date generated: 2026-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
logFC
MAPK1 4.197978
ENTPD5 3.137454
ARRB1 3.119861
WDR44 2.946684
CDHR5 2.854538
CA3 2.845683

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1839
num_genes_in_profile 904
duplicated_genes_present 0
num_profile_genes_in_sets 749
num_profile_genes_not_in_sets 155

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1839
num_genesets_excluded 1507
num_genesets_included 332

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
REACTOME METABOLISM OF LIPIDS 30 0.00174 -0.335 0.423
REACTOME PEPTIDE HORMONE METABOLISM 15 0.00405 0.432 0.423
REACTOME FORMATION OF THE CORNIFIED ENVELOPE 28 0.00411 0.318 0.423
REACTOME KERATINIZATION 28 0.00411 0.318 0.423
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN 10 0.00444 -0.522 0.423
REACTOME SYNDECAN INTERACTIONS 10 0.00535 -0.511 0.423
REACTOME DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 9 0.00594 -0.532 0.423
REACTOME NON INTEGRIN MEMBRANE ECM INTERACTIONS 19 0.00660 -0.363 0.423
REACTOME NEUTROPHIL DEGRANULATION 152 0.00742 0.137 0.423
REACTOME MITOCHONDRIAL PROTEIN DEGRADATION 6 0.00914 -0.616 0.450
REACTOME EPHA MEDIATED GROWTH CONE COLLAPSE 7 0.01040 -0.561 0.450
REACTOME INNATE IMMUNE SYSTEM 266 0.01070 0.108 0.450
REACTOME ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 5 0.01230 0.648 0.450
REACTOME ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 5 0.01230 0.648 0.450
REACTOME RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 5 0.01780 -0.613 0.586
REACTOME DISEASES OF CARBOHYDRATE METABOLISM 6 0.01900 0.555 0.586
REACTOME CELLULAR RESPONSES TO STIMULI 87 0.01940 -0.152 0.586
REACTOME RHOBTB GTPASE CYCLE 8 0.02170 -0.471 0.597
REACTOME COMPLEMENT CASCADE 80 0.02250 0.154 0.597
REACTOME SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 70 0.02440 -0.162 0.597
REACTOME MUSCLE CONTRACTION 16 0.02580 -0.325 0.597
REACTOME EPH EPHRIN SIGNALING 20 0.02600 -0.291 0.597
REACTOME SCAVENGING BY CLASS B RECEPTORS 7 0.02870 -0.479 0.597
REACTOME LYSOSOME VESICLE BIOGENESIS 6 0.02950 0.515 0.597
REACTOME FOLDING OF ACTIN BY CCT TRIC 6 0.02970 -0.514 0.597
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 6 0.03240 -0.506 0.597
REACTOME SENSORY PROCESSING OF SOUND 5 0.03250 -0.554 0.597
REACTOME PHOSPHOLIPID METABOLISM 5 0.03350 -0.551 0.597
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 10 0.03470 -0.388 0.597
REACTOME MITOCHONDRIAL BIOGENESIS 6 0.03490 -0.499 0.597
REACTOME FATTY ACID METABOLISM 11 0.04010 -0.360 0.649
REACTOME MET ACTIVATES PTK2 SIGNALING 8 0.04050 -0.420 0.649
REACTOME EPHB MEDIATED FORWARD SIGNALING 12 0.04340 -0.339 0.659
REACTOME RHOBTB2 GTPASE CYCLE 7 0.04370 -0.442 0.659
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS 9 0.04520 -0.387 0.663
REACTOME SMOOTH MUSCLE CONTRACTION 12 0.05700 -0.320 0.812
REACTOME RHO GTPASE CYCLE 38 0.06830 -0.175 0.883
REACTOME ECM PROTEOGLYCANS 23 0.06850 -0.222 0.883
REACTOME RHOH GTPASE CYCLE 8 0.06860 -0.374 0.883
REACTOME METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 7 0.07160 0.395 0.883
REACTOME RHO GTPASES ACTIVATE PAKS 7 0.07370 -0.392 0.883
REACTOME INTERACTION BETWEEN L1 AND ANKYRINS 5 0.07670 0.459 0.883
REACTOME SIGNALING BY VEGF 13 0.07810 -0.284 0.883
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS 5 0.07910 0.455 0.883
REACTOME LECTIN PATHWAY OF COMPLEMENT ACTIVATION 8 0.08150 0.357 0.883
REACTOME ORGANELLE BIOGENESIS AND MAINTENANCE 24 0.08350 -0.207 0.883
REACTOME ASPARAGINE N LINKED GLYCOSYLATION 41 0.08370 0.160 0.883
REACTOME HSF1 ACTIVATION 7 0.08470 -0.378 0.883
REACTOME RNA POLYMERASE II TRANSCRIPTION 50 0.08640 -0.144 0.883
REACTOME ANTIGEN PROCESSING UB ATP INDEPENDENT PROTEASOMAL DEGRADATION 8 0.08660 -0.352 0.883


