date generated: 2020-10-07

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             clus_0    clus_1     clus_2     clus_3     clus_4
## ADRA2A    306.4644        NA  -9.384027 -70.310973  -51.68441
## GAL       306.4644 -31.39679 -55.193734  -1.320342  -66.06683
## BAIAP2L2  306.4644 -39.46899 -53.821741         NA  -43.30152
## LYAR      306.4644 -63.85702         NA         NA -151.79865
## ATP5F1E  -286.0978        NA         NA  85.149859         NA
## CD63     -286.0978        NA -14.442367 121.889583   57.78314

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 1528
duplicated_genes_present 0
num_profile_genes_in_sets 1035
num_profile_genes_not_in_sets 493

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2408
num_genesets_excluded 2024
num_genesets_included 384

Genes by sector
clus_0 clus_1 clus_2 clus_3 clus_4 Count
1 1 -1 -1 -1 -1 1
2 1 -1 1 -1 -1 5
3 -1 1 -1 1 -1 3
4 -1 -1 -1 -1 1 3
5 -1 0 0 -1 1 1
6 -1 -1 -1 0 1 1
7 -1 1 -1 1 1 1
Number of significant gene sets (FDR<0.05)= 9

Gene sets by sector


Gene sets by sector
s.clus_0 s.clus_1 s.clus_2 s.clus_3 s.clus_4 Count
1 -1 -1 1 -1 -1 1
2 1 -1 1 -1 -1 6
3 1 1 1 -1 -1 1
4 -1 1 -1 -1 1 1

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 10 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.clus_0 s.clus_1 s.clus_2 s.clus_3 s.clus_4 p.clus_0 p.clus_1 p.clus_2 p.clus_3 p.clus_4
B-WICH complex positively regulates rRNA expression 8 5.07e-06 2.59e-05 0.274 0.1110 -0.0101 0.0365 -0.0309 -0.2460 0.913 0.000207 0.044 0.358 0.400
Developmental Biology 157 5.07e-06 2.59e-05 0.181 -0.0591 0.1380 -0.0638 -0.0597 0.0492 0.913 0.000207 0.044 0.358 0.400
Epigenetic regulation of gene expression 14 5.07e-06 2.59e-05 0.282 0.1050 -0.0327 0.0890 -0.0309 -0.2420 0.913 0.000207 0.044 0.358 0.400
Gene expression (Transcription) 145 5.07e-06 2.59e-05 0.207 0.0746 -0.0303 0.0951 -0.0527 -0.1570 0.913 0.000207 0.044 0.358 0.400
Generic Transcription Pathway 110 5.07e-06 2.59e-05 0.114 -0.0057 -0.0263 0.0758 -0.0362 -0.0728 0.913 0.000207 0.044 0.358 0.400
Positive epigenetic regulation of rRNA expression 11 5.07e-06 2.59e-05 0.252 0.1110 -0.0101 0.0890 -0.0309 -0.2050 0.913 0.000207 0.044 0.358 0.400
RNA Polymerase II Transcription 130 5.07e-06 2.59e-05 0.162 0.0482 -0.0308 0.0829 -0.0381 -0.1210 0.913 0.000207 0.044 0.358 0.400
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 9 5.07e-06 2.59e-05 0.349 0.0698 -0.0405 0.1330 -0.1310 -0.2840 0.913 0.000207 0.044 0.358 0.400
Transcriptional regulation of granulopoiesis 7 5.07e-06 2.59e-05 0.464 0.3040 0.0154 0.2530 -0.1310 -0.2030 0.913 0.000207 0.044 0.358 0.400
IRE1alpha activates chaperones 9 8.07e-02 3.09e-01 0.229 0.0730 0.0441 0.1010 -0.0970 0.1600 0.222 0.205000 0.415 0.249 0.863


