date generated: 2024-04-16

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
HSPA1A 103.91955
NR4A3 68.07237
HSPA1B 47.19114
DNAJB1 35.12799
MIR133A1HG -27.36199
KLF2 26.52373

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2263
num_genes_in_profile 14740
duplicated_genes_present 0
num_profile_genes_in_sets 7082
num_profile_genes_not_in_sets 7658

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2263
num_genesets_excluded 1029
num_genesets_included 1234

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 5 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Regulation of FOXO transcriptional activity by acetylation 10 1.58e-04 0.690 1.63e-03
Peptide chain elongation 87 1.06e-26 -0.663 3.28e-24
Viral mRNA Translation 87 4.35e-26 -0.655 8.94e-24
Eukaryotic Translation Elongation 91 6.79e-27 -0.651 2.79e-24
Selenocysteine synthesis 91 2.13e-26 -0.644 5.25e-24


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Regulation of FOXO transcriptional activity by acetylation 10 1.58e-04 0.690000 1.63e-03
Peptide chain elongation 87 1.06e-26 -0.663000 3.28e-24
Viral mRNA Translation 87 4.35e-26 -0.655000 8.94e-24
Eukaryotic Translation Elongation 91 6.79e-27 -0.651000 2.79e-24
Selenocysteine synthesis 91 2.13e-26 -0.644000 5.25e-24
Eukaryotic Translation Termination 91 6.47e-25 -0.625000 1.06e-22
Interleukin-6 signaling 11 4.30e-04 0.613000 3.71e-03
MECP2 regulates neuronal receptors and channels 11 5.42e-04 0.602000 4.52e-03
Formation of a pool of free 40S subunits 99 6.87e-25 -0.599000 1.06e-22
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 1.02e-22 -0.588000 9.01e-21
SRP-dependent cotranslational protein targeting to membrane 109 1.38e-24 -0.567000 1.89e-22
Selenoamino acid metabolism 112 1.82e-24 -0.558000 2.24e-22
FOXO-mediated transcription of cell cycle genes 16 1.93e-04 0.538000 1.92e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 110 2.91e-22 -0.535000 2.40e-20
Cap-dependent Translation Initiation 117 2.16e-23 -0.533000 2.05e-21
Eukaryotic Translation Initiation 117 2.16e-23 -0.533000 2.05e-21
L13a-mediated translational silencing of Ceruloplasmin expression 109 7.58e-22 -0.532000 5.85e-20
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 2.24e-03 0.532000 1.30e-02
Formation of the ternary complex, and subsequently, the 43S complex 51 9.56e-11 -0.524000 3.68e-09
Downstream signal transduction 27 2.89e-06 0.520000 6.16e-05
Glutathione conjugation 26 5.84e-06 -0.513000 1.14e-04
Signaling by NODAL 11 3.70e-03 0.506000 1.85e-02
Import of palmitoyl-CoA into the mitochondrial matrix 12 2.71e-03 0.500000 1.49e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) 37 1.74e-07 0.496000 4.58e-06
Regulation of localization of FOXO transcription factors 11 4.41e-03 0.496000 2.14e-02
Signaling by Hippo 19 2.03e-04 0.492000 1.99e-03
AKT phosphorylates targets in the nucleus 10 7.54e-03 0.488000 3.28e-02
Tie2 Signaling 14 1.88e-03 0.480000 1.17e-02
Nephrin family interactions 18 4.38e-04 0.479000 3.75e-03
Attenuation phase 22 1.12e-04 0.476000 1.25e-03
Regulation of expression of SLITs and ROBOs 155 3.45e-24 -0.472000 3.87e-22
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 6.48e-18 -0.470000 4.21e-16
Nonsense-Mediated Decay (NMD) 113 6.48e-18 -0.470000 4.21e-16
SHC1 events in EGFR signaling 10 1.02e-02 0.469000 4.11e-02
Interleukin-4 and Interleukin-13 signaling 68 3.69e-11 0.464000 1.57e-09
Regulation of signaling by CBL 14 2.66e-03 0.464000 1.48e-02
RORA activates gene expression 18 7.27e-04 0.460000 5.64e-03
Signaling by PDGF 45 1.22e-07 0.456000 3.42e-06
RUNX3 regulates NOTCH signaling 13 4.55e-03 0.454000 2.19e-02
Downstream signaling of activated FGFR3 16 1.83e-03 0.450000 1.16e-02
Signaling by FGFR3 in disease 13 5.14e-03 0.448000 2.40e-02
Signaling by FGFR3 point mutants in cancer 13 5.14e-03 0.448000 2.40e-02
Signaling by SCF-KIT 34 8.55e-06 0.441000 1.55e-04
Influenza Viral RNA Transcription and Replication 130 4.03e-18 -0.441000 2.92e-16
Regulation of RUNX1 Expression and Activity 17 1.69e-03 0.440000 1.08e-02
Constitutive Signaling by EGFRvIII 15 3.33e-03 0.438000 1.72e-02
Signaling by EGFRvIII in Cancer 15 3.33e-03 0.438000 1.72e-02
PI-3K cascade:FGFR2 11 1.27e-02 0.434000 4.73e-02
Ribosomal scanning and start codon recognition 58 1.11e-08 -0.434000 3.70e-07
The NLRP3 inflammasome 10 1.77e-02 0.433000 5.97e-02
Downstream signaling of activated FGFR2 18 1.52e-03 0.432000 9.91e-03
Translation initiation complex formation 58 1.32e-08 -0.431000 4.29e-07
Syndecan interactions 16 2.89e-03 0.430000 1.54e-02
FOXO-mediated transcription of cell death genes 15 4.05e-03 0.429000 2.00e-02
PI-3K cascade:FGFR4 11 1.39e-02 0.428000 5.08e-02
Downstream signaling of activated FGFR4 18 1.66e-03 0.428000 1.07e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 1.46e-08 -0.427000 4.51e-07
FRS-mediated FGFR3 signaling 11 1.44e-02 0.426000 5.23e-02
Interleukin-7 signaling 13 8.00e-03 0.425000 3.39e-02
Keratan sulfate biosynthesis 19 1.44e-03 0.422000 9.59e-03
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 1.19e-02 0.419000 4.53e-02
Assembly of active LPL and LIPC lipase complexes 10 2.20e-02 0.418000 7.04e-02
Regulation of PTEN mRNA translation 12 1.23e-02 0.417000 4.68e-02
SHC-mediated cascade:FGFR2 11 1.68e-02 0.416000 5.78e-02
Adenylate cyclase inhibitory pathway 12 1.27e-02 0.416000 4.73e-02
Mitochondrial translation initiation 88 1.92e-11 -0.414000 8.46e-10
Integrin alphaIIb beta3 signaling 20 1.43e-03 0.412000 9.58e-03
Integrin signaling 20 1.43e-03 0.412000 9.58e-03
MET activates RAP1 and RAC1 10 2.43e-02 0.411000 7.58e-02
SHC-mediated cascade:FGFR4 11 1.83e-02 0.411000 6.12e-02
Mitochondrial translation termination 88 4.42e-11 -0.406000 1.76e-09
Erythropoietin activates RAS 12 1.50e-02 0.406000 5.39e-02
FRS-mediated FGFR2 signaling 13 1.15e-02 0.405000 4.43e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20 1.86e-03 0.402000 1.16e-02
Complex I biogenesis 54 3.41e-07 -0.401000 8.24e-06
FRS-mediated FGFR4 signaling 13 1.25e-02 0.400000 4.71e-02
PI-3K cascade:FGFR1 12 1.68e-02 0.399000 5.78e-02
Regulation of KIT signaling 14 9.93e-03 0.398000 4.04e-02
Signaling by BMP 25 6.26e-04 0.395000 5.05e-03
Activation of the AP-1 family of transcription factors 10 3.11e-02 0.394000 9.13e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 29 2.44e-04 0.394000 2.36e-03
Platelet Aggregation (Plug Formation) 23 1.14e-03 0.392000 8.14e-03
PECAM1 interactions 10 3.20e-02 0.392000 9.30e-02
Downstream signaling of activated FGFR1 22 1.51e-03 0.391000 9.91e-03
Mitochondrial translation elongation 88 2.42e-10 -0.391000 9.06e-09
Mitochondrial iron-sulfur cluster biogenesis 12 1.99e-02 -0.388000 6.49e-02
Signaling by FGFR4 in disease 11 2.73e-02 0.384000 8.13e-02
Influenza Life Cycle 139 5.45e-15 -0.384000 2.80e-13
HDMs demethylate histones 23 1.43e-03 0.384000 9.58e-03
NOTCH4 Intracellular Domain Regulates Transcription 19 3.81e-03 0.383000 1.90e-02
SHC-mediated cascade:FGFR1 12 2.18e-02 0.383000 6.98e-02
Inflammasomes 14 1.34e-02 0.382000 4.95e-02
NOTCH3 Intracellular Domain Regulates Transcription 20 3.27e-03 0.380000 1.70e-02
Signaling by Erythropoietin 21 2.75e-03 0.377000 1.50e-02
FOXO-mediated transcription 55 1.35e-06 0.377000 3.02e-05
FRS-mediated FGFR1 signaling 14 1.47e-02 0.377000 5.31e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 3.07e-02 0.376000 9.04e-02
Interleukin-15 signaling 11 3.17e-02 0.374000 9.28e-02
Translation 289 9.50e-28 -0.374000 5.86e-25
Processing of SMDT1 15 1.22e-02 -0.374000 4.65e-02
Glutathione synthesis and recycling 10 4.18e-02 -0.372000 1.14e-01
Mitochondrial translation 94 4.79e-10 -0.372000 1.69e-08
Cell-extracellular matrix interactions 16 1.15e-02 0.365000 4.43e-02
Major pathway of rRNA processing in the nucleolus and cytosol 174 1.11e-16 -0.365000 6.70e-15
Gluconeogenesis 23 2.47e-03 -0.365000 1.39e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 5.65e-06 -0.364000 1.13e-04
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 1.57e-02 0.360000 5.48e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 1.57e-02 0.360000 5.48e-02
Constitutive Signaling by AKT1 E17K in Cancer 25 2.05e-03 0.356000 1.21e-02
rRNA processing in the nucleus and cytosol 184 1.14e-16 -0.355000 6.70e-15
Vif-mediated degradation of APOBEC3G 48 2.17e-05 -0.354000 3.66e-04
RET signaling 28 1.17e-03 0.354000 8.27e-03
Orc1 removal from chromatin 62 1.70e-06 -0.352000 3.75e-05
Influenza Infection 149 2.50e-13 -0.348000 1.14e-11
Synthesis of PIPs at the early endosome membrane 16 1.69e-02 0.345000 5.80e-02
Activation of BH3-only proteins 27 2.01e-03 0.343000 1.20e-02
Keratan sulfate/keratin metabolism 23 4.41e-03 0.343000 2.14e-02
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 22 5.49e-03 0.342000 2.52e-02
Mucopolysaccharidoses 11 5.04e-02 -0.341000 1.31e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 48 4.48e-05 -0.341000 6.36e-04
p53-Independent DNA Damage Response 48 4.48e-05 -0.341000 6.36e-04
p53-Independent G1/S DNA damage checkpoint 48 4.48e-05 -0.341000 6.36e-04
Interleukin-10 signaling 17 1.55e-02 0.339000 5.48e-02
Beta-catenin phosphorylation cascade 17 1.56e-02 0.339000 5.48e-02
Signaling by FGFR1 in disease 32 9.43e-04 0.338000 7.01e-03
Signaling by ROBO receptors 194 5.76e-16 -0.337000 3.09e-14
Transcriptional regulation of pluripotent stem cells 12 4.31e-02 0.337000 1.16e-01
Vpu mediated degradation of CD4 49 4.70e-05 -0.336000 6.59e-04
Assembly of the pre-replicative complex 59 8.06e-06 -0.336000 1.51e-04
Autodegradation of the E3 ubiquitin ligase COP1 49 4.75e-05 -0.336000 6.59e-04
Purine salvage 13 3.61e-02 -0.336000 1.01e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 47 6.88e-05 -0.336000 8.94e-04
Ephrin signaling 15 2.44e-02 0.336000 7.60e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 43 1.49e-04 0.334000 1.55e-03
Negative regulation of NOTCH4 signaling 53 2.69e-05 -0.333000 4.26e-04
CD209 (DC-SIGN) signaling 17 1.75e-02 0.333000 5.94e-02
Downregulation of TGF-beta receptor signaling 26 3.46e-03 0.331000 1.77e-02
Gastrin-CREB signalling pathway via PKC and MAPK 14 3.23e-02 0.330000 9.37e-02
Misspliced GSK3beta mutants stabilize beta-catenin 15 2.69e-02 0.330000 8.03e-02
S33 mutants of beta-catenin aren’t phosphorylated 15 2.69e-02 0.330000 8.03e-02
S37 mutants of beta-catenin aren’t phosphorylated 15 2.69e-02 0.330000 8.03e-02
S45 mutants of beta-catenin aren’t phosphorylated 15 2.69e-02 0.330000 8.03e-02
T41 mutants of beta-catenin aren’t phosphorylated 15 2.69e-02 0.330000 8.03e-02
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 2.69e-02 0.330000 8.03e-02
Rap1 signalling 13 3.94e-02 0.330000 1.09e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 1.90e-02 -0.329000 6.28e-02
Defective B3GAT3 causes JDSSDHD 12 4.90e-02 0.328000 1.28e-01
CDT1 association with the CDC6:ORC:origin complex 52 4.37e-05 -0.328000 6.36e-04
Signaling by Activin 12 4.96e-02 0.327000 1.29e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 17 1.96e-02 0.327000 6.40e-02
IRAK1 recruits IKK complex 10 7.34e-02 0.327000 1.67e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 7.34e-02 0.327000 1.67e-01
Mitochondrial calcium ion transport 22 8.11e-03 -0.326000 3.43e-02
Pre-NOTCH Processing in Golgi 18 1.71e-02 0.325000 5.83e-02
Uptake and actions of bacterial toxins 23 7.33e-03 0.323000 3.23e-02
Cross-presentation of soluble exogenous antigens (endosomes) 44 2.11e-04 -0.323000 2.05e-03
SCF-beta-TrCP mediated degradation of Emi1 51 6.96e-05 -0.322000 8.94e-04
Synthesis of PIPs at the late endosome membrane 11 6.46e-02 0.322000 1.53e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 7.58e-03 0.322000 3.28e-02
Autodegradation of Cdh1 by Cdh1:APC/C 61 1.45e-05 -0.321000 2.51e-04
Recycling pathway of L1 22 9.27e-03 0.320000 3.84e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1 12 5.49e-02 0.320000 1.38e-01
