Mitch Report

date generated: 2020-06-03

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                        ab        d36
## 0610009B22Rik -0.30243426  0.9139299
## 0610009E02Rik  0.07205254 -0.8740584
## 0610009L18Rik -0.82607610 -0.6984798
## 0610010F05Rik  0.45523981  1.7576230
## 0610010K14Rik -0.96139367 -1.5168102
## 0610012G03Rik -0.80991370 -1.7438548

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	11874
duplicated_genes_present	0
num_profile_genes_in_sets	6425
num_profile_genes_not_in_sets	5449
profile_pearson_correl	-0.09899
profile_spearman_correl	-0.09995

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: gsets/ReactomePathways_mouse.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2339
num_genesets_excluded	1105
num_genesets_included	1234

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 213

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.ab	s.d36	p.ab	p.d36
PI-3K-cascade:FGFR2	10	1.14e-03	1.05e-02	0.696	-0.284000	0.6350	0.119000	5.10e-04
PI-3K-cascade:FGFR4	10	1.14e-03	1.05e-02	0.696	-0.284000	0.6350	0.119000	5.10e-04
Regulation-of-pyruvate-dehydrogenase-(PDH)-complex	15	4.78e-05	9.51e-04	0.677	-0.158000	0.6590	0.288000	1.00e-05
Biotin-transport-and-metabolism	11	9.32e-04	9.26e-03	0.652	-0.043700	0.6500	0.802000	1.89e-04
Peptide-chain-elongation	69	2.23e-18	7.36e-16	0.625	0.004000	-0.6250	0.954000	2.79e-19
Branched-chain-amino-acid-catabolism	20	1.11e-05	2.79e-04	0.614	0.000211	0.6140	0.999000	2.00e-06
Citric-acid-cycle-(TCA-cycle)	22	1.42e-05	3.50e-04	0.608	-0.350000	0.4980	0.004520	5.33e-05
Carnitine-metabolism	12	1.24e-03	1.10e-02	0.603	0.042900	0.6010	0.797000	3.12e-04
Viral-mRNA-Translation	69	3.98e-17	6.45e-15	0.602	-0.001100	-0.6020	0.987000	5.35e-18
Eukaryotic-Translation-Elongation	73	1.21e-17	2.99e-15	0.595	0.005690	-0.5950	0.933000	1.49e-18
Eukaryotic-Translation-Termination	72	3.35e-17	6.45e-15	0.588	-0.021500	-0.5880	0.753000	6.16e-18
Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency	80	1.58e-18	7.36e-16	0.587	0.045700	-0.5850	0.481000	1.40e-19
Selenocysteine-synthesis	73	4.18e-17	6.45e-15	0.584	-0.009570	-0.5840	0.888000	6.35e-18
Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)	73	2.35e-16	3.22e-14	0.570	-0.018600	-0.5690	0.783000	4.12e-17
Physiological-factors	11	2.73e-03	2.01e-02	0.569	0.327000	0.4660	0.060300	7.49e-03
Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle	50	2.52e-10	1.15e-08	0.567	-0.305000	0.4780	0.000190	5.06e-09
PI-3K-cascade:FGFR3	11	8.02e-03	4.71e-02	0.562	-0.265000	0.4960	0.128000	4.42e-03
Constitutive-Signaling-by-NOTCH1-HD-Domain-Mutants	14	7.28e-04	7.88e-03	0.557	-0.379000	-0.4080	0.014100	8.27e-03
Signaling-by-NOTCH1-HD-Domain-Mutants-in-Cancer	14	7.28e-04	7.88e-03	0.557	-0.379000	-0.4080	0.014100	8.27e-03
PI-3K-cascade:FGFR1	10	1.41e-02	7.21e-02	0.547	-0.168000	0.5200	0.356000	4.41e-03
Prolactin-receptor-signaling	10	1.02e-02	5.65e-02	0.532	0.206000	0.4900	0.258000	7.29e-03
eNOS-activation	11	9.90e-03	5.53e-02	0.527	0.005080	-0.5270	0.977000	2.48e-03
CS/DS-degradation	10	2.50e-02	1.08e-01	0.520	0.338000	-0.3950	0.064300	3.06e-02
Formation-of-a-pool-of-free-40S-subunits	81	4.27e-15	4.79e-13	0.516	-0.044500	-0.5140	0.489000	1.29e-15
Voltage-gated-Potassium-channels	13	7.56e-03	4.53e-02	0.516	-0.185000	0.4810	0.248000	2.65e-03
SRP-dependent-cotranslational-protein-targeting-to-membrane	92	4.84e-16	5.97e-14	0.509	0.043000	-0.5070	0.477000	4.57e-17
G-beta:gamma-signalling-through-BTK	11	2.10e-02	9.63e-02	0.508	0.371000	-0.3460	0.033100	4.68e-02
Activation-of-G-protein-gated-Potassium-channels	16	2.91e-03	2.10e-02	0.501	0.491000	-0.1000	0.000676	4.88e-01
G-protein-gated-Potassium-channels	16	2.91e-03	2.10e-02	0.501	0.491000	-0.1000	0.000676	4.88e-01
Inhibition--of-voltage-gated-Ca2+-channels-via-Gbeta/gamma-subunits	16	2.91e-03	2.10e-02	0.501	0.491000	-0.1000	0.000676	4.88e-01
Acyl-chain-remodelling-of-PE	13	4.41e-03	3.04e-02	0.501	0.378000	0.3280	0.018200	4.07e-02
G-protein-activation	15	7.14e-03	4.30e-02	0.489	0.414000	-0.2600	0.005490	8.13e-02
Pyruvate-metabolism	26	2.23e-04	3.02e-03	0.484	-0.246000	0.4170	0.030100	2.34e-04
Collagen-chain-trimerization	25	9.17e-05	1.57e-03	0.483	-0.135000	-0.4640	0.244000	5.97e-05
ADP-signalling-through-P2Y-purinoceptor-12	14	1.18e-02	6.34e-02	0.481	0.388000	-0.2840	0.011900	6.55e-02
Thrombin-signalling-through-proteinase-activated-receptors-(PARs)	21	1.37e-03	1.16e-02	0.480	0.336000	-0.3430	0.007640	6.56e-03
Interleukin-7-signaling	15	9.26e-03	5.27e-02	0.478	-0.375000	0.2960	0.011900	4.73e-02
Selenoamino-acid-metabolism	90	2.44e-14	2.51e-12	0.478	-0.030700	-0.4770	0.616000	5.65e-15
G-beta:gamma-signalling-through-CDC42	13	1.79e-02	8.54e-02	0.477	0.326000	-0.3480	0.041900	2.99e-02
G-beta:gamma-signalling-through-PLC-beta	14	1.23e-02	6.52e-02	0.476	0.422000	-0.2200	0.006270	1.55e-01
Presynaptic-function-of-Kainate-receptors	14	1.23e-02	6.52e-02	0.476	0.422000	-0.2200	0.006270	1.55e-01
Basigin-interactions	18	4.17e-03	2.91e-02	0.473	0.343000	-0.3260	0.011800	1.68e-02
Synthesis-of-Prostaglandins-(PG)-and-Thromboxanes-(TX)	10	4.82e-02	1.71e-01	0.472	0.351000	-0.3150	0.054800	8.46e-02
Interferon-alpha/beta-signaling	35	4.73e-06	1.33e-04	0.468	-0.144000	-0.4450	0.141000	5.18e-06
Metabolism-of-nitric-oxide:-eNOS-activation-and-regulation	15	6.48e-03	3.98e-02	0.467	-0.046100	-0.4640	0.757000	1.85e-03
MECP2-regulates-neuronal-receptors-and-channels	11	2.63e-02	1.13e-01	0.463	0.462000	0.0407	0.008030	8.15e-01
Caspase-mediated-cleavage-of-cytoskeletal-proteins	12	2.30e-02	1.02e-01	0.462	0.060700	-0.4580	0.716000	6.04e-03
Scavenging-by-Class-A-Receptors	14	7.67e-03	4.55e-02	0.461	-0.215000	-0.4070	0.163000	8.32e-03
Peroxisomal-protein-import	52	1.80e-07	7.16e-06	0.460	-0.157000	0.4320	0.050700	7.11e-08
Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)	92	3.46e-13	2.84e-11	0.455	-0.001870	-0.4550	0.975000	4.91e-14

