date generated: 2020-10-22

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             human      mouse
## A4GALT -14.988939  0.8182771
## AAAS    -2.435804  0.3877972
## AACS    -1.581711  4.1420212
## AAED1   -1.286093 -0.8848853
## AAGAB   -1.722220 -1.3839648
## AAK1    14.833940  0.4269837

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 10654
duplicated_genes_present 0
num_profile_genes_in_sets 6218
num_profile_genes_not_in_sets 4436
profile_pearson_correl NaN
profile_spearman_correl 0.16715

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2408
num_genesets_excluded 1175
num_genesets_included 1233

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 411

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.human s.mouse p.human p.mouse
Interleukin-10 signaling 11 8.92e-06 8.00e-05 0.789 -0.2520 0.747 1.48e-01 1.76e-05
Post-chaperonin tubulin folding pathway 15 4.53e-07 6.03e-06 0.736 -0.4830 0.555 1.21e-03 1.96e-04
Carnitine metabolism 11 7.01e-04 3.66e-03 0.714 -0.4340 -0.568 1.27e-02 1.12e-03
rRNA modification in the nucleus and cytosol 52 3.48e-15 3.30e-13 0.698 0.6000 0.356 7.07e-14 8.87e-06
Formation of tubulin folding intermediates by CCT/TriC 17 2.18e-06 2.38e-05 0.690 -0.0952 0.683 4.97e-01 1.08e-06
Signal regulatory protein family interactions 10 4.69e-04 2.51e-03 0.654 -0.4120 0.507 2.41e-02 5.48e-03
Regulation of pyruvate dehydrogenase (PDH) complex 15 1.21e-04 8.00e-04 0.651 -0.1620 -0.631 2.77e-01 2.33e-05
Postmitotic nuclear pore complex (NPC) reformation 24 2.04e-06 2.25e-05 0.646 0.5430 0.350 4.11e-06 2.97e-03
Citric acid cycle (TCA cycle) 21 7.05e-06 6.48e-05 0.644 -0.2430 -0.597 5.39e-02 2.22e-06
Mitochondrial Fatty Acid Beta-Oxidation 30 8.79e-08 1.51e-06 0.643 -0.3360 -0.548 1.48e-03 2.05e-07
Voltage gated Potassium channels 11 2.82e-03 1.15e-02 0.640 -0.5290 -0.362 2.41e-03 3.79e-02
Transport of the SLBP Dependant Mature mRNA 29 1.89e-07 2.65e-06 0.635 0.5560 0.307 2.20e-07 4.19e-03
Striated Muscle Contraction 30 5.73e-08 1.02e-06 0.631 -0.6030 -0.187 1.10e-08 7.60e-02
Phase 0 - rapid depolarisation 18 6.59e-05 4.67e-04 0.628 -0.5790 -0.242 2.11e-05 7.58e-02
Transport of the SLBP independent Mature mRNA 28 4.83e-07 6.33e-06 0.625 0.5560 0.285 3.58e-07 9.15e-03
Pyruvate metabolism and Citric Acid (TCA) cycle 49 1.25e-11 4.99e-10 0.618 -0.2630 -0.559 1.45e-03 1.28e-11
Gluconeogenesis 23 9.76e-06 8.60e-05 0.617 -0.5350 -0.306 8.82e-06 1.11e-02
Export of Viral Ribonucleoproteins from Nucleus 26 2.73e-06 2.85e-05 0.608 0.5420 0.275 1.69e-06 1.54e-02
Transport of Ribonucleoproteins into the Host Nucleus 25 5.04e-06 4.81e-05 0.605 0.5410 0.270 2.84e-06 1.97e-02
Metabolism of non-coding RNA 45 2.20e-10 7.14e-09 0.604 0.5560 0.236 1.10e-10 6.24e-03
snRNP Assembly 45 2.20e-10 7.14e-09 0.604 0.5560 0.236 1.10e-10 6.24e-03
Nuclear import of Rev protein 26 3.89e-06 3.90e-05 0.600 0.5330 0.275 2.52e-06 1.53e-02
SUMOylation of SUMOylation proteins 27 2.26e-06 2.45e-05 0.599 0.5420 0.254 1.08e-06 2.26e-02
Glycogen breakdown (glycogenolysis) 14 1.24e-03 5.94e-03 0.597 -0.5380 -0.259 4.92e-04 9.36e-02
SUMOylation of ubiquitinylation proteins 31 4.54e-07 6.03e-06 0.595 0.5300 0.270 3.33e-07 9.22e-03
Heme biosynthesis 12 2.28e-03 9.71e-03 0.595 -0.1280 -0.581 4.44e-01 4.96e-04
Mitochondrial tRNA aminoacylation 18 2.34e-05 1.85e-04 0.592 0.1780 -0.565 1.90e-01 3.38e-05
Interactions of Rev with host cellular proteins 29 1.74e-06 1.95e-05 0.592 0.4990 0.318 3.39e-06 3.02e-03
SUMOylation of DNA replication proteins 35 1.17e-07 1.85e-06 0.591 0.4990 0.316 3.30e-07 1.21e-03
mRNA Splicing - Major Pathway 161 1.60e-32 5.11e-30 0.590 0.5080 0.300 1.02e-28 6.21e-11
Prolactin receptor signaling 10 9.27e-03 3.11e-02 0.590 -0.2470 -0.536 1.77e-01 3.36e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 23 2.17e-05 1.73e-04 0.588 0.5380 0.235 7.84e-06 5.09e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 23 2.17e-05 1.73e-04 0.588 0.5380 0.235 7.84e-06 5.09e-02
NEP/NS2 Interacts with the Cellular Export Machinery 25 1.26e-05 1.09e-04 0.580 0.5250 0.245 5.54e-06 3.38e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript 60 2.20e-12 1.04e-10 0.579 0.5200 0.254 3.24e-12 6.83e-04
ABC transporters in lipid homeostasis 11 5.06e-03 1.88e-02 0.579 -0.1230 -0.566 4.80e-01 1.16e-03
Rev-mediated nuclear export of HIV RNA 28 4.91e-06 4.76e-05 0.577 0.4900 0.306 7.25e-06 5.14e-03
mRNA Splicing 169 1.66e-32 5.11e-30 0.575 0.5010 0.283 3.50e-29 2.56e-10
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.53e-02 4.70e-02 0.570 -0.3790 -0.426 3.79e-02 1.98e-02
Processing of Capped Intron-Containing Pre-mRNA 212 7.36e-40 4.54e-37 0.569 0.5000 0.272 5.18e-36 9.76e-12
Pyruvate metabolism 26 1.13e-05 9.82e-05 0.569 -0.2280 -0.522 4.43e-02 4.16e-06
Vpr-mediated nuclear import of PICs 27 9.98e-06 8.73e-05 0.569 0.4920 0.286 9.70e-06 1.01e-02
Reduction of cytosolic Ca++ levels 10 1.18e-02 3.88e-02 0.569 -0.5320 -0.202 3.59e-03 2.69e-01
Interactions of Vpr with host cellular proteins 29 8.96e-06 8.00e-05 0.552 0.4760 0.280 9.21e-06 9.20e-03
Viral Messenger RNA Synthesis 35 9.00e-07 1.11e-05 0.552 0.4660 0.295 1.85e-06 2.53e-03
Transport of Mature mRNAs Derived from Intronless Transcripts 36 6.14e-07 7.69e-06 0.551 0.4680 0.290 1.16e-06 2.62e-03
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 10 1.26e-02 4.04e-02 0.551 0.1090 0.540 5.49e-01 3.13e-03
HIV Transcription Initiation 40 1.50e-07 2.17e-06 0.550 0.4520 0.313 7.48e-07 6.22e-04
RNA Polymerase II HIV Promoter Escape 40 1.50e-07 2.17e-06 0.550 0.4520 0.313 7.48e-07 6.22e-04
RNA Polymerase II Promoter Escape 40 1.50e-07 2.17e-06 0.550 0.4520 0.313 7.48e-07 6.22e-04