Role of LAT2/NTAL/LAB on calcium mobilization 12 5.52e-02 0.320000 1.38e-01
DNA Replication Pre-Initiation 71 3.53e-06 -0.318000 7.39e-05
Signaling by EGFR in Cancer 21 1.18e-02 0.318000 4.50e-02
Signaling by Leptin 10 8.26e-02 0.317000 1.83e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 32 1.99e-03 0.316000 1.19e-02
IGF1R signaling cascade 31 2.34e-03 0.316000 1.33e-02
Chondroitin sulfate biosynthesis 15 3.49e-02 0.315000 9.84e-02
AMER1 mutants destabilize the destruction complex 14 4.20e-02 0.314000 1.14e-01
APC truncation mutants have impaired AXIN binding 14 4.20e-02 0.314000 1.14e-01
AXIN missense mutants destabilize the destruction complex 14 4.20e-02 0.314000 1.14e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 4.20e-02 0.314000 1.14e-01
Truncations of AMER1 destabilize the destruction complex 14 4.20e-02 0.314000 1.14e-01
truncated APC mutants destabilize the destruction complex 14 4.20e-02 0.314000 1.14e-01
Ubiquitin-dependent degradation of Cyclin D 49 1.47e-04 -0.314000 1.54e-03
MAPK targets/ Nuclear events mediated by MAP kinases 30 3.01e-03 0.313000 1.58e-02
Signaling by TGF-beta family members 95 1.53e-07 0.312000 4.19e-06
Transcriptional regulation of granulopoiesis 35 1.43e-03 0.312000 9.58e-03
Degradation of DVL 53 9.64e-05 -0.310000 1.15e-03
tRNA processing in the mitochondrion 33 2.08e-03 0.310000 1.23e-02
IRS-mediated signalling 27 5.40e-03 0.309000 2.49e-02
Extra-nuclear estrogen signaling 56 6.25e-05 0.309000 8.38e-04
Hh mutants abrogate ligand secretion 52 1.17e-04 -0.309000 1.29e-03
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 52 1.17e-04 -0.309000 1.29e-03
Uptake and function of anthrax toxins 11 7.62e-02 0.309000 1.72e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 63 2.28e-05 -0.309000 3.66e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 63 2.28e-05 -0.309000 3.66e-04
APC/C:Cdc20 mediated degradation of Securin 61 3.08e-05 -0.309000 4.71e-04
GLI3 is processed to GLI3R by the proteasome 56 6.75e-05 -0.308000 8.94e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 65 1.80e-05 -0.308000 3.08e-04
Non-integrin membrane-ECM interactions 34 1.91e-03 0.308000 1.17e-02
IRS-related events triggered by IGF1R 30 3.62e-03 0.307000 1.83e-02
Endosomal/Vacuolar pathway 10 9.28e-02 0.307000 2.00e-01
RHO GTPases activate PKNs 40 7.88e-04 0.307000 6.01e-03
Signaling by TGF-beta Receptor Complex 70 9.15e-06 0.307000 1.64e-04
MET promotes cell motility 24 9.42e-03 0.306000 3.87e-02
HSF1-dependent transactivation 32 2.75e-03 0.306000 1.50e-02
Regulation of beta-cell development 18 2.51e-02 0.305000 7.73e-02
SUMOylation of intracellular receptors 26 7.23e-03 0.304000 3.20e-02
COPI-independent Golgi-to-ER retrograde traffic 32 3.04e-03 0.303000 1.59e-02
Circadian Clock 64 2.94e-05 0.302000 4.59e-04
Respiratory electron transport 100 1.82e-07 -0.302000 4.67e-06
MET activates RAS signaling 10 9.91e-02 0.301000 2.10e-01
EPHA-mediated growth cone collapse 14 5.15e-02 0.301000 1.32e-01
Hedgehog ligand biogenesis 56 1.01e-04 -0.301000 1.17e-03
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 12 7.16e-02 0.300000 1.64e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 24 1.11e-02 0.300000 4.36e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 65 3.09e-05 -0.299000 4.71e-04
Degradation of GLI2 by the proteasome 56 1.12e-04 -0.299000 1.25e-03
APC/C:Cdc20 mediated degradation of mitotic proteins 64 3.78e-05 -0.298000 5.62e-04
PI3K/AKT Signaling in Cancer 68 2.24e-05 0.297000 3.66e-04
Regulation of ornithine decarboxylase (ODC) 48 3.65e-04 -0.297000 3.26e-03
Interleukin-6 family signaling 19 2.56e-02 0.296000 7.81e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 8.93e-02 0.296000 1.94e-01
tRNA modification in the nucleus and cytosol 40 1.22e-03 -0.296000 8.55e-03
SCF(Skp2)-mediated degradation of p27/p21 54 1.73e-04 -0.296000 1.75e-03
TP53 Regulates Transcription of Death Receptors and Ligands 10 1.06e-01 0.295000 2.21e-01
Switching of origins to a post-replicative state 79 5.94e-06 -0.295000 1.14e-04
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 42 9.49e-04 0.295000 7.01e-03
Translesion synthesis by POLI 17 3.55e-02 -0.295000 9.94e-02
DAP12 interactions 22 1.68e-02 0.295000 5.78e-02
Synthesis of PIPs at the Golgi membrane 15 4.84e-02 0.294000 1.28e-01
GAB1 signalosome 13 6.65e-02 0.294000 1.55e-01
Activated NOTCH1 Transmits Signal to the Nucleus 29 6.22e-03 0.294000 2.83e-02
Apoptotic cleavage of cellular proteins 29 6.31e-03 0.293000 2.86e-02
Stabilization of p53 52 2.70e-04 -0.292000 2.53e-03
TGF-beta receptor signaling activates SMADs 32 4.25e-03 0.292000 2.09e-02
rRNA processing in the mitochondrion 31 5.04e-03 0.291000 2.37e-02
Molecules associated with elastic fibres 23 1.59e-02 0.291000 5.53e-02
Regulation of Apoptosis 50 3.80e-04 -0.291000 3.38e-03
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 44 8.68e-04 0.290000 6.53e-03
Degradation of GLI1 by the proteasome 55 1.98e-04 -0.290000 1.96e-03
ABC transporters in lipid homeostasis 12 8.21e-02 -0.290000 1.82e-01
Tight junction interactions 11 9.62e-02 0.290000 2.06e-01
DNA strand elongation 29 6.98e-03 -0.290000 3.13e-02
Other semaphorin interactions 15 5.24e-02 0.289000 1.33e-01
Interleukin receptor SHC signaling 15 5.30e-02 0.289000 1.34e-01
Interleukin-20 family signaling 14 6.16e-02 0.289000 1.50e-01
Defective B4GALT7 causes EDS, progeroid type 12 8.45e-02 0.288000 1.86e-01
Signaling by FGFR1 39 1.91e-03 0.287000 1.17e-02
VEGFR2 mediated cell proliferation 17 4.06e-02 0.287000 1.12e-01
FGFR1 mutant receptor activation 25 1.33e-02 0.286000 4.92e-02
Generation of second messenger molecules 19 3.10e-02 0.286000 9.11e-02
Insulin receptor signalling cascade 32 5.15e-03 0.286000 2.40e-02
Signaling by EGFR 42 1.37e-03 0.286000 9.39e-03
RAF-independent MAPK1/3 activation 21 2.37e-02 0.285000 7.48e-02
Synthesis of DNA 104 5.59e-07 -0.284000 1.33e-05
NRAGE signals death through JNK 45 1.03e-03 0.283000 7.51e-03
GPVI-mediated activation cascade 19 3.30e-02 0.283000 9.49e-02
CDK-mediated phosphorylation and removal of Cdc6 64 9.39e-05 -0.282000 1.14e-03
Voltage gated Potassium channels 11 1.05e-01 0.282000 2.20e-01
Regulation of IFNG signaling 12 9.09e-02 0.282000 1.97e-01
Signaling by NOTCH2 30 7.74e-03 0.281000 3.32e-02
FCERI mediated MAPK activation 25 1.53e-02 0.280000 5.46e-02
HSF1 activation 25 1.55e-02 0.280000 5.48e-02
Formation of the beta-catenin:TCF transactivating complex 38 2.99e-03 0.278000 1.58e-02
Metabolism of amino acids and derivatives 298 1.67e-16 -0.278000 9.35e-15
Pre-NOTCH Transcription and Translation 41 2.18e-03 0.277000 1.28e-02
Signaling by FGFR3 30 8.79e-03 0.276000 3.65e-02
Surfactant metabolism 10 1.31e-01 -0.276000 2.55e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 106 9.80e-07 -0.275000 2.24e-05
Signaling by FGFR4 32 7.08e-03 0.275000 3.17e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 26 1.52e-02 0.275000 5.46e-02
Nucleotide salvage 20 3.33e-02 -0.275000 9.51e-02
DNA Replication 107 9.23e-07 -0.275000 2.15e-05
CTLA4 inhibitory signaling 17 5.00e-02 0.275000 1.30e-01
Estrogen-dependent gene expression 92 5.68e-06 0.274000 1.13e-04
ESR-mediated signaling 145 1.40e-08 0.273000 4.44e-07
Transcriptional Regulation by E2F6 31 8.49e-03 0.273000 3.56e-02
AKT phosphorylates targets in the cytosol 14 7.71e-02 0.273000 1.73e-01
Laminin interactions 20 3.47e-02 0.273000 9.83e-02
Pre-NOTCH Expression and Processing 57 3.91e-04 0.272000 3.45e-03
Signaling by NOTCH1 70 8.72e-05 0.271000 1.09e-03
G alpha (12/13) signalling events 56 4.55e-04 0.271000 3.84e-03
Extension of Telomeres 28 1.31e-02 -0.271000 4.88e-02
Activation of the pre-replicative complex 24 2.25e-02 -0.269000 7.15e-02
Regulation of APC/C activators between G1/S and early anaphase 71 9.23e-05 -0.269000 1.13e-03
NOD1/2 Signaling Pathway 29 1.24e-02 0.268000 4.68e-02
Signal amplification 19 4.33e-02 0.268000 1.16e-01
VxPx cargo-targeting to cilium 17 5.67e-02 0.267000 1.42e-01
Integrin cell surface interactions 44 2.19e-03 0.267000 1.28e-02
PI3K Cascade 23 2.68e-02 0.267000 8.03e-02
Translesion synthesis by REV1 16 6.60e-02 -0.265000 1.55e-01
Translocation of ZAP-70 to Immunological synapse 10 1.46e-01 0.265000 2.78e-01
Semaphorin interactions 56 6.58e-04 0.263000 5.21e-03
Defective CFTR causes cystic fibrosis 57 6.14e-04 -0.262000 4.98e-03
Interleukin-2 family signaling 26 2.08e-02 0.262000 6.70e-02
Deadenylation of mRNA 25 2.35e-02 0.262000 7.46e-02
rRNA processing 215 4.08e-11 -0.262000 1.68e-09
Insulin processing 18 5.47e-02 0.262000 1.38e-01
DAP12 signaling 20 4.35e-02 0.261000 1.16e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 4.91e-02 0.261000 1.28e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 4.91e-02 0.261000 1.28e-01
Cell-Cell communication 78 7.24e-05 0.260000 9.11e-04
Activation of NF-kappaB in B cells 62 4.08e-04 -0.260000 3.54e-03
Apoptotic execution phase 39 5.03e-03 0.260000 2.37e-02
activated TAK1 mediates p38 MAPK activation 18 5.70e-02 0.259000 1.42e-01
Notch-HLH transcription pathway 28 1.76e-02 0.259000 5.97e-02
Cellular hexose transport 10 1.57e-01 -0.258000 2.94e-01
Degradation of AXIN 52 1.29e-03 -0.258000 8.93e-03
TRAF3-dependent IRF activation pathway 12 1.22e-01 0.258000 2.44e-01
APC/C-mediated degradation of cell cycle proteins 74 1.30e-04 -0.257000 1.41e-03
Regulation of mitotic cell cycle 74 1.30e-04 -0.257000 1.41e-03
Synthesis, secretion, and deacylation of Ghrelin 11 1.40e-01 -0.257000 2.69e-01
Activation of BAD and translocation to mitochondria 14 9.66e-02 0.257000 2.07e-01
Detoxification of Reactive Oxygen Species 27 2.14e-02 -0.256000 6.87e-02
RHO GTPases activate CIT 18 6.02e-02 0.256000 1.47e-01
Gap junction trafficking and regulation 15 8.66e-02 0.256000 1.89e-01
Elastic fibre formation 33 1.15e-02 0.254000 4.43e-02
Resolution of Abasic Sites (AP sites) 37 7.87e-03 -0.253000 3.35e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 60 7.34e-04 -0.252000 5.66e-03
Cargo concentration in the ER 25 3.00e-02 0.251000 8.86e-02
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 24 3.37e-02 0.251000 9.55e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 52 1.79e-03 -0.250000 1.13e-02
Interleukin-37 signaling 17 7.39e-02 0.250000 1.68e-01
Sema3A PAK dependent Axon repulsion 14 1.06e-01 0.250000 2.21e-01
Metabolism of polyamines 56 1.26e-03 -0.249000 8.79e-03
Formation of the Early Elongation Complex 30 1.83e-02 -0.249000 6.11e-02
Formation of the HIV-1 Early Elongation Complex 30 1.83e-02 -0.249000 6.11e-02
Depolymerisation of the Nuclear Lamina 12 1.36e-01 0.249000 2.62e-01
PCNA-Dependent Long Patch Base Excision Repair 20 5.47e-02 -0.248000 1.38e-01
Constitutive Signaling by Aberrant PI3K in Cancer 42 5.49e-03 0.248000 2.52e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 15 9.73e-02 0.247000 2.07e-01
Telomere C-strand (Lagging Strand) Synthesis 23 4.05e-02 -0.247000 1.11e-01
Signalling to ERKs 30 1.94e-02 0.247000 6.37e-02
Mitochondrial protein import 58 1.16e-03 -0.247000 8.25e-03
Activated NTRK2 signals through FRS2 and FRS3 10 1.78e-01 0.246000 3.22e-01
Interconversion of nucleotide di- and triphosphates 23 4.24e-02 -0.245000 1.14e-01
Downregulation of ERBB2:ERBB3 signaling 12 1.43e-01 -0.244000 2.73e-01
PKA-mediated phosphorylation of CREB 17 8.15e-02 0.244000 1.81e-01
Diseases of carbohydrate metabolism 28 2.55e-02 -0.244000 7.81e-02
Toll Like Receptor 4 (TLR4) Cascade 107 1.33e-05 0.244000 2.35e-04
SHC1 events in ERBB4 signaling 10 1.82e-01 0.244000 3.25e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 54 1.99e-03 -0.243000 1.19e-02
NIK–>noncanonical NF-kB signaling 56 1.70e-03 -0.243000 1.08e-02
ECM proteoglycans 34 1.46e-02 0.242000 5.30e-02
Synaptic adhesion-like molecules 12 1.47e-01 -0.242000 2.79e-01
Dectin-1 mediated noncanonical NF-kB signaling 57 1.63e-03 -0.241000 1.06e-02
