 0.526
p.adjustANOVA 3.41e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHMP4B 8866
CHMP2A 8780
UBAP1 8701
CHMP3 8349
VPS37C 8010
NEDD4L 7875
TSG101 7786
MVB12A 7400
UBB 6639
PDCD6IP 6528
VPS37A 6467
VTA1 6185
CHMP2B 5714
CHMP6 5499
VPS4B 5212
MVB12B 5175
CHMP5 4943
UBC 4439
VPS28 4199
VPS37B 3908

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHMP4B 8866
CHMP2A 8780
UBAP1 8701
CHMP3 8349
VPS37C 8010
NEDD4L 7875
TSG101 7786
MVB12A 7400
UBB 6639
PDCD6IP 6528
VPS37A 6467
VTA1 6185
CHMP2B 5714
CHMP6 5499
VPS4B 5212
MVB12B 5175
CHMP5 4943
UBC 4439
VPS28 4199
VPS37B 3908
CHMP4A 2400
UBA52 1121
VPS4A 784
PPIA -6766
RPS27A -6938
CHMP7 -8802



InlB-mediated entry of Listeria monocytogenes into host cell

InlB-mediated entry of Listeria monocytogenes into host cell
536
set InlB-mediated entry of Listeria monocytogenes into host cell
setSize 12
pANOVA 0.00161
s.dist 0.526
p.adjustANOVA 0.00605



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 9304
SH3GL1 7625
CBL 7480
UBB 6639
SH3KBP1 6173
STAM2 6159
HGS 4513
UBC 4439
EPS15 4138
STAM 1285
UBA52 1121
RPS27A -6938

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 9304
SH3GL1 7625
CBL 7480
UBB 6639
SH3KBP1 6173
STAM2 6159
HGS 4513
UBC 4439
EPS15 4138
STAM 1285
UBA52 1121
RPS27A -6938



DNA strand elongation

DNA strand elongation
247
set DNA strand elongation
setSize 32
pANOVA 3.21e-07
s.dist -0.522
p.adjustANOVA 4.92e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM3 -12200
POLA1 -12150
MCM7 -12129
RPA1 -12004
RFC5 -11712
POLA2 -11575
LIG1 -11053
MCM8 -10944
RFC4 -10702
FEN1 -10593
GINS3 -10508
RFC3 -10489
POLD2 -10351
GINS4 -10236
PRIM1 -10191
MCM6 -9715
RPA3 -8911
MCM4 -8701
RFC1 -7437
MCM5 -7292

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM3 -12200
POLA1 -12150
MCM7 -12129
RPA1 -12004
RFC5 -11712
POLA2 -11575
LIG1 -11053
MCM8 -10944
RFC4 -10702
FEN1 -10593
GINS3 -10508
RFC3 -10489
POLD2 -10351
GINS4 -10236
PRIM1 -10191
MCM6 -9715
RPA3 -8911
MCM4 -8701
RFC1 -7437
MCM5 -7292
MCM2 -7223
RPA2 -6306
PCNA -5969
PRIM2 -5575
GINS2 -4815
GINS1 -4401
DNA2 -2858
CDC45 -2659
POLD1 204
RFC2 4948
POLD4 6336
POLD3 8885



Cargo concentration in the ER

Cargo concentration in the ER
147
set Cargo concentration in the ER
setSize 30
pANOVA 7.76e-07
s.dist 0.521
p.adjustANOVA 1.03e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
F5 9485
SERPINA1 9168
CTSZ 8975
TGFA 8889
SEC24D 8115
CNIH1 7779
SEC24A 7660
SEC23A 7335
STX5 7166
MCFD2 7099
LMAN2 7080
F8 7022
LMAN2L 6937
SAR1B 6479
PREB 6368
COL7A1 6304
TMED2 6052
AREG 5977
SEC22B 5873
CD59 5859

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
F5 9485
SERPINA1 9168
CTSZ 8975
TGFA 8889
SEC24D 8115
CNIH1 7779
SEC24A 7660
SEC23A 7335
STX5 7166
MCFD2 7099
LMAN2 7080
F8 7022
LMAN2L 6937
SAR1B 6479
PREB 6368
COL7A1 6304
TMED2 6052
AREG 5977
SEC22B 5873
CD59 5859
MIA2 5574
SEC24B 3608
CTSC 2326
CNIH2 654
TMED10 323
GOSR2 -1456
SEC24C -2569
MIA3 -6245
CNIH3 -9011
LMAN1 -10630



Endosomal Sorting Complex Required For Transport (ESCRT)

Endosomal Sorting Complex Required For Transport (ESCRT)
341
set Endosomal Sorting Complex Required For Transport (ESCRT)
setSize 29
pANOVA 1.25e-06
s.dist 0.52
p.adjustANOVA 1.49e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHMP4B 8866
CHMP2A 8780
UBAP1 8701
CHMP3 8349
VPS37C 8010
TSG101 7786
VPS25 7638
MVB12A 7400
UBB 6639
VPS37A 6467
VTA1 6185
STAM2 6159
SNF8 5973
CHMP2B 5714
CHMP6 5499
VPS4B 5212
MVB12B 5175
CHMP5 4943
HGS 4513
UBC 4439

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHMP4B 8866
CHMP2A 8780
UBAP1 8701
CHMP3 8349
VPS37C 8010
TSG101 7786
VPS25 7638
MVB12A 7400
UBB 6639
VPS37A 6467
VTA1 6185
STAM2 6159
SNF8 5973
CHMP2B 5714
CHMP6 5499
VPS4B 5212
MVB12B 5175
CHMP5 4943
HGS 4513
UBC 4439
VPS28 4199
VPS37B 3908
CHMP4A 2400
STAM 1285
UBA52 1121
VPS4A 784
VPS36 -6848
RPS27A -6938
CHMP7 -8802



DNA methylation

DNA methylation
246
set DNA methylation
setSize 20
pANOVA 6.16e-05
s.dist 0.517
p.adjustANOVA 0.000382



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AJ 9374.0
H2BC21 9283.0
H2BC12 9051.0
H3-3A 8661.0
H2BC5 8003.0
H2AC6 7934.0
H2BC11 7912.0
H2BC4 7389.0
H2BC17 7285.0
H3C15 6699.5
H2AZ1 6036.0
H2BC9 5394.0
H2BC15 5312.0
H2AC20 4972.0
DNMT3B 4294.0
UHRF1 170.0
H2AZ2 -1209.0
DNMT3A -3039.0
H2BU1 -6555.0
DNMT1 -12257.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AJ 9374.0
H2BC21 9283.0
H2BC12 9051.0
H3-3A 8661.0
H2BC5 8003.0
H2AC6 7934.0
H2BC11 7912.0
H2BC4 7389.0
H2BC17 7285.0
H3C15 6699.5
H2AZ1 6036.0
H2BC9 5394.0
H2BC15 5312.0
H2AC20 4972.0
DNMT3B 4294.0
UHRF1 170.0
H2AZ2 -1209.0
DNMT3A -3039.0
H2BU1 -6555.0
DNMT1 -12257.0



Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models

Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models
278
set Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models
setSize 21
pANOVA 4.1e-05
s.dist 0.517
p.adjustANOVA 0.000274



Top enriched genes

Top 20 genes
GeneID Gene Rank
LMNB1 9345
APP 9177
YWHAE 9045
FOXO3 8682
CDK5 8616
CAPN1 8563
CAST 8164
CAPNS1 7729
BCL2L11 7384
PRDX1 7030
GOLGA2 6203
CDC25C 4969
SOD2 4390
LMNA 3887
JUN 3722
PRDX2 3428
CDC25A 2911
CAPN2 1064
CDK5R1 -1089
CDC25B -12017

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LMNB1 9345
APP 9177
YWHAE 9045
FOXO3 8682
CDK5 8616
CAPN1 8563
CAST 8164
CAPNS1 7729
BCL2L11 7384
PRDX1 7030
GOLGA2 6203
CDC25C 4969
SOD2 4390
LMNA 3887
JUN 3722
PRDX2 3428
CDC25A 2911
CAPN2 1064
CDK5R1 -1089
CDC25B -12017
FASLG -12371



Neurodegenerative Diseases

Neurodegenerative Diseases
733
set Neurodegenerative Diseases
setSize 21
pANOVA 4.1e-05
s.dist 0.517
p.adjustANOVA 0.000274



Top enriched genes

Top 20 genes
GeneID Gene Rank
LMNB1 9345
APP 9177
YWHAE 9045
FOXO3 8682
CDK5 8616
CAPN1 8563
CAST 8164
CAPNS1 7729
BCL2L11 7384
PRDX1 7030
GOLGA2 6203
CDC25C 4969
SOD2 4390
LMNA 3887
JUN 3722
PRDX2 3428
CDC25A 2911
CAPN2 1064
CDK5R1 -1089
CDC25B -12017

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LMNB1 9345
APP 9177
YWHAE 9045
FOXO3 8682
CDK5 8616
CAPN1 8563
CAST 8164
CAPNS1 7729
BCL2L11 7384
PRDX1 7030
GOLGA2 6203
CDC25C 4969
SOD2 4390
LMNA 3887
JUN 3722
PRDX2 3428
CDC25A 2911
CAPN2 1064
CDK5R1 -1089
CDC25B -12017
FASLG -12371



MAP2K and MAPK activation

MAP2K and MAPK activation
612
set MAP2K and MAPK activation
setSize 34
pANOVA 1.81e-07
s.dist 0.517
p.adjustANOVA 2.91e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAP2K1 9063
MAPK3 8953
ITGA2B 8893
APBB1IP 8744
MARK3 8697
TLN1 8525
ARRB2 8490
ITGB3 8291
FN1 8284
IQGAP1 8152
RAF1 7879
LAMTOR3 7574
LAMTOR2 7567
MAPK1 7493
VCL 7328
RAP1A 7305
MAP2K2 6794
VWF 6641
YWHAB 6385
NRAS 5363

