date generated: 2020-07-02

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                   x
## A1BG     -0.2700849
## A1BG-AS1 -0.1338135
## A1CF     -0.2637826
## A2M      -0.9092766
## A2M-AS1  -1.3532049
## A2ML1     1.3356390

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genesets 2400
num_genes_in_profile 21631
duplicated_genes_present 0
num_profile_genes_in_sets 8419
num_profile_genes_not_in_sets 13212

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2400
num_genesets_excluded 1039
num_genesets_included 1361

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 100 gene sets

set setSize pANOVA s.dist p.adjustANOVA
IRAK4 deficiency (TLR2/4) 10 1.74e-06 0.873 2.19e-05
MyD88 deficiency (TLR2/4) 10 1.74e-06 0.873 2.19e-05
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 4.98e-06 0.761 5.42e-05
alpha-linolenic acid (ALA) metabolism 12 4.98e-06 0.761 5.42e-05
Translocation of ZAP-70 to Immunological synapse 24 3.58e-10 -0.739 9.19e-09
Peptide chain elongation 88 1.45e-30 -0.708 1.97e-28
Eukaryotic Translation Elongation 93 7.20e-32 -0.704 1.22e-29
Selenocysteine synthesis 92 3.34e-30 -0.688 4.13e-28
Viral mRNA Translation 88 1.86e-28 -0.681 1.81e-26
Regulation of TLR by endogenous ligand 11 1.08e-04 0.674 7.76e-04
Eukaryotic Translation Termination 92 6.71e-29 -0.672 7.03e-27
Formation of a pool of free 40S subunits 100 5.50e-31 -0.669 8.31e-29
Hyaluronan uptake and degradation 12 8.49e-05 0.655 6.46e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.72e-04 0.654 1.13e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.18e-27 -0.646 1.98e-25
RHO GTPases Activate ROCKs 18 2.75e-06 0.638 3.23e-05
Uptake and function of anthrax toxins 10 5.01e-04 0.635 2.74e-03
MET activates RAP1 and RAC1 10 5.66e-04 0.629 3.07e-03
VLDLR internalisation and degradation 12 2.06e-04 0.619 1.31e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 7.04e-04 0.619 3.66e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 9.85e-26 -0.606 6.71e-24
Platelet sensitization by LDL 16 3.81e-05 0.595 3.29e-04
PD-1 signaling 28 5.11e-08 -0.595 9.28e-07
L13a-mediated translational silencing of Ceruloplasmin expression 110 4.86e-27 -0.594 4.14e-25
GTP hydrolysis and joining of the 60S ribosomal subunit 111 5.73e-27 -0.590 4.59e-25
Major pathway of rRNA processing in the nucleolus and cytosol 180 6.36e-42 -0.585 1.73e-39
rRNA processing in the nucleus and cytosol 190 1.07e-43 -0.582 4.84e-41
Advanced glycosylation endproduct receptor signaling 12 6.12e-04 0.571 3.28e-03
RHO GTPases Activate WASPs and WAVEs 35 4.96e-09 0.571 1.11e-07
Nucleobase biosynthesis 13 3.95e-04 -0.567 2.26e-03
Selenoamino acid metabolism 114 2.43e-25 -0.563 1.44e-23
Gap junction trafficking 13 4.49e-04 0.562 2.50e-03
Formation of the ternary complex, and subsequently, the 43S complex 51 5.32e-12 -0.558 1.81e-10
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 5.00e-04 0.558 2.74e-03
RHO GTPases activate IQGAPs 11 1.37e-03 0.557 6.34e-03
Cap-dependent Translation Initiation 118 1.43e-25 -0.556 8.87e-24
Eukaryotic Translation Initiation 118 1.43e-25 -0.556 8.87e-24
Retrograde neurotrophin signalling 12 8.97e-04 0.554 4.51e-03
Activation of the pre-replicative complex 32 8.06e-08 -0.548 1.37e-06
Signal transduction by L1 20 2.34e-05 0.546 2.13e-04
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 1.83e-03 0.543 8.02e-03
rRNA modification in the nucleus and cytosol 59 6.36e-13 -0.541 2.55e-11
Unwinding of DNA 12 1.17e-03 -0.541 5.64e-03
Processive synthesis on the lagging strand 15 2.86e-04 -0.541 1.70e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 4.00e-23 -0.536 2.10e-21
Nonsense-Mediated Decay (NMD) 114 4.00e-23 -0.536 2.10e-21
WNT5A-dependent internalization of FZD4 13 8.38e-04 0.535 4.27e-03
rRNA processing 217 6.16e-42 -0.533 1.73e-39
Influenza Viral RNA Transcription and Replication 135 1.03e-26 -0.533 7.76e-25
DNA strand elongation 32 2.09e-07 -0.530 3.28e-06
Erythrocytes take up carbon dioxide and release oxygen 12 1.68e-03 0.524 7.46e-03
O2/CO2 exchange in erythrocytes 12 1.68e-03 0.524 7.46e-03
Lagging Strand Synthesis 20 5.15e-05 -0.523 4.13e-04
RHO GTPases activate CIT 18 1.23e-04 0.523 8.50e-04
Phosphorylation of CD3 and TCR zeta chains 27 3.27e-06 -0.517 3.74e-05
COPI-independent Golgi-to-ER retrograde traffic 33 3.45e-07 0.513 4.83e-06
Removal of the Flap Intermediate 14 9.38e-04 -0.511 4.66e-03
Prolonged ERK activation events 13 1.51e-03 0.508 6.84e-03
SRP-dependent cotranslational protein targeting to membrane 111 2.12e-20 -0.508 9.93e-19
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.12e-03 0.503 5.44e-03
Neutrophil degranulation 458 2.74e-76 0.502 3.73e-73
Generation of second messenger molecules 38 8.71e-08 -0.502 1.46e-06
Erythropoietin activates RAS 13 1.77e-03 0.501 7.80e-03
EPHB-mediated forward signaling 32 9.70e-07 0.500 1.26e-05
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 2.43e-05 -0.498 2.19e-04
RHO GTPases activate PAKs 20 1.18e-04 0.497 8.20e-04
PCNA-Dependent Long Patch Base Excision Repair 21 8.34e-05 -0.496 6.38e-04
Sema4D in semaphorin signaling 22 5.71e-05 0.496 4.47e-04
Detoxification of Reactive Oxygen Species 32 1.82e-06 0.487 2.27e-05
Trafficking of GluR2-containing AMPA receptors 12 3.62e-03 0.485 1.36e-02
Purine ribonucleoside monophosphate biosynthesis 10 7.97e-03 -0.485 2.56e-02
p130Cas linkage to MAPK signaling for integrins 11 5.40e-03 0.484 1.87e-02
SLBP independent Processing of Histone Pre-mRNAs 10 8.00e-03 -0.484 2.57e-02
Heme degradation 10 8.43e-03 0.481 2.66e-02
Hyaluronan metabolism 15 1.26e-03 0.481 5.90e-03
Sema4D induced cell migration and growth-cone collapse 19 2.90e-04 0.480 1.71e-03
Cargo concentration in the ER 30 5.40e-06 0.480 5.83e-05
CD22 mediated BCR regulation 59 2.23e-10 -0.477 6.06e-09
RHO GTPases Activate NADPH Oxidases 21 1.56e-04 0.477 1.03e-03
Translation initiation complex formation 58 3.57e-10 -0.476 9.19e-09
Ribosomal scanning and start codon recognition 58 5.14e-10 -0.472 1.30e-08
Telomere C-strand (Lagging Strand) Synthesis 34 2.26e-06 -0.468 2.75e-05
Activation of ATR in response to replication stress 37 8.78e-07 -0.467 1.15e-05
GPVI-mediated activation cascade 31 6.96e-06 0.466 7.35e-05
Recycling pathway of L1 26 3.94e-05 0.466 3.35e-04
Pre-NOTCH Processing in Golgi 18 6.77e-04 0.463 3.54e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 8.66e-10 -0.461 2.10e-08
Mucopolysaccharidoses 11 8.26e-03 0.460 2.61e-02
Insulin receptor recycling 21 2.65e-04 0.460 1.60e-03
RHO GTPases activate PKNs 48 3.60e-08 0.459 6.72e-07
BBSome-mediated cargo-targeting to cilium 22 2.16e-04 -0.456 1.36e-03
Influenza Infection 154 1.80e-22 -0.455 9.06e-21
RNA Polymerase I Promoter Opening 19 6.01e-04 0.455 3.23e-03
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 9.15e-03 0.454 2.84e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 2.35e-03 0.454 9.63e-03
Signaling by Erythropoietin 24 1.44e-04 0.448 9.58e-04
Dissolution of Fibrin Clot 12 7.26e-03 0.448 2.36e-02
MAP2K and MAPK activation 34 6.35e-06 0.447 6.75e-05
Diseases associated with the TLR signaling cascade 23 2.19e-04 0.445 1.36e-03
Diseases of Immune System 23 2.19e-04 0.445 1.36e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
IRAK4 deficiency (TLR2/4) 10 1.74e-06 8.73e-01 2.19e-05
MyD88 deficiency (TLR2/4) 10 1.74e-06 8.73e-01 2.19e-05
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 4.98e-06 7.61e-01 5.42e-05
alpha-linolenic acid (ALA) metabolism 12 4.98e-06 7.61e-01 5.42e-05
Translocation of ZAP-70 to Immunological synapse 24 3.58e-10 -7.39e-01 9.19e-09
Peptide chain elongation 88 1.45e-30 -7.08e-01 1.97e-28
Eukaryotic Translation Elongation 93 7.20e-32 -7.04e-01 1.22e-29
Selenocysteine synthesis 92 3.34e-30 -6.88e-01 4.13e-28
Viral mRNA Translation 88 1.86e-28 -6.81e-01 1.81e-26
Regulation of TLR by endogenous ligand 11 1.08e-04 6.74e-01 7.76e-04
Eukaryotic Translation Termination 92 6.71e-29 -6.72e-01 7.03e-27
Formation of a pool of free 40S subunits 100 5.50e-31 -6.69e-01 8.31e-29
Hyaluronan uptake and degradation 12 8.49e-05 6.55e-01 6.46e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.72e-04 6.54e-01 1.13e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.18e-27 -6.46e-01 1.98e-25
RHO GTPases Activate ROCKs 18 2.75e-06 6.38e-01 3.23e-05
Uptake and function of anthrax toxins 10 5.01e-04 6.35e-01 2.74e-03
MET activates RAP1 and RAC1 10 5.66e-04 6.29e-01 3.07e-03
VLDLR internalisation and degradation 12 2.06e-04 6.19e-01 1.31e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 7.04e-04 6.19e-01 3.66e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 9.85e-26 -6.06e-01 6.71e-24
Platelet sensitization by LDL 16 3.81e-05 5.95e-01 3.29e-04
PD-1 signaling 28 5.11e-08 -5.95e-01 9.28e-07
L13a-mediated translational silencing of Ceruloplasmin expression 110 4.86e-27 -5.94e-01 4.14e-25
GTP hydrolysis and joining of the 60S ribosomal subunit 111 5.73e-27 -5.90e-01 4.59e-25
Major pathway of rRNA processing in the nucleolus and cytosol 180 6.36e-42 -5.85e-01 1.73e-39
rRNA processing in the nucleus and cytosol 190 1.07e-43 -5.82e-01 4.84e-41
Advanced glycosylation endproduct receptor signaling 12 6.12e-04 5.71e-01 3.28e-03
RHO GTPases Activate WASPs and WAVEs 35 4.96e-09 5.71e-01 1.11e-07
Nucleobase biosynthesis 13 3.95e-04 -5.67e-01 2.26e-03
Selenoamino acid metabolism 114 2.43e-25 -5.63e-01 1.44e-23
Gap junction trafficking 13 4.49e-04 5.62e-01 2.50e-03
Formation of the ternary complex, and subsequently, the 43S complex 51 5.32e-12 -5.58e-01 1.81e-10
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 5.00e-04 5.58e-01 2.74e-03
RHO GTPases activate IQGAPs 11 1.37e-03 5.57e-01 6.34e-03
Cap-dependent Translation Initiation 118 1.43e-25 -5.56e-01 8.87e-24
Eukaryotic Translation Initiation 118 1.43e-25 -5.56e-01 8.87e-24
Retrograde neurotrophin signalling 12 8.97e-04 5.54e-01 4.51e-03
Activation of the pre-replicative complex 32 8.06e-08 -5.48e-01 1.37e-06
Signal transduction by L1 20 2.34e-05 5.46e-01 2.13e-04
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 1.83e-03 5.43e-01 8.02e-03
rRNA modification in the nucleus and cytosol 59 6.36e-13 -5.41e-01 2.55e-11
Unwinding of DNA 12 1.17e-03 -5.41e-01 5.64e-03
Processive synthesis on the lagging strand 15 2.86e-04 -5.41e-01 1.70e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 4.00e-23 -5.36e-01 2.10e-21
Nonsense-Mediated Decay (NMD) 114 4.00e-23 -5.36e-01 2.10e-21
WNT5A-dependent internalization of FZD4 13 8.38e-04 5.35e-01 4.27e-03
rRNA processing 217 6.16e-42 -5.33e-01 1.73e-39
Influenza Viral RNA Transcription and Replication 135 1.03e-26 -5.33e-01 7.76e-25
DNA strand elongation 32 2.09e-07 -5.30e-01 3.28e-06
Erythrocytes take up carbon dioxide and release oxygen 12 1.68e-03 5.24e-01 7.46e-03
O2/CO2 exchange in erythrocytes 12 1.68e-03 5.24e-01 7.46e-03
Lagging Strand Synthesis 20 5.15e-05 -5.23e-01 4.13e-04
RHO GTPases activate CIT 18 1.23e-04 5.23e-01 8.50e-04
Phosphorylation of CD3 and TCR zeta chains 27 3.27e-06 -5.17e-01 3.74e-05
COPI-independent Golgi-to-ER retrograde traffic 33 3.45e-07 5.13e-01 4.83e-06
Removal of the Flap Intermediate 14 9.38e-04 -5.11e-01 4.66e-03
Prolonged ERK activation events 13 1.51e-03 5.08e-01 6.84e-03
SRP-dependent cotranslational protein targeting to membrane 111 2.12e-20 -5.08e-01 9.93e-19
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.12e-03 5.03e-01 5.44e-03
Neutrophil degranulation 458 2.74e-76 5.02e-01 3.73e-73
Generation of second messenger molecules 38 8.71e-08 -5.02e-01 1.46e-06
Erythropoietin activates RAS 13 1.77e-03 5.01e-01 7.80e-03
EPHB-mediated forward signaling 32 9.70e-07 5.00e-01 1.26e-05
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 2.43e-05 -4.98e-01 2.19e-04
RHO GTPases activate PAKs 20 1.18e-04 4.97e-01 8.20e-04
PCNA-Dependent Long Patch Base Excision Repair 21 8.34e-05 -4.96e-01 6.38e-04
Sema4D in semaphorin signaling 22 5.71e-05 4.96e-01 4.47e-04
Detoxification of Reactive Oxygen Species 32 1.82e-06 4.87e-01 2.27e-05
Trafficking of GluR2-containing AMPA receptors 12 3.62e-03 4.85e-01 1.36e-02
Purine ribonucleoside monophosphate biosynthesis 10 7.97e-03 -4.85e-01 2.56e-02
p130Cas linkage to MAPK signaling for integrins 11 5.40e-03 4.84e-01 1.87e-02
SLBP independent Processing of Histone Pre-mRNAs 10 8.00e-03 -4.84e-01 2.57e-02
Heme degradation 10 8.43e-03 4.81e-01 2.66e-02
Hyaluronan metabolism 15 1.26e-03 4.81e-01 5.90e-03
Sema4D induced cell migration and growth-cone collapse 19 2.90e-04 4.80e-01 1.71e-03
Cargo concentration in the ER 30 5.40e-06 4.80e-01 5.83e-05
CD22 mediated BCR regulation 59 2.23e-10 -4.77e-01 6.06e-09
RHO GTPases Activate NADPH Oxidases 21 1.56e-04 4.77e-01 1.03e-03
Translation initiation complex formation 58 3.57e-10 -4.76e-01 9.19e-09
Ribosomal scanning and start codon recognition 58 5.14e-10 -4.72e-01 1.30e-08
Telomere C-strand (Lagging Strand) Synthesis 34 2.26e-06 -4.68e-01 2.75e-05
Activation of ATR in response to replication stress 37 8.78e-07 -4.67e-01 1.15e-05
GPVI-mediated activation cascade 31 6.96e-06 4.66e-01 7.35e-05
Recycling pathway of L1 26 3.94e-05 4.66e-01 3.35e-04
Pre-NOTCH Processing in Golgi 18 6.77e-04 4.63e-01 3.54e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 8.66e-10 -4.61e-01 2.10e-08
Mucopolysaccharidoses 11 8.26e-03 4.60e-01 2.61e-02
Insulin receptor recycling 21 2.65e-04 4.60e-01 1.60e-03
RHO GTPases activate PKNs 48 3.60e-08 4.59e-01 6.72e-07
BBSome-mediated cargo-targeting to cilium 22 2.16e-04 -4.56e-01 1.36e-03
Influenza Infection 154 1.80e-22 -4.55e-01 9.06e-21
RNA Polymerase I Promoter Opening 19 6.01e-04 4.55e-01 3.23e-03
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 9.15e-03 4.54e-01 2.84e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 2.35e-03 4.54e-01 9.63e-03
Signaling by Erythropoietin 24 1.44e-04 4.48e-01 9.58e-04
Dissolution of Fibrin Clot 12 7.26e-03 4.48e-01 2.36e-02
MAP2K and MAPK activation 34 6.35e-06 4.47e-01 6.75e-05
Diseases associated with the TLR signaling cascade 23 2.19e-04 4.45e-01 1.36e-03
Diseases of Immune System 23 2.19e-04 4.45e-01 1.36e-03
Frs2-mediated activation 11 1.09e-02 4.43e-01 3.25e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.11e-02 -4.42e-01 3.32e-02
Smooth Muscle Contraction 31 2.13e-05 4.41e-01 1.96e-04
Gap junction trafficking and regulation 15 3.16e-03 4.40e-01 1.22e-02
Telomere C-strand synthesis initiation 13 6.31e-03 -4.37e-01 2.10e-02
Regulation of IFNG signaling 14 4.63e-03 4.37e-01 1.66e-02
ERKs are inactivated 13 6.48e-03 4.36e-01 2.14e-02
Negative regulation of MET activity 18 1.39e-03 4.35e-01 6.43e-03
tRNA modification in the nucleus and cytosol 43 8.39e-07 -4.34e-01 1.12e-05
Leading Strand Synthesis 14 5.15e-03 -4.32e-01 1.80e-02
Polymerase switching 14 5.15e-03 -4.32e-01 1.80e-02
Signaling by high-kinase activity BRAF mutants 31 3.31e-05 4.31e-01 2.89e-04
Endosomal Sorting Complex Required For Transport (ESCRT) 29 6.20e-05 4.30e-01 4.82e-04
AKT phosphorylates targets in the cytosol 14 5.71e-03 4.27e-01 1.94e-02
IRAK1 recruits IKK complex 10 1.96e-02 4.26e-01 5.25e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 1.96e-02 4.26e-01 5.25e-02
Common Pathway of Fibrin Clot Formation 14 5.88e-03 4.25e-01 1.99e-02
Budding and maturation of HIV virion 26 1.97e-04 4.22e-01 1.26e-03
Metabolism of non-coding RNA 53 1.39e-07 -4.18e-01 2.26e-06
snRNP Assembly 53 1.39e-07 -4.18e-01 2.26e-06
Transferrin endocytosis and recycling 26 2.32e-04 4.17e-01 1.42e-03
Classical antibody-mediated complement activation 69 2.10e-09 -4.17e-01 5.02e-08
Sealing of the nuclear envelope (NE) by ESCRT-III 25 3.28e-04 4.15e-01 1.90e-03
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 21 1.02e-03 4.14e-01 5.00e-03
Neurodegenerative Diseases 21 1.02e-03 4.14e-01 5.00e-03
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 1.35e-02 4.12e-01 3.87e-02
Diseases of hemostasis 12 1.35e-02 4.12e-01 3.87e-02
ROS and RNS production in phagocytes 31 7.41e-05 4.11e-01 5.72e-04
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 1.37e-02 4.11e-01 3.92e-02
Regulation of signaling by CBL 18 2.63e-03 4.09e-01 1.05e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 1.08e-03 4.03e-01 5.24e-03
Collagen degradation 29 1.78e-04 4.02e-01 1.16e-03
Creation of C4 and C2 activators 71 4.63e-09 -4.02e-01 1.05e-07
Spry regulation of FGF signaling 16 5.42e-03 4.01e-01 1.87e-02
HDMs demethylate histones 22 1.17e-03 4.00e-01 5.64e-03
Signaling by RAF1 mutants 34 5.68e-05 3.99e-01 4.47e-04
Rev-mediated nuclear export of HIV RNA 35 4.47e-05 -3.99e-01 3.65e-04
Translesion synthesis by REV1 16 6.00e-03 -3.97e-01 2.02e-02
G-protein beta:gamma signalling 29 2.24e-04 3.96e-01 1.38e-03
Scavenging of heme from plasma 71 8.50e-09 -3.95e-01 1.78e-07
Signaling by Leptin 10 3.09e-02 3.94e-01 7.62e-02
LDL clearance 18 3.80e-03 3.94e-01 1.42e-02
Pentose phosphate pathway 13 1.41e-02 3.93e-01 4.02e-02
Interactions of Vpr with host cellular proteins 37 3.52e-05 -3.93e-01 3.05e-04
RORA activates gene expression 18 4.09e-03 3.91e-01 1.50e-02
Interactions of Rev with host cellular proteins 37 3.88e-05 -3.91e-01 3.32e-04
Regulated proteolysis of p75NTR 11 2.51e-02 3.90e-01 6.54e-02
Resolution of Abasic Sites (AP sites) 37 4.04e-05 -3.90e-01 3.37e-04
Polymerase switching on the C-strand of the telomere 26 5.95e-04 -3.89e-01 3.21e-03
EPH-Ephrin signaling 79 2.26e-09 3.89e-01 5.31e-08
Vpr-mediated nuclear import of PICs 34 9.33e-05 -3.87e-01 6.94e-04
Integrin signaling 22 1.78e-03 3.85e-01 7.84e-03
Beta-catenin phosphorylation cascade 17 6.05e-03 3.85e-01 2.03e-02
COPI-mediated anterograde transport 78 5.53e-09 3.82e-01 1.21e-07
FCGR activation 76 8.92e-09 -3.81e-01 1.84e-07
VxPx cargo-targeting to cilium 19 4.02e-03 3.81e-01 1.48e-02
InlB-mediated entry of Listeria monocytogenes into host cell 12 2.28e-02 3.80e-01 5.98e-02
Translesion synthesis by POLI 17 6.90e-03 -3.78e-01 2.25e-02
EPHA-mediated growth cone collapse 13 1.82e-02 3.78e-01 4.96e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 1.45e-02 -3.77e-01 4.12e-02
activated TAK1 mediates p38 MAPK activation 19 4.44e-03 3.77e-01 1.60e-02
Post-translational protein phosphorylation 70 5.06e-08 3.77e-01 9.28e-07
Extension of Telomeres 51 3.33e-06 -3.76e-01 3.76e-05
Platelet Aggregation (Plug Formation) 28 6.21e-04 3.74e-01 3.30e-03
Glycogen breakdown (glycogenolysis) 13 1.97e-02 3.74e-01 5.26e-02
NEP/NS2 Interacts with the Cellular Export Machinery 32 2.58e-04 -3.73e-01 1.57e-03
Postmitotic nuclear pore complex (NPC) reformation 27 8.35e-04 -3.71e-01 4.27e-03
Chondroitin sulfate biosynthesis 12 2.66e-02 3.70e-01 6.88e-02
Nuclear import of Rev protein 34 1.91e-04 -3.70e-01 1.22e-03
GAB1 signalosome 15 1.34e-02 3.69e-01 3.87e-02
Beta-oxidation of very long chain fatty acids 10 4.64e-02 3.64e-01 1.04e-01
COPII-mediated vesicle transport 65 4.12e-07 3.63e-01 5.72e-06
Pyrimidine salvage 10 4.71e-02 3.63e-01 1.05e-01
Signal regulatory protein family interactions 12 2.99e-02 3.62e-01 7.45e-02
trans-Golgi Network Vesicle Budding 69 2.09e-07 3.61e-01 3.28e-06
Translation 295 1.47e-26 -3.61e-01 1.05e-24
ER to Golgi Anterograde Transport 129 1.77e-12 3.59e-01 6.52e-11
RAF activation 32 4.59e-04 3.58e-01 2.54e-03
Response to elevated platelet cytosolic Ca2+ 110 8.77e-11 3.58e-01 2.49e-09
tRNA processing in the nucleus 59 2.03e-06 -3.57e-01 2.49e-05
DARPP-32 events 22 3.71e-03 3.57e-01 1.39e-02
Scavenging by Class A Receptors 11 4.02e-02 3.57e-01 9.31e-02
Thrombin signalling through proteinase activated receptors (PARs) 27 1.35e-03 3.56e-01 6.26e-03
Paradoxical activation of RAF signaling by kinase inactive BRAF 38 1.44e-04 3.56e-01 9.58e-04
Signaling by RAS mutants 38 1.44e-04 3.56e-01 9.58e-04
Signaling by moderate kinase activity BRAF mutants 38 1.44e-04 3.56e-01 9.58e-04
Signaling downstream of RAS mutants 38 1.44e-04 3.56e-01 9.58e-04
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 9.65e-05 3.56e-01 7.10e-04
Initial triggering of complement 78 5.50e-08 -3.56e-01 9.85e-07
Platelet degranulation 106 2.54e-10 3.55e-01 6.77e-09
ADP signalling through P2Y purinoceptor 1 21 5.10e-03 3.53e-01 1.79e-02
Signal amplification 28 1.23e-03 3.53e-01 5.83e-03
Apoptosis induced DNA fragmentation 10 5.35e-02 3.53e-01 1.15e-01
RAB geranylgeranylation 60 2.34e-06 3.52e-01 2.82e-05
Processive synthesis on the C-strand of the telomere 19 7.90e-03 -3.52e-01 2.55e-02
mRNA decay by 3' to 5' exoribonuclease 16 1.48e-02 -3.52e-01 4.17e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 25 2.40e-03 -3.51e-01 9.78e-03
RNA Polymerase I Transcription Initiation 47 3.30e-05 -3.50e-01 2.89e-04
DNA methylation 20 6.84e-03 3.49e-01 2.24e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 81 7.62e-08 3.45e-01 1.31e-06
Butyrophilin (BTN) family interactions 10 5.90e-02 -3.45e-01 1.24e-01
Fanconi Anemia Pathway 36 3.52e-04 -3.44e-01 2.02e-03
Translesion synthesis by POLK 17 1.43e-02 -3.43e-01 4.07e-02
Interleukin-6 signaling 10 6.07e-02 3.42e-01 1.27e-01
PKA activation in glucagon signalling 14 2.69e-02 3.42e-01 6.91e-02
Mitochondrial tRNA aminoacylation 21 6.89e-03 -3.41e-01 2.25e-02
RAB GEFs exchange GTP for GDP on RABs 88 3.45e-08 3.40e-01 6.53e-07
ADP signalling through P2Y purinoceptor 12 18 1.29e-02 3.39e-01 3.77e-02
Export of Viral Ribonucleoproteins from Nucleus 33 7.73e-04 -3.38e-01 3.97e-03
Diseases of programmed cell death 23 4.99e-03 3.38e-01 1.77e-02
Lysosome Vesicle Biogenesis 32 9.38e-04 3.38e-01 4.66e-03
Platelet activation, signaling and aggregation 221 4.93e-18 3.38e-01 2.24e-16
SHC1 events in EGFR signaling 12 4.29e-02 3.37e-01 9.75e-02
Clathrin-mediated endocytosis 127 5.36e-11 3.37e-01 1.66e-09
Role of LAT2/NTAL/LAB on calcium mobilization 74 5.43e-07 -3.37e-01 7.47e-06
Golgi Associated Vesicle Biogenesis 55 1.58e-05 3.37e-01 1.50e-04
Growth hormone receptor signaling 20 9.68e-03 3.34e-01 2.95e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 3.91e-03 3.33e-01 1.45e-02
G beta:gamma signalling through PI3Kgamma 22 6.82e-03 3.33e-01 2.24e-02
G beta:gamma signalling through CDC42 17 1.80e-02 3.31e-01 4.92e-02
Adenylate cyclase inhibitory pathway 11 5.72e-02 3.31e-01 1.21e-01
EGFR downregulation 27 2.93e-03 3.31e-01 1.14e-02
Transport of Ribonucleoproteins into the Host Nucleus 32 1.21e-03 -3.30e-01 5.78e-03
Regulation of IFNA signaling 12 4.81e-02 3.29e-01 1.07e-01
Transport of the SLBP independent Mature mRNA 35 7.52e-04 -3.29e-01 3.88e-03
Suppression of phagosomal maturation 12 4.85e-02 3.29e-01 1.07e-01
tRNA processing 134 5.71e-11 -3.28e-01 1.72e-09
RNA Polymerase I Transcription Termination 30 2.03e-03 -3.26e-01 8.71e-03
RHO GTPases activate KTN1 11 6.17e-02 3.25e-01 1.28e-01
Mismatch Repair 15 2.93e-02 -3.25e-01 7.31e-02
Role of phospholipids in phagocytosis 88 1.58e-07 -3.23e-01 2.54e-06
Energy dependent regulation of mTOR by LKB1-AMPK 27 3.70e-03 3.23e-01 1.39e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 3.66e-02 -3.23e-01 8.65e-02
Transport of the SLBP Dependant Mature mRNA 36 8.75e-04 -3.20e-01 4.42e-03
Response of Mtb to phagocytosis 22 9.40e-03 3.20e-01 2.89e-02
tRNA Aminoacylation 42 3.41e-04 -3.19e-01 1.97e-03
Golgi-to-ER retrograde transport 111 6.39e-09 3.19e-01 1.38e-07
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 4.38e-05 3.19e-01 3.61e-04
Transcriptional regulation of granulopoiesis 46 1.90e-04 3.18e-01 1.22e-03
Late endosomal microautophagy 30 2.58e-03 3.18e-01 1.03e-02
Antigen processing-Cross presentation 97 6.27e-08 3.18e-01 1.09e-06
Translation of Replicase and Assembly of the Replication Transcription Complex 12 5.68e-02 3.18e-01 1.21e-01
G beta:gamma signalling through BTK 15 3.35e-02 3.17e-01 8.13e-02
Intraflagellar transport 39 6.27e-04 -3.16e-01 3.32e-03
Post-chaperonin tubulin folding pathway 19 1.74e-02 3.15e-01 4.77e-02
Regulation of expression of SLITs and ROBOs 159 6.84e-12 -3.15e-01 2.27e-10
Amyloid fiber formation 51 9.89e-05 3.15e-01 7.24e-04
Misspliced GSK3beta mutants stabilize beta-catenin 15 3.48e-02 3.15e-01 8.33e-02
S33 mutants of beta-catenin aren't phosphorylated 15 3.48e-02 3.15e-01 8.33e-02
S37 mutants of beta-catenin aren't phosphorylated 15 3.48e-02 3.15e-01 8.33e-02
S45 mutants of beta-catenin aren't phosphorylated 15 3.48e-02 3.15e-01 8.33e-02
T41 mutants of beta-catenin aren't phosphorylated 15 3.48e-02 3.15e-01 8.33e-02
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 3.48e-02 3.15e-01 8.33e-02
Signaling by MET 61 2.13e-05 3.15e-01 1.96e-04
TBC/RABGAPs 45 2.62e-04 3.14e-01 1.58e-03
Gastrin-CREB signalling pathway via PKC and MAPK 14 4.17e-02 3.14e-01 9.54e-02
Cargo recognition for clathrin-mediated endocytosis 90 2.98e-07 3.12e-01 4.22e-06
Signalling to ERKs 32 2.26e-03 3.12e-01 9.39e-03
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 2.43e-07 3.11e-01 3.52e-06
Toll Like Receptor 2 (TLR2) Cascade 92 2.43e-07 3.11e-01 3.52e-06
Toll Like Receptor TLR1:TLR2 Cascade 92 2.43e-07 3.11e-01 3.52e-06
Toll Like Receptor TLR6:TLR2 Cascade 92 2.43e-07 3.11e-01 3.52e-06
Removal of the Flap Intermediate from the C-strand 17 2.65e-02 -3.11e-01 6.88e-02
Synthesis of PC 24 8.52e-03 3.10e-01 2.68e-02
Cellular response to hypoxia 71 6.27e-06 3.10e-01 6.72e-05
Transport to the Golgi and subsequent modification 155 2.81e-11 3.10e-01 8.91e-10
Caspase activation via extrinsic apoptotic signalling pathway 25 7.69e-03 3.08e-01 2.49e-02
Endogenous sterols 17 2.80e-02 3.08e-01 7.06e-02
Termination of translesion DNA synthesis 32 2.60e-03 -3.08e-01 1.04e-02
Glucagon signaling in metabolic regulation 27 5.70e-03 3.07e-01 1.94e-02
FCERI mediated Ca+2 mobilization 89 6.26e-07 -3.06e-01 8.53e-06
Notch-HLH transcription pathway 28 5.16e-03 3.05e-01 1.80e-02
ERK/MAPK targets 22 1.33e-02 3.05e-01 3.86e-02
Interleukin-1 signaling 97 2.25e-07 3.04e-01 3.44e-06
The NLRP3 inflammasome 15 4.14e-02 3.04e-01 9.50e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 48 2.69e-04 3.04e-01 1.61e-03
G beta:gamma signalling through PLC beta 17 3.06e-02 3.03e-01 7.56e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 1.65e-06 -3.02e-01 2.12e-05
Activation of GABAB receptors 30 4.19e-03 3.02e-01 1.53e-02
GABA B receptor activation 30 4.19e-03 3.02e-01 1.53e-02
GABA receptor activation 35 2.00e-03 3.02e-01 8.63e-03
Pre-NOTCH Expression and Processing 65 2.66e-05 3.01e-01 2.36e-04
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 3.22e-03 -3.01e-01 1.23e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 3.22e-03 -3.01e-01 1.23e-02
Glutamate and glutamine metabolism 12 7.11e-02 -3.01e-01 1.40e-01
Packaging Of Telomere Ends 20 1.99e-02 3.01e-01 5.31e-02
Formation of apoptosome 11 8.43e-02 3.01e-01 1.61e-01
Regulation of the apoptosome activity 11 8.43e-02 3.01e-01 1.61e-01
Diseases of DNA repair 10 9.99e-02 -3.00e-01 1.83e-01
Signaling by BRAF and RAF fusions 57 8.93e-05 3.00e-01 6.72e-04
HDR through MMEJ (alt-NHEJ) 10 1.00e-01 -3.00e-01 1.84e-01
Infection with Mycobacterium tuberculosis 26 8.21e-03 2.99e-01 2.61e-02
Semaphorin interactions 57 9.21e-05 2.99e-01 6.88e-04
Cytochrome c-mediated apoptotic response 13 6.18e-02 2.99e-01 1.28e-01
Toll Like Receptor 4 (TLR4) Cascade 121 1.60e-08 2.97e-01 3.16e-07
Activation of gene expression by SREBF (SREBP) 42 8.69e-04 2.97e-01 4.42e-03
Plasma lipoprotein clearance 29 5.70e-03 2.97e-01 1.94e-02
Rab regulation of trafficking 121 1.78e-08 2.96e-01 3.46e-07
Surfactant metabolism 21 1.93e-02 2.95e-01 5.23e-02
Membrane Trafficking 558 1.15e-32 2.94e-01 2.62e-30
FOXO-mediated transcription of cell death genes 16 4.18e-02 2.94e-01 9.56e-02
Degradation of the extracellular matrix 78 7.22e-06 2.94e-01 7.50e-05
NS1 Mediated Effects on Host Pathways 40 1.30e-03 -2.94e-01 6.08e-03
Metabolism of amine-derived hormones 10 1.08e-01 -2.93e-01 1.95e-01
Recognition of DNA damage by PCNA-containing replication complex 30 5.52e-03 -2.93e-01 1.89e-02
MET activates RAS signaling 10 1.09e-01 2.92e-01 1.96e-01
L1CAM interactions 85 3.25e-06 2.92e-01 3.74e-05
Pre-NOTCH Transcription and Translation 49 4.06e-04 2.92e-01 2.30e-03
PPARA activates gene expression 104 2.70e-07 2.92e-01 3.87e-06
GRB2 events in EGFR signaling 11 9.38e-02 2.92e-01 1.76e-01
Plasma lipoprotein remodeling 18 3.22e-02 2.92e-01 7.84e-02
Glycosphingolipid metabolism 36 2.46e-03 2.92e-01 9.97e-03
Platelet Adhesion to exposed collagen 13 6.97e-02 2.91e-01 1.39e-01
Membrane binding and targetting of GAG proteins 13 6.98e-02 2.90e-01 1.39e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 6.98e-02 2.90e-01 1.39e-01
Dectin-2 family 19 2.89e-02 2.90e-01 7.24e-02
Josephin domain DUBs 10 1.13e-01 2.89e-01 2.01e-01
Formation of Fibrin Clot (Clotting Cascade) 26 1.07e-02 2.89e-01 3.22e-02
Innate Immune System 967 4.23e-52 2.88e-01 2.88e-49
Plasma lipoprotein assembly, remodeling, and clearance 53 3.03e-04 2.87e-01 1.78e-03
Cross-presentation of soluble exogenous antigens (endosomes) 47 6.90e-04 2.86e-01 3.60e-03
RNA Polymerase III Chain Elongation 18 3.57e-02 -2.86e-01 8.49e-02
Activation of Matrix Metalloproteinases 23 1.78e-02 2.85e-01 4.88e-02
G-protein activation 23 1.79e-02 2.85e-01 4.90e-02
Activation of G protein gated Potassium channels 19 3.16e-02 2.85e-01 7.72e-02
G protein gated Potassium channels 19 3.16e-02 2.85e-01 7.72e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 3.16e-02 2.85e-01 7.72e-02
Oncogenic MAPK signaling 73 2.65e-05 2.84e-01 2.36e-04
ER-Phagosome pathway 82 8.64e-06 2.84e-01 8.84e-05
Activated NOTCH1 Transmits Signal to the Nucleus 27 1.09e-02 2.83e-01 3.25e-02
Triglyceride catabolism 16 5.00e-02 2.83e-01 1.10e-01
Mitochondrial translation elongation 91 3.35e-06 -2.82e-01 3.76e-05
Plasma lipoprotein assembly 10 1.23e-01 2.82e-01 2.15e-01
MET promotes cell motility 26 1.31e-02 2.81e-01 3.81e-02
Assembly Of The HIV Virion 15 5.97e-02 2.81e-01 1.25e-01
Toll-like Receptor Cascades 143 6.68e-09 2.81e-01 1.42e-07
Biotin transport and metabolism 11 1.07e-01 -2.81e-01 1.93e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.02e-02 -2.80e-01 3.08e-02
EPH-ephrin mediated repulsion of cells 40 2.19e-03 2.80e-01 9.13e-03
AMER1 mutants destabilize the destruction complex 14 6.99e-02 2.80e-01 1.39e-01
APC truncation mutants have impaired AXIN binding 14 6.99e-02 2.80e-01 1.39e-01
AXIN missense mutants destabilize the destruction complex 14 6.99e-02 2.80e-01 1.39e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 6.99e-02 2.80e-01 1.39e-01
Truncations of AMER1 destabilize the destruction complex 14 6.99e-02 2.80e-01 1.39e-01
truncated APC mutants destabilize the destruction complex 14 6.99e-02 2.80e-01 1.39e-01
Metabolism of steroid hormones 20 3.04e-02 2.80e-01 7.53e-02
Regulation of lipid metabolism by PPARalpha 106 6.88e-07 2.79e-01 9.28e-06
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 1.14e-04 2.79e-01 8.05e-04
Signaling by NTRKs 116 2.43e-07 2.77e-01 3.52e-06
SUMOylation of immune response proteins 11 1.11e-01 2.77e-01 1.99e-01
Homologous DNA Pairing and Strand Exchange 42 1.87e-03 -2.77e-01 8.16e-03
Assembly of active LPL and LIPC lipase complexes 10 1.29e-01 2.77e-01 2.23e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 1.30e-01 2.76e-01 2.24e-01
Interleukin-1 family signaling 124 1.23e-07 2.75e-01 2.04e-06
SUMOylation of SUMOylation proteins 35 4.94e-03 -2.75e-01 1.76e-02
Calnexin/calreticulin cycle 26 1.55e-02 2.74e-01 4.35e-02
Early Phase of HIV Life Cycle 14 7.61e-02 -2.74e-01 1.48e-01
Regulation of ornithine decarboxylase (ODC) 49 9.46e-04 2.73e-01 4.68e-03
HSP90 chaperone cycle for steroid hormone receptors (SHR) 36 4.72e-03 2.72e-01 1.69e-02
Signaling by NTRK1 (TRKA) 101 2.36e-06 2.72e-01 2.82e-05
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 88 1.05e-05 2.72e-01 1.04e-04
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 6.90e-02 2.71e-01 1.39e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 53 6.41e-04 2.71e-01 3.38e-03
MyD88 dependent cascade initiated on endosome 89 1.00e-05 2.71e-01 1.00e-04
Toll Like Receptor 7/8 (TLR7/8) Cascade 89 1.00e-05 2.71e-01 1.00e-04
ABC transporters in lipid homeostasis 14 7.96e-02 -2.71e-01 1.53e-01
Cytosolic tRNA aminoacylation 24 2.19e-02 -2.70e-01 5.81e-02
Negative regulation of FGFR1 signaling 24 2.23e-02 2.69e-01 5.89e-02
Signaling by NOTCH4 78 4.01e-05 2.69e-01 3.37e-04
Platelet homeostasis 69 1.15e-04 2.68e-01 8.05e-04
Dual Incision in GG-NER 41 2.95e-03 -2.68e-01 1.15e-02
Mitochondrial translation termination 91 1.01e-05 -2.68e-01 1.01e-04
Hedgehog ligand biogenesis 58 4.24e-04 2.68e-01 2.40e-03
Transport of Mature mRNA Derived from an Intronless Transcript 42 2.70e-03 -2.67e-01 1.07e-02