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.ab	s.d36	p.ab	p.d36
PI-3K-cascade:FGFR2	10	1.14e-03	1.05e-02	0.69600	-0.284000	6.35e-01	1.19e-01	5.10e-04
PI-3K-cascade:FGFR4	10	1.14e-03	1.05e-02	0.69600	-0.284000	6.35e-01	1.19e-01	5.10e-04
Regulation-of-pyruvate-dehydrogenase-(PDH)-complex	15	4.78e-05	9.51e-04	0.67700	-0.158000	6.59e-01	2.88e-01	1.00e-05
Biotin-transport-and-metabolism	11	9.32e-04	9.26e-03	0.65200	-0.043700	6.50e-01	8.02e-01	1.89e-04
Peptide-chain-elongation	69	2.23e-18	7.36e-16	0.62500	0.004000	-6.25e-01	9.54e-01	2.79e-19
Branched-chain-amino-acid-catabolism	20	1.11e-05	2.79e-04	0.61400	0.000211	6.14e-01	9.99e-01	2.00e-06
Citric-acid-cycle-(TCA-cycle)	22	1.42e-05	3.50e-04	0.60800	-0.350000	4.98e-01	4.52e-03	5.33e-05
Carnitine-metabolism	12	1.24e-03	1.10e-02	0.60300	0.042900	6.01e-01	7.97e-01	3.12e-04
Viral-mRNA-Translation	69	3.98e-17	6.45e-15	0.60200	-0.001100	-6.02e-01	9.87e-01	5.35e-18
Eukaryotic-Translation-Elongation	73	1.21e-17	2.99e-15	0.59500	0.005690	-5.95e-01	9.33e-01	1.49e-18
Eukaryotic-Translation-Termination	72	3.35e-17	6.45e-15	0.58800	-0.021500	-5.88e-01	7.53e-01	6.16e-18
Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency	80	1.58e-18	7.36e-16	0.58700	0.045700	-5.85e-01	4.81e-01	1.40e-19
Selenocysteine-synthesis	73	4.18e-17	6.45e-15	0.58400	-0.009570	-5.84e-01	8.88e-01	6.35e-18
Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)	73	2.35e-16	3.22e-14	0.57000	-0.018600	-5.69e-01	7.83e-01	4.12e-17
Physiological-factors	11	2.73e-03	2.01e-02	0.56900	0.327000	4.66e-01	6.03e-02	7.49e-03
Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle	50	2.52e-10	1.15e-08	0.56700	-0.305000	4.78e-01	1.90e-04	5.06e-09
PI-3K-cascade:FGFR3	11	8.02e-03	4.71e-02	0.56200	-0.265000	4.96e-01	1.28e-01	4.42e-03
Constitutive-Signaling-by-NOTCH1-HD-Domain-Mutants	14	7.28e-04	7.88e-03	0.55700	-0.379000	-4.08e-01	1.41e-02	8.27e-03
Signaling-by-NOTCH1-HD-Domain-Mutants-in-Cancer	14	7.28e-04	7.88e-03	0.55700	-0.379000	-4.08e-01	1.41e-02	8.27e-03
PI-3K-cascade:FGFR1	10	1.41e-02	7.21e-02	0.54700	-0.168000	5.20e-01	3.56e-01	4.41e-03
Prolactin-receptor-signaling	10	1.02e-02	5.65e-02	0.53200	0.206000	4.90e-01	2.58e-01	7.29e-03
eNOS-activation	11	9.90e-03	5.53e-02	0.52700	0.005080	-5.27e-01	9.77e-01	2.48e-03
CS/DS-degradation	10	2.50e-02	1.08e-01	0.52000	0.338000	-3.95e-01	6.43e-02	3.06e-02
Formation-of-a-pool-of-free-40S-subunits	81	4.27e-15	4.79e-13	0.51600	-0.044500	-5.14e-01	4.89e-01	1.29e-15
Voltage-gated-Potassium-channels	13	7.56e-03	4.53e-02	0.51600	-0.185000	4.81e-01	2.48e-01	2.65e-03
SRP-dependent-cotranslational-protein-targeting-to-membrane	92	4.84e-16	5.97e-14	0.50900	0.043000	-5.07e-01	4.77e-01	4.57e-17
G-beta:gamma-signalling-through-BTK	11	2.10e-02	9.63e-02	0.50800	0.371000	-3.46e-01	3.31e-02	4.68e-02
Activation-of-G-protein-gated-Potassium-channels	16	2.91e-03	2.10e-02	0.50100	0.491000	-1.00e-01	6.76e-04	4.88e-01
G-protein-gated-Potassium-channels	16	2.91e-03	2.10e-02	0.50100	0.491000	-1.00e-01	6.76e-04	4.88e-01
Inhibition--of-voltage-gated-Ca2+-channels-via-Gbeta/gamma-subunits	16	2.91e-03	2.10e-02	0.50100	0.491000	-1.00e-01	6.76e-04	4.88e-01
Acyl-chain-remodelling-of-PE	13	4.41e-03	3.04e-02	0.50100	0.378000	3.28e-01	1.82e-02	4.07e-02
G-protein-activation	15	7.14e-03	4.30e-02	0.48900	0.414000	-2.60e-01	5.49e-03	8.13e-02
Pyruvate-metabolism	26	2.23e-04	3.02e-03	0.48400	-0.246000	4.17e-01	3.01e-02	2.34e-04
Collagen-chain-trimerization	25	9.17e-05	1.57e-03	0.48300	-0.135000	-4.64e-01	2.44e-01	5.97e-05
ADP-signalling-through-P2Y-purinoceptor-12	14	1.18e-02	6.34e-02	0.48100	0.388000	-2.84e-01	1.19e-02	6.55e-02
Thrombin-signalling-through-proteinase-activated-receptors-(PARs)	21	1.37e-03	1.16e-02	0.48000	0.336000	-3.43e-01	7.64e-03	6.56e-03
Interleukin-7-signaling	15	9.26e-03	5.27e-02	0.47800	-0.375000	2.96e-01	1.19e-02	4.73e-02
Selenoamino-acid-metabolism	90	2.44e-14	2.51e-12	0.47800	-0.030700	-4.77e-01	6.16e-01	5.65e-15
G-beta:gamma-signalling-through-CDC42	13	1.79e-02	8.54e-02	0.47700	0.326000	-3.48e-01	4.19e-02	2.99e-02
G-beta:gamma-signalling-through-PLC-beta	14	1.23e-02	6.52e-02	0.47600	0.422000	-2.20e-01	6.27e-03	1.55e-01
Presynaptic-function-of-Kainate-receptors	14	1.23e-02	6.52e-02	0.47600	0.422000	-2.20e-01	6.27e-03	1.55e-01
Basigin-interactions	18	4.17e-03	2.91e-02	0.47300	0.343000	-3.26e-01	1.18e-02	1.68e-02
Synthesis-of-Prostaglandins-(PG)-and-Thromboxanes-(TX)	10	4.82e-02	1.71e-01	0.47200	0.351000	-3.15e-01	5.48e-02	8.46e-02
Interferon-alpha/beta-signaling	35	4.73e-06	1.33e-04	0.46800	-0.144000	-4.45e-01	1.41e-01	5.18e-06
Metabolism-of-nitric-oxide:-eNOS-activation-and-regulation	15	6.48e-03	3.98e-02	0.46700	-0.046100	-4.64e-01	7.57e-01	1.85e-03
MECP2-regulates-neuronal-receptors-and-channels	11	2.63e-02	1.13e-01	0.46300	0.462000	4.07e-02	8.03e-03	8.15e-01
Caspase-mediated-cleavage-of-cytoskeletal-proteins	12	2.30e-02	1.02e-01	0.46200	0.060700	-4.58e-01	7.16e-01	6.04e-03
Scavenging-by-Class-A-Receptors	14	7.67e-03	4.55e-02	0.46100	-0.215000	-4.07e-01	1.63e-01	8.32e-03
Peroxisomal-protein-import	52	1.80e-07	7.16e-06	0.46000	-0.157000	4.32e-01	5.07e-02	7.11e-08
Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)	92	3.46e-13	2.84e-11	0.45500	-0.001870	-4.55e-01	9.75e-01	4.91e-14
Nonsense-Mediated-Decay-(NMD)	92	3.46e-13	2.84e-11	0.45500	-0.001870	-4.55e-01	9.75e-01	4.91e-14
YAP1--and-WWTR1-(TAZ)-stimulated-gene-expression	13	1.52e-02	7.65e-02	0.45200	0.101000	4.40e-01	5.28e-01	6.01e-03
Collagen-biosynthesis-and-modifying-enzymes	45	5.65e-07	2.05e-05	0.45000	-0.098500	-4.40e-01	2.53e-01	3.40e-07
Attenuation-phase	21	1.31e-03	1.13e-02	0.45000	-0.445000	-7.01e-02	4.21e-04	5.78e-01
Binding-and-Uptake-of-Ligands-by-Scavenger-Receptors	27	1.29e-04	1.99e-03	0.44700	-0.272000	-3.55e-01	1.44e-02	1.42e-03
tRNA-processing-in-the-mitochondrion	17	5.86e-03	3.69e-02	0.44600	0.008350	4.46e-01	9.52e-01	1.45e-03
Smooth-Muscle-Contraction	29	1.95e-04	2.73e-03	0.44600	0.042800	-4.44e-01	6.90e-01	3.57e-05
Thromboxane-signalling-through-TP-receptor	15	1.64e-02	8.14e-02	0.44500	0.223000	-3.85e-01	1.35e-01	9.80e-03
Chondroitin-sulfate-biosynthesis	14	2.30e-02	1.02e-01	0.44400	0.349000	-2.75e-01	2.38e-02	7.54e-02
Synthesis-of-PA	26	2.08e-04	2.85e-03	0.44400	0.357000	2.64e-01	1.65e-03	2.00e-02
L13a-mediated-translational-silencing-of-Ceruloplasmin-expression	90	1.36e-12	7.96e-11	0.44100	-0.081900	-4.33e-01	1.80e-01	1.25e-12
Activation-of-kainate-receptors-upon-glutamate-binding	20	5.24e-03	3.47e-02	0.43900	0.339000	-2.78e-01	8.64e-03	3.14e-02
Glucagon-type-ligand-receptors	13	3.27e-02	1.32e-01	0.43800	0.263000	-3.51e-01	1.01e-01	2.85e-02
GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit	92	1.18e-12	7.30e-11	0.43800	-0.072000	-4.32e-01	2.34e-01	8.16e-13
Gap-junction-trafficking	13	2.17e-02	9.79e-02	0.43700	-0.041500	-4.35e-01	7.96e-01	6.59e-03
Glycogen-breakdown-(glycogenolysis)	14	2.21e-02	9.94e-02	0.43600	-0.126000	4.18e-01	4.14e-01	6.80e-03
Formation-of-tubulin-folding-intermediates-by-CCT/TriC	16	6.62e-03	4.04e-02	0.43400	-0.304000	-3.10e-01	3.52e-02	3.21e-02
Post-chaperonin-tubulin-folding-pathway	14	2.13e-02	9.71e-02	0.43200	0.062100	-4.28e-01	6.87e-01	5.58e-03
Retrograde-neurotrophin-signalling	12	2.66e-02	1.14e-01	0.42800	-0.370000	-2.16e-01	2.65e-02	1.95e-01
HDMs-demethylate-histones	21	4.97e-03	3.33e-02	0.42800	-0.227000	3.63e-01	7.13e-02	3.99e-03
Prostacyclin-signalling-through-prostacyclin-receptor	13	3.77e-02	1.45e-01	0.42800	0.236000	-3.58e-01	1.41e-01	2.56e-02
Immunoregulatory-interactions-between-a-Lymphoid-and-a-non-Lymphoid-cell	24	1.23e-03	1.10e-02	0.42700	-0.023700	-4.27e-01	8.41e-01	2.99e-04
rRNA-processing-in-the-mitochondrion	20	4.22e-03	2.93e-02	0.42700	-0.019900	4.27e-01	8.78e-01	9.59e-04
GABA-receptor-activation	29	3.69e-04	4.46e-03	0.42700	0.426000	-2.33e-02	7.12e-05	8.28e-01
Cap-dependent-Translation-Initiation	98	9.15e-13	5.95e-11	0.42500	-0.090500	-4.15e-01	1.22e-01	1.32e-12
Eukaryotic-Translation-Initiation	98	9.15e-13	5.95e-11	0.42500	-0.090500	-4.15e-01	1.22e-01	1.32e-12
Phase-2---plateau-phase	12	4.34e-02	1.60e-01	0.42400	-0.089700	4.15e-01	5.90e-01	1.29e-02
ABC-transporters-in-lipid-homeostasis	13	3.07e-02	1.27e-01	0.42400	-0.030500	4.23e-01	8.49e-01	8.33e-03
Defective-B4GALT7-causes-EDS,-progeroid-type	15	2.05e-02	9.46e-02	0.41900	0.048100	-4.16e-01	7.47e-01	5.32e-03
KSRP-(KHSRP)-binds-and-destabilizes-mRNA	15	1.30e-02	6.75e-02	0.41800	-0.340000	-2.43e-01	2.27e-02	1.03e-01
HSF1-dependent-transactivation	31	4.42e-04	5.29e-03	0.41700	-0.402000	1.11e-01	1.09e-04	2.83e-01
Uptake-and-function-of-anthrax-toxins	11	7.47e-02	2.34e-01	0.41500	-0.243000	3.36e-01	1.63e-01	5.35e-02
Activated-NOTCH1-Transmits-Signal-to-the-Nucleus	26	9.04e-04	9.07e-03	0.41400	-0.087600	-4.04e-01	4.40e-01	3.60e-04
Defective-B3GAT3-causes-JDSSDHD	15	2.16e-02	9.79e-02	0.41300	0.022500	-4.13e-01	8.80e-01	5.67e-03
Glutathione-synthesis-and-recycling	10	9.07e-02	2.61e-01	0.41200	-0.150000	3.84e-01	4.11e-01	3.55e-02
NOTCH4-Activation-and-Transmission-of-Signal-to-the-Nucleus	10	8.05e-02	2.45e-01	0.41200	0.042600	-4.10e-01	8.16e-01	2.48e-02
Sema3A-PAK-dependent-Axon-repulsion	12	3.40e-02	1.35e-01	0.41100	-0.285000	-2.97e-01	8.73e-02	7.53e-02
Mitochondrial-Fatty-Acid-Beta-Oxidation	30	7.54e-04	7.95e-03	0.41100	-0.133000	3.89e-01	2.08e-01	2.29e-04
Activation-of-GABAB-receptors	26	1.69e-03	1.33e-02	0.41000	0.404000	-7.09e-02	3.67e-04	5.32e-01
GABA-B-receptor-activation	26	1.69e-03	1.33e-02	0.41000	0.404000	-7.09e-02	3.67e-04	5.32e-01
EPHA-mediated-growth-cone-collapse	13	4.03e-02	1.51e-01	0.40800	0.038600	-4.06e-01	8.10e-01	1.13e-02
Mitochondrial-tRNA-aminoacylation	19	1.35e-02	6.93e-02	0.40800	-0.305000	2.71e-01	2.15e-02	4.11e-02
Major-pathway-of-rRNA-processing-in-the-nucleolus-and-cytosol	153	2.39e-18	7.36e-16	0.40700	-0.140000	-3.83e-01	2.80e-03	3.56e-16
Defects-in-vitamin-and-cofactor-metabolism	19	9.41e-03	5.33e-02	0.40700	-0.041100	4.05e-01	7.57e-01	2.25e-03
Defective-B3GALT6-causes-EDSP2-and-SEMDJL1	15	2.94e-02	1.24e-01	0.40500	0.115000	-3.89e-01	4.39e-01	9.17e-03
Heme-biosynthesis	11	7.77e-02	2.41e-01	0.40500	-0.381000	1.35e-01	2.85e-02	4.39e-01
Cooperation-of-Prefoldin-and-TriC/CCT--in-actin-and-tubulin-folding	23	2.13e-03	1.63e-02	0.40400	-0.187000	-3.58e-01	1.21e-01	2.94e-03
Generation-of-second-messenger-molecules	12	3.89e-02	1.47e-01	0.40300	-0.305000	-2.64e-01	6.73e-02	1.14e-01
Signaling-by-NODAL	11	8.68e-02	2.56e-01	0.40200	-0.337000	2.20e-01	5.32e-02	2.07e-01
Repression-of-WNT-target-genes	11	8.99e-02	2.61e-01	0.40000	0.248000	-3.14e-01	1.55e-01	7.10e-02
AUF1-(hnRNP-D0)-binds-and-destabilizes-mRNA	50	3.79e-06	1.15e-04	0.39800	-0.389000	-8.49e-02	1.94e-06	3.00e-01
Cholesterol-biosynthesis	21	5.83e-03	3.69e-02	0.39800	0.395000	4.48e-02	1.71e-03	7.22e-01
Initial-triggering-of-complement	11	6.04e-02	2.00e-01	0.39800	-0.141000	-3.72e-01	4.17e-01	3.28e-02
Metabolism-of-folate-and-pterines	13	3.78e-02	1.45e-01	0.39700	0.379000	1.17e-01	1.79e-02	4.66e-01
rRNA-processing-in-the-nucleus-and-cytosol	163	1.66e-18	7.36e-16	0.39500	-0.160000	-3.61e-01	4.26e-04	2.10e-15
SHC1-events-in-ERBB4-signaling	10	1.15e-01	3.01e-01	0.39400	0.356000	-1.69e-01	5.14e-02	3.55e-01
RHO-GTPases-activate-PAKs	19	1.64e-02	8.14e-02	0.39400	0.169000	-3.56e-01	2.03e-01	7.30e-03
Purine-ribonucleoside-monophosphate-biosynthesis	12	6.21e-02	2.05e-01	0.39300	-0.393000	2.06e-02	1.85e-02	9.02e-01
FRS-mediated-FGFR2-signaling	12	7.97e-02	2.44e-01	0.39100	-0.212000	3.29e-01	2.03e-01	4.86e-02
FRS-mediated-FGFR4-signaling	12	7.97e-02	2.44e-01	0.39100	-0.212000	3.29e-01	2.03e-01	4.86e-02
p75NTR-signals-via-NF-kB	14	3.80e-02	1.45e-01	0.39000	-0.024500	-3.90e-01	8.74e-01	1.16e-02
NOTCH2-Activation-and-Transmission-of-Signal-to-the-Nucleus	19	9.19e-03	5.27e-02	0.39000	-0.158000	-3.56e-01	2.32e-01	7.22e-03
Influenza-Viral-RNA-Transcription-and-Replication	111	6.16e-12	3.30e-10	0.38900	-0.040400	-3.87e-01	4.63e-01	1.95e-12
Glyoxylate-metabolism-and-glycine-degradation	22	8.18e-03	4.76e-02	0.38800	-0.081600	3.79e-01	5.08e-01	2.07e-03
Glycosphingolipid-metabolism	30	1.73e-03	1.35e-02	0.38500	0.369000	-1.11e-01	4.74e-04	2.92e-01
NF-kB-is-activated-and-signals-survival	11	8.24e-02	2.51e-01	0.38300	-0.037200	-3.82e-01	8.31e-01	2.84e-02
A-tetrasaccharide-linker-sequence-is-required-for-GAG-synthesis	20	1.31e-02	6.77e-02	0.38300	0.042100	-3.80e-01	7.45e-01	3.24e-03
Prefoldin-mediated-transfer-of-substrate--to-CCT/TriC	21	6.43e-03	3.97e-02	0.38200	-0.198000	-3.27e-01	1.16e-01	9.59e-03
Molecules-associated-with-elastic-fibres	25	4.54e-03	3.09e-02	0.38000	0.379000	-2.34e-02	1.03e-03	8.39e-01
Assembly-of-collagen-fibrils-and-other-multimeric-structures	40	8.71e-05	1.56e-03	0.38000	-0.153000	-3.47e-01	9.38e-02	1.46e-04
Golgi-Cisternae-Pericentriolar-Stack-Reorganization	10	9.41e-02	2.67e-01	0.37700	0.290000	2.41e-01	1.12e-01	1.88e-01
Pexophagy	10	1.35e-01	3.31e-01	0.37700	-0.350000	1.39e-01	5.51e-02	4.46e-01
TGF-beta-receptor-signaling-in-EMT-(epithelial-to-mesenchymal-transition)	13	6.38e-02	2.08e-01	0.37600	0.018300	-3.75e-01	9.09e-01	1.91e-02
Assembly-of-active-LPL-and-LIPC-lipase-complexes	10	1.42e-01	3.41e-01	0.37600	-0.326000	1.86e-01	7.40e-02	3.09e-01
Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex	44	9.09e-05	1.57e-03	0.37400	-0.000526	-3.74e-01	9.95e-01	1.77e-05
Peroxisomal-lipid-metabolism	23	5.70e-03	3.67e-02	0.37300	0.131000	3.49e-01	2.75e-01	3.74e-03
Gap-junction-trafficking-and-regulation	15	4.37e-02	1.61e-01	0.37300	0.018700	-3.73e-01	9.00e-01	1.24e-02
Synthesis-of-PC	21	9.26e-03	5.27e-02	0.37000	0.158000	3.34e-01	2.09e-01	8.03e-03
Metabolism-of-steroid-hormones	13	8.38e-02	2.53e-01	0.37000	0.333000	-1.61e-01	3.78e-02	3.14e-01
Regulation-of-TP53-Activity-through-Methylation	16	2.97e-02	1.24e-01	0.36900	-0.344000	-1.33e-01	1.72e-02	3.56e-01
Acyl-chain-remodelling-of-PS	11	9.93e-02	2.75e-01	0.36700	0.364000	5.12e-02	3.67e-02	7.69e-01
Acyl-chain-remodelling-of-PC	14	4.42e-02	1.62e-01	0.36700	0.310000	1.97e-01	4.44e-02	2.03e-01
Regulation-of-ornithine-decarboxylase-(ODC)	47	6.05e-05	1.15e-03	0.36700	-0.365000	-3.26e-02	1.49e-05	6.99e-01
rRNA-modification-in-the-nucleus-and-cytosol	53	8.00e-06	2.15e-04	0.36600	-0.297000	-2.13e-01	1.82e-04	7.27e-03
Constitutive-Signaling-by-Overexpressed-ERBB2	11	1.35e-01	3.31e-01	0.36400	0.300000	-2.06e-01	8.48e-02	2.36e-01
TICAM1-dependent-activation-of-IRF3/IRF7	10	1.13e-01	2.99e-01	0.36400	-0.186000	-3.13e-01	3.10e-01	8.62e-02
Inwardly-rectifying-K+-channels	20	2.11e-02	9.67e-02	0.36300	0.358000	-5.71e-02	5.57e-03	6.59e-01
Cristae-formation	13	8.48e-02	2.53e-01	0.36300	-0.086900	3.52e-01	5.87e-01	2.80e-02
Collagen-formation	63	2.23e-06	7.45e-05	0.36200	-0.086800	-3.51e-01	2.34e-01	1.46e-06
Metabolism-of-polyamines	53	2.65e-05	5.95e-04	0.36000	-0.359000	-3.00e-02	6.35e-06	7.06e-01
Regulation-of-activated-PAK-2p34-by-proteasome-mediated-degradation	46	8.95e-05	1.57e-03	0.35900	-0.351000	-7.68e-02	3.93e-05	3.68e-01
Retinoid-metabolism-and-transport	22	1.54e-02	7.75e-02	0.35900	0.046200	-3.56e-01	7.07e-01	3.89e-03
Regulation-of-KIT-signaling	13	6.50e-02	2.10e-01	0.35800	-0.319000	-1.63e-01	4.64e-02	3.08e-01
Influenza-Infection	127	9.15e-12	4.71e-10	0.35800	-0.077700	-3.49e-01	1.31e-01	1.19e-11
p75NTR-recruits-signalling-complexes	11	1.05e-01	2.86e-01	0.35700	-0.118000	-3.37e-01	4.97e-01	5.31e-02
Activation-of-the-AP-1-family-of-transcription-factors	10	1.21e-01	3.12e-01	0.35700	0.272000	2.31e-01	1.37e-01	2.06e-01
tRNA-Aminoacylation	37	1.33e-03	1.13e-02	0.35600	-0.333000	1.27e-01	4.62e-04	1.81e-01
Interleukin-6-signaling	10	1.30e-01	3.28e-01	0.35400	0.150000	3.20e-01	4.12e-01	7.95e-02
Regulation-of-expression-of-SLITs-and-ROBOs	131	5.21e-12	2.92e-10	0.35300	-0.108000	-3.36e-01	3.36e-02	3.16e-11
mRNA-decay-by-3'-to-5'-exoribonuclease	15	4.57e-02	1.63e-01	0.35200	-0.272000	-2.23e-01	6.82e-02	1.35e-01
Cross-presentation-of-soluble-exogenous-antigens-(endosomes)	44	2.02e-04	2.80e-03	0.35100	-0.345000	-6.69e-02	7.62e-05	4.43e-01
Formation-of-the-cornified-envelope	14	9.22e-02	2.64e-01	0.35100	-0.175000	3.04e-01	2.58e-01	4.87e-02
Nitric-oxide-stimulates-guanylate-cyclase	13	1.09e-01	2.94e-01	0.35000	0.157000	-3.13e-01	3.29e-01	5.06e-02
Cytosolic-tRNA-aminoacylation	19	3.08e-02	1.27e-01	0.35000	-0.349000	2.00e-02	8.40e-03	8.80e-01
Synthesis-of-PIPs-at-the-late-endosome-membrane	10	1.47e-01	3.48e-01	0.34900	0.075200	3.40e-01	6.81e-01	6.24e-02
ATF4-activates-genes-in-response-to-endoplasmic-reticulum--stress	23	1.11e-02	6.06e-02	0.34900	-0.123000	-3.26e-01	3.07e-01	6.81e-03
Vif-mediated-degradation-of-APOBEC3G	47	1.29e-04	1.99e-03	0.34800	-0.338000	-8.09e-02	6.16e-05	3.38e-01
NCAM1-interactions	24	8.09e-03	4.73e-02	0.34700	-0.242000	-2.49e-01	4.02e-02	3.47e-02
Ubiquitin-Mediated-Degradation-of-Phosphorylated-Cdc25A	47	1.22e-04	1.98e-03	0.34700	-0.334000	-9.50e-02	7.49e-05	2.60e-01
p53-Independent-DNA-Damage-Response	47	1.22e-04	1.98e-03	0.34700	-0.334000	-9.50e-02	7.49e-05	2.60e-01
p53-Independent-G1/S-DNA-damage-checkpoint	47	1.22e-04	1.98e-03	0.34700	-0.334000	-9.50e-02	7.49e-05	2.60e-01
Signaling-by-cytosolic-FGFR1-fusion-mutants	18	2.90e-02	1.23e-01	0.34700	0.153000	3.11e-01	2.60e-01	2.22e-02
Complex-I-biogenesis	53	2.80e-05	6.16e-04	0.34600	-0.285000	-1.96e-01	3.32e-04	1.35e-02
FGFR1-mutant-receptor-activation	24	1.18e-02	6.34e-02	0.34400	0.060000	3.39e-01	6.11e-01	4.10e-03
Glycogen-storage-diseases	12	1.44e-01	3.45e-01	0.34400	-0.276000	2.05e-01	9.82e-02	2.19e-01
Interleukin-15-signaling	12	1.11e-01	2.97e-01	0.34300	0.049700	3.39e-01	7.66e-01	4.19e-02
GAB1-signalosome	12	1.14e-01	3.00e-01	0.34200	0.043400	3.39e-01	7.95e-01	4.20e-02
Insulin-processing	21	2.36e-02	1.04e-01	0.34200	0.341000	1.61e-02	6.78e-03	8.98e-01
Autodegradation-of-the-E3-ubiquitin-ligase-COP1	47	1.68e-04	2.42e-03	0.34100	-0.327000	-9.60e-02	1.06e-04	2.55e-01
Regulation-of-Apoptosis	49	1.63e-04	2.38e-03	0.34000	-0.339000	-3.08e-02	4.09e-05	7.10e-01
Nucleobase-biosynthesis	15	7.07e-02	2.24e-01	0.34000	-0.339000	-1.77e-02	2.29e-02	9.06e-01
SUMOylation-of-immune-response-proteins	10	1.97e-01	4.11e-01	0.33900	0.317000	-1.18e-01	8.23e-02	5.18e-01
Cell-extracellular-matrix-interactions	16	5.03e-02	1.76e-01	0.33800	-0.297000	-1.61e-01	4.00e-02	2.65e-01
Vpu-mediated-degradation-of-CD4	47	2.72e-04	3.46e-03	0.33600	-0.333000	-4.30e-02	7.85e-05	6.10e-01
Degradation-of-AXIN	51	1.29e-04	1.99e-03	0.33600	-0.331000	-5.49e-02	4.34e-05	4.98e-01
RHO-GTPases-Activate-ROCKs	17	6.69e-02	2.15e-01	0.33600	0.119000	-3.14e-01	3.96e-01	2.51e-02
Amino-acid-transport-across-the-plasma-membrane	20	3.88e-02	1.47e-01	0.33300	0.329000	-5.57e-02	1.10e-02	6.67e-01
Effects-of-PIP2-hydrolysis	20	4.09e-02	1.52e-01	0.33300	0.082600	-3.23e-01	5.23e-01	1.25e-02
Cellular-response-to-hypoxia	66	1.93e-05	4.59e-04	0.33100	-0.331000	5.90e-03	3.42e-06	9.34e-01
Purine-catabolism	16	9.16e-02	2.63e-01	0.33100	0.199000	-2.64e-01	1.68e-01	6.77e-02
Hedgehog-ligand-biogenesis	54	1.28e-04	1.99e-03	0.33000	-0.330000	-1.50e-02	2.78e-05	8.49e-01
Regulation-of-RUNX3-expression-and-activity	51	1.43e-04	2.15e-03	0.32900	-0.313000	-1.04e-01	1.13e-04	2.01e-01
Hyaluronan-metabolism	11	1.98e-01	4.11e-01	0.32900	0.237000	-2.28e-01	1.74e-01	1.91e-01
GRB2-events-in-ERBB2-signaling	12	1.49e-01	3.51e-01	0.32700	0.325000	-3.55e-02	5.12e-02	8.31e-01
Ubiquitin-dependent-degradation-of-Cyclin-D	48	3.04e-04	3.79e-03	0.32600	-0.316000	-8.32e-02	1.57e-04	3.19e-01
SEMA3A-Plexin-repulsion-signaling-by-inhibiting-Integrin-adhesion	11	1.51e-01	3.52e-01	0.32600	-0.122000	-3.02e-01	4.82e-01	8.29e-02
Gluconeogenesis	24	2.02e-02	9.34e-02	0.32600	0.022700	3.25e-01	8.47e-01	5.88e-03
Degradation-of-DVL	52	1.64e-04	2.38e-03	0.32600	-0.316000	-8.02e-02	8.36e-05	3.18e-01
Hh-mutants-abrogate-ligand-secretion	51	2.63e-04	3.38e-03	0.32500	-0.324000	-2.40e-02	6.34e-05	7.67e-01
Hh-mutants-that-don't-undergo-autocatalytic-processing-are-degraded-by-ERAD	51	2.63e-04	3.38e-03	0.32500	-0.324000	-2.40e-02	6.34e-05	7.67e-01
The-role-of-GTSE1-in-G2/M-progression-after-G2-checkpoint	51	1.75e-04	2.49e-03	0.32400	-0.302000	-1.17e-01	1.89e-04	1.47e-01
Transcriptional-activation-of-mitochondrial-biogenesis	49	8.89e-04	9.00e-03	0.32400	-0.263000	1.88e-01	1.44e-03	2.26e-02
Regulation-of-PTEN-stability-and-activity	63	3.35e-05	7.25e-04	0.32400	-0.319000	-5.67e-02	1.23e-05	4.37e-01
Miscellaneous-transport-and-binding-events	16	7.72e-02	2.40e-01	0.32400	0.016600	3.23e-01	9.08e-01	2.52e-02
Downstream-signaling-of-activated-FGFR2	17	8.60e-02	2.55e-01	0.32400	-0.168000	2.77e-01	2.31e-01	4.84e-02
Downstream-signaling-of-activated-FGFR4	17	8.60e-02	2.55e-01	0.32400	-0.168000	2.77e-01	2.31e-01	4.84e-02
Regulation-of-mRNA-stability-by-proteins-that-bind-AU-rich-elements	80	1.62e-06	5.56e-05	0.32200	-0.303000	-1.09e-01	2.79e-06	9.14e-02
GRB2:SOS-provides-linkage-to-MAPK-signaling-for-Integrins	12	1.50e-01	3.51e-01	0.32200	0.322000	1.33e-02	5.38e-02	9.37e-01
ADP-signalling-through-P2Y-purinoceptor-1	17	9.06e-02	2.61e-01	0.32100	0.257000	-1.93e-01	6.66e-02	1.69e-01
Regulation-of-RAS-by-GAPs	62	4.14e-05	8.52e-04	0.31900	-0.302000	-1.03e-01	4.00e-05	1.62e-01
Metabolism-of-fat-soluble-vitamins	24	2.72e-02	1.16e-01	0.31900	0.034200	-3.17e-01	7.72e-01	7.25e-03
Chondroitin-sulfate/dermatan-sulfate-metabolism	40	3.97e-03	2.80e-02	0.31900	0.205000	-2.44e-01	2.52e-02	7.59e-03
Defective-B3GALTL-causes-Peters-plus-syndrome-(PpS)	26	2.41e-02	1.06e-01	0.31800	0.102000	-3.01e-01	3.70e-01	7.94e-03
SCF-beta-TrCP-mediated-degradation-of-Emi1	49	5.67e-04	6.66e-03	0.31700	-0.317000	-1.10e-02	1.27e-04	8.94e-01
TNF-receptor-superfamily-(TNFSF)-members-mediating-non-canonical-NF-kB-pathway	10	2.52e-01	4.84e-01	0.31700	0.177000	-2.63e-01	3.33e-01	1.50e-01
Negative-regulation-of-NOTCH4-signaling	51	2.80e-04	3.52e-03	0.31700	-0.300000	-1.00e-01	2.10e-04	2.15e-01
FOXO-mediated-transcription-of-cell-death-genes	14	1.42e-01	3.41e-01	0.31600	-0.287000	1.31e-01	6.27e-02	3.95e-01
Signal-amplification	22	5.03e-02	1.76e-01	0.31600	0.245000	-1.98e-01	4.64e-02	1.07e-01
Other-semaphorin-interactions	16	7.87e-02	2.43e-01	0.31500	-0.095300	-3.00e-01	5.10e-01	3.76e-02
PI3K-Cascade	25	2.98e-02	1.24e-01	0.31500	-0.108000	2.96e-01	3.50e-01	1.04e-02
Regulation-of-FOXO-transcriptional-activity-by-acetylation	10	2.56e-01	4.85e-01	0.31500	-0.177000	2.60e-01	3.31e-01	1.54e-01
Cargo-concentration-in-the-ER	21	3.78e-02	1.45e-01	0.31500	0.068000	3.07e-01	5.90e-01	1.49e-02
Laminin-interactions	20	3.82e-02	1.45e-01	0.31400	-0.256000	-1.82e-01	4.76e-02	1.59e-01
Interleukin-37-signaling	16	1.11e-01	2.97e-01	0.31300	0.286000	-1.27e-01	4.76e-02	3.78e-01
Mucopolysaccharidoses	11	1.79e-01	3.88e-01	0.31300	0.298000	9.47e-02	8.71e-02	5.87e-01
Signaling-by-FGFR3-in-disease	15	1.36e-01	3.31e-01	0.31300	-0.205000	2.36e-01	1.69e-01	1.14e-01
Signaling-by-FGFR3-point-mutants-in-cancer	15	1.36e-01	3.31e-01	0.31300	-0.205000	2.36e-01	1.69e-01	1.14e-01
Gene-and-protein-expression-by-JAK-STAT-signaling-after-Interleukin-12-stimulation	31	1.52e-02	7.65e-02	0.31200	0.147000	-2.75e-01	1.56e-01	8.01e-03
MAPK6/MAPK4-signaling	76	6.60e-06	1.81e-04	0.31200	-0.287000	-1.21e-01	1.53e-05	6.81e-02
FOXO-mediated-transcription-of-oxidative-stress,-metabolic-and-neuronal-genes	21	3.95e-02	1.48e-01	0.31200	0.076700	3.02e-01	5.43e-01	1.66e-02
Stabilization-of-p53	51	3.64e-04	4.45e-03	0.31100	-0.294000	-1.03e-01	2.89e-04	2.04e-01
Synthesis-of-active-ubiquitin:-roles-of-E1-and-E2-enzymes	26	3.01e-02	1.25e-01	0.31100	-0.138000	2.79e-01	2.23e-01	1.39e-02
Leading-Strand-Synthesis	11	2.03e-01	4.16e-01	0.31100	0.017100	-3.11e-01	9.22e-01	7.45e-02
Polymerase-switching	11	2.03e-01	4.16e-01	0.31100	0.017100	-3.11e-01	9.22e-01	7.45e-02
rRNA-processing	183	3.75e-13	2.89e-11	0.31100	-0.145000	-2.75e-01	7.27e-04	1.63e-10
HSP90-chaperone-cycle-for-steroid-hormone-receptors-(SHR)	33	7.62e-03	4.54e-02	0.31100	-0.310000	-2.20e-02	2.08e-03	8.27e-01
FRS-mediated-FGFR3-signaling	13	1.83e-01	3.93e-01	0.30900	-0.202000	2.35e-01	2.08e-01	1.43e-01
JNK-(c-Jun-kinases)-phosphorylation-and--activation-mediated-by-activated-human-TAK1	17	7.23e-02	2.28e-01	0.30600	0.166000	2.57e-01	2.35e-01	6.69e-02
Oxygen-dependent-proline-hydroxylation-of-Hypoxia-inducible-Factor-Alpha	59	2.48e-04	3.26e-03	0.30600	-0.306000	5.00e-03	4.90e-05	9.47e-01
O-glycosylation-of-TSR-domain-containing-proteins	27	2.82e-02	1.19e-01	0.30500	0.093400	-2.90e-01	4.01e-01	9.11e-03
Erythropoietin-activates-Phosphoinositide-3-kinase-(PI3K)	10	2.65e-01	4.90e-01	0.30500	-0.291000	8.91e-02	1.11e-01	6.26e-01
Cleavage-of-the-damaged-pyrimidine	12	1.70e-01	3.76e-01	0.30400	-0.291000	-8.75e-02	8.08e-02	6.00e-01
Depyrimidination	12	1.70e-01	3.76e-01	0.30400	-0.291000	-8.75e-02	8.08e-02	6.00e-01
Recognition-and-association-of-DNA-glycosylase-with-site-containing-an-affected-pyrimidine	12	1.70e-01	3.76e-01	0.30400	-0.291000	-8.75e-02	8.08e-02	6.00e-01
WNT5A-dependent-internalization-of-FZD4	14	1.35e-01	3.31e-01	0.30400	-0.301000	-3.78e-02	5.09e-02	8.06e-01
Nef-mediates-down-modulation-of-cell-surface-receptors-by-recruiting-them-to-clathrin-adapters	15	1.29e-01	3.26e-01	0.30400	-0.302000	3.32e-02	4.31e-02	8.24e-01
FBXL7-down-regulates-AURKA-during-mitotic-entry-and-in-early-mitosis	50	8.50e-04	8.67e-03	0.30200	-0.300000	-3.77e-02	2.45e-04	6.45e-01
CD209-(DC-SIGN)-signaling	16	9.83e-02	2.74e-01	0.30100	-0.284000	-9.69e-02	4.89e-02	5.02e-01
Glycogen-metabolism	24	5.16e-02	1.78e-01	0.30000	-0.170000	2.47e-01	1.49e-01	3.61e-02
Vitamin-B5-(pantothenate)-metabolism	15	1.10e-01	2.94e-01	0.30000	0.142000	2.64e-01	3.41e-01	7.67e-02
PERK-regulates-gene-expression	28	1.69e-02	8.23e-02	0.30000	-0.120000	-2.75e-01	2.74e-01	1.19e-02
Other-interleukin-signaling	16	1.37e-01	3.33e-01	0.30000	0.146000	-2.62e-01	3.11e-01	7.01e-02
Complement-cascade	22	3.88e-02	1.47e-01	0.29800	-0.180000	-2.38e-01	1.44e-01	5.32e-02
CDT1-association-with-the-CDC6:ORC:origin-complex	52	7.42e-04	7.89e-03	0.29800	-0.295000	-4.71e-02	2.39e-04	5.58e-01
Elastic-fibre-formation	33	1.35e-02	6.93e-02	0.29700	0.295000	-3.12e-02	3.34e-03	7.56e-01
G-beta:gamma-signalling-through-PI3Kgamma	18	1.10e-01	2.94e-01	0.29600	0.124000	-2.69e-01	3.61e-01	4.82e-02
Regulated-proteolysis-of-p75NTR	10	3.03e-01	5.35e-01	0.29400	0.152000	-2.52e-01	4.06e-01	1.68e-01
Keratinization	15	1.65e-01	3.70e-01	0.29400	-0.136000	2.61e-01	3.63e-01	8.04e-02
AKT-phosphorylates-targets-in-the-cytosol	14	1.81e-01	3.91e-01	0.29400	-0.103000	2.75e-01	5.03e-01	7.49e-02
Defective-CFTR-causes-cystic-fibrosis	55	7.16e-04	7.88e-03	0.29300	-0.293000	-2.15e-02	1.77e-04	7.83e-01
Sealing-of-the-nuclear-envelope-(NE)-by-ESCRT-III	21	5.96e-02	1.99e-01	0.29100	-0.071000	-2.82e-01	5.74e-01	2.51e-02
Translation-initiation-complex-formation	50	1.28e-03	1.12e-02	0.29100	-0.062100	-2.84e-01	4.48e-01	5.09e-04
Ribosomal-scanning-and-start-codon-recognition	51	1.22e-03	1.10e-02	0.29100	-0.045800	-2.87e-01	5.72e-01	3.92e-04
Glycerophospholipid-biosynthesis	89	4.63e-06	1.33e-04	0.29000	0.157000	2.44e-01	1.07e-02	7.15e-05
HSF1-activation	24	4.46e-02	1.62e-01	0.28900	-0.287000	-3.40e-02	1.48e-02	7.73e-01
Constitutive-Signaling-by-AKT1-E17K-in-Cancer	25	5.15e-02	1.78e-01	0.28900	-0.096300	2.73e-01	4.05e-01	1.82e-02
alpha-linolenic-(omega3)-and-linoleic-(omega6)-acid-metabolism	10	2.61e-01	4.87e-01	0.28700	0.117000	2.63e-01	5.22e-01	1.51e-01
alpha-linolenic-acid-(ALA)-metabolism	10	2.61e-01	4.87e-01	0.28700	0.117000	2.63e-01	5.22e-01	1.51e-01
Suppression-of-phagosomal-maturation	12	2.24e-01	4.49e-01	0.28700	-0.287000	2.89e-03	8.51e-02	9.86e-01
NOTCH3-Activation-and-Transmission-of-Signal-to-the-Nucleus	24	4.30e-02	1.59e-01	0.28700	-0.080400	-2.75e-01	4.96e-01	1.96e-02
Transcription-of-E2F-targets-under-negative-control-by-DREAM-complex	16	1.22e-01	3.15e-01	0.28600	0.268000	9.86e-02	6.34e-02	4.95e-01
Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S	51	1.48e-03	1.22e-02	0.28500	-0.057800	-2.79e-01	4.75e-01	5.63e-04
N-Glycan-antennae-elongation	12	2.65e-01	4.90e-01	0.28500	0.221000	-1.79e-01	1.84e-01	2.82e-01
Adrenaline,noradrenaline-inhibits-insulin-secretion	19	1.14e-01	3.01e-01	0.28500	0.264000	-1.05e-01	4.62e-02	4.26e-01
Respiratory-electron-transport	97	3.04e-06	9.61e-05	0.28400	-0.256000	-1.23e-01	1.32e-05	3.71e-02
UCH-proteinases	79	5.05e-05	9.89e-04	0.28400	-0.281000	-4.29e-02	1.62e-05	5.10e-01
DNA-strand-elongation	24	6.31e-02	2.07e-01	0.28400	0.083700	-2.71e-01	4.78e-01	2.14e-02
ABC-family-proteins-mediated-transport	85	7.22e-05	1.35e-03	0.28300	-0.263000	1.03e-01	2.77e-05	1.02e-01
Infection-with-Mycobacterium-tuberculosis	24	4.24e-02	1.57e-01	0.28200	-0.184000	-2.14e-01	1.20e-01	7.03e-02
Regulation-of-RUNX2-expression-and-activity	60	8.24e-04	8.54e-03	0.28100	-0.281000	8.20e-03	1.70e-04	9.13e-01
Nucleobase-catabolism	25	6.46e-02	2.10e-01	0.28100	0.251000	-1.25e-01	2.97e-02	2.81e-01
cGMP-effects	11	3.07e-01	5.38e-01	0.28100	0.200000	-1.96e-01	2.50e-01	2.59e-01
Assembly-Of-The-HIV-Virion	13	1.91e-01	4.05e-01	0.28000	-0.257000	-1.11e-01	1.08e-01	4.90e-01
Response-of-EIF2AK1-(HRI)-to-heme-deficiency	15	1.95e-01	4.10e-01	0.27900	0.120000	-2.52e-01	4.21e-01	9.08e-02
Adherens-junctions-interactions	15	2.02e-01	4.15e-01	0.27900	-0.226000	1.65e-01	1.30e-01	2.70e-01
G1/S-Specific-Transcription	18	1.07e-01	2.91e-01	0.27900	0.267000	8.05e-02	5.02e-02	5.54e-01
G-protein-beta:gamma-signalling	23	8.80e-02	2.58e-01	0.27800	0.183000	-2.10e-01	1.28e-01	8.20e-02
Base-Excision-Repair,-AP-Site-Formation	13	1.98e-01	4.11e-01	0.27700	-0.256000	-1.07e-01	1.10e-01	5.05e-01
CRMPs-in-Sema3A-signaling	11	2.48e-01	4.81e-01	0.27700	-0.144000	-2.37e-01	4.07e-01	1.74e-01
Chemokine-receptors-bind-chemokines	12	2.40e-01	4.71e-01	0.27700	-0.275000	-3.44e-02	9.95e-02	8.37e-01
PI3K-events-in-ERBB2-signaling	12	2.20e-01	4.44e-01	0.27600	0.148000	2.33e-01	3.74e-01	1.62e-01
Synthesis-of-PIPs-at-the-Golgi-membrane	15	1.61e-01	3.68e-01	0.27600	0.265000	7.88e-02	7.57e-02	5.97e-01
Downregulation-of-SMAD2/3:SMAD4-transcriptional-activity	21	1.13e-01	3.00e-01	0.27600	-0.169000	2.17e-01	1.79e-01	8.47e-02
Mitochondrial-translation-termination	88	1.59e-05	3.85e-04	0.27600	-0.183000	-2.06e-01	3.12e-03	8.35e-04
p53-Dependent-G1-DNA-Damage-Response	56	1.03e-03	9.73e-03	0.27500	-0.248000	-1.19e-01	1.34e-03	1.25e-01
p53-Dependent-G1/S-DNA-damage-checkpoint	56	1.03e-03	9.73e-03	0.27500	-0.248000	-1.19e-01	1.34e-03	1.25e-01
Carboxyterminal-post-translational-modifications-of-tubulin	20	8.41e-02	2.53e-01	0.27500	-0.133000	-2.40e-01	3.03e-01	6.29e-02
RUNX1-regulates-transcription-of-genes-involved-in-differentiation-of-HSCs	62	4.65e-04	5.52e-03	0.27500	-0.236000	-1.40e-01	1.31e-03	5.67e-02
Assembly-of-the-pre-replicative-complex	59	7.67e-04	8.02e-03	0.27500	-0.255000	-1.01e-01	6.99e-04	1.80e-01
PCP/CE-pathway	80	8.74e-05	1.56e-03	0.27500	-0.272000	-3.98e-02	2.71e-05	5.39e-01
Butyrate-Response-Factor-1-(BRF1)-binds-and-destabilizes-mRNA	16	1.41e-01	3.40e-01	0.27400	-0.125000	-2.44e-01	3.87e-01	9.18e-02
Integrin-cell-surface-interactions	42	1.07e-02	5.90e-02	0.27300	0.058100	-2.67e-01	5.15e-01	2.78e-03
Association-of-TriC/CCT-with-target-proteins-during-biosynthesis	32	3.70e-02	1.43e-01	0.27300	-0.132000	2.39e-01	1.98e-01	1.93e-02
Signaling-by-ROBO-receptors	167	2.20e-09	9.35e-08	0.27300	-0.108000	-2.50e-01	1.61e-02	2.60e-08
Protein-ubiquitination	57	2.29e-03	1.74e-02	0.27200	-0.066600	2.64e-01	3.85e-01	5.68e-04
Insertion-of-tail-anchored-proteins-into-the-endoplasmic-reticulum-membrane	21	1.18e-01	3.09e-01	0.27200	0.148000	-2.28e-01	2.39e-01	7.06e-02
Meiotic-synapsis	20	1.34e-01	3.31e-01	0.27200	0.203000	-1.80e-01	1.16e-01	1.63e-01
Activation-of-IRF3/IRF7-mediated-by-TBK1/IKK-epsilon	12	2.29e-01	4.54e-01	0.27200	-0.201000	-1.82e-01	2.27e-01	2.75e-01
Mitochondrial-translation-elongation	88	2.25e-05	5.14e-04	0.27100	-0.177000	-2.06e-01	4.19e-03	8.74e-04
Removal-of-the-Flap-Intermediate-from-the-C-strand	10	3.66e-01	5.78e-01	0.27100	0.166000	-2.14e-01	3.63e-01	2.41e-01
Mitochondrial-protein-import	56	2.51e-03	1.87e-02	0.27000	-0.267000	4.19e-02	5.50e-04	5.88e-01
Platelet-degranulation	93	1.03e-04	1.74e-03	0.26900	0.158000	-2.18e-01	8.38e-03	2.89e-04
Pink/Parkin-Mediated-Mitophagy	20	1.38e-01	3.35e-01	0.26900	-0.211000	1.67e-01	1.02e-01	1.97e-01
Semaphorin-interactions	51	4.10e-03	2.87e-02	0.26900	0.019100	-2.68e-01	8.14e-01	9.18e-04
Dopamine-Neurotransmitter-Release-Cycle	12	2.58e-01	4.85e-01	0.26900	0.265000	4.35e-02	1.11e-01	7.94e-01