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAP2K1 9063
MAPK3 8953
ITGA2B 8893
APBB1IP 8744
MARK3 8697
TLN1 8525
ARRB2 8490
ITGB3 8291
FN1 8284
IQGAP1 8152
RAF1 7879
LAMTOR3 7574
LAMTOR2 7567
MAPK1 7493
VCL 7328
RAP1A 7305
MAP2K2 6794
VWF 6641
YWHAB 6385
NRAS 5363
CSK 5219
KSR1 4167
WDR83 3718
KRAS 3702
RAP1B 3206
ARAF 2644
ARRB1 1998
BRAF 1308
KSR2 -3361
HRAS -3382
CNKSR2 -4781
CNKSR1 -7089
SRC -8820
PEBP1 -11270



VLDLR internalisation and degradation

VLDLR internalisation and degradation
1312
set VLDLR internalisation and degradation
setSize 12
pANOVA 0.00216
s.dist 0.511
p.adjustANOVA 0.00759



Top enriched genes

Top 20 genes
GeneID Gene Rank
PCSK9 9208
CLTC 9000
AP2M1 8627
CLTA 8376
AP2S1 8026
NR1H2 7415
AP2A2 7257
AP2A1 6832
AP2B1 -2709
NR1H3 -3597
MYLIP -3991
VLDLR -4385

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PCSK9 9208
CLTC 9000
AP2M1 8627
CLTA 8376
AP2S1 8026
NR1H2 7415
AP2A2 7257
AP2A1 6832
AP2B1 -2709
NR1H3 -3597
MYLIP -3991
VLDLR -4385



Transferrin endocytosis and recycling

Transferrin endocytosis and recycling
1269
set Transferrin endocytosis and recycling
setSize 26
pANOVA 6.92e-06
s.dist 0.509
p.adjustANOVA 5.98e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP6V0A1 9423
ATP6V1A 9302
ATP6V0D1 9245
ATP6V0C 9127
ATP6V1B2 9057
ATP6V1D 9047
HFE 8777
ATP6V0B 8598
ATP6V0E1 8596
ATP6V1C1 8539
ATP6AP1 8160
ATP6V1H 8064
ATP6V1E1 8035
MCOLN1 7740
TCIRG1 7188
STEAP3 5996
ATP6V1F 5878
ATP6V1E2 5730
ATP6V1G1 3931
TFRC 1524

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP6V0A1 9423
ATP6V1A 9302
ATP6V0D1 9245
ATP6V0C 9127
ATP6V1B2 9057
ATP6V1D 9047
HFE 8777
ATP6V0B 8598
ATP6V0E1 8596
ATP6V1C1 8539
ATP6AP1 8160
ATP6V1H 8064
ATP6V1E1 8035
MCOLN1 7740
TCIRG1 7188
STEAP3 5996
ATP6V1F 5878
ATP6V1E2 5730
ATP6V1G1 3931
TFRC 1524
TF 1102
ATP6V1C2 -2219
ATP6V1G2 -9515
TFR2 -9789
ATP6V0E2 -11555
ATP6V0A2 -12211



EPHB-mediated forward signaling

EPHB-mediated forward signaling
326
set EPHB-mediated forward signaling
setSize 32
pANOVA 7.98e-07
s.dist 0.504
p.adjustANOVA 1.03e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITSN1 9289
ARPC1B 9259
ACTB 9011
ARPC1A 8894
RAC1 8793
ARPC5 8686
ACTG1 8562
RHOA 8319
ARPC3 8277
PAK1 8230
CFL1 8186
LIMK2 8074
ACTR2 7870
ACTR3 7818
LYN 7809
CDC42 7537
ARPC4 7516
ROCK1 7489
ARPC2 7390
ROCK2 6138

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITSN1 9289
ARPC1B 9259
ACTB 9011
ARPC1A 8894
RAC1 8793
ARPC5 8686
ACTG1 8562
RHOA 8319
ARPC3 8277
PAK1 8230
CFL1 8186
LIMK2 8074
ACTR2 7870
ACTR3 7818
LYN 7809
CDC42 7537
ARPC4 7516
ROCK1 7489
ARPC2 7390
ROCK2 6138
SDC2 5397
LIMK1 4679
PTK2 4462
RASA1 2106
TIAM1 651
WASL 299
HRAS -3382
KALRN -3692
SRC -8820
ARHGEF28 -10288
FYN -11675
YES1 -12142



Gap junction trafficking

Gap junction trafficking
438
set Gap junction trafficking
setSize 14
pANOVA 0.00116
s.dist 0.501
p.adjustANOVA 0.00458



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLTC 9000
CLTCL1 8965
AP2M1 8627
CLTA 8376
DAB2 8112
GJD3 7996
DNM2 6089
CLTB 6084
GJB6 4761
DNM1 3587
GJC2 1083
GJC1 518
GJA3 -4935
MYO6 -11410

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLTC 9000
CLTCL1 8965
AP2M1 8627
CLTA 8376
DAB2 8112
GJD3 7996
DNM2 6089
CLTB 6084
GJB6 4761
DNM1 3587
GJC2 1083
GJC1 518
GJA3 -4935
MYO6 -11410



Platelet Adhesion to exposed collagen

Platelet Adhesion to exposed collagen
828
set Platelet Adhesion to exposed collagen
setSize 13
pANOVA 0.00176
s.dist 0.501
p.adjustANOVA 0.00649



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITGA1 8729
FCER1G 8131
LYN 7809
GP9 7506
GP1BB 7470
GP6 6818
VWF 6641
GP1BA 6279
ITGA2 4168
GP5 1295
ITGB1 -94
ITGA10 -322
FYN -11675

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA1 8729
FCER1G 8131
LYN 7809
GP9 7506
GP1BB 7470
GP6 6818
VWF 6641
GP1BA 6279
ITGA2 4168
GP5 1295
ITGB1 -94
ITGA10 -322
FYN -11675



Signaling by high-kinase activity BRAF mutants

Signaling by high-kinase activity BRAF mutants
1144
set Signaling by high-kinase activity BRAF mutants
setSize 31
pANOVA 1.54e-06
s.dist 0.499
p.adjustANOVA 1.77e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAP2K1 9063
MAPK3 8953
ITGA2B 8893
APBB1IP 8744
MARK3 8697
TLN1 8525
ARRB2 8490
ITGB3 8291
FN1 8284
IQGAP1 8152
RAF1 7879
MAPK1 7493
VCL 7328
RAP1A 7305
MAP2K2 6794
VWF 6641
YWHAB 6385
NRAS 5363
CSK 5219
KSR1 4167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAP2K1 9063
MAPK3 8953
ITGA2B 8893
APBB1IP 8744
MARK3 8697
TLN1 8525
ARRB2 8490
ITGB3 8291
FN1 8284
IQGAP1 8152
RAF1 7879
MAPK1 7493
VCL 7328
RAP1A 7305
MAP2K2 6794
VWF 6641
YWHAB 6385
NRAS 5363
CSK 5219
KSR1 4167
KRAS 3702
RAP1B 3206
ARAF 2644
ARRB1 1998
BRAF 1308
KSR2 -3361
HRAS -3382
CNKSR2 -4781
CNKSR1 -7089
SRC -8820
PEBP1 -11270



Smooth Muscle Contraction

Smooth Muscle Contraction
1151
set Smooth Muscle Contraction
setSize 31
pANOVA 1.87e-06
s.dist 0.495
p.adjustANOVA 2.1e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
DYSF 9464
TPM4 9242
ITGA1 8729
MYL6 8576
ANXA2 8544
TLN1 8525
PAK1 8230
CALD1 8216
PAK2 8185
MYL6B 8178
TPM3 8051
TPM1 8041
ANXA1 7842
MYL9 7703
VCL 7328
ITGB5 6923
MYL12A 6899
MYLK 6618
PXN 6230
MYL12B 5088

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DYSF 9464
TPM4 9242
ITGA1 8729
MYL6 8576
ANXA2 8544
TLN1 8525
PAK1 8230
CALD1 8216
PAK2 8185
MYL6B 8178
TPM3 8051
TPM1 8041
ANXA1 7842
MYL9 7703
VCL 7328
ITGB5 6923
MYL12A 6899
MYLK 6618
PXN 6230
MYL12B 5088
MYL5 3273
TRIM72 1879
SORBS1 1475
ANXA6 327
ACTA2 -429
CALM1 -2081
MYH11 -3522
GUCY1B2 -5054
MYLPF -8871
TPM2 -9185
SORBS3 -10978



Pentose phosphate pathway

Pentose phosphate pathway
808
set Pentose phosphate pathway
setSize 13
pANOVA 0.00226
s.dist 0.489
p.adjustANOVA 0.00794



Top enriched genes

Top 20 genes
GeneID Gene Rank
PGD 9481
TALDO1 9456
PGM2 9344
TKT 9342
G6PD 9004
DERA 8500
PGLS 6079
PRPS2 3562
RPE 2589
RPIA 1441
SHPK -2528
RBKS -3142
PRPS1 -12077

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PGD 9481
TALDO1 9456
PGM2 9344
TKT 9342
G6PD 9004
DERA 8500
PGLS 6079
PRPS2 3562
RPE 2589
RPIA 1441
SHPK -2528
RBKS -3142
PRPS1 -12077



RHO GTPases activate PAKs

RHO GTPases activate PAKs
894
set RHO GTPases activate PAKs
setSize 20
pANOVA 0.00017
s.dist 0.486
p.adjustANOVA 0.000902



