Mitch Report

date generated: 2023-12-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	Discovery	Replication
A1BG	0.6788421	5.449947
A1BG-AS1	-3.6425000	-0.532500
A1CF	-3.4320000	-5.874042
A2BP1	5.1382961	6.433508
A2LD1	-1.3829167	6.819167
A2M	-3.2524000	2.005133

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	25371
duplicated_genes_present	0
num_profile_genes_in_sets	10089
num_profile_genes_not_in_sets	15282
profile_pearson_correl	0.72218
profile_spearman_correl	0.50402

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: c2.cp.reactome.v2023.1.Hs.symbols.gmt

Gene set metrics

	Gene sets metrics
num_genesets	1654
num_genesets_excluded	374
num_genesets_included	1280

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 314

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

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## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.Discovery	s.Replication	p.Discovery	p.Replication
REACTOME FORMATION OF LATERAL PLATE MESODERM	5	3.39e-04	3.10e-03	1.260	0.925	0.861	3.39e-04	8.51e-04
REACTOME REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS	8	2.86e-06	3.81e-05	1.260	0.931	0.852	5.09e-06	2.97e-05
REACTOME DOPAMINE RECEPTORS	5	4.36e-04	3.83e-03	1.250	0.895	0.866	5.26e-04	7.99e-04
REACTOME ADRENOCEPTORS	9	1.97e-05	2.24e-04	1.080	0.860	0.651	7.91e-06	7.22e-04
REACTOME VITAMINS	6	6.97e-04	5.73e-03	1.080	0.869	0.635	2.26e-04	7.04e-03
REACTOME CREATION OF C4 AND C2 ACTIVATORS	14	1.20e-07	2.18e-06	1.060	-0.817	-0.672	1.18e-07	1.33e-05
REACTOME FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE	5	5.66e-03	3.36e-02	0.992	-0.807	-0.577	1.78e-03	2.54e-02
REACTOME REGULATION OF GENE EXPRESSION IN ENDOCRINE COMMITTED NEUROG3 PROGENITOR CELLS	5	8.75e-03	4.65e-02	0.974	0.713	0.663	5.76e-03	1.02e-02
REACTOME LECTIN PATHWAY OF COMPLEMENT ACTIVATION	8	6.53e-04	5.51e-03	0.921	-0.770	-0.507	1.63e-04	1.30e-02
REACTOME ORGANIC ANION TRANSPORT	5	9.27e-03	4.86e-02	0.897	-0.789	-0.427	2.24e-03	9.85e-02
REACTOME FORMATION OF AXIAL MESODERM	13	4.03e-05	4.28e-04	0.883	0.614	0.635	1.26e-04	7.31e-05
REACTOME CONJUGATION OF BENZOATE WITH GLYCINE	6	9.65e-03	5.01e-02	0.872	-0.675	-0.552	4.18e-03	1.93e-02
REACTOME DIGESTION OF DIETARY LIPID	7	6.16e-03	3.61e-02	0.827	-0.681	-0.470	1.81e-03	3.14e-02
REACTOME DIGESTION	17	3.78e-06	4.86e-05	0.820	-0.692	-0.441	7.84e-07	1.66e-03
REACTOME HYALURONAN BIOSYNTHESIS AND EXPORT	5	2.92e-02	1.11e-01	0.820	0.478	0.666	6.42e-02	9.86e-03
REACTOME MINERALOCORTICOID BIOSYNTHESIS	6	1.24e-02	6.02e-02	0.819	-0.690	-0.442	3.41e-03	6.11e-02
REACTOME POU5F1 OCT4 SOX2 NANOG REPRESS GENES RELATED TO DIFFERENTIATION	10	1.28e-03	9.91e-03	0.817	0.573	0.583	1.72e-03	1.40e-03
REACTOME NEGATIVE REGULATION OF ACTIVITY OF TFAP2 AP 2 FAMILY TRANSCRIPTION FACTORS	10	1.33e-03	1.02e-02	0.815	0.563	0.589	2.05e-03	1.26e-03
REACTOME FGFRL1 MODULATION OF FGFR1 SIGNALING	13	4.29e-04	3.80e-03	0.773	0.559	0.534	4.83e-04	8.55e-04
REACTOME EPITHELIAL MESENCHYMAL TRANSITION EMT DURING GASTRULATION	6	2.63e-02	1.03e-01	0.765	0.610	0.462	9.61e-03	5.02e-02
REACTOME LINOLEIC ACID LA METABOLISM	7	1.09e-02	5.50e-02	0.757	0.653	0.382	2.77e-03	7.99e-02
REACTOME ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA PLCG	7	2.08e-02	8.86e-02	0.742	0.493	0.555	2.38e-02	1.10e-02
REACTOME ACTIVATION OF TRKA RECEPTORS	6	3.49e-02	1.23e-01	0.733	0.589	0.436	1.24e-02	6.44e-02
REACTOME DEFECTIVE CHST6 CAUSES MCDC1	8	4.97e-03	3.10e-02	0.724	-0.663	-0.290	1.16e-03	1.55e-01
REACTOME TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION	12	1.85e-03	1.36e-02	0.715	0.442	0.562	8.01e-03	7.46e-04
REACTOME AMINO ACID CONJUGATION	9	9.99e-03	5.13e-02	0.713	-0.537	-0.469	5.24e-03	1.49e-02
REACTOME DIGESTION AND ABSORPTION	22	2.50e-06	3.37e-05	0.711	-0.625	-0.339	3.89e-07	5.84e-03
REACTOME MODULATION BY MTB OF HOST IMMUNE SYSTEM	6	3.06e-04	2.83e-03	0.710	0.666	-0.247	4.72e-03	2.94e-01
REACTOME SIGNALING BY LRP5 MUTANTS	6	4.87e-02	1.52e-01	0.709	0.526	0.475	2.55e-02	4.40e-02
REACTOME INITIAL TRIGGERING OF COMPLEMENT	21	1.02e-05	1.22e-04	0.705	-0.599	-0.372	2.02e-06	3.14e-03
REACTOME SYNTHESIS OF LIPOXINS LX	6	4.30e-02	1.42e-01	0.699	0.581	0.389	1.37e-02	9.91e-02
REACTOME CD22 MEDIATED BCR REGULATION	5	8.45e-02	2.25e-01	0.695	0.545	0.431	3.49e-02	9.50e-02
REACTOME ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS	11	5.44e-03	3.28e-02	0.685	0.521	0.445	2.76e-03	1.06e-02
REACTOME REGULATION OF NPAS4 MRNA TRANSLATION	9	2.79e-03	1.94e-02	0.681	0.213	0.647	2.69e-01	7.74e-04
REACTOME VASOPRESSIN LIKE RECEPTORS	5	8.26e-02	2.21e-01	0.677	0.569	0.367	2.75e-02	1.56e-01
REACTOME LIGAND RECEPTOR INTERACTIONS	8	2.32e-02	9.55e-02	0.676	0.535	0.414	8.83e-03	4.28e-02
REACTOME OLFACTORY SIGNALING PATHWAY	347	1.23e-80	2.01e-77	0.674	-0.596	-0.315	5.89e-82	5.07e-24
REACTOME HDL CLEARANCE	5	5.55e-02	1.69e-01	0.674	0.266	0.619	3.03e-01	1.66e-02
REACTOME DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15	8	9.22e-03	4.85e-02	0.668	-0.621	-0.248	2.37e-03	2.24e-01
REACTOME CREATINE METABOLISM	9	2.05e-02	8.76e-02	0.658	0.457	0.474	1.76e-02	1.39e-02
REACTOME TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS	5	8.23e-02	2.20e-01	0.658	0.576	0.317	2.56e-02	2.19e-01
REACTOME POST TRANSCRIPTIONAL SILENCING BY SMALL RNAS	7	5.62e-03	3.36e-02	0.656	0.095	0.649	6.63e-01	2.94e-03
REACTOME NGF INDEPENDANT TRKA ACTIVATION	5	1.03e-01	2.53e-01	0.656	0.537	0.376	3.75e-02	1.45e-01
REACTOME NEF AND SIGNAL TRANSDUCTION	8	3.05e-02	1.13e-01	0.654	0.509	0.411	1.27e-02	4.41e-02
REACTOME DEFECTIVE B4GALT1 CAUSES B4GALT1 CDG CDG 2D	8	1.96e-02	8.52e-02	0.653	-0.572	-0.317	5.11e-03	1.21e-01
REACTOME CIPROFLOXACIN ADME	5	8.04e-02	2.18e-01	0.650	-0.580	-0.293	2.47e-02	2.56e-01
REACTOME RECYCLING OF BILE ACIDS AND SALTS	18	1.78e-04	1.70e-03	0.646	-0.565	-0.313	3.35e-05	2.15e-02
REACTOME GERM LAYER FORMATION AT GASTRULATION	16	1.37e-03	1.04e-02	0.643	0.442	0.467	2.23e-03	1.22e-03
REACTOME NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES	7	5.41e-02	1.67e-01	0.642	0.492	0.412	2.43e-02	5.89e-02
REACTOME DIGESTION OF DIETARY CARBOHYDRATE	6	3.48e-02	1.23e-01	0.637	-0.601	-0.210	1.07e-02	3.72e-01