Degradation-of-GLI1-by-the-proteasome	54	2.60e-03	1.93e-02	0.26900	-0.268000	-1.63e-02	6.57e-04	8.36e-01
Mitochondrial-biogenesis	71	9.67e-04	9.47e-03	0.26800	-0.184000	1.96e-01	7.56e-03	4.36e-03
SHC-mediated-cascade:FGFR2	10	3.52e-01	5.66e-01	0.26800	-0.055400	2.62e-01	7.62e-01	1.51e-01
SHC-mediated-cascade:FGFR4	10	3.52e-01	5.66e-01	0.26800	-0.055400	2.62e-01	7.62e-01	1.51e-01
The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport	149	3.11e-07	1.20e-05	0.26800	-0.253000	8.78e-02	1.08e-07	6.50e-02
ABC-transporter-disorders	65	1.19e-03	1.09e-02	0.26700	-0.262000	5.36e-02	2.64e-04	4.56e-01
Autodegradation-of-Cdh1-by-Cdh1:APC/C	60	1.22e-03	1.10e-02	0.26700	-0.262000	-5.24e-02	4.53e-04	4.83e-01
Downstream-signaling-of-activated-FGFR3	18	1.74e-01	3.81e-01	0.26700	-0.163000	2.11e-01	2.32e-01	1.20e-01
GPVI-mediated-activation-cascade	26	5.04e-02	1.76e-01	0.26600	-0.243000	-1.08e-01	3.21e-02	3.39e-01
APC/C:Cdh1-mediated-degradation-of-Cdc20-and-other-APC/C:Cdh1-targeted-proteins-in-late-mitosis/early-G1	62	1.12e-03	1.05e-02	0.26600	-0.263000	-3.77e-02	3.44e-04	6.08e-01
Mitochondrial-translation-initiation	88	3.67e-05	7.81e-04	0.26600	-0.149000	-2.20e-01	1.61e-02	3.65e-04
Signaling-by-PDGFRA-extracellular-domain-mutants	12	2.46e-01	4.78e-01	0.26500	0.173000	2.01e-01	2.98e-01	2.29e-01
Signaling-by-PDGFRA-transmembrane,-juxtamembrane-and-kinase-domain-mutants	12	2.46e-01	4.78e-01	0.26500	0.173000	2.01e-01	2.98e-01	2.29e-01
APC/C:Cdc20-mediated-degradation-of-Securin	61	1.23e-03	1.10e-02	0.26500	-0.261000	-4.85e-02	4.33e-04	5.13e-01
Interleukin-12-signaling	36	3.19e-02	1.30e-01	0.26500	0.179000	-1.95e-01	6.30e-02	4.25e-02
Cytosolic-iron-sulfur-cluster-assembly	10	3.36e-01	5.61e-01	0.26500	-0.033100	-2.63e-01	8.56e-01	1.50e-01
Adenylate-cyclase-inhibitory-pathway	10	3.53e-01	5.67e-01	0.26500	0.263000	-2.38e-02	1.49e-01	8.96e-01
Membrane-binding-and-targetting-of-GAG-proteins	11	2.85e-01	5.13e-01	0.26400	-0.233000	-1.24e-01	1.81e-01	4.77e-01
Synthesis-And-Processing-Of-GAG,-GAGPOL-Polyproteins	11	2.85e-01	5.13e-01	0.26400	-0.233000	-1.24e-01	1.81e-01	4.77e-01
EPHB-mediated-forward-signaling	28	6.03e-02	2.00e-01	0.26300	0.059200	-2.57e-01	5.88e-01	1.88e-02
Antigen-activates-B-Cell-Receptor-(BCR)-leading-to-generation-of-second-messengers	23	7.83e-02	2.42e-01	0.26300	-0.080200	-2.51e-01	5.06e-01	3.76e-02
ATF6-(ATF6-alpha)-activates-chaperone-genes	10	3.49e-01	5.65e-01	0.26300	-0.007050	-2.63e-01	9.69e-01	1.50e-01
Interleukin-6-family-signaling	16	1.59e-01	3.64e-01	0.26300	0.192000	1.80e-01	1.84e-01	2.13e-01
Aggrephagy	18	1.45e-01	3.47e-01	0.26300	-0.260000	-3.62e-02	5.60e-02	7.91e-01
APC:Cdc20-mediated-degradation-of-cell-cycle-proteins-prior-to-satisfation-of-the-cell-cycle-checkpoint	62	1.31e-03	1.13e-02	0.26200	-0.256000	-5.14e-02	4.85e-04	4.85e-01
Cdc20:Phospho-APC/C-mediated-degradation-of-Cyclin-A	62	1.31e-03	1.13e-02	0.26200	-0.256000	-5.14e-02	4.85e-04	4.85e-01
Removal-of-the-Flap-Intermediate	11	3.35e-01	5.61e-01	0.26100	0.048800	-2.56e-01	7.79e-01	1.41e-01
mTOR-signalling	39	2.49e-02	1.08e-01	0.26100	-0.113000	2.35e-01	2.22e-01	1.12e-02
FRS-mediated-FGFR1-signaling	12	3.22e-01	5.52e-01	0.26000	-0.116000	2.33e-01	4.88e-01	1.62e-01
CDK-mediated-phosphorylation-and-removal-of-Cdc6	62	1.46e-03	1.21e-02	0.26000	-0.257000	-4.12e-02	4.72e-04	5.75e-01
Transcription-of-E2F-targets-under-negative-control-by-p107-(RBL1)-and-p130-(RBL2)-in-complex-with-HDAC1	12	2.75e-01	5.03e-01	0.26000	0.250000	7.23e-02	1.35e-01	6.65e-01
Processive-synthesis-on-the-C-strand-of-the-telomere	11	3.61e-01	5.74e-01	0.26000	0.148000	-2.13e-01	3.95e-01	2.20e-01
Striated-Muscle-Contraction	25	8.84e-02	2.58e-01	0.25900	0.059300	-2.52e-01	6.08e-01	2.91e-02
NOD1/2-Signaling-Pathway	28	5.85e-02	1.98e-01	0.25900	0.259000	3.71e-03	1.79e-02	9.73e-01
Phase-0---rapid-depolarisation	24	9.97e-02	2.75e-01	0.25800	-0.065400	2.50e-01	5.79e-01	3.40e-02
Receptor-Mediated-Mitophagy	11	3.20e-01	5.50e-01	0.25800	0.038600	2.55e-01	8.24e-01	1.43e-01
Caspase-activation-via-extrinsic-apoptotic-signalling-pathway	21	1.48e-01	3.48e-01	0.25800	0.211000	-1.48e-01	9.37e-02	2.42e-01
Cobalamin-(Cbl,-vitamin-B12)-transport-and-metabolism	11	3.59e-01	5.72e-01	0.25800	-0.105000	2.35e-01	5.45e-01	1.77e-01
Defects-in-cobalamin-(B12)-metabolism	11	3.59e-01	5.72e-01	0.25800	-0.105000	2.35e-01	5.45e-01	1.77e-01
G1/S-DNA-Damage-Checkpoints	57	2.11e-03	1.63e-02	0.25800	-0.231000	-1.14e-01	2.57e-03	1.37e-01
Translation	265	4.78e-13	3.47e-11	0.25700	-0.135000	-2.19e-01	1.74e-04	9.52e-10
APC/C:Cdc20-mediated-degradation-of-mitotic-proteins	63	1.46e-03	1.21e-02	0.25700	-0.252000	-5.28e-02	5.58e-04	4.70e-01
Activation-of-APC/C-and-APC/C:Cdc20-mediated-degradation-of-mitotic-proteins	63	1.46e-03	1.21e-02	0.25700	-0.252000	-5.28e-02	5.58e-04	4.70e-01
Sema4D-induced-cell-migration-and-growth-cone-collapse	18	1.75e-01	3.82e-01	0.25700	0.038500	-2.54e-01	7.77e-01	6.23e-02
RIPK1-mediated-regulated-necrosis	13	3.06e-01	5.37e-01	0.25700	0.124000	-2.25e-01	4.41e-01	1.61e-01
Regulated-Necrosis	13	3.06e-01	5.37e-01	0.25700	0.124000	-2.25e-01	4.41e-01	1.61e-01
N-glycan-antennae-elongation-in-the-medial/trans-Golgi	18	1.94e-01	4.08e-01	0.25600	0.229000	-1.15e-01	9.28e-02	4.00e-01
Regulation-of-Complement-cascade	19	1.32e-01	3.31e-01	0.25600	-0.107000	-2.32e-01	4.19e-01	7.99e-02
Processive-synthesis-on-the-lagging-strand	12	3.17e-01	5.48e-01	0.25600	0.042100	-2.52e-01	8.01e-01	1.30e-01
Activation-of-Matrix-Metalloproteinases	12	3.43e-01	5.64e-01	0.25500	0.153000	-2.05e-01	3.60e-01	2.19e-01
ER-Phagosome-pathway	69	6.65e-04	7.40e-03	0.25500	-0.225000	-1.19e-01	1.22e-03	8.75e-02
Meiotic-recombination	15	2.37e-01	4.68e-01	0.25500	0.253000	-2.90e-02	8.98e-02	8.46e-01
Cell-surface-interactions-at-the-vascular-wall	77	1.02e-03	9.73e-03	0.25400	0.114000	-2.27e-01	8.31e-02	5.85e-04
Mitochondrial-calcium-ion-transport	20	1.65e-01	3.70e-01	0.25300	-0.233000	1.00e-01	7.18e-02	4.37e-01
Degradation-of-GLI2-by-the-proteasome	55	5.04e-03	3.36e-02	0.25300	-0.253000	5.37e-03	1.18e-03	9.45e-01
Meiosis	35	4.47e-02	1.62e-01	0.25300	0.225000	-1.16e-01	2.14e-02	2.37e-01
Interaction-between-L1-and-Ankyrins	15	2.39e-01	4.71e-01	0.25300	-0.016300	2.52e-01	9.13e-01	9.11e-02
Response-to-elevated-platelet-cytosolic-Ca2+	97	2.34e-04	3.14e-03	0.25200	0.148000	-2.03e-01	1.17e-02	5.53e-04
SCF(Skp2)-mediated-degradation-of-p27/p21	51	5.47e-03	3.61e-02	0.25200	-0.233000	-9.41e-02	3.98e-03	2.46e-01
Trafficking-of-GluR2-containing-AMPA-receptors	11	3.56e-01	5.70e-01	0.25100	-0.250000	2.36e-02	1.51e-01	8.92e-01
Signaling-by-Hippo	18	1.59e-01	3.64e-01	0.25100	0.231000	9.87e-02	9.00e-02	4.69e-01
NIK-->noncanonical-NF-kB-signaling	55	5.50e-03	3.61e-02	0.25100	-0.251000	6.65e-03	1.30e-03	9.32e-01
GLI3-is-processed-to-GLI3R-by-the-proteasome	55	5.91e-03	3.70e-02	0.25100	-0.250000	1.88e-02	1.36e-03	8.10e-01
Mitochondrial-translation	94	5.81e-05	1.12e-03	0.25000	-0.169000	-1.85e-01	4.68e-03	1.99e-03
Regulation-of-PTEN-mRNA-translation	11	3.97e-01	6.04e-01	0.24800	-0.187000	1.63e-01	2.83e-01	3.49e-01
Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.	103	4.30e-05	8.70e-04	0.24700	-0.230000	-8.90e-02	5.63e-05	1.19e-01
Response-of-Mtb-to-phagocytosis	21	1.23e-01	3.17e-01	0.24500	-0.192000	-1.52e-01	1.28e-01	2.27e-01
Cardiac-conduction	78	6.30e-04	7.11e-03	0.24500	0.057100	2.38e-01	3.84e-01	2.79e-04
G-alpha-(z)-signalling-events	30	8.76e-02	2.57e-01	0.24400	0.176000	-1.70e-01	9.62e-02	1.08e-01
FGFR2-alternative-splicing	24	1.14e-01	3.01e-01	0.24400	-0.007680	-2.44e-01	9.48e-01	3.89e-02
Uptake-and-actions-of-bacterial-toxins	22	1.68e-01	3.74e-01	0.24300	-0.144000	1.96e-01	2.43e-01	1.11e-01
Regulation-of-innate-immune-responses-to-cytosolic-DNA	11	3.38e-01	5.63e-01	0.24300	-0.168000	-1.76e-01	3.36e-01	3.11e-01
Asymmetric-localization-of-PCP-proteins	58	5.53e-03	3.61e-02	0.24300	-0.243000	-8.38e-03	1.40e-03	9.12e-01
Dectin-1-mediated-noncanonical-NF-kB-signaling	56	6.80e-03	4.13e-02	0.24300	-0.242000	-5.35e-03	1.71e-03	9.45e-01
Metabolism-of-porphyrins	18	1.93e-01	4.08e-01	0.24200	-0.240000	-3.20e-02	7.76e-02	8.14e-01
Regulation-of-IFNA-signaling	11	3.44e-01	5.64e-01	0.24200	-0.147000	-1.92e-01	3.99e-01	2.70e-01
Downstream-TCR-signaling	76	1.50e-03	1.23e-02	0.24100	-0.240000	2.81e-02	3.12e-04	6.72e-01
AMER1-mutants-destabilize-the-destruction-complex	14	2.59e-01	4.85e-01	0.24100	0.158000	1.82e-01	3.07e-01	2.38e-01
APC-truncation-mutants-have-impaired-AXIN-binding	14	2.59e-01	4.85e-01	0.24100	0.158000	1.82e-01	3.07e-01	2.38e-01
AXIN-missense-mutants-destabilize-the-destruction-complex	14	2.59e-01	4.85e-01	0.24100	0.158000	1.82e-01	3.07e-01	2.38e-01
AXIN-mutants-destabilize-the-destruction-complex,-activating-WNT-signaling	14	2.59e-01	4.85e-01	0.24100	0.158000	1.82e-01	3.07e-01	2.38e-01
Truncations-of-AMER1-destabilize-the-destruction-complex	14	2.59e-01	4.85e-01	0.24100	0.158000	1.82e-01	3.07e-01	2.38e-01
truncated-APC-mutants-destabilize-the-destruction-complex	14	2.59e-01	4.85e-01	0.24100	0.158000	1.82e-01	3.07e-01	2.38e-01
Synthesis-of-very-long-chain-fatty-acyl-CoAs	15	2.79e-01	5.08e-01	0.24100	0.238000	-3.75e-02	1.11e-01	8.02e-01
Sema4D-in-semaphorin-signaling	21	1.88e-01	4.01e-01	0.24100	0.130000	-2.03e-01	3.04e-01	1.08e-01
Glutamate-Neurotransmitter-Release-Cycle	12	3.70e-01	5.82e-01	0.24100	0.230000	-6.95e-02	1.67e-01	6.77e-01
Telomere-Extension-By-Telomerase	14	2.60e-01	4.87e-01	0.24000	-0.171000	-1.69e-01	2.68e-01	2.74e-01
NR1H3-&-NR1H2-regulate-gene-expression-linked-to-cholesterol-transport-and-efflux	30	9.50e-02	2.67e-01	0.24000	-0.160000	1.79e-01	1.29e-01	9.04e-02
G0-and-Early-G1	18	1.91e-01	4.05e-01	0.23900	0.222000	8.79e-02	1.03e-01	5.19e-01
Downstream-signaling-events-of-B-Cell-Receptor-(BCR)	73	1.53e-03	1.24e-02	0.23800	-0.234000	-4.50e-02	5.50e-04	5.07e-01
Myogenesis	22	1.59e-01	3.64e-01	0.23800	-0.030600	2.36e-01	8.04e-01	5.52e-02
Activation-of-NF-kappaB-in-B-cells	60	5.82e-03	3.69e-02	0.23800	-0.238000	-6.45e-03	1.46e-03	9.31e-01
Bile-acid-and-bile-salt-metabolism	20	1.88e-01	4.01e-01	0.23800	-0.029700	2.36e-01	8.18e-01	6.78e-02
Signaling-by-FGFR1-in-disease	31	6.90e-02	2.20e-01	0.23800	0.010700	2.38e-01	9.18e-01	2.21e-02
Regulation-of-gene-expression-in-late-stage-(branching-morphogenesis)-pancreatic-bud-precursor-cells	12	3.96e-01	6.03e-01	0.23800	-0.142000	1.90e-01	3.95e-01	2.53e-01
RNA-Polymerase-I-Transcription-Termination	30	6.09e-02	2.01e-01	0.23700	-0.164000	-1.70e-01	1.19e-01	1.06e-01
mRNA-decay-by-5'-to-3'-exoribonuclease	15	2.55e-01	4.85e-01	0.23700	-0.214000	-9.98e-02	1.51e-01	5.03e-01
PIWI-interacting-RNA-(piRNA)-biogenesis	15	2.49e-01	4.81e-01	0.23600	-0.141000	-1.90e-01	3.44e-01	2.03e-01
Regulation-of-necroptotic-cell-death	11	4.29e-01	6.30e-01	0.23600	0.201000	-1.25e-01	2.49e-01	4.73e-01
FCERI-mediated-NF-kB-activation	70	2.73e-03	2.01e-02	0.23600	-0.236000	-6.66e-03	6.54e-04	9.23e-01
COPI-independent-Golgi-to-ER-retrograde-traffic	30	7.29e-02	2.30e-01	0.23600	0.046500	2.31e-01	6.59e-01	2.85e-02
Olfactory-Signaling-Pathway	10	4.28e-01	6.30e-01	0.23500	-0.021000	-2.34e-01	9.08e-01	2.01e-01
Glycogen-synthesis	13	3.63e-01	5.75e-01	0.23400	-0.222000	7.63e-02	1.67e-01	6.34e-01
Regulation-of-MECP2-expression-and-activity	26	1.29e-01	3.26e-01	0.23400	-0.056900	2.27e-01	6.16e-01	4.52e-02
DNA-Replication-Pre-Initiation	68	2.43e-03	1.83e-02	0.23400	-0.213000	-9.58e-02	2.38e-03	1.73e-01
Circadian-Clock	63	5.93e-03	3.70e-02	0.23400	-0.012300	2.33e-01	8.66e-01	1.38e-03
Tristetraprolin-(TTP,-ZFP36)-binds-and-destabilizes-mRNA	16	2.53e-01	4.85e-01	0.23400	-0.048000	-2.29e-01	7.40e-01	1.14e-01
Resolution-of-D-loop-Structures-through-Synthesis-Dependent-Strand-Annealing-(SDSA)	13	3.50e-01	5.65e-01	0.23300	0.232000	-2.56e-02	1.48e-01	8.73e-01
Fanconi-Anemia-Pathway	27	9.92e-02	2.75e-01	0.23300	-0.229000	-4.60e-02	3.96e-02	6.79e-01
Energy-dependent-regulation-of-mTOR-by-LKB1-AMPK	28	1.20e-01	3.12e-01	0.23300	-0.102000	2.09e-01	3.50e-01	5.52e-02
Fatty-acid-metabolism	118	3.89e-05	8.14e-04	0.23300	0.072900	2.21e-01	1.72e-01	3.52e-05
Mitophagy	27	1.37e-01	3.34e-01	0.23200	-0.162000	1.67e-01	1.46e-01	1.34e-01
Nuclear-Receptor-transcription-pathway	38	5.63e-02	1.91e-01	0.23200	-0.090400	2.14e-01	3.35e-01	2.25e-02
Beta-catenin-phosphorylation-cascade	16	2.51e-01	4.83e-01	0.23200	0.069900	2.22e-01	6.28e-01	1.25e-01
Orc1-removal-from-chromatin	61	4.84e-03	3.28e-02	0.23200	-0.212000	-9.42e-02	4.17e-03	2.04e-01
IRS-mediated-signalling	29	1.11e-01	2.97e-01	0.23200	-0.086600	2.15e-01	4.20e-01	4.47e-02
Synthesis-of-bile-acids-and-bile-salts	19	2.27e-01	4.53e-01	0.23200	-0.050200	2.26e-01	7.05e-01	8.76e-02
Reproduction	40	5.28e-02	1.82e-01	0.23000	0.208000	-9.67e-02	2.28e-02	2.90e-01
Signaling-by-ERBB2-TMD/JMD-mutants	18	2.61e-01	4.87e-01	0.22900	0.216000	-7.64e-02	1.12e-01	5.75e-01
Extracellular-matrix-organization	185	4.40e-07	1.64e-05	0.22900	-0.015700	-2.28e-01	7.14e-01	9.58e-08
E3-ubiquitin-ligases-ubiquitinate-target-proteins	40	4.90e-02	1.73e-01	0.22800	-0.047800	2.23e-01	6.01e-01	1.47e-02
TCR-signaling	88	1.05e-03	9.90e-03	0.22800	-0.228000	4.68e-03	2.23e-04	9.40e-01
PKMTs-methylate-histone-lysines	40	5.92e-02	1.98e-01	0.22800	-0.165000	1.57e-01	7.11e-02	8.53e-02
RNA-Polymerase-III-Transcription-Termination	23	1.56e-01	3.62e-01	0.22700	-0.224000	-3.83e-02	6.30e-02	7.50e-01
Interleukin-12-family-signaling	41	5.64e-02	1.91e-01	0.22700	0.165000	-1.56e-01	6.76e-02	8.41e-02
Chaperone-Mediated-Autophagy	16	2.66e-01	4.90e-01	0.22600	-0.209000	-8.69e-02	1.49e-01	5.47e-01
Glutathione-conjugation	24	1.34e-01	3.31e-01	0.22500	0.116000	1.93e-01	3.26e-01	1.01e-01
Signaling-by-NOTCH4	78	1.62e-03	1.29e-02	0.22500	-0.204000	-9.52e-02	1.83e-03	1.47e-01
Polymerase-switching-on-the-C-strand-of-the-telomere	12	3.85e-01	5.95e-01	0.22500	-0.041200	-2.21e-01	8.05e-01	1.84e-01
Regulation-of-APC/C-activators-between-G1/S-and-early-anaphase	67	5.80e-03	3.69e-02	0.22500	-0.225000	-6.61e-03	1.46e-03	9.26e-01
Signaling-by-Retinoic-Acid	31	8.50e-02	2.53e-01	0.22500	0.044500	2.21e-01	6.68e-01	3.36e-02
Processing-of-SMDT1	14	3.62e-01	5.75e-01	0.22500	-0.217000	6.11e-02	1.61e-01	6.92e-01
Listeria-monocytogenes-entry-into-host-cells	14	3.63e-01	5.75e-01	0.22500	-0.216000	6.41e-02	1.63e-01	6.78e-01
VxPx-cargo-targeting-to-cilium	16	3.26e-01	5.55e-01	0.22400	-0.090200	2.05e-01	5.32e-01	1.57e-01
Abortive-elongation-of-HIV-1-transcript-in-the-absence-of-Tat	23	1.57e-01	3.62e-01	0.22300	-0.087500	-2.05e-01	4.68e-01	8.87e-02
Mitochondrial-iron-sulfur-cluster-biogenesis	12	3.77e-01	5.89e-01	0.22300	-0.101000	-1.99e-01	5.46e-01	2.33e-01
Cytochrome-c-mediated-apoptotic-response	11	4.28e-01	6.30e-01	0.22200	0.220000	3.57e-02	2.08e-01	8.37e-01
B-WICH-complex-positively-regulates-rRNA-expression	31	8.52e-02	2.53e-01	0.22200	-0.208000	-7.72e-02	4.48e-02	4.57e-01
Selective-autophagy	56	2.42e-02	1.06e-01	0.22100	-0.173000	1.37e-01	2.53e-02	7.57e-02
Plasma-lipoprotein-remodeling	13	3.96e-01	6.03e-01	0.22000	-0.218000	3.30e-02	1.74e-01	8.37e-01
NR1H2-and-NR1H3-mediated-signaling	35	8.43e-02	2.53e-01	0.22000	-0.039500	2.17e-01	6.86e-01	2.67e-02
Signaling-by-the-B-Cell-Receptor-(BCR)	95	6.05e-04	6.98e-03	0.22000	-0.203000	-8.59e-02	6.60e-04	1.48e-01
Phospholipid-metabolism	162	2.73e-06	8.88e-05	0.22000	0.125000	1.81e-01	6.39e-03	7.23e-05
Transcriptional-regulation-by-RUNX3	87	1.59e-03	1.28e-02	0.21900	-0.218000	-2.46e-02	4.46e-04	6.92e-01
VEGFR2-mediated-vascular-permeability	24	1.75e-01	3.82e-01	0.21900	-0.219000	1.43e-03	6.30e-02	9.90e-01
Synthesis-of-bile-acids-and-bile-salts-via-7alpha-hydroxycholesterol	11	4.72e-01	6.63e-01	0.21900	-0.071600	2.07e-01	6.81e-01	2.34e-01
Defective-EXT1-causes-exostoses-1,-TRPS2-and-CHDS	12	4.02e-01	6.06e-01	0.21900	-0.055200	-2.12e-01	7.41e-01	2.04e-01
Defective-EXT2-causes-exostoses-2	12	4.02e-01	6.06e-01	0.21900	-0.055200	-2.12e-01	7.41e-01	2.04e-01
MicroRNA-(miRNA)-biogenesis	24	1.51e-01	3.52e-01	0.21900	-0.183000	-1.19e-01	1.21e-01	3.12e-01
G-protein-mediated-events	43	3.32e-02	1.33e-01	0.21800	0.166000	1.42e-01	6.01e-02	1.07e-01
PLC-beta-mediated-events	43	3.32e-02	1.33e-01	0.21800	0.166000	1.42e-01	6.01e-02	1.07e-01
Peptide-ligand-binding-receptors	36	6.48e-02	2.10e-01	0.21800	-0.064200	-2.09e-01	5.06e-01	3.04e-02
Methylation	11	4.40e-01	6.40e-01	0.21800	0.045200	2.13e-01	7.95e-01	2.21e-01
MAPK-targets/-Nuclear-events-mediated-by-MAP-kinases	30	1.29e-01	3.26e-01	0.21700	-0.047300	2.12e-01	6.54e-01	4.44e-02
Signaling-by-NOTCH2	27	1.23e-01	3.17e-01	0.21600	-0.176000	-1.26e-01	1.14e-01	2.57e-01
Regulation-of-IFNG-signaling	12	4.09e-01	6.12e-01	0.21600	0.061100	2.07e-01	7.14e-01	2.14e-01
RUNX1-regulates-genes-involved-in-megakaryocyte-differentiation-and-platelet-function	34	9.94e-02	2.75e-01	0.21600	-0.212000	3.92e-02	3.23e-02	6.92e-01
p38MAPK-events	12	4.62e-01	6.57e-01	0.21600	0.109000	-1.86e-01	5.14e-01	2.64e-01
Triglyceride-catabolism	14	3.64e-01	5.76e-01	0.21600	0.214000	2.70e-02	1.66e-01	8.61e-01
Protein-localization	141	1.46e-04	2.17e-03	0.21500	-0.146000	1.58e-01	2.84e-03	1.19e-03
Ras-activation-upon-Ca2+-influx-through-NMDA-receptor	13	4.20e-01	6.24e-01	0.21500	-0.208000	5.43e-02	1.93e-01	7.35e-01
Negative-regulation-of-FGFR2-signaling	20	2.72e-01	4.99e-01	0.21500	-0.085900	1.98e-01	5.06e-01	1.26e-01
Negative-regulation-of-FGFR4-signaling	20	2.72e-01	4.99e-01	0.21500	-0.085900	1.98e-01	5.06e-01	1.26e-01
Pre-NOTCH-Transcription-and-Translation	31	1.05e-01	2.86e-01	0.21500	-0.210000	-4.53e-02	4.29e-02	6.62e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-Cytochrome-C-Release	13	4.42e-01	6.41e-01	0.21500	0.165000	-1.37e-01	3.02e-01	3.93e-01
Platelet-activation,-signaling-and-aggregation	187	8.29e-06	2.18e-04	0.21400	0.098400	-1.90e-01	2.08e-02	8.26e-06
Lagging-Strand-Synthesis	16	3.50e-01	5.65e-01	0.21300	0.047700	-2.08e-01	7.41e-01	1.51e-01
Signalling-to-RAS	17	3.44e-01	5.64e-01	0.21300	0.185000	-1.06e-01	1.88e-01	4.49e-01
Cyclin-A/B1/B2-associated-events-during-G2/M-transition	17	2.94e-01	5.23e-01	0.21300	-0.055500	-2.06e-01	6.92e-01	1.42e-01
MAP-kinase-activation	60	1.72e-02	8.28e-02	0.21300	-0.006660	2.12e-01	9.29e-01	4.47e-03
Assembly-and-cell-surface-presentation-of-NMDA-receptors	14	4.23e-01	6.26e-01	0.21200	-0.140000	1.60e-01	3.65e-01	3.00e-01
mTORC1-mediated-signalling	22	2.48e-01	4.81e-01	0.21200	-0.081800	1.96e-01	5.07e-01	1.12e-01
Non-integrin-membrane-ECM-interactions	36	6.80e-02	2.17e-01	0.21200	-0.167000	-1.31e-01	8.26e-02	1.75e-01
HCMV-Early-Events	54	3.54e-02	1.39e-01	0.21200	-0.111000	1.81e-01	1.58e-01	2.17e-02
Diseases-associated-with-glycosylation-precursor-biosynthesis	17	3.46e-01	5.65e-01	0.21200	0.094500	-1.89e-01	5.00e-01	1.77e-01
Deactivation-of-the-beta-catenin-transactivating-complex	33	8.73e-02	2.57e-01	0.21100	-0.166000	-1.31e-01	9.93e-02	1.94e-01
p130Cas-linkage-to-MAPK-signaling-for-integrins	12	4.76e-01	6.67e-01	0.21100	0.187000	-9.83e-02	2.63e-01	5.56e-01
activated-TAK1-mediates-p38-MAPK-activation	18	2.88e-01	5.16e-01	0.21100	0.028800	2.09e-01	8.32e-01	1.25e-01
COPI-dependent-Golgi-to-ER-retrograde-traffic	58	2.02e-02	9.34e-02	0.21100	0.211000	2.43e-03	5.50e-03	9.75e-01
Tight-junction-interactions	10	5.40e-01	7.17e-01	0.21100	0.105000	-1.83e-01	5.66e-01	3.16e-01
Potassium-Channels	40	5.34e-02	1.83e-01	0.21100	0.123000	1.71e-01	1.78e-01	6.19e-02
HS-GAG-degradation	17	3.41e-01	5.64e-01	0.21000	0.052300	-2.03e-01	7.09e-01	1.47e-01
Cell-junction-organization	49	3.18e-02	1.30e-01	0.21000	-0.197000	-7.01e-02	1.69e-02	3.96e-01
Nicotinamide-salvaging	13	4.04e-01	6.07e-01	0.20900	-0.201000	-5.79e-02	2.10e-01	7.18e-01
Synthesis,-secretion,-and-deacylation-of-Ghrelin	11	5.23e-01	7.05e-01	0.20800	0.133000	-1.60e-01	4.45e-01	3.59e-01
Synthesis-of-IP3-and-IP4-in-the-cytosol	21	2.91e-01	5.21e-01	0.20800	0.150000	-1.44e-01	2.34e-01	2.55e-01
Regulation-of-signaling-by-CBL	16	3.81e-01	5.90e-01	0.20700	-0.191000	8.09e-02	1.87e-01	5.75e-01
RNA-Polymerase-III-Chain-Elongation	18	2.77e-01	5.04e-01	0.20700	-0.138000	-1.54e-01	3.10e-01	2.57e-01
Growth-hormone-receptor-signaling	18	3.48e-01	5.65e-01	0.20700	-0.127000	1.63e-01	3.49e-01	2.31e-01
Cohesin-Loading-onto-Chromatin	10	4.91e-01	6.83e-01	0.20700	0.151000	1.41e-01	4.09e-01	4.40e-01
Mitotic-Telophase/Cytokinesis	10	4.91e-01	6.83e-01	0.20700	0.151000	1.41e-01	4.09e-01	4.40e-01
Antigen-processing-Cross-presentation	80	3.85e-03	2.73e-02	0.20600	-0.182000	-9.68e-02	4.86e-03	1.35e-01
Diseases-associated-with-O-glycosylation-of-proteins	39	9.33e-02	2.65e-01	0.20600	0.059500	-1.98e-01	5.21e-01	3.27e-02
Transcriptional-regulation-of-pluripotent-stem-cells	14	4.04e-01	6.07e-01	0.20600	0.006220	2.06e-01	9.68e-01	1.82e-01
Class-A/1-(Rhodopsin-like-receptors)	62	1.29e-02	6.73e-02	0.20600	-0.154000	-1.36e-01	3.57e-02	6.41e-02
RUNX3-regulates-NOTCH-signaling	13	4.69e-01	6.61e-01	0.20600	-0.174000	1.10e-01	2.78e-01	4.93e-01
SUMOylation-of-intracellular-receptors	22	2.63e-01	4.89e-01	0.20600	-0.054900	1.98e-01	6.56e-01	1.08e-01
Opioid-Signalling	70	8.88e-03	5.12e-02	0.20500	0.194000	6.68e-02	5.00e-03	3.35e-01
APC/C-mediated-degradation-of-cell-cycle-proteins	69	1.14e-02	6.20e-02	0.20500	-0.204000	-2.05e-02	3.36e-03	7.69e-01
Regulation-of-mitotic-cell-cycle	69	1.14e-02	6.20e-02	0.20500	-0.204000	-2.05e-02	3.36e-03	7.69e-01
FGFR2-mutant-receptor-activation	20	2.59e-01	4.85e-01	0.20500	-0.193000	-6.83e-02	1.34e-01	5.97e-01
Deposition-of-new-CENPA-containing-nucleosomes-at-the-centromere	13	4.08e-01	6.11e-01	0.20400	0.144000	1.44e-01	3.70e-01	3.68e-01
Nucleosome-assembly	13	4.08e-01	6.11e-01	0.20400	0.144000	1.44e-01	3.70e-01	3.68e-01
Competing-endogenous-RNAs-(ceRNAs)-regulate-PTEN-translation	10	5.67e-01	7.31e-01	0.20400	-0.123000	1.62e-01	5.00e-01	3.75e-01
Synthesis-of-IP2,-IP,-and-Ins-in-the-cytosol	12	4.77e-01	6.68e-01	0.20400	-0.017300	2.03e-01	9.17e-01	2.24e-01
RAF-independent-MAPK1/3-activation	18	3.48e-01	5.65e-01	0.20300	-0.193000	6.28e-02	1.56e-01	6.45e-01
TNFR2-non-canonical-NF-kB-pathway	68	1.16e-02	6.29e-02	0.20300	-0.194000	-5.94e-02	5.71e-03	3.98e-01
Disorders-of-developmental-biology	10	5.70e-01	7.31e-01	0.20300	-0.120000	1.64e-01	5.12e-01	3.71e-01
Loss-of-function-of-MECP2-in-Rett-syndrome	10	5.70e-01	7.31e-01	0.20300	-0.120000	1.64e-01	5.12e-01	3.71e-01
Pervasive-developmental-disorders	10	5.70e-01	7.31e-01	0.20300	-0.120000	1.64e-01	5.12e-01	3.71e-01
RNA-Polymerase-I-Promoter-Escape	30	1.31e-01	3.28e-01	0.20300	-0.166000	-1.16e-01	1.15e-01	2.73e-01
Interleukin-20-family-signaling	13	4.45e-01	6.44e-01	0.20300	0.004730	2.02e-01	9.76e-01	2.06e-01
VEGFR2-mediated-cell-proliferation	17	3.42e-01	5.64e-01	0.20200	-0.019600	-2.02e-01	8.89e-01	1.50e-01
Processing-of-Capped-Intronless-Pre-mRNA	24	1.97e-01	4.11e-01	0.20200	-0.148000	-1.37e-01	2.10e-01	2.45e-01
Host-Interactions-of-HIV-factors	111	1.02e-03	9.73e-03	0.20100	-0.201000	-1.91e-02	2.69e-04	7.29e-01
tRNA-modification-in-the-nucleus-and-cytosol	39	8.40e-02	2.53e-01	0.20100	-0.196000	-4.48e-02	3.46e-02	6.29e-01
Polo-like-kinase-mediated-events	10	5.73e-01	7.34e-01	0.20000	-0.088600	1.79e-01	6.28e-01	3.27e-01
Nucleotide-binding-domain,-leucine-rich-repeat-containing-receptor-(NLR)-signaling-pathways	40	9.43e-02	2.67e-01	0.20000	0.199000	-2.04e-02	2.98e-02	8.24e-01
Signaling-by-FGFR2-IIIa-TM	18	3.06e-01	5.38e-01	0.19900	-0.125000	-1.54e-01	3.57e-01	2.57e-01
Misspliced-GSK3beta-mutants-stabilize-beta-catenin	15	3.80e-01	5.89e-01	0.19900	0.085200	1.80e-01	5.68e-01	2.28e-01
S33-mutants-of-beta-catenin-aren't-phosphorylated	15	3.80e-01	5.89e-01	0.19900	0.085200	1.80e-01	5.68e-01	2.28e-01
S37-mutants-of-beta-catenin-aren't-phosphorylated	15	3.80e-01	5.89e-01	0.19900	0.085200	1.80e-01	5.68e-01	2.28e-01
S45-mutants-of-beta-catenin-aren't-phosphorylated	15	3.80e-01	5.89e-01	0.19900	0.085200	1.80e-01	5.68e-01	2.28e-01
T41-mutants-of-beta-catenin-aren't-phosphorylated	15	3.80e-01	5.89e-01	0.19900	0.085200	1.80e-01	5.68e-01	2.28e-01
phosphorylation-site-mutants-of-CTNNB1-are-not-targeted-to-the-proteasome-by-the-destruction-complex	15	3.80e-01	5.89e-01	0.19900	0.085200	1.80e-01	5.68e-01	2.28e-01
Neddylation	201	2.12e-05	4.94e-04	0.19900	-0.109000	1.66e-01	7.92e-03	5.13e-05
HCMV-Infection	75	1.82e-02	8.66e-02	0.19800	-0.115000	1.61e-01	8.57e-02	1.60e-02
Axon-guidance	394	2.19e-11	1.08e-09	0.19800	-0.100000	-1.70e-01	7.02e-04	8.43e-09
Triglyceride-metabolism	22	2.40e-01	4.71e-01	0.19800	0.151000	1.27e-01	2.19e-01	3.02e-01
ISG15-antiviral-mechanism	61	3.35e-02	1.33e-01	0.19700	-0.191000	5.09e-02	1.01e-02	4.93e-01
The-role-of-Nef-in-HIV-1-replication-and-disease-pathogenesis	21	2.82e-01	5.09e-01	0.19700	-0.195000	-2.65e-02	1.21e-01	8.33e-01
Antiviral-mechanism-by-IFN-stimulated-genes	66	2.32e-02	1.03e-01	0.19700	-0.195000	2.56e-02	6.10e-03	7.19e-01
Antigen-processing:-Ubiquitination-&-Proteasome-degradation	262	8.11e-07	2.86e-05	0.19700	-0.074800	1.82e-01	3.80e-02	4.29e-07
RUNX2-regulates-osteoblast-differentiation	19	3.25e-01	5.54e-01	0.19700	0.197000	7.92e-03	1.38e-01	9.52e-01
Interleukin-17-signaling	62	2.63e-02	1.13e-01	0.19700	0.003940	1.97e-01	9.57e-01	7.39e-03
Degradation-of-the-extracellular-matrix	54	3.57e-02	1.40e-01	0.19600	-0.064800	-1.85e-01	4.10e-01	1.87e-02
Glutamate-binding,-activation-of-AMPA-receptors-and-synaptic-plasticity	20	3.43e-01	5.64e-01	0.19600	-0.177000	8.42e-02	1.71e-01	5.15e-01
Trafficking-of-AMPA-receptors	20	3.43e-01	5.64e-01	0.19600	-0.177000	8.42e-02	1.71e-01	5.15e-01
PI3K/AKT-Signaling-in-Cancer	66	3.29e-02	1.33e-01	0.19500	-0.143000	1.33e-01	4.44e-02	6.26e-02
Peptide-hormone-metabolism	48	7.41e-02	2.32e-01	0.19500	0.187000	-5.52e-02	2.52e-02	5.08e-01
Rap1-signalling	13	4.64e-01	6.58e-01	0.19500	-0.193000	-2.87e-02	2.29e-01	8.58e-01
Insulin-receptor-signalling-cascade	34	1.61e-01	3.69e-01	0.19500	-0.065600	1.83e-01	5.08e-01	6.45e-02
TP53-regulates-transcription-of-additional-cell-cycle-genes-whose-exact-role-in-the-p53-pathway-remain-uncertain	18	3.94e-01	6.01e-01	0.19500	0.118000	-1.55e-01	3.88e-01	2.55e-01
InlB-mediated-entry-of-Listeria-monocytogenes-into-host-cell	11	5.48e-01	7.23e-01	0.19400	-0.190000	4.13e-02	2.76e-01	8.13e-01
Formation-of-the-Early-Elongation-Complex	33	1.46e-01	3.47e-01	0.19300	-0.040800	-1.88e-01	6.85e-01	6.14e-02
Formation-of-the-HIV-1-Early-Elongation-Complex	33	1.46e-01	3.47e-01	0.19300	-0.040800	-1.88e-01	6.85e-01	6.14e-02
Cytosolic-sulfonation-of-small-molecules	12	5.12e-01	6.98e-01	0.19200	0.002390	-1.92e-01	9.89e-01	2.49e-01
Estrogen-dependent-nuclear-events-downstream-of-ESR-membrane-signaling	19	3.84e-01	5.94e-01	0.19200	-0.129000	1.43e-01	3.31e-01	2.82e-01
Neurotransmitter-release-cycle	23	2.52e-01	4.84e-01	0.19200	0.174000	8.05e-02	1.48e-01	5.04e-01
Formation-of-Fibrin-Clot-(Clotting-Cascade)	14	4.55e-01	6.51e-01	0.19200	0.191000	1.13e-02	2.15e-01	9.42e-01
MAP3K8-(TPL2)-dependent-MAPK1/3-activation	15	4.23e-01	6.26e-01	0.19100	0.038500	1.87e-01	7.97e-01	2.10e-01
G-alpha-(s)-signalling-events	67	3.59e-02	1.40e-01	0.19100	0.112000	-1.54e-01	1.13e-01	2.90e-02
Termination-of-translesion-DNA-synthesis	27	2.06e-01	4.21e-01	0.19100	-0.067700	-1.78e-01	5.43e-01	1.09e-01
Disassembly-of-the-destruction-complex-and-recruitment-of-AXIN-to-the-membrane	26	2.27e-01	4.53e-01	0.18900	0.050600	1.83e-01	6.55e-01	1.07e-01
MyD88-cascade-initiated-on-plasma-membrane	74	1.71e-02	8.23e-02	0.18900	0.018100	1.88e-01	7.88e-01	5.11e-03
Toll-Like-Receptor-10-(TLR10)-Cascade	74	1.71e-02	8.23e-02	0.18900	0.018100	1.88e-01	7.88e-01	5.11e-03
Toll-Like-Receptor-5-(TLR5)-Cascade	74	1.71e-02	8.23e-02	0.18900	0.018100	1.88e-01	7.88e-01	5.11e-03
Transcriptional-regulation-by-the-AP-2-(TFAP2)-family-of-transcription-factors	23	2.62e-01	4.87e-01	0.18900	-0.081100	-1.71e-01	5.01e-01	1.56e-01
Class-I-peroxisomal-membrane-protein-import	18	4.01e-01	6.06e-01	0.18900	-0.058600	1.80e-01	6.67e-01	1.87e-01
Autophagy	117	3.70e-03	2.64e-02	0.18800	-0.127000	1.39e-01	1.78e-02	9.70e-03
Translocation-of-SLC2A4-(GLUT4)-to-the-plasma-membrane	49	5.87e-02	1.98e-01	0.18800	0.098400	1.60e-01	2.34e-01	5.32e-02
Regulation-of-Insulin-like-Growth-Factor-(IGF)-transport-and-uptake-by-Insulin-like-Growth-Factor-Binding-Proteins-(IGFBPs)	68	3.90e-02	1.47e-01	0.18700	0.122000	-1.42e-01	8.25e-02	4.26e-02
DARPP-32-events	22	2.81e-01	5.08e-01	0.18700	0.095100	1.61e-01	4.40e-01	1.90e-01
Nervous-system-development	408	1.77e-10	8.38e-09	0.18600	-0.087600	-1.64e-01	2.59e-03	1.58e-08
Frs2-mediated-activation	11	5.51e-01	7.23e-01	0.18600	-0.183000	-3.17e-02	2.92e-01	8.56e-01
Signaling-by-BMP	18	4.24e-01	6.28e-01	0.18600	-0.156000	1.02e-01	2.53e-01	4.53e-01
CREB1-phosphorylation-through-NMDA-receptor-mediated-activation-of-RAS-signaling	20	3.77e-01	5.89e-01	0.18600	-0.174000	6.47e-02	1.78e-01	6.17e-01
Pausing-and-recovery-of-Tat-mediated-HIV-elongation	27	2.22e-01	4.46e-01	0.18500	-0.083200	-1.65e-01	4.55e-01	1.38e-01
Tat-mediated-HIV-elongation-arrest-and-recovery	27	2.22e-01	4.46e-01	0.18500	-0.083200	-1.65e-01	4.55e-01	1.38e-01
Endosomal-Sorting-Complex-Required-For-Transport-(ESCRT)	27	2.75e-01	5.03e-01	0.18500	-0.170000	7.30e-02	1.28e-01	5.11e-01
mRNA-Splicing---Minor-Pathway	50	5.96e-02	1.99e-01	0.18400	-0.138000	-1.22e-01	9.17e-02	1.35e-01
TRAF6-mediated-induction-of-NFkB-and-MAP-kinases-upon-TLR7/8-or-9-activation	77	1.90e-02	8.98e-02	0.18400	0.005460	1.84e-01	9.34e-01	5.24e-03
Platelet-homeostasis	58	6.80e-02	2.17e-01	0.18400	0.104000	-1.52e-01	1.73e-01	4.53e-02
Transcriptional-Regulation-by-E2F6	27	2.19e-01	4.43e-01	0.18400	0.117000	1.42e-01	2.92e-01	2.02e-01
Amyloid-fiber-formation	31	1.81e-01	3.91e-01	0.18400	-0.079100	-1.66e-01	4.46e-01	1.10e-01
Macroautophagy	106	7.77e-03	4.59e-02	0.18400	-0.109000	1.48e-01	5.20e-02	8.82e-03
Hemostasis	373	4.84e-08	1.99e-06	0.18400	0.094400	-1.57e-01	1.88e-03	2.15e-07
RAB-geranylgeranylation	45	9.57e-02	2.68e-01	0.18400	0.023200	1.82e-01	7.88e-01	3.47e-02
HIV-elongation-arrest-and-recovery	29	1.97e-01	4.11e-01	0.18400	-0.127000	-1.32e-01	2.37e-01	2.17e-01
Pausing-and-recovery-of-HIV-elongation	29	1.97e-01	4.11e-01	0.18400	-0.127000	-1.32e-01	2.37e-01	2.17e-01
Ub-specific-processing-proteases	148	9.38e-04	9.26e-03	0.18300	-0.172000	6.39e-02	3.15e-04	1.81e-01
Apoptotic-factor-mediated-response	14	5.25e-01	7.07e-01	0.18300	0.152000	-1.01e-01	3.23e-01	5.12e-01
Transport-of-vitamins,-nucleosides,-and-related-molecules	25	2.91e-01	5.21e-01	0.18300	-0.022600	1.82e-01	8.45e-01	1.16e-01
Switching-of-origins-to-a-post-replicative-state	77	1.66e-02	8.18e-02	0.18300	-0.174000	-5.60e-02	8.39e-03	3.96e-01
Ca-dependent-events	31	2.00e-01	4.13e-01	0.18300	0.025900	1.81e-01	8.03e-01	8.15e-02
Class-B/2-(Secretin-family-receptors)	33	2.00e-01	4.13e-01	0.18100	0.180000	-1.93e-02	7.30e-02	8.48e-01
Synthesis-of-glycosylphosphatidylinositol-(GPI)	15	4.46e-01	6.44e-01	0.18100	0.088800	1.58e-01	5.52e-01	2.90e-01
EPH-Ephrin-signaling	70	3.13e-02	1.28e-01	0.18100	-0.001380	-1.81e-01	9.84e-01	8.88e-03
Signaling-by-Erythropoietin	23	3.30e-01	5.57e-01	0.18100	-0.179000	2.54e-02	1.37e-01	8.33e-01
PKA-activation	14	4.71e-01	6.63e-01	0.18000	0.140000	1.13e-01	3.64e-01	4.65e-01
Visual-phototransduction	40	1.35e-01	3.31e-01	0.18000	-0.021700	-1.79e-01	8.12e-01	5.08e-02
Signaling-by-NTRK3-(TRKC)	15	5.02e-01	6.90e-01	0.17900	0.171000	-5.39e-02	2.51e-01	7.18e-01
Anti-inflammatory-response-favouring-Leishmania-parasite-infection	68	4.39e-02	1.61e-01	0.17900	0.048600	-1.73e-01	4.89e-01	1.39e-02
Leishmania-parasite-growth-and-survival	68	4.39e-02	1.61e-01	0.17900	0.048600	-1.73e-01	4.89e-01	1.39e-02
Integrin-signaling	23	3.65e-01	5.77e-01	0.17900	0.129000	-1.25e-01	2.84e-01	3.01e-01
ER-Quality-Control-Compartment-(ERQC)	20	4.15e-01	6.18e-01	0.17900	-0.099900	1.49e-01	4.39e-01	2.50e-01
Toll-Like-Receptor-9-(TLR9)-Cascade	82	1.93e-02	9.09e-02	0.17900	0.002860	1.79e-01	9.64e-01	5.26e-03
NRIF-signals-cell-death-from-the-nucleus	14	5.02e-01	6.90e-01	0.17800	-0.026800	-1.76e-01	8.62e-01	2.55e-01
Metabolism-of-RNA	613	5.38e-14	5.10e-12	0.17700	-0.136000	-1.15e-01	1.47e-08	1.70e-06
Gastrin-CREB-signalling-pathway-via-PKC-and-MAPK	16	4.53e-01	6.49e-01	0.17700	-0.171000	-4.34e-02	2.35e-01	7.64e-01
Tie2-Signaling	15	4.62e-01	6.57e-01	0.17600	0.137000	1.10e-01	3.57e-01	4.60e-01
MET-activates-PTK2-signaling	13	5.15e-01	7.00e-01	0.17600	-0.148000	-9.45e-02	3.55e-01	5.55e-01
Signaling-by-high-kinase-activity-BRAF-mutants	29	2.94e-01	5.23e-01	0.17600	0.144000	-1.00e-01	1.79e-01	3.51e-01
Downstream-signaling-of-activated-FGFR1	18	4.58e-01	6.54e-01	0.17600	-0.064700	1.63e-01	6.35e-01	2.31e-01