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.human s.mouse p.human p.mouse
Interleukin-10 signaling 11 8.92e-06 8.00e-05 0.78900 -0.252000 0.747000 1.48e-01 1.76e-05
Post-chaperonin tubulin folding pathway 15 4.53e-07 6.03e-06 0.73600 -0.483000 0.555000 1.21e-03 1.96e-04
Carnitine metabolism 11 7.01e-04 3.66e-03 0.71400 -0.434000 -0.568000 1.27e-02 1.12e-03
rRNA modification in the nucleus and cytosol 52 3.48e-15 3.30e-13 0.69800 0.600000 0.356000 7.07e-14 8.87e-06
Formation of tubulin folding intermediates by CCT/TriC 17 2.18e-06 2.38e-05 0.69000 -0.095200 0.683000 4.97e-01 1.08e-06
Signal regulatory protein family interactions 10 4.69e-04 2.51e-03 0.65400 -0.412000 0.507000 2.41e-02 5.48e-03
Regulation of pyruvate dehydrogenase (PDH) complex 15 1.21e-04 8.00e-04 0.65100 -0.162000 -0.631000 2.77e-01 2.33e-05
Postmitotic nuclear pore complex (NPC) reformation 24 2.04e-06 2.25e-05 0.64600 0.543000 0.350000 4.11e-06 2.97e-03
Citric acid cycle (TCA cycle) 21 7.05e-06 6.48e-05 0.64400 -0.243000 -0.597000 5.39e-02 2.22e-06
Mitochondrial Fatty Acid Beta-Oxidation 30 8.79e-08 1.51e-06 0.64300 -0.336000 -0.548000 1.48e-03 2.05e-07
Voltage gated Potassium channels 11 2.82e-03 1.15e-02 0.64000 -0.529000 -0.362000 2.41e-03 3.79e-02
Transport of the SLBP Dependant Mature mRNA 29 1.89e-07 2.65e-06 0.63500 0.556000 0.307000 2.20e-07 4.19e-03
Striated Muscle Contraction 30 5.73e-08 1.02e-06 0.63100 -0.603000 -0.187000 1.10e-08 7.60e-02
Phase 0 - rapid depolarisation 18 6.59e-05 4.67e-04 0.62800 -0.579000 -0.242000 2.11e-05 7.58e-02
Transport of the SLBP independent Mature mRNA 28 4.83e-07 6.33e-06 0.62500 0.556000 0.285000 3.58e-07 9.15e-03
Pyruvate metabolism and Citric Acid (TCA) cycle 49 1.25e-11 4.99e-10 0.61800 -0.263000 -0.559000 1.45e-03 1.28e-11
Gluconeogenesis 23 9.76e-06 8.60e-05 0.61700 -0.535000 -0.306000 8.82e-06 1.11e-02
Export of Viral Ribonucleoproteins from Nucleus 26 2.73e-06 2.85e-05 0.60800 0.542000 0.275000 1.69e-06 1.54e-02
Transport of Ribonucleoproteins into the Host Nucleus 25 5.04e-06 4.81e-05 0.60500 0.541000 0.270000 2.84e-06 1.97e-02
Metabolism of non-coding RNA 45 2.20e-10 7.14e-09 0.60400 0.556000 0.236000 1.10e-10 6.24e-03
snRNP Assembly 45 2.20e-10 7.14e-09 0.60400 0.556000 0.236000 1.10e-10 6.24e-03
Nuclear import of Rev protein 26 3.89e-06 3.90e-05 0.60000 0.533000 0.275000 2.52e-06 1.53e-02
SUMOylation of SUMOylation proteins 27 2.26e-06 2.45e-05 0.59900 0.542000 0.254000 1.08e-06 2.26e-02
Glycogen breakdown (glycogenolysis) 14 1.24e-03 5.94e-03 0.59700 -0.538000 -0.259000 4.92e-04 9.36e-02
SUMOylation of ubiquitinylation proteins 31 4.54e-07 6.03e-06 0.59500 0.530000 0.270000 3.33e-07 9.22e-03
Heme biosynthesis 12 2.28e-03 9.71e-03 0.59500 -0.128000 -0.581000 4.44e-01 4.96e-04
Mitochondrial tRNA aminoacylation 18 2.34e-05 1.85e-04 0.59200 0.178000 -0.565000 1.90e-01 3.38e-05
Interactions of Rev with host cellular proteins 29 1.74e-06 1.95e-05 0.59200 0.499000 0.318000 3.39e-06 3.02e-03
SUMOylation of DNA replication proteins 35 1.17e-07 1.85e-06 0.59100 0.499000 0.316000 3.30e-07 1.21e-03
mRNA Splicing - Major Pathway 161 1.60e-32 5.11e-30 0.59000 0.508000 0.300000 1.02e-28 6.21e-11
Prolactin receptor signaling 10 9.27e-03 3.11e-02 0.59000 -0.247000 -0.536000 1.77e-01 3.36e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 23 2.17e-05 1.73e-04 0.58800 0.538000 0.235000 7.84e-06 5.09e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 23 2.17e-05 1.73e-04 0.58800 0.538000 0.235000 7.84e-06 5.09e-02
NEP/NS2 Interacts with the Cellular Export Machinery 25 1.26e-05 1.09e-04 0.58000 0.525000 0.245000 5.54e-06 3.38e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript 60 2.20e-12 1.04e-10 0.57900 0.520000 0.254000 3.24e-12 6.83e-04
ABC transporters in lipid homeostasis 11 5.06e-03 1.88e-02 0.57900 -0.123000 -0.566000 4.80e-01 1.16e-03
Rev-mediated nuclear export of HIV RNA 28 4.91e-06 4.76e-05 0.57700 0.490000 0.306000 7.25e-06 5.14e-03
mRNA Splicing 169 1.66e-32 5.11e-30 0.57500 0.501000 0.283000 3.50e-29 2.56e-10
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.53e-02 4.70e-02 0.57000 -0.379000 -0.426000 3.79e-02 1.98e-02
Processing of Capped Intron-Containing Pre-mRNA 212 7.36e-40 4.54e-37 0.56900 0.500000 0.272000 5.18e-36 9.76e-12
Pyruvate metabolism 26 1.13e-05 9.82e-05 0.56900 -0.228000 -0.522000 4.43e-02 4.16e-06
Vpr-mediated nuclear import of PICs 27 9.98e-06 8.73e-05 0.56900 0.492000 0.286000 9.70e-06 1.01e-02
Reduction of cytosolic Ca++ levels 10 1.18e-02 3.88e-02 0.56900 -0.532000 -0.202000 3.59e-03 2.69e-01
Interactions of Vpr with host cellular proteins 29 8.96e-06 8.00e-05 0.55200 0.476000 0.280000 9.21e-06 9.20e-03
Viral Messenger RNA Synthesis 35 9.00e-07 1.11e-05 0.55200 0.466000 0.295000 1.85e-06 2.53e-03
Transport of Mature mRNAs Derived from Intronless Transcripts 36 6.14e-07 7.69e-06 0.55100 0.468000 0.290000 1.16e-06 2.62e-03
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 10 1.26e-02 4.04e-02 0.55100 0.109000 0.540000 5.49e-01 3.13e-03
HIV Transcription Initiation 40 1.50e-07 2.17e-06 0.55000 0.452000 0.313000 7.48e-07 6.22e-04
RNA Polymerase II HIV Promoter Escape 40 1.50e-07 2.17e-06 0.55000 0.452000 0.313000 7.48e-07 6.22e-04
RNA Polymerase II Promoter Escape 40 1.50e-07 2.17e-06 0.55000 0.452000 0.313000 7.48e-07 6.22e-04
RNA Polymerase II Transcription Initiation 40 1.50e-07 2.17e-06 0.55000 0.452000 0.313000 7.48e-07 6.22e-04
RNA Polymerase II Transcription Initiation And Promoter Clearance 40 1.50e-07 2.17e-06 0.55000 0.452000 0.313000 7.48e-07 6.22e-04
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 40 1.50e-07 2.17e-06 0.55000 0.452000 0.313000 7.48e-07 6.22e-04
Transport of Mature Transcript to Cytoplasm 69 1.18e-12 5.82e-11 0.54900 0.480000 0.267000 5.44e-12 1.28e-04
Glyoxylate metabolism and glycine degradation 20 3.14e-04 1.76e-03 0.54000 -0.172000 -0.511000 1.83e-01 7.54e-05
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 1.67e-03 7.56e-03 0.53900 -0.167000 0.513000 2.98e-01 1.37e-03
Transport of Mature mRNA Derived from an Intronless Transcript 35 1.55e-06 1.77e-05 0.53900 0.466000 0.271000 1.87e-06 5.50e-03
p130Cas linkage to MAPK signaling for integrins 10 7.83e-03 2.68e-02 0.53800 -0.141000 0.520000 4.39e-01 4.44e-03
RNA Polymerase II Pre-transcription Events 69 6.37e-12 2.80e-10 0.53800 0.432000 0.320000 5.54e-10 4.29e-06
Branched-chain amino acid catabolism 20 2.10e-04 1.28e-03 0.53700 -0.074400 -0.531000 5.65e-01 3.89e-05
NS1 Mediated Effects on Host Pathways 31 8.85e-06 8.00e-05 0.53600 0.451000 0.289000 1.37e-05 5.35e-03
Role of LAT2/NTAL/LAB on calcium mobilization 11 1.35e-02 4.22e-02 0.53600 0.200000 0.497000 2.50e-01 4.33e-03
Biotin transport and metabolism 10 1.27e-02 4.04e-02 0.53600 -0.020100 -0.535000 9.12e-01 3.39e-03
Cyclin A/B1/B2 associated events during G2/M transition 17 1.93e-03 8.43e-03 0.53500 0.395000 0.361000 4.83e-03 9.99e-03
Ion homeostasis 37 1.06e-06 1.26e-05 0.53500 -0.442000 -0.301000 3.30e-06 1.54e-03
Transcription of the HIV genome 59 3.31e-10 9.94e-09 0.53500 0.436000 0.310000 7.27e-09 3.94e-05
Prefoldin mediated transfer of substrate to CCT/TriC 22 1.28e-04 8.35e-04 0.53500 0.124000 0.520000 3.16e-01 2.42e-05
Defects in vitamin and cofactor metabolism 17 3.57e-04 1.96e-03 0.53300 0.105000 -0.523000 4.53e-01 1.90e-04
Cardiac conduction 63 1.05e-10 3.71e-09 0.52800 -0.449000 -0.278000 7.15e-10 1.40e-04
Interaction between L1 and Ankyrins 15 3.87e-03 1.52e-02 0.52800 -0.467000 -0.245000 1.73e-03 1.00e-01
Major pathway of rRNA processing in the nucleolus and cytosol 134 2.69e-21 5.53e-19 0.52700 0.358000 0.386000 8.79e-13 1.42e-14
EGR2 and SOX10-mediated initiation of Schwann cell myelination 20 5.36e-05 3.89e-04 0.52500 -0.423000 0.310000 1.07e-03 1.63e-02
Defective B3GAT3 causes JDSSDHD 14 1.42e-03 6.61e-03 0.52500 -0.495000 0.174000 1.35e-03 2.59e-01
rRNA processing in the nucleus and cytosol 143 2.44e-22 6.01e-20 0.52300 0.367000 0.372000 4.03e-14 1.75e-14
Response of Mtb to phagocytosis 18 1.70e-03 7.64e-03 0.52000 0.273000 0.442000 4.50e-02 1.16e-03
Pausing and recovery of Tat-mediated HIV elongation 25 1.57e-04 9.89e-04 0.52000 0.300000 0.424000 9.46e-03 2.42e-04
Tat-mediated HIV elongation arrest and recovery 25 1.57e-04 9.89e-04 0.52000 0.300000 0.424000 9.46e-03 2.42e-04
Muscle contraction 120 4.80e-20 8.45e-18 0.51800 -0.493000 -0.157000 1.12e-20 3.11e-03
ATF6 (ATF6-alpha) activates chaperone genes 10 2.21e-02 6.10e-02 0.51700 0.117000 0.503000 5.21e-01 5.85e-03
Long-term potentiation 10 2.10e-02 5.90e-02 0.51600 -0.508000 -0.093500 5.46e-03 6.09e-01
SUMOylation of RNA binding proteins 38 1.63e-06 1.84e-05 0.51500 0.452000 0.247000 1.46e-06 8.38e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 24 8.87e-05 6.03e-04 0.51400 0.067500 0.509000 5.67e-01 1.58e-05
mRNA 3'-end processing 49 5.72e-08 1.02e-06 0.51300 0.417000 0.298000 4.52e-07 3.06e-04
Defective B4GALT7 causes EDS, progeroid type 14 2.16e-03 9.30e-03 0.51200 -0.494000 0.136000 1.39e-03 3.79e-01
Signaling by FGFR2 IIIa TM 16 4.51e-03 1.72e-02 0.51100 0.305000 0.409000 3.46e-02 4.59e-03
Attenuation phase 20 1.23e-03 5.89e-03 0.51000 0.329000 0.390000 1.09e-02 2.53e-03
Degradation of cysteine and homocysteine 12 1.84e-02 5.33e-02 0.50700 -0.303000 -0.407000 6.93e-02 1.47e-02
NCAM1 interactions 21 5.17e-04 2.75e-03 0.50700 -0.487000 -0.142000 1.14e-04 2.60e-01
Effects of PIP2 hydrolysis 19 1.91e-03 8.40e-03 0.50600 -0.324000 -0.388000 1.44e-02 3.39e-03
RNA Polymerase II Transcription Termination 57 6.73e-09 1.60e-07 0.50500 0.408000 0.298000 1.02e-07 9.96e-05
MET activates RAP1 and RAC1 10 2.20e-02 6.10e-02 0.50500 0.045700 0.503000 8.03e-01 5.87e-03
Infection with Mycobacterium tuberculosis 19 1.73e-03 7.74e-03 0.50400 0.255000 0.435000 5.49e-02 1.02e-03
N-Glycan antennae elongation 12 4.69e-03 1.77e-02 0.50200 -0.261000 0.429000 1.18e-01 1.00e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1 14 2.19e-03 9.33e-03 0.50200 -0.455000 0.212000 3.23e-03 1.70e-01
The NLRP3 inflammasome 10 1.75e-02 5.15e-02 0.49800 -0.089300 0.490000 6.25e-01 7.33e-03
Inflammasomes 12 5.69e-03 2.08e-02 0.49700 -0.219000 0.446000 1.90e-01 7.47e-03
Abortive elongation of HIV-1 transcript in the absence of Tat 21 1.21e-03 5.82e-03 0.49600 0.285000 0.406000 2.36e-02 1.28e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins 10 1.48e-02 4.57e-02 0.49300 -0.202000 0.449000 2.69e-01 1.39e-02
Smooth Muscle Contraction 32 2.37e-06 2.52e-05 0.49200 -0.474000 0.133000 3.58e-06 1.94e-01
HIV elongation arrest and recovery 27 2.35e-04 1.36e-03 0.49100 0.334000 0.360000 2.64e-03 1.22e-03
Pausing and recovery of HIV elongation 27 2.35e-04 1.36e-03 0.49100 0.334000 0.360000 2.64e-03 1.22e-03
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 10 3.33e-02 8.04e-02 0.48900 0.114000 0.475000 5.31e-01 9.29e-03
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 10 3.56e-02 8.42e-02 0.48800 -0.141000 -0.468000 4.41e-01 1.05e-02
GPVI-mediated activation cascade 18 2.68e-03 1.11e-02 0.48800 0.159000 0.461000 2.42e-01 7.09e-04
FGFR2 alternative splicing 22 1.17e-03 5.68e-03 0.48700 0.391000 0.290000 1.51e-03 1.84e-02
tRNA processing in the nucleus 48 2.34e-07 3.24e-06 0.48600 0.445000 0.195000 1.00e-07 1.93e-02
mRNA Splicing - Minor Pathway 47 6.18e-07 7.69e-06 0.48400 0.398000 0.275000 2.33e-06 1.11e-03
Nuclear Pore Complex (NPC) Disassembly 27 2.93e-04 1.67e-03 0.47500 0.427000 0.207000 1.24e-04 6.27e-02
Unwinding of DNA 10 2.86e-02 7.40e-02 0.47400 -0.035100 0.473000 8.47e-01 9.62e-03
AKT phosphorylates targets in the nucleus 10 5.45e-02 1.13e-01 0.47400 -0.381000 -0.282000 3.70e-02 1.23e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 12 1.98e-02 5.68e-02 0.47400 -0.467000 -0.079700 5.11e-03 6.33e-01
Peptide chain elongation 53 5.61e-09 1.38e-07 0.47200 -0.068600 0.467000 3.88e-01 4.29e-09
NGF-stimulated transcription 32 1.29e-05 1.11e-04 0.47000 -0.050900 0.467000 6.19e-01 4.91e-06
The citric acid (TCA) cycle and respiratory electron transport 142 1.02e-18 1.26e-16 0.46800 -0.202000 -0.423000 3.49e-05 3.92e-18
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 6.16e-02 1.24e-01 0.46600 0.337000 0.321000 6.49e-02 7.84e-02
rRNA processing 154 3.77e-19 5.17e-17 0.46500 0.338000 0.319000 4.82e-13 8.91e-12
p75NTR signals via NF-kB 13 1.33e-02 4.16e-02 0.46500 0.001700 0.465000 9.92e-01 3.72e-03
A tetrasaccharide linker sequence is required for GAG synthesis 18 1.16e-03 5.68e-03 0.46300 -0.413000 0.210000 2.41e-03 1.24e-01
SRP-dependent cotranslational protein targeting to membrane 74 1.60e-10 5.47e-09 0.46200 0.096800 0.451000 1.51e-01 1.96e-11
Response of EIF2AK4 (GCN2) to amino acid deficiency 63 6.94e-10 1.94e-08 0.46200 -0.031200 0.461000 6.69e-01 2.66e-10
Formation of RNA Pol II elongation complex 50 1.13e-06 1.31e-05 0.46000 0.371000 0.273000 5.81e-06 8.58e-04
RNA Polymerase II Transcription Elongation 50 1.13e-06 1.31e-05 0.46000 0.371000 0.273000 5.81e-06 8.58e-04
Formation of the cornified envelope 10 2.70e-02 7.07e-02 0.45900 -0.427000 0.168000 1.95e-02 3.58e-01
Selenocysteine synthesis 56 9.29e-09 2.08e-07 0.45900 -0.030100 0.458000 6.97e-01 3.24e-09
Transcriptional regulation by small RNAs 39 1.90e-05 1.58e-04 0.45800 0.406000 0.214000 1.19e-05 2.11e-02
Late Phase of HIV Life Cycle 112 8.01e-14 5.20e-12 0.45800 0.359000 0.285000 5.75e-11 1.98e-07
Defects in cobalamin (B12) metabolism 10 2.91e-02 7.42e-02 0.45700 0.138000 -0.436000 4.49e-01 1.70e-02
Unblocking of NMDA receptors, glutamate binding and activation 10 5.29e-02 1.10e-01 0.45700 -0.440000 -0.124000 1.60e-02 4.99e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 2.07e-02 5.90e-02 0.45500 0.149000 -0.430000 3.92e-01 1.36e-02
Leading Strand Synthesis 14 2.28e-02 6.21e-02 0.45300 0.227000 0.392000 1.41e-01 1.12e-02
Polymerase switching 14 2.28e-02 6.21e-02 0.45300 0.227000 0.392000 1.41e-01 1.12e-02
Viral mRNA Translation 53 3.28e-08 6.62e-07 0.45100 -0.055000 0.447000 4.89e-01 1.78e-08
PERK regulates gene expression 28 6.61e-04 3.47e-03 0.45000 0.355000 0.277000 1.14e-03 1.14e-02
Eukaryotic Translation Elongation 56 9.22e-09 2.08e-07 0.44900 -0.088300 0.441000 2.54e-01 1.20e-08
PKA activation 15 1.32e-02 4.15e-02 0.44800 -0.439000 -0.090000 3.28e-03 5.47e-01
Mitotic Telophase/Cytokinesis 10 3.02e-02 7.53e-02 0.44700 0.398000 -0.204000 2.93e-02 2.64e-01
Glycogen metabolism 23 1.92e-03 8.41e-03 0.44700 -0.415000 -0.167000 5.81e-04 1.65e-01
HIV Life Cycle 122 2.92e-14 2.12e-12 0.44700 0.349000 0.279000 2.98e-11 1.14e-07
Complex I biogenesis 52 1.03e-06 1.23e-05 0.44600 -0.196000 -0.400000 1.45e-02 6.02e-07
CLEC7A (Dectin-1) induces NFAT activation 10 7.81e-02 1.48e-01 0.44500 -0.330000 -0.299000 7.09e-02 1.01e-01
tRNA Aminoacylation 24 2.65e-04 1.52e-03 0.44500 0.184000 -0.405000 1.18e-01 5.99e-04
Metabolism of RNA 567 1.18e-61 1.46e-58 0.44500 0.370000 0.247000 2.72e-50 2.90e-23
Triglyceride catabolism 13 3.73e-02 8.65e-02 0.44300 -0.275000 -0.347000 8.66e-02 3.01e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 57 3.41e-08 6.78e-07 0.44000 -0.018700 0.440000 8.08e-01 9.70e-09
Influenza Infection 107 7.65e-13 4.10e-11 0.44000 0.169000 0.406000 2.56e-03 4.47e-13
Nuclear Receptor transcription pathway 38 7.86e-05 5.39e-04 0.43900 -0.353000 -0.261000 1.70e-04 5.45e-03
RHO GTPases Activate WASPs and WAVEs 31 2.07e-04 1.27e-03 0.43700 0.090300 0.427000 3.85e-01 3.88e-05
Regulation of HSF1-mediated heat shock response 65 1.13e-07 1.81e-06 0.43600 0.361000 0.244000 4.99e-07 6.87e-04
Negative epigenetic regulation of rRNA expression 43 1.94e-05 1.60e-04 0.43500 0.388000 0.197000 1.06e-05 2.58e-02
HS-GAG degradation 16 9.83e-03 3.28e-02 0.43500 -0.435000 -0.013800 2.59e-03 9.24e-01
Eukaryotic Translation Termination 55 6.49e-08 1.14e-06 0.43500 -0.048000 0.432000 5.39e-01 3.08e-08
Platelet calcium homeostasis 18 1.08e-02 3.55e-02 0.43400 -0.389000 -0.192000 4.26e-03 1.58e-01
RNA polymerase II transcribes snRNA genes 67 5.38e-08 1.00e-06 0.43400 0.386000 0.198000 4.77e-08 5.14e-03
Potassium Channels 34 2.77e-04 1.58e-03 0.43300 -0.334000 -0.275000 7.53e-04 5.54e-03
Sema3A PAK dependent Axon repulsion 15 7.59e-03 2.61e-02 0.43300 -0.183000 0.392000 2.20e-01 8.60e-03
mRNA Capping 26 1.84e-03 8.17e-03 0.42900 0.370000 0.218000 1.11e-03 5.41e-02
RNA Pol II CTD phosphorylation and interaction with CE 24 3.04e-03 1.23e-02 0.42700 0.376000 0.201000 1.42e-03 8.87e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 24 3.04e-03 1.23e-02 0.42700 0.376000 0.201000 1.42e-03 8.87e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 36 2.28e-04 1.35e-03 0.42600 0.307000 0.296000 1.45e-03 2.14e-03
HIV Transcription Elongation 36 2.28e-04 1.35e-03 0.42600 0.307000 0.296000 1.45e-03 2.14e-03
Tat-mediated elongation of the HIV-1 transcript 36 2.28e-04 1.35e-03 0.42600 0.307000 0.296000 1.45e-03 2.14e-03
CRMPs in Sema3A signaling 13 1.55e-02 4.72e-02 0.42300 -0.253000 0.339000 1.14e-01 3.41e-02
Interleukin-4 and Interleukin-13 signaling 64 4.62e-09 1.16e-07 0.42200 -0.130000 0.401000 7.24e-02 2.96e-08
Formation of a pool of free 40S subunits 63 4.28e-08 8.12e-07 0.42200 0.016800 0.421000 8.18e-01 7.58e-09
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 15 2.99e-02 7.51e-02 0.42100 0.368000 0.204000 1.37e-02 1.71e-01
Influenza Viral RNA Transcription and Replication 91 3.68e-10 1.08e-08 0.42000 0.157000 0.389000 9.98e-03 1.44e-10
Formation of HIV elongation complex in the absence of HIV Tat 38 1.84e-04 1.14e-03 0.41900 0.331000 0.257000 4.16e-04 6.22e-03
MET activates PTK2 signaling 15 1.65e-02 4.96e-02 0.41900 -0.419000 0.014700 5.02e-03 9.22e-01
Zinc transporters 11 8.45e-02 1.57e-01 0.41800 0.304000 0.287000 8.12e-02 9.89e-02
Condensation of Prophase Chromosomes 11 7.74e-02 1.47e-01 0.41800 0.373000 0.188000 3.24e-02 2.80e-01
Synthesis of IP3 and IP4 in the cytosol 19 6.94e-03 2.44e-02 0.41700 -0.416000 -0.028500 1.70e-03 8.30e-01
Peroxisomal lipid metabolism 22 4.38e-03 1.69e-02 0.41600 -0.095500 -0.405000 4.39e-01 1.01e-03
Selenoamino acid metabolism 68 1.24e-08 2.65e-07 0.41500 -0.013500 0.415000 8.48e-01 3.35e-09
Caspase activation via Death Receptors in the presence of ligand 11 3.42e-02 8.21e-02 0.41500 -0.239000 0.339000 1.70e-01 5.18e-02
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 20 9.88e-03 3.28e-02 0.41400 -0.168000 -0.378000 1.93e-01 3.45e-03
Integrin signaling 20 3.90e-03 1.53e-02 0.41200 -0.074700 0.405000 5.63e-01 1.71e-03
Glycogen storage diseases 11 6.51e-02 1.28e-01 0.41200 -0.407000 -0.060900 1.94e-02 7.27e-01
NoRC negatively regulates rRNA expression 40 1.23e-04 8.11e-04 0.41100 0.366000 0.187000 6.13e-05 4.10e-02
Processing of Capped Intronless Pre-mRNA 25 4.37e-03 1.69e-02 0.41100 0.264000 0.315000 2.26e-02 6.36e-03
TNFR1-induced proapoptotic signaling 11 3.62e-02 8.50e-02 0.41000 -0.322000 0.254000 6.44e-02 1.45e-01
B-WICH complex positively regulates rRNA expression 28 2.18e-03 9.33e-03 0.41000 0.226000 0.342000 3.83e-02 1.76e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 57 3.67e-06 3.71e-05 0.40900 0.353000 0.206000 4.05e-06 7.19e-03
Amplification of signal from the kinetochores 57 3.67e-06 3.71e-05 0.40900 0.353000 0.206000 4.05e-06 7.19e-03
Sealing of the nuclear envelope (NE) by ESCRT-III 20 2.52e-03 1.05e-02 0.40800 -0.279000 0.297000 3.06e-02 2.14e-02
Synthesis of bile acids and bile salts 18 1.43e-02 4.45e-02 0.40800 -0.099000 -0.395000 4.67e-01 3.69e-03
Respiratory electron transport 92 1.45e-09 3.89e-08 0.40800 -0.178000 -0.367000 3.30e-03 1.26e-09
SUMOylation of transcription factors 14 4.03e-02 9.23e-02 0.40700 0.134000 0.385000 3.86e-01 1.27e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 73 2.64e-08 5.42e-07 0.40700 0.076100 0.400000 2.62e-01 3.50e-09
NF-kB is activated and signals survival 10 6.02e-02 1.21e-01 0.40500 -0.142000 0.380000 4.38e-01 3.76e-02
Sema4D in semaphorin signaling 23 1.17e-03 5.68e-03 0.40500 -0.246000 0.322000 4.10e-02 7.59e-03
Metabolism of steroid hormones 12 3.67e-02 8.55e-02 0.40400 -0.117000 0.387000 4.84e-01 2.02e-02
BBSome-mediated cargo-targeting to cilium 18 1.30e-02 4.12e-02 0.40400 0.401000 0.049700 3.25e-03 7.15e-01
PKA activation in glucagon signalling 14 3.68e-02 8.57e-02 0.40300 -0.397000 -0.070800 1.02e-02 6.47e-01
Pre-NOTCH Processing in Golgi 14 2.52e-02 6.68e-02 0.40300 -0.398000 0.062000 9.92e-03 6.88e-01
Keratinization 12 3.23e-02 7.85e-02 0.40200 -0.345000 0.207000 3.86e-02 2.15e-01
L13a-mediated translational silencing of Ceruloplasmin expression 71 5.70e-08 1.02e-06 0.40100 0.059200 0.397000 3.90e-01 7.70e-09
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 96 1.52e-09 3.99e-08 0.39900 -0.176000 -0.358000 2.89e-03 1.44e-09
Negative regulation of MET activity 16 3.48e-02 8.29e-02 0.39700 0.182000 0.353000 2.09e-01 1.45e-02
PRC2 methylates histones and DNA 14 5.98e-02 1.21e-01 0.39500 0.258000 0.299000 9.44e-02 5.24e-02
Resolution of Sister Chromatid Cohesion 66 9.30e-07 1.14e-05 0.39500 0.362000 0.157000 3.63e-07 2.74e-02
Formation of the ternary complex, and subsequently, the 43S complex 38 2.25e-04 1.35e-03 0.39500 0.096900 0.383000 3.02e-01 4.45e-05
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 11 5.11e-02 1.08e-01 0.39500 -0.360000 0.162000 3.86e-02 3.54e-01
Defective EXT2 causes exostoses 2 11 5.11e-02 1.08e-01 0.39500 -0.360000 0.162000 3.86e-02 3.54e-01
Formation of the Early Elongation Complex 30 2.51e-03 1.05e-02 0.39400 0.299000 0.257000 4.65e-03 1.48e-02
Formation of the HIV-1 Early Elongation Complex 30 2.51e-03 1.05e-02 0.39400 0.299000 0.257000 4.65e-03 1.48e-02
Processing of Intronless Pre-mRNAs 17 3.26e-02 7.90e-02 0.39300 0.223000 0.324000 1.12e-01 2.06e-02
p75NTR recruits signalling complexes 10 1.15e-01 2.00e-01 0.39300 0.111000 0.377000 5.42e-01 3.91e-02
FGFR2 mutant receptor activation 18 2.41e-02 6.50e-02 0.39200 0.165000 0.356000 2.25e-01 8.95e-03
Stimuli-sensing channels 43 2.20e-04 1.34e-03 0.39100 -0.270000 -0.283000 2.23e-03 1.33e-03
HCMV Early Events 50 3.16e-05 2.43e-04 0.39000 0.363000 0.144000 9.30e-06 7.80e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 17 3.53e-02 8.38e-02 0.39000 0.229000 0.315000 1.03e-01 2.44e-02
The role of Nef in HIV-1 replication and disease pathogenesis 19 8.35e-03 2.84e-02 0.38900 -0.096200 0.377000 4.68e-01 4.46e-03
Activation of ATR in response to replication stress 28 4.47e-03 1.72e-02 0.38700 0.305000 0.238000 5.22e-03 2.93e-02
G0 and Early G1 23 1.20e-02 3.91e-02 0.38700 0.285000 0.262000 1.82e-02 2.96e-02
Ribosomal scanning and start codon recognition 45 9.38e-05 6.32e-04 0.38600 0.125000 0.366000 1.47e-01 2.23e-05
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 10 1.41e-01 2.34e-01 0.38600 0.198000 0.331000 2.78e-01 6.98e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 10 1.41e-01 2.34e-01 0.38600 0.198000 0.331000 2.78e-01 6.98e-02
Assembly Of The HIV Virion 12 4.65e-02 1.03e-01 0.38500 -0.147000 0.356000 3.79e-01 3.27e-02
CaM pathway 27 2.76e-03 1.13e-02 0.38400 -0.381000 -0.044100 6.07e-04 6.92e-01
Calmodulin induced events 27 2.76e-03 1.13e-02 0.38400 -0.381000 -0.044100 6.07e-04 6.92e-01
EML4 and NUDC in mitotic spindle formation 61 9.56e-06 8.48e-05 0.38100 0.326000 0.197000 1.10e-05 8.01e-03
DNA strand elongation 30 2.70e-03 1.12e-02 0.38000 0.136000 0.355000 1.98e-01 7.81e-04
PKA-mediated phosphorylation of CREB 17 2.92e-02 7.42e-02 0.37900 -0.372000 -0.072200 7.86e-03 6.06e-01
Inwardly rectifying K+ channels 17 4.20e-02 9.52e-02 0.37800 -0.212000 -0.314000 1.31e-01 2.51e-02
Activation of the pre-replicative complex 27 7.05e-03 2.47e-02 0.37800 0.273000 0.261000 1.40e-02 1.88e-02
PECAM1 interactions 10 7.67e-02 1.46e-01 0.37800 -0.250000 0.283000 1.70e-01 1.21e-01
Transcriptional activation of mitochondrial biogenesis 47 5.05e-05 3.69e-04 0.37800 -0.045300 -0.375000 5.91e-01 8.86e-06
FCGR3A-mediated phagocytosis 47 3.18e-05 2.43e-04 0.37700 -0.012200 0.376000 8.86e-01 8.17e-06
Leishmania phagocytosis 47 3.18e-05 2.43e-04 0.37700 -0.012200 0.376000 8.86e-01 8.17e-06
Parasite infection 47 3.18e-05 2.43e-04 0.37700 -0.012200 0.376000 8.86e-01 8.17e-06
Telomere Maintenance 56 3.82e-05 2.86e-04 0.37600 0.293000 0.235000 1.51e-04 2.34e-03
DAG and IP3 signaling 33 1.65e-03 7.53e-03 0.37500 -0.354000 -0.125000 4.36e-04 2.15e-01
Cap-dependent Translation Initiation 79 1.07e-07 1.74e-06 0.37500 0.068100 0.369000 2.96e-01 1.48e-08
Eukaryotic Translation Initiation 79 1.07e-07 1.74e-06 0.37500 0.068100 0.369000 2.96e-01 1.48e-08
RORA activates gene expression 17 3.50e-02 8.31e-02 0.37500 -0.106000 -0.360000 4.50e-01 1.02e-02
ATF4 activates genes in response to endoplasmic reticulum stress 24 1.28e-02 4.05e-02 0.37500 0.296000 0.230000 1.20e-02 5.11e-02
Listeria monocytogenes entry into host cells 15 5.94e-02 1.21e-01 0.37500 0.162000 0.338000 2.78e-01 2.35e-02
Translation initiation complex formation 44 1.96e-04 1.21e-03 0.37500 0.119000 0.355000 1.74e-01 4.61e-05
Ephrin signaling 18 1.16e-02 3.81e-02 0.37400 -0.192000 0.321000 1.58e-01 1.83e-02
Fatty acid metabolism 102 1.05e-08 2.26e-07 0.37400 -0.222000 -0.301000 1.08e-04 1.57e-07
Regulation of actin dynamics for phagocytic cup formation 49 2.16e-05 1.73e-04 0.37400 -0.022700 0.373000 7.84e-01 6.29e-06
IKK complex recruitment mediated by RIP1 14 6.82e-02 1.33e-01 0.37400 0.130000 0.350000 4.00e-01 2.32e-02
TP53 Regulates Transcription of DNA Repair Genes 51 8.90e-05 6.03e-04 0.37300 0.322000 0.188000 6.89e-05 2.05e-02
Chromosome Maintenance 68 5.02e-06 4.81e-05 0.37300 0.301000 0.221000 1.85e-05 1.67e-03
Translesion Synthesis by POLH 16 4.84e-02 1.05e-01 0.37200 0.347000 0.136000 1.64e-02 3.45e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 6.02e-02 1.21e-01 0.37200 0.068200 0.366000 6.59e-01 1.78e-02
Processing of DNA double-strand break ends 50 1.40e-04 8.93e-04 0.37100 0.295000 0.226000 3.18e-04 5.80e-03
Mitochondrial biogenesis 66 2.33e-06 2.50e-05 0.37000 -0.071200 -0.363000 3.18e-01 3.57e-07
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 28 6.33e-03 2.28e-02 0.36900 0.173000 0.326000 1.13e-01 2.83e-03
Deposition of new CENPA-containing nucleosomes at the centromere 14 8.30e-02 1.55e-01 0.36900 0.308000 0.203000 4.58e-02 1.88e-01
Nucleosome assembly 14 8.30e-02 1.55e-01 0.36900 0.308000 0.203000 4.58e-02 1.88e-01
rRNA processing in the mitochondrion 11 1.08e-01 1.91e-01 0.36900 -0.037300 -0.367000 8.30e-01 3.51e-02
RIP-mediated NFkB activation via ZBP1 14 6.49e-02 1.28e-01 0.36900 0.076300 0.361000 6.21e-01 1.95e-02
Lagging Strand Synthesis 20 2.99e-02 7.51e-02 0.36800 0.221000 0.295000 8.72e-02 2.26e-02
Synthesis of PIPs at the Golgi membrane 15 6.71e-02 1.31e-01 0.36800 0.326000 0.170000 2.88e-02 2.53e-01
NCAM signaling for neurite out-growth 38 7.92e-04 4.12e-03 0.36800 -0.350000 -0.112000 1.88e-04 2.31e-01
SUMOylation of chromatin organization proteins 46 2.49e-04 1.43e-03 0.36700 0.333000 0.155000 9.66e-05 6.95e-02
p38MAPK events 12 8.57e-02 1.58e-01 0.36600 -0.366000 -0.006550 2.84e-02 9.69e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 45 2.48e-04 1.43e-03 0.36500 0.113000 0.347000 1.91e-01 5.73e-05
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 75 6.05e-07 7.69e-06 0.36400 0.065700 0.358000 3.26e-01 8.76e-08
Nonsense-Mediated Decay (NMD) 75 6.05e-07 7.69e-06 0.36400 0.065700 0.358000 3.26e-01 8.76e-08
Activation of Matrix Metalloproteinases 11 7.71e-02 1.47e-01 0.36200 -0.307000 0.193000 7.79e-02 2.69e-01
Antiviral mechanism by IFN-stimulated genes 64 2.08e-05 1.69e-04 0.36200 0.282000 0.227000 9.80e-05 1.69e-03
Diseases associated with the TLR signaling cascade 16 2.50e-02 6.67e-02 0.36200 -0.174000 0.317000 2.28e-01 2.80e-02
Diseases of Immune System 16 2.50e-02 6.67e-02 0.36200 -0.174000 0.317000 2.28e-01 2.80e-02
N-glycan antennae elongation in the medial/trans-Golgi 17 2.28e-02 6.21e-02 0.36100 -0.124000 0.339000 3.76e-01 1.56e-02
tRNA processing 98 1.89e-08 3.94e-07 0.36100 0.347000 0.100000 3.23e-09 8.80e-02
Neurexins and neuroligins 26 3.37e-03 1.35e-02 0.36100 -0.105000 0.345000 3.54e-01 2.34e-03
Syndecan interactions 17 2.88e-02 7.40e-02 0.36000 -0.048400 0.357000 7.30e-01 1.09e-02
HIV Infection 187 5.00e-14 3.43e-12 0.36000 0.243000 0.265000 1.09e-08 4.99e-10
Chondroitin sulfate biosynthesis 14 4.32e-02 9.75e-02 0.35900 -0.155000 0.324000 3.14e-01 3.62e-02
InlB-mediated entry of Listeria monocytogenes into host cell 11 1.49e-01 2.43e-01 0.35900 0.151000 0.325000 3.85e-01 6.18e-02
Regulation of TP53 Activity through Methylation 14 5.22e-02 1.09e-01 0.35700 0.349000 -0.078500 2.39e-02 6.11e-01
Constitutive Signaling by Overexpressed ERBB2 10 1.65e-01 2.65e-01 0.35700 0.092200 0.345000 6.14e-01 5.87e-02
Gene Silencing by RNA 54 4.50e-05 3.30e-04 0.35700 0.352000 0.058800 7.67e-06 4.55e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 25 1.59e-02 4.83e-02 0.35700 0.294000 0.203000 1.10e-02 7.93e-02
tRNA modification in the nucleus and cytosol 38 1.57e-03 7.23e-03 0.35600 0.322000 0.152000 5.97e-04 1.05e-01
Signaling by Leptin 10 1.83e-01 2.87e-01 0.35600 -0.320000 -0.157000 8.02e-02 3.90e-01
KSRP (KHSRP) binds and destabilizes mRNA 16 6.76e-02 1.32e-01 0.35600 0.316000 0.164000 2.87e-02 2.57e-01
RNA Polymerase I Promoter Escape 25 1.67e-02 5.01e-02 0.35500 0.292000 0.202000 1.15e-02 8.10e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 15 3.95e-02 9.10e-02 0.35500 -0.125000 0.332000 4.03e-01 2.60e-02
HS-GAG biosynthesis 18 1.77e-02 5.20e-02 0.35500 -0.292000 0.201000 3.18e-02 1.40e-01
Nuclear Envelope (NE) Reassembly 59 5.73e-05 4.11e-04 0.35500 0.173000 0.309000 2.15e-02 4.04e-05
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 1.44e-01 2.38e-01 0.35400 0.220000 0.278000 1.88e-01 9.59e-02
Interleukin-37 signaling 16 4.96e-02 1.07e-01 0.35400 0.027200 0.353000 8.51e-01 1.47e-02
PIWI-interacting RNA (piRNA) biogenesis 13 1.24e-01 2.14e-01 0.35300 0.246000 0.254000 1.25e-01 1.13e-01
Polymerase switching on the C-strand of the telomere 22 2.96e-02 7.47e-02 0.35300 0.252000 0.248000 4.11e-02 4.42e-02
Platelet Aggregation (Plug Formation) 22 9.26e-03 3.11e-02 0.35300 -0.121000 0.332000 3.26e-01 7.08e-03
Synaptic adhesion-like molecules 12 1.18e-01 2.06e-01 0.35300 -0.344000 -0.078300 3.92e-02 6.39e-01
Sema4D induced cell migration and growth-cone collapse 19 1.48e-02 4.57e-02 0.35200 -0.206000 0.286000 1.20e-01 3.11e-02
Extension of Telomeres 43 1.02e-03 5.10e-03 0.35200 0.281000 0.212000 1.43e-03 1.63e-02
Mitochondrial translation 87 7.14e-09 1.66e-07 0.35200 0.158000 -0.314000 1.08e-02 4.14e-07
Cell-extracellular matrix interactions 16 2.86e-02 7.40e-02 0.35200 -0.258000 0.238000 7.37e-02 9.88e-02
Caspase-mediated cleavage of cytoskeletal proteins 11 8.75e-02 1.61e-01 0.35100 -0.257000 0.238000 1.39e-01 1.71e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) 33 5.46e-03 2.02e-02 0.35000 0.222000 0.271000 2.71e-02 7.17e-03
Interferon alpha/beta signaling 36 1.06e-03 5.26e-03 0.35000 -0.008140 0.350000 9.33e-01 2.80e-04
SUMOylation of DNA damage response and repair proteins 62 3.80e-05 2.86e-04 0.35000 0.318000 0.146000 1.51e-05 4.76e-02
Pentose phosphate pathway 12 1.45e-01 2.39e-01 0.34900 0.167000 0.306000 3.16e-01 6.64e-02
Cell recruitment (pro-inflammatory response) 12 1.02e-01 1.82e-01 0.34800 -0.020900 0.347000 9.00e-01 3.74e-02
Purinergic signaling in leishmaniasis infection 12 1.02e-01 1.82e-01 0.34800 -0.020900 0.347000 9.00e-01 3.74e-02
RHO GTPases Activate Formins 80 4.18e-06 4.11e-05 0.34800 0.222000 0.267000 6.01e-04 3.69e-05
Inhibition of DNA recombination at telomere 19 5.04e-02 1.08e-01 0.34700 0.290000 0.192000 2.89e-02 1.48e-01