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.clus_0 s.clus_1 s.clus_2 s.clus_3 s.clus_4 p.clus_0 p.clus_1 p.clus_2 p.clus_3 p.clus_4
B-WICH complex positively regulates rRNA expression 8 5.07e-06 2.59e-05 0.2740 0.11100 -0.010100 0.036500 -0.030900 -0.24600 0.9130 0.000207 0.044 0.3580 0.40000
Developmental Biology 157 5.07e-06 2.59e-05 0.1810 -0.05910 0.138000 -0.063800 -0.059700 0.04920 0.9130 0.000207 0.044 0.3580 0.40000
Epigenetic regulation of gene expression 14 5.07e-06 2.59e-05 0.2820 0.10500 -0.032700 0.089000 -0.030900 -0.24200 0.9130 0.000207 0.044 0.3580 0.40000
Gene expression (Transcription) 145 5.07e-06 2.59e-05 0.2070 0.07460 -0.030300 0.095100 -0.052700 -0.15700 0.9130 0.000207 0.044 0.3580 0.40000
Generic Transcription Pathway 110 5.07e-06 2.59e-05 0.1140 -0.00570 -0.026300 0.075800 -0.036200 -0.07280 0.9130 0.000207 0.044 0.3580 0.40000
Positive epigenetic regulation of rRNA expression 11 5.07e-06 2.59e-05 0.2520 0.11100 -0.010100 0.089000 -0.030900 -0.20500 0.9130 0.000207 0.044 0.3580 0.40000
RNA Polymerase II Transcription 130 5.07e-06 2.59e-05 0.1620 0.04820 -0.030800 0.082900 -0.038100 -0.12100 0.9130 0.000207 0.044 0.3580 0.40000
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 9 5.07e-06 2.59e-05 0.3490 0.06980 -0.040500 0.133000 -0.131000 -0.28400 0.9130 0.000207 0.044 0.3580 0.40000
Transcriptional regulation of granulopoiesis 7 5.07e-06 2.59e-05 0.4640 0.30400 0.015400 0.253000 -0.131000 -0.20300 0.9130 0.000207 0.044 0.3580 0.40000
IRE1alpha activates chaperones 9 8.07e-02 3.09e-01 0.2290 0.07300 0.044100 0.101000 -0.097000 0.16000 0.2220 0.205000 0.415 0.2490 0.86300
Unfolded Protein Response (UPR) 15 8.07e-02 3.09e-01 0.1890 0.06060 0.008810 0.141000 -0.097000 0.05110 0.2220 0.205000 0.415 0.2490 0.86300
XBP1(S) activates chaperone genes 9 8.07e-02 3.09e-01 0.2290 0.07300 0.044100 0.101000 -0.097000 0.16000 0.2220 0.205000 0.415 0.2490 0.86300
Class A/1 (Rhodopsin-like receptors) 5 1.26e-01 3.42e-01 0.3050 0.20000 0.098100 -0.118000 -0.146000 0.09070 0.0890 0.979000 0.148 0.7950 0.65700
G alpha (i) signalling events 22 1.26e-01 3.42e-01 0.2890 -0.09680 0.079600 -0.090900 -0.081900 0.23000 0.0890 0.979000 0.148 0.7950 0.65700
GPCR downstream signalling 30 1.26e-01 3.42e-01 0.2980 -0.10900 0.041500 -0.101000 -0.011800 0.25400 0.0890 0.979000 0.148 0.7950 0.65700
GPCR ligand binding 11 1.26e-01 3.42e-01 0.3300 0.03010 0.098100 -0.152000 -0.073100 0.26400 0.0890 0.979000 0.148 0.7950 0.65700
Signaling by GPCR 31 1.26e-01 3.42e-01 0.2950 -0.10900 0.041500 -0.101000 -0.011800 0.25100 0.0890 0.979000 0.148 0.7950 0.65700
Cellular responses to external stimuli 112 2.32e-01 5.86e-01 0.2060 0.07990 0.097100 0.003180 -0.094400 -0.13400 0.1390 0.760000 0.163 0.5590 0.00453
Metabolism of proteins 292 2.42e-01 5.86e-01 0.1040 0.01310 0.062700 0.010500 -0.044000 -0.06900 0.4290 0.859000 0.868 0.3250 0.10200
Post-translational protein modification 153 4.00e-01 7.85e-01 0.0546 -0.03860 -0.012300 0.034800 -0.010200 0.00535 0.0544 0.485000 0.691 0.7560 0.07020
Post-translational protein phosphorylation 25 4.00e-01 7.85e-01 0.5160 -0.29600 0.140000 -0.058100 0.023800 0.39400 0.0544 0.485000 0.691 0.7560 0.07020
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 28 4.00e-01 7.85e-01 0.5310 -0.28700 0.140000 -0.070400 -0.007020 0.41900 0.0544 0.485000 0.691 0.7560 0.07020
Cellular Senescence 21 4.86e-01 7.85e-01 0.2270 0.07180 -0.073100 0.047500 -0.127000 -0.15000 0.2420 0.784000 0.884 0.7630 0.17200
Senescence-Associated Secretory Phenotype (SASP) 13 4.86e-01 7.85e-01 0.1750 -0.03060 -0.054500 0.011400 -0.137000 -0.08790 0.2420 0.784000 0.884 0.7630 0.17200
Signal Transduction 235 4.96e-01 7.85e-01 0.1350 -0.05540 -0.012500 0.002420 -0.020800 0.12100 0.8490 0.305000 0.135 0.3090 0.86000
Cellular responses to stress 111 5.59e-01 7.85e-01 0.2180 0.08660 0.096700 0.009190 -0.095300 -0.14600 0.2080 0.775000 0.430 0.6070 0.03960
NR1H2 and NR1H3-mediated signaling 6 6.04e-01 7.85e-01 0.2760 -0.17600 0.194000 0.035100 -0.044100 0.06340 0.1610 0.145000 0.574 0.0863 0.83900
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 5 6.04e-01 7.85e-01 0.3640 -0.22500 0.194000 0.035100 -0.044100 0.20300 0.1610 0.145000 0.574 0.0863 0.83900
SLC-mediated transmembrane transport 21 6.04e-01 7.85e-01 0.2440 -0.05370 0.194000 -0.109000 0.066400 0.05090 0.1610 0.145000 0.574 0.0863 0.83900
Signaling by Nuclear Receptors 46 6.04e-01 7.85e-01 0.0823 -0.02670 0.028000 0.010800 -0.036300 0.06190 0.1610 0.145000 0.574 0.0863 0.83900
Transport of small molecules 76 6.04e-01 7.85e-01 0.2070 -0.10300 0.130000 0.009180 0.023400 0.12200 0.1610 0.145000 0.574 0.0863 0.83900
Transport of vitamins, nucleosides, and related molecules 5 6.04e-01 7.85e-01 0.3450 -0.20100 0.194000 -0.098400 0.078400 -0.15900 0.1610 0.145000 0.574 0.0863 0.83900
Metabolism 251 6.57e-01 7.85e-01 0.1720 0.04760 0.070500 -0.000650 -0.031000 -0.14600 0.1050 0.941000 0.799 0.7010 0.17500
Metabolism of amino acids and derivatives 78 6.57e-01 7.85e-01 0.3210 0.10700 0.164000 -0.045900 -0.126000 -0.21600 0.1050 0.941000 0.799 0.7010 0.17500
Metabolism of polyamines 9 6.57e-01 7.85e-01 0.3170 0.17400 0.026300 0.061900 0.027700 -0.25500 0.1050 0.941000 0.799 0.7010 0.17500
Regulation of ornithine decarboxylase (ODC) 6 6.57e-01 7.85e-01 0.3570 0.23000 0.026300 0.147000 0.027700 -0.22600 0.1050 0.941000 0.799 0.7010 0.17500
Major pathway of rRNA processing in the nucleolus and cytosol 79 6.82e-01 7.85e-01 0.4230 0.19400 0.165000 -0.034500 -0.148000 -0.30100 0.2110 0.879000 0.319 0.6400 0.19300
Metabolism of RNA 161 6.82e-01 7.85e-01 0.3980 0.21200 0.065900 0.052300 -0.097200 -0.31100 0.2110 0.879000 0.319 0.6400 0.19300
rRNA processing 82 6.82e-01 7.85e-01 0.4200 0.20000 0.161000 -0.030400 -0.137000 -0.30100 0.2110 0.879000 0.319 0.6400 0.19300
rRNA processing in the nucleus and cytosol 82 6.82e-01 7.85e-01 0.4200 0.20000 0.161000 -0.030400 -0.137000 -0.30100 0.2110 0.879000 0.319 0.6400 0.19300
Cellular response to heat stress 18 8.10e-01 8.49e-01 0.2550 0.18000 0.015300 0.081500 -0.061600 -0.14900 0.5990 0.908000 0.213 0.6910 0.19000
HSF1-dependent transactivation 8 8.10e-01 8.49e-01 0.2170 0.13000 -0.001860 0.045200 -0.098100 -0.13700 0.5990 0.908000 0.213 0.6910 0.19000
Cytokine Signaling in Immune system 97 8.49e-01 8.49e-01 0.1760 -0.09360 0.007000 0.024100 -0.067000 0.13000 0.5380 0.920000 0.263 0.8160 0.17000
Immune System 228 8.49e-01 8.49e-01 0.1750 -0.10500 0.005730 -0.002130 -0.015000 0.13900 0.5380 0.920000 0.263 0.8160 0.17000
Interferon Signaling 24 8.49e-01 8.49e-01 0.2860 -0.01620 0.074900 -0.126000 -0.109000 0.22000 0.5380 0.920000 0.263 0.8160 0.17000
Interferon gamma signaling 14 8.49e-01 8.49e-01 0.4630 -0.10000 0.086700 -0.147000 -0.007240 0.41900 0.5380 0.920000 0.263 0.8160 0.17000
ABC transporter disorders 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
ABC-family proteins mediated transport 10 NA NA 0.1510 -0.00262 -0.019700 0.090800 -0.039500 -0.11300 NA NA NA NA NA
ADORA2B mediated anti-inflammatory cytokines production 5 NA NA 0.6050 -0.25200 NaN -0.220000 0.073100 0.49900 NA NA NA NA NA
APC-Cdc20 mediated degradation of Nek2A 8 NA NA 0.6430 0.27000 -0.161000 0.088200 -0.207000 -0.51400 NA NA NA NA NA
APC/C-mediated degradation of cell cycle proteins 20 NA NA 0.4410 0.15600 -0.137000 0.153000 -0.039500 -0.35500 NA NA NA NA NA
APC/C:Cdc20 mediated degradation of Cyclin B 8 NA NA 0.5490 0.20500 -0.154000 0.112000 -0.207000 -0.42400 NA NA NA NA NA
APC/C:Cdc20 mediated degradation of Securin 12 NA NA 0.4130 0.12400 -0.138000 0.142000 -0.039500 -0.33900 NA NA NA NA NA
APC/C:Cdc20 mediated degradation of mitotic proteins 17 NA NA 0.4880 0.23700 -0.146000 0.143000 -0.039500 -0.37200 NA NA NA NA NA
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 14 NA NA 0.4130 0.16300 -0.125000 0.155000 -0.039500 -0.32100 NA NA NA NA NA
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 15 NA NA 0.4470 0.23700 -0.136000 0.105000 -0.039500 -0.33500 NA NA NA NA NA
AUF1 (hnRNP D0) binds and destabilizes mRNA 11 NA NA 0.2790 0.13500 -0.056600 0.033400 -0.039500 -0.23100 NA NA NA NA NA
AURKA Activation by TPX2 13 NA NA 0.3650 0.14700 -0.103000 0.166000 -0.110000 -0.24800 NA NA NA NA NA
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 6 NA NA 0.1700 0.12700 0.060400 -0.071200 NaN 0.06440 NA NA NA NA NA
Aberrant regulation of mitotic cell cycle due to RB1 defects 8 NA NA 0.2300 0.14200 -0.096500 0.010300 NaN -0.15300 NA NA NA NA NA
Abortive elongation of HIV-1 transcript in the absence of Tat 5 NA NA 0.2560 0.07050 0.077500 -0.184000 0.061700 -0.13000 NA NA NA NA NA
Activated NOTCH1 Transmits Signal to the Nucleus 6 NA NA 0.3610 -0.22800 NaN -0.188000 -0.207000 0.00219 NA NA NA NA NA
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 18 NA NA 0.4920 0.24300 -0.144000 0.154000 -0.039500 -0.37000 NA NA NA NA NA
Activation of ATR in response to replication stress 12 NA NA 0.5580 0.38100 -0.092900 0.093100 NaN -0.38600 NA NA NA NA NA
Activation of BH3-only proteins 5 NA NA 0.2500 0.01180 NaN 0.245000 -0.008560 -0.04380 NA NA NA NA NA
Activation of HOX genes during differentiation 10 NA NA 0.1060 0.01770 0.001980 0.046700 -0.072400 -0.05850 NA NA NA NA NA
Activation of Matrix Metalloproteinases 5 NA NA 0.6690 -0.37500 0.162000 -0.063800 -0.194000 0.48900 NA NA NA NA NA
Activation of NF-kappaB in B cells 9 NA NA 0.2850 -0.22800 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Activation of NMDA receptors and postsynaptic events 5 NA NA 0.2500 -0.16100 0.019700 -0.094500 NaN 0.16400 NA NA NA NA NA
Activation of anterior HOX genes in hindbrain development during early embryogenesis 10 NA NA 0.1060 0.01770 0.001980 0.046700 -0.072400 -0.05850 NA NA NA NA NA
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 27 NA NA 0.4030 0.13300 0.159000 0.086600 -0.127000 -0.30900 NA NA NA NA NA
Activation of the pre-replicative complex 13 NA NA 0.5370 0.36000 -0.097200 0.093100 NaN -0.37600 NA NA NA NA NA
Adaptive Immune System 72 NA NA 0.2940 -0.17800 -0.056900 -0.018200 0.037700 0.22300 NA NA NA NA NA
Adherens junctions interactions 5 NA NA 0.4570 -0.24200 NaN NaN NaN 0.38800 NA NA NA NA NA
Aggrephagy 7 NA NA 0.3610 0.04720 -0.063000 -0.188000 -0.207000 -0.21500 NA NA NA NA NA
Amino acid transport across the plasma membrane 6 NA NA 0.3310 0.32700 NaN NaN NaN 0.05390 NA NA NA NA NA
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 25 NA NA 0.4690 0.21400 -0.111000 0.184000 -0.025000 -0.35700 NA NA NA NA NA
Amplification of signal from the kinetochores 25 NA NA 0.4690 0.21400 -0.111000 0.184000 -0.025000 -0.35700 NA NA NA NA NA
Amyloid fiber formation 15 NA NA 0.4510 -0.31100 0.180000 -0.165000 -0.031100 0.21500 NA NA NA NA NA
Anchoring of the basal body to the plasma membrane 11 NA NA 0.2860 0.14700 -0.083300 0.099300 -0.093300 -0.18700 NA NA NA NA NA
Anti-inflammatory response favouring Leishmania parasite infection 9 NA NA 0.5120 -0.27800 NaN -0.158000 0.073100 0.39300 NA NA NA NA NA
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 7 NA NA 0.4950 -0.15400 NaN -0.214000 0.015800 0.41900 NA NA NA NA NA
Antigen processing-Cross presentation 19 NA NA 0.3230 -0.17200 -0.019700 -0.112000 0.026000 0.24800 NA NA NA NA NA
Antigen processing: Ubiquitination & Proteasome degradation 24 NA NA 0.1700 -0.05720 -0.128000 0.087400 -0.039500 -0.01400 NA NA NA NA NA
Antiviral mechanism by IFN-stimulated genes 10 NA NA 0.2730 0.09540 0.021100 -0.078200 -0.207000 -0.12500 NA NA NA NA NA
Apoptosis 26 NA NA 0.2130 -0.01000 -0.057300 0.148000 -0.061700 -0.12800 NA NA NA NA NA
Apoptotic cleavage of cellular proteins 8 NA NA 0.4090 -0.31800 -0.045800 0.051900 -0.120000 0.21600 NA NA NA NA NA
Apoptotic execution phase 11 NA NA 0.2560 -0.13200 -0.084500 0.163000 -0.120000 -0.01390 NA NA NA NA NA
Aquaporin-mediated transport 5 NA NA 0.4840 -0.26700 NaN NaN -0.025000 0.40300 NA NA NA NA NA
Arachidonic acid metabolism 6 NA NA 0.3330 -0.05650 -0.035600 -0.056500 NaN 0.32100 NA NA NA NA NA
Asparagine N-linked glycosylation 21 NA NA 0.2290 -0.18900 NaN -0.011000 -0.020200 0.12700 NA NA NA NA NA
Assembly Of The HIV Virion 6 NA NA 0.4850 -0.46000 NaN -0.068500 -0.060600 0.12200 NA NA NA NA NA
Assembly of collagen fibrils and other multimeric structures 13 NA NA 0.4330 -0.22100 0.093200 -0.114000 -0.081000 0.33300 NA NA NA NA NA
Assembly of the pre-replicative complex 16 NA NA 0.4590 0.34400 -0.092400 0.061100 -0.039500 -0.28100 NA NA NA NA NA
Association of TriC/CCT with target proteins during biosynthesis 10 NA NA 0.3730 0.25600 0.036900 0.089500 -0.143000 -0.20900 NA NA NA NA NA
Asymmetric localization of PCP proteins 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Attenuation phase 6 NA NA 0.4820 0.20200 -0.024500 0.125000 -0.121000 -0.40100 NA NA NA NA NA
Autodegradation of Cdh1 by Cdh1:APC/C 10 NA NA 0.3510 0.08530 -0.123000 0.088200 -0.039500 -0.30200 NA NA NA NA NA
Autodegradation of the E3 ubiquitin ligase COP1 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Autophagy 19 NA NA 0.2160 -0.05700 0.041000 -0.003300 -0.109000 -0.17200 NA NA NA NA NA
Axon guidance 120 NA NA 0.2140 -0.06270 0.160000 -0.095000 -0.064200 0.05700 NA NA NA NA NA
BBSome-mediated cargo-targeting to cilium 7 NA NA 0.4090 0.30700 0.018400 0.130000 -0.173000 -0.16100 NA NA NA NA NA
Base Excision Repair 10 NA NA 0.4090 0.28400 -0.097500 0.018900 NaN -0.27600 NA NA NA NA NA
Basigin interactions 9 NA NA 0.4070 -0.15100 0.109000 -0.036700 0.169000 0.31700 NA NA NA NA NA
Beta-catenin independent WNT signaling 21 NA NA 0.1210 0.08120 0.063000 -0.058100 -0.025500 -0.00285 NA NA NA NA NA
Binding and Uptake of Ligands by Scavenger Receptors 10 NA NA 0.3360 -0.18300 0.055900 -0.047200 NaN 0.27200 NA NA NA NA NA
Biological oxidations 14 NA NA 0.2420 0.03690 -0.165000 0.116000 -0.102000 -0.07950 NA NA NA NA NA
Budding and maturation of HIV virion 6 NA NA 0.4650 -0.44700 NaN -0.068500 -0.060600 0.08980 NA NA NA NA NA
C-type lectin receptors (CLRs) 15 NA NA 0.2800 -0.27000 0.063900 -0.002640 0.037400 -0.00610 NA NA NA NA NA
CDK-mediated phosphorylation and removal of Cdc6 11 NA NA 0.3970 0.17900 -0.132000 0.072800 -0.039500 -0.31800 NA NA NA NA NA
CDT1 association with the CDC6:ORC:origin complex 11 NA NA 0.3690 0.28300 -0.097400 0.043400 -0.039500 -0.20800 NA NA NA NA NA
CHL1 interactions 5 NA NA 0.4960 -0.15800 0.164000 -0.077800 -0.048400 0.43100 NA NA NA NA NA
CLEC7A (Dectin-1) signaling 13 NA NA 0.2860 -0.27000 0.063900 -0.002640 -0.039500 -0.05740 NA NA NA NA NA
COPI-dependent Golgi-to-ER retrograde traffic 13 NA NA 0.2060 0.04380 -0.072300 0.095300 0.037100 -0.15700 NA NA NA NA NA
COPI-mediated anterograde transport 9 NA NA 0.1960 -0.14400 NaN -0.049900 0.041400 0.11700 NA NA NA NA NA
Ca2+ pathway 6 NA NA 0.2440 0.00657 0.104000 -0.094500 -0.084900 0.18000 NA NA NA NA NA
Cap-dependent Translation Initiation 58 NA NA 0.3920 0.13800 0.176000 -0.065400 -0.157000 -0.27300 NA NA NA NA NA
Carboxyterminal post-translational modifications of tubulin 8 NA NA 0.5010 0.29700 -0.045100 0.182000 0.018500 -0.35700 NA NA NA NA NA
Cardiac conduction 10 NA NA 0.4380 -0.22400 0.152000 -0.063100 0.090700 0.32600 NA NA NA NA NA
Cargo recognition for clathrin-mediated endocytosis 13 NA NA 0.3090 -0.24800 NaN -0.092200 0.005550 0.15800 NA NA NA NA NA
Cargo trafficking to the periciliary membrane 8 NA NA 0.3900 0.30700 0.018400 0.130000 -0.122000 -0.16100 NA NA NA NA NA
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 15 NA NA 0.4470 0.23700 -0.136000 0.105000 -0.039500 -0.33500 NA NA NA NA NA
Cell Cycle 137 NA NA 0.4520 0.20500 -0.123000 0.159000 -0.040400 -0.34700 NA NA NA NA NA
Cell Cycle Checkpoints 59 NA NA 0.4780 0.22800 -0.123000 0.166000 0.001060 -0.36600 NA NA NA NA NA
Cell Cycle, Mitotic 115 NA NA 0.4660 0.22500 -0.123000 0.161000 -0.068200 -0.34800 NA NA NA NA NA
Cell death signalling via NRAGE, NRIF and NADE 11 NA NA 0.3240 -0.25700 -0.110000 -0.109000 -0.059300 0.10800 NA NA NA NA NA
Cell junction organization 10 NA NA 0.5100 -0.27100 NaN -0.013200 -0.211000 0.37700 NA NA NA NA NA
Cell surface interactions at the vascular wall 22 NA NA 0.4010 -0.15700 0.109000 -0.042600 -0.016900 0.34900 NA NA NA NA NA
Cell-Cell communication 13 NA NA 0.4970 -0.24200 NaN -0.002640 -0.211000 0.38000 NA NA NA NA NA
Cell-cell junction organization 5 NA NA 0.4570 -0.24200 NaN NaN NaN 0.38800 NA NA NA NA NA
Cellular response to hypoxia 10 NA NA 0.0657 -0.00262 -0.019700 0.043400 -0.039500 0.02190 NA NA NA NA NA
Centrosome maturation 12 NA NA 0.3190 0.15900 -0.080500 0.111000 -0.130000 -0.20100 NA NA NA NA NA
Chaperone Mediated Autophagy 8 NA NA 0.4230 0.17400 0.069800 0.027600 -0.174000 -0.33600 NA NA NA NA NA
Chaperonin-mediated protein folding 22 NA NA 0.2800 0.19100 -0.013600 0.127000 -0.024200 -0.15900 NA NA NA NA NA
Cholesterol biosynthesis 5 NA NA 0.3450 0.29100 -0.051200 0.124000 -0.097400 -0.08490 NA NA NA NA NA
Chondroitin sulfate/dermatan sulfate metabolism 5 NA NA 0.2880 -0.25800 NaN -0.026800 0.051100 0.11300 NA NA NA NA NA
Chromatin modifying enzymes 15 NA NA 0.3030 0.11100 -0.073500 0.138000 -0.196000 -0.12800 NA NA NA NA NA
Chromatin organization 15 NA NA 0.3030 0.11100 -0.073500 0.138000 -0.196000 -0.12800 NA NA NA NA NA
Chromosome Maintenance 26 NA NA 0.4100 0.20300 -0.084300 0.117000 0.026900 -0.32400 NA NA NA NA NA
Cilium Assembly 21 NA NA 0.2580 0.12200 -0.066500 0.115000 -0.126000 -0.13400 NA NA NA NA NA
Circadian Clock 10 NA NA 0.2520 -0.07990 NaN 0.038000 -0.211000 0.10600 NA NA NA NA NA
Class B/2 (Secretin family receptors) 6 NA NA 0.5530 -0.25200 NaN -0.220000 0.073100 0.43400 NA NA NA NA NA
Class I MHC mediated antigen processing & presentation 35 NA NA 0.2270 -0.11200 -0.128000 -0.013700 0.026000 0.14700 NA NA NA NA NA
Clathrin-mediated endocytosis 16 NA NA 0.2530 -0.21500 NaN -0.092200 0.005550 0.09780 NA NA NA NA NA
Collagen biosynthesis and modifying enzymes 12 NA NA 0.3040 -0.19800 0.128000 -0.033400 -0.007040 0.18900 NA NA NA NA NA
Collagen chain trimerization 9 NA NA 0.3880 -0.20300 0.144000 -0.087900 -0.081000 0.27200 NA NA NA NA NA
Collagen degradation 9 NA NA 0.4940 -0.28200 0.093200 -0.063700 -0.194000 0.33800 NA NA NA NA NA
Collagen formation 18 NA NA 0.3820 -0.21900 0.117000 -0.073000 -0.007040 0.28100 NA NA NA NA NA
Complex I biogenesis 11 NA NA 0.2780 -0.06170 0.014400 -0.061700 0.050800 -0.25900 NA NA NA NA NA
Condensation of Prometaphase Chromosomes 7 NA NA 0.4020 0.20100 -0.148000 0.178000 NaN -0.26000 NA NA NA NA NA
Condensation of Prophase Chromosomes 7 NA NA 0.4420 0.25300 -0.112000 0.181000 -0.116000 -0.26900 NA NA NA NA NA
Constitutive Signaling by Aberrant PI3K in Cancer 8 NA NA 0.3110 -0.27300 NaN 0.018400 NaN 0.14800 NA NA NA NA NA
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 5 NA NA 0.4610 0.32100 -0.063000 -0.188000 -0.207000 -0.16600 NA NA NA NA NA
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 10 NA NA 0.2250 -0.07270 0.085400 0.059300 -0.185000 -0.01530 NA NA NA NA NA
Constitutive Signaling by NOTCH1 PEST Domain Mutants 10 NA NA 0.2250 -0.07270 0.085400 0.059300 -0.185000 -0.01530 NA NA NA NA NA
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 10 NA NA 0.2040 0.00853 0.018400 0.145000 -0.087600 -0.11200 NA NA NA NA NA
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 18 NA NA 0.3260 0.19500 -0.025100 0.170000 -0.022200 -0.19600 NA NA NA NA NA
Costimulation by the CD28 family 6 NA NA 0.1740 NaN NaN 0.018400 NaN 0.17300 NA NA NA NA NA
Cristae formation 11 NA NA 0.5350 -0.47500 NaN -0.021000 0.111000 -0.21900 NA NA NA NA NA
Cross-presentation of soluble exogenous antigens (endosomes) 6 NA NA 0.3150 -0.00262 -0.019700 0.274000 0.129000 0.08470 NA NA NA NA NA
Cyclin A/B1/B2 associated events during G2/M transition 7 NA NA 0.4760 0.29700 -0.146000 0.193000 NaN -0.28200 NA NA NA NA NA
Cyclin A:Cdk2-associated events at S phase entry 15 NA NA 0.3320 0.16600 -0.072900 0.058300 -0.072600 -0.26200 NA NA NA NA NA
Cyclin D associated events in G1 14 NA NA 0.2270 -0.05610 -0.003080 -0.033600 -0.207000 -0.06410 NA NA NA NA NA
Cyclin E associated events during G1/S transition 15 NA NA 0.3320 0.16600 -0.072900 0.058300 -0.072600 -0.26200 NA NA NA NA NA
Cytosolic sensors of pathogen-associated DNA 14 NA NA 0.2640 0.12400 0.048900 -0.013500 -0.112000 -0.19800 NA NA NA NA NA
DAP12 interactions 8 NA NA 0.4010 -0.12500 NaN -0.264000 0.044600 0.27100 NA NA NA NA NA
DAP12 signaling 6 NA NA 0.3840 -0.09960 NaN -0.282000 0.044600 0.23700 NA NA NA NA NA
DDX58/IFIH1-mediated induction of interferon-alpha/beta 6 NA NA 0.6100 -0.26500 -0.003950 0.028100 0.001980 -0.54900 NA NA NA NA NA