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.Discovery	s.Replication	p.Discovery	p.Replication
REACTOME FORMATION OF LATERAL PLATE MESODERM	5	3.39e-04	3.10e-03	1.26000	0.925000	8.61e-01	3.39e-04	8.51e-04
REACTOME REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS	8	2.86e-06	3.81e-05	1.26000	0.931000	8.52e-01	5.09e-06	2.97e-05
REACTOME DOPAMINE RECEPTORS	5	4.36e-04	3.83e-03	1.25000	0.895000	8.66e-01	5.26e-04	7.99e-04
REACTOME ADRENOCEPTORS	9	1.97e-05	2.24e-04	1.08000	0.860000	6.51e-01	7.91e-06	7.22e-04
REACTOME VITAMINS	6	6.97e-04	5.73e-03	1.08000	0.869000	6.35e-01	2.26e-04	7.04e-03
REACTOME CREATION OF C4 AND C2 ACTIVATORS	14	1.20e-07	2.18e-06	1.06000	-0.817000	-6.72e-01	1.18e-07	1.33e-05
REACTOME FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE	5	5.66e-03	3.36e-02	0.99200	-0.807000	-5.77e-01	1.78e-03	2.54e-02
REACTOME REGULATION OF GENE EXPRESSION IN ENDOCRINE COMMITTED NEUROG3 PROGENITOR CELLS	5	8.75e-03	4.65e-02	0.97400	0.713000	6.63e-01	5.76e-03	1.02e-02
REACTOME LECTIN PATHWAY OF COMPLEMENT ACTIVATION	8	6.53e-04	5.51e-03	0.92100	-0.770000	-5.07e-01	1.63e-04	1.30e-02
REACTOME ORGANIC ANION TRANSPORT	5	9.27e-03	4.86e-02	0.89700	-0.789000	-4.27e-01	2.24e-03	9.85e-02
REACTOME FORMATION OF AXIAL MESODERM	13	4.03e-05	4.28e-04	0.88300	0.614000	6.35e-01	1.26e-04	7.31e-05
REACTOME CONJUGATION OF BENZOATE WITH GLYCINE	6	9.65e-03	5.01e-02	0.87200	-0.675000	-5.52e-01	4.18e-03	1.93e-02
REACTOME DIGESTION OF DIETARY LIPID	7	6.16e-03	3.61e-02	0.82700	-0.681000	-4.70e-01	1.81e-03	3.14e-02
REACTOME DIGESTION	17	3.78e-06	4.86e-05	0.82000	-0.692000	-4.41e-01	7.84e-07	1.66e-03
REACTOME HYALURONAN BIOSYNTHESIS AND EXPORT	5	2.92e-02	1.11e-01	0.82000	0.478000	6.66e-01	6.42e-02	9.86e-03
REACTOME MINERALOCORTICOID BIOSYNTHESIS	6	1.24e-02	6.02e-02	0.81900	-0.690000	-4.42e-01	3.41e-03	6.11e-02
REACTOME POU5F1 OCT4 SOX2 NANOG REPRESS GENES RELATED TO DIFFERENTIATION	10	1.28e-03	9.91e-03	0.81700	0.573000	5.83e-01	1.72e-03	1.40e-03
REACTOME NEGATIVE REGULATION OF ACTIVITY OF TFAP2 AP 2 FAMILY TRANSCRIPTION FACTORS	10	1.33e-03	1.02e-02	0.81500	0.563000	5.89e-01	2.05e-03	1.26e-03
REACTOME FGFRL1 MODULATION OF FGFR1 SIGNALING	13	4.29e-04	3.80e-03	0.77300	0.559000	5.34e-01	4.83e-04	8.55e-04
REACTOME EPITHELIAL MESENCHYMAL TRANSITION EMT DURING GASTRULATION	6	2.63e-02	1.03e-01	0.76500	0.610000	4.62e-01	9.61e-03	5.02e-02
REACTOME LINOLEIC ACID LA METABOLISM	7	1.09e-02	5.50e-02	0.75700	0.653000	3.82e-01	2.77e-03	7.99e-02
REACTOME ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA PLCG	7	2.08e-02	8.86e-02	0.74200	0.493000	5.55e-01	2.38e-02	1.10e-02
REACTOME ACTIVATION OF TRKA RECEPTORS	6	3.49e-02	1.23e-01	0.73300	0.589000	4.36e-01	1.24e-02	6.44e-02
REACTOME DEFECTIVE CHST6 CAUSES MCDC1	8	4.97e-03	3.10e-02	0.72400	-0.663000	-2.90e-01	1.16e-03	1.55e-01
REACTOME TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION	12	1.85e-03	1.36e-02	0.71500	0.442000	5.62e-01	8.01e-03	7.46e-04
REACTOME AMINO ACID CONJUGATION	9	9.99e-03	5.13e-02	0.71300	-0.537000	-4.69e-01	5.24e-03	1.49e-02
REACTOME DIGESTION AND ABSORPTION	22	2.50e-06	3.37e-05	0.71100	-0.625000	-3.39e-01	3.89e-07	5.84e-03
REACTOME MODULATION BY MTB OF HOST IMMUNE SYSTEM	6	3.06e-04	2.83e-03	0.71000	0.666000	-2.47e-01	4.72e-03	2.94e-01
REACTOME SIGNALING BY LRP5 MUTANTS	6	4.87e-02	1.52e-01	0.70900	0.526000	4.75e-01	2.55e-02	4.40e-02
REACTOME INITIAL TRIGGERING OF COMPLEMENT	21	1.02e-05	1.22e-04	0.70500	-0.599000	-3.72e-01	2.02e-06	3.14e-03
REACTOME SYNTHESIS OF LIPOXINS LX	6	4.30e-02	1.42e-01	0.69900	0.581000	3.89e-01	1.37e-02	9.91e-02
REACTOME CD22 MEDIATED BCR REGULATION	5	8.45e-02	2.25e-01	0.69500	0.545000	4.31e-01	3.49e-02	9.50e-02
REACTOME ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS	11	5.44e-03	3.28e-02	0.68500	0.521000	4.45e-01	2.76e-03	1.06e-02
REACTOME REGULATION OF NPAS4 MRNA TRANSLATION	9	2.79e-03	1.94e-02	0.68100	0.213000	6.47e-01	2.69e-01	7.74e-04
REACTOME VASOPRESSIN LIKE RECEPTORS	5	8.26e-02	2.21e-01	0.67700	0.569000	3.67e-01	2.75e-02	1.56e-01
REACTOME LIGAND RECEPTOR INTERACTIONS	8	2.32e-02	9.55e-02	0.67600	0.535000	4.14e-01	8.83e-03	4.28e-02
REACTOME OLFACTORY SIGNALING PATHWAY	347	1.23e-80	2.01e-77	0.67400	-0.596000	-3.15e-01	5.89e-82	5.07e-24
REACTOME HDL CLEARANCE	5	5.55e-02	1.69e-01	0.67400	0.266000	6.19e-01	3.03e-01	1.66e-02
REACTOME DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15	8	9.22e-03	4.85e-02	0.66800	-0.621000	-2.48e-01	2.37e-03	2.24e-01
REACTOME CREATINE METABOLISM	9	2.05e-02	8.76e-02	0.65800	0.457000	4.74e-01	1.76e-02	1.39e-02
REACTOME TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS	5	8.23e-02	2.20e-01	0.65800	0.576000	3.17e-01	2.56e-02	2.19e-01
REACTOME POST TRANSCRIPTIONAL SILENCING BY SMALL RNAS	7	5.62e-03	3.36e-02	0.65600	0.095000	6.49e-01	6.63e-01	2.94e-03
REACTOME NGF INDEPENDANT TRKA ACTIVATION	5	1.03e-01	2.53e-01	0.65600	0.537000	3.76e-01	3.75e-02	1.45e-01
REACTOME NEF AND SIGNAL TRANSDUCTION	8	3.05e-02	1.13e-01	0.65400	0.509000	4.11e-01	1.27e-02	4.41e-02
REACTOME DEFECTIVE B4GALT1 CAUSES B4GALT1 CDG CDG 2D	8	1.96e-02	8.52e-02	0.65300	-0.572000	-3.17e-01	5.11e-03	1.21e-01
REACTOME CIPROFLOXACIN ADME	5	8.04e-02	2.18e-01	0.65000	-0.580000	-2.93e-01	2.47e-02	2.56e-01
REACTOME RECYCLING OF BILE ACIDS AND SALTS	18	1.78e-04	1.70e-03	0.64600	-0.565000	-3.13e-01	3.35e-05	2.15e-02
REACTOME GERM LAYER FORMATION AT GASTRULATION	16	1.37e-03	1.04e-02	0.64300	0.442000	4.67e-01	2.23e-03	1.22e-03
REACTOME NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES	7	5.41e-02	1.67e-01	0.64200	0.492000	4.12e-01	2.43e-02	5.89e-02
REACTOME DIGESTION OF DIETARY CARBOHYDRATE	6	3.48e-02	1.23e-01	0.63700	-0.601000	-2.10e-01	1.07e-02	3.72e-01
REACTOME ERYTHROPOIETIN ACTIVATES STAT5	7	6.25e-02	1.84e-01	0.62700	0.472000	4.13e-01	3.04e-02	5.86e-02
REACTOME CHOLINE CATABOLISM	6	7.52e-02	2.09e-01	0.62500	0.328000	5.32e-01	1.64e-01	2.41e-02
REACTOME MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS	7	5.97e-02	1.78e-01	0.62400	0.496000	3.79e-01	2.30e-02	8.24e-02
REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	15	3.64e-03	2.43e-02	0.61300	0.428000	4.39e-01	4.14e-03	3.25e-03
REACTOME SEROTONIN RECEPTORS	11	1.18e-02	5.85e-02	0.60900	0.330000	5.12e-01	5.82e-02	3.25e-03
REACTOME FLT3 SIGNALING BY CBL MUTANTS	7	6.73e-04	5.63e-03	0.60900	0.545000	-2.70e-01	1.24e-02	2.16e-01
REACTOME BICARBONATE TRANSPORTERS	10	1.80e-02	7.99e-02	0.60600	-0.511000	-3.26e-01	5.10e-03	7.44e-02
REACTOME RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS	5	1.50e-01	3.22e-01	0.60600	0.481000	3.69e-01	6.24e-02	1.53e-01
REACTOME SARS COV 1 MODULATES HOST TRANSLATION MACHINERY	33	3.57e-13	2.65e-11	0.60300	0.114000	-5.92e-01	2.56e-01	3.84e-09
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH CDK5	6	5.78e-02	1.75e-01	0.60100	0.558000	2.21e-01	1.78e-02	3.49e-01
REACTOME LYSOSPHINGOLIPID AND LPA RECEPTORS	9	1.15e-02	5.77e-02	0.60000	0.566000	1.99e-01	3.26e-03	3.02e-01
REACTOME GASTRULATION	48	6.00e-08	1.26e-06	0.58800	0.435000	3.96e-01	1.78e-07	2.08e-06
REACTOME INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA	11	1.51e-02	6.87e-02	0.58300	-0.502000	-2.98e-01	3.96e-03	8.72e-02
REACTOME ASPIRIN ADME	42	3.50e-07	5.84e-06	0.57400	-0.478000	-3.17e-01	8.25e-08	3.71e-04
REACTOME SIGNALING BY MEMBRANE TETHERED FUSIONS OF PDGFRA OR PDGFRB	5	1.94e-01	3.75e-01	0.57300	0.420000	3.90e-01	1.04e-01	1.31e-01
REACTOME ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS	5	1.93e-01	3.75e-01	0.57200	0.376000	4.31e-01	1.46e-01	9.54e-02
REACTOME REGULATION OF PTEN MRNA TRANSLATION	9	1.23e-02	6.02e-02	0.56700	0.141000	5.49e-01	4.62e-01	4.34e-03
REACTOME MOLYBDENUM COFACTOR BIOSYNTHESIS	6	9.00e-02	2.33e-01	0.56500	0.516000	2.31e-01	2.85e-02	3.27e-01
REACTOME EUKARYOTIC TRANSLATION ELONGATION	87	4.40e-32	8.01e-30	0.56200	0.180000	-5.33e-01	3.71e-03	7.95e-18
REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	16	5.93e-03	3.50e-02	0.56200	0.357000	4.33e-01	1.33e-02	2.68e-03
REACTOME VOLTAGE GATED POTASSIUM CHANNELS	42	2.86e-06	3.81e-05	0.54700	0.345000	4.24e-01	1.07e-04	2.00e-06
REACTOME ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	1.66e-02	7.51e-02	0.54500	0.476000	2.65e-01	4.27e-03	1.12e-01
REACTOME COMPLEMENT CASCADE	54	3.21e-08	7.40e-07	0.54300	-0.456000	-2.96e-01	6.91e-09	1.70e-04
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27 HYDROXYCHOLESTEROL	15	7.25e-03	4.11e-02	0.54200	-0.465000	-2.79e-01	1.81e-03	6.16e-02
REACTOME NGF STIMULATED TRANSCRIPTION	38	2.66e-08	6.23e-07	0.54100	0.528000	1.22e-01	1.80e-08	1.94e-01
REACTOME RECYCLING OF EIF2 GDP	7	2.15e-03	1.53e-02	0.54100	0.336000	-4.24e-01	1.23e-01	5.22e-02
REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	30	1.65e-04	1.59e-03	0.53900	-0.369000	-3.93e-01	4.61e-04	1.95e-04
REACTOME PROSTANOID LIGAND RECEPTORS	9	4.45e-02	1.44e-01	0.53800	0.480000	2.43e-01	1.26e-02	2.06e-01
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	104	4.25e-35	1.16e-32	0.53700	0.177000	-5.07e-01	1.76e-03	3.94e-19
REACTOME EICOSANOIDS	12	3.14e-02	1.15e-01	0.53700	-0.360000	-3.98e-01	3.09e-02	1.70e-02
REACTOME RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	94	1.92e-32	3.92e-30	0.53500	0.201000	-4.96e-01	7.47e-04	9.19e-17
REACTOME TERMINAL PATHWAY OF COMPLEMENT	8	9.76e-02	2.45e-01	0.53500	-0.414000	-3.38e-01	4.24e-02	9.81e-02
REACTOME DEFECTIVE CHSY1 CAUSES TPBS	7	1.33e-01	3.00e-01	0.53400	0.407000	3.46e-01	6.23e-02	1.13e-01
REACTOME NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	15	1.50e-02	6.87e-02	0.53000	0.378000	3.71e-01	1.13e-02	1.27e-02
REACTOME SIGNALING BY MST1	5	2.45e-01	4.38e-01	0.52900	0.396000	3.51e-01	1.25e-01	1.74e-01
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	17	8.70e-03	4.65e-02	0.52600	0.343000	3.99e-01	1.44e-02	4.39e-03
REACTOME REGULATION OF BETA CELL DEVELOPMENT	41	1.03e-05	1.23e-04	0.52500	0.331000	4.07e-01	2.49e-04	6.32e-06
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH PI3K	7	6.68e-02	1.92e-01	0.52400	0.498000	1.64e-01	2.26e-02	4.52e-01
REACTOME BIOSYNTHESIS OF EPA DERIVED SPMS	6	1.57e-01	3.29e-01	0.52000	0.453000	2.56e-01	5.47e-02	2.78e-01
REACTOME AMINE LIGAND BINDING RECEPTORS	40	5.29e-06	6.66e-05	0.51900	0.262000	4.48e-01	4.09e-03	9.21e-07
REACTOME FRUCTOSE CATABOLISM	5	2.50e-01	4.43e-01	0.51900	-0.411000	-3.18e-01	1.12e-01	2.18e-01
REACTOME SENSORY PERCEPTION	551	2.10e-78	1.71e-75	0.51800	-0.468000	-2.22e-01	1.10e-79	4.47e-19
REACTOME REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	15	1.84e-02	8.13e-02	0.51600	0.381000	3.48e-01	1.07e-02	1.96e-02
REACTOME TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	30	3.48e-04	3.16e-03	0.51500	0.350000	3.78e-01	9.07e-04	3.34e-04
REACTOME BH3 ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI APOPTOTIC BCL 2 MEMBERS	9	6.63e-03	3.86e-02	0.51500	0.514000	-2.37e-02	7.55e-03	9.02e-01
REACTOME NTRK2 ACTIVATES RAC1	5	2.12e-01	3.99e-01	0.51200	0.455000	2.35e-01	7.80e-02	3.63e-01
REACTOME PTK6 REGULATES CELL CYCLE	6	1.29e-02	6.17e-02	0.51200	0.209000	-4.68e-01	3.76e-01	4.73e-02
REACTOME RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES TREGS	9	6.43e-02	1.87e-01	0.51100	-0.240000	-4.51e-01	2.12e-01	1.92e-02
REACTOME FIBRONECTIN MATRIX FORMATION	6	1.78e-01	3.57e-01	0.50800	-0.436000	-2.62e-01	6.46e-02	2.66e-01
REACTOME EUKARYOTIC TRANSLATION INITIATION	110	1.61e-33	3.77e-31	0.50500	0.182000	-4.71e-01	9.53e-04	1.25e-17
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING	5	2.67e-01	4.61e-01	0.50400	0.303000	4.03e-01	2.41e-01	1.18e-01
REACTOME BETA OXIDATION OF LAUROYL COA TO DECANOYL COA COA	5	2.13e-01	4.02e-01	0.50400	0.454000	2.18e-01	7.89e-02	3.98e-01
REACTOME DRUG MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY	5	2.43e-02	9.82e-02	0.49600	0.347000	-3.54e-01	1.78e-01	1.71e-01
REACTOME SARS COV 2 MODULATES HOST TRANSLATION MACHINERY	46	4.59e-13	3.13e-11	0.49400	0.132000	-4.76e-01	1.21e-01	2.28e-08
REACTOME ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE	11	1.23e-02	6.02e-02	0.49300	-0.485000	-9.02e-02	5.38e-03	6.05e-01
REACTOME KERATINIZATION	210	2.55e-25	2.60e-23	0.49300	-0.423000	-2.53e-01	3.72e-26	2.49e-10
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	11	4.50e-04	3.93e-03	0.49000	0.417000	-2.58e-01	1.67e-02	1.39e-01
REACTOME CD28 DEPENDENT VAV1 PATHWAY	11	2.82e-02	1.09e-01	0.48900	0.459000	1.68e-01	8.34e-03	3.33e-01
REACTOME SIGNALING BY ACTIVIN	15	1.45e-02	6.70e-02	0.48700	0.434000	2.20e-01	3.60e-03	1.39e-01
REACTOME ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	9	1.21e-01	2.79e-01	0.48500	0.338000	3.48e-01	7.92e-02	7.03e-02
REACTOME SYNTHESIS OF EPOXY EET AND DIHYDROXYEICOSATRIENOIC ACIDS DHET	8	1.52e-01	3.24e-01	0.48500	-0.327000	-3.58e-01	1.09e-01	7.94e-02
REACTOME FASL CD95L SIGNALING	5	2.93e-02	1.11e-01	0.48400	0.321000	-3.62e-01	2.14e-01	1.61e-01
REACTOME NONSENSE MEDIATED DECAY NMD	107	1.72e-29	2.56e-27	0.48000	0.171000	-4.49e-01	2.18e-03	9.78e-16
REACTOME DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A	5	1.62e-01	3.35e-01	0.47900	-0.468000	-1.03e-01	6.98e-02	6.90e-01
REACTOME FLT3 SIGNALING THROUGH SRC FAMILY KINASES	6	4.74e-02	1.50e-01	0.47900	0.477000	-4.83e-02	4.31e-02	8.38e-01
REACTOME NRCAM INTERACTIONS	6	2.52e-01	4.44e-01	0.47900	-0.319000	-3.57e-01	1.76e-01	1.30e-01
REACTOME PI 3K CASCADE FGFR1	21	8.28e-03	4.53e-02	0.47700	0.354000	3.20e-01	4.96e-03	1.11e-02
REACTOME METALLOTHIONEINS BIND METALS	11	4.68e-02	1.49e-01	0.47700	0.431000	2.05e-01	1.34e-02	2.38e-01
REACTOME FBXW7 MUTANTS AND NOTCH1 IN CANCER	5	2.93e-01	4.84e-01	0.47300	0.401000	2.51e-01	1.21e-01	3.30e-01
REACTOME ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	4.60e-03	2.94e-02	0.47300	0.463000	-9.49e-02	1.12e-02	6.03e-01
REACTOME SHC MEDIATED CASCADE FGFR1	21	8.99e-03	4.74e-02	0.47200	0.356000	3.11e-01	4.76e-03	1.37e-02
REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV 1 INFECTION	5	7.66e-02	2.11e-01	0.47200	0.069500	-4.67e-01	7.88e-01	7.06e-02
REACTOME ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	12	6.29e-02	1.84e-01	0.47100	0.281000	3.78e-01	9.16e-02	2.35e-02
REACTOME CROSS PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS PHAGOSOMES	6	2.51e-01	4.43e-01	0.47000	-0.379000	-2.78e-01	1.08e-01	2.38e-01
REACTOME ESTROGEN BIOSYNTHESIS	6	2.19e-01	4.08e-01	0.47000	-0.229000	-4.10e-01	3.32e-01	8.18e-02
REACTOME GRB7 EVENTS IN ERBB2 SIGNALING	5	3.20e-01	4.97e-01	0.46900	0.375000	2.82e-01	1.47e-01	2.76e-01
REACTOME MET INTERACTS WITH TNS PROTEINS	5	3.03e-01	4.90e-01	0.46800	-0.395000	-2.51e-01	1.27e-01	3.30e-01
REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	19	6.61e-03	3.86e-02	0.46700	0.420000	2.05e-01	1.54e-03	1.22e-01
REACTOME SIGNALING BY RNF43 MUTANTS	8	1.76e-01	3.55e-01	0.46700	0.326000	3.33e-01	1.10e-01	1.03e-01
REACTOME REGULATION OF FZD BY UBIQUITINATION	21	4.88e-03	3.07e-02	0.46600	0.411000	2.19e-01	1.11e-03	8.21e-02
REACTOME GLUCOCORTICOID BIOSYNTHESIS	10	1.13e-01	2.67e-01	0.46500	-0.304000	-3.52e-01	9.55e-02	5.38e-02
REACTOME FGFR1C LIGAND BINDING AND ACTIVATION	11	9.33e-02	2.38e-01	0.46500	0.332000	3.26e-01	5.66e-02	6.14e-02
REACTOME OPSINS	7	4.60e-02	1.47e-01	0.46400	-0.464000	6.58e-03	3.33e-02	9.76e-01
REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	12	7.56e-02	2.09e-01	0.46400	0.333000	3.24e-01	4.56e-02	5.23e-02
REACTOME HISTIDINE CATABOLISM	8	9.60e-02	2.43e-01	0.46400	-0.436000	-1.58e-01	3.27e-02	4.40e-01
REACTOME RELEASE OF HH NP FROM THE SECRETING CELL	8	1.78e-01	3.57e-01	0.46300	0.350000	3.03e-01	8.65e-02	1.37e-01
REACTOME SERINE BIOSYNTHESIS	9	2.01e-02	8.63e-02	0.46300	0.463000	-3.73e-03	1.62e-02	9.85e-01
REACTOME REGULATION OF BACH1 ACTIVITY	11	5.00e-03	3.11e-02	0.46200	0.459000	-5.62e-02	8.41e-03	7.47e-01
REACTOME DEFECTIVE CHST14 CAUSES EDS MUSCULOCONTRACTURAL TYPE	7	1.72e-01	3.50e-01	0.46200	0.410000	2.14e-01	6.05e-02	3.28e-01
REACTOME SELENOAMINO ACID METABOLISM	101	2.48e-25	2.60e-23	0.46000	0.155000	-4.33e-01	7.00e-03	5.13e-14
REACTOME TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS	14	3.83e-02	1.32e-01	0.46000	0.243000	3.91e-01	1.15e-01	1.14e-02
REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	16	2.21e-02	9.18e-02	0.46000	0.397000	2.31e-01	5.95e-03	1.09e-01
REACTOME PHYSIOLOGICAL FACTORS	14	5.32e-02	1.65e-01	0.45800	0.321000	3.28e-01	3.78e-02	3.37e-02
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	14	4.97e-02	1.54e-01	0.45800	0.358000	2.86e-01	2.05e-02	6.36e-02
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	53	5.95e-13	3.89e-11	0.45800	0.123000	-4.41e-01	1.20e-01	2.77e-08
REACTOME FRS MEDIATED FGFR1 SIGNALING	23	7.97e-03	4.40e-02	0.45700	0.345000	3.00e-01	4.18e-03	1.29e-02
REACTOME LOSS OF FUNCTION OF SMAD2 3 IN CANCER	7	1.93e-01	3.75e-01	0.45600	0.394000	2.30e-01	7.10e-02	2.92e-01
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX IN CANCER	8	1.50e-01	3.21e-01	0.45500	0.397000	2.21e-01	5.17e-02	2.79e-01
REACTOME CHYLOMICRON ASSEMBLY	10	1.26e-01	2.87e-01	0.45300	-0.343000	-2.96e-01	6.02e-02	1.05e-01
REACTOME RUNX3 REGULATES BCL2L11 BIM TRANSCRIPTION	5	3.53e-01	5.35e-01	0.45300	0.348000	2.90e-01	1.78e-01	2.61e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	14	8.12e-03	4.47e-02	0.45200	0.074500	4.46e-01	6.29e-01	3.85e-03
REACTOME ANTIMICROBIAL PEPTIDES	76	1.94e-07	3.38e-06	0.45200	-0.317000	-3.22e-01	1.72e-06	1.19e-06
REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	9.13e-02	2.35e-01	0.45100	0.373000	2.54e-01	3.21e-02	1.45e-01
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	10	1.01e-01	2.50e-01	0.44900	0.390000	2.24e-01	3.28e-02	2.21e-01
REACTOME FOLDING OF ACTIN BY CCT TRIC	10	2.99e-03	2.07e-02	0.44700	0.230000	-3.83e-01	2.07e-01	3.58e-02
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	14	5.88e-02	1.76e-01	0.44500	-0.279000	-3.47e-01	7.04e-02	2.46e-02
REACTOME DEFECTIVE GALNT3 CAUSES HFTC	16	3.33e-02	1.19e-01	0.44500	-0.370000	-2.46e-01	1.03e-02	8.85e-02
REACTOME RELAXIN RECEPTORS	8	7.67e-02	2.11e-01	0.44400	-0.436000	-8.53e-02	3.28e-02	6.76e-01
REACTOME SYNTHESIS OF 12 EICOSATETRAENOIC ACID DERIVATIVES	7	6.23e-02	1.84e-01	0.44300	0.443000	-1.98e-03	4.23e-02	9.93e-01
REACTOME ERYTHROPOIETIN ACTIVATES RAS	14	3.77e-02	1.30e-01	0.44300	0.395000	2.00e-01	1.04e-02	1.95e-01
REACTOME TRANSCRIPTIONAL REGULATION BY MECP2	60	6.67e-06	8.20e-05	0.44200	0.280000	3.42e-01	1.71e-04	4.53e-06
REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	21	8.36e-03	4.55e-02	0.44200	0.209000	3.90e-01	9.75e-02	1.99e-03
REACTOME SOS MEDIATED SIGNALLING	7	2.52e-01	4.45e-01	0.44200	0.334000	2.90e-01	1.26e-01	1.85e-01
REACTOME FORMATION OF THE CORNIFIED ENVELOPE	125	8.98e-13	5.44e-11	0.44000	-0.385000	-2.14e-01	1.05e-13	3.50e-05
REACTOME TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION	5	2.02e-01	3.87e-01	0.44000	0.433000	7.84e-02	9.38e-02	7.61e-01
REACTOME MITOCHONDRIAL UNCOUPLING	5	2.78e-01	4.71e-01	0.43700	0.409000	1.54e-01	1.13e-01	5.52e-01
REACTOME NEF MEDIATED CD8 DOWN REGULATION	7	1.86e-01	3.68e-01	0.43500	0.173000	3.99e-01	4.27e-01	6.76e-02
REACTOME TOXICITY OF BOTULINUM TOXIN TYPE D BOTD	5	5.85e-02	1.76e-01	0.43400	0.287000	-3.25e-01	2.66e-01	2.08e-01
REACTOME CHYLOMICRON REMODELING	10	1.10e-01	2.63e-01	0.43300	-0.384000	-2.02e-01	3.57e-02	2.69e-01
REACTOME FGFR3 LIGAND BINDING AND ACTIVATION	12	1.05e-01	2.57e-01	0.43300	0.286000	3.25e-01	8.67e-02	5.13e-02
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	24	8.31e-03	4.53e-02	0.43200	-0.358000	-2.41e-01	2.38e-03	4.11e-02
REACTOME HEME DEGRADATION	15	5.78e-02	1.75e-01	0.43200	-0.336000	-2.71e-01	2.41e-02	6.96e-02
REACTOME MATURATION OF PROTEIN 3A	9	1.37e-01	3.05e-01	0.43100	0.198000	3.83e-01	3.04e-01	4.64e-02
REACTOME BIOSYNTHESIS OF MARESIN LIKE SPMS	6	2.72e-01	4.64e-01	0.42900	-0.381000	-1.98e-01	1.06e-01	4.01e-01
REACTOME SYNTHESIS OF 16 20 HYDROXYEICOSATETRAENOIC ACIDS HETE	9	1.92e-01	3.74e-01	0.42900	-0.295000	-3.10e-01	1.25e-01	1.07e-01
REACTOME METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS	6	3.36e-01	5.17e-01	0.42700	-0.308000	-2.95e-01	1.91e-01	2.10e-01
REACTOME DEFECTIVE C1GALT1C1 CAUSES TNPS	16	4.06e-02	1.36e-01	0.42600	-0.363000	-2.23e-01	1.20e-02	1.22e-01
REACTOME FERTILIZATION	26	5.46e-03	3.28e-02	0.42500	-0.363000	-2.22e-01	1.36e-03	5.00e-02
REACTOME ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	11	1.26e-02	6.05e-02	0.42500	0.423000	-4.00e-02	1.51e-02	8.18e-01
REACTOME TRAIL SIGNALING	8	3.18e-02	1.17e-01	0.42500	0.417000	-8.03e-02	4.09e-02	6.94e-01
REACTOME SMAC XIAP REGULATED APOPTOTIC RESPONSE	6	6.70e-02	1.92e-01	0.42500	0.412000	-1.05e-01	8.07e-02	6.56e-01
REACTOME INTERLEUKIN 36 PATHWAY	7	2.84e-01	4.77e-01	0.42500	-0.296000	-3.04e-01	1.75e-01	1.64e-01
REACTOME FGFR1B LIGAND BINDING AND ACTIVATION	6	3.12e-01	4.94e-01	0.42400	0.233000	3.55e-01	3.24e-01	1.33e-01
REACTOME SYNTHESIS OF 5 EICOSATETRAENOIC ACIDS	9	4.61e-02	1.47e-01	0.42400	0.423000	2.24e-02	2.79e-02	9.07e-01
REACTOME SYNTHESIS OF GDP MANNOSE	5	1.53e-01	3.26e-01	0.42300	0.422000	-1.79e-02	1.02e-01	9.45e-01
REACTOME JOSEPHIN DOMAIN DUBS	10	5.44e-03	3.28e-02	0.42000	0.240000	-3.44e-01	1.89e-01	5.93e-02
REACTOME REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR	11	1.31e-01	2.96e-01	0.41800	0.342000	2.41e-01	4.94e-02	1.67e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH RAS	9	8.68e-02	2.29e-01	0.41800	0.406000	9.60e-02	3.47e-02	6.18e-01
REACTOME GLUCURONIDATION	23	1.25e-02	6.02e-02	0.41700	-0.353000	-2.22e-01	3.38e-03	6.55e-02
REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	39	7.00e-09	2.01e-07	0.41600	-0.378000	1.74e-01	4.37e-05	5.98e-02
REACTOME REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA CARBOXYLATED PROTEINS	8	1.73e-02	7.75e-02	0.41600	-0.350000	2.24e-01	8.62e-02	2.72e-01
REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	3.19e-03	2.19e-02	0.41600	0.284000	-3.04e-01	1.03e-01	8.12e-02
REACTOME SUMOYLATION OF TRANSCRIPTION FACTORS	20	3.19e-02	1.17e-01	0.41500	0.301000	2.87e-01	1.99e-02	2.65e-02
REACTOME NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY	6	2.83e-01	4.76e-01	0.41500	0.179000	3.75e-01	4.48e-01	1.12e-01
REACTOME PEXOPHAGY	11	5.39e-03	3.28e-02	0.41500	0.380000	-1.67e-01	2.91e-02	3.37e-01
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	59	6.49e-08	1.31e-06	0.41300	0.406000	7.54e-02	6.73e-08	3.16e-01
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	16	4.17e-03	2.75e-02	0.41200	0.412000	-1.01e-03	4.29e-03	9.94e-01
REACTOME ACTIVATION OF CASPASES THROUGH APOPTOSOME MEDIATED CLEAVAGE	5	8.20e-02	2.20e-01	0.41000	0.334000	-2.38e-01	1.96e-01	3.56e-01
REACTOME NEGATIVE REGULATION OF FLT3	15	7.21e-04	5.87e-03	0.41000	0.359000	-1.98e-01	1.59e-02	1.85e-01
REACTOME REGULATION OF NPAS4 GENE EXPRESSION	13	8.40e-02	2.24e-01	0.40800	0.200000	3.56e-01	2.11e-01	2.64e-02
REACTOME DERMATAN SULFATE BIOSYNTHESIS	10	1.43e-01	3.12e-01	0.40700	0.360000	1.91e-01	4.87e-02	2.96e-01
REACTOME BILE ACID AND BILE SALT METABOLISM	45	5.22e-04	4.47e-03	0.40500	-0.318000	-2.50e-01	2.19e-04	3.68e-03
REACTOME TRNA MODIFICATION IN THE MITOCHONDRION	7	1.35e-01	3.02e-01	0.40500	0.401000	5.33e-02	6.59e-02	8.07e-01
REACTOME MATURATION OF SARS COV 1 SPIKE PROTEIN	5	8.50e-02	2.25e-01	0.40400	0.266000	-3.05e-01	3.03e-01	2.38e-01
REACTOME RRNA PROCESSING IN THE MITOCHONDRION	6	3.69e-01	5.50e-01	0.40400	0.255000	3.13e-01	2.79e-01	1.84e-01
REACTOME ROLE OF ABL IN ROBO SLIT SIGNALING	8	2.71e-01	4.64e-01	0.40400	0.273000	2.97e-01	1.81e-01	1.45e-01
REACTOME SENSORY PERCEPTION OF TASTE	47	2.41e-09	8.22e-08	0.40200	-0.382000	1.26e-01	5.83e-06	1.36e-01
REACTOME PINK1 PRKN MEDIATED MITOPHAGY	20	5.84e-05	6.01e-04	0.40200	0.265000	-3.02e-01	3.98e-02	1.94e-02
REACTOME PI 3K CASCADE FGFR2	22	2.91e-02	1.11e-01	0.40200	0.283000	2.85e-01	2.15e-02	2.07e-02
REACTOME DEFECTIVE CSF2RB CAUSES SMDP5	7	3.10e-01	4.94e-01	0.40100	-0.321000	-2.40e-01	1.41e-01	2.71e-01
REACTOME BINDING OF TCF LEF CTNNB1 TO TARGET GENE PROMOTERS	8	2.68e-01	4.61e-01	0.40100	0.315000	2.49e-01	1.23e-01	2.23e-01
REACTOME REGULATION OF PTEN LOCALIZATION	8	3.37e-02	1.21e-01	0.40000	0.377000	-1.34e-01	6.48e-02	5.13e-01
REACTOME TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	5.39e-03	3.28e-02	0.40000	0.153000	-3.69e-01	3.59e-01	2.68e-02
REACTOME MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	12	3.17e-03	2.19e-02	0.39900	0.266000	-2.97e-01	1.11e-01	7.47e-02
REACTOME MULTIFUNCTIONAL ANION EXCHANGERS	9	2.36e-01	4.28e-01	0.39900	-0.259000	-3.03e-01	1.78e-01	1.16e-01
REACTOME MYOCLONIC EPILEPSY OF LAFORA	9	2.93e-02	1.11e-01	0.39800	0.387000	-9.36e-02	4.43e-02	6.27e-01
REACTOME PERK REGULATES GENE EXPRESSION	31	1.09e-06	1.59e-05	0.39800	0.360000	-1.70e-01	5.22e-04	1.01e-01
REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	2.20e-02	9.18e-02	0.39700	0.389000	7.85e-02	9.12e-03	5.99e-01
REACTOME RESPONSE TO METAL IONS	14	5.47e-02	1.68e-01	0.39600	0.369000	1.45e-01	1.68e-02	3.48e-01
REACTOME INTESTINAL ABSORPTION	5	2.03e-01	3.88e-01	0.39600	-0.396000	4.31e-03	1.25e-01	9.87e-01
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21	58	1.18e-12	6.67e-11	0.39600	0.293000	-2.67e-01	1.15e-04	4.32e-04
REACTOME NEGATIVE REGULATION OF FGFR1 SIGNALING	32	2.58e-03	1.80e-02	0.39600	0.353000	1.79e-01	5.55e-04	7.91e-02
REACTOME PLATELET CALCIUM HOMEOSTASIS	27	8.20e-03	4.50e-02	0.39500	0.195000	3.44e-01	7.89e-02	1.99e-03
REACTOME FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	16	2.13e-02	8.99e-02	0.39500	0.383000	9.33e-02	7.91e-03	5.18e-01
REACTOME ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES	17	3.96e-02	1.35e-01	0.39400	-0.356000	-1.70e-01	1.11e-02	2.25e-01
REACTOME INFLUENZA INFECTION	147	3.75e-27	4.73e-25	0.39400	0.139000	-3.68e-01	3.52e-03	1.25e-14
REACTOME RHOBTB3 ATPASE CYCLE	8	2.28e-01	4.19e-01	0.39300	0.177000	3.51e-01	3.87e-01	8.56e-02
REACTOME NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	3.75e-02	1.30e-01	0.39200	0.392000	-2.38e-02	3.20e-02	8.96e-01
REACTOME CS DS DEGRADATION	12	1.57e-01	3.30e-01	0.39100	0.295000	2.57e-01	7.71e-02	1.23e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	11	8.69e-02	2.29e-01	0.39100	0.374000	1.12e-01	3.15e-02	5.20e-01
REACTOME TRANSPORT OF FATTY ACIDS	8	1.22e-01	2.81e-01	0.39000	-0.386000	-5.44e-02	5.87e-02	7.90e-01
REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	18	5.90e-02	1.76e-01	0.38900	0.312000	2.32e-01	2.19e-02	8.82e-02
REACTOME TRANSLATION	261	1.04e-48	4.27e-46	0.38800	0.174000	-3.47e-01	1.21e-06	4.11e-22
REACTOME FRS MEDIATED FGFR2 SIGNALING	24	2.73e-02	1.06e-01	0.38800	0.280000	2.68e-01	1.75e-02	2.29e-02
REACTOME DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	39	2.28e-03	1.62e-02	0.38800	0.311000	2.32e-01	7.84e-04	1.22e-02
REACTOME ACYL CHAIN REMODELLING OF PG	18	5.35e-02	1.66e-01	0.38800	-0.325000	-2.12e-01	1.71e-02	1.20e-01
REACTOME REGULATION OF EXPRESSION OF SLITS AND ROBOS	158	1.46e-31	2.38e-29	0.38700	0.245000	-3.00e-01	1.02e-07	7.32e-11
REACTOME THYROXINE BIOSYNTHESIS	10	1.08e-01	2.61e-01	0.38700	0.105000	3.73e-01	5.67e-01	4.13e-02
REACTOME MAPK3 ERK1 ACTIVATION	10	2.19e-01	4.08e-01	0.38600	0.243000	3.00e-01	1.83e-01	1.00e-01
REACTOME MELANIN BIOSYNTHESIS	5	3.66e-01	5.46e-01	0.38600	-0.362000	-1.34e-01	1.61e-01	6.03e-01
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION OF UNSATURATED FATTY ACIDS	6	2.43e-01	4.35e-01	0.38500	0.376000	8.14e-02	1.10e-01	7.30e-01
REACTOME P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1	6	4.12e-01	5.87e-01	0.38500	0.279000	2.64e-01	2.36e-01	2.62e-01
REACTOME MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	17	8.14e-02	2.19e-01	0.38400	0.259000	2.83e-01	6.41e-02	4.32e-02
REACTOME TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	36	4.29e-03	2.79e-02	0.38300	0.304000	2.33e-01	1.57e-03	1.57e-02
REACTOME NEUROTRANSMITTER CLEARANCE	9	2.07e-01	3.92e-01	0.38200	0.172000	3.42e-01	3.72e-01	7.60e-02
REACTOME VITAMIN C ASCORBATE METABOLISM	8	2.76e-01	4.69e-01	0.38200	0.325000	2.02e-01	1.12e-01	3.23e-01
REACTOME RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	14	2.08e-03	1.49e-02	0.38200	0.260000	-2.80e-01	9.16e-02	7.00e-02
REACTOME SYNTHESIS OF 15 EICOSATETRAENOIC ACID DERIVATIVES	6	2.07e-01	3.92e-01	0.38200	0.380000	3.97e-02	1.07e-01	8.66e-01
REACTOME AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY	8	3.11e-01	4.94e-01	0.38100	0.254000	2.84e-01	2.13e-01	1.64e-01
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	12	2.10e-02	8.93e-02	0.38100	0.379000	-3.87e-02	2.29e-02	8.17e-01
REACTOME AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	53	8.31e-11	4.00e-09	0.38100	0.268000	-2.71e-01	7.45e-04	6.47e-04
REACTOME FATTY ACIDS	15	1.10e-01	2.63e-01	0.38100	-0.242000	-2.94e-01	1.05e-01	4.87e-02
REACTOME ACYL CHAIN REMODELLING OF PS	21	2.38e-02	9.72e-02	0.37900	-0.344000	-1.59e-01	6.32e-03	2.07e-01
REACTOME INTERLEUKIN 18 SIGNALING	8	3.09e-01	4.93e-01	0.37900	-0.297000	-2.35e-01	1.46e-01	2.50e-01
REACTOME IRAK1 RECRUITS IKK COMPLEX	12	1.23e-02	6.02e-02	0.37800	0.363000	-1.08e-01	2.96e-02	5.19e-01
REACTOME SCAVENGING OF HEME FROM PLASMA	13	1.08e-01	2.59e-01	0.37800	-0.338000	-1.69e-01	3.47e-02	2.91e-01
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	15	6.26e-02	1.84e-01	0.37800	0.144000	3.49e-01	3.34e-01	1.92e-02
REACTOME PREVENTION OF PHAGOSOMAL LYSOSOMAL FUSION	9	2.12e-02	8.99e-02	0.37700	0.241000	-2.90e-01	2.10e-01	1.32e-01
REACTOME CD163 MEDIATING AN ANTI INFLAMMATORY RESPONSE	9	2.64e-01	4.58e-01	0.37700	0.225000	3.03e-01	2.43e-01	1.15e-01
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	93	6.92e-07	1.07e-05	0.37700	0.314000	2.09e-01	1.64e-07	5.03e-04
REACTOME ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	27	4.34e-05	4.55e-04	0.37700	0.357000	-1.20e-01	1.31e-03	2.82e-01
REACTOME ACTIVATION OF C3 AND C5	6	9.74e-02	2.45e-01	0.37700	-0.347000	1.47e-01	1.41e-01	5.34e-01
REACTOME CHREBP ACTIVATES METABOLIC GENE EXPRESSION	8	2.55e-01	4.47e-01	0.37600	0.167000	3.38e-01	4.14e-01	9.83e-02
REACTOME ALPHA DEFENSINS	6	4.09e-01	5.84e-01	0.37500	-0.308000	-2.14e-01	1.91e-01	3.63e-01
REACTOME G2 PHASE	5	2.03e-01	3.88e-01	0.37500	0.371000	-4.93e-02	1.50e-01	8.49e-01
REACTOME POU5F1 OCT4 SOX2 NANOG ACTIVATE GENES RELATED TO PROLIFERATION	12	1.70e-01	3.49e-01	0.37400	0.217000	3.05e-01	1.94e-01	6.73e-02
REACTOME WNT LIGAND BIOGENESIS AND TRAFFICKING	25	1.56e-02	7.06e-02	0.37400	0.333000	1.70e-01	3.91e-03	1.41e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	31	1.25e-02	6.02e-02	0.37400	0.287000	2.40e-01	5.74e-03	2.06e-02
REACTOME SODIUM COUPLED SULPHATE DI AND TRI CARBOXYLATE TRANSPORTERS	5	4.69e-01	6.31e-01	0.37400	-0.313000	-2.04e-01	2.25e-01	4.30e-01
REACTOME NEUROTRANSMITTER RELEASE CYCLE	47	9.80e-04	7.86e-03	0.37300	0.307000	2.12e-01	2.75e-04	1.19e-02
REACTOME NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	24	3.60e-02	1.26e-01	0.37300	0.261000	2.66e-01	2.69e-02	2.39e-02
REACTOME MISCELLANEOUS SUBSTRATES	12	1.86e-01	3.68e-01	0.37300	-0.283000	-2.42e-01	8.94e-02	1.46e-01
REACTOME FGFR2 LIGAND BINDING AND ACTIVATION	19	6.54e-02	1.89e-01	0.37100	0.298000	2.21e-01	2.43e-02	9.55e-02
REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	10	1.07e-01	2.58e-01	0.37100	0.071800	3.64e-01	6.94e-01	4.63e-02
REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	11	2.20e-01	4.10e-01	0.36800	0.285000	2.33e-01	1.02e-01	1.81e-01
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	13	6.68e-03	3.86e-02	0.36700	0.323000	-1.75e-01	4.38e-02	2.75e-01
REACTOME PI 3K CASCADE FGFR3	17	1.01e-01	2.50e-01	0.36600	0.279000	2.37e-01	4.68e-02	9.05e-02
REACTOME INTERLEUKIN 7 SIGNALING	21	3.10e-02	1.14e-01	0.36500	0.332000	1.52e-01	8.50e-03	2.29e-01
REACTOME DEFECTIVE CHST3 CAUSES SEDCJD	7	3.95e-01	5.73e-01	0.36400	0.266000	2.49e-01	2.23e-01	2.53e-01
REACTOME ATORVASTATIN ADME	9	2.86e-01	4.77e-01	0.36400	-0.296000	-2.11e-01	1.24e-01	2.74e-01
REACTOME HDL ASSEMBLY	8	5.43e-02	1.67e-01	0.36300	-0.147000	3.32e-01	4.70e-01	1.04e-01
REACTOME LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	11	2.33e-01	4.26e-01	0.36300	0.273000	2.39e-01	1.17e-01	1.71e-01
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	14	1.07e-01	2.58e-01	0.36200	0.326000	1.57e-01	3.45e-02	3.09e-01
REACTOME GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	14	3.67e-02	1.28e-01	0.36200	0.360000	3.72e-02	1.97e-02	8.10e-01
REACTOME REGULATION OF KIT SIGNALING	16	1.22e-01	2.81e-01	0.36000	0.276000	2.32e-01	5.57e-02	1.09e-01
REACTOME NF KB IS ACTIVATED AND SIGNALS SURVIVAL	12	2.94e-02	1.11e-01	0.36000	0.357000	-4.56e-02	3.20e-02	7.85e-01
REACTOME SENSORY PERCEPTION OF SALTY TASTE	6	1.17e-01	2.73e-01	0.36000	-0.146000	3.29e-01	5.35e-01	1.63e-01
REACTOME SHC MEDIATED CASCADE FGFR3	17	1.06e-01	2.58e-01	0.36000	0.281000	2.25e-01	4.52e-02	1.08e-01
REACTOME ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY	5	1.89e-01	3.70e-01	0.35900	0.107000	-3.43e-01	6.78e-01	1.85e-01
REACTOME TRIF MEDIATED PROGRAMMED CELL DEATH	9	1.42e-01	3.11e-01	0.35900	0.354000	5.91e-02	6.58e-02	7.59e-01
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	16	1.10e-01	2.63e-01	0.35900	0.297000	2.00e-01	3.94e-02	1.65e-01
REACTOME LIPOPHAGY	9	2.86e-01	4.77e-01	0.35800	0.300000	1.95e-01	1.19e-01	3.10e-01
REACTOME DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	59	1.34e-10	6.25e-09	0.35800	0.266000	-2.39e-01	4.14e-04	1.47e-03
REACTOME SUMO IS CONJUGATED TO E1 UBA2 SAE1	5	2.56e-01	4.48e-01	0.35800	0.357000	-2.20e-02	1.67e-01	9.32e-01
REACTOME KERATAN SULFATE DEGRADATION	13	1.61e-01	3.34e-01	0.35700	-0.304000	-1.87e-01	5.79e-02	2.42e-01
REACTOME OAS ANTIVIRAL RESPONSE	7	1.22e-01	2.81e-01	0.35600	0.063800	-3.51e-01	7.70e-01	1.08e-01
REACTOME SUMOYLATION OF INTRACELLULAR RECEPTORS	29	2.21e-02	9.18e-02	0.35600	0.212000	2.85e-01	4.79e-02	7.81e-03
REACTOME SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA PHE	6	1.73e-01	3.52e-01	0.35500	0.054200	-3.51e-01	8.18e-01	1.37e-01
REACTOME RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA	5	2.48e-01	4.41e-01	0.35400	0.352000	-3.77e-02	1.73e-01	8.84e-01
REACTOME ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE	9	2.51e-01	4.43e-01	0.35400	-0.151000	-3.20e-01	4.34e-01	9.64e-02
REACTOME FRS MEDIATED FGFR3 SIGNALING	19	8.92e-02	2.32e-01	0.35300	0.275000	2.21e-01	3.77e-02	9.53e-02
REACTOME THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	27	3.28e-02	1.18e-01	0.35200	0.275000	2.21e-01	1.35e-02	4.72e-02
REACTOME KILLING MECHANISMS	11	2.36e-01	4.28e-01	0.35200	0.289000	2.01e-01	9.70e-02	2.48e-01
REACTOME VLDLR INTERNALISATION AND DEGRADATION	16	4.46e-02	1.44e-01	0.35100	0.342000	7.58e-02	1.78e-02	5.99e-01
REACTOME CELLULAR RESPONSE TO STARVATION	144	1.24e-22	1.12e-20	0.35000	0.168000	-3.07e-01	4.89e-04	1.86e-10
REACTOME HYDROLYSIS OF LPC	9	9.30e-02	2.38e-01	0.35000	-0.349000	2.51e-02	6.97e-02	8.96e-01
REACTOME G BETA GAMMA SIGNALLING THROUGH CDC42	19	6.97e-02	1.99e-01	0.34900	0.305000	1.69e-01	2.12e-02	2.02e-01
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	28	3.01e-02	1.12e-01	0.34900	0.276000	2.13e-01	1.15e-02	5.09e-02
REACTOME NEGATIVE REGULATION OF NOTCH4 SIGNALING	52	5.70e-09	1.70e-07	0.34800	0.260000	-2.32e-01	1.19e-03	3.84e-03
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH FYN	7	4.21e-01	5.90e-01	0.34800	0.272000	2.17e-01	2.13e-01	3.21e-01
REACTOME DISINHIBITION OF SNARE FORMATION	5	4.24e-01	5.92e-01	0.34700	0.331000	1.06e-01	2.00e-01	6.82e-01
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE FGFR4	14	1.82e-01	3.63e-01	0.34700	0.224000	2.65e-01	1.47e-01	8.57e-02
REACTOME CALNEXIN CALRETICULIN CYCLE	25	4.23e-04	3.76e-03	0.34700	0.331000	-1.03e-01	4.18e-03	3.71e-01
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	53	4.88e-09	1.53e-07	0.34600	0.263000	-2.25e-01	9.16e-04	4.52e-03
REACTOME RRNA PROCESSING	184	4.67e-27	5.45e-25	0.34600	0.140000	-3.17e-01	1.03e-03	1.21e-13
REACTOME TYPE I HEMIDESMOSOME ASSEMBLY	11	2.41e-01	4.33e-01	0.34600	-0.289000	-1.89e-01	9.67e-02	2.78e-01
REACTOME FREE FATTY ACIDS REGULATE INSULIN SECRETION	10	9.66e-02	2.44e-01	0.34500	-0.345000	-7.82e-03	5.90e-02	9.66e-01
REACTOME NEGATIVE REGULATION OF FGFR2 SIGNALING	33	9.95e-03	5.13e-02	0.34500	0.305000	1.60e-01	2.40e-03	1.11e-01
REACTOME RAB GERANYLGERANYLATION	57	1.07e-04	1.05e-03	0.34400	0.323000	1.18e-01	2.41e-05	1.22e-01
REACTOME ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS	7	3.91e-01	5.69e-01	0.34400	0.171000	2.98e-01	4.32e-01	1.72e-01
REACTOME MITOCHONDRIAL TRANSLATION	93	4.68e-15	3.65e-13	0.34400	0.222000	-2.62e-01	2.11e-04	1.23e-05
REACTOME LDL REMODELING	6	3.64e-01	5.44e-01	0.34300	-0.328000	-1.03e-01	1.65e-01	6.62e-01
REACTOME ER QUALITY CONTROL COMPARTMENT ERQC	20	5.31e-03	3.25e-02	0.34300	0.341000	-3.62e-02	8.20e-03	7.79e-01
