date generated: 2020-07-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    young        old
## 0610009B22Rik -2.9385024 -6.1805927
## 0610009E02Rik  0.6410018 -1.6821055
## 0610009L18Rik -4.5856767 -3.1288917
## 0610010F05Rik  0.6483013  0.4402823
## 0610010K14Rik -8.7879236 -3.0864256
## 0610012G03Rik -8.7415080 -6.4223694

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 14877
duplicated_genes_present 0
num_profile_genes_in_sets 7299
num_profile_genes_not_in_sets 7578
profile_pearson_correl 0.8374
profile_spearman_correl 0.80977

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ../ref/ReactomePathways_mouse.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2302
num_genesets_excluded 1023
num_genesets_included 1279

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 245

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.young s.old p.young p.old
Formation-of-ATP-by-chemiosmotic-coupling 16 1.29e-10 4.72e-09 1.310 -0.933 -0.919 1.02e-10 1.89e-10
Complex-I-biogenesis 54 1.62e-33 2.07e-31 1.300 -0.930 -0.904 2.28e-32 1.25e-30
Citric-acid-cycle-(TCA-cycle) 22 2.51e-13 1.53e-11 1.260 -0.894 -0.889 3.71e-13 5.02e-13
Cristae-formation 29 4.27e-17 3.22e-15 1.250 -0.905 -0.861 3.21e-17 9.79e-16
Respiratory-electron-transport 100 4.63e-57 1.97e-54 1.250 -0.904 -0.859 2.80e-55 4.76e-50
Branched-chain-amino-acid-catabolism 19 5.85e-11 2.49e-09 1.220 -0.859 -0.871 9.04e-11 4.89e-11
Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins. 120 4.61e-65 2.95e-62 1.220 -0.883 -0.836 5.28e-63 1.12e-56
Mitochondrial-Fatty-Acid-Beta-Oxidation 31 5.13e-17 3.65e-15 1.210 -0.858 -0.850 1.25e-16 2.49e-16
The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport 167 1.25e-82 1.60e-79 1.170 -0.835 -0.813 5.14e-78 5.46e-74
rRNA-processing-in-the-mitochondrion 22 1.56e-11 7.41e-10 1.160 -0.783 -0.854 2.00e-10 3.93e-12
tRNA-processing-in-the-mitochondrion 18 3.43e-09 1.18e-07 1.130 -0.750 -0.842 3.52e-08 6.26e-10
Mitochondrial-translation-elongation 88 2.90e-41 6.18e-39 1.120 -0.827 -0.758 3.38e-41 8.11e-35
Mitochondrial-translation 94 6.95e-44 1.78e-41 1.120 -0.825 -0.758 1.11e-43 4.24e-37
Mitochondrial-translation-termination 88 4.51e-41 8.23e-39 1.120 -0.825 -0.756 5.15e-41 1.18e-34
Mitochondrial-translation-initiation 88 1.35e-40 2.16e-38 1.110 -0.821 -0.750 1.25e-40 4.30e-34
Mitochondrial-iron-sulfur-cluster-biogenesis 10 6.99e-05 9.35e-04 1.070 -0.741 -0.775 4.95e-05 2.19e-05
Glyoxylate-metabolism-and-glycine-degradation 25 7.78e-11 3.12e-09 1.060 -0.751 -0.748 7.74e-11 9.53e-11
Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle 51 4.48e-21 4.10e-19 1.050 -0.725 -0.760 3.15e-19 5.37e-21
Collagen-chain-trimerization 33 1.12e-13 7.15e-12 1.040 0.737 0.740 2.34e-13 1.79e-13
Mitochondrial-tRNA-aminoacylation 19 3.66e-08 1.06e-06 1.040 -0.756 -0.712 1.14e-08 7.59e-08
Mitochondrial-protein-import 57 8.67e-23 8.53e-21 1.030 -0.762 -0.686 2.29e-23 2.95e-19
Metabolism-of-cofactors 18 6.03e-07 1.40e-05 0.979 -0.703 -0.681 2.41e-07 5.56e-07
Keratan-sulfate-degradation 10 6.99e-04 5.96e-03 0.932 0.680 0.638 1.95e-04 4.80e-04
CS/DS-degradation 11 3.22e-04 3.17e-03 0.928 0.620 0.691 3.74e-04 7.28e-05
Collagen-biosynthesis-and-modifying-enzymes 56 1.44e-17 1.15e-15 0.914 0.637 0.655 1.59e-16 2.10e-17
Regulation-of-pyruvate-dehydrogenase-(PDH)-complex 15 2.55e-05 4.24e-04 0.914 -0.615 -0.676 3.77e-05 5.76e-06
Crosslinking-of-collagen-fibrils 10 8.72e-04 7.29e-03 0.887 0.685 0.563 1.75e-04 2.06e-03
ECM-proteoglycans 43 3.42e-13 1.90e-11 0.886 0.661 0.590 6.20e-14 2.23e-11
tRNA-Aminoacylation 26 4.87e-08 1.35e-06 0.870 -0.652 -0.576 8.49e-09 3.70e-07
Chondroitin-sulfate-biosynthesis 16 4.32e-05 6.35e-04 0.870 0.625 0.605 1.52e-05 2.75e-05
Triglyceride-catabolism 15 9.29e-06 1.75e-04 0.868 -0.503 -0.708 7.41e-04 2.07e-06
Heme-biosynthesis 12 5.39e-04 4.76e-03 0.868 -0.601 -0.627 3.12e-04 1.70e-04
Elastic-fibre-formation 38 7.80e-11 3.12e-09 0.860 0.608 0.608 8.52e-11 8.68e-11
Pyruvate-metabolism 27 5.41e-08 1.47e-06 0.853 -0.567 -0.637 3.40e-07 9.95e-09
Defects-in-cobalamin-(B12)-metabolism 12 1.10e-03 8.65e-03 0.823 -0.562 -0.602 7.53e-04 3.04e-04
Mitochondrial-biogenesis 88 1.70e-19 1.45e-17 0.769 -0.530 -0.557 7.78e-18 1.67e-19
Collagen-formation 75 1.22e-16 8.24e-15 0.769 0.546 0.542 3.06e-16 4.96e-16
Assembly-of-collagen-fibrils-and-other-multimeric-structures 46 8.17e-11 3.17e-09 0.769 0.576 0.509 1.34e-11 2.38e-09
Carnitine-metabolism 12 1.61e-03 1.21e-02 0.764 -0.476 -0.598 4.31e-03 3.37e-04
Syndecan-interactions 20 7.01e-05 9.35e-04 0.759 0.544 0.529 2.50e-05 4.16e-05
Molecules-associated-with-elastic-fibres 28 1.45e-06 2.98e-05 0.758 0.516 0.554 2.25e-06 3.82e-07
MET-activates-PTK2-signaling 17 1.25e-04 1.50e-03 0.749 0.593 0.458 2.33e-05 1.08e-03
Protein-localization 142 7.41e-29 7.90e-27 0.742 -0.512 -0.537 6.06e-26 2.04e-28
Prolactin-receptor-signaling 11 5.73e-03 3.32e-02 0.731 -0.472 -0.559 6.73e-03 1.34e-03
Peroxisomal-protein-import 53 2.97e-12 1.52e-10 0.729 -0.446 -0.577 1.95e-08 3.55e-13
Mitochondrial-calcium-ion-transport 21 1.53e-04 1.76e-03 0.710 -0.495 -0.509 8.64e-05 5.32e-05
Chondroitin-sulfate/dermatan-sulfate-metabolism 42 1.03e-08 3.30e-07 0.707 0.540 0.456 1.42e-09 3.11e-07
p130Cas-linkage-to-MAPK-signaling-for-integrins 14 1.95e-03 1.38e-02 0.704 0.545 0.446 4.11e-04 3.88e-03
Defects-in-vitamin-and-cofactor-metabolism 20 1.95e-04 2.08e-03 0.699 -0.452 -0.533 4.61e-04 3.72e-05
Laminin-interactions 22 5.04e-05 7.24e-04 0.698 0.548 0.433 8.72e-06 4.33e-04