Presynaptic phase of homologous DNA pairing and strand exchange 39 3.87e-03 -2.67e-01 1.44e-02
Glycogen metabolism 23 2.67e-02 2.67e-01 6.91e-02
Defective CFTR causes cystic fibrosis 59 3.96e-04 2.67e-01 2.26e-03
Regulation of PTEN stability and activity 66 1.84e-04 2.66e-01 1.20e-03
Cell-extracellular matrix interactions 14 8.50e-02 2.66e-01 1.62e-01
Metabolism of porphyrins 22 3.10e-02 2.66e-01 7.62e-02
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 6.61e-02 2.65e-01 1.35e-01
Mitochondrial translation initiation 91 1.22e-05 -2.65e-01 1.18e-04
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 2.77e-02 2.65e-01 7.00e-02
NOTCH3 Intracellular Domain Regulates Transcription 20 4.02e-02 2.65e-01 9.31e-02
Thromboxane signalling through TP receptor 20 4.04e-02 2.65e-01 9.32e-02
Integration of energy metabolism 86 2.19e-05 2.65e-01 2.00e-04
Nucleotide salvage 21 3.58e-02 2.65e-01 8.51e-02
TNFs bind their physiological receptors 25 2.21e-02 -2.64e-01 5.86e-02
VEGFA-VEGFR2 Pathway 92 1.17e-05 2.64e-01 1.15e-04
Signaling by SCF-KIT 40 3.84e-03 2.64e-01 1.43e-02
Amino acids regulate mTORC1 50 1.26e-03 2.64e-01 5.90e-03
Opioid Signalling 75 8.65e-05 2.62e-01 6.54e-04
Aquaporin-mediated transport 37 5.85e-03 2.62e-01 1.98e-02
Glycogen synthesis 13 1.02e-01 2.62e-01 1.86e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 2.98e-03 -2.62e-01 1.16e-02
Diseases associated with glycosylation precursor biosynthesis 18 5.54e-02 2.61e-01 1.19e-01
SUMOylation of RNA binding proteins 47 1.99e-03 -2.61e-01 8.62e-03
IKK complex recruitment mediated by RIP1 23 3.06e-02 2.60e-01 7.56e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 1.95e-02 -2.60e-01 5.24e-02
Mitochondrial translation 97 9.81e-06 -2.60e-01 9.97e-05
Intrinsic Pathway of Fibrin Clot Formation 16 7.34e-02 2.59e-01 1.44e-01
HDACs deacetylate histones 47 2.19e-03 2.58e-01 9.13e-03
Diseases of carbohydrate metabolism 29 1.64e-02 2.58e-01 4.56e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.23e-01 2.57e-01 2.15e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 2.06e-03 2.57e-01 8.80e-03
Binding and Uptake of Ligands by Scavenger Receptors 92 2.08e-05 -2.57e-01 1.95e-04
XBP1(S) activates chaperone genes 47 2.45e-03 2.55e-01 9.96e-03
Toll Like Receptor 9 (TLR9) Cascade 93 2.09e-05 2.55e-01 1.95e-04
Long-term potentiation 14 9.97e-02 -2.54e-01 1.83e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 1.64e-01 2.54e-01 2.71e-01
Hh mutants abrogate ligand secretion 54 1.25e-03 2.54e-01 5.89e-03
Metabolism of RNA 685 9.58e-30 -2.54e-01 1.09e-27
RUNX3 regulates NOTCH signaling 14 1.00e-01 2.54e-01 1.84e-01
FCGR3A-mediated IL10 synthesis 99 1.35e-05 -2.53e-01 1.29e-04
RUNX1 regulates transcription of genes involved in differentiation of HSCs 82 7.44e-05 2.53e-01 5.72e-04
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 2.20e-04 -2.52e-01 1.36e-03
Potential therapeutics for SARS 36 9.00e-03 2.52e-01 2.80e-02
Citric acid cycle (TCA cycle) 22 4.14e-02 2.51e-01 9.50e-02
Bile acid and bile salt metabolism 29 1.94e-02 2.51e-01 5.23e-02
Presynaptic function of Kainate receptors 18 6.54e-02 2.51e-01 1.34e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 1.15e-02 2.50e-01 3.42e-02
Interleukin-15 signaling 14 1.05e-01 2.50e-01 1.90e-01
Nuclear Pore Complex (NPC) Disassembly 36 9.46e-03 -2.50e-01 2.90e-02
G alpha (z) signalling events 36 9.60e-03 2.49e-01 2.93e-02
Gluconeogenesis 28 2.26e-02 2.49e-01 5.94e-02
GP1b-IX-V activation signalling 10 1.73e-01 2.49e-01 2.81e-01
Folding of actin by CCT/TriC 10 1.74e-01 -2.48e-01 2.82e-01
Initiation of Nuclear Envelope (NE) Reformation 19 6.12e-02 2.48e-01 1.27e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 4.40e-02 2.48e-01 9.89e-02
Signaling by NOTCH3 42 5.44e-03 2.48e-01 1.87e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 179 1.08e-08 2.48e-01 2.19e-07
MyD88 cascade initiated on plasma membrane 82 1.07e-04 2.47e-01 7.70e-04
Toll Like Receptor 10 (TLR10) Cascade 82 1.07e-04 2.47e-01 7.70e-04
Toll Like Receptor 5 (TLR5) Cascade 82 1.07e-04 2.47e-01 7.70e-04
Translesion Synthesis by POLH 18 7.01e-02 -2.47e-01 1.39e-01
Sphingolipid metabolism 77 1.91e-04 2.46e-01 1.22e-03
Negative regulation of NOTCH4 signaling 54 1.86e-03 2.45e-01 8.12e-03
Signaling by NOTCH 182 1.21e-08 2.45e-01 2.43e-07
Retinoid metabolism and transport 24 3.82e-02 2.44e-01 8.96e-02
Activation of BAD and translocation to mitochondria 15 1.01e-01 2.44e-01 1.85e-01
IRE1alpha activates chaperones 49 3.09e-03 2.44e-01 1.19e-02
Adherens junctions interactions 18 7.28e-02 2.44e-01 1.43e-01
Transcriptional Regulation by E2F6 34 1.39e-02 -2.44e-01 3.98e-02
Negative regulation of FGFR3 signaling 20 6.02e-02 2.43e-01 1.26e-01
Vif-mediated degradation of APOBEC3G 52 2.50e-03 2.42e-01 1.01e-02
Transcriptional regulation of white adipocyte differentiation 77 2.42e-04 2.42e-01 1.48e-03
Degradation of DVL 54 2.12e-03 2.42e-01 8.98e-03
MTOR signalling 38 1.03e-02 2.40e-01 3.10e-02
RHO GTPase Effectors 250 5.80e-11 2.40e-01 1.72e-09
Regulation of Complement cascade 95 5.13e-05 -2.40e-01 4.13e-04
Defects in vitamin and cofactor metabolism 21 5.66e-02 -2.40e-01 1.21e-01
Interleukin-10 signaling 34 1.53e-02 2.40e-01 4.31e-02
Iron uptake and transport 52 2.73e-03 2.40e-01 1.08e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 1.88e-02 2.40e-01 5.11e-02
Acyl chain remodelling of PC 19 7.06e-02 2.40e-01 1.40e-01
Signaling by Hippo 18 7.92e-02 2.39e-01 1.53e-01
PCP/CE pathway 86 1.32e-04 2.38e-01 8.99e-04
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 1.23e-01 2.38e-01 2.15e-01
MyD88-independent TLR4 cascade 96 5.53e-05 2.38e-01 4.38e-04
TRIF(TICAM1)-mediated TLR4 signaling 96 5.53e-05 2.38e-01 4.38e-04
FCERI mediated MAPK activation 90 9.50e-05 -2.38e-01 7.03e-04
Metabolism of steroids 119 7.36e-06 2.38e-01 7.59e-05
Listeria monocytogenes entry into host cells 17 8.98e-02 2.38e-01 1.70e-01
Signaling by VEGF 100 4.06e-05 2.37e-01 3.37e-04
Asparagine N-linked glycosylation 269 2.05e-11 2.37e-01 6.64e-10
Complement cascade 99 4.51e-05 -2.37e-01 3.65e-04
Signaling by cytosolic FGFR1 fusion mutants 18 8.16e-02 2.37e-01 1.56e-01
Carboxyterminal post-translational modifications of tubulin 26 3.67e-02 2.37e-01 8.68e-02
Apoptotic execution phase 45 6.17e-03 2.36e-01 2.07e-02
COPI-dependent Golgi-to-ER retrograde traffic 78 3.17e-04 2.36e-01 1.84e-03
Assembly and cell surface presentation of NMDA receptors 18 8.35e-02 -2.36e-01 1.60e-01
Acyl chain remodelling of PI 10 1.98e-01 2.35e-01 3.11e-01
SARS-CoV Infections 83 2.16e-04 2.35e-01 1.36e-03
Prostacyclin signalling through prostacyclin receptor 16 1.04e-01 2.35e-01 1.88e-01
ATF6 (ATF6-alpha) activates chaperones 12 1.60e-01 2.35e-01 2.65e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 3.49e-03 2.34e-01 1.32e-02
Cleavage of the damaged purine 24 4.71e-02 2.34e-01 1.05e-01
Depurination 24 4.71e-02 2.34e-01 1.05e-01
Recognition and association of DNA glycosylase with site containing an affected purine 24 4.71e-02 2.34e-01 1.05e-01
SUMOylation of chromatin organization proteins 57 2.30e-03 -2.33e-01 9.47e-03
RUNX3 regulates p14-ARF 10 2.02e-01 2.33e-01 3.15e-01
Nuclear Events (kinase and transcription factor activation) 53 3.37e-03 2.33e-01 1.29e-02
Regulation of FZD by ubiquitination 15 1.20e-01 -2.32e-01 2.11e-01
Regulation of Apoptosis 51 4.23e-03 2.32e-01 1.54e-02
Degradation of GLI1 by the proteasome 57 2.57e-03 2.31e-01 1.03e-02
MAP kinase activation 63 1.54e-03 2.31e-01 6.91e-03
Signaling by EGFR 46 6.79e-03 2.31e-01 2.24e-02
PKA activation 15 1.22e-01 2.30e-01 2.15e-01
DAP12 interactions 39 1.29e-02 2.30e-01 3.77e-02
PLC beta mediated events 43 9.33e-03 2.29e-01 2.87e-02
NOTCH2 intracellular domain regulates transcription 11 1.91e-01 2.28e-01 3.03e-01
Intra-Golgi traffic 43 9.82e-03 2.28e-01 2.98e-02
HDR through Single Strand Annealing (SSA) 37 1.67e-02 -2.27e-01 4.62e-02
Interleukin-27 signaling 11 1.93e-01 2.27e-01 3.05e-01
Cytosolic iron-sulfur cluster assembly 13 1.57e-01 -2.27e-01 2.62e-01
mTORC1-mediated signalling 23 6.05e-02 2.26e-01 1.26e-01
Degradation of GLI2 by the proteasome 56 3.44e-03 2.26e-01 1.31e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 2.47e-02 2.26e-01 6.45e-02
Tie2 Signaling 16 1.18e-01 2.26e-01 2.08e-01
Signaling by FGFR1 38 1.62e-02 2.25e-01 4.51e-02
SUMOylation of intracellular receptors 25 5.11e-02 2.25e-01 1.12e-01
RET signaling 32 2.77e-02 2.25e-01 7.00e-02
Defects in cobalamin (B12) metabolism 13 1.61e-01 -2.25e-01 2.66e-01
ER Quality Control Compartment (ERQC) 21 7.48e-02 2.25e-01 1.46e-01
G-protein mediated events 44 9.96e-03 2.25e-01 3.01e-02
NOTCH4 Intracellular Domain Regulates Transcription 17 1.09e-01 2.24e-01 1.96e-01
Signaling by Receptor Tyrosine Kinases 414 4.77e-15 2.24e-01 1.97e-13
Metalloprotease DUBs 21 7.53e-02 2.24e-01 1.47e-01
HDR through Homologous Recombination (HRR) 66 1.66e-03 -2.24e-01 7.40e-03
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 3.70e-02 2.24e-01 8.73e-02
G1/S-Specific Transcription 29 3.73e-02 -2.23e-01 8.77e-02
Regulation of RUNX3 expression and activity 55 4.15e-03 2.23e-01 1.52e-02
Signaling by Insulin receptor 59 2.99e-03 2.23e-01 1.16e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 5.00e-03 2.23e-01 1.77e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.25e-02 2.23e-01 5.94e-02
Signaling by ROBO receptors 199 5.96e-08 -2.23e-01 1.05e-06
Regulation of insulin secretion 60 2.90e-03 2.22e-01 1.14e-02
Transport of bile salts and organic acids, metal ions and amine compounds 55 4.36e-03 2.22e-01 1.58e-02
FGFR1 mutant receptor activation 24 5.97e-02 2.22e-01 1.25e-01
Mitochondrial protein import 64 2.14e-03 -2.22e-01 9.02e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.66e-01 2.22e-01 2.73e-01
SARS-CoV-1 Infection 47 8.67e-03 2.21e-01 2.71e-02
Inflammasomes 20 8.85e-02 2.20e-01 1.67e-01
Viral Messenger RNA Synthesis 44 1.17e-02 -2.20e-01 3.47e-02
Synthesis of PIPs at the plasma membrane 52 6.24e-03 2.19e-01 2.08e-02
Interleukin receptor SHC signaling 23 6.89e-02 2.19e-01 1.39e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 1.21e-01 -2.17e-01 2.12e-01
Transport of Mature Transcript to Cytoplasm 81 7.27e-04 -2.17e-01 3.76e-03
Tight junction interactions 18 1.12e-01 -2.16e-01 2.00e-01
Transcriptional regulation of pluripotent stem cells 19 1.03e-01 2.16e-01 1.87e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 8.18e-03 2.16e-01 2.60e-02
p53-Independent DNA Damage Response 50 8.18e-03 2.16e-01 2.60e-02
p53-Independent G1/S DNA damage checkpoint 50 8.18e-03 2.16e-01 2.60e-02
Myogenesis 21 8.76e-02 2.15e-01 1.66e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 3.81e-02 2.15e-01 8.96e-02
Vesicle-mediated transport 648 1.03e-20 2.15e-01 4.99e-19
Ubiquitin-dependent degradation of Cyclin D 50 8.70e-03 2.14e-01 2.71e-02
Signaling by PDGFRA extracellular domain mutants 12 1.98e-01 2.14e-01 3.11e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 1.98e-01 2.14e-01 3.11e-01
Caspase activation via Death Receptors in the presence of ligand 16 1.38e-01 2.14e-01 2.35e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 9.81e-02 2.14e-01 1.81e-01
Trafficking of AMPA receptors 20 9.81e-02 2.14e-01 1.81e-01
Interleukin-17 signaling 68 2.39e-03 2.13e-01 9.75e-03
ABC transporter disorders 70 2.10e-03 2.13e-01 8.90e-03
Biosynthesis of specialized proresolving mediators (SPMs) 16 1.42e-01 2.12e-01 2.40e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 58 5.18e-03 2.12e-01 1.80e-02
Costimulation by the CD28 family 74 1.61e-03 -2.12e-01 7.21e-03
Programmed Cell Death 169 1.98e-06 2.12e-01 2.45e-05
Uptake and actions of bacterial toxins 27 5.66e-02 2.12e-01 1.21e-01
Signaling by Rho GTPases 367 3.71e-12 2.11e-01 1.29e-10
Apoptosis 166 2.70e-06 2.11e-01 3.19e-05
Rap1 signalling 13 1.88e-01 2.11e-01 2.99e-01
Formation of the cornified envelope 21 9.50e-02 2.10e-01 1.78e-01
Transcription of E2F targets under negative control by DREAM complex 19 1.13e-01 -2.10e-01 2.01e-01
Signaling by Interleukins 385 1.49e-12 2.10e-01 5.63e-11
Ca-dependent events 29 5.04e-02 2.10e-01 1.10e-01
Sialic acid metabolism 28 5.53e-02 2.09e-01 1.19e-01
GLI3 is processed to GLI3R by the proteasome 57 6.45e-03 2.09e-01 2.14e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 1.94e-01 2.08e-01 3.06e-01
Oncogene Induced Senescence 33 3.86e-02 2.08e-01 9.03e-02
MHC class II antigen presentation 101 3.15e-04 2.07e-01 1.84e-03
Ras activation upon Ca2+ influx through NMDA receptor 15 1.65e-01 -2.07e-01 2.72e-01
CD28 dependent PI3K/Akt signaling 22 9.28e-02 -2.07e-01 1.74e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 7.32e-02 2.07e-01 1.44e-01
Metabolism of fat-soluble vitamins 28 5.82e-02 2.07e-01 1.23e-01
Signaling by FGFR3 31 4.69e-02 2.06e-01 1.05e-01
RIP-mediated NFkB activation via ZBP1 17 1.42e-01 2.06e-01 2.40e-01
Hedgehog 'on' state 75 2.10e-03 2.05e-01 8.90e-03
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 27 6.49e-02 2.05e-01 1.33e-01
Sphingolipid de novo biosynthesis 41 2.31e-02 2.05e-01 6.07e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 1.44e-01 2.05e-01 2.43e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 1.13e-01 -2.05e-01 2.01e-01
ZBP1(DAI) mediated induction of type I IFNs 20 1.14e-01 2.04e-01 2.02e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 53 1.02e-02 2.04e-01 3.08e-02
SUMOylation of DNA damage response and repair proteins 77 1.98e-03 -2.04e-01 8.58e-03
SUMOylation of ubiquitinylation proteins 39 2.77e-02 -2.04e-01 7.00e-02
Regulation of TP53 Activity through Methylation 19 1.25e-01 -2.03e-01 2.17e-01
Constitutive Signaling by Overexpressed ERBB2 11 2.43e-01 2.03e-01 3.66e-01
Condensation of Prophase Chromosomes 29 5.91e-02 2.02e-01 1.24e-01
Interleukin-37 signaling 19 1.27e-01 2.02e-01 2.20e-01
Negative regulation of FGFR4 signaling 21 1.09e-01 2.02e-01 1.96e-01
Regulation of localization of FOXO transcription factors 11 2.47e-01 2.02e-01 3.70e-01
Toll Like Receptor 3 (TLR3) Cascade 92 8.80e-04 2.01e-01 4.43e-03
TRAF6 mediated NF-kB activation 23 9.73e-02 2.00e-01 1.80e-01
Autophagy 124 1.24e-04 2.00e-01 8.50e-04
Metabolism of polyamines 57 9.32e-03 1.99e-01 2.87e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 1.68e-01 1.99e-01 2.75e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 1.61e-02 1.99e-01 4.50e-02
Vpu mediated degradation of CD4 50 1.52e-02 1.98e-01 4.29e-02
Signaling by NOTCH1 66 5.36e-03 1.98e-01 1.86e-02
Processing of Capped Intronless Pre-mRNA 28 6.96e-02 -1.98e-01 1.39e-01
Inwardly rectifying K+ channels 23 1.00e-01 1.98e-01 1.83e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 3.46e-02 -1.98e-01 8.33e-02
Degradation of AXIN 53 1.27e-02 1.98e-01 3.73e-02
Glycogen storage diseases 13 2.17e-01 1.98e-01 3.37e-01
Arachidonic acid metabolism 43 2.52e-02 1.97e-01 6.54e-02
O-linked glycosylation of mucins 47 1.93e-02 1.97e-01 5.23e-02
Condensation of Prometaphase Chromosomes 11 2.58e-01 1.97e-01 3.84e-01
Glycerophospholipid biosynthesis 107 4.37e-04 1.97e-01 2.45e-03
Downstream signal transduction 27 7.70e-02 1.97e-01 1.50e-01
Synthesis of bile acids and bile salts 24 9.58e-02 1.96e-01 1.79e-01
Apoptotic cleavage of cellular proteins 34 4.85e-02 1.96e-01 1.07e-01
Peroxisomal lipid metabolism 27 7.89e-02 1.95e-01 1.53e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 2.07e-01 1.95e-01 3.23e-01
Trafficking and processing of endosomal TLR 13 2.24e-01 1.95e-01 3.44e-01
Apoptotic factor-mediated response 18 1.54e-01 1.94e-01 2.57e-01
Activation of NF-kappaB in B cells 65 6.77e-03 1.94e-01 2.24e-02
NR1H2 and NR1H3-mediated signaling 39 3.63e-02 1.94e-01 8.61e-02
NIK-->noncanonical NF-kB signaling 57 1.15e-02 1.94e-01 3.40e-02
RUNX2 regulates bone development 23 1.08e-01 1.94e-01 1.95e-01
Metabolism of lipids 625 2.32e-16 1.92e-01 1.02e-14
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.85e-01 1.91e-01 2.96e-01
Beta-catenin independent WNT signaling 136 1.20e-04 1.91e-01 8.30e-04
Phospholipid metabolism 186 7.15e-06 1.91e-01 7.49e-05
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 1.88e-01 -1.90e-01 2.99e-01
Regulation of RAS by GAPs 66 7.53e-03 1.90e-01 2.45e-02
Glycosaminoglycan metabolism 94 1.52e-03 1.89e-01 6.87e-03
A tetrasaccharide linker sequence is required for GAG synthesis 17 1.77e-01 -1.89e-01 2.85e-01
Constitutive Signaling by EGFRvIII 14 2.22e-01 1.89e-01 3.43e-01
Signaling by EGFRvIII in Cancer 14 2.22e-01 1.89e-01 3.43e-01
Dectin-1 mediated noncanonical NF-kB signaling 58 1.33e-02 1.88e-01 3.86e-02
CLEC7A (Dectin-1) signaling 96 1.46e-03 1.88e-01 6.65e-03
Collagen formation 66 8.30e-03 1.88e-01 2.62e-02
Carnitine metabolism 10 3.04e-01 1.88e-01 4.34e-01
Rho GTPase cycle 126 2.76e-04 1.88e-01 1.65e-03
cGMP effects 13 2.42e-01 1.87e-01 3.66e-01
Diseases of signal transduction by growth factor receptors and second messengers 340 2.93e-09 1.87e-01 6.76e-08
E3 ubiquitin ligases ubiquitinate target proteins 52 1.97e-02 1.87e-01 5.26e-02
Formation of ATP by chemiosmotic coupling 18 1.70e-01 1.87e-01 2.77e-01
Ion channel transport 133 1.98e-04 1.87e-01 1.26e-03
Cell recruitment (pro-inflammatory response) 22 1.31e-01 1.86e-01 2.25e-01
Purinergic signaling in leishmaniasis infection 22 1.31e-01 1.86e-01 2.25e-01
Synthesis of PIPs at the late endosome membrane 11 2.85e-01 1.86e-01 4.14e-01
Platelet calcium homeostasis 21 1.40e-01 1.86e-01 2.38e-01
Tryptophan catabolism 12 2.65e-01 1.86e-01 3.92e-01
UCH proteinases 86 2.87e-03 1.86e-01 1.13e-02
C-type lectin receptors (CLRs) 128 2.92e-04 1.85e-01 1.72e-03
Degradation of beta-catenin by the destruction complex 83 3.55e-03 1.85e-01 1.34e-02
rRNA processing in the mitochondrion 27 9.66e-02 -1.85e-01 1.79e-01
E2F mediated regulation of DNA replication 22 1.34e-01 -1.85e-01 2.29e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 8.06e-02 1.84e-01 1.55e-01
Transcriptional regulation by RUNX2 101 1.40e-03 1.84e-01 6.44e-03
DNA Damage Bypass 47 2.93e-02 -1.84e-01 7.31e-02
Senescence-Associated Secretory Phenotype (SASP) 66 9.86e-03 1.84e-01 2.99e-02
RNA Polymerase III Transcription Initiation 36 5.70e-02 -1.83e-01 1.21e-01
Chromosome Maintenance 105 1.18e-03 -1.83e-01 5.66e-03
SHC1 events in ERBB2 signaling 17 1.91e-01 1.83e-01 3.03e-01
Interleukin-2 family signaling 38 5.13e-02 1.83e-01 1.12e-01
Regulation of TP53 Activity through Association with Co-factors 11 2.95e-01 -1.83e-01 4.26e-01
Inhibition of DNA recombination at telomere 35 6.22e-02 1.82e-01 1.28e-01
Acyl chain remodelling of PG 11 3.00e-01 1.81e-01 4.30e-01
TRAF6 mediated IRF7 activation 15 2.26e-01 1.80e-01 3.46e-01
RNA Polymerase II Transcription Termination 65 1.21e-02 -1.80e-01 3.54e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 51 2.71e-02 1.79e-01 6.94e-02
Asymmetric localization of PCP proteins 60 1.67e-02 1.79e-01 4.62e-02
Stabilization of p53 54 2.33e-02 1.78e-01 6.10e-02
Acetylcholine Neurotransmitter Release Cycle 11 3.06e-01 -1.78e-01 4.36e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 1.03e-01 -1.78e-01 1.87e-01
Oxidative Stress Induced Senescence 79 6.20e-03 1.78e-01 2.07e-02
p38MAPK events 13 2.67e-01 1.78e-01 3.95e-01
MASTL Facilitates Mitotic Progression 10 3.31e-01 1.78e-01 4.65e-01
Protein ubiquitination 72 9.26e-03 1.77e-01 2.86e-02
Triglyceride metabolism 25 1.25e-01 1.77e-01 2.17e-01
Chaperonin-mediated protein folding 84 5.06e-03 1.77e-01 1.78e-02
Regulation of TP53 Activity through Acetylation 29 9.92e-02 -1.77e-01 1.82e-01
Activation of the AP-1 family of transcription factors 10 3.34e-01 1.76e-01 4.68e-01
G alpha (12/13) signalling events 69 1.15e-02 1.76e-01 3.40e-02
G0 and Early G1 27 1.14e-01 -1.76e-01 2.01e-01
SCF-beta-TrCP mediated degradation of Emi1 53 2.70e-02 1.76e-01 6.94e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 182 4.49e-05 -1.75e-01 3.65e-04
Cholesterol biosynthesis 24 1.38e-01 1.75e-01 2.35e-01
Insulin processing 21 1.65e-01 1.75e-01 2.72e-01
Negative regulation of MAPK pathway 42 5.04e-02 1.74e-01 1.10e-01
Signaling by WNT in cancer 30 9.82e-02 1.74e-01 1.81e-01
Synaptic adhesion-like molecules 14 2.60e-01 1.74e-01 3.87e-01
Hemostasis 548 3.56e-12 1.74e-01 1.28e-10
Antimicrobial peptides 33 8.51e-02 1.73e-01 1.62e-01
Interleukin-4 and Interleukin-13 signaling 92 4.10e-03 1.73e-01 1.51e-02
Transcriptional regulation by RUNX3 90 4.54e-03 1.73e-01 1.63e-02
Disorders of developmental biology 12 3.00e-01 1.73e-01 4.30e-01
Loss of function of MECP2 in Rett syndrome 12 3.00e-01 1.73e-01 4.30e-01
Pervasive developmental disorders 12 3.00e-01 1.73e-01 4.30e-01
Metabolic disorders of biological oxidation enzymes 25 1.35e-01 1.73e-01 2.30e-01
SUMOylation of DNA replication proteins 46 4.27e-02 -1.73e-01 9.71e-02
PI Metabolism 80 7.73e-03 1.72e-01 2.50e-02
Processing of Capped Intron-Containing Pre-mRNA 238 4.74e-06 -1.72e-01 5.24e-05
RNA Polymerase III Transcription Termination 23 1.54e-01 -1.72e-01 2.57e-01
Protein folding 90 4.86e-03 1.72e-01 1.74e-02
The role of Nef in HIV-1 replication and disease pathogenesis 28 1.17e-01 1.71e-01 2.07e-01
Signaling by WNT 253 3.03e-06 1.70e-01 3.52e-05
Elastic fibre formation 32 9.58e-02 1.70e-01 1.79e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 7.86e-02 1.69e-01 1.52e-01
PECAM1 interactions 12 3.11e-01 1.69e-01 4.42e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 3.12e-01 -1.69e-01 4.42e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 1.34e-02 1.69e-01 3.87e-02
Peroxisomal protein import 57 2.78e-02 1.68e-01 7.00e-02
Regulation of HSF1-mediated heat shock response 79 9.62e-03 -1.68e-01 2.94e-02
NCAM1 interactions 23 1.62e-01 -1.68e-01 2.68e-01
Macroautophagy 110 2.28e-03 1.68e-01 9.41e-03
MAPK6/MAPK4 signaling 82 8.55e-03 1.68e-01 2.68e-02
Gap-filling DNA repair synthesis and ligation in TC-NER 64 2.03e-02 -1.68e-01 5.41e-02
Olfactory Signaling Pathway 58 2.72e-02 1.68e-01 6.95e-02
SUMOylation of DNA methylation proteins 16 2.46e-01 -1.68e-01 3.70e-01
TGF-beta receptor signaling activates SMADs 32 1.01e-01 1.67e-01 1.84e-01
Metabolism of amino acids and derivatives 324 2.18e-07 -1.67e-01 3.37e-06
Muscle contraction 141 6.21e-04 1.67e-01 3.30e-03
Metabolism of Angiotensinogen to Angiotensins 11 3.39e-01 1.67e-01 4.72e-01
Keratan sulfate/keratin metabolism 27 1.35e-01 1.66e-01 2.31e-01
Chemokine receptors bind chemokines 37 8.08e-02 -1.66e-01 1.55e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 3.01e-01 1.66e-01 4.31e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 1.52e-01 1.65e-01 2.56e-01
mRNA Splicing - Minor Pathway 52 4.01e-02 -1.65e-01 9.31e-02
Cleavage of the damaged pyrimidine 29 1.27e-01 1.64e-01 2.20e-01
Depyrimidination 29 1.27e-01 1.64e-01 2.20e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 1.27e-01 1.64e-01 2.20e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 2.17e-01 1.64e-01 3.36e-01
Signaling by EGFR in Cancer 23 1.74e-01 1.64e-01 2.82e-01
Immune System 1893 3.95e-32 1.64e-01 7.69e-30
Extracellular matrix organization 219 3.13e-05 1.63e-01 2.77e-04
Neurotransmitter receptors and postsynaptic signal transmission 123 1.91e-03 1.62e-01 8.31e-03
Deadenylation-dependent mRNA decay 53 4.15e-02 -1.62e-01 9.50e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 87 9.10e-03 1.62e-01 2.83e-02
Telomere Extension By Telomerase 23 1.80e-01 -1.62e-01 2.88e-01
Factors involved in megakaryocyte development and platelet production 116 2.64e-03 1.62e-01 1.05e-02
Effects of PIP2 hydrolysis 24 1.71e-01 -1.62e-01 2.78e-01
Signaling by Non-Receptor Tyrosine Kinases 48 5.30e-02 1.61e-01 1.15e-01
Signaling by PTK6 48 5.30e-02 1.61e-01 1.15e-01
Signaling by FGFR4 31 1.20e-01 1.61e-01 2.11e-01
PINK1-PRKN Mediated Mitophagy 21 2.01e-01 -1.61e-01 3.15e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 4.34e-02 1.60e-01 9.78e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 4.34e-02 1.60e-01 9.78e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 4.34e-02 1.60e-01 9.78e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 4.34e-02 1.60e-01 9.78e-02
Signaling by NOTCH1 in Cancer 53 4.34e-02 1.60e-01 9.78e-02
Receptor Mediated Mitophagy 11 3.58e-01 1.60e-01 4.90e-01
Regulation of KIT signaling 15 2.84e-01 1.60e-01 4.13e-01
Cellular response to heat stress 93 8.06e-03 -1.59e-01 2.58e-02
Inactivation of APC/C via direct inhibition of the APC/C complex 21 2.08e-01 -1.59e-01 3.23e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 2.08e-01 -1.59e-01 3.23e-01
Synthesis of IP3 and IP4 in the cytosol 22 1.97e-01 1.59e-01 3.11e-01
DNA Damage/Telomere Stress Induced Senescence 44 6.89e-02 1.59e-01 1.39e-01
Dual incision in TC-NER 65 2.75e-02 -1.58e-01 6.99e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 2.46e-01 1.58e-01 3.70e-01
Signaling by FGFR1 in disease 31 1.29e-01 1.57e-01 2.23e-01
TNFR1-induced proapoptotic signaling 12 3.46e-01 -1.57e-01 4.78e-01
Signaling by PDGF 44 7.17e-02 1.57e-01 1.41e-01
Inositol phosphate metabolism 42 7.89e-02 1.57e-01 1.53e-01
CaM pathway 27 1.59e-01 1.57e-01 2.64e-01
Calmodulin induced events 27 1.59e-01 1.57e-01 2.64e-01
NOD1/2 Signaling Pathway 32 1.26e-01 1.56e-01 2.19e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 3.12e-01 -1.56e-01 4.42e-01
Lysine catabolism 11 3.70e-01 1.56e-01 5.00e-01
Collagen biosynthesis and modifying enzymes 48 6.16e-02 1.56e-01 1.28e-01
Stimuli-sensing channels 73 2.13e-02 1.56e-01 5.67e-02
Adrenaline,noradrenaline inhibits insulin secretion 24 1.87e-01 1.56e-01 2.98e-01
PIWI-interacting RNA (piRNA) biogenesis 23 1.98e-01 -1.55e-01 3.11e-01
Cytosolic sulfonation of small molecules 19 2.43e-01 1.55e-01 3.66e-01
Interconversion of nucleotide di- and triphosphates 27 1.64e-01 -1.55e-01 2.71e-01
Telomere Maintenance 80 1.70e-02 -1.54e-01 4.68e-02
APC/C:Cdc20 mediated degradation of Securin 66 3.02e-02 1.54e-01 7.51e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 3.56e-01 1.54e-01 4.89e-01
Phase 4 - resting membrane potential 10 4.00e-01 1.54e-01 5.33e-01
TCF dependent signaling in response to WNT 165 6.64e-04 1.54e-01 3.49e-03
Transport of small molecules 557 6.70e-10 1.53e-01 1.66e-08
mRNA Splicing - Major Pathway 179 4.27e-04 -1.53e-01 2.40e-03
Interleukin-6 family signaling 18 2.64e-01 1.52e-01 3.91e-01
Pyruvate metabolism 28 1.67e-01 1.51e-01 2.73e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 2.83e-01 -1.51e-01 4.12e-01
PTEN Regulation 138 2.28e-03 1.50e-01 9.41e-03
Regulation of RUNX2 expression and activity 66 3.46e-02 1.50e-01 8.33e-02
Heme biosynthesis 14 3.30e-01 1.50e-01 4.64e-01
G alpha (s) signalling events 141 2.08e-03 1.50e-01 8.87e-03
Fatty acid metabolism 152 1.43e-03 1.50e-01 6.51e-03
Cobalamin (Cbl, vitamin B12) transport and metabolism 16 3.00e-01 -1.50e-01 4.30e-01
TP53 Regulates Metabolic Genes 84 1.78e-02 1.50e-01 4.88e-02
Autodegradation of Cdh1 by Cdh1:APC/C 64 3.86e-02 1.49e-01 9.03e-02
p53-Dependent G1 DNA Damage Response 63 4.08e-02 1.49e-01 9.39e-02
p53-Dependent G1/S DNA damage checkpoint 63 4.08e-02 1.49e-01 9.39e-02
ERBB2 Regulates Cell Motility 10 4.15e-01 1.49e-01 5.48e-01
SCF(Skp2)-mediated degradation of p27/p21 60 4.59e-02 1.49e-01 1.03e-01
Processing of SMDT1 15 3.18e-01 -1.49e-01 4.51e-01
Extra-nuclear estrogen signaling 67 3.52e-02 1.49e-01 8.40e-02
mRNA Splicing 187 4.75e-04 -1.48e-01 2.62e-03
Base-Excision Repair, AP Site Formation 31 1.53e-01 1.48e-01 2.57e-01
Activation of HOX genes during differentiation 68 3.50e-02 1.48e-01 8.35e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 68 3.50e-02 1.48e-01 8.35e-02
ECM proteoglycans 35 1.31e-01 1.47e-01 2.26e-01
CDT1 association with the CDC6:ORC:origin complex 57 5.44e-02 1.47e-01 1.17e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 6.68e-02 1.47e-01 1.36e-01
p75 NTR receptor-mediated signalling 89 1.67e-02 1.47e-01 4.62e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 80 2.33e-02 1.47e-01 6.10e-02
Transmission across Chemical Synapses 172 9.24e-04 1.46e-01 4.62e-03
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 2.38e-01 1.45e-01 3.61e-01
PIP3 activates AKT signaling 239 1.09e-04 1.45e-01 7.77e-04
Signaling by NOTCH2 30 1.69e-01 1.45e-01 2.75e-01
Interleukin-12 signaling 44 9.56e-02 1.45e-01 1.79e-01
Intracellular signaling by second messengers 271 4.01e-05 1.45e-01 3.37e-04
Fatty acyl-CoA biosynthesis 34 1.44e-01 1.45e-01 2.44e-01
mRNA 3'-end processing 56 6.13e-02 -1.45e-01 1.27e-01
Formation of the beta-catenin:TCF transactivating complex 46 9.01e-02 1.44e-01 1.70e-01
Downstream signaling events of B Cell Receptor (BCR) 79 2.68e-02 1.44e-01 6.91e-02
Metabolism of carbohydrates 244 1.10e-04 1.44e-01 7.82e-04
Deubiquitination 241 1.24e-04 1.43e-01 8.51e-04
Depolymerisation of the Nuclear Lamina 15 3.37e-01 1.43e-01 4.71e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 2.89e-02 -1.43e-01 7.24e-02
Signaling by PDGFR in disease 19 2.80e-01 1.43e-01 4.10e-01
Synthesis of PIPs at the Golgi membrane 16 3.23e-01 1.43e-01 4.56e-01
FGFR2 mutant receptor activation 22 2.48e-01 -1.42e-01 3.72e-01
Nuclear Envelope Breakdown 53 7.38e-02 -1.42e-01 1.44e-01
Base Excision Repair 58 6.20e-02 -1.42e-01 1.28e-01
Signal Transduction 1882 5.25e-24 1.41e-01 2.98e-22
Signaling by ERBB4 44 1.07e-01 1.40e-01 1.93e-01
PI-3K cascade:FGFR2 12 4.01e-01 -1.40e-01 5.33e-01
NGF-stimulated transcription 31 1.77e-01 1.40e-01 2.85e-01
Defective B4GALT7 causes EDS, progeroid type 11 4.21e-01 -1.40e-01 5.54e-01
ISG15 antiviral mechanism 72 4.02e-02 -1.40e-01 9.31e-02
HS-GAG biosynthesis 20 2.80e-01 1.39e-01 4.10e-01
Interleukin-20 family signaling 17 3.20e-01 1.39e-01 4.52e-01
RUNX2 regulates osteoblast differentiation 18 3.07e-01 1.39e-01 4.36e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 2.75e-02 -1.39e-01 6.99e-02
Interleukin-12 family signaling 53 8.08e-02 1.39e-01 1.55e-01
Retrograde transport at the Trans-Golgi-Network 49 9.38e-02 1.38e-01 1.76e-01
Transport of vitamins, nucleosides, and related molecules 33 1.69e-01 1.38e-01 2.76e-01
G1/S DNA Damage Checkpoints 65 5.63e-02 1.37e-01 1.21e-01
Metabolism of cofactors 19 3.04e-01 1.36e-01 4.34e-01
Class I MHC mediated antigen processing & presentation 349 1.35e-05 1.36e-01 1.29e-04
Glutathione conjugation 26 2.33e-01 1.35e-01 3.55e-01
Potassium Channels 63 6.39e-02 1.35e-01 1.31e-01
Regulation of FOXO transcriptional activity by acetylation 10 4.61e-01 1.35e-01 5.92e-01
The canonical retinoid cycle in rods (twilight vision) 10 4.62e-01 1.34e-01 5.93e-01
Cellular Senescence 144 5.48e-03 1.34e-01 1.88e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 36 1.66e-01 1.34e-01 2.72e-01
APC-Cdc20 mediated degradation of Nek2A 26 2.39e-01 -1.33e-01 3.62e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 4.44e-01 -1.33e-01 5.77e-01
ESR-mediated signaling 162 3.45e-03 1.33e-01 1.31e-02
TRAF3-dependent IRF activation pathway 13 4.08e-01 1.33e-01 5.40e-01
VEGFR2 mediated vascular permeability 27 2.33e-01 1.33e-01 3.55e-01
Activation of kainate receptors upon glutamate binding 26 2.43e-01 1.32e-01 3.66e-01
RNA Polymerase III Abortive And Retractive Initiation 41 1.44e-01 -1.32e-01 2.44e-01
RNA Polymerase III Transcription 41 1.44e-01 -1.32e-01 2.44e-01
Negative regulation of FGFR2 signaling 23 2.74e-01 1.32e-01 4.03e-01
Circadian Clock 67 6.33e-02 1.31e-01 1.30e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 3.11e-01 -1.31e-01 4.42e-01
VEGFR2 mediated cell proliferation 18 3.36e-01 1.31e-01 4.70e-01
RA biosynthesis pathway 13 4.14e-01 -1.31e-01 5.48e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 3.51e-01 -1.31e-01 4.83e-01
CDK-mediated phosphorylation and removal of Cdc6 71 5.72e-02 1.31e-01 1.21e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 5.08e-02 1.30e-01 1.11e-01
Cilium Assembly 181 2.47e-03 -1.30e-01 9.97e-03
SHC-mediated cascade:FGFR1 12 4.35e-01 1.30e-01 5.68e-01
SIRT1 negatively regulates rRNA expression 24 2.70e-01 1.30e-01 3.98e-01
Signaling by Hedgehog 120 1.39e-02 1.30e-01 3.98e-02
Peptide ligand-binding receptors 92 3.13e-02 1.30e-01 7.69e-02
CD209 (DC-SIGN) signaling 20 3.16e-01 1.29e-01 4.48e-01
Xenobiotics 11 4.60e-01 -1.29e-01 5.92e-01
Gene expression (Transcription) 1326 4.43e-15 -1.28e-01 1.88e-13
Mitotic Telophase/Cytokinesis 13 4.24e-01 1.28e-01 5.55e-01
Cytochrome P450 - arranged by substrate type 34 1.97e-01 1.28e-01 3.11e-01
Ion transport by P-type ATPases 42 1.52e-01 1.28e-01 2.55e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 3.62e-01 -1.28e-01 4.93e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 74 5.81e-02 1.27e-01 1.23e-01
Intrinsic Pathway for Apoptosis 52 1.13e-01 1.27e-01 2.01e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 1.45e-01 1.27e-01 2.45e-01
Neuronal System 258 4.57e-04 1.27e-01 2.54e-03