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAC1 8793
MYL6 8576
PAK1 8230
PAK2 8185
MYL9 7703
CDC42 7537
PPP1CB 7064
MYH9 6685
MYLK 6618
PPP1R12A 6050
CTTN 5930
MYL12B 5088
LIMK1 4679
PPP1R12B 1775
MYH10 653
FLNA 483
CALM1 -2081
MYH11 -3522
PAK3 -4184
NF2 -6540

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAC1 8793
MYL6 8576
PAK1 8230
PAK2 8185
MYL9 7703
CDC42 7537
PPP1CB 7064
MYH9 6685
MYLK 6618
PPP1R12A 6050
CTTN 5930
MYL12B 5088
LIMK1 4679
PPP1R12B 1775
MYH10 653
FLNA 483
CALM1 -2081
MYH11 -3522
PAK3 -4184
NF2 -6540



RHO GTPases activate PKNs

RHO GTPases activate PKNs
895
set RHO GTPases activate PKNs
setSize 48
pANOVA 6.95e-09
s.dist 0.483
p.adjustANOVA 1.56e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AJ 9374.0
H2BC21 9283.0
YWHAG 9264.0
H2BC12 9051.0
YWHAE 9045.0
RAC1 8793.0
H3-3A 8661.0
YWHAH 8649.0
MYL6 8576.0
RHOA 8319.0
PAK1 8230.0
H2BC5 8003.0
H2AC6 7934.0
H2BC11 7912.0
MYL9 7703.0
H2BC4 7389.0
H2BC17 7285.0
PPP1CB 7064.0
PPP1R14A 6839.0
H3C15 6699.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AJ 9374.0
H2BC21 9283.0
YWHAG 9264.0
H2BC12 9051.0
YWHAE 9045.0
RAC1 8793.0
H3-3A 8661.0
YWHAH 8649.0
MYL6 8576.0
RHOA 8319.0
PAK1 8230.0
H2BC5 8003.0
H2AC6 7934.0
H2BC11 7912.0
MYL9 7703.0
H2BC4 7389.0
H2BC17 7285.0
PPP1CB 7064.0
PPP1R14A 6839.0
H3C15 6699.5
MYH9 6685.0
YWHAB 6385.0
PDPK1 6136.0
PPP1R12A 6050.0
H2AZ1 6036.0
YWHAZ 5624.0
H2BC9 5394.0
H2BC15 5312.0
MYL12B 5088.0
H2AC20 4972.0
CDC25C 4969.0
AR 4840.0
KLK2 3029.0
PPP1R12B 1775.0
SFN 1615.0
RHOB 1254.0
NCOA2 1092.0
MYH10 653.0
PKN2 98.0
H2AZ2 -1209.0
PKN1 -2208.0
MYH11 -3522.0
PKN3 -3793.0
H2BU1 -6555.0
YWHAQ -7340.0
KDM1A -9430.0
KDM4C -10749.0
RHOC -11360.0



Amyloid fiber formation

Amyloid fiber formation
70
set Amyloid fiber formation
setSize 51
pANOVA 2.44e-09
s.dist 0.483
p.adjustANOVA 5.64e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
SNCA 9354.0
H2BC21 9283.0
NCSTN 9186.0
APP 9177.0
FURIN 9075.0
H2BC12 9051.0
ADAM10 8791.0
GSN 8749.0
H3-3A 8661.0
SIAH2 8578.0
TGFBI 8211.0
H2BC5 8003.0
H2AC6 7934.0
H2BC11 7912.0
H2BC4 7389.0
H2BC17 7285.0
LYZ 7213.0
TSPAN14 6971.0
H3C15 6699.5
UBB 6639.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SNCA 9354.0
H2BC21 9283.0
NCSTN 9186.0
APP 9177.0
FURIN 9075.0
H2BC12 9051.0
ADAM10 8791.0
GSN 8749.0
H3-3A 8661.0
SIAH2 8578.0
TGFBI 8211.0
H2BC5 8003.0
H2AC6 7934.0
H2BC11 7912.0
H2BC4 7389.0
H2BC17 7285.0
LYZ 7213.0
TSPAN14 6971.0
H3C15 6699.5
UBB 6639.0
SORL1 6530.0
LTF 6306.0
APH1B 6280.0
TSPAN33 6170.0
H2AZ1 6036.0
ITM2B 5982.0
PSENEN 5735.0
USP9X 5464.0
H2BC9 5394.0
H2BC15 5312.0
H2AC20 4972.0
UBC 4439.0
APH1A 4133.0
GGA3 3816.0
BACE1 3609.0
MFGE8 3534.0
GGA1 2310.0
CST3 2206.0
UBA52 1121.0
TSPAN5 1028.0
NPPA -584.0
TSPAN15 -1876.0
CALB1 -2832.0
SIAH1 -3000.0
NAT8B -3939.0
H2BU1 -6555.0
GGA2 -6587.0
B2M -6920.0
RPS27A -6938.0
HSPG2 -7779.0
UBE2L6 -11293.0



Activation of the pre-replicative complex

Activation of the pre-replicative complex
51
set Activation of the pre-replicative complex
setSize 32
pANOVA 2.43e-06
s.dist -0.481
p.adjustANOVA 2.63e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM3 -12200
POLA1 -12150
MCM7 -12129
RPA1 -12004
POLE3 -11581
POLA2 -11575
MCM8 -10944
DBF4 -10925
ORC3 -10713
PRIM1 -10191
POLE2 -9941
ORC2 -9922
MCM6 -9715
ORC5 -9479
RPA3 -8911
MCM4 -8701
CDC7 -7855
POLE -7579
MCM5 -7292
MCM2 -7223

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM3 -12200
POLA1 -12150
MCM7 -12129
RPA1 -12004
POLE3 -11581
POLA2 -11575
MCM8 -10944
DBF4 -10925
ORC3 -10713
PRIM1 -10191
POLE2 -9941
ORC2 -9922
MCM6 -9715
ORC5 -9479
RPA3 -8911
MCM4 -8701
CDC7 -7855
POLE -7579
MCM5 -7292
MCM2 -7223
RPA2 -6306
PRIM2 -5575
CDK2 -5006
CDC45 -2659
ORC1 -2520
ORC4 -2028
CDT1 -287
MCM10 776
ORC6 1184
GMNN 1422
CDC6 2370
POLE4 5518



SHC1 events in EGFR signaling

SHC1 events in EGFR signaling
1033
set SHC1 events in EGFR signaling
setSize 12
pANOVA 0.00392
s.dist 0.481
p.adjustANOVA 0.0125



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 9304
TGFA 8889
EGF 8179
AREG 5977
NRAS 5363
HBEGF 5013
SHC1 4161
KRAS 3702
EPGN 2662
EREG 1888
HRAS -3382
SOS1 -5700

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 9304
TGFA 8889
EGF 8179
AREG 5977
NRAS 5363
HBEGF 5013
SHC1 4161
KRAS 3702
EPGN 2662
EREG 1888
HRAS -3382
SOS1 -5700



Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)

Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
266
set Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
setSize 12
pANOVA 0.00412
s.dist 0.478
p.adjustANOVA 0.013



Top enriched genes

Top 20 genes
GeneID Gene Rank
F12 9492
TPST1 9251
GP9 7506
GP1BB 7470
F8 7022
VWF 6641
GP1BA 6279
TPST2 5725
GGCX 5237
GP5 1295
KLKB1 -9019
SERPING1 -11197

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
F12 9492
TPST1 9251
GP9 7506
GP1BB 7470
F8 7022
VWF 6641
GP1BA 6279
TPST2 5725
GGCX 5237
GP5 1295
KLKB1 -9019
SERPING1 -11197



Diseases of hemostasis

Diseases of hemostasis
294
set Diseases of hemostasis
setSize 12
pANOVA 0.00412
s.dist 0.478
p.adjustANOVA 0.013



Top enriched genes

Top 20 genes
GeneID Gene Rank
F12 9492
TPST1 9251
GP9 7506
GP1BB 7470
F8 7022
VWF 6641
GP1BA 6279
TPST2 5725
GGCX 5237
GP5 1295
KLKB1 -9019
SERPING1 -11197

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
F12 9492
TPST1 9251
GP9 7506
GP1BB 7470
F8 7022
VWF 6641
GP1BA 6279
TPST2 5725
GGCX 5237
GP5 1295
KLKB1 -9019
SERPING1 -11197



GRB2 events in EGFR signaling

GRB2 events in EGFR signaling
433
set GRB2 events in EGFR signaling
setSize 11
pANOVA 0.00602
s.dist 0.478
p.adjustANOVA 0.0177



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 9304
TGFA 8889
EGF 8179
AREG 5977
NRAS 5363
HBEGF 5013
KRAS 3702
EPGN 2662
EREG 1888
HRAS -3382
SOS1 -5700

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 9304
TGFA 8889
EGF 8179
AREG 5977
NRAS 5363
HBEGF 5013
KRAS 3702
EPGN 2662
EREG 1888
HRAS -3382
SOS1 -5700



Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
347
set Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
setSize 11
pANOVA 0.00619
s.dist 0.477
p.adjustANOVA 0.0181



Top enriched genes

Top 20 genes
GeneID Gene Rank
PIK3CB 9038
IRS2 8569
LYN 7809
EPOR 7223
PIK3CD 6046
GAB1 5679
PIK3CA 4629
JAK2 2691
PIK3CG 1833
PIK3R5 -2304
PIK3R1 -9505

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIK3CB 9038
IRS2 8569
LYN 7809
EPOR 7223
PIK3CD 6046
GAB1 5679
PIK3CA 4629
JAK2 2691
PIK3CG 1833
PIK3R5 -2304
PIK3R1 -9505



Platelet Aggregation (Plug Formation)

Platelet Aggregation (Plug Formation)
829
set Platelet Aggregation (Plug Formation)
setSize 28
pANOVA 1.27e-05
s.dist 0.477
p.adjustANOVA 1e-04



