date generated: 2020-07-02

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                   x
## A1BG      2.6245484
## A1BG-AS1  0.4968992
## A1CF      0.5554787
## A2M      -3.2184650
## A2M-AS1  -3.0532140
## A2ML1    -0.3470803

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genesets 2400
num_genes_in_profile 21907
duplicated_genes_present 0
num_profile_genes_in_sets 8459
num_profile_genes_not_in_sets 13448

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2400
num_genesets_excluded 1036
num_genesets_included 1364

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 100 gene sets

set setSize pANOVA s.dist p.adjustANOVA
IRAK4 deficiency (TLR2/4) 10 8.80e-07 0.898 1.12e-05
MyD88 deficiency (TLR2/4) 10 8.80e-07 0.898 1.12e-05
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.31e-06 0.787 2.48e-05
alpha-linolenic acid (ALA) metabolism 12 2.31e-06 0.787 2.48e-05
Translocation of ZAP-70 to Immunological synapse 24 2.76e-10 -0.744 8.37e-09
Regulation of TLR by endogenous ligand 11 2.02e-05 0.742 1.48e-04
Hyaluronan uptake and degradation 12 9.15e-06 0.739 7.52e-05
Erythrocytes take up carbon dioxide and release oxygen 11 3.56e-05 0.720 2.40e-04
O2/CO2 exchange in erythrocytes 11 3.56e-05 0.720 2.40e-04
Uptake and function of anthrax toxins 10 1.13e-04 0.705 6.34e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 9.66e-05 0.679 5.59e-04
p130Cas linkage to MAPK signaling for integrins 11 1.39e-04 0.663 7.50e-04
Advanced glycosylation endproduct receptor signaling 12 9.45e-05 0.651 5.51e-04
Unwinding of DNA 12 1.04e-04 -0.647 5.98e-04
RNA Polymerase I Promoter Opening 19 2.76e-06 0.621 2.84e-05
RHO GTPases Activate WASPs and WAVEs 35 5.30e-10 0.606 1.54e-08
ROS and RNS production in phagocytes 31 7.98e-09 0.598 1.75e-07
Neutrophil degranulation 458 0.00e+00 0.585 5.00e-100
PD-1 signaling 28 1.17e-07 -0.578 1.97e-06
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 5.27e-04 0.578 2.40e-03
Insulin receptor recycling 21 6.66e-06 0.568 5.86e-05
Retrograde neurotrophin signalling 12 6.74e-04 0.567 2.92e-03
Signaling by Leptin 10 1.99e-03 0.565 7.21e-03
Dissolution of Fibrin Clot 12 7.34e-04 0.563 3.13e-03
Detoxification of Reactive Oxygen Species 32 3.93e-08 0.561 7.65e-07
COPI-independent Golgi-to-ER retrograde traffic 33 2.42e-08 0.561 5.00e-07
RHO GTPases Activate NADPH Oxidases 21 9.46e-06 0.558 7.68e-05
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 5.33e-04 0.555 2.41e-03
Platelet sensitization by LDL 16 1.33e-04 0.552 7.25e-04
Hyaluronan metabolism 15 2.23e-04 0.550 1.13e-03
Golgi Cisternae Pericentriolar Stack Reorganization 14 3.75e-04 0.549 1.78e-03
Phosphorylation of CD3 and TCR zeta chains 27 1.11e-06 -0.541 1.32e-05
RHO GTPases Activate ROCKs 18 7.25e-05 0.540 4.39e-04
Diseases associated with the TLR signaling cascade 23 8.58e-06 0.536 7.09e-05
Diseases of Immune System 23 8.58e-06 0.536 7.09e-05
IRAK1 recruits IKK complex 10 3.75e-03 0.529 1.21e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 3.75e-03 0.529 1.21e-02
DNA strand elongation 32 2.48e-07 -0.527 3.94e-06
Budding and maturation of HIV virion 26 3.43e-06 0.526 3.42e-05
Negative regulation of MET activity 18 1.12e-04 0.526 6.34e-04
MET activates RAP1 and RAC1 10 4.01e-03 0.525 1.28e-02
InlB-mediated entry of Listeria monocytogenes into host cell 12 1.63e-03 0.525 6.05e-03
DNA methylation 20 5.29e-05 0.522 3.42e-04
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 4.32e-03 0.521 1.34e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 29 1.26e-06 0.520 1.48e-05
Cargo concentration in the ER 30 8.85e-07 0.518 1.12e-05
MAP2K and MAPK activation 34 1.76e-07 0.517 2.82e-06
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 21 4.48e-05 0.514 2.94e-04
Neurodegenerative Diseases 21 4.48e-05 0.514 2.94e-04
VLDLR internalisation and degradation 12 2.22e-03 0.510 7.88e-03
Transferrin endocytosis and recycling 26 7.09e-06 0.509 6.16e-05
Gap junction trafficking 14 1.20e-03 0.500 4.76e-03
Platelet Adhesion to exposed collagen 13 1.83e-03 0.499 6.75e-03
EPHB-mediated forward signaling 32 1.02e-06 0.499 1.24e-05
Signaling by high-kinase activity BRAF mutants 31 1.54e-06 0.499 1.77e-05
Smooth Muscle Contraction 31 1.95e-06 0.494 2.15e-05
Pentose phosphate pathway 13 2.32e-03 0.488 8.17e-03
Activation of the pre-replicative complex 32 1.82e-06 -0.487 2.02e-05
Platelet Aggregation (Plug Formation) 28 8.14e-06 0.487 6.85e-05
RHO GTPases activate PAKs 20 1.79e-04 0.484 9.33e-04
RHO GTPases activate PKNs 48 6.59e-09 0.484 1.47e-07
Amyloid fiber formation 51 2.47e-09 0.483 5.83e-08
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 4.10e-03 0.478 1.30e-02
Diseases of hemostasis 12 4.10e-03 0.478 1.30e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 1.10e-04 0.476 6.24e-04
SHC1 events in EGFR signaling 12 4.43e-03 0.474 1.37e-02
Trafficking of GluR2-containing AMPA receptors 12 4.59e-03 0.472 1.41e-02
Spry regulation of FGF signaling 16 1.07e-03 0.472 4.28e-03
GRB2 events in EGFR signaling 11 6.79e-03 0.471 1.94e-02
Signaling by RAF1 mutants 34 1.98e-06 0.471 2.16e-05
Josephin domain DUBs 10 9.94e-03 0.471 2.60e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 7.01e-03 0.469 1.99e-02
Integrin signaling 22 1.39e-04 0.469 7.50e-04
Generation of second messenger molecules 38 7.90e-07 -0.463 1.05e-05
Antimicrobial peptides 33 4.52e-06 0.461 4.14e-05
Response of Mtb to phagocytosis 22 1.94e-04 0.459 9.93e-04
EGFR downregulation 27 3.88e-05 0.457 2.57e-04
GAB1 signalosome 15 2.21e-03 0.456 7.85e-03
Diseases of programmed cell death 23 1.53e-04 0.456 8.12e-04
The NLRP3 inflammasome 15 2.27e-03 0.455 8.01e-03
Response to elevated platelet cytosolic Ca2+ 110 1.59e-16 0.455 1.55e-14
activated TAK1 mediates p38 MAPK activation 19 6.06e-04 0.454 2.69e-03
Lagging Strand Synthesis 20 4.38e-04 -0.454 2.05e-03
Platelet degranulation 106 7.21e-16 0.453 6.56e-14
Packaging Of Telomere Ends 20 4.67e-04 0.452 2.18e-03
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 2.47e-03 0.451 8.56e-03
Prolonged ERK activation events 13 4.85e-03 0.451 1.47e-02
Mucopolysaccharidoses 11 9.95e-03 0.449 2.60e-02
WNT5A-dependent internalization of FZD4 13 5.11e-03 0.448 1.54e-02
Infection with Mycobacterium tuberculosis 26 7.67e-05 0.448 4.63e-04
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 1.52e-04 -0.447 8.08e-04
ATF6 (ATF6-alpha) activates chaperone genes 10 1.47e-02 0.446 3.53e-02
Membrane binding and targetting of GAG proteins 13 5.44e-03 0.445 1.61e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 5.44e-03 0.445 1.61e-02
Biotin transport and metabolism 11 1.07e-02 -0.444 2.77e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 3.67e-13 0.438 1.79e-11
Toll Like Receptor 2 (TLR2) Cascade 92 3.67e-13 0.438 1.79e-11
Toll Like Receptor TLR1:TLR2 Cascade 92 3.67e-13 0.438 1.79e-11
Toll Like Receptor TLR6:TLR2 Cascade 92 3.67e-13 0.438 1.79e-11
Suppression of phagosomal maturation 12 8.62e-03 0.438 2.36e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
IRAK4 deficiency (TLR2/4) 10 8.80e-07 0.898000 1.12e-05
MyD88 deficiency (TLR2/4) 10 8.80e-07 0.898000 1.12e-05
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.31e-06 0.787000 2.48e-05
alpha-linolenic acid (ALA) metabolism 12 2.31e-06 0.787000 2.48e-05
Translocation of ZAP-70 to Immunological synapse 24 2.76e-10 -0.744000 8.37e-09
Regulation of TLR by endogenous ligand 11 2.02e-05 0.742000 1.48e-04
Hyaluronan uptake and degradation 12 9.15e-06 0.739000 7.52e-05
Erythrocytes take up carbon dioxide and release oxygen 11 3.56e-05 0.720000 2.40e-04
O2/CO2 exchange in erythrocytes 11 3.56e-05 0.720000 2.40e-04
Uptake and function of anthrax toxins 10 1.13e-04 0.705000 6.34e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 9.66e-05 0.679000 5.59e-04
p130Cas linkage to MAPK signaling for integrins 11 1.39e-04 0.663000 7.50e-04
Advanced glycosylation endproduct receptor signaling 12 9.45e-05 0.651000 5.51e-04
Unwinding of DNA 12 1.04e-04 -0.647000 5.98e-04
RNA Polymerase I Promoter Opening 19 2.76e-06 0.621000 2.84e-05
RHO GTPases Activate WASPs and WAVEs 35 5.30e-10 0.606000 1.54e-08
ROS and RNS production in phagocytes 31 7.98e-09 0.598000 1.75e-07
Neutrophil degranulation 458 0.00e+00 0.585000 5.00e-100
PD-1 signaling 28 1.17e-07 -0.578000 1.97e-06
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 5.27e-04 0.578000 2.40e-03
Insulin receptor recycling 21 6.66e-06 0.568000 5.86e-05
Retrograde neurotrophin signalling 12 6.74e-04 0.567000 2.92e-03
Signaling by Leptin 10 1.99e-03 0.565000 7.21e-03
Dissolution of Fibrin Clot 12 7.34e-04 0.563000 3.13e-03
Detoxification of Reactive Oxygen Species 32 3.93e-08 0.561000 7.65e-07
COPI-independent Golgi-to-ER retrograde traffic 33 2.42e-08 0.561000 5.00e-07
RHO GTPases Activate NADPH Oxidases 21 9.46e-06 0.558000 7.68e-05
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 5.33e-04 0.555000 2.41e-03
Platelet sensitization by LDL 16 1.33e-04 0.552000 7.25e-04
Hyaluronan metabolism 15 2.23e-04 0.550000 1.13e-03
Golgi Cisternae Pericentriolar Stack Reorganization 14 3.75e-04 0.549000 1.78e-03
Phosphorylation of CD3 and TCR zeta chains 27 1.11e-06 -0.541000 1.32e-05
RHO GTPases Activate ROCKs 18 7.25e-05 0.540000 4.39e-04
Diseases associated with the TLR signaling cascade 23 8.58e-06 0.536000 7.09e-05
Diseases of Immune System 23 8.58e-06 0.536000 7.09e-05
IRAK1 recruits IKK complex 10 3.75e-03 0.529000 1.21e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 3.75e-03 0.529000 1.21e-02
DNA strand elongation 32 2.48e-07 -0.527000 3.94e-06
Budding and maturation of HIV virion 26 3.43e-06 0.526000 3.42e-05
Negative regulation of MET activity 18 1.12e-04 0.526000 6.34e-04
MET activates RAP1 and RAC1 10 4.01e-03 0.525000 1.28e-02
InlB-mediated entry of Listeria monocytogenes into host cell 12 1.63e-03 0.525000 6.05e-03
DNA methylation 20 5.29e-05 0.522000 3.42e-04
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 4.32e-03 0.521000 1.34e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 29 1.26e-06 0.520000 1.48e-05
Cargo concentration in the ER 30 8.85e-07 0.518000 1.12e-05
MAP2K and MAPK activation 34 1.76e-07 0.517000 2.82e-06
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 21 4.48e-05 0.514000 2.94e-04
Neurodegenerative Diseases 21 4.48e-05 0.514000 2.94e-04
VLDLR internalisation and degradation 12 2.22e-03 0.510000 7.88e-03
Transferrin endocytosis and recycling 26 7.09e-06 0.509000 6.16e-05
Gap junction trafficking 14 1.20e-03 0.500000 4.76e-03
Platelet Adhesion to exposed collagen 13 1.83e-03 0.499000 6.75e-03
EPHB-mediated forward signaling 32 1.02e-06 0.499000 1.24e-05
Signaling by high-kinase activity BRAF mutants 31 1.54e-06 0.499000 1.77e-05
Smooth Muscle Contraction 31 1.95e-06 0.494000 2.15e-05
Pentose phosphate pathway 13 2.32e-03 0.488000 8.17e-03
Activation of the pre-replicative complex 32 1.82e-06 -0.487000 2.02e-05
Platelet Aggregation (Plug Formation) 28 8.14e-06 0.487000 6.85e-05
RHO GTPases activate PAKs 20 1.79e-04 0.484000 9.33e-04
RHO GTPases activate PKNs 48 6.59e-09 0.484000 1.47e-07
Amyloid fiber formation 51 2.47e-09 0.483000 5.83e-08
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 4.10e-03 0.478000 1.30e-02
Diseases of hemostasis 12 4.10e-03 0.478000 1.30e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 1.10e-04 0.476000 6.24e-04
SHC1 events in EGFR signaling 12 4.43e-03 0.474000 1.37e-02
Trafficking of GluR2-containing AMPA receptors 12 4.59e-03 0.472000 1.41e-02
Spry regulation of FGF signaling 16 1.07e-03 0.472000 4.28e-03
GRB2 events in EGFR signaling 11 6.79e-03 0.471000 1.94e-02
Signaling by RAF1 mutants 34 1.98e-06 0.471000 2.16e-05
Josephin domain DUBs 10 9.94e-03 0.471000 2.60e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 7.01e-03 0.469000 1.99e-02
Integrin signaling 22 1.39e-04 0.469000 7.50e-04
Generation of second messenger molecules 38 7.90e-07 -0.463000 1.05e-05
Antimicrobial peptides 33 4.52e-06 0.461000 4.14e-05
Response of Mtb to phagocytosis 22 1.94e-04 0.459000 9.93e-04
EGFR downregulation 27 3.88e-05 0.457000 2.57e-04
GAB1 signalosome 15 2.21e-03 0.456000 7.85e-03
Diseases of programmed cell death 23 1.53e-04 0.456000 8.12e-04
The NLRP3 inflammasome 15 2.27e-03 0.455000 8.01e-03
Response to elevated platelet cytosolic Ca2+ 110 1.59e-16 0.455000 1.55e-14
activated TAK1 mediates p38 MAPK activation 19 6.06e-04 0.454000 2.69e-03
Lagging Strand Synthesis 20 4.38e-04 -0.454000 2.05e-03
Platelet degranulation 106 7.21e-16 0.453000 6.56e-14
Packaging Of Telomere Ends 20 4.67e-04 0.452000 2.18e-03
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 2.47e-03 0.451000 8.56e-03
Prolonged ERK activation events 13 4.85e-03 0.451000 1.47e-02
Mucopolysaccharidoses 11 9.95e-03 0.449000 2.60e-02
WNT5A-dependent internalization of FZD4 13 5.11e-03 0.448000 1.54e-02
Infection with Mycobacterium tuberculosis 26 7.67e-05 0.448000 4.63e-04
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 1.52e-04 -0.447000 8.08e-04
ATF6 (ATF6-alpha) activates chaperone genes 10 1.47e-02 0.446000 3.53e-02
Membrane binding and targetting of GAG proteins 13 5.44e-03 0.445000 1.61e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 5.44e-03 0.445000 1.61e-02
Biotin transport and metabolism 11 1.07e-02 -0.444000 2.77e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 3.67e-13 0.438000 1.79e-11
Toll Like Receptor 2 (TLR2) Cascade 92 3.67e-13 0.438000 1.79e-11
Toll Like Receptor TLR1:TLR2 Cascade 92 3.67e-13 0.438000 1.79e-11
Toll Like Receptor TLR6:TLR2 Cascade 92 3.67e-13 0.438000 1.79e-11
Suppression of phagosomal maturation 12 8.62e-03 0.438000 2.36e-02
Signal amplification 28 6.14e-05 0.437000 3.86e-04
Signal transduction by L1 20 7.32e-04 0.436000 3.13e-03
Alpha-protein kinase 1 signaling pathway 11 1.24e-02 0.435000 3.11e-02
Processive synthesis on the lagging strand 15 3.73e-03 -0.433000 1.21e-02
ERKs are inactivated 13 7.00e-03 0.432000 1.99e-02
Paradoxical activation of RAF signaling by kinase inactive BRAF 38 4.07e-06 0.432000 3.80e-05
Signaling by RAS mutants 38 4.07e-06 0.432000 3.80e-05
Signaling by moderate kinase activity BRAF mutants 38 4.07e-06 0.432000 3.80e-05
Signaling downstream of RAS mutants 38 4.07e-06 0.432000 3.80e-05
Sealing of the nuclear envelope (NE) by ESCRT-III 25 1.87e-04 0.432000 9.72e-04
RHO GTPases activate IQGAPs 11 1.36e-02 0.430000 3.35e-02
HDR through MMEJ (alt-NHEJ) 10 1.86e-02 -0.430000 4.30e-02
Formation of ATP by chemiosmotic coupling 18 1.67e-03 0.428000 6.20e-03
Activation of ATR in response to replication stress 37 6.89e-06 -0.427000 6.03e-05
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 1.42e-02 0.427000 3.45e-02
AKT phosphorylates targets in the cytosol 14 5.96e-03 0.424000 1.75e-02
Transcriptional regulation of granulopoiesis 46 6.81e-07 0.423000 9.48e-06
Recycling pathway of L1 26 1.89e-04 0.423000 9.77e-04
Butyrophilin (BTN) family interactions 10 2.07e-02 -0.423000 4.71e-02
Late endosomal microautophagy 30 6.24e-05 0.422000 3.89e-04
PCNA-Dependent Long Patch Base Excision Repair 21 8.10e-04 -0.422000 3.38e-03
Interleukin-1 signaling 98 6.36e-13 0.420000 2.89e-11
Growth hormone receptor signaling 20 1.22e-03 0.418000 4.77e-03
Glycogen breakdown (glycogenolysis) 13 9.17e-03 0.417000 2.47e-02
Erythropoietin activates RAS 13 9.25e-03 0.417000 2.48e-02
Assembly Of The HIV Virion 15 5.22e-03 0.416000 1.56e-02
Collagen degradation 28 1.40e-04 0.416000 7.50e-04
ATF6 (ATF6-alpha) activates chaperones 12 1.27e-02 0.416000 3.15e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 88 1.75e-11 0.415000 6.45e-10
Regulated proteolysis of p75NTR 11 1.74e-02 0.414000 4.08e-02
SUMOylation of immune response proteins 11 1.81e-02 0.412000 4.18e-02
Pre-NOTCH Processing in Golgi 18 2.56e-03 0.411000 8.82e-03
Signal regulatory protein family interactions 12 1.38e-02 0.411000 3.39e-02
Notch-HLH transcription pathway 28 1.72e-04 0.410000 9.03e-04
Gastrin-CREB signalling pathway via PKC and MAPK 14 8.03e-03 0.409000 2.22e-02
ERK/MAPK targets 22 9.27e-04 0.408000 3.79e-03
HuR (ELAVL1) binds and stabilizes mRNA 10 2.60e-02 0.407000 5.73e-02
DARPP-32 events 22 9.93e-04 0.405000 4.01e-03
Glycogen synthesis 13 1.15e-02 0.405000 2.92e-02
Removal of the Flap Intermediate 14 8.85e-03 -0.404000 2.40e-02
Lysosome Vesicle Biogenesis 32 7.71e-05 0.404000 4.63e-04
HSP90 chaperone cycle for steroid hormone receptors (SHR) 36 2.82e-05 0.403000 1.97e-04
ADP signalling through P2Y purinoceptor 1 21 1.41e-03 0.402000 5.40e-03
MyD88 dependent cascade initiated on endosome 89 5.33e-11 0.402000 1.73e-09
Toll Like Receptor 7/8 (TLR7/8) Cascade 89 5.33e-11 0.402000 1.73e-09
Inflammasomes 20 1.92e-03 0.401000 7.00e-03
Signalling to ERKs 32 8.82e-05 0.400000 5.23e-04
Interleukin-6 signaling 10 2.91e-02 0.398000 6.32e-02
Toll Like Receptor 4 (TLR4) Cascade 121 4.08e-14 0.398000 2.65e-12
Heme degradation 10 2.97e-02 0.397000 6.43e-02
rRNA modification in the nucleus and cytosol 59 1.46e-07 -0.396000 2.42e-06
MyD88 cascade initiated on plasma membrane 82 6.02e-10 0.395000 1.61e-08
Toll Like Receptor 10 (TLR10) Cascade 82 6.02e-10 0.395000 1.61e-08
Toll Like Receptor 5 (TLR5) Cascade 82 6.02e-10 0.395000 1.61e-08
EPH-Ephrin signaling 79 1.33e-09 0.394000 3.43e-08
Activation of the AP-1 family of transcription factors 10 3.10e-02 0.394000 6.61e-02
RHO GTPases activate KTN1 11 2.38e-02 0.394000 5.32e-02
Regulation of IFNG signaling 14 1.11e-02 0.392000 2.84e-02
Antigen processing-Cross presentation 98 2.10e-11 0.391000 7.55e-10
COPI-mediated anterograde transport 78 2.39e-09 0.391000 5.83e-08
Signaling by BRAF and RAF fusions 57 3.58e-07 0.390000 5.43e-06
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 2.21e-04 0.390000 1.12e-03
Toll Like Receptor 9 (TLR9) Cascade 93 9.72e-11 0.388000 3.08e-09
Translation of Replicase and Assembly of the Replication Transcription Complex 12 2.00e-02 0.388000 4.58e-02
COPII-mediated vesicle transport 65 6.58e-08 0.387000 1.17e-06
Apoptosis induced DNA fragmentation 10 3.40e-02 0.387000 7.14e-02
Telomere C-strand (Lagging Strand) Synthesis 34 9.52e-05 -0.387000 5.53e-04
Energy dependent regulation of mTOR by LKB1-AMPK 27 5.19e-04 0.386000 2.38e-03
Formation of apoptosome 11 2.75e-02 0.384000 6.00e-02
Regulation of the apoptosome activity 11 2.75e-02 0.384000 6.00e-02
Toll-like Receptor Cascades 143 3.06e-15 0.382000 2.61e-13
Sema4D in semaphorin signaling 22 2.10e-03 0.379000 7.51e-03
Common Pathway of Fibrin Clot Formation 14 1.42e-02 0.378000 3.45e-02
LDL clearance 18 5.50e-03 0.378000 1.62e-02
Cross-presentation of soluble exogenous antigens (endosomes) 48 5.93e-06 0.378000 5.29e-05
Frs2-mediated activation 11 3.04e-02 0.377000 6.52e-02
Formation of the cornified envelope 21 2.87e-03 0.376000 9.71e-03
Signaling by Erythropoietin 24 1.44e-03 0.376000 5.49e-03
Sema4D induced cell migration and growth-cone collapse 19 4.60e-03 0.376000 1.41e-02
Iron uptake and transport 52 2.91e-06 0.375000 2.96e-05
Cellular response to hypoxia 72 3.91e-08 0.374000 7.65e-07
ADP signalling through P2Y purinoceptor 12 18 5.98e-03 0.374000 1.75e-02
G-protein beta:gamma signalling 29 5.02e-04 0.373000 2.31e-03
mTORC1-mediated signalling 23 2.02e-03 0.372000 7.29e-03
trans-Golgi Network Vesicle Budding 69 9.74e-08 0.371000 1.66e-06
Thromboxane signalling through TP receptor 20 4.13e-03 0.370000 1.30e-02
ER to Golgi Anterograde Transport 129 4.27e-13 0.369000 2.01e-11
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 54 2.74e-06 0.369000 2.84e-05
Innate Immune System 968 8.43e-85 0.369000 5.75e-82
Signaling by NTRK1 (TRKA) 101 1.65e-10 0.368000 5.11e-09
Golgi Associated Vesicle Biogenesis 55 2.37e-06 0.368000 2.52e-05
Cell-extracellular matrix interactions 14 1.73e-02 0.367000 4.07e-02
RHO GTPases activate CIT 18 6.98e-03 0.367000 1.99e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 2.90e-03 0.367000 9.78e-03
Regulation of ornithine decarboxylase (ODC) 50 7.19e-06 0.367000 6.21e-05
Leading Strand Synthesis 14 1.75e-02 -0.367000 4.09e-02
Polymerase switching 14 1.75e-02 -0.367000 4.09e-02
Diseases of DNA repair 10 4.46e-02 -0.367000 9.00e-02
MAP kinase activation 63 5.02e-07 0.366000 7.14e-06
Response of EIF2AK1 (HRI) to heme deficiency 14 1.77e-02 0.366000 4.12e-02
Beta-catenin phosphorylation cascade 17 9.00e-03 0.366000 2.44e-02
Signaling by MET 61 7.70e-07 0.366000 1.03e-05
Acyl chain remodelling of PI 10 4.53e-02 0.366000 9.09e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.15e-02 0.365000 2.92e-02
Gap junction trafficking and regulation 16 1.15e-02 0.365000 2.93e-02
RAF activation 32 3.61e-04 0.364000 1.73e-03
Signaling by NTRKs 116 1.21e-11 0.364000 4.60e-10
Platelet activation, signaling and aggregation 221 1.26e-20 0.363000 1.71e-18
Calnexin/calreticulin cycle 26 1.36e-03 0.363000 5.23e-03
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 1.20e-02 0.363000 3.03e-02
Cell recruitment (pro-inflammatory response) 22 3.24e-03 0.363000 1.08e-02
Purinergic signaling in leishmaniasis infection 22 3.24e-03 0.363000 1.08e-02
Glycogen metabolism 23 2.70e-03 0.361000 9.17e-03
Telomere C-strand synthesis initiation 13 2.51e-02 -0.359000 5.55e-02
Endogenous sterols 17 1.05e-02 0.358000 2.72e-02
HDACs deacetylate histones 47 2.13e-05 0.358000 1.54e-04
Pexophagy 11 3.97e-02 0.358000 8.12e-02
Clathrin-mediated endocytosis 127 3.18e-12 0.358000 1.32e-10
Regulation of activated PAK-2p34 by proteasome mediated degradation 49 1.49e-05 0.358000 1.15e-04
RAB geranylgeranylation 61 1.40e-06 0.357000 1.62e-05
Cleavage of the damaged purine 24 2.47e-03 0.357000 8.56e-03
Depurination 24 2.47e-03 0.357000 8.56e-03
Recognition and association of DNA glycosylase with site containing an affected purine 24 2.47e-03 0.357000 8.56e-03
IKK complex recruitment mediated by RIP1 23 3.06e-03 0.357000 1.03e-02
Homologous DNA Pairing and Strand Exchange 42 6.53e-05 -0.356000 4.02e-04
Fanconi Anemia Pathway 36 2.19e-04 -0.356000 1.12e-03
Pre-NOTCH Transcription and Translation 49 1.63e-05 0.356000 1.23e-04
MET activates RAS signaling 10 5.14e-02 0.356000 1.01e-01
G beta:gamma signalling through CDC42 17 1.12e-02 0.355000 2.86e-02
MTOR signalling 38 1.59e-04 0.354000 8.35e-04
ER-Phagosome pathway 83 2.45e-08 0.354000 5.00e-07
Post-translational protein phosphorylation 70 3.12e-07 0.354000 4.90e-06
GP1b-IX-V activation signalling 10 5.30e-02 0.353000 1.03e-01
Metabolism of Angiotensinogen to Angiotensins 11 4.29e-02 0.353000 8.73e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 65 8.91e-07 0.352000 1.12e-05
Thrombin signalling through proteinase activated receptors (PARs) 27 1.53e-03 0.352000 5.76e-03
Negative regulation of NOTCH4 signaling 54 7.75e-06 0.352000 6.61e-05
Interleukin-1 family signaling 125 1.10e-11 0.352000 4.29e-10
Pre-NOTCH Expression and Processing 65 1.01e-06 0.351000 1.24e-05
MAPK targets/ Nuclear events mediated by MAP kinases 31 7.39e-04 0.350000 3.14e-03
Defective CFTR causes cystic fibrosis 60 2.77e-06 0.350000 2.84e-05
Hh mutants abrogate ligand secretion 55 7.36e-06 0.349000 6.32e-05
Resolution of Abasic Sites (AP sites) 37 2.42e-04 -0.349000 1.22e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA 54 9.55e-06 0.348000 7.71e-05
Syndecan interactions 19 8.61e-03 0.348000 2.36e-02
Activation of Matrix Metalloproteinases 23 3.96e-03 0.347000 1.26e-02
Nucleobase biosynthesis 13 3.03e-02 -0.347000 6.52e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs 83 4.63e-08 0.347000 8.64e-07
Inhibition of DNA recombination at telomere 35 4.03e-04 0.346000 1.90e-03
PKA activation in glucagon signalling 14 2.54e-02 0.345000 5.61e-02
Degradation of DVL 55 1.09e-05 0.343000 8.56e-05
Signaling by EGFR in Cancer 23 4.50e-03 0.342000 1.38e-02
Cytochrome c-mediated apoptotic response 13 3.32e-02 0.341000 7.02e-02
Vif-mediated degradation of APOBEC3G 53 1.85e-05 0.340000 1.38e-04
Pyrimidine salvage 10 6.27e-02 0.340000 1.17e-01
Hedgehog ligand biogenesis 59 6.36e-06 0.340000 5.63e-05
MyD88-independent TLR4 cascade 96 8.80e-09 0.340000 1.88e-07
TRIF(TICAM1)-mediated TLR4 signaling 96 8.80e-09 0.340000 1.88e-07
Regulation of Apoptosis 52 2.40e-05 0.339000 1.71e-04
Translocation of SLC2A4 (GLUT4) to the plasma membrane 48 5.15e-05 0.338000 3.36e-04
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 27 2.40e-03 0.337000 8.41e-03
G beta:gamma signalling through PLC beta 17 1.61e-02 0.337000 3.82e-02
Rev-mediated nuclear export of HIV RNA 35 5.73e-04 -0.336000 2.57e-03
Interleukin-17 signaling 68 1.63e-06 0.336000 1.84e-05
Cargo recognition for clathrin-mediated endocytosis 90 4.62e-08 0.333000 8.64e-07
Oncogenic MAPK signaling 73 8.66e-07 0.333000 1.12e-05
Degradation of GLI2 by the proteasome 57 1.40e-05 0.333000 1.08e-04
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 2.81e-05 0.332000 1.97e-04
Negative regulation of FGFR3 signaling 20 1.00e-02 0.332000 2.62e-02
FOXO-mediated transcription of cell death genes 16 2.16e-02 0.332000 4.88e-02
SHC1 events in ERBB4 signaling 10 6.97e-02 0.331000 1.29e-01
Diseases of carbohydrate metabolism 29 2.03e-03 0.331000 7.29e-03
Glucagon signaling in metabolic regulation 27 2.92e-03 0.331000 9.85e-03
ER Quality Control Compartment (ERQC) 21 8.78e-03 0.330000 2.39e-02
Golgi-to-ER retrograde transport 111 1.85e-09 0.330000 4.68e-08
Presynaptic phase of homologous DNA pairing and strand exchange 39 3.62e-04 -0.330000 1.73e-03
Signaling by EGFR 46 1.08e-04 0.330000 6.18e-04
GPVI-mediated activation cascade 31 1.52e-03 0.329000 5.73e-03
Interactions of Rev with host cellular proteins 37 5.34e-04 -0.329000 2.41e-03
Degradation of GLI1 by the proteasome 58 1.55e-05 0.328000 1.17e-04
Regulation of PTEN stability and activity 67 3.65e-06 0.327000 3.55e-05
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 51 5.44e-05 0.327000 3.45e-04
p53-Independent DNA Damage Response 51 5.44e-05 0.327000 3.45e-04
p53-Independent G1/S DNA damage checkpoint 51 5.44e-05 0.327000 3.45e-04
Rap1 signalling 13 4.20e-02 0.326000 8.56e-02
VxPx cargo-targeting to cilium 19 1.42e-02 0.325000 3.45e-02
E3 ubiquitin ligases ubiquitinate target proteins 52 5.18e-05 0.324000 3.37e-04
Vpu mediated degradation of CD4 51 6.53e-05 0.323000 4.02e-04
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.56e-03 -0.323000 5.85e-03
NIK-->noncanonical NF-kB signaling 58 2.09e-05 0.323000 1.52e-04
RAB GEFs exchange GTP for GDP on RABs 88 1.64e-07 0.323000 2.70e-06
G-protein activation 23 7.43e-03 0.322000 2.09e-02
Signaling by NOTCH4 79 7.25e-07 0.322000 9.79e-06
Synthesis of PC 23 7.57e-03 0.322000 2.12e-02
Nuclear Events (kinase and transcription factor activation) 53 5.73e-05 0.319000 3.62e-04
Protein ubiquitination 72 2.97e-06 0.318000 3.00e-05
G beta:gamma signalling through BTK 15 3.29e-02 0.318000 6.97e-02
Triglyceride catabolism 16 2.79e-02 0.318000 6.05e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 29 3.13e-03 0.317000 1.05e-02
Dectin-1 mediated noncanonical NF-kB signaling 59 2.55e-05 0.317000 1.81e-04
GLI3 is processed to GLI3R by the proteasome 58 3.11e-05 0.316000 2.15e-04
Amino acids regulate mTORC1 50 1.10e-04 0.316000 6.24e-04
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 80 1.02e-06 0.316000 1.24e-05
TNFR1-induced proapoptotic signaling 12 5.80e-02 -0.316000 1.11e-01
ERBB2 Regulates Cell Motility 10 8.42e-02 0.315000 1.50e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 2.80e-05 0.315000 1.97e-04
Nucleotide salvage 21 1.26e-02 0.315000 3.14e-02
Metabolism of polyamines 58 3.44e-05 0.314000 2.35e-04
Ubiquitin-dependent degradation of Cyclin D 51 1.07e-04 0.313000 6.14e-04
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.33e-03 0.313000 5.14e-03
Apoptotic factor-mediated response 18 2.15e-02 0.313000 4.86e-02
Extension of Telomeres 51 1.15e-04 -0.312000 6.36e-04
Signaling by NOTCH 183 3.32e-13 0.312000 1.79e-11
Transport to the Golgi and subsequent modification 155 2.18e-11 0.311000 7.63e-10
Metabolism of steroid hormones 21 1.35e-02 0.311000 3.35e-02
RORA activates gene expression 18 2.24e-02 0.311000 5.03e-02
Vpr-mediated nuclear import of PICs 34 1.72e-03 -0.311000 6.37e-03
Uptake and actions of bacterial toxins 27 5.22e-03 0.311000 1.56e-02
Negative regulation of FGFR4 signaling 21 1.39e-02 0.310000 3.41e-02
Autophagy 124 2.60e-09 0.310000 6.02e-08
Activation of BAD and translocation to mitochondria 15 3.80e-02 0.309000 7.84e-02
Formation of Fibrin Clot (Clotting Cascade) 26 6.35e-03 0.309000 1.84e-02
Membrane Trafficking 559 7.39e-36 0.309000 2.52e-33
Mitochondrial tRNA aminoacylation 21 1.45e-02 -0.308000 3.50e-02
Nuclear import of Rev protein 34 1.88e-03 -0.308000 6.91e-03
rRNA processing in the nucleus and cytosol 190 2.49e-13 -0.308000 1.48e-11
NS1 Mediated Effects on Host Pathways 40 7.65e-04 -0.307000 3.23e-03
Metabolism of porphyrins 22 1.26e-02 0.307000 3.15e-02
Major pathway of rRNA processing in the nucleolus and cytosol 180 1.17e-12 -0.307000 5.16e-11
Condensation of Prophase Chromosomes 29 4.30e-03 0.306000 1.34e-02
Presynaptic function of Kainate receptors 18 2.45e-02 0.306000 5.45e-02
Effects of PIP2 hydrolysis 24 9.50e-03 -0.306000 2.54e-02
Plasma lipoprotein clearance 29 4.39e-03 0.306000 1.36e-02
ABC transporter disorders 71 8.47e-06 0.306000 7.09e-05
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 4.79e-02 -0.305000 9.52e-02
Regulation of RUNX3 expression and activity 55 8.98e-05 0.305000 5.30e-04
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 4.48e-03 0.305000 1.38e-02
Polymerase switching on the C-strand of the telomere 26 7.18e-03 -0.305000 2.03e-02
cGMP effects 13 5.75e-02 0.304000 1.10e-01
VEGFA-VEGFR2 Pathway 92 4.79e-07 0.304000 6.88e-06
L1CAM interactions 85 1.30e-06 0.304000 1.52e-05
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 3.55e-02 0.304000 7.39e-02
Glycogen storage diseases 13 5.87e-02 0.303000 1.11e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 8.79e-03 0.303000 2.39e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 1.40e-02 0.303000 3.43e-02
Trafficking and processing of endosomal TLR 13 5.96e-02 0.302000 1.13e-01
Senescence-Associated Secretory Phenotype (SASP) 66 2.37e-05 0.301000 1.70e-04
Selenocysteine synthesis 92 6.15e-07 -0.301000 8.64e-06
CLEC7A (Dectin-1) signaling 97 3.39e-07 0.300000 5.20e-06
Translesion synthesis by REV1 16 3.85e-02 -0.299000 7.93e-02
Toll Like Receptor 3 (TLR3) Cascade 92 7.25e-07 0.299000 9.79e-06
Negative regulation of FGFR1 signaling 24 1.14e-02 0.298000 2.92e-02
Autodegradation of the E3 ubiquitin ligase COP1 50 2.66e-04 0.298000 1.34e-03
Activation of G protein gated Potassium channels 20 2.12e-02 0.298000 4.79e-02
G protein gated Potassium channels 20 2.12e-02 0.298000 4.79e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 2.12e-02 0.298000 4.79e-02
CD28 dependent PI3K/Akt signaling 22 1.60e-02 -0.297000 3.81e-02
PCP/CE pathway 87 1.77e-06 0.296000 1.98e-05
p38MAPK events 13 6.44e-02 0.296000 1.20e-01
Signaling by Insulin receptor 59 9.22e-05 0.294000 5.42e-04
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 6.69e-02 0.294000 1.24e-01
MET promotes cell motility 26 9.58e-03 0.294000 2.54e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 3.62e-02 0.293000 7.50e-02
Diseases associated with glycosylation precursor biosynthesis 18 3.11e-02 0.293000 6.63e-02
p75NTR signals via NF-kB 15 4.92e-02 0.293000 9.76e-02
Activation of NF-kappaB in B cells 66 3.79e-05 0.293000 2.54e-04
Chondroitin sulfate biosynthesis 12 7.95e-02 0.292000 1.44e-01
Biosynthesis of specialized proresolving mediators (SPMs) 16 4.33e-02 0.292000 8.78e-02
Aquaporin-mediated transport 38 1.87e-03 0.292000 6.86e-03
TBC/RABGAPs 45 7.53e-04 0.290000 3.19e-03
Constitutive Signaling by EGFRvIII 14 6.00e-02 0.290000 1.13e-01
Signaling by EGFRvIII in Cancer 14 6.00e-02 0.290000 1.13e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.47e-03 0.290000 1.14e-02
tRNA processing in the nucleus 59 1.20e-04 -0.290000 6.60e-04
Integration of energy metabolism 86 3.48e-06 0.289000 3.44e-05
MASTL Facilitates Mitotic Progression 10 1.13e-01 0.289000 1.87e-01
Interleukin-4 and Interleukin-13 signaling 92 1.63e-06 0.289000 1.84e-05
Transport of Ribonucleoproteins into the Host Nucleus 32 4.64e-03 -0.289000 1.42e-02
rRNA processing 219 1.68e-13 -0.289000 1.04e-11
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 51 3.62e-04 0.289000 1.73e-03
Opioid Signalling 75 1.55e-05 0.289000 1.17e-04
Misspliced GSK3beta mutants stabilize beta-catenin 15 5.33e-02 0.288000 1.03e-01
S33 mutants of beta-catenin aren't phosphorylated 15 5.33e-02 0.288000 1.03e-01