PKA-mediated phosphorylation of CREB 17 3.66e-01 1.27e-01 4.96e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 3.28e-01 1.26e-01 4.61e-01
Translation of structural proteins 28 2.49e-01 1.26e-01 3.72e-01
CD28 dependent Vav1 pathway 12 4.51e-01 1.26e-01 5.84e-01
Regulation of beta-cell development 19 3.43e-01 1.26e-01 4.76e-01
Ub-specific processing proteases 170 4.89e-03 1.25e-01 1.74e-02
Alpha-protein kinase 1 signaling pathway 11 4.73e-01 1.25e-01 6.00e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 6.71e-02 1.25e-01 1.36e-01
Signaling by Nuclear Receptors 218 1.52e-03 1.25e-01 6.86e-03
FCERI mediated NF-kB activation 137 1.18e-02 -1.25e-01 3.49e-02
Signaling by GPCR 536 8.73e-07 1.24e-01 1.15e-05
Keratinization 32 2.24e-01 1.24e-01 3.44e-01
Integrin cell surface interactions 52 1.23e-01 1.23e-01 2.15e-01
G alpha (q) signalling events 131 1.47e-02 1.23e-01 4.17e-02
Antiviral mechanism by IFN-stimulated genes 80 5.72e-02 -1.23e-01 1.21e-01
DAP12 signaling 28 2.60e-01 1.23e-01 3.87e-01
Degradation of cysteine and homocysteine 12 4.61e-01 1.23e-01 5.92e-01
Post-translational protein modification 1190 9.53e-13 1.23e-01 3.71e-11
MAPK1/MAPK3 signaling 235 1.20e-03 1.23e-01 5.72e-03
FLT3 Signaling 244 9.81e-04 1.23e-01 4.84e-03
FRS-mediated FGFR1 signaling 14 4.28e-01 1.22e-01 5.60e-01
DAG and IP3 signaling 33 2.24e-01 1.22e-01 3.44e-01
SUMOylation of transcription factors 16 3.97e-01 1.22e-01 5.30e-01
Nuclear signaling by ERBB4 24 3.01e-01 1.22e-01 4.31e-01
ABC-family proteins mediated transport 93 4.21e-02 1.22e-01 9.59e-02
Elevation of cytosolic Ca2+ levels 12 4.66e-01 1.21e-01 5.96e-01
Regulation of MECP2 expression and activity 28 2.66e-01 1.21e-01 3.94e-01
Acyl chain remodelling of PE 20 3.47e-01 1.21e-01 4.79e-01
IRF3-mediated induction of type I IFN 12 4.67e-01 -1.21e-01 5.96e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 7.83e-02 1.21e-01 1.52e-01
Synthesis of very long-chain fatty acyl-CoAs 21 3.38e-01 1.21e-01 4.71e-01
Negative regulation of the PI3K/AKT network 87 5.17e-02 1.21e-01 1.12e-01
Syndecan interactions 19 3.63e-01 1.21e-01 4.94e-01
GPCR downstream signalling 494 4.46e-06 1.21e-01 4.97e-05
Nucleobase catabolism 28 2.72e-01 1.20e-01 4.00e-01
Assembly of collagen fibrils and other multimeric structures 42 1.80e-01 1.20e-01 2.88e-01
O-glycosylation of TSR domain-containing proteins 27 2.84e-01 -1.19e-01 4.13e-01
Cell death signalling via NRAGE, NRIF and NADE 70 8.51e-02 1.19e-01 1.62e-01
Synthesis of PE 12 4.76e-01 -1.19e-01 6.02e-01
Transcriptional regulation by RUNX1 184 5.69e-03 1.18e-01 1.94e-02
Nucleotide Excision Repair 110 3.26e-02 -1.18e-01 7.93e-02
Meiotic synapsis 45 1.71e-01 1.18e-01 2.79e-01
Generic Transcription Pathway 1077 6.54e-11 -1.18e-01 1.89e-09
RAF/MAP kinase cascade 230 2.25e-03 1.17e-01 9.36e-03
Signaling by TGF-beta Receptor Complex 72 8.66e-02 1.17e-01 1.64e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 3.91e-01 1.17e-01 5.24e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 3.91e-01 1.17e-01 5.24e-01
Repression of WNT target genes 14 4.50e-01 -1.17e-01 5.83e-01
Striated Muscle Contraction 23 3.33e-01 1.17e-01 4.67e-01
MAPK family signaling cascades 269 1.04e-03 1.16e-01 5.07e-03
RAF-independent MAPK1/3 activation 21 3.57e-01 1.16e-01 4.89e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 4.23e-01 1.16e-01 5.55e-01
Synthesis of DNA 118 3.00e-02 -1.16e-01 7.45e-02
Ovarian tumor domain proteases 37 2.26e-01 1.15e-01 3.46e-01
Other semaphorin interactions 16 4.28e-01 1.14e-01 5.61e-01
Synthesis, secretion, and deacylation of Ghrelin 12 4.95e-01 -1.14e-01 6.21e-01
Vitamin B5 (pantothenate) metabolism 17 4.19e-01 1.13e-01 5.53e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 3.58e-01 1.13e-01 4.90e-01
Regulation of TP53 Activity 151 1.64e-02 -1.13e-01 4.56e-02
S Phase 160 1.36e-02 -1.13e-01 3.89e-02
Biosynthesis of DHA-derived SPMs 14 4.64e-01 1.13e-01 5.94e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 2.41e-01 1.13e-01 3.65e-01
Pexophagy 11 5.18e-01 1.13e-01 6.41e-01
Insulin receptor signalling cascade 39 2.25e-01 1.12e-01 3.45e-01
Unfolded Protein Response (UPR) 86 7.37e-02 1.12e-01 1.44e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 12 5.04e-01 -1.11e-01 6.30e-01
G alpha (i) signalling events 244 2.91e-03 1.11e-01 1.14e-02
FGFR2 alternative splicing 25 3.41e-01 -1.10e-01 4.74e-01
RNA Polymerase II Transcription 1196 1.85e-10 -1.09e-01 5.13e-09
Ca2+ pathway 57 1.53e-01 1.09e-01 2.57e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 4.81e-01 1.09e-01 6.06e-01
Heparan sulfate/heparin (HS-GAG) metabolism 37 2.54e-01 1.08e-01 3.78e-01
mRNA decay by 5' to 3' exoribonuclease 15 4.69e-01 -1.08e-01 5.97e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 32 2.96e-01 1.07e-01 4.27e-01
Signaling by ERBB2 44 2.22e-01 1.06e-01 3.43e-01
DNA Repair 289 2.16e-03 -1.05e-01 9.08e-03
SLC-mediated transmembrane transport 180 1.55e-02 1.05e-01 4.35e-02
Peptide hormone metabolism 51 1.97e-01 1.04e-01 3.11e-01
Signaling by FGFR3 in disease 13 5.15e-01 -1.04e-01 6.39e-01
Signaling by FGFR3 point mutants in cancer 13 5.15e-01 -1.04e-01 6.39e-01
SHC-mediated cascade:FGFR2 12 5.34e-01 -1.04e-01 6.53e-01
Gene Silencing by RNA 87 9.61e-02 -1.03e-01 1.79e-01
Defective B3GAT3 causes JDSSDHD 11 5.55e-01 -1.03e-01 6.73e-01
Processing of Intronless Pre-mRNAs 19 4.39e-01 -1.02e-01 5.71e-01
DNA Replication 125 4.82e-02 -1.02e-01 1.07e-01
Methylation 12 5.40e-01 -1.02e-01 6.59e-01
Regulation of TP53 Activity through Phosphorylation 88 9.82e-02 -1.02e-01 1.81e-01
Death Receptor Signalling 132 4.38e-02 1.02e-01 9.86e-02
Metal ion SLC transporters 21 4.21e-01 1.02e-01 5.54e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 4.69e-01 -1.01e-01 5.97e-01
Transcriptional Regulation by MECP2 47 2.30e-01 1.01e-01 3.51e-01
Signaling by TGFB family members 91 9.60e-02 1.01e-01 1.79e-01
Regulation of TNFR1 signaling 32 3.24e-01 -1.01e-01 4.56e-01
Regulation of innate immune responses to cytosolic DNA 14 5.14e-01 -1.01e-01 6.39e-01
Assembly of the pre-replicative complex 66 1.58e-01 1.01e-01 2.63e-01
Downstream signaling of activated FGFR1 20 4.37e-01 1.00e-01 5.68e-01
Cell junction organization 59 1.83e-01 1.00e-01 2.92e-01
RNA Polymerase I Promoter Clearance 66 1.60e-01 -1.00e-01 2.65e-01
RNA Polymerase I Transcription 66 1.60e-01 -1.00e-01 2.65e-01
ADORA2B mediated anti-inflammatory cytokines production 73 1.40e-01 1.00e-01 2.37e-01
Signaling by FGFR2 in disease 32 3.28e-01 -9.99e-02 4.61e-01
Signalling to RAS 19 4.51e-01 9.98e-02 5.84e-01
Hedgehog 'off' state 92 9.86e-02 9.96e-02 1.82e-01
Cellular hexose transport 15 5.05e-01 -9.93e-02 6.30e-01
Purine catabolism 16 4.94e-01 -9.87e-02 6.21e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 3.86e-01 -9.83e-02 5.18e-01
Nicotinate metabolism 25 3.95e-01 9.83e-02 5.29e-01
PRC2 methylates histones and DNA 29 3.60e-01 9.82e-02 4.91e-01
Synthesis of PIPs at the early endosome membrane 16 5.00e-01 9.75e-02 6.27e-01
Phase I - Functionalization of compounds 63 1.81e-01 9.75e-02 2.89e-01
SHC1 events in ERBB4 signaling 10 5.94e-01 9.73e-02 7.07e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 4.11e-01 -9.70e-02 5.44e-01
CRMPs in Sema3A signaling 14 5.30e-01 9.69e-02 6.50e-01
G1/S Transition 130 6.25e-02 -9.46e-02 1.29e-01
Other interleukin signaling 18 4.88e-01 9.44e-02 6.14e-01
HCMV Late Events 69 1.75e-01 9.44e-02 2.83e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 26 4.07e-01 -9.40e-02 5.40e-01
PI-3K cascade:FGFR1 12 5.74e-01 9.37e-02 6.90e-01
Cardiac conduction 92 1.20e-01 9.37e-02 2.12e-01
Signaling by NTRK2 (TRKB) 20 4.69e-01 9.36e-02 5.97e-01
Cell-Cell communication 87 1.32e-01 9.35e-02 2.26e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 4.59e-01 9.34e-02 5.91e-01
Estrogen-dependent gene expression 99 1.09e-01 9.32e-02 1.96e-01
Phosphorylation of the APC/C 20 4.71e-01 -9.30e-02 5.99e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 4.21e-01 -9.30e-02 5.54e-01
Homology Directed Repair 110 9.21e-02 -9.30e-02 1.73e-01
SUMOylation 165 3.95e-02 -9.29e-02 9.22e-02
Cytokine Signaling in Immune system 735 1.81e-05 9.29e-02 1.71e-04
Aggrephagy 22 4.54e-01 9.23e-02 5.86e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 29 3.96e-01 9.11e-02 5.29e-01
Mitochondrial calcium ion transport 22 4.60e-01 -9.10e-02 5.92e-01
Pregnenolone biosynthesis 10 6.20e-01 9.05e-02 7.27e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 6.04e-01 -9.04e-02 7.17e-01
Formation of Incision Complex in GG-NER 43 3.06e-01 -9.02e-02 4.36e-01
DNA Double-Strand Break Repair 135 7.05e-02 -9.01e-02 1.40e-01
Signaling by Activin 10 6.22e-01 -9.01e-02 7.29e-01
Formation of tubulin folding intermediates by CCT/TriC 22 4.67e-01 8.96e-02 5.96e-01
TP53 Regulates Transcription of DNA Repair Genes 61 2.29e-01 -8.90e-02 3.50e-01
GABA synthesis, release, reuptake and degradation 13 5.81e-01 -8.85e-02 6.96e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 5.28e-01 8.84e-02 6.48e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 5.28e-01 8.84e-02 6.48e-01
NRAGE signals death through JNK 53 2.66e-01 8.83e-02 3.94e-01
FOXO-mediated transcription 58 2.45e-01 8.82e-02 3.69e-01
Zinc transporters 14 5.71e-01 8.75e-02 6.88e-01
Anti-inflammatory response favouring Leishmania parasite infection 169 5.02e-02 -8.73e-02 1.10e-01
Leishmania parasite growth and survival 169 5.02e-02 -8.73e-02 1.10e-01
Signaling by the B Cell Receptor (BCR) 162 5.59e-02 -8.70e-02 1.20e-01
Interleukin-2 signaling 11 6.18e-01 8.67e-02 7.27e-01
Neddylation 218 2.74e-02 8.67e-02 6.98e-02
Resolution of D-loop Structures through Holliday Junction Intermediates 32 3.97e-01 -8.65e-02 5.30e-01
Meiotic recombination 38 3.59e-01 8.60e-02 4.90e-01
SUMO E3 ligases SUMOylate target proteins 159 6.17e-02 -8.59e-02 1.28e-01
Mitophagy 28 4.33e-01 -8.57e-02 5.66e-01
Class A/1 (Rhodopsin-like receptors) 162 6.01e-02 8.56e-02 1.26e-01
Ion homeostasis 40 3.53e-01 8.49e-02 4.85e-01
Nonhomologous End-Joining (NHEJ) 42 3.41e-01 8.49e-02 4.74e-01
PI3K/AKT Signaling in Cancer 80 1.89e-01 8.49e-02 3.01e-01
Purine salvage 12 6.15e-01 8.40e-02 7.26e-01
Laminin interactions 21 5.06e-01 8.38e-02 6.30e-01
APC/C-mediated degradation of cell cycle proteins 86 1.79e-01 8.38e-02 2.88e-01
Regulation of mitotic cell cycle 86 1.79e-01 8.38e-02 2.88e-01
Endosomal/Vacuolar pathway 12 6.17e-01 -8.33e-02 7.27e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 6.36e-01 -8.24e-02 7.42e-01
Nitric oxide stimulates guanylate cyclase 16 5.68e-01 8.24e-02 6.86e-01
Synthesis of substrates in N-glycan biosythesis 58 2.80e-01 8.21e-02 4.10e-01
Activation of RAC1 11 6.40e-01 8.13e-02 7.45e-01
Positive epigenetic regulation of rRNA expression 62 2.69e-01 -8.12e-02 3.96e-01
The citric acid (TCA) cycle and respiratory electron transport 172 6.61e-02 8.12e-02 1.35e-01
The phototransduction cascade 25 4.83e-01 -8.11e-02 6.08e-01
HSF1 activation 26 4.76e-01 -8.08e-02 6.02e-01
Regulation of TP53 Expression and Degradation 36 4.02e-01 -8.08e-02 5.34e-01
NCAM signaling for neurite out-growth 43 3.64e-01 -8.00e-02 4.95e-01
Metabolism 1768 2.61e-08 7.97e-02 5.01e-07
Cyclin E associated events during G1/S transition 83 2.10e-01 7.95e-02 3.27e-01
Keratan sulfate biosynthesis 22 5.21e-01 7.90e-02 6.43e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 5.65e-01 -7.84e-02 6.82e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 6.38e-01 7.84e-02 7.44e-01
Regulation of TP53 Degradation 35 4.23e-01 -7.83e-02 5.55e-01
FRS-mediated FGFR2 signaling 14 6.13e-01 -7.80e-02 7.25e-01
Nephrin family interactions 17 5.79e-01 -7.78e-02 6.94e-01
Phase II - Conjugation of compounds 68 2.69e-01 7.76e-02 3.96e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 6.71e-01 -7.76e-02 7.71e-01
Defective EXT2 causes exostoses 2 10 6.71e-01 -7.76e-02 7.71e-01
Phase 0 - rapid depolarisation 28 4.78e-01 -7.75e-02 6.04e-01
Establishment of Sister Chromatid Cohesion 11 6.57e-01 -7.74e-02 7.59e-01
Signaling by ERBB2 ECD mutants 15 6.05e-01 7.72e-02 7.17e-01
Epigenetic regulation of gene expression 103 1.77e-01 -7.70e-02 2.85e-01
Disorders of transmembrane transporters 147 1.09e-01 7.66e-02 1.96e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 3.69e-01 7.66e-02 5.00e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 5.54e-01 -7.64e-02 6.73e-01
Glucose metabolism 84 2.27e-01 7.63e-02 3.46e-01
Antigen processing: Ubiquitination & Proteasome degradation 288 2.71e-02 7.57e-02 6.94e-02
Polo-like kinase mediated events 16 6.01e-01 7.55e-02 7.14e-01
Mitotic Anaphase 223 5.30e-02 7.52e-02 1.15e-01
CDC6 association with the ORC:origin complex 11 6.66e-01 -7.51e-02 7.67e-01
Regulation of APC/C activators between G1/S and early anaphase 79 2.49e-01 7.50e-02 3.72e-01
DNA Double Strand Break Response 47 3.77e-01 7.45e-02 5.08e-01
Resolution of D-Loop Structures 33 4.67e-01 -7.32e-02 5.96e-01
Organelle biogenesis and maintenance 269 3.98e-02 -7.28e-02 9.27e-02
Protein methylation 15 6.26e-01 -7.27e-02 7.33e-01
Regulation of necroptotic cell death 14 6.39e-01 -7.25e-02 7.44e-01
HCMV Early Events 74 2.83e-01 -7.21e-02 4.13e-01
RNA polymerase II transcribes snRNA genes 72 2.92e-01 7.18e-02 4.23e-01
Downregulation of TGF-beta receptor signaling 26 5.27e-01 7.16e-02 6.48e-01
Activation of SMO 13 6.59e-01 7.07e-02 7.60e-01
Mitotic Metaphase and Anaphase 224 6.87e-02 7.06e-02 1.39e-01
MicroRNA (miRNA) biogenesis 24 5.50e-01 -7.05e-02 6.70e-01
Glucagon-type ligand receptors 20 5.86e-01 7.04e-02 7.01e-01
Glyoxylate metabolism and glycine degradation 24 5.51e-01 -7.04e-02 6.70e-01
tRNA processing in the mitochondrion 30 5.07e-01 -7.00e-02 6.31e-01
Neurotransmitter release cycle 39 4.51e-01 6.97e-02 5.84e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 2.19e-01 -6.97e-02 3.40e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 6.52e-01 6.96e-02 7.56e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 6.52e-01 6.96e-02 7.56e-01
Developmental Biology 727 1.41e-03 6.96e-02 6.44e-03
Post-translational modification: synthesis of GPI-anchored proteins 57 3.65e-01 6.94e-02 4.95e-01
GPCR ligand binding 229 7.13e-02 6.92e-02 1.41e-01
mRNA Capping 29 5.21e-01 -6.88e-02 6.43e-01
HIV elongation arrest and recovery 32 5.02e-01 6.86e-02 6.28e-01
Pausing and recovery of HIV elongation 32 5.02e-01 6.86e-02 6.28e-01
Anchoring of the basal body to the plasma membrane 97 2.46e-01 -6.82e-02 3.70e-01
Formation of RNA Pol II elongation complex 57 3.74e-01 6.81e-02 5.05e-01
RNA Polymerase II Transcription Elongation 57 3.74e-01 6.81e-02 5.05e-01
Respiratory electron transport 101 2.37e-01 6.81e-02 3.61e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 6.83e-01 6.80e-02 7.80e-01
HCMV Infection 96 2.50e-01 6.80e-02 3.73e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 5.58e-01 6.77e-02 6.75e-01
Biological oxidations 136 1.74e-01 6.76e-02 2.82e-01
Cyclin A:Cdk2-associated events at S phase entry 85 2.82e-01 6.75e-02 4.12e-01
Regulation of PTEN gene transcription 59 3.72e-01 6.72e-02 5.02e-01
FRS-mediated FGFR3 signaling 11 7.01e-01 6.68e-02 7.96e-01
Incretin synthesis, secretion, and inactivation 10 7.15e-01 6.66e-02 8.07e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 10 7.15e-01 6.66e-02 8.07e-01
Molecules associated with elastic fibres 22 5.89e-01 6.66e-02 7.04e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 124 2.01e-01 6.66e-02 3.14e-01
Nucleotide-like (purinergic) receptors 12 6.92e-01 6.61e-02 7.88e-01
Visual phototransduction 59 3.82e-01 6.58e-02 5.14e-01
Complex I biogenesis 55 3.99e-01 6.57e-02 5.32e-01
TRP channels 17 6.40e-01 6.54e-02 7.45e-01
Dopamine Neurotransmitter Release Cycle 20 6.13e-01 -6.54e-02 7.25e-01
Amino acid transport across the plasma membrane 23 5.90e-01 6.49e-02 7.05e-01
Cohesin Loading onto Chromatin 10 7.24e-01 6.45e-02 8.11e-01
Sema3A PAK dependent Axon repulsion 16 6.55e-01 6.45e-02 7.57e-01
Aflatoxin activation and detoxification 14 6.77e-01 6.42e-02 7.75e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 6.90e-01 -6.40e-02 7.86e-01
Neurexins and neuroligins 37 5.04e-01 -6.35e-02 6.29e-01
Acyl chain remodelling of PS 14 6.82e-01 6.33e-02 7.79e-01
Leishmania infection 245 8.82e-02 6.32e-02 1.67e-01
Eicosanoid ligand-binding receptors 13 6.95e-01 -6.28e-02 7.90e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 63 3.92e-01 6.24e-02 5.25e-01
Signaling by FGFR4 in disease 11 7.21e-01 -6.23e-02 8.11e-01
Recruitment of NuMA to mitotic centrosomes 80 3.36e-01 -6.22e-02 4.70e-01
PERK regulates gene expression 30 5.57e-01 -6.19e-02 6.75e-01
Ephrin signaling 17 6.59e-01 6.18e-02 7.60e-01
Mitotic Prophase 98 2.91e-01 6.18e-02 4.21e-01
Branched-chain amino acid catabolism 21 6.28e-01 -6.11e-02 7.34e-01
Diseases associated with glycosaminoglycan metabolism 26 5.90e-01 6.10e-02 7.05e-01
DNA Damage Recognition in GG-NER 38 5.16e-01 -6.08e-02 6.40e-01
p75NTR signals via NF-kB 15 6.84e-01 6.08e-02 7.80e-01
Centrosome maturation 81 3.45e-01 -6.07e-02 4.77e-01
Recruitment of mitotic centrosome proteins and complexes 81 3.45e-01 -6.07e-02 4.77e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 5.59e-01 -6.06e-02 6.76e-01
N-Glycan antennae elongation 13 7.07e-01 6.02e-02 7.99e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 7.31e-01 5.98e-02 8.16e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 5.91e-01 -5.98e-02 7.05e-01
Deadenylation of mRNA 22 6.28e-01 -5.98e-02 7.34e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 5.24e-01 5.97e-02 6.46e-01
Pausing and recovery of Tat-mediated HIV elongation 30 5.74e-01 5.93e-02 6.90e-01
Tat-mediated HIV elongation arrest and recovery 30 5.74e-01 5.93e-02 6.90e-01
Formation of TC-NER Pre-Incision Complex 53 4.57e-01 -5.90e-02 5.90e-01
Diseases associated with N-glycosylation of proteins 17 6.75e-01 -5.88e-02 7.73e-01
Metabolism of nucleotides 86 3.47e-01 -5.87e-02 4.79e-01
Collagen chain trimerization 27 5.98e-01 -5.86e-02 7.12e-01
Inactivation, recovery and regulation of the phototransduction cascade 24 6.20e-01 -5.85e-02 7.27e-01
Diseases associated with O-glycosylation of proteins 49 4.79e-01 -5.84e-02 6.05e-01
Nuclear Envelope (NE) Reassembly 69 4.04e-01 5.81e-02 5.37e-01
RHO GTPases Activate Formins 117 2.78e-01 5.80e-02 4.09e-01
PKMTs methylate histone lysines 44 5.06e-01 -5.79e-02 6.30e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 3.78e-01 5.73e-02 5.09e-01
Activation of BH3-only proteins 29 5.93e-01 5.73e-02 7.07e-01
Disease 1299 5.48e-04 5.71e-02 2.98e-03
Diseases of metabolism 190 1.75e-01 5.71e-02 2.83e-01
NRIF signals cell death from the nucleus 15 7.02e-01 5.70e-02 7.96e-01
HATs acetylate histones 93 3.42e-01 -5.70e-02 4.75e-01
M Phase 360 6.37e-02 5.69e-02 1.31e-01
TP53 Regulates Transcription of Cell Death Genes 42 5.26e-01 5.65e-02 6.47e-01
Downstream signaling of activated FGFR2 19 6.72e-01 -5.61e-02 7.72e-01
Signaling by FGFR 69 4.22e-01 5.59e-02 5.54e-01
Negative regulators of DDX58/IFIH1 signaling 34 5.75e-01 -5.56e-02 6.90e-01
Separation of Sister Chromatids 167 2.17e-01 5.54e-02 3.36e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 6.61e-01 5.53e-02 7.61e-01
Glycolysis 67 4.37e-01 5.50e-02 5.68e-01
Cyclin D associated events in G1 47 5.18e-01 5.45e-02 6.41e-01
G1 Phase 47 5.18e-01 5.45e-02 6.41e-01
Transcriptional activation of mitochondrial biogenesis 51 5.03e-01 5.42e-02 6.29e-01
Signaling by ERBB2 in Cancer 21 6.77e-01 5.25e-02 7.75e-01
Mitotic G2-G2/M phases 182 2.24e-01 5.23e-02 3.44e-01
MECP2 regulates neuronal receptors and channels 13 7.45e-01 5.21e-02 8.24e-01
Termination of O-glycan biosynthesis 16 7.23e-01 5.12e-02 8.11e-01
Class I peroxisomal membrane protein import 20 6.92e-01 -5.11e-02 7.88e-01
Cargo trafficking to the periciliary membrane 47 5.47e-01 -5.07e-02 6.68e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 6.75e-01 5.05e-02 7.73e-01
RNA Polymerase I Promoter Escape 47 5.50e-01 -5.04e-02 6.70e-01
Metabolism of vitamins and cofactors 155 2.80e-01 5.03e-02 4.10e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 5.50e-01 -4.99e-02 6.70e-01
MET activates PTK2 signaling 15 7.39e-01 4.97e-02 8.20e-01
Processing of DNA double-strand break ends 71 4.72e-01 -4.94e-02 5.99e-01
RMTs methylate histone arginines 37 6.04e-01 -4.93e-02 7.17e-01
Metabolism of folate and pterines 16 7.34e-01 4.91e-02 8.18e-01
Voltage gated Potassium channels 25 6.73e-01 4.88e-02 7.72e-01
Signaling by FGFR2 IIIa TM 18 7.21e-01 -4.87e-02 8.11e-01
Selective autophagy 58 5.22e-01 4.86e-02 6.44e-01
Class B/2 (Secretin family receptors) 56 5.33e-01 4.82e-02 6.52e-01
SLC transporter disorders 77 4.70e-01 -4.76e-02 5.98e-01
Downstream signaling of activated FGFR3 16 7.42e-01 4.76e-02 8.21e-01
RIPK1-mediated regulated necrosis 16 7.42e-01 4.76e-02 8.21e-01
Regulated Necrosis 16 7.42e-01 4.76e-02 8.21e-01
Signaling by FGFR in disease 51 5.57e-01 4.75e-02 6.75e-01
Interleukin-7 signaling 21 7.07e-01 4.74e-02 7.99e-01
PI-3K cascade:FGFR4 10 7.97e-01 -4.71e-02 8.67e-01
Metabolism of proteins 1715 1.29e-03 4.68e-02 6.03e-03
RNA Polymerase II Pre-transcription Events 78 4.75e-01 4.68e-02 6.02e-01
Transcriptional Regulation by VENTX 38 6.18e-01 -4.67e-02 7.27e-01
Interferon Signaling 177 2.85e-01 -4.66e-02 4.14e-01
DCC mediated attractive signaling 13 7.72e-01 -4.65e-02 8.44e-01
Mitochondrial biogenesis 88 4.52e-01 4.64e-02 5.84e-01
Mitotic G1 phase and G1/S transition 148 3.32e-01 -4.62e-02 4.66e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 7.37e-01 4.57e-02 8.20e-01
CTLA4 inhibitory signaling 21 7.18e-01 4.56e-02 8.09e-01
G2/M Transition 180 2.99e-01 4.49e-02 4.30e-01
Glutathione synthesis and recycling 10 8.06e-01 -4.49e-02 8.73e-01
HIV Life Cycle 144 3.59e-01 -4.43e-02 4.90e-01
DNA Replication Pre-Initiation 82 4.89e-01 -4.42e-02 6.15e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 6.18e-01 4.39e-02 7.27e-01
Norepinephrine Neurotransmitter Release Cycle 14 7.77e-01 -4.38e-02 8.49e-01
Orc1 removal from chromatin 69 5.34e-01 4.33e-02 6.53e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 8.07e-01 4.26e-02 8.73e-01
Regulation of PTEN mRNA translation 13 7.95e-01 4.15e-02 8.67e-01
Adaptive Immune System 756 5.25e-02 4.14e-02 1.14e-01
HS-GAG degradation 16 7.75e-01 4.12e-02 8.47e-01
Cell surface interactions at the vascular wall 174 3.53e-01 -4.09e-02 4.85e-01
Netrin-1 signaling 40 6.55e-01 4.08e-02 7.57e-01
TNFR1-induced NFkappaB signaling pathway 25 7.29e-01 -4.01e-02 8.14e-01
Glutamate Neurotransmitter Release Cycle 20 7.57e-01 -4.00e-02 8.33e-01
Downregulation of ERBB2:ERBB3 signaling 12 8.10e-01 -4.00e-02 8.75e-01
Prefoldin mediated transfer of substrate to CCT/TriC 26 7.25e-01 3.99e-02 8.11e-01
NF-kB is activated and signals survival 12 8.11e-01 3.98e-02 8.76e-01
Mitotic Prometaphase 185 3.52e-01 -3.96e-02 4.85e-01
Prolactin receptor signaling 11 8.21e-01 -3.95e-02 8.82e-01
Receptor-type tyrosine-protein phosphatases 12 8.16e-01 3.88e-02 8.80e-01
IRAK2 mediated activation of TAK1 complex 10 8.33e-01 3.85e-02 8.92e-01
Attenuation phase 23 7.50e-01 3.84e-02 8.28e-01
Fc epsilon receptor (FCERI) signaling 190 3.66e-01 -3.81e-02 4.96e-01
Signaling by BMP 21 7.64e-01 -3.79e-02 8.38e-01
Interaction between L1 and Ankyrins 22 7.60e-01 -3.76e-02 8.36e-01
Transcriptional regulation by small RNAs 63 6.10e-01 -3.71e-02 7.23e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 8.04e-01 3.69e-02 8.72e-01
HIV Infection 224 3.43e-01 3.67e-02 4.76e-01
Synthesis of PA 32 7.24e-01 3.61e-02 8.11e-01
p75NTR recruits signalling complexes 12 8.29e-01 3.61e-02 8.90e-01
Interleukin-35 Signalling 12 8.31e-01 -3.57e-02 8.91e-01
G2/M DNA damage checkpoint 68 6.26e-01 -3.42e-02 7.33e-01
IGF1R signaling cascade 36 7.29e-01 3.34e-02 8.14e-01
Cristae formation 31 7.49e-01 3.31e-02 8.28e-01
Cell Cycle 624 1.67e-01 -3.24e-02 2.73e-01
Negative epigenetic regulation of rRNA expression 65 6.53e-01 -3.23e-02 7.56e-01
Post NMDA receptor activation events 48 7.03e-01 3.18e-02 7.96e-01
Mitotic Spindle Checkpoint 108 5.69e-01 -3.17e-02 6.86e-01
Nervous system development 474 2.52e-01 3.07e-02 3.75e-01
Chromatin modifying enzymes 217 4.36e-01 3.07e-02 5.68e-01
Chromatin organization 217 4.36e-01 3.07e-02 5.68e-01
Axon guidance 455 2.92e-01 2.89e-02 4.22e-01
Downstream TCR signaling 100 6.18e-01 -2.89e-02 7.27e-01
Non-integrin membrane-ECM interactions 37 7.61e-01 2.88e-02 8.36e-01
Miscellaneous transport and binding events 20 8.32e-01 2.73e-02 8.92e-01
Deposition of new CENPA-containing nucleosomes at the centromere 40 7.66e-01 -2.73e-02 8.38e-01
Nucleosome assembly 40 7.66e-01 -2.73e-02 8.38e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 8.08e-01 -2.71e-02 8.73e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 8.08e-01 -2.71e-02 8.73e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 6.94e-01 2.66e-02 7.89e-01
B-WICH complex positively regulates rRNA expression 47 7.53e-01 -2.65e-02 8.29e-01
Processing and activation of SUMO 10 8.88e-01 -2.58e-02 9.37e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 8.33e-01 2.54e-02 8.92e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 8.87e-01 2.46e-02 9.37e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 7.98e-01 -2.46e-02 8.68e-01
Diseases of mitotic cell cycle 36 7.98e-01 -2.46e-02 8.68e-01
Blood group systems biosynthesis 17 8.64e-01 2.40e-02 9.18e-01
Regulation of PLK1 Activity at G2/M Transition 87 7.02e-01 -2.38e-02 7.96e-01
Late Phase of HIV Life Cycle 131 6.46e-01 -2.32e-02 7.50e-01
Lewis blood group biosynthesis 13 8.85e-01 2.32e-02 9.35e-01
CASP8 activity is inhibited 11 8.94e-01 -2.31e-02 9.38e-01
Dimerization of procaspase-8 11 8.94e-01 -2.31e-02 9.38e-01
Regulation by c-FLIP 11 8.94e-01 -2.31e-02 9.38e-01
STING mediated induction of host immune responses 15 8.77e-01 2.30e-02 9.29e-01
Signaling by KIT in disease 20 8.60e-01 2.27e-02 9.16e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 8.60e-01 2.27e-02 9.16e-01
Downregulation of ERBB2 signaling 24 8.49e-01 2.25e-02 9.07e-01
PI3K events in ERBB2 signaling 11 8.97e-01 2.25e-02 9.38e-01
IL-6-type cytokine receptor ligand interactions 12 8.93e-01 -2.23e-02 9.38e-01
WNT ligand biogenesis and trafficking 21 8.60e-01 2.22e-02 9.16e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 6.42e-01 2.22e-02 7.46e-01
Loss of Nlp from mitotic centrosomes 69 7.53e-01 -2.19e-02 8.29e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 7.53e-01 -2.19e-02 8.29e-01
O-linked glycosylation 84 7.31e-01 2.17e-02 8.16e-01
Sulfur amino acid metabolism 23 8.58e-01 2.16e-02 9.16e-01
Interferon gamma signaling 83 7.35e-01 -2.15e-02 8.19e-01
Kinesins 39 8.18e-01 2.13e-02 8.81e-01
Meiosis 68 7.64e-01 2.11e-02 8.38e-01
Mitochondrial iron-sulfur cluster biogenesis 13 8.97e-01 2.08e-02 9.38e-01
Maturation of nucleoprotein 10 9.15e-01 1.95e-02 9.50e-01
CLEC7A (Dectin-1) induces NFAT activation 11 9.11e-01 -1.95e-02 9.47e-01
FCGR3A-mediated phagocytosis 121 7.22e-01 -1.87e-02 8.11e-01
Leishmania phagocytosis 121 7.22e-01 -1.87e-02 8.11e-01
Parasite infection 121 7.22e-01 -1.87e-02 8.11e-01
Reproduction 80 7.87e-01 1.74e-02 8.59e-01
SUMOylation of transcription cofactors 44 8.45e-01 1.71e-02 9.03e-01
Host Interactions of HIV factors 129 7.39e-01 -1.70e-02 8.20e-01
Regulation of RUNX1 Expression and Activity 18 9.02e-01 1.68e-02 9.40e-01
Basigin interactions 23 8.94e-01 1.61e-02 9.38e-01
Signaling by ERBB2 KD Mutants 20 9.02e-01 1.58e-02 9.40e-01
Signaling by NTRK3 (TRKC) 16 9.14e-01 1.56e-02 9.50e-01
Diseases of glycosylation 109 7.79e-01 1.55e-02 8.51e-01
Transcriptional Regulation by TP53 351 6.20e-01 -1.54e-02 7.27e-01
Cellular responses to external stimuli 505 5.54e-01 1.54e-02 6.73e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 8.74e-01 1.52e-02 9.27e-01
TNFR2 non-canonical NF-kB pathway 95 8.02e-01 1.49e-02 8.70e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 9.35e-01 -1.49e-02 9.66e-01
Activation of NMDA receptors and postsynaptic events 58 8.45e-01 1.49e-02 9.03e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 9.32e-01 -1.48e-02 9.66e-01
Association of TriC/CCT with target proteins during biosynthesis 37 8.83e-01 1.40e-02 9.34e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 8.19e-01 -1.39e-02 8.81e-01
Amplification of signal from the kinetochores 91 8.19e-01 -1.39e-02 8.81e-01
Constitutive Signaling by Aberrant PI3K in Cancer 54 8.62e-01 1.37e-02 9.17e-01
Serotonin Neurotransmitter Release Cycle 15 9.30e-01 -1.32e-02 9.64e-01
Formation of the Early Elongation Complex 33 8.96e-01 -1.31e-02 9.38e-01
Formation of the HIV-1 Early Elongation Complex 33 8.96e-01 -1.31e-02 9.38e-01
TNF signaling 42 8.83e-01 -1.31e-02 9.34e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 9.37e-01 1.26e-02 9.67e-01
Transcription of the HIV genome 67 8.62e-01 -1.23e-02 9.17e-01
Protein-protein interactions at synapses 57 8.74e-01 1.21e-02 9.27e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 8.93e-01 -1.20e-02 9.38e-01
HIV Transcription Elongation 42 8.93e-01 -1.20e-02 9.38e-01
Tat-mediated elongation of the HIV-1 transcript 42 8.93e-01 -1.20e-02 9.38e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 37 9.00e-01 1.19e-02 9.40e-01
GRB2 events in ERBB2 signaling 11 9.50e-01 1.10e-02 9.75e-01
Signaling by NODAL 13 9.47e-01 -1.06e-02 9.73e-01
FOXO-mediated transcription of cell cycle genes 15 9.43e-01 -1.06e-02 9.71e-01
Chaperone Mediated Autophagy 20 9.35e-01 1.05e-02 9.66e-01
Cell-cell junction organization 38 9.11e-01 1.05e-02 9.47e-01
IRS-related events triggered by IGF1R 35 9.16e-01 1.03e-02 9.50e-01
Lysosphingolipid and LPA receptors 11 9.53e-01 -1.03e-02 9.75e-01
Signaling by ERBB2 TMD/JMD mutants 17 9.42e-01 1.02e-02 9.70e-01
FRS-mediated FGFR4 signaling 12 9.53e-01 9.91e-03 9.75e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 9.37e-01 -9.34e-03 9.67e-01
Cell Cycle Checkpoints 259 8.00e-01 -9.16e-03 8.69e-01
Cell Cycle, Mitotic 502 7.37e-01 -8.74e-03 8.20e-01
Downstream signaling of activated FGFR4 17 9.51e-01 8.58e-03 9.75e-01
Cellular responses to stress 499 7.44e-01 8.55e-03 8.23e-01
TCR signaling 121 8.74e-01 -8.35e-03 9.27e-01
Switching of origins to a post-replicative state 89 8.98e-01 7.82e-03 9.38e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 9.65e-01 -6.69e-03 9.83e-01
RAS processing 19 9.61e-01 6.51e-03 9.81e-01
PI3K Cascade 30 9.53e-01 -6.24e-03 9.75e-01
Phase 2 - plateau phase 18 9.64e-01 6.22e-03 9.82e-01
Signaling by FGFR2 60 9.38e-01 5.80e-03 9.67e-01
G2/M Checkpoints 139 9.08e-01 5.65e-03 9.46e-01
Nuclear Receptor transcription pathway 36 9.58e-01 5.12e-03 9.78e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 9.61e-01 -4.84e-03 9.81e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 10 9.80e-01 -4.61e-03 9.92e-01
Regulation of actin dynamics for phagocytic cup formation 123 9.34e-01 -4.32e-03 9.66e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 9.82e-01 4.23e-03 9.93e-01
EML4 and NUDC in mitotic spindle formation 95 9.43e-01 -4.22e-03 9.71e-01
CD28 co-stimulation 33 9.69e-01 3.90e-03 9.85e-01
Resolution of Sister Chromatid Cohesion 104 9.47e-01 -3.74e-03 9.73e-01
HSF1-dependent transactivation 29 9.74e-01 -3.50e-03 9.88e-01
IRS-mediated signalling 34 9.73e-01 -3.37e-03 9.87e-01
SHC-mediated cascade:FGFR4 10 9.86e-01 -3.25e-03 9.95e-01
Fertilization 12 9.85e-01 -3.12e-03 9.95e-01
Nicotinamide salvaging 14 9.84e-01 3.09e-03 9.94e-01
Interferon alpha/beta signaling 57 9.68e-01 3.08e-03 9.85e-01
Signaling by Retinoic Acid 31 9.79e-01 2.78e-03 9.92e-01
Protein localization 157 9.57e-01 -2.47e-03 9.78e-01
Metabolism of water-soluble vitamins and cofactors 109 9.70e-01 -2.05e-03 9.86e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 9.82e-01 -1.96e-03 9.93e-01
NoRC negatively regulates rRNA expression 62 9.88e-01 1.08e-03 9.96e-01
TICAM1-dependent activation of IRF3/IRF7 12 9.95e-01 -9.94e-04 1.00e+00
Infectious disease 723 9.67e-01 -8.93e-04 9.85e-01
AURKA Activation by TPX2 72 9.90e-01 8.54e-04 9.97e-01
Cytosolic sensors of pathogen-associated DNA 62 9.95e-01 -4.53e-04 1.00e+00
Deactivation of the beta-catenin transactivating complex 36 9.98e-01 -2.57e-04 1.00e+00
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 9.99e-01 2.21e-04 1.00e+00
HIV Transcription Initiation 45 1.00e+00 -4.12e-06 1.00e+00
RNA Polymerase II HIV Promoter Escape 45 1.00e+00 -4.12e-06 1.00e+00
RNA Polymerase II Promoter Escape 45 1.00e+00 -4.12e-06 1.00e+00
RNA Polymerase II Transcription Initiation 45 1.00e+00 -4.12e-06 1.00e+00
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 1.00e+00 -4.12e-06 1.00e+00
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 1.00e+00 -4.12e-06 1.00e+00