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.young s.old p.young p.old
Formation-of-ATP-by-chemiosmotic-coupling 16 1.29e-10 4.72e-09 1.31000 -0.933000 -9.19e-01 1.02e-10 1.89e-10
Complex-I-biogenesis 54 1.62e-33 2.07e-31 1.30000 -0.930000 -9.04e-01 2.28e-32 1.25e-30
Citric-acid-cycle-(TCA-cycle) 22 2.51e-13 1.53e-11 1.26000 -0.894000 -8.89e-01 3.71e-13 5.02e-13
Cristae-formation 29 4.27e-17 3.22e-15 1.25000 -0.905000 -8.61e-01 3.21e-17 9.79e-16
Respiratory-electron-transport 100 4.63e-57 1.97e-54 1.25000 -0.904000 -8.59e-01 2.80e-55 4.76e-50
Branched-chain-amino-acid-catabolism 19 5.85e-11 2.49e-09 1.22000 -0.859000 -8.71e-01 9.04e-11 4.89e-11
Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins. 120 4.61e-65 2.95e-62 1.22000 -0.883000 -8.36e-01 5.28e-63 1.12e-56
Mitochondrial-Fatty-Acid-Beta-Oxidation 31 5.13e-17 3.65e-15 1.21000 -0.858000 -8.50e-01 1.25e-16 2.49e-16
The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport 167 1.25e-82 1.60e-79 1.17000 -0.835000 -8.13e-01 5.14e-78 5.46e-74
rRNA-processing-in-the-mitochondrion 22 1.56e-11 7.41e-10 1.16000 -0.783000 -8.54e-01 2.00e-10 3.93e-12
tRNA-processing-in-the-mitochondrion 18 3.43e-09 1.18e-07 1.13000 -0.750000 -8.42e-01 3.52e-08 6.26e-10
Mitochondrial-translation-elongation 88 2.90e-41 6.18e-39 1.12000 -0.827000 -7.58e-01 3.38e-41 8.11e-35
Mitochondrial-translation 94 6.95e-44 1.78e-41 1.12000 -0.825000 -7.58e-01 1.11e-43 4.24e-37
Mitochondrial-translation-termination 88 4.51e-41 8.23e-39 1.12000 -0.825000 -7.56e-01 5.15e-41 1.18e-34
Mitochondrial-translation-initiation 88 1.35e-40 2.16e-38 1.11000 -0.821000 -7.50e-01 1.25e-40 4.30e-34
Mitochondrial-iron-sulfur-cluster-biogenesis 10 6.99e-05 9.35e-04 1.07000 -0.741000 -7.75e-01 4.95e-05 2.19e-05
Glyoxylate-metabolism-and-glycine-degradation 25 7.78e-11 3.12e-09 1.06000 -0.751000 -7.48e-01 7.74e-11 9.53e-11
Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle 51 4.48e-21 4.10e-19 1.05000 -0.725000 -7.60e-01 3.15e-19 5.37e-21
Collagen-chain-trimerization 33 1.12e-13 7.15e-12 1.04000 0.737000 7.40e-01 2.34e-13 1.79e-13
Mitochondrial-tRNA-aminoacylation 19 3.66e-08 1.06e-06 1.04000 -0.756000 -7.12e-01 1.14e-08 7.59e-08
Mitochondrial-protein-import 57 8.67e-23 8.53e-21 1.03000 -0.762000 -6.86e-01 2.29e-23 2.95e-19
Metabolism-of-cofactors 18 6.03e-07 1.40e-05 0.97900 -0.703000 -6.81e-01 2.41e-07 5.56e-07
Keratan-sulfate-degradation 10 6.99e-04 5.96e-03 0.93200 0.680000 6.38e-01 1.95e-04 4.80e-04
CS/DS-degradation 11 3.22e-04 3.17e-03 0.92800 0.620000 6.91e-01 3.74e-04 7.28e-05
Collagen-biosynthesis-and-modifying-enzymes 56 1.44e-17 1.15e-15 0.91400 0.637000 6.55e-01 1.59e-16 2.10e-17
Regulation-of-pyruvate-dehydrogenase-(PDH)-complex 15 2.55e-05 4.24e-04 0.91400 -0.615000 -6.76e-01 3.77e-05 5.76e-06
Crosslinking-of-collagen-fibrils 10 8.72e-04 7.29e-03 0.88700 0.685000 5.63e-01 1.75e-04 2.06e-03
ECM-proteoglycans 43 3.42e-13 1.90e-11 0.88600 0.661000 5.90e-01 6.20e-14 2.23e-11
tRNA-Aminoacylation 26 4.87e-08 1.35e-06 0.87000 -0.652000 -5.76e-01 8.49e-09 3.70e-07
Chondroitin-sulfate-biosynthesis 16 4.32e-05 6.35e-04 0.87000 0.625000 6.05e-01 1.52e-05 2.75e-05
Triglyceride-catabolism 15 9.29e-06 1.75e-04 0.86800 -0.503000 -7.08e-01 7.41e-04 2.07e-06
Heme-biosynthesis 12 5.39e-04 4.76e-03 0.86800 -0.601000 -6.27e-01 3.12e-04 1.70e-04
Elastic-fibre-formation 38 7.80e-11 3.12e-09 0.86000 0.608000 6.08e-01 8.52e-11 8.68e-11
Pyruvate-metabolism 27 5.41e-08 1.47e-06 0.85300 -0.567000 -6.37e-01 3.40e-07 9.95e-09
Defects-in-cobalamin-(B12)-metabolism 12 1.10e-03 8.65e-03 0.82300 -0.562000 -6.02e-01 7.53e-04 3.04e-04
Mitochondrial-biogenesis 88 1.70e-19 1.45e-17 0.76900 -0.530000 -5.57e-01 7.78e-18 1.67e-19
Collagen-formation 75 1.22e-16 8.24e-15 0.76900 0.546000 5.42e-01 3.06e-16 4.96e-16
Assembly-of-collagen-fibrils-and-other-multimeric-structures 46 8.17e-11 3.17e-09 0.76900 0.576000 5.09e-01 1.34e-11 2.38e-09
Carnitine-metabolism 12 1.61e-03 1.21e-02 0.76400 -0.476000 -5.98e-01 4.31e-03 3.37e-04
Syndecan-interactions 20 7.01e-05 9.35e-04 0.75900 0.544000 5.29e-01 2.50e-05 4.16e-05
Molecules-associated-with-elastic-fibres 28 1.45e-06 2.98e-05 0.75800 0.516000 5.54e-01 2.25e-06 3.82e-07
MET-activates-PTK2-signaling 17 1.25e-04 1.50e-03 0.74900 0.593000 4.58e-01 2.33e-05 1.08e-03
Protein-localization 142 7.41e-29 7.90e-27 0.74200 -0.512000 -5.37e-01 6.06e-26 2.04e-28
Prolactin-receptor-signaling 11 5.73e-03 3.32e-02 0.73100 -0.472000 -5.59e-01 6.73e-03 1.34e-03
Peroxisomal-protein-import 53 2.97e-12 1.52e-10 0.72900 -0.446000 -5.77e-01 1.95e-08 3.55e-13
Mitochondrial-calcium-ion-transport 21 1.53e-04 1.76e-03 0.71000 -0.495000 -5.09e-01 8.64e-05 5.32e-05
Chondroitin-sulfate/dermatan-sulfate-metabolism 42 1.03e-08 3.30e-07 0.70700 0.540000 4.56e-01 1.42e-09 3.11e-07
p130Cas-linkage-to-MAPK-signaling-for-integrins 14 1.95e-03 1.38e-02 0.70400 0.545000 4.46e-01 4.11e-04 3.88e-03
Defects-in-vitamin-and-cofactor-metabolism 20 1.95e-04 2.08e-03 0.69900 -0.452000 -5.33e-01 4.61e-04 3.72e-05
Laminin-interactions 22 5.04e-05 7.24e-04 0.69800 0.548000 4.33e-01 8.72e-06 4.33e-04
Sulfur-amino-acid-metabolism 20 3.47e-04 3.35e-03 0.69100 -0.475000 -5.02e-01 2.39e-04 1.00e-04
Peroxisomal-lipid-metabolism 22 3.71e-05 5.65e-04 0.68700 -0.409000 -5.52e-01 9.02e-04 7.27e-06
Triglyceride-metabolism 22 6.65e-05 9.17e-04 0.68400 -0.420000 -5.39e-01 6.50e-04 1.19e-05
Extracellular-matrix-organization 228 1.35e-38 1.92e-36 0.67700 0.499000 4.58e-01 1.41e-38 1.08e-32
TNF-receptor-superfamily-(TNFSF)-members-mediating-non-canonical-NF-kB-pathway 11 1.67e-02 7.30e-02 0.66500 0.491000 4.48e-01 4.83e-03 1.01e-02
Class-I-peroxisomal-membrane-protein-import 19 1.70e-04 1.90e-03 0.66000 -0.377000 -5.42e-01 4.41e-03 4.30e-05
Cobalamin-(Cbl,-vitamin-B12)-transport-and-metabolism 13 8.93e-03 4.73e-02 0.65900 -0.450000 -4.81e-01 4.98e-03 2.66e-03
Defective-B3GALT6-causes-EDSP2-and-SEMDJL1 16 2.19e-03 1.51e-02 0.64400 0.505000 4.00e-01 4.69e-04 5.66e-03
Gluconeogenesis 26 9.45e-05 1.18e-03 0.64000 -0.417000 -4.86e-01 2.36e-04 1.78e-05
Hyaluronan-uptake-and-degradation 11 2.47e-02 9.95e-02 0.63400 0.431000 4.64e-01 1.32e-02 7.70e-03
Diseases-associated-with-glycosaminoglycan-metabolism 34 7.91e-06 1.51e-04 0.62800 0.479000 4.06e-01 1.31e-06 4.26e-05
Transcriptional-activation-of-mitochondrial-biogenesis 51 3.86e-08 1.10e-06 0.62800 -0.418000 -4.68e-01 2.43e-07 7.23e-09
Mucopolysaccharidoses 11 1.94e-02 8.18e-02 0.62400 0.489000 3.88e-01 4.99e-03 2.60e-02
Pink/Parkin-Mediated-Mitophagy 20 1.23e-03 9.40e-03 0.61600 -0.473000 -3.94e-01 2.54e-04 2.26e-03
Non-integrin-membrane-ECM-interactions 41 1.74e-06 3.49e-05 0.61500 0.461000 4.06e-01 3.18e-07 6.74e-06
TNFs-bind-their-physiological-receptors 12 6.81e-03 3.84e-02 0.60900 0.334000 5.09e-01 4.52e-02 2.25e-03
The-canonical-retinoid-cycle-in-rods-(twilight-vision) 12 4.09e-04 3.79e-03 0.60900 0.245000 5.57e-01 1.41e-01 8.31e-04
Aflatoxin-activation-and-detoxification 10 3.02e-02 1.14e-01 0.60700 -0.369000 -4.82e-01 4.34e-02 8.32e-03
Integrin-cell-surface-interactions 53 1.23e-07 3.14e-06 0.60200 0.430000 4.21e-01 5.95e-08 1.12e-07
Collagen-degradation 26 1.57e-04 1.78e-03 0.60000 0.473000 3.68e-01 2.93e-05 1.17e-03
Activation-of-SMO 15 6.16e-03 3.52e-02 0.59700 0.362000 4.74e-01 1.52e-02 1.47e-03
Translation 241 4.00e-31 4.66e-29 0.59500 -0.415000 -4.26e-01 1.35e-28 4.55e-30
GRB2:SOS-provides-linkage-to-MAPK-signaling-for-Integrins 14 9.96e-03 5.17e-02 0.58800 0.467000 3.57e-01 2.47e-03 2.06e-02
MET-promotes-cell-motility 27 4.01e-05 5.96e-04 0.58800 0.488000 3.29e-01 1.16e-05 3.08e-03
Defective-B3GAT3-causes-JDSSDHD 16 5.53e-03 3.25e-02 0.58600 0.464000 3.57e-01 1.30e-03 1.34e-02
Mitophagy 27 4.58e-04 4.17e-03 0.58200 -0.429000 -3.94e-01 1.16e-04 3.92e-04
Processing-of-SMDT1 15 1.32e-02 6.27e-02 0.58100 -0.385000 -4.35e-01 9.78e-03 3.54e-03
Negative-regulation-of-TCF-dependent-signaling-by-WNT-ligand-antagonists 10 6.05e-02 1.88e-01 0.57100 0.430000 3.76e-01 1.85e-02 3.96e-02
Defective-B4GALT7-causes-EDS,-progeroid-type 16 5.72e-03 3.32e-02 0.57100 0.460000 3.38e-01 1.44e-03 1.94e-02
Unwinding-of-DNA 12 1.08e-02 5.44e-02 0.55600 0.289000 4.75e-01 8.30e-02 4.40e-03
Glycosaminoglycan-metabolism 99 1.18e-12 6.29e-11 0.55100 0.431000 3.43e-01 1.26e-13 3.57e-09
Heparan-sulfate/heparin-(HS-GAG)-metabolism 42 1.75e-07 4.23e-06 0.55100 0.471000 2.87e-01 1.31e-07 1.31e-03
Metabolism-of-porphyrins 19 5.53e-03 3.25e-02 0.55100 -0.348000 -4.27e-01 8.69e-03 1.26e-03
mTORC1-mediated-signalling 20 5.39e-03 3.22e-02 0.55000 -0.361000 -4.15e-01 5.17e-03 1.30e-03
A-tetrasaccharide-linker-sequence-is-required-for-GAG-synthesis 21 1.81e-03 1.31e-02 0.55000 0.444000 3.24e-01 4.28e-04 1.01e-02
O-glycosylation-of-TSR-domain-containing-proteins 33 1.99e-04 2.10e-03 0.54400 0.414000 3.52e-01 3.79e-05 4.70e-04
Hyaluronan-metabolism 15 1.41e-02 6.49e-02 0.54300 0.327000 4.33e-01 2.84e-02 3.66e-03
Biotin-transport-and-metabolism 11 4.41e-02 1.53e-01 0.53900 -0.322000 -4.32e-01 6.47e-02 1.30e-02
Defective-B3GALTL-causes-Peters-plus-syndrome-(PpS) 32 4.00e-04 3.74e-03 0.53500 0.401000 3.55e-01 8.77e-05 5.08e-04
Degradation-of-the-extracellular-matrix 74 5.69e-11 2.49e-09 0.53100 0.445000 2.89e-01 3.56e-11 1.80e-05
HS-GAG-degradation 18 4.70e-04 4.23e-03 0.52600 0.471000 2.34e-01 5.46e-04 8.52e-02
Regulation-of-Insulin-like-Growth-Factor-(IGF)-transport-and-uptake-by-Insulin-like-Growth-Factor-Binding-Proteins-(IGFBPs) 84 4.05e-09 1.36e-07 0.52100 0.389000 3.47e-01 7.59e-10 3.74e-08
Receptor-Mediated-Mitophagy 11 6.92e-02 2.04e-01 0.51900 -0.328000 -4.02e-01 5.94e-02 2.08e-02
Post-translational-protein-phosphorylation 77 2.65e-08 7.88e-07 0.51800 0.385000 3.48e-01 5.49e-09 1.34e-07
Activation-of-Matrix-Metalloproteinases 17 1.06e-02 5.40e-02 0.51300 0.417000 2.98e-01 2.91e-03 3.33e-02
Glutamate-Neurotransmitter-Release-Cycle 18 7.24e-03 4.01e-02 0.51100 0.292000 4.20e-01 3.19e-02 2.05e-03
NOTCH2-intracellular-domain-regulates-transcription 10 8.33e-02 2.32e-01 0.50700 0.305000 4.05e-01 9.46e-02 2.65e-02
Caspase-mediated-cleavage-of-cytoskeletal-proteins 12 6.93e-02 2.04e-01 0.50100 0.385000 3.22e-01 2.10e-02 5.38e-02
Keratan-sulfate/keratin-metabolism 27 3.04e-03 1.95e-02 0.50000 0.376000 3.29e-01 7.15e-04 3.07e-03
The-NLRP3-inflammasome 14 5.13e-02 1.70e-01 0.49700 0.328000 3.74e-01 3.35e-02 1.55e-02
WNT5A-dependent-internalization-of-FZD2,-FZD5-and-ROR2 13 5.29e-03 3.18e-02 0.49200 0.446000 2.06e-01 5.33e-03 1.98e-01
Kinesins 35 8.36e-04 7.04e-03 0.48800 0.364000 3.25e-01 1.92e-04 8.91e-04
Signaling-by-Hippo 20 1.54e-02 6.89e-02 0.48400 0.373000 3.09e-01 3.88e-03 1.67e-02
Glycogen-breakdown-(glycogenolysis) 14 6.48e-02 1.95e-01 0.48400 -0.352000 -3.32e-01 2.24e-02 3.17e-02
Signaling-by-BMP 18 3.07e-02 1.16e-01 0.48000 0.325000 3.53e-01 1.69e-02 9.49e-03
Defective-EXT1-causes-exostoses-1,-TRPS2-and-CHDS 12 1.31e-02 6.22e-02 0.47700 0.430000 2.08e-01 9.98e-03 2.12e-01
Defective-EXT2-causes-exostoses-2 12 1.31e-02 6.22e-02 0.47700 0.430000 2.08e-01 9.98e-03 2.12e-01
HS-GAG-biosynthesis 23 1.16e-04 1.41e-03 0.47500 0.434000 1.92e-01 3.13e-04 1.12e-01
TP53-Regulates-Metabolic-Genes 85 1.59e-07 3.92e-06 0.47200 -0.335000 -3.33e-01 9.34e-08 1.13e-07
Keratan-sulfate-biosynthesis 22 1.62e-02 7.16e-02 0.47100 0.349000 3.15e-01 4.55e-03 1.05e-02
Inflammasomes 18 3.15e-02 1.18e-01 0.47000 0.306000 3.57e-01 2.47e-02 8.75e-03
Signaling-by-Retinoic-Acid 32 1.88e-03 1.35e-02 0.47000 -0.300000 -3.62e-01 3.36e-03 3.98e-04
AKT-phosphorylates-targets-in-the-nucleus 10 1.58e-01 3.48e-01 0.46900 -0.320000 -3.44e-01 7.99e-02 5.99e-02
EPHB-mediated-forward-signaling 32 2.71e-03 1.77e-02 0.46900 0.346000 3.16e-01 7.13e-04 1.97e-03
Synthesis-of-PA 27 8.76e-03 4.70e-02 0.46000 -0.331000 -3.19e-01 2.91e-03 4.10e-03
Fatty-acid-metabolism 131 2.54e-11 1.16e-09 0.46000 -0.294000 -3.53e-01 6.46e-09 2.95e-12
Glycogen-metabolism 25 1.24e-02 5.97e-02 0.45900 -0.333000 -3.16e-01 3.93e-03 6.21e-03
Voltage-gated-Potassium-channels 22 1.44e-02 6.58e-02 0.45900 -0.359000 -2.87e-01 3.61e-03 2.00e-02
EPHA-mediated-growth-cone-collapse 14 1.40e-02 6.47e-02 0.45900 0.213000 4.06e-01 1.67e-01 8.54e-03
Nucleobase-biosynthesis 13 1.07e-01 2.68e-01 0.44800 -0.336000 -2.97e-01 3.58e-02 6.41e-02
p75NTR-signals-via-NF-kB 16 6.76e-02 2.02e-01 0.44200 0.290000 3.33e-01 4.43e-02 2.10e-02
RHO-GTPases-Activate-ROCKs 18 1.49e-02 6.71e-02 0.43800 0.228000 3.74e-01 9.39e-02 6.03e-03
NCAM1-interactions 30 8.78e-03 4.70e-02 0.43700 0.308000 3.10e-01 3.50e-03 3.34e-03
Receptor-type-tyrosine-protein-phosphatases 15 5.56e-02 1.81e-01 0.43600 0.354000 2.54e-01 1.76e-02 8.89e-02
Intraflagellar-transport 36 1.85e-03 1.33e-02 0.43500 0.342000 2.69e-01 3.92e-04 5.28e-03
Signaling-by-PDGF 48 6.72e-04 5.77e-03 0.42600 0.313000 2.89e-01 1.75e-04 5.29e-04
Integrin-signaling 26 1.29e-02 6.17e-02 0.42500 0.334000 2.62e-01 3.20e-03 2.06e-02
ATF6-(ATF6-alpha)-activates-chaperone-genes 10 1.74e-01 3.69e-01 0.42300 -0.339000 -2.53e-01 6.31e-02 1.66e-01
Pyrimidine-salvage 10 4.71e-02 1.59e-01 0.42300 0.174000 3.85e-01 3.42e-01 3.50e-02
Amine-ligand-binding-receptors 12 5.12e-02 1.70e-01 0.41800 -0.368000 -1.97e-01 2.72e-02 2.37e-01
JNK-(c-Jun-kinases)-phosphorylation-and--activation-mediated-by-activated-human-TAK1 17 8.52e-02 2.34e-01 0.41800 -0.300000 -2.91e-01 3.21e-02 3.81e-02
O-linked-glycosylation 74 6.33e-07 1.45e-05 0.41200 0.346000 2.24e-01 2.66e-07 8.88e-04
Purine-ribonucleoside-monophosphate-biosynthesis 10 1.30e-01 3.13e-01 0.41100 -0.350000 -2.16e-01 5.52e-02 2.38e-01
O-linked-glycosylation-of-mucins 32 1.25e-05 2.29e-04 0.41100 0.386000 1.41e-01 1.55e-04 1.69e-01
Vitamin-B5-(pantothenate)-metabolism 15 1.27e-01 3.08e-01 0.40800 -0.288000 -2.88e-01 5.34e-02 5.33e-02
Sema4D-in-semaphorin-signaling 23 2.28e-02 9.29e-02 0.40700 0.240000 3.28e-01 4.64e-02 6.42e-03
TP53-Regulates-Transcription-of-Genes-Involved-in-G1-Cell-Cycle-Arrest 13 1.46e-01 3.33e-01 0.40600 0.314000 2.56e-01 4.96e-02 1.10e-01
Josephin-domain-DUBs 10 2.22e-01 4.21e-01 0.40500 -0.317000 -2.53e-01 8.27e-02 1.66e-01
FOXO-mediated-transcription-of-cell-death-genes 14 2.48e-02 9.96e-02 0.40500 -0.366000 -1.75e-01 1.79e-02 2.57e-01
Elevation-of-cytosolic-Ca2+-levels 11 7.10e-02 2.07e-01 0.40500 0.187000 3.59e-01 2.84e-01 3.92e-02
FCGR-activation 11 2.24e-01 4.21e-01 0.40300 0.273000 2.96e-01 1.16e-01 8.93e-02
mTOR-signalling 37 4.57e-03 2.78e-02 0.40300 -0.254000 -3.12e-01 7.41e-03 1.03e-03
PI-3K-cascade:FGFR3 12 1.72e-01 3.66e-01 0.40200 -0.253000 -3.13e-01 1.29e-01 6.06e-02
Cell-extracellular-matrix-interactions 16 3.67e-02 1.34e-01 0.40200 0.203000 3.47e-01 1.60e-01 1.64e-02
cGMP-effects 12 9.11e-02 2.41e-01 0.40000 0.205000 3.43e-01 2.19e-01 3.96e-02
Processing-of-Intronless-Pre-mRNAs 18 9.33e-02 2.44e-01 0.39900 -0.286000 -2.77e-01 3.54e-02 4.19e-02
Caspase-activation-via-extrinsic-apoptotic-signalling-pathway 22 4.06e-02 1.46e-01 0.39700 0.312000 2.46e-01 1.14e-02 4.57e-02
Gap-junction-trafficking 13 1.78e-01 3.72e-01 0.39600 0.294000 2.64e-01 6.62e-02 9.90e-02
Presynaptic-depolarization-and-calcium-channel-opening 10 2.06e-03 1.45e-02 0.39600 0.022500 3.95e-01 9.02e-01 3.06e-02
DARPP-32-events 22 7.90e-03 4.31e-02 0.39500 -0.187000 -3.48e-01 1.29e-01 4.75e-03
Termination-of-O-glycan-biosynthesis 10 1.12e-03 8.70e-03 0.39100 0.391000 -5.26e-03 3.24e-02 9.77e-01
Regulation-of-Apoptosis 49 1.45e-05 2.61e-04 0.39000 -0.347000 -1.77e-01 2.60e-05 3.17e-02
Signal-transduction-by-L1 21 1.19e-02 5.83e-02 0.38800 0.341000 1.85e-01 6.77e-03 1.42e-01
Diseases-associated-with-the-TLR-signaling-cascade 22 6.01e-02 1.87e-01 0.38800 0.259000 2.89e-01 3.53e-02 1.90e-02
Diseases-of-Immune-System 22 6.01e-02 1.87e-01 0.38800 0.259000 2.89e-01 3.53e-02 1.90e-02
Post-chaperonin-tubulin-folding-pathway 18 1.05e-01 2.65e-01 0.38500 0.259000 2.85e-01 5.69e-02 3.62e-02
Diseases-associated-with-O-glycosylation-of-proteins 46 3.63e-03 2.28e-02 0.38400 0.276000 2.68e-01 1.23e-03 1.70e-03
Synthesis-of-PE 11 1.74e-01 3.69e-01 0.38400 -0.318000 -2.16e-01 6.81e-02 2.16e-01
NF-kB-is-activated-and-signals-survival 13 1.93e-01 3.90e-01 0.38100 0.247000 2.90e-01 1.23e-01 7.05e-02
Platelet-Aggregation-(Plug-Formation) 29 3.11e-02 1.17e-01 0.38000 0.266000 2.71e-01 1.30e-02 1.15e-02
TNFR1-induced-proapoptotic-signaling 12 2.28e-01 4.26e-01 0.38000 0.285000 2.51e-01 8.79e-02 1.32e-01
Gap-junction-trafficking-and-regulation 15 1.59e-01 3.49e-01 0.37700 0.285000 2.47e-01 5.62e-02 9.82e-02
Vif-mediated-degradation-of-APOBEC3G 48 3.71e-05 5.65e-04 0.37600 -0.335000 -1.70e-01 5.91e-05 4.14e-02
FRS-mediated-FGFR3-signaling 14 1.75e-01 3.69e-01 0.37600 -0.241000 -2.88e-01 1.18e-01 6.21e-02
p75NTR-recruits-signalling-complexes 13 2.17e-01 4.16e-01 0.37300 0.251000 2.76e-01 1.17e-01 8.46e-02
Signaling-by-high-kinase-activity-BRAF-mutants 31 2.73e-02 1.07e-01 0.37300 0.272000 2.55e-01 8.73e-03 1.40e-02
G-protein-activation 16 7.03e-02 2.06e-01 0.37000 0.316000 1.94e-01 2.89e-02 1.80e-01
Biosynthesis-of-DHA-derived-SPMs 11 2.81e-01 4.86e-01 0.36900 -0.247000 -2.74e-01 1.57e-01 1.15e-01
RORA-activates-gene-expression 18 1.96e-02 8.24e-02 0.36600 -0.157000 -3.31e-01 2.50e-01 1.50e-02
PI-3K-cascade:FGFR4 12 1.46e-01 3.34e-01 0.36600 -0.192000 -3.11e-01 2.49e-01 6.22e-02
SHC1-events-in-EGFR-signaling 12 1.77e-01 3.72e-01 0.36500 0.303000 2.05e-01 6.96e-02 2.20e-01
MicroRNA-(miRNA)-biogenesis 23 6.45e-02 1.95e-01 0.36500 -0.282000 -2.32e-01 1.92e-02 5.44e-02
Synthesis-of-bile-acids-and-bile-salts-via-7alpha-hydroxycholesterol 12 2.08e-01 4.08e-01 0.36500 -0.216000 -2.93e-01 1.94e-01 7.86e-02
Role-of-LAT2/NTAL/LAB-on-calcium-mobilization 14 1.70e-01 3.63e-01 0.36400 0.221000 2.90e-01 1.53e-01 6.05e-02
RUNX2-regulates-bone-development 27 4.40e-02 1.53e-01 0.36300 0.277000 2.34e-01 1.26e-02 3.51e-02
Interferon-alpha/beta-signaling 40 1.39e-08 4.33e-07 0.36300 0.047900 3.60e-01 6.01e-01 8.18e-05
Activation-of-RAC1 12 1.16e-01 2.87e-01 0.36300 0.317000 1.76e-01 5.70e-02 2.92e-01
COPI-dependent-Golgi-to-ER-retrograde-traffic 74 1.18e-06 2.61e-05 0.36200 0.319000 1.71e-01 2.15e-06 1.09e-02
Regulation-of-FOXO-transcriptional-activity-by-acetylation 10 3.26e-01 5.28e-01 0.35900 -0.234000 -2.73e-01 2.00e-01 1.36e-01
Glycerophospholipid-biosynthesis 102 1.98e-05 3.42e-04 0.35900 -0.253000 -2.55e-01 1.02e-05 8.93e-06
alpha-linolenic-(omega3)-and-linoleic-(omega6)-acid-metabolism 10 3.33e-01 5.31e-01 0.35900 -0.238000 -2.69e-01 1.93e-01 1.41e-01
alpha-linolenic-acid-(ALA)-metabolism 10 3.33e-01 5.31e-01 0.35900 -0.238000 -2.69e-01 1.93e-01 1.41e-01
Vpu-mediated-degradation-of-CD4 48 5.10e-05 7.25e-04 0.35800 -0.323000 -1.54e-01 1.09e-04 6.44e-02
N-glycan-antennae-elongation-in-the-medial/trans-Golgi 20 2.41e-04 2.49e-03 0.35500 0.351000 5.31e-02 6.62e-03 6.81e-01
Chk1/Chk2(Cds1)-mediated-inactivation-of-Cyclin-B:Cdk1-complex 12 2.76e-01 4.83e-01 0.35100 0.228000 2.67e-01 1.72e-01 1.10e-01
Regulation-of-actin-dynamics-for-phagocytic-cup-formation 59 2.59e-03 1.70e-02 0.35000 0.246000 2.49e-01 1.10e-03 9.59e-04
Nephrin-family-interactions 18 2.82e-02 1.09e-01 0.34800 0.148000 3.15e-01 2.77e-01 2.08e-02
Regulation-of-ornithine-decarboxylase-(ODC) 46 3.97e-05 5.96e-04 0.34700 -0.320000 -1.35e-01 1.73e-04 1.13e-01
Metabolism-of-amino-acids-and-derivatives 256 1.02e-11 5.03e-10 0.34700 -0.241000 -2.51e-01 3.75e-11 5.47e-12
activated-TAK1-mediates-p38-MAPK-activation 18 1.52e-01 3.39e-01 0.34600 -0.264000 -2.23e-01 5.28e-02 1.01e-01
Retrograde-neurotrophin-signalling 12 2.29e-01 4.27e-01 0.34500 0.282000 1.99e-01 9.07e-02 2.32e-01
Acyl-chain-remodelling-of-PC 18 9.31e-02 2.44e-01 0.34500 -0.288000 -1.90e-01 3.47e-02 1.63e-01
FRS-mediated-FGFR4-signaling 14 1.60e-01 3.51e-01 0.34300 -0.190000 -2.86e-01 2.19e-01 6.36e-02
Activation-of-the-AP-1-family-of-transcription-factors 10 1.35e-01 3.18e-01 0.34300 -0.142000 -3.13e-01 4.37e-01 8.70e-02
Regulation-of-activated-PAK-2p34-by-proteasome-mediated-degradation 46 6.86e-05 9.33e-04 0.34300 -0.315000 -1.37e-01 2.24e-04 1.08e-01
mRNA-decay-by-5'-to-3'-exoribonuclease 15 2.12e-01 4.12e-01 0.34100 -0.218000 -2.63e-01 1.44e-01 7.81e-02
Sema4D-induced-cell-migration-and-growth-cone-collapse 19 7.95e-02 2.26e-01 0.34000 0.183000 2.86e-01 1.67e-01 3.07e-02
MET-activates-RAP1-and-RAC1 11 8.34e-02 2.32e-01 0.34000 0.316000 1.24e-01 6.94e-02 4.76e-01
Interleukin-10-signaling 23 3.81e-02 1.39e-01 0.34000 0.291000 1.76e-01 1.59e-02 1.45e-01
Ubiquitin-Mediated-Degradation-of-Phosphorylated-Cdc25A 48 2.72e-05 4.30e-04 0.33900 -0.315000 -1.27e-01 1.64e-04 1.29e-01
p53-Independent-DNA-Damage-Response 48 2.72e-05 4.30e-04 0.33900 -0.315000 -1.27e-01 1.64e-04 1.29e-01
p53-Independent-G1/S-DNA-damage-checkpoint 48 2.72e-05 4.30e-04 0.33900 -0.315000 -1.27e-01 1.64e-04 1.29e-01
Diseases-of-glycosylation 113 1.33e-06 2.82e-05 0.33900 0.278000 1.93e-01 3.33e-07 3.94e-04
Retinoid-metabolism-and-transport 29 6.43e-02 1.95e-01 0.33800 0.239000 2.39e-01 2.60e-02 2.57e-02
Synthesis-of-glycosylphosphatidylinositol-(GPI) 17 1.99e-01 3.95e-01 0.33800 -0.245000 -2.32e-01 8.03e-02 9.74e-02
CRMPs-in-Sema3A-signaling 15 2.09e-01 4.08e-01 0.33600 0.208000 2.64e-01 1.62e-01 7.69e-02
Signaling-by-FGFR3-in-disease 16 1.44e-01 3.31e-01 0.33500 -0.189000 -2.77e-01 1.92e-01 5.47e-02
Signaling-by-FGFR3-point-mutants-in-cancer 16 1.44e-01 3.31e-01 0.33500 -0.189000 -2.77e-01 1.92e-01 5.47e-02
Apoptotic-cleavage-of-cellular-proteins 34 1.50e-02 6.72e-02 0.33500 0.279000 1.86e-01 4.86e-03 6.05e-02
RUNX2-regulates-osteoblast-differentiation 21 9.40e-02 2.45e-01 0.33500 0.271000 1.97e-01 3.14e-02 1.19e-01
Signaling-by-Activin 11 1.25e-02 6.00e-02 0.33500 0.333000 3.84e-02 5.60e-02 8.25e-01
SCF-beta-TrCP-mediated-degradation-of-Emi1 51 8.26e-05 1.06e-03 0.33500 -0.303000 -1.42e-01 1.81e-04 8.02e-02
Regulation-of-RUNX1-Expression-and-Activity 17 1.89e-01 3.87e-01 0.33400 0.216000 2.55e-01 1.23e-01 6.87e-02
ABC-family-proteins-mediated-transport 89 1.75e-05 3.10e-04 0.33400 -0.279000 -1.85e-01 5.62e-06 2.63e-03
Signaling-by-MET 60 2.20e-04 2.31e-03 0.33400 0.287000 1.70e-01 1.19e-04 2.28e-02
Degradation-of-DVL 52 2.99e-04 2.99e-03 0.33300 -0.293000 -1.58e-01 2.56e-04 4.90e-02
Glucose-metabolism 79 1.57e-04 1.78e-03 0.33300 -0.195000 -2.70e-01 2.73e-03 3.44e-05
Fcgamma-receptor-(FCGR)-dependent-phagocytosis 82 3.49e-04 3.35e-03 0.33200 0.213000 2.55e-01 8.87e-04 6.69e-05
Degradation-of-GLI1-by-the-proteasome 55 1.82e-04 1.99e-03 0.33100 -0.292000 -1.55e-01 1.78e-04 4.67e-02
Activation-of-IRF3/IRF7-mediated-by-TBK1/IKK-epsilon 15 1.78e-01 3.72e-01 0.33000 0.188000 2.72e-01 2.07e-01 6.86e-02
Acyl-chain-remodelling-of-PE 17 1.71e-01 3.66e-01 0.32800 -0.262000 -1.98e-01 6.15e-02 1.57e-01
SMAD2/SMAD3:SMAD4-heterotrimer-regulates-transcription 31 1.02e-02 5.21e-02 0.32400 0.285000 1.53e-01 6.02e-03 1.40e-01
Interleukin-15-signaling 14 1.20e-01 2.94e-01 0.32300 -0.150000 -2.86e-01 3.30e-01 6.39e-02
Oxygen-dependent-proline-hydroxylation-of-Hypoxia-inducible-Factor-Alpha 60 4.60e-04 4.17e-03 0.32300 -0.276000 -1.67e-01 2.17e-04 2.57e-02
ABC-transporter-disorders 66 7.84e-05 1.01e-03 0.32200 -0.283000 -1.55e-01 7.23e-05 2.99e-02
Activated-NTRK2-signals-through-FRS2-and-FRS3 10 1.04e-01 2.64e-01 0.32100 -0.103000 -3.04e-01 5.72e-01 9.64e-02
Defective-CFTR-causes-cystic-fibrosis 55 4.89e-04 4.38e-03 0.32000 -0.280000 -1.56e-01 3.33e-04 4.53e-02
CDT1-association-with-the-CDC6:ORC:origin-complex 55 2.89e-05 4.51e-04 0.32000 -0.296000 -1.23e-01 1.49e-04 1.16e-01
Glycosphingolipid-metabolism 34 1.75e-02 7.52e-02 0.32000 0.270000 1.71e-01 6.41e-03 8.38e-02
Energy-dependent-regulation-of-mTOR-by-LKB1-AMPK 29 5.68e-02 1.83e-01 0.31900 -0.191000 -2.56e-01 7.52e-02 1.73e-02
IRAK4-deficiency-(TLR2/4) 10 4.08e-01 5.96e-01 0.31900 0.205000 2.44e-01 2.62e-01 1.81e-01
MyD88-deficiency-(TLR2/4) 10 4.08e-01 5.96e-01 0.31900 0.205000 2.44e-01 2.62e-01 1.81e-01
Negative-regulation-of-NOTCH4-signaling 51 1.22e-04 1.47e-03 0.31800 -0.291000 -1.28e-01 3.29e-04 1.14e-01
FBXL7-down-regulates-AURKA-during-mitotic-entry-and-in-early-mitosis 51 1.71e-04 1.90e-03 0.31800 -0.289000 -1.32e-01 3.60e-04 1.04e-01
Hh-mutants-that-don't-undergo-autocatalytic-processing-are-degraded-by-ERAD 51 4.47e-04 4.11e-03 0.31700 -0.283000 -1.43e-01 4.82e-04 7.68e-02
Interconversion-of-nucleotide-di--and-triphosphates 24 1.35e-01 3.18e-01 0.31700 -0.218000 -2.29e-01 6.41e-02 5.17e-02
Activation-of-gene-expression-by-SREBF-(SREBP) 42 1.14e-02 5.66e-02 0.31600 -0.178000 -2.61e-01 4.60e-02 3.47e-03
Autodegradation-of-the-E3-ubiquitin-ligase-COP1 47 7.41e-05 9.77e-04 0.31500 -0.295000 -1.10e-01 4.69e-04 1.92e-01
Processing-of-Capped-Intronless-Pre-mRNA 26 9.33e-02 2.44e-01 0.31400 -0.194000 -2.47e-01 8.67e-02 2.95e-02
Adenylate-cyclase-inhibitory-pathway 12 3.43e-01 5.38e-01 0.31300 0.196000 2.44e-01 2.39e-01 1.43e-01
Metabolism-of-fat-soluble-vitamins 33 5.83e-02 1.84e-01 0.31200 0.240000 1.99e-01 1.72e-02 4.77e-02
EPH-Ephrin-signaling 82 2.92e-04 2.94e-03 0.31200 0.254000 1.80e-01 6.99e-05 4.81e-03
Selective-autophagy 50 1.73e-02 7.49e-02 0.31100 -0.229000 -2.11e-01 5.14e-03 9.95e-03
GRB2-events-in-EGFR-signaling 11 3.00e-01 5.09e-01 0.31100 0.261000 1.70e-01 1.35e-01 3.30e-01
Interleukin-4-and-Interleukin-13-signaling 76 5.17e-05 7.26e-04 0.31000 0.271000 1.51e-01 4.48e-05 2.30e-02
GAB1-signalosome 15 1.37e-01 3.22e-01 0.31000 0.272000 1.49e-01 6.87e-02 3.18e-01
TP53-Regulates-Transcription-of-Caspase-Activators-and-Caspases 10 3.26e-01 5.28e-01 0.30900 0.262000 1.65e-01 1.52e-01 3.66e-01
Regulation-of-TLR-by-endogenous-ligand 12 6.30e-02 1.94e-01 0.30900 0.088600 2.96e-01 5.95e-01 7.61e-02
AUF1-(hnRNP-D0)-binds-and-destabilizes-mRNA 50 9.96e-05 1.22e-03 0.30800 -0.286000 -1.13e-01 4.63e-04 1.68e-01
Deadenylation-of-mRNA 20 1.64e-01 3.56e-01 0.30700 -0.186000 -2.45e-01 1.50e-01 5.82e-02
Resolution-of-D-loop-Structures-through-Holliday-Junction-Intermediates 30 5.58e-02 1.81e-01 0.30500 0.176000 2.50e-01 9.54e-02 1.80e-02
RHO-GTPases-activate-CIT 18 1.39e-01 3.26e-01 0.30500 0.162000 2.58e-01 2.34e-01 5.78e-02
DNA-strand-elongation 31 8.91e-03 4.73e-02 0.30500 0.130000 2.76e-01 2.12e-01 7.85e-03
Resolution-of-D-Loop-Structures 31 6.30e-02 1.94e-01 0.30500 0.184000 2.43e-01 7.70e-02 1.92e-02
Metabolism-of-Angiotensinogen-to-Angiotensins 11 3.70e-01 5.64e-01 0.30500 0.244000 1.82e-01 1.61e-01 2.96e-01
Amino-acid-transport-across-the-plasma-membrane 21 1.96e-01 3.93e-01 0.30500 0.223000 2.08e-01 7.74e-02 9.95e-02
Chemokine-receptors-bind-chemokines 20 2.50e-03 1.65e-02 0.30300 0.299000 4.74e-02 2.05e-02 7.14e-01
Resolution-of-D-loop-Structures-through-Synthesis-Dependent-Strand-Annealing-(SDSA) 25 6.78e-02 2.02e-01 0.30300 0.161000 2.56e-01 1.64e-01 2.67e-02
Golgi-to-ER-retrograde-transport 105 1.65e-06 3.35e-05 0.30200 0.266000 1.44e-01 2.62e-06 1.07e-02
Loss-of-function-of-MECP2-in-Rett-syndrome 12 7.47e-02 2.16e-01 0.30100 -0.088300 -2.88e-01 5.96e-01 8.39e-02
Pervasive-developmental-disorders 12 7.47e-02 2.16e-01 0.30100 -0.088300 -2.88e-01 5.96e-01 8.39e-02
GLI3-is-processed-to-GLI3R-by-the-proteasome 55 9.59e-04 7.81e-03 0.30000 -0.264000 -1.43e-01 7.06e-04 6.74e-02
Metabolism 1613 5.51e-49 1.76e-46 0.30000 -0.200000 -2.24e-01 1.76e-39 2.43e-49
MAP2K-and-MAPK-activation 35 7.62e-02 2.19e-01 0.29800 0.212000 2.10e-01 3.02e-02 3.16e-02
HSF1-activation 23 5.89e-02 1.85e-01 0.29600 -0.261000 -1.41e-01 3.05e-02 2.42e-01
Response-to-elevated-platelet-cytosolic-Ca2+ 113 1.45e-04 1.69e-03 0.29600 0.229000 1.88e-01 2.63e-05 5.63e-04
Formation-of-Incision-Complex-in-GG-NER 43 6.52e-03 3.71e-02 0.29600 -0.145000 -2.58e-01 9.92e-02 3.44e-03
RHO-GTPases-Activate-WASPs-and-WAVEs 36 6.99e-02 2.05e-01 0.29600 0.219000 1.99e-01 2.29e-02 3.90e-02
Degradation-of-GLI2-by-the-proteasome 55 1.02e-03 8.12e-03 0.29600 -0.261000 -1.39e-01 8.06e-04 7.55e-02
Platelet-degranulation 108 9.24e-05 1.17e-03 0.29600 0.238000 1.75e-01 1.91e-05 1.69e-03
Methylation 12 4.12e-01 5.98e-01 0.29600 -0.219000 -1.98e-01 1.88e-01 2.35e-01
Semaphorin-interactions 61 1.09e-02 5.51e-02 0.29600 0.197000 2.20e-01 7.77e-03 2.94e-03
Downstream-signaling-of-activated-FGFR3 19 1.41e-01 3.28e-01 0.29500 -0.156000 -2.50e-01 2.39e-01 5.93e-02
tRNA-processing 116 2.53e-04 2.59e-03 0.29500 -0.208000 -2.08e-01 1.08e-04 1.08e-04
mRNA-Capping 29 1.24e-01 3.00e-01 0.29400 -0.214000 -2.02e-01 4.64e-02 5.97e-02
Role-of-phospholipids-in-phagocytosis 24 1.61e-01 3.52e-01 0.29400 0.189000 2.25e-01 1.09e-01 5.63e-02
mRNA-3'-end-processing 54 2.11e-02 8.77e-02 0.29400 -0.212000 -2.03e-01 6.95e-03 1.01e-02
RHO-GTPases-activate-PAKs 20 8.52e-02 2.34e-01 0.29300 0.137000 2.59e-01 2.88e-01 4.52e-02
Hh-mutants-abrogate-ligand-secretion 53 3.99e-04 3.74e-03 0.29200 -0.267000 -1.19e-01 7.77e-04 1.34e-01
Signaling-by-Leptin 10 2.32e-01 4.31e-01 0.29200 -0.120000 -2.66e-01 5.11e-01 1.45e-01
Stabilization-of-p53 51 7.50e-05 9.79e-04 0.29100 -0.276000 -9.40e-02 6.62e-04 2.46e-01
Cellular-response-to-hypoxia 68 8.97e-04 7.40e-03 0.29000 -0.248000 -1.50e-01 4.10e-04 3.31e-02
Formation-of-apoptosome 10 4.97e-01 6.64e-01 0.28900 -0.199000 -2.11e-01 2.77e-01 2.49e-01
Regulation-of-the-apoptosome-activity 10 4.97e-01 6.64e-01 0.28900 -0.199000 -2.11e-01 2.77e-01 2.49e-01
Potassium-Channels 56 2.20e-03 1.51e-02 0.28900 -0.251000 -1.44e-01 1.17e-03 6.24e-02
Signaling-by-FGFR2-IIIa-TM 19 2.48e-01 4.46e-01 0.28900 -0.221000 -1.87e-01 9.55e-02 1.59e-01
Cross-presentation-of-soluble-exogenous-antigens-(endosomes) 44 5.19e-04 4.61e-03 0.28900 -0.271000 -1.00e-01 1.86e-03 2.50e-01
TRAF3-dependent-IRF-activation-pathway 12 1.23e-02 5.94e-02 0.28800 -0.002980 2.88e-01 9.86e-01 8.43e-02
Ubiquitin-dependent-degradation-of-Cyclin-D 48 1.72e-04 1.90e-03 0.28800 -0.272000 -9.36e-02 1.11e-03 2.62e-01
Signaling-by-FGFR4-in-disease 10 1.72e-01 3.66e-01 0.28800 -0.096200 -2.71e-01 5.98e-01 1.38e-01
EGFR-downregulation 27 1.21e-01 2.96e-01 0.28700 0.228000 1.75e-01 4.05e-02 1.16e-01
Zinc-transporters 12 2.63e-01 4.65e-01 0.28600 0.250000 1.39e-01 1.34e-01 4.05e-01
Signaling-by-NODAL 11 6.48e-02 1.95e-01 0.28600 -0.054200 -2.81e-01 7.56e-01 1.07e-01
PPARA-activates-gene-expression 109 1.93e-04 2.08e-03 0.28600 -0.172000 -2.28e-01 1.94e-03 3.85e-05
mRNA-Splicing---Minor-Pathway 51 1.65e-02 7.25e-02 0.28600 -0.230000 -1.69e-01 4.47e-03 3.65e-02
Regulation-of-glycolysis-by-fructose-2,6-bisphosphate-metabolism 10 2.21e-01 4.21e-01 0.28500 -0.110000 -2.64e-01 5.48e-01 1.49e-01
Synaptic-adhesion-like-molecules 15 1.73e-03 1.27e-02 0.28500 0.283000 -3.47e-02 5.76e-02 8.16e-01
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE 27 1.55e-01 3.45e-01 0.28500 -0.213000 -1.90e-01 5.60e-02 8.76e-02
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE-during-HIV-infection 27 1.55e-01 3.45e-01 0.28500 -0.213000 -1.90e-01 5.60e-02 8.76e-02
RIP-mediated-NFkB-activation-via-ZBP1 17 3.13e-01 5.18e-01 0.28500 0.210000 1.93e-01 1.34e-01 1.69e-01
Regulation-of-PTEN-stability-and-activity 65 3.58e-04 3.39e-03 0.28300 -0.253000 -1.27e-01 4.21e-04 7.71e-02
Glycogen-storage-diseases 13 3.33e-01 5.31e-01 0.28300 -0.233000 -1.61e-01 1.46e-01 3.16e-01
SEMA3A-Plexin-repulsion-signaling-by-inhibiting-Integrin-adhesion 14 3.83e-01 5.74e-01 0.28300 0.187000 2.12e-01 2.26e-01 1.69e-01
ADP-signalling-through-P2Y-purinoceptor-12 15 1.40e-01 3.27e-01 0.28200 0.256000 1.20e-01 8.66e-02 4.22e-01
Regulation-of-lipid-metabolism-by-PPARalpha 111 1.88e-04 2.04e-03 0.28200 -0.168000 -2.26e-01 2.28e-03 3.88e-05
STING-mediated-induction-of-host-immune-responses 14 2.96e-02 1.13e-01 0.28200 0.047900 2.77e-01 7.56e-01 7.23e-02
NIK-->noncanonical-NF-kB-signaling 55 5.97e-04 5.19e-03 0.28000 -0.256000 -1.15e-01 1.03e-03 1.41e-01
Biosynthesis-of-specialized-proresolving-mediators-(SPMs) 13 3.74e-01 5.67e-01 0.28000 -0.169000 -2.24e-01 2.91e-01 1.63e-01
Prostacyclin-signalling-through-prostacyclin-receptor 13 1.66e-01 3.60e-01 0.27900 0.256000 1.12e-01 1.10e-01 4.85e-01
Transcriptional-activity-of-SMAD2/SMAD3:SMAD4-heterotrimer 43 1.40e-03 1.06e-02 0.27900 0.260000 1.02e-01 3.18e-03 2.50e-01
Nucleotide-like-(purinergic)-receptors 12 3.12e-01 5.18e-01 0.27900 -0.239000 -1.43e-01 1.51e-01 3.91e-01
RHO-GTPases-activate-KTN1 10 3.52e-01 5.46e-01 0.27800 0.243000 1.35e-01 1.84e-01 4.59e-01
mRNA-Splicing---Major-Pathway 172 1.87e-05 3.27e-04 0.27700 -0.191000 -2.01e-01 1.53e-05 5.88e-06
Insulin-processing 21 2.55e-01 4.56e-01 0.27700 0.184000 2.06e-01 1.44e-01 1.02e-01
Degradation-of-AXIN 51 2.92e-04 2.94e-03 0.27600 -0.259000 -9.33e-02 1.36e-03 2.49e-01
Downstream-signaling-of-activated-FGFR4 19 9.61e-02 2.48e-01 0.27500 -0.118000 -2.49e-01 3.74e-01 6.05e-02
SUMOylation-of-intracellular-receptors 27 8.86e-02 2.38e-01 0.27400 -0.144000 -2.33e-01 1.94e-01 3.62e-02
ABC-transporters-in-lipid-homeostasis 14 4.07e-01 5.94e-01 0.27400 -0.181000 -2.06e-01 2.41e-01 1.83e-01
BMAL1:CLOCK,NPAS2-activates-circadian-gene-expression 25 2.45e-02 9.87e-02 0.27300 -0.097700 -2.55e-01 3.98e-01 2.75e-02
TGF-beta-receptor-signaling-in-EMT-(epithelial-to-mesenchymal-transition) 15 1.67e-01 3.60e-01 0.27200 0.246000 1.17e-01 9.96e-02 4.31e-01
Senescence-Associated-Secretory-Phenotype-(SASP) 45 5.00e-03 3.03e-02 0.27200 0.245000 1.18e-01 4.48e-03 1.71e-01
Synthesis-of-PIPs-at-the-plasma-membrane 51 3.76e-03 2.34e-02 0.27200 0.242000 1.24e-01 2.84e-03 1.25e-01
Interleukin-37-signaling 18 3.33e-01 5.31e-01 0.27200 0.190000 1.94e-01 1.62e-01 1.55e-01
CREB1-phosphorylation-through-the-activation-of-Adenylate-Cyclase 10 2.40e-01 4.38e-01 0.27200 -0.100000 -2.52e-01 5.84e-01 1.67e-01