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 9304
SYK 9076
CRK 8906
ITGA2B 8893
APBB1IP 8744
TLN1 8525
ITGB3 8291
FN1 8284
GP9 7506
GP1BB 7470
RAP1A 7305
VWF 6641
GP1BA 6279
PDPK1 6136
PTPN1 5722
CSK 5219
PTK2 4462
SHC1 4161
AKT1 3614
RAP1B 3206

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 9304
SYK 9076
CRK 8906
ITGA2B 8893
APBB1IP 8744
TLN1 8525
ITGB3 8291
FN1 8284
GP9 7506
GP1BB 7470
RAP1A 7305
VWF 6641
GP1BA 6279
PDPK1 6136
PTPN1 5722
CSK 5219
PTK2 4462
SHC1 4161
AKT1 3614
RAP1B 3206
MPL 2634
ADRA2A 2271
GP5 1295
RAPGEF3 -2911
SOS1 -5700
RASGRP2 -8529
SRC -8820
RASGRP1 -11974



Spry regulation of FGF signaling

Spry regulation of FGF signaling
1154
set Spry regulation of FGF signaling
setSize 16
pANOVA 0.000996
s.dist 0.475
p.adjustANOVA 0.00405



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 9304
MAPK3 8953
PPP2CA 8234
MKNK1 8170
PPP2CB 7712
MAPK1 7493
CBL 7480
UBB 6639
PTPN11 5314
PPP2R1A 4589
UBC 4439
BRAF 1308
UBA52 1121
SPRY2 -4603
RPS27A -6938
SRC -8820

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 9304
MAPK3 8953
PPP2CA 8234
MKNK1 8170
PPP2CB 7712
MAPK1 7493
CBL 7480
UBB 6639
PTPN11 5314
PPP2R1A 4589
UBC 4439
BRAF 1308
UBA52 1121
SPRY2 -4603
RPS27A -6938
SRC -8820



Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
32
set Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
setSize 22
pANOVA 0.000129
s.dist 0.472
p.adjustANOVA 0.000708



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AJ 9374.0
H2BC21 9283.0
H2BC12 9051.0
H3-3A 8661.0
H2BC5 8003.0
H2AC6 7934.0
H2BC11 7912.0
H2BC4 7389.0
H2BC17 7285.0
H3C15 6699.5
H2AZ1 6036.0
H2BC9 5394.0
H2BC15 5312.0
H2AC20 4972.0
AR 4840.0
KLK2 3029.0
NCOA2 1092.0
H2AZ2 -1209.0
PKN1 -2208.0
H2BU1 -6555.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AJ 9374.0
H2BC21 9283.0
H2BC12 9051.0
H3-3A 8661.0
H2BC5 8003.0
H2AC6 7934.0
H2BC11 7912.0
H2BC4 7389.0
H2BC17 7285.0
H3C15 6699.5
H2AZ1 6036.0
H2BC9 5394.0
H2BC15 5312.0
H2AC20 4972.0
AR 4840.0
KLK2 3029.0
NCOA2 1092.0
H2AZ2 -1209.0
PKN1 -2208.0
H2BU1 -6555.0
KDM1A -9430.0
KDM4C -10749.0



Signaling by RAF1 mutants

Signaling by RAF1 mutants
1130
set Signaling by RAF1 mutants
setSize 34
pANOVA 1.94e-06
s.dist 0.472
p.adjustANOVA 2.16e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAP2K1 9063
MAPK3 8953
ITGA2B 8893
APBB1IP 8744
MARK3 8697
TLN1 8525
ARRB2 8490
ITGB3 8291
FN1 8284
IQGAP1 8152
RAF1 7879
MAPK1 7493
VCL 7328
RAP1A 7305
MAP2K2 6794
VWF 6641
YWHAB 6385
NRAS 5363
CSK 5219
KSR1 4167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAP2K1 9063
MAPK3 8953
ITGA2B 8893
APBB1IP 8744
MARK3 8697
TLN1 8525
ARRB2 8490
ITGB3 8291
FN1 8284
IQGAP1 8152
RAF1 7879
MAPK1 7493
VCL 7328
RAP1A 7305
MAP2K2 6794
VWF 6641
YWHAB 6385
NRAS 5363
CSK 5219
KSR1 4167
KRAS 3702
RAP1B 3206
JAK2 2691
ARAF 2644
ARRB1 1998
CAMK2G 1921
BRAF 1308
CALM1 -2081
KSR2 -3361
HRAS -3382
CNKSR2 -4781
CNKSR1 -7089
SRC -8820
CAMK2D -11816



Josephin domain DUBs

Josephin domain DUBs
584
set Josephin domain DUBs
setSize 10
pANOVA 0.00989
s.dist 0.471
p.adjustANOVA 0.0261



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAD23B 8886
JOSD2 7931
VCP 6886
UBB 6639
RAD23A 6512
UBC 4439
ATXN3 1601
UBA52 1121
JOSD1 227
RPS27A -6938

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD23B 8886
JOSD2 7931
VCP 6886
UBB 6639
RAD23A 6512
UBC 4439
ATXN3 1601
UBA52 1121
JOSD1 227
RPS27A -6938



GAB1 signalosome

GAB1 signalosome
424
set GAB1 signalosome
setSize 15
pANOVA 0.00159
s.dist 0.471
p.adjustANOVA 0.00597



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 9304
TGFA 8889
EGF 8179
PXN 6230
AREG 5977
GAB1 5679
PTPN11 5314
PAG1 5268
CSK 5219
HBEGF 5013
PIK3CA 4629
EPGN 2662
EREG 1888
SRC -8820
PIK3R1 -9505

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 9304
TGFA 8889
EGF 8179
PXN 6230
AREG 5977
GAB1 5679
PTPN11 5314
PAG1 5268
CSK 5219
HBEGF 5013
PIK3CA 4629
EPGN 2662
EREG 1888
SRC -8820
PIK3R1 -9505



Trafficking of GluR2-containing AMPA receptors

Trafficking of GluR2-containing AMPA receptors
1250
set Trafficking of GluR2-containing AMPA receptors
setSize 12
pANOVA 0.00479
s.dist 0.47
p.adjustANOVA 0.0148



Top enriched genes

Top 20 genes
GeneID Gene Rank
NSF 8829
AP2M1 8627
AP2S1 8026
AP2A2 7257
PRKCB 7097
AP2A1 6832
TSPAN7 6469
PICK1 3594
PRKCA 1132
GRIA4 -97
AP2B1 -2709
GRIP1 -10411

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NSF 8829
AP2M1 8627
AP2S1 8026
AP2A2 7257
PRKCB 7097
AP2A1 6832
TSPAN7 6469
PICK1 3594
PRKCA 1132
GRIA4 -97
AP2B1 -2709
GRIP1 -10411



Generation of second messenger molecules

Generation of second messenger molecules
446
set Generation of second messenger molecules
setSize 38
pANOVA 7.2e-07
s.dist -0.464
p.adjustANOVA 9.74e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD247 -12345
HLA-DPA1 -12316
HLA-DPB1 -12248
EVL -12207
HLA-DRA -12009
TRBC1 -12006
HLA-DQA1 -11992
ZAP70 -11949
LCK -11838
LAT -11694
CD3G -11526
TRAC -11482
NCK1 -11454
CD3D -11401
CD3E -11302
ITK -11223
PLCG1 -11120
TRBV12-3 -10436
TRAV19 -9915
TRAV29DV5 -9673

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD247 -12345
HLA-DPA1 -12316
HLA-DPB1 -12248
EVL -12207
HLA-DRA -12009
TRBC1 -12006
HLA-DQA1 -11992
ZAP70 -11949
LCK -11838
LAT -11694
CD3G -11526
TRAC -11482
NCK1 -11454
CD3D -11401
CD3E -11302
ITK -11223
PLCG1 -11120
TRBV12-3 -10436
TRAV19 -9915
TRAV29DV5 -9673
TRBV7-9 -9539
HLA-DQB2 -9401
HLA-DRB1 -8075
TRAV8-4 -7261
HLA-DQB1 -6416
CD4 -5406
HLA-DRB5 -4971
HLA-DQA2 -4806
PAK3 -4184
ENAH -2707
LCP2 -1156
CD101 4146
GRAP2 4690
PLCG2 5006
VASP 8027
PAK2 8185
PAK1 8230
WAS 8560



EGFR downregulation

EGFR downregulation
320
set EGFR downregulation
setSize 27
pANOVA 3.34e-05
s.dist 0.461
p.adjustANOVA 0.000228



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 9304
TGFA 8889
EGF 8179
PTPN12 8151
EPN1 8045
SH3GL1 7625
CDC42 7537
CBL 7480
UBB 6639
SH3KBP1 6173
STAM2 6159
AREG 5977
HBEGF 5013
HGS 4513
UBC 4439
EPS15 4138
EPS15L1 3655
EPGN 2662
SPRY1 2302
EREG 1888

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 9304
TGFA 8889
EGF 8179
PTPN12 8151
EPN1 8045
SH3GL1 7625
CDC42 7537
CBL 7480
UBB 6639
SH3KBP1 6173
STAM2 6159
AREG 5977
HBEGF 5013
HGS 4513
UBC 4439
EPS15 4138
EPS15L1 3655
EPGN 2662
SPRY1 2302
EREG 1888
STAM 1285
UBA52 1121
PTPN3 -85
ARHGEF7 -4583
SPRY2 -4603
RPS27A -6938
PTPRK -7262



Response of Mtb to phagocytosis

Response of Mtb to phagocytosis
1010
set Response of Mtb to phagocytosis
setSize 22
pANOVA 0.000191
s.dist 0.459
p.adjustANOVA 0.00099