DNA Damage Bypass 10 NA NA 0.4680 0.24800 -0.092600 -0.005920 -0.207000 -0.32500 NA NA NA NA NA
DNA Damage Recognition in GG-NER 9 NA NA 0.4160 0.23700 -0.148000 0.041700 -0.064900 -0.29800 NA NA NA NA NA
DNA Double Strand Break Response 9 NA NA 0.3530 0.14200 0.036900 -0.074300 -0.207000 -0.23300 NA NA NA NA NA
DNA Double-Strand Break Repair 22 NA NA 0.4140 0.23700 -0.056300 0.058500 -0.207000 -0.25600 NA NA NA NA NA
DNA Repair 39 NA NA 0.3470 0.22100 -0.070400 0.039600 -0.006440 -0.25500 NA NA NA NA NA
DNA Replication 30 NA NA 0.4760 0.28500 -0.108000 0.081200 -0.039500 -0.35400 NA NA NA NA NA
DNA Replication Pre-Initiation 21 NA NA 0.4640 0.32700 -0.089800 0.073600 -0.039500 -0.30500 NA NA NA NA NA
DNA strand elongation 12 NA NA 0.5390 0.36500 -0.092300 0.136000 NaN -0.36200 NA NA NA NA NA
Deactivation of the beta-catenin transactivating complex 8 NA NA 0.3780 -0.26900 0.122000 -0.188000 -0.060300 0.12900 NA NA NA NA NA
Deadenylation-dependent mRNA decay 11 NA NA 0.4070 0.19600 -0.042800 0.145000 NaN -0.32300 NA NA NA NA NA
Death Receptor Signalling 14 NA NA 0.3310 -0.27200 -0.110000 -0.033100 -0.059300 0.13800 NA NA NA NA NA
Dectin-1 mediated noncanonical NF-kB signaling 9 NA NA 0.2850 -0.22800 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Defective CFTR causes cystic fibrosis 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 6 NA NA 0.1700 0.12700 0.060400 -0.071200 NaN 0.06440 NA NA NA NA NA
Degradation of AXIN 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Degradation of DVL 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Degradation of GLI1 by the proteasome 9 NA NA 0.2850 -0.22800 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Degradation of GLI2 by the proteasome 10 NA NA 0.2390 -0.22800 -0.019700 0.043400 -0.039500 -0.03550 NA NA NA NA NA
Degradation of beta-catenin by the destruction complex 14 NA NA 0.1130 -0.00263 0.063000 0.043400 -0.072600 -0.03970 NA NA NA NA NA
Degradation of the extracellular matrix 18 NA NA 0.5500 -0.32500 0.143000 -0.079200 -0.000658 0.41300 NA NA NA NA NA
Depolymerisation of the Nuclear Lamina 5 NA NA 0.5100 0.06440 -0.101000 0.227000 -0.080100 -0.43400 NA NA NA NA NA
Deposition of new CENPA-containing nucleosomes at the centromere 13 NA NA 0.4790 0.12300 -0.109000 0.203000 -0.049900 -0.39800 NA NA NA NA NA
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 6 NA NA 0.4040 -0.12700 0.000881 0.218000 -0.080100 -0.30600 NA NA NA NA NA
Detoxification of Reactive Oxygen Species 10 NA NA 0.2720 0.03940 0.060600 -0.043500 0.021600 -0.25800 NA NA NA NA NA
Deubiquitination 28 NA NA 0.2580 0.16000 -0.057800 0.070100 -0.040400 -0.17600 NA NA NA NA NA
Disease 207 NA NA 0.1150 0.00171 0.071900 0.023000 -0.034300 -0.07950 NA NA NA NA NA
Diseases associated with glycosaminoglycan metabolism 5 NA NA 0.3490 -0.31800 NaN -0.021500 0.077800 -0.11900 NA NA NA NA NA
Diseases of carbohydrate metabolism 6 NA NA 0.5050 0.22900 NaN -0.188000 -0.207000 -0.35200 NA NA NA NA NA
Diseases of glycosylation 10 NA NA 0.2950 -0.27800 NaN -0.021500 0.096700 0.00473 NA NA NA NA NA
Diseases of metabolism 19 NA NA 0.1830 -0.11200 NaN -0.028100 0.058300 -0.12900 NA NA NA NA NA
Diseases of mitotic cell cycle 8 NA NA 0.2300 0.14200 -0.096500 0.010300 NaN -0.15300 NA NA NA NA NA
Diseases of programmed cell death 7 NA NA 0.4650 -0.00580 0.000881 0.218000 -0.084900 -0.40200 NA NA NA NA NA
Diseases of signal transduction by growth factor receptors and second messengers 48 NA NA 0.1490 -0.07450 0.038800 0.085000 -0.084800 0.02630 NA NA NA NA NA
Disorders of transmembrane transporters 14 NA NA 0.1190 0.07070 -0.019700 0.058000 0.026000 -0.06930 NA NA NA NA NA
Downregulation of ERBB2 signaling 5 NA NA 0.6460 0.32100 -0.063000 -0.188000 -0.207000 -0.48100 NA NA NA NA NA
Downregulation of SMAD2/3:SMAD4 transcriptional activity 5 NA NA 0.5480 0.17500 -0.148000 0.046100 -0.207000 -0.45000 NA NA NA NA NA
Downregulation of TGF-beta receptor signaling 10 NA NA 0.2410 -0.00876 0.015800 -0.026800 -0.139000 -0.19400 NA NA NA NA NA
Downstream TCR signaling 12 NA NA 0.2480 -0.22800 -0.019700 0.043400 -0.039500 -0.07260 NA NA NA NA NA
Downstream signaling events of B Cell Receptor (BCR) 13 NA NA 0.2830 -0.27000 0.063900 0.042900 -0.008370 -0.02890 NA NA NA NA NA
Dual Incision in GG-NER 9 NA NA 0.4890 0.26900 -0.097500 0.012300 -0.207000 -0.33800 NA NA NA NA NA
Dual incision in TC-NER 13 NA NA 0.2700 0.14700 -0.040400 -0.065500 0.003960 -0.21300 NA NA NA NA NA
E2F mediated regulation of DNA replication 6 NA NA 0.5460 0.37700 -0.153000 0.266000 NaN -0.24900 NA NA NA NA NA
E3 ubiquitin ligases ubiquitinate target proteins 8 NA NA 0.2430 -0.01930 -0.105000 -0.182000 -0.115000 -0.03450 NA NA NA NA NA
ECM proteoglycans 10 NA NA 0.3310 -0.21900 0.143000 -0.014600 0.007620 0.20100 NA NA NA NA NA
EGR2 and SOX10-mediated initiation of Schwann cell myelination 6 NA NA 0.3450 -0.04330 NaN 0.076900 0.045300 -0.33000 NA NA NA NA NA
EML4 and NUDC in mitotic spindle formation 25 NA NA 0.4690 0.21400 -0.111000 0.184000 -0.025000 -0.35700 NA NA NA NA NA
EPH-Ephrin signaling 17 NA NA 0.5050 -0.33300 NaN -0.168000 -0.036200 0.33800 NA NA NA NA NA
EPH-ephrin mediated repulsion of cells 9 NA NA 0.4750 -0.27900 NaN -0.135000 -0.036200 0.35800 NA NA NA NA NA
EPHB-mediated forward signaling 6 NA NA 0.3560 -0.35000 NaN NaN NaN 0.06360 NA NA NA NA NA
ER to Golgi Anterograde Transport 12 NA NA 0.1730 -0.13500 NaN -0.049900 -0.005630 0.09610 NA NA NA NA NA
ER-Phagosome pathway 16 NA NA 0.2800 -0.17200 -0.019700 -0.112000 0.026000 0.18800 NA NA NA NA NA
ESR-mediated signaling 34 NA NA 0.0714 0.00933 0.012200 0.004490 -0.067300 -0.01740 NA NA NA NA NA
Early Phase of HIV Life Cycle 6 NA NA 0.5940 0.27500 0.014500 0.166000 -0.129000 -0.48300 NA NA NA NA NA
Elastic fibre formation 7 NA NA 0.5460 -0.15300 NaN -0.106000 -0.159000 0.48800 NA NA NA NA NA
Endosomal Sorting Complex Required For Transport (ESCRT) 5 NA NA 0.4980 -0.44700 NaN -0.192000 -0.060600 0.08980 NA NA NA NA NA
Endosomal/Vacuolar pathway 6 NA NA 0.4800 -0.15400 NaN -0.214000 0.044600 0.39800 NA NA NA NA NA
Estrogen-dependent gene expression 24 NA NA 0.2000 0.09720 0.002160 0.052800 -0.043400 -0.16100 NA NA NA NA NA
Eukaryotic Translation Elongation 52 NA NA 0.4390 0.18700 0.186000 -0.131000 -0.148000 -0.28900 NA NA NA NA NA
Eukaryotic Translation Initiation 58 NA NA 0.3920 0.13800 0.176000 -0.065400 -0.157000 -0.27300 NA NA NA NA NA
Eukaryotic Translation Termination 50 NA NA 0.4210 0.16800 0.184000 -0.131000 -0.156000 -0.27200 NA NA NA NA NA
Extension of Telomeres 10 NA NA 0.4570 0.31800 -0.066200 0.071600 0.068300 -0.30600 NA NA NA NA NA
Extra-nuclear estrogen signaling 13 NA NA 0.2920 -0.14600 0.023100 -0.030100 -0.113000 0.22300 NA NA NA NA NA
Extracellular matrix organization 47 NA NA 0.4620 -0.23100 0.144000 -0.076300 -0.039400 0.36300 NA NA NA NA NA
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 10 NA NA 0.2930 -0.22800 -0.034900 0.076000 -0.039500 -0.15900 NA NA NA NA NA
FCERI mediated MAPK activation 5 NA NA 0.1290 -0.06680 NaN NaN NaN 0.11100 NA NA NA NA NA
FCERI mediated NF-kB activation 10 NA NA 0.3100 -0.22800 -0.019700 0.043400 -0.039500 -0.20100 NA NA NA NA NA
FCGR3A-mediated phagocytosis 8 NA NA 0.4290 -0.35000 NaN -0.235000 0.052500 0.06360 NA NA NA NA NA
FGFR2 alternative splicing 9 NA NA 0.2630 0.12000 0.077500 -0.184000 0.061700 -0.10500 NA NA NA NA NA
FGFR2 mutant receptor activation 5 NA NA 0.2560 0.07050 0.077500 -0.184000 0.061700 -0.13000 NA NA NA NA NA
FLT3 Signaling 31 NA NA 0.2290 -0.16200 -0.019700 0.046000 -0.058300 0.14300 NA NA NA NA NA
FOXO-mediated transcription 10 NA NA 0.3370 -0.27500 0.146000 0.043600 0.024400 0.11900 NA NA NA NA NA
Factors involved in megakaryocyte development and platelet production 14 NA NA 0.2380 0.15600 -0.068600 0.093800 0.025500 -0.13500 NA NA NA NA NA
Fanconi Anemia Pathway 8 NA NA 0.5390 0.26400 -0.115000 0.032500 -0.207000 -0.40400 NA NA NA NA NA
Fatty acid metabolism 14 NA NA 0.1480 -0.04470 -0.007490 -0.056500 0.016300 0.12800 NA NA NA NA NA
Fc epsilon receptor (FCERI) signaling 18 NA NA 0.2350 -0.22000 0.063900 -0.002640 -0.039500 0.03320 NA NA NA NA NA
Fcgamma receptor (FCGR) dependent phagocytosis 12 NA NA 0.1660 -0.14200 -0.063000 -0.045700 -0.030800 0.01890 NA NA NA NA NA
Folding of actin by CCT/TriC 8 NA NA 0.2980 0.09310 0.018400 0.145000 -0.143000 -0.19600 NA NA NA NA NA
Formation of ATP by chemiosmotic coupling 9 NA NA 0.5520 -0.47500 NaN -0.177000 0.111000 -0.19000 NA NA NA NA NA
Formation of HIV elongation complex in the absence of HIV Tat 8 NA NA 0.2410 0.11500 0.023100 -0.184000 0.061700 -0.08340 NA NA NA NA NA
Formation of HIV-1 elongation complex containing HIV-1 Tat 8 NA NA 0.2410 0.11500 0.023100 -0.184000 0.061700 -0.08340 NA NA NA NA NA
Formation of Incision Complex in GG-NER 8 NA NA 0.4310 0.19800 -0.119000 0.012300 -0.207000 -0.29900 NA NA NA NA NA
Formation of RNA Pol II elongation complex 8 NA NA 0.2410 0.11500 0.023100 -0.184000 0.061700 -0.08340 NA NA NA NA NA
Formation of TC-NER Pre-Incision Complex 10 NA NA 0.1720 0.07050 0.077500 -0.036000 -0.021800 -0.13000 NA NA NA NA NA
Formation of a pool of free 40S subunits 53 NA NA 0.4130 0.15400 0.176000 -0.097300 -0.157000 -0.28600 NA NA NA NA NA
Formation of the Early Elongation Complex 5 NA NA 0.2560 0.07050 0.077500 -0.184000 0.061700 -0.13000 NA NA NA NA NA
Formation of the HIV-1 Early Elongation Complex 5 NA NA 0.2560 0.07050 0.077500 -0.184000 0.061700 -0.13000 NA NA NA NA NA
Formation of the beta-catenin:TCF transactivating complex 7 NA NA 0.3650 0.31500 0.104000 NaN -0.138000 -0.06160 NA NA NA NA NA
Formation of the ternary complex, and subsequently, the 43S complex 24 NA NA 0.4000 0.15200 0.159000 0.086600 -0.127000 -0.29600 NA NA NA NA NA
Formation of tubulin folding intermediates by CCT/TriC 15 NA NA 0.4040 0.27700 -0.032500 0.153000 -0.022200 -0.24800 NA NA NA NA NA
G alpha (12/13) signalling events 6 NA NA 0.5010 -0.13800 -0.110000 -0.078200 0.014100 0.46200 NA NA NA NA NA
G alpha (q) signalling events 6 NA NA 0.3610 -0.06570 0.119000 -0.085300 0.027200 0.32200 NA NA NA NA NA
G alpha (s) signalling events 5 NA NA 0.6050 -0.25200 NaN -0.220000 0.073100 0.49900 NA NA NA NA NA
G0 and Early G1 7 NA NA 0.5350 0.34500 -0.091900 0.072300 -0.138000 -0.36600 NA NA NA NA NA
G1 Phase 14 NA NA 0.2270 -0.05610 -0.003080 -0.033600 -0.207000 -0.06410 NA NA NA NA NA
G1/S DNA Damage Checkpoints 11 NA NA 0.2930 0.13500 -0.086900 0.055500 -0.039500 -0.23500 NA NA NA NA NA
G1/S Transition 37 NA NA 0.4620 0.29300 -0.107000 0.099800 -0.072600 -0.31900 NA NA NA NA NA
G1/S-Specific Transcription 9 NA NA 0.5190 0.33200 -0.116000 0.144000 NaN -0.35300 NA NA NA NA NA
G2/M Checkpoints 29 NA NA 0.4450 0.23400 -0.106000 0.150000 0.018500 -0.33000 NA NA NA NA NA
G2/M DNA damage checkpoint 9 NA NA 0.3970 0.00685 -0.102000 0.230000 0.134000 -0.27700 NA NA NA NA NA
G2/M Transition 34 NA NA 0.3690 0.11600 -0.123000 0.169000 -0.089100 -0.26700 NA NA NA NA NA
GLI3 is processed to GLI3R by the proteasome 10 NA NA 0.2390 -0.22800 -0.019700 0.043400 -0.039500 -0.03550 NA NA NA NA NA
GTP hydrolysis and joining of the 60S ribosomal subunit 56 NA NA 0.3810 0.13800 0.176000 -0.065400 -0.157000 -0.25700 NA NA NA NA NA
Gap-filling DNA repair synthesis and ligation in GG-NER 8 NA NA 0.4430 0.22300 -0.079700 -0.005920 -0.207000 -0.31200 NA NA NA NA NA
Gap-filling DNA repair synthesis and ligation in TC-NER 13 NA NA 0.2700 0.14700 -0.040400 -0.065500 0.003960 -0.21300 NA NA NA NA NA
Gene Silencing by RNA 10 NA NA 0.3430 0.17400 0.007250 0.112000 -0.060300 -0.26700 NA NA NA NA NA
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 14 NA NA 0.4170 0.07700 -0.092800 0.200000 -0.098400 -0.33200 NA NA NA NA NA
Global Genome Nucleotide Excision Repair (GG-NER) 16 NA NA 0.3720 0.22000 -0.097500 0.075600 -0.064900 -0.26500 NA NA NA NA NA
Gluconeogenesis 6 NA NA 0.4380 0.26000 NaN 0.146000 NaN -0.32100 NA NA NA NA NA
Glucose metabolism 12 NA NA 0.3720 0.28900 0.021000 0.116000 NaN -0.20100 NA NA NA NA NA
Glutamate binding, activation of AMPA receptors and synaptic plasticity 6 NA NA 0.5750 0.14200 NaN 0.123000 0.151000 0.52200 NA NA NA NA NA
Glutathione conjugation 5 NA NA 0.3340 0.18900 NaN 0.085200 -0.193000 -0.17800 NA NA NA NA NA
Glycerophospholipid biosynthesis 7 NA NA 0.1290 -0.04540 NaN 0.053000 -0.053700 0.09390 NA NA NA NA NA
Glycogen metabolism 5 NA NA 0.4610 -0.35300 NaN -0.141000 -0.207000 0.15900 NA NA NA NA NA
Glycolysis 10 NA NA 0.3530 0.29400 0.021000 0.116000 NaN -0.15600 NA NA NA NA NA
Glycosaminoglycan metabolism 8 NA NA 0.3290 -0.27600 -0.155000 0.033100 0.077800 0.02300 NA NA NA NA NA
Golgi Cisternae Pericentriolar Stack Reorganization 5 NA NA 0.4840 0.13100 -0.143000 0.253000 NaN -0.36500 NA NA NA NA NA
Golgi-to-ER retrograde transport 15 NA NA 0.1670 -0.06270 -0.072300 0.095300 0.037100 -0.09170 NA NA NA NA NA
HCMV Early Events 9 NA NA 0.1870 0.02510 -0.109000 0.074600 -0.130000 -0.00702 NA NA NA NA NA
HCMV Infection 11 NA NA 0.1760 -0.09380 -0.109000 0.020400 -0.057700 0.08220 NA NA NA NA NA
HDR through Homologous Recombination (HRR) 9 NA NA 0.4220 0.22300 -0.073300 -0.005920 -0.207000 -0.28200 NA NA NA NA NA
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 15 NA NA 0.4210 0.23800 -0.090300 -0.000439 -0.207000 -0.26400 NA NA NA NA NA
HIV Infection 44 NA NA 0.1210 0.02790 -0.012900 0.058000 0.025500 -0.09810 NA NA NA NA NA
HIV Life Cycle 27 NA NA 0.2230 0.12100 -0.017600 0.069700 -0.045800 -0.16600 NA NA NA NA NA
HIV Transcription Elongation 8 NA NA 0.2410 0.11500 0.023100 -0.184000 0.061700 -0.08340 NA NA NA NA NA
HIV Transcription Initiation 6 NA NA 0.2330 0.07050 0.038200 -0.184000 0.043500 -0.11000 NA NA NA NA NA
HIV elongation arrest and recovery 8 NA NA 0.2410 0.11500 0.023100 -0.184000 0.061700 -0.08340 NA NA NA NA NA
HSF1 activation 7 NA NA 0.5540 0.26000 0.002890 0.138000 -0.157000 -0.44200 NA NA NA NA NA
HSP90 chaperone cycle for steroid hormone receptors (SHR) 9 NA NA 0.2830 0.06040 -0.053700 0.160000 -0.121000 -0.18200 NA NA NA NA NA
Hedgehog 'off' state 11 NA NA 0.3170 -0.30500 -0.019700 0.043400 -0.039500 0.05970 NA NA NA NA NA
Hedgehog 'on' state 9 NA NA 0.0714 -0.00262 -0.019700 0.043400 -0.039500 -0.03550 NA NA NA NA NA
Hedgehog ligand biogenesis 9 NA NA 0.0743 -0.00262 -0.019700 0.043400 -0.039500 -0.04100 NA NA NA NA NA
Hemostasis 81 NA NA 0.3560 -0.20400 0.054200 -0.072000 0.020800 0.27600 NA NA NA NA NA
Hh mutants abrogate ligand secretion 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Homology Directed Repair 17 NA NA 0.4560 0.27300 -0.099300 0.011900 -0.207000 -0.28300 NA NA NA NA NA
Host Interactions of HIV factors 30 NA NA 0.1630 0.04190 -0.052400 0.086700 0.012600 -0.12000 NA NA NA NA NA
ISG15 antiviral mechanism 10 NA NA 0.2730 0.09540 0.021100 -0.078200 -0.207000 -0.12500 NA NA NA NA NA
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 11 NA NA 0.5830 -0.21600 NaN -0.191000 0.044600 0.50500 NA NA NA NA NA
Inactivation of APC/C via direct inhibition of the APC/C complex 5 NA NA 0.6380 0.27000 -0.161000 0.157000 NaN -0.53300 NA NA NA NA NA
Infection with Mycobacterium tuberculosis 8 NA NA 0.2540 0.08920 0.033600 -0.032400 -0.081600 -0.21900 NA NA NA NA NA
Infectious disease 146 NA NA 0.1380 0.02460 0.087400 0.004260 -0.049600 -0.09070 NA NA NA NA NA
Influenza Infection 63 NA NA 0.3930 0.17400 0.146000 -0.069000 -0.135000 -0.28300 NA NA NA NA NA
Influenza Viral RNA Transcription and Replication 59 NA NA 0.4010 0.19000 0.156000 -0.101000 -0.131000 -0.27000 NA NA NA NA NA
Inhibition of DNA recombination at telomere 5 NA NA 0.2630 0.07050 0.077500 -0.184000 0.061700 -0.14400 NA NA NA NA NA
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 5 NA NA 0.6380 0.27000 -0.161000 0.157000 NaN -0.53300 NA NA NA NA NA
Initiation of Nuclear Envelope (NE) Reformation 8 NA NA 0.4630 0.11900 -0.089300 0.233000 -0.080100 -0.36200 NA NA NA NA NA
Innate Immune System 130 NA NA 0.1730 -0.11300 0.043800 -0.042800 0.020100 0.11500 NA NA NA NA NA
Integration of energy metabolism 10 NA NA 0.2220 -0.08260 NaN -0.015700 -0.122000 0.16500 NA NA NA NA NA
Integration of provirus 5 NA NA 0.5800 0.24100 0.014500 0.166000 -0.129000 -0.48300 NA NA NA NA NA
Integrin cell surface interactions 9 NA NA 0.5420 -0.20900 0.164000 -0.046000 -0.054600 0.46700 NA NA NA NA NA
Interactions of Rev with host cellular proteins 8 NA NA 0.6360 0.20800 -0.077700 0.198000 -0.108000 -0.55100 NA NA NA NA NA
Interactions of Vpr with host cellular proteins 6 NA NA 0.5570 0.22300 -0.032800 0.086600 0.013200 -0.50200 NA NA NA NA NA
Interconversion of nucleotide di- and triphosphates 12 NA NA 0.4620 0.22100 -0.085000 -0.053500 -0.052500 -0.39000 NA NA NA NA NA
Interferon alpha/beta signaling 8 NA NA 0.5490 -0.14000 0.168000 -0.119000 -0.209000 0.44200 NA NA NA NA NA
Interleukin-1 family signaling 14 NA NA 0.3320 -0.24400 -0.009250 0.067000 0.044500 -0.21000 NA NA NA NA NA
Interleukin-1 signaling 13 NA NA 0.3350 -0.24400 -0.009250 0.078900 0.044500 -0.21000 NA NA NA NA NA
Interleukin-12 family signaling 17 NA NA 0.2450 0.06190 -0.092800 0.158000 -0.098400 -0.11300 NA NA NA NA NA
Interleukin-12 signaling 15 NA NA 0.3180 0.06190 -0.092800 0.158000 -0.098400 -0.23200 NA NA NA NA NA
Interleukin-17 signaling 10 NA NA 0.3360 -0.22300 NaN -0.124000 -0.207000 0.07150 NA NA NA NA NA
Interleukin-3, Interleukin-5 and GM-CSF signaling 5 NA NA 0.5180 -0.23500 NaN -0.057200 0.134000 0.43800 NA NA NA NA NA
Interleukin-4 and Interleukin-13 signaling 22 NA NA 0.3230 -0.09610 0.021300 -0.058000 -0.133000 0.27100 NA NA NA NA NA
Interleukin-6 family signaling 5 NA NA 0.5720 -0.04460 NaN -0.057200 NaN 0.56700 NA NA NA NA NA
Intra-Golgi and retrograde Golgi-to-ER traffic 19 NA NA 0.1410 -0.09610 -0.032200 0.095300 0.022700 0.01160 NA NA NA NA NA
Intracellular signaling by second messengers 26 NA NA 0.1560 -0.13600 -0.024700 0.037400 -0.039500 0.04760 NA NA NA NA NA
Intrinsic Pathway for Apoptosis 7 NA NA 0.3960 0.11100 0.070900 0.215000 -0.035700 -0.30400 NA NA NA NA NA
Ion channel transport 17 NA NA 0.4160 -0.22200 0.152000 -0.074400 -0.000532 0.30800 NA NA NA NA NA
Ion homeostasis 8 NA NA 0.4780 -0.22400 0.152000 -0.063100 0.045400 0.38700 NA NA NA NA NA
Ion transport by P-type ATPases 9 NA NA 0.4740 -0.22400 0.152000 0.005270 0.045400 0.38700 NA NA NA NA NA
Iron uptake and transport 9 NA NA 0.2990 -0.23100 0.167000 -0.043100 -0.076200 0.02490 NA NA NA NA NA
Josephin domain DUBs 5 NA NA 0.5450 -0.17100 NaN -0.188000 -0.207000 -0.43500 NA NA NA NA NA
Kinesins 9 NA NA 0.3940 0.31800 -0.072300 0.095300 0.113000 -0.16400 NA NA NA NA NA
L13a-mediated translational silencing of Ceruloplasmin expression 56 NA NA 0.3920 0.14300 0.176000 -0.065400 -0.157000 -0.27100 NA NA NA NA NA
L1CAM interactions 20 NA NA 0.4040 -0.15900 0.164000 -0.084800 0.010400 0.32300 NA NA NA NA NA
Lagging Strand Synthesis 5 NA NA 0.4560 0.30200 -0.079700 0.176000 NaN -0.28100 NA NA NA NA NA
Laminin interactions 5 NA NA 0.5210 -0.20800 0.156000 -0.087400 0.010500 0.44300 NA NA NA NA NA
Late Phase of HIV Life Cycle 22 NA NA 0.1570 0.07790 -0.033500 0.046300 -0.028700 -0.12000 NA NA NA NA NA
Late endosomal microautophagy 7 NA NA 0.3550 -0.29000 NaN -0.192000 -0.060600 -0.04110 NA NA NA NA NA
Leishmania infection 20 NA NA 0.3200 -0.25600 NaN -0.077300 0.019500 0.17400 NA NA NA NA NA
Leishmania parasite growth and survival 9 NA NA 0.5120 -0.27800 NaN -0.158000 0.073100 0.39300 NA NA NA NA NA
Leishmania phagocytosis 8 NA NA 0.4290 -0.35000 NaN -0.235000 0.052500 0.06360 NA NA NA NA NA
Loss of Nlp from mitotic centrosomes 10 NA NA 0.3000 0.14700 -0.083300 0.099300 -0.130000 -0.18700 NA NA NA NA NA
Loss of proteins required for interphase microtubule organization from the centrosome 10 NA NA 0.3000 0.14700 -0.083300 0.099300 -0.130000 -0.18700 NA NA NA NA NA
Lysosome Vesicle Biogenesis 5 NA NA 0.3690 -0.26600 NaN -0.223000 0.108000 -0.06290 NA NA NA NA NA
M Phase 73 NA NA 0.4510 0.18700 -0.111000 0.175000 -0.055500 -0.35100 NA NA NA NA NA
MAP kinase activation 10 NA NA 0.3360 -0.22300 NaN -0.124000 -0.207000 0.07150 NA NA NA NA NA
MAPK family signaling cascades 38 NA NA 0.1720 -0.08050 0.032200 0.031400 -0.095300 0.11000 NA NA NA NA NA
MAPK targets/ Nuclear events mediated by MAP kinases 5 NA NA 0.2880 -0.10700 NaN -0.059000 NaN 0.26000 NA NA NA NA NA
MAPK1/MAPK3 signaling 33 NA NA 0.2120 -0.12500 -0.058000 0.046000 -0.058300 0.14300 NA NA NA NA NA
MAPK6/MAPK4 signaling 14 NA NA 0.1990 0.09780 0.032200 -0.004390 -0.104000 -0.13500 NA NA NA NA NA