Toll Like Receptor 9 (TLR9) Cascade 84 1.38e-04 0.241000 1.48e-03
Diseases associated with the TLR signaling cascade 18 7.73e-02 0.241000 1.73e-01
Diseases of Immune System 18 7.73e-02 0.241000 1.73e-01
Regulation of RUNX3 expression and activity 52 2.81e-03 -0.240000 1.51e-02
Diseases associated with glycosaminoglycan metabolism 29 2.62e-02 0.239000 7.99e-02
Golgi Associated Vesicle Biogenesis 50 3.82e-03 0.237000 1.90e-02
RUNX2 regulates bone development 27 3.34e-02 0.237000 9.51e-02
Endogenous sterols 17 9.17e-02 0.236000 1.98e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 1.97e-01 -0.236000 3.43e-01
Repression of WNT target genes 12 1.58e-01 0.236000 2.95e-01
MyD88 dependent cascade initiated on endosome 81 2.51e-04 0.235000 2.38e-03
Toll Like Receptor 7/8 (TLR7/8) Cascade 81 2.51e-04 0.235000 2.38e-03
p53-Dependent G1 DNA Damage Response 58 1.95e-03 -0.235000 1.18e-02
p53-Dependent G1/S DNA damage checkpoint 58 1.95e-03 -0.235000 1.18e-02
B-WICH complex positively regulates rRNA expression 40 1.01e-02 0.235000 4.07e-02
MyD88-independent TLR4 cascade 88 1.41e-04 0.235000 1.49e-03
TRIF(TICAM1)-mediated TLR4 signaling 88 1.41e-04 0.235000 1.49e-03
Regulation of IFNA signaling 11 1.78e-01 0.235000 3.21e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 2.36e-03 0.233000 1.33e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 2.36e-03 0.233000 1.33e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 2.36e-03 0.233000 1.33e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 2.36e-03 0.233000 1.33e-02
Signaling by NOTCH1 in Cancer 57 2.36e-03 0.233000 1.33e-02
mRNA Splicing - Minor Pathway 50 4.44e-03 -0.233000 2.15e-02
MET activates PTK2 signaling 14 1.33e-01 0.232000 2.58e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 83 2.77e-04 0.231000 2.53e-03
Toll Like Receptor 2 (TLR2) Cascade 83 2.77e-04 0.231000 2.53e-03
Toll Like Receptor TLR1:TLR2 Cascade 83 2.77e-04 0.231000 2.53e-03
Toll Like Receptor TLR6:TLR2 Cascade 83 2.77e-04 0.231000 2.53e-03
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 80 3.58e-04 0.231000 3.22e-03
Signaling by NTRK1 (TRKA) 71 8.00e-04 0.230000 6.06e-03
ABC transporter disorders 68 1.04e-03 -0.230000 7.51e-03
Transcriptional Regulation by MECP2 44 8.42e-03 0.230000 3.55e-02
Nuclear Events (kinase and transcription factor activation) 24 5.18e-02 0.229000 1.33e-01
Signaling by NTRK2 (TRKB) 21 6.94e-02 0.229000 1.61e-01
eNOS activation 11 1.89e-01 0.229000 3.34e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 54 3.67e-03 0.229000 1.85e-02
BBSome-mediated cargo-targeting to cilium 19 8.47e-02 -0.229000 1.86e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 26 4.38e-02 0.229000 1.17e-01
Signalling to RAS 17 1.04e-01 0.228000 2.18e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 1.72e-01 -0.228000 3.14e-01
PKA activation 15 1.27e-01 0.228000 2.50e-01
Regulation of TP53 Activity through Association with Co-factors 11 1.91e-01 0.227000 3.37e-01
Antimicrobial peptides 10 2.13e-01 -0.227000 3.63e-01
RIP-mediated NFkB activation via ZBP1 15 1.28e-01 0.227000 2.52e-01
Activation of GABAB receptors 23 5.98e-02 0.227000 1.47e-01
GABA B receptor activation 23 5.98e-02 0.227000 1.47e-01
Signaling by NOTCH3 44 9.53e-03 0.226000 3.91e-02
Sema4D induced cell migration and growth-cone collapse 19 8.82e-02 0.226000 1.92e-01
Metabolism of nitric oxide: eNOS activation and regulation 15 1.31e-01 0.225000 2.55e-01
Signaling by cytosolic FGFR1 fusion mutants 18 9.94e-02 0.224000 2.10e-01
MyD88 cascade initiated on plasma membrane 78 6.63e-04 0.223000 5.21e-03
Toll Like Receptor 10 (TLR10) Cascade 78 6.63e-04 0.223000 5.21e-03
Toll Like Receptor 5 (TLR5) Cascade 78 6.63e-04 0.223000 5.21e-03
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 7.01e-02 0.223000 1.62e-01
Deactivation of the beta-catenin transactivating complex 38 1.80e-02 0.222000 6.06e-02
G1/S DNA Damage Checkpoints 60 2.99e-03 -0.222000 1.58e-02
Peptide ligand-binding receptors 44 1.11e-02 0.221000 4.36e-02
G alpha (q) signalling events 85 4.43e-04 0.221000 3.77e-03
Nucleobase biosynthesis 15 1.40e-01 -0.220000 2.69e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 14 1.54e-01 0.220000 2.89e-01
Processive synthesis on the C-strand of the telomere 11 2.06e-01 -0.220000 3.56e-01
G alpha (z) signalling events 30 3.74e-02 0.220000 1.04e-01
Peroxisomal lipid metabolism 24 6.27e-02 -0.220000 1.52e-01
RHO GTPases Activate ROCKs 19 9.82e-02 0.219000 2.08e-01
Cell junction organization 50 7.40e-03 0.219000 3.25e-02
Processive synthesis on the lagging strand 15 1.42e-01 -0.219000 2.73e-01
ABC-family proteins mediated transport 88 3.96e-04 -0.219000 3.46e-03
Lagging Strand Synthesis 20 9.18e-02 -0.218000 1.98e-01
Asymmetric localization of PCP proteins 60 3.55e-03 -0.218000 1.81e-02
RNA Pol II CTD phosphorylation and interaction with CE 24 6.52e-02 -0.217000 1.53e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 24 6.52e-02 -0.217000 1.53e-01
EGFR downregulation 25 6.05e-02 0.217000 1.48e-01
CRMPs in Sema3A signaling 14 1.61e-01 0.216000 3.00e-01
Toll Like Receptor 3 (TLR3) Cascade 86 5.35e-04 0.216000 4.50e-03
Nuclear Receptor transcription pathway 41 1.67e-02 0.216000 5.78e-02
Transcriptional activation of mitochondrial biogenesis 52 7.13e-03 0.216000 3.18e-02
COPII-mediated vesicle transport 60 3.95e-03 0.215000 1.96e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 32 3.52e-02 0.215000 9.88e-02
ZBP1(DAI) mediated induction of type I IFNs 18 1.14e-01 0.215000 2.34e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 24 6.85e-02 0.215000 1.59e-01
TRAF6 mediated IRF7 activation 14 1.64e-01 0.215000 3.03e-01
SIRT1 negatively regulates rRNA expression 18 1.15e-01 0.214000 2.36e-01
Translesion synthesis by POLK 17 1.26e-01 -0.214000 2.49e-01
CD28 dependent PI3K/Akt signaling 15 1.51e-01 0.214000 2.85e-01
Intrinsic Pathway for Apoptosis 47 1.13e-02 0.214000 4.43e-02
SUMOylation of transcription cofactors 43 1.55e-02 0.214000 5.48e-02
Cell surface interactions at the vascular wall 76 1.32e-03 0.213000 9.12e-03
Signaling by Nuclear Receptors 202 1.85e-07 0.213000 4.67e-06
Oncogenic MAPK signaling 58 5.03e-03 0.213000 2.37e-02
Mitochondrial Fatty Acid Beta-Oxidation 29 4.80e-02 -0.212000 1.27e-01
Activation of gene expression by SREBF (SREBP) 41 1.88e-02 0.212000 6.21e-02
Signaling by VEGF 88 5.95e-04 0.212000 4.86e-03
Dual Incision in GG-NER 38 2.40e-02 -0.212000 7.52e-02
Prolonged ERK activation events 12 2.05e-01 0.211000 3.54e-01
Class A/1 (Rhodopsin-like receptors) 72 1.96e-03 0.211000 1.18e-02
Signaling by high-kinase activity BRAF mutants 27 5.78e-02 0.211000 1.43e-01
NOTCH1 Intracellular Domain Regulates Transcription 46 1.37e-02 0.210000 5.03e-02
Purine ribonucleoside monophosphate biosynthesis 12 2.08e-01 -0.210000 3.56e-01
ERK/MAPK targets 21 9.61e-02 0.210000 2.06e-01
RHO GTPases activate PAKs 20 1.05e-01 0.209000 2.20e-01
Toll-like Receptor Cascades 122 6.86e-05 0.209000 8.94e-04
Phosphorylation of CD3 and TCR zeta chains 13 1.93e-01 0.209000 3.39e-01
Myogenesis 25 7.12e-02 0.209000 1.64e-01
Transport of vitamins, nucleosides, and related molecules 28 5.70e-02 -0.208000 1.42e-01
RUNX2 regulates osteoblast differentiation 21 9.95e-02 0.208000 2.10e-01
SUMOylation of transcription factors 15 1.64e-01 0.207000 3.03e-01
APC-Cdc20 mediated degradation of Nek2A 21 1.01e-01 -0.207000 2.13e-01
Signaling by WNT in cancer 29 5.44e-02 0.206000 1.38e-01
Glycogen storage diseases 13 1.99e-01 -0.206000 3.46e-01
Interaction between L1 and Ankyrins 17 1.44e-01 0.205000 2.74e-01
Signaling by MET 57 7.54e-03 0.205000 3.28e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 1.14e-01 0.204000 2.34e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 1.71e-01 0.204000 3.12e-01
PKMTs methylate histone lysines 37 3.20e-02 0.204000 9.30e-02
Rho GTPase cycle 113 1.88e-04 0.204000 1.88e-03
Protein methylation 15 1.73e-01 -0.203000 3.16e-01
Factors involved in megakaryocyte development and platelet production 90 9.23e-04 0.202000 6.90e-03
Regulation of MECP2 expression and activity 28 6.44e-02 0.202000 1.53e-01
VEGFA-VEGFR2 Pathway 81 1.72e-03 0.202000 1.09e-02
PKA activation in glucagon signalling 15 1.79e-01 0.201000 3.22e-01
Diseases associated with N-glycosylation of proteins 16 1.65e-01 -0.201000 3.04e-01
PD-1 signaling 14 1.98e-01 0.199000 3.44e-01
SLBP independent Processing of Histone Pre-mRNAs 10 2.77e-01 -0.198000 4.39e-01
Transcriptional regulation of white adipocyte differentiation 77 2.66e-03 0.198000 1.48e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 9.36e-02 -0.198000 2.01e-01
MAP kinase activation 61 7.63e-03 0.198000 3.29e-02
CD28 co-stimulation 23 1.01e-01 0.197000 2.13e-01
Fanconi Anemia Pathway 29 6.59e-02 -0.197000 1.55e-01
Positive epigenetic regulation of rRNA expression 55 1.15e-02 0.197000 4.43e-02
Plasma lipoprotein remodeling 15 1.87e-01 0.197000 3.31e-01
DCC mediated attractive signaling 13 2.20e-01 0.197000 3.70e-01
Downstream signaling events of B Cell Receptor (BCR) 75 3.34e-03 -0.196000 1.72e-02
Negative regulation of the PI3K/AKT network 74 3.56e-03 0.196000 1.81e-02
Diseases associated with glycosylation precursor biosynthesis 18 1.51e-01 -0.196000 2.85e-01
Phase II - Conjugation of compounds 55 1.25e-02 -0.195000 4.69e-02
Regulation of innate immune responses to cytosolic DNA 12 2.43e-01 -0.195000 4.00e-01
Degradation of the extracellular matrix 59 1.00e-02 0.194000 4.05e-02
Regulation of TP53 Activity through Acetylation 30 6.64e-02 0.194000 1.55e-01
Negative regulation of FGFR2 signaling 22 1.16e-01 0.194000 2.37e-01
Initiation of Nuclear Envelope Reformation 12 2.47e-01 0.193000 4.04e-01
Nuclear Envelope Reassembly 12 2.47e-01 0.193000 4.04e-01
Phase 2 - plateau phase 13 2.29e-01 -0.193000 3.82e-01
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 107 5.80e-04 0.193000 4.77e-03
Formation of TC-NER Pre-Incision Complex 50 1.85e-02 -0.193000 6.15e-02
Activation of HOX genes during differentiation 64 7.78e-03 0.192000 3.32e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 64 7.78e-03 0.192000 3.32e-02
Gap junction trafficking 13 2.30e-01 0.192000 3.83e-01
Fcgamma receptor (FCGR) dependent phagocytosis 72 4.81e-03 0.192000 2.30e-02
L1CAM interactions 71 5.25e-03 0.192000 2.44e-02
PPARA activates gene expression 105 7.03e-04 0.192000 5.49e-03
MAP2K and MAPK activation 31 6.50e-02 0.192000 1.53e-01
Cell death signalling via NRAGE, NRIF and NADE 61 9.99e-03 0.191000 4.05e-02
Negative regulation of FGFR4 signaling 22 1.22e-01 0.191000 2.43e-01
Removal of the Flap Intermediate 14 2.19e-01 -0.190000 3.70e-01
The citric acid (TCA) cycle and respiratory electron transport 153 5.23e-05 -0.190000 7.10e-04
PRC2 methylates histones and DNA 22 1.24e-01 0.190000 2.46e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 12 2.56e-01 -0.189000 4.13e-01
Growth hormone receptor signaling 18 1.67e-01 0.188000 3.06e-01
Signaling by NTRKs 87 2.49e-03 0.188000 1.40e-02
Extracellular matrix organization 192 7.56e-06 0.188000 1.44e-04
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 68 7.48e-03 0.188000 3.27e-02
IKK complex recruitment mediated by RIP1 20 1.48e-01 0.187000 2.81e-01
Membrane binding and targetting of GAG proteins 13 2.44e-01 -0.187000 4.02e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 2.44e-01 -0.187000 4.02e-01
p75 NTR receptor-mediated signalling 77 4.74e-03 0.186000 2.27e-02
Infectious disease 340 4.08e-09 -0.186000 1.40e-07
Blood group systems biosynthesis 11 2.86e-01 0.186000 4.51e-01
Nonhomologous End-Joining (NHEJ) 37 5.06e-02 0.186000 1.31e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 2.46e-01 0.186000 4.04e-01
Negative regulation of FGFR1 signaling 23 1.24e-01 0.186000 2.46e-01
Post-translational modification: synthesis of GPI-anchored proteins 45 3.20e-02 -0.185000 9.30e-02
Sema4D in semaphorin signaling 23 1.25e-01 0.185000 2.48e-01