Activation of AMPK downstream of NMDARs 10 2.10e-01 3.20e-01 0.34700 -0.282000 -0.203000 1.23e-01 2.67e-01
Regulation of IFNA signaling 12 9.96e-02 1.79e-01 0.34700 -0.037800 0.345000 8.21e-01 3.86e-02
Laminin interactions 20 3.17e-02 7.78e-02 0.34700 -0.339000 -0.071600 8.67e-03 5.80e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 5.14e-02 1.09e-01 0.34600 0.191000 0.289000 1.50e-01 2.94e-02
Activation of G protein gated Potassium channels 14 1.14e-01 1.99e-01 0.34600 -0.201000 -0.281000 1.94e-01 6.84e-02
G protein gated Potassium channels 14 1.14e-01 1.99e-01 0.34600 -0.201000 -0.281000 1.94e-01 6.84e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 14 1.14e-01 1.99e-01 0.34600 -0.201000 -0.281000 1.94e-01 6.84e-02
ISG15 antiviral mechanism 59 1.25e-04 8.19e-04 0.34400 0.271000 0.213000 3.29e-04 4.79e-03
Epigenetic regulation of gene expression 79 5.97e-06 5.53e-05 0.34400 0.279000 0.201000 1.92e-05 2.03e-03
PCNA-Dependent Long Patch Base Excision Repair 21 3.97e-02 9.11e-02 0.34300 0.189000 0.287000 1.34e-01 2.31e-02
Collagen biosynthesis and modifying enzymes 48 7.75e-05 5.36e-04 0.34300 -0.330000 0.095600 7.91e-05 2.53e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 13 1.21e-01 2.09e-01 0.34300 0.113000 0.324000 4.82e-01 4.32e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter 27 1.06e-02 3.52e-02 0.34300 0.335000 0.071600 2.60e-03 5.20e-01
Signalling to RAS 16 4.23e-02 9.57e-02 0.34300 -0.328000 0.100000 2.34e-02 4.88e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 48 4.29e-04 2.34e-03 0.34200 0.107000 0.324000 1.99e-01 1.02e-04
EPHA-mediated growth cone collapse 13 7.76e-02 1.47e-01 0.34100 -0.103000 0.325000 5.20e-01 4.24e-02
Basigin interactions 17 3.45e-02 8.24e-02 0.34000 -0.317000 0.123000 2.37e-02 3.81e-01
Peroxisomal protein import 49 4.34e-04 2.36e-03 0.33900 -0.117000 -0.319000 1.59e-01 1.14e-04
Telomere C-strand (Lagging Strand) Synthesis 30 1.20e-02 3.91e-02 0.33900 0.237000 0.242000 2.46e-02 2.17e-02
Mitochondrial calcium ion transport 21 2.57e-02 6.80e-02 0.33800 -0.011200 -0.338000 9.29e-01 7.33e-03
Nuclear Envelope Breakdown 42 1.65e-03 7.53e-03 0.33800 0.303000 0.151000 6.93e-04 9.09e-02
Bile acid and bile salt metabolism 20 4.37e-02 9.82e-02 0.33800 -0.116000 -0.317000 3.69e-01 1.42e-02
Regulation of KIT signaling 14 5.70e-02 1.17e-01 0.33700 -0.224000 0.252000 1.46e-01 1.03e-01
Mitochondrial translation elongation 81 1.07e-07 1.74e-06 0.33700 0.158000 -0.297000 1.39e-02 3.87e-06
Triglyceride metabolism 20 4.98e-02 1.07e-01 0.33700 -0.163000 -0.295000 2.07e-01 2.25e-02
Initiation of Nuclear Envelope (NE) Reformation 17 8.32e-02 1.55e-01 0.33600 0.196000 0.273000 1.62e-01 5.16e-02
Mucopolysaccharidoses 11 1.46e-01 2.40e-01 0.33600 -0.335000 0.008360 5.41e-02 9.62e-01
RHO GTPases activate PAKs 19 2.33e-02 6.34e-02 0.33500 -0.293000 0.163000 2.72e-02 2.18e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 5.95e-02 1.21e-01 0.33500 -0.216000 0.257000 1.63e-01 9.66e-02
Ca-dependent events 29 7.39e-03 2.57e-02 0.33500 -0.334000 -0.020600 1.84e-03 8.48e-01
MET promotes cell motility 25 6.48e-03 2.32e-02 0.33500 -0.247000 0.226000 3.25e-02 5.06e-02
Cellular response to heat stress 82 7.91e-06 7.22e-05 0.33500 0.231000 0.243000 3.15e-04 1.46e-04
IRE1alpha activates chaperones 47 3.37e-04 1.87e-03 0.33500 0.012300 0.335000 8.84e-01 7.36e-05
Host Interactions of HIV factors 102 3.58e-07 4.85e-06 0.33500 0.178000 0.283000 1.91e-03 8.14e-07
Telomere Extension By Telomerase 19 4.91e-02 1.06e-01 0.33300 0.325000 0.075600 1.43e-02 5.68e-01
Retinoid metabolism and transport 19 2.31e-02 6.29e-02 0.33300 -0.263000 0.205000 4.76e-02 1.23e-01
Beta-catenin phosphorylation cascade 15 1.19e-01 2.06e-01 0.33200 0.248000 0.222000 9.67e-02 1.37e-01
Degradation of the extracellular matrix 58 1.51e-05 1.27e-04 0.33200 -0.301000 0.141000 7.56e-05 6.32e-02
Mitochondrial translation termination 81 1.69e-07 2.43e-06 0.33200 0.156000 -0.293000 1.54e-02 5.28e-06
Frs2-mediated activation 10 2.28e-01 3.43e-01 0.33100 0.138000 0.301000 4.49e-01 9.93e-02
Mitotic Spindle Checkpoint 74 1.96e-05 1.60e-04 0.33000 0.302000 0.134000 7.42e-06 4.60e-02
Regulation of MECP2 expression and activity 26 1.82e-02 5.29e-02 0.32900 -0.078400 -0.320000 4.89e-01 4.77e-03
Cell surface interactions at the vascular wall 72 1.01e-06 1.22e-05 0.32800 -0.264000 0.195000 1.11e-04 4.20e-03
ATF6 (ATF6-alpha) activates chaperones 12 1.68e-01 2.69e-01 0.32800 0.106000 0.310000 5.23e-01 6.32e-02
Mitochondrial translation initiation 81 2.64e-07 3.61e-06 0.32800 0.152000 -0.290000 1.86e-02 6.47e-06
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 3.64e-02 8.51e-02 0.32700 0.206000 0.254000 8.08e-02 3.10e-02
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 26 1.70e-02 5.07e-02 0.32600 0.044500 0.323000 6.95e-01 4.34e-03
RHO GTPases activate CIT 17 4.20e-02 9.52e-02 0.32600 -0.151000 0.289000 2.80e-01 3.92e-02
DNA Damage/Telomere Stress Induced Senescence 26 2.97e-02 7.48e-02 0.32500 0.225000 0.234000 4.72e-02 3.88e-02
Transport of inorganic cations/anions and amino acids/oligopeptides 56 2.32e-04 1.36e-03 0.32500 -0.315000 -0.077500 4.54e-05 3.17e-01
Metabolism of porphyrins 18 8.01e-02 1.51e-01 0.32400 -0.143000 -0.291000 2.93e-01 3.29e-02
Heparan sulfate/heparin (HS-GAG) metabolism 34 1.85e-03 8.23e-03 0.32300 -0.273000 0.173000 5.94e-03 8.07e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 1.27e-01 2.17e-01 0.32300 0.008550 0.322000 9.57e-01 4.42e-02
EPHB-mediated forward signaling 32 6.66e-03 2.37e-02 0.32200 0.019700 0.322000 8.47e-01 1.64e-03
Mitotic Prophase 70 7.75e-05 5.36e-04 0.32200 0.273000 0.171000 7.92e-05 1.37e-02
Recognition of DNA damage by PCNA-containing replication complex 28 2.39e-02 6.45e-02 0.32200 0.252000 0.200000 2.12e-02 6.66e-02
Translesion synthesis by POLI 15 1.14e-01 1.99e-01 0.32100 0.309000 0.089100 3.84e-02 5.50e-01
ZBP1(DAI) mediated induction of type I IFNs 17 8.66e-02 1.60e-01 0.32100 0.094900 0.307000 4.99e-01 2.86e-02
Nucleotide salvage 18 4.48e-02 9.99e-02 0.32000 -0.307000 0.090700 2.40e-02 5.05e-01
Deadenylation of mRNA 24 2.71e-02 7.09e-02 0.32000 0.317000 0.047400 7.24e-03 6.88e-01
RNA Polymerase III Chain Elongation 17 9.28e-02 1.69e-01 0.32000 0.297000 0.119000 3.38e-02 3.98e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 1.84e-01 2.87e-01 0.32000 -0.312000 0.071400 8.75e-02 6.96e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 9.29e-04 4.72e-03 0.32000 -0.242000 0.210000 1.00e-02 2.52e-02
Meiotic recombination 17 7.02e-02 1.36e-01 0.32000 0.320000 0.009430 2.25e-02 9.46e-01
XBP1(S) activates chaperone genes 45 8.77e-04 4.49e-03 0.31800 -0.003590 0.318000 9.67e-01 2.23e-04
Diseases associated with glycosaminoglycan metabolism 31 3.60e-03 1.42e-02 0.31800 -0.236000 0.213000 2.31e-02 4.00e-02
Translesion synthesis by POLK 15 9.74e-02 1.76e-01 0.31800 0.318000 0.003740 3.30e-02 9.80e-01
Unfolded Protein Response (UPR) 82 1.52e-05 1.27e-04 0.31700 0.127000 0.291000 4.74e-02 5.52e-06
Calnexin/calreticulin cycle 23 4.42e-02 9.91e-02 0.31600 0.124000 0.291000 3.02e-01 1.57e-02
Interleukin-20 family signaling 12 1.59e-01 2.57e-01 0.31500 -0.315000 0.003040 5.90e-02 9.85e-01
RHO GTPases Activate ROCKs 18 4.12e-02 9.36e-02 0.31500 -0.194000 0.248000 1.54e-01 6.91e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 18 6.31e-02 1.26e-01 0.31500 -0.006640 0.314000 9.61e-01 2.09e-02
HSF1 activation 22 6.08e-02 1.22e-01 0.31300 0.179000 0.257000 1.47e-01 3.69e-02
Class I peroxisomal membrane protein import 20 4.36e-02 9.82e-02 0.31200 0.040200 -0.310000 7.56e-01 1.65e-02
Caspase activation via extrinsic apoptotic signalling pathway 20 3.13e-02 7.74e-02 0.31200 -0.255000 0.179000 4.83e-02 1.66e-01
Amino acid transport across the plasma membrane 20 4.07e-02 9.28e-02 0.31100 -0.303000 0.071400 1.91e-02 5.81e-01
CS/DS degradation 10 1.80e-01 2.83e-01 0.31100 -0.265000 0.163000 1.47e-01 3.72e-01
SCF(Skp2)-mediated degradation of p27/p21 52 1.03e-03 5.10e-03 0.31100 0.106000 0.292000 1.87e-01 2.73e-04
Nephrin family interactions 17 1.12e-01 1.97e-01 0.31000 0.137000 0.279000 3.30e-01 4.66e-02
Semaphorin interactions 54 9.63e-05 6.46e-04 0.31000 -0.186000 0.248000 1.81e-02 1.65e-03
Positive epigenetic regulation of rRNA expression 41 5.65e-03 2.08e-02 0.30900 0.144000 0.273000 1.11e-01 2.51e-03
Removal of the Flap Intermediate 14 1.76e-01 2.78e-01 0.30800 0.167000 0.259000 2.79e-01 9.39e-02
Prolonged ERK activation events 12 2.32e-01 3.49e-01 0.30800 0.220000 0.216000 1.88e-01 1.96e-01
Processive synthesis on the lagging strand 15 1.46e-01 2.41e-01 0.30800 0.121000 0.283000 4.19e-01 5.80e-02
Amyloid fiber formation 29 7.55e-03 2.60e-02 0.30700 -0.185000 0.245000 8.54e-02 2.23e-02
Transcriptional regulation of granulopoiesis 23 3.45e-02 8.24e-02 0.30700 -0.007540 0.307000 9.50e-01 1.09e-02
Sulfur amino acid metabolism 21 7.84e-02 1.48e-01 0.30700 -0.196000 -0.236000 1.19e-01 6.15e-02
E2F mediated regulation of DNA replication 19 1.00e-01 1.80e-01 0.30600 0.240000 0.190000 6.97e-02 1.52e-01
Diseases of carbohydrate metabolism 26 2.92e-02 7.42e-02 0.30600 -0.301000 -0.055100 7.85e-03 6.27e-01
Processing of SMDT1 15 8.43e-02 1.57e-01 0.30600 0.149000 -0.267000 3.18e-01 7.30e-02
Acyl chain remodelling of PS 10 3.01e-01 4.17e-01 0.30600 0.217000 0.215000 2.34e-01 2.38e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.32e-01 2.24e-01 0.30500 -0.079400 0.295000 6.20e-01 6.56e-02
Regulation of signaling by CBL 13 1.65e-01 2.65e-01 0.30500 0.033600 0.304000 8.34e-01 5.81e-02
ECM proteoglycans 37 2.40e-03 1.01e-02 0.30500 -0.270000 0.143000 4.56e-03 1.33e-01
SUMOylation of intracellular receptors 23 6.26e-02 1.25e-01 0.30500 -0.247000 -0.178000 4.02e-02 1.39e-01
NRAGE signals death through JNK 43 3.04e-03 1.23e-02 0.30500 -0.300000 -0.050700 6.63e-04 5.66e-01
Translation of structural proteins 25 1.60e-02 4.85e-02 0.30400 -0.194000 0.234000 9.41e-02 4.30e-02
RNA Polymerase I Transcription Termination 25 5.04e-02 1.08e-01 0.30400 0.248000 0.176000 3.22e-02 1.29e-01
Early Phase of HIV Life Cycle 11 2.64e-01 3.82e-01 0.30300 0.149000 0.264000 3.93e-01 1.30e-01
Detoxification of Reactive Oxygen Species 26 1.85e-02 5.34e-02 0.30300 -0.291000 0.084000 1.04e-02 4.59e-01
Sialic acid metabolism 23 3.64e-02 8.51e-02 0.30200 -0.302000 0.021000 1.23e-02 8.62e-01
Spry regulation of FGF signaling 14 1.51e-01 2.45e-01 0.30000 0.024900 0.299000 8.72e-01 5.25e-02
Collagen formation 64 7.78e-05 5.36e-04 0.30000 -0.293000 0.065200 5.24e-05 3.67e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 2.21e-01 3.35e-01 0.30000 -0.300000 -0.008940 8.53e-02 9.59e-01
Erythropoietin activates RAS 11 2.33e-01 3.49e-01 0.29900 0.037000 0.297000 8.32e-01 8.80e-02
Protein-protein interactions at synapses 41 1.40e-03 6.57e-03 0.29900 -0.198000 0.224000 2.81e-02 1.33e-02
Activation of BAD and translocation to mitochondria 13 1.25e-01 2.15e-01 0.29800 -0.221000 0.200000 1.69e-01 2.11e-01
Other interleukin signaling 13 1.34e-01 2.25e-01 0.29800 -0.132000 0.267000 4.10e-01 9.57e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 11 1.75e-01 2.77e-01 0.29700 0.238000 -0.178000 1.71e-01 3.07e-01
G2/M Checkpoints 106 5.68e-06 5.31e-05 0.29700 0.171000 0.243000 2.38e-03 1.59e-05
Cristae formation 10 2.37e-01 3.54e-01 0.29700 0.050400 -0.293000 7.83e-01 1.09e-01
Translesion synthesis by REV1 14 1.69e-01 2.69e-01 0.29700 0.291000 0.061600 5.96e-02 6.90e-01
Chaperone Mediated Autophagy 14 1.33e-01 2.25e-01 0.29700 -0.055000 0.292000 7.22e-01 5.89e-02
Glutathione conjugation 21 8.87e-02 1.62e-01 0.29700 -0.253000 -0.155000 4.50e-02 2.18e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 25 5.22e-02 1.09e-01 0.29600 0.270000 0.123000 1.96e-02 2.89e-01
Cholesterol biosynthesis 23 3.23e-02 7.85e-02 0.29500 -0.275000 0.107000 2.24e-02 3.76e-01
FCGR3A-mediated IL10 synthesis 25 4.70e-02 1.03e-01 0.29400 -0.284000 -0.075900 1.39e-02 5.11e-01
Cell Cycle Checkpoints 191 8.03e-10 2.20e-08 0.29400 0.219000 0.197000 2.07e-07 2.98e-06
mRNA decay by 3' to 5' exoribonuclease 15 1.88e-01 2.92e-01 0.29400 0.232000 0.180000 1.20e-01 2.27e-01
Signaling by FGFR2 52 3.19e-03 1.29e-02 0.29400 0.200000 0.215000 1.26e-02 7.36e-03
GABA receptor activation 27 5.19e-02 1.09e-01 0.29200 -0.222000 -0.189000 4.57e-02 8.88e-02
Non-integrin membrane-ECM interactions 36 5.83e-03 2.12e-02 0.29200 -0.280000 0.083100 3.71e-03 3.89e-01
Regulation of expression of SLITs and ROBOs 114 5.73e-07 7.44e-06 0.29200 0.025900 0.290000 6.33e-01 9.05e-08
GAB1 signalosome 12 1.64e-01 2.65e-01 0.29100 -0.243000 0.160000 1.45e-01 3.38e-01
Intrinsic Pathway for Apoptosis 42 2.31e-03 9.78e-03 0.29000 -0.108000 0.269000 2.26e-01 2.53e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 4.91e-03 1.83e-02 0.29000 0.096700 0.273000 2.57e-01 1.35e-03
Signaling by Retinoic Acid 29 4.37e-02 9.82e-02 0.28900 -0.177000 -0.229000 1.00e-01 3.28e-02
Negative regulation of FGFR3 signaling 19 1.08e-01 1.91e-01 0.28900 0.079500 0.278000 5.49e-01 3.61e-02
Glucagon signaling in metabolic regulation 23 7.00e-02 1.36e-01 0.28900 -0.274000 -0.091700 2.30e-02 4.47e-01
Regulation of RUNX3 expression and activity 47 4.77e-03 1.79e-02 0.28900 0.104000 0.269000 2.20e-01 1.41e-03
Regulation of IFNG signaling 13 2.38e-01 3.54e-01 0.28800 0.136000 0.255000 3.98e-01 1.12e-01
Visual phototransduction 38 3.57e-03 1.41e-02 0.28800 -0.223000 0.182000 1.73e-02 5.28e-02
Metabolism of fat-soluble vitamins 22 3.88e-02 8.97e-02 0.28800 -0.235000 0.166000 5.64e-02 1.78e-01
Mitochondrial protein import 55 9.79e-04 4.91e-03 0.28800 -0.007820 -0.288000 9.20e-01 2.28e-04
Metal ion SLC transporters 17 1.44e-01 2.38e-01 0.28800 0.096100 0.271000 4.93e-01 5.31e-02
Association of TriC/CCT with target proteins during biosynthesis 36 2.21e-02 6.10e-02 0.28800 0.210000 0.196000 2.91e-02 4.19e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 75 3.17e-04 1.77e-03 0.28700 0.150000 0.245000 2.51e-02 2.54e-04
Myogenesis 26 4.77e-02 1.05e-01 0.28700 -0.279000 -0.066500 1.39e-02 5.57e-01
Orc1 removal from chromatin 59 1.45e-03 6.75e-03 0.28700 0.115000 0.263000 1.28e-01 4.88e-04
Plasma lipoprotein remodeling 11 2.69e-01 3.89e-01 0.28700 -0.282000 -0.051300 1.05e-01 7.68e-01
Extracellular matrix organization 194 1.08e-12 5.56e-11 0.28700 -0.253000 0.134000 1.41e-09 1.31e-03
RNA Polymerase III Transcription Initiation 34 2.09e-02 5.90e-02 0.28600 0.272000 0.089600 6.07e-03 3.66e-01
Regulation of TP53 Activity through Phosphorylation 74 3.52e-04 1.95e-03 0.28600 0.248000 0.144000 2.37e-04 3.25e-02
EPH-Ephrin signaling 75 3.33e-05 2.53e-04 0.28600 -0.083500 0.274000 2.12e-01 4.21e-05
DNA Replication Pre-Initiation 70 5.28e-04 2.79e-03 0.28600 0.139000 0.250000 4.40e-02 3.04e-04
Transcriptional Regulation by E2F6 29 3.87e-02 8.95e-02 0.28600 0.268000 0.101000 1.26e-02 3.47e-01
Platelet sensitization by LDL 13 2.39e-01 3.55e-01 0.28600 0.118000 0.260000 4.61e-01 1.04e-01
Sphingolipid de novo biosynthesis 32 2.25e-02 6.20e-02 0.28400 0.036100 0.281000 7.24e-01 5.92e-03
G2/M DNA damage checkpoint 49 6.42e-03 2.30e-02 0.28400 0.212000 0.188000 1.02e-02 2.29e-02
Elastic fibre formation 34 1.26e-02 4.04e-02 0.28200 -0.040700 0.279000 6.81e-01 4.83e-03
Class B/2 (Secretin family receptors) 33 3.25e-02 7.89e-02 0.28200 -0.236000 -0.155000 1.91e-02 1.23e-01
Synthesis of PIPs at the late endosome membrane 10 2.51e-01 3.68e-01 0.28200 0.257000 -0.116000 1.59e-01 5.27e-01
Scavenging by Class A Receptors 13 1.56e-01 2.53e-01 0.28200 -0.196000 0.203000 2.22e-01 2.05e-01
Separation of Sister Chromatids 125 2.42e-06 2.55e-05 0.28200 0.242000 0.145000 3.23e-06 5.19e-03
Assembly and cell surface presentation of NMDA receptors 13 2.16e-01 3.28e-01 0.28100 -0.280000 -0.027200 8.08e-02 8.65e-01
Interferon Signaling 120 4.20e-06 4.11e-05 0.28100 0.140000 0.244000 8.42e-03 4.19e-06
RAF-independent MAPK1/3 activation 21 5.24e-02 1.10e-01 0.28100 -0.157000 0.233000 2.13e-01 6.47e-02
Mitotic Anaphase 171 3.82e-08 7.37e-07 0.28100 0.203000 0.194000 4.97e-06 1.32e-05
Mitotic Metaphase and Anaphase 171 3.82e-08 7.37e-07 0.28100 0.203000 0.194000 4.97e-06 1.32e-05
Metabolism of cofactors 16 1.93e-01 2.98e-01 0.28100 -0.152000 -0.236000 2.94e-01 1.02e-01
Signaling by FGFR 60 2.35e-03 9.91e-03 0.28100 0.186000 0.210000 1.29e-02 4.88e-03
IL-6-type cytokine receptor ligand interactions 10 3.48e-01 4.64e-01 0.28100 -0.253000 -0.122000 1.67e-01 5.04e-01
Transcription of E2F targets under negative control by DREAM complex 17 1.76e-01 2.78e-01 0.28000 0.231000 0.159000 9.99e-02 2.55e-01
Dual incision in TC-NER 60 2.06e-03 8.94e-03 0.27800 0.249000 0.124000 8.46e-04 9.84e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 15 2.10e-01 3.20e-01 0.27700 0.254000 0.112000 8.85e-02 4.55e-01
Collagen chain trimerization 32 2.78e-02 7.23e-02 0.27600 -0.274000 -0.038500 7.45e-03 7.07e-01
Activation of GABAB receptors 25 8.72e-02 1.60e-01 0.27500 -0.213000 -0.174000 6.54e-02 1.31e-01
GABA B receptor activation 25 8.72e-02 1.60e-01 0.27500 -0.213000 -0.174000 6.54e-02 1.31e-01
HDMs demethylate histones 19 1.55e-01 2.52e-01 0.27500 0.160000 0.224000 2.27e-01 9.16e-02
Collagen degradation 20 9.32e-02 1.69e-01 0.27500 -0.275000 0.015000 3.35e-02 9.07e-01
Formation of TC-NER Pre-Incision Complex 48 5.87e-03 2.13e-02 0.27500 0.267000 0.064000 1.39e-03 4.43e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 26 7.36e-02 1.42e-01 0.27400 0.246000 0.121000 3.00e-02 2.86e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 3.00e-01 4.16e-01 0.27300 0.041200 -0.270000 8.22e-01 1.40e-01
Nonhomologous End-Joining (NHEJ) 30 2.88e-02 7.40e-02 0.27300 0.271000 -0.028000 1.02e-02 7.91e-01
Interleukin-15 signaling 11 2.42e-01 3.57e-01 0.27300 -0.247000 0.115000 1.56e-01 5.10e-01
Hedgehog ligand biogenesis 50 6.42e-03 2.30e-02 0.27200 0.094900 0.255000 2.46e-01 1.87e-03
G-protein mediated events 40 1.35e-02 4.22e-02 0.27200 -0.268000 -0.042000 3.35e-03 6.46e-01
Purine ribonucleoside monophosphate biosynthesis 12 2.46e-01 3.63e-01 0.27100 0.024000 -0.270000 8.86e-01 1.05e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 59 3.26e-03 1.31e-02 0.27100 0.238000 0.129000 1.57e-03 8.61e-02
Aquaporin-mediated transport 29 6.41e-02 1.27e-01 0.27100 -0.216000 -0.164000 4.46e-02 1.27e-01
AMER1 mutants destabilize the destruction complex 13 2.94e-01 4.11e-01 0.27100 0.189000 0.194000 2.38e-01 2.27e-01
APC truncation mutants have impaired AXIN binding 13 2.94e-01 4.11e-01 0.27100 0.189000 0.194000 2.38e-01 2.27e-01
AXIN missense mutants destabilize the destruction complex 13 2.94e-01 4.11e-01 0.27100 0.189000 0.194000 2.38e-01 2.27e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 13 2.94e-01 4.11e-01 0.27100 0.189000 0.194000 2.38e-01 2.27e-01
Truncations of AMER1 destabilize the destruction complex 13 2.94e-01 4.11e-01 0.27100 0.189000 0.194000 2.38e-01 2.27e-01
truncated APC mutants destabilize the destruction complex 13 2.94e-01 4.11e-01 0.27100 0.189000 0.194000 2.38e-01 2.27e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 76 8.52e-04 4.38e-03 0.27000 0.195000 0.187000 3.41e-03 4.89e-03
Transcriptional regulation of pluripotent stem cells 11 2.47e-01 3.64e-01 0.27000 -0.120000 0.242000 4.92e-01 1.65e-01
Assembly of the pre-replicative complex 56 3.94e-03 1.53e-02 0.26900 0.094900 0.252000 2.20e-01 1.13e-03
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 1.49e-02 4.59e-02 0.26900 0.084600 0.255000 3.43e-01 4.23e-03
BMAL1:CLOCK,NPAS2 activates circadian gene expression 24 8.50e-02 1.57e-01 0.26900 -0.064100 -0.261000 5.87e-01 2.69e-02
Ubiquitin-dependent degradation of Cyclin D 44 1.25e-02 4.03e-02 0.26900 0.086900 0.254000 3.19e-01 3.56e-03
Metabolism of folate and pterines 13 2.55e-01 3.71e-01 0.26800 -0.265000 -0.042900 9.82e-02 7.89e-01
DNA Replication 111 3.35e-05 2.53e-04 0.26800 0.153000 0.220000 5.43e-03 6.28e-05
TP53 Regulates Transcription of Cell Cycle Genes 43 1.24e-02 4.02e-02 0.26800 0.063300 0.261000 4.73e-01 3.15e-03
Interleukin-12 family signaling 36 1.88e-02 5.41e-02 0.26800 0.000371 0.268000 9.97e-01 5.42e-03
Hh mutants abrogate ligand secretion 47 1.13e-02 3.71e-02 0.26700 0.113000 0.242000 1.81e-01 4.15e-03
Golgi Cisternae Pericentriolar Stack Reorganization 11 3.68e-01 4.82e-01 0.26600 0.189000 0.188000 2.79e-01 2.81e-01
Nuclear Events (kinase and transcription factor activation) 54 1.29e-03 6.09e-03 0.26600 -0.119000 0.238000 1.31e-01 2.52e-03
Presynaptic phase of homologous DNA pairing and strand exchange 29 5.22e-02 1.09e-01 0.26600 0.261000 0.051000 1.51e-02 6.35e-01
O-linked glycosylation of mucins 21 7.27e-02 1.41e-01 0.26500 -0.140000 0.225000 2.66e-01 7.39e-02
Telomere C-strand synthesis initiation 11 3.25e-01 4.41e-01 0.26500 0.261000 0.047200 1.34e-01 7.86e-01
Synthesis of DNA 106 6.72e-05 4.72e-04 0.26500 0.147000 0.221000 9.33e-03 9.10e-05
Misspliced GSK3beta mutants stabilize beta-catenin 14 2.83e-01 4.02e-01 0.26500 0.203000 0.170000 1.89e-01 2.71e-01
S33 mutants of beta-catenin aren't phosphorylated 14 2.83e-01 4.02e-01 0.26500 0.203000 0.170000 1.89e-01 2.71e-01
S37 mutants of beta-catenin aren't phosphorylated 14 2.83e-01 4.02e-01 0.26500 0.203000 0.170000 1.89e-01 2.71e-01
S45 mutants of beta-catenin aren't phosphorylated 14 2.83e-01 4.02e-01 0.26500 0.203000 0.170000 1.89e-01 2.71e-01
T41 mutants of beta-catenin aren't phosphorylated 14 2.83e-01 4.02e-01 0.26500 0.203000 0.170000 1.89e-01 2.71e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 14 2.83e-01 4.02e-01 0.26500 0.203000 0.170000 1.89e-01 2.71e-01
Interleukin-12 signaling 31 3.57e-02 8.43e-02 0.26400 -0.000325 0.264000 9.98e-01 1.09e-02
PLC beta mediated events 39 1.93e-02 5.54e-02 0.26400 -0.260000 -0.043900 4.95e-03 6.36e-01
Fcgamma receptor (FCGR) dependent phagocytosis 67 4.45e-04 2.40e-03 0.26400 -0.065200 0.255000 3.57e-01 3.05e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 43 1.75e-02 5.15e-02 0.26300 0.101000 0.243000 2.52e-01 5.80e-03
p53-Independent DNA Damage Response 43 1.75e-02 5.15e-02 0.26300 0.101000 0.243000 2.52e-01 5.80e-03
p53-Independent G1/S DNA damage checkpoint 43 1.75e-02 5.15e-02 0.26300 0.101000 0.243000 2.52e-01 5.80e-03
Negative regulation of FGFR2 signaling 19 1.28e-01 2.19e-01 0.26300 -0.011600 0.263000 9.30e-01 4.74e-02
Membrane binding and targetting of GAG proteins 10 3.32e-01 4.47e-01 0.26200 -0.032400 0.260000 8.59e-01 1.55e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 10 3.32e-01 4.47e-01 0.26200 -0.032400 0.260000 8.59e-01 1.55e-01
G1/S Transition 112 4.45e-05 3.29e-04 0.26100 0.127000 0.228000 2.07e-02 3.12e-05
Assembly of collagen fibrils and other multimeric structures 43 1.23e-02 4.00e-02 0.26100 -0.260000 -0.018400 3.16e-03 8.35e-01
Homology Directed Repair 82 8.06e-04 4.16e-03 0.26100 0.186000 0.183000 3.66e-03 4.23e-03
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 40 3.04e-02 7.55e-02 0.26100 0.169000 0.199000 6.43e-02 2.99e-02
Meiosis 38 1.79e-02 5.22e-02 0.26100 0.261000 -0.009640 5.47e-03 9.18e-01
Homologous DNA Pairing and Strand Exchange 30 5.52e-02 1.14e-01 0.26100 0.253000 0.060700 1.64e-02 5.65e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 3.78e-01 4.90e-01 0.26000 -0.140000 -0.219000 4.20e-01 2.09e-01
Estrogen-dependent gene expression 75 1.28e-03 6.07e-03 0.26000 0.227000 0.128000 7.09e-04 5.66e-02
tRNA processing in the mitochondrion 11 3.09e-01 4.25e-01 0.26000 0.021200 -0.259000 9.03e-01 1.37e-01
TICAM1, RIP1-mediated IKK complex recruitment 14 2.82e-01 4.02e-01 0.26000 0.112000 0.235000 4.70e-01 1.29e-01
Degradation of AXIN 47 1.39e-02 4.34e-02 0.25900 0.101000 0.239000 2.31e-01 4.66e-03
HATs acetylate histones 72 1.68e-03 7.58e-03 0.25900 0.229000 0.122000 8.12e-04 7.30e-02
HCMV Infection 68 2.08e-03 9.01e-03 0.25900 0.239000 0.099800 6.59e-04 1.55e-01
Phase I - Functionalization of compounds 39 3.16e-02 7.77e-02 0.25900 -0.226000 -0.126000 1.45e-02 1.73e-01
Metabolism of water-soluble vitamins and cofactors 89 1.40e-04 8.93e-04 0.25900 -0.021800 -0.258000 7.23e-01 2.69e-05
Dectin-1 mediated noncanonical NF-kB signaling 51 9.11e-03 3.09e-02 0.25900 0.083900 0.245000 3.01e-01 2.55e-03
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 22 8.16e-02 1.53e-01 0.25800 -0.089800 0.242000 4.66e-01 4.94e-02
HSF1-dependent transactivation 30 5.35e-02 1.11e-01 0.25800 0.035400 0.255000 7.37e-01 1.56e-02
Vitamin B5 (pantothenate) metabolism 15 1.74e-01 2.76e-01 0.25800 0.120000 -0.228000 4.21e-01 1.26e-01
Interleukin-6 signaling 10 3.06e-01 4.23e-01 0.25700 -0.202000 0.159000 2.68e-01 3.85e-01
RHO GTPase Effectors 173 1.37e-07 2.14e-06 0.25700 0.071600 0.247000 1.06e-01 2.43e-08
Deadenylation-dependent mRNA decay 53 7.50e-03 2.59e-02 0.25600 0.248000 0.063200 1.83e-03 4.26e-01
Interleukin-1 family signaling 102 6.51e-05 4.64e-04 0.25500 0.040000 0.252000 4.86e-01 1.13e-05
SHC-mediated cascade:FGFR3 10 4.05e-01 5.18e-01 0.25500 0.081400 0.242000 6.56e-01 1.85e-01
RHO GTPases activate PKNs 29 4.80e-02 1.05e-01 0.25400 -0.042400 0.250000 6.93e-01 1.97e-02
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 46 1.85e-02 5.34e-02 0.25400 0.104000 0.232000 2.24e-01 6.59e-03
Ion transport by P-type ATPases 34 4.81e-02 1.05e-01 0.25400 -0.241000 -0.079400 1.51e-02 4.23e-01
Transcriptional Regulation by MECP2 42 3.05e-02 7.56e-02 0.25400 -0.152000 -0.203000 8.90e-02 2.27e-02
Golgi Associated Vesicle Biogenesis 49 1.69e-02 5.05e-02 0.25300 0.210000 0.142000 1.13e-02 8.50e-02
Interleukin-6 family signaling 16 1.84e-01 2.87e-01 0.25300 -0.246000 0.058700 8.88e-02 6.84e-01
Mitotic Prometaphase 137 5.66e-06 5.31e-05 0.25200 0.242000 0.071500 1.09e-06 1.50e-01
Activation of NF-kappaB in B cells 56 6.94e-03 2.44e-02 0.25100 0.062800 0.243000 4.17e-01 1.69e-03
Integrin cell surface interactions 45 7.72e-03 2.64e-02 0.25100 -0.232000 0.096300 7.26e-03 2.64e-01
Signaling by high-kinase activity BRAF mutants 27 5.53e-02 1.14e-01 0.25000 -0.088200 0.234000 4.28e-01 3.51e-02
Synthesis of PIPs at the early endosome membrane 16 2.73e-01 3.94e-01 0.25000 0.152000 0.199000 2.92e-01 1.69e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 10 3.58e-01 4.73e-01 0.25000 -0.245000 0.050400 1.80e-01 7.83e-01
Protein localization 136 5.46e-06 5.18e-05 0.24900 -0.045800 -0.245000 3.58e-01 8.56e-07
Gap-filling DNA repair synthesis and ligation in GG-NER 23 1.59e-01 2.57e-01 0.24900 0.155000 0.195000 1.99e-01 1.05e-01
Cytochrome P450 - arranged by substrate type 18 2.39e-01 3.55e-01 0.24800 -0.191000 -0.159000 1.62e-01 2.42e-01
Infectious disease 533 2.75e-19 4.24e-17 0.24800 0.091300 0.231000 3.74e-04 2.14e-19
Regulation of TP53 Activity 134 1.61e-05 1.34e-04 0.24800 0.229000 0.094600 5.16e-06 5.94e-02
ER-Phagosome pathway 61 5.32e-03 1.97e-02 0.24700 0.063600 0.239000 3.91e-01 1.28e-03
Negative regulation of NOTCH4 signaling 47 1.54e-02 4.71e-02 0.24700 0.039400 0.244000 6.41e-01 3.86e-03
Regulation of TNFR1 signaling 26 7.62e-02 1.46e-01 0.24700 -0.243000 0.043700 3.23e-02 7.00e-01
ERK/MAPK targets 22 1.63e-01 2.63e-01 0.24600 -0.229000 -0.090900 6.37e-02 4.61e-01
Signaling by FGFR2 in disease 28 1.08e-01 1.91e-01 0.24600 0.123000 0.213000 2.60e-01 5.17e-02
Apoptotic factor-mediated response 13 2.92e-01 4.11e-01 0.24500 -0.014800 0.245000 9.27e-01 1.26e-01
Ras activation upon Ca2+ influx through NMDA receptor 13 3.59e-01 4.74e-01 0.24500 -0.209000 -0.128000 1.92e-01 4.24e-01
Keratan sulfate biosynthesis 17 1.61e-01 2.60e-01 0.24500 -0.198000 0.145000 1.59e-01 3.00e-01
Trafficking of GluR2-containing AMPA receptors 10 3.40e-01 4.54e-01 0.24500 -0.162000 0.184000 3.75e-01 3.14e-01
E3 ubiquitin ligases ubiquitinate target proteins 39 4.84e-02 1.05e-01 0.24500 0.198000 0.145000 3.26e-02 1.18e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 16 2.54e-01 3.70e-01 0.24500 0.239000 0.055800 9.86e-02 7.00e-01
NIK-->noncanonical NF-kB signaling 50 1.59e-02 4.83e-02 0.24500 0.077700 0.232000 3.42e-01 4.56e-03
TCR signaling 79 1.27e-03 6.01e-03 0.24400 0.056900 0.237000 3.83e-01 2.69e-04
Interleukin receptor SHC signaling 15 2.35e-01 3.51e-01 0.24300 -0.044200 0.239000 7.67e-01 1.09e-01
eNOS activation 10 3.48e-01 4.64e-01 0.24200 -0.183000 0.159000 3.17e-01 3.84e-01
Cytosolic sensors of pathogen-associated DNA 52 2.01e-02 5.73e-02 0.24200 0.190000 0.149000 1.77e-02 6.36e-02
Neurotransmitter release cycle 22 1.41e-01 2.34e-01 0.24200 0.005280 0.241000 9.66e-01 5.00e-02
FCERI mediated Ca+2 mobilization 18 2.40e-01 3.56e-01 0.24100 -0.223000 -0.091500 1.01e-01 5.02e-01
Signaling by MET 53 9.20e-03 3.11e-02 0.24100 0.007420 0.241000 9.26e-01 2.42e-03
Mitotic G1 phase and G1/S transition 127 5.57e-05 4.01e-04 0.24100 0.099800 0.219000 5.29e-02 2.16e-05
Signaling by ROBO receptors 151 1.15e-06 1.33e-05 0.24000 -0.021000 0.239000 6.58e-01 4.13e-07
Vasopressin regulates renal water homeostasis via Aquaporins 27 1.28e-01 2.19e-01 0.24000 -0.209000 -0.119000 6.04e-02 2.86e-01
G1/S DNA Damage Checkpoints 57 1.26e-02 4.03e-02 0.24000 0.105000 0.216000 1.72e-01 4.85e-03
Defective CFTR causes cystic fibrosis 50 2.19e-02 6.09e-02 0.23900 0.099400 0.217000 2.25e-01 7.99e-03
Nucleobase biosynthesis 15 2.53e-01 3.70e-01 0.23900 0.031700 -0.236000 8.32e-01 1.13e-01
Nucleotide Excision Repair 102 4.26e-04 2.33e-03 0.23800 0.218000 0.094800 1.43e-04 9.89e-02
Antigen processing-Cross presentation 69 3.72e-03 1.46e-02 0.23800 0.048600 0.233000 4.86e-01 8.31e-04
Glycosaminoglycan metabolism 81 2.96e-04 1.67e-03 0.23700 -0.153000 0.181000 1.77e-02 4.84e-03
Role of phospholipids in phagocytosis 14 3.65e-01 4.79e-01 0.23700 -0.165000 -0.170000 2.85e-01 2.71e-01
Switching of origins to a post-replicative state 79 3.38e-03 1.35e-02 0.23600 0.134000 0.194000 3.98e-02 2.87e-03
Downstream TCR signaling 67 6.27e-03 2.27e-02 0.23600 0.086600 0.220000 2.21e-01 1.91e-03
RHO GTPases activate KTN1 10 4.76e-01 5.85e-01 0.23600 0.107000 0.210000 5.60e-01 2.49e-01
Ion channel transport 91 1.46e-03 6.75e-03 0.23600 -0.193000 -0.135000 1.48e-03 2.60e-02
SLC-mediated transmembrane transport 120 2.65e-05 2.08e-04 0.23600 -0.234000 0.024900 9.69e-06 6.39e-01
Class A/1 (Rhodopsin-like receptors) 39 2.42e-02 6.51e-02 0.23600 -0.088900 0.218000 3.37e-01 1.84e-02
TNFR2 non-canonical NF-kB pathway 63 3.94e-03 1.53e-02 0.23500 -0.024300 0.234000 7.39e-01 1.34e-03
G alpha (z) signalling events 29 9.49e-02 1.72e-01 0.23500 -0.233000 -0.031500 3.01e-02 7.69e-01
TNFR1-induced NFkappaB signaling pathway 21 1.82e-01 2.86e-01 0.23500 -0.233000 -0.030500 6.51e-02 8.09e-01
Cell Cycle 484 4.05e-15 3.56e-13 0.23400 0.193000 0.134000 7.18e-13 6.28e-07
G alpha (12/13) signalling events 54 1.31e-02 4.12e-02 0.23400 -0.232000 -0.029900 3.25e-03 7.05e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 11 4.28e-01 5.38e-01 0.23400 0.059300 0.226000 7.34e-01 1.95e-01
Uptake and function of anthrax toxins 11 4.32e-01 5.43e-01 0.23300 -0.224000 -0.065900 1.99e-01 7.05e-01
Nicotinate metabolism 20 2.43e-01 3.58e-01 0.23300 -0.128000 -0.195000 3.22e-01 1.32e-01
G alpha (i) signalling events 127 1.32e-05 1.12e-04 0.23300 -0.228000 0.049500 1.01e-05 3.37e-01
Cell Cycle, Mitotic 397 2.27e-12 1.04e-10 0.23300 0.182000 0.144000 6.23e-10 9.94e-07
Chaperonin-mediated protein folding 69 7.09e-03 2.48e-02 0.23300 0.106000 0.207000 1.29e-01 2.98e-03
Cross-presentation of soluble exogenous antigens (endosomes) 40 4.71e-02 1.03e-01 0.23200 0.058000 0.225000 5.26e-01 1.38e-02
SHC-mediated cascade:FGFR2 10 3.94e-01 5.07e-01 0.23200 -0.091500 0.213000 6.16e-01 2.43e-01
Signaling by Interleukins 278 2.95e-11 1.14e-09 0.23200 -0.054200 0.226000 1.23e-01 1.24e-10
HCMV Late Events 43 4.08e-02 9.31e-02 0.23200 0.220000 0.070600 1.24e-02 4.24e-01