Detailed Gene set reports



IRAK4 deficiency (TLR2/4)

511
set IRAK4 deficiency (TLR2/4)
setSize 10
pANOVA 1.74e-06
s.dist 0.873
p.adjustANOVA 2.19e-05



Top enriched genes

GeneID Gene Rank
MYD88 11089.5
CD36 10838.5
BTK 10811.5
TLR2 10436.5
TLR4 9795.5
TLR1 9684.5
LY96 9679.5
CD14 9281.5
TIRAP 8635.5
TLR6 8611.5

Click HERE to show all gene set members

GeneID Gene Rank
MYD88 11089.5
CD36 10838.5
BTK 10811.5
TLR2 10436.5
TLR4 9795.5
TLR1 9684.5
LY96 9679.5
CD14 9281.5
TIRAP 8635.5
TLR6 8611.5


MyD88 deficiency (TLR2/4)

684
set MyD88 deficiency (TLR2/4)
setSize 10
pANOVA 1.74e-06
s.dist 0.873
p.adjustANOVA 2.19e-05



Top enriched genes

GeneID Gene Rank
MYD88 11089.5
CD36 10838.5
BTK 10811.5
TLR2 10436.5
TLR4 9795.5
TLR1 9684.5
LY96 9679.5
CD14 9281.5
TIRAP 8635.5
TLR6 8611.5

Click HERE to show all gene set members

GeneID Gene Rank
MYD88 11089.5
CD36 10838.5
BTK 10811.5
TLR2 10436.5
TLR4 9795.5
TLR1 9684.5
LY96 9679.5
CD14 9281.5
TIRAP 8635.5
TLR6 8611.5


alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

1328
set alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize 12
pANOVA 4.98e-06
s.dist 0.761
p.adjustANOVA 5.42e-05



Top enriched genes

GeneID Gene Rank
ACSL1 10880.5
ACAA1 10644.5
FADS1 10420.5
ACOT8 10232.5
ACOX1 9962.5
ELOVL3 9726.5
ELOVL1 9667.5
HSD17B4 9289.5
ABCD1 8518.5
FADS2 7257.5
ELOVL5 5237.5
SCP2 2257.5

Click HERE to show all gene set members

GeneID Gene Rank
ACSL1 10880.5
ACAA1 10644.5
FADS1 10420.5
ACOT8 10232.5
ACOX1 9962.5
ELOVL3 9726.5
ELOVL1 9667.5
HSD17B4 9289.5
ABCD1 8518.5
FADS2 7257.5
ELOVL5 5237.5
SCP2 2257.5


alpha-linolenic acid (ALA) metabolism

1329
set alpha-linolenic acid (ALA) metabolism
setSize 12
pANOVA 4.98e-06
s.dist 0.761
p.adjustANOVA 5.42e-05



Top enriched genes

GeneID Gene Rank
ACSL1 10880.5
ACAA1 10644.5
FADS1 10420.5
ACOT8 10232.5
ACOX1 9962.5
ELOVL3 9726.5
ELOVL1 9667.5
HSD17B4 9289.5
ABCD1 8518.5
FADS2 7257.5
ELOVL5 5237.5
SCP2 2257.5

Click HERE to show all gene set members

GeneID Gene Rank
ACSL1 10880.5
ACAA1 10644.5
FADS1 10420.5
ACOT8 10232.5
ACOX1 9962.5
ELOVL3 9726.5
ELOVL1 9667.5
HSD17B4 9289.5
ABCD1 8518.5
FADS2 7257.5
ELOVL5 5237.5
SCP2 2257.5


Translocation of ZAP-70 to Immunological synapse

1276
set Translocation of ZAP-70 to Immunological synapse
setSize 24
pANOVA 3.58e-10
s.dist -0.739
p.adjustANOVA 9.19e-09



Top enriched genes

GeneID Gene Rank
TRAV8-4 -10257.5
TRBV12-3 -10110.5
TRAC -9976.5
LCK -9969.5
HLA-DQB2 -9765.5
CD3E -9683.5
TRBC1 -9672.5
TRAV29DV5 -9648.5
ZAP70 -9193.5
HLA-DRA -9153.5
TRAV19 -9034.5
CD3D -8924.5
CD3G -8688.5
CD247 -8683.5
HLA-DPB1 -8545.5
HLA-DPA1 -8407.5
TRBV7-9 -8392.5
HLA-DQA2 -8104.5
HLA-DQA1 -8089.5
CD4 -7093.5

Click HERE to show all gene set members

GeneID Gene Rank
TRAV8-4 -10257.5
TRBV12-3 -10110.5
TRAC -9976.5
LCK -9969.5
HLA-DQB2 -9765.5
CD3E -9683.5
TRBC1 -9672.5
TRAV29DV5 -9648.5
ZAP70 -9193.5
HLA-DRA -9153.5
TRAV19 -9034.5
CD3D -8924.5
CD3G -8688.5
CD247 -8683.5
HLA-DPB1 -8545.5
HLA-DPA1 -8407.5
TRBV7-9 -8392.5
HLA-DQA2 -8104.5
HLA-DQA1 -8089.5
CD4 -7093.5
HLA-DQB1 -6039.5
HLA-DRB1 -1229.5
HLA-DRB5 929.5
PTPN22 6832.5


Peptide chain elongation

806
set Peptide chain elongation
setSize 88
pANOVA 1.45e-30
s.dist -0.708
p.adjustANOVA 1.97e-28



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
EEF1A1 -9507.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
EEF1A1 -9507.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
EEF2 -5381.5
RPL36AL -4244.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
RPL39L -2073.5
RPS26 -1562.5
RPS27L 1022.5
RPS9 3524.5
RPL3L 4102.5
RPL26L1 6687.5
RPS4Y1 10357.5


Eukaryotic Translation Elongation

349
set Eukaryotic Translation Elongation
setSize 93
pANOVA 7.2e-32
s.dist -0.704
p.adjustANOVA 1.22e-29



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
EEF1A1 -9507.5
EEF1B2 -9470.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
EEF1A1 -9507.5
EEF1B2 -9470.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
EEF1G -8877.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
EEF1A1P5 -6527.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
EEF1D -5725.5
RPS24 -5521.5
EEF2 -5381.5
RPL36AL -4244.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
RPL39L -2073.5
RPS26 -1562.5
EEF1A2 -1205.5
RPS27L 1022.5
RPS9 3524.5
RPL3L 4102.5
RPL26L1 6687.5
RPS4Y1 10357.5


Selenocysteine synthesis

1058
set Selenocysteine synthesis
setSize 92
pANOVA 3.34e-30
s.dist -0.688
p.adjustANOVA 4.13e-28



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
SEPSECS -7967.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
SECISBP2 -7438.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
PSTK -6621.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
EEFSEC -5730.5
RPS24 -5521.5
SARS1 -4340.5
RPL36AL -4244.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
RPL39L -2073.5
RPS26 -1562.5
RPS27L 1022.5
RPS9 3524.5
RPL3L 4102.5
RPL26L1 6687.5
SEPHS2 8295.5
RPS4Y1 10357.5


Viral mRNA Translation

1313
set Viral mRNA Translation
setSize 88
pANOVA 1.86e-28
s.dist -0.681
p.adjustANOVA 1.81e-26



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
RPL36AL -4244.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
RPL39L -2073.5
RPS26 -1562.5
GRSF1 109.5
RPS27L 1022.5
RPS9 3524.5
RPL3L 4102.5
RPL26L1 6687.5
DNAJC3 9884.5
RPS4Y1 10357.5


Regulation of TLR by endogenous ligand

966
set Regulation of TLR by endogenous ligand
setSize 11
pANOVA 0.000108
s.dist 0.674
p.adjustANOVA 0.000776



Top enriched genes

GeneID Gene Rank
S100A8 11035.5
CD36 10838.5
S100A9 10452.5
TLR2 10436.5
TLR4 9795.5
TLR1 9684.5
LY96 9679.5
CD14 9281.5
TLR6 8611.5
S100A1 -909.5
HMGB1 -3833.5

Click HERE to show all gene set members

GeneID Gene Rank
S100A8 11035.5
CD36 10838.5
S100A9 10452.5
TLR2 10436.5
TLR4 9795.5
TLR1 9684.5
LY96 9679.5
CD14 9281.5
TLR6 8611.5
S100A1 -909.5
HMGB1 -3833.5


Eukaryotic Translation Termination

351
set Eukaryotic Translation Termination
setSize 92
pANOVA 6.71e-29
s.dist -0.672
p.adjustANOVA 7.03e-27



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
N6AMT1 -9939.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
N6AMT1 -9939.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
GSPT2 -8663.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
RPL36AL -4244.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
TRMT112 -2639.5
RPL39L -2073.5
RPS26 -1562.5
GSPT1 -471.5
RPS27L 1022.5
RPS9 3524.5
RPL3L 4102.5
APEH 5603.5
RPL26L1 6687.5
ETF1 8012.5
RPS4Y1 10357.5


Formation of a pool of free 40S subunits

391
set Formation of a pool of free 40S subunits
setSize 100
pANOVA 5.5e-31
s.dist -0.669
p.adjustANOVA 8.31e-29



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
EIF3E -7948.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
EIF3L -6949.5
RPSA -6911.5
EIF1AX -6840.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
EIF3H -4791.5
EIF3F -4537.5
RPL36AL -4244.5
EIF3M -4192.5
EIF3D -4128.5
EIF3J -3884.5
EIF3C -3345.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
EIF3G -2092.5
RPL39L -2073.5
RPS26 -1562.5
EIF3K -1069.5
EIF3I -600.5
EIF3A 820.5
RPS27L 1022.5
RPS9 3524.5
RPL3L 4102.5
RPL26L1 6687.5
RPS4Y1 10357.5


Hyaluronan uptake and degradation

503
set Hyaluronan uptake and degradation
setSize 12
pANOVA 8.49e-05
s.dist 0.655
p.adjustANOVA 0.000646



Top enriched genes

GeneID Gene Rank
GUSB 11056.5
SLC9A1 11053.5
HYAL2 11038.5
LYVE1 10594.5
CHP1 10425.5
CD44 9541.5
HEXB 8878.5
HYAL1 8124.5
HMMR 4850.5
STAB2 3610.5
HYAL3 2047.5
HEXA -861.5

Click HERE to show all gene set members

GeneID Gene Rank
GUSB 11056.5
SLC9A1 11053.5
HYAL2 11038.5
LYVE1 10594.5
CHP1 10425.5
CD44 9541.5
HEXB 8878.5
HYAL1 8124.5
HMMR 4850.5
STAB2 3610.5
HYAL3 2047.5
HEXA -861.5


WNT5A-dependent internalization of FZD2, FZD5 and ROR2

1321
set WNT5A-dependent internalization of FZD2, FZD5 and ROR2
setSize 11
pANOVA 0.000172
s.dist 0.654
p.adjustANOVA 0.00113



Top enriched genes

GeneID Gene Rank
FZD5 11210.5
AP2A1 11164.5
CLTC 10405.5
AP2A2 9427.5
AP2M1 9313.5
AP2S1 8776.5
CLTB 8455.5
CLTA 8425.5
FZD2 5103.5
AP2B1 2793.5
ROR1 -2366.5

Click HERE to show all gene set members

GeneID Gene Rank
FZD5 11210.5
AP2A1 11164.5
CLTC 10405.5
AP2A2 9427.5
AP2M1 9313.5
AP2S1 8776.5
CLTB 8455.5
CLTA 8425.5
FZD2 5103.5
AP2B1 2793.5
ROR1 -2366.5


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

742
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 94
pANOVA 2.18e-27
s.dist -0.646
p.adjustANOVA 1.98e-25



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
NCBP2 -9768.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
NCBP2 -9768.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
GSPT2 -8663.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
RPL36AL -4244.5
FAU -3126.5
NCBP1 -3005.5
UBA52 -2832.5
RPL28 -2712.5
RPL39L -2073.5
RPS26 -1562.5
GSPT1 -471.5
PABPC1 172.5
RPS27L 1022.5
RPS9 3524.5
RPL3L 4102.5
RPL26L1 6687.5
UPF1 7864.5
ETF1 8012.5
RPS4Y1 10357.5
EIF4G1 10367.5


RHO GTPases Activate ROCKs

886
set RHO GTPases Activate ROCKs
setSize 18
pANOVA 2.75e-06
s.dist 0.638
p.adjustANOVA 3.23e-05