S37 mutants of beta-catenin aren't phosphorylated 15 5.33e-02 0.288000 1.03e-01
S45 mutants of beta-catenin aren't phosphorylated 15 5.33e-02 0.288000 1.03e-01
T41 mutants of beta-catenin aren't phosphorylated 15 5.33e-02 0.288000 1.03e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 5.33e-02 0.288000 1.03e-01
Prefoldin mediated transfer of substrate to CCT/TriC 26 1.11e-02 0.288000 2.84e-02
Formation of tubulin folding intermediates by CCT/TriC 22 1.97e-02 0.287000 4.53e-02
Export of Viral Ribonucleoproteins from Nucleus 33 4.35e-03 -0.287000 1.35e-02
Interactions of Vpr with host cellular proteins 37 2.58e-03 -0.286000 8.88e-03
Interferon alpha/beta signaling 57 1.86e-04 -0.286000 9.67e-04
Receptor Mediated Mitophagy 11 1.01e-01 0.286000 1.71e-01
SCF-beta-TrCP mediated degradation of Emi1 54 2.84e-04 0.285000 1.41e-03
Signaling by PDGFRA extracellular domain mutants 12 8.72e-02 0.285000 1.53e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 8.72e-02 0.285000 1.53e-01
G beta:gamma signalling through PI3Kgamma 22 2.10e-02 0.284000 4.79e-02
Signalling to RAS 19 3.23e-02 0.284000 6.86e-02
SIRT1 negatively regulates rRNA expression 24 1.62e-02 0.284000 3.85e-02
Carnitine metabolism 10 1.21e-01 0.283000 1.97e-01
Peptide chain elongation 88 4.47e-06 -0.283000 4.12e-05
Regulation of mRNA stability by proteins that bind AU-rich elements 88 4.60e-06 0.283000 4.19e-05
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 5.85e-02 0.282000 1.11e-01
EPHA-mediated growth cone collapse 13 7.87e-02 0.282000 1.42e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 9.17e-02 0.281000 1.60e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 3.91e-02 0.281000 8.03e-02
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 3.91e-02 0.281000 8.03e-02
Signaling by Non-Receptor Tyrosine Kinases 48 8.02e-04 0.280000 3.35e-03
Signaling by PTK6 48 8.02e-04 0.280000 3.35e-03
Post-chaperonin tubulin folding pathway 19 3.49e-02 0.280000 7.27e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 6.24e-03 0.279000 1.82e-02
Interleukin-27 signaling 11 1.09e-01 0.279000 1.82e-01
HDR through Single Strand Annealing (SSA) 37 3.31e-03 -0.279000 1.09e-02
NOTCH1 Intracellular Domain Regulates Transcription 45 1.21e-03 0.279000 4.77e-03
TICAM1,TRAF6-dependent induction of TAK1 complex 11 1.10e-01 0.278000 1.83e-01
SHC1 events in ERBB2 signaling 17 4.72e-02 0.278000 9.42e-02
Cleavage of the damaged pyrimidine 29 9.60e-03 0.278000 2.54e-02
Depyrimidination 29 9.60e-03 0.278000 2.54e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 9.60e-03 0.278000 2.54e-02
XBP1(S) activates chaperone genes 47 9.85e-04 0.278000 3.99e-03
Beta-oxidation of very long chain fatty acids 10 1.32e-01 0.275000 2.11e-01
Rab regulation of trafficking 121 1.71e-07 0.275000 2.77e-06
Autodegradation of Cdh1 by Cdh1:APC/C 64 1.44e-04 0.275000 7.72e-04
Asparagine N-linked glycosylation 269 8.72e-15 0.275000 6.99e-13
Eukaryotic Translation Elongation 93 4.78e-06 -0.274000 4.32e-05
Mitotic Telophase/Cytokinesis 13 8.70e-02 0.274000 1.53e-01
Myogenesis 21 2.98e-02 0.274000 6.43e-02
Degradation of AXIN 54 5.06e-04 0.274000 2.32e-03
TRAF6 mediated NF-kB activation 23 2.36e-02 0.273000 5.28e-02
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 1.17e-01 -0.273000 1.93e-01
TGF-beta receptor signaling activates SMADs 32 7.63e-03 0.273000 2.14e-02
G alpha (z) signalling events 36 4.66e-03 0.272000 1.42e-02
Transport of the SLBP independent Mature mRNA 35 5.34e-03 -0.272000 1.59e-02
PLC beta mediated events 43 2.03e-03 0.272000 7.30e-03
Oxidative Stress Induced Senescence 79 2.96e-05 0.272000 2.05e-04
Platelet homeostasis 70 8.49e-05 0.272000 5.08e-04
Signaling by NOTCH1 67 1.22e-04 0.271000 6.68e-04
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 7.94e-03 -0.271000 2.20e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 7.94e-03 -0.271000 2.20e-02
Vesicle-mediated transport 650 3.62e-32 0.271000 9.87e-30
Macroautophagy 110 9.07e-07 0.271000 1.12e-05
Signaling by FGFR3 31 9.03e-03 0.271000 2.44e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 179 5.47e-10 0.269000 1.56e-08
tRNA modification in the nucleus and cytosol 43 2.34e-03 -0.268000 8.23e-03
Stabilization of p53 55 5.81e-04 0.268000 2.60e-03
Signaling by VEGF 100 3.61e-06 0.268000 3.54e-05
Activation of GABAB receptors 31 9.83e-03 0.268000 2.58e-02
GABA B receptor activation 31 9.83e-03 0.268000 2.58e-02
Signaling by Interleukins 386 1.86e-19 0.267000 2.30e-17
IRE1alpha activates chaperones 49 1.21e-03 0.267000 4.77e-03
Acyl chain remodelling of PC 19 4.38e-02 0.267000 8.86e-02
PKA activation 15 7.33e-02 0.267000 1.34e-01
Signaling by Receptor Tyrosine Kinases 414 1.08e-20 0.267000 1.63e-18
Metalloprotease DUBs 21 3.43e-02 0.267000 7.18e-02
Citric acid cycle (TCA cycle) 22 3.04e-02 0.267000 6.52e-02
NF-kB is activated and signals survival 12 1.10e-01 0.267000 1.83e-01
Apoptosis 168 2.48e-09 0.267000 5.83e-08
PPARA activates gene expression 104 2.67e-06 0.266000 2.80e-05
Intrinsic Pathway of Fibrin Clot Formation 16 6.51e-02 0.266000 1.21e-01
Respiratory electron transport 101 3.84e-06 0.266000 3.71e-05
Activated NOTCH1 Transmits Signal to the Nucleus 27 1.69e-02 0.266000 3.99e-02
Eukaryotic Translation Termination 92 1.07e-05 -0.266000 8.47e-05
Translesion synthesis by POLI 17 5.83e-02 -0.265000 1.11e-01
Plasma lipoprotein assembly, remodeling, and clearance 53 8.44e-04 0.265000 3.51e-03
Programmed Cell Death 171 2.39e-09 0.264000 5.83e-08
Postmitotic nuclear pore complex (NPC) reformation 27 1.76e-02 -0.264000 4.11e-02
Viral mRNA Translation 88 1.91e-05 -0.264000 1.41e-04
Amine ligand-binding receptors 10 1.49e-01 -0.264000 2.35e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 6.24e-03 0.263000 1.82e-02
Cristae formation 31 1.11e-02 0.263000 2.85e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 124 4.08e-07 0.263000 5.92e-06
MAPK6/MAPK4 signaling 83 3.44e-05 0.263000 2.35e-04
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.63e-02 -0.262000 3.88e-02
Signaling by SCF-KIT 40 4.19e-03 0.262000 1.32e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 3.06e-02 0.260000 6.55e-02
Scavenging by Class A Receptors 12 1.21e-01 0.259000 1.97e-01
Tie2 Signaling 16 7.32e-02 0.259000 1.34e-01
C-type lectin receptors (CLRs) 129 4.08e-07 0.258000 5.92e-06
Prostacyclin signalling through prostacyclin receptor 16 7.42e-02 0.258000 1.36e-01
Purine ribonucleoside monophosphate biosynthesis 10 1.58e-01 -0.258000 2.47e-01
AMER1 mutants destabilize the destruction complex 14 9.52e-02 0.258000 1.64e-01
APC truncation mutants have impaired AXIN binding 14 9.52e-02 0.258000 1.64e-01
AXIN missense mutants destabilize the destruction complex 14 9.52e-02 0.258000 1.64e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 9.52e-02 0.258000 1.64e-01
Truncations of AMER1 destabilize the destruction complex 14 9.52e-02 0.258000 1.64e-01
truncated APC mutants destabilize the destruction complex 14 9.52e-02 0.258000 1.64e-01
Regulation of signaling by CBL 18 5.86e-02 0.257000 1.11e-01
Interleukin-10 signaling 35 8.52e-03 0.257000 2.34e-02
Metabolism of non-coding RNA 53 1.23e-03 -0.257000 4.77e-03
snRNP Assembly 53 1.23e-03 -0.257000 4.77e-03
Regulation of insulin secretion 60 5.84e-04 0.257000 2.60e-03
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 53 1.23e-03 0.257000 4.77e-03
Mitochondrial iron-sulfur cluster biogenesis 13 1.09e-01 0.257000 1.82e-01
Signaling by FGFR4 31 1.35e-02 0.256000 3.34e-02
Potential therapeutics for SARS 36 7.80e-03 0.256000 2.18e-02
Hedgehog 'on' state 76 1.13e-04 0.256000 6.34e-04
GABA receptor activation 36 7.86e-03 0.256000 2.19e-02
Caspase activation via Death Receptors in the presence of ligand 16 7.63e-02 0.256000 1.39e-01
APC/C:Cdc20 mediated degradation of Securin 67 2.91e-04 0.256000 1.44e-03
Base-Excision Repair, AP Site Formation 31 1.37e-02 0.256000 3.37e-02
Intraflagellar transport 39 5.71e-03 -0.256000 1.68e-02
Degradation of beta-catenin by the destruction complex 84 5.37e-05 0.255000 3.45e-04
ABC transporters in lipid homeostasis 14 9.87e-02 -0.255000 1.68e-01
Processive synthesis on the C-strand of the telomere 19 5.46e-02 -0.255000 1.05e-01
RA biosynthesis pathway 13 1.13e-01 -0.254000 1.87e-01
tRNA processing 136 3.25e-07 -0.254000 5.04e-06
G-protein mediated events 44 3.60e-03 0.254000 1.17e-02
Initiation of Nuclear Envelope (NE) Reformation 19 5.57e-02 0.254000 1.07e-01
Defects in vitamin and cofactor metabolism 21 4.50e-02 -0.253000 9.05e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.02e-01 -0.253000 1.73e-01
Semaphorin interactions 57 9.69e-04 0.253000 3.93e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 73 1.92e-04 0.252000 9.90e-04
Hemostasis 550 4.64e-24 0.252000 9.04e-22
IRAK2 mediated activation of TAK1 complex 10 1.68e-01 0.252000 2.60e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 4.85e-03 -0.251000 1.47e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.40e-02 -0.251000 5.36e-02
Regulation of lipid metabolism by PPARalpha 106 8.03e-06 0.251000 6.80e-05
Complex I biogenesis 55 1.31e-03 0.250000 5.06e-03
Transcriptional regulation of white adipocyte differentiation 77 1.54e-04 0.249000 8.13e-04
SARS-CoV Infections 83 8.57e-05 0.249000 5.11e-04
Ca-dependent events 29 2.06e-02 0.248000 4.70e-02
p75NTR recruits signalling complexes 12 1.36e-01 0.248000 2.18e-01
Nucleobase catabolism 28 2.31e-02 0.248000 5.18e-02
TICAM1, RIP1-mediated IKK complex recruitment 19 6.20e-02 0.247000 1.16e-01
Transport of the SLBP Dependant Mature mRNA 36 1.02e-02 -0.247000 2.66e-02
NGF-stimulated transcription 31 1.74e-02 0.247000 4.08e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 36 1.04e-02 0.247000 2.71e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 32 1.59e-02 0.246000 3.79e-02
ESR-mediated signaling 161 7.12e-08 0.246000 1.25e-06
Asymmetric localization of PCP proteins 61 8.97e-04 0.246000 3.70e-03
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 1.62e-03 0.246000 6.02e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 3.81e-05 -0.246000 2.54e-04
HDMs demethylate histones 22 4.61e-02 0.246000 9.24e-02
PI3K events in ERBB2 signaling 11 1.59e-01 0.245000 2.47e-01
Translesion synthesis by POLK 17 7.97e-02 -0.245000 1.44e-01
Pyruvate metabolism 28 2.46e-02 0.245000 5.46e-02
Apoptotic execution phase 45 4.42e-03 0.245000 1.37e-02
Signaling by ERBB4 44 4.90e-03 0.245000 1.48e-02
O-glycosylation of TSR domain-containing proteins 27 2.75e-02 -0.245000 6.00e-02
Constitutive Signaling by Overexpressed ERBB2 11 1.59e-01 0.245000 2.48e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 3.05e-02 -0.245000 6.53e-02
CDT1 association with the CDC6:ORC:origin complex 58 1.26e-03 0.245000 4.87e-03
Extra-nuclear estrogen signaling 66 5.87e-04 0.245000 2.61e-03
GRB2 events in ERBB2 signaling 11 1.60e-01 0.245000 2.49e-01
Surfactant metabolism 22 4.72e-02 0.244000 9.42e-02
RHO GTPase Effectors 250 2.84e-11 0.244000 9.69e-10
Laminin interactions 21 5.27e-02 0.244000 1.03e-01
SCF(Skp2)-mediated degradation of p27/p21 60 1.08e-03 0.244000 4.31e-03
SARS-CoV-1 Infection 47 3.90e-03 0.243000 1.25e-02
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 9.23e-02 0.243000 1.60e-01
Aggrephagy 22 4.86e-02 0.243000 9.65e-02
tRNA Aminoacylation 42 6.61e-03 -0.242000 1.90e-02
Gluconeogenesis 28 2.70e-02 0.242000 5.91e-02
Mismatch Repair 15 1.06e-01 -0.241000 1.78e-01
Regulation of RAS by GAPs 67 6.80e-04 0.240000 2.93e-03
Listeria monocytogenes entry into host cells 17 8.67e-02 0.240000 1.53e-01
Nitric oxide stimulates guanylate cyclase 16 9.66e-02 0.240000 1.66e-01
Glycerophospholipid biosynthesis 106 2.03e-05 0.240000 1.48e-04
Nuclear signaling by ERBB4 24 4.24e-02 0.239000 8.63e-02
Signaling by cytosolic FGFR1 fusion mutants 18 7.90e-02 0.239000 1.43e-01
Heme biosynthesis 14 1.21e-01 0.239000 1.98e-01
The citric acid (TCA) cycle and respiratory electron transport 172 6.43e-08 0.239000 1.15e-06
Glycosphingolipid metabolism 36 1.38e-02 0.237000 3.39e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 54 2.68e-03 0.236000 9.12e-03
Constitutive Signaling by NOTCH1 PEST Domain Mutants 54 2.68e-03 0.236000 9.12e-03
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 54 2.68e-03 0.236000 9.12e-03
Signaling by NOTCH1 PEST Domain Mutants in Cancer 54 2.68e-03 0.236000 9.12e-03
Signaling by NOTCH1 in Cancer 54 2.68e-03 0.236000 9.12e-03
EPH-ephrin mediated repulsion of cells 40 9.79e-03 0.236000 2.58e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 9.80e-03 0.236000 2.58e-02
Activation of gene expression by SREBF (SREBP) 42 8.14e-03 0.236000 2.25e-02
mRNA decay by 3' to 5' exoribonuclease 16 1.03e-01 -0.236000 1.74e-01
HDR through Homologous Recombination (HRR) 66 9.26e-04 -0.236000 3.79e-03
Signaling by Hippo 18 8.45e-02 0.235000 1.50e-01
Keratinization 33 1.96e-02 0.235000 4.50e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 1.28e-01 0.235000 2.06e-01
Interleukin-15 signaling 14 1.29e-01 0.234000 2.07e-01
Downstream signaling events of B Cell Receptor (BCR) 80 3.08e-04 0.233000 1.50e-03
Plasma lipoprotein assembly 10 2.02e-01 0.233000 3.05e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 72 6.39e-04 0.233000 2.81e-03
CDK-mediated phosphorylation and removal of Cdc6 72 6.56e-04 0.232000 2.87e-03
Acyl chain remodelling of PG 11 1.82e-01 0.232000 2.79e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 73 6.13e-04 0.232000 2.70e-03
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 8.92e-02 0.231000 1.57e-01
COPI-dependent Golgi-to-ER retrograde traffic 78 4.15e-04 0.231000 1.95e-03
Transport of Mature mRNAs Derived from Intronless Transcripts 43 8.79e-03 -0.231000 2.39e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 76 5.23e-04 0.230000 2.39e-03
Selenoamino acid metabolism 114 2.24e-05 -0.230000 1.61e-04
Degradation of the extracellular matrix 78 4.70e-04 0.229000 2.18e-03
The role of Nef in HIV-1 replication and disease pathogenesis 28 3.60e-02 0.229000 7.48e-02
Beta-catenin independent WNT signaling 137 3.93e-06 0.228000 3.77e-05
Intra-Golgi traffic 43 9.70e-03 0.228000 2.56e-02
Depolymerisation of the Nuclear Lamina 15 1.26e-01 0.228000 2.04e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 75 6.49e-04 0.228000 2.85e-03
Chaperonin-mediated protein folding 84 3.15e-04 0.227000 1.53e-03
Influenza Viral RNA Transcription and Replication 135 5.72e-06 -0.226000 5.14e-05
Oncogene Induced Senescence 33 2.48e-02 0.226000 5.51e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 25 5.14e-02 -0.225000 1.01e-01
NOD1/2 Signaling Pathway 32 2.78e-02 0.225000 6.05e-02
Sphingolipid metabolism 77 6.76e-04 0.224000 2.92e-03
Signaling by NOTCH3 43 1.11e-02 0.224000 2.84e-02
UCH proteinases 87 3.07e-04 0.224000 1.50e-03
Striated Muscle Contraction 24 5.77e-02 0.224000 1.10e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 1.14e-04 -0.223000 6.36e-04
Estrogen-dependent gene expression 99 1.25e-04 0.223000 6.83e-04
Diseases of signal transduction by growth factor receptors and second messengers 343 1.26e-12 0.223000 5.36e-11
Costimulation by the CD28 family 74 9.12e-04 -0.223000 3.75e-03
TP53 Regulates Metabolic Genes 85 3.84e-04 0.223000 1.82e-03
Formation of the beta-catenin:TCF transactivating complex 46 9.07e-03 0.222000 2.44e-02
p53-Dependent G1 DNA Damage Response 64 2.11e-03 0.222000 7.51e-03
p53-Dependent G1/S DNA damage checkpoint 64 2.11e-03 0.222000 7.51e-03
Defective B3GALTL causes Peters-plus syndrome (PpS) 26 5.02e-02 -0.222000 9.94e-02
G1/S DNA Damage Checkpoints 66 2.01e-03 0.220000 7.26e-03
Plasma lipoprotein remodeling 18 1.06e-01 0.220000 1.78e-01
Tryptophan catabolism 12 1.88e-01 0.220000 2.86e-01
Regulation of RUNX2 expression and activity 67 1.92e-03 0.219000 7.00e-03
Acyl chain remodelling of PE 20 9.08e-02 0.218000 1.59e-01
Integrin cell surface interactions 52 6.43e-03 0.218000 1.85e-02
Signaling by ERBB2 in Cancer 21 8.32e-02 0.218000 1.48e-01
Removal of the Flap Intermediate from the C-strand 17 1.20e-01 -0.218000 1.97e-01
Selective autophagy 58 4.23e-03 0.217000 1.33e-02
ABC-family proteins mediated transport 94 2.90e-04 0.216000 1.43e-03
Signaling by Nuclear Receptors 217 4.03e-08 0.216000 7.75e-07
Signaling by WNT 254 3.12e-09 0.216000 7.10e-08
Downregulation of ERBB2 signaling 24 6.87e-02 0.215000 1.28e-01
NOTCH3 Intracellular Domain Regulates Transcription 21 9.00e-02 0.214000 1.58e-01
PTEN Regulation 139 1.39e-05 0.213000 1.08e-04
NRIF signals cell death from the nucleus 15 1.52e-01 0.213000 2.40e-01
RUNX3 regulates NOTCH signaling 14 1.67e-01 0.213000 2.58e-01
Adenylate cyclase inhibitory pathway 11 2.21e-01 0.213000 3.25e-01
SUMOylation of SUMOylation proteins 35 2.93e-02 -0.213000 6.35e-02
Chaperone Mediated Autophagy 20 1.01e-01 0.212000 1.71e-01
Sphingolipid de novo biosynthesis 41 1.89e-02 0.212000 4.36e-02
TCF dependent signaling in response to WNT 166 2.53e-06 0.212000 2.68e-05
Purine salvage 12 2.04e-01 0.212000 3.08e-01
Transport of bile salts and organic acids, metal ions and amine compounds 55 6.67e-03 0.211000 1.91e-02
Interleukin-12 family signaling 53 7.86e-03 0.211000 2.19e-02
FGFR1 mutant receptor activation 24 7.42e-02 0.210000 1.36e-01
Termination of translesion DNA synthesis 32 3.96e-02 -0.210000 8.10e-02
Signaling by Rho GTPases 367 4.55e-12 0.210000 1.82e-10
Transcriptional Regulation by E2F6 34 3.41e-02 -0.210000 7.15e-02
Attenuation phase 23 8.14e-02 0.210000 1.46e-01
Formation of a pool of free 40S subunits 100 2.96e-04 -0.209000 1.45e-03
MHC class II antigen presentation 101 2.86e-04 0.209000 1.42e-03
Sialic acid metabolism 28 5.59e-02 0.209000 1.07e-01
Assembly of active LPL and LIPC lipase complexes 10 2.54e-01 0.208000 3.61e-01
Retinoid metabolism and transport 24 7.73e-02 0.208000 1.40e-01
Negative regulation of FGFR2 signaling 23 8.38e-02 0.208000 1.49e-01
Interleukin-12 signaling 44 1.71e-02 0.208000 4.04e-02
Transcriptional regulation by RUNX3 90 6.83e-04 0.207000 2.93e-03
Metabolism of fat-soluble vitamins 28 5.81e-02 0.207000 1.11e-01
RNA Polymerase I Transcription Initiation 47 1.46e-02 -0.206000 3.52e-02
Interleukin-6 family signaling 18 1.32e-01 0.205000 2.11e-01
Protein folding 90 7.72e-04 0.205000 3.25e-03
Inwardly rectifying K+ channels 24 8.21e-02 0.205000 1.47e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 7.62e-02 0.205000 1.39e-01
Insulin processing 21 1.05e-01 0.204000 1.77e-01
Collagen formation 66 4.13e-03 0.204000 1.30e-02
p75 NTR receptor-mediated signalling 89 8.77e-04 0.204000 3.62e-03
Synthesis of PIPs at the late endosome membrane 11 2.41e-01 0.204000 3.47e-01
Elastic fibre formation 32 4.59e-02 0.204000 9.20e-02
Biosynthesis of DHA-derived SPMs 14 1.87e-01 0.203000 2.85e-01
SUMOylation of intracellular receptors 26 7.54e-02 0.201000 1.37e-01
CaM pathway 27 7.10e-02 0.201000 1.30e-01
Calmodulin induced events 27 7.10e-02 0.201000 1.30e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 1.23e-02 0.201000 3.09e-02
Regulation of TP53 Activity through Acetylation 29 6.19e-02 -0.200000 1.16e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 2.33e-01 -0.199000 3.39e-01
RET signaling 32 5.18e-02 0.199000 1.01e-01
Immune System 1894 1.88e-46 0.198000 8.53e-44
Signaling by FGFR1 38 3.46e-02 0.198000 7.22e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 2.77e-04 -0.197000 1.39e-03
Nonsense-Mediated Decay (NMD) 114 2.77e-04 -0.197000 1.39e-03
NR1H2 and NR1H3-mediated signaling 39 3.40e-02 0.196000 7.14e-02
RIP-mediated NFkB activation via ZBP1 17 1.63e-01 0.196000 2.53e-01
Arachidonic acid metabolism 43 2.66e-02 0.195000 5.84e-02
Signaling by TGF-beta Receptor Complex 72 4.25e-03 0.195000 1.33e-02
Downregulation of TGF-beta receptor signaling 26 8.58e-02 0.195000 1.52e-01
PRC2 methylates histones and DNA 29 7.03e-02 0.194000 1.30e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 1.23e-01 0.194000 2.00e-01
DAP12 interactions 39 3.67e-02 0.193000 7.60e-02
Signaling by ERBB2 TMD/JMD mutants 17 1.69e-01 0.193000 2.61e-01
Cytosolic iron-sulfur cluster assembly 13 2.30e-01 -0.192000 3.34e-01
Cohesin Loading onto Chromatin 10 2.92e-01 0.192000 4.04e-01
Cellular Senescence 144 6.74e-05 0.192000 4.10e-04
BBSome-mediated cargo-targeting to cilium 22 1.18e-01 -0.192000 1.94e-01
DNA Damage/Telomere Stress Induced Senescence 44 2.74e-02 0.192000 6.00e-02
Extracellular matrix organization 219 1.06e-06 0.191000 1.27e-05
Regulation of APC/C activators between G1/S and early anaphase 80 3.16e-03 0.191000 1.05e-02
Ion channel transport 135 1.30e-04 0.191000 7.08e-04
Metabolism of amine-derived hormones 10 2.97e-01 -0.190000 4.08e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 2.18e-01 -0.190000 3.22e-01
Negative regulation of MAPK pathway 42 3.32e-02 0.190000 7.02e-02
ZBP1(DAI) mediated induction of type I IFNs 20 1.43e-01 0.189000 2.26e-01
Metabolism of cofactors 19 1.53e-01 0.189000 2.41e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 6.02e-02 0.189000 1.13e-01
Phospholipid metabolism 185 9.40e-06 0.189000 7.68e-05
Transport of small molecules 561 2.09e-14 0.189000 1.42e-12
Metabolism of steroids 120 3.63e-04 0.188000 1.73e-03
Triglyceride metabolism 25 1.03e-01 0.188000 1.75e-01
RNA Polymerase III Chain Elongation 18 1.67e-01 -0.188000 2.58e-01
Nuclear Pore Complex (NPC) Disassembly 36 5.20e-02 -0.187000 1.02e-01
Antiviral mechanism by IFN-stimulated genes 80 3.84e-03 -0.187000 1.24e-02
Activation of HOX genes during differentiation 69 7.31e-03 0.187000 2.06e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 69 7.31e-03 0.187000 2.06e-02
PKA-mediated phosphorylation of CREB 17 1.83e-01 0.186000 2.80e-01
Signaling by ERBB2 KD Mutants 20 1.50e-01 0.186000 2.36e-01
PIP3 activates AKT signaling 241 7.21e-07 0.185000 9.79e-06
PINK1-PRKN Mediated Mitophagy 21 1.42e-01 0.185000 2.26e-01
Synthesis of PE 12 2.69e-01 -0.184000 3.79e-01
CD209 (DC-SIGN) signaling 20 1.54e-01 0.184000 2.41e-01
Signaling by TGFB family members 91 2.40e-03 0.184000 8.41e-03
Stimuli-sensing channels 74 6.32e-03 0.184000 1.83e-02
Influenza Infection 154 9.35e-05 -0.182000 5.48e-04
Disorders of developmental biology 12 2.75e-01 0.182000 3.86e-01
Loss of function of MECP2 in Rett syndrome 12 2.75e-01 0.182000 3.86e-01
Pervasive developmental disorders 12 2.75e-01 0.182000 3.86e-01
FRS-mediated FGFR3 signaling 11 2.96e-01 0.182000 4.07e-01
Regulation of IFNA signaling 12 2.76e-01 0.182000 3.87e-01
Peroxisomal protein import 57 1.78e-02 0.181000 4.13e-02
Regulation of localization of FOXO transcription factors 12 2.77e-01 0.181000 3.88e-01
Transcriptional regulation by RUNX2 103 1.48e-03 0.181000 5.63e-03
Resolution of D-Loop Structures 33 7.17e-02 -0.181000 1.32e-01
Mitophagy 28 9.74e-02 0.181000 1.67e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 2.78e-01 0.181000 3.88e-01
SUMOylation of RNA binding proteins 47 3.20e-02 -0.181000 6.79e-02
Regulation of actin dynamics for phagocytic cup formation 123 5.35e-04 0.181000 2.41e-03
Glutathione conjugation 26 1.11e-01 0.181000 1.84e-01
Metabolism of lipids 625 1.26e-14 0.181000 9.04e-13
Assembly of the pre-replicative complex 67 1.07e-02 0.180000 2.77e-02
SUMOylation of ubiquitinylation proteins 39 5.17e-02 -0.180000 1.01e-01
APC/C-mediated degradation of cell cycle proteins 87 3.88e-03 0.179000 1.24e-02
Regulation of mitotic cell cycle 87 3.88e-03 0.179000 1.24e-02
Diseases associated with O-glycosylation of proteins 49 3.02e-02 -0.179000 6.50e-02
Intracellular signaling by second messengers 273 3.71e-07 0.179000 5.56e-06
Factors involved in megakaryocyte development and platelet production 117 8.63e-04 0.178000 3.58e-03
Resolution of D-loop Structures through Holliday Junction Intermediates 32 8.16e-02 -0.178000 1.46e-01
Ub-specific processing proteases 171 6.23e-05 0.177000 3.89e-04
Chemokine receptors bind chemokines 39 5.55e-02 -0.177000 1.07e-01
Cell junction organization 60 1.79e-02 0.177000 4.16e-02
Synthesis of very long-chain fatty acyl-CoAs 22 1.53e-01 0.176000 2.41e-01
Retrograde transport at the Trans-Golgi-Network 49 3.38e-02 0.175000 7.13e-02
Apoptotic cleavage of cellular proteins 34 7.73e-02 0.175000 1.40e-01
Meiotic synapsis 45 4.32e-02 0.174000 8.76e-02
RNA Polymerase III Transcription Initiation 36 7.09e-02 -0.174000 1.30e-01
Cyclin E associated events during G1/S transition 83 6.17e-03 0.174000 1.81e-02
Maturation of nucleoprotein 10 3.42e-01 -0.173000 4.56e-01
Regulation of PTEN gene transcription 59 2.13e-02 0.173000 4.82e-02
Circadian Clock 67 1.43e-02 0.173000 3.46e-02
Deubiquitination 242 4.12e-06 0.172000 3.82e-05
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 80 8.16e-03 0.171000 2.25e-02
Signaling by Hedgehog 121 1.17e-03 0.171000 4.63e-03
Peroxisomal lipid metabolism 27 1.25e-01 0.171000 2.02e-01
CD28 dependent Vav1 pathway 12 3.06e-01 0.171000 4.18e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 2.24e-01 -0.170000 3.28e-01
Activation of kainate receptors upon glutamate binding 26 1.33e-01 0.170000 2.13e-01
Unfolded Protein Response (UPR) 87 6.30e-03 0.169000 1.83e-02
Class I MHC mediated antigen processing & presentation 350 5.20e-08 0.169000 9.45e-07
Nef mediated downregulation of MHC class I complex cell surface expression 10 3.54e-01 0.169000 4.68e-01
Assembly of collagen fibrils and other multimeric structures 42 5.85e-02 0.169000 1.11e-01
Peptide hormone metabolism 50 3.92e-02 0.169000 8.04e-02
VEGFR2 mediated cell proliferation 18 2.16e-01 0.168000 3.20e-01
G alpha (12/13) signalling events 69 1.59e-02 0.168000 3.79e-02
Incretin synthesis, secretion, and inactivation 10 3.58e-01 0.168000 4.70e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 10 3.58e-01 0.168000 4.70e-01
HCMV Late Events 69 1.60e-02 0.168000 3.81e-02
Signaling by FGFR1 in disease 31 1.06e-01 0.168000 1.78e-01
Dual Incision in GG-NER 41 6.34e-02 -0.168000 1.18e-01
Recognition of DNA damage by PCNA-containing replication complex 30 1.12e-01 -0.167000 1.86e-01
Other semaphorin interactions 16 2.46e-01 0.167000 3.52e-01
MAPK1/MAPK3 signaling 236 9.87e-06 0.167000 7.92e-05
HS-GAG biosynthesis 20 1.97e-01 0.167000 2.97e-01
Pausing and recovery of Tat-mediated HIV elongation 30 1.14e-01 0.167000 1.88e-01
Tat-mediated HIV elongation arrest and recovery 30 1.14e-01 0.167000 1.88e-01
Mitochondrial biogenesis 88 7.03e-03 0.166000 1.99e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 2.23e-01 0.166000 3.27e-01
Neurotransmitter receptors and postsynaptic signal transmission 124 1.45e-03 0.166000 5.53e-03
Carboxyterminal post-translational modifications of tubulin 27 1.37e-01 0.165000 2.19e-01
Signaling by ERBB2 44 5.82e-02 0.165000 1.11e-01
Signaling by PDGFR in disease 19 2.14e-01 0.165000 3.20e-01
MAPK family signaling cascades 270 3.26e-06 0.164000 3.27e-05
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 3.46e-01 0.164000 4.59e-01
NCAM1 interactions 23 1.73e-01 -0.164000 2.66e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 2.07e-01 0.163000 3.11e-01
Trafficking of AMPA receptors 20 2.07e-01 0.163000 3.11e-01
Glycosaminoglycan metabolism 94 6.37e-03 0.163000 1.84e-02
Rho GTPase cycle 126 1.60e-03 0.163000 5.99e-03
Fcgamma receptor (FCGR) dependent phagocytosis 147 6.62e-04 0.163000 2.89e-03
Downstream signal transduction 27 1.44e-01 0.162000 2.28e-01
Metabolism of carbohydrates 244 1.31e-05 0.162000 1.02e-04
Aflatoxin activation and detoxification 14 2.94e-01 0.162000 4.06e-01
SUMOylation of DNA damage response and repair proteins 77 1.42e-02 -0.162000 3.45e-02
Dectin-2 family 19 2.23e-01 0.162000 3.27e-01
NOTCH2 intracellular domain regulates transcription 11 3.54e-01 0.161000 4.68e-01
rRNA processing in the mitochondrion 29 1.33e-01 -0.161000 2.13e-01
Insulin receptor signalling cascade 39 8.17e-02 0.161000 1.46e-01
Phase 0 - rapid depolarisation 28 1.40e-01 -0.161000 2.23e-01
FLT3 Signaling 245 1.54e-05 0.160000 1.17e-04
Intrinsic Pathway for Apoptosis 53 4.38e-02 0.160000 8.86e-02
Leishmania infection 245 1.81e-05 0.159000 1.36e-04
A tetrasaccharide linker sequence is required for GAG synthesis 17 2.57e-01 -0.159000 3.64e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 1.63e-01 0.158000 2.53e-01
Activation of RAC1 11 3.65e-01 0.158000 4.78e-01
HIV elongation arrest and recovery 32 1.23e-01 0.158000 2.00e-01
Pausing and recovery of HIV elongation 32 1.23e-01 0.158000 2.00e-01
Cyclin A:Cdk2-associated events at S phase entry 85 1.20e-02 0.158000 3.03e-02
RAF/MAP kinase cascade 231 3.79e-05 0.157000 2.54e-04
Interferon Signaling 177 3.18e-04 -0.157000 1.54e-03
Metabolic disorders of biological oxidation enzymes 26 1.67e-01 0.157000 2.58e-01
Neddylation 219 6.71e-05 0.156000 4.10e-04
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 2.24e-02 -0.156000 5.04e-02
Hedgehog 'off' state 93 9.50e-03 0.156000 2.54e-02
Defects in cobalamin (B12) metabolism 13 3.32e-01 -0.155000 4.48e-01
FRS-mediated FGFR4 signaling 12 3.52e-01 0.155000 4.66e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 1.98e-01 0.155000 2.99e-01
FCGR3A-mediated phagocytosis 121 3.26e-03 0.155000 1.08e-02
Leishmania phagocytosis 121 3.26e-03 0.155000 1.08e-02
Parasite infection 121 3.26e-03 0.155000 1.08e-02
Signaling by ERBB2 ECD mutants 15 3.00e-01 0.155000 4.12e-01
Fatty acyl-CoA biosynthesis 35 1.14e-01 0.154000 1.88e-01
Bile acid and bile salt metabolism 28 1.58e-01 0.154000 2.47e-01
Deadenylation of mRNA 22 2.11e-01 0.154000 3.16e-01
Degradation of cysteine and homocysteine 12 3.56e-01 0.154000 4.70e-01
Downregulation of ERBB2:ERBB3 signaling 12 3.56e-01 0.154000 4.70e-01
TNFR2 non-canonical NF-kB pathway 96 9.35e-03 0.153000 2.50e-02
Transport of vitamins, nucleosides, and related molecules 33 1.27e-01 0.153000 2.05e-01
ISG15 antiviral mechanism 72 2.46e-02 -0.153000 5.46e-02
Fatty acid metabolism 153 1.09e-03 0.153000 4.33e-03
Early Phase of HIV Life Cycle 14 3.25e-01 -0.152000 4.40e-01
Collagen biosynthesis and modifying enzymes 48 6.88e-02 0.152000 1.28e-01
Blood group systems biosynthesis 17 2.79e-01 0.152000 3.89e-01
Signal Transduction 1894 8.20e-28 0.152000 1.86e-25
Post-translational protein modification 1194 1.26e-18 0.151000 1.32e-16
Formation of RNA Pol II elongation complex 57 5.05e-02 0.150000 9.96e-02
RNA Polymerase II Transcription Elongation 57 5.05e-02 0.150000 9.96e-02
Signaling by NTRK2 (TRKB) 20 2.47e-01 0.150000 3.53e-01
Transcriptional regulation by RUNX1 185 4.57e-04 0.149000 2.13e-03
Cell death signalling via NRAGE, NRIF and NADE 70 3.09e-02 0.149000 6.59e-02
SLBP independent Processing of Histone Pre-mRNAs 10 4.15e-01 -0.149000 5.31e-01
tRNA processing in the mitochondrion 32 1.45e-01 -0.149000 2.29e-01
HCMV Infection 96 1.17e-02 0.149000 2.97e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 111 6.89e-03 -0.148000 1.97e-02
Interferon gamma signaling 83 2.00e-02 -0.148000 4.58e-02
Disorders of transmembrane transporters 148 1.94e-03 0.148000 7.05e-03
Death Receptor Signalling 132 3.42e-03 0.148000 1.12e-02
Signaling by PDGF 44 9.05e-02 0.147000 1.58e-01
Cell-Cell communication 89 1.67e-02 0.147000 3.96e-02
Miscellaneous transport and binding events 20 2.56e-01 0.147000 3.63e-01
Transcriptional Regulation by MECP2 47 8.24e-02 0.146000 1.47e-01
MET activates PTK2 signaling 15 3.26e-01 0.146000 4.42e-01
Cytosolic sulfonation of small molecules 19 2.72e-01 0.146000 3.83e-01
B-WICH complex positively regulates rRNA expression 47 8.49e-02 0.145000 1.51e-01
Vitamin B5 (pantothenate) metabolism 17 3.01e-01 0.145000 4.13e-01
Transmission across Chemical Synapses 172 1.04e-03 0.145000 4.20e-03
Cellular responses to external stimuli 506 2.59e-08 0.145000 5.20e-07
SUMOylation of DNA replication proteins 46 9.00e-02 -0.144000 1.58e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 8.88e-03 -0.144000 2.41e-02
Fc epsilon receptor (FCERI) signaling 191 6.72e-04 0.143000 2.92e-03
Regulation of TP53 Activity through Association with Co-factors 12 3.93e-01 -0.143000 5.08e-01
Synthesis of bile acids and bile salts 24 2.27e-01 0.142000 3.32e-01
Muscle contraction 142 3.45e-03 0.142000 1.13e-02
SUMOylation of chromatin organization proteins 57 6.53e-02 -0.141000 1.22e-01
RAF-independent MAPK1/3 activation 21 2.64e-01 0.141000 3.73e-01
Cellular responses to stress 500 7.40e-08 0.141000 1.28e-06
NoRC negatively regulates rRNA expression 62 5.63e-02 0.140000 1.08e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 2.37e-01 0.139000 3.43e-01
HIV Transcription Initiation 45 1.06e-01 0.139000 1.77e-01
RNA Polymerase II HIV Promoter Escape 45 1.06e-01 0.139000 1.77e-01
RNA Polymerase II Promoter Escape 45 1.06e-01 0.139000 1.77e-01
