Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2020-07-02
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## x
## A1BG -3.3590111
## A1BG-AS1 -0.7824907
## A1CF 0.1338318
## A2M 1.2404397
## A2M-AS1 0.6133565
## A2ML1 2.2932412Here are some metrics about the input data profile:
| Profile metrics | |
|---|---|
| num_genesets | 2400 |
| num_genes_in_profile | 22124 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 8472 |
| num_profile_genes_not_in_sets | 13652 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes.
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
| Gene sets metrics | |
|---|---|
| num_genesets | 2400 |
| num_genesets_excluded | 1035 |
| num_genesets_included | 1365 |
Differential pathway expression
Interactive enrichment scatterplot
Significance is calculated by -log10(p-value). All points shown are FDR<0.05.
Results table
Top N= 100 gene sets
| set | setSize | pANOVA | s.dist | p.adjustANOVA |
|---|---|---|---|---|
| Peptide chain elongation | 88 | 1.04e-44 | -0.863 | 5.85e-42 |
| Eukaryotic Translation Elongation | 93 | 1.22e-46 | -0.858 | 1.66e-43 |
| Viral mRNA Translation | 88 | 6.81e-42 | -0.835 | 1.86e-39 |
| Eukaryotic Translation Termination | 92 | 1.49e-42 | -0.823 | 5.09e-40 |
| Formation of a pool of free 40S subunits | 100 | 1.29e-44 | -0.809 | 5.85e-42 |
| Selenocysteine synthesis | 92 | 5.23e-41 | -0.807 | 1.19e-38 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 94 | 1.13e-38 | -0.775 | 1.44e-36 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 110 | 7.75e-41 | -0.737 | 1.51e-38 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 111 | 1.28e-39 | -0.722 | 2.19e-37 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 100 | 1.34e-34 | -0.709 | 1.52e-32 |
| Cap-dependent Translation Initiation | 118 | 1.16e-38 | -0.692 | 1.44e-36 |
| Eukaryotic Translation Initiation | 118 | 1.16e-38 | -0.692 | 1.44e-36 |
| SRP-dependent cotranslational protein targeting to membrane | 111 | 1.07e-33 | -0.664 | 9.13e-32 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 114 | 1.00e-33 | -0.655 | 9.12e-32 |
| Nonsense-Mediated Decay (NMD) | 114 | 1.00e-33 | -0.655 | 9.12e-32 |
| Formation of the ternary complex, and subsequently, the 43S complex | 51 | 1.28e-15 | -0.647 | 5.00e-14 |
| Selenoamino acid metabolism | 114 | 1.59e-30 | -0.622 | 1.14e-28 |
| Influenza Viral RNA Transcription and Replication | 135 | 3.52e-33 | -0.597 | 2.82e-31 |
| Translation initiation complex formation | 58 | 4.37e-15 | -0.595 | 1.61e-13 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 59 | 2.91e-15 | -0.594 | 1.10e-13 |
| Ribosomal scanning and start codon recognition | 58 | 5.56e-15 | -0.593 | 2.00e-13 |
| VLDLR internalisation and degradation | 11 | 1.21e-03 | -0.563 | 1.21e-02 |
| Formation of ATP by chemiosmotic coupling | 18 | 3.70e-05 | -0.562 | 5.81e-04 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 11 | 2.25e-03 | -0.532 | 2.00e-02 |
| Pausing and recovery of Tat-mediated HIV elongation | 30 | 9.60e-07 | -0.517 | 2.15e-05 |
| Tat-mediated HIV elongation arrest and recovery | 30 | 9.60e-07 | -0.517 | 2.15e-05 |
| Regulation of expression of SLITs and ROBOs | 162 | 8.66e-30 | -0.515 | 5.91e-28 |
| Influenza Infection | 154 | 1.01e-27 | -0.509 | 6.28e-26 |
| Josephin domain DUBs | 10 | 6.16e-03 | -0.500 | 4.10e-02 |
| RNA Polymerase I Promoter Opening | 19 | 2.84e-04 | -0.481 | 3.52e-03 |
| WNT5A-dependent internalization of FZD4 | 13 | 2.68e-03 | -0.481 | 2.20e-02 |
| Olfactory Signaling Pathway | 61 | 1.27e-10 | 0.476 | 3.95e-09 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 16 | 1.03e-03 | -0.474 | 1.06e-02 |
| rRNA processing in the nucleus and cytosol | 190 | 1.93e-29 | -0.473 | 1.26e-27 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 180 | 1.07e-27 | -0.471 | 6.37e-26 |
| DNA methylation | 20 | 2.70e-04 | -0.470 | 3.39e-03 |
| rRNA processing | 219 | 8.95e-32 | -0.459 | 6.79e-30 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | 21 | 3.34e-04 | -0.452 | 4.06e-03 |
| Pexophagy | 11 | 9.66e-03 | -0.451 | 5.51e-02 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 32 | 1.04e-05 | -0.450 | 1.89e-04 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | 23 | 1.93e-04 | -0.449 | 2.52e-03 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | 11 | 1.09e-02 | 0.443 | 6.05e-02 |
| Cristae formation | 31 | 2.16e-05 | -0.441 | 3.60e-04 |
| HIV elongation arrest and recovery | 32 | 1.86e-05 | -0.437 | 3.14e-04 |
| Pausing and recovery of HIV elongation | 32 | 1.86e-05 | -0.437 | 3.14e-04 |
| NF-kB is activated and signals survival | 12 | 9.28e-03 | -0.434 | 5.39e-02 |
| Inhibition of DNA recombination at telomere | 35 | 9.61e-06 | -0.432 | 1.80e-04 |
| Signaling by ROBO receptors | 202 | 1.44e-25 | -0.426 | 7.54e-24 |
| Assembly Of The HIV Virion | 15 | 4.54e-03 | -0.423 | 3.29e-02 |
| Cytosolic iron-sulfur cluster assembly | 13 | 8.28e-03 | -0.423 | 5.03e-02 |
| RMTs methylate histone arginines | 37 | 9.21e-06 | -0.421 | 1.75e-04 |
| Synthesis of PIPs at the late endosome membrane | 11 | 1.56e-02 | 0.421 | 7.77e-02 |
| Packaging Of Telomere Ends | 20 | 1.16e-03 | -0.420 | 1.18e-02 |
| Complex I biogenesis | 55 | 7.67e-08 | -0.419 | 1.94e-06 |
| HSF1-dependent transactivation | 29 | 1.08e-04 | -0.415 | 1.50e-03 |
| Glycogen storage diseases | 13 | 9.80e-03 | -0.414 | 5.55e-02 |
| Cleavage of the damaged purine | 24 | 4.57e-04 | -0.413 | 5.29e-03 |
| Depurination | 24 | 4.57e-04 | -0.413 | 5.29e-03 |
| Recognition and association of DNA glycosylase with site containing an affected purine | 24 | 4.57e-04 | -0.413 | 5.29e-03 |
| Translation | 295 | 2.65e-34 | -0.413 | 2.78e-32 |
| Mitochondrial translation elongation | 91 | 1.60e-11 | -0.409 | 5.32e-10 |
| Glycogen synthesis | 13 | 1.09e-02 | -0.408 | 6.05e-02 |
| AKT phosphorylates targets in the nucleus | 10 | 2.59e-02 | -0.407 | 1.07e-01 |
| Interleukin-2 signaling | 11 | 1.96e-02 | -0.406 | 9.04e-02 |
| Regulation of TP53 Activity through Acetylation | 29 | 1.53e-04 | -0.406 | 2.07e-03 |
| tRNA processing in the mitochondrion | 32 | 7.31e-05 | -0.405 | 1.07e-03 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 124 | 2.05e-14 | -0.397 | 7.18e-13 |
| Trafficking of GluR2-containing AMPA receptors | 12 | 1.99e-02 | -0.388 | 9.13e-02 |
| Base-Excision Repair, AP Site Formation | 31 | 1.94e-04 | -0.387 | 2.52e-03 |
| Respiratory electron transport | 101 | 1.86e-11 | -0.387 | 6.06e-10 |
| SUMOylation of immune response proteins | 11 | 2.67e-02 | -0.386 | 1.09e-01 |
| Repression of WNT target genes | 14 | 1.25e-02 | -0.386 | 6.61e-02 |
| Pentose phosphate pathway | 13 | 1.66e-02 | -0.384 | 8.16e-02 |
| Downregulation of ERBB2:ERBB3 signaling | 12 | 2.18e-02 | -0.382 | 9.60e-02 |
| FOXO-mediated transcription of cell death genes | 16 | 8.40e-03 | -0.381 | 5.03e-02 |
| mRNA Splicing - Minor Pathway | 52 | 2.22e-06 | -0.379 | 4.45e-05 |
| Condensation of Prometaphase Chromosomes | 11 | 3.03e-02 | 0.377 | 1.19e-01 |
| Mitochondrial translation initiation | 91 | 6.78e-10 | -0.374 | 2.06e-08 |
| Regulation of localization of FOXO transcription factors | 12 | 2.52e-02 | -0.373 | 1.05e-01 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | 22 | 2.65e-03 | -0.370 | 2.20e-02 |
| Mitochondrial translation termination | 91 | 1.26e-09 | -0.368 | 3.75e-08 |
| HSF1 activation | 26 | 1.20e-03 | -0.367 | 1.21e-02 |
| Folding of actin by CCT/TriC | 10 | 4.50e-02 | -0.366 | 1.54e-01 |
| Regulation of TP53 Activity through Association with Co-factors | 12 | 2.84e-02 | -0.365 | 1.13e-01 |
| SLBP independent Processing of Histone Pre-mRNAs | 10 | 4.59e-02 | -0.365 | 1.57e-01 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 26 | 1.35e-03 | 0.363 | 1.32e-02 |
| Attenuation phase | 23 | 2.58e-03 | -0.363 | 2.17e-02 |
| Cleavage of the damaged pyrimidine | 29 | 7.17e-04 | -0.363 | 7.77e-03 |
| Depyrimidination | 29 | 7.17e-04 | -0.363 | 7.77e-03 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | 29 | 7.17e-04 | -0.363 | 7.77e-03 |
| The role of Nef in HIV-1 replication and disease pathogenesis | 28 | 9.08e-04 | -0.362 | 9.39e-03 |
| SUMOylation of DNA methylation proteins | 16 | 1.21e-02 | -0.362 | 6.55e-02 |
| rRNA processing in the mitochondrion | 29 | 7.90e-04 | -0.360 | 8.28e-03 |
| Acetylcholine Neurotransmitter Release Cycle | 11 | 4.37e-02 | -0.351 | 1.52e-01 |
| Spry regulation of FGF signaling | 16 | 1.52e-02 | -0.350 | 7.62e-02 |
| Mitochondrial translation | 97 | 2.56e-09 | -0.350 | 7.43e-08 |
| Mitochondrial protein import | 64 | 1.52e-06 | -0.347 | 3.29e-05 |
| Membrane binding and targetting of GAG proteins | 13 | 3.07e-02 | -0.346 | 1.20e-01 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | 13 | 3.07e-02 | -0.346 | 1.20e-01 |
| CDC6 association with the ORC:origin complex | 11 | 4.78e-02 | 0.345 | 1.62e-01 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pANOVA | s.dist | p.adjustANOVA |
|---|---|---|---|---|
| Peptide chain elongation | 88 | 1.04e-44 | -0.863000 | 5.85e-42 |
| Eukaryotic Translation Elongation | 93 | 1.22e-46 | -0.858000 | 1.66e-43 |
| Viral mRNA Translation | 88 | 6.81e-42 | -0.835000 | 1.86e-39 |
| Eukaryotic Translation Termination | 92 | 1.49e-42 | -0.823000 | 5.09e-40 |
| Formation of a pool of free 40S subunits | 100 | 1.29e-44 | -0.809000 | 5.85e-42 |
| Selenocysteine synthesis | 92 | 5.23e-41 | -0.807000 | 1.19e-38 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 94 | 1.13e-38 | -0.775000 | 1.44e-36 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 110 | 7.75e-41 | -0.737000 | 1.51e-38 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 111 | 1.28e-39 | -0.722000 | 2.19e-37 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 100 | 1.34e-34 | -0.709000 | 1.52e-32 |
| Cap-dependent Translation Initiation | 118 | 1.16e-38 | -0.692000 | 1.44e-36 |
| Eukaryotic Translation Initiation | 118 | 1.16e-38 | -0.692000 | 1.44e-36 |
| SRP-dependent cotranslational protein targeting to membrane | 111 | 1.07e-33 | -0.664000 | 9.13e-32 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 114 | 1.00e-33 | -0.655000 | 9.12e-32 |
| Nonsense-Mediated Decay (NMD) | 114 | 1.00e-33 | -0.655000 | 9.12e-32 |
| Formation of the ternary complex, and subsequently, the 43S complex | 51 | 1.28e-15 | -0.647000 | 5.00e-14 |
| Selenoamino acid metabolism | 114 | 1.59e-30 | -0.622000 | 1.14e-28 |
| Influenza Viral RNA Transcription and Replication | 135 | 3.52e-33 | -0.597000 | 2.82e-31 |
| Translation initiation complex formation | 58 | 4.37e-15 | -0.595000 | 1.61e-13 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 59 | 2.91e-15 | -0.594000 | 1.10e-13 |
| Ribosomal scanning and start codon recognition | 58 | 5.56e-15 | -0.593000 | 2.00e-13 |
| VLDLR internalisation and degradation | 11 | 1.21e-03 | -0.563000 | 1.21e-02 |
| Formation of ATP by chemiosmotic coupling | 18 | 3.70e-05 | -0.562000 | 5.81e-04 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 11 | 2.25e-03 | -0.532000 | 2.00e-02 |
| Pausing and recovery of Tat-mediated HIV elongation | 30 | 9.60e-07 | -0.517000 | 2.15e-05 |
| Tat-mediated HIV elongation arrest and recovery | 30 | 9.60e-07 | -0.517000 | 2.15e-05 |
| Regulation of expression of SLITs and ROBOs | 162 | 8.66e-30 | -0.515000 | 5.91e-28 |
| Influenza Infection | 154 | 1.01e-27 | -0.509000 | 6.28e-26 |
| Josephin domain DUBs | 10 | 6.16e-03 | -0.500000 | 4.10e-02 |
| RNA Polymerase I Promoter Opening | 19 | 2.84e-04 | -0.481000 | 3.52e-03 |
| WNT5A-dependent internalization of FZD4 | 13 | 2.68e-03 | -0.481000 | 2.20e-02 |
| Olfactory Signaling Pathway | 61 | 1.27e-10 | 0.476000 | 3.95e-09 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 16 | 1.03e-03 | -0.474000 | 1.06e-02 |
| rRNA processing in the nucleus and cytosol | 190 | 1.93e-29 | -0.473000 | 1.26e-27 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 180 | 1.07e-27 | -0.471000 | 6.37e-26 |
| DNA methylation | 20 | 2.70e-04 | -0.470000 | 3.39e-03 |
| rRNA processing | 219 | 8.95e-32 | -0.459000 | 6.79e-30 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | 21 | 3.34e-04 | -0.452000 | 4.06e-03 |
| Pexophagy | 11 | 9.66e-03 | -0.451000 | 5.51e-02 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 32 | 1.04e-05 | -0.450000 | 1.89e-04 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | 23 | 1.93e-04 | -0.449000 | 2.52e-03 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | 11 | 1.09e-02 | 0.443000 | 6.05e-02 |
| Cristae formation | 31 | 2.16e-05 | -0.441000 | 3.60e-04 |
| HIV elongation arrest and recovery | 32 | 1.86e-05 | -0.437000 | 3.14e-04 |
| Pausing and recovery of HIV elongation | 32 | 1.86e-05 | -0.437000 | 3.14e-04 |
| NF-kB is activated and signals survival | 12 | 9.28e-03 | -0.434000 | 5.39e-02 |
| Inhibition of DNA recombination at telomere | 35 | 9.61e-06 | -0.432000 | 1.80e-04 |
| Signaling by ROBO receptors | 202 | 1.44e-25 | -0.426000 | 7.54e-24 |
| Assembly Of The HIV Virion | 15 | 4.54e-03 | -0.423000 | 3.29e-02 |
| Cytosolic iron-sulfur cluster assembly | 13 | 8.28e-03 | -0.423000 | 5.03e-02 |
| RMTs methylate histone arginines | 37 | 9.21e-06 | -0.421000 | 1.75e-04 |
| Synthesis of PIPs at the late endosome membrane | 11 | 1.56e-02 | 0.421000 | 7.77e-02 |
| Packaging Of Telomere Ends | 20 | 1.16e-03 | -0.420000 | 1.18e-02 |
| Complex I biogenesis | 55 | 7.67e-08 | -0.419000 | 1.94e-06 |
| HSF1-dependent transactivation | 29 | 1.08e-04 | -0.415000 | 1.50e-03 |
| Glycogen storage diseases | 13 | 9.80e-03 | -0.414000 | 5.55e-02 |
| Cleavage of the damaged purine | 24 | 4.57e-04 | -0.413000 | 5.29e-03 |
| Depurination | 24 | 4.57e-04 | -0.413000 | 5.29e-03 |
| Recognition and association of DNA glycosylase with site containing an affected purine | 24 | 4.57e-04 | -0.413000 | 5.29e-03 |
| Translation | 295 | 2.65e-34 | -0.413000 | 2.78e-32 |
| Mitochondrial translation elongation | 91 | 1.60e-11 | -0.409000 | 5.32e-10 |
| Glycogen synthesis | 13 | 1.09e-02 | -0.408000 | 6.05e-02 |
| AKT phosphorylates targets in the nucleus | 10 | 2.59e-02 | -0.407000 | 1.07e-01 |
| Interleukin-2 signaling | 11 | 1.96e-02 | -0.406000 | 9.04e-02 |
| Regulation of TP53 Activity through Acetylation | 29 | 1.53e-04 | -0.406000 | 2.07e-03 |
| tRNA processing in the mitochondrion | 32 | 7.31e-05 | -0.405000 | 1.07e-03 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 124 | 2.05e-14 | -0.397000 | 7.18e-13 |
| Trafficking of GluR2-containing AMPA receptors | 12 | 1.99e-02 | -0.388000 | 9.13e-02 |
| Base-Excision Repair, AP Site Formation | 31 | 1.94e-04 | -0.387000 | 2.52e-03 |
| Respiratory electron transport | 101 | 1.86e-11 | -0.387000 | 6.06e-10 |
| SUMOylation of immune response proteins | 11 | 2.67e-02 | -0.386000 | 1.09e-01 |
| Repression of WNT target genes | 14 | 1.25e-02 | -0.386000 | 6.61e-02 |
| Pentose phosphate pathway | 13 | 1.66e-02 | -0.384000 | 8.16e-02 |
| Downregulation of ERBB2:ERBB3 signaling | 12 | 2.18e-02 | -0.382000 | 9.60e-02 |
| FOXO-mediated transcription of cell death genes | 16 | 8.40e-03 | -0.381000 | 5.03e-02 |
| mRNA Splicing - Minor Pathway | 52 | 2.22e-06 | -0.379000 | 4.45e-05 |
| Condensation of Prometaphase Chromosomes | 11 | 3.03e-02 | 0.377000 | 1.19e-01 |
| Mitochondrial translation initiation | 91 | 6.78e-10 | -0.374000 | 2.06e-08 |
| Regulation of localization of FOXO transcription factors | 12 | 2.52e-02 | -0.373000 | 1.05e-01 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | 22 | 2.65e-03 | -0.370000 | 2.20e-02 |
| Mitochondrial translation termination | 91 | 1.26e-09 | -0.368000 | 3.75e-08 |
| HSF1 activation | 26 | 1.20e-03 | -0.367000 | 1.21e-02 |
| Folding of actin by CCT/TriC | 10 | 4.50e-02 | -0.366000 | 1.54e-01 |
| Regulation of TP53 Activity through Association with Co-factors | 12 | 2.84e-02 | -0.365000 | 1.13e-01 |
| SLBP independent Processing of Histone Pre-mRNAs | 10 | 4.59e-02 | -0.365000 | 1.57e-01 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 26 | 1.35e-03 | 0.363000 | 1.32e-02 |
| Attenuation phase | 23 | 2.58e-03 | -0.363000 | 2.17e-02 |
| Cleavage of the damaged pyrimidine | 29 | 7.17e-04 | -0.363000 | 7.77e-03 |
| Depyrimidination | 29 | 7.17e-04 | -0.363000 | 7.77e-03 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | 29 | 7.17e-04 | -0.363000 | 7.77e-03 |
| The role of Nef in HIV-1 replication and disease pathogenesis | 28 | 9.08e-04 | -0.362000 | 9.39e-03 |
| SUMOylation of DNA methylation proteins | 16 | 1.21e-02 | -0.362000 | 6.55e-02 |
| rRNA processing in the mitochondrion | 29 | 7.90e-04 | -0.360000 | 8.28e-03 |
| Acetylcholine Neurotransmitter Release Cycle | 11 | 4.37e-02 | -0.351000 | 1.52e-01 |
| Spry regulation of FGF signaling | 16 | 1.52e-02 | -0.350000 | 7.62e-02 |
| Mitochondrial translation | 97 | 2.56e-09 | -0.350000 | 7.43e-08 |
| Mitochondrial protein import | 64 | 1.52e-06 | -0.347000 | 3.29e-05 |
| Membrane binding and targetting of GAG proteins | 13 | 3.07e-02 | -0.346000 | 1.20e-01 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | 13 | 3.07e-02 | -0.346000 | 1.20e-01 |
| CDC6 association with the ORC:origin complex | 11 | 4.78e-02 | 0.345000 | 1.62e-01 |
| N-Glycan antennae elongation | 13 | 3.18e-02 | -0.344000 | 1.22e-01 |
| Disorders of developmental biology | 12 | 4.04e-02 | -0.342000 | 1.44e-01 |
| Loss of function of MECP2 in Rett syndrome | 12 | 4.04e-02 | -0.342000 | 1.44e-01 |
| Pervasive developmental disorders | 12 | 4.04e-02 | -0.342000 | 1.44e-01 |
| Incretin synthesis, secretion, and inactivation | 10 | 6.24e-02 | 0.340000 | 1.90e-01 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 10 | 6.24e-02 | 0.340000 | 1.90e-01 |
| EGFR downregulation | 27 | 2.29e-03 | -0.339000 | 2.00e-02 |
| Collagen chain trimerization | 27 | 2.43e-03 | -0.337000 | 2.08e-02 |
| MicroRNA (miRNA) biogenesis | 24 | 4.32e-03 | -0.337000 | 3.22e-02 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 11 | 5.37e-02 | -0.336000 | 1.74e-01 |
| Regulation of FZD by ubiquitination | 16 | 2.01e-02 | -0.336000 | 9.17e-02 |
| RNA Polymerase III Chain Elongation | 18 | 1.45e-02 | -0.333000 | 7.38e-02 |
| Regulation of PTEN gene transcription | 59 | 1.00e-05 | -0.332000 | 1.85e-04 |
| Base Excision Repair | 58 | 1.28e-05 | -0.331000 | 2.26e-04 |
| PIWI-interacting RNA (piRNA) biogenesis | 24 | 5.08e-03 | -0.330000 | 3.54e-02 |
| N-glycan antennae elongation in the medial/trans-Golgi | 21 | 8.83e-03 | -0.330000 | 5.22e-02 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 22 | 7.43e-03 | -0.330000 | 4.67e-02 |
| Nucleobase biosynthesis | 13 | 3.98e-02 | -0.329000 | 1.43e-01 |
| Senescence-Associated Secretory Phenotype (SASP) | 66 | 4.06e-06 | -0.328000 | 7.92e-05 |
| HDACs deacetylate histones | 47 | 1.10e-04 | -0.326000 | 1.51e-03 |
| PINK1-PRKN Mediated Mitophagy | 21 | 9.80e-03 | -0.326000 | 5.55e-02 |
| Interferon alpha/beta signaling | 57 | 2.20e-05 | 0.325000 | 3.62e-04 |
| Late endosomal microautophagy | 30 | 2.10e-03 | -0.324000 | 1.92e-02 |
| Retrograde neurotrophin signalling | 12 | 5.50e-02 | -0.320000 | 1.74e-01 |
| Telomere Maintenance | 80 | 1.13e-06 | -0.315000 | 2.48e-05 |
| Tryptophan catabolism | 12 | 6.02e-02 | 0.313000 | 1.86e-01 |
| Downregulation of ERBB2 signaling | 24 | 8.38e-03 | -0.311000 | 5.03e-02 |
| PRC2 methylates histones and DNA | 29 | 3.96e-03 | -0.309000 | 3.00e-02 |
| MET activates RAP1 and RAC1 | 10 | 9.11e-02 | 0.309000 | 2.43e-01 |
| CD28 dependent PI3K/Akt signaling | 22 | 1.24e-02 | -0.308000 | 6.60e-02 |
| Nef mediated downregulation of MHC class I complex cell surface expression | 10 | 9.30e-02 | -0.307000 | 2.48e-01 |
| Gluconeogenesis | 28 | 5.01e-03 | -0.306000 | 3.52e-02 |
| Diseases of carbohydrate metabolism | 29 | 4.30e-03 | -0.306000 | 3.22e-02 |
| Purine catabolism | 16 | 3.44e-02 | -0.306000 | 1.28e-01 |
| Constitutive Signaling by AKT1 E17K in Cancer | 26 | 7.23e-03 | -0.304000 | 4.58e-02 |
| Uptake and function of anthrax toxins | 10 | 9.58e-02 | -0.304000 | 2.52e-01 |
| Formation of the beta-catenin:TCF transactivating complex | 46 | 3.58e-04 | -0.304000 | 4.32e-03 |
| Chaperone Mediated Autophagy | 20 | 1.86e-02 | -0.304000 | 8.75e-02 |
| Norepinephrine Neurotransmitter Release Cycle | 13 | 5.88e-02 | -0.303000 | 1.83e-01 |
| Collagen biosynthesis and modifying enzymes | 46 | 3.82e-04 | -0.303000 | 4.57e-03 |
| Advanced glycosylation endproduct receptor signaling | 12 | 7.02e-02 | -0.302000 | 2.06e-01 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | 29 | 4.92e-03 | -0.302000 | 3.49e-02 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | 42 | 7.41e-04 | -0.301000 | 7.84e-03 |
| HIV Transcription Elongation | 42 | 7.41e-04 | -0.301000 | 7.84e-03 |
| Tat-mediated elongation of the HIV-1 transcript | 42 | 7.41e-04 | -0.301000 | 7.84e-03 |
| TBC/RABGAPs | 45 | 4.89e-04 | -0.300000 | 5.61e-03 |
| A tetrasaccharide linker sequence is required for GAG synthesis | 18 | 2.80e-02 | -0.299000 | 1.12e-01 |
| Resolution of Abasic Sites (AP sites) | 37 | 1.69e-03 | -0.298000 | 1.59e-02 |
| Gap junction trafficking | 14 | 5.40e-02 | -0.297000 | 1.74e-01 |
| FGFR2 alternative splicing | 25 | 1.01e-02 | -0.297000 | 5.65e-02 |
| Pre-NOTCH Processing in Golgi | 18 | 2.95e-02 | -0.296000 | 1.17e-01 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | 25 | 1.11e-02 | -0.293000 | 6.09e-02 |
| Translation of structural proteins | 28 | 7.25e-03 | -0.293000 | 4.58e-02 |
| Presynaptic phase of homologous DNA pairing and strand exchange | 39 | 1.55e-03 | 0.293000 | 1.50e-02 |
| Degradation of cysteine and homocysteine | 13 | 6.79e-02 | -0.292000 | 2.04e-01 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 22 | 1.81e-02 | -0.291000 | 8.64e-02 |
| The citric acid (TCA) cycle and respiratory electron transport | 172 | 4.51e-11 | -0.291000 | 1.43e-09 |
| Translocation of ZAP-70 to Immunological synapse | 24 | 1.42e-02 | -0.289000 | 7.26e-02 |
| PKA activation in glucagon signalling | 14 | 6.19e-02 | -0.288000 | 1.89e-01 |
| Heparan sulfate/heparin (HS-GAG) metabolism | 38 | 2.14e-03 | -0.288000 | 1.94e-02 |
| PKA activation | 15 | 5.37e-02 | -0.288000 | 1.74e-01 |
| Positive epigenetic regulation of rRNA expression | 62 | 9.44e-05 | -0.287000 | 1.36e-03 |
| Homologous DNA Pairing and Strand Exchange | 42 | 1.32e-03 | 0.286000 | 1.30e-02 |
| Glycogen metabolism | 23 | 1.76e-02 | -0.286000 | 8.52e-02 |
| RNA Polymerase I Promoter Clearance | 66 | 6.71e-05 | -0.284000 | 1.01e-03 |
| RNA Polymerase I Transcription | 66 | 6.71e-05 | -0.284000 | 1.01e-03 |
| Signaling by FGFR2 IIIa TM | 18 | 3.80e-02 | -0.282000 | 1.39e-01 |
| Lewis blood group biosynthesis | 13 | 7.88e-02 | -0.281000 | 2.25e-01 |
| ERKs are inactivated | 13 | 8.19e-02 | -0.279000 | 2.31e-01 |
| SHC-mediated cascade:FGFR1 | 12 | 9.51e-02 | 0.278000 | 2.51e-01 |
| Purine ribonucleoside monophosphate biosynthesis | 10 | 1.30e-01 | -0.276000 | 3.04e-01 |
| Plasma lipoprotein clearance | 29 | 1.01e-02 | -0.276000 | 5.65e-02 |
| Mitophagy | 28 | 1.16e-02 | -0.276000 | 6.29e-02 |
| Notch-HLH transcription pathway | 28 | 1.18e-02 | -0.275000 | 6.41e-02 |
| DNA Damage Recognition in GG-NER | 38 | 3.39e-03 | -0.275000 | 2.65e-02 |
| Suppression of phagosomal maturation | 12 | 9.99e-02 | -0.274000 | 2.55e-01 |
| Formation of the Early Elongation Complex | 33 | 6.58e-03 | -0.273000 | 4.21e-02 |
| Formation of the HIV-1 Early Elongation Complex | 33 | 6.58e-03 | -0.273000 | 4.21e-02 |
| Termination of O-glycan biosynthesis | 16 | 5.99e-02 | -0.272000 | 1.86e-01 |
| TRAF6 mediated IRF7 activation | 15 | 7.01e-02 | 0.270000 | 2.06e-01 |
| rRNA modification in the nucleus and cytosol | 59 | 3.99e-04 | -0.266000 | 4.74e-03 |
| SIRT1 negatively regulates rRNA expression | 24 | 2.39e-02 | -0.266000 | 1.02e-01 |
| Activation of SMO | 13 | 9.68e-02 | -0.266000 | 2.52e-01 |
| Synthesis of IP3 and IP4 in the cytosol | 22 | 3.09e-02 | -0.266000 | 1.20e-01 |
| Cellular responses to stress | 500 | 3.22e-24 | -0.265000 | 1.63e-22 |
| IRAK2 mediated activation of TAK1 complex | 10 | 1.47e-01 | -0.265000 | 3.30e-01 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 12 | 1.12e-01 | 0.265000 | 2.78e-01 |
| mitochondrial fatty acid beta-oxidation of saturated fatty acids | 11 | 1.30e-01 | -0.264000 | 3.04e-01 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | 28 | 1.63e-02 | -0.262000 | 8.06e-02 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | 16 | 6.96e-02 | -0.262000 | 2.06e-01 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | 14 | 9.12e-02 | -0.261000 | 2.43e-01 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | 14 | 9.12e-02 | -0.261000 | 2.43e-01 |
| p75NTR signals via NF-kB | 15 | 8.05e-02 | -0.261000 | 2.28e-01 |
| EPH-ephrin mediated repulsion of cells | 40 | 4.39e-03 | -0.260000 | 3.22e-02 |
| Signaling by FGFR1 in disease | 31 | 1.24e-02 | 0.260000 | 6.59e-02 |
| Cellular responses to external stimuli | 506 | 1.43e-23 | -0.260000 | 6.98e-22 |
| Downstream signaling of activated FGFR1 | 20 | 4.46e-02 | 0.259000 | 1.54e-01 |
| Prefoldin mediated transfer of substrate to CCT/TriC | 26 | 2.24e-02 | -0.259000 | 9.81e-02 |
| Processive synthesis on the C-strand of the telomere | 19 | 5.22e-02 | -0.257000 | 1.71e-01 |
| Deactivation of the beta-catenin transactivating complex | 36 | 7.71e-03 | -0.257000 | 4.81e-02 |
| Negative regulation of FGFR4 signaling | 21 | 4.20e-02 | -0.256000 | 1.48e-01 |
| Generation of second messenger molecules | 38 | 6.31e-03 | -0.256000 | 4.16e-02 |
| Elevation of cytosolic Ca2+ levels | 13 | 1.10e-01 | -0.256000 | 2.75e-01 |
| Neurexins and neuroligins | 38 | 6.35e-03 | -0.256000 | 4.16e-02 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | 27 | 2.15e-02 | -0.256000 | 9.55e-02 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 27 | 2.17e-02 | -0.255000 | 9.58e-02 |
| Signaling by cytosolic FGFR1 fusion mutants | 18 | 6.10e-02 | 0.255000 | 1.88e-01 |
| Chondroitin sulfate/dermatan sulfate metabolism | 39 | 6.02e-03 | -0.254000 | 4.05e-02 |
| Signaling by Leptin | 10 | 1.64e-01 | -0.254000 | 3.58e-01 |
| B-WICH complex positively regulates rRNA expression | 47 | 2.65e-03 | -0.253000 | 2.20e-02 |
| Synthesis of PE | 12 | 1.29e-01 | 0.253000 | 3.03e-01 |
| HATs acetylate histones | 93 | 2.51e-05 | -0.253000 | 4.04e-04 |
| Formation of HIV elongation complex in the absence of HIV Tat | 44 | 3.72e-03 | -0.253000 | 2.85e-02 |
| Mitochondrial calcium ion transport | 22 | 4.02e-02 | -0.253000 | 1.44e-01 |
| FGFR2 mutant receptor activation | 22 | 4.07e-02 | -0.252000 | 1.44e-01 |
| mRNA Splicing - Major Pathway | 179 | 6.15e-09 | -0.252000 | 1.71e-07 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | 64 | 5.26e-04 | -0.251000 | 5.93e-03 |
| Metabolism of nitric oxide: NOS3 activation and regulation | 12 | 1.33e-01 | -0.250000 | 3.09e-01 |
| PD-1 signaling | 28 | 2.21e-02 | -0.250000 | 9.70e-02 |
| Translesion synthesis by REV1 | 16 | 8.41e-02 | -0.249000 | 2.34e-01 |
| Translesion Synthesis by POLH | 18 | 6.95e-02 | -0.247000 | 2.06e-01 |
| mTORC1-mediated signalling | 23 | 4.05e-02 | -0.247000 | 1.44e-01 |
| RHO GTPases Activate NADPH Oxidases | 21 | 5.05e-02 | -0.246000 | 1.67e-01 |
| Pyrimidine salvage | 10 | 1.78e-01 | -0.246000 | 3.75e-01 |
| Ephrin signaling | 18 | 7.29e-02 | -0.244000 | 2.12e-01 |
| Phosphorylation of CD3 and TCR zeta chains | 27 | 2.82e-02 | -0.244000 | 1.13e-01 |
| NOTCH1 Intracellular Domain Regulates Transcription | 45 | 4.76e-03 | -0.243000 | 3.40e-02 |
| Collagen formation | 64 | 7.94e-04 | -0.242000 | 8.28e-03 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | 32 | 1.77e-02 | 0.242000 | 8.52e-02 |
| FRS-mediated FGFR1 signaling | 14 | 1.17e-01 | 0.242000 | 2.83e-01 |
| RIPK1-mediated regulated necrosis | 16 | 9.36e-02 | 0.242000 | 2.48e-01 |
| Regulated Necrosis | 16 | 9.36e-02 | 0.242000 | 2.48e-01 |
| Amyloid fiber formation | 51 | 2.79e-03 | -0.242000 | 2.26e-02 |
| Lysosome Vesicle Biogenesis | 32 | 1.80e-02 | -0.242000 | 8.62e-02 |
| PCP/CE pathway | 87 | 9.89e-05 | -0.241000 | 1.41e-03 |
| RNA Polymerase I Promoter Escape | 47 | 4.39e-03 | -0.240000 | 3.22e-02 |
| HS-GAG degradation | 16 | 9.64e-02 | -0.240000 | 2.52e-01 |
| Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane | 11 | 1.70e-01 | -0.239000 | 3.63e-01 |
| Axon guidance | 459 | 1.66e-18 | -0.239000 | 7.06e-17 |
| Condensation of Prophase Chromosomes | 29 | 2.60e-02 | -0.239000 | 1.07e-01 |
| PCNA-Dependent Long Patch Base Excision Repair | 21 | 5.84e-02 | -0.239000 | 1.83e-01 |
| Maturation of nucleoprotein | 10 | 1.91e-01 | 0.239000 | 3.92e-01 |
| RNA Pol II CTD phosphorylation and interaction with CE | 27 | 3.20e-02 | -0.238000 | 1.22e-01 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 27 | 3.20e-02 | -0.238000 | 1.22e-01 |
| TGF-beta receptor signaling activates SMADs | 32 | 1.96e-02 | -0.238000 | 9.04e-02 |
| Glutamate and glutamine metabolism | 12 | 1.53e-01 | -0.238000 | 3.40e-01 |
| RNA Polymerase I Transcription Initiation | 47 | 4.71e-03 | -0.238000 | 3.38e-02 |
| Chemokine receptors bind chemokines | 40 | 9.29e-03 | -0.238000 | 5.39e-02 |
| Formation of TC-NER Pre-Incision Complex | 53 | 2.77e-03 | -0.238000 | 2.26e-02 |
| Metabolism of RNA | 688 | 2.60e-26 | -0.237000 | 1.48e-24 |
| Serotonin Neurotransmitter Release Cycle | 14 | 1.25e-01 | -0.237000 | 2.97e-01 |
| Budding and maturation of HIV virion | 26 | 3.67e-02 | -0.237000 | 1.35e-01 |
| Nuclear Receptor transcription pathway | 41 | 8.81e-03 | -0.236000 | 5.22e-02 |
| HDR through Single Strand Annealing (SSA) | 37 | 1.29e-02 | 0.236000 | 6.75e-02 |
| Metabolism of amino acids and derivatives | 326 | 2.84e-13 | -0.235000 | 9.67e-12 |
| Processing of SMDT1 | 15 | 1.15e-01 | -0.235000 | 2.83e-01 |
| Polymerase switching on the C-strand of the telomere | 26 | 3.92e-02 | -0.234000 | 1.43e-01 |
| Nervous system development | 478 | 1.98e-18 | -0.234000 | 8.18e-17 |
| Regulation of IFNG signaling | 14 | 1.30e-01 | 0.233000 | 3.04e-01 |