PECAM1-interactions	11	5.98e-01	7.56e-01	0.17500	-0.003990	-1.75e-01	9.82e-01	3.14e-01
Signaling-by-ERBB2-in-Cancer	22	3.70e-01	5.82e-01	0.17500	0.174000	-2.32e-02	1.59e-01	8.51e-01
Golgi-to-ER-retrograde-transport	88	1.24e-02	6.57e-02	0.17500	0.155000	8.08e-02	1.19e-02	1.91e-01
Nicotinate-metabolism	22	3.32e-01	5.58e-01	0.17400	-0.142000	-1.01e-01	2.51e-01	4.11e-01
mRNA-Splicing---Major-Pathway	170	2.40e-04	3.19e-03	0.17300	-0.139000	-1.03e-01	1.79e-03	2.13e-02
Export-of-Viral-Ribonucleoproteins-from-Nucleus	29	2.99e-01	5.29e-01	0.17300	-0.157000	7.11e-02	1.43e-01	5.08e-01
Metabolism-of-water-soluble-vitamins-and-cofactors	92	1.27e-02	6.65e-02	0.17300	0.056200	1.63e-01	3.52e-01	6.95e-03
TRAF6-mediated-IRF7-activation	14	5.04e-01	6.91e-01	0.17200	-0.144000	-9.44e-02	3.52e-01	5.41e-01
G-alpha-(q)-signalling-events	92	2.23e-02	9.99e-02	0.17200	0.064100	-1.59e-01	2.89e-01	8.32e-03
Formation-of-HIV-1-elongation-complex-containing-HIV-1-Tat	39	1.63e-01	3.69e-01	0.17100	-0.046000	-1.65e-01	6.20e-01	7.52e-02
HIV-Transcription-Elongation	39	1.63e-01	3.69e-01	0.17100	-0.046000	-1.65e-01	6.20e-01	7.52e-02
Tat-mediated-elongation-of-the-HIV-1-transcript	39	1.63e-01	3.69e-01	0.17100	-0.046000	-1.65e-01	6.20e-01	7.52e-02
Chromatin-modifying-enzymes	188	6.34e-04	7.11e-03	0.17100	-0.111000	1.30e-01	9.10e-03	2.21e-03
Chromatin-organization	188	6.34e-04	7.11e-03	0.17100	-0.111000	1.30e-01	9.10e-03	2.21e-03
MAP2K-and-MAPK-activation	33	2.71e-01	4.97e-01	0.17100	0.114000	-1.27e-01	2.57e-01	2.08e-01
Synthesis-of-PIPs-at-the-early-endosome-membrane	16	4.65e-01	6.58e-01	0.17000	0.106000	1.33e-01	4.63e-01	3.58e-01
DNA-Damage/Telomere-Stress-Induced-Senescence	23	4.00e-01	6.06e-01	0.17000	0.148000	-8.30e-02	2.20e-01	4.91e-01
Interleukin-3,-Interleukin-5-and-GM-CSF-signaling	31	2.94e-01	5.24e-01	0.17000	-0.141000	9.49e-02	1.76e-01	3.61e-01
Interleukin-2-family-signaling	28	2.83e-01	5.11e-01	0.16900	0.032700	1.66e-01	7.65e-01	1.28e-01
Ca2+-pathway	48	1.10e-01	2.94e-01	0.16900	0.159000	5.73e-02	5.62e-02	4.93e-01
MyD88-dependent-cascade-initiated-on-endosome	78	3.51e-02	1.38e-01	0.16900	-0.004420	1.69e-01	9.46e-01	9.85e-03
Toll-Like-Receptor-7/8-(TLR7/8)-Cascade	78	3.51e-02	1.38e-01	0.16900	-0.004420	1.69e-01	9.46e-01	9.85e-03
Erythropoietin-activates-RAS	12	5.66e-01	7.31e-01	0.16900	-0.136000	-1.01e-01	4.16e-01	5.44e-01
Regulation-of-cholesterol-biosynthesis-by-SREBP-(SREBF)	51	9.29e-02	2.65e-01	0.16900	0.079300	1.49e-01	3.28e-01	6.57e-02
Processing-of-Intronless-Pre-mRNAs	17	4.46e-01	6.44e-01	0.16900	-0.117000	-1.22e-01	4.05e-01	3.84e-01
Cellular-response-to-heat-stress	90	2.97e-02	1.24e-01	0.16900	-0.145000	8.61e-02	1.75e-02	1.59e-01
Negative-regulation-of-FGFR3-signaling	21	4.38e-01	6.39e-01	0.16900	-0.085300	1.45e-01	4.99e-01	2.49e-01
Fatty-acyl-CoA-biosynthesis	25	3.44e-01	5.64e-01	0.16800	0.168000	-2.77e-03	1.45e-01	9.81e-01
Nonhomologous-End-Joining-(NHEJ)	29	2.70e-01	4.97e-01	0.16800	0.161000	4.76e-02	1.33e-01	6.57e-01
Diseases-of-glycosylation	102	1.71e-02	8.23e-02	0.16800	0.055200	-1.59e-01	3.36e-01	5.63e-03
Transport-of-Ribonucleoproteins-into-the-Host-Nucleus	28	3.29e-01	5.55e-01	0.16800	-0.061400	1.56e-01	5.74e-01	1.52e-01
SHC1-events-in-ERBB2-signaling	18	4.82e-01	6.73e-01	0.16800	0.162000	-4.28e-02	2.33e-01	7.53e-01
RNA-Polymerase-II-Transcription-Termination	60	6.10e-02	2.01e-01	0.16800	-0.110000	-1.27e-01	1.41e-01	9.00e-02
Positive-epigenetic-regulation-of-rRNA-expression	45	1.35e-01	3.31e-01	0.16800	-0.162000	-4.27e-02	6.01e-02	6.21e-01
TGF-beta-receptor-signaling-activates-SMADs	31	2.54e-01	4.85e-01	0.16700	-0.163000	-3.84e-02	1.17e-01	7.11e-01
NF-kB-activation-through-FADD/RIP-1-pathway-mediated-by-caspase-8-and--10	11	6.37e-01	7.87e-01	0.16700	0.165000	-2.49e-02	3.43e-01	8.86e-01
SHC-mediated-cascade:FGFR3	11	6.47e-01	7.94e-01	0.16700	-0.057100	1.57e-01	7.43e-01	3.67e-01
Synthesis-of-substrates-in-N-glycan-biosythesis	51	1.45e-01	3.47e-01	0.16700	0.122000	-1.14e-01	1.32e-01	1.59e-01
WNT-ligand-biogenesis-and-trafficking	11	6.31e-01	7.82e-01	0.16700	-0.004220	1.67e-01	9.81e-01	3.39e-01
Glucagon-signaling-in-metabolic-regulation	22	4.34e-01	6.34e-01	0.16700	0.132000	-1.01e-01	2.83e-01	4.11e-01
RA-biosynthesis-pathway	12	6.36e-01	7.87e-01	0.16700	0.120000	-1.15e-01	4.71e-01	4.90e-01
Synthesis-of-PIPs-at-the-plasma-membrane	51	1.04e-01	2.85e-01	0.16600	0.056000	1.57e-01	4.90e-01	5.30e-02
Glucose-metabolism	74	5.49e-02	1.88e-01	0.16600	-0.047900	1.59e-01	4.77e-01	1.82e-02
Extension-of-Telomeres	34	2.22e-01	4.46e-01	0.16600	-0.058600	-1.55e-01	5.55e-01	1.18e-01
Telomere-Maintenance	34	2.22e-01	4.46e-01	0.16600	-0.058600	-1.55e-01	5.55e-01	1.18e-01
Deubiquitination	211	3.63e-04	4.45e-03	0.16500	-0.150000	7.01e-02	1.89e-04	8.05e-02
Metabolism-of-steroids	94	1.44e-02	7.33e-02	0.16500	0.121000	1.13e-01	4.37e-02	5.92e-02
Hedgehog-'on'-state	75	3.79e-02	1.45e-01	0.16500	-0.155000	-5.76e-02	2.09e-02	3.89e-01
RORA-activates-gene-expression	17	5.33e-01	7.12e-01	0.16500	-0.120000	1.13e-01	3.91e-01	4.21e-01
Post-translational-protein-phosphorylation	63	9.86e-02	2.75e-01	0.16500	0.117000	-1.16e-01	1.09e-01	1.11e-01
Class-I-MHC-mediated-antigen-processing-&-presentation	307	1.08e-05	2.78e-04	0.16400	-0.057400	1.54e-01	8.55e-02	4.00e-06
Pentose-phosphate-pathway	10	6.88e-01	8.16e-01	0.16400	0.146000	-7.53e-02	4.25e-01	6.80e-01
Golgi-Associated-Vesicle-Biogenesis	50	1.39e-01	3.36e-01	0.16400	0.162000	-2.13e-02	4.71e-02	7.95e-01
ERK/MAPK-targets	21	4.64e-01	6.58e-01	0.16300	-0.098700	1.30e-01	4.34e-01	3.02e-01
PKA-mediated-phosphorylation-of-CREB	16	5.03e-01	6.91e-01	0.16300	0.053400	1.54e-01	7.11e-01	2.85e-01
Nuclear-Pore-Complex-(NPC)-Disassembly	29	3.48e-01	5.65e-01	0.16300	-0.086500	1.38e-01	4.20e-01	2.00e-01
Activation-of-the-pre-replicative-complex	22	4.50e-01	6.47e-01	0.16200	0.084700	-1.39e-01	4.92e-01	2.61e-01
Metabolism-of-lipids	518	3.62e-10	1.60e-08	0.16200	0.101000	1.27e-01	1.04e-04	8.99e-07
Formation-of-HIV-elongation-complex-in-the-absence-of-HIV-Tat	41	1.71e-01	3.76e-01	0.16200	-0.078800	-1.42e-01	3.83e-01	1.16e-01
Late-endosomal-microautophagy	26	3.51e-01	5.66e-01	0.16200	-0.161000	-1.36e-02	1.55e-01	9.04e-01
Formation-of-the-beta-catenin:TCF-transactivating-complex	27	3.38e-01	5.63e-01	0.16200	-0.161000	-1.50e-02	1.48e-01	8.93e-01
MAPK-family-signaling-cascades	212	1.42e-04	2.15e-03	0.16100	-0.145000	-7.11e-02	2.97e-04	7.54e-02
COPII-mediated-vesicle-transport	56	9.44e-02	2.67e-01	0.16100	0.067300	1.46e-01	3.84e-01	5.83e-02
LDL-clearance	14	5.77e-01	7.37e-01	0.16100	-0.161000	-2.69e-03	2.97e-01	9.86e-01
Protein-methylation	12	5.99e-01	7.56e-01	0.16100	-0.135000	-8.78e-02	4.19e-01	5.99e-01
Constitutive-Signaling-by-Aberrant-PI3K-in-Cancer	40	2.27e-01	4.53e-01	0.16100	-0.155000	4.34e-02	9.04e-02	6.35e-01
C-type-lectin-receptors-(CLRs)	102	1.64e-02	8.14e-02	0.16100	-0.157000	-3.31e-02	6.18e-03	5.65e-01
Signaling-by-FGFR4	30	3.46e-01	5.65e-01	0.16100	-0.090300	1.33e-01	3.92e-01	2.08e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-1-Promoter	27	3.39e-01	5.63e-01	0.16000	-0.158000	-2.64e-02	1.55e-01	8.12e-01
Interconversion-of-nucleotide-di--and-triphosphates	20	4.96e-01	6.85e-01	0.16000	-0.094500	1.29e-01	4.65e-01	3.17e-01
ROS-and-RNS-production-in-phagocytes	26	3.50e-01	5.65e-01	0.16000	-0.035900	-1.56e-01	7.52e-01	1.69e-01
Arachidonic-acid-metabolism	26	3.85e-01	5.95e-01	0.16000	0.154000	-4.31e-02	1.74e-01	7.04e-01
O-linked-glycosylation-of-mucins	27	3.75e-01	5.87e-01	0.16000	0.050500	-1.52e-01	6.50e-01	1.73e-01
CaM-pathway	29	3.36e-01	5.61e-01	0.15900	-0.017500	1.59e-01	8.71e-01	1.40e-01
Calmodulin-induced-events	29	3.36e-01	5.61e-01	0.15900	-0.017500	1.59e-01	8.71e-01	1.40e-01
SHC-mediated-cascade:FGFR1	10	6.63e-01	8.03e-01	0.15900	0.060500	1.47e-01	7.40e-01	4.20e-01
Interleukin-receptor-SHC-signaling	18	5.11e-01	6.98e-01	0.15900	-0.024100	1.58e-01	8.60e-01	2.47e-01
RHO-GTPases-activate-CIT	16	5.45e-01	7.22e-01	0.15900	0.009540	-1.59e-01	9.47e-01	2.71e-01
Extra-nuclear-estrogen-signaling	58	1.29e-01	3.26e-01	0.15900	0.066200	-1.45e-01	3.84e-01	5.69e-02
Collagen-degradation	20	4.53e-01	6.49e-01	0.15900	-0.028100	-1.57e-01	8.28e-01	2.26e-01
HCMV-Late-Events	49	1.86e-01	3.99e-01	0.15900	-0.101000	1.22e-01	2.21e-01	1.39e-01
Signaling-by-WNT-in-cancer	28	3.43e-01	5.64e-01	0.15900	0.004110	1.59e-01	9.70e-01	1.47e-01
Transport-of-Mature-mRNA-Derived-from-an-Intronless-Transcript	37	2.65e-01	4.90e-01	0.15800	-0.152000	4.53e-02	1.10e-01	6.34e-01
MyD88:MAL(TIRAP)-cascade-initiated-on-plasma-membrane	81	4.58e-02	1.63e-01	0.15800	0.005690	1.58e-01	9.30e-01	1.39e-02
Toll-Like-Receptor-2-(TLR2)-Cascade	81	4.58e-02	1.63e-01	0.15800	0.005690	1.58e-01	9.30e-01	1.39e-02
Toll-Like-Receptor-TLR1:TLR2-Cascade	81	4.58e-02	1.63e-01	0.15800	0.005690	1.58e-01	9.30e-01	1.39e-02
Toll-Like-Receptor-TLR6:TLR2-Cascade	81	4.58e-02	1.63e-01	0.15800	0.005690	1.58e-01	9.30e-01	1.39e-02
Formation-of-Senescence-Associated-Heterochromatin-Foci-(SAHF)	10	6.77e-01	8.05e-01	0.15800	-0.031000	-1.55e-01	8.65e-01	3.98e-01
O-linked-glycosylation	63	1.06e-01	2.89e-01	0.15700	0.038500	-1.53e-01	5.97e-01	3.63e-02
Signaling-by-FGFR2-in-disease	30	3.28e-01	5.55e-01	0.15600	-0.156000	-7.35e-03	1.39e-01	9.44e-01
mRNA-Splicing	178	8.31e-04	8.54e-03	0.15600	-0.122000	-9.76e-02	5.28e-03	2.52e-02
FCGR3A-mediated-phagocytosis	49	1.48e-01	3.48e-01	0.15600	-0.054900	-1.46e-01	5.07e-01	7.77e-02
Leishmania-phagocytosis	49	1.48e-01	3.48e-01	0.15600	-0.054900	-1.46e-01	5.07e-01	7.77e-02
Parasite-infection	49	1.48e-01	3.48e-01	0.15600	-0.054900	-1.46e-01	5.07e-01	7.77e-02
Regulation-of-insulin-secretion	52	1.52e-01	3.53e-01	0.15500	0.155000	-3.52e-03	5.28e-02	9.65e-01
Negative-regulation-of-MET-activity	16	5.84e-01	7.44e-01	0.15500	-0.068200	1.40e-01	6.37e-01	3.34e-01
Fc-epsilon-receptor-(FCERI)-signaling	113	1.99e-02	9.28e-02	0.15500	-0.152000	3.32e-02	5.45e-03	5.43e-01
N-glycan-trimming-in-the-ER-and-Calnexin/Calreticulin-cycle	34	3.29e-01	5.55e-01	0.15500	-0.115000	1.04e-01	2.47e-01	2.92e-01
IRS-related-events-triggered-by-IGF1R	32	3.18e-01	5.49e-01	0.15500	-0.012800	1.55e-01	9.00e-01	1.30e-01
Cytosolic-sensors-of-pathogen-associated-DNA	57	1.05e-01	2.86e-01	0.15400	-0.109000	-1.09e-01	1.56e-01	1.54e-01
trans-Golgi-Network-Vesicle-Budding	64	1.20e-01	3.12e-01	0.15400	0.142000	-5.83e-02	4.92e-02	4.21e-01
Sulfur-amino-acid-metabolism	19	5.27e-01	7.09e-01	0.15400	-0.045600	1.47e-01	7.31e-01	2.68e-01
SUMOylation-of-DNA-damage-response-and-repair-proteins	67	7.39e-02	2.32e-01	0.15300	0.092700	1.22e-01	1.90e-01	8.38e-02
mRNA-3'-end-processing	53	1.28e-01	3.25e-01	0.15300	-0.094800	-1.20e-01	2.33e-01	1.30e-01
The-NLRP3-inflammasome	11	6.88e-01	8.16e-01	0.15300	0.149000	-3.35e-02	3.91e-01	8.47e-01
DNA-Damage-Recognition-in-GG-NER	37	2.93e-01	5.23e-01	0.15300	-0.145000	4.93e-02	1.28e-01	6.04e-01
TP53-Regulates-Transcription-of-Cell-Death-Genes	28	4.10e-01	6.13e-01	0.15300	0.119000	-9.65e-02	2.78e-01	3.77e-01
Transcriptional-regulation-by-RUNX1	151	4.45e-03	3.05e-02	0.15300	-0.151000	-2.12e-02	1.38e-03	6.53e-01
NEP/NS2-Interacts-with-the-Cellular-Export-Machinery	28	4.08e-01	6.11e-01	0.15200	-0.132000	7.57e-02	2.26e-01	4.88e-01
Surfactant-metabolism	12	6.37e-01	7.87e-01	0.15200	-0.058800	-1.40e-01	7.24e-01	4.00e-01
Synaptic-adhesion-like-molecules	11	7.02e-01	8.28e-01	0.15100	0.139000	-5.90e-02	4.23e-01	7.35e-01
Signaling-by-PDGFR-in-disease	18	5.31e-01	7.12e-01	0.15100	0.011500	1.51e-01	9.33e-01	2.68e-01
Metabolism-of-cofactors	17	5.88e-01	7.48e-01	0.15100	-0.117000	9.61e-02	4.05e-01	4.93e-01
SUMOylation-of-chromatin-organization-proteins	51	1.48e-01	3.48e-01	0.15100	0.077200	1.30e-01	3.41e-01	1.09e-01
TCF-dependent-signaling-in-response-to-WNT	139	9.70e-03	5.44e-02	0.15100	-0.150000	1.96e-02	2.34e-03	6.91e-01
Anchoring-of-the-basal-body-to-the-plasma-membrane	83	6.52e-02	2.10e-01	0.15100	0.147000	-3.36e-02	2.05e-02	5.97e-01
MHC-class-II-antigen-presentation	73	9.52e-02	2.67e-01	0.15100	-0.142000	5.02e-02	3.55e-02	4.59e-01
Metabolism-of-non-coding-RNA	47	1.95e-01	4.09e-01	0.15100	-0.151000	-8.63e-03	7.39e-02	9.19e-01
snRNP-Assembly	47	1.95e-01	4.09e-01	0.15100	-0.151000	-8.63e-03	7.39e-02	9.19e-01
Apoptotic-cleavage-of-cellular-proteins	31	3.34e-01	5.60e-01	0.15100	-0.022800	-1.49e-01	8.27e-01	1.51e-01
Activation-of-BH3-only-proteins	22	4.58e-01	6.54e-01	0.15100	0.149000	2.51e-02	2.28e-01	8.38e-01
RAF/MAP-kinase-cascade	177	1.61e-03	1.29e-02	0.15100	-0.139000	-5.79e-02	1.46e-03	1.85e-01
RNA-Polymerase-I-Promoter-Clearance	49	1.63e-01	3.69e-01	0.15000	-0.132000	-7.27e-02	1.11e-01	3.79e-01
RNA-Polymerase-I-Transcription	49	1.63e-01	3.69e-01	0.15000	-0.132000	-7.27e-02	1.11e-01	3.79e-01
RMTs-methylate-histone-arginines	28	3.87e-01	5.95e-01	0.15000	-0.150000	2.94e-03	1.70e-01	9.79e-01
Inflammasomes	13	6.71e-01	8.03e-01	0.15000	0.103000	-1.09e-01	5.22e-01	4.94e-01
Signal-transduction-by-L1	20	4.86e-01	6.77e-01	0.15000	0.052500	1.40e-01	6.84e-01	2.78e-01
Deadenylation-dependent-mRNA-decay	51	1.59e-01	3.64e-01	0.15000	-0.139000	-5.61e-02	8.70e-02	4.89e-01
Plasma-lipoprotein-assembly,-remodeling,-and-clearance	42	2.81e-01	5.08e-01	0.14900	-0.101000	1.10e-01	2.56e-01	2.20e-01
Ion-homeostasis	36	3.27e-01	5.55e-01	0.14800	-0.049700	1.40e-01	6.06e-01	1.48e-01
Regulation-of-actin-dynamics-for-phagocytic-cup-formation	51	1.66e-01	3.71e-01	0.14800	-0.053200	-1.38e-01	5.11e-01	8.84e-02
Resolution-of-Abasic-Sites-(AP-sites)	33	3.09e-01	5.38e-01	0.14800	-0.132000	-6.65e-02	1.90e-01	5.09e-01
RNA-Polymerase-I-Transcription-Initiation	47	1.88e-01	4.01e-01	0.14700	-0.131000	-6.86e-02	1.22e-01	4.16e-01
NCAM-signaling-for-neurite-out-growth	43	2.19e-01	4.43e-01	0.14700	-0.066200	-1.31e-01	4.53e-01	1.37e-01
PKA-activation-in-glucagon-signalling	13	6.51e-01	7.96e-01	0.14700	0.006970	1.47e-01	9.65e-01	3.59e-01
PTEN-Regulation	131	1.70e-02	8.23e-02	0.14600	-0.144000	2.36e-02	4.39e-03	6.42e-01
Degradation-of-beta-catenin-by-the-destruction-complex	77	7.71e-02	2.40e-01	0.14600	-0.144000	-2.56e-02	2.92e-02	6.98e-01
Telomere-C-strand-(Lagging-Strand)-Synthesis	20	5.33e-01	7.12e-01	0.14600	0.020200	-1.45e-01	8.76e-01	2.63e-01
NS1-Mediated-Effects-on-Host-Pathways	34	3.73e-01	5.85e-01	0.14600	-0.111000	9.43e-02	2.62e-01	3.42e-01
MAPK1/MAPK3-signaling	181	2.17e-03	1.65e-02	0.14600	-0.136000	-5.20e-02	1.62e-03	2.29e-01
RHO-GTPases-Activate-NADPH-Oxidases	16	6.21e-01	7.75e-01	0.14600	-0.134000	5.78e-02	3.55e-01	6.89e-01
Oxidative-Stress-Induced-Senescence	58	1.36e-01	3.32e-01	0.14500	0.064700	1.30e-01	3.94e-01	8.68e-02
Elevation-of-cytosolic-Ca2+-levels	11	7.29e-01	8.36e-01	0.14500	0.101000	-1.04e-01	5.60e-01	5.50e-01
Downregulation-of-ERBB2:ERBB3-signaling	11	7.08e-01	8.28e-01	0.14500	0.010200	-1.45e-01	9.54e-01	4.06e-01
Transcriptional-activity-of-SMAD2/SMAD3:SMAD4-heterotrimer	40	3.07e-01	5.38e-01	0.14500	-0.054500	1.34e-01	5.51e-01	1.42e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-2-Promoter	26	4.33e-01	6.33e-01	0.14500	-0.144000	-1.13e-02	2.03e-01	9.21e-01
Mismatch-Repair	13	6.69e-01	8.03e-01	0.14500	0.144000	-1.91e-02	3.70e-01	9.05e-01
Intrinsic-Pathway-for-Apoptosis	40	3.09e-01	5.38e-01	0.14500	0.134000	-5.58e-02	1.44e-01	5.42e-01
NoRC-negatively-regulates-rRNA-expression	45	2.15e-01	4.36e-01	0.14500	-0.069400	-1.27e-01	4.21e-01	1.41e-01
AURKA-Activation-by-TPX2	61	1.76e-01	3.82e-01	0.14400	0.126000	-6.88e-02	8.89e-02	3.53e-01
Loss-of-Nlp-from-mitotic-centrosomes	61	1.76e-01	3.82e-01	0.14400	0.126000	-6.88e-02	8.89e-02	3.53e-01
Loss-of-proteins-required-for-interphase-microtubule-organization-from-the-centrosome	61	1.76e-01	3.82e-01	0.14400	0.126000	-6.88e-02	8.89e-02	3.53e-01
Retrograde-transport-at-the-Trans-Golgi-Network	45	2.29e-01	4.54e-01	0.14400	0.039500	1.38e-01	6.47e-01	1.09e-01
Signaling-by-NOTCH	156	5.60e-03	3.63e-02	0.14300	-0.127000	-6.57e-02	6.18e-03	1.58e-01
Pre-NOTCH-Expression-and-Processing	46	2.48e-01	4.81e-01	0.14300	-0.142000	1.30e-02	9.51e-02	8.79e-01
Negative-regulation-of-FGFR1-signaling	20	5.52e-01	7.23e-01	0.14300	-0.027900	1.40e-01	8.29e-01	2.78e-01
ERBB2-Regulates-Cell-Motility	10	7.23e-01	8.34e-01	0.14200	0.135000	4.36e-02	4.59e-01	8.11e-01
Integration-of-energy-metabolism	78	8.84e-02	2.58e-01	0.14200	0.141000	1.65e-02	3.14e-02	8.02e-01
Signaling-by-PDGF	45	2.29e-01	4.54e-01	0.14200	-0.059100	-1.29e-01	4.93e-01	1.34e-01
RNA-Polymerase-III-Abortive-And-Retractive-Initiation	40	2.97e-01	5.27e-01	0.14200	-0.142000	1.75e-03	1.21e-01	9.85e-01
RNA-Polymerase-III-Transcription	40	2.97e-01	5.27e-01	0.14200	-0.142000	1.75e-03	1.21e-01	9.85e-01
Notch-HLH-transcription-pathway	27	4.73e-01	6.64e-01	0.14200	-0.123000	7.09e-02	2.71e-01	5.24e-01
Early-Phase-of-HIV-Life-Cycle	12	6.76e-01	8.05e-01	0.14100	0.127000	6.19e-02	4.46e-01	7.10e-01
Cell-recruitment-(pro-inflammatory-response)	16	6.23e-01	7.75e-01	0.14100	0.141000	-1.18e-02	3.30e-01	9.35e-01
Purinergic-signaling-in-leishmaniasis-infection	16	6.23e-01	7.75e-01	0.14100	0.141000	-1.18e-02	3.30e-01	9.35e-01
EGFR-downregulation	23	5.21e-01	7.05e-01	0.14100	-0.136000	3.71e-02	2.60e-01	7.58e-01
Regulation-of-beta-cell-development	17	6.27e-01	7.78e-01	0.14000	-0.126000	6.24e-02	3.69e-01	6.56e-01
Signaling-by-FGFR4-in-disease	10	7.64e-01	8.53e-01	0.14000	-0.080600	1.14e-01	6.59e-01	5.31e-01
PRC2-methylates-histones-and-DNA	11	7.45e-01	8.40e-01	0.14000	-0.087600	1.09e-01	6.15e-01	5.31e-01
TBC/RABGAPs	41	3.04e-01	5.36e-01	0.14000	-0.011800	1.39e-01	8.96e-01	1.23e-01
Signaling-by-NOTCH3	42	2.64e-01	4.90e-01	0.14000	-0.058500	-1.27e-01	5.12e-01	1.55e-01
Signaling-by-ERBB2-KD-Mutants	21	5.32e-01	7.12e-01	0.14000	0.139000	1.45e-02	2.71e-01	9.09e-01
Platelet-Aggregation-(Plug-Formation)	24	5.29e-01	7.11e-01	0.14000	0.107000	-8.93e-02	3.64e-01	4.49e-01
ADORA2B-mediated-anti-inflammatory-cytokines-production	44	3.12e-01	5.41e-01	0.13900	0.093300	-1.04e-01	2.85e-01	2.35e-01
mRNA-Capping	29	4.28e-01	6.30e-01	0.13900	0.000434	-1.39e-01	9.97e-01	1.95e-01
Transport-of-bile-salts-and-organic-acids,-metal-ions-and-amine-compounds	34	3.41e-01	5.64e-01	0.13900	0.124000	6.32e-02	2.11e-01	5.24e-01
PI-Metabolism	74	9.53e-02	2.67e-01	0.13900	0.091000	1.04e-01	1.76e-01	1.21e-01
Lysosome-Vesicle-Biogenesis	27	4.40e-01	6.40e-01	0.13800	-0.037600	-1.33e-01	7.36e-01	2.32e-01
Sphingolipid-metabolism	60	1.97e-01	4.11e-01	0.13800	0.131000	-4.32e-02	7.89e-02	5.64e-01
Cyclin-D-associated-events-in-G1	36	3.93e-01	6.01e-01	0.13800	0.088000	-1.06e-01	3.61e-01	2.70e-01
G1-Phase	36	3.93e-01	6.01e-01	0.13800	0.088000	-1.06e-01	3.61e-01	2.70e-01
Downregulation-of-ERBB2-signaling	23	5.46e-01	7.22e-01	0.13800	0.064000	-1.22e-01	5.95e-01	3.11e-01
Post-NMDA-receptor-activation-events	45	2.98e-01	5.27e-01	0.13800	-0.041100	1.31e-01	6.34e-01	1.28e-01
Synthesis-of-DNA	97	5.00e-02	1.76e-01	0.13700	-0.113000	-7.71e-02	5.41e-02	1.90e-01
Phase-II---Conjugation-of-compounds	51	2.13e-01	4.34e-01	0.13700	0.056600	1.25e-01	4.85e-01	1.24e-01
Biosynthesis-of-the-N-glycan-precursor-(dolichol-lipid-linked-oligosaccharide,-LLO)-and-transfer-to-a-nascent-protein	64	1.99e-01	4.12e-01	0.13600	0.101000	-9.18e-02	1.64e-01	2.05e-01
Vpr-mediated-nuclear-import-of-PICs	30	4.61e-01	6.57e-01	0.13600	-0.060700	1.22e-01	5.65e-01	2.48e-01
Signaling-by-Type-1-Insulin-like-Growth-Factor-1-Receptor-(IGF1R)	34	3.98e-01	6.04e-01	0.13600	-0.019700	1.35e-01	8.43e-01	1.75e-01
Activation-of-NMDA-receptors-and-postsynaptic-events	52	2.69e-01	4.95e-01	0.13600	-0.073100	1.14e-01	3.63e-01	1.54e-01
Cyclin-A:Cdk2-associated-events-at-S-phase-entry	75	1.16e-01	3.03e-01	0.13600	-0.133000	-2.62e-02	4.65e-02	6.96e-01
Processing-of-DNA-double-strand-break-ends	47	3.10e-01	5.39e-01	0.13500	0.098300	-9.31e-02	2.44e-01	2.70e-01
DNA-Replication	99	5.13e-02	1.78e-01	0.13500	-0.114000	-7.24e-02	4.97e-02	2.14e-01
Synthesis-of-PE	11	7.45e-01	8.40e-01	0.13500	-0.024300	1.33e-01	8.89e-01	4.45e-01
Signaling-by-ERBB2-ECD-mutants	16	6.21e-01	7.75e-01	0.13500	0.122000	5.84e-02	3.99e-01	6.86e-01
Nucleotide-salvage	16	6.72e-01	8.03e-01	0.13500	0.091500	-9.95e-02	5.27e-01	4.91e-01
Purine-salvage	11	7.60e-01	8.50e-01	0.13500	0.078600	-1.10e-01	6.52e-01	5.28e-01
IGF1R-signaling-cascade	33	3.99e-01	6.04e-01	0.13500	0.008610	1.35e-01	9.32e-01	1.81e-01
Diseases-associated-with-glycosaminoglycan-metabolism	31	4.50e-01	6.47e-01	0.13500	0.042000	-1.28e-01	6.86e-01	2.18e-01
Role-of-LAT2/NTAL/LAB-on-calcium-mobilization	12	7.03e-01	8.28e-01	0.13500	0.125000	5.06e-02	4.55e-01	7.62e-01
IL-6-type-cytokine-receptor-ligand-interactions	10	7.46e-01	8.40e-01	0.13400	0.122000	5.49e-02	5.03e-01	7.64e-01
Nephrin-family-interactions	18	5.84e-01	7.44e-01	0.13400	-0.096000	-9.37e-02	4.81e-01	4.92e-01
Signaling-by-FGFR3	31	4.68e-01	6.61e-01	0.13400	-0.089800	9.96e-02	3.87e-01	3.37e-01
Fcgamma-receptor-(FCGR)-dependent-phagocytosis	73	1.27e-01	3.23e-01	0.13400	-0.032500	-1.30e-01	6.31e-01	5.51e-02
Prolonged-ERK-activation-events	13	7.24e-01	8.34e-01	0.13400	-0.117000	6.47e-02	4.64e-01	6.87e-01
VLDLR-internalisation-and-degradation	11	7.39e-01	8.40e-01	0.13400	-0.133000	-1.09e-02	4.44e-01	9.50e-01
Signal-regulatory-protein-family-interactions	11	7.45e-01	8.40e-01	0.13400	0.133000	-9.89e-03	4.44e-01	9.55e-01
PIP3-activates-AKT-signaling	218	4.90e-03	3.30e-02	0.13400	-0.118000	6.32e-02	2.81e-03	1.10e-01
HDR-through-MMEJ-(alt-NHEJ)	10	7.84e-01	8.66e-01	0.13400	0.099700	-8.89e-02	5.85e-01	6.27e-01
HATs-acetylate-histones	75	1.54e-01	3.58e-01	0.13400	-0.051000	1.23e-01	4.46e-01	6.50e-02
Factors-involved-in-megakaryocyte-development-and-platelet-production	83	1.04e-01	2.86e-01	0.13300	0.132000	1.53e-02	3.76e-02	8.09e-01
ZBP1(DAI)-mediated-induction-of-type-I-IFNs	19	6.19e-01	7.75e-01	0.13300	0.127000	-3.89e-02	3.37e-01	7.69e-01
Role-of-phospholipids-in-phagocytosis	22	5.87e-01	7.48e-01	0.13300	0.113000	-6.98e-02	3.60e-01	5.71e-01
TRAF3-dependent-IRF-activation-pathway	12	7.10e-01	8.28e-01	0.13300	-0.120000	-5.53e-02	4.70e-01	7.40e-01
BMAL1:CLOCK,NPAS2-activates-circadian-gene-expression	24	5.36e-01	7.14e-01	0.13300	-0.014100	1.32e-01	9.05e-01	2.64e-01
Cell-Cell-communication	77	1.12e-01	2.97e-01	0.13200	-0.119000	-5.73e-02	7.03e-02	3.85e-01
Interferon-Signaling	129	2.42e-02	1.06e-01	0.13200	-0.104000	-8.21e-02	4.21e-02	1.08e-01
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE	27	4.95e-01	6.85e-01	0.13200	0.008290	-1.32e-01	9.41e-01	2.36e-01
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE-during-HIV-infection	27	4.95e-01	6.85e-01	0.13200	0.008290	-1.32e-01	9.41e-01	2.36e-01
Epigenetic-regulation-of-gene-expression	82	1.03e-01	2.83e-01	0.13200	-0.123000	-4.67e-02	5.46e-02	4.65e-01
CLEC7A-(Dectin-1)-signaling	88	9.33e-02	2.65e-01	0.13200	-0.129000	-2.45e-02	3.65e-02	6.91e-01
Keratan-sulfate-biosynthesis	18	6.48e-01	7.94e-01	0.13100	-0.120000	5.42e-02	3.80e-01	6.91e-01
Disorders-of-transmembrane-transporters	120	5.45e-02	1.87e-01	0.13100	-0.124000	4.31e-02	1.92e-02	4.16e-01
Platelet-sensitization-by-LDL	14	6.70e-01	8.03e-01	0.13100	0.097400	8.80e-02	5.28e-01	5.69e-01
Transcriptional-regulation-by-RUNX2	97	7.17e-02	2.27e-01	0.13100	-0.126000	-3.51e-02	3.18e-02	5.51e-01
Transport-of-Mature-mRNAs-Derived-from-Intronless-Transcripts	38	3.96e-01	6.03e-01	0.13100	-0.125000	3.89e-02	1.83e-01	6.78e-01
ERKs-are-inactivated	12	7.13e-01	8.28e-01	0.13100	-0.109000	-7.17e-02	5.12e-01	6.67e-01
Base-Excision-Repair	39	3.32e-01	5.58e-01	0.13100	-0.101000	-8.34e-02	2.77e-01	3.68e-01
Resolution-of-D-Loop-Structures	17	6.71e-01	8.03e-01	0.13000	0.113000	-6.55e-02	4.22e-01	6.40e-01
Heparan-sulfate/heparin-(HS-GAG)-metabolism	35	4.25e-01	6.29e-01	0.13000	0.029600	-1.27e-01	7.62e-01	1.95e-01
Regulation-of-FZD-by-ubiquitination	13	7.40e-01	8.40e-01	0.13000	-0.065600	1.12e-01	6.82e-01	4.85e-01
TAK1-activates-NFkB-by-phosphorylation-and-activation-of-IKKs-complex	22	5.53e-01	7.23e-01	0.12800	0.114000	5.88e-02	3.55e-01	6.33e-01
PCNA-Dependent-Long-Patch-Base-Excision-Repair	19	6.54e-01	7.99e-01	0.12800	0.094200	-8.67e-02	4.77e-01	5.13e-01
MyD88-independent-TLR4-cascade	85	1.26e-01	3.22e-01	0.12800	-0.002560	1.28e-01	9.67e-01	4.24e-02
TRIF(TICAM1)-mediated-TLR4-signaling	85	1.26e-01	3.22e-01	0.12800	-0.002560	1.28e-01	9.67e-01	4.24e-02
Activation-of-gene-expression-by-SREBF-(SREBP)	38	3.68e-01	5.80e-01	0.12700	0.117000	5.00e-02	2.11e-01	5.94e-01
Infectious-disease	483	3.81e-06	1.15e-04	0.12700	-0.073100	-1.04e-01	6.43e-03	9.94e-05
Gap-filling-DNA-repair-synthesis-and-ligation-in-TC-NER	61	1.99e-01	4.12e-01	0.12700	-0.057600	-1.14e-01	4.37e-01	1.25e-01
STING-mediated-induction-of-host-immune-responses	12	7.61e-01	8.50e-01	0.12700	0.049600	-1.17e-01	7.66e-01	4.83e-01
TNF-signaling	38	4.29e-01	6.30e-01	0.12700	-0.110000	6.36e-02	2.41e-01	4.98e-01
SUMOylation-of-transcription-factors	15	6.71e-01	8.03e-01	0.12700	0.097800	8.04e-02	5.12e-01	5.90e-01
FLT3-Signaling	193	8.53e-03	4.94e-02	0.12600	-0.124000	-2.39e-02	3.06e-03	5.69e-01
Centrosome-maturation	70	2.15e-01	4.36e-01	0.12600	0.110000	-6.18e-02	1.12e-01	3.72e-01
Recruitment-of-mitotic-centrosome-proteins-and-complexes	70	2.15e-01	4.36e-01	0.12600	0.110000	-6.18e-02	1.12e-01	3.72e-01
Mismatch-repair-(MMR)-directed-by-MSH2:MSH6-(MutSalpha)	12	7.37e-01	8.40e-01	0.12600	0.121000	3.54e-02	4.68e-01	8.32e-01
Homologous-DNA-Pairing-and-Strand-Exchange	27	5.11e-01	6.98e-01	0.12600	0.123000	2.67e-02	2.69e-01	8.10e-01
Dual-incision-in-TC-NER	62	2.17e-01	4.40e-01	0.12600	-0.021500	-1.24e-01	7.70e-01	9.20e-02
Nuclear-import-of-Rev-protein	29	5.32e-01	7.12e-01	0.12500	-0.053500	1.13e-01	6.18e-01	2.93e-01
SUMOylation	139	3.35e-02	1.33e-01	0.12500	0.028900	1.22e-01	5.57e-01	1.36e-02
Separation-of-Sister-Chromatids	130	5.52e-02	1.88e-01	0.12500	-0.121000	3.00e-02	1.73e-02	5.56e-01
Cyclin-E-associated-events-during-G1/S-transition	73	1.69e-01	3.75e-01	0.12500	-0.122000	-2.56e-02	7.17e-02	7.06e-01
Phase-I---Functionalization-of-compounds	45	3.48e-01	5.65e-01	0.12400	0.124000	3.19e-03	1.49e-01	9.70e-01
Presynaptic-phase-of-homologous-DNA-pairing-and-strand-exchange	26	5.18e-01	7.04e-01	0.12400	0.108000	6.07e-02	3.40e-01	5.93e-01
Activation-of-ATR-in-response-to-replication-stress	27	5.60e-01	7.26e-01	0.12400	0.049700	-1.13e-01	6.55e-01	3.08e-01
Resolution-of-D-loop-Structures-through-Holliday-Junction-Intermediates	16	7.04e-01	8.28e-01	0.12400	0.119000	-3.48e-02	4.11e-01	8.09e-01
Transcriptional-Regulation-by-VENTX	33	4.42e-01	6.42e-01	0.12400	-0.114000	-4.76e-02	2.57e-01	6.36e-01
Caspase-activation-via-Death-Receptors-in-the-presence-of-ligand	12	7.79e-01	8.63e-01	0.12300	0.064000	-1.05e-01	7.01e-01	5.30e-01
Negative-epigenetic-regulation-of-rRNA-expression	48	3.08e-01	5.38e-01	0.12300	-0.054600	-1.10e-01	5.13e-01	1.88e-01
Intra-Golgi-and-retrograde-Golgi-to-ER-traffic	149	2.52e-02	1.09e-01	0.12200	0.085400	8.78e-02	7.29e-02	6.50e-02
Neurexins-and-neuroligins	29	5.54e-01	7.23e-01	0.12200	0.085400	-8.78e-02	4.26e-01	4.14e-01
Beta-catenin-independent-WNT-signaling	121	5.88e-02	1.98e-01	0.12200	-0.118000	-3.09e-02	2.52e-02	5.59e-01
Zinc-transporters	10	7.91e-01	8.70e-01	0.12200	-0.119000	-2.75e-02	5.16e-01	8.80e-01
RHO-GTPases-activate-PKNs	27	5.49e-01	7.23e-01	0.12200	0.006210	-1.22e-01	9.55e-01	2.74e-01
FOXO-mediated-transcription	51	3.24e-01	5.52e-01	0.12200	-0.005920	1.22e-01	9.42e-01	1.34e-01
Transcriptional-Regulation-by-MECP2	42	4.03e-01	6.07e-01	0.12200	-0.018100	1.20e-01	8.39e-01	1.78e-01
SUMO-E3-ligases-SUMOylate-target-proteins	134	4.45e-02	1.62e-01	0.12200	0.031000	1.18e-01	5.37e-01	1.91e-02
HDR-through-Homologous-Recombination-(HRR)-or-Single-Strand-Annealing-(SSA)	70	2.41e-01	4.72e-01	0.12200	0.061000	-1.05e-01	3.78e-01	1.29e-01
Regulation-of-TP53-Activity-through-Association-with-Co-factors	10	8.12e-01	8.85e-01	0.12100	0.045700	-1.13e-01	8.03e-01	5.38e-01
Intracellular-signaling-by-second-messengers	252	6.92e-03	4.19e-02	0.12100	-0.098800	7.03e-02	7.21e-03	5.60e-02
Negative-regulation-of-NMDA-receptor-mediated-neuronal-transmission	13	7.43e-01	8.40e-01	0.12100	-0.120000	-1.74e-02	4.54e-01	9.14e-01
Protein-protein-interactions-at-synapses	43	4.20e-01	6.24e-01	0.12100	0.103000	-6.37e-02	2.43e-01	4.70e-01
Glycosaminoglycan-metabolism	84	1.87e-01	4.00e-01	0.12100	0.101000	-6.64e-02	1.10e-01	2.94e-01
Interleukin-1-signaling	88	1.65e-01	3.70e-01	0.12100	-0.112000	4.41e-02	6.86e-02	4.75e-01
COPI-mediated-anterograde-transport	73	1.73e-01	3.80e-01	0.12100	0.099200	6.90e-02	1.43e-01	3.09e-01
DAG-and-IP3-signaling	35	4.59e-01	6.55e-01	0.12100	0.005320	1.21e-01	9.57e-01	2.17e-01
G2/M-Checkpoints	103	8.88e-02	2.58e-01	0.11900	-0.092800	-7.52e-02	1.04e-01	1.88e-01
ATF6-(ATF6-alpha)-activates-chaperones	12	7.59e-01	8.50e-01	0.11900	-0.043700	-1.11e-01	7.93e-01	5.06e-01
Toll-Like-Receptor-3-(TLR3)-Cascade	83	1.68e-01	3.74e-01	0.11900	0.004180	1.19e-01	9.48e-01	6.11e-02
RIP-mediated-NFkB-activation-via-ZBP1	16	7.07e-01	8.28e-01	0.11900	0.119000	8.32e-03	4.11e-01	9.54e-01
Processing-of-Capped-Intron-Containing-Pre-mRNA	225	6.12e-03	3.79e-02	0.11800	-0.101000	-6.21e-02	9.58e-03	1.10e-01
Signaling-by-VEGF	92	1.21e-01	3.12e-01	0.11800	-0.073700	-9.22e-02	2.23e-01	1.27e-01
SUMOylation-of-ubiquitinylation-proteins	35	4.68e-01	6.61e-01	0.11800	0.019600	1.16e-01	8.41e-01	2.34e-01
Recruitment-of-NuMA-to-mitotic-centrosomes	70	2.57e-01	4.85e-01	0.11800	0.109000	-4.36e-02	1.14e-01	5.29e-01
Regulation-of-HSF1-mediated-heat-shock-response	72	2.55e-01	4.85e-01	0.11700	-0.103000	5.67e-02	1.33e-01	4.06e-01
Interleukin-4-and-Interleukin-13-signaling	65	2.47e-01	4.79e-01	0.11700	-0.023500	-1.15e-01	7.43e-01	1.10e-01
Leishmania-infection	133	6.75e-02	2.16e-01	0.11700	0.007510	-1.17e-01	8.81e-01	2.03e-02
Formation-of-TC-NER-Pre-Incision-Complex	52	3.18e-01	5.49e-01	0.11700	-0.110000	-4.10e-02	1.72e-01	6.10e-01
Activation-of-HOX-genes-during-differentiation	47	3.87e-01	5.95e-01	0.11700	-0.116000	1.18e-02	1.68e-01	8.89e-01
Activation-of-anterior-HOX-genes-in-hindbrain-development-during-early-embryogenesis	47	3.87e-01	5.95e-01	0.11700	-0.116000	1.18e-02	1.68e-01	8.89e-01
RUNX2-regulates-bone-development	25	6.15e-01	7.72e-01	0.11700	0.111000	-3.50e-02	3.35e-01	7.62e-01
Gap-filling-DNA-repair-synthesis-and-ligation-in-GG-NER	22	6.24e-01	7.76e-01	0.11600	-0.029100	-1.13e-01	8.13e-01	3.61e-01
EML4-and-NUDC-in-mitotic-spindle-formation	64	2.80e-01	5.08e-01	0.11600	-0.008150	1.15e-01	9.10e-01	1.11e-01
Cooperation-of-PDCL-(PhLP1)-and-TRiC/CCT-in-G-protein-beta-folding	27	6.10e-01	7.67e-01	0.11500	0.098300	-6.03e-02	3.77e-01	5.88e-01
Transcriptional-regulation-by-small-RNAs	43	4.32e-01	6.33e-01	0.11500	-0.114000	1.44e-02	1.95e-01	8.71e-01
TICAM1,-RIP1-mediated-IKK-complex-recruitment	17	7.24e-01	8.34e-01	0.11400	0.023000	-1.12e-01	8.70e-01	4.24e-01
Hedgehog-'off'-state	89	1.82e-01	3.91e-01	0.11400	-0.113000	1.41e-02	6.48e-02	8.19e-01
Developmental-Biology	606	4.55e-06	1.33e-04	0.11400	-0.053500	-1.01e-01	2.64e-02	2.80e-05
Diseases-of-carbohydrate-metabolism	28	5.59e-01	7.26e-01	0.11400	0.036800	1.08e-01	7.37e-01	3.24e-01
Incretin-synthesis,-secretion,-and-inactivation	10	8.38e-01	8.98e-01	0.11400	0.090200	-6.92e-02	6.21e-01	7.05e-01
Transmission-across-Chemical-Synapses	132	6.43e-02	2.09e-01	0.11400	0.104000	4.65e-02	4.02e-02	3.57e-01
SUMOylation-of-DNA-methylation-proteins	15	7.69e-01	8.55e-01	0.11300	0.075400	-8.48e-02	6.13e-01	5.70e-01
CD28-dependent-PI3K/Akt-signaling	19	7.17e-01	8.29e-01	0.11300	-0.086200	7.38e-02	5.16e-01	5.78e-01
EGR2-and-SOX10-mediated-initiation-of-Schwann-cell-myelination	17	7.12e-01	8.28e-01	0.11300	0.112000	1.58e-02	4.23e-01	9.10e-01
Vasopressin-regulates-renal-water-homeostasis-via-Aquaporins	29	5.89e-01	7.48e-01	0.11300	0.108000	-3.55e-02	3.16e-01	7.41e-01
Amplification--of-signal-from-unattached--kinetochores-via-a-MAD2--inhibitory-signal	60	3.24e-01	5.52e-01	0.11300	-0.016200	1.12e-01	8.28e-01	1.33e-01
Amplification-of-signal-from-the-kinetochores	60	3.24e-01	5.52e-01	0.11300	-0.016200	1.12e-01	8.28e-01	1.33e-01
Calnexin/calreticulin-cycle	25	6.47e-01	7.94e-01	0.11300	-0.072500	8.67e-02	5.30e-01	4.53e-01
ER-to-Golgi-Anterograde-Transport	116	8.88e-02	2.58e-01	0.11300	0.060600	9.53e-02	2.60e-01	7.69e-02
Regulation-of-TNFR1-signaling	29	5.52e-01	7.23e-01	0.11300	-0.107000	-3.72e-02	3.21e-01	7.29e-01
Neuronal-System	189	1.94e-02	9.09e-02	0.11300	0.083800	7.55e-02	4.78e-02	7.44e-02
Defective-TPR-may-confer-susceptibility-towards-thyroid-papillary-carcinoma-(TPC)	27	6.27e-01	7.78e-01	0.11300	-0.074400	8.45e-02	5.04e-01	4.47e-01
Regulation-of-Glucokinase-by-Glucokinase-Regulatory-Protein	27	6.27e-01	7.78e-01	0.11300	-0.074400	8.45e-02	5.04e-01	4.47e-01