Phosphorylation-of-the-APC/C 18 6.87e-02 2.04e-01 0.27100 0.254000 9.61e-02 6.22e-02 4.80e-01
RNA-Polymerase-II-Transcription-Termination 62 2.21e-02 9.10e-02 0.27100 -0.183000 -2.00e-01 1.26e-02 6.62e-03
NCAM-signaling-for-neurite-out-growth 50 4.15e-02 1.48e-01 0.26900 0.174000 2.06e-01 3.39e-02 1.18e-02
Common-Pathway-of-Fibrin-Clot-Formation 10 2.26e-01 4.23e-01 0.26900 0.093400 2.52e-01 6.09e-01 1.67e-01
IRF3-mediated-induction-of-type-I-IFN 11 1.78e-01 3.72e-01 0.26900 0.088100 2.54e-01 6.13e-01 1.45e-01
mRNA-Splicing 180 2.48e-05 4.17e-04 0.26800 -0.190000 -1.89e-01 1.16e-05 1.20e-05
Condensation-of-Prometaphase-Chromosomes 11 4.96e-01 6.64e-01 0.26800 0.172000 2.06e-01 3.24e-01 2.37e-01
PIWI-interacting-RNA-(piRNA)-biogenesis 16 8.26e-02 2.31e-01 0.26800 -0.253000 -8.77e-02 7.96e-02 5.44e-01
GPVI-mediated-activation-cascade 29 1.45e-01 3.32e-01 0.26800 0.211000 1.65e-01 4.96e-02 1.24e-01
G-beta:gamma-signalling-through-CDC42 14 1.55e-01 3.44e-01 0.26800 0.247000 1.02e-01 1.09e-01 5.08e-01
FGFR2-mutant-receptor-activation 24 2.08e-01 4.08e-01 0.26700 -0.209000 -1.66e-01 7.66e-02 1.59e-01
ZBP1(DAI)-mediated-induction-of-type-I-IFNs 20 2.81e-01 4.86e-01 0.26700 0.206000 1.70e-01 1.11e-01 1.89e-01
HIV-Transcription-Initiation 45 5.87e-02 1.84e-01 0.26700 -0.170000 -2.05e-01 4.84e-02 1.73e-02
RNA-Polymerase-II-HIV-Promoter-Escape 45 5.87e-02 1.84e-01 0.26700 -0.170000 -2.05e-01 4.84e-02 1.73e-02
RNA-Polymerase-II-Promoter-Escape 45 5.87e-02 1.84e-01 0.26700 -0.170000 -2.05e-01 4.84e-02 1.73e-02
RNA-Polymerase-II-Transcription-Initiation 45 5.87e-02 1.84e-01 0.26700 -0.170000 -2.05e-01 4.84e-02 1.73e-02
RNA-Polymerase-II-Transcription-Initiation-And-Promoter-Clearance 45 5.87e-02 1.84e-01 0.26700 -0.170000 -2.05e-01 4.84e-02 1.73e-02
RNA-Polymerase-II-Transcription-Pre-Initiation-And-Promoter-Opening 45 5.87e-02 1.84e-01 0.26700 -0.170000 -2.05e-01 4.84e-02 1.73e-02
Deposition-of-new-CENPA-containing-nucleosomes-at-the-centromere 19 2.36e-01 4.35e-01 0.26600 0.220000 1.49e-01 9.73e-02 2.61e-01
Nucleosome-assembly 19 2.36e-01 4.35e-01 0.26600 0.220000 1.49e-01 9.73e-02 2.61e-01
Response-of-EIF2AK1-(HRI)-to-heme-deficiency 15 3.55e-01 5.49e-01 0.26500 0.157000 2.13e-01 2.91e-01 1.53e-01
Signaling-by-FGFR2-in-disease 34 1.33e-01 3.16e-01 0.26400 -0.176000 -1.97e-01 7.60e-02 4.67e-02
Recycling-pathway-of-L1 25 4.37e-02 1.52e-01 0.26400 0.242000 1.04e-01 3.60e-02 3.70e-01
Mismatch-repair-(MMR)-directed-by-MSH2:MSH3-(MutSbeta) 11 2.98e-01 5.06e-01 0.26300 -0.237000 -1.15e-01 1.74e-01 5.10e-01
Glycogen-synthesis 14 4.06e-01 5.94e-01 0.26100 -0.207000 -1.59e-01 1.80e-01 3.02e-01
Dectin-1-mediated-noncanonical-NF-kB-signaling 56 1.08e-03 8.56e-03 0.26100 -0.240000 -1.03e-01 1.94e-03 1.84e-01
Synthesis-of-IP2,-IP,-and-Ins-in-the-cytosol 13 3.09e-01 5.14e-01 0.26100 0.227000 1.28e-01 1.57e-01 4.23e-01
HSF1-dependent-transactivation 30 1.43e-01 3.30e-01 0.25900 -0.207000 -1.55e-01 4.96e-02 1.41e-01
Leading-Strand-Synthesis 13 3.20e-01 5.22e-01 0.25900 0.129000 2.24e-01 4.21e-01 1.61e-01
Polymerase-switching 13 3.20e-01 5.22e-01 0.25900 0.129000 2.24e-01 4.21e-01 1.61e-01
Polymerase-switching-on-the-C-strand-of-the-telomere 13 3.20e-01 5.22e-01 0.25900 0.129000 2.24e-01 4.21e-01 1.61e-01
Synthesis-of-PIPs-at-the-late-endosome-membrane 11 1.44e-01 3.31e-01 0.25800 -0.064800 -2.50e-01 7.10e-01 1.51e-01
PTK6-Regulates-RHO-GTPases,-RAS-GTPase-and-MAP-kinases 14 4.21e-01 6.06e-01 0.25800 0.203000 1.59e-01 1.89e-01 3.04e-01
FCERI-mediated-NF-kB-activation 73 1.92e-03 1.38e-02 0.25700 -0.223000 -1.29e-01 1.01e-03 5.75e-02
Nuclear-Receptor-transcription-pathway 43 8.62e-02 2.35e-01 0.25700 -0.167000 -1.94e-01 5.76e-02 2.74e-02
Negative-regulation-of-NMDA-receptor-mediated-neuronal-transmission 14 1.30e-01 3.13e-01 0.25600 0.243000 8.14e-02 1.16e-01 5.98e-01
Transport-of-Mature-mRNA-Derived-from-an-Intronless-Transcript 40 9.46e-02 2.46e-01 0.25500 -0.160000 -1.98e-01 8.10e-02 2.99e-02
Sphingolipid-metabolism 67 6.93e-03 3.89e-02 0.25400 0.214000 1.37e-01 2.45e-03 5.24e-02
Antimicrobial-peptides 13 3.99e-02 1.44e-01 0.25400 0.254000 1.88e-02 1.14e-01 9.07e-01
Attenuation-phase 21 1.48e-01 3.35e-01 0.25400 -0.224000 -1.20e-01 7.62e-02 3.41e-01
Amino-acids-regulate-mTORC1 48 6.92e-02 2.04e-01 0.25300 -0.165000 -1.92e-01 4.87e-02 2.12e-02
WNT-ligand-biogenesis-and-trafficking 16 3.95e-01 5.86e-01 0.25200 0.157000 1.97e-01 2.77e-01 1.73e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-Cytochrome-C-Release 16 4.02e-01 5.93e-01 0.25200 0.195000 1.59e-01 1.77e-01 2.71e-01
Interferon-gamma-signaling 58 7.00e-03 3.91e-02 0.25000 0.121000 2.19e-01 1.12e-01 3.95e-03
Metabolism-of-water-soluble-vitamins-and-cofactors 103 3.97e-03 2.46e-02 0.25000 -0.163000 -1.89e-01 4.25e-03 9.27e-04
Downregulation-of-SMAD2/3:SMAD4-transcriptional-activity 23 6.01e-03 3.47e-02 0.25000 0.248000 2.80e-02 3.95e-02 8.17e-01
Transport-of-Mature-mRNAs-Derived-from-Intronless-Transcripts 41 1.00e-01 2.56e-01 0.25000 -0.157000 -1.94e-01 8.14e-02 3.19e-02
Negative-regulation-of-MET-activity 19 3.27e-01 5.28e-01 0.24800 0.198000 1.50e-01 1.36e-01 2.59e-01
Cilium-Assembly 176 4.78e-05 6.95e-04 0.24700 0.195000 1.52e-01 8.38e-06 5.08e-04
Glutathione-conjugation 25 2.24e-01 4.21e-01 0.24700 -0.199000 -1.47e-01 8.57e-02 2.04e-01
Activation-of-the-pre-replicative-complex 32 5.28e-03 3.18e-02 0.24700 0.059900 2.39e-01 5.58e-01 1.91e-02
Keratinization 22 8.05e-02 2.28e-01 0.24600 0.228000 9.30e-02 6.40e-02 4.50e-01
Processing-of-Capped-Intron-Containing-Pre-mRNA 230 1.11e-05 2.06e-04 0.24600 -0.172000 -1.77e-01 7.62e-06 4.18e-06
Regulation-of-RUNX2-expression-and-activity 66 1.43e-04 1.68e-03 0.24600 -0.233000 -7.79e-02 1.08e-03 2.74e-01
Glucagon-type-ligand-receptors 15 8.96e-02 2.39e-01 0.24500 0.238000 6.05e-02 1.11e-01 6.85e-01
Intra-Golgi-and-retrograde-Golgi-to-ER-traffic 168 7.64e-10 2.71e-08 0.24500 0.230000 8.31e-02 2.68e-07 6.36e-02
Constitutive-Signaling-by-Overexpressed-ERBB2 10 6.07e-01 7.36e-01 0.24400 0.178000 1.67e-01 3.29e-01 3.61e-01
Caspase-activation-via-Death-Receptors-in-the-presence-of-ligand 13 5.23e-01 6.86e-01 0.24400 0.179000 1.66e-01 2.64e-01 3.01e-01
Deadenylation-dependent-mRNA-decay 50 8.39e-02 2.32e-01 0.24400 -0.166000 -1.78e-01 4.23e-02 2.93e-02
Regulation-of-FZD-by-ubiquitination 15 1.87e-01 3.83e-01 0.24200 -0.090100 -2.24e-01 5.46e-01 1.33e-01
PI-3K-cascade:FGFR2 14 2.23e-01 4.21e-01 0.24100 -0.093400 -2.23e-01 5.45e-01 1.49e-01
RHO-GTPase-Effectors 220 2.69e-05 4.30e-04 0.24100 0.165000 1.75e-01 2.50e-05 7.61e-06
Ion-homeostasis 39 8.51e-02 2.34e-01 0.24100 -0.200000 -1.34e-01 3.07e-02 1.47e-01
Sema3A-PAK-dependent-Axon-repulsion 15 4.81e-01 6.55e-01 0.24100 0.163000 1.77e-01 2.74e-01 2.35e-01
VEGFR2-mediated-vascular-permeability 25 2.79e-01 4.84e-01 0.24000 -0.185000 -1.54e-01 1.10e-01 1.83e-01
Transport-of-Mature-Transcript-to-Cytoplasm 78 2.42e-02 9.79e-02 0.24000 -0.164000 -1.75e-01 1.23e-02 7.74e-03
Interleukin-receptor-SHC-signaling 21 3.38e-01 5.36e-01 0.23900 0.186000 1.51e-01 1.41e-01 2.30e-01
Synthesis-of-PC 24 3.13e-01 5.18e-01 0.23900 -0.178000 -1.60e-01 1.32e-01 1.75e-01
Acyl-chain-remodelling-of-PG 10 4.21e-01 6.06e-01 0.23900 -0.213000 -1.08e-01 2.43e-01 5.55e-01
Sialic-acid-metabolism 26 3.27e-03 2.07e-02 0.23900 0.238000 1.68e-02 3.55e-02 8.82e-01
Carboxyterminal-post-translational-modifications-of-tubulin 26 1.02e-01 2.59e-01 0.23900 0.106000 2.14e-01 3.49e-01 5.93e-02
MET-receptor-recycling 10 5.78e-01 7.22e-01 0.23700 0.190000 1.42e-01 2.98e-01 4.36e-01
Regulation-of-signaling-by-CBL 18 3.42e-01 5.38e-01 0.23700 0.134000 1.95e-01 3.23e-01 1.51e-01
Hedgehog-ligand-biogenesis 56 2.45e-03 1.64e-02 0.23700 -0.220000 -8.77e-02 4.49e-03 2.56e-01
IL-6-type-cytokine-receptor-ligand-interactions 12 4.41e-01 6.26e-01 0.23600 0.123000 2.02e-01 4.60e-01 2.26e-01
Glycolysis 63 1.43e-02 6.57e-02 0.23600 -0.124000 -2.01e-01 8.98e-02 5.71e-03
FRS-mediated-FGFR2-signaling 16 2.45e-01 4.43e-01 0.23600 -0.103000 -2.12e-01 4.74e-01 1.42e-01
Pre-NOTCH-Transcription-and-Translation 32 2.10e-01 4.11e-01 0.23600 0.180000 1.52e-01 7.80e-02 1.37e-01
APC/C:Cdc20-mediated-degradation-of-Securin 62 6.76e-03 3.83e-02 0.23600 -0.209000 -1.09e-01 4.50e-03 1.37e-01
Unblocking-of-NMDA-receptors,-glutamate-binding-and-activation 13 1.68e-01 3.62e-01 0.23500 0.226000 6.51e-02 1.58e-01 6.84e-01
SUMOylation-of-DNA-methylation-proteins 16 1.68e-01 3.62e-01 0.23500 0.220000 8.30e-02 1.28e-01 5.66e-01
DAP12-signaling 23 3.42e-01 5.38e-01 0.23400 0.175000 1.56e-01 1.47e-01 1.94e-01
FGFR2-alternative-splicing 24 3.02e-01 5.10e-01 0.23400 -0.182000 -1.46e-01 1.22e-01 2.15e-01
WNT5A-dependent-internalization-of-FZD4 15 1.48e-01 3.35e-01 0.23200 0.222000 6.89e-02 1.37e-01 6.44e-01
SUMOylation-of-immune-response-proteins 11 6.12e-01 7.38e-01 0.23200 0.165000 1.63e-01 3.43e-01 3.49e-01
SHC-mediated-cascade:FGFR3 12 5.79e-01 7.22e-01 0.23200 -0.155000 -1.72e-01 3.51e-01 3.01e-01
Macroautophagy 99 4.33e-03 2.67e-02 0.23200 -0.134000 -1.89e-01 2.17e-02 1.16e-03
ATF6-(ATF6-alpha)-activates-chaperones 12 5.41e-01 6.94e-01 0.23100 -0.184000 -1.40e-01 2.69e-01 4.02e-01
Trafficking-and-processing-of-endosomal-TLR 11 3.36e-01 5.35e-01 0.23000 0.213000 8.73e-02 2.22e-01 6.16e-01
Neurotransmitter-release-cycle 33 5.07e-02 1.69e-01 0.23000 0.094400 2.10e-01 3.48e-01 3.73e-02
RUNX1-regulates-transcription-of-genes-involved-in-differentiation-of-HSCs 64 3.53e-04 3.37e-03 0.23000 -0.219000 -6.80e-02 2.40e-03 3.47e-01
Polo-like-kinase-mediated-events 14 5.44e-01 6.96e-01 0.22900 0.162000 1.63e-01 2.95e-01 2.92e-01
YAP1--and-WWTR1-(TAZ)-stimulated-gene-expression 14 5.03e-01 6.69e-01 0.22900 0.181000 1.41e-01 2.42e-01 3.62e-01
Endosomal-Sorting-Complex-Required-For-Transport-(ESCRT) 30 7.64e-03 4.20e-02 0.22900 0.225000 4.12e-02 3.28e-02 6.96e-01
TICAM1-dependent-activation-of-IRF3/IRF7 12 4.04e-01 5.94e-01 0.22900 0.107000 2.02e-01 5.22e-01 2.25e-01
Effects-of-PIP2-hydrolysis 23 4.49e-02 1.54e-01 0.22800 -0.220000 -5.90e-02 6.73e-02 6.24e-01
Signaling-by-EGFR 45 3.35e-02 1.24e-01 0.22800 0.202000 1.06e-01 1.91e-02 2.20e-01
Gastrin-CREB-signalling-pathway-via-PKC-and-MAPK 16 2.50e-01 4.48e-01 0.22800 0.207000 9.55e-02 1.52e-01 5.08e-01
RNA-Polymerase-I-Promoter-Escape 32 1.95e-01 3.91e-01 0.22800 -0.183000 -1.35e-01 7.27e-02 1.86e-01
Assembly-and-cell-surface-presentation-of-NMDA-receptors 16 4.85e-01 6.58e-01 0.22700 0.173000 1.47e-01 2.30e-01 3.09e-01
Long-term-potentiation 16 6.49e-02 1.95e-01 0.22700 0.224000 3.34e-02 1.21e-01 8.17e-01
Regulation-of-KIT-signaling 15 1.14e-01 2.83e-01 0.22600 0.050200 2.21e-01 7.37e-01 1.39e-01
Uptake-and-actions-of-bacterial-toxins 23 3.53e-01 5.47e-01 0.22600 0.144000 1.74e-01 2.30e-01 1.49e-01
Synthesis-of-active-ubiquitin:-roles-of-E1-and-E2-enzymes 29 3.25e-03 2.07e-02 0.22500 -0.014700 -2.25e-01 8.91e-01 3.62e-02
Formation-of-the-Early-Elongation-Complex 33 1.86e-01 3.81e-01 0.22500 -0.183000 -1.32e-01 6.97e-02 1.90e-01
Formation-of-the-HIV-1-Early-Elongation-Complex 33 1.86e-01 3.81e-01 0.22500 -0.183000 -1.32e-01 6.97e-02 1.90e-01
Class-B/2-(Secretin-family-receptors) 46 8.16e-02 2.30e-01 0.22400 0.186000 1.25e-01 2.92e-02 1.42e-01
Tie2-Signaling 17 4.92e-01 6.61e-01 0.22400 -0.162000 -1.54e-01 2.47e-01 2.70e-01
Visual-phototransduction 54 7.82e-02 2.24e-01 0.22300 0.136000 1.77e-01 8.44e-02 2.43e-02
N-Glycan-antennae-elongation 13 1.99e-01 3.95e-01 0.22300 0.215000 6.13e-02 1.80e-01 7.02e-01
PI-3K-cascade:FGFR1 11 1.94e-01 3.91e-01 0.22300 -0.043400 -2.18e-01 8.03e-01 2.10e-01
PECAM1-interactions 11 4.50e-01 6.31e-01 0.22300 0.103000 1.97e-01 5.55e-01 2.57e-01
Signaling-by-TGF-beta-family-members 88 1.19e-03 9.19e-03 0.22200 0.199000 9.81e-02 1.25e-03 1.12e-01
Blood-group-systems-biosynthesis 11 2.78e-01 4.84e-01 0.22200 0.212000 6.57e-02 2.23e-01 7.06e-01
RNA-Polymerase-I-Transcription-Termination 30 1.75e-01 3.69e-01 0.22100 -0.188000 -1.17e-01 7.53e-02 2.69e-01
Metabolism-of-polyamines 53 1.43e-03 1.08e-02 0.22100 -0.213000 -5.86e-02 7.45e-03 4.61e-01
InlB-mediated-entry-of-Listeria-monocytogenes-into-host-cell 13 5.76e-01 7.20e-01 0.22000 0.168000 1.43e-01 2.95e-01 3.73e-01
Autodegradation-of-Cdh1-by-Cdh1:APC/C 60 1.41e-02 6.49e-02 0.22000 -0.195000 -1.02e-01 8.87e-03 1.74e-01
SHC1-events-in-ERBB2-signaling 21 2.91e-01 4.99e-01 0.21900 0.187000 1.14e-01 1.37e-01 3.65e-01
Signaling-by-Rho-GTPases 340 1.22e-06 2.65e-05 0.21900 0.146000 1.64e-01 3.89e-06 2.40e-07
Synthesis-of-bile-acids-and-bile-salts 22 3.38e-01 5.36e-01 0.21900 -0.127000 -1.79e-01 3.03e-01 1.46e-01
p53-Dependent-G1-DNA-Damage-Response 59 9.94e-04 8.00e-03 0.21900 -0.210000 -6.14e-02 5.29e-03 4.15e-01
p53-Dependent-G1/S-DNA-damage-checkpoint 59 9.94e-04 8.00e-03 0.21900 -0.210000 -6.14e-02 5.29e-03 4.15e-01
Apoptotic-execution-phase 41 3.03e-02 1.15e-01 0.21900 0.201000 8.66e-02 2.63e-02 3.38e-01
Dectin-2-family 11 5.72e-01 7.18e-01 0.21800 0.180000 1.24e-01 3.01e-01 4.78e-01
Paradoxical-activation-of-RAF-signaling-by-kinase-inactive-BRAF 39 1.81e-01 3.75e-01 0.21800 0.171000 1.36e-01 6.45e-02 1.43e-01
Signaling-by-RAS-mutants 39 1.81e-01 3.75e-01 0.21800 0.171000 1.36e-01 6.45e-02 1.43e-01
Signaling-by-moderate-kinase-activity-BRAF-mutants 39 1.81e-01 3.75e-01 0.21800 0.171000 1.36e-01 6.45e-02 1.43e-01
Signaling-downstream-of-RAS-mutants 39 1.81e-01 3.75e-01 0.21800 0.171000 1.36e-01 6.45e-02 1.43e-01
SCF(Skp2)-mediated-degradation-of-p27/p21 57 2.76e-03 1.79e-02 0.21800 -0.206000 -7.12e-02 7.12e-03 3.53e-01
RHO-GTPases-Activate-Formins 110 1.35e-02 6.33e-02 0.21800 0.154000 1.55e-01 5.44e-03 5.08e-03
SLBP-Dependent-Processing-of-Replication-Dependent-Histone-Pre-mRNAs 10 2.15e-01 4.14e-01 0.21800 -0.034900 -2.15e-01 8.48e-01 2.39e-01
Activation-of-HOX-genes-during-differentiation 51 1.10e-01 2.75e-01 0.21800 -0.136000 -1.70e-01 9.26e-02 3.58e-02
Activation-of-anterior-HOX-genes-in-hindbrain-development-during-early-embryogenesis 51 1.10e-01 2.75e-01 0.21800 -0.136000 -1.70e-01 9.26e-02 3.58e-02
Regulation-of-IFNA-signaling 12 1.49e-01 3.35e-01 0.21800 0.031300 2.15e-01 8.51e-01 1.96e-01
Metabolism-of-vitamins-and-cofactors 153 2.20e-03 1.51e-02 0.21800 -0.145000 -1.63e-01 2.06e-03 5.27e-04
FOXO-mediated-transcription-of-cell-cycle-genes 14 2.24e-02 9.20e-02 0.21700 0.043700 -2.13e-01 7.77e-01 1.68e-01
Constitutive-Signaling-by-Aberrant-PI3K-in-Cancer 54 1.22e-01 2.96e-01 0.21600 0.158000 1.48e-01 4.47e-02 6.08e-02
Protein-protein-interactions-at-synapses 61 1.93e-02 8.18e-02 0.21600 0.190000 1.03e-01 1.05e-02 1.64e-01
DAP12-interactions 25 3.80e-01 5.73e-01 0.21600 0.149000 1.56e-01 1.97e-01 1.77e-01
FRS-mediated-FGFR1-signaling 13 2.38e-01 4.37e-01 0.21600 -0.063300 -2.06e-01 6.93e-01 1.98e-01
NRAGE-signals-death-through-JNK 55 6.32e-02 1.94e-01 0.21600 0.121000 1.79e-01 1.22e-01 2.20e-02
Scavenging-by-Class-A-Receptors 16 5.42e-01 6.95e-01 0.21500 0.154000 1.50e-01 2.86e-01 3.00e-01
Platelet-activation,-signaling-and-aggregation 214 2.24e-04 2.33e-03 0.21500 0.162000 1.41e-01 4.52e-05 3.93e-04
Smooth-Muscle-Contraction 31 9.21e-03 4.83e-02 0.21300 0.031400 2.11e-01 7.62e-01 4.21e-02
Formation-of-TC-NER-Pre-Incision-Complex 53 1.30e-01 3.13e-01 0.21200 -0.140000 -1.59e-01 7.75e-02 4.48e-02
Asymmetric-localization-of-PCP-proteins 60 1.78e-02 7.65e-02 0.21000 -0.188000 -9.46e-02 1.19e-02 2.05e-01
Signaling-by-NOTCH4 78 4.53e-03 2.78e-02 0.21000 -0.189000 -9.23e-02 3.95e-03 1.59e-01
Cellular-response-to-heat-stress 91 3.22e-02 1.20e-01 0.21000 -0.158000 -1.37e-01 9.07e-03 2.36e-02
Signal-amplification 23 1.60e-01 3.51e-01 0.21000 0.193000 8.21e-02 1.09e-01 4.95e-01
Cell-Cell-communication 83 4.50e-02 1.54e-01 0.20900 0.138000 1.57e-01 3.01e-02 1.33e-02
Mitotic-Telophase/Cytokinesis 13 1.62e-01 3.53e-01 0.20900 0.206000 3.40e-02 1.99e-01 8.32e-01
HDR-through-MMEJ-(alt-NHEJ) 10 5.97e-01 7.33e-01 0.20900 -0.111000 -1.77e-01 5.45e-01 3.33e-01
L1CAM-interactions 82 1.16e-02 5.72e-02 0.20800 0.179000 1.06e-01 5.12e-03 9.69e-02
Resolution-of-Sister-Chromatid-Cohesion 95 1.20e-02 5.83e-02 0.20700 0.172000 1.16e-01 3.79e-03 5.18e-02
EML4-and-NUDC-in-mitotic-spindle-formation 87 2.89e-02 1.11e-01 0.20700 0.165000 1.25e-01 7.97e-03 4.37e-02
Gene-Silencing-by-RNA 63 1.05e-01 2.65e-01 0.20600 -0.152000 -1.39e-01 3.66e-02 5.65e-02
RHO-GTPases-activate-PKNs 31 3.20e-01 5.22e-01 0.20600 0.135000 1.56e-01 1.94e-01 1.33e-01
Cyclin-A/B1/B2-associated-events-during-G2/M-transition 23 4.22e-01 6.06e-01 0.20600 0.132000 1.58e-01 2.73e-01 1.90e-01
Lysosome-Vesicle-Biogenesis 28 3.72e-01 5.64e-01 0.20600 0.140000 1.50e-01 1.99e-01 1.68e-01
Activation-of-PPARGC1A-(PGC-1alpha)-by-phosphorylation 10 4.76e-01 6.53e-01 0.20500 -0.082500 -1.88e-01 6.51e-01 3.03e-01
G1/S-Specific-Transcription 27 3.83e-01 5.74e-01 0.20500 0.152000 1.38e-01 1.72e-01 2.15e-01
Signaling-by-BRAF-and-RAF-fusions 57 4.13e-02 1.48e-01 0.20500 0.179000 1.01e-01 1.98e-02 1.87e-01
G1/S-DNA-Damage-Checkpoints 61 1.77e-03 1.29e-02 0.20500 -0.197000 -5.66e-02 7.84e-03 4.45e-01
ERBB2-Activates-PTK6-Signaling 12 5.47e-01 6.97e-01 0.20500 0.174000 1.08e-01 2.97e-01 5.19e-01
Downstream-signaling-of-activated-FGFR2 21 1.21e-01 2.95e-01 0.20400 -0.058900 -1.96e-01 6.41e-01 1.20e-01
Downstream-TCR-signaling 77 5.45e-03 3.23e-02 0.20400 -0.185000 -8.74e-02 5.10e-03 1.85e-01
Orc1-removal-from-chromatin 66 9.92e-05 1.22e-03 0.20300 -0.201000 -2.76e-02 4.76e-03 6.98e-01
Thrombin-signalling-through-proteinase-activated-receptors-(PARs) 22 1.85e-01 3.81e-01 0.20200 0.187000 7.70e-02 1.29e-01 5.32e-01
Golgi-Cisternae-Pericentriolar-Stack-Reorganization 13 4.24e-02 1.50e-01 0.20200 0.197000 -4.70e-02 2.20e-01 7.69e-01
Bile-acid-and-bile-salt-metabolism 25 4.11e-01 5.97e-01 0.20200 -0.131000 -1.54e-01 2.58e-01 1.83e-01
PTEN-Regulation 135 1.10e-02 5.52e-02 0.20200 -0.142000 -1.43e-01 4.35e-03 4.22e-03
Pentose-phosphate-pathway 12 1.75e-01 3.69e-01 0.20100 0.200000 2.22e-02 2.30e-01 8.94e-01
Norepinephrine-Neurotransmitter-Release-Cycle 12 6.18e-01 7.41e-01 0.20100 0.119000 1.62e-01 4.77e-01 3.31e-01
Synthesis,-secretion,-and-deacylation-of-Ghrelin 11 1.98e-01 3.95e-01 0.20000 0.199000 1.97e-02 2.52e-01 9.10e-01
Regulation-of-HSF1-mediated-heat-shock-response 76 7.47e-02 2.16e-01 0.19900 -0.150000 -1.31e-01 2.34e-02 4.88e-02
Formation-of-Fibrin-Clot-(Clotting-Cascade) 18 3.45e-01 5.40e-01 0.19900 0.090700 1.77e-01 5.06e-01 1.93e-01
Regulation-of-RAS-by-GAPs 63 1.17e-03 9.04e-03 0.19800 -0.193000 -4.70e-02 8.17e-03 5.19e-01
Regulation-of-localization-of-FOXO-transcription-factors 12 6.03e-01 7.34e-01 0.19800 -0.112000 -1.64e-01 5.03e-01 3.26e-01
Regulation-of-mRNA-stability-by-proteins-that-bind-AU-rich-elements 83 3.05e-03 1.95e-02 0.19800 -0.182000 -7.82e-02 4.26e-03 2.19e-01
Competing-endogenous-RNAs-(ceRNAs)-regulate-PTEN-translation 10 6.88e-01 7.91e-01 0.19800 -0.119000 -1.57e-01 5.14e-01 3.89e-01
MAPK-targets/-Nuclear-events-mediated-by-MAP-kinases 30 3.27e-02 1.22e-01 0.19700 -0.040400 -1.93e-01 7.02e-01 6.76e-02
Interleukin-12-family-signaling 37 2.80e-02 1.09e-01 0.19700 0.189000 5.37e-02 4.65e-02 5.72e-01
Nucleotide-binding-domain,-leucine-rich-repeat-containing-receptor-(NLR)-signaling-pathways 45 2.29e-01 4.27e-01 0.19600 0.131000 1.47e-01 1.30e-01 8.89e-02
Autophagy 110 8.95e-03 4.73e-02 0.19600 -0.108000 -1.64e-01 5.14e-02 2.97e-03
Transcriptional-Regulation-by-MECP2 46 6.42e-02 1.95e-01 0.19600 -0.086900 -1.76e-01 3.08e-01 3.90e-02
Processive-synthesis-on-the-lagging-strand 14 1.07e-01 2.68e-01 0.19600 0.005410 1.96e-01 9.72e-01 2.04e-01
Activation-of-NF-kappaB-in-B-cells 62 1.68e-03 1.25e-02 0.19600 -0.190000 -4.75e-02 9.72e-03 5.18e-01
Listeria-monocytogenes-entry-into-host-cells 16 5.88e-01 7.27e-01 0.19500 0.148000 1.27e-01 3.04e-01 3.79e-01
SHC-mediated-cascade:FGFR4 12 5.38e-01 6.93e-01 0.19500 -0.095000 -1.70e-01 5.69e-01 3.07e-01
RAF-independent-MAPK1/3-activation 21 4.55e-01 6.34e-01 0.19400 0.157000 1.15e-01 2.13e-01 3.63e-01
Transcription-of-E2F-targets-under-negative-control-by-p107-(RBL1)-and-p130-(RBL2)-in-complex-with-HDAC1 15 3.04e-01 5.11e-01 0.19400 0.183000 6.56e-02 2.21e-01 6.60e-01
Regulation-of-PTEN-mRNA-translation 11 6.04e-01 7.34e-01 0.19400 -0.101000 -1.66e-01 5.61e-01 3.42e-01
Signaling-by-TGF-beta-Receptor-Complex 71 2.37e-03 1.60e-02 0.19400 0.184000 6.02e-02 7.28e-03 3.81e-01
Regulation-of-MECP2-expression-and-activity 28 2.05e-01 4.04e-01 0.19400 -0.087500 -1.73e-01 4.23e-01 1.14e-01
VLDLR-internalisation-and-degradation 11 4.65e-02 1.57e-01 0.19400 0.098700 -1.66e-01 5.71e-01 3.39e-01
IRAK2-mediated-activation-of-TAK1-complex-upon-TLR7/8-or-9-stimulation 14 4.98e-01 6.64e-01 0.19400 0.168000 9.53e-02 2.75e-01 5.37e-01
TRAF6-mediated-induction-of-TAK1-complex-within-TLR4-complex 14 4.98e-01 6.64e-01 0.19400 0.168000 9.53e-02 2.75e-01 5.37e-01
RAF-activation 29 3.94e-01 5.85e-01 0.19300 -0.126000 -1.46e-01 2.40e-01 1.74e-01
SHC1-events-in-ERBB4-signaling 13 4.48e-01 6.31e-01 0.19300 0.175000 8.09e-02 2.75e-01 6.13e-01
Host-Interactions-of-HIV-factors 114 2.21e-02 9.10e-02 0.19200 -0.150000 -1.20e-01 5.75e-03 2.65e-02
CDK-mediated-phosphorylation-and-removal-of-Cdc6 66 1.82e-02 7.77e-02 0.19200 -0.174000 -8.07e-02 1.47e-02 2.57e-01
Olfactory-Signaling-Pathway 16 2.43e-01 4.41e-01 0.19200 0.055100 1.83e-01 7.03e-01 2.04e-01
Peptide-hormone-metabolism 51 2.32e-02 9.42e-02 0.19100 0.179000 6.78e-02 2.71e-02 4.03e-01
Trafficking-of-GluR2-containing-AMPA-receptors 15 5.09e-01 6.73e-01 0.19100 0.099100 1.64e-01 5.06e-01 2.72e-01
Establishment-of-Sister-Chromatid-Cohesion 10 7.85e-02 2.24e-01 0.19100 0.175000 -7.72e-02 3.38e-01 6.73e-01
Interleukin-20-family-signaling 14 6.13e-01 7.38e-01 0.19100 -0.116000 -1.52e-01 4.53e-01 3.24e-01
CD28-dependent-Vav1-pathway 11 7.13e-01 8.08e-01 0.19100 0.129000 1.41e-01 4.58e-01 4.18e-01
RA-biosynthesis-pathway 13 6.14e-01 7.38e-01 0.19100 -0.110000 -1.56e-01 4.91e-01 3.30e-01
Metabolism-of-lipids 575 1.26e-10 4.72e-09 0.19100 -0.104000 -1.60e-01 2.19e-05 7.10e-11
Abortive-elongation-of-HIV-1-transcript-in-the-absence-of-Tat 23 8.90e-02 2.38e-01 0.19100 -0.187000 -4.06e-02 1.22e-01 7.36e-01
Factors-involved-in-megakaryocyte-development-and-platelet-production 104 2.57e-02 1.02e-01 0.19100 0.153000 1.14e-01 7.14e-03 4.51e-02
Viral-Messenger-RNA-Synthesis 43 2.73e-01 4.80e-01 0.19000 -0.139000 -1.30e-01 1.15e-01 1.40e-01
Amplification--of-signal-from-unattached--kinetochores-via-a-MAD2--inhibitory-signal 83 6.61e-02 1.98e-01 0.19000 0.148000 1.19e-01 1.98e-02 6.06e-02
Amplification-of-signal-from-the-kinetochores 83 6.61e-02 1.98e-01 0.19000 0.148000 1.19e-01 1.98e-02 6.06e-02
RNA-Polymerase-I-Transcription-Initiation 46 2.53e-01 4.52e-01 0.19000 -0.135000 -1.34e-01 1.14e-01 1.15e-01
Transport-of-Mature-mRNA-derived-from-an-Intron-Containing-Transcript 70 1.17e-01 2.87e-01 0.19000 -0.126000 -1.42e-01 6.80e-02 3.99e-02
p75-NTR-receptor-mediated-signalling 90 5.70e-02 1.83e-01 0.19000 0.122000 1.46e-01 4.64e-02 1.68e-02
Tight-junction-interactions 11 4.50e-02 1.54e-01 0.19000 0.146000 -1.21e-01 4.01e-01 4.87e-01
Depolymerisation-of-the-Nuclear-Lamina 15 5.72e-01 7.17e-01 0.18900 0.155000 1.08e-01 2.99e-01 4.68e-01
Neddylation 210 2.19e-03 1.51e-02 0.18900 -0.135000 -1.32e-01 7.60e-04 1.01e-03
Regulation-of-cholesterol-biosynthesis-by-SREBP-(SREBF) 53 3.44e-02 1.27e-01 0.18900 -0.074600 -1.73e-01 3.48e-01 2.93e-02
MHC-class-II-antigen-presentation 82 1.72e-02 7.47e-02 0.18900 0.166000 8.99e-02 9.51e-03 1.60e-01
Neurexins-and-neuroligins 38 2.58e-01 4.59e-01 0.18700 0.152000 1.08e-01 1.05e-01 2.48e-01
Hemostasis 440 2.40e-06 4.72e-05 0.18700 0.142000 1.21e-01 3.95e-07 1.39e-05
Oncogenic-MAPK-signaling 64 5.60e-02 1.81e-01 0.18600 0.161000 9.32e-02 2.56e-02 1.98e-01
Assembly-of-the-pre-replicative-complex 64 6.67e-05 9.17e-04 0.18600 -0.186000 -3.35e-04 9.99e-03 9.96e-01
Nuclear-Events-(kinase-and-transcription-factor-activation) 24 9.35e-02 2.44e-01 0.18600 -0.040700 -1.82e-01 7.30e-01 1.23e-01
Rho-GTPase-cycle 130 1.17e-02 5.73e-02 0.18600 0.110000 1.50e-01 3.09e-02 3.12e-03
Degradation-of-beta-catenin-by-the-destruction-complex 81 2.28e-02 9.29e-02 0.18600 -0.163000 -9.06e-02 1.15e-02 1.59e-01
Growth-hormone-receptor-signaling 20 4.45e-01 6.30e-01 0.18600 -0.157000 -9.92e-02 2.24e-01 4.43e-01
Immunoregulatory-interactions-between-a-Lymphoid-and-a-non-Lymphoid-cell 40 3.14e-01 5.19e-01 0.18600 0.137000 1.26e-01 1.35e-01 1.69e-01
Sphingolipid-de-novo-biosynthesis 33 2.78e-01 4.84e-01 0.18600 0.155000 1.01e-01 1.22e-01 3.14e-01
Striated-Muscle-Contraction 27 1.92e-01 3.90e-01 0.18500 0.073400 1.70e-01 5.09e-01 1.27e-01
Surfactant-metabolism 15 6.41e-01 7.51e-01 0.18400 0.140000 1.19e-01 3.47e-01 4.25e-01
Condensation-of-Prophase-Chromosomes 14 6.37e-01 7.51e-01 0.18400 0.112000 1.46e-01 4.69e-01 3.44e-01
Pre-NOTCH-Processing-in-Golgi 16 1.52e-01 3.39e-01 0.18400 -0.022600 -1.82e-01 8.75e-01 2.07e-01
ERBB2-Regulates-Cell-Motility 14 4.14e-01 6.00e-01 0.18300 0.170000 6.97e-02 2.72e-01 6.52e-01
Biological-oxidations 111 4.52e-02 1.54e-01 0.18300 -0.134000 -1.25e-01 1.49e-02 2.29e-02
tRNA-processing-in-the-nucleus 56 1.97e-01 3.94e-01 0.18300 -0.118000 -1.39e-01 1.26e-01 7.22e-02
Metabolism-of-nucleotides 83 6.94e-02 2.04e-01 0.18300 -0.146000 -1.09e-01 2.16e-02 8.49e-02
APC/C:Cdh1-mediated-degradation-of-Cdc20-and-other-APC/C:Cdh1-targeted-proteins-in-late-mitosis/early-G1 67 2.07e-02 8.67e-02 0.18200 -0.167000 -7.39e-02 1.83e-02 2.96e-01
Mitotic-Spindle-Checkpoint 98 2.73e-02 1.07e-01 0.18100 0.152000 9.91e-02 9.52e-03 9.05e-02
Transcriptional-regulation-by-small-RNAs 46 2.84e-01 4.91e-01 0.18100 -0.123000 -1.33e-01 1.49e-01 1.20e-01
Phase-II---Conjugation-of-compounds 52 2.49e-01 4.46e-01 0.18000 -0.125000 -1.29e-01 1.19e-01 1.07e-01
Signaling-by-Receptor-Tyrosine-Kinases 390 1.34e-06 2.82e-05 0.17900 0.149000 9.92e-02 4.50e-07 8.10e-04
Metabolism-of-non-coding-RNA 51 2.23e-01 4.21e-01 0.17900 -0.112000 -1.40e-01 1.68e-01 8.33e-02
snRNP-Assembly 51 2.23e-01 4.21e-01 0.17900 -0.112000 -1.40e-01 1.68e-01 8.33e-02
The-role-of-GTSE1-in-G2/M-progression-after-G2-checkpoint 55 1.73e-03 1.27e-02 0.17900 -0.178000 -1.90e-02 2.23e-02 8.08e-01
GRB2-events-in-ERBB2-signaling 15 4.14e-01 6.00e-01 0.17900 0.165000 6.92e-02 2.69e-01 6.43e-01
Cytochrome-c-mediated-apoptotic-response 12 5.46e-01 6.96e-01 0.17900 -0.078200 -1.61e-01 6.39e-01 3.35e-01
Metabolism-of-RNA 619 1.46e-07 3.67e-06 0.17800 -0.129000 -1.23e-01 4.75e-08 2.26e-07
UCH-proteinases 80 9.06e-04 7.42e-03 0.17800 -0.173000 -4.07e-02 7.49e-03 5.30e-01
TRAF6-mediated-IRF7-activation 14 5.50e-02 1.79e-01 0.17800 -0.058900 1.68e-01 7.03e-01 2.77e-01
TRAF6-mediated-NF-kB-activation 20 1.09e-01 2.72e-01 0.17800 0.021200 1.76e-01 8.70e-01 1.72e-01
Transcriptional-Regulation-by-E2F6 33 3.74e-01 5.67e-01 0.17700 0.141000 1.08e-01 1.62e-01 2.83e-01
DNA-Damage-Recognition-in-GG-NER 38 3.07e-01 5.12e-01 0.17700 -0.143000 -1.05e-01 1.27e-01 2.62e-01
Aggrephagy 18 5.16e-01 6.78e-01 0.17700 0.094700 1.50e-01 4.87e-01 2.71e-01
Regulated-proteolysis-of-p75NTR 11 4.59e-01 6.38e-01 0.17700 0.168000 5.57e-02 3.34e-01 7.49e-01
Cleavage-of-the-damaged-purine 10 7.23e-01 8.15e-01 0.17700 0.102000 1.45e-01 5.76e-01 4.27e-01
Depurination 10 7.23e-01 8.15e-01 0.17700 0.102000 1.45e-01 5.76e-01 4.27e-01
Recognition-and-association-of-DNA-glycosylase-with-site-containing-an-affected-purine 10 7.23e-01 8.15e-01 0.17700 0.102000 1.45e-01 5.76e-01 4.27e-01
Transcriptional-regulation-of-granulopoiesis 28 4.74e-01 6.53e-01 0.17700 0.132000 1.18e-01 2.26e-01 2.81e-01
Regulation-of-RUNX3-expression-and-activity 52 2.51e-03 1.65e-02 0.17700 -0.176000 -1.65e-02 2.83e-02 8.37e-01
Downstream-signaling-events-of-B-Cell-Receptor-(BCR) 75 2.67e-02 1.05e-01 0.17700 -0.158000 -7.82e-02 1.78e-02 2.42e-01
Anchoring-of-the-basal-body-to-the-plasma-membrane 96 2.26e-02 9.25e-02 0.17600 0.152000 8.92e-02 1.01e-02 1.31e-01
LDL-clearance 16 2.73e-01 4.81e-01 0.17600 0.170000 4.44e-02 2.39e-01 7.58e-01
Influenza-Life-Cycle 110 5.05e-02 1.68e-01 0.17500 -0.111000 -1.35e-01 4.37e-02 1.46e-02
Formation-of-tubulin-folding-intermediates-by-CCT/TriC 20 8.88e-02 2.38e-01 0.17500 0.009930 1.75e-01 9.39e-01 1.76e-01
Cell-junction-organization 57 1.67e-01 3.60e-01 0.17500 0.143000 1.01e-01 6.23e-02 1.88e-01
Formation-of-HIV-elongation-complex-in-the-absence-of-HIV-Tat 43 3.06e-01 5.12e-01 0.17500 -0.136000 -1.10e-01 1.24e-01 2.13e-01
Meiotic-synapsis 23 3.94e-01 5.85e-01 0.17400 0.152000 8.58e-02 2.08e-01 4.76e-01
Signaling-by-Non-Receptor-Tyrosine-Kinases 52 8.64e-02 2.35e-01 0.17400 0.156000 7.72e-02 5.14e-02 3.36e-01
Signaling-by-PTK6 52 8.64e-02 2.35e-01 0.17400 0.156000 7.72e-02 5.14e-02 3.36e-01
Transport-of-the-SLBP-independent-Mature-mRNA 34 3.24e-01 5.27e-01 0.17400 -0.096800 -1.45e-01 3.29e-01 1.44e-01
Regulation-of-PTEN-gene-transcription 59 4.45e-03 2.74e-02 0.17400 -0.033100 -1.71e-01 6.61e-01 2.33e-02
Cargo-trafficking-to-the-periciliary-membrane 46 2.86e-01 4.92e-01 0.17400 0.110000 1.35e-01 1.98e-01 1.14e-01
APC/C:Cdc20-mediated-degradation-of-Cyclin-B 22 1.96e-01 3.93e-01 0.17400 0.167000 4.88e-02 1.76e-01 6.92e-01
Diseases-of-metabolism 70 1.75e-01 3.69e-01 0.17400 -0.122000 -1.23e-01 7.74e-02 7.42e-02
Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S 47 5.43e-02 1.77e-01 0.17400 -0.060200 -1.63e-01 4.75e-01 5.35e-02
Cyclin-E-associated-events-during-G1/S-transition 79 4.84e-02 1.62e-01 0.17400 -0.150000 -8.77e-02 2.15e-02 1.78e-01
Mismatch-repair-(MMR)-directed-by-MSH2:MSH6-(MutSalpha) 11 3.15e-01 5.19e-01 0.17300 -0.172000 -2.13e-02 3.23e-01 9.03e-01
Mismatch-Repair 12 5.70e-01 7.17e-01 0.17300 -0.155000 -7.62e-02 3.52e-01 6.48e-01
TP53-regulates-transcription-of-several-additional-cell-death-genes-whose-specific-roles-in-p53-dependent-apoptosis-remain-uncertain 11 2.72e-01 4.80e-01 0.17300 0.009720 1.73e-01 9.55e-01 3.21e-01
Translation-initiation-complex-formation 46 4.36e-02 1.52e-01 0.17300 -0.053200 -1.64e-01 5.32e-01 5.39e-02
Regulation-of-expression-of-SLITs-and-ROBOs 125 4.35e-02 1.52e-01 0.17200 -0.129000 -1.15e-01 1.32e-02 2.68e-02
Regulation-of-TP53-Activity-through-Association-with-Co-factors 11 5.55e-01 7.04e-01 0.17200 -0.158000 -6.78e-02 3.63e-01 6.97e-01
Synthesis-of-substrates-in-N-glycan-biosythesis 56 3.48e-03 2.19e-02 0.17200 0.171000 2.30e-02 2.73e-02 7.66e-01
Influenza-Viral-RNA-Transcription-and-Replication 102 7.67e-02 2.21e-01 0.17200 -0.113000 -1.29e-01 4.85e-02 2.43e-02
Inactivation-of-APC/C-via-direct-inhibition-of-the-APC/C-complex 18 2.15e-01 4.14e-01 0.17100 0.168000 3.58e-02 2.18e-01 7.92e-01
Inhibition-of-the-proteolytic-activity-of-APC/C-required-for-the-onset-of-anaphase-by-mitotic-spindle-checkpoint-components 18 2.15e-01 4.14e-01 0.17100 0.168000 3.58e-02 2.18e-01 7.92e-01
ER-Phagosome-pathway 73 5.67e-04 4.97e-03 0.17000 -0.169000 -1.98e-02 1.25e-02 7.70e-01
Transport-of-the-SLBP-Dependant-Mature-mRNA 35 3.38e-01 5.36e-01 0.17000 -0.096000 -1.41e-01 3.26e-01 1.50e-01
Interleukin-6-signaling 10 2.78e-01 4.84e-01 0.17000 0.170000 -1.60e-03 3.51e-01 9.93e-01
Cdc20:Phospho-APC/C-mediated-degradation-of-Cyclin-A 65 2.91e-02 1.12e-01 0.17000 -0.157000 -6.38e-02 2.85e-02 3.74e-01
BBSome-mediated-cargo-targeting-to-cilium 21 4.56e-01 6.36e-01 0.16900 0.084400 1.47e-01 5.03e-01 2.45e-01
Cyclin-A:Cdk2-associated-events-at-S-phase-entry 81 4.57e-02 1.56e-01 0.16900 -0.147000 -8.27e-02 2.21e-02 1.98e-01
G0-and-Early-G1 25 3.50e-01 5.46e-01 0.16900 0.150000 7.77e-02 1.94e-01 5.02e-01
ERK/MAPK-targets 21 8.82e-02 2.37e-01 0.16900 -0.006700 -1.68e-01 9.58e-01 1.82e-01
Intra-Golgi-traffic 41 5.73e-03 3.32e-02 0.16800 0.168000 -2.91e-03 6.30e-02 9.74e-01
Selenoamino-acid-metabolism 76 1.69e-01 3.62e-01 0.16800 -0.115000 -1.22e-01 8.32e-02 6.57e-02
Mitotic-Prometaphase 174 1.97e-03 1.39e-02 0.16800 0.145000 8.42e-02 1.00e-03 5.59e-02
Cell-death-signalling-via-NRAGE,-NRIF-and-NADE 72 1.40e-01 3.27e-01 0.16700 0.099800 1.34e-01 1.44e-01 4.90e-02
Budding-and-maturation-of-HIV-virion 25 8.35e-02 2.32e-01 0.16700 0.166000 1.91e-02 1.51e-01 8.69e-01
Transcription-of-the-HIV-genome 66 2.08e-01 4.08e-01 0.16700 -0.110000 -1.26e-01 1.24e-01 7.78e-02
Selenocysteine-synthesis 61 2.12e-01 4.13e-01 0.16600 -0.103000 -1.30e-01 1.63e-01 7.85e-02
Inwardly-rectifying-K+-channels 20 5.61e-01 7.10e-01 0.16500 -0.136000 -9.39e-02 2.92e-01 4.67e-01
CDC6-association-with-the-ORC:origin-complex 11 4.51e-01 6.31e-01 0.16500 0.040800 1.60e-01 8.15e-01 3.59e-01
trans-Golgi-Network-Vesicle-Budding 64 1.57e-01 3.47e-01 0.16400 0.136000 9.26e-02 6.03e-02 2.00e-01
Diseases-associated-with-N-glycosylation-of-proteins 16 4.19e-02 1.48e-01 0.16400 0.144000 -7.99e-02 3.20e-01 5.80e-01
Constitutive-Signaling-by-EGFRvIII 14 3.59e-01 5.51e-01 0.16400 -0.039200 -1.59e-01 8.00e-01 3.02e-01
Signaling-by-EGFRvIII-in-Cancer 14 3.59e-01 5.51e-01 0.16400 -0.039200 -1.59e-01 8.00e-01 3.02e-01
Signaling-by-NTRK3-(TRKC) 17 6.43e-01 7.52e-01 0.16400 0.131000 9.83e-02 3.50e-01 4.83e-01
Conversion-from-APC/C:Cdc20-to-APC/C:Cdh1-in-late-anaphase 18 9.60e-02 2.48e-01 0.16400 0.163000 -1.18e-02 2.31e-01 9.31e-01
Deregulated-CDK5-triggers-multiple-neurodegenerative-pathways-in-Alzheimer's-disease-models 18 2.34e-01 4.32e-01 0.16400 0.161000 3.16e-02 2.38e-01 8.17e-01
Neurodegenerative-Diseases 18 2.34e-01 4.32e-01 0.16400 0.161000 3.16e-02 2.38e-01 8.17e-01
Metabolism-of-steroid-hormones 13 2.06e-01 4.05e-01 0.16300 0.163000 -5.00e-03 3.09e-01 9.75e-01