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAPK3 8953
ENO1 8890
RAB7A 8742
PGK1 8672
TRIM27 8142
ATP6V1H 8064
GSK3A 7760
MAPK1 7493
RAB5A 7103
UBB 6639
CORO1A 5178
CTSG 5115
HGS 4513
UBC 4439
KPNB1 2430
SFPQ 2253
KPNA1 1296
UBA52 1121
VPS33B -2091
DUSP16 -6655

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK3 8953
ENO1 8890
RAB7A 8742
PGK1 8672
TRIM27 8142
ATP6V1H 8064
GSK3A 7760
MAPK1 7493
RAB5A 7103
UBB 6639
CORO1A 5178
CTSG 5115
HGS 4513
UBC 4439
KPNB1 2430
SFPQ 2253
KPNA1 1296
UBA52 1121
VPS33B -2091
DUSP16 -6655
RPS27A -6938
RNF213 -11905



Antimicrobial peptides

Antimicrobial peptides
77
set Antimicrobial peptides
setSize 33
pANOVA 4.93e-06
s.dist 0.459
p.adjustANOVA 4.52e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A9 9516
S100A8 9503
CCR2 9449
CLU 9371
SLC11A1 9169
TLR2 9103
TLR1 8932
PGLYRP1 7910
LCN2 7755
RNASE3 7471
ELANE 7320
LYZ 7213
RNASE6 6837
PRTN3 6762
BPI 6666
LTF 6306
DEFA1 6061
DEFA4 6057
DEFA3 5385
CTSG 5115

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A9 9516
S100A8 9503
CCR2 9449
CLU 9371
SLC11A1 9169
TLR2 9103
TLR1 8932
PGLYRP1 7910
LCN2 7755
RNASE3 7471
ELANE 7320
LYZ 7213
RNASE6 6837
PRTN3 6762
BPI 6666
LTF 6306
DEFA1 6061
DEFA4 6057
DEFA3 5385
CTSG 5115
CAMP 4785
ATOX1 4338
PI3 3023
EPPIN 2251
ATP7A 694
PGLYRP2 -2281
HTN1 -3453
LEAP2 -4703
CD4 -5406
PDZD11 -6288
ITLN1 -6873
CCR6 -7862
GNLY -11428



The NLRP3 inflammasome

The NLRP3 inflammasome
1228
set The NLRP3 inflammasome
setSize 15
pANOVA 0.00213
s.dist 0.458
p.adjustANOVA 0.00751



Top enriched genes

Top 20 genes
GeneID Gene Rank
APP 9177
NLRP3 8901
PYCARD 8638
MEFV 8605
TXN 8285
PSTPIP1 7841
NFKB1 6277
PANX1 6267
CASP1 4224
P2RX7 3475
SUGT1 1544
NFKB2 -1165
RELA -1803
HSP90AB1 -6863
TXNIP -9600

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APP 9177
NLRP3 8901
PYCARD 8638
MEFV 8605
TXN 8285
PSTPIP1 7841
NFKB1 6277
PANX1 6267
CASP1 4224
P2RX7 3475
SUGT1 1544
NFKB2 -1165
RELA -1803
HSP90AB1 -6863
TXNIP -9600



Integrin signaling

Integrin signaling
545
set Integrin signaling
setSize 22
pANOVA 0.000208
s.dist 0.457
p.adjustANOVA 0.00108



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 9304
SYK 9076
CRK 8906
ITGA2B 8893
APBB1IP 8744
TLN1 8525
ITGB3 8291
FN1 8284
RAP1A 7305
VWF 6641
PDPK1 6136
PTPN1 5722
CSK 5219
PTK2 4462
SHC1 4161
AKT1 3614
RAP1B 3206
RAPGEF3 -2911
SOS1 -5700
RASGRP2 -8529

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 9304
SYK 9076
CRK 8906
ITGA2B 8893
APBB1IP 8744
TLN1 8525
ITGB3 8291
FN1 8284
RAP1A 7305
VWF 6641
PDPK1 6136
PTPN1 5722
CSK 5219
PTK2 4462
SHC1 4161
AKT1 3614
RAP1B 3206
RAPGEF3 -2911
SOS1 -5700
RASGRP2 -8529
SRC -8820
RASGRP1 -11974



Response to elevated platelet cytosolic Ca2+

Response to elevated platelet cytosolic Ca2+
1011
set Response to elevated platelet cytosolic Ca2+
setSize 110
pANOVA 1.25e-16
s.dist 0.457
p.adjustANOVA 1.22e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
F5 9485
CYB5R1 9460
CD36 9444
CLU 9371
APLP2 9347
QSOX1 9298
CD63 9287
ALDOA 9249
LHFPL2 9224
FERMT3 9223
APP 9177
SERPINA1 9168
ACTN1 9094
STXBP2 9035
ITGA2B 8893
F13A1 8876
HGF 8863
TOR4A 8861
VTI1B 8850
LAMP2 8786

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
F5 9485
CYB5R1 9460
CD36 9444
CLU 9371
APLP2 9347
QSOX1 9298
CD63 9287
ALDOA 9249
LHFPL2 9224
FERMT3 9223
APP 9177
SERPINA1 9168
ACTN1 9094
STXBP2 9035
ITGA2B 8893
F13A1 8876
HGF 8863
TOR4A 8861
VTI1B 8850
LAMP2 8786
SRGN 8761
TIMP1 8677
TLN1 8525
CLEC3B 8480
SELP 8457
ITGB3 8291
FN1 8284
SYTL4 8256
ANXA5 8210
CFL1 8186
EGF 8179
CAP1 8111
GAS6 8063
LY6G6F 8023
ORM1 7971
CALU 7894
PECAM1 7855
SCCPDH 7787
PROS1 7758
MMRN1 7714
SERPINE1 7483
VEGFA 7467
ABCC4 7434
STXBP3 7424
TAGLN2 7367
SPARC 7339
VCL 7328
PSAP 7145
PRKCB 7097
HSPA5 7029
F8 7022
WDR1 6976
VEGFC 6906
VWF 6641
TUBA4A 6484
GTPBP2 6331
TMSB4X 6295
PPBP 6042
THBS1 5951
CD9 5940
PF4 5707
A1BG 5559
PFN1 5459
PHACTR2 5410
PDGFA 5293
ECM1 5176
TGFB1 5153
ACTN4 5049
OLA1 4914
CD109 4316
ALB 3668
RAB27B 3386
ENDOD1 3361
TIMP3 3296
CHID1 2811
MANF 2550
PLEK 1999
CFD 1984
APOOL 1609
TTN 1195
PRKCA 1132
TF 1102
STX4 606
FLNA 483
TMX3 -775
PLG -1977
PCYOX1L -2009
CALM1 -2081
ORM2 -2564
MAGED2 -2687
ITIH3 -3017
SOD1 -4862
ITIH4 -6208
SERPINF2 -6574
BRPF3 -6615
PPIA -6766
TGFB2 -7492
SELENOP -7771
NHLRC2 -7835
TGFB3 -7891
VEGFB -7929
TEX264 -8366
CDC37L1 -8470
PDGFB -8577
A2M -9870
FAM3C -10062
HABP4 -10921
CTSW -11117
SERPING1 -11197
LGALS3BP -11459



activated TAK1 mediates p38 MAPK activation

activated TAK1 mediates p38 MAPK activation
1332
set activated TAK1 mediates p38 MAPK activation
setSize 19
pANOVA 0.000578
s.dist 0.456
p.adjustANOVA 0.0026



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAPK14 9104
MAP2K6 8887
MAP2K3 8748
NOD2 8442
MAPKAPK3 8382
TAB2 6964
IRAK1 6131
TAB1 5681
UBE2V1 5637
IKBKG 5377
MAPKAPK2 4054
MAPK11 3826
TAB3 3160
MAP3K7 2395
UBE2N 1936
RIPK2 1025
TRAF6 -229
IRAK2 -9548
NOD1 -12263

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK14 9104
MAP2K6 8887
MAP2K3 8748
NOD2 8442
MAPKAPK3 8382
TAB2 6964
IRAK1 6131
TAB1 5681
UBE2V1 5637
IKBKG 5377
MAPKAPK2 4054
MAPK11 3826
TAB3 3160
MAP3K7 2395
UBE2N 1936
RIPK2 1025
TRAF6 -229
IRAK2 -9548
NOD1 -12263



Mucopolysaccharidoses

Mucopolysaccharidoses
684
set Mucopolysaccharidoses
setSize 11
pANOVA 0.00883
s.dist 0.456
p.adjustANOVA 0.0241



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNS 9360
GLB1 8725
GUSB 7723
ARSB 7572
GALNS 7102
SGSH 5912
HYAL1 4164
HGSNAT 1867
IDS -2621
NAGLU -4761
IDUA -5830

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNS 9360
GLB1 8725
GUSB 7723
ARSB 7572
GALNS 7102
SGSH 5912
HYAL1 4164
HGSNAT 1867
IDS -2621
NAGLU -4761
IDUA -5830



Platelet degranulation

Platelet degranulation
832
set Platelet degranulation
setSize 106
pANOVA 5.81e-16
s.dist 0.455
p.adjustANOVA 5.29e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
F5 9485
CYB5R1 9460
CD36 9444
CLU 9371
APLP2 9347
QSOX1 9298
CD63 9287
ALDOA 9249
LHFPL2 9224
FERMT3 9223
APP 9177
SERPINA1 9168
ACTN1 9094
STXBP2 9035
ITGA2B 8893
F13A1 8876
HGF 8863
TOR4A 8861
VTI1B 8850
LAMP2 8786