G-alpha-(i)-signalling-events	148	8.03e-02	2.45e-01	0.11200	0.066200	-9.06e-02	1.66e-01	5.78e-02
RHO-GTPases-Activate-WASPs-and-WAVEs	30	5.35e-01	7.14e-01	0.11200	-0.073700	-8.44e-02	4.85e-01	4.24e-01
Sialic-acid-metabolism	22	6.43e-01	7.91e-01	0.11200	-0.107000	-3.30e-02	3.85e-01	7.89e-01
Translesion-synthesis-by-POLK	15	7.33e-01	8.38e-01	0.11200	0.093300	6.19e-02	5.32e-01	6.78e-01
Glucagon-like-Peptide-1-(GLP1)-regulates-insulin-secretion	28	6.23e-01	7.75e-01	0.11200	0.082600	-7.50e-02	4.50e-01	4.93e-01
Paradoxical-activation-of-RAF-signaling-by-kinase-inactive-BRAF	38	5.23e-01	7.05e-01	0.11100	0.094600	-5.89e-02	3.13e-01	5.30e-01
Signaling-by-RAS-mutants	38	5.23e-01	7.05e-01	0.11100	0.094600	-5.89e-02	3.13e-01	5.30e-01
Signaling-by-moderate-kinase-activity-BRAF-mutants	38	5.23e-01	7.05e-01	0.11100	0.094600	-5.89e-02	3.13e-01	5.30e-01
Signaling-downstream-of-RAS-mutants	38	5.23e-01	7.05e-01	0.11100	0.094600	-5.89e-02	3.13e-01	5.30e-01
Metalloprotease-DUBs	13	8.01e-01	8.77e-01	0.11100	-0.099500	4.88e-02	5.35e-01	7.61e-01
Unblocking-of-NMDA-receptors,-glutamate-binding-and-activation	10	8.46e-01	9.03e-01	0.11100	-0.088300	6.69e-02	6.29e-01	7.14e-01
Activation-of-PPARGC1A-(PGC-1alpha)-by-phosphorylation	10	8.19e-01	8.88e-01	0.11000	0.053900	9.62e-02	7.68e-01	5.98e-01
PPARA-activates-gene-expression	102	1.62e-01	3.69e-01	0.11000	-0.010300	1.10e-01	8.57e-01	5.63e-02
Transport-of-the-SLBP-independent-Mature-mRNA	31	5.96e-01	7.54e-01	0.11000	-0.095000	5.55e-02	3.60e-01	5.93e-01
Sphingolipid-de-novo-biosynthesis	30	5.93e-01	7.52e-01	0.11000	-0.107000	2.52e-02	3.11e-01	8.12e-01
Signaling-by-FGFR3-fusions-in-cancer	10	8.49e-01	9.04e-01	0.10900	-0.086100	6.74e-02	6.37e-01	7.12e-01
Homology-Directed-Repair	76	2.79e-01	5.07e-01	0.10900	0.037400	-1.03e-01	5.74e-01	1.22e-01
WNT5A-dependent-internalization-of-FZD2,-FZD5-and-ROR2	12	8.22e-01	8.88e-01	0.10900	-0.089100	6.30e-02	5.93e-01	7.06e-01
SUMOylation-of-SUMOylation-proteins	31	5.76e-01	7.36e-01	0.10800	0.001200	1.08e-01	9.91e-01	2.96e-01
DNA-Double-Strand-Break-Response	34	5.51e-01	7.23e-01	0.10800	-0.108000	7.45e-03	2.75e-01	9.40e-01
Initiation-of-Nuclear-Envelope-(NE)-Reformation	16	7.33e-01	8.38e-01	0.10800	0.081000	7.17e-02	5.75e-01	6.20e-01
Negative-regulation-of-MAPK-pathway	35	5.52e-01	7.23e-01	0.10800	-0.106000	2.08e-02	2.78e-01	8.32e-01
TNFR1-induced-NFkappaB-signaling-pathway	23	6.89e-01	8.16e-01	0.10800	-0.049300	9.61e-02	6.82e-01	4.25e-01
Signaling-by-EGFR-in-Cancer	19	7.05e-01	8.28e-01	0.10800	-0.104000	-2.88e-02	4.34e-01	8.28e-01
EPH-ephrin-mediated-repulsion-of-cells	35	5.12e-01	6.98e-01	0.10700	-0.065400	-8.53e-02	5.04e-01	3.83e-01
TICAM1,TRAF6-dependent-induction-of-TAK1-complex	10	8.34e-01	8.96e-01	0.10700	-0.105000	-2.40e-02	5.67e-01	8.96e-01
Aquaporin-mediated-transport	30	6.09e-01	7.66e-01	0.10700	0.104000	-2.42e-02	3.23e-01	8.18e-01
Translesion-Synthesis-by-POLH	16	7.80e-01	8.63e-01	0.10700	-0.079700	7.09e-02	5.81e-01	6.24e-01
Signaling-by-SCF-KIT	36	5.69e-01	7.31e-01	0.10600	-0.096800	4.28e-02	3.15e-01	6.57e-01
Dual-Incision-in-GG-NER	38	5.54e-01	7.23e-01	0.10600	0.045200	-9.55e-02	6.30e-01	3.09e-01
Negative-regulation-of-the-PI3K/AKT-network	73	3.31e-01	5.58e-01	0.10600	-0.080100	6.89e-02	2.37e-01	3.10e-01
Biological-oxidations	100	1.65e-01	3.70e-01	0.10500	0.092300	5.03e-02	1.11e-01	3.85e-01
Regulation-of-lipid-metabolism-by-PPARalpha	104	1.84e-01	3.96e-01	0.10500	-0.010000	1.05e-01	8.60e-01	6.59e-02
HIV-Infection	202	3.53e-02	1.39e-01	0.10500	-0.105000	-4.34e-03	1.04e-02	9.16e-01
Signaling-by-Insulin-receptor	52	4.33e-01	6.34e-01	0.10500	-0.017500	1.04e-01	8.28e-01	1.97e-01
Signaling-by-Hedgehog	116	1.75e-01	3.82e-01	0.10500	-0.091400	5.10e-02	8.98e-02	3.44e-01
Kinesins	20	7.15e-01	8.28e-01	0.10400	0.104000	1.04e-02	4.22e-01	9.36e-01
GPCR-downstream-signalling	295	1.03e-02	5.68e-02	0.10400	0.015700	-1.03e-01	6.46e-01	2.51e-03
RNA-Polymerase-III-Transcription-Initiation-From-Type-3-Promoter	28	6.15e-01	7.72e-01	0.10400	-0.034700	-9.79e-02	7.51e-01	3.70e-01
Recruitment-and-ATM-mediated-phosphorylation-of-repair-and-signaling-proteins-at-DNA-double-strand-breaks	33	5.91e-01	7.50e-01	0.10400	-0.103000	1.07e-02	3.05e-01	9.15e-01
Ovarian-tumor-domain-proteases	32	5.71e-01	7.31e-01	0.10400	-0.047200	-9.22e-02	6.44e-01	3.67e-01
Cellular-responses-to-stress	435	5.80e-04	6.75e-03	0.10300	-0.064500	-8.08e-02	2.23e-02	4.15e-03
Plasma-lipoprotein-clearance	22	6.97e-01	8.25e-01	0.10300	-0.103000	-1.05e-02	4.05e-01	9.32e-01
Transcriptional-regulation-of-granulopoiesis	23	7.02e-01	8.28e-01	0.10300	0.101000	-2.16e-02	4.04e-01	8.58e-01
Transport-to-the-Golgi-and-subsequent-modification	139	9.07e-02	2.61e-01	0.10200	0.072900	7.19e-02	1.39e-01	1.45e-01
Endogenous-sterols	14	7.96e-01	8.73e-01	0.10200	-0.015600	-1.01e-01	9.20e-01	5.12e-01
Pre-NOTCH-Processing-in-Golgi	17	7.45e-01	8.40e-01	0.10200	-0.081300	-6.18e-02	5.62e-01	6.59e-01
Mitotic-Spindle-Checkpoint	75	3.21e-01	5.51e-01	0.10200	-0.013300	1.01e-01	8.43e-01	1.32e-01
Cellular-responses-to-external-stimuli	438	7.35e-04	7.89e-03	0.10100	-0.060200	-8.17e-02	3.22e-02	3.65e-03
Interactions-of-Vpr-with-host-cellular-proteins	32	6.37e-01	7.87e-01	0.10100	-0.056900	8.39e-02	5.78e-01	4.12e-01
Apoptotic-execution-phase	38	5.40e-01	7.17e-01	0.10100	-0.023900	-9.84e-02	7.99e-01	2.94e-01
DCC-mediated-attractive-signaling	13	8.15e-01	8.86e-01	0.10100	-0.100000	-1.09e-02	5.31e-01	9.46e-01
RNA-Polymerase-III-Transcription-Initiation	35	5.59e-01	7.26e-01	0.10100	-0.085900	-5.23e-02	3.79e-01	5.93e-01
PTK6-Regulates-RHO-GTPases,-RAS-GTPase-and-MAP-kinases	12	8.46e-01	9.03e-01	0.10100	0.084600	-5.43e-02	6.12e-01	7.45e-01
TP53-Regulates-Transcription-of-DNA-Repair-Genes	53	4.50e-01	6.47e-01	0.10000	0.004600	-1.00e-01	9.54e-01	2.07e-01
Degradation-of-cysteine-and-homocysteine	10	8.71e-01	9.18e-01	0.09980	-0.087900	4.72e-02	6.30e-01	7.96e-01
PI5P,-PP2A-and-IER3-Regulate-PI3K/AKT-Signaling	66	4.12e-01	6.15e-01	0.09950	-0.072700	6.79e-02	3.07e-01	3.41e-01
Regulation-of-PLK1-Activity-at-G2/M-Transition	74	3.59e-01	5.72e-01	0.09940	0.091900	-3.79e-02	1.72e-01	5.73e-01
Intra-Golgi-traffic	39	5.92e-01	7.50e-01	0.09930	-0.059800	7.93e-02	5.18e-01	3.92e-01
Resolution-of-Sister-Chromatid-Cohesion	69	3.58e-01	5.72e-01	0.09910	0.003420	9.91e-02	9.61e-01	1.55e-01
Metabolic-disorders-of-biological-oxidation-enzymes	16	8.05e-01	8.79e-01	0.09890	-0.086200	4.86e-02	5.51e-01	7.36e-01
FCERI-mediated-Ca+2-mobilization	22	7.09e-01	8.28e-01	0.09880	-0.094300	-2.94e-02	4.44e-01	8.11e-01
Gene-Silencing-by-RNA	58	4.45e-01	6.44e-01	0.09880	-0.095300	2.62e-02	2.10e-01	7.30e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-G2-Cell-Cycle-Arrest	13	8.19e-01	8.88e-01	0.09870	-0.096700	-2.00e-02	5.46e-01	9.01e-01
Metabolism-of-amino-acids-and-derivatives	251	1.95e-02	9.11e-02	0.09870	-0.049200	-8.56e-02	1.82e-01	2.02e-02
Signaling-by-Activin	10	8.70e-01	9.18e-01	0.09850	-0.026100	9.49e-02	8.86e-01	6.03e-01
Signaling-by-NTRKs	107	2.40e-01	4.71e-01	0.09840	-0.086600	4.66e-02	1.22e-01	4.05e-01
RET-signaling	31	6.43e-01	7.91e-01	0.09830	-0.097600	1.18e-02	3.47e-01	9.10e-01
TNFR1-induced-proapoptotic-signaling	12	8.43e-01	9.02e-01	0.09800	0.011400	-9.74e-02	9.46e-01	5.59e-01
Long-term-potentiation	13	8.24e-01	8.90e-01	0.09790	0.011900	9.72e-02	9.41e-01	5.44e-01
Estrogen-dependent-gene-expression	78	3.10e-01	5.39e-01	0.09780	-0.095300	-2.18e-02	1.46e-01	7.40e-01
Activation-of-SMO	14	8.32e-01	8.95e-01	0.09760	0.084900	-4.82e-02	5.82e-01	7.55e-01
G2/M-DNA-damage-checkpoint	43	5.49e-01	7.23e-01	0.09750	0.096600	-1.30e-02	2.73e-01	8.83e-01
NOTCH4-Intracellular-Domain-Regulates-Transcription	19	7.58e-01	8.50e-01	0.09730	-0.096900	-8.75e-03	4.65e-01	9.47e-01
Rev-mediated-nuclear-export-of-HIV-RNA	31	6.65e-01	8.03e-01	0.09720	-0.087300	4.26e-02	4.00e-01	6.82e-01
Cell-cell-junction-organization	25	7.14e-01	8.28e-01	0.09690	-0.093500	2.55e-02	4.19e-01	8.26e-01
Mismatch-repair-(MMR)-directed-by-MSH2:MSH3-(MutSbeta)	12	8.57e-01	9.10e-01	0.09690	0.078600	-5.66e-02	6.37e-01	7.34e-01
Regulation-of-RUNX1-Expression-and-Activity	17	7.86e-01	8.66e-01	0.09680	0.000709	-9.68e-02	9.96e-01	4.90e-01
tRNA-processing	110	2.33e-01	4.60e-01	0.09680	-0.092500	2.85e-02	9.46e-02	6.06e-01
Adaptive-Immune-System	502	2.11e-03	1.63e-02	0.09660	-0.078800	5.59e-02	2.75e-03	3.38e-02
Transport-of-Mature-Transcript-to-Cytoplasm	75	3.21e-01	5.51e-01	0.09660	-0.086400	-4.32e-02	1.96e-01	5.19e-01
Platelet-calcium-homeostasis	18	7.77e-01	8.61e-01	0.09600	-0.002310	-9.60e-02	9.86e-01	4.81e-01
Inactivation,-recovery-and-regulation-of-the-phototransduction-cascade	11	8.63e-01	9.14e-01	0.09600	-0.020000	9.39e-02	9.09e-01	5.90e-01
The-phototransduction-cascade	11	8.63e-01	9.14e-01	0.09600	-0.020000	9.39e-02	9.09e-01	5.90e-01
Deadenylation-of-mRNA	21	7.43e-01	8.40e-01	0.09560	0.011800	9.49e-02	9.26e-01	4.52e-01
Toll-Like-Receptor-4-(TLR4)-Cascade	105	2.36e-01	4.66e-01	0.09550	0.001930	9.55e-02	9.73e-01	9.16e-02
GPCR-ligand-binding	97	2.50e-01	4.81e-01	0.09520	-0.025000	-9.18e-02	6.71e-01	1.19e-01
APC/C:Cdc20-mediated-degradation-of-Cyclin-B	18	7.67e-01	8.55e-01	0.09510	-0.085600	-4.15e-02	5.30e-01	7.61e-01
Programmed-Cell-Death	144	1.20e-01	3.12e-01	0.09450	-0.070400	-6.31e-02	1.46e-01	1.93e-01
Oncogene-Induced-Senescence	28	7.12e-01	8.28e-01	0.09440	0.072900	-6.00e-02	5.04e-01	5.83e-01
SUMOylation-of-transcription-cofactors	41	5.67e-01	7.31e-01	0.09440	0.014200	9.33e-02	8.75e-01	3.02e-01
Syndecan-interactions	18	7.69e-01	8.55e-01	0.09390	-0.054300	-7.65e-02	6.90e-01	5.74e-01
Viral-Messenger-RNA-Synthesis	40	5.69e-01	7.31e-01	0.09380	-0.089000	-2.98e-02	3.30e-01	7.45e-01
Unfolded-Protein-Response-(UPR)	83	3.35e-01	5.61e-01	0.09350	-0.000585	-9.35e-02	9.93e-01	1.42e-01
Budding-and-maturation-of-HIV-virion	24	7.26e-01	8.35e-01	0.09340	-0.093200	-5.17e-03	4.29e-01	9.65e-01
Metal-ion-SLC-transporters	17	8.13e-01	8.85e-01	0.09310	-0.037600	8.52e-02	7.88e-01	5.43e-01
APC-Cdc20-mediated-degradation-of-Nek2A	20	7.51e-01	8.44e-01	0.09290	-0.074400	-5.56e-02	5.65e-01	6.67e-01
RHO-GTPase-Effectors	178	8.42e-02	2.53e-01	0.09210	-0.058500	-7.11e-02	1.80e-01	1.03e-01
Transcription-Coupled-Nucleotide-Excision-Repair-(TC-NER)	75	3.49e-01	5.65e-01	0.09210	-0.069000	-6.10e-02	3.02e-01	3.62e-01
Spry-regulation-of-FGF-signaling	15	8.13e-01	8.85e-01	0.09190	0.082400	4.06e-02	5.81e-01	7.85e-01
Regulation-of-PTEN-gene-transcription	57	4.72e-01	6.63e-01	0.09140	0.020800	8.90e-02	7.86e-01	2.45e-01
HDR-through-Homologous-Recombination-(HRR)	46	5.95e-01	7.52e-01	0.09120	0.058600	-6.98e-02	4.92e-01	4.13e-01
Stimuli-sensing-channels	47	5.37e-01	7.15e-01	0.09090	0.086400	2.83e-02	3.06e-01	7.38e-01
Alpha-protein-kinase-1-signaling-pathway	10	8.95e-01	9.31e-01	0.08990	0.073300	-5.20e-02	6.88e-01	7.76e-01
Postmitotic-nuclear-pore-complex-(NPC)-reformation	26	7.09e-01	8.28e-01	0.08970	0.046700	7.66e-02	6.81e-01	4.99e-01
Mitotic-G2-G2/M-phases	157	1.27e-01	3.25e-01	0.08940	-0.068500	-5.75e-02	1.40e-01	2.15e-01
Intraflagellar-transport	34	6.69e-01	8.03e-01	0.08940	-0.009220	8.89e-02	9.26e-01	3.70e-01
SLC-mediated-transmembrane-transport	123	2.03e-01	4.16e-01	0.08920	0.076600	4.58e-02	1.43e-01	3.82e-01
Signaling-by-WNT	209	8.45e-02	2.53e-01	0.08910	-0.089100	8.24e-05	2.70e-02	9.98e-01
TRAF6-mediated-NF-kB-activation	19	7.92e-01	8.71e-01	0.08900	0.088500	9.85e-03	5.05e-01	9.41e-01
Rab-regulation-of-trafficking	109	3.11e-01	5.39e-01	0.08880	-0.051200	7.25e-02	3.57e-01	1.92e-01
G2/M-Transition	156	1.33e-01	3.31e-01	0.08860	-0.066100	-5.90e-02	1.55e-01	2.05e-01
Resolution-of-AP-sites-via-the-multiple-nucleotide-patch-replacement-pathway	23	7.82e-01	8.64e-01	0.08850	0.052900	-7.10e-02	6.61e-01	5.56e-01
Signaling-by-Receptor-Tyrosine-Kinases	370	9.56e-03	5.38e-02	0.08840	-0.071800	-5.17e-02	1.86e-02	9.02e-02
FOXO-mediated-transcription-of-cell-cycle-genes	15	8.25e-01	8.90e-01	0.08840	0.043400	7.70e-02	7.71e-01	6.06e-01
Interactions-of-Rev-with-host-cellular-proteins	32	7.15e-01	8.28e-01	0.08790	-0.063800	6.05e-02	5.33e-01	5.54e-01
Downregulation-of-TGF-beta-receptor-signaling	25	7.31e-01	8.38e-01	0.08790	-0.080000	-3.63e-02	4.89e-01	7.53e-01
Cytochrome-P450---arranged-by-substrate-type	20	8.05e-01	8.79e-01	0.08750	0.082700	-2.86e-02	5.22e-01	8.25e-01
Regulation-of-glycolysis-by-fructose-2,6-bisphosphate-metabolism	11	8.84e-01	9.25e-01	0.08740	-0.014500	8.62e-02	9.34e-01	6.21e-01
Mitotic-Prophase	71	4.46e-01	6.44e-01	0.08670	0.002190	8.67e-02	9.75e-01	2.07e-01
Membrane-Trafficking	490	3.35e-03	2.40e-02	0.08660	0.031200	8.08e-02	2.42e-01	2.41e-03
Mitotic-Anaphase	178	1.32e-01	3.29e-01	0.08660	-0.086200	-8.18e-03	4.81e-02	8.51e-01
Mitotic-Metaphase-and-Anaphase	178	1.32e-01	3.29e-01	0.08660	-0.086200	-8.18e-03	4.81e-02	8.51e-01
p75-NTR-receptor-mediated-signalling	80	4.37e-01	6.38e-01	0.08610	0.033700	-7.92e-02	6.02e-01	2.22e-01
Regulation-of-TP53-Activity-through-Acetylation	29	7.11e-01	8.28e-01	0.08590	0.023900	8.25e-02	8.24e-01	4.42e-01
Recycling-pathway-of-L1	24	7.46e-01	8.40e-01	0.08580	-0.053200	-6.73e-02	6.52e-01	5.68e-01
Toll-like-Receptor-Cascades	119	2.56e-01	4.85e-01	0.08580	0.015900	8.43e-02	7.65e-01	1.13e-01
TP53-Regulates-Metabolic-Genes	78	4.31e-01	6.33e-01	0.08530	-0.085100	6.48e-03	1.95e-01	9.21e-01
Signaling-by-TGF-beta-Receptor-Complex	67	5.15e-01	7.00e-01	0.08510	-0.070900	4.71e-02	3.16e-01	5.05e-01
Neurotransmitter-receptors-and-postsynaptic-signal-transmission	100	3.09e-01	5.38e-01	0.08500	0.075800	3.85e-02	1.91e-01	5.06e-01
Chaperonin-mediated-protein-folding	68	4.95e-01	6.85e-01	0.08500	0.022600	-8.20e-02	7.48e-01	2.43e-01
Signaling-by-NOTCH1	67	4.79e-01	6.70e-01	0.08470	-0.006740	-8.44e-02	9.24e-01	2.33e-01
Diseases-associated-with-the-TLR-signaling-cascade	18	8.21e-01	8.88e-01	0.08460	0.084400	6.12e-03	5.36e-01	9.64e-01
Diseases-of-Immune-System	18	8.21e-01	8.88e-01	0.08460	0.084400	6.12e-03	5.36e-01	9.64e-01
Ephrin-signaling	13	8.70e-01	9.18e-01	0.08460	-0.084400	5.00e-03	5.98e-01	9.75e-01
Apoptosis	141	1.91e-01	4.05e-01	0.08450	-0.065900	-5.28e-02	1.78e-01	2.80e-01
Diseases-of-signal-transduction-by-growth-factor-receptors-and-second-messengers	310	4.80e-02	1.71e-01	0.08450	-0.078300	3.15e-02	1.84e-02	3.42e-01
L1CAM-interactions	70	4.95e-01	6.85e-01	0.08440	-0.079400	2.85e-02	2.51e-01	6.80e-01
HDACs-deacetylate-histones	31	7.05e-01	8.28e-01	0.08440	0.022100	8.14e-02	8.31e-01	4.33e-01
Nuclear-Envelope-Breakdown	44	6.52e-01	7.97e-01	0.08420	-0.045900	7.06e-02	5.98e-01	4.19e-01
Cilium-Assembly	158	1.73e-01	3.80e-01	0.08420	0.081300	2.19e-02	7.88e-02	6.36e-01
Protein-folding	73	4.98e-01	6.87e-01	0.08370	0.049200	-6.78e-02	4.68e-01	3.17e-01
Formation-of-RNA-Pol-II-elongation-complex	53	5.53e-01	7.23e-01	0.08360	-0.079300	-2.65e-02	3.18e-01	7.39e-01
RNA-Polymerase-II-Transcription-Elongation	53	5.53e-01	7.23e-01	0.08360	-0.079300	-2.65e-02	3.18e-01	7.39e-01
Signaling-by-FGFR1	34	7.27e-01	8.35e-01	0.08260	-0.043800	7.00e-02	6.59e-01	4.80e-01
Post-translational-protein-modification	1020	8.31e-05	1.53e-03	0.08230	-0.008060	8.19e-02	6.70e-01	1.46e-05
IRAK2-mediated-activation-of-TAK1-complex-upon-TLR7/8-or-9-stimulation	12	8.79e-01	9.21e-01	0.08200	-0.078700	-2.32e-02	6.37e-01	8.90e-01
TRAF6-mediated-induction-of-TAK1-complex-within-TLR4-complex	12	8.79e-01	9.21e-01	0.08200	-0.078700	-2.32e-02	6.37e-01	8.90e-01
Gamma-carboxylation,-hypusine-formation-and-arylsulfatase-activation	23	8.02e-01	8.77e-01	0.08180	-0.022100	7.88e-02	8.55e-01	5.13e-01
IRF3-mediated-induction-of-type-I-IFN	10	9.11e-01	9.40e-01	0.08170	0.035800	-7.34e-02	8.44e-01	6.88e-01
tRNA-processing-in-the-nucleus	53	5.60e-01	7.26e-01	0.08150	-0.067900	-4.50e-02	3.93e-01	5.71e-01
Constitutive-Signaling-by-EGFRvIII	15	8.50e-01	9.04e-01	0.08130	0.036200	7.28e-02	8.08e-01	6.25e-01
Signaling-by-EGFRvIII-in-Cancer	15	8.50e-01	9.04e-01	0.08130	0.036200	7.28e-02	8.08e-01	6.25e-01
Activation-of-AMPK-downstream-of-NMDARs	10	9.13e-01	9.41e-01	0.08080	0.033600	-7.34e-02	8.54e-01	6.88e-01
Mitotic-G1-phase-and-G1/S-transition	118	2.83e-01	5.10e-01	0.08070	-0.049200	-6.40e-02	3.57e-01	2.31e-01
HIV-Transcription-Initiation	44	6.74e-01	8.03e-01	0.08070	0.040100	-7.00e-02	6.46e-01	4.22e-01
RNA-Polymerase-II-HIV-Promoter-Escape	44	6.74e-01	8.03e-01	0.08070	0.040100	-7.00e-02	6.46e-01	4.22e-01
RNA-Polymerase-II-Promoter-Escape	44	6.74e-01	8.03e-01	0.08070	0.040100	-7.00e-02	6.46e-01	4.22e-01
RNA-Polymerase-II-Transcription-Initiation	44	6.74e-01	8.03e-01	0.08070	0.040100	-7.00e-02	6.46e-01	4.22e-01
RNA-Polymerase-II-Transcription-Initiation-And-Promoter-Clearance	44	6.74e-01	8.03e-01	0.08070	0.040100	-7.00e-02	6.46e-01	4.22e-01
RNA-Polymerase-II-Transcription-Pre-Initiation-And-Promoter-Opening	44	6.74e-01	8.03e-01	0.08070	0.040100	-7.00e-02	6.46e-01	4.22e-01
Transport-of-Mature-mRNA-derived-from-an-Intron-Containing-Transcript	67	4.89e-01	6.81e-01	0.08040	-0.063900	-4.88e-02	3.67e-01	4.90e-01
Transport-of-the-SLBP-Dependant-Mature-mRNA	32	7.54e-01	8.46e-01	0.08030	-0.064700	4.77e-02	5.27e-01	6.41e-01
Ion-channel-transport	99	3.59e-01	5.72e-01	0.08030	0.074800	2.92e-02	1.99e-01	6.17e-01
Signaling-by-EGFR	41	6.78e-01	8.07e-01	0.08010	-0.079600	9.23e-03	3.78e-01	9.19e-01
RAB-GEFs-exchange-GTP-for-GDP-on-RABs	80	5.00e-01	6.89e-01	0.07990	-0.062300	5.01e-02	3.36e-01	4.39e-01
Transcriptional-regulation-of-white-adipocyte-differentiation	72	5.38e-01	7.16e-01	0.07970	0.057100	-5.56e-02	4.03e-01	4.15e-01
Signaling-by-FGFR	61	5.33e-01	7.12e-01	0.07970	-0.035200	-7.15e-02	6.35e-01	3.35e-01
Glycolysis	58	6.08e-01	7.66e-01	0.07950	-0.060000	5.22e-02	4.30e-01	4.92e-01
Signaling-by-BRAF-and-RAF-fusions	55	5.66e-01	7.31e-01	0.07950	0.068500	4.03e-02	3.80e-01	6.05e-01
ECM-proteoglycans	35	6.99e-01	8.27e-01	0.07950	-0.030500	-7.34e-02	7.55e-01	4.53e-01
BBSome-mediated-cargo-targeting-to-cilium	18	8.30e-01	8.94e-01	0.07890	-0.060900	-5.02e-02	6.55e-01	7.13e-01
Inositol-phosphate-metabolism	39	6.73e-01	8.03e-01	0.07880	0.069900	3.64e-02	4.51e-01	6.94e-01
DNA-Repair	234	1.09e-01	2.94e-01	0.07870	-0.077600	-1.28e-02	4.17e-02	7.36e-01
RUNX1-interacts-with-co-factors-whose-precise-effect-on-RUNX1-targets-is-not-known	36	7.34e-01	8.39e-01	0.07800	-0.027500	7.30e-02	7.76e-01	4.49e-01
HS-GAG-biosynthesis	18	8.35e-01	8.96e-01	0.07780	-0.061700	-4.73e-02	6.50e-01	7.28e-01
Nuclear-Events-(kinase-and-transcription-factor-activation)	47	6.80e-01	8.08e-01	0.07770	-0.056400	5.34e-02	5.04e-01	5.26e-01
NOTCH3-Intracellular-Domain-Regulates-Transcription	19	8.48e-01	9.04e-01	0.07750	-0.075500	1.77e-02	5.69e-01	8.94e-01
Netrin-1-signaling	35	7.06e-01	8.28e-01	0.07740	-0.059100	-4.99e-02	5.45e-01	6.10e-01
IKK-complex-recruitment-mediated-by-RIP1	18	8.41e-01	9.01e-01	0.07730	-0.027900	-7.21e-02	8.38e-01	5.97e-01
Transport-of-small-molecules	431	3.05e-02	1.26e-01	0.07720	-0.028600	7.17e-02	3.12e-01	1.14e-02
Organelle-biogenesis-and-maintenance	229	1.36e-01	3.31e-01	0.07680	-0.001270	7.68e-02	9.74e-01	4.63e-02
FCERI-mediated-MAPK-activation	25	7.97e-01	8.74e-01	0.07670	0.007340	7.63e-02	9.49e-01	5.09e-01
Cargo-recognition-for-clathrin-mediated-endocytosis	76	5.44e-01	7.21e-01	0.07650	-0.041700	6.41e-02	5.30e-01	3.34e-01
Signaling-by-GPCR	316	7.90e-02	2.43e-01	0.07580	0.020400	-7.30e-02	5.35e-01	2.66e-02
TP53-Regulates-Transcription-of-Cell-Cycle-Genes	36	7.38e-01	8.40e-01	0.07550	0.007120	-7.51e-02	9.41e-01	4.36e-01
Translesion-synthesis-by-POLI	14	8.79e-01	9.21e-01	0.07460	0.042700	6.12e-02	7.82e-01	6.92e-01
Translesion-synthesis-by-REV1	14	8.79e-01	9.21e-01	0.07460	0.042700	6.12e-02	7.82e-01	6.92e-01
SUMOylation-of-DNA-replication-proteins	37	7.14e-01	8.28e-01	0.07440	0.063900	3.81e-02	5.02e-01	6.89e-01
Senescence-Associated-Secretory-Phenotype-(SASP)	41	7.33e-01	8.38e-01	0.07420	0.037500	-6.41e-02	6.78e-01	4.78e-01
G1/S-Transition	105	3.92e-01	6.01e-01	0.07350	-0.046500	-5.69e-02	4.11e-01	3.15e-01
Nucleotide-Excision-Repair	106	3.90e-01	5.99e-01	0.07350	-0.060400	-4.19e-02	2.84e-01	4.57e-01
Post-translational-modification:-synthesis-of-GPI-anchored-proteins	43	7.02e-01	8.28e-01	0.07330	-0.005400	-7.31e-02	9.51e-01	4.07e-01
MET-promotes-cell-motility	23	8.46e-01	9.03e-01	0.07300	-0.043500	5.86e-02	7.18e-01	6.27e-01
Signaling-by-NTRK1-(TRKA)	93	5.01e-01	6.90e-01	0.07300	-0.066900	2.92e-02	2.66e-01	6.27e-01
Regulation-of-TP53-Degradation	31	7.70e-01	8.55e-01	0.07200	-0.031200	-6.49e-02	7.64e-01	5.32e-01
Regulation-of-TP53-Expression-and-Degradation	31	7.70e-01	8.55e-01	0.07200	-0.031200	-6.49e-02	7.64e-01	5.32e-01
Transport-of-inorganic-cations/anions-and-amino-acids/oligopeptides	56	6.60e-01	8.03e-01	0.07200	0.069400	-1.89e-02	3.69e-01	8.07e-01
Mitotic-Prometaphase	140	3.27e-01	5.55e-01	0.07180	0.070700	1.28e-02	1.50e-01	7.95e-01
Ion-transport-by-P-type-ATPases	36	7.40e-01	8.40e-01	0.07160	0.063600	3.29e-02	5.10e-01	7.33e-01
Metabolism-of-vitamins-and-cofactors	132	3.44e-01	5.64e-01	0.07120	0.024300	6.69e-02	6.31e-01	1.86e-01
Cytokine-Signaling-in-Immune-system	541	1.30e-02	6.75e-02	0.07100	-0.049100	-5.14e-02	5.34e-02	4.32e-02
Antigen-Presentation:-Folding,-assembly-and-peptide-loading-of-class-I-MHC	17	8.73e-01	9.19e-01	0.06940	0.047900	5.03e-02	7.33e-01	7.20e-01
Signaling-by-FGFR-in-disease	49	7.26e-01	8.35e-01	0.06930	-0.042300	5.49e-02	6.09e-01	5.07e-01
Asparagine-N-linked-glycosylation	241	1.56e-01	3.62e-01	0.06920	0.060800	3.30e-02	1.05e-01	3.79e-01
Cargo-trafficking-to-the-periciliary-membrane	42	7.49e-01	8.42e-01	0.06900	-0.014000	6.75e-02	8.75e-01	4.49e-01
Signaling-by-FGFR2	55	6.48e-01	7.94e-01	0.06890	-0.047800	-4.96e-02	5.40e-01	5.25e-01
Constitutive-Signaling-by-NOTCH1-HD+PEST-Domain-Mutants	55	6.64e-01	8.03e-01	0.06800	-0.063500	-2.44e-02	4.16e-01	7.55e-01
Constitutive-Signaling-by-NOTCH1-PEST-Domain-Mutants	55	6.64e-01	8.03e-01	0.06800	-0.063500	-2.44e-02	4.16e-01	7.55e-01
Signaling-by-NOTCH1-HD+PEST-Domain-Mutants-in-Cancer	55	6.64e-01	8.03e-01	0.06800	-0.063500	-2.44e-02	4.16e-01	7.55e-01
Signaling-by-NOTCH1-PEST-Domain-Mutants-in-Cancer	55	6.64e-01	8.03e-01	0.06800	-0.063500	-2.44e-02	4.16e-01	7.55e-01
Signaling-by-NOTCH1-in-Cancer	55	6.64e-01	8.03e-01	0.06800	-0.063500	-2.44e-02	4.16e-01	7.55e-01
Translesion-synthesis-by-Y-family-DNA-polymerases-bypasses-lesions-on-DNA-template	33	7.78e-01	8.61e-01	0.06780	-0.052500	-4.29e-02	6.02e-01	6.70e-01
CTLA4-inhibitory-signaling	18	8.75e-01	9.20e-01	0.06680	-0.045200	-4.93e-02	7.40e-01	7.18e-01
Chromosome-Maintenance	46	7.40e-01	8.40e-01	0.06630	0.004180	-6.62e-02	9.61e-01	4.38e-01
Costimulation-by-the-CD28-family	46	7.54e-01	8.46e-01	0.06510	-0.063800	1.33e-02	4.55e-01	8.76e-01
FCGR3A-mediated-IL10-synthesis	29	8.43e-01	9.02e-01	0.06510	0.030700	-5.74e-02	7.75e-01	5.93e-01
Diseases-associated-with-N-glycosylation-of-proteins	16	9.14e-01	9.41e-01	0.06440	0.044400	-4.67e-02	7.59e-01	7.46e-01
ESR-mediated-signaling	134	4.22e-01	6.26e-01	0.06310	-0.028600	-5.62e-02	5.69e-01	2.62e-01
Signaling-by-NTRK2-(TRKB)	20	8.97e-01	9.31e-01	0.06290	-0.031700	5.43e-02	8.06e-01	6.74e-01
Nuclear-signaling-by-ERBB4	23	8.84e-01	9.25e-01	0.06280	0.046300	-4.25e-02	7.01e-01	7.24e-01
Signaling-by-TGF-beta-family-members	83	6.42e-01	7.91e-01	0.06270	-0.049700	3.82e-02	4.35e-01	5.48e-01
NOTCH1-Intracellular-Domain-Regulates-Transcription	45	7.61e-01	8.50e-01	0.06180	0.018200	5.90e-02	8.33e-01	4.94e-01
Vesicle-mediated-transport	515	5.01e-02	1.76e-01	0.06170	0.017400	5.92e-02	5.02e-01	2.29e-02
Innate-Immune-System	661	2.23e-02	9.99e-02	0.06160	-0.018600	-5.88e-02	4.20e-01	1.10e-02
Neutrophil-degranulation	322	1.81e-01	3.91e-01	0.06050	0.005210	-6.03e-02	8.73e-01	6.45e-02
Cellular-Senescence	112	5.10e-01	6.98e-01	0.06040	0.036400	4.82e-02	5.06e-01	3.79e-01
SUMOylation-of-RNA-binding-proteins	43	7.72e-01	8.56e-01	0.06040	0.049500	3.46e-02	5.74e-01	6.95e-01
Activation-of-BAD-and-translocation-to-mitochondria	12	9.30e-01	9.51e-01	0.06040	-0.044500	-4.08e-02	7.90e-01	8.07e-01
Constitutive-Signaling-by-Ligand-Responsive-EGFR-Cancer-Variants	18	8.99e-01	9.32e-01	0.06020	-0.054300	-2.61e-02	6.90e-01	8.48e-01
Signaling-by-Ligand-Responsive-EGFR-Variants-in-Cancer	18	8.99e-01	9.32e-01	0.06020	-0.054300	-2.61e-02	6.90e-01	8.48e-01
Gene-expression-(Transcription)	975	1.26e-02	6.62e-02	0.05930	-0.052600	2.74e-02	6.45e-03	1.55e-01
Depolymerisation-of-the-Nuclear-Lamina	12	9.34e-01	9.54e-01	0.05870	-0.046500	-3.58e-02	7.80e-01	8.30e-01
Deregulated-CDK5-triggers-multiple-neurodegenerative-pathways-in-Alzheimer's-disease-models	18	9.04e-01	9.35e-01	0.05820	0.044600	3.74e-02	7.43e-01	7.84e-01
Neurodegenerative-Diseases	18	9.04e-01	9.35e-01	0.05820	0.044600	3.74e-02	7.43e-01	7.84e-01
Recognition-of-DNA-damage-by-PCNA-containing-replication-complex	25	8.91e-01	9.29e-01	0.05790	0.028200	-5.06e-02	8.07e-01	6.62e-01
Inhibition-of-replication-initiation-of-damaged-DNA-by-RB1/E2F1	10	9.54e-01	9.68e-01	0.05760	0.019500	-5.42e-02	9.15e-01	7.66e-01
DDX58/IFIH1-mediated-induction-of-interferon-alpha/beta	54	7.45e-01	8.40e-01	0.05730	-0.040300	-4.08e-02	6.09e-01	6.04e-01
RAF-activation	30	8.67e-01	9.17e-01	0.05720	-0.010700	5.62e-02	9.20e-01	5.95e-01
RHO-GTPases-Activate-Formins	83	6.66e-01	8.03e-01	0.05710	-0.057100	2.20e-04	3.69e-01	9.97e-01
Signaling-by-ERBB2	41	8.17e-01	8.88e-01	0.05690	-0.002270	-5.68e-02	9.80e-01	5.29e-01
Rho-GTPase-cycle	111	6.14e-01	7.72e-01	0.05660	0.049300	-2.78e-02	3.71e-01	6.14e-01
Interferon-gamma-signaling	51	7.90e-01	8.70e-01	0.05600	0.006760	-5.56e-02	9.33e-01	4.92e-01
Signalling-to-ERKs	30	8.63e-01	9.14e-01	0.05530	0.051900	1.91e-02	6.23e-01	8.57e-01
Phosphorylation-of-the-APC/C	15	9.35e-01	9.55e-01	0.05440	-0.001400	5.44e-02	9.93e-01	7.15e-01
Regulation-of-TP53-Activity	131	5.68e-01	7.31e-01	0.05440	-0.006680	5.39e-02	8.95e-01	2.88e-01
VEGFA-VEGFR2-Pathway	83	6.72e-01	8.03e-01	0.05390	-0.032100	-4.33e-02	6.14e-01	4.96e-01
Muscle-contraction	126	5.56e-01	7.25e-01	0.05350	0.046300	2.67e-02	3.70e-01	6.06e-01
DNA-Double-Strand-Break-Repair	102	6.40e-01	7.89e-01	0.05310	-0.008850	-5.23e-02	8.77e-01	3.62e-01
Insulin-receptor-recycling	19	9.26e-01	9.48e-01	0.05310	0.051100	-1.45e-02	7.00e-01	9.13e-01
E2F-mediated-regulation-of-DNA-replication	16	9.29e-01	9.50e-01	0.05270	0.042200	3.16e-02	7.70e-01	8.27e-01
Iron-uptake-and-transport	43	8.30e-01	8.94e-01	0.05260	0.010200	5.16e-02	9.08e-01	5.59e-01
CLEC7A-(Dectin-1)-induces-NFAT-activation	11	9.59e-01	9.72e-01	0.05250	-0.022800	4.74e-02	8.96e-01	7.86e-01
S-Phase	134	5.59e-01	7.26e-01	0.05140	-0.040200	-3.20e-02	4.23e-01	5.23e-01
HDR-through-Single-Strand-Annealing-(SSA)	28	8.92e-01	9.30e-01	0.05100	0.050200	9.00e-03	6.46e-01	9.34e-01
Metabolism	1462	5.62e-03	3.63e-02	0.05040	0.012900	4.87e-02	4.25e-01	2.50e-03
SLC-transporter-disorders	55	7.94e-01	8.71e-01	0.05040	0.040300	3.03e-02	6.06e-01	6.98e-01
Cell-Cycle-Checkpoints	185	5.07e-01	6.94e-01	0.04910	-0.048800	-5.25e-03	2.54e-01	9.02e-01
Metabolism-of-carbohydrates	210	4.64e-01	6.58e-01	0.04890	0.006780	4.84e-02	8.66e-01	2.28e-01
SMAD2/SMAD3:SMAD4-heterotrimer-regulates-transcription	28	9.11e-01	9.40e-01	0.04810	0.046900	-1.05e-02	6.68e-01	9.23e-01
Signaling-by-Rho-GTPases	280	3.73e-01	5.85e-01	0.04770	-0.010900	-4.65e-02	7.55e-01	1.83e-01
Interleukin-1-family-signaling	108	7.21e-01	8.33e-01	0.04720	-0.039700	2.55e-02	4.77e-01	6.48e-01
Nuclear-Envelope-(NE)-Reassembly	61	8.32e-01	8.95e-01	0.04630	0.017400	-4.29e-02	8.14e-01	5.62e-01
Conversion-from-APC/C:Cdc20-to-APC/C:Cdh1-in-late-anaphase	17	9.41e-01	9.59e-01	0.04630	0.029700	3.55e-02	8.32e-01	8.00e-01
Clathrin-mediated-endocytosis	110	7.23e-01	8.34e-01	0.04610	-0.042200	1.86e-02	4.46e-01	7.37e-01
CD28-co-stimulation	27	9.24e-01	9.48e-01	0.04600	-0.022200	4.03e-02	8.42e-01	7.17e-01
Diseases-of-programmed-cell-death	19	9.44e-01	9.60e-01	0.04420	0.043800	6.01e-03	7.41e-01	9.64e-01
Disease	951	6.37e-02	2.08e-01	0.04350	-0.026900	-3.42e-02	1.68e-01	7.97e-02
Signal-Transduction	1460	1.80e-02	8.56e-02	0.04340	-0.031900	-2.94e-02	4.80e-02	6.81e-02
Generic-Transcription-Pathway	753	1.65e-01	3.70e-01	0.04320	-0.033300	2.76e-02	1.26e-01	2.05e-01
RNA-polymerase-II-transcribes-snRNA-genes	68	8.21e-01	8.88e-01	0.04310	-0.042300	-8.02e-03	5.47e-01	9.09e-01
Immune-System	1299	3.19e-02	1.30e-01	0.04230	-0.033600	-2.57e-02	4.75e-02	1.30e-01
RNA-Polymerase-II-Transcription	864	1.50e-01	3.51e-01	0.04150	-0.034300	2.34e-02	9.26e-02	2.52e-01
Formation-of-Incision-Complex-in-GG-NER	41	9.08e-01	9.39e-01	0.04060	0.038700	-1.22e-02	6.68e-01	8.92e-01
Late-Phase-of-HIV-Life-Cycle	121	7.40e-01	8.40e-01	0.04000	-0.039400	-7.18e-03	4.56e-01	8.92e-01
Signaling-by-Interleukins	301	4.69e-01	6.61e-01	0.03940	-0.023900	-3.14e-02	4.79e-01	3.52e-01
Interleukin-10-signaling	12	9.74e-01	9.80e-01	0.03930	0.009710	-3.81e-02	9.54e-01	8.19e-01
Oncogenic-MAPK-signaling	62	8.68e-01	9.17e-01	0.03870	0.038700	1.86e-03	5.99e-01	9.80e-01
Signaling-by-Non-Receptor-Tyrosine-Kinases	43	9.24e-01	9.48e-01	0.03660	0.028800	-2.27e-02	7.44e-01	7.97e-01
Signaling-by-PTK6	43	9.24e-01	9.48e-01	0.03660	0.028800	-2.27e-02	7.44e-01	7.97e-01
G-alpha-(12/13)-signalling-events	60	8.94e-01	9.30e-01	0.03600	0.007710	-3.51e-02	9.18e-01	6.38e-01
Transferrin-endocytosis-and-recycling	22	9.60e-01	9.72e-01	0.03570	0.035300	-5.58e-03	7.75e-01	9.64e-01
M-Phase	280	6.21e-01	7.75e-01	0.03520	-0.032200	1.44e-02	3.57e-01	6.81e-01
DAP12-signaling	19	9.70e-01	9.78e-01	0.03410	0.021300	-2.66e-02	8.73e-01	8.41e-01
Cell-death-signalling-via-NRAGE,-NRIF-and-NADE	64	9.01e-01	9.34e-01	0.03400	0.012100	-3.17e-02	8.67e-01	6.61e-01
Diseases-of-metabolism	167	7.86e-01	8.66e-01	0.03270	0.021800	-2.44e-02	6.28e-01	5.87e-01
ERCC6-(CSB)-and-EHMT2-(G9a)-positively-regulate-rRNA-expression	15	9.75e-01	9.81e-01	0.03260	-0.032000	-6.55e-03	8.30e-01	9.65e-01
Transcription-of-the-HIV-genome	63	9.14e-01	9.41e-01	0.03200	0.012400	-2.95e-02	8.65e-01	6.86e-01
XBP1(S)-activates-chaperone-genes	46	9.37e-01	9.56e-01	0.03180	0.028500	-1.40e-02	7.38e-01	8.70e-01
Regulation-of-TP53-Activity-through-Phosphorylation	73	8.87e-01	9.26e-01	0.03150	0.021900	2.27e-02	7.47e-01	7.38e-01
Keratan-sulfate/keratin-metabolism	23	9.69e-01	9.78e-01	0.03070	-0.029700	7.92e-03	8.06e-01	9.48e-01
Downstream-signal-transduction	28	9.63e-01	9.74e-01	0.02990	0.029900	-1.21e-04	7.85e-01	9.99e-01
NGF-stimulated-transcription	26	9.69e-01	9.78e-01	0.02960	-0.025200	1.57e-02	8.24e-01	8.90e-01
Amino-acids-regulate-mTORC1	47	9.48e-01	9.63e-01	0.02840	-0.026500	1.03e-02	7.53e-01	9.03e-01
RNA-Polymerase-II-Pre-transcription-Events	73	9.26e-01	9.48e-01	0.02790	-0.022600	1.63e-02	7.39e-01	8.10e-01
Metabolism-of-proteins	1475	2.42e-01	4.72e-01	0.02760	-0.026700	7.32e-03	9.70e-02	6.49e-01
Death-Receptor-Signalling	116	8.87e-01	9.26e-01	0.02760	0.022900	-1.54e-02	6.71e-01	7.75e-01
Signaling-by-MET	54	9.47e-01	9.62e-01	0.02720	-0.016700	2.15e-02	8.32e-01	7.85e-01
Metabolism-of-nucleotides	75	9.22e-01	9.48e-01	0.02690	0.000740	-2.69e-02	9.91e-01	6.87e-01
Detoxification-of-Reactive-Oxygen-Species	30	9.70e-01	9.78e-01	0.02690	0.013400	-2.33e-02	8.99e-01	8.25e-01
Inactivation-of-APC/C-via-direct-inhibition-of-the-APC/C-complex	17	9.82e-01	9.85e-01	0.02660	0.001850	2.65e-02	9.89e-01	8.50e-01
Inhibition-of-the-proteolytic-activity-of-APC/C-required-for-the-onset-of-anaphase-by-mitotic-spindle-checkpoint-components	17	9.82e-01	9.85e-01	0.02660	0.001850	2.65e-02	9.89e-01	8.50e-01
HIV-Life-Cycle	132	8.78e-01	9.21e-01	0.02620	-0.025700	5.18e-03	6.12e-01	9.18e-01
Transcriptional-Regulation-by-TP53	297	8.06e-01	8.80e-01	0.02230	-0.022200	1.32e-03	5.12e-01	9.69e-01
Global-Genome-Nucleotide-Excision-Repair-(GG-NER)	80	9.42e-01	9.59e-01	0.02120	-0.015600	-1.44e-02	8.10e-01	8.24e-01
Signaling-by-Nuclear-Receptors	186	8.94e-01	9.30e-01	0.02030	-0.002640	2.02e-02	9.51e-01	6.36e-01
IRE1alpha-activates-chaperones	48	9.70e-01	9.78e-01	0.02000	0.018600	7.10e-03	8.23e-01	9.32e-01
NRAGE-signals-death-through-JNK	48	9.80e-01	9.85e-01	0.01750	-0.009800	1.45e-02	9.07e-01	8.62e-01
DAP12-interactions	20	9.92e-01	9.94e-01	0.01700	0.007490	-1.53e-02	9.54e-01	9.06e-01
DNA-Damage-Bypass	40	9.84e-01	9.86e-01	0.01600	-0.015600	-3.38e-03	8.64e-01	9.70e-01
Cell-Cycle	452	8.66e-01	9.17e-01	0.01460	-0.001620	-1.45e-02	9.53e-01	6.00e-01
Cell-Cycle,-Mitotic	384	9.60e-01	9.72e-01	0.00815	-0.005760	-5.77e-03	8.48e-01	8.47e-01
Signaling-by-ERBB4	41	9.99e-01	9.99e-01	0.00417	0.002390	3.42e-03	9.79e-01	9.70e-01
Negative-regulators-of-DDX58/IFIH1-signaling	31	9.99e-01	9.99e-01	0.00385	-0.001220	3.65e-03	9.91e-01	9.72e-01