DNA Damage Recognition in GG-NER 37 5.21e-02 -0.185000 1.33e-01
Death Receptor Signalling 118 5.49e-04 0.184000 4.55e-03
Negative regulation of FGFR3 signaling 20 1.54e-01 0.184000 2.89e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 24 1.19e-01 -0.184000 2.39e-01
Signal Transduction 1544 1.54e-32 0.184000 1.90e-29
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.92e-01 0.184000 4.58e-01
mRNA Capping 26 1.05e-01 -0.184000 2.20e-01
SUMOylation 153 9.19e-05 0.183000 1.13e-03
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 5.72e-02 0.183000 1.42e-01
DNA methylation 12 2.75e-01 0.182000 4.36e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 22 1.41e-01 -0.181000 2.71e-01
SHC1 events in ERBB2 signaling 18 1.83e-01 0.181000 3.26e-01
Meiotic synapsis 33 7.20e-02 0.181000 1.65e-01
Cytokine Signaling in Immune system 582 1.56e-13 0.180000 7.39e-12
Metabolism of nucleotides 84 4.38e-03 -0.180000 2.14e-02
Signaling by BRAF and RAF fusions 54 2.23e-02 0.180000 7.09e-02
Interferon alpha/beta signaling 47 3.31e-02 0.180000 9.50e-02
Netrin-1 signaling 39 5.24e-02 0.180000 1.33e-01
Removal of the Flap Intermediate from the C-strand 10 3.26e-01 -0.179000 4.96e-01
Interleukin-17 signaling 65 1.25e-02 0.179000 4.69e-02
Regulation of actin dynamics for phagocytic cup formation 52 2.55e-02 0.179000 7.81e-02
Regulation of RAS by GAPs 63 1.44e-02 -0.178000 5.24e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 36 6.51e-02 -0.178000 1.53e-01
HIV Transcription Elongation 36 6.51e-02 -0.178000 1.53e-01
Tat-mediated elongation of the HIV-1 transcript 36 6.51e-02 -0.178000 1.53e-01
Branched-chain amino acid catabolism 18 1.93e-01 0.177000 3.39e-01
Host Interactions of HIV factors 115 1.07e-03 -0.177000 7.75e-03
Signaling by the B Cell Receptor (BCR) 96 2.81e-03 -0.177000 1.51e-02
Early Phase of HIV Life Cycle 13 2.71e-01 -0.176000 4.31e-01
Oncogene Induced Senescence 30 9.74e-02 0.175000 2.07e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 3.29e-02 0.174000 9.48e-02
DNA Double Strand Break Response 45 4.35e-02 0.174000 1.16e-01
Signaling by ERBB2 42 5.11e-02 0.174000 1.32e-01
SUMO E3 ligases SUMOylate target proteins 147 2.79e-04 0.174000 2.53e-03
Glutamate and glutamine metabolism 12 2.97e-01 0.174000 4.65e-01
TNFR2 non-canonical NF-kB pathway 71 1.14e-02 -0.174000 4.43e-02
trans-Golgi Network Vesicle Budding 64 1.63e-02 0.174000 5.65e-02
Folding of actin by CCT/TriC 10 3.42e-01 0.174000 5.14e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 44 4.66e-02 0.173000 1.24e-01
Signaling by Rho GTPases 303 2.30e-07 0.173000 5.67e-06
FCERI mediated NF-kB activation 73 1.05e-02 -0.173000 4.19e-02
Metabolism of porphyrins 14 2.63e-01 -0.173000 4.22e-01
Signaling by Interleukins 313 1.63e-07 0.173000 4.39e-06
Reduction of cytosolic Ca++ levels 10 3.47e-01 0.172000 5.19e-01
Cellular Senescence 125 9.78e-04 0.171000 7.18e-03
Mitochondrial tRNA aminoacylation 21 1.77e-01 -0.170000 3.21e-01
Platelet activation, signaling and aggregation 176 1.02e-04 0.170000 1.17e-03
Mitochondrial biogenesis 74 1.15e-02 0.170000 4.43e-02
Signaling by Receptor Tyrosine Kinases 352 5.70e-08 0.169000 1.64e-06
Role of phospholipids in phagocytosis 16 2.42e-01 0.169000 4.00e-01
GABA receptor activation 25 1.44e-01 0.169000 2.74e-01
Vasopressin regulates renal water homeostasis via Aquaporins 30 1.10e-01 0.168000 2.29e-01
APC/C:Cdc20 mediated degradation of Cyclin B 20 1.95e-01 -0.168000 3.40e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 18 2.19e-01 0.167000 3.70e-01
Neurodegenerative Diseases 18 2.19e-01 0.167000 3.70e-01
p38MAPK events 13 2.97e-01 0.167000 4.65e-01
Synthesis of PIPs at the plasma membrane 46 5.06e-02 0.167000 1.31e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 26 1.41e-01 0.167000 2.71e-01
NR1H2 and NR1H3-mediated signaling 38 7.68e-02 0.166000 1.73e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 74 1.37e-02 -0.166000 5.05e-02
Regulation of PTEN stability and activity 66 2.03e-02 -0.165000 6.57e-02
UCH proteinases 82 9.72e-03 -0.165000 3.97e-02
Cellular response to hypoxia 67 1.95e-02 -0.165000 6.40e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 14 2.87e-01 0.164000 4.52e-01
Dual incision in TC-NER 61 2.67e-02 -0.164000 8.03e-02
Chemokine receptors bind chemokines 13 3.05e-01 0.164000 4.72e-01
Hemostasis 382 4.47e-08 0.164000 1.31e-06
G2/M DNA damage checkpoint 57 3.29e-02 0.163000 9.48e-02
PCP/CE pathway 82 1.06e-02 -0.163000 4.20e-02
EPH-Ephrin signaling 72 1.70e-02 0.163000 5.82e-02
Nicotinate metabolism 24 1.68e-01 -0.163000 3.08e-01
VEGFR2 mediated vascular permeability 22 1.87e-01 0.163000 3.31e-01
Translesion Synthesis by POLH 19 2.21e-01 -0.162000 3.72e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 3.32e-01 0.162000 5.04e-01
Regulation of RUNX2 expression and activity 66 2.37e-02 -0.161000 7.48e-02
Signaling by FGFR in disease 49 5.16e-02 0.161000 1.32e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 17 2.52e-01 -0.160000 4.10e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 17 2.52e-01 -0.160000 4.10e-01
A tetrasaccharide linker sequence is required for GAG synthesis 16 2.68e-01 0.160000 4.29e-01
Regulation of TP53 Degradation 30 1.31e-01 0.160000 2.55e-01
Regulation of TP53 Expression and Degradation 30 1.31e-01 0.160000 2.55e-01
mRNA decay by 3’ to 5’ exoribonuclease 16 2.69e-01 -0.160000 4.29e-01
Degradation of cysteine and homocysteine 13 3.20e-01 -0.159000 4.90e-01
Costimulation by the CD28 family 47 5.89e-02 0.159000 1.45e-01
Chromatin modifying enzymes 202 9.82e-05 0.159000 1.15e-03
Chromatin organization 202 9.82e-05 0.159000 1.15e-03
Glycogen breakdown (glycogenolysis) 14 3.03e-01 0.159000 4.69e-01
Signaling by Non-Receptor Tyrosine Kinases 46 6.23e-02 0.159000 1.51e-01
Signaling by PTK6 46 6.23e-02 0.159000 1.51e-01
GABA synthesis, release, reuptake and degradation 10 3.84e-01 0.159000 5.62e-01
Cyclin A:Cdk2-associated events at S phase entry 77 1.75e-02 -0.157000 5.94e-02
Phase 0 - rapid depolarisation 25 1.75e-01 -0.157000 3.18e-01
Sphingolipid de novo biosynthesis 33 1.20e-01 0.157000 2.41e-01
Global Genome Nucleotide Excision Repair (GG-NER) 80 1.56e-02 -0.156000 5.48e-02
Binding and Uptake of Ligands by Scavenger Receptors 28 1.52e-01 0.156000 2.86e-01
Ca2+ pathway 47 6.37e-02 0.156000 1.53e-01
Hedgehog ‘on’ state 76 1.86e-02 -0.156000 6.16e-02
Gap-filling DNA repair synthesis and ligation in TC-NER 60 3.65e-02 -0.156000 1.01e-01
Protein localization 147 1.10e-03 -0.156000 7.90e-03
Neurexins and neuroligins 31 1.33e-01 0.156000 2.58e-01
Class B/2 (Secretin family receptors) 42 8.16e-02 -0.155000 1.81e-01
RHO GTPase Effectors 199 1.64e-04 0.155000 1.67e-03
O-linked glycosylation of mucins 29 1.49e-01 0.155000 2.82e-01
Condensation of Prophase Chromosomes 21 2.20e-01 0.155000 3.70e-01
RHO GTPases Activate Formins 92 1.05e-02 0.155000 4.19e-02
TNFR1-induced NFkappaB signaling pathway 24 1.90e-01 0.154000 3.35e-01
Epigenetic regulation of gene expression 92 1.06e-02 0.154000 4.20e-02
Platelet sensitization by LDL 15 3.01e-01 0.154000 4.68e-01
Other interleukin signaling 18 2.57e-01 0.154000 4.15e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 13 3.37e-01 0.154000 5.08e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 4.00e-01 0.154000 5.79e-01
Cytosolic tRNA aminoacylation 24 1.92e-01 -0.154000 3.38e-01
Cell-cell junction organization 26 1.80e-01 0.152000 3.23e-01
Diseases of signal transduction 307 5.14e-06 0.152000 1.06e-04
Cyclin E associated events during G1/S transition 75 2.38e-02 -0.151000 7.48e-02
Oxidative Stress Induced Senescence 70 2.90e-02 0.151000 8.58e-02
Listeria monocytogenes entry into host cells 17 2.82e-01 0.151000 4.46e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 36 1.18e-01 0.150000 2.39e-01
Signaling by RAS mutants 36 1.18e-01 0.150000 2.39e-01
Signaling by moderate kinase activity BRAF mutants 36 1.18e-01 0.150000 2.39e-01
Signaling downstream of RAS mutants 36 1.18e-01 0.150000 2.39e-01
Resolution of Sister Chromatid Cohesion 76 2.38e-02 0.150000 7.48e-02
G1/S Transition 111 6.43e-03 -0.150000 2.91e-02
ER-Phagosome pathway 75 2.54e-02 -0.149000 7.81e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs 74 2.78e-02 -0.148000 8.26e-02
Assembly Of The HIV Virion 15 3.21e-01 -0.148000 4.91e-01
Ovarian tumor domain proteases 34 1.36e-01 0.148000 2.62e-01
RHO GTPases Activate NADPH Oxidases 13 3.57e-01 -0.148000 5.32e-01
DNA Damage/Telomere Stress Induced Senescence 33 1.43e-01 0.148000 2.73e-01
FCERI mediated Ca+2 mobilization 21 2.42e-01 0.147000 4.00e-01
S Phase 139 2.78e-03 -0.147000 1.50e-02
Platelet degranulation 91 1.54e-02 0.147000 5.48e-02
Formation of HIV elongation complex in the absence of HIV Tat 38 1.18e-01 -0.147000 2.39e-01
Signaling by Insulin receptor 49 7.62e-02 0.147000 1.72e-01
Transcription of E2F targets under negative control by DREAM complex 15 3.28e-01 0.146000 4.99e-01
Serotonin Neurotransmitter Release Cycle 10 4.25e-01 0.146000 5.92e-01
TRAF6 mediated NF-kB activation 21 2.50e-01 0.145000 4.09e-01
Base Excision Repair 52 7.14e-02 -0.145000 1.64e-01
Peroxisomal protein import 55 6.43e-02 -0.144000 1.53e-01
RAB GEFs exchange GTP for GDP on RABs 81 2.49e-02 0.144000 7.69e-02
Arachidonic acid metabolism 24 2.22e-01 -0.144000 3.72e-01
Metabolism of RNA 664 3.17e-10 -0.144000 1.15e-08
Regulation of PTEN gene transcription 59 5.58e-02 0.144000 1.40e-01
Termination of translesion DNA synthesis 29 1.81e-01 -0.144000 3.23e-01
Formation of Incision Complex in GG-NER 41 1.12e-01 -0.144000 2.30e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 4.11e-01 0.143000 5.84e-01
Processing and activation of SUMO 10 4.33e-01 0.143000 6.00e-01
Ion transport by P-type ATPases 39 1.23e-01 0.143000 2.44e-01
NCAM signaling for neurite out-growth 42 1.09e-01 0.143000 2.27e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 4.38e-01 0.142000 6.03e-01
Mitotic Prophase 85 2.43e-02 0.141000 7.58e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 1.67e-01 0.141000 3.06e-01
G0 and Early G1 18 2.99e-01 0.141000 4.66e-01
Antiviral mechanism by IFN-stimulated genes 76 3.34e-02 0.141000 9.51e-02
Meiosis 50 8.45e-02 0.141000 1.86e-01
Amino acid transport across the plasma membrane 21 2.63e-01 -0.141000 4.23e-01
Aquaporin-mediated transport 31 1.77e-01 0.140000 3.21e-01
Prostacyclin signalling through prostacyclin receptor 10 4.44e-01 -0.140000 6.07e-01
Amyloid fiber formation 41 1.22e-01 0.140000 2.43e-01
Heme biosynthesis 10 4.45e-01 -0.139000 6.08e-01
RIPK1-mediated regulated necrosis 14 3.69e-01 0.139000 5.45e-01
Regulated Necrosis 14 3.69e-01 0.139000 5.45e-01
Formation of Fibrin Clot (Clotting Cascade) 18 3.10e-01 0.138000 4.78e-01
Nitric oxide stimulates guanylate cyclase 17 3.24e-01 0.138000 4.95e-01
Integration of energy metabolism 77 3.62e-02 0.138000 1.01e-01
Response to elevated platelet cytosolic Ca2+ 94 2.09e-02 0.138000 6.74e-02
DARPP-32 events 22 2.66e-01 0.137000 4.27e-01
Chromosome Maintenance 61 6.51e-02 -0.137000 1.53e-01
Regulation of TP53 Activity 143 4.89e-03 0.137000 2.33e-02
mRNA Splicing 183 1.50e-03 -0.136000 9.90e-03
Acyl chain remodelling of PS 10 4.56e-01 -0.136000 6.18e-01
RNA Polymerase II Transcription Termination 63 6.28e-02 -0.136000 1.52e-01
Signal regulatory protein family interactions 11 4.37e-01 0.135000 6.03e-01
Glucagon-type ligand receptors 14 3.83e-01 -0.135000 5.61e-01
PI Metabolism 72 4.85e-02 0.135000 1.28e-01
Telomere Maintenance 43 1.29e-01 -0.134000 2.53e-01
Formation of tubulin folding intermediates by CCT/TriC 19 3.15e-01 0.133000 4.85e-01
Hedgehog ‘off’ state 93 2.68e-02 -0.133000 8.03e-02
Signaling by FGFR2 in disease 30 2.09e-01 0.133000 3.58e-01
Dopamine Neurotransmitter Release Cycle 15 3.75e-01 0.132000 5.53e-01
Signaling by FGFR 66 6.32e-02 0.132000 1.53e-01