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
REACTOME METABOLISM OF LIPIDS 30 0.00174 -0.335000 0.423
REACTOME PEPTIDE HORMONE METABOLISM 15 0.00405 0.432000 0.423
REACTOME FORMATION OF THE CORNIFIED ENVELOPE 28 0.00411 0.318000 0.423
REACTOME KERATINIZATION 28 0.00411 0.318000 0.423
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN 10 0.00444 -0.522000 0.423
REACTOME SYNDECAN INTERACTIONS 10 0.00535 -0.511000 0.423
REACTOME DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 9 0.00594 -0.532000 0.423
REACTOME NON INTEGRIN MEMBRANE ECM INTERACTIONS 19 0.00660 -0.363000 0.423
REACTOME NEUTROPHIL DEGRANULATION 152 0.00742 0.137000 0.423
REACTOME MITOCHONDRIAL PROTEIN DEGRADATION 6 0.00914 -0.616000 0.450
REACTOME EPHA MEDIATED GROWTH CONE COLLAPSE 7 0.01040 -0.561000 0.450
REACTOME INNATE IMMUNE SYSTEM 266 0.01070 0.108000 0.450
REACTOME ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 5 0.01230 0.648000 0.450
REACTOME ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 5 0.01230 0.648000 0.450
REACTOME RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 5 0.01780 -0.613000 0.586
REACTOME DISEASES OF CARBOHYDRATE METABOLISM 6 0.01900 0.555000 0.586
REACTOME CELLULAR RESPONSES TO STIMULI 87 0.01940 -0.152000 0.586
REACTOME RHOBTB GTPASE CYCLE 8 0.02170 -0.471000 0.597
REACTOME COMPLEMENT CASCADE 80 0.02250 0.154000 0.597
REACTOME SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 70 0.02440 -0.162000 0.597
REACTOME MUSCLE CONTRACTION 16 0.02580 -0.325000 0.597
REACTOME EPH EPHRIN SIGNALING 20 0.02600 -0.291000 0.597
REACTOME SCAVENGING BY CLASS B RECEPTORS 7 0.02870 -0.479000 0.597
REACTOME LYSOSOME VESICLE BIOGENESIS 6 0.02950 0.515000 0.597
REACTOME FOLDING OF ACTIN BY CCT TRIC 6 0.02970 -0.514000 0.597
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 6 0.03240 -0.506000 0.597
REACTOME SENSORY PROCESSING OF SOUND 5 0.03250 -0.554000 0.597
REACTOME PHOSPHOLIPID METABOLISM 5 0.03350 -0.551000 0.597
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 10 0.03470 -0.388000 0.597
REACTOME MITOCHONDRIAL BIOGENESIS 6 0.03490 -0.499000 0.597
REACTOME FATTY ACID METABOLISM 11 0.04010 -0.360000 0.649
REACTOME MET ACTIVATES PTK2 SIGNALING 8 0.04050 -0.420000 0.649
REACTOME EPHB MEDIATED FORWARD SIGNALING 12 0.04340 -0.339000 0.659
REACTOME RHOBTB2 GTPASE CYCLE 7 0.04370 -0.442000 0.659
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS 9 0.04520 -0.387000 0.663
REACTOME SMOOTH MUSCLE CONTRACTION 12 0.05700 -0.320000 0.812
REACTOME RHO GTPASE CYCLE 38 0.06830 -0.175000 0.883
REACTOME ECM PROTEOGLYCANS 23 0.06850 -0.222000 0.883
REACTOME RHOH GTPASE CYCLE 8 0.06860 -0.374000 0.883
REACTOME METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 7 0.07160 0.395000 0.883
REACTOME RHO GTPASES ACTIVATE PAKS 7 0.07370 -0.392000 0.883
REACTOME INTERACTION BETWEEN L1 AND ANKYRINS 5 0.07670 0.459000 0.883
REACTOME SIGNALING BY VEGF 13 0.07810 -0.284000 0.883
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS 5 0.07910 0.455000 0.883
REACTOME LECTIN PATHWAY OF COMPLEMENT ACTIVATION 8 0.08150 0.357000 0.883
REACTOME ORGANELLE BIOGENESIS AND MAINTENANCE 24 0.08350 -0.207000 0.883
REACTOME ASPARAGINE N LINKED GLYCOSYLATION 41 0.08370 0.160000 0.883
REACTOME HSF1 ACTIVATION 7 0.08470 -0.378000 0.883
REACTOME RNA POLYMERASE II TRANSCRIPTION 50 0.08640 -0.144000 0.883
REACTOME ANTIGEN PROCESSING UB ATP INDEPENDENT PROTEASOMAL DEGRADATION 8 0.08660 -0.352000 0.883
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE 32 0.08900 0.177000 0.883
REACTOME CELL JUNCTION ORGANIZATION 46 0.09100 -0.148000 0.883
REACTOME SIGNALING BY NOTCH3 5 0.09120 -0.438000 0.883
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 65 0.09680 -0.123000 0.920
REACTOME METABOLISM OF STEROIDS 5 0.09970 -0.426000 0.925
REACTOME GP1B IX V ACTIVATION SIGNALLING 8 0.10200 -0.336000 0.925
REACTOME SIGNALING BY NOTCH4 16 0.10300 -0.238000 0.925
REACTOME GLUTATHIONE CONJUGATION 5 0.10800 -0.417000 0.953
REACTOME MYD88 INDEPENDENT TLR4 CASCADE 6 0.11500 0.373000 0.967
REACTOME TOLL LIKE RECEPTOR 9 TLR9 CASCADE 6 0.11500 0.373000 0.967
REACTOME TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 6 0.11700 0.371000 0.967
REACTOME O LINKED GLYCOSYLATION 9 0.11700 -0.303000 0.967
REACTOME METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS 5 0.11900 -0.404000 0.967
REACTOME COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 11 0.12700 -0.267000 0.994
REACTOME FORMATION OF THE DYSTROPHIN GLYCOPROTEIN COMPLEX DGC 7 0.12900 -0.333000 0.994
REACTOME GLYCOSAMINOGLYCAN METABOLISM 14 0.12900 0.236000 0.994
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX1 18 0.13100 -0.208000 0.994
REACTOME INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 22 0.13600 0.186000 0.994
REACTOME INFECTIOUS DISEASE 161 0.13700 -0.074700 0.994
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 103 0.14200 -0.088800 0.994
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 9 0.14300 -0.283000 0.994
REACTOME LDL REMODELING 5 0.14400 -0.379000 0.994
REACTOME PLASMA LIPOPROTEIN REMODELING 17 0.14700 -0.205000 0.994
REACTOME DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN 6 0.14900 -0.341000 0.994
REACTOME PLATELET HOMEOSTASIS 6 0.15700 -0.335000 0.994
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 10 0.15900 -0.259000 0.994
REACTOME SENSORY PERCEPTION 20 0.15900 -0.184000 0.994
REACTOME CELLULAR RESPONSES TO MECHANICAL STIMULI 18 0.16100 -0.193000 0.994
REACTOME SEMAPHORIN INTERACTIONS 16 0.16300 -0.204000 0.994
REACTOME ATTENUATION PHASE 5 0.16300 -0.362000 0.994
REACTOME HSF1 DEPENDENT TRANSACTIVATION 5 0.16300 -0.362000 0.994
REACTOME UPTAKE AND ACTIONS OF BACTERIAL TOXINS 6 0.17000 -0.325000 0.994
REACTOME EPH EPHRIN MEDIATED REPULSION OF CELLS 7 0.17700 -0.296000 0.994
REACTOME C TYPE LECTIN RECEPTORS CLRS 17 0.18000 -0.190000 0.994
REACTOME ARACHIDONATE METABOLISM 9 0.18300 -0.258000 0.994
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 10 0.18900 0.242000 0.994
REACTOME DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 51 0.19600 -0.108000 0.994
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 9 0.19600 0.250000 0.994
REACTOME CELL CELL COMMUNICATION 51 0.19900 -0.107000 0.994
REACTOME ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER COLLAGEN 5 0.20100 -0.331000 0.994
REACTOME MAP2K AND MAPK ACTIVATION 16 0.20200 0.186000 0.994
REACTOME MATURATION OF SARS COV 2 SPIKE PROTEIN 5 0.20400 0.329000 0.994
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 7 0.20700 -0.277000 0.994
REACTOME KERATAN SULFATE BIOSYNTHESIS 6 0.21500 0.294000 0.994
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 28 0.21600 0.137000 0.994
REACTOME TURBULENT OSCILLATORY DISTURBED FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS 7 0.21800 -0.270000 0.994
REACTOME AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT 13 0.22200 -0.197000 0.994
REACTOME ION CHANNEL TRANSPORT 5 0.22200 -0.317000 0.994
REACTOME IRE1ALPHA ACTIVATES CHAPERONES 6 0.22800 -0.285000 0.994
REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 6 0.22900 0.285000 0.994
REACTOME UNFOLDED PROTEIN RESPONSE UPR 8 0.23300 -0.245000 0.994
REACTOME RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY 9 0.23600 -0.230000 0.994
REACTOME NERVOUS SYSTEM DEVELOPMENT 72 0.23700 -0.083900 0.994
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 36 0.23700 -0.116000 0.994
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 8 0.24300 -0.240000 0.994
REACTOME DISEASES OF GLYCOSYLATION 16 0.25400 -0.166000 0.994
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 82 0.25500 -0.076200 0.994
REACTOME INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 9 0.25500 0.220000 0.994
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 7 0.25700 0.249000 0.994
REACTOME TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 5 0.25800 0.293000 0.994
REACTOME BASIGIN INTERACTIONS 5 0.26000 -0.292000 0.994
REACTOME DENGUE VIRUS GENOME TRANSLATION AND REPLICATION 12 0.26100 -0.189000 0.994
REACTOME SIGNALING BY ROBO RECEPTORS 17 0.26200 -0.159000 0.994
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 12 0.26300 0.188000 0.994
REACTOME NUCLEAR EVENTS MEDIATED BY NFE2L2 21 0.26400 -0.143000 0.994
REACTOME FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE 5 0.26500 0.289000 0.994
REACTOME VIRAL INFECTION PATHWAYS 119 0.26800 -0.063000 0.994
REACTOME COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 8 0.26800 -0.227000 0.994
REACTOME ACTIVATION OF MATRIX METALLOPROTEINASES 9 0.27000 0.214000 0.994
REACTOME RAB GERANYLGERANYLATION 9 0.27200 -0.213000 0.994
REACTOME HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1 CDH5 KDR IN ENDOTHELIAL CELLS 12 0.27700 -0.183000 0.994
REACTOME DNA REPAIR 5 0.28800 -0.276000 0.994
REACTOME LAMININ INTERACTIONS 10 0.29200 -0.194000 0.994
REACTOME HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR IN THE PRESENCE OF LIGAND 13 0.29400 -0.169000 0.994
REACTOME CALNEXIN CALRETICULIN CYCLE 7 0.29700 0.229000 0.994
REACTOME FORMATION OF PARAXIAL MESODERM 11 0.29800 -0.182000 0.994