MHC class II antigen presentation 20 NA NA 0.2540 -0.16900 -0.039100 -0.020500 0.024500 0.18300 NA NA NA NA NA
Macroautophagy 16 NA NA 0.2970 -0.00595 -0.040200 -0.030200 -0.207000 -0.20700 NA NA NA NA NA
Meiosis 10 NA NA 0.3470 0.15800 -0.069100 0.182000 -0.080100 -0.22600 NA NA NA NA NA
Meiotic recombination 5 NA NA 0.5470 0.45500 -0.109000 0.176000 NaN -0.22200 NA NA NA NA NA
Meiotic synapsis 6 NA NA 0.3030 0.00919 -0.037800 0.185000 -0.080100 -0.22300 NA NA NA NA NA
Membrane Trafficking 56 NA NA 0.2530 -0.22800 0.001330 -0.022800 0.025600 0.10400 NA NA NA NA NA
Metabolism of carbohydrates 30 NA NA 0.1790 0.08380 -0.037000 0.012900 -0.008890 -0.15300 NA NA NA NA NA
Metabolism of fat-soluble vitamins 7 NA NA 0.5370 -0.34500 0.099800 -0.087400 -0.003940 0.38900 NA NA NA NA NA
Metabolism of lipids 43 NA NA 0.1080 -0.06330 0.024100 0.062300 -0.049000 0.02830 NA NA NA NA NA
Metabolism of non-coding RNA 8 NA NA 0.6830 0.38300 -0.089800 0.132000 NaN -0.54200 NA NA NA NA NA
Metabolism of nucleotides 25 NA NA 0.4290 0.24800 -0.088700 -0.010300 -0.052500 -0.33400 NA NA NA NA NA
Metabolism of steroids 13 NA NA 0.2370 0.13400 -0.014500 0.119000 -0.066600 -0.13900 NA NA NA NA NA
Metabolism of vitamins and cofactors 27 NA NA 0.1230 -0.09610 -0.013700 0.004180 -0.044400 0.06140 NA NA NA NA NA
Metabolism of water-soluble vitamins and cofactors 17 NA NA 0.2040 0.08520 -0.077500 0.129000 -0.057700 -0.09250 NA NA NA NA NA
MicroRNA (miRNA) biogenesis 5 NA NA 0.2720 0.07900 0.077500 0.046000 -0.023000 -0.24400 NA NA NA NA NA
Mitochondrial biogenesis 18 NA NA 0.2230 -0.13500 0.007250 0.044700 0.070800 -0.15600 NA NA NA NA NA
Mitochondrial calcium ion transport 9 NA NA 0.4710 0.24700 NaN 0.127000 -0.051400 -0.37600 NA NA NA NA NA
Mitochondrial protein import 24 NA NA 0.4190 0.18700 0.014100 0.077700 0.045700 -0.36400 NA NA NA NA NA
Mitochondrial translation 26 NA NA 0.2740 0.15900 0.030200 -0.065900 0.015000 -0.21000 NA NA NA NA NA
Mitochondrial translation elongation 26 NA NA 0.2740 0.15900 0.030200 -0.065900 0.015000 -0.21000 NA NA NA NA NA
Mitochondrial translation initiation 25 NA NA 0.2690 0.14400 0.030200 -0.065900 0.015000 -0.21500 NA NA NA NA NA
Mitochondrial translation termination 25 NA NA 0.2690 0.14400 0.030200 -0.065900 0.015000 -0.21500 NA NA NA NA NA
Mitophagy 10 NA NA 0.3350 0.06650 -0.017100 -0.030200 -0.207000 -0.25300 NA NA NA NA NA
Mitotic Anaphase 57 NA NA 0.4640 0.18000 -0.108000 0.193000 -0.029800 -0.36500 NA NA NA NA NA
Mitotic G1 phase and G1/S transition 43 NA NA 0.3920 0.24500 -0.094200 0.066900 -0.072600 -0.27400 NA NA NA NA NA
Mitotic G2-G2/M phases 34 NA NA 0.3690 0.11600 -0.123000 0.169000 -0.089100 -0.26700 NA NA NA NA NA
Mitotic Metaphase and Anaphase 57 NA NA 0.4640 0.18000 -0.108000 0.193000 -0.029800 -0.36500 NA NA NA NA NA
Mitotic Prometaphase 42 NA NA 0.4510 0.20700 -0.115000 0.176000 -0.078200 -0.33200 NA NA NA NA NA
Mitotic Prophase 15 NA NA 0.4140 0.16300 -0.109000 0.187000 -0.098100 -0.29700 NA NA NA NA NA
Mitotic Spindle Checkpoint 27 NA NA 0.4850 0.21000 -0.119000 0.179000 -0.025000 -0.38000 NA NA NA NA NA
Molecules associated with elastic fibres 6 NA NA 0.6140 -0.15300 NaN -0.106000 -0.159000 0.56300 NA NA NA NA NA
Muscle contraction 21 NA NA 0.5140 -0.25600 0.118000 -0.133000 -0.027800 0.40800 NA NA NA NA NA
MyD88 cascade initiated on plasma membrane 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
MyD88 dependent cascade initiated on endosome 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
MyD88-independent TLR4 cascade 13 NA NA 0.2310 -0.23000 -0.003950 -0.000265 0.001980 -0.02060 NA NA NA NA NA
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
Myogenesis 5 NA NA 0.4190 -0.17600 NaN -0.059000 NaN 0.37600 NA NA NA NA NA
NCAM signaling for neurite out-growth 7 NA NA 0.4340 -0.26800 NaN -0.087900 -0.022300 0.32900 NA NA NA NA NA
NF-kB is activated and signals survival 5 NA NA 0.3890 -0.27000 NaN -0.188000 -0.207000 0.01970 NA NA NA NA NA
NGF-stimulated transcription 8 NA NA 0.4650 -0.20500 0.080400 -0.255000 -0.021100 0.32000 NA NA NA NA NA
NIK-->noncanonical NF-kB signaling 9 NA NA 0.2850 -0.22800 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
NOTCH1 Intracellular Domain Regulates Transcription 9 NA NA 0.2140 -0.02060 0.085400 0.059300 -0.185000 -0.01710 NA NA NA NA NA
NOTCH2 Activation and Transmission of Signal to the Nucleus 6 NA NA 0.3220 -0.15900 NaN -0.188000 -0.207000 0.00744 NA NA NA NA NA
NOTCH3 Activation and Transmission of Signal to the Nucleus 7 NA NA 0.4670 0.21100 -0.121000 -0.188000 -0.207000 -0.28500 NA NA NA NA NA
NRAGE signals death through JNK 5 NA NA 0.3490 -0.26000 -0.110000 0.090500 0.089300 0.16100 NA NA NA NA NA
NRIF signals cell death from the nucleus 6 NA NA 0.3800 -0.25700 NaN -0.188000 -0.207000 0.01970 NA NA NA NA NA
Neddylation 28 NA NA 0.1320 0.00332 -0.074900 0.078900 -0.075000 -0.00722 NA NA NA NA NA
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 5 NA NA 0.6490 -0.23100 NaN -0.198000 0.086700 0.56700 NA NA NA NA NA
Negative epigenetic regulation of rRNA expression 7 NA NA 0.1810 0.08750 0.009880 -0.048000 0.061700 -0.13800 NA NA NA NA NA
Negative regulation of FGFR1 signaling 6 NA NA 0.2420 -0.09040 NaN -0.084800 -0.207000 0.01230 NA NA NA NA NA
Negative regulation of FGFR2 signaling 5 NA NA 0.2550 NaN NaN -0.084800 -0.207000 -0.12100 NA NA NA NA NA
Negative regulation of FGFR3 signaling 5 NA NA 0.2550 NaN NaN -0.084800 -0.207000 -0.12100 NA NA NA NA NA
Negative regulation of FGFR4 signaling 5 NA NA 0.2550 NaN NaN -0.084800 -0.207000 -0.12100 NA NA NA NA NA
Negative regulation of MAPK pathway 8 NA NA 0.3990 -0.34900 NaN 0.065900 -0.153000 -0.09980 NA NA NA NA NA
Negative regulation of NOTCH4 signaling 11 NA NA 0.2450 -0.12500 -0.070500 0.043400 0.018500 -0.19300 NA NA NA NA NA
Negative regulation of the PI3K/AKT network 9 NA NA 0.3140 -0.27300 NaN 0.018400 NaN 0.15400 NA NA NA NA NA
Nervous system development 126 NA NA 0.2020 -0.06210 0.160000 -0.083600 -0.055300 0.03550 NA NA NA NA NA
Netrin-1 signaling 7 NA NA 0.1430 NaN NaN 0.018400 0.019800 0.14000 NA NA NA NA NA
Neurodegenerative Diseases 6 NA NA 0.4040 -0.12700 0.000881 0.218000 -0.080100 -0.30600 NA NA NA NA NA
Neuronal System 24 NA NA 0.3270 -0.05210 0.076400 -0.096100 0.090700 0.28400 NA NA NA NA NA
Neurotransmitter receptors and postsynaptic signal transmission 13 NA NA 0.3370 0.03220 0.019700 0.014500 0.090700 0.32200 NA NA NA NA NA
Neurotransmitter release cycle 6 NA NA 0.4310 -0.15800 NaN -0.176000 NaN 0.36000 NA NA NA NA NA
Neutrophil degranulation 77 NA NA 0.1390 -0.09280 0.029700 -0.018600 -0.005770 0.09740 NA NA NA NA NA
NoRC negatively regulates rRNA expression 7 NA NA 0.1810 0.08750 0.009880 -0.048000 0.061700 -0.13800 NA NA NA NA NA
Non-integrin membrane-ECM interactions 6 NA NA 0.5020 -0.27500 0.156000 -0.108000 -0.053300 0.37100 NA NA NA NA NA
Nonhomologous End-Joining (NHEJ) 6 NA NA 0.3580 0.23600 0.061700 0.159000 NaN -0.20800 NA NA NA NA NA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 55 NA NA 0.4200 0.19200 0.176000 -0.131000 -0.154000 -0.26000 NA NA NA NA NA
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 51 NA NA 0.4230 0.16800 0.184000 -0.131000 -0.156000 -0.27400 NA NA NA NA NA
Nonsense-Mediated Decay (NMD) 55 NA NA 0.4200 0.19200 0.176000 -0.131000 -0.154000 -0.26000 NA NA NA NA NA
Nuclear Envelope (NE) Reassembly 20 NA NA 0.4630 0.16500 -0.075800 0.220000 -0.026800 -0.36400 NA NA NA NA NA
Nuclear Envelope Breakdown 9 NA NA 0.5330 0.19700 -0.116000 0.211000 -0.080100 -0.42500 NA NA NA NA NA
Nuclear Events (kinase and transcription factor activation) 11 NA NA 0.4120 -0.18600 0.080400 -0.157000 -0.021100 0.32200 NA NA NA NA NA
Nuclear Pore Complex (NPC) Disassembly 5 NA NA 0.5500 0.31500 -0.148000 0.202000 NaN -0.37500 NA NA NA NA NA
Nuclear import of Rev protein 6 NA NA 0.5970 0.20000 0.022300 0.197000 -0.108000 -0.51500 NA NA NA NA NA
Nuclear signaling by ERBB4 7 NA NA 0.4170 -0.25200 0.051500 -0.032700 0.002630 0.32700 NA NA NA NA NA
Nucleobase biosynthesis 6 NA NA 0.4830 0.22500 -0.038100 NaN NaN -0.42600 NA NA NA NA NA
Nucleosome assembly 13 NA NA 0.4790 0.12300 -0.109000 0.203000 -0.049900 -0.39800 NA NA NA NA NA
Nucleotide Excision Repair 21 NA NA 0.2860 0.17600 -0.062500 0.023600 -0.006440 -0.21500 NA NA NA NA NA
Oncogene Induced Senescence 9 NA NA 0.2110 0.02630 0.131000 -0.019200 -0.155000 0.04840 NA NA NA NA NA
Oncogenic MAPK signaling 11 NA NA 0.2590 -0.17300 0.112000 0.112000 -0.110000 -0.01320 NA NA NA NA NA
Opioid Signalling 6 NA NA 0.3120 -0.13300 0.019700 -0.094500 -0.031500 0.26300 NA NA NA NA NA
Orc1 removal from chromatin 17 NA NA 0.4280 0.26700 -0.103000 0.048600 -0.039500 -0.31300 NA NA NA NA NA
Organelle biogenesis and maintenance 39 NA NA 0.1740 0.01400 -0.048400 0.081100 -0.005550 -0.14500 NA NA NA NA NA
Oxidative Stress Induced Senescence 14 NA NA 0.2370 0.02720 0.029000 -0.019200 -0.207000 -0.10700 NA NA NA NA NA
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 10 NA NA 0.0657 -0.00262 -0.019700 0.043400 -0.039500 0.02190 NA NA NA NA NA
PCNA-Dependent Long Patch Base Excision Repair 6 NA NA 0.4240 0.25300 -0.079700 0.176000 NaN -0.28100 NA NA NA NA NA
PCP/CE pathway 15 NA NA 0.2160 0.19200 -0.019700 -0.045700 0.014500 -0.08450 NA NA NA NA NA
PERK regulates gene expression 5 NA NA 0.3620 0.27000 -0.061700 0.219000 NaN -0.08050 NA NA NA NA NA
PI3K/AKT Signaling in Cancer 9 NA NA 0.3190 -0.27300 NaN 0.071000 NaN 0.14800 NA NA NA NA NA
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 9 NA NA 0.3140 -0.27300 NaN 0.018400 NaN 0.15400 NA NA NA NA NA
PINK1-PRKN Mediated Mitophagy 10 NA NA 0.3350 0.06650 -0.017100 -0.030200 -0.207000 -0.25300 NA NA NA NA NA
PIP3 activates AKT signaling 23 NA NA 0.1550 -0.12500 -0.046800 0.063800 -0.039500 0.02270 NA NA NA NA NA
PIWI-interacting RNA (piRNA) biogenesis 6 NA NA 0.2510 0.13400 0.007250 0.042100 -0.036200 -0.20500 NA NA NA NA NA
PRC2 methylates histones and DNA 5 NA NA 0.2760 0.06160 -0.065900 NaN NaN -0.26100 NA NA NA NA NA
PTEN Regulation 13 NA NA 0.1300 -0.02540 -0.046800 0.058400 -0.039500 -0.09470 NA NA NA NA NA
Paradoxical activation of RAF signaling by kinase inactive BRAF 6 NA NA 0.2330 -0.20800 NaN 0.097100 NaN 0.03920 NA NA NA NA NA
Parasite infection 8 NA NA 0.4290 -0.35000 NaN -0.235000 0.052500 0.06360 NA NA NA NA NA
Pausing and recovery of HIV elongation 8 NA NA 0.2410 0.11500 0.023100 -0.184000 0.061700 -0.08340 NA NA NA NA NA
Pausing and recovery of Tat-mediated HIV elongation 8 NA NA 0.2410 0.11500 0.023100 -0.184000 0.061700 -0.08340 NA NA NA NA NA
Peptide chain elongation 50 NA NA 0.4240 0.17300 0.186000 -0.131000 -0.159000 -0.26900 NA NA NA NA NA
Peptide hormone metabolism 9 NA NA 0.2430 -0.23300 -0.024900 NaN 0.059000 0.02300 NA NA NA NA NA
Phase II - Conjugation of compounds 10 NA NA 0.1820 0.04540 NaN 0.092500 -0.096100 -0.11500 NA NA NA NA NA
Phospholipid metabolism 9 NA NA 0.1700 -0.09570 NaN 0.053000 -0.053700 0.11800 NA NA NA NA NA
Phosphorylation of the APC/C 5 NA NA 0.5480 0.23100 -0.150000 0.193000 NaN -0.43200 NA NA NA NA NA
Plasma lipoprotein assembly, remodeling, and clearance 10 NA NA 0.4020 -0.17300 0.138000 -0.060600 0.122000 0.30700 NA NA NA NA NA
Plasma lipoprotein clearance 7 NA NA 0.3580 -0.12100 0.105000 -0.003290 0.122000 0.29600 NA NA NA NA NA
Platelet activation, signaling and aggregation 38 NA NA 0.4590 -0.27400 0.167000 -0.084500 0.043600 0.31400 NA NA NA NA NA
Platelet degranulation 27 NA NA 0.5290 -0.34000 0.167000 -0.097800 0.050600 0.35200 NA NA NA NA NA
Platelet homeostasis 10 NA NA 0.5030 -0.25100 NaN -0.076900 -0.055300 0.42500 NA NA NA NA NA
Polo-like kinase mediated events 5 NA NA 0.6340 0.25500 -0.162000 0.258000 NaN -0.49500 NA NA NA NA NA
Post-chaperonin tubulin folding pathway 7 NA NA 0.5350 0.32200 -0.045100 0.182000 0.018500 -0.38200 NA NA NA NA NA
Post-translational modification: synthesis of GPI-anchored proteins 7 NA NA 0.3710 -0.20100 0.185000 -0.156000 0.057300 0.18900 NA NA NA NA NA
Postmitotic nuclear pore complex (NPC) reformation 5 NA NA 0.4000 0.19300 0.022300 0.198000 -0.108000 -0.26700 NA NA NA NA NA
Potential therapeutics for SARS 21 NA NA 0.0880 0.04590 -0.026300 0.022000 0.056600 -0.03520 NA NA NA NA NA
Pre-NOTCH Expression and Processing 5 NA NA 0.1860 0.18200 NaN -0.035400 NaN -0.02000 NA NA NA NA NA
Prefoldin mediated transfer of substrate to CCT/TriC 17 NA NA 0.2770 0.15400 0.008250 0.166000 -0.022200 -0.15700 NA NA NA NA NA
Processing of Capped Intron-Containing Pre-mRNA 60 NA NA 0.3970 0.21800 -0.038900 0.098300 -0.002920 -0.31400 NA NA NA NA NA
Processing of Capped Intronless Pre-mRNA 6 NA NA 0.5730 0.35500 -0.062300 0.147000 NaN -0.42000 NA NA NA NA NA
Processing of DNA double-strand break ends 11 NA NA 0.4400 0.27200 -0.094800 -0.000439 -0.207000 -0.26000 NA NA NA NA NA
Processing of SMDT1 5 NA NA 0.5650 0.27300 NaN NaN -0.051400 -0.49200 NA NA NA NA NA
Programmed Cell Death 29 NA NA 0.1910 -0.02760 -0.038900 0.148000 -0.061700 -0.09260 NA NA NA NA NA
Protein folding 22 NA NA 0.2800 0.19100 -0.013600 0.127000 -0.024200 -0.15900 NA NA NA NA NA
Protein localization 30 NA NA 0.3550 0.13700 0.014100 0.005330 0.025300 -0.32700 NA NA NA NA NA
Protein methylation 8 NA NA 0.2900 0.12600 0.202000 -0.121000 -0.111000 -0.02500 NA NA NA NA NA
Protein ubiquitination 12 NA NA 0.2750 0.04790 -0.162000 -0.056700 -0.115000 -0.17600 NA NA NA NA NA
Protein-protein interactions at synapses 5 NA NA 0.4670 -0.25100 0.133000 -0.095800 NaN 0.35800 NA NA NA NA NA
Purine ribonucleoside monophosphate biosynthesis 5 NA NA 0.4840 0.22600 -0.038100 NaN NaN -0.42600 NA NA NA NA NA
Pyruvate metabolism 5 NA NA 0.3660 0.18200 NaN 0.127000 NaN -0.29100 NA NA NA NA NA
Pyruvate metabolism and Citric Acid (TCA) cycle 9 NA NA 0.3660 0.15000 -0.056500 0.127000 NaN -0.30400 NA NA NA NA NA
RAB GEFs exchange GTP for GDP on RABs 6 NA NA 0.2430 -0.17000 NaN NaN NaN 0.17400 NA NA NA NA NA
RAB geranylgeranylation 5 NA NA 0.3570 -0.30200 NaN NaN -0.018400 0.19000 NA NA NA NA NA
RAF activation 7 NA NA 0.1960 -0.17200 NaN 0.074300 -0.053800 0.01890 NA NA NA NA NA
RAF-independent MAPK1/3 activation 7 NA NA 0.3670 0.09780 -0.095900 -0.057200 -0.098500 0.32100 NA NA NA NA NA
RAF/MAP kinase cascade 30 NA NA 0.2300 -0.16200 -0.019700 0.049300 -0.058300 0.14300 NA NA NA NA NA
RET signaling 5 NA NA 0.2360 NaN NaN -0.046700 NaN 0.23100 NA NA NA NA NA
RHO GTPase Effectors 48 NA NA 0.2090 -0.05730 -0.107000 0.106000 0.017200 -0.13100 NA NA NA NA NA
RHO GTPases Activate Formins 32 NA NA 0.3300 0.12000 -0.111000 0.139000 -0.022000 -0.25000 NA NA NA NA NA
RHO GTPases Activate WASPs and WAVEs 6 NA NA 0.4220 -0.35000 NaN -0.235000 NaN -0.00854 NA NA NA NA NA
RHO GTPases activate CIT 5 NA NA 0.4520 -0.35100 NaN -0.061900 -0.015800 0.27700 NA NA NA NA NA
RHO GTPases activate PKNs 8 NA NA 0.3330 -0.30700 NaN -0.050500 0.059300 0.10300 NA NA NA NA NA
RIPK1-mediated regulated necrosis 6 NA NA 0.3000 -0.10200 0.034900 -0.188000 -0.207000 -0.01740 NA NA NA NA NA
RMTs methylate histone arginines 8 NA NA 0.3280 0.16100 NaN 0.092700 -0.185000 -0.19700 NA NA NA NA NA
RNA Pol II CTD phosphorylation and interaction with CE 5 NA NA 0.2560 0.07050 0.077500 -0.184000 0.061700 -0.13000 NA NA NA NA NA
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 5 NA NA 0.2560 0.07050 0.077500 -0.184000 0.061700 -0.13000 NA NA NA NA NA
RNA Polymerase I Promoter Clearance 8 NA NA 0.2040 0.09380 0.077500 0.049600 0.061700 -0.14400 NA NA NA NA NA
RNA Polymerase I Promoter Escape 6 NA NA 0.2450 0.09380 0.077500 0.030200 0.061700 -0.20200 NA NA NA NA NA
RNA Polymerase I Transcription 8 NA NA 0.2040 0.09380 0.077500 0.049600 0.061700 -0.14400 NA NA NA NA NA
RNA Polymerase I Transcription Initiation 6 NA NA 0.1730 0.09380 0.077500 -0.048000 0.061700 -0.09420 NA NA NA NA NA
RNA Polymerase II HIV Promoter Escape 6 NA NA 0.2330 0.07050 0.038200 -0.184000 0.043500 -0.11000 NA NA NA NA NA
RNA Polymerase II Pre-transcription Events 9 NA NA 0.2340 0.11500 0.015000 -0.184000 0.043500 -0.07540 NA NA NA NA NA
RNA Polymerase II Promoter Escape 6 NA NA 0.2330 0.07050 0.038200 -0.184000 0.043500 -0.11000 NA NA NA NA NA
RNA Polymerase II Transcription Elongation 8 NA NA 0.2410 0.11500 0.023100 -0.184000 0.061700 -0.08340 NA NA NA NA NA
RNA Polymerase II Transcription Initiation 6 NA NA 0.2330 0.07050 0.038200 -0.184000 0.043500 -0.11000 NA NA NA NA NA
RNA Polymerase II Transcription Initiation And Promoter Clearance 6 NA NA 0.2330 0.07050 0.038200 -0.184000 0.043500 -0.11000 NA NA NA NA NA
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 6 NA NA 0.2330 0.07050 0.038200 -0.184000 0.043500 -0.11000 NA NA NA NA NA
RNA Polymerase II Transcription Termination 18 NA NA 0.4650 0.25700 -0.040400 0.122000 -0.122000 -0.34500 NA NA NA NA NA
RNA Polymerase III Abortive And Retractive Initiation 7 NA NA 0.3680 0.16400 0.042200 0.035600 -0.036900 -0.32300 NA NA NA NA NA
RNA Polymerase III Chain Elongation 5 NA NA 0.3870 0.16400 0.042200 -0.184000 0.061700 -0.28900 NA NA NA NA NA
RNA Polymerase III Transcription 7 NA NA 0.3680 0.16400 0.042200 0.035600 -0.036900 -0.32300 NA NA NA NA NA
RNA Polymerase III Transcription Initiation 6 NA NA 0.3810 0.16400 0.042200 -0.015100 -0.036900 -0.33800 NA NA NA NA NA
RNA Polymerase III Transcription Initiation From Type 1 Promoter 6 NA NA 0.3810 0.16400 0.042200 -0.015100 -0.036900 -0.33800 NA NA NA NA NA
RNA Polymerase III Transcription Initiation From Type 2 Promoter 5 NA NA 0.3870 0.16400 0.042200 -0.184000 0.061700 -0.28900 NA NA NA NA NA
RNA Polymerase III Transcription Initiation From Type 3 Promoter 5 NA NA 0.3870 0.16400 0.042200 -0.184000 0.061700 -0.28900 NA NA NA NA NA
RNA Polymerase III Transcription Termination 6 NA NA 0.3330 0.16400 0.042200 -0.023700 0.061700 -0.27900 NA NA NA NA NA
RNA polymerase II transcribes snRNA genes 7 NA NA 0.2270 0.04770 0.038200 -0.184000 0.043500 -0.11000 NA NA NA NA NA
RUNX1 regulates transcription of genes involved in differentiation of HSCs 10 NA NA 0.1300 -0.00262 -0.019700 0.043400 -0.039500 -0.11400 NA NA NA NA NA
Rab regulation of trafficking 8 NA NA 0.2170 -0.17000 NaN NaN -0.087600 0.10300 NA NA NA NA NA
Recognition of DNA damage by PCNA-containing replication complex 9 NA NA 0.4020 0.19800 -0.071600 -0.005920 -0.207000 -0.27200 NA NA NA NA NA
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 8 NA NA 0.3610 0.18000 0.053800 -0.074300 -0.207000 -0.21600 NA NA NA NA NA
Recruitment of NuMA to mitotic centrosomes 12 NA NA 0.3190 0.15900 -0.080500 0.111000 -0.130000 -0.20100 NA NA NA NA NA
Recruitment of mitotic centrosome proteins and complexes 12 NA NA 0.3190 0.15900 -0.080500 0.111000 -0.130000 -0.20100 NA NA NA NA NA
Recycling pathway of L1 5 NA NA 0.3920 NaN NaN NaN 0.012300 0.39100 NA NA NA NA NA
Regulated Necrosis 6 NA NA 0.3000 -0.10200 0.034900 -0.188000 -0.207000 -0.01740 NA NA NA NA NA
Regulation of APC/C activators between G1/S and early anaphase 18 NA NA 0.4330 0.15600 -0.140000 0.139000 -0.039500 -0.35000 NA NA NA NA NA
Regulation of Apoptosis 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Regulation of HSF1-mediated heat shock response 12 NA NA 0.3600 0.24100 0.014500 0.100000 0.143000 -0.20300 NA NA NA NA NA
Regulation of MECP2 expression and activity 6 NA NA 0.3340 -0.20500 -0.051200 0.125000 -0.206000 0.09520 NA NA NA NA NA
Regulation of PLK1 Activity at G2/M Transition 17 NA NA 0.3560 0.10200 -0.103000 0.111000 -0.157000 -0.26200 NA NA NA NA NA
Regulation of PTEN gene transcription 5 NA NA 0.1280 -0.03670 -0.073500 0.087900 NaN -0.04230 NA NA NA NA NA
Regulation of PTEN stability and activity 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Regulation of RAS by GAPs 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Regulation of RUNX1 Expression and Activity 5 NA NA 0.2510 -0.17700 0.060400 -0.048900 NaN 0.16100 NA NA NA NA NA
Regulation of RUNX2 expression and activity 11 NA NA 0.2370 -0.22800 -0.019700 0.043400 -0.039500 -0.02020 NA NA NA NA NA
Regulation of RUNX3 expression and activity 11 NA NA 0.1510 -0.00262 -0.019700 0.070300 -0.090300 -0.09700 NA NA NA NA NA
Regulation of TP53 Activity 19 NA NA 0.3490 0.23300 -0.095600 0.084900 -0.138000 -0.18000 NA NA NA NA NA
Regulation of TP53 Activity through Phosphorylation 14 NA NA 0.4300 0.23100 -0.095000 0.084000 -0.138000 -0.31100 NA NA NA NA NA
Regulation of TP53 Degradation 8 NA NA 0.4050 0.30300 -0.125000 -0.018000 -0.207000 -0.11500 NA NA NA NA NA
Regulation of TP53 Expression and Degradation 8 NA NA 0.4050 0.30300 -0.125000 -0.018000 -0.207000 -0.11500 NA NA NA NA NA