REACTOME STABILIZATION OF P53	54	5.67e-09	1.70e-07	0.34300	0.271000	-2.10e-01	5.66e-04	7.54e-03
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	9	8.74e-02	2.29e-01	0.34200	0.051900	-3.38e-01	7.87e-01	7.90e-02
REACTOME NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	11	5.57e-02	1.70e-01	0.34200	0.340000	-3.99e-02	5.11e-02	8.19e-01
REACTOME REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	14	2.53e-02	1.01e-01	0.34200	0.040600	-3.39e-01	7.92e-01	2.79e-02
REACTOME ONCOGENE INDUCED SENESCENCE	35	1.57e-03	1.17e-02	0.34100	0.333000	7.27e-02	6.44e-04	4.57e-01
REACTOME FORMATION OF PARAXIAL MESODERM	21	8.82e-02	2.30e-01	0.34100	0.243000	2.39e-01	5.40e-02	5.81e-02
REACTOME TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	30	2.66e-02	1.04e-01	0.34000	0.275000	1.99e-01	9.06e-03	5.89e-02
REACTOME HORMONE LIGAND BINDING RECEPTORS	12	3.58e-02	1.26e-01	0.33900	-0.331000	7.03e-02	4.70e-02	6.73e-01
REACTOME G PROTEIN ACTIVATION	24	4.65e-02	1.48e-01	0.33800	0.290000	1.74e-01	1.38e-02	1.40e-01
REACTOME INTERLEUKIN 9 SIGNALING	7	2.75e-01	4.69e-01	0.33800	0.332000	6.81e-02	1.29e-01	7.55e-01
REACTOME SARS COV 1 HOST INTERACTIONS	88	1.03e-12	6.00e-11	0.33800	0.135000	-3.10e-01	2.84e-02	5.03e-07
REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	9	4.61e-02	1.47e-01	0.33600	-0.237000	2.39e-01	2.19e-01	2.14e-01
REACTOME NOSTRIN MEDIATED ENOS TRAFFICKING	5	5.46e-01	6.92e-01	0.33600	-0.188000	-2.78e-01	4.66e-01	2.81e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	29	3.62e-02	1.26e-01	0.33600	0.260000	2.13e-01	1.55e-02	4.73e-02
REACTOME DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1	9	4.80e-02	1.51e-01	0.33500	0.257000	-2.15e-01	1.82e-01	2.65e-01
REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	17	7.05e-03	4.03e-02	0.33400	0.318000	-1.04e-01	2.32e-02	4.60e-01
REACTOME NONCANONICAL ACTIVATION OF NOTCH3	8	1.68e-01	3.45e-01	0.33300	0.333000	-7.98e-04	1.03e-01	9.97e-01
REACTOME ACYL CHAIN REMODELLING OF PC	26	1.17e-02	5.85e-02	0.33200	-0.323000	-7.78e-02	4.34e-03	4.92e-01
REACTOME STAT5 ACTIVATION	7	1.18e-01	2.76e-01	0.33200	0.302000	-1.37e-01	1.66e-01	5.32e-01
REACTOME GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	35	9.47e-06	1.15e-04	0.33100	0.251000	-2.16e-01	1.01e-02	2.68e-02
REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	22	4.53e-03	2.92e-02	0.33100	0.329000	-3.76e-02	7.56e-03	7.60e-01
REACTOME PURINE CATABOLISM	17	1.30e-01	2.96e-01	0.33100	0.280000	1.77e-01	4.60e-02	2.06e-01
REACTOME FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	7.14e-02	2.01e-01	0.33100	0.324000	6.72e-02	2.98e-02	6.52e-01
REACTOME RIPK1 MEDIATED REGULATED NECROSIS	29	7.06e-05	7.22e-04	0.33000	0.239000	-2.28e-01	2.60e-02	3.34e-02
REACTOME OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS	8	3.20e-01	4.97e-01	0.33000	0.123000	3.06e-01	5.46e-01	1.34e-01
REACTOME P2Y RECEPTORS	9	3.22e-01	4.99e-01	0.33000	-0.290000	-1.58e-01	1.32e-01	4.13e-01
REACTOME CYTOSOLIC TRNA AMINOACYLATION	6	4.13e-01	5.87e-01	0.32900	-0.113000	-3.09e-01	6.31e-01	1.89e-01
REACTOME REGULATION BY C FLIP	11	3.25e-02	1.18e-01	0.32900	0.161000	-2.87e-01	3.55e-01	9.90e-02
REACTOME LRR FLII INTERACTING PROTEIN 1 LRRFIP1 ACTIVATES TYPE I IFN PRODUCTION	5	5.71e-01	7.15e-01	0.32900	0.197000	2.63e-01	4.45e-01	3.09e-01
REACTOME FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	31	3.41e-02	1.22e-01	0.32800	0.210000	2.52e-01	4.34e-02	1.51e-02
REACTOME FREE FATTY ACID RECEPTORS	5	4.58e-01	6.22e-01	0.32700	-0.314000	-9.28e-02	2.25e-01	7.19e-01
REACTOME ASYMMETRIC LOCALIZATION OF PCP PROTEINS	62	3.30e-08	7.49e-07	0.32700	0.311000	-1.01e-01	2.28e-05	1.69e-01
REACTOME BIOSYNTHESIS OF MARESINS	8	4.01e-01	5.78e-01	0.32600	-0.271000	-1.82e-01	1.85e-01	3.72e-01
REACTOME EARLY PHASE OF HIV LIFE CYCLE	14	4.03e-02	1.36e-01	0.32600	0.023700	-3.25e-01	8.78e-01	3.51e-02
REACTOME PHOSPHORYLATION OF EMI1	6	1.56e-01	3.28e-01	0.32600	0.275000	-1.74e-01	2.43e-01	4.62e-01
REACTOME NEGATIVE REGULATION OF FGFR3 SIGNALING	28	1.73e-02	7.75e-02	0.32500	0.306000	1.09e-01	5.00e-03	3.19e-01
REACTOME ACROSOME REACTION AND SPERM OOCYTE MEMBRANE BINDING	6	5.03e-01	6.60e-01	0.32500	-0.272000	-1.77e-01	2.48e-01	4.52e-01
REACTOME REGULATION OF NPAS4 GENE TRANSCRIPTION	5	2.85e-01	4.77e-01	0.32500	0.319000	-6.06e-02	2.17e-01	8.14e-01
REACTOME ACYL CHAIN REMODELLING OF PI	16	1.88e-01	3.70e-01	0.32300	-0.217000	-2.39e-01	1.34e-01	9.72e-02
REACTOME SMALL INTERFERING RNA SIRNA BIOGENESIS	9	3.89e-01	5.67e-01	0.32200	0.209000	2.46e-01	2.78e-01	2.02e-01
REACTOME CROSSLINKING OF COLLAGEN FIBRILS	16	1.46e-01	3.16e-01	0.32200	0.154000	2.83e-01	2.87e-01	4.99e-02
REACTOME ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION	9	1.07e-01	2.58e-01	0.32200	-0.316000	6.33e-02	1.01e-01	7.42e-01
REACTOME G1 S DNA DAMAGE CHECKPOINTS	65	2.21e-09	7.87e-08	0.32200	0.263000	-1.86e-01	2.46e-04	9.62e-03
REACTOME ROBO RECEPTORS BIND AKAP5	9	3.17e-01	4.95e-01	0.32100	0.135000	2.92e-01	4.84e-01	1.30e-01
REACTOME HEDGEHOG LIGAND BIOGENESIS	63	7.74e-09	2.18e-07	0.32100	0.278000	-1.61e-01	1.39e-04	2.75e-02
REACTOME REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	1.03e-07	1.89e-06	0.32000	0.259000	-1.88e-01	1.11e-03	1.80e-02
REACTOME METABOLISM OF POLYAMINES	55	4.97e-08	1.07e-06	0.31900	0.205000	-2.44e-01	8.42e-03	1.73e-03
REACTOME DRUG ADME	103	2.29e-05	2.55e-04	0.31800	-0.251000	-1.95e-01	1.04e-05	6.22e-04
REACTOME XENOBIOTICS	22	9.76e-02	2.45e-01	0.31800	-0.257000	-1.87e-01	3.68e-02	1.29e-01
REACTOME PHENYLALANINE METABOLISM	5	6.03e-01	7.38e-01	0.31800	0.231000	2.18e-01	3.70e-01	3.98e-01
REACTOME SPRY REGULATION OF FGF SIGNALING	16	1.88e-02	8.26e-02	0.31800	0.310000	-7.21e-02	3.20e-02	6.17e-01
REACTOME PRE NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM	6	1.65e-01	3.40e-01	0.31800	-0.187000	2.57e-01	4.27e-01	2.76e-01
REACTOME DEGRADATION OF AXIN	53	1.41e-07	2.53e-06	0.31700	0.256000	-1.86e-01	1.24e-03	1.93e-02
REACTOME SIGNALING BY WNT IN CANCER	32	4.12e-02	1.38e-01	0.31600	0.228000	2.19e-01	2.56e-02	3.18e-02
REACTOME CD28 CO STIMULATION	32	4.07e-02	1.36e-01	0.31600	0.210000	2.36e-01	4.00e-02	2.08e-02
REACTOME IRS MEDIATED SIGNALLING	47	7.84e-03	4.38e-02	0.31500	0.186000	2.54e-01	2.72e-02	2.62e-03
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	72	5.05e-10	2.07e-08	0.31500	0.240000	-2.03e-01	4.17e-04	2.90e-03
REACTOME SENSING OF DNA DOUBLE STRAND BREAKS	5	3.88e-01	5.66e-01	0.31500	-0.014700	-3.14e-01	9.55e-01	2.24e-01
REACTOME ACYL CHAIN REMODELLING OF PE	24	5.78e-02	1.75e-01	0.31300	-0.281000	-1.38e-01	1.70e-02	2.42e-01
REACTOME BETA OXIDATION OF OCTANOYL COA TO HEXANOYL COA	5	4.44e-01	6.11e-01	0.31300	0.308000	5.62e-02	2.33e-01	8.28e-01
REACTOME MITOCHONDRIAL PROTEIN IMPORT	54	1.45e-07	2.57e-06	0.31300	0.188000	-2.50e-01	1.70e-02	1.45e-03
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	45	1.72e-06	2.37e-05	0.31300	0.208000	-2.34e-01	1.59e-02	6.59e-03
REACTOME TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	17	1.05e-02	5.32e-02	0.31200	0.287000	-1.24e-01	4.07e-02	3.77e-01
REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	9	1.12e-01	2.66e-01	0.31200	0.302000	-7.80e-02	1.17e-01	6.85e-01
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	85	2.34e-11	1.23e-09	0.31100	0.252000	-1.84e-01	6.00e-05	3.44e-03
REACTOME EPHA MEDIATED GROWTH CONE COLLAPSE	29	5.82e-02	1.75e-01	0.31100	0.239000	2.00e-01	2.61e-02	6.23e-02
REACTOME POTASSIUM CHANNELS	102	5.47e-05	5.70e-04	0.31100	0.223000	2.17e-01	9.98e-05	1.50e-04
REACTOME NUCLEAR EVENTS MEDIATED BY NFE2L2	76	2.31e-09	8.05e-08	0.31100	0.289000	-1.16e-01	1.33e-05	8.15e-02
REACTOME DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	60	2.48e-08	6.12e-07	0.31100	0.225000	-2.14e-01	2.52e-03	4.09e-03
REACTOME ACTIVATION OF RAC1	11	2.26e-01	4.17e-01	0.31100	0.098200	2.95e-01	5.73e-01	9.06e-02
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	44	4.89e-03	3.07e-02	0.31100	0.284000	1.27e-01	1.13e-03	1.46e-01
REACTOME REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	71	6.02e-08	1.26e-06	0.31000	0.303000	-6.66e-02	9.88e-06	3.32e-01
REACTOME SCAVENGING BY CLASS A RECEPTORS	19	7.20e-02	2.02e-01	0.30900	-0.089700	-2.96e-01	4.99e-01	2.55e-02
REACTOME SIGNALING BY ERYTHROPOIETIN	25	7.15e-02	2.01e-01	0.30900	0.263000	1.62e-01	2.27e-02	1.61e-01
REACTOME P75NTR SIGNALS VIA NF KB	15	3.26e-02	1.18e-01	0.30900	0.303000	-5.94e-02	4.21e-02	6.91e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	34	3.71e-02	1.29e-01	0.30800	-0.241000	-1.92e-01	1.51e-02	5.23e-02
REACTOME CONDENSATION OF PROMETAPHASE CHROMOSOMES	11	4.53e-02	1.46e-01	0.30800	0.252000	-1.78e-01	1.49e-01	3.08e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS	9	1.24e-01	2.83e-01	0.30800	-0.068700	3.00e-01	7.21e-01	1.19e-01
REACTOME EGFR DOWNREGULATION	30	3.31e-02	1.19e-01	0.30800	0.275000	1.37e-01	9.04e-03	1.93e-01
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	16	1.63e-01	3.37e-01	0.30700	0.275000	1.37e-01	5.68e-02	3.42e-01
REACTOME GABA RECEPTOR ACTIVATION	57	4.46e-03	2.88e-02	0.30700	0.233000	2.00e-01	2.35e-03	8.91e-03
REACTOME COHESIN LOADING ONTO CHROMATIN	7	1.51e-01	3.23e-01	0.30600	-0.267000	1.50e-01	2.21e-01	4.92e-01
REACTOME POLO LIKE KINASE MEDIATED EVENTS	16	3.76e-02	1.30e-01	0.30600	0.305000	-2.75e-02	3.49e-02	8.49e-01
REACTOME TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	6.16e-03	3.61e-02	0.30600	0.217000	-2.16e-01	1.12e-01	1.13e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	24	1.45e-03	1.09e-02	0.30600	0.260000	-1.61e-01	2.76e-02	1.72e-01
REACTOME SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	7	1.50e-01	3.21e-01	0.30500	0.159000	-2.60e-01	4.66e-01	2.33e-01
REACTOME REPRESSION OF WNT TARGET GENES	13	2.87e-01	4.78e-01	0.30500	0.241000	1.87e-01	1.32e-01	2.43e-01
REACTOME 2 LTR CIRCLE FORMATION	7	1.69e-01	3.48e-01	0.30500	0.117000	-2.82e-01	5.92e-01	1.97e-01
REACTOME SIGNALING BY FGFR1	49	3.63e-03	2.43e-02	0.30500	0.276000	1.28e-01	8.12e-04	1.21e-01
REACTOME FRUCTOSE METABOLISM	7	5.22e-01	6.77e-01	0.30400	-0.224000	-2.06e-01	3.05e-01	3.45e-01
REACTOME CELLULAR RESPONSE TO HYPOXIA	71	2.25e-08	5.74e-07	0.30400	0.284000	-1.08e-01	3.40e-05	1.15e-01
REACTOME ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	1.29e-02	6.15e-02	0.30400	0.277000	-1.25e-01	4.77e-02	3.73e-01
REACTOME APEX1 INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	7	5.26e-01	6.80e-01	0.30300	0.215000	2.15e-01	3.25e-01	3.26e-01
REACTOME ERKS ARE INACTIVATED	13	7.86e-02	2.14e-01	0.30300	0.303000	-1.73e-02	5.86e-02	9.14e-01
REACTOME RUNX3 REGULATES WNT SIGNALING	8	4.27e-01	5.94e-01	0.30300	0.266000	1.46e-01	1.93e-01	4.76e-01
REACTOME APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	86	5.82e-11	2.88e-09	0.30300	0.239000	-1.86e-01	1.26e-04	2.84e-03
REACTOME DEGRADATION OF GLI1 BY THE PROTEASOME	58	1.79e-07	3.14e-06	0.30300	0.255000	-1.63e-01	7.92e-04	3.14e-02
REACTOME ACTIVATION OF SMO	17	1.85e-01	3.68e-01	0.30200	0.254000	1.62e-01	6.97e-02	2.46e-01
REACTOME UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	19	1.80e-01	3.60e-01	0.30100	0.209000	2.17e-01	1.15e-01	1.02e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	24	9.63e-02	2.44e-01	0.30000	0.251000	1.64e-01	3.30e-02	1.65e-01
REACTOME FGFR1 MUTANT RECEPTOR ACTIVATION	30	6.83e-02	1.95e-01	0.30000	0.212000	2.12e-01	4.46e-02	4.44e-02
REACTOME TLR3 MEDIATED TICAM1 DEPENDENT PROGRAMMED CELL DEATH	6	2.26e-01	4.17e-01	0.29900	0.122000	-2.73e-01	6.04e-01	2.46e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS	9	2.07e-01	3.92e-01	0.29900	-0.299000	-8.43e-03	1.20e-01	9.65e-01
REACTOME INTERLEUKIN 6 SIGNALING	11	3.54e-01	5.35e-01	0.29900	0.244000	1.73e-01	1.61e-01	3.20e-01
REACTOME PASSIVE TRANSPORT BY AQUAPORINS	13	3.09e-01	4.93e-01	0.29900	-0.228000	-1.93e-01	1.54e-01	2.28e-01
REACTOME SPERM MOTILITY AND TAXES	9	4.14e-01	5.88e-01	0.29900	-0.253000	-1.59e-01	1.89e-01	4.09e-01
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	36	7.74e-04	6.26e-03	0.29800	0.296000	-3.43e-02	2.10e-03	7.22e-01
REACTOME TRANSLESION SYNTHESIS BY POLH	18	1.96e-02	8.53e-02	0.29800	0.290000	-6.77e-02	3.30e-02	6.19e-01
REACTOME REGULATION OF TLR BY ENDOGENOUS LIGAND	20	1.48e-01	3.20e-01	0.29800	-0.164000	-2.48e-01	2.04e-01	5.46e-02
REACTOME NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	20	1.70e-01	3.49e-01	0.29700	0.201000	2.19e-01	1.19e-01	8.99e-02
REACTOME STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS	10	9.36e-02	2.38e-01	0.29700	0.278000	-1.05e-01	1.28e-01	5.66e-01
REACTOME RUNX3 REGULATES NOTCH SIGNALING	13	3.10e-01	4.94e-01	0.29700	0.233000	1.84e-01	1.46e-01	2.52e-01
REACTOME G2 M DNA REPLICATION CHECKPOINT	5	2.67e-01	4.61e-01	0.29600	0.200000	-2.18e-01	4.38e-01	3.99e-01
REACTOME TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	10	7.11e-02	2.01e-01	0.29600	0.216000	-2.02e-01	2.37e-01	2.68e-01
REACTOME VEGFR2 MEDIATED CELL PROLIFERATION	19	1.80e-01	3.60e-01	0.29600	0.178000	2.36e-01	1.78e-01	7.53e-02
REACTOME DEGRADATION OF DVL	55	5.60e-07	8.99e-06	0.29600	0.230000	-1.86e-01	3.18e-03	1.72e-02
REACTOME N GLYCAN ANTENNAE ELONGATION	15	2.71e-01	4.64e-01	0.29500	0.203000	2.15e-01	1.74e-01	1.49e-01
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	26	3.40e-02	1.21e-01	0.29500	-0.285000	-7.82e-02	1.19e-02	4.90e-01
REACTOME HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS	7	4.36e-01	6.03e-01	0.29500	0.277000	1.01e-01	2.04e-01	6.44e-01
REACTOME IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	3.62e-01	5.43e-01	0.29500	-0.168000	-2.43e-01	3.35e-01	1.64e-01
REACTOME G ALPHA Z SIGNALLING EVENTS	48	1.43e-02	6.66e-02	0.29500	0.229000	1.85e-01	5.99e-03	2.62e-02
REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	19	1.75e-01	3.54e-01	0.29500	0.241000	1.70e-01	6.91e-02	2.00e-01
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	14	2.99e-01	4.89e-01	0.29400	0.212000	2.04e-01	1.69e-01	1.87e-01
REACTOME SIGNALING BY ROBO RECEPTORS	202	1.62e-23	1.56e-21	0.29400	0.205000	-2.11e-01	4.86e-07	2.42e-07
REACTOME ORGANIC ANION TRANSPORTERS	10	4.21e-01	5.90e-01	0.29400	0.198000	2.17e-01	2.78e-01	2.34e-01
REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	7	2.11e-01	3.98e-01	0.29300	0.086900	-2.80e-01	6.91e-01	1.99e-01
REACTOME RAS PROCESSING	22	7.70e-03	4.33e-02	0.29300	0.281000	-8.48e-02	2.25e-02	4.91e-01
REACTOME CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	13	3.46e-02	1.23e-01	0.29300	0.197000	-2.16e-01	2.18e-01	1.77e-01
REACTOME MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	15	8.48e-02	2.25e-01	0.29200	0.292000	1.23e-02	5.01e-02	9.34e-01
REACTOME SYNTHESIS OF DOLICHYL PHOSPHATE	6	5.13e-01	6.70e-01	0.29200	0.271000	1.09e-01	2.51e-01	6.44e-01
REACTOME SULFIDE OXIDATION TO SULFATE	5	5.94e-01	7.33e-01	0.29200	0.125000	2.63e-01	6.28e-01	3.08e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING	6	6.02e-01	7.37e-01	0.29100	0.199000	2.13e-01	3.99e-01	3.67e-01
REACTOME PLASMA LIPOPROTEIN REMODELING	32	1.99e-02	8.59e-02	0.29100	-0.278000	-8.45e-02	6.41e-03	4.08e-01
REACTOME RAS SIGNALING DOWNSTREAM OF NF1 LOSS OF FUNCTION VARIANTS	7	4.82e-01	6.42e-01	0.29100	0.263000	1.23e-01	2.28e-01	5.72e-01
REACTOME KSRP KHSRP BINDS AND DESTABILIZES MRNA	17	1.86e-02	8.18e-02	0.29100	0.265000	-1.20e-01	5.89e-02	3.90e-01
REACTOME PROLONGED ERK ACTIVATION EVENTS	14	3.07e-01	4.92e-01	0.29000	0.196000	2.14e-01	2.04e-01	1.66e-01
REACTOME SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	51	2.05e-04	1.95e-03	0.29000	0.290000	4.52e-03	3.34e-04	9.55e-01
REACTOME SYNTHESIS OF PI	5	4.21e-01	5.90e-01	0.29000	-0.006480	2.90e-01	9.80e-01	2.61e-01
REACTOME REGULATION OF RAS BY GAPS	65	9.48e-08	1.76e-06	0.29000	0.235000	-1.69e-01	1.03e-03	1.84e-02
REACTOME TACHYKININ RECEPTORS BIND TACHYKININS	5	6.58e-01	7.79e-01	0.29000	0.206000	2.04e-01	4.25e-01	4.30e-01
REACTOME GLUCONEOGENESIS	32	2.35e-02	9.62e-02	0.28900	-0.091500	-2.74e-01	3.70e-01	7.22e-03
REACTOME REGULATION OF SIGNALING BY CBL	22	1.31e-02	6.19e-02	0.28900	0.284000	-5.11e-02	2.09e-02	6.78e-01
REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	10	3.66e-01	5.46e-01	0.28900	0.128000	2.59e-01	4.84e-01	1.56e-01
REACTOME INLA MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS	9	1.72e-01	3.50e-01	0.28900	0.284000	-4.88e-02	1.39e-01	8.00e-01
REACTOME SIGNALING BY NODAL	21	1.74e-01	3.52e-01	0.28800	0.211000	1.96e-01	9.35e-02	1.19e-01
REACTOME CARNITINE METABOLISM	13	2.06e-01	3.91e-01	0.28800	0.079400	2.76e-01	6.20e-01	8.45e-02
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	34	4.00e-04	3.58e-03	0.28800	0.261000	-1.21e-01	8.53e-03	2.20e-01
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	24	8.10e-02	2.18e-01	0.28700	0.264000	1.15e-01	2.54e-02	3.30e-01
REACTOME METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	15	2.92e-01	4.83e-01	0.28700	-0.203000	-2.03e-01	1.73e-01	1.74e-01
REACTOME PARACETAMOL ADME	26	6.20e-02	1.84e-01	0.28700	-0.266000	-1.09e-01	1.91e-02	3.37e-01
REACTOME BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	42	2.76e-02	1.07e-01	0.28700	-0.171000	-2.30e-01	5.47e-02	9.82e-03
REACTOME SCAVENGING BY CLASS F RECEPTORS	6	2.26e-01	4.17e-01	0.28700	0.190000	-2.15e-01	4.20e-01	3.62e-01
REACTOME SIGNALING BY NTRKS	132	3.12e-07	5.31e-06	0.28600	0.271000	9.15e-02	7.65e-08	6.94e-02
REACTOME RNA POLYMERASE III CHAIN ELONGATION	18	1.21e-02	5.98e-02	0.28500	0.196000	-2.07e-01	1.50e-01	1.29e-01
REACTOME RNA POLYMERASE I PROMOTER ESCAPE	27	1.41e-03	1.06e-02	0.28500	0.223000	-1.77e-01	4.49e-02	1.11e-01
REACTOME MAPK6 MAPK4 SIGNALING	89	7.19e-08	1.43e-06	0.28500	0.282000	-3.93e-02	4.24e-06	5.22e-01
REACTOME CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	16	2.47e-02	9.93e-02	0.28400	0.250000	-1.35e-01	8.32e-02	3.48e-01
REACTOME CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	83	2.82e-09	9.42e-08	0.28400	0.236000	-1.58e-01	1.95e-04	1.31e-02
REACTOME REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	6.27e-02	1.84e-01	0.28400	0.283000	1.37e-02	3.74e-02	9.20e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	67	6.81e-07	1.06e-05	0.28300	0.267000	-9.40e-02	1.54e-04	1.83e-01
REACTOME BETA OXIDATION OF BUTANOYL COA TO ACETYL COA	5	4.23e-01	5.91e-01	0.28300	-0.283000	1.89e-02	2.74e-01	9.42e-01
REACTOME UCH PROTEINASES	81	1.59e-08	4.20e-07	0.28300	0.257000	-1.18e-01	6.19e-05	6.73e-02
REACTOME NEPHRIN FAMILY INTERACTIONS	21	1.74e-01	3.52e-01	0.28200	0.166000	2.28e-01	1.88e-01	7.03e-02
REACTOME SIGNALING BY LEPTIN	11	3.28e-01	5.07e-01	0.28100	0.259000	1.10e-01	1.37e-01	5.27e-01
REACTOME UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES	9	1.17e-01	2.73e-01	0.28100	-0.189000	2.08e-01	3.25e-01	2.80e-01
REACTOME GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	42	3.62e-02	1.26e-01	0.28100	0.208000	1.89e-01	1.95e-02	3.42e-02
REACTOME SIGNALING BY NOTCH4	79	8.23e-08	1.60e-06	0.28100	0.266000	-8.98e-02	4.31e-05	1.67e-01
REACTOME ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA	5	6.73e-01	7.91e-01	0.28100	0.210000	1.86e-01	4.15e-01	4.71e-01
REACTOME VISUAL PHOTOTRANSDUCTION	93	8.71e-05	8.69e-04	0.28000	-0.258000	-1.09e-01	1.67e-05	6.95e-02
REACTOME DECTIN 2 FAMILY	26	1.25e-01	2.86e-01	0.28000	-0.219000	-1.75e-01	5.36e-02	1.23e-01
REACTOME INTERLEUKIN 6 FAMILY SIGNALING	24	9.83e-02	2.46e-01	0.27900	0.254000	1.15e-01	3.15e-02	3.27e-01
REACTOME SIGNALING BY NTRK2 TRKB	25	4.39e-02	1.44e-01	0.27800	0.273000	5.57e-02	1.82e-02	6.30e-01
REACTOME REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	9	4.08e-01	5.83e-01	0.27800	0.257000	1.07e-01	1.83e-01	5.77e-01
REACTOME FATTY ACIDS BOUND TO GPR40 FFAR1 REGULATE INSULIN SECRETION	8	2.87e-01	4.78e-01	0.27800	-0.278000	1.47e-03	1.74e-01	9.94e-01
REACTOME THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	76	2.54e-08	6.12e-07	0.27800	0.219000	-1.70e-01	9.54e-04	1.02e-02
REACTOME LTC4 CYSLTR MEDIATED IL4 PRODUCTION	6	3.22e-01	4.99e-01	0.27700	-0.270000	6.26e-02	2.52e-01	7.91e-01
REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	15	9.71e-02	2.45e-01	0.27700	-0.277000	1.50e-03	6.29e-02	9.92e-01
REACTOME DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS	25	3.34e-03	2.27e-02	0.27700	0.226000	-1.61e-01	5.05e-02	1.64e-01
REACTOME RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	29	1.48e-02	6.82e-02	0.27700	0.276000	1.55e-02	9.97e-03	8.85e-01
REACTOME SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	27	5.50e-03	3.29e-02	0.27700	0.267000	-7.17e-02	1.62e-02	5.19e-01
REACTOME REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS	7	5.86e-01	7.25e-01	0.27700	0.190000	2.01e-01	3.83e-01	3.57e-01
REACTOME MITOPHAGY	26	2.55e-03	1.79e-02	0.27700	0.214000	-1.75e-01	5.89e-02	1.22e-01
REACTOME FLT3 SIGNALING	38	3.64e-03	2.43e-02	0.27600	0.276000	9.60e-03	3.23e-03	9.18e-01
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	25	1.46e-01	3.16e-01	0.27600	0.178000	2.11e-01	1.22e-01	6.81e-02
REACTOME RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	37	1.31e-02	6.19e-02	0.27600	0.066100	2.68e-01	4.87e-01	4.76e-03
REACTOME TRANSLESION SYNTHESIS BY POLK	17	6.02e-02	1.79e-01	0.27500	0.274000	-2.34e-02	5.02e-02	8.67e-01
REACTOME ARMS MEDIATED ACTIVATION	7	5.83e-01	7.24e-01	0.27500	0.174000	2.13e-01	4.25e-01	3.29e-01
REACTOME RESPIRATORY ELECTRON TRANSPORT	90	5.93e-09	1.73e-07	0.27500	0.117000	-2.49e-01	5.57e-02	4.37e-05
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	17	2.60e-02	1.03e-01	0.27500	0.127000	-2.44e-01	3.65e-01	8.15e-02
REACTOME REGULATION OF MECP2 EXPRESSION AND ACTIVITY	30	6.38e-02	1.86e-01	0.27400	0.118000	2.47e-01	2.62e-01	1.90e-02
REACTOME METABOLISM OF PORPHYRINS	26	1.18e-01	2.76e-01	0.27400	-0.147000	-2.31e-01	1.95e-01	4.11e-02
REACTOME CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	10	2.09e-01	3.95e-01	0.27400	0.273000	-1.12e-02	1.34e-01	9.51e-01
REACTOME CLEC7A INFLAMMASOME PATHWAY	6	4.84e-01	6.43e-01	0.27400	0.268000	5.41e-02	2.55e-01	8.19e-01
REACTOME NEURONAL SYSTEM	387	4.39e-13	3.12e-11	0.27300	0.183000	2.02e-01	5.73e-10	8.09e-12
REACTOME IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN	5	6.78e-01	7.96e-01	0.27200	-0.160000	-2.20e-01	5.35e-01	3.94e-01
REACTOME METABOLISM OF STEROID HORMONES	33	8.75e-02	2.29e-01	0.27200	-0.189000	-1.96e-01	6.03e-02	5.14e-02
REACTOME CYCLIN D ASSOCIATED EVENTS IN G1	46	5.53e-05	5.72e-04	0.27200	0.236000	-1.35e-01	5.59e-03	1.13e-01
REACTOME AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	9	1.61e-01	3.34e-01	0.27200	-0.250000	1.07e-01	1.94e-01	5.78e-01
REACTOME RNA POLYMERASE II TRANSCRIPTION	1262	1.45e-49	7.90e-47	0.27200	0.249000	1.10e-01	1.42e-50	4.93e-11
REACTOME NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	19	2.40e-01	4.31e-01	0.27200	0.172000	2.11e-01	1.95e-01	1.12e-01
REACTOME INTERLEUKIN RECEPTOR SHC SIGNALING	24	1.65e-01	3.41e-01	0.27200	-0.210000	-1.72e-01	7.47e-02	1.44e-01
REACTOME PLASMA LIPOPROTEIN ASSEMBLY	19	1.46e-01	3.16e-01	0.27200	-0.256000	-9.04e-02	5.31e-02	4.95e-01
REACTOME DNA DAMAGE RECOGNITION IN GG NER	36	1.93e-03	1.40e-02	0.27100	0.267000	-4.76e-02	5.52e-03	6.21e-01
REACTOME SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	52	2.00e-02	8.59e-02	0.27100	0.168000	2.13e-01	3.55e-02	7.95e-03
REACTOME TRANSCRIPTIONAL REGULATION BY VENTX	41	4.72e-02	1.50e-01	0.27100	0.174000	2.08e-01	5.36e-02	2.12e-02
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	20	2.23e-01	4.13e-01	0.27100	0.212000	1.70e-01	1.01e-01	1.89e-01
REACTOME INTEGRATION OF PROVIRUS	9	1.90e-01	3.73e-01	0.27100	0.068800	-2.62e-01	7.21e-01	1.73e-01
REACTOME ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	87	1.76e-03	1.31e-02	0.27100	0.191000	1.92e-01	2.05e-03	1.98e-03
REACTOME DEFENSINS	33	8.99e-02	2.33e-01	0.27000	-0.198000	-1.84e-01	4.88e-02	6.74e-02
REACTOME RNA POLYMERASE I TRANSCRIPTION TERMINATION	26	3.77e-03	2.50e-02	0.27000	0.225000	-1.49e-01	4.69e-02	1.88e-01
REACTOME CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	2.18e-02	9.15e-02	0.27000	0.247000	-1.10e-01	6.25e-02	4.08e-01
REACTOME EPH EPHRIN MEDIATED REPULSION OF CELLS	50	1.73e-02	7.75e-02	0.27000	0.231000	1.38e-01	4.65e-03	9.02e-02
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	14	9.09e-02	2.35e-01	0.26900	0.265000	-4.82e-02	8.64e-02	7.55e-01
REACTOME NEUREXINS AND NEUROLIGINS	51	2.55e-02	1.02e-01	0.26800	0.182000	1.98e-01	2.48e-02	1.46e-02
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	10	1.14e-01	2.69e-01	0.26800	0.177000	-2.01e-01	3.31e-01	2.70e-01
REACTOME NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER	18	2.08e-02	8.86e-02	0.26800	0.213000	-1.63e-01	1.18e-01	2.30e-01
REACTOME FLT3 SIGNALING IN DISEASE	28	1.39e-02	6.51e-02	0.26800	0.268000	-1.52e-02	1.41e-02	8.89e-01
REACTOME SIGNALING BY FGFR1 IN DISEASE	37	7.01e-02	1.99e-01	0.26800	0.181000	1.97e-01	5.62e-02	3.77e-02
REACTOME SIGNALING BY SCF KIT	42	2.93e-02	1.11e-01	0.26800	0.237000	1.25e-01	7.89e-03	1.60e-01
REACTOME PI3K AKT ACTIVATION	9	5.23e-01	6.77e-01	0.26800	0.178000	2.00e-01	3.54e-01	2.99e-01
REACTOME TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	16	3.33e-02	1.19e-01	0.26800	0.217000	-1.56e-01	1.32e-01	2.80e-01
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	29	7.10e-02	2.01e-01	0.26700	0.246000	1.05e-01	2.20e-02	3.28e-01
REACTOME PYRIMIDINE SALVAGE	10	3.44e-01	5.24e-01	0.26700	-0.069800	-2.58e-01	7.02e-01	1.58e-01
REACTOME TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	167	2.16e-07	3.73e-06	0.26700	0.247000	1.01e-01	3.64e-08	2.41e-02
REACTOME MUCOPOLYSACCHARIDOSES	10	4.07e-01	5.83e-01	0.26700	0.107000	2.44e-01	5.57e-01	1.81e-01
REACTOME MET ACTIVATES PTPN11	5	5.55e-01	6.99e-01	0.26600	-0.046500	-2.62e-01	8.57e-01	3.10e-01
REACTOME SIGNALING BY PDGFR IN DISEASE	20	2.47e-01	4.40e-01	0.26500	0.187000	1.88e-01	1.47e-01	1.46e-01
REACTOME IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	17	3.04e-01	4.91e-01	0.26500	0.195000	1.79e-01	1.64e-01	2.01e-01
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM	50	2.86e-02	1.10e-01	0.26400	0.166000	2.05e-01	4.19e-02	1.20e-02
REACTOME PP2A MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS	6	3.12e-01	4.94e-01	0.26400	0.240000	-1.11e-01	3.09e-01	6.39e-01
REACTOME DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	81	4.37e-07	7.15e-06	0.26400	0.252000	-8.04e-02	9.00e-05	2.11e-01
REACTOME BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	17	3.20e-02	1.17e-01	0.26400	0.226000	-1.36e-01	1.06e-01	3.31e-01
REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	1.35e-01	3.02e-01	0.26400	0.241000	1.09e-01	4.58e-02	3.67e-01
REACTOME RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION	8	1.99e-01	3.83e-01	0.26400	-0.227000	1.35e-01	2.67e-01	5.09e-01
REACTOME N GLYCAN TRIMMING AND ELONGATION IN THE CIS GOLGI	5	7.04e-01	8.10e-01	0.26400	0.200000	1.72e-01	4.38e-01	5.07e-01
REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	16	3.06e-01	4.92e-01	0.26400	0.217000	1.49e-01	1.32e-01	3.03e-01
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	95	5.58e-09	1.70e-07	0.26300	0.132000	-2.28e-01	2.60e-02	1.22e-04
REACTOME GLYCOGEN SYNTHESIS	13	1.94e-01	3.75e-01	0.26300	0.262000	2.49e-02	1.02e-01	8.76e-01
REACTOME G0 AND EARLY G1	27	1.92e-02	8.38e-02	0.26300	0.263000	-1.37e-02	1.80e-02	9.02e-01
REACTOME SARS COV 1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES	36	6.03e-04	5.11e-03	0.26300	0.155000	-2.13e-01	1.08e-01	2.71e-02
REACTOME FCGR ACTIVATION	11	3.78e-01	5.58e-01	0.26300	0.242000	1.03e-01	1.65e-01	5.53e-01
REACTOME SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	17	2.72e-01	4.64e-01	0.26200	0.135000	2.25e-01	3.34e-01	1.09e-01
REACTOME ALPHA OXIDATION OF PHYTANATE	6	3.23e-01	5.00e-01	0.26200	0.104000	-2.40e-01	6.60e-01	3.08e-01
REACTOME CGMP EFFECTS	15	3.37e-01	5.18e-01	0.26200	-0.150000	-2.14e-01	3.13e-01	1.51e-01
REACTOME ENOS ACTIVATION	11	3.98e-01	5.75e-01	0.26200	0.236000	1.13e-01	1.75e-01	5.18e-01
REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	8	2.47e-01	4.40e-01	0.26100	-0.251000	7.33e-02	2.19e-01	7.20e-01
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	254	4.01e-08	8.99e-07	0.26100	0.186000	1.83e-01	3.46e-07	5.05e-07
REACTOME DEFECTIVE LFNG CAUSES SCDO3	5	4.61e-01	6.23e-01	0.26000	-0.035400	2.58e-01	8.91e-01	3.18e-01
REACTOME TNFR2 NON CANONICAL NF KB PATHWAY	95	1.07e-08	2.91e-07	0.26000	0.229000	-1.24e-01	1.15e-04	3.65e-02
REACTOME ORC1 REMOVAL FROM CHROMATIN	69	7.78e-07	1.18e-05	0.26000	0.193000	-1.74e-01	5.54e-03	1.22e-02
REACTOME LONG TERM POTENTIATION	22	2.27e-01	4.17e-01	0.26000	0.183000	1.85e-01	1.37e-01	1.33e-01
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	97	4.03e-09	1.29e-07	0.25900	0.153000	-2.09e-01	9.07e-03	3.74e-04
REACTOME APOPTOTIC FACTOR MEDIATED RESPONSE	17	7.83e-02	2.14e-01	0.25900	0.257000	-2.88e-02	6.61e-02	8.37e-01
REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	20	1.20e-01	2.78e-01	0.25900	0.253000	5.53e-02	5.04e-02	6.69e-01
REACTOME ERBB2 REGULATES CELL MOTILITY	15	3.39e-01	5.19e-01	0.25900	0.216000	1.43e-01	1.48e-01	3.39e-01
REACTOME REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	4.75e-01	6.36e-01	0.25900	0.133000	2.21e-01	4.65e-01	2.25e-01
REACTOME HUR ELAVL1 BINDS AND STABILIZES MRNA	8	5.75e-01	7.18e-01	0.25800	0.154000	2.07e-01	4.50e-01	3.11e-01
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	53	2.71e-02	1.06e-01	0.25800	0.159000	2.03e-01	4.48e-02	1.07e-02
REACTOME SIGNALING BY FGFR3	39	2.18e-02	9.15e-02	0.25800	0.248000	7.00e-02	7.38e-03	4.49e-01
REACTOME MYOGENESIS	29	1.14e-01	2.70e-01	0.25800	0.130000	2.22e-01	2.26e-01	3.81e-02
REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	18	2.32e-01	4.25e-01	0.25700	0.110000	2.32e-01	4.18e-01	8.77e-02
REACTOME NEGATIVE REGULATION OF FGFR4 SIGNALING	30	5.68e-02	1.73e-01	0.25700	0.246000	7.38e-02	1.98e-02	4.84e-01
REACTOME RMTS METHYLATE HISTONE ARGININES	29	1.41e-01	3.10e-01	0.25600	0.203000	1.56e-01	5.84e-02	1.46e-01
REACTOME SIGNALING BY ERBB2 IN CANCER	25	8.02e-02	2.18e-01	0.25600	0.248000	6.02e-02	3.16e-02	6.02e-01
REACTOME ASSEMBLY OF THE HIV VIRION	16	1.22e-01	2.81e-01	0.25500	0.255000	-7.07e-04	7.69e-02	9.96e-01
REACTOME INTERLEUKIN 12 SIGNALING	43	2.36e-04	2.22e-03	0.25500	0.204000	-1.53e-01	2.04e-02	8.25e-02
REACTOME SHC1 EVENTS IN ERBB2 SIGNALING	22	1.73e-01	3.52e-01	0.25500	0.230000	1.08e-01	6.13e-02	3.79e-01
REACTOME MAPK1 ERK2 ACTIVATION	9	4.88e-01	6.47e-01	0.25400	0.107000	2.30e-01	5.77e-01	2.31e-01
REACTOME ABC TRANSPORTER DISORDERS	75	5.36e-07	8.67e-06	0.25400	0.154000	-2.02e-01	2.09e-02	2.48e-03
REACTOME ETHANOL OXIDATION	12	4.55e-01	6.18e-01	0.25400	-0.197000	-1.60e-01	2.36e-01	3.39e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS	7	6.21e-01	7.52e-01	0.25300	0.143000	2.08e-01	5.13e-01	3.40e-01
REACTOME DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	30	1.30e-01	2.94e-01	0.25300	0.209000	1.42e-01	4.75e-02	1.78e-01
REACTOME CARGO CONCENTRATION IN THE ER	32	6.65e-02	1.92e-01	0.25300	-0.090900	-2.36e-01	3.73e-01	2.11e-02
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	26	7.07e-03	4.03e-02	0.25200	0.195000	-1.59e-01	8.49e-02	1.60e-01
REACTOME RUNX3 REGULATES P14 ARF	10	4.18e-01	5.90e-01	0.25200	0.238000	8.33e-02	1.93e-01	6.48e-01
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	15	2.93e-01	4.84e-01	0.25100	-0.232000	-9.62e-02	1.19e-01	5.19e-01
REACTOME VLDL CLEARANCE	6	6.08e-01	7.41e-01	0.25100	0.233000	9.25e-02	3.22e-01	6.95e-01
REACTOME RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	9.35e-02	2.38e-01	0.25100	0.157000	1.95e-01	9.76e-02	3.99e-02
REACTOME PI 3K CASCADE FGFR4	19	3.02e-01	4.90e-01	0.25100	0.186000	1.68e-01	1.61e-01	2.04e-01
REACTOME REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	2.81e-01	4.74e-01	0.25100	0.114000	2.23e-01	4.16e-01	1.11e-01
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	32	1.36e-01	3.02e-01	0.25000	0.176000	1.78e-01	8.52e-02	8.10e-02
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	78	7.85e-07	1.18e-05	0.25000	0.217000	-1.24e-01	9.05e-04	5.77e-02
REACTOME FRS MEDIATED FGFR4 SIGNALING	21	2.65e-01	4.59e-01	0.25000	0.192000	1.60e-01	1.28e-01	2.03e-01
REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	4.18e-01	5.90e-01	0.25000	0.220000	1.18e-01	1.87e-01	4.79e-01
REACTOME PCP CE PATHWAY	90	3.34e-06	4.41e-05	0.25000	0.248000	-3.04e-02	4.83e-05	6.18e-01
REACTOME HEDGEHOG ON STATE	83	3.75e-06	4.86e-05	0.24900	0.243000	-5.39e-02	1.30e-04	3.96e-01
REACTOME PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING	5	4.75e-01	6.36e-01	0.24900	0.049400	-2.44e-01	8.48e-01	3.45e-01
REACTOME ARYL HYDROCARBON RECEPTOR SIGNALLING	6	4.63e-01	6.25e-01	0.24900	0.008040	-2.48e-01	9.73e-01	2.92e-01
REACTOME VITAMIN D CALCIFEROL METABOLISM	12	4.61e-01	6.23e-01	0.24900	0.201000	1.47e-01	2.29e-01	3.79e-01
REACTOME BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	1.85e-02	8.14e-02	0.24800	0.110000	-2.23e-01	3.63e-01	6.41e-02
REACTOME FCGR3A MEDIATED IL10 SYNTHESIS	36	9.93e-02	2.48e-01	0.24800	0.148000	2.00e-01	1.25e-01	3.81e-02
REACTOME SIGNALING BY CSF3 G CSF	28	8.97e-03	4.74e-02	0.24800	0.229000	-9.64e-02	3.62e-02	3.77e-01
REACTOME SIGNALING BY ERBB4	57	1.04e-02	5.28e-02	0.24800	0.230000	9.35e-02	2.68e-03	2.22e-01
REACTOME BETA DEFENSINS	27	1.91e-01	3.73e-01	0.24800	-0.174000	-1.77e-01	1.18e-01	1.11e-01
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	15	2.34e-01	4.26e-01	0.24800	0.054700	2.42e-01	7.14e-01	1.05e-01
REACTOME WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	4.49e-01	6.16e-01	0.24600	0.157000	1.90e-01	3.26e-01	2.36e-01
REACTOME DEFECTIVE RIPK1 MEDIATED REGULATED NECROSIS	7	4.05e-01	5.82e-01	0.24600	0.246000	-1.45e-02	2.60e-01	9.47e-01
REACTOME HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS	9	4.98e-01	6.56e-01	0.24600	0.226000	9.59e-02	2.40e-01	6.18e-01
REACTOME SHC MEDIATED CASCADE FGFR4	19	3.15e-01	4.95e-01	0.24500	0.188000	1.58e-01	1.57e-01	2.33e-01
REACTOME CATION COUPLED CHLORIDE COTRANSPORTERS	7	2.81e-01	4.74e-01	0.24500	-0.166000	1.81e-01	4.47e-01	4.08e-01
REACTOME CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	19	4.35e-02	1.43e-01	0.24500	0.224000	-9.83e-02	9.08e-02	4.58e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	1.04e-02	5.28e-02	0.24500	0.226000	-9.40e-02	3.86e-02	3.89e-01
REACTOME INACTIVATION OF CSF3 G CSF SIGNALING	23	2.72e-02	1.06e-01	0.24400	0.231000	-7.85e-02	5.46e-02	5.15e-01
REACTOME REGULATION OF IFNG SIGNALING	14	2.48e-01	4.41e-01	0.24400	0.241000	4.16e-02	1.19e-01	7.87e-01
REACTOME NEF MEDIATED CD4 DOWN REGULATION	9	5.44e-01	6.92e-01	0.24400	0.122000	2.12e-01	5.28e-01	2.72e-01
REACTOME CD209 DC SIGN SIGNALING	20	2.95e-01	4.85e-01	0.24400	0.149000	1.93e-01	2.48e-01	1.36e-01
REACTOME ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	41	8.89e-02	2.32e-01	0.24300	0.176000	1.68e-01	5.15e-02	6.21e-02
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES	8	4.22e-01	5.90e-01	0.24300	0.242000	2.22e-02	2.36e-01	9.13e-01
REACTOME FCERI MEDIATED NF KB ACTIVATION	77	1.35e-06	1.93e-05	0.24300	0.195000	-1.45e-01	3.08e-03	2.79e-02
REACTOME ABC TRANSPORTERS IN LIPID HOMEOSTASIS	17	1.88e-01	3.70e-01	0.24300	-0.239000	-4.14e-02	8.76e-02	7.68e-01
REACTOME NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	193	1.25e-05	1.45e-04	0.24300	0.165000	1.78e-01	7.97e-05	1.90e-05
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	55	3.99e-02	1.35e-01	0.24300	-0.174000	-1.69e-01	2.57e-02	3.00e-02
REACTOME DOWNREGULATION OF ERBB4 SIGNALING	9	2.97e-01	4.87e-01	0.24200	0.240000	-3.50e-02	2.13e-01	8.56e-01
REACTOME SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	4.90e-01	6.50e-01	0.24200	0.186000	1.55e-01	2.64e-01	3.53e-01
REACTOME COENZYME A BIOSYNTHESIS	8	2.53e-01	4.45e-01	0.24200	0.130000	-2.04e-01	5.24e-01	3.17e-01
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	2.07e-01	3.92e-01	0.24200	0.239000	3.99e-02	9.83e-02	7.82e-01
REACTOME CRISTAE FORMATION	9	5.78e-01	7.19e-01	0.24200	0.194000	1.44e-01	3.13e-01	4.53e-01
REACTOME EICOSANOID LIGAND BINDING RECEPTORS	14	4.43e-01	6.10e-01	0.24200	0.172000	1.69e-01	2.64e-01	2.73e-01
REACTOME SIALIC ACID METABOLISM	33	1.39e-01	3.07e-01	0.24100	0.190000	1.48e-01	5.85e-02	1.40e-01
REACTOME KEAP1 NFE2L2 PATHWAY	102	6.01e-07	9.54e-06	0.24100	0.236000	-5.05e-02	3.87e-05	3.78e-01
REACTOME FGFR2 MUTANT RECEPTOR ACTIVATION	32	1.11e-01	2.64e-01	0.24100	0.214000	1.11e-01	3.61e-02	2.79e-01
REACTOME CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	77	8.64e-03	4.65e-02	0.24100	0.199000	1.35e-01	2.52e-03	4.01e-02
REACTOME METABOLISM OF RNA	653	1.35e-48	4.42e-46	0.24000	0.144000	-1.92e-01	2.93e-10	4.03e-17
REACTOME G PROTEIN BETA GAMMA SIGNALLING	30	1.56e-01	3.28e-01	0.24000	0.134000	2.00e-01	2.04e-01	5.85e-02