Adenylate cyclase inhibitory pathway 11 4.24e-01 5.34e-01 0.23100 -0.228000 -0.037900 1.90e-01 8.28e-01
p53-Dependent G1 DNA Damage Response 56 1.79e-02 5.22e-02 0.23100 0.091700 0.212000 2.36e-01 6.17e-03
p53-Dependent G1/S DNA damage checkpoint 56 1.79e-02 5.22e-02 0.23100 0.091700 0.212000 2.36e-01 6.17e-03
Protein folding 75 4.50e-03 1.72e-02 0.23000 0.084000 0.214000 2.09e-01 1.35e-03
Interleukin-1 signaling 84 1.57e-03 7.23e-03 0.23000 0.036700 0.227000 5.62e-01 3.26e-04
Signaling by PDGFRA extracellular domain mutants 11 4.58e-01 5.67e-01 0.23000 0.098600 0.208000 5.72e-01 2.33e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 11 4.58e-01 5.67e-01 0.23000 0.098600 0.208000 5.72e-01 2.33e-01
WNT5A-dependent internalization of FZD4 13 2.96e-01 4.13e-01 0.23000 -0.196000 0.121000 2.22e-01 4.51e-01
Interferon gamma signaling 44 2.11e-02 5.90e-02 0.22900 -0.059700 0.222000 4.94e-01 1.11e-02
SUMOylation of transcription cofactors 38 5.11e-02 1.08e-01 0.22900 0.228000 0.022800 1.50e-02 8.08e-01
trans-Golgi Network Vesicle Budding 63 1.44e-02 4.47e-02 0.22900 0.157000 0.167000 3.10e-02 2.21e-02
Degradation of beta-catenin by the destruction complex 72 6.71e-03 2.38e-02 0.22900 0.108000 0.203000 1.15e-01 3.00e-03
Autodegradation of the E3 ubiquitin ligase COP1 44 4.49e-02 1.00e-01 0.22900 0.094800 0.209000 2.77e-01 1.68e-02
M Phase 275 9.43e-09 2.08e-07 0.22900 0.195000 0.120000 3.05e-08 6.90e-04
Cell-Cell communication 72 1.19e-03 5.74e-03 0.22900 -0.154000 0.169000 2.37e-02 1.34e-02
Signaling by FGFR3 fusions in cancer 10 5.05e-01 6.09e-01 0.22900 0.192000 0.124000 2.93e-01 4.96e-01
Signaling by NTRKs 113 4.09e-05 3.04e-04 0.22800 -0.091600 0.209000 9.34e-02 1.28e-04
Activation of gene expression by SREBF (SREBP) 40 5.70e-02 1.17e-01 0.22800 -0.215000 -0.076600 1.87e-02 4.02e-01
Cyclin A:Cdk2-associated events at S phase entry 77 4.68e-03 1.77e-02 0.22800 0.094600 0.208000 1.52e-01 1.67e-03
Activation of BH3-only proteins 25 1.06e-01 1.89e-01 0.22800 -0.090900 0.209000 4.32e-01 7.09e-02
Metabolism of nitric oxide: NOS3 activation and regulation 13 3.00e-01 4.16e-01 0.22700 -0.141000 0.178000 3.77e-01 2.66e-01
Metalloprotease DUBs 15 3.28e-01 4.43e-01 0.22700 0.223000 0.045700 1.36e-01 7.59e-01
Senescence-Associated Secretory Phenotype (SASP) 45 3.58e-02 8.45e-02 0.22700 0.046200 0.222000 5.92e-01 9.93e-03
Vif-mediated degradation of APOBEC3G 43 4.94e-02 1.06e-01 0.22700 0.085500 0.210000 3.33e-01 1.71e-02
ROS and RNS production in phagocytes 20 1.88e-01 2.92e-01 0.22700 -0.036600 0.224000 7.77e-01 8.30e-02
Receptor Mediated Mitophagy 11 3.75e-01 4.88e-01 0.22600 0.205000 -0.096800 2.40e-01 5.78e-01
Lysosome Vesicle Biogenesis 27 1.61e-01 2.60e-01 0.22600 0.108000 0.199000 3.32e-01 7.42e-02
Meiotic synapsis 22 1.87e-01 2.91e-01 0.22600 0.225000 0.019800 6.79e-02 8.73e-01
Signaling by NTRK1 (TRKA) 97 2.24e-04 1.35e-03 0.22600 -0.080800 0.211000 1.70e-01 3.45e-04
Retrograde transport at the Trans-Golgi-Network 43 2.09e-02 5.90e-02 0.22600 0.191000 -0.120000 3.05e-02 1.73e-01
RIPK1-mediated regulated necrosis 22 1.36e-01 2.28e-01 0.22600 -0.131000 0.184000 2.90e-01 1.36e-01
Regulated Necrosis 22 1.36e-01 2.28e-01 0.22600 -0.131000 0.184000 2.90e-01 1.36e-01
Regulation of necroptotic cell death 22 1.36e-01 2.28e-01 0.22600 -0.131000 0.184000 2.90e-01 1.36e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 73 6.96e-03 2.44e-02 0.22500 0.206000 0.091800 2.42e-03 1.76e-01
Signaling by Non-Receptor Tyrosine Kinases 42 3.02e-02 7.53e-02 0.22500 -0.050700 0.219000 5.70e-01 1.42e-02
Signaling by PTK6 42 3.02e-02 7.53e-02 0.22500 -0.050700 0.219000 5.70e-01 1.42e-02
Processive synthesis on the C-strand of the telomere 19 2.84e-01 4.03e-01 0.22400 0.109000 0.195000 4.09e-01 1.41e-01
RNA Polymerase I Promoter Clearance 43 6.41e-02 1.27e-01 0.22300 0.161000 0.155000 6.78e-02 7.95e-02
Diseases associated with N-glycosylation of proteins 16 3.55e-01 4.71e-01 0.22300 0.130000 0.182000 3.68e-01 2.09e-01
Protein ubiquitination 56 2.68e-02 7.04e-02 0.22300 0.185000 0.124000 1.65e-02 1.08e-01
Keratan sulfate/keratin metabolism 22 1.40e-01 2.33e-01 0.22300 -0.169000 0.146000 1.70e-01 2.38e-01
Signaling by Hippo 18 3.07e-01 4.24e-01 0.22300 0.106000 0.196000 4.35e-01 1.51e-01
Repression of WNT target genes 11 4.64e-01 5.73e-01 0.22200 0.057900 0.215000 7.40e-01 2.18e-01
S Phase 144 1.19e-04 7.94e-04 0.22200 0.143000 0.170000 3.17e-03 4.49e-04
Regulation of ornithine decarboxylase (ODC) 44 4.97e-02 1.07e-01 0.22200 0.067700 0.211000 4.37e-01 1.55e-02
DARPP-32 events 21 2.49e-01 3.67e-01 0.22200 -0.202000 -0.090100 1.09e-01 4.75e-01
Activation of SMO 12 4.62e-01 5.71e-01 0.22100 -0.189000 -0.115000 2.57e-01 4.91e-01
Vpu mediated degradation of CD4 43 5.75e-02 1.17e-01 0.22100 0.081000 0.205000 3.59e-01 1.99e-02
Methylation 10 4.98e-01 6.02e-01 0.22100 -0.048600 -0.215000 7.90e-01 2.38e-01
RNA Polymerase I Transcription 44 6.40e-02 1.27e-01 0.22100 0.144000 0.167000 9.77e-02 5.57e-02
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 10 4.26e-01 5.37e-01 0.22000 0.194000 -0.104000 2.88e-01 5.68e-01
SUMOylation 137 1.35e-04 8.72e-04 0.22000 0.203000 0.086500 4.46e-05 8.16e-02
Other semaphorin interactions 14 4.13e-01 5.25e-01 0.22000 -0.183000 -0.123000 2.37e-01 4.26e-01
LDL clearance 14 3.65e-01 4.79e-01 0.22000 0.022900 0.219000 8.82e-01 1.57e-01
Neutrophil degranulation 292 1.03e-10 3.71e-09 0.21900 -0.060700 0.211000 7.65e-02 7.43e-10
Adherens junctions interactions 11 4.17e-01 5.28e-01 0.21900 -0.213000 0.050000 2.21e-01 7.74e-01
DNA Double-Strand Break Repair 109 1.16e-03 5.68e-03 0.21900 0.183000 0.120000 9.98e-04 3.04e-02
Binding and Uptake of Ligands by Scavenger Receptors 23 1.38e-01 2.31e-01 0.21900 -0.152000 0.157000 2.06e-01 1.92e-01
Formation of the beta-catenin:TCF transactivating complex 28 1.79e-01 2.82e-01 0.21900 0.158000 0.151000 1.47e-01 1.67e-01
Opioid Signalling 64 1.63e-02 4.91e-02 0.21900 -0.200000 -0.087700 5.66e-03 2.26e-01
CDT1 association with the CDC6:ORC:origin complex 48 5.17e-02 1.09e-01 0.21800 0.120000 0.182000 1.52e-01 2.93e-02
Regulation of PTEN mRNA translation 11 4.05e-01 5.18e-01 0.21800 0.090400 -0.198000 6.04e-01 2.56e-01
Transport of vitamins, nucleosides, and related molecules 24 1.47e-01 2.41e-01 0.21700 -0.205000 0.069700 8.17e-02 5.55e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 52 1.72e-02 5.12e-02 0.21700 -0.054400 0.210000 4.98e-01 8.89e-03
Stabilization of p53 48 5.33e-02 1.11e-01 0.21700 0.121000 0.180000 1.48e-01 3.11e-02
Neuronal System 174 4.06e-06 4.03e-05 0.21600 -0.216000 0.001900 9.32e-07 9.66e-01
Signaling by PDGF 46 2.21e-02 6.10e-02 0.21600 -0.181000 0.118000 3.36e-02 1.67e-01
Signaling by NODAL 10 5.48e-01 6.47e-01 0.21600 -0.168000 -0.136000 3.58e-01 4.57e-01
Synthesis of pyrophosphates in the cytosol 10 4.83e-01 5.89e-01 0.21600 0.007670 -0.216000 9.67e-01 2.38e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 11 4.96e-01 6.00e-01 0.21600 -0.202000 -0.075600 2.46e-01 6.64e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 11 4.96e-01 6.00e-01 0.21600 -0.202000 -0.075600 2.46e-01 6.64e-01
Regulation of RAS by GAPs 57 2.88e-02 7.40e-02 0.21500 0.088800 0.196000 2.47e-01 1.05e-02
Metabolism of polyamines 50 4.48e-02 9.99e-02 0.21500 0.089700 0.196000 2.73e-01 1.69e-02
Cyclin E associated events during G1/S transition 75 9.48e-03 3.17e-02 0.21500 0.086900 0.197000 1.94e-01 3.28e-03
HDR through Homologous Recombination (HRR) 49 5.47e-02 1.13e-01 0.21500 0.170000 0.131000 3.95e-02 1.14e-01
SCF-beta-TrCP mediated degradation of Emi1 45 5.55e-02 1.14e-01 0.21500 0.061700 0.206000 4.75e-01 1.72e-02
CDK-mediated phosphorylation and removal of Cdc6 63 2.37e-02 6.43e-02 0.21400 0.125000 0.174000 8.68e-02 1.69e-02
Gap junction trafficking 11 5.06e-01 6.09e-01 0.21400 0.089000 0.195000 6.09e-01 2.63e-01
Cell junction organization 46 2.93e-02 7.42e-02 0.21300 -0.203000 0.064800 1.71e-02 4.47e-01
Regulation of TP53 Degradation 32 1.21e-01 2.09e-01 0.21300 0.210000 0.037200 3.99e-02 7.16e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 28 1.13e-01 1.99e-01 0.21300 -0.078600 0.198000 4.72e-01 6.99e-02
Signaling by RAF1 mutants 32 7.57e-02 1.46e-01 0.21300 -0.176000 0.120000 8.58e-02 2.39e-01
EGFR downregulation 22 2.78e-01 4.00e-01 0.21300 0.154000 0.147000 2.12e-01 2.32e-01
Platelet degranulation 86 9.51e-04 4.80e-03 0.21300 -0.142000 0.158000 2.28e-02 1.13e-02
Retrograde neurotrophin signalling 11 4.77e-01 5.85e-01 0.21300 0.022800 0.212000 8.96e-01 2.25e-01
Post-translational protein phosphorylation 63 7.30e-03 2.54e-02 0.21300 -0.086400 0.194000 2.37e-01 7.68e-03
Reproduction 44 4.65e-02 1.03e-01 0.21200 0.212000 -0.004140 1.49e-02 9.62e-01
Regulation of TP53 Activity through Acetylation 28 1.98e-01 3.05e-01 0.21200 0.162000 0.138000 1.39e-01 2.08e-01
Signaling by GPCR 270 6.17e-09 1.49e-07 0.21200 -0.211000 0.020900 2.92e-09 5.57e-01
Diseases of programmed cell death 24 1.67e-01 2.67e-01 0.21200 -0.051800 0.206000 6.61e-01 8.15e-02
Transport of bile salts and organic acids, metal ions and amine compounds 32 8.07e-02 1.52e-01 0.21200 -0.099100 0.187000 3.32e-01 6.68e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs 55 3.75e-02 8.69e-02 0.21200 0.094600 0.190000 2.26e-01 1.52e-02
Purine salvage 13 3.88e-01 5.00e-01 0.21100 -0.207000 0.040100 1.96e-01 8.02e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 16 3.96e-01 5.09e-01 0.21000 -0.177000 -0.114000 2.21e-01 4.28e-01
Netrin-1 signaling 38 8.88e-02 1.62e-01 0.21000 -0.206000 -0.040300 2.78e-02 6.67e-01
Regulation of Apoptosis 45 6.69e-02 1.31e-01 0.21000 0.078200 0.195000 3.64e-01 2.36e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 31 1.66e-01 2.67e-01 0.21000 0.108000 0.180000 2.99e-01 8.27e-02
Cargo concentration in the ER 21 2.51e-01 3.68e-01 0.21000 0.209000 0.019100 9.73e-02 8.80e-01
SUMO E3 ligases SUMOylate target proteins 131 4.47e-04 2.40e-03 0.21000 0.193000 0.083000 1.48e-04 1.02e-01
ER Quality Control Compartment (ERQC) 18 3.56e-01 4.71e-01 0.20800 0.101000 0.182000 4.58e-01 1.81e-01
GPCR downstream signalling 245 6.85e-08 1.19e-06 0.20800 -0.207000 0.017800 2.64e-08 6.33e-01
Plasma lipoprotein assembly, remodeling, and clearance 39 7.63e-02 1.46e-01 0.20800 -0.208000 -0.005640 2.47e-02 9.51e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 18 2.60e-01 3.76e-01 0.20800 -0.084400 0.190000 5.36e-01 1.63e-01
Neurodegenerative Diseases 18 2.60e-01 3.76e-01 0.20800 -0.084400 0.190000 5.36e-01 1.63e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 5.70e-02 1.17e-01 0.20800 -0.096300 -0.184000 2.39e-01 2.43e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 62 3.20e-02 7.81e-02 0.20700 0.121000 0.169000 1.01e-01 2.18e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 62 3.20e-02 7.81e-02 0.20700 0.121000 0.169000 1.01e-01 2.18e-02
Peptide ligand-binding receptors 22 1.99e-01 3.06e-01 0.20700 -0.071500 0.195000 5.62e-01 1.14e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 63 3.15e-02 7.76e-02 0.20700 0.134000 0.158000 6.60e-02 3.07e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 63 3.15e-02 7.76e-02 0.20700 0.134000 0.158000 6.60e-02 3.07e-02
Signaling by PDGFR in disease 17 3.79e-01 4.91e-01 0.20700 0.092700 0.185000 5.08e-01 1.87e-01
RAB geranylgeranylation 41 7.44e-02 1.44e-01 0.20700 0.206000 0.021900 2.29e-02 8.09e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 36 6.47e-02 1.27e-01 0.20700 -0.167000 0.122000 8.40e-02 2.05e-01
Signaling by RAS mutants 36 6.47e-02 1.27e-01 0.20700 -0.167000 0.122000 8.40e-02 2.05e-01
Signaling by moderate kinase activity BRAF mutants 36 6.47e-02 1.27e-01 0.20700 -0.167000 0.122000 8.40e-02 2.05e-01
Signaling downstream of RAS mutants 36 6.47e-02 1.27e-01 0.20700 -0.167000 0.122000 8.40e-02 2.05e-01
MAP2K and MAPK activation 31 1.04e-01 1.86e-01 0.20700 -0.074100 0.193000 4.76e-01 6.34e-02
Notch-HLH transcription pathway 24 2.00e-01 3.06e-01 0.20600 -0.206000 0.014100 8.10e-02 9.05e-01
Glycerophospholipid biosynthesis 82 1.19e-02 3.90e-02 0.20600 -0.136000 -0.154000 3.37e-02 1.59e-02
SHC1 events in ERBB2 signaling 15 3.22e-01 4.39e-01 0.20500 -0.163000 0.125000 2.75e-01 4.01e-01
Regulation of TP53 Expression and Degradation 33 1.21e-01 2.09e-01 0.20500 0.205000 0.009130 4.16e-02 9.28e-01
Nervous system development 395 3.49e-13 2.15e-11 0.20500 -0.117000 0.169000 7.65e-05 1.19e-08
Negative regulation of FGFR1 signaling 19 3.09e-01 4.25e-01 0.20500 0.027500 0.203000 8.36e-01 1.25e-01
EPH-ephrin mediated repulsion of cells 37 6.21e-02 1.25e-01 0.20500 -0.125000 0.162000 1.88e-01 8.77e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 7.67e-02 1.46e-01 0.20500 0.090700 0.183000 2.88e-01 3.15e-02
Negative regulation of FGFR4 signaling 19 2.90e-01 4.10e-01 0.20400 -0.010300 0.204000 9.38e-01 1.25e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 66 8.38e-03 2.85e-02 0.20300 -0.101000 0.176000 1.56e-01 1.34e-02
Transcriptional regulation by RUNX3 86 4.71e-03 1.77e-02 0.20300 0.005620 0.203000 9.28e-01 1.19e-03
VEGFA-VEGFR2 Pathway 77 3.56e-03 1.41e-02 0.20300 -0.128000 0.157000 5.26e-02 1.74e-02
Integration of energy metabolism 72 1.63e-02 4.91e-02 0.20200 -0.194000 -0.056500 4.42e-03 4.08e-01
TGF-beta receptor signaling activates SMADs 29 2.07e-01 3.17e-01 0.20200 0.095000 0.179000 3.76e-01 9.61e-02
Fanconi Anemia Pathway 25 2.41e-01 3.57e-01 0.20200 0.193000 0.059600 9.50e-02 6.06e-01
COPI-dependent Golgi-to-ER retrograde traffic 62 3.99e-02 9.15e-02 0.20200 0.137000 0.148000 6.32e-02 4.39e-02
Synthesis of PA 21 3.34e-01 4.49e-01 0.20100 -0.132000 -0.152000 2.95e-01 2.28e-01
Global Genome Nucleotide Excision Repair (GG-NER) 78 1.24e-02 4.00e-02 0.20100 0.193000 0.055000 3.25e-03 4.02e-01
RNA Polymerase III Abortive And Retractive Initiation 39 1.08e-01 1.91e-01 0.20100 0.195000 0.049000 3.56e-02 5.97e-01
RNA Polymerase III Transcription 39 1.08e-01 1.91e-01 0.20100 0.195000 0.049000 3.56e-02 5.97e-01
Downregulation of TGF-beta receptor signaling 24 2.86e-01 4.04e-01 0.20100 0.115000 0.164000 3.29e-01 1.64e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 5.59e-01 6.55e-01 0.20000 -0.197000 -0.034100 2.80e-01 8.52e-01
alpha-linolenic acid (ALA) metabolism 10 5.59e-01 6.55e-01 0.20000 -0.197000 -0.034100 2.80e-01 8.52e-01
Metabolism of vitamins and cofactors 126 1.12e-03 5.53e-03 0.19900 -0.071400 -0.186000 1.68e-01 3.17e-04
Inositol phosphate metabolism 39 1.19e-01 2.06e-01 0.19900 -0.187000 -0.068300 4.32e-02 4.61e-01
Cell death signalling via NRAGE, NRIF and NADE 57 3.20e-02 7.81e-02 0.19900 -0.199000 -0.005390 9.38e-03 9.44e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 38 6.72e-02 1.31e-01 0.19900 -0.134000 0.147000 1.53e-01 1.17e-01
Signaling by TGF-beta Receptor Complex 66 3.45e-02 8.24e-02 0.19900 0.119000 0.160000 9.64e-02 2.50e-02
APC/C-mediated degradation of cell cycle proteins 72 2.68e-02 7.04e-02 0.19800 0.135000 0.146000 4.85e-02 3.28e-02
Regulation of mitotic cell cycle 72 2.68e-02 7.04e-02 0.19800 0.135000 0.146000 4.85e-02 3.28e-02
FRS-mediated FGFR3 signaling 12 5.31e-01 6.31e-01 0.19800 0.085500 0.179000 6.08e-01 2.83e-01
HDR through Single Strand Annealing (SSA) 30 1.75e-01 2.77e-01 0.19800 0.197000 0.024000 6.21e-02 8.20e-01
DNA Repair 242 3.07e-06 3.18e-05 0.19800 0.184000 0.072600 9.08e-07 5.32e-02
Cellular responses to external stimuli 410 3.29e-10 9.94e-09 0.19800 0.049900 0.191000 8.62e-02 4.74e-11
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 4.45e-01 5.57e-01 0.19700 0.061000 0.187000 6.83e-01 2.09e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 19 2.91e-01 4.10e-01 0.19700 -0.189000 0.054100 1.53e-01 6.83e-01
Trafficking of AMPA receptors 19 2.91e-01 4.10e-01 0.19700 -0.189000 0.054100 1.53e-01 6.83e-01
Ovarian tumor domain proteases 31 1.98e-01 3.05e-01 0.19700 0.080000 0.180000 4.41e-01 8.33e-02
Cellular responses to stress 406 4.76e-10 1.36e-08 0.19700 0.049000 0.190000 9.36e-02 6.79e-11
Response to elevated platelet cytosolic Ca2+ 89 2.19e-03 9.33e-03 0.19600 -0.138000 0.139000 2.42e-02 2.36e-02
Synthesis of substrates in N-glycan biosythesis 52 2.91e-02 7.42e-02 0.19600 -0.107000 0.164000 1.82e-01 4.09e-02
Neurotransmitter receptors and postsynaptic signal transmission 96 4.51e-03 1.72e-02 0.19600 -0.194000 -0.023300 1.03e-03 6.94e-01
Signaling by FGFR3 29 2.33e-01 3.49e-01 0.19500 0.099200 0.168000 3.56e-01 1.17e-01
G1/S-Specific Transcription 21 3.61e-01 4.76e-01 0.19500 0.138000 0.137000 2.75e-01 2.76e-01
Activation of kainate receptors upon glutamate binding 17 4.17e-01 5.28e-01 0.19400 -0.180000 -0.072200 1.98e-01 6.06e-01
UCH proteinases 74 2.27e-02 6.21e-02 0.19400 0.071700 0.180000 2.87e-01 7.37e-03
Thrombin signalling through proteinase activated receptors (PARs) 20 2.85e-01 4.04e-01 0.19400 -0.049800 0.187000 7.00e-01 1.47e-01
Rap1 signalling 14 4.92e-01 5.98e-01 0.19400 0.078500 0.177000 6.11e-01 2.52e-01
Downstream signal transduction 27 1.74e-01 2.76e-01 0.19300 -0.176000 0.080800 1.14e-01 4.68e-01
Molecules associated with elastic fibres 25 2.59e-01 3.76e-01 0.19300 0.033300 0.190000 7.74e-01 1.00e-01
Termination of translesion DNA synthesis 28 2.52e-01 3.69e-01 0.19300 0.091800 0.170000 4.01e-01 1.21e-01
APC-Cdc20 mediated degradation of Nek2A 21 3.14e-01 4.31e-01 0.19200 0.192000 0.018800 1.29e-01 8.81e-01
COPII-mediated vesicle transport 56 5.86e-02 1.19e-01 0.19200 0.181000 0.066300 1.96e-02 3.91e-01
Axon guidance 378 4.45e-11 1.66e-09 0.19200 -0.103000 0.162000 6.49e-04 9.05e-08
Sphingolipid metabolism 64 2.19e-02 6.09e-02 0.19200 -0.036000 0.188000 6.19e-01 9.36e-03
Cyclin D associated events in G1 41 1.33e-01 2.24e-01 0.19100 0.078100 0.175000 3.87e-01 5.31e-02
G1 Phase 41 1.33e-01 2.24e-01 0.19100 0.078100 0.175000 3.87e-01 5.31e-02
Potential therapeutics for SARS 66 2.10e-02 5.90e-02 0.19100 -0.026600 0.189000 7.09e-01 7.96e-03
VEGFR2 mediated cell proliferation 16 4.69e-01 5.78e-01 0.19100 -0.159000 -0.105000 2.72e-01 4.66e-01
MECP2 regulates neuronal receptors and channels 10 6.25e-01 7.10e-01 0.19000 0.154000 0.113000 4.01e-01 5.37e-01
RAS processing 18 3.13e-01 4.31e-01 0.19000 -0.156000 0.109000 2.53e-01 4.23e-01
Regulation of APC/C activators between G1/S and early anaphase 67 4.46e-02 9.98e-02 0.18900 0.108000 0.155000 1.26e-01 2.80e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 63 5.48e-02 1.13e-01 0.18900 0.117000 0.149000 1.08e-01 4.14e-02
Interleukin-2 family signaling 22 2.51e-01 3.68e-01 0.18900 -0.168000 0.087700 1.73e-01 4.77e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 19 4.02e-01 5.15e-01 0.18900 0.171000 0.081300 1.97e-01 5.40e-01
Removal of the Flap Intermediate from the C-strand 17 4.59e-01 5.67e-01 0.18900 0.138000 0.129000 3.25e-01 3.56e-01
Degradation of DVL 48 7.83e-02 1.48e-01 0.18900 0.016200 0.188000 8.46e-01 2.45e-02
Synthesis of IP2, IP, and Ins in the cytosol 12 4.99e-01 6.02e-01 0.18900 -0.033100 0.186000 8.43e-01 2.66e-01
SARS-CoV-2 Infection 56 5.11e-02 1.08e-01 0.18800 0.013900 0.188000 8.57e-01 1.52e-02
Degradation of GLI2 by the proteasome 50 7.59e-02 1.46e-01 0.18800 0.030400 0.186000 7.10e-01 2.32e-02
Post NMDA receptor activation events 44 9.29e-02 1.69e-01 0.18800 -0.188000 -0.003140 3.12e-02 9.71e-01
Cytokine Signaling in Immune system 518 5.88e-13 3.30e-11 0.18800 -0.027500 0.186000 2.91e-01 8.82e-13
PCP/CE pathway 79 1.28e-02 4.05e-02 0.18800 -0.013200 0.187000 8.39e-01 4.09e-03
Leishmania infection 118 8.05e-04 4.16e-03 0.18700 -0.079100 0.170000 1.39e-01 1.49e-03
Diseases associated with O-glycosylation of proteins 33 1.71e-01 2.72e-01 0.18700 -0.187000 -0.002340 6.34e-02 9.81e-01
RNA Polymerase I Transcription Initiation 40 1.67e-01 2.67e-01 0.18700 0.144000 0.119000 1.16e-01 1.94e-01
VLDLR internalisation and degradation 11 5.15e-01 6.16e-01 0.18600 -0.170000 0.077100 3.30e-01 6.58e-01
Negative regulators of DDX58/IFIH1 signaling 29 1.67e-01 2.67e-01 0.18600 -0.113000 0.148000 2.94e-01 1.69e-01
DNA Damage Bypass 43 1.48e-01 2.42e-01 0.18500 0.155000 0.101000 7.92e-02 2.54e-01
Signaling by BRAF and RAF fusions 52 4.89e-02 1.06e-01 0.18500 -0.173000 0.063400 3.07e-02 4.29e-01
SARS-CoV Infections 121 1.80e-03 8.05e-03 0.18500 -0.001960 0.185000 9.70e-01 4.68e-04
Apoptosis 135 5.16e-04 2.75e-03 0.18400 -0.047500 0.178000 3.43e-01 3.69e-04
Biological oxidations 85 2.50e-02 6.67e-02 0.18400 -0.141000 -0.118000 2.49e-02 5.95e-02
Autodegradation of Cdh1 by Cdh1:APC/C 58 7.33e-02 1.42e-01 0.18400 0.082100 0.165000 2.80e-01 3.03e-02
Transmission across Chemical Synapses 124 1.91e-03 8.40e-03 0.18400 -0.183000 -0.011400 4.33e-04 8.27e-01
Programmed Cell Death 145 3.03e-04 1.71e-03 0.18300 -0.052200 0.176000 2.80e-01 2.71e-04
FCERI mediated NF-kB activation 65 4.63e-02 1.03e-01 0.18300 0.045300 0.177000 5.29e-01 1.36e-02
AKT phosphorylates targets in the cytosol 14 4.34e-01 5.45e-01 0.18300 -0.148000 0.108000 3.39e-01 4.86e-01
Signaling by NOTCH4 70 3.28e-02 7.93e-02 0.18300 0.025100 0.181000 7.17e-01 8.96e-03
Constitutive Signaling by AKT1 E17K in Cancer 26 2.94e-01 4.11e-01 0.18300 -0.177000 -0.046200 1.19e-01 6.84e-01
Activation of the AP-1 family of transcription factors 10 5.96e-01 6.89e-01 0.18200 -0.007420 0.182000 9.68e-01 3.19e-01
Asymmetric localization of PCP proteins 55 7.63e-02 1.46e-01 0.18200 0.044200 0.176000 5.72e-01 2.38e-02
G2/M Transition 153 1.58e-03 7.23e-03 0.18200 0.144000 0.111000 2.17e-03 1.84e-02
Signaling by VEGF 83 7.50e-03 2.59e-02 0.18200 -0.120000 0.136000 5.87e-02 3.23e-02
Activation of NMDA receptors and postsynaptic events 52 6.44e-02 1.27e-01 0.18200 -0.180000 0.022700 2.48e-02 7.78e-01
Acyl chain remodelling of PE 11 5.57e-01 6.55e-01 0.18100 0.179000 -0.028000 3.04e-01 8.72e-01
Signaling by FGFR1 34 2.30e-01 3.46e-01 0.18100 0.089000 0.158000 3.70e-01 1.12e-01
Metabolic disorders of biological oxidation enzymes 13 5.06e-01 6.09e-01 0.18100 -0.180000 0.020600 2.62e-01 8.98e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 14 5.29e-01 6.29e-01 0.18100 0.172000 0.054300 2.65e-01 7.25e-01
Downstream signaling events of B Cell Receptor (BCR) 67 3.34e-02 8.04e-02 0.18000 -0.009050 0.180000 8.98e-01 1.09e-02
Gene expression (Transcription) 997 4.16e-18 4.67e-16 0.18000 0.166000 0.070600 4.98e-18 2.37e-04
Signaling by Rho GTPases 269 1.99e-06 2.21e-05 0.18000 0.000260 0.180000 9.94e-01 4.35e-07
Activated NTRK2 signals through FRS2 and FRS3 10 6.34e-01 7.17e-01 0.18000 0.047400 0.174000 7.95e-01 3.42e-01
GLI3 is processed to GLI3R by the proteasome 50 1.04e-01 1.85e-01 0.18000 0.049000 0.173000 5.50e-01 3.45e-02
Hemostasis 349 3.13e-09 8.04e-08 0.18000 -0.141000 0.111000 7.12e-06 3.96e-04
Regulation of PTEN stability and activity 59 8.82e-02 1.62e-01 0.17900 0.107000 0.143000 1.54e-01 5.81e-02
G alpha (s) signalling events 51 1.14e-01 1.99e-01 0.17800 -0.161000 -0.076400 4.66e-02 3.46e-01
Dopamine Neurotransmitter Release Cycle 11 5.75e-01 6.69e-01 0.17800 -0.015100 0.178000 9.31e-01 3.08e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 21 3.57e-01 4.72e-01 0.17800 -0.178000 0.003170 1.58e-01 9.80e-01
O-linked glycosylation 51 6.16e-02 1.24e-01 0.17800 -0.163000 0.072300 4.49e-02 3.72e-01
Signaling by EGFR in Cancer 18 4.80e-01 5.87e-01 0.17800 0.112000 0.138000 4.13e-01 3.09e-01
Mitotic G2-G2/M phases 155 2.02e-03 8.82e-03 0.17700 0.137000 0.113000 3.44e-03 1.54e-02
Signalling to ERKs 29 2.12e-01 3.22e-01 0.17700 -0.059000 0.167000 5.82e-01 1.19e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 3.73e-01 4.87e-01 0.17700 0.171000 -0.042700 1.96e-01 7.47e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 3.73e-01 4.87e-01 0.17700 0.171000 -0.042700 1.96e-01 7.47e-01
Formation of Incision Complex in GG-NER 39 1.37e-01 2.29e-01 0.17700 0.173000 -0.034100 6.14e-02 7.13e-01
Signal transduction by L1 20 3.27e-01 4.42e-01 0.17600 -0.130000 0.119000 3.13e-01 3.58e-01
Miscellaneous transport and binding events 16 4.15e-01 5.27e-01 0.17600 0.150000 -0.092500 2.99e-01 5.22e-01
Purine catabolism 14 5.74e-01 6.69e-01 0.17600 -0.119000 -0.130000 4.42e-01 4.02e-01
Death Receptor Signalling 106 4.69e-03 1.77e-02 0.17600 -0.171000 0.039000 2.36e-03 4.90e-01
SLC transporter disorders 51 1.33e-01 2.25e-01 0.17500 0.103000 0.141000 2.03e-01 8.12e-02
CLEC7A (Dectin-1) signaling 80 2.10e-02 5.90e-02 0.17500 -0.018200 0.174000 7.78e-01 7.36e-03
Recycling pathway of L1 23 3.14e-01 4.31e-01 0.17400 -0.041700 0.169000 7.29e-01 1.60e-01
Platelet activation, signaling and aggregation 169 1.29e-04 8.35e-04 0.17400 -0.093600 0.147000 3.65e-02 1.05e-03
RHO GTPases Activate NADPH Oxidases 13 5.12e-01 6.14e-01 0.17400 -0.059500 0.163000 7.10e-01 3.09e-01
Uptake and actions of bacterial toxins 21 3.23e-01 4.39e-01 0.17300 -0.127000 0.118000 3.15e-01 3.51e-01
Interleukin-7 signaling 12 6.01e-01 6.92e-01 0.17300 -0.168000 -0.042700 3.15e-01 7.98e-01
Nucleobase catabolism 21 4.41e-01 5.52e-01 0.17300 -0.146000 -0.091800 2.47e-01 4.66e-01
Innate Immune System 608 4.07e-13 2.39e-11 0.17300 -0.043100 0.167000 7.38e-02 4.06e-12
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 29 2.52e-01 3.69e-01 0.17200 0.021200 -0.171000 8.44e-01 1.11e-01
Regulation of PTEN gene transcription 58 9.05e-02 1.65e-01 0.17200 0.048500 0.165000 5.24e-01 2.97e-02
activated TAK1 mediates p38 MAPK activation 17 4.48e-01 5.60e-01 0.17200 -0.171000 0.019300 2.23e-01 8.90e-01
Mismatch Repair 14 5.09e-01 6.11e-01 0.17200 0.169000 -0.031200 2.74e-01 8.40e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 16 5.12e-01 6.14e-01 0.17100 0.040600 0.167000 7.79e-01 2.49e-01
GPCR ligand binding 74 3.00e-02 7.52e-02 0.17100 -0.169000 0.029100 1.23e-02 6.66e-01
Arachidonic acid metabolism 19 4.77e-01 5.85e-01 0.17100 -0.153000 -0.074700 2.47e-01 5.73e-01
Cytochrome c-mediated apoptotic response 10 6.35e-01 7.17e-01 0.17000 -0.010300 0.170000 9.55e-01 3.53e-01
DNA Damage Recognition in GG-NER 34 2.26e-01 3.42e-01 0.17000 0.170000 0.008360 8.69e-02 9.33e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 23 3.94e-01 5.07e-01 0.17000 0.045800 0.163000 7.04e-01 1.75e-01
TRAF6 mediated NF-kB activation 19 3.79e-01 4.91e-01 0.16900 -0.134000 0.103000 3.11e-01 4.38e-01
Mitochondrial iron-sulfur cluster biogenesis 12 6.33e-01 7.17e-01 0.16900 -0.074800 -0.151000 6.54e-01 3.64e-01
Activation of HOX genes during differentiation 50 1.47e-01 2.41e-01 0.16900 0.154000 0.068300 5.95e-02 4.04e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 50 1.47e-01 2.41e-01 0.16900 0.154000 0.068300 5.95e-02 4.04e-01
Negative regulation of MAPK pathway 39 2.20e-01 3.33e-01 0.16800 0.057900 0.158000 5.32e-01 8.79e-02
Hyaluronan metabolism 11 5.81e-01 6.75e-01 0.16800 -0.072400 0.152000 6.78e-01 3.83e-01
ESR-mediated signaling 126 9.33e-03 3.13e-02 0.16800 0.148000 0.080900 4.34e-03 1.18e-01
Dual Incision in GG-NER 38 2.28e-01 3.43e-01 0.16800 0.159000 0.056000 9.10e-02 5.51e-01
Endogenous sterols 13 6.01e-01 6.92e-01 0.16800 -0.054300 -0.159000 7.35e-01 3.21e-01
Degradation of GLI1 by the proteasome 51 1.42e-01 2.35e-01 0.16800 0.062000 0.156000 4.44e-01 5.42e-02
Depolymerisation of the Nuclear Lamina 13 6.23e-01 7.08e-01 0.16700 0.091300 0.140000 5.69e-01 3.82e-01
G beta:gamma signalling through PLC beta 12 6.51e-01 7.30e-01 0.16700 -0.119000 -0.117000 4.75e-01 4.83e-01
Presynaptic function of Kainate receptors 12 6.51e-01 7.30e-01 0.16700 -0.119000 -0.117000 4.75e-01 4.83e-01
APC/C:Cdc20 mediated degradation of Securin 59 1.24e-01 2.13e-01 0.16600 0.107000 0.127000 1.54e-01 9.24e-02
FRS-mediated FGFR2 signaling 12 5.68e-01 6.65e-01 0.16600 -0.058600 0.155000 7.25e-01 3.52e-01
Carboxyterminal post-translational modifications of tubulin 21 3.70e-01 4.83e-01 0.16600 -0.153000 0.063500 2.24e-01 6.14e-01
MicroRNA (miRNA) biogenesis 22 3.69e-01 4.82e-01 0.16500 0.161000 -0.038500 1.92e-01 7.55e-01
MTOR signalling 40 2.36e-01 3.52e-01 0.16500 -0.079200 -0.145000 3.86e-01 1.12e-01
Base Excision Repair 43 2.27e-01 3.42e-01 0.16400 0.109000 0.122000 2.15e-01 1.65e-01
p75 NTR receptor-mediated signalling 73 3.63e-02 8.51e-02 0.16400 -0.155000 0.053600 2.24e-02 4.29e-01
Signaling by Receptor Tyrosine Kinases 357 1.77e-07 2.51e-06 0.16400 -0.046200 0.157000 1.37e-01 4.42e-07
Negative regulation of the PI3K/AKT network 69 6.44e-02 1.27e-01 0.16400 0.014800 0.163000 8.32e-01 1.95e-02
Disorders of Developmental Biology 10 6.85e-01 7.56e-01 0.16300 -0.041200 -0.158000 8.21e-01 3.87e-01
Disorders of Nervous System Development 10 6.85e-01 7.56e-01 0.16300 -0.041200 -0.158000 8.21e-01 3.87e-01
Loss of function of MECP2 in Rett syndrome 10 6.85e-01 7.56e-01 0.16300 -0.041200 -0.158000 8.21e-01 3.87e-01
Pervasive developmental disorders 10 6.85e-01 7.56e-01 0.16300 -0.041200 -0.158000 8.21e-01 3.87e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 62 7.70e-02 1.47e-01 0.16300 -0.005260 0.163000 9.43e-01 2.64e-02
FOXO-mediated transcription of cell cycle genes 16 5.19e-01 6.19e-01 0.16300 -0.163000 -0.000376 2.58e-01 9.98e-01
APC/C:Cdc20 mediated degradation of Cyclin B 20 4.41e-01 5.52e-01 0.16300 0.163000 0.000931 2.07e-01 9.94e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 30 2.74e-01 3.95e-01 0.16300 0.161000 -0.026600 1.28e-01 8.01e-01
DAP12 interactions 15 5.60e-01 6.55e-01 0.16300 0.026200 0.161000 8.60e-01 2.81e-01
DAP12 signaling 15 5.60e-01 6.55e-01 0.16300 0.026200 0.161000 8.60e-01 2.81e-01
PKMTs methylate histone lysines 37 1.88e-01 2.92e-01 0.16300 0.152000 -0.057200 1.09e-01 5.47e-01
Tie2 Signaling 13 6.13e-01 6.99e-01 0.16200 0.158000 0.036400 3.24e-01 8.20e-01
Energy dependent regulation of mTOR by LKB1-AMPK 29 3.65e-01 4.79e-01 0.16200 -0.077500 -0.142000 4.70e-01 1.85e-01
Intraflagellar transport 35 1.93e-01 2.98e-01 0.16200 0.122000 -0.107000 2.13e-01 2.74e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 34 3.19e-01 4.36e-01 0.16200 0.112000 0.117000 2.58e-01 2.40e-01
Insulin receptor recycling 17 5.18e-01 6.19e-01 0.16200 0.018100 0.161000 8.97e-01 2.52e-01
Mitophagy 24 3.34e-01 4.49e-01 0.16000 0.134000 -0.087800 2.56e-01 4.57e-01
Metabolism of carbohydrates 205 1.85e-04 1.14e-03 0.16000 -0.154000 0.041500 1.49e-04 3.09e-01
RNA Polymerase III Transcription Termination 22 4.53e-01 5.64e-01 0.15900 0.154000 0.040200 2.11e-01 7.45e-01
FOXO-mediated transcription 51 1.90e-01 2.95e-01 0.15900 -0.121000 -0.103000 1.35e-01 2.02e-01
Regulated proteolysis of p75NTR 11 6.83e-01 7.56e-01 0.15900 0.058300 0.148000 7.38e-01 3.95e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 13 6.02e-01 6.92e-01 0.15900 -0.002050 0.159000 9.90e-01 3.21e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 25 4.23e-01 5.34e-01 0.15900 0.056500 0.148000 6.25e-01 2.00e-01
DCC mediated attractive signaling 13 5.95e-01 6.89e-01 0.15800 -0.157000 0.018300 3.28e-01 9.09e-01
Signaling by NTRK3 (TRKC) 16 5.22e-01 6.23e-01 0.15800 -0.155000 0.027600 2.82e-01 8.49e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 24 4.51e-01 5.62e-01 0.15700 -0.143000 -0.065600 2.26e-01 5.78e-01
Anti-inflammatory response favouring Leishmania parasite infection 56 1.18e-01 2.05e-01 0.15600 -0.156000 0.007930 4.35e-02 9.18e-01
Leishmania parasite growth and survival 56 1.18e-01 2.05e-01 0.15600 -0.156000 0.007930 4.35e-02 9.18e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 20 5.37e-01 6.36e-01 0.15600 -0.104000 -0.116000 4.22e-01 3.69e-01
Metabolism of nucleotides 74 7.88e-02 1.49e-01 0.15600 -0.151000 -0.035600 2.45e-02 5.97e-01
Regulation of FZD by ubiquitination 11 6.20e-01 7.05e-01 0.15600 -0.101000 0.118000 5.61e-01 4.98e-01
Transport of small molecules 410 3.29e-06 3.38e-05 0.15500 -0.136000 -0.075700 2.99e-06 9.20e-03