RNA Polymerase II Transcription Initiation 45 1.06e-01 0.139000 1.77e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 1.06e-01 0.139000 1.77e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 1.06e-01 0.139000 1.77e-01
Metabolism of folate and pterines 16 3.34e-01 0.139000 4.49e-01
Cell surface interactions at the vascular wall 174 1.52e-03 0.139000 5.73e-03
Cyclin A/B1/B2 associated events during G2/M transition 25 2.28e-01 0.139000 3.33e-01
HS-GAG degradation 16 3.36e-01 0.139000 4.51e-01
Signaling by FGFR2 IIIa TM 18 3.08e-01 0.139000 4.20e-01
Metabolism 1772 3.22e-22 0.139000 5.48e-20
RNA Polymerase I Transcription Termination 30 1.90e-01 -0.138000 2.89e-01
Negative regulation of the PI3K/AKT network 87 2.61e-02 0.138000 5.75e-02
FRS-mediated FGFR1 signaling 14 3.75e-01 0.137000 4.88e-01
Regulation of MECP2 expression and activity 28 2.10e-01 0.137000 3.14e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 4.54e-01 0.137000 5.68e-01
Polo-like kinase mediated events 16 3.44e-01 0.137000 4.58e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 2.20e-01 0.136000 3.24e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 2.20e-01 0.136000 3.24e-01
Translation of structural proteins 28 2.12e-01 0.136000 3.16e-01
Transport of Mature Transcript to Cytoplasm 81 3.40e-02 -0.136000 7.14e-02
Acyl chain remodelling of PS 14 3.80e-01 0.136000 4.94e-01
Synthesis of PIPs at the plasma membrane 52 9.12e-02 0.135000 1.59e-01
TP53 Regulates Transcription of Cell Death Genes 43 1.25e-01 0.135000 2.02e-01
SRP-dependent cotranslational protein targeting to membrane 111 1.39e-02 -0.135000 3.41e-02
O-linked glycosylation of mucins 47 1.09e-01 0.135000 1.82e-01
Metal ion SLC transporters 21 2.85e-01 0.135000 3.95e-01
Signaling by Activin 10 4.60e-01 -0.135000 5.73e-01
RNA Polymerase I Promoter Escape 47 1.11e-01 0.134000 1.85e-01
Zinc transporters 14 3.85e-01 0.134000 5.01e-01
Phase 4 - resting membrane potential 10 4.66e-01 0.133000 5.79e-01
Developmental Biology 732 8.35e-10 0.133000 2.19e-08
Cap-dependent Translation Initiation 118 1.26e-02 -0.133000 3.14e-02
Eukaryotic Translation Initiation 118 1.26e-02 -0.133000 3.14e-02
Downstream signaling of activated FGFR3 16 3.59e-01 0.132000 4.71e-01
Cytosolic tRNA aminoacylation 24 2.65e-01 -0.132000 3.74e-01
Folding of actin by CCT/TriC 10 4.72e-01 0.131000 5.84e-01
Long-term potentiation 14 3.95e-01 -0.131000 5.10e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 3.51e-01 -0.131000 4.66e-01
Regulation of beta-cell development 19 3.25e-01 0.131000 4.40e-01
RNA Polymerase II Pre-transcription Events 78 4.70e-02 0.130000 9.39e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 4.17e-01 0.130000 5.32e-01
Viral Messenger RNA Synthesis 44 1.37e-01 -0.130000 2.18e-01
Translesion Synthesis by POLH 18 3.41e-01 -0.130000 4.55e-01
Metabolism of proteins 1719 6.35e-19 0.129000 7.21e-17
Orc1 removal from chromatin 70 6.24e-02 0.129000 1.17e-01
SUMOylation of transcription factors 16 3.74e-01 0.128000 4.88e-01
Telomere Extension By Telomerase 23 2.88e-01 -0.128000 3.98e-01
Synthesis of substrates in N-glycan biosythesis 58 9.20e-02 0.128000 1.60e-01
Protein methylation 15 3.91e-01 0.128000 5.07e-01
Disease 1303 1.03e-14 0.127000 7.80e-13
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 2.44e-01 -0.127000 3.50e-01
Amino acid transport across the plasma membrane 24 2.83e-01 0.127000 3.94e-01
HIV Infection 225 1.07e-03 0.127000 4.30e-03
RUNX3 regulates p14-ARF 10 4.90e-01 0.126000 6.03e-01
Potassium Channels 64 8.16e-02 0.126000 1.46e-01
RAS processing 19 3.42e-01 0.126000 4.56e-01
Transcriptional regulation of pluripotent stem cells 20 3.32e-01 0.125000 4.48e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 2.80e-01 0.125000 3.89e-01
FOXO-mediated transcription 59 9.92e-02 0.124000 1.69e-01
Formation of the Early Elongation Complex 33 2.18e-01 0.124000 3.22e-01
Formation of the HIV-1 Early Elongation Complex 33 2.18e-01 0.124000 3.22e-01
Repression of WNT target genes 14 4.23e-01 -0.124000 5.37e-01
Class I peroxisomal membrane protein import 20 3.39e-01 -0.124000 4.53e-01
HSF1-dependent transactivation 29 2.52e-01 0.123000 3.58e-01
Meiotic recombination 38 1.90e-01 0.123000 2.88e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 4.10e-01 -0.123000 5.26e-01
DAG and IP3 signaling 33 2.26e-01 0.122000 3.31e-01
Signaling by FGFR in disease 51 1.34e-01 0.121000 2.13e-01
Axon guidance 457 1.01e-05 0.120000 8.04e-05
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 182 5.15e-03 -0.120000 1.55e-02
FCERI mediated NF-kB activation 138 1.54e-02 0.119000 3.70e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 3.55e-01 0.119000 4.69e-01
E2F mediated regulation of DNA replication 22 3.32e-01 -0.119000 4.48e-01
Ephrin signaling 18 3.81e-01 0.119000 4.95e-01
Regulation of TP53 Activity through Methylation 19 3.68e-01 -0.119000 4.82e-01
Neuronal System 259 9.55e-04 0.119000 3.89e-03
Infectious disease 724 4.92e-08 0.119000 9.06e-07
Platelet calcium homeostasis 22 3.35e-01 0.119000 4.50e-01
Signaling by NOTCH2 30 2.61e-01 0.119000 3.69e-01
ECM proteoglycans 35 2.26e-01 0.118000 3.31e-01
Non-integrin membrane-ECM interactions 37 2.16e-01 0.118000 3.20e-01
Mitotic Prophase 98 4.50e-02 0.117000 9.05e-02
Downstream signaling of activated FGFR4 17 4.05e-01 0.117000 5.23e-01
Keratan sulfate/keratin metabolism 27 2.95e-01 0.116000 4.07e-01
Protein localization 157 1.19e-02 0.116000 3.00e-02
Molecules associated with elastic fibres 22 3.46e-01 0.116000 4.59e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.27e-01 0.116000 6.36e-01
RNA polymerase II transcribes snRNA genes 72 9.10e-02 0.115000 1.59e-01
Nuclear Envelope (NE) Reassembly 69 9.84e-02 0.115000 1.68e-01
Nervous system development 476 1.99e-05 0.114000 1.47e-04
SHC-mediated cascade:FGFR4 10 5.33e-01 0.114000 6.43e-01
Ca2+ pathway 57 1.39e-01 0.113000 2.22e-01
Mitotic Anaphase 224 3.83e-03 0.112000 1.23e-02
Heparan sulfate/heparin (HS-GAG) metabolism 37 2.38e-01 0.112000 3.44e-01
PI Metabolism 80 8.62e-02 0.111000 1.52e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 2.37e-01 -0.111000 3.43e-01
FCGR activation 76 9.51e-02 -0.111000 1.64e-01
Assembly and cell surface presentation of NMDA receptors 18 4.18e-01 -0.110000 5.33e-01
Metabolism of nucleotides 86 7.81e-02 0.110000 1.42e-01
Phase I - Functionalization of compounds 65 1.26e-01 0.110000 2.04e-01
VEGFR2 mediated vascular permeability 27 3.24e-01 0.110000 4.40e-01
RUNX2 regulates osteoblast differentiation 19 4.08e-01 -0.110000 5.24e-01
The phototransduction cascade 26 3.34e-01 -0.109000 4.49e-01
Formation of TC-NER Pre-Incision Complex 53 1.70e-01 0.109000 2.62e-01
Regulation of TNFR1 signaling 32 2.87e-01 -0.109000 3.98e-01
Antigen processing: Ubiquitination & Proteasome degradation 289 1.48e-03 0.109000 5.63e-03
Regulation of pyruvate dehydrogenase (PDH) complex 15 4.67e-01 0.108000 5.80e-01
Chromosome Maintenance 105 5.59e-02 -0.108000 1.07e-01
Interleukin-20 family signaling 17 4.42e-01 0.108000 5.56e-01
Mitotic Metaphase and Anaphase 225 5.46e-03 0.107000 1.62e-02
MECP2 regulates neuronal receptors and channels 13 5.04e-01 0.107000 6.15e-01
Cytokine Signaling in Immune system 736 8.49e-07 0.107000 1.11e-05
Adherens junctions interactions 19 4.25e-01 0.106000 5.39e-01
Glucose metabolism 84 9.53e-02 0.105000 1.64e-01
Regulation of TP53 Activity 152 2.55e-02 -0.105000 5.62e-02
DNA Double-Strand Break Repair 135 3.73e-02 -0.104000 7.70e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 2.45e-01 0.104000 3.51e-01
HIV Transcription Elongation 42 2.45e-01 0.104000 3.51e-01
Tat-mediated elongation of the HIV-1 transcript 42 2.45e-01 0.104000 3.51e-01
Generic Transcription Pathway 1085 9.34e-09 -0.103000 1.96e-07
Negative epigenetic regulation of rRNA expression 65 1.50e-01 0.103000 2.37e-01
Phase II - Conjugation of compounds 68 1.41e-01 0.103000 2.25e-01
Glycolysis 67 1.44e-01 0.103000 2.28e-01
Nicotinamide salvaging 14 5.04e-01 -0.103000 6.15e-01
Acetylcholine Neurotransmitter Release Cycle 11 5.56e-01 -0.103000 6.64e-01
SLC-mediated transmembrane transport 180 1.76e-02 0.103000 4.11e-02
Gene expression (Transcription) 1335 3.26e-10 -0.102000 9.66e-09
Cilium Assembly 181 1.77e-02 -0.102000 4.12e-02
Cellular hexose transport 15 4.96e-01 -0.101000 6.08e-01
PI3K/AKT Signaling in Cancer 81 1.15e-01 0.101000 1.89e-01
Signaling by FGFR2 60 1.77e-01 0.101000 2.71e-01
Activation of NMDA receptors and postsynaptic events 58 1.85e-01 0.101000 2.82e-01
CD22 mediated BCR regulation 59 1.83e-01 -0.100000 2.79e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 2.51e-01 0.100000 3.57e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 5.49e-01 0.099800 6.60e-01
Transcriptional activation of mitochondrial biogenesis 51 2.18e-01 0.099700 3.22e-01
SHC-mediated cascade:FGFR1 12 5.51e-01 0.099400 6.60e-01
Mitochondrial calcium ion transport 22 4.22e-01 0.098800 5.37e-01
PI-3K cascade:FGFR4 10 5.89e-01 0.098800 6.92e-01
The canonical retinoid cycle in rods (twilight vision) 10 5.90e-01 0.098500 6.92e-01
Classical antibody-mediated complement activation 69 1.63e-01 -0.097100 2.53e-01
Cytochrome P450 - arranged by substrate type 36 3.14e-01 0.097000 4.27e-01
Interleukin receptor SHC signaling 23 4.22e-01 0.096700 5.37e-01
Diseases associated with glycosaminoglycan metabolism 26 3.94e-01 0.096500 5.10e-01
Biological oxidations 138 5.05e-02 0.096400 9.96e-02
Endosomal/Vacuolar pathway 12 5.64e-01 -0.096100 6.72e-01
Signaling by the B Cell Receptor (BCR) 163 3.46e-02 0.095900 7.22e-02
Interconversion of nucleotide di- and triphosphates 27 3.89e-01 0.095700 5.05e-01
Switching of origins to a post-replicative state 90 1.17e-01 0.095700 1.92e-01
Regulation of KIT signaling 15 5.21e-01 0.095700 6.31e-01
G alpha (i) signalling events 246 9.90e-03 0.095500 2.59e-02
N-Glycan antennae elongation 13 5.53e-01 -0.095000 6.62e-01
Synthesis of IP3 and IP4 in the cytosol 22 4.41e-01 0.095000 5.54e-01
Post NMDA receptor activation events 48 2.56e-01 0.094800 3.63e-01
Nuclear Envelope Breakdown 53 2.34e-01 -0.094500 3.40e-01
Regulation of TP53 Activity through Phosphorylation 88 1.26e-01 -0.094500 2.03e-01
Glutamate and glutamine metabolism 12 5.73e-01 -0.094000 6.80e-01
DNA Damage Bypass 47 2.65e-01 -0.093900 3.74e-01
Condensation of Prometaphase Chromosomes 11 5.90e-01 0.093900 6.92e-01
RNA Polymerase III Abortive And Retractive Initiation 41 3.03e-01 -0.093000 4.14e-01
RNA Polymerase III Transcription 41 3.03e-01 -0.093000 4.14e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 2.77e-01 0.092600 3.88e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 1.72e-01 0.092500 2.64e-01
IGF1R signaling cascade 36 3.37e-01 0.092400 4.51e-01
HSF1 activation 26 4.17e-01 0.092000 5.32e-01
Separation of Sister Chromatids 168 3.97e-02 0.092000 8.12e-02
Cholesterol biosynthesis 24 4.36e-01 0.091900 5.49e-01
Signaling by FGFR 69 1.87e-01 0.091800 2.85e-01
Homology Directed Repair 110 9.69e-02 -0.091600 1.66e-01
Downstream signaling of activated FGFR1 20 4.79e-01 0.091500 5.92e-01
Phase 2 - plateau phase 17 5.17e-01 -0.090800 6.28e-01
Interleukin-2 family signaling 38 3.35e-01 0.090500 4.49e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 5.75e-01 0.089700 6.81e-01
Metabolism of RNA 688 6.49e-05 -0.089300 4.02e-04
Purine catabolism 16 5.37e-01 0.089200 6.46e-01
Inositol phosphate metabolism 42 3.17e-01 0.089200 4.31e-01
STING mediated induction of host immune responses 15 5.55e-01 0.088100 6.63e-01
Processing of Intronless Pre-mRNAs 19 5.08e-01 -0.087800 6.19e-01
RNA Polymerase II Transcription 1204 3.79e-07 -0.086900 5.61e-06
PI-3K cascade:FGFR1 12 6.02e-01 0.086900 7.04e-01
mRNA Capping 29 4.18e-01 0.086900 5.33e-01
Nonhomologous End-Joining (NHEJ) 42 3.34e-01 0.086200 4.49e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 3.71e-01 0.086100 4.85e-01
G alpha (q) signalling events 134 8.57e-02 0.086000 1.52e-01
NRAGE signals death through JNK 53 2.79e-01 0.085900 3.89e-01
M Phase 361 5.15e-03 0.085700 1.55e-02
Creation of C4 and C2 activators 71 2.12e-01 -0.085700 3.16e-01
Elevation of cytosolic Ca2+ levels 13 5.94e-01 0.085500 6.96e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 5.42e-01 -0.085300 6.52e-01
Fertilization 12 6.10e-01 0.085100 7.12e-01
Mitotic G2-G2/M phases 183 4.73e-02 0.085000 9.42e-02
Nephrin family interactions 18 5.34e-01 -0.084600 6.44e-01
Signaling by WNT in cancer 30 4.25e-01 0.084100 5.39e-01
Lysine catabolism 11 6.30e-01 0.083900 7.30e-01
Recruitment of NuMA to mitotic centrosomes 80 1.95e-01 -0.083800 2.95e-01
G1/S-Specific Transcription 29 4.36e-01 -0.083600 5.49e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 3.03e-01 -0.083400 4.14e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 4.89e-01 0.083400 6.02e-01
DNA Repair 289 1.49e-02 -0.083200 3.59e-02
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 4.92e-01 0.082800 6.04e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 5.57e-01 -0.082300 6.64e-01
Transcription of the HIV genome 67 2.44e-01 0.082300 3.50e-01
Initial triggering of complement 78 2.09e-01 -0.082200 3.14e-01
Prolactin receptor signaling 11 6.41e-01 0.081100 7.38e-01
Activation of BH3-only proteins 30 4.43e-01 0.081000 5.56e-01
Regulation of HSF1-mediated heat shock response 79 2.16e-01 -0.080600 3.20e-01
IRS-related events triggered by IGF1R 35 4.10e-01 0.080600 5.25e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 4.95e-01 0.080500 6.07e-01
DNA Double Strand Break Response 47 3.43e-01 0.080000 4.56e-01
Centrosome maturation 81 2.15e-01 -0.079700 3.20e-01
Recruitment of mitotic centrosome proteins and complexes 81 2.15e-01 -0.079700 3.20e-01
PKMTs methylate histone lysines 45 3.57e-01 -0.079400 4.70e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 6.49e-01 -0.079300 7.45e-01
NCAM signaling for neurite out-growth 43 3.69e-01 -0.079200 4.82e-01
Olfactory Signaling Pathway 60 2.89e-01 0.079100 4.00e-01
TNFs bind their physiological receptors 25 4.94e-01 -0.079100 6.06e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 6.50e-01 -0.079100 7.45e-01
Host Interactions of HIV factors 130 1.20e-01 0.078900 1.97e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 5.75e-01 -0.078600 6.81e-01
Sema3A PAK dependent Axon repulsion 16 5.86e-01 0.078600 6.91e-01
Role of phospholipids in phagocytosis 88 2.06e-01 -0.077900 3.10e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 5.00e-01 -0.077900 6.12e-01
G2/M Transition 181 7.10e-02 0.077800 1.30e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 4.08e-01 0.077600 5.24e-01
Positive epigenetic regulation of rRNA expression 62 3.06e-01 0.075200 4.17e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 10 6.80e-01 -0.075200 7.72e-01
Anchoring of the basal body to the plasma membrane 97 2.02e-01 -0.075000 3.04e-01
Transcriptional regulation by small RNAs 63 3.05e-01 0.074700 4.17e-01
Adaptive Immune System 757 4.84e-04 0.074500 2.24e-03
ADORA2B mediated anti-inflammatory cytokines production 73 2.77e-01 0.073600 3.88e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 5.79e-01 -0.073500 6.85e-01
Interleukin-7 signaling 21 5.60e-01 0.073400 6.68e-01
Signaling by GPCR 545 3.48e-03 0.073200 1.14e-02
Cell-cell junction organization 39 4.30e-01 0.073000 5.44e-01
GPCR downstream signalling 501 5.39e-03 0.072600 1.61e-02
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 37 4.46e-01 0.072300 5.59e-01
TICAM1-dependent activation of IRF3/IRF7 12 6.65e-01 0.072300 7.57e-01
TCR signaling 122 1.69e-01 0.072100 2.61e-01
Signaling by NTRK3 (TRKC) 16 6.18e-01 0.072000 7.18e-01
TRP channels 19 5.89e-01 -0.071600 6.92e-01
Neurotransmitter release cycle 39 4.42e-01 0.071100 5.56e-01
Signaling by FGFR4 in disease 11 6.85e-01 0.070700 7.75e-01
Downstream TCR signaling 101 2.21e-01 0.070500 3.25e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 6.74e-01 0.070200 7.66e-01
Peptide ligand-binding receptors 97 2.32e-01 0.070200 3.38e-01
Ovarian tumor domain proteases 37 4.64e-01 0.069600 5.77e-01
Cellular response to heat stress 93 2.49e-01 -0.069200 3.54e-01
Regulation of RUNX1 Expression and Activity 18 6.11e-01 -0.069200 7.13e-01
Basigin interactions 23 5.66e-01 0.069100 6.73e-01
RIPK1-mediated regulated necrosis 16 6.33e-01 0.069000 7.31e-01
Regulated Necrosis 16 6.33e-01 0.069000 7.31e-01
Synthesis, secretion, and deacylation of Ghrelin 11 6.96e-01 -0.068000 7.84e-01
WNT ligand biogenesis and trafficking 21 5.93e-01 0.067300 6.96e-01
Cyclin D associated events in G1 47 4.32e-01 0.066300 5.45e-01
G1 Phase 47 4.32e-01 0.066300 5.45e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 2.43e-01 -0.066200 3.49e-01
MicroRNA (miRNA) biogenesis 24 5.75e-01 0.066100 6.81e-01
G alpha (s) signalling events 143 1.73e-01 0.066000 2.66e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 6.95e-01 -0.065400 7.83e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 3.95e-01 0.065100 5.10e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 63 3.72e-01 0.065000 4.86e-01
NOTCH4 Intracellular Domain Regulates Transcription 18 6.34e-01 0.064800 7.32e-01
SUMOylation of transcription cofactors 44 4.58e-01 0.064700 5.72e-01
Pregnenolone biosynthesis 10 7.29e-01 0.063400 8.11e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 4.74e-01 0.063100 5.87e-01
IRS-mediated signalling 34 5.25e-01 0.063000 6.34e-01
Establishment of Sister Chromatid Cohesion 11 7.19e-01 0.062700 8.04e-01
Base Excision Repair 58 4.13e-01 -0.062200 5.28e-01
Receptor-type tyrosine-protein phosphatases 12 7.09e-01 0.062100 7.96e-01
TRAF6 mediated IRF7 activation 15 6.77e-01 0.062100 7.69e-01
PI-3K cascade:FGFR2 12 7.14e-01 -0.061100 8.00e-01
Late Phase of HIV Life Cycle 131 2.29e-01 0.060900 3.34e-01
FGFR2 alternative splicing 25 5.99e-01 0.060800 7.01e-01
Regulation of PTEN mRNA translation 13 7.06e-01 -0.060400 7.94e-01
Interleukin-37 signaling 19 6.53e-01 0.059600 7.48e-01
Branched-chain amino acid catabolism 21 6.37e-01 -0.059600 7.34e-01
Constitutive Signaling by Aberrant PI3K in Cancer 54 4.55e-01 0.058800 5.68e-01
Xenobiotics 12 7.26e-01 -0.058500 8.08e-01
Other interleukin signaling 18 6.71e-01 0.057800 7.64e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 4.89e-01 0.057800 6.02e-01
Loss of Nlp from mitotic centrosomes 69 4.07e-01 -0.057700 5.24e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 4.07e-01 -0.057700 5.24e-01
Transcriptional Regulation by VENTX 38 5.42e-01 -0.057100 6.52e-01
Eicosanoid ligand-binding receptors 13 7.22e-01 -0.056900 8.06e-01
Translation 295 9.32e-02 -0.056800 1.62e-01
PERK regulates gene expression 31 5.87e-01 0.056400 6.91e-01
Processing and activation of SUMO 10 7.60e-01 0.055700 8.35e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 6.21e-01 0.054900 7.22e-01
PI3K Cascade 30 6.07e-01 0.054200 7.09e-01
SUMOylation 166 2.40e-01 -0.052900 3.45e-01
CD28 co-stimulation 33 5.99e-01 -0.052800 7.01e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 80 4.15e-01 0.052700 5.31e-01
RNA Polymerase I Promoter Clearance 66 4.60e-01 0.052600 5.73e-01
RNA Polymerase I Transcription 66 4.60e-01 0.052600 5.73e-01
G2/M Checkpoints 140 2.87e-01 0.052100 3.98e-01
Voltage gated Potassium channels 25 6.54e-01 0.051800 7.48e-01
Synthesis of PIPs at the Golgi membrane 16 7.25e-01 0.050800 8.08e-01
Diseases associated with N-glycosylation of proteins 17 7.17e-01 0.050700 8.03e-01
Mitotic Prometaphase 185 2.37e-01 -0.050400 3.43e-01
Cargo trafficking to the periciliary membrane 47 5.50e-01 0.050400 6.60e-01
Processing of Capped Intronless Pre-mRNA 28 6.53e-01 -0.049100 7.48e-01
FCERI mediated Ca+2 mobilization 89 4.25e-01 -0.049000 5.39e-01
TP53 Regulates Transcription of DNA Repair Genes 61 5.09e-01 -0.048900 6.19e-01
SHC-mediated cascade:FGFR2 12 7.71e-01 -0.048500 8.43e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 6.31e-01 0.047600 7.30e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 6.82e-01 0.047400 7.72e-01
Signaling by NODAL 13 7.71e-01 -0.046600 8.43e-01
Chromatin modifying enzymes 218 2.40e-01 0.046200 3.45e-01
Chromatin organization 218 2.40e-01 0.046200 3.45e-01
Processing of SMDT1 15 7.57e-01 0.046100 8.33e-01
Association of TriC/CCT with target proteins during biosynthesis 37 6.28e-01 0.046000 7.28e-01
FCGR3A-mediated IL10 synthesis 99 4.29e-01 -0.046000 5.43e-01
Binding and Uptake of Ligands by Scavenger Receptors 93 4.44e-01 0.046000 5.56e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 4.67e-01 -0.045900 5.80e-01
mRNA Splicing - Minor Pathway 52 5.69e-01 0.045700 6.75e-01
TRAF3-dependent IRF activation pathway 13 7.76e-01 0.045500 8.46e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 7.25e-01 -0.045500 8.08e-01
Telomere Maintenance 80 4.82e-01 -0.045500 5.96e-01
Reproduction 80 4.86e-01 0.045100 5.99e-01
SUMO E3 ligases SUMOylate target proteins 160 3.29e-01 -0.044700 4.46e-01
Regulation of expression of SLITs and ROBOs 161 3.30e-01 -0.044500 4.46e-01
Signaling by KIT in disease 20 7.31e-01 -0.044400 8.12e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 7.31e-01 -0.044400 8.12e-01
Diseases of metabolism 191 2.93e-01 0.044100 4.04e-01
Deactivation of the beta-catenin transactivating complex 36 6.47e-01 0.044100 7.44e-01
HIV Life Cycle 144 3.61e-01 0.044100 4.74e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 8.02e-01 0.043800 8.69e-01
Defective B4GALT7 causes EDS, progeroid type 11 8.03e-01 -0.043500 8.70e-01
Phosphorylation of the APC/C 20 7.43e-01 0.042300 8.21e-01
DAP12 signaling 28 7.02e-01 0.041800 7.90e-01
O-linked glycosylation 84 5.09e-01 -0.041700 6.19e-01
Vitamin D (calciferol) metabolism 10 8.20e-01 0.041600 8.81e-01
Termination of O-glycan biosynthesis 16 7.74e-01 0.041500 8.45e-01
DNA Replication Pre-Initiation 83 5.15e-01 0.041300 6.26e-01
Signaling by FGFR2 in disease 32 6.86e-01 0.041200 7.76e-01
Glutamate Neurotransmitter Release Cycle 20 7.51e-01 -0.041100 8.27e-01
FCERI mediated MAPK activation 90 5.03e-01 0.040900 6.14e-01
RNA Polymerase III Transcription Termination 23 7.35e-01 -0.040800 8.14e-01
Netrin-1 signaling 40 6.56e-01 0.040700 7.50e-01
Norepinephrine Neurotransmitter Release Cycle 14 7.94e-01 0.040300 8.62e-01
Lewis blood group biosynthesis 13 8.04e-01 0.039800 8.70e-01
Transcriptional Regulation by TP53 352 2.00e-01 0.039800 3.02e-01
Glucagon-type ligand receptors 20 7.61e-01 0.039300 8.35e-01
Ion transport by P-type ATPases 43 6.57e-01 0.039100 7.50e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 5.23e-01 -0.038700 6.32e-01
Amplification of signal from the kinetochores 91 5.23e-01 -0.038700 6.32e-01
mRNA 3'-end processing 56 6.17e-01 -0.038700 7.18e-01
IL-6-type cytokine receptor ligand interactions 12 8.18e-01 0.038400 8.79e-01
Interleukin-2 signaling 11 8.26e-01 0.038300 8.84e-01
Synthesis of DNA 119 4.71e-01 -0.038300 5.84e-01
AURKA Activation by TPX2 72 5.76e-01 -0.038100 6.82e-01
Meiosis 68 5.88e-01 0.038000 6.92e-01
Synthesis of PA 32 7.10e-01 0.038000 7.96e-01
CDC6 association with the ORC:origin complex 11 8.28e-01 -0.037900 8.85e-01
S Phase 161 4.08e-01 -0.037800 5.24e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 5.52e-01 -0.037600 6.61e-01
Formation of Incision Complex in GG-NER 43 6.70e-01 0.037500 7.63e-01
Sulfur amino acid metabolism 22 7.63e-01 0.037100 8.37e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 8.26e-01 0.036700 8.84e-01
Processing of Capped Intron-Containing Pre-mRNA 238 3.40e-01 -0.035900 4.55e-01
Metabolism of water-soluble vitamins and cofactors 110 5.17e-01 -0.035700 6.28e-01
TNFR1-induced NFkappaB signaling pathway 25 7.59e-01 -0.035400 8.35e-01
SUMOylation of DNA methylation proteins 16 8.08e-01 -0.035200 8.72e-01
Cytosolic sensors of pathogen-associated DNA 62 6.36e-01 0.034700 7.34e-01
IRF3-mediated induction of type I IFN 12 8.35e-01 -0.034700 8.92e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 8.24e-01 -0.034400 8.83e-01
Scavenging of heme from plasma 71 6.17e-01 -0.034400 7.18e-01
CLEC7A (Dectin-1) induces NFAT activation 11 8.44e-01 -0.034200 8.95e-01
Mitochondrial protein import 64 6.41e-01 0.033700 7.38e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 7.35e-01 -0.032700 8.14e-01
Diseases of mitotic cell cycle 36 7.35e-01 -0.032700 8.14e-01
Mitotic Spindle Checkpoint 108 5.59e-01 -0.032600 6.66e-01
Activation of SMO 13 8.44e-01 0.031500 8.95e-01
Metabolism of vitamins and cofactors 156 4.99e-01 0.031400 6.11e-01
Processing of DNA double-strand break ends 71 6.48e-01 -0.031300 7.45e-01
Mitotic G1 phase and G1/S transition 148 5.19e-01 0.030700 6.29e-01
G2/M DNA damage checkpoint 68 6.63e-01 -0.030500 7.56e-01
GABA synthesis, release, reuptake and degradation 13 8.49e-01 -0.030400 8.97e-01
Nucleotide-like (purinergic) receptors 13 8.49e-01 0.030400 8.97e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 6.75e-01 -0.030300 7.67e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 8.14e-01 -0.029600 8.76e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 8.14e-01 -0.029600 8.76e-01
Serotonin Neurotransmitter Release Cycle 15 8.43e-01 0.029600 8.95e-01
RNA Polymerase II Transcription Termination 65 6.88e-01 -0.028800 7.77e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 8.46e-01 -0.028100 8.95e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 8.43e-01 -0.027800 8.95e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 8.43e-01 -0.027800 8.95e-01
Neurexins and neuroligins 37 7.74e-01 -0.027300 8.45e-01
Collagen chain trimerization 27 8.10e-01 0.026700 8.73e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 8.63e-01 -0.026700 9.08e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 7.92e-01 0.025400 8.60e-01
DNA Replication 126 6.24e-01 -0.025300 7.24e-01
Ribosomal scanning and start codon recognition 58 7.39e-01 -0.025300 8.17e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 8.43e-01 -0.025000 8.95e-01
Interaction between L1 and Ankyrins 22 8.40e-01 0.024900 8.95e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 8.60e-01 -0.024700 9.07e-01
Class A/1 (Rhodopsin-like receptors) 169 5.81e-01 0.024600 6.86e-01
Visual phototransduction 60 7.45e-01 0.024300 8.22e-01
RUNX2 regulates bone development 24 8.39e-01 -0.024000 8.95e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 8.81e-01 0.023100 9.24e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 8.81e-01 0.023100 9.24e-01
Methylation 12 8.93e-01 -0.022400 9.33e-01
Deposition of new CENPA-containing nucleosomes at the centromere 40 8.08e-01 0.022200 8.72e-01
Nucleosome assembly 40 8.08e-01 0.022200 8.72e-01
Lysosphingolipid and LPA receptors 11 9.05e-01 -0.020900 9.39e-01
APC-Cdc20 mediated degradation of Nek2A 26 8.54e-01 0.020800 9.02e-01
Interleukin-35 Signalling 12 9.03e-01 -0.020200 9.39e-01
Signaling by Retinoic Acid 31 8.45e-01 0.020200 8.95e-01
Translation initiation complex formation 58 7.90e-01 -0.020200 8.59e-01
Class B/2 (Secretin family receptors) 56 7.94e-01 0.020200 8.62e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 9.08e-01 -0.020100 9.41e-01
EML4 and NUDC in mitotic spindle formation 95 7.36e-01 -0.020000 8.15e-01
Regulation of PLK1 Activity at G2/M Transition 87 7.48e-01 -0.019900 8.25e-01
PIWI-interacting RNA (piRNA) biogenesis 24 8.66e-01 0.019900 9.10e-01
Role of LAT2/NTAL/LAB on calcium mobilization 74 7.69e-01 -0.019800 8.42e-01
Dual incision in TC-NER 65 7.87e-01 -0.019400 8.57e-01
RHO GTPases Activate Formins 117 7.21e-01 0.019100 8.05e-01
G0 and Early G1 27 8.65e-01 0.018900 9.10e-01
FGFR2 mutant receptor activation 22 8.82e-01 0.018300 9.24e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 8.87e-01 -0.018300 9.28e-01
Cell Cycle, Mitotic 503 4.89e-01 0.018000 6.02e-01
HATs acetylate histones 93 7.69e-01 -0.017600 8.42e-01
AKT phosphorylates targets in the nucleus 10 9.23e-01 -0.017600 9.51e-01
CRMPs in Sema3A signaling 14 9.13e-01 -0.016900 9.44e-01
Regulation of TP53 Expression and Degradation 36 8.61e-01 -0.016800 9.07e-01
CTLA4 inhibitory signaling 21 8.94e-01 -0.016800 9.33e-01
Anti-inflammatory response favouring Leishmania parasite infection 169 7.09e-01 0.016600 7.96e-01
Leishmania parasite growth and survival 169 7.09e-01 0.016600 7.96e-01
Regulation of innate immune responses to cytosolic DNA 14 9.14e-01 0.016600 9.45e-01
Negative regulators of DDX58/IFIH1 signaling 34 8.71e-01 -0.016100 9.14e-01
Epigenetic regulation of gene expression 103 7.84e-01 0.015700 8.54e-01
HCMV Early Events 74 8.23e-01 0.015000 8.83e-01
Signaling by FGFR3 in disease 13 9.26e-01 0.014800 9.51e-01
Signaling by FGFR3 point mutants in cancer 13 9.26e-01 0.014800 9.51e-01
Cardiac conduction 92 8.06e-01 0.014800 8.72e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 9.05e-01 0.014700 9.39e-01
Keratan sulfate biosynthesis 22 9.05e-01 -0.014700 9.39e-01
Protein-protein interactions at synapses 58 8.47e-01 0.014700 8.96e-01
CASP8 activity is inhibited 11 9.35e-01 -0.014300 9.52e-01
Dimerization of procaspase-8 11 9.35e-01 -0.014300 9.52e-01
Regulation by c-FLIP 11 9.35e-01 -0.014300 9.52e-01
Cell Cycle Checkpoints 260 6.92e-01 0.014300 7.81e-01
FOXO-mediated transcription of cell cycle genes 15 9.24e-01 0.014300 9.51e-01
Regulation of necroptotic cell death 14 9.26e-01 -0.014300 9.51e-01
Organelle biogenesis and maintenance 269 6.88e-01 -0.014200 7.77e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 9.27e-01 0.014200 9.51e-01
Mitochondrial translation termination 91 8.18e-01 -0.014000 8.79e-01
mRNA decay by 5' to 3' exoribonuclease 15 9.25e-01 -0.014000 9.51e-01
Downstream signaling of activated FGFR2 19 9.17e-01 0.013700 9.46e-01
Mitochondrial translation elongation 91 8.28e-01 -0.013200 8.85e-01
Signaling by ROBO receptors 201 7.52e-01 -0.012900 8.28e-01
Nicotinate metabolism 25 9.12e-01 -0.012800 9.44e-01
GPCR ligand binding 235 7.37e-01 0.012700 8.15e-01
Glutathione synthesis and recycling 10 9.47e-01 0.012000 9.62e-01
Transcription of E2F targets under negative control by DREAM complex 19 9.30e-01 0.011600 9.52e-01
DNA Damage Recognition in GG-NER 38 9.01e-01 -0.011600 9.38e-01
Deadenylation-dependent mRNA decay 53 8.88e-01 -0.011200 9.28e-01
Dopamine Neurotransmitter Release Cycle 20 9.31e-01 0.011200 9.52e-01
Tight junction interactions 18 9.35e-01 0.011200 9.52e-01
TNF signaling 42 9.01e-01 0.011100 9.38e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 9.52e-01 0.011100 9.64e-01
Defective EXT2 causes exostoses 2 10 9.52e-01 0.011100 9.64e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.34e-01 0.010700 9.52e-01
Regulation of FZD by ubiquitination 15 9.44e-01 -0.010500 9.60e-01
Cell Cycle 625 6.60e-01 -0.010300 7.53e-01
FRS-mediated FGFR2 signaling 14 9.47e-01 0.010200 9.62e-01
Synthesis of PIPs at the early endosome membrane 16 9.46e-01 -0.009840 9.61e-01
Nucleotide Excision Repair 110 8.60e-01 -0.009710 9.07e-01
Signaling by BMP 21 9.44e-01 -0.008810 9.60e-01
Kinesins 39 9.28e-01 0.008350 9.51e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 9.13e-01 -0.008230 9.44e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 9.00e-01 -0.008230 9.38e-01
Mitochondrial translation initiation 91 8.94e-01 -0.008110 9.33e-01
RMTs methylate histone arginines 37 9.33e-01 0.008010 9.52e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 9.63e-01 0.007440 9.72e-01
Defective B3GAT3 causes JDSSDHD 11 9.66e-01 -0.007380 9.75e-01
Resolution of Sister Chromatid Cohesion 104 9.00e-01 -0.007100 9.38e-01
Metabolism of amino acids and derivatives 326 8.44e-01 -0.006360 8.95e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 9.57e-01 -0.006090 9.67e-01
PECAM1 interactions 12 9.71e-01 -0.005960 9.79e-01
Diseases of glycosylation 109 9.17e-01 -0.005800 9.46e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 9.57e-01 0.005560 9.67e-01
mRNA Splicing - Major Pathway 179 9.18e-01 -0.004470 9.46e-01
Synaptic adhesion-like molecules 15 9.77e-01 0.004340 9.82e-01
Gene Silencing by RNA 88 9.54e-01 -0.003580 9.66e-01
Nuclear Receptor transcription pathway 38 9.71e-01 0.003360 9.79e-01
G1/S Transition 130 9.54e-01 0.002910 9.66e-01
Regulation of TP53 Degradation 35 9.81e-01 0.002380 9.84e-01
Regulation of Complement cascade 95 9.72e-01 0.002070 9.79e-01
Complement cascade 99 9.76e-01 0.001730 9.82e-01
mRNA Splicing 187 9.78e-01 -0.001160 9.83e-01
DCC mediated attractive signaling 13 9.94e-01 -0.001140 9.95e-01
SLC transporter disorders 77 9.89e-01 0.000929 9.92e-01
Ion homeostasis 41 9.92e-01 -0.000892 9.94e-01
Mitochondrial translation 97 9.93e-01 0.000502 9.95e-01
Glyoxylate metabolism and glycine degradation 24 9.98e-01 -0.000366 9.98e-01