Top enriched genes

GeneID Gene Rank
MYL6 10203.5
CFL1 10009.5
RHOA 9999.5
PAK1 9764.5
ROCK1 9200.5
MYH9 9127.5
LIMK2 8705.5
PPP1R12A 8304.5
LIMK1 8202.5
RHOB 7592.5
PPP1CB 7543.5
ROCK2 7088.5
MYL12B 6905.5
MYH10 6214.5
RHOC 5884.5
MYL9 5525.5
PPP1R12B 5168.5
MYH11 -3227.5

Click HERE to show all gene set members

GeneID Gene Rank
MYL6 10203.5
CFL1 10009.5
RHOA 9999.5
PAK1 9764.5
ROCK1 9200.5
MYH9 9127.5
LIMK2 8705.5
PPP1R12A 8304.5
LIMK1 8202.5
RHOB 7592.5
PPP1CB 7543.5
ROCK2 7088.5
MYL12B 6905.5
MYH10 6214.5
RHOC 5884.5
MYL9 5525.5
PPP1R12B 5168.5
MYH11 -3227.5


Uptake and function of anthrax toxins

1304
set Uptake and function of anthrax toxins
setSize 10
pANOVA 0.000501
s.dist 0.635
p.adjustANOVA 0.00274



Top enriched genes

GeneID Gene Rank
MAP2K6 10813.5
FURIN 10794.5
MAP2K1 10453.5
MAP2K3 10316.5
PDCD6IP 8936.5
MAP2K4 7552.5
MAP2K2 7243.5
ANTXR2 6444.5
CALM1 782.5
MAP2K7 -156.5

Click HERE to show all gene set members

GeneID Gene Rank
MAP2K6 10813.5
FURIN 10794.5
MAP2K1 10453.5
MAP2K3 10316.5
PDCD6IP 8936.5
MAP2K4 7552.5
MAP2K2 7243.5
ANTXR2 6444.5
CALM1 782.5
MAP2K7 -156.5


MET activates RAP1 and RAC1

618
set MET activates RAP1 and RAC1
setSize 10
pANOVA 0.000566
s.dist 0.629
p.adjustANOVA 0.00307



Top enriched genes

GeneID Gene Rank
GRB2 10779.5
RAC1 10742.5
CRK 10400.5
HGF 10313.5
RAP1B 8483.5
RAP1A 8456.5
GAB1 8186.5
RAPGEF1 4702.5
CRKL 4324.5
DOCK7 -3856.5

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 10779.5
RAC1 10742.5
CRK 10400.5
HGF 10313.5
RAP1B 8483.5
RAP1A 8456.5
GAB1 8186.5
RAPGEF1 4702.5
CRKL 4324.5
DOCK7 -3856.5


VLDLR internalisation and degradation

1308
set VLDLR internalisation and degradation
setSize 12
pANOVA 0.000206
s.dist 0.619
p.adjustANOVA 0.00131



Top enriched genes

GeneID Gene Rank
AP2A1 11164.5
PCSK9 11032.5
CLTC 10405.5
AP2A2 9427.5
AP2M1 9313.5
NR1H2 9174.5
AP2S1 8776.5
CLTA 8425.5
VLDLR 5966.5
NR1H3 3412.5
AP2B1 2793.5
MYLIP -4263.5

Click HERE to show all gene set members

GeneID Gene Rank
AP2A1 11164.5
PCSK9 11032.5
CLTC 10405.5
AP2A2 9427.5
AP2M1 9313.5
NR1H2 9174.5
AP2S1 8776.5
CLTA 8425.5
VLDLR 5966.5
NR1H3 3412.5
AP2B1 2793.5
MYLIP -4263.5


NOTCH4 Activation and Transmission of Signal to the Nucleus

705
set NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize 10
pANOVA 0.000704
s.dist 0.619
p.adjustANOVA 0.00366



Top enriched genes

GeneID Gene Rank
NCSTN 11247.5
PSEN1 10429.5
ADAM10 10213.5
NOTCH4 9620.5
APH1B 9402.5
JAG1 8720.5
PSENEN 6991.5
YWHAZ 6774.5
APH1A 3859.5
PSEN2 -5897.5

Click HERE to show all gene set members

GeneID Gene Rank
NCSTN 11247.5
PSEN1 10429.5
ADAM10 10213.5
NOTCH4 9620.5
APH1B 9402.5
JAG1 8720.5
PSENEN 6991.5
YWHAZ 6774.5
APH1A 3859.5
PSEN2 -5897.5


Response of EIF2AK4 (GCN2) to amino acid deficiency

1006
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 100
pANOVA 9.85e-26
s.dist -0.606
p.adjustANOVA 6.71e-24



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
ASNS -7829.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
GCN1 -6953.5
RPSA -6911.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
IMPACT -4548.5
RPL36AL -4244.5
ATF3 -3181.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
RPL39L -2073.5
ATF2 -1817.5
RPS26 -1562.5
EIF2S1 226.5
TRIB3 622.5
EIF2AK4 842.5
RPS27L 1022.5
ATF4 1411.5
RPS9 3524.5
RPL3L 4102.5
EIF2S2 4457.5
DDIT3 4679.5
EIF2S3 4893.5
CEBPG 5065.5
RPL26L1 6687.5
RPS4Y1 10357.5
CEBPB 10866.5


Platelet sensitization by LDL

831
set Platelet sensitization by LDL
setSize 16
pANOVA 3.81e-05
s.dist 0.595
p.adjustANOVA 0.000329



Top enriched genes

GeneID Gene Rank
FGR 11143.5
MAPK14 10886.5
PECAM1 10467.5
PTPN6 10055.5
PLA2G4A 9955.5
PPP2R5A 9518.5
PPP2R5B 8818.5
LRP8 8762.5
PPP2CB 8306.5
PPP2CA 7872.5
PTPN11 7102.5
PPP2R5D 6173.5
PPP2R1A 5497.5
PPP2R5E -12.5
PPP2R1B -79.5
PPP2R5C -4477.5

Click HERE to show all gene set members

GeneID Gene Rank
FGR 11143.5
MAPK14 10886.5
PECAM1 10467.5
PTPN6 10055.5
PLA2G4A 9955.5
PPP2R5A 9518.5
PPP2R5B 8818.5
LRP8 8762.5
PPP2CB 8306.5
PPP2CA 7872.5
PTPN11 7102.5
PPP2R5D 6173.5
PPP2R1A 5497.5
PPP2R5E -12.5
PPP2R1B -79.5
PPP2R5C -4477.5


PD-1 signaling

777
set PD-1 signaling
setSize 28
pANOVA 5.11e-08
s.dist -0.595
p.adjustANOVA 9.28e-07



Top enriched genes

GeneID Gene Rank
TRAV8-4 -10257.5
TRBV12-3 -10110.5
TRAC -9976.5
LCK -9969.5
HLA-DQB2 -9765.5
CD3E -9683.5
TRBC1 -9672.5
TRAV29DV5 -9648.5
HLA-DRA -9153.5
TRAV19 -9034.5
CD3D -8924.5
CD274 -8820.5
CD3G -8688.5
CD247 -8683.5
HLA-DPB1 -8545.5
HLA-DPA1 -8407.5
TRBV7-9 -8392.5
HLA-DQA2 -8104.5
HLA-DQA1 -8089.5
CD4 -7093.5

Click HERE to show all gene set members

GeneID Gene Rank
TRAV8-4 -10257.5
TRBV12-3 -10110.5
TRAC -9976.5
LCK -9969.5
HLA-DQB2 -9765.5
CD3E -9683.5
TRBC1 -9672.5
TRAV29DV5 -9648.5
HLA-DRA -9153.5
TRAV19 -9034.5
CD3D -8924.5
CD274 -8820.5
CD3G -8688.5
CD247 -8683.5
HLA-DPB1 -8545.5
HLA-DPA1 -8407.5
TRBV7-9 -8392.5
HLA-DQA2 -8104.5
HLA-DQA1 -8089.5
CD4 -7093.5
HLA-DQB1 -6039.5
PDCD1 -4328.5
PDCD1LG2 -1671.5
HLA-DRB1 -1229.5
HLA-DRB5 929.5
PTPN11 7102.5
CSK 8938.5
PTPN6 10055.5


L13a-mediated translational silencing of Ceruloplasmin expression

587
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 110
pANOVA 4.86e-27
s.dist -0.594
p.adjustANOVA 4.14e-25



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
EIF4A2 -9973.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPL4 -9156.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
EIF4A2 -9973.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
EIF3E -7948.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
EIF4B -6960.5
RPL13 -6954.5
EIF3L -6949.5
RPSA -6911.5
EIF1AX -6840.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
EIF3H -4791.5
EIF3F -4537.5
RPL36AL -4244.5
EIF3M -4192.5
EIF3D -4128.5
EIF3J -3884.5
EIF3C -3345.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
EIF3G -2092.5
RPL39L -2073.5
RPS26 -1562.5
EIF3K -1069.5
EIF3I -600.5
PABPC1 172.5
EIF2S1 226.5
EIF3A 820.5
RPS27L 1022.5
EIF4E 3469.5
RPS9 3524.5
RPL3L 4102.5
EIF2S2 4457.5
EIF2S3 4893.5
RPL26L1 6687.5
EIF4A1 6944.5
EIF4H 8414.5
RPS4Y1 10357.5
EIF4G1 10367.5


GTP hydrolysis and joining of the 60S ribosomal subunit

433
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 111
pANOVA 5.73e-27
s.dist -0.59
p.adjustANOVA 4.59e-25



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
EIF4A2 -9973.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPL4 -9156.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
EIF4A2 -9973.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
EIF3E -7948.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
EIF4B -6960.5
RPL13 -6954.5
EIF3L -6949.5
RPSA -6911.5
EIF1AX -6840.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
EIF3H -4791.5
EIF3F -4537.5
EIF5B -4436.5
RPL36AL -4244.5
EIF3M -4192.5
EIF3D -4128.5
EIF3J -3884.5
EIF3C -3345.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
EIF3G -2092.5
RPL39L -2073.5
RPS26 -1562.5
EIF3K -1069.5
EIF3I -600.5
EIF2S1 226.5
EIF3A 820.5
RPS27L 1022.5
EIF5 2874.5
EIF4E 3469.5
RPS9 3524.5
RPL3L 4102.5
EIF2S2 4457.5
EIF2S3 4893.5
RPL26L1 6687.5
EIF4A1 6944.5
EIF4H 8414.5
RPS4Y1 10357.5
EIF4G1 10367.5


Major pathway of rRNA processing in the nucleolus and cytosol

624
set Major pathway of rRNA processing in the nucleolus and cytosol
setSize 180
pANOVA 6.36e-42
s.dist -0.585
p.adjustANOVA 1.73e-39



Top enriched genes

GeneID Gene Rank
RPP40 -10234.5
NOL11 -10195.5
NOP58 -10172.5
GNL3 -10132.5
WDR75 -10118.5
RPL23A -10081.5
EXOSC2 -10068.5
FBL -10040.5
TSR1 -10013.5
RPL3 -9996.5
UTP4 -9956.5
LAS1L -9928.5
RPL5 -9919.5
NOP56 -9879.5
BMS1 -9863.5
NOP14 -9862.5
RPL14 -9806.5
DDX47 -9767.5
EXOSC8 -9732.5
RPS27A -9724.5

Click HERE to show all gene set members

GeneID Gene Rank
RPP40 -10234.5
NOL11 -10195.5
NOP58 -10172.5
GNL3 -10132.5
WDR75 -10118.5
RPL23A -10081.5
EXOSC2 -10068.5
FBL -10040.5
TSR1 -10013.5
RPL3 -9996.5
UTP4 -9956.5
LAS1L -9928.5
RPL5 -9919.5
NOP56 -9879.5
BMS1 -9863.5
NOP14 -9862.5
RPL14 -9806.5
DDX47 -9767.5
EXOSC8 -9732.5
RPS27A -9724.5
RPS25 -9690.5
WDR43 -9680.5
RPS3A -9656.5
RPS6 -9628.5
UTP15 -9513.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
NOL9 -9222.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
WDR46 -9028.5
NCL -8982.5
PELP1 -8975.5
RPS4X -8943.5
TEX10 -8917.5
RPL12 -8913.5
EMG1 -8892.5
RPS29 -8844.5
RPL35A -8833.5
RRP9 -8813.5
RPL30 -8765.5
NOB1 -8737.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
EXOSC5 -8667.5
RPS15A -8665.5
NOL6 -8644.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
MPHOSPH10 -8503.5
RPLP0 -8498.5
RPL17 -8493.5
RPP38 -8481.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPP25 -8297.5
RPP30 -8296.5
RPL29 -8292.5
IMP4 -8278.5
EXOSC9 -8274.5
EXOSC7 -8273.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
UTP6 -8227.5
UTP20 -8211.5
KRR1 -8164.5
HEATR1 -8151.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
SNU13 -8035.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
IMP3 -7579.5
EXOSC10 -7526.5
RPL37 -7436.5
WDR3 -7431.5
RPL9 -7396.5
CSNK1E -7322.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
LTV1 -7230.5
RCL1 -7206.5
RPL27 -7182.5
RIOK2 -7137.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
NIP7 -6865.5
PDCD11 -6779.5
RPL35 -6772.5
RBM28 -6708.5
EBNA1BP2 -6646.5
PNO1 -6631.5
RPL22L1 -6495.5
BOP1 -6239.5
RPL37A -6190.5
DCAF13 -6185.5
RPS15 -6115.5
WDR36 -5888.5
RPL8 -5879.5
RPLP1 -5853.5
BYSL -5835.5
DHX37 -5552.5
RPS24 -5521.5
RPP21 -5390.5
EXOSC6 -5356.5
RIOK1 -5193.5
PES1 -5112.5
UTP3 -4302.5
RPL36AL -4244.5
MTREX -3800.5
RRP7A -3749.5
DIS3 -3640.5
WDR18 -3274.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
RRP1 -2673.5
RPL39L -2073.5
RPS26 -1562.5
UTP14A -1124.5
SENP3 -1016.5
MPHOSPH6 -676.5
TBL3 -622.5
PWP2 -540.5
EXOSC3 -346.5
FTSJ3 132.5
EXOSC1 326.5
RPP14 345.5
RPS27L 1022.5
UTP14C 1112.5
WDR12 1391.5
DDX21 1488.5
NOC4L 1553.5
C1D 2185.5
RRP36 2394.5
UTP11 2458.5
DDX52 2729.5
NOL12 2858.5
FCF1 2987.5
RPS9 3524.5
UTP18 3945.5
RPL3L 4102.5
DDX49 4169.5
ISG20L2 4625.5
RPL26L1 6687.5
CSNK1D 7071.5
ERI1 7141.5
RIOK3 7925.5
SNORD3A 9522.5
EXOSC4 9870.5
XRN2 10326.5
RPS4Y1 10357.5


rRNA processing in the nucleus and cytosol

1353
set rRNA processing in the nucleus and cytosol
setSize 190
pANOVA 1.07e-43
s.dist -0.582
p.adjustANOVA 4.84e-41



Top enriched genes

GeneID Gene Rank
DKC1 -10347.5
RPP40 -10234.5
NOL11 -10195.5
NOP58 -10172.5
GNL3 -10132.5
NAT10 -10127.5
WDR75 -10118.5
RPL23A -10081.5
EXOSC2 -10068.5
FBL -10040.5
TSR1 -10013.5
THUMPD1 -9997.5
RPL3 -9996.5
UTP4 -9956.5
LAS1L -9928.5
RPL5 -9919.5
NOP56 -9879.5
BMS1 -9863.5
NOP14 -9862.5
RPL14 -9806.5

Click HERE to show all gene set members

GeneID Gene Rank
DKC1 -10347.5
RPP40 -10234.5
NOL11 -10195.5
NOP58 -10172.5
GNL3 -10132.5
NAT10 -10127.5
WDR75 -10118.5
RPL23A -10081.5
EXOSC2 -10068.5
FBL -10040.5
TSR1 -10013.5
THUMPD1 -9997.5
RPL3 -9996.5
UTP4 -9956.5
LAS1L -9928.5
RPL5 -9919.5
NOP56 -9879.5
BMS1 -9863.5
NOP14 -9862.5
RPL14 -9806.5
DDX47 -9767.5
EXOSC8 -9732.5
RPS27A -9724.5
RPS25 -9690.5
WDR43 -9680.5
RPS3A -9656.5
RPS6 -9628.5
UTP15 -9513.5
DIMT1 -9455.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
NOL9 -9222.5
NOP2 -9214.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
WDR46 -9028.5
NCL -8982.5
PELP1 -8975.5
RPS4X -8943.5
TEX10 -8917.5
RPL12 -8913.5
EMG1 -8892.5
RPS29 -8844.5
RPL35A -8833.5
RRP9 -8813.5
RPL30 -8765.5
NOB1 -8737.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
EXOSC5 -8667.5
RPS15A -8665.5
NOL6 -8644.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
MPHOSPH10 -8503.5
RPLP0 -8498.5
RPL17 -8493.5
RPP38 -8481.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPP25 -8297.5
RPP30 -8296.5
RPL29 -8292.5
IMP4 -8278.5
EXOSC9 -8274.5
EXOSC7 -8273.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
UTP6 -8227.5
UTP20 -8211.5
KRR1 -8164.5
HEATR1 -8151.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
SNU13 -8035.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
IMP3 -7579.5
EXOSC10 -7526.5
RPL37 -7436.5
WDR3 -7431.5
RPL9 -7396.5
CSNK1E -7322.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
LTV1 -7230.5
RCL1 -7206.5
RPL27 -7182.5
RIOK2 -7137.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
NIP7 -6865.5
PDCD11 -6779.5
RPL35 -6772.5
GAR1 -6757.5
RBM28 -6708.5
EBNA1BP2 -6646.5
PNO1 -6631.5
RPL22L1 -6495.5
NHP2 -6395.5
BOP1 -6239.5
RPL37A -6190.5
DCAF13 -6185.5
RPS15 -6115.5
WDR36 -5888.5
RPL8 -5879.5
RPLP1 -5853.5
BYSL -5835.5
DHX37 -5552.5
RPS24 -5521.5
RPP21 -5390.5
EXOSC6 -5356.5
RIOK1 -5193.5
PES1 -5112.5
UTP3 -4302.5
RPL36AL -4244.5
MTREX -3800.5
RRP7A -3749.5
DIS3 -3640.5
WDR18 -3274.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
RRP1 -2673.5
TRMT112 -2639.5
RPL39L -2073.5
RPS26 -1562.5
UTP14A -1124.5
SENP3 -1016.5
MPHOSPH6 -676.5
TBL3 -622.5
PWP2 -540.5
EXOSC3 -346.5
FTSJ3 132.5
EXOSC1 326.5
RPP14 345.5
RPS27L 1022.5
UTP14C 1112.5
WDR12 1391.5
DDX21 1488.5
NOC4L 1553.5
C1D 2185.5
RRP36 2394.5
UTP11 2458.5
DDX52 2729.5
NOL12 2858.5
FCF1 2987.5
TSR3 3368.5
RPS9 3524.5
UTP18 3945.5
RPL3L 4102.5
DDX49 4169.5
ISG20L2 4625.5
RPL26L1 6687.5
CSNK1D 7071.5
ERI1 7141.5
RIOK3 7925.5
SNORD3A 9522.5
EXOSC4 9870.5
NOP10 10132.5
XRN2 10326.5
RPS4Y1 10357.5


Advanced glycosylation endproduct receptor signaling

60
set Advanced glycosylation endproduct receptor signaling
setSize 12
pANOVA 0.000612
s.dist 0.571
p.adjustANOVA 0.00328



Top enriched genes

GeneID Gene Rank
S100A12 11059.5
MAPK1 11021.5
CAPZA1 9842.5
LGALS3 9700.5
CAPZA2 9231.5
MAPK3 9113.5
DDOST 8871.5
APP 8091.5
PRKCSH 7196.5
AGER 2997.5
S100B -3826.5
HMGB1 -3833.5

Click HERE to show all gene set members

GeneID Gene Rank
S100A12 11059.5
MAPK1 11021.5
CAPZA1 9842.5
LGALS3 9700.5
CAPZA2 9231.5
MAPK3 9113.5
DDOST 8871.5
APP 8091.5
PRKCSH 7196.5
AGER 2997.5
S100B -3826.5
HMGB1 -3833.5


RHO GTPases Activate WASPs and WAVEs

887
set RHO GTPases Activate WASPs and WAVEs
setSize 35
pANOVA 4.96e-09
s.dist 0.571
p.adjustANOVA 1.11e-07



Top enriched genes

GeneID Gene Rank
NCKAP1L 11147.5
WASF1 11026.5
MAPK1 11021.5
ARPC1A 10888.5
BTK 10811.5
WASF2 10788.5
ARPC1B 10781.5
GRB2 10779.5
RAC1 10742.5
ACTB 10669.5
WAS 10446.5
ARPC5 10413.5
CYFIP1 10366.5
ARPC4 9841.5
ACTG1 9779.5
ACTR2 9514.5
ARPC2 9489.5
ABI1 9459.5
ARPC3 9433.5
NCKAP1 9307.5

Click HERE to show all gene set members

GeneID Gene Rank
NCKAP1L 11147.5
WASF1 11026.5
MAPK1 11021.5
ARPC1A 10888.5
BTK 10811.5
WASF2 10788.5
ARPC1B 10781.5
GRB2 10779.5
RAC1 10742.5
ACTB 10669.5
WAS 10446.5
ARPC5 10413.5
CYFIP1 10366.5
ARPC4 9841.5
ACTG1 9779.5
ACTR2 9514.5
ARPC2 9489.5
ABI1 9459.5
ARPC3 9433.5
NCKAP1 9307.5
ACTR3 9282.5
WIPF2 9236.5
MAPK3 9113.5
CDC42 9089.5
ABL1 5740.5
BRK1 3561.5
WIPF1 2706.5
WASF3 2704.5
WASL 1523.5
PTK2 -231.5
BAIAP2 -2739.5
CYFIP2 -3074.5
NCKIPSD -4465.5
ABI2 -8608.5
NCK1 -9045.5


Nucleobase biosynthesis

753
set Nucleobase biosynthesis
setSize 13
pANOVA 0.000395
s.dist -0.567
p.adjustANOVA 0.00226



Top enriched genes

GeneID Gene Rank
IMPDH2 -10331.5
ATIC -10284.5
PPAT -10253.5
UMPS -10151.5
PFAS -9873.5
PAICS -9714.5
CAD -9610.5
DHODH -6253.5
GMPS -4587.5
ADSL -4376.5
LHPP -3933.5
GART 4386.5
IMPDH1 11072.5

Click HERE to show all gene set members

GeneID Gene Rank
IMPDH2 -10331.5
ATIC -10284.5
PPAT -10253.5
UMPS -10151.5
PFAS -9873.5
PAICS -9714.5
CAD -9610.5
DHODH -6253.5
GMPS -4587.5
ADSL -4376.5
LHPP -3933.5
GART 4386.5
IMPDH1 11072.5


Selenoamino acid metabolism

1057
set Selenoamino acid metabolism
setSize 114
pANOVA 2.43e-25
s.dist -0.563
p.adjustANOVA 1.44e-23



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
LARS1 -9846.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
IARS1 -9630.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
LARS1 -9846.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
IARS1 -9630.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
AIMP1 -8457.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
SCLY -8146.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
SEPSECS -7967.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
SECISBP2 -7438.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
PSTK -6621.5
KARS1 -6596.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
EEFSEC -5730.5
RPS24 -5521.5
EPRS1 -4983.5
SARS1 -4340.5
RPL36AL -4244.5
DARS1 -4203.5
CTH -3392.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
INMT -2603.5
AHCY -2338.5
RARS1 -2336.5
QARS1 -2244.5
RPL39L -2073.5
RPS26 -1562.5
EEF1E1 -1413.5
AIMP2 -832.5
RPS27L 1022.5
GNMT 2447.5
RPS9 3524.5
RPL3L 4102.5
MARS1 4432.5
RPL26L1 6687.5
HNMT 7349.5
SEPHS2 8295.5
TXNRD1 9923.5
RPS4Y1 10357.5
PAPSS1 10470.5
CBS 10806.5
GSR 11015.5
PAPSS2 11108.5


Gap junction trafficking

435
set Gap junction trafficking
setSize 13
pANOVA 0.000449
s.dist 0.562
p.adjustANOVA 0.0025



Top enriched genes

GeneID Gene Rank
DAB2 10741.5
GJD3 10595.5
CLTC 10405.5
DNM2 9784.5
CLTCL1 9765.5
AP2M1 9313.5
CLTB 8455.5
CLTA 8425.5
DNM1 7143.5
GJC1 4667.5
GJB6 2579.5
GJC2 -3145.5
MYO6 -3914.5

Click HERE to show all gene set members

GeneID Gene Rank
DAB2 10741.5
GJD3 10595.5
CLTC 10405.5
DNM2 9784.5
CLTCL1 9765.5
AP2M1 9313.5
CLTB 8455.5
CLTA 8425.5
DNM1 7143.5
GJC1 4667.5
GJB6 2579.5
GJC2 -3145.5
MYO6 -3914.5


Formation of the ternary complex, and subsequently, the 43S complex

397
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 51
pANOVA 5.32e-12
s.dist -0.558
p.adjustANOVA 1.81e-10



Top enriched genes

GeneID Gene Rank
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPS27 -9326.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPS2 -9140.5
RPS5 -9136.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPS29 -8844.5
RPS15A -8665.5
RPS7 -8556.5
RPS16 -8540.5
RPS10 -8410.5
RPS18 -8405.5
RPS13 -8264.5

Click HERE to show all gene set members

GeneID Gene Rank
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPS27 -9326.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPS2 -9140.5
RPS5 -9136.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPS29 -8844.5
RPS15A -8665.5
RPS7 -8556.5
RPS16 -8540.5
RPS10 -8410.5
RPS18 -8405.5
RPS13 -8264.5
RPS8 -8088.5
RPS17 -8066.5
RPS28 -8017.5
RPS11 -8011.5
RPS21 -7997.5
EIF3E -7948.5
RPS14 -7901.5
RPS19 -7123.5
EIF3L -6949.5
RPSA -6911.5
EIF1AX -6840.5
RPS15 -6115.5
RPS24 -5521.5
EIF3H -4791.5
EIF3F -4537.5
EIF3M -4192.5
EIF3D -4128.5
EIF3J -3884.5
EIF3C -3345.5
FAU -3126.5
EIF3G -2092.5
RPS26 -1562.5
EIF3K -1069.5
EIF3I -600.5
EIF2S1 226.5
EIF3A 820.5
RPS27L 1022.5
RPS9 3524.5
EIF2S2 4457.5
EIF2S3 4893.5
RPS4Y1 10357.5


PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

799
set PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
setSize 13
pANOVA 5e-04
s.dist 0.558
p.adjustANOVA 0.00274



Top enriched genes

GeneID Gene Rank
RAC1 10742.5
CRK 10400.5
ELMO2 10099.5
RHOA 9999.5
PXN 9614.5
PTK6 8563.5
DOCK1 7819.5
KRAS 6511.5
NRAS 6317.5
ELMO1 5758.5
RASA1 5240.5
ARHGAP35 -870.5
HRAS -6026.5

Click HERE to show all gene set members

GeneID Gene Rank
RAC1 10742.5
CRK 10400.5
ELMO2 10099.5
RHOA 9999.5
PXN 9614.5
PTK6 8563.5
DOCK1 7819.5
KRAS 6511.5
NRAS 6317.5
ELMO1 5758.5
RASA1 5240.5
ARHGAP35 -870.5
HRAS -6026.5


RHO GTPases activate IQGAPs

889
set RHO GTPases activate IQGAPs
setSize 11
pANOVA 0.00137
s.dist 0.557
p.adjustANOVA 0.00634



Top enriched genes

GeneID Gene Rank
CTNNA1 11170.5
RAC1 10742.5
CLIP1 10593.5
IQGAP1 10093.5
IQGAP2 9320.5
CTNNB1 9148.5
CDC42 9089.5
IQGAP3 4886.5
CDH1 2204.5
CALM1 782.5
MEN1 -6825.5

Click HERE to show all gene set members

GeneID Gene Rank
CTNNA1 11170.5
RAC1 10742.5
CLIP1 10593.5
IQGAP1 10093.5
IQGAP2 9320.5
CTNNB1 9148.5
CDC42 9089.5
IQGAP3 4886.5
CDH1 2204.5
CALM1 782.5
MEN1 -6825.5


Cap-dependent Translation Initiation

142
set Cap-dependent Translation Initiation
setSize 118
pANOVA 1.43e-25
s.dist -0.556
p.adjustANOVA 8.87e-24



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
EIF4A2 -9973.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPL4 -9156.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
EIF4A2 -9973.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
EIF3E -7948.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
EIF4B -6960.5
RPL13 -6954.5
EIF3L -6949.5
RPSA -6911.5
EIF1AX -6840.5
RPL35 -6772.5
EIF2B5 -6551.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
EIF2B3 -5240.5
EIF3H -4791.5
EIF3F -4537.5
EIF5B -4436.5
RPL36AL -4244.5
EIF3M -4192.5
EIF3D -4128.5
EIF3J -3884.5
EIF3C -3345.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
EIF3G -2092.5
RPL39L -2073.5
EIF2B1 -2035.5
RPS26 -1562.5
EIF3K -1069.5
EIF3I -600.5
PABPC1 172.5
EIF2S1 226.5
EIF3A 820.5
RPS27L 1022.5
EIF5 2874.5
EIF4E 3469.5
RPS9 3524.5
EIF2B4 3542.5
RPL3L 4102.5
EIF2S2 4457.5
EIF4EBP1 4569.5
EIF2S3 4893.5
RPL26L1 6687.5
EIF4A1 6944.5
EIF2B2 7208.5
EIF4H 8414.5
RPS4Y1 10357.5
EIF4G1 10367.5


Eukaryotic Translation Initiation

350
set Eukaryotic Translation Initiation
setSize 118
pANOVA 1.43e-25
s.dist -0.556
p.adjustANOVA 8.87e-24



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
EIF4A2 -9973.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPL4 -9156.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
EIF4A2 -9973.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
EIF3E -7948.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
EIF4B -6960.5
RPL13 -6954.5
EIF3L -6949.5
RPSA -6911.5
EIF1AX -6840.5
RPL35 -6772.5
EIF2B5 -6551.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
EIF2B3 -5240.5
EIF3H -4791.5
EIF3F -4537.5
EIF5B -4436.5
RPL36AL -4244.5
EIF3M -4192.5
EIF3D -4128.5
EIF3J -3884.5
EIF3C -3345.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
EIF3G -2092.5
RPL39L -2073.5
EIF2B1 -2035.5
RPS26 -1562.5
EIF3K -1069.5
EIF3I -600.5
PABPC1 172.5
EIF2S1 226.5
EIF3A 820.5
RPS27L 1022.5
EIF5 2874.5
EIF4E 3469.5
RPS9 3524.5
EIF2B4 3542.5
RPL3L 4102.5
EIF2S2 4457.5
EIF4EBP1 4569.5
EIF2S3 4893.5
RPL26L1 6687.5
EIF4A1 6944.5
EIF2B2 7208.5
EIF4H 8414.5
RPS4Y1 10357.5
EIF4G1 10367.5


Retrograde neurotrophin signalling

1010
set Retrograde neurotrophin signalling
setSize 12
pANOVA 0.000897
s.dist 0.554
p.adjustANOVA 0.00451



Top enriched genes

GeneID Gene Rank
AP2A1 11164.5
CLTC 10405.5
DNM2 9784.5
AP2A2 9427.5
AP2M1 9313.5
AP2S1 8776.5
CLTA 8425.5
DNM1 7143.5
DNM3 6241.5
AP2B1 2793.5
DNAL4 -1080.5
NTRK1 -5203.5

Click HERE to show all gene set members

GeneID Gene Rank
AP2A1 11164.5
CLTC 10405.5
DNM2 9784.5
AP2A2 9427.5
AP2M1 9313.5
AP2S1 8776.5
CLTA 8425.5
DNM1 7143.5
DNM3 6241.5
AP2B1 2793.5
DNAL4 -1080.5
NTRK1 -5203.5


Activation of the pre-replicative complex

50
set Activation of the pre-replicative complex
setSize 32
pANOVA 8.06e-08
s.dist -0.548
p.adjustANOVA 1.37e-06



Top enriched genes

GeneID Gene Rank
MCM3 -10019.5
POLA1 -9998.5
RPA1 -9890.5
MCM7 -9735.5
PRIM1 -9380.5
POLE3 -9063.5
RPA3 -8957.5
ORC5 -8775.5
ORC2 -8711.5
DBF4 -8549.5
ORC3 -8240.5
POLA2 -7994.5
MCM6 -7548.5
POLE2 -7251.5
MCM4 -6477.5
PRIM2 -6460.5
MCM8 -6280.5
MCM2 -6252.5
ORC4 -5885.5
POLE -5330.5

Click HERE to show all gene set members

GeneID Gene Rank
MCM3 -10019.5
POLA1 -9998.5
RPA1 -9890.5
MCM7 -9735.5
PRIM1 -9380.5
POLE3 -9063.5
RPA3 -8957.5
ORC5 -8775.5
ORC2 -8711.5
DBF4 -8549.5
ORC3 -8240.5
POLA2 -7994.5
MCM6 -7548.5
POLE2 -7251.5
MCM4 -6477.5
PRIM2 -6460.5
MCM8 -6280.5
MCM2 -6252.5
ORC4 -5885.5
POLE -5330.5
CDC7 -4953.5
RPA2 -4279.5
CDK2 -4114.5
CDC45 -3940.5
MCM10 -3818.5
MCM5 -2276.5
ORC1 -633.5
CDT1 -412.5
CDC6 -226.5
POLE4 540.5
GMNN 2473.5
ORC6 7450.5


Signal transduction by L1

1070
set Signal transduction by L1
setSize 20
pANOVA 2.34e-05
s.dist 0.546
p.adjustANOVA 0.000213



Top enriched genes

GeneID Gene Rank
MAPK1 11021.5
RAC1 10742.5
MAP2K1 10453.5
PAK1 9764.5
ITGA5 9503.5
CSNK2A1 9432.5
MAPK3 9113.5
ITGA9 9012.5
ITGA2B 8575.5
CSNK2A2 7797.5
ITGAV 7510.5
MAP2K2 7243.5
FGFR1 6141.5
CSNK2B 5761.5
ITGB3 5547.5
NRP1 4114.5
VAV2 2301.5
ITGB1 -854.5
NCAM1 -2082.5
L1CAM -4098.5

Click HERE to show all gene set members

GeneID Gene Rank
MAPK1 11021.5
RAC1 10742.5
MAP2K1 10453.5
PAK1 9764.5
ITGA5 9503.5
CSNK2A1 9432.5
MAPK3 9113.5
ITGA9 9012.5
ITGA2B 8575.5
CSNK2A2 7797.5
ITGAV 7510.5
MAP2K2 7243.5
FGFR1 6141.5
CSNK2B 5761.5
ITGB3 5547.5
NRP1 4114.5
VAV2 2301.5
ITGB1 -854.5
NCAM1 -2082.5
L1CAM -4098.5


Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

344
set Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
setSize 11
pANOVA 0.00183
s.dist 0.543
p.adjustANOVA 0.00802



Top enriched genes

GeneID Gene Rank
LYN 10820.5
EPOR 10311.5
IRS2 9986.5
PIK3CB 9508.5
PIK3CG 9315.5
GAB1 8186.5
PIK3CD 7499.5
PIK3R5 5691.5
JAK2 3436.5
PIK3CA 2781.5
PIK3R1 -8072.5

Click HERE to show all gene set members

GeneID Gene Rank
LYN 10820.5
EPOR 10311.5
IRS2 9986.5
PIK3CB 9508.5
PIK3CG 9315.5
GAB1 8186.5
PIK3CD 7499.5
PIK3R5 5691.5
JAK2 3436.5
PIK3CA 2781.5
PIK3R1 -8072.5


rRNA modification in the nucleus and cytosol

1350
set rRNA modification in the nucleus and cytosol
setSize 59
pANOVA 6.36e-13
s.dist -0.541
p.adjustANOVA 2.55e-11



Top enriched genes

GeneID Gene Rank
DKC1 -10347.5
NOL11 -10195.5
NOP58 -10172.5
NAT10 -10127.5
WDR75 -10118.5
FBL -10040.5
THUMPD1 -9997.5
UTP4 -9956.5
NOP56 -9879.5
BMS1 -9863.5
NOP14 -9862.5
DDX47 -9767.5
WDR43 -9680.5
RPS6 -9628.5
UTP15 -9513.5
DIMT1 -9455.5
NOP2 -9214.5
RPS2 -9140.5
WDR46 -9028.5
EMG1 -8892.5

Click HERE to show all gene set members

GeneID Gene Rank
DKC1 -10347.5
NOL11 -10195.5
NOP58 -10172.5
NAT10 -10127.5
WDR75 -10118.5
FBL -10040.5
THUMPD1 -9997.5
UTP4 -9956.5
NOP56 -9879.5
BMS1 -9863.5
NOP14 -9862.5
DDX47 -9767.5
WDR43 -9680.5
RPS6 -9628.5
UTP15 -9513.5
DIMT1 -9455.5
NOP2 -9214.5
RPS2 -9140.5
WDR46 -9028.5
EMG1 -8892.5
RRP9 -8813.5
NOL6 -8644.5
RPS7 -8556.5
MPHOSPH10 -8503.5
IMP4 -8278.5
UTP6 -8227.5
UTP20 -8211.5
KRR1 -8164.5
HEATR1 -8151.5
SNU13 -8035.5
RPS14 -7901.5
IMP3 -7579.5
WDR3 -7431.5
RCL1 -7206.5
PDCD11 -6779.5
GAR1 -6757.5
PNO1 -6631.5
NHP2 -6395.5
DCAF13 -6185.5
WDR36 -5888.5
DHX37 -5552.5
UTP3 -4302.5
RRP7A -3749.5
TRMT112 -2639.5
UTP14A -1124.5
TBL3 -622.5
PWP2 -540.5
UTP14C 1112.5
NOC4L 1553.5
RRP36 2394.5
UTP11 2458.5
DDX52 2729.5
FCF1 2987.5
TSR3 3368.5
RPS9 3524.5
UTP18 3945.5
DDX49 4169.5
SNORD3A 9522.5
NOP10 10132.5


Unwinding of DNA

1302
set Unwinding of DNA
setSize 12
pANOVA 0.00117
s.dist -0.541
p.adjustANOVA 0.00564



Top enriched genes

GeneID Gene Rank
MCM3 -10019.5
MCM7 -9735.5
GINS4 -7791.5
MCM6 -7548.5
MCM4 -6477.5
MCM8 -6280.5
MCM2 -6252.5
GINS3 -5374.5
CDC45 -3940.5
MCM5 -2276.5
GINS2 -2066.5
GINS1 2963.5

Click HERE to show all gene set members

GeneID Gene Rank
MCM3 -10019.5
MCM7 -9735.5
GINS4 -7791.5
MCM6 -7548.5
MCM4 -6477.5
MCM8 -6280.5
MCM2 -6252.5
GINS3 -5374.5
CDC45 -3940.5
MCM5 -2276.5
GINS2 -2066.5
GINS1 2963.5


Processive synthesis on the lagging strand

858
set Processive synthesis on the lagging strand
setSize 15
pANOVA 0.000286
s.dist -0.541
p.adjustANOVA 0.0017



Top enriched genes

GeneID Gene Rank
POLD2 -10282.5
POLA1 -9998.5
LIG1 -9980.5
RPA1 -9890.5
PRIM1 -9380.5
RPA3 -8957.5
POLA2 -7994.5
PCNA -6647.5
PRIM2 -6460.5
FEN1 -5957.5
DNA2 -5899.5
POLD1 -4363.5
RPA2 -4279.5
POLD4 8406.5
POLD3 10715.5

Click HERE to show all gene set members

GeneID Gene Rank
POLD2 -10282.5
POLA1 -9998.5
LIG1 -9980.5
RPA1 -9890.5
PRIM1 -9380.5
RPA3 -8957.5
POLA2 -7994.5
PCNA -6647.5
PRIM2 -6460.5
FEN1 -5957.5
DNA2 -5899.5
POLD1 -4363.5
RPA2 -4279.5
POLD4 8406.5
POLD3 10715.5


Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

741
set Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize 114
pANOVA 4e-23
s.dist -0.536
p.adjustANOVA 2.1e-21



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
NCBP2 -9768.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
NCBP2 -9768.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
GSPT2 -8663.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
UPF3A -7996.5
MAGOHB -7962.5
RNPS1 -7920.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
UPF3B -4439.5
RPL36AL -4244.5
MAGOH -3652.5
DCP1A -3551.5
PNRC2 -3290.5
FAU -3126.5
NCBP1 -3005.5
UBA52 -2832.5
RPL28 -2712.5
SMG1 -2169.5
RPL39L -2073.5
RPS26 -1562.5
RBM8A -1327.5
SMG6 -1323.5
GSPT1 -471.5
PABPC1 172.5
RPS27L 1022.5
UPF2 1869.5
PPP2R2A 2090.5
SMG9 2103.5
EIF4A3 3127.5
RPS9 3524.5
SMG8 3897.5
RPL3L 4102.5
SMG5 4737.5
PPP2R1A 5497.5
RPL26L1 6687.5
UPF1 7864.5
PPP2CA 7872.5
ETF1 8012.5
CASC3 8434.5
SMG7 9224.5
RPS4Y1 10357.5
EIF4G1 10367.5


Nonsense-Mediated Decay (NMD)

743
set Nonsense-Mediated Decay (NMD)
setSize 114
pANOVA 4e-23
s.dist -0.536
p.adjustANOVA 2.1e-21



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
NCBP2 -9768.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
NCBP2 -9768.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
GSPT2 -8663.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
UPF3A -7996.5
MAGOHB -7962.5
RNPS1 -7920.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
UPF3B -4439.5
RPL36AL -4244.5
MAGOH -3652.5
DCP1A -3551.5
PNRC2 -3290.5
FAU -3126.5
NCBP1 -3005.5
UBA52 -2832.5
RPL28 -2712.5
SMG1 -2169.5
RPL39L -2073.5
RPS26 -1562.5
RBM8A -1327.5
SMG6 -1323.5
GSPT1 -471.5
PABPC1 172.5
RPS27L 1022.5
UPF2 1869.5
PPP2R2A 2090.5
SMG9 2103.5
EIF4A3 3127.5
RPS9 3524.5
SMG8 3897.5
RPL3L 4102.5
SMG5 4737.5
PPP2R1A 5497.5
RPL26L1 6687.5
UPF1 7864.5
PPP2CA 7872.5
ETF1 8012.5
CASC3 8434.5
SMG7 9224.5
RPS4Y1 10357.5
EIF4G1 10367.5


WNT5A-dependent internalization of FZD4

1322
set WNT5A-dependent internalization of FZD4
setSize 13
pANOVA 0.000838
s.dist 0.535
p.adjustANOVA 0.00427



Top enriched genes

GeneID Gene Rank
AP2A1 11164.5
ARRB2 10447.5
CLTC 10405.5
AP2A2 9427.5
AP2M1 9313.5
PRKCB 9176.5
AP2S1 8776.5
CLTB 8455.5
CLTA 8425.5
FZD4 3298.5
AP2B1 2793.5
PRKCA -3150.5
DVL2 -7537.5

Click HERE to show all gene set members

GeneID Gene Rank
AP2A1 11164.5
ARRB2 10447.5
CLTC 10405.5
AP2A2 9427.5
AP2M1 9313.5
PRKCB 9176.5
AP2S1 8776.5
CLTB 8455.5
CLTA 8425.5
FZD4 3298.5
AP2B1 2793.5
PRKCA -3150.5
DVL2 -7537.5


rRNA processing

1351
set rRNA processing
setSize 217
pANOVA 6.16e-42
s.dist -0.533
p.adjustANOVA 1.73e-39



Top enriched genes

GeneID Gene Rank
DKC1 -10347.5
RPP40 -10234.5
MTERF4 -10210.5
NOL11 -10195.5
NOP58 -10172.5
GNL3 -10132.5
NAT10 -10127.5
WDR75 -10118.5
RPL23A -10081.5
EXOSC2 -10068.5
FBL -10040.5
TSR1 -10013.5
THUMPD1 -9997.5
RPL3 -9996.5
UTP4 -9956.5
LAS1L -9928.5
RPL5 -9919.5
NOP56 -9879.5
BMS1 -9863.5
NOP14 -9862.5

Click HERE to show all gene set members

GeneID Gene Rank
DKC1 -10347.5
RPP40 -10234.5
MTERF4 -10210.5
NOL11 -10195.5
NOP58 -10172.5
GNL3 -10132.5
NAT10 -10127.5
WDR75 -10118.5
RPL23A -10081.5
EXOSC2 -10068.5
FBL -10040.5
TSR1 -10013.5
THUMPD1 -9997.5
RPL3 -9996.5
UTP4 -9956.5
LAS1L -9928.5
RPL5 -9919.5
NOP56 -9879.5
BMS1 -9863.5
NOP14 -9862.5
RPL14 -9806.5
DDX47 -9767.5
EXOSC8 -9732.5
RPS27A -9724.5
RPS25 -9690.5
WDR43 -9680.5
RPS3A -9656.5
RPS6 -9628.5
MRM1 -9613.5
UTP15 -9513.5
DIMT1 -9455.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
NOL9 -9222.5
NOP2 -9214.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
WDR46 -9028.5
NCL -8982.5
PELP1 -8975.5
RPS4X -8943.5
TEX10 -8917.5
RPL12 -8913.5
EMG1 -8892.5
RPS29 -8844.5
RPL35A -8833.5
RRP9 -8813.5
RPL30 -8765.5
NOB1 -8737.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
EXOSC5 -8667.5
RPS15A -8665.5
NOL6 -8644.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
MPHOSPH10 -8503.5
RPLP0 -8498.5
RPL17 -8493.5
RPP38 -8481.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPP25 -8297.5
RPP30 -8296.5
RPL29 -8292.5
IMP4 -8278.5
EXOSC9 -8274.5
EXOSC7 -8273.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
UTP6 -8227.5
UTP20 -8211.5
KRR1 -8164.5
HEATR1 -8151.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
SNU13 -8035.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
RPL23 -7793.5
TRMT10C -7756.5
RPL7A -7734.5
IMP3 -7579.5
EXOSC10 -7526.5
RPL37 -7436.5
WDR3 -7431.5
RPL9 -7396.5
CSNK1E -7322.5
RPL15 -7319.5
TFB1M -7275.5
RPL41 -7257.5
RPL38 -7234.5
LTV1 -7230.5
RCL1 -7206.5
RPL27 -7182.5
RIOK2 -7137.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
NIP7 -6865.5
PDCD11 -6779.5
RPL35 -6772.5
GAR1 -6757.5
RBM28 -6708.5
EBNA1BP2 -6646.5
PNO1 -6631.5
RPL22L1 -6495.5
NHP2 -6395.5
BOP1 -6239.5
RPL37A -6190.5
DCAF13 -6185.5
RPS15 -6115.5
WDR36 -5888.5
RPL8 -5879.5
RPLP1 -5853.5
BYSL -5835.5
DHX37 -5552.5
RPS24 -5521.5
RPP21 -5390.5
EXOSC6 -5356.5
RIOK1 -5193.5
PES1 -5112.5
ELAC2 -5098.5
MRM3 -5069.5
UTP3 -4302.5
RPL36AL -4244.5
MT-ND2 -4095.5
MT-ND1 -3858.5
MTREX -3800.5
RRP7A -3749.5
DIS3 -3640.5
MT-CO3 -3587.5
MT-ND3 -3556.5
MRM2 -3300.5
WDR18 -3274.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
RRP1 -2673.5
TRMT112 -2639.5
RPL39L -2073.5
MT-RNR1 -1829.5
RPS26 -1562.5
MT-CYB -1385.5
PRORP -1233.5
UTP14A -1124.5
MT-CO2 -1084.5
SENP3 -1016.5
MPHOSPH6 -676.5
TBL3 -622.5
MT-ND5 -548.5
PWP2 -540.5
MT-ATP6 -448.5
EXOSC3 -346.5
MT-CO1 89.5
FTSJ3 132.5
EXOSC1 326.5
RPP14 345.5
RPS27L 1022.5
UTP14C 1112.5
WDR12 1391.5
DDX21 1488.5
NOC4L 1553.5
MT-ND4L 2066.5
C1D 2185.5
MT-TV 2296.5
RRP36 2394.5
NSUN4 2441.5
UTP11 2458.5
MT-ATP8 2552.5
MT-RNR2 2618.5
DDX52 2729.5
MT-TF 2799.5
NOL12 2858.5
FCF1 2987.5
TSR3 3368.5
RPS9 3524.5
MT-ND4 3812.5
UTP18 3945.5
RPL3L 4102.5
DDX49 4169.5
MT-TL1 4480.5
ISG20L2 4625.5
HSD17B10 5028.5
RPL26L1 6687.5
CSNK1D 7071.5
ERI1 7141.5
RIOK3 7925.5
SNORD3A 9522.5
EXOSC4 9870.5
NOP10 10132.5
XRN2 10326.5
RPS4Y1 10357.5


Influenza Viral RNA Transcription and Replication

526
set Influenza Viral RNA Transcription and Replication
setSize 135
pANOVA 1.03e-26
s.dist -0.533
p.adjustANOVA 7.76e-25



Top enriched genes

GeneID Gene Rank
IPO5 -10318.5
NDC1 -10267.5
RPL23A -10081.5
NUP35 -10072.5
NUP88 -10035.5
RPL3 -9996.5
RPL5 -9919.5
SEH1L -9831.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5

Click HERE to show all gene set members

GeneID Gene Rank
IPO5 -10318.5
NDC1 -10267.5
RPL23A -10081.5
NUP35 -10072.5
NUP88 -10035.5
RPL3 -9996.5
RPL5 -9919.5
SEH1L -9831.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
NUP160 -9065.5
RPS12 -9042.5
PARP1 -9015.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
NUP188 -8637.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
NUP43 -8552.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
NUP205 -8276.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
NUP107 -8214.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
RPL23 -7793.5
RPL7A -7734.5
NUP54 -7606.5
NUP155 -7509.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
POLR2H -6977.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
POLR2D -5810.5
NUP133 -5672.5
RPS24 -5521.5
NUP93 -5318.5
NUP210 -5216.5
AAAS -4800.5
TPR -4491.5
RPL36AL -4244.5
POLR2I -3650.5
POLR2K -3481.5
NUP42 -3330.5
NUP85 -3271.5
FAU -3126.5
NUP62 -3092.5
POM121 -2842.5
UBA52 -2832.5
RPL28 -2712.5
POLR2B -2474.5
RPL39L -2073.5
RANBP2 -2053.5
HSP90AA1 -1986.5
NUP153 -1942.5
POM121C -1794.5
RPS26 -1562.5
POLR2C -1418.5
GRSF1 109.5
NUP37 369.5
RPS27L 1022.5
POLR2L 2259.5
RPS9 3524.5
RAE1 3714.5
NUP50 4037.5
NUP98 4046.5
RPL3L 4102.5
POLR2F 4110.5
POLR2G 4797.5
POLR2J 5259.5
POLR2E 6145.5
SEC13 6386.5
RPL26L1 6687.5
POLR2A 6928.5
GTF2F1 7017.5
GTF2F2 7096.5
NUP214 9446.5
NUP58 9569.5
DNAJC3 9884.5
RPS4Y1 10357.5


DNA strand elongation

245
set DNA strand elongation
setSize 32
pANOVA 2.09e-07
s.dist -0.53
p.adjustANOVA 3.28e-06



Top enriched genes

GeneID Gene Rank
POLD2 -10282.5
MCM3 -10019.5
POLA1 -9998.5
LIG1 -9980.5
RPA1 -9890.5
MCM7 -9735.5
RFC3 -9538.5
PRIM1 -9380.5
RFC4 -9363.5
RPA3 -8957.5
POLA2 -7994.5
GINS4 -7791.5
RFC5 -7715.5
MCM6 -7548.5
PCNA -6647.5
MCM4 -6477.5
PRIM2 -6460.5
MCM8 -6280.5
MCM2 -6252.5
FEN1 -5957.5

Click HERE to show all gene set members

GeneID Gene Rank
POLD2 -10282.5
MCM3 -10019.5
POLA1 -9998.5
LIG1 -9980.5
RPA1 -9890.5
MCM7 -9735.5
RFC3 -9538.5
PRIM1 -9380.5
RFC4 -9363.5
RPA3 -8957.5
POLA2 -7994.5
GINS4 -7791.5
RFC5 -7715.5
MCM6 -7548.5
PCNA -6647.5
MCM4 -6477.5
PRIM2 -6460.5
MCM8 -6280.5
MCM2 -6252.5
FEN1 -5957.5
DNA2 -5899.5
GINS3 -5374.5
POLD1 -4363.5
RPA2 -4279.5
CDC45 -3940.5
RFC1 -3270.5
MCM5 -2276.5
GINS2 -2066.5
GINS1 2963.5
RFC2 6839.5
POLD4 8406.5
POLD3 10715.5


Erythrocytes take up carbon dioxide and release oxygen

343
set Erythrocytes take up carbon dioxide and release oxygen
setSize 12
pANOVA 0.00168
s.dist 0.524
p.adjustANOVA 0.00746



Top enriched genes

GeneID Gene Rank
CYB5R1 10885.5
CA4 10795.5
AQP1 9479.5
CYB5R4 9380.5
CYB5R2 8931.5
RHAG 8052.5
CA1 7975.5
SLC4A1 5560.5
HBB 5190.5
HBA1 4871.5
CA2 449.5
CYB5RL -8263.5

Click HERE to show all gene set members

GeneID Gene Rank
CYB5R1 10885.5
CA4 10795.5
AQP1 9479.5
CYB5R4 9380.5
CYB5R2 8931.5
RHAG 8052.5
CA1 7975.5
SLC4A1 5560.5
HBB 5190.5
HBA1 4871.5
CA2 449.5
CYB5RL -8263.5


O2/CO2 exchange in erythrocytes

763
set O2/CO2 exchange in erythrocytes
setSize 12
pANOVA 0.00168
s.dist 0.524
p.adjustANOVA 0.00746



Top enriched genes

GeneID Gene Rank
CYB5R1 10885.5
CA4 10795.5
AQP1 9479.5
CYB5R4 9380.5
CYB5R2 8931.5
RHAG 8052.5
CA1 7975.5
SLC4A1 5560.5
HBB 5190.5
HBA1 4871.5
CA2 449.5
CYB5RL -8263.5

Click HERE to show all gene set members

GeneID Gene Rank
CYB5R1 10885.5
CA4 10795.5
AQP1 9479.5
CYB5R4 9380.5
CYB5R2 8931.5
RHAG 8052.5
CA1 7975.5
SLC4A1 5560.5
HBB 5190.5
HBA1 4871.5
CA2 449.5
CYB5RL -8263.5


Lagging Strand Synthesis

590
set Lagging Strand Synthesis
setSize 20
pANOVA 5.15e-05
s.dist -0.523
p.adjustANOVA 0.000413



Top enriched genes

GeneID Gene Rank
POLD2 -10282.5
POLA1 -9998.5
LIG1 -9980.5
RPA1 -9890.5
RFC3 -9538.5
PRIM1 -9380.5
RFC4 -9363.5
RPA3 -8957.5
POLA2 -7994.5
RFC5 -7715.5
PCNA -6647.5
PRIM2 -6460.5
FEN1 -5957.5
DNA2 -5899.5
POLD1 -4363.5
RPA2 -4279.5
RFC1 -3270.5
RFC2 6839.5
POLD4 8406.5
POLD3 10715.5

Click HERE to show all gene set members

GeneID Gene Rank
POLD2 -10282.5
POLA1 -9998.5
LIG1 -9980.5
RPA1 -9890.5
RFC3 -9538.5
PRIM1 -9380.5
RFC4 -9363.5
RPA3 -8957.5
POLA2 -7994.5
RFC5 -7715.5
PCNA -6647.5
PRIM2 -6460.5
FEN1 -5957.5
DNA2 -5899.5
POLD1 -4363.5
RPA2 -4279.5
RFC1 -3270.5
RFC2 6839.5
POLD4 8406.5
POLD3 10715.5


RHO GTPases activate CIT

888
set RHO GTPases activate CIT
setSize 18
pANOVA 0.000123
s.dist 0.523
p.adjustANOVA 0.00085



Top enriched genes

GeneID Gene Rank
RAC1 10742.5
MYL6 10203.5
RHOA 9999.5
DLG4 9276.5
MYH9 9127.5
PPP1R12A 8304.5
RHOB 7592.5
PPP1CB 7543.5
MYL12B 6905.5
MYH10 6214.5
RHOC 5884.5
KIF14 5699.5
MYL9 5525.5
PPP1R12B 5168.5
CIT 4241.5
PRC1 3852.5
MYH11 -3227.5
CDKN1B -3321.5

Click HERE to show all gene set members

GeneID Gene Rank
RAC1 10742.5
MYL6 10203.5
RHOA 9999.5
DLG4 9276.5
MYH9 9127.5
PPP1R12A 8304.5
RHOB 7592.5
PPP1CB 7543.5
MYL12B 6905.5
MYH10 6214.5
RHOC 5884.5
KIF14 5699.5
MYL9 5525.5
PPP1R12B 5168.5
CIT 4241.5
PRC1 3852.5
MYH11 -3227.5
CDKN1B -3321.5


Phosphorylation of CD3 and TCR zeta chains

819
set Phosphorylation of CD3 and TCR zeta chains
setSize 27
pANOVA 3.27e-06
s.dist -0.517
p.adjustANOVA 3.74e-05



Top enriched genes

GeneID Gene Rank
TRAV8-4 -10257.5
TRBV12-3 -10110.5
TRAC -9976.5
LCK -9969.5
HLA-DQB2 -9765.5
CD3E -9683.5
TRBC1 -9672.5
TRAV29DV5 -9648.5
HLA-DRA -9153.5
TRAV19 -9034.5
CD3D -8924.5
CD3G -8688.5
CD247 -8683.5
HLA-DPB1 -8545.5
HLA-DPA1 -8407.5
TRBV7-9 -8392.5
HLA-DQA2 -8104.5
HLA-DQA1 -8089.5
CD4 -7093.5
HLA-DQB1 -6039.5

Click HERE to show all gene set members

GeneID Gene Rank
TRAV8-4 -10257.5
TRBV12-3 -10110.5
TRAC -9976.5
LCK -9969.5
HLA-DQB2 -9765.5
CD3E -9683.5
TRBC1 -9672.5
TRAV29DV5 -9648.5
HLA-DRA -9153.5
TRAV19 -9034.5
CD3D -8924.5
CD3G -8688.5
CD247 -8683.5
HLA-DPB1 -8545.5
HLA-DPA1 -8407.5
TRBV7-9 -8392.5
HLA-DQA2 -8104.5
HLA-DQA1 -8089.5
CD4 -7093.5
HLA-DQB1 -6039.5
HLA-DRB1 -1229.5
HLA-DRB5 929.5
PAG1 6472.5
PTPN22 6832.5
PTPRC 7167.5
CSK 8938.5
PTPRJ 10388.5


COPI-independent Golgi-to-ER retrograde traffic

131
set COPI-independent Golgi-to-ER retrograde traffic
setSize 33
pANOVA 3.45e-07
s.dist 0.513
p.adjustANOVA 4.83e-06



Top enriched genes

GeneID Gene Rank
GALNT2 10876.5
DCTN4 10608.5
DCTN2 10587.5
ACTR1A 10120.5
RAB6A 9988.5
PLA2G4A 9955.5
CAPZB 9883.5
CAPZA1 9842.5
BICD2 9626.5
DCTN1 9415.5
CAPZA2 9231.5
DYNC1LI1 8884.5
DYNC1I2 8672.5
PAFAH1B1 8325.5
AGPAT3 8238.5
DCTN6 8147.5
ACTR10 7905.5
GALNT1 7766.5
DCTN3 7462.5
PAFAH1B2 7293.5

Click HERE to show all gene set members

GeneID Gene Rank
GALNT2 10876.5
DCTN4 10608.5
DCTN2 10587.5
ACTR1A 10120.5
RAB6A 9988.5
PLA2G4A 9955.5
CAPZB 9883.5
CAPZA1 9842.5
BICD2 9626.5
DCTN1 9415.5
CAPZA2 9231.5
DYNC1LI1 8884.5
DYNC1I2 8672.5
PAFAH1B1 8325.5
AGPAT3 8238.5
DCTN6 8147.5
ACTR10 7905.5
GALNT1 7766.5
DCTN3 7462.5
PAFAH1B2 7293.5
RAB3GAP2 7229.5
RAB18 7060.5
DYNC1LI2 6706.5
RAB3GAP1 4607.5
DYNLL1 3407.5
DYNC1I1 2705.5
RAB6B 1822.5
DYNC1H1 1223.5
DCTN5 -441.5
PAFAH1B3 -3632.5
BICD1 -3851.5
DYNLL2 -4167.5
PLA2G6 -8041.5


Removal of the Flap Intermediate

993
set Removal of the Flap Intermediate
setSize 14
pANOVA 0.000938
s.dist -0.511
p.adjustANOVA 0.00466



Top enriched genes

GeneID Gene Rank
POLD2 -10282.5
POLA1 -9998.5
RPA1 -9890.5
PRIM1 -9380.5
RPA3 -8957.5
POLA2 -7994.5
PCNA -6647.5
PRIM2 -6460.5
FEN1 -5957.5
DNA2 -5899.5
POLD1 -4363.5
RPA2 -4279.5
POLD4 8406.5
POLD3 10715.5

Click HERE to show all gene set members

GeneID Gene Rank
POLD2 -10282.5
POLA1 -9998.5
RPA1 -9890.5
PRIM1 -9380.5
RPA3 -8957.5
POLA2 -7994.5
PCNA -6647.5
PRIM2 -6460.5
FEN1 -5957.5
DNA2 -5899.5
POLD1 -4363.5
RPA2 -4279.5
POLD4 8406.5
POLD3 10715.5


Prolonged ERK activation events

861
set Prolonged ERK activation events
setSize 13
pANOVA 0.00151
s.dist 0.508
p.adjustANOVA 0.00684



Top enriched genes

GeneID Gene Rank
MAPK1 11021.5
MAP2K1 10453.5
CRK 10400.5
KIDINS220 9186.5
MAPK3 9113.5
RAP1A 8456.5
MAP2K2 7243.5
YWHAB 7135.5
RAPGEF1 4702.5
CRKL 4324.5
BRAF 3033.5
FRS2 -2622.5
NTRK1 -5203.5

Click HERE to show all gene set members

GeneID Gene Rank
MAPK1 11021.5
MAP2K1 10453.5
CRK 10400.5
KIDINS220 9186.5
MAPK3 9113.5
RAP1A 8456.5
MAP2K2 7243.5
YWHAB 7135.5
RAPGEF1 4702.5
CRKL 4324.5
BRAF 3033.5
FRS2 -2622.5
NTRK1 -5203.5


SRP-dependent cotranslational protein targeting to membrane

1038
set SRP-dependent cotranslational protein targeting to membrane
setSize 111
pANOVA 2.12e-20
s.dist -0.508
p.adjustANOVA 9.93e-19



Top enriched genes

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5

Click HERE to show all gene set members

GeneID Gene Rank
RPL23A -10081.5
RPL3 -9996.5
RPL5 -9919.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
SRPRB -7823.5
RPL23 -7793.5
RPL7A -7734.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
SEC11C -6737.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
SEC61A2 -6025.5
RPL8 -5879.5
RPLP1 -5853.5
RPS24 -5521.5
TRAM1 -4313.5
RPL36AL -4244.5
FAU -3126.5
UBA52 -2832.5
RPL28 -2712.5
RPL39L -2073.5
SRP72 -2067.5
RPS26 -1562.5
SSR2 -1517.5
SRP9 -337.5
SEC61G 101.5
SPCS1 216.5
SPCS2 771.5
RPS27L 1022.5
SSR4 1324.5
SRP68 1414.5
SPCS3 2418.5
SRP19 2621.5
SSR1 3318.5
RPS9 3524.5
RPL3L 4102.5
SSR3 4782.5
SEC61B 5455.5
RPL26L1 6687.5
SRP14 6961.5
SEC61A1 7721.5
SRP54 7999.5
SEC11A 8256.5
SRPRA 8334.5
RPN1 8423.5
DDOST 8871.5
RPN2 9244.5
RPS4Y1 10357.5


Golgi Cisternae Pericentriolar Stack Reorganization

466
set Golgi Cisternae Pericentriolar Stack Reorganization
setSize 14
pANOVA 0.00112
s.dist 0.503
p.adjustANOVA 0.00544



Top enriched genes

GeneID Gene Rank
MAPK1 11021.5
RAB2A 10092.5
RAB1A 10071.5
RAB1B 10034.5
GOLGA2 9606.5
MAPK3 9113.5
GORASP1 8269.5
CCNB2 7251.5
BLZF1 4384.5
PLK1 4300.5
USO1 3826.5
CCNB1 1067.5
CDK1 -833.5
GORASP2 -5839.5

Click HERE to show all gene set members

GeneID Gene Rank
MAPK1 11021.5
RAB2A 10092.5
RAB1A 10071.5
RAB1B 10034.5
GOLGA2 9606.5
MAPK3 9113.5
GORASP1 8269.5
CCNB2 7251.5
BLZF1 4384.5
PLK1 4300.5
USO1 3826.5
CCNB1 1067.5
CDK1 -833.5
GORASP2 -5839.5


Neutrophil degranulation

734
set Neutrophil degranulation
setSize 458
pANOVA 2.74e-76
s.dist 0.502
p.adjustANOVA 3.73e-73



Top enriched genes

GeneID Gene Rank
SLC11A1 11255.5
NCSTN 11247.5
IDH1 11234.5
P2RX1 11233.5
LILRB2 11232.5
GNS 11230.5
SIRPA 11219.5
SERPINA1 11216.5
HK3 11211.5
QSOX1 11203.5
DOK3 11202.5
DNASE1L1 11201.5
CD63 11197.5
SIGLEC9 11188.5
HP 11179.5
OSCAR 11178.5
MCEMP1 11171.5
CR1 11155.5
NCKAP1L 11147.5
CTSD 11145.5