Diseases of glycosylation 97 1.58e-02 4.81e-02 0.15500 -0.110000 0.109000 6.25e-02 6.37e-02
Ca2+ pathway 45 2.07e-01 3.17e-01 0.15500 -0.022700 -0.153000 7.92e-01 7.62e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 6.62e-01 7.40e-01 0.15500 0.031400 0.151000 8.50e-01 3.64e-01
Resolution of Abasic Sites (AP sites) 36 3.26e-01 4.42e-01 0.15400 0.082900 0.130000 3.90e-01 1.76e-01
L1CAM interactions 70 5.85e-02 1.19e-01 0.15400 -0.145000 0.054100 3.68e-02 4.34e-01
DNA Double Strand Break Response 37 3.23e-01 4.39e-01 0.15400 0.110000 0.108000 2.47e-01 2.55e-01
Phosphorylation of the APC/C 18 4.77e-01 5.85e-01 0.15400 0.139000 -0.066000 3.08e-01 6.28e-01
RNA Polymerase II Transcription 889 6.76e-12 2.87e-10 0.15300 0.138000 0.066500 8.38e-12 1.00e-03
Regulation of localization of FOXO transcription factors 11 7.06e-01 7.72e-01 0.15300 -0.140000 -0.063100 4.23e-01 7.17e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 6.71e-01 7.48e-01 0.15200 -0.008090 0.152000 9.63e-01 3.84e-01
Glutamate Neurotransmitter Release Cycle 12 6.39e-01 7.20e-01 0.15100 -0.024800 0.149000 8.82e-01 3.70e-01
Signaling by the B Cell Receptor (BCR) 85 5.18e-02 1.09e-01 0.15100 0.000958 0.151000 9.88e-01 1.63e-02
Transcriptional Regulation by TP53 307 1.42e-04 9.04e-04 0.15100 0.125000 0.084300 1.81e-04 1.17e-02
Late endosomal microautophagy 23 3.95e-01 5.08e-01 0.15100 -0.127000 0.082000 2.94e-01 4.96e-01
Transcriptional regulation of white adipocyte differentiation 71 1.02e-01 1.82e-01 0.15100 0.147000 0.034600 3.29e-02 6.15e-01
MHC class II antigen presentation 71 1.26e-01 2.17e-01 0.15000 0.090400 0.120000 1.89e-01 8.03e-02
STING mediated induction of host immune responses 11 6.71e-01 7.48e-01 0.15000 0.149000 -0.020100 3.93e-01 9.08e-01
Glycogen synthesis 12 6.36e-01 7.18e-01 0.15000 -0.144000 0.040700 3.87e-01 8.07e-01
PI-3K cascade:FGFR2 10 6.67e-01 7.45e-01 0.15000 -0.108000 0.104000 5.56e-01 5.67e-01
Cargo trafficking to the periciliary membrane 42 1.96e-01 3.03e-01 0.15000 0.137000 -0.059700 1.23e-01 5.04e-01
Developmental Biology 588 2.95e-10 9.33e-09 0.15000 -0.070600 0.132000 3.97e-03 6.77e-08
MAPK6/MAPK4 signaling 73 9.85e-02 1.77e-01 0.15000 0.034600 0.146000 6.10e-01 3.17e-02
PINK1-PRKN Mediated Mitophagy 17 5.15e-01 6.16e-01 0.14900 0.133000 -0.068000 3.42e-01 6.28e-01
O-glycosylation of TSR domain-containing proteins 25 4.56e-01 5.65e-01 0.14900 -0.144000 -0.038600 2.12e-01 7.38e-01
Clathrin-mediated endocytosis 109 4.55e-02 1.01e-01 0.14900 0.098700 0.112000 7.59e-02 4.42e-02
NR1H2 and NR1H3-mediated signaling 34 3.82e-01 4.94e-01 0.14900 -0.098100 -0.112000 3.23e-01 2.61e-01
Organelle biogenesis and maintenance 224 2.31e-04 1.36e-03 0.14800 0.059500 -0.136000 1.27e-01 4.86e-04
MAPK1/MAPK3 signaling 193 6.43e-04 3.39e-03 0.14800 -0.071700 0.130000 8.73e-02 1.96e-03
PI-3K cascade:FGFR3 10 7.45e-01 8.04e-01 0.14800 0.065300 0.133000 7.21e-01 4.66e-01
Metabolism 1377 1.63e-15 1.67e-13 0.14800 -0.115000 -0.093100 4.70e-12 2.29e-08
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 6.00e-01 6.92e-01 0.14800 0.112000 -0.096400 4.84e-01 5.47e-01
Intra-Golgi traffic 38 3.37e-01 4.52e-01 0.14700 0.128000 0.073200 1.72e-01 4.35e-01
Apoptotic cleavage of cellular proteins 27 3.55e-01 4.71e-01 0.14700 -0.126000 0.075900 2.56e-01 4.95e-01
mRNA decay by 5' to 3' exoribonuclease 14 6.03e-01 6.92e-01 0.14700 0.143000 -0.035900 3.55e-01 8.16e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 19 4.79e-01 5.87e-01 0.14700 0.116000 -0.090400 3.81e-01 4.96e-01
PTEN Regulation 128 2.83e-02 7.34e-02 0.14700 0.082200 0.122000 1.09e-01 1.76e-02
RAF/MAP kinase cascade 188 8.99e-04 4.58e-03 0.14700 -0.069500 0.130000 1.02e-01 2.30e-03
Toll Like Receptor 4 (TLR4) Cascade 102 2.49e-02 6.67e-02 0.14700 -0.046700 0.139000 4.17e-01 1.55e-02
Disorders of transmembrane transporters 107 4.80e-02 1.05e-01 0.14700 0.067800 0.130000 2.27e-01 2.04e-02
CTLA4 inhibitory signaling 17 5.49e-01 6.48e-01 0.14700 -0.028100 0.144000 8.41e-01 3.04e-01
Hedgehog 'on' state 71 1.23e-01 2.12e-01 0.14700 0.048200 0.138000 4.84e-01 4.40e-02
Formation of Fibrin Clot (Clotting Cascade) 13 6.92e-01 7.62e-01 0.14600 0.073300 0.127000 6.47e-01 4.29e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 55 1.87e-01 2.91e-01 0.14600 0.031600 0.143000 6.86e-01 6.74e-02
Chromatin modifying enzymes 180 5.69e-03 2.08e-02 0.14600 0.136000 0.053000 1.71e-03 2.22e-01
Chromatin organization 180 5.69e-03 2.08e-02 0.14600 0.136000 0.053000 1.71e-03 2.22e-01
Tight junction interactions 11 7.35e-01 7.97e-01 0.14600 0.071900 0.127000 6.80e-01 4.67e-01
G alpha (q) signalling events 78 9.75e-02 1.76e-01 0.14600 -0.141000 -0.036100 3.16e-02 5.83e-01
FOXO-mediated transcription of cell death genes 14 6.76e-01 7.51e-01 0.14500 -0.128000 -0.068100 4.06e-01 6.59e-01
Gap junction trafficking and regulation 13 6.77e-01 7.51e-01 0.14500 0.033400 0.141000 8.35e-01 3.79e-01
Budding and maturation of HIV virion 22 5.28e-01 6.29e-01 0.14500 0.047300 0.137000 7.01e-01 2.66e-01
Golgi-to-ER retrograde transport 89 9.32e-02 1.69e-01 0.14500 0.099000 0.105000 1.07e-01 8.63e-02
Glucagon-type ligand receptors 11 7.44e-01 8.04e-01 0.14500 -0.096200 -0.108000 5.81e-01 5.35e-01
MyD88-independent TLR4 cascade 83 4.81e-02 1.05e-01 0.14500 -0.070600 0.126000 2.67e-01 4.74e-02
TRIF(TICAM1)-mediated TLR4 signaling 83 4.81e-02 1.05e-01 0.14500 -0.070600 0.126000 2.67e-01 4.74e-02
Translation 222 9.77e-04 4.91e-03 0.14400 0.144000 0.003970 2.27e-04 9.19e-01
Toll-like Receptor Cascades 115 2.01e-02 5.73e-02 0.14400 -0.029600 0.141000 5.84e-01 9.04e-03
Signaling by ERBB2 TMD/JMD mutants 14 5.94e-01 6.88e-01 0.14400 -0.106000 0.096800 4.91e-01 5.31e-01
ADORA2B mediated anti-inflammatory cytokines production 38 3.31e-01 4.46e-01 0.14400 -0.139000 -0.036200 1.39e-01 7.00e-01
Resolution of D-Loop Structures 21 5.72e-01 6.67e-01 0.14300 0.118000 0.081300 3.50e-01 5.19e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 21 5.72e-01 6.67e-01 0.14300 0.118000 0.081300 3.50e-01 5.19e-01
Adrenaline,noradrenaline inhibits insulin secretion 17 6.36e-01 7.18e-01 0.14300 -0.082900 -0.117000 5.54e-01 4.05e-01
Constitutive Signaling by Aberrant PI3K in Cancer 38 2.53e-01 3.70e-01 0.14300 -0.122000 0.074500 1.93e-01 4.28e-01
VEGFR2 mediated vascular permeability 23 4.34e-01 5.45e-01 0.14300 -0.078900 0.119000 5.13e-01 3.23e-01
Glycosphingolipid metabolism 32 3.10e-01 4.27e-01 0.14300 -0.108000 0.093800 2.92e-01 3.59e-01
C-type lectin receptors (CLRs) 94 4.85e-02 1.05e-01 0.14200 -0.016700 0.141000 7.81e-01 1.81e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 148 1.95e-02 5.58e-02 0.14100 0.129000 0.057200 6.87e-03 2.32e-01
Plasma lipoprotein clearance 21 4.72e-01 5.81e-01 0.14100 -0.110000 0.088600 3.83e-01 4.83e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 6.03e-01 6.92e-01 0.14100 -0.013800 0.140000 9.24e-01 3.32e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 6.03e-01 6.92e-01 0.14100 -0.013800 0.140000 9.24e-01 3.32e-01
ERKs are inactivated 13 6.32e-01 7.17e-01 0.14100 -0.081400 0.115000 6.12e-01 4.74e-01
Transcriptional regulation by RUNX1 139 2.95e-02 7.46e-02 0.14100 0.082000 0.114000 9.63e-02 2.04e-02
Signal amplification 20 5.89e-01 6.84e-01 0.14000 0.058800 0.127000 6.49e-01 3.24e-01
Costimulation by the CD28 family 39 3.00e-01 4.17e-01 0.14000 -0.009620 0.140000 9.17e-01 1.31e-01
SUMOylation of DNA methylation proteins 15 6.85e-01 7.56e-01 0.14000 0.105000 0.093200 4.83e-01 5.32e-01
Synthesis of glycosylphosphatidylinositol (GPI) 15 6.06e-01 6.93e-01 0.14000 0.131000 -0.048500 3.80e-01 7.45e-01
Oncogenic MAPK signaling 68 9.40e-02 1.70e-01 0.14000 -0.111000 0.085100 1.15e-01 2.26e-01
Rho GTPase cycle 104 2.70e-02 7.07e-02 0.14000 -0.107000 0.089900 6.03e-02 1.14e-01
Signaling by KIT in disease 17 6.06e-01 6.93e-01 0.13900 -0.139000 -0.004910 3.21e-01 9.72e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 17 6.06e-01 6.93e-01 0.13900 -0.139000 -0.004910 3.21e-01 9.72e-01
RET signaling 28 4.21e-01 5.32e-01 0.13900 -0.138000 0.017000 2.07e-01 8.77e-01
Interconversion of nucleotide di- and triphosphates 21 4.84e-01 5.89e-01 0.13900 -0.096500 0.099700 4.44e-01 4.29e-01
Transcriptional regulation by RUNX2 99 5.53e-02 1.14e-01 0.13800 -0.002400 0.138000 9.67e-01 1.80e-02
PI3K/AKT Signaling in Cancer 65 1.31e-01 2.23e-01 0.13800 -0.134000 0.033100 6.31e-02 6.45e-01
RUNX3 regulates NOTCH signaling 13 7.31e-01 7.95e-01 0.13600 0.080200 0.110000 6.17e-01 4.92e-01
PIP3 activates AKT signaling 212 5.01e-03 1.86e-02 0.13600 0.044500 0.128000 2.66e-01 1.36e-03
TBC/RABGAPs 39 3.82e-01 4.94e-01 0.13600 0.056800 0.123000 5.40e-01 1.83e-01
Signaling by SCF-KIT 32 3.68e-01 4.82e-01 0.13600 -0.044100 0.128000 6.66e-01 2.10e-01
Signaling by ERBB2 37 3.01e-01 4.17e-01 0.13600 -0.070900 0.116000 4.56e-01 2.24e-01
Signaling by EGFR 41 3.53e-01 4.70e-01 0.13600 0.043400 0.128000 6.31e-01 1.55e-01
Synthesis of PC 21 6.10e-01 6.96e-01 0.13500 -0.095500 -0.096100 4.49e-01 4.46e-01
Regulation of insulin secretion 47 2.94e-01 4.11e-01 0.13500 -0.132000 -0.030200 1.19e-01 7.20e-01
SHC-mediated cascade:FGFR4 10 7.22e-01 7.86e-01 0.13500 -0.089000 0.101000 6.26e-01 5.81e-01
Disease 1013 1.15e-11 4.71e-10 0.13500 0.007550 0.134000 6.92e-01 1.74e-12
Immune System 1225 1.08e-14 8.90e-13 0.13500 -0.024100 0.132000 1.69e-01 4.10e-14
Circadian Clock 63 2.33e-01 3.49e-01 0.13400 -0.092300 -0.097800 2.06e-01 1.80e-01
Amino acids regulate mTORC1 45 2.59e-01 3.76e-01 0.13300 -0.044700 0.125000 6.04e-01 1.47e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 24 5.80e-01 6.74e-01 0.13300 0.080700 0.105000 4.94e-01 3.72e-01
Ub-specific processing proteases 145 3.92e-02 9.04e-02 0.13300 0.098800 0.088500 4.06e-02 6.69e-02
Cell-cell junction organization 23 4.91e-01 5.96e-01 0.13100 -0.093800 0.091800 4.36e-01 4.46e-01
MAPK family signaling cascades 224 1.25e-03 5.97e-03 0.13100 -0.066700 0.113000 8.70e-02 3.75e-03
Toll Like Receptor 3 (TLR3) Cascade 82 8.45e-02 1.57e-01 0.13100 -0.071700 0.109000 2.63e-01 8.80e-02
NRIF signals cell death from the nucleus 13 7.50e-01 8.07e-01 0.13000 0.075400 0.106000 6.38e-01 5.06e-01
Phase II - Conjugation of compounds 46 3.61e-01 4.76e-01 0.13000 -0.067500 -0.111000 4.29e-01 1.93e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 25 5.75e-01 6.69e-01 0.12900 0.114000 0.062100 3.26e-01 5.91e-01
Aggrephagy 16 6.93e-01 7.63e-01 0.12900 0.046900 0.121000 7.45e-01 4.04e-01
Glutathione synthesis and recycling 10 7.47e-01 8.05e-01 0.12900 -0.061800 0.113000 7.35e-01 5.36e-01
FLT3 Signaling 199 3.18e-03 1.29e-02 0.12900 -0.068700 0.109000 9.63e-02 8.40e-03
Cellular Senescence 117 8.36e-02 1.56e-01 0.12900 0.075000 0.104000 1.63e-01 5.18e-02
Growth hormone receptor signaling 17 6.05e-01 6.93e-01 0.12800 -0.083600 0.097300 5.51e-01 4.87e-01
Regulation of PLK1 Activity at G2/M Transition 74 1.76e-01 2.78e-01 0.12800 0.125000 0.024400 6.24e-02 7.17e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 4.83e-01 5.89e-01 0.12800 -0.125000 -0.024700 2.28e-01 8.12e-01
Oncogene Induced Senescence 29 5.35e-01 6.34e-01 0.12700 0.113000 0.058800 2.92e-01 5.84e-01
Asparagine N-linked glycosylation 237 6.80e-03 2.41e-02 0.12700 0.055700 0.114000 1.42e-01 2.67e-03
Signaling by cytosolic FGFR1 fusion mutants 17 6.59e-01 7.38e-01 0.12700 -0.003780 -0.127000 9.79e-01 3.66e-01
Diseases of metabolism 154 2.51e-02 6.68e-02 0.12700 -0.126000 -0.007630 6.97e-03 8.71e-01
Signaling by FGFR4 29 5.27e-01 6.28e-01 0.12600 0.040300 0.120000 7.07e-01 2.65e-01
Cargo recognition for clathrin-mediated endocytosis 73 2.10e-01 3.20e-01 0.12600 0.116000 0.050700 8.84e-02 4.54e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 36 4.83e-01 5.89e-01 0.12600 0.085300 0.092200 3.76e-01 3.39e-01
VxPx cargo-targeting to cilium 17 6.92e-01 7.62e-01 0.12500 -0.041500 -0.118000 7.67e-01 3.99e-01
Downstream signaling of activated FGFR3 17 7.11e-01 7.75e-01 0.12500 0.092900 0.083700 5.07e-01 5.50e-01
Downregulation of ERBB2 signaling 18 6.33e-01 7.17e-01 0.12400 -0.027100 0.121000 8.43e-01 3.74e-01
Platelet homeostasis 51 3.24e-01 4.39e-01 0.12400 -0.122000 -0.023800 1.33e-01 7.69e-01
ABC transporter disorders 56 3.03e-01 4.19e-01 0.12400 0.034800 0.119000 6.52e-01 1.25e-01
Inactivation, recovery and regulation of the phototransduction cascade 13 7.03e-01 7.72e-01 0.12300 -0.102000 0.069900 5.26e-01 6.63e-01
The phototransduction cascade 13 7.03e-01 7.72e-01 0.12300 -0.102000 0.069900 5.26e-01 6.63e-01
Signaling by TGFB family members 86 1.71e-01 2.72e-01 0.12300 0.047000 0.114000 4.52e-01 6.82e-02
TNF signaling 34 4.55e-01 5.65e-01 0.12300 -0.123000 -0.000908 2.15e-01 9.93e-01
Protein methylation 10 7.90e-01 8.44e-01 0.12300 -0.004400 0.123000 9.81e-01 5.02e-01
AURKA Activation by TPX2 62 2.60e-01 3.77e-01 0.12300 0.121000 0.022800 1.01e-01 7.57e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 27 5.91e-01 6.86e-01 0.12200 -0.100000 -0.070000 3.66e-01 5.30e-01
Anchoring of the basal body to the plasma membrane 83 1.62e-01 2.62e-01 0.12200 0.121000 0.016300 5.66e-02 7.98e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 66 1.92e-01 2.98e-01 0.12200 -0.037900 0.116000 5.95e-01 1.05e-01
Factors involved in megakaryocyte development and platelet production 80 1.38e-01 2.31e-01 0.12100 -0.114000 0.040100 7.82e-02 5.36e-01
Signal Transduction 1401 1.83e-14 1.41e-12 0.12100 -0.064200 0.102000 1.03e-04 6.07e-10
Cellular response to hypoxia 62 2.84e-01 4.02e-01 0.12100 0.034500 0.116000 6.39e-01 1.15e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 6.38e-01 7.20e-01 0.12100 0.121000 -0.000141 3.50e-01 9.99e-01
Cilium Assembly 158 2.18e-02 6.09e-02 0.12000 0.114000 -0.038700 1.39e-02 4.03e-01
Fc epsilon receptor (FCERI) signaling 104 1.13e-01 1.98e-01 0.12000 0.015100 0.119000 7.91e-01 3.68e-02
G beta:gamma signalling through BTK 10 8.26e-01 8.70e-01 0.12000 -0.052000 -0.108000 7.76e-01 5.56e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 7.69e-01 8.23e-01 0.11800 0.116000 0.021300 4.69e-01 8.94e-01
Oxidative Stress Induced Senescence 59 3.46e-01 4.62e-01 0.11800 0.068800 0.095800 3.61e-01 2.04e-01
Signaling by NOTCH3 38 4.21e-01 5.32e-01 0.11800 -0.116000 0.023200 2.18e-01 8.05e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 28 6.09e-01 6.96e-01 0.11700 -0.084100 -0.082100 4.42e-01 4.53e-01
TRAF3-dependent IRF activation pathway 12 7.64e-01 8.20e-01 0.11600 -0.114000 0.025200 4.95e-01 8.80e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 17 7.44e-01 8.04e-01 0.11600 0.076200 0.087800 5.86e-01 5.31e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 17 7.44e-01 8.04e-01 0.11600 0.076200 0.087800 5.86e-01 5.31e-01
Acyl chain remodelling of PC 12 7.62e-01 8.18e-01 0.11600 0.111000 -0.032700 5.05e-01 8.44e-01
Deubiquitination 212 2.89e-02 7.41e-02 0.11500 0.084500 0.078300 3.49e-02 5.07e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF) 53 4.07e-01 5.20e-01 0.11500 -0.089500 -0.072000 2.61e-01 3.65e-01
Fatty acyl-CoA biosynthesis 18 6.59e-01 7.38e-01 0.11400 -0.062100 0.095900 6.49e-01 4.81e-01
RMTs methylate histone arginines 28 5.34e-01 6.33e-01 0.11400 -0.103000 0.048100 3.46e-01 6.59e-01
Regulation of TP53 Activity through Association with Co-factors 12 7.97e-01 8.47e-01 0.11400 0.017600 0.112000 9.16e-01 5.01e-01
Regulation of RUNX2 expression and activity 61 3.46e-01 4.62e-01 0.11300 0.041100 0.105000 5.79e-01 1.55e-01
Apoptotic execution phase 35 4.73e-01 5.81e-01 0.11200 -0.039600 0.105000 6.85e-01 2.84e-01
Pre-NOTCH Expression and Processing 45 3.75e-01 4.88e-01 0.11100 -0.090400 0.063800 2.94e-01 4.60e-01
Signaling by Insulin receptor 48 4.52e-01 5.63e-01 0.11000 0.041700 0.102000 6.18e-01 2.21e-01
MyD88 dependent cascade initiated on endosome 77 1.99e-01 3.06e-01 0.11000 -0.048000 0.098900 4.68e-01 1.34e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 77 1.99e-01 3.06e-01 0.11000 -0.048000 0.098900 4.68e-01 1.34e-01
Transport to the Golgi and subsequent modification 136 1.28e-01 2.19e-01 0.10900 0.066600 0.085900 1.81e-01 8.46e-02
NOTCH4 Intracellular Domain Regulates Transcription 15 7.66e-01 8.21e-01 0.10800 0.001610 0.108000 9.91e-01 4.71e-01
Signaling by FGFR4 in disease 11 8.42e-01 8.86e-01 0.10800 -0.042900 -0.098700 8.06e-01 5.71e-01
Macroautophagy 98 1.37e-01 2.29e-01 0.10700 0.076300 -0.074500 1.93e-01 2.03e-01
Regulation of lipid metabolism by PPARalpha 103 1.31e-01 2.23e-01 0.10700 0.094700 -0.048800 9.76e-02 3.93e-01
WNT ligand biogenesis and trafficking 12 8.25e-01 8.70e-01 0.10600 -0.103000 -0.025900 5.37e-01 8.77e-01
Signaling by FGFR in disease 47 5.08e-01 6.11e-01 0.10600 0.078800 0.070900 3.50e-01 4.01e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 19 7.42e-01 8.04e-01 0.10600 -0.101000 -0.030600 4.44e-01 8.17e-01
Interleukin-17 signaling 62 3.17e-01 4.34e-01 0.10600 -0.102000 0.026600 1.64e-01 7.18e-01
PI-3K cascade:FGFR4 10 8.46e-01 8.87e-01 0.10500 -0.105000 -0.007870 5.65e-01 9.66e-01
Cytosolic sulfonation of small molecules 11 8.15e-01 8.62e-01 0.10500 0.029400 -0.101000 8.66e-01 5.62e-01
Signaling by FGFR1 in disease 30 5.96e-01 6.89e-01 0.10400 0.012000 -0.103000 9.09e-01 3.28e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 76 2.39e-01 3.55e-01 0.10400 -0.051300 0.090100 4.40e-01 1.75e-01
PPARA activates gene expression 101 1.50e-01 2.45e-01 0.10300 0.087100 -0.055500 1.31e-01 3.36e-01
NOD1/2 Signaling Pathway 27 6.19e-01 7.04e-01 0.10300 -0.097900 0.030900 3.79e-01 7.81e-01
TCF dependent signaling in response to WNT 134 1.47e-01 2.41e-01 0.10200 0.032400 0.096900 5.19e-01 5.36e-02
Pre-NOTCH Transcription and Translation 31 6.41e-01 7.21e-01 0.10200 0.034000 0.096200 7.43e-01 3.54e-01
CD209 (DC-SIGN) signaling 17 7.33e-01 7.96e-01 0.10200 -0.048700 0.089600 7.28e-01 5.22e-01
Prostacyclin signalling through prostacyclin receptor 12 8.48e-01 8.88e-01 0.10200 -0.089200 -0.049000 5.93e-01 7.69e-01
Signaling by ERBB2 in Cancer 18 7.43e-01 8.04e-01 0.10200 -0.012200 0.101000 9.28e-01 4.59e-01
Metabolism of proteins 1402 8.94e-08 1.51e-06 0.10200 0.078400 0.064600 2.12e-06 9.45e-05
SHC-mediated cascade:FGFR1 10 8.45e-01 8.87e-01 0.10200 -0.017400 0.100000 9.24e-01 5.84e-01
Loss of Nlp from mitotic centrosomes 60 4.09e-01 5.21e-01 0.10100 0.099900 0.014800 1.81e-01 8.43e-01
Loss of proteins required for interphase microtubule organization from the centrosome 60 4.09e-01 5.21e-01 0.10100 0.099900 0.014800 1.81e-01 8.43e-01
Glycolysis 55 4.12e-01 5.24e-01 0.10100 0.101000 -0.009580 1.98e-01 9.02e-01
ER to Golgi Anterograde Transport 114 2.20e-01 3.34e-01 0.09970 0.090800 0.041400 9.51e-02 4.47e-01
Transcriptional Regulation by VENTX 34 5.48e-01 6.47e-01 0.09930 0.072400 -0.068000 4.65e-01 4.93e-01
PI Metabolism 69 4.04e-01 5.17e-01 0.09900 0.090200 0.040800 1.96e-01 5.58e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 14 8.35e-01 8.79e-01 0.09870 0.047600 0.086500 7.58e-01 5.75e-01
Generic Transcription Pathway 780 6.74e-05 4.72e-04 0.09870 0.091400 0.037200 2.06e-05 8.31e-02
Intracellular signaling by second messengers 244 2.41e-02 6.50e-02 0.09860 -0.012000 0.097900 7.48e-01 8.83e-03
CD28 co-stimulation 25 6.49e-01 7.29e-01 0.09830 -0.060300 0.077600 6.02e-01 5.02e-01
Regulation of beta-cell development 17 7.53e-01 8.09e-01 0.09780 -0.087000 0.044500 5.35e-01 7.51e-01
Regulation of RUNX1 Expression and Activity 17 7.48e-01 8.05e-01 0.09770 0.063400 -0.074300 6.51e-01 5.96e-01
TP53 Regulates Metabolic Genes 79 3.83e-01 4.95e-01 0.09760 -0.068700 -0.069300 2.92e-01 2.88e-01
Synthesis of very long-chain fatty acyl-CoAs 10 8.65e-01 9.01e-01 0.09760 0.002870 0.097500 9.87e-01 5.93e-01
MyD88 cascade initiated on plasma membrane 75 2.80e-01 4.01e-01 0.09740 -0.067600 0.070100 3.12e-01 2.95e-01
Toll Like Receptor 10 (TLR10) Cascade 75 2.80e-01 4.01e-01 0.09740 -0.067600 0.070100 3.12e-01 2.95e-01
Toll Like Receptor 5 (TLR5) Cascade 75 2.80e-01 4.01e-01 0.09740 -0.067600 0.070100 3.12e-01 2.95e-01
Synthesis of PIPs at the plasma membrane 44 5.49e-01 6.48e-01 0.09670 0.095500 0.014900 2.73e-01 8.64e-01
Signaling by NOTCH 149 8.50e-02 1.57e-01 0.09660 -0.063900 0.072400 1.79e-01 1.29e-01
Metabolism of lipids 494 3.98e-03 1.54e-02 0.09550 -0.067100 -0.067900 1.16e-02 1.06e-02
Selective autophagy 51 4.54e-01 5.64e-01 0.09540 0.033000 -0.089500 6.84e-01 2.69e-01
Downstream signaling of activated FGFR1 19 7.93e-01 8.45e-01 0.09470 0.035200 0.087900 7.91e-01 5.07e-01
HDACs deacetylate histones 30 6.69e-01 7.46e-01 0.09450 0.094300 0.006880 3.72e-01 9.48e-01
Diseases associated with glycosylation precursor biosynthesis 18 8.03e-01 8.50e-01 0.09450 0.035100 0.087700 7.96e-01 5.20e-01
MAP kinase activation 59 4.18e-01 5.30e-01 0.09440 -0.091500 0.023400 2.25e-01 7.56e-01
G-protein beta:gamma signalling 20 7.95e-01 8.47e-01 0.09410 -0.076400 -0.054800 5.54e-01 6.71e-01
Centrosome maturation 71 3.64e-01 4.79e-01 0.09340 0.091400 -0.018800 1.84e-01 7.85e-01
Recruitment of mitotic centrosome proteins and complexes 71 3.64e-01 4.79e-01 0.09340 0.091400 -0.018800 1.84e-01 7.85e-01
Insulin processing 19 7.61e-01 8.17e-01 0.09310 0.090200 -0.022800 4.96e-01 8.63e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 35 6.77e-01 7.51e-01 0.09300 0.074300 0.056000 4.47e-01 5.67e-01
Diseases of mitotic cell cycle 35 6.77e-01 7.51e-01 0.09300 0.074300 0.056000 4.47e-01 5.67e-01
G beta:gamma signalling through CDC42 13 8.50e-01 8.89e-01 0.09270 -0.016200 -0.091300 9.20e-01 5.69e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 6.75e-01 7.51e-01 0.09220 0.060100 0.069900 5.33e-01 4.68e-01
RA biosynthesis pathway 11 8.48e-01 8.88e-01 0.09140 -0.068000 0.061000 6.96e-01 7.26e-01
Toll Like Receptor 9 (TLR9) Cascade 80 3.38e-01 4.53e-01 0.09030 -0.023600 0.087200 7.16e-01 1.79e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 81 3.20e-01 4.36e-01 0.08890 -0.054900 0.069900 3.94e-01 2.78e-01
Toll Like Receptor 2 (TLR2) Cascade 81 3.20e-01 4.36e-01 0.08890 -0.054900 0.069900 3.94e-01 2.78e-01
Toll Like Receptor TLR1:TLR2 Cascade 81 3.20e-01 4.36e-01 0.08890 -0.054900 0.069900 3.94e-01 2.78e-01
Toll Like Receptor TLR6:TLR2 Cascade 81 3.20e-01 4.36e-01 0.08890 -0.054900 0.069900 3.94e-01 2.78e-01
NOTCH1 Intracellular Domain Regulates Transcription 42 5.59e-01 6.55e-01 0.08880 -0.042800 0.077800 6.31e-01 3.83e-01
SARS-CoV-1 Infection 40 5.97e-01 6.90e-01 0.08810 -0.022000 0.085300 8.10e-01 3.51e-01
Nicotinamide salvaging 12 8.90e-01 9.20e-01 0.08640 -0.069900 -0.050800 6.75e-01 7.60e-01
Signaling by Erythropoietin 19 7.97e-01 8.47e-01 0.08640 -0.085800 0.010200 5.17e-01 9.39e-01
Post-translational protein modification 1001 1.75e-04 1.09e-03 0.08610 0.059700 0.062100 1.84e-03 1.20e-03
Signaling by BMP 23 7.40e-01 8.02e-01 0.08590 -0.046600 0.072200 6.99e-01 5.49e-01
Maturation of nucleoprotein 10 8.93e-01 9.21e-01 0.08480 -0.005810 0.084600 9.75e-01 6.43e-01
FRS-mediated FGFR4 signaling 12 8.60e-01 8.97e-01 0.08360 -0.056500 0.061500 7.35e-01 7.12e-01
Cleavage of the damaged purine 10 9.12e-01 9.34e-01 0.08280 0.075700 0.033600 6.79e-01 8.54e-01
Depurination 10 9.12e-01 9.34e-01 0.08280 0.075700 0.033600 6.79e-01 8.54e-01
Recognition and association of DNA glycosylase with site containing an affected purine 10 9.12e-01 9.34e-01 0.08280 0.075700 0.033600 6.79e-01 8.54e-01
Diseases of signal transduction by growth factor receptors and second messengers 304 3.61e-02 8.49e-02 0.08130 -0.026400 0.076900 4.33e-01 2.21e-02
Metabolism of amino acids and derivatives 226 8.33e-02 1.55e-01 0.08080 -0.075100 0.029900 5.32e-02 4.41e-01
Phospholipid metabolism 150 2.78e-01 4.00e-01 0.08070 -0.038400 -0.071000 4.19e-01 1.35e-01
Kinesins 24 7.71e-01 8.24e-01 0.08030 0.077000 -0.022900 5.14e-01 8.46e-01
Signaling by ERBB2 KD Mutants 17 8.22e-01 8.69e-01 0.08020 -0.062100 0.050700 6.58e-01 7.17e-01
FGFR1 mutant receptor activation 23 8.03e-01 8.50e-01 0.07950 -0.003790 -0.079400 9.75e-01 5.10e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 16 8.72e-01 9.05e-01 0.07870 -0.074700 -0.024800 6.05e-01 8.64e-01
Recruitment of NuMA to mitotic centrosomes 70 4.84e-01 5.89e-01 0.07860 0.075000 -0.023500 2.78e-01 7.34e-01
Glucose metabolism 69 5.56e-01 6.54e-01 0.07840 -0.023400 -0.074800 7.38e-01 2.84e-01
Beta-catenin independent WNT signaling 117 3.31e-01 4.46e-01 0.07730 -0.008240 0.076900 8.78e-01 1.52e-01
Gastrin-CREB signalling pathway via PKC and MAPK 15 8.75e-01 9.05e-01 0.07610 -0.000157 0.076100 9.99e-01 6.10e-01
G beta:gamma signalling through PI3Kgamma 15 8.94e-01 9.22e-01 0.07590 -0.062000 -0.043900 6.78e-01 7.69e-01
Iron uptake and transport 43 6.45e-01 7.25e-01 0.07540 -0.049400 0.057100 5.76e-01 5.18e-01
Membrane Trafficking 486 2.73e-02 7.12e-02 0.07530 0.070200 0.027400 8.87e-03 3.07e-01
TRAF6 mediated IRF7 activation 14 9.01e-01 9.28e-01 0.07510 0.036700 0.065500 8.12e-01 6.72e-01
Hedgehog 'off' state 87 5.06e-01 6.09e-01 0.07490 0.020000 0.072100 7.47e-01 2.46e-01
Transferrin endocytosis and recycling 21 8.62e-01 8.99e-01 0.07390 0.044400 0.059100 7.25e-01 6.40e-01
Signaling by NTRK2 (TRKB) 21 8.45e-01 8.87e-01 0.07380 0.009540 0.073200 9.40e-01 5.62e-01
Adaptive Immune System 477 3.40e-02 8.18e-02 0.07330 0.024200 0.069200 3.72e-01 1.06e-02
Nuclear signaling by ERBB4 20 8.45e-01 8.87e-01 0.07300 -0.072800 0.005550 5.73e-01 9.66e-01
Metabolism of steroids 93 4.93e-01 5.98e-01 0.07250 -0.071600 -0.011700 2.34e-01 8.46e-01
NOTCH3 Intracellular Domain Regulates Transcription 18 8.52e-01 8.89e-01 0.07050 -0.045600 0.053800 7.38e-01 6.93e-01
Vesicle-mediated transport 508 4.57e-02 1.01e-01 0.06940 0.060600 0.033700 2.09e-02 1.99e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 50 7.07e-01 7.72e-01 0.06820 -0.067900 -0.005550 4.07e-01 9.46e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 50 7.07e-01 7.72e-01 0.06820 -0.067900 -0.005550 4.07e-01 9.46e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 50 7.07e-01 7.72e-01 0.06820 -0.067900 -0.005550 4.07e-01 9.46e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 50 7.07e-01 7.72e-01 0.06820 -0.067900 -0.005550 4.07e-01 9.46e-01
Signaling by NOTCH1 in Cancer 50 7.07e-01 7.72e-01 0.06820 -0.067900 -0.005550 4.07e-01 9.46e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 31 8.26e-01 8.70e-01 0.06760 0.026200 0.062300 8.01e-01 5.49e-01
TP53 Regulates Transcription of Cell Death Genes 34 7.92e-01 8.45e-01 0.06750 -0.067400 -0.004220 4.97e-01 9.66e-01
Downstream signaling of activated FGFR2 17 8.83e-01 9.13e-01 0.06750 -0.008850 0.066900 9.50e-01 6.33e-01
Thromboxane signalling through TP receptor 14 9.22e-01 9.41e-01 0.06660 0.055100 0.037400 7.21e-01 8.09e-01
Deactivation of the beta-catenin transactivating complex 32 7.85e-01 8.38e-01 0.06500 -0.044900 0.046900 6.60e-01 6.46e-01
Autophagy 108 4.54e-01 5.64e-01 0.06410 0.047100 -0.043500 3.99e-01 4.37e-01
Signaling by Hedgehog 114 4.98e-01 6.02e-01 0.06400 0.004180 0.063900 9.39e-01 2.40e-01
Insulin receptor signalling cascade 32 8.52e-01 8.89e-01 0.06230 0.037300 0.049900 7.15e-01 6.25e-01
Signaling by Nuclear Receptors 175 4.01e-01 5.15e-01 0.06220 0.058200 0.022000 1.86e-01 6.18e-01
Post-translational modification: synthesis of GPI-anchored proteins 36 8.02e-01 8.50e-01 0.06090 0.013500 -0.059400 8.89e-01 5.38e-01
FRS-mediated FGFR1 signaling 12 9.35e-01 9.50e-01 0.06090 0.003190 0.060800 9.85e-01 7.15e-01
Signaling by ERBB2 ECD mutants 15 9.08e-01 9.34e-01 0.06080 -0.055300 0.025200 7.11e-01 8.66e-01
Signaling by FGFR3 in disease 14 9.36e-01 9.50e-01 0.06010 0.049600 0.033800 7.48e-01 8.27e-01
Signaling by FGFR3 point mutants in cancer 14 9.36e-01 9.50e-01 0.06010 0.049600 0.033800 7.48e-01 8.27e-01
Cleavage of the damaged pyrimidine 14 9.35e-01 9.50e-01 0.05990 0.053600 0.026900 7.29e-01 8.62e-01
Depyrimidination 14 9.35e-01 9.50e-01 0.05990 0.053600 0.026900 7.29e-01 8.62e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 14 9.35e-01 9.50e-01 0.05990 0.053600 0.026900 7.29e-01 8.62e-01
Signaling by WNT 202 3.77e-01 4.90e-01 0.05890 0.014600 0.057000 7.22e-01 1.64e-01
RUNX2 regulates osteoblast differentiation 20 9.16e-01 9.36e-01 0.05860 -0.041200 -0.041800 7.50e-01 7.47e-01
Extra-nuclear estrogen signaling 53 7.98e-01 8.47e-01 0.05770 0.041600 0.040000 6.01e-01 6.15e-01
CD28 dependent PI3K/Akt signaling 17 9.16e-01 9.36e-01 0.05640 -0.055600 0.009720 6.92e-01 9.45e-01
Signaling by NOTCH2 24 9.08e-01 9.34e-01 0.05500 -0.026100 -0.048400 8.25e-01 6.82e-01
RAF activation 34 8.69e-01 9.04e-01 0.05450 -0.016700 -0.051900 8.66e-01 6.01e-01
Signaling by NOTCH1 63 7.20e-01 7.84e-01 0.05430 -0.044900 0.030400 5.38e-01 6.77e-01
Signaling by WNT in cancer 28 8.69e-01 9.04e-01 0.05280 0.036300 -0.038300 7.40e-01 7.26e-01
ADP signalling through P2Y purinoceptor 12 13 9.52e-01 9.62e-01 0.05260 0.048300 0.020900 7.63e-01 8.96e-01
G-protein activation 13 9.52e-01 9.62e-01 0.05260 0.048300 0.020900 7.63e-01 8.96e-01
ABC-family proteins mediated transport 76 7.09e-01 7.73e-01 0.05240 0.050800 -0.012600 4.44e-01 8.50e-01
Activated NOTCH1 Transmits Signal to the Nucleus 24 9.10e-01 9.34e-01 0.05160 -0.051300 -0.005360 6.64e-01 9.64e-01
IGF1R signaling cascade 30 9.10e-01 9.34e-01 0.04910 0.027800 0.040500 7.92e-01 7.02e-01
FCERI mediated MAPK activation 23 9.17e-01 9.36e-01 0.04870 -0.005820 0.048300 9.61e-01 6.89e-01
Regulation of Complement cascade 13 9.51e-01 9.62e-01 0.04860 0.047700 -0.009510 7.66e-01 9.53e-01
COPI-mediated anterograde transport 73 8.01e-01 8.50e-01 0.04850 0.027800 0.039800 6.82e-01 5.57e-01
Peptide hormone metabolism 39 8.93e-01 9.21e-01 0.04530 0.011200 0.043900 9.04e-01 6.36e-01
mTORC1-mediated signalling 23 9.44e-01 9.57e-01 0.04350 -0.021700 -0.037700 8.57e-01 7.55e-01
IRS-mediated signalling 27 9.41e-01 9.54e-01 0.04210 0.031000 0.028500 7.81e-01 7.98e-01
ADP signalling through P2Y purinoceptor 1 15 9.55e-01 9.63e-01 0.04180 -0.036500 0.020500 8.07e-01 8.91e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 19 9.51e-01 9.62e-01 0.04060 -0.005170 0.040300 9.69e-01 7.61e-01
Constitutive Signaling by EGFRvIII 15 9.68e-01 9.74e-01 0.04030 0.035500 0.019100 8.12e-01 8.98e-01
Signaling by EGFRvIII in Cancer 15 9.68e-01 9.74e-01 0.04030 0.035500 0.019100 8.12e-01 8.98e-01
Class I MHC mediated antigen processing & presentation 303 5.46e-01 6.46e-01 0.04000 0.030800 0.025500 3.61e-01 4.48e-01
PI3K Cascade 23 9.54e-01 9.63e-01 0.03880 0.015100 0.035800 9.01e-01 7.67e-01
RAB GEFs exchange GTP for GDP on RABs 81 8.70e-01 9.04e-01 0.03510 0.033700 0.009820 6.01e-01 8.79e-01
PI-3K cascade:FGFR1 10 9.83e-01 9.86e-01 0.03460 -0.033500 -0.008760 8.54e-01 9.62e-01
Rab regulation of trafficking 110 8.74e-01 9.05e-01 0.03100 0.020500 0.023200 7.11e-01 6.75e-01
Base-Excision Repair, AP Site Formation 16 9.77e-01 9.81e-01 0.03090 0.030900 -0.000317 8.31e-01 9.98e-01
Complement cascade 14 9.82e-01 9.85e-01 0.03070 -0.008390 -0.029500 9.57e-01 8.48e-01
Signaling by ERBB4 37 9.62e-01 9.69e-01 0.02460 0.010700 -0.022100 9.10e-01 8.16e-01
RUNX2 regulates bone development 26 9.79e-01 9.83e-01 0.02140 -0.019000 0.009850 8.67e-01 9.31e-01
IRS-related events triggered by IGF1R 29 9.86e-01 9.87e-01 0.01820 0.000983 0.018100 9.93e-01 8.66e-01
Antigen processing: Ubiquitination & Proteasome degradation 265 8.74e-01 9.05e-01 0.01790 0.017600 -0.003080 6.24e-01 9.32e-01
Neddylation 200 9.19e-01 9.38e-01 0.01760 -0.005470 -0.016800 8.94e-01 6.84e-01
COPI-independent Golgi-to-ER retrograde traffic 27 9.94e-01 9.94e-01 0.01340 0.011800 0.006230 9.15e-01 9.55e-01
Downstream signaling of activated FGFR4 17 9.99e-01 9.99e-01 0.00742 -0.007380 0.000769 9.58e-01 9.96e-01