Detailed Gene set reports



IRAK4 deficiency (TLR2/4)

513
set IRAK4 deficiency (TLR2/4)
setSize 10
pANOVA 8.8e-07
s.dist 0.898
p.adjustANOVA 1.12e-05



Top enriched genes

GeneID Gene Rank
CD36 9486
CD14 9164
TLR2 9069
TLR1 9041
TLR4 8981
TLR6 8931
LY96 8871
MYD88 8091
BTK 7156
TIRAP 5700

Click HERE to show all gene set members

GeneID Gene Rank
CD36 9486
CD14 9164
TLR2 9069
TLR1 9041
TLR4 8981
TLR6 8931
LY96 8871
MYD88 8091
BTK 7156
TIRAP 5700


MyD88 deficiency (TLR2/4)

686
set MyD88 deficiency (TLR2/4)
setSize 10
pANOVA 8.8e-07
s.dist 0.898
p.adjustANOVA 1.12e-05



Top enriched genes

GeneID Gene Rank
CD36 9486
CD14 9164
TLR2 9069
TLR1 9041
TLR4 8981
TLR6 8931
LY96 8871
MYD88 8091
BTK 7156
TIRAP 5700

Click HERE to show all gene set members

GeneID Gene Rank
CD36 9486
CD14 9164
TLR2 9069
TLR1 9041
TLR4 8981
TLR6 8931
LY96 8871
MYD88 8091
BTK 7156
TIRAP 5700


alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

1331
set alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize 12
pANOVA 2.31e-06
s.dist 0.787
p.adjustANOVA 2.48e-05



Top enriched genes

GeneID Gene Rank
ACSL1 9334
ACOX1 8954
HSD17B4 8874
ELOVL3 8667
ACAA1 8398
ACOT8 8129
FADS1 7822
ABCD1 7330
ELOVL1 7175
ELOVL5 6074
SCP2 4477
FADS2 1658

Click HERE to show all gene set members

GeneID Gene Rank
ACSL1 9334
ACOX1 8954
HSD17B4 8874
ELOVL3 8667
ACAA1 8398
ACOT8 8129
FADS1 7822
ABCD1 7330
ELOVL1 7175
ELOVL5 6074
SCP2 4477
FADS2 1658


alpha-linolenic acid (ALA) metabolism

1332
set alpha-linolenic acid (ALA) metabolism
setSize 12
pANOVA 2.31e-06
s.dist 0.787
p.adjustANOVA 2.48e-05



Top enriched genes

GeneID Gene Rank
ACSL1 9334
ACOX1 8954
HSD17B4 8874
ELOVL3 8667
ACAA1 8398
ACOT8 8129
FADS1 7822
ABCD1 7330
ELOVL1 7175
ELOVL5 6074
SCP2 4477
FADS2 1658

Click HERE to show all gene set members

GeneID Gene Rank
ACSL1 9334
ACOX1 8954
HSD17B4 8874
ELOVL3 8667
ACAA1 8398
ACOT8 8129
FADS1 7822
ABCD1 7330
ELOVL1 7175
ELOVL5 6074
SCP2 4477
FADS2 1658


Translocation of ZAP-70 to Immunological synapse

1278
set Translocation of ZAP-70 to Immunological synapse
setSize 24
pANOVA 2.76e-10
s.dist -0.744
p.adjustANOVA 8.37e-09