Eukaryotic-Translation-Elongation 61 2.01e-01 3.98e-01 0.16300 -0.096400 -1.32e-01 1.93e-01 7.57e-02
Diseases-associated-with-glycosylation-precursor-biosynthesis 18 7.77e-02 2.23e-01 0.16300 0.023800 -1.61e-01 8.61e-01 2.38e-01
FOXO-mediated-transcription-of-oxidative-stress,-metabolic-and-neuronal-genes 23 9.53e-03 4.97e-02 0.16200 0.095500 -1.31e-01 4.28e-01 2.77e-01
Lewis-blood-group-biosynthesis 10 6.27e-01 7.46e-01 0.16200 0.149000 6.42e-02 4.16e-01 7.25e-01
Disorders-of-transmembrane-transporters 131 4.34e-02 1.52e-01 0.16200 -0.127000 -1.00e-01 1.23e-02 4.79e-02
Transcriptional-regulation-by-the-AP-2-(TFAP2)-family-of-transcription-factors 24 5.65e-01 7.13e-01 0.16100 0.126000 1.01e-01 2.85e-01 3.92e-01
Pre-NOTCH-Expression-and-Processing 47 1.91e-01 3.89e-01 0.16100 0.141000 7.84e-02 9.48e-02 3.53e-01
Regulation-of-gene-expression-in-late-stage-(branching-morphogenesis)-pancreatic-bud-precursor-cells 12 7.64e-01 8.40e-01 0.16100 0.122000 1.06e-01 4.65e-01 5.26e-01
AURKA-Activation-by-TPX2 71 6.19e-02 1.92e-01 0.16100 0.144000 7.26e-02 3.63e-02 2.91e-01
RUNX3-regulates-NOTCH-signaling 14 7.41e-01 8.26e-01 0.16100 0.113000 1.15e-01 4.66e-01 4.57e-01
Glutamate-and-glutamine-metabolism 10 6.04e-01 7.34e-01 0.16000 -0.058300 -1.49e-01 7.50e-01 4.14e-01
Interactions-of-Vpr-with-host-cellular-proteins 33 3.30e-01 5.31e-01 0.16000 -0.079400 -1.39e-01 4.30e-01 1.68e-01
HATs-acetylate-histones 76 6.68e-02 2.00e-01 0.16000 -0.075900 -1.40e-01 2.53e-01 3.45e-02
Transport-of-Ribonucleoproteins-into-the-Host-Nucleus 31 2.77e-01 4.83e-01 0.15900 -0.067700 -1.44e-01 5.14e-01 1.65e-01
Late-endosomal-microautophagy 28 2.45e-01 4.43e-01 0.15900 0.148000 5.72e-02 1.74e-01 6.00e-01
Negative-regulation-of-FGFR3-signaling 23 6.06e-01 7.35e-01 0.15900 -0.104000 -1.20e-01 3.88e-01 3.19e-01
Telomere-C-strand-(Lagging-Strand)-Synthesis 23 3.02e-01 5.10e-01 0.15900 0.054800 1.49e-01 6.49e-01 2.16e-01
Constitutive-Signaling-by-Ligand-Responsive-EGFR-Cancer-Variants 18 3.92e-01 5.84e-01 0.15900 -0.054600 -1.49e-01 6.88e-01 2.75e-01
Signaling-by-Ligand-Responsive-EGFR-Variants-in-Cancer 18 3.92e-01 5.84e-01 0.15900 -0.054600 -1.49e-01 6.88e-01 2.75e-01
Activation-of-ATR-in-response-to-replication-stress 36 6.44e-02 1.95e-01 0.15800 0.030100 1.56e-01 7.55e-01 1.06e-01
CLEC7A-(Dectin-1)-induces-NFAT-activation 11 7.84e-01 8.49e-01 0.15800 -0.121000 -1.02e-01 4.86e-01 5.59e-01
Removal-of-the-Flap-Intermediate 13 1.91e-01 3.89e-01 0.15800 -0.016100 1.58e-01 9.20e-01 3.25e-01
SUMOylation-of-SUMOylation-proteins 34 2.45e-01 4.43e-01 0.15800 -0.066700 -1.43e-01 5.01e-01 1.48e-01
APC/C:Cdc20-mediated-degradation-of-mitotic-proteins 68 3.28e-02 1.22e-01 0.15800 -0.148000 -5.59e-02 3.52e-02 4.25e-01
Viral-mRNA-Translation 58 2.63e-01 4.65e-01 0.15800 -0.097700 -1.24e-01 1.99e-01 1.02e-01
COPI-independent-Golgi-to-ER-retrograde-traffic 31 3.68e-01 5.62e-01 0.15800 0.136000 7.87e-02 1.89e-01 4.49e-01
PI-Metabolism 78 1.61e-02 7.16e-02 0.15700 0.149000 5.23e-02 2.35e-02 4.25e-01
Interleukin-12-signaling 31 3.71e-02 1.35e-01 0.15700 0.157000 1.18e-03 1.30e-01 9.91e-01
TRP-channels 12 1.50e-01 3.37e-01 0.15700 -0.150000 4.78e-02 3.69e-01 7.74e-01
Activation-of-BAD-and-translocation-to-mitochondria 15 5.86e-01 7.27e-01 0.15700 0.139000 7.33e-02 3.51e-01 6.23e-01
EPH-ephrin-mediated-repulsion-of-cells 42 7.83e-02 2.24e-01 0.15600 0.150000 4.32e-02 9.18e-02 6.28e-01
APC:Cdc20-mediated-degradation-of-cell-cycle-proteins-prior-to-satisfation-of-the-cell-cycle-checkpoint 66 3.61e-02 1.33e-01 0.15600 -0.147000 -5.41e-02 3.94e-02 4.47e-01
Phase-I---Functionalization-of-compounds 54 2.75e-01 4.83e-01 0.15600 -0.126000 -9.27e-02 1.11e-01 2.39e-01
Rap1-signalling 14 2.11e-01 4.11e-01 0.15600 0.004800 -1.56e-01 9.75e-01 3.13e-01
Protein-ubiquitination 62 3.31e-04 3.24e-03 0.15600 0.022200 -1.54e-01 7.62e-01 3.60e-02
Global-Genome-Nucleotide-Excision-Repair-(GG-NER) 83 1.71e-01 3.65e-01 0.15600 -0.099800 -1.19e-01 1.16e-01 6.02e-02
Homologous-DNA-Pairing-and-Strand-Exchange 41 1.33e-01 3.16e-01 0.15600 0.054700 1.46e-01 5.45e-01 1.07e-01
Platelet-calcium-homeostasis 20 4.87e-01 6.59e-01 0.15500 0.070700 1.38e-01 5.84e-01 2.85e-01
Ribosomal-scanning-and-start-codon-recognition 47 6.35e-02 1.94e-01 0.15400 -0.042900 -1.48e-01 6.11e-01 7.90e-02
Extra-nuclear-estrogen-signaling 62 1.56e-01 3.46e-01 0.15400 0.133000 7.83e-02 7.11e-02 2.87e-01
Regulation-of-APC/C-activators-between-G1/S-and-early-anaphase 73 5.38e-02 1.77e-01 0.15400 -0.140000 -6.38e-02 3.86e-02 3.47e-01
Nitric-oxide-stimulates-guanylate-cyclase 15 4.66e-01 6.46e-01 0.15400 0.050800 1.45e-01 7.34e-01 3.31e-01
Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC) 63 2.15e-01 4.14e-01 0.15300 -0.088000 -1.26e-01 2.28e-01 8.47e-02
PI5P,-PP2A-and-IER3-Regulate-PI3K/AKT-Signaling 80 1.32e-01 3.15e-01 0.15300 0.127000 8.56e-02 4.99e-02 1.86e-01
Glutamate-binding,-activation-of-AMPA-receptors-and-synaptic-plasticity 24 5.87e-01 7.27e-01 0.15300 0.092900 1.21e-01 4.31e-01 3.03e-01
Trafficking-of-AMPA-receptors 24 5.87e-01 7.27e-01 0.15300 0.092900 1.21e-01 4.31e-01 3.03e-01
AMER1-mutants-destabilize-the-destruction-complex 14 5.94e-01 7.29e-01 0.15300 0.138000 6.65e-02 3.72e-01 6.67e-01
APC-truncation-mutants-have-impaired-AXIN-binding 14 5.94e-01 7.29e-01 0.15300 0.138000 6.65e-02 3.72e-01 6.67e-01
AXIN-missense-mutants-destabilize-the-destruction-complex 14 5.94e-01 7.29e-01 0.15300 0.138000 6.65e-02 3.72e-01 6.67e-01
AXIN-mutants-destabilize-the-destruction-complex,-activating-WNT-signaling 14 5.94e-01 7.29e-01 0.15300 0.138000 6.65e-02 3.72e-01 6.67e-01
Truncations-of-AMER1-destabilize-the-destruction-complex 14 5.94e-01 7.29e-01 0.15300 0.138000 6.65e-02 3.72e-01 6.67e-01
truncated-APC-mutants-destabilize-the-destruction-complex 14 5.94e-01 7.29e-01 0.15300 0.138000 6.65e-02 3.72e-01 6.67e-01
Interaction-between-L1-and-Ankyrins 22 5.25e-01 6.87e-01 0.15300 -0.131000 -7.82e-02 2.86e-01 5.25e-01
Metabolism-of-nitric-oxide:-eNOS-activation-and-regulation 14 8.36e-02 2.32e-01 0.15300 -0.128000 8.41e-02 4.08e-01 5.86e-01
Lagging-Strand-Synthesis 19 2.60e-01 4.60e-01 0.15300 0.028600 1.50e-01 8.29e-01 2.58e-01
Assembly-of-active-LPL-and-LIPC-lipase-complexes 11 6.37e-01 7.51e-01 0.15200 -0.061100 -1.40e-01 7.26e-01 4.22e-01
Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex 41 4.83e-02 1.62e-01 0.15200 -0.025000 -1.50e-01 7.82e-01 9.71e-02
Interleukin-6-family-signaling 18 7.03e-01 8.03e-01 0.15200 0.101000 1.13e-01 4.60e-01 4.05e-01
Translesion-Synthesis-by-POLH 18 4.21e-01 6.06e-01 0.15200 -0.142000 -5.16e-02 2.95e-01 7.05e-01
HDMs-demethylate-histones 21 3.16e-01 5.19e-01 0.15100 -0.043800 -1.45e-01 7.28e-01 2.51e-01
DDX58/IFIH1-mediated-induction-of-interferon-alpha/beta 58 1.47e-01 3.35e-01 0.15100 0.070300 1.34e-01 3.55e-01 7.81e-02
E3-ubiquitin-ligases-ubiquitinate-target-proteins 42 2.82e-02 1.09e-01 0.15100 -0.013200 -1.50e-01 8.82e-01 9.20e-02
Signaling-by-FGFR2 60 2.56e-01 4.56e-01 0.15100 -0.088500 -1.22e-01 2.36e-01 1.02e-01
Formation-of-HIV-1-elongation-complex-containing-HIV-1-Tat 41 4.51e-01 6.31e-01 0.15000 -0.113000 -9.88e-02 2.09e-01 2.74e-01
HIV-Transcription-Elongation 41 4.51e-01 6.31e-01 0.15000 -0.113000 -9.88e-02 2.09e-01 2.74e-01
Tat-mediated-elongation-of-the-HIV-1-transcript 41 4.51e-01 6.31e-01 0.15000 -0.113000 -9.88e-02 2.09e-01 2.74e-01
NR1H3-&-NR1H2-regulate-gene-expression-linked-to-cholesterol-transport-and-efflux 32 4.19e-01 6.05e-01 0.15000 -0.078900 -1.28e-01 4.40e-01 2.10e-01
Signaling-by-Type-1-Insulin-like-Growth-Factor-1-Receptor-(IGF1R) 39 3.70e-01 5.64e-01 0.15000 0.126000 8.20e-02 1.73e-01 3.76e-01
TP53-Regulates-Transcription-of-Cell-Death-Genes 34 5.30e-01 6.90e-01 0.15000 0.104000 1.08e-01 2.94e-01 2.75e-01
ER-Quality-Control-Compartment-(ERQC) 20 6.90e-01 7.92e-01 0.15000 0.104000 1.07e-01 4.19e-01 4.07e-01
Signaling-by-FGFR3 33 3.17e-01 5.20e-01 0.14900 -0.065700 -1.34e-01 5.14e-01 1.83e-01
Constitutive-Signaling-by-AKT1-E17K-in-Cancer 26 4.77e-01 6.53e-01 0.14900 -0.075500 -1.29e-01 5.05e-01 2.56e-01
Ovarian-tumor-domain-proteases 36 2.22e-01 4.21e-01 0.14900 0.056100 1.38e-01 5.60e-01 1.52e-01
CLEC7A-(Dectin-1)-signaling 92 2.57e-02 1.02e-01 0.14900 -0.137000 -5.85e-02 2.34e-02 3.33e-01
Metalloprotease-DUBs 16 7.08e-01 8.05e-01 0.14900 0.088900 1.19e-01 5.38e-01 4.09e-01
Synthesis-of-PIPs-at-the-Golgi-membrane 15 8.19e-02 2.30e-01 0.14900 0.080200 -1.25e-01 5.91e-01 4.02e-01
Death-Receptor-Signalling 129 8.68e-02 2.36e-01 0.14900 0.097100 1.12e-01 5.71e-02 2.77e-02
Signaling-by-NOTCH2 30 5.66e-01 7.13e-01 0.14800 0.097400 1.12e-01 3.56e-01 2.88e-01
RNA-Polymerase-I-Promoter-Clearance 50 3.92e-01 5.84e-01 0.14800 -0.098600 -1.11e-01 2.28e-01 1.75e-01
RNA-Polymerase-I-Transcription 50 3.92e-01 5.84e-01 0.14800 -0.098600 -1.11e-01 2.28e-01 1.75e-01
Phospholipid-metabolism 179 1.12e-02 5.59e-02 0.14800 -0.079900 -1.25e-01 6.56e-02 4.00e-03
Antigen-activates-B-Cell-Receptor-(BCR)-leading-to-generation-of-second-messengers 29 1.48e-02 6.71e-02 0.14800 -0.051000 1.39e-01 6.34e-01 1.96e-01
LGI-ADAM-interactions 10 3.36e-01 5.35e-01 0.14800 0.013400 -1.47e-01 9.41e-01 4.20e-01
Cap-dependent-Translation-Initiation 86 9.02e-02 2.39e-01 0.14800 -0.074200 -1.28e-01 2.35e-01 4.10e-02
Eukaryotic-Translation-Initiation 86 9.02e-02 2.39e-01 0.14800 -0.074200 -1.28e-01 2.35e-01 4.10e-02
C-type-lectin-receptors-(CLRs) 114 5.20e-02 1.71e-01 0.14800 -0.125000 -7.76e-02 2.08e-02 1.53e-01
RAB-geranylgeranylation 51 1.00e-03 8.01e-03 0.14800 0.142000 -4.10e-02 8.01e-02 6.13e-01
Synthesis-of-Prostaglandins-(PG)-and-Thromboxanes-(TX) 13 1.40e-01 3.27e-01 0.14700 0.059600 -1.35e-01 7.10e-01 4.00e-01
Presynaptic-phase-of-homologous-DNA-pairing-and-strand-exchange 38 1.91e-01 3.89e-01 0.14700 0.052400 1.38e-01 5.76e-01 1.42e-01
Post-translational-modification:-synthesis-of-GPI-anchored-proteins 59 3.26e-01 5.28e-01 0.14700 -0.094700 -1.13e-01 2.09e-01 1.35e-01
Cytosolic-sulfonation-of-small-molecules 12 2.42e-01 4.40e-01 0.14700 0.145000 -2.40e-02 3.85e-01 8.85e-01
Dopamine-Neurotransmitter-Release-Cycle 17 4.02e-01 5.93e-01 0.14600 0.040000 1.41e-01 7.75e-01 3.15e-01
Aquaporin-mediated-transport 34 1.77e-01 3.72e-01 0.14600 -0.042800 -1.40e-01 6.66e-01 1.58e-01
Cohesin-Loading-onto-Chromatin 10 1.86e-01 3.81e-01 0.14600 0.098800 -1.08e-01 5.88e-01 5.55e-01
Amyloid-fiber-formation 38 4.85e-01 6.58e-01 0.14600 0.093100 1.13e-01 3.21e-01 2.29e-01
Nuclear-signaling-by-ERBB4 28 4.87e-01 6.59e-01 0.14600 0.124000 7.65e-02 2.55e-01 4.84e-01
DNA-Replication-Pre-Initiation 80 2.28e-05 3.89e-04 0.14600 -0.139000 4.26e-02 3.15e-02 5.10e-01
Protein-methylation 13 7.45e-01 8.30e-01 0.14500 -0.120000 -8.20e-02 4.54e-01 6.09e-01
Nucleotide-salvage 20 4.20e-01 6.06e-01 0.14500 0.050500 1.36e-01 6.96e-01 2.92e-01
TGF-beta-receptor-signaling-activates-SMADs 32 2.37e-01 4.36e-01 0.14500 0.137000 4.79e-02 1.81e-01 6.39e-01
CD28-co-stimulation 32 4.12e-01 5.99e-01 0.14500 0.071500 1.26e-01 4.84e-01 2.18e-01
Signal-Transduction 1697 3.11e-13 1.81e-11 0.14400 0.113000 8.99e-02 3.26e-14 1.55e-09
Activation-of-APC/C-and-APC/C:Cdc20-mediated-degradation-of-mitotic-proteins 69 4.15e-02 1.48e-01 0.14400 -0.136000 -4.52e-02 5.05e-02 5.16e-01
Influenza-Infection 118 1.15e-01 2.85e-01 0.14300 -0.090800 -1.11e-01 8.89e-02 3.76e-02
Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC) 82 1.48e-01 3.35e-01 0.14300 -0.077700 -1.20e-01 2.24e-01 5.98e-02
Nonsense-Mediated-Decay-(NMD) 82 1.48e-01 3.35e-01 0.14300 -0.077700 -1.20e-01 2.24e-01 5.98e-02
Biosynthesis-of-the-N-glycan-precursor-(dolichol-lipid-linked-oligosaccharide,-LLO)-and-transfer-to-a-nascent-protein 69 6.68e-04 5.77e-03 0.14300 0.142000 -1.72e-02 4.15e-02 8.04e-01
Regulation-of-innate-immune-responses-to-cytosolic-DNA 13 7.82e-01 8.49e-01 0.14300 0.088300 1.12e-01 5.81e-01 4.83e-01
Downregulation-of-ERBB2:ERBB3-signaling 13 7.99e-01 8.59e-01 0.14200 -0.094800 -1.06e-01 5.54e-01 5.07e-01
L13a-mediated-translational-silencing-of-Ceruloplasmin-expression 78 8.15e-02 2.30e-01 0.14200 -0.061500 -1.28e-01 3.48e-01 5.08e-02
Clathrin-mediated-endocytosis 121 1.15e-02 5.70e-02 0.14100 0.131000 5.42e-02 1.32e-02 3.04e-01
Nucleotide-Excision-Repair 109 1.64e-01 3.56e-01 0.14100 -0.103000 -9.68e-02 6.36e-02 8.12e-02
Signaling-by-SCF-KIT 40 5.15e-01 6.78e-01 0.14100 0.103000 9.64e-02 2.60e-01 2.91e-01
Signaling-by-NTRK2-(TRKB) 22 1.82e-01 3.77e-01 0.14100 -0.008870 -1.40e-01 9.43e-01 2.54e-01
Signaling-by-FGFR4 33 2.30e-01 4.27e-01 0.14000 -0.043700 -1.33e-01 6.64e-01 1.85e-01
Interleukin-3,-Interleukin-5-and-GM-CSF-signaling 38 5.35e-01 6.92e-01 0.14000 0.095300 1.03e-01 3.09e-01 2.73e-01
Metabolism-of-folate-and-pterines 16 1.48e-01 3.35e-01 0.14000 0.035500 -1.35e-01 8.06e-01 3.48e-01
Processive-synthesis-on-the-C-strand-of-the-telomere 10 2.41e-01 4.40e-01 0.14000 -0.123000 6.59e-02 5.00e-01 7.18e-01
DNA-Double-Strand-Break-Response 40 4.79e-01 6.53e-01 0.14000 -0.111000 -8.53e-02 2.26e-01 3.51e-01
APC-Cdc20-mediated-degradation-of-Nek2A 23 2.98e-01 5.06e-01 0.14000 0.136000 3.37e-02 2.61e-01 7.80e-01
RNA-polymerase-II-transcribes-snRNA-genes 70 3.09e-01 5.15e-01 0.13900 -0.091300 -1.05e-01 1.87e-01 1.27e-01
Negative-regulation-of-FGFR4-signaling 23 5.80e-01 7.22e-01 0.13900 -0.072500 -1.19e-01 5.48e-01 3.23e-01
Transmission-across-Chemical-Synapses 164 7.22e-02 2.10e-01 0.13900 0.102000 9.53e-02 2.51e-02 3.56e-02
Membrane-binding-and-targetting-of-GAG-proteins 14 6.04e-01 7.34e-01 0.13900 0.128000 5.30e-02 4.05e-01 7.31e-01
Synthesis-And-Processing-Of-GAG,-GAGPOL-Polyproteins 14 6.04e-01 7.34e-01 0.13900 0.128000 5.30e-02 4.05e-01 7.31e-01
Glucagon-signaling-in-metabolic-regulation 24 2.45e-01 4.43e-01 0.13900 0.136000 2.60e-02 2.48e-01 8.26e-01
Cell-cell-junction-organization 33 2.53e-02 1.01e-01 0.13800 0.135000 -2.99e-02 1.80e-01 7.66e-01
Nuclear-import-of-Rev-protein 31 4.03e-01 5.93e-01 0.13800 -0.061500 -1.24e-01 5.54e-01 2.34e-01
Constitutive-Signaling-by-NOTCH1-HD-Domain-Mutants 15 7.88e-01 8.52e-01 0.13800 -0.100000 -9.44e-02 5.00e-01 5.27e-01
Signaling-by-NOTCH1-HD-Domain-Mutants-in-Cancer 15 7.88e-01 8.52e-01 0.13800 -0.100000 -9.44e-02 5.00e-01 5.27e-01
Synthesis-of-PIPs-at-the-early-endosome-membrane 16 7.40e-01 8.26e-01 0.13800 0.111000 8.12e-02 4.42e-01 5.74e-01
Assembly-Of-The-HIV-Virion 15 4.26e-01 6.09e-01 0.13700 0.135000 2.64e-02 3.67e-01 8.59e-01
GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit 80 8.19e-02 2.30e-01 0.13700 -0.057400 -1.24e-01 3.76e-01 5.45e-02
Peptide-ligand-binding-receptors 57 5.45e-03 3.23e-02 0.13700 0.136000 -1.06e-02 7.50e-02 8.90e-01
HDR-through-Homologous-Recombination-(HRR) 63 2.21e-01 4.21e-01 0.13700 0.068800 1.18e-01 3.46e-01 1.05e-01
Transcriptional-regulation-of-white-adipocyte-differentiation 78 1.86e-01 3.81e-01 0.13600 -0.073100 -1.15e-01 2.65e-01 7.87e-02
Signalling-to-RAS 17 7.58e-01 8.35e-01 0.13600 0.104000 8.80e-02 4.57e-01 5.30e-01
Post-NMDA-receptor-activation-events 50 1.31e-03 9.94e-03 0.13600 0.122000 -6.09e-02 1.36e-01 4.56e-01
Alpha-protein-kinase-1-signaling-pathway 11 3.48e-01 5.44e-01 0.13600 0.135000 -1.61e-02 4.37e-01 9.27e-01
RMTs-methylate-histone-arginines 28 3.75e-01 5.67e-01 0.13600 -0.051100 -1.26e-01 6.40e-01 2.49e-01
Fc-epsilon-receptor-(FCERI)-signaling 121 9.77e-02 2.51e-01 0.13600 -0.112000 -7.74e-02 3.44e-02 1.42e-01
Miscellaneous-transport-and-binding-events 20 7.31e-01 8.21e-01 0.13600 -0.090300 -1.01e-01 4.84e-01 4.33e-01
Nef-mediates-down-modulation-of-cell-surface-receptors-by-recruiting-them-to-clathrin-adapters 17 1.90e-01 3.89e-01 0.13500 0.134000 -1.89e-02 3.39e-01 8.93e-01
Regulation-of-TNFR1-signaling 32 4.88e-01 6.60e-01 0.13500 0.070200 1.16e-01 4.92e-01 2.58e-01
Transport-of-inorganic-cations/anions-and-amino-acids/oligopeptides 67 3.61e-01 5.54e-01 0.13500 0.099200 9.12e-02 1.61e-01 1.97e-01
Regulation-of-PLK1-Activity-at-G2/M-Transition 86 5.72e-02 1.83e-01 0.13500 0.124000 5.19e-02 4.67e-02 4.06e-01
HIV-Infection 209 4.52e-02 1.54e-01 0.13500 -0.094100 -9.62e-02 1.92e-02 1.68e-02
Transcriptional-Regulation-by-TP53 334 6.12e-03 3.51e-02 0.13500 -0.101000 -8.84e-02 1.50e-03 5.66e-03
VEGFA-VEGFR2-Pathway 90 2.53e-01 4.52e-01 0.13400 0.088900 1.00e-01 1.45e-01 1.00e-01
Loss-of-Nlp-from-mitotic-centrosomes 68 9.32e-02 2.44e-01 0.13400 0.125000 4.92e-02 7.55e-02 4.84e-01
Loss-of-proteins-required-for-interphase-microtubule-organization-from-the-centrosome 68 9.32e-02 2.44e-01 0.13400 0.125000 4.92e-02 7.55e-02 4.84e-01
Cytosolic-iron-sulfur-cluster-assembly 13 4.92e-01 6.61e-01 0.13300 -0.131000 -2.40e-02 4.15e-01 8.81e-01
Transcription-Coupled-Nucleotide-Excision-Repair-(TC-NER) 77 3.23e-01 5.25e-01 0.13300 -0.097400 -9.01e-02 1.40e-01 1.72e-01
Rab-regulation-of-trafficking 111 1.29e-01 3.10e-01 0.13300 -0.075200 -1.09e-01 1.72e-01 4.73e-02
Transcriptional-regulation-of-pluripotent-stem-cells 15 1.42e-01 3.28e-01 0.13200 0.067300 -1.14e-01 6.52e-01 4.45e-01
Cardiac-conduction 95 1.52e-01 3.39e-01 0.13200 -0.111000 -7.14e-02 6.17e-02 2.29e-01
Activation-of-NMDA-receptors-and-postsynaptic-events 59 1.36e-02 6.36e-02 0.13200 0.132000 3.04e-03 7.97e-02 9.68e-01
eNOS-activation 10 7.04e-01 8.03e-01 0.13200 -0.123000 -4.68e-02 4.99e-01 7.98e-01
Basigin-interactions 19 7.45e-01 8.30e-01 0.13200 0.102000 8.42e-02 4.43e-01 5.26e-01
HDACs-deacetylate-histones 31 1.63e-02 7.18e-02 0.13200 0.107000 -7.60e-02 3.01e-01 4.64e-01
G-beta:gamma-signalling-through-BTK 12 3.51e-01 5.46e-01 0.13100 0.131000 -1.30e-02 4.33e-01 9.38e-01
PI3K-events-in-ERBB2-signaling 15 3.39e-01 5.36e-01 0.13100 0.131000 3.04e-03 3.79e-01 9.84e-01
Signaling-by-ERBB2-in-Cancer 24 3.20e-01 5.22e-01 0.13100 0.127000 3.01e-02 2.80e-01 7.99e-01
G-protein-mediated-events 46 2.59e-01 4.59e-01 0.13100 0.053500 1.19e-01 5.30e-01 1.61e-01
Platelet-sensitization-by-LDL 16 7.72e-01 8.44e-01 0.13100 -0.104000 -7.94e-02 4.73e-01 5.82e-01
ISG15-antiviral-mechanism 67 3.90e-01 5.83e-01 0.13100 -0.092300 -9.24e-02 1.92e-01 1.91e-01
HDR-through-Single-Strand-Annealing-(SSA) 36 1.57e-01 3.47e-01 0.13000 0.025000 1.28e-01 7.95e-01 1.84e-01
TNFR1-induced-NFkappaB-signaling-pathway 25 7.05e-01 8.03e-01 0.13000 0.091300 9.27e-02 4.30e-01 4.23e-01
Ephrin-signaling 19 2.15e-01 4.14e-01 0.13000 0.130000 -7.86e-03 3.27e-01 9.53e-01
Cell-surface-interactions-at-the-vascular-wall 88 2.85e-01 4.91e-01 0.13000 0.086900 9.68e-02 1.59e-01 1.17e-01
Signaling-by-FGFR3-fusions-in-cancer 10 7.34e-01 8.22e-01 0.13000 -0.050000 -1.20e-01 7.84e-01 5.13e-01
Gene-and-protein-expression-by-JAK-STAT-signaling-after-Interleukin-12-stimulation 27 1.16e-01 2.87e-01 0.12900 0.129000 -8.29e-03 2.47e-01 9.41e-01
Interleukin-2-family-signaling 32 6.40e-01 7.51e-01 0.12900 0.095100 8.69e-02 3.52e-01 3.95e-01
Eukaryotic-Translation-Termination 62 3.44e-01 5.39e-01 0.12900 -0.073700 -1.06e-01 3.16e-01 1.51e-01
rRNA-processing 178 9.01e-02 2.39e-01 0.12800 -0.089400 -9.21e-02 3.99e-02 3.44e-02
Thromboxane-signalling-through-TP-receptor 15 3.81e-01 5.73e-01 0.12800 0.128000 8.11e-03 3.91e-01 9.57e-01
Cargo-concentration-in-the-ER 26 7.20e-02 2.10e-01 0.12800 0.123000 -3.47e-02 2.78e-01 7.59e-01
Stimuli-sensing-channels 55 4.47e-01 6.30e-01 0.12800 -0.080400 -9.90e-02 3.02e-01 2.04e-01
RUNX1-interacts-with-co-factors-whose-precise-effect-on-RUNX1-targets-is-not-known 36 1.90e-02 8.07e-02 0.12700 0.118000 -4.79e-02 2.21e-01 6.19e-01
Switching-of-origins-to-a-post-replicative-state 84 1.58e-02 7.03e-02 0.12700 -0.125000 -2.36e-02 4.79e-02 7.09e-01
VxPx-cargo-targeting-to-cilium 18 7.52e-01 8.33e-01 0.12700 0.102000 7.59e-02 4.54e-01 5.77e-01
MAP-kinase-activation 61 1.40e-01 3.27e-01 0.12700 -0.045500 -1.19e-01 5.39e-01 1.09e-01
IKK-complex-recruitment-mediated-by-RIP1 20 3.27e-01 5.29e-01 0.12700 0.126000 1.58e-02 3.31e-01 9.03e-01
NEP/NS2-Interacts-with-the-Cellular-Export-Machinery 30 5.45e-01 6.96e-01 0.12700 -0.064500 -1.09e-01 5.41e-01 3.02e-01
G2/M-DNA-damage-checkpoint 56 1.43e-01 3.31e-01 0.12600 0.041300 1.19e-01 5.93e-01 1.22e-01
CREB1-phosphorylation-through-NMDA-receptor-mediated-activation-of-RAS-signaling 21 9.58e-02 2.48e-01 0.12600 0.115000 -5.26e-02 3.63e-01 6.77e-01
Plasma-lipoprotein-remodeling 19 5.29e-01 6.90e-01 0.12600 -0.118000 -4.23e-02 3.71e-01 7.50e-01
Centrosome-maturation 78 1.17e-01 2.87e-01 0.12600 0.115000 5.08e-02 7.93e-02 4.39e-01
Recruitment-of-mitotic-centrosome-proteins-and-complexes 78 1.17e-01 2.87e-01 0.12600 0.115000 5.08e-02 7.93e-02 4.39e-01
Regulation-of-TP53-Expression-and-Degradation 35 6.24e-01 7.45e-01 0.12500 -0.094300 -8.26e-02 3.34e-01 3.98e-01
Serotonin-Neurotransmitter-Release-Cycle 13 7.33e-01 8.22e-01 0.12500 0.056100 1.12e-01 7.26e-01 4.85e-01
Plasma-lipoprotein-clearance 27 6.85e-01 7.90e-01 0.12500 -0.078900 -9.67e-02 4.78e-01 3.85e-01
Interleukin-1-signaling 90 2.77e-02 1.08e-01 0.12500 -0.120000 -3.26e-02 4.86e-02 5.93e-01
Signaling-by-the-B-Cell-Receptor-(BCR) 103 2.88e-03 1.86e-02 0.12400 -0.124000 -1.17e-02 3.00e-02 8.37e-01
Complement-cascade 26 6.68e-01 7.76e-01 0.12400 -0.072700 -1.01e-01 5.21e-01 3.74e-01
Chromosome-Maintenance 52 5.16e-01 6.78e-01 0.12400 0.085800 8.94e-02 2.85e-01 2.65e-01
Nucleobase-catabolism 29 5.14e-01 6.78e-01 0.12300 -0.110000 -5.55e-02 3.06e-01 6.05e-01
RAB-GEFs-exchange-GTP-for-GDP-on-RABs 81 2.26e-01 4.23e-01 0.12300 -0.064200 -1.05e-01 3.18e-01 1.02e-01
Apoptotic-factor-mediated-response 15 5.86e-01 7.27e-01 0.12300 -0.036200 -1.17e-01 8.08e-01 4.31e-01
Adrenaline,noradrenaline-inhibits-insulin-secretion 21 6.55e-01 7.62e-01 0.12300 0.107000 6.02e-02 3.96e-01 6.33e-01
Transport-of-vitamins,-nucleosides,-and-related-molecules 29 2.86e-01 4.92e-01 0.12300 0.120000 2.63e-02 2.65e-01 8.06e-01
Peptide-chain-elongation 57 3.71e-01 5.64e-01 0.12300 -0.065700 -1.03e-01 3.91e-01 1.77e-01
TICAM1,TRAF6-dependent-induction-of-TAK1-complex 11 3.06e-01 5.12e-01 0.12200 0.054700 -1.10e-01 7.53e-01 5.29e-01
Disassembly-of-the-destruction-complex-and-recruitment-of-AXIN-to-the-membrane 27 8.77e-02 2.37e-01 0.12200 0.119000 -2.99e-02 2.86e-01 7.88e-01
Repression-of-WNT-target-genes 14 8.34e-01 8.84e-01 0.12200 0.092800 7.92e-02 5.48e-01 6.08e-01
Activation-of-BH3-only-proteins 28 5.99e-01 7.34e-01 0.12100 0.104000 6.20e-02 3.41e-01 5.70e-01
RNA-Polymerase-II-Pre-transcription-Events 77 3.75e-01 5.67e-01 0.12100 -0.077900 -9.23e-02 2.38e-01 1.62e-01
Signaling-by-ROBO-receptors 167 1.37e-01 3.22e-01 0.12000 -0.087000 -8.30e-02 5.28e-02 6.48e-02
FOXO-mediated-transcription 54 2.01e-01 3.98e-01 0.12000 -0.041400 -1.13e-01 5.99e-01 1.52e-01
Circadian-Clock 66 8.73e-02 2.37e-01 0.12000 -0.031300 -1.16e-01 6.60e-01 1.04e-01
Downstream-signaling-of-activated-FGFR1 20 1.98e-01 3.95e-01 0.12000 0.022200 -1.18e-01 8.64e-01 3.62e-01
Recruitment-and-ATM-mediated-phosphorylation-of-repair-and-signaling-proteins-at-DNA-double-strand-breaks 39 5.64e-01 7.12e-01 0.12000 -0.097700 -6.91e-02 2.91e-01 4.55e-01
Signaling-by-FGFR-in-disease 53 5.30e-01 6.90e-01 0.12000 -0.088000 -8.10e-02 2.68e-01 3.08e-01
Iron-uptake-and-transport 49 8.15e-02 2.30e-01 0.12000 -0.013100 -1.19e-01 8.74e-01 1.50e-01
Golgi-Associated-Vesicle-Biogenesis 50 3.01e-01 5.09e-01 0.11900 0.109000 4.97e-02 1.84e-01 5.43e-01
Dual-Incision-in-GG-NER 40 5.44e-01 6.96e-01 0.11900 -0.066900 -9.85e-02 4.65e-01 2.81e-01
Deactivation-of-the-beta-catenin-transactivating-complex 39 5.48e-01 6.97e-01 0.11900 -0.066200 -9.88e-02 4.74e-01 2.86e-01
HIV-elongation-arrest-and-recovery 31 2.39e-01 4.37e-01 0.11900 -0.118000 -1.85e-02 2.58e-01 8.59e-01
Pausing-and-recovery-of-HIV-elongation 31 2.39e-01 4.37e-01 0.11900 -0.118000 -1.85e-02 2.58e-01 8.59e-01
Downregulation-of-TGF-beta-receptor-signaling 26 4.18e-01 6.04e-01 0.11900 0.114000 3.49e-02 3.16e-01 7.58e-01
NR1H2-and-NR1H3-mediated-signaling 40 4.78e-01 6.53e-01 0.11900 -0.058900 -1.03e-01 5.19e-01 2.60e-01
XBP1(S)-activates-chaperone-genes 48 2.87e-02 1.11e-01 0.11900 0.117000 -1.57e-02 1.59e-01 8.51e-01
IGF1R-signaling-cascade 38 4.94e-01 6.62e-01 0.11800 0.103000 5.84e-02 2.72e-01 5.34e-01
Cytokine-Signaling-in-Immune-system 610 7.31e-04 6.19e-03 0.11800 0.075700 9.06e-02 1.52e-03 1.46e-04
HDR-through-Homologous-Recombination-(HRR)-or-Single-Strand-Annealing-(SSA) 89 1.27e-01 3.08e-01 0.11800 0.049100 1.07e-01 4.24e-01 8.14e-02
G-alpha-(s)-signalling-events 81 3.96e-01 5.86e-01 0.11800 0.081800 8.46e-02 2.04e-01 1.88e-01
Reproduction 52 4.55e-01 6.34e-01 0.11800 0.097800 6.52e-02 2.23e-01 4.16e-01
Metal-ion-SLC-transporters 20 2.67e-01 4.71e-01 0.11800 0.117000 -7.22e-03 3.64e-01 9.55e-01
Vasopressin-regulates-renal-water-homeostasis-via-Aquaporins 31 1.52e-01 3.39e-01 0.11700 0.001110 -1.17e-01 9.91e-01 2.58e-01
Phase-0---rapid-depolarisation 30 7.05e-01 8.03e-01 0.11700 -0.087400 -7.83e-02 4.08e-01 4.58e-01
APC/C-mediated-degradation-of-cell-cycle-proteins 79 1.31e-01 3.13e-01 0.11700 -0.108000 -4.44e-02 9.58e-02 4.95e-01
Regulation-of-mitotic-cell-cycle 79 1.31e-01 3.13e-01 0.11700 -0.108000 -4.44e-02 9.58e-02 4.95e-01
Activation-of-kainate-receptors-upon-glutamate-binding 22 3.66e-01 5.60e-01 0.11700 0.116000 1.71e-02 3.47e-01 8.90e-01
NOTCH4-Activation-and-Transmission-of-Signal-to-the-Nucleus 10 5.28e-01 6.90e-01 0.11700 0.005500 -1.17e-01 9.76e-01 5.23e-01
Cytosolic-sensors-of-pathogen-associated-DNA 59 1.10e-01 2.74e-01 0.11700 0.027000 1.13e-01 7.20e-01 1.32e-01
TCR-signaling 94 6.13e-02 1.90e-01 0.11700 -0.110000 -3.76e-02 6.49e-02 5.29e-01
Detoxification-of-Reactive-Oxygen-Species 33 6.14e-01 7.38e-01 0.11700 -0.065000 -9.67e-02 5.19e-01 3.36e-01
Transport-to-the-Golgi-and-subsequent-modification 145 2.99e-06 5.79e-05 0.11600 0.110000 -3.79e-02 2.23e-02 4.32e-01
Cellular-responses-to-stress 435 8.10e-03 4.37e-02 0.11600 -0.078600 -8.58e-02 5.16e-03 2.26e-03
Erythropoietin-activates-Phosphoinositide-3-kinase-(PI3K) 11 6.55e-01 7.62e-01 0.11600 0.113000 2.50e-02 5.16e-01 8.86e-01
Antigen-processing:-Ubiquitination-&-Proteasome-degradation 274 4.18e-02 1.48e-01 0.11600 -0.074600 -8.86e-02 3.41e-02 1.19e-02
Other-interleukin-signaling 19 5.82e-01 7.24e-01 0.11600 0.038800 1.09e-01 7.70e-01 4.11e-01
HCMV-Infection 80 2.50e-03 1.65e-02 0.11500 0.113000 -2.17e-02 8.02e-02 7.37e-01
IRE1alpha-activates-chaperones 50 1.69e-02 7.37e-02 0.11500 0.111000 -3.08e-02 1.75e-01 7.06e-01
Acyl-chain-remodelling-of-PS 14 7.03e-01 8.03e-01 0.11500 -0.043300 -1.07e-01 7.79e-01 4.90e-01
Formation-of-the-cornified-envelope 17 2.31e-01 4.30e-01 0.11500 0.109000 -3.72e-02 4.37e-01 7.90e-01
Transcriptional-Regulation-by-VENTX 34 3.07e-01 5.12e-01 0.11500 0.111000 2.90e-02 2.62e-01 7.70e-01
GPCR-ligand-binding 157 4.65e-02 1.57e-01 0.11400 0.102000 5.13e-02 2.81e-02 2.68e-01
Asparagine-N-linked-glycosylation 251 7.80e-09 2.56e-07 0.11400 0.111000 -2.45e-02 2.51e-03 5.05e-01
Retrograde-transport-at-the-Trans-Golgi-Network 46 1.11e-02 5.52e-02 0.11300 0.064400 -9.32e-02 4.50e-01 2.75e-01
Negative-regulators-of-DDX58/IFIH1-signaling 32 3.31e-01 5.31e-01 0.11300 0.027200 1.10e-01 7.90e-01 2.83e-01
Cellular-responses-to-external-stimuli 438 1.01e-02 5.19e-02 0.11300 -0.075100 -8.40e-02 7.30e-03 2.70e-03
Regulation-of-Complement-cascade 22 7.68e-01 8.41e-01 0.11200 -0.068400 -8.92e-02 5.79e-01 4.69e-01
Negative-regulation-of-the-PI3K/AKT-network 87 3.36e-01 5.35e-01 0.11200 0.090800 6.58e-02 1.44e-01 2.89e-01
Inositol-phosphate-metabolism 42 6.09e-01 7.37e-01 0.11200 0.068400 8.87e-02 4.43e-01 3.20e-01
Recruitment-of-NuMA-to-mitotic-centrosomes 78 1.04e-01 2.64e-01 0.11200 0.107000 3.38e-02 1.03e-01 6.06e-01
Immune-System 1477 5.03e-07 1.19e-05 0.11200 0.085000 7.26e-02 7.86e-08 4.51e-06
Butyrate-Response-Factor-1-(BRF1)-binds-and-destabilizes-mRNA 16 7.38e-01 8.24e-01 0.11200 -0.099800 -5.03e-02 4.90e-01 7.28e-01
Regulation-of-TP53-Activity-through-Methylation 17 2.93e-01 5.00e-01 0.11100 -0.109000 2.41e-02 4.38e-01 8.64e-01
Response-of-Mtb-to-phagocytosis 21 6.71e-01 7.78e-01 0.11100 -0.049100 -9.92e-02 6.97e-01 4.31e-01
CTLA4-inhibitory-signaling 19 6.32e-01 7.50e-01 0.11000 -0.103000 -3.96e-02 4.38e-01 7.65e-01
Frs2-mediated-activation 11 5.37e-01 6.93e-01 0.11000 0.110000 -4.75e-03 5.27e-01 9.78e-01
COPII-mediated-vesicle-transport 58 7.93e-03 4.31e-02 0.11000 0.043800 -1.01e-01 5.65e-01 1.85e-01
Myogenesis 22 4.03e-01 5.94e-01 0.10900 0.109000 1.41e-02 3.78e-01 9.09e-01
Misspliced-GSK3beta-mutants-stabilize-beta-catenin 15 6.41e-01 7.51e-01 0.10900 0.105000 2.98e-02 4.82e-01 8.41e-01
S33-mutants-of-beta-catenin-aren't-phosphorylated 15 6.41e-01 7.51e-01 0.10900 0.105000 2.98e-02 4.82e-01 8.41e-01
S37-mutants-of-beta-catenin-aren't-phosphorylated 15 6.41e-01 7.51e-01 0.10900 0.105000 2.98e-02 4.82e-01 8.41e-01
S45-mutants-of-beta-catenin-aren't-phosphorylated 15 6.41e-01 7.51e-01 0.10900 0.105000 2.98e-02 4.82e-01 8.41e-01
T41-mutants-of-beta-catenin-aren't-phosphorylated 15 6.41e-01 7.51e-01 0.10900 0.105000 2.98e-02 4.82e-01 8.41e-01
phosphorylation-site-mutants-of-CTNNB1-are-not-targeted-to-the-proteasome-by-the-destruction-complex 15 6.41e-01 7.51e-01 0.10900 0.105000 2.98e-02 4.82e-01 8.41e-01
Interferon-Signaling 141 9.06e-03 4.77e-02 0.10800 0.023500 1.06e-01 6.31e-01 3.03e-02
Extension-of-Telomeres 28 4.85e-01 6.58e-01 0.10800 0.034600 1.02e-01 7.51e-01 3.48e-01
NoRC-negatively-regulates-rRNA-expression 47 6.18e-01 7.41e-01 0.10800 -0.082800 -6.87e-02 3.27e-01 4.15e-01
Cooperation-of-Prefoldin-and-TriC/CCT--in-actin-and-tubulin-folding 26 9.70e-02 2.50e-01 0.10700 -0.081600 6.93e-02 4.71e-01 5.41e-01
G-alpha-(12/13)-signalling-events 70 3.78e-01 5.71e-01 0.10700 0.055400 9.12e-02 4.23e-01 1.87e-01
Signaling-by-EGFR-in-Cancer 22 4.39e-01 6.25e-01 0.10700 0.105000 1.63e-02 3.92e-01 8.95e-01
PLC-beta-mediated-events 45 3.51e-01 5.46e-01 0.10700 0.037100 1.00e-01 6.67e-01 2.46e-01
Transport-of-small-molecules 492 7.64e-03 4.20e-02 0.10700 -0.067200 -8.26e-02 1.11e-02 1.80e-03
SUMOylation-of-ubiquitinylation-proteins 37 5.02e-01 6.68e-01 0.10600 -0.044900 -9.63e-02 6.37e-01 3.11e-01
Physiological-factors 11 8.00e-01 8.60e-01 0.10600 0.041900 9.76e-02 8.10e-01 5.75e-01
Regulation-of-TP53-Degradation 34 7.13e-01 8.08e-01 0.10600 -0.081500 -6.78e-02 4.11e-01 4.94e-01
Transcription-of-E2F-targets-under-negative-control-by-DREAM-complex 18 6.21e-01 7.44e-01 0.10600 0.101000 3.12e-02 4.58e-01 8.19e-01
SLC-mediated-transmembrane-transport 150 1.18e-01 2.89e-01 0.10600 0.091400 5.33e-02 5.38e-02 2.61e-01
Cytochrome-P450---arranged-by-substrate-type 27 7.31e-01 8.21e-01 0.10600 -0.060700 -8.65e-02 5.85e-01 4.36e-01
ADP-signalling-through-P2Y-purinoceptor-1 17 2.98e-01 5.06e-01 0.10500 0.100000 -3.25e-02 4.74e-01 8.17e-01
SUMOylation-of-chromatin-organization-proteins 55 8.39e-02 2.32e-01 0.10500 -0.003940 -1.05e-01 9.60e-01 1.78e-01
Transferrin-endocytosis-and-recycling 25 6.23e-01 7.45e-01 0.10500 0.095900 4.30e-02 4.07e-01 7.10e-01
Interleukin-17-signaling 63 1.63e-01 3.56e-01 0.10500 -0.026700 -1.02e-01 7.14e-01 1.64e-01
Membrane-Trafficking 530 1.50e-08 4.57e-07 0.10500 0.103000 1.75e-02 5.05e-05 4.93e-01
Gap-filling-DNA-repair-synthesis-and-ligation-in-TC-NER 63 4.77e-01 6.53e-01 0.10500 -0.086600 -5.87e-02 2.35e-01 4.21e-01
Base-Excision-Repair,-AP-Site-Formation 17 8.11e-01 8.65e-01 0.10500 0.057100 8.75e-02 6.83e-01 5.32e-01
ERCC6-(CSB)-and-EHMT2-(G9a)-positively-regulate-rRNA-expression 16 3.05e-01 5.12e-01 0.10400 0.040100 -9.60e-02 7.81e-01 5.06e-01
Endogenous-sterols 17 2.46e-01 4.44e-01 0.10400 0.085700 -5.88e-02 5.41e-01 6.75e-01
Metabolism-of-carbohydrates 237 3.16e-04 3.13e-03 0.10400 0.102000 1.71e-02 6.78e-03 6.50e-01
Interactions-of-Rev-with-host-cellular-proteins 34 6.01e-01 7.34e-01 0.10400 -0.049500 -9.11e-02 6.18e-01 3.58e-01
Formation-of-a-pool-of-free-40S-subunits 70 1.94e-01 3.91e-01 0.10400 -0.033500 -9.80e-02 6.29e-01 1.57e-01
Signaling-by-ERBB2-KD-Mutants 23 3.19e-01 5.22e-01 0.10300 0.103000 -4.67e-03 3.92e-01 9.69e-01
Vpr-mediated-nuclear-import-of-PICs 31 4.43e-01 6.28e-01 0.10300 -0.028600 -9.91e-02 7.83e-01 3.40e-01
TP53-Regulates-Transcription-of-Cell-Cycle-Genes 45 4.92e-01 6.61e-01 0.10300 0.091500 4.69e-02 2.88e-01 5.86e-01
SHC-mediated-cascade:FGFR2 14 5.82e-01 7.24e-01 0.10300 -0.009910 -1.02e-01 9.49e-01 5.08e-01
Neurotransmitter-receptors-and-postsynaptic-signal-transmission 119 9.17e-02 2.42e-01 0.10300 0.095300 3.81e-02 7.30e-02 4.73e-01
Signaling-by-Interleukins 331 5.30e-02 1.74e-01 0.10300 0.077400 6.73e-02 1.59e-02 3.60e-02
PKA-activation 15 7.34e-01 8.22e-01 0.10200 -0.037200 -9.54e-02 8.03e-01 5.23e-01
Vesicle-mediated-transport 560 1.04e-07 2.77e-06 0.10200 0.099800 2.24e-02 5.99e-05 3.68e-01
TCF-dependent-signaling-in-response-to-WNT 151 2.75e-01 4.83e-01 0.10200 -0.070900 -7.32e-02 1.33e-01 1.21e-01
Activation-of-GABAB-receptors 27 7.92e-01 8.55e-01 0.10200 0.070200 7.37e-02 5.28e-01 5.08e-01
GABA-B-receptor-activation 27 7.92e-01 8.55e-01 0.10200 0.070200 7.37e-02 5.28e-01 5.08e-01
Dual-incision-in-TC-NER 64 5.79e-01 7.22e-01 0.10200 -0.073400 -7.02e-02 3.11e-01 3.32e-01
TICAM1,-RIP1-mediated-IKK-complex-recruitment 18 3.15e-01 5.19e-01 0.10100 0.028300 -9.74e-02 8.35e-01 4.75e-01
HCMV-Late-Events 54 2.98e-02 1.14e-01 0.10100 0.096000 -3.10e-02 2.23e-01 6.94e-01
Ub-specific-processing-proteases 151 1.46e-02 6.62e-02 0.10100 -0.098100 -2.31e-02 3.77e-02 6.25e-01
Cargo-recognition-for-clathrin-mediated-endocytosis 85 6.34e-02 1.94e-01 0.10100 0.099400 1.65e-02 1.14e-01 7.93e-01
NS1-Mediated-Effects-on-Host-Pathways 38 4.99e-01 6.65e-01 0.10000 -0.039100 -9.23e-02 6.77e-01 3.25e-01