Plasma lipoprotein assembly, remodeling, and clearance 48 1.15e-01 0.132000 2.35e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 4.50e-01 -0.131000 6.13e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 67 6.34e-02 0.131000 1.53e-01
Amplification of signal from the kinetochores 67 6.34e-02 0.131000 1.53e-01
ISG15 antiviral mechanism 70 5.97e-02 0.130000 1.47e-01
Signaling by NTRK3 (TRKC) 15 3.83e-01 0.130000 5.61e-01
Intra-Golgi traffic 40 1.56e-01 0.130000 2.92e-01
rRNA modification in the nucleus and cytosol 57 9.09e-02 -0.130000 1.97e-01
Collagen degradation 19 3.29e-01 0.129000 4.99e-01
Pausing and recovery of Tat-mediated HIV elongation 26 2.54e-01 -0.129000 4.12e-01
Tat-mediated HIV elongation arrest and recovery 26 2.54e-01 -0.129000 4.12e-01
Alpha-protein kinase 1 signaling pathway 11 4.59e-01 -0.129000 6.21e-01
N-glycan antennae elongation in the medial/trans-Golgi 18 3.44e-01 0.129000 5.17e-01
Transport to the Golgi and subsequent modification 147 7.22e-03 0.129000 3.20e-02
Budding and maturation of HIV virion 25 2.68e-01 -0.128000 4.29e-01
Activation of kainate receptors upon glutamate binding 19 3.36e-01 -0.127000 5.08e-01
Nucleotide Excision Repair 105 2.47e-02 -0.127000 7.66e-02
Disorders of transmembrane transporters 127 1.38e-02 -0.127000 5.06e-02
Pink/Parkin Mediated Mitophagy 20 3.27e-01 -0.127000 4.98e-01
TICAM1, RIP1-mediated IKK complex recruitment 18 3.53e-01 0.126000 5.27e-01
Glycosaminoglycan metabolism 85 4.49e-02 0.126000 1.20e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 27 2.58e-01 0.126000 4.15e-01
tRNA Aminoacylation 42 1.60e-01 -0.125000 2.97e-01
ERBB2 Regulates Cell Motility 11 4.73e-01 -0.125000 6.35e-01
MAPK family signaling cascades 219 1.48e-03 0.125000 9.82e-03
Cyclin D associated events in G1 39 1.80e-01 0.124000 3.23e-01
G1 Phase 39 1.80e-01 0.124000 3.23e-01
Phosphorylation of the APC/C 17 3.78e-01 -0.123000 5.56e-01
RHO GTPases Activate WASPs and WAVEs 34 2.13e-01 0.123000 3.63e-01
Immune System 1399 2.95e-14 0.123000 1.46e-12
Gap junction degradation 10 5.00e-01 0.123000 6.59e-01
mRNA 3’-end processing 54 1.18e-01 -0.123000 2.39e-01
cGMP effects 11 4.83e-01 -0.122000 6.45e-01
EPH-ephrin mediated repulsion of cells 33 2.24e-01 0.122000 3.75e-01
Packaging Of Telomere Ends 15 4.13e-01 0.122000 5.84e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 3.99e-01 -0.122000 5.79e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 68 8.27e-02 -0.122000 1.83e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 2.92e-01 0.122000 4.59e-01
TP53 Regulates Transcription of Cell Cycle Genes 41 1.78e-01 0.122000 3.21e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 28 2.65e-01 -0.122000 4.26e-01
ER to Golgi Anterograde Transport 124 1.96e-02 0.122000 6.40e-02
Signaling by FGFR2 57 1.14e-01 0.121000 2.34e-01
SUMOylation of DNA methylation proteins 15 4.17e-01 0.121000 5.87e-01
SUMOylation of chromatin organization proteins 55 1.21e-01 0.121000 2.43e-01
Vesicle-mediated transport 537 2.04e-06 0.121000 4.42e-05
Synthesis of IP2, IP, and Ins in the cytosol 13 4.54e-01 0.120000 6.17e-01
Processing of Capped Intronless Pre-mRNA 28 2.75e-01 -0.119000 4.37e-01
Spry regulation of FGF signaling 16 4.11e-01 0.119000 5.84e-01
Activation of ATR in response to replication stress 29 2.69e-01 -0.119000 4.29e-01
Metal ion SLC transporters 18 3.85e-01 0.118000 5.62e-01
Transcriptional regulation by RUNX1 163 9.39e-03 0.118000 3.87e-02
ADP signalling through P2Y purinoceptor 1 14 4.44e-01 0.118000 6.07e-01
Nuclear Envelope Breakdown 47 1.62e-01 0.118000 3.00e-01
Kinesins 24 3.19e-01 0.118000 4.90e-01
Degradation of beta-catenin by the destruction complex 79 7.20e-02 -0.117000 1.65e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 11 5.03e-01 0.117000 6.60e-01
Receptor Mediated Mitophagy 11 5.03e-01 -0.117000 6.60e-01
HATs acetylate histones 83 6.66e-02 0.117000 1.55e-01
Defects in cobalamin (B12) metabolism 11 5.05e-01 0.116000 6.61e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 22 3.47e-01 -0.116000 5.19e-01
GRB2 events in ERBB2 signaling 12 4.87e-01 0.116000 6.47e-01
Membrane Trafficking 512 8.39e-06 0.116000 1.55e-04
mRNA Splicing - Major Pathway 175 8.72e-03 -0.115000 3.64e-02
Meiotic recombination 27 3.01e-01 0.115000 4.68e-01
Processing of Capped Intron-Containing Pre-mRNA 231 2.69e-03 -0.115000 1.49e-02
Hyaluronan metabolism 13 4.74e-01 -0.115000 6.36e-01
Norepinephrine Neurotransmitter Release Cycle 10 5.31e-01 0.114000 6.87e-01
Miscellaneous transport and binding events 19 3.89e-01 0.114000 5.66e-01
HS-GAG biosynthesis 17 4.18e-01 0.113000 5.88e-01
Signaling by NOTCH4 80 8.13e-02 -0.113000 1.81e-01
GPCR downstream signalling 308 7.77e-04 0.112000 5.95e-03
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 36 2.46e-01 -0.112000 4.04e-01
Recognition of DNA damage by PCNA-containing replication complex 28 3.11e-01 -0.111000 4.78e-01
G-protein mediated events 44 2.04e-01 0.111000 3.53e-01
Retinoid metabolism and transport 24 3.50e-01 0.110000 5.24e-01
MHC class II antigen presentation 82 8.54e-02 0.110000 1.87e-01
Regulation of necroptotic cell death 13 4.93e-01 0.110000 6.51e-01
RNA Polymerase III Chain Elongation 17 4.34e-01 -0.110000 6.00e-01
E3 ubiquitin ligases ubiquitinate target proteins 47 1.93e-01 0.110000 3.39e-01
Metabolism of fat-soluble vitamins 27 3.25e-01 0.110000 4.95e-01
Association of TriC/CCT with target proteins during biosynthesis 36 2.56e-01 0.110000 4.13e-01
Mitotic G1-G1/S phases 125 3.49e-02 -0.109000 9.84e-02
Clathrin-mediated endocytosis 116 4.31e-02 0.109000 1.16e-01
Interferon Signaling 154 2.01e-02 0.109000 6.53e-02
Protein-protein interactions at synapses 49 1.89e-01 0.109000 3.34e-01
Metabolism of steroid hormones 18 4.25e-01 -0.109000 5.92e-01
CLEC7A (Dectin-1) signaling 90 7.53e-02 -0.109000 1.71e-01
Defects in vitamin and cofactor metabolism 19 4.13e-01 0.108000 5.84e-01
Protein ubiquitination 67 1.26e-01 0.108000 2.48e-01
Cellular response to heat stress 93 7.15e-02 0.108000 1.64e-01
Amino acids regulate mTORC1 47 2.00e-01 -0.108000 3.46e-01
Signaling by ERBB4 43 2.22e-01 0.108000 3.72e-01
Post NMDA receptor activation events 46 2.07e-01 0.108000 3.56e-01
Thrombin signalling through proteinase activated receptors (PARs) 19 4.21e-01 0.107000 5.89e-01
Antigen processing-Cross presentation 84 9.15e-02 -0.107000 1.98e-01
Lewis blood group biosynthesis 10 5.60e-01 0.107000 7.06e-01
Deubiquitination 225 6.07e-03 0.106000 2.77e-02
Mitophagy 27 3.40e-01 -0.106000 5.12e-01
Trafficking of GluR2-containing AMPA receptors 12 5.26e-01 -0.106000 6.82e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 27 3.44e-01 -0.105000 5.17e-01
Regulation of insulin secretion 50 1.99e-01 0.105000 3.46e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 22 3.95e-01 -0.105000 5.74e-01
Trafficking of AMPA receptors 22 3.95e-01 -0.105000 5.74e-01
HIV Infection 205 1.02e-02 -0.104000 4.08e-02
Activation of SMO 13 5.15e-01 0.104000 6.73e-01
Rab regulation of trafficking 111 5.87e-02 0.104000 1.45e-01
Cargo recognition for clathrin-mediated endocytosis 80 1.09e-01 0.104000 2.26e-01
Activation of RAC1 10 5.70e-01 0.104000 7.13e-01
G1/S-Specific Transcription 19 4.35e-01 0.103000 6.02e-01
ER Quality Control Compartment (ERQC) 21 4.14e-01 0.103000 5.84e-01
RNA Polymerase III Transcription Termination 22 4.07e-01 -0.102000 5.84e-01
Interferon gamma signaling 64 1.58e-01 0.102000 2.95e-01
PIP3 activates AKT signaling 225 8.63e-03 0.102000 3.61e-02
LDL clearance 17 4.69e-01 0.101000 6.32e-01
RAF activation 30 3.37e-01 0.101000 5.08e-01
PLC beta mediated events 43 2.52e-01 0.101000 4.10e-01
Methylation 11 5.62e-01 0.101000 7.08e-01
Metabolism of steroids 109 6.99e-02 0.101000 1.62e-01
Formation of the cornified envelope 12 5.47e-01 0.100000 6.95e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 15 5.04e-01 -0.099800 6.60e-01
Adaptive Immune System 550 7.09e-05 0.099700 9.02e-04
Cholesterol biosynthesis 23 4.09e-01 0.099600 5.84e-01
Signaling by GPCR 335 1.90e-03 0.099100 1.17e-02
Post-translational protein phosphorylation 67 1.61e-01 0.099000 3.00e-01
Receptor-type tyrosine-protein phosphatases 11 5.70e-01 0.098900 7.13e-01
TNF signaling 40 2.82e-01 0.098300 4.46e-01
ADP signalling through P2Y purinoceptor 12 12 5.56e-01 0.098100 7.03e-01
tRNA processing in the nucleus 53 2.17e-01 -0.098000 3.68e-01
Class I peroxisomal membrane protein import 19 4.60e-01 -0.097900 6.22e-01
Intracellular signaling by second messengers 259 6.92e-03 0.097700 3.12e-02
FGFR2 alternative splicing 24 4.08e-01 -0.097700 5.84e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 15 5.15e-01 -0.097200 6.73e-01
Sulfur amino acid metabolism 23 4.20e-01 -0.097100 5.89e-01
Host Interactions with Influenza Factors 40 2.90e-01 0.096800 4.56e-01
Signaling by FGFR2 IIIa TM 17 4.91e-01 -0.096600 6.50e-01
RNA Polymerase I Promoter Opening 13 5.47e-01 0.096400 6.95e-01
Caspase activation via extrinsic apoptotic signalling pathway 21 4.46e-01 0.096100 6.08e-01
E2F mediated regulation of DNA replication 18 4.83e-01 0.095600 6.45e-01
Class I MHC mediated antigen processing & presentation 332 2.99e-03 0.095200 1.58e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation 29 3.77e-01 -0.094900 5.54e-01
Leading Strand Synthesis 14 5.40e-01 -0.094700 6.92e-01
Polymerase switching 14 5.40e-01 -0.094700 6.92e-01
Polymerase switching on the C-strand of the telomere 14 5.40e-01 -0.094700 6.92e-01
Base-Excision Repair, AP Site Formation 25 4.13e-01 -0.094600 5.84e-01
Chaperone Mediated Autophagy 18 4.90e-01 0.094000 6.50e-01
Activation of NMDA receptors and postsynaptic events 54 2.35e-01 0.093500 3.90e-01
Mitotic Telophase/Cytokinesis 10 6.09e-01 0.093300 7.46e-01
EPHB-mediated forward signaling 31 3.69e-01 0.093300 5.45e-01
Signaling by NOTCH 173 3.52e-02 0.093000 9.88e-02
Scavenging by Class A Receptors 14 5.48e-01 0.092800 6.95e-01
G-protein activation 15 5.35e-01 0.092600 6.90e-01
Acyl chain remodelling of PC 13 5.67e-01 -0.091800 7.12e-01
Thromboxane signalling through TP receptor 13 5.67e-01 0.091700 7.12e-01
Golgi-to-ER retrograde transport 95 1.25e-01 0.091200 2.48e-01
CASP8 activity is inhibited 10 6.19e-01 -0.090900 7.50e-01
Dimerization of procaspase-8 10 6.19e-01 -0.090900 7.50e-01
Regulation by c-FLIP 10 6.19e-01 -0.090900 7.50e-01
Striated Muscle Contraction 31 3.82e-01 -0.090800 5.60e-01
HIV elongation arrest and recovery 28 4.06e-01 -0.090700 5.84e-01
Pausing and recovery of HIV elongation 28 4.06e-01 -0.090700 5.84e-01
Transport of Mature Transcript to Cytoplasm 77 1.72e-01 -0.090000 3.14e-01
Glucagon signaling in metabolic regulation 23 4.55e-01 0.090000 6.18e-01
Potassium Channels 35 3.58e-01 0.089800 5.33e-01
Polo-like kinase mediated events 10 6.23e-01 0.089700 7.54e-01
Reproduction 58 2.38e-01 0.089700 3.95e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 5.78e-01 0.089200 7.18e-01
Retrograde neurotrophin signalling 11 6.09e-01 0.089100 7.46e-01
Glycosphingolipid metabolism 35 3.67e-01 -0.088200 5.44e-01
Deadenylation-dependent mRNA decay 56 2.54e-01 0.088100 4.12e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 68 2.10e-01 -0.088000 3.59e-01
G2/M Transition 165 5.37e-02 -0.087200 1.36e-01
Synthesis of PE 11 6.17e-01 -0.087200 7.50e-01
Opioid Signalling 69 2.12e-01 0.087000 3.61e-01
Transferrin endocytosis and recycling 21 4.91e-01 -0.086900 6.50e-01
PIWI-interacting RNA (piRNA) biogenesis 18 5.26e-01 -0.086300 6.82e-01
NS1 Mediated Effects on Host Pathways 38 3.60e-01 0.085800 5.36e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 73 2.07e-01 0.085600 3.56e-01
Metabolism 1564 3.35e-08 -0.085200 1.01e-06
G2/M Checkpoints 117 1.12e-01 -0.085200 2.30e-01
Nuclear Pore Complex (NPC) Disassembly 32 4.06e-01 0.085000 5.84e-01
Downstream TCR signaling 83 1.83e-01 -0.084600 3.26e-01
Insulin receptor recycling 18 5.35e-01 -0.084500 6.90e-01
HS-GAG degradation 13 5.99e-01 -0.084300 7.38e-01