| Regulation of TP53 Activity through Methylation | 19 | 7.89e-02 | -0.233000 | 2.25e-01 |
| IRAK4 deficiency (TLR2/4) | 10 | 2.03e-01 | 0.232000 | 4.03e-01 |
| MyD88 deficiency (TLR2/4) | 10 | 2.03e-01 | 0.232000 | 4.03e-01 |
| mRNA Splicing | 187 | 4.42e-08 | -0.232000 | 1.14e-06 |
| Removal of the Flap Intermediate from the C-strand | 17 | 9.77e-02 | -0.232000 | 2.54e-01 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 24 | 5.02e-02 | -0.231000 | 1.67e-01 |
| FGFR1 mutant receptor activation | 24 | 5.05e-02 | 0.231000 | 1.67e-01 |
| Telomere C-strand (Lagging Strand) Synthesis | 34 | 2.07e-02 | -0.229000 | 9.30e-02 |
| Signaling by PDGFRA extracellular domain mutants | 12 | 1.71e-01 | 0.228000 | 3.65e-01 |
| Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 12 | 1.71e-01 | 0.228000 | 3.65e-01 |
| IRE1alpha activates chaperones | 49 | 5.71e-03 | -0.228000 | 3.90e-02 |
| Negative regulation of FGFR3 signaling | 20 | 7.75e-02 | -0.228000 | 2.22e-01 |
| PKA-mediated phosphorylation of CREB | 17 | 1.04e-01 | -0.228000 | 2.62e-01 |
| Detoxification of Reactive Oxygen Species | 32 | 2.57e-02 | -0.228000 | 1.07e-01 |
| Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 11 | 1.91e-01 | 0.228000 | 3.92e-01 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 29 | 3.44e-02 | -0.227000 | 1.28e-01 |
| FRS-mediated FGFR3 signaling | 11 | 1.93e-01 | 0.227000 | 3.93e-01 |
| Resolution of D-Loop Structures | 33 | 2.42e-02 | 0.227000 | 1.03e-01 |
| Metabolism of amine-derived hormones | 10 | 2.15e-01 | 0.226000 | 4.14e-01 |
| IRF3-mediated induction of type I IFN | 12 | 1.75e-01 | -0.226000 | 3.71e-01 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 35 | 2.07e-02 | -0.226000 | 9.30e-02 |
| Early Phase of HIV Life Cycle | 14 | 1.43e-01 | -0.226000 | 3.26e-01 |
| Mitochondrial iron-sulfur cluster biogenesis | 13 | 1.59e-01 | -0.226000 | 3.49e-01 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 78 | 5.83e-04 | -0.225000 | 6.52e-03 |
| Glycosaminoglycan metabolism | 93 | 1.93e-04 | -0.224000 | 2.52e-03 |
| Signal regulatory protein family interactions | 12 | 1.81e-01 | -0.223000 | 3.79e-01 |
| Chromatin modifying enzymes | 218 | 1.41e-08 | -0.223000 | 3.70e-07 |
| Chromatin organization | 218 | 1.41e-08 | -0.223000 | 3.70e-07 |
| Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | 10 | 2.25e-01 | 0.222000 | 4.26e-01 |
| Vitamin D (calciferol) metabolism | 10 | 2.27e-01 | -0.221000 | 4.28e-01 |
| AKT phosphorylates targets in the cytosol | 14 | 1.53e-01 | -0.221000 | 3.40e-01 |
| Extension of Telomeres | 51 | 6.42e-03 | -0.221000 | 4.19e-02 |
| Protein localization | 157 | 1.83e-06 | -0.221000 | 3.84e-05 |
| Activated NOTCH1 Transmits Signal to the Nucleus | 27 | 4.92e-02 | -0.219000 | 1.64e-01 |
| Pregnenolone biosynthesis | 10 | 2.32e-01 | -0.218000 | 4.34e-01 |
| Nephrin family interactions | 18 | 1.09e-01 | -0.218000 | 2.74e-01 |
| Other semaphorin interactions | 16 | 1.31e-01 | -0.218000 | 3.06e-01 |
| XBP1(S) activates chaperone genes | 47 | 9.99e-03 | -0.217000 | 5.64e-02 |
| TRP channels | 19 | 1.02e-01 | 0.217000 | 2.58e-01 |
| GAB1 signalosome | 15 | 1.46e-01 | -0.217000 | 3.29e-01 |
| Signaling by FGFR3 in disease | 13 | 1.77e-01 | 0.216000 | 3.73e-01 |
| Signaling by FGFR3 point mutants in cancer | 13 | 1.77e-01 | 0.216000 | 3.73e-01 |
| Endosomal/Vacuolar pathway | 12 | 1.95e-01 | -0.216000 | 3.94e-01 |
| Caspase-mediated cleavage of cytoskeletal proteins | 12 | 1.95e-01 | -0.216000 | 3.94e-01 |
| Aggrephagy | 22 | 7.98e-02 | -0.216000 | 2.27e-01 |
| Metabolism of carbohydrates | 242 | 7.34e-09 | -0.216000 | 2.00e-07 |
| SHC-mediated cascade:FGFR2 | 12 | 1.97e-01 | 0.215000 | 3.96e-01 |
| UCH proteinases | 87 | 5.24e-04 | -0.215000 | 5.93e-03 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | 23 | 7.42e-02 | -0.215000 | 2.15e-01 |
| Estrogen-dependent gene expression | 99 | 2.20e-04 | -0.215000 | 2.80e-03 |
| Negative epigenetic regulation of rRNA expression | 65 | 2.85e-03 | -0.214000 | 2.29e-02 |
| PI-3K cascade:FGFR1 | 12 | 2.00e-01 | 0.214000 | 3.99e-01 |
| Regulation of RUNX1 Expression and Activity | 18 | 1.17e-01 | 0.214000 | 2.83e-01 |
| Synthesis of PIPs at the early endosome membrane | 16 | 1.39e-01 | 0.214000 | 3.19e-01 |
| HS-GAG biosynthesis | 20 | 9.83e-02 | -0.214000 | 2.54e-01 |
| Downstream signaling of activated FGFR3 | 16 | 1.40e-01 | 0.213000 | 3.20e-01 |
| TCF dependent signaling in response to WNT | 167 | 2.14e-06 | -0.213000 | 4.43e-05 |
| Establishment of Sister Chromatid Cohesion | 11 | 2.23e-01 | 0.212000 | 4.25e-01 |
| GP1b-IX-V activation signalling | 10 | 2.45e-01 | -0.212000 | 4.50e-01 |
| Response of Mtb to phagocytosis | 22 | 8.52e-02 | -0.212000 | 2.34e-01 |
| Processing of Capped Intronless Pre-mRNA | 28 | 5.29e-02 | -0.211000 | 1.73e-01 |
| Infectious disease | 725 | 3.39e-22 | -0.211000 | 1.60e-20 |
| ERBB2 Regulates Cell Motility | 10 | 2.48e-01 | -0.211000 | 4.52e-01 |
| Signaling by PDGFR in disease | 19 | 1.12e-01 | 0.210000 | 2.78e-01 |
| Interleukin-7 signaling | 21 | 9.54e-02 | -0.210000 | 2.51e-01 |
| Interconversion of nucleotide di- and triphosphates | 27 | 5.96e-02 | -0.209000 | 1.85e-01 |
| NoRC negatively regulates rRNA expression | 62 | 4.37e-03 | -0.209000 | 3.22e-02 |
| Assembly of collagen fibrils and other multimeric structures | 42 | 1.93e-02 | -0.209000 | 8.95e-02 |
| RAS processing | 19 | 1.16e-01 | -0.209000 | 2.83e-01 |
| Synaptic adhesion-like molecules | 16 | 1.49e-01 | -0.208000 | 3.33e-01 |
| Transcriptional regulation by small RNAs | 63 | 4.22e-03 | -0.208000 | 3.18e-02 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | 20 | 1.07e-01 | -0.208000 | 2.70e-01 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 12 | 2.13e-01 | 0.208000 | 4.11e-01 |
| Gap junction trafficking and regulation | 16 | 1.52e-01 | -0.207000 | 3.39e-01 |
| mRNA decay by 5' to 3' exoribonuclease | 15 | 1.66e-01 | -0.207000 | 3.60e-01 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | 15 | 1.67e-01 | -0.206000 | 3.60e-01 |
| Telomere C-strand synthesis initiation | 13 | 1.99e-01 | -0.206000 | 3.98e-01 |
| Nucleotide Excision Repair | 110 | 2.03e-04 | -0.205000 | 2.61e-03 |
| Regulation of innate immune responses to cytosolic DNA | 14 | 1.85e-01 | -0.205000 | 3.85e-01 |
| Chondroitin sulfate biosynthesis | 13 | 2.02e-01 | -0.204000 | 4.02e-01 |
| Telomere Extension By Telomerase | 23 | 9.07e-02 | -0.204000 | 2.43e-01 |
| Regulation of FOXO transcriptional activity by acetylation | 10 | 2.68e-01 | -0.202000 | 4.70e-01 |
| Antiviral mechanism by IFN-stimulated genes | 80 | 1.78e-03 | 0.202000 | 1.66e-02 |
| Dual incision in TC-NER | 65 | 4.93e-03 | -0.202000 | 3.49e-02 |
| Oxidative Stress Induced Senescence | 79 | 1.98e-03 | -0.201000 | 1.83e-02 |
| Glycogen breakdown (glycogenolysis) | 13 | 2.11e-01 | -0.201000 | 4.10e-01 |
| Signaling by EGFR | 46 | 1.87e-02 | -0.200000 | 8.75e-02 |
| Sulfur amino acid metabolism | 23 | 9.67e-02 | -0.200000 | 2.52e-01 |
| Common Pathway of Fibrin Clot Formation | 14 | 1.95e-01 | -0.200000 | 3.94e-01 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | 54 | 1.10e-02 | -0.200000 | 6.06e-02 |
| Defective B3GAT3 causes JDSSDHD | 12 | 2.31e-01 | -0.200000 | 4.33e-01 |
| CaM pathway | 27 | 7.46e-02 | -0.198000 | 2.15e-01 |
| Calmodulin induced events | 27 | 7.46e-02 | -0.198000 | 2.15e-01 |
| Signaling by NOTCH1 | 67 | 5.03e-03 | -0.198000 | 3.52e-02 |
| Other interleukin signaling | 18 | 1.46e-01 | -0.198000 | 3.29e-01 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | 12 | 2.36e-01 | -0.197000 | 4.39e-01 |
| MET activates RAS signaling | 10 | 2.81e-01 | 0.197000 | 4.81e-01 |
| InlB-mediated entry of Listeria monocytogenes into host cell | 12 | 2.39e-01 | -0.196000 | 4.42e-01 |
| Nucleotide salvage | 21 | 1.21e-01 | -0.195000 | 2.91e-01 |
| Amino acids regulate mTORC1 | 50 | 1.75e-02 | -0.194000 | 8.50e-02 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 17 | 1.66e-01 | -0.194000 | 3.60e-01 |
| Processive synthesis on the lagging strand | 15 | 1.95e-01 | -0.193000 | 3.94e-01 |
| Dopamine Neurotransmitter Release Cycle | 19 | 1.45e-01 | -0.193000 | 3.29e-01 |
| Hyaluronan metabolism | 13 | 2.28e-01 | -0.193000 | 4.31e-01 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 17 | 1.69e-01 | -0.193000 | 3.63e-01 |
| Negative regulation of FGFR2 signaling | 23 | 1.10e-01 | -0.192000 | 2.76e-01 |
| Downregulation of TGF-beta receptor signaling | 26 | 9.08e-02 | -0.192000 | 2.43e-01 |
| Chromosome Maintenance | 105 | 6.93e-04 | -0.192000 | 7.69e-03 |
| Keratan sulfate biosynthesis | 22 | 1.20e-01 | -0.191000 | 2.90e-01 |
| Translesion synthesis by POLI | 17 | 1.72e-01 | -0.191000 | 3.68e-01 |
| Biosynthesis of DHA-derived SPMs | 14 | 2.16e-01 | -0.191000 | 4.15e-01 |
| Costimulation by the CD28 family | 74 | 4.57e-03 | -0.191000 | 3.30e-02 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | 46 | 2.54e-02 | -0.190000 | 1.06e-01 |
| Metabolism of nucleotides | 86 | 2.28e-03 | -0.190000 | 2.00e-02 |
| Signaling by NODAL | 13 | 2.35e-01 | -0.190000 | 4.38e-01 |
| E3 ubiquitin ligases ubiquitinate target proteins | 52 | 1.80e-02 | -0.190000 | 8.62e-02 |
| ERK/MAPK targets | 22 | 1.24e-01 | -0.189000 | 2.95e-01 |
| HCMV Late Events | 69 | 6.56e-03 | -0.189000 | 4.21e-02 |
| SARS-CoV-1 Infection | 47 | 2.49e-02 | -0.189000 | 1.05e-01 |
| MECP2 regulates neuronal receptors and channels | 13 | 2.38e-01 | -0.189000 | 4.41e-01 |
| FRS-mediated FGFR2 signaling | 14 | 2.23e-01 | 0.188000 | 4.25e-01 |
| Developmental Biology | 738 | 3.16e-18 | -0.188000 | 1.27e-16 |
| Regulation of necroptotic cell death | 14 | 2.24e-01 | 0.188000 | 4.25e-01 |
| Interleukin-27 signaling | 11 | 2.81e-01 | 0.188000 | 4.81e-01 |
| Interferon Signaling | 177 | 1.65e-05 | 0.188000 | 2.86e-04 |
| Cellular Senescence | 144 | 1.03e-04 | -0.187000 | 1.45e-03 |
| Downstream signaling of activated FGFR2 | 19 | 1.58e-01 | 0.187000 | 3.48e-01 |
| Long-term potentiation | 15 | 2.11e-01 | -0.187000 | 4.10e-01 |
| Protein-protein interactions at synapses | 59 | 1.35e-02 | -0.186000 | 6.99e-02 |
| Host Interactions of HIV factors | 130 | 2.65e-04 | -0.185000 | 3.35e-03 |
| Degradation of beta-catenin by the destruction complex | 84 | 3.38e-03 | -0.185000 | 2.65e-02 |
| Ca-dependent events | 29 | 8.50e-02 | -0.185000 | 2.34e-01 |
| RNA Polymerase III Transcription Initiation | 36 | 5.63e-02 | -0.184000 | 1.77e-01 |
| Inositol phosphate metabolism | 43 | 3.81e-02 | -0.183000 | 1.39e-01 |
| Vpu mediated degradation of CD4 | 51 | 2.44e-02 | -0.182000 | 1.03e-01 |
| Activation of HOX genes during differentiation | 71 | 7.96e-03 | -0.182000 | 4.91e-02 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | 71 | 7.96e-03 | -0.182000 | 4.91e-02 |
| Asymmetric localization of PCP proteins | 61 | 1.39e-02 | -0.182000 | 7.12e-02 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 10 | 3.19e-01 | -0.182000 | 5.21e-01 |
| Scavenging by Class A Receptors | 12 | 2.76e-01 | 0.182000 | 4.78e-01 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | 25 | 1.16e-01 | -0.182000 | 2.83e-01 |
| p75NTR recruits signalling complexes | 12 | 2.78e-01 | -0.181000 | 4.79e-01 |
| Processing of Capped Intron-Containing Pre-mRNA | 238 | 1.60e-06 | -0.181000 | 3.42e-05 |
| Interaction between L1 and Ankyrins | 22 | 1.44e-01 | 0.180000 | 3.27e-01 |
| Protein ubiquitination | 72 | 8.32e-03 | -0.180000 | 5.03e-02 |
| ABC transporter disorders | 71 | 8.87e-03 | -0.180000 | 5.22e-02 |
| Degradation of DVL | 55 | 2.15e-02 | -0.179000 | 9.55e-02 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 24 | 1.30e-01 | -0.179000 | 3.04e-01 |
| Regulation of TP53 Expression and Degradation | 36 | 6.36e-02 | -0.179000 | 1.93e-01 |
| Epigenetic regulation of gene expression | 103 | 1.79e-03 | -0.178000 | 1.67e-02 |
| Signaling by FGFR2 | 60 | 1.72e-02 | -0.178000 | 8.41e-02 |
| PTEN Regulation | 139 | 3.01e-04 | -0.178000 | 3.70e-03 |
| Purine salvage | 12 | 2.87e-01 | -0.177000 | 4.89e-01 |
| Translesion synthesis by POLK | 17 | 2.06e-01 | -0.177000 | 4.05e-01 |
| Insulin receptor recycling | 21 | 1.60e-01 | -0.177000 | 3.50e-01 |
| Hedgehog 'off' state | 93 | 3.20e-03 | -0.177000 | 2.54e-02 |
| DNA Damage/Telomere Stress Induced Senescence | 44 | 4.24e-02 | -0.177000 | 1.49e-01 |
| Nuclear Events (kinase and transcription factor activation) | 55 | 2.38e-02 | -0.176000 | 1.02e-01 |
| Response of EIF2AK1 (HRI) to heme deficiency | 14 | 2.54e-01 | 0.176000 | 4.54e-01 |
| Ubiquitin-dependent degradation of Cyclin D | 51 | 2.97e-02 | -0.176000 | 1.17e-01 |
| Dectin-1 mediated noncanonical NF-kB signaling | 60 | 1.85e-02 | -0.176000 | 8.72e-02 |
| Adenylate cyclase inhibitory pathway | 11 | 3.14e-01 | -0.175000 | 5.19e-01 |
| Uptake and actions of bacterial toxins | 27 | 1.15e-01 | -0.175000 | 2.83e-01 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | 53 | 2.73e-02 | -0.175000 | 1.10e-01 |
| Signaling by NOTCH | 183 | 4.35e-05 | -0.175000 | 6.74e-04 |
| Regulation of TP53 Degradation | 35 | 7.34e-02 | -0.175000 | 2.13e-01 |
| Downstream TCR signaling | 101 | 2.40e-03 | -0.175000 | 2.07e-02 |
| Selective autophagy | 59 | 2.07e-02 | -0.174000 | 9.30e-02 |
| DNA Double Strand Break Response | 47 | 3.93e-02 | -0.174000 | 1.43e-01 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 184 | 4.87e-05 | -0.174000 | 7.47e-04 |
| Autodegradation of the E3 ubiquitin ligase COP1 | 50 | 3.39e-02 | -0.173000 | 1.27e-01 |
| Signaling by TGF-beta Receptor Complex | 72 | 1.11e-02 | -0.173000 | 6.06e-02 |
| Formation of RNA Pol II elongation complex | 57 | 2.38e-02 | -0.173000 | 1.02e-01 |
| RNA Polymerase II Transcription Elongation | 57 | 2.38e-02 | -0.173000 | 1.02e-01 |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | 27 | 1.20e-01 | -0.173000 | 2.89e-01 |
| CD28 co-stimulation | 33 | 8.58e-02 | -0.173000 | 2.35e-01 |
| ESR-mediated signaling | 161 | 1.67e-04 | -0.172000 | 2.24e-03 |
| Resolution of Sister Chromatid Cohesion | 104 | 2.46e-03 | 0.172000 | 2.08e-02 |
| Keratan sulfate/keratin metabolism | 27 | 1.22e-01 | -0.172000 | 2.93e-01 |
| Formation of tubulin folding intermediates by CCT/TriC | 22 | 1.63e-01 | -0.172000 | 3.56e-01 |
| Signaling by WNT | 255 | 2.40e-06 | -0.171000 | 4.75e-05 |
| DCC mediated attractive signaling | 13 | 2.84e-01 | -0.171000 | 4.85e-01 |
| Nuclear signaling by ERBB4 | 24 | 1.46e-01 | -0.171000 | 3.29e-01 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 31 | 9.90e-02 | -0.171000 | 2.54e-01 |
| Cytosolic tRNA aminoacylation | 24 | 1.47e-01 | 0.171000 | 3.30e-01 |
| FOXO-mediated transcription of cell cycle genes | 15 | 2.52e-01 | -0.171000 | 4.52e-01 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | 83 | 7.22e-03 | -0.171000 | 4.58e-02 |
| Pre-NOTCH Expression and Processing | 65 | 1.75e-02 | -0.170000 | 8.50e-02 |
| TRAF3-dependent IRF activation pathway | 13 | 2.88e-01 | 0.170000 | 4.89e-01 |
| NGF-stimulated transcription | 33 | 9.11e-02 | -0.170000 | 2.43e-01 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 14 | 2.71e-01 | -0.170000 | 4.74e-01 |
| Intraflagellar transport | 39 | 6.69e-02 | -0.170000 | 2.02e-01 |
| TCR signaling | 122 | 1.22e-03 | -0.170000 | 1.21e-02 |
| RNA Polymerase II Transcription Termination | 65 | 1.84e-02 | -0.169000 | 8.72e-02 |
| GLI3 is processed to GLI3R by the proteasome | 58 | 2.61e-02 | -0.169000 | 1.07e-01 |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | 34 | 8.85e-02 | -0.169000 | 2.40e-01 |
| ADORA2B mediated anti-inflammatory cytokines production | 74 | 1.22e-02 | -0.168000 | 6.56e-02 |
| NIK-->noncanonical NF-kB signaling | 58 | 2.66e-02 | -0.168000 | 1.09e-01 |
| mRNA Capping | 29 | 1.17e-01 | -0.168000 | 2.84e-01 |
| Cell-extracellular matrix interactions | 14 | 2.76e-01 | -0.168000 | 4.78e-01 |
| Mitochondrial biogenesis | 89 | 6.28e-03 | -0.168000 | 4.16e-02 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | 91 | 5.95e-03 | 0.167000 | 4.02e-02 |
| Amplification of signal from the kinetochores | 91 | 5.95e-03 | 0.167000 | 4.02e-02 |
| Voltage gated Potassium channels | 27 | 1.34e-01 | -0.167000 | 3.11e-01 |
| Autophagy | 125 | 1.29e-03 | -0.167000 | 1.28e-02 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | 20 | 1.99e-01 | -0.166000 | 3.98e-01 |
| Trafficking of AMPA receptors | 20 | 1.99e-01 | -0.166000 | 3.98e-01 |
| LDL clearance | 17 | 2.36e-01 | -0.166000 | 4.39e-01 |
| Signaling by Nuclear Receptors | 219 | 2.35e-05 | -0.166000 | 3.82e-04 |
| MyD88 cascade initiated on plasma membrane | 82 | 9.58e-03 | -0.165000 | 5.50e-02 |
| Toll Like Receptor 10 (TLR10) Cascade | 82 | 9.58e-03 | -0.165000 | 5.50e-02 |
| Toll Like Receptor 5 (TLR5) Cascade | 82 | 9.58e-03 | -0.165000 | 5.50e-02 |
| Regulation of KIT signaling | 15 | 2.67e-01 | -0.165000 | 4.70e-01 |
| Protein methylation | 15 | 2.67e-01 | -0.165000 | 4.70e-01 |
| Erythrocytes take up carbon dioxide and release oxygen | 11 | 3.43e-01 | -0.165000 | 5.46e-01 |
| O2/CO2 exchange in erythrocytes | 11 | 3.43e-01 | -0.165000 | 5.46e-01 |
| Tight junction interactions | 19 | 2.13e-01 | -0.165000 | 4.11e-01 |
| Beta-catenin phosphorylation cascade | 17 | 2.39e-01 | -0.165000 | 4.41e-01 |
| Signaling by NOTCH3 | 43 | 6.14e-02 | -0.165000 | 1.88e-01 |
| Blood group systems biosynthesis | 17 | 2.40e-01 | -0.165000 | 4.42e-01 |
| Association of TriC/CCT with target proteins during biosynthesis | 37 | 8.46e-02 | -0.164000 | 2.34e-01 |
| G-protein mediated events | 44 | 6.05e-02 | -0.164000 | 1.86e-01 |
| Signaling by EGFR in Cancer | 23 | 1.75e-01 | -0.164000 | 3.71e-01 |
| PI3K events in ERBB2 signaling | 11 | 3.48e-01 | -0.164000 | 5.51e-01 |
| Autodegradation of Cdh1 by Cdh1:APC/C | 64 | 2.37e-02 | -0.163000 | 1.02e-01 |
| E2F mediated regulation of DNA replication | 22 | 1.85e-01 | 0.163000 | 3.84e-01 |
| Vif-mediated degradation of APOBEC3G | 53 | 4.04e-02 | -0.163000 | 1.44e-01 |
| Effects of PIP2 hydrolysis | 24 | 1.68e-01 | -0.163000 | 3.61e-01 |
| SHC-mediated cascade:FGFR4 | 10 | 3.74e-01 | 0.162000 | 5.77e-01 |
| Keratinization | 34 | 1.01e-01 | -0.162000 | 2.58e-01 |
| TP53 Regulates Transcription of DNA Repair Genes | 61 | 2.84e-02 | -0.162000 | 1.13e-01 |
| Gastrin-CREB signalling pathway via PKC and MAPK | 14 | 2.94e-01 | -0.162000 | 4.96e-01 |
| Activation of kainate receptors upon glutamate binding | 26 | 1.54e-01 | -0.161000 | 3.42e-01 |
| Biosynthesis of specialized proresolving mediators (SPMs) | 16 | 2.65e-01 | -0.161000 | 4.69e-01 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 30 | 1.27e-01 | -0.161000 | 3.00e-01 |
| Signaling by Hippo | 18 | 2.38e-01 | 0.161000 | 4.41e-01 |
| Defective CFTR causes cystic fibrosis | 60 | 3.15e-02 | -0.160000 | 1.22e-01 |
| ROS and RNS production in phagocytes | 31 | 1.23e-01 | -0.160000 | 2.93e-01 |
| SUMOylation of transcription cofactors | 44 | 6.63e-02 | -0.160000 | 2.01e-01 |
| Carnitine metabolism | 10 | 3.82e-01 | -0.160000 | 5.83e-01 |
| Activation of NF-kappaB in B cells | 66 | 2.48e-02 | -0.160000 | 1.04e-01 |
| FOXO-mediated transcription | 59 | 3.38e-02 | -0.160000 | 1.27e-01 |
| PLC beta mediated events | 43 | 7.01e-02 | -0.160000 | 2.06e-01 |
| Regulation of PTEN mRNA translation | 13 | 3.20e-01 | 0.159000 | 5.23e-01 |
| DAG and IP3 signaling | 33 | 1.14e-01 | -0.159000 | 2.82e-01 |
| Macroautophagy | 111 | 3.85e-03 | -0.159000 | 2.94e-02 |
| Intracellular signaling by second messengers | 273 | 6.31e-06 | -0.159000 | 1.21e-04 |
| PI3K/AKT Signaling in Cancer | 81 | 1.39e-02 | -0.158000 | 7.12e-02 |
| RAF-independent MAPK1/3 activation | 21 | 2.10e-01 | -0.158000 | 4.10e-01 |
| CRMPs in Sema3A signaling | 14 | 3.06e-01 | -0.158000 | 5.15e-01 |
| HCMV Infection | 96 | 7.56e-03 | -0.158000 | 4.73e-02 |
| Regulation of signaling by CBL | 18 | 2.47e-01 | -0.158000 | 4.51e-01 |
| Transcriptional regulation of pluripotent stem cells | 21 | 2.11e-01 | 0.158000 | 4.10e-01 |
| ABC transporters in lipid homeostasis | 14 | 3.08e-01 | -0.157000 | 5.15e-01 |
| Signaling by Hedgehog | 121 | 2.80e-03 | -0.157000 | 2.26e-02 |
| Removal of the Flap Intermediate | 14 | 3.08e-01 | -0.157000 | 5.15e-01 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | 49 | 5.84e-02 | -0.156000 | 1.83e-01 |
| Beta-catenin independent WNT signaling | 137 | 1.59e-03 | -0.156000 | 1.52e-02 |
| NR1H2 and NR1H3-mediated signaling | 40 | 8.86e-02 | -0.156000 | 2.40e-01 |
| Hh mutants abrogate ligand secretion | 55 | 4.60e-02 | -0.156000 | 1.57e-01 |
| PIP3 activates AKT signaling | 241 | 3.19e-05 | -0.156000 | 5.06e-04 |
| Degradation of AXIN | 54 | 4.83e-02 | -0.155000 | 1.63e-01 |
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 51 | 5.50e-02 | -0.155000 | 1.74e-01 |
| p53-Independent DNA Damage Response | 51 | 5.50e-02 | -0.155000 | 1.74e-01 |
| p53-Independent G1/S DNA damage checkpoint | 51 | 5.50e-02 | -0.155000 | 1.74e-01 |
| Negative regulation of NOTCH4 signaling | 54 | 4.89e-02 | -0.155000 | 1.64e-01 |
| Degradation of GLI2 by the proteasome | 57 | 4.33e-02 | -0.155000 | 1.51e-01 |
| Metabolism of Angiotensinogen to Angiotensins | 11 | 3.75e-01 | -0.154000 | 5.79e-01 |
| Phase 2 - plateau phase | 17 | 2.71e-01 | 0.154000 | 4.73e-01 |
| Plasma lipoprotein assembly, remodeling, and clearance | 54 | 5.00e-02 | -0.154000 | 1.66e-01 |
| Transcriptional Regulation by MECP2 | 47 | 6.79e-02 | -0.154000 | 2.04e-01 |
| Pre-NOTCH Transcription and Translation | 49 | 6.25e-02 | -0.154000 | 1.90e-01 |
| Hedgehog 'on' state | 76 | 2.06e-02 | -0.154000 | 9.30e-02 |
| Cyclin A/B1/B2 associated events during G2/M transition | 24 | 1.94e-01 | 0.153000 | 3.94e-01 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | 29 | 1.54e-01 | -0.153000 | 3.41e-01 |
| Downstream signaling of activated FGFR4 | 17 | 2.77e-01 | 0.152000 | 4.78e-01 |
| NRIF signals cell death from the nucleus | 15 | 3.07e-01 | -0.152000 | 5.15e-01 |
| tRNA processing | 136 | 2.22e-03 | -0.152000 | 1.98e-02 |
| Metabolism | 1771 | 4.10e-26 | -0.151000 | 2.24e-24 |
| Disease | 1302 | 5.00e-20 | -0.151000 | 2.20e-18 |
| RNA Polymerase III Transcription Termination | 23 | 2.10e-01 | -0.151000 | 4.10e-01 |
| PI-3K cascade:FGFR2 | 12 | 3.65e-01 | 0.151000 | 5.70e-01 |
| ISG15 antiviral mechanism | 72 | 2.69e-02 | 0.151000 | 1.09e-01 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 54 | 5.51e-02 | -0.151000 | 1.74e-01 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | 54 | 5.51e-02 | -0.151000 | 1.74e-01 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 54 | 5.51e-02 | -0.151000 | 1.74e-01 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | 54 | 5.51e-02 | -0.151000 | 1.74e-01 |
| Signaling by NOTCH1 in Cancer | 54 | 5.51e-02 | -0.151000 | 1.74e-01 |
| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD | 54 | 5.52e-02 | -0.151000 | 1.74e-01 |
| Regulation of RUNX3 expression and activity | 55 | 5.32e-02 | -0.151000 | 1.73e-01 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 19 | 2.56e-01 | -0.150000 | 4.57e-01 |
| Assembly and cell surface presentation of NMDA receptors | 19 | 2.57e-01 | -0.150000 | 4.57e-01 |
| NS1 Mediated Effects on Host Pathways | 40 | 1.00e-01 | 0.150000 | 2.55e-01 |
| Cell-Cell communication | 88 | 1.50e-02 | -0.150000 | 7.54e-02 |
| GABA synthesis, release, reuptake and degradation | 13 | 3.49e-01 | -0.150000 | 5.52e-01 |
| Gene Silencing by RNA | 88 | 1.51e-02 | -0.150000 | 7.59e-02 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | 36 | 1.20e-01 | -0.150000 | 2.89e-01 |
| Activation of BAD and translocation to mitochondria | 15 | 3.16e-01 | -0.150000 | 5.19e-01 |
| Cellular response to heat stress | 93 | 1.27e-02 | -0.150000 | 6.67e-02 |
| SCF-beta-TrCP mediated degradation of Emi1 | 54 | 5.76e-02 | -0.149000 | 1.81e-01 |
| Lysosphingolipid and LPA receptors | 11 | 3.92e-01 | -0.149000 | 5.89e-01 |
| Calnexin/calreticulin cycle | 26 | 1.89e-01 | -0.149000 | 3.90e-01 |
| HIV Infection | 225 | 1.26e-04 | -0.148000 | 1.73e-03 |
| mRNA decay by 3' to 5' exoribonuclease | 16 | 3.05e-01 | -0.148000 | 5.13e-01 |
| TNFR2 non-canonical NF-kB pathway | 96 | 1.23e-02 | -0.148000 | 6.56e-02 |
| Presynaptic function of Kainate receptors | 18 | 2.79e-01 | -0.147000 | 4.79e-01 |
| EML4 and NUDC in mitotic spindle formation | 95 | 1.32e-02 | 0.147000 | 6.87e-02 |
| Cytosolic sensors of pathogen-associated DNA | 62 | 4.61e-02 | -0.146000 | 1.57e-01 |
| Defective B4GALT7 causes EDS, progeroid type | 12 | 3.81e-01 | -0.146000 | 5.83e-01 |
| Regulation of MECP2 expression and activity | 28 | 1.81e-01 | -0.146000 | 3.79e-01 |
| Recognition of DNA damage by PCNA-containing replication complex | 30 | 1.66e-01 | -0.146000 | 3.60e-01 |
| Diseases associated with glycosaminoglycan metabolism | 27 | 1.89e-01 | -0.146000 | 3.90e-01 |
| Sema3A PAK dependent Axon repulsion | 16 | 3.14e-01 | -0.145000 | 5.19e-01 |
| TRAF6 mediated NF-kB activation | 23 | 2.28e-01 | -0.145000 | 4.31e-01 |
| Nicotinamide salvaging | 15 | 3.31e-01 | 0.145000 | 5.34e-01 |
| Lysine catabolism | 11 | 4.06e-01 | 0.145000 | 6.03e-01 |
| Diseases of programmed cell death | 22 | 2.40e-01 | -0.145000 | 4.42e-01 |
| Signaling by the B Cell Receptor (BCR) | 163 | 1.56e-03 | -0.144000 | 1.50e-02 |
| HDMs demethylate histones | 22 | 2.44e-01 | -0.144000 | 4.48e-01 |
| CLEC7A (Dectin-1) signaling | 98 | 1.42e-02 | -0.143000 | 7.26e-02 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 84 | 2.33e-02 | -0.143000 | 1.01e-01 |
| Cytochrome c-mediated apoptotic response | 13 | 3.72e-01 | 0.143000 | 5.75e-01 |
| Mismatch Repair | 15 | 3.38e-01 | -0.143000 | 5.42e-01 |
| Hyaluronan uptake and degradation | 10 | 4.34e-01 | -0.143000 | 6.31e-01 |
| Activation of BH3-only proteins | 30 | 1.76e-01 | -0.143000 | 3.72e-01 |
| APC/C:Cdc20 mediated degradation of Securin | 67 | 4.38e-02 | -0.142000 | 1.52e-01 |
| Regulation of ornithine decarboxylase (ODC) | 50 | 8.19e-02 | -0.142000 | 2.31e-01 |
| Viral Messenger RNA Synthesis | 44 | 1.03e-01 | -0.142000 | 2.62e-01 |
| Aflatoxin activation and detoxification | 15 | 3.42e-01 | -0.142000 | 5.46e-01 |
| Trafficking and processing of endosomal TLR | 13 | 3.78e-01 | 0.141000 | 5.81e-01 |
| Signaling by WNT in cancer | 30 | 1.81e-01 | -0.141000 | 3.79e-01 |
| Smooth Muscle Contraction | 31 | 1.75e-01 | -0.141000 | 3.71e-01 |
| EPH-Ephrin signaling | 80 | 2.97e-02 | -0.141000 | 1.17e-01 |
| FCERI mediated NF-kB activation | 138 | 4.41e-03 | -0.140000 | 3.22e-02 |
| SARS-CoV Infections | 83 | 2.73e-02 | -0.140000 | 1.10e-01 |
| ABC-family proteins mediated transport | 94 | 1.90e-02 | -0.140000 | 8.88e-02 |
| Infection with Mycobacterium tuberculosis | 26 | 2.17e-01 | -0.140000 | 4.15e-01 |
| Platelet degranulation | 104 | 1.37e-02 | -0.140000 | 7.10e-02 |
| Downstream signaling events of B Cell Receptor (BCR) | 80 | 3.06e-02 | -0.140000 | 1.20e-01 |
| FRS-mediated FGFR4 signaling | 12 | 4.02e-01 | 0.140000 | 5.99e-01 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | 28 | 2.01e-01 | -0.139000 | 4.01e-01 |
| RA biosynthesis pathway | 13 | 3.87e-01 | -0.139000 | 5.85e-01 |
| Response to elevated platelet cytosolic Ca2+ | 108 | 1.29e-02 | -0.138000 | 6.75e-02 |
| TP53 Regulates Metabolic Genes | 86 | 2.66e-02 | -0.138000 | 1.09e-01 |
| Transcription of E2F targets under negative control by DREAM complex | 19 | 2.97e-01 | -0.138000 | 5.01e-01 |
| Insulin processing | 20 | 2.85e-01 | 0.138000 | 4.86e-01 |
| Caspase activation via Death Receptors in the presence of ligand | 16 | 3.40e-01 | 0.138000 | 5.44e-01 |
| Synthesis of substrates in N-glycan biosythesis | 58 | 7.06e-02 | -0.137000 | 2.06e-01 |
| Signaling by TGFB family members | 91 | 2.37e-02 | -0.137000 | 1.02e-01 |
| Cellular response to hypoxia | 72 | 4.45e-02 | -0.137000 | 1.54e-01 |
| Thrombin signalling through proteinase activated receptors (PARs) | 27 | 2.19e-01 | -0.137000 | 4.18e-01 |
| CD22 mediated BCR regulation | 59 | 6.92e-02 | -0.137000 | 2.06e-01 |
| Activation of Matrix Metalloproteinases | 24 | 2.48e-01 | -0.136000 | 4.52e-01 |
| Collagen degradation | 29 | 2.04e-01 | -0.136000 | 4.04e-01 |
| Glucose metabolism | 83 | 3.20e-02 | -0.136000 | 1.22e-01 |
| Metabolism of proteins | 1722 | 5.30e-21 | -0.136000 | 2.41e-19 |
| APC/C:Cdc20 mediated degradation of Cyclin B | 24 | 2.54e-01 | -0.134000 | 4.54e-01 |
| Degradation of GLI1 by the proteasome | 58 | 7.68e-02 | -0.134000 | 2.21e-01 |
| G alpha (s) signalling events | 145 | 5.23e-03 | 0.134000 | 3.63e-02 |
| Synthesis of PC | 23 | 2.65e-01 | 0.134000 | 4.69e-01 |
| Signaling by NOTCH2 | 30 | 2.05e-01 | -0.134000 | 4.04e-01 |
| MTOR signalling | 39 | 1.49e-01 | -0.134000 | 3.33e-01 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 14 | 3.87e-01 | 0.133000 | 5.85e-01 |
| Apoptosis induced DNA fragmentation | 10 | 4.65e-01 | 0.133000 | 6.59e-01 |
| Interleukin-1 signaling | 98 | 2.31e-02 | -0.133000 | 1.01e-01 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 10 | 4.67e-01 | -0.133000 | 6.60e-01 |
| Defective EXT2 causes exostoses 2 | 10 | 4.67e-01 | -0.133000 | 6.60e-01 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 11 | 4.47e-01 | -0.132000 | 6.44e-01 |
| Disorders of transmembrane transporters | 147 | 5.67e-03 | -0.132000 | 3.89e-02 |
| Global Genome Nucleotide Excision Repair (GG-NER) | 84 | 3.66e-02 | -0.132000 | 1.35e-01 |
| Interleukin-17 signaling | 68 | 6.01e-02 | -0.132000 | 1.86e-01 |
| Signaling by NTRK1 (TRKA) | 102 | 2.14e-02 | -0.132000 | 9.55e-02 |
| Negative regulation of FGFR1 signaling | 24 | 2.65e-01 | -0.132000 | 4.69e-01 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 88 | 3.29e-02 | -0.132000 | 1.25e-01 |
| Activation of NMDA receptors and postsynaptic events | 60 | 7.82e-02 | -0.131000 | 2.24e-01 |
| Fertilization | 13 | 4.12e-01 | -0.131000 | 6.08e-01 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 65 | 6.71e-02 | -0.131000 | 2.02e-01 |