MET-activates-RAS-signaling 10 5.68e-01 7.15e-01 0.09950 0.097600 -1.95e-02 5.93e-01 9.15e-01
Insertion-of-tail-anchored-proteins-into-the-endoplasmic-reticulum-membrane 19 8.38e-01 8.88e-01 0.09930 0.060800 7.85e-02 6.47e-01 5.53e-01
Initiation-of-Nuclear-Envelope-Reformation 12 4.06e-01 5.94e-01 0.09890 0.080700 -5.72e-02 6.28e-01 7.32e-01
Nuclear-Envelope-Reassembly 12 4.06e-01 5.94e-01 0.09890 0.080700 -5.72e-02 6.28e-01 7.32e-01
RIPK1-mediated-regulated-necrosis 14 4.31e-01 6.15e-01 0.09870 0.095100 -2.65e-02 5.38e-01 8.64e-01
Regulated-Necrosis 14 4.31e-01 6.15e-01 0.09870 0.095100 -2.65e-02 5.38e-01 8.64e-01
Organelle-biogenesis-and-maintenance 264 3.42e-02 1.26e-01 0.09840 -0.048200 -8.58e-02 1.79e-01 1.67e-02
PI3K/AKT-Signaling-in-Cancer 81 4.18e-01 6.04e-01 0.09830 0.082200 5.40e-02 2.01e-01 4.01e-01
Formation-of-RNA-Pol-II-elongation-complex 56 6.12e-01 7.38e-01 0.09830 -0.076700 -6.16e-02 3.21e-01 4.25e-01
RNA-Polymerase-II-Transcription-Elongation 56 6.12e-01 7.38e-01 0.09830 -0.076700 -6.16e-02 3.21e-01 4.25e-01
Plasma-lipoprotein-assembly,-remodeling,-and-clearance 52 2.93e-01 5.00e-01 0.09800 -0.027400 -9.41e-02 7.33e-01 2.41e-01
GABA-receptor-activation 32 7.72e-01 8.44e-01 0.09790 0.072600 6.57e-02 4.77e-01 5.21e-01
SRP-dependent-cotranslational-protein-targeting-to-membrane 80 5.43e-02 1.77e-01 0.09780 -0.007340 -9.75e-02 9.10e-01 1.32e-01
Signaling-by-VEGF 98 4.46e-01 6.30e-01 0.09750 0.063300 7.41e-02 2.79e-01 2.05e-01
Cyclin-D-associated-events-in-G1 43 2.22e-01 4.21e-01 0.09720 0.096800 8.87e-03 2.73e-01 9.20e-01
G1-Phase 43 2.22e-01 4.21e-01 0.09720 0.096800 8.87e-03 2.73e-01 9.20e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-2-Promoter 25 8.09e-01 8.65e-01 0.09690 -0.075300 -6.09e-02 5.15e-01 5.98e-01
Cell-Cycle-Checkpoints 233 2.67e-02 1.05e-01 0.09680 0.040300 8.80e-02 2.90e-01 2.09e-02
Defective-TPR-may-confer-susceptibility-towards-thyroid-papillary-carcinoma-(TPC) 30 5.05e-01 6.69e-01 0.09680 -0.027500 -9.28e-02 7.95e-01 3.79e-01
Regulation-of-Glucokinase-by-Glucokinase-Regulatory-Protein 30 5.05e-01 6.69e-01 0.09680 -0.027500 -9.28e-02 7.95e-01 3.79e-01
Beta-catenin-phosphorylation-cascade 17 3.41e-01 5.38e-01 0.09640 0.089300 -3.63e-02 5.24e-01 7.96e-01
Signaling-by-GPCR 418 4.36e-02 1.52e-01 0.09580 0.065000 7.04e-02 2.32e-02 1.40e-02
IRS-related-events-triggered-by-IGF1R 37 6.06e-01 7.35e-01 0.09580 0.085100 4.40e-02 3.71e-01 6.43e-01
Signaling-by-NTRKs 91 2.16e-02 8.99e-02 0.09560 0.095600 -3.74e-03 1.15e-01 9.51e-01
Ras-activation-upon-Ca2+-influx-through-NMDA-receptor 14 4.40e-01 6.25e-01 0.09560 0.091000 -2.94e-02 5.56e-01 8.49e-01
RUNX1-regulates-genes-involved-in-megakaryocyte-differentiation-and-platelet-function 34 2.36e-01 4.35e-01 0.09540 -0.095300 4.40e-03 3.37e-01 9.65e-01
G2/M-Checkpoints 125 1.43e-04 1.68e-03 0.09520 -0.065300 6.92e-02 2.08e-01 1.82e-01
MASTL-Facilitates-Mitotic-Progression 10 8.08e-01 8.65e-01 0.09510 0.090800 2.82e-02 6.19e-01 8.77e-01
Signaling-by-NTRK1-(TRKA) 73 4.63e-02 1.57e-01 0.09450 0.094300 -5.17e-03 1.64e-01 9.39e-01
Processing-of-DNA-double-strand-break-ends 58 2.25e-01 4.23e-01 0.09430 0.019900 9.22e-02 7.93e-01 2.25e-01
Export-of-Viral-Ribonucleoproteins-from-Nucleus 31 6.89e-01 7.92e-01 0.09400 -0.045600 -8.22e-02 6.60e-01 4.28e-01
Signaling-by-Hedgehog 122 2.53e-01 4.52e-01 0.09390 0.047200 8.11e-02 3.68e-01 1.22e-01
Translesion-synthesis-by-Y-family-DNA-polymerases-bypasses-lesions-on-DNA-template 37 1.93e-01 3.90e-01 0.09380 -0.009450 9.33e-02 9.21e-01 3.26e-01
RET-signaling 36 4.64e-01 6.44e-01 0.09370 0.089800 2.67e-02 3.51e-01 7.82e-01
Metabolism-of-steroids 104 1.57e-01 3.47e-01 0.09290 -0.031900 -8.72e-02 5.74e-01 1.25e-01
VEGFR2-mediated-cell-proliferation 19 8.26e-01 8.78e-01 0.09240 0.049200 7.82e-02 7.11e-01 5.55e-01
SUMOylation-of-RNA-binding-proteins 46 1.48e-01 3.35e-01 0.09230 0.007130 -9.20e-02 9.33e-01 2.81e-01
PKA-mediated-phosphorylation-of-CREB 17 7.57e-01 8.35e-01 0.09210 -0.034100 -8.56e-02 8.08e-01 5.41e-01
Gamma-carboxylation,-hypusine-formation-and-arylsulfatase-activation 27 7.67e-01 8.41e-01 0.09190 0.077600 4.93e-02 4.85e-01 6.57e-01
Uptake-and-function-of-anthrax-toxins 10 8.41e-01 8.89e-01 0.09150 -0.031700 -8.58e-02 8.62e-01 6.38e-01
Oxidative-Stress-Induced-Senescence 62 1.81e-01 3.75e-01 0.09150 -0.013800 -9.04e-02 8.51e-01 2.18e-01
TBC/RABGAPs 42 2.15e-01 4.14e-01 0.09140 0.000542 -9.14e-02 9.95e-01 3.06e-01
Innate-Immune-System 746 7.02e-03 3.91e-02 0.09130 0.067000 6.21e-02 2.01e-03 4.21e-03
PRC2-methylates-histones-and-DNA 13 6.03e-01 7.34e-01 0.09110 0.004290 -9.10e-02 9.79e-01 5.70e-01
NRIF-signals-cell-death-from-the-nucleus 16 8.26e-01 8.78e-01 0.09110 0.080500 4.26e-02 5.77e-01 7.68e-01
Inhibition-of-replication-initiation-of-damaged-DNA-by-RB1/E2F1 13 9.08e-01 9.35e-01 0.09090 0.057500 7.04e-02 7.20e-01 6.60e-01
Platelet-homeostasis 64 6.47e-01 7.56e-01 0.09080 0.064200 6.42e-02 3.75e-01 3.75e-01
Termination-of-translesion-DNA-synthesis 31 1.79e-01 3.72e-01 0.09070 -0.033300 8.44e-02 7.49e-01 4.16e-01
SHC-mediated-cascade:FGFR1 11 4.92e-01 6.61e-01 0.09050 0.062800 -6.52e-02 7.18e-01 7.08e-01
Adherens-junctions-interactions 20 2.78e-01 4.84e-01 0.09050 0.058500 -6.90e-02 6.51e-01 5.93e-01
IRAK2-mediated-activation-of-TAK1-complex 10 7.06e-01 8.03e-01 0.08960 -0.000215 -8.96e-02 9.99e-01 6.24e-01
PERK-regulates-gene-expression 29 6.25e-01 7.46e-01 0.08960 -0.083800 -3.17e-02 4.35e-01 7.68e-01
Cell-Cycle,-Mitotic 436 5.69e-02 1.83e-01 0.08960 0.066200 6.03e-02 1.83e-02 3.16e-02
Metabolic-disorders-of-biological-oxidation-enzymes 17 3.51e-01 5.46e-01 0.08950 -0.051800 7.30e-02 7.12e-01 6.02e-01
Translesion-synthesis-by-REV1 16 6.40e-01 7.51e-01 0.08940 -0.088700 -1.10e-02 5.39e-01 9.40e-01
Signaling-by-Nuclear-Receptors 200 5.01e-02 1.67e-01 0.08940 -0.033600 -8.28e-02 4.14e-01 4.39e-02
Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency 70 6.31e-01 7.50e-01 0.08920 -0.064000 -6.21e-02 3.55e-01 3.69e-01
Hedgehog-'on'-state 77 1.07e-02 5.42e-02 0.08920 -0.045400 7.67e-02 4.91e-01 2.45e-01
Negative-regulation-of-FGFR2-signaling 25 6.30e-01 7.49e-01 0.08890 -0.026600 -8.49e-02 8.18e-01 4.63e-01
Signaling-by-ERBB4 48 3.13e-01 5.18e-01 0.08830 0.086900 1.58e-02 2.98e-01 8.50e-01
RHO-GTPases-activate-IQGAPs 10 8.93e-01 9.25e-01 0.08810 0.078100 4.07e-02 6.69e-01 8.24e-01
DCC-mediated-attractive-signaling 13 7.48e-01 8.30e-01 0.08810 -0.086100 -1.88e-02 5.91e-01 9.07e-01
MAP3K8-(TPL2)-dependent-MAPK1/3-activation 16 8.48e-01 8.96e-01 0.08790 0.076500 4.32e-02 5.96e-01 7.65e-01
Prolonged-ERK-activation-events 13 5.32e-01 6.90e-01 0.08770 0.083900 -2.56e-02 6.01e-01 8.73e-01
Transport-of-bile-salts-and-organic-acids,-metal-ions-and-amine-compounds 46 6.45e-01 7.54e-01 0.08740 0.075000 4.48e-02 3.79e-01 5.99e-01
Rev-mediated-nuclear-export-of-HIV-RNA 33 7.05e-01 8.03e-01 0.08720 -0.041600 -7.66e-02 6.79e-01 4.47e-01
Early-Phase-of-HIV-Life-Cycle 11 8.53e-01 8.98e-01 0.08700 -0.080700 -3.26e-02 6.43e-01 8.51e-01
Regulation-of-gene-expression-by-Hypoxia-inducible-Factor 10 7.99e-01 8.59e-01 0.08700 -0.017300 -8.52e-02 9.24e-01 6.41e-01
Chromatin-modifying-enzymes 194 1.00e-02 5.17e-02 0.08700 -0.014700 -8.57e-02 7.24e-01 4.00e-02
Chromatin-organization 194 1.00e-02 5.17e-02 0.08700 -0.014700 -8.57e-02 7.24e-01 4.00e-02
Generation-of-second-messenger-molecules 16 7.34e-01 8.22e-01 0.08690 0.083900 2.29e-02 5.62e-01 8.74e-01
TNFR2-non-canonical-NF-kB-pathway 76 1.34e-02 6.31e-02 0.08670 -0.072700 4.73e-02 2.74e-01 4.77e-01
Antiviral-mechanism-by-IFN-stimulated-genes 74 5.09e-01 6.73e-01 0.08650 -0.073900 -4.49e-02 2.72e-01 5.05e-01
Cell-Cycle 519 4.15e-02 1.48e-01 0.08630 0.064500 5.73e-02 1.24e-02 2.64e-02
mRNA-decay-by-3'-to-5'-exoribonuclease 15 6.39e-01 7.51e-01 0.08610 -0.086000 -3.96e-03 5.64e-01 9.79e-01
Signaling-by-WNT-in-cancer 28 2.03e-01 4.02e-01 0.08560 0.067400 -5.28e-02 5.37e-01 6.29e-01
Cholesterol-biosynthesis 23 8.60e-01 9.01e-01 0.08560 -0.054300 -6.61e-02 6.52e-01 5.83e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-1-Promoter 26 8.52e-01 8.98e-01 0.08520 -0.063400 -5.69e-02 5.76e-01 6.16e-01
Pausing-and-recovery-of-Tat-mediated-HIV-elongation 29 3.82e-01 5.73e-01 0.08470 -0.084600 3.43e-03 4.30e-01 9.74e-01
Tat-mediated-HIV-elongation-arrest-and-recovery 29 3.82e-01 5.73e-01 0.08470 -0.084600 3.43e-03 4.30e-01 9.74e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-G2-Cell-Cycle-Arrest 17 9.01e-01 9.31e-01 0.08440 0.063700 5.53e-02 6.49e-01 6.93e-01
Synthesis-of-Leukotrienes-(LT)-and-Eoxins-(EX) 12 6.14e-01 7.38e-01 0.08440 0.016500 -8.27e-02 9.21e-01 6.20e-01
Antigen-processing-Cross-presentation 85 1.88e-02 8.03e-02 0.08430 -0.079300 2.87e-02 2.07e-01 6.48e-01
DNA-Damage/Telomere-Stress-Induced-Senescence 25 8.55e-01 8.99e-01 0.08430 0.064700 5.41e-02 5.76e-01 6.40e-01
RHO-GTPases-Activate-NADPH-Oxidases 19 3.51e-01 5.46e-01 0.08420 0.051800 -6.64e-02 6.96e-01 6.16e-01
Estrogen-dependent-nuclear-events-downstream-of-ESR-membrane-signaling 22 8.10e-01 8.65e-01 0.08390 0.073300 4.07e-02 5.52e-01 7.41e-01
Ion-transport-by-P-type-ATPases 38 3.14e-01 5.19e-01 0.08360 -0.000184 8.36e-02 9.98e-01 3.73e-01
Calnexin/calreticulin-cycle 25 7.64e-01 8.40e-01 0.08230 0.074100 3.58e-02 5.21e-01 7.56e-01
COPI-mediated-anterograde-transport 74 4.93e-02 1.65e-01 0.08200 0.079300 -2.08e-02 2.39e-01 7.58e-01
rRNA-modification-in-the-nucleus-and-cytosol 54 3.51e-01 5.46e-01 0.08170 0.017200 7.99e-02 8.28e-01 3.10e-01
The-role-of-Nef-in-HIV-1-replication-and-disease-pathogenesis 24 5.07e-01 6.71e-01 0.08170 0.081700 1.32e-03 4.88e-01 9.91e-01
Protein-folding 84 5.32e-01 6.90e-01 0.08150 0.044300 6.84e-02 4.83e-01 2.79e-01
PCP/CE-pathway 87 4.76e-01 6.53e-01 0.08120 -0.070300 -4.05e-02 2.57e-01 5.14e-01
E2F-mediated-regulation-of-DNA-replication 22 8.21e-01 8.73e-01 0.08090 0.039100 7.09e-02 7.51e-01 5.65e-01
NOTCH3-Activation-and-Transmission-of-Signal-to-the-Nucleus 25 5.21e-01 6.84e-01 0.08090 -0.004150 -8.08e-02 9.71e-01 4.85e-01
NF-kB-activation-through-FADD/RIP-1-pathway-mediated-by-caspase-8-and--10 10 5.98e-01 7.33e-01 0.08080 -0.056000 5.83e-02 7.59e-01 7.50e-01
ER-to-Golgi-Anterograde-Transport 120 2.34e-03 1.60e-02 0.08030 0.055100 -5.85e-02 2.98e-01 2.69e-01
Late-Phase-of-HIV-Life-Cycle 127 1.64e-01 3.56e-01 0.08010 -0.025400 -7.60e-02 6.22e-01 1.40e-01
B-WICH-complex-positively-regulates-rRNA-expression 32 2.14e-01 4.14e-01 0.08010 -0.067900 4.25e-02 5.07e-01 6.78e-01
Homology-Directed-Repair 95 3.04e-01 5.11e-01 0.08000 0.029100 7.46e-02 6.24e-01 2.10e-01
Neutrophil-degranulation 356 9.72e-02 2.50e-01 0.07990 0.065600 4.56e-02 3.41e-02 1.41e-01
NOTCH3-Intracellular-Domain-Regulates-Transcription 22 4.36e-01 6.22e-01 0.07990 0.077800 -1.82e-02 5.28e-01 8.82e-01
MyD88-cascade-initiated-on-plasma-membrane 77 2.92e-01 4.99e-01 0.07950 -0.021200 -7.66e-02 7.48e-01 2.45e-01
Toll-Like-Receptor-10-(TLR10)-Cascade 77 2.92e-01 4.99e-01 0.07950 -0.021200 -7.66e-02 7.48e-01 2.45e-01
Toll-Like-Receptor-5-(TLR5)-Cascade 77 2.92e-01 4.99e-01 0.07950 -0.021200 -7.66e-02 7.48e-01 2.45e-01
Antigen-Presentation:-Folding,-assembly-and-peptide-loading-of-class-I-MHC 16 8.60e-01 9.01e-01 0.07950 -0.036200 -7.08e-02 8.02e-01 6.24e-01
Regulation-of-IFNG-signaling 13 9.30e-01 9.51e-01 0.07930 -0.051000 -6.08e-02 7.50e-01 7.04e-01
G-alpha-(z)-signalling-events 37 6.88e-01 7.91e-01 0.07910 0.034000 7.14e-02 7.21e-01 4.52e-01
Interleukin-7-signaling 20 6.77e-01 7.82e-01 0.07900 -0.014000 -7.78e-02 9.14e-01 5.47e-01
Binding-and-Uptake-of-Ligands-by-Scavenger-Receptors 32 3.42e-01 5.38e-01 0.07860 -0.012200 7.77e-02 9.05e-01 4.47e-01
HIV-Life-Cycle 138 2.06e-01 4.06e-01 0.07850 -0.029900 -7.26e-02 5.45e-01 1.41e-01
Signaling-by-FGFR1-in-disease 32 4.52e-01 6.32e-01 0.07800 -0.002970 -7.79e-02 9.77e-01 4.46e-01
Transcriptional-regulation-by-RUNX1 158 1.32e-01 3.15e-01 0.07770 -0.073300 -2.59e-02 1.12e-01 5.75e-01
Axon-guidance 432 8.63e-02 2.35e-01 0.07670 0.061900 4.54e-02 2.82e-02 1.08e-01
Synthesis-of-IP3-and-IP4-in-the-cytosol 22 4.38e-01 6.24e-01 0.07650 -0.023400 7.28e-02 8.49e-01 5.54e-01
Nonhomologous-End-Joining-(NHEJ) 32 6.51e-01 7.59e-01 0.07600 -0.072500 -2.29e-02 4.78e-01 8.23e-01
DNA-Damage-Bypass 46 3.39e-01 5.36e-01 0.07530 0.002080 7.53e-02 9.81e-01 3.77e-01
Arachidonic-acid-metabolism 36 3.28e-01 5.29e-01 0.07520 0.074200 -1.22e-02 4.41e-01 8.99e-01
Synthesis-of-DNA 112 1.44e-02 6.58e-02 0.07510 -0.070000 2.74e-02 2.01e-01 6.17e-01
Notch-HLH-transcription-pathway 27 3.56e-01 5.49e-01 0.07480 0.069200 -2.85e-02 5.34e-01 7.98e-01
GPCR-downstream-signalling 380 9.94e-02 2.54e-01 0.07430 0.040500 6.22e-02 1.77e-01 3.80e-02
TAK1-activates-NFkB-by-phosphorylation-and-activation-of-IKKs-complex 24 6.03e-01 7.34e-01 0.07410 0.005390 7.39e-02 9.64e-01 5.31e-01
Cooperation-of-PDCL-(PhLP1)-and-TRiC/CCT-in-G-protein-beta-folding 31 8.61e-01 9.01e-01 0.07370 0.047000 5.68e-02 6.50e-01 5.85e-01
Interleukin-2-signaling 10 7.25e-01 8.16e-01 0.07350 0.017400 -7.14e-02 9.24e-01 6.96e-01
Class-A/1-(Rhodopsin-like-receptors) 108 2.46e-01 4.44e-01 0.07330 0.070300 2.09e-02 2.08e-01 7.08e-01
HSP90-chaperone-cycle-for-steroid-hormone-receptors-(SHR) 31 4.92e-01 6.61e-01 0.07240 -0.072400 7.82e-05 4.85e-01 9.99e-01
Presynaptic-function-of-Kainate-receptors 15 7.09e-01 8.05e-01 0.07240 0.072400 -1.79e-04 6.27e-01 9.99e-01
PCNA-Dependent-Long-Patch-Base-Excision-Repair 20 5.92e-01 7.29e-01 0.07240 -0.006680 7.21e-02 9.59e-01 5.77e-01
G-alpha-(i)-signalling-events 192 2.74e-01 4.81e-01 0.07230 0.036000 6.27e-02 3.90e-01 1.35e-01
Toll-like-Receptor-Cascades 133 3.31e-01 5.31e-01 0.07170 0.064800 3.06e-02 1.97e-01 5.43e-01
Negative-epigenetic-regulation-of-rRNA-expression 50 7.57e-01 8.35e-01 0.07160 -0.059400 -4.00e-02 4.68e-01 6.25e-01
Other-semaphorin-interactions 19 4.90e-01 6.61e-01 0.07150 0.034700 -6.26e-02 7.94e-01 6.37e-01
RNA-Polymerase-III-Chain-Elongation 16 9.13e-01 9.39e-01 0.07140 -0.059600 -3.93e-02 6.80e-01 7.85e-01
Fatty-acyl-CoA-biosynthesis 28 8.78e-01 9.16e-01 0.07120 -0.044500 -5.56e-02 6.84e-01 6.11e-01
Host-Interactions-with-Influenza-Factors 39 5.59e-01 7.09e-01 0.07090 -0.014200 -6.95e-02 8.78e-01 4.53e-01
Translesion-synthesis-by-POLK 17 5.71e-01 7.17e-01 0.07070 -0.066500 2.40e-02 6.35e-01 8.64e-01
Prefoldin-mediated-transfer-of-substrate--to-CCT/TriC 24 3.95e-01 5.86e-01 0.07040 -0.044600 5.45e-02 7.06e-01 6.44e-01
Unfolded-Protein-Response-(UPR) 86 1.36e-01 3.21e-01 0.07010 0.070000 -3.89e-03 2.63e-01 9.50e-01
RNA-Polymerase-II-Transcription 957 2.44e-03 1.64e-02 0.06990 -0.033700 -6.12e-02 8.07e-02 1.51e-03
Activation-of-G-protein-gated-Potassium-channels 15 8.92e-01 9.25e-01 0.06980 -0.030700 -6.27e-02 8.37e-01 6.74e-01
G-protein-gated-Potassium-channels 15 8.92e-01 9.25e-01 0.06980 -0.030700 -6.27e-02 8.37e-01 6.74e-01
Inhibition--of-voltage-gated-Ca2+-channels-via-Gbeta/gamma-subunits 15 8.92e-01 9.25e-01 0.06980 -0.030700 -6.27e-02 8.37e-01 6.74e-01
Glutathione-synthesis-and-recycling 10 8.53e-01 8.98e-01 0.06980 0.010900 6.89e-02 9.52e-01 7.06e-01
Nuclear-Envelope-Breakdown 51 3.04e-01 5.11e-01 0.06970 0.069600 -4.56e-03 3.90e-01 9.55e-01
ATF4-activates-genes-in-response-to-endoplasmic-reticulum--stress 24 4.03e-01 5.93e-01 0.06970 -0.053900 4.42e-02 6.48e-01 7.08e-01
Class-I-MHC-mediated-antigen-processing-&-presentation 323 2.18e-01 4.18e-01 0.06950 -0.040900 -5.62e-02 2.08e-01 8.37e-02
Telomere-Maintenance 34 6.06e-01 7.35e-01 0.06940 0.012900 6.82e-02 8.96e-01 4.92e-01
Processing-and-activation-of-SUMO 10 8.40e-01 8.89e-01 0.06910 0.068700 6.97e-03 7.07e-01 9.70e-01
KSRP-(KHSRP)-binds-and-destabilizes-mRNA 16 7.68e-01 8.41e-01 0.06860 -0.068100 -8.34e-03 6.37e-01 9.54e-01
Purine-salvage 11 8.98e-01 9.29e-01 0.06860 -0.023600 -6.44e-02 8.92e-01 7.12e-01
DNA-Replication 119 1.33e-02 6.29e-02 0.06840 -0.052900 4.34e-02 3.20e-01 4.14e-01
ERKs-are-inactivated 12 8.90e-01 9.25e-01 0.06800 -0.023100 -6.40e-02 8.90e-01 7.01e-01
G-beta:gamma-signalling-through-PI3Kgamma 19 5.12e-01 6.76e-01 0.06790 0.056100 -3.83e-02 6.72e-01 7.73e-01
MAPK6/MAPK4-signaling 81 2.79e-01 4.84e-01 0.06790 -0.067300 -8.93e-03 2.95e-01 8.90e-01
NOTCH4-Intracellular-Domain-Regulates-Transcription 18 9.32e-01 9.52e-01 0.06750 0.044500 5.08e-02 7.44e-01 7.09e-01
Regulation-of-TP53-Activity-through-Phosphorylation 88 1.95e-01 3.91e-01 0.06740 0.002260 6.74e-02 9.71e-01 2.75e-01
FCERI-mediated-Ca+2-mobilization 26 9.05e-01 9.34e-01 0.06720 0.044800 5.00e-02 6.92e-01 6.59e-01
HCMV-Early-Events 57 1.34e-01 3.17e-01 0.06700 0.047200 -4.76e-02 5.38e-01 5.35e-01
Negative-regulation-of-MAPK-pathway 38 8.69e-01 9.08e-01 0.06700 -0.047500 -4.72e-02 6.12e-01 6.15e-01
Signaling-by-FGFR1 38 3.43e-01 5.38e-01 0.06670 0.063800 -1.97e-02 4.97e-01 8.34e-01
G1/S-Transition 126 1.72e-02 7.47e-02 0.06660 -0.058500 3.19e-02 2.57e-01 5.37e-01
Infectious-disease 362 9.88e-02 2.53e-01 0.06640 -0.030400 -5.91e-02 3.22e-01 5.46e-02
Signaling-by-FGFR 67 7.19e-01 8.13e-01 0.06620 -0.036200 -5.55e-02 6.09e-01 4.33e-01
Signaling-by-cytosolic-FGFR1-fusion-mutants 18 5.37e-01 6.93e-01 0.06620 -0.045700 4.80e-02 7.37e-01 7.25e-01
Plasma-lipoprotein-assembly 14 6.40e-01 7.51e-01 0.06610 0.031200 -5.83e-02 8.40e-01 7.06e-01
SUMOylation-of-transcription-factors 15 6.24e-01 7.45e-01 0.06610 0.030000 -5.89e-02 8.41e-01 6.93e-01
TNF-signaling 42 8.07e-01 8.65e-01 0.06610 0.055900 3.52e-02 5.31e-01 6.93e-01
PIP3-activates-AKT-signaling 237 3.56e-01 5.49e-01 0.06600 -0.038400 -5.36e-02 3.10e-01 1.56e-01
Chaperone-Mediated-Autophagy 14 9.06e-01 9.34e-01 0.06580 -0.059500 -2.81e-02 7.00e-01 8.56e-01
MAPK-family-signaling-cascades 242 4.05e-01 5.94e-01 0.06560 0.042100 5.02e-02 2.61e-01 1.79e-01
Gene-expression-(Transcription) 1076 2.07e-03 1.45e-02 0.06540 -0.030400 -5.78e-02 9.59e-02 1.55e-03
Gap-filling-DNA-repair-synthesis-and-ligation-in-GG-NER 24 4.59e-01 6.38e-01 0.06460 -0.039900 5.08e-02 7.35e-01 6.67e-01
Regulation-of-necroptotic-cell-death 12 7.54e-01 8.34e-01 0.06460 0.012000 -6.34e-02 9.43e-01 7.04e-01
Tristetraprolin-(TTP,-ZFP36)-binds-and-destabilizes-mRNA 16 6.73e-01 7.78e-01 0.06450 -0.062600 1.52e-02 6.65e-01 9.16e-01
Negative-regulation-of-FGFR1-signaling 22 6.24e-01 7.45e-01 0.06440 0.007490 -6.40e-02 9.52e-01 6.03e-01
Interleukin-1-family-signaling 114 8.79e-02 2.37e-01 0.06430 -0.063800 7.72e-03 2.40e-01 8.87e-01
Regulation-of-beta-cell-development 19 9.25e-01 9.47e-01 0.06420 0.051900 3.78e-02 6.95e-01 7.75e-01
TP53-regulates-transcription-of-additional-cell-cycle-genes-whose-exact-role-in-the-p53-pathway-remain-uncertain 18 8.28e-01 8.79e-01 0.06390 -0.016700 -6.16e-02 9.02e-01 6.51e-01
CD28-dependent-PI3K/Akt-signaling 21 5.34e-01 6.91e-01 0.06350 -0.031900 5.50e-02 8.00e-01 6.63e-01
Mitotic-Prophase 80 1.05e-01 2.65e-01 0.06340 0.026600 -5.76e-02 6.82e-01 3.73e-01
Fanconi-Anemia-Pathway 34 5.53e-01 7.03e-01 0.06320 -0.063200 1.27e-04 5.24e-01 9.99e-01
Phase-2---plateau-phase 16 6.26e-01 7.46e-01 0.06300 -0.031200 5.47e-02 8.29e-01 7.05e-01
Regulation-of-TP53-Activity-through-Acetylation 28 8.61e-01 9.01e-01 0.06290 -0.030600 -5.49e-02 7.79e-01 6.15e-01
SUMOylation-of-DNA-damage-response-and-repair-proteins 73 5.39e-01 6.93e-01 0.06270 -0.020700 -5.92e-02 7.60e-01 3.82e-01
Post-translational-protein-modification 1122 8.61e-07 1.93e-05 0.06270 0.062100 8.38e-03 5.27e-04 6.40e-01
Intracellular-signaling-by-second-messengers 272 3.81e-01 5.73e-01 0.06260 -0.038900 -4.91e-02 2.71e-01 1.65e-01
Deubiquitination 220 8.02e-03 4.35e-02 0.06250 -0.061300 1.21e-02 1.18e-01 7.58e-01
Cellular-Senescence 118 3.67e-02 1.34e-01 0.06250 0.055400 -2.87e-02 2.99e-01 5.90e-01
Metabolism-of-proteins 1577 1.20e-07 3.14e-06 0.06240 -0.013100 -6.10e-02 3.93e-01 7.33e-05
Meiosis 45 4.69e-01 6.48e-01 0.06220 0.062200 -5.39e-05 4.71e-01 1.00e+00
AKT-phosphorylates-targets-in-the-cytosol 14 8.71e-01 9.09e-01 0.06140 -0.015700 -5.94e-02 9.19e-01 7.01e-01
Nuclear-Pore-Complex-(NPC)-Disassembly 35 3.57e-01 5.51e-01 0.06140 0.047300 -3.92e-02 6.29e-01 6.88e-01
Nicotinamide-salvaging 16 6.69e-01 7.77e-01 0.06130 -0.021700 5.73e-02 8.80e-01 6.92e-01
Cleavage-of-the-damaged-pyrimidine 15 9.49e-01 9.65e-01 0.06110 0.037500 4.82e-02 8.01e-01 7.47e-01
Depyrimidination 15 9.49e-01 9.65e-01 0.06110 0.037500 4.82e-02 8.01e-01 7.47e-01
Recognition-and-association-of-DNA-glycosylase-with-site-containing-an-affected-pyrimidine 15 9.49e-01 9.65e-01 0.06110 0.037500 4.82e-02 8.01e-01 7.47e-01
FCERI-mediated-MAPK-activation 29 4.65e-01 6.45e-01 0.06000 0.029000 -5.25e-02 7.87e-01 6.25e-01
Transcriptional-regulation-by-RUNX2 109 1.04e-01 2.64e-01 0.05970 -0.013000 5.83e-02 8.15e-01 2.94e-01
DAG-and-IP3-signaling 36 8.10e-01 8.65e-01 0.05910 -0.053700 -2.47e-02 5.77e-01 7.98e-01
Chaperonin-mediated-protein-folding 78 4.52e-01 6.32e-01 0.05900 0.012100 5.78e-02 8.53e-01 3.78e-01
Mitotic-G1-phase-and-G1/S-transition 143 3.90e-02 1.41e-01 0.05890 -0.019900 5.55e-02 6.82e-01 2.53e-01
tRNA-modification-in-the-nucleus-and-cytosol 41 5.74e-01 7.19e-01 0.05810 -0.058100 -2.77e-03 5.20e-01 9.76e-01
Generic-Transcription-Pathway 843 1.96e-02 8.23e-02 0.05800 -0.026700 -5.15e-02 1.92e-01 1.20e-02
Purine-catabolism 16 7.47e-01 8.30e-01 0.05790 -0.008910 5.72e-02 9.51e-01 6.92e-01
PKA-activation-in-glucagon-signalling 15 7.06e-01 8.03e-01 0.05740 0.052200 -2.40e-02 7.26e-01 8.72e-01
Toll-Like-Receptor-4-(TLR4)-Cascade 113 5.30e-01 6.90e-01 0.05670 0.051900 2.27e-02 3.41e-01 6.77e-01
Downstream-signal-transduction 28 9.15e-01 9.40e-01 0.05670 0.033500 4.57e-02 7.59e-01 6.76e-01
Meiotic-recombination 23 8.16e-01 8.69e-01 0.05610 -0.012600 -5.47e-02 9.17e-01 6.50e-01
SUMOylation-of-transcription-cofactors 42 7.15e-01 8.10e-01 0.05590 -0.014700 -5.39e-02 8.69e-01 5.46e-01
Muscle-contraction 148 2.98e-02 1.14e-01 0.05550 -0.043800 3.41e-02 3.59e-01 4.74e-01
Disease 881 8.96e-04 7.40e-03 0.05530 0.053800 1.28e-02 7.31e-03 5.24e-01
SLC-transporter-disorders 65 2.24e-01 4.21e-01 0.05470 0.032400 -4.41e-02 6.51e-01 5.39e-01
Insulin-receptor-signalling-cascade 39 5.65e-01 7.13e-01 0.05420 0.054000 -4.89e-03 5.60e-01 9.58e-01
Resolution-of-Abasic-Sites-(AP-sites) 37 7.68e-01 8.41e-01 0.05350 0.014600 5.14e-02 8.78e-01 5.89e-01
Translesion-synthesis-by-POLI 17 6.84e-01 7.90e-01 0.05320 -0.037400 3.79e-02 7.90e-01 7.87e-01
Signaling-by-Insulin-receptor 58 4.87e-01 6.59e-01 0.05290 0.052900 -7.05e-04 4.86e-01 9.93e-01
Integration-of-energy-metabolism 86 8.10e-01 8.65e-01 0.05220 -0.040500 -3.29e-02 5.16e-01 5.99e-01
Neuronal-System 251 5.35e-01 6.92e-01 0.05180 0.031600 4.10e-02 3.90e-01 2.65e-01
PI3K-Cascade 30 9.35e-01 9.54e-01 0.05160 0.038000 3.49e-02 7.19e-01 7.41e-01
RNA-Polymerase-III-Transcription-Termination 21 6.85e-01 7.90e-01 0.05120 0.047200 -1.98e-02 7.08e-01 8.75e-01
Suppression-of-phagosomal-maturation 13 7.68e-01 8.41e-01 0.05120 0.031100 -4.06e-02 8.46e-01 8.00e-01
Signaling-by-NOTCH1 69 3.62e-01 5.54e-01 0.05000 0.048600 -1.14e-02 4.85e-01 8.70e-01
Translocation-of-SLC2A4-(GLUT4)-to-the-plasma-membrane 51 8.70e-01 9.09e-01 0.04950 -0.027200 -4.13e-02 7.37e-01 6.10e-01
Ca2+-pathway 52 4.67e-01 6.46e-01 0.04920 0.047700 -1.23e-02 5.52e-01 8.78e-01
Activation-of-AMPK-downstream-of-NMDARs 10 8.56e-01 9.00e-01 0.04910 0.015100 -4.68e-02 9.34e-01 7.98e-01
Signaling-by-WNT 233 5.39e-01 6.93e-01 0.04910 -0.027000 -4.10e-02 4.79e-01 2.82e-01
Association-of-TriC/CCT-with-target-proteins-during-biosynthesis 37 6.51e-01 7.60e-01 0.04910 -0.049000 3.23e-03 6.06e-01 9.73e-01
Signaling-by-NOTCH3 46 4.22e-01 6.06e-01 0.04900 0.031300 -3.78e-02 7.14e-01 6.58e-01
TRAF6-mediated-induction-of-NFkB-and-MAP-kinases-upon-TLR7/8-or-9-activation 83 3.69e-01 5.64e-01 0.04890 0.004760 -4.87e-02 9.40e-01 4.44e-01
MyD88-independent-TLR4-cascade 90 2.40e-01 4.38e-01 0.04890 0.045800 -1.71e-02 4.53e-01 7.79e-01
TRIF(TICAM1)-mediated-TLR4-signaling 90 2.40e-01 4.38e-01 0.04890 0.045800 -1.71e-02 4.53e-01 7.79e-01
Synthesis-of-very-long-chain-fatty-acyl-CoAs 18 9.48e-01 9.65e-01 0.04890 0.025000 4.20e-02 8.54e-01 7.58e-01
Intrinsic-Pathway-for-Apoptosis 47 5.75e-01 7.19e-01 0.04850 0.048300 -4.57e-03 5.67e-01 9.57e-01
G-beta:gamma-signalling-through-PLC-beta 14 8.07e-01 8.65e-01 0.04800 0.045000 -1.66e-02 7.71e-01 9.14e-01
Beta-catenin-independent-WNT-signaling 131 7.48e-01 8.30e-01 0.04780 -0.038400 -2.85e-02 4.49e-01 5.73e-01
Toll-Like-Receptor-3-(TLR3)-Cascade 87 2.23e-01 4.21e-01 0.04720 0.029600 -3.67e-02 6.34e-01 5.54e-01
Estrogen-dependent-gene-expression 83 7.31e-01 8.21e-01 0.04710 -0.019400 -4.29e-02 7.60e-01 5.00e-01
Signalling-to-ERKs 30 6.73e-01 7.78e-01 0.04710 0.045700 -1.11e-02 6.65e-01 9.16e-01
Constitutive-Signaling-by-NOTCH1-HD+PEST-Domain-Mutants 57 4.79e-01 6.53e-01 0.04590 0.012100 -4.43e-02 8.74e-01 5.63e-01
Constitutive-Signaling-by-NOTCH1-PEST-Domain-Mutants 57 4.79e-01 6.53e-01 0.04590 0.012100 -4.43e-02 8.74e-01 5.63e-01
Signaling-by-NOTCH1-HD+PEST-Domain-Mutants-in-Cancer 57 4.79e-01 6.53e-01 0.04590 0.012100 -4.43e-02 8.74e-01 5.63e-01
Signaling-by-NOTCH1-PEST-Domain-Mutants-in-Cancer 57 4.79e-01 6.53e-01 0.04590 0.012100 -4.43e-02 8.74e-01 5.63e-01
Signaling-by-NOTCH1-in-Cancer 57 4.79e-01 6.53e-01 0.04590 0.012100 -4.43e-02 8.74e-01 5.63e-01
Oncogene-Induced-Senescence 32 6.72e-01 7.78e-01 0.04520 0.043700 -1.15e-02 6.69e-01 9.10e-01
Costimulation-by-the-CD28-family 52 5.46e-01 6.96e-01 0.04490 -0.009390 4.39e-02 9.07e-01 5.85e-01
Developmental-Biology 654 1.38e-02 6.40e-02 0.04480 0.044400 6.05e-03 5.45e-02 7.93e-01
Hedgehog-'off'-state 93 3.04e-01 5.11e-01 0.04480 -0.042600 1.38e-02 4.78e-01 8.18e-01
G-protein-beta:gamma-signalling 26 7.88e-01 8.52e-01 0.04430 0.044300 -1.97e-03 6.96e-01 9.86e-01
Base-Excision-Repair 44 7.81e-01 8.48e-01 0.04410 0.009330 4.31e-02 9.15e-01 6.21e-01
Signaling-by-ERBB2 47 7.95e-01 8.57e-01 0.04240 0.041200 1.02e-02 6.25e-01 9.04e-01
NOTCH1-Intracellular-Domain-Regulates-Transcription 46 5.54e-01 7.03e-01 0.04190 0.036600 -2.03e-02 6.68e-01 8.11e-01
Infection-with-Mycobacterium-tuberculosis 24 7.30e-01 8.21e-01 0.04170 0.022600 -3.50e-02 8.48e-01 7.67e-01
N-glycan-trimming-in-the-ER-and-Calnexin/Calreticulin-cycle 34 6.41e-01 7.51e-01 0.04160 0.035100 -2.25e-02 7.24e-01 8.21e-01
Regulation-of-insulin-secretion 59 7.56e-01 8.35e-01 0.04120 0.009280 4.01e-02 9.02e-01 5.95e-01
CD209-(DC-SIGN)-signaling 18 9.56e-01 9.68e-01 0.04090 -0.018600 -3.64e-02 8.91e-01 7.89e-01
Insulin-receptor-recycling 20 7.75e-01 8.45e-01 0.04090 0.033800 -2.30e-02 7.94e-01 8.58e-01
ROS-and-RNS-production-in-phagocytes 28 6.97e-01 7.99e-01 0.04090 0.024500 -3.27e-02 8.23e-01 7.64e-01
Resolution-of-AP-sites-via-the-multiple-nucleotide-patch-replacement-pathway 24 7.48e-01 8.30e-01 0.04070 -0.019400 3.57e-02 8.69e-01 7.62e-01
G-alpha-(q)-signalling-events 118 8.50e-01 8.97e-01 0.04050 0.027200 3.00e-02 6.10e-01 5.74e-01
RNA-Polymerase-III-Transcription-Initiation 34 9.55e-01 9.68e-01 0.03990 -0.026300 -3.00e-02 7.91e-01 7.63e-01
Transcriptional-regulation-by-RUNX3 92 3.60e-01 5.53e-01 0.03930 -0.018100 3.49e-02 7.65e-01 5.64e-01
Spry-regulation-of-FGF-signaling 16 9.66e-01 9.75e-01 0.03920 -0.018500 -3.46e-02 8.98e-01 8.11e-01
IRS-mediated-signalling 34 9.21e-01 9.46e-01 0.03910 0.035100 1.71e-02 7.23e-01 8.63e-01
Erythropoietin-activates-RAS 13 8.69e-01 9.08e-01 0.03800 0.019500 -3.27e-02 9.03e-01 8.38e-01
M-Phase 299 3.01e-01 5.09e-01 0.03780 0.036900 8.21e-03 2.74e-01 8.08e-01
MyD88-dependent-cascade-initiated-on-endosome 84 5.40e-01 6.93e-01 0.03780 0.004450 -3.75e-02 9.44e-01 5.53e-01
Toll-Like-Receptor-7/8-(TLR7/8)-Cascade 84 5.40e-01 6.93e-01 0.03780 0.004450 -3.75e-02 9.44e-01 5.53e-01
Toll-Like-Receptor-9-(TLR9)-Cascade 88 4.09e-01 5.96e-01 0.03710 0.018600 -3.21e-02 7.64e-01 6.03e-01
Activated-NOTCH1-Transmits-Signal-to-the-Nucleus 28 7.83e-01 8.49e-01 0.03590 0.013200 -3.34e-02 9.04e-01 7.60e-01
MAPK1/MAPK3-signaling 207 4.71e-01 6.49e-01 0.03580 0.007670 3.50e-02 8.50e-01 3.87e-01
Nicotinate-metabolism 27 7.91e-01 8.55e-01 0.03560 -0.032900 1.36e-02 7.67e-01 9.03e-01
Downregulation-of-ERBB2-signaling 27 7.79e-01 8.47e-01 0.03460 0.027700 -2.08e-02 8.04e-01 8.52e-01
Regulation-of-TP53-Activity 148 5.33e-01 6.91e-01 0.03420 -0.034100 -3.36e-03 4.75e-01 9.44e-01
RNA-Polymerase-III-Abortive-And-Retractive-Initiation 39 7.06e-01 8.03e-01 0.03400 0.027000 -2.06e-02 7.71e-01 8.24e-01
RNA-Polymerase-III-Transcription 39 7.06e-01 8.03e-01 0.03400 0.027000 -2.06e-02 7.71e-01 8.24e-01
SUMOylation 159 4.60e-01 6.39e-01 0.03330 0.033300 -4.64e-04 4.70e-01 9.92e-01
Signaling-by-Erythropoietin 24 8.20e-01 8.73e-01 0.03290 0.027100 -1.87e-02 8.18e-01 8.74e-01
Diseases-of-carbohydrate-metabolism 29 9.74e-01 9.82e-01 0.03280 0.024000 2.24e-02 8.23e-01 8.35e-01
ESR-mediated-signaling 142 3.31e-01 5.31e-01 0.03220 0.027100 -1.74e-02 5.77e-01 7.21e-01
Initial-triggering-of-complement 11 9.59e-01 9.71e-01 0.03150 0.031400 2.45e-03 8.57e-01 9.89e-01
Ion-channel-transport 110 8.09e-01 8.65e-01 0.03120 -0.029100 -1.12e-02 5.98e-01 8.40e-01
HuR-(ELAVL1)-binds-and-stabilizes-mRNA 10 9.86e-01 9.89e-01 0.03100 -0.027300 -1.46e-02 8.81e-01 9.36e-01
RAF/MAP-kinase-cascade 202 4.46e-01 6.30e-01 0.03090 0.000450 3.09e-02 9.91e-01 4.50e-01
Mitotic-G2-G2/M-phases 175 5.02e-01 6.68e-01 0.03080 0.000669 3.08e-02 9.88e-01 4.84e-01
TP53-Regulates-Transcription-of-DNA-Repair-Genes 59 6.62e-01 7.69e-01 0.02990 -0.021700 2.05e-02 7.73e-01 7.86e-01
MyD88:MAL(TIRAP)-cascade-initiated-on-plasma-membrane 88 7.77e-01 8.45e-01 0.02950 -0.004340 -2.91e-02 9.44e-01 6.37e-01
Toll-Like-Receptor-2-(TLR2)-Cascade 88 7.77e-01 8.45e-01 0.02950 -0.004340 -2.91e-02 9.44e-01 6.37e-01
Toll-Like-Receptor-TLR1:TLR2-Cascade 88 7.77e-01 8.45e-01 0.02950 -0.004340 -2.91e-02 9.44e-01 6.37e-01
Toll-Like-Receptor-TLR6:TLR2-Cascade 88 7.77e-01 8.45e-01 0.02950 -0.004340 -2.91e-02 9.44e-01 6.37e-01
SUMO-E3-ligases-SUMOylate-target-proteins 153 4.41e-01 6.26e-01 0.02830 0.026400 -1.02e-02 5.73e-01 8.28e-01
S-Phase 152 4.25e-01 6.08e-01 0.02750 -0.023400 1.45e-02 6.19e-01 7.58e-01
Diseases-of-signal-transduction 331 7.58e-01 8.35e-01 0.02730 0.023000 1.47e-02 4.75e-01 6.47e-01
Formation-of-the-beta-catenin:TCF-transactivating-complex 31 9.77e-01 9.82e-01 0.02670 0.021900 1.52e-02 8.33e-01 8.83e-01
Recognition-of-DNA-damage-by-PCNA-containing-replication-complex 29 8.82e-01 9.19e-01 0.02650 -0.025600 7.04e-03 8.12e-01 9.48e-01
Mitotic-Metaphase-and-Anaphase 165 8.98e-01 9.29e-01 0.02610 0.020900 1.56e-02 6.44e-01 7.30e-01
Positive-epigenetic-regulation-of-rRNA-expression 46 9.24e-01 9.47e-01 0.02580 -0.024900 -6.71e-03 7.70e-01 9.37e-01
Signaling-by-NOTCH 164 8.98e-01 9.29e-01 0.02560 -0.020800 -1.50e-02 6.46e-01 7.41e-01
DNA-Repair 271 6.31e-01 7.50e-01 0.02550 -0.024700 -6.29e-03 4.86e-01 8.59e-01
Epigenetic-regulation-of-gene-expression 87 7.52e-01 8.33e-01 0.02520 0.025000 -3.03e-03 6.88e-01 9.61e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-3-Promoter 26 8.83e-01 9.19e-01 0.02500 -0.014300 2.05e-02 9.00e-01 8.57e-01
p38MAPK-events 12 9.50e-01 9.65e-01 0.02460 0.010500 -2.23e-02 9.50e-01 8.94e-01
MECP2-regulates-neuronal-receptors-and-channels 12 9.78e-01 9.82e-01 0.02400 0.023700 3.68e-03 8.87e-01 9.82e-01
Netrin-1-signaling 39 9.05e-01 9.34e-01 0.02360 -0.023600 8.40e-04 7.99e-01 9.93e-01
Mitotic-Anaphase 164 9.14e-01 9.39e-01 0.02340 0.019000 1.36e-02 6.75e-01 7.65e-01
G2/M-Transition 173 5.61e-01 7.10e-01 0.02260 -0.007700 2.12e-02 8.62e-01 6.30e-01
FLT3-Signaling 220 5.31e-01 6.90e-01 0.02240 -0.004790 2.19e-02 9.03e-01 5.77e-01
SUMOylation-of-DNA-replication-proteins 45 8.60e-01 9.01e-01 0.02240 0.020900 -8.05e-03 8.09e-01 9.26e-01
PKMTs-methylate-histone-lysines 42 9.81e-01 9.85e-01 0.02100 -0.017300 -1.21e-02 8.47e-01 8.92e-01
Separation-of-Sister-Chromatids 154 9.23e-01 9.46e-01 0.02040 0.010400 1.76e-02 8.24e-01 7.07e-01
Ca-dependent-events 32 9.35e-01 9.54e-01 0.02010 0.019900 -2.53e-03 8.45e-01 9.80e-01
rRNA-processing-in-the-nucleus-and-cytosol 156 9.28e-01 9.50e-01 0.01920 0.009540 1.66e-02 8.37e-01 7.20e-01
NOTCH2-Activation-and-Transmission-of-Signal-to-the-Nucleus 21 9.75e-01 9.82e-01 0.01900 0.018900 2.71e-03 8.81e-01 9.83e-01
DNA-Double-Strand-Break-Repair 123 7.36e-01 8.23e-01 0.01800 -0.011000 1.42e-02 8.33e-01 7.86e-01
Adaptive-Immune-System 558 5.24e-01 6.87e-01 0.01720 0.017100 6.61e-04 4.91e-01 9.79e-01
FGFR1-mutant-receptor-activation 25 9.76e-01 9.82e-01 0.01630 -0.001540 -1.63e-02 9.89e-01 8.88e-01
Apoptosis 152 8.29e-01 8.80e-01 0.01420 -0.013700 3.72e-03 7.70e-01 9.37e-01
Major-pathway-of-rRNA-processing-in-the-nucleolus-and-cytosol 147 9.54e-01 9.68e-01 0.01350 0.005440 1.24e-02 9.09e-01 7.96e-01
Inactivation,-recovery-and-regulation-of-the-phototransduction-cascade 17 9.97e-01 9.97e-01 0.01260 -0.010400 -7.04e-03 9.41e-01 9.60e-01
The-phototransduction-cascade 17 9.97e-01 9.97e-01 0.01260 -0.010400 -7.04e-03 9.41e-01 9.60e-01
CaM-pathway 30 9.64e-01 9.73e-01 0.01250 0.008680 -9.04e-03 9.34e-01 9.32e-01
Calmodulin-induced-events 30 9.64e-01 9.73e-01 0.01250 0.008680 -9.04e-03 9.34e-01 9.32e-01
Glucagon-like-Peptide-1-(GLP1)-regulates-insulin-secretion 31 9.87e-01 9.89e-01 0.01040 0.000508 1.04e-02 9.96e-01 9.20e-01
Opioid-Signalling 72 9.68e-01 9.76e-01 0.00783 0.003990 -6.74e-03 9.53e-01 9.21e-01
Programmed-Cell-Death 155 9.53e-01 9.68e-01 0.00777 -0.000879 7.72e-03 9.85e-01 8.69e-01
NOD1/2-Signaling-Pathway 28 9.91e-01 9.93e-01 0.00721 0.001710 -7.00e-03 9.87e-01 9.49e-01