Top enriched genes

GeneID Gene Rank
CD247 -12295
HLA-DPA1 -12271
HLA-DPB1 -12203
HLA-DRA -12007
TRBC1 -11859
ZAP70 -11833
HLA-DQA1 -11763
LCK -11492
CD3G -11409
CD3D -11094
CD3E -11042
TRAC -10981
TRBV12-3 -10279
TRAV19 -10023
TRBV7-9 -9564
HLA-DQB2 -9390
TRAV8-4 -9384
TRAV29DV5 -9334
HLA-DRB1 -8159
HLA-DQB1 -5703

Click HERE to show all gene set members

GeneID Gene Rank
CD247 -12295
HLA-DPA1 -12271
HLA-DPB1 -12203
HLA-DRA -12007
TRBC1 -11859
ZAP70 -11833
HLA-DQA1 -11763
LCK -11492
CD3G -11409
CD3D -11094
CD3E -11042
TRAC -10981
TRBV12-3 -10279
TRAV19 -10023
TRBV7-9 -9564
HLA-DQB2 -9390
TRAV8-4 -9384
TRAV29DV5 -9334
HLA-DRB1 -8159
HLA-DQB1 -5703
CD4 -5320
HLA-DRB5 -5140
HLA-DQA2 -4793
PTPN22 -1112


Regulation of TLR by endogenous ligand

968
set Regulation of TLR by endogenous ligand
setSize 11
pANOVA 2.02e-05
s.dist 0.742
p.adjustANOVA 0.000148



Top enriched genes

GeneID Gene Rank
S100A9 9562
S100A8 9560
CD36 9486
CD14 9164
TLR2 9069
TLR1 9041
TLR4 8981
TLR6 8931
LY96 8871
HMGB1 -200
S100A1 -8267

Click HERE to show all gene set members

GeneID Gene Rank
S100A9 9562
S100A8 9560
CD36 9486
CD14 9164
TLR2 9069
TLR1 9041
TLR4 8981
TLR6 8931
LY96 8871
HMGB1 -200
S100A1 -8267


Hyaluronan uptake and degradation

505
set Hyaluronan uptake and degradation
setSize 12
pANOVA 9.15e-06
s.dist 0.739
p.adjustANOVA 7.52e-05



Top enriched genes

GeneID Gene Rank
CHP1 9263
LYVE1 9187
HYAL2 9156
HEXB 8749
CD44 8314
SLC9A1 8016
GUSB 7454
STAB2 5599
HYAL3 5235
HYAL1 4297
HMMR 4051
HEXA 1274

Click HERE to show all gene set members

GeneID Gene Rank
CHP1 9263
LYVE1 9187
HYAL2 9156
HEXB 8749
CD44 8314
SLC9A1 8016
GUSB 7454
STAB2 5599
HYAL3 5235
HYAL1 4297
HMMR 4051
HEXA 1274


Erythrocytes take up carbon dioxide and release oxygen

345
set Erythrocytes take up carbon dioxide and release oxygen
setSize 11
pANOVA 3.56e-05
s.dist 0.72
p.adjustANOVA 0.00024



Top enriched genes

GeneID Gene Rank
CYB5R1 9511
CA1 9414
SLC4A1 9198
HBA1 9095
CYB5R2 8623
HBB 8528
CA4 8447
CYB5R4 8433
AQP1 7352
CA2 3565
CYB5RL -10650

Click HERE to show all gene set members

GeneID Gene Rank
CYB5R1 9511
CA1 9414
SLC4A1 9198
HBA1 9095
CYB5R2 8623
HBB 8528
CA4 8447
CYB5R4 8433
AQP1 7352
CA2 3565
CYB5RL -10650


O2/CO2 exchange in erythrocytes

765
set O2/CO2 exchange in erythrocytes
setSize 11
pANOVA 3.56e-05
s.dist 0.72
p.adjustANOVA 0.00024



Top enriched genes

GeneID Gene Rank
CYB5R1 9511
CA1 9414
SLC4A1 9198
HBA1 9095
CYB5R2 8623
HBB 8528
CA4 8447
CYB5R4 8433
AQP1 7352
CA2 3565
CYB5RL -10650

Click HERE to show all gene set members

GeneID Gene Rank
CYB5R1 9511
CA1 9414
SLC4A1 9198
HBA1 9095
CYB5R2 8623
HBB 8528
CA4 8447
CYB5R4 8433
AQP1 7352
CA2 3565
CYB5RL -10650


Uptake and function of anthrax toxins

1306
set Uptake and function of anthrax toxins
setSize 10
pANOVA 0.000113
s.dist 0.705
p.adjustANOVA 0.000634



Top enriched genes

GeneID Gene Rank
FURIN 9162
MAP2K6 9010
MAP2K1 8960
MAP2K3 8785
ANTXR2 7435
MAP2K4 6948
MAP2K2 6906
PDCD6IP 6585
MAP2K7 1647
CALM1 -2048

Click HERE to show all gene set members

GeneID Gene Rank
FURIN 9162
MAP2K6 9010
MAP2K1 8960
MAP2K3 8785
ANTXR2 7435
MAP2K4 6948
MAP2K2 6906
PDCD6IP 6585
MAP2K7 1647
CALM1 -2048


WNT5A-dependent internalization of FZD2, FZD5 and ROR2

1324
set WNT5A-dependent internalization of FZD2, FZD5 and ROR2
setSize 11
pANOVA 9.66e-05
s.dist 0.679
p.adjustANOVA 0.000559



Top enriched genes

GeneID Gene Rank
FZD5 9561
CLTC 9056
AP2M1 8673
CLTA 8402
AP2S1 8080
AP2A2 7360
AP2A1 6628
FZD2 6552
CLTB 6195
ROR1 -1182
AP2B1 -2748

Click HERE to show all gene set members

GeneID Gene Rank
FZD5 9561
CLTC 9056
AP2M1 8673
CLTA 8402
AP2S1 8080
AP2A2 7360
AP2A1 6628
FZD2 6552
CLTB 6195
ROR1 -1182
AP2B1 -2748


p130Cas linkage to MAPK signaling for integrins

1343
set p130Cas linkage to MAPK signaling for integrins
setSize 11
pANOVA 0.000139
s.dist 0.663
p.adjustANOVA 0.00075



Top enriched genes

GeneID Gene Rank
ITGA2B 8942
CRK 8941
APBB1IP 8849
TLN1 8554
ITGB3 8367
FN1 8294
RAP1A 7319
VWF 6607
PTK2 4506
RAP1B 3331
SRC -9011

Click HERE to show all gene set members

GeneID Gene Rank
ITGA2B 8942
CRK 8941
APBB1IP 8849
TLN1 8554
ITGB3 8367
FN1 8294
RAP1A 7319
VWF 6607
PTK2 4506
RAP1B 3331
SRC -9011


Advanced glycosylation endproduct receptor signaling

61
set Advanced glycosylation endproduct receptor signaling
setSize 12
pANOVA 9.45e-05
s.dist 0.651
p.adjustANOVA 0.000551



Top enriched genes

GeneID Gene Rank
S100A12 9567
APP 9123
MAPK3 9078
LGALS3 8619
CAPZA2 8521
CAPZA1 8165
MAPK1 7520
DDOST 6972
PRKCSH 5300
AGER 1309
HMGB1 -200
S100B -5025

Click HERE to show all gene set members

GeneID Gene Rank
S100A12 9567
APP 9123
MAPK3 9078
LGALS3 8619
CAPZA2 8521
CAPZA1 8165
MAPK1 7520
DDOST 6972
PRKCSH 5300
AGER 1309
HMGB1 -200
S100B -5025


Unwinding of DNA

1304
set Unwinding of DNA
setSize 12
pANOVA 0.000104
s.dist -0.647
p.adjustANOVA 0.000598



Top enriched genes

GeneID Gene Rank
MCM3 -12163
MCM7 -12004
MCM8 -10989
GINS3 -10524
GINS4 -10394
MCM6 -9941
MCM4 -8819
MCM5 -7430
MCM2 -7316
GINS2 -4841
GINS1 -4435
CDC45 -2683

Click HERE to show all gene set members

GeneID Gene Rank
MCM3 -12163
MCM7 -12004
MCM8 -10989
GINS3 -10524
GINS4 -10394
MCM6 -9941
MCM4 -8819
MCM5 -7430
MCM2 -7316
GINS2 -4841
GINS1 -4435
CDC45 -2683


RNA Polymerase I Promoter Opening

902
set RNA Polymerase I Promoter Opening
setSize 19
pANOVA 2.76e-06
s.dist 0.621
p.adjustANOVA 2.84e-05



Top enriched genes

GeneID Gene Rank
H2AJ 9418.0
H2BC21 9368.0
H2BC12 9178.0
MAPK3 9078.0
H3-3A 8754.0
H2BC5 8163.0
H2BC11 8076.0
H2AC6 8070.0
H2BC4 7549.0
H2BC17 7502.0
H3C15 6780.5
MBD2 6373.0
H2AZ1 6126.0
H2BC9 5461.0
H2BC15 5458.0
H2AC20 5039.0
H2AZ2 -1266.0
H2BU1 -6519.0
UBTF -9662.0

Click HERE to show all gene set members

GeneID Gene Rank
H2AJ 9418.0
H2BC21 9368.0
H2BC12 9178.0
MAPK3 9078.0
H3-3A 8754.0
H2BC5 8163.0
H2BC11 8076.0
H2AC6 8070.0
H2BC4 7549.0
H2BC17 7502.0
H3C15 6780.5
MBD2 6373.0
H2AZ1 6126.0
H2BC9 5461.0
H2BC15 5458.0
H2AC20 5039.0
H2AZ2 -1266.0
H2BU1 -6519.0
UBTF -9662.0


RHO GTPases Activate WASPs and WAVEs

889
set RHO GTPases Activate WASPs and WAVEs
setSize 35
pANOVA 5.3e-10
s.dist 0.606
p.adjustANOVA 1.54e-08



Top enriched genes

GeneID Gene Rank
WASF1 9568
GRB2 9320
ARPC1B 9303
CYFIP1 9270
MAPK3 9078
ACTB 9060
ARPC1A 8923
RAC1 8720
ACTG1 8671
ARPC5 8653
WAS 8596
WASF2 8373
ARPC3 8309
ACTR3 7888
ACTR2 7827
ARPC4 7605
NCKAP1 7562
CDC42 7539
MAPK1 7520
NCKAP1L 7516

Click HERE to show all gene set members

GeneID Gene Rank
WASF1 9568
GRB2 9320
ARPC1B 9303
CYFIP1 9270
MAPK3 9078
ACTB 9060
ARPC1A 8923
RAC1 8720
ACTG1 8671
ARPC5 8653
WAS 8596
WASF2 8373
ARPC3 8309
ACTR3 7888
ACTR2 7827
ARPC4 7605
NCKAP1 7562
CDC42 7539
MAPK1 7520
NCKAP1L 7516
ARPC2 7449
BTK 7156
ABI1 7154
BRK1 7085
WASF3 6915
WIPF2 5769
PTK2 4506
WIPF1 581
NCKIPSD 320
WASL 283
ABL1 229
BAIAP2 -179
CYFIP2 -10387
ABI2 -10893
NCK1 -11488


ROS and RNS production in phagocytes

925
set ROS and RNS production in phagocytes
setSize 31
pANOVA 7.98e-09
s.dist 0.598
p.adjustANOVA 1.75e-07



Top enriched genes

GeneID Gene Rank
ATP6V0A1 9483
NCF4 9365
ATP6V1A 9301
ATP6V0D1 9298
NCF2 9209
SLC11A1 9152
ATP6V1D 9118
ATP6V0C 9113
ATP6V1B2 9005
CYBB 9000
ATP6V0B 8701
ATP6V0E1 8662
ATP6V1C1 8628
ATP6V1H 8119
ATP6V1E1 8107
NCF1 7433
MPO 7364
TCIRG1 7266
CYBA 6952
LPO 6576

Click HERE to show all gene set members

GeneID Gene Rank
ATP6V0A1 9483
NCF4 9365
ATP6V1A 9301
ATP6V0D1 9298
NCF2 9209
SLC11A1 9152
ATP6V1D 9118
ATP6V0C 9113
ATP6V1B2 9005
CYBB 9000
ATP6V0B 8701
ATP6V0E1 8662
ATP6V1C1 8628
ATP6V1H 8119
ATP6V1E1 8107
NCF1 7433
MPO 7364
TCIRG1 7266
CYBA 6952
LPO 6576
ATP6V1F 5949
ATP6V1E2 5776
RAC2 5238
HVCN1 4848
ATP6V1G1 3989
NOS1 1401
NOS3 -1718
ATP6V1C2 -2222
ATP6V1G2 -9275
ATP6V0E2 -11475
ATP6V0A2 -12193


Neutrophil degranulation

736
set Neutrophil degranulation
setSize 458
pANOVA 3.42e-103
s.dist 0.585
p.adjustANOVA 4.67e-100



Top enriched genes

GeneID Gene Rank
S100A12 9567
S100A9 9562
S100A8 9560
RNASE2 9559
MCEMP1 9558
CTSA 9555
SIRPA 9550
IDH1 9547
CR1 9545
CD93 9540
CD177 9539
MGST1 9532
BST1 9529
CREG1 9521
HP 9518
GCA 9492
TIMP2 9488
CD36 9486
ATP6V0A1 9483
PYGL 9481

Click HERE to show all gene set members

GeneID Gene Rank
S100A12 9567
S100A9 9562
S100A8 9560
RNASE2 9559
MCEMP1 9558
CTSA 9555
SIRPA 9550
IDH1 9547
CR1 9545
CD93 9540
CD177 9539
MGST1 9532
BST1 9529
CREG1 9521
HP 9518
GCA 9492
TIMP2 9488
CD36 9486
ATP6V0A1 9483
PYGL 9481
PGAM1 9478
CTSD 9475
SERPINB1 9466
ITGAM 9453
LAMTOR1 9450
DOK3 9437
ANPEP 9427
HK3 9425
CKAP4 9420
PGM2 9410
SIGLEC9 9408
PKM 9395
PTAFR 9392
QPCT 9387
FPR1 9379
CDA 9374
MMP9 9370
SDCBP 9367
IMPDH1 9364
PADI2 9362
RAB31 9353
MNDA 9336
CD63 9330
VAT1 9326
GNS 9309
CTSB 9304
QSOX1 9302
LTA4H 9300
GPR84 9292
AGPAT2 9286
FPR2 9282
GRN 9275
ALDOA 9274
CYFIP1 9270
CYSTM1 9266
PLD1 9245
RETN 9241
RAB3D 9231
MAPK14 9219
MGAM 9213
FCAR 9211
C5AR1 9205
SERPINA1 9179
FCN1 9165
CD14 9164
CD55 9157
CLEC4D 9154
SLC11A1 9152
VNN1 9151
TRPM2 9149
SLC2A3 9144
OSCAR 9143
GYG1 9141
NCSTN 9139
CAT 9137
TOM1 9133
NFAM1 9119
ATP6V1D 9118
ATP6V0C 9113
ALOX5 9088
NEU1 9084
VAPA 9073
APAF1 9072
TLR2 9069
BRI3 9064
SELL 9023
CRISPLD2 9022
PRKCD 9012
S100A11 9007
GM2A 9002
CTSZ 9001
CYBB 9000
PRDX6 8986
SERPINB10 8984
TNFAIP6 8970
RAB10 8915
ITGB2 8908
ARG1 8895
LRG1 8891
CYB5R3 8887
FCGR2A 8858
AMPD3 8841
GSN 8805
LAMP2 8803
LILRB3 8793
RAB7A 8775
HEXB 8749
DNAJC5 8746
PYCARD 8734
RAC1 8720
ADAM10 8705
FTL 8698
RAB5C 8688
TOLLIP 8668
PDXK 8664
ARPC5 8653
GLB1 8652
MMP25 8630
LGALS3 8619
CAPN1 8613
PLAC8 8610
ALAD 8605
SNAP23 8578
DNASE1L1 8575
CLEC5A 8574
S100P 8552
RHOG 8544
PSMB7 8535
HBB 8528
PNP 8525
RAB27A 8504
MMP8 8494
PLAUR 8490
ALDH3B1 8489
HEBP2 8478
DNAJC3 8468
P2RX1 8444
DERA 8442
ATP11A 8431
HPSE 8427
TMBIM1 8425
ANXA2 8424
CD68 8421
ADGRG3 8417
GLA 8404
ACAA1 8398
FGR 8397
SIGLEC5 8382
GMFG 8379
ASAH1 8368
CAB39 8364
MOSPD2 8317
CD44 8314
ARL8A 8305
CTSS 8300
CPPED1 8275
RAB3A 8247
RAB6A 8223
PRCP 8222
RHOA 8218
CAP1 8200
FUCA2 8195
IQGAP1 8189
HSPA1A 8178
DNAJC13 8151
FCER1G 8143
PLEKHO2 8138
CD33 8128
ORM1 8082
C3AR1 8067
ATG7 8065
PGLYRP1 8051
LILRB2 8033
GAA 8031
OLFM4 8008
ANO6 8005
TMEM30A 7995
KCMF1 7951
CD53 7939
ATP6AP2 7934
COMMD9 7912
RAB18 7893
TRAPPC1 7887
PSMD6 7881
PGRMC1 7863
DBNL 7859
PSEN1 7843
PTPRJ 7833
ACTR2 7827
CANT1 7826
CMTM6 7818
GLIPR1 7804
SIRPB1 7802
LCN2 7752
COTL1 7749
RNASE3 7744
PECAM1 7743
LAMTOR2 7704
LAMTOR3 7692
UNC13D 7687
ACTR10 7652
DOCK2 7631
LAMP1 7613
TYROBP 7587
CRISP3 7552
OSTF1 7522
MAPK1 7520
NCKAP1L 7516
FUCA1 7508
NAPRT 7506
PSMD2 7470
GUSB 7454
ROCK1 7445
ITGAX 7429
COPB1 7399
VCL 7380
ARSB 7373
MPO 7364
MANBA 7361
AP2A2 7360
TUBB4B 7341
GDI2 7337
RAP1A 7319
ELANE 7303
LAIR1 7301
PSMD1 7283
IGF2R 7270
TCIRG1 7266
CFP 7228
LYZ 7202
FOLR3 7200
GALNS 7183
NBEAL2 7161
SURF4 7147
MVP 7108
RAB14 7090
ATP8B4 7041
CEACAM1 7034
PAFAH1B2 7026
TSPAN14 7007
METTL7A 6999
DYNC1LI1 6992
DDOST 6972
STOM 6963
CEACAM3 6960
VCP 6955
CYBA 6952
PSAP 6909
CSTB 6856
MAN2B1 6854
CXCR1 6844
PRTN3 6822
RAB5B 6801
AP1M1 6788
ERP44 6782
YPEL5 6725
CNN2 6719
DDX3X 6710
CD58 6665
CCT8 6640
HSPA6 6580
BPI 6538
PSMD12 6537
AOC1 6531
HSPA1B 6495
ARMC8 6440
SNAP29 6418
SRP14 6411
GGH 6387
NFKB1 6367
CTSH 6356
PSMD11 6296
ARHGAP9 6288
DEGS1 6287
IQGAP2 6286
TCN1 6281
C6orf120 6267
GPI 6246
TICAM2 6244
NDUFC2 6199
DEFA4 6193
LTF 6182
PTPN6 6176
ATP11B 6172
CHIT1 6164
ITGAV 6133
VPS35L 6132
FABP5 6123
DYNLL1 6049
PPBP 6029
PSMD7 6017
PDAP1 6001
PSMD13 5991
CD59 5964
CPNE3 5955
DEFA1 5953
RNASET2 5952
PGM1 5947
IST1 5945
TNFRSF1B 5916
CXCR2 5851
BIN2 5796
SERPINB6 5793
PTX3 5775
STBD1 5745
ADAM8 5709
FAF2 5634
A1BG 5617
CXCL1 5516
NPC2 5468
XRCC5 5452
PSMA2 5433
SLPI 5421
RAB24 5415
NRAS 5411
TARM1 5384
AZU1 5376
DGAT1 5367
VAMP8 5284
CTSG 5224
ACLY 5214
PTPRN2 5203
SIGLEC14 5150
PLAU 4978
CEACAM8 4935
FTH1 4867
HVCN1 4848
STING1 4844
ABCA13 4730
CEACAM6 4720
CAMP 4713
PSMD3 4693
RAP2C 4677
KRT1 4597
CLEC12A 4566
DYNLT1 4474
B4GALT1 4354
FCGR3B 4340
GHDC 4207
GOLGA7 4109
CSNK2B 3987
SLC15A4 3867
STK11IP 3634
ARSA 3499
SLCO4C1 3445
PSMB1 3422
RAP1B 3331
RAB4B 3231
SLC44A2 2733
PSMD14 2703
MAGT1 2698
PSMC2 2696
CTSC 2547
KPNB1 2491
OLR1 2447
MS4A3 2372
MLEC 2315
PTPRC 2253
CST3 2157
SVIP 2123
SLC2A5 2109
PSMC3 2018
CFD 2016
GSDMD 1976
HGSNAT 1871
NME2 1853
SCAMP1 1834
HSP90AA1 1348
NHLRC3 1267
APEH 1061
HLA-C 1032
NFASC 884
HLA-B 658
TXNDC5 548
RAB44 540
TMEM179B 497
PYGB 484
LRMP 447
ADGRE3 396
EEF2 289
FGL2 275
GSTP1 197
FRK 94
KCNAB2 0
PRDX4 -86
HMGB1 -200
CHI3L1 -634
RAP2B -691
DIAPH1 -704
DSP -1230
COMMD3 -1441
LRRC7 -2007
ILF2 -2037
CD300A -2076
UBR4 -2107
ADGRE5 -2501
HLA-A -2578
ORM2 -2594
APRT -2769
AGL -3177
PFKL -3284
ALDOC -3343
MME -3410
CPNE1 -3422
STK10 -3811
MIF -3828
HLA-H -3892
SLC27A2 -3903
PA2G4 -3965
AGA -4398
XRCC6 -4475
DPP7 -4544
EPX -4583
SYNGR1 -4703
PIGR -4739
EEF1A1 -5073
JUP -5541
PSMA5 -6154
RAB9B -6471
CAND1 -6550
DSC1 -6597
HSP90AB1 -6702
PTGES2 -6796
PPIA -6900
B2M -7019
TUBB -7078
HRNR -7225
BST2 -7533
LPCAT1 -7557
PTPRB -7737
DYNC1H1 -7822
HUWE1 -8044
TMEM63A -8437
CDK13 -8535
CCT2 -8727
PPIE -8762
CRACR2A -9184
CEP290 -9354
IMPDH2 -9608
ENPP4 -9810
ATAD3B -9936
ORMDL3 -9994
TMC6 -10352
ACTR1B -10368
HSPA8 -10913
DSN1 -10945
ITGAL -11015
SPTAN1 -11438
FRMPD3 -11446
TBC1D10C -11564
NIT2 -11684
ATP8A1 -11780
HMOX2 -11783
RAB37 -11814
CLEC4C -11862
CD47 -12112
C3 -12243
RHOF -12291


PD-1 signaling

779
set PD-1 signaling
setSize 28
pANOVA 1.17e-07
s.dist -0.578
p.adjustANOVA 1.97e-06



Top enriched genes

GeneID Gene Rank
CD247 -12295
HLA-DPA1 -12271
HLA-DPB1 -12203
HLA-DRA -12007
TRBC1 -11859
HLA-DQA1 -11763
LCK -11492
CD3G -11409
CD3D -11094
CD3E -11042
TRAC -10981
TRBV12-3 -10279
TRAV19 -10023
TRBV7-9 -9564
HLA-DQB2 -9390
TRAV8-4 -9384
TRAV29DV5 -9334
HLA-DRB1 -8159
PDCD1 -6963
CD274 -6803

Click HERE to show all gene set members

GeneID Gene Rank
CD247 -12295
HLA-DPA1 -12271
HLA-DPB1 -12203
HLA-DRA -12007
TRBC1 -11859
HLA-DQA1 -11763
LCK -11492
CD3G -11409
CD3D -11094
CD3E -11042
TRAC -10981
TRBV12-3 -10279
TRAV19 -10023
TRBV7-9 -9564
HLA-DQB2 -9390
TRAV8-4 -9384
TRAV29DV5 -9334
HLA-DRB1 -8159
PDCD1 -6963
CD274 -6803
HLA-DQB1 -5703
CD4 -5320
HLA-DRB5 -5140
HLA-DQA2 -4793
PDCD1LG2 -3315
CSK 5285
PTPN11 5383
PTPN6 6176


GRB2:SOS provides linkage to MAPK signaling for Integrins

434
set GRB2:SOS provides linkage to MAPK signaling for Integrins
setSize 12
pANOVA 0.000527
s.dist 0.578
p.adjustANOVA 0.0024



Top enriched genes

GeneID Gene Rank
GRB2 9320
ITGA2B 8942
APBB1IP 8849
TLN1 8554
ITGB3 8367
FN1 8294
RAP1A 7319
VWF 6607
PTK2 4506
RAP1B 3331
SOS1 -5714
SRC -9011

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 9320
ITGA2B 8942
APBB1IP 8849
TLN1 8554
ITGB3 8367
FN1 8294
RAP1A 7319
VWF 6607
PTK2 4506
RAP1B 3331
SOS1 -5714
SRC -9011


Insulin receptor recycling

540
set Insulin receptor recycling
setSize 21
pANOVA 6.66e-06
s.dist 0.568
p.adjustANOVA 5.86e-05



Top enriched genes

GeneID Gene Rank
ATP6V0A1 9483
ATP6V1A 9301
ATP6V0D1 9298
ATP6V1D 9118
ATP6V0C 9113
ATP6V1B2 9005
ATP6V0B 8701
ATP6V0E1 8662
ATP6V1C1 8628
ATP6V1H 8119
ATP6V1E1 8107
INSR 8103
ATP6AP1 8035
TCIRG1 7266
ATP6V1F 5949
ATP6V1E2 5776
ATP6V1G1 3989
ATP6V1C2 -2222
ATP6V1G2 -9275
ATP6V0E2 -11475

Click HERE to show all gene set members

GeneID Gene Rank
ATP6V0A1 9483
ATP6V1A 9301
ATP6V0D1 9298
ATP6V1D 9118
ATP6V0C 9113
ATP6V1B2 9005
ATP6V0B 8701
ATP6V0E1 8662
ATP6V1C1 8628
ATP6V1H 8119
ATP6V1E1 8107
INSR 8103
ATP6AP1 8035
TCIRG1 7266
ATP6V1F 5949
ATP6V1E2 5776
ATP6V1G1 3989
ATP6V1C2 -2222
ATP6V1G2 -9275
ATP6V0E2 -11475
ATP6V0A2 -12193


Retrograde neurotrophin signalling

1012
set Retrograde neurotrophin signalling
setSize 12
pANOVA 0.000674
s.dist 0.567
p.adjustANOVA 0.00292



Top enriched genes

GeneID Gene Rank
CLTC 9056
AP2M1 8673
CLTA 8402
AP2S1 8080
AP2A2 7360
DNM3 7167
AP2A1 6628
DNM2 6163
DNM1 3526
DNAL4 3391
AP2B1 -2748
NTRK1 -7791

Click HERE to show all gene set members

GeneID Gene Rank
CLTC 9056
AP2M1 8673
CLTA 8402
AP2S1 8080
AP2A2 7360
DNM3 7167
AP2A1 6628
DNM2 6163
DNM1 3526
DNAL4 3391
AP2B1 -2748
NTRK1 -7791


Signaling by Leptin

1104
set Signaling by Leptin
setSize 10
pANOVA 0.00199
s.dist 0.565
p.adjustANOVA 0.00721



Top enriched genes

GeneID Gene Rank
SOCS3 9526
IRS2 8323
STAT3 8152
STAT5B 7011
STAT5A 6983
LEPR 6590
PTPN11 5383
JAK2 2599
IRS1 1806
SH2B1 -8341

Click HERE to show all gene set members

GeneID Gene Rank
SOCS3 9526
IRS2 8323
STAT3 8152
STAT5B 7011
STAT5A 6983
LEPR 6590
PTPN11 5383
JAK2 2599
IRS1 1806
SH2B1 -8341


Dissolution of Fibrin Clot

301
set Dissolution of Fibrin Clot
setSize 12
pANOVA 0.000734
s.dist 0.563
p.adjustANOVA 0.00313



Top enriched genes

GeneID Gene Rank
SERPINB2 9491
SERPINB8 9181
PLAUR 8490
ANXA2 8424
SERPINE1 7580
S100A10 6784
SERPINE2 6506
SERPINB6 5793
PLAU 4978
PLAT -1233
PLG -1998
SERPINF2 -6601

Click HERE to show all gene set members

GeneID Gene Rank
SERPINB2 9491
SERPINB8 9181
PLAUR 8490
ANXA2 8424
SERPINE1 7580
S100A10 6784
SERPINE2 6506
SERPINB6 5793
PLAU 4978
PLAT -1233
PLG -1998
SERPINF2 -6601


Detoxification of Reactive Oxygen Species

279
set Detoxification of Reactive Oxygen Species
setSize 32
pANOVA 3.93e-08
s.dist 0.561
p.adjustANOVA 7.65e-07



Top enriched genes

GeneID Gene Rank
GPX1 9380
PRDX3 9378
NCF4 9365
GSR 9256
NCF2 9209
CAT 9137
CYBB 9000
PRDX6 8986
ERO1A 8853
PRDX5 8612
P4HB 8452
TXN 8414
TXNRD1 8303
TXNRD2 7556
NCF1 7433
PRDX1 7104
CYBA 6952
TXN2 4728
SOD2 4458
ATOX1 4439

Click HERE to show all gene set members

GeneID Gene Rank
GPX1 9380
PRDX3 9378
NCF4 9365
GSR 9256
NCF2 9209
CAT 9137
CYBB 9000
PRDX6 8986
ERO1A 8853
PRDX5 8612
P4HB 8452
TXN 8414
TXNRD1 8303
TXNRD2 7556
NCF1 7433
PRDX1 7104
CYBA 6952
TXN2 4728
SOD2 4458
ATOX1 4439
PRDX2 3467
NUDT2 3089
CCS 1374
NOX5 1279
NOX4 1116
GPX3 857
ATP7A 647
GSTP1 197
CYCS -1282
GPX2 -3560
SOD1 -4927
GPX7 -9056


COPI-independent Golgi-to-ER retrograde traffic

133
set COPI-independent Golgi-to-ER retrograde traffic
setSize 33
pANOVA 2.42e-08
s.dist 0.561
p.adjustANOVA 5e-07



Top enriched genes

GeneID Gene Rank
PLA2G4A 9234
DCTN2 9158
GALNT2 8896
BICD2 8786
CAPZA2 8521
DCTN4 8385
RAB6A 8223
CAPZA1 8165
CAPZB 8057
RAB18 7893
ACTR10 7652
DYNC1I2 7629
DCTN6 7382
ACTR1A 7088
PAFAH1B2 7026
DYNC1LI1 6992
GALNT1 6518
RAB6B 6149
DCTN3 6080
DYNLL1 6049