| Mitotic Spindle Checkpoint | 108 | 1.84e-02 | 0.131000 | 8.72e-02 |
| RHO GTPases activate IQGAPs | 11 | 4.51e-01 | 0.131000 | 6.46e-01 |
| Signaling by Non-Receptor Tyrosine Kinases | 48 | 1.16e-01 | -0.131000 | 2.83e-01 |
| Signaling by PTK6 | 48 | 1.16e-01 | -0.131000 | 2.83e-01 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) | 36 | 1.74e-01 | -0.131000 | 3.71e-01 |
| DARPP-32 events | 22 | 2.88e-01 | -0.131000 | 4.89e-01 |
| Signaling by FGFR4 in disease | 11 | 4.53e-01 | 0.131000 | 6.46e-01 |
| Post NMDA receptor activation events | 50 | 1.11e-01 | -0.130000 | 2.76e-01 |
| Formation of Fibrin Clot (Clotting Cascade) | 26 | 2.51e-01 | -0.130000 | 4.52e-01 |
| Caspase activation via extrinsic apoptotic signalling pathway | 25 | 2.62e-01 | 0.130000 | 4.66e-01 |
| TICAM1-dependent activation of IRF3/IRF7 | 12 | 4.38e-01 | -0.129000 | 6.35e-01 |
| Lagging Strand Synthesis | 20 | 3.17e-01 | -0.129000 | 5.20e-01 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 92 | 3.22e-02 | -0.129000 | 1.22e-01 |
| Toll Like Receptor 2 (TLR2) Cascade | 92 | 3.22e-02 | -0.129000 | 1.22e-01 |
| Toll Like Receptor TLR1:TLR2 Cascade | 92 | 3.22e-02 | -0.129000 | 1.22e-01 |
| Toll Like Receptor TLR6:TLR2 Cascade | 92 | 3.22e-02 | -0.129000 | 1.22e-01 |
| Neutrophil degranulation | 459 | 2.19e-06 | -0.129000 | 4.45e-05 |
| Hedgehog ligand biogenesis | 59 | 8.82e-02 | -0.128000 | 2.40e-01 |
| Cargo recognition for clathrin-mediated endocytosis | 90 | 3.54e-02 | -0.128000 | 1.32e-01 |
| SUMOylation of intracellular receptors | 27 | 2.49e-01 | -0.128000 | 4.52e-01 |
| MAPK targets/ Nuclear events mediated by MAP kinases | 31 | 2.19e-01 | -0.128000 | 4.19e-01 |
| Negative regulation of MAPK pathway | 42 | 1.55e-01 | -0.127000 | 3.42e-01 |
| p75 NTR receptor-mediated signalling | 88 | 3.97e-02 | -0.127000 | 1.43e-01 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 25 | 2.73e-01 | -0.127000 | 4.75e-01 |
| Cohesin Loading onto Chromatin | 10 | 4.88e-01 | 0.127000 | 6.77e-01 |
| CTLA4 inhibitory signaling | 21 | 3.16e-01 | -0.126000 | 5.19e-01 |
| MAP kinase activation | 63 | 8.28e-02 | -0.126000 | 2.31e-01 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | 20 | 3.28e-01 | -0.126000 | 5.31e-01 |
| Neurodegenerative Diseases | 20 | 3.28e-01 | -0.126000 | 5.31e-01 |
| Metabolism of polyamines | 58 | 9.63e-02 | -0.126000 | 2.52e-01 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | 23 | 2.95e-01 | -0.126000 | 4.98e-01 |
| VEGFR2 mediated vascular permeability | 26 | 2.66e-01 | -0.126000 | 4.69e-01 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | 16 | 3.82e-01 | -0.126000 | 5.83e-01 |
| Signaling by Receptor Tyrosine Kinases | 413 | 1.21e-05 | -0.125000 | 2.16e-04 |
| Interferon gamma signaling | 83 | 4.87e-02 | 0.125000 | 1.63e-01 |
| Transcriptional regulation by RUNX1 | 185 | 3.35e-03 | -0.125000 | 2.65e-02 |
| RHO GTPases activate CIT | 18 | 3.59e-01 | 0.125000 | 5.63e-01 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | 88 | 4.33e-02 | -0.125000 | 1.51e-01 |
| Methylation | 12 | 4.55e-01 | -0.125000 | 6.48e-01 |
| RHO GTPases activate PKNs | 47 | 1.40e-01 | -0.124000 | 3.20e-01 |
| Cell junction organization | 59 | 9.83e-02 | -0.124000 | 2.54e-01 |
| Signaling by NOTCH4 | 79 | 5.59e-02 | -0.124000 | 1.76e-01 |
| Acyl chain remodelling of PS | 14 | 4.22e-01 | -0.124000 | 6.19e-01 |
| Signaling by NTRKs | 117 | 2.08e-02 | -0.124000 | 9.31e-02 |
| Protein folding | 90 | 4.26e-02 | -0.124000 | 1.49e-01 |
| Mitotic Telophase/Cytokinesis | 13 | 4.40e-01 | 0.124000 | 6.37e-01 |
| G beta:gamma signalling through PI3Kgamma | 22 | 3.16e-01 | -0.124000 | 5.19e-01 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 14 | 4.24e-01 | -0.124000 | 6.20e-01 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 17 | 3.80e-01 | 0.123000 | 5.82e-01 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 17 | 3.80e-01 | 0.123000 | 5.82e-01 |
| GRB2 events in ERBB2 signaling | 11 | 4.81e-01 | -0.123000 | 6.71e-01 |
| Negative regulation of the PI3K/AKT network | 87 | 4.82e-02 | -0.123000 | 1.63e-01 |
| Signaling by VEGF | 97 | 3.71e-02 | -0.122000 | 1.36e-01 |
| Dectin-2 family | 19 | 3.56e-01 | 0.122000 | 5.60e-01 |
| Alpha-protein kinase 1 signaling pathway | 11 | 4.83e-01 | -0.122000 | 6.71e-01 |
| Cell surface interactions at the vascular wall | 174 | 5.43e-03 | -0.122000 | 3.75e-02 |
| Integration of energy metabolism | 86 | 5.04e-02 | -0.122000 | 1.67e-01 |
| Transferrin endocytosis and recycling | 26 | 2.83e-01 | -0.122000 | 4.84e-01 |
| Citric acid cycle (TCA cycle) | 22 | 3.24e-01 | -0.121000 | 5.27e-01 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 53 | 1.27e-01 | -0.121000 | 3.00e-01 |
| VxPx cargo-targeting to cilium | 19 | 3.61e-01 | 0.121000 | 5.64e-01 |
| RNA Polymerase I Transcription Termination | 30 | 2.51e-01 | -0.121000 | 4.52e-01 |
| Transcriptional regulation of granulopoiesis | 46 | 1.56e-01 | -0.121000 | 3.44e-01 |
| Ion homeostasis | 41 | 1.82e-01 | -0.120000 | 3.80e-01 |
| Stabilization of p53 | 55 | 1.23e-01 | -0.120000 | 2.93e-01 |
| Platelet Aggregation (Plug Formation) | 28 | 2.73e-01 | -0.120000 | 4.75e-01 |
| MyD88 dependent cascade initiated on endosome | 89 | 5.10e-02 | -0.120000 | 1.67e-01 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | 89 | 5.10e-02 | -0.120000 | 1.67e-01 |
| Activation of the AP-1 family of transcription factors | 10 | 5.13e-01 | -0.119000 | 6.89e-01 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 20 | 3.56e-01 | -0.119000 | 5.60e-01 |
| Rab regulation of trafficking | 120 | 2.42e-02 | -0.119000 | 1.03e-01 |
| Toll Like Receptor 3 (TLR3) Cascade | 92 | 4.84e-02 | -0.119000 | 1.63e-01 |
| Platelet activation, signaling and aggregation | 219 | 2.41e-03 | -0.119000 | 2.07e-02 |
| Sialic acid metabolism | 28 | 2.77e-01 | -0.119000 | 4.78e-01 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 14 | 4.42e-01 | -0.119000 | 6.38e-01 |
| Bile acid and bile salt metabolism | 28 | 2.77e-01 | 0.119000 | 4.78e-01 |
| Branched-chain amino acid catabolism | 21 | 3.47e-01 | 0.118000 | 5.51e-01 |
| Platelet calcium homeostasis | 22 | 3.37e-01 | -0.118000 | 5.42e-01 |
| ER Quality Control Compartment (ERQC) | 21 | 3.50e-01 | -0.118000 | 5.53e-01 |
| Anti-inflammatory response favouring Leishmania parasite infection | 170 | 8.07e-03 | -0.118000 | 4.94e-02 |
| Leishmania parasite growth and survival | 170 | 8.07e-03 | -0.118000 | 4.94e-02 |
| HIV Life Cycle | 144 | 1.47e-02 | -0.118000 | 7.44e-02 |
| TNFR1-induced proapoptotic signaling | 12 | 4.80e-01 | -0.118000 | 6.71e-01 |
| DNA strand elongation | 32 | 2.50e-01 | -0.118000 | 4.52e-01 |
| HuR (ELAVL1) binds and stabilizes mRNA | 10 | 5.20e-01 | 0.117000 | 6.94e-01 |
| Regulation of Apoptosis | 52 | 1.43e-01 | -0.117000 | 3.26e-01 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 12 | 4.83e-01 | -0.117000 | 6.71e-01 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 43 | 1.85e-01 | -0.117000 | 3.85e-01 |
| FLT3 Signaling | 245 | 1.68e-03 | -0.117000 | 1.59e-02 |
| Transcription of the HIV genome | 67 | 9.91e-02 | -0.117000 | 2.54e-01 |
| RAF/MAP kinase cascade | 231 | 2.32e-03 | -0.116000 | 2.02e-02 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | 14 | 4.52e-01 | 0.116000 | 6.46e-01 |
| Regulation of beta-cell development | 20 | 3.69e-01 | -0.116000 | 5.73e-01 |
| G beta:gamma signalling through PLC beta | 17 | 4.08e-01 | -0.116000 | 6.04e-01 |
| Post-chaperonin tubulin folding pathway | 19 | 3.82e-01 | -0.116000 | 5.83e-01 |
| tRNA modification in the nucleus and cytosol | 43 | 1.89e-01 | -0.116000 | 3.90e-01 |
| Class I peroxisomal membrane protein import | 20 | 3.72e-01 | -0.115000 | 5.75e-01 |
| CDK-mediated phosphorylation and removal of Cdc6 | 72 | 9.05e-02 | -0.115000 | 2.43e-01 |
| Oncogene Induced Senescence | 33 | 2.51e-01 | -0.115000 | 4.52e-01 |
| Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 12 | 4.91e-01 | -0.115000 | 6.79e-01 |
| Diseases of hemostasis | 12 | 4.91e-01 | -0.115000 | 6.79e-01 |
| Role of LAT2/NTAL/LAB on calcium mobilization | 74 | 8.83e-02 | -0.115000 | 2.40e-01 |
| Cell death signalling via NRAGE, NRIF and NADE | 69 | 9.98e-02 | -0.115000 | 2.55e-01 |
| HCMV Early Events | 74 | 8.86e-02 | -0.114000 | 2.40e-01 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 73 | 9.10e-02 | -0.114000 | 2.43e-01 |
| Striated Muscle Contraction | 25 | 3.22e-01 | -0.114000 | 5.25e-01 |
| Fc epsilon receptor (FCERI) signaling | 191 | 6.55e-03 | -0.114000 | 4.21e-02 |
| Listeria monocytogenes entry into host cells | 17 | 4.15e-01 | -0.114000 | 6.12e-01 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | 34 | 2.50e-01 | -0.114000 | 4.52e-01 |
| Extracellular matrix organization | 220 | 3.66e-03 | -0.114000 | 2.82e-02 |
| Growth hormone receptor signaling | 20 | 3.80e-01 | 0.113000 | 5.82e-01 |
| Constitutive Signaling by Overexpressed ERBB2 | 11 | 5.15e-01 | 0.113000 | 6.89e-01 |
| Regulation of pyruvate dehydrogenase (PDH) complex | 15 | 4.49e-01 | 0.113000 | 6.45e-01 |
| Class B/2 (Secretin family receptors) | 57 | 1.41e-01 | -0.113000 | 3.23e-01 |
| Scavenging of heme from plasma | 71 | 1.01e-01 | -0.113000 | 2.58e-01 |
| Sphingolipid de novo biosynthesis | 41 | 2.14e-01 | 0.112000 | 4.12e-01 |
| Extra-nuclear estrogen signaling | 66 | 1.16e-01 | -0.112000 | 2.83e-01 |
| Late Phase of HIV Life Cycle | 131 | 2.70e-02 | -0.112000 | 1.10e-01 |
| NRAGE signals death through JNK | 52 | 1.63e-01 | -0.112000 | 3.56e-01 |
| Regulation of RAS by GAPs | 67 | 1.14e-01 | -0.112000 | 2.81e-01 |
| Thromboxane signalling through TP receptor | 20 | 3.87e-01 | -0.112000 | 5.85e-01 |
| Glutathione synthesis and recycling | 10 | 5.41e-01 | -0.112000 | 7.10e-01 |
| Opioid Signalling | 75 | 9.47e-02 | -0.112000 | 2.50e-01 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | 22 | 3.69e-01 | -0.111000 | 5.73e-01 |
| Chaperonin-mediated protein folding | 84 | 8.04e-02 | -0.110000 | 2.28e-01 |
| MAPK1/MAPK3 signaling | 236 | 3.52e-03 | -0.110000 | 2.73e-02 |
| SUMO E3 ligases SUMOylate target proteins | 161 | 1.58e-02 | -0.110000 | 7.83e-02 |
| RHO GTPases Activate Formins | 117 | 3.97e-02 | 0.110000 | 1.43e-01 |
| Activation of G protein gated Potassium channels | 20 | 3.95e-01 | 0.110000 | 5.91e-01 |
| G protein gated Potassium channels | 20 | 3.95e-01 | 0.110000 | 5.91e-01 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 20 | 3.95e-01 | 0.110000 | 5.91e-01 |
| Leishmania infection | 246 | 2.98e-03 | -0.110000 | 2.38e-02 |
| Glycosphingolipid metabolism | 36 | 2.54e-01 | -0.110000 | 4.54e-01 |
| RHO GTPases Activate ROCKs | 18 | 4.20e-01 | 0.110000 | 6.17e-01 |
| VEGFA-VEGFR2 Pathway | 90 | 7.20e-02 | -0.110000 | 2.10e-01 |
| p130Cas linkage to MAPK signaling for integrins | 11 | 5.29e-01 | 0.110000 | 7.02e-01 |
| Transcriptional regulation of white adipocyte differentiation | 77 | 9.64e-02 | -0.110000 | 2.52e-01 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | 12 | 5.11e-01 | 0.110000 | 6.88e-01 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | 59 | 1.46e-01 | -0.109000 | 3.29e-01 |
| Meiotic synapsis | 45 | 2.06e-01 | -0.109000 | 4.05e-01 |
| Glucagon signaling in metabolic regulation | 27 | 3.28e-01 | -0.109000 | 5.31e-01 |
| Signaling by FGFR | 69 | 1.18e-01 | -0.109000 | 2.86e-01 |
| Integrin cell surface interactions | 52 | 1.75e-01 | -0.109000 | 3.71e-01 |
| Signaling by ERBB2 | 44 | 2.12e-01 | -0.109000 | 4.11e-01 |
| EPHA-mediated growth cone collapse | 13 | 4.98e-01 | 0.109000 | 6.84e-01 |
| Tie2 Signaling | 16 | 4.52e-01 | 0.109000 | 6.46e-01 |
| MAP2K and MAPK activation | 34 | 2.74e-01 | -0.108000 | 4.75e-01 |
| G alpha (z) signalling events | 36 | 2.63e-01 | -0.108000 | 4.67e-01 |
| MyD88-independent TLR4 cascade | 96 | 6.84e-02 | -0.108000 | 2.04e-01 |
| TRIF(TICAM1)-mediated TLR4 signaling | 96 | 6.84e-02 | -0.108000 | 2.04e-01 |
| Glucagon-type ligand receptors | 20 | 4.07e-01 | -0.107000 | 6.04e-01 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | 10 | 5.58e-01 | 0.107000 | 7.25e-01 |
| APC-Cdc20 mediated degradation of Nek2A | 26 | 3.45e-01 | -0.107000 | 5.48e-01 |
| NOTCH3 Intracellular Domain Regulates Transcription | 21 | 3.99e-01 | -0.106000 | 5.96e-01 |
| Role of phospholipids in phagocytosis | 88 | 8.50e-02 | -0.106000 | 2.34e-01 |
| Erythropoietin activates RAS | 13 | 5.08e-01 | 0.106000 | 6.87e-01 |
| Mucopolysaccharidoses | 11 | 5.43e-01 | -0.106000 | 7.12e-01 |
| Regulation of HSF1-mediated heat shock response | 79 | 1.04e-01 | -0.106000 | 2.62e-01 |
| FCERI mediated Ca+2 mobilization | 89 | 8.45e-02 | -0.106000 | 2.34e-01 |
| HDR through Homologous Recombination (HRR) | 66 | 1.39e-01 | 0.105000 | 3.19e-01 |
| Plasma lipoprotein assembly | 11 | 5.45e-01 | -0.105000 | 7.14e-01 |
| Unfolded Protein Response (UPR) | 88 | 8.83e-02 | -0.105000 | 2.40e-01 |
| FCERI mediated MAPK activation | 90 | 8.48e-02 | -0.105000 | 2.34e-01 |
| Assembly of the pre-replicative complex | 67 | 1.37e-01 | -0.105000 | 3.16e-01 |
| Cross-presentation of soluble exogenous antigens (endosomes) | 48 | 2.10e-01 | -0.105000 | 4.10e-01 |
| CLEC7A (Dectin-1) induces NFAT activation | 11 | 5.49e-01 | -0.104000 | 7.18e-01 |
| Clathrin-mediated endocytosis | 127 | 4.27e-02 | -0.104000 | 1.49e-01 |
| AMER1 mutants destabilize the destruction complex | 14 | 5.01e-01 | -0.104000 | 6.84e-01 |
| APC truncation mutants have impaired AXIN binding | 14 | 5.01e-01 | -0.104000 | 6.84e-01 |
| AXIN missense mutants destabilize the destruction complex | 14 | 5.01e-01 | -0.104000 | 6.84e-01 |
| AXIN mutants destabilize the destruction complex, activating WNT signaling | 14 | 5.01e-01 | -0.104000 | 6.84e-01 |
| Truncations of AMER1 destabilize the destruction complex | 14 | 5.01e-01 | -0.104000 | 6.84e-01 |
| truncated APC mutants destabilize the destruction complex | 14 | 5.01e-01 | -0.104000 | 6.84e-01 |
| Deadenylation of mRNA | 22 | 4.00e-01 | 0.104000 | 5.96e-01 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 80 | 1.10e-01 | -0.103000 | 2.75e-01 |
| Neddylation | 219 | 8.44e-03 | -0.103000 | 5.03e-02 |
| Ras activation upon Ca2+ influx through NMDA receptor | 16 | 4.76e-01 | -0.103000 | 6.68e-01 |
| NOTCH4 Intracellular Domain Regulates Transcription | 18 | 4.50e-01 | -0.103000 | 6.46e-01 |
| Signaling by FGFR2 in disease | 32 | 3.15e-01 | -0.103000 | 5.19e-01 |
| Synthesis of bile acids and bile salts | 24 | 3.86e-01 | 0.102000 | 5.85e-01 |
| mRNA 3'-end processing | 56 | 1.87e-01 | -0.102000 | 3.86e-01 |
| Intrinsic Pathway of Fibrin Clot Formation | 16 | 4.82e-01 | -0.102000 | 6.71e-01 |
| RUNX3 regulates NOTCH signaling | 14 | 5.11e-01 | -0.101000 | 6.88e-01 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | 11 | 5.61e-01 | -0.101000 | 7.27e-01 |
| Aquaporin-mediated transport | 38 | 2.81e-01 | -0.101000 | 4.81e-01 |
| Vasopressin regulates renal water homeostasis via Aquaporins | 34 | 3.08e-01 | -0.101000 | 5.15e-01 |
| Signaling by ERBB2 ECD mutants | 15 | 4.99e-01 | 0.101000 | 6.84e-01 |
| Glycolysis | 66 | 1.58e-01 | -0.101000 | 3.47e-01 |
| G alpha (q) signalling events | 134 | 4.50e-02 | -0.100000 | 1.54e-01 |
| Processing and activation of SUMO | 10 | 5.83e-01 | 0.100000 | 7.43e-01 |
| p38MAPK events | 13 | 5.32e-01 | -0.100000 | 7.04e-01 |
| RNA Polymerase III Abortive And Retractive Initiation | 41 | 2.68e-01 | -0.100000 | 4.70e-01 |
| RNA Polymerase III Transcription | 41 | 2.68e-01 | -0.100000 | 4.70e-01 |
| Diseases associated with glycosylation precursor biosynthesis | 18 | 4.63e-01 | -0.100000 | 6.57e-01 |
| RAF activation | 32 | 3.30e-01 | 0.099500 | 5.33e-01 |
| Misspliced GSK3beta mutants stabilize beta-catenin | 15 | 5.05e-01 | -0.099500 | 6.84e-01 |
| S33 mutants of beta-catenin aren't phosphorylated | 15 | 5.05e-01 | -0.099500 | 6.84e-01 |
| S37 mutants of beta-catenin aren't phosphorylated | 15 | 5.05e-01 | -0.099500 | 6.84e-01 |
| S45 mutants of beta-catenin aren't phosphorylated | 15 | 5.05e-01 | -0.099500 | 6.84e-01 |
| T41 mutants of beta-catenin aren't phosphorylated | 15 | 5.05e-01 | -0.099500 | 6.84e-01 |
| phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex | 15 | 5.05e-01 | -0.099500 | 6.84e-01 |
| Basigin interactions | 23 | 4.09e-01 | -0.099400 | 6.05e-01 |
| Mitotic Prometaphase | 185 | 1.97e-02 | 0.099400 | 9.08e-02 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 11 | 5.68e-01 | 0.099400 | 7.32e-01 |
| Metabolism of fat-soluble vitamins | 28 | 3.64e-01 | -0.099000 | 5.68e-01 |
| SUMOylation | 167 | 2.73e-02 | -0.099000 | 1.10e-01 |
| Toll Like Receptor 9 (TLR9) Cascade | 93 | 9.91e-02 | -0.099000 | 2.54e-01 |
| Acyl chain remodelling of PC | 19 | 4.56e-01 | -0.098800 | 6.49e-01 |
| Phase 0 - rapid depolarisation | 29 | 3.58e-01 | 0.098500 | 5.63e-01 |
| RUNX3 regulates p14-ARF | 10 | 5.90e-01 | 0.098500 | 7.48e-01 |
| Hemostasis | 547 | 8.17e-05 | -0.098500 | 1.19e-03 |
| Constitutive Signaling by Aberrant PI3K in Cancer | 54 | 2.12e-01 | -0.098300 | 4.10e-01 |
| SUMOylation of ubiquitinylation proteins | 39 | 2.89e-01 | 0.098200 | 4.89e-01 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 15 | 5.10e-01 | -0.098200 | 6.88e-01 |
| Regulation of PTEN stability and activity | 67 | 1.65e-01 | -0.098100 | 3.59e-01 |
| IL-6-type cytokine receptor ligand interactions | 13 | 5.41e-01 | 0.097900 | 7.10e-01 |
| Unwinding of DNA | 12 | 5.57e-01 | -0.097800 | 7.25e-01 |
| CDT1 association with the CDC6:ORC:origin complex | 58 | 1.98e-01 | -0.097700 | 3.98e-01 |
| Phase 4 - resting membrane potential | 10 | 5.93e-01 | 0.097500 | 7.50e-01 |
| Diseases of metabolism | 191 | 2.03e-02 | -0.097300 | 9.25e-02 |
| DAP12 interactions | 39 | 2.93e-01 | -0.097300 | 4.96e-01 |
| O-linked glycosylation | 85 | 1.22e-01 | -0.097100 | 2.92e-01 |
| DNA Replication Pre-Initiation | 83 | 1.26e-01 | -0.097100 | 2.99e-01 |
| Polo-like kinase mediated events | 15 | 5.16e-01 | 0.097000 | 6.89e-01 |
| Regulated proteolysis of p75NTR | 11 | 5.78e-01 | 0.096900 | 7.40e-01 |
| Inwardly rectifying K+ channels | 24 | 4.12e-01 | 0.096800 | 6.08e-01 |
| Mitochondrial tRNA aminoacylation | 21 | 4.43e-01 | -0.096600 | 6.40e-01 |
| Cyclin A:Cdk2-associated events at S phase entry | 85 | 1.24e-01 | -0.096500 | 2.95e-01 |
| Iron uptake and transport | 52 | 2.29e-01 | -0.096400 | 4.31e-01 |
| Mitochondrial Fatty Acid Beta-Oxidation | 36 | 3.18e-01 | -0.096200 | 5.21e-01 |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | 17 | 4.92e-01 | 0.096200 | 6.80e-01 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 36 | 3.19e-01 | -0.096000 | 5.21e-01 |
| Prolactin receptor signaling | 11 | 5.82e-01 | 0.095800 | 7.43e-01 |
| Dual Incision in GG-NER | 41 | 2.89e-01 | -0.095800 | 4.89e-01 |
| PECAM1 interactions | 12 | 5.66e-01 | -0.095800 | 7.30e-01 |
| Amine ligand-binding receptors | 10 | 6.02e-01 | 0.095300 | 7.55e-01 |
| Toll Like Receptor 4 (TLR4) Cascade | 121 | 7.02e-02 | -0.095300 | 2.06e-01 |
| Golgi Cisternae Pericentriolar Stack Reorganization | 14 | 5.37e-01 | 0.095200 | 7.09e-01 |
| Fcgamma receptor (FCGR) dependent phagocytosis | 147 | 4.66e-02 | -0.095100 | 1.58e-01 |
| Transcriptional Regulation by TP53 | 352 | 2.21e-03 | -0.094900 | 1.98e-02 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 72 | 1.67e-01 | -0.094200 | 3.60e-01 |
| ER-Phagosome pathway | 83 | 1.39e-01 | -0.094000 | 3.19e-01 |
| Innate Immune System | 969 | 7.38e-07 | -0.093900 | 1.74e-05 |
| CASP8 activity is inhibited | 11 | 5.90e-01 | 0.093700 | 7.48e-01 |
| Dimerization of procaspase-8 | 11 | 5.90e-01 | 0.093700 | 7.48e-01 |
| Regulation by c-FLIP | 11 | 5.90e-01 | 0.093700 | 7.48e-01 |
| Dissolution of Fibrin Clot | 12 | 5.75e-01 | -0.093600 | 7.38e-01 |
| RNA Polymerase II Pre-transcription Events | 78 | 1.53e-01 | -0.093600 | 3.40e-01 |
| FCGR3A-mediated IL10 synthesis | 99 | 1.08e-01 | -0.093400 | 2.73e-01 |
| Vitamin B5 (pantothenate) metabolism | 17 | 5.07e-01 | 0.093100 | 6.86e-01 |
| Transcriptional regulation by RUNX3 | 90 | 1.27e-01 | -0.093000 | 3.00e-01 |
| G beta:gamma signalling through CDC42 | 17 | 5.09e-01 | 0.092500 | 6.87e-01 |
| Adaptive Immune System | 758 | 1.49e-05 | -0.092400 | 2.61e-04 |
| Generic Transcription Pathway | 1087 | 2.67e-07 | -0.092400 | 6.63e-06 |
| MAPK family signaling cascades | 270 | 9.03e-03 | -0.092300 | 5.29e-02 |
| EPHB-mediated forward signaling | 33 | 3.59e-01 | 0.092300 | 5.63e-01 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 18 | 4.98e-01 | -0.092200 | 6.84e-01 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | 18 | 4.98e-01 | -0.092200 | 6.84e-01 |
| GPVI-mediated activation cascade | 31 | 3.76e-01 | -0.091900 | 5.79e-01 |
| Meiotic recombination | 38 | 3.27e-01 | -0.091900 | 5.31e-01 |
| Circadian Clock | 67 | 1.95e-01 | -0.091600 | 3.94e-01 |
| FCGR3A-mediated phagocytosis | 121 | 8.28e-02 | -0.091300 | 2.31e-01 |
| Leishmania phagocytosis | 121 | 8.28e-02 | -0.091300 | 2.31e-01 |
| Parasite infection | 121 | 8.28e-02 | -0.091300 | 2.31e-01 |
| Regulation of actin dynamics for phagocytic cup formation | 123 | 8.05e-02 | -0.091200 | 2.28e-01 |
| Signaling by Interleukins | 388 | 2.10e-03 | -0.090900 | 1.92e-02 |
| Asparagine N-linked glycosylation | 269 | 1.04e-02 | -0.090800 | 5.78e-02 |
| p53-Dependent G1 DNA Damage Response | 64 | 2.11e-01 | -0.090400 | 4.10e-01 |
| p53-Dependent G1/S DNA damage checkpoint | 64 | 2.11e-01 | -0.090400 | 4.10e-01 |
| Activation of gene expression by SREBF (SREBP) | 42 | 3.13e-01 | -0.089900 | 5.18e-01 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 32 | 3.79e-01 | -0.089900 | 5.82e-01 |
| Signaling by FGFR4 | 31 | 3.86e-01 | -0.089900 | 5.85e-01 |
| Signaling by NTRK2 (TRKB) | 20 | 4.88e-01 | 0.089500 | 6.77e-01 |
| Cyclin E associated events during G1/S transition | 83 | 1.60e-01 | -0.089200 | 3.51e-01 |
| Phospholipid metabolism | 184 | 3.72e-02 | -0.089100 | 1.36e-01 |
| Elastic fibre formation | 32 | 3.85e-01 | -0.088600 | 5.85e-01 |
| BBSome-mediated cargo-targeting to cilium | 22 | 4.73e-01 | -0.088400 | 6.64e-01 |
| G2/M DNA damage checkpoint | 67 | 2.12e-01 | 0.088100 | 4.11e-01 |
| C-type lectin receptors (CLRs) | 130 | 8.50e-02 | -0.087500 | 2.34e-01 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | 40 | 3.39e-01 | -0.087400 | 5.44e-01 |
| Inflammasomes | 20 | 4.99e-01 | 0.087300 | 6.84e-01 |
| HIV Transcription Initiation | 45 | 3.12e-01 | -0.087100 | 5.17e-01 |
| RNA Polymerase II HIV Promoter Escape | 45 | 3.12e-01 | -0.087100 | 5.17e-01 |
| RNA Polymerase II Promoter Escape | 45 | 3.12e-01 | -0.087100 | 5.17e-01 |
| RNA Polymerase II Transcription Initiation | 45 | 3.12e-01 | -0.087100 | 5.17e-01 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | 45 | 3.12e-01 | -0.087100 | 5.17e-01 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 45 | 3.12e-01 | -0.087100 | 5.17e-01 |
| SLC transporter disorders | 76 | 1.90e-01 | -0.087000 | 3.90e-01 |
| STING mediated induction of host immune responses | 15 | 5.60e-01 | -0.086800 | 7.27e-01 |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | 17 | 5.36e-01 | -0.086800 | 7.08e-01 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | 73 | 2.00e-01 | -0.086700 | 3.99e-01 |
| Signaling by Retinoic Acid | 32 | 3.96e-01 | -0.086700 | 5.93e-01 |
| Neuronal System | 262 | 1.58e-02 | -0.086600 | 7.82e-02 |
| TP53 Regulates Transcription of Death Receptors and Ligands | 12 | 6.04e-01 | -0.086500 | 7.56e-01 |
| Diseases of signal transduction by growth factor receptors and second messengers | 343 | 6.05e-03 | -0.086200 | 4.05e-02 |
| Interleukin-1 family signaling | 125 | 9.64e-02 | -0.086100 | 2.52e-01 |
| Recycling pathway of L1 | 26 | 4.48e-01 | -0.085900 | 6.45e-01 |
| PI Metabolism | 79 | 1.87e-01 | -0.085900 | 3.86e-01 |
| Regulation of insulin secretion | 60 | 2.50e-01 | -0.085800 | 4.52e-01 |
| SCF(Skp2)-mediated degradation of p27/p21 | 60 | 2.52e-01 | -0.085500 | 4.52e-01 |
| Regulation of TNFR1 signaling | 32 | 4.03e-01 | -0.085400 | 6.00e-01 |
| Acyl chain remodelling of PE | 20 | 5.10e-01 | -0.085100 | 6.88e-01 |
| PI-3K cascade:FGFR4 | 10 | 6.41e-01 | 0.085100 | 7.87e-01 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 73 | 2.09e-01 | -0.085000 | 4.10e-01 |
| Transport of the SLBP independent Mature mRNA | 35 | 3.84e-01 | 0.085000 | 5.85e-01 |
| G1/S DNA Damage Checkpoints | 66 | 2.33e-01 | -0.084800 | 4.36e-01 |
| Molecules associated with elastic fibres | 22 | 4.91e-01 | -0.084800 | 6.79e-01 |
| Miscellaneous transport and binding events | 20 | 5.12e-01 | -0.084700 | 6.88e-01 |
| Neurotransmitter receptors and postsynaptic signal transmission | 127 | 9.92e-02 | -0.084700 | 2.54e-01 |
| RHO GTPases Activate WASPs and WAVEs | 35 | 3.86e-01 | -0.084700 | 5.85e-01 |
| GRB2 events in EGFR signaling | 11 | 6.28e-01 | -0.084400 | 7.76e-01 |
| Transport of Ribonucleoproteins into the Host Nucleus | 32 | 4.09e-01 | 0.084400 | 6.05e-01 |
| Regulation of TP53 Activity | 153 | 7.20e-02 | -0.084300 | 2.10e-01 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 38 | 3.69e-01 | -0.084200 | 5.73e-01 |
| Regulation of lipid metabolism by PPARalpha | 106 | 1.34e-01 | -0.084200 | 3.11e-01 |
| RNA Polymerase II Transcription | 1206 | 8.54e-07 | -0.084100 | 1.98e-05 |
| Glycerophospholipid biosynthesis | 106 | 1.35e-01 | -0.083900 | 3.13e-01 |
| Regulation of APC/C activators between G1/S and early anaphase | 80 | 1.96e-01 | -0.083700 | 3.95e-01 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 16 | 5.64e-01 | -0.083400 | 7.28e-01 |
| Cellular hexose transport | 15 | 5.76e-01 | -0.083300 | 7.40e-01 |
| Diseases of DNA repair | 10 | 6.48e-01 | -0.083300 | 7.90e-01 |
| Gene expression (Transcription) | 1337 | 4.30e-07 | -0.082300 | 1.05e-05 |
| Signal Transduction | 1899 | 3.13e-09 | -0.082100 | 8.90e-08 |
| Diseases of glycosylation | 111 | 1.36e-01 | -0.082000 | 3.13e-01 |
| MET promotes cell motility | 26 | 4.71e-01 | 0.081600 | 6.64e-01 |
| Synthesis of PIPs at the plasma membrane | 52 | 3.10e-01 | -0.081400 | 5.17e-01 |
| The canonical retinoid cycle in rods (twilight vision) | 10 | 6.56e-01 | -0.081300 | 7.94e-01 |
| RHO GTPases activate PAKs | 20 | 5.29e-01 | 0.081300 | 7.02e-01 |
| Transport of the SLBP Dependant Mature mRNA | 36 | 3.99e-01 | 0.081200 | 5.96e-01 |
| Constitutive Signaling by EGFRvIII | 14 | 6.01e-01 | 0.080700 | 7.55e-01 |
| Signaling by EGFRvIII in Cancer | 14 | 6.01e-01 | 0.080700 | 7.55e-01 |
| PPARA activates gene expression | 104 | 1.55e-01 | -0.080600 | 3.43e-01 |
| Cell-cell junction organization | 38 | 3.91e-01 | -0.080400 | 5.88e-01 |
| Transcriptional Regulation by E2F6 | 34 | 4.18e-01 | 0.080300 | 6.14e-01 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | 75 | 2.29e-01 | -0.080300 | 4.31e-01 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | 49 | 3.31e-01 | 0.080200 | 5.34e-01 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 76 | 2.29e-01 | -0.079800 | 4.31e-01 |
| Orc1 removal from chromatin | 70 | 2.52e-01 | -0.079200 | 4.52e-01 |
| ZBP1(DAI) mediated induction of type I IFNs | 20 | 5.41e-01 | -0.079000 | 7.10e-01 |
| Phase I - Functionalization of compounds | 64 | 2.79e-01 | -0.078200 | 4.79e-01 |
| KSRP (KHSRP) binds and destabilizes mRNA | 17 | 5.79e-01 | -0.077800 | 7.40e-01 |
| Unblocking of NMDA receptors, glutamate binding and activation | 13 | 6.27e-01 | -0.077700 | 7.76e-01 |
| Transport of vitamins, nucleosides, and related molecules | 33 | 4.40e-01 | -0.077700 | 6.37e-01 |
| Binding and Uptake of Ligands by Scavenger Receptors | 92 | 2.02e-01 | -0.077000 | 4.01e-01 |
| Signaling by high-kinase activity BRAF mutants | 31 | 4.58e-01 | -0.077000 | 6.51e-01 |
| FCGR activation | 76 | 2.47e-01 | -0.076800 | 4.51e-01 |
| Metabolic disorders of biological oxidation enzymes | 24 | 5.16e-01 | -0.076600 | 6.89e-01 |
| MAPK6/MAPK4 signaling | 83 | 2.31e-01 | -0.076000 | 4.33e-01 |
| RORA activates gene expression | 18 | 5.77e-01 | -0.076000 | 7.40e-01 |
| Potential therapeutics for SARS | 36 | 4.32e-01 | -0.075700 | 6.30e-01 |
| Synthesis of IP2, IP, and Ins in the cytosol | 13 | 6.39e-01 | 0.075200 | 7.85e-01 |
| Arachidonic acid metabolism | 44 | 3.90e-01 | -0.074900 | 5.87e-01 |
| Activation of ATR in response to replication stress | 36 | 4.37e-01 | 0.074900 | 6.34e-01 |
| Transport of small molecules | 563 | 2.61e-03 | -0.074200 | 2.18e-02 |
| Organelle biogenesis and maintenance | 270 | 3.60e-02 | -0.074200 | 1.33e-01 |
| Peptide hormone metabolism | 49 | 3.73e-01 | 0.073600 | 5.76e-01 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | 38 | 4.33e-01 | -0.073500 | 6.30e-01 |
| Signaling by RAS mutants | 38 | 4.33e-01 | -0.073500 | 6.30e-01 |
| Signaling by moderate kinase activity BRAF mutants | 38 | 4.33e-01 | -0.073500 | 6.30e-01 |
| Signaling downstream of RAS mutants | 38 | 4.33e-01 | -0.073500 | 6.30e-01 |
| Laminin interactions | 21 | 5.60e-01 | -0.073500 | 7.27e-01 |
| Synthesis of DNA | 119 | 1.67e-01 | -0.073300 | 3.60e-01 |
| Regulation of TP53 Activity through Phosphorylation | 89 | 2.34e-01 | 0.072900 | 4.37e-01 |
| Signaling by Insulin receptor | 59 | 3.43e-01 | -0.071400 | 5.46e-01 |
| Antigen processing-Cross presentation | 98 | 2.23e-01 | -0.071200 | 4.25e-01 |
| Switching of origins to a post-replicative state | 90 | 2.46e-01 | -0.070700 | 4.51e-01 |
| Leading Strand Synthesis | 14 | 6.48e-01 | -0.070500 | 7.90e-01 |
| Polymerase switching | 14 | 6.48e-01 | -0.070500 | 7.90e-01 |
| Semaphorin interactions | 57 | 3.59e-01 | -0.070200 | 5.63e-01 |
| VEGFR2 mediated cell proliferation | 18 | 6.06e-01 | -0.070200 | 7.57e-01 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | 12 | 6.77e-01 | 0.069500 | 8.03e-01 |
| MASTL Facilitates Mitotic Progression | 10 | 7.05e-01 | 0.069300 | 8.24e-01 |
| PKMTs methylate histone lysines | 45 | 4.22e-01 | -0.069200 | 6.19e-01 |
| CD209 (DC-SIGN) signaling | 20 | 5.93e-01 | -0.069000 | 7.50e-01 |
| Immune System | 1897 | 6.35e-07 | -0.069000 | 1.52e-05 |