Detailed Gene set reports


Formation-of-ATP-by-chemiosmotic-coupling

Formation-of-ATP-by-chemiosmotic-coupling
metric value
setSize 16
pMANOVA 1.29e-10
p.adjustMANOVA 4.72e-09
s.dist 1.31
s.young -0.933
s.old -0.919
p.young 1.02e-10
p.old 1.89e-10




Top 20 genes
Gene young old
Atp5o -7347 -7794
Atp5l -7340 -7690
Atp5pb -7213 -7607
Atp5g3 -7235 -7573
Atp5a1 -7220 -7504
Atp5c1 -7207 -7515
Atp5h -7284 -7352
Atp5j -7206 -7420
Atp5b -7224 -7258
mt-Atp6 -7229 -7101
Atp5j2 -7093 -7135
Dmac2l -6520 -7171
Atp5d -7173 -6303
Atp5e -7150 -6015
Atp5k -5830 -7288
mt-Atp8 -3257 -6724

Click HERE to show all gene set members

All member genes
young old
Atp5a1 -7220 -7504
Atp5b -7224 -7258
Atp5c1 -7207 -7515
Atp5d -7173 -6303
Atp5e -7150 -6015
Atp5g3 -7235 -7573
Atp5h -7284 -7352
Atp5j -7206 -7420
Atp5j2 -7093 -7135
Atp5k -5830 -7288
Atp5l -7340 -7690
Atp5o -7347 -7794
Atp5pb -7213 -7607
Dmac2l -6520 -7171
mt-Atp6 -7229 -7101
mt-Atp8 -3257 -6724



Complex-I-biogenesis

Complex-I-biogenesis
metric value
setSize 54
pMANOVA 1.62e-33
p.adjustMANOVA 2.07e-31
s.dist 1.3
s.young -0.93
s.old -0.904
p.young 2.28e-32
p.old 1.25e-30




Top 20 genes
Gene young old
Ndufb8 -7343 -7800
Ndufc2 -7325 -7719
Ndufa9 -7317 -7720
Ndufv2 -7260 -7683
Ndufa10 -7288 -7572
Ndufs4 -7275 -7583
Ndufs2 -7314 -7534
Ndufa5 -7189 -7647
Ndufab1 -7247 -7579
Ndufs3 -7291 -7530
Ndufa7 -7328 -7459
Ndufs1 -7157 -7633
Ndufa11 -7330 -7448
mt-Nd2 -7271 -7495
Ndufs6 -7098 -7550
Ndufs8 -7303 -7304
mt-Nd1 -7119 -7489
Ndufaf1 -7011 -7559
Ndufa12 -7240 -7308
Ndufa3 -7000 -7510

Click HERE to show all gene set members

All member genes
young old
Acad9 -6612 -6647
Ecsit -6908 -6444
mt-Nd1 -7119 -7489
mt-Nd2 -7271 -7495
mt-Nd3 -6642 -5922
mt-Nd4 -6682 -7382
mt-Nd5 -6386 -7564
mt-Nd6 -6677 -7251
Ndufa1 -5430 -6709
Ndufa10 -7288 -7572
Ndufa11 -7330 -7448
Ndufa12 -7240 -7308
Ndufa13 -7053 -7089
Ndufa2 -6895 -6030
Ndufa3 -7000 -7510
Ndufa5 -7189 -7647
Ndufa6 -6698 -7117
Ndufa7 -7328 -7459
Ndufa8 -7315 -7154
Ndufa9 -7317 -7720
Ndufab1 -7247 -7579
Ndufaf1 -7011 -7559
Ndufaf2 -4758 -5261
Ndufaf3 -4910 -5440
Ndufaf4 -6419 -7254
Ndufaf5 -5750 -6463
Ndufaf6 -6271 -7083
Ndufaf7 -5738 -6678
Ndufb1-ps -5319 -6906
Ndufb10 -7199 -7209
Ndufb2 -7214 -7114
Ndufb3 -6549 -6607
Ndufb4 -7132 -7245
Ndufb5 -7181 -6935
Ndufb6 -6950 -7112
Ndufb7 -7225 -6331
Ndufb8 -7343 -7800
Ndufb9 -7140 -7223
Ndufc1 -6951 -7311
Ndufc2 -7325 -7719
Ndufs1 -7157 -7633
Ndufs2 -7314 -7534
Ndufs3 -7291 -7530
Ndufs4 -7275 -7583
Ndufs5 -7010 -7087
Ndufs6 -7098 -7550
Ndufs7 -7258 -6981
Ndufs8 -7303 -7304
Ndufv1 -7186 -6904
Ndufv2 -7260 -7683
Ndufv3 -7034 -7419
Nubpl -6153 -6907
Timmdc1 -6360 -5463
Tmem126b -5883 -7021



Citric-acid-cycle-(TCA-cycle)

Citric-acid-cycle-(TCA-cycle)
metric value
setSize 22
pMANOVA 2.51e-13
p.adjustMANOVA 1.53e-11
s.dist 1.26
s.young -0.894
s.old -0.889
p.young 3.71e-13
p.old 5.02e-13




Top 20 genes
Gene young old
Sdha -7346 -7813
Sdhd -7333 -7791
Sucla2 -7292 -7689
Suclg2 -7193 -7724
Idh3b -7322 -7586
Dld -7216 -7696
Suclg1 -7259 -7645
Dlst -7165 -7693
Cs -7238 -7580
Sdhb -7295 -7485
Idh3a -7085 -7634
Nnt -6917 -7798
Sdhc -7227 -7405
Me3 -7147 -7472
Fahd1 -7052 -7556
Fh1 -7115 -7449
Idh3g -7228 -7314
Ogdh -7013 -7475
Mdh2 -7233 -7179
Idh2 -6961 -7381

Click HERE to show all gene set members

All member genes
young old
Aco2 -6436 -6977
Cs -7238 -7580
Dld -7216 -7696
Dlst -7165 -7693
Fahd1 -7052 -7556
Fh1 -7115 -7449
Idh2 -6961 -7381
Idh3a -7085 -7634
Idh3b -7322 -7586
Idh3g -7228 -7314
Mdh2 -7233 -7179
Me2 5856 4582
Me3 -7147 -7472
Nnt -6917 -7798
Ogdh -7013 -7475
Sdha -7346 -7813
Sdhb -7295 -7485
Sdhc -7227 -7405
Sdhd -7333 -7791
Sucla2 -7292 -7689
Suclg1 -7259 -7645
Suclg2 -7193 -7724



Cristae-formation

Cristae-formation
metric value
setSize 29
pMANOVA 4.27e-17
p.adjustMANOVA 3.22e-15
s.dist 1.25
s.young -0.905
s.old -0.861
p.young 3.21e-17
p.old 9.79e-16




Top 20 genes
Gene young old
Atp5o -7347 -7794
Atp5l -7340 -7690
Immt -7219 -7621
Atp5pb -7213 -7607
Atp5g3 -7235 -7573
Atp5a1 -7220 -7504
Atp5c1 -7207 -7515
Hspa9 -7037 -7692
Atp5h -7284 -7352
Atp5j -7206 -7420
Apoo -7092 -7482
Atp5b -7224 -7258
mt-Atp6 -7229 -7101
Chchd3 -7066 -7212
Atp5j2 -7093 -7135
Samm50 -7217 -6662
Dmac2l -6520 -7171
Atp5d -7173 -6303
Micos10 -7129 -6291
Mtx2 -6403 -6945

Click HERE to show all gene set members

All member genes
young old
Apoo -7092 -7482
Apool -5925 -6704
Atp5a1 -7220 -7504
Atp5b -7224 -7258
Atp5c1 -7207 -7515
Atp5d -7173 -6303
Atp5e -7150 -6015
Atp5g3 -7235 -7573
Atp5h -7284 -7352
Atp5j -7206 -7420
Atp5j2 -7093 -7135
Atp5k -5830 -7288
Atp5l -7340 -7690
Atp5o -7347 -7794
Atp5pb -7213 -7607
Chchd3 -7066 -7212
Chchd6 -3301 -2838
Dmac2l -6520 -7171
Dnajc11 -6412 -6403
Hspa9 -7037 -7692
Immt -7219 -7621
Micos10 -7129 -6291
Micos13 -6641 -6011
mt-Atp6 -7229 -7101
mt-Atp8 -3257 -6724
Mtx1 -5805 -4557
Mtx2 -6403 -6945
Samm50 -7217 -6662
Tmem11 -5461 -4602



Respiratory-electron-transport

Respiratory-electron-transport
metric value
setSize 100
pMANOVA 4.63e-57
p.adjustMANOVA 1.97e-54
s.dist 1.25
s.young -0.904
s.old -0.859
p.young 2.8e-55
p.old 4.76e-50




Top 20 genes
Gene young old
Sdha -7346 -7813
Ndufb8 -7343 -7800
Sdhd -7333 -7791
Etfa -7323 -7764
Etfdh -7269 -7789
Ndufc2 -7325 -7719
Ndufa9 -7317 -7720
Uqcr11 -7327 -7657
Ndufv2 -7260 -7683
Uqcrfs1 -7311 -7599
Uqcrh -7334 -7571
Etfb -7336 -7558
mt-Co1 -7257 -7632
Ndufa10 -7288 -7572
Ndufs4 -7275 -7583
Ndufs2 -7314 -7534
Ndufa5 -7189 -7647
Ndufab1 -7247 -7579
Ndufs3 -7291 -7530
Uqcrc2 -7191 -7618

Click HERE to show all gene set members

All member genes
young old
Acad9 -6612 -6647
Coq10a -7209 -7269
Coq10b -5270 -2925
Cox11 -4941 -6003
Cox14 -7095 -6340
Cox16 -5100 -3654
Cox18 -4863 -4177
Cox19 6674 6213
Cox20 -4854 -5240
Cox4i1 -7272 -7222
Cox5a -7164 -7617
Cox5b -6986 -7126
Cox6a1 -5249 -3806
Cox6b1 -7136 -6612
Cox6c -7114 -7331
Cox7a2l -6270 -6466
Cox7b -7084 -7330
Cox7c -6438 -7237
Cox8a -3627 -1367
Cyc1 -7237 -7220
Cycs -7133 -7302
Ecsit -6908 -6444
Etfa -7323 -7764
Etfb -7336 -7558
Etfdh -7269 -7789
Lrpprc -7024 -7746
mt-Co1 -7257 -7632
mt-Co2 -7163 -6523
mt-Co3 -7307 -7023
mt-Cytb -6947 -7620
mt-Nd1 -7119 -7489
mt-Nd2 -7271 -7495
mt-Nd3 -6642 -5922
mt-Nd4 -6682 -7382
mt-Nd5 -6386 -7564
mt-Nd6 -6677 -7251
Ndufa1 -5430 -6709
Ndufa10 -7288 -7572
Ndufa11 -7330 -7448
Ndufa12 -7240 -7308
Ndufa13 -7053 -7089
Ndufa2 -6895 -6030
Ndufa3 -7000 -7510
Ndufa4 -7274 -7232
Ndufa5 -7189 -7647
Ndufa6 -6698 -7117
Ndufa7 -7328 -7459
Ndufa8 -7315 -7154
Ndufa9 -7317 -7720
Ndufab1 -7247 -7579
Ndufaf1 -7011 -7559
Ndufaf2 -4758 -5261
Ndufaf3 -4910 -5440
Ndufaf4 -6419 -7254
Ndufaf5 -5750 -6463
Ndufaf6 -6271 -7083
Ndufaf7 -5738 -6678
Ndufb1-ps -5319 -6906
Ndufb10 -7199 -7209
Ndufb2 -7214 -7114
Ndufb3 -6549 -6607
Ndufb4 -7132 -7245
Ndufb5 -7181 -6935
Ndufb6 -6950 -7112
Ndufb7 -7225 -6331
Ndufb8 -7343 -7800
Ndufb9 -7140 -7223
Ndufc1 -6951 -7311
Ndufc2 -7325 -7719
Ndufs1 -7157 -7633
Ndufs2 -7314 -7534
Ndufs3 -7291 -7530
Ndufs4 -7275 -7583
Ndufs5 -7010 -7087
Ndufs6 -7098 -7550
Ndufs7 -7258 -6981
Ndufs8 -7303 -7304
Ndufv1 -7186 -6904
Ndufv2 -7260 -7683
Ndufv3 -7034 -7419
Nubpl -6153 -6907
Sco1 -6462 -6322
Sco2 -3709 -4161
Sdha -7346 -7813
Sdhb -7295 -7485
Sdhc -7227 -7405
Sdhd -7333 -7791
Surf1 -5087 -5645
Taco1 -6970 -7208
Timmdc1 -6360 -5463
Tmem126b -5883 -7021
Trap1 -6975 -6844
Uqcr10 -6171 -4525
Uqcr11 -7327 -7657
Uqcrb -6857 -7389
Uqcrc1 -7297 -7415
Uqcrc2 -7191 -7618
Uqcrfs1 -7311 -7599
Uqcrh -7334 -7571
Uqcrq -7158 -7033



Branched-chain-amino-acid-catabolism

Branched-chain-amino-acid-catabolism
metric value
setSize 19
pMANOVA 5.85e-11
p.adjustMANOVA 2.49e-09
s.dist 1.22
s.young -0.859
s.old -0.871
p.young 9.04e-11
p.old 4.89e-11




Top 20 genes
Gene young old
Bckdha -7342 -7803
Hibadh -7283 -7717
Acat1 -7263 -7711
Dld -7216 -7696
Mccc2 -7174 -7704
Ivd -7138 -7712
Aldh6a1 -6998 -7778
Mccc1 -6826 -7722
Bckdhb -6907 -7611
Bcat2 -6905 -7609
Auh -6904 -7596
Ppm1k -6684 -7715
Hsd17b10 -6937 -7410
Dbt -6615 -7756
Hibch -6982 -7198
Acad8 -6496 -7039
Acadsb -5889 -7297
Bckdk -6679 -6373

Click HERE to show all gene set members

All member genes
young old
Acad8 -6496 -7039
Acadsb -5889 -7297
Acat1 -7263 -7711
Aldh6a1 -6998 -7778
Auh -6904 -7596
Bcat1 4700 5242
Bcat2 -6905 -7609
Bckdha -7342 -7803
Bckdhb -6907 -7611
Bckdk -6679 -6373
Dbt -6615 -7756
Dld -7216 -7696
Hibadh -7283 -7717
Hibch -6982 -7198
Hsd17b10 -6937 -7410
Ivd -7138 -7712
Mccc1 -6826 -7722
Mccc2 -7174 -7704
Ppm1k -6684 -7715



Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.

Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.
metric value
setSize 120
pMANOVA 4.61e-65
p.adjustMANOVA 2.95e-62
s.dist 1.22
s.young -0.883
s.old -0.836
p.young 5.28e-63
p.old 1.12e-56




Top 20 genes
Gene young old
Sdha -7346 -7813
Ndufb8 -7343 -7800
Atp5o -7347 -7794
Sdhd -7333 -7791
Etfa -7323 -7764
Etfdh -7269 -7789
Ndufc2 -7325 -7719
Ndufa9 -7317 -7720
Atp5l -7340 -7690
Uqcr11 -7327 -7657
Ndufv2 -7260 -7683
Uqcrfs1 -7311 -7599
Uqcrh -7334 -7571
Etfb -7336 -7558
mt-Co1 -7257 -7632
Ndufa10 -7288 -7572
Ndufs4 -7275 -7583
Ndufs2 -7314 -7534
Ndufa5 -7189 -7647
Ndufab1 -7247 -7579

Click HERE to show all gene set members

All member genes
young old
Acad9 -6612 -6647
Atp5a1 -7220 -7504
Atp5b -7224 -7258
Atp5c1 -7207 -7515
Atp5d -7173 -6303
Atp5e -7150 -6015
Atp5g3 -7235 -7573
Atp5h -7284 -7352
Atp5j -7206 -7420
Atp5j2 -7093 -7135
Atp5k -5830 -7288
Atp5l -7340 -7690
Atp5o -7347 -7794
Atp5pb -7213 -7607
Coq10a -7209 -7269
Coq10b -5270 -2925
Cox11 -4941 -6003
Cox14 -7095 -6340
Cox16 -5100 -3654
Cox18 -4863 -4177
Cox19 6674 6213
Cox20 -4854 -5240
Cox4i1 -7272 -7222
Cox5a -7164 -7617
Cox5b -6986 -7126
Cox6a1 -5249 -3806
Cox6b1 -7136 -6612
Cox6c -7114 -7331
Cox7a2l -6270 -6466
Cox7b -7084 -7330
Cox7c -6438 -7237
Cox8a -3627 -1367
Cyc1 -7237 -7220
Cycs -7133 -7302
Dmac2l -6520 -7171
Ecsit -6908 -6444
Etfa -7323 -7764
Etfb -7336 -7558
Etfdh -7269 -7789
Lrpprc -7024 -7746
mt-Atp6 -7229 -7101
mt-Atp8 -3257 -6724
mt-Co1 -7257 -7632
mt-Co2 -7163 -6523
mt-Co3 -7307 -7023
mt-Cytb -6947 -7620
mt-Nd1 -7119 -7489
mt-Nd2 -7271 -7495
mt-Nd3 -6642 -5922
mt-Nd4 -6682 -7382
mt-Nd5 -6386 -7564
mt-Nd6 -6677 -7251
Ndufa1 -5430 -6709
Ndufa10 -7288 -7572
Ndufa11 -7330 -7448
Ndufa12 -7240 -7308
Ndufa13 -7053 -7089
Ndufa2 -6895 -6030
Ndufa3 -7000 -7510
Ndufa4 -7274 -7232
Ndufa5 -7189 -7647
Ndufa6 -6698 -7117
Ndufa7 -7328 -7459
Ndufa8 -7315 -7154
Ndufa9 -7317 -7720
Ndufab1 -7247 -7579
Ndufaf1 -7011 -7559
Ndufaf2 -4758 -5261
Ndufaf3 -4910 -5440
Ndufaf4 -6419 -7254
Ndufaf5 -5750 -6463
Ndufaf6 -6271 -7083
Ndufaf7 -5738 -6678
Ndufb1-ps -5319 -6906
Ndufb10 -7199 -7209
Ndufb2 -7214 -7114
Ndufb3 -6549 -6607
Ndufb4 -7132 -7245
Ndufb5 -7181 -6935
Ndufb6 -6950 -7112
Ndufb7 -7225 -6331
Ndufb8 -7343 -7800
Ndufb9 -7140 -7223
Ndufc1 -6951 -7311
Ndufc2 -7325 -7719
Ndufs1 -7157 -7633
Ndufs2 -7314 -7534
Ndufs3 -7291 -7530
Ndufs4 -7275 -7583
Ndufs5 -7010 -7087
Ndufs6 -7098 -7550
Ndufs7 -7258 -6981
Ndufs8 -7303 -7304
Ndufv1 -7186 -6904
Ndufv2 -7260 -7683
Ndufv3 -7034 -7419
Nubpl -6153 -6907
Sco1 -6462 -6322
Sco2 -3709 -4161
Sdha -7346 -7813
Sdhb -7295 -7485
Sdhc -7227 -7405
Sdhd -7333 -7791
Slc25a14 4008 2705
Slc25a27 1019 1297
Surf1 -5087 -5645
Taco1 -6970 -7208
Timmdc1 -6360 -5463
Tmem126b -5883 -7021
Trap1 -6975 -6844
Ucp2 -3935 3288
Ucp3 -3606 -5388
Uqcr10 -6171 -4525
Uqcr11 -7327 -7657
Uqcrb -6857 -7389
Uqcrc1 -7297 -7415
Uqcrc2 -7191 -7618
Uqcrfs1 -7311 -7599
Uqcrh -7334 -7571
Uqcrq -7158 -7033



Mitochondrial-Fatty-Acid-Beta-Oxidation

Mitochondrial-Fatty-Acid-Beta-Oxidation
metric value
setSize 31
pMANOVA 5.13e-17
p.adjustMANOVA 3.65e-15
s.dist 1.21
s.young -0.858
s.old -0.85
p.young 1.25e-16
p.old 2.49e-16




Top 20 genes
Gene young old
Hadh -7309 -7774
Acaa2 -7293 -7768
Eci1 -7341 -7716
Hadhb -7300 -7759
Acot2 -7253 -7797
Decr1 -7267 -7777
Echs1 -7313 -7662
Hadha -7254 -7673
Ndufab1 -7247 -7579
Acad11 -7134 -7691
Acadvl -7306 -7500
Acadm -7198 -7598
Mmut -7065 -7739
Pcca -7022 -7738
Mcee -7015 -7616
Acads -7280 -7250
Pccb -7054 -7359
Acadl -6920 -7478
Acot13 -7060 -7028
Acot11 -6459 -7215

Click HERE to show all gene set members

All member genes
young old
Acaa2 -7293 -7768
Acad11 -7134 -7691
Acad12 -6749 -6851
Acadl -6920 -7478
Acadm -7198 -7598
Acads -7280 -7250
Acadvl -7306 -7500
Acbd6 -5225 -2979
Acot11 -6459 -7215
Acot13 -7060 -7028
Acot2 -7253 -7797
Acot7 -5971 -6960
Acot9 7045 6582
Acsf2 -5910 -7231
Dbi -6324 -6808
Decr1 -7267 -7777
Echs1 -7313 -7662
Eci1 -7341 -7716
Hadh -7309 -7774
Hadha -7254 -7673
Hadhb -7300 -7759
Mcat -6474 -6636
Mcee -7015 -7616
Mecr -6170 -6438
Mmaa -6691 -6758
Mmut -7065 -7739
Ndufab1 -7247 -7579
Pcca -7022 -7738
Pccb -7054 -7359
Pctp -3512 -6069
Them4 -5770 -5601



The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport

The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport
metric value
setSize 167
pMANOVA 1.25e-82
p.adjustMANOVA 1.6e-79
s.dist 1.17
s.young -0.835
s.old -0.813
p.young 5.14e-78
p.old 5.46e-74




Top 20 genes
Gene young old
Adhfe1 -7349 -7821
Ldhb -7348 -7811
Sdha -7346 -7813
Ndufb8 -7343 -7800
Atp5o -7347 -7794
Sdhd -7333 -7791
Etfa -7323 -7764
Etfdh -7269 -7789
Ndufc2 -7325 -7719
Ndufa9 -7317 -7720
Atp5l -7340 -7690
Uqcr11 -7327 -7657
Sucla2 -7292 -7689
Mpc2 -7294 -7670
Ndufv2 -7260 -7683
Suclg2 -7193 -7724
Uqcrfs1 -7311 -7599
Idh3b -7322 -7586
Dld -7216 -7696
Uqcrh -7334 -7571

Click HERE to show all gene set members

All member genes
young old
Acad9 -6612 -6647
Aco2 -6436 -6977
Adhfe1 -7349 -7821
Atp5a1 -7220 -7504
Atp5b -7224 -7258
Atp5c1 -7207 -7515
Atp5d -7173 -6303
Atp5e -7150 -6015
Atp5g3 -7235 -7573
Atp5h -7284 -7352
Atp5j -7206 -7420
Atp5j2 -7093 -7135
Atp5k -5830 -7288
Atp5l -7340 -7690
Atp5o -7347 -7794
Atp5pb -7213 -7607
Bsg -6548 -7267
Coq10a -7209 -7269
Coq10b -5270 -2925
Cox11 -4941 -6003
Cox14 -7095 -6340
Cox16 -5100 -3654
Cox18 -4863 -4177
Cox19 6674 6213
Cox20 -4854 -5240
Cox4i1 -7272 -7222
Cox5a -7164 -7617
Cox5b -6986 -7126
Cox6a1 -5249 -3806
Cox6b1 -7136 -6612
Cox6c -7114 -7331
Cox7a2l -6270 -6466
Cox7b -7084 -7330
Cox7c -6438 -7237
Cox8a -3627 -1367
Cs -7238 -7580
Cyc1 -7237 -7220
Cycs -7133 -7302
D2hgdh -7104 -7565
Dlat -7003 -7332
Dld -7216 -7696
Dlst -7165 -7693
Dmac2l -6520 -7171
Ecsit -6908 -6444
Etfa -7323 -7764
Etfb -7336 -7558
Etfdh -7269 -7789
Fahd1 -7052 -7556
Fh1 -7115 -7449
Glo1 -5689 -5454
Gstz1 -6066 -6846
Hagh 3129 -1329
Idh2 -6961 -7381
Idh3a -7085 -7634
Idh3b -7322 -7586
Idh3g -7228 -7314
L2hgdh -6879 -7484
Ldha 3559 -4312
Ldhb -7348 -7811
Lrpprc -7024 -7746
Mdh2 -7233 -7179
Me1 -6765 -6942
Me2 5856 4582
Me3 -7147 -7472
Mpc1 -7043 -7036
Mpc2 -7294 -7670
mt-Atp6 -7229 -7101
mt-Atp8 -3257 -6724
mt-Co1 -7257 -7632
mt-Co2 -7163 -6523
mt-Co3 -7307 -7023
mt-Cytb -6947 -7620
mt-Nd1 -7119 -7489
mt-Nd2 -7271 -7495
mt-Nd3 -6642 -5922
mt-Nd4 -6682 -7382
mt-Nd5 -6386 -7564
mt-Nd6 -6677 -7251
Ndufa1 -5430 -6709
Ndufa10 -7288 -7572
Ndufa11 -7330 -7448
Ndufa12 -7240 -7308
Ndufa13 -7053 -7089
Ndufa2 -6895 -6030
Ndufa3 -7000 -7510
Ndufa4 -7274 -7232
Ndufa5 -7189 -7647
Ndufa6 -6698 -7117
Ndufa7 -7328 -7459
Ndufa8 -7315 -7154
Ndufa9 -7317 -7720
Ndufab1 -7247 -7579
Ndufaf1 -7011 -7559
Ndufaf2 -4758 -5261
Ndufaf3 -4910 -5440
Ndufaf4 -6419 -7254
Ndufaf5 -5750 -6463
Ndufaf6 -6271 -7083
Ndufaf7 -5738 -6678
Ndufb1-ps -5319 -6906
Ndufb10 -7199 -7209
Ndufb2 -7214 -7114
Ndufb3 -6549 -6607
Ndufb4 -7132 -7245
Ndufb5 -7181 -6935
Ndufb6 -6950 -7112
Ndufb7 -7225 -6331
Ndufb8 -7343 -7800
Ndufb9 -7140 -7223
Ndufc1 -6951 -7311
Ndufc2 -7325 -7719
Ndufs1 -7157 -7633
Ndufs2 -7314 -7534
Ndufs3 -7291 -7530
Ndufs4 -7275 -7583
Ndufs5 -7010 -7087
Ndufs6 -7098 -7550
Ndufs7 -7258 -6981
Ndufs8 -7303 -7304
Ndufv1 -7186 -6904
Ndufv2 -7260 -7683
Ndufv3 -7034 -7419
Nnt -6917 -7798
Nubpl -6153 -6907
Ogdh -7013 -7475
Pdha1 -7106 -7283
Pdhb -7169 -7319
Pdhx -7172 -7679
Pdk1 4156 -6364
Pdk2 -6889 -7055
Pdk3 6805 6440
Pdk4 -1655 1645
Pdp1 -4181 -5275
Pdp2 -5917 -7570
Pdpr -5996 -7506
Ppard -5588 -4490
Rxra -6194 -6804
Sco1 -6462 -6322
Sco2 -3709 -4161
Sdha -7346 -7813
Sdhb -7295 -7485
Sdhc -7227 -7405
Sdhd -7333 -7791
Slc16a1 -5936 -4200
Slc16a3 7305 6044
Slc16a8 -4482 -3791
Slc25a14 4008 2705
Slc25a27 1019 1297
Sucla2 -7292 -7689
Suclg1 -7259 -7645
Suclg2 -7193 -7724
Surf1 -5087 -5645
Taco1 -6970 -7208
Timmdc1 -6360 -5463
Tmem126b -5883 -7021
Trap1 -6975 -6844
Ucp2 -3935 3288
Ucp3 -3606 -5388
Uqcr10 -6171 -4525
Uqcr11 -7327 -7657
Uqcrb -6857 -7389
Uqcrc1 -7297 -7415
Uqcrc2 -7191 -7618
Uqcrfs1 -7311 -7599
Uqcrh -7334 -7571
Uqcrq -7158 -7033
Vdac1 -7008 -7195



rRNA-processing-in-the-mitochondrion

rRNA-processing-in-the-mitochondrion
metric value
setSize 22
pMANOVA 1.56e-11
p.adjustMANOVA 7.41e-10
s.dist 1.16
s.young -0.783
s.old -0.854
p.young 2e-10
p.old 3.93e-12




Top 20 genes
Gene young old
mt-Co1 -7257 -7632
mt-Nd2 -7271 -7495
mt-Nd1 -7119 -7489
mt-Cytb -6947 -7620
Hsd17b10 -6937 -7410
mt-Atp6 -7229 -7101
mt-Co3 -7307 -7023
Mrm2 -6671 -7643
mt-Nd4 -6682 -7382
mt-Nd5 -6386 -7564
mt-Co2 -7163 -6523
Nsun4 -6285 -7386
Mrm3 -6893 -6717
mt-Nd3 -6642 -5922
Mterf4 -5779 -6241
Trmt10c -5141 -6714
mt-Nd4l -3936 -7494
mt-Atp8 -3257 -6724
Tfb1m -3569 -5783
Mrm1 -4507 -4469

Click HERE to show all gene set members

All member genes
young old
Elac2 -4160 -4011
Hsd17b10 -6937 -7410
Mrm1 -4507 -4469
Mrm2 -6671 -7643
Mrm3 -6893 -6717
mt-Atp6 -7229 -7101
mt-Atp8 -3257 -6724
mt-Co1 -7257 -7632
mt-Co2 -7163 -6523
mt-Co3 -7307 -7023
mt-Cytb -6947 -7620
mt-Nd1 -7119 -7489
mt-Nd2 -7271 -7495
mt-Nd3 -6642 -5922
mt-Nd4 -6682 -7382
mt-Nd4l -3936 -7494
mt-Nd5 -6386 -7564
Mterf4 -5779 -6241
Nsun4 -6285 -7386
Prorp 1087 -5691
Tfb1m -3569 -5783
Trmt10c -5141 -6714



tRNA-processing-in-the-mitochondrion

tRNA-processing-in-the-mitochondrion
metric value
setSize 18
pMANOVA 3.43e-09
p.adjustMANOVA 1.18e-07
s.dist 1.13
s.young -0.75
s.old -0.842
p.young 3.52e-08
p.old 6.26e-10




Top 20 genes
Gene young old
mt-Co1 -7257 -7632
mt-Nd2 -7271 -7495
mt-Nd1 -7119 -7489
mt-Cytb -6947 -7620
Hsd17b10 -6937 -7410
mt-Atp6 -7229 -7101
mt-Co3 -7307 -7023
mt-Nd4 -6682 -7382
mt-Nd6 -6677 -7251
mt-Nd5 -6386 -7564
mt-Co2 -7163 -6523
mt-Nd3 -6642 -5922
Trmt10c -5141 -6714
mt-Nd4l -3936 -7494
mt-Atp8 -3257 -6724
Elac2 -4160 -4011