REACTOME ENDOSOMAL VACUOLAR PATHWAY	11	1.48e-01	3.19e-01	0.24000	0.158000	-1.81e-01	3.64e-01	2.99e-01
REACTOME PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1	9	2.20e-01	4.09e-01	0.24000	0.204000	-1.27e-01	2.89e-01	5.11e-01
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	49	7.78e-03	4.36e-02	0.24000	0.237000	3.40e-02	4.03e-03	6.80e-01
REACTOME CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	1.93e-01	3.75e-01	0.24000	0.235000	-4.49e-02	1.58e-01	7.87e-01
REACTOME TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	29	3.07e-02	1.14e-01	0.23900	0.239000	-1.02e-02	2.57e-02	9.25e-01
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	19	2.26e-01	4.17e-01	0.23900	0.080700	2.25e-01	5.43e-01	8.91e-02
REACTOME INTERLEUKIN 12 FAMILY SIGNALING	53	1.22e-04	1.20e-03	0.23900	0.193000	-1.42e-01	1.52e-02	7.46e-02
REACTOME THE PHOTOTRANSDUCTION CASCADE	32	2.97e-02	1.12e-01	0.23900	-0.239000	-1.00e-02	1.94e-02	9.22e-01
REACTOME THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	23	2.50e-01	4.43e-01	0.23900	-0.195000	-1.38e-01	1.05e-01	2.53e-01
REACTOME SARS COV 1 INFECTION	132	1.54e-10	6.62e-09	0.23900	0.160000	-1.77e-01	1.48e-03	4.46e-04
REACTOME MRNA SPLICING MINOR PATHWAY	48	3.49e-04	3.16e-03	0.23800	0.127000	-2.01e-01	1.27e-01	1.57e-02
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	8.74e-03	4.65e-02	0.23800	0.190000	-1.43e-01	8.12e-02	1.89e-01
REACTOME ACYL CHAIN REMODELING OF DAG AND TAG	5	6.19e-01	7.51e-01	0.23800	0.038400	2.35e-01	8.82e-01	3.63e-01
REACTOME SUMOYLATION OF DNA METHYLATION PROTEINS	16	3.73e-01	5.54e-01	0.23800	0.129000	2.00e-01	3.71e-01	1.66e-01
REACTOME PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	21	2.85e-01	4.77e-01	0.23700	0.195000	1.35e-01	1.22e-01	2.83e-01
REACTOME MRNA EDITING C TO U CONVERSION	8	2.94e-01	4.85e-01	0.23700	0.088400	-2.20e-01	6.65e-01	2.80e-01
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	105	1.13e-06	1.64e-05	0.23700	0.235000	-3.68e-02	3.24e-05	5.15e-01
REACTOME SIGNALING BY WNT	262	8.14e-08	1.60e-06	0.23700	0.204000	1.22e-01	1.35e-08	6.61e-04
REACTOME E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	41	1.15e-03	8.99e-03	0.23700	0.196000	-1.33e-01	3.02e-02	1.40e-01
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX3	92	2.26e-06	3.08e-05	0.23600	0.228000	-6.35e-02	1.58e-04	2.93e-01
REACTOME PHASE 4 RESTING MEMBRANE POTENTIAL	19	3.48e-01	5.30e-01	0.23600	0.165000	1.69e-01	2.13e-01	2.03e-01
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	32	1.33e-01	3.00e-01	0.23600	0.204000	1.17e-01	4.53e-02	2.51e-01
REACTOME ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	22	2.01e-01	3.86e-01	0.23500	0.086500	2.19e-01	4.83e-01	7.54e-02
REACTOME SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	90	3.65e-07	6.04e-06	0.23500	0.188000	-1.41e-01	2.03e-03	2.05e-02
REACTOME SIGNALING BY EGFR IN CANCER	25	4.00e-02	1.35e-01	0.23500	0.232000	-3.75e-02	4.44e-02	7.46e-01
REACTOME PHASE 0 RAPID DEPOLARISATION	31	1.81e-01	3.62e-01	0.23500	-0.167000	-1.65e-01	1.07e-01	1.11e-01
REACTOME FORMATION OF APOPTOSOME	10	2.37e-01	4.28e-01	0.23500	0.223000	-7.32e-02	2.22e-01	6.88e-01
REACTOME UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	2.26e-01	4.17e-01	0.23400	-0.228000	5.41e-02	1.91e-01	7.56e-01
REACTOME TRANSCRIPTIONAL REGULATION BY NPAS4	32	1.74e-01	3.52e-01	0.23400	0.173000	1.57e-01	8.94e-02	1.25e-01
REACTOME TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	26	2.02e-01	3.87e-01	0.23300	0.202000	1.16e-01	7.45e-02	3.04e-01
REACTOME REGULATED PROTEOLYSIS OF P75NTR	11	4.69e-01	6.31e-01	0.23300	0.214000	9.36e-02	2.20e-01	5.91e-01
REACTOME SODIUM COUPLED PHOSPHATE COTRANSPORTERS	5	7.62e-01	8.50e-01	0.23300	-0.159000	-1.70e-01	5.37e-01	5.10e-01
REACTOME ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	42	1.01e-01	2.50e-01	0.23300	0.152000	1.77e-01	8.86e-02	4.76e-02
REACTOME ACTIVATION OF RAS IN B CELLS	5	6.23e-01	7.53e-01	0.23300	0.231000	3.08e-02	3.71e-01	9.05e-01
REACTOME BETA OXIDATION OF HEXANOYL COA TO BUTANOYL COA	5	6.47e-01	7.72e-01	0.23300	0.228000	4.70e-02	3.77e-01	8.56e-01
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE GIP	12	2.06e-01	3.91e-01	0.23300	0.227000	-5.01e-02	1.73e-01	7.64e-01
REACTOME PLASMA LIPOPROTEIN CLEARANCE	37	7.13e-02	2.01e-01	0.23300	0.217000	8.49e-02	2.26e-02	3.72e-01
REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	15	3.70e-01	5.51e-01	0.23200	-0.210000	-9.84e-02	1.59e-01	5.09e-01
REACTOME NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	44	9.93e-04	7.92e-03	0.23200	0.196000	-1.24e-01	2.44e-02	1.55e-01
REACTOME DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	15	1.03e-01	2.53e-01	0.23200	0.207000	-1.04e-01	1.64e-01	4.86e-01
REACTOME BETA OXIDATION OF DECANOYL COA TO OCTANOYL COA COA	6	5.90e-01	7.29e-01	0.23200	0.228000	4.35e-02	3.34e-01	8.54e-01
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX2	116	1.07e-06	1.57e-05	0.23200	0.231000	-2.34e-02	1.76e-05	6.63e-01
REACTOME SIGNALING BY FGFR2 IN DISEASE	42	7.87e-02	2.14e-01	0.23200	0.200000	1.17e-01	2.48e-02	1.90e-01
REACTOME PHASE 3 RAPID REPOLARISATION	8	3.93e-01	5.72e-01	0.23100	-0.019200	2.31e-01	9.25e-01	2.59e-01
REACTOME PHOSPHORYLATION OF THE APC C	20	6.28e-02	1.84e-01	0.23100	0.220000	-6.97e-02	8.80e-02	5.89e-01
REACTOME GENERATION OF SECOND MESSENGER MOLECULES	29	1.51e-01	3.22e-01	0.23100	0.209000	9.94e-02	5.19e-02	3.54e-01
REACTOME RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION	6	6.95e-01	8.05e-01	0.23100	0.114000	2.01e-01	6.30e-01	3.95e-01
REACTOME TRANSPORT OF NUCLEOTIDE SUGARS	8	5.78e-01	7.19e-01	0.23000	0.213000	8.89e-02	2.98e-01	6.63e-01
REACTOME VLDL ASSEMBLY	5	7.52e-01	8.41e-01	0.23000	-0.127000	-1.92e-01	6.23e-01	4.58e-01
REACTOME RORA ACTIVATES GENE EXPRESSION	17	2.80e-01	4.73e-01	0.23000	0.070100	2.19e-01	6.17e-01	1.19e-01
REACTOME DISEASES OF MITOTIC CELL CYCLE	37	6.98e-03	4.01e-02	0.22900	0.220000	-6.37e-02	2.03e-02	5.02e-01
REACTOME STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING	9	3.38e-01	5.19e-01	0.22900	0.227000	-3.18e-02	2.38e-01	8.69e-01
REACTOME SYNTHESIS OF PA	35	4.44e-02	1.44e-01	0.22900	-0.226000	-3.54e-02	2.06e-02	7.17e-01
REACTOME SIGNALING BY NOTCH3	48	4.15e-02	1.38e-01	0.22800	0.210000	9.06e-02	1.19e-02	2.77e-01
REACTOME TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	16	1.39e-01	3.07e-01	0.22800	0.225000	-4.01e-02	1.19e-01	7.81e-01
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	1.36e-01	3.02e-01	0.22800	0.063700	-2.19e-01	6.69e-01	1.41e-01
REACTOME DEX H BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION	7	3.83e-01	5.63e-01	0.22800	0.074600	-2.16e-01	7.32e-01	3.23e-01
REACTOME CIRCADIAN CLOCK	66	2.42e-02	9.81e-02	0.22800	0.192000	1.24e-01	7.12e-03	8.18e-02
REACTOME CITRIC ACID CYCLE TCA CYCLE	21	3.99e-02	1.35e-01	0.22800	0.129000	-1.88e-01	3.05e-01	1.37e-01
REACTOME FORMATION OF XYLULOSE 5 PHOSPHATE	5	5.33e-01	6.84e-01	0.22800	0.223000	-4.80e-02	3.89e-01	8.53e-01
REACTOME NETRIN MEDIATED REPULSION SIGNALS	8	6.51e-01	7.76e-01	0.22800	0.182000	1.37e-01	3.73e-01	5.03e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	12	3.63e-01	5.43e-01	0.22800	0.043100	2.23e-01	7.96e-01	1.80e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS	12	5.35e-01	6.85e-01	0.22800	0.172000	1.49e-01	3.01e-01	3.73e-01
REACTOME SUPPRESSION OF PHAGOSOMAL MATURATION	13	1.39e-01	3.07e-01	0.22700	0.125000	-1.90e-01	4.36e-01	2.35e-01
REACTOME TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	20	3.34e-01	5.15e-01	0.22700	0.187000	1.29e-01	1.48e-01	3.18e-01
REACTOME GABA B RECEPTOR ACTIVATION	43	9.98e-02	2.48e-01	0.22700	0.183000	1.35e-01	3.82e-02	1.26e-01
REACTOME METABOLISM OF COFACTORS	19	6.05e-02	1.80e-01	0.22600	0.196000	-1.14e-01	1.40e-01	3.92e-01
REACTOME HEME BIOSYNTHESIS	13	2.56e-01	4.49e-01	0.22600	0.004520	-2.26e-01	9.77e-01	1.58e-01
REACTOME WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	4.57e-01	6.21e-01	0.22600	0.177000	1.41e-01	2.36e-01	3.45e-01
REACTOME PREDNISONE ADME	10	5.73e-01	7.16e-01	0.22600	-0.191000	-1.21e-01	2.96e-01	5.08e-01
REACTOME SIGNALING BY KIT IN DISEASE	20	3.16e-01	4.95e-01	0.22500	0.196000	1.12e-01	1.30e-01	3.87e-01
REACTOME VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	42	1.20e-01	2.78e-01	0.22500	0.163000	1.55e-01	6.79e-02	8.12e-02
REACTOME PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	21	1.58e-01	3.30e-01	0.22500	0.223000	3.06e-02	7.69e-02	8.08e-01
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	28	4.74e-02	1.50e-01	0.22500	0.015900	-2.24e-01	8.84e-01	3.98e-02
REACTOME DOWNREGULATION OF ERBB2 SIGNALING	28	8.12e-02	2.19e-01	0.22500	0.223000	2.60e-02	4.09e-02	8.12e-01
REACTOME PKA ACTIVATION IN GLUCAGON SIGNALLING	17	3.07e-01	4.92e-01	0.22400	0.073200	2.12e-01	6.01e-01	1.31e-01
REACTOME SIGNALING BY FGFR4	40	4.14e-02	1.38e-01	0.22400	0.219000	4.72e-02	1.67e-02	6.05e-01
REACTOME ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS	5	5.23e-01	6.77e-01	0.22400	-0.213000	6.73e-02	4.09e-01	7.94e-01
REACTOME SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	16	2.78e-01	4.71e-01	0.22400	0.219000	4.59e-02	1.30e-01	7.50e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	1.48e-02	6.82e-02	0.22300	0.148000	-1.67e-01	1.75e-01	1.26e-01
REACTOME NADE MODULATES DEATH SIGNALLING	5	7.04e-01	8.10e-01	0.22300	0.212000	6.95e-02	4.11e-01	7.88e-01
REACTOME INTERLEUKIN 2 SIGNALING	11	2.30e-01	4.21e-01	0.22300	0.208000	-7.96e-02	2.31e-01	6.48e-01
REACTOME ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	10	2.61e-01	4.55e-01	0.22300	0.207000	-8.18e-02	2.56e-01	6.54e-01
REACTOME REGULATION OF TP53 EXPRESSION AND DEGRADATION	37	7.57e-02	2.09e-01	0.22300	0.211000	6.95e-02	2.60e-02	4.64e-01
REACTOME DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	19	9.19e-02	2.35e-01	0.22300	0.214000	-6.00e-02	1.06e-01	6.51e-01
REACTOME MITOTIC G1 PHASE AND G1 S TRANSITION	144	1.34e-09	4.99e-08	0.22300	0.194000	-1.09e-01	5.83e-05	2.35e-02
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	51	7.85e-02	2.14e-01	0.22200	0.170000	1.42e-01	3.51e-02	7.87e-02
REACTOME NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	22	7.36e-02	2.05e-01	0.22200	0.217000	-4.47e-02	7.75e-02	7.17e-01
REACTOME ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	59	4.05e-02	1.36e-01	0.22200	0.189000	1.16e-01	1.20e-02	1.23e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	3.48e-02	1.23e-01	0.22200	0.180000	-1.29e-01	1.34e-01	2.84e-01
REACTOME HOST INTERACTIONS OF HIV FACTORS	122	2.44e-08	6.12e-07	0.22200	0.186000	-1.21e-01	3.86e-04	2.13e-02
REACTOME ACTIVATED NTRK3 SIGNALS THROUGH RAS	8	5.56e-01	6.99e-01	0.22100	0.214000	5.80e-02	2.95e-01	7.76e-01
REACTOME SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	54	2.86e-02	1.10e-01	0.22100	0.207000	7.74e-02	8.39e-03	3.25e-01
REACTOME ABACAVIR TRANSMEMBRANE TRANSPORT	5	5.06e-01	6.63e-01	0.22100	-0.092400	2.01e-01	7.21e-01	4.36e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	26	2.52e-01	4.44e-01	0.22100	0.186000	1.19e-01	1.01e-01	2.93e-01
REACTOME ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	74	2.42e-02	9.81e-02	0.22100	0.133000	1.76e-01	4.77e-02	8.82e-03
REACTOME PHASE I FUNCTIONALIZATION OF COMPOUNDS	98	8.54e-03	4.62e-02	0.22000	-0.146000	-1.65e-01	1.27e-02	4.66e-03
REACTOME SIGNALING BY NOTCH1	69	1.43e-02	6.66e-02	0.22000	0.202000	8.71e-02	3.69e-03	2.11e-01
REACTOME THE ACTIVATION OF ARYLSULFATASES	8	5.42e-01	6.92e-01	0.22000	0.215000	4.76e-02	2.93e-01	8.16e-01
REACTOME REGULATION OF PTEN STABILITY AND ACTIVITY	66	7.70e-05	7.82e-04	0.22000	0.178000	-1.29e-01	1.24e-02	6.93e-02
REACTOME PROTEIN LOCALIZATION	147	7.36e-10	2.87e-08	0.22000	0.129000	-1.78e-01	6.75e-03	1.97e-04
REACTOME PEROXISOMAL PROTEIN IMPORT	62	6.87e-04	5.67e-03	0.22000	0.047400	-2.15e-01	5.19e-01	3.46e-03
REACTOME NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	5.88e-01	7.28e-01	0.22000	0.161000	1.49e-01	3.55e-01	3.91e-01
REACTOME GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	25	9.00e-02	2.33e-01	0.21900	0.219000	3.95e-04	5.78e-02	9.97e-01
REACTOME SIGNALING BY EGFR	49	5.85e-02	1.76e-01	0.21900	0.197000	9.55e-02	1.72e-02	2.47e-01
REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	25	2.44e-01	4.37e-01	0.21900	0.194000	1.01e-01	9.32e-02	3.83e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	88	2.07e-05	2.32e-04	0.21900	0.209000	-6.35e-02	6.94e-04	3.03e-01
REACTOME REGULATION OF PTEN GENE TRANSCRIPTION	59	3.24e-02	1.18e-01	0.21800	0.197000	9.38e-02	8.84e-03	2.13e-01
REACTOME PROTEIN UBIQUITINATION	59	4.52e-04	3.93e-03	0.21700	0.198000	-8.90e-02	8.38e-03	2.37e-01
REACTOME PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	77	2.59e-02	1.03e-01	0.21700	0.140000	1.66e-01	3.33e-02	1.20e-02
REACTOME NUCLEAR SIGNALING BY ERBB4	32	1.94e-01	3.75e-01	0.21700	0.183000	1.16e-01	7.34e-02	2.54e-01
REACTOME PI5P REGULATES TP53 ACETYLATION	8	4.82e-01	6.42e-01	0.21700	0.217000	7.22e-03	2.89e-01	9.72e-01
REACTOME ORGANIC CATION TRANSPORT	10	3.55e-01	5.36e-01	0.21700	-0.021300	2.16e-01	9.07e-01	2.38e-01
REACTOME RUNX2 REGULATES CHONDROCYTE MATURATION	5	7.68e-01	8.55e-01	0.21700	0.109000	1.87e-01	6.73e-01	4.69e-01
REACTOME CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	25	4.41e-02	1.44e-01	0.21600	0.203000	-7.48e-02	7.88e-02	5.17e-01
REACTOME REDUCTION OF CYTOSOLIC CA LEVELS	11	2.93e-01	4.84e-01	0.21600	-0.040500	2.12e-01	8.16e-01	2.22e-01
REACTOME SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	14	4.81e-01	6.42e-01	0.21600	0.186000	1.10e-01	2.29e-01	4.75e-01
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	22	3.06e-01	4.92e-01	0.21600	0.103000	1.89e-01	4.01e-01	1.24e-01
REACTOME ERBB2 ACTIVATES PTK6 SIGNALING	13	4.50e-01	6.16e-01	0.21500	0.201000	7.85e-02	2.10e-01	6.24e-01
REACTOME CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	5.20e-01	6.75e-01	0.21500	0.084300	1.98e-01	6.28e-01	2.55e-01
REACTOME CHAPERONE MEDIATED AUTOPHAGY	20	1.11e-01	2.64e-01	0.21500	0.039500	-2.12e-01	7.59e-01	1.01e-01
REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	22	3.02e-01	4.90e-01	0.21500	0.190000	1.00e-01	1.22e-01	4.17e-01
REACTOME EFFECTS OF PIP2 HYDROLYSIS	26	2.46e-01	4.40e-01	0.21500	0.102000	1.90e-01	3.70e-01	9.44e-02
REACTOME SIGNALING BY FGFR2	72	1.05e-03	8.29e-03	0.21500	0.215000	-6.38e-03	1.63e-03	9.25e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	28	2.32e-01	4.24e-01	0.21500	0.107000	1.86e-01	3.27e-01	8.83e-02
REACTOME LYSOSOME VESICLE BIOGENESIS	33	6.40e-02	1.86e-01	0.21400	0.213000	2.08e-02	3.39e-02	8.36e-01
REACTOME INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	14	1.84e-01	3.67e-01	0.21400	0.203000	-6.97e-02	1.89e-01	6.52e-01
REACTOME DEFECTIVE EXT2 CAUSES EXOSTOSES 2	12	5.28e-01	6.81e-01	0.21400	-0.188000	-1.02e-01	2.59e-01	5.41e-01
REACTOME STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	13	5.19e-01	6.74e-01	0.21400	-0.113000	-1.82e-01	4.79e-01	2.57e-01
REACTOME SIGNALING BY FLT3 ITD AND TKD MUTANTS	16	1.58e-01	3.31e-01	0.21400	0.207000	-5.55e-02	1.53e-01	7.01e-01
REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	14	4.45e-01	6.11e-01	0.21400	0.085900	1.96e-01	5.78e-01	2.05e-01
REACTOME LGI ADAM INTERACTIONS	14	3.52e-01	5.34e-01	0.21400	0.210000	4.05e-02	1.74e-01	7.93e-01
REACTOME PHASE II CONJUGATION OF COMPOUNDS	101	1.00e-02	5.13e-02	0.21400	-0.143000	-1.59e-01	1.33e-02	5.75e-03
REACTOME ANCHORING FIBRIL FORMATION	13	5.45e-01	6.92e-01	0.21300	0.132000	1.68e-01	4.10e-01	2.96e-01
REACTOME METABOLISM OF FAT SOLUBLE VITAMINS	46	1.15e-01	2.70e-01	0.21300	-0.171000	-1.27e-01	4.49e-02	1.36e-01
REACTOME MET RECEPTOR RECYCLING	10	2.72e-01	4.65e-01	0.21300	0.186000	-1.03e-01	3.08e-01	5.71e-01
REACTOME FGFR3B LIGAND BINDING AND ACTIVATION	7	7.26e-01	8.25e-01	0.21300	0.137000	1.62e-01	5.29e-01	4.57e-01
REACTOME BETA CATENIN PHOSPHORYLATION CASCADE	16	4.35e-01	6.03e-01	0.21200	0.186000	1.02e-01	1.97e-01	4.80e-01
REACTOME RESOLUTION OF ABASIC SITES AP SITES	37	7.87e-02	2.14e-01	0.21200	0.206000	5.18e-02	3.04e-02	5.85e-01
REACTOME ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	28	2.41e-01	4.32e-01	0.21000	0.184000	1.02e-01	9.20e-02	3.51e-01
REACTOME INTERLEUKIN 21 SIGNALING	9	3.10e-01	4.94e-01	0.21000	0.117000	-1.75e-01	5.44e-01	3.64e-01
REACTOME SUMO IS TRANSFERRED FROM E1 TO E2 UBE2I UBC9	7	4.59e-01	6.22e-01	0.21000	0.202000	-5.53e-02	3.54e-01	8.00e-01
REACTOME CA2 PATHWAY	62	4.84e-02	1.52e-01	0.21000	0.108000	1.79e-01	1.41e-01	1.45e-02
REACTOME RNA POLYMERASE II TRANSCRIPTION TERMINATION	61	3.11e-04	2.86e-03	0.21000	0.153000	-1.43e-01	3.88e-02	5.30e-02
REACTOME SYNTHESIS OF PIPS AT THE ER MEMBRANE	5	7.93e-01	8.71e-01	0.20900	0.121000	1.71e-01	6.39e-01	5.08e-01
REACTOME HIV ELONGATION ARREST AND RECOVERY	29	2.29e-02	9.46e-02	0.20900	0.123000	-1.69e-01	2.50e-01	1.15e-01
REACTOME DNA REPLICATION INITIATION	7	6.28e-01	7.57e-01	0.20900	0.203000	5.22e-02	3.53e-01	8.11e-01
REACTOME SIGNALING BY PTK6	54	9.35e-03	4.89e-02	0.20900	0.209000	2.30e-03	7.93e-03	9.77e-01
REACTOME SUMOYLATION OF TRANSCRIPTION COFACTORS	42	1.61e-01	3.34e-01	0.20900	0.143000	1.53e-01	1.10e-01	8.70e-02
REACTOME BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	19	3.03e-01	4.90e-01	0.20900	0.200000	6.09e-02	1.32e-01	6.46e-01
REACTOME NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	5.32e-01	6.83e-01	0.20800	0.194000	7.63e-02	2.65e-01	6.61e-01
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	29	2.40e-01	4.31e-01	0.20800	0.181000	1.03e-01	9.20e-02	3.35e-01
REACTOME B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	28	3.08e-02	1.14e-01	0.20800	0.182000	-1.01e-01	9.60e-02	3.53e-01
REACTOME INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	18	1.24e-01	2.84e-01	0.20800	0.073300	-1.95e-01	5.90e-01	1.53e-01
REACTOME CLATHRIN MEDIATED ENDOCYTOSIS	137	3.59e-04	3.22e-03	0.20800	0.195000	7.28e-02	8.19e-05	1.41e-01
REACTOME TRANSPORT OF ORGANIC ANIONS	10	6.32e-01	7.60e-01	0.20800	-0.171000	-1.18e-01	3.49e-01	5.17e-01
REACTOME CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE	8	4.98e-01	6.56e-01	0.20800	-0.000522	2.08e-01	9.98e-01	3.09e-01
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	2.93e-01	4.84e-01	0.20800	0.160000	1.32e-01	1.42e-01	2.25e-01
REACTOME DNA DAMAGE REVERSAL	8	3.96e-01	5.73e-01	0.20800	-0.194000	7.42e-02	3.42e-01	7.16e-01
REACTOME NEGATIVE REGULATION OF MAPK PATHWAY	41	1.39e-02	6.54e-02	0.20700	0.202000	-4.42e-02	2.49e-02	6.24e-01
REACTOME LDL CLEARANCE	19	3.98e-01	5.75e-01	0.20700	0.179000	1.04e-01	1.77e-01	4.33e-01
REACTOME EPH EPHRIN SIGNALING	90	5.66e-03	3.36e-02	0.20700	0.194000	7.25e-02	1.47e-03	2.35e-01
REACTOME RHO GTPASES ACTIVATE PAKS	19	4.35e-01	6.03e-01	0.20700	0.163000	1.28e-01	2.20e-01	3.34e-01
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	60	3.91e-02	1.33e-01	0.20700	0.189000	8.30e-02	1.11e-02	2.66e-01
REACTOME CALCITONIN LIKE LIGAND RECEPTORS	10	4.22e-01	5.90e-01	0.20700	0.207000	-8.67e-04	2.58e-01	9.96e-01
REACTOME GLUTAMATE AND GLUTAMINE METABOLISM	11	3.83e-01	5.63e-01	0.20700	0.207000	-3.51e-03	2.36e-01	9.84e-01
REACTOME CRMPS IN SEMA3A SIGNALING	15	4.99e-01	6.56e-01	0.20700	0.174000	1.12e-01	2.44e-01	4.54e-01
REACTOME CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	98	3.28e-03	2.23e-02	0.20600	0.195000	6.85e-02	8.64e-04	2.41e-01
REACTOME TRNA PROCESSING IN THE NUCLEUS	55	1.00e-03	7.98e-03	0.20600	0.116000	-1.70e-01	1.36e-01	2.87e-02
REACTOME EGFR INTERACTS WITH PHOSPHOLIPASE C GAMMA	9	6.83e-01	7.97e-01	0.20600	0.144000	1.48e-01	4.54e-01	4.43e-01
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	36	1.00e-02	5.13e-02	0.20600	0.150000	-1.41e-01	1.18e-01	1.44e-01
REACTOME DNA REPLICATION PRE INITIATION	96	5.74e-06	7.17e-05	0.20600	0.166000	-1.21e-01	4.87e-03	3.96e-02
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	20	8.57e-02	2.26e-01	0.20500	0.175000	-1.07e-01	1.74e-01	4.08e-01
REACTOME ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	28	3.06e-01	4.92e-01	0.20500	0.153000	1.37e-01	1.61e-01	2.10e-01
REACTOME BASE EXCISION REPAIR AP SITE FORMATION	17	1.51e-01	3.22e-01	0.20500	0.194000	-6.81e-02	1.67e-01	6.27e-01
REACTOME GLUTATHIONE SYNTHESIS AND RECYCLING	12	5.47e-01	6.92e-01	0.20500	-0.092100	-1.83e-01	5.81e-01	2.72e-01
REACTOME UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN	6	5.05e-01	6.61e-01	0.20500	0.077400	-1.90e-01	7.43e-01	4.21e-01
REACTOME ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	15	5.31e-01	6.83e-01	0.20500	0.135000	1.54e-01	3.67e-01	3.01e-01
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	24	2.64e-01	4.58e-01	0.20500	0.191000	7.43e-02	1.06e-01	5.29e-01
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	31	1.06e-01	2.58e-01	0.20400	0.202000	2.75e-02	5.11e-02	7.91e-01
REACTOME HSF1 ACTIVATION	29	2.77e-02	1.07e-01	0.20400	0.167000	-1.18e-01	1.20e-01	2.71e-01
REACTOME RAF INDEPENDENT MAPK1 3 ACTIVATION	22	3.19e-01	4.97e-01	0.20400	0.186000	8.46e-02	1.31e-01	4.92e-01
REACTOME INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	25	5.53e-02	1.69e-01	0.20400	0.185000	-8.54e-02	1.08e-01	4.60e-01
REACTOME REGULATION OF TP53 ACTIVITY	153	1.58e-04	1.53e-03	0.20400	0.193000	6.71e-02	3.82e-05	1.52e-01
REACTOME TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	19	1.32e-01	2.98e-01	0.20400	0.195000	-5.87e-02	1.41e-01	6.58e-01
REACTOME APOPTOSIS	164	2.53e-08	6.12e-07	0.20400	0.195000	-6.04e-02	1.69e-05	1.82e-01
REACTOME TCR SIGNALING	111	4.03e-06	5.15e-05	0.20400	0.189000	-7.58e-02	5.81e-04	1.68e-01
REACTOME SIGNALING BY NOTCH2	32	6.71e-02	1.92e-01	0.20400	0.204000	-2.98e-03	4.63e-02	9.77e-01
REACTOME DUAL INCISION IN GG NER	39	2.35e-02	9.62e-02	0.20300	0.201000	-3.21e-02	2.99e-02	7.29e-01
REACTOME NPAS4 REGULATES EXPRESSION OF TARGET GENES	20	3.14e-01	4.95e-01	0.20300	0.193000	6.43e-02	1.35e-01	6.18e-01
REACTOME CYP2E1 REACTIONS	10	6.20e-01	7.52e-01	0.20300	-0.178000	-9.74e-02	3.29e-01	5.94e-01
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	35	1.68e-01	3.46e-01	0.20300	0.184000	8.56e-02	5.93e-02	3.81e-01
REACTOME SUMOYLATION	163	1.25e-03	9.73e-03	0.20300	0.150000	1.37e-01	9.61e-04	2.52e-03
REACTOME SYNTHESIS OF DNA	118	1.48e-06	2.09e-05	0.20300	0.185000	-8.38e-02	5.19e-04	1.16e-01
REACTOME INTEGRATION OF ENERGY METABOLISM	105	1.30e-02	6.19e-02	0.20300	0.133000	1.53e-01	1.87e-02	6.56e-03
REACTOME CLEC7A DECTIN 1 SIGNALING	96	1.19e-05	1.39e-04	0.20300	0.176000	-1.01e-01	2.88e-03	8.81e-02
REACTOME SNRNP ASSEMBLY	51	1.95e-03	1.41e-02	0.20200	0.125000	-1.59e-01	1.23e-01	4.93e-02
REACTOME ACTIVATED NTRK3 SIGNALS THROUGH PI3K	6	7.83e-01	8.66e-01	0.20200	0.142000	1.43e-01	5.46e-01	5.43e-01
REACTOME RET SIGNALING	40	1.36e-01	3.02e-01	0.20200	0.086800	1.83e-01	3.42e-01	4.57e-02
REACTOME REGULATION OF IFNA IFNB SIGNALING	23	2.36e-01	4.28e-01	0.20200	-0.196000	-4.87e-02	1.03e-01	6.86e-01
REACTOME DNA REPLICATION	124	6.56e-07	1.03e-05	0.20100	0.178000	-9.37e-02	6.06e-04	7.16e-02
REACTOME G1 S SPECIFIC TRANSCRIPTION	28	4.37e-02	1.43e-01	0.20100	0.184000	-8.17e-02	9.20e-02	4.54e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS	5	8.17e-01	8.87e-01	0.20100	-0.147000	-1.37e-01	5.70e-01	5.95e-01
REACTOME GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION	7	6.13e-01	7.46e-01	0.20100	0.199000	2.77e-02	3.62e-01	8.99e-01
REACTOME ATTENUATION PHASE	27	4.17e-02	1.38e-01	0.20100	0.169000	-1.07e-01	1.28e-01	3.34e-01
REACTOME COBALAMIN CBL METABOLISM	6	5.19e-01	6.74e-01	0.20000	0.076900	-1.85e-01	7.44e-01	4.33e-01
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	45	1.55e-01	3.28e-01	0.20000	0.160000	1.20e-01	6.32e-02	1.63e-01
REACTOME DAG AND IP3 SIGNALING	39	1.33e-01	3.00e-01	0.20000	0.076700	1.85e-01	4.07e-01	4.57e-02
REACTOME INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	28	3.94e-02	1.34e-01	0.20000	0.173000	-1.01e-01	1.14e-01	3.57e-01
REACTOME ACTIVATION OF NIMA KINASES NEK9 NEK6 NEK7	7	4.73e-01	6.35e-01	0.20000	0.187000	-6.99e-02	3.91e-01	7.49e-01
REACTOME DNA DAMAGE BYPASS	45	3.01e-02	1.12e-01	0.20000	0.200000	5.59e-03	2.04e-02	9.48e-01
REACTOME MET RECEPTOR ACTIVATION	6	6.95e-01	8.05e-01	0.20000	-0.049500	-1.93e-01	8.34e-01	4.12e-01
REACTOME COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	38	4.41e-02	1.44e-01	0.20000	0.200000	-5.14e-03	3.32e-02	9.56e-01
REACTOME PROCESSING AND ACTIVATION OF SUMO	10	3.01e-01	4.90e-01	0.19900	0.145000	-1.37e-01	4.26e-01	4.55e-01
REACTOME RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	16	4.15e-01	5.88e-01	0.19900	0.064800	1.88e-01	6.54e-01	1.92e-01
REACTOME BUDDING AND MATURATION OF HIV VIRION	28	8.06e-02	2.18e-01	0.19900	0.197000	-2.66e-02	7.13e-02	8.07e-01
REACTOME CREB3 FACTORS ACTIVATE GENES	8	5.75e-01	7.18e-01	0.19900	-0.025500	-1.97e-01	9.00e-01	3.35e-01
REACTOME ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION	10	5.47e-01	6.92e-01	0.19800	0.192000	4.79e-02	2.92e-01	7.93e-01
REACTOME CELLULAR RESPONSE TO CHEMICAL STRESS	186	1.55e-09	5.65e-08	0.19800	0.179000	-8.49e-02	2.50e-05	4.58e-02
REACTOME COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	32	2.62e-02	1.03e-01	0.19800	0.169000	-1.03e-01	9.80e-02	3.14e-01
REACTOME DISEASES ASSOCIATED WITH SURFACTANT METABOLISM	9	5.38e-01	6.87e-01	0.19800	-0.196000	-2.42e-02	3.08e-01	9.00e-01
REACTOME CELLULAR HEXOSE TRANSPORT	20	4.60e-01	6.23e-01	0.19700	-0.138000	-1.41e-01	2.86e-01	2.74e-01
REACTOME MTORC1 MEDIATED SIGNALLING	23	1.09e-01	2.61e-01	0.19700	0.192000	-4.72e-02	1.12e-01	6.95e-01
REACTOME MASTL FACILITATES MITOTIC PROGRESSION	10	3.20e-01	4.97e-01	0.19700	0.107000	-1.65e-01	5.57e-01	3.65e-01
REACTOME VITAMIN B1 THIAMIN METABOLISM	5	6.82e-01	7.97e-01	0.19700	0.197000	3.14e-03	4.46e-01	9.90e-01
REACTOME ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN	13	4.41e-01	6.08e-01	0.19600	-0.037100	-1.93e-01	8.17e-01	2.29e-01
REACTOME CA2 ACTIVATED K CHANNELS	9	6.89e-01	8.02e-01	0.19600	-0.109000	-1.63e-01	5.72e-01	3.96e-01
REACTOME MET ACTIVATES PTK2 SIGNALING	30	1.54e-01	3.26e-01	0.19600	-0.192000	-3.82e-02	6.81e-02	7.17e-01
REACTOME DISEASES OF PROGRAMMED CELL DEATH	42	9.88e-03	5.11e-02	0.19600	0.172000	-9.46e-02	5.42e-02	2.89e-01
REACTOME SIGNALING BY HEDGEHOG	146	1.79e-05	2.05e-04	0.19600	0.196000	4.51e-03	4.41e-05	9.25e-01
REACTOME REGULATED NECROSIS	55	1.73e-03	1.29e-02	0.19600	0.140000	-1.37e-01	7.24e-02	7.92e-02
REACTOME CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	60	1.42e-03	1.07e-02	0.19600	0.093100	-1.72e-01	2.12e-01	2.10e-02
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	24	3.87e-01	5.66e-01	0.19600	0.156000	1.19e-01	1.87e-01	3.15e-01
REACTOME PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS	7	4.61e-01	6.23e-01	0.19600	0.169000	-9.80e-02	4.38e-01	6.54e-01
REACTOME P75NTR REGULATES AXONOGENESIS	9	5.19e-01	6.74e-01	0.19600	-0.195000	-9.80e-03	3.10e-01	9.59e-01
REACTOME PKMTS METHYLATE HISTONE LYSINES	37	4.42e-02	1.44e-01	0.19500	-0.019600	1.94e-01	8.36e-01	4.08e-02
REACTOME SUMO IS PROTEOLYTICALLY PROCESSED	6	5.12e-01	6.69e-01	0.19500	0.165000	-1.05e-01	4.85e-01	6.57e-01
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	50	3.23e-03	2.21e-02	0.19500	0.132000	-1.44e-01	1.07e-01	7.83e-02
REACTOME THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	143	9.10e-08	1.71e-06	0.19500	0.123000	-1.51e-01	1.09e-02	1.83e-03
REACTOME COLLAGEN CHAIN TRIMERIZATION	42	4.42e-02	1.44e-01	0.19400	-0.194000	-3.86e-03	2.94e-02	9.65e-01
REACTOME G2 M CHECKPOINTS	126	8.60e-07	1.28e-05	0.19400	0.161000	-1.09e-01	1.84e-03	3.42e-02
REACTOME HEDGEHOG OFF STATE	110	2.81e-05	3.07e-04	0.19400	0.186000	-5.35e-02	7.38e-04	3.32e-01
REACTOME ELASTIC FIBRE FORMATION	44	1.10e-01	2.63e-01	0.19400	0.068800	1.81e-01	4.30e-01	3.77e-02
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	98	3.18e-05	3.42e-04	0.19400	0.087900	-1.72e-01	1.33e-01	3.16e-03
REACTOME PRC2 METHYLATES HISTONES AND DNA	12	5.98e-01	7.35e-01	0.19300	0.094800	1.69e-01	5.70e-01	3.12e-01
REACTOME RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	54	5.22e-03	3.22e-02	0.19300	0.059800	-1.84e-01	4.47e-01	1.94e-02
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	74	1.53e-02	6.94e-02	0.19300	0.187000	4.81e-02	5.42e-03	4.74e-01
REACTOME INTERLEUKIN 1 SIGNALING	109	1.18e-05	1.39e-04	0.19300	0.173000	-8.48e-02	1.77e-03	1.26e-01
REACTOME TRANSCRIPTION OF THE HIV GENOME	62	1.04e-03	8.23e-03	0.19300	0.153000	-1.17e-01	3.73e-02	1.10e-01
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	340	2.31e-16	1.89e-14	0.19200	0.097700	-1.66e-01	1.94e-03	1.47e-07
REACTOME NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	33	2.55e-02	1.02e-01	0.19200	0.146000	-1.25e-01	1.47e-01	2.14e-01
REACTOME FC EPSILON RECEPTOR FCERI SIGNALING	126	6.87e-06	8.39e-05	0.19200	0.184000	-5.52e-02	3.59e-04	2.84e-01
REACTOME REGULATION OF SIGNALING BY NODAL	10	6.82e-01	7.97e-01	0.19200	0.115000	1.54e-01	5.29e-01	4.00e-01
REACTOME BIOLOGICAL OXIDATIONS	206	5.07e-04	4.36e-03	0.19200	-0.124000	-1.46e-01	2.17e-03	2.94e-04
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX1	175	2.76e-04	2.56e-03	0.19200	0.176000	7.43e-02	5.57e-05	8.97e-02
REACTOME HIV INFECTION	216	1.43e-10	6.31e-09	0.19000	0.162000	-1.00e-01	4.00e-05	1.12e-02
REACTOME COMPLEX I BIOGENESIS	49	8.70e-03	4.65e-02	0.19000	0.067000	-1.78e-01	4.17e-01	3.10e-02
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	11	6.69e-01	7.87e-01	0.19000	0.123000	1.45e-01	4.78e-01	4.06e-01
REACTOME TERMINATION OF TRANSLESION DNA SYNTHESIS	31	7.03e-02	1.99e-01	0.19000	0.187000	-3.48e-02	7.19e-02	7.37e-01
REACTOME TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	14	5.59e-01	7.03e-01	0.19000	0.166000	9.12e-02	2.81e-01	5.55e-01
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	21	1.02e-01	2.53e-01	0.19000	0.135000	-1.33e-01	2.84e-01	2.91e-01
REACTOME PROGRAMMED CELL DEATH	194	2.62e-08	6.22e-07	0.19000	0.183000	-4.96e-02	1.10e-05	2.33e-01
REACTOME ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	20	1.42e-01	3.11e-01	0.18900	0.071700	-1.75e-01	5.79e-01	1.75e-01
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	16	4.19e-01	5.90e-01	0.18900	-0.047600	-1.83e-01	7.42e-01	2.05e-01
REACTOME GLYCOSAMINOGLYCAN METABOLISM	118	1.33e-02	6.27e-02	0.18900	0.116000	1.49e-01	2.90e-02	5.11e-03
REACTOME MRNA SPLICING	195	8.52e-10	3.24e-08	0.18900	0.129000	-1.38e-01	1.93e-03	8.58e-04
REACTOME BETA CATENIN INDEPENDENT WNT SIGNALING	144	4.70e-04	4.07e-03	0.18800	0.182000	4.86e-02	1.60e-04	3.14e-01
REACTOME DNA DOUBLE STRAND BREAK RESPONSE	39	9.86e-02	2.46e-01	0.18800	0.186000	3.09e-02	4.49e-02	7.38e-01
REACTOME INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	21	1.35e-01	3.02e-01	0.18800	-0.175000	6.87e-02	1.65e-01	5.85e-01
REACTOME GPCR LIGAND BINDING	439	8.75e-09	2.43e-07	0.18800	0.081700	1.69e-01	3.28e-03	1.13e-09
REACTOME HDACS DEACETYLATE HISTONES	29	9.87e-02	2.46e-01	0.18800	0.186000	-2.39e-02	8.25e-02	8.24e-01
REACTOME COMMON PATHWAY OF FIBRIN CLOT FORMATION	21	3.44e-01	5.24e-01	0.18800	-0.180000	-5.50e-02	1.54e-01	6.63e-01
REACTOME SIGNALING BY FGFR	85	4.19e-03	2.75e-02	0.18800	0.187000	1.62e-02	2.89e-03	7.96e-01
REACTOME ANDROGEN BIOSYNTHESIS	11	5.54e-01	6.99e-01	0.18700	-0.182000	-4.60e-02	2.97e-01	7.91e-01
REACTOME TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	37	6.52e-02	1.89e-01	0.18700	0.187000	-8.94e-03	4.89e-02	9.25e-01
REACTOME INHIBITION OF DNA RECOMBINATION AT TELOMERE	19	1.47e-01	3.19e-01	0.18700	0.094700	-1.61e-01	4.75e-01	2.25e-01
REACTOME RUNX3 REGULATES YAP1 MEDIATED TRANSCRIPTION	7	6.81e-01	7.97e-01	0.18600	0.182000	4.06e-02	4.05e-01	8.52e-01
REACTOME RHOU GTPASE CYCLE	37	2.23e-01	4.14e-01	0.18600	0.087500	1.64e-01	3.57e-01	8.35e-02
REACTOME PTEN REGULATION	134	2.47e-04	2.31e-03	0.18600	0.185000	1.97e-02	2.13e-04	6.93e-01
REACTOME PI3K AKT SIGNALING IN CANCER	103	2.75e-02	1.07e-01	0.18600	0.143000	1.19e-01	1.23e-02	3.66e-02
REACTOME RNA POLYMERASE I TRANSCRIPTION	45	4.23e-02	1.40e-01	0.18500	0.185000	-3.37e-03	3.14e-02	9.69e-01
REACTOME SYNTHESIS OF PE	12	6.54e-01	7.77e-01	0.18500	0.147000	1.12e-01	3.77e-01	5.02e-01
REACTOME UB SPECIFIC PROCESSING PROTEASES	149	3.64e-06	4.76e-05	0.18500	0.180000	-4.36e-02	1.53e-04	3.59e-01
REACTOME NUCLEOTIDE BIOSYNTHESIS	12	4.18e-01	5.90e-01	0.18500	0.011000	-1.84e-01	9.47e-01	2.69e-01
REACTOME SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	31	3.31e-01	5.10e-01	0.18400	0.150000	1.06e-01	1.47e-01	3.06e-01
REACTOME SIGNALING BY FLT3 FUSION PROTEINS	19	4.99e-01	6.56e-01	0.18400	0.154000	1.01e-01	2.45e-01	4.47e-01
REACTOME RNA POLYMERASE II PRE TRANSCRIPTION EVENTS	72	8.95e-04	7.21e-03	0.18400	0.159000	-9.24e-02	1.96e-02	1.75e-01
REACTOME FGFR2 ALTERNATIVE SPLICING	27	6.53e-02	1.89e-01	0.18400	0.143000	-1.16e-01	1.99e-01	2.98e-01
REACTOME EXTRA NUCLEAR ESTROGEN SIGNALING	74	4.78e-02	1.50e-01	0.18300	0.166000	7.88e-02	1.37e-02	2.41e-01
REACTOME HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR IN THE PRESENCE OF LIGAND	55	7.90e-03	4.38e-02	0.18300	0.174000	-5.83e-02	2.56e-02	4.54e-01
REACTOME PEROXISOMAL LIPID METABOLISM	28	1.53e-01	3.26e-01	0.18300	-0.000741	-1.83e-01	9.95e-01	9.37e-02
REACTOME APOPTOTIC EXECUTION PHASE	43	1.40e-01	3.07e-01	0.18300	0.172000	6.09e-02	5.06e-02	4.90e-01
REACTOME FANCONI ANEMIA PATHWAY	34	9.19e-02	2.35e-01	0.18300	0.182000	-8.76e-03	6.56e-02	9.30e-01
REACTOME ENDOGENOUS STEROLS	25	4.36e-01	6.03e-01	0.18200	-0.135000	-1.22e-01	2.42e-01	2.91e-01
REACTOME EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	3.16e-01	4.95e-01	0.18200	0.070000	1.68e-01	5.29e-01	1.31e-01
REACTOME RNA POLYMERASE I TRANSCRIPTION INITIATION	42	4.89e-02	1.52e-01	0.18200	0.181000	-1.48e-02	4.20e-02	8.68e-01
REACTOME SYNTHESIS OF DIPHTHAMIDE EEF2	8	4.52e-01	6.17e-01	0.18200	0.142000	-1.14e-01	4.87e-01	5.77e-01
REACTOME BASE EXCISION REPAIR	44	8.07e-02	2.18e-01	0.18200	0.180000	2.51e-02	3.88e-02	7.73e-01
REACTOME ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	41	2.16e-01	4.06e-01	0.18100	0.089700	1.57e-01	3.20e-01	8.10e-02
REACTOME TRAFFICKING OF AMPA RECEPTORS	29	1.88e-01	3.70e-01	0.18100	0.022800	1.80e-01	8.32e-01	9.39e-02
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	29	3.74e-01	5.55e-01	0.18100	0.144000	1.10e-01	1.79e-01	3.07e-01
REACTOME TRANSCRIPTIONAL REGULATION BY TP53	342	6.20e-10	2.48e-08	0.18100	0.181000	8.22e-03	8.88e-09	7.94e-01
REACTOME RIP MEDIATED NFKB ACTIVATION VIA ZBP1	16	2.06e-01	3.92e-01	0.18100	0.123000	-1.32e-01	3.94e-01	3.59e-01
REACTOME UNWINDING OF DNA	12	6.57e-01	7.79e-01	0.18100	0.150000	1.01e-01	3.68e-01	5.46e-01
REACTOME RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	7.05e-04	5.77e-03	0.18100	0.119000	-1.36e-01	7.77e-02	4.27e-02
REACTOME RNA POLYMERASE III TRANSCRIPTION	41	3.02e-02	1.13e-01	0.18100	0.171000	-5.74e-02	5.78e-02	5.25e-01
REACTOME UNFOLDED PROTEIN RESPONSE UPR	87	2.33e-04	2.20e-03	0.18000	0.148000	-1.04e-01	1.72e-02	9.50e-02
REACTOME GLYCEROPHOSPHOLIPID CATABOLISM	7	6.55e-01	7.77e-01	0.18000	-0.180000	-1.34e-02	4.10e-01	9.51e-01
REACTOME S PHASE	157	7.89e-07	1.18e-05	0.18000	0.164000	-7.42e-02	3.79e-04	1.09e-01
REACTOME VEGFR2 MEDIATED VASCULAR PERMEABILITY	26	1.72e-01	3.50e-01	0.18000	-0.007440	1.80e-01	9.48e-01	1.12e-01
REACTOME GPVI MEDIATED ACTIVATION CASCADE	34	2.36e-01	4.28e-01	0.18000	0.167000	6.69e-02	9.18e-02	5.00e-01
REACTOME SHC RELATED EVENTS TRIGGERED BY IGF1R	9	5.54e-01	6.99e-01	0.18000	0.180000	-1.60e-03	3.50e-01	9.93e-01
REACTOME FORMATION OF TC NER PRE INCISION COMPLEX	51	1.03e-02	5.26e-02	0.18000	0.163000	-7.55e-02	4.40e-02	3.51e-01
REACTOME IRAK4 DEFICIENCY TLR2 4	17	3.83e-01	5.63e-01	0.18000	-0.023200	-1.78e-01	8.69e-01	2.03e-01
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	259	1.49e-11	8.12e-10	0.17900	0.119000	-1.34e-01	9.44e-04	1.99e-04
REACTOME OXIDATIVE STRESS INDUCED SENESCENCE	65	1.03e-01	2.53e-01	0.17900	0.151000	9.66e-02	3.50e-02	1.78e-01
REACTOME ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	20	2.84e-01	4.77e-01	0.17900	0.179000	4.63e-03	1.65e-01	9.71e-01
REACTOME TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE	10	6.22e-01	7.53e-01	0.17900	-0.172000	-4.87e-02	3.46e-01	7.90e-01
REACTOME TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	55	3.58e-02	1.26e-01	0.17900	0.179000	1.04e-02	2.18e-02	8.94e-01
REACTOME GLYCOGEN STORAGE DISEASES	14	2.93e-01	4.84e-01	0.17900	0.165000	-6.98e-02	2.86e-01	6.51e-01
REACTOME INTERLEUKIN 37 SIGNALING	20	4.97e-01	6.56e-01	0.17900	-0.095400	-1.51e-01	4.60e-01	2.42e-01
REACTOME NEDDYLATION	230	4.12e-08	9.10e-07	0.17900	0.176000	-2.90e-02	4.01e-06	4.48e-01
REACTOME TRNA PROCESSING	98	8.24e-05	8.29e-04	0.17800	0.129000	-1.24e-01	2.76e-02	3.44e-02
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	23	4.82e-01	6.42e-01	0.17800	0.124000	1.28e-01	3.04e-01	2.87e-01