Click HERE to show all gene set members

GeneID Gene Rank
SLC11A1 11255.5
NCSTN 11247.5
IDH1 11234.5
P2RX1 11233.5
LILRB2 11232.5
GNS 11230.5
SIRPA 11219.5
SERPINA1 11216.5
HK3 11211.5
QSOX1 11203.5
DOK3 11202.5
DNASE1L1 11201.5
CD63 11197.5
SIGLEC9 11188.5
HP 11179.5
OSCAR 11178.5
MCEMP1 11171.5
CR1 11155.5
NCKAP1L 11147.5
CTSD 11145.5
FGR 11143.5
CTSB 11141.5
C3AR1 11134.5
FCER1G 11091.5
TIMP2 11090.5
IMPDH1 11072.5
SERPINB1 11067.5
PLD1 11063.5
RNASE2 11062.5
S100A12 11059.5
GUSB 11056.5
ITGAM 11047.5
FPR1 11039.5
S100A8 11035.5
MAPK1 11021.5
VNN1 11010.5
PGAM1 11001.5
ATP6V0A1 10998.5
UNC13D 10988.5
ALDH3B1 10980.5
PLAC8 10963.5
AGPAT2 10961.5
VAT1 10955.5
PRKCD 10951.5
LAIR1 10931.5
CD55 10904.5
NEU1 10903.5
RAB10 10894.5
ATP6V0C 10892.5
MAPK14 10886.5
GCA 10883.5
CTSA 10881.5
GM2A 10875.5
TRPM2 10873.5
RETN 10867.5
FPR2 10865.5
ITGB2 10864.5
ALOX5 10861.5
PLEKHO2 10854.5
C5AR1 10843.5
GYG1 10839.5
CD36 10838.5
BRI3 10836.5
ITGAX 10824.5
CD93 10810.5
RAB31 10796.5
ALDOA 10787.5
ADGRG3 10786.5
CD177 10784.5
GRN 10783.5
PYGL 10769.5
ASAH1 10762.5
ANXA2 10761.5
CYB5R3 10758.5
ANPEP 10757.5
NFAM1 10747.5
RAC1 10742.5
S100A11 10740.5
TCIRG1 10730.5
CKAP4 10708.5
MGAM 10704.5
GLA 10699.5
LRG1 10692.5
CRISPLD2 10690.5
CDA 10667.5
ACAA1 10644.5
PKM 10636.5
CYSTM1 10635.5
GPR84 10634.5
TSPAN14 10627.5
TNFAIP6 10622.5
LILRB3 10620.5
TOM1 10619.5
CAPN1 10618.5
RAB3D 10612.5
SLC2A3 10610.5
MMP9 10590.5
GSN 10585.5
BST1 10583.5
CD68 10566.5
MOSPD2 10565.5
MMP25 10543.5
CLEC4D 10534.5
LTA4H 10524.5
COTL1 10516.5
SLC15A4 10511.5
PGM2 10498.5
RHOG 10481.5
QPCT 10474.5
PECAM1 10467.5
S100A9 10452.5
TLR2 10436.5
PSEN1 10429.5
ARPC5 10413.5
ATP11A 10399.5
PTPRJ 10388.5
PYCARD 10380.5
DNAJC5 10373.5
CYFIP1 10366.5
IGF2R 10327.5
GLB1 10317.5
FCGR2A 10308.5
CAT 10280.5
PLAUR 10261.5
CEACAM3 10248.5
FCAR 10246.5
CD53 10241.5
RAB7A 10240.5
ADAM10 10213.5
MGST1 10206.5
PTAFR 10192.5
ACLY 10178.5
ATP6V1D 10161.5
TNFRSF1B 10142.5
FTL 10133.5
CYBA 10117.5
PADI2 10111.5
CTSZ 10107.5
IQGAP1 10093.5
ALAD 10089.5
ARSB 10078.5
TMBIM1 10073.5
DOCK2 10066.5
ARL8A 10056.5
PTPN6 10055.5
NBEAL2 10037.5
AMPD3 10025.5
LAMP1 10022.5
CPPED1 10020.5
RHOA 9999.5
S100P 9992.5
RAB6A 9988.5
SDCBP 9971.5
SELL 9931.5
CAP1 9926.5
DNAJC13 9912.5
VAPA 9887.5
DNAJC3 9884.5
ARG1 9868.5
CD300A 9849.5
RAB5C 9847.5
DERA 9846.5
CTSC 9778.5
CYBB 9756.5
RAB27A 9715.5
LGALS3 9700.5
CMTM6 9686.5
BIN2 9625.5
SNAP29 9604.5
CREG1 9586.5
LAMTOR1 9585.5
AP1M1 9559.5
TOLLIP 9556.5
VPS35L 9553.5
CSTB 9549.5
NAPRT 9547.5
CD44 9541.5
LAMP2 9527.5
CD58 9517.5
ACTR2 9514.5
GMFG 9494.5
DBNL 9488.5
TYROBP 9486.5
CAB39 9453.5
PSAP 9448.5
TRAPPC1 9445.5
AP2A2 9427.5
CFP 9403.5
PRCP 9396.5
IQGAP2 9320.5
CD14 9281.5
MNDA 9271.5
ROCK1 9200.5
APAF1 9038.5
ADGRE5 9036.5
OSTF1 9018.5
HSPA6 8957.5
PSMD1 8916.5
PSMB7 8910.5
PDAP1 8908.5
HSPA1A 8906.5
DYNC1LI1 8884.5
HEXB 8878.5
DDOST 8871.5
PDXK 8865.5
STOM 8841.5
CANT1 8824.5
KCMF1 8816.5
CXCR1 8804.5
SURF4 8738.5
STK10 8728.5
RAB24 8699.5
GALNS 8674.5
SLCO4C1 8663.5
HPSE 8652.5
PSMD2 8639.5
SNAP23 8634.5
GAA 8612.5
MVP 8606.5
LAMTOR2 8601.5
IST1 8597.5
SIGLEC5 8573.5
GPI 8499.5
RAP1B 8483.5
RAP1A 8456.5
OLFM4 8451.5
B4GALT1 8437.5
RAB4B 8380.5
COPB1 8298.5
GGH 8293.5
RNASET2 8282.5
VCP 8258.5
RAB5B 8198.5
FCN1 8151.5
CNN2 8149.5
GDI2 8134.5
COMMD9 8127.5
ATP11B 8119.5
ARHGAP9 8076.5
TMEM30A 8055.5
METTL7A 8044.5
ADAM8 7994.5
MANBA 7955.5
RAP2C 7907.5
ACTR10 7905.5
DIAPH1 7873.5
PSMD11 7867.5
CLEC5A 7840.5
FABP5 7824.5
PSMD12 7823.5
SIRPB1 7773.5
STK11IP 7754.5
TUBB4B 7744.5
CTSS 7571.5
FUCA2 7544.5
ITGAV 7510.5
PNP 7456.5
MMP8 7445.5
SERPINB10 7442.5
FAF2 7419.5
ATP8B4 7378.5
RAB14 7377.5
PGM1 7371.5
ATP6AP2 7363.5
ARSA 7347.5
FOLR3 7340.5
VCL 7317.5
PSMD6 7305.5
PAFAH1B2 7293.5
KCNAB2 7270.5
TARM1 7230.5
PTPRC 7167.5
LPCAT1 7157.5
RAB3A 7108.5
SERPINB6 7094.5
HSPA1B 7070.5
RAB18 7060.5
HEBP2 7047.5
DYNLT1 6997.5
ERP44 6988.5
YPEL5 6975.5
ATG7 6962.5
SRP14 6961.5
STBD1 6950.5
CD33 6903.5
FUCA1 6853.5
FTH1 6682.5
PRDX6 6672.5
LAMTOR3 6564.5
NDUFC2 6359.5
MAN2B1 6341.5
NRAS 6317.5
PGLYRP1 6189.5
MAGT1 6161.5
CXCR2 6132.5
PSMC2 6066.5
CTSH 5915.5
CEACAM1 5825.5
NFASC 5770.5
CSNK2B 5761.5
ANO6 5749.5
PSMD13 5714.5
KPNB1 5712.5
NHLRC3 5646.5
CXCL1 5611.5
APEH 5603.5
NPC2 5580.5
TICAM2 5535.5
C6orf120 5351.5
SLC44A2 5300.5
UBR4 5275.5
CPNE3 5225.5
HBB 5190.5
DEGS1 5180.5
RAP2B 5119.5
PSMD3 5080.5
ARMC8 5016.5
CD59 4916.5
SIGLEC14 4853.5
XRCC5 4710.5
PSMD7 4690.5
GLIPR1 4570.5
RNASE3 4444.5
LRMP 4409.5
ORM1 4193.5
CST3 3917.5
LCN2 3779.5
PLAU 3758.5
FRK 3670.5
PTPRN2 3539.5
DGAT1 3509.5
DYNLL1 3407.5
PTX3 3241.5
PPBP 3183.5
PSMD14 3029.5
CHIT1 2969.5
NFKB1 2947.5
CLEC12A 2926.5
PGRMC1 2920.5
CLEC4C 2228.5
ITGAL 2181.5
PSMC3 2115.5
HLA-C 2089.5
GOLGA7 1857.5
VAMP8 1711.5
FCGR3B 1698.5
GHDC 1597.5
MLEC 1534.5
HGSNAT 1382.5
SLPI 1323.5
CDK13 1283.5
GSTP1 1275.5
CRISP3 1260.5
DYNC1H1 1223.5
AOC1 1222.5
PSMA2 1211.5
TCN1 1178.5
LYZ 1134.5
SYNGR1 965.5
ORM2 587.5
ADGRE3 575.5
PRDX4 551.5
DDX3X 548.5
HLA-B 461.5
NME2 36.5
PYGB -11.5
CCT8 -259.5
BPI -375.5
CEACAM6 -390.5
GSDMD -402.5
ENPP4 -444.5
AGL -454.5
TMEM179B -472.5
CRACR2A -565.5
SVIP -612.5
HVCN1 -631.5
STING1 -690.5
RAB44 -706.5
HUWE1 -800.5
BST2 -829.5
CEACAM8 -830.5
A1BG -1029.5
CFD -1087.5
DEFA1 -1348.5
TUBB -1444.5
LRRC7 -1459.5
PSMB1 -1496.5
LTF -1839.5
HLA-H -1981.5
HSP90AA1 -1986.5
RAB37 -2412.5
DEFA4 -2470.5
FRMPD3 -2576.5
JUP -2601.5
COMMD3 -2615.5
C3 -2655.5
CPNE1 -2687.5
ELANE -2714.5
MPO -2911.5
ABCA13 -3265.5
FGL2 -3318.5
OLR1 -3430.5
SLC2A5 -3474.5
PTPRB -3515.5
PIGR -3597.5
ILF2 -3602.5
PFKL -3784.5
HMGB1 -3833.5
AGA -3962.5
MS4A3 -3995.5
SLC27A2 -4027.5
TXNDC5 -4038.5
PA2G4 -4330.5
CTSG -4395.5
DSN1 -4504.5
SCAMP1 -4522.5
KRT1 -4621.5
AZU1 -4967.5
PRTN3 -5020.5
CHI3L1 -5096.5
PPIA -5176.5
RAB9B -5365.5
EEF2 -5381.5
DSP -5626.5
EPX -5643.5
B2M -5728.5
HRNR -5800.5
XRCC6 -5961.5
HLA-A -5981.5
PSMA5 -5994.5
DPP7 -6032.5
ALDOC -6251.5
MME -6423.5
PTGES2 -6702.5
ORMDL3 -6822.5
ACTR1B -6925.5
MIF -7008.5
APRT -7246.5
CAND1 -7272.5
PPIE -7278.5
CAMP -7327.5
TMC6 -7674.5
CEP290 -7730.5
TBC1D10C -8527.5
RHOF -8771.5
ATAD3B -8832.5
HMOX2 -8861.5
TMEM63A -9199.5
HSPA8 -9227.5
CD47 -9285.5
HSP90AB1 -9287.5
NIT2 -9317.5
EEF1A1 -9507.5
ATP8A1 -9580.5
SPTAN1 -9626.5
DSC1 -9640.5
CCT2 -10188.5
IMPDH2 -10331.5


Generation of second messenger molecules

443
set Generation of second messenger molecules
setSize 38
pANOVA 8.71e-08
s.dist -0.502
p.adjustANOVA 1.46e-06



Top enriched genes

GeneID Gene Rank
TRAV8-4 -10257.5
TRBV12-3 -10110.5
ITK -9983.5
TRAC -9976.5
LCK -9969.5
EVL -9921.5
PLCG1 -9895.5
LAT -9847.5
HLA-DQB2 -9765.5
CD3E -9683.5
TRBC1 -9672.5
TRAV29DV5 -9648.5
ZAP70 -9193.5
HLA-DRA -9153.5
NCK1 -9045.5
TRAV19 -9034.5
CD3D -8924.5
CD3G -8688.5
CD247 -8683.5
HLA-DPB1 -8545.5

Click HERE to show all gene set members

GeneID Gene Rank
TRAV8-4 -10257.5
TRBV12-3 -10110.5
ITK -9983.5
TRAC -9976.5
LCK -9969.5
EVL -9921.5
PLCG1 -9895.5
LAT -9847.5
HLA-DQB2 -9765.5
CD3E -9683.5
TRBC1 -9672.5
TRAV29DV5 -9648.5
ZAP70 -9193.5
HLA-DRA -9153.5
NCK1 -9045.5
TRAV19 -9034.5
CD3D -8924.5
CD3G -8688.5
CD247 -8683.5
HLA-DPB1 -8545.5
HLA-DPA1 -8407.5
TRBV7-9 -8392.5
HLA-DQA2 -8104.5
HLA-DQA1 -8089.5
CD4 -7093.5
HLA-DQB1 -6039.5
PAK3 -5620.5
HLA-DRB1 -1229.5
GRAP2 -719.5
CD101 86.5
HLA-DRB5 929.5
ENAH 1371.5
LCP2 3175.5
PAK2 9322.5
PAK1 9764.5
PLCG2 9819.5
VASP 10058.5
WAS 10446.5


Erythropoietin activates RAS

345
set Erythropoietin activates RAS
setSize 13
pANOVA 0.00177
s.dist 0.501
p.adjustANOVA 0.0078



Top enriched genes

GeneID Gene Rank
LYN 10820.5
GRB2 10779.5
EPOR 10311.5
IRS2 9986.5
VAV1 9732.5
SHC1 9534.5
KRAS 6511.5
NRAS 6317.5
RAPGEF1 4702.5
CRKL 4324.5
JAK2 3436.5
SOS1 -4224.5
HRAS -6026.5

Click HERE to show all gene set members

GeneID Gene Rank
LYN 10820.5
GRB2 10779.5
EPOR 10311.5
IRS2 9986.5
VAV1 9732.5
SHC1 9534.5
KRAS 6511.5
NRAS 6317.5
RAPGEF1 4702.5
CRKL 4324.5
JAK2 3436.5
SOS1 -4224.5
HRAS -6026.5


EPHB-mediated forward signaling

323
set EPHB-mediated forward signaling
setSize 32
pANOVA 9.7e-07
s.dist 0.5
p.adjustANOVA 1.26e-05



Top enriched genes

GeneID Gene Rank
ARPC1A 10888.5
LYN 10820.5
ARPC1B 10781.5
RAC1 10742.5
ITSN1 10738.5
ACTB 10669.5
ARPC5 10413.5
CFL1 10009.5
RHOA 9999.5
ARPC4 9841.5
ACTG1 9779.5
PAK1 9764.5
ACTR2 9514.5
ARPC2 9489.5
ARPC3 9433.5
ACTR3 9282.5
ROCK1 9200.5
CDC42 9089.5
LIMK2 8705.5
LIMK1 8202.5

Click HERE to show all gene set members

GeneID Gene Rank
ARPC1A 10888.5
LYN 10820.5
ARPC1B 10781.5
RAC1 10742.5
ITSN1 10738.5
ACTB 10669.5
ARPC5 10413.5
CFL1 10009.5
RHOA 9999.5
ARPC4 9841.5
ACTG1 9779.5
PAK1 9764.5
ACTR2 9514.5
ARPC2 9489.5
ARPC3 9433.5
ACTR3 9282.5
ROCK1 9200.5
CDC42 9089.5
LIMK2 8705.5
LIMK1 8202.5
ROCK2 7088.5
RASA1 5240.5
SDC2 4154.5
ARHGEF28 2401.5
WASL 1523.5
PTK2 -231.5
YES1 -2789.5
TIAM1 -4176.5
FYN -4514.5
SRC -5586.5
HRAS -6026.5
KALRN -7264.5


Resolution of AP sites via the multiple-nucleotide patch replacement pathway

997
set Resolution of AP sites via the multiple-nucleotide patch replacement pathway
setSize 24
pANOVA 2.43e-05
s.dist -0.498
p.adjustANOVA 0.000219



Top enriched genes

GeneID Gene Rank
APEX1 -10321.5
POLD2 -10282.5
LIG1 -9980.5
RPA1 -9890.5
RFC3 -9538.5
RFC4 -9363.5
POLE3 -9063.5
PARP1 -9015.5
RPA3 -8957.5
RFC5 -7715.5
PARP2 -7470.5
POLB -7381.5
POLE2 -7251.5
PCNA -6647.5
FEN1 -5957.5
POLE -5330.5
POLD1 -4363.5
RPA2 -4279.5
RFC1 -3270.5
POLE4 540.5

Click HERE to show all gene set members

GeneID Gene Rank
APEX1 -10321.5
POLD2 -10282.5
LIG1 -9980.5
RPA1 -9890.5
RFC3 -9538.5
RFC4 -9363.5
POLE3 -9063.5
PARP1 -9015.5
RPA3 -8957.5
RFC5 -7715.5
PARP2 -7470.5
POLB -7381.5
POLE2 -7251.5
PCNA -6647.5
FEN1 -5957.5
POLE -5330.5
POLD1 -4363.5
RPA2 -4279.5
RFC1 -3270.5
POLE4 540.5
PARG 1316.5
RFC2 6839.5
POLD4 8406.5
POLD3 10715.5


RHO GTPases activate PAKs

891
set RHO GTPases activate PAKs
setSize 20
pANOVA 0.000118
s.dist 0.497
p.adjustANOVA 0.00082



Top enriched genes

GeneID Gene Rank
RAC1 10742.5
MYL6 10203.5
PAK1 9764.5
PAK2 9322.5
MYH9 9127.5
CDC42 9089.5
FLNA 8509.5
PPP1R12A 8304.5
LIMK1 8202.5
PPP1CB 7543.5
MYL12B 6905.5
MYH10 6214.5
MYL9 5525.5
PPP1R12B 5168.5
MYLK 4162.5
NF2 4099.5
CTTN 1636.5
CALM1 782.5
MYH11 -3227.5
PAK3 -5620.5

Click HERE to show all gene set members

GeneID Gene Rank
RAC1 10742.5
MYL6 10203.5
PAK1 9764.5
PAK2 9322.5
MYH9 9127.5
CDC42 9089.5
FLNA 8509.5
PPP1R12A 8304.5
LIMK1 8202.5
PPP1CB 7543.5
MYL12B 6905.5
MYH10 6214.5
MYL9 5525.5
PPP1R12B 5168.5
MYLK 4162.5
NF2 4099.5
CTTN 1636.5
CALM1 782.5
MYH11 -3227.5
PAK3 -5620.5


PCNA-Dependent Long Patch Base Excision Repair

775
set PCNA-Dependent Long Patch Base Excision Repair
setSize 21
pANOVA 8.34e-05
s.dist -0.496
p.adjustANOVA 0.000638



Top enriched genes

GeneID Gene Rank
APEX1 -10321.5
POLD2 -10282.5
LIG1 -9980.5
RPA1 -9890.5
RFC3 -9538.5
RFC4 -9363.5
POLE3 -9063.5
RPA3 -8957.5
RFC5 -7715.5
POLB -7381.5
POLE2 -7251.5
PCNA -6647.5
FEN1 -5957.5
POLE -5330.5
POLD1 -4363.5
RPA2 -4279.5
RFC1 -3270.5
POLE4 540.5
RFC2 6839.5
POLD4 8406.5

Click HERE to show all gene set members

GeneID Gene Rank
APEX1 -10321.5
POLD2 -10282.5
LIG1 -9980.5
RPA1 -9890.5
RFC3 -9538.5
RFC4 -9363.5
POLE3 -9063.5
RPA3 -8957.5
RFC5 -7715.5
POLB -7381.5
POLE2 -7251.5
PCNA -6647.5
FEN1 -5957.5
POLE -5330.5
POLD1 -4363.5
RPA2 -4279.5
RFC1 -3270.5
POLE4 540.5
RFC2 6839.5
POLD4 8406.5
POLD3 10715.5


Sema4D in semaphorin signaling

1060
set Sema4D in semaphorin signaling
setSize 22
pANOVA 5.71e-05
s.dist 0.496
p.adjustANOVA 0.000447



Top enriched genes

GeneID Gene Rank
ARHGEF11 11124.5
RAC1 10742.5
RRAS 10668.5
MYL6 10203.5
RHOA 9999.5
ROCK1 9200.5
MYH9 9127.5
LIMK2 8705.5
LIMK1 8202.5
RHOB 7592.5
ROCK2 7088.5
MYL12B 6905.5
MYH10 6214.5
RHOC 5884.5
MYL9 5525.5
RND1 4416.5
ARHGEF12 4291.5
PLXNB1 3994.5
ARHGAP35 -870.5
SEMA4D -2844.5

Click HERE to show all gene set members

GeneID Gene Rank
ARHGEF11 11124.5
RAC1 10742.5
RRAS 10668.5
MYL6 10203.5
RHOA 9999.5
ROCK1 9200.5
MYH9 9127.5
LIMK2 8705.5
LIMK1 8202.5
RHOB 7592.5
ROCK2 7088.5
MYL12B 6905.5
MYH10 6214.5
RHOC 5884.5
MYL9 5525.5
RND1 4416.5
ARHGEF12 4291.5
PLXNB1 3994.5
ARHGAP35 -870.5
SEMA4D -2844.5
MYH11 -3227.5
ERBB2 -5288.5


Detoxification of Reactive Oxygen Species

277
set Detoxification of Reactive Oxygen Species
setSize 32
pANOVA 1.82e-06
s.dist 0.487
p.adjustANOVA 2.27e-05



Top enriched genes

GeneID Gene Rank
GSR 11015.5
NCF2 10695.5
PRDX3 10581.5
NCF4 10309.5
P4HB 10301.5
CAT 10280.5
CYBA 10117.5
TXNRD1 9923.5
ERO1A 9900.5
CYBB 9756.5
GPX3 9474.5
TXN 9458.5
PRDX5 9413.5
GPX1 7667.5
ATOX1 7616.5
NOX5 6830.5
PRDX6 6672.5
TXNRD2 6453.5
SOD2 6367.5
NOX4 5899.5

Click HERE to show all gene set members

GeneID Gene Rank
GSR 11015.5
NCF2 10695.5
PRDX3 10581.5
NCF4 10309.5
P4HB 10301.5
CAT 10280.5
CYBA 10117.5
TXNRD1 9923.5
ERO1A 9900.5
CYBB 9756.5
GPX3 9474.5
TXN 9458.5
PRDX5 9413.5
GPX1 7667.5
ATOX1 7616.5
NOX5 6830.5
PRDX6 6672.5
TXNRD2 6453.5
SOD2 6367.5
NOX4 5899.5
PRDX1 5654.5
NCF1 5367.5
ATP7A 4430.5
TXN2 3908.5
GPX2 3065.5
NUDT2 2240.5
GSTP1 1275.5
CYCS -1916.5
CCS -2672.5
PRDX2 -2820.5
SOD1 -6326.5
GPX7 -8169.5


Trafficking of GluR2-containing AMPA receptors

1246
set Trafficking of GluR2-containing AMPA receptors
setSize 12
pANOVA 0.00362
s.dist 0.485
p.adjustANOVA 0.0136



Top enriched genes

GeneID Gene Rank
AP2A1 11164.5
NSF 10017.5
AP2A2 9427.5
AP2M1 9313.5
PRKCB 9176.5
TSPAN7 8829.5
AP2S1 8776.5
PICK1 7248.5
GRIA4 4383.5
AP2B1 2793.5
PRKCA -3150.5
GRIP1 -9686.5

Click HERE to show all gene set members

GeneID Gene Rank
AP2A1 11164.5
NSF 10017.5
AP2A2 9427.5
AP2M1 9313.5
PRKCB 9176.5
TSPAN7 8829.5
AP2S1 8776.5
PICK1 7248.5
GRIA4 4383.5
AP2B1 2793.5
PRKCA -3150.5
GRIP1 -9686.5


Purine ribonucleoside monophosphate biosynthesis

869
set Purine ribonucleoside monophosphate biosynthesis
setSize 10
pANOVA 0.00797
s.dist -0.485
p.adjustANOVA 0.0256



Top enriched genes

GeneID Gene Rank
IMPDH2 -10331.5
ATIC -10284.5
PPAT -10253.5
PFAS -9873.5
PAICS -9714.5
GMPS -4587.5
ADSL -4376.5
LHPP -3933.5
GART 4386.5
IMPDH1 11072.5

Click HERE to show all gene set members

GeneID Gene Rank
IMPDH2 -10331.5
ATIC -10284.5
PPAT -10253.5
PFAS -9873.5
PAICS -9714.5
GMPS -4587.5
ADSL -4376.5
LHPP -3933.5
GART 4386.5
IMPDH1 11072.5


p130Cas linkage to MAPK signaling for integrins

1340
set p130Cas linkage to MAPK signaling for integrins
setSize 11
pANOVA 0.0054
s.dist 0.484
p.adjustANOVA 0.0187



Top enriched genes

GeneID Gene Rank
APBB1IP 10450.5
CRK 10400.5
TLN1 10359.5
ITGA2B 8575.5
RAP1B 8483.5
RAP1A 8456.5
VWF 5762.5
ITGB3 5547.5
FN1 317.5
PTK2 -231.5
SRC -5586.5

Click HERE to show all gene set members

GeneID Gene Rank
APBB1IP 10450.5
CRK 10400.5
TLN1 10359.5
ITGA2B 8575.5
RAP1B 8483.5
RAP1A 8456.5
VWF 5762.5
ITGB3 5547.5
FN1 317.5
PTK2 -231.5
SRC -5586.5


SLBP independent Processing of Histone Pre-mRNAs

1034
set SLBP independent Processing of Histone Pre-mRNAs
setSize 10
pANOVA 0.008
s.dist -0.484
p.adjustANOVA 0.0257



Top enriched genes

GeneID Gene Rank
ZNF473 -9951.5
NCBP2 -9768.5
LSM11 -9546.5
SNRPE -7343.5
SNRPF -6941.5
SNRPD3 -6090.5
NCBP1 -3005.5
SNRPB -2762.5
SNRPG 1307.5
LSM10 6234.5

Click HERE to show all gene set members

GeneID Gene Rank
ZNF473 -9951.5
NCBP2 -9768.5
LSM11 -9546.5
SNRPE -7343.5
SNRPF -6941.5
SNRPD3 -6090.5
NCBP1 -3005.5
SNRPB -2762.5
SNRPG 1307.5
LSM10 6234.5


Heme degradation

493
set Heme degradation
setSize 10
pANOVA 0.00843
s.dist 0.481
p.adjustANOVA 0.0266



Top enriched genes

GeneID Gene Rank
GUSB 11056.5
HMOX1 10953.5
SLCO2B1 10527.5
BLVRB 9259.5
ALB 8966.5
BLVRA 7415.5
ABCC1 5585.5
ABCG2 3520.5
ABCC2 -1932.5
HMOX2 -8861.5

Click HERE to show all gene set members

GeneID Gene Rank
GUSB 11056.5
HMOX1 10953.5
SLCO2B1 10527.5
BLVRB 9259.5
ALB 8966.5
BLVRA 7415.5
ABCC1 5585.5
ABCG2 3520.5
ABCC2 -1932.5
HMOX2 -8861.5


Hyaluronan metabolism

502
set Hyaluronan metabolism
setSize 15
pANOVA 0.00126
s.dist 0.481
p.adjustANOVA 0.0059



Top enriched genes

GeneID Gene Rank
GUSB 11056.5
SLC9A1 11053.5
HYAL2 11038.5
LYVE1 10594.5
CHP1 10425.5
CD44 9541.5
HEXB 8878.5
HYAL1 8124.5
HMMR 4850.5
STAB2 3610.5
HYAL3 2047.5
HAS3 888.5
ABCC5 -377.5
HEXA -861.5
CEMIP -6156.5

Click HERE to show all gene set members

GeneID Gene Rank
GUSB 11056.5
SLC9A1 11053.5
HYAL2 11038.5
LYVE1 10594.5
CHP1 10425.5
CD44 9541.5
HEXB 8878.5
HYAL1 8124.5
HMMR 4850.5
STAB2 3610.5
HYAL3 2047.5
HAS3 888.5
ABCC5 -377.5
HEXA -861.5
CEMIP -6156.5


Sema4D induced cell migration and growth-cone collapse

1061
set Sema4D induced cell migration and growth-cone collapse
setSize 19
pANOVA 0.00029
s.dist 0.48
p.adjustANOVA 0.00171



Top enriched genes

GeneID Gene Rank
ARHGEF11 11124.5
MYL6 10203.5
RHOA 9999.5
ROCK1 9200.5
MYH9 9127.5
LIMK2 8705.5
LIMK1 8202.5
RHOB 7592.5
ROCK2 7088.5
MYL12B 6905.5
MYH10 6214.5
RHOC 5884.5
MYL9 5525.5
RND1 4416.5
ARHGEF12 4291.5
PLXNB1 3994.5
SEMA4D -2844.5
MYH11 -3227.5
ERBB2 -5288.5

Click HERE to show all gene set members

GeneID Gene Rank
ARHGEF11 11124.5
MYL6 10203.5
RHOA 9999.5
ROCK1 9200.5
MYH9 9127.5
LIMK2 8705.5
LIMK1 8202.5
RHOB 7592.5
ROCK2 7088.5
MYL12B 6905.5
MYH10 6214.5
RHOC 5884.5
MYL9 5525.5
RND1 4416.5
ARHGEF12 4291.5
PLXNB1 3994.5
SEMA4D -2844.5
MYH11 -3227.5
ERBB2 -5288.5


Cargo concentration in the ER

145
set Cargo concentration in the ER
setSize 30
pANOVA 5.4e-06
s.dist 0.48
p.adjustANOVA 5.83e-05



Top enriched genes

GeneID Gene Rank
F5 11235.5
SERPINA1 11216.5
SEC24D 10749.5
TGFA 10604.5
CTSZ 10107.5
CTSC 9778.5
PREB 9561.5
LMAN2 9357.5
SEC24A 9323.5
STX5 8960.5
F8 8744.5
MIA2 8474.5
SAR1B 7611.5
SEC23A 7560.5
TMED2 6875.5
COL7A1 6819.5
SEC24C 6730.5
SEC24B 6356.5
MCFD2 5953.5
AREG 5831.5

Click HERE to show all gene set members

GeneID Gene Rank
F5 11235.5
SERPINA1 11216.5
SEC24D 10749.5
TGFA 10604.5
CTSZ 10107.5
CTSC 9778.5
PREB 9561.5
LMAN2 9357.5
SEC24A 9323.5
STX5 8960.5
F8 8744.5
MIA2 8474.5
SAR1B 7611.5
SEC23A 7560.5
TMED2 6875.5
COL7A1 6819.5
SEC24C 6730.5
SEC24B 6356.5
MCFD2 5953.5
AREG 5831.5
CD59 4916.5
SEC22B 4400.5
LMAN2L 2276.5
GOSR2 2255.5
CNIH2 1622.5
CNIH1 1420.5
TMED10 -2661.5
CNIH3 -3906.5
MIA3 -4383.5
LMAN1 -8899.5


CD22 mediated BCR regulation

121
set CD22 mediated BCR regulation
setSize 59
pANOVA 2.23e-10
s.dist -0.477
p.adjustANOVA 6.06e-09



Top enriched genes

GeneID Gene Rank
IGKV3-11 -9671.5
IGHV4-34 -8850.5
CD79B -8695.5
CD22 -8642.5
IGLV3-21 -8424.5
IGKV1-16 -8400.5
CD79A -7830.5
IGKV1D-39 -7585.5
IGLV3-19 -7563.5
IGKV1-33 -7556.5
IGHV3-33 -7385.5
IGKV3-15 -7363.5
IGLV1-51 -7263.5
IGHV4-59 -7212.5
IGLV2-8 -6935.5
IGHD -6930.5
IGHV4-39 -6787.5
IGHV2-5 -6550.5
IGKV4-1 -6522.5
IGLV3-1 -6475.5

Click HERE to show all gene set members

GeneID Gene Rank
IGKV3-11 -9671.5
IGHV4-34 -8850.5
CD79B -8695.5
CD22 -8642.5
IGLV3-21 -8424.5
IGKV1-16 -8400.5
CD79A -7830.5
IGKV1D-39 -7585.5
IGLV3-19 -7563.5
IGKV1-33 -7556.5
IGHV3-33 -7385.5
IGKV3-15 -7363.5
IGLV1-51 -7263.5
IGHV4-59 -7212.5
IGLV2-8 -6935.5
IGHD -6930.5
IGHV4-39 -6787.5
IGHV2-5 -6550.5
IGKV4-1 -6522.5
IGLV3-1 -6475.5
IGKV2D-28 -6282.5
IGLV2-14 -6281.5
IGKV1-12 -6242.5
IGLV3-25 -6133.5
IGHV3-11 -6127.5
IGLC1 -6045.5
IGHV1-2 -6035.5
IGHV3-48 -5916.5
IGHV3-7 -5788.5
IGKC -5499.5
IGLV6-57 -5414.5
IGLC7 -5361.5
IGLV2-23 -5314.5
IGLC2 -5254.5
IGLV1-40 -5108.5
IGKV1-5 -5035.5
IGKV2-30 -4810.5
IGHV3-23 -4517.5
IGHV3-13 -4257.5
IGLV1-47 -4225.5
IGHM -4127.5
IGHV2-70 -3967.5
IGKV3-20 -3951.5
IGKV3D-20 -3845.5
IGHV3-53 -3569.5
IGLV7-43 -3503.5
IGKV1-17 -3237.5
IGKV2-28 -3097.5
IGHV3-30 -3094.5
IGLV1-44 -2451.5
IGLV3-27 -2116.5
IGHV1-46 -1251.5
IGHV1-69 -1250.5
IGKV5-2 -1181.5
IGLC3 -587.5
IGLV2-11 1116.5
IGKV1-39 4222.5
PTPN6 10055.5
LYN 10820.5


RHO GTPases Activate NADPH Oxidases

885
set RHO GTPases Activate NADPH Oxidases
setSize 21
pANOVA 0.000156
s.dist 0.477
p.adjustANOVA 0.00103



Top enriched genes

GeneID Gene Rank
S100A8 11035.5
MAPK1 11021.5
PRKCD 10951.5
MAPK14 10886.5
RAC1 10742.5
NCF2 10695.5
S100A9 10452.5
NCF4 10309.5
CYBA 10117.5
CYBB 9756.5
PRKCB 9176.5
MAPK3 9113.5
RAC2 7781.5
NCF1 5367.5
PIK3C3 593.5
PIN1 -137.5
MAPK11 -2149.5
PRKCA -3150.5
PIK3R4 -3626.5
NOXA1 -4118.5

Click HERE to show all gene set members

GeneID Gene Rank
S100A8 11035.5
MAPK1 11021.5
PRKCD 10951.5
MAPK14 10886.5
RAC1 10742.5
NCF2 10695.5
S100A9 10452.5
NCF4 10309.5
CYBA 10117.5
CYBB 9756.5
PRKCB 9176.5
MAPK3 9113.5
RAC2 7781.5
NCF1 5367.5
PIK3C3 593.5
PIN1 -137.5
MAPK11 -2149.5
PRKCA -3150.5
PIK3R4 -3626.5
NOXA1 -4118.5
PRKCZ -7254.5


Translation initiation complex formation

1267
set Translation initiation complex formation
setSize 58
pANOVA 3.57e-10
s.dist -0.476
p.adjustANOVA 9.19e-09



Top enriched genes

GeneID Gene Rank
EIF4A2 -9973.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPS27 -9326.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPS2 -9140.5
RPS5 -9136.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPS29 -8844.5
RPS15A -8665.5
RPS7 -8556.5
RPS16 -8540.5
RPS10 -8410.5
RPS18 -8405.5

Click HERE to show all gene set members

GeneID Gene Rank
EIF4A2 -9973.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPS27 -9326.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPS2 -9140.5
RPS5 -9136.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPS29 -8844.5
RPS15A -8665.5
RPS7 -8556.5
RPS16 -8540.5
RPS10 -8410.5
RPS18 -8405.5
RPS13 -8264.5
RPS8 -8088.5
RPS17 -8066.5
RPS28 -8017.5
RPS11 -8011.5
RPS21 -7997.5
EIF3E -7948.5
RPS14 -7901.5
RPS19 -7123.5
EIF4B -6960.5
EIF3L -6949.5
RPSA -6911.5
EIF1AX -6840.5
RPS15 -6115.5
RPS24 -5521.5
EIF3H -4791.5
EIF3F -4537.5
EIF3M -4192.5
EIF3D -4128.5
EIF3J -3884.5
EIF3C -3345.5
FAU -3126.5
EIF3G -2092.5
RPS26 -1562.5
EIF3K -1069.5
EIF3I -600.5
PABPC1 172.5
EIF2S1 226.5
EIF3A 820.5
RPS27L 1022.5
EIF4E 3469.5
RPS9 3524.5
EIF2S2 4457.5
EIF2S3 4893.5
EIF4A1 6944.5
EIF4H 8414.5
RPS4Y1 10357.5
EIF4G1 10367.5


Ribosomal scanning and start codon recognition

1014
set Ribosomal scanning and start codon recognition
setSize 58
pANOVA 5.14e-10
s.dist -0.472
p.adjustANOVA 1.3e-08



Top enriched genes

GeneID Gene Rank
EIF4A2 -9973.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPS27 -9326.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPS2 -9140.5
RPS5 -9136.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPS29 -8844.5
RPS15A -8665.5
RPS7 -8556.5
RPS16 -8540.5
RPS10 -8410.5
RPS18 -8405.5