Regulation of actin dynamics for phagocytic cup formation 9 NA NA 0.1720 -0.01440 -0.063000 0.003950 -0.034200 -0.15600 NA NA NA NA NA
Regulation of activated PAK-2p34 by proteasome mediated degradation 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Regulation of cholesterol biosynthesis by SREBP (SREBF) 5 NA NA 0.4710 0.07490 0.022300 0.276000 -0.106000 -0.35800 NA NA NA NA NA
Regulation of expression of SLITs and ROBOs 63 NA NA 0.3620 0.18000 0.168000 -0.096700 -0.137000 -0.20600 NA NA NA NA NA
Regulation of insulin secretion 6 NA NA 0.3770 -0.10800 NaN -0.015700 -0.106000 0.34500 NA NA NA NA NA
Regulation of mRNA stability by proteins that bind AU-rich elements 19 NA NA 0.2500 0.09380 -0.035100 0.086900 -0.015200 -0.21200 NA NA NA NA NA
Regulation of mitotic cell cycle 20 NA NA 0.4410 0.15600 -0.137000 0.153000 -0.039500 -0.35500 NA NA NA NA NA
Regulation of necroptotic cell death 6 NA NA 0.3000 -0.10200 0.034900 -0.188000 -0.207000 -0.01740 NA NA NA NA NA
Reproduction 11 NA NA 0.2770 0.05030 -0.069100 0.133000 -0.023000 -0.22600 NA NA NA NA NA
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 7 NA NA 0.4520 0.28400 -0.097500 0.112000 NaN -0.31800 NA NA NA NA NA
Resolution of Abasic Sites (AP sites) 9 NA NA 0.4170 0.28400 -0.097500 0.018900 NaN -0.28900 NA NA NA NA NA
Resolution of Sister Chromatid Cohesion 30 NA NA 0.4820 0.22500 -0.114000 0.194000 -0.025000 -0.36100 NA NA NA NA NA
Respiratory electron transport 25 NA NA 0.3830 -0.05310 0.042800 -0.056100 0.095300 -0.36100 NA NA NA NA NA
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 34 NA NA 0.3690 -0.11500 0.042800 -0.080800 0.104000 -0.32200 NA NA NA NA NA
Response of EIF2AK4 (GCN2) to amino acid deficiency 51 NA NA 0.3930 0.15200 0.184000 -0.092200 -0.156000 -0.25400 NA NA NA NA NA
Response of Mtb to phagocytosis 7 NA NA 0.4480 0.15200 0.033600 0.051400 -0.207000 -0.36200 NA NA NA NA NA
Response to elevated platelet cytosolic Ca2+ 27 NA NA 0.5290 -0.34000 0.167000 -0.097800 0.050600 0.35200 NA NA NA NA NA
Retinoid metabolism and transport 7 NA NA 0.5370 -0.34500 0.099800 -0.087400 -0.003940 0.38900 NA NA NA NA NA
Rev-mediated nuclear export of HIV RNA 6 NA NA 0.7900 0.29300 -0.177000 0.190000 -0.108000 -0.67700 NA NA NA NA NA
Rho GTPase cycle 9 NA NA 0.2170 -0.02940 0.030300 -0.111000 0.036900 0.17800 NA NA NA NA NA
Ribosomal scanning and start codon recognition 26 NA NA 0.3700 0.12600 0.159000 0.086600 -0.127000 -0.26800 NA NA NA NA NA
S Phase 34 NA NA 0.4830 0.28900 -0.102000 0.099600 -0.072600 -0.35200 NA NA NA NA NA
SARS-CoV Infections 29 NA NA 0.0509 -0.02870 -0.026300 0.019200 0.020400 -0.01700 NA NA NA NA NA
SARS-CoV-1 Infection 6 NA NA 0.3170 -0.14000 NaN -0.188000 -0.207000 -0.05210 NA NA NA NA NA
SARS-CoV-2 Infection 9 NA NA 0.2840 -0.26700 NaN 0.008550 -0.052000 0.08180 NA NA NA NA NA
SCF(Skp2)-mediated degradation of p27/p21 13 NA NA 0.2690 0.02830 -0.126000 0.058300 -0.039500 -0.22500 NA NA NA NA NA
SCF-beta-TrCP mediated degradation of Emi1 10 NA NA 0.2440 -0.08540 -0.079700 0.101000 -0.039500 -0.18400 NA NA NA NA NA
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 5 NA NA 0.4100 -0.32200 NaN -0.074800 NaN 0.24300 NA NA NA NA NA
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 6 NA NA 0.5730 0.35500 -0.062300 0.147000 NaN -0.42000 NA NA NA NA NA
SLBP independent Processing of Histone Pre-mRNAs 5 NA NA 0.6480 0.35700 -0.086300 0.147000 NaN -0.51300 NA NA NA NA NA
SLC transporter disorders 6 NA NA 0.2090 0.09510 NaN 0.086600 0.156000 0.05120 NA NA NA NA NA
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 7 NA NA 0.3290 0.19900 0.109000 -0.107000 -0.173000 -0.12400 NA NA NA NA NA
SRP-dependent cotranslational protein targeting to membrane 57 NA NA 0.3640 0.03160 0.184000 -0.074200 -0.085300 -0.29100 NA NA NA NA NA
SUMO E3 ligases SUMOylate target proteins 23 NA NA 0.4320 0.22100 -0.102000 0.139000 -0.217000 -0.24600 NA NA NA NA NA
SUMOylation 25 NA NA 0.4240 0.22100 -0.100000 0.131000 -0.217000 -0.23800 NA NA NA NA NA
SUMOylation of DNA damage response and repair proteins 6 NA NA 0.4050 0.32100 -0.084100 0.095800 NaN -0.21100 NA NA NA NA NA
SUMOylation of DNA replication proteins 9 NA NA 0.4500 0.28000 -0.124000 0.161000 NaN -0.28800 NA NA NA NA NA
SUMOylation of RNA binding proteins 5 NA NA 0.3730 0.31800 NaN 0.086600 NaN -0.17400 NA NA NA NA NA
SUMOylation of transcription cofactors 6 NA NA 0.3750 0.04600 NaN 0.133000 -0.217000 -0.27100 NA NA NA NA NA
Scavenging by Class A Receptors 5 NA NA 0.6330 -0.35400 0.167000 -0.073500 NaN 0.49200 NA NA NA NA NA
Sealing of the nuclear envelope (NE) by ESCRT-III 8 NA NA 0.4600 0.17100 -0.045100 0.182000 0.018500 -0.38200 NA NA NA NA NA
Selective autophagy 15 NA NA 0.3020 0.05550 -0.040200 -0.030200 -0.207000 -0.20700 NA NA NA NA NA
Selenoamino acid metabolism 51 NA NA 0.3940 0.16200 0.184000 -0.093100 -0.156000 -0.25000 NA NA NA NA NA
Selenocysteine synthesis 48 NA NA 0.4290 0.16200 0.184000 -0.131000 -0.156000 -0.28600 NA NA NA NA NA
Sema4D in semaphorin signaling 5 NA NA 0.5230 -0.34400 NaN -0.158000 -0.015800 0.36000 NA NA NA NA NA
Semaphorin interactions 16 NA NA 0.3550 -0.23200 -0.063000 -0.061300 0.022100 0.25300 NA NA NA NA NA
Separation of Sister Chromatids 38 NA NA 0.4560 0.19100 -0.114000 0.172000 -0.032500 -0.35700 NA NA NA NA NA
Signaling by BRAF and RAF fusions 8 NA NA 0.4050 -0.26300 0.112000 0.131000 -0.137000 0.21600 NA NA NA NA NA
Signaling by EGFR 8 NA NA 0.3090 NaN NaN -0.084800 -0.207000 0.21300 NA NA NA NA NA
Signaling by EGFR in Cancer 5 NA NA 0.4610 0.32100 -0.063000 -0.188000 -0.207000 -0.16600 NA NA NA NA NA
Signaling by ERBB2 7 NA NA 0.4590 0.32100 -0.063000 -0.188000 -0.207000 -0.16000 NA NA NA NA NA
Signaling by ERBB4 12 NA NA 0.2810 -0.25200 0.051500 -0.055300 -0.067800 0.07400 NA NA NA NA NA
Signaling by FGFR 16 NA NA 0.1840 0.08510 0.077500 -0.118000 -0.073100 -0.03640 NA NA NA NA NA
Signaling by FGFR in disease 7 NA NA 0.2200 0.02980 0.077500 -0.184000 0.061700 -0.06190 NA NA NA NA NA
Signaling by FGFR1 7 NA NA 0.2560 -0.09040 NaN -0.084800 -0.207000 0.08310 NA NA NA NA NA
Signaling by FGFR2 15 NA NA 0.2110 0.12000 0.077500 -0.118000 -0.073100 -0.06800 NA NA NA NA NA
Signaling by FGFR2 IIIa TM 5 NA NA 0.2560 0.07050 0.077500 -0.184000 0.061700 -0.13000 NA NA NA NA NA
Signaling by FGFR2 in disease 5 NA NA 0.2560 0.07050 0.077500 -0.184000 0.061700 -0.13000 NA NA NA NA NA
Signaling by FGFR3 6 NA NA 0.2250 NaN NaN -0.084800 -0.207000 0.01790 NA NA NA NA NA
Signaling by FGFR4 6 NA NA 0.2250 NaN NaN -0.084800 -0.207000 0.01790 NA NA NA NA NA
Signaling by Hedgehog 12 NA NA 0.3310 -0.30500 -0.019700 0.043400 -0.039500 0.11300 NA NA NA NA NA
Signaling by Insulin receptor 6 NA NA 0.4130 -0.15000 NaN -0.089400 0.152000 0.34300 NA NA NA NA NA
Signaling by Interleukins 62 NA NA 0.1500 -0.09230 -0.025100 0.059000 -0.059200 0.08030 NA NA NA NA NA
Signaling by Ligand-Responsive EGFR Variants in Cancer 5 NA NA 0.4610 0.32100 -0.063000 -0.188000 -0.207000 -0.16600 NA NA NA NA NA
Signaling by MET 10 NA NA 0.3410 -0.23800 0.156000 -0.101000 -0.061900 0.14400 NA NA NA NA NA
Signaling by NOTCH 29 NA NA 0.1480 0.02150 -0.013600 0.115000 -0.058500 -0.06780 NA NA NA NA NA
Signaling by NOTCH1 12 NA NA 0.2300 -0.07270 0.085400 0.059300 -0.185000 0.05120 NA NA NA NA NA
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 10 NA NA 0.2250 -0.07270 0.085400 0.059300 -0.185000 -0.01530 NA NA NA NA NA
Signaling by NOTCH1 PEST Domain Mutants in Cancer 10 NA NA 0.2250 -0.07270 0.085400 0.059300 -0.185000 -0.01530 NA NA NA NA NA
Signaling by NOTCH1 in Cancer 10 NA NA 0.2250 -0.07270 0.085400 0.059300 -0.185000 -0.01530 NA NA NA NA NA
Signaling by NOTCH2 6 NA NA 0.3220 -0.15900 NaN -0.188000 -0.207000 0.00744 NA NA NA NA NA
Signaling by NOTCH3 11 NA NA 0.2870 0.11800 -0.044500 0.063700 -0.207000 -0.14000 NA NA NA NA NA
Signaling by NOTCH4 14 NA NA 0.1690 -0.14600 -0.070500 0.043400 0.018500 -0.01340 NA NA NA NA NA
Signaling by NTRK1 (TRKA) 17 NA NA 0.4130 -0.22700 0.080400 -0.022800 0.026900 0.33300 NA NA NA NA NA
Signaling by NTRKs 21 NA NA 0.3850 -0.22700 0.080400 -0.012600 0.026900 0.29900 NA NA NA NA NA
Signaling by Non-Receptor Tyrosine Kinases 11 NA NA 0.2440 0.11700 0.044600 -0.009230 -0.207000 -0.02950 NA NA NA NA NA
Signaling by PDGF 11 NA NA 0.4890 -0.29600 0.118000 -0.073400 -0.022300 0.36200 NA NA NA NA NA
Signaling by PTK6 11 NA NA 0.2440 0.11700 0.044600 -0.009230 -0.207000 -0.02950 NA NA NA NA NA
Signaling by RAS mutants 6 NA NA 0.2330 -0.20800 NaN 0.097100 NaN 0.03920 NA NA NA NA NA
Signaling by ROBO receptors 68 NA NA 0.3360 0.15400 0.168000 -0.090400 -0.129000 -0.19100 NA NA NA NA NA
Signaling by Receptor Tyrosine Kinases 69 NA NA 0.3340 -0.18400 0.073300 -0.088600 0.015800 0.25400 NA NA NA NA NA
Signaling by Retinoic Acid 7 NA NA 0.4330 0.00832 NaN NaN 0.167000 0.39900 NA NA NA NA NA
Signaling by Rho GTPases 55 NA NA 0.1660 -0.04700 -0.095900 0.093700 0.031900 -0.08040 NA NA NA NA NA
Signaling by TGF-beta Receptor Complex 18 NA NA 0.2160 0.11600 0.021200 0.036900 -0.119000 -0.13100 NA NA NA NA NA
Signaling by TGFB family members 22 NA NA 0.1660 0.09920 0.034100 0.016900 -0.119000 0.04680 NA NA NA NA NA
Signaling by VEGF 11 NA NA 0.2970 -0.14900 0.023100 -0.139000 NaN 0.21500 NA NA NA NA NA
Signaling by WNT 35 NA NA 0.1450 -0.01230 0.074900 -0.082300 -0.040100 0.08290 NA NA NA NA NA
Signaling by moderate kinase activity BRAF mutants 6 NA NA 0.2330 -0.20800 NaN 0.097100 NaN 0.03920 NA NA NA NA NA
Signaling by the B Cell Receptor (BCR) 15 NA NA 0.2850 -0.27000 0.063900 0.042900 -0.008370 0.04540 NA NA NA NA NA
Signaling downstream of RAS mutants 6 NA NA 0.2330 -0.20800 NaN 0.097100 NaN 0.03920 NA NA NA NA NA
Smooth Muscle Contraction 11 NA NA 0.5620 -0.27000 0.100000 -0.150000 -0.064700 0.45500 NA NA NA NA NA
Spry regulation of FGF signaling 5 NA NA 0.2550 NaN NaN -0.084800 -0.207000 -0.12100 NA NA NA NA NA
Stabilization of p53 9 NA NA 0.1800 -0.00262 -0.019700 0.070300 -0.039500 -0.15900 NA NA NA NA NA
Stimuli-sensing channels 8 NA NA 0.4230 -0.35300 NaN -0.141000 -0.123000 0.13900 NA NA NA NA NA
Switching of origins to a post-replicative state 19 NA NA 0.4670 0.25900 -0.120000 0.077000 -0.039500 -0.36000 NA NA NA NA NA
Synthesis of DNA 27 NA NA 0.4730 0.27300 -0.113000 0.091600 -0.039500 -0.35600 NA NA NA NA NA
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 7 NA NA 0.4740 0.11500 -0.180000 0.025500 -0.207000 -0.36800 NA NA NA NA NA
TCF dependent signaling in response to WNT 24 NA NA 0.1330 0.04420 0.074900 -0.042900 -0.068400 0.06060 NA NA NA NA NA
TCR signaling 14 NA NA 0.2370 -0.22800 -0.019700 0.043400 -0.039500 0.00103 NA NA NA NA NA
TGF-beta receptor signaling activates SMADs 12 NA NA 0.1620 -0.00876 0.015800 -0.026800 -0.091100 -0.13100 NA NA NA NA NA
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 5 NA NA 0.4880 NaN NaN -0.188000 -0.115000 -0.43500 NA NA NA NA NA
TNFR2 non-canonical NF-kB pathway 11 NA NA 0.2140 -0.12300 0.043500 0.006150 -0.058600 -0.15900 NA NA NA NA NA
TP53 Regulates Metabolic Genes 11 NA NA 0.5360 -0.17900 0.060600 0.215000 0.156000 -0.42600 NA NA NA NA NA
TP53 Regulates Transcription of Cell Cycle Genes 10 NA NA 0.4050 0.18600 -0.117000 0.134000 NaN -0.31300 NA NA NA NA NA
TP53 Regulates Transcription of Cell Death Genes 7 NA NA 0.2020 0.05490 -0.000659 0.050900 -0.151000 -0.11200 NA NA NA NA NA
TP53 Regulates Transcription of DNA Repair Genes 11 NA NA 0.1450 0.08470 -0.029100 -0.037500 0.061700 -0.08910 NA NA NA NA NA
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 7 NA NA 0.3730 0.22900 -0.107000 0.140000 NaN -0.23500 NA NA NA NA NA
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
TRIF(TICAM1)-mediated TLR4 signaling 13 NA NA 0.2310 -0.23000 -0.003950 -0.000265 0.001980 -0.02060 NA NA NA NA NA
Tat-mediated HIV elongation arrest and recovery 8 NA NA 0.2410 0.11500 0.023100 -0.184000 0.061700 -0.08340 NA NA NA NA NA
Tat-mediated elongation of the HIV-1 transcript 8 NA NA 0.2410 0.11500 0.023100 -0.184000 0.061700 -0.08340 NA NA NA NA NA
Telomere C-strand (Lagging Strand) Synthesis 5 NA NA 0.4560 0.30200 -0.079700 0.176000 NaN -0.28100 NA NA NA NA NA
Telomere Extension By Telomerase 5 NA NA 0.4750 0.33100 -0.044800 0.019100 0.068300 -0.33000 NA NA NA NA NA
Telomere Maintenance 15 NA NA 0.3490 0.23600 -0.042300 0.007600 0.065200 -0.24500 NA NA NA NA NA
Termination of translesion DNA synthesis 9 NA NA 0.5170 0.27900 -0.104000 -0.005920 -0.207000 -0.36800 NA NA NA NA NA
The citric acid (TCA) cycle and respiratory electron transport 42 NA NA 0.3610 -0.06770 0.009690 -0.046000 0.104000 -0.33600 NA NA NA NA NA
The role of GTSE1 in G2/M progression after G2 checkpoint 16 NA NA 0.4510 0.23800 -0.116000 0.168000 -0.066900 -0.31700 NA NA NA NA NA
The role of Nef in HIV-1 replication and disease pathogenesis 7 NA NA 0.4910 -0.23100 NaN -0.198000 0.086700 0.37600 NA NA NA NA NA
Toll Like Receptor 10 (TLR10) Cascade 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
Toll Like Receptor 2 (TLR2) Cascade 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
Toll Like Receptor 3 (TLR3) Cascade 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
Toll Like Receptor 4 (TLR4) Cascade 14 NA NA 0.2300 -0.23000 -0.003950 -0.000265 0.001980 -0.00616 NA NA NA NA NA
Toll Like Receptor 5 (TLR5) Cascade 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
Toll Like Receptor 7/8 (TLR7/8) Cascade 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
Toll Like Receptor 9 (TLR9) Cascade 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
Toll Like Receptor TLR1:TLR2 Cascade 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
Toll Like Receptor TLR6:TLR2 Cascade 12 NA NA 0.2310 -0.23000 -0.003950 -0.004950 0.001980 -0.02060 NA NA NA NA NA
Toll-like Receptor Cascades 19 NA NA 0.2480 -0.23500 0.028600 -0.042300 0.014100 0.05920 NA NA NA NA NA
Trafficking of AMPA receptors 6 NA NA 0.5750 0.14200 NaN 0.123000 0.151000 0.52200 NA NA NA NA NA
Transcription of the HIV genome 9 NA NA 0.2340 0.11500 0.015000 -0.184000 0.043500 -0.07540 NA NA NA NA NA
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 15 NA NA 0.2420 0.14700 -0.040400 0.017200 -0.021800 -0.18600 NA NA NA NA NA
Transcriptional Regulation by E2F6 5 NA NA 0.5390 0.40300 -0.092900 0.244000 NaN -0.24500 NA NA NA NA NA
Transcriptional Regulation by MECP2 9 NA NA 0.3450 -0.18600 -0.051200 0.087900 -0.206000 0.17800 NA NA NA NA NA
Transcriptional Regulation by TP53 53 NA NA 0.2440 0.04770 -0.060900 0.097700 0.032500 -0.20700 NA NA NA NA NA
Transcriptional Regulation by VENTX 5 NA NA 0.3800 0.17300 -0.075800 0.076400 NaN -0.32100 NA NA NA NA NA
Transcriptional activation of mitochondrial biogenesis 8 NA NA 0.2400 -0.02020 0.007250 0.077300 -0.206000 -0.09390 NA NA NA NA NA
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 9 NA NA 0.3230 0.19000 0.022900 0.028100 -0.185000 -0.18100 NA NA NA NA NA
Transcriptional regulation by RUNX1 23 NA NA 0.0815 -0.02660 0.063000 -0.014700 -0.039500 -0.01370 NA NA NA NA NA
Transcriptional regulation by RUNX2 19 NA NA 0.2000 -0.13000 -0.097400 0.048700 -0.039500 0.09780 NA NA NA NA NA
Transcriptional regulation by RUNX3 17 NA NA 0.1330 0.01580 0.076900 0.030200 -0.103000 -0.00469 NA NA NA NA NA
Transcriptional regulation by small RNAs 8 NA NA 0.2950 0.14400 0.077500 0.059800 -0.023000 -0.23600 NA NA NA NA NA
Transcriptional regulation of white adipocyte differentiation 5 NA NA 0.3600 -0.05640 NaN 0.277000 -0.199000 0.10200 NA NA NA NA NA
Translation 101 NA NA 0.3500 0.12300 0.173000 -0.033700 -0.077800 -0.26500 NA NA NA NA NA
Translation initiation complex formation 26 NA NA 0.3880 0.13300 0.159000 0.086600 -0.127000 -0.29000 NA NA NA NA NA
Translesion Synthesis by POLH 6 NA NA 0.4640 0.28200 -0.079700 -0.005920 -0.207000 -0.29400 NA NA NA NA NA
Translesion synthesis by POLI 6 NA NA 0.4640 0.28200 -0.079700 -0.005920 -0.207000 -0.29400 NA NA NA NA NA
Translesion synthesis by POLK 6 NA NA 0.4640 0.28200 -0.079700 -0.005920 -0.207000 -0.29400 NA NA NA NA NA
Translesion synthesis by REV1 6 NA NA 0.4640 0.28200 -0.079700 -0.005920 -0.207000 -0.29400 NA NA NA NA NA
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 9 NA NA 0.5170 0.27900 -0.104000 -0.005920 -0.207000 -0.36800 NA NA NA NA NA
Translocation of SLC2A4 (GLUT4) to the plasma membrane 7 NA NA 0.4840 -0.35900 NaN 0.075600 0.057900 0.31100 NA NA NA NA NA
Transmission across Chemical Synapses 19 NA NA 0.3190 0.00162 0.019700 -0.081300 0.090700 0.29400 NA NA NA NA NA
Transport of Mature Transcript to Cytoplasm 15 NA NA 0.3950 0.25200 -0.019700 0.083900 -0.122000 -0.26400 NA NA NA NA NA
Transport of Mature mRNA derived from an Intron-Containing Transcript 14 NA NA 0.4110 0.24200 -0.024700 0.083900 -0.122000 -0.29500 NA NA NA NA NA
Transport of bile salts and organic acids, metal ions and amine compounds 5 NA NA 0.1520 -0.14300 NaN -0.011800 0.001320 0.05080 NA NA NA NA NA
Transport of inorganic cations/anions and amino acids/oligopeptides 12 NA NA 0.2800 0.05980 NaN -0.162000 0.156000 0.15500 NA NA NA NA NA
Transport to the Golgi and subsequent modification 13 NA NA 0.2100 -0.13500 NaN -0.049900 -0.005630 0.15200 NA NA NA NA NA
UCH proteinases 14 NA NA 0.2420 0.17000 -0.001980 0.003080 -0.020500 -0.17100 NA NA NA NA NA
Ub-specific processing proteases 20 NA NA 0.3470 0.25700 -0.064100 0.094700 -0.072600 -0.18900 NA NA NA NA NA
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
Ubiquitin-dependent degradation of Cyclin D 10 NA NA 0.1260 -0.00262 -0.019700 0.017100 -0.039500 -0.11700 NA NA NA NA NA
Unwinding of DNA 7 NA NA 0.5940 0.39300 -0.096800 0.095800 NaN -0.42400 NA NA NA NA NA
Uptake and actions of bacterial toxins 8 NA NA 0.1420 -0.06720 -0.063000 0.008920 -0.043500 0.09900 NA NA NA NA NA
VEGFA-VEGFR2 Pathway 10 NA NA 0.3120 -0.16000 0.023100 -0.139000 NaN 0.22800 NA NA NA NA NA
VEGFR2 mediated vascular permeability 6 NA NA 0.2430 -0.15800 0.023100 -0.092700 NaN 0.15800 NA NA NA NA NA
Vasopressin regulates renal water homeostasis via Aquaporins 5 NA NA 0.4840 -0.26700 NaN NaN -0.025000 0.40300 NA NA NA NA NA
Vesicle-mediated transport 65 NA NA 0.2570 -0.21300 0.001010 -0.029400 0.025600 0.13800 NA NA NA NA NA
Vif-mediated degradation of APOBEC3G 9 NA NA 0.0722 -0.00262 -0.019700 0.043400 -0.039500 -0.03710 NA NA NA NA NA
Viral Messenger RNA Synthesis 7 NA NA 0.2300 0.15400 0.077500 -0.048700 0.061700 -0.13000 NA NA NA NA NA
Viral mRNA Translation 49 NA NA 0.4240 0.16200 0.184000 -0.131000 -0.144000 -0.28600 NA NA NA NA NA
Visual phototransduction 11 NA NA 0.4620 -0.34800 0.099800 -0.079200 0.023000 0.27500 NA NA NA NA NA
Vpu mediated degradation of CD4 9 NA NA 0.2850 -0.22800 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
mRNA 3'-end processing 12 NA NA 0.4000 0.22600 -0.024700 0.082200 -0.122000 -0.29500 NA NA NA NA NA
mRNA Capping 5 NA NA 0.2560 0.07050 0.077500 -0.184000 0.061700 -0.13000 NA NA NA NA NA
mRNA Splicing 55 NA NA 0.4040 0.21300 -0.039200 0.098600 -0.002920 -0.32700 NA NA NA NA NA
mRNA Splicing - Major Pathway 54 NA NA 0.4060 0.21700 -0.039200 0.098600 -0.002920 -0.32700 NA NA NA NA NA
mRNA Splicing - Minor Pathway 19 NA NA 0.4990 0.24400 -0.037100 0.053500 0.061700 -0.42600 NA NA NA NA NA
mRNA decay by 5' to 3' exoribonuclease 6 NA NA 0.5540 0.21400 -0.037800 0.145000 NaN -0.48800 NA NA NA NA NA
p53-Dependent G1 DNA Damage Response 11 NA NA 0.2930 0.13500 -0.086900 0.055500 -0.039500 -0.23500 NA NA NA NA NA
p53-Dependent G1/S DNA damage checkpoint 11 NA NA 0.2930 0.13500 -0.086900 0.055500 -0.039500 -0.23500 NA NA NA NA NA
p53-Independent DNA Damage Response 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
p53-Independent G1/S DNA damage checkpoint 8 NA NA 0.1710 -0.00262 -0.019700 0.043400 -0.039500 -0.15900 NA NA NA NA NA
p75 NTR receptor-mediated signalling 13 NA NA 0.3230 -0.25700 -0.110000 -0.059500 -0.059300 0.13800 NA NA NA NA NA
p75NTR recruits signalling complexes 5 NA NA 0.3890 -0.27000 NaN -0.188000 -0.207000 0.01970 NA NA NA NA NA
p75NTR signals via NF-kB 5 NA NA 0.3890 -0.27000 NaN -0.188000 -0.207000 0.01970 NA NA NA NA NA
rRNA modification in the nucleus and cytosol 19 NA NA 0.4160 0.21900 0.116000 0.094900 -0.112000 -0.30000 NA NA NA NA NA
snRNP Assembly 8 NA NA 0.6830 0.38300 -0.089800 0.132000 NaN -0.54200 NA NA NA NA NA
tRNA processing 5 NA NA 0.5820 0.28100 0.047300 0.181000 -0.108000 -0.46100 NA NA NA NA NA
tRNA processing in the nucleus 5 NA NA 0.5820 0.28100 0.047300 0.181000 -0.108000 -0.46100 NA NA NA NA NA
trans-Golgi Network Vesicle Budding 6 NA NA 0.4310 -0.30400 0.167000 -0.223000 0.108000 -0.06290 NA NA NA NA NA