---

Detailed Gene set reports

PI-3K-cascade:FGFR2

metric	value
setSize	10
pMANOVA	0.00114
p.adjustMANOVA	0.0105
s.dist	0.696
s.ab	-0.284
s.d36	0.635
p.ab	0.119
p.d36	0.00051

Gene	ab	d36
Fgf1	-3926.5	5665
Fgf16	-4034.5	5094
Fgf9	-5772.5	3111
Gab1	-3225.5	4420
Pik3r1	-2910.5	4811
Frs2	-4622.5	229
Pik3ca	-75.5	473

Click HERE to show all gene set members

	ab	d36
Fgf1	-3926.5	5665
Fgf16	-4034.5	5094
Fgf2	165.5	5279
Fgf9	-5772.5	3111
Frs2	-4622.5	229
Gab1	-3225.5	4420
Grb2	4354.5	5789
Pik3ca	-75.5	473
Pik3r1	-2910.5	4811
Ptpn11	1827.5	1935

---

---

PI-3K-cascade:FGFR4

metric	value
setSize	10
pMANOVA	0.00114
p.adjustMANOVA	0.0105
s.dist	0.696
s.ab	-0.284
s.d36	0.635
p.ab	0.119
p.d36	0.00051

Gene	ab	d36
Fgf1	-3926.5	5665
Fgf16	-4034.5	5094
Fgf9	-5772.5	3111
Gab1	-3225.5	4420
Pik3r1	-2910.5	4811
Frs2	-4622.5	229
Pik3ca	-75.5	473

Click HERE to show all gene set members

	ab	d36
Fgf1	-3926.5	5665
Fgf16	-4034.5	5094
Fgf2	165.5	5279
Fgf9	-5772.5	3111
Frs2	-4622.5	229
Gab1	-3225.5	4420
Grb2	4354.5	5789
Pik3ca	-75.5	473
Pik3r1	-2910.5	4811
Ptpn11	1827.5	1935

---

---

Regulation-of-pyruvate-dehydrogenase-(PDH)-complex

metric	value
setSize	15
pMANOVA	4.78e-05
p.adjustMANOVA	0.000951
s.dist	0.677
s.ab	-0.158
s.d36	0.659
p.ab	0.288
p.d36	1e-05

Gene	ab	d36
Rxra	-5660.5	4852
Pdk2	-4667.5	5542
Pdp1	-3944.5	5660
Ppard	-3952.5	3976
Pdk4	-2607.5	5541
Pdp2	-2320.5	5623
Dlat	-1788.5	3921
Pdha1	-1301.5	4866
Pdpr	-1393.5	3743
Pdk1	-838.5	4653
Dld	-74.5	4418
Pdhb	-242.5	1105

Click HERE to show all gene set members

	ab	d36
Dlat	-1788.5	3921
Dld	-74.5	4418
Gstz1	4779.5	2839
Pdha1	-1301.5	4866
Pdhb	-242.5	1105
Pdhx	2159.5	1148
Pdk1	-838.5	4653
Pdk2	-4667.5	5542
Pdk3	5741.5	-572
Pdk4	-2607.5	5541
Pdp1	-3944.5	5660
Pdp2	-2320.5	5623
Pdpr	-1393.5	3743
Ppard	-3952.5	3976
Rxra	-5660.5	4852

---

---

Biotin-transport-and-metabolism

metric	value
setSize	11
pMANOVA	0.000932
p.adjustMANOVA	0.00926
s.dist	0.652
s.ab	-0.0437
s.d36	0.65
p.ab	0.802
p.d36	0.000189

Gene	ab	d36
Acacb	-5412.5	5448
Hlcs	-4418.5	5724
Pcca	-2030.5	4215
Slc5a6	-2743.5	2729
Mccc1	-1202.5	5073

Click HERE to show all gene set members

	ab	d36
Acaca	5335.5	-48
Acacb	-5412.5	5448
Btd	-540.5	-217
Hlcs	-4418.5	5724
Mccc1	-1202.5	5073
Mccc2	123.5	4709
Pcca	-2030.5	4215
Pccb	1469.5	4972
Pcx	2427.5	5152
Pdzd11	2657.5	3735
Slc5a6	-2743.5	2729

---

---

Peptide-chain-elongation

metric	value
setSize	69
pMANOVA	2.23e-18
p.adjustMANOVA	7.36e-16
s.dist	0.625
s.ab	0.004
s.d36	-0.625
p.ab	0.954
p.d36	2.79e-19

Gene	ab	d36
Eef1a1	5423.5	-5451
Rps23	5402.5	-5063
Rps20	5084.5	-5300
Rps4x	5645.5	-4580
Rpl3	4229.5	-5770
Rpl22	4995.5	-4324
Rpl26	4899.5	-4289
Rpl23	5208.5	-4021
Rps3a1	4558.5	-4165
Rpl22l1	3523.5	-5282
Rpl4	5629.5	-3114
Rps6	5412.5	-3069
Rps24	4956.5	-3149
Rpl14	4942.5	-2991
Rps8	4049.5	-3452
Rps25	4129.5	-3204
Rpl38	3088.5	-4166
Rps7	2833.5	-3831
Rpl27-ps3	5035.5	-2001
Rps27l	3129.5	-3066

Click HERE to show all gene set members

	ab	d36
Eef1a1	5423.5	-5451
Eef2	-5737.5	3284
Flt3l	2020.5	-3039
Rpl10a	-1941.5	-4929
Rpl11	-2529.5	-3606
Rpl12	-3318.5	-2902
Rpl13	-5343.5	-4462
Rpl14	4942.5	-2991
Rpl15	-5749.5	-3305
Rpl18	-1996.5	-4127
Rpl18a	-1154.5	-3833
Rpl19	-1709.5	-4384
Rpl22	4995.5	-4324
Rpl22l1	3523.5	-5282
Rpl23	5208.5	-4021
Rpl23a	4038.5	-1192
Rpl24	2546.5	-3508
Rpl26	4899.5	-4289
Rpl27-ps3	5035.5	-2001
Rpl27a	-3414.5	-4219
Rpl28	-5186.5	-3868
Rpl29	-3224.5	-3135
Rpl3	4229.5	-5770
Rpl30	-3228.5	-4370
Rpl32	-3143.5	-4101
Rpl34	-3795.5	-3996
Rpl35	-3665.5	-3928
Rpl36al	-1509.5	-5050
Rpl37	-2597.5	-2588
Rpl37a	50.5	-4031
Rpl38	3088.5	-4166
Rpl39	1032.5	-4810
Rpl3l	-4110.5	2642
Rpl4	5629.5	-3114
Rpl41	-4354.5	-4635
Rpl5	-4969.5	-3931
Rpl6	1461.5	-3217
Rpl8	-883.5	-4630
Rplp0	-5643.5	-2660
Rplp1	-2371.5	-4419
Rplp2	-4360.5	-4986
Rps11	392.5	-3904
Rps13	-495.5	-3412
Rps14	-186.5	-4375
Rps15a	-3535.5	-2229
Rps16	-3846.5	-5414
Rps17	-1442.5	-4621
Rps18	607.5	-4200
Rps19	-3084.5	-4163
Rps20	5084.5	-5300
Rps21	-2041.5	-3684
Rps23	5402.5	-5063
Rps24	4956.5	-3149
Rps25	4129.5	-3204
Rps26	2173.5	-4049
Rps27	1294.5	-4744
Rps27a	-4190.5	-4207
Rps27l	3129.5	-3066
Rps29	-684.5	-4455
Rps3	-321.5	-4333
Rps3a1	4558.5	-4165
Rps4x	5645.5	-4580
Rps5	-3589.5	-3763
Rps6	5412.5	-3069
Rps7	2833.5	-3831
Rps8	4049.5	-3452
Rps9	-1967.5	-4122
Rpsa	-1204.5	-4470
Uba52	-2952.5	-3903

---

---

Branched-chain-amino-acid-catabolism

metric	value
setSize	20
pMANOVA	1.11e-05
p.adjustMANOVA	0.000279
s.dist	0.614
s.ab	0.000211
s.d36	0.614
p.ab	0.999
p.d36	2e-06

Gene	ab	d36
Slc25a44	4916.5	5022
Ppm1k	1699.5	5569
Hibadh	1994.5	4602
Aldh6a1	2168.5	4053
Acad8	2518.5	3269
Dbt	1437.5	4527
Ivd	1340.5	4608
Acadsb	209.5	4734
Mccc2	123.5	4709
Echs1	164.5	3118

Click HERE to show all gene set members

	ab	d36
Acad8	2518.5	3269
Acadsb	209.5	4734
Acat1	-686.5	5401
Aldh6a1	2168.5	4053
Auh	-3103.5	-110
Bcat2	-584.5	3147
Bckdha	-3922.5	1893
Bckdhb	-3245.5	3419
Bckdk	-2514.5	3033
Dbt	1437.5	4527
Dld	-74.5	4418
Echs1	164.5	3118
Hibadh	1994.5	4602
Hibch	-1215.5	1775
Hsd17b10	-2698.5	-1173
Ivd	1340.5	4608
Mccc1	-1202.5	5073
Mccc2	123.5	4709
Ppm1k	1699.5	5569
Slc25a44	4916.5	5022

---

---

Citric-acid-cycle-(TCA-cycle)

metric	value
setSize	22
pMANOVA	1.42e-05
p.adjustMANOVA	0.00035
s.dist	0.608
s.ab	-0.35
s.d36	0.498
p.ab	0.00452
p.d36	5.33e-05

Gene	ab	d36
Me3	-4723.5	5377
Nnt	-4133.5	5267
Sdha	-3660.5	5084
Cs	-3641.5	5068
Ogdh	-4534.5	3453
Sdhc	-3310.5	4190
Aco2	-1999.5	5196
Idh3g	-3160.5	3102
Idh3b	-3365.5	2855
Fh1	-2493.5	3821
Idh3a	-1539.5	5451
Suclg2	-1506.5	4383
Mdh2	-2195.5	2604
Dlst	-1191.5	4406
Fahd1	-3322.5	751
Sdhd	-715.5	2641
Suclg1	-2218.5	231
Dld	-74.5	4418
Sucla2	-6.5	4032

Click HERE to show all gene set members

	ab	d36
Aco2	-1999.5	5196
Cs	-3641.5	5068
Dld	-74.5	4418
Dlst	-1191.5	4406
Fahd1	-3322.5	751
Fh1	-2493.5	3821
Idh2	-2044.5	-2081
Idh3a	-1539.5	5451
Idh3b	-3365.5	2855
Idh3g	-3160.5	3102
Mdh2	-2195.5	2604
Me2	3078.5	-5586
Me3	-4723.5	5377
Nnt	-4133.5	5267
Ogdh	-4534.5	3453
Sdha	-3660.5	5084
Sdhb	-1815.5	-1632
Sdhc	-3310.5	4190
Sdhd	-715.5	2641
Sucla2	-6.5	4032
Suclg1	-2218.5	231
Suclg2	-1506.5	4383

---

---

Carnitine-metabolism

metric	value
setSize	12
pMANOVA	0.00124
p.adjustMANOVA	0.011
s.dist	0.603
s.ab	0.0429
s.d36	0.601
p.ab	0.797
p.d36	0.000312

Gene	ab	d36
Cpt1a	5087.5	3863
Prkaa2	3048.5	4407
Slc22a5	2824.5	1183

Click HERE to show all gene set members

	ab	d36
Cpt1a	5087.5	3863
Cpt1b	-1527.5	4597
Cpt2	-2215.5	5836
Mid1ip1	-5502.5	5735
Ppard	-3952.5	3976
Prkaa2	3048.5	4407
Prkab2	-1248.5	3948
Prkag2	5723.5	-299
Rxra	-5660.5	4852
Slc22a5	2824.5	1183
Slc25a20	-233.5	5561
Thrsp	5092.5	-1897

---

---

Viral-mRNA-Translation

metric	value
setSize	69
pMANOVA	3.98e-17
p.adjustMANOVA	6.45e-15
s.dist	0.602
s.ab	-0.0011
s.d36	-0.602
p.ab	0.987
p.d36	5.35e-18

Gene	ab	d36
Rpl13	-5343.5	-4462
Rplp2	-4360.5	-4986
Rps16	-3846.5	-5414
Rpl41	-4354.5	-4635
Rpl28	-5186.5	-3868
Rpl5	-4969.5	-3931
Rpl15	-5749.5	-3305
Rps27a	-4190.5	-4207
Rpl34	-3795.5	-3996
Rplp0	-5643.5	-2660
Rpl27a	-3414.5	-4219
Rpl35	-3665.5	-3928
Rpl30	-3228.5	-4370
Rps5	-3589.5	-3763
Rpl32	-3143.5	-4101
Rps19	-3084.5	-4163
Uba52	-2952.5	-3903
Rplp1	-2371.5	-4419
Rpl29	-3224.5	-3135
Rpl12	-3318.5	-2902

Click HERE to show all gene set members

	ab	d36
Dnajc3	-1675.5	3671
Flt3l	2020.5	-3039
Grsf1	-714.5	3514
Rpl10a	-1941.5	-4929
Rpl11	-2529.5	-3606
Rpl12	-3318.5	-2902
Rpl13	-5343.5	-4462
Rpl14	4942.5	-2991
Rpl15	-5749.5	-3305
Rpl18	-1996.5	-4127
Rpl18a	-1154.5	-3833
Rpl19	-1709.5	-4384
Rpl22	4995.5	-4324
Rpl22l1	3523.5	-5282
Rpl23	5208.5	-4021
Rpl23a	4038.5	-1192
Rpl24	2546.5	-3508
Rpl26	4899.5	-4289
Rpl27-ps3	5035.5	-2001
Rpl27a	-3414.5	-4219
Rpl28	-5186.5	-3868
Rpl29	-3224.5	-3135
Rpl3	4229.5	-5770
Rpl30	-3228.5	-4370
Rpl32	-3143.5	-4101
Rpl34	-3795.5	-3996
Rpl35	-3665.5	-3928
Rpl36al	-1509.5	-5050
Rpl37	-2597.5	-2588
Rpl37a	50.5	-4031
Rpl38	3088.5	-4166
Rpl39	1032.5	-4810
Rpl3l	-4110.5	2642
Rpl4	5629.5	-3114
Rpl41	-4354.5	-4635
Rpl5	-4969.5	-3931
Rpl6	1461.5	-3217
Rpl8	-883.5	-4630
Rplp0	-5643.5	-2660
Rplp1	-2371.5	-4419
Rplp2	-4360.5	-4986
Rps11	392.5	-3904
Rps13	-495.5	-3412
Rps14	-186.5	-4375
Rps15a	-3535.5	-2229
Rps16	-3846.5	-5414
Rps17	-1442.5	-4621
Rps18	607.5	-4200
Rps19	-3084.5	-4163
Rps20	5084.5	-5300
Rps21	-2041.5	-3684
Rps23	5402.5	-5063
Rps24	4956.5	-3149
Rps25	4129.5	-3204
Rps26	2173.5	-4049
Rps27	1294.5	-4744
Rps27a	-4190.5	-4207
Rps27l	3129.5	-3066
Rps29	-684.5	-4455
Rps3	-321.5	-4333
Rps3a1	4558.5	-4165
Rps4x	5645.5	-4580
Rps5	-3589.5	-3763
Rps6	5412.5	-3069
Rps7	2833.5	-3831
Rps8	4049.5	-3452
Rps9	-1967.5	-4122
Rpsa	-1204.5	-4470
Uba52	-2952.5	-3903

---

---

Eukaryotic-Translation-Elongation

metric	value
setSize	73
pMANOVA	1.21e-17
p.adjustMANOVA	2.99e-15
s.dist	0.595
s.ab	0.00569
s.d36	-0.595
p.ab	0.933
p.d36	1.49e-18

Gene	ab	d36
Eef1a1	5423.5	-5451
Rps23	5402.5	-5063
Rps20	5084.5	-5300
Rps4x	5645.5	-4580
Rpl3	4229.5	-5770
Rpl22	4995.5	-4324
Rpl26	4899.5	-4289
Rpl23	5208.5	-4021
Rps3a1	4558.5	-4165
Rpl22l1	3523.5	-5282
Rpl4	5629.5	-3114
Rps6	5412.5	-3069
Rps24	4956.5	-3149
Rpl14	4942.5	-2991
Rps8	4049.5	-3452
Rps25	4129.5	-3204
Rpl38	3088.5	-4166
Rps7	2833.5	-3831
Eef1b2	4624.5	-2338
Rpl27-ps3	5035.5	-2001

Click HERE to show all gene set members

	ab	d36
Eef1a1	5423.5	-5451
Eef1a2	-5103.5	5587
Eef1b2	4624.5	-2338
Eef1d	-2694.5	-3096
Eef1g	3456.5	-2304
Eef2	-5737.5	3284
Flt3l	2020.5	-3039
Rpl10a	-1941.5	-4929
Rpl11	-2529.5	-3606
Rpl12	-3318.5	-2902
Rpl13	-5343.5	-4462
Rpl14	4942.5	-2991
Rpl15	-5749.5	-3305
Rpl18	-1996.5	-4127
Rpl18a	-1154.5	-3833
Rpl19	-1709.5	-4384
Rpl22	4995.5	-4324
Rpl22l1	3523.5	-5282
Rpl23	5208.5	-4021
Rpl23a	4038.5	-1192
Rpl24	2546.5	-3508
Rpl26	4899.5	-4289
Rpl27-ps3	5035.5	-2001
Rpl27a	-3414.5	-4219
Rpl28	-5186.5	-3868
Rpl29	-3224.5	-3135
Rpl3	4229.5	-5770
Rpl30	-3228.5	-4370
Rpl32	-3143.5	-4101
Rpl34	-3795.5	-3996
Rpl35	-3665.5	-3928
Rpl36al	-1509.5	-5050
Rpl37	-2597.5	-2588
Rpl37a	50.5	-4031
Rpl38	3088.5	-4166
Rpl39	1032.5	-4810
Rpl3l	-4110.5	2642
Rpl4	5629.5	-3114
Rpl41	-4354.5	-4635
Rpl5	-4969.5	-3931
Rpl6	1461.5	-3217
Rpl8	-883.5	-4630
Rplp0	-5643.5	-2660
Rplp1	-2371.5	-4419
Rplp2	-4360.5	-4986
Rps11	392.5	-3904
Rps13	-495.5	-3412
Rps14	-186.5	-4375
Rps15a	-3535.5	-2229
Rps16	-3846.5	-5414
Rps17	-1442.5	-4621
Rps18	607.5	-4200
Rps19	-3084.5	-4163
Rps20	5084.5	-5300
Rps21	-2041.5	-3684
Rps23	5402.5	-5063
Rps24	4956.5	-3149
Rps25	4129.5	-3204
Rps26	2173.5	-4049
Rps27	1294.5	-4744
Rps27a	-4190.5	-4207
Rps27l	3129.5	-3066
Rps29	-684.5	-4455
Rps3	-321.5	-4333
Rps3a1	4558.5	-4165
Rps4x	5645.5	-4580
Rps5	-3589.5	-3763
Rps6	5412.5	-3069
Rps7	2833.5	-3831
Rps8	4049.5	-3452
Rps9	-1967.5	-4122
Rpsa	-1204.5	-4470
Uba52	-2952.5	-3903