| Non-integrin membrane-ECM interactions | 37 | 4.68e-01 | -0.068900 | 6.61e-01 |
| SUMOylation of chromatin organization proteins | 57 | 3.70e-01 | -0.068600 | 5.74e-01 |
| Energy dependent regulation of mTOR by LKB1-AMPK | 28 | 5.31e-01 | -0.068400 | 7.03e-01 |
| G-protein beta:gamma signalling | 29 | 5.24e-01 | -0.068400 | 6.99e-01 |
| Post-translational protein modification | 1197 | 7.19e-05 | -0.068100 | 1.07e-03 |
| Syndecan interactions | 19 | 6.09e-01 | -0.067800 | 7.60e-01 |
| CD28 dependent Vav1 pathway | 12 | 6.86e-01 | -0.067500 | 8.11e-01 |
| trans-Golgi Network Vesicle Budding | 69 | 3.33e-01 | -0.067300 | 5.37e-01 |
| Diseases associated with N-glycosylation of proteins | 17 | 6.32e-01 | -0.067100 | 7.79e-01 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 13 | 6.75e-01 | -0.067100 | 8.02e-01 |
| Mitotic Prophase | 98 | 2.52e-01 | -0.066900 | 4.52e-01 |
| Cytosolic sulfonation of small molecules | 19 | 6.16e-01 | -0.066600 | 7.67e-01 |
| MHC class II antigen presentation | 101 | 2.51e-01 | -0.066100 | 4.52e-01 |
| Death Receptor Signalling | 131 | 1.92e-01 | -0.066100 | 3.92e-01 |
| Prostacyclin signalling through prostacyclin receptor | 16 | 6.47e-01 | -0.066100 | 7.90e-01 |
| Classical antibody-mediated complement activation | 69 | 3.44e-01 | -0.065900 | 5.47e-01 |
| Deposition of new CENPA-containing nucleosomes at the centromere | 40 | 4.72e-01 | -0.065700 | 6.64e-01 |
| Nucleosome assembly | 40 | 4.72e-01 | -0.065700 | 6.64e-01 |
| Cell Cycle Checkpoints | 259 | 6.87e-02 | 0.065700 | 2.05e-01 |
| Nuclear Envelope (NE) Reassembly | 69 | 3.50e-01 | -0.065000 | 5.53e-01 |
| Signaling by ERBB2 TMD/JMD mutants | 17 | 6.43e-01 | -0.065000 | 7.88e-01 |
| Creation of C4 and C2 activators | 71 | 3.45e-01 | -0.064800 | 5.48e-01 |
| Fatty acyl-CoA biosynthesis | 34 | 5.14e-01 | -0.064700 | 6.89e-01 |
| Toll-like Receptor Cascades | 143 | 1.87e-01 | -0.063900 | 3.86e-01 |
| Degradation of the extracellular matrix | 81 | 3.23e-01 | -0.063500 | 5.26e-01 |
| Regulation of IFNA signaling | 12 | 7.05e-01 | 0.063200 | 8.24e-01 |
| Platelet homeostasis | 70 | 3.61e-01 | -0.063100 | 5.64e-01 |
| Formation of the cornified envelope | 21 | 6.17e-01 | -0.063100 | 7.68e-01 |
| TNF signaling | 42 | 4.82e-01 | -0.062700 | 6.71e-01 |
| Endogenous sterols | 16 | 6.68e-01 | -0.061900 | 7.99e-01 |
| DNA Repair | 289 | 7.06e-02 | -0.061800 | 2.06e-01 |
| G1/S Transition | 130 | 2.24e-01 | -0.061700 | 4.25e-01 |
| NEP/NS2 Interacts with the Cellular Export Machinery | 32 | 5.49e-01 | 0.061200 | 7.18e-01 |
| Zinc transporters | 14 | 6.93e-01 | -0.061000 | 8.15e-01 |
| Transcriptional activation of mitochondrial biogenesis | 51 | 4.51e-01 | -0.061000 | 6.46e-01 |
| TNFs bind their physiological receptors | 25 | 5.98e-01 | -0.060900 | 7.53e-01 |
| HDR through MMEJ (alt-NHEJ) | 10 | 7.39e-01 | 0.060900 | 8.48e-01 |
| RIP-mediated NFkB activation via ZBP1 | 17 | 6.64e-01 | -0.060800 | 7.99e-01 |
| Plasma lipoprotein remodeling | 19 | 6.47e-01 | 0.060800 | 7.90e-01 |
| Fatty acid metabolism | 153 | 1.95e-01 | -0.060700 | 3.94e-01 |
| Vesicle-mediated transport | 649 | 8.34e-03 | -0.060700 | 5.03e-02 |
| Apoptotic factor-mediated response | 18 | 6.57e-01 | 0.060400 | 7.94e-01 |
| Deadenylation-dependent mRNA decay | 53 | 4.48e-01 | -0.060300 | 6.44e-01 |
| Metabolism of porphyrins | 22 | 6.25e-01 | -0.060300 | 7.73e-01 |
| Interleukin-35 Signalling | 12 | 7.18e-01 | 0.060200 | 8.34e-01 |
| Frs2-mediated activation | 11 | 7.30e-01 | -0.060100 | 8.41e-01 |
| Interleukin-4 and Interleukin-13 signaling | 94 | 3.21e-01 | -0.059300 | 5.23e-01 |
| Transmission across Chemical Synapses | 173 | 1.81e-01 | -0.059000 | 3.79e-01 |
| PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | 13 | 7.13e-01 | 0.059000 | 8.29e-01 |
| Signaling by RAF1 mutants | 34 | 5.53e-01 | -0.058800 | 7.21e-01 |
| Adrenaline,noradrenaline inhibits insulin secretion | 24 | 6.19e-01 | -0.058600 | 7.70e-01 |
| Transport to the Golgi and subsequent modification | 155 | 2.09e-01 | -0.058500 | 4.10e-01 |
| Transport of Mature mRNA Derived from an Intronless Transcript | 42 | 5.14e-01 | 0.058200 | 6.89e-01 |
| Membrane Trafficking | 559 | 1.92e-02 | -0.057900 | 8.92e-02 |
| Signaling by KIT in disease | 20 | 6.54e-01 | 0.057900 | 7.92e-01 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | 20 | 6.54e-01 | 0.057900 | 7.92e-01 |
| Regulation of TLR by endogenous ligand | 11 | 7.40e-01 | 0.057700 | 8.49e-01 |
| DAP12 signaling | 28 | 6.00e-01 | -0.057300 | 7.54e-01 |
| SUMOylation of RNA binding proteins | 47 | 4.97e-01 | -0.057300 | 6.84e-01 |
| G alpha (i) signalling events | 246 | 1.27e-01 | -0.056400 | 3.00e-01 |
| Interleukin-6 family signaling | 19 | 6.71e-01 | 0.056400 | 8.00e-01 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 17 | 6.88e-01 | -0.056200 | 8.13e-01 |
| Visual phototransduction | 60 | 4.53e-01 | -0.056100 | 6.46e-01 |
| Metabolism of non-coding RNA | 53 | 4.83e-01 | -0.055700 | 6.71e-01 |
| snRNP Assembly | 53 | 4.83e-01 | -0.055700 | 6.71e-01 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | 43 | 5.28e-01 | 0.055700 | 7.01e-01 |
| S Phase | 161 | 2.24e-01 | -0.055600 | 4.25e-01 |
| Integrin signaling | 22 | 6.53e-01 | -0.055400 | 7.92e-01 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | 31 | 5.95e-01 | 0.055200 | 7.50e-01 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | 31 | 5.95e-01 | 0.055200 | 7.50e-01 |
| G alpha (12/13) signalling events | 68 | 4.32e-01 | -0.055100 | 6.30e-01 |
| PI3K Cascade | 30 | 6.04e-01 | -0.054700 | 7.56e-01 |
| Diseases associated with O-glycosylation of proteins | 50 | 5.04e-01 | -0.054700 | 6.84e-01 |
| Antigen processing: Ubiquitination & Proteasome degradation | 288 | 1.11e-01 | -0.054600 | 2.76e-01 |
| Apoptotic execution phase | 45 | 5.34e-01 | 0.053600 | 7.06e-01 |
| APC/C-mediated degradation of cell cycle proteins | 87 | 3.89e-01 | -0.053500 | 5.86e-01 |
| Regulation of mitotic cell cycle | 87 | 3.89e-01 | -0.053500 | 5.86e-01 |
| Interleukin-12 signaling | 44 | 5.40e-01 | -0.053400 | 7.10e-01 |
| Receptor-type tyrosine-protein phosphatases | 12 | 7.50e-01 | 0.053100 | 8.58e-01 |
| Interleukin receptor SHC signaling | 23 | 6.60e-01 | -0.052900 | 7.97e-01 |
| DNA Replication | 126 | 3.05e-01 | -0.052900 | 5.13e-01 |
| Depolymerisation of the Nuclear Lamina | 15 | 7.24e-01 | 0.052700 | 8.39e-01 |
| NCAM1 interactions | 23 | 6.63e-01 | -0.052400 | 7.98e-01 |
| MET activates PTK2 signaling | 15 | 7.30e-01 | 0.051400 | 8.41e-01 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 36 | 5.94e-01 | -0.051400 | 7.50e-01 |
| Antimicrobial peptides | 34 | 6.04e-01 | -0.051300 | 7.56e-01 |
| Downstream signal transduction | 27 | 6.45e-01 | 0.051300 | 7.90e-01 |
| RUNX2 regulates osteoblast differentiation | 19 | 7.00e-01 | -0.051100 | 8.21e-01 |
| Nucleotide-like (purinergic) receptors | 13 | 7.54e-01 | -0.050300 | 8.61e-01 |
| Metabolism of lipids | 623 | 3.33e-02 | -0.049900 | 1.26e-01 |
| Separation of Sister Chromatids | 168 | 2.69e-01 | 0.049400 | 4.71e-01 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | 72 | 4.70e-01 | -0.049300 | 6.62e-01 |
| Class A/1 (Rhodopsin-like receptors) | 170 | 2.72e-01 | -0.048800 | 4.75e-01 |
| Acyl chain remodelling of PI | 10 | 7.89e-01 | -0.048800 | 8.87e-01 |
| Nucleobase catabolism | 28 | 6.57e-01 | -0.048500 | 7.94e-01 |
| Signaling by ERBB4 | 44 | 5.79e-01 | -0.048400 | 7.40e-01 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | 179 | 2.76e-01 | -0.047200 | 4.78e-01 |
| Intrinsic Pathway for Apoptosis | 53 | 5.55e-01 | -0.046900 | 7.23e-01 |
| Triglyceride metabolism | 25 | 6.90e-01 | 0.046000 | 8.14e-01 |
| Nuclear Pore Complex (NPC) Disassembly | 36 | 6.33e-01 | 0.045900 | 7.80e-01 |
| Ovarian tumor domain proteases | 37 | 6.29e-01 | 0.045900 | 7.76e-01 |
| Biological oxidations | 137 | 3.59e-01 | -0.045300 | 5.63e-01 |
| Reproduction | 81 | 4.81e-01 | -0.045300 | 6.71e-01 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 51 | 5.77e-01 | 0.045100 | 7.40e-01 |
| Defects in cobalamin (B12) metabolism | 13 | 7.78e-01 | 0.045100 | 8.80e-01 |
| Nicotinate metabolism | 26 | 6.93e-01 | 0.044800 | 8.15e-01 |
| RET signaling | 32 | 6.61e-01 | -0.044800 | 7.97e-01 |
| Cargo concentration in the ER | 30 | 6.71e-01 | 0.044700 | 8.00e-01 |
| TICAM1, RIP1-mediated IKK complex recruitment | 19 | 7.36e-01 | 0.044700 | 8.46e-01 |
| GPCR ligand binding | 237 | 2.37e-01 | -0.044600 | 4.39e-01 |
| Netrin-1 signaling | 40 | 6.30e-01 | -0.044000 | 7.77e-01 |
| GABA receptor activation | 36 | 6.48e-01 | 0.044000 | 7.90e-01 |
| NOD1/2 Signaling Pathway | 32 | 6.67e-01 | 0.044000 | 7.99e-01 |
| tRNA Aminoacylation | 42 | 6.22e-01 | 0.044000 | 7.72e-01 |
| Surfactant metabolism | 22 | 7.22e-01 | -0.043700 | 8.39e-01 |
| Signaling by PDGF | 44 | 6.23e-01 | -0.042800 | 7.72e-01 |
| Transcriptional regulation by RUNX2 | 102 | 4.55e-01 | -0.042800 | 6.48e-01 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 25 | 7.13e-01 | 0.042500 | 8.29e-01 |
| Signaling by BMP | 21 | 7.36e-01 | 0.042500 | 8.46e-01 |
| Transport of Mature Transcript to Cytoplasm | 81 | 5.09e-01 | -0.042500 | 6.87e-01 |
| G0 and Early G1 | 27 | 7.03e-01 | -0.042400 | 8.23e-01 |
| Signaling by FGFR1 | 38 | 6.51e-01 | 0.042400 | 7.91e-01 |
| Signaling by Activin | 10 | 8.17e-01 | -0.042200 | 9.05e-01 |
| Peroxisomal protein import | 57 | 5.86e-01 | -0.041700 | 7.47e-01 |
| Ion channel transport | 136 | 4.02e-01 | -0.041600 | 5.99e-01 |
| RAB geranylgeranylation | 62 | 5.72e-01 | -0.041600 | 7.35e-01 |
| Export of Viral Ribonucleoproteins from Nucleus | 33 | 6.89e-01 | 0.040300 | 8.13e-01 |
| Signalling to RAS | 18 | 7.67e-01 | 0.040300 | 8.73e-01 |
| Rho GTPase cycle | 125 | 4.38e-01 | -0.040200 | 6.35e-01 |
| Transcriptional Regulation by VENTX | 38 | 6.68e-01 | -0.040200 | 7.99e-01 |
| ADP signalling through P2Y purinoceptor 12 | 18 | 7.71e-01 | 0.039600 | 8.77e-01 |
| Carboxyterminal post-translational modifications of tubulin | 27 | 7.27e-01 | -0.038900 | 8.39e-01 |
| IKK complex recruitment mediated by RIP1 | 23 | 7.50e-01 | 0.038300 | 8.58e-01 |
| O-linked glycosylation of mucins | 47 | 6.52e-01 | -0.038100 | 7.91e-01 |
| Initial triggering of complement | 78 | 5.61e-01 | -0.038100 | 7.27e-01 |
| Ion transport by P-type ATPases | 43 | 6.69e-01 | -0.037700 | 7.99e-01 |
| Interleukin-15 signaling | 14 | 8.09e-01 | -0.037400 | 9.01e-01 |
| Nuclear Envelope Breakdown | 53 | 6.41e-01 | 0.037000 | 7.87e-01 |
| G beta:gamma signalling through BTK | 15 | 8.04e-01 | 0.036900 | 8.98e-01 |
| Heme biosynthesis | 14 | 8.11e-01 | -0.036900 | 9.03e-01 |
| COPI-independent Golgi-to-ER retrograde traffic | 33 | 7.14e-01 | -0.036900 | 8.30e-01 |
| RNA polymerase II transcribes snRNA genes | 72 | 5.89e-01 | 0.036800 | 7.48e-01 |
| Synthesis, secretion, and deacylation of Ghrelin | 11 | 8.33e-01 | -0.036700 | 9.16e-01 |
| Apoptosis | 168 | 4.13e-01 | -0.036600 | 6.08e-01 |
| Regulation of RUNX2 expression and activity | 67 | 6.05e-01 | -0.036500 | 7.56e-01 |
| SUMOylation of DNA replication proteins | 46 | 6.69e-01 | 0.036400 | 7.99e-01 |
| Signal transduction by L1 | 20 | 7.79e-01 | 0.036300 | 8.80e-01 |
| Signaling by FGFR3 | 31 | 7.28e-01 | -0.036100 | 8.40e-01 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | 36 | 7.09e-01 | 0.036000 | 8.28e-01 |
| Diseases of mitotic cell cycle | 36 | 7.09e-01 | 0.036000 | 8.28e-01 |
| Deubiquitination | 242 | 3.40e-01 | -0.035600 | 5.45e-01 |
| Negative regulation of MET activity | 18 | 7.95e-01 | -0.035500 | 8.88e-01 |
| Receptor Mediated Mitophagy | 11 | 8.39e-01 | -0.035400 | 9.20e-01 |
| RAB GEFs exchange GTP for GDP on RABs | 87 | 5.68e-01 | -0.035400 | 7.32e-01 |
| Butyrophilin (BTN) family interactions | 10 | 8.47e-01 | -0.035300 | 9.25e-01 |
| Golgi Associated Vesicle Biogenesis | 55 | 6.52e-01 | -0.035200 | 7.91e-01 |
| Signaling by Rho GTPases | 365 | 2.50e-01 | -0.035000 | 4.52e-01 |
| Mitotic G1 phase and G1/S transition | 148 | 4.65e-01 | -0.034800 | 6.59e-01 |
| Processing of Intronless Pre-mRNAs | 19 | 7.95e-01 | -0.034500 | 8.88e-01 |
| Class I MHC mediated antigen processing & presentation | 349 | 2.69e-01 | -0.034400 | 4.71e-01 |
| Nitric oxide stimulates guanylate cyclase | 16 | 8.12e-01 | -0.034300 | 9.03e-01 |
| Signaling by Erythropoietin | 24 | 7.72e-01 | -0.034200 | 8.77e-01 |
| SHC1 events in EGFR signaling | 12 | 8.38e-01 | -0.034000 | 9.20e-01 |
| Peptide ligand-binding receptors | 97 | 5.63e-01 | -0.034000 | 7.28e-01 |
| Cytochrome P450 - arranged by substrate type | 36 | 7.26e-01 | 0.033800 | 8.39e-01 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 52 | 6.75e-01 | -0.033600 | 8.02e-01 |
| Oncogenic MAPK signaling | 73 | 6.24e-01 | 0.033200 | 7.72e-01 |
| G-protein activation | 23 | 7.83e-01 | 0.033200 | 8.82e-01 |
| Fanconi Anemia Pathway | 36 | 7.31e-01 | -0.033100 | 8.41e-01 |
| Myogenesis | 21 | 7.93e-01 | -0.033100 | 8.88e-01 |
| Nonhomologous End-Joining (NHEJ) | 42 | 7.12e-01 | -0.032900 | 8.29e-01 |
| Post-translational modification: synthesis of GPI-anchored proteins | 58 | 6.65e-01 | -0.032900 | 7.99e-01 |
| RHO GTPases activate KTN1 | 11 | 8.51e-01 | 0.032700 | 9.27e-01 |
| Biotin transport and metabolism | 11 | 8.51e-01 | -0.032600 | 9.27e-01 |
| Interleukin-37 signaling | 19 | 8.06e-01 | 0.032600 | 8.98e-01 |
| Acyl chain remodelling of PG | 11 | 8.53e-01 | -0.032400 | 9.27e-01 |
| Rap1 signalling | 13 | 8.40e-01 | 0.032400 | 9.21e-01 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | 18 | 8.13e-01 | 0.032200 | 9.03e-01 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | 80 | 6.20e-01 | -0.032100 | 7.70e-01 |
| Complement cascade | 98 | 5.88e-01 | -0.031600 | 7.48e-01 |
| Transport of bile salts and organic acids, metal ions and amine compounds | 55 | 6.90e-01 | 0.031100 | 8.14e-01 |
| Metabolism of cofactors | 19 | 8.22e-01 | 0.029900 | 9.07e-01 |
| Cyclin D associated events in G1 | 47 | 7.26e-01 | 0.029500 | 8.39e-01 |
| G1 Phase | 47 | 7.26e-01 | 0.029500 | 8.39e-01 |
| Cell recruitment (pro-inflammatory response) | 22 | 8.14e-01 | 0.029000 | 9.03e-01 |
| Purinergic signaling in leishmaniasis infection | 22 | 8.14e-01 | 0.029000 | 9.03e-01 |
| Activation of the pre-replicative complex | 32 | 7.77e-01 | -0.028900 | 8.80e-01 |
| Interactions of Vpr with host cellular proteins | 37 | 7.61e-01 | -0.028900 | 8.68e-01 |
| Meiosis | 68 | 6.82e-01 | -0.028800 | 8.09e-01 |
| Interleukin-10 signaling | 37 | 7.63e-01 | -0.028700 | 8.69e-01 |
| Muscle contraction | 144 | 5.56e-01 | -0.028400 | 7.24e-01 |
| Cytokine Signaling in Immune system | 738 | 1.92e-01 | -0.028200 | 3.93e-01 |
| Synthesis of PA | 32 | 7.83e-01 | -0.028200 | 8.82e-01 |
| tRNA processing in the nucleus | 59 | 7.11e-01 | -0.027900 | 8.29e-01 |
| Phase II - Conjugation of compounds | 67 | 6.95e-01 | 0.027700 | 8.17e-01 |
| Recruitment of NuMA to mitotic centrosomes | 80 | 6.69e-01 | -0.027700 | 7.99e-01 |
| Kinesins | 39 | 7.66e-01 | -0.027600 | 8.72e-01 |
| PERK regulates gene expression | 31 | 7.92e-01 | 0.027400 | 8.88e-01 |
| Cilium Assembly | 181 | 5.25e-01 | -0.027400 | 6.99e-01 |
| SLC-mediated transmembrane transport | 180 | 5.26e-01 | -0.027400 | 7.00e-01 |
| Ub-specific processing proteases | 171 | 5.38e-01 | -0.027300 | 7.10e-01 |
| Retinoid metabolism and transport | 24 | 8.18e-01 | -0.027200 | 9.05e-01 |
| DNA Damage Bypass | 47 | 7.49e-01 | -0.027000 | 8.58e-01 |
| Signaling by NTRK3 (TRKC) | 16 | 8.52e-01 | -0.026900 | 9.27e-01 |
| Centrosome maturation | 81 | 6.75e-01 | -0.026900 | 8.02e-01 |
| Recruitment of mitotic centrosome proteins and complexes | 81 | 6.75e-01 | -0.026900 | 8.02e-01 |
| Programmed Cell Death | 171 | 5.44e-01 | -0.026900 | 7.13e-01 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | 21 | 8.31e-01 | -0.026900 | 9.16e-01 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | 21 | 8.31e-01 | -0.026900 | 9.16e-01 |
| Processing of DNA double-strand break ends | 71 | 6.97e-01 | 0.026700 | 8.18e-01 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 79 | 6.83e-01 | 0.026600 | 8.09e-01 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 37 | 7.80e-01 | -0.026500 | 8.80e-01 |
| Negative regulators of DDX58/IFIH1 signaling | 34 | 7.91e-01 | 0.026300 | 8.88e-01 |
| Signaling by SCF-KIT | 40 | 7.75e-01 | -0.026100 | 8.78e-01 |
| Cardiac conduction | 93 | 6.69e-01 | 0.025700 | 7.99e-01 |
| Peroxisomal lipid metabolism | 27 | 8.19e-01 | 0.025400 | 9.05e-01 |
| Interleukin-6 signaling | 10 | 8.90e-01 | 0.025300 | 9.52e-01 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 104 | 6.62e-01 | 0.024800 | 7.97e-01 |
| Glutamate Neurotransmitter Release Cycle | 20 | 8.48e-01 | -0.024700 | 9.26e-01 |
| Intra-Golgi traffic | 43 | 7.80e-01 | -0.024600 | 8.80e-01 |
| CS/DS degradation | 10 | 8.95e-01 | -0.024100 | 9.54e-01 |
| Anchoring of the basal body to the plasma membrane | 97 | 6.83e-01 | 0.024000 | 8.09e-01 |
| NCAM signaling for neurite out-growth | 43 | 7.85e-01 | -0.024000 | 8.83e-01 |
| Termination of translesion DNA synthesis | 32 | 8.19e-01 | -0.023400 | 9.05e-01 |
| COPI-mediated anterograde transport | 78 | 7.27e-01 | -0.022900 | 8.39e-01 |
| Post-translational protein phosphorylation | 69 | 7.46e-01 | 0.022500 | 8.55e-01 |
| Vpr-mediated nuclear import of PICs | 34 | 8.20e-01 | 0.022500 | 9.06e-01 |
| RHO GTPase Effectors | 249 | 5.41e-01 | -0.022500 | 7.10e-01 |
| Mitotic Metaphase and Anaphase | 225 | 5.65e-01 | 0.022300 | 7.29e-01 |
| Signaling by FGFR in disease | 51 | 7.85e-01 | 0.022100 | 8.83e-01 |
| Xenobiotics | 12 | 8.96e-01 | -0.021700 | 9.54e-01 |
| SHC1 events in ERBB4 signaling | 10 | 9.08e-01 | -0.021100 | 9.60e-01 |
| Metabolism of steroids | 119 | 6.96e-01 | 0.020800 | 8.17e-01 |
| Beta-oxidation of very long chain fatty acids | 10 | 9.10e-01 | -0.020700 | 9.60e-01 |
| The NLRP3 inflammasome | 15 | 8.89e-01 | -0.020700 | 9.52e-01 |
| Interleukin-12 family signaling | 54 | 7.92e-01 | -0.020700 | 8.88e-01 |
| ATF6 (ATF6-alpha) activates chaperone genes | 10 | 9.10e-01 | 0.020600 | 9.60e-01 |
| ATF4 activates genes in response to endoplasmic reticulum stress | 26 | 8.63e-01 | 0.019600 | 9.36e-01 |
| Mitotic Anaphase | 224 | 6.18e-01 | 0.019300 | 7.69e-01 |
| Apoptotic cleavage of cellular proteins | 34 | 8.46e-01 | 0.019200 | 9.25e-01 |
| SUMOylation of transcription factors | 16 | 8.94e-01 | 0.019200 | 9.54e-01 |
| IRS-related events triggered by IGF1R | 35 | 8.46e-01 | -0.019000 | 9.25e-01 |
| Regulation of Complement cascade | 94 | 7.56e-01 | -0.018500 | 8.63e-01 |
| O-glycosylation of TSR domain-containing proteins | 28 | 8.67e-01 | -0.018200 | 9.40e-01 |
| cGMP effects | 13 | 9.11e-01 | -0.018000 | 9.60e-01 |
| Neurotransmitter release cycle | 37 | 8.50e-01 | 0.018000 | 9.27e-01 |
| AURKA Activation by TPX2 | 72 | 7.94e-01 | 0.017800 | 8.88e-01 |
| ADP signalling through P2Y purinoceptor 1 | 21 | 8.88e-01 | -0.017700 | 9.52e-01 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | 16 | 9.05e-01 | 0.017200 | 9.58e-01 |
| The phototransduction cascade | 26 | 8.79e-01 | -0.017200 | 9.45e-01 |
| G1/S-Specific Transcription | 29 | 8.76e-01 | 0.016700 | 9.45e-01 |
| Pyruvate metabolism | 28 | 8.80e-01 | 0.016500 | 9.45e-01 |
| Interleukin-2 family signaling | 38 | 8.60e-01 | -0.016500 | 9.34e-01 |
| Golgi-to-ER retrograde transport | 111 | 7.73e-01 | -0.015800 | 8.77e-01 |
| Prolonged ERK activation events | 13 | 9.22e-01 | 0.015700 | 9.66e-01 |
| Signalling to ERKs | 31 | 8.82e-01 | 0.015500 | 9.47e-01 |
| SHC1 events in ERBB2 signaling | 17 | 9.13e-01 | -0.015400 | 9.61e-01 |
| Interleukin-20 family signaling | 17 | 9.14e-01 | -0.015200 | 9.61e-01 |
| Signaling by BRAF and RAF fusions | 57 | 8.43e-01 | -0.015200 | 9.24e-01 |
| Signaling by ERBB2 in Cancer | 21 | 9.04e-01 | -0.015100 | 9.58e-01 |
| SUMOylation of SUMOylation proteins | 35 | 8.78e-01 | 0.015000 | 9.45e-01 |
| Postmitotic nuclear pore complex (NPC) reformation | 27 | 8.93e-01 | -0.015000 | 9.54e-01 |
| Signal amplification | 28 | 8.95e-01 | -0.014400 | 9.54e-01 |
| WNT ligand biogenesis and trafficking | 21 | 9.09e-01 | 0.014300 | 9.60e-01 |
| Initiation of Nuclear Envelope (NE) Reformation | 19 | 9.16e-01 | 0.014000 | 9.62e-01 |
| Signaling by GPCR | 547 | 5.80e-01 | -0.013800 | 7.41e-01 |
| Sema4D in semaphorin signaling | 22 | 9.11e-01 | 0.013700 | 9.60e-01 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 17 | 9.22e-01 | -0.013600 | 9.66e-01 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 16 | 9.27e-01 | 0.013200 | 9.67e-01 |
| Adherens junctions interactions | 17 | 9.26e-01 | 0.013000 | 9.67e-01 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | 63 | 8.60e-01 | -0.012900 | 9.34e-01 |
| G2/M Transition | 180 | 7.73e-01 | -0.012500 | 8.77e-01 |
| Signaling by ERBB2 KD Mutants | 20 | 9.24e-01 | -0.012400 | 9.66e-01 |
| COPII-mediated vesicle transport | 65 | 8.63e-01 | -0.012400 | 9.36e-01 |
| Assembly of active LPL and LIPC lipase complexes | 11 | 9.44e-01 | -0.012200 | 9.75e-01 |
| Nuclear import of Rev protein | 34 | 9.02e-01 | 0.012200 | 9.57e-01 |
| ER to Golgi Anterograde Transport | 129 | 8.12e-01 | -0.012100 | 9.03e-01 |
| Ca2+ pathway | 57 | 8.74e-01 | -0.012100 | 9.43e-01 |
| GPCR downstream signalling | 502 | 6.49e-01 | -0.011900 | 7.90e-01 |
| Retrograde transport at the Trans-Golgi-Network | 49 | 8.86e-01 | -0.011800 | 9.51e-01 |
| Potassium Channels | 66 | 8.74e-01 | -0.011300 | 9.43e-01 |
| activated TAK1 mediates p38 MAPK activation | 19 | 9.33e-01 | -0.011200 | 9.69e-01 |
| Inactivation, recovery and regulation of the phototransduction cascade | 25 | 9.24e-01 | -0.011100 | 9.66e-01 |
| Metabolism of steroid hormones | 20 | 9.33e-01 | 0.010800 | 9.69e-01 |
| SUMOylation of DNA damage response and repair proteins | 77 | 8.73e-01 | -0.010500 | 9.43e-01 |
| Cholesterol biosynthesis | 24 | 9.29e-01 | 0.010400 | 9.68e-01 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | 20 | 9.38e-01 | -0.010100 | 9.71e-01 |
| ECM proteoglycans | 36 | 9.18e-01 | 0.009900 | 9.63e-01 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | 55 | 9.00e-01 | -0.009840 | 9.56e-01 |
| Metabolism of vitamins and cofactors | 158 | 8.34e-01 | -0.009640 | 9.17e-01 |
| Eicosanoid ligand-binding receptors | 13 | 9.52e-01 | -0.009630 | 9.80e-01 |
| Signaling by MET | 61 | 8.97e-01 | 0.009580 | 9.54e-01 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 12 | 9.55e-01 | -0.009490 | 9.80e-01 |
| alpha-linolenic acid (ALA) metabolism | 12 | 9.55e-01 | -0.009490 | 9.80e-01 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | 12 | 9.55e-01 | -0.009370 | 9.80e-01 |
| Synthesis of glycosylphosphatidylinositol (GPI) | 17 | 9.50e-01 | 0.008760 | 9.80e-01 |
| Activation of GABAB receptors | 31 | 9.33e-01 | 0.008690 | 9.69e-01 |
| GABA B receptor activation | 31 | 9.33e-01 | 0.008690 | 9.69e-01 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | 25 | 9.40e-01 | 0.008630 | 9.73e-01 |
| Rev-mediated nuclear export of HIV RNA | 35 | 9.30e-01 | -0.008620 | 9.68e-01 |
| ATF6 (ATF6-alpha) activates chaperones | 12 | 9.60e-01 | 0.008460 | 9.82e-01 |
| Sphingolipid metabolism | 77 | 8.99e-01 | 0.008390 | 9.55e-01 |
| Homology Directed Repair | 110 | 8.79e-01 | 0.008380 | 9.45e-01 |
| DNA Double-Strand Break Repair | 135 | 8.73e-01 | 0.007980 | 9.43e-01 |
| TP53 Regulates Transcription of Cell Cycle Genes | 47 | 9.26e-01 | -0.007870 | 9.67e-01 |
| Stimuli-sensing channels | 75 | 9.08e-01 | 0.007700 | 9.60e-01 |
| Regulation of PLK1 Activity at G2/M Transition | 87 | 9.02e-01 | 0.007660 | 9.57e-01 |
| Activation of RAC1 | 11 | 9.65e-01 | 0.007540 | 9.82e-01 |
| IRAK1 recruits IKK complex | 10 | 9.68e-01 | 0.007340 | 9.82e-01 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 10 | 9.68e-01 | 0.007340 | 9.82e-01 |
| Metabolism of water-soluble vitamins and cofactors | 112 | 8.95e-01 | 0.007220 | 9.54e-01 |
| TP53 Regulates Transcription of Cell Death Genes | 43 | 9.36e-01 | 0.007110 | 9.70e-01 |
| TNFR1-induced NFkappaB signaling pathway | 25 | 9.51e-01 | 0.007060 | 9.80e-01 |
| Mitotic G2-G2/M phases | 182 | 8.70e-01 | -0.007040 | 9.42e-01 |
| COPI-dependent Golgi-to-ER retrograde traffic | 78 | 9.16e-01 | -0.006870 | 9.62e-01 |
| RUNX2 regulates bone development | 24 | 9.54e-01 | -0.006810 | 9.80e-01 |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 13 | 9.67e-01 | -0.006720 | 9.82e-01 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | 19 | 9.60e-01 | 0.006560 | 9.82e-01 |
| Glyoxylate metabolism and glycine degradation | 24 | 9.56e-01 | -0.006480 | 9.80e-01 |
| Diseases associated with the TLR signaling cascade | 23 | 9.57e-01 | -0.006470 | 9.80e-01 |
| Diseases of Immune System | 23 | 9.57e-01 | -0.006470 | 9.80e-01 |
| Phosphorylation of the APC/C | 20 | 9.62e-01 | -0.006220 | 9.82e-01 |
| Triglyceride catabolism | 16 | 9.66e-01 | -0.006140 | 9.82e-01 |
| Defective B3GALTL causes Peters-plus syndrome (PpS) | 27 | 9.62e-01 | -0.005280 | 9.82e-01 |
| Synthesis of PIPs at the Golgi membrane | 16 | 9.71e-01 | -0.005250 | 9.83e-01 |
| NOTCH2 intracellular domain regulates transcription | 11 | 9.76e-01 | -0.005230 | 9.88e-01 |
| Cell Cycle | 624 | 8.33e-01 | 0.004940 | 9.16e-01 |
| Formation of Incision Complex in GG-NER | 43 | 9.56e-01 | 0.004850 | 9.80e-01 |
| Loss of Nlp from mitotic centrosomes | 69 | 9.45e-01 | 0.004840 | 9.75e-01 |
| Loss of proteins required for interphase microtubule organization from the centrosome | 69 | 9.45e-01 | 0.004840 | 9.75e-01 |
| Metal ion SLC transporters | 21 | 9.71e-01 | -0.004570 | 9.83e-01 |
| G2/M Checkpoints | 139 | 9.26e-01 | -0.004540 | 9.67e-01 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | 14 | 9.77e-01 | -0.004460 | 9.88e-01 |
| Synthesis of very long-chain fatty acyl-CoAs | 22 | 9.71e-01 | 0.004450 | 9.83e-01 |
| Factors involved in megakaryocyte development and platelet production | 116 | 9.36e-01 | -0.004310 | 9.70e-01 |
| Formation of apoptosome | 11 | 9.82e-01 | 0.004010 | 9.89e-01 |
| Regulation of the apoptosome activity | 11 | 9.82e-01 | 0.004010 | 9.89e-01 |
| M Phase | 361 | 8.97e-01 | -0.003970 | 9.54e-01 |
| IGF1R signaling cascade | 36 | 9.67e-01 | -0.003960 | 9.82e-01 |
| Metabolism of folate and pterines | 17 | 9.78e-01 | 0.003930 | 9.88e-01 |
| Cargo trafficking to the periciliary membrane | 47 | 9.64e-01 | -0.003850 | 9.82e-01 |
| Sema4D induced cell migration and growth-cone collapse | 19 | 9.80e-01 | -0.003370 | 9.88e-01 |
| L1CAM interactions | 85 | 9.61e-01 | 0.003050 | 9.82e-01 |
| Glutathione conjugation | 26 | 9.79e-01 | 0.003040 | 9.88e-01 |
| Defects in vitamin and cofactor metabolism | 21 | 9.89e-01 | 0.001740 | 9.94e-01 |
| Insulin receptor signalling cascade | 39 | 9.86e-01 | -0.001670 | 9.92e-01 |
| Interactions of Rev with host cellular proteins | 37 | 9.86e-01 | 0.001650 | 9.92e-01 |
| Platelet Adhesion to exposed collagen | 13 | 9.92e-01 | -0.001650 | 9.95e-01 |
| Amino acid transport across the plasma membrane | 24 | 9.90e-01 | 0.001470 | 9.94e-01 |
| Heme degradation | 10 | 9.97e-01 | 0.000724 | 9.98e-01 |
| Metalloprotease DUBs | 21 | 9.96e-01 | 0.000627 | 9.98e-01 |
| Platelet sensitization by LDL | 16 | 9.97e-01 | 0.000486 | 9.98e-01 |
| IRS-mediated signalling | 34 | 9.98e-01 | 0.000298 | 9.98e-01 |
| Cell Cycle, Mitotic | 502 | 9.96e-01 | -0.000115 | 9.98e-01 |
Detailed Gene set reports
Peptide chain elongation
| 809 | |
|---|---|
| set | Peptide chain elongation |
| setSize | 88 |
| pANOVA | 1.04e-44 |
| s.dist | -0.863 |
| p.adjustANOVA | 5.85e-42 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| EEF2 | -9164 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| EEF1A1 | -8699 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| RPS27L | 8894 |
| RPL3L | 10929 |
| RPS4Y1 | 12763 |
Eukaryotic Translation Elongation
| 352 | |
|---|---|
| set | Eukaryotic Translation Elongation |
| setSize | 93 |
| pANOVA | 1.22e-46 |
| s.dist | -0.858 |
| p.adjustANOVA | 1.66e-43 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| EEF1G | -9328 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| EEF1B2 | -9281 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| EEF1G | -9328 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| EEF1B2 | -9281 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| EEF1D | -9170 |
| EEF2 | -9164 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| EEF1A1 | -8699 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| EEF1A1P5 | -7306 |
| RPL9 | -7271 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| EEF1A2 | 1186 |
| RPS27L | 8894 |
| RPL3L | 10929 |
| RPS4Y1 | 12763 |
Viral mRNA Translation
| 1316 | |
|---|---|
| set | Viral mRNA Translation |
| setSize | 88 |
| pANOVA | 6.81e-42 |
| s.dist | -0.835 |
| p.adjustANOVA | 1.86e-39 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| GRSF1 | 2013 |
| DNAJC3 | 7895 |
| RPS27L | 8894 |
| RPL3L | 10929 |
| RPS4Y1 | 12763 |
Eukaryotic Translation Termination
| 354 | |
|---|---|
| set | Eukaryotic Translation Termination |
| setSize | 92 |
| pANOVA | 1.49e-42 |
| s.dist | -0.823 |
| p.adjustANOVA | 5.09e-40 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| TRMT112 | -9274 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| TRMT112 | -9274 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| APEH | -7112 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| GSPT2 | -6078 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| N6AMT1 | -2783 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| ETF1 | 7750 |
| RPS27L | 8894 |
| GSPT1 | 9355 |
| RPL3L | 10929 |
| RPS4Y1 | 12763 |
Formation of a pool of free 40S subunits
| 394 | |
|---|---|
| set | Formation of a pool of free 40S subunits |
| setSize | 100 |
| pANOVA | 1.29e-44 |
| s.dist | -0.809 |