Click HERE to show all gene set members

GeneID Gene Rank
PLA2G4A 9234
DCTN2 9158
GALNT2 8896
BICD2 8786
CAPZA2 8521
DCTN4 8385
RAB6A 8223
CAPZA1 8165
CAPZB 8057
RAB18 7893
ACTR10 7652
DYNC1I2 7629
DCTN6 7382
ACTR1A 7088
PAFAH1B2 7026
DYNC1LI1 6992
GALNT1 6518
RAB6B 6149
DCTN3 6080
DYNLL1 6049
RAB3GAP1 5800
PAFAH1B1 5534
DCTN1 5143
AGPAT3 4625
RAB3GAP2 4478
PAFAH1B3 4373
DYNC1LI2 4253
DYNC1I1 4211
DYNLL2 -4042
DCTN5 -4140
BICD1 -7322
DYNC1H1 -7822
PLA2G6 -12020


RHO GTPases Activate NADPH Oxidases

887
set RHO GTPases Activate NADPH Oxidases
setSize 21
pANOVA 9.46e-06
s.dist 0.558
p.adjustANOVA 7.68e-05



Top enriched genes

GeneID Gene Rank
S100A9 9562
S100A8 9560
NCF4 9365
MAPK14 9219
NCF2 9209
MAPK3 9078
PRKCD 9012
CYBB 9000
RAC1 8720
MAPK1 7520
NCF1 7433
PRKCB 7056
CYBA 6952
RAC2 5238
MAPK11 3955
PIK3C3 1626
PRKCA 1163
PIN1 -3272
PIK3R4 -4040
NOXA1 -5532

Click HERE to show all gene set members

GeneID Gene Rank
S100A9 9562
S100A8 9560
NCF4 9365
MAPK14 9219
NCF2 9209
MAPK3 9078
PRKCD 9012
CYBB 9000
RAC1 8720
MAPK1 7520
NCF1 7433
PRKCB 7056
CYBA 6952
RAC2 5238
MAPK11 3955
PIK3C3 1626
PRKCA 1163
PIN1 -3272
PIK3R4 -4040
NOXA1 -5532
PRKCZ -11508


PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

801
set PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
setSize 13
pANOVA 0.000533
s.dist 0.555
p.adjustANOVA 0.00241



Top enriched genes

GeneID Gene Rank
CRK 8941
RAC1 8720
RHOA 8218
DOCK1 7413
PXN 6332
ELMO1 6324
PTK6 5998
NRAS 5411
ELMO2 4507
KRAS 3760
RASA1 2134
HRAS -3335
ARHGAP35 -3408

Click HERE to show all gene set members

GeneID Gene Rank
CRK 8941
RAC1 8720
RHOA 8218
DOCK1 7413
PXN 6332
ELMO1 6324
PTK6 5998
NRAS 5411
ELMO2 4507
KRAS 3760
RASA1 2134
HRAS -3335
ARHGAP35 -3408


Platelet sensitization by LDL

833
set Platelet sensitization by LDL
setSize 16
pANOVA 0.000133
s.dist 0.552
p.adjustANOVA 0.000725



Top enriched genes

GeneID Gene Rank
PLA2G4A 9234
MAPK14 9219
FGR 8397
PPP2CA 8308
PPP2CB 7769
PECAM1 7743
PPP2R5B 6870
PTPN6 6176
PPP2R5A 5985
PTPN11 5383
PPP2R1A 4669
LRP8 4619
PPP2R5D 2440
PPP2R1B -246
PPP2R5E -627
PPP2R5C -11413

Click HERE to show all gene set members

GeneID Gene Rank
PLA2G4A 9234
MAPK14 9219
FGR 8397
PPP2CA 8308
PPP2CB 7769
PECAM1 7743
PPP2R5B 6870
PTPN6 6176
PPP2R5A 5985
PTPN11 5383
PPP2R1A 4669
LRP8 4619
PPP2R5D 2440
PPP2R1B -246
PPP2R5E -627
PPP2R5C -11413


Hyaluronan metabolism

504
set Hyaluronan metabolism
setSize 15
pANOVA 0.000223
s.dist 0.55
p.adjustANOVA 0.00113



Top enriched genes

GeneID Gene Rank
CHP1 9263
LYVE1 9187
HYAL2 9156
HEXB 8749
CD44 8314
SLC9A1 8016
GUSB 7454
STAB2 5599
HYAL3 5235
HYAL1 4297
HMMR 4051
ABCC5 2534
HEXA 1274
HAS3 -6214
CEMIP -7233

Click HERE to show all gene set members

GeneID Gene Rank
CHP1 9263
LYVE1 9187
HYAL2 9156
HEXB 8749
CD44 8314
SLC9A1 8016
GUSB 7454
STAB2 5599
HYAL3 5235
HYAL1 4297
HMMR 4051
ABCC5 2534
HEXA 1274
HAS3 -6214
CEMIP -7233


Golgi Cisternae Pericentriolar Stack Reorganization

468
set Golgi Cisternae Pericentriolar Stack Reorganization
setSize 14
pANOVA 0.000375
s.dist 0.549
p.adjustANOVA 0.00178



Top enriched genes

GeneID Gene Rank
MAPK3 9078
RAB1A 9075
RAB2A 8597
RAB1B 8407
MAPK1 7520
GORASP1 6670
GOLGA2 6217
USO1 4192
CCNB2 3836
BLZF1 3326
PLK1 3065
CDK1 1480
CCNB1 460
GORASP2 -7092

Click HERE to show all gene set members

GeneID Gene Rank
MAPK3 9078
RAB1A 9075
RAB2A 8597
RAB1B 8407
MAPK1 7520
GORASP1 6670
GOLGA2 6217
USO1 4192
CCNB2 3836
BLZF1 3326
PLK1 3065
CDK1 1480
CCNB1 460
GORASP2 -7092


Phosphorylation of CD3 and TCR zeta chains

821
set Phosphorylation of CD3 and TCR zeta chains
setSize 27
pANOVA 1.11e-06
s.dist -0.541
p.adjustANOVA 1.32e-05



Top enriched genes

GeneID Gene Rank
CD247 -12295
HLA-DPA1 -12271
HLA-DPB1 -12203
HLA-DRA -12007
TRBC1 -11859
HLA-DQA1 -11763
LCK -11492
CD3G -11409
CD3D -11094
CD3E -11042
TRAC -10981
TRBV12-3 -10279
TRAV19 -10023
TRBV7-9 -9564
HLA-DQB2 -9390
TRAV8-4 -9384
TRAV29DV5 -9334
HLA-DRB1 -8159
HLA-DQB1 -5703
CD4 -5320

Click HERE to show all gene set members

GeneID Gene Rank
CD247 -12295
HLA-DPA1 -12271
HLA-DPB1 -12203
HLA-DRA -12007
TRBC1 -11859
HLA-DQA1 -11763
LCK -11492
CD3G -11409
CD3D -11094
CD3E -11042
TRAC -10981
TRBV12-3 -10279
TRAV19 -10023
TRBV7-9 -9564
HLA-DQB2 -9390
TRAV8-4 -9384
TRAV29DV5 -9334
HLA-DRB1 -8159
HLA-DQB1 -5703
CD4 -5320
HLA-DRB5 -5140
HLA-DQA2 -4793
PTPN22 -1112
PTPRC 2253
PAG1 4088
CSK 5285
PTPRJ 7833


RHO GTPases Activate ROCKs

888
set RHO GTPases Activate ROCKs
setSize 18
pANOVA 7.25e-05
s.dist 0.54
p.adjustANOVA 0.000439



Top enriched genes

GeneID Gene Rank
MYL6 8687
PAK1 8252
CFL1 8242
RHOA 8218
LIMK2 8190
MYL9 7719
ROCK1 7445
PPP1CB 7093
MYH9 6772
ROCK2 6151
PPP1R12A 6131
MYL12B 5177
LIMK1 4741
PPP1R12B 1737
RHOB 1190
MYH10 663
MYH11 -3490
RHOC -11333

Click HERE to show all gene set members

GeneID Gene Rank
MYL6 8687
PAK1 8252
CFL1 8242
RHOA 8218
LIMK2 8190
MYL9 7719
ROCK1 7445
PPP1CB 7093
MYH9 6772
ROCK2 6151
PPP1R12A 6131
MYL12B 5177
LIMK1 4741
PPP1R12B 1737
RHOB 1190
MYH10 663
MYH11 -3490
RHOC -11333


Diseases associated with the TLR signaling cascade

289
set Diseases associated with the TLR signaling cascade
setSize 23
pANOVA 8.58e-06
s.dist 0.536
p.adjustANOVA 7.09e-05



Top enriched genes

GeneID Gene Rank
CD36 9486
TLR5 9254
CD14 9164
TLR2 9069
TLR1 9041
TLR4 8981
TLR6 8931
LY96 8871
MYD88 8091
CHUK 7959
BTK 7156
NFKBIA 6835
TICAM1 6380
NFKB1 6367
TIRAP 5700
IKBKG 5434
UNC93B1 4133
NFKB2 -865
RELA -1807
TLR10 -2899

Click HERE to show all gene set members

GeneID Gene Rank
CD36 9486
TLR5 9254
CD14 9164
TLR2 9069
TLR1 9041
TLR4 8981
TLR6 8931
LY96 8871
MYD88 8091
CHUK 7959
BTK 7156
NFKBIA 6835
TICAM1 6380
NFKB1 6367
TIRAP 5700
IKBKG 5434
UNC93B1 4133
NFKB2 -865
RELA -1807
TLR10 -2899
IKBKB -5290
TRAF3 -5296
TLR3 -11538


Diseases of Immune System

291
set Diseases of Immune System
setSize 23
pANOVA 8.58e-06
s.dist 0.536
p.adjustANOVA 7.09e-05



Top enriched genes

GeneID Gene Rank
CD36 9486
TLR5 9254
CD14 9164
TLR2 9069
TLR1 9041
TLR4 8981
TLR6 8931
LY96 8871
MYD88 8091
CHUK 7959
BTK 7156
NFKBIA 6835
TICAM1 6380
NFKB1 6367
TIRAP 5700
IKBKG 5434
UNC93B1 4133
NFKB2 -865
RELA -1807
TLR10 -2899

Click HERE to show all gene set members

GeneID Gene Rank
CD36 9486
TLR5 9254
CD14 9164
TLR2 9069
TLR1 9041
TLR4 8981
TLR6 8931
LY96 8871
MYD88 8091
CHUK 7959
BTK 7156
NFKBIA 6835
TICAM1 6380
NFKB1 6367
TIRAP 5700
IKBKG 5434
UNC93B1 4133
NFKB2 -865
RELA -1807
TLR10 -2899
IKBKB -5290
TRAF3 -5296
TLR3 -11538


IRAK1 recruits IKK complex

509
set IRAK1 recruits IKK complex
setSize 10
pANOVA 0.00375
s.dist 0.529
p.adjustANOVA 0.0121



Top enriched genes

GeneID Gene Rank
PELI2 8166
CHUK 7959
PELI3 7736
PELI1 6596
IRAK1 6159
UBE2V1 5681
IKBKG 5434
UBE2N 1951
TRAF6 -241
IKBKB -5290

Click HERE to show all gene set members

GeneID Gene Rank
PELI2 8166
CHUK 7959
PELI3 7736
PELI1 6596
IRAK1 6159
UBE2V1 5681
IKBKG 5434
UBE2N 1951
TRAF6 -241
IKBKB -5290


IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

510
set IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
setSize 10
pANOVA 0.00375
s.dist 0.529
p.adjustANOVA 0.0121



Top enriched genes

GeneID Gene Rank
PELI2 8166
CHUK 7959
PELI3 7736
PELI1 6596
IRAK1 6159
UBE2V1 5681
IKBKG 5434
UBE2N 1951
TRAF6 -241
IKBKB -5290

Click HERE to show all gene set members

GeneID Gene Rank
PELI2 8166
CHUK 7959
PELI3 7736
PELI1 6596
IRAK1 6159
UBE2V1 5681
IKBKG 5434
UBE2N 1951
TRAF6 -241
IKBKB -5290


DNA strand elongation

247
set DNA strand elongation
setSize 32
pANOVA 2.48e-07
s.dist -0.527
p.adjustANOVA 3.94e-06



Top enriched genes

GeneID Gene Rank
MCM3 -12163
POLA1 -12121
MCM7 -12004
RPA1 -11962
RFC5 -11754
POLA2 -11639
MCM8 -10989
FEN1 -10740
GINS3 -10524
RFC3 -10515
RFC4 -10511
LIG1 -10471
GINS4 -10394
PRIM1 -10176
MCM6 -9941
POLD2 -9925
RPA3 -9003
MCM4 -8819
RFC1 -7529
MCM5 -7430

Click HERE to show all gene set members

GeneID Gene Rank
MCM3 -12163
POLA1 -12121
MCM7 -12004
RPA1 -11962
RFC5 -11754
POLA2 -11639
MCM8 -10989
FEN1 -10740
GINS3 -10524
RFC3 -10515
RFC4 -10511
LIG1 -10471
GINS4 -10394
PRIM1 -10176
MCM6 -9941
POLD2 -9925
RPA3 -9003
MCM4 -8819
RFC1 -7529
MCM5 -7430
MCM2 -7316
RPA2 -6397
PCNA -6038
PRIM2 -5619
GINS2 -4841
GINS1 -4435
DNA2 -2882
CDC45 -2683
POLD1 133
RFC2 5040
POLD4 6429
POLD3 8712


Budding and maturation of HIV virion

117
set Budding and maturation of HIV virion
setSize 26
pANOVA 3.43e-06
s.dist 0.526
p.adjustANOVA 3.42e-05



Top enriched genes

GeneID Gene Rank
CHMP2A 8863
CHMP4B 8830
UBAP1 8779
CHMP3 8339
VPS37C 7973
NEDD4L 7972
TSG101 7856
MVB12A 7425
UBB 6737
PDCD6IP 6585
VPS37A 6560
VTA1 6232
CHMP2B 5713
CHMP6 5590
VPS4B 5279
MVB12B 5251
CHMP5 4954
UBC 4421
VPS28 4247
VPS37B 3933

Click HERE to show all gene set members

GeneID Gene Rank
CHMP2A 8863
CHMP4B 8830
UBAP1 8779
CHMP3 8339
VPS37C 7973
NEDD4L 7972
TSG101 7856
MVB12A 7425
UBB 6737
PDCD6IP 6585
VPS37A 6560
VTA1 6232
CHMP2B 5713
CHMP6 5590
VPS4B 5279
MVB12B 5251
CHMP5 4954
UBC 4421
VPS28 4247
VPS37B 3933
CHMP4A 2480
UBA52 1071
VPS4A 776
RPS27A -6894
PPIA -6900
CHMP7 -8325


Negative regulation of MET activity

723
set Negative regulation of MET activity
setSize 18
pANOVA 0.000112
s.dist 0.526
p.adjustANOVA 0.000634



Top enriched genes

GeneID Gene Rank
GRB2 9320
HGF 8856
PTPRJ 7833
SH3GL1 7733
PTPN2 7634
CBL 7599
UBB 6737
USP8 6383
SH3KBP1 6227
STAM2 6183
PTPN1 5797
HGS 4570
UBC 4421
EPS15 4189
STAM 1299
UBA52 1071
RPS27A -6894
LRIG1 -10216

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 9320
HGF 8856
PTPRJ 7833
SH3GL1 7733
PTPN2 7634
CBL 7599
UBB 6737
USP8 6383
SH3KBP1 6227
STAM2 6183
PTPN1 5797
HGS 4570
UBC 4421
EPS15 4189
STAM 1299
UBA52 1071
RPS27A -6894
LRIG1 -10216


MET activates RAP1 and RAC1

620
set MET activates RAP1 and RAC1
setSize 10
pANOVA 0.00401
s.dist 0.525
p.adjustANOVA 0.0128



Top enriched genes

GeneID Gene Rank
GRB2 9320
CRK 8941
HGF 8856
RAC1 8720
RAP1A 7319
GAB1 5723
CRKL 3986
RAP1B 3331
DOCK7 -2432
RAPGEF1 -10033

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 9320
CRK 8941
HGF 8856
RAC1 8720
RAP1A 7319
GAB1 5723
CRKL 3986
RAP1B 3331
DOCK7 -2432
RAPGEF1 -10033


InlB-mediated entry of Listeria monocytogenes into host cell

535
set InlB-mediated entry of Listeria monocytogenes into host cell
setSize 12
pANOVA 0.00163
s.dist 0.525
p.adjustANOVA 0.00605



Top enriched genes

GeneID Gene Rank
GRB2 9320
SH3GL1 7733
CBL 7599
UBB 6737
SH3KBP1 6227
STAM2 6183
HGS 4570
UBC 4421
EPS15 4189
STAM 1299
UBA52 1071
RPS27A -6894

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 9320
SH3GL1 7733
CBL 7599
UBB 6737
SH3KBP1 6227
STAM2 6183
HGS 4570
UBC 4421
EPS15 4189
STAM 1299
UBA52 1071
RPS27A -6894


DNA methylation

246
set DNA methylation
setSize 20
pANOVA 5.29e-05
s.dist 0.522
p.adjustANOVA 0.000342



Top enriched genes

GeneID Gene Rank
H2AJ 9418.0
H2BC21 9368.0
H2BC12 9178.0
H3-3A 8754.0
H2BC5 8163.0
H2BC11 8076.0
H2AC6 8070.0
H2BC4 7549.0
H2BC17 7502.0
H3C15 6780.5
H2AZ1 6126.0
H2BC9 5461.0
H2BC15 5458.0
H2AC20 5039.0
DNMT3B 4348.0
UHRF1 177.0
H2AZ2 -1266.0
DNMT3A -2812.0
H2BU1 -6519.0
DNMT1 -12192.0

Click HERE to show all gene set members

GeneID Gene Rank
H2AJ 9418.0
H2BC21 9368.0
H2BC12 9178.0
H3-3A 8754.0
H2BC5 8163.0
H2BC11 8076.0
H2AC6 8070.0
H2BC4 7549.0
H2BC17 7502.0
H3C15 6780.5
H2AZ1 6126.0
H2BC9 5461.0
H2BC15 5458.0
H2AC20 5039.0
DNMT3B 4348.0
UHRF1 177.0
H2AZ2 -1266.0
DNMT3A -2812.0
H2BU1 -6519.0
DNMT1 -12192.0


NOTCH4 Activation and Transmission of Signal to the Nucleus

707
set NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize 10
pANOVA 0.00432
s.dist 0.521
p.adjustANOVA 0.0134



Top enriched genes

GeneID Gene Rank
NCSTN 9139
ADAM10 8705
JAG1 8661
PSEN1 7843
APH1B 6248
PSENEN 5833
YWHAZ 5687
APH1A 4198
NOTCH4 -5200
PSEN2 -7844

Click HERE to show all gene set members

GeneID Gene Rank
NCSTN 9139
ADAM10 8705
JAG1 8661
PSEN1 7843
APH1B 6248
PSENEN 5833
YWHAZ 5687
APH1A 4198
NOTCH4 -5200
PSEN2 -7844


Endosomal Sorting Complex Required For Transport (ESCRT)

340
set Endosomal Sorting Complex Required For Transport (ESCRT)
setSize 29
pANOVA 1.26e-06
s.dist 0.52
p.adjustANOVA 1.48e-05



Top enriched genes

GeneID Gene Rank
CHMP2A 8863
CHMP4B 8830
UBAP1 8779
CHMP3 8339
VPS37C 7973
TSG101 7856
VPS25 7696
MVB12A 7425
UBB 6737
VPS37A 6560
VTA1 6232
STAM2 6183
SNF8 5990
CHMP2B 5713
CHMP6 5590
VPS4B 5279
MVB12B 5251
CHMP5 4954
HGS 4570
UBC 4421

Click HERE to show all gene set members

GeneID Gene Rank
CHMP2A 8863
CHMP4B 8830
UBAP1 8779
CHMP3 8339
VPS37C 7973
TSG101 7856
VPS25 7696
MVB12A 7425
UBB 6737
VPS37A 6560
VTA1 6232
STAM2 6183
SNF8 5990
CHMP2B 5713
CHMP6 5590
VPS4B 5279
MVB12B 5251
CHMP5 4954
HGS 4570
UBC 4421
VPS28 4247
VPS37B 3933
CHMP4A 2480
STAM 1299
UBA52 1071
VPS4A 776
RPS27A -6894
VPS36 -6942
CHMP7 -8325


Cargo concentration in the ER

147
set Cargo concentration in the ER
setSize 30
pANOVA 8.85e-07
s.dist 0.518
p.adjustANOVA 1.12e-05



Top enriched genes

GeneID Gene Rank
F5 9524
SERPINA1 9179
TGFA 9031
CTSZ 9001
SEC24D 8130
CNIH1 7832
SEC24A 7716
SEC23A 7416
STX5 7186
LMAN2 7178
MCFD2 7136
LMAN2L 7003
F8 6996
SAR1B 6562
PREB 6450
COL7A1 6375
TMED2 6098
CD59 5964
SEC22B 5939
MIA2 5618

Click HERE to show all gene set members

GeneID Gene Rank
F5 9524
SERPINA1 9179
TGFA 9031
CTSZ 9001
SEC24D 8130
CNIH1 7832
SEC24A 7716
SEC23A 7416
STX5 7186
LMAN2 7178
MCFD2 7136
LMAN2L 7003
F8 6996
SAR1B 6562
PREB 6450
COL7A1 6375
TMED2 6098
CD59 5964
SEC22B 5939
MIA2 5618
AREG 5494
SEC24B 3655
CTSC 2547
CNIH2 727
TMED10 328
GOSR2 -1504
SEC24C -2615
MIA3 -6330
CNIH3 -9196
LMAN1 -10699


MAP2K and MAPK activation

611
set MAP2K and MAPK activation
setSize 34
pANOVA 1.76e-07
s.dist 0.517
p.adjustANOVA 2.82e-06



Top enriched genes

GeneID Gene Rank
MAPK3 9078
MAP2K1 8960
ITGA2B 8942
APBB1IP 8849
MARK3 8774
TLN1 8554
ARRB2 8517
ITGB3 8367
FN1 8294
IQGAP1 8189
RAF1 7991
LAMTOR2 7704
LAMTOR3 7692
MAPK1 7520
VCL 7380
RAP1A 7319
MAP2K2 6906
VWF 6607
YWHAB 6398
NRAS 5411

Click HERE to show all gene set members

GeneID Gene Rank
MAPK3 9078
MAP2K1 8960
ITGA2B 8942
APBB1IP 8849
MARK3 8774
TLN1 8554
ARRB2 8517
ITGB3 8367
FN1 8294
IQGAP1 8189
RAF1 7991
LAMTOR2 7704
LAMTOR3 7692
MAPK1 7520
VCL 7380
RAP1A 7319
MAP2K2 6906
VWF 6607
YWHAB 6398
NRAS 5411
CSK 5285
KSR1 4113
WDR83 3802
KRAS 3760
RAP1B 3331
ARAF 2680
ARRB1 2098
BRAF 1314
HRAS -3335
KSR2 -3364
CNKSR2 -4481
CNKSR1 -6858
SRC -9011
PEBP1 -11270


Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

278
set Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
setSize 21
pANOVA 4.48e-05
s.dist 0.514
p.adjustANOVA 0.000294



Top enriched genes

GeneID Gene Rank
LMNB1 9391
APP 9123
YWHAE 9009
FOXO3 8729
CDK5 8663
CAPN1 8613
CAST 8045
CAPNS1 7603
BCL2L11 7326
PRDX1 7104
GOLGA2 6217
CDC25C 5024
SOD2 4458
JUN 3964
LMNA 3863
PRDX2 3467
CDC25A 2948
CAPN2 1058
CDK5R1 -1166
CDC25B -11871

Click HERE to show all gene set members

GeneID Gene Rank
LMNB1 9391
APP 9123
YWHAE 9009
FOXO3 8729
CDK5 8663
CAPN1 8613
CAST 8045
CAPNS1 7603
BCL2L11 7326
PRDX1 7104
GOLGA2 6217
CDC25C 5024
SOD2 4458
JUN 3964
LMNA 3863
PRDX2 3467
CDC25A 2948
CAPN2 1058
CDK5R1 -1166
CDC25B -11871
FASLG -12319


Neurodegenerative Diseases

732
set Neurodegenerative Diseases
setSize 21
pANOVA 4.48e-05
s.dist 0.514
p.adjustANOVA 0.000294



Top enriched genes

GeneID Gene Rank
LMNB1 9391
APP 9123
YWHAE 9009
FOXO3 8729
CDK5 8663
CAPN1 8613
CAST 8045
CAPNS1 7603
BCL2L11 7326
PRDX1 7104
GOLGA2 6217
CDC25C 5024
SOD2 4458
JUN 3964
LMNA 3863
PRDX2 3467
CDC25A 2948
CAPN2 1058
CDK5R1 -1166
CDC25B -11871

Click HERE to show all gene set members

GeneID Gene Rank
LMNB1 9391
APP 9123
YWHAE 9009
FOXO3 8729
CDK5 8663
CAPN1 8613
CAST 8045
CAPNS1 7603
BCL2L11 7326
PRDX1 7104
GOLGA2 6217
CDC25C 5024
SOD2 4458
JUN 3964
LMNA 3863
PRDX2 3467
CDC25A 2948
CAPN2 1058
CDK5R1 -1166
CDC25B -11871
FASLG -12319


VLDLR internalisation and degradation

1310
set VLDLR internalisation and degradation
setSize 12
pANOVA 0.00222
s.dist 0.51
p.adjustANOVA 0.00788



Top enriched genes

GeneID Gene Rank
PCSK9 9229
CLTC 9056
AP2M1 8673
CLTA 8402
AP2S1 8080
NR1H2 7512
AP2A2 7360
AP2A1 6628
AP2B1 -2748
NR1H3 -3418
MYLIP -4005
VLDLR -4336

Click HERE to show all gene set members

GeneID Gene Rank
PCSK9 9229
CLTC 9056
AP2M1 8673
CLTA 8402
AP2S1 8080
NR1H2 7512
AP2A2 7360
AP2A1 6628
AP2B1 -2748
NR1H3 -3418
MYLIP -4005
VLDLR -4336


Transferrin endocytosis and recycling

1267
set Transferrin endocytosis and recycling
setSize 26
pANOVA 7.09e-06
s.dist 0.509
p.adjustANOVA 6.16e-05



Top enriched genes

GeneID Gene Rank
ATP6V0A1 9483
ATP6V1A 9301
ATP6V0D1 9298
ATP6V1D 9118
ATP6V0C 9113
ATP6V1B2 9005
HFE 8894
ATP6V0B 8701
ATP6V0E1 8662
ATP6V1C1 8628
ATP6V1H 8119
ATP6V1E1 8107
ATP6AP1 8035
MCOLN1 7715
TCIRG1 7266
STEAP3 6076
ATP6V1F 5949
ATP6V1E2 5776
ATP6V1G1 3989
TFRC 1578

Click HERE to show all gene set members

GeneID Gene Rank
ATP6V0A1 9483
ATP6V1A 9301
ATP6V0D1 9298
ATP6V1D 9118
ATP6V0C 9113
ATP6V1B2 9005
HFE 8894
ATP6V0B 8701
ATP6V0E1 8662
ATP6V1C1 8628
ATP6V1H 8119
ATP6V1E1 8107
ATP6AP1 8035
MCOLN1 7715
TCIRG1 7266
STEAP3 6076
ATP6V1F 5949
ATP6V1E2 5776
ATP6V1G1 3989
TFRC 1578
TF 1172
ATP6V1C2 -2222
ATP6V1G2 -9275
TFR2 -9972
ATP6V0E2 -11475
ATP6V0A2 -12193


Gap junction trafficking

437
set Gap junction trafficking
setSize 14
pANOVA 0.0012
s.dist 0.5
p.adjustANOVA 0.00476



Top enriched genes

GeneID Gene Rank
CLTC 9056
CLTCL1 8939
AP2M1 8673
CLTA 8402
DAB2 8259
GJD3 8052
CLTB 6195
DNM2 6163
GJB6 4826
DNM1 3526
GJC2 662
GJC1 538
GJA3 -4488
MYO6 -11522

Click HERE to show all gene set members

GeneID Gene Rank
CLTC 9056
CLTCL1 8939
AP2M1 8673
CLTA 8402
DAB2 8259
GJD3 8052
CLTB 6195
DNM2 6163
GJB6 4826
DNM1 3526
GJC2 662
GJC1 538
GJA3 -4488
MYO6 -11522


Platelet Adhesion to exposed collagen

827
set Platelet Adhesion to exposed collagen
setSize 13
pANOVA 0.00183
s.dist 0.499
p.adjustANOVA 0.00675



Top enriched genes

GeneID Gene Rank
ITGA1 8818
FCER1G 8143
LYN 7728
GP1BB 7606
GP9 7589
GP6 6890
VWF 6607
GP1BA 6320
ITGA2 4159
GP5 1281
ITGB1 -50
ITGA10 -226
FYN -11758

Click HERE to show all gene set members

GeneID Gene Rank
ITGA1 8818
FCER1G 8143
LYN 7728
GP1BB 7606
GP9 7589
GP6 6890
VWF 6607
GP1BA 6320
ITGA2 4159
GP5 1281
ITGB1 -50
ITGA10 -226
FYN -11758


EPHB-mediated forward signaling

325
set EPHB-mediated forward signaling
setSize 32
pANOVA 1.02e-06
s.dist 0.499
p.adjustANOVA 1.24e-05



Top enriched genes

GeneID Gene Rank
ARPC1B 9303
ITSN1 9186
ACTB 9060
ARPC1A 8923
RAC1 8720
ACTG1 8671
ARPC5 8653
ARPC3 8309
PAK1 8252
CFL1 8242
RHOA 8218
LIMK2 8190
ACTR3 7888
ACTR2 7827
LYN 7728
ARPC4 7605
CDC42 7539
ARPC2 7449
ROCK1 7445
ROCK2 6151

Click HERE to show all gene set members

GeneID Gene Rank
ARPC1B 9303
ITSN1 9186
ACTB 9060
ARPC1A 8923
RAC1 8720
ACTG1 8671
ARPC5 8653
ARPC3 8309
PAK1 8252
CFL1 8242
RHOA 8218
LIMK2 8190
ACTR3 7888
ACTR2 7827
LYN 7728
ARPC4 7605
CDC42 7539
ARPC2 7449
ROCK1 7445
ROCK2 6151
SDC2 5257
LIMK1 4741
PTK2 4506
RASA1 2134
TIAM1 701
WASL 283
HRAS -3335
KALRN -3725
SRC -9011
ARHGEF28 -10479
FYN -11758
YES1 -12143


Signaling by high-kinase activity BRAF mutants

1142
set Signaling by high-kinase activity BRAF mutants
setSize 31
pANOVA 1.54e-06
s.dist 0.499
p.adjustANOVA 1.77e-05



Top enriched genes

GeneID Gene Rank
MAPK3 9078
MAP2K1 8960
ITGA2B 8942
APBB1IP 8849
MARK3 8774
TLN1 8554
ARRB2 8517
ITGB3 8367
FN1 8294
IQGAP1 8189
RAF1 7991
MAPK1 7520
VCL 7380
RAP1A 7319
MAP2K2 6906
VWF 6607
YWHAB 6398
NRAS 5411
CSK 5285
KSR1 4113