REACTOME TELOMERE EXTENSION BY TELOMERASE	22	2.88e-01	4.79e-01	0.17800	0.177000	2.04e-02	1.50e-01	8.69e-01
REACTOME METHYLATION	14	2.64e-01	4.58e-01	0.17800	0.111000	-1.40e-01	4.74e-01	3.66e-01
REACTOME SIGNAL ATTENUATION	10	7.24e-01	8.24e-01	0.17800	0.138000	1.12e-01	4.50e-01	5.38e-01
REACTOME CELLULAR RESPONSES TO STIMULI	706	8.45e-28	1.15e-25	0.17800	0.156000	-8.54e-02	1.40e-12	1.07e-04
REACTOME FCERI MEDIATED MAPK ACTIVATION	32	2.20e-01	4.09e-01	0.17800	0.172000	4.60e-02	9.30e-02	6.52e-01
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	52	2.98e-02	1.12e-01	0.17800	0.177000	-1.20e-02	2.71e-02	8.81e-01
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	77	6.87e-04	5.67e-03	0.17800	0.136000	-1.14e-01	3.92e-02	8.29e-02
REACTOME MATURATION OF SARS COV 2 SPIKE PROTEIN	35	2.44e-01	4.37e-01	0.17700	0.163000	6.91e-02	9.44e-02	4.79e-01
REACTOME SIGNALING BY NTRK3 TRKC	17	5.18e-01	6.74e-01	0.17700	0.161000	7.49e-02	2.52e-01	5.93e-01
REACTOME REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	11	3.76e-01	5.56e-01	0.17700	-0.081200	1.57e-01	6.41e-01	3.66e-01
REACTOME INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	18	4.81e-01	6.42e-01	0.17700	0.164000	6.64e-02	2.29e-01	6.26e-01
REACTOME RSK ACTIVATION	5	7.46e-01	8.37e-01	0.17600	0.010800	1.76e-01	9.67e-01	4.96e-01
REACTOME MEIOTIC RECOMBINATION	25	2.17e-01	4.07e-01	0.17600	0.176000	2.88e-03	1.28e-01	9.80e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	48	1.99e-02	8.59e-02	0.17600	0.166000	-5.83e-02	4.68e-02	4.85e-01
REACTOME SIGNALING BY INSULIN RECEPTOR	80	8.57e-02	2.26e-01	0.17600	0.125000	1.24e-01	5.37e-02	5.55e-02
REACTOME REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	11	7.13e-01	8.17e-01	0.17600	0.128000	1.20e-01	4.62e-01	4.90e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	2.34e-01	4.26e-01	0.17500	0.172000	-3.17e-02	1.82e-01	8.06e-01
REACTOME RESPONSE OF MTB TO PHAGOCYTOSIS	22	1.34e-01	3.01e-01	0.17500	0.106000	-1.39e-01	3.89e-01	2.59e-01
REACTOME HIV TRANSCRIPTION ELONGATION	38	3.00e-02	1.12e-01	0.17500	0.124000	-1.23e-01	1.86e-01	1.88e-01
REACTOME COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	65	1.93e-02	8.44e-02	0.17500	-0.175000	-1.42e-03	1.48e-02	9.84e-01
REACTOME HATS ACETYLATE HISTONES	70	1.10e-01	2.63e-01	0.17400	0.140000	1.04e-01	4.27e-02	1.33e-01
REACTOME FCERI MEDIATED CA 2 MOBILIZATION	30	2.89e-01	4.80e-01	0.17400	0.164000	5.85e-02	1.20e-01	5.79e-01
REACTOME METALLOPROTEASE DUBS	16	4.39e-01	6.07e-01	0.17400	0.172000	2.69e-02	2.34e-01	8.52e-01
REACTOME SARS COV 2 HOST INTERACTIONS	184	4.43e-06	5.62e-05	0.17400	0.019200	-1.73e-01	6.53e-01	5.26e-05
REACTOME PREGNENOLONE BIOSYNTHESIS	10	7.38e-01	8.32e-01	0.17400	-0.131000	-1.14e-01	4.73e-01	5.32e-01
REACTOME FORMATION OF INCISION COMPLEX IN GG NER	40	4.53e-02	1.46e-01	0.17400	0.166000	-5.03e-02	6.91e-02	5.82e-01
REACTOME SIGNAL AMPLIFICATION	33	2.61e-01	4.55e-01	0.17300	0.163000	5.81e-02	1.06e-01	5.64e-01
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	2.12e-01	4.00e-01	0.17200	0.172000	3.96e-04	1.28e-01	9.97e-01
REACTOME RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION	6	8.19e-01	8.87e-01	0.17200	0.148000	8.82e-02	5.30e-01	7.08e-01
REACTOME SIGNALING BY FGFR IN DISEASE	61	1.56e-01	3.28e-01	0.17200	0.136000	1.05e-01	6.55e-02	1.55e-01
REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	12	6.63e-01	7.83e-01	0.17200	0.151000	8.32e-02	3.66e-01	6.18e-01
REACTOME THE NLRP3 INFLAMMASOME	16	3.15e-01	4.95e-01	0.17200	0.037100	-1.68e-01	7.97e-01	2.44e-01
REACTOME ATTACHMENT OF GPI ANCHOR TO UPAR	7	6.66e-01	7.86e-01	0.17200	-0.004060	-1.72e-01	9.85e-01	4.31e-01
REACTOME TYROSINE CATABOLISM	5	8.53e-01	9.09e-01	0.17200	-0.143000	-9.59e-02	5.80e-01	7.10e-01
REACTOME CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	24	1.19e-01	2.76e-01	0.17200	0.130000	-1.12e-01	2.71e-01	3.41e-01
REACTOME METHIONINE SALVAGE PATHWAY	6	6.48e-01	7.74e-01	0.17200	0.167000	-3.83e-02	4.78e-01	8.71e-01
REACTOME HIV TRANSCRIPTION INITIATION	43	2.29e-02	9.46e-02	0.17200	0.136000	-1.04e-01	1.21e-01	2.38e-01
REACTOME SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	14	6.62e-01	7.83e-01	0.17100	-0.127000	-1.15e-01	4.10e-01	4.56e-01
REACTOME DEUBIQUITINATION	218	1.36e-06	1.93e-05	0.17100	0.171000	-9.91e-03	1.32e-05	8.01e-01
REACTOME IRON UPTAKE AND TRANSPORT	56	1.25e-02	6.02e-02	0.17100	0.160000	-6.01e-02	3.80e-02	4.37e-01
REACTOME PLATELET HOMEOSTASIS	82	9.15e-02	2.35e-01	0.17100	0.126000	1.16e-01	4.91e-02	6.94e-02
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	26	1.55e-01	3.28e-01	0.17100	0.167000	-3.84e-02	1.42e-01	7.34e-01
REACTOME POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	42	6.40e-02	1.86e-01	0.17100	0.169000	-2.03e-02	5.74e-02	8.20e-01
REACTOME TNFR1 INDUCED PROAPOPTOTIC SIGNALING	23	1.84e-01	3.66e-01	0.17000	0.046400	-1.64e-01	7.00e-01	1.74e-01
REACTOME SIGNALLING TO RAS	20	3.51e-01	5.33e-01	0.17000	0.169000	1.74e-02	1.90e-01	8.93e-01
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX	52	1.23e-02	6.02e-02	0.17000	0.144000	-9.11e-02	7.28e-02	2.56e-01
REACTOME PROCESSING OF INTRONLESS PRE MRNAS	19	2.53e-01	4.45e-01	0.17000	0.164000	-4.32e-02	2.15e-01	7.44e-01
REACTOME DNA METHYLATION	5	7.87e-01	8.67e-01	0.17000	0.029900	1.67e-01	9.08e-01	5.17e-01
REACTOME CELLULAR SENESCENCE	128	4.55e-03	2.92e-02	0.17000	0.163000	4.72e-02	1.44e-03	3.56e-01
REACTOME FGFR2B LIGAND BINDING AND ACTIVATION	10	6.55e-01	7.77e-01	0.17000	0.163000	4.71e-02	3.72e-01	7.96e-01
REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	111	3.10e-02	1.14e-01	0.16900	0.143000	9.06e-02	9.13e-03	9.90e-02
REACTOME CLASS A 1 RHODOPSIN LIKE RECEPTORS	307	1.80e-05	2.05e-04	0.16900	0.068800	1.55e-01	3.78e-02	3.10e-06
REACTOME SIGNALING BY RECEPTOR TYROSINE KINASES	506	8.68e-08	1.67e-06	0.16900	0.147000	8.26e-02	1.27e-08	1.44e-03
REACTOME GLYCOSPHINGOLIPID METABOLISM	38	2.65e-01	4.59e-01	0.16900	0.153000	7.25e-02	1.03e-01	4.39e-01
REACTOME PEPTIDE HORMONE BIOSYNTHESIS	13	3.53e-01	5.34e-01	0.16900	-0.151000	7.48e-02	3.45e-01	6.40e-01
REACTOME LIPID PARTICLE ORGANIZATION	6	8.37e-01	8.98e-01	0.16900	-0.100000	-1.36e-01	6.71e-01	5.65e-01
REACTOME CYTOPROTECTION BY HMOX1	59	6.68e-03	3.86e-02	0.16800	0.129000	-1.08e-01	8.73e-02	1.50e-01
REACTOME SEPARATION OF SISTER CHROMATIDS	178	3.23e-07	5.45e-06	0.16800	0.133000	-1.02e-01	2.11e-03	1.85e-02
REACTOME INWARDLY RECTIFYING K CHANNELS	35	3.27e-01	5.05e-01	0.16800	0.146000	8.39e-02	1.36e-01	3.91e-01
REACTOME GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	81	4.64e-03	2.96e-02	0.16800	0.165000	-2.92e-02	1.00e-02	6.50e-01
REACTOME RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	25	4.63e-01	6.25e-01	0.16800	0.142000	8.95e-02	2.19e-01	4.39e-01
REACTOME PECAM1 INTERACTIONS	12	6.99e-01	8.07e-01	0.16800	0.095100	1.38e-01	5.68e-01	4.08e-01
REACTOME BUTYROPHILIN BTN FAMILY INTERACTIONS	12	6.26e-01	7.56e-01	0.16700	0.158000	5.37e-02	3.42e-01	7.47e-01
REACTOME SIGNALING BY PDGF	57	1.97e-01	3.81e-01	0.16700	0.105000	1.30e-01	1.69e-01	8.93e-02
REACTOME P38MAPK EVENTS	13	3.73e-01	5.54e-01	0.16700	0.155000	-6.32e-02	3.35e-01	6.93e-01
REACTOME RHOV GTPASE CYCLE	36	3.12e-01	4.94e-01	0.16700	0.079000	1.47e-01	4.12e-01	1.27e-01
REACTOME ACETYLCHOLINE REGULATES INSULIN SECRETION	10	4.39e-01	6.07e-01	0.16700	-0.095800	1.36e-01	6.00e-01	4.55e-01
REACTOME RETINOID CYCLE DISEASE EVENTS	11	4.07e-01	5.83e-01	0.16700	-0.138000	9.30e-02	4.28e-01	5.93e-01
REACTOME SELECTIVE AUTOPHAGY	77	5.26e-03	3.24e-02	0.16600	0.162000	-3.86e-02	1.40e-02	5.58e-01
REACTOME PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	58	4.27e-02	1.41e-01	0.16600	0.166000	3.53e-03	2.84e-02	9.63e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	57	1.11e-02	5.56e-02	0.16600	0.146000	-7.97e-02	5.66e-02	2.98e-01
REACTOME ESR MEDIATED SIGNALING	157	7.20e-03	4.09e-02	0.16600	0.145000	8.17e-02	1.72e-03	7.73e-02
REACTOME ESTROGEN STIMULATED SIGNALING THROUGH PRKCZ	6	8.48e-01	9.05e-01	0.16600	0.117000	1.18e-01	6.20e-01	6.18e-01
REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION	23	5.32e-01	6.83e-01	0.16600	0.122000	1.12e-01	3.11e-01	3.51e-01
REACTOME ACYL CHAIN REMODELING OF CL	5	8.32e-01	8.96e-01	0.16500	-0.057700	-1.55e-01	8.23e-01	5.49e-01
REACTOME MEIOTIC SYNAPSIS	31	3.97e-01	5.75e-01	0.16500	0.088200	1.39e-01	3.95e-01	1.79e-01
REACTOME REGULATION OF INSULIN SECRETION	77	1.25e-01	2.86e-01	0.16500	0.116000	1.17e-01	7.85e-02	7.58e-02
REACTOME GPER1 SIGNALING	45	2.82e-01	4.76e-01	0.16500	0.098600	1.32e-01	2.52e-01	1.26e-01
REACTOME RND1 GTPASE CYCLE	41	3.17e-01	4.95e-01	0.16500	0.131000	9.91e-02	1.45e-01	2.72e-01
REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	9	6.16e-01	7.48e-01	0.16400	0.164000	8.81e-04	3.94e-01	9.96e-01
REACTOME NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY DVL INTERACTING PROTEINS	5	7.36e-01	8.31e-01	0.16400	-0.022300	1.62e-01	9.31e-01	5.29e-01
REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	5.32e-01	6.83e-01	0.16400	0.163000	1.66e-02	3.08e-01	9.17e-01
REACTOME EXTENSION OF TELOMERES	48	1.39e-01	3.07e-01	0.16300	0.159000	3.91e-02	5.71e-02	6.39e-01
REACTOME NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	25	1.39e-01	3.07e-01	0.16300	0.134000	-9.28e-02	2.45e-01	4.22e-01
REACTOME CONDENSATION OF PROPHASE CHROMOSOMES	11	4.96e-01	6.56e-01	0.16300	0.160000	-3.16e-02	3.58e-01	8.56e-01
REACTOME ERK MAPK TARGETS	20	2.86e-01	4.77e-01	0.16300	0.161000	-2.82e-02	2.14e-01	8.27e-01
REACTOME RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	19	5.98e-01	7.35e-01	0.16300	0.102000	1.27e-01	4.39e-01	3.39e-01
REACTOME CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	7.07e-01	8.12e-01	0.16300	0.074000	1.45e-01	6.71e-01	4.05e-01
REACTOME INTERLEUKIN 2 FAMILY SIGNALING	40	2.61e-01	4.55e-01	0.16300	-0.065200	-1.49e-01	4.75e-01	1.02e-01
REACTOME TRIGLYCERIDE BIOSYNTHESIS	12	5.03e-01	6.60e-01	0.16300	-0.162000	1.27e-02	3.31e-01	9.39e-01
REACTOME RESOLUTION OF D LOOP STRUCTURES	31	3.61e-01	5.42e-01	0.16200	0.148000	6.73e-02	1.54e-01	5.17e-01
REACTOME INTRACELLULAR SIGNALING BY SECOND MESSENGERS	297	3.79e-05	4.05e-04	0.16200	0.151000	5.97e-02	7.55e-06	7.65e-02
REACTOME DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	411	6.51e-08	1.31e-06	0.16200	0.158000	3.76e-02	3.84e-08	1.91e-01
REACTOME ESTROGEN DEPENDENT GENE EXPRESSION	87	6.28e-02	1.84e-01	0.16200	0.146000	7.04e-02	1.87e-02	2.56e-01
REACTOME UREA CYCLE	9	6.95e-01	8.05e-01	0.16100	0.036200	1.57e-01	8.51e-01	4.16e-01
REACTOME SUPPRESSION OF APOPTOSIS	7	7.51e-01	8.40e-01	0.16100	0.157000	3.41e-02	4.72e-01	8.76e-01
REACTOME SIGNALING BY ERBB2 ECD MUTANTS	15	4.68e-01	6.29e-01	0.16100	0.160000	3.39e-03	2.82e-01	9.82e-01
REACTOME INFLAMMASOMES	21	2.79e-01	4.72e-01	0.16100	0.028100	-1.58e-01	8.24e-01	2.10e-01
REACTOME RHOQ GTPASE CYCLE	57	4.77e-02	1.50e-01	0.16000	-0.005270	1.60e-01	9.45e-01	3.62e-02
REACTOME REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	5	8.59e-01	9.12e-01	0.16000	0.143000	7.32e-02	5.81e-01	7.77e-01
REACTOME EPIGENETIC REGULATION OF GENE EXPRESSION	82	1.72e-02	7.75e-02	0.16000	0.160000	5.94e-03	1.22e-02	9.26e-01
REACTOME MRNA CAPPING	28	1.14e-01	2.70e-01	0.16000	0.108000	-1.18e-01	3.23e-01	2.79e-01
REACTOME DAP12 SIGNALING	27	1.40e-01	3.07e-01	0.16000	0.142000	-7.41e-02	2.02e-01	5.05e-01
REACTOME CHOLESTEROL BIOSYNTHESIS	24	3.90e-01	5.68e-01	0.16000	0.038900	1.55e-01	7.41e-01	1.88e-01
REACTOME CELL CYCLE CHECKPOINTS	243	1.65e-08	4.27e-07	0.16000	0.137000	-8.23e-02	2.25e-04	2.70e-02
REACTOME PROTEIN FOLDING	94	5.11e-03	3.17e-02	0.16000	0.159000	-1.58e-02	7.75e-03	7.91e-01
REACTOME MOLECULES ASSOCIATED WITH ELASTIC FIBRES	37	2.95e-01	4.85e-01	0.15900	0.060100	1.47e-01	5.27e-01	1.21e-01
REACTOME HIV LIFE CYCLE	139	2.54e-05	2.81e-04	0.15900	0.113000	-1.12e-01	2.13e-02	2.27e-02
REACTOME MITOTIC METAPHASE AND ANAPHASE	221	8.77e-08	1.67e-06	0.15900	0.132000	-8.82e-02	7.27e-04	2.38e-02
REACTOME LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	19	4.22e-01	5.90e-01	0.15900	0.158000	1.61e-02	2.34e-01	9.03e-01
REACTOME TRANSCRIPTIONAL REGULATION BY E2F6	32	3.91e-01	5.69e-01	0.15800	0.140000	7.42e-02	1.71e-01	4.68e-01
REACTOME GLUCAGON TYPE LIGAND RECEPTORS	32	4.13e-01	5.87e-01	0.15800	0.135000	8.24e-02	1.87e-01	4.20e-01
REACTOME MET ACTIVATES PI3K AKT SIGNALING	6	7.60e-01	8.48e-01	0.15800	-0.012900	-1.57e-01	9.56e-01	5.05e-01
REACTOME NUCLEOTIDE EXCISION REPAIR	107	1.88e-03	1.38e-02	0.15800	0.155000	-2.86e-02	5.61e-03	6.09e-01
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	37	2.78e-01	4.71e-01	0.15700	-0.149000	-5.02e-02	1.16e-01	5.97e-01
REACTOME MITOTIC G2 G2 M PHASES	190	6.05e-06	7.50e-05	0.15700	0.150000	-4.59e-02	3.47e-04	2.75e-01
REACTOME SIGNALING BY RETINOIC ACID	41	1.61e-01	3.34e-01	0.15700	0.156000	1.52e-02	8.37e-02	8.67e-01
REACTOME O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	37	3.86e-01	5.66e-01	0.15700	0.091300	1.27e-01	3.37e-01	1.81e-01
REACTOME SIGNALING BY ALK	26	3.01e-01	4.90e-01	0.15600	0.156000	9.15e-03	1.68e-01	9.36e-01
REACTOME RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	22	4.43e-01	6.10e-01	0.15600	0.151000	3.92e-02	2.19e-01	7.50e-01
REACTOME ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	1.92e-01	3.74e-01	0.15600	0.086300	-1.30e-01	4.74e-01	2.80e-01
REACTOME AZATHIOPRINE ADME	22	3.36e-01	5.17e-01	0.15600	0.002460	-1.56e-01	9.84e-01	2.06e-01
REACTOME REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	78	4.27e-03	2.78e-02	0.15600	0.134000	-7.88e-02	4.03e-02	2.29e-01
REACTOME UBIQUINOL BIOSYNTHESIS	8	7.38e-01	8.32e-01	0.15500	0.151000	3.42e-02	4.58e-01	8.67e-01
REACTOME SYNAPTIC ADHESION LIKE MOLECULES	19	6.00e-01	7.35e-01	0.15500	0.133000	7.94e-02	3.15e-01	5.49e-01
REACTOME HYALURONAN UPTAKE AND DEGRADATION	12	7.12e-01	8.16e-01	0.15500	-0.071700	-1.37e-01	6.67e-01	4.10e-01
REACTOME RHO GTPASES ACTIVATE IQGAPS	31	4.20e-01	5.90e-01	0.15500	0.137000	7.29e-02	1.88e-01	4.82e-01
REACTOME LEISHMANIA INFECTION	156	2.21e-02	9.18e-02	0.15500	0.122000	9.55e-02	8.60e-03	3.95e-02
REACTOME TP53 REGULATES METABOLIC GENES	81	1.47e-02	6.81e-02	0.15500	0.154000	-1.32e-02	1.64e-02	8.38e-01
REACTOME DUAL INCISION IN TC NER	63	2.47e-02	9.93e-02	0.15500	0.151000	-3.54e-02	3.87e-02	6.27e-01
REACTOME CONSTITUTIVE SIGNALING BY EGFRVIII	15	4.35e-01	6.03e-01	0.15400	0.153000	-2.42e-02	3.06e-01	8.71e-01
REACTOME NR1H2 AND NR1H3 MEDIATED SIGNALING	46	6.73e-02	1.92e-01	0.15400	-0.035900	1.50e-01	6.74e-01	7.82e-02
REACTOME RHOBTB2 GTPASE CYCLE	22	2.35e-01	4.27e-01	0.15400	0.141000	-6.35e-02	2.54e-01	6.06e-01
REACTOME ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY	10	6.91e-01	8.04e-01	0.15400	0.035700	1.50e-01	8.45e-01	4.11e-01
REACTOME DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS	14	4.64e-01	6.26e-01	0.15400	-0.152000	2.30e-02	3.24e-01	8.82e-01
REACTOME DEFECTS IN COBALAMIN B12 METABOLISM	12	7.35e-01	8.31e-01	0.15400	0.129000	8.34e-02	4.38e-01	6.17e-01
REACTOME ION TRANSPORT BY P TYPE ATPASES	51	4.73e-02	1.50e-01	0.15400	-0.148000	4.15e-02	6.74e-02	6.08e-01
REACTOME SIGNALING BY FGFR2 IIIA TM	19	2.69e-01	4.63e-01	0.15300	0.084300	-1.28e-01	5.24e-01	3.34e-01
REACTOME INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	103	2.11e-03	1.51e-02	0.15300	0.147000	-4.31e-02	9.91e-03	4.49e-01
REACTOME PARASITE INFECTION	57	1.06e-01	2.58e-01	0.15300	0.151000	2.44e-02	4.90e-02	7.50e-01
REACTOME NUCLEAR IMPORT OF REV PROTEIN	32	1.76e-01	3.55e-01	0.15300	0.024700	-1.51e-01	8.09e-01	1.40e-01
REACTOME METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	6.31e-01	7.60e-01	0.15200	0.142000	5.55e-02	3.41e-01	7.10e-01
REACTOME PURINE SALVAGE	12	5.43e-01	6.92e-01	0.15200	0.151000	-1.45e-02	3.64e-01	9.31e-01
REACTOME EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	1.49e-01	3.21e-01	0.15200	0.051800	-1.43e-01	6.18e-01	1.69e-01
REACTOME ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	5.09e-01	6.66e-01	0.15100	0.127000	-8.33e-02	4.88e-01	6.48e-01
REACTOME SIGNALING BY ERBB2	49	1.89e-01	3.70e-01	0.15100	0.146000	4.07e-02	7.72e-02	6.22e-01
REACTOME SCAVENGING BY CLASS B RECEPTORS	6	7.16e-01	8.19e-01	0.15100	-0.148000	3.19e-02	5.30e-01	8.92e-01
REACTOME INTERLEUKIN 27 SIGNALING	11	7.57e-01	8.45e-01	0.15100	0.129000	7.84e-02	4.58e-01	6.52e-01
REACTOME ARACHIDONATE PRODUCTION FROM DAG	5	7.20e-01	8.21e-01	0.15100	-0.074300	1.31e-01	7.74e-01	6.11e-01
REACTOME NUCLEOTIDE CATABOLISM	35	4.25e-01	5.92e-01	0.15100	0.126000	8.27e-02	1.98e-01	3.97e-01
REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	26	4.66e-01	6.27e-01	0.15100	0.057200	1.39e-01	6.14e-01	2.19e-01
REACTOME TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	76	1.51e-02	6.87e-02	0.15000	0.146000	-3.40e-02	2.76e-02	6.08e-01
REACTOME MATURATION OF SARS COV 2 NUCLEOPROTEIN	15	4.51e-01	6.16e-01	0.15000	0.148000	-2.65e-02	3.22e-01	8.59e-01
REACTOME RHO GTPASES ACTIVATE WASPS AND WAVES	34	1.50e-01	3.21e-01	0.15000	0.145000	-3.73e-02	1.44e-01	7.07e-01
REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	23	4.47e-01	6.14e-01	0.14900	-0.146000	-3.33e-02	2.27e-01	7.82e-01
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	20	3.39e-01	5.19e-01	0.14900	0.146000	-3.17e-02	2.59e-01	8.06e-01
REACTOME SIGNALLING TO ERKS	34	3.78e-01	5.58e-01	0.14900	0.137000	5.73e-02	1.65e-01	5.63e-01
REACTOME PROTEIN REPAIR	6	8.47e-01	9.05e-01	0.14900	-0.061100	-1.36e-01	7.96e-01	5.65e-01
REACTOME SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	54	3.05e-01	4.92e-01	0.14900	0.105000	1.05e-01	1.81e-01	1.82e-01
REACTOME POLB DEPENDENT LONG PATCH BASE EXCISION REPAIR	7	7.76e-01	8.60e-01	0.14900	0.146000	2.75e-02	5.03e-01	9.00e-01
REACTOME REGULATION OF NF KAPPA B SIGNALING	17	3.71e-01	5.51e-01	0.14800	0.140000	-4.97e-02	3.18e-01	7.23e-01
REACTOME DETOXIFICATION OF REACTIVE OXYGEN SPECIES	34	1.07e-01	2.59e-01	0.14800	0.115000	-9.30e-02	2.45e-01	3.48e-01
REACTOME FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS	8	8.33e-01	8.96e-01	0.14800	-0.120000	-8.64e-02	5.58e-01	6.72e-01
REACTOME PHASE 2 PLATEAU PHASE	14	4.04e-01	5.81e-01	0.14700	-0.087300	1.19e-01	5.72e-01	4.41e-01
REACTOME MISMATCH REPAIR	15	7.17e-01	8.19e-01	0.14700	0.092200	1.15e-01	5.36e-01	4.40e-01
REACTOME GAP JUNCTION ASSEMBLY	36	4.07e-01	5.83e-01	0.14700	0.071600	1.29e-01	4.57e-01	1.81e-01
REACTOME G2 M DNA DAMAGE CHECKPOINT	55	7.02e-02	1.99e-01	0.14700	0.146000	-1.61e-02	6.03e-02	8.37e-01
REACTOME NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	36	1.70e-01	3.49e-01	0.14700	-0.019100	1.46e-01	8.42e-01	1.30e-01
REACTOME INTERLEUKIN 1 FAMILY SIGNALING	145	1.01e-04	1.01e-03	0.14700	0.081700	-1.22e-01	8.92e-02	1.10e-02
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	29	1.81e-01	3.61e-01	0.14700	0.136000	-5.66e-02	2.06e-01	5.98e-01
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	75	7.88e-03	4.38e-02	0.14600	0.105000	-1.02e-01	1.15e-01	1.28e-01
REACTOME CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	25	5.19e-01	6.74e-01	0.14600	0.062200	1.32e-01	5.90e-01	2.52e-01
REACTOME INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	1.86e-01	3.68e-01	0.14600	0.017800	-1.45e-01	8.56e-01	1.37e-01
REACTOME VXPX CARGO TARGETING TO CILIUM	20	2.77e-01	4.70e-01	0.14600	-0.101000	1.06e-01	4.36e-01	4.13e-01
REACTOME HOMOLOGY DIRECTED REPAIR	96	2.57e-02	1.02e-01	0.14600	0.145000	1.51e-02	1.41e-02	7.98e-01
REACTOME KERATAN SULFATE BIOSYNTHESIS	28	3.17e-01	4.96e-01	0.14600	0.005400	1.46e-01	9.61e-01	1.83e-01
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	62	2.70e-01	4.64e-01	0.14500	-0.107000	-9.90e-02	1.47e-01	1.78e-01
REACTOME PRE NOTCH PROCESSING IN GOLGI	18	6.41e-01	7.67e-01	0.14500	0.068200	1.28e-01	6.17e-01	3.46e-01
REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	23	5.79e-01	7.19e-01	0.14500	0.073500	1.25e-01	5.42e-01	2.98e-01
REACTOME DISEASES OF CARBOHYDRATE METABOLISM	30	3.79e-01	5.59e-01	0.14500	0.141000	3.50e-02	1.82e-01	7.40e-01
REACTOME PRE NOTCH EXPRESSION AND PROCESSING	59	1.06e-01	2.58e-01	0.14500	0.014000	1.44e-01	8.53e-01	5.54e-02
REACTOME CREB PHOSPHORYLATION	6	8.81e-01	9.26e-01	0.14400	-0.111000	-9.28e-02	6.39e-01	6.94e-01
REACTOME INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	45	6.71e-02	1.92e-01	0.14400	0.073000	-1.24e-01	3.97e-01	1.49e-01
REACTOME TRNA AMINOACYLATION	24	3.19e-01	4.97e-01	0.14400	0.020800	-1.43e-01	8.60e-01	2.27e-01
REACTOME SIGNALING BY MAPK MUTANTS	6	7.32e-01	8.28e-01	0.14400	0.139000	-3.70e-02	5.55e-01	8.75e-01
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	33	1.96e-01	3.79e-01	0.14400	0.027300	-1.41e-01	7.86e-01	1.60e-01
REACTOME TOLL LIKE RECEPTOR 9 TLR9 CASCADE	100	1.41e-02	6.61e-02	0.14400	0.144000	-3.95e-03	1.29e-02	9.46e-01
REACTOME SARS COV 1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS	16	3.77e-01	5.57e-01	0.14400	0.119000	-8.08e-02	4.10e-01	5.76e-01
REACTOME RHOB GTPASE CYCLE	65	5.55e-02	1.69e-01	0.14400	-0.011000	1.43e-01	8.78e-01	4.60e-02
REACTOME COSTIMULATION BY THE CD28 FAMILY	64	1.85e-01	3.68e-01	0.14300	0.132000	5.57e-02	6.76e-02	4.41e-01
REACTOME MEIOSIS	55	2.86e-01	4.77e-01	0.14300	0.123000	7.44e-02	1.16e-01	3.40e-01
REACTOME TRANSPORT OF RCBL WITHIN THE BODY	8	7.37e-01	8.32e-01	0.14300	0.010900	1.43e-01	9.57e-01	4.84e-01
REACTOME DEFECTS IN VITAMIN AND COFACTOR METABOLISM	20	6.58e-01	7.79e-01	0.14300	0.111000	8.99e-02	3.88e-01	4.86e-01
REACTOME EPHRIN SIGNALING	17	6.02e-01	7.37e-01	0.14300	0.137000	4.05e-02	3.27e-01	7.73e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING	5	8.94e-01	9.31e-01	0.14300	0.121000	7.57e-02	6.39e-01	7.69e-01
REACTOME TELOMERE MAINTENANCE	61	7.37e-02	2.05e-01	0.14300	0.143000	-6.71e-03	5.42e-02	9.28e-01
REACTOME POTENTIAL THERAPEUTICS FOR SARS	92	7.20e-02	2.02e-01	0.14300	0.136000	4.44e-02	2.46e-02	4.62e-01
REACTOME FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	81	1.21e-01	2.80e-01	0.14200	0.131000	5.43e-02	4.11e-02	3.98e-01
REACTOME LATE SARS COV 2 INFECTION EVENTS	67	1.16e-01	2.71e-01	0.14200	0.139000	2.91e-02	4.93e-02	6.81e-01
REACTOME LATE ENDOSOMAL MICROAUTOPHAGY	33	2.51e-01	4.43e-01	0.14200	0.141000	-5.82e-03	1.59e-01	9.54e-01
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	91	3.85e-02	1.32e-01	0.14200	0.141000	1.53e-02	2.03e-02	8.01e-01
REACTOME RND2 GTPASE CYCLE	40	4.50e-01	6.16e-01	0.14100	0.104000	9.56e-02	2.54e-01	2.96e-01
REACTOME DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	27	2.33e-01	4.25e-01	0.14100	0.131000	-5.26e-02	2.38e-01	6.36e-01
REACTOME CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	10	8.17e-01	8.87e-01	0.14100	0.109000	8.94e-02	5.51e-01	6.24e-01
REACTOME MYD88 INDEPENDENT TLR4 CASCADE	103	4.21e-03	2.76e-02	0.14100	0.132000	-5.00e-02	2.08e-02	3.80e-01
REACTOME INTERLEUKIN 1 PROCESSING	9	7.18e-01	8.20e-01	0.14100	-0.140000	-1.12e-02	4.65e-01	9.54e-01
REACTOME TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	1.49e-01	3.20e-01	0.14100	0.063700	-1.26e-01	5.20e-01	2.05e-01
REACTOME TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	38	1.06e-01	2.58e-01	0.14100	0.113000	-8.43e-02	2.29e-01	3.68e-01
REACTOME GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	30	3.15e-01	4.95e-01	0.14100	-0.004780	-1.41e-01	9.64e-01	1.82e-01
REACTOME ACTIVATION OF BH3 ONLY PROTEINS	30	4.22e-01	5.90e-01	0.14100	0.135000	3.99e-02	2.01e-01	7.05e-01
REACTOME EPHB MEDIATED FORWARD SIGNALING	41	1.31e-01	2.96e-01	0.14000	0.136000	-3.63e-02	1.33e-01	6.88e-01
REACTOME TELOMERE C STRAND LAGGING STRAND SYNTHESIS	32	3.38e-01	5.19e-01	0.14000	0.139000	2.04e-02	1.74e-01	8.42e-01
REACTOME SIGNALING BY TGFB FAMILY MEMBERS	119	2.40e-02	9.75e-02	0.14000	0.137000	2.93e-02	9.62e-03	5.80e-01
REACTOME PD 1 SIGNALING	21	3.95e-01	5.73e-01	0.14000	0.016200	-1.39e-01	8.97e-01	2.68e-01
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	81	7.44e-02	2.07e-01	0.14000	0.138000	2.63e-02	3.21e-02	6.82e-01
REACTOME MTOR SIGNALLING	40	4.11e-01	5.87e-01	0.14000	0.121000	7.00e-02	1.84e-01	4.43e-01
REACTOME O LINKED GLYCOSYLATION	105	3.87e-02	1.32e-01	0.14000	0.030200	1.37e-01	5.93e-01	1.54e-02
REACTOME ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	23	5.85e-01	7.25e-01	0.14000	0.125000	6.37e-02	3.01e-01	5.97e-01
REACTOME HDR THROUGH MMEJ ALT NHEJ	11	6.42e-01	7.68e-01	0.14000	0.140000	-3.87e-03	4.23e-01	9.82e-01
REACTOME SULFUR AMINO ACID METABOLISM	26	3.07e-01	4.92e-01	0.13900	0.137000	-2.38e-02	2.27e-01	8.34e-01
REACTOME FORMATION OF THE EARLY ELONGATION COMPLEX	32	1.55e-01	3.28e-01	0.13900	0.099100	-9.73e-02	3.32e-01	3.41e-01
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	30	2.71e-01	4.64e-01	0.13900	0.138000	-1.69e-02	1.91e-01	8.72e-01
REACTOME ADHERENS JUNCTIONS INTERACTIONS	28	5.81e-01	7.21e-01	0.13900	0.106000	8.98e-02	3.33e-01	4.11e-01
REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	11	6.33e-01	7.61e-01	0.13900	0.138000	-1.04e-02	4.27e-01	9.52e-01
REACTOME SIGNALING BY NOTCH	180	2.44e-03	1.72e-02	0.13800	0.137000	1.74e-02	1.48e-03	6.88e-01
REACTOME HSF1 DEPENDENT TRANSACTIVATION	37	1.23e-01	2.82e-01	0.13800	0.112000	-8.11e-02	2.39e-01	3.93e-01
REACTOME RHOBTB GTPASE CYCLE	34	1.61e-01	3.34e-01	0.13800	0.123000	-6.27e-02	2.15e-01	5.27e-01
REACTOME MIRO GTPASE CYCLE	8	8.35e-01	8.97e-01	0.13800	0.063000	1.23e-01	7.58e-01	5.48e-01
REACTOME AUTOPHAGY	142	9.55e-03	4.98e-02	0.13800	0.137000	1.92e-02	4.94e-03	6.93e-01
REACTOME DNA DOUBLE STRAND BREAK REPAIR	126	1.24e-02	6.02e-02	0.13800	0.137000	1.12e-02	7.76e-03	8.28e-01
REACTOME CELLULAR RESPONSE TO HEAT STRESS	96	4.81e-03	3.05e-02	0.13800	0.115000	-7.59e-02	5.17e-02	1.99e-01
REACTOME OPIOID SIGNALLING	88	1.74e-01	3.52e-01	0.13800	0.112000	8.01e-02	6.94e-02	1.94e-01
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	53	5.44e-02	1.67e-01	0.13800	0.071100	-1.18e-01	3.70e-01	1.38e-01
REACTOME DAP12 INTERACTIONS	37	1.45e-01	3.15e-01	0.13800	0.055800	-1.26e-01	5.57e-01	1.86e-01
REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	19	4.09e-01	5.84e-01	0.13700	0.133000	-3.35e-02	3.14e-01	8.00e-01
REACTOME SIGNALING BY GPCR	666	6.41e-08	1.31e-06	0.13700	0.047300	1.29e-01	3.68e-02	1.31e-08
REACTOME INTERLEUKIN 23 SIGNALING	9	8.40e-01	9.00e-01	0.13700	0.108000	8.43e-02	5.74e-01	6.61e-01
REACTOME NEGATIVE REGULATION OF MET ACTIVITY	20	3.66e-01	5.46e-01	0.13700	0.129000	-4.80e-02	3.20e-01	7.10e-01
REACTOME MAPK FAMILY SIGNALING CASCADES	311	2.06e-05	2.32e-04	0.13700	0.137000	9.79e-03	3.27e-05	7.66e-01
REACTOMEMATURATION OF SARS COV 1 NUCLEOPROTEIN	11	5.79e-01	7.19e-01	0.13700	0.129000	-4.55e-02	4.58e-01	7.94e-01
REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	9	6.96e-01	8.05e-01	0.13700	-0.137000	9.07e-03	4.77e-01	9.62e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	19	3.80e-01	5.59e-01	0.13700	0.127000	-5.13e-02	3.38e-01	6.98e-01
REACTOME RHOH GTPASE CYCLE	35	2.63e-01	4.58e-01	0.13700	0.137000	-1.82e-03	1.61e-01	9.85e-01
REACTOME SIGNALING BY ALK IN CANCER	51	9.37e-02	2.38e-01	0.13700	0.133000	-3.29e-02	1.01e-01	6.85e-01
REACTOME G ALPHA Q SIGNALLING EVENTS	205	1.25e-02	6.02e-02	0.13700	0.066300	1.20e-01	1.02e-01	3.11e-03
REACTOME NICOTINATE METABOLISM	29	5.76e-01	7.18e-01	0.13700	0.106000	8.64e-02	3.23e-01	4.20e-01
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	6.60e-01	7.81e-01	0.13700	0.070900	1.17e-01	5.83e-01	3.65e-01
REACTOME AGGREPHAGY	41	1.26e-01	2.87e-01	0.13700	0.127000	-5.07e-02	1.60e-01	5.74e-01
REACTOME G ALPHA I SIGNALLING EVENTS	303	1.31e-04	1.27e-03	0.13700	0.028100	1.34e-01	4.00e-01	6.24e-05
REACTOME SIGNALING BY INTERLEUKINS	432	4.08e-11	2.09e-09	0.13600	0.099900	-9.30e-02	3.61e-04	9.06e-04
REACTOME INTERLEUKIN 10 SIGNALING	43	2.84e-01	4.77e-01	0.13600	-0.030000	-1.33e-01	7.33e-01	1.31e-01
REACTOME RAB GEFS EXCHANGE GTP FOR GDP ON RABS	80	8.75e-02	2.29e-01	0.13600	0.025100	1.34e-01	6.98e-01	3.82e-02
REACTOME COLLAGEN DEGRADATION	61	6.26e-02	1.84e-01	0.13600	-0.132000	3.21e-02	7.51e-02	6.65e-01
REACTOME HEME SIGNALING	46	4.13e-01	5.87e-01	0.13500	0.077600	1.10e-01	3.63e-01	1.95e-01
REACTOME SODIUM PROTON EXCHANGERS	7	7.00e-01	8.08e-01	0.13500	-0.057900	1.22e-01	7.91e-01	5.77e-01
REACTOME SURFACTANT METABOLISM	27	5.36e-01	6.85e-01	0.13500	0.124000	5.35e-02	2.65e-01	6.30e-01
REACTOME MRNA EDITING	10	5.95e-01	7.33e-01	0.13400	0.065800	-1.17e-01	7.18e-01	5.21e-01
REACTOME STRIATED MUSCLE CONTRACTION	35	3.89e-01	5.67e-01	0.13400	-0.130000	-3.51e-02	1.84e-01	7.19e-01
REACTOME CHROMATIN MODIFYING ENZYMES	183	3.54e-02	1.25e-01	0.13400	0.104000	8.44e-02	1.48e-02	4.89e-02
REACTOME COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	20	5.28e-01	6.81e-01	0.13400	0.015500	1.33e-01	9.04e-01	3.02e-01
REACTOME TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	71	2.40e-01	4.31e-01	0.13400	0.115000	6.84e-02	9.27e-02	3.19e-01
REACTOME TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	2.14e-01	4.03e-01	0.13400	0.077100	-1.09e-01	4.72e-01	3.07e-01
REACTOME HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	64	7.49e-02	2.08e-01	0.13400	0.133000	-1.70e-02	6.61e-02	8.14e-01
REACTOME HYALURONAN METABOLISM	17	7.37e-01	8.32e-01	0.13400	0.090000	9.90e-02	5.20e-01	4.80e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE	5	8.95e-01	9.31e-01	0.13400	-0.055700	-1.22e-01	8.29e-01	6.38e-01
REACTOME SARS COV 2 MODULATES AUTOPHAGY	11	7.05e-01	8.11e-01	0.13300	-0.015100	-1.33e-01	9.31e-01	4.46e-01
REACTOME SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	7.82e-01	8.66e-01	0.13300	0.110000	7.52e-02	4.92e-01	6.39e-01
REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	14	4.93e-01	6.52e-01	0.13300	0.117000	-6.28e-02	4.47e-01	6.84e-01
REACTOME INFECTIOUS DISEASE	843	4.52e-19	3.89e-17	0.13300	0.113000	-7.06e-02	2.44e-08	4.78e-04
REACTOME SIGNALING BY NUCLEAR RECEPTORS	230	8.72e-03	4.65e-02	0.13300	0.118000	6.20e-02	2.08e-03	1.05e-01
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	120	1.15e-01	2.70e-01	0.13300	-0.082600	-1.04e-01	1.18e-01	4.83e-02
REACTOME INACTIVATION OF CDC42 AND RAC1	8	7.83e-01	8.66e-01	0.13300	0.018700	1.32e-01	9.27e-01	5.19e-01
REACTOME SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	7	7.45e-01	8.37e-01	0.13300	-0.130000	2.52e-02	5.50e-01	9.08e-01
REACTOME HS GAG BIOSYNTHESIS	28	4.92e-01	6.52e-01	0.13300	0.039200	1.27e-01	7.19e-01	2.46e-01
REACTOME SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	4.53e-01	6.18e-01	0.13300	0.103000	-8.37e-02	4.90e-01	5.75e-01
REACTOME SYNTHESIS OF UDP N ACETYL GLUCOSAMINE	7	8.83e-01	9.27e-01	0.13200	0.081100	1.04e-01	7.10e-01	6.35e-01
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	30	3.03e-01	4.90e-01	0.13200	-0.019200	1.30e-01	8.55e-01	2.17e-01
REACTOME VIRAL MESSENGER RNA SYNTHESIS	42	1.73e-01	3.52e-01	0.13100	0.027600	-1.28e-01	7.57e-01	1.50e-01
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	291	4.16e-05	4.39e-04	0.13100	0.131000	-1.59e-03	1.16e-04	9.63e-01
REACTOME DARPP 32 EVENTS	24	3.59e-01	5.40e-01	0.13100	0.127000	-3.14e-02	2.80e-01	7.90e-01
REACTOME TBC RABGAPS	40	3.00e-01	4.89e-01	0.13100	0.130000	1.67e-02	1.54e-01	8.55e-01
REACTOME REACTIONS SPECIFIC TO THE COMPLEX N GLYCAN SYNTHESIS PATHWAY	10	6.06e-01	7.39e-01	0.13100	-0.069000	1.11e-01	7.05e-01	5.42e-01
REACTOME SHC1 EVENTS IN EGFR SIGNALING	14	7.19e-01	8.20e-01	0.13100	0.123000	4.38e-02	4.24e-01	7.76e-01
REACTOME DEFECTS IN BIOTIN BTN METABOLISM	8	8.71e-01	9.18e-01	0.13100	0.084800	9.96e-02	6.78e-01	6.26e-01
REACTOME MITOCHONDRIAL BIOGENESIS	68	7.87e-02	2.14e-01	0.13000	0.130000	-1.24e-02	6.40e-02	8.60e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	42	3.41e-01	5.21e-01	0.13000	0.126000	3.31e-02	1.57e-01	7.10e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	18	4.04e-01	5.81e-01	0.13000	0.076000	-1.06e-01	5.77e-01	4.38e-01
REACTOME COLLAGEN FORMATION	88	2.13e-02	8.99e-02	0.13000	-0.123000	3.99e-02	4.52e-02	5.17e-01
REACTOME KETONE BODY METABOLISM	9	6.85e-01	7.98e-01	0.13000	-0.032600	1.26e-01	8.66e-01	5.14e-01
REACTOME SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	49	4.05e-01	5.82e-01	0.13000	-0.110000	-6.87e-02	1.83e-01	4.05e-01
REACTOME MUSCARINIC ACETYLCHOLINE RECEPTORS	5	8.29e-01	8.94e-01	0.12900	-0.128000	1.54e-02	6.19e-01	9.52e-01
REACTOME INTERLEUKIN 17 SIGNALING	66	8.72e-02	2.29e-01	0.12900	0.128000	-1.37e-02	7.13e-02	8.48e-01
REACTOME PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	5.95e-01	7.33e-01	0.12900	0.127000	2.32e-02	3.39e-01	8.61e-01
REACTOME SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	25	4.23e-01	5.91e-01	0.12900	-0.129000	4.43e-03	2.66e-01	9.69e-01
REACTOME ASPARTATE AND ASPARAGINE METABOLISM	11	6.00e-01	7.35e-01	0.12800	0.115000	-5.71e-02	5.09e-01	7.43e-01
REACTOME KERATAN SULFATE KERATIN METABOLISM	34	4.54e-01	6.18e-01	0.12800	0.039800	1.22e-01	6.88e-01	2.18e-01
REACTOME HDR THROUGH SINGLE STRAND ANNEALING SSA	36	2.29e-01	4.20e-01	0.12800	0.124000	-3.15e-02	1.97e-01	7.44e-01
REACTOME MAP2K AND MAPK ACTIVATION	38	4.16e-01	5.89e-01	0.12800	-0.039900	-1.22e-01	6.70e-01	1.94e-01
REACTOME RIBAVIRIN ADME	11	7.85e-01	8.67e-01	0.12800	0.120000	4.49e-02	4.92e-01	7.97e-01
REACTOME C TYPE LECTIN RECEPTORS CLRS	135	1.37e-03	1.04e-02	0.12800	0.098700	-8.13e-02	4.77e-02	1.03e-01
REACTOME SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	71	3.13e-01	4.94e-01	0.12800	0.096100	8.41e-02	1.61e-01	2.20e-01
REACTOME NOD1 2 SIGNALING PATHWAY	33	2.01e-01	3.86e-01	0.12800	0.077900	-1.01e-01	4.39e-01	3.15e-01
REACTOME ARACHIDONIC ACID METABOLISM	56	3.00e-01	4.89e-01	0.12700	-0.045800	-1.19e-01	5.54e-01	1.24e-01
REACTOME FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	11	8.37e-01	8.98e-01	0.12700	0.088200	9.16e-02	6.12e-01	5.99e-01
REACTOME METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	118	1.03e-01	2.53e-01	0.12700	0.114000	5.72e-02	3.31e-02	2.83e-01
REACTOME DISEASES OF MISMATCH REPAIR MMR	5	9.20e-01	9.50e-01	0.12700	0.077700	1.01e-01	7.64e-01	6.97e-01
REACTOME STIMULI SENSING CHANNELS	100	2.32e-02	9.54e-02	0.12700	-0.125000	2.14e-02	3.06e-02	7.12e-01
REACTOME RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	10	6.32e-01	7.60e-01	0.12700	0.112000	-5.98e-02	5.40e-01	7.43e-01
REACTOME HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	41	2.95e-01	4.85e-01	0.12700	0.126000	9.45e-03	1.62e-01	9.17e-01
REACTOME RHOBTB1 GTPASE CYCLE	22	3.95e-01	5.73e-01	0.12700	0.120000	-4.15e-02	3.32e-01	7.36e-01
REACTOME AMYLOID FIBER FORMATION	50	9.07e-02	2.34e-01	0.12600	0.081600	-9.66e-02	3.18e-01	2.37e-01
REACTOME PLATELET SENSITIZATION BY LDL	17	4.40e-01	6.07e-01	0.12600	0.088600	-9.02e-02	5.27e-01	5.20e-01
REACTOME SIGNALING BY CSF1 M CSF IN MYELOID CELLS	30	2.85e-01	4.77e-01	0.12600	0.120000	-4.03e-02	2.56e-01	7.02e-01
REACTOME PROLACTIN RECEPTOR SIGNALING	15	7.64e-01	8.51e-01	0.12600	-0.063700	-1.09e-01	6.69e-01	4.65e-01
REACTOME NRAGE SIGNALS DEATH THROUGH JNK	53	1.67e-01	3.45e-01	0.12600	-0.126000	6.93e-03	1.12e-01	9.30e-01
REACTOME DISEASES OF DNA REPAIR	49	2.27e-01	4.18e-01	0.12500	0.125000	4.87e-03	1.30e-01	9.53e-01
REACTOME INTERLEUKIN 15 SIGNALING	13	6.95e-01	8.05e-01	0.12500	0.124000	1.30e-02	4.39e-01	9.35e-01
REACTOME FOXO MEDIATED TRANSCRIPTION	64	1.35e-01	3.02e-01	0.12500	0.125000	-5.58e-04	8.49e-02	9.94e-01
REACTOME MITOCHONDRIAL CALCIUM ION TRANSPORT	20	7.28e-01	8.26e-01	0.12400	0.098100	7.66e-02	4.48e-01	5.53e-01
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	23	6.83e-01	7.98e-01	0.12400	0.069900	1.03e-01	5.62e-01	3.92e-01
REACTOME RHO GTPASES ACTIVATE CIT	19	5.68e-01	7.12e-01	0.12400	0.124000	5.24e-03	3.48e-01	9.68e-01
REACTOME POLYMERASE SWITCHING	13	6.46e-01	7.72e-01	0.12400	0.010400	-1.24e-01	9.48e-01	4.39e-01
REACTOME TNF SIGNALING	53	8.55e-02	2.26e-01	0.12400	0.083700	-9.16e-02	2.92e-01	2.49e-01
REACTOME NERVOUS SYSTEM DEVELOPMENT	547	1.40e-10	6.31e-09	0.12400	0.113000	-5.02e-02	5.66e-06	4.44e-02
REACTOME SIGNALING BY NOTCH1 T 7 9 NOTCH1 M1580 K2555 TRANSLOCATION MUTANT	7	8.83e-01	9.27e-01	0.12400	0.109000	5.90e-02	6.18e-01	7.87e-01
REACTOME PIWI INTERACTING RNA PIRNA BIOGENESIS	29	6.38e-01	7.64e-01	0.12400	-0.095100	-7.93e-02	3.76e-01	4.60e-01
REACTOME CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	9	8.15e-01	8.86e-01	0.12400	0.119000	3.32e-02	5.36e-01	8.63e-01
REACTOME RHO GTPASES ACTIVATE ROCKS	19	7.46e-01	8.37e-01	0.12300	0.095400	7.80e-02	4.71e-01	5.56e-01
REACTOME TOLL LIKE RECEPTOR CASCADES	157	4.89e-03	3.07e-02	0.12300	0.122000	-1.45e-02	8.14e-03	7.54e-01
REACTOME NS1 MEDIATED EFFECTS ON HOST PATHWAYS	39	2.38e-01	4.29e-01	0.12300	0.026700	-1.20e-01	7.73e-01	1.95e-01
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	11	6.79e-01	7.96e-01	0.12300	-0.121000	1.96e-02	4.86e-01	9.11e-01
REACTOME GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	34	5.99e-01	7.35e-01	0.12300	0.085700	8.81e-02	3.87e-01	3.74e-01