| p.adjustANOVA | 5.85e-42 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| EIF3F | -9241 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| EIF3C | -8987 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| EIF3I | -8392 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| EIF3D | -8004 |
| RPL34 | -7929 |
| EIF3B | -7853 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| EIF3K | -7122 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| EIF3H | -6227 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| EIF3E | 1417 |
| EIF1AX | 2485 |
| EIF3A | 3853 |
| EIF3M | 5545 |
| RPS27L | 8894 |
| EIF3J | 9265 |
| RPL3L | 10929 |
| RPS4Y1 | 12763 |
Selenocysteine synthesis
| 1061 | |
|---|---|
| set | Selenocysteine synthesis |
| setSize | 92 |
| pANOVA | 5.23e-41 |
| s.dist | -0.807 |
| p.adjustANOVA | 1.19e-38 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| SARS1 | -6720 |
| SEPHS2 | -6588 |
| RPL26L1 | -6526 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| EEFSEC | -2910 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| PSTK | 1600 |
| RPS27L | 8894 |
| SEPSECS | 10889 |
| RPL3L | 10929 |
| SECISBP2 | 11468 |
| RPS4Y1 | 12763 |
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
| 745 | |
|---|---|
| set | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| setSize | 94 |
| pANOVA | 1.13e-38 |
| s.dist | -0.775 |
| p.adjustANOVA | 1.44e-36 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| GSPT2 | -6078 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| EIF4G1 | -4627 |
| UPF1 | -4542 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| PABPC1 | 4676 |
| ETF1 | 7750 |
| RPS27L | 8894 |
| GSPT1 | 9355 |
| NCBP2 | 9598 |
| RPL3L | 10929 |
| NCBP1 | 11061 |
| RPS4Y1 | 12763 |
L13a-mediated translational silencing of Ceruloplasmin expression
| 590 | |
|---|---|
| set | L13a-mediated translational silencing of Ceruloplasmin expression |
| setSize | 110 |
| pANOVA | 7.75e-41 |
| s.dist | -0.737 |
| p.adjustANOVA | 1.51e-38 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| EIF3F | -9241 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| EIF3C | -8987 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| EIF4H | -8739 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| EIF3I | -8392 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| EIF3D | -8004 |
| RPL34 | -7929 |
| EIF3B | -7853 |
| EIF4B | -7834 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| EIF3K | -7122 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| EIF3H | -6227 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| EIF4G1 | -4627 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| EIF4A1 | -807 |
| EIF3E | 1417 |
| EIF1AX | 2485 |
| EIF4A2 | 3187 |
| EIF3A | 3853 |
| PABPC1 | 4676 |
| EIF2S3 | 5397 |
| EIF3M | 5545 |
| EIF2S1 | 6183 |
| RPS27L | 8894 |
| EIF2S2 | 8941 |
| EIF3J | 9265 |
| EIF4E | 9328 |
| RPL3L | 10929 |
| RPS4Y1 | 12763 |
GTP hydrolysis and joining of the 60S ribosomal subunit
| 436 | |
|---|---|
| set | GTP hydrolysis and joining of the 60S ribosomal subunit |
| setSize | 111 |
| pANOVA | 1.28e-39 |
| s.dist | -0.722 |
| p.adjustANOVA | 2.19e-37 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| EIF3F | -9241 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| EIF3C | -8987 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| EIF4H | -8739 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| EIF3I | -8392 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| EIF3D | -8004 |
| RPL34 | -7929 |
| EIF3B | -7853 |
| EIF4B | -7834 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| EIF3K | -7122 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| EIF3H | -6227 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| EIF4G1 | -4627 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| EIF4A1 | -807 |
| EIF3E | 1417 |
| EIF1AX | 2485 |
| EIF4A2 | 3187 |
| EIF3A | 3853 |
| EIF2S3 | 5397 |
| EIF3M | 5545 |
| EIF5 | 6148 |
| EIF2S1 | 6183 |
| RPS27L | 8894 |
| EIF2S2 | 8941 |
| EIF3J | 9265 |
| EIF4E | 9328 |
| EIF5B | 10235 |
| RPL3L | 10929 |
| RPS4Y1 | 12763 |
Response of EIF2AK4 (GCN2) to amino acid deficiency
| 1009 | |
|---|---|
| set | Response of EIF2AK4 (GCN2) to amino acid deficiency |
| setSize | 100 |
| pANOVA | 1.34e-34 |
| s.dist | -0.709 |
| p.adjustANOVA | 1.52e-32 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| ATF4 | -4454 |
| EIF2AK4 | -3699 |
| GCN1 | -3522 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| CEBPB | 84 |
| DDIT3 | 2799 |
| ASNS | 3900 |
| TRIB3 | 4310 |
| EIF2S3 | 5397 |
| CEBPG | 5933 |
| EIF2S1 | 6183 |
| RPS27L | 8894 |
| EIF2S2 | 8941 |
| IMPACT | 10444 |
| RPL3L | 10929 |
| ATF2 | 10943 |
| ATF3 | 11788 |
| RPS4Y1 | 12763 |
Cap-dependent Translation Initiation
| 145 | |
|---|---|
| set | Cap-dependent Translation Initiation |
| setSize | 118 |
| pANOVA | 1.16e-38 |
| s.dist | -0.692 |
| p.adjustANOVA | 1.44e-36 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| EIF3F | -9241 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| EIF3C | -8987 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| EIF4H | -8739 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| EIF3I | -8392 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| EIF3D | -8004 |
| RPL34 | -7929 |
| EIF3B | -7853 |
| EIF4B | -7834 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| EIF3K | -7122 |
| EIF2B2 | -6988 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| EIF3H | -6227 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| EIF2B4 | -5527 |
| EIF4G1 | -4627 |
| EIF4EBP1 | -4048 |
| EIF2B5 | -2814 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| EIF4A1 | -807 |
| EIF3E | 1417 |
| EIF1AX | 2485 |
| EIF4A2 | 3187 |
| EIF3A | 3853 |
| PABPC1 | 4676 |
| EIF2S3 | 5397 |
| EIF2B1 | 5427 |
| EIF2B3 | 5429 |
| EIF3M | 5545 |
| EIF5 | 6148 |
| EIF2S1 | 6183 |
| RPS27L | 8894 |
| EIF2S2 | 8941 |
| EIF3J | 9265 |
| EIF4E | 9328 |
| EIF5B | 10235 |
| RPL3L | 10929 |
| RPS4Y1 | 12763 |
Eukaryotic Translation Initiation
| 353 | |
|---|---|
| set | Eukaryotic Translation Initiation |
| setSize | 118 |
| pANOVA | 1.16e-38 |
| s.dist | -0.692 |
| p.adjustANOVA | 1.44e-36 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| EIF3F | -9241 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| EIF3C | -8987 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| EIF4H | -8739 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| EIF3I | -8392 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| EIF3D | -8004 |
| RPL34 | -7929 |
| EIF3B | -7853 |
| EIF4B | -7834 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| EIF3K | -7122 |
| EIF2B2 | -6988 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| EIF3H | -6227 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| EIF2B4 | -5527 |
| EIF4G1 | -4627 |
| EIF4EBP1 | -4048 |
| EIF2B5 | -2814 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| EIF4A1 | -807 |
| EIF3E | 1417 |
| EIF1AX | 2485 |
| EIF4A2 | 3187 |
| EIF3A | 3853 |
| PABPC1 | 4676 |
| EIF2S3 | 5397 |
| EIF2B1 | 5427 |
| EIF2B3 | 5429 |
| EIF3M | 5545 |
| EIF5 | 6148 |
| EIF2S1 | 6183 |
| RPS27L | 8894 |
| EIF2S2 | 8941 |
| EIF3J | 9265 |
| EIF4E | 9328 |
| EIF5B | 10235 |
| RPL3L | 10929 |
| RPS4Y1 | 12763 |
SRP-dependent cotranslational protein targeting to membrane
| 1041 | |
|---|---|
| set | SRP-dependent cotranslational protein targeting to membrane |
| setSize | 111 |
| pANOVA | 1.07e-33 |
| s.dist | -0.664 |
| p.adjustANOVA | 9.13e-32 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| SEC61B | -8770 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| DDOST | -8473 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| SSR4 | -7121 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| SSR2 | -6581 |
| RPL26L1 | -6526 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| SPCS1 | -4245 |
| RPN1 | -3732 |
| SRPRA | -2588 |
| SEC11A | -1921 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| SRP68 | -1340 |
| SEC61A1 | -1055 |
| SRP14 | 419 |
| RPN2 | 1383 |
| SRPRB | 2167 |
| SRP9 | 4053 |
| SSR1 | 4321 |
| SRP72 | 4960 |
| SSR3 | 6159 |
| SPCS2 | 6229 |
| SEC61G | 6364 |
| SEC61A2 | 6567 |
| SEC11C | 7454 |
| RPS27L | 8894 |
| TRAM1 | 9094 |
| SPCS3 | 10349 |
| RPL3L | 10929 |
| SRP19 | 11751 |
| SRP54 | 12051 |
| RPS4Y1 | 12763 |
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
| 744 | |
|---|---|
| set | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| setSize | 114 |
| pANOVA | 1e-33 |
| s.dist | -0.655 |
| p.adjustANOVA | 9.12e-32 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| MAGOH | -9296 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| MAGOH | -9296 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| PPP2R1A | -8336 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| RPL39L | -6939 |
| EIF4A3 | -6926 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| RBM8A | -6424 |
| GSPT2 | -6078 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| CASC3 | -5146 |
| SMG6 | -5064 |
| SMG5 | -4938 |
| RNPS1 | -4925 |
| EIF4G1 | -4627 |
| UPF1 | -4542 |
| SMG9 | -3243 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| UPF3A | -951 |
| PPP2CA | 470 |
| SMG8 | 3382 |
| MAGOHB | 4286 |
| PABPC1 | 4676 |
| SMG1 | 5569 |
| DCP1A | 5794 |
| ETF1 | 7750 |
| SMG7 | 8426 |
| UPF3B | 8627 |
| RPS27L | 8894 |
| GSPT1 | 9355 |
| NCBP2 | 9598 |
| PNRC2 | 9985 |
| UPF2 | 10589 |
| RPL3L | 10929 |
| NCBP1 | 11061 |
| PPP2R2A | 12336 |
| RPS4Y1 | 12763 |
Nonsense-Mediated Decay (NMD)
| 746 | |
|---|---|
| set | Nonsense-Mediated Decay (NMD) |
| setSize | 114 |
| pANOVA | 1e-33 |
| s.dist | -0.655 |
| p.adjustANOVA | 9.12e-32 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| MAGOH | -9296 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| MAGOH | -9296 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| PPP2R1A | -8336 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| RPL39L | -6939 |
| EIF4A3 | -6926 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| RBM8A | -6424 |
| GSPT2 | -6078 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| CASC3 | -5146 |
| SMG6 | -5064 |
| SMG5 | -4938 |
| RNPS1 | -4925 |
| EIF4G1 | -4627 |
| UPF1 | -4542 |
| SMG9 | -3243 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| UPF3A | -951 |
| PPP2CA | 470 |
| SMG8 | 3382 |
| MAGOHB | 4286 |
| PABPC1 | 4676 |
| SMG1 | 5569 |
| DCP1A | 5794 |
| ETF1 | 7750 |
| SMG7 | 8426 |
| UPF3B | 8627 |
| RPS27L | 8894 |
| GSPT1 | 9355 |
| NCBP2 | 9598 |
| PNRC2 | 9985 |
| UPF2 | 10589 |
| RPL3L | 10929 |
| NCBP1 | 11061 |
| PPP2R2A | 12336 |
| RPS4Y1 | 12763 |
Formation of the ternary complex, and subsequently, the 43S complex
| 400 | |
|---|---|
| set | Formation of the ternary complex, and subsequently, the 43S complex |
| setSize | 51 |
| pANOVA | 1.28e-15 |
| s.dist | -0.647 |
| p.adjustANOVA | 5e-14 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPS11 | -9278 |
| RPS27 | -9262 |
| EIF3F | -9241 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPS5 | -9195 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPS23 | -9032 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPS11 | -9278 |
| RPS27 | -9262 |
| EIF3F | -9241 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPS5 | -9195 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPS23 | -9032 |
| EIF3C | -8987 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPS13 | -8921 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPS15 | -8688 |
| EIF3I | -8392 |
| RPS9 | -8346 |
| RPS8 | -8300 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| EIF3D | -8004 |
| EIF3B | -7853 |
| EIF3K | -7122 |
| RPS3A | -6738 |
| EIF3H | -6227 |
| RPS24 | -5639 |
| RPSA | -1714 |
| RPS26 | -1506 |
| EIF3E | 1417 |
| EIF1AX | 2485 |
| EIF3A | 3853 |
| EIF2S3 | 5397 |
| EIF3M | 5545 |
| EIF2S1 | 6183 |
| RPS27L | 8894 |
| EIF2S2 | 8941 |
| EIF3J | 9265 |
| RPS4Y1 | 12763 |
Selenoamino acid metabolism
| 1060 | |
|---|---|
| set | Selenoamino acid metabolism |
| setSize | 114 |
| pANOVA | 1.59e-30 |
| s.dist | -0.622 |
| p.adjustANOVA | 1.14e-28 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| AHCY | -8504 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| QARS1 | -8378 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| SARS1 | -6720 |
| SEPHS2 | -6588 |
| RPL26L1 | -6526 |
| RPL28 | -5887 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| SCLY | -4408 |
| EEFSEC | -2910 |
| GSR | -2903 |
| TXNRD1 | -1971 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| GNMT | -1423 |
| EEF1E1 | -329 |
| PSTK | 1600 |
| IARS1 | 1693 |
| HNMT | 1972 |
| PAPSS1 | 3471 |
| AIMP2 | 3530 |
| INMT | 5367 |
| MARS1 | 5416 |
| EPRS1 | 5581 |
| KARS1 | 5618 |
| CTH | 7230 |
| LARS1 | 8416 |
| RPS27L | 8894 |
| DARS1 | 10424 |
| CBS | 10480 |
| AIMP1 | 10500 |
| SEPSECS | 10889 |
| RPL3L | 10929 |
| RARS1 | 11354 |
| SECISBP2 | 11468 |
| PAPSS2 | 12537 |
| RPS4Y1 | 12763 |
Influenza Viral RNA Transcription and Replication
| 529 | |
|---|---|
| set | Influenza Viral RNA Transcription and Replication |
| setSize | 135 |
| pANOVA | 3.52e-33 |
| s.dist | -0.597 |
| p.adjustANOVA | 2.82e-31 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| POLR2L | -9320 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| POLR2L | -9320 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| POLR2F | -8986 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| POLR2I | -8796 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| POLR2G | -8692 |
| RPS15 | -8688 |
| POLR2E | -8653 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| POLR2J | -8559 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| POLR2H | -8250 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| RPL9 | -7271 |
| RPL39L | -6939 |
| PARP1 | -6837 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| POM121C | -6039 |
| RPL28 | -5887 |
| SEC13 | -5872 |
| NUP210 | -5843 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| NUP188 | -4967 |
| POM121 | -4856 |
| AAAS | -4530 |
| NUP62 | -3555 |
| IPO5 | -3106 |
| NUP35 | -2863 |
| NUP88 | -1890 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| NUP37 | -1452 |
| RAE1 | -977 |
| NUP205 | -213 |
| POLR2A | 147 |
| NUP98 | 234 |
| NDC1 | 290 |
| NUP153 | 654 |
| NUP133 | 1439 |
| POLR2B | 1638 |
| GRSF1 | 2013 |
| GTF2F2 | 2060 |
| NUP214 | 2063 |
| NUP160 | 3404 |
| NUP85 | 4353 |
| POLR2D | 4368 |
| NUP155 | 4907 |
| POLR2K | 5408 |
| SEH1L | 6428 |
| HSP90AA1 | 6784 |
| DNAJC3 | 7895 |
| RANBP2 | 8289 |
| NUP58 | 8368 |
| RPS27L | 8894 |
| NUP93 | 9377 |
| NUP50 | 9465 |
| TPR | 9515 |
| NUP107 | 9552 |
| NUP43 | 9977 |
| RPL3L | 10929 |
| NUP42 | 11138 |
| NUP54 | 11884 |
| RPS4Y1 | 12763 |
Translation initiation complex formation
| 1270 | |
|---|---|
| set | Translation initiation complex formation |
| setSize | 58 |
| pANOVA | 4.37e-15 |
| s.dist | -0.595 |
| p.adjustANOVA | 1.61e-13 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPS11 | -9278 |
| RPS27 | -9262 |
| EIF3F | -9241 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPS5 | -9195 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPS23 | -9032 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPS11 | -9278 |
| RPS27 | -9262 |
| EIF3F | -9241 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPS5 | -9195 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPS23 | -9032 |
| EIF3C | -8987 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPS13 | -8921 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| EIF4H | -8739 |
| RPS15 | -8688 |
| EIF3I | -8392 |
| RPS9 | -8346 |
| RPS8 | -8300 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| EIF3D | -8004 |
| EIF3B | -7853 |
| EIF4B | -7834 |
| EIF3K | -7122 |
| RPS3A | -6738 |
| EIF3H | -6227 |
| RPS24 | -5639 |
| EIF4G1 | -4627 |
| RPSA | -1714 |
| RPS26 | -1506 |
| EIF4A1 | -807 |
| EIF3E | 1417 |
| EIF1AX | 2485 |
| EIF4A2 | 3187 |
| EIF3A | 3853 |
| PABPC1 | 4676 |
| EIF2S3 | 5397 |
| EIF3M | 5545 |
| EIF2S1 | 6183 |
| RPS27L | 8894 |
| EIF2S2 | 8941 |
| EIF3J | 9265 |
| EIF4E | 9328 |
| RPS4Y1 | 12763 |
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
| 50 | |
|---|---|
| set | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| setSize | 59 |
| pANOVA | 2.91e-15 |
| s.dist | -0.594 |
| p.adjustANOVA | 1.1e-13 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPS11 | -9278 |
| RPS27 | -9262 |
| EIF3F | -9241 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPS5 | -9195 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPS23 | -9032 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPS11 | -9278 |
| RPS27 | -9262 |
| EIF3F | -9241 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPS5 | -9195 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPS23 | -9032 |
| EIF3C | -8987 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPS13 | -8921 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| EIF4H | -8739 |
| RPS15 | -8688 |
| EIF3I | -8392 |
| RPS9 | -8346 |
| RPS8 | -8300 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| EIF3D | -8004 |
| EIF3B | -7853 |
| EIF4B | -7834 |
| EIF3K | -7122 |
| RPS3A | -6738 |
| EIF3H | -6227 |
| RPS24 | -5639 |
| EIF4G1 | -4627 |
| EIF4EBP1 | -4048 |
| RPSA | -1714 |
| RPS26 | -1506 |
| EIF4A1 | -807 |
| EIF3E | 1417 |
| EIF1AX | 2485 |
| EIF4A2 | 3187 |
| EIF3A | 3853 |
| PABPC1 | 4676 |
| EIF2S3 | 5397 |
| EIF3M | 5545 |
| EIF2S1 | 6183 |
| RPS27L | 8894 |
| EIF2S2 | 8941 |
| EIF3J | 9265 |
| EIF4E | 9328 |
| RPS4Y1 | 12763 |
Ribosomal scanning and start codon recognition
| 1017 | |
|---|---|
| set | Ribosomal scanning and start codon recognition |
| setSize | 58 |
| pANOVA | 5.56e-15 |
| s.dist | -0.593 |
| p.adjustANOVA | 2e-13 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPS11 | -9278 |
| RPS27 | -9262 |
| EIF3F | -9241 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPS5 | -9195 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPS23 | -9032 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPS11 | -9278 |
| RPS27 | -9262 |
| EIF3F | -9241 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPS5 | -9195 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| RPS25 | -9056 |
| RPS23 | -9032 |
| EIF3C | -8987 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPS13 | -8921 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| EIF4H | -8739 |
| RPS15 | -8688 |
| EIF3I | -8392 |
| RPS9 | -8346 |
| RPS8 | -8300 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| EIF3D | -8004 |
| EIF3B | -7853 |
| EIF4B | -7834 |
| EIF3K | -7122 |
| RPS3A | -6738 |
| EIF3H | -6227 |
| RPS24 | -5639 |
| EIF4G1 | -4627 |
| RPSA | -1714 |
| RPS26 | -1506 |
| EIF4A1 | -807 |
| EIF3E | 1417 |
| EIF1AX | 2485 |
| EIF4A2 | 3187 |
| EIF3A | 3853 |
| EIF2S3 | 5397 |
| EIF3M | 5545 |
| EIF5 | 6148 |
| EIF2S1 | 6183 |
| RPS27L | 8894 |
| EIF2S2 | 8941 |
| EIF3J | 9265 |
| EIF4E | 9328 |
| RPS4Y1 | 12763 |
VLDLR internalisation and degradation
| 1311 | |
|---|---|
| set | VLDLR internalisation and degradation |
| setSize | 11 |
| pANOVA | 0.00121 |
| s.dist | -0.563 |
| p.adjustANOVA | 0.0121 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| AP2M1 | -8551 |
| AP2A2 | -7462 |
| NR1H3 | -7454 |
| MYLIP | -6772 |
| NR1H2 | -6193 |
| AP2S1 | -5881 |
| AP2B1 | -3883 |
| CLTA | -3628 |
| VLDLR | -1105 |
| AP2A1 | 323 |
| CLTC | 797 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| AP2M1 | -8551 |
| AP2A2 | -7462 |
| NR1H3 | -7454 |
| MYLIP | -6772 |
| NR1H2 | -6193 |
| AP2S1 | -5881 |
| AP2B1 | -3883 |
| CLTA | -3628 |
| VLDLR | -1105 |
| AP2A1 | 323 |
| CLTC | 797 |
Formation of ATP by chemiosmotic coupling
| 386 | |
|---|---|
| set | Formation of ATP by chemiosmotic coupling |
| setSize | 18 |
| pANOVA | 3.7e-05 |
| s.dist | -0.562 |
| p.adjustANOVA | 0.000581 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| ATP5MG | -9147 |
| ATP5ME | -9120 |
| MT-ATP8 | -8945 |
| ATP5MF | -8794 |
| ATP5F1D | -8754 |
| ATP5MC2 | -8170 |
| ATP5F1A | -7067 |
| ATP5F1E | -6990 |
| MT-ATP6 | -6906 |
| ATP5MC3 | -6871 |
| ATP5PB | -6434 |
| ATP5PF | -5589 |
| ATP5PO | -3155 |
| ATP5MC1 | -2555 |
| ATP5F1B | -1757 |
| ATP5PD | 2098 |
| ATP5F1C | 5853 |
| DMAC2L | 11208 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| ATP5MG | -9147 |
| ATP5ME | -9120 |
| MT-ATP8 | -8945 |
| ATP5MF | -8794 |
| ATP5F1D | -8754 |
| ATP5MC2 | -8170 |
| ATP5F1A | -7067 |
| ATP5F1E | -6990 |
| MT-ATP6 | -6906 |
| ATP5MC3 | -6871 |
| ATP5PB | -6434 |
| ATP5PF | -5589 |
| ATP5PO | -3155 |
| ATP5MC1 | -2555 |
| ATP5F1B | -1757 |
| ATP5PD | 2098 |
| ATP5F1C | 5853 |
| DMAC2L | 11208 |
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
| 1325 | |
|---|---|
| set | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
| setSize | 11 |
| pANOVA | 0.00225 |
| s.dist | -0.532 |
| p.adjustANOVA | 0.02 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| ROR1 | -9199 |
| CLTB | -8674 |
| AP2M1 | -8551 |
| AP2A2 | -7462 |
| AP2S1 | -5881 |
| FZD2 | -5701 |
| AP2B1 | -3883 |
| CLTA | -3628 |
| AP2A1 | 323 |
| CLTC | 797 |
| FZD5 | 5894 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| ROR1 | -9199 |
| CLTB | -8674 |
| AP2M1 | -8551 |
| AP2A2 | -7462 |
| AP2S1 | -5881 |
| FZD2 | -5701 |
| AP2B1 | -3883 |
| CLTA | -3628 |
| AP2A1 | 323 |
| CLTC | 797 |
| FZD5 | 5894 |
Pausing and recovery of Tat-mediated HIV elongation
| 807 | |
|---|---|
| set | Pausing and recovery of Tat-mediated HIV elongation |
| setSize | 30 |
| pANOVA | 9.6e-07 |
| s.dist | -0.517 |
| p.adjustANOVA | 2.15e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| CDK9 | -8934 |
| NELFB | -8842 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| ELOB | -8383 |
| POLR2H | -8250 |
| CTDP1 | -7881 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| SSRP1 | -6970 |
| ELL | -6868 |
| SUPT5H | -5989 |
| NELFE | -5284 |
| SUPT4H1 | -2488 |
| NELFA | -2374 |
| ELOC | -2008 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| CDK9 | -8934 |
| NELFB | -8842 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| ELOB | -8383 |
| POLR2H | -8250 |
| CTDP1 | -7881 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| SSRP1 | -6970 |
| ELL | -6868 |
| SUPT5H | -5989 |
| NELFE | -5284 |
| SUPT4H1 | -2488 |
| NELFA | -2374 |
| ELOC | -2008 |
| CCNT1 | -821 |
| SUPT16H | -696 |
| NELFCD | -428 |
| POLR2A | 147 |
| POLR2B | 1638 |
| GTF2F2 | 2060 |
| POLR2D | 4368 |
| ELOA | 4517 |
| POLR2K | 5408 |
| TCEA1 | 5602 |
Tat-mediated HIV elongation arrest and recovery
| 1218 | |
|---|---|
| set | Tat-mediated HIV elongation arrest and recovery |
| setSize | 30 |
| pANOVA | 9.6e-07 |
| s.dist | -0.517 |
| p.adjustANOVA | 2.15e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| CDK9 | -8934 |
| NELFB | -8842 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| ELOB | -8383 |
| POLR2H | -8250 |
| CTDP1 | -7881 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| SSRP1 | -6970 |
| ELL | -6868 |
| SUPT5H | -5989 |
| NELFE | -5284 |
| SUPT4H1 | -2488 |
| NELFA | -2374 |
| ELOC | -2008 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| CDK9 | -8934 |
| NELFB | -8842 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| ELOB | -8383 |
| POLR2H | -8250 |
| CTDP1 | -7881 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| SSRP1 | -6970 |
| ELL | -6868 |
| SUPT5H | -5989 |
| NELFE | -5284 |
| SUPT4H1 | -2488 |
| NELFA | -2374 |
| ELOC | -2008 |
| CCNT1 | -821 |
| SUPT16H | -696 |
| NELFCD | -428 |
| POLR2A | 147 |
| POLR2B | 1638 |
| GTF2F2 | 2060 |
| POLR2D | 4368 |
| ELOA | 4517 |
| POLR2K | 5408 |
| TCEA1 | 5602 |
Regulation of expression of SLITs and ROBOs
| 982 | |
|---|---|
| set | Regulation of expression of SLITs and ROBOs |
| setSize | 162 |
| pANOVA | 8.66e-30 |
| s.dist | -0.515 |
| p.adjustANOVA | 5.91e-28 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| MAGOH | -9296 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| MAGOH | -9296 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| ROBO3 | -9197 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| PSMB6 | -8886 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| LDB1 | -8678 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| ELOB | -8383 |
| PSMD2 | -8380 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| PSMB7 | -8306 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| PSMD9 | -8273 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| PSMC5 | -8197 |
| PSMB5 | -8188 |
| RPS4X | -8156 |
| PSMD3 | -8115 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| PSMC3 | -7569 |
| RPL13 | -7444 |
| PSMD4 | -7418 |
| RPL9 | -7271 |
| PSMD8 | -7130 |
| PSMB4 | -7001 |
| RPL39L | -6939 |
| EIF4A3 | -6926 |
| UBB | -6801 |
| SEM1 | -6746 |
| RPS3A | -6738 |
| PSMC4 | -6544 |
| RPL26L1 | -6526 |
| RBM8A | -6424 |
| ROBO1 | -6198 |
| GSPT2 | -6078 |
| RPL28 | -5887 |
| PSMB10 | -5875 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| ZSWIM8 | -5535 |
| CASC3 | -5146 |
| SLIT1 | -5127 |
| PSMD13 | -5048 |
| RNPS1 | -4925 |
| EIF4G1 | -4627 |
| PSMB1 | -4370 |
| PSMA7 | -4354 |
| PSMF1 | -4035 |
| PSMB3 | -3936 |
| DAG1 | -2080 |
| PSMA2 | -2019 |
| ELOC | -2008 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| UPF3A | -951 |
| PSMC1 | 19 |
| UBC | 972 |
| PSME3 | 1597 |
| PSMB9 | 1806 |
| RBX1 | 1943 |
| PSMB8 | 2230 |
| PSMA5 | 2637 |
| PSMA1 | 3078 |
| PSMD6 | 3171 |
| PSMA8 | 3456 |
| PSMB2 | 3837 |
| PSMD10 | 3948 |
| PSME1 | 4213 |
| MAGOHB | 4286 |
| PSMD7 | 4566 |
| PABPC1 | 4676 |
| LHX4 | 4711 |
| PSMC2 | 5256 |
| MSI1 | 5752 |
| PSMD14 | 5767 |
| PSME4 | 7120 |
| PSMD1 | 7192 |
| ETF1 | 7750 |
| PSMD11 | 8277 |
| UPF3B | 8627 |
| RPS27L | 8894 |
| CUL2 | 9352 |
| GSPT1 | 9355 |
| PSMC6 | 9427 |
| NCBP2 | 9598 |
| PSME2 | 10327 |
| UPF2 | 10589 |
| PSMA6 | 10593 |
| HOXA2 | 10630 |
| PSMD5 | 10855 |
| RPL3L | 10929 |
| NCBP1 | 11061 |
| PSMA4 | 11585 |
| USP33 | 11756 |
| PSMA3 | 12436 |
| PSMD12 | 12488 |
| RPS4Y1 | 12763 |
Influenza Infection
| 528 | |
|---|---|
| set | Influenza Infection |
| setSize | 154 |
| pANOVA | 1.01e-27 |
| s.dist | -0.509 |
| p.adjustANOVA | 6.28e-26 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| SLC25A6 | -9360 |
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| POLR2L | -9320 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| SLC25A6 | -9360 |
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| POLR2L | -9320 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| POLR2F | -8986 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| POLR2I | -8796 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| POLR2G | -8692 |
| RPS15 | -8688 |
| POLR2E | -8653 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| POLR2J | -8559 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| POLR2H | -8250 |
| RPS4X | -8156 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| RPL13 | -7444 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| RPL9 | -7271 |
| RPL39L | -6939 |
| PARP1 | -6837 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| CPSF4 | -6476 |
| TGFB1 | -6221 |
| POM121C | -6039 |
| PABPN1 | -5954 |
| RPL28 | -5887 |
| SEC13 | -5872 |
| NUP210 | -5843 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| HSPA1A | -5222 |
| NUP188 | -4967 |
| POM121 | -4856 |
| AAAS | -4530 |
| RAN | -3967 |
| CLTA | -3628 |
| NUP62 | -3555 |
| IPO5 | -3106 |
| NUP35 | -2863 |
| NUP88 | -1890 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| NUP37 | -1452 |
| RAE1 | -977 |
| NUP205 | -213 |
| POLR2A | 147 |
| NUP98 | 234 |
| NDC1 | 290 |
| NUP153 | 654 |
| CLTC | 797 |
| NUP133 | 1439 |
| POLR2B | 1638 |
| GRSF1 | 2013 |
| GTF2F2 | 2060 |
| NUP214 | 2063 |
| NUP160 | 3404 |
| CANX | 3650 |
| CALR | 4088 |
| NUP85 | 4353 |
| POLR2D | 4368 |
| NUP155 | 4907 |
| POLR2K | 5408 |
| SEH1L | 6428 |
| KPNA1 | 6723 |
| HSP90AA1 | 6784 |
| DNAJC3 | 7895 |
| KPNA2 | 8284 |
| RANBP2 | 8289 |
| NUP58 | 8368 |
| KPNA3 | 8633 |
| RPS27L | 8894 |
| KPNA4 | 9200 |
| KPNB1 | 9270 |
| NUP93 | 9377 |
| NUP50 | 9465 |
| TPR | 9515 |
| NUP107 | 9552 |
| NUP43 | 9977 |
| RPL3L | 10929 |
| NUP42 | 11138 |
| KPNA5 | 11319 |
| XPO1 | 11750 |
| NUP54 | 11884 |
| ISG15 | 12412 |
| EIF2AK2 | 12747 |
| RPS4Y1 | 12763 |
Josephin domain DUBs
| 584 | |
|---|---|
| set | Josephin domain DUBs |
| setSize | 10 |
| pANOVA | 0.00616 |
| s.dist | -0.5 |
| p.adjustANOVA | 0.041 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| JOSD2 | -7956 |
| UBB | -6801 |
| VCP | -6462 |
| RAD23A | -4290 |
| JOSD1 | -3994 |
| RAD23B | -1708 |
| UBC | 972 |
| ATXN3 | 10147 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| JOSD2 | -7956 |
| UBB | -6801 |
| VCP | -6462 |
| RAD23A | -4290 |
| JOSD1 | -3994 |
| RAD23B | -1708 |
| UBC | 972 |
| ATXN3 | 10147 |
RNA Polymerase I Promoter Opening
| 903 | |
|---|---|
| set | RNA Polymerase I Promoter Opening |
| setSize | 19 |
| pANOVA | 0.000284 |
| s.dist | -0.481 |
| p.adjustANOVA | 0.00352 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MAPK3 | -9318.0 |
| H2AZ1 | -8900.0 |
| UBTF | -8388.0 |
| H2BC12 | -7886.0 |
| H2AZ2 | -7692.0 |
| H2AJ | -7409.0 |
| H3C15 | -5601.5 |
| H2BC5 | -5076.0 |
| H2BC11 | -4577.0 |
| H2BC15 | -4551.0 |
| H2BC9 | -2948.0 |
| H2AC6 | -2807.0 |
| H2BC17 | -2534.0 |
| H2BC21 | -2274.0 |
| H2BU1 | -1593.0 |
| H2BC4 | -607.0 |
| H3-3A | 1111.0 |
| H2AC20 | 3617.0 |
| MBD2 | 8776.0 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MAPK3 | -9318.0 |
| H2AZ1 | -8900.0 |
| UBTF | -8388.0 |
| H2BC12 | -7886.0 |
| H2AZ2 | -7692.0 |
| H2AJ | -7409.0 |
| H3C15 | -5601.5 |
| H2BC5 | -5076.0 |
| H2BC11 | -4577.0 |
| H2BC15 | -4551.0 |
| H2BC9 | -2948.0 |
| H2AC6 | -2807.0 |
| H2BC17 | -2534.0 |
| H2BC21 | -2274.0 |
| H2BU1 | -1593.0 |
| H2BC4 | -607.0 |
| H3-3A | 1111.0 |
| H2AC20 | 3617.0 |
| MBD2 | 8776.0 |
WNT5A-dependent internalization of FZD4
| 1326 | |
|---|---|
| set | WNT5A-dependent internalization of FZD4 |
| setSize | 13 |
| pANOVA | 0.00268 |
| s.dist | -0.481 |