Click HERE to show all gene set members

GeneID Gene Rank
MAPK3 9078
MAP2K1 8960
ITGA2B 8942
APBB1IP 8849
MARK3 8774
TLN1 8554
ARRB2 8517
ITGB3 8367
FN1 8294
IQGAP1 8189
RAF1 7991
MAPK1 7520
VCL 7380
RAP1A 7319
MAP2K2 6906
VWF 6607
YWHAB 6398
NRAS 5411
CSK 5285
KSR1 4113
KRAS 3760
RAP1B 3331
ARAF 2680
ARRB1 2098
BRAF 1314
HRAS -3335
KSR2 -3364
CNKSR2 -4481
CNKSR1 -6858
SRC -9011
PEBP1 -11270


Smooth Muscle Contraction

1149
set Smooth Muscle Contraction
setSize 31
pANOVA 1.95e-06
s.dist 0.494
p.adjustANOVA 2.15e-05



Top enriched genes

GeneID Gene Rank
DYSF 9517
TPM4 9246
ITGA1 8818
MYL6 8687
TLN1 8554
ANXA2 8424
MYL6B 8320
CALD1 8280
PAK1 8252
PAK2 8226
TPM1 8142
TPM3 8006
MYL9 7719
ANXA1 7530
VCL 7380
ITGB5 7004
MYL12A 6981
MYLK 6690
PXN 6332
MYL12B 5177

Click HERE to show all gene set members

GeneID Gene Rank
DYSF 9517
TPM4 9246
ITGA1 8818
MYL6 8687
TLN1 8554
ANXA2 8424
MYL6B 8320
CALD1 8280
PAK1 8252
PAK2 8226
TPM1 8142
TPM3 8006
MYL9 7719
ANXA1 7530
VCL 7380
ITGB5 7004
MYL12A 6981
MYLK 6690
PXN 6332
MYL12B 5177
MYL5 3256
TRIM72 1996
SORBS1 1627
ANXA6 249
ACTA2 -430
CALM1 -2048
MYH11 -3490
GUCY1B2 -5105
MYLPF -8850
TPM2 -8911
SORBS3 -10935


Pentose phosphate pathway

807
set Pentose phosphate pathway
setSize 13
pANOVA 0.00232
s.dist 0.488
p.adjustANOVA 0.00817



Top enriched genes

GeneID Gene Rank
PGD 9530
TALDO1 9505
PGM2 9410
TKT 9382
G6PD 9045
DERA 8442
PGLS 6161
PRPS2 3597
RPE 2661
RPIA 1455
SHPK -2583
RBKS -3109
PRPS1 -11989

Click HERE to show all gene set members

GeneID Gene Rank
PGD 9530
TALDO1 9505
PGM2 9410
TKT 9382
G6PD 9045
DERA 8442
PGLS 6161
PRPS2 3597
RPE 2661
RPIA 1455
SHPK -2583
RBKS -3109
PRPS1 -11989


Activation of the pre-replicative complex

51
set Activation of the pre-replicative complex
setSize 32
pANOVA 1.82e-06
s.dist -0.487
p.adjustANOVA 2.02e-05



Top enriched genes

GeneID Gene Rank
MCM3 -12163
POLA1 -12121
MCM7 -12004
RPA1 -11962
POLE3 -11643
POLA2 -11639
DBF4 -11057
MCM8 -10989
ORC3 -10805
PRIM1 -10176
POLE2 -10111
MCM6 -9941
ORC2 -9875
ORC5 -9463
RPA3 -9003
MCM4 -8819
CDC7 -7896
POLE -7577
MCM5 -7430
MCM2 -7316

Click HERE to show all gene set members

GeneID Gene Rank
MCM3 -12163
POLA1 -12121
MCM7 -12004
RPA1 -11962
POLE3 -11643
POLA2 -11639
DBF4 -11057
MCM8 -10989
ORC3 -10805
PRIM1 -10176
POLE2 -10111
MCM6 -9941
ORC2 -9875
ORC5 -9463
RPA3 -9003
MCM4 -8819
CDC7 -7896
POLE -7577
MCM5 -7430
MCM2 -7316
RPA2 -6397
PRIM2 -5619
CDK2 -5018
CDC45 -2683
ORC1 -2472
ORC4 -2046
CDT1 -193
MCM10 781
GMNN 1437
ORC6 1507
CDC6 2399
POLE4 5612


Platelet Aggregation (Plug Formation)

828
set Platelet Aggregation (Plug Formation)
setSize 28
pANOVA 8.14e-06
s.dist 0.487
p.adjustANOVA 6.85e-05



Top enriched genes

GeneID Gene Rank
GRB2 9320
SYK 9087
ITGA2B 8942
CRK 8941
APBB1IP 8849
TLN1 8554
ITGB3 8367
FN1 8294
GP1BB 7606
GP9 7589
RAP1A 7319
VWF 6607
GP1BA 6320
PDPK1 6209
PTPN1 5797
CSK 5285
PTK2 4506
SHC1 4173
AKT1 3656
RAP1B 3331

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 9320
SYK 9087
ITGA2B 8942
CRK 8941
APBB1IP 8849
TLN1 8554
ITGB3 8367
FN1 8294
GP1BB 7606
GP9 7589
RAP1A 7319
VWF 6607
GP1BA 6320
PDPK1 6209
PTPN1 5797
CSK 5285
PTK2 4506
SHC1 4173
AKT1 3656
RAP1B 3331
MPL 2709
ADRA2A 2476
GP5 1281
RAPGEF3 25
SOS1 -5714
RASGRP2 -8137
SRC -9011
RASGRP1 -11817


RHO GTPases activate PAKs

893
set RHO GTPases activate PAKs
setSize 20
pANOVA 0.000179
s.dist 0.484
p.adjustANOVA 0.000933



Top enriched genes

GeneID Gene Rank
RAC1 8720
MYL6 8687
PAK1 8252
PAK2 8226
MYL9 7719
CDC42 7539
PPP1CB 7093
MYH9 6772
MYLK 6690
PPP1R12A 6131
CTTN 5999
MYL12B 5177
LIMK1 4741
PPP1R12B 1737
MYH10 663
FLNA 547
CALM1 -2048
MYH11 -3490
PAK3 -4194
NF2 -6614

Click HERE to show all gene set members

GeneID Gene Rank
RAC1 8720
MYL6 8687
PAK1 8252
PAK2 8226
MYL9 7719
CDC42 7539
PPP1CB 7093
MYH9 6772
MYLK 6690
PPP1R12A 6131
CTTN 5999
MYL12B 5177
LIMK1 4741
PPP1R12B 1737
MYH10 663
FLNA 547
CALM1 -2048
MYH11 -3490
PAK3 -4194
NF2 -6614


RHO GTPases activate PKNs

894
set RHO GTPases activate PKNs
setSize 48
pANOVA 6.59e-09
s.dist 0.484
p.adjustANOVA 1.47e-07



Top enriched genes

GeneID Gene Rank
H2AJ 9418.0
H2BC21 9368.0
YWHAG 9310.0
H2BC12 9178.0
YWHAE 9009.0
H3-3A 8754.0
RAC1 8720.0
MYL6 8687.0
YWHAH 8621.0
PAK1 8252.0
RHOA 8218.0
H2BC5 8163.0
H2BC11 8076.0
H2AC6 8070.0
MYL9 7719.0
H2BC4 7549.0
H2BC17 7502.0
PPP1CB 7093.0
PPP1R14A 7009.0
H3C15 6780.5

Click HERE to show all gene set members

GeneID Gene Rank
H2AJ 9418.0
H2BC21 9368.0
YWHAG 9310.0
H2BC12 9178.0
YWHAE 9009.0
H3-3A 8754.0
RAC1 8720.0
MYL6 8687.0
YWHAH 8621.0
PAK1 8252.0
RHOA 8218.0
H2BC5 8163.0
H2BC11 8076.0
H2AC6 8070.0
MYL9 7719.0
H2BC4 7549.0
H2BC17 7502.0
PPP1CB 7093.0
PPP1R14A 7009.0
H3C15 6780.5
MYH9 6772.0
YWHAB 6398.0
PDPK1 6209.0
PPP1R12A 6131.0
H2AZ1 6126.0
YWHAZ 5687.0
H2BC9 5461.0
H2BC15 5458.0
MYL12B 5177.0
H2AC20 5039.0
CDC25C 5024.0
AR 4913.0
KLK2 3082.0
PPP1R12B 1737.0
SFN 1557.0
RHOB 1190.0
NCOA2 1109.0
MYH10 663.0
PKN2 151.0
H2AZ2 -1266.0
PKN1 -1986.0
MYH11 -3490.0
PKN3 -3714.0
H2BU1 -6519.0
YWHAQ -7471.0
KDM1A -9476.0
KDM4C -10513.0
RHOC -11333.0


Amyloid fiber formation

70
set Amyloid fiber formation
setSize 51
pANOVA 2.47e-09
s.dist 0.483
p.adjustANOVA 5.83e-08



Top enriched genes

GeneID Gene Rank
SNCA 9421.0
H2BC21 9368.0
H2BC12 9178.0
FURIN 9162.0
NCSTN 9139.0
APP 9123.0
GSN 8805.0
H3-3A 8754.0
ADAM10 8705.0
SIAH2 8657.0
TGFBI 8304.0
H2BC5 8163.0
H2BC11 8076.0
H2AC6 8070.0
H2BC4 7549.0
H2BC17 7502.0
LYZ 7202.0
TSPAN14 7007.0
H3C15 6780.5
UBB 6737.0

Click HERE to show all gene set members

GeneID Gene Rank
SNCA 9421.0
H2BC21 9368.0
H2BC12 9178.0
FURIN 9162.0
NCSTN 9139.0
APP 9123.0
GSN 8805.0
H3-3A 8754.0
ADAM10 8705.0
SIAH2 8657.0
TGFBI 8304.0
H2BC5 8163.0
H2BC11 8076.0
H2AC6 8070.0
H2BC4 7549.0
H2BC17 7502.0
LYZ 7202.0
TSPAN14 7007.0
H3C15 6780.5
UBB 6737.0
SORL1 6654.0
TSPAN33 6301.0
APH1B 6248.0
LTF 6182.0
H2AZ1 6126.0
ITM2B 6042.0
PSENEN 5833.0
USP9X 5542.0
H2BC9 5461.0
H2BC15 5458.0
H2AC20 5039.0
UBC 4421.0
APH1A 4198.0
GGA3 3846.0
MFGE8 3718.0
BACE1 3627.0
GGA1 2327.0
CST3 2157.0
UBA52 1071.0
TSPAN5 1049.0
NPPA -569.0
TSPAN15 -1940.0
CALB1 -2900.0
SIAH1 -3004.0
NAT8B -3928.0
H2BU1 -6519.0
GGA2 -6523.0
RPS27A -6894.0
B2M -7019.0
HSPG2 -7708.0
UBE2L6 -11415.0


Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)

266
set Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
setSize 12
pANOVA 0.0041
s.dist 0.478
p.adjustANOVA 0.013



Top enriched genes

GeneID Gene Rank
F12 9535
TPST1 9377
GP1BB 7606
GP9 7589
F8 6996
VWF 6607
GP1BA 6320
TPST2 5872
GGCX 5306
GP5 1281
KLKB1 -8735
SERPING1 -11444

Click HERE to show all gene set members

GeneID Gene Rank
F12 9535
TPST1 9377
GP1BB 7606
GP9 7589
F8 6996
VWF 6607
GP1BA 6320
TPST2 5872
GGCX 5306
GP5 1281
KLKB1 -8735
SERPING1 -11444


Diseases of hemostasis

294
set Diseases of hemostasis
setSize 12
pANOVA 0.0041
s.dist 0.478
p.adjustANOVA 0.013



Top enriched genes

GeneID Gene Rank
F12 9535
TPST1 9377
GP1BB 7606
GP9 7589
F8 6996
VWF 6607
GP1BA 6320
TPST2 5872
GGCX 5306
GP5 1281
KLKB1 -8735
SERPING1 -11444

Click HERE to show all gene set members

GeneID Gene Rank
F12 9535
TPST1 9377
GP1BB 7606
GP9 7589
F8 6996
VWF 6607
GP1BA 6320
TPST2 5872
GGCX 5306
GP5 1281
KLKB1 -8735
SERPING1 -11444


Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

32
set Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
setSize 22
pANOVA 0.00011
s.dist 0.476
p.adjustANOVA 0.000624



Top enriched genes

GeneID Gene Rank
H2AJ 9418.0
H2BC21 9368.0
H2BC12 9178.0
H3-3A 8754.0
H2BC5 8163.0
H2BC11 8076.0
H2AC6 8070.0
H2BC4 7549.0
H2BC17 7502.0
H3C15 6780.5
H2AZ1 6126.0
H2BC9 5461.0
H2BC15 5458.0
H2AC20 5039.0
AR 4913.0
KLK2 3082.0
NCOA2 1109.0
H2AZ2 -1266.0
PKN1 -1986.0
H2BU1 -6519.0

Click HERE to show all gene set members

GeneID Gene Rank
H2AJ 9418.0
H2BC21 9368.0
H2BC12 9178.0
H3-3A 8754.0
H2BC5 8163.0
H2BC11 8076.0
H2AC6 8070.0
H2BC4 7549.0
H2BC17 7502.0
H3C15 6780.5
H2AZ1 6126.0
H2BC9 5461.0
H2BC15 5458.0
H2AC20 5039.0
AR 4913.0
KLK2 3082.0
NCOA2 1109.0
H2AZ2 -1266.0
PKN1 -1986.0
H2BU1 -6519.0
KDM1A -9476.0
KDM4C -10513.0


SHC1 events in EGFR signaling

1031
set SHC1 events in EGFR signaling
setSize 12
pANOVA 0.00443
s.dist 0.474
p.adjustANOVA 0.0137



Top enriched genes

GeneID Gene Rank
GRB2 9320
TGFA 9031
EGF 8267
AREG 5494
NRAS 5411
HBEGF 4878
SHC1 4173
KRAS 3760
EPGN 2579
EREG 1906
HRAS -3335
SOS1 -5714

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 9320
TGFA 9031
EGF 8267
AREG 5494
NRAS 5411
HBEGF 4878
SHC1 4173
KRAS 3760
EPGN 2579
EREG 1906
HRAS -3335
SOS1 -5714


Trafficking of GluR2-containing AMPA receptors

1248
set Trafficking of GluR2-containing AMPA receptors
setSize 12
pANOVA 0.00459
s.dist 0.472
p.adjustANOVA 0.0141



Top enriched genes

GeneID Gene Rank
NSF 8815
AP2M1 8673
AP2S1 8080
TSPAN7 7393
AP2A2 7360
PRKCB 7056
AP2A1 6628
PICK1 3721
PRKCA 1163
GRIA4 -101
AP2B1 -2748
GRIP1 -10516

Click HERE to show all gene set members

GeneID Gene Rank
NSF 8815
AP2M1 8673
AP2S1 8080
TSPAN7 7393
AP2A2 7360
PRKCB 7056
AP2A1 6628
PICK1 3721
PRKCA 1163
GRIA4 -101
AP2B1 -2748
GRIP1 -10516


Spry regulation of FGF signaling

1152
set Spry regulation of FGF signaling
setSize 16
pANOVA 0.00107
s.dist 0.472
p.adjustANOVA 0.00428



Top enriched genes

GeneID Gene Rank
GRB2 9320
MAPK3 9078
PPP2CA 8308
MKNK1 8248
PPP2CB 7769
CBL 7599
MAPK1 7520
UBB 6737
PTPN11 5383
PPP2R1A 4669
UBC 4421
BRAF 1314
UBA52 1071
SPRY2 -4863
RPS27A -6894
SRC -9011

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 9320
MAPK3 9078
PPP2CA 8308
MKNK1 8248
PPP2CB 7769
CBL 7599
MAPK1 7520
UBB 6737
PTPN11 5383
PPP2R1A 4669
UBC 4421
BRAF 1314
UBA52 1071
SPRY2 -4863
RPS27A -6894
SRC -9011


GRB2 events in EGFR signaling

432
set GRB2 events in EGFR signaling
setSize 11
pANOVA 0.00679
s.dist 0.471
p.adjustANOVA 0.0194



Top enriched genes

GeneID Gene Rank
GRB2 9320
TGFA 9031
EGF 8267
AREG 5494
NRAS 5411
HBEGF 4878
KRAS 3760
EPGN 2579
EREG 1906
HRAS -3335
SOS1 -5714

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 9320
TGFA 9031
EGF 8267
AREG 5494
NRAS 5411
HBEGF 4878
KRAS 3760
EPGN 2579
EREG 1906
HRAS -3335
SOS1 -5714


Signaling by RAF1 mutants

1128
set Signaling by RAF1 mutants
setSize 34
pANOVA 1.98e-06
s.dist 0.471
p.adjustANOVA 2.16e-05



Top enriched genes

GeneID Gene Rank
MAPK3 9078
MAP2K1 8960
ITGA2B 8942
APBB1IP 8849
MARK3 8774
TLN1 8554
ARRB2 8517
ITGB3 8367
FN1 8294
IQGAP1 8189
RAF1 7991
MAPK1 7520
VCL 7380
RAP1A 7319
MAP2K2 6906
VWF 6607
YWHAB 6398
NRAS 5411
CSK 5285
KSR1 4113

Click HERE to show all gene set members

GeneID Gene Rank
MAPK3 9078
MAP2K1 8960
ITGA2B 8942
APBB1IP 8849
MARK3 8774
TLN1 8554
ARRB2 8517
ITGB3 8367
FN1 8294
IQGAP1 8189
RAF1 7991
MAPK1 7520
VCL 7380
RAP1A 7319
MAP2K2 6906
VWF 6607
YWHAB 6398
NRAS 5411
CSK 5285
KSR1 4113
KRAS 3760
RAP1B 3331
ARAF 2680
JAK2 2599
ARRB1 2098
CAMK2G 1888
BRAF 1314
CALM1 -2048
HRAS -3335
KSR2 -3364
CNKSR2 -4481
CNKSR1 -6858
SRC -9011
CAMK2D -11728


Josephin domain DUBs

583
set Josephin domain DUBs
setSize 10
pANOVA 0.00994
s.dist 0.471
p.adjustANOVA 0.026



Top enriched genes

GeneID Gene Rank
RAD23B 8926
JOSD2 8025
VCP 6955
UBB 6737
RAD23A 6599
UBC 4421
ATXN3 1623
UBA52 1071
JOSD1 290
RPS27A -6894

Click HERE to show all gene set members

GeneID Gene Rank
RAD23B 8926
JOSD2 8025
VCP 6955
UBB 6737
RAD23A 6599
UBC 4421
ATXN3 1623
UBA52 1071
JOSD1 290
RPS27A -6894


Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

346
set Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
setSize 11
pANOVA 0.00701
s.dist 0.469
p.adjustANOVA 0.0199



Top enriched genes

GeneID Gene Rank
PIK3CB 9065
IRS2 8323
LYN 7728
EPOR 7164
PIK3CD 6096
GAB1 5723
PIK3CA 4697
JAK2 2599
PIK3CG 2046
PIK3R5 -2346
PIK3R1 -9725

Click HERE to show all gene set members

GeneID Gene Rank
PIK3CB 9065
IRS2 8323
LYN 7728
EPOR 7164
PIK3CD 6096
GAB1 5723
PIK3CA 4697
JAK2 2599
PIK3CG 2046
PIK3R5 -2346
PIK3R1 -9725


Integrin signaling

544
set Integrin signaling
setSize 22
pANOVA 0.000139
s.dist 0.469
p.adjustANOVA 0.00075



Top enriched genes

GeneID Gene Rank
GRB2 9320
SYK 9087
ITGA2B 8942
CRK 8941
APBB1IP 8849
TLN1 8554
ITGB3 8367
FN1 8294
RAP1A 7319
VWF 6607
PDPK1 6209
PTPN1 5797
CSK 5285
PTK2 4506
SHC1 4173
AKT1 3656
RAP1B 3331
RAPGEF3 25
SOS1 -5714
RASGRP2 -8137

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 9320
SYK 9087
ITGA2B 8942
CRK 8941
APBB1IP 8849
TLN1 8554
ITGB3 8367
FN1 8294
RAP1A 7319
VWF 6607
PDPK1 6209
PTPN1 5797
CSK 5285
PTK2 4506
SHC1 4173
AKT1 3656
RAP1B 3331
RAPGEF3 25
SOS1 -5714
RASGRP2 -8137
SRC -9011
RASGRP1 -11817


Generation of second messenger molecules

445
set Generation of second messenger molecules
setSize 38
pANOVA 7.9e-07
s.dist -0.463
p.adjustANOVA 1.05e-05



Top enriched genes

GeneID Gene Rank
CD247 -12295
HLA-DPA1 -12271
HLA-DPB1 -12203
EVL -12046
HLA-DRA -12007
TRBC1 -11859
ZAP70 -11833
HLA-DQA1 -11763
LCK -11492
NCK1 -11488
CD3G -11409
LAT -11376
CD3D -11094
ITK -11066
CD3E -11042
TRAC -10981
PLCG1 -10473
TRBV12-3 -10279
TRAV19 -10023
TRBV7-9 -9564

Click HERE to show all gene set members

GeneID Gene Rank
CD247 -12295
HLA-DPA1 -12271
HLA-DPB1 -12203
EVL -12046
HLA-DRA -12007
TRBC1 -11859
ZAP70 -11833
HLA-DQA1 -11763
LCK -11492
NCK1 -11488
CD3G -11409
LAT -11376
CD3D -11094
ITK -11066
CD3E -11042
TRAC -10981
PLCG1 -10473
TRBV12-3 -10279
TRAV19 -10023
TRBV7-9 -9564
HLA-DQB2 -9390
TRAV8-4 -9384
TRAV29DV5 -9334
HLA-DRB1 -8159
HLA-DQB1 -5703
CD4 -5320
HLA-DRB5 -5140
HLA-DQA2 -4793
PAK3 -4194
ENAH -2766
LCP2 -1167
CD101 4165
GRAP2 4746
PLCG2 5103
VASP 8136
PAK2 8226
PAK1 8252
WAS 8596


Antimicrobial peptides

77
set Antimicrobial peptides
setSize 33
pANOVA 4.52e-06
s.dist 0.461
p.adjustANOVA 4.14e-05



Top enriched genes

GeneID Gene Rank
S100A9 9562
S100A8 9560
CCR2 9503
CLU 9423
SLC11A1 9152
TLR2 9069
TLR1 9041
PGLYRP1 8051
LCN2 7752
RNASE3 7744
ELANE 7303
LYZ 7202
RNASE6 6873
PRTN3 6822
BPI 6538
DEFA4 6193
LTF 6182
DEFA1 5953
DEFA3 5539
CTSG 5224

Click HERE to show all gene set members

GeneID Gene Rank
S100A9 9562
S100A8 9560
CCR2 9503
CLU 9423
SLC11A1 9152
TLR2 9069
TLR1 9041
PGLYRP1 8051
LCN2 7752
RNASE3 7744
ELANE 7303
LYZ 7202
RNASE6 6873
PRTN3 6822
BPI 6538
DEFA4 6193
LTF 6182
DEFA1 5953
DEFA3 5539
CTSG 5224
CAMP 4713
ATOX1 4439
PI3 2860
EPPIN 2431
ATP7A 647
PGLYRP2 -2301
HTN1 -3350
LEAP2 -4665
CD4 -5320
ITLN1 -6277
PDZD11 -6343
CCR6 -7086
GNLY -11505


Response of Mtb to phagocytosis

1009
set Response of Mtb to phagocytosis
setSize 22
pANOVA 0.000194
s.dist 0.459
p.adjustANOVA 0.000993



Top enriched genes

GeneID Gene Rank
MAPK3 9078
ENO1 8877
RAB7A 8775
PGK1 8681
TRIM27 8257
ATP6V1H 8119
GSK3A 7811
MAPK1 7520
RAB5A 7166
UBB 6737
CTSG 5224
CORO1A 5206
HGS 4570
UBC 4421
KPNB1 2491
SFPQ 2294
KPNA1 1320
UBA52 1071
VPS33B -2000
DUSP16 -6652

Click HERE to show all gene set members

GeneID Gene Rank
MAPK3 9078
ENO1 8877
RAB7A 8775
PGK1 8681
TRIM27 8257
ATP6V1H 8119
GSK3A 7811
MAPK1 7520
RAB5A 7166
UBB 6737
CTSG 5224
CORO1A 5206
HGS 4570
UBC 4421
KPNB1 2491
SFPQ 2294
KPNA1 1320
UBA52 1071
VPS33B -2000
DUSP16 -6652
RPS27A -6894
RNF213 -11921


EGFR downregulation

319
set EGFR downregulation
setSize 27
pANOVA 3.88e-05
s.dist 0.457
p.adjustANOVA 0.000257



Top enriched genes

GeneID Gene Rank
GRB2 9320
TGFA 9031
EGF 8267
PTPN12 8125
EPN1 8026
SH3GL1 7733
CBL 7599
CDC42 7539
UBB 6737
SH3KBP1 6227
STAM2 6183
AREG 5494
HBEGF 4878
HGS 4570
UBC 4421
EPS15 4189
EPS15L1 3688
EPGN 2579
EREG 1906
SPRY1 1831

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 9320
TGFA 9031
EGF 8267
PTPN12 8125
EPN1 8026
SH3GL1 7733
CBL 7599
CDC42 7539
UBB 6737
SH3KBP1 6227
STAM2 6183
AREG 5494
HBEGF 4878
HGS 4570
UBC 4421
EPS15 4189
EPS15L1 3688
EPGN 2579
EREG 1906
SPRY1 1831
STAM 1299
UBA52 1071
PTPN3 -46
ARHGEF7 -4627
SPRY2 -4863
PTPRK -6407
RPS27A -6894


GAB1 signalosome

423
set GAB1 signalosome
setSize 15
pANOVA 0.00221
s.dist 0.456
p.adjustANOVA 0.00785



Top enriched genes

GeneID Gene Rank
GRB2 9320
TGFA 9031
EGF 8267
PXN 6332
GAB1 5723
AREG 5494
PTPN11 5383
CSK 5285
HBEGF 4878
PIK3CA 4697
PAG1 4088
EPGN 2579
EREG 1906
SRC -9011
PIK3R1 -9725

Click HERE to show all gene set members

GeneID Gene Rank
GRB2 9320
TGFA 9031
EGF 8267
PXN 6332
GAB1 5723
AREG 5494
PTPN11 5383
CSK 5285
HBEGF 4878
PIK3CA 4697
PAG1 4088
EPGN 2579
EREG 1906
SRC -9011
PIK3R1 -9725


Diseases of programmed cell death

297
set Diseases of programmed cell death
setSize 23
pANOVA 0.000153
s.dist 0.456
p.adjustANOVA 0.000812



Top enriched genes

GeneID Gene Rank
LMNB1 9391
APP 9123
YWHAE 9009
FOXO3 8729
CDK5 8663
CAPN1 8613
CAST 8045
CAPNS1 7603
BCL2L11 7326
PRDX1 7104
GOLGA2 6217
CDC25C 5024
SOD2 4458
JUN 3964
LMNA 3863
PRDX2 3467
CDC25A 2948
CAPN2 1058
C1QBP -902
CDK5R1 -1166

Click HERE to show all gene set members

GeneID Gene Rank
LMNB1 9391
APP 9123
YWHAE 9009
FOXO3 8729
CDK5 8663
CAPN1 8613
CAST 8045
CAPNS1 7603
BCL2L11 7326
PRDX1 7104
GOLGA2 6217
CDC25C 5024
SOD2 4458
JUN 3964
LMNA 3863
PRDX2 3467
CDC25A 2948
CAPN2 1058
C1QBP -902
CDK5R1 -1166
CDKN2A -5302
CDC25B -11871
FASLG -12319


The NLRP3 inflammasome

1226
set The NLRP3 inflammasome
setSize 15
pANOVA 0.00227
s.dist 0.455
p.adjustANOVA 0.00801



Top enriched genes

GeneID Gene Rank
APP 9123
NLRP3 8813
PYCARD 8734
MEFV 8576
TXN 8414
PSTPIP1 7930
NFKB1 6367
PANX1 6189
CASP1 4086
P2RX7 3420
SUGT1 1576
NFKB2 -865
RELA -1807
HSP90AB1 -6702
TXNIP -9792

Click HERE to show all gene set members

GeneID Gene Rank
APP 9123
NLRP3 8813
PYCARD 8734
MEFV 8576
TXN 8414
PSTPIP1 7930
NFKB1 6367
PANX1 6189
CASP1 4086
P2RX7 3420
SUGT1 1576
NFKB2 -865
RELA -1807
HSP90AB1 -6702
TXNIP -9792


Response to elevated platelet cytosolic Ca2+

1010
set Response to elevated platelet cytosolic Ca2+
setSize 110
pANOVA 1.59e-16
s.dist 0.455
p.adjustANOVA 1.55e-14



Top enriched genes

GeneID Gene Rank
F5 9524
CYB5R1 9511
CD36 9486
CLU 9423
CD63 9330
QSOX1 9302
APLP2 9296
FERMT3 9287
ALDOA 9274
ACTN1 9210
SERPINA1 9179
LHFPL2 9147
APP 9123
STXBP2 9067
ITGA2B 8942
TOR4A 8938
F13A1 8919
VTI1B 8892
HGF 8856
LAMP2 8803

Click HERE to show all gene set members

GeneID Gene Rank
F5 9524
CYB5R1 9511
CD36 9486
CLU 9423
CD63 9330
QSOX1 9302
APLP2 9296
FERMT3 9287
ALDOA 9274
ACTN1 9210
SERPINA1 9179
LHFPL2 9147
APP 9123
STXBP2 9067
ITGA2B 8942
TOR4A 8938
F13A1 8919
VTI1B 8892
HGF 8856
LAMP2 8803
SRGN 8781
TIMP1 8594
CLEC3B 8592
TLN1 8554
SELP 8499
SYTL4 8410
ITGB3 8367
FN1 8294
EGF 8267
CFL1 8242
CAP1 8200
GAS6 8164
LY6G6F 8148
ANXA5 8122
ORM1 8082
SCCPDH 7913
CALU 7894
PROS1 7763
MMRN1 7746
PECAM1 7743
SERPINE1 7580
ABCC4 7559
TAGLN2 7451
STXBP3 7442
SPARC 7411
VEGFA 7389
VCL 7380
HSPA5 7118
VEGFC 7057
PRKCB 7056
WDR1 7052
F8 6996
PSAP 6909
VWF 6607
TUBA4A 6587
TMSB4X 6399
GTPBP2 6377
PPBP 6029
CD9 6004
THBS1 5946
PF4 5777
A1BG 5617
PFN1 5562
PHACTR2 5504
PDGFA 5484
ECM1 5213
TGFB1 5201
ACTN4 5132
OLA1 4999
CD109 4343
RAB27B 3588
TIMP3 3463
ENDOD1 3416
ALB 3339
CHID1 2811
MANF 2532
PLEK 2120
CFD 2016
APOOL 1644
TTN 1246
TF 1172
PRKCA 1163
STX4 626
FLNA 547
TMX3 -800
PCYOX1L -1974
PLG -1998
CALM1 -2048
ORM2 -2594
MAGED2 -2729
ITIH3 -2982
SOD1 -4927
ITIH4 -6217
BRPF3 -6480
SERPINF2 -6601
PPIA -6900
SELENOP -7304
TGFB2 -7546
TGFB3 -7674
NHLRC2 -7843
VEGFB -7866
CDC37L1 -8413
TEX264 -8472
PDGFB -8575
A2M -9822
FAM3C -10007
HABP4 -10972
CTSW -11238
SERPING1 -11444
LGALS3BP -11611


activated TAK1 mediates p38 MAPK activation

1330
set activated TAK1 mediates p38 MAPK activation
setSize 19
pANOVA 0.000606
s.dist 0.454
p.adjustANOVA 0.00269