REACTOME SOMITOGENESIS 11 0.29800 -0.182000 0.994
REACTOME NUCLEOTIDE SALVAGE 5 0.29900 -0.269000 0.994
REACTOME SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 17 0.30000 0.147000 0.994
REACTOME PROTEIN FOLDING 15 0.30400 -0.155000 0.994
REACTOME MATURATION OF DENV PROTEINS 8 0.30600 -0.210000 0.994
REACTOME TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 11 0.30900 0.178000 0.994
REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX 28 0.31800 0.111000 0.994
REACTOME DRUG ADME 11 0.32300 -0.173000 0.994
REACTOME TRANSCRIPTIONAL AND POST TRANSLATIONAL REGULATION OF MITF M EXPRESSION AND ACTIVITY 8 0.32400 0.203000 0.994
REACTOME DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 6 0.32400 0.233000 0.994
REACTOME CELLULAR RESPONSE TO HEAT STRESS 12 0.32500 -0.165000 0.994
REACTOME RHO GTPASE EFFECTORS 40 0.32700 -0.091600 0.994
REACTOME GPER1 SIGNALING 7 0.32700 -0.215000 0.994
REACTOME CHYLOMICRON ASSEMBLY 8 0.32800 -0.201000 0.994
REACTOME CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 6 0.32900 -0.231000 0.994
REACTOME PI3K AKT SIGNALING IN CANCER 6 0.32900 -0.231000 0.994
REACTOME DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM 22 0.33100 0.121000 0.994
REACTOME LATE SARS COV 2 INFECTION EVENTS 7 0.33500 0.212000 0.994
REACTOME LATE ENDOSOMAL MICROAUTOPHAGY 5 0.33600 0.249000 0.994
REACTOME TRANSCRIPTIONAL REGULATION BY TP53 16 0.34000 -0.139000 0.994
REACTOME COMMON PATHWAY OF FIBRIN CLOT FORMATION 17 0.34200 0.134000 0.994
REACTOME ADHERENS JUNCTIONS INTERACTIONS 34 0.34300 -0.095900 0.994
REACTOME STRIATED MUSCLE CONTRACTION 5 0.34600 -0.244000 0.994
REACTOME MET PROMOTES CELL MOTILITY 10 0.35000 -0.172000 0.994
REACTOME REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE 5 0.35000 0.242000 0.994
REACTOME METABOLISM OF CARBOHYDRATES AND CARBOHYDRATE DERIVATIVES 42 0.35400 0.084700 0.994
REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS 7 0.35400 0.203000 0.994
REACTOME REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA CARBOXYLATED PROTEINS 7 0.35400 0.203000 0.994
REACTOME INITIAL TRIGGERING OF COMPLEMENT 56 0.35400 0.073900 0.994
REACTOME TRANSLATION 17 0.35700 -0.130000 0.994
REACTOME ESR MEDIATED SIGNALING 13 0.35800 -0.149000 0.994
REACTOME COLLAGEN DEGRADATION 10 0.35900 0.168000 0.994
REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 11 0.36700 0.158000 0.994
REACTOME KEAP1 NFE2L2 PATHWAY 23 0.36900 -0.110000 0.994
REACTOME DENGUE VIRUS INFECTION 33 0.37200 -0.091500 0.994
REACTOME INTERLEUKIN 12 FAMILY SIGNALING 16 0.37400 -0.130000 0.994
REACTOME REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 13 0.37800 -0.142000 0.994
REACTOME DEVELOPMENTAL CELL LINEAGES 37 0.37900 0.085300 0.994
REACTOME HEMOSTASIS 184 0.38100 -0.041800 0.994
REACTOME RHOA GTPASE CYCLE 12 0.38100 -0.147000 0.994
REACTOME EXTRA NUCLEAR ESTROGEN SIGNALING 11 0.38200 -0.153000 0.994
REACTOME DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS 10 0.38400 -0.160000 0.994
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 14 0.38400 -0.136000 0.994
REACTOME ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 10 0.38400 0.160000 0.994
REACTOME FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 53 0.38900 -0.070400 0.994
REACTOME RAC3 GTPASE CYCLE 8 0.39200 -0.176000 0.994
REACTOME REGULATION OF CDH1 FUNCTION 20 0.39300 -0.112000 0.994
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 9 0.39300 0.165000 0.994
REACTOME CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 12 0.39400 -0.143000 0.994
REACTOME REGULATION OF T CELL ACTIVATION BY CD28 FAMILY 17 0.39500 -0.120000 0.994
REACTOME ABC TRANSPORTER DISORDERS 13 0.39600 -0.137000 0.994
REACTOME PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 7 0.40000 -0.185000 0.994
REACTOME GASTRULATION 14 0.40300 -0.130000 0.994
REACTOME HCMV EARLY EVENTS 8 0.40500 -0.171000 0.994
REACTOME HCMV INFECTION 8 0.40500 -0.171000 0.994
REACTOME HOST INTERACTIONS OF HIV FACTORS 16 0.40600 -0.121000 0.994
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX3 15 0.41100 -0.124000 0.994
REACTOME SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 5 0.41300 0.212000 0.994
REACTOME PARASITE INFECTION 50 0.41400 -0.068700 0.994
REACTOME PHASE II CONJUGATION OF COMPOUNDS 7 0.41600 -0.178000 0.994
REACTOME TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 18 0.41900 -0.111000 0.994
REACTOME SIGNALING BY WNT 18 0.42100 -0.111000 0.994
REACTOME ONCOGENIC MAPK SIGNALING 18 0.42400 0.110000 0.994
REACTOME SIGNALING BY BRAF AND RAF1 FUSIONS 18 0.42400 0.110000 0.994
REACTOME DISSOLUTION OF FIBRIN CLOT 6 0.42900 -0.187000 0.994
REACTOME MITF M REGULATED MELANOCYTE DEVELOPMENT 15 0.43000 0.119000 0.994
REACTOME PRE NOTCH PROCESSING IN GOLGI 6 0.43500 -0.185000 0.994
REACTOME CO INHIBITION BY PD 1 13 0.43500 -0.126000 0.994
REACTOME REGULATION OF PD L1 CD274 EXPRESSION 13 0.43500 -0.126000 0.994
REACTOME REGULATION OF PD L1 CD274 POST TRANSLATIONAL MODIFICATION 13 0.43500 -0.126000 0.994
REACTOME ADAPTIVE IMMUNE SYSTEM 117 0.43900 -0.044300 0.994
REACTOME INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 22 0.44200 -0.095900 0.994
REACTOME CREATION OF C4 AND C2 ACTIVATORS 49 0.44300 0.065200 0.994
REACTOME KERATAN SULFATE KERATIN METABOLISM 7 0.44300 0.168000 0.994
REACTOME CILIUM ASSEMBLY 18 0.44400 -0.105000 0.994
REACTOME RHO GTPASES ACTIVATE CIT 5 0.44400 -0.198000 0.994
REACTOME HIV INFECTION 17 0.44500 -0.108000 0.994
REACTOME DENGUE VIRUS HOST INTERACTIONS 18 0.44600 -0.105000 0.994
REACTOME SCAVENGING BY CLASS A RECEPTORS 11 0.44700 -0.133000 0.994
REACTOME KINESINS 6 0.44700 0.180000 0.994
REACTOME SIGNALING BY EGFR 5 0.44900 -0.196000 0.994
REACTOME METABOLISM OF RNA 19 0.45300 -0.101000 0.994
REACTOME ENDOSOMAL VACUOLAR PATHWAY 5 0.45300 -0.195000 0.994
REACTOME G PROTEIN MEDIATED EVENTS 5 0.45400 0.194000 0.994
REACTOME LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 5 0.46000 0.192000 0.994
REACTOME SIGNALING BY MET 13 0.46200 -0.119000 0.994
REACTOME METABOLISM OF VITAMINS AND COFACTORS 27 0.46700 -0.082200 0.994
REACTOME FCERI MEDIATED MAPK ACTIVATION 37 0.46700 0.070600 0.994
REACTOME LEISHMANIA INFECTION 62 0.46700 -0.055300 0.994
REACTOME SCAVENGING OF HEME FROM PLASMA 46 0.46900 0.063300 0.994
REACTOME SIGNALING BY FGFR 5 0.47200 0.187000 0.994
REACTOME SIGNALING BY FGFR2 5 0.47200 0.187000 0.994
REACTOME FLT3 SIGNALING 5 0.47300 0.186000 0.994
REACTOME CLEC7A DECTIN 1 SIGNALING 15 0.47300 -0.108000 0.994
REACTOME SIGNALING BY HEDGEHOG 21 0.47900 0.090400 0.994
REACTOME UCH PROTEINASES 13 0.48100 -0.114000 0.994
REACTOME METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 10 0.49200 -0.126000 0.994
REACTOME RAB REGULATION OF TRAFFICKING 12 0.49700 -0.114000 0.994
REACTOME SIGNALING BY RECEPTOR TYROSINE KINASES 49 0.49700 -0.057600 0.994
REACTOME DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES 12 0.49900 -0.114000 0.994
REACTOME DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN 16 0.50200 0.098000 0.994
REACTOME DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A 5 0.50300 0.174000 0.994
REACTOME SPOP MEDIATED PROTEASOMAL DEGRADATION OF PD L1 CD274 12 0.50300 -0.112000 0.994
REACTOME SIGNALING BY NOTCH 24 0.50600 -0.079500 0.994
REACTOME REGULATION OF EXPRESSION OF SLITS AND ROBOS 12 0.50600 -0.112000 0.994
REACTOME HDL REMODELING 8 0.51200 -0.135000 0.994
REACTOME MAPK1 MAPK3 SIGNALING 38 0.51200 0.062800 0.994
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 12 0.51700 -0.109000 0.994
REACTOME PLATELET AGGREGATION PLUG FORMATION 18 0.52100 -0.088400 0.994
REACTOME ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 47 0.52400 -0.055200 0.994
REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK 9 0.52700 -0.123000 0.994
REACTOME COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 8 0.52700 0.130000 0.994
REACTOME DEFECTIVE F9 ACTIVATION 6 0.53000 -0.149000 0.994
REACTOME G ALPHA Q SIGNALLING EVENTS 14 0.53000 0.097800 0.994
REACTOME UB SPECIFIC PROCESSING PROTEASES 13 0.53500 0.100000 0.994
REACTOME MITOTIC G1 PHASE AND G1 S TRANSITION 12 0.53900 -0.103000 0.994
REACTOME ELASTIC FIBRE FORMATION 10 0.53900 -0.113000 0.994
REACTOME MOLECULES ASSOCIATED WITH ELASTIC FIBRES 10 0.53900 -0.113000 0.994
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 14 0.54000 -0.095500 0.994
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 77 0.54400 -0.041800 0.994
REACTOME INFLUENZA INFECTION 8 0.54700 -0.124000 0.994
REACTOME SIGNALING BY GPCR 32 0.54900 -0.062400 0.994
REACTOME CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 10 0.55000 0.110000 0.994
REACTOME METABOLISM OF POLYAMINES 10 0.55000 -0.110000 0.994
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC 10 0.55000 -0.110000 0.994
REACTOME FCGR ACTIVATION 39 0.55200 -0.056400 0.994
REACTOME TRANSPORT OF SMALL MOLECULES 63 0.55200 -0.044900 0.994
REACTOME THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 18 0.55400 -0.081400 0.994
REACTOME PYRUVATE METABOLISM 6 0.55700 0.139000 0.994
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 9 0.55900 0.113000 0.994