| p.adjustANOVA | 0.022 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| CLTB | -8674 |
| AP2M1 | -8551 |
| DVL2 | -8471 |
| AP2A2 | -7462 |
| AP2S1 | -5881 |
| ARRB2 | -4930 |
| PRKCA | -4088 |
| AP2B1 | -3883 |
| CLTA | -3628 |
| PRKCB | -859 |
| AP2A1 | 323 |
| CLTC | 797 |
| FZD4 | 8315 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| CLTB | -8674 |
| AP2M1 | -8551 |
| DVL2 | -8471 |
| AP2A2 | -7462 |
| AP2S1 | -5881 |
| ARRB2 | -4930 |
| PRKCA | -4088 |
| AP2B1 | -3883 |
| CLTA | -3628 |
| PRKCB | -859 |
| AP2A1 | 323 |
| CLTC | 797 |
| FZD4 | 8315 |
Olfactory Signaling Pathway
| 767 | |
|---|---|
| set | Olfactory Signaling Pathway |
| setSize | 61 |
| pANOVA | 1.27e-10 |
| s.dist | 0.476 |
| p.adjustANOVA | 3.95e-09 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| OR2AT4 | 12694 |
| OR2M3 | 12674 |
| OR2G6 | 12557 |
| OR5AS1 | 12445 |
| OR8A1 | 12427 |
| OR10G3 | 12237 |
| OR6Y1 | 12220 |
| OR2V2 | 12190 |
| OR2A5 | 12077 |
| OR7C1 | 12070 |
| RTP4 | 12004 |
| OR10H5 | 11972 |
| OR6C75 | 11814 |
| OR1D2 | 11728 |
| OR52N4 | 11632 |
| OR10A6 | 11552 |
| OR1C1 | 11451 |
| REEP3 | 11419 |
| OR5A2 | 11308 |
| OR7A5 | 11266 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| OR2AT4 | 12694 |
| OR2M3 | 12674 |
| OR2G6 | 12557 |
| OR5AS1 | 12445 |
| OR8A1 | 12427 |
| OR10G3 | 12237 |
| OR6Y1 | 12220 |
| OR2V2 | 12190 |
| OR2A5 | 12077 |
| OR7C1 | 12070 |
| RTP4 | 12004 |
| OR10H5 | 11972 |
| OR6C75 | 11814 |
| OR1D2 | 11728 |
| OR52N4 | 11632 |
| OR10A6 | 11552 |
| OR1C1 | 11451 |
| REEP3 | 11419 |
| OR5A2 | 11308 |
| OR7A5 | 11266 |
| OR4K17 | 11181 |
| OR1I1 | 11107 |
| OR52K1 | 11056 |
| OR14J1 | 11017 |
| OR5A1 | 10873 |
| OR2C3 | 10769 |
| OR7D4 | 10464 |
| OR2M4 | 10304 |
| OR6K3 | 9864 |
| OR7G2 | 9714 |
| OR14L1P | 9423 |
| OR2L2 | 9336 |
| OR4E1 | 8849 |
| OR2H2 | 8703 |
| OR4D9 | 8629 |
| OR51L1 | 8365 |
| OR2I1P | 7977 |
| OR2T33 | 7691 |
| OR2W3 | 6994 |
| OR5AU1 | 4915 |
| OR56A1 | 4544 |
| OR1A1 | 4507 |
| OR5AN1 | 4098 |
| OR1M1 | 3759 |
| OR52A1 | 3713 |
| OR7A17 | 3627 |
| REEP2 | 3411 |
| OR2B11 | 2373 |
| OR7D2 | 821 |
| RTP5 | -234 |
| REEP5 | -297 |
| OR3A3 | -458 |
| OR10AC1 | -1175 |
| GNAL | -1975 |
| GNB1 | -2587 |
| OR2A7 | -2865 |
| OR2A1 | -3156 |
| REEP4 | -3241 |
| REEP1 | -4010 |
| OR4D1 | -4992 |
| REEP6 | -8853 |
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
| 1190 | |
|---|---|
| set | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| setSize | 16 |
| pANOVA | 0.00103 |
| s.dist | -0.474 |
| p.adjustANOVA | 0.0106 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| PARD6A | -9070 |
| UBA52 | -8911 |
| TGFBR2 | -8545 |
| PRKCZ | -8189 |
| UBB | -6801 |
| TGFB1 | -6221 |
| CGN | -6065 |
| F11R | -5744 |
| ARHGEF18 | -5614 |
| UBC | 972 |
| PARD3 | 1253 |
| TGFBR1 | 2995 |
| FKBP1A | 3246 |
| SMURF1 | 4380 |
| RHOA | 5028 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| PARD6A | -9070 |
| UBA52 | -8911 |
| TGFBR2 | -8545 |
| PRKCZ | -8189 |
| UBB | -6801 |
| TGFB1 | -6221 |
| CGN | -6065 |
| F11R | -5744 |
| ARHGEF18 | -5614 |
| UBC | 972 |
| PARD3 | 1253 |
| TGFBR1 | 2995 |
| FKBP1A | 3246 |
| SMURF1 | 4380 |
| RHOA | 5028 |
rRNA processing in the nucleus and cytosol
| 1357 | |
|---|---|
| set | rRNA processing in the nucleus and cytosol |
| setSize | 190 |
| pANOVA | 1.93e-29 |
| s.dist | -0.473 |
| p.adjustANOVA | 1.26e-27 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| FBL | -9294 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| TRMT112 | -9274 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| FBL | -9294 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| TRMT112 | -9274 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| TSR3 | -9224 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| WDR46 | -9068 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| EXOSC7 | -9011 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RRP9 | -8642 |
| BYSL | -8606 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| SNU13 | -8555 |
| NHP2 | -8521 |
| RPL13A | -8497 |
| PES1 | -8482 |
| RPL21 | -8453 |
| BOP1 | -8438 |
| RPL11 | -8400 |
| RPP21 | -8396 |
| IMP4 | -8357 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| CSNK1D | -8129 |
| RPL23A | -8104 |
| EXOSC5 | -8064 |
| RPL10A | -8026 |
| IMP3 | -8018 |
| NOP2 | -7940 |
| RPL34 | -7929 |
| DDX49 | -7792 |
| NOP10 | -7566 |
| NOB1 | -7535 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| CSNK1E | -7197 |
| TBL3 | -7083 |
| RPL39L | -6939 |
| EXOSC4 | -6797 |
| EXOSC2 | -6778 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| NOL12 | -6106 |
| LAS1L | -6010 |
| RPL28 | -5887 |
| WDR18 | -5675 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| NCL | -5389 |
| PDCD11 | -5347 |
| UTP3 | -5213 |
| EBNA1BP2 | -5156 |
| NOL6 | -5139 |
| DKC1 | -5133 |
| DHX37 | -5052 |
| NAT10 | -4979 |
| RPP25 | -4709 |
| RCL1 | -4664 |
| NOP14 | -4521 |
| NOP56 | -4399 |
| RRP7A | -4306 |
| PELP1 | -3976 |
| SENP3 | -3654 |
| RRP36 | -3476 |
| BMS1 | -3168 |
| GAR1 | -2826 |
| PWP2 | -2386 |
| RPSA | -1714 |
| DCAF13 | -1646 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| WDR43 | -1410 |
| WDR3 | -976 |
| UTP4 | -150 |
| EXOSC6 | -74 |
| RBM28 | -68 |
| FTSJ3 | 179 |
| XRN2 | 551 |
| UTP18 | 601 |
| RIOK1 | 1288 |
| NIP7 | 1692 |
| GNL3 | 1731 |
| EXOSC3 | 1827 |
| LTV1 | 2073 |
| TSR1 | 2174 |
| HEATR1 | 2279 |
| UTP14A | 2306 |
| NOC4L | 2407 |
| EMG1 | 2771 |
| EXOSC8 | 2903 |
| RPP40 | 3254 |
| DDX47 | 3604 |
| MPHOSPH6 | 3703 |
| RPP38 | 3738 |
| NOL11 | 3744 |
| FCF1 | 4127 |
| EXOSC1 | 4181 |
| RRP1 | 4199 |
| ISG20L2 | 4735 |
| WDR36 | 5116 |
| WDR12 | 5123 |
| EXOSC10 | 5124 |
| UTP6 | 5712 |
| RPP14 | 5931 |
| MTREX | 6034 |
| UTP11 | 6035 |
| KRR1 | 6371 |
| RPP30 | 6939 |
| WDR75 | 7427 |
| THUMPD1 | 7507 |
| UTP20 | 7577 |
| UTP14C | 7812 |
| NOP58 | 7845 |
| NOL9 | 7953 |
| DIMT1 | 8351 |
| RPS27L | 8894 |
| SNORD3A | 9432 |
| EXOSC9 | 9878 |
| PNO1 | 9895 |
| RIOK2 | 9990 |
| UTP15 | 10205 |
| TEX10 | 10407 |
| DDX21 | 10704 |
| C1D | 10763 |
| RPL3L | 10929 |
| MPHOSPH10 | 11648 |
| DIS3 | 11958 |
| RIOK3 | 12065 |
| ERI1 | 12304 |
| DDX52 | 12731 |
| RPS4Y1 | 12763 |
Major pathway of rRNA processing in the nucleolus and cytosol
| 627 | |
|---|---|
| set | Major pathway of rRNA processing in the nucleolus and cytosol |
| setSize | 180 |
| pANOVA | 1.07e-27 |
| s.dist | -0.471 |
| p.adjustANOVA | 6.37e-26 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| FBL | -9294 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| FBL | -9294 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| WDR46 | -9068 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| EXOSC7 | -9011 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RRP9 | -8642 |
| BYSL | -8606 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| SNU13 | -8555 |
| RPL13A | -8497 |
| PES1 | -8482 |
| RPL21 | -8453 |
| BOP1 | -8438 |
| RPL11 | -8400 |
| RPP21 | -8396 |
| IMP4 | -8357 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| CSNK1D | -8129 |
| RPL23A | -8104 |
| EXOSC5 | -8064 |
| RPL10A | -8026 |
| IMP3 | -8018 |
| RPL34 | -7929 |
| DDX49 | -7792 |
| NOB1 | -7535 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| CSNK1E | -7197 |
| TBL3 | -7083 |
| RPL39L | -6939 |
| EXOSC4 | -6797 |
| EXOSC2 | -6778 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| NOL12 | -6106 |
| LAS1L | -6010 |
| RPL28 | -5887 |
| WDR18 | -5675 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| NCL | -5389 |
| PDCD11 | -5347 |
| UTP3 | -5213 |
| EBNA1BP2 | -5156 |
| NOL6 | -5139 |
| DHX37 | -5052 |
| RPP25 | -4709 |
| RCL1 | -4664 |
| NOP14 | -4521 |
| NOP56 | -4399 |
| RRP7A | -4306 |
| PELP1 | -3976 |
| SENP3 | -3654 |
| RRP36 | -3476 |
| BMS1 | -3168 |
| PWP2 | -2386 |
| RPSA | -1714 |
| DCAF13 | -1646 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| WDR43 | -1410 |
| WDR3 | -976 |
| UTP4 | -150 |
| EXOSC6 | -74 |
| RBM28 | -68 |
| FTSJ3 | 179 |
| XRN2 | 551 |
| UTP18 | 601 |
| RIOK1 | 1288 |
| NIP7 | 1692 |
| GNL3 | 1731 |
| EXOSC3 | 1827 |
| LTV1 | 2073 |
| TSR1 | 2174 |
| HEATR1 | 2279 |
| UTP14A | 2306 |
| NOC4L | 2407 |
| EMG1 | 2771 |
| EXOSC8 | 2903 |
| RPP40 | 3254 |
| DDX47 | 3604 |
| MPHOSPH6 | 3703 |
| RPP38 | 3738 |
| NOL11 | 3744 |
| FCF1 | 4127 |
| EXOSC1 | 4181 |
| RRP1 | 4199 |
| ISG20L2 | 4735 |
| WDR36 | 5116 |
| WDR12 | 5123 |
| EXOSC10 | 5124 |
| UTP6 | 5712 |
| RPP14 | 5931 |
| MTREX | 6034 |
| UTP11 | 6035 |
| KRR1 | 6371 |
| RPP30 | 6939 |
| WDR75 | 7427 |
| UTP20 | 7577 |
| UTP14C | 7812 |
| NOP58 | 7845 |
| NOL9 | 7953 |
| RPS27L | 8894 |
| SNORD3A | 9432 |
| EXOSC9 | 9878 |
| PNO1 | 9895 |
| RIOK2 | 9990 |
| UTP15 | 10205 |
| TEX10 | 10407 |
| DDX21 | 10704 |
| C1D | 10763 |
| RPL3L | 10929 |
| MPHOSPH10 | 11648 |
| DIS3 | 11958 |
| RIOK3 | 12065 |
| ERI1 | 12304 |
| DDX52 | 12731 |
| RPS4Y1 | 12763 |
DNA methylation
| 247 | |
|---|---|
| set | DNA methylation |
| setSize | 20 |
| pANOVA | 0.00027 |
| s.dist | -0.47 |
| p.adjustANOVA | 0.00339 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900.0 |
| H2BC12 | -7886.0 |
| H2AZ2 | -7692.0 |
| H2AJ | -7409.0 |
| DNMT3A | -7229.0 |
| DNMT1 | -5812.0 |
| H3C15 | -5601.5 |
| H2BC5 | -5076.0 |
| H2BC11 | -4577.0 |
| H2BC15 | -4551.0 |
| DNMT3B | -3110.0 |
| H2BC9 | -2948.0 |
| H2AC6 | -2807.0 |
| H2BC17 | -2534.0 |
| H2BC21 | -2274.0 |
| H2BU1 | -1593.0 |
| H2BC4 | -607.0 |
| H3-3A | 1111.0 |
| H2AC20 | 3617.0 |
| UHRF1 | 5941.0 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900.0 |
| H2BC12 | -7886.0 |
| H2AZ2 | -7692.0 |
| H2AJ | -7409.0 |
| DNMT3A | -7229.0 |
| DNMT1 | -5812.0 |
| H3C15 | -5601.5 |
| H2BC5 | -5076.0 |
| H2BC11 | -4577.0 |
| H2BC15 | -4551.0 |
| DNMT3B | -3110.0 |
| H2BC9 | -2948.0 |
| H2AC6 | -2807.0 |
| H2BC17 | -2534.0 |
| H2BC21 | -2274.0 |
| H2BU1 | -1593.0 |
| H2BC4 | -607.0 |
| H3-3A | 1111.0 |
| H2AC20 | 3617.0 |
| UHRF1 | 5941.0 |
rRNA processing
| 1355 | |
|---|---|
| set | rRNA processing |
| setSize | 219 |
| pANOVA | 8.95e-32 |
| s.dist | -0.459 |
| p.adjustANOVA | 6.79e-30 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| FBL | -9294 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| TRMT112 | -9274 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| FBL | -9294 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| TRMT112 | -9274 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| TSR3 | -9224 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| WDR46 | -9068 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| EXOSC7 | -9011 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| MT-ATP8 | -8945 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| RRP9 | -8642 |
| BYSL | -8606 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| SNU13 | -8555 |
| NHP2 | -8521 |
| RPL13A | -8497 |
| PES1 | -8482 |
| RPL21 | -8453 |
| BOP1 | -8438 |
| RPL11 | -8400 |
| RPP21 | -8396 |
| IMP4 | -8357 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| CSNK1D | -8129 |
| RPL23A | -8104 |
| EXOSC5 | -8064 |
| RPL10A | -8026 |
| IMP3 | -8018 |
| NOP2 | -7940 |
| RPL34 | -7929 |
| MRM1 | -7820 |
| DDX49 | -7792 |
| MT-CO3 | -7585 |
| NOP10 | -7566 |
| NOB1 | -7535 |
| RPL13 | -7444 |
| RPL9 | -7271 |
| CSNK1E | -7197 |
| TBL3 | -7083 |
| MTERF4 | -6960 |
| RPL39L | -6939 |
| MT-ATP6 | -6906 |
| EXOSC4 | -6797 |
| EXOSC2 | -6778 |
| RPS3A | -6738 |
| RPL26L1 | -6526 |
| HSD17B10 | -6363 |
| MT-ND3 | -6232 |
| NOL12 | -6106 |
| LAS1L | -6010 |
| ELAC2 | -5953 |
| RPL28 | -5887 |
| MT-TV | -5819 |
| WDR18 | -5675 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| MT-ND4L | -5454 |
| NCL | -5389 |
| PDCD11 | -5347 |
| UTP3 | -5213 |
| EBNA1BP2 | -5156 |
| NOL6 | -5139 |
| DKC1 | -5133 |
| DHX37 | -5052 |
| NAT10 | -4979 |
| RPP25 | -4709 |
| MT-CO2 | -4684 |
| RCL1 | -4664 |
| NOP14 | -4521 |
| MRM3 | -4475 |
| NOP56 | -4399 |
| MT-TF | -4357 |
| RRP7A | -4306 |
| PELP1 | -3976 |
| MT-TM | -3832 |
| MT-TL2 | -3777 |
| SENP3 | -3654 |
| RRP36 | -3476 |
| MT-ND1 | -3379 |
| BMS1 | -3168 |
| GAR1 | -2826 |
| PWP2 | -2386 |
| MRM2 | -2325 |
| RPSA | -1714 |
| DCAF13 | -1646 |
| RPL22L1 | -1618 |
| RPS26 | -1506 |
| MT-CYB | -1416 |
| WDR43 | -1410 |
| MT-ND2 | -1038 |
| WDR3 | -976 |
| MT-ND5 | -825 |
| UTP4 | -150 |
| EXOSC6 | -74 |
| RBM28 | -68 |
| MT-RNR1 | 149 |
| MT-CO1 | 171 |
| FTSJ3 | 179 |
| XRN2 | 551 |
| UTP18 | 601 |
| MT-RNR2 | 677 |
| MT-TL1 | 1060 |
| RIOK1 | 1288 |
| NIP7 | 1692 |
| GNL3 | 1731 |
| EXOSC3 | 1827 |
| LTV1 | 2073 |
| TSR1 | 2174 |
| HEATR1 | 2279 |
| UTP14A | 2306 |
| NOC4L | 2407 |
| EMG1 | 2771 |
| EXOSC8 | 2903 |
| PRORP | 3101 |
| RPP40 | 3254 |
| DDX47 | 3604 |
| MPHOSPH6 | 3703 |
| RPP38 | 3738 |
| NOL11 | 3744 |
| FCF1 | 4127 |
| EXOSC1 | 4181 |
| RRP1 | 4199 |
| TFB1M | 4233 |
| ISG20L2 | 4735 |
| WDR36 | 5116 |
| WDR12 | 5123 |
| EXOSC10 | 5124 |
| UTP6 | 5712 |
| RPP14 | 5931 |
| MTREX | 6034 |
| UTP11 | 6035 |
| KRR1 | 6371 |
| TRMT10C | 6586 |
| RPP30 | 6939 |
| MT-ND4 | 7163 |
| WDR75 | 7427 |
| THUMPD1 | 7507 |
| UTP20 | 7577 |
| UTP14C | 7812 |
| NOP58 | 7845 |
| NOL9 | 7953 |
| DIMT1 | 8351 |
| RPS27L | 8894 |
| NSUN4 | 9005 |
| SNORD3A | 9432 |
| EXOSC9 | 9878 |
| PNO1 | 9895 |
| RIOK2 | 9990 |
| UTP15 | 10205 |
| TEX10 | 10407 |
| DDX21 | 10704 |
| C1D | 10763 |
| RPL3L | 10929 |
| MPHOSPH10 | 11648 |
| DIS3 | 11958 |
| RIOK3 | 12065 |
| ERI1 | 12304 |
| DDX52 | 12731 |
| RPS4Y1 | 12763 |
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
| 717 | |
|---|---|
| set | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| setSize | 21 |
| pANOVA | 0.000334 |
| s.dist | -0.452 |
| p.adjustANOVA | 0.00406 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| HLA-A | -9042 |
| AP2M1 | -8551 |
| AP1M1 | -8099 |
| AP2A2 | -7462 |
| LCK | -7236 |
| AP1S1 | -7234 |
| ARF1 | -6757 |
| CD28 | -6478 |
| PACS1 | -6471 |
| AP2S1 | -5881 |
| AP1B1 | -4779 |
| CD4 | -4377 |
| AP2B1 | -3883 |
| ATP6V1H | -2263 |
| AP1M2 | -2193 |
| CD8B | 250 |
| AP2A1 | 323 |
| AP1S3 | 2906 |
| AP1G1 | 3191 |
| B2M | 6409 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| HLA-A | -9042 |
| AP2M1 | -8551 |
| AP1M1 | -8099 |
| AP2A2 | -7462 |
| LCK | -7236 |
| AP1S1 | -7234 |
| ARF1 | -6757 |
| CD28 | -6478 |
| PACS1 | -6471 |
| AP2S1 | -5881 |
| AP1B1 | -4779 |
| CD4 | -4377 |
| AP2B1 | -3883 |
| ATP6V1H | -2263 |
| AP1M2 | -2193 |
| CD8B | 250 |
| AP2A1 | 323 |
| AP1S3 | 2906 |
| AP1G1 | 3191 |
| B2M | 6409 |
| AP1S2 | 8413 |
Pexophagy
| 815 | |
|---|---|
| set | Pexophagy |
| setSize | 11 |
| pANOVA | 0.00966 |
| s.dist | -0.451 |
| p.adjustANOVA | 0.0551 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| SQSTM1 | -8420 |
| USP30 | -7491 |
| UBB | -6801 |
| PEX5 | -6034 |
| NBR1 | -85 |
| MAP1LC3B | 43 |
| ATM | 53 |
| UBC | 972 |
| EPAS1 | 9874 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| SQSTM1 | -8420 |
| USP30 | -7491 |
| UBB | -6801 |
| PEX5 | -6034 |
| NBR1 | -85 |
| MAP1LC3B | 43 |
| ATM | 53 |
| UBC | 972 |
| EPAS1 | 9874 |
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
| 331 | |
|---|---|
| set | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
| setSize | 32 |
| pANOVA | 1.04e-05 |
| s.dist | -0.45 |
| p.adjustANOVA | 0.000189 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900.0 |
| CHD3 | -8299.0 |
| EHMT2 | -8187.0 |
| MBD3 | -8181.0 |
| H2BC12 | -7886.0 |
| H2AZ2 | -7692.0 |
| H2AJ | -7409.0 |
| MTA3 | -7109.0 |
| HDAC1 | -7004.0 |
| MTA1 | -6635.0 |
| ERCC6 | -5884.0 |
| MTA2 | -5860.0 |
| H3C15 | -5601.5 |
| H2BC5 | -5076.0 |
| GATAD2A | -4830.0 |
| CHD4 | -4769.0 |
| H2BC11 | -4577.0 |
| H2BC15 | -4551.0 |
| H2BC9 | -2948.0 |
| H2AC6 | -2807.0 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900.0 |
| CHD3 | -8299.0 |
| EHMT2 | -8187.0 |
| MBD3 | -8181.0 |
| H2BC12 | -7886.0 |
| H2AZ2 | -7692.0 |
| H2AJ | -7409.0 |
| MTA3 | -7109.0 |
| HDAC1 | -7004.0 |
| MTA1 | -6635.0 |
| ERCC6 | -5884.0 |
| MTA2 | -5860.0 |
| H3C15 | -5601.5 |
| H2BC5 | -5076.0 |
| GATAD2A | -4830.0 |
| CHD4 | -4769.0 |
| H2BC11 | -4577.0 |
| H2BC15 | -4551.0 |
| H2BC9 | -2948.0 |
| H2AC6 | -2807.0 |
| H2BC17 | -2534.0 |
| H2BC21 | -2274.0 |
| RBBP7 | -2001.0 |
| H2BU1 | -1593.0 |
| H2BC4 | -607.0 |
| HDAC2 | 439.0 |
| RBBP4 | 1097.0 |
| H3-3A | 1111.0 |
| GATAD2B | 3024.0 |
| H2AC20 | 3617.0 |
| TTF1 | 9498.0 |
| CBX3 | 9719.0 |
Abortive elongation of HIV-1 transcript in the absence of Tat
| 29 | |
|---|---|
| set | Abortive elongation of HIV-1 transcript in the absence of Tat |
| setSize | 23 |
| pANOVA | 0.000193 |
| s.dist | -0.449 |
| p.adjustANOVA | 0.00252 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| NELFB | -8842 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| POLR2H | -8250 |
| CTDP1 | -7881 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| SUPT5H | -5989 |
| NELFE | -5284 |
| SUPT4H1 | -2488 |
| NELFA | -2374 |
| NELFCD | -428 |
| POLR2A | 147 |
| POLR2B | 1638 |
| GTF2F2 | 2060 |
| POLR2D | 4368 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| NELFB | -8842 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| POLR2H | -8250 |
| CTDP1 | -7881 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| SUPT5H | -5989 |
| NELFE | -5284 |
| SUPT4H1 | -2488 |
| NELFA | -2374 |
| NELFCD | -428 |
| POLR2A | 147 |
| POLR2B | 1638 |
| GTF2F2 | 2060 |
| POLR2D | 4368 |
| POLR2K | 5408 |
| NCBP2 | 9598 |
| NCBP1 | 11061 |
Class C/3 (Metabotropic glutamate/pheromone receptors)
| 188 | |
|---|---|
| set | Class C/3 (Metabotropic glutamate/pheromone receptors) |
| setSize | 11 |
| pANOVA | 0.0109 |
| s.dist | 0.443 |
| p.adjustANOVA | 0.0605 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| TAS2R14 | 11484 |
| TAS2R20 | 10870 |
| GRM6 | 10646 |
| GRM2 | 9752 |
| TAS2R3 | 7891 |
| TAS2R30 | 7479 |
| GABBR1 | 7104 |
| TAS2R4 | 6605 |
| TAS1R3 | 3392 |
| CASR | 172 |
| TAS2R5 | -2765 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| TAS2R14 | 11484 |
| TAS2R20 | 10870 |
| GRM6 | 10646 |
| GRM2 | 9752 |
| TAS2R3 | 7891 |
| TAS2R30 | 7479 |
| GABBR1 | 7104 |
| TAS2R4 | 6605 |
| TAS1R3 | 3392 |
| CASR | 172 |
| TAS2R5 | -2765 |
Cristae formation
| 220 | |
|---|---|
| set | Cristae formation |
| setSize | 31 |
| pANOVA | 2.16e-05 |
| s.dist | -0.441 |
| p.adjustANOVA | 0.00036 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| ATP5MG | -9147 |
| ATP5ME | -9120 |
| MT-ATP8 | -8945 |
| ATP5MF | -8794 |
| ATP5F1D | -8754 |
| MICOS13 | -8737 |
| CHCHD6 | -8362 |
| ATP5MC2 | -8170 |
| SAMM50 | -7810 |
| ATP5F1A | -7067 |
| ATP5F1E | -6990 |
| MT-ATP6 | -6906 |
| ATP5MC3 | -6871 |
| MTX1 | -6820 |
| ATP5PB | -6434 |
| ATP5PF | -5589 |
| ATP5PO | -3155 |
| TMEM11 | -3147 |
| ATP5MC1 | -2555 |
| DNAJC11 | -2289 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| ATP5MG | -9147 |
| ATP5ME | -9120 |
| MT-ATP8 | -8945 |
| ATP5MF | -8794 |
| ATP5F1D | -8754 |
| MICOS13 | -8737 |
| CHCHD6 | -8362 |
| ATP5MC2 | -8170 |
| SAMM50 | -7810 |
| ATP5F1A | -7067 |
| ATP5F1E | -6990 |
| MT-ATP6 | -6906 |
| ATP5MC3 | -6871 |
| MTX1 | -6820 |
| ATP5PB | -6434 |
| ATP5PF | -5589 |
| ATP5PO | -3155 |
| TMEM11 | -3147 |
| ATP5MC1 | -2555 |
| DNAJC11 | -2289 |
| MICOS10 | -2235 |
| ATP5F1B | -1757 |
| HSPA9 | -1103 |
| CHCHD3 | -182 |
| ATP5PD | 2098 |
| APOO | 4059 |
| MTX2 | 4274 |
| ATP5F1C | 5853 |
| IMMT | 7034 |
| APOOL | 8252 |
| DMAC2L | 11208 |
HIV elongation arrest and recovery
| 486 | |
|---|---|
| set | HIV elongation arrest and recovery |
| setSize | 32 |
| pANOVA | 1.86e-05 |
| s.dist | -0.437 |
| p.adjustANOVA | 0.000314 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| CDK9 | -8934 |
| NELFB | -8842 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| ELOB | -8383 |
| POLR2H | -8250 |
| CTDP1 | -7881 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| SSRP1 | -6970 |
| ELL | -6868 |
| SUPT5H | -5989 |
| NELFE | -5284 |
| SUPT4H1 | -2488 |
| NELFA | -2374 |
| ELOC | -2008 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| CDK9 | -8934 |
| NELFB | -8842 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| ELOB | -8383 |
| POLR2H | -8250 |
| CTDP1 | -7881 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| SSRP1 | -6970 |
| ELL | -6868 |
| SUPT5H | -5989 |
| NELFE | -5284 |
| SUPT4H1 | -2488 |
| NELFA | -2374 |
| ELOC | -2008 |
| CCNT1 | -821 |
| SUPT16H | -696 |
| NELFCD | -428 |
| POLR2A | 147 |
| POLR2B | 1638 |
| GTF2F2 | 2060 |
| POLR2D | 4368 |
| ELOA | 4517 |
| POLR2K | 5408 |
| TCEA1 | 5602 |
| CCNK | 9755 |
| CCNT2 | 10381 |
Pausing and recovery of HIV elongation
| 806 | |
|---|---|
| set | Pausing and recovery of HIV elongation |
| setSize | 32 |
| pANOVA | 1.86e-05 |
| s.dist | -0.437 |
| p.adjustANOVA | 0.000314 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| CDK9 | -8934 |
| NELFB | -8842 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| ELOB | -8383 |
| POLR2H | -8250 |
| CTDP1 | -7881 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| SSRP1 | -6970 |
| ELL | -6868 |
| SUPT5H | -5989 |
| NELFE | -5284 |
| SUPT4H1 | -2488 |
| NELFA | -2374 |
| ELOC | -2008 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| CDK9 | -8934 |
| NELFB | -8842 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| ELOB | -8383 |
| POLR2H | -8250 |
| CTDP1 | -7881 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| SSRP1 | -6970 |
| ELL | -6868 |
| SUPT5H | -5989 |
| NELFE | -5284 |
| SUPT4H1 | -2488 |
| NELFA | -2374 |
| ELOC | -2008 |
| CCNT1 | -821 |
| SUPT16H | -696 |
| NELFCD | -428 |
| POLR2A | 147 |
| POLR2B | 1638 |
| GTF2F2 | 2060 |
| POLR2D | 4368 |
| ELOA | 4517 |
| POLR2K | 5408 |
| TCEA1 | 5602 |
| CCNK | 9755 |
| CCNT2 | 10381 |
NF-kB is activated and signals survival
| 699 | |
|---|---|
| set | NF-kB is activated and signals survival |
| setSize | 12 |
| pANOVA | 0.00928 |
| s.dist | -0.434 |
| p.adjustANOVA | 0.0539 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| SQSTM1 | -8420 |
| UBB | -6801 |
| RELA | -6310 |
| NFKBIA | -5834 |
| IRAK1 | -5413 |
| NFKB1 | -1995 |
| IKBKB | -464 |
| UBC | 972 |
| TRAF6 | 5948 |
| NGFR | 9390 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| SQSTM1 | -8420 |
| UBB | -6801 |
| RELA | -6310 |
| NFKBIA | -5834 |
| IRAK1 | -5413 |
| NFKB1 | -1995 |
| IKBKB | -464 |
| UBC | 972 |
| TRAF6 | 5948 |
| NGFR | 9390 |
Inhibition of DNA recombination at telomere
| 531 | |
|---|---|
| set | Inhibition of DNA recombination at telomere |
| setSize | 35 |
| pANOVA | 9.61e-06 |
| s.dist | -0.432 |
| p.adjustANOVA | 0.00018 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| H2AZ1 | -8900 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| ACD | -8254 |
| POLR2H | -8250 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| POLR2C | -7422 |
| H2AJ | -7409 |
| TINF2 | -6560 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| DAXX | -3683 |
| H2BC9 | -2948 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| POLR2F | -8986 |
| H2AZ1 | -8900 |
| POLR2I | -8796 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| ACD | -8254 |
| POLR2H | -8250 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| POLR2C | -7422 |
| H2AJ | -7409 |
| TINF2 | -6560 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| DAXX | -3683 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| POLR2A | 147 |
| H3-3A | 1111 |
| TERF2 | 1365 |
| POLR2B | 1638 |
| H2AC20 | 3617 |
| POLR2D | 4368 |
| POLR2K | 5408 |
| TERF1 | 6253 |
| POT1 | 9092 |
| ATRX | 10921 |
Signaling by ROBO receptors
| 1131 | |
|---|---|
| set | Signaling by ROBO receptors |
| setSize | 202 |
| pANOVA | 1.44e-25 |
| s.dist | -0.426 |
| p.adjustANOVA | 7.54e-24 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| MAGOH | -9296 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| RPS10 | -9297 |
| MAGOH | -9296 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| RPS11 | -9278 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| ROBO3 | -9197 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| PSMB6 | -8886 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| RPL23 | -8734 |
| RPL5 | -8709 |
| RPS15 | -8688 |
| LDB1 | -8678 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| RPL13A | -8497 |
| RPL21 | -8453 |
| RPL11 | -8400 |
| ELOB | -8383 |
| PSMD2 | -8380 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| PSMB7 | -8306 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| PSMD9 | -8273 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| PSMC5 | -8197 |
| PSMB5 | -8188 |
| RPS4X | -8156 |
| NCK2 | -8136 |
| PSMD3 | -8115 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| RPL34 | -7929 |
| PSMC3 | -7569 |
| PFN1 | -7499 |
| RPL13 | -7444 |
| PSMD4 | -7418 |
| RPL9 | -7271 |
| PSMD8 | -7130 |
| PSMB4 | -7001 |
| RPL39L | -6939 |
| EIF4A3 | -6926 |
| UBB | -6801 |
| SEM1 | -6746 |
| RPS3A | -6738 |
| PSMC4 | -6544 |
| RPL26L1 | -6526 |
| RBM8A | -6424 |
| ROBO1 | -6198 |
| NELL2 | -6158 |
| GSPT2 | -6078 |
| RPL28 | -5887 |
| PSMB10 | -5875 |
| PAK4 | -5773 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| ZSWIM8 | -5535 |
| NTN1 | -5489 |
| ABL1 | -5274 |
| CASC3 | -5146 |
| SLIT1 | -5127 |
| PSMD13 | -5048 |
| GPC1 | -5030 |
| RNPS1 | -4925 |
| EVL | -4840 |
| EIF4G1 | -4627 |
| CLASP1 | -4495 |
| PSMB1 | -4370 |
| PSMA7 | -4354 |
| PRKCA | -4088 |
| PSMF1 | -4035 |
| VASP | -3952 |
| PSMB3 | -3936 |
| PAK6 | -3031 |
| CXCR4 | -2793 |
| PFN2 | -2774 |
| ARHGAP39 | -2648 |
| DAG1 | -2080 |
| PSMA2 | -2019 |
| ELOC | -2008 |
| SLIT3 | -1822 |
| RPSA | -1714 |
| RPL22L1 | -1618 |
| PAK3 | -1558 |
| RPS26 | -1506 |
| ABL2 | -1479 |
| PRKACB | -1386 |
| CAP1 | -1153 |
| PRKACA | -1073 |
| UPF3A | -951 |
| MYO9B | -819 |
| PSMC1 | 19 |
| NCK1 | 165 |
| AKAP5 | 818 |
| UBC | 972 |
| PSME3 | 1597 |
| PRKAR2A | 1673 |
| PSMB9 | 1806 |
| ENAH | 1898 |
| SRC | 1930 |
| RBX1 | 1943 |
| PSMB8 | 2230 |
| PSMA5 | 2637 |
| PSMA1 | 3078 |
| PSMD6 | 3171 |
| PSMA8 | 3456 |
| PSMB2 | 3837 |
| PSMD10 | 3948 |
| PSME1 | 4213 |
| MAGOHB | 4286 |
| PSMD7 | 4566 |
| PABPC1 | 4676 |
| LHX4 | 4711 |
| RHOA | 5028 |
| PSMC2 | 5256 |
| MSI1 | 5752 |
| PSMD14 | 5767 |
| CLASP2 | 6304 |
| PSME4 | 7120 |
| PSMD1 | 7192 |
| PAK2 | 7403 |
| SOS2 | 7422 |
| ETF1 | 7750 |
| CDC42 | 8079 |
| RAC1 | 8106 |
| PSMD11 | 8277 |
| PPP3CB | 8455 |
| UPF3B | 8627 |
| RPS27L | 8894 |
| CUL2 | 9352 |
| GSPT1 | 9355 |
| PSMC6 | 9427 |
| NCBP2 | 9598 |
| PAK1 | 9688 |
| PSME2 | 10327 |
| NRP1 | 10365 |
| SRGAP3 | 10582 |
| UPF2 | 10589 |
| PSMA6 | 10593 |
| HOXA2 | 10630 |
| PSMD5 | 10855 |
| RPL3L | 10929 |
| NCBP1 | 11061 |
| SRGAP2 | 11400 |
| SOS1 | 11546 |
| PSMA4 | 11585 |
| USP33 | 11756 |
| SRGAP1 | 12056 |
| PSMA3 | 12436 |
| PSMD12 | 12488 |
| RPS4Y1 | 12763 |
Assembly Of The HIV Virion
| 87 | |
|---|---|
| set | Assembly Of The HIV Virion |
| setSize | 15 |
| pANOVA | 0.00454 |
| s.dist | -0.423 |
| p.adjustANOVA | 0.0329 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| FURIN | -8925 |
| UBA52 | -8911 |
| VPS28 | -8635 |
| VPS37B | -8112 |
| PPIA | -8111 |
| UBB | -6801 |
| MVB12A | -6540 |
| UBAP1 | -2654 |
| MVB12B | -595 |
| UBC | 972 |
| NMT2 | 3152 |
| VPS37C | 4106 |
| TSG101 | 5412 |
| VPS37A | 10275 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| FURIN | -8925 |
| UBA52 | -8911 |
| VPS28 | -8635 |
| VPS37B | -8112 |
| PPIA | -8111 |
| UBB | -6801 |
| MVB12A | -6540 |
| UBAP1 | -2654 |
| MVB12B | -595 |
| UBC | 972 |
| NMT2 | 3152 |
| VPS37C | 4106 |
| TSG101 | 5412 |
| VPS37A | 10275 |
Cytosolic iron-sulfur cluster assembly
| 229 | |
|---|---|
| set | Cytosolic iron-sulfur cluster assembly |
| setSize | 13 |
| pANOVA | 0.00828 |
| s.dist | -0.423 |
| p.adjustANOVA | 0.0503 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| NUBP2 | -8862 |
| POLD1 | -8423 |
| CIAO2B | -7898 |
| CIAO3 | -6342 |
| ERCC2 | -5864 |
| CIAPIN1 | -4917 |
| NUBP1 | -4451 |
| MMS19 | -3845 |
| CIAO1 | -3062 |
| RTEL1 | -1349 |
| ABCB7 | 1161 |
| NDOR1 | 5009 |
| BRIP1 | 10178 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| NUBP2 | -8862 |
| POLD1 | -8423 |
| CIAO2B | -7898 |
| CIAO3 | -6342 |
| ERCC2 | -5864 |
| CIAPIN1 | -4917 |
| NUBP1 | -4451 |
| MMS19 | -3845 |
| CIAO1 | -3062 |
| RTEL1 | -1349 |
| ABCB7 | 1161 |
| NDOR1 | 5009 |
| BRIP1 | 10178 |
RMTs methylate histone arginines
| 898 | |
|---|---|
| set | RMTs methylate histone arginines |
| setSize | 37 |
| pANOVA | 9.21e-06 |
| s.dist | -0.421 |
| p.adjustANOVA | 0.000175 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS2 | -9350.0 |
| H2AZ1 | -8900.0 |
| CDK4 | -8658.0 |
| PRMT1 | -8604.0 |
| H2AZ2 | -7692.0 |
| H2AJ | -7409.0 |
| CARM1 | -7284.0 |
| DNMT3A | -7229.0 |
| PRMT6 | -7098.0 |
| H2AW | -7046.0 |
| PRMT7 | -6947.0 |
| COPRS | -6388.0 |
| WDR5 | -6282.0 |
| H3C15 | -5601.5 |
| ARID1B | -5126.0 |
| SMARCD2 | -5112.0 |
| SMARCA4 | -4869.0 |
| SMARCA2 | -4381.0 |
| SMARCD3 | -3711.0 |
| ACTL6A | -3591.0 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS2 | -9350.0 |
| H2AZ1 | -8900.0 |
| CDK4 | -8658.0 |
| PRMT1 | -8604.0 |
| H2AZ2 | -7692.0 |
| H2AJ | -7409.0 |
| CARM1 | -7284.0 |
| DNMT3A | -7229.0 |
| PRMT6 | -7098.0 |
| H2AW | -7046.0 |
| PRMT7 | -6947.0 |
| COPRS | -6388.0 |
| WDR5 | -6282.0 |
| H3C15 | -5601.5 |
| ARID1B | -5126.0 |
| SMARCD2 | -5112.0 |
| SMARCA4 | -4869.0 |
| SMARCA2 | -4381.0 |
| SMARCD3 | -3711.0 |
| ACTL6A | -3591.0 |
| PRMT5 | -3235.0 |
| SMARCE1 | -3103.0 |
| H2AC6 | -2807.0 |
| SMARCB1 | -2601.0 |
| RBBP7 | -2001.0 |
| H2AC11 | -1660.0 |
| ARID1A | -1473.0 |
| SMARCD1 | -1225.0 |
| WDR77 | -1203.0 |
| SMARCC1 | -856.0 |
| SMARCC2 | -319.0 |
| H2AC20 | 3617.0 |
| ARID2 | 3921.0 |
| CCND1 | 5066.0 |
| PBRM1 | 7026.0 |
| PRMT3 | 10250.0 |
| JAK2 | 12715.0 |
Synthesis of PIPs at the late endosome membrane
| 1173 | |
|---|---|
| set | Synthesis of PIPs at the late endosome membrane |
| setSize | 11 |
| pANOVA | 0.0156 |
| s.dist | 0.421 |
| p.adjustANOVA | 0.0777 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MTM1 | 11918 |