Detailed Gene set reports


Interleukin-10 signaling

Interleukin-10 signaling
metric value
setSize 11
pMANOVA 8.92e-06
p.adjustMANOVA 8e-05
s.dist 0.789
s.human -0.252
s.mouse 0.747
p.human 0.148
p.mouse 1.76e-05




Top 20 genes
Gene human mouse
STAT3 -3885 5061
CSF1 -4242 4358
TNFRSF1A -4666 3362
IL1R1 -3018 3910
JAK1 -1869 4228
TIMP1 -1317 5239
TNFRSF1B -874 4595

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All member genes
human mouse
CCL2 2620 5111
CSF1 -4242 4358
ICAM1 1056 4172
IL10RB 1239 3244
IL1R1 -3018 3910
JAK1 -1869 4228
STAT3 -3885 5061
TIMP1 -1317 5239
TNFRSF1A -4666 3362
TNFRSF1B -874 4595
TYK2 -3123 -50



Post-chaperonin tubulin folding pathway

Post-chaperonin tubulin folding pathway
metric value
setSize 15
pMANOVA 4.53e-07
p.adjustMANOVA 6.03e-06
s.dist 0.736
s.human -0.483
s.mouse 0.555
p.human 0.00121
p.mouse 0.000196




Top 20 genes
Gene human mouse
TUBB6 -5060 5204
TUBA1B -5324 4914
TUBA1C -4883 5125
TUBB2B -4704 4960
TUBB2A -4676 4448
TUBA1A -5228 3715
TUBA4A -5342 2072
TBCA -2582 1806
TBCE -454 498

Click HERE to show all gene set members

All member genes
human mouse
ARL2 -4142 -523
TBCA -2582 1806
TBCB 1115 3250
TBCC 3030 4719
TBCD -4133 -596
TBCE -454 498
TUBA1A -5228 3715
TUBA1B -5324 4914
TUBA1C -4883 5125
TUBA4A -5342 2072
TUBA8 -1116 -888
TUBB2A -4676 4448
TUBB2B -4704 4960
TUBB4B 430 4896
TUBB6 -5060 5204



Carnitine metabolism

Carnitine metabolism
metric value
setSize 11
pMANOVA 0.000701
p.adjustMANOVA 0.00366
s.dist 0.714
s.human -0.434
s.mouse -0.568
p.human 0.0127
p.mouse 0.00112




Top 20 genes
Gene human mouse
RXRA -5519 -4191
THRSP -4308 -4642
PRKAA2 -3219 -5163
SLC22A5 -4653 -2940
PRKAG2 -3237 -3533
PPARD -4213 -2337
PRKAB2 -2332 -2820
SLC25A20 -3511 -1437

Click HERE to show all gene set members

All member genes
human mouse
CPT1A -357 330
CPT2 555 -5292
MID1IP1 2058 -1719
PPARD -4213 -2337
PRKAA2 -3219 -5163
PRKAB2 -2332 -2820
PRKAG2 -3237 -3533
RXRA -5519 -4191
SLC22A5 -4653 -2940
SLC25A20 -3511 -1437
THRSP -4308 -4642



rRNA modification in the nucleus and cytosol

rRNA modification in the nucleus and cytosol
metric value
setSize 52
pMANOVA 3.48e-15
p.adjustMANOVA 3.3e-13
s.dist 0.698
s.human 0.6
s.mouse 0.356
p.human 7.07e-14
p.mouse 8.87e-06




Top 20 genes
Gene human mouse
UTP14A 4777 5037.5
NOP58 4891 4343.0
DCAF13 4800 4163.0
GAR1 4132 4763.0
HEATR1 4911 3855.0
WDR3 4838 3546.0
WDR43 4883 3479.0
NOP2 3472 4824.0
WDR36 4542 3505.0
UTP3 4917 2928.0
UTP18 3851 3736.0
IMP4 2805 4315.0
NOP56 3099 3859.0
UTP15 4137 2775.0
MPHOSPH10 3928 2826.0
NOL6 3819 2763.0
FBL 4233 2213.0
WDR75 3743 2374.0
WDR46 3335 2646.0
DDX49 2178 4026.0

Click HERE to show all gene set members

All member genes
human mouse
BMS1 3511 -4218.0
DCAF13 4800 4163.0
DDX47 3735 1436.0
DDX49 2178 4026.0
DHX37 2105 2976.0
DIEXF 4877 1147.0
DIMT1 2537 1451.0
DKC1 3629 -171.0
FBL 4233 2213.0
FCF1 3303 2053.0
GAR1 4132 4763.0
HEATR1 4911 3855.0
IMP3 4536 -961.0
IMP4 2805 4315.0
KRR1 3921 1112.0
MPHOSPH10 3928 2826.0
NAT10 3642 -1157.0
NHP2 694 2676.0
NOC4L 1763 2013.0
NOL11 4916 -392.0
NOL6 3819 2763.0
NOP10 1336 911.0
NOP14 1590 4393.0
NOP2 3472 4824.0
NOP56 3099 3859.0
NOP58 4891 4343.0
PDCD11 -1465 815.0
PNO1 4623 332.0
PWP2 2462 745.0
RCL1 3257 -48.0
RPS14 -1412 1322.0
RPS6 -245 3549.0
RPS9 -1107 1580.0
RRP36 1532 1854.0
RRP7A 2138 3626.0
RRP9 771 2325.0
TBL3 -1551 1063.0
THUMPD1 4666 -2564.0
TSR3 -3611 -3279.0
UTP14A 4777 5037.5
UTP14C 1565 5037.5
UTP15 4137 2775.0
UTP18 3851 3736.0
UTP20 4174 240.0
UTP3 4917 2928.0
UTP6 4779 -4513.0
WBSCR22 1741 -1538.0
WDR3 4838 3546.0
WDR36 4542 3505.0
WDR43 4883 3479.0
WDR46 3335 2646.0
WDR75 3743 2374.0



Formation of tubulin folding intermediates by CCT/TriC

Formation of tubulin folding intermediates by CCT/TriC
metric value
setSize 17
pMANOVA 2.18e-06
p.adjustMANOVA 2.38e-05
s.dist 0.69
s.human -0.0952
s.mouse 0.683
p.human 0.497
p.mouse 1.08e-06




Top 20 genes
Gene human mouse
TUBB6 -5060 5204
TUBA1B -5324 4914
TUBA1C -4883 5125
TUBB2B -4704 4960
TUBB2A -4676 4448
TUBA1A -5228 3715
TUBA4A -5342 2072

Click HERE to show all gene set members

All member genes
human mouse
CCT2 3805 4207
CCT3 2328 4908
CCT4 950 3331
CCT5 3075 2636
CCT6A 2932 3034
CCT7 436 3380
CCT8 4149 3796
TCP1 4480 1210
TUBA1A -5228 3715
TUBA1B -5324 4914
TUBA1C -4883 5125
TUBA4A -5342 2072
TUBA8 -1116 -888
TUBB2A -4676 4448
TUBB2B -4704 4960
TUBB4B 430 4896
TUBB6 -5060 5204



Signal regulatory protein family interactions

Signal regulatory protein family interactions
metric value
setSize 10
pMANOVA 0.000469
p.adjustMANOVA 0.00251
s.dist 0.654
s.human -0.412
s.mouse 0.507
p.human 0.0241
p.mouse 0.00548




Top 20 genes
Gene human mouse
SIRPA -5627 4222
GRB2 -4050 4496
PTK2B -2461 3862
FYB -2235 3488
CD47 -2184 2680
SRC -3910 1378
PTPN6 -931 4799

Click HERE to show all gene set members

All member genes
human mouse
CD47 -2184 2680
FYB -2235 3488
GRB2 -4050 4496
PTK2 -2497 -1508
PTK2B -2461 3862
PTPN11 -1575 -666
PTPN6 -931 4799
SIRPA -5627 4222
SKAP2 518 3773
SRC -3910 1378



Regulation of pyruvate dehydrogenase (PDH) complex

Regulation of pyruvate dehydrogenase (PDH) complex
metric value
setSize 15
pMANOVA 0.000121
p.adjustMANOVA 8e-04
s.dist 0.651
s.human -0.162
s.mouse -0.631
p.human 0.277
p.mouse 2.33e-05




Top 20 genes
Gene human mouse
RXRA -5519 -4191
PDK2 -5450 -3535
PDHA1 -2405 -4451
PDP1 -2175 -4603
PPARD -4213 -2337
GSTZ1 -2068 -4631
DLAT -1960 -3824
PDP2 -2619 -2438
PDK4 -712 -5238
PDPR -632 -4831
PDHB -133 -3995
PDHX -126 -3872

Click HERE to show all gene set members

All member genes
human mouse
DLAT -1960 -3824
DLD 1187 -4737
GSTZ1 -2068 -4631
PDHA1 -2405 -4451
PDHB -133 -3995
PDHX -126 -3872
PDK1 4600 -3234
PDK2 -5450 -3535
PDK3 4747 4864
PDK4 -712 -5238
PDP1 -2175 -4603
PDP2 -2619 -2438
PDPR -632 -4831
PPARD -4213 -2337
RXRA -5519 -4191



Postmitotic nuclear pore complex (NPC) reformation

Postmitotic nuclear pore complex (NPC) reformation
metric value
setSize 24
pMANOVA 2.04e-06
p.adjustMANOVA 2.25e-05
s.dist 0.646
s.human 0.543
s.mouse 0.35
p.human 4.11e-06
p.mouse 0.00297




Top 20 genes
Gene human mouse
NUP98 4235 5066
NUP54 4508 3831
TNPO1 3184 5129
NUP205 4438 3588
KPNB1 3619 3517
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
SUMO1 4213 1399
SEH1L 1085 4263
RAN 2329 1938
NUP160 3998 1035
RCC1 997 3619
NUP35 4571 649
RANGAP1 483 4340
UBE2I 1246 1214
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AHCTF1 4662 -1792
KPNB1 3619 3517
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP93 -1503 3903
NUP98 4235 5066
RAN 2329 1938
RANGAP1 483 4340
RCC1 997 3619
SEC13 730 1702
SEH1L 1085 4263
SUMO1 4213 1399
TNPO1 3184 5129
UBE2I 1246 1214



Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)
metric value
setSize 21
pMANOVA 7.05e-06
p.adjustMANOVA 6.48e-05
s.dist 0.644
s.human -0.243
s.mouse -0.597
p.human 0.0539
p.mouse 2.22e-06




Top 20 genes
Gene human mouse
SDHA -4773 -4591
IDH2 -5216 -3854
OGDH -5268 -3650
ACO2 -3822 -4426
IDH3G -4178 -3128
MDH2 -4361 -2855
SDHC -3712 -3001
IDH3A -2155 -3823
NNT -3325 -2371
FAHD1 -1771 -4302
IDH3B -2881 -2173
SUCLG2 -1167 -4291
DLST -323 -3527
SUCLG1 -31 -2136

Click HERE to show all gene set members

All member genes
human mouse
ACO2 -3822 -4426
CS 3653 -3566
DLD 1187 -4737
DLST -323 -3527
FAHD1 -1771 -4302
FH 287 -2895
IDH2 -5216 -3854
IDH3A -2155 -3823
IDH3B -2881 -2173
IDH3G -4178 -3128
MDH2 -4361 -2855
ME2 -1789 3526
ME3 4207 -3719
NNT -3325 -2371
OGDH -5268 -3650
SDHA -4773 -4591
SDHB 431 -3707
SDHC -3712 -3001
SUCLA2 1517 -4376
SUCLG1 -31 -2136
SUCLG2 -1167 -4291



Mitochondrial Fatty Acid Beta-Oxidation

Mitochondrial Fatty Acid Beta-Oxidation
metric value
setSize 30
pMANOVA 8.79e-08
p.adjustMANOVA 1.51e-06
s.dist 0.643
s.human -0.336
s.mouse -0.548
p.human 0.00148
p.mouse 2.05e-07




Top 20 genes
Gene human mouse
ACOT11 -5260 -5320.0
ACAD10 -4565 -4895.0
ACADVL -4952 -4299.0
ACADS -4663 -3992.0
ECHS1 -3895 -4777.0
ACOT2 -2912 -5151.5
HADH -2786 -5187.0
ECI1 -3975 -3414.0
PCCA -2597 -5205.0
DECR1 -2617 -4783.0
ACAA2 -2330 -4994.0
ACOT13 -2994 -3100.0
HADHA -3202 -2497.0
ACADM -1714 -4540.0
HADHB -2035 -3610.0
MECR -3190 -1721.0
ACADL -1021 -3930.0
MCEE -816 -4754.0
THEM4 -3616 -500.0
MCAT -628 -2815.0

Click HERE to show all gene set members

All member genes
human mouse
ACAA2 -2330 -4994.0
ACAD10 -4565 -4895.0
ACAD11 421 -4580.0
ACADL -1021 -3930.0
ACADM -1714 -4540.0
ACADS -4663 -3992.0
ACADVL -4952 -4299.0
ACOT1 1587 -5151.5
ACOT11 -5260 -5320.0
ACOT13 -2994 -3100.0
ACOT2 -2912 -5151.5
ACOT7 -716 3041.0
ACOT9 478 4970.0
ACSF2 -5148 1463.0
DBI -2859 4399.0
DECR1 -2617 -4783.0
ECHS1 -3895 -4777.0
ECI1 -3975 -3414.0
HADH -2786 -5187.0
HADHA -3202 -2497.0
HADHB -2035 -3610.0
MCAT -628 -2815.0
MCEE -816 -4754.0
MECR -3190 -1721.0
MMAA 2798 -4327.0
NDUFAB1 1151 -3257.0
PCCA -2597 -5205.0
PCCB -165 -4143.0
PCTP -322 -1700.0
THEM4 -3616 -500.0



Voltage gated Potassium channels

Voltage gated Potassium channels
metric value
setSize 11
pMANOVA 0.00282
p.adjustMANOVA 0.0115
s.dist 0.64
s.human -0.529
s.mouse -0.362
p.human 0.00241
p.mouse 0.0379




Top 20 genes
Gene human mouse
KCNQ4 -5622 -5032
KCNB1 -5117 -5063
KCNC4 -4909 -5275
KCNA7 -5142 -3486
KCNQ5 -3754 -4765
KCNC1 -3339 -5316
KCNH2 -3531 -1483

Click HERE to show all gene set members

All member genes
human mouse
KCNA1 4597 2127
KCNA7 -5142 -3486
KCNAB2 -3198 5020
KCNB1 -5117 -5063
KCNC1 -3339 -5316
KCNC3 -365 1019
KCNC4 -4909 -5275
KCNH2 -3531 -1483
KCNQ1 -3887 564
KCNQ4 -5622 -5032
KCNQ5 -3754 -4765



Transport of the SLBP Dependant Mature mRNA

Transport of the SLBP Dependant Mature mRNA
metric value
setSize 29
pMANOVA 1.89e-07
p.adjustMANOVA 2.65e-06
s.dist 0.635
s.human 0.556
s.mouse 0.307
p.human 2.2e-07
p.mouse 0.00419




Top 20 genes
Gene human mouse
ALYREF 5008 5231
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
SLBP 2666 4952
EIF4E 2892 3735
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
SEH1L 1085 4263
NUP160 3998 1035
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
SEC13 730 1702
NCBP2 4188 264