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
F5 9485
CYB5R1 9460
CD36 9444
CLU 9371
APLP2 9347
QSOX1 9298
CD63 9287
ALDOA 9249
LHFPL2 9224
FERMT3 9223
APP 9177
SERPINA1 9168
ACTN1 9094
STXBP2 9035
ITGA2B 8893
F13A1 8876
HGF 8863
TOR4A 8861
VTI1B 8850
LAMP2 8786
SRGN 8761
TIMP1 8677
TLN1 8525
CLEC3B 8480
SELP 8457
ITGB3 8291
FN1 8284
SYTL4 8256
ANXA5 8210
CFL1 8186
EGF 8179
CAP1 8111
GAS6 8063
LY6G6F 8023
ORM1 7971
CALU 7894
PECAM1 7855
SCCPDH 7787
PROS1 7758
MMRN1 7714
SERPINE1 7483
VEGFA 7467
ABCC4 7434
TAGLN2 7367
SPARC 7339
VCL 7328
PSAP 7145
HSPA5 7029
F8 7022
WDR1 6976
VEGFC 6906
VWF 6641
TUBA4A 6484
GTPBP2 6331
TMSB4X 6295
PPBP 6042
THBS1 5951
CD9 5940
PF4 5707
A1BG 5559
PFN1 5459
PHACTR2 5410
PDGFA 5293
ECM1 5176
TGFB1 5153
ACTN4 5049
OLA1 4914
CD109 4316
ALB 3668
RAB27B 3386
ENDOD1 3361
TIMP3 3296
CHID1 2811
MANF 2550
PLEK 1999
CFD 1984
APOOL 1609
TTN 1195
TF 1102
FLNA 483
TMX3 -775
PLG -1977
PCYOX1L -2009
CALM1 -2081
ORM2 -2564
MAGED2 -2687
ITIH3 -3017
SOD1 -4862
ITIH4 -6208
SERPINF2 -6574
BRPF3 -6615
PPIA -6766
TGFB2 -7492
SELENOP -7771
NHLRC2 -7835
TGFB3 -7891
VEGFB -7929
TEX264 -8366
CDC37L1 -8470
PDGFB -8577
A2M -9870
FAM3C -10062
HABP4 -10921
CTSW -11117
SERPING1 -11197
LGALS3BP -11459



IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
513
set IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
setSize 15
pANOVA 0.0023
s.dist 0.455
p.adjustANOVA 0.00805



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD14 9097
TLR4 9016
LY96 8795
TAB2 6964
UBB 6639
TICAM2 6335
TICAM1 6307
TAB1 5681
UBC 4439
TAB3 3160
MAP3K7 2395
UBA52 1121
TRAF6 -229
RPS27A -6938
IRAK2 -9548

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD14 9097
TLR4 9016
LY96 8795
TAB2 6964
UBB 6639
TICAM2 6335
TICAM1 6307
TAB1 5681
UBC 4439
TAB3 3160
MAP3K7 2395
UBA52 1121
TRAF6 -229
RPS27A -6938
IRAK2 -9548



Lagging Strand Synthesis

Lagging Strand Synthesis
593
set Lagging Strand Synthesis
setSize 20
pANOVA 0.000463
s.dist -0.452
p.adjustANOVA 0.00215



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLA1 -12150
RPA1 -12004
RFC5 -11712
POLA2 -11575
LIG1 -11053
RFC4 -10702
FEN1 -10593
RFC3 -10489
POLD2 -10351
PRIM1 -10191
RPA3 -8911
RFC1 -7437
RPA2 -6306
PCNA -5969
PRIM2 -5575
DNA2 -2858
POLD1 204
RFC2 4948
POLD4 6336
POLD3 8885

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA1 -12150
RPA1 -12004
RFC5 -11712
POLA2 -11575
LIG1 -11053
RFC4 -10702
FEN1 -10593
RFC3 -10489
POLD2 -10351
PRIM1 -10191
RPA3 -8911
RFC1 -7437
RPA2 -6306
PCNA -5969
PRIM2 -5575
DNA2 -2858
POLD1 204
RFC2 4948
POLD4 6336
POLD3 8885



Prolonged ERK activation events

Prolonged ERK activation events
864
set Prolonged ERK activation events
setSize 13
pANOVA 0.00476
s.dist 0.452
p.adjustANOVA 0.0147



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAP2K1 9063
MAPK3 8953
CRK 8906
MAPK1 7493
RAP1A 7305
KIDINS220 7069
MAP2K2 6794
YWHAB 6385
CRKL 3966
BRAF 1308
FRS2 -3433
NTRK1 -8193
RAPGEF1 -9826

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAP2K1 9063
MAPK3 8953
CRK 8906
MAPK1 7493
RAP1A 7305
KIDINS220 7069
MAP2K2 6794
YWHAB 6385
CRKL 3966
BRAF 1308
FRS2 -3433
NTRK1 -8193
RAPGEF1 -9826



Infection with Mycobacterium tuberculosis

Infection with Mycobacterium tuberculosis
525
set Infection with Mycobacterium tuberculosis
setSize 26
pANOVA 7.2e-05
s.dist 0.45
p.adjustANOVA 0.000439



Top enriched genes

Top 20 genes
GeneID Gene Rank
TLR2 9103
MAPK3 8953
ENO1 8890
RAB7A 8742
PGK1 8672
TRIM27 8142
ATP6V1H 8064
GSK3A 7760
MAPK1 7493
RAB5A 7103
UBB 6639
LTF 6306
CORO1A 5178
CTSG 5115
HGS 4513
UBC 4439
MRC1 3109
KPNB1 2430
SFPQ 2253
KPNA1 1296

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TLR2 9103
MAPK3 8953
ENO1 8890
RAB7A 8742
PGK1 8672
TRIM27 8142
ATP6V1H 8064
GSK3A 7760
MAPK1 7493
RAB5A 7103
UBB 6639
LTF 6306
CORO1A 5178
CTSG 5115
HGS 4513
UBC 4439
MRC1 3109
KPNB1 2430
SFPQ 2253
KPNA1 1296
UBA52 1121
VPS33B -2091
DUSP16 -6655
B2M -6920
RPS27A -6938
RNF213 -11905



WNT5A-dependent internalization of FZD4

WNT5A-dependent internalization of FZD4
1327
set WNT5A-dependent internalization of FZD4
setSize 13
pANOVA 0.00502
s.dist 0.449
p.adjustANOVA 0.0153



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLTC 9000
AP2M1 8627
ARRB2 8490
CLTA 8376
AP2S1 8026
AP2A2 7257
PRKCB 7097
AP2A1 6832
CLTB 6084
PRKCA 1132
AP2B1 -2709
DVL2 -11152
FZD4 -11650

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLTC 9000
AP2M1 8627
ARRB2 8490
CLTA 8376
AP2S1 8026
AP2A2 7257
PRKCB 7097
AP2A1 6832
CLTB 6084
PRKCA 1132
AP2B1 -2709
DVL2 -11152
FZD4 -11650



Packaging Of Telomere Ends

Packaging Of Telomere Ends
803
set Packaging Of Telomere Ends
setSize 20
pANOVA 0.000517
s.dist 0.448
p.adjustANOVA 0.00235



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AJ 9374
H2BC21 9283
H2BC12 9051
H2BC5 8003
H2AC6 7934
H2BC11 7912
H2BC4 7389
H2BC17 7285
H2AZ1 6036
H2BC9 5394
H2BC15 5312
TERF2IP 5040
H2AC20 4972
TINF2 4592
H2AZ2 -1209
TERF1 -3601
POT1 -4355
TERF2 -4464
H2BU1 -6555
ACD -7800

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AJ 9374
H2BC21 9283
H2BC12 9051
H2BC5 8003
H2AC6 7934
H2BC11 7912
H2BC4 7389
H2BC17 7285
H2AZ1 6036
H2BC9 5394
H2BC15 5312
TERF2IP 5040
H2AC20 4972
TINF2 4592
H2AZ2 -1209
TERF1 -3601
POT1 -4355
TERF2 -4464
H2BU1 -6555
ACD -7800



ATF6 (ATF6-alpha) activates chaperone genes

ATF6 (ATF6-alpha) activates chaperone genes
20
set ATF6 (ATF6-alpha) activates chaperone genes
setSize 10
pANOVA 0.0144
s.dist 0.447
p.adjustANOVA 0.0352



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATF6 8464
NFYC 7653
HSPA5 7029
CALR 6340
ATF4 6237
DDIT3 4906
NFYA 3506
HSP90B1 2059
XBP1 -1579
NFYB -9964

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATF6 8464
NFYC 7653
HSPA5 7029
CALR 6340
ATF4 6237
DDIT3 4906
NFYA 3506
HSP90B1 2059
XBP1 -1579
NFYB -9964



Membrane binding and targetting of GAG proteins

Membrane binding and targetting of GAG proteins
633
set Membrane binding and targetting of GAG proteins
setSize 13
pANOVA 0.0054
s.dist 0.446
p.adjustANOVA 0.0162



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBAP1 8701
VPS37C 8010
TSG101 7786
MVB12A 7400
UBB 6639
VPS37A 6467
MVB12B 5175
UBC 4439
VPS28 4199
VPS37B 3908
UBA52 1121
RPS27A -6938
NMT2 -12035

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBAP1 8701
VPS37C 8010
TSG101 7786
MVB12A 7400
UBB 6639
VPS37A 6467
MVB12B 5175
UBC 4439
VPS28 4199
VPS37B 3908
UBA52 1121
RPS27A -6938
NMT2 -12035



Synthesis And Processing Of GAG, GAGPOL Polyproteins

Synthesis And Processing Of GAG, GAGPOL Polyproteins
1164
set Synthesis And Processing Of GAG, GAGPOL Polyproteins
setSize 13
pANOVA 0.0054
s.dist 0.446
p.adjustANOVA 0.0162