| PIK3C3 | 10937 |
| MTMR9 | 10183 |
| PIK3C2A | 10081 |
| MTMR7 | 8566 |
| FIG4 | 7433 |
| PIKFYVE | 6219 |
| MTMR4 | 4466 |
| MTMR2 | 1850 |
| PIK3R4 | 1840 |
| VAC14 | -3571 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MTM1 | 11918 |
| PIK3C3 | 10937 |
| MTMR9 | 10183 |
| PIK3C2A | 10081 |
| MTMR7 | 8566 |
| FIG4 | 7433 |
| PIKFYVE | 6219 |
| MTMR4 | 4466 |
| MTMR2 | 1850 |
| PIK3R4 | 1840 |
| VAC14 | -3571 |
Packaging Of Telomere Ends
| 803 | |
|---|---|
| set | Packaging Of Telomere Ends |
| setSize | 20 |
| pANOVA | 0.00116 |
| s.dist | -0.42 |
| p.adjustANOVA | 0.0118 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| H2AJ | -7409 |
| TINF2 | -6560 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
| H2AC20 | 3617 |
| TERF1 | 6253 |
| POT1 | 9092 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| H2AJ | -7409 |
| TINF2 | -6560 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
| H2AC20 | 3617 |
| TERF1 | 6253 |
| POT1 | 9092 |
Complex I biogenesis
| 204 | |
|---|---|
| set | Complex I biogenesis |
| setSize | 55 |
| pANOVA | 7.67e-08 |
| s.dist | -0.419 |
| p.adjustANOVA | 1.94e-06 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| NDUFA2 | -9213 |
| NDUFA13 | -9109 |
| NDUFB10 | -8923 |
| NDUFA1 | -8788 |
| NDUFB2 | -8736 |
| NDUFS6 | -8689 |
| NDUFB9 | -8369 |
| NDUFB8 | -8292 |
| NDUFC2 | -8276 |
| NDUFB1 | -8220 |
| NDUFS8 | -8142 |
| NDUFB7 | -8085 |
| NDUFV1 | -8003 |
| NDUFAF3 | -7734 |
| NDUFS7 | -7102 |
| NDUFB11 | -6873 |
| NDUFS3 | -6829 |
| ECSIT | -6822 |
| NDUFS5 | -6800 |
| NDUFB4 | -6623 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| NDUFA2 | -9213 |
| NDUFA13 | -9109 |
| NDUFB10 | -8923 |
| NDUFA1 | -8788 |
| NDUFB2 | -8736 |
| NDUFS6 | -8689 |
| NDUFB9 | -8369 |
| NDUFB8 | -8292 |
| NDUFC2 | -8276 |
| NDUFB1 | -8220 |
| NDUFS8 | -8142 |
| NDUFB7 | -8085 |
| NDUFV1 | -8003 |
| NDUFAF3 | -7734 |
| NDUFS7 | -7102 |
| NDUFB11 | -6873 |
| NDUFS3 | -6829 |
| ECSIT | -6822 |
| NDUFS5 | -6800 |
| NDUFB4 | -6623 |
| NDUFA6 | -6600 |
| NDUFA3 | -6596 |
| NDUFA7 | -6554 |
| NDUFAB1 | -6290 |
| MT-ND3 | -6232 |
| ACAD9 | -6210 |
| NDUFA11 | -6208 |
| NDUFC1 | -5268 |
| NDUFS2 | -5168 |
| NDUFAF4 | -4813 |
| NDUFB3 | -4489 |
| NDUFA12 | -3458 |
| MT-ND1 | -3379 |
| NDUFB6 | -2836 |
| NDUFA10 | -2249 |
| NDUFAF2 | -1425 |
| MT-ND2 | -1038 |
| MT-ND5 | -825 |
| NDUFAF5 | 450 |
| NDUFA8 | 465 |
| NDUFAF7 | 1679 |
| NDUFAF1 | 2477 |
| NDUFS4 | 2482 |
| NDUFV3 | 2967 |
| NDUFS1 | 3094 |
| MT-ND6 | 3579 |
| NDUFV2 | 4553 |
| NDUFAF6 | 5172 |
| TMEM126B | 5267 |
| NDUFB5 | 6507 |
| NUBPL | 6600 |
| TIMMDC1 | 6956 |
| MT-ND4 | 7163 |
| NDUFA9 | 9503 |
| NDUFA5 | 9749 |
HSF1-dependent transactivation
| 490 | |
|---|---|
| set | HSF1-dependent transactivation |
| setSize | 29 |
| pANOVA | 0.000108 |
| s.dist | -0.415 |
| p.adjustANOVA | 0.0015 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| DNAJB1 | -8595 |
| SERPINH1 | -8066 |
| MLST8 | -7481 |
| AKT1S1 | -7256 |
| DEDD2 | -6963 |
| UBB | -6801 |
| FKBP4 | -6645 |
| MTOR | -5657 |
| HSPA2 | -5627 |
| CAMK2G | -5624 |
| HSPA1A | -5222 |
| CREBBP | -5185 |
| HSF1 | -5065 |
| HSPA1L | -4338 |
| HSP90AB1 | -3612 |
| RLN1 | -3385 |
| TNFRSF21 | -3225 |
| CAMK2D | -2872 |
| DNAJB6 | -2641 |
| HSPA1B | -1882 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| DNAJB1 | -8595 |
| SERPINH1 | -8066 |
| MLST8 | -7481 |
| AKT1S1 | -7256 |
| DEDD2 | -6963 |
| UBB | -6801 |
| FKBP4 | -6645 |
| MTOR | -5657 |
| HSPA2 | -5627 |
| CAMK2G | -5624 |
| HSPA1A | -5222 |
| CREBBP | -5185 |
| HSF1 | -5065 |
| HSPA1L | -4338 |
| HSP90AB1 | -3612 |
| RLN1 | -3385 |
| TNFRSF21 | -3225 |
| CAMK2D | -2872 |
| DNAJB6 | -2641 |
| HSPA1B | -1882 |
| MRPL18 | -1770 |
| RPTOR | -1703 |
| HSPA6 | -1136 |
| HSPA8 | -190 |
| EP300 | 2665 |
| HSBP1 | 4811 |
| HSPH1 | 5385 |
| HSP90AA1 | 6784 |
| PTGES3 | 7569 |
Glycogen storage diseases
| 462 | |
|---|---|
| set | Glycogen storage diseases |
| setSize | 13 |
| pANOVA | 0.0098 |
| s.dist | -0.414 |
| p.adjustANOVA | 0.0555 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| NHLRC1 | -7424 |
| UBB | -6801 |
| GAA | -3800 |
| SLC37A4 | -3662 |
| GYG1 | -2512 |
| GBE1 | -1782 |
| G6PC3 | -781 |
| GYS1 | 506 |
| UBC | 972 |
| G6PC | 2162 |
| EPM2A | 3984 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| NHLRC1 | -7424 |
| UBB | -6801 |
| GAA | -3800 |
| SLC37A4 | -3662 |
| GYG1 | -2512 |
| GBE1 | -1782 |
| G6PC3 | -781 |
| GYS1 | 506 |
| UBC | 972 |
| G6PC | 2162 |
| EPM2A | 3984 |
Cleavage of the damaged purine
| 193 | |
|---|---|
| set | Cleavage of the damaged purine |
| setSize | 24 |
| pANOVA | 0.000457 |
| s.dist | -0.413 |
| p.adjustANOVA | 0.00529 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| H2AJ | -7409 |
| MPG | -6849 |
| TINF2 | -6560 |
| MUTYH | -5894 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| H2AJ | -7409 |
| MPG | -6849 |
| TINF2 | -6560 |
| MUTYH | -5894 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
| H2AC20 | 3617 |
| NEIL3 | 4420 |
| TERF1 | 6253 |
| POT1 | 9092 |
Depurination
| 277 | |
|---|---|
| set | Depurination |
| setSize | 24 |
| pANOVA | 0.000457 |
| s.dist | -0.413 |
| p.adjustANOVA | 0.00529 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| H2AJ | -7409 |
| MPG | -6849 |
| TINF2 | -6560 |
| MUTYH | -5894 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| H2AJ | -7409 |
| MPG | -6849 |
| TINF2 | -6560 |
| MUTYH | -5894 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
| H2AC20 | 3617 |
| NEIL3 | 4420 |
| TERF1 | 6253 |
| POT1 | 9092 |
Recognition and association of DNA glycosylase with site containing an affected purine
| 939 | |
|---|---|
| set | Recognition and association of DNA glycosylase with site containing an affected purine |
| setSize | 24 |
| pANOVA | 0.000457 |
| s.dist | -0.413 |
| p.adjustANOVA | 0.00529 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| H2AJ | -7409 |
| MPG | -6849 |
| TINF2 | -6560 |
| MUTYH | -5894 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| H2AJ | -7409 |
| MPG | -6849 |
| TINF2 | -6560 |
| MUTYH | -5894 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
| H2AC20 | 3617 |
| NEIL3 | 4420 |
| TERF1 | 6253 |
| POT1 | 9092 |
Translation
| 1269 | |
|---|---|
| set | Translation |
| setSize | 295 |
| pANOVA | 2.65e-34 |
| s.dist | -0.413 |
| p.adjustANOVA | 2.78e-32 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| MRPL54 | -9340 |
| MRPS34 | -9339 |
| EEF1G | -9328 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| MRPL43 | -9298 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| EEF1B2 | -9281 |
| RPS11 | -9278 |
| MRPL24 | -9275 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPL37 | -9359 |
| RPLP2 | -9351 |
| RPS2 | -9350 |
| RPS17 | -9343 |
| RPS29 | -9341 |
| MRPL54 | -9340 |
| MRPS34 | -9339 |
| EEF1G | -9328 |
| RPL27 | -9307 |
| RPS12 | -9306 |
| RPS21 | -9303 |
| MRPL43 | -9298 |
| RPS10 | -9297 |
| RPLP1 | -9289 |
| RPS27A | -9287 |
| RPS3 | -9286 |
| RPL8 | -9282 |
| EEF1B2 | -9281 |
| RPS11 | -9278 |
| MRPL24 | -9275 |
| TRMT112 | -9274 |
| RPL29 | -9273 |
| RPL38 | -9271 |
| RPL31 | -9267 |
| RPS27 | -9262 |
| RPL36 | -9257 |
| RPL3 | -9248 |
| EIF3F | -9241 |
| RPL7A | -9239 |
| RPL37A | -9238 |
| RPL14 | -9235 |
| RPL10 | -9234 |
| RPS16 | -9230 |
| RPS28 | -9222 |
| FAU | -9221 |
| RPS15A | -9219 |
| RPLP0 | -9208 |
| RPL30 | -9204 |
| RPL27A | -9202 |
| RPS5 | -9195 |
| RPL18A | -9185 |
| RPL41 | -9173 |
| RPL18 | -9172 |
| EEF1D | -9170 |
| EEF2 | -9164 |
| MRPL34 | -9149 |
| EIF3G | -9129 |
| EIF3L | -9116 |
| MRPS7 | -9105 |
| RPS25 | -9056 |
| RPL35A | -9033 |
| RPS23 | -9032 |
| RPL39 | -9027 |
| RPL15 | -9021 |
| RPL32 | -9009 |
| RPL7 | -8993 |
| EIF3C | -8987 |
| RPL12 | -8985 |
| RPL19 | -8978 |
| RPL17 | -8959 |
| RPL36A | -8957 |
| RPS6 | -8956 |
| RPS14 | -8942 |
| RPL26 | -8932 |
| RPS13 | -8921 |
| MRPS12 | -8913 |
| UBA52 | -8911 |
| RPS19 | -8909 |
| MRPL12 | -8895 |
| MRPS26 | -8846 |
| MRPS24 | -8845 |
| RPS7 | -8836 |
| RPS18 | -8815 |
| SEC61B | -8770 |
| MRPL28 | -8761 |
| TUFM | -8744 |
| EIF4H | -8739 |
| RPL23 | -8734 |
| AURKAIP1 | -8713 |
| RPL5 | -8709 |
| EEF1A1 | -8699 |
| RPS15 | -8688 |
| MRPL11 | -8607 |
| RPL36AL | -8577 |
| RPL22 | -8573 |
| SARS2 | -8535 |
| RPL13A | -8497 |
| DDOST | -8473 |
| RPL21 | -8453 |
| CHCHD1 | -8411 |
| RPL11 | -8400 |
| EIF3I | -8392 |
| QARS1 | -8378 |
| MRPL53 | -8374 |
| MRPS21 | -8373 |
| MRPL23 | -8360 |
| RPS9 | -8346 |
| RPL24 | -8320 |
| RPS8 | -8300 |
| RPL4 | -8296 |
| MRPS2 | -8271 |
| FARSA | -8264 |
| RPL35 | -8257 |
| RPS20 | -8253 |
| RPS4X | -8156 |
| MRPL14 | -8114 |
| RPL23A | -8104 |
| RPL10A | -8026 |
| EIF3D | -8004 |
| GADD45GIP1 | -7982 |
| RPL34 | -7929 |
| EIF3B | -7853 |
| EIF4B | -7834 |
| MRPL38 | -7787 |
| MRPL58 | -7637 |
| LARS2 | -7590 |
| RPL13 | -7444 |
| MRPL55 | -7343 |
| MRPL51 | -7338 |
| MRPL49 | -7324 |
| EEF1A1P5 | -7306 |
| RPL9 | -7271 |
| MRPS6 | -7144 |
| EIF3K | -7122 |
| SSR4 | -7121 |
| APEH | -7112 |
| MRPS15 | -7058 |
| EIF2B2 | -6988 |
| RPL39L | -6939 |
| RPS3A | -6738 |
| SARS1 | -6720 |
| SSR2 | -6581 |
| RPL26L1 | -6526 |
| MRPL9 | -6497 |
| MRPL57 | -6464 |
| MRPL36 | -6416 |
| EIF3H | -6227 |
| MRPL37 | -6166 |
| GSPT2 | -6078 |
| RPL28 | -5887 |
| MT-TV | -5819 |
| MRPL40 | -5780 |
| TSFM | -5709 |
| RPL6 | -5674 |
| RPS24 | -5639 |
| MRPL17 | -5578 |
| EIF2B4 | -5527 |
| MRPL41 | -5502 |
| MRPL45 | -5466 |
| MRPL27 | -5431 |
| MRPS16 | -5371 |
| MRPL52 | -5331 |
| MRPS33 | -5090 |
| AARS2 | -4949 |
| MRPS23 | -4820 |
| EIF4G1 | -4627 |
| FARS2 | -4544 |
| MRPL21 | -4329 |
| SPCS1 | -4245 |
| MRPL46 | -4059 |
| EIF4EBP1 | -4048 |
| DAP3 | -4000 |
| MRPL15 | -3999 |
| MRPL48 | -3963 |
| MRPS28 | -3944 |
| MRPL20 | -3929 |
| MRPL33 | -3795 |
| RPN1 | -3732 |
| OXA1L | -3336 |
| MARS2 | -3204 |
| MRPL2 | -3011 |
| EIF2B5 | -2814 |
| N6AMT1 | -2783 |
| CARS2 | -2667 |
| SRPRA | -2588 |
| AARS1 | -2560 |
| NARS2 | -2372 |
| MRPL3 | -2323 |
| MRPS11 | -2021 |
| VARS2 | -1930 |
| SEC11A | -1921 |
| MRPS18A | -1821 |
| MRPL18 | -1770 |
| VARS1 | -1755 |
| MRPS9 | -1753 |
| RPSA | -1714 |
| MRPS30 | -1700 |
| RPL22L1 | -1618 |
| EARS2 | -1612 |
| RPS26 | -1506 |
| HARS1 | -1418 |
| SRP68 | -1340 |
| MRPL16 | -1220 |
| MRPS25 | -1098 |
| SEC61A1 | -1055 |
| EIF4A1 | -807 |
| MRPL30 | -797 |
| MRPS17 | -505 |
| ERAL1 | -373 |
| EEF1E1 | -329 |
| MTFMT | -219 |
| MRPS36 | -145 |
| MRPL4 | -92 |
| IARS2 | -78 |
| GFM1 | -55 |
| PARS2 | 46 |
| MT-RNR1 | 149 |
| YARS1 | 247 |
| SRP14 | 419 |
| MRPL10 | 424 |
| MRPS18B | 609 |
| MT-RNR2 | 677 |
| YARS2 | 735 |
| MRPL22 | 776 |
| MRPS27 | 1043 |
| EEF1A2 | 1186 |
| RPN2 | 1383 |
| EIF3E | 1417 |
| IARS1 | 1693 |
| SRPRB | 2167 |
| EIF1AX | 2485 |
| MRPS5 | 2527 |
| MRPL32 | 2842 |
| CARS1 | 2916 |
| EIF4A2 | 3187 |
| MRPL35 | 3271 |
| MRPS18C | 3355 |
| MRPL50 | 3474 |
| HARS2 | 3528 |
| AIMP2 | 3530 |
| EIF3A | 3853 |
| PPA1 | 3971 |
| SRP9 | 4053 |
| DARS2 | 4125 |
| SSR1 | 4321 |
| MRPL44 | 4611 |
| PABPC1 | 4676 |
| SRP72 | 4960 |
| EIF2S3 | 5397 |
| MARS1 | 5416 |
| EIF2B1 | 5427 |
| EIF2B3 | 5429 |
| MRPS14 | 5512 |
| EIF3M | 5545 |
| EPRS1 | 5581 |
| KARS1 | 5618 |
| PTCD3 | 5651 |
| EIF5 | 6148 |
| SSR3 | 6159 |
| EIF2S1 | 6183 |
| WARS2 | 6195 |
| SPCS2 | 6229 |
| MRPS22 | 6337 |
| SEC61G | 6364 |
| SEC61A2 | 6567 |
| PPA2 | 6722 |
| TARS1 | 6955 |
| MRPS31 | 7153 |
| NARS1 | 7201 |
| MRPL19 | 7255 |
| SEC11C | 7454 |
| MRRF | 7652 |
| ETF1 | 7750 |
| MRPL47 | 8014 |
| MRPL13 | 8300 |
| LARS1 | 8416 |
| MRPS10 | 8421 |
| GFM2 | 8453 |
| MRPL39 | 8523 |
| FARSB | 8782 |
| RPS27L | 8894 |
| EIF2S2 | 8941 |
| TRAM1 | 9094 |
| EIF3J | 9265 |
| EIF4E | 9328 |
| MRPS35 | 9329 |
| MTIF2 | 9342 |
| GSPT1 | 9355 |
| MRPL1 | 9363 |
| MTRF1L | 9883 |
| EIF5B | 10235 |
| SPCS3 | 10349 |
| GARS1 | 10414 |
| DARS1 | 10424 |
| AIMP1 | 10500 |
| RARS2 | 10689 |
| MTIF3 | 10838 |
| RPL3L | 10929 |
| TARS2 | 11089 |
| RARS1 | 11354 |
| SRP19 | 11751 |
| SRP54 | 12051 |
| MRPL42 | 12516 |
| WARS1 | 12617 |
| RPS4Y1 | 12763 |
Mitochondrial translation elongation
| 671 | |
|---|---|
| set | Mitochondrial translation elongation |
| setSize | 91 |
| pANOVA | 1.6e-11 |
| s.dist | -0.409 |
| p.adjustANOVA | 5.32e-10 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MRPL54 | -9340 |
| MRPS34 | -9339 |
| MRPL43 | -9298 |
| MRPL24 | -9275 |
| MRPL34 | -9149 |
| MRPS7 | -9105 |
| MRPS12 | -8913 |
| MRPL12 | -8895 |
| MRPS26 | -8846 |
| MRPS24 | -8845 |
| MRPL28 | -8761 |
| TUFM | -8744 |
| AURKAIP1 | -8713 |
| MRPL11 | -8607 |
| CHCHD1 | -8411 |
| MRPL53 | -8374 |
| MRPS21 | -8373 |
| MRPL23 | -8360 |
| MRPS2 | -8271 |
| MRPL14 | -8114 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MRPL54 | -9340 |
| MRPS34 | -9339 |
| MRPL43 | -9298 |
| MRPL24 | -9275 |
| MRPL34 | -9149 |
| MRPS7 | -9105 |
| MRPS12 | -8913 |
| MRPL12 | -8895 |
| MRPS26 | -8846 |
| MRPS24 | -8845 |
| MRPL28 | -8761 |
| TUFM | -8744 |
| AURKAIP1 | -8713 |
| MRPL11 | -8607 |
| CHCHD1 | -8411 |
| MRPL53 | -8374 |
| MRPS21 | -8373 |
| MRPL23 | -8360 |
| MRPS2 | -8271 |
| MRPL14 | -8114 |
| GADD45GIP1 | -7982 |
| MRPL38 | -7787 |
| MRPL58 | -7637 |
| MRPL55 | -7343 |
| MRPL51 | -7338 |
| MRPL49 | -7324 |
| MRPS6 | -7144 |
| MRPS15 | -7058 |
| MRPL9 | -6497 |
| MRPL57 | -6464 |
| MRPL36 | -6416 |
| MRPL37 | -6166 |
| MT-TV | -5819 |
| MRPL40 | -5780 |
| TSFM | -5709 |
| MRPL17 | -5578 |
| MRPL41 | -5502 |
| MRPL45 | -5466 |
| MRPL27 | -5431 |
| MRPS16 | -5371 |
| MRPL52 | -5331 |
| MRPS33 | -5090 |
| MRPS23 | -4820 |
| MRPL21 | -4329 |
| MRPL46 | -4059 |
| DAP3 | -4000 |
| MRPL15 | -3999 |
| MRPL48 | -3963 |
| MRPS28 | -3944 |
| MRPL20 | -3929 |
| MRPL33 | -3795 |
| OXA1L | -3336 |
| MRPL2 | -3011 |
| MRPL3 | -2323 |
| MRPS11 | -2021 |
| MRPS18A | -1821 |
| MRPL18 | -1770 |
| MRPS9 | -1753 |
| MRPS30 | -1700 |
| MRPL16 | -1220 |
| MRPS25 | -1098 |
| MRPL30 | -797 |
| MRPS17 | -505 |
| ERAL1 | -373 |
| MRPS36 | -145 |
| MRPL4 | -92 |
| GFM1 | -55 |
| MT-RNR1 | 149 |
| MRPL10 | 424 |
| MRPS18B | 609 |
| MT-RNR2 | 677 |
| MRPL22 | 776 |
| MRPS27 | 1043 |
| MRPS5 | 2527 |
| MRPL32 | 2842 |
| MRPL35 | 3271 |
| MRPS18C | 3355 |
| MRPL50 | 3474 |
| MRPL44 | 4611 |
| MRPS14 | 5512 |
| PTCD3 | 5651 |
| MRPS22 | 6337 |
| MRPS31 | 7153 |
| MRPL19 | 7255 |
| MRPL47 | 8014 |
| MRPL13 | 8300 |
| MRPS10 | 8421 |
| MRPL39 | 8523 |
| MRPS35 | 9329 |
| MRPL1 | 9363 |
| MRPL42 | 12516 |
Glycogen synthesis
| 463 | |
|---|---|
| set | Glycogen synthesis |
| setSize | 13 |
| pANOVA | 0.0109 |
| s.dist | -0.408 |
| p.adjustANOVA | 0.0605 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| PGM1 | -7673 |
| NHLRC1 | -7424 |
| UBB | -6801 |
| PGM2 | -4711 |
| GYG1 | -2512 |
| PGM2L1 | -2407 |
| GBE1 | -1782 |
| GYS1 | 506 |
| UBC | 972 |
| EPM2A | 3984 |
| UGP2 | 9592 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| PGM1 | -7673 |
| NHLRC1 | -7424 |
| UBB | -6801 |
| PGM2 | -4711 |
| GYG1 | -2512 |
| PGM2L1 | -2407 |
| GBE1 | -1782 |
| GYS1 | 506 |
| UBC | 972 |
| EPM2A | 3984 |
| UGP2 | 9592 |
AKT phosphorylates targets in the nucleus
| 9 | |
|---|---|
| set | AKT phosphorylates targets in the nucleus |
| setSize | 10 |
| pANOVA | 0.0259 |
| s.dist | -0.407 |
| p.adjustANOVA | 0.107 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| AKT2 | -8795 |
| AKT1 | -8208 |
| FOXO4 | -8042 |
| FOXO1 | -5922 |
| RPS6KB2 | -5805 |
| FOXO6 | -4190 |
| FOXO3 | -3539 |
| AKT3 | 951 |
| CREB1 | 7185 |
| NR4A1 | 8412 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| AKT2 | -8795 |
| AKT1 | -8208 |
| FOXO4 | -8042 |
| FOXO1 | -5922 |
| RPS6KB2 | -5805 |
| FOXO6 | -4190 |
| FOXO3 | -3539 |
| AKT3 | 951 |
| CREB1 | 7185 |
| NR4A1 | 8412 |
Interleukin-2 signaling
| 562 | |
|---|---|
| set | Interleukin-2 signaling |
| setSize | 11 |
| pANOVA | 0.0196 |
| s.dist | -0.406 |
| p.adjustANOVA | 0.0904 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| IL2RB | -9206 |
| JAK1 | -7689 |
| STAT5B | -7576 |
| LCK | -7236 |
| PTK2B | -6247 |
| JAK3 | -4513 |
| IL2RG | -2578 |
| STAT5A | -1477 |
| SYK | -59 |
| SHC1 | 7453 |
| IL2RA | 8409 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| IL2RB | -9206 |
| JAK1 | -7689 |
| STAT5B | -7576 |
| LCK | -7236 |
| PTK2B | -6247 |
| JAK3 | -4513 |
| IL2RG | -2578 |
| STAT5A | -1477 |
| SYK | -59 |
| SHC1 | 7453 |
| IL2RA | 8409 |
Regulation of TP53 Activity through Acetylation
| 972 | |
|---|---|
| set | Regulation of TP53 Activity through Acetylation |
| setSize | 29 |
| pANOVA | 0.000153 |
| s.dist | -0.406 |
| p.adjustANOVA | 0.00207 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| PIN1 | -9150 |
| AKT2 | -8795 |
| CHD3 | -8299 |
| AKT1 | -8208 |
| MBD3 | -8181 |
| PIP4K2B | -8173 |
| BRPF1 | -8080 |
| BRD1 | -7142 |
| HDAC1 | -7004 |
| MTA2 | -5860 |
| BRPF3 | -5829 |
| PIP4K2A | -5606 |
| ING5 | -5443 |
| KAT6A | -5173 |
| GATAD2A | -4830 |
| CHD4 | -4769 |
| TP53 | -2156 |
| RBBP7 | -2001 |
| PIP4K2C | -1644 |
| MEAF6 | -301 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| PIN1 | -9150 |
| AKT2 | -8795 |
| CHD3 | -8299 |
| AKT1 | -8208 |
| MBD3 | -8181 |
| PIP4K2B | -8173 |
| BRPF1 | -8080 |
| BRD1 | -7142 |
| HDAC1 | -7004 |
| MTA2 | -5860 |
| BRPF3 | -5829 |
| PIP4K2A | -5606 |
| ING5 | -5443 |
| KAT6A | -5173 |
| GATAD2A | -4830 |
| CHD4 | -4769 |
| TP53 | -2156 |
| RBBP7 | -2001 |
| PIP4K2C | -1644 |
| MEAF6 | -301 |
| ING2 | 315 |
| HDAC2 | 439 |
| AKT3 | 951 |
| RBBP4 | 1097 |
| EP300 | 2665 |
| GATAD2B | 3024 |
| MAP2K6 | 6083 |
| BRD7 | 9344 |
| PML | 11946 |
tRNA processing in the mitochondrion
| 1362 | |
|---|---|
| set | tRNA processing in the mitochondrion |
| setSize | 32 |
| pANOVA | 7.31e-05 |
| s.dist | -0.405 |
| p.adjustANOVA | 0.00107 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MT-TN | -9309 |
| MT-TS1 | -9258 |
| MT-ATP8 | -8945 |
| MT-TC | -8515 |
| MT-TA | -8343 |
| MT-TP | -7808 |
| MT-CO3 | -7585 |
| MT-ATP6 | -6906 |
| HSD17B10 | -6363 |
| MT-ND3 | -6232 |
| ELAC2 | -5953 |
| MT-TV | -5819 |
| MT-ND4L | -5454 |
| MT-CO2 | -4684 |
| MT-TY | -4561 |
| MT-TF | -4357 |
| MT-TM | -3832 |
| MT-TL2 | -3777 |
| MT-ND1 | -3379 |
| MT-CYB | -1416 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MT-TN | -9309 |
| MT-TS1 | -9258 |
| MT-ATP8 | -8945 |
| MT-TC | -8515 |
| MT-TA | -8343 |
| MT-TP | -7808 |
| MT-CO3 | -7585 |
| MT-ATP6 | -6906 |
| HSD17B10 | -6363 |
| MT-ND3 | -6232 |
| ELAC2 | -5953 |
| MT-TV | -5819 |
| MT-ND4L | -5454 |
| MT-CO2 | -4684 |
| MT-TY | -4561 |
| MT-TF | -4357 |
| MT-TM | -3832 |
| MT-TL2 | -3777 |
| MT-ND1 | -3379 |
| MT-CYB | -1416 |
| MT-ND2 | -1038 |
| MT-ND5 | -825 |
| MT-RNR1 | 149 |
| MT-CO1 | 171 |
| MT-RNR2 | 677 |
| MT-TL1 | 1060 |
| MT-TE | 2401 |
| PRORP | 3101 |
| MT-ND6 | 3579 |
| TRMT10C | 6586 |
| MT-ND4 | 7163 |
| TRNT1 | 10757 |
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
| 1007 | |
|---|---|
| set | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| setSize | 124 |
| pANOVA | 2.05e-14 |
| s.dist | -0.397 |
| p.adjustANOVA | 7.18e-13 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| NDUFA2 | -9213 |
| TACO1 | -9161 |
| ATP5MG | -9147 |
| ATP5ME | -9120 |
| NDUFA13 | -9109 |
| UQCR10 | -9090 |
| UQCR11 | -9084 |
| MT-ATP8 | -8945 |
| NDUFB10 | -8923 |
| ATP5MF | -8794 |
| NDUFA1 | -8788 |
| UQCRH | -8763 |
| ATP5F1D | -8754 |
| NDUFB2 | -8736 |
| NDUFS6 | -8689 |
| COX6A1 | -8596 |
| COX7C | -8454 |
| NDUFB9 | -8369 |
| NDUFB8 | -8292 |
| NDUFC2 | -8276 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| NDUFA2 | -9213 |
| TACO1 | -9161 |
| ATP5MG | -9147 |
| ATP5ME | -9120 |
| NDUFA13 | -9109 |
| UQCR10 | -9090 |
| UQCR11 | -9084 |
| MT-ATP8 | -8945 |
| NDUFB10 | -8923 |
| ATP5MF | -8794 |
| NDUFA1 | -8788 |
| UQCRH | -8763 |
| ATP5F1D | -8754 |
| NDUFB2 | -8736 |
| NDUFS6 | -8689 |
| COX6A1 | -8596 |
| COX7C | -8454 |
| NDUFB9 | -8369 |
| NDUFB8 | -8292 |
| NDUFC2 | -8276 |
| SDHC | -8241 |
| NDUFB1 | -8220 |
| ATP5MC2 | -8170 |
| NDUFS8 | -8142 |
| NDUFB7 | -8085 |
| COX5B | -8053 |
| COX14 | -8038 |
| NDUFV1 | -8003 |
| COX8A | -7749 |
| NDUFAF3 | -7734 |
| MT-CO3 | -7585 |
| CYC1 | -7555 |
| UQCRQ | -7177 |
| NDUFS7 | -7102 |
| NDUFA4 | -7099 |
| COX4I1 | -7090 |
| ATP5F1A | -7067 |
| ATP5F1E | -6990 |
| MT-ATP6 | -6906 |
| NDUFB11 | -6873 |
| ATP5MC3 | -6871 |
| NDUFS3 | -6829 |
| ECSIT | -6822 |
| NDUFS5 | -6800 |
| NDUFB4 | -6623 |
| COX5A | -6619 |
| NDUFA6 | -6600 |
| NDUFA3 | -6596 |
| COX6C | -6567 |
| NDUFA7 | -6554 |
| ATP5PB | -6434 |
| NDUFAB1 | -6290 |
| MT-ND3 | -6232 |
| ACAD9 | -6210 |
| NDUFA11 | -6208 |
| COX6B1 | -6135 |
| COX7B | -5599 |
| ATP5PF | -5589 |
| ETFB | -5380 |
| NDUFC1 | -5268 |
| NDUFS2 | -5168 |
| NDUFAF4 | -4813 |
| UQCRB | -4788 |
| MT-CO2 | -4684 |
| TRAP1 | -4527 |
| NDUFB3 | -4489 |
| UQCRC1 | -3998 |
| NDUFA12 | -3458 |
| COQ10A | -3408 |
| MT-ND1 | -3379 |
| UCP3 | -3172 |
| ATP5PO | -3155 |
| SDHA | -2974 |
| NDUFB6 | -2836 |
| ATP5MC1 | -2555 |
| SURF1 | -2478 |
| UCP2 | -2279 |
| NDUFA10 | -2249 |
| ATP5F1B | -1757 |
| NDUFAF2 | -1425 |
| MT-CYB | -1416 |
| COX7A2L | -1101 |
| MT-ND2 | -1038 |
| COX11 | -841 |
| MT-ND5 | -825 |
| SDHB | -49 |
| MT-CO1 | 171 |
| SLC25A14 | 362 |
| NDUFAF5 | 450 |
| NDUFA8 | 465 |
| LRPPRC | 1515 |
| UQCRFS1 | 1558 |
| SCO1 | 1628 |
| NDUFAF7 | 1679 |
| UQCRC2 | 1986 |
| ATP5PD | 2098 |
| NDUFAF1 | 2477 |
| NDUFS4 | 2482 |
| NDUFV3 | 2967 |
| NDUFS1 | 3094 |
| MT-ND6 | 3579 |
| PM20D1 | 3897 |
| NDUFV2 | 4553 |
| NDUFAF6 | 5172 |
| TMEM126B | 5267 |
| ATP5F1C | 5853 |
| SDHD | 6067 |
| CYCS | 6358 |
| COX19 | 6490 |
| NDUFB5 | 6507 |
| COQ10B | 6571 |
| NUBPL | 6600 |
| TIMMDC1 | 6956 |
| COX20 | 7007 |
| MT-ND4 | 7163 |
| SCO2 | 7253 |
| COX16 | 8000 |
| SLC25A27 | 9315 |
| ETFA | 9420 |
| NDUFA9 | 9503 |
| ETFDH | 9566 |
| NDUFA5 | 9749 |
| DMAC2L | 11208 |
| COX18 | 11257 |
Trafficking of GluR2-containing AMPA receptors
| 1249 | |
|---|---|
| set | Trafficking of GluR2-containing AMPA receptors |
| setSize | 12 |
| pANOVA | 0.0199 |
| s.dist | -0.388 |
| p.adjustANOVA | 0.0913 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| AP2M1 | -8551 |
| AP2A2 | -7462 |
| AP2S1 | -5881 |
| PICK1 | -4926 |
| PRKCA | -4088 |
| AP2B1 | -3883 |
| TSPAN7 | -2444 |
| NSF | -905 |
| PRKCB | -859 |
| AP2A1 | 323 |
| GRIP1 | 452 |
| GRIA4 | 7157 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| AP2M1 | -8551 |
| AP2A2 | -7462 |
| AP2S1 | -5881 |
| PICK1 | -4926 |
| PRKCA | -4088 |
| AP2B1 | -3883 |
| TSPAN7 | -2444 |
| NSF | -905 |
| PRKCB | -859 |
| AP2A1 | 323 |
| GRIP1 | 452 |
| GRIA4 | 7157 |
Base-Excision Repair, AP Site Formation
| 103 | |
|---|---|
| set | Base-Excision Repair, AP Site Formation |
| setSize | 31 |
| pANOVA | 0.000194 |
| s.dist | -0.387 |
| p.adjustANOVA | 0.00252 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| NEIL1 | -7681 |
| H2AJ | -7409 |
| UNG | -6905 |
| MPG | -6849 |
| TINF2 | -6560 |
| MUTYH | -5894 |
| NTHL1 | -5718 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| NEIL2 | -3484 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| NEIL1 | -7681 |
| H2AJ | -7409 |
| UNG | -6905 |
| MPG | -6849 |
| TINF2 | -6560 |
| MUTYH | -5894 |
| NTHL1 | -5718 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| NEIL2 | -3484 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
| MBD4 | 3242 |
| SMUG1 | 3331 |
| H2AC20 | 3617 |
| NEIL3 | 4420 |
| TERF1 | 6253 |
| TDG | 6297 |
| POT1 | 9092 |
Respiratory electron transport
| 1006 | |
|---|---|
| set | Respiratory electron transport |
| setSize | 101 |
| pANOVA | 1.86e-11 |
| s.dist | -0.387 |
| p.adjustANOVA | 6.06e-10 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| NDUFA2 | -9213 |
| TACO1 | -9161 |
| NDUFA13 | -9109 |
| UQCR10 | -9090 |
| UQCR11 | -9084 |
| NDUFB10 | -8923 |
| NDUFA1 | -8788 |
| UQCRH | -8763 |
| NDUFB2 | -8736 |
| NDUFS6 | -8689 |
| COX6A1 | -8596 |
| COX7C | -8454 |
| NDUFB9 | -8369 |
| NDUFB8 | -8292 |
| NDUFC2 | -8276 |
| SDHC | -8241 |
| NDUFB1 | -8220 |
| NDUFS8 | -8142 |
| NDUFB7 | -8085 |
| COX5B | -8053 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| NDUFA2 | -9213 |
| TACO1 | -9161 |
| NDUFA13 | -9109 |
| UQCR10 | -9090 |
| UQCR11 | -9084 |
| NDUFB10 | -8923 |
| NDUFA1 | -8788 |
| UQCRH | -8763 |
| NDUFB2 | -8736 |
| NDUFS6 | -8689 |
| COX6A1 | -8596 |
| COX7C | -8454 |
| NDUFB9 | -8369 |
| NDUFB8 | -8292 |
| NDUFC2 | -8276 |
| SDHC | -8241 |
| NDUFB1 | -8220 |
| NDUFS8 | -8142 |
| NDUFB7 | -8085 |
| COX5B | -8053 |
| COX14 | -8038 |
| NDUFV1 | -8003 |
| COX8A | -7749 |
| NDUFAF3 | -7734 |
| MT-CO3 | -7585 |
| CYC1 | -7555 |
| UQCRQ | -7177 |
| NDUFS7 | -7102 |
| NDUFA4 | -7099 |
| COX4I1 | -7090 |
| NDUFB11 | -6873 |
| NDUFS3 | -6829 |
| ECSIT | -6822 |
| NDUFS5 | -6800 |
| NDUFB4 | -6623 |
| COX5A | -6619 |
| NDUFA6 | -6600 |
| NDUFA3 | -6596 |
| COX6C | -6567 |
| NDUFA7 | -6554 |
| NDUFAB1 | -6290 |
| MT-ND3 | -6232 |
| ACAD9 | -6210 |
| NDUFA11 | -6208 |
| COX6B1 | -6135 |
| COX7B | -5599 |
| ETFB | -5380 |
| NDUFC1 | -5268 |
| NDUFS2 | -5168 |
| NDUFAF4 | -4813 |
| UQCRB | -4788 |
| MT-CO2 | -4684 |
| TRAP1 | -4527 |
| NDUFB3 | -4489 |
| UQCRC1 | -3998 |
| NDUFA12 | -3458 |
| COQ10A | -3408 |
| MT-ND1 | -3379 |
| SDHA | -2974 |
| NDUFB6 | -2836 |
| SURF1 | -2478 |
| NDUFA10 | -2249 |
| NDUFAF2 | -1425 |
| MT-CYB | -1416 |
| COX7A2L | -1101 |
| MT-ND2 | -1038 |
| COX11 | -841 |
| MT-ND5 | -825 |
| SDHB | -49 |
| MT-CO1 | 171 |
| NDUFAF5 | 450 |
| NDUFA8 | 465 |
| LRPPRC | 1515 |
| UQCRFS1 | 1558 |
| SCO1 | 1628 |
| NDUFAF7 | 1679 |
| UQCRC2 | 1986 |
| NDUFAF1 | 2477 |
| NDUFS4 | 2482 |
| NDUFV3 | 2967 |
| NDUFS1 | 3094 |
| MT-ND6 | 3579 |
| NDUFV2 | 4553 |
| NDUFAF6 | 5172 |
| TMEM126B | 5267 |
| SDHD | 6067 |
| CYCS | 6358 |
| COX19 | 6490 |
| NDUFB5 | 6507 |
| COQ10B | 6571 |
| NUBPL | 6600 |
| TIMMDC1 | 6956 |
| COX20 | 7007 |
| MT-ND4 | 7163 |
| SCO2 | 7253 |
| COX16 | 8000 |
| ETFA | 9420 |
| NDUFA9 | 9503 |
| ETFDH | 9566 |
| NDUFA5 | 9749 |
| COX18 | 11257 |
SUMOylation of immune response proteins
| 1051 | |
|---|---|
| set | SUMOylation of immune response proteins |
| setSize | 11 |
| pANOVA | 0.0267 |
| s.dist | -0.386 |
| p.adjustANOVA | 0.109 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RELA | -6310 |
| NFKBIA | -5834 |
| IKBKE | -5767 |
| PIAS4 | -5632 |
| UBE2I | -5323 |
| NFKB2 | -5058 |
| IKBKG | -3420 |
| PIAS3 | 401 |
| TOPORS | 697 |
| SUMO3 | 2572 |
| SUMO1 | 5453 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RELA | -6310 |
| NFKBIA | -5834 |
| IKBKE | -5767 |
| PIAS4 | -5632 |
| UBE2I | -5323 |
| NFKB2 | -5058 |
| IKBKG | -3420 |
| PIAS3 | 401 |
| TOPORS | 697 |
| SUMO3 | 2572 |
| SUMO1 | 5453 |
Repression of WNT target genes
| 998 | |
|---|---|
| set | Repression of WNT target genes |
| setSize | 14 |
| pANOVA | 0.0125 |
| s.dist | -0.386 |
| p.adjustANOVA | 0.0661 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| TLE5 | -9192 |
| TLE1 | -7750 |
| TLE2 | -7594 |
| HDAC1 | -7004 |
| TCF7 | -6943 |
| CTBP1 | -6816 |
| MYC | -5063 |
| TLE3 | -3209 |
| LEF1 | -563 |
| AXIN2 | -109 |
| CTBP2 | -27 |
| TCF7L1 | 2675 |
| TLE4 | 3025 |
| TCF7L2 | 12714 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| TLE5 | -9192 |
| TLE1 | -7750 |
| TLE2 | -7594 |
| HDAC1 | -7004 |
| TCF7 | -6943 |
| CTBP1 | -6816 |
| MYC | -5063 |
| TLE3 | -3209 |
| LEF1 | -563 |
| AXIN2 | -109 |
| CTBP2 | -27 |
| TCF7L1 | 2675 |
| TLE4 | 3025 |
| TCF7L2 | 12714 |
Pentose phosphate pathway
| 808 | |
|---|---|
| set | Pentose phosphate pathway |
| setSize | 13 |
| pANOVA | 0.0166 |
| s.dist | -0.384 |
| p.adjustANOVA | 0.0816 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| PGLS | -8494 |
| RPIA | -7460 |
| PRPS1 | -6922 |
| RBKS | -6594 |
| G6PD | -6556 |
| TKT | -5745 |
| PGM2 | -4711 |
| PGD | -3706 |
| SHPK | -2507 |
| TALDO1 | -2061 |
| RPE | 3812 |
| DERA | 7957 |
| PRPS2 | 9967 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| PGLS | -8494 |
| RPIA | -7460 |
| PRPS1 | -6922 |
| RBKS | -6594 |
| G6PD | -6556 |
| TKT | -5745 |
| PGM2 | -4711 |
| PGD | -3706 |
| SHPK | -2507 |
| TALDO1 | -2061 |
| RPE | 3812 |
| DERA | 7957 |
| PRPS2 | 9967 |
Downregulation of ERBB2:ERBB3 signaling
| 305 | |
|---|---|
| set | Downregulation of ERBB2:ERBB3 signaling |
| setSize | 12 |
| pANOVA | 0.0218 |
| s.dist | -0.382 |
| p.adjustANOVA | 0.096 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| AKT2 | -8795 |
| AKT1 | -8208 |
| UBB | -6801 |
| NRG1 | -5617 |
| ERBB2 | -2941 |
| RNF41 | 208 |
| AKT3 | 951 |
| UBC | 972 |
| ERBB3 | 5486 |
| USP8 | 12629 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| AKT2 | -8795 |
| AKT1 | -8208 |
| UBB | -6801 |
| NRG1 | -5617 |
| ERBB2 | -2941 |
| RNF41 | 208 |
| AKT3 | 951 |
| UBC | 972 |
| ERBB3 | 5486 |
| USP8 | 12629 |
FOXO-mediated transcription of cell death genes
| 372 | |
|---|---|
| set | FOXO-mediated transcription of cell death genes |
| setSize | 16 |
| pANOVA | 0.0084 |
| s.dist | -0.381 |
| p.adjustANOVA | 0.0503 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| STK11 | -8262 |
| FOXO4 | -8042 |
| PINK1 | -7349 |
| FASLG | -6562 |
| FOXO1 | -5922 |
| BBC3 | -5526 |
| CREBBP | -5185 |
| FOXO3 | -3539 |
| NFYA | -1805 |
| BCL6 | -969 |
| CITED2 | -223 |
| NFYC | 757 |
| NFYB | 2007 |
| EP300 | 2665 |
| DDIT3 | 2799 |
| BCL2L11 | 5073 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| STK11 | -8262 |
| FOXO4 | -8042 |
| PINK1 | -7349 |
| FASLG | -6562 |
| FOXO1 | -5922 |
| BBC3 | -5526 |
| CREBBP | -5185 |
| FOXO3 | -3539 |
| NFYA | -1805 |
| BCL6 | -969 |
| CITED2 | -223 |
| NFYC | 757 |
| NFYB | 2007 |
| EP300 | 2665 |
| DDIT3 | 2799 |
| BCL2L11 | 5073 |
mRNA Splicing - Minor Pathway
| 1339 | |
|---|---|
| set | mRNA Splicing - Minor Pathway |
| setSize | 52 |
| pANOVA | 2.22e-06 |
| s.dist | -0.379 |
| p.adjustANOVA | 4.45e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| SNRPD2 | -9315 |
| POLR2F | -8986 |
| SF3B5 | -8950 |
| SNRNP25 | -8812 |