REACTOME DISORDERS OF TRANSMEMBRANE TRANSPORTERS 18 0.56000 -0.080300 0.994
REACTOME GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 14 0.56000 -0.090700 0.994
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 20 0.56600 -0.075100 0.994
REACTOME ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 6 0.56600 -0.136000 0.994
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 6 0.56600 -0.136000 0.994
REACTOME METABOLISM OF FAT SOLUBLE VITAMINS 13 0.56600 -0.092600 0.994
REACTOME AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 14 0.56700 -0.089200 0.994
REACTOME ANTIMICROBIAL PEPTIDES 14 0.56800 -0.088900 0.994
REACTOME NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 7 0.57200 0.124000 0.994
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 16 0.57300 -0.082200 0.994
REACTOME DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS 7 0.57500 0.123000 0.994
REACTOME DISEASES OF PROGRAMMED CELL DEATH 7 0.57500 0.123000 0.994
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 10 0.57600 0.103000 0.994
REACTOME DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS 6 0.58000 0.131000 0.994
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION 5 0.58100 -0.143000 0.994
REACTOME RHO GTPASES ACTIVATE ROCKS 7 0.58300 -0.121000 0.994
REACTOME INFECTION WITH ENTEROBACTERIA 9 0.58500 0.106000 0.994
REACTOME DETOXIFICATION OF REACTIVE OXYGEN SPECIES 15 0.58800 -0.081500 0.994
REACTOME ER TO GOLGI ANTEROGRADE TRANSPORT 23 0.58900 0.066000 0.994
REACTOME CELLULAR RESPONSE TO CHEMICAL STRESS 38 0.58900 -0.051700 0.994
REACTOME RESOLUTION OF SISTER CHROMATID COHESION 7 0.59000 0.118000 0.994
REACTOME INTERFERON GAMMA SIGNALING 9 0.59000 0.104000 0.994
REACTOME INTRACELLULAR SIGNALING BY SECOND MESSENGERS 22 0.59000 -0.067200 0.994
REACTOME FCGR3A MEDIATED IL10 SYNTHESIS 41 0.59200 -0.049500 0.994
REACTOME MAPK FAMILY SIGNALING CASCADES 40 0.59200 0.050100 0.994
REACTOME OPIOID SIGNALLING 8 0.59200 0.110000 0.994
REACTOME DAP12 INTERACTIONS 6 0.59500 -0.126000 0.994
REACTOME TERMINAL PATHWAY OF COMPLEMENT 8 0.59900 0.108000 0.994
REACTOME HEDGEHOG OFF STATE 16 0.60100 0.076300 0.994
REACTOME FOXO MEDIATED TRANSCRIPTION 6 0.60400 0.123000 0.994
REACTOME CLATHRIN MEDIATED ENDOCYTOSIS 19 0.60600 -0.069000 0.994
REACTOME INTERLEUKIN 12 SIGNALING 15 0.61000 -0.076700 0.994
REACTOME SIGNAL AMPLIFICATION 5 0.61300 -0.131000 0.994
REACTOME MITOTIC G2 G2 M PHASES 24 0.61900 -0.059500 0.994
REACTOME CHYLOMICRON REMODELING 9 0.62100 -0.095700 0.994
REACTOME REGULATION OF HOMOTYPIC CELL CELL ADHESION 26 0.62200 -0.056800 0.994
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 66 0.62600 -0.036000 0.994
REACTOME SARS COV 1 HOST INTERACTIONS 11 0.62900 -0.084800 0.994
REACTOME RHO GTPASES ACTIVATE PKNS 10 0.63200 -0.087900 0.994
REACTOME SIGNALING BY CSF1 M CSF IN MYELOID CELLS 5 0.63600 0.123000 0.994
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 9 0.63700 -0.091500 0.994
REACTOME POTENTIAL THERAPEUTICS FOR SARS 43 0.63700 -0.042600 0.994
REACTOME NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 13 0.63700 0.076200 0.994
REACTOME ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 10 0.63800 -0.086600 0.994
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 51 0.64400 -0.038500 0.994
REACTOME MITOTIC PROMETAPHASE 12 0.64800 0.076800 0.994
REACTOME HH MUTANTS ABROGATE LIGAND SECRETION 14 0.65100 -0.070500 0.994
REACTOME RHO GTPASES ACTIVATE WASPS AND WAVES 10 0.65200 -0.083000 0.994
REACTOME MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE UPRMT 5 0.65400 0.116000 0.994
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 27 0.65600 -0.050400 0.994
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 16 0.66200 -0.063800 0.994
REACTOME BACTERIAL INFECTION PATHWAYS 26 0.66500 0.049900 0.994
REACTOME MAPK6 MAPK4 SIGNALING 13 0.66900 -0.069200 0.994
REACTOME TCR SIGNALING 16 0.67500 0.061200 0.994
REACTOME AMPK INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD L1 CD274 12 0.68900 -0.067300 0.994
REACTOME RIBOSOME ASSOCIATED QUALITY CONTROL 12 0.68900 -0.067300 0.994
REACTOME RIBOSOME QUALITY CONTROL RQC COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE 12 0.68900 -0.067300 0.994
REACTOME DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS 8 0.68900 0.082000 0.994
REACTOME REGULATION OF TLR BY ENDOGENOUS LIGAND 8 0.69000 -0.081800 0.994
REACTOME REGULATION OF INSULIN SECRETION 6 0.69100 0.094300 0.994
REACTOME INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 19 0.69300 0.053000 0.994
REACTOME TP53 REGULATES METABOLIC GENES 12 0.69300 -0.066300 0.994
REACTOME ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 5 0.69500 0.102000 0.994
REACTOME AMYLOID FIBER FORMATION 18 0.69600 0.053800 0.994
REACTOME BIOLOGICAL OXIDATIONS 19 0.69600 -0.052400 0.994
REACTOME METABOLISM OF NUCLEOTIDES 9 0.69700 -0.075400 0.994
REACTOME HEDGEHOG LIGAND BIOGENESIS 15 0.70100 -0.057800 0.994
REACTOME VISUAL PHOTOTRANSDUCTION 15 0.70400 -0.057200 0.994
REACTOME BETA CATENIN INDEPENDENT WNT SIGNALING 16 0.70500 -0.055200 0.994
REACTOME GAP JUNCTION TRAFFICKING AND REGULATION 8 0.71300 -0.075600 0.994
REACTOME INTEGRIN SIGNALING 13 0.71700 0.058600 0.994
REACTOME COPI MEDIATED ANTEROGRADE TRANSPORT 16 0.72000 0.052400 0.994
REACTOME SARS COV 1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS 6 0.72100 0.084600 0.994
REACTOME RHOC GTPASE CYCLE 9 0.72100 0.069100 0.994
REACTOME PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 24 0.72300 -0.042300 0.994
REACTOME RAB GEFS EXCHANGE GTP FOR GDP ON RABS 11 0.73400 -0.059600 0.994
REACTOME PROTEIN LOCALIZATION 9 0.73700 -0.064900 0.994
REACTOME REGULATED NECROSIS 5 0.74800 0.083400 0.994
REACTOME DEUBIQUITINATION 17 0.75100 -0.044900 0.994
REACTOME SARS COV 2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES 11 0.75300 -0.055300 0.994
REACTOME MITF M DEPENDENT GENE EXPRESSION 8 0.75500 0.064200 0.994
REACTOME NR1H2 AND NR1H3 MEDIATED SIGNALING 8 0.75500 0.064200 0.994
REACTOME PCP CE PATHWAY 13 0.75600 -0.050200 0.994
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 13 0.75900 0.049500 0.994
REACTOME NEGATIVE REGULATION OF NOTCH4 SIGNALING 12 0.76000 -0.051400 0.994
REACTOME TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 12 0.76000 -0.051400 0.994
REACTOME G ALPHA S SIGNALLING EVENTS 8 0.76000 -0.062800 0.994
REACTOME PROTEASOME ASSEMBLY 12 0.76100 -0.051000 0.994
REACTOME DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B 8 0.76200 -0.062200 0.994
REACTOME INTEGRATION OF ENERGY METABOLISM 10 0.76200 -0.055700 0.994
REACTOME SIGNALING BY ERBB4 6 0.76300 -0.071300 0.994
REACTOME TOLL LIKE RECEPTOR CASCADES 17 0.76500 0.042400 0.994
REACTOME GAMMA CARBOXYLATION HYPUSINYLATION HYDROXYLATION AND ARYLSULFATASE ACTIVATION 9 0.76500 0.058000 0.994
REACTOME FCERI MEDIATED CA 2 MOBILIZATION 37 0.76500 0.029000 0.994
REACTOME RND1 GTPASE CYCLE 5 0.76700 -0.076800 0.994
REACTOME SARS COV INFECTIONS 70 0.76900 -0.021100 0.994
REACTOME GLUCONEOGENESIS 9 0.77100 0.056500 0.994
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 6 0.77100 0.069000 0.994
REACTOME DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS 8 0.77200 0.059400 0.994
REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 61 0.77500 0.021900 0.994
REACTOME ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS 5 0.77600 -0.073600 0.994
REACTOME RAC1 GTPASE CYCLE 8 0.77700 -0.058000 0.994
REACTOME RESPONSE OF MTB TO PHAGOCYTOSIS 6 0.77800 0.066800 0.994
REACTOME SIGNALING BY INTERLEUKINS 60 0.77900 -0.021700 0.994
REACTOME SIGNALING BY ALK IN CANCER 14 0.77900 -0.043700 0.994
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 16 0.78000 0.040800 0.994
REACTOME M PHASE 27 0.78100 0.031400 0.994
REACTOME NUCLEAR ENVELOPE NE REASSEMBLY 6 0.78500 0.064600 0.994
REACTOME SIGNALING BY ERBB2 7 0.78500 -0.059700 0.994
REACTOME ACTIVATION OF APC C AND APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 11 0.78700 -0.047300 0.994
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 11 0.78700 -0.047300 0.994
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 11 0.78700 -0.047300 0.994
REACTOME APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 11 0.78700 -0.047300 0.994
REACTOME ASYMMETRIC LOCALIZATION OF PCP PROTEINS 11 0.78700 -0.047300 0.994
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 11 0.78700 -0.047300 0.994
REACTOME CELLULAR RESPONSE TO HYPOXIA 11 0.78700 -0.047300 0.994
REACTOME CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 11 0.78700 -0.047300 0.994
REACTOME DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 11 0.78700 -0.047300 0.994
REACTOME DEGRADATION OF AXIN 11 0.78700 -0.047300 0.994
REACTOME DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 11 0.78700 -0.047300 0.994
REACTOME DEGRADATION OF CRY AND PER PROTEINS 11 0.78700 -0.047300 0.994
REACTOME DEGRADATION OF DVL 11 0.78700 -0.047300 0.994
REACTOME DEGRADATION OF GLI1 BY THE PROTEASOME 11 0.78700 -0.047300 0.994
REACTOME DNA REPLICATION 11 0.78700 -0.047300 0.994
REACTOME DNA REPLICATION PRE INITIATION 11 0.78700 -0.047300 0.994