Click HERE to show all gene set members

All member genes
young old
Elac2 -4160 -4011
Hsd17b10 -6937 -7410
mt-Atp6 -7229 -7101
mt-Atp8 -3257 -6724
mt-Co1 -7257 -7632
mt-Co2 -7163 -6523
mt-Co3 -7307 -7023
mt-Cytb -6947 -7620
mt-Nd1 -7119 -7489
mt-Nd2 -7271 -7495
mt-Nd3 -6642 -5922
mt-Nd4 -6682 -7382
mt-Nd4l -3936 -7494
mt-Nd5 -6386 -7564
mt-Nd6 -6677 -7251
Prorp 1087 -5691
Trmt10c -5141 -6714
Trnt1 238 -2405



Mitochondrial-translation-elongation

Mitochondrial-translation-elongation
metric value
setSize 88
pMANOVA 2.9e-41
p.adjustMANOVA 6.18e-39
s.dist 1.12
s.young -0.827
s.old -0.758
p.young 3.38e-41
p.old 8.11e-35




Top 20 genes
Gene young old
Mrpl30 -7337 -7761
Mrpl42 -7248 -7608
Ptcd3 -7230 -7612
Mrps35 -7210 -7615
Mrps17 -7178 -7576
Mrpl2 -7320 -7372
Mrps9 -6971 -7623
Mrpl45 -6896 -7603
Mrpl28 -6906 -7373
Tufm -6846 -7363
Mrpl9 -6996 -7202
Mrpl46 -6817 -7379
Mrpl51 -7056 -7044
Gfm1 -6643 -7457
Mrps31 -6624 -7462
Mrpl3 -6890 -7156
Mrps27 -6764 -7263
Mrpl1 -6750 -7265
Mrpl18 -6929 -7035
Mrpl14 -6990 -6964

Click HERE to show all gene set members

All member genes
young old
Aurkaip1 -6248 -5678
Chchd1 -5921 -5916
Dap3 -6390 -6628
Eral1 -5904 -6599
Gadd45gip1 -6867 -6703
Gfm1 -6643 -7457
Mrpl1 -6750 -7265
Mrpl10 -5595 -5933
Mrpl11 -5991 -5910
Mrpl12 -7029 -6604
Mrpl13 -5916 -6619
Mrpl14 -6990 -6964
Mrpl15 -6574 -6827
Mrpl16 -5878 -6598
Mrpl17 -5372 -4564
Mrpl18 -6929 -7035
Mrpl19 -6834 -6958
Mrpl2 -7320 -7372
Mrpl20 -5318 -4089
Mrpl21 -5591 -6947
Mrpl22 -5839 -6141
Mrpl23 -6924 -4943
Mrpl24 -5493 -4092
Mrpl27 -4868 -4867
Mrpl28 -6906 -7373
Mrpl3 -6890 -7156
Mrpl30 -7337 -7761
Mrpl32 -5449 -6000
Mrpl33 -676 3231
Mrpl34 -6559 -6570
Mrpl35 -6678 -7167
Mrpl36 -4714 -4959
Mrpl37 -6747 -7068
Mrpl38 -6844 -6174
Mrpl39 -6696 -7130
Mrpl4 -6884 -6566
Mrpl40 -3530 -4283
Mrpl41 -6758 -6786
Mrpl42 -7248 -7608
Mrpl43 -5164 -5466
Mrpl44 -6513 -6841
Mrpl45 -6896 -7603
Mrpl46 -6817 -7379
Mrpl47 -6690 -6931
Mrpl48 -4965 -2296
Mrpl49 -5909 -5838
Mrpl50 -6278 -7053
Mrpl51 -7056 -7044
Mrpl52 -994 253
Mrpl53 -6252 -4354
Mrpl54 -1065 -2562
Mrpl55 -7064 -6715
Mrpl57 -2056 -4071
Mrpl58 -6710 -6615
Mrpl9 -6996 -7202
Mrps10 -1566 1880
Mrps11 -5399 -5798
Mrps12 -4262 -4111
Mrps14 -6073 -6439
Mrps15 -6805 -6956
Mrps16 -6308 -6130
Mrps17 -7178 -7576
Mrps18a -6175 -6605
Mrps18b -5938 -4872
Mrps18c -5687 -6088
Mrps2 -6425 -7205
Mrps21 -6827 -7070
Mrps22 -5305 -6723
Mrps23 -6635 -5774
Mrps24 -6748 -6081
Mrps25 -6490 -6633
Mrps26 -5415 -3403
Mrps27 -6764 -7263
Mrps28 -6850 -6886
Mrps30 -6407 -6943
Mrps31 -6624 -7462
Mrps33 -6284 -6495
Mrps34 -6156 -4884
Mrps35 -7210 -7615
Mrps36 -6283 -6967
Mrps5 -6689 -6857
Mrps6 -4817 -1971
Mrps7 -6460 -6613
Mrps9 -6971 -7623
Oxa1l -7035 -6627
Ptcd3 -7230 -7612
Tsfm -6347 -6440
Tufm -6846 -7363



Mitochondrial-translation

Mitochondrial-translation
metric value
setSize 94
pMANOVA 6.95e-44
p.adjustMANOVA 1.78e-41
s.dist 1.12
s.young -0.825
s.old -0.758
p.young 1.11e-43
p.old 4.24e-37




Top 20 genes
Gene young old
Mrpl30 -7337 -7761
Mrpl42 -7248 -7608
Ptcd3 -7230 -7612
Mrps35 -7210 -7615
Mrps17 -7178 -7576
Mrpl2 -7320 -7372
Mrps9 -6971 -7623
Mrpl45 -6896 -7603
Mrpl28 -6906 -7373
Tufm -6846 -7363
Mrpl9 -6996 -7202
Mrpl46 -6817 -7379
Mrpl51 -7056 -7044
Mtif2 -6744 -7351
Gfm1 -6643 -7457
Mrps31 -6624 -7462
Mrpl3 -6890 -7156
Mrps27 -6764 -7263
Mrpl1 -6750 -7265
Gfm2 -6544 -7469

Click HERE to show all gene set members

All member genes
young old
Aurkaip1 -6248 -5678
Chchd1 -5921 -5916
Dap3 -6390 -6628
Eral1 -5904 -6599
Gadd45gip1 -6867 -6703
Gfm1 -6643 -7457
Gfm2 -6544 -7469
Mrpl1 -6750 -7265
Mrpl10 -5595 -5933
Mrpl11 -5991 -5910
Mrpl12 -7029 -6604
Mrpl13 -5916 -6619
Mrpl14 -6990 -6964
Mrpl15 -6574 -6827
Mrpl16 -5878 -6598
Mrpl17 -5372 -4564
Mrpl18 -6929 -7035
Mrpl19 -6834 -6958
Mrpl2 -7320 -7372
Mrpl20 -5318 -4089
Mrpl21 -5591 -6947
Mrpl22 -5839 -6141
Mrpl23 -6924 -4943
Mrpl24 -5493 -4092
Mrpl27 -4868 -4867
Mrpl28 -6906 -7373
Mrpl3 -6890 -7156
Mrpl30 -7337 -7761
Mrpl32 -5449 -6000
Mrpl33 -676 3231
Mrpl34 -6559 -6570
Mrpl35 -6678 -7167
Mrpl36 -4714 -4959
Mrpl37 -6747 -7068
Mrpl38 -6844 -6174
Mrpl39 -6696 -7130
Mrpl4 -6884 -6566
Mrpl40 -3530 -4283
Mrpl41 -6758 -6786
Mrpl42 -7248 -7608
Mrpl43 -5164 -5466
Mrpl44 -6513 -6841
Mrpl45 -6896 -7603
Mrpl46 -6817 -7379
Mrpl47 -6690 -6931
Mrpl48 -4965 -2296
Mrpl49 -5909 -5838
Mrpl50 -6278 -7053
Mrpl51 -7056 -7044
Mrpl52 -994 253
Mrpl53 -6252 -4354
Mrpl54 -1065 -2562
Mrpl55 -7064 -6715
Mrpl57 -2056 -4071
Mrpl58 -6710 -6615
Mrpl9 -6996 -7202
Mrps10 -1566 1880
Mrps11 -5399 -5798
Mrps12 -4262 -4111
Mrps14 -6073 -6439
Mrps15 -6805 -6956
Mrps16 -6308 -6130
Mrps17 -7178 -7576
Mrps18a -6175 -6605
Mrps18b -5938 -4872
Mrps18c -5687 -6088
Mrps2 -6425 -7205
Mrps21 -6827 -7070
Mrps22 -5305 -6723
Mrps23 -6635 -5774
Mrps24 -6748 -6081
Mrps25 -6490 -6633
Mrps26 -5415 -3403
Mrps27 -6764 -7263
Mrps28 -6850 -6886
Mrps30 -6407 -6943
Mrps31 -6624 -7462
Mrps33 -6284 -6495
Mrps34 -6156 -4884
Mrps35 -7210 -7615
Mrps36 -6283 -6967
Mrps5 -6689 -6857
Mrps6 -4817 -1971
Mrps7 -6460 -6613
Mrps9 -6971 -7623
Mrrf -6453 -6787
Mtfmt -3436 -3006
Mtif2 -6744 -7351
Mtif3 -5780 -5500
Mtrf1l -5597 -5796
Oxa1l -7035 -6627
Ptcd3 -7230 -7612
Tsfm -6347 -6440
Tufm -6846 -7363



Mitochondrial-translation-termination

Mitochondrial-translation-termination
metric value
setSize 88
pMANOVA 4.51e-41
p.adjustMANOVA 8.23e-39
s.dist 1.12
s.young -0.825
s.old -0.756
p.young 5.15e-41
p.old 1.18e-34




Top 20 genes
Gene young old
Mrpl30 -7337 -7761
Mrpl42 -7248 -7608
Ptcd3 -7230 -7612
Mrps35 -7210 -7615
Mrps17 -7178 -7576
Mrpl2 -7320 -7372
Mrps9 -6971 -7623
Mrpl45 -6896 -7603
Mrpl28 -6906 -7373
Mrpl9 -6996 -7202
Mrpl46 -6817 -7379
Mrpl51 -7056 -7044
Mrps31 -6624 -7462
Mrpl3 -6890 -7156
Mrps27 -6764 -7263
Mrpl1 -6750 -7265
Gfm2 -6544 -7469
Mrpl18 -6929 -7035
Mrpl14 -6990 -6964
Mrps21 -6827 -7070

Click HERE to show all gene set members

All member genes
young old
Aurkaip1 -6248 -5678
Chchd1 -5921 -5916
Dap3 -6390 -6628
Eral1 -5904 -6599
Gadd45gip1 -6867 -6703
Gfm2 -6544 -7469
Mrpl1 -6750 -7265
Mrpl10 -5595 -5933
Mrpl11 -5991 -5910
Mrpl12 -7029 -6604
Mrpl13 -5916 -6619
Mrpl14 -6990 -6964
Mrpl15 -6574 -6827
Mrpl16 -5878 -6598
Mrpl17 -5372 -4564
Mrpl18 -6929 -7035
Mrpl19 -6834 -6958
Mrpl2 -7320 -7372
Mrpl20 -5318 -4089
Mrpl21 -5591 -6947
Mrpl22 -5839 -6141
Mrpl23 -6924 -4943
Mrpl24 -5493 -4092
Mrpl27 -4868 -4867
Mrpl28 -6906 -7373
Mrpl3 -6890 -7156
Mrpl30 -7337 -7761
Mrpl32 -5449 -6000
Mrpl33 -676 3231
Mrpl34 -6559 -6570
Mrpl35 -6678 -7167
Mrpl36 -4714 -4959
Mrpl37 -6747 -7068
Mrpl38 -6844 -6174
Mrpl39 -6696 -7130
Mrpl4 -6884 -6566
Mrpl40 -3530 -4283
Mrpl41 -6758 -6786
Mrpl42 -7248 -7608
Mrpl43 -5164 -5466
Mrpl44 -6513 -6841
Mrpl45 -6896 -7603
Mrpl46 -6817 -7379
Mrpl47 -6690 -6931
Mrpl48 -4965 -2296
Mrpl49 -5909 -5838
Mrpl50 -6278 -7053
Mrpl51 -7056 -7044
Mrpl52 -994 253
Mrpl53 -6252 -4354
Mrpl54 -1065 -2562
Mrpl55 -7064 -6715
Mrpl57 -2056 -4071
Mrpl58 -6710 -6615
Mrpl9 -6996 -7202
Mrps10 -1566 1880
Mrps11 -5399 -5798
Mrps12 -4262 -4111
Mrps14 -6073 -6439
Mrps15 -6805 -6956
Mrps16 -6308 -6130
Mrps17 -7178 -7576
Mrps18a -6175 -6605
Mrps18b -5938 -4872
Mrps18c -5687 -6088
Mrps2 -6425 -7205
Mrps21 -6827 -7070
Mrps22 -5305 -6723
Mrps23 -6635 -5774
Mrps24 -6748 -6081
Mrps25 -6490 -6633
Mrps26 -5415 -3403
Mrps27 -6764 -7263
Mrps28 -6850 -6886
Mrps30 -6407 -6943
Mrps31 -6624 -7462
Mrps33 -6284 -6495
Mrps34 -6156 -4884
Mrps35 -7210 -7615
Mrps36 -6283 -6967
Mrps5 -6689 -6857
Mrps6 -4817 -1971
Mrps7 -6460 -6613
Mrps9 -6971 -7623
Mrrf -6453 -6787
Mtrf1l -5597 -5796
Oxa1l -7035 -6627
Ptcd3 -7230 -7612



Mitochondrial-translation-initiation

Mitochondrial-translation-initiation
metric value
setSize 88
pMANOVA 1.35e-40
p.adjustMANOVA 2.16e-38
s.dist 1.11
s.young -0.821
s.old -0.75
p.young 1.25e-40
p.old 4.3e-34




Top 20 genes
Gene young old
Mrpl30 -7337 -7761
Mrpl42 -7248 -7608
Ptcd3 -7230 -7612
Mrps35 -7210 -7615
Mrps17 -7178 -7576
Mrpl2 -7320 -7372
Mrps9 -6971 -7623
Mrpl45 -6896 -7603
Mrpl28 -6906 -7373
Mrpl9 -6996 -7202
Mrpl46 -6817 -7379
Mrpl51 -7056 -7044
Mtif2 -6744 -7351
Mrps31 -6624 -7462
Mrpl3 -6890 -7156
Mrps27 -6764 -7263
Mrpl1 -6750 -7265
Mrpl18 -6929 -7035
Mrpl14 -6990 -6964
Mrps21 -6827 -7070

Click HERE to show all gene set members

All member genes
young old
Aurkaip1 -6248 -5678
Chchd1 -5921 -5916
Dap3 -6390 -6628
Eral1 -5904 -6599
Gadd45gip1 -6867 -6703
Mrpl1 -6750 -7265
Mrpl10 -5595 -5933
Mrpl11 -5991 -5910
Mrpl12 -7029 -6604
Mrpl13 -5916 -6619
Mrpl14 -6990 -6964
Mrpl15 -6574 -6827
Mrpl16 -5878 -6598
Mrpl17 -5372 -4564
Mrpl18 -6929 -7035
Mrpl19 -6834 -6958
Mrpl2 -7320 -7372
Mrpl20 -5318 -4089
Mrpl21 -5591 -6947
Mrpl22 -5839 -6141
Mrpl23 -6924 -4943
Mrpl24 -5493 -4092
Mrpl27 -4868 -4867
Mrpl28 -6906 -7373
Mrpl3 -6890 -7156
Mrpl30 -7337 -7761
Mrpl32 -5449 -6000
Mrpl33 -676 3231
Mrpl34 -6559 -6570
Mrpl35 -6678 -7167
Mrpl36 -4714 -4959
Mrpl37 -6747 -7068
Mrpl38 -6844 -6174
Mrpl39 -6696 -7130
Mrpl4 -6884 -6566
Mrpl40 -3530 -4283
Mrpl41 -6758 -6786
Mrpl42 -7248 -7608
Mrpl43 -5164 -5466
Mrpl44 -6513 -6841
Mrpl45 -6896 -7603
Mrpl46 -6817 -7379
Mrpl47 -6690 -6931
Mrpl48 -4965 -2296
Mrpl49 -5909 -5838
Mrpl50 -6278 -7053
Mrpl51 -7056 -7044
Mrpl52 -994 253
Mrpl53 -6252 -4354
Mrpl54 -1065 -2562
Mrpl55 -7064 -6715
Mrpl57 -2056 -4071
Mrpl58 -6710 -6615
Mrpl9 -6996 -7202
Mrps10 -1566 1880
Mrps11 -5399 -5798
Mrps12 -4262 -4111
Mrps14 -6073 -6439
Mrps15 -6805 -6956
Mrps16 -6308 -6130
Mrps17 -7178 -7576
Mrps18a -6175 -6605
Mrps18b -5938 -4872
Mrps18c -5687 -6088
Mrps2 -6425 -7205
Mrps21 -6827 -7070
Mrps22 -5305 -6723
Mrps23 -6635 -5774
Mrps24 -6748 -6081
Mrps25 -6490 -6633
Mrps26 -5415 -3403
Mrps27 -6764 -7263
Mrps28 -6850 -6886
Mrps30 -6407 -6943
Mrps31 -6624 -7462
Mrps33 -6284 -6495
Mrps34 -6156 -4884
Mrps35 -7210 -7615
Mrps36 -6283 -6967
Mrps5 -6689 -6857
Mrps6 -4817 -1971
Mrps7 -6460 -6613
Mrps9 -6971 -7623
Mtfmt -3436 -3006
Mtif2 -6744 -7351
Mtif3 -5780 -5500
Oxa1l -7035 -6627
Ptcd3 -7230 -7612



Mitochondrial-iron-sulfur-cluster-biogenesis

Mitochondrial-iron-sulfur-cluster-biogenesis
metric value
setSize 10
pMANOVA 6.99e-05
p.adjustMANOVA 0.000935
s.dist 1.07
s.young -0.741
s.old -0.775
p.young 4.95e-05
p.old 2.19e-05




Top 20 genes
Gene young old
Nfs1 -7331 -7674
Isca1 -7123 -7445
Isca2 -6619 -6949
Fdx1 -6618 -6735
Fxn -6784 -6569
Iscu -5913 -6379
Glrx5 -6203 -4666
Slc25a37 -2322 -5900
Slc25a28 -3690 -3434
Hscb -1609 -5700

Click HERE to show all gene set members

All member genes
young old
Fdx1 -6618 -6735
Fxn -6784 -6569
Glrx5 -6203 -4666
Hscb -1609 -5700
Isca1 -7123 -7445
Isca2 -6619 -6949
Iscu -5913 -6379
Nfs1 -7331 -7674
Slc25a28 -3690 -3434
Slc25a37 -2322 -5900



Glyoxylate-metabolism-and-glycine-degradation

Glyoxylate-metabolism-and-glycine-degradation
metric value
setSize 25
pMANOVA 7.78e-11
p.adjustMANOVA 3.12e-09
s.dist 1.06
s.young -0.751
s.old -0.748
p.young 7.74e-11
p.old 9.53e-11




Top 20 genes
Gene young old
Bckdha -7342 -7803
Dld -7216 -7696
Dlst -7165 -7693
Pdhx -7172 -7679
Ndufab1 -7247 -7579
Pxmp2 -6949 -7658
Aldh4a1 -7153 -7436
Bckdhb -6907 -7611
Pdhb -7169 -7319
Ogdh -7013 -7475
Pdha1 -7106 -7283
Dlat -7003 -7332
Dbt -6615 -7756
Got2 -6849 -6590
Lias -6337 -6370
Gcsh -4256 -7388
Ddo -5929 -5213
Dhtkd1 -4047 -5919
Lipt2 -3800 -5935
Gnmt -3686 -5324

Click HERE to show all gene set members

All member genes
young old
Aldh4a1 -7153 -7436
Amt -5168 1070
Bckdha -7342 -7803
Bckdhb -6907 -7611
Dbt -6615 -7756
Ddo -5929 -5213
Dhtkd1 -4047 -5919
Dlat -7003 -7332
Dld -7216 -7696
Dlst -7165 -7693
Gcsh -4256 -7388
Gldc -2462 1585
Gnmt -3686 -5324
Got2 -6849 -6590
Grhpr 1747 -5672
Hoga1 -1971 695
Lias -6337 -6370
Lipt1 -2499 -5036
Lipt2 -3800 -5935
Ndufab1 -7247 -7579
Ogdh -7013 -7475
Pdha1 -7106 -7283
Pdhb -7169 -7319
Pdhx -7172 -7679
Pxmp2 -6949 -7658



Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle

Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle
metric value
setSize 51
pMANOVA 4.48e-21
p.adjustMANOVA 4.1e-19
s.dist 1.05
s.young -0.725
s.old -0.76
p.young 3.15e-19
p.old 5.37e-21




Top 20 genes
Gene young old
Adhfe1 -7349 -7821
Ldhb -7348 -7811
Sdha -7346 -7813
Sdhd -7333 -7791
Sucla2 -7292 -7689
Mpc2 -7294 -7670
Suclg2 -7193 -7724
Idh3b -7322 -7586
Dld -7216 -7696
Suclg1 -7259 -7645
Dlst -7165 -7693
Pdhx -7172 -7679
Cs -7238 -7580
Sdhb -7295 -7485
Idh3a -7085 -7634
Nnt -6917 -7798
D2hgdh -7104 -7565
Sdhc -7227 -7405
Me3 -7147 -7472
Fahd1 -7052 -7556

Click HERE to show all gene set members

All member genes
young old
Aco2 -6436 -6977
Adhfe1 -7349 -7821
Bsg -6548 -7267
Cs -7238 -7580
D2hgdh -7104 -7565
Dlat -7003 -7332
Dld -7216 -7696
Dlst -7165 -7693
Fahd1 -7052 -7556
Fh1 -7115 -7449
Glo1 -5689 -5454
Gstz1 -6066 -6846
Hagh 3129 -1329
Idh2 -6961 -7381
Idh3a -7085 -7634
Idh3b -7322 -7586
Idh3g -7228 -7314
L2hgdh -6879 -7484
Ldha 3559 -4312
Ldhb -7348 -7811
Mdh2 -7233 -7179
Me1 -6765 -6942
Me2 5856 4582
Me3 -7147 -7472
Mpc1 -7043 -7036
Mpc2 -7294 -7670
Nnt -6917 -7798
Ogdh -7013 -7475
Pdha1 -7106 -7283
Pdhb -7169 -7319
Pdhx -7172 -7679
Pdk1 4156 -6364
Pdk2 -6889 -7055
Pdk3 6805 6440
Pdk4 -1655 1645
Pdp1 -4181 -5275
Pdp2 -5917 -7570
Pdpr -5996 -7506
Ppard -5588 -4490
Rxra -6194 -6804
Sdha -7346 -7813
Sdhb -7295 -7485
Sdhc -7227 -7405
Sdhd -7333 -7791
Slc16a1 -5936 -4200
Slc16a3 7305 6044
Slc16a8 -4482 -3791
Sucla2 -7292 -7689
Suclg1 -7259 -7645
Suclg2 -7193 -7724
Vdac1 -7008 -7195



Collagen-chain-trimerization

Collagen-chain-trimerization
metric value
setSize 33
pMANOVA 1.12e-13
p.adjustMANOVA 7.15e-12
s.dist 1.04
s.young 0.737
s.old 0.74
p.young 2.34e-13
p.old 1.79e-13




Top 20 genes
Gene young old
Col8a2 7452 6978
Col8a1 7519 6875
Col5a2 7480 6907
Col12a1 7235 7031
Col16a1 7349 6856
Col1a2 7362 6786
Col14a1 7303 6796
Col4a3 7037 6967
Col11a1 7093 6902
Col27a1 7356 6638
Col4a5 7202 6747
Col4a4 7049 6807
Col1a1 7237 6629
Col9a2 7498 6397
Col6a1 7176 6438
Col5a1 7233 6290
Col6a2 6971 6524
Col15a1 6814 6634
Col3a1 6563 6455
Col26a1 7193 5097

Click HERE to show all gene set members

All member genes
young old
Col11a1 7093 6902
Col11a2 -1021 3528
Col12a1 7235 7031
Col13a1 2636 3872
Col14a1 7303 6796
Col15a1 6814 6634
Col16a1 7349 6856
Col18a1 6116 5391
Col1a1 7237 6629
Col1a2 7362 6786
Col20a1 2825 6268
Col23a1 5725 2177
Col25a1 -1076 474
Col26a1 7193 5097
Col27a1 7356 6638
Col28a1 215 3053
Col3a1 6563 6455
Col4a1 5635 5181
Col4a2 5963 4644
Col4a3 7037 6967
Col4a4 7049 6807
Col4a5 7202 6747
Col4a6 2683 4540
Col5a1 7233 6290
Col5a2 7480 6907
Col5a3 2225 -2736
Col6a1 7176 6438
Col6a2 6971 6524
Col6a3 5781 6084
Col6a6 1479 -6594
Col8a1 7519 6875
Col8a2 7452 6978
Col9a2 7498 6397



Mitochondrial-tRNA-aminoacylation

Mitochondrial-tRNA-aminoacylation
metric value
setSize 19
pMANOVA 3.66e-08
p.adjustMANOVA 1.06e-06
s.dist 1.04
s.young -0.756
s.old -0.712
p.young 1.14e-08
p.old 7.59e-08




Top 20 genes
Gene young old
Fars2 -6885 -7333
Sars2 -6953 -6965
Nars2 -6694 -7073
Ppa2 -6676 -6918
Vars2 -6968 -6459
Cars2 -6673 -6550
Yars2 -6001 -7155
Iars2 -5691 -7099
Aars2 -6224 -6392
Hars2 -5875 -6761
Dars2 -5581 -7062
Tars2 -6442 -5956
Mars2 -5106 -7011
Rars2 -5676 -5759
Wars2 -4658 -5948
Pars2 -3576 -3342
Ears2 -1578 -3330
Lars2 -6814 -414
Kars -1031 -313

Click HERE to show all gene set members

All member genes
young old
Aars2 -6224 -6392
Cars2 -6673 -6550
Dars2 -5581 -7062
Ears2 -1578 -3330
Fars2 -6885 -7333
Hars2 -5875 -6761
Iars2 -5691 -7099
Kars -1031 -313
Lars2 -6814 -414
Mars2 -5106 -7011
Nars2 -6694 -7073
Pars2 -3576 -3342
Ppa2 -6676 -6918
Rars2 -5676 -5759
Sars2 -6953 -6965
Tars2 -6442 -5956
Vars2 -6968 -6459
Wars2 -4658 -5948
Yars2 -6001 -7155



Mitochondrial-protein-import

Mitochondrial-protein-import
metric value
setSize 57
pMANOVA 8.67e-23
p.adjustMANOVA 8.53e-21
s.dist 1.03
s.young -0.762
s.old -0.686
p.young 2.29e-23
p.old 2.95e-19




Top 20 genes
Gene young old
Ndufb8 -7343 -7800
Timm23 -7335 -7749
Cs -7238 -7580
Atp5a1 -7220 -7504
Hspa9 -7037 -7692
Hspd1 -6966 -7697
Grpel1 -7078 -7473
Idh3g -7228 -7314
Atp5b -7224 -7258
Cyc1 -7237 -7220
Slc25a4 -7089 -7295
Coq2 -7039 -7275
Ldhd -6770 -7536
Chchd3 -7066 -7212
Vdac1 -7008 -7195
Slc25a12 -7001 -7181
Timm44 -7154 -7015
Cmc2 -6667 -7225
Samm50 -7217 -6662
Pmpca -6712 -7102

Click HERE to show all gene set members

All member genes
young old
Aco2 -6436 -6977
Atp5a1 -7220 -7504
Atp5b -7224 -7258
Bcs1l -5832 -6564
Chchd10 -7262 -6494
Chchd2 -7180 -5992
Chchd3 -7066 -7212
Chchd5 -1580 -3461
Chchd7 -6825 -6448
Cmc2 -6667 -7225
Cmc4 -3869 1658
Coa4 -1599 348
Coa6 -4801 -4707
Coq2 -7039 -7275
Cox19 6674 6213
Cs -7238 -7580
Cyc1 -7237 -7220
Fxn -6784 -6569
Gfer -1953 -4416
Gm45799 -1631 4287
Grpel1 -7078 -7473
Grpel2 -4955 -6528
Hscb -1609 -5700
Hspa9 -7037 -7692
Hspd1 -6966 -7697
Idh3g -7228 -7314
Ldhd -6770 -7536
Mtx1 -5805 -4557
Mtx2 -6403 -6945
Ndufb8 -7343 -7800
Pam16 -5409 -4217
Pitrm1 -5821 -6104
Pmpca -6712 -7102
Pmpcb -5714 -7243
Samm50 -7217 -6662
Slc25a12 -7001 -7181
Slc25a13 -5896 -6938
Slc25a4 -7089 -7295
Taz -5545 -5487
Timm10 -5933 -5648
Timm13 -5069 -2877
Timm17a -6452 -6120
Timm17b -2372 -4104
Timm21 -6376 -7056
Timm22 -3823 -5072
Timm23 -7335 -7749
Timm44 -7154 -7015
Timm50 -6322 -5800
Timm8b -6609 -6897
Timm9 -5723 -5076
Tomm20 -4097 -410
Tomm22 -5748 -5300
Tomm40 -6658 -5282
Tomm6 -3900 -1449
Tomm7 -4071 -4401
Tomm70a -5828 -6506
Vdac1 -7008 -7195



Metabolism-of-cofactors

Metabolism-of-cofactors
metric value
setSize 18
pMANOVA 6.03e-07
p.adjustMANOVA 1.4e-05
s.dist 0.979
s.young -0.703
s.old -0.681
p.young 2.41e-07
p.old 5.56e-07




Top 20 genes
Gene young old
Coq5 -7232 -7551
Coq9 -7305 -7450
Coq6 -7111 -7345
Coq3 -6915 -7413
Coq2 -7039 -7275
Pdss2 -6819 -7474
Pdss1 -6299 -6919
Coq7 -6572 -6603
Akt1 -6210 -5765
Gchfr -5040 -6739
Pts -5872 -4675
Calm1 -4595 -4970
Idh1 -3318 -6643
Spr -5793 -3582
Nos3 -4231 -4860

Click HERE to show all gene set members

All member genes
young old
Akt1 -6210 -5765
Calm1 -4595 -4970
Coq2 -7039 -7275
Coq3 -6915 -7413
Coq5 -7232 -7551
Coq6 -7111 -7345
Coq7 -6572 -6603
Coq9 -7305 -7450
Dhfr 3475 -3357
Gch1 -5671 58
Gchfr -5040 -6739
Idh1 -3318 -6643
Nos3 -4231 -4860
Pdss1 -6299 -6919
Pdss2 -6819 -7474
Prkg2 108 528
Pts -5872 -4675
Spr -5793 -3582



Keratan-sulfate-degradation

Keratan-sulfate-degradation
metric value
setSize 10
pMANOVA 0.000699
p.adjustMANOVA 0.00596
s.dist 0.932
s.young 0.68
s.old 0.638
p.young 0.000195
p.old 0.00048




Top 20 genes
Gene young old
Hexa 7315 6493
Lum 7163 6376
Fmod 6247 6867
Omd 6306 6521
Prelp 6330 6402
Ogn 6618 4809
Hexb 5022 5616
Glb1l 5086 5055
Glb1 5822 1047

Click HERE to show all gene set members

All member genes
young old
Fmod 6247 6867
Glb1 5822 1047
Glb1l 5086 5055
Gns -4478 -5630
Hexa 7315 6493
Hexb 5022 5616
Lum 7163 6376
Ogn 6618 4809
Omd 6306 6521
Prelp 6330 6402



CS/DS-degradation

CS/DS-degradation
metric value
setSize 11
pMANOVA 0.000322
p.adjustMANOVA 0.00317
s.dist 0.928
s.young 0.62
s.old 0.691
p.young 0.000374
p.old 7.28e-05




Top 20 genes
Gene young old
Bgn 7481 6830
Cspg4 7500 6779
Dcn 7414 6701
Vcan 7188 6694
Hexa 7315 6493
Arsb 6684 5613
Ids 6784 4640
Hexb 5022 5616
Hyal1 4392 6096

Click HERE to show all gene set members

All member genes
young old
Arsb 6684 5613
Bgn 7481 6830
Cspg4 7500 6779
Cspg5 -3048 1942
Dcn 7414 6701
Hexa 7315 6493
Hexb 5022 5616
Hyal1 4392 6096
Ids 6784 4640
Idua -5121 -5157
Vcan 7188 6694



Collagen-biosynthesis-and-modifying-enzymes

Collagen-biosynthesis-and-modifying-enzymes
metric value
setSize 56
pMANOVA 1.44e-17
p.adjustMANOVA 1.15e-15
s.dist 0.914
s.young 0.637
s.old 0.655
p.young 1.59e-16
p.old 2.1e-17




Top 20 genes
Gene young old
Col8a2 7452 6978
P3h2 7374 7030
Col8a1 7519 6875
Col5a2 7480 6907
Col12a1 7235 7031
Col16a1 7349 6856
Col1a2 7362 6786
Col14a1 7303 6796
Col4a3 7037 6967
Col11a1 7093 6902
Col27a1 7356 6638
Adamts2 7469 6535
Col4a5 7202 6747
Pcolce 7373 6528
Col4a4 7049 6807
Col1a1 7237 6629
Col9a2 7498 6397
P3h3 7230 6562
Col6a1 7176 6438
Col5a1 7233 6290

Click HERE to show all gene set members

All member genes
young old
Adamts14 3117 5979
Adamts2 7469 6535
Adamts3 -4916 -4222
Bmp1 7236 6255
Col11a1 7093 6902
Col11a2 -1021 3528
Col12a1 7235 7031
Col13a1 2636 3872
Col14a1 7303 6796
Col15a1 6814 6634
Col16a1 7349 6856
Col18a1 6116 5391
Col1a1 7237 6629
Col1a2 7362 6786
Col20a1 2825 6268
Col23a1 5725 2177
Col25a1 -1076 474
Col26a1 7193 5097
Col27a1 7356 6638
Col28a1 215 3053
Col3a1 6563 6455
Col4a1 5635 5181
Col4a2 5963 4644
Col4a3 7037 6967
Col4a4 7049 6807
Col4a5 7202 6747
Col4a6 2683 4540
Col5a1 7233 6290
Col5a2 7480 6907
Col5a3 2225 -2736
Col6a1 7176 6438
Col6a2 6971 6524
Col6a3 5781 6084
Col6a6 1479 -6594
Col8a1 7519 6875
Col8a2 7452 6978
Col9a2 7498 6397
Colgalt1 4060 2838
Colgalt2 -4035 -2084
Crtap 6718 3923
P3h1 6856 4702
P3h2 7374 7030
P3h3 7230 6562
P4ha1 4494 6389
P4ha2 -5915 -3841
P4ha3 6223 4289
P4hb 6441 4378
Pcolce 7373 6528
Pcolce2 3514 6586
Plod1 -2323 2388
Plod2 7080 6224
Plod3 5833 4938
Ppib 5989 3349
Serpinh1 1466 3868
Tll1 5403 4589
Tll2 -784 -5372



Regulation-of-pyruvate-dehydrogenase-(PDH)-complex

Regulation-of-pyruvate-dehydrogenase-(PDH)-complex
metric value
setSize 15
pMANOVA 2.55e-05
p.adjustMANOVA 0.000424
s.dist 0.914
s.young -0.615
s.old -0.676
p.young 3.77e-05
p.old 5.76e-06




Top 20 genes
Gene young old
Dld -7216 -7696
Pdhx -7172 -7679
Pdhb -7169 -7319
Pdha1 -7106 -7283
Dlat -7003 -7332
Pdk2 -6889 -7055
Pdpr -5996 -7506
Pdp2 -5917 -7570
Rxra -6194 -6804
Gstz1 -6066 -6846
Ppard -5588 -4490
Pdp1 -4181 -5275

Click HERE to show all gene set members

All member genes
young old
Dlat -7003 -7332
Dld -7216 -7696
Gstz1 -6066 -6846
Pdha1 -7106 -7283
Pdhb -7169 -7319
Pdhx -7172 -7679
Pdk1 4156 -6364
Pdk2 -6889 -7055
Pdk3 6805 6440
Pdk4 -1655 1645
Pdp1 -4181 -5275
Pdp2 -5917 -7570
Pdpr -5996 -7506
Ppard -5588 -4490
Rxra -6194 -6804



Crosslinking-of-collagen-fibrils

Crosslinking-of-collagen-fibrils
metric value
setSize 10
pMANOVA 0.000872
p.adjustMANOVA 0.00729
s.dist 0.887
s.young 0.685
s.old 0.563
p.young 0.000175
p.old 0.00206




Top 20 genes
Gene young old
Loxl2 7336 6852
Loxl3 7361 6821
Pcolce 7373 6528
Lox 7364 6358
Bmp1 7236 6255
Loxl1 7313 5950
Loxl4 6831 6223
Tll1 5403 4589

Click HERE to show all gene set members

All member genes
young old
Bmp1 7236 6255
Lox 7364 6358
Loxl1 7313 5950
Loxl2 7336 6852
Loxl3 7361 6821
Loxl4 6831 6223
Pcolce 7373 6528
Pxdn -3621 -6204
Tll1 5403 4589
Tll2 -784 -5372



ECM-proteoglycans

ECM-proteoglycans
metric value
setSize 43
pMANOVA 3.42e-13
p.adjustMANOVA 1.9e-11
s.dist 0.886
s.young 0.661
s.old 0.59
p.young 6.2e-14
p.old 2.23e-11




Top 20 genes
Gene young old
Ncam1 7473 7015
Tgfb2 7427 6986
Bgn 7481 6830
Tgfb3 7433 6863
Aspn 7430 6781
Dcn 7414 6701
Lama2 7478 6628
Itgav 7314 6700
Vcan 7188 6694
Col9a2 7498 6397
Serpine1 7216 6353
Lum 7163 6376
Lamc1 7347 5936
Itgb5 7035 6117
Fmod 6247 6867
Itgb3 7496 5721
Sparc 6776 6134
Itga9 6082 6594
Itgb1 6770 5825
Tgfb1 6984 5531

Click HERE to show all gene set members

All member genes
young old
Agrn -247 199
Aspn 7430 6781
Bgn 7481 6830
Col9a2 7498 6397
Comp 4501 6797
Dag1 3395 1176
Dcn 7414 6701
Fmod 6247 6867
Hapln1 -1235 1714
Hspg2 6535 3769
Itga2 3765 6228
Itga2b 5803 437
Itga7 6140 5835
Itga8 3673 5405
Itga9 6082 6594
Itgav 7314 6700
Itgax 1846 526
Itgb1 6770 5825
Itgb3 7496 5721
Itgb5 7035 6117
Itgb6 -4680 -6503
Lama2 7478 6628
Lama3 1858 -436
Lama4 3147 2662
Lama5 5048 -4782
Lamb1 6771 -983
Lamb2 2375 4485
Lamc1 7347 5936
Lrp4 2160 909
Lum 7163 6376
Matn4 4806 5530
Ncam1 7473 7015
Ptprs 6547 183
Serpine1 7216 6353
Sparc 6776 6134
Tgfb1 6984 5531
Tgfb2 7427 6986
Tgfb3 7433 6863
Tnc 4757 6330
Tnr 4918 5633
Tnxb 6557 4769
Vcan 7188 6694
Vtn -7117 -7433



tRNA-Aminoacylation

tRNA-Aminoacylation
metric value
setSize 26
pMANOVA 4.87e-08
p.adjustMANOVA 1.35e-06
s.dist 0.87
s.young -0.652
s.old -0.576
p.young 8.49e-09
p.old 3.7e-07




Top 20 genes
Gene young old
Fars2 -6885 -7333
Sars2 -6953 -6965
Nars2 -6694 -7073
Ppa2 -6676 -6918
Vars2 -6968 -6459
Cars2 -6673 -6550
Yars2 -6001 -7155
Iars2 -5691 -7099
Aars2 -6224 -6392
Hars2 -5875 -6761
Dars2 -5581 -7062
Tars2 -6442 -5956
Mars2 -5106 -7011
Rars2 -5676 -5759
Farsb -5407 -5600
Wars2 -4658 -5948
Ppa1 -3881 -5184
Pars2 -3576 -3342
Farsa -4086 -2900
Aimp1 -2872 -3408

Click HERE to show all gene set members

All member genes
young old
Aars2 -6224 -6392
Aimp1 -2872 -3408
Aimp2 -1669 2875
Cars2 -6673 -6550
Dars2 -5581 -7062
Ears2 -1578 -3330
Eef1e1 -4012 130
Fars2 -6885 -7333
Farsa -4086 -2900
Farsb -5407 -5600
Hars2 -5875 -6761
Iars2 -5691 -7099
Kars -1031 -313
Lars2 -6814 -414
Mars2 -5106 -7011
Nars2 -6694 -7073
Pars2 -3576 -3342
Ppa1 -3881 -5184
Ppa2 -6676 -6918
Rars2 -5676 -5759
Sars2 -6953 -6965
Tars 3361 754
Tars2 -6442 -5956
Vars2 -6968 -6459
Wars2 -4658 -5948
Yars2 -6001 -7155



Chondroitin-sulfate-biosynthesis

Chondroitin-sulfate-biosynthesis
metric value
setSize 16
pMANOVA 4.32e-05
p.adjustMANOVA 0.000635
s.dist 0.87
s.young 0.625
s.old 0.605
p.young 1.52e-05
p.old 2.75e-05




Top 20 genes
Gene young old
Bgn 7481 6830
Cspg4 7500 6779
Dcn 7414 6701
Vcan 7188 6694
Chpf2 6949 6362
Chpf 7328 5652
Chsy1 7110 5672
Chsy3 6387 6260
Chst3 6451 6127
Csgalnact2 6411 5972
Chst12 4324 4171
Chst11 1137 4315