Detailed Gene set reports


B-WICH complex positively regulates rRNA expression

B-WICH complex positively regulates rRNA expression
metric value
setSize 8
pMANOVA 5.07e-06
p.adjustMANOVA 2.59e-05
s.dist 0.274
s.clus_0 0.111
s.clus_1 -0.0101
s.clus_2 0.0365
s.clus_3 -0.0309
s.clus_4 -0.246
p.clus_0 0.913
p.clus_1 0.000207
p.clus_2 0.044
p.clus_3 0.358
p.clus_4 0.4


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Top 20 genes
Gene clus_4 clus_0
POLR2F -615 302
DDX21 -437 187
POLR2H -284 140
BAZ1B -170 139
DEK -419 50

Click HERE to show all gene set members

All member genes
clus_0 clus_1 clus_2 clus_3 clus_4
POLR2F 302 -18 NA NA -615
DDX21 187 NA NA NA -437
POLR1E 149 NA NA NA NA
POLR2H 140 NA NA NA -284
BAZ1B 139 -36 27 NA -170
DEK 50 -200 190 -49 -419
POLR2L -206 NA -143 92 303
H2AFX NA NA NA NA -230





Developmental Biology

Developmental Biology
metric value
setSize 157
pMANOVA 5.07e-06
p.adjustMANOVA 2.59e-05
s.dist 0.181
s.clus_0 -0.0591
s.clus_1 0.138
s.clus_2 -0.0638
s.clus_3 -0.0597
s.clus_4 0.0492
p.clus_0 0.913
p.clus_1 0.000207
p.clus_2 0.044
p.clus_3 0.358
p.clus_4 0.4


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Top 20 genes
Gene clus_1 clus_2
RPL32 74 -201
ITGA10 48 -77
TSC22D1 45 -6