REACTOME FBXL7 DOWN REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS 11 0.78700 -0.047300 0.994
REACTOME G1 S DNA DAMAGE CHECKPOINTS 11 0.78700 -0.047300 0.994
REACTOME GSK3B MEDIATED PROTEASOMAL DEGRADATION OF PD L1 CD274 11 0.78700 -0.047300 0.994
REACTOME ORC1 REMOVAL FROM CHROMATIN 11 0.78700 -0.047300 0.994
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE 11 0.78700 -0.047300 0.994
REACTOME REGULATION OF APOPTOSIS 11 0.78700 -0.047300 0.994
REACTOME REGULATION OF PTEN STABILITY AND ACTIVITY 11 0.78700 -0.047300 0.994
REACTOME REGULATION OF RAS BY GAPS 11 0.78700 -0.047300 0.994
REACTOME REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 11 0.78700 -0.047300 0.994
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 11 0.78700 -0.047300 0.994
REACTOME S PHASE 11 0.78700 -0.047300 0.994
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 11 0.78700 -0.047300 0.994
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21 11 0.78700 -0.047300 0.994
REACTOME STABILIZATION OF P53 11 0.78700 -0.047300 0.994
REACTOME SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 11 0.78700 -0.047300 0.994
REACTOME SYNTHESIS OF DNA 11 0.78700 -0.047300 0.994
REACTOME TNFR2 NON CANONICAL NF KB PATHWAY 11 0.78700 -0.047300 0.994
REACTOME UBIQUITIN DEPENDENT DEGRADATION OF CYCLIN D 11 0.78700 -0.047300 0.994
REACTOME UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 11 0.78700 -0.047300 0.994
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G 11 0.78700 -0.047300 0.994
REACTOME SLC TRANSPORTER DISORDERS 5 0.79100 0.068700 0.994
REACTOME G ALPHA I SIGNALLING EVENTS 19 0.79500 0.034800 0.994
REACTOME INTERFERON SIGNALING 20 0.79600 0.033800 0.994
REACTOME NEDDYLATION 14 0.79600 -0.040300 0.994
REACTOME RAC2 GTPASE CYCLE 6 0.79800 -0.060500 0.994
REACTOME GLYCOGEN METABOLISM 6 0.79800 0.060500 0.994
REACTOME SIGNALING BY SCF KIT 5 0.80000 -0.065600 0.994
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX2 15 0.80300 -0.037600 0.994
REACTOME PLASMA LIPOPROTEIN CLEARANCE 8 0.80400 0.051100 0.994
REACTOME RHO GTPASES ACTIVATE IQGAPS 9 0.80500 0.047800 0.994
REACTOME CELL CYCLE MITOTIC 30 0.80700 -0.026200 0.994
REACTOME PTEN REGULATION 12 0.80800 0.040900 0.994
REACTOME NEURONAL SYSTEM 23 0.81500 -0.028600 0.994
REACTOME REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 10 0.81700 0.042500 0.994
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 12 0.81900 -0.038500 0.994
REACTOME DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS 13 0.81900 0.036900 0.994
REACTOME ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 6 0.82100 -0.053500 0.994
REACTOME ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 10 0.82500 0.040700 0.994
REACTOME DOWNSTREAM TCR SIGNALING 12 0.83000 -0.036100 0.994
REACTOME INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 5 0.83100 0.055400 0.994
REACTOME MITOTIC METAPHASE AND ANAPHASE 19 0.83100 0.028600 0.994
REACTOME SARS COV 2 HOST INTERACTIONS 16 0.83300 -0.030800 0.994
REACTOME CARGO CONCENTRATION IN THE ER 6 0.84100 0.047500 0.994
REACTOME RHOJ GTPASE CYCLE 6 0.84100 0.047500 0.994
REACTOME RHOQ GTPASE CYCLE 6 0.84100 0.047500 0.994
REACTOME RECYCLING PATHWAY OF L1 11 0.84200 0.034900 0.994
REACTOME RHOB GTPASE CYCLE 10 0.84800 -0.035100 0.994
REACTOME DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS 15 0.84900 0.028700 0.994
REACTOME PLASMA LIPOPROTEIN ASSEMBLY 12 0.85000 -0.031800 0.994
REACTOME DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND 10 0.85100 0.034500 0.994
REACTOME SELECTIVE AUTOPHAGY 14 0.85200 0.029100 0.994
REACTOME SIGNALING BY PDGF 8 0.85600 0.037400 0.994
REACTOME G2 M CHECKPOINTS 16 0.86200 -0.025300 0.994
REACTOME CHAPERONE MEDIATED AUTOPHAGY 9 0.86300 0.033400 0.994
REACTOME AGGREPHAGY 11 0.86400 0.030000 0.994
REACTOME SARS COV 2 INFECTION 25 0.86500 0.020000 0.994
REACTOME CIRCADIAN CLOCK 14 0.86600 -0.026300 0.994
REACTOME ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 37 0.86700 0.016300 0.994
REACTOME FCERI MEDIATED NF KB ACTIVATION 47 0.86900 -0.014300 0.994
REACTOME ACTIVATION OF C3 AND C5 7 0.87000 0.035800 0.994
REACTOME GLUCOSE METABOLISM 15 0.87100 -0.024400 0.994
REACTOME SIGNALING BY NUCLEAR RECEPTORS 24 0.87300 -0.019100 0.994
REACTOME DISEASES OF METABOLISM 32 0.87900 0.015800 0.994
REACTOME CDC42 GTPASE CYCLE 8 0.88400 0.029900 0.994
REACTOME HEDGEHOG ON STATE 14 0.88700 0.022200 0.994
REACTOME SARS COV 1 INFECTION 16 0.88900 -0.020300 0.994
REACTOME VESICLE MEDIATED TRANSPORT 129 0.89000 0.007630 0.994
REACTOME ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 37 0.89200 -0.013100 0.994
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 38 0.89400 -0.012800 0.994
REACTOME SIGNAL TRANSDUCTION BY L1 8 0.89700 0.026500 0.994
REACTOME SEPARATION OF SISTER CHROMATIDS 18 0.89900 0.017400 0.994
REACTOME L1CAM INTERACTIONS 27 0.90000 0.014100 0.994
REACTOME ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 5 0.90100 0.032300 0.994
REACTOME CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 5 0.90100 0.032300 0.994
REACTOME GAP JUNCTION ASSEMBLY 5 0.90100 0.032300 0.994
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY 5 0.90100 0.032300 0.994
REACTOME SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 5 0.90100 0.032300 0.994
REACTOME TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 5 0.90100 0.032300 0.994
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 7 0.90100 0.027200 0.994
REACTOME SIGNALING BY TGFB FAMILY MEMBERS 16 0.90300 0.017700 0.994
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 5 0.90600 -0.030500 0.994
REACTOME SIGNALING BY NOTCH1 5 0.90600 -0.030500 0.994
REACTOME RHOD GTPASE CYCLE 8 0.91100 -0.022900 0.994
REACTOME CELL CYCLE CHECKPOINTS 18 0.91400 0.014900 0.994
REACTOME PHASE I FUNCTIONALIZATION OF COMPOUNDS 10 0.91500 -0.019700 0.994
REACTOME CHL1 INTERACTIONS 6 0.91600 0.024900 0.994
REACTOME RHO GTPASES ACTIVATE FORMINS 13 0.91700 0.016800 0.994
REACTOME APOPTOTIC EXECUTION PHASE 10 0.91900 0.018800 0.994
REACTOME DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 5 0.91900 -0.026500 0.994
REACTOME RHOG GTPASE CYCLE 9 0.92000 -0.019500 0.994
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 7 0.92100 -0.021800 0.994
REACTOME MHC CLASS II ANTIGEN PRESENTATION 18 0.92200 0.013400 0.994
REACTOME GOLGI TO ER RETROGRADE TRANSPORT 15 0.92300 -0.014600 0.994
REACTOME RHOF GTPASE CYCLE 9 0.92600 0.018000 0.994
REACTOME DENGUE VIRUS ATTACHMENT AND ENTRY 7 0.92800 -0.019900 0.994
REACTOME CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 5 0.92800 0.023400 0.994
REACTOME G2 M DNA DAMAGE CHECKPOINT 5 0.92800 0.023400 0.994
REACTOME SARS COV 2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS 5 0.92800 0.023400 0.994
REACTOME COPII MEDIATED VESICLE TRANSPORT 9 0.93500 -0.015800 0.996
REACTOME FC EPSILON RECEPTOR FCERI SIGNALING 52 0.93700 -0.006500 0.996
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 28 0.94000 -0.008320 0.996
REACTOME REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 8 0.94200 0.015100 0.996
REACTOME BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 65 0.94300 -0.005340 0.996
REACTOME DISEASES OF IMMUNE SYSTEM 6 0.94500 -0.016300 0.996
REACTOME IRAK4 DEFICIENCY TLR2 4 6 0.94500 -0.016300 0.996
REACTOME PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 5 0.94600 0.017600 0.996
REACTOME CD22 MEDIATED BCR REGULATION 34 0.94800 0.006630 0.996
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 5 0.95300 0.015400 0.997
REACTOME COLLAGEN FORMATION 12 0.95500 0.009530 0.997
REACTOME G ALPHA 12 13 SIGNALLING EVENTS 5 0.95600 -0.014500 0.997
REACTOME PKR MEDIATED SIGNALING 7 0.95700 -0.011900 0.997
REACTOME AUTOPHAGY 19 0.96600 0.005770 0.999
REACTOME GPCR LIGAND BINDING 15 0.96800 0.006070 0.999
REACTOME DISEASES OF HEMOSTASIS 14 0.96800 0.006260 0.999
REACTOME ANTIMICROBIAL MECHANISM OF IFN STIMULATED GENES 10 0.97000 -0.006940 0.999
REACTOME PROGRAMMED CELL DEATH 33 0.97300 -0.003440 0.999
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 49 0.97400 -0.002790 0.999
REACTOME IRON UPTAKE AND TRANSPORT 8 0.97600 -0.006140 0.999
REACTOME COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 11 0.97800 -0.004780 0.999
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 147 0.97800 0.001410 0.999
REACTOME INTERLEUKIN 1 FAMILY SIGNALING 15 0.98500 0.002770 0.999
REACTOME INTERLEUKIN 1 SIGNALING 15 0.98500 0.002770 0.999
REACTOME MEMBRANE TRAFFICKING 67 0.98600 -0.001270 0.999
REACTOME APOPTOSIS 29 0.98800 0.001690 0.999
REACTOME SIGNALING BY NTRKS 7 0.99100 0.002390 0.999
REACTOME AURKA ACTIVATION BY TPX2 8 0.99100 0.002230 0.999
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 8 0.99100 0.002230 0.999
REACTOME CELL CYCLE 33 0.99300 0.000870 0.999
REACTOME CLASS A 1 RHODOPSIN LIKE RECEPTORS 11 0.99600 0.000916 0.999
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 11 0.99600 0.000916 0.999
REACTOME COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 9 0.99800 -0.000372 0.999
REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 11 0.99900 -0.000305 0.999