| POLR2I | -8796 |
| TXNL4A | -8774 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| SNU13 | -8555 |
| SNRPF | -8404 |
| SRSF1 | -8297 |
| POLR2H | -8250 |
| SNRPB | -8165 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| LSM2 | -6854 |
| SNRNP200 | -6267 |
| PRPF8 | -6129 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| POLR2L | -9320 |
| SNRPD2 | -9315 |
| POLR2F | -8986 |
| SF3B5 | -8950 |
| SNRNP25 | -8812 |
| POLR2I | -8796 |
| TXNL4A | -8774 |
| POLR2G | -8692 |
| POLR2E | -8653 |
| POLR2J | -8559 |
| SNU13 | -8555 |
| SNRPF | -8404 |
| SRSF1 | -8297 |
| POLR2H | -8250 |
| SNRPB | -8165 |
| POLR2C | -7422 |
| GTF2F1 | -7297 |
| LSM2 | -6854 |
| SNRNP200 | -6267 |
| PRPF8 | -6129 |
| SNRPE | -5550 |
| SRSF2 | -5472 |
| DDX42 | -5196 |
| SF3B2 | -4532 |
| PRPF6 | -4288 |
| DDX23 | -4149 |
| SNRPD3 | -3905 |
| YBX1 | -3641 |
| EFTUD2 | -3176 |
| PDCD7 | -2878 |
| ZMAT5 | -2439 |
| SRSF6 | -2201 |
| SNRNP40 | -1807 |
| SF3B3 | -1219 |
| SF3B4 | -706 |
| SNRPG | -170 |
| SF3B1 | 52 |
| POLR2A | 147 |
| SRSF7 | 334 |
| POLR2B | 1638 |
| SF3B6 | 1899 |
| GTF2F2 | 2060 |
| SNRPD1 | 3690 |
| POLR2D | 4368 |
| POLR2K | 5408 |
| ZRSR2 | 7174 |
| ZCRB1 | 8775 |
| SNRNP35 | 8914 |
| RNPC3 | 9507 |
| NCBP2 | 9598 |
| NCBP1 | 11061 |
| SNRNP48 | 12027 |
Condensation of Prometaphase Chromosomes
| 205 | |
|---|---|
| set | Condensation of Prometaphase Chromosomes |
| setSize | 11 |
| pANOVA | 0.0303 |
| s.dist | 0.377 |
| p.adjustANOVA | 0.119 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| SMC4 | 12457 |
| SMC2 | 11710 |
| CDK1 | 9996 |
| NCAPH | 9438 |
| NCAPG | 8224 |
| CSNK2A2 | 4585 |
| CCNB1 | 3651 |
| CSNK2A1 | 3039 |
| CCNB2 | 2770 |
| CSNK2B | -129 |
| NCAPD2 | -1141 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| SMC4 | 12457 |
| SMC2 | 11710 |
| CDK1 | 9996 |
| NCAPH | 9438 |
| NCAPG | 8224 |
| CSNK2A2 | 4585 |
| CCNB1 | 3651 |
| CSNK2A1 | 3039 |
| CCNB2 | 2770 |
| CSNK2B | -129 |
| NCAPD2 | -1141 |
Mitochondrial translation initiation
| 672 | |
|---|---|
| set | Mitochondrial translation initiation |
| setSize | 91 |
| pANOVA | 6.78e-10 |
| s.dist | -0.374 |
| p.adjustANOVA | 2.06e-08 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MRPL54 | -9340 |
| MRPS34 | -9339 |
| MRPL43 | -9298 |
| MRPL24 | -9275 |
| MRPL34 | -9149 |
| MRPS7 | -9105 |
| MRPS12 | -8913 |
| MRPL12 | -8895 |
| MRPS26 | -8846 |
| MRPS24 | -8845 |
| MRPL28 | -8761 |
| AURKAIP1 | -8713 |
| MRPL11 | -8607 |
| CHCHD1 | -8411 |
| MRPL53 | -8374 |
| MRPS21 | -8373 |
| MRPL23 | -8360 |
| MRPS2 | -8271 |
| MRPL14 | -8114 |
| GADD45GIP1 | -7982 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MRPL54 | -9340 |
| MRPS34 | -9339 |
| MRPL43 | -9298 |
| MRPL24 | -9275 |
| MRPL34 | -9149 |
| MRPS7 | -9105 |
| MRPS12 | -8913 |
| MRPL12 | -8895 |
| MRPS26 | -8846 |
| MRPS24 | -8845 |
| MRPL28 | -8761 |
| AURKAIP1 | -8713 |
| MRPL11 | -8607 |
| CHCHD1 | -8411 |
| MRPL53 | -8374 |
| MRPS21 | -8373 |
| MRPL23 | -8360 |
| MRPS2 | -8271 |
| MRPL14 | -8114 |
| GADD45GIP1 | -7982 |
| MRPL38 | -7787 |
| MRPL58 | -7637 |
| MRPL55 | -7343 |
| MRPL51 | -7338 |
| MRPL49 | -7324 |
| MRPS6 | -7144 |
| MRPS15 | -7058 |
| MRPL9 | -6497 |
| MRPL57 | -6464 |
| MRPL36 | -6416 |
| MRPL37 | -6166 |
| MT-TV | -5819 |
| MRPL40 | -5780 |
| MRPL17 | -5578 |
| MRPL41 | -5502 |
| MRPL45 | -5466 |
| MRPL27 | -5431 |
| MRPS16 | -5371 |
| MRPL52 | -5331 |
| MRPS33 | -5090 |
| MRPS23 | -4820 |
| MRPL21 | -4329 |
| MRPL46 | -4059 |
| DAP3 | -4000 |
| MRPL15 | -3999 |
| MRPL48 | -3963 |
| MRPS28 | -3944 |
| MRPL20 | -3929 |
| MRPL33 | -3795 |
| OXA1L | -3336 |
| MRPL2 | -3011 |
| MRPL3 | -2323 |
| MRPS11 | -2021 |
| MRPS18A | -1821 |
| MRPL18 | -1770 |
| MRPS9 | -1753 |
| MRPS30 | -1700 |
| MRPL16 | -1220 |
| MRPS25 | -1098 |
| MRPL30 | -797 |
| MRPS17 | -505 |
| ERAL1 | -373 |
| MTFMT | -219 |
| MRPS36 | -145 |
| MRPL4 | -92 |
| MT-RNR1 | 149 |
| MRPL10 | 424 |
| MRPS18B | 609 |
| MT-RNR2 | 677 |
| MRPL22 | 776 |
| MRPS27 | 1043 |
| MRPS5 | 2527 |
| MRPL32 | 2842 |
| MRPL35 | 3271 |
| MRPS18C | 3355 |
| MRPL50 | 3474 |
| MRPL44 | 4611 |
| MRPS14 | 5512 |
| PTCD3 | 5651 |
| MRPS22 | 6337 |
| MRPS31 | 7153 |
| MRPL19 | 7255 |
| MRPL47 | 8014 |
| MRPL13 | 8300 |
| MRPS10 | 8421 |
| MRPL39 | 8523 |
| MRPS35 | 9329 |
| MTIF2 | 9342 |
| MRPL1 | 9363 |
| MTIF3 | 10838 |
| MRPL42 | 12516 |
Regulation of localization of FOXO transcription factors
| 988 | |
|---|---|
| set | Regulation of localization of FOXO transcription factors |
| setSize | 12 |
| pANOVA | 0.0252 |
| s.dist | -0.373 |
| p.adjustANOVA | 0.105 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| AKT2 | -8795 |
| AKT1 | -8208 |
| FOXO4 | -8042 |
| FOXO1 | -5922 |
| FOXO6 | -4190 |
| YWHAG | -3607 |
| FOXO3 | -3539 |
| SFN | -2671 |
| YWHAQ | -2132 |
| AKT3 | 951 |
| YWHAZ | 6860 |
| YWHAB | 10200 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| AKT2 | -8795 |
| AKT1 | -8208 |
| FOXO4 | -8042 |
| FOXO1 | -5922 |
| FOXO6 | -4190 |
| YWHAG | -3607 |
| FOXO3 | -3539 |
| SFN | -2671 |
| YWHAQ | -2132 |
| AKT3 | 951 |
| YWHAZ | 6860 |
| YWHAB | 10200 |
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
| 32 | |
|---|---|
| set | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
| setSize | 22 |
| pANOVA | 0.00265 |
| s.dist | -0.37 |
| p.adjustANOVA | 0.022 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900.0 |
| H2BC12 | -7886.0 |
| H2AZ2 | -7692.0 |
| H2AJ | -7409.0 |
| PKN1 | -6442.0 |
| H3C15 | -5601.5 |
| KDM1A | -5518.0 |
| H2BC5 | -5076.0 |
| H2BC11 | -4577.0 |
| H2BC15 | -4551.0 |
| H2BC9 | -2948.0 |
| H2AC6 | -2807.0 |
| H2BC17 | -2534.0 |
| H2BC21 | -2274.0 |
| H2BU1 | -1593.0 |
| KDM4C | -1174.0 |
| H2BC4 | -607.0 |
| H3-3A | 1111.0 |
| H2AC20 | 3617.0 |
| AR | 4195.0 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900.0 |
| H2BC12 | -7886.0 |
| H2AZ2 | -7692.0 |
| H2AJ | -7409.0 |
| PKN1 | -6442.0 |
| H3C15 | -5601.5 |
| KDM1A | -5518.0 |
| H2BC5 | -5076.0 |
| H2BC11 | -4577.0 |
| H2BC15 | -4551.0 |
| H2BC9 | -2948.0 |
| H2AC6 | -2807.0 |
| H2BC17 | -2534.0 |
| H2BC21 | -2274.0 |
| H2BU1 | -1593.0 |
| KDM4C | -1174.0 |
| H2BC4 | -607.0 |
| H3-3A | 1111.0 |
| H2AC20 | 3617.0 |
| AR | 4195.0 |
| NCOA2 | 5566.0 |
| KLK2 | 10530.0 |
Mitochondrial translation termination
| 673 | |
|---|---|
| set | Mitochondrial translation termination |
| setSize | 91 |
| pANOVA | 1.26e-09 |
| s.dist | -0.368 |
| p.adjustANOVA | 3.75e-08 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MRPL54 | -9340 |
| MRPS34 | -9339 |
| MRPL43 | -9298 |
| MRPL24 | -9275 |
| MRPL34 | -9149 |
| MRPS7 | -9105 |
| MRPS12 | -8913 |
| MRPL12 | -8895 |
| MRPS26 | -8846 |
| MRPS24 | -8845 |
| MRPL28 | -8761 |
| AURKAIP1 | -8713 |
| MRPL11 | -8607 |
| CHCHD1 | -8411 |
| MRPL53 | -8374 |
| MRPS21 | -8373 |
| MRPL23 | -8360 |
| MRPS2 | -8271 |
| MRPL14 | -8114 |
| GADD45GIP1 | -7982 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MRPL54 | -9340 |
| MRPS34 | -9339 |
| MRPL43 | -9298 |
| MRPL24 | -9275 |
| MRPL34 | -9149 |
| MRPS7 | -9105 |
| MRPS12 | -8913 |
| MRPL12 | -8895 |
| MRPS26 | -8846 |
| MRPS24 | -8845 |
| MRPL28 | -8761 |
| AURKAIP1 | -8713 |
| MRPL11 | -8607 |
| CHCHD1 | -8411 |
| MRPL53 | -8374 |
| MRPS21 | -8373 |
| MRPL23 | -8360 |
| MRPS2 | -8271 |
| MRPL14 | -8114 |
| GADD45GIP1 | -7982 |
| MRPL38 | -7787 |
| MRPL58 | -7637 |
| MRPL55 | -7343 |
| MRPL51 | -7338 |
| MRPL49 | -7324 |
| MRPS6 | -7144 |
| MRPS15 | -7058 |
| MRPL9 | -6497 |
| MRPL57 | -6464 |
| MRPL36 | -6416 |
| MRPL37 | -6166 |
| MT-TV | -5819 |
| MRPL40 | -5780 |
| MRPL17 | -5578 |
| MRPL41 | -5502 |
| MRPL45 | -5466 |
| MRPL27 | -5431 |
| MRPS16 | -5371 |
| MRPL52 | -5331 |
| MRPS33 | -5090 |
| MRPS23 | -4820 |
| MRPL21 | -4329 |
| MRPL46 | -4059 |
| DAP3 | -4000 |
| MRPL15 | -3999 |
| MRPL48 | -3963 |
| MRPS28 | -3944 |
| MRPL20 | -3929 |
| MRPL33 | -3795 |
| OXA1L | -3336 |
| MRPL2 | -3011 |
| MRPL3 | -2323 |
| MRPS11 | -2021 |
| MRPS18A | -1821 |
| MRPL18 | -1770 |
| MRPS9 | -1753 |
| MRPS30 | -1700 |
| MRPL16 | -1220 |
| MRPS25 | -1098 |
| MRPL30 | -797 |
| MRPS17 | -505 |
| ERAL1 | -373 |
| MRPS36 | -145 |
| MRPL4 | -92 |
| MT-RNR1 | 149 |
| MRPL10 | 424 |
| MRPS18B | 609 |
| MT-RNR2 | 677 |
| MRPL22 | 776 |
| MRPS27 | 1043 |
| MRPS5 | 2527 |
| MRPL32 | 2842 |
| MRPL35 | 3271 |
| MRPS18C | 3355 |
| MRPL50 | 3474 |
| MRPL44 | 4611 |
| MRPS14 | 5512 |
| PTCD3 | 5651 |
| MRPS22 | 6337 |
| MRPS31 | 7153 |
| MRPL19 | 7255 |
| MRRF | 7652 |
| MRPL47 | 8014 |
| MRPL13 | 8300 |
| MRPS10 | 8421 |
| GFM2 | 8453 |
| MRPL39 | 8523 |
| MRPS35 | 9329 |
| MRPL1 | 9363 |
| MTRF1L | 9883 |
| MRPL42 | 12516 |
HSF1 activation
| 489 | |
|---|---|
| set | HSF1 activation |
| setSize | 26 |
| pANOVA | 0.0012 |
| s.dist | -0.367 |
| p.adjustANOVA | 0.0121 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| EEF1A1 | -8699 |
| DNAJB1 | -8595 |
| SERPINH1 | -8066 |
| DEDD2 | -6963 |
| RPA1 | -6841 |
| UBB | -6801 |
| FKBP4 | -6645 |
| VCP | -6462 |
| HSPA1A | -5222 |
| HSF1 | -5065 |
| HSPA1L | -4338 |
| HSP90AB1 | -3612 |
| RLN1 | -3385 |
| TNFRSF21 | -3225 |
| DNAJB6 | -2641 |
| HSPA1B | -1882 |
| MRPL18 | -1770 |
| HSPA6 | -1136 |
| RPA3 | -1081 |
| HDAC6 | 292 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| EEF1A1 | -8699 |
| DNAJB1 | -8595 |
| SERPINH1 | -8066 |
| DEDD2 | -6963 |
| RPA1 | -6841 |
| UBB | -6801 |
| FKBP4 | -6645 |
| VCP | -6462 |
| HSPA1A | -5222 |
| HSF1 | -5065 |
| HSPA1L | -4338 |
| HSP90AB1 | -3612 |
| RLN1 | -3385 |
| TNFRSF21 | -3225 |
| DNAJB6 | -2641 |
| HSPA1B | -1882 |
| MRPL18 | -1770 |
| HSPA6 | -1136 |
| RPA3 | -1081 |
| HDAC6 | 292 |
| RPA2 | 676 |
| HSBP1 | 4811 |
| HSPH1 | 5385 |
| YWHAE | 5754 |
| HSP90AA1 | 6784 |
| PTGES3 | 7569 |
Folding of actin by CCT/TriC
| 385 | |
|---|---|
| set | Folding of actin by CCT/TriC |
| setSize | 10 |
| pANOVA | 0.045 |
| s.dist | -0.366 |
| p.adjustANOVA | 0.154 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| CCT3 | -8192 |
| CCT7 | -7856 |
| CCT6A | -5476 |
| CCT4 | -4480 |
| CCT2 | -1641 |
| ACTB | -937 |
| TCP1 | -880 |
| CCT5 | -723 |
| CCT8 | -441 |
| CCT6B | 7167 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| CCT3 | -8192 |
| CCT7 | -7856 |
| CCT6A | -5476 |
| CCT4 | -4480 |
| CCT2 | -1641 |
| ACTB | -937 |
| TCP1 | -880 |
| CCT5 | -723 |
| CCT8 | -441 |
| CCT6B | 7167 |
Regulation of TP53 Activity through Association with Co-factors
| 973 | |
|---|---|
| set | Regulation of TP53 Activity through Association with Co-factors |
| setSize | 12 |
| pANOVA | 0.0284 |
| s.dist | -0.365 |
| p.adjustANOVA | 0.113 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| PPP1R13L | -9123 |
| AKT2 | -8795 |
| AKT1 | -8208 |
| PPP1R13B | -5934 |
| BANP | -4004 |
| TP53 | -2156 |
| TP73 | -1412 |
| ZNF385A | -895 |
| PHF20 | 612 |
| AKT3 | 951 |
| TP63 | 5242 |
| TP53BP2 | 5677 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| PPP1R13L | -9123 |
| AKT2 | -8795 |
| AKT1 | -8208 |
| PPP1R13B | -5934 |
| BANP | -4004 |
| TP53 | -2156 |
| TP73 | -1412 |
| ZNF385A | -895 |
| PHF20 | 612 |
| AKT3 | 951 |
| TP63 | 5242 |
| TP53BP2 | 5677 |
SLBP independent Processing of Histone Pre-mRNAs
| 1037 | |
|---|---|
| set | SLBP independent Processing of Histone Pre-mRNAs |
| setSize | 10 |
| pANOVA | 0.0459 |
| s.dist | -0.365 |
| p.adjustANOVA | 0.157 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| SNRPF | -8404 |
| SNRPB | -8165 |
| LSM11 | -7714 |
| ZNF473 | -5940 |
| SNRPE | -5550 |
| LSM10 | -4113 |
| SNRPD3 | -3905 |
| SNRPG | -170 |
| NCBP2 | 9598 |
| NCBP1 | 11061 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| SNRPF | -8404 |
| SNRPB | -8165 |
| LSM11 | -7714 |
| ZNF473 | -5940 |
| SNRPE | -5550 |
| LSM10 | -4113 |
| SNRPD3 | -3905 |
| SNRPG | -170 |
| NCBP2 | 9598 |
| NCBP1 | 11061 |
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
| 1004 | |
|---|---|
| set | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| setSize | 26 |
| pANOVA | 0.00135 |
| s.dist | 0.363 |
| p.adjustANOVA | 0.0132 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RAD50 | 12622 |
| RBBP8 | 12611 |
| BRCA2 | 12458 |
| RMI2 | 12095 |
| RMI1 | 11962 |
| NBN | 11290 |
| DNA2 | 11174 |
| RAD51 | 10954 |
| RAD51B | 10714 |
| BRIP1 | 10178 |
| BRCA1 | 9618 |
| RAD51AP1 | 8527 |
| PALB2 | 7990 |
| RAD51C | 7557 |
| BARD1 | 5845 |
| TOP3A | 4985 |
| EXO1 | 3576 |
| WRN | 3116 |
| ATM | 53 |
| XRCC2 | -87 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RAD50 | 12622 |
| RBBP8 | 12611 |
| BRCA2 | 12458 |
| RMI2 | 12095 |
| RMI1 | 11962 |
| NBN | 11290 |
| DNA2 | 11174 |
| RAD51 | 10954 |
| RAD51B | 10714 |
| BRIP1 | 10178 |
| BRCA1 | 9618 |
| RAD51AP1 | 8527 |
| PALB2 | 7990 |
| RAD51C | 7557 |
| BARD1 | 5845 |
| TOP3A | 4985 |
| EXO1 | 3576 |
| WRN | 3116 |
| ATM | 53 |
| XRCC2 | -87 |
| BLM | -1004 |
| RTEL1 | -1349 |
| RAD51D | -1992 |
| MRE11 | -4699 |
| XRCC3 | -4762 |
| KAT5 | -4883 |
Attenuation phase
| 94 | |
|---|---|
| set | Attenuation phase |
| setSize | 23 |
| pANOVA | 0.00258 |
| s.dist | -0.363 |
| p.adjustANOVA | 0.0217 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| DNAJB1 | -8595 |
| SERPINH1 | -8066 |
| DEDD2 | -6963 |
| UBB | -6801 |
| FKBP4 | -6645 |
| HSPA2 | -5627 |
| HSPA1A | -5222 |
| CREBBP | -5185 |
| HSF1 | -5065 |
| HSPA1L | -4338 |
| HSP90AB1 | -3612 |
| RLN1 | -3385 |
| TNFRSF21 | -3225 |
| DNAJB6 | -2641 |
| HSPA1B | -1882 |
| MRPL18 | -1770 |
| HSPA6 | -1136 |
| HSPA8 | -190 |
| EP300 | 2665 |
| HSBP1 | 4811 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| DNAJB1 | -8595 |
| SERPINH1 | -8066 |
| DEDD2 | -6963 |
| UBB | -6801 |
| FKBP4 | -6645 |
| HSPA2 | -5627 |
| HSPA1A | -5222 |
| CREBBP | -5185 |
| HSF1 | -5065 |
| HSPA1L | -4338 |
| HSP90AB1 | -3612 |
| RLN1 | -3385 |
| TNFRSF21 | -3225 |
| DNAJB6 | -2641 |
| HSPA1B | -1882 |
| MRPL18 | -1770 |
| HSPA6 | -1136 |
| HSPA8 | -190 |
| EP300 | 2665 |
| HSBP1 | 4811 |
| HSPH1 | 5385 |
| HSP90AA1 | 6784 |
| PTGES3 | 7569 |
Cleavage of the damaged pyrimidine
| 194 | |
|---|---|
| set | Cleavage of the damaged pyrimidine |
| setSize | 29 |
| pANOVA | 0.000717 |
| s.dist | -0.363 |
| p.adjustANOVA | 0.00777 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| NEIL1 | -7681 |
| H2AJ | -7409 |
| UNG | -6905 |
| TINF2 | -6560 |
| NTHL1 | -5718 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| NEIL2 | -3484 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| NEIL1 | -7681 |
| H2AJ | -7409 |
| UNG | -6905 |
| TINF2 | -6560 |
| NTHL1 | -5718 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| NEIL2 | -3484 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
| MBD4 | 3242 |
| SMUG1 | 3331 |
| H2AC20 | 3617 |
| NEIL3 | 4420 |
| TERF1 | 6253 |
| TDG | 6297 |
| POT1 | 9092 |
Depyrimidination
| 278 | |
|---|---|
| set | Depyrimidination |
| setSize | 29 |
| pANOVA | 0.000717 |
| s.dist | -0.363 |
| p.adjustANOVA | 0.00777 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| NEIL1 | -7681 |
| H2AJ | -7409 |
| UNG | -6905 |
| TINF2 | -6560 |
| NTHL1 | -5718 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| NEIL2 | -3484 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| NEIL1 | -7681 |
| H2AJ | -7409 |
| UNG | -6905 |
| TINF2 | -6560 |
| NTHL1 | -5718 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| NEIL2 | -3484 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
| MBD4 | 3242 |
| SMUG1 | 3331 |
| H2AC20 | 3617 |
| NEIL3 | 4420 |
| TERF1 | 6253 |
| TDG | 6297 |
| POT1 | 9092 |
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
| 940 | |
|---|---|
| set | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| setSize | 29 |
| pANOVA | 0.000717 |
| s.dist | -0.363 |
| p.adjustANOVA | 0.00777 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| NEIL1 | -7681 |
| H2AJ | -7409 |
| UNG | -6905 |
| TINF2 | -6560 |
| NTHL1 | -5718 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| NEIL2 | -3484 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| H2AZ1 | -8900 |
| ACD | -8254 |
| H2BC12 | -7886 |
| H2AZ2 | -7692 |
| NEIL1 | -7681 |
| H2AJ | -7409 |
| UNG | -6905 |
| TINF2 | -6560 |
| NTHL1 | -5718 |
| TERF2IP | -5398 |
| H2BC5 | -5076 |
| H2BC11 | -4577 |
| H2BC15 | -4551 |
| NEIL2 | -3484 |
| H2BC9 | -2948 |
| H2AC6 | -2807 |
| H2BC17 | -2534 |
| H2BC21 | -2274 |
| OGG1 | -1684 |
| H2BU1 | -1593 |
| H2BC4 | -607 |
| TERF2 | 1365 |
| MBD4 | 3242 |
| SMUG1 | 3331 |
| H2AC20 | 3617 |
| NEIL3 | 4420 |
| TERF1 | 6253 |
| TDG | 6297 |
| POT1 | 9092 |
The role of Nef in HIV-1 replication and disease pathogenesis
| 1232 | |
|---|---|
| set | The role of Nef in HIV-1 replication and disease pathogenesis |
| setSize | 28 |
| pANOVA | 0.000908 |
| s.dist | -0.362 |
| p.adjustANOVA | 0.00939 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| HLA-A | -9042 |
| AP2M1 | -8551 |
| AP1M1 | -8099 |
| CD247 | -7536 |
| AP2A2 | -7462 |
| LCK | -7236 |
| AP1S1 | -7234 |
| ARF1 | -6757 |
| CD28 | -6478 |
| PACS1 | -6471 |
| AP2S1 | -5881 |
| AP1B1 | -4779 |
| CD4 | -4377 |
| ELMO1 | -4215 |
| AP2B1 | -3883 |
| FYN | -3210 |
| ATP6V1H | -2263 |
| AP1M2 | -2193 |
| CD8B | 250 |
| AP2A1 | 323 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| HLA-A | -9042 |
| AP2M1 | -8551 |
| AP1M1 | -8099 |
| CD247 | -7536 |
| AP2A2 | -7462 |
| LCK | -7236 |
| AP1S1 | -7234 |
| ARF1 | -6757 |
| CD28 | -6478 |
| PACS1 | -6471 |
| AP2S1 | -5881 |
| AP1B1 | -4779 |
| CD4 | -4377 |
| ELMO1 | -4215 |
| AP2B1 | -3883 |
| FYN | -3210 |
| ATP6V1H | -2263 |
| AP1M2 | -2193 |
| CD8B | 250 |
| AP2A1 | 323 |
| DOCK2 | 1578 |
| HCK | 2692 |
| AP1S3 | 2906 |
| AP1G1 | 3191 |
| B2M | 6409 |
| PAK2 | 7403 |
| RAC1 | 8106 |
| AP1S2 | 8413 |
SUMOylation of DNA methylation proteins
| 1046 | |
|---|---|
| set | SUMOylation of DNA methylation proteins |
| setSize | 16 |
| pANOVA | 0.0121 |
| s.dist | -0.362 |
| p.adjustANOVA | 0.0655 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RING1 | -8914 |
| PHC1 | -8598 |
| CBX2 | -7477 |
| DNMT3A | -7229 |
| SCMH1 | -6769 |
| CBX4 | -5994 |
| DNMT1 | -5812 |
| UBE2I | -5323 |
| CBX8 | -3753 |
| DNMT3B | -3110 |
| PHC2 | -2556 |
| BMI1 | 2872 |
| SUMO1 | 5453 |
| PCGF2 | 5724 |
| RNF2 | 5928 |
| PHC3 | 8730 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RING1 | -8914 |
| PHC1 | -8598 |
| CBX2 | -7477 |
| DNMT3A | -7229 |
| SCMH1 | -6769 |
| CBX4 | -5994 |
| DNMT1 | -5812 |
| UBE2I | -5323 |
| CBX8 | -3753 |
| DNMT3B | -3110 |
| PHC2 | -2556 |
| BMI1 | 2872 |
| SUMO1 | 5453 |
| PCGF2 | 5724 |
| RNF2 | 5928 |
| PHC3 | 8730 |
rRNA processing in the mitochondrion
| 1356 | |
|---|---|
| set | rRNA processing in the mitochondrion |
| setSize | 29 |
| pANOVA | 0.00079 |
| s.dist | -0.36 |
| p.adjustANOVA | 0.00828 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MT-ATP8 | -8945 |
| MRM1 | -7820 |
| MT-CO3 | -7585 |
| MTERF4 | -6960 |
| MT-ATP6 | -6906 |
| HSD17B10 | -6363 |
| MT-ND3 | -6232 |
| ELAC2 | -5953 |
| MT-TV | -5819 |
| MT-ND4L | -5454 |
| MT-CO2 | -4684 |
| MRM3 | -4475 |
| MT-TF | -4357 |
| MT-TM | -3832 |
| MT-TL2 | -3777 |
| MT-ND1 | -3379 |
| MRM2 | -2325 |
| MT-CYB | -1416 |
| MT-ND2 | -1038 |
| MT-ND5 | -825 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MT-ATP8 | -8945 |
| MRM1 | -7820 |
| MT-CO3 | -7585 |
| MTERF4 | -6960 |
| MT-ATP6 | -6906 |
| HSD17B10 | -6363 |
| MT-ND3 | -6232 |
| ELAC2 | -5953 |
| MT-TV | -5819 |
| MT-ND4L | -5454 |
| MT-CO2 | -4684 |
| MRM3 | -4475 |
| MT-TF | -4357 |
| MT-TM | -3832 |
| MT-TL2 | -3777 |
| MT-ND1 | -3379 |
| MRM2 | -2325 |
| MT-CYB | -1416 |
| MT-ND2 | -1038 |
| MT-ND5 | -825 |
| MT-RNR1 | 149 |
| MT-CO1 | 171 |
| MT-RNR2 | 677 |
| MT-TL1 | 1060 |
| PRORP | 3101 |
| TFB1M | 4233 |
| TRMT10C | 6586 |
| MT-ND4 | 7163 |
| NSUN4 | 9005 |
Acetylcholine Neurotransmitter Release Cycle
| 30 | |
|---|---|
| set | Acetylcholine Neurotransmitter Release Cycle |
| setSize | 11 |
| pANOVA | 0.0437 |
| s.dist | -0.351 |
| p.adjustANOVA | 0.152 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| PPFIA3 | -9290 |
| RAB3A | -8077 |
| TSPOAP1 | -7421 |
| STXBP1 | -6277 |
| UNC13B | -6110 |
| CPLX1 | -4394 |
| STX1A | -3318 |
| VAMP2 | -3120 |
| SYT1 | 6270 |
| PPFIA1 | 7738 |
| PPFIA4 | 9995 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| PPFIA3 | -9290 |
| RAB3A | -8077 |
| TSPOAP1 | -7421 |
| STXBP1 | -6277 |
| UNC13B | -6110 |
| CPLX1 | -4394 |
| STX1A | -3318 |
| VAMP2 | -3120 |
| SYT1 | 6270 |
| PPFIA1 | 7738 |
| PPFIA4 | 9995 |
Spry regulation of FGF signaling
| 1153 | |
|---|---|
| set | Spry regulation of FGF signaling |
| setSize | 16 |
| pANOVA | 0.0152 |
| s.dist | -0.35 |
| p.adjustANOVA | 0.0762 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MAPK3 | -9318 |
| RPS27A | -9287 |
| UBA52 | -8911 |
| PPP2R1A | -8336 |
| SPRY2 | -6969 |
| UBB | -6801 |
| CBL | -3590 |
| GRB2 | -1365 |
| PPP2CA | 470 |
| MAPK1 | 671 |
| UBC | 972 |
| SRC | 1930 |
| PTPN11 | 2199 |
| BRAF | 4400 |
| MKNK1 | 4542 |
| PPP2CB | 4642 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MAPK3 | -9318 |
| RPS27A | -9287 |
| UBA52 | -8911 |
| PPP2R1A | -8336 |
| SPRY2 | -6969 |
| UBB | -6801 |
| CBL | -3590 |
| GRB2 | -1365 |
| PPP2CA | 470 |
| MAPK1 | 671 |
| UBC | 972 |
| SRC | 1930 |
| PTPN11 | 2199 |
| BRAF | 4400 |
| MKNK1 | 4542 |
| PPP2CB | 4642 |
Mitochondrial translation
| 670 | |
|---|---|
| set | Mitochondrial translation |
| setSize | 97 |
| pANOVA | 2.56e-09 |
| s.dist | -0.35 |
| p.adjustANOVA | 7.43e-08 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MRPL54 | -9340 |
| MRPS34 | -9339 |
| MRPL43 | -9298 |
| MRPL24 | -9275 |
| MRPL34 | -9149 |
| MRPS7 | -9105 |
| MRPS12 | -8913 |
| MRPL12 | -8895 |
| MRPS26 | -8846 |
| MRPS24 | -8845 |
| MRPL28 | -8761 |
| TUFM | -8744 |
| AURKAIP1 | -8713 |
| MRPL11 | -8607 |
| CHCHD1 | -8411 |
| MRPL53 | -8374 |
| MRPS21 | -8373 |
| MRPL23 | -8360 |
| MRPS2 | -8271 |
| MRPL14 | -8114 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MRPL54 | -9340 |
| MRPS34 | -9339 |
| MRPL43 | -9298 |
| MRPL24 | -9275 |
| MRPL34 | -9149 |
| MRPS7 | -9105 |
| MRPS12 | -8913 |
| MRPL12 | -8895 |
| MRPS26 | -8846 |
| MRPS24 | -8845 |
| MRPL28 | -8761 |
| TUFM | -8744 |
| AURKAIP1 | -8713 |
| MRPL11 | -8607 |
| CHCHD1 | -8411 |
| MRPL53 | -8374 |
| MRPS21 | -8373 |
| MRPL23 | -8360 |
| MRPS2 | -8271 |
| MRPL14 | -8114 |
| GADD45GIP1 | -7982 |
| MRPL38 | -7787 |
| MRPL58 | -7637 |
| MRPL55 | -7343 |
| MRPL51 | -7338 |
| MRPL49 | -7324 |
| MRPS6 | -7144 |
| MRPS15 | -7058 |
| MRPL9 | -6497 |
| MRPL57 | -6464 |
| MRPL36 | -6416 |
| MRPL37 | -6166 |
| MT-TV | -5819 |
| MRPL40 | -5780 |
| TSFM | -5709 |
| MRPL17 | -5578 |
| MRPL41 | -5502 |
| MRPL45 | -5466 |
| MRPL27 | -5431 |
| MRPS16 | -5371 |
| MRPL52 | -5331 |
| MRPS33 | -5090 |
| MRPS23 | -4820 |
| MRPL21 | -4329 |
| MRPL46 | -4059 |
| DAP3 | -4000 |
| MRPL15 | -3999 |
| MRPL48 | -3963 |
| MRPS28 | -3944 |
| MRPL20 | -3929 |
| MRPL33 | -3795 |
| OXA1L | -3336 |
| MRPL2 | -3011 |
| MRPL3 | -2323 |
| MRPS11 | -2021 |
| MRPS18A | -1821 |
| MRPL18 | -1770 |
| MRPS9 | -1753 |
| MRPS30 | -1700 |
| MRPL16 | -1220 |
| MRPS25 | -1098 |
| MRPL30 | -797 |
| MRPS17 | -505 |
| ERAL1 | -373 |
| MTFMT | -219 |
| MRPS36 | -145 |
| MRPL4 | -92 |
| GFM1 | -55 |
| MT-RNR1 | 149 |
| MRPL10 | 424 |
| MRPS18B | 609 |
| MT-RNR2 | 677 |
| MRPL22 | 776 |
| MRPS27 | 1043 |
| MRPS5 | 2527 |
| MRPL32 | 2842 |
| MRPL35 | 3271 |
| MRPS18C | 3355 |
| MRPL50 | 3474 |
| MRPL44 | 4611 |
| MRPS14 | 5512 |
| PTCD3 | 5651 |
| MRPS22 | 6337 |
| MRPS31 | 7153 |
| MRPL19 | 7255 |
| MRRF | 7652 |
| MRPL47 | 8014 |
| MRPL13 | 8300 |
| MRPS10 | 8421 |
| GFM2 | 8453 |
| MRPL39 | 8523 |
| MRPS35 | 9329 |
| MTIF2 | 9342 |
| MRPL1 | 9363 |
| MTRF1L | 9883 |
| MTIF3 | 10838 |
| MRPL42 | 12516 |
Mitochondrial protein import
| 668 | |
|---|---|
| set | Mitochondrial protein import |
| setSize | 64 |
| pANOVA | 1.52e-06 |
| s.dist | -0.347 |
| p.adjustANOVA | 3.29e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| SLC25A6 | -9360 |
| TOMM7 | -9317 |
| CHCHD2 | -9228 |
| TIMM13 | -9020 |
| TOMM40 | -8664 |
| TIMM8B | -8602 |
| GFER | -8599 |
| CHCHD5 | -8379 |
| TIMM22 | -8324 |
| NDUFB8 | -8292 |
| TIMM44 | -7935 |
| SAMM50 | -7810 |
| CYC1 | -7555 |
| COA4 | -7540 |
| COX17 | -7263 |
| ATP5F1A | -7067 |
| MTX1 | -6820 |
| TOMM5 | -6786 |
| CMC4 | -6773 |
| TOMM22 | -5904 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| SLC25A6 | -9360 |
| TOMM7 | -9317 |
| CHCHD2 | -9228 |
| TIMM13 | -9020 |
| TOMM40 | -8664 |
| TIMM8B | -8602 |
| GFER | -8599 |
| CHCHD5 | -8379 |
| TIMM22 | -8324 |
| NDUFB8 | -8292 |
| TIMM44 | -7935 |
| SAMM50 | -7810 |
| CYC1 | -7555 |
| COA4 | -7540 |
| COX17 | -7263 |
| ATP5F1A | -7067 |
| MTX1 | -6820 |
| TOMM5 | -6786 |
| CMC4 | -6773 |
| TOMM22 | -5904 |
| BCS1L | -5290 |
| CHCHD4 | -5281 |
| PMPCB | -5256 |
| IDH3G | -5202 |
| TIMM17B | -4864 |
| ACO2 | -3985 |
| CHCHD10 | -3801 |
| HSCB | -3261 |
| PMPCA | -3163 |
| PITRM1 | -2953 |
| TAZ | -2709 |
| ATP5MC1 | -2555 |
| ATP5F1B | -1757 |
| TIMM9 | -1510 |
| HSPA9 | -1103 |
| FXN | -1045 |
| HSPD1 | -972 |
| TIMM21 | -922 |
| GRPEL1 | -814 |
| CHCHD7 | -703 |
| TOMM6 | -698 |
| CHCHD3 | -182 |
| TIMM50 | -28 |
| TOMM20 | 407 |
| LDHD | 428 |
| COA6 | 635 |
| TIMM10 | 960 |
| DNAJC19 | 1168 |
| SLC25A4 | 1588 |
| TOMM70 | 1868 |
| GRPEL2 | 2003 |
| PAM16 | 2012 |
| SLC25A12 | 2082 |
| SLC25A13 | 2945 |
| MTX2 | 4274 |
| CS | 4593 |
| COQ2 | 4894 |
| TIMM10B | 5233 |
| VDAC1 | 5760 |
| COX19 | 6490 |
| TIMM23 | 7040 |
| TIMM17A | 7220 |
| TIMM8A | 7421 |
| CMC2 | 11879 |
Membrane binding and targetting of GAG proteins
| 633 | |
|---|---|
| set | Membrane binding and targetting of GAG proteins |
| setSize | 13 |
| pANOVA | 0.0307 |
| s.dist | -0.346 |
| p.adjustANOVA | 0.12 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| VPS28 | -8635 |
| VPS37B | -8112 |
| UBB | -6801 |
| MVB12A | -6540 |
| UBAP1 | -2654 |
| MVB12B | -595 |
| UBC | 972 |
| NMT2 | 3152 |
| VPS37C | 4106 |
| TSG101 | 5412 |
| VPS37A | 10275 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| VPS28 | -8635 |
| VPS37B | -8112 |
| UBB | -6801 |
| MVB12A | -6540 |
| UBAP1 | -2654 |
| MVB12B | -595 |
| UBC | 972 |
| NMT2 | 3152 |
| VPS37C | 4106 |
| TSG101 | 5412 |
| VPS37A | 10275 |
Synthesis And Processing Of GAG, GAGPOL Polyproteins
| 1163 | |
|---|---|
| set | Synthesis And Processing Of GAG, GAGPOL Polyproteins |
| setSize | 13 |
| pANOVA | 0.0307 |
| s.dist | -0.346 |
| p.adjustANOVA | 0.12 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| VPS28 | -8635 |
| VPS37B | -8112 |
| UBB | -6801 |
| MVB12A | -6540 |
| UBAP1 | -2654 |
| MVB12B | -595 |
| UBC | 972 |
| NMT2 | 3152 |
| VPS37C | 4106 |
| TSG101 | 5412 |
| VPS37A | 10275 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -9287 |
| UBA52 | -8911 |
| VPS28 | -8635 |
| VPS37B | -8112 |
| UBB | -6801 |
| MVB12A | -6540 |
| UBAP1 | -2654 |
| MVB12B | -595 |
| UBC | 972 |
| NMT2 | 3152 |
| VPS37C | 4106 |
| TSG101 | 5412 |
| VPS37A | 10275 |
CDC6 association with the ORC:origin complex
| 127 | |
|---|---|
| set | CDC6 association with the ORC:origin complex |
| setSize | 11 |
| pANOVA | 0.0478 |
| s.dist | 0.345 |
| p.adjustANOVA | 0.162 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| ORC3 | 9351 |
| ORC6 | 9019 |
| ORC4 | 8335 |
| E2F3 | 8287 |
| ORC5 | 5867 |
| E2F1 | 5718 |
| MCM8 | 4021 |
| ORC2 | 3375 |
| E2F2 | 2712 |
| ORC1 | 2398 |
| CDC6 | 1541 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| ORC3 | 9351 |
| ORC6 | 9019 |
| ORC4 | 8335 |
| E2F3 | 8287 |
| ORC5 | 5867 |
| E2F1 | 5718 |
| MCM8 | 4021 |
| ORC2 | 3375 |
| E2F2 | 2712 |
| ORC1 | 2398 |
| CDC6 | 1541 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] parallel stats4 stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] pkgload_1.1.0 GGally_2.0.0
## [3] beeswarm_0.2.3 gtools_3.8.2
## [5] echarts4r_0.3.2 mitch_1.0.4
## [7] MASS_7.3-51.6 fgsea_1.14.0
## [9] gplots_3.0.3 DESeq2_1.28.1
## [11] SummarizedExperiment_1.18.1 DelayedArray_0.14.0
## [13] matrixStats_0.56.0 Biobase_2.48.0
## [15] GenomicRanges_1.40.0 GenomeInfoDb_1.24.2
## [17] IRanges_2.22.2 S4Vectors_0.26.1
## [19] BiocGenerics_0.34.0 reshape2_1.4.4
## [21] forcats_0.5.0 stringr_1.4.0
## [23] dplyr_1.0.0 purrr_0.3.4
## [25] readr_1.3.1 tidyr_1.1.0
## [27] tibble_3.0.1 ggplot2_3.3.2
## [29] tidyverse_1.3.0
##
## loaded via a namespace (and not attached):
## [1] colorspace_1.4-1 ellipsis_0.3.1 rprojroot_1.3-2
## [4] XVector_0.28.0 fs_1.4.1 rstudioapi_0.11
## [7] farver_2.0.3 bit64_0.9-7 AnnotationDbi_1.50.0
## [10] fansi_0.4.1 lubridate_1.7.9 xml2_1.3.2
## [13] splines_4.0.2 geneplotter_1.66.0 knitr_1.28
## [16] jsonlite_1.6.1 broom_0.5.6 annotate_1.66.0
## [19] dbplyr_1.4.4 shiny_1.4.0.2 compiler_4.0.2
## [22] httr_1.4.1 backports_1.1.8 fastmap_1.0.1
## [25] assertthat_0.2.1 Matrix_1.2-18 cli_2.0.2
## [28] later_1.1.0.1 htmltools_0.5.0 tools_4.0.2
## [31] gtable_0.3.0 glue_1.4.1 GenomeInfoDbData_1.2.3
## [34] fastmatch_1.1-0 Rcpp_1.0.4.6 cellranger_1.1.0
## [37] vctrs_0.3.1 gdata_2.18.0 nlme_3.1-148
## [40] xfun_0.15 testthat_2.3.2 rvest_0.3.5
## [43] mime_0.9 lifecycle_0.2.0 XML_3.99-0.3
## [46] zlibbioc_1.34.0 scales_1.1.1 promises_1.1.1
## [49] hms_0.5.3 RColorBrewer_1.1-2 yaml_2.2.1
## [52] memoise_1.1.0 gridExtra_2.3 reshape_0.8.8
## [55] stringi_1.4.6 RSQLite_2.2.0 highr_0.8
## [58] genefilter_1.70.0 desc_1.2.0 caTools_1.18.0
## [61] BiocParallel_1.22.0 rlang_0.4.6 pkgconfig_2.0.3
## [64] bitops_1.0-6 evaluate_0.14 lattice_0.20-41
## [67] labeling_0.3 htmlwidgets_1.5.1 bit_1.1-15.2
## [70] tidyselect_1.1.0 plyr_1.8.6 magrittr_1.5
## [73] R6_2.4.1 generics_0.0.2 DBI_1.1.0
## [76] pillar_1.4.4 haven_2.3.1 withr_2.2.0
## [79] survival_3.2-3 RCurl_1.98-1.2 modelr_0.1.8
## [82] crayon_1.3.4 KernSmooth_2.23-17 rmarkdown_2.3
## [85] locfit_1.5-9.4 grid_4.0.2 readxl_1.3.1
## [88] data.table_1.12.8 blob_1.2.1 reprex_0.3.0
## [91] digest_0.6.25 pbmcapply_1.5.0 xtable_1.8-4
## [94] httpuv_1.5.4 munsell_0.5.0END of report