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBAP1 8701
VPS37C 8010
TSG101 7786
MVB12A 7400
UBB 6639
VPS37A 6467
MVB12B 5175
UBC 4439
VPS28 4199
VPS37B 3908
UBA52 1121
RPS27A -6938
NMT2 -12035

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBAP1 8701
VPS37C 8010
TSG101 7786
MVB12A 7400
UBB 6639
VPS37A 6467
MVB12B 5175
UBC 4439
VPS28 4199
VPS37B 3908
UBA52 1121
RPS27A -6938
NMT2 -12035



Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Resolution of AP sites via the multiple-nucleotide patch replacement pathway
1000
set Resolution of AP sites via the multiple-nucleotide patch replacement pathway
setSize 24
pANOVA 0.000157
s.dist -0.446
p.adjustANOVA 0.000844



Top enriched genes

Top 20 genes
GeneID Gene Rank
PARP2 -12221
RPA1 -12004
PARP1 -11764
RFC5 -11712
POLE3 -11581
LIG1 -11053
RFC4 -10702
FEN1 -10593
RFC3 -10489
POLD2 -10351
APEX1 -10332
POLE2 -9941
RPA3 -8911
POLE -7579
POLB -7537
RFC1 -7437
RPA2 -6306
PCNA -5969
PARG -658
POLD1 204

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PARP2 -12221
RPA1 -12004
PARP1 -11764
RFC5 -11712
POLE3 -11581
LIG1 -11053
RFC4 -10702
FEN1 -10593
RFC3 -10489
POLD2 -10351
APEX1 -10332
POLE2 -9941
RPA3 -8911
POLE -7579
POLB -7537
RFC1 -7437
RPA2 -6306
PCNA -5969
PARG -658
POLD1 204
RFC2 4948
POLE4 5518
POLD4 6336
POLD3 8885



Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
984
set Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
setSize 11
pANOVA 0.0109
s.dist 0.443
p.adjustANOVA 0.0279



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKACA 9429
PFKFB4 9271
PFKFB3 8656
PPP2CA 8234
PFKFB2 7946
PPP2CB 7712
PPP2R1A 4589
PPP2R5D 2421
PPP2R1B -241
PFKFB1 -8393
PRKACB -11959

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKACA 9429
PFKFB4 9271
PFKFB3 8656
PPP2CA 8234
PFKFB2 7946
PPP2CB 7712
PPP2R1A 4589
PPP2R5D 2421
PPP2R1B -241
PFKFB1 -8393
PRKACB -11959



Signal amplification

Signal amplification
1072
set Signal amplification
setSize 28
pANOVA 5.41e-05
s.dist 0.441
p.adjustANOVA 0.000345



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNA15 9452
GNG10 9349
PLA2G4A 9180
MAPK14 9104
GNAQ 8993
GNG5 8815
GNB1 8294
GNB2 8141
GNAI2 8075
GNAI3 7953
P2RY1 7852
GNB4 7336
GNG11 6495
GNA13 5836
TBXA2R 5148
P2RY12 4821
GNG8 4296
GNAI1 3329
GNA11 3259
GNG3 890

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNA15 9452
GNG10 9349
PLA2G4A 9180
MAPK14 9104
GNAQ 8993
GNG5 8815
GNB1 8294
GNB2 8141
GNAI2 8075
GNAI3 7953
P2RY1 7852
GNB4 7336
GNG11 6495
GNA13 5836
TBXA2R 5148
P2RY12 4821
GNG8 4296
GNAI1 3329
GNA11 3259
GNG3 890
GNB5 512
GNG4 -2154
GNB3 -2397
AAMP -3636
GNG7 -5198
GNG2 -7795
SRC -8820
GNGT2 -12086



Biotin transport and metabolism

Biotin transport and metabolism
114
set Biotin transport and metabolism
setSize 11
pANOVA 0.0116
s.dist -0.44
p.adjustANOVA 0.0291



Top enriched genes

Top 20 genes
GeneID Gene Rank
BTD -12170
MCCC2 -11857
HLCS -11710
ACACB -9957
MCCC1 -8976
PCCA -8664
PCCB -7976
PDZD11 -6288
SLC5A6 -5629
ACACA 5315
PC 9263

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BTD -12170
MCCC2 -11857
HLCS -11710
ACACB -9957
MCCC1 -8976
PCCA -8664
PCCB -7976
PDZD11 -6288
SLC5A6 -5629
ACACA 5315
PC 9263



MyD88:MAL(TIRAP) cascade initiated on plasma membrane

MyD88:MAL(TIRAP) cascade initiated on plasma membrane
690
set MyD88:MAL(TIRAP) cascade initiated on plasma membrane
setSize 92
pANOVA 3.03e-13
s.dist 0.44
p.adjustANOVA 1.53e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A12 9515
CD36 9444
NKIRAS2 9353
DUSP3 9280
APP 9177
IRAK3 9107
MAPK14 9104
TLR2 9103
CD14 9097
MAP2K1 9063
TLR4 9016
MAPK3 8953
TLR1 8932
MAP2K6 8887
TLR6 8840
LY96 8795
MAP2K3 8748
NOD2 8442
MAPKAPK3 8382
PELI2 8314

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A12 9515
CD36 9444
NKIRAS2 9353
DUSP3 9280
APP 9177
IRAK3 9107
MAPK14 9104
TLR2 9103
CD14 9097
MAP2K1 9063
TLR4 9016
MAPK3 8953
TLR1 8932
MAP2K6 8887
TLR6 8840
LY96 8795
MAP2K3 8748
NOD2 8442
MAPKAPK3 8382
PELI2 8314
PPP2CA 8234
MYD88 8136
MEF2A 8009
CHUK 7966
PELI3 7716
PPP2CB 7712
RPS6KA1 7695
MAPK1 7493
BTK 7206
TAB2 6964
MAP2K4 6866
NFKBIA 6807
PELI1 6715
UBB 6639
NFKB1 6277
FBXW11 6196
MAP3K8 6160
IRAK1 6131
ATF1 5706
TAB1 5681
TIRAP 5640
UBE2V1 5637
TNIP2 5552
FOS 5460
IKBKG 5377
MAP3K1 5121
ECSIT 4918
PPP2R1A 4589
UBC 4439
DUSP6 4357
MAPK10 4325
SKP1 4287
MAPKAPK2 4054
SOCS1 3947
MAPK11 3826
JUN 3722
TAB3 3160
RPS6KA2 3087
RPS6KA3 2973
PPP2R5D 2421
MAP3K7 2395
ATF2 2085
UBE2N 1936
MAP2K7 1654
AGER 1294
VRK3 1281
UBA52 1121
ELK1 1040
RIPK2 1025
NKIRAS1 375
NFKBIB -152
TRAF6 -229
PPP2R1B -241
HMGB1 -252
MEF2C -293
NFKB2 -1165
MAPK7 -1337
CREB1 -1378
RELA -1803
DUSP7 -3211
BTRC -4924
IKBKB -5386
S100B -5457
DUSP4 -6287
RPS27A -6938
MAPK9 -7068
MAPK8 -9428
IRAK2 -9548
SIGIRR -10752
CUL1 -11330
RPS6KA5 -11594
NOD1 -12263



Toll Like Receptor 2 (TLR2) Cascade

Toll Like Receptor 2 (TLR2) Cascade
1239
set Toll Like Receptor 2 (TLR2) Cascade
setSize 92
pANOVA 3.03e-13
s.dist 0.44
p.adjustANOVA 1.53e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A12 9515
CD36 9444
NKIRAS2 9353
DUSP3 9280
APP 9177
IRAK3 9107
MAPK14 9104
TLR2 9103
CD14 9097
MAP2K1 9063
TLR4 9016
MAPK3 8953
TLR1 8932
MAP2K6 8887
TLR6 8840
LY96 8795
MAP2K3 8748
NOD2 8442
MAPKAPK3 8382
PELI2 8314

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A12 9515
CD36 9444
NKIRAS2 9353
DUSP3 9280
APP 9177
IRAK3 9107
MAPK14 9104
TLR2 9103
CD14 9097
MAP2K1 9063
TLR4 9016
MAPK3 8953
TLR1 8932
MAP2K6 8887
TLR6 8840
LY96 8795
MAP2K3 8748
NOD2 8442
MAPKAPK3 8382
PELI2 8314
PPP2CA 8234
MYD88 8136
MEF2A 8009
CHUK 7966
PELI3 7716
PPP2CB 7712
RPS6KA1 7695
MAPK1 7493
BTK 7206
TAB2 6964
MAP2K4 6866
NFKBIA 6807
PELI1 6715
UBB 6639
NFKB1 6277
FBXW11 6196
MAP3K8 6160
IRAK1 6131
ATF1 5706
TAB1 5681
TIRAP 5640
UBE2V1 5637
TNIP2 5552
FOS 5460
IKBKG 5377
MAP3K1 5121
ECSIT 4918
PPP2R1A 4589
UBC 4439
DUSP6 4357
MAPK10 4325
SKP1 4287
MAPKAPK2 4054
SOCS1 3947
MAPK11 3826
JUN 3722
TAB3 3160
RPS6KA2 3087
RPS6KA3 2973
PPP2R5D 2421
MAP3K7 2395
ATF2 2085
UBE2N 1936
MAP2K7 1654
AGER 1294
VRK3 1281
UBA52 1121
ELK1 1040
RIPK2 1025
NKIRAS1 375
NFKBIB -152
TRAF6 -229
PPP2R1B -241
HMGB1 -252
MEF2C -293
NFKB2 -1165
MAPK7 -1337
CREB1 -1378
RELA -1803
DUSP7 -3211
BTRC -4924
IKBKB -5386
S100B -5457
DUSP4 -6287
RPS27A -6938
MAPK9 -7068
MAPK8 -9428
IRAK2 -9548
SIGIRR -10752
CUL1 -11330
RPS6KA5 -11594
NOD1 -12263