Detailed Gene set reports



REACTOME_METABOLISM_OF_LIPIDS
set REACTOME_METABOLISM_OF_LIPIDS
setSize 30
pANOVA 0.00174
s.dist -0.335
p.adjustANOVA 0.423


Top enriched genes
Top 20 genes
GeneID Gene Rank
GPX1 -395
APOA1 -389
ALB -365
MGLL -355
DECR1 -346
PON1 -336
RAB14 -318
PIP4K2A -317
ACLY -292
TSPO -290
ARF3 -282
GC -253
APOA2 -247
HEXB -217
TBXAS1 -166
PTGS1 -134
PPP1CA -112
GBA1 -88
DPEP2 -43
PON3 11

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPX1 -395
APOA1 -389
ALB -365
MGLL -355
DECR1 -346
PON1 -336
RAB14 -318
PIP4K2A -317
ACLY -292
TSPO -290
ARF3 -282
GC -253
APOA2 -247
HEXB -217
TBXAS1 -166
PTGS1 -134
PPP1CA -112
GBA1 -88
DPEP2 -43
PON3 11
FABP5 17
EPHX2 20
SERPINA6 30
RAN 147
LTA4H 177
APOA5 182
PTGDS 238
BCHE 262
AGT 349
GM2A 482


REACTOME_PEPTIDE_HORMONE_METABOLISM
set REACTOME_PEPTIDE_HORMONE_METABOLISM
setSize 15
pANOVA 0.00405
s.dist 0.432
p.adjustANOVA 0.423


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGF1 488
CTSZ 479
GNB1 417
AGT 349
INHBE 290
CPB2 279
BCHE 262
CTSD 256
ACE 169
PLA2G7 158
DPP4 149
INHBC 140
ANPEP 139
P4HB 99
CES1 -113

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGF1 488
CTSZ 479
GNB1 417
AGT 349
INHBE 290
CPB2 279
BCHE 262
CTSD 256
ACE 169
PLA2G7 158
DPP4 149
INHBC 140
ANPEP 139
P4HB 99
CES1 -113


REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE
set REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE
setSize 28
pANOVA 0.00411
s.dist 0.318
p.adjustANOVA 0.423


Top enriched genes
Top 20 genes
GeneID Gene Rank
PKP1 469
KRT71 398
FLG 366
KRT77 365
KRT6C 332
DSP 318
JUP 305
DSG1 302
CAPN1 301
KRT17 298
CASP14 287
KRT9 286
KRT78 260
KRT14 257
KRT5 253
DSC1 237
KRT16 191
KRT1 181
EVPL 166
KRT6A 157

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PKP1 469
KRT71 398
FLG 366
KRT77 365
KRT6C 332
DSP 318
JUP 305
DSG1 302
CAPN1 301
KRT17 298
CASP14 287
KRT9 286
KRT78 260
KRT14 257
KRT5 253
DSC1 237
KRT16 191
KRT1 181
EVPL 166
KRT6A 157
KRT80 107
KRT2 12
KRT10 1
DSG2 -48
SPINK5 -62
CSTA -128
CAPNS1 -138
TGM1 -302


REACTOME_KERATINIZATION
set REACTOME_KERATINIZATION
setSize 28
pANOVA 0.00411
s.dist 0.318
p.adjustANOVA 0.423


Top enriched genes
Top 20 genes
GeneID Gene Rank
PKP1 469
KRT71 398
FLG 366
KRT77 365
KRT6C 332
DSP 318
JUP 305
DSG1 302
CAPN1 301
KRT17 298
CASP14 287
KRT9 286
KRT78 260
KRT14 257
KRT5 253
DSC1 237
KRT16 191
KRT1 181
EVPL 166
KRT6A 157

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PKP1 469
KRT71 398
FLG 366
KRT77 365
KRT6C 332
DSP 318
JUP 305
DSG1 302
CAPN1 301
KRT17 298
CASP14 287
KRT9 286
KRT78 260
KRT14 257
KRT5 253
DSC1 237
KRT16 191
KRT1 181
EVPL 166
KRT6A 157
KRT80 107
KRT2 12
KRT10 1
DSG2 -48
SPINK5 -62
CSTA -128
CAPNS1 -138
TGM1 -302


REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN
set REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN
setSize 10
pANOVA 0.00444
s.dist -0.522
p.adjustANOVA 0.423


Top enriched genes
Top 20 genes
GeneID Gene Rank
FYN -374
ITGA2 -358
GP1BA -353
ITGB1 -256
FCER1G -244
GP1BB -198
ADAMTS13 -129
GP5 -122
GP9 25
VWF 131

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FYN -374
ITGA2 -358
GP1BA -353
ITGB1 -256
FCER1G -244
GP1BB -198
ADAMTS13 -129
GP5 -122
GP9 25
VWF 131


REACTOME_SYNDECAN_INTERACTIONS
set REACTOME_SYNDECAN_INTERACTIONS
setSize 10
pANOVA 0.00535
s.dist -0.511
p.adjustANOVA 0.423


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGA6 -399
ITGA2 -358
ITGB1 -256
TGFB1 -226
THBS1 -200
TNC -144
ITGB3 -100
ACTN1 -97
VTN -25
FN1 -24

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA6 -399
ITGA2 -358
ITGB1 -256
TGFB1 -226
THBS1 -200
TNC -144
ITGB3 -100
ACTN1 -97
VTN -25
FN1 -24


REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS
set REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS
setSize 9
pANOVA 0.00594
s.dist -0.532
p.adjustANOVA 0.423


Top enriched genes
Top 20 genes
GeneID Gene Rank
NOTCH1 -359
DAG1 -320
SPON1 -315
NOTCH2 -233
THBS1 -200
B4GAT1 -191
ADAMTS13 -129
NOTCH3 -94
CFP 109

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH1 -359
DAG1 -320
SPON1 -315
NOTCH2 -233
THBS1 -200
B4GAT1 -191
ADAMTS13 -129
NOTCH3 -94
CFP 109


REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS
set REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS
setSize 19
pANOVA 0.0066
s.dist -0.363
p.adjustANOVA 0.423


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGA6 -399
ITGA2 -358
LAMC1 -348
DAG1 -320
ITGB1 -256
TGFB1 -226
THBS1 -200
TNC -144
ACTB -110
ITGB3 -100
ACTN1 -97
VTN -25
FN1 -24
HSPG2 -15
TTR -7
ACTC1 4
LAMB1 29
LAMA2 34
COL4A1 371

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA6 -399
ITGA2 -358
LAMC1 -348
DAG1 -320
ITGB1 -256
TGFB1 -226
THBS1 -200
TNC -144
ACTB -110
ITGB3 -100
ACTN1 -97
VTN -25
FN1 -24
HSPG2 -15
TTR -7
ACTC1 4
LAMB1 29
LAMA2 34
COL4A1 371


REACTOME_NEUTROPHIL_DEGRANULATION
set REACTOME_NEUTROPHIL_DEGRANULATION
setSize 152
pANOVA 0.00742
s.dist 0.137
p.adjustANOVA 0.423


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 497
PRCP 490
GM2A 482
PSMD3 480
CTSZ 479
CSTB 476
ELANE 475
HP 473
B4GALT1 470
PKP1 469
GPI 468
LILRA3 467
RAP1B 465
DIAPH1 463
MLEC 462
CAT 453
CHI3L1 435
LAMP2 431
RAB10 427
AHSG 422

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 497
PRCP 490
GM2A 482
PSMD3 480
CTSZ 479
CSTB 476
ELANE 475
HP 473
B4GALT1 470
PKP1 469
GPI 468
LILRA3 467
RAP1B 465
DIAPH1 463
MLEC 462
CAT 453
CHI3L1 435
LAMP2 431
RAB10 427
AHSG 422
OSCAR 418
FGL2 413
TXNDC5 402
ADA2 394
CD44 389
SERPINB12 383
IDH1 382
PSMD2 380
PIGR 378
PGM1 377
B2M 376
CAMP 375
IQGAP2 374
CST3 351
LYZ 347
GRN 342
GGH 339
CFD 325
HRNR 323
LGALS3 320
DSP 318
SERPINA3 307
JUP 305
PRSS3 303
DSG1 302
CAPN1 301
PTPRJ 297
CTSS 293
HBB 283
ALAD 275
ORM1 270
BST1 263
MMP9 261
PNP 258
CTSD 256
LTF 255
TIMP2 247
DSC1 237
IGF2R 236
ORM2 232
QSOX1 231
TUBB4B 230
DBNL 224
PTPRC 212
KRT1 181
LTA4H 177
NME2 173
PRDX6 170
ARPC5 164
SERPINA1 156
LRG1 152
TUBB 148
FCN1 145
ANPEP 139
PRG2 138
CD14 130
CRISP3 114
RAB6A 110
CFP 109
PSMA5 108
CTSH 106
ACTR2 105
VAT1 102
CTSC 73
ALDOA 68
FUCA2 63
ERP44 61
SIRPA 54
ITGB2 49
HSPA8 36
RAB7A 23
FABP5 17
A1BG 16
PFKL 6
LCN2 5
FLG2 0
PA2G4 -3
PKM -5
TTR -7
VCL -11
FTL -33
ALDOC -38
CD93 -41
HSPA1A -55
SELL -63
DYNC1H1 -68
FUCA1 -69
SNAP23 -72
VCP -82
PYGL -89
PGAM1 -101
C3 -102
HLA-C -125
HSP90AA1 -126
GDI2 -133
VNN1 -148
SLPI -153
FTH1 -156
PPIA -158
CAP1 -159
S100A7 -186
BIN2 -195
STOM -209
PYGB -212
GSN -214
HEXB -217
SERPINB1 -218
CCT2 -222
FCER1G -244
COTL1 -251
GSTP1 -267
PPBP -269
HSP90AB1 -272
EEF1A1 -277
ANO6 -289
CALML5 -291
ACLY -292
AGA -308
PECAM1 -309
CNN2 -312
RAB14 -318
CYB5R3 -323
ARG1 -335
ANXA2 -345
PSMB7 -361
HLA-B -362
S100A8 -372
CCT8 -379
ADAM10 -382
S100A9 -383
CTSB -387
RNASE2 -400