Click HERE to show all gene set members

All member genes
clus_0 clus_1 clus_2 clus_3 clus_4
MYL6 -342 NA -117 NA 439
RNPS1 368 NA NA -48 -217
MYC 367 -12 NA -60 -492
TFDP1 353 NA NA NA -254
RPS2 322 NA NA -96 -397
RPL12 316 NA NA NA -273
POLR2F 302 -18 NA NA -615
RPS6 301 41 NA -97 -19
RPSA 292 NA NA -69 -530
RPL9 272 NA NA NA NA
HSP90AA1 270 -125 NA NA -351
RPL4 257 NA NA NA -280
COL6A2 -312 NA -133 NA 403
MAGOHB 219 -71 NA NA -475
RPL30 -307 NA NA NA NA
SMARCA4 198 NA NA NA -54
GSPT1 195 NA NA NA -120
RPLP0 186 NA NA -75 -474
RBM8A 177 NA NA NA -33
RPS21 -296 NA 177 NA -6
COL6A1 -290 NA -157 28 236
KRT10 -289 NA NA NA NA
TSC22D1 -287 45 -6 NA 304
POLR2H 140 NA NA NA -284
RPL22L1 126 NA -34 NA -16
ITGB1 -282 NA -85 NA 420
PFN2 115 NA NA NA NA
MAGOH 105 NA NA NA -88
MYL12B -257 NA NA NA 174
DEK 50 -200 190 -49 -419
HSPA8 45 NA NA NA -126
CAPNS1 -250 NA NA NA NA
ARPC3 -242 NA NA NA NA
PSMA3 23 NA NA NA -105
MMP9 -226 NA -39 NA 419
RRAS -221 NA -60 NA 383
MBP -214 NA NA 127 NA
POLR2L -206 NA -143 92 303
SDCBP -205 NA NA NA 275
MYL12A -168 NA -192 NA 393
GPC1 -156 NA -21 42 NA
NRCAM -155 NA NA NA 262
PSENEN -149 NA NA NA NA
CTNNA1 -131 NA NA NA NA
CHL1 -129 NA NA 18 NA
RHOC -127 NA -191 33 NA
KCNQ2 -119 NA NA NA NA
ITGAV -103 NA NA NA 336
ITGA1 -93 NA -24 -3 457
MEF2C -87 NA -48 NA 351
GAP43 -80 NA -108 36 101
SPTBN1 -69 NA NA NA 242
NRP2 -45 NA NA NA 6
FGFR1 -44 NA NA NA 134
JUN -26 NA NA NA 47
ANK2 -21 NA -41 198 -22
NCOR1 -18 NA 208 -112 NA
ITGA10 -16 48 -77 10 NA
RPS18 NA 78 NA -118 NA
RPL6 NA 76 NA NA NA
RPL3 NA 75 NA NA NA
RPL32 NA 74 -201 NA NA
RPS4X NA 72 NA NA NA
RPL28 NA 70 NA NA NA
RPL18A NA 68 NA -117 NA
RPL10 NA 66 NA NA NA
RPS14 NA 65 NA NA NA
EZH2 NA -133 NA NA -277
RPL10A NA 63 NA -56 NA
RPL27A NA 61 NA NA NA
RPL15 NA 59 NA NA NA
RPS12 NA 58 NA -87 -417
RPL13 NA 57 NA NA NA
RPL7A NA 55 NA NA NA
PSMB2 NA -92 NA NA NA
RPL39L NA -85 NA NA -223
RPS27 NA 49 NA NA NA
RPL23 NA 47 NA NA NA
RPL26 NA 44 NA NA NA
LEF1 NA 16 NA NA NA
PSMA7 NA NA 206 NA -189
HSP90AB1 NA NA 182 -47 -489
RPL34 NA NA -217 NA NA
COL9A3 NA NA 81 NA -11
RPL29 NA NA -194 NA NA
RPS3A NA NA -190 NA NA
HDAC2 NA NA 64 NA -51
RPL41 NA NA -184 NA NA
MPZ NA NA 47 1 -605
RPS20 NA NA 31 NA NA
CLTB NA NA -173 NA NA
PTPN11 NA NA 11 NA NA
UBC NA NA -146 NA NA
PDLIM7 NA NA -88 NA 42
UBA52 NA NA NA -113 NA
RPS26 NA NA NA 186 NA
CACNG8 NA NA NA 182 339
CRMP1 NA NA NA 170 NA
RPL23A NA NA NA -105 -216
MMP2 NA NA NA -103 NA
TGFB1 NA NA NA -100 NA
SEMA5A NA NA NA 155 NA
PSMB4 NA NA NA 143 NA
AP2S1 NA NA NA 138 NA
RPL14 NA NA NA -89 -203
RPL21 NA NA NA -84 -100
TRIO NA NA NA 113 NA
SCD5 NA NA NA 110 NA
MYO10 NA NA NA 85 NA
RPS10 NA NA NA -46 NA
SHTN1 NA NA NA 43 NA
EZR NA NA NA -18 NA
SOX10 NA NA NA NA -608
RPS19 NA NA NA NA -533
AP2M1 NA NA NA NA 407
RPS16 NA NA NA NA -413
RPS27A NA NA NA NA -410
RPS23 NA NA NA NA -379
RPL8 NA NA NA NA -361
RPLP2 NA NA NA NA -322
PABPC1 NA NA NA NA -318
RPLP1 NA NA NA NA -312
PFN1 NA NA NA NA -289
RPS25 NA NA NA NA -259
H2AFX NA NA NA NA -230
RAC1 NA NA NA NA -213
TLN1 NA NA NA NA 319
ARPC1A NA NA NA NA -205
ETF1 NA NA NA NA -202
TCF4 NA NA NA NA 312
FARP2 NA NA NA NA -146
POLR2I NA NA NA NA -111
RBBP7 NA NA NA NA -101
PSMB3 NA NA NA NA -93
ELOB NA NA NA NA 266
ARPC1B NA NA NA NA -72
SEMA6A NA NA NA NA 254
CDK4 NA NA NA NA -37
ENAH NA NA NA NA 232
FOXP1 NA NA NA NA 230
FYN NA NA NA NA 190
ADAM10 NA NA NA NA 170
PBX1 NA NA NA NA 167
ACTG1 NA NA NA NA 152
SHC1 NA NA NA NA 147
DOK5 NA NA NA NA 129
ROBO1 NA NA NA NA 109
MEF2A NA NA NA NA 87
CTNNB1 NA NA NA NA 82
IRS2 NA NA NA NA 74
FURIN NA NA NA NA 64
CBFB NA NA NA NA 38
SOX2 NA NA NA NA 35
DPYSL2 NA NA NA NA 34
NR2F2 NA NA NA NA 32
COL4A1 NA NA NA NA 10
LPL NA NA NA NA 4





Epigenetic regulation of gene expression

Epigenetic regulation of gene expression
metric value
setSize 14
pMANOVA 5.07e-06
p.adjustMANOVA 2.59e-05
s.dist 0.282
s.clus_0 0.105
s.clus_1 -0.0327
s.clus_2 0.089
s.clus_3 -0.0309
s.clus_4 -0.242
p.clus_0 0.913
p.clus_1 0.000207
p.clus_2 0.044
p.clus_3 0.358
p.clus_4 0.4


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Top 20 genes
Gene clus_4 clus_0
POLR2F -615 302
DDX21 -437 187
POLR2H -284 140
BAZ1B -170 139
DEK -419 50
DNMT1 -219 72

Click HERE to show all gene set members

All member genes
clus_0 clus_1 clus_2 clus_3 clus_4
POLR2F 302 -18 NA NA -615
DDX21 187 NA NA NA -437
POLR1E 149 NA NA NA NA
POLR2H 140 NA NA NA -284
BAZ1B 139 -36 27 NA -170
DNMT1 72 -121 NA NA -219
DEK 50 -200 190 -49 -419
POLR2L -206 NA -143 92 303
EZH2 NA -133 NA NA -277
CBX3 NA NA 183 NA -331
HDAC2 NA NA 64 NA -51
PHF19 NA NA NA NA -554
H2AFX NA NA NA NA -230
RBBP7 NA NA NA NA -101





Gene expression (Transcription)

Gene expression (Transcription)
metric value
setSize 145
pMANOVA 5.07e-06
p.adjustMANOVA 2.59e-05
s.dist 0.207
s.clus_0 0.0746
s.clus_1 -0.0303
s.clus_2 0.0951
s.clus_3 -0.0527
s.clus_4 -0.157
p.clus_0 0.913
p.clus_1 0.000207
p.clus_2 0.044
p.clus_3 0.358
p.clus_4 0.4


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Warning: Removed 122 rows containing non-finite values (stat_density2d).
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Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 138 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 102 rows containing missing values
Warning: Removed 133 rows containing non-finite values (stat_density2d).
Warning: Removed 140 rows containing non-finite values (stat_density2d).
Warning: Removed 138 rows containing non-finite values (stat_density2d).
Warning: Removed 125 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 135 rows containing missing values
Warning: Removed 84 rows containing non-finite values (stat_density2d).
Warning: Removed 101 rows containing non-finite values (stat_density2d).
Warning: Removed 102 rows containing non-finite values (stat_density2d).
Warning: Removed 135 rows containing non-finite values (stat_density2d).
Warning: Removed 32 rows containing non-finite values (stat_bin).

Warning: Removed 67 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 110 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 116 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 133 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 84 rows containing missing values
Warning: Removed 110 rows containing missing values (geom_point).
Warning: Removed 94 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 122 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 140 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 101 rows containing missing values
Warning: Removed 116 rows containing missing values (geom_point).
Warning: Removed 122 rows containing missing values (geom_point).
Warning: Removed 91 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 138 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 102 rows containing missing values
Warning: Removed 133 rows containing missing values (geom_point).
Warning: Removed 140 rows containing missing values (geom_point).
Warning: Removed 138 rows containing missing values (geom_point).
Warning: Removed 125 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 135 rows containing missing values
Warning: Removed 84 rows containing missing values (geom_point).
Warning: Removed 101 rows containing missing values (geom_point).
Warning: Removed 102 rows containing missing values (geom_point).
Warning: Removed 135 rows containing missing values (geom_point).
Warning: Removed 32 rows containing non-finite values (stat_bin).
Warning in grid.Call.graphics(C_points, x$x, x$y, x$pch, x$size): semi-
transparency is not supported on this device: reported only once per page

Warning: Removed 4751 rows containing non-finite values (stat_ydensity).
Warning: Removed 4751 rows containing non-finite values (stat_boxplot).
Warning: Removed 409 rows containing non-finite values (stat_ydensity).
Warning: Removed 409 rows containing non-finite values (stat_boxplot).



Top 20 genes
Gene clus_4 clus_2
RAN -609 207
HSPD1 -610 189
UBE2S -584 194
TPX2 -537 210
NPM1 -611 169
BIRC5 -569 179
SNRPF -548 180
CCNB1 -454 200
PRMT1 -547 165
CYCS -607 137
DEK -419 190
PLD6 -345 201
CBX3 -331 183
GTF3A -523 114
SRSF3 -549 98
FANCI -561 80
PRELID1 -606 74
SNRPE -576 69
PSMA7 -189 206
SNRPD3 -497 77

Click HERE to show all gene set members

All member genes
clus_0 clus_1 clus_2 clus_3 clus_4
SNRPB 381 -166 NA NA -495
RNPS1 368 NA NA -48 -217
MYC 367 -12 NA -60 -492
NDUFA4 -340 NA NA 153 NA
SRSF2 359 -57 NA NA -565
COX6C -337 NA NA 175 NA
TFDP1 353 NA NA NA -254
PARP1 335 -190 34 NA -433
NUP210 332 NA NA NA NA
BID 323 NA NA -70 -317
RRM2 311 -162 NA NA -358
CCNA2 304 -194 5 NA -392
POLR2F 302 -18 NA NA -615
HSPD1 298 -77 189 NA -610
SLBP 291 -69 NA NA -42
SRSF7 290 -79 21 NA -585
POLR3K 287 -72 NA NA -416
RFC4 278 -111 NA NA -211
BIRC5 277 -228 179 NA -569
HSP90AA1 270 -125 NA NA -351
SKP1 -321 NA NA NA NA
SSRP1 251 NA NA NA -385
COX5A 250 NA NA NA -570
POLR3G 224 NA NA NA -476
MAGOHB 219 -71 NA NA -475
SNRPD3 213 NA 77 NA -497
CDK1 208 -150 NA NA -195
PCNA 202 -157 NA NA -303
SMARCA4 198 NA NA NA -54
TFAM 188 NA NA NA -229
DDX21 187 NA NA NA -437
RBM8A 177 NA NA NA -33
APOE -302 NA -59 NA 448
YWHAZ -299 NA NA 147 NA
UBE2S 157 -223 194 NA -584
SRSF3 151 -100 98 NA -549
POLR1E 149 NA NA NA NA
UBE2I 141 NA NA NA -45
POLR2H 140 NA NA NA -284
BAZ1B 139 -36 27 NA -170
SRSF11 137 NA NA NA NA
CYCS 129 -23 137 NA -607
ALYREF 113 -134 NA NA -163
NR2F6 112 NA NA -77 NA
MAGOH 105 NA NA NA -88
RAN 104 NA 207 -37 -609
NOC2L 94 NA NA NA NA
CAV1 -274 6 -72 NA 396
SUPT16H 74 -101 NA NA -127
DNMT1 72 -121 NA NA -219
PRDX2 67 -39 NA NA NA
PCBP4 56 NA NA NA -350
DEK 50 -200 190 -49 -419
SMARCC1 35 NA NA NA -226
TRIM28 34 NA 28 NA -194
PRMT1 33 NA 165 NA -547
DDX39A 31 -132 NA NA NA
CALM1 -244 NA -75 NA 297
PSMA3 23 NA NA NA -105
YWHAB -241 NA 184 NA NA
IGFBP3 -228 73 -4 NA 0
SSU72 9 NA NA NA NA
NPM1 5 NA 169 NA -611
POLR2L -206 NA -143 92 303
ZKSCAN1 -197 40 NA NA NA
CDKN2B -190 23 -23 NA 131
BTG1 -162 62 NA -20 NA
SPP1 -151 NA -22 NA 421
LGALS3 -150 NA -61 NA 299
MAF -128 NA NA NA 290
CCND2 -110 -31 -149 NA 51
TMEM219 -105 NA -107 NA NA
CTGF -91 12 NA NA 14
MEF2C -87 NA -48 NA 351
NR2F1 -54 NA NA NA 294
JUN -26 NA NA NA 47
NCOR1 -18 NA 208 -112 NA
CITED1 -14 1 -2 NA -104
TPX2 NA -224 210 -6 -537
CCNB1 NA -210 200 NA -454
UBE2C NA -196 1 NA -465
MYBL2 NA -180 NA NA -482
FANCI NA -178 80 NA -561
ATAD2 NA -176 NA NA -324
RPA3 NA -144 131 NA -283
SNRPG NA -143 NA NA -225
EZH2 NA -133 NA NA -277
SNRPE NA -118 69 NA -576
LBR NA -116 168 NA -207
AURKA NA -115 104 NA -196
PSMB2 NA -92 NA NA NA
GTF2A2 NA -78 NA 64 -86
NFATC2 NA 35 NA NA NA
LEF1 NA 16 NA NA NA
PSMA7 NA NA 206 NA -189
PLD6 NA NA 201 -57 -345
CBX3 NA NA 183 NA -331
SNRPF NA NA 180 NA -548
GTF3A NA NA 114 -58 -523
SSB NA NA 101 NA -252
MDM2 NA NA 91 NA NA
PRELID1 NA NA 74 NA -606
HDAC2 NA NA 64 NA -51
RAE1 NA NA 63 NA NA
DYRK2 NA NA 26 NA NA
PTPN11 NA NA 11 NA NA
CDK6 NA NA 8 NA NA
UBC NA NA -146 NA NA
RSPO3 NA NA -130 NA NA
GADD45A NA NA -56 NA 156
CCND1 NA NA -30 NA NA
UBA52 NA NA NA -113 NA
COX7C NA NA NA 176 NA
TGFB1 NA NA NA -100 NA
PSMB4 NA NA NA 143 NA
PHF19 NA NA NA NA -554
PRDX1 NA NA NA NA -511
SOCS3 NA NA NA NA 406
TXN NA NA NA NA -503
RPS27A NA NA NA NA -410
HIPK2 NA NA NA NA -279
HEY1 NA NA NA NA 335
H2AFX NA NA NA NA -230
SRSF9 NA NA NA NA -180
GTF2F2 NA NA NA NA -177
THOC7 NA NA NA NA -160
BNIP3L NA NA NA NA 277
POLR2I NA NA NA NA -111
RBBP7 NA NA NA NA -101
PSMB3 NA NA NA NA -93
SMAD1 NA NA NA NA 268
ELOB NA NA NA NA 266
CDK4 NA NA NA NA -37
BBC3 NA NA NA NA 237
CAMK2D NA NA NA NA 212
NR3C1 NA NA NA NA 199
SESN3 NA NA NA NA 182
JUNB NA NA NA NA 165
CTSL NA NA NA NA 102
SGK1 NA NA NA NA 100
CTNNB1 NA NA NA NA 82
PPP2CB NA NA NA NA 70
FOS NA NA NA NA 45
CBFB NA NA NA NA 38
SOX2 NA NA NA NA 35





Generic Transcription Pathway

Generic Transcription Pathway
metric value
setSize 110
pMANOVA 5.07e-06
p.adjustMANOVA 2.59e-05
s.dist 0.114
s.clus_0 -0.0057
s.clus_1 -0.0263
s.clus_2 0.0758
s.clus_3 -0.0362
s.clus_4 -0.0728
p.clus_0 0.913
p.clus_1 0.000207
p.clus_2 0.044
p.clus_3 0.358
p.clus_4 0.4


Warning: Removed 56 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 87 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 86 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 100 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 68 rows containing missing values
Warning: Removed 87 rows containing non-finite values (stat_density2d).
Warning: Removed 74 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 91 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 106 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 80 rows containing missing values
Warning: Removed 86 rows containing non-finite values (stat_density2d).
Warning: Removed 91 rows containing non-finite values (stat_density2d).
Warning: Removed 67 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 106 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 77 rows containing missing values
Warning: Removed 100 rows containing non-finite values (stat_density2d).
Warning: Removed 106 rows containing non-finite values (stat_density2d).

Warning: Removed 106 rows containing non-finite values (stat_density2d).
Warning: Removed 95 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 105 rows containing missing values
Warning: Removed 68 rows containing non-finite values (stat_density2d).
Warning: Removed 80 rows containing non-finite values (stat_density2d).
Warning: Removed 77 rows containing non-finite values (stat_density2d).
Warning: Removed 105 rows containing non-finite values (stat_density2d).
Warning: Removed 26 rows containing non-finite values (stat_bin).

Warning: Removed 56 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 87 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 86 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 100 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 68 rows containing missing values
Warning: Removed 87 rows containing missing values (geom_point).
Warning: Removed 74 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 91 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 106 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 80 rows containing missing values
Warning: Removed 86 rows containing missing values (geom_point).
Warning: Removed 91 rows containing missing values (geom_point).
Warning: Removed 67 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 106 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 77 rows containing missing values
Warning: Removed 100 rows containing missing values (geom_point).
Warning: Removed 106 rows containing missing values (geom_point).

Warning: Removed 106 rows containing missing values (geom_point).
Warning: Removed 95 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 105 rows containing missing values
Warning: Removed 68 rows containing missing values (geom_point).
Warning: Removed 80 rows containing missing values (geom_point).
Warning: Removed 77 rows containing missing values (geom_point).
Warning: Removed 105 rows containing missing values (geom_point).
Warning: Removed 26 rows containing non-finite values (stat_bin).
Warning in grid.Call.graphics(C_points, x$x, x$y, x$pch, x$size): semi-
transparency is not supported on this device: reported only once per page

Warning: Removed 4751 rows containing non-finite values (stat_ydensity).
Warning: Removed 4751 rows containing non-finite values (stat_boxplot).
Warning: Removed 318 rows containing non-finite values (stat_ydensity).
Warning: Removed 318 rows containing non-finite values (stat_boxplot).