Toll Like Receptor TLR1:TLR2 Cascade

Toll Like Receptor TLR1:TLR2 Cascade
1245
set Toll Like Receptor TLR1:TLR2 Cascade
setSize 92
pANOVA 3.03e-13
s.dist 0.44
p.adjustANOVA 1.53e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A12 9515
CD36 9444
NKIRAS2 9353
DUSP3 9280
APP 9177
IRAK3 9107
MAPK14 9104
TLR2 9103
CD14 9097
MAP2K1 9063
TLR4 9016
MAPK3 8953
TLR1 8932
MAP2K6 8887
TLR6 8840
LY96 8795
MAP2K3 8748
NOD2 8442
MAPKAPK3 8382
PELI2 8314

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A12 9515
CD36 9444
NKIRAS2 9353
DUSP3 9280
APP 9177
IRAK3 9107
MAPK14 9104
TLR2 9103
CD14 9097
MAP2K1 9063
TLR4 9016
MAPK3 8953
TLR1 8932
MAP2K6 8887
TLR6 8840
LY96 8795
MAP2K3 8748
NOD2 8442
MAPKAPK3 8382
PELI2 8314
PPP2CA 8234
MYD88 8136
MEF2A 8009
CHUK 7966
PELI3 7716
PPP2CB 7712
RPS6KA1 7695
MAPK1 7493
BTK 7206
TAB2 6964
MAP2K4 6866
NFKBIA 6807
PELI1 6715
UBB 6639
NFKB1 6277
FBXW11 6196
MAP3K8 6160
IRAK1 6131
ATF1 5706
TAB1 5681
TIRAP 5640
UBE2V1 5637
TNIP2 5552
FOS 5460
IKBKG 5377
MAP3K1 5121
ECSIT 4918
PPP2R1A 4589
UBC 4439
DUSP6 4357
MAPK10 4325
SKP1 4287
MAPKAPK2 4054
SOCS1 3947
MAPK11 3826
JUN 3722
TAB3 3160
RPS6KA2 3087
RPS6KA3 2973
PPP2R5D 2421
MAP3K7 2395
ATF2 2085
UBE2N 1936
MAP2K7 1654
AGER 1294
VRK3 1281
UBA52 1121
ELK1 1040
RIPK2 1025
NKIRAS1 375
NFKBIB -152
TRAF6 -229
PPP2R1B -241
HMGB1 -252
MEF2C -293
NFKB2 -1165
MAPK7 -1337
CREB1 -1378
RELA -1803
DUSP7 -3211
BTRC -4924
IKBKB -5386
S100B -5457
DUSP4 -6287
RPS27A -6938
MAPK9 -7068
MAPK8 -9428
IRAK2 -9548
SIGIRR -10752
CUL1 -11330
RPS6KA5 -11594
NOD1 -12263



Toll Like Receptor TLR6:TLR2 Cascade

Toll Like Receptor TLR6:TLR2 Cascade
1246
set Toll Like Receptor TLR6:TLR2 Cascade
setSize 92
pANOVA 3.03e-13
s.dist 0.44
p.adjustANOVA 1.53e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A12 9515
CD36 9444
NKIRAS2 9353
DUSP3 9280
APP 9177
IRAK3 9107
MAPK14 9104
TLR2 9103
CD14 9097
MAP2K1 9063
TLR4 9016
MAPK3 8953
TLR1 8932
MAP2K6 8887
TLR6 8840
LY96 8795
MAP2K3 8748
NOD2 8442
MAPKAPK3 8382
PELI2 8314

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A12 9515
CD36 9444
NKIRAS2 9353
DUSP3 9280
APP 9177
IRAK3 9107
MAPK14 9104
TLR2 9103
CD14 9097
MAP2K1 9063
TLR4 9016
MAPK3 8953
TLR1 8932
MAP2K6 8887
TLR6 8840
LY96 8795
MAP2K3 8748
NOD2 8442
MAPKAPK3 8382
PELI2 8314
PPP2CA 8234
MYD88 8136
MEF2A 8009
CHUK 7966
PELI3 7716
PPP2CB 7712
RPS6KA1 7695
MAPK1 7493
BTK 7206
TAB2 6964
MAP2K4 6866
NFKBIA 6807
PELI1 6715
UBB 6639
NFKB1 6277
FBXW11 6196
MAP3K8 6160
IRAK1 6131
ATF1 5706
TAB1 5681
TIRAP 5640
UBE2V1 5637
TNIP2 5552
FOS 5460
IKBKG 5377
MAP3K1 5121
ECSIT 4918
PPP2R1A 4589
UBC 4439
DUSP6 4357
MAPK10 4325
SKP1 4287
MAPKAPK2 4054
SOCS1 3947
MAPK11 3826
JUN 3722
TAB3 3160
RPS6KA2 3087
RPS6KA3 2973
PPP2R5D 2421
MAP3K7 2395
ATF2 2085
UBE2N 1936
MAP2K7 1654
AGER 1294
VRK3 1281
UBA52 1121
ELK1 1040
RIPK2 1025
NKIRAS1 375
NFKBIB -152
TRAF6 -229
PPP2R1B -241
HMGB1 -252
MEF2C -293
NFKB2 -1165
MAPK7 -1337
CREB1 -1378
RELA -1803
DUSP7 -3211
BTRC -4924
IKBKB -5386
S100B -5457
DUSP4 -6287
RPS27A -6938
MAPK9 -7068
MAPK8 -9428
IRAK2 -9548
SIGIRR -10752
CUL1 -11330
RPS6KA5 -11594
NOD1 -12263



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.0               GGally_2.1.1               
##  [3] beeswarm_0.3.1              gtools_3.8.2               
##  [5] echarts4r_0.4.0             topconfects_1.6.0          
##  [7] limma_3.46.0                eulerr_6.1.0               
##  [9] mitch_1.2.2                 MASS_7.3-53.1              
## [11] fgsea_1.16.0                gplots_3.1.1               
## [13] DESeq2_1.30.0               SummarizedExperiment_1.20.0
## [15] Biobase_2.50.0              MatrixGenerics_1.2.0       
## [17] matrixStats_0.58.0          GenomicRanges_1.42.0       
## [19] GenomeInfoDb_1.26.0         IRanges_2.24.0             
## [21] S4Vectors_0.28.0            BiocGenerics_0.36.0        
## [23] reshape2_1.4.4              forcats_0.5.1              
## [25] stringr_1.4.0               dplyr_1.0.5                
## [27] purrr_0.3.4                 readr_1.4.0                
## [29] tidyr_1.1.3                 tibble_3.1.0               
## [31] ggplot2_3.3.3               tidyverse_1.3.0            
## [33] zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] colorspace_2.0-0       ellipsis_0.3.1         rprojroot_2.0.2       
##   [4] XVector_0.30.0         fs_1.5.0               rstudioapi_0.13       
##   [7] farver_2.1.0           bit64_4.0.5            AnnotationDbi_1.52.0  
##  [10] fansi_0.4.2            lubridate_1.7.10       xml2_1.3.2            
##  [13] splines_4.0.3          cachem_1.0.4           geneplotter_1.68.0    
##  [16] knitr_1.31             polyclip_1.10-0        jsonlite_1.7.2        
##  [19] broom_0.7.5            annotate_1.68.0        dbplyr_2.1.0          
##  [22] shiny_1.6.0            compiler_4.0.3         httr_1.4.2            
##  [25] backports_1.2.1        assertthat_0.2.1       Matrix_1.3-2          
##  [28] fastmap_1.1.0          cli_2.3.1              later_1.1.0.1         
##  [31] htmltools_0.5.1.1      tools_4.0.3            gtable_0.3.0          
##  [34] glue_1.4.2             GenomeInfoDbData_1.2.4 fastmatch_1.1-0       
##  [37] Rcpp_1.0.6             cellranger_1.1.0       jquerylib_0.1.3       
##  [40] vctrs_0.3.6            polylabelr_0.2.0       xfun_0.22             
##  [43] ps_1.6.0               testthat_3.0.2         rvest_1.0.0           
##  [46] mime_0.10              lifecycle_1.0.0        XML_3.99-0.6          
##  [49] zlibbioc_1.36.0        scales_1.1.1           promises_1.2.0.1      
##  [52] hms_1.0.0              RColorBrewer_1.1-2     yaml_2.2.1            
##  [55] memoise_2.0.0          gridExtra_2.3          sass_0.3.1            
##  [58] reshape_0.8.8          stringi_1.5.3          RSQLite_2.2.4         
##  [61] highr_0.8              genefilter_1.72.0      desc_1.3.0            
##  [64] caTools_1.18.1         BiocParallel_1.24.1    rlang_0.4.10          
##  [67] pkgconfig_2.0.3        bitops_1.0-6           evaluate_0.14         
##  [70] lattice_0.20-41        labeling_0.4.2         htmlwidgets_1.5.3     
##  [73] bit_4.0.4              tidyselect_1.1.0       plyr_1.8.6            
##  [76] magrittr_2.0.1         R6_2.5.0               generics_0.1.0        
##  [79] DelayedArray_0.16.0    DBI_1.1.1              pillar_1.5.1          
##  [82] haven_2.3.1            withr_2.4.1            survival_3.2-10       
##  [85] RCurl_1.98-1.3         modelr_0.1.8           crayon_1.4.1          
##  [88] KernSmooth_2.23-18     utf8_1.2.1             rmarkdown_2.7         
##  [91] locfit_1.5-9.4         grid_4.0.3             readxl_1.3.1          
##  [94] data.table_1.14.0      blob_1.2.1             reprex_1.0.0          
##  [97] digest_0.6.27          xtable_1.8-4           httpuv_1.5.5          
## [100] munsell_0.5.0          bslib_0.2.4

END of report