---

---

Eukaryotic-Translation-Termination

metric	value
setSize	72
pMANOVA	3.35e-17
p.adjustMANOVA	6.45e-15
s.dist	0.588
s.ab	-0.0215
s.d36	-0.588
p.ab	0.753
p.d36	6.16e-18

Gene	ab	d36
Rpl13	-5343.5	-4462
Rplp2	-4360.5	-4986
Rps16	-3846.5	-5414
Rpl41	-4354.5	-4635
Rpl28	-5186.5	-3868
Rpl5	-4969.5	-3931
Rpl15	-5749.5	-3305
Rps27a	-4190.5	-4207
Rpl34	-3795.5	-3996
Rplp0	-5643.5	-2660
Rpl27a	-3414.5	-4219
Rpl35	-3665.5	-3928
Rpl30	-3228.5	-4370
Rps5	-3589.5	-3763
Trmt112	-3936.5	-3298
Rpl32	-3143.5	-4101
Rps19	-3084.5	-4163
Uba52	-2952.5	-3903
Rplp1	-2371.5	-4419
Rpl29	-3224.5	-3135

Click HERE to show all gene set members

	ab	d36
Apeh	-5235.5	461
Etf1	-2724.5	2042
Flt3l	2020.5	-3039
Gspt1	-3382.5	2577
N6amt1	3799.5	375
Rpl10a	-1941.5	-4929
Rpl11	-2529.5	-3606
Rpl12	-3318.5	-2902
Rpl13	-5343.5	-4462
Rpl14	4942.5	-2991
Rpl15	-5749.5	-3305
Rpl18	-1996.5	-4127
Rpl18a	-1154.5	-3833
Rpl19	-1709.5	-4384
Rpl22	4995.5	-4324
Rpl22l1	3523.5	-5282
Rpl23	5208.5	-4021
Rpl23a	4038.5	-1192
Rpl24	2546.5	-3508
Rpl26	4899.5	-4289
Rpl27-ps3	5035.5	-2001
Rpl27a	-3414.5	-4219
Rpl28	-5186.5	-3868
Rpl29	-3224.5	-3135
Rpl3	4229.5	-5770
Rpl30	-3228.5	-4370
Rpl32	-3143.5	-4101
Rpl34	-3795.5	-3996
Rpl35	-3665.5	-3928
Rpl36al	-1509.5	-5050
Rpl37	-2597.5	-2588
Rpl37a	50.5	-4031
Rpl38	3088.5	-4166
Rpl39	1032.5	-4810
Rpl3l	-4110.5	2642
Rpl4	5629.5	-3114
Rpl41	-4354.5	-4635
Rpl5	-4969.5	-3931
Rpl6	1461.5	-3217
Rpl8	-883.5	-4630
Rplp0	-5643.5	-2660
Rplp1	-2371.5	-4419
Rplp2	-4360.5	-4986
Rps11	392.5	-3904
Rps13	-495.5	-3412
Rps14	-186.5	-4375
Rps15a	-3535.5	-2229
Rps16	-3846.5	-5414
Rps17	-1442.5	-4621
Rps18	607.5	-4200
Rps19	-3084.5	-4163
Rps20	5084.5	-5300
Rps21	-2041.5	-3684
Rps23	5402.5	-5063
Rps24	4956.5	-3149
Rps25	4129.5	-3204
Rps26	2173.5	-4049
Rps27	1294.5	-4744
Rps27a	-4190.5	-4207
Rps27l	3129.5	-3066
Rps29	-684.5	-4455
Rps3	-321.5	-4333
Rps3a1	4558.5	-4165
Rps4x	5645.5	-4580
Rps5	-3589.5	-3763
Rps6	5412.5	-3069
Rps7	2833.5	-3831
Rps8	4049.5	-3452
Rps9	-1967.5	-4122
Rpsa	-1204.5	-4470
Trmt112	-3936.5	-3298
Uba52	-2952.5	-3903

---

---

Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency

metric	value
setSize	80
pMANOVA	1.58e-18
p.adjustMANOVA	7.36e-16
s.dist	0.587
s.ab	0.0457
s.d36	-0.585
p.ab	0.481
p.d36	1.4e-19

Gene	ab	d36
Rps23	5402.5	-5063
Rps20	5084.5	-5300
Rps4x	5645.5	-4580
Rpl3	4229.5	-5770
Atf3	4189.5	-5786
Ddit3	4493.5	-5098
Rpl22	4995.5	-4324
Rpl26	4899.5	-4289
Rpl23	5208.5	-4021
Rps3a1	4558.5	-4165
Rpl22l1	3523.5	-5282
Rpl4	5629.5	-3114
Rps6	5412.5	-3069
Rps24	4956.5	-3149
Rpl14	4942.5	-2991
Rps8	4049.5	-3452
Asns	5277.5	-2511
Rps25	4129.5	-3204
Rpl38	3088.5	-4166
Rps7	2833.5	-3831

Click HERE to show all gene set members

	ab	d36
Asns	5277.5	-2511
Atf2	4155.5	2027
Atf3	4189.5	-5786
Atf4	1220.5	-4828
Cebpb	-4061.5	1643
Cebpg	2577.5	-2114
Ddit3	4493.5	-5098
Eif2ak4	2060.5	-3104
Eif2s1	290.5	1361
Eif2s2	-3841.5	-2841
Eif2s3x	-778.5	3655
Flt3l	2020.5	-3039
Impact	1551.5	-5220
Rpl10a	-1941.5	-4929
Rpl11	-2529.5	-3606
Rpl12	-3318.5	-2902
Rpl13	-5343.5	-4462
Rpl14	4942.5	-2991
Rpl15	-5749.5	-3305
Rpl18	-1996.5	-4127
Rpl18a	-1154.5	-3833
Rpl19	-1709.5	-4384
Rpl22	4995.5	-4324
Rpl22l1	3523.5	-5282
Rpl23	5208.5	-4021
Rpl23a	4038.5	-1192
Rpl24	2546.5	-3508
Rpl26	4899.5	-4289
Rpl27-ps3	5035.5	-2001
Rpl27a	-3414.5	-4219
Rpl28	-5186.5	-3868
Rpl29	-3224.5	-3135
Rpl3	4229.5	-5770
Rpl30	-3228.5	-4370
Rpl32	-3143.5	-4101
Rpl34	-3795.5	-3996
Rpl35	-3665.5	-3928
Rpl36al	-1509.5	-5050
Rpl37	-2597.5	-2588
Rpl37a	50.5	-4031
Rpl38	3088.5	-4166
Rpl39	1032.5	-4810
Rpl3l	-4110.5	2642
Rpl4	5629.5	-3114
Rpl41	-4354.5	-4635
Rpl5	-4969.5	-3931
Rpl6	1461.5	-3217
Rpl8	-883.5	-4630
Rplp0	-5643.5	-2660
Rplp1	-2371.5	-4419
Rplp2	-4360.5	-4986
Rps11	392.5	-3904
Rps13	-495.5	-3412
Rps14	-186.5	-4375
Rps15a	-3535.5	-2229
Rps16	-3846.5	-5414
Rps17	-1442.5	-4621
Rps18	607.5	-4200
Rps19	-3084.5	-4163
Rps20	5084.5	-5300
Rps21	-2041.5	-3684
Rps23	5402.5	-5063
Rps24	4956.5	-3149
Rps25	4129.5	-3204
Rps26	2173.5	-4049
Rps27	1294.5	-4744
Rps27a	-4190.5	-4207
Rps27l	3129.5	-3066
Rps29	-684.5	-4455
Rps3	-321.5	-4333
Rps3a1	4558.5	-4165
Rps4x	5645.5	-4580
Rps5	-3589.5	-3763
Rps6	5412.5	-3069
Rps7	2833.5	-3831
Rps8	4049.5	-3452
Rps9	-1967.5	-4122
Rpsa	-1204.5	-4470
Trib3	987.5	-1981
Uba52	-2952.5	-3903

---

---

Selenocysteine-synthesis

metric	value
setSize	73
pMANOVA	4.18e-17
p.adjustMANOVA	6.45e-15
s.dist	0.584
s.ab	-0.00957
s.d36	-0.584
p.ab	0.888
p.d36	6.35e-18

Gene	ab	d36
Rpl13	-5343.5	-4462
Rplp2	-4360.5	-4986
Rps16	-3846.5	-5414
Rpl41	-4354.5	-4635
Rpl28	-5186.5	-3868
Rpl5	-4969.5	-3931
Rpl15	-5749.5	-3305
Rps27a	-4190.5	-4207
Rpl34	-3795.5	-3996
Rplp0	-5643.5	-2660
Rpl27a	-3414.5	-4219
Rpl35	-3665.5	-3928
Rpl30	-3228.5	-4370
Rps5	-3589.5	-3763
Rpl32	-3143.5	-4101
Rps19	-3084.5	-4163
Uba52	-2952.5	-3903
Rplp1	-2371.5	-4419
Rpl29	-3224.5	-3135
Rpl12	-3318.5	-2902

Click HERE to show all gene set members

	ab	d36
Eefsec	-894.5	-2973
Flt3l	2020.5	-3039
Pstk	-4403.5	5239
Rpl10a	-1941.5	-4929
Rpl11	-2529.5	-3606
Rpl12	-3318.5	-2902
Rpl13	-5343.5	-4462
Rpl14	4942.5	-2991
Rpl15	-5749.5	-3305
Rpl18	-1996.5	-4127
Rpl18a	-1154.5	-3833
Rpl19	-1709.5	-4384
Rpl22	4995.5	-4324
Rpl22l1	3523.5	-5282
Rpl23	5208.5	-4021
Rpl23a	4038.5	-1192
Rpl24	2546.5	-3508
Rpl26	4899.5	-4289
Rpl27-ps3	5035.5	-2001
Rpl27a	-3414.5	-4219
Rpl28	-5186.5	-3868
Rpl29	-3224.5	-3135
Rpl3	4229.5	-5770
Rpl30	-3228.5	-4370
Rpl32	-3143.5	-4101
Rpl34	-3795.5	-3996
Rpl35	-3665.5	-3928
Rpl36al	-1509.5	-5050
Rpl37	-2597.5	-2588
Rpl37a	50.5	-4031
Rpl38	3088.5	-4166
Rpl39	1032.5	-4810
Rpl3l	-4110.5	2642
Rpl4	5629.5	-3114
Rpl41	-4354.5	-4635
Rpl5	-4969.5	-3931
Rpl6	1461.5	-3217
Rpl8	-883.5	-4630
Rplp0	-5643.5	-2660
Rplp1	-2371.5	-4419
Rplp2	-4360.5	-4986
Rps11	392.5	-3904
Rps13	-495.5	-3412
Rps14	-186.5	-4375
Rps15a	-3535.5	-2229
Rps16	-3846.5	-5414
Rps17	-1442.5	-4621
Rps18	607.5	-4200
Rps19	-3084.5	-4163
Rps20	5084.5	-5300
Rps21	-2041.5	-3684
Rps23	5402.5	-5063
Rps24	4956.5	-3149
Rps25	4129.5	-3204
Rps26	2173.5	-4049
Rps27	1294.5	-4744
Rps27a	-4190.5	-4207
Rps27l	3129.5	-3066
Rps29	-684.5	-4455
Rps3	-321.5	-4333
Rps3a1	4558.5	-4165
Rps4x	5645.5	-4580
Rps5	-3589.5	-3763
Rps6	5412.5	-3069
Rps7	2833.5	-3831
Rps8	4049.5	-3452
Rps9	-1967.5	-4122
Rpsa	-1204.5	-4470
Sars	-5060.5	575
Secisbp2	-4620.5	857
Sephs2	4892.5	-4752
Sepsecs	3483.5	1508
Uba52	-2952.5	-3903

---

---

Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)

metric	value
setSize	73
pMANOVA	2.35e-16
p.adjustMANOVA	3.22e-14
s.dist	0.57
s.ab	-0.0186
s.d36	-0.569
p.ab	0.783
p.d36	4.12e-17

Gene	ab	d36
Rpl13	-5343.5	-4462
Rplp2	-4360.5	-4986
Rps16	-3846.5	-5414
Rpl41	-4354.5	-4635
Rpl28	-5186.5	-3868
Rpl5	-4969.5	-3931
Rpl15	-5749.5	-3305
Rps27a	-4190.5	-4207
Rpl34	-3795.5	-3996
Rplp0	-5643.5	-2660
Rpl27a	-3414.5	-4219
Rpl35	-3665.5	-3928
Rpl30	-3228.5	-4370
Rps5	-3589.5	-3763
Rpl32	-3143.5	-4101
Rps19	-3084.5	-4163
Uba52	-2952.5	-3903
Rplp1	-2371.5	-4419
Rpl29	-3224.5	-3135
Rpl12	-3318.5	-2902

Click HERE to show all gene set members

	ab	d36
Eif4g1	-2207.5	3277
Etf1	-2724.5	2042
Flt3l	2020.5	-3039
Gspt1	-3382.5	2577
Ncbp1	-1856.5	-2759
Ncbp2	335.5	-250
Rpl10a	-1941.5	-4929
Rpl11	-2529.5	-3606
Rpl12	-3318.5	-2902
Rpl13	-5343.5	-4462
Rpl14	4942.5	-2991
Rpl15	-5749.5	-3305
Rpl18	-1996.5	-4127
Rpl18a	-1154.5	-3833
Rpl19	-1709.5	-4384
Rpl22	4995.5	-4324
Rpl22l1	3523.5	-5282
Rpl23	5208.5	-4021
Rpl23a	4038.5	-1192
Rpl24	2546.5	-3508
Rpl26	4899.5	-4289
Rpl27-ps3	5035.5	-2001
Rpl27a	-3414.5	-4219
Rpl28	-5186.5	-3868
Rpl29	-3224.5	-3135
Rpl3	4229.5	-5770
Rpl30	-3228.5	-4370
Rpl32	-3143.5	-4101
Rpl34	-3795.5	-3996
Rpl35	-3665.5	-3928
Rpl36al	-1509.5	-5050
Rpl37	-2597.5	-2588
Rpl37a	50.5	-4031
Rpl38	3088.5	-4166
Rpl39	1032.5	-4810
Rpl3l	-4110.5	2642
Rpl4	5629.5	-3114
Rpl41	-4354.5	-4635
Rpl5	-4969.5	-3931
Rpl6	1461.5	-3217
Rpl8	-883.5	-4630
Rplp0	-5643.5	-2660
Rplp1	-2371.5	-4419
Rplp2	-4360.5	-4986
Rps11	392.5	-3904
Rps13	-495.5	-3412
Rps14	-186.5	-4375
Rps15a	-3535.5	-2229
Rps16	-3846.5	-5414
Rps17	-1442.5	-4621
Rps18	607.5	-4200
Rps19	-3084.5	-4163
Rps20	5084.5	-5300
Rps21	-2041.5	-3684
Rps23	5402.5	-5063
Rps24	4956.5	-3149
Rps25	4129.5	-3204
Rps26	2173.5	-4049
Rps27	1294.5	-4744
Rps27a	-4190.5	-4207
Rps27l	3129.5	-3066
Rps29	-684.5	-4455
Rps3	-321.5	-4333
Rps3a1	4558.5	-4165
Rps4x	5645.5	-4580
Rps5	-3589.5	-3763
Rps6	5412.5	-3069
Rps7	2833.5	-3831
Rps8	4049.5	-3452
Rps9	-1967.5	-4122
Rpsa	-1204.5	-4470
Uba52	-2952.5	-3903
Upf1	-675.5	1867

---

---

Physiological-factors

metric	value
setSize	11
pMANOVA	0.00273
p.adjustMANOVA	0.0201
s.dist	0.569
s.ab	0.327
s.d36	0.466
p.ab	0.0603
p.d36	0.00749

Gene	ab	d36
Nppa	5691.5	5709
Corin	4788.5	3911
Tbx5	5394.5	1823
Wwtr1	4507.5	1208
Npr2	2678.5	1726
Hipk2	1007.5	3765
Hipk1	33.5	1662

Click HERE to show all gene set members

	ab	d36
Corin	4788.5	3911
Gata4	-5268.5	4151
Hipk1	33.5	1662
Hipk2	1007.5	3765
Kat2b	-304.5	4890
Nkx2-5	-3190.5	4590
Nppa	5691.5	5709
Npr1	4525.5	-3976
Npr2	2678.5	1726
Tbx5	5394.5	1823
Wwtr1	4507.5	1208

---

---

Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle

metric	value
setSize	50
pMANOVA	2.52e-10
p.adjustMANOVA	1.15e-08
s.dist	0.567
s.ab	-0.305
s.d36	0.478
p.ab	0.00019
p.d36	5.06e-09

Gene	ab	d36
Rxra	-5660.5	4852
Pdk2	-4667.5	5542
Me3	-4723.5	5377
Me1	-4151.5	5434
Pdp1	-3944.5	5660
Nnt	-4133.5	5267
D2hgdh	-3542.5	5573
Sdha	-3660.5	5084
Cs	-3641.5	5068
L2hgdh	-3319.5	5266
Vdac1	-3120.5	5253
Ppard	-3952.5	3976
Ogdh	-4534.5	3453
Pdk4	-2607.5	5541
Sdhc	-3310.5	4190
Pdp2	-2320.5	5623
Aco2	-1999.5	5196
Idh3g	-3160.5	3102
Idh3b	-3365.5	2855
Fh1	-2493.5	3821

Click HERE to show all gene set members

	ab	d36
Aco2	-1999.5	5196
Adhfe1	-258.5	5579
Bsg	-3352.5	403
Cs	-3641.5	5068
D2hgdh	-3542.5	5573
Dlat	-1788.5	3921
Dld	-74.5	4418
Dlst	-1191.5	4406
Fahd1	-3322.5	751
Fh1	-2493.5	3821
Glo1	538.5	2947
Gstz1	4779.5	2839
Hagh	-3951.5	-2989
Idh2	-2044.5	-2081
Idh3a	-1539.5	5451
Idh3b	-3365.5	2855
Idh3g	-3160.5	3102
L2hgdh	-3319.5	5266
Ldha	-4261.5	-1535
Ldhb	-1477.5	532
Mdh2	-2195.5	2604
Me1	-4151.5	5434
Me2	3078.5	-5586
Me3	-4723.5	5377
Mpc1	-2394.5	440
Mpc2	-2713.5	-1034
Nnt	-4133.5	5267
Ogdh	-4534.5	3453
Pdha1	-1301.5	4866
Pdhb	-242.5	1105
Pdhx	2159.5	1148
Pdk1	-838.5	4653
Pdk2	-4667.5	5542
Pdk3	5741.5	-572
Pdk4	-2607.5	5541
Pdp1	-3944.5	5660
Pdp2	-2320.5	5623
Pdpr	-1393.5	3743
Ppard	-3952.5	3976
Rxra	-5660.5	4852
Sdha	-3660.5	5084
Sdhb	-1815.5	-1632
Sdhc	-3310.5	4190
Sdhd	-715.5	2641
Slc16a1	-3831.5	892
Slc16a3	3452.5	-5626
Sucla2	-6.5	4032
Suclg1	-2218.5	231
Suclg2	-1506.5	4383
Vdac1	-3120.5	5253

---

---

PI-3K-cascade:FGFR3

metric	value
setSize	11
pMANOVA	0.00802
p.adjustMANOVA	0.0471
s.dist	0.562
s.ab	-0.265
s.d36	0.496
p.ab	0.128
p.d36	0.00442

Gene	ab	d36
Fgf1	-3926.5	5665
Fgf16	-4034.5	5094
Fgf9	-5772.5	3111
Gab1	-3225.5	4420
Pik3r1	-2910.5	4811
Frs2	-4622.5	229
Pik3ca	-75.5	473

Click HERE to show all gene set members

	ab	d36
Fgf1	-3926.5	5665
Fgf16	-4034.5	5094
Fgf2	165.5	5279
Fgf9	-5772.5	3111
Fgfr3	-572.5	-5392
Frs2	-4622.5	229
Gab1	-3225.5	4420
Grb2	4354.5	5789
Pik3ca	-75.5	473
Pik3r1	-2910.5	4811
Ptpn11	1827.5	1935

---

---

Constitutive-Signaling-by-NOTCH1-HD-Domain-Mutants

metric	value
setSize	14
pMANOVA	0.000728
p.adjustMANOVA	0.00788
s.dist	0.557
s.ab	-0.379
s.d36	-0.408
p.ab	0.0141
p.d36	0.00827

Gene	ab	d36
Jag2	-5622.5	-4343
Jag1	-3442.5	-5169
Rps27a	-4190.5	-4207
Neurl1a	-4386.5	-3781
Dll4	-2189.5	-6016
Mib2	-4715.5	-2662
Uba52	-2952.5	-3903
Ubb	-2267.5	-1407
Adam10	-596.5	-1314

Click HERE to show all gene set members

	ab	d36
Adam10	-596.5	-1314
Adam17	-5932.5	940
Dll1	-5422.5	1293
Dll4	-2189.5	-6016
Jag1	-3442.5	-5169
Jag2	-5622.5	-4343
Mib1	5391.5	4576
Mib2	-4715.5	-2662
Neurl1a	-4386.5	-3781
Neurl1b	68.5	-5045
Notch1	2890.5	-3995
Rps27a	-4190.5	-4207
Uba52	-2952.5	-3903
Ubb	-2267.5	-1407

---

---

Signaling-by-NOTCH1-HD-Domain-Mutants-in-Cancer

metric	value
setSize	14
pMANOVA	0.000728
p.adjustMANOVA	0.00788
s.dist	0.557
s.ab	-0.379
s.d36	-0.408
p.ab	0.0141
p.d36	0.00827

Gene	ab	d36
Jag2	-5622.5	-4343
Jag1	-3442.5	-5169
Rps27a	-4190.5	-4207
Neurl1a	-4386.5	-3781
Dll4	-2189.5	-6016
Mib2	-4715.5	-2662
Uba52	-2952.5	-3903
Ubb	-2267.5	-1407
Adam10	-596.5	-1314

Click HERE to show all gene set members

	ab	d36
Adam10	-596.5	-1314
Adam17	-5932.5	940
Dll1	-5422.5	1293
Dll4	-2189.5	-6016
Jag1	-3442.5	-5169
Jag2	-5622.5	-4343
Mib1	5391.5	4576
Mib2	-4715.5	-2662
Neurl1a	-4386.5	-3781
Neurl1b	68.5	-5045
Notch1	2890.5	-3995
Rps27a	-4190.5	-4207
Uba52	-2952.5	-3903
Ubb	-2267.5	-1407

---

---

PI-3K-cascade:FGFR1

metric	value
setSize	10
pMANOVA	0.0141
p.adjustMANOVA	0.0721
s.dist	0.547
s.ab	-0.168
s.d36	0.52
p.ab	0.356
p.d36	0.00441

Gene	ab	d36
Fgf1	-3926.5	5665
Fgf9	-5772.5	3111
Gab1	-3225.5	4420
Pik3r1	-2910.5	4811
Frs2	-4622.5	229
Pik3ca	-75.5	473

Click HERE to show all gene set members

	ab	d36
Fgf1	-3926.5	5665
Fgf2	165.5	5279
Fgf9	-5772.5	3111
Fgfr1	2843.5	-1711
Frs2	-4622.5	229
Gab1	-3225.5	4420
Grb2	4354.5	5789
Pik3ca	-75.5	473
Pik3r1	-2910.5	4811
Ptpn11	1827.5	1935

---

---

Prolactin-receptor-signaling

metric	value
setSize	10
pMANOVA	0.0102
p.adjustMANOVA	0.0565
s.dist	0.532
s.ab	0.206
s.d36	0.49
p.ab	0.258
p.d36	0.00729

Gene	ab	d36
Cul1	3128.5	5019
Skp1a	3485.5	3561
Jak2	3917.5	2392
Stat5b	2646.5	2564
Ptpn11	1827.5	1935
Ghr	877.5	3666

Click HERE to show all gene set members

	ab	d36
Btrc	-2260.5	5798
Cul1	3128.5	5019
Ghr	877.5	3666
Jak2	3917.5	2392
Ptpn11	1827.5	1935
Rbx1	1071.5	-3541
Sh2b1	-923.5	1127
Skp1a	3485.5	3561
Stat5a	-2873.5	5707
Stat5b	2646.5	2564

---

---

eNOS-activation

metric	value
setSize	11
pMANOVA	0.0099
p.adjustMANOVA	0.0553
s.dist	0.527
s.ab	0.00508
s.d36	-0.527
p.ab	0.977
p.d36	0.00248

Gene	ab	d36
Cav1	4754.5	-5886
Nos3	3513.5	-5802
Zdhhc21	1540.5	-5484
Calm1	1392.5	-5536
Spr	602.5	-3175

Click HERE to show all gene set members

	ab	d36
Akt1	-4927.5	-1552
Calm1	1392.5	-5536
Cav1	4754.5	-5886
Cygb	-2389.5	-4825
Ddah1	-4911.5	1178
Ddah2	-24.5	-2037
Hsp90aa1	-668.5	-4565
Lypla1	-35.5	2373
Nos3	3513.5	-5802
Spr	602.5	-3175
Zdhhc21	1540.5	-5484

---

---

CS/DS-degradation

metric	value
setSize	10
pMANOVA	0.025
p.adjustMANOVA	0.108
s.dist	0.52
s.ab	0.338
s.d36	-0.395
p.ab	0.0643
p.d36	0.0306

Gene	ab	d36
Bgn	3222.5	-5250
Arsb	4253.5	-3367
Hyal1	5068.5	-2362
Cspg4	2597.5	-4531
Hexb	4240.5	-2476
Dcn	1015.5	-4121

Click HERE to show all gene set members

	ab	d36
Arsb	4253.5	-3367
Bgn	3222.5	-5250
Cspg4	2597.5	-4531
Dcn	1015.5	-4121
Hexa	-1661.5	-5388
Hexb	4240.5	-2476
Hyal1	5068.5	-2362
Ids	884.5	1870
Idua	-2544.5	996
Vcan	1621.5	352

---

---

Formation-of-a-pool-of-free-40S-subunits

metric	value
setSize	81
pMANOVA	4.27e-15
p.adjustMANOVA	4.79e-13
s.dist	0.516
s.ab	-0.0445
s.d36	-0.514
p.ab	0.489
p.d36	1.29e-15

Gene	ab	d36
Eif3d	-5990.5	-4761
Rpl13	-5343.5	-4462
Rplp2	-4360.5	-4986
Rps16	-3846.5	-5414
Rpl41	-4354.5	-4635
Rpl28	-5186.5	-3868
Rpl5	-4969.5	-3931
Rpl15	-5749.5	-3305
Eif3k	-4571.5	-3934
Rps27a	-4190.5	-4207
Rpl34	-3795.5	-3996
Rplp0	-5643.5	-2660
Rpl27a	-3414.5	-4219
Rpl35	-3665.5	-3928
Rpl30	-3228.5	-4370
Rps5	-3589.5	-3763
Rpl32	-3143.5	-4101
Rps19	-3084.5	-4163
Uba52	-2952.5	-3903
Rplp1	-2371.5	-4419

Click HERE to show all gene set members

	ab	d36
Eif1ax	1482.5	4994
Eif3a	-2077.5	3749
Eif3b	-4137.5	3505
Eif3c	-4989.5	2476
Eif3d	-5990.5	-4761
Eif3e	4518.5	-631
Eif3f	894.5	-1883
Eif3g	-3783.5	-1654
Eif3h	-453.5	1501
Eif3i	256.5	-2586
Eif3j2	-5246.5	3758
Eif3k	-4571.5	-3934
Eif3l	-3034.5	1013
Eif3m	2305.5	208
Flt3l	2020.5	-3039
Rpl10a	-1941.5	-4929
Rpl11	-2529.5	-3606
Rpl12	-3318.5	-2902
Rpl13	-5343.5	-4462
Rpl14	4942.5	-2991
Rpl15	-5749.5	-3305
Rpl18	-1996.5	-4127
Rpl18a	-1154.5	-3833
Rpl19	-1709.5	-4384
Rpl22	4995.5	-4324
Rpl22l1	3523.5	-5282
Rpl23	5208.5	-4021
Rpl23a	4038.5	-1192
Rpl24	2546.5	-3508
Rpl26	4899.5	-4289
Rpl27-ps3	5035.5	-2001
Rpl27a	-3414.5	-4219
Rpl28	-5186.5	-3868
Rpl29	-3224.5	-3135
Rpl3	4229.5	-5770
Rpl30	-3228.5	-4370
Rpl32	-3143.5	-4101
Rpl34	-3795.5	-3996
Rpl35	-3665.5	-3928
Rpl36al	-1509.5	-5050
Rpl37	-2597.5	-2588
Rpl37a	50.5	-4031
Rpl38	3088.5	-4166
Rpl39	1032.5	-4810
Rpl3l	-4110.5	2642
Rpl4	5629.5	-3114
Rpl41	-4354.5	-4635
Rpl5	-4969.5	-3931
Rpl6	1461.5	-3217
Rpl8	-883.5	-4630
Rplp0	-5643.5	-2660
Rplp1	-2371.5	-4419
Rplp2	-4360.5	-4986
Rps11	392.5	-3904
Rps13	-495.5	-3412
Rps14	-186.5	-4375
Rps15a	-3535.5	-2229
Rps16	-3846.5	-5414
Rps17	-1442.5	-4621
Rps18	607.5	-4200
Rps19	-3084.5	-4163
Rps20	5084.5	-5300
Rps21	-2041.5	-3684
Rps23	5402.5	-5063
Rps24	4956.5	-3149
Rps25	4129.5	-3204
Rps26	2173.5	-4049
Rps27	1294.5	-4744
Rps27a	-4190.5	-4207
Rps27l	3129.5	-3066
Rps29	-684.5	-4455
Rps3	-321.5	-4333
Rps3a1	4558.5	-4165
Rps4x	5645.5	-4580
Rps5	-3589.5	-3763
Rps6	5412.5	-3069
Rps7	2833.5	-3831
Rps8	4049.5	-3452
Rps9	-1967.5	-4122
Rpsa	-1204.5	-4470
Uba52	-2952.5	-3903

---

---

Voltage-gated-Potassium-channels

metric	value
setSize	13
pMANOVA	0.00756
p.adjustMANOVA	0.0453
s.dist	0.516
s.ab	-0.185
s.d36	0.481
p.ab	0.248
p.d36	0.00265

Gene	ab	d36
Kcnb1	-5019.5	5736
Kcng2	-5044.5	4262
Kcnv2	-3918.5	4393
Kcnd2	-1801.5	5545
Kcna7	-1218.5	3160
Kcnd3	-381.5	4361

Click HERE to show all gene set members

	ab	d36
Kcna2	1184.5	377
Kcna5	-4254.5	-1467
Kcna6	-1161.5	-1157
Kcna7	-1218.5	3160
Kcnb1	-5019.5	5736
Kcnc3	3193.5	4194
Kcnd2	-1801.5	5545
Kcnd3	-381.5	4361
Kcng2	-5044.5	4262
Kcnh2	5013.5	4284
Kcnq1	824.5	4876
Kcnq4	-3437.5	-2543
Kcnv2	-3918.5	4393

---

---

SRP-dependent-cotranslational-protein-targeting-to-membrane

metric	value
setSize	92
pMANOVA	4.84e-16
p.adjustMANOVA	5.97e-14
s.dist	0.509
s.ab	0.043
s.d36	-0.507
p.ab	0.477
p.d36	4.57e-17

Gene	ab	d36
Rps23	5402.5	-5063
Rps20	5084.5	-5300
Rps4x	5645.5	-4580
Spcs2	4681.5	-5523
Rpl3	4229.5	-5770
Sec61b	4402.5	-5302
Tram1	4203.5	-5435
Rpl22	4995.5	-4324
Rpl26	4899.5	-4289
Rpl23	5208.5	-4021
Rpn2	4616.5	-4517
Rps3a1	4558.5	-4165
Rpl22l1	3523.5	-5282
Rpl4	5629.5	-3114
Rps6	5412.5	-3069
Rps24	4956.5	-3149
Rpl14	4942.5	-2991
Rps8	4049.5	-3452
Rps25	4129.5	-3204
Ssr1	4511.5	-2905

Click HERE to show all gene set members

	ab	d36
Ddost	2379.5	116
Flt3l	2020.5	-3039
Rpl10a	-1941.5	-4929
Rpl11	-2529.5	-3606
Rpl12	-3318.5	-2902
Rpl13	-5343.5	-4462
Rpl14	4942.5	-2991
Rpl15	-5749.5	-3305
Rpl18	-1996.5	-4127
Rpl18a	-1154.5	-3833
Rpl19	-1709.5	-4384
Rpl22	4995.5	-4324
Rpl22l1	3523.5	-5282
Rpl23	5208.5	-4021
Rpl23a	4038.5	-1192
Rpl24	2546.5	-3508
Rpl26	4899.5	-4289
Rpl27-ps3	5035.5	-2001
Rpl27a	-3414.5	-4219
Rpl28	-5186.5	-3868
Rpl29	-3224.5	-3135
Rpl3	4229.5	-5770
Rpl30	-3228.5	-4370
Rpl32	-3143.5	-4101
Rpl34	-3795.5	-3996
Rpl35	-3665.5	-3928
Rpl36al	-1509.5	-5050
Rpl37	-2597.5	-2588
Rpl37a	50.5	-4031
Rpl38	3088.5	-4166
Rpl39	1032.5	-4810
Rpl3l	-4110.5	2642
Rpl4	5629.5	-3114
Rpl41	-4354.5	-4635
Rpl5	-4969.5	-3931
Rpl6	1461.5	-3217
Rpl8	-883.5	-4630
Rplp0	-5643.5	-2660
Rplp1	-2371.5	-4419
Rplp2	-4360.5	-4986
Rpn1	-1826.5	-4195
Rpn2	4616.5	-4517
Rps11	392.5	-3904
Rps13	-495.5	-3412
Rps14	-186.5	-4375
Rps15a	-3535.5	-2229
Rps16	-3846.5	-5414
Rps17	-1442.5	-4621
Rps18	607.5	-4200
Rps19	-3084.5	-4163
Rps20	5084.5	-5300
Rps21	-2041.5	-3684
Rps23	5402.5	-5063
Rps24	4956.5	-3149
Rps25	4129.5	-3204
Rps26	2173.5	-4049
Rps27	1294.5	-4744
Rps27a	-4190.5	-4207
Rps27l	3129.5	-3066
Rps29	-684.5	-4455
Rps3	-321.5	-4333
Rps3a1	4558.5	-4165
Rps4x	5645.5	-4580
Rps5	-3589.5	-3763
Rps6	5412.5	-3069
Rps7	2833.5	-3831
Rps8	4049.5	-3452
Rps9	-1967.5	-4122
Rpsa	-1204.5	-4470
Sec11a	-4419.5	-1021
Sec11c	837.5	-5159
Sec61a1	1251.5	-619
Sec61a2	-2542.5	-1400
Sec61b	4402.5	-5302
Sec61g	-4711.5	-2153
Spcs1	4081.5	-2025
Spcs2	4681.5	-5523
Spcs3	-790.5	5570
Srp14	4462.5	-2858
Srp19	-2399.5	194
Srp54a	-1674.5	4489
Srp68	-3617.5	4648
Srp72	-2379.5	4447
Srp9	3704.5	232
Srpr	-5627.5	5043
Srprb	80.5	-128
Ssr1	4511.5	-2905
Ssr2	2079.5	-5247
Ssr3	3890.5	3297
Ssr4	3039.5	-3852
Tram1	4203.5	-5435
Uba52	-2952.5	-3903

---

---

G-beta:gamma-signalling-through-BTK

metric	value
setSize	11
pMANOVA	0.021
p.adjustMANOVA	0.0963
s.dist	0.508
s.ab	0.371
s.d36	-0.346
p.ab	0.0331
p.d36	0.0468

Gene	ab	d36
Gng2	5782.5	-5206
Gng10	5579.5	-4220
Gnb1	3791.5	-5197
Gnb4	3274.5	-5708
Gngt2	5414.5	-2034

Click HERE to show all gene set members

	ab	d36
Gnb1	3791.5	-5197
Gnb2	-5587.5	-3631
Gnb3	-88.5	-839
Gnb4	3274.5	-5708
Gnb5	1823.5	3790
Gng10	5579.5	-4220
Gng11	-2523.5	-1939
Gng12	3603.5	954
Gng2	5782.5	-5206
Gng5	1661.5	505
Gngt2	5414.5	-2034

---

---

Activation-of-G-protein-gated-Potassium-channels

metric	value
setSize	16
pMANOVA	0.00291
p.adjustMANOVA	0.021
s.dist	0.501
s.ab	0.491
s.d36	-0.1
p.ab	0.000676
p.d36	0.488

Gene	ab	d36
Gng2	5782.5	-5206
Gng10	5579.5	-4220
Gabbr1	5384.5	-3897
Gnb1	3791.5	-5197
Gnb4	3274.5	-5708
Gngt2	5414.5	-2034

Click HERE to show all gene set members

	ab	d36
Gabbr1	5384.5	-3897
Gnb1	3791.5	-5197
Gnb2	-5587.5	-3631
Gnb3	-88.5	-839
Gnb4	3274.5	-5708
Gnb5	1823.5	3790
Gng10	5579.5	-4220
Gng11	-2523.5	-1939
Gng12	3603.5	954
Gng2	5782.5	-5206
Gng5	1661.5	505
Gngt2	5414.5	-2034
Kcnj12	2820.5	4777
Kcnj2	2369.5	5757
Kcnj3	5610.5	1320
Kcnj5	5491.5	4706