REACTOME NETRIN 1 SIGNALING	48	4.15e-01	5.88e-01	0.12300	0.111000	5.31e-02	1.85e-01	5.25e-01
REACTOME INDUCTION OF CELL CELL FUSION	12	6.16e-01	7.48e-01	0.12200	-0.044000	1.14e-01	7.92e-01	4.93e-01
REACTOME SIGNALLING TO P38 VIA RIT AND RIN	5	8.54e-01	9.09e-01	0.12200	0.122000	-6.09e-03	6.36e-01	9.81e-01
REACTOME PEPTIDE LIGAND BINDING RECEPTORS	188	3.81e-02	1.31e-01	0.12200	0.057200	1.08e-01	1.76e-01	1.06e-02
REACTOME DNA REPAIR	270	5.44e-04	4.64e-03	0.12200	0.122000	7.63e-03	5.56e-04	8.29e-01
REACTOME SENSORY PROCESSING OF SOUND	69	3.59e-01	5.40e-01	0.12200	-0.088300	-8.44e-02	2.04e-01	2.26e-01
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	46	1.91e-01	3.73e-01	0.12200	0.119000	-2.53e-02	1.61e-01	7.66e-01
REACTOME ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	59	7.28e-02	2.03e-01	0.12200	-0.074600	9.65e-02	3.21e-01	2.00e-01
REACTOME PI METABOLISM	78	2.62e-01	4.55e-01	0.12200	0.058000	1.07e-01	3.76e-01	1.02e-01
REACTOME CHROMOSOME MAINTENANCE	83	4.95e-02	1.54e-01	0.12200	0.119000	-2.70e-02	6.14e-02	6.70e-01
REACTOME SIGNALING BY MRAS COMPLEX MUTANTS	7	8.95e-01	9.31e-01	0.12100	0.067500	1.01e-01	7.57e-01	6.44e-01
REACTOME DNA STRAND ELONGATION	31	5.43e-01	6.92e-01	0.12100	0.113000	4.23e-02	2.75e-01	6.84e-01
REACTOME GLUTATHIONE CONJUGATION	33	3.60e-01	5.42e-01	0.12100	0.006460	-1.21e-01	9.49e-01	2.30e-01
REACTOME CELL CYCLE MITOTIC	473	4.24e-08	9.25e-07	0.12100	0.117000	-3.03e-02	1.26e-05	2.58e-01
REACTOME PYRIMIDINE CATABOLISM	12	8.39e-01	8.99e-01	0.12000	0.078100	9.16e-02	6.40e-01	5.83e-01
REACTOME PENTOSE PHOSPHATE PATHWAY	12	7.03e-01	8.10e-01	0.12000	0.120000	-1.63e-03	4.72e-01	9.92e-01
REACTOME METABOLISM OF STEROIDS	147	1.06e-01	2.58e-01	0.12000	-0.099200	-6.74e-02	3.78e-02	1.58e-01
REACTOME SMOOTH MUSCLE CONTRACTION	40	5.39e-01	6.88e-01	0.12000	-0.066400	-9.99e-02	4.67e-01	2.74e-01
REACTOME SEMAPHORIN INTERACTIONS	61	3.75e-01	5.55e-01	0.12000	0.103000	6.11e-02	1.64e-01	4.09e-01
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	38	5.35e-01	6.85e-01	0.11900	-0.105000	-5.73e-02	2.64e-01	5.41e-01
REACTOME METABOLISM OF AMINE DERIVED HORMONES	17	6.05e-01	7.39e-01	0.11900	-0.119000	3.89e-03	3.95e-01	9.78e-01
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	671	6.48e-13	4.08e-11	0.11900	0.086700	-8.17e-02	1.23e-04	2.98e-04
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	30	3.87e-01	5.66e-01	0.11900	0.013700	-1.18e-01	8.97e-01	2.63e-01
REACTOME RAC2 GTPASE CYCLE	79	3.12e-01	4.94e-01	0.11900	0.069700	9.62e-02	2.84e-01	1.39e-01
REACTOME TIGHT JUNCTION INTERACTIONS	27	5.83e-01	7.24e-01	0.11900	0.036600	1.13e-01	7.42e-01	3.09e-01
REACTOME RHOT1 GTPASE CYCLE	5	9.19e-01	9.50e-01	0.11900	0.053600	1.06e-01	8.36e-01	6.82e-01
REACTOME RHOJ GTPASE CYCLE	50	3.13e-01	4.94e-01	0.11900	0.021000	1.17e-01	7.97e-01	1.54e-01
REACTOME RHO GTPASES ACTIVATE KTN1	11	7.72e-01	8.57e-01	0.11800	0.117000	1.93e-02	5.03e-01	9.12e-01
REACTOME BASIGIN INTERACTIONS	24	6.35e-01	7.62e-01	0.11800	0.111000	4.02e-02	3.47e-01	7.33e-01
REACTOME METABOLISM OF NUCLEOTIDES	92	4.36e-02	1.43e-01	0.11800	0.115000	-2.68e-02	5.70e-02	6.56e-01
REACTOME ACTIVATION OF MATRIX METALLOPROTEINASES	30	3.99e-01	5.76e-01	0.11800	-0.117000	1.22e-02	2.68e-01	9.08e-01
REACTOME AQUAPORIN MEDIATED TRANSPORT	51	4.94e-01	6.54e-01	0.11700	0.078100	8.77e-02	3.35e-01	2.79e-01
REACTOME POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	3.71e-01	5.51e-01	0.11700	0.048400	-1.07e-01	6.69e-01	3.45e-01
REACTOME SPHINGOLIPID METABOLISM	79	3.00e-01	4.89e-01	0.11700	0.100000	6.03e-02	1.23e-01	3.54e-01
REACTOME CA DEPENDENT EVENTS	35	4.84e-01	6.43e-01	0.11700	0.029600	1.13e-01	7.62e-01	2.46e-01
REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	7	8.59e-01	9.12e-01	0.11700	0.024600	1.14e-01	9.10e-01	6.00e-01
REACTOME BLOOD GROUP SYSTEMS BIOSYNTHESIS	21	6.77e-01	7.95e-01	0.11700	-0.040000	-1.10e-01	7.51e-01	3.83e-01
REACTOME BIOTIN TRANSPORT AND METABOLISM	10	8.44e-01	9.03e-01	0.11600	0.047800	1.06e-01	7.93e-01	5.61e-01
REACTOME MET PROMOTES CELL MOTILITY	41	3.43e-01	5.24e-01	0.11600	-0.116000	-4.64e-03	1.98e-01	9.59e-01
REACTOME INTERFERON ALPHA BETA SIGNALING	70	7.82e-02	2.14e-01	0.11600	0.042600	-1.08e-01	5.38e-01	1.18e-01
REACTOME RUNX2 REGULATES BONE DEVELOPMENT	29	4.50e-01	6.16e-01	0.11600	0.116000	-2.19e-03	2.80e-01	9.84e-01
REACTOME CELL CYCLE	594	1.57e-08	4.20e-07	0.11600	0.115000	-1.70e-02	1.72e-06	4.79e-01
REACTOME HDL REMODELING	10	7.51e-01	8.40e-01	0.11600	-0.116000	7.28e-03	5.26e-01	9.68e-01
REACTOME OVARIAN TUMOR DOMAIN PROTEASES	35	3.44e-01	5.24e-01	0.11600	0.115000	-1.53e-02	2.40e-01	8.76e-01
REACTOME AMINO ACIDS REGULATE MTORC1	50	4.36e-01	6.03e-01	0.11600	0.105000	4.85e-02	1.98e-01	5.53e-01
REACTOME NONHOMOLOGOUS END JOINING NHEJ	29	6.67e-01	7.86e-01	0.11600	0.093600	6.80e-02	3.83e-01	5.26e-01
REACTOME GLUCOSE METABOLISM	87	1.06e-01	2.58e-01	0.11500	-0.003860	-1.15e-01	9.50e-01	6.29e-02
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	19	7.69e-01	8.56e-01	0.11500	-0.068500	-9.26e-02	6.05e-01	4.85e-01
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	356	1.14e-05	1.35e-04	0.11500	0.112000	-2.61e-02	2.84e-04	3.98e-01
REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	134	7.49e-03	4.23e-02	0.11500	-0.104000	4.83e-02	3.72e-02	3.34e-01
REACTOME RUNX3 REGULATES CDKN1A TRANSCRIPTION	7	8.02e-01	8.78e-01	0.11500	0.022300	-1.12e-01	9.19e-01	6.07e-01
REACTOME REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	53	4.36e-01	6.03e-01	0.11500	0.051500	1.02e-01	5.17e-01	1.98e-01
REACTOME METAL ION SLC TRANSPORTERS	23	7.40e-01	8.33e-01	0.11400	0.075600	8.57e-02	5.30e-01	4.77e-01
REACTOME INTRA GOLGI TRAFFIC	43	5.30e-01	6.83e-01	0.11400	0.098900	5.70e-02	2.62e-01	5.18e-01
REACTOME MITOTIC SPINDLE CHECKPOINT	105	1.79e-02	7.97e-02	0.11400	0.094300	-6.43e-02	9.49e-02	2.55e-01
REACTOME PROTON COUPLED MONOCARBOXYLATE TRANSPORT	6	8.85e-01	9.28e-01	0.11400	0.025400	1.11e-01	9.14e-01	6.37e-01
REACTOME TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	50	1.55e-01	3.28e-01	0.11400	0.098400	-5.70e-02	2.29e-01	4.86e-01
REACTOME TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	109	1.79e-02	7.97e-02	0.11400	0.099000	-5.55e-02	7.39e-02	3.17e-01
REACTOME NCAM1 INTERACTIONS	41	2.98e-01	4.88e-01	0.11300	-0.017000	1.12e-01	8.51e-01	2.15e-01
REACTOME SYNTHESIS OF KETONE BODIES	8	8.14e-01	8.86e-01	0.11300	-0.000424	1.13e-01	9.98e-01	5.80e-01
REACTOME SYNDECAN INTERACTIONS	26	5.34e-01	6.84e-01	0.11300	-0.112000	-5.79e-03	3.21e-01	9.59e-01
REACTOME EGFR TRANSACTIVATION BY GASTRIN	9	8.92e-01	9.30e-01	0.11200	0.083700	7.50e-02	6.64e-01	6.97e-01
REACTOME MET ACTIVATES RAP1 AND RAC1	11	7.12e-01	8.16e-01	0.11200	0.109000	-2.53e-02	5.30e-01	8.85e-01
REACTOME TNFR1 MEDIATED CERAMIDE PRODUCTION	5	8.30e-01	8.95e-01	0.11200	0.092500	-6.35e-02	7.20e-01	8.06e-01
REACTOME METABOLISM OF FOLATE AND PTERINES	16	5.44e-01	6.92e-01	0.11200	0.078400	-8.03e-02	5.87e-01	5.78e-01
REACTOME RA BIOSYNTHESIS PATHWAY	22	5.98e-01	7.35e-01	0.11200	0.112000	8.34e-03	3.64e-01	9.46e-01
REACTOME DISORDERS OF TRANSMEMBRANE TRANSPORTERS	167	1.94e-03	1.41e-02	0.11200	0.070100	-8.74e-02	1.18e-01	5.13e-02
REACTOME SARS COV 2 INFECTION	274	8.26e-05	8.29e-04	0.11200	0.045900	-1.02e-01	1.90e-01	3.62e-03
REACTOME SARS COV 2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES	113	1.57e-01	3.30e-01	0.11200	-0.041300	-1.04e-01	4.48e-01	5.63e-02
REACTOME DSCAM INTERACTIONS	11	7.35e-01	8.31e-01	0.11100	0.014300	-1.10e-01	9.35e-01	5.27e-01
REACTOME COPII MEDIATED VESICLE TRANSPORT	66	2.05e-01	3.91e-01	0.11100	-0.002650	-1.11e-01	9.70e-01	1.20e-01
REACTOME TELOMERE C STRAND SYNTHESIS INITIATION	11	6.81e-01	7.97e-01	0.11100	0.097200	-5.27e-02	5.77e-01	7.62e-01
REACTOME TRYPTOPHAN CATABOLISM	12	7.30e-01	8.27e-01	0.11000	-0.110000	7.79e-03	5.09e-01	9.63e-01
REACTOME ION CHANNEL TRANSPORT	172	6.93e-03	3.99e-02	0.11000	-0.108000	2.22e-02	1.49e-02	6.15e-01
REACTOME RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS	9	7.29e-01	8.26e-01	0.11000	0.058300	-9.29e-02	7.62e-01	6.29e-01
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	16	5.60e-01	7.04e-01	0.10900	0.074800	-7.99e-02	6.04e-01	5.80e-01
REACTOME IRS ACTIVATION	5	9.42e-01	9.67e-01	0.10900	0.076200	7.85e-02	7.68e-01	7.61e-01
REACTOME NUCLEAR PORE COMPLEX NPC DISASSEMBLY	34	3.44e-01	5.24e-01	0.10900	0.035800	-1.03e-01	7.18e-01	2.98e-01
REACTOME TRANSCRIPTIONAL REGULATION BY SMALL RNAS	45	2.16e-01	4.06e-01	0.10900	0.052800	-9.53e-02	5.40e-01	2.69e-01
REACTOME NUCLEAR ENVELOPE NE REASSEMBLY	73	9.82e-02	2.46e-01	0.10900	0.102000	-3.88e-02	1.33e-01	5.66e-01
REACTOME RECEPTOR MEDIATED MITOPHAGY	10	8.19e-01	8.87e-01	0.10900	0.017500	1.07e-01	9.24e-01	5.57e-01
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	1280	1.79e-10	7.51e-09	0.10900	0.106000	2.48e-02	1.61e-10	1.34e-01
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	18	5.31e-01	6.83e-01	0.10900	0.065400	-8.68e-02	6.31e-01	5.24e-01
REACTOME M PHASE	332	2.97e-05	3.22e-04	0.10800	0.101000	-4.03e-02	1.62e-03	2.06e-01
REACTOME CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	7.18e-01	8.20e-01	0.10800	-0.048300	9.69e-02	7.91e-01	5.96e-01
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	83	1.88e-01	3.70e-01	0.10800	-0.107000	-1.51e-02	9.21e-02	8.13e-01
REACTOME ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	6	8.10e-01	8.83e-01	0.10800	-0.079400	7.28e-02	7.36e-01	7.58e-01
REACTOME SARS COV INFECTIONS	385	1.67e-06	2.32e-05	0.10800	0.078200	-7.41e-02	8.37e-03	1.25e-02
REACTOME TAK1 DEPENDENT IKK AND NF KAPPA B ACTIVATION	41	2.39e-01	4.31e-01	0.10800	0.079900	-7.21e-02	3.76e-01	4.24e-01
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	20	7.95e-01	8.72e-01	0.10700	0.077200	7.43e-02	5.50e-01	5.65e-01
REACTOME O LINKED GLYCOSYLATION OF MUCINS	60	1.87e-01	3.68e-01	0.10700	-0.024100	1.04e-01	7.47e-01	1.63e-01
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	30	5.66e-01	7.10e-01	0.10600	0.104000	1.64e-02	3.22e-01	8.76e-01
REACTOME RAC3 GTPASE CYCLE	83	3.57e-01	5.38e-01	0.10600	0.054500	9.06e-02	3.90e-01	1.54e-01
REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	24	6.54e-01	7.77e-01	0.10600	0.022600	1.03e-01	8.48e-01	3.82e-01
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	48	5.03e-01	6.60e-01	0.10500	0.040700	9.73e-02	6.26e-01	2.43e-01
REACTOME G ALPHA S SIGNALLING EVENTS	153	1.19e-01	2.77e-01	0.10500	0.041500	9.62e-02	3.75e-01	3.99e-02
REACTOME RHO GTPASES ACTIVATE PKNS	33	6.95e-01	8.05e-01	0.10500	0.079000	6.87e-02	4.32e-01	4.95e-01
REACTOME INNATE IMMUNE SYSTEM	989	2.96e-09	9.69e-08	0.10400	-0.005770	-1.04e-01	7.58e-01	2.68e-08
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	17	7.97e-01	8.73e-01	0.10400	0.044100	9.42e-02	7.53e-01	5.01e-01
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	20	6.67e-01	7.86e-01	0.10400	-0.006800	-1.04e-01	9.58e-01	4.22e-01
REACTOME SIGNALING BY FGFR4 IN DISEASE	11	8.87e-01	9.29e-01	0.10400	0.079500	6.66e-02	6.48e-01	7.02e-01
REACTOME OTHER INTERLEUKIN SIGNALING	24	4.98e-01	6.56e-01	0.10400	0.038700	-9.61e-02	7.43e-01	4.15e-01
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	114	5.75e-02	1.75e-01	0.10300	-0.101000	1.84e-02	6.12e-02	7.35e-01
REACTOME HDMS DEMETHYLATE HISTONES	17	8.30e-01	8.95e-01	0.10300	0.062200	8.20e-02	6.57e-01	5.58e-01
REACTOME ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA	9	8.57e-01	9.12e-01	0.10300	0.020000	1.01e-01	9.17e-01	6.00e-01
REACTOME NUCLEOTIDE SALVAGE	21	5.55e-01	6.99e-01	0.10300	0.035100	-9.65e-02	7.80e-01	4.44e-01
REACTOME G PROTEIN MEDIATED EVENTS	52	3.49e-01	5.30e-01	0.10300	0.004180	1.02e-01	9.58e-01	2.01e-01
REACTOME L1CAM INTERACTIONS	112	3.06e-01	4.92e-01	0.10200	-0.078900	-6.49e-02	1.49e-01	2.36e-01
REACTOME HCMV LATE EVENTS	52	3.57e-01	5.38e-01	0.10200	0.102000	5.23e-03	2.04e-01	9.48e-01
REACTOME INTERFERON SIGNALING	190	3.62e-03	2.43e-02	0.10200	0.051000	-8.78e-02	2.25e-01	3.68e-02
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	52	2.75e-01	4.69e-01	0.10000	0.097300	-2.38e-02	2.25e-01	7.67e-01
REACTOME GAP JUNCTION TRAFFICKING AND REGULATION	49	5.69e-01	7.13e-01	0.09980	0.048000	8.75e-02	5.61e-01	2.89e-01
REACTOME CELL CELL JUNCTION ORGANIZATION	57	5.17e-01	6.74e-01	0.09960	0.047000	8.78e-02	5.39e-01	2.51e-01
REACTOME REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	83	1.36e-01	3.02e-01	0.09960	0.097300	-2.13e-02	1.25e-01	7.38e-01
REACTOME MICRORNA MIRNA BIOGENESIS	25	7.14e-01	8.18e-01	0.09890	0.093300	3.27e-02	4.19e-01	7.77e-01
REACTOME NON INTEGRIN MEMBRANE ECM INTERACTIONS	55	2.01e-01	3.87e-01	0.09880	-0.078400	6.02e-02	3.15e-01	4.40e-01
REACTOME RHO GTPASES ACTIVATE FORMINS	131	3.27e-02	1.18e-01	0.09880	0.092300	-3.54e-02	6.81e-02	4.84e-01
REACTOME INTEGRIN SIGNALING	27	7.49e-01	8.39e-01	0.09880	-0.083700	-5.25e-02	4.52e-01	6.37e-01
REACTOME METABOLISM OF INGESTED SEMET SEC MESEC INTO H2SE	7	8.17e-01	8.87e-01	0.09880	0.080900	-5.67e-02	7.11e-01	7.95e-01
REACTOME GAB1 SIGNALOSOME	17	7.87e-01	8.67e-01	0.09850	0.094300	2.82e-02	5.01e-01	8.40e-01
REACTOME PYRUVATE METABOLISM	29	7.53e-01	8.42e-01	0.09830	0.075100	6.35e-02	4.84e-01	5.54e-01
REACTOME RAB REGULATION OF TRAFFICKING	109	3.06e-01	4.92e-01	0.09820	0.049400	8.49e-02	3.73e-01	1.26e-01
REACTOME ASPARAGINE N LINKED GLYCOSYLATION	296	6.75e-04	5.63e-03	0.09820	0.093700	-2.93e-02	5.51e-03	3.85e-01
REACTOME DEADENYLATION OF MRNA	22	5.28e-01	6.81e-01	0.09820	0.064800	-7.38e-02	5.99e-01	5.49e-01
REACTOME TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	3.07e-01	4.92e-01	0.09800	0.075500	-6.24e-02	4.03e-01	4.89e-01
REACTOME PROCESSING OF SMDT1	13	7.01e-01	8.09e-01	0.09740	-0.084900	4.79e-02	5.96e-01	7.65e-01
REACTOME DEFECTIVE F9 ACTIVATION	5	8.69e-01	9.18e-01	0.09730	-0.079700	5.58e-02	7.58e-01	8.29e-01
REACTOME ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	16	8.39e-01	8.99e-01	0.09710	0.085500	4.60e-02	5.54e-01	7.50e-01
REACTOME NEUTROPHIL DEGRANULATION	455	2.70e-05	2.97e-04	0.09690	0.024600	-9.37e-02	3.68e-01	6.02e-04
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	67	1.86e-01	3.68e-01	0.09660	0.090000	-3.51e-02	2.02e-01	6.20e-01
REACTOME ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	7.15e-01	8.18e-01	0.09640	0.094500	-1.94e-02	5.26e-01	8.96e-01
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	24	5.94e-01	7.33e-01	0.09560	0.017500	-9.40e-02	8.82e-01	4.25e-01
REACTOME ION HOMEOSTASIS	52	2.59e-01	4.54e-01	0.09550	-0.084200	4.50e-02	2.94e-01	5.74e-01
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	19	6.06e-01	7.40e-01	0.09540	0.048100	-8.24e-02	7.17e-01	5.34e-01
REACTOME GLYCOGEN METABOLISM	22	7.85e-01	8.67e-01	0.09530	0.085600	4.19e-02	4.87e-01	7.34e-01
REACTOME SEMA4D IN SEMAPHORIN SIGNALING	24	8.04e-01	8.79e-01	0.09510	0.072000	6.20e-02	5.41e-01	5.99e-01
REACTOME INTERFERON GAMMA SIGNALING	88	9.16e-02	2.35e-01	0.09500	0.070800	-6.34e-02	2.51e-01	3.04e-01
REACTOME RESOLUTION OF SISTER CHROMATID COHESION	115	4.87e-02	1.52e-01	0.09500	0.080400	-5.06e-02	1.36e-01	3.48e-01
REACTOME SUMOYLATION OF SUMOYLATION PROTEINS	33	4.48e-01	6.15e-01	0.09500	0.034700	-8.84e-02	7.30e-01	3.79e-01
REACTOME GLYCOLYSIS	68	3.15e-01	4.95e-01	0.09480	-0.005400	-9.47e-02	9.39e-01	1.77e-01
REACTOME ECM PROTEOGLYCANS	73	2.19e-01	4.09e-01	0.09450	-0.093300	1.52e-02	1.68e-01	8.22e-01
REACTOME PROTEIN METHYLATION	14	7.80e-01	8.64e-01	0.09420	-0.000377	-9.42e-02	9.98e-01	5.42e-01
REACTOME SYNTHESIS OF PG	8	8.89e-01	9.29e-01	0.09420	0.016500	9.27e-02	9.36e-01	6.50e-01
REACTOME CALCINEURIN ACTIVATES NFAT	9	8.92e-01	9.30e-01	0.09400	0.089900	2.74e-02	6.41e-01	8.87e-01
REACTOME FATTY ACYL COA BIOSYNTHESIS	36	6.87e-01	8.01e-01	0.09360	0.083400	4.26e-02	3.87e-01	6.58e-01
REACTOME POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	24	5.47e-01	6.92e-01	0.09270	0.078300	-4.96e-02	5.07e-01	6.74e-01
REACTOME ADAPTIVE IMMUNE SYSTEM	721	1.50e-06	2.10e-05	0.09250	0.091900	-1.03e-02	2.49e-05	6.36e-01
REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	88	4.76e-01	6.36e-01	0.09180	0.060600	6.90e-02	3.26e-01	2.63e-01
REACTOME RAF ACTIVATION	32	7.28e-01	8.26e-01	0.09180	0.042400	8.13e-02	6.78e-01	4.26e-01
REACTOME DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	14	7.04e-01	8.10e-01	0.09130	0.060300	-6.86e-02	6.96e-01	6.57e-01
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	37	4.25e-01	5.92e-01	0.09110	0.082400	-3.89e-02	3.86e-01	6.82e-01
REACTOME NFE2L2 REGULATING ANTI OXIDANT DETOXIFICATION ENZYMES	17	6.53e-01	7.77e-01	0.09110	0.066100	-6.26e-02	6.37e-01	6.55e-01
REACTOME LAMININ INTERACTIONS	28	5.44e-01	6.92e-01	0.09100	-0.029200	8.62e-02	7.89e-01	4.30e-01
REACTOME TRAF6 MEDIATED NF KB ACTIVATION	23	5.65e-01	7.09e-01	0.09070	0.065100	-6.31e-02	5.89e-01	6.01e-01
REACTOME LAGGING STRAND SYNTHESIS	19	7.47e-01	8.37e-01	0.09020	0.090100	5.41e-03	4.97e-01	9.67e-01
REACTOME DISEASES OF BASE EXCISION REPAIR	5	8.97e-01	9.32e-01	0.08960	0.083100	-3.35e-02	7.48e-01	8.97e-01
REACTOME DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	38	7.24e-01	8.24e-01	0.08910	-0.074100	-4.95e-02	4.29e-01	5.98e-01
REACTOME DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B	7	8.48e-01	9.05e-01	0.08840	-0.059900	6.50e-02	7.84e-01	7.66e-01
REACTOME EARLY SARS COV 2 INFECTION EVENTS	34	7.28e-01	8.26e-01	0.08830	0.078900	3.96e-02	4.26e-01	6.89e-01
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	15	8.06e-01	8.80e-01	0.08820	0.007060	8.79e-02	9.62e-01	5.55e-01
REACTOME LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX	5	8.92e-01	9.30e-01	0.08810	-0.072900	4.95e-02	7.78e-01	8.48e-01
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	291	1.84e-03	1.35e-02	0.08810	-0.078700	3.95e-02	2.07e-02	2.46e-01
REACTOME MEMBRANE TRAFFICKING	600	3.91e-03	2.59e-02	0.08800	0.079400	3.79e-02	8.74e-04	1.12e-01
REACTOME RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	47	3.63e-01	5.43e-01	0.08720	0.077200	-4.05e-02	3.60e-01	6.31e-01
REACTOME MITOTIC TELOPHASE CYTOKINESIS	10	7.97e-01	8.73e-01	0.08670	-0.065200	5.71e-02	7.21e-01	7.54e-01
REACTOME SYNTHESIS OF PC	27	6.57e-01	7.79e-01	0.08640	0.003310	-8.63e-02	9.76e-01	4.37e-01
REACTOME INTERLEUKIN 35 SIGNALLING	12	8.19e-01	8.87e-01	0.08610	0.085600	-1.01e-02	6.08e-01	9.52e-01
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	62	2.78e-01	4.71e-01	0.08500	-0.041200	7.43e-02	5.74e-01	3.12e-01
REACTOME COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	52	6.75e-01	7.93e-01	0.08490	0.069100	4.93e-02	3.89e-01	5.39e-01
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	23	6.13e-01	7.46e-01	0.08410	0.054200	-6.43e-02	6.53e-01	5.93e-01
REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	7.92e-01	8.71e-01	0.08410	-0.080900	2.28e-02	6.13e-01	8.87e-01
REACTOME INSULIN PROCESSING	24	8.46e-01	9.05e-01	0.08360	0.059200	5.91e-02	6.16e-01	6.16e-01
REACTOME WAX AND PLASMALOGEN BIOSYNTHESIS	5	9.64e-01	9.82e-01	0.08320	0.068000	4.79e-02	7.92e-01	8.53e-01
REACTOME RHO GTPASE EFFECTORS	247	2.80e-02	1.08e-01	0.08290	0.082700	-4.85e-03	2.51e-02	8.95e-01
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	51	4.20e-01	5.90e-01	0.08280	0.080400	-1.99e-02	3.21e-01	8.06e-01
REACTOME NUCLEAR ENVELOPE BREAKDOWN	50	4.72e-01	6.34e-01	0.08240	0.008270	-8.20e-02	9.19e-01	3.16e-01
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	14	8.07e-01	8.80e-01	0.08230	0.081700	-1.05e-02	5.97e-01	9.46e-01
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	120	1.17e-01	2.74e-01	0.08200	0.028500	-7.68e-02	5.89e-01	1.46e-01
REACTOME CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	25	6.25e-01	7.55e-01	0.08170	-0.036400	7.31e-02	7.52e-01	5.27e-01
REACTOME LYSINE CATABOLISM	12	8.37e-01	8.98e-01	0.08100	0.010100	-8.04e-02	9.52e-01	6.30e-01
REACTOME CTLA4 INHIBITORY SIGNALING	21	7.93e-01	8.71e-01	0.08090	0.079800	1.29e-02	5.27e-01	9.19e-01
REACTOME MET ACTIVATES RAS SIGNALING	11	8.08e-01	8.81e-01	0.08020	0.058900	-5.44e-02	7.35e-01	7.55e-01
REACTOME ROS AND RNS PRODUCTION IN PHAGOCYTES	34	6.33e-01	7.61e-01	0.08000	0.079900	-3.66e-03	4.20e-01	9.70e-01
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	101	1.44e-01	3.13e-01	0.07990	-0.057400	5.56e-02	3.19e-01	3.34e-01
REACTOME DISEASES OF IMMUNE SYSTEM	29	6.29e-01	7.59e-01	0.07950	0.021000	-7.67e-02	8.45e-01	4.75e-01
REACTOME RHOC GTPASE CYCLE	68	2.90e-01	4.80e-01	0.07950	-0.068600	4.02e-02	3.28e-01	5.67e-01
REACTOME SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	21	8.70e-01	9.18e-01	0.07930	-0.045900	-6.46e-02	7.16e-01	6.08e-01
REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	11	8.88e-01	9.29e-01	0.07880	0.078000	1.08e-02	6.54e-01	9.50e-01
REACTOME HS GAG DEGRADATION	19	8.80e-01	9.26e-01	0.07870	0.066000	4.29e-02	6.18e-01	7.46e-01
REACTOME DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	64	3.07e-01	4.92e-01	0.07860	-0.048600	6.17e-02	5.01e-01	3.93e-01
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	35	5.90e-01	7.29e-01	0.07820	0.076000	-1.82e-02	4.36e-01	8.52e-01
REACTOME WNT MEDIATED ACTIVATION OF DVL	8	8.63e-01	9.14e-01	0.07790	-0.054300	5.59e-02	7.90e-01	7.84e-01
REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	13	7.88e-01	8.67e-01	0.07790	-0.055900	5.43e-02	7.27e-01	7.35e-01
REACTOME G ALPHA 12 13 SIGNALLING EVENTS	74	3.16e-01	4.95e-01	0.07750	-0.023700	7.38e-02	7.24e-01	2.72e-01
REACTOME PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	8.62e-01	9.14e-01	0.07710	-0.076400	1.01e-02	6.61e-01	9.54e-01
REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	13	8.21e-01	8.88e-01	0.07690	0.073600	-2.22e-02	6.46e-01	8.90e-01
REACTOME VITAMIN B2 RIBOFLAVIN METABOLISM	7	8.86e-01	9.28e-01	0.07680	0.064700	-4.14e-02	7.67e-01	8.50e-01
REACTOME SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	42	7.85e-01	8.67e-01	0.07600	-0.054000	-5.35e-02	5.45e-01	5.49e-01
REACTOME PHENYLALANINE AND TYROSINE METABOLISM	10	9.42e-01	9.67e-01	0.07550	0.044300	6.12e-02	8.08e-01	7.38e-01
REACTOME BETA OXIDATION OF PRISTANOYL COA	9	9.45e-01	9.69e-01	0.07510	-0.064400	-3.86e-02	7.38e-01	8.41e-01
REACTOME INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	198	1.01e-01	2.50e-01	0.07420	0.074100	-3.94e-03	7.19e-02	9.24e-01
REACTOME ESTABLISHMENT OF SISTER CHROMATID COHESION	8	9.57e-01	9.77e-01	0.07420	-0.056000	-4.87e-02	7.84e-01	8.11e-01
REACTOME HCMV INFECTION	94	3.86e-01	5.66e-01	0.07420	0.073900	5.99e-03	2.15e-01	9.20e-01
REACTOME RHOF GTPASE CYCLE	40	7.91e-01	8.70e-01	0.07420	0.041700	6.13e-02	6.48e-01	5.02e-01
REACTOME RND3 GTPASE CYCLE	41	7.69e-01	8.55e-01	0.07380	0.034000	6.55e-02	7.06e-01	4.68e-01
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	75	6.18e-01	7.50e-01	0.07370	0.065500	3.39e-02	3.27e-01	6.12e-01
REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	116	4.80e-01	6.41e-01	0.07360	-0.065100	-3.43e-02	2.26e-01	5.24e-01
REACTOME AURKA ACTIVATION BY TPX2	68	4.14e-01	5.88e-01	0.07270	0.070800	-1.64e-02	3.12e-01	8.15e-01
REACTOME MITOTIC PROPHASE	77	3.10e-01	4.94e-01	0.07150	0.057300	-4.28e-02	3.85e-01	5.16e-01
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	41	8.13e-01	8.86e-01	0.07110	0.051600	4.88e-02	5.67e-01	5.88e-01
REACTOME ER TO GOLGI ANTEROGRADE TRANSPORT	152	1.62e-01	3.35e-01	0.07050	0.014700	-6.90e-02	7.55e-01	1.42e-01
REACTOME METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	32	7.40e-01	8.33e-01	0.07050	-0.004120	-7.04e-02	9.68e-01	4.91e-01
REACTOME COPI MEDIATED ANTEROGRADE TRANSPORT	101	2.26e-01	4.17e-01	0.07000	0.051800	-4.71e-02	3.68e-01	4.13e-01
REACTOME PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	14	9.34e-01	9.61e-01	0.06970	0.050800	4.77e-02	7.42e-01	7.57e-01
REACTOME CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	5.76e-01	7.18e-01	0.06950	0.011400	-6.85e-02	8.91e-01	4.07e-01
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT	235	8.50e-02	2.25e-01	0.06900	-0.068600	7.24e-03	6.97e-02	8.48e-01
REACTOME INSULIN RECEPTOR RECYCLING	29	6.92e-01	8.04e-01	0.06900	0.024100	-6.47e-02	8.22e-01	5.47e-01
REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	9	9.58e-01	9.78e-01	0.06860	0.043500	5.30e-02	8.21e-01	7.83e-01
REACTOME UPTAKE AND ACTIONS OF BACTERIAL TOXINS	29	7.16e-01	8.19e-01	0.06830	0.016000	-6.64e-02	8.82e-01	5.36e-01
REACTOME CDC42 GTPASE CYCLE	142	1.42e-01	3.11e-01	0.06780	-0.042500	5.29e-02	3.82e-01	2.76e-01
REACTOME TIE2 SIGNALING	18	8.26e-01	8.92e-01	0.06780	0.009960	-6.71e-02	9.42e-01	6.22e-01
REACTOME RAC1 GTPASE CYCLE	168	1.12e-01	2.66e-01	0.06760	-0.059400	3.24e-02	1.84e-01	4.69e-01
REACTOME PHOSPHOLIPID METABOLISM	191	7.83e-02	2.14e-01	0.06760	-0.037200	5.65e-02	3.76e-01	1.78e-01
REACTOME DISSOLUTION OF FIBRIN CLOT	13	8.92e-01	9.30e-01	0.06740	-0.002290	-6.74e-02	9.89e-01	6.74e-01
REACTOME SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	612	4.13e-02	1.38e-01	0.06720	0.059600	3.10e-02	1.16e-02	1.90e-01
REACTOME SUMOYLATION OF RNA BINDING PROTEINS	45	5.50e-01	6.95e-01	0.06680	0.039800	-5.36e-02	6.44e-01	5.34e-01
REACTOME MITOTIC PROMETAPHASE	186	1.39e-01	3.07e-01	0.06670	0.065400	-1.31e-02	1.24e-01	7.58e-01
REACTOME TRP CHANNELS	27	6.98e-01	8.07e-01	0.06640	-0.043400	5.03e-02	6.96e-01	6.51e-01
REACTOME VESICLE MEDIATED TRANSPORT	639	2.51e-02	1.01e-01	0.06600	0.062000	2.26e-02	7.36e-03	3.28e-01
REACTOME PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS	8	9.66e-01	9.83e-01	0.06550	0.048200	4.43e-02	8.13e-01	8.28e-01
REACTOME TRIGLYCERIDE METABOLISM	35	6.74e-01	7.92e-01	0.06500	-0.060800	2.29e-02	5.34e-01	8.15e-01
REACTOME CELL CELL COMMUNICATION	117	5.46e-01	6.92e-01	0.06470	0.027000	5.88e-02	6.14e-01	2.72e-01
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	14	9.34e-01	9.61e-01	0.06450	-0.057200	-2.97e-02	7.11e-01	8.48e-01
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	147	3.21e-01	4.98e-01	0.06390	0.003360	6.39e-02	9.44e-01	1.81e-01
REACTOME RAP1 SIGNALLING	16	8.96e-01	9.32e-01	0.06300	0.062400	8.99e-03	6.66e-01	9.50e-01
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	14	8.50e-01	9.06e-01	0.06260	0.051000	-3.64e-02	7.41e-01	8.14e-01
REACTOME SIGNALING BY VEGF	102	5.16e-01	6.73e-01	0.06240	0.010500	6.15e-02	8.54e-01	2.83e-01
REACTOME RHO GTPASES ACTIVATE NADPH OXIDASES	21	8.86e-01	9.28e-01	0.06210	0.059900	1.63e-02	6.35e-01	8.97e-01
REACTOME SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION	8	9.62e-01	9.81e-01	0.06200	-0.056700	-2.51e-02	7.81e-01	9.02e-01
REACTOME INTERLEUKIN 20 FAMILY SIGNALING	24	8.99e-01	9.33e-01	0.06120	0.027800	5.45e-02	8.13e-01	6.44e-01
REACTOME ZINC TRANSPORTERS	15	8.71e-01	9.18e-01	0.06120	0.059500	-1.42e-02	6.90e-01	9.24e-01
REACTOME INTRAFLAGELLAR TRANSPORT	49	6.49e-01	7.74e-01	0.06100	0.059900	-1.13e-02	4.68e-01	8.91e-01
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	17	9.33e-01	9.61e-01	0.06000	0.029800	5.20e-02	8.32e-01	7.10e-01
REACTOME TYSND1 CLEAVES PEROXISOMAL PROTEINS	7	9.76e-01	9.88e-01	0.05930	0.042400	4.14e-02	8.46e-01	8.49e-01
REACTOME RHOG GTPASE CYCLE	69	7.87e-01	8.67e-01	0.05870	0.037900	4.48e-02	5.86e-01	5.20e-01
REACTOME TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	82	4.54e-01	6.18e-01	0.05860	-0.052600	2.58e-02	4.10e-01	6.87e-01
REACTOME MISCELLANEOUS TRANSPORT AND BINDING EVENTS	23	8.58e-01	9.12e-01	0.05780	0.000401	5.78e-02	9.97e-01	6.32e-01
REACTOME SODIUM CALCIUM EXCHANGERS	11	8.99e-01	9.33e-01	0.05760	-0.049000	3.02e-02	7.78e-01	8.62e-01
REACTOME RHO GTPASE CYCLE	414	2.60e-01	4.54e-01	0.05680	0.034900	4.48e-02	2.23e-01	1.18e-01
REACTOME CARDIAC CONDUCTION	125	4.00e-01	5.76e-01	0.05660	-0.008130	5.61e-02	8.75e-01	2.79e-01
REACTOME METABOLISM OF CARBOHYDRATES	276	2.71e-01	4.64e-01	0.05590	0.054200	1.36e-02	1.21e-01	6.97e-01
REACTOME DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	75	6.46e-01	7.72e-01	0.05480	-0.001840	-5.48e-02	9.78e-01	4.12e-01
REACTOME SUMOYLATION OF IMMUNE RESPONSE PROTEINS	10	9.19e-01	9.50e-01	0.05370	0.045700	-2.82e-02	8.02e-01	8.77e-01
REACTOME PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	26	8.06e-01	8.80e-01	0.05340	0.027400	-4.58e-02	8.09e-01	6.86e-01
REACTOME CHL1 INTERACTIONS	9	9.30e-01	9.59e-01	0.05340	0.024200	-4.76e-02	9.00e-01	8.05e-01
REACTOME ORGANELLE BIOGENESIS AND MAINTENANCE	256	2.17e-01	4.07e-01	0.05320	0.053100	-3.06e-03	1.43e-01	9.33e-01
REACTOME RECYCLING PATHWAY OF L1	43	8.70e-01	9.18e-01	0.05310	0.046500	2.55e-02	5.98e-01	7.72e-01
REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	21	8.65e-01	9.16e-01	0.05250	-0.050800	1.31e-02	6.87e-01	9.17e-01
REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	14	9.63e-01	9.81e-01	0.05210	0.036000	3.77e-02	8.16e-01	8.07e-01
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	89	7.40e-01	8.33e-01	0.05160	-0.020600	-4.74e-02	7.37e-01	4.40e-01
REACTOME BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	10	9.26e-01	9.55e-01	0.05090	0.030300	-4.09e-02	8.68e-01	8.23e-01
REACTOME METABOLISM OF VITAMINS AND COFACTORS	181	3.63e-01	5.43e-01	0.05050	0.050200	-5.04e-03	2.43e-01	9.07e-01
REACTOME MUSCLE CONTRACTION	194	3.29e-01	5.08e-01	0.05050	-0.050000	6.43e-03	2.29e-01	8.77e-01
REACTOME DEVELOPMENTAL BIOLOGY	1056	1.35e-03	1.03e-02	0.04980	0.047000	-1.62e-02	9.53e-03	3.71e-01
REACTOME GAP JUNCTION DEGRADATION	12	9.16e-01	9.49e-01	0.04940	0.030300	-3.90e-02	8.56e-01	8.15e-01
REACTOME FATTY ACID METABOLISM	168	3.02e-01	4.90e-01	0.04880	0.031200	-3.75e-02	4.84e-01	4.01e-01
REACTOME HCMV EARLY EVENTS	70	6.14e-01	7.47e-01	0.04830	0.029700	-3.80e-02	6.67e-01	5.82e-01
REACTOME SIGNALING BY BRAF AND RAF1 FUSIONS	62	8.23e-01	8.89e-01	0.04810	-0.045200	-1.63e-02	5.38e-01	8.24e-01
REACTOME GOLGI TO ER RETROGRADE TRANSPORT	132	6.37e-01	7.64e-01	0.04710	0.045800	1.12e-02	3.64e-01	8.24e-01
REACTOME COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	98	6.64e-01	7.83e-01	0.04610	0.046100	8.22e-04	4.30e-01	9.89e-01
REACTOME RHOA GTPASE CYCLE	138	4.18e-01	5.90e-01	0.04610	-0.028300	3.64e-02	5.66e-01	4.60e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE	5	9.88e-01	9.93e-01	0.04590	0.024200	3.90e-02	9.25e-01	8.80e-01
REACTOME SUMOYLATION OF DNA REPLICATION PROTEINS	44	8.14e-01	8.86e-01	0.04570	0.005290	-4.53e-02	9.52e-01	6.03e-01
REACTOME PYROPTOSIS	26	8.51e-01	9.07e-01	0.04540	0.029500	-3.46e-02	7.95e-01	7.60e-01
REACTOME ABACAVIR ADME	9	9.68e-01	9.83e-01	0.04540	-0.045000	-5.83e-03	8.15e-01	9.76e-01
REACTOME OTHER SEMAPHORIN INTERACTIONS	18	8.96e-01	9.32e-01	0.04500	-0.033400	3.01e-02	8.06e-01	8.25e-01
REACTOME SIGNAL TRANSDUCTION BY L1	20	9.14e-01	9.47e-01	0.04480	-0.005380	4.45e-02	9.67e-01	7.31e-01
REACTOME DEATH RECEPTOR SIGNALING	142	5.04e-01	6.60e-01	0.04450	0.009990	-4.34e-02	8.37e-01	3.72e-01
REACTOME PTK6 PROMOTES HIF1A STABILIZATION	6	9.71e-01	9.85e-01	0.04360	0.013100	-4.16e-02	9.56e-01	8.60e-01
REACTOME ATTACHMENT AND ENTRY	16	9.43e-01	9.68e-01	0.04260	-0.042600	1.48e-05	7.68e-01	1.00e+00
REACTOME NEUROFASCIN INTERACTIONS	6	9.71e-01	9.85e-01	0.04200	0.038600	-1.64e-02	8.70e-01	9.44e-01
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	183	3.87e-01	5.66e-01	0.04180	0.025900	-3.28e-02	5.46e-01	4.44e-01
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	31	9.47e-01	9.70e-01	0.04150	0.032000	2.65e-02	7.58e-01	7.99e-01
REACTOME MHC CLASS II ANTIGEN PRESENTATION	121	5.49e-01	6.95e-01	0.04130	0.021900	-3.50e-02	6.78e-01	5.06e-01
REACTOME ALK MUTANTS BIND TKIS	12	9.41e-01	9.67e-01	0.04120	0.031900	-2.61e-02	8.48e-01	8.76e-01
REACTOME PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	73	6.95e-01	8.05e-01	0.04070	-0.026500	3.09e-02	6.95e-01	6.48e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	13	9.79e-01	9.90e-01	0.04030	-0.028300	-2.88e-02	8.60e-01	8.57e-01
REACTOME RHOD GTPASE CYCLE	48	9.23e-01	9.53e-01	0.03990	0.023600	3.22e-02	7.77e-01	7.00e-01
REACTOME CELL JUNCTION ORGANIZATION	82	7.70e-01	8.56e-01	0.03960	-0.000603	3.96e-02	9.92e-01	5.35e-01
REACTOME REPRODUCTION	81	8.71e-01	9.18e-01	0.03940	-0.033400	-2.09e-02	6.03e-01	7.46e-01
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	247	4.85e-01	6.44e-01	0.03770	0.037700	-1.26e-03	3.07e-01	9.73e-01
REACTOME HEMOSTASIS	571	4.59e-01	6.22e-01	0.03730	0.024800	2.79e-02	3.11e-01	2.54e-01
REACTOME IRE1ALPHA ACTIVATES CHAPERONES	47	8.31e-01	8.95e-01	0.03620	0.024600	-2.65e-02	7.70e-01	7.53e-01
REACTOME PHASE 1 INACTIVATION OF FAST NA CHANNELS	6	9.89e-01	9.93e-01	0.03540	-0.010500	-3.38e-02	9.64e-01	8.86e-01
REACTOME SARS COV 2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS	12	9.66e-01	9.83e-01	0.03530	-0.004900	3.49e-02	9.77e-01	8.34e-01
REACTOME SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	15	9.49e-01	9.70e-01	0.03420	0.025100	-2.32e-02	8.66e-01	8.77e-01
REACTOME SIGNALING BY HIPPO	19	9.40e-01	9.66e-01	0.03410	0.015300	-3.04e-02	9.08e-01	8.18e-01
REACTOME INOSITOL PHOSPHATE METABOLISM	44	8.63e-01	9.14e-01	0.03330	-0.024300	2.27e-02	7.80e-01	7.94e-01
REACTOME PLATELET AGGREGATION PLUG FORMATION	39	8.79e-01	9.26e-01	0.03310	-0.025200	2.15e-02	7.85e-01	8.16e-01
REACTOME DISEASES OF METABOLISM	232	6.00e-01	7.35e-01	0.03250	0.032400	-1.59e-03	3.95e-01	9.67e-01
REACTOME ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	92	8.67e-01	9.17e-01	0.03210	0.031100	8.17e-03	6.07e-01	8.92e-01
REACTOME TRANSPORT OF SMALL MOLECULES	690	3.23e-01	5.00e-01	0.03110	-0.030800	-4.15e-03	1.67e-01	8.52e-01
REACTOME NICOTINAMIDE SALVAGING	17	9.84e-01	9.91e-01	0.03110	0.022000	2.19e-02	8.75e-01	8.76e-01
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	89	9.16e-01	9.49e-01	0.03090	-0.024700	-1.85e-02	6.86e-01	7.62e-01
REACTOME CHYLOMICRON CLEARANCE	5	9.89e-01	9.93e-01	0.03060	-0.004270	3.03e-02	9.87e-01	9.07e-01
REACTOME REGULATION OF LIPID METABOLISM BY PPARALPHA	114	7.73e-01	8.58e-01	0.03050	0.029800	-6.52e-03	5.82e-01	9.04e-01
REACTOME SIGNALING BY MET	78	8.22e-01	8.89e-01	0.03020	0.027600	-1.22e-02	6.73e-01	8.52e-01
REACTOME TRANSPORT AND SYNTHESIS OF PAPS	6	9.94e-01	9.96e-01	0.03000	0.026600	1.37e-02	9.10e-01	9.54e-01
REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	14	9.68e-01	9.83e-01	0.02970	0.028100	-9.48e-03	8.55e-01	9.51e-01
REACTOME TRIGLYCERIDE CATABOLISM	23	9.51e-01	9.73e-01	0.02930	-0.007910	2.82e-02	9.48e-01	8.15e-01
REACTOME DEPOLYMERISATION OF THE NUCLEAR LAMINA	14	9.88e-01	9.93e-01	0.02860	-0.018100	-2.22e-02	9.06e-01	8.86e-01
REACTOME PEPTIDE HORMONE METABOLISM	83	8.63e-01	9.14e-01	0.02830	-0.003170	2.81e-02	9.60e-01	6.58e-01
REACTOME IKBA VARIANT LEADS TO EDA ID	6	9.89e-01	9.93e-01	0.02800	-0.005270	2.75e-02	9.82e-01	9.07e-01
REACTOME SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	9.19e-01	9.50e-01	0.02750	0.021300	-1.74e-02	8.23e-01	8.54e-01
REACTOME CILIUM ASSEMBLY	188	7.94e-01	8.72e-01	0.02490	0.024900	3.44e-04	5.55e-01	9.94e-01
REACTOME PTK6 EXPRESSION	5	9.97e-01	9.98e-01	0.02430	-0.019200	-1.48e-02	9.41e-01	9.54e-01
REACTOME AFLATOXIN ACTIVATION AND DETOXIFICATION	19	9.89e-01	9.93e-01	0.02420	-0.016000	-1.81e-02	9.04e-01	8.91e-01
REACTOME SIGNALING BY BMP	27	9.57e-01	9.77e-01	0.02330	-0.017000	1.60e-02	8.79e-01	8.86e-01
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION OF SATURATED FATTY ACIDS	11	9.84e-01	9.91e-01	0.02310	0.010100	-2.08e-02	9.54e-01	9.05e-01
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	69	9.63e-01	9.81e-01	0.02270	-0.012500	-1.89e-02	8.57e-01	7.86e-01
REACTOME CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	45	9.47e-01	9.70e-01	0.02260	0.022300	-3.87e-03	7.96e-01	9.64e-01
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	9.81e-01	9.90e-01	0.02120	0.015800	-1.42e-02	9.19e-01	9.27e-01
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	20	9.75e-01	9.88e-01	0.02120	-0.018600	1.00e-02	8.85e-01	9.38e-01
REACTOME KINESINS	59	9.77e-01	9.89e-01	0.01940	-0.016000	-1.09e-02	8.32e-01	8.85e-01
REACTOME FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	28	9.81e-01	9.90e-01	0.01780	0.001240	-1.78e-02	9.91e-01	8.71e-01
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	128	9.80e-01	9.90e-01	0.01240	0.007680	9.80e-03	8.81e-01	8.48e-01
REACTOME DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	17	9.95e-01	9.97e-01	0.01010	-0.008980	4.62e-03	9.49e-01	9.74e-01
REACTOME METABOLISM OF LIPIDS	688	8.86e-01	9.28e-01	0.00960	-0.009600	-2.15e-04	6.67e-01	9.92e-01
REACTOME ONCOGENIC MAPK SIGNALING	77	9.84e-01	9.91e-01	0.00844	-0.005610	6.31e-03	9.32e-01	9.24e-01
REACTOME DISEASES OF GLYCOSYLATION	135	9.81e-01	9.90e-01	0.00683	0.005140	-4.50e-03	9.18e-01	9.28e-01
REACTOME SLC TRANSPORTER DISORDERS	92	9.93e-01	9.96e-01	0.00672	0.000967	6.65e-03	9.87e-01	9.12e-01
REACTOME GP1B IX V ACTIVATION SIGNALLING	11	9.99e-01	1.00e+00	0.00595	-0.000979	-5.87e-03	9.96e-01	9.73e-01
REACTOME GENE SILENCING BY RNA	78	1.00e+00	1.00e+00	0.00146	-0.000679	-1.30e-03	9.92e-01	9.84e-01