REACTOME_MITOCHONDRIAL_PROTEIN_DEGRADATION
set REACTOME_MITOCHONDRIAL_PROTEIN_DEGRADATION
setSize 6
pANOVA 0.00914
s.dist -0.616
p.adjustANOVA 0.45


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPD1 -397
IDH2 -376
ATP5F1B -341
ATP5F1A -239
ACO2 -104
APP 70

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPD1 -397
IDH2 -376
ATP5F1B -341
ATP5F1A -239
ACO2 -104
APP 70


REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE
set REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE
setSize 7
pANOVA 0.0104
s.dist -0.561
p.adjustANOVA 0.45


Top enriched genes
Top 20 genes
GeneID Gene Rank
FYN -374
MYL9 -280
SRC -275
ROCK2 -254
MYL6 -157
MYH9 -99
MYL12B -4

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FYN -374
MYL9 -280
SRC -275
ROCK2 -254
MYL6 -157
MYH9 -99
MYL12B -4


REACTOME_INNATE_IMMUNE_SYSTEM
set REACTOME_INNATE_IMMUNE_SYSTEM
setSize 266
pANOVA 0.0107
s.dist 0.108
p.adjustANOVA 0.45


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 497
PRCP 490
CFHR2 485
GM2A 482
PSMD3 480
CTSZ 479
CSTB 476
ELANE 475
HP 473
B4GALT1 470
PKP1 469
GPI 468
LILRA3 467
RAP1B 465
DIAPH1 463
MLEC 462
IGLV7-43 459
CAT 453
CFHR4 451
CHI3L1 435

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 497
PRCP 490
CFHR2 485
GM2A 482
PSMD3 480
CTSZ 479
CSTB 476
ELANE 475
HP 473
B4GALT1 470
PKP1 469
GPI 468
LILRA3 467
RAP1B 465
DIAPH1 463
MLEC 462
IGLV7-43 459
CAT 453
CFHR4 451
CHI3L1 435
CFHR1 432
LAMP2 431
IGHV1-46 428
RAB10 427
AHSG 422
IGLV3-19 421
OSCAR 418
FGL2 413
CFL1 412
TXNDC5 402
IGLV2-8 401
ADA2 394
CD44 389
SERPINB12 383
IDH1 382
PSMD2 380
PIGR 378
PGM1 377
B2M 376
CAMP 375
IQGAP2 374
GRB2 364
IGHV3-48 362
COLEC10 361
CPN1 359
MASP2 353
PRKCSH 352
CST3 351
LYZ 347
FGB 344
GRN 342
GGH 339
CFH 334
CFD 325
HRNR 323
LGALS3 320
DSP 318
C4BPA 317
C2 311
IGLV1-44 309
SERPINA3 307
JUP 305
RPS27A 304
PRSS3 303
DSG1 302
CAPN1 301
IGLV1-40 300
IGHV3-13 299
PTPRJ 297
CTSS 293
FGA 292
C4BPB 289
HBB 283
CPB2 279
ALAD 275
CFB 272
ORM1 270
BST1 263
MMP9 261
PNP 258
CTSD 256
LTF 255
TIMP2 247
C9 243
DSC1 237
IGF2R 236
ORM2 232
QSOX1 231
TUBB4B 230
DBNL 224
COLEC11 219
FGG 218
PTPRC 212
C1QC 208
IGHV3-7 203
MASP1 200
CRP 199
CFHR5 197
SAA1 192
C6 189
MBL2 188
IGHV3-23 186
SERPING1 184
KRT1 181
IGHE 179
LTA4H 177
NME2 173
C1QA 171
PRDX6 170
PSMA4 167
ARPC5 164
SERPINA1 156
LRG1 152
TUBB 148
IGLV6-57 146
FCN1 145
IGHV4-34 144
ANPEP 139
PRG2 138
FCN3 134
CD14 130
IGHV1-69 129
C8G 127
PSMA7 125
IGLV2-11 119
IGLV2-14 116
C4B 115
CRISP3 114
IGKV3-11 113
IGKV1D-33 111
RAB6A 110
CFP 109
PSMA5 108
CTSH 106
ACTR2 105
VAT1 102
C7 88
UBE2V1 85
IGKV4-1 81
LBP 79
C8B 78
CFI 76
TXN 75
CTSC 73
APP 70
ALDOA 68
PROS1 67
FUCA2 63
ERP44 61
FCGR3A 59
C1S 57
SYK 55
SIRPA 54
IGLV1-47 52
ITGB2 49
C5 48
FCN2 45
C8A 43
HSPA8 36
IGLV1-51 28
RAB7A 23
FABP5 17
A1BG 16
PFKL 6
LCN2 5
FLG2 0
PA2G4 -3
PKM -5
TTR -7
VCL -11
IGHV2-70 -13
C1R -16
VTN -25
BPIFB1 -26
C1QB -28
FTL -33
ALDOC -38
CD93 -41
IGHV3-30 -47
ACTR3 -54
HSPA1A -55
SELL -63
CLU -65
DYNC1H1 -68
FUCA1 -69
SNAP23 -72
ARPC3 -73
PGLYRP2 -76
CPN2 -80
HSP90B1 -81
VCP -82
IGHG2 -84
PYGL -89
IGHV2-5 -93
MYH9 -99
PGAM1 -101
C3 -102
ACTB -110
HLA-C -125
HSP90AA1 -126
GDI2 -133
PSMA1 -141
IGKV1-17 -146
VNN1 -148
SLPI -153
FTH1 -156
PPIA -158
CAP1 -159
F2 -169
CALM1 -171
ARPC2 -176
IGHG4 -184
S100A7 -186
IGHV1-2 -188
BIN2 -195
PSMA6 -205
IGKV1-16 -208
STOM -209
PYGB -212
GSN -214
HEXB -217
SERPINB1 -218
CCT2 -222
ARPC1B -229
APOB -237
IGLC2 -240
FCER1G -244
COTL1 -251
PSMB2 -255
IGKV1-5 -260
CHGA -263
IGKV3D-20 -264
GSTP1 -267
PPBP -269
HSP90AB1 -272
SRC -275
EEF1A1 -277
ANO6 -289
CALML5 -291
ACLY -292
IGLV2-23 -295
ITLN1 -306
AGA -308
PECAM1 -309
CNN2 -312
RAB14 -318
C4A -322
CYB5R3 -323
PSMB3 -334
ARG1 -335
IGHG1 -338
IGKV3-20 -339
ANXA2 -345
IGKV1D-16 -349
PSMB7 -361
HLA-B -362
S100A8 -372
FYN -374
CCT8 -379
ADAM10 -382
S100A9 -383
CTSB -387
CAPZA1 -391
RNASE2 -400
RASGRP2 -402
ARPC4 -404


REACTOME_ERYTHROCYTES_TAKE_UP_CARBON_DIOXIDE_AND_RELEASE_OXYGEN
set REACTOME_ERYTHROCYTES_TAKE_UP_CARBON_DIOXIDE_AND_RELEASE_OXYGEN
setSize 5
pANOVA 0.0123
s.dist 0.648
p.adjustANOVA 0.45


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC4A1 408
CA2 395
HBA2 358
HBB 283
CA1 240

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC4A1 408
CA2 395
HBA2 358
HBB 283
CA1 240


REACTOME_ERYTHROCYTES_TAKE_UP_OXYGEN_AND_RELEASE_CARBON_DIOXIDE
set REACTOME_ERYTHROCYTES_TAKE_UP_OXYGEN_AND_RELEASE_CARBON_DIOXIDE
setSize 5
pANOVA 0.0123
s.dist 0.648
p.adjustANOVA 0.45


Top enriched genes
Top 20 genes
GeneID Gene Rank
SLC4A1 408
CA2 395
HBA2 358
HBB 283
CA1 240

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC4A1 408
CA2 395
HBA2 358
HBB 283
CA1 240


REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION
set REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION
setSize 5
pANOVA 0.0178
s.dist -0.613
p.adjustANOVA 0.586


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP1BA -353
MYL9 -280
PF4 -266
THBS1 -200
ITGA2B -52

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP1BA -353
MYL9 -280
PF4 -266
THBS1 -200
ITGA2B -52


REACTOME_DISEASES_OF_CARBOHYDRATE_METABOLISM
set REACTOME_DISEASES_OF_CARBOHYDRATE_METABOLISM
setSize 6
pANOVA 0.019
s.dist 0.555
p.adjustANOVA 0.586


Top enriched genes
Top 20 genes
GeneID Gene Rank
DCXR 437
HYAL1 404
ALDOB 340
RPS27A 304
NAGLU 284
TALDO1 -2

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DCXR 437
HYAL1 404
ALDOB 340
RPS27A 304
NAGLU 284
TALDO1 -2