Top 20 genes
Gene clus_2 clus_4
HSPD1 189 -610
UBE2S 194 -584
TPX2 210 -537
NPM1 169 -611
BIRC5 179 -569
CCNB1 200 -454
PRMT1 165 -547
CYCS 137 -607
DEK 190 -419
CBX3 183 -331
FANCI 80 -561
PRELID1 74 -606
PSMA7 206 -189
RPA3 131 -283
LBR 168 -207
AURKA 104 -196
PARP1 34 -433
TRIM28 28 -194
HDAC2 64 -51
CCNA2 5 -392

Click HERE to show all gene set members

All member genes
clus_0 clus_1 clus_2 clus_3 clus_4
MYC 367 -12 NA -60 -492
NDUFA4 -340 NA NA 153 NA
COX6C -337 NA NA 175 NA
TFDP1 353 NA NA NA -254
PARP1 335 -190 34 NA -433
BID 323 NA NA -70 -317
RRM2 311 -162 NA NA -358
CCNA2 304 -194 5 NA -392
POLR2F 302 -18 NA NA -615
HSPD1 298 -77 189 NA -610
RFC4 278 -111 NA NA -211
BIRC5 277 -228 179 NA -569
SKP1 -321 NA NA NA NA
SSRP1 251 NA NA NA -385
COX5A 250 NA NA NA -570
CDK1 208 -150 NA NA -195
PCNA 202 -157 NA NA -303
SMARCA4 198 NA NA NA -54
APOE -302 NA -59 NA 448
YWHAZ -299 NA NA 147 NA
UBE2S 157 -223 194 NA -584
UBE2I 141 NA NA NA -45
POLR2H 140 NA NA NA -284
CYCS 129 -23 137 NA -607
NR2F6 112 NA NA -77 NA
NOC2L 94 NA NA NA NA
CAV1 -274 6 -72 NA 396
SUPT16H 74 -101 NA NA -127
PRDX2 67 -39 NA NA NA
PCBP4 56 NA NA NA -350
DEK 50 -200 190 -49 -419
SMARCC1 35 NA NA NA -226
TRIM28 34 NA 28 NA -194
PRMT1 33 NA 165 NA -547
CALM1 -244 NA -75 NA 297
PSMA3 23 NA NA NA -105
YWHAB -241 NA 184 NA NA
IGFBP3 -228 73 -4 NA 0
NPM1 5 NA 169 NA -611
POLR2L -206 NA -143 92 303
ZKSCAN1 -197 40 NA NA NA
CDKN2B -190 23 -23 NA 131
BTG1 -162 62 NA -20 NA
SPP1 -151 NA -22 NA 421
LGALS3 -150 NA -61 NA 299
MAF -128 NA NA NA 290
CCND2 -110 -31 -149 NA 51
TMEM219 -105 NA -107 NA NA
CTGF -91 12 NA NA 14
MEF2C -87 NA -48 NA 351
NR2F1 -54 NA NA NA 294
JUN -26 NA NA NA 47
NCOR1 -18 NA 208 -112 NA
CITED1 -14 1 -2 NA -104
TPX2 NA -224 210 -6 -537
CCNB1 NA -210 200 NA -454
UBE2C NA -196 1 NA -465
MYBL2 NA -180 NA NA -482
FANCI NA -178 80 NA -561
ATAD2 NA -176 NA NA -324
RPA3 NA -144 131 NA -283
EZH2 NA -133 NA NA -277
LBR NA -116 168 NA -207
AURKA NA -115 104 NA -196
PSMB2 NA -92 NA NA NA
NFATC2 NA 35 NA NA NA
LEF1 NA 16 NA NA NA
PSMA7 NA NA 206 NA -189
CBX3 NA NA 183 NA -331
MDM2 NA NA 91 NA NA
PRELID1 NA NA 74 NA -606
HDAC2 NA NA 64 NA -51
DYRK2 NA NA 26 NA NA
PTPN11 NA NA 11 NA NA
CDK6 NA NA 8 NA NA
UBC NA NA -146 NA NA
RSPO3 NA NA -130 NA NA
GADD45A NA NA -56 NA 156
CCND1 NA NA -30 NA NA
UBA52 NA NA NA -113 NA
COX7C NA NA NA 176 NA
TGFB1 NA NA NA -100 NA
PSMB4 NA NA NA 143 NA
PRDX1 NA NA NA NA -511
SOCS3 NA NA NA NA 406
TXN NA NA NA NA -503
RPS27A NA NA NA NA -410
HIPK2 NA NA NA NA -279
HEY1 NA NA NA NA 335
H2AFX NA NA NA NA -230
GTF2F2 NA NA NA NA -177
BNIP3L NA NA NA NA 277
POLR2I NA NA NA NA -111
RBBP7 NA NA NA NA -101
PSMB3 NA NA NA NA -93
SMAD1 NA NA NA NA 268
ELOB NA NA NA NA 266
CDK4 NA NA NA NA -37
BBC3 NA NA NA NA 237
CAMK2D NA NA NA NA 212
NR3C1 NA NA NA NA 199
SESN3 NA NA NA NA 182
JUNB NA NA NA NA 165
CTSL NA NA NA NA 102
SGK1 NA NA NA NA 100
CTNNB1 NA NA NA NA 82
PPP2CB NA NA NA NA 70
FOS NA NA NA NA 45
CBFB NA NA NA NA 38
SOX2 NA NA NA NA 35





Positive epigenetic regulation of rRNA expression

Positive epigenetic regulation of rRNA expression
metric value
setSize 11
pMANOVA 5.07e-06
p.adjustMANOVA 2.59e-05
s.dist 0.252
s.clus_0 0.111
s.clus_1 -0.0101
s.clus_2 0.089
s.clus_3 -0.0309
s.clus_4 -0.205
p.clus_0 0.913
p.clus_1 0.000207
p.clus_2 0.044
p.clus_3 0.358
p.clus_4 0.4


Warning: Removed 4751 rows containing non-finite values (stat_ydensity).
Warning: Removed 4751 rows containing non-finite values (stat_boxplot).
Warning: Removed 28 rows containing non-finite values (stat_ydensity).
Warning: Removed 28 rows containing non-finite values (stat_boxplot).



Top 20 genes
Gene clus_4 clus_0
POLR2F -615 302
DDX21 -437 187
POLR2H -284 140
BAZ1B -170 139
DEK -419 50

Click HERE to show all gene set members

All member genes
clus_0 clus_1 clus_2 clus_3 clus_4
POLR2F 302 -18 NA NA -615
DDX21 187 NA NA NA -437
POLR1E 149 NA NA NA NA
POLR2H 140 NA NA NA -284
BAZ1B 139 -36 27 NA -170
DEK 50 -200 190 -49 -419
POLR2L -206 NA -143 92 303
CBX3 NA NA 183 NA -331
HDAC2 NA NA 64 NA -51
H2AFX NA NA NA NA -230
RBBP7 NA NA NA NA -101





RNA Polymerase II Transcription

RNA Polymerase II Transcription
metric value
setSize 130
pMANOVA 5.07e-06
p.adjustMANOVA 2.59e-05
s.dist 0.162
s.clus_0 0.0482
s.clus_1 -0.0308
s.clus_2 0.0829
s.clus_3 -0.0381
s.clus_4 -0.121
p.clus_0 0.913
p.clus_1 0.000207
p.clus_2 0.044
p.clus_3 0.358
p.clus_4 0.4


Warning: Removed 62 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 99 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 103 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 119 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 77 rows containing missing values
Warning: Removed 99 rows containing non-finite values (stat_density2d).
Warning: Removed 83 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 108 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 125 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 90 rows containing missing values
Warning: Removed 103 rows containing non-finite values (stat_density2d).
Warning: Removed 108 rows containing non-finite values (stat_density2d).
Warning: Removed 82 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 126 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 92 rows containing missing values
Warning: Removed 119 rows containing non-finite values (stat_density2d).
Warning: Removed 125 rows containing non-finite values (stat_density2d).
Warning: Removed 126 rows containing non-finite values (stat_density2d).
Warning: Removed 113 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 123 rows containing missing values
Warning: Removed 77 rows containing non-finite values (stat_density2d).
Warning: Removed 90 rows containing non-finite values (stat_density2d).
Warning: Removed 92 rows containing non-finite values (stat_density2d).
Warning: Removed 123 rows containing non-finite values (stat_density2d).
Warning: Removed 29 rows containing non-finite values (stat_bin).

Warning: Removed 62 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 99 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 103 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 119 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 77 rows containing missing values
Warning: Removed 99 rows containing missing values (geom_point).
Warning: Removed 83 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 108 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 125 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 90 rows containing missing values
Warning: Removed 103 rows containing missing values (geom_point).
Warning: Removed 108 rows containing missing values (geom_point).
Warning: Removed 82 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 126 rows containing missing values
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 92 rows containing missing values
Warning: Removed 119 rows containing missing values (geom_point).
Warning: Removed 125 rows containing missing values (geom_point).
Warning: Removed 126 rows containing missing values (geom_point).
Warning: Removed 113 rows containing non-finite values (stat_bin).
Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 123 rows containing missing values
Warning: Removed 77 rows containing missing values (geom_point).
Warning: Removed 90 rows containing missing values (geom_point).
Warning: Removed 92 rows containing missing values (geom_point).
Warning: Removed 123 rows containing missing values (geom_point).
Warning: Removed 29 rows containing non-finite values (stat_bin).
Warning in grid.Call.graphics(C_points, x$x, x$y, x$pch, x$size): semi-
transparency is not supported on this device: reported only once per page

Warning: Removed 4751 rows containing non-finite values (stat_ydensity).
Warning: Removed 4751 rows containing non-finite values (stat_boxplot).
Warning: Removed 369 rows containing non-finite values (stat_ydensity).
Warning: Removed 369 rows containing non-finite values (stat_boxplot).



Top 20 genes
Gene clus_4 clus_2
HSPD1 -610 189
UBE2S -584 194
TPX2 -537 210
NPM1 -611 169
BIRC5 -569 179
SNRPF -548 180
CCNB1 -454 200
PRMT1 -547 165
CYCS -607 137
DEK -419 190
CBX3 -331 183
SRSF3 -549 98
FANCI -561 80
PRELID1 -606 74
SNRPE -576 69
PSMA7 -189 206
SNRPD3 -497 77
RPA3 -283 131
LBR -207 168
AURKA -196 104

Click HERE to show all gene set members

All member genes
clus_0 clus_1 clus_2 clus_3 clus_4
SNRPB 381 -166 NA NA -495
RNPS1 368 NA NA -48 -217
MYC 367 -12 NA -60 -492
NDUFA4 -340 NA NA 153 NA
SRSF2 359 -57 NA NA -565
COX6C -337 NA NA 175 NA
TFDP1 353 NA NA NA -254
PARP1 335 -190 34 NA -433
BID 323 NA NA -70 -317
RRM2 311 -162 NA NA -358
CCNA2 304 -194 5 NA -392
POLR2F 302 -18 NA NA -615
HSPD1 298 -77 189 NA -610
SLBP 291 -69 NA NA -42
SRSF7 290 -79 21 NA -585
RFC4 278 -111 NA NA -211
BIRC5 277 -228 179 NA -569
SKP1 -321 NA NA NA NA
SSRP1 251 NA NA NA -385
COX5A 250 NA NA NA -570
MAGOHB 219 -71 NA NA -475
SNRPD3 213 NA 77 NA -497
CDK1 208 -150 NA NA -195
PCNA 202 -157 NA NA -303
SMARCA4 198 NA NA NA -54
RBM8A 177 NA NA NA -33
APOE -302 NA -59 NA 448
YWHAZ -299 NA NA 147 NA
UBE2S 157 -223 194 NA -584
SRSF3 151 -100 98 NA -549
UBE2I 141 NA NA NA -45
POLR2H 140 NA NA NA -284
SRSF11 137 NA NA NA NA
CYCS 129 -23 137 NA -607
ALYREF 113 -134 NA NA -163
NR2F6 112 NA NA -77 NA
MAGOH 105 NA NA NA -88
NOC2L 94 NA NA NA NA
CAV1 -274 6 -72 NA 396
SUPT16H 74 -101 NA NA -127
PRDX2 67 -39 NA NA NA
PCBP4 56 NA NA NA -350
DEK 50 -200 190 -49 -419
SMARCC1 35 NA NA NA -226
TRIM28 34 NA 28 NA -194
PRMT1 33 NA 165 NA -547
DDX39A 31 -132 NA NA NA
CALM1 -244 NA -75 NA 297
PSMA3 23 NA NA NA -105
YWHAB -241 NA 184 NA NA
IGFBP3 -228 73 -4 NA 0
SSU72 9 NA NA NA NA
NPM1 5 NA 169 NA -611
POLR2L -206 NA -143 92 303
ZKSCAN1 -197 40 NA NA NA
CDKN2B -190 23 -23 NA 131
BTG1 -162 62 NA -20 NA
SPP1 -151 NA -22 NA 421
LGALS3 -150 NA -61 NA 299
MAF -128 NA NA NA 290
CCND2 -110 -31 -149 NA 51
TMEM219 -105 NA -107 NA NA
CTGF -91 12 NA NA 14
MEF2C -87 NA -48 NA 351
NR2F1 -54 NA NA NA 294
JUN -26 NA NA NA 47
NCOR1 -18 NA 208 -112 NA
CITED1 -14 1 -2 NA -104
TPX2 NA -224 210 -6 -537
CCNB1 NA -210 200 NA -454
UBE2C NA -196 1 NA -465
MYBL2 NA -180 NA NA -482
FANCI NA -178 80 NA -561
ATAD2 NA -176 NA NA -324
RPA3 NA -144 131 NA -283
SNRPG NA -143 NA NA -225
EZH2 NA -133 NA NA -277
SNRPE NA -118 69 NA -576
LBR NA -116 168 NA -207
AURKA NA -115 104 NA -196
PSMB2 NA -92 NA NA NA
GTF2A2 NA -78 NA 64 -86
NFATC2 NA 35 NA NA NA
LEF1 NA 16 NA NA NA
PSMA7 NA NA 206 NA -189
CBX3 NA NA 183 NA -331
SNRPF NA NA 180 NA -548
MDM2 NA NA 91 NA NA
PRELID1 NA NA 74 NA -606
HDAC2 NA NA 64 NA -51
DYRK2 NA NA 26 NA NA
PTPN11 NA NA 11 NA NA
CDK6 NA NA 8 NA NA
UBC NA NA -146 NA NA
RSPO3 NA NA -130 NA NA
GADD45A NA NA -56 NA 156
CCND1 NA NA -30 NA NA
UBA52 NA NA NA -113 NA
COX7C NA NA NA 176 NA
TGFB1 NA NA NA -100 NA
PSMB4 NA NA NA 143 NA
PRDX1 NA NA NA NA -511
SOCS3 NA NA NA NA 406
TXN NA NA NA NA -503
RPS27A NA NA NA NA -410
HIPK2 NA NA NA NA -279
HEY1 NA NA NA NA 335
H2AFX NA NA NA NA -230
SRSF9 NA NA NA NA -180
GTF2F2 NA NA NA NA -177
THOC7 NA NA NA NA -160
BNIP3L NA NA NA NA 277
POLR2I NA NA NA NA -111
RBBP7 NA NA NA NA -101
PSMB3 NA NA NA NA -93
SMAD1 NA NA NA NA 268
ELOB NA NA NA NA 266
CDK4 NA NA NA NA -37
BBC3 NA NA NA NA 237
CAMK2D NA NA NA NA 212
NR3C1 NA NA NA NA 199
SESN3 NA NA NA NA 182
JUNB NA NA NA NA 165
CTSL NA NA NA NA 102
SGK1 NA NA NA NA 100
CTNNB1 NA NA NA NA 82
PPP2CB NA NA NA NA 70
FOS NA NA NA NA 45
CBFB NA NA NA NA 38
SOX2 NA NA NA NA 35





Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
metric value
setSize 9
pMANOVA 5.07e-06
p.adjustMANOVA 2.59e-05
s.dist 0.349
s.clus_0 0.0698
s.clus_1 -0.0405
s.clus_2 0.133
s.clus_3 -0.131
s.clus_4 -0.284
p.clus_0 0.913
p.clus_1 0.000207
p.clus_2 0.044
p.clus_3 0.358
p.clus_4 0.4


Warning: Removed 4751 rows containing non-finite values (stat_ydensity).
Warning: Removed 4751 rows containing non-finite values (stat_boxplot).
Warning: Removed 16 rows containing non-finite values (stat_ydensity).
Warning: Removed 16 rows containing non-finite values (stat_boxplot).



Top 20 genes
Gene clus_4 clus_2
HSPD1 -610 189
NPM1 -611 169
DEK -419 190

Click HERE to show all gene set members

All member genes
clus_0 clus_1 clus_2 clus_3 clus_4
MYC 367 -12 NA -60 -492
HSPD1 298 -77 189 NA -610
APOE -302 NA -59 NA 448
UBE2I 141 NA NA NA -45
DEK 50 -200 190 -49 -419
NPM1 5 NA 169 NA -611
CITED1 -14 1 -2 NA -104
MYBL2 NA -180 NA NA -482
ATAD2 NA -176 NA NA -324





Transcriptional regulation of granulopoiesis

Transcriptional regulation of granulopoiesis
metric value
setSize 7
pMANOVA 5.07e-06
p.adjustMANOVA 2.59e-05
s.dist 0.464
s.clus_0 0.304
s.clus_1 0.0154
s.clus_2 0.253
s.clus_3 -0.131
s.clus_4 -0.203
p.clus_0 0.913
p.clus_1 0.000207
p.clus_2 0.044
p.clus_3 0.358
p.clus_4 0.4


Warning: Removed 4751 rows containing non-finite values (stat_ydensity).
Warning: Removed 4751 rows containing non-finite values (stat_boxplot).
Warning: Removed 20 rows containing non-finite values (stat_ydensity).
Warning: Removed 20 rows containing non-finite values (stat_boxplot).



Top 20 genes
Gene clus_0 clus_2
DEK 50 190

Click HERE to show all gene set members

All member genes
clus_0 clus_1 clus_2 clus_3 clus_4
MYC 367 -12 NA -60 -492
TFDP1 353 NA NA NA -254
DEK 50 -200 190 -49 -419
LEF1 NA 16 NA NA NA
H2AFX NA NA NA NA -230
CDK4 NA NA NA NA -37
CBFB NA NA NA NA 38





IRE1alpha activates chaperones

IRE1alpha activates chaperones
metric value
setSize 9
pMANOVA 0.0807
p.adjustMANOVA 0.309
s.dist 0.229
s.clus_0 0.073
s.clus_1 0.0441
s.clus_2 0.101
s.clus_3 -0.097
s.clus_4 0.16
p.clus_0 0.222
p.clus_1 0.205
p.clus_2 0.415
p.clus_3 0.249
p.clus_4 0.863


Warning: Removed 4751 rows containing non-finite values (stat_ydensity).
Warning: Removed 4751 rows containing non-finite values (stat_boxplot).
Warning: Removed 27 rows containing non-finite values (stat_ydensity).
Warning: Removed 27 rows containing non-finite values (stat_boxplot).



Top 20 genes
Gene clus_4 clus_2

Click HERE to show all gene set members

All member genes
clus_0 clus_1 clus_2 clus_3 clus_4
HDGF 297 -95 73 -65 -13
KDELR3 175 NA NA -99 -457
LMNA -77 8 NA -16 NA
ACADVL -73 NA NA NA 183
SSR1 NA NA 75 NA NA
DNAJC3 NA NA NA 67 NA
TLN1 NA NA NA NA 319
SHC1 NA NA NA NA 147
ADD1 NA NA NA NA 84





Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.0 (2020-04-24)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
## 
## Matrix products: default
## BLAS:   /mnt/md0/app/R-4.0.0/lib/libRblas.so
## LAPACK: /mnt/md0/app/R-4.0.0/lib/libRlapack.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  grid      stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] mitch_1.1.8     plyr_1.8.6      pbmcapply_1.5.0 knitr_1.30     
##  [5] rmarkdown_2.4   pkgload_1.1.0   beeswarm_0.2.3  gtools_3.8.2   
##  [9] tibble_3.0.3    dplyr_1.0.2     echarts4r_0.3.2 magrittr_1.5   
## [13] reshape2_1.4.4  MASS_7.3-53     gplots_3.1.0    gridExtra_2.3  
## [17] GGally_2.0.0    ggplot2_3.3.2  
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.5         prettyunits_1.1.1  assertthat_0.2.1   rprojroot_1.3-2   
##  [5] digest_0.6.25      mime_0.9           R6_2.4.1           backports_1.1.10  
##  [9] evaluate_0.14      highr_0.8          pillar_1.4.6       rlang_0.4.7       
## [13] progress_1.2.2     desc_1.2.0         labeling_0.3       stringr_1.4.0     
## [17] htmlwidgets_1.5.2  munsell_0.5.0      shiny_1.5.0        compiler_4.0.0    
## [21] httpuv_1.5.4       xfun_0.18          pkgconfig_2.0.3    htmltools_0.5.0   
## [25] tidyselect_1.1.0   reshape_0.8.8      crayon_1.3.4       withr_2.3.0       
## [29] later_1.1.0.1      bitops_1.0-6       jsonlite_1.7.1     xtable_1.8-4      
## [33] gtable_0.3.0       lifecycle_0.2.0    scales_1.1.1       KernSmooth_2.23-17
## [37] stringi_1.5.3      farver_2.0.3       promises_1.1.1     testthat_2.3.2    
## [41] ellipsis_0.3.1     generics_0.0.2     vctrs_0.3.4        RColorBrewer_1.1-2
## [45] tools_4.0.0        glue_1.4.2         purrr_0.3.4        hms_0.5.3         
## [49] fastmap_1.0.1      yaml_2.2.1         colorspace_1.4-1   caTools_1.18.0

END of report