Top enriched genes

GeneID Gene Rank
MAPK14 9219
MAP2K6 9010
MAP2K3 8785
NOD2 8393
MAPKAPK3 8255
TAB2 7070
IRAK1 6159
TAB1 5711
UBE2V1 5681
IKBKG 5434
MAPKAPK2 4176
MAPK11 3955
TAB3 3165
MAP3K7 2453
UBE2N 1951
RIPK2 1042
TRAF6 -241
IRAK2 -9718
NOD1 -12234

Click HERE to show all gene set members

GeneID Gene Rank
MAPK14 9219
MAP2K6 9010
MAP2K3 8785
NOD2 8393
MAPKAPK3 8255
TAB2 7070
IRAK1 6159
TAB1 5711
UBE2V1 5681
IKBKG 5434
MAPKAPK2 4176
MAPK11 3955
TAB3 3165
MAP3K7 2453
UBE2N 1951
RIPK2 1042
TRAF6 -241
IRAK2 -9718
NOD1 -12234


Lagging Strand Synthesis

592
set Lagging Strand Synthesis
setSize 20
pANOVA 0.000438
s.dist -0.454
p.adjustANOVA 0.00205



Top enriched genes

GeneID Gene Rank
POLA1 -12121
RPA1 -11962
RFC5 -11754
POLA2 -11639
FEN1 -10740
RFC3 -10515
RFC4 -10511
LIG1 -10471
PRIM1 -10176
POLD2 -9925
RPA3 -9003
RFC1 -7529
RPA2 -6397
PCNA -6038
PRIM2 -5619
DNA2 -2882
POLD1 133
RFC2 5040
POLD4 6429
POLD3 8712

Click HERE to show all gene set members

GeneID Gene Rank
POLA1 -12121
RPA1 -11962
RFC5 -11754
POLA2 -11639
FEN1 -10740
RFC3 -10515
RFC4 -10511
LIG1 -10471
PRIM1 -10176
POLD2 -9925
RPA3 -9003
RFC1 -7529
RPA2 -6397
PCNA -6038
PRIM2 -5619
DNA2 -2882
POLD1 133
RFC2 5040
POLD4 6429
POLD3 8712


Platelet degranulation

831
set Platelet degranulation
setSize 106
pANOVA 7.21e-16
s.dist 0.453
p.adjustANOVA 6.56e-14



Top enriched genes

GeneID Gene Rank
F5 9524
CYB5R1 9511
CD36 9486
CLU 9423
CD63 9330
QSOX1 9302
APLP2 9296
FERMT3 9287
ALDOA 9274
ACTN1 9210
SERPINA1 9179
LHFPL2 9147
APP 9123
STXBP2 9067
ITGA2B 8942
TOR4A 8938
F13A1 8919
VTI1B 8892
HGF 8856
LAMP2 8803

Click HERE to show all gene set members

GeneID Gene Rank
F5 9524
CYB5R1 9511
CD36 9486
CLU 9423
CD63 9330
QSOX1 9302
APLP2 9296
FERMT3 9287
ALDOA 9274
ACTN1 9210
SERPINA1 9179
LHFPL2 9147
APP 9123
STXBP2 9067
ITGA2B 8942
TOR4A 8938
F13A1 8919
VTI1B 8892
HGF 8856
LAMP2 8803
SRGN 8781
TIMP1 8594
CLEC3B 8592
TLN1 8554
SELP 8499
SYTL4 8410
ITGB3 8367
FN1 8294
EGF 8267
CFL1 8242
CAP1 8200
GAS6 8164
LY6G6F 8148
ANXA5 8122
ORM1 8082
SCCPDH 7913
CALU 7894
PROS1 7763
MMRN1 7746
PECAM1 7743
SERPINE1 7580
ABCC4 7559
TAGLN2 7451
SPARC 7411
VEGFA 7389
VCL 7380
HSPA5 7118
VEGFC 7057
WDR1 7052
F8 6996
PSAP 6909
VWF 6607
TUBA4A 6587
TMSB4X 6399
GTPBP2 6377
PPBP 6029
CD9 6004
THBS1 5946
PF4 5777
A1BG 5617
PFN1 5562
PHACTR2 5504
PDGFA 5484
ECM1 5213
TGFB1 5201
ACTN4 5132
OLA1 4999
CD109 4343
RAB27B 3588
TIMP3 3463
ENDOD1 3416
ALB 3339
CHID1 2811
MANF 2532
PLEK 2120
CFD 2016
APOOL 1644
TTN 1246
TF 1172
FLNA 547
TMX3 -800
PCYOX1L -1974
PLG -1998
CALM1 -2048
ORM2 -2594
MAGED2 -2729
ITIH3 -2982
SOD1 -4927
ITIH4 -6217
BRPF3 -6480
SERPINF2 -6601
PPIA -6900
SELENOP -7304
TGFB2 -7546
TGFB3 -7674
NHLRC2 -7843
VEGFB -7866
CDC37L1 -8413
TEX264 -8472
PDGFB -8575
A2M -9822
FAM3C -10007
HABP4 -10972
CTSW -11238
SERPING1 -11444
LGALS3BP -11611


Packaging Of Telomere Ends

802
set Packaging Of Telomere Ends
setSize 20
pANOVA 0.000467
s.dist 0.452
p.adjustANOVA 0.00218



Top enriched genes

GeneID Gene Rank
H2AJ 9418
H2BC21 9368
H2BC12 9178
H2BC5 8163
H2BC11 8076
H2AC6 8070
H2BC4 7549
H2BC17 7502
H2AZ1 6126
H2BC9 5461
H2BC15 5458
TERF2IP 5118
H2AC20 5039
TINF2 4667
H2AZ2 -1266
TERF1 -3548
POT1 -4395
TERF2 -4515
H2BU1 -6519
ACD -7630

Click HERE to show all gene set members

GeneID Gene Rank
H2AJ 9418
H2BC21 9368
H2BC12 9178
H2BC5 8163
H2BC11 8076
H2AC6 8070
H2BC4 7549
H2BC17 7502
H2AZ1 6126
H2BC9 5461
H2BC15 5458
TERF2IP 5118
H2AC20 5039
TINF2 4667
H2AZ2 -1266
TERF1 -3548
POT1 -4395
TERF2 -4515
H2BU1 -6519
ACD -7630


IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

512
set IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
setSize 15
pANOVA 0.00247
s.dist 0.451
p.adjustANOVA 0.00856



Top enriched genes

GeneID Gene Rank
CD14 9164
TLR4 8981
LY96 8871
TAB2 7070
UBB 6737
TICAM1 6380
TICAM2 6244
TAB1 5711
UBC 4421
TAB3 3165
MAP3K7 2453
UBA52 1071
TRAF6 -241
RPS27A -6894
IRAK2 -9718

Click HERE to show all gene set members

GeneID Gene Rank
CD14 9164
TLR4 8981
LY96 8871
TAB2 7070
UBB 6737
TICAM1 6380
TICAM2 6244
TAB1 5711
UBC 4421
TAB3 3165
MAP3K7 2453
UBA52 1071
TRAF6 -241
RPS27A -6894
IRAK2 -9718


Prolonged ERK activation events

863
set Prolonged ERK activation events
setSize 13
pANOVA 0.00485
s.dist 0.451
p.adjustANOVA 0.0147



Top enriched genes

GeneID Gene Rank
MAPK3 9078
MAP2K1 8960
CRK 8941
MAPK1 7520
RAP1A 7319
KIDINS220 7111
MAP2K2 6906
YWHAB 6398
CRKL 3986
BRAF 1314
FRS2 -3430
NTRK1 -7791
RAPGEF1 -10033

Click HERE to show all gene set members

GeneID Gene Rank
MAPK3 9078
MAP2K1 8960
CRK 8941
MAPK1 7520
RAP1A 7319
KIDINS220 7111
MAP2K2 6906
YWHAB 6398
CRKL 3986
BRAF 1314
FRS2 -3430
NTRK1 -7791
RAPGEF1 -10033


Mucopolysaccharidoses

683
set Mucopolysaccharidoses
setSize 11
pANOVA 0.00995
s.dist 0.449
p.adjustANOVA 0.026



Top enriched genes

GeneID Gene Rank
GNS 9309
GLB1 8652
GUSB 7454
ARSB 7373
GALNS 7183
SGSH 5984
HYAL1 4297
HGSNAT 1871
IDS -2609
NAGLU -4826
IDUA -5812

Click HERE to show all gene set members

GeneID Gene Rank
GNS 9309
GLB1 8652
GUSB 7454
ARSB 7373
GALNS 7183
SGSH 5984
HYAL1 4297
HGSNAT 1871
IDS -2609
NAGLU -4826
IDUA -5812


WNT5A-dependent internalization of FZD4

1325
set WNT5A-dependent internalization of FZD4
setSize 13
pANOVA 0.00511
s.dist 0.448
p.adjustANOVA 0.0154



Top enriched genes

GeneID Gene Rank
CLTC 9056
AP2M1 8673
ARRB2 8517
CLTA 8402
AP2S1 8080
AP2A2 7360
PRKCB 7056
AP2A1 6628
CLTB 6195
PRKCA 1163
AP2B1 -2748
DVL2 -10753
FZD4 -11733

Click HERE to show all gene set members

GeneID Gene Rank
CLTC 9056
AP2M1 8673
ARRB2 8517
CLTA 8402
AP2S1 8080
AP2A2 7360
PRKCB 7056
AP2A1 6628
CLTB 6195
PRKCA 1163
AP2B1 -2748
DVL2 -10753
FZD4 -11733


Infection with Mycobacterium tuberculosis

524
set Infection with Mycobacterium tuberculosis
setSize 26
pANOVA 7.67e-05
s.dist 0.448
p.adjustANOVA 0.000463



Top enriched genes

GeneID Gene Rank
MAPK3 9078
TLR2 9069
ENO1 8877
RAB7A 8775
PGK1 8681
TRIM27 8257
ATP6V1H 8119
GSK3A 7811
MAPK1 7520
RAB5A 7166
UBB 6737
LTF 6182
CTSG 5224
CORO1A 5206
HGS 4570
UBC 4421
MRC1 3187
KPNB1 2491
SFPQ 2294
KPNA1 1320

Click HERE to show all gene set members

GeneID Gene Rank
MAPK3 9078
TLR2 9069
ENO1 8877
RAB7A 8775
PGK1 8681
TRIM27 8257
ATP6V1H 8119
GSK3A 7811
MAPK1 7520
RAB5A 7166
UBB 6737
LTF 6182
CTSG 5224
CORO1A 5206
HGS 4570
UBC 4421
MRC1 3187
KPNB1 2491
SFPQ 2294
KPNA1 1320
UBA52 1071
VPS33B -2000
DUSP16 -6652
RPS27A -6894
B2M -7019
RNF213 -11921


Resolution of AP sites via the multiple-nucleotide patch replacement pathway

999
set Resolution of AP sites via the multiple-nucleotide patch replacement pathway
setSize 24
pANOVA 0.000152
s.dist -0.447
p.adjustANOVA 0.000808



Top enriched genes

GeneID Gene Rank
PARP2 -12127
RPA1 -11962
RFC5 -11754
POLE3 -11643
PARP1 -11586
FEN1 -10740
RFC3 -10515
RFC4 -10511
LIG1 -10471
POLE2 -10111
APEX1 -10057
POLD2 -9925
RPA3 -9003
POLB -7666
POLE -7577
RFC1 -7529
RPA2 -6397
PCNA -6038
PARG -699
POLD1 133

Click HERE to show all gene set members

GeneID Gene Rank
PARP2 -12127
RPA1 -11962
RFC5 -11754
POLE3 -11643
PARP1 -11586
FEN1 -10740
RFC3 -10515
RFC4 -10511
LIG1 -10471
POLE2 -10111
APEX1 -10057
POLD2 -9925
RPA3 -9003
POLB -7666
POLE -7577
RFC1 -7529
RPA2 -6397
PCNA -6038
PARG -699
POLD1 133
RFC2 5040
POLE4 5612
POLD4 6429
POLD3 8712


ATF6 (ATF6-alpha) activates chaperone genes

20
set ATF6 (ATF6-alpha) activates chaperone genes
setSize 10
pANOVA 0.0147
s.dist 0.446
p.adjustANOVA 0.0353



Top enriched genes

GeneID Gene Rank
ATF6 8461
NFYC 7726
HSPA5 7118
CALR 6415
ATF4 6317
DDIT3 4938
NFYA 3506
HSP90B1 2086
XBP1 -1602
NFYB -9957

Click HERE to show all gene set members

GeneID Gene Rank
ATF6 8461
NFYC 7726
HSPA5 7118
CALR 6415
ATF4 6317
DDIT3 4938
NFYA 3506
HSP90B1 2086
XBP1 -1602
NFYB -9957


Membrane binding and targetting of GAG proteins

632
set Membrane binding and targetting of GAG proteins
setSize 13
pANOVA 0.00544
s.dist 0.445
p.adjustANOVA 0.0161



Top enriched genes

GeneID Gene Rank
UBAP1 8779
VPS37C 7973
TSG101 7856
MVB12A 7425
UBB 6737
VPS37A 6560
MVB12B 5251
UBC 4421
VPS28 4247
VPS37B 3933
UBA52 1071
RPS27A -6894
NMT2 -11923

Click HERE to show all gene set members

GeneID Gene Rank
UBAP1 8779
VPS37C 7973
TSG101 7856
MVB12A 7425
UBB 6737
VPS37A 6560
MVB12B 5251
UBC 4421
VPS28 4247
VPS37B 3933
UBA52 1071
RPS27A -6894
NMT2 -11923


Synthesis And Processing Of GAG, GAGPOL Polyproteins

1162
set Synthesis And Processing Of GAG, GAGPOL Polyproteins
setSize 13
pANOVA 0.00544
s.dist 0.445
p.adjustANOVA 0.0161



Top enriched genes

GeneID Gene Rank
UBAP1 8779
VPS37C 7973
TSG101 7856
MVB12A 7425
UBB 6737
VPS37A 6560
MVB12B 5251
UBC 4421
VPS28 4247
VPS37B 3933
UBA52 1071
RPS27A -6894
NMT2 -11923

Click HERE to show all gene set members

GeneID Gene Rank
UBAP1 8779
VPS37C 7973
TSG101 7856
MVB12A 7425
UBB 6737
VPS37A 6560
MVB12B 5251
UBC 4421
VPS28 4247
VPS37B 3933
UBA52 1071
RPS27A -6894
NMT2 -11923


Biotin transport and metabolism

114
set Biotin transport and metabolism
setSize 11
pANOVA 0.0107
s.dist -0.444
p.adjustANOVA 0.0277



Top enriched genes

GeneID Gene Rank
BTD -12100
MCCC2 -11850
HLCS -11768
ACACB -9846
MCCC1 -9147
PCCA -8821
PCCB -8040
PDZD11 -6343
SLC5A6 -5458
ACACA 5394
PC 9322

Click HERE to show all gene set members

GeneID Gene Rank
BTD -12100
MCCC2 -11850
HLCS -11768
ACACB -9846
MCCC1 -9147
PCCA -8821
PCCB -8040
PDZD11 -6343
SLC5A6 -5458
ACACA 5394
PC 9322


MyD88:MAL(TIRAP) cascade initiated on plasma membrane

689
set MyD88:MAL(TIRAP) cascade initiated on plasma membrane
setSize 92
pANOVA 3.67e-13
s.dist 0.438
p.adjustANOVA 1.79e-11



Top enriched genes

GeneID Gene Rank
S100A12 9567
CD36 9486
DUSP3 9324
NKIRAS2 9308
MAPK14 9219
CD14 9164
APP 9123
MAPK3 9078
TLR2 9069
TLR1 9041
MAP2K6 9010
TLR4 8981
MAP2K1 8960
IRAK3 8947
TLR6 8931
LY96 8871
MAP2K3 8785
NOD2 8393
PPP2CA 8308
MAPKAPK3 8255

Click HERE to show all gene set members

GeneID Gene Rank
S100A12 9567
CD36 9486
DUSP3 9324
NKIRAS2 9308
MAPK14 9219
CD14 9164
APP 9123
MAPK3 9078
TLR2 9069
TLR1 9041
MAP2K6 9010
TLR4 8981
MAP2K1 8960
IRAK3 8947
TLR6 8931
LY96 8871
MAP2K3 8785
NOD2 8393
PPP2CA 8308
MAPKAPK3 8255
PELI2 8166
MYD88 8091
MEF2A 8030
CHUK 7959
RPS6KA1 7800
PPP2CB 7769
PELI3 7736
MAPK1 7520
BTK 7156
TAB2 7070
MAP2K4 6948
NFKBIA 6835
UBB 6737
PELI1 6596
NFKB1 6367
FBXW11 6282
MAP3K8 6262
FOS 6179
IRAK1 6159
ATF1 5790
TAB1 5711
TIRAP 5700
UBE2V1 5681
TNIP2 5630
IKBKG 5434
MAP3K1 5160
ECSIT 4997
PPP2R1A 4669
UBC 4421
DUSP6 4367
SKP1 4349
MAPKAPK2 4176
MAPK10 4136
JUN 3964
MAPK11 3955
SOCS1 3886
RPS6KA2 3177
TAB3 3165
RPS6KA3 3012
MAP3K7 2453
PPP2R5D 2440
ATF2 2110
UBE2N 1951
MAP2K7 1647
AGER 1309
VRK3 1293
UBA52 1071
RIPK2 1042
ELK1 1040
NKIRAS1 387
NFKBIB -88
HMGB1 -200
TRAF6 -241
PPP2R1B -246
MEF2C -319
NFKB2 -865
MAPK7 -1294
CREB1 -1382
RELA -1807
DUSP7 -3253
BTRC -4932
S100B -5025
IKBKB -5290
DUSP4 -6432
RPS27A -6894
MAPK9 -7182
MAPK8 -9646
IRAK2 -9718
SIGIRR -10688
CUL1 -11467
RPS6KA5 -11616
NOD1 -12234


Toll Like Receptor 2 (TLR2) Cascade

1237
set Toll Like Receptor 2 (TLR2) Cascade
setSize 92
pANOVA 3.67e-13
s.dist 0.438
p.adjustANOVA 1.79e-11



Top enriched genes

GeneID Gene Rank
S100A12 9567
CD36 9486
DUSP3 9324
NKIRAS2 9308
MAPK14 9219
CD14 9164
APP 9123
MAPK3 9078
TLR2 9069
TLR1 9041
MAP2K6 9010
TLR4 8981
MAP2K1 8960
IRAK3 8947
TLR6 8931
LY96 8871
MAP2K3 8785
NOD2 8393
PPP2CA 8308
MAPKAPK3 8255

Click HERE to show all gene set members

GeneID Gene Rank
S100A12 9567
CD36 9486
DUSP3 9324
NKIRAS2 9308
MAPK14 9219
CD14 9164
APP 9123
MAPK3 9078
TLR2 9069
TLR1 9041
MAP2K6 9010
TLR4 8981
MAP2K1 8960
IRAK3 8947
TLR6 8931
LY96 8871
MAP2K3 8785
NOD2 8393
PPP2CA 8308
MAPKAPK3 8255
PELI2 8166
MYD88 8091
MEF2A 8030
CHUK 7959
RPS6KA1 7800
PPP2CB 7769
PELI3 7736
MAPK1 7520
BTK 7156
TAB2 7070
MAP2K4 6948
NFKBIA 6835
UBB 6737
PELI1 6596
NFKB1 6367
FBXW11 6282
MAP3K8 6262
FOS 6179
IRAK1 6159
ATF1 5790
TAB1 5711
TIRAP 5700
UBE2V1 5681
TNIP2 5630
IKBKG 5434
MAP3K1 5160
ECSIT 4997
PPP2R1A 4669
UBC 4421
DUSP6 4367
SKP1 4349
MAPKAPK2 4176
MAPK10 4136
JUN 3964
MAPK11 3955
SOCS1 3886
RPS6KA2 3177
TAB3 3165
RPS6KA3 3012
MAP3K7 2453
PPP2R5D 2440
ATF2 2110
UBE2N 1951
MAP2K7 1647
AGER 1309
VRK3 1293
UBA52 1071
RIPK2 1042
ELK1 1040
NKIRAS1 387
NFKBIB -88
HMGB1 -200
TRAF6 -241
PPP2R1B -246
MEF2C -319
NFKB2 -865
MAPK7 -1294
CREB1 -1382
RELA -1807
DUSP7 -3253
BTRC -4932
S100B -5025
IKBKB -5290
DUSP4 -6432
RPS27A -6894
MAPK9 -7182
MAPK8 -9646
IRAK2 -9718
SIGIRR -10688
CUL1 -11467
RPS6KA5 -11616
NOD1 -12234


Toll Like Receptor TLR1:TLR2 Cascade

1243
set Toll Like Receptor TLR1:TLR2 Cascade
setSize 92
pANOVA 3.67e-13
s.dist 0.438
p.adjustANOVA 1.79e-11



Top enriched genes

GeneID Gene Rank
S100A12 9567
CD36 9486
DUSP3 9324
NKIRAS2 9308
MAPK14 9219
CD14 9164
APP 9123
MAPK3 9078
TLR2 9069
TLR1 9041
MAP2K6 9010
TLR4 8981
MAP2K1 8960
IRAK3 8947
TLR6 8931
LY96 8871
MAP2K3 8785
NOD2 8393
PPP2CA 8308
MAPKAPK3 8255

Click HERE to show all gene set members

GeneID Gene Rank
S100A12 9567
CD36 9486
DUSP3 9324
NKIRAS2 9308
MAPK14 9219
CD14 9164
APP 9123
MAPK3 9078
TLR2 9069
TLR1 9041
MAP2K6 9010
TLR4 8981
MAP2K1 8960
IRAK3 8947
TLR6 8931
LY96 8871
MAP2K3 8785
NOD2 8393
PPP2CA 8308
MAPKAPK3 8255
PELI2 8166
MYD88 8091
MEF2A 8030
CHUK 7959
RPS6KA1 7800
PPP2CB 7769
PELI3 7736
MAPK1 7520
BTK 7156
TAB2 7070
MAP2K4 6948
NFKBIA 6835
UBB 6737
PELI1 6596
NFKB1 6367
FBXW11 6282
MAP3K8 6262
FOS 6179
IRAK1 6159
ATF1 5790
TAB1 5711
TIRAP 5700
UBE2V1 5681
TNIP2 5630
IKBKG 5434
MAP3K1 5160
ECSIT 4997
PPP2R1A 4669
UBC 4421
DUSP6 4367
SKP1 4349
MAPKAPK2 4176
MAPK10 4136
JUN 3964
MAPK11 3955
SOCS1 3886
RPS6KA2 3177
TAB3 3165
RPS6KA3 3012
MAP3K7 2453
PPP2R5D 2440
ATF2 2110
UBE2N 1951
MAP2K7 1647
AGER 1309
VRK3 1293
UBA52 1071
RIPK2 1042
ELK1 1040
NKIRAS1 387
NFKBIB -88
HMGB1 -200
TRAF6 -241
PPP2R1B -246
MEF2C -319
NFKB2 -865
MAPK7 -1294
CREB1 -1382
RELA -1807
DUSP7 -3253
BTRC -4932
S100B -5025
IKBKB -5290
DUSP4 -6432
RPS27A -6894
MAPK9 -7182
MAPK8 -9646
IRAK2 -9718
SIGIRR -10688
CUL1 -11467
RPS6KA5 -11616
NOD1 -12234


Toll Like Receptor TLR6:TLR2 Cascade

1244
set Toll Like Receptor TLR6:TLR2 Cascade
setSize 92
pANOVA 3.67e-13
s.dist 0.438
p.adjustANOVA 1.79e-11



Top enriched genes

GeneID Gene Rank
S100A12 9567
CD36 9486
DUSP3 9324
NKIRAS2 9308
MAPK14 9219
CD14 9164
APP 9123
MAPK3 9078
TLR2 9069
TLR1 9041
MAP2K6 9010
TLR4 8981
MAP2K1 8960
IRAK3 8947
TLR6 8931
LY96 8871
MAP2K3 8785
NOD2 8393
PPP2CA 8308
MAPKAPK3 8255

Click HERE to show all gene set members

GeneID Gene Rank
S100A12 9567
CD36 9486
DUSP3 9324
NKIRAS2 9308
MAPK14 9219
CD14 9164
APP 9123
MAPK3 9078
TLR2 9069
TLR1 9041
MAP2K6 9010
TLR4 8981
MAP2K1 8960
IRAK3 8947
TLR6 8931
LY96 8871
MAP2K3 8785
NOD2 8393
PPP2CA 8308
MAPKAPK3 8255
PELI2 8166
MYD88 8091
MEF2A 8030
CHUK 7959
RPS6KA1 7800
PPP2CB 7769
PELI3 7736
MAPK1 7520
BTK 7156
TAB2 7070
MAP2K4 6948
NFKBIA 6835
UBB 6737
PELI1 6596
NFKB1 6367
FBXW11 6282
MAP3K8 6262
FOS 6179
IRAK1 6159
ATF1 5790
TAB1 5711
TIRAP 5700
UBE2V1 5681
TNIP2 5630
IKBKG 5434
MAP3K1 5160
ECSIT 4997
PPP2R1A 4669
UBC 4421
DUSP6 4367
SKP1 4349
MAPKAPK2 4176
MAPK10 4136
JUN 3964
MAPK11 3955
SOCS1 3886
RPS6KA2 3177
TAB3 3165
RPS6KA3 3012
MAP3K7 2453
PPP2R5D 2440
ATF2 2110
UBE2N 1951
MAP2K7 1647
AGER 1309
VRK3 1293
UBA52 1071
RIPK2 1042
ELK1 1040
NKIRAS1 387
NFKBIB -88
HMGB1 -200
TRAF6 -241
PPP2R1B -246
MEF2C -319
NFKB2 -865
MAPK7 -1294
CREB1 -1382
RELA -1807
DUSP7 -3253
BTRC -4932
S100B -5025
IKBKB -5290
DUSP4 -6432
RPS27A -6894
MAPK9 -7182
MAPK8 -9646
IRAK2 -9718
SIGIRR -10688
CUL1 -11467
RPS6KA5 -11616
NOD1 -12234


Suppression of phagosomal maturation

1157
set Suppression of phagosomal maturation
setSize 12
pANOVA 0.00862
s.dist 0.438
p.adjustANOVA 0.0236



Top enriched genes

GeneID Gene Rank
RAB7A 8775
ATP6V1H 8119
RAB5A 7166
UBB 6737
CORO1A 5206
HGS 4570
UBC 4421
KPNB1 2491
KPNA1 1320
UBA52 1071
VPS33B -2000
RPS27A -6894

Click HERE to show all gene set members

GeneID Gene Rank
RAB7A 8775
ATP6V1H 8119
RAB5A 7166
UBB 6737
CORO1A 5206
HGS 4570
UBC 4421
KPNB1 2491
KPNA1 1320
UBA52 1071
VPS33B -2000
RPS27A -6894


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.4                
##  [7] MASS_7.3-51.6               fgsea_1.14.0               
##  [9] gplots_3.0.3                DESeq2_1.28.1              
## [11] SummarizedExperiment_1.18.1 DelayedArray_0.14.0        
## [13] matrixStats_0.56.0          Biobase_2.48.0             
## [15] GenomicRanges_1.40.0        GenomeInfoDb_1.24.2        
## [17] IRanges_2.22.2              S4Vectors_0.26.1           
## [19] BiocGenerics_0.34.0         reshape2_1.4.4             
## [21] forcats_0.5.0               stringr_1.4.0              
## [23] dplyr_1.0.0                 purrr_0.3.4                
## [25] readr_1.3.1                 tidyr_1.1.0                
## [27] tibble_3.0.1                ggplot2_3.3.2              
## [29] tidyverse_1.3.0            
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.1               rstudioapi_0.11       
##  [7] farver_2.0.3           bit64_0.9-7            AnnotationDbi_1.50.0  
## [10] fansi_0.4.1            lubridate_1.7.9        xml2_1.3.2            
## [13] splines_4.0.2          geneplotter_1.66.0     knitr_1.28            
## [16] jsonlite_1.6.1         broom_0.5.6            annotate_1.66.0       
## [19] dbplyr_1.4.4           shiny_1.4.0.2          compiler_4.0.2        
## [22] httr_1.4.1             backports_1.1.8        fastmap_1.0.1         
## [25] assertthat_0.2.1       Matrix_1.2-18          cli_2.0.2             
## [28] later_1.1.0.1          htmltools_0.5.0        tools_4.0.2           
## [31] gtable_0.3.0           glue_1.4.1             GenomeInfoDbData_1.2.3
## [34] fastmatch_1.1-0        Rcpp_1.0.4.6           cellranger_1.1.0      
## [37] vctrs_0.3.1            gdata_2.18.0           nlme_3.1-148          
## [40] xfun_0.15              testthat_2.3.2         rvest_0.3.5           
## [43] mime_0.9               lifecycle_0.2.0        XML_3.99-0.3          
## [46] zlibbioc_1.34.0        scales_1.1.1           promises_1.1.1        
## [49] hms_0.5.3              RColorBrewer_1.1-2     yaml_2.2.1            
## [52] memoise_1.1.0          gridExtra_2.3          reshape_0.8.8         
## [55] stringi_1.4.6          RSQLite_2.2.0          highr_0.8             
## [58] genefilter_1.70.0      desc_1.2.0             caTools_1.18.0        
## [61] BiocParallel_1.22.0    rlang_0.4.6            pkgconfig_2.0.3       
## [64] bitops_1.0-6           evaluate_0.14          lattice_0.20-41       
## [67] labeling_0.3           htmlwidgets_1.5.1      bit_1.1-15.2          
## [70] tidyselect_1.1.0       plyr_1.8.6             magrittr_1.5          
## [73] R6_2.4.1               generics_0.0.2         DBI_1.1.0             
## [76] pillar_1.4.4           haven_2.3.1            withr_2.2.0           
## [79] survival_3.2-3         RCurl_1.98-1.2         modelr_0.1.8          
## [82] crayon_1.3.4           KernSmooth_2.23-17     rmarkdown_2.3         
## [85] locfit_1.5-9.4         grid_4.0.2             readxl_1.3.1          
## [88] data.table_1.12.8      blob_1.2.1             reprex_0.3.0          
## [91] digest_0.6.25          pbmcapply_1.5.0        xtable_1.8-4          
## [94] httpuv_1.5.4           munsell_0.5.0

END of report