Click HERE to show all gene set members

GeneID Gene Rank
EIF4A2 -9973.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPS27 -9326.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPS2 -9140.5
RPS5 -9136.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPS29 -8844.5
RPS15A -8665.5
RPS7 -8556.5
RPS16 -8540.5
RPS10 -8410.5
RPS18 -8405.5
RPS13 -8264.5
RPS8 -8088.5
RPS17 -8066.5
RPS28 -8017.5
RPS11 -8011.5
RPS21 -7997.5
EIF3E -7948.5
RPS14 -7901.5
RPS19 -7123.5
EIF4B -6960.5
EIF3L -6949.5
RPSA -6911.5
EIF1AX -6840.5
RPS15 -6115.5
RPS24 -5521.5
EIF3H -4791.5
EIF3F -4537.5
EIF3M -4192.5
EIF3D -4128.5
EIF3J -3884.5
EIF3C -3345.5
FAU -3126.5
EIF3G -2092.5
RPS26 -1562.5
EIF3K -1069.5
EIF3I -600.5
EIF2S1 226.5
EIF3A 820.5
RPS27L 1022.5
EIF5 2874.5
EIF4E 3469.5
RPS9 3524.5
EIF2S2 4457.5
EIF2S3 4893.5
EIF4A1 6944.5
EIF4H 8414.5
RPS4Y1 10357.5
EIF4G1 10367.5


Telomere C-strand (Lagging Strand) Synthesis

1217
set Telomere C-strand (Lagging Strand) Synthesis
setSize 34
pANOVA 2.26e-06
s.dist -0.468
p.adjustANOVA 2.75e-05



Top enriched genes

GeneID Gene Rank
POLD2 -10282.5
STN1 -10155.5
POLA1 -9998.5
LIG1 -9980.5
CHTF18 -9937.5
RPA1 -9890.5
WRN -9878.5
RFC3 -9538.5
CTC1 -9504.5
PRIM1 -9380.5
RFC4 -9363.5
RPA3 -8957.5
POLA2 -7994.5
RFC5 -7715.5
ACD -6668.5
PCNA -6647.5
PRIM2 -6460.5
FEN1 -5957.5
DNA2 -5899.5
DSCC1 -5102.5

Click HERE to show all gene set members

GeneID Gene Rank
POLD2 -10282.5
STN1 -10155.5
POLA1 -9998.5
LIG1 -9980.5
CHTF18 -9937.5
RPA1 -9890.5
WRN -9878.5
RFC3 -9538.5
CTC1 -9504.5
PRIM1 -9380.5
RFC4 -9363.5
RPA3 -8957.5
POLA2 -7994.5
RFC5 -7715.5
ACD -6668.5
PCNA -6647.5
PRIM2 -6460.5
FEN1 -5957.5
DNA2 -5899.5
DSCC1 -5102.5
POLD1 -4363.5
BLM -4297.5
RPA2 -4279.5
POT1 -4037.5
TERF2 -3896.5
RFC1 -3270.5
CHTF8 -1706.5
TERF1 -336.5
TEN1 290.5
TERF2IP 4777.5
RFC2 6839.5
TINF2 7725.5
POLD4 8406.5
POLD3 10715.5


Activation of ATR in response to replication stress

33
set Activation of ATR in response to replication stress
setSize 37
pANOVA 8.78e-07
s.dist -0.467
p.adjustANOVA 1.15e-05



Top enriched genes

GeneID Gene Rank
RAD1 -10149.5
MCM3 -10019.5
RPA1 -9890.5
MCM7 -9735.5
RFC3 -9538.5
RFC4 -9363.5
RAD17 -9036.5
RPA3 -8957.5
ORC5 -8775.5
ORC2 -8711.5
DBF4 -8549.5
ORC3 -8240.5
RFC5 -7715.5
RAD9A -7664.5
MCM6 -7548.5
MCM4 -6477.5
MCM8 -6280.5
ATR -6278.5
MCM2 -6252.5
ORC4 -5885.5

Click HERE to show all gene set members

GeneID Gene Rank
RAD1 -10149.5
MCM3 -10019.5
RPA1 -9890.5
MCM7 -9735.5
RFC3 -9538.5
RFC4 -9363.5
RAD17 -9036.5
RPA3 -8957.5
ORC5 -8775.5
ORC2 -8711.5
DBF4 -8549.5
ORC3 -8240.5
RFC5 -7715.5
RAD9A -7664.5
MCM6 -7548.5
MCM4 -6477.5
MCM8 -6280.5
ATR -6278.5
MCM2 -6252.5
ORC4 -5885.5
ATRIP -5820.5
CDC7 -4953.5
CHEK1 -4655.5
RPA2 -4279.5
CDK2 -4114.5
CDC45 -3940.5
MCM10 -3818.5
MCM5 -2276.5
ORC1 -633.5
CDC6 -226.5
CDC25A 238.5
HUS1 912.5
CLSPN 4483.5
CDC25C 4518.5
RAD9B 5371.5
RFC2 6839.5
ORC6 7450.5


GPVI-mediated activation cascade

429
set GPVI-mediated activation cascade
setSize 31
pANOVA 6.96e-06
s.dist 0.466
p.adjustANOVA 7.35e-05



Top enriched genes

GeneID Gene Rank
FCER1G 11091.5
LYN 10820.5
RAC1 10742.5
RHOG 10481.5
SYK 10443.5
PTPN6 10055.5
RHOA 9999.5
PLCG2 9819.5
VAV1 9732.5
PIK3CB 9508.5
PIK3R6 9497.5
CLEC1B 9381.5
PIK3CG 9315.5
CDC42 9089.5
VAV3 8706.5
PDPK1 8648.5
RAC2 7781.5
RHOB 7592.5
GP6 7112.5
PTPN11 7102.5

Click HERE to show all gene set members

GeneID Gene Rank
FCER1G 11091.5
LYN 10820.5
RAC1 10742.5
RHOG 10481.5
SYK 10443.5
PTPN6 10055.5
RHOA 9999.5
PLCG2 9819.5
VAV1 9732.5
PIK3CB 9508.5
PIK3R6 9497.5
CLEC1B 9381.5
PIK3CG 9315.5
CDC42 9089.5
VAV3 8706.5
PDPK1 8648.5
RAC2 7781.5
RHOB 7592.5
GP6 7112.5
PTPN11 7102.5
PIK3R2 5882.5
PIK3R5 5691.5
LCP2 3175.5
PIK3R3 2936.5
PIK3CA 2781.5
VAV2 2301.5
FYN -4514.5
PRKCZ -7254.5
PIK3R1 -8072.5
LAT -9847.5
LCK -9969.5


Recycling pathway of L1

942
set Recycling pathway of L1
setSize 26
pANOVA 3.94e-05
s.dist 0.466
p.adjustANOVA 0.000335



Top enriched genes

GeneID Gene Rank
AP2A1 11164.5
NUMB 11161.5
MAPK1 11021.5
RPS6KA1 10908.5
CLTC 10405.5
DPYSL2 10214.5
MSN 9917.5
DNM2 9784.5
AP2A2 9427.5
AP2M1 9313.5
AP2S1 8776.5
RDX 8529.5
SHTN1 8458.5
CLTA 8425.5
DNM1 7143.5
DNM3 6241.5
KIF4A 5768.5
RPS6KA2 4387.5
AP2B1 2793.5
RPS6KA4 1299.5

Click HERE to show all gene set members

GeneID Gene Rank
AP2A1 11164.5
NUMB 11161.5
MAPK1 11021.5
RPS6KA1 10908.5
CLTC 10405.5
DPYSL2 10214.5
MSN 9917.5
DNM2 9784.5
AP2A2 9427.5
AP2M1 9313.5
AP2S1 8776.5
RDX 8529.5
SHTN1 8458.5
CLTA 8425.5
DNM1 7143.5
DNM3 6241.5
KIF4A 5768.5
RPS6KA2 4387.5
AP2B1 2793.5
RPS6KA4 1299.5
RPS6KA3 917.5
EZR -440.5
RPS6KA6 -3823.5
L1CAM -4098.5
SRC -5586.5
RPS6KA5 -9661.5


Pre-NOTCH Processing in Golgi

845
set Pre-NOTCH Processing in Golgi
setSize 18
pANOVA 0.000677
s.dist 0.463
p.adjustANOVA 0.00354



Top enriched genes

GeneID Gene Rank
NOTCH3 11222.5
FURIN 10794.5
RAB6A 9988.5
ST3GAL4 9906.5
ATP2A2 9866.5
NOTCH4 9620.5
B4GALT1 8437.5
SEL1L 8197.5
NOTCH1 8062.5
NOTCH2 7798.5
TMED2 6875.5
ST3GAL6 3765.5
RFNG 3237.5
ATP2A3 1656.5
LFNG 454.5
ATP2A1 -296.5
ST3GAL3 -3811.5
MFNG -7707.5

Click HERE to show all gene set members

GeneID Gene Rank
NOTCH3 11222.5
FURIN 10794.5
RAB6A 9988.5
ST3GAL4 9906.5
ATP2A2 9866.5
NOTCH4 9620.5
B4GALT1 8437.5
SEL1L 8197.5
NOTCH1 8062.5
NOTCH2 7798.5
TMED2 6875.5
ST3GAL6 3765.5
RFNG 3237.5
ATP2A3 1656.5
LFNG 454.5
ATP2A1 -296.5
ST3GAL3 -3811.5
MFNG -7707.5


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

49
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 59
pANOVA 8.66e-10
s.dist -0.461
p.adjustANOVA 2.1e-08



Top enriched genes

GeneID Gene Rank
EIF4A2 -9973.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPS27 -9326.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPS2 -9140.5
RPS5 -9136.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPS29 -8844.5
RPS15A -8665.5
RPS7 -8556.5
RPS16 -8540.5
RPS10 -8410.5
RPS18 -8405.5

Click HERE to show all gene set members

GeneID Gene Rank
EIF4A2 -9973.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPS27 -9326.5
RPS20 -9206.5
EIF3B -9188.5
RPS3 -9175.5
RPS2 -9140.5
RPS5 -9136.5
RPS23 -9089.5
RPS12 -9042.5
RPS4X -8943.5
RPS29 -8844.5
RPS15A -8665.5
RPS7 -8556.5
RPS16 -8540.5
RPS10 -8410.5
RPS18 -8405.5
RPS13 -8264.5
RPS8 -8088.5
RPS17 -8066.5
RPS28 -8017.5
RPS11 -8011.5
RPS21 -7997.5
EIF3E -7948.5
RPS14 -7901.5
RPS19 -7123.5
EIF4B -6960.5
EIF3L -6949.5
RPSA -6911.5
EIF1AX -6840.5
RPS15 -6115.5
RPS24 -5521.5
EIF3H -4791.5
EIF3F -4537.5
EIF3M -4192.5
EIF3D -4128.5
EIF3J -3884.5
EIF3C -3345.5
FAU -3126.5
EIF3G -2092.5
RPS26 -1562.5
EIF3K -1069.5
EIF3I -600.5
PABPC1 172.5
EIF2S1 226.5
EIF3A 820.5
RPS27L 1022.5
EIF4E 3469.5
RPS9 3524.5
EIF2S2 4457.5
EIF4EBP1 4569.5
EIF2S3 4893.5
EIF4A1 6944.5
EIF4H 8414.5
RPS4Y1 10357.5
EIF4G1 10367.5


Mucopolysaccharidoses

681
set Mucopolysaccharidoses
setSize 11
pANOVA 0.00826
s.dist 0.46
p.adjustANOVA 0.0261



Top enriched genes

GeneID Gene Rank
GNS 11230.5
GUSB 11056.5
GLB1 10317.5
ARSB 10078.5
GALNS 8674.5
HYAL1 8124.5
IDS 1989.5
NAGLU 1769.5
SGSH 1404.5
HGSNAT 1382.5
IDUA -6407.5

Click HERE to show all gene set members

GeneID Gene Rank
GNS 11230.5
GUSB 11056.5
GLB1 10317.5
ARSB 10078.5
GALNS 8674.5
HYAL1 8124.5
IDS 1989.5
NAGLU 1769.5
SGSH 1404.5
HGSNAT 1382.5
IDUA -6407.5


Insulin receptor recycling

538
set Insulin receptor recycling
setSize 21
pANOVA 0.000265
s.dist 0.46
p.adjustANOVA 0.0016



Top enriched genes

GeneID Gene Rank
ATP6AP1 11165.5
ATP6V0A1 10998.5
ATP6V0D1 10898.5
ATP6V0C 10892.5
TCIRG1 10730.5
ATP6V1D 10161.5
ATP6V1A 9987.5
INSR 9833.5
ATP6V1B2 9801.5
ATP6V1C1 9787.5
ATP6V0B 9596.5
ATP6V0E1 9090.5
ATP6V1H 8786.5
ATP6V1E1 8774.5
ATP6V1F 4565.5
ATP6V1E2 -661.5
ATP6V1G1 -1582.5
ATP6V1C2 -3202.5
ATP6V0A2 -6690.5
ATP6V1G2 -9516.5

Click HERE to show all gene set members

GeneID Gene Rank
ATP6AP1 11165.5
ATP6V0A1 10998.5
ATP6V0D1 10898.5
ATP6V0C 10892.5
TCIRG1 10730.5
ATP6V1D 10161.5
ATP6V1A 9987.5
INSR 9833.5
ATP6V1B2 9801.5
ATP6V1C1 9787.5
ATP6V0B 9596.5
ATP6V0E1 9090.5
ATP6V1H 8786.5
ATP6V1E1 8774.5
ATP6V1F 4565.5
ATP6V1E2 -661.5
ATP6V1G1 -1582.5
ATP6V1C2 -3202.5
ATP6V0A2 -6690.5
ATP6V1G2 -9516.5
ATP6V0E2 -9692.5


RHO GTPases activate PKNs

892
set RHO GTPases activate PKNs
setSize 48
pANOVA 3.6e-08
s.dist 0.459
p.adjustANOVA 6.72e-07



Top enriched genes

GeneID Gene Rank
H2AJ 11245.5
RAC1 10742.5
YWHAH 10517.5
YWHAG 10431.5
MYL6 10203.5
RHOA 9999.5
PAK1 9764.5
YWHAE 9729.5
H3-3A 9447.5
H2BC21 9334.5
MYH9 9127.5
H2BC12 9121.5
H2BC4 9026.5
PDPK1 8648.5
PPP1R12A 8304.5
H2AC20 8020.5
RHOB 7592.5
PPP1CB 7543.5
PKN1 7526.5
H2BC5 7381.5

Click HERE to show all gene set members

GeneID Gene Rank
H2AJ 11245.5
RAC1 10742.5
YWHAH 10517.5
YWHAG 10431.5
MYL6 10203.5
RHOA 9999.5
PAK1 9764.5
YWHAE 9729.5
H3-3A 9447.5
H2BC21 9334.5
MYH9 9127.5
H2BC12 9121.5
H2BC4 9026.5
PDPK1 8648.5
PPP1R12A 8304.5
H2AC20 8020.5
RHOB 7592.5
PPP1CB 7543.5
PKN1 7526.5
H2BC5 7381.5
YWHAB 7135.5
H2BC11 7099.5
MYL12B 6905.5
H3C15 6893.0
H2BC17 6809.5
YWHAZ 6774.5
H2AC6 6663.5
NCOA2 6464.5
AR 6352.5
MYH10 6214.5
RHOC 5884.5
MYL9 5525.5
KLK2 5415.5
H2BC15 5304.5
H2AZ1 5209.5
PPP1R12B 5168.5
CDC25C 4518.5
SFN 804.5
PPP1R14A 299.5
PKN3 188.5
PKN2 -1606.5
H2BU1 -1758.5
MYH11 -3227.5
YWHAQ -3229.5
H2BC9 -3296.5
H2AZ2 -3759.5
KDM4C -5430.5
KDM1A -7497.5


BBSome-mediated cargo-targeting to cilium

98
set BBSome-mediated cargo-targeting to cilium
setSize 22
pANOVA 0.000216
s.dist -0.456
p.adjustANOVA 0.00136



Top enriched genes

GeneID Gene Rank
CCT2 -10188.5
BBS9 -8658.5
BBS1 -8572.5
BBS2 -8445.5
LZTFL1 -8348.5
ARL6 -8241.5
BBS5 -8168.5
SSTR3 -7052.5
CCT3 -5881.5
CCT4 -5711.5
BBIP1 -5635.5
MKKS -5479.5
BBS10 -5301.5
BBS4 -4551.5
TCP1 -2756.5
MCHR1 -1970.5
BBS7 -1757.5
BBS12 -262.5
CCT8 -259.5
RAB3IP 85.5

Click HERE to show all gene set members

GeneID Gene Rank
CCT2 -10188.5
BBS9 -8658.5
BBS1 -8572.5
BBS2 -8445.5
LZTFL1 -8348.5
ARL6 -8241.5
BBS5 -8168.5
SSTR3 -7052.5
CCT3 -5881.5
CCT4 -5711.5
BBIP1 -5635.5
MKKS -5479.5
BBS10 -5301.5
BBS4 -4551.5
TCP1 -2756.5
MCHR1 -1970.5
BBS7 -1757.5
BBS12 -262.5
CCT8 -259.5
RAB3IP 85.5
TTC8 3334.5
CCT5 5410.5


Influenza Infection

525
set Influenza Infection
setSize 154
pANOVA 1.8e-22
s.dist -0.455
p.adjustANOVA 9.06e-21



Top enriched genes

GeneID Gene Rank
IPO5 -10318.5
NDC1 -10267.5
RPL23A -10081.5
NUP35 -10072.5
NUP88 -10035.5
RPL3 -9996.5
RPL5 -9919.5
SEH1L -9831.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
KPNA5 -9324.5
RPL34 -9307.5

Click HERE to show all gene set members

GeneID Gene Rank
IPO5 -10318.5
NDC1 -10267.5
RPL23A -10081.5
NUP35 -10072.5
NUP88 -10035.5
RPL3 -9996.5
RPL5 -9919.5
SEH1L -9831.5
RPL14 -9806.5
RPS27A -9724.5
RPS25 -9690.5
RPS3A -9656.5
RPS6 -9628.5
RPL22 -9409.5
RPL13A -9379.5
RPL32 -9372.5
RPL7 -9343.5
RPS27 -9326.5
KPNA5 -9324.5
RPL34 -9307.5
RPLP2 -9270.5
RPS20 -9206.5
RPS3 -9175.5
RPL4 -9156.5
RPS2 -9140.5
RPS5 -9136.5
RPL21 -9102.5
RPS23 -9089.5
NUP160 -9065.5
RPS12 -9042.5
PARP1 -9015.5
RPS4X -8943.5
RPL12 -8913.5
RPS29 -8844.5
RPL35A -8833.5
RPL30 -8765.5
RPL10A -8721.5
RPL11 -8705.5
RPL18A -8694.5
RPS15A -8665.5
NUP188 -8637.5
RPL6 -8602.5
RPL18 -8582.5
RPL10 -8562.5
RPS7 -8556.5
NUP43 -8552.5
RPL31 -8551.5
RPS16 -8540.5
RPL27A -8509.5
RPLP0 -8498.5
RPL17 -8493.5
RPL36A -8469.5
RPS10 -8410.5
RPS18 -8405.5
RPL29 -8292.5
NUP205 -8276.5
RPS13 -8264.5
RPL39 -8261.5
RPL26 -8249.5
NUP107 -8214.5
RPS8 -8088.5
RPS17 -8066.5
RPL19 -8038.5
RPS28 -8017.5
RPS11 -8011.5
RPL24 -8010.5
RPS21 -7997.5
RPS14 -7901.5
RPL23 -7793.5
RAN -7744.5
RPL7A -7734.5
NUP54 -7606.5
NUP155 -7509.5
RPL37 -7436.5
RPL9 -7396.5
RPL15 -7319.5
RPL41 -7257.5
RPL38 -7234.5
RPL27 -7182.5
RPS19 -7123.5
RPL36 -6990.5
POLR2H -6977.5
RPL13 -6954.5
RPSA -6911.5
RPL35 -6772.5
RPL22L1 -6495.5
RPL37A -6190.5
RPS15 -6115.5
RPL8 -5879.5
RPLP1 -5853.5
POLR2D -5810.5
NUP133 -5672.5
RPS24 -5521.5
ISG15 -5321.5
NUP93 -5318.5
NUP210 -5216.5
AAAS -4800.5
TPR -4491.5
RPL36AL -4244.5
CPSF4 -4111.5
POLR2I -3650.5
POLR2K -3481.5
NUP42 -3330.5
SLC25A6 -3278.5
NUP85 -3271.5
FAU -3126.5
NUP62 -3092.5
POM121 -2842.5
UBA52 -2832.5
RPL28 -2712.5
XPO1 -2543.5
POLR2B -2474.5
RPL39L -2073.5
RANBP2 -2053.5
HSP90AA1 -1986.5
NUP153 -1942.5
POM121C -1794.5
RPS26 -1562.5
POLR2C -1418.5
KPNA1 -1235.5
PABPN1 -1137.5
KPNA3 -40.5
GRSF1 109.5
KPNA2 217.5
NUP37 369.5
RPS27L 1022.5
POLR2L 2259.5
RPS9 3524.5
RAE1 3714.5
NUP50 4037.5
NUP98 4046.5
RPL3L 4102.5
POLR2F 4110.5
EIF2AK2 4364.5
POLR2G 4797.5
POLR2J 5259.5
CANX 5534.5
KPNB1 5712.5
POLR2E 6145.5
KPNA4 6298.5
SEC13 6386.5
TGFB1 6499.5
RPL26L1 6687.5
POLR2A 6928.5
GTF2F1 7017.5
GTF2F2 7096.5
CALR 7491.5
CLTA 8425.5
HSPA1A 8906.5
NUP214 9446.5
NUP58 9569.5
DNAJC3 9884.5
RPS4Y1 10357.5
CLTC 10405.5


RNA Polymerase I Promoter Opening

900
set RNA Polymerase I Promoter Opening
setSize 19
pANOVA 0.000601
s.dist 0.455
p.adjustANOVA 0.00323



Top enriched genes

GeneID Gene Rank
H2AJ 11245.5
H3-3A 9447.5
H2BC21 9334.5
H2BC12 9121.5
MAPK3 9113.5
MBD2 9044.5
H2BC4 9026.5
H2AC20 8020.5
H2BC5 7381.5
H2BC11 7099.5
H3C15 6893.0
H2BC17 6809.5
H2AC6 6663.5
H2BC15 5304.5
H2AZ1 5209.5
H2BU1 -1758.5
H2BC9 -3296.5
H2AZ2 -3759.5
UBTF -9030.5

Click HERE to show all gene set members

GeneID Gene Rank
H2AJ 11245.5
H3-3A 9447.5
H2BC21 9334.5
H2BC12 9121.5
MAPK3 9113.5
MBD2 9044.5
H2BC4 9026.5
H2AC20 8020.5
H2BC5 7381.5
H2BC11 7099.5
H3C15 6893.0
H2BC17 6809.5
H2AC6 6663.5
H2BC15 5304.5
H2AZ1 5209.5
H2BU1 -1758.5
H2BC9 -3296.5
H2AZ2 -3759.5
UBTF -9030.5


Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

981
set Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
setSize 11
pANOVA 0.00915
s.dist 0.454
p.adjustANOVA 0.0284



Top enriched genes

GeneID Gene Rank
PRKACA 11194.5
PFKFB4 11185.5
PFKFB3 10837.5
PFKFB2 9845.5
PPP2CB 8306.5
PPP2CA 7872.5
PPP2R5D 6173.5
PPP2R1A 5497.5
PPP2R1B -79.5
PFKFB1 -1813.5
PRKACB -10125.5

Click HERE to show all gene set members

GeneID Gene Rank
PRKACA 11194.5
PFKFB4 11185.5
PFKFB3 10837.5
PFKFB2 9845.5
PPP2CB 8306.5
PPP2CA 7872.5
PPP2R5D 6173.5
PPP2R1A 5497.5
PPP2R1B -79.5
PFKFB1 -1813.5
PRKACB -10125.5


Synthesis of Leukotrienes (LT) and Eoxins (EX)

1164
set Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize 15
pANOVA 0.00235
s.dist 0.454
p.adjustANOVA 0.00963



Top enriched genes

GeneID Gene Rank
GGT1 11252.5
ALOX5 10861.5
PTGR1 10850.5
LTA4H 10524.5
ALOX5AP 9631.5
CYP4F8 9265.5
MAPKAPK2 9191.5
CYP4F3 6332.5
ABCC1 5585.5
CYP4F22 4577.5
GGT5 2358.5
DPEP2 1199.5
DPEP3 661.5
LTC4S -2107.5
ALOX15 -9916.5

Click HERE to show all gene set members

GeneID Gene Rank
GGT1 11252.5
ALOX5 10861.5
PTGR1 10850.5
LTA4H 10524.5
ALOX5AP 9631.5
CYP4F8 9265.5
MAPKAPK2 9191.5
CYP4F3 6332.5
ABCC1 5585.5
CYP4F22 4577.5
GGT5 2358.5
DPEP2 1199.5
DPEP3 661.5
LTC4S -2107.5
ALOX15 -9916.5


Signaling by Erythropoietin

1083
set Signaling by Erythropoietin
setSize 24
pANOVA 0.000144
s.dist 0.448
p.adjustANOVA 0.000958



Top enriched genes

GeneID Gene Rank
LYN 10820.5
GRB2 10779.5
EPOR 10311.5
IRS2 9986.5
PLCG2 9819.5
VAV1 9732.5
SHC1 9534.5
PIK3CB 9508.5
PIK3CG 9315.5
GAB1 8186.5
STAT5A 8089.5
STAT5B 7820.5
PIK3CD 7499.5
KRAS 6511.5
NRAS 6317.5
PIK3R5 5691.5
RAPGEF1 4702.5
CRKL 4324.5
JAK2 3436.5
PIK3CA 2781.5

Click HERE to show all gene set members

GeneID Gene Rank
LYN 10820.5
GRB2 10779.5
EPOR 10311.5
IRS2 9986.5
PLCG2 9819.5
VAV1 9732.5
SHC1 9534.5
PIK3CB 9508.5
PIK3CG 9315.5
GAB1 8186.5
STAT5A 8089.5
STAT5B 7820.5
PIK3CD 7499.5
KRAS 6511.5
NRAS 6317.5
PIK3R5 5691.5
RAPGEF1 4702.5
CRKL 4324.5
JAK2 3436.5
PIK3CA 2781.5
SOS1 -4224.5
HRAS -6026.5
PIK3R1 -8072.5
PLCG1 -9895.5


Dissolution of Fibrin Clot

299
set Dissolution of Fibrin Clot
setSize 12
pANOVA 0.00726
s.dist 0.448
p.adjustANOVA 0.0236



Top enriched genes

GeneID Gene Rank
ANXA2 10761.5
SERPINB2 10455.5
PLAUR 10261.5
SERPINB8 9668.5
S100A10 7329.5
SERPINB6 7094.5
SERPINE2 6532.5
SERPINE1 6449.5
PLAU 3758.5
PLG -654.5
SERPINF2 -2387.5
PLAT -5829.5

Click HERE to show all gene set members

GeneID Gene Rank
ANXA2 10761.5
SERPINB2 10455.5
PLAUR 10261.5
SERPINB8 9668.5
S100A10 7329.5
SERPINB6 7094.5
SERPINE2 6532.5
SERPINE1 6449.5
PLAU 3758.5
PLG -654.5
SERPINF2 -2387.5
PLAT -5829.5


MAP2K and MAPK activation

609
set MAP2K and MAPK activation
setSize 34
pANOVA 6.35e-06
s.dist 0.447
p.adjustANOVA 6.75e-05



Top enriched genes

GeneID Gene Rank
MAPK1 11021.5
MAP2K1 10453.5
APBB1IP 10450.5
ARRB2 10447.5
TLN1 10359.5
MARK3 10350.5
IQGAP1 10093.5
KSR1 9844.5
MAPK3 9113.5
CSK 8938.5
RAF1 8661.5
LAMTOR2 8601.5
ITGA2B 8575.5
RAP1B 8483.5
RAP1A 8456.5
VCL 7317.5
MAP2K2 7243.5
YWHAB 7135.5
LAMTOR3 6564.5
KRAS 6511.5

Click HERE to show all gene set members

GeneID Gene Rank
MAPK1 11021.5
MAP2K1 10453.5
APBB1IP 10450.5
ARRB2 10447.5
TLN1 10359.5
MARK3 10350.5
IQGAP1 10093.5
KSR1 9844.5
MAPK3 9113.5
CSK 8938.5
RAF1 8661.5
LAMTOR2 8601.5
ITGA2B 8575.5
RAP1B 8483.5
RAP1A 8456.5
VCL 7317.5
MAP2K2 7243.5
YWHAB 7135.5
LAMTOR3 6564.5
KRAS 6511.5
NRAS 6317.5
WDR83 6204.5
VWF 5762.5
ITGB3 5547.5
ARRB1 5509.5
ARAF 5317.5
BRAF 3033.5
FN1 317.5
KSR2 -620.5
SRC -5586.5
HRAS -6026.5
CNKSR2 -6210.5
CNKSR1 -8756.5
PEBP1 -9972.5


Diseases associated with the TLR signaling cascade

287
set Diseases associated with the TLR signaling cascade
setSize 23
pANOVA 0.000219
s.dist 0.445
p.adjustANOVA 0.00136



Top enriched genes

GeneID Gene Rank
MYD88 11089.5
TLR5 10914.5
CD36 10838.5
BTK 10811.5
TLR2 10436.5
UNC93B1 10322.5
TLR4 9795.5
TLR1 9684.5
LY96 9679.5
CD14 9281.5
IKBKG 9033.5
CHUK 8909.5
TIRAP 8635.5
TLR6 8611.5
TICAM1 7759.5
NFKBIA 4541.5
NFKB1 2947.5
RELA -973.5
IKBKB -1399.5
NFKB2 -5887.5

Click HERE to show all gene set members

GeneID Gene Rank
MYD88 11089.5
TLR5 10914.5
CD36 10838.5
BTK 10811.5
TLR2 10436.5
UNC93B1 10322.5
TLR4 9795.5
TLR1 9684.5
LY96 9679.5
CD14 9281.5
IKBKG 9033.5
CHUK 8909.5
TIRAP 8635.5
TLR6 8611.5
TICAM1 7759.5
NFKBIA 4541.5
NFKB1 2947.5
RELA -973.5
IKBKB -1399.5
NFKB2 -5887.5
TLR3 -7704.5
TLR10 -8148.5
TRAF3 -8255.5


Diseases of Immune System

289
set Diseases of Immune System
setSize 23
pANOVA 0.000219
s.dist 0.445
p.adjustANOVA 0.00136



Top enriched genes

GeneID Gene Rank
MYD88 11089.5
TLR5 10914.5
CD36 10838.5
BTK 10811.5
TLR2 10436.5
UNC93B1 10322.5
TLR4 9795.5
TLR1 9684.5
LY96 9679.5
CD14 9281.5
IKBKG 9033.5
CHUK 8909.5
TIRAP 8635.5
TLR6 8611.5
TICAM1 7759.5
NFKBIA 4541.5
NFKB1 2947.5
RELA -973.5
IKBKB -1399.5
NFKB2 -5887.5

Click HERE to show all gene set members

GeneID Gene Rank
MYD88 11089.5
TLR5 10914.5
CD36 10838.5
BTK 10811.5
TLR2 10436.5
UNC93B1 10322.5
TLR4 9795.5
TLR1 9684.5
LY96 9679.5
CD14 9281.5
IKBKG 9033.5
CHUK 8909.5
TIRAP 8635.5
TLR6 8611.5
TICAM1 7759.5
NFKBIA 4541.5
NFKB1 2947.5
RELA -973.5
IKBKB -1399.5
NFKB2 -5887.5
TLR3 -7704.5
TLR10 -8148.5
TRAF3 -8255.5


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.4                
##  [7] MASS_7.3-51.6               fgsea_1.14.0               
##  [9] gplots_3.0.3                DESeq2_1.28.1              
## [11] SummarizedExperiment_1.18.1 DelayedArray_0.14.0        
## [13] matrixStats_0.56.0          Biobase_2.48.0             
## [15] GenomicRanges_1.40.0        GenomeInfoDb_1.24.2        
## [17] IRanges_2.22.2              S4Vectors_0.26.1           
## [19] BiocGenerics_0.34.0         reshape2_1.4.4             
## [21] forcats_0.5.0               stringr_1.4.0              
## [23] dplyr_1.0.0                 purrr_0.3.4                
## [25] readr_1.3.1                 tidyr_1.1.0                
## [27] tibble_3.0.1                ggplot2_3.3.2              
## [29] tidyverse_1.3.0            
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.1               rstudioapi_0.11       
##  [7] farver_2.0.3           bit64_0.9-7            AnnotationDbi_1.50.0  
## [10] fansi_0.4.1            lubridate_1.7.9        xml2_1.3.2            
## [13] splines_4.0.2          geneplotter_1.66.0     knitr_1.28            
## [16] jsonlite_1.6.1         broom_0.5.6            annotate_1.66.0       
## [19] dbplyr_1.4.4           shiny_1.4.0.2          compiler_4.0.2        
## [22] httr_1.4.1             backports_1.1.8        fastmap_1.0.1         
## [25] assertthat_0.2.1       Matrix_1.2-18          cli_2.0.2             
## [28] later_1.1.0.1          htmltools_0.5.0        tools_4.0.2           
## [31] gtable_0.3.0           glue_1.4.1             GenomeInfoDbData_1.2.3
## [34] fastmatch_1.1-0        Rcpp_1.0.4.6           cellranger_1.1.0      
## [37] vctrs_0.3.1            gdata_2.18.0           nlme_3.1-148          
## [40] xfun_0.15              testthat_2.3.2         rvest_0.3.5           
## [43] mime_0.9               lifecycle_0.2.0        XML_3.99-0.3          
## [46] zlibbioc_1.34.0        scales_1.1.1           promises_1.1.1        
## [49] hms_0.5.3              RColorBrewer_1.1-2     yaml_2.2.1            
## [52] memoise_1.1.0          gridExtra_2.3          reshape_0.8.8         
## [55] stringi_1.4.6          RSQLite_2.2.0          highr_0.8             
## [58] genefilter_1.70.0      desc_1.2.0             caTools_1.18.0        
## [61] BiocParallel_1.22.0    rlang_0.4.6            pkgconfig_2.0.3       
## [64] bitops_1.0-6           evaluate_0.14          lattice_0.20-41       
## [67] labeling_0.3           htmlwidgets_1.5.1      bit_1.1-15.2          
## [70] tidyselect_1.1.0       plyr_1.8.6             magrittr_1.5          
## [73] R6_2.4.1               generics_0.0.2         DBI_1.1.0             
## [76] pillar_1.4.4           haven_2.3.1            withr_2.2.0           
## [79] survival_3.2-3         RCurl_1.98-1.2         modelr_0.1.8          
## [82] crayon_1.3.4           KernSmooth_2.23-17     rmarkdown_2.3         
## [85] locfit_1.5-9.4         grid_4.0.2             readxl_1.3.1          
## [88] data.table_1.12.8      blob_1.2.1             reprex_0.3.0          
## [91] digest_0.6.25          pbmcapply_1.5.0        xtable_1.8-4          
## [94] httpuv_1.5.4           munsell_0.5.0

END of report