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Detailed Gene set reports

REACTOME_FORMATION_OF_LATERAL_PLATE_MESODERM

REACTOME_FORMATION_OF_LATERAL_PLATE_MESODERM

metric	value
setSize	5
pMANOVA	0.000339
p.adjustMANOVA	0.0031
s.dist	1.26
s.Discovery	0.925
s.Replication	0.861
p.Discovery	0.000339
p.Replication	0.000851

Top 20 genes

Gene	Discovery	Replication
BMP4	10898	10280
GATA4	10501	9651
SHH	10259	8808
IHH	9451	8091
FOXF1	9966	7081

Click HERE to show all gene set members

All member genes

	Discovery	Replication
BMP4	10898	10280
FOXF1	9966	7081
GATA4	10501	9651
IHH	9451	8091
SHH	10259	8808

---

---

REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_EARLY_PANCREATIC_PRECURSOR_CELLS

REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_EARLY_PANCREATIC_PRECURSOR_CELLS

metric	value
setSize	8
pMANOVA	2.86e-06
p.adjustMANOVA	3.81e-05
s.dist	1.26
s.Discovery	0.931
s.Replication	0.852
p.Discovery	5.09e-06
p.Replication	2.97e-05

Top 20 genes

Gene	Discovery	Replication
PTF1A	11139	10499
NKX6-1	11065	10465
PDX1	10895	9985
ONECUT1	10697	9730
FGF10	10355	9872
NR5A2	9467	8660
ONECUT3	10150	6076
HNF1B	8528	4057

Click HERE to show all gene set members

All member genes

	Discovery	Replication
FGF10	10355	9872
HNF1B	8528	4057
NKX6-1	11065	10465
NR5A2	9467	8660
ONECUT1	10697	9730
ONECUT3	10150	6076
PDX1	10895	9985
PTF1A	11139	10499

---

---

REACTOME_DOPAMINE_RECEPTORS

REACTOME_DOPAMINE_RECEPTORS

metric	value
setSize	5
pMANOVA	0.000436
p.adjustMANOVA	0.00383
s.dist	1.25
s.Discovery	0.895
s.Replication	0.866
p.Discovery	0.000526
p.Replication	0.000799

Top 20 genes

Gene	Discovery	Replication
DRD5	11158	10535
DRD4	10332	9413
DRD1	10108	8868
DRD3	9210	9266
DRD2	8361	6116

Click HERE to show all gene set members

All member genes

	Discovery	Replication
DRD1	10108	8868
DRD2	8361	6116
DRD3	9210	9266
DRD4	10332	9413
DRD5	11158	10535

---

---

REACTOME_ADRENOCEPTORS

REACTOME_ADRENOCEPTORS

metric	value
setSize	9
pMANOVA	1.97e-05
p.adjustMANOVA	0.000224
s.dist	1.08
s.Discovery	0.86
s.Replication	0.651
p.Discovery	7.91e-06
p.Replication	0.000722

Top 20 genes

Gene	Discovery	Replication
ADRB1	10661	9990
ADRA1D	10046	9658
ADRA2C	10421	8774
ADRB3	10272	8669
ADRA2B	9741	8458
ADRA1A	9447	8086
ADRA2A	9472	6962
ADRA1B	8137	4522

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ADRA1A	9447.0	8086
ADRA1B	8137.0	4522
ADRA1D	10046.0	9658
ADRA2A	9472.0	6962
ADRA2B	9741.0	8458
ADRA2C	10421.0	8774
ADRB1	10661.0	9990
ADRB2	6252.5	-10127
ADRB3	10272.0	8669

---

---

REACTOME_VITAMINS

REACTOME_VITAMINS

metric	value
setSize	6
pMANOVA	0.000697
p.adjustMANOVA	0.00573
s.dist	1.08
s.Discovery	0.869
s.Replication	0.635
p.Discovery	0.000226
p.Replication	0.00704

Top 20 genes

Gene	Discovery	Replication
CYP26C1	10683	10042.0
CYP27B1	9920	9257.0
CYP26B1	9770	9137.0
CYP26A1	10436	8015.5
CYP24A1	9226	8874.0

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CYP24A1	9226	8874.0
CYP26A1	10436	8015.5
CYP26B1	9770	9137.0
CYP26C1	10683	10042.0
CYP27B1	9920	9257.0
CYP2R1	6986	-9835.0

---

---

REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS

REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS

metric	value
setSize	14
pMANOVA	1.2e-07
p.adjustMANOVA	2.18e-06
s.dist	1.06
s.Discovery	-0.817
s.Replication	-0.672
p.Discovery	1.18e-07
p.Replication	1.33e-05

Top 20 genes

Gene	Discovery	Replication
C1R	-13831.0	-14539
MBL2	-13738.0	-14431
C1S	-13622.0	-14400
C1QC	-12964.0	-14353
CRP	-12797.0	-13498
FCN2	-12927.0	-12382
FCN3	-11892.5	-13408
MASP1	-11726.0	-13566
C1QB	-12548.0	-11333
C1QA	-10377.0	-12606
FCN1	-13107.0	-7512
COLEC10	-10819.0	-8206
MASP2	-9110.0	-440

Click HERE to show all gene set members

All member genes

	Discovery	Replication
C1QA	-10377.0	-12606
C1QB	-12548.0	-11333
C1QC	-12964.0	-14353
C1R	-13831.0	-14539
C1S	-13622.0	-14400
COLEC10	-10819.0	-8206
COLEC11	-6915.0	1389
CRP	-12797.0	-13498
FCN1	-13107.0	-7512
FCN2	-12927.0	-12382
FCN3	-11892.5	-13408
MASP1	-11726.0	-13566
MASP2	-9110.0	-440
MBL2	-13738.0	-14431

---

---

REACTOME_FICOLINS_BIND_TO_REPETITIVE_CARBOHYDRATE_STRUCTURES_ON_THE_TARGET_CELL_SURFACE

REACTOME_FICOLINS_BIND_TO_REPETITIVE_CARBOHYDRATE_STRUCTURES_ON_THE_TARGET_CELL_SURFACE

metric	value
setSize	5
pMANOVA	0.00566
p.adjustMANOVA	0.0336
s.dist	0.992
s.Discovery	-0.807
s.Replication	-0.577
p.Discovery	0.00178
p.Replication	0.0254

Top 20 genes

Gene	Discovery	Replication
FCN2	-12927.0	-12382
FCN3	-11892.5	-13408
MASP1	-11726.0	-13566
FCN1	-13107.0	-7512
MASP2	-9110.0	-440

Click HERE to show all gene set members

All member genes

	Discovery	Replication
FCN1	-13107.0	-7512
FCN2	-12927.0	-12382
FCN3	-11892.5	-13408
MASP1	-11726.0	-13566
MASP2	-9110.0	-440

---

---

REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_ENDOCRINE_COMMITTED_NEUROG3_PROGENITOR_CELLS

REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_ENDOCRINE_COMMITTED_NEUROG3_PROGENITOR_CELLS

metric	value
setSize	5
pMANOVA	0.00875
p.adjustMANOVA	0.0465
s.dist	0.974
s.Discovery	0.713
s.Replication	0.663
p.Discovery	0.00576
p.Replication	0.0102

Top 20 genes

Gene	Discovery	Replication
NEUROD1	10981	10326
NKX2-2	11008	10178
INSM1	10727	9075
NEUROG3	10541	8915

Click HERE to show all gene set members

All member genes

	Discovery	Replication
INSM1	10727	9075
NEUROD1	10981	10326
NEUROG3	10541	8915
NKX2-2	11008	10178
PAX4	-5646	-7162

---

---

REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION

REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION

metric	value
setSize	8
pMANOVA	0.000653
p.adjustMANOVA	0.00551
s.dist	0.921
s.Discovery	-0.77
s.Replication	-0.507
p.Discovery	0.000163
p.Replication	0.013

Top 20 genes

Gene	Discovery	Replication
MBL2	-13738.0	-14431
FCN2	-12927.0	-12382
FCN3	-11892.5	-13408
MASP1	-11726.0	-13566
FCN1	-13107.0	-7512
COLEC10	-10819.0	-8206
MASP2	-9110.0	-440

Click HERE to show all gene set members

All member genes

	Discovery	Replication
COLEC10	-10819.0	-8206
COLEC11	-6915.0	1389
FCN1	-13107.0	-7512
FCN2	-12927.0	-12382
FCN3	-11892.5	-13408
MASP1	-11726.0	-13566
MASP2	-9110.0	-440
MBL2	-13738.0	-14431

---

---

REACTOME_ORGANIC_ANION_TRANSPORT

REACTOME_ORGANIC_ANION_TRANSPORT

metric	value
setSize	5
pMANOVA	0.00927
p.adjustMANOVA	0.0486
s.dist	0.897
s.Discovery	-0.789
s.Replication	-0.427
p.Discovery	0.00224
p.Replication	0.0985

Top 20 genes

Gene	Discovery	Replication
SLC22A7	-13970	-14450
SLC22A8	-11145	-13227
SLC22A11	-11906	-7657
SLC22A6	-9734	-4306

Click HERE to show all gene set members

All member genes

	Discovery	Replication
SLC22A11	-11906	-7657
SLC22A12	-10902	1876
SLC22A6	-9734	-4306
SLC22A7	-13970	-14450
SLC22A8	-11145	-13227

---

---

REACTOME_FORMATION_OF_AXIAL_MESODERM

REACTOME_FORMATION_OF_AXIAL_MESODERM

metric	value
setSize	13
pMANOVA	4.03e-05
p.adjustMANOVA	0.000428
s.dist	0.883
s.Discovery	0.614
s.Replication	0.635
p.Discovery	0.000126
p.Replication	7.31e-05

Top 20 genes

Gene	Discovery	Replication
FOXA2	11004	10349
FOXA1	11028	10249
NOTO	10769	9694
SHH	10259	8808
TCF7	9607	8840
LEF1	9536	8793
FOXH1	9400	7937
SMAD2	8647	8398
TEAD2	9404	6176
SMAD3	2826	3512

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CTNNB1	-5776	3825
FOXA1	11028	10249
FOXA2	11004	10349
FOXH1	9400	7937
LEF1	9536	8793
NOTO	10769	9694
SHH	10259	8808
SMAD2	8647	8398
SMAD3	2826	3512
TCF7	9607	8840
TEAD2	9404	6176
TEAD4	-6535	-4845
YAP1	1258	-4894

---

---

REACTOME_CONJUGATION_OF_BENZOATE_WITH_GLYCINE

REACTOME_CONJUGATION_OF_BENZOATE_WITH_GLYCINE

metric	value
setSize	6
pMANOVA	0.00965
p.adjustMANOVA	0.0501
s.dist	0.872
s.Discovery	-0.675
s.Replication	-0.552
p.Discovery	0.00418
p.Replication	0.0193

Top 20 genes

Gene	Discovery	Replication
ACSM2B	-11990	-14245.0
GLYAT	-9258	-10886.5
GLYATL3	-13682	-7260.0
ACSM1	-6680	-9759.0
GLYATL1	-7394	-7922.0
GLYATL2	-11492	-4762.0

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ACSM1	-6680	-9759.0
ACSM2B	-11990	-14245.0
GLYAT	-9258	-10886.5
GLYATL1	-7394	-7922.0
GLYATL2	-11492	-4762.0
GLYATL3	-13682	-7260.0

---

---

REACTOME_DIGESTION_OF_DIETARY_LIPID

REACTOME_DIGESTION_OF_DIETARY_LIPID

metric	value
setSize	7
pMANOVA	0.00616
p.adjustMANOVA	0.0361
s.dist	0.827
s.Discovery	-0.681
s.Replication	-0.47
p.Discovery	0.00181
p.Replication	0.0314

Top 20 genes

Gene	Discovery	Replication
PNLIPRP3	-13468	-10319.0
PNLIP	-11792	-11703.0
PNLIPRP1	-10519	-10269.0
CLPS	-9022	-10143.0
CEL	-11755	-6461.0
LIPF	-11434	-4458.5
PNLIPRP2	-3079	-3338.0

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CEL	-11755	-6461.0
CLPS	-9022	-10143.0
LIPF	-11434	-4458.5
PNLIP	-11792	-11703.0
PNLIPRP1	-10519	-10269.0
PNLIPRP2	-3079	-3338.0
PNLIPRP3	-13468	-10319.0

---

---

REACTOME_DIGESTION

REACTOME_DIGESTION

metric	value
setSize	17
pMANOVA	3.78e-06
p.adjustMANOVA	4.86e-05
s.dist	0.82
s.Discovery	-0.692
s.Replication	-0.441
p.Discovery	7.84e-07
p.Replication	0.00166

Top 20 genes

Gene	Discovery	Replication
GUCA2B	-14015.0	-14439.0
TREH	-13484.0	-13224.0
MGAM	-12932.0	-13497.0
CHIT1	-12348.0	-13256.5
PNLIPRP3	-13468.0	-10319.0
PNLIP	-11792.0	-11703.0
GUCY2C	-10382.0	-13136.0
GUCA2A	-13076.0	-9110.0
PNLIPRP1	-10519.0	-10269.0
ALPI	-11490.0	-9105.0
CLPS	-9022.0	-10143.0
CEL	-11755.0	-6461.0
LIPF	-11434.0	-4458.5
PNLIPRP2	-3079.0	-3338.0
CHIA	-9274.5	-1006.0

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ALPI	-11490.0	-9105.0
AMY2B	-10217.0	5885.0
CEL	-11755.0	-6461.0
CHIA	-9274.5	-1006.0
CHIT1	-12348.0	-13256.5
CLPS	-9022.0	-10143.0
GUCA2A	-13076.0	-9110.0
GUCA2B	-14015.0	-14439.0
GUCY2C	-10382.0	-13136.0
LCT	3370.0	6232.0
LIPF	-11434.0	-4458.5
MGAM	-12932.0	-13497.0
PNLIP	-11792.0	-11703.0
PNLIPRP1	-10519.0	-10269.0
PNLIPRP2	-3079.0	-3338.0
PNLIPRP3	-13468.0	-10319.0
TREH	-13484.0	-13224.0

---

---

REACTOME_HYALURONAN_BIOSYNTHESIS_AND_EXPORT

REACTOME_HYALURONAN_BIOSYNTHESIS_AND_EXPORT

metric	value
setSize	5
pMANOVA	0.0292
p.adjustMANOVA	0.111
s.dist	0.82
s.Discovery	0.478
s.Replication	0.666
p.Discovery	0.0642
p.Replication	0.00986

Top 20 genes

Gene	Discovery	Replication
HAS3	9971	9453
HAS1	8951	9039
ABCC5	2193	7243
HAS2	8352	1499

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ABCC5	2193	7243
CEMIP	-6760	4314
HAS1	8951	9039
HAS2	8352	1499
HAS3	9971	9453

---

---

REACTOME_MINERALOCORTICOID_BIOSYNTHESIS

REACTOME_MINERALOCORTICOID_BIOSYNTHESIS

metric	value
setSize	6
pMANOVA	0.0124
p.adjustMANOVA	0.0602
s.dist	0.819
s.Discovery	-0.69
s.Replication	-0.442
p.Discovery	0.00341
p.Replication	0.0611

Top 20 genes

Gene	Discovery	Replication
CYP11B2	-12578	-12286
HSD3B1	-11886	-12410
CYP21A2	-10118	-11396
HSD3B2	-9553	-8670
CGA	-13038	-5390

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CGA	-13038	-5390
CYP11B2	-12578	-12286
CYP21A2	-10118	-11396
HSD3B1	-11886	-12410
HSD3B2	-9553	-8670
LHB	-4472	3701

---

---

REACTOME_POU5F1_OCT4_SOX2_NANOG_REPRESS_GENES_RELATED_TO_DIFFERENTIATION

REACTOME_POU5F1_OCT4_SOX2_NANOG_REPRESS_GENES_RELATED_TO_DIFFERENTIATION

metric	value
setSize	10
pMANOVA	0.00128
p.adjustMANOVA	0.00991
s.dist	0.817
s.Discovery	0.573
s.Replication	0.583
p.Discovery	0.00172
p.Replication	0.0014

Top 20 genes

Gene	Discovery	Replication
DKK1	11021	10456
SOX2	10993	10255
HHEX	10889	10304
CDX2	10952	10225
GSC	10939	10177
GATA6	8551	8087
EOMES	9585	3307

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CDX2	10952	10225.0
DKK1	11021	10456.0
EOMES	9585	3307.0
GATA6	8551	8087.0
GSC	10939	10177.0
HHEX	10889	10304.0
NANOG	-11024	-13199.0
POU5F1	-8505	3304.5
SOX2	10993	10255.0
TSC22D1	3999	-372.0

---

---

REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS

REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS

metric	value
setSize	10
pMANOVA	0.00133
p.adjustMANOVA	0.0102
s.dist	0.815
s.Discovery	0.563
s.Replication	0.589
p.Discovery	0.00205
p.Replication	0.00126

Top 20 genes

Gene	Discovery	Replication
TFAP2A	10931	10230
TFAP2C	10836	10243
TFAP2B	10785	10090
TFAP2D	10061	9289
TFAP2E	9013	8789
KCTD1	6719	1416
KCTD15	2155	1226

Click HERE to show all gene set members

All member genes

	Discovery	Replication
KCTD1	6719	1416
KCTD15	2155	1226
SUMO1	2954	-769
TFAP2A	10931	10230
TFAP2B	10785	10090
TFAP2C	10836	10243
TFAP2D	10061	9289
TFAP2E	9013	8789
UBE2I	-2800	1508
WWOX	-4460	1241

---

---

REACTOME_FGFRL1_MODULATION_OF_FGFR1_SIGNALING

REACTOME_FGFRL1_MODULATION_OF_FGFR1_SIGNALING

metric	value
setSize	13
pMANOVA	0.000429
p.adjustMANOVA	0.0038
s.dist	0.773
s.Discovery	0.559
s.Replication	0.534
p.Discovery	0.000483
p.Replication	0.000855

Top 20 genes

Gene	Discovery	Replication
FGF10	10355	9872
FGF17	10256	9622
FGF3	10323	9438
FGF5	10241	9303
FGF8	10179	9056
FGF4	9519	7834
FGF2	5389	7325
SPRED2	3218	2685
FGF23	3662	1885

Click HERE to show all gene set members

All member genes

	Discovery	Replication
FGF10	10355	9872
FGF17	10256	9622
FGF18	-3307	-3058
FGF2	5389	7325
FGF22	-845	3962
FGF23	3662	1885
FGF3	10323	9438
FGF4	9519	7834
FGF5	10241	9303
FGF8	10179	9056
FGFRL1	858	-6033
SPRED1	2516	-1711
SPRED2	3218	2685

---

---

REACTOME_EPITHELIAL_MESENCHYMAL_TRANSITION_EMT_DURING_GASTRULATION

REACTOME_EPITHELIAL_MESENCHYMAL_TRANSITION_EMT_DURING_GASTRULATION

metric	value
setSize	6
pMANOVA	0.0263
p.adjustMANOVA	0.103
s.dist	0.765
s.Discovery	0.61
s.Replication	0.462
p.Discovery	0.00961
p.Replication	0.0502

Top 20 genes

Gene	Discovery	Replication
CLDN7	10204	8166
SNAI1	8150	7769
EOMES	9585	3307
CDH1	7076	3778
OCLN	5818	1535

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CDH1	7076	3778
CLDN7	10204	8166
EOMES	9585	3307
FGFR1	-3500	-2274
OCLN	5818	1535
SNAI1	8150	7769

---

---

REACTOME_LINOLEIC_ACID_LA_METABOLISM

REACTOME_LINOLEIC_ACID_LA_METABOLISM

metric	value
setSize	7
pMANOVA	0.0109
p.adjustMANOVA	0.055
s.dist	0.757
s.Discovery	0.653
s.Replication	0.382
p.Discovery	0.00277
p.Replication	0.0799

Top 20 genes

Gene	Discovery	Replication
ELOVL2	10615	10066
ACSL1	6566	7376
FADS2	7046	4890
ELOVL3	7565	3403
ELOVL5	5699	1210
FADS1	4364	893

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ACSL1	6566	7376
ELOVL1	5477	-8897
ELOVL2	10615	10066
ELOVL3	7565	3403
ELOVL5	5699	1210
FADS1	4364	893
FADS2	7046	4890

---

---

REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOLIPASE_C_GAMMA_PLCG

REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOLIPASE_C_GAMMA_PLCG

metric	value
setSize	7
pMANOVA	0.0208
p.adjustMANOVA	0.0886
s.dist	0.742
s.Discovery	0.493
s.Replication	0.555
p.Discovery	0.0238
p.Replication	0.011

Top 20 genes

Gene	Discovery	Replication
IRS2	10455	10238
EPO	9839	8123
EPOR	8843	5963
PLCG1	6392	6165
LYN	6145	2520

Click HERE to show all gene set members

All member genes

	Discovery	Replication
EPO	9839	8123
EPOR	8843	5963
IRS2	10455	10238
JAK2	-4443	4942
LYN	6145	2520
PLCG1	6392	6165
PLCG2	-4071	-3701

---

---

REACTOME_ACTIVATION_OF_TRKA_RECEPTORS

REACTOME_ACTIVATION_OF_TRKA_RECEPTORS

metric	value
setSize	6
pMANOVA	0.0349
p.adjustMANOVA	0.123
s.dist	0.733
s.Discovery	0.589
s.Replication	0.436
p.Discovery	0.0124
p.Replication	0.0644

Top 20 genes

Gene	Discovery	Replication
ADCYAP1	10762	9812
ADORA2A	7895	9610
NGF	9243	7176
NTRK2	8234	4139

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ADCYAP1	10762	9812
ADCYAP1R1	-2342	-5637
ADORA2A	7895	9610
NGF	9243	7176
NTRK1	1924	-4781
NTRK2	8234	4139

---

---

REACTOME_DEFECTIVE_CHST6_CAUSES_MCDC1

REACTOME_DEFECTIVE_CHST6_CAUSES_MCDC1

metric	value
setSize	8
pMANOVA	0.00497
p.adjustMANOVA	0.031
s.dist	0.724
s.Discovery	-0.663
s.Replication	-0.29
p.Discovery	0.00116
p.Replication	0.155

Top 20 genes

Gene	Discovery	Replication
LUM	-13221	-14200
KERA	-13284	-11971
FMOD	-11028	-11828
PRELP	-9718	-11847
ACAN	-1126	-3319

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ACAN	-1126	-3319
CHST6	-3496	221
FMOD	-11028	-11828
KERA	-13284	-11971
LUM	-13221	-14200
OGN	-13966	5722
OMD	-13582	653
PRELP	-9718	-11847

---

---

REACTOME_TRANSCRIPTIONAL_REGULATION_OF_TESTIS_DIFFERENTIATION

REACTOME_TRANSCRIPTIONAL_REGULATION_OF_TESTIS_DIFFERENTIATION

metric	value
setSize	12
pMANOVA	0.00185
p.adjustMANOVA	0.0136
s.dist	0.715
s.Discovery	0.442
s.Replication	0.562
p.Discovery	0.00801
p.Replication	0.000746

Top 20 genes

Gene	Discovery	Replication
SOX9	10878	10209
FOXL2	10828	10045
GATA4	10501	9651
DHH	10329	7926
DMRT1	9793	8352
WT1	9841	8096
AMH	8898	8737
NR5A1	1805	5411

Click HERE to show all gene set members

All member genes

	Discovery	Replication
AMH	8898	8737
DHH	10329	7926
DMRT1	9793	8352
FGF9	-603	-2676
FOXL2	10828	10045
GATA4	10501	9651
NR5A1	1805	5411
PTGDS	-11354	-6205
SOX9	10878	10209
WNT4	-6395	-1555
WT1	9841	8096
ZFPM2	-5504	1829

---

---

REACTOME_AMINO_ACID_CONJUGATION

REACTOME_AMINO_ACID_CONJUGATION

metric	value
setSize	9
pMANOVA	0.00999
p.adjustMANOVA	0.0513
s.dist	0.713
s.Discovery	-0.537
s.Replication	-0.469
p.Discovery	0.00524
p.Replication	0.0149

Top 20 genes

Gene	Discovery	Replication
ACSM4	-13053	-13648.0
ACSM2B	-11990	-14245.0
ACSM5	-8459	-11970.0
GLYAT	-9258	-10886.5
GLYATL3	-13682	-7260.0
ACSM1	-6680	-9759.0
GLYATL1	-7394	-7922.0
GLYATL2	-11492	-4762.0

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ACSM1	-6680.0	-9759.0
ACSM2A	6991.5	7676.0
ACSM2B	-11990.0	-14245.0
ACSM4	-13053.0	-13648.0
ACSM5	-8459.0	-11970.0
GLYAT	-9258.0	-10886.5
GLYATL1	-7394.0	-7922.0
GLYATL2	-11492.0	-4762.0
GLYATL3	-13682.0	-7260.0

---

---

REACTOME_DIGESTION_AND_ABSORPTION

REACTOME_DIGESTION_AND_ABSORPTION

metric	value
setSize	22
pMANOVA	2.5e-06
p.adjustMANOVA	3.37e-05
s.dist	0.711
s.Discovery	-0.625
s.Replication	-0.339
p.Discovery	3.89e-07
p.Replication	0.00584