Plasma lipoprotein assembly 12 6.14e-01 -0.084100 7.50e-01
Triglyceride catabolism 16 5.62e-01 -0.083800 7.08e-01
Negative regulation of MET activity 18 5.38e-01 0.083800 6.92e-01
Regulation of HSF1-mediated heat shock response 75 2.11e-01 0.083500 3.61e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 85 1.84e-01 -0.083400 3.27e-01
Mitotic G2-G2/M phases 166 6.53e-02 -0.083100 1.53e-01
Senescence-Associated Secretory Phenotype (SASP) 53 2.99e-01 0.082600 4.66e-01
MicroRNA (miRNA) biogenesis 24 4.85e-01 -0.082400 6.45e-01
p75NTR signals via NF-kB 14 5.95e-01 0.082100 7.35e-01
Stimuli-sensing channels 53 3.02e-01 -0.082000 4.68e-01
FLT3 Signaling 195 4.89e-02 0.082000 1.28e-01
Regulation of FZD by ubiquitination 15 5.83e-01 0.081900 7.22e-01
Synthesis of substrates in N-glycan biosythesis 54 3.00e-01 -0.081700 4.66e-01
Biological oxidations 113 1.35e-01 -0.081500 2.61e-01
Mitotic Spindle Checkpoint 82 2.03e-01 0.081500 3.51e-01
Neurotransmitter release cycle 29 4.52e-01 0.080800 6.14e-01
NRIF signals cell death from the nucleus 14 6.02e-01 -0.080400 7.41e-01
Signaling by Retinoic Acid 33 4.25e-01 0.080300 5.92e-01
Regulation of Complement cascade 17 5.70e-01 0.079600 7.13e-01
G alpha (i) signalling events 168 7.70e-02 0.079200 1.73e-01
Loss of function of MECP2 in Rett syndrome 11 6.50e-01 0.079100 7.76e-01
Pervasive developmental disorders 11 6.50e-01 0.079100 7.76e-01
Regulation of TP53 Activity through Phosphorylation 83 2.17e-01 0.078400 3.68e-01
SUMOylation of ubiquitinylation proteins 37 4.10e-01 0.078300 5.84e-01
RNA Polymerase I Transcription Termination 29 4.69e-01 -0.077700 6.32e-01
Diseases of metabolism 68 2.69e-01 -0.077600 4.29e-01
Generic Transcription Pathway 983 5.02e-05 0.077300 6.88e-04
Ub-specific processing proteases 156 9.69e-02 0.077200 2.07e-01
COPI-mediated anterograde transport 79 2.36e-01 0.077100 3.93e-01
Post-translational protein modification 1094 2.21e-05 0.076900 3.66e-04
HDACs deacetylate histones 37 4.23e-01 0.076200 5.91e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 159 9.81e-02 0.076200 2.08e-01
Regulated proteolysis of p75NTR 10 6.77e-01 0.076100 7.94e-01
Processing of Intronless Pre-mRNAs 19 5.67e-01 -0.075800 7.12e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 40 4.08e-01 0.075700 5.84e-01
Activation of AMPK downstream of NMDARs 10 6.80e-01 0.075400 7.96e-01
Signaling by Hedgehog 121 1.53e-01 -0.075200 2.89e-01
RNA Polymerase III Abortive And Retractive Initiation 40 4.11e-01 -0.075200 5.84e-01
RNA Polymerase III Transcription 40 4.11e-01 -0.075200 5.84e-01
MAPK1/MAPK3 signaling 187 7.74e-02 0.075000 1.73e-01
RNA Polymerase III Transcription Initiation 35 4.43e-01 -0.075000 6.07e-01
Metabolism of folate and pterines 14 6.27e-01 0.075000 7.57e-01
mTORC1-mediated signalling 23 5.34e-01 -0.074900 6.90e-01
Negative regulation of MAPK pathway 39 4.19e-01 0.074800 5.88e-01
G beta:gamma signalling through PLC beta 12 6.54e-01 -0.074800 7.79e-01
Presynaptic function of Kainate receptors 12 6.54e-01 -0.074800 7.79e-01
Transport of Ribonucleoproteins into the Host Nucleus 30 4.79e-01 0.074700 6.42e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 6.55e-01 0.074500 7.79e-01
Antigen processing: Ubiquitination & Proteasome degradation 283 3.32e-02 0.073800 9.51e-02
Chondroitin sulfate/dermatan sulfate metabolism 37 4.40e-01 0.073400 6.04e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 26 5.21e-01 -0.072700 6.80e-01
G beta:gamma signalling through CDC42 12 6.65e-01 -0.072100 7.85e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 12 6.66e-01 0.072100 7.85e-01
Fatty acid metabolism 115 1.87e-01 -0.071400 3.31e-01
Gene expression (Transcription) 1226 3.58e-05 0.071200 5.39e-04
RNA Polymerase II Transcription 1101 1.04e-04 0.070200 1.18e-03
DAG and IP3 signaling 35 4.72e-01 0.070200 6.35e-01
Retrograde transport at the Trans-Golgi-Network 48 4.04e-01 0.069600 5.84e-01
WNT5A-dependent internalization of FZD4 13 6.65e-01 0.069400 7.85e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 17 6.22e-01 -0.069100 7.53e-01
Peptide hormone metabolism 46 4.19e-01 0.069000 5.88e-01
SUMOylation of RNA binding proteins 45 4.25e-01 0.068800 5.92e-01
Cytochrome P450 - arranged by substrate type 26 5.44e-01 0.068800 6.93e-01
Export of Viral Ribonucleoproteins from Nucleus 31 5.10e-01 0.068400 6.67e-01
Calnexin/calreticulin cycle 26 5.48e-01 0.068200 6.95e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 18 6.17e-01 0.068100 7.50e-01
CaM pathway 29 5.26e-01 0.068100 6.82e-01
Calmodulin induced events 29 5.26e-01 0.068100 6.82e-01
SLC-mediated transmembrane transport 139 1.67e-01 -0.067900 3.07e-01
RAB geranylgeranylation 48 4.16e-01 0.067900 5.87e-01
Golgi Cisternae Pericentriolar Stack Reorganization 12 6.84e-01 0.067800 7.99e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 17 6.29e-01 0.067700 7.57e-01
N-Glycan antennae elongation 12 6.85e-01 0.067700 7.99e-01
Cytosolic sulfonation of small molecules 13 6.73e-01 -0.067600 7.92e-01
Innate Immune System 693 2.77e-03 0.067200 1.50e-02
CS/DS degradation 10 7.13e-01 0.067200 8.22e-01
Cleavage of the damaged pyrimidine 23 5.79e-01 -0.066900 7.18e-01
Depyrimidination 23 5.79e-01 -0.066900 7.18e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 23 5.79e-01 -0.066900 7.18e-01
Transcriptional Regulation by TP53 325 3.93e-02 0.066700 1.09e-01
WNT ligand biogenesis and trafficking 13 6.78e-01 -0.066500 7.94e-01
Platelet homeostasis 61 3.73e-01 0.066000 5.51e-01
Purine catabolism 15 6.59e-01 -0.065800 7.82e-01
Glycogen metabolism 25 5.73e-01 0.065200 7.15e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 6.84e-01 -0.065100 7.99e-01
GPCR ligand binding 117 2.25e-01 0.065100 3.76e-01
Glucose metabolism 74 3.36e-01 -0.064800 5.08e-01
TICAM1-dependent activation of IRF3/IRF7 11 7.11e-01 0.064500 8.22e-01
TNFR1-induced proapoptotic signaling 12 6.99e-01 0.064500 8.11e-01
Negative epigenetic regulation of rRNA expression 55 4.09e-01 0.064400 5.84e-01
Regulation of TP53 Activity through Methylation 17 6.46e-01 -0.064300 7.73e-01
Caspase activation via Death Receptors in the presence of ligand 13 6.88e-01 0.064300 8.01e-01
Interleukin-1 signaling 91 2.98e-01 -0.063200 4.65e-01
Ca-dependent events 30 5.51e-01 0.062900 6.98e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 59 4.08e-01 0.062400 5.84e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 6.77e-01 0.062200 7.94e-01
Microautophagy 28 5.70e-01 -0.062100 7.13e-01
RNA polymerase II transcribes snRNA genes 72 3.64e-01 0.061900 5.41e-01
Neuronal System 203 1.30e-01 0.061800 2.55e-01
Frs2-mediated activation 10 7.36e-01 0.061700 8.39e-01
Ion homeostasis 43 4.84e-01 0.061700 6.45e-01
Glycogen synthesis 14 6.90e-01 0.061600 8.01e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 7.12e-01 0.061500 8.22e-01
alpha-linolenic acid (ALA) metabolism 12 7.12e-01 0.061500 8.22e-01
Deposition of new CENPA-containing nucleosomes at the centromere 28 5.76e-01 -0.061000 7.18e-01
Nucleosome assembly 28 5.76e-01 -0.061000 7.18e-01
DNA Damage Bypass 44 4.84e-01 -0.061000 6.45e-01
Signaling by WNT 224 1.17e-01 0.060900 2.39e-01
RAF/MAP kinase cascade 182 1.63e-01 0.060100 3.01e-01
Cytosolic sensors of pathogen-associated DNA 56 4.37e-01 0.060000 6.03e-01
Cellular responses to external stimuli 374 4.87e-02 0.059600 1.28e-01
NCAM1 interactions 22 6.33e-01 0.058900 7.61e-01
Zinc transporters 13 7.14e-01 0.058700 8.23e-01
TP53 Regulates Transcription of Cell Death Genes 38 5.32e-01 0.058700 6.88e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 6.77e-01 0.058400 7.94e-01
Long-term potentiation 13 7.18e-01 -0.057800 8.24e-01
Separation of Sister Chromatids 136 2.46e-01 -0.057700 4.04e-01
Organelle biogenesis and maintenance 242 1.30e-01 0.056700 2.54e-01
Loss of Nlp from mitotic centrosomes 65 4.40e-01 0.055400 6.04e-01
Loss of proteins required for interphase microtubule organization from the centrosome 65 4.40e-01 0.055400 6.04e-01
Programmed Cell Death 152 2.43e-01 0.055000 4.00e-01
Transcriptional regulation by small RNAs 54 4.93e-01 0.054000 6.51e-01
Beta-catenin independent WNT signaling 122 3.05e-01 -0.053900 4.71e-01
Cardiac conduction 79 4.09e-01 0.053800 5.84e-01
HIV Transcription Initiation 43 5.43e-01 -0.053700 6.92e-01
RNA Polymerase II HIV Promoter Escape 43 5.43e-01 -0.053700 6.92e-01
RNA Polymerase II Promoter Escape 43 5.43e-01 -0.053700 6.92e-01
RNA Polymerase II Transcription Initiation 43 5.43e-01 -0.053700 6.92e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 43 5.43e-01 -0.053700 6.92e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 43 5.43e-01 -0.053700 6.92e-01
Cellular responses to stress 368 7.84e-02 0.053600 1.75e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 6.43e-01 0.053600 7.70e-01
TP53 Regulates Transcription of DNA Repair Genes 54 5.02e-01 -0.052800 6.60e-01
HDR through Single Strand Annealing (SSA) 33 6.06e-01 0.052000 7.44e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 7.46e-01 -0.051900 8.47e-01
IRF3-mediated induction of type I IFN 10 7.76e-01 -0.051900 8.68e-01
Unfolded Protein Response (UPR) 85 4.10e-01 0.051700 5.84e-01
NoRC negatively regulates rRNA expression 52 5.22e-01 0.051400 6.80e-01
Transcriptional regulation by RUNX3 90 4.02e-01 0.051200 5.82e-01
Effects of PIP2 hydrolysis 20 6.94e-01 -0.050800 8.06e-01
SUMOylation of DNA damage response and repair proteins 71 4.66e-01 0.050100 6.29e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 11 7.74e-01 0.050100 8.68e-01
Regulation of PLK1 Activity at G2/M Transition 80 4.43e-01 0.049700 6.07e-01
ATF6 (ATF6-alpha) activates chaperones 11 7.77e-01 0.049400 8.68e-01
TCF dependent signaling in response to WNT 155 2.95e-01 0.048800 4.63e-01
Chaperonin-mediated protein folding 73 4.73e-01 0.048700 6.35e-01
C-type lectin receptors (CLRs) 110 3.79e-01 -0.048600 5.56e-01
Interleukin-12 family signaling 40 5.97e-01 0.048300 7.37e-01
Post-chaperonin tubulin folding pathway 16 7.39e-01 -0.048200 8.42e-01
Prolactin receptor signaling 10 7.92e-01 0.048100 8.76e-01
STING mediated induction of host immune responses 12 7.75e-01 -0.047700 8.68e-01
tRNA processing 128 3.54e-01 -0.047600 5.27e-01
Smooth Muscle Contraction 35 6.27e-01 0.047500 7.57e-01
Synthesis of IP3 and IP4 in the cytosol 22 7.01e-01 0.047300 8.12e-01
NF-kB is activated and signals survival 11 7.86e-01 -0.047200 8.73e-01
Apoptosis 150 3.20e-01 0.047100 4.90e-01
Cytochrome c-mediated apoptotic response 13 7.69e-01 0.047000 8.64e-01
Collagen chain trimerization 29 6.64e-01 -0.046700 7.85e-01
O-linked glycosylation 62 5.26e-01 0.046600 6.82e-01
Viral Messenger RNA Synthesis 41 6.06e-01 -0.046600 7.44e-01
Diseases associated with O-glycosylation of proteins 41 6.07e-01 -0.046500 7.44e-01
TCR signaling 97 4.30e-01 -0.046400 5.97e-01
Glutamate Neurotransmitter Release Cycle 16 7.51e-01 0.045900 8.50e-01
DNA Repair 260 2.05e-01 -0.045800 3.54e-01
MAPK6/MAPK4 signaling 78 4.86e-01 -0.045600 6.47e-01
Asparagine N-linked glycosylation 254 2.13e-01 0.045500 3.63e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 7.88e-01 -0.044800 8.73e-01
Processing of DNA double-strand break ends 61 5.46e-01 0.044700 6.95e-01
Neurotransmitter receptors and postsynaptic signal transmission 106 4.29e-01 0.044500 5.96e-01
Interleukin-12 signaling 34 6.62e-01 -0.043300 7.84e-01
TBC/RABGAPs 42 6.29e-01 0.043100 7.57e-01
Transport of small molecules 471 1.12e-01 -0.043000 2.30e-01
ROS and RNS production in phagocytes 24 7.17e-01 0.042700 8.24e-01
Inositol phosphate metabolism 41 6.39e-01 0.042400 7.68e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 65 5.57e-01 -0.042100 7.04e-01
Glyoxylate metabolism and glycine degradation 24 7.21e-01 -0.042100 8.27e-01
Dectin-2 family 10 8.22e-01 -0.041100 8.97e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 26 7.17e-01 0.041000 8.24e-01
Metalloprotease DUBs 19 7.57e-01 -0.041000 8.54e-01