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
ALYREF 5008 5231
EIF4E 2892 3735
NCBP1 -1736 4182
NCBP2 4188 264
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
NXF1 4992 -57
RAE1 4471 2389
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
SLBP 2666 4952
TPR 2984 -1026



Striated Muscle Contraction

Striated Muscle Contraction
metric value
setSize 30
pMANOVA 5.73e-08
p.adjustMANOVA 1.02e-06
s.dist 0.631
s.human -0.603
s.mouse -0.187
p.human 1.1e-08
p.mouse 0.076




Top 20 genes
Gene human mouse
MYBPC2 -5048 -5125
TMOD1 -5339 -4444
MYL3 -3976 -5357
TPM1 -4592 -4022
TNNI2 -4910 -3398
TPM2 -3443 -4506
TCAP -5032 -2912
TNNT3 -4247 -3376
DMD -2970 -4510
NEB -2805 -4575
MYL4 -4626 -2026
MYH3 -4216 -2162
TNNC2 -4220 -1789
MYL1 -1989 -3616
TNNT1 -4248 -1116
TNNI1 -3744 -976
MYBPC1 -4465 -758
TNNT2 -3984 -390
TMOD2 -2848 -138

Click HERE to show all gene set members

All member genes
human mouse
ACTN2 -3104 3454
DES -4740 4798
DMD -2970 -4510
MYBPC1 -4465 -758
MYBPC2 -5048 -5125
MYH3 -4216 -2162
MYH6 -4746 1905
MYH8 -4002 4013
MYL1 -1989 -3616
MYL2 -4849 566
MYL3 -3976 -5357
MYL4 -4626 -2026
NEB -2805 -4575
TCAP -5032 -2912
TMOD1 -5339 -4444
TMOD2 -2848 -138
TMOD3 376 1007
TNNC1 -4638 612
TNNC2 -4220 -1789
TNNI1 -3744 -976
TNNI2 -4910 -3398
TNNT1 -4248 -1116
TNNT2 -3984 -390
TNNT3 -4247 -3376
TPM1 -4592 -4022
TPM2 -3443 -4506
TPM3 -3868 2581
TPM4 191 4657
TTN 3968 -4448
VIM -3027 4772



Phase 0 - rapid depolarisation

Phase 0 - rapid depolarisation
metric value
setSize 18
pMANOVA 6.59e-05
p.adjustMANOVA 0.000467
s.dist 0.628
s.human -0.579
s.mouse -0.242
p.human 2.11e-05
p.mouse 0.0758




Top 20 genes
Gene human mouse
SCN4A -5601 -5087
CACNB1 -5285 -5348
SCN1B -4899 -5314
CAMK2A -5527 -4430
CACNG6 -5276 -4552
CAMK2B -5497 -4230
FGF11 -3896 -3735
CAMK2G -2097 -4962
SCN2B -4268 -1921
CACNA1C -762 -668

Click HERE to show all gene set members

All member genes
human mouse
CACNA1C -762 -668
CACNB1 -5285 -5348
CACNG6 -5276 -4552
CALM1 -4464 96
CAMK2A -5527 -4430
CAMK2B -5497 -4230
CAMK2D -2223 4137
CAMK2G -2097 -4962
FGF11 -3896 -3735
FGF13 -844 616
RANGRF -4019 157
SCN1B -4899 -5314
SCN2A 544 316
SCN2B -4268 -1921
SCN3A 2439 4422
SCN3B -3892 2980
SCN4A -5601 -5087
SCN5A -5309 3520



Transport of the SLBP independent Mature mRNA

Transport of the SLBP independent Mature mRNA
metric value
setSize 28
pMANOVA 4.83e-07
p.adjustMANOVA 6.33e-06
s.dist 0.625
s.human 0.556
s.mouse 0.285
p.human 3.58e-07
p.mouse 0.00915




Top 20 genes
Gene human mouse
ALYREF 5008 5231
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
EIF4E 2892 3735
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
SEH1L 1085 4263
NUP160 3998 1035
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
SEC13 730 1702
NCBP2 4188 264

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
ALYREF 5008 5231
EIF4E 2892 3735
NCBP1 -1736 4182
NCBP2 4188 264
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
NXF1 4992 -57
RAE1 4471 2389
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
TPR 2984 -1026



Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle
metric value
setSize 49
pMANOVA 1.25e-11
p.adjustMANOVA 4.99e-10
s.dist 0.618
s.human -0.263
s.mouse -0.559
p.human 0.00145
p.mouse 1.28e-11




Top 20 genes
Gene human mouse
D2HGDH -4890 -5334
RXRA -5519 -4191
SDHA -4773 -4591
IDH2 -5216 -3854
SLC16A3 -4751 -4158
PDK2 -5450 -3535
OGDH -5268 -3650
ACO2 -3822 -4426
VDAC1 -2909 -4606
IDH3G -4178 -3128
MDH2 -4361 -2855
MPC1 -3681 -3235
SDHC -3712 -3001
PDHA1 -2405 -4451
PDP1 -2175 -4603
ADHFE1 -4039 -2474
PPARD -4213 -2337
GSTZ1 -2068 -4631
LDHA -3251 -2911
IDH3A -2155 -3823

Click HERE to show all gene set members

All member genes
human mouse
ACO2 -3822 -4426
ADHFE1 -4039 -2474
BSG -2248 -2113
CS 3653 -3566
D2HGDH -4890 -5334
DLAT -1960 -3824
DLD 1187 -4737
DLST -323 -3527
FAHD1 -1771 -4302
FH 287 -2895
GLO1 -678 -3885
GSTZ1 -2068 -4631
HAGH -4509 1245
IDH2 -5216 -3854
IDH3A -2155 -3823
IDH3B -2881 -2173
IDH3G -4178 -3128
L2HGDH -262 -3641
LDHA -3251 -2911
LDHB -1491 -1974
MDH2 -4361 -2855
ME1 1789 -3959
ME2 -1789 3526
ME3 4207 -3719
MPC1 -3681 -3235
MPC2 829 -1736
NNT -3325 -2371
OGDH -5268 -3650
PDHA1 -2405 -4451
PDHB -133 -3995
PDHX -126 -3872
PDK1 4600 -3234
PDK2 -5450 -3535
PDK3 4747 4864
PDK4 -712 -5238
PDP1 -2175 -4603
PDP2 -2619 -2438
PDPR -632 -4831
PPARD -4213 -2337
RXRA -5519 -4191
SDHA -4773 -4591
SDHB 431 -3707
SDHC -3712 -3001
SLC16A1 -987 5075
SLC16A3 -4751 -4158
SUCLA2 1517 -4376
SUCLG1 -31 -2136
SUCLG2 -1167 -4291
VDAC1 -2909 -4606



Gluconeogenesis

Gluconeogenesis
metric value
setSize 23
pMANOVA 9.76e-06
p.adjustMANOVA 8.6e-05
s.dist 0.617
s.human -0.535
s.mouse -0.306
p.human 8.82e-06
p.mouse 0.0111




Top 20 genes
Gene human mouse
SLC25A12 -5347 -4548
SLC37A4 -4766 -5052
GPI -5210 -4132
ALDOA -5575 -3482
PC -5226 -3696
SLC25A11 -4108 -3843
PGAM2 -5379 -2929
TPI1 -3377 -4476
ENO3 -4671 -2856
MDH2 -4361 -2855
GOT2 -3704 -3090
FBP2 -3323 -3226
PGK1 -1414 -3515
GOT1 -3758 -1252
G6PC3 -3066 -1492
MDH1 -1091 -3643
SLC37A1 -2590 -201

Click HERE to show all gene set members

All member genes
human mouse
ALDOA -5575 -3482
ALDOC 1379 4707
ENO1 -4083 2473
ENO2 -2024 901
ENO3 -4671 -2856
FBP2 -3323 -3226
G6PC3 -3066 -1492
GOT1 -3758 -1252
GOT2 -3704 -3090
GPI -5210 -4132
MDH1 -1091 -3643
MDH2 -4361 -2855
PC -5226 -3696
PCK2 -2317 375
PGAM2 -5379 -2929
PGK1 -1414 -3515
SLC25A1 -2688 3732
SLC25A11 -4108 -3843
SLC25A12 -5347 -4548
SLC25A13 4283 3607
SLC37A1 -2590 -201
SLC37A4 -4766 -5052
TPI1 -3377 -4476



Export of Viral Ribonucleoproteins from Nucleus

Export of Viral Ribonucleoproteins from Nucleus
metric value
setSize 26
pMANOVA 2.73e-06
p.adjustMANOVA 2.85e-05
s.dist 0.608
s.human 0.542
s.mouse 0.275
p.human 1.69e-06
p.mouse 0.0154




Top 20 genes
Gene human mouse
HSPA1A 4887 5277.5
NUP98 4235 5066.0
NUP54 4508 3831.0
NUP205 4438 3588.0
RAE1 4471 2389.0
NUP43 4562 2216.0
NUP107 3232 2949.0
NUP188 2117 3830.0
NUP153 4762 1533.0
SEH1L 1085 4263.0
RAN 2329 1938.0
NUP160 3998 1035.0
NUP35 4571 649.0
NUP88 1244 2212.0
NUP214 3124 665.0
XPO1 990 1809.0
SEC13 730 1702.0

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550.0
HSPA1A 4887 5277.5
NDC1 1273 -2350.0
NUP107 3232 2949.0
NUP133 889 -4048.0
NUP153 4762 1533.0
NUP155 4306 -2233.0
NUP160 3998 1035.0
NUP188 2117 3830.0
NUP205 4438 3588.0
NUP214 3124 665.0
NUP35 4571 649.0
NUP37 -327 192.0
NUP43 4562 2216.0
NUP54 4508 3831.0
NUP85 3181 -393.0
NUP88 1244 2212.0
NUP93 -1503 3903.0
NUP98 4235 5066.0
RAE1 4471 2389.0
RAN 2329 1938.0
RANBP2 4470 -3848.0
SEC13 730 1702.0
SEH1L 1085 4263.0
TPR 2984 -1026.0
XPO1 990 1809.0



Transport of Ribonucleoproteins into the Host Nucleus

Transport of Ribonucleoproteins into the Host Nucleus
metric value
setSize 25
pMANOVA 5.04e-06
p.adjustMANOVA 4.81e-05
s.dist 0.605
s.human 0.541
s.mouse 0.27
p.human 2.84e-06
p.mouse 0.0197




Top 20 genes
Gene human mouse
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
KPNB1 3619 3517
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
KPNA1 1833 3439
SEH1L 1085 4263
NUP160 3998 1035
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
KPNA1 1833 3439
KPNB1 3619 3517
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
RAE1 4471 2389
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
TPR 2984 -1026



Metabolism of non-coding RNA

Metabolism of non-coding RNA
metric value
setSize 45
pMANOVA 2.2e-10
p.adjustMANOVA 7.14e-09
s.dist 0.604
s.human 0.556
s.mouse 0.236
p.human 1.1e-10
p.mouse 0.00624




Top 20 genes
Gene human mouse
NUP98 4235 5066.0
NUP54 4508 3831.0
SNRPD1 3996 4006.0
NUP205 4438 3588.0
SNRPG 3179 3615.0
GEMIN6 3429 3153.0
RAE1 4471 2389.0
DDX20 4951 2067.0
NUP43 4562 2216.0
NUP107 3232 2949.0
TGS1 4576 2059.0
SNRPF 3777 2400.0
NUP188 2117 3830.0
NUP153 4762 1533.0
SMN1 4028 1732.5
GEMIN7 2344 2332.0
SEH1L 1085 4263.0
NUP160 3998 1035.0
PHAX 4729 840.0
NUP35 4571 649.0

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550.0
CLNS1A 155 632.0
DDX20 4951 2067.0
GEMIN2 3264 -1096.0
GEMIN5 4699 -3017.0
GEMIN6 3429 3153.0
GEMIN7 2344 2332.0
GEMIN8 94 982.0
NCBP1 -1736 4182.0
NCBP2 4188 264.0
NDC1 1273 -2350.0
NUP107 3232 2949.0
NUP133 889 -4048.0
NUP153 4762 1533.0
NUP155 4306 -2233.0
NUP160 3998 1035.0
NUP188 2117 3830.0
NUP205 4438 3588.0
NUP214 3124 665.0
NUP35 4571 649.0
NUP37 -327 192.0
NUP43 4562 2216.0
NUP54 4508 3831.0
NUP85 3181 -393.0
NUP88 1244 2212.0
NUP93 -1503 3903.0
NUP98 4235 5066.0
PHAX 4729 840.0
PRMT5 933 1373.0
RAE1 4471 2389.0
RANBP2 4470 -3848.0
SEC13 730 1702.0
SEH1L 1085 4263.0
SMN1 4028 1732.5
SNRPB 3761 35.0
SNRPD1 3996 4006.0
SNRPD2 2043 -304.0
SNRPD3 2384 -1603.0
SNRPE 3421 760.0
SNRPF 3777 2400.0
SNRPG 3179 3615.0
SNUPN 2836 588.0
TGS1 4576 2059.0
TPR 2984 -1026.0
WDR77 -799 1494.0



snRNP Assembly

snRNP Assembly
metric value
setSize 45
pMANOVA 2.2e-10
p.adjustMANOVA 7.14e-09
s.dist 0.604
s.human 0.556
s.mouse 0.236
p.human 1.1e-10
p.mouse 0.00624




Top 20 genes
Gene human mouse
NUP98 4235 5066.0
NUP54 4508 3831.0
SNRPD1 3996 4006.0
NUP205 4438 3588.0
SNRPG 3179 3615.0
GEMIN6 3429 3153.0
RAE1 4471 2389.0
DDX20 4951 2067.0
NUP43 4562 2216.0
NUP107 3232 2949.0
TGS1 4576 2059.0
SNRPF 3777 2400.0
NUP188 2117 3830.0
NUP153 4762 1533.0
SMN1 4028 1732.5
GEMIN7 2344 2332.0
SEH1L 1085 4263.0
NUP160 3998 1035.0
PHAX 4729 840.0
NUP35 4571 649.0

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550.0
CLNS1A 155 632.0
DDX20 4951 2067.0
GEMIN2 3264 -1096.0
GEMIN5 4699 -3017.0
GEMIN6 3429 3153.0
GEMIN7 2344 2332.0
GEMIN8 94 982.0
NCBP1 -1736 4182.0
NCBP2 4188 264.0
NDC1 1273 -2350.0
NUP107 3232 2949.0
NUP133 889 -4048.0
NUP153 4762 1533.0
NUP155 4306 -2233.0
NUP160 3998 1035.0
NUP188 2117 3830.0
NUP205 4438 3588.0
NUP214 3124 665.0
NUP35 4571 649.0
NUP37 -327 192.0
NUP43 4562 2216.0
NUP54 4508 3831.0
NUP85 3181 -393.0
NUP88 1244 2212.0
NUP93 -1503 3903.0
NUP98 4235 5066.0
PHAX 4729 840.0
PRMT5 933 1373.0
RAE1 4471 2389.0
RANBP2 4470 -3848.0
SEC13 730 1702.0
SEH1L 1085 4263.0
SMN1 4028 1732.5
SNRPB 3761 35.0
SNRPD1 3996 4006.0
SNRPD2 2043 -304.0
SNRPD3 2384 -1603.0
SNRPE 3421 760.0
SNRPF 3777 2400.0
SNRPG 3179 3615.0
SNUPN 2836 588.0
TGS1 4576 2059.0
TPR 2984 -1026.0
WDR77 -799 1494.0



Nuclear import of Rev protein

Nuclear import of Rev protein
metric value
setSize 26
pMANOVA 3.89e-06
p.adjustMANOVA 3.9e-05
s.dist 0.6
s.human 0.533
s.mouse 0.275
p.human 2.52e-06
p.mouse 0.0153




Top 20 genes
Gene human mouse
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
KPNB1 3619 3517
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
SEH1L 1085 4263
RAN 2329 1938
NUP160 3998 1035
RCC1 997 3619
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
KPNB1 3619 3517
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
RAE1 4471 2389
RAN 2329 1938
RANBP2 4470 -3848
RCC1 997 3619
SEC13 730 1702
SEH1L 1085 4263
TPR 2984 -1026



SUMOylation of SUMOylation proteins

SUMOylation of SUMOylation proteins
metric value
setSize 27
pMANOVA 2.26e-06
p.adjustMANOVA 2.45e-05
s.dist 0.599
s.human 0.542
s.mouse 0.254
p.human 1.08e-06
p.mouse 0.0226




Top 20 genes
Gene human mouse
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
TOPORS 4963 2735
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
SUMO1 4213 1399
SEH1L 1085 4263
NUP160 3998 1035
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
UBE2I 1246 1214
SEC13 730 1702
PIAS4 342 2088

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
PIAS4 342 2088
RAE1 4471 2389
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
SUMO1 4213 1399
TOPORS 4963 2735
TPR 2984 -1026
UBE2I 1246 1214



Glycogen breakdown (glycogenolysis)

Glycogen breakdown (glycogenolysis)
metric value
setSize 14
pMANOVA 0.00124
p.adjustMANOVA 0.00594
s.dist 0.597
s.human -0.538
s.mouse -0.259
p.human 0.000492
p.mouse 0.0936




Top 20 genes
Gene human mouse
PHKG1 -5495 -5329
AGL -4967 -5094
PYGM -5462 -4619
PHKA1 -3965 -5221
GAA -5001 -3369
PHKB -3289 -5059
PHKA2 -3873 -4213

Click HERE to show all gene set members

All member genes
human mouse
AGL -4967 -5094
CALM1 -4464 96
GAA -5001 -3369
GYG1 -3875 4435
PGM2 -561 3964
PGM2L1 4913 -4790
PHKA1 -3965 -5221
PHKA2 -3873 -4213
PHKB -3289 -5059
PHKG1 -5495 -5329
PHKG2 -225 3213
PYGB -4498 1915
PYGL -3546 4121
PYGM -5462 -4619



SUMOylation of ubiquitinylation proteins

SUMOylation of ubiquitinylation proteins
metric value
setSize 31
pMANOVA 4.54e-07
p.adjustMANOVA 6.03e-06
s.dist 0.595
s.human 0.53
s.mouse 0.27
p.human 3.33e-07
p.mouse 0.00922




Top 20 genes
Gene human mouse
NUP98 4235 5066
TRIM27 4120 4461
NUP54 4508 3831
NUP205 4438 3588
PML 3338 3449
MDM2 3253 3321
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
SUMO1 4213 1399
SEH1L 1085 4263
NUP160 3998 1035
PIAS2 2406 1628
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
UBE2I 1246 1214
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
MDM2 3253 3321
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
PIAS1 57 -2190
PIAS2 2406 1628
PIAS4 342 2088
PML 3338 3449
RAE1 4471 2389
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
SUMO1 4213 1399
TPR 2984 -1026
TRIM27 4120 4461
UBE2I 1246 1214



Heme biosynthesis

Heme biosynthesis
metric value
setSize 12
pMANOVA 0.00228
p.adjustMANOVA 0.00971
s.dist 0.595
s.human -0.128
s.mouse -0.581
p.human 0.444
p.mouse 0.000496




Top 20 genes
Gene human mouse
FECH -3768 -4141
ALAD -3855 -3630
PPOX -3785 -3675
UROS -1848 -4416
HMBS -3958 -1600
CPOX -865 -3572

Click HERE to show all gene set members

All member genes
human mouse
ABCG2 -2465 4953
ALAD -3855 -3630
ALAS1 3230 -4716
COX10 2735 -3718
COX15 571 -5210
CPOX -865 -3572
FECH -3768 -4141
FLVCR1 1431 -4678
HMBS -3958 -1600
PPOX -3785 -3675
UROD 795 -3244
UROS -1848 -4416



Mitochondrial tRNA aminoacylation

Mitochondrial tRNA aminoacylation
metric value
setSize 18
pMANOVA 2.34e-05
p.adjustMANOVA 0.000185
s.dist 0.592
s.human 0.178
s.mouse -0.565
p.human 0.19
p.mouse 3.38e-05




Top 20 genes
Gene human mouse
HARS2 4723 -2748
YARS2 4860 -2303
IARS2 1951 -5227
MARS2 4685 -2100
LARS2 2120 -4060
FARS2 2754 -2964
NARS2 2046 -3354
DARS2 1640 -3132
PARS2 2650 -206

Click HERE to show all gene set members

All member genes
human mouse
AARS2 -2670 -4626
CARS2 -2768 -3330
DARS2 1640 -3132
EARS2 -2493 -1506
FARS2 2754 -2964
HARS2 4723 -2748
IARS2 1951 -5227
LARS2 2120 -4060
MARS2 4685 -2100
NARS2 2046 -3354
PARS2 2650 -206
PPA2 -163 -964
RARS2 -56 -2296
SARS2 -3583 -4686
TARS2 -526 -4331
VARS2 -2639 -4957
WARS2 -890 -2106
YARS2 4860 -2303



Interactions of Rev with host cellular proteins

Interactions of Rev with host cellular proteins
metric value
setSize 29
pMANOVA 1.74e-06
p.adjustMANOVA 1.95e-05
s.dist 0.592
s.human 0.499
s.mouse 0.318
p.human 3.39e-06
p.mouse 0.00302




Top 20 genes
Gene human mouse
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
KPNB1 3619 3517
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
SEH1L 1085 4263
RAN 2329 1938
NUP160 3998 1035
RCC1 997 3619
RANBP1 745 4765
NUP35 4571 649
NUP88 1244 2212
RANGAP1 483 4340
NUP214 3124 665
XPO1 990 1809
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
KPNB1 3619 3517
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
RAE1 4471 2389
RAN 2329 1938
RANBP1 745 4765
RANBP2 4470 -3848
RANGAP1 483 4340
RCC1 997 3619
SEC13 730 1702
SEH1L 1085 4263
TPR 2984 -1026
XPO1 990 1809



SUMOylation of DNA replication proteins

SUMOylation of DNA replication proteins
metric value
setSize 35
pMANOVA 1.17e-07
p.adjustMANOVA 1.85e-06
s.dist 0.591
s.human 0.499
s.mouse 0.316
p.human 3.3e-07
p.mouse 0.00121




Top 20 genes
Gene human mouse
NUP98 4235 5066
TOP2A 4691 4445
TOP1 4805 3922
NUP54 4508 3831
NUP205 4438 3588
INCENP 3676 3359
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
PCNA 1329 5082
SUMO1 4213 1399
SEH1L 1085 4263
NUP160 3998 1035
NUP35 4571 649
NUP88 1244 2212
RANGAP1 483 4340
NUP214 3124 665
PIAS3 640 2781

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
AURKA 3811 325
INCENP 3676 3359
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
PCNA 1329 5082
PIAS3 640 2781
PIAS4 342 2088
RAE1 4471 2389
RANBP2 4470 -3848
RANGAP1 483 4340
SEC13 730 1702
SEH1L 1085 4263
SUMO1 4213 1399
SUMO3 -2496 4571
TOP1 4805 3922
TOP2A 4691 4445
TOP2B 494 -4093
TPR 2984 -1026
UBE2I 1246 1214



mRNA Splicing - Major Pathway

mRNA Splicing - Major Pathway
metric value
setSize 161
pMANOVA 1.6e-32
p.adjustMANOVA 5.11e-30
s.dist 0.59
s.human 0.508
s.mouse 0.3
p.human 1.02e-28
p.mouse 6.21e-11




Top 20 genes
Gene human mouse
ALYREF 5008 5231
GTF2F1 4999 4919
CLP1 4787 5127
HNRNPF 4978 4644
WBP11 4711 4773
SF3B4 4792 4649
BUD31 4578 4660
PRPF3 4719 4411
CDC40 4670 4455
GTF2F2 4067 5069
POLR2A 3861 5046
TRA2B 4288 4466
SNRPA1 4117 4600
CHERP 4498 4178
HNRNPU 4229 4421
HSPA8 3674 5088
MAGOH 4561 4010
SLU7 4893 3614
SNW1 3618 4819
SMNDC1 4537 3789

Click HERE to show all gene set members

All member genes
human mouse
ALYREF 5008 5231
AQR 3952 3898
BCAS2 4926 -2783
BUD31 4578 4660
CASC3 9 1880
CCAR1 3856 -1363
CD2BP2 2749 -1010
CDC40 4670 4455
CDC5L 2693 2309
CHERP 4498 4178
CLP1 4787 5127
CPSF1 -3670 1693
CPSF2 -922 1961
CPSF3 1953 -1
CPSF4 862 4036
CPSF7 407 2081
CRNKL1 4682 2187
CSTF1 2216 2463
CSTF2 1437 -2189
CSTF2T 2703 4265
CSTF3 -2793 4044
CTNNBL1 -145 2378
CWC15 4989 -2691
CWC22 4974 3311
CWC27 1809 -3152
DDX23 -645 -3513
DDX42 2929 4157
DDX46 2094 -1739
DDX5 4191 -2760
DHX15 2483 4240
DHX16 3981 306
DHX38 2857 -865
DHX9 4151 322
DNAJC8 4247 1747
EFTUD2 1157 3818
EIF4A3 4491 3824
ELAVL1 2256 2925
FIP1L1 3587 1848
FUS 867 4337
GCFC2 4300 143
GPKOW 590 2936
GTF2F1 4999 4919
GTF2F2 4067 5069
HNRNPA0 2412 4465
HNRNPA1 3878 3701
HNRNPA2B1 3693 -2053
HNRNPA3 2505 2697
HNRNPC 3406 2818
HNRNPD 4343 2983
HNRNPF 4978 4644
HNRNPH1 3339 4865
HNRNPH2 2261 730
HNRNPK 3054 2784
HNRNPL 1064 224
HNRNPM 4022 -3455
HNRNPR 4406 2984
HNRNPU 4229 4421
HNRNPUL1 2433 2224
HSPA8 3674 5088
ISY1 2662 -1226
LSM2 -1347 3340
LSM3 2210 355
LSM4 -2884 -589
LSM5 2324 358
LSM6 -1177 -1931
LSM7 -3487 916
MAGOH 4561 4010
MAGOHB 2239 2185
NCBP1 -1736 4182
NCBP2 4188 264
NUDT21 3626 3457
PCBP1 -3158 3122
PCF11 -1597 -2897
PHF5A 3478 1234
PLRG1 4237 138
POLR2A 3861 5046
POLR2B 4509 -4119
POLR2C 4529 -904
POLR2D 1669 2692
POLR2E -667 1599
POLR2G 89 5112
POLR2H -3927 3497
POLR2I -154 81
POLR2K 2480 -1584
POLR2L -4314 4110
PPIE 2144 896
PPIH 594 369
PPIL1 863 1860
PPIL3 4044 -1466
PPIL4 3657 -214
PPWD1 2992 -1498
PQBP1 -379 -1361
PRCC 2656 2793
PRPF19 2441 -4538
PRPF3 4719 4411
PRPF31 1339 4183
PRPF38A 4433 2282
PRPF4 3652 -2192
PRPF40A 4797 2652
PRPF6 684 2501
PRPF8 2926 -4269
PTBP1 3063 4257
PUF60 -2093 2016
RBM17 2520 2504
RBM22 709 2550
RBM5 3930 1290
RNPS1 681 -379
SART1 759 2635
SF1 4412 3687
SF3A1 3470 1896
SF3A2 2302 3304
SF3A3 2871 2756
SF3B1 1067 3140
SF3B2 2676 -1599
SF3B3 3615 4529
SF3B4 4792 4649
SF3B5 1969 3781
SLU7 4893 3614
SMNDC1 4537 3789
SNRNP200 2626 -3909
SNRNP27 2641 -1995
SNRNP40 2967 3494
SNRNP70 -267 -706
SNRPA1 4117 4600
SNRPB 3761 35
SNRPB2 4617 2625
SNRPC 3677 169
SNRPD1 3996 4006
SNRPD2 2043 -304
SNRPD3 2384 -1603
SNRPE 3421 760
SNRPF 3777 2400
SNRPG 3179 3615
SNRPN -2163 -2931
SNW1 3618 4819
SRRM1 2285 -746
SRRM2 -1731 -3957
SRRT 4962 3050
SRSF1 1871 -429
SRSF11 3911 -4703
SRSF3 2586 3185
SRSF4 1929 4093
SRSF5 1997 -2886
SRSF6 1798 3296
SRSF7 3545 4305
SRSF9 3543 3246
SUGP1 -1552 1721
SYF2 4472 2749
SYMPK -3207 -2811
TFIP11 5002 3365
TRA2B 4288 4466
TXNL4A -698 1687
U2AF2 4337 3060
U2SURP 4199 -2963
UPF3B 1586 -4316
USP39 1526 2994
WBP11 4711 4773
WBP4 3659 -1633
WDR33 3143 1005
XAB2 2348 1369
YBX1 -681 1282



Prolactin receptor signaling

Prolactin receptor signaling
metric value
setSize 10
pMANOVA 0.00927
p.adjustMANOVA 0.0311
s.dist 0.59
s.human -0.247
s.mouse -0.536
p.human 0.177
p.mouse 0.00336




Top 20 genes
Gene human mouse
STAT5B -5022 -5306
STAT5A -4125 -4573
JAK2 -2569 -5057
CUL1 -3121 -1536
SH2B1 -3841 -971
BTRC -1187 -2758
PTPN11 -1575 -666
RBX1 -733 -968

Click HERE to show all gene set members

All member genes
human mouse
BTRC -1187 -2758
CUL1 -3121 -1536
GHR 3997 -4645
JAK2 -2569 -5057
PTPN11 -1575 -666
RBX1 -733 -968
SH2B1 -3841 -971
SKP1 2028 -2504
STAT5A -4125 -4573
STAT5B -5022 -5306



Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
metric value
setSize 23
pMANOVA 2.17e-05
p.adjustMANOVA 0.000173
s.dist 0.588
s.human 0.538
s.mouse 0.235
p.human 7.84e-06
p.mouse 0.0509




Top 20 genes
Gene human mouse
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
SEH1L 1085 4263
NUP160 3998 1035
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
RAE1 4471 2389
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
TPR 2984 -1026



Regulation of Glucokinase by Glucokinase Regulatory Protein

Regulation of Glucokinase by Glucokinase Regulatory Protein
metric value
setSize 23
pMANOVA 2.17e-05
p.adjustMANOVA 0.000173
s.dist 0.588
s.human 0.538
s.mouse 0.235
p.human 7.84e-06
p.mouse 0.0509




Top 20 genes
Gene human mouse
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
SEH1L 1085 4263
NUP160 3998 1035
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
RAE1 4471 2389
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
TPR 2984 -1026



NEP/NS2 Interacts with the Cellular Export Machinery

NEP/NS2 Interacts with the Cellular Export Machinery
metric value
setSize 25
pMANOVA 1.26e-05
p.adjustMANOVA 0.000109
s.dist 0.58
s.human 0.525
s.mouse 0.245
p.human 5.54e-06
p.mouse 0.0338




Top 20 genes
Gene human mouse
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
SEH1L 1085 4263
RAN 2329 1938
NUP160 3998 1035
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
XPO1 990 1809
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
RAE1 4471 2389
RAN 2329 1938
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
TPR 2984 -1026
XPO1 990 1809



Transport of Mature mRNA derived from an Intron-Containing Transcript

Transport of Mature mRNA derived from an Intron-Containing Transcript
metric value
setSize 60
pMANOVA 2.2e-12
p.adjustMANOVA 1.04e-10
s.dist 0.579
s.human 0.52
s.mouse 0.254
p.human 3.24e-12
p.mouse 0.000683




Top 20 genes
Gene human mouse
ALYREF 5008 5231
NUP98 4235 5066
CDC40 4670 4455
MAGOH 4561 4010
SLU7 4893 3614
NUP54 4508 3831
EIF4A3 4491 3824
NUP205 4438 3588
SRSF7 3545 4305
FYTTD1 3374 4203
U2AF2 4337 3060
SRSF9 3543 3246
RAE1 4471 2389
NUP43 4562 2216
DDX39A 3417 2816
NUP107 3232 2949
SRSF3 2586 3185
NUP188 2117 3830
SRSF4 1929 4093
THOC1 2868 2547

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
ALYREF 5008 5231
CASC3 9 1880
CDC40 4670 4455
CHTOP -574 2867
DDX39A 3417 2816
DDX39B 984 2712
DHX38 2857 -865
EIF4A3 4491 3824
FYTTD1 3374 4203
GLE1 586 -4722
MAGOH 4561 4010
MAGOHB 2239 2185
NCBP1 -1736 4182
NCBP2 4188 264
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
NXF1 4992 -57
NXT1 1765 3801
POLDIP3 -1320 4692
RAE1 4471 2389
RANBP2 4470 -3848
RNPS1 681 -379
SARNP 569 48
SEC13 730 1702
SEH1L 1085 4263
SLU7 4893 3614
SRRM1 2285 -746
SRSF1 1871 -429
SRSF11 3911 -4703
SRSF3 2586 3185
SRSF4 1929 4093
SRSF5 1997 -2886
SRSF6 1798 3296
SRSF7 3545 4305
SRSF9 3543 3246
THOC1 2868 2547
THOC2 4510 -4472
THOC3 2831 -1702
THOC5 4842 542
THOC6 -904 3700
THOC7 -873 -3339
TPR 2984 -1026
U2AF2 4337 3060
UPF3B 1586 -4316