Top 20 genes

Gene	Discovery	Replication
GUCA2B	-14015.0	-14439.0
TREH	-13484.0	-13224.0
MGAM	-12932.0	-13497.0
CHIT1	-12348.0	-13256.5
PNLIPRP3	-13468.0	-10319.0
PNLIP	-11792.0	-11703.0
GUCY2C	-10382.0	-13136.0
GUCA2A	-13076.0	-9110.0
NPC1L1	-12961.0	-8469.0
PNLIPRP1	-10519.0	-10269.0
ALPI	-11490.0	-9105.0
CLPS	-9022.0	-10143.0
CEL	-11755.0	-6461.0
SLC5A1	-6295.0	-10342.0
LIPF	-11434.0	-4458.5
SLC2A5	-7871.0	-6164.0
PNLIPRP2	-3079.0	-3338.0
CHIA	-9274.5	-1006.0

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ALPI	-11490.0	-9105.0
AMY2B	-10217.0	5885.0
CEL	-11755.0	-6461.0
CHIA	-9274.5	-1006.0
CHIT1	-12348.0	-13256.5
CLPS	-9022.0	-10143.0
GUCA2A	-13076.0	-9110.0
GUCA2B	-14015.0	-14439.0
GUCY2C	-10382.0	-13136.0
LCT	3370.0	6232.0
LIPF	-11434.0	-4458.5
MGAM	-12932.0	-13497.0
NPC1L1	-12961.0	-8469.0
PNLIP	-11792.0	-11703.0
PNLIPRP1	-10519.0	-10269.0
PNLIPRP2	-3079.0	-3338.0
PNLIPRP3	-13468.0	-10319.0
RSC1A1	-7228.0	6151.5
SLC2A2	1628.0	8387.0
SLC2A5	-7871.0	-6164.0
SLC5A1	-6295.0	-10342.0
TREH	-13484.0	-13224.0

---

---

REACTOME_MODULATION_BY_MTB_OF_HOST_IMMUNE_SYSTEM

REACTOME_MODULATION_BY_MTB_OF_HOST_IMMUNE_SYSTEM

metric	value
setSize	6
pMANOVA	0.000306
p.adjustMANOVA	0.00283
s.dist	0.71
s.Discovery	0.666
s.Replication	-0.247
p.Discovery	0.00472
p.Replication	0.294

Top 20 genes

Gene	Discovery	Replication
B2M	7863	-10440
UBC	7109	-7495
UBB	9009	-5690
UBA52	5676	-8477
RPS27A	2553	-8724

Click HERE to show all gene set members

All member genes

	Discovery	Replication
B2M	7863	-10440
RPS27A	2553	-8724
TLR2	9350	9153
UBA52	5676	-8477
UBB	9009	-5690
UBC	7109	-7495

---

---

REACTOME_SIGNALING_BY_LRP5_MUTANTS

REACTOME_SIGNALING_BY_LRP5_MUTANTS

metric	value
setSize	6
pMANOVA	0.0487
p.adjustMANOVA	0.152
s.dist	0.709
s.Discovery	0.526
s.Replication	0.475
p.Discovery	0.0255
p.Replication	0.044

Top 20 genes

Gene	Discovery	Replication
DKK1	11021	10456
DKK2	10526	10164
DKK4	9836	9717
KREMEN2	8760	1293

Click HERE to show all gene set members

All member genes

	Discovery	Replication
DKK1	11021	10456
DKK2	10526	10164
DKK4	9836	9717
KREMEN1	-824	-9423
KREMEN2	8760	1293
LRP5	-8375	1063

---

---

REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

metric	value
setSize	21
pMANOVA	1.02e-05
p.adjustMANOVA	0.000122
s.dist	0.705
s.Discovery	-0.599
s.Replication	-0.372
p.Discovery	2.02e-06
p.Replication	0.00314

Top 20 genes

Gene	Discovery	Replication
C1R	-13831.0	-14539
MBL2	-13738.0	-14431
C1S	-13622.0	-14400
C1QC	-12964.0	-14353
CRP	-12797.0	-13498
FCN2	-12927.0	-12382
FCN3	-11892.5	-13408
MASP1	-11726.0	-13566
C1QB	-12548.0	-11333
C1QA	-10377.0	-12606
FCN1	-13107.0	-7512
C2	-9537.0	-9609
COLEC10	-10819.0	-8206
GZMM	-7819.0	-4089
CFB	-7114.0	-2074
MASP2	-9110.0	-440

Click HERE to show all gene set members

All member genes

	Discovery	Replication
C1QA	-10377.0	-12606
C1QB	-12548.0	-11333
C1QC	-12964.0	-14353
C1R	-13831.0	-14539
C1S	-13622.0	-14400
C2	-9537.0	-9609
C3	-4275.0	3830
C4A	-2787.5	4711
C4B	-2787.5	4711
CFB	-7114.0	-2074
CFD	9393.0	7746
COLEC10	-10819.0	-8206
COLEC11	-6915.0	1389
CRP	-12797.0	-13498
FCN1	-13107.0	-7512
FCN2	-12927.0	-12382
FCN3	-11892.5	-13408
GZMM	-7819.0	-4089
MASP1	-11726.0	-13566
MASP2	-9110.0	-440
MBL2	-13738.0	-14431

---

---

REACTOME_SYNTHESIS_OF_LIPOXINS_LX

REACTOME_SYNTHESIS_OF_LIPOXINS_LX

metric	value
setSize	6
pMANOVA	0.043
p.adjustMANOVA	0.142
s.dist	0.699
s.Discovery	0.581
s.Replication	0.389
p.Discovery	0.0137
p.Replication	0.0991

Top 20 genes

Gene	Discovery	Replication
HPGD	9245	8639
ALOX12	5804	7658
PTGR1	6092	4193
ALOX5AP	3274	2210

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ALOX12	5804	7658
ALOX5	2005	-4110
ALOX5AP	3274	2210
HPGD	9245	8639
LTC4S	8660	-1858
PTGR1	6092	4193

---

---

REACTOME_CD22_MEDIATED_BCR_REGULATION

REACTOME_CD22_MEDIATED_BCR_REGULATION

metric	value
setSize	5
pMANOVA	0.0845
p.adjustMANOVA	0.225
s.dist	0.695
s.Discovery	0.545
s.Replication	0.431
p.Discovery	0.0349
p.Replication	0.095

Top 20 genes

Gene	Discovery	Replication
CD22	10534	9833
CD79B	9545	9771
CD79A	9882	8687
LYN	6145	2520

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CD22	10534	9833
CD79A	9882	8687
CD79B	9545	9771
LYN	6145	2520
PTPN6	-9167	-14181

---

---

REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS

REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS

metric	value
setSize	11
pMANOVA	0.00544
p.adjustMANOVA	0.0328
s.dist	0.685
s.Discovery	0.521
s.Replication	0.445
p.Discovery	0.00276
p.Replication	0.0106

Top 20 genes

Gene	Discovery	Replication
TFAP2A	10931	10230
TFAP2C	10836	10243
TFAP2B	10785	10090
TFAP2D	10061	9289
TFAP2E	9013	8789
CITED4	9001	2845
CREBBP	2515	7619

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CITED2	6227	-8908
CITED4	9001	2845
CREBBP	2515	7619
EP300	-1546	845
TFAP2A	10931	10230
TFAP2B	10785	10090
TFAP2C	10836	10243
TFAP2D	10061	9289
TFAP2E	9013	8789
WWOX	-4460	1241
YEATS4	-7385	-13814

---

---

REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION

REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION

metric	value
setSize	9
pMANOVA	0.00279
p.adjustMANOVA	0.0194
s.dist	0.681
s.Discovery	0.213
s.Replication	0.647
p.Discovery	0.269
p.Replication	0.000774

Top 20 genes

Gene	Discovery	Replication
AGO1	10642	10187
NPAS4	10023	9244
TNRC6B	8375	5952
MOV10	2808	2706

Click HERE to show all gene set members

All member genes

	Discovery	Replication
AGO1	10642	10187
AGO2	-851	9068
AGO3	-3628	1780
AGO4	-8729	5984
MOV10	2808	2706
NPAS4	10023	9244
TNRC6A	-2870	3915
TNRC6B	8375	5952
TNRC6C	-5148	5737

---

---

REACTOME_VASOPRESSIN_LIKE_RECEPTORS

REACTOME_VASOPRESSIN_LIKE_RECEPTORS

metric	value
setSize	5
pMANOVA	0.0826
p.adjustMANOVA	0.221
s.dist	0.677
s.Discovery	0.569
s.Replication	0.367
p.Discovery	0.0275
p.Replication	0.156

Top 20 genes

Gene	Discovery	Replication
AVPR1A	11143	10527
AVP	9691	9401
OXTR	9616	8238

Click HERE to show all gene set members

All member genes

	Discovery	Replication
AVP	9691	9401
AVPR1A	11143	10527
AVPR1B	8796	-3126
OXT	-10747	-12507
OXTR	9616	8238

---

---

REACTOME_LIGAND_RECEPTOR_INTERACTIONS

REACTOME_LIGAND_RECEPTOR_INTERACTIONS

metric	value
setSize	8
pMANOVA	0.0232
p.adjustMANOVA	0.0955
s.dist	0.676
s.Discovery	0.535
s.Replication	0.414
p.Discovery	0.00883
p.Replication	0.0428

Top 20 genes

Gene	Discovery	Replication
SHH	10259	8808
DHH	10329	7926
HHIP	9356	8548
IHH	9451	8091
GAS1	9716	5456
PTCH1	5605	5390

Click HERE to show all gene set members

All member genes

	Discovery	Replication
BOC	-7692	-9589
CDON	-4952	-9811
DHH	10329	7926
GAS1	9716	5456
HHIP	9356	8548
IHH	9451	8091
PTCH1	5605	5390
SHH	10259	8808

---

---

REACTOME_OLFACTORY_SIGNALING_PATHWAY

REACTOME_OLFACTORY_SIGNALING_PATHWAY

metric	value
setSize	347
pMANOVA	1.23e-80
p.adjustMANOVA	2.01e-77
s.dist	0.674
s.Discovery	-0.596
s.Replication	-0.315
p.Discovery	5.89e-82
p.Replication	5.07e-24

Top 20 genes

Gene	Discovery	Replication
OR5B17	-14199.0	-14820.0
OR2L5	-14179.5	-14583.0
OR2S2	-14138.0	-14586.5
OR2B6	-14164.0	-14554.0
OR5M10	-14063.0	-14624.0
OR10S1	-13665.0	-14715.0
OR5T3	-14072.0	-14217.5
OR5T1	-13956.5	-14262.0
OR10J3	-14041.0	-14089.0
OR5T2	-14102.0	-13808.5
OR8G5	-13631.0	-14124.0
OR13A1	-13782.0	-13965.0
OR8G1	-14048.0	-13553.0
OR2H2	-12949.0	-14463.5
OR51G2	-12972.0	-14369.0
OR5AN1	-13643.0	-13633.0
OR6Y1	-13593.0	-13560.0
OR51F2	-12849.0	-14342.0
OR9A4	-13216.0	-13897.0
OR2V1	-13412.0	-13652.0

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ADCY3	-13.0	7231.0
ANO2	-10015.0	-12399.0
CNGA4	-10924.0	-3348.0
CNGB1	-10969.0	-8429.0
EBF1	-1243.0	-4131.0
GNAL	5493.0	4023.0
GNB1	3803.0	6846.0
GNG13	8788.0	4605.0
LDB1	7808.0	-4325.0
LHX2	10722.0	9907.0
OR10A2	-12841.0	-3679.0
OR10A3	-10028.0	-7016.0
OR10A4	-5986.0	-4130.0
OR10A5	-12891.0	-3770.0
OR10A6	-12725.0	-3365.0
OR10A7	-13447.0	-7950.0
OR10AD1	-4672.0	2903.0
OR10AG1	-10843.0	-13045.0
OR10C1	-13154.0	-11067.0
OR10G2	-12326.5	-13348.0
OR10G3	-10767.0	-8796.0
OR10G4	-12491.5	-14165.0
OR10G7	-10691.5	-10019.0
OR10G8	-11353.0	-10031.0
OR10G9	-12550.0	-13945.0
OR10H1	-4581.0	-1085.0
OR10H2	-657.0	-6406.5
OR10H3	-9937.0	4393.0
OR10H4	-9371.0	2825.0
OR10H5	-10146.0	-13123.0
OR10J1	-12047.0	-14488.0
OR10J3	-14041.0	-14089.0
OR10J5	-5774.0	-12049.0
OR10K1	-14136.5	-3260.0
OR10K2	-12689.0	-13256.5
OR10P1	-11546.0	-12788.0
OR10Q1	-7089.0	5612.0
OR10S1	-13665.0	-14715.0
OR10T2	8679.0	-2212.0
OR10V1	-12109.0	-12932.0
OR10W1	-11438.0	-9937.0
OR10X1	-13546.0	-10984.0
OR10Z1	-12433.0	-13895.0
OR11A1	-10083.0	-8124.0
OR11G2	-7374.0	2153.0
OR11H4	-5951.5	3163.5
OR11H6	-4868.0	-1787.0
OR11L1	-7839.0	-2279.0
OR12D2	-12233.5	-7589.0
OR12D3	-12943.0	-12977.0
OR13A1	-13782.0	-13965.0
OR13C2	-13705.0	-8661.5
OR13C3	-13257.0	3564.0
OR13C4	-8486.5	-12751.0
OR13C8	-12784.0	-2781.0
OR13C9	-11168.0	-6074.5
OR13D1	-12826.0	-9896.0
OR13F1	-11074.0	-6373.0
OR13G1	-13967.0	-8784.0
OR13J1	-12291.0	-12030.0
OR14A16	-10770.0	6150.0
OR14C36	-7969.0	-5014.0
OR14I1	-10492.0	-439.0
OR14J1	-8074.0	-4665.0
OR1A1	-12032.0	-12277.0
OR1A2	-10052.0	-10293.0
OR1B1	-192.0	-3622.0
OR1C1	-11724.0	-12532.5
OR1D2	-13137.0	854.0
OR1E1	-5880.5	-593.0
OR1E2	-9684.5	-13634.0
OR1F1	-170.0	-2193.0
OR1G1	-11695.0	-10627.0
OR1I1	-7157.0	-2372.0
OR1J1	-11702.0	-1721.0
OR1J2	-11372.0	-9208.0
OR1J4	2823.0	-9196.0
OR1K1	-8215.0	8325.0
OR1L1	-8180.0	-3931.0
OR1L3	-1942.0	-7384.0
OR1L4	-12316.5	2315.0
OR1L6	-12563.0	3972.0
OR1L8	-11756.0	4410.0
OR1M1	-5690.0	-3004.0
OR1N1	-3215.0	-144.0
OR1N2	-9990.0	-13676.0
OR1Q1	-11203.0	-5420.0
OR1S1	-4461.5	3122.0
OR1S2	-3568.0	-2611.0
OR2A12	-10930.0	-3465.0
OR2A14	-10023.5	-4558.0
OR2A2	-13285.0	-10075.0
OR2A5	-12300.0	-11599.0
OR2AE1	-6064.0	5727.5
OR2AG1	-5320.0	-12728.5
OR2AG2	-8263.0	3848.0
OR2AK2	-13869.5	-9928.0
OR2AP1	-13685.0	-9365.0
OR2AT4	-3362.0	-3964.0
OR2B11	-8948.0	-3953.0
OR2B2	-12449.0	-13174.5
OR2B3	-10044.0	1329.0
OR2B6	-14164.0	-14554.0
OR2C1	7499.0	6300.0
OR2C3	-9574.0	-10185.0
OR2D2	-9922.0	-9998.0
OR2D3	-12068.0	2779.0
OR2F1	-12181.5	-9483.0
OR2F2	-9622.0	-4560.5
OR2G2	-9523.0	2260.0
OR2G3	-13358.0	-9371.0
OR2G6	-9397.0	1126.0
OR2H1	-10076.0	-13043.0
OR2H2	-12949.0	-14463.5
OR2J2	-10745.0	-1564.0
OR2K2	-9199.0	4520.0
OR2L13	-11824.0	-7938.0
OR2L2	-13590.0	-8205.0
OR2L3	-11700.0	-14095.0
OR2L5	-14179.5	-14583.0
OR2L8	-12138.0	-10943.0
OR2M2	-3535.0	-8009.0
OR2M3	-13663.5	-13354.0
OR2M4	-11206.0	-7693.0
OR2M5	-6439.0	-3895.0
OR2M7	-7184.5	-10779.0
OR2S2	-14138.0	-14586.5
OR2T1	-11289.0	6656.0
OR2T11	-6920.0	-7980.0
OR2T12	-13388.0	-9083.5
OR2T27	-733.0	-4967.0
OR2T3	9695.0	-8496.5
OR2T33	-10575.0	-9819.0
OR2T4	-9758.0	-8418.5
OR2T6	-11541.0	-12124.0
OR2T8	-13560.0	-8291.0
OR2V1	-13412.0	-13652.0
OR2V2	242.0	6694.0
OR2W1	-11157.0	-8330.0
OR2W3	-10882.0	-6761.0
OR2Y1	-9647.0	-9063.0
OR2Z1	-3238.0	-763.0
OR3A1	-7453.0	699.0
OR3A2	-5752.0	-4370.0
OR3A3	-12833.0	-10387.0
OR4A15	132.0	-2059.0
OR4A16	-5167.0	-1178.0
OR4A47	8335.0	-8374.0
OR4A5	-11753.0	-2536.5
OR4B1	394.0	1960.0
OR4C12	-10006.0	-8894.0
OR4C15	-7193.5	-2788.0
OR4C16	-7251.0	-9890.0
OR4C3	-1553.0	-3758.0
OR4C45	-9474.0	-2066.0
OR4C46	804.0	-10276.0
OR4C6	60.0	-5097.0
OR4D1	-7400.5	7586.5
OR4D10	-13658.0	-4326.5
OR4D11	-12520.0	-14344.0
OR4D2	-7085.0	-3315.0
OR4D5	-11593.5	-2496.0
OR4D6	-12771.5	-14240.0
OR4D9	-8384.5	-8128.0
OR4E2	-11359.0	-3529.0
OR4F15	-11218.0	-947.0
OR4F6	2909.0	-5587.0
OR4K1	8145.0	5935.0
OR4K13	1853.0	5950.0
OR4K14	9530.0	-3172.0
OR4K15	10194.5	9752.0
OR4K17	441.0	1431.0
OR4K2	-6804.0	-1239.0
OR4K5	-11627.0	4435.5
OR4L1	-8496.5	6080.0
OR4M1	-10985.0	4087.0
OR4N2	-8392.0	3497.0
OR4N5	8260.0	7923.0
OR4S1	-10576.0	-5982.0
OR4X1	331.0	-9270.0
OR4X2	7038.0	-400.0
OR51A2	-9929.0	-5694.0
OR51A7	-11584.0	-13702.0
OR51B2	-11066.0	-13535.0
OR51B4	-13228.0	-12564.0
OR51B5	-11684.0	-12992.0
OR51B6	-12404.0	-14509.0
OR51D1	-13052.0	-13591.0
OR51E1	-11150.0	-11339.0
OR51E2	-12169.0	-6107.0
OR51F1	-10148.0	-12692.0
OR51F2	-12849.0	-14342.0
OR51G1	-7044.0	-12661.0
OR51G2	-12972.0	-14369.0
OR51I1	-8288.0	-9970.0
OR51I2	-8272.0	-1673.0
OR51L1	-13392.0	-12795.0
OR51M1	-12413.5	-10088.0
OR51Q1	1728.0	672.0
OR51S1	-13586.0	-13385.0
OR51T1	-12326.5	-13678.0
OR51V1	-13214.5	-13468.0
OR52A1	-9226.0	-7200.5
OR52A5	-13819.0	-12508.0
OR52B2	-9445.0	-11973.0
OR52B6	-9209.0	1773.0
OR52D1	-11078.5	-5077.0
OR52E2	-8769.0	-11310.0
OR52E4	-9546.0	-8295.0
OR52E6	-12334.5	-14434.0
OR52E8	-12118.0	-4107.0
OR52H1	-12480.0	4714.0
OR52I1	-10285.0	-9989.0
OR52I2	-11460.0	-3851.0
OR52J3	-9550.0	4319.0
OR52K1	-7933.0	635.0
OR52K2	-11648.0	-12148.0
OR52L1	-9239.0	5306.5
OR52M1	-3022.0	-13541.0
OR52N1	-12739.0	-11972.0
OR52N2	-10315.0	1843.0
OR52R1	-10436.0	-12894.5
OR52W1	-2470.0	8591.0
OR56A1	-12711.0	-13624.0
OR56A3	-13271.0	-7069.0
OR56A4	-9918.0	-10286.0
OR56A5	-858.0	-9550.5
OR56B1	-13414.0	-11517.0
OR56B4	-3989.5	-14416.0
OR5A1	-11649.0	-12950.0
OR5A2	-10678.0	-14259.5
OR5AC2	-13454.0	-11226.0
OR5AK2	-13550.0	-12488.0
OR5AN1	-13643.0	-13633.0
OR5AP2	-10236.5	257.0
OR5AR1	-13690.0	-11725.5
OR5AS1	-11134.0	-9258.0
OR5AU1	6864.0	-4477.0
OR5B12	-10475.0	-6349.0
OR5B17	-14199.0	-14820.0
OR5B2	-10010.0	1072.0
OR5B21	-11015.0	-6148.0
OR5B3	-11910.0	-4194.0
OR5C1	-9216.0	2772.0
OR5D13	-8145.5	4802.0
OR5D14	-3222.0	-6467.0
OR5D16	-3057.0	-1420.0
OR5D18	-8578.0	1496.0
OR5F1	-13909.0	2226.0
OR5H1	-3867.0	2041.0
OR5H15	-3702.5	-56.0
OR5H2	-9608.0	-8608.0
OR5H6	-12358.0	-14099.0
OR5I1	-11591.0	-11429.0
OR5J2	-13177.0	-11197.5
OR5K1	-13498.0	4798.0
OR5K2	-13833.0	-1790.0
OR5K3	-12167.5	5163.0
OR5K4	-12298.0	-2767.0
OR5L1	-10393.0	-9711.0
OR5L2	-13894.5	-5446.0
OR5M1	-12973.0	-9504.0
OR5M10	-14063.0	-14624.0
OR5M11	-12199.0	-2873.0
OR5M3	-12506.0	-2794.5
OR5M8	-10957.0	301.5
OR5M9	-13167.0	-163.5
OR5P2	-9681.0	-10050.0
OR5P3	-10599.0	-8779.0
OR5T1	-13956.5	-14262.0
OR5T2	-14102.0	-13808.5
OR5T3	-14072.0	-14217.5
OR5V1	-12159.0	-6641.0
OR5W2	-11307.5	-10811.0
OR6A2	-7818.0	54.0
OR6B1	-9408.0	-11304.0
OR6B2	-12101.0	-13705.0
OR6B3	-12904.0	-14188.0
OR6C1	-14035.0	-3356.0
OR6C2	-13975.0	-9549.0
OR6C3	-11167.0	-4081.0
OR6C4	-11322.0	-13090.0
OR6C6	-8965.0	-1730.0
OR6C65	-13600.0	-9348.0
OR6C68	-9763.0	-2113.0
OR6C70	-12110.0	-3387.0
OR6C74	-13124.0	-11578.5
OR6C75	-14155.0	2765.0
OR6C76	-13450.0	-5853.0
OR6F1	-11727.0	-11156.0
OR6K2	-12173.0	-8993.0
OR6K3	-5636.0	-11791.0
OR6K6	-10915.0	-4126.0
OR6M1	-13237.0	-8169.5
OR6N1	-10032.0	-7573.0
OR6N2	-6939.0	-13215.0
OR6P1	-10220.0	-12617.0
OR6Q1	11054.0	9496.0
OR6S1	-7301.0	-19.0
OR6T1	-12374.0	-6097.0
OR6V1	-11632.0	-12689.0
OR6X1	-12453.0	-13884.0
OR6Y1	-13593.0	-13560.0
OR7A10	-12551.0	-12186.0
OR7A17	-9107.0	-6490.0
OR7A5	-10942.0	-10138.0
OR7C1	-12549.0	-10958.0
OR7C2	-9529.0	-5023.0
OR7D2	-12986.0	840.0
OR7D4	-10610.0	2667.0
OR7E24	2955.5	7817.0
OR7G1	1625.0	287.0
OR7G2	-8587.0	-3159.0
OR7G3	272.0	1475.0
OR8A1	-12810.0	-13825.5
OR8B12	-4054.0	-8848.5
OR8B2	-13705.0	-12365.0
OR8B4	-12717.0	-14249.0
OR8B8	-10252.0	-6620.0
OR8D1	-7439.0	-1668.0
OR8D2	-13105.0	-13907.0
OR8D4	-10854.0	-14259.5
OR8G1	-14048.0	-13553.0
OR8G5	-13631.0	-14124.0
OR8H1	-13728.0	-7016.0
OR8H3	-13192.5	-13489.5
OR8I2	-10154.0	8814.0
OR8J1	-14169.5	-9147.0
OR8J3	-14049.0	-6681.0
OR8K1	-10630.0	-825.0
OR8K3	-10034.0	-4669.0
OR8K5	-13598.0	-8325.0
OR8S1	-7250.0	-4414.0
OR8U1	-13229.0	1265.0
OR8U8	-11031.0	-9309.0
OR9A2	-10187.0	-12537.0
OR9A4	-13216.0	-13897.0
OR9G1	-10878.5	-12259.5
OR9G4	-10231.0	-12495.5
OR9G9	-10878.5	-12259.5
OR9I1	-11026.0	226.0
OR9K2	-11967.0	-13493.0
OR9Q1	5947.0	3223.0
OR9Q2	-7582.0	-8515.0
REEP1	5669.0	-3765.0
RTP1	-2720.0	2497.0
RTP2	-11887.0	-7830.0

---

---

REACTOME_HDL_CLEARANCE

REACTOME_HDL_CLEARANCE

metric	value
setSize	5
pMANOVA	0.0555
p.adjustMANOVA	0.169
s.dist	0.674
s.Discovery	0.266
s.Replication	0.619
p.Discovery	0.303
p.Replication	0.0166

Top 20 genes

Gene	Discovery	Replication
AMN	10657	9943
HDLBP	2133	6423

Click HERE to show all gene set members

All member genes

	Discovery	Replication
AMN	10657	9943
APOA1	-830	296
CUBN	-515	4492
HDLBP	2133	6423
SCARB1	-2167	7371

---

---

REACTOME_DEFECTIVE_ST3GAL3_CAUSES_MCT12_AND_EIEE15

REACTOME_DEFECTIVE_ST3GAL3_CAUSES_MCT12_AND_EIEE15

metric	value
setSize	8
pMANOVA	0.00922
p.adjustMANOVA	0.0485
s.dist	0.668
s.Discovery	-0.621
s.Replication	-0.248
p.Discovery	0.00237
p.Replication	0.224

Top 20 genes

Gene	Discovery	Replication
LUM	-13221	-14200
KERA	-13284	-11971
FMOD	-11028	-11828
PRELP	-9718	-11847
ACAN	-1126	-3319

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ACAN	-1126	-3319
FMOD	-11028	-11828
KERA	-13284	-11971
LUM	-13221	-14200
OGN	-13966	5722
OMD	-13582	653
PRELP	-9718	-11847
ST3GAL3	810	4469

---

---

REACTOME_CREATINE_METABOLISM

REACTOME_CREATINE_METABOLISM

metric	value
setSize	9
pMANOVA	0.0205
p.adjustMANOVA	0.0876
s.dist	0.658
s.Discovery	0.457
s.Replication	0.474
p.Discovery	0.0176
p.Replication	0.0139

Top 20 genes

Gene	Discovery	Replication
CKB	10562	9830
GATM	9779	9174
SLC6A11	9195	8337
GAMT	9580	7342
CKMT2	7065	8188
CKM	8170	2927
SLC6A7	7066	135

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CKB	10562.0	9830
CKM	8170.0	2927
CKMT1B	-12999.5	1777
CKMT2	7065.0	8188
GAMT	9580.0	7342
GATM	9779.0	9174
SLC6A11	9195.0	8337
SLC6A12	-9949.0	-12929
SLC6A7	7066.0	135

---

---

REACTOME_TFAP2_AP_2_FAMILY_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_FACTORS

REACTOME_TFAP2_AP_2_FAMILY_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_FACTORS

metric	value
setSize	5
pMANOVA	0.0823
p.adjustMANOVA	0.22
s.dist	0.658
s.Discovery	0.576
s.Replication	0.317
p.Discovery	0.0256
p.Replication	0.219

Top 20 genes

Gene	Discovery	Replication
TFAP2A	10931	10230
TFAP2C	10836	10243
KDM5B	5841	2924

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CDKN1A	-4183	-4139
KDM5B	5841	2924
MYC	5518	-9847
TFAP2A	10931	10230
TFAP2C	10836	10243

---

---

REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

metric	value
setSize	7
pMANOVA	0.00562
p.adjustMANOVA	0.0336
s.dist	0.656
s.Discovery	0.095
s.Replication	0.649
p.Discovery	0.663
p.Replication	0.00294

Top 20 genes

Gene	Discovery	Replication
AGO1	10642	10187
TNRC6B	8375	5952

Click HERE to show all gene set members

All member genes

	Discovery	Replication
AGO1	10642	10187
AGO2	-851	9068
AGO3	-3628	1780
AGO4	-8729	5984
TNRC6A	-2870	3915
TNRC6B	8375	5952
TNRC6C	-5148	5737

---

---

REACTOME_NGF_INDEPENDANT_TRKA_ACTIVATION

REACTOME_NGF_INDEPENDANT_TRKA_ACTIVATION

metric	value
setSize	5
pMANOVA	0.103
p.adjustMANOVA	0.253
s.dist	0.656
s.Discovery	0.537
s.Replication	0.376
p.Discovery	0.0375
p.Replication	0.145

Top 20 genes

Gene	Discovery	Replication
ADCYAP1	10762	9812
ADORA2A	7895	9610
NTRK2	8234	4139

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ADCYAP1	10762	9812
ADCYAP1R1	-2342	-5637
ADORA2A	7895	9610
NTRK1	1924	-4781
NTRK2	8234	4139

---

---

REACTOME_NEF_AND_SIGNAL_TRANSDUCTION

REACTOME_NEF_AND_SIGNAL_TRANSDUCTION

metric	value
setSize	8
pMANOVA	0.0305
p.adjustMANOVA	0.113
s.dist	0.654
s.Discovery	0.509
s.Replication	0.411
p.Discovery	0.0127
p.Replication	0.0441

Top 20 genes

Gene	Discovery	Replication
CD247	10011	9238
LCK	9759	7106
PAK2	6766	6738
DOCK2	1390	6951
ELMO1	1142	4839
RAC1	6749	101

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CD247	10011	9238
DOCK2	1390	6951
ELMO1	1142	4839
FYN	485	-4218
HCK	3157	-6202
LCK	9759	7106
PAK2	6766	6738
RAC1	6749	101

---

---

REACTOME_DEFECTIVE_B4GALT1_CAUSES_B4GALT1_CDG_CDG_2D

REACTOME_DEFECTIVE_B4GALT1_CAUSES_B4GALT1_CDG_CDG_2D

metric	value
setSize	8
pMANOVA	0.0196
p.adjustMANOVA	0.0852
s.dist	0.653
s.Discovery	-0.572
s.Replication	-0.317
p.Discovery	0.00511
p.Replication	0.121

Top 20 genes

Gene	Discovery	Replication
LUM	-13221	-14200
KERA	-13284	-11971
FMOD	-11028	-11828
PRELP	-9718	-11847
ACAN	-1126	-3319

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ACAN	-1126	-3319
B4GALT1	5773	-2463
FMOD	-11028	-11828
KERA	-13284	-11971
LUM	-13221	-14200
OGN	-13966	5722
OMD	-13582	653
PRELP	-9718	-11847

---

---

REACTOME_CIPROFLOXACIN_ADME

REACTOME_CIPROFLOXACIN_ADME

metric	value
setSize	5
pMANOVA	0.0804
p.adjustMANOVA	0.218
s.dist	0.65
s.Discovery	-0.58
s.Replication	-0.293
p.Discovery	0.0247
p.Replication	0.256

Top 20 genes

Gene	Discovery	Replication
SLC22A8	-11145	-13227
ALB	-13483	-5582
SLCO1A2	-9592	-6696
ABCG2	-4407	-11162

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ABCG2	-4407	-11162
ALB	-13483	-5582
SLC22A1	-5743	7357
SLC22A8	-11145	-13227
SLCO1A2	-9592	-6696

---

---

REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS

REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS

metric	value
setSize	18
pMANOVA	0.000178
p.adjustMANOVA	0.0017
s.dist	0.646
s.Discovery	-0.565
s.Replication	-0.313
p.Discovery	3.35e-05
p.Replication	0.0215

Top 20 genes

Gene	Discovery	Replication
BAAT	-13176.0	-13839.0
FABP6	-11650.0	-13959.0
SLCO1B1	-9486.0	-13808.5
NR1H4	-9860.0	-12248.0
SLC51B	-12148.5	-9746.0
SLC51A	-10521.0	-9132.0
ABCB11	-8628.0	-9841.5
ALB	-13483.0	-5582.0
ABCC3	-8100.0	-8354.0
STARD5	-5840.0	-11010.0
SLCO1A2	-9592.0	-6696.0
SLC10A1	-8658.0	-6776.0
SLCO1B3	-13503.0	-2491.0
RXRA	-8736.0	-2354.0

Click HERE to show all gene set members

All member genes

	Discovery	Replication
ABCB11	-8628.0	-9841.5
ABCC3	-8100.0	-8354.0
ALB	-13483.0	-5582.0
BAAT	-13176.0	-13839.0
FABP6	-11650.0	-13959.0
NCOA1	-9319.0	4202.0
NCOA2	-4723.0	676.0
NR1H4	-9860.0	-12248.0
RXRA	-8736.0	-2354.0
SLC10A1	-8658.0	-6776.0
SLC10A2	8492.0	4259.0
SLC27A5	-7271.0	6757.0
SLC51A	-10521.0	-9132.0
SLC51B	-12148.5	-9746.0
SLCO1A2	-9592.0	-6696.0
SLCO1B1	-9486.0	-13808.5
SLCO1B3	-13503.0	-2491.0
STARD5	-5840.0	-11010.0

---

---

REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION

REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION

metric	value
setSize	16
pMANOVA	0.00137
p.adjustMANOVA	0.0104
s.dist	0.643
s.Discovery	0.442
s.Replication	0.467
p.Discovery	0.00223
p.Replication	0.00122

Top 20 genes

Gene	Discovery	Replication
SOX2	10993	10255
BMP4	10898	10280
GSC	10939	10177
TCF7	9607	8840
LEF1	9536	8793
FOXH1	9400	7937
SMAD2	8647	8398
MIXL1	9300	6856
EOMES	9585	3307
SMAD3	2826	3512

Click HERE to show all gene set members

All member genes

	Discovery	Replication
BMP4	10898	10280.0
CTNNB1	-5776	3825.0
EOMES	9585	3307.0
FOXH1	9400	7937.0
GSC	10939	10177.0
LEF1	9536	8793.0
MIXL1	9300	6856.0
NANOG	-11024	-13199.0
POU5F1	-8505	3304.5
SMAD2	8647	8398.0
SMAD3	2826	3512.0
SMAD4	-43	-7768.0
SOX2	10993	10255.0
TBPL2	3903	-3284.0
TCF7	9607	8840.0
TRIM33	-5052	-812.0

---

---

REACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES

REACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES

metric	value
setSize	7
pMANOVA	0.0541
p.adjustMANOVA	0.167
s.dist	0.642
s.Discovery	0.492
s.Replication	0.412
p.Discovery	0.0243
p.Replication	0.0589

Top 20 genes

Gene	Discovery	Replication
TKT	7469	7734
MAFG	7276	4407
CREBBP	2515	7619
TALDO1	3024	4147

Click HERE to show all gene set members

All member genes

	Discovery	Replication
CREBBP	2515	7619
EP300	-1546	845
MAFG	7276	4407
NFE2L2	5659	-1916
PGD	8609	-1235
TALDO1	3024	4147
TKT	7469	7734

---

---

REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE

REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE

metric	value
setSize	6
pMANOVA	0.0348
p.adjustMANOVA	0.123
s.dist	0.637
s.Discovery	-0.601
s.Replication	-0.21
p.Discovery	0.0107
p.Replication	0.372

Top 20 genes

Gene	Discovery	Replication
TREH	-13484.0	-13224.0
MGAM	-12932.0	-13497.0
CHIT1	-12348.0	-13256.5
CHIA	-9274.5	-1006.0

Click HERE to show all gene set members

All member genes

	Discovery	Replication
AMY2B	-10217.0	5885.0
CHIA	-9274.5	-1006.0
CHIT1	-12348.0	-13256.5
LCT	3370.0	6232.0
MGAM	-12932.0	-13497.0
TREH	-13484.0	-13224.0

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.3                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.4.4                                      
##  [4] reshape2_1.4.4                                     
##  [5] gtools_3.9.4                                       
##  [6] tibble_3.2.1                                       
##  [7] dplyr_1.1.3                                        
##  [8] echarts4r_0.4.5                                    
##  [9] png_0.1-8                                          
## [10] gridExtra_2.3                                      
## [11] missMethyl_1.36.0                                  
## [12] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [13] beeswarm_0.4.0                                     
## [14] kableExtra_1.3.4                                   
## [15] gplots_3.1.3                                       
## [16] mitch_1.15.0                                       
## [17] tictoc_1.2                                         
## [18] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] minfi_1.48.0                                       
## [21] bumphunter_1.44.0                                  
## [22] locfit_1.5-9.8                                     
## [23] iterators_1.0.14                                   
## [24] foreach_1.5.2                                      
## [25] Biostrings_2.70.1                                  
## [26] XVector_0.42.0                                     
## [27] SummarizedExperiment_1.32.0                        
## [28] Biobase_2.62.0                                     
## [29] MatrixGenerics_1.14.0                              
## [30] matrixStats_1.1.0                                  
## [31] GenomicRanges_1.54.1                               
## [32] GenomeInfoDb_1.38.1                                
## [33] IRanges_2.36.0                                     
## [34] S4Vectors_0.40.1                                   
## [35] BiocGenerics_0.48.1                                
## [36] eulerr_7.0.0                                       
## [37] limma_3.58.1                                       
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.3.2             later_1.3.1              
##   [3] BiocIO_1.12.0             bitops_1.0-7             
##   [5] filelock_1.0.2            preprocessCore_1.64.0    
##   [7] XML_3.99-0.15             lifecycle_1.0.4          
##   [9] lattice_0.22-5            MASS_7.3-60              
##  [11] base64_2.0.1              scrime_1.3.5             
##  [13] magrittr_2.0.3            sass_0.4.7               
##  [15] rmarkdown_2.25            jquerylib_0.1.4          
##  [17] yaml_2.3.7                httpuv_1.6.12            
##  [19] doRNG_1.8.6               askpass_1.2.0            
##  [21] DBI_1.1.3                 RColorBrewer_1.1-3       
##  [23] abind_1.4-5               zlibbioc_1.48.0          
##  [25] rvest_1.0.3               quadprog_1.5-8           
##  [27] purrr_1.0.2               RCurl_1.98-1.13          
##  [29] rappdirs_0.3.3            GenomeInfoDbData_1.2.11  
##  [31] genefilter_1.84.0         annotate_1.80.0          
##  [33] svglite_2.1.2             DelayedMatrixStats_1.24.0
##  [35] codetools_0.2-19          DelayedArray_0.28.0      
##  [37] xml2_1.3.5                tidyselect_1.2.0         
##  [39] farver_2.1.1              beanplot_1.3.1           
##  [41] BiocFileCache_2.10.1      webshot_0.5.5            
##  [43] illuminaio_0.44.0         GenomicAlignments_1.38.0 
##  [45] jsonlite_1.8.7            multtest_2.58.0          
##  [47] ellipsis_0.3.2            survival_3.5-7           
##  [49] systemfonts_1.0.5         tools_4.3.2              
##  [51] progress_1.2.2            Rcpp_1.0.11              
##  [53] glue_1.6.2                SparseArray_1.2.2        
##  [55] xfun_0.41                 HDF5Array_1.30.0         
##  [57] withr_2.5.2               fastmap_1.1.1            
##  [59] rhdf5filters_1.14.1       fansi_1.0.5              
##  [61] openssl_2.1.1             caTools_1.18.2           
##  [63] digest_0.6.33             R6_2.5.1                 
##  [65] mime_0.12                 colorspace_2.1-0         
##  [67] biomaRt_2.58.0            RSQLite_2.3.3            
##  [69] utf8_1.2.4                tidyr_1.3.0              
##  [71] generics_0.1.3            data.table_1.14.8        
##  [73] rtracklayer_1.62.0        prettyunits_1.2.0        
##  [75] httr_1.4.7                htmlwidgets_1.6.2        
##  [77] S4Arrays_1.2.0            pkgconfig_2.0.3          
##  [79] gtable_0.3.4              blob_1.2.4               
##  [81] siggenes_1.76.0           htmltools_0.5.7          
##  [83] scales_1.2.1              knitr_1.45               
##  [85] rstudioapi_0.15.0         tzdb_0.4.0               
##  [87] rjson_0.2.21              nlme_3.1-163             
##  [89] curl_5.1.0                org.Hs.eg.db_3.18.0      
##  [91] cachem_1.0.8              rhdf5_2.46.0             
##  [93] stringr_1.5.0             KernSmooth_2.23-22       
##  [95] AnnotationDbi_1.64.1      restfulr_0.0.15          
##  [97] GEOquery_2.70.0           pillar_1.9.0             
##  [99] grid_4.3.2                reshape_0.8.9            
## [101] vctrs_0.6.4               promises_1.2.1           
## [103] dbplyr_2.4.0              xtable_1.8-4             
## [105] evaluate_0.23             readr_2.1.4              
## [107] GenomicFeatures_1.54.1    cli_3.6.1                
## [109] compiler_4.3.2            Rsamtools_2.18.0         
## [111] rlang_1.1.2               crayon_1.5.2             
## [113] rngtools_1.5.2            labeling_0.4.3           
## [115] nor1mix_1.3-0             mclust_6.0.0             
## [117] plyr_1.8.9                stringi_1.7.12           
## [119] viridisLite_0.4.2         BiocParallel_1.36.0      
## [121] munsell_0.5.0             Matrix_1.6-2             
## [123] hms_1.1.3                 sparseMatrixStats_1.14.0 
## [125] bit64_4.0.5               Rhdf5lib_1.24.0          
## [127] KEGGREST_1.42.0           statmod_1.5.0            
## [129] shiny_1.7.5.1             highr_0.10               
## [131] memoise_2.0.1             bslib_0.5.1              
## [133] bit_4.0.5

END of report