Citric acid cycle (TCA cycle) 22 7.40e-01 0.040900 8.42e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 8.16e-01 -0.040400 8.94e-01
Developmental Biology 642 8.39e-02 0.040300 1.85e-01
Formation of RNA Pol II elongation complex 51 6.19e-01 -0.040300 7.50e-01
RNA Polymerase II Transcription Elongation 51 6.19e-01 -0.040300 7.50e-01
Triglyceride metabolism 24 7.35e-01 -0.040000 8.39e-01
Phospholipid metabolism 160 3.86e-01 0.039800 5.62e-01
RA biosynthesis pathway 14 7.98e-01 -0.039600 8.80e-01
Transmission across Chemical Synapses 144 4.14e-01 0.039500 5.84e-01
Phase I - Functionalization of compounds 56 6.11e-01 0.039300 7.47e-01
Sialic acid metabolism 27 7.25e-01 -0.039100 8.30e-01
Assembly and cell surface presentation of NMDA receptors 16 7.87e-01 -0.039100 8.73e-01
Axon guidance 422 1.76e-01 -0.038600 3.20e-01
CLEC7A (Dectin-1) induces NFAT activation 11 8.25e-01 0.038500 8.98e-01
Nuclear signaling by ERBB4 24 7.47e-01 0.038000 8.47e-01
Metabolism of non-coding RNA 51 6.42e-01 -0.037600 7.70e-01
snRNP Assembly 51 6.42e-01 -0.037600 7.70e-01
Hyaluronan uptake and degradation 10 8.37e-01 -0.037600 9.01e-01
Mitotic Anaphase 146 4.36e-01 -0.037400 6.02e-01
Downregulation of ERBB2 signaling 23 7.56e-01 -0.037400 8.54e-01
Platelet calcium homeostasis 19 7.78e-01 0.037300 8.69e-01
NEP/NS2 Interacts with the Cellular Export Machinery 30 7.24e-01 0.037300 8.29e-01
HIV Life Cycle 135 4.56e-01 -0.037200 6.18e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 22 7.64e-01 0.036900 8.60e-01
Homologous DNA Pairing and Strand Exchange 35 7.11e-01 0.036200 8.22e-01
Gene Silencing by RNA 75 5.88e-01 0.036200 7.28e-01
Biotin transport and metabolism 11 8.36e-01 0.036000 9.01e-01
HDR through Homologous Recombination (HRR) 55 6.45e-01 -0.035900 7.72e-01
Termination of O-glycan biosynthesis 13 8.24e-01 0.035700 8.98e-01
Adrenaline,noradrenaline inhibits insulin secretion 18 7.94e-01 0.035500 8.77e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 27 7.54e-01 -0.034900 8.52e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 28 7.52e-01 0.034600 8.50e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 28 7.52e-01 0.034600 8.50e-01
AURKA Activation by TPX2 68 6.26e-01 0.034200 7.57e-01
Mitotic Metaphase and Anaphase 147 4.80e-01 -0.033800 6.42e-01
Muscle contraction 139 4.93e-01 0.033700 6.51e-01
Presynaptic phase of homologous DNA pairing and strand exchange 33 7.41e-01 0.033300 8.43e-01
The role of Nef in HIV-1 replication and disease pathogenesis 20 7.99e-01 -0.032900 8.81e-01
Synthesis of PC 23 7.85e-01 -0.032900 8.73e-01
Resolution of D-Loop Structures 23 7.88e-01 -0.032500 8.73e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 23 7.88e-01 -0.032500 8.73e-01
Mitotic Prometaphase 148 5.02e-01 0.032000 6.60e-01
DNA Double-Strand Break Repair 118 5.51e-01 0.031800 6.98e-01
Prefoldin mediated transfer of substrate to CCT/TriC 24 7.88e-01 0.031700 8.73e-01
TP53 Regulates Metabolic Genes 83 6.19e-01 0.031600 7.50e-01
RNA Polymerase I Promoter Clearance 57 6.83e-01 0.031300 7.99e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 8.58e-01 0.031200 9.17e-01
Sphingolipid metabolism 68 6.62e-01 0.030600 7.84e-01
RMTs methylate histone arginines 34 7.59e-01 0.030400 8.56e-01
SUMOylation of SUMOylation proteins 33 7.64e-01 0.030200 8.60e-01
Metabolism of lipids 543 2.32e-01 0.030200 3.86e-01
Vitamin B5 (pantothenate) metabolism 14 8.46e-01 0.029900 9.10e-01
VLDLR internalisation and degradation 11 8.64e-01 0.029900 9.21e-01
Synthesis of PA 22 8.15e-01 0.028800 8.94e-01
G alpha (s) signalling events 68 6.86e-01 -0.028400 7.99e-01
Adherens junctions interactions 14 8.56e-01 0.027900 9.17e-01
Nuclear import of Rev protein 32 7.87e-01 0.027600 8.73e-01
Plasma lipoprotein clearance 26 8.09e-01 0.027500 8.90e-01
RNA Polymerase II Pre-transcription Events 73 6.85e-01 0.027400 7.99e-01
Glycerophospholipid biosynthesis 89 6.57e-01 -0.027300 7.80e-01
Late Phase of HIV Life Cycle 123 6.03e-01 -0.027200 7.41e-01
FGFR2 mutant receptor activation 20 8.34e-01 -0.027100 9.01e-01
Transport of Mature mRNA Derived from an Intronless Transcript 40 7.76e-01 -0.026000 8.68e-01
IRAK2 mediated activation of TAK1 complex 10 8.89e-01 0.025600 9.40e-01
Diseases of glycosylation 103 6.55e-01 -0.025500 7.79e-01
Neutrophil degranulation 339 4.25e-01 0.025300 5.92e-01
RNA Polymerase I Transcription 59 7.42e-01 0.024800 8.43e-01
Assembly of collagen fibrils and other multimeric structures 42 7.83e-01 -0.024600 8.73e-01
Fc epsilon receptor (FCERI) signaling 115 6.60e-01 -0.023800 7.82e-01
Negative regulators of DDX58/IFIH1 signaling 33 8.16e-01 -0.023500 8.94e-01
Lysosome Vesicle Biogenesis 28 8.30e-01 0.023400 9.01e-01
Interactions of Vpr with host cellular proteins 35 8.12e-01 -0.023200 8.93e-01
PERK regulates gene expression 30 8.30e-01 0.022600 9.01e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 8.97e-01 -0.022400 9.44e-01
Anchoring of the basal body to the plasma membrane 91 7.17e-01 0.022000 8.24e-01
Glycolysis 60 7.71e-01 -0.021800 8.65e-01
Transport of bile salts and organic acids, metal ions and amine compounds 37 8.22e-01 0.021400 8.97e-01
Metabolism of carbohydrates 216 5.91e-01 0.021300 7.30e-01
RNA Polymerase I Promoter Escape 38 8.22e-01 0.021100 8.97e-01
Metabolism of vitamins and cofactors 137 6.72e-01 0.021000 7.91e-01
RNA Polymerase I Transcription Initiation 44 8.10e-01 0.020900 8.91e-01
Activation of G protein gated Potassium channels 11 9.07e-01 0.020300 9.47e-01
G protein gated Potassium channels 11 9.07e-01 0.020300 9.47e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 11 9.07e-01 0.020300 9.47e-01
p75NTR recruits signalling complexes 11 9.09e-01 0.019900 9.48e-01
Regulation of TNFR1 signaling 31 8.48e-01 0.019900 9.11e-01
Transcriptional regulation by RUNX2 105 7.27e-01 0.019700 8.31e-01
G beta:gamma signalling through PI3Kgamma 14 8.99e-01 0.019500 9.45e-01
Collagen biosynthesis and modifying enzymes 45 8.22e-01 -0.019400 8.97e-01
Cleavage of the damaged purine 18 8.88e-01 0.019200 9.40e-01
Depurination 18 8.88e-01 0.019200 9.40e-01
Recognition and association of DNA glycosylase with site containing an affected purine 18 8.88e-01 0.019200 9.40e-01
mTOR signalling 40 8.34e-01 0.019100 9.01e-01
Carboxyterminal post-translational modifications of tubulin 24 8.72e-01 -0.019000 9.27e-01
ERKs are inactivated 13 9.07e-01 0.018700 9.47e-01
IRE1alpha activates chaperones 47 8.25e-01 0.018600 8.98e-01
Intraflagellar transport 36 8.50e-01 0.018200 9.12e-01
Visual phototransduction 49 8.29e-01 0.017900 9.01e-01
Cyclin A/B1/B2 associated events during G2/M transition 18 8.97e-01 0.017700 9.44e-01
Inwardly rectifying K+ channels 16 9.03e-01 0.017600 9.47e-01
Cargo trafficking to the periciliary membrane 43 8.43e-01 0.017500 9.07e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 8.58e-01 0.017400 9.17e-01
Basigin interactions 17 9.02e-01 -0.017300 9.46e-01
COPI-dependent Golgi-to-ER retrograde traffic 63 8.16e-01 -0.016900 8.94e-01
Rev-mediated nuclear export of HIV RNA 33 8.67e-01 -0.016800 9.23e-01
Transport of the SLBP Dependant Mature mRNA 34 8.67e-01 0.016700 9.23e-01
Mismatch Repair 14 9.16e-01 -0.016200 9.54e-01
Intrinsic Pathway of Fibrin Clot Formation 11 9.26e-01 -0.016100 9.59e-01
SUMOylation of DNA replication proteins 40 8.63e-01 0.015800 9.21e-01
Advanced glycosylation endproduct receptor signaling 10 9.32e-01 0.015600 9.61e-01
Cristae formation 13 9.23e-01 0.015400 9.57e-01
Metabolism of proteins 1580 3.20e-01 -0.015300 4.90e-01
Cell Cycle 473 5.71e-01 0.015300 7.13e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 51 8.51e-01 0.015200 9.13e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 25 8.97e-01 0.015000 9.44e-01
Autophagy 107 7.91e-01 0.014800 8.76e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 21 9.07e-01 0.014800 9.47e-01
PI3K events in ERBB2 signaling 12 9.31e-01 -0.014400 9.61e-01
Lysine catabolism 10 9.38e-01 -0.014200 9.65e-01
XBP1(S) activates chaperone genes 45 8.69e-01 0.014200 9.25e-01
SUMOylation of immune response proteins 10 9.40e-01 0.013700 9.66e-01
Protein folding 79 8.33e-01 0.013700 9.01e-01
Centrosome maturation 77 8.35e-01 -0.013700 9.01e-01
Recruitment of mitotic centrosome proteins and complexes 77 8.35e-01 -0.013700 9.01e-01
Apoptotic factor-mediated response 16 9.28e-01 -0.013000 9.59e-01
M Phase 280 7.15e-01 -0.012700 8.23e-01
The phototransduction cascade 17 9.28e-01 -0.012600 9.59e-01
O-glycosylation of TSR domain-containing proteins 26 9.13e-01 -0.012300 9.52e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 16 9.32e-01 -0.012300 9.61e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 41 8.92e-01 -0.012200 9.43e-01
Bile acid and bile salt metabolism 24 9.21e-01 0.011700 9.56e-01
Synthesis of bile acids and bile salts 24 9.21e-01 0.011700 9.56e-01
Iron uptake and transport 44 8.99e-01 0.011100 9.45e-01
Signal transduction by L1 18 9.36e-01 -0.011000 9.63e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 9.41e-01 -0.010300 9.66e-01
Keratinization 14 9.47e-01 0.010300 9.69e-01
PTEN Regulation 137 8.36e-01 0.010200 9.01e-01
Interleukin-1 family signaling 111 8.59e-01 -0.009810 9.17e-01
Vpr-mediated nuclear import of PICs 32 9.26e-01 -0.009510 9.59e-01
Macroautophagy 88 8.79e-01 -0.009420 9.32e-01
Homology Directed Repair 92 8.76e-01 -0.009410 9.30e-01
InlB-mediated entry of Listeria monocytogenes into host cell 13 9.54e-01 -0.009320 9.73e-01
Acyl chain remodelling of PE 12 9.56e-01 -0.009300 9.74e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 9.52e-01 -0.008980 9.73e-01
G-protein beta:gamma signalling 20 9.45e-01 -0.008950 9.68e-01
Inactivation, recovery and regulation of the phototransduction cascade 16 9.53e-01 -0.008520 9.73e-01
Formation of apoptosome 11 9.61e-01 0.008510 9.77e-01
Regulation of the apoptosome activity 11 9.61e-01 0.008510 9.77e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 29 9.44e-01 0.007520 9.68e-01
Recruitment of NuMA to mitotic centrosomes 76 9.16e-01 -0.007010 9.54e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 9.47e-01 -0.006960 9.69e-01
Complement cascade 20 9.58e-01 -0.006780 9.76e-01
IL-6-type cytokine receptor ligand interactions 12 9.69e-01 -0.006530 9.81e-01
SLC transporter disorders 59 9.34e-01 -0.006240 9.62e-01
Cell Cycle, Mitotic 393 8.33e-01 -0.006220 9.01e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 87 9.23e-01 0.006010 9.57e-01
Cilium Assembly 168 8.94e-01 0.005950 9.43e-01
Metabolic disorders of biological oxidation enzymes 19 9.68e-01 0.005390 9.81e-01
Neddylation 214 8.93e-01 -0.005350 9.43e-01
Disease 827 8.03e-01 -0.005170 8.84e-01
Heparan sulfate/heparin (HS-GAG) metabolism 32 9.62e-01 -0.004880 9.77e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 9.73e-01 0.004780 9.82e-01
Metabolism of cofactors 17 9.73e-01 0.004730 9.82e-01
Nucleobase catabolism 29 9.65e-01 -0.004640 9.80e-01
Pentose phosphate pathway 11 9.81e-01 0.004200 9.87e-01
Interactions of Rev with host cellular proteins 35 9.71e-01 0.003550 9.81e-01
Ion channel transport 107 9.59e-01 -0.002900 9.76e-01
Transcription of the HIV genome 62 9.69e-01 -0.002840 9.81e-01
Collagen formation 62 9.70e-01 -0.002750 9.81e-01
Nicotinamide salvaging 13 9.86e-01 0.002730 9.91e-01
Energy dependent regulation of mTOR by LKB1-AMPK 29 9.86e-01 -0.001890 9.91e-01
Metabolism of water-soluble vitamins and cofactors 94 9.79e-01 -0.001550 9.87e-01
Synthesis of very long-chain fatty acyl-CoAs 14 9.94e-01 -0.001130 9.97e-01
Cell Cycle Checkpoints 208 9.81e-01 -0.000981 9.87e-01
Transport of the SLBP independent Mature mRNA 33 9.94e-01 0.000802 9.97e-01
Josephin domain DUBs 11 9.97e-01 0.000562 9.99e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 28 9.98e-01 -0.000267 9.99e-01
Pyruvate metabolism 27 9.99e-01 -0.000169 9.99e-01
Fatty acyl-CoA biosynthesis 24 9.99e-01 0.000125 9.99e-01