ABC transporters in lipid homeostasis

ABC transporters in lipid homeostasis
metric value
setSize 11
pMANOVA 0.00506
p.adjustMANOVA 0.0188
s.dist 0.579
s.human -0.123
s.mouse -0.566
p.human 0.48
p.mouse 0.00116




Top 20 genes
Gene human mouse
ABCD1 -5486 -4643
ABCA2 -5333 -3550
ABCA3 -5218 -2538
PEX19 -1861 -4687
ABCA7 -4682 -710
ABCD2 -100 -4168
ABCA6 -135 -3028

Click HERE to show all gene set members

All member genes
human mouse
ABCA2 -5333 -3550
ABCA3 -5218 -2538
ABCA5 4091 -3518
ABCA6 -135 -3028
ABCA7 -4682 -710
ABCA9 792 -530
ABCD1 -5486 -4643
ABCD2 -100 -4168
ABCD3 3813 -3363
PEX19 -1861 -4687
PEX3 3593 -2892



Rev-mediated nuclear export of HIV RNA

Rev-mediated nuclear export of HIV RNA
metric value
setSize 28
pMANOVA 4.91e-06
p.adjustMANOVA 4.76e-05
s.dist 0.577
s.human 0.49
s.mouse 0.306
p.human 7.25e-06
p.mouse 0.00514




Top 20 genes
Gene human mouse
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
SEH1L 1085 4263
RAN 2329 1938
NUP160 3998 1035
RCC1 997 3619
RANBP1 745 4765
NUP35 4571 649
NUP88 1244 2212
RANGAP1 483 4340
NUP214 3124 665
XPO1 990 1809
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
RAE1 4471 2389
RAN 2329 1938
RANBP1 745 4765
RANBP2 4470 -3848
RANGAP1 483 4340
RCC1 997 3619
SEC13 730 1702
SEH1L 1085 4263
TPR 2984 -1026
XPO1 990 1809



mRNA Splicing

mRNA Splicing
metric value
setSize 169
pMANOVA 1.66e-32
p.adjustMANOVA 5.11e-30
s.dist 0.575
s.human 0.501
s.mouse 0.283
p.human 3.5e-29
p.mouse 2.56e-10




Top 20 genes
Gene human mouse
ALYREF 5008 5231
GTF2F1 4999 4919
CLP1 4787 5127
HNRNPF 4978 4644
PDCD7 4447 5165
WBP11 4711 4773
SF3B4 4792 4649
BUD31 4578 4660
PRPF3 4719 4411
CDC40 4670 4455
GTF2F2 4067 5069
POLR2A 3861 5046
TRA2B 4288 4466
SNRPA1 4117 4600
CHERP 4498 4178
HNRNPU 4229 4421
HSPA8 3674 5088
MAGOH 4561 4010
SLU7 4893 3614
SNW1 3618 4819

Click HERE to show all gene set members

All member genes
human mouse
ALYREF 5008 5231
AQR 3952 3898
BCAS2 4926 -2783
BUD31 4578 4660
CASC3 9 1880
CCAR1 3856 -1363
CD2BP2 2749 -1010
CDC40 4670 4455
CDC5L 2693 2309
CHERP 4498 4178
CLP1 4787 5127
CPSF1 -3670 1693
CPSF2 -922 1961
CPSF3 1953 -1
CPSF4 862 4036
CPSF7 407 2081
CRNKL1 4682 2187
CSTF1 2216 2463
CSTF2 1437 -2189
CSTF2T 2703 4265
CSTF3 -2793 4044
CTNNBL1 -145 2378
CWC15 4989 -2691
CWC22 4974 3311
CWC27 1809 -3152
DDX23 -645 -3513
DDX42 2929 4157
DDX46 2094 -1739
DDX5 4191 -2760
DHX15 2483 4240
DHX16 3981 306
DHX38 2857 -865
DHX9 4151 322
DNAJC8 4247 1747
EFTUD2 1157 3818
EIF4A3 4491 3824
ELAVL1 2256 2925
FIP1L1 3587 1848
FUS 867 4337
GCFC2 4300 143
GPKOW 590 2936
GTF2F1 4999 4919
GTF2F2 4067 5069
HNRNPA0 2412 4465
HNRNPA1 3878 3701
HNRNPA2B1 3693 -2053
HNRNPA3 2505 2697
HNRNPC 3406 2818
HNRNPD 4343 2983
HNRNPF 4978 4644
HNRNPH1 3339 4865
HNRNPH2 2261 730
HNRNPK 3054 2784
HNRNPL 1064 224
HNRNPM 4022 -3455
HNRNPR 4406 2984
HNRNPU 4229 4421
HNRNPUL1 2433 2224
HSPA8 3674 5088
ISY1 2662 -1226
LSM2 -1347 3340
LSM3 2210 355
LSM4 -2884 -589
LSM5 2324 358
LSM6 -1177 -1931
LSM7 -3487 916
MAGOH 4561 4010
MAGOHB 2239 2185
NCBP1 -1736 4182
NCBP2 4188 264
NUDT21 3626 3457
PCBP1 -3158 3122
PCF11 -1597 -2897
PDCD7 4447 5165
PHF5A 3478 1234
PLRG1 4237 138
POLR2A 3861 5046
POLR2B 4509 -4119
POLR2C 4529 -904
POLR2D 1669 2692
POLR2E -667 1599
POLR2G 89 5112
POLR2H -3927 3497
POLR2I -154 81
POLR2K 2480 -1584
POLR2L -4314 4110
PPIE 2144 896
PPIH 594 369
PPIL1 863 1860
PPIL3 4044 -1466
PPIL4 3657 -214
PPWD1 2992 -1498
PQBP1 -379 -1361
PRCC 2656 2793
PRPF19 2441 -4538
PRPF3 4719 4411
PRPF31 1339 4183
PRPF38A 4433 2282
PRPF4 3652 -2192
PRPF40A 4797 2652
PRPF6 684 2501
PRPF8 2926 -4269
PTBP1 3063 4257
PUF60 -2093 2016
RBM17 2520 2504
RBM22 709 2550
RBM5 3930 1290
RNPC3 -3052 951
RNPS1 681 -379
SART1 759 2635
SF1 4412 3687
SF3A1 3470 1896
SF3A2 2302 3304
SF3A3 2871 2756
SF3B1 1067 3140
SF3B2 2676 -1599
SF3B3 3615 4529
SF3B4 4792 4649
SF3B5 1969 3781
SLU7 4893 3614
SMNDC1 4537 3789
SNRNP200 2626 -3909
SNRNP25 2402 -2712
SNRNP27 2641 -1995
SNRNP35 -2744 -3140
SNRNP40 2967 3494
SNRNP48 4305 -939
SNRNP70 -267 -706
SNRPA1 4117 4600
SNRPB 3761 35
SNRPB2 4617 2625
SNRPC 3677 169
SNRPD1 3996 4006
SNRPD2 2043 -304
SNRPD3 2384 -1603
SNRPE 3421 760
SNRPF 3777 2400
SNRPG 3179 3615
SNRPN -2163 -2931
SNW1 3618 4819
SRRM1 2285 -746
SRRM2 -1731 -3957
SRRT 4962 3050
SRSF1 1871 -429
SRSF11 3911 -4703
SRSF3 2586 3185
SRSF4 1929 4093
SRSF5 1997 -2886
SRSF6 1798 3296
SRSF7 3545 4305
SRSF9 3543 3246
SUGP1 -1552 1721
SYF2 4472 2749
SYMPK -3207 -2811
TFIP11 5002 3365
TRA2B 4288 4466
TXNL4A -698 1687
U2AF2 4337 3060
U2SURP 4199 -2963
UPF3B 1586 -4316
USP39 1526 2994
WBP11 4711 4773
WBP4 3659 -1633
WDR33 3143 1005
XAB2 2348 1369
YBX1 -681 1282
ZCRB1 833 -1382
ZMAT5 1059 360
ZRSR2 4437 -1079



Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Activation of PPARGC1A (PGC-1alpha) by phosphorylation
metric value
setSize 10
pMANOVA 0.0153
p.adjustMANOVA 0.047
s.dist 0.57
s.human -0.379
s.mouse -0.426
p.human 0.0379
p.mouse 0.0198




Top 20 genes
Gene human mouse
PRKAG3 -5537 -5285
PPARGC1A -4212 -5006
PRKAA2 -3219 -5163
PRKAG2 -3237 -3533
PRKAB2 -2332 -2820
MAPK14 -1562 -1635
MAPK11 -3385 -333

Click HERE to show all gene set members

All member genes
human mouse
MAPK11 -3385 -333
MAPK12 -5264 644
MAPK14 -1562 -1635
PPARGC1A -4212 -5006
PRKAA2 -3219 -5163
PRKAB1 3436 1814
PRKAB2 -2332 -2820
PRKAG1 2103 -1806
PRKAG2 -3237 -3533
PRKAG3 -5537 -5285



Processing of Capped Intron-Containing Pre-mRNA

Processing of Capped Intron-Containing Pre-mRNA
metric value
setSize 212
pMANOVA 7.36e-40
p.adjustMANOVA 4.54e-37
s.dist 0.569
s.human 0.5
s.mouse 0.272
p.human 5.18e-36
p.mouse 9.76e-12




Top 20 genes
Gene human mouse
ALYREF 5008 5231
GTF2F1 4999 4919
CLP1 4787 5127
HNRNPF 4978 4644
PDCD7 4447 5165
WBP11 4711 4773
SF3B4 4792 4649
NUP98 4235 5066
BUD31 4578 4660
PRPF3 4719 4411
CDC40 4670 4455
GTF2F2 4067 5069
POLR2A 3861 5046
TRA2B 4288 4466
SNRPA1 4117 4600
CHERP 4498 4178
HNRNPU 4229 4421
HSPA8 3674 5088
MAGOH 4561 4010
SLU7 4893 3614

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
ALYREF 5008 5231
AQR 3952 3898
BCAS2 4926 -2783
BUD31 4578 4660
CASC3 9 1880
CCAR1 3856 -1363
CD2BP2 2749 -1010
CDC40 4670 4455
CDC5L 2693 2309
CHERP 4498 4178
CHTOP -574 2867
CLP1 4787 5127
CPSF1 -3670 1693
CPSF2 -922 1961
CPSF3 1953 -1
CPSF4 862 4036
CPSF7 407 2081
CRNKL1 4682 2187
CSTF1 2216 2463
CSTF2 1437 -2189
CSTF2T 2703 4265
CSTF3 -2793 4044
CTNNBL1 -145 2378
CWC15 4989 -2691
CWC22 4974 3311
CWC27 1809 -3152
DDX23 -645 -3513
DDX39A 3417 2816
DDX39B 984 2712
DDX42 2929 4157
DDX46 2094 -1739
DDX5 4191 -2760
DHX15 2483 4240
DHX16 3981 306
DHX38 2857 -865
DHX9 4151 322
DNAJC8 4247 1747
EFTUD2 1157 3818
EIF4A3 4491 3824
EIF4E 2892 3735
ELAVL1 2256 2925
FIP1L1 3587 1848
FUS 867 4337
FYTTD1 3374 4203
GCFC2 4300 143
GLE1 586 -4722
GPKOW 590 2936
GTF2F1 4999 4919
GTF2F2 4067 5069
HNRNPA0 2412 4465
HNRNPA1 3878 3701
HNRNPA2B1 3693 -2053
HNRNPA3 2505 2697
HNRNPC 3406 2818
HNRNPD 4343 2983
HNRNPF 4978 4644
HNRNPH1 3339 4865
HNRNPH2 2261 730
HNRNPK 3054 2784
HNRNPL 1064 224
HNRNPM 4022 -3455
HNRNPR 4406 2984
HNRNPU 4229 4421
HNRNPUL1 2433 2224
HSPA8 3674 5088
ISY1 2662 -1226
LSM2 -1347 3340
LSM3 2210 355
LSM4 -2884 -589
LSM5 2324 358
LSM6 -1177 -1931
LSM7 -3487 916
MAGOH 4561 4010
MAGOHB 2239 2185
METTL14 4358 -2575
METTL3 -3688 -545
NCBP1 -1736 4182
NCBP2 4188 264
NDC1 1273 -2350
NUDT21 3626 3457
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
NXF1 4992 -57
NXT1 1765 3801
PCBP1 -3158 3122
PCF11 -1597 -2897
PDCD7 4447 5165
PHF5A 3478 1234
PLRG1 4237 138
POLDIP3 -1320 4692
POLR2A 3861 5046
POLR2B 4509 -4119
POLR2C 4529 -904
POLR2D 1669 2692
POLR2E -667 1599
POLR2G 89 5112
POLR2H -3927 3497
POLR2I -154 81
POLR2K 2480 -1584
POLR2L -4314 4110
PPIE 2144 896
PPIH 594 369
PPIL1 863 1860
PPIL3 4044 -1466
PPIL4 3657 -214
PPWD1 2992 -1498
PQBP1 -379 -1361
PRCC 2656 2793
PRPF19 2441 -4538
PRPF3 4719 4411
PRPF31 1339 4183
PRPF38A 4433 2282
PRPF4 3652 -2192
PRPF40A 4797 2652
PRPF6 684 2501
PRPF8 2926 -4269
PTBP1 3063 4257
PUF60 -2093 2016
RAE1 4471 2389
RANBP2 4470 -3848
RBM17 2520 2504
RBM22 709 2550
RBM5 3930 1290
RNPC3 -3052 951
RNPS1 681 -379
SARNP 569 48
SART1 759 2635
SEC13 730 1702
SEH1L 1085 4263
SF1 4412 3687
SF3A1 3470 1896
SF3A2 2302 3304
SF3A3 2871 2756
SF3B1 1067 3140
SF3B2 2676 -1599
SF3B3 3615 4529
SF3B4 4792 4649
SF3B5 1969 3781
SLBP 2666 4952
SLU7 4893 3614
SMNDC1 4537 3789
SNRNP200 2626 -3909
SNRNP25 2402 -2712
SNRNP27 2641 -1995
SNRNP35 -2744 -3140
SNRNP40 2967 3494
SNRNP48 4305 -939
SNRNP70 -267 -706
SNRPA1 4117 4600
SNRPB 3761 35
SNRPB2 4617 2625
SNRPC 3677 169
SNRPD1 3996 4006
SNRPD2 2043 -304
SNRPD3 2384 -1603
SNRPE 3421 760
SNRPF 3777 2400
SNRPG 3179 3615
SNRPN -2163 -2931
SNW1 3618 4819
SRRM1 2285 -746
SRRM2 -1731 -3957
SRRT 4962 3050
SRSF1 1871 -429
SRSF11 3911 -4703
SRSF3 2586 3185
SRSF4 1929 4093
SRSF5 1997 -2886
SRSF6 1798 3296
SRSF7 3545 4305
SRSF9 3543 3246
SUGP1 -1552 1721
SYF2 4472 2749
SYMPK -3207 -2811
TFIP11 5002 3365
THOC1 2868 2547
THOC2 4510 -4472
THOC3 2831 -1702
THOC5 4842 542
THOC6 -904 3700
THOC7 -873 -3339
TPR 2984 -1026
TRA2B 4288 4466
TXNL4A -698 1687
U2AF2 4337 3060
U2SURP 4199 -2963
UPF3B 1586 -4316
USP39 1526 2994
WBP11 4711 4773
WBP4 3659 -1633
WDR33 3143 1005
WTAP 4785 2089
XAB2 2348 1369
YBX1 -681 1282
ZCRB1 833 -1382
ZMAT5 1059 360
ZRSR2 4437 -1079



Pyruvate metabolism

Pyruvate metabolism
metric value
setSize 26
pMANOVA 1.13e-05
p.adjustMANOVA 9.82e-05
s.dist 0.569
s.human -0.228
s.mouse -0.522
p.human 0.0443
p.mouse 4.16e-06




Top 20 genes
Gene human mouse
RXRA -5519 -4191
SLC16A3 -4751 -4158
PDK2 -5450 -3535
VDAC1 -2909 -4606
MPC1 -3681 -3235
PDHA1 -2405 -4451
PDP1 -2175 -4603
PPARD -4213 -2337
GSTZ1 -2068 -4631
LDHA -3251 -2911
DLAT -1960 -3824
PDP2 -2619 -2438
BSG -2248 -2113
PDK4 -712 -5238
PDPR -632 -4831
LDHB -1491 -1974
GLO1 -678 -3885
PDHB -133 -3995
PDHX -126 -3872

Click HERE to show all gene set members

All member genes
human mouse
BSG -2248 -2113
DLAT -1960 -3824
DLD 1187 -4737
GLO1 -678 -3885
GSTZ1 -2068 -4631
HAGH -4509 1245
LDHA -3251 -2911
LDHB -1491 -1974
ME1 1789 -3959
MPC1 -3681 -3235
MPC2 829 -1736
PDHA1 -2405 -4451
PDHB -133 -3995
PDHX -126 -3872
PDK1 4600 -3234
PDK2 -5450 -3535
PDK3 4747 4864
PDK4 -712 -5238
PDP1 -2175 -4603
PDP2 -2619 -2438
PDPR -632 -4831
PPARD -4213 -2337
RXRA -5519 -4191
SLC16A1 -987 5075
SLC16A3 -4751 -4158
VDAC1 -2909 -4606



Vpr-mediated nuclear import of PICs

Vpr-mediated nuclear import of PICs
metric value
setSize 27
pMANOVA 9.98e-06
p.adjustMANOVA 8.73e-05
s.dist 0.569
s.human 0.492
s.mouse 0.286
p.human 9.7e-06
p.mouse 0.0101




Top 20 genes
Gene human mouse
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
RAE1 4471 2389
NUP43 4562 2216
PSIP1 3390 2882
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
KPNA1 1833 3439
SEH1L 1085 4263
NUP160 3998 1035
HMGA1 598 5099
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
BANF1 -2281 674
HMGA1 598 5099
KPNA1 1833 3439
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
PSIP1 3390 2882
RAE1 4471 2389
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
TPR 2984 -1026



Reduction of cytosolic Ca++ levels

Reduction of cytosolic Ca++ levels
metric value
setSize 10
pMANOVA 0.0118
p.adjustMANOVA 0.0388
s.dist 0.569
s.human -0.532
s.mouse -0.202
p.human 0.00359
p.mouse 0.269




Top 20 genes
Gene human mouse
ATP2A1 -5479 -4584
ATP2B3 -4422 -5220
SLC8A3 -5477 -3886
ATP2B4 -2762 -68

Click HERE to show all gene set members

All member genes
human mouse
ATP2A1 -5479 -4584
ATP2A2 -2976 515
ATP2A3 -4467 1862
ATP2B1 2034 159
ATP2B3 -4422 -5220
ATP2B4 -2762 -68
CALM1 -4464 96
SLC8A1 754 -3579
SLC8A3 -5477 -3886
SRI -4069 3480



Interactions of Vpr with host cellular proteins

Interactions of Vpr with host cellular proteins
metric value
setSize 29
pMANOVA 8.96e-06
p.adjustMANOVA 8e-05
s.dist 0.552
s.human 0.476
s.mouse 0.28
p.human 9.21e-06
p.mouse 0.0092




Top 20 genes
Gene human mouse
NUP98 4235 5066
NUP54 4508 3831
SLC25A5 3467 4820
NUP205 4438 3588
RAE1 4471 2389
NUP43 4562 2216
PSIP1 3390 2882
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
KPNA1 1833 3439
SEH1L 1085 4263
NUP160 3998 1035
HMGA1 598 5099
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
BANF1 -2281 674
HMGA1 598 5099
KPNA1 1833 3439
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
PSIP1 3390 2882
RAE1 4471 2389
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
SLC25A4 -1327 -2889
SLC25A5 3467 4820
TPR 2984 -1026



Viral Messenger RNA Synthesis

Viral Messenger RNA Synthesis
metric value
setSize 35
pMANOVA 9e-07
p.adjustMANOVA 1.11e-05
s.dist 0.552
s.human 0.466
s.mouse 0.295
p.human 1.85e-06
p.mouse 0.00253




Top 20 genes
Gene human mouse
GTF2F1 4999 4919
NUP98 4235 5066
GTF2F2 4067 5069
POLR2A 3861 5046
NUP54 4508 3831
NUP205 4438 3588
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
SEH1L 1085 4263
POLR2D 1669 2692
NUP160 3998 1035
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
SEC13 730 1702
POLR2G 89 5112

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
GTF2F1 4999 4919
GTF2F2 4067 5069
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
POLR2A 3861 5046
POLR2B 4509 -4119
POLR2C 4529 -904
POLR2D 1669 2692
POLR2E -667 1599
POLR2G 89 5112
POLR2H -3927 3497
POLR2I -154 81
POLR2K 2480 -1584
POLR2L -4314 4110
RAE1 4471 2389
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
TPR 2984 -1026



Transport of Mature mRNAs Derived from Intronless Transcripts

Transport of Mature mRNAs Derived from Intronless Transcripts
metric value
setSize 36
pMANOVA 6.14e-07
p.adjustMANOVA 7.69e-06
s.dist 0.551
s.human 0.468
s.mouse 0.29
p.human 1.16e-06
p.mouse 0.00262




Top 20 genes
Gene human mouse
ALYREF 5008 5231
NUP98 4235 5066
NUP54 4508 3831
NUP205 4438 3588
SLBP 2666 4952
EIF4E 2892 3735
RAE1 4471 2389
NUP43 4562 2216
NUP107 3232 2949
NUP188 2117 3830
NUP153 4762 1533
FIP1L1 3587 1848
SEH1L 1085 4263
NUP160 3998 1035
CPSF4 862 4036
WDR33 3143 1005
NUP35 4571 649
NUP88 1244 2212
NUP214 3124 665
SEC13 730 1702

Click HERE to show all gene set members

All member genes
human mouse
AAAS -3476 1550
ALYREF 5008 5231
CPSF1 -3670 1693
CPSF2 -922 1961
CPSF3 1953 -1
CPSF4 862 4036
EIF4E 2892 3735
FIP1L1 3587 1848
NCBP1 -1736 4182
NCBP2 4188 264
NDC1 1273 -2350
NUP107 3232 2949
NUP133 889 -4048
NUP153 4762 1533
NUP155 4306 -2233
NUP160 3998 1035
NUP188 2117 3830
NUP205 4438 3588
NUP214 3124 665
NUP35 4571 649
NUP37 -327 192
NUP43 4562 2216
NUP54 4508 3831
NUP85 3181 -393
NUP88 1244 2212
NUP93 -1503 3903
NUP98 4235 5066
NXF1 4992 -57
RAE1 4471 2389
RANBP2 4470 -3848
SEC13 730 1702
SEH1L 1085 4263
SLBP 2666 4952
SYMPK -3207 -2811
TPR 2984 -1026
WDR33 3143 1005



Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
metric value
setSize 10
pMANOVA 0.0126
p.adjustMANOVA 0.0404
s.dist 0.551
s.human 0.109
s.mouse 0.54
p.human 0.549
p.mouse 0.00313




Top 20 genes
Gene human mouse
TANK 3655 3446
UBC 2672 4480
TICAM1 1624 4371
TLR4 1065 4916
IRF7 775 4030
TBK1 673 3485
RPS27A 783 1840

Click HERE to show all gene set members

All member genes
human mouse
IRF3 -3061 -114
IRF7 775 4030
PTPN11 -1575 -666
RPS27A 783 1840
TANK 3655 3446
TBK1 673 3485
TICAM1 1624 4371
TLR4 1065 4916
TRAF3 -3815 2462
UBC 2672 4480



HIV Transcription Initiation

HIV Transcription Initiation
metric value
setSize 40
pMANOVA 1.5e-07
p.adjustMANOVA 2.17e-06
s.dist 0.55
s.human 0.452
s.mouse 0.313
p.human 7.48e-07
p.mouse 0.000622




Top 20 genes
Gene human mouse
TAF4B 4967 5209
GTF2F1 4999 4919
TAF7 4717 4909
GTF2B 4276 5124
GTF2A1 4730 4588
GTF2F2 4067 5069
POLR2A 3861 5046
TAF3 4294 4474
TAF2 4591 3381
TAF5 4309 2830
TAF12 3100 3164
TAF13 4749 1567
POLR2D 1669 2692
GTF2H1 3886 1058
GTF2E1 2188 1803
TBP 1137 2611
ERCC2 824 2393
TAF9B 1874 519
ERCC3 473 1570
POLR2G 89 5112

Click HERE to show all gene set members

All member genes
human mouse
CCNH 3825 -1657.0
CDK7 1571 -2032.0
ERCC2 824 2393.0
ERCC3 473 1570.0
GTF2A1 4730 4588.0
GTF2A2 4648 -1742.0
GTF2B 4276 5124.0
GTF2E1 2188 1803.0
GTF2E2 2041 120.0
GTF2F1 4999 4919.0
GTF2F2 4067 5069.0
GTF2H1 3886 1058.0
GTF2H2 4419 -2446.5
GTF2H3 -1925 467.0
GTF2H5 -878 -1711.0
MNAT1 830 -2433.0
POLR2A 3861 5046.0
POLR2B 4509 -4119.0
POLR2C 4529 -904.0
POLR2D 1669 2692.0
POLR2E -667 1599.0
POLR2G 89 5112.0
POLR2H -3927 3497.0
POLR2I -154 81.0
POLR2K 2480 -1584.0
POLR2L -4314 4110.0
TAF1 1708 -350.0
TAF10 -273 2957.0
TAF11 2962 -484.0
TAF12 3100 3164.0
TAF13 4749 1567.0
TAF2 4591 3381.0
TAF3 4294 4474.0
TAF4 -1340 3063.0
TAF4B 4967 5209.0
TAF5 4309 2830.0
TAF6 -912 55.0
TAF7 4717 4909.0
TAF9B 1874 519.0
TBP 1137 2611.0



RNA Polymerase II HIV Promoter Escape

RNA Polymerase II HIV Promoter Escape
metric value
setSize 40
pMANOVA 1.5e-07
p.adjustMANOVA 2.17e-06
s.dist 0.55
s.human 0.452
s.mouse 0.313
p.human 7.48e-07
p.mouse 0.000622




Top 20 genes
Gene human mouse
TAF4B 4967 5209
GTF2F1 4999 4919
TAF7 4717 4909
GTF2B 4276 5124
GTF2A1 4730 4588
GTF2F2 4067 5069
POLR2A 3861 5046
TAF3 4294 4474
TAF2 4591 3381
TAF5 4309 2830
TAF12 3100 3164
TAF13 4749 1567
POLR2D 1669 2692
GTF2H1 3886 1058
GTF2E1 2188 1803
TBP 1137 2611
ERCC2 824 2393
TAF9B 1874 519
ERCC3 473 1570
POLR2G 89 5112

Click HERE to show all gene set members

All member genes
human mouse
CCNH 3825 -1657.0
CDK7 1571 -2032.0
ERCC2 824 2393.0
ERCC3 473 1570.0
GTF2A1 4730 4588.0
GTF2A2 4648 -1742.0
GTF2B 4276 5124.0
GTF2E1 2188 1803.0
GTF2E2 2041 120.0
GTF2F1 4999 4919.0
GTF2F2 4067 5069.0
GTF2H1 3886 1058.0
GTF2H2 4419 -2446.5
GTF2H3 -1925 467.0
GTF2H5 -878 -1711.0
MNAT1 830 -2433.0
POLR2A 3861 5046.0
POLR2B 4509 -4119.0
POLR2C 4529 -904.0
POLR2D 1669 2692.0
POLR2E -667 1599.0
POLR2G 89 5112.0
POLR2H -3927 3497.0
POLR2I -154 81.0
POLR2K 2480 -1584.0
POLR2L -4314 4110.0
TAF1 1708 -350.0
TAF10 -273 2957.0
TAF11 2962 -484.0
TAF12 3100 3164.0
TAF13 4749 1567.0
TAF2 4591 3381.0
TAF3 4294 4474.0
TAF4 -1340 3063.0
TAF4B 4967 5209.0
TAF5 4309 2830.0
TAF6 -912 55.0
TAF7 4717 4909.0
TAF9B 1874 519.0
TBP 1137 2611.0



RNA Polymerase II Promoter Escape

RNA Polymerase II Promoter Escape
metric value
setSize 40
pMANOVA 1.5e-07
p.adjustMANOVA 2.17e-06
s.dist 0.55
s.human 0.452
s.mouse 0.313
p.human 7.48e-07
p.mouse 0.000622




Top 20 genes
Gene human mouse
TAF4B 4967 5209
GTF2F1 4999 4919
TAF7 4717 4909
GTF2B 4276 5124
GTF2A1 4730 4588
GTF2F2 4067 5069
POLR2A 3861 5046
TAF3 4294 4474
TAF2 4591 3381
TAF5 4309 2830
TAF12 3100 3164
TAF13 4749 1567
POLR2D 1669 2692
GTF2H1 3886 1058
GTF2E1 2188 1803
TBP 1137 2611
ERCC2 824 2393
TAF9B 1874 519
ERCC3 473 1570
POLR2G 89 5112

Click HERE to show all gene set members

All member genes
human mouse
CCNH 3825 -1657.0
CDK7 1571 -2032.0
ERCC2 824 2393.0
ERCC3 473 1570.0
GTF2A1 4730 4588.0
GTF2A2 4648 -1742.0
GTF2B 4276 5124.0
GTF2E1 2188 1803.0
GTF2E2 2041 120.0
GTF2F1 4999 4919.0
GTF2F2 4067 5069.0
GTF2H1 3886 1058.0
GTF2H2 4419 -2446.5
GTF2H3 -1925 467.0
GTF2H5 -878 -1711.0
MNAT1 830 -2433.0
POLR2A 3861 5046.0
POLR2B 4509 -4119.0
POLR2C 4529 -904.0
POLR2D 1669 2692.0
POLR2E -667 1599.0
POLR2G 89 5112.0
POLR2H -3927 3497.0
POLR2I -154 81.0
POLR2K 2480 -1584.0
POLR2L -4314 4110.0
TAF1 1708 -350.0
TAF10 -273 2957.0
TAF11 2962 -484.0
TAF12 3100 3164.0
TAF13 4749 1567.0
TAF2 4591 3381.0
TAF3 4294 4474.0
TAF4 -1340 3063.0
TAF4B 4967 5209.0
TAF5 4309 2830.0
TAF6 -912 55.0
TAF7 4717 4909.0
TAF9B 1874 519.0
TBP 1137 2611.0



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] ggplot2_3.3.2               reshape2_1.4.4             
##  [5] beeswarm_0.2.3              gplots_3.1.0               
##  [7] gtools_3.8.2                tibble_3.0.4               
##  [9] dplyr_1.0.2                 echarts4r_0.3.3            
## [11] DESeq2_1.28.1               SummarizedExperiment_1.18.2
## [13] DelayedArray_0.14.1         matrixStats_0.57.0         
## [15] Biobase_2.48.0              GenomicRanges_1.40.0       
## [17] GenomeInfoDb_1.24.2         IRanges_2.22.2             
## [19] S4Vectors_0.26.1            BiocGenerics_0.34.0        
## [21] mitch_1.0.10               
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-6           bit64_4.0.5            RColorBrewer_1.1-2    
##  [4] rprojroot_1.3-2        tools_4.0.2            backports_1.1.10      
##  [7] R6_2.4.1               KernSmooth_2.23-17     DBI_1.1.0             
## [10] colorspace_1.4-1       withr_2.3.0            tidyselect_1.1.0      
## [13] gridExtra_2.3          bit_4.0.4              compiler_4.0.2        
## [16] desc_1.2.0             labeling_0.4.2         caTools_1.18.0        
## [19] scales_1.1.1           genefilter_1.70.0      stringr_1.4.0         
## [22] digest_0.6.26          rmarkdown_2.5          XVector_0.28.0        
## [25] pkgconfig_2.0.3        htmltools_0.5.0        highr_0.8             
## [28] fastmap_1.0.1          htmlwidgets_1.5.2      rlang_0.4.8           
## [31] RSQLite_2.2.1          shiny_1.5.0            generics_0.0.2        
## [34] farver_2.0.3           jsonlite_1.7.1         BiocParallel_1.22.0   
## [37] RCurl_1.98-1.2         magrittr_1.5           GenomeInfoDbData_1.2.3
## [40] Matrix_1.2-18          Rcpp_1.0.5             munsell_0.5.0         
## [43] lifecycle_0.2.0        stringi_1.5.3          yaml_2.2.1            
## [46] MASS_7.3-53            zlibbioc_1.34.0        plyr_1.8.6            
## [49] grid_4.0.2             blob_1.2.1             promises_1.1.1        
## [52] crayon_1.3.4           lattice_0.20-41        splines_4.0.2         
## [55] annotate_1.66.0        locfit_1.5-9.4         knitr_1.30            
## [58] pillar_1.4.6           geneplotter_1.66.0     XML_3.99-0.5          
## [61] glue_1.4.2             evaluate_0.14          vctrs_0.3.4           
## [64] httpuv_1.5.4           testthat_2.3.2         gtable_0.3.0          
## [67] purrr_0.3.4            reshape_0.8.8          assertthat_0.2.1      
## [70] xfun_0.18              mime_0.9               xtable_1.8-4          
## [73] later_1.1.0.1          survival_3.2-7         AnnotationDbi_1.50.3  
## [76] memoise_1.1.0          ellipsis_0.3.1

END of report