---

---

G-protein-gated-Potassium-channels

metric	value
setSize	16
pMANOVA	0.00291
p.adjustMANOVA	0.021
s.dist	0.501
s.ab	0.491
s.d36	-0.1
p.ab	0.000676
p.d36	0.488

Gene	ab	d36
Gng2	5782.5	-5206
Gng10	5579.5	-4220
Gabbr1	5384.5	-3897
Gnb1	3791.5	-5197
Gnb4	3274.5	-5708
Gngt2	5414.5	-2034

Click HERE to show all gene set members

	ab	d36
Gabbr1	5384.5	-3897
Gnb1	3791.5	-5197
Gnb2	-5587.5	-3631
Gnb3	-88.5	-839
Gnb4	3274.5	-5708
Gnb5	1823.5	3790
Gng10	5579.5	-4220
Gng11	-2523.5	-1939
Gng12	3603.5	954
Gng2	5782.5	-5206
Gng5	1661.5	505
Gngt2	5414.5	-2034
Kcnj12	2820.5	4777
Kcnj2	2369.5	5757
Kcnj3	5610.5	1320
Kcnj5	5491.5	4706

---

---

Inhibition--of-voltage-gated-Ca2+-channels-via-Gbeta/gamma-subunits

metric	value
setSize	16
pMANOVA	0.00291
p.adjustMANOVA	0.021
s.dist	0.501
s.ab	0.491
s.d36	-0.1
p.ab	0.000676
p.d36	0.488

Gene	ab	d36
Gng2	5782.5	-5206
Gng10	5579.5	-4220
Gabbr1	5384.5	-3897
Gnb1	3791.5	-5197
Gnb4	3274.5	-5708
Gngt2	5414.5	-2034

Click HERE to show all gene set members

	ab	d36
Gabbr1	5384.5	-3897
Gnb1	3791.5	-5197
Gnb2	-5587.5	-3631
Gnb3	-88.5	-839
Gnb4	3274.5	-5708
Gnb5	1823.5	3790
Gng10	5579.5	-4220
Gng11	-2523.5	-1939
Gng12	3603.5	954
Gng2	5782.5	-5206
Gng5	1661.5	505
Gngt2	5414.5	-2034
Kcnj12	2820.5	4777
Kcnj2	2369.5	5757
Kcnj3	5610.5	1320
Kcnj5	5491.5	4706

---

---

Acyl-chain-remodelling-of-PE

metric	value
setSize	13
pMANOVA	0.00441
p.adjustMANOVA	0.0304
s.dist	0.501
s.ab	0.378
s.d36	0.328
p.ab	0.0182
p.d36	0.0407

Gene	ab	d36
Abhd4	5737.5	4289
Mboat2	5506.5	3712
Pnpla8	4906.5	4097
Pla2g4a	5119.5	1798
Pla2g4e	5800.5	1442
Pla2g12a	1398.5	2446

Click HERE to show all gene set members

	ab	d36
Abhd4	5737.5	4289
Lpcat3	-1378.5	5291
Lpcat4	1840.5	-4535
Mboat2	5506.5	3712
Pla2g12a	1398.5	2446
Pla2g4a	5119.5	1798
Pla2g4b	5743.5	-4162
Pla2g4e	5800.5	1442
Pla2g5	-1581.5	5797
Pla2g6	-4934.5	1748
Pla2r1	5094.5	-3462
Plbd1	-5828.5	5720
Pnpla8	4906.5	4097

---

---

G-protein-activation

metric	value
setSize	15
pMANOVA	0.00714
p.adjustMANOVA	0.043
s.dist	0.489
s.ab	0.414
s.d36	-0.26
p.ab	0.00549
p.d36	0.0813

Gene	ab	d36
Gng2	5782.5	-5206
Gng10	5579.5	-4220
Gnb1	3791.5	-5197
Gnb4	3274.5	-5708
Gngt2	5414.5	-2034
Gnai3	4769.5	-6

Click HERE to show all gene set members

	ab	d36
Gnai1	4876.5	1477
Gnai2	-2023.5	-2736
Gnai3	4769.5	-6
Gnao1	4461.5	391
Gnb1	3791.5	-5197
Gnb2	-5587.5	-3631
Gnb3	-88.5	-839
Gnb4	3274.5	-5708
Gnb5	1823.5	3790
Gng10	5579.5	-4220
Gng11	-2523.5	-1939
Gng12	3603.5	954
Gng2	5782.5	-5206
Gng5	1661.5	505
Gngt2	5414.5	-2034

---

---

Pyruvate-metabolism

metric	value
setSize	26
pMANOVA	0.000223
p.adjustMANOVA	0.00302
s.dist	0.484
s.ab	-0.246
s.d36	0.417
p.ab	0.0301
p.d36	0.000234

Gene	ab	d36
Rxra	-5660.5	4852
Pdk2	-4667.5	5542
Me1	-4151.5	5434
Pdp1	-3944.5	5660
Vdac1	-3120.5	5253
Ppard	-3952.5	3976
Pdk4	-2607.5	5541
Pdp2	-2320.5	5623
Dlat	-1788.5	3921
Pdha1	-1301.5	4866
Pdpr	-1393.5	3743
Pdk1	-838.5	4653
Slc16a1	-3831.5	892
Bsg	-3352.5	403
Mpc1	-2394.5	440
Ldhb	-1477.5	532
Dld	-74.5	4418
Pdhb	-242.5	1105

Click HERE to show all gene set members

	ab	d36
Bsg	-3352.5	403
Dlat	-1788.5	3921
Dld	-74.5	4418
Glo1	538.5	2947
Gstz1	4779.5	2839
Hagh	-3951.5	-2989
Ldha	-4261.5	-1535
Ldhb	-1477.5	532
Me1	-4151.5	5434
Mpc1	-2394.5	440
Mpc2	-2713.5	-1034
Pdha1	-1301.5	4866
Pdhb	-242.5	1105
Pdhx	2159.5	1148
Pdk1	-838.5	4653
Pdk2	-4667.5	5542
Pdk3	5741.5	-572
Pdk4	-2607.5	5541
Pdp1	-3944.5	5660
Pdp2	-2320.5	5623
Pdpr	-1393.5	3743
Ppard	-3952.5	3976
Rxra	-5660.5	4852
Slc16a1	-3831.5	892
Slc16a3	3452.5	-5626
Vdac1	-3120.5	5253

---

---

Collagen-chain-trimerization

metric	value
setSize	25
pMANOVA	9.17e-05
p.adjustMANOVA	0.00157
s.dist	0.483
s.ab	-0.135
s.d36	-0.464
p.ab	0.244
p.d36	5.97e-05

Gene	ab	d36
Col20a1	-4825.5	-5211
Col4a1	-4700.5	-4897
Col6a6	-5765.5	-3954
Col4a2	-5585.5	-3480
Col11a2	-4820.5	-3718
Col6a3	-5704.5	-2843
Col27a1	-4292.5	-3531
Col15a1	-3240.5	-4013
Col6a2	-2323.5	-5510
Col6a1	-2301.5	-5407
Col5a3	-2642.5	-3213
Col16a1	-952.5	-5719
Col5a1	-1031.5	-4402
Col8a1	-4520.5	-564
Col3a1	-1219.5	-1922
Col1a1	-571.5	-1205

Click HERE to show all gene set members

	ab	d36
Col11a2	-4820.5	-3718
Col14a1	3297.5	1153
Col15a1	-3240.5	-4013
Col16a1	-952.5	-5719
Col18a1	5581.5	-4573
Col1a1	-571.5	-1205
Col1a2	585.5	-2063
Col20a1	-4825.5	-5211
Col23a1	5731.5	2306
Col27a1	-4292.5	-3531
Col3a1	-1219.5	-1922
Col4a1	-4700.5	-4897
Col4a2	-5585.5	-3480
Col4a3	583.5	-4381
Col4a4	4684.5	-4085
Col4a5	3292.5	2171
Col4a6	5622.5	92
Col5a1	-1031.5	-4402
Col5a2	1784.5	-1848
Col5a3	-2642.5	-3213
Col6a1	-2301.5	-5407
Col6a2	-2323.5	-5510
Col6a3	-5704.5	-2843
Col6a6	-5765.5	-3954
Col8a1	-4520.5	-564

---

---

ADP-signalling-through-P2Y-purinoceptor-12

metric	value
setSize	14
pMANOVA	0.0118
p.adjustMANOVA	0.0634
s.dist	0.481
s.ab	0.388
s.d36	-0.284
p.ab	0.0119
p.d36	0.0655

Gene	ab	d36
Gng2	5782.5	-5206
Gng10	5579.5	-4220
Gnb1	3791.5	-5197
Gnb4	3274.5	-5708
Gngt2	5414.5	-2034
Gnai3	4769.5	-6

Click HERE to show all gene set members

	ab	d36
Gnai1	4876.5	1477
Gnai2	-2023.5	-2736
Gnai3	4769.5	-6
Gnb1	3791.5	-5197
Gnb2	-5587.5	-3631
Gnb3	-88.5	-839
Gnb4	3274.5	-5708
Gnb5	1823.5	3790
Gng10	5579.5	-4220
Gng11	-2523.5	-1939
Gng12	3603.5	954
Gng2	5782.5	-5206
Gng5	1661.5	505
Gngt2	5414.5	-2034

---

---

Thrombin-signalling-through-proteinase-activated-receptors-(PARs)

metric	value
setSize	21
pMANOVA	0.00137
p.adjustMANOVA	0.0116
s.dist	0.48
s.ab	0.336
s.d36	-0.343
p.ab	0.00764
p.d36	0.00656

Gene	ab	d36
Gng2	5782.5	-5206
F2r	5371.5	-5362
Gng10	5579.5	-4220
Gnb1	3791.5	-5197
Gnb4	3274.5	-5708
Arrb1	3464.5	-5200
Src	5217.5	-2972
Gngt2	5414.5	-2034
Arrb2	1118.5	-3266
Mapk3	435.5	-5175
Gnaq	425.5	-2832
Gna13	47.5	-635

Click HERE to show all gene set members

	ab	d36
Arrb1	3464.5	-5200
Arrb2	1118.5	-3266
F2r	5371.5	-5362
Gna11	-3119.5	-3588
Gna12	970.5	4107
Gna13	47.5	-635
Gnaq	425.5	-2832
Gnb1	3791.5	-5197
Gnb2	-5587.5	-3631
Gnb3	-88.5	-839
Gnb4	3274.5	-5708
Gnb5	1823.5	3790
Gng10	5579.5	-4220
Gng11	-2523.5	-1939
Gng12	3603.5	954
Gng2	5782.5	-5206
Gng5	1661.5	505
Gngt2	5414.5	-2034
Mapk1	2361.5	4015
Mapk3	435.5	-5175
Src	5217.5	-2972

---

---

Interleukin-7-signaling

metric	value
setSize	15
pMANOVA	0.00926
p.adjustMANOVA	0.0527
s.dist	0.478
s.ab	-0.375
s.d36	0.296
p.ab	0.0119
p.d36	0.0473

Gene	ab	d36
Jak1	-5522.5	3290
Smarca4	-4251.5	4134
Irs1	-6067.5	2770
Stat5a	-2873.5	5707
Pik3r1	-2910.5	4811
Cish	-6028.5	2049
Irs2	-6024.5	528
Brwd1	-2526.5	1177
Pik3r3	-407.5	5080
Pik3r2	-347.5	2632

Click HERE to show all gene set members

	ab	d36
Brwd1	-2526.5	1177
Cish	-6028.5	2049
Crlf2	480.5	-5715
Irs1	-6067.5	2770
Irs2	-6024.5	528
Jak1	-5522.5	3290
Jak3	-4806.5	-2877
Pik3r1	-2910.5	4811
Pik3r2	-347.5	2632
Pik3r3	-407.5	5080
Smarca4	-4251.5	4134
Socs2	-121.5	-3402
Stat3	3357.5	2307
Stat5a	-2873.5	5707
Stat5b	2646.5	2564

---

---

Selenoamino-acid-metabolism

metric	value
setSize	90
pMANOVA	2.44e-14
p.adjustMANOVA	2.51e-12
s.dist	0.478
s.ab	-0.0307
s.d36	-0.477
p.ab	0.616
p.d36	5.65e-15

Gene	ab	d36
Aimp2	-5750.5	-5216
Rpl13	-5343.5	-4462
Rplp2	-4360.5	-4986
Rps16	-3846.5	-5414
Rpl41	-4354.5	-4635
Rpl28	-5186.5	-3868
Rpl5	-4969.5	-3931
Rpl15	-5749.5	-3305
Rps27a	-4190.5	-4207
Rpl34	-3795.5	-3996
Rplp0	-5643.5	-2660
Rpl27a	-3414.5	-4219
Rpl35	-3665.5	-3928
Rpl30	-3228.5	-4370
Rps5	-3589.5	-3763
Rpl32	-3143.5	-4101
Rps19	-3084.5	-4163
Uba52	-2952.5	-3903
Rplp1	-2371.5	-4419
Rpl29	-3224.5	-3135

Click HERE to show all gene set members

	ab	d36
Ahcy	-1307.5	-1303
Aimp1	1129.5	-3521
Aimp2	-5750.5	-5216
Dars	-4369.5	1335
Eefsec	-894.5	-2973
Eprs	-2478.5	-837
Flt3l	2020.5	-3039
Gsr	55.5	2035
Hnmt	5306.5	5055
Iars	-5826.5	3615
Inmt	4854.5	-1704
Lars	-3917.5	2785
Mars	-5670.5	1573
Papss1	4509.5	-5279
Papss2	4802.5	-4026
Pstk	-4403.5	5239
Qars	-912.5	4779
Rars	1411.5	-2046
Rpl10a	-1941.5	-4929
Rpl11	-2529.5	-3606
Rpl12	-3318.5	-2902
Rpl13	-5343.5	-4462
Rpl14	4942.5	-2991
Rpl15	-5749.5	-3305
Rpl18	-1996.5	-4127
Rpl18a	-1154.5	-3833
Rpl19	-1709.5	-4384
Rpl22	4995.5	-4324
Rpl22l1	3523.5	-5282
Rpl23	5208.5	-4021
Rpl23a	4038.5	-1192
Rpl24	2546.5	-3508
Rpl26	4899.5	-4289
Rpl27-ps3	5035.5	-2001
Rpl27a	-3414.5	-4219
Rpl28	-5186.5	-3868
Rpl29	-3224.5	-3135
Rpl3	4229.5	-5770
Rpl30	-3228.5	-4370
Rpl32	-3143.5	-4101
Rpl34	-3795.5	-3996
Rpl35	-3665.5	-3928
Rpl36al	-1509.5	-5050
Rpl37	-2597.5	-2588
Rpl37a	50.5	-4031
Rpl38	3088.5	-4166
Rpl39	1032.5	-4810
Rpl3l	-4110.5	2642
Rpl4	5629.5	-3114
Rpl41	-4354.5	-4635
Rpl5	-4969.5	-3931
Rpl6	1461.5	-3217
Rpl8	-883.5	-4630
Rplp0	-5643.5	-2660
Rplp1	-2371.5	-4419
Rplp2	-4360.5	-4986
Rps11	392.5	-3904
Rps13	-495.5	-3412
Rps14	-186.5	-4375
Rps15a	-3535.5	-2229
Rps16	-3846.5	-5414
Rps17	-1442.5	-4621
Rps18	607.5	-4200
Rps19	-3084.5	-4163
Rps20	5084.5	-5300
Rps21	-2041.5	-3684
Rps23	5402.5	-5063
Rps24	4956.5	-3149
Rps25	4129.5	-3204
Rps26	2173.5	-4049
Rps27	1294.5	-4744
Rps27a	-4190.5	-4207
Rps27l	3129.5	-3066
Rps29	-684.5	-4455
Rps3	-321.5	-4333
Rps3a1	4558.5	-4165
Rps4x	5645.5	-4580
Rps5	-3589.5	-3763
Rps6	5412.5	-3069
Rps7	2833.5	-3831
Rps8	4049.5	-3452
Rps9	-1967.5	-4122
Rpsa	-1204.5	-4470
Sars	-5060.5	575
Scly	-943.5	-5072
Secisbp2	-4620.5	857
Sephs2	4892.5	-4752
Sepsecs	3483.5	1508
Txnrd1	-5335.5	5116
Uba52	-2952.5	-3903

---

---

G-beta:gamma-signalling-through-CDC42

metric	value
setSize	13
pMANOVA	0.0179
p.adjustMANOVA	0.0854
s.dist	0.477
s.ab	0.326
s.d36	-0.348
p.ab	0.0419
p.d36	0.0299

Gene	ab	d36
Gng2	5782.5	-5206
Cdc42	4469.5	-5470
Gng10	5579.5	-4220
Gnb1	3791.5	-5197
Gnb4	3274.5	-5708
Gngt2	5414.5	-2034

Click HERE to show all gene set members

	ab	d36
Arhgef6	-3829.5	1076
Cdc42	4469.5	-5470
Gnb1	3791.5	-5197
Gnb2	-5587.5	-3631
Gnb3	-88.5	-839
Gnb4	3274.5	-5708
Gnb5	1823.5	3790
Gng10	5579.5	-4220
Gng11	-2523.5	-1939
Gng12	3603.5	954
Gng2	5782.5	-5206
Gng5	1661.5	505
Gngt2	5414.5	-2034

---

---

G-beta:gamma-signalling-through-PLC-beta

metric	value
setSize	14
pMANOVA	0.0123
p.adjustMANOVA	0.0652
s.dist	0.476
s.ab	0.422
s.d36	-0.22
p.ab	0.00627
p.d36	0.155

Gene	ab	d36
Gng2	5782.5	-5206
Gng10	5579.5	-4220
Gnb1	3791.5	-5197
Gnb4	3274.5	-5708
Gngt2	5414.5	-2034
Plcb3	3157.5	-1110

Click HERE to show all gene set members

	ab	d36
Gnb1	3791.5	-5197
Gnb2	-5587.5	-3631
Gnb3	-88.5	-839
Gnb4	3274.5	-5708
Gnb5	1823.5	3790
Gng10	5579.5	-4220
Gng11	-2523.5	-1939
Gng12	3603.5	954
Gng2	5782.5	-5206
Gng5	1661.5	505
Gngt2	5414.5	-2034
Plcb1	2787.5	2077
Plcb2	4464.5	3151
Plcb3	3157.5	-1110

---

---

Presynaptic-function-of-Kainate-receptors

metric	value
setSize	14
pMANOVA	0.0123
p.adjustMANOVA	0.0652
s.dist	0.476
s.ab	0.422
s.d36	-0.22
p.ab	0.00627
p.d36	0.155

Gene	ab	d36
Gng2	5782.5	-5206
Gng10	5579.5	-4220
Gnb1	3791.5	-5197
Gnb4	3274.5	-5708
Gngt2	5414.5	-2034
Plcb3	3157.5	-1110

Click HERE to show all gene set members

	ab	d36
Gnb1	3791.5	-5197
Gnb2	-5587.5	-3631
Gnb3	-88.5	-839
Gnb4	3274.5	-5708
Gnb5	1823.5	3790
Gng10	5579.5	-4220
Gng11	-2523.5	-1939
Gng12	3603.5	954
Gng2	5782.5	-5206
Gng5	1661.5	505
Gngt2	5414.5	-2034
Plcb1	2787.5	2077
Plcb2	4464.5	3151
Plcb3	3157.5	-1110

---

---

Basigin-interactions

metric	value
setSize	18
pMANOVA	0.00417
p.adjustMANOVA	0.0291
s.dist	0.473
s.ab	0.343
s.d36	-0.326
p.ab	0.0118
p.d36	0.0168

Gene	ab	d36
Cav1	4754.5	-5886
Slc3a2	4587.5	-5542
Atp1b3	5168.5	-4262
Slc7a6	4648.5	-4568
Slc16a3	3452.5	-5626
Atp1b2	3667.5	-5273
Slc7a5	4006.5	-3723
Slc7a7	5746.5	-1805
Ppia	808.5	-4794

Click HERE to show all gene set members

	ab	d36
Atp1b1	-150.5	3208
Atp1b2	3667.5	-5273
Atp1b3	5168.5	-4262
Bsg	-3352.5	403
Cav1	4754.5	-5886
Itga3	4396.5	2383
Itga6	-4134.5	-5495
Itgb1	3540.5	3163
L1cam	-2382.5	-3142
Ppia	808.5	-4794
Ppil2	-2307.5	2412
Slc16a1	-3831.5	892
Slc16a3	3452.5	-5626
Slc3a2	4587.5	-5542
Slc7a5	4006.5	-3723
Slc7a6	4648.5	-4568
Slc7a7	5746.5	-1805
Slc7a8	5528.5	1390

---

---

Synthesis-of-Prostaglandins-(PG)-and-Thromboxanes-(TX)

metric	value
setSize	10
pMANOVA	0.0482
p.adjustMANOVA	0.171
s.dist	0.472
s.ab	0.351
s.d36	-0.315
p.ab	0.0548
p.d36	0.0846

Gene	ab	d36
Ptgs1	5675.5	-5659
Hpgd	5437.5	-4846
Ptgis	5113.5	-3525
Ptgds	4911.5	-2326
Tbxas1	1684.5	-3037
Akr1c14	2174.5	-1600

Click HERE to show all gene set members

	ab	d36
Akr1c14	2174.5	-1600
Cbr1	2721.5	1075
Hpgd	5437.5	-4846
Ptgds	4911.5	-2326
Ptges2	-1183.5	234
Ptges3	-4640.5	-2970
Ptgis	5113.5	-3525
Ptgr2	-2432.5	3120
Ptgs1	5675.5	-5659
Tbxas1	1684.5	-3037

---

---

Interferon-alpha/beta-signaling

metric	value
setSize	35
pMANOVA	4.73e-06
p.adjustMANOVA	0.000133
s.dist	0.468
s.ab	-0.144
s.d36	-0.445
p.ab	0.141
p.d36	5.18e-06

Gene	ab	d36
Bst2	-5888.5	-5996
Isg15	-5883.5	-5285
Oas2	-5540.5	-4990
Irf7	-4647.5	-5914
Rsad2	-5131.5	-4843
Stat2	-4139.5	-5921
Isg20	-5441.5	-3741
Ifi35	-4428.5	-4434
Irf2	-5873.5	-3194
Ifnar1	-2630.5	-5833
Usp18	-5444.5	-1927
Ifnar2	-2806.5	-3629
Ptpn6	-4724.5	-2054
Psmb8	-2315.5	-3885
Xaf1	-1862.5	-3693
Ifit2	-2736.5	-2298
Irf3	-1680.5	-2895
Irf8	-1276.5	-2982
Samhd1	-555.5	-1960

Click HERE to show all gene set members

	ab	d36
Abce1	-4552.5	2319
Adar	1807.5	-4432
Bst2	-5888.5	-5996
Egr1	4846.5	-1350
Ifi27	5358.5	-3694
Ifi35	-4428.5	-4434
Ifit2	-2736.5	-2298
Ifit3	3876.5	-1636
Ifnar1	-2630.5	-5833
Ifnar2	-2806.5	-3629
Ip6k2	4775.5	586
Irf1	3743.5	-4308
Irf2	-5873.5	-3194
Irf3	-1680.5	-2895
Irf5	3395.5	-3826
Irf7	-4647.5	-5914
Irf8	-1276.5	-2982
Irf9	1471.5	-5883
Isg15	-5883.5	-5285
Isg20	-5441.5	-3741
Jak1	-5522.5	3290
Oas2	-5540.5	-4990
Psmb8	-2315.5	-3885
Ptpn1	1809.5	-279
Ptpn11	1827.5	1935
Ptpn6	-4724.5	-2054
Rnasel	5083.5	-3416
Rsad2	-5131.5	-4843
Samhd1	-555.5	-1960
Socs3	3467.5	3794
Stat1	3505.5	-7
Stat2	-4139.5	-5921
Tyk2	3595.5	-2825
Usp18	-5444.5	-1927
Xaf1	-1862.5	-3693

---

---

Metabolism-of-nitric-oxide:-eNOS-activation-and-regulation

metric	value
setSize	15
pMANOVA	0.00648
p.adjustMANOVA	0.0398
s.dist	0.467
s.ab	-0.0461
s.d36	-0.464
p.ab	0.757
p.d36	0.00185

Gene	ab	d36
Cygb	-2389.5	-4825
Nostrin	-2021.5	-5623
Dnm2	-4101.5	-2206
Akt1	-4927.5	-1552
Hsp90aa1	-668.5	-4565
Ddah2	-24.5	-2037

Click HERE to show all gene set members

	ab	d36
Akt1	-4927.5	-1552
Calm1	1392.5	-5536
Cav1	4754.5	-5886
Cygb	-2389.5	-4825
Ddah1	-4911.5	1178
Ddah2	-24.5	-2037
Dnm2	-4101.5	-2206
Hsp90aa1	-668.5	-4565
Lypla1	-35.5	2373
Nos3	3513.5	-5802
Nosip	2634.5	-2132
Nostrin	-2021.5	-5623
Spr	602.5	-3175
Wasl	-1485.5	2711
Zdhhc21	1540.5	-5484

---

---

MECP2-regulates-neuronal-receptors-and-channels

metric	value
setSize	11
pMANOVA	0.0263
p.adjustMANOVA	0.113
s.dist	0.463
s.ab	0.462
s.d36	0.0407
p.ab	0.00803
p.d36	0.815

Gene	ab	d36
Ptpn4	5576.5	4306
Slc2a3	3495.5	1915
Hdac2	4934.5	618
Sin3a	2117.5	948
Mecp2	153.5	4573

Click HERE to show all gene set members

	ab	d36
Creb1	-4202.5	2261
Fkbp5	5664.5	-4095
Hdac1	5680.5	-2077
Hdac2	4934.5	618
Mecp2	153.5	4573
Notch1	2890.5	-3995
Ptpn1	1809.5	-279
Ptpn4	5576.5	4306
Sin3a	2117.5	948
Slc2a3	3495.5	1915
Trpc3	517.5	-2446

---

---

Caspase-mediated-cleavage-of-cytoskeletal-proteins

metric	value
setSize	12
pMANOVA	0.023
p.adjustMANOVA	0.102
s.dist	0.462
s.ab	0.0607
s.d36	-0.458
p.ab	0.716
p.d36	0.00604

Gene	ab	d36
Vim	3629.5	-5658
Sptan1	3007.5	-5334
Casp3	2412.5	-4726
Casp6	4496.5	-1394
Casp8	944.5	-5712
Gsn	101.5	-4747

Click HERE to show all gene set members

	ab	d36
Add1	1065.5	5204
Casp3	2412.5	-4726
Casp6	4496.5	-1394
Casp7	-1335.5	-3120
Casp8	944.5	-5712
Dbnl	-4869.5	-5726
Gas2	4279.5	780
Gsn	101.5	-4747
Mapt	-4962.5	-4883
Plec	-6071.5	1721
Sptan1	3007.5	-5334
Vim	3629.5	-5658

---

---

Scavenging-by-Class-A-Receptors

metric	value
setSize	14
pMANOVA	0.00767
p.adjustMANOVA	0.0455
s.dist	0.461
s.ab	-0.215
s.d36	-0.407
p.ab	0.163
p.d36	0.00832

Gene	ab	d36
Ftl1	-5672.5	-4192
Col4a1	-4700.5	-4897
Col4a2	-5585.5	-3480
Colec11	-1030.5	-5627
Scara5	-1328.5	-1894
Calr	-1179.5	-2120
Col3a1	-1219.5	-1922
Fth1	-2174.5	-393
Col1a1	-571.5	-1205

Click HERE to show all gene set members

	ab	d36
Apoe	1800.5	-5065
Calr	-1179.5	-2120
Col1a1	-571.5	-1205
Col1a2	585.5	-2063
Col3a1	-1219.5	-1922
Col4a1	-4700.5	-4897
Col4a2	-5585.5	-3480
Colec11	-1030.5	-5627
Colec12	4327.5	-2758
Fth1	-2174.5	-393
Ftl1	-5672.5	-4192
Hsp90b1	1963.5	-1630
Masp1	-4978.5	2243
Scara5	-1328.5	-1894

---

---

Peroxisomal-protein-import

metric	value
setSize	52
pMANOVA	1.8e-07
p.adjustMANOVA	7.16e-06
s.dist	0.46
s.ab	-0.157
s.d36	0.432
p.ab	0.0507
p.d36	7.11e-08

Gene	ab	d36
Dhrs4	-4704.5	5203
Ube2d1	-4742.5	4771
Acot2	-3528.5	5594
Nudt7	-3329.5	5773
Crat	-2926.5	5772
Mlycd	-2975.5	5299
Idh1	-3045.5	5095
Ide	-2882.5	5146
Amacr	-2719.5	5193
Pex12	-2684.5	4723
Crot	-2245.5	4979
Pex7	-1753.5	5164
Paox	-4685.5	1842
Pex6	-4277.5	1581
Pex2	-4600.5	1444
Ddo	-1129.5	5697
Ephx2	-1020.5	5848
Hacl1	-2104.5	2166
Hmgcl	-2497.5	1687
Ech1	-4002.5	938

Click HERE to show all gene set members

	ab	d36
Acot2	-3528.5	5594
Acot4	1084.5	-125
Acot8	-3903.5	-1738
Acox1	1182.5	5457
Acox3	3081.5	2431
Agps	-2340.5	-440
Amacr	-2719.5	5193
Cat	95.5	5567
Crat	-2926.5	5772
Crot	-2245.5	4979
Ddo	-1129.5	5697
Decr2	359.5	-2504
Dhrs4	-4704.5	5203
Ech1	-4002.5	938
Ehhadh	2146.5	5711
Ephx2	-1020.5	5848
Gnpat	1173.5	4973
Gstk1	-1153.5	124
Hacl1	-2104.5	2166
Hmgcl	-2497.5	1687
Hsd17b4	273.5	4650
Ide	-2882.5	5146
Idh1	-3045.5	5095
Lonp2	-493.5	5405
Mlycd	-2975.5	5299
Mpv17	-3580.5	-623
Nos2	-4783.5	-5692
Nudt19	4961.5	1526
Nudt7	-3329.5	5773
Paox	-4685.5	1842
Pecr	1658.5	-575
Pex1	4455.5	3578
Pex10	321.5	3276
Pex12	-2684.5	4723
Pex13	4063.5	2706
Pex14	248.5	1366
Pex2	-4600.5	1444
Pex26	323.5	421
Pex5	-5172.5	-197
Pex6	-4277.5	1581
Pex7	-1753.5	5164
Phyh	1979.5	4810
Rps27a	-4190.5	-4207
Scp2	5674.5	2752
Tysnd1	-1743.5	497
Uba52	-2952.5	-3903
Ubb	-2267.5	-1407
Ube2d1	-4742.5	4771
Ube2d2a	5601.5	-410
Ube2d3	-1398.5	2087
Usp9x	2232.5	4874
Zfand6	-296.5	4130

---

---

Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)

metric	value
setSize	92
pMANOVA	3.46e-13
p.adjustMANOVA	2.84e-11
s.dist	0.455
s.ab	-0.00187
s.d36	-0.455
p.ab	0.975
p.d36	4.91e-14

Gene	ab	d36
Rpl13	-5343.5	-4462
Rplp2	-4360.5	-4986
Rps16	-3846.5	-5414
Rpl41	-4354.5	-4635
Rpl28	-5186.5	-3868
Rpl5	-4969.5	-3931
Rpl15	-5749.5	-3305
Rps27a	-4190.5	-4207
Rpl34	-3795.5	-3996
Rplp0	-5643.5	-2660
Rpl27a	-3414.5	-4219
Rpl35	-3665.5	-3928
Rpl30	-3228.5	-4370
Rps5	-3589.5	-3763
Rpl32	-3143.5	-4101
Rps19	-3084.5	-4163
Uba52	-2952.5	-3903
Rplp1	-2371.5	-4419
Rpl29	-3224.5	-3135
Rpl12	-3318.5	-2902

Click HERE to show all gene set members

	ab	d36
Casc3	-4271.5	-1111
Dcp1a	3413.5	-4671
Eif4a3	2916.5	-2359
Eif4g1	-2207.5	3277
Etf1	-2724.5	2042
Flt3l	2020.5	-3039
Gspt1	-3382.5	2577
Magoh	-3961.5	-1683
Magohb	-3534.5	-2051
Ncbp1	-1856.5	-2759
Ncbp2	335.5	-250
Pnrc2	5361.5	-2890
Ppp2ca	1855.5	200
Ppp2r1a	-2019.5	2680
Ppp2r2a	-2405.5	2903
Rnps1	-1184.5	1620
Rpl10a	-1941.5	-4929
Rpl11	-2529.5	-3606
Rpl12	-3318.5	-2902
Rpl13	-5343.5	-4462
Rpl14	4942.5	-2991
Rpl15	-5749.5	-3305
Rpl18	-1996.5	-4127
Rpl18a	-1154.5	-3833
Rpl19	-1709.5	-4384
Rpl22	4995.5	-4324
Rpl22l1	3523.5	-5282
Rpl23	5208.5	-4021
Rpl23a	4038.5	-1192
Rpl24	2546.5	-3508
Rpl26	4899.5	-4289
Rpl27-ps3	5035.5	-2001
Rpl27a	-3414.5	-4219
Rpl28	-5186.5	-3868
Rpl29	-3224.5	-3135
Rpl3	4229.5	-5770
Rpl30	-3228.5	-4370
Rpl32	-3143.5	-4101
Rpl34	-3795.5	-3996
Rpl35	-3665.5	-3928
Rpl36al	-1509.5	-5050
Rpl37	-2597.5	-2588
Rpl37a	50.5	-4031
Rpl38	3088.5	-4166
Rpl39	1032.5	-4810
Rpl3l	-4110.5	2642
Rpl4	5629.5	-3114
Rpl41	-4354.5	-4635
Rpl5	-4969.5	-3931
Rpl6	1461.5	-3217
Rpl8	-883.5	-4630
Rplp0	-5643.5	-2660
Rplp1	-2371.5	-4419
Rplp2	-4360.5	-4986
Rps11	392.5	-3904
Rps13	-495.5	-3412
Rps14	-186.5	-4375
Rps15a	-3535.5	-2229
Rps16	-3846.5	-5414
Rps17	-1442.5	-4621
Rps18	607.5	-4200
Rps19	-3084.5	-4163
Rps20	5084.5	-5300
Rps21	-2041.5	-3684
Rps23	5402.5	-5063
Rps24	4956.5	-3149
Rps25	4129.5	-3204
Rps26	2173.5	-4049
Rps27	1294.5	-4744
Rps27a	-4190.5	-4207
Rps27l	3129.5	-3066
Rps29	-684.5	-4455
Rps3	-321.5	-4333
Rps3a1	4558.5	-4165
Rps4x	5645.5	-4580
Rps5	-3589.5	-3763
Rps6	5412.5	-3069
Rps7	2833.5	-3831
Rps8	4049.5	-3452
Rps9	-1967.5	-4122
Rpsa	-1204.5	-4470
Smg1	-411.5	-4204
Smg5	818.5	4017
Smg6	-299.5	5247
Smg7	3889.5	-84
Smg8	-4635.5	2270
Smg9	-1571.5	-5550
Uba52	-2952.5	-3903
Upf1	-675.5	1867
Upf2	5290.5	757
Upf3a	-373.5	2500
Upf3b	5572.5	-497

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.0 (2020-04-24)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /mnt/md0/app/R-4.0.0/lib/libRblas.so
## LAPACK: /mnt/md0/app/R-4.0.0/lib/libRlapack.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_1.5.0               
##  [3] ggplot2_3.3.1               reshape2_1.4.4             
##  [5] beeswarm_0.2.3              gplots_3.0.3               
##  [7] gtools_3.8.2                tibble_3.0.1               
##  [9] dplyr_1.0.0                 echarts4r_0.2.3            
## [11] mitch_1.0.4                 DESeq2_1.28.1              
## [13] SummarizedExperiment_1.18.1 DelayedArray_0.14.0        
## [15] matrixStats_0.56.0          Biobase_2.48.0             
## [17] GenomicRanges_1.40.0        GenomeInfoDb_1.24.0        
## [19] IRanges_2.22.2              S4Vectors_0.26.1           
## [21] BiocGenerics_0.34.0        
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-6           bit64_0.9-7            RColorBrewer_1.1-2    
##  [4] rprojroot_1.3-2        tools_4.0.0            backports_1.1.7       
##  [7] R6_2.4.1               KernSmooth_2.23-17     DBI_1.1.0             
## [10] colorspace_1.4-1       withr_2.2.0            tidyselect_1.1.0      
## [13] gridExtra_2.3          bit_1.1-15.2           compiler_4.0.0        
## [16] desc_1.2.0             labeling_0.3           caTools_1.18.0        
## [19] scales_1.1.1           genefilter_1.70.0      stringr_1.4.0         
## [22] digest_0.6.25          rmarkdown_2.2          XVector_0.28.0        
## [25] pkgconfig_2.0.3        htmltools_0.4.0        fastmap_1.0.1         
## [28] highr_0.8              htmlwidgets_1.5.1      rlang_0.4.6           
## [31] RSQLite_2.2.0          shiny_1.4.0.2          farver_2.0.3          
## [34] generics_0.0.2         jsonlite_1.6.1         BiocParallel_1.22.0   
## [37] RCurl_1.98-1.2         magrittr_1.5           GenomeInfoDbData_1.2.3
## [40] Matrix_1.2-18          Rcpp_1.0.4.6           munsell_0.5.0         
## [43] lifecycle_0.2.0        stringi_1.4.6          yaml_2.2.1            
## [46] MASS_7.3-51.6          zlibbioc_1.34.0        plyr_1.8.6            
## [49] grid_4.0.0             blob_1.2.1             gdata_2.18.0          
## [52] promises_1.1.0         crayon_1.3.4           lattice_0.20-41       
## [55] splines_4.0.0          annotate_1.66.0        locfit_1.5-9.4        
## [58] knitr_1.28             pillar_1.4.4           geneplotter_1.66.0    
## [61] XML_3.99-0.3           glue_1.4.1             evaluate_0.14         
## [64] vctrs_0.3.0            httpuv_1.5.3.1         testthat_2.3.2        
## [67] gtable_0.3.0           purrr_0.3.4            reshape_0.8.8         
## [70] assertthat_0.2.1       xfun_0.14              mime_0.9              
## [73] xtable_1.8-4           later_1.0.0            survival_3.1-12       
## [76] pbmcapply_1.5.0        AnnotationDbi_1.50.0   memoise_1.1.0         
## [79] ellipsis_0.3.1

END of report