Detailed Gene set reports



Regulation of FOXO transcriptional activity by acetylation
set Regulation of FOXO transcriptional activity by acetylation
setSize 10
pANOVA 0.000158
s.dist 0.69
p.adjustANOVA 0.00163


Top enriched genes
Top 20 genes
GeneID Gene Rank
FOXO3 7314.5
SIRT1 7277.5
FOXO1 7276.5
EP300 6731.5
TXNIP 6725.5
CREBBP 6697.5
KAT2B 6292.5
FOXO4 6237.5
SIRT3 -359.5
TXN -2531.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FOXO3 7314.5
SIRT1 7277.5
FOXO1 7276.5
EP300 6731.5
TXNIP 6725.5
CREBBP 6697.5
KAT2B 6292.5
FOXO4 6237.5
SIRT3 -359.5
TXN -2531.5


Peptide chain elongation
set Peptide chain elongation
setSize 87
pANOVA 1.06e-26
s.dist -0.663
p.adjustANOVA 3.28e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS25 -7230.5
RPL35 -7204.5
RPL35A -7174.5
RPS13 -7171.5
RPL37 -7150.5
RPS8 -7146.5
RPS12 -7128.5
RPL26 -7115.5
RPL32 -7108.5
RPL27A -7094.5
RPL37A -7084.5
RPL36AL -7021.5
RPL34 -6992.5
RPS24 -6965.5
RPS6 -6945.5
RPS20 -6935.5
RPS18 -6907.5
RPS17 -6897.5
RPS21 -6874.5
UBA52 -6866.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS25 -7230.5
RPL35 -7204.5
RPL35A -7174.5
RPS13 -7171.5
RPL37 -7150.5
RPS8 -7146.5
RPS12 -7128.5
RPL26 -7115.5
RPL32 -7108.5
RPL27A -7094.5
RPL37A -7084.5
RPL36AL -7021.5
RPL34 -6992.5
RPS24 -6965.5
RPS6 -6945.5
RPS20 -6935.5
RPS18 -6907.5
RPS17 -6897.5
RPS21 -6874.5
UBA52 -6866.5
RPS16 -6775.5
RPL11 -6771.5
RPL28 -6747.5
RPL19 -6743.5
RPLP1 -6723.5
RPL13 -6699.5
RPL36 -6698.5
RPL12 -6686.5
RPL18 -6683.5
RPL30 -6654.5
RPS15A -6643.5
RPL14 -6622.5
RPL29 -6611.5
RPS5 -6609.5
RPS27A -6566.5
RPL6 -6518.5
RPLP0 -6505.5
RPS27L -6442.5
RPL5 -6328.5
RPL41 -6326.5
RPL27 -6274.5
RPL38 -6203.5
RPS19 -6200.5
FAU -6193.5
RPL10A -6180.5
RPS2 -6131.5
RPLP2 -6111.5
RPL31 -6066.5
RPS11 -5965.5
RPL23 -5877.5
RPS4X -5702.5
RPL13A -5655.5
RPS14 -5637.5
RPS7 -5383.5
RPS29 -5338.5
RPL15 -5180.5
RPS10 -5037.5
RPL4 -4739.5
RPL36A -4638.5
RPS3 -4564.5
RPL8 -4521.5
RPS9 -4369.5
RPL7A -4346.5
RPS15 -4298.5
RPS26 -4234.5
RPL24 -4179.5
RPS23 -4169.5
RPL39 -4091.5
RPL22 -3933.5
RPL10 -3823.5
RPS28 -3737.5
RPL18A -2379.5
RPL3L -2256.5
RPSA -1706.5
RPL23A -1308.5
RPS27 -993.5
EEF1A1 81.5
RPL26L1 319.5
RPL9 469.5
RPS4Y1 549.5
RPL22L1 1190.5
EEF2 1812.5
RPS3A 1867.5
RPL3 3111.5
RPL21 4530.5
RPL17 5016.5
RPL7 6867.5


Viral mRNA Translation
set Viral mRNA Translation
setSize 87
pANOVA 4.35e-26
s.dist -0.655
p.adjustANOVA 8.94e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS25 -7230.5
RPL35 -7204.5
RPL35A -7174.5
RPS13 -7171.5
RPL37 -7150.5
RPS8 -7146.5
RPS12 -7128.5
RPL26 -7115.5
RPL32 -7108.5
RPL27A -7094.5
RPL37A -7084.5
RPL36AL -7021.5
RPL34 -6992.5
RPS24 -6965.5
RPS6 -6945.5
RPS20 -6935.5
RPS18 -6907.5
RPS17 -6897.5
RPS21 -6874.5
UBA52 -6866.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS25 -7230.5
RPL35 -7204.5
RPL35A -7174.5
RPS13 -7171.5
RPL37 -7150.5
RPS8 -7146.5
RPS12 -7128.5
RPL26 -7115.5
RPL32 -7108.5
RPL27A -7094.5
RPL37A -7084.5
RPL36AL -7021.5
RPL34 -6992.5
RPS24 -6965.5
RPS6 -6945.5
RPS20 -6935.5
RPS18 -6907.5
RPS17 -6897.5
RPS21 -6874.5
UBA52 -6866.5
RPS16 -6775.5
RPL11 -6771.5
RPL28 -6747.5
RPL19 -6743.5
RPLP1 -6723.5
RPL13 -6699.5
RPL36 -6698.5
RPL12 -6686.5
RPL18 -6683.5
RPL30 -6654.5
RPS15A -6643.5
RPL14 -6622.5
RPL29 -6611.5
RPS5 -6609.5
RPS27A -6566.5
RPL6 -6518.5
RPLP0 -6505.5
RPS27L -6442.5
RPL5 -6328.5
RPL41 -6326.5
RPL27 -6274.5
RPL38 -6203.5
RPS19 -6200.5
FAU -6193.5
RPL10A -6180.5
RPS2 -6131.5
RPLP2 -6111.5
RPL31 -6066.5
RPS11 -5965.5
RPL23 -5877.5
RPS4X -5702.5
RPL13A -5655.5
RPS14 -5637.5
RPS7 -5383.5
RPS29 -5338.5
RPL15 -5180.5
RPS10 -5037.5
RPL4 -4739.5
RPL36A -4638.5
RPS3 -4564.5
RPL8 -4521.5
RPS9 -4369.5
RPL7A -4346.5
RPS15 -4298.5
RPS26 -4234.5
RPL24 -4179.5
RPS23 -4169.5
RPL39 -4091.5
RPL22 -3933.5
RPL10 -3823.5
RPS28 -3737.5
RPL18A -2379.5
RPL3L -2256.5
RPSA -1706.5
RPL23A -1308.5
RPS27 -993.5
RPL26L1 319.5
RPL9 469.5
RPS4Y1 549.5
GRSF1 953.5
RPL22L1 1190.5
RPS3A 1867.5
RPL3 3111.5
RPL21 4530.5
RPL17 5016.5
DNAJC3 6112.5
RPL7 6867.5


Eukaryotic Translation Elongation
set Eukaryotic Translation Elongation
setSize 91
pANOVA 6.79e-27
s.dist -0.651
p.adjustANOVA 2.79e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS25 -7230.5
RPL35 -7204.5
RPL35A -7174.5
RPS13 -7171.5
RPL37 -7150.5
RPS8 -7146.5
RPS12 -7128.5
RPL26 -7115.5
RPL32 -7108.5
RPL27A -7094.5
RPL37A -7084.5
RPL36AL -7021.5
RPL34 -6992.5
RPS24 -6965.5
RPS6 -6945.5
RPS20 -6935.5
RPS18 -6907.5
RPS17 -6897.5
RPS21 -6874.5
UBA52 -6866.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS25 -7230.5
RPL35 -7204.5
RPL35A -7174.5
RPS13 -7171.5
RPL37 -7150.5
RPS8 -7146.5
RPS12 -7128.5
RPL26 -7115.5
RPL32 -7108.5
RPL27A -7094.5
RPL37A -7084.5
RPL36AL -7021.5
RPL34 -6992.5
RPS24 -6965.5
RPS6 -6945.5
RPS20 -6935.5
RPS18 -6907.5
RPS17 -6897.5
RPS21 -6874.5
UBA52 -6866.5
RPS16 -6775.5
RPL11 -6771.5
RPL28 -6747.5
RPL19 -6743.5
RPLP1 -6723.5
RPL13 -6699.5
RPL36 -6698.5
RPL12 -6686.5
RPL18 -6683.5
RPL30 -6654.5
RPS15A -6643.5
RPL14 -6622.5
RPL29 -6611.5
RPS5 -6609.5
RPS27A -6566.5
RPL6 -6518.5
RPLP0 -6505.5
RPS27L -6442.5
RPL5 -6328.5
RPL41 -6326.5
RPL27 -6274.5
EEF1B2 -6227.5
RPL38 -6203.5
RPS19 -6200.5
FAU -6193.5
RPL10A -6180.5
RPS2 -6131.5
RPLP2 -6111.5
RPL31 -6066.5
RPS11 -5965.5
RPL23 -5877.5
RPS4X -5702.5
RPL13A -5655.5
RPS14 -5637.5
RPS7 -5383.5
RPS29 -5338.5
RPL15 -5180.5
RPS10 -5037.5
RPL4 -4739.5
RPL36A -4638.5
RPS3 -4564.5
RPL8 -4521.5
RPS9 -4369.5
RPL7A -4346.5
RPS15 -4298.5
RPS26 -4234.5
RPL24 -4179.5
RPS23 -4169.5
RPL39 -4091.5
RPL22 -3933.5
RPL10 -3823.5
RPS28 -3737.5
EEF1A1P5 -3628.5
EEF1D -2674.5
RPL18A -2379.5
RPL3L -2256.5
RPSA -1706.5
RPL23A -1308.5
RPS27 -993.5
EEF1A1 81.5
RPL26L1 319.5
RPL9 469.5
RPS4Y1 549.5
RPL22L1 1190.5
EEF1A2 1665.5
EEF2 1812.5
RPS3A 1867.5
RPL3 3111.5
RPL21 4530.5
RPL17 5016.5
RPL7 6867.5


Selenocysteine synthesis
set Selenocysteine synthesis
setSize 91
pANOVA 2.13e-26
s.dist -0.644
p.adjustANOVA 5.25e-24


Top enriched genes
Top 20 genes
GeneID Gene Rank
RPS25 -7230.5
RPL35 -7204.5
RPL35A -7174.5
RPS13 -7171.5
RPL37 -7150.5
RPS8 -7146.5
RPS12 -7128.5
RPL26 -7115.5
RPL32 -7108.5
RPL27A -7094.5
RPL37A -7084.5
RPL36AL -7021.5
RPL34 -6992.5
RPS24 -6965.5
RPS6 -6945.5
RPS20 -6935.5
RPS18 -6907.5
RPS17 -6897.5
RPS21 -6874.5
UBA52 -6866.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS25 -7230.5
RPL35 -7204.5
RPL35A -7174.5
RPS13 -7171.5
RPL37 -7150.5
RPS8 -7146.5
RPS12 -7128.5
RPL26 -7115.5
RPL32 -7108.5
RPL27A -7094.5
RPL37A -7084.5
RPL36AL -7021.5
RPL34 -6992.5
RPS24 -6965.5
RPS6 -6945.5
RPS20 -6935.5
RPS18 -6907.5
RPS17 -6897.5
RPS21 -6874.5
UBA52 -6866.5
RPS16 -6775.5
RPL11 -6771.5
RPL28 -6747.5
RPL19 -6743.5
RPLP1 -6723.5
RPL13 -6699.5
RPL36 -6698.5
RPL12 -6686.5
RPL18 -6683.5
RPL30 -6654.5
RPS15A -6643.5
RPL14 -6622.5
RPL29 -6611.5
RPS5 -6609.5
RPS27A -6566.5
RPL6 -6518.5
RPLP0 -6505.5
RPS27L -6442.5
RPL5 -6328.5
RPL41 -6326.5
RPL27 -6274.5
RPL38 -6203.5
RPS19 -6200.5
FAU -6193.5
RPL10A -6180.5
RPS2 -6131.5
RPLP2 -6111.5
RPL31 -6066.5
RPS11 -5965.5
RPL23 -5877.5
RPS4X -5702.5
RPL13A -5655.5
SARS -5651.5
RPS14 -5637.5
RPS7 -5383.5
RPS29 -5338.5
RPL15 -5180.5
EEFSEC -5158.5
RPS10 -5037.5
RPL4 -4739.5
RPL36A -4638.5
RPS3 -4564.5
RPL8 -4521.5
RPS9 -4369.5
RPL7A -4346.5
RPS15 -4298.5
RPS26 -4234.5
RPL24 -4179.5
RPS23 -4169.5
RPL39 -4091.5
RPL22 -3933.5
RPL10 -3823.5
RPS28 -3737.5
RPL18A -2379.5
RPL3L -2256.5
SEPSECS -1782.5
RPSA -1706.5
RPL23A -1308.5
RPS27 -993.5
RPL26L1 319.5
RPL9 469.5
RPS4Y1 549.5
SECISBP2 960.5
RPL22L1 1190.5
SEPHS2 1636.5
RPS3A 1867.5
RPL3 3111.5
RPL21 4530.5
RPL17 5016.5
PSTK 5285.5
RPL7 6867.5


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.3 (2024-02-29)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] mitch_1.15.3     kableExtra_1.4.0 pkgload_1.3.4    GGally_2.2.1    
##  [5] ggplot2_3.5.0    reshape2_1.4.4   beeswarm_0.4.0   gplots_3.1.3.1  
##  [9] gtools_3.9.5     tibble_3.2.1     dplyr_1.1.4      echarts4r_0.4.5 
## 
## loaded via a namespace (and not attached):
##  [1] gtable_0.3.4       xfun_0.43          bslib_0.7.0        htmlwidgets_1.6.4 
##  [5] caTools_1.18.2     vctrs_0.6.5        tools_4.3.3        bitops_1.0-7      
##  [9] generics_0.1.3     parallel_4.3.3     fansi_1.0.6        highr_0.10        
## [13] pkgconfig_2.0.3    KernSmooth_2.23-22 RColorBrewer_1.1-3 lifecycle_1.0.4   
## [17] compiler_4.3.3     stringr_1.5.1      munsell_0.5.1      httpuv_1.6.15     
## [21] htmltools_0.5.8.1  sass_0.4.9         yaml_2.3.8         later_1.3.2       
## [25] pillar_1.9.0       jquerylib_0.1.4    tidyr_1.3.1        MASS_7.3-60.0.1   
## [29] cachem_1.0.8       mime_0.12          ggstats_0.6.0      tidyselect_1.2.1  
## [33] digest_0.6.35      stringi_1.8.3      purrr_1.0.2        fastmap_1.1.1     
## [37] grid_4.3.3         colorspace_2.1-0   cli_3.6.2          magrittr_2.0.3    
## [41] utf8_1.2.4         withr_3.0.0        scales_1.3.0       promises_1.3.0    
## [45] rmarkdown_2.26     gridExtra_2.3      shiny_1.8.1.1      evaluate_0.23     
## [49] knitr_1.46         viridisLite_0.4.2  rlang_1.1.3        Rcpp_1.0.12       
## [53] xtable_1.8-4       glue_1.7.0         xml2_1.3.6         svglite_2.1.3     
## [57] rstudioapi_0.16.0  jsonlite_1.8.8     R6_2.5.1           plyr_1.8.9        
## [61] systemfonts_1.0.6

END of report