Click HERE to show all gene set members

All member genes
young old
Bgn 7481 6830
Chpf 7328 5652
Chpf2 6949 6362
Chst11 1137 4315
Chst12 4324 4171
Chst15 -359 -4584
Chst3 6451 6127
Chst7 1335 -705
Chsy1 7110 5672
Chsy3 6387 6260
Csgalnact1 2042 -2352
Csgalnact2 6411 5972
Cspg4 7500 6779
Cspg5 -3048 1942
Dcn 7414 6701
Vcan 7188 6694



Triglyceride-catabolism

Triglyceride-catabolism
metric value
setSize 15
pMANOVA 9.29e-06
p.adjustMANOVA 0.000175
s.dist 0.868
s.young -0.503
s.old -0.708
p.young 0.000741
p.old 2.07e-06




Top 20 genes
Gene young old
Plin3 -6858 -7441
Cav1 -5892 -7143
Ppp1cb -6139 -5952
Prkaca -6075 -5990
Fabp3 -5416 -6575
Abhd5 -5259 -6321
Mgll -4506 -7118
Gpd2 -5217 -5433
Lipe -4226 -5925
Ppp1cc -3515 -5893
Fabp4 -2511 -7146
Ppp1ca -2389 -1250
Fabp5 -285 -5130
Plin1 -369 -3417

Click HERE to show all gene set members

All member genes
young old
Abhd5 -5259 -6321
Cav1 -5892 -7143
Fabp3 -5416 -6575
Fabp4 -2511 -7146
Fabp5 -285 -5130
Gpd2 -5217 -5433
Lipe -4226 -5925
Mgll -4506 -7118
Plin1 -369 -3417
Plin3 -6858 -7441
Ppp1ca -2389 -1250
Ppp1cb -6139 -5952
Ppp1cc -3515 -5893
Prkaca -6075 -5990
Prkacb 3875 -3919



Heme-biosynthesis

Heme-biosynthesis
metric value
setSize 12
pMANOVA 0.000539
p.adjustMANOVA 0.00476
s.dist 0.868
s.young -0.601
s.old -0.627
p.young 0.000312
p.old 0.00017




Top 20 genes
Gene young old
Cox10 -7063 -7211
Alad -6408 -7246
Alas1 -6613 -7012
Urod -6633 -6356
Fech -5630 -7325
Hmbs -6135 -6468
Cpox -4331 -6386
Uros -3819 -6314
Flvcr1 -1608 -2467
Alas2 -622 -3401
Ppox -1067 -1544

Click HERE to show all gene set members

All member genes
young old
Alad -6408 -7246
Alas1 -6613 -7012
Alas2 -622 -3401
Alb -2631 1215
Cox10 -7063 -7211
Cpox -4331 -6386
Fech -5630 -7325
Flvcr1 -1608 -2467
Hmbs -6135 -6468
Ppox -1067 -1544
Urod -6633 -6356
Uros -3819 -6314



Elastic-fibre-formation

Elastic-fibre-formation
metric value
setSize 38
pMANOVA 7.8e-11
p.adjustMANOVA 3.12e-09
s.dist 0.86
s.young 0.608
s.old 0.608
p.young 8.52e-11
p.old 8.68e-11




Top 20 genes
Gene young old
Tgfb2 7427 6986
Mfap5 7485 6861
Tgfb3 7433 6863
Loxl2 7336 6852
Loxl3 7361 6821
Ltbp3 7432 6685
Itga5 7309 6750
Itgav 7314 6700
Ltbp2 7174 6826
Lox 7364 6358
Mfap4 7221 6243
Fbln2 7256 6211
Bmp4 6772 6517
Loxl1 7313 5950
Ltbp4 7265 5969
Itgb5 7035 6117
Itgb3 7496 5721
Fbn1 6968 6107
Loxl4 6831 6223
Fbln5 6795 6253

Click HERE to show all gene set members

All member genes
young old
Bmp2 -2270 2145
Bmp4 6772 6517
Bmp7 -4799 -5293
Efemp1 -4901 -7119
Efemp2 6926 5475
Eln 5907 4689
Fbln1 -3620 3794
Fbln2 7256 6211
Fbln5 6795 6253
Fbn1 6968 6107
Fbn2 6918 5566
Furin 1738 -2954
Itga5 7309 6750
Itga8 3673 5405
Itgav 7314 6700
Itgb1 6770 5825
Itgb3 7496 5721
Itgb5 7035 6117
Itgb6 -4680 -6503
Itgb8 6492 6501
Lox 7364 6358
Loxl1 7313 5950
Loxl2 7336 6852
Loxl3 7361 6821
Loxl4 6831 6223
Ltbp1 2153 4810
Ltbp2 7174 6826
Ltbp3 7432 6685
Ltbp4 7265 5969
Mfap1b 2060 3988
Mfap2 7084 3420
Mfap3 919 -6
Mfap4 7221 6243
Mfap5 7485 6861
Tgfb1 6984 5531
Tgfb2 7427 6986
Tgfb3 7433 6863
Vtn -7117 -7433



Pyruvate-metabolism

Pyruvate-metabolism
metric value
setSize 27
pMANOVA 5.41e-08
p.adjustMANOVA 1.47e-06
s.dist 0.853
s.young -0.567
s.old -0.637
p.young 3.4e-07
p.old 9.95e-09




Top 20 genes
Gene young old
Ldhb -7348 -7811
Mpc2 -7294 -7670
Dld -7216 -7696
Pdhx -7172 -7679
Pdhb -7169 -7319
Pdha1 -7106 -7283
Dlat -7003 -7332
Vdac1 -7008 -7195
Mpc1 -7043 -7036
Pdk2 -6889 -7055
Bsg -6548 -7267
Me1 -6765 -6942
Pdpr -5996 -7506
Pdp2 -5917 -7570
Rxra -6194 -6804
Gstz1 -6066 -6846
Glo1 -5689 -5454
Ppard -5588 -4490
Slc16a1 -5936 -4200
Pdp1 -4181 -5275

Click HERE to show all gene set members

All member genes
young old
Bsg -6548 -7267
Dlat -7003 -7332
Dld -7216 -7696
Glo1 -5689 -5454
Gstz1 -6066 -6846
Hagh 3129 -1329
Ldha 3559 -4312
Ldhb -7348 -7811
Me1 -6765 -6942
Mpc1 -7043 -7036
Mpc2 -7294 -7670
Pdha1 -7106 -7283
Pdhb -7169 -7319
Pdhx -7172 -7679
Pdk1 4156 -6364
Pdk2 -6889 -7055
Pdk3 6805 6440
Pdk4 -1655 1645
Pdp1 -4181 -5275
Pdp2 -5917 -7570
Pdpr -5996 -7506
Ppard -5588 -4490
Rxra -6194 -6804
Slc16a1 -5936 -4200
Slc16a3 7305 6044
Slc16a8 -4482 -3791
Vdac1 -7008 -7195



Defects-in-cobalamin-(B12)-metabolism

Defects-in-cobalamin-(B12)-metabolism
metric value
setSize 12
pMANOVA 0.0011
p.adjustMANOVA 0.00865
s.dist 0.823
s.young -0.562
s.old -0.602
p.young 0.000753
p.old 0.000304




Top 20 genes
Gene young old
Mmut -7065 -7739
Mmachc -6958 -7440
Mtr -6792 -7533
Mmadhc -6728 -7010
Mmab -6646 -6987
Mmaa -6691 -6758
Cd320 -4968 -5750
Tcn2 -3605 -5826
Cubn -5532 -3322

Click HERE to show all gene set members

All member genes
young old
Abcd4 4811 4646
Cd320 -4968 -5750
Cubn -5532 -3322
Lmbrd1 1068 406
Mmaa -6691 -6758
Mmab -6646 -6987
Mmachc -6958 -7440
Mmadhc -6728 -7010
Mmut -7065 -7739
Mtr -6792 -7533
Mtrr 47 -4999
Tcn2 -3605 -5826



Mitochondrial-biogenesis

Mitochondrial-biogenesis
metric value
setSize 88
pMANOVA 1.7e-19
p.adjustMANOVA 1.45e-17
s.dist 0.769
s.young -0.53
s.old -0.557
p.young 7.78e-18
p.old 1.67e-19




Top 20 genes
Gene young old
Sod2 -7345 -7817
Atp5o -7347 -7794
Atp5l -7340 -7690
Immt -7219 -7621
Atp5pb -7213 -7607
Atp5g3 -7235 -7573
Atp5a1 -7220 -7504
Atp5c1 -7207 -7515
Hspa9 -7037 -7692
Atp5h -7284 -7352
Atp5j -7206 -7420
Apoo -7092 -7482
Atp5b -7224 -7258
Cycs -7133 -7302
Idh2 -6961 -7381
mt-Atp6 -7229 -7101
Chchd3 -7066 -7212
Sirt5 -6878 -7374
Atp5j2 -7093 -7135
Ppara -6545 -7563

Click HERE to show all gene set members

All member genes
young old
Acss2 -2290 -928
Alas1 -6613 -7012
Apoo -7092 -7482
Apool -5925 -6704
Atf2 -651 -5338
Atp5a1 -7220 -7504
Atp5b -7224 -7258
Atp5c1 -7207 -7515
Atp5d -7173 -6303
Atp5e -7150 -6015
Atp5g3 -7235 -7573
Atp5h -7284 -7352
Atp5j -7206 -7420
Atp5j2 -7093 -7135
Atp5k -5830 -7288
Atp5l -7340 -7690
Atp5o -7347 -7794
Atp5pb -7213 -7607
Calm1 -4595 -4970
Carm1 -1701 -5594
Chchd3 -7066 -7212
Chchd6 -3301 -2838
Chd9 6475 5594
Creb1 -3517 -2558
Crebbp -3332 -3533
Crtc1 4822 3316
Crtc2 2460 2533
Crtc3 3593 2639
Cycs -7133 -7302
Dmac2l -6520 -7171
Dnajc11 -6412 -6403
Esrra -6804 -5371
Gabpa -3716 -6288
Gabpb1 856 -2177
Glud1 -6306 -7705
Hcfc1 -2259 -3907
Hdac3 -6017 -6749
Helz2 -4511 2213
Hspa9 -7037 -7692
Idh2 -6961 -7381
Immt -7219 -7621
Mapk11 704 -262
Mapk12 6483 6788
Mapk14 -6492 -6835
Med1 -2830 -5832
Mef2c 4484 1893
Mef2d -4176 -241
Micos10 -7129 -6291
Micos13 -6641 -6011
mt-Atp6 -7229 -7101
mt-Atp8 -3257 -6724
Mterf1a 3165 -425
Mtx1 -5805 -4557
Mtx2 -6403 -6945
Ncoa1 -4484 -6419
Ncoa2 -3912 -6801
Ncoa6 -1555 -3479
Ncor1 -4730 -6152
Nr1d1 1296 -175
Nrf1 2046 1078
Perm1 -7027 -6909
Polg2 -3186 -2974
Polrmt -6292 -5820
Ppara -6545 -7563
Ppargc1a -6363 -7511
Ppargc1b -5894 -3355
Pprc1 3621 3813
Prkaa2 -6100 -7414
Prkab1 -4034 -7255
Prkab2 7420 5930
Prkag1 -6213 -4030
Prkag2 4029 -2192
Prkag3 5303 4957
Rxra -6194 -6804
Samm50 -7217 -6662
Sirt3 -6560 -6988
Sirt4 -5710 -5696
Sirt5 -6878 -7374
Smarcd3 -4349 -759
Sod2 -7345 -7817
Ssbp1 -4608 -3399
Tbl1x 3008 -5102
Tbl1xr1 4225 -2715
Tfam -6212 -6843
Tfb1m -3569 -5783
Tfb2m -6600 -7199
Tgs1 -4991 -5508
Tmem11 -5461 -4602



Collagen-formation

Collagen-formation
metric value
setSize 75
pMANOVA 1.22e-16
p.adjustMANOVA 8.24e-15
s.dist 0.769
s.young 0.546
s.old 0.542
p.young 3.06e-16
p.old 4.96e-16




Top 20 genes
Gene young old
Col8a2 7452 6978
P3h2 7374 7030
Col8a1 7519 6875
Col5a2 7480 6907
Lamc2 7360 6977
Col12a1 7235 7031
Col16a1 7349 6856
Loxl2 7336 6852
Loxl3 7361 6821
Col1a2 7362 6786
Col14a1 7303 6796
Col4a3 7037 6967
Col11a1 7093 6902
Col27a1 7356 6638
Adamts2 7469 6535
Col4a5 7202 6747
Pcolce 7373 6528
Col4a4 7049 6807
Col1a1 7237 6629
Col9a2 7498 6397

Click HERE to show all gene set members

All member genes
young old
Adamts14 3117 5979
Adamts2 7469 6535
Adamts3 -4916 -4222
Bmp1 7236 6255
Cd151 -3387 -2499
Col11a1 7093 6902
Col11a2 -1021 3528
Col12a1 7235 7031
Col13a1 2636 3872
Col14a1 7303 6796
Col15a1 6814 6634
Col16a1 7349 6856
Col18a1 6116 5391
Col1a1 7237 6629
Col1a2 7362 6786
Col20a1 2825 6268
Col23a1 5725 2177
Col25a1 -1076 474
Col26a1 7193 5097
Col27a1 7356 6638
Col28a1 215 3053
Col3a1 6563 6455
Col4a1 5635 5181
Col4a2 5963 4644
Col4a3 7037 6967
Col4a4 7049 6807
Col4a5 7202 6747
Col4a6 2683 4540
Col5a1 7233 6290
Col5a2 7480 6907
Col5a3 2225 -2736
Col6a1 7176 6438
Col6a2 6971 6524
Col6a3 5781 6084
Col6a6 1479 -6594
Col8a1 7519 6875
Col8a2 7452 6978
Col9a2 7498 6397
Colgalt1 4060 2838
Colgalt2 -4035 -2084
Crtap 6718 3923
Ctsb -39 -2241
Ctss 3818 -193
Dst 5571 5573
Itga6 -5055 -3078
Itgb4 2528 3814
Lama3 1858 -436
Lamb3 -6638 -7066
Lamc2 7360 6977
Lox 7364 6358
Loxl1 7313 5950
Loxl2 7336 6852
Loxl3 7361 6821
Loxl4 6831 6223
Mmp13 -101 -5501
Mmp3 -1265 4045
Mmp9 1226 -6359
P3h1 6856 4702
P3h2 7374 7030
P3h3 7230 6562
P4ha1 4494 6389
P4ha2 -5915 -3841
P4ha3 6223 4289
P4hb 6441 4378
Pcolce 7373 6528
Pcolce2 3514 6586
Plec 1669 2349
Plod1 -2323 2388
Plod2 7080 6224
Plod3 5833 4938
Ppib 5989 3349
Pxdn -3621 -6204
Serpinh1 1466 3868
Tll1 5403 4589
Tll2 -784 -5372



Assembly-of-collagen-fibrils-and-other-multimeric-structures

Assembly-of-collagen-fibrils-and-other-multimeric-structures
metric value
setSize 46
pMANOVA 8.17e-11
p.adjustMANOVA 3.17e-09
s.dist 0.769
s.young 0.576
s.old 0.509
p.young 1.34e-11
p.old 2.38e-09




Top 20 genes
Gene young old
Col8a2 7452 6978
Col8a1 7519 6875
Col5a2 7480 6907
Lamc2 7360 6977
Loxl2 7336 6852
Loxl3 7361 6821
Col1a2 7362 6786
Col4a3 7037 6967
Col11a1 7093 6902
Col27a1 7356 6638
Col4a5 7202 6747
Pcolce 7373 6528
Col4a4 7049 6807
Col1a1 7237 6629
Col9a2 7498 6397
Lox 7364 6358
Col6a1 7176 6438
Col5a1 7233 6290
Col6a2 6971 6524
Bmp1 7236 6255

Click HERE to show all gene set members

All member genes
young old
Bmp1 7236 6255
Cd151 -3387 -2499
Col11a1 7093 6902
Col11a2 -1021 3528
Col15a1 6814 6634
Col18a1 6116 5391
Col1a1 7237 6629
Col1a2 7362 6786
Col27a1 7356 6638
Col3a1 6563 6455
Col4a1 5635 5181
Col4a2 5963 4644
Col4a3 7037 6967
Col4a4 7049 6807
Col4a5 7202 6747
Col5a1 7233 6290
Col5a2 7480 6907
Col5a3 2225 -2736
Col6a1 7176 6438
Col6a2 6971 6524
Col6a3 5781 6084
Col6a6 1479 -6594
Col8a1 7519 6875
Col8a2 7452 6978
Col9a2 7498 6397
Ctsb -39 -2241
Ctss 3818 -193
Dst 5571 5573
Itga6 -5055 -3078
Itgb4 2528 3814
Lama3 1858 -436
Lamb3 -6638 -7066
Lamc2 7360 6977
Lox 7364 6358
Loxl1 7313 5950
Loxl2 7336 6852
Loxl3 7361 6821
Loxl4 6831 6223
Mmp13 -101 -5501
Mmp3 -1265 4045
Mmp9 1226 -6359
Pcolce 7373 6528
Plec 1669 2349
Pxdn -3621 -6204
Tll1 5403 4589
Tll2 -784 -5372



Carnitine-metabolism

Carnitine-metabolism
metric value
setSize 12
pMANOVA 0.00161
p.adjustMANOVA 0.0121
s.dist 0.764
s.young -0.476
s.old -0.598
p.young 0.00431
p.old 0.000337




Top 20 genes
Gene young old
Cpt2 -7007 -7546
Slc25a20 -6911 -7554
Cpt1b -6751 -7032
Slc22a5 -6362 -7316
Prkaa2 -6100 -7414
Rxra -6194 -6804
Thrsp -5942 -5944
Ppard -5588 -4490
Mid1ip1 -5373 -4247

Click HERE to show all gene set members

All member genes
young old
Cpt1a 3375 -3304
Cpt1b -6751 -7032
Cpt2 -7007 -7546
Mid1ip1 -5373 -4247
Ppard -5588 -4490
Prkaa2 -6100 -7414
Prkab2 7420 5930
Prkag2 4029 -2192
Rxra -6194 -6804
Slc22a5 -6362 -7316
Slc25a20 -6911 -7554
Thrsp -5942 -5944



Syndecan-interactions

Syndecan-interactions
metric value
setSize 20
pMANOVA 7.01e-05
p.adjustMANOVA 0.000935
s.dist 0.759
s.young 0.544
s.old 0.529
p.young 2.5e-05
p.old 4.16e-05




Top 20 genes
Gene young old
Sdc2 7435 6631
Itgav 7314 6700
Actn1 7067 6336
Itgb5 7035 6117
Itgb3 7496 5721
Thbs1 6742 6178
Itgb1 6770 5825
Tgfb1 6984 5531
Sdc1 7061 4784
Prkca 5539 5603
Tnc 4757 6330
Cask 4944 6083
Itga2 3765 6228
Sdc3 4012 3827
Itgb4 2528 3814

Click HERE to show all gene set members

All member genes
young old
Actn1 7067 6336
Cask 4944 6083
Fgf2 3347 -4613
Itga2 3765 6228
Itga6 -5055 -3078
Itgav 7314 6700
Itgb1 6770 5825
Itgb3 7496 5721
Itgb4 2528 3814
Itgb5 7035 6117
Prkca 5539 5603
Sdc1 7061 4784
Sdc2 7435 6631
Sdc3 4012 3827
Sdc4 4355 -9
Tgfb1 6984 5531
Thbs1 6742 6178
Tnc 4757 6330
Trappc4 -2363 396
Vtn -7117 -7433



Molecules-associated-with-elastic-fibres

Molecules-associated-with-elastic-fibres
metric value
setSize 28
pMANOVA 1.45e-06
p.adjustMANOVA 2.98e-05
s.dist 0.758
s.young 0.516
s.old 0.554
p.young 2.25e-06
p.old 3.82e-07




Top 20 genes
Gene young old
Tgfb2 7427 6986
Mfap5 7485 6861
Tgfb3 7433 6863
Ltbp3 7432 6685
Itgav 7314 6700
Ltbp2 7174 6826
Mfap4 7221 6243
Fbln2 7256 6211
Bmp4 6772 6517
Ltbp4 7265 5969
Itgb5 7035 6117
Itgb3 7496 5721
Fbln5 6795 6253
Itgb8 6492 6501
Itgb1 6770 5825
Tgfb1 6984 5531
Efemp2 6926 5475
Mfap2 7084 3420
Itga8 3673 5405
Ltbp1 2153 4810

Click HERE to show all gene set members

All member genes
young old
Bmp2 -2270 2145
Bmp4 6772 6517
Bmp7 -4799 -5293
Efemp1 -4901 -7119
Efemp2 6926 5475
Fbln1 -3620 3794
Fbln2 7256 6211
Fbln5 6795 6253
Itga8 3673 5405
Itgav 7314 6700
Itgb1 6770 5825
Itgb3 7496 5721
Itgb5 7035 6117
Itgb6 -4680 -6503
Itgb8 6492 6501
Ltbp1 2153 4810
Ltbp2 7174 6826
Ltbp3 7432 6685
Ltbp4 7265 5969
Mfap1b 2060 3988
Mfap2 7084 3420
Mfap3 919 -6
Mfap4 7221 6243
Mfap5 7485 6861
Tgfb1 6984 5531
Tgfb2 7427 6986
Tgfb3 7433 6863
Vtn -7117 -7433



MET-activates-PTK2-signaling

MET-activates-PTK2-signaling
metric value
setSize 17
pMANOVA 0.000125
p.adjustMANOVA 0.0015
s.dist 0.749
s.young 0.593
s.old 0.458
p.young 2.33e-05
p.old 0.00108




Top 20 genes
Gene young old
Lamc2 7360 6977
Lama2 7478 6628
Src 7196 6795
Lamc1 7347 5936
Met 6093 6741
Itgb1 6770 5825
Lamc3 6611 5684
Itga3 5715 5066
Itga2 3765 6228
Lamb2 2375 4485
Lama4 3147 2662
Hgf 4186 1759

Click HERE to show all gene set members

All member genes
young old
Hgf 4186 1759
Itga2 3765 6228
Itga3 5715 5066
Itgb1 6770 5825
Lama2 7478 6628
Lama3 1858 -436
Lama4 3147 2662
Lama5 5048 -4782
Lamb1 6771 -983
Lamb2 2375 4485
Lamb3 -6638 -7066
Lamc1 7347 5936
Lamc2 7360 6977
Lamc3 6611 5684
Met 6093 6741
Ptk2 1246 -212
Src 7196 6795



Protein-localization

Protein-localization
metric value
setSize 142
pMANOVA 7.41e-29
p.adjustMANOVA 7.9e-27
s.dist 0.742
s.young -0.512
s.old -0.537
p.young 6.06e-26
p.old 2.04e-28




Top 20 genes
Gene young old
Ndufb8 -7343 -7800
Dhrs4 -7344 -7770
Timm23 -7335 -7749
Acot2 -7253 -7797
Phyh -7261 -7709
Gstk1 -7200 -7732
Crat -7321 -7591
Ech1 -7282 -7627
Cs -7238 -7580
Atp5a1 -7220 -7504
Hspa9 -7037 -7692
Gnpat -7105 -7547
Hspd1 -6966 -7697
Pxmp2 -6949 -7658
Grpel1 -7078 -7473
Idh3g -7228 -7314
Ephx2 -6954 -7595
Atp5b -7224 -7258
Cyc1 -7237 -7220
Slc25a4 -7089 -7295

Click HERE to show all gene set members

All member genes
young old
Abcd1 -6190 -6228
Abcd2 -5558 -4862
Abcd3 -6653 -7370
Acbd5 6712 4401
Aco2 -6436 -6977
Acot2 -7253 -7797
Acot4 825 -4529
Acot8 559 -172
Acox1 -4724 -7321
Acox3 1630 -3864
Agps -605 -2899
Aldh3a2 -30 -948
Amacr -6767 -7086
App 6494 6345
Atad1 -3794 -5152
Atp5a1 -7220 -7504
Atp5b -7224 -7258
Bag6 -5266 -4082
Bcs1l -5832 -6564
Caml 994 3005
Cat -2626 -1549
Chchd10 -7262 -6494
Chchd2 -7180 -5992
Chchd3 -7066 -7212
Chchd5 -1580 -3461
Chchd7 -6825 -6448
Cmc2 -6667 -7225
Cmc4 -3869 1658
Coa4 -1599 348
Coa6 -4801 -4707
Coq2 -7039 -7275
Cox19 6674 6213
Crat -7321 -7591
Crot -1116 -3382
Cs -7238 -7580
Cyb5a 4661 2737
Cyc1 -7237 -7220
Ddo -5929 -5213
Decr2 -2640 -3902
Dhrs4 -7344 -7770
Ech1 -7282 -7627
Ehhadh -5758 -7027
Emd -2212 -1010
Ephx2 -6954 -7595
Fis1 -3956 -2973
Fxn -6784 -6569
Get4 -1373 -1432
Gfer -1953 -4416
Gm11808 -5706 -216
Gm45799 -1631 4287
Gnpat -7105 -7547
Grpel1 -7078 -7473
Grpel2 -4955 -6528
Gstk1 -7200 -7732
Hmgcl -6101 -4870
Hmox1 654 381
Hscb -1609 -5700
Hsd17b4 -6387 -7282
Hspa9 -7037 -7692
Hspd1 -6966 -7697
Ide -4424 -4327
Idh1 -3318 -6643
Idh3g -7228 -7314
Ldhd -6770 -7536
Lonp2 -5285 -6862
Mlycd -6864 -7040
Mpv17 -5642 -5830
Mtx1 -5805 -4557
Mtx2 -6403 -6945
Ndufb8 -7343 -7800
Nos2 -5173 -6317
Nudt19 -6768 -6057
Nudt7 -6026 -7008
Pam16 -5409 -4217
Paox 3632 -605
Pecr -5886 -6147
Pex1 -1700 -4722
Pex10 -6076 -6073
Pex11b -3864 -5317
Pex12 2346 -4157
Pex13 -771 -5620
Pex14 809 -2777
Pex16 -3583 -3499
Pex19 -6534 -6309
Pex2 -5398 -6265
Pex26 -2597 -2650
Pex3 1333 -4235
Pex5 5993 2191
Pex6 -6267 -5589
Pex7 -6116 -6538
Phyh -7261 -7709
Pipox 3254 2820
Pitrm1 -5821 -6104
Pmpca -6712 -7102
Pmpcb -5714 -7243
Prnp 7411 6404
Pxmp2 -6949 -7658
Pxmp4 -6593 -7236
Rps27a -1504 -1029
Samm50 -7217 -6662
Scp2 -6736 -7268
Sec61b 5315 1434
Sec61g -4065 -1345
Serp1 5557 2548
Sgta -3667 -3548
Slc25a12 -7001 -7181
Slc25a13 -5896 -6938
Slc25a17 -336 -4956
Slc25a4 -7089 -7295
Stx1a 2912 1003
Stx5a 4418 3544
Taz -5545 -5487
Timm10 -5933 -5648
Timm13 -5069 -2877
Timm17a -6452 -6120
Timm17b -2372 -4104
Timm21 -6376 -7056
Timm22 -3823 -5072
Timm23 -7335 -7749
Timm44 -7154 -7015
Timm50 -6322 -5800
Timm8b -6609 -6897
Timm9 -5723 -5076
Tomm20 -4097 -410
Tomm22 -5748 -5300
Tomm40 -6658 -5282
Tomm6 -3900 -1449
Tomm7 -4071 -4401
Tomm70a -5828 -6506
Tysnd1 -504 -3360
Ubb 5763 -1908
Ubc -1436 -1699
Ube2d1 -4576 -5721
Ube2d2a -681 -3716
Ube2d3 5709 3978
Ube2j2 -2625 -2495
Ubl4a -5513 -5091
Usp9x 4374 -3676
Vamp2 -3875 -96
Vapa 441 -3564
Vdac1 -7008 -7195
Zfand6 -5659 -5819



Prolactin-receptor-signaling

Prolactin-receptor-signaling
metric value
setSize 11
pMANOVA 0.00573
p.adjustMANOVA 0.0332
s.dist 0.731
s.young -0.472
s.old -0.559
p.young 0.00673
p.old 0.00134




Top 20 genes
Gene young old
Stat5b -6561 -6176
Ghr -5355 -6071
Prlr -4651 -6460
Stat5a -5331 -4559
Rbx1 -4743 -4554
Sh2b1 -4224 -4620
Skp1a -2255 -5461
Cul1 -3119 -3855
Ptpn11 -3358 -3525
Btrc -983 -2965

Click HERE to show all gene set members

All member genes
young old
Btrc -983 -2965
Cul1 -3119 -3855
Ghr -5355 -6071
Jak2 2955 -1644
Prlr -4651 -6460
Ptpn11 -3358 -3525
Rbx1 -4743 -4554
Sh2b1 -4224 -4620
Skp1a -2255 -5461
Stat5a -5331 -4559
Stat5b -6561 -6176



Peroxisomal-protein-import

Peroxisomal-protein-import
metric value
setSize 53
pMANOVA 2.97e-12
p.adjustMANOVA 1.52e-10
s.dist 0.729
s.young -0.446
s.old -0.577
p.young 1.95e-08
p.old 3.55e-13




Top 20 genes
Gene young old
Dhrs4 -7344 -7770
Acot2 -7253 -7797
Phyh -7261 -7709
Gstk1 -7200 -7732
Crat -7321 -7591
Ech1 -7282 -7627
Gnpat -7105 -7547
Ephx2 -6954 -7595
Scp2 -6736 -7268
Mlycd -6864 -7040
Amacr -6767 -7086
Hsd17b4 -6387 -7282
Nudt7 -6026 -7008
Nudt19 -6768 -6057
Ehhadh -5758 -7027
Pex7 -6116 -6538
Pex10 -6076 -6073
Lonp2 -5285 -6862
Pecr -5886 -6147
Pex6 -6267 -5589

Click HERE to show all gene set members

All member genes
young old
Acot2 -7253 -7797
Acot4 825 -4529
Acot8 559 -172
Acox1 -4724 -7321
Acox3 1630 -3864
Agps -605 -2899
Amacr -6767 -7086
Cat -2626 -1549
Crat -7321 -7591
Crot -1116 -3382
Ddo -5929 -5213
Decr2 -2640 -3902
Dhrs4 -7344 -7770
Ech1 -7282 -7627
Ehhadh -5758 -7027
Ephx2 -6954 -7595
Gm11808 -5706 -216
Gnpat -7105 -7547
Gstk1 -7200 -7732
Hmgcl -6101 -4870
Hsd17b4 -6387 -7282
Ide -4424 -4327
Idh1 -3318 -6643
Lonp2 -5285 -6862
Mlycd -6864 -7040
Mpv17 -5642 -5830
Nos2 -5173 -6317
Nudt19 -6768 -6057
Nudt7 -6026 -7008
Paox 3632 -605
Pecr -5886 -6147
Pex1 -1700 -4722
Pex10 -6076 -6073
Pex12 2346 -4157
Pex13 -771 -5620
Pex14 809 -2777
Pex2 -5398 -6265
Pex26 -2597 -2650
Pex5 5993 2191
Pex6 -6267 -5589
Pex7 -6116 -6538
Phyh -7261 -7709
Pipox 3254 2820
Rps27a -1504 -1029
Scp2 -6736 -7268
Tysnd1 -504 -3360
Ubb 5763 -1908
Ubc -1436 -1699
Ube2d1 -4576 -5721
Ube2d2a -681 -3716
Ube2d3 5709 3978
Usp9x 4374 -3676
Zfand6 -5659 -5819



Mitochondrial-calcium-ion-transport

Mitochondrial-calcium-ion-transport
metric value
setSize 21
pMANOVA 0.000153
p.adjustMANOVA 0.00176
s.dist 0.71
s.young -0.495
s.old -0.509
p.young 8.64e-05
p.old 5.32e-05




Top 20 genes
Gene young old
Phb -7148 -7279
Vdac1 -7008 -7195
Vdac3 -6938 -7147
Afg3l2 -6709 -7174
Pmpca -6712 -7102
Parl -6531 -7264
Phb2 -7196 -6457
Vdac2 -6648 -6666
Letm1 -6685 -6378
Spg7 -6831 -6169
Pmpcb -5714 -7243
Akap1 -5651 -6902
Stoml2 -6275 -5665
Yme1l1 -1988 -4374
Smdt1 -1291 -178

Click HERE to show all gene set members

All member genes
young old
Afg3l2 -6709 -7174
Akap1 -5651 -6902
Letm1 -6685 -6378
Mcu 2029 -3493
Mcub 1688 607
Micu1 4070 2942
Micu2 6554 5473
Micu3 411 -871
Parl -6531 -7264
Phb -7148 -7279
Phb2 -7196 -6457
Pmpca -6712 -7102
Pmpcb -5714 -7243
Slc8b1 -796 1010
Smdt1 -1291 -178
Spg7 -6831 -6169
Stoml2 -6275 -5665
Vdac1 -7008 -7195
Vdac2 -6648 -6666
Vdac3 -6938 -7147
Yme1l1 -1988 -4374



Chondroitin-sulfate/dermatan-sulfate-metabolism

Chondroitin-sulfate/dermatan-sulfate-metabolism
metric value
setSize 42
pMANOVA 1.03e-08
p.adjustMANOVA 3.3e-07
s.dist 0.707
s.young 0.54
s.old 0.456
p.young 1.42e-09
p.old 3.11e-07




Top 20 genes
Gene young old
Bgn 7481 6830
Cspg4 7500 6779
Dcn 7414 6701
Sdc2 7435 6631
Dse 7298 6706
Dsel 7222 6720
Vcan 7188 6694
Hexa 7315 6493
Chpf2 6949 6362
Gpc6 6891 6273
Chpf 7328 5652
Chsy1 7110 5672
Chsy3 6387 6260
Chst3 6451 6127
Ust 6358 6176
Csgalnact2 6411 5972
Xylt1 6328 6030
Arsb 6684 5613
Sdc1 7061 4784
Ids 6784 4640

Click HERE to show all gene set members

All member genes
young old
Agrn -247 199
Arsb 6684 5613
B3galt6 4154 3582
B3gat2 2242 2141
B3gat3 -677 -1460
B4galt7 -1177 -3787
Bgn 7481 6830
Chpf 7328 5652
Chpf2 6949 6362
Chst11 1137 4315
Chst12 4324 4171
Chst14 5647 3716
Chst15 -359 -4584
Chst3 6451 6127
Chst7 1335 -705
Chsy1 7110 5672
Chsy3 6387 6260
Csgalnact1 2042 -2352
Csgalnact2 6411 5972
Cspg4 7500 6779
Cspg5 -3048 1942
Dcn 7414 6701
Dse 7298 6706
Dsel 7222 6720
Gpc1 -3801 -4293
Gpc3 2127 -5769
Gpc4 -3619 -6582
Gpc6 6891 6273
Hexa 7315 6493
Hexb 5022 5616
Hspg2 6535 3769
Hyal1 4392 6096
Ids 6784 4640
Idua -5121 -5157
Sdc1 7061 4784
Sdc2 7435 6631
Sdc3 4012 3827
Sdc4 4355 -9
Ust 6358 6176
Vcan 7188 6694
Xylt1 6328 6030
Xylt2 2935 -1769



p130Cas-linkage-to-MAPK-signaling-for-integrins

p130Cas-linkage-to-MAPK-signaling-for-integrins
metric value
setSize 14
pMANOVA 0.00195
p.adjustMANOVA 0.0138
s.dist 0.704
s.young 0.545
s.old 0.446
p.young 0.000411
p.old 0.00388




Top 20 genes
Gene young old
Src 7196 6795
Fn1 7320 6491
Itgb3 7496 5721
Tln1 6888 5990
Apbb1ip 6482 6202
Bcar1 7122 5122
Rap1b 6393 4567
Vwf 6524 723
Itga2b 5803 437

Click HERE to show all gene set members

All member genes
young old
Apbb1ip 6482 6202
Bcar1 7122 5122
Crk -1529 -945
Fga -3043 855
Fgb -3889 1327
Fn1 7320 6491
Itga2b 5803 437
Itgb3 7496 5721
Ptk2 1246 -212
Rap1a 3944 -2069
Rap1b 6393 4567
Src 7196 6795
Tln1 6888 5990
Vwf 6524 723



Defects-in-vitamin-and-cofactor-metabolism

Defects-in-vitamin-and-cofactor-metabolism
metric value
setSize 20
pMANOVA 0.000195
p.adjustMANOVA 0.00208
s.dist 0.699
s.young -0.452
s.old -0.533
p.young 0.000461
p.old 3.72e-05




Top 20 genes
Gene young old
Mccc2 -7174 -7704
Mmut -7065 -7739
Pcca -7022 -7738
Mccc1 -6826 -7722
Pccb -7054 -7359
Mmachc -6958 -7440
Mtr -6792 -7533
Mmadhc -6728 -7010
Mmab -6646 -6987
Mmaa -6691 -6758
Cd320 -4968 -5750
Tcn2 -3605 -5826
Cubn -5532 -3322
Pcx -661 -6300

Click HERE to show all gene set members

All member genes
young old
Abcd4 4811 4646
Acaca 3453 -653
Btd 5564 5009
Cd320 -4968 -5750
Cubn -5532 -3322
Hlcs 3308 3956
Lmbrd1 1068 406
Mccc1 -6826 -7722
Mccc2 -7174 -7704
Mmaa -6691 -6758
Mmab -6646 -6987
Mmachc -6958 -7440
Mmadhc -6728 -7010
Mmut -7065 -7739
Mtr -6792 -7533
Mtrr 47 -4999
Pcca -7022 -7738
Pccb -7054 -7359
Pcx -661 -6300
Tcn2 -3605 -5826



Laminin-interactions

Laminin-interactions
metric value
setSize 22
pMANOVA 5.04e-05
p.adjustMANOVA 0.000724
s.dist 0.698
s.young 0.548
s.old 0.433
p.young 8.72e-06
p.old 0.000433




Top 20 genes
Gene young old
Lamc2 7360 6977
Lama2 7478 6628
Itgav 7314 6700
Lamc1 7347 5936
Itgb1 6770 5825
Lamc3 6611 5684
Itga7 6140 5835
Col18a1 6116 5391
Nid1 6799 4441
Itga3 5715 5066
Hspg2 6535 3769
Itga2 3765 6228
Nid2 5838 3132
Lamb2 2375 4485
Itgb4 2528 3814
Lama4 3147 2662

Click HERE to show all gene set members

All member genes
young old
Col18a1 6116 5391
Hspg2 6535 3769
Itga1 -2422 -3850
Itga2 3765 6228
Itga3 5715 5066
Itga6 -5055 -3078
Itga7 6140 5835
Itgav 7314 6700
Itgb1 6770 5825
Itgb4 2528 3814
Lama2 7478 6628
Lama3 1858 -436
Lama4 3147 2662
Lama5 5048 -4782
Lamb1 6771 -983
Lamb2 2375 4485
Lamb3 -6638 -7066
Lamc1 7347 5936
Lamc2 7360 6977
Lamc3 6611 5684
Nid1 6799 4441
Nid2 5838 3132



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0   GGally_2.0.0    beeswarm_0.2.3  gtools_3.8.2   
##  [5] echarts4r_0.3.2 mitch_1.0.6     gplots_3.0.3    reshape2_1.4.4 
##  [9] forcats_0.5.0   stringr_1.4.0   dplyr_1.0.0     purrr_0.3.4    
## [13] readr_1.3.1     tidyr_1.1.0     tibble_3.0.1    ggplot2_3.3.2  
## [17] tidyverse_1.3.0
## 
## loaded via a namespace (and not attached):
##  [1] nlme_3.1-148       bitops_1.0-6       fs_1.4.2           lubridate_1.7.9   
##  [5] RColorBrewer_1.1-2 httr_1.4.1         rprojroot_1.3-2    tools_4.0.2       
##  [9] backports_1.1.8    R6_2.4.1           KernSmooth_2.23-17 DBI_1.1.0         
## [13] colorspace_1.4-1   withr_2.2.0        tidyselect_1.1.0   gridExtra_2.3     
## [17] compiler_4.0.2     cli_2.0.2          rvest_0.3.5        xml2_1.3.2        
## [21] desc_1.2.0         labeling_0.3       caTools_1.18.0     scales_1.1.1      
## [25] digest_0.6.25      rmarkdown_2.3      pkgconfig_2.0.3    htmltools_0.5.0   
## [29] dbplyr_1.4.4       fastmap_1.0.1      highr_0.8          htmlwidgets_1.5.1 
## [33] rlang_0.4.6        readxl_1.3.1       rstudioapi_0.11    shiny_1.5.0       
## [37] generics_0.0.2     farver_2.0.3       jsonlite_1.7.0     magrittr_1.5      
## [41] Rcpp_1.0.4.6       munsell_0.5.0      fansi_0.4.1        lifecycle_0.2.0   
## [45] stringi_1.4.6      yaml_2.2.1         MASS_7.3-51.6      plyr_1.8.6        
## [49] grid_4.0.2         blob_1.2.1         parallel_4.0.2     gdata_2.18.0      
## [53] promises_1.1.1     crayon_1.3.4       lattice_0.20-41    haven_2.3.1       
## [57] hms_0.5.3          knitr_1.29         pillar_1.4.4       reprex_0.3.0      
## [61] glue_1.4.1         evaluate_0.14      modelr_0.1.8       vctrs_0.3.1       
## [65] httpuv_1.5.4       testthat_2.3.2     cellranger_1.1.0   gtable_0.3.0      
## [69] reshape_0.8.8      assertthat_0.2.1   xfun_0.15          mime_0.9          
## [73] xtable_1.8-4       broom_0.5.6        later_1.1.0.1      pbmcapply_1.5.0   
## [77] ellipsis_0.3.1

END of report