REACTOME_CELLULAR_RESPONSES_TO_STIMULI
set REACTOME_CELLULAR_RESPONSES_TO_STIMULI
setSize 87
pANOVA 0.0194
s.dist -0.152
p.adjustANOVA 0.586


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPD1 -397
GPX1 -395
CAPZA1 -391
APOA1 -389
FYN -374
TUBA8 -366
ALB -365
PRDX5 -364
PSMB7 -361
NOTCH1 -359
PDIA5 -352
ANXA2 -345
PSMB3 -334
PRDX1 -332
PECAM1 -309
EEF1A1 -277
HSP90AB1 -272
STIP1 -271
GSTP1 -267
HSPA4 -265

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPD1 -397
GPX1 -395
CAPZA1 -391
APOA1 -389
FYN -374
TUBA8 -366
ALB -365
PRDX5 -364
PSMB7 -361
NOTCH1 -359
PDIA5 -352
ANXA2 -345
PSMB3 -334
PRDX1 -332
PECAM1 -309
EEF1A1 -277
HSP90AB1 -272
STIP1 -271
GSTP1 -267
HSPA4 -265
PRDX3 -262
GSR -261
FLT4 -258
ITGB1 -256
PSMB2 -255
PGD -238
APOB -237
GPX3 -231
GNB2 -211
PSMA6 -205
TKT -199
CALM1 -171
HSPB1 -168
PSMA1 -141
CAPNS1 -138
HSP90AA1 -126
CSRP1 -121
ITGB3 -100
TLN1 -85
VCP -82
HSP90B1 -81
DYNC1H1 -68
TUBA4A -57
HSPA1A -55
EXTL2 -46
HSPA5 -45
HYOU1 -36
G6PD -30
FN1 -24
HSPG2 -15
VCL -11
TALDO1 -2
TUBB1 22
CDH5 27
HSPA8 36
CALR 62
PDIA6 69
TXN 75
P4HB 99
PSMA5 108
YWHAE 112
PSMA7 125
HSPE1 151
PSMA4 167
PRDX6 170
TUBB4B 230
HBB 283
RPS27A 304
ST13 306
SOD3 329
PRKAR1A 336
SOD2 337
BLVRB 338
GNAQ 345
PRDX2 355
HBA2 358
PSMD2 380
IDH1 382
DPP3 385
GNB1 417
SOD1 433
CACNA2D1 452
CAT 453
ACTR1A 457
TUBA1C 471
PSMD3 480
MAPK1 497


REACTOME_RHOBTB_GTPASE_CYCLE
set REACTOME_RHOBTB_GTPASE_CYCLE
setSize 8
pANOVA 0.0217
s.dist -0.471
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBN1 -401
CCT6A -342
HSP90AB1 -272
ROCK2 -254
CCT2 -222
HSP90AA1 -126
ACTN1 -97
TXNL1 391

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBN1 -401
CCT6A -342
HSP90AB1 -272
ROCK2 -254
CCT2 -222
HSP90AA1 -126
ACTN1 -97
TXNL1 391


REACTOME_COMPLEMENT_CASCADE
set REACTOME_COMPLEMENT_CASCADE
setSize 80
pANOVA 0.0225
s.dist 0.154
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
CFHR2 485
ELANE 475
IGLV7-43 459
CFHR4 451
CFHR1 432
IGHV1-46 428
IGLV3-19 421
IGLV2-8 401
IGHV3-48 362
COLEC10 361
CPN1 359
MASP2 353
CFH 334
CFD 325
C4BPA 317
C2 311
IGLV1-44 309
IGLV1-40 300
IGHV3-13 299
C4BPB 289

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CFHR2 485
ELANE 475
IGLV7-43 459
CFHR4 451
CFHR1 432
IGHV1-46 428
IGLV3-19 421
IGLV2-8 401
IGHV3-48 362
COLEC10 361
CPN1 359
MASP2 353
CFH 334
CFD 325
C4BPA 317
C2 311
IGLV1-44 309
IGLV1-40 300
IGHV3-13 299
C4BPB 289
CPB2 279
CFB 272
C9 243
COLEC11 219
C1QC 208
IGHV3-7 203
MASP1 200
CRP 199
CFHR5 197
C6 189
MBL2 188
IGHV3-23 186
SERPING1 184
C1QA 171
IGLV6-57 146
FCN1 145
IGHV4-34 144
FCN3 134
IGHV1-69 129
C8G 127
IGLV2-11 119
IGLV2-14 116
C4B 115
IGKV3-11 113
IGKV1D-33 111
CFP 109
C7 88
IGKV4-1 81
C8B 78
CFI 76
PROS1 67
C1S 57
IGLV1-47 52
C5 48
FCN2 45
C8A 43
IGLV1-51 28
IGHV2-70 -13
C1R -16
VTN -25
C1QB -28
IGHV3-30 -47
CLU -65
CPN2 -80
IGHG2 -84
IGHV2-5 -93
C3 -102
IGKV1-17 -146
F2 -169
IGHG4 -184
IGHV1-2 -188
IGKV1-16 -208
IGLC2 -240
IGKV1-5 -260
IGKV3D-20 -264
IGLV2-23 -295
C4A -322
IGHG1 -338
IGKV3-20 -339
IGKV1D-16 -349


REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3
set REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3
setSize 70
pANOVA 0.0244
s.dist -0.162
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARPC4 -404
DBN1 -401
TPM3 -396
S100A9 -383
S100A8 -372
TUBA8 -366
CCT6A -342
FLOT2 -330
YWHAG -324
ARHGDIB -304
MYL9 -280
SRC -275
HSP90AB1 -272
STIP1 -271
ITGB1 -256
ROCK2 -254
BCAP31 -235
ARPC1B -229
CCT2 -222
STOM -209

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARPC4 -404
DBN1 -401
TPM3 -396
S100A9 -383
S100A8 -372
TUBA8 -366
CCT6A -342
FLOT2 -330
YWHAG -324
ARHGDIB -304
MYL9 -280
SRC -275
HSP90AB1 -272
STIP1 -271
ITGB1 -256
ROCK2 -254
BCAP31 -235
ARPC1B -229
CCT2 -222
STOM -209
TPM4 -179
ARPC2 -176
CALM1 -171
MYL6 -157
CTTN -150
PFN1 -145
HSP90AA1 -126
ACTB -110
MYH9 -99
BASP1 -98
ACTN1 -97
VCP -82
PLXNB1 -79
ARPC3 -73
SNAP23 -72
AKAP12 -71
DYNC1H1 -68
TUBA4A -57
ACTR3 -54
TFRC -53
FLNA -51
DSG2 -48
MYL12B -4
YWHAZ 3
ACTC1 4
TUBB1 22
RAB7A 23
MCAM 37
YWHAB 60
ACTR2 105
YWHAE 112
HSPE1 151
ARPC5 164
CLTC 178
CDH1 209
TUBB4B 230
DSG1 302
JUP 305
DSP 318
RHOC 322
GRB2 364
IQGAP2 374
TXNL1 391
ARHGAP1 407
CFL1 412
YWHAH 429
KIF2A 458
DIAPH1 463
TUBA1C 471
MAPK1 497


REACTOME_MUSCLE_CONTRACTION
set REACTOME_MUSCLE_CONTRACTION
setSize 16
pANOVA 0.0258
s.dist -0.325
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
TPM3 -396
ANXA2 -345
MYL9 -280
TTN -187
TPM4 -179
CALM1 -171
MYL6 -157
ATP2A3 -119
CES1 -113
TLN1 -85
CALD1 -18
VCL -11
MYL12B -4
ACTC1 4
ANXA1 46
TPM1 436

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TPM3 -396
ANXA2 -345
MYL9 -280
TTN -187
TPM4 -179
CALM1 -171
MYL6 -157
ATP2A3 -119
CES1 -113
TLN1 -85
CALD1 -18
VCL -11
MYL12B -4
ACTC1 4
ANXA1 46
TPM1 436


REACTOME_EPH_EPHRIN_SIGNALING
set REACTOME_EPH_EPHRIN_SIGNALING
setSize 20
pANOVA 0.026
s.dist -0.291
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARPC4 -404
ADAM10 -382
FYN -374
MYL9 -280
SRC -275
ROCK2 -254
ARPC1B -229
ARPC2 -176
MYL6 -157
ACTB -110
MYH9 -99
ARPC3 -73
ACTR3 -54
MYL12B -4
MMP2 91
ACTR2 105
ARPC5 164
CLTC 178
MMP9 261
CFL1 412

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARPC4 -404
ADAM10 -382
FYN -374
MYL9 -280
SRC -275
ROCK2 -254
ARPC1B -229
ARPC2 -176
MYL6 -157
ACTB -110
MYH9 -99
ARPC3 -73
ACTR3 -54
MYL12B -4
MMP2 91
ACTR2 105
ARPC5 164
CLTC 178
MMP9 261
CFL1 412


REACTOME_SCAVENGING_BY_CLASS_B_RECEPTORS
set REACTOME_SCAVENGING_BY_CLASS_B_RECEPTORS
setSize 7
pANOVA 0.0287
s.dist -0.479
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
APOA1 -389
S100A9 -383
PRDX1 -332
APOB -237
CD5L -180
SSC5D 143
SAA1 192

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOA1 -389
S100A9 -383
PRDX1 -332
APOB -237
CD5L -180
SSC5D 143
SAA1 192


REACTOME_LYSOSOME_VESICLE_BIOGENESIS
set REACTOME_LYSOSOME_VESICLE_BIOGENESIS
setSize 6
pANOVA 0.0295
s.dist 0.515
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARRB1 495
CTSZ 479
TXNDC5 402
CLTC 178
APP 70
HSPA8 36

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARRB1 495
CTSZ 479
TXNDC5 402
CLTC 178
APP 70
HSPA8 36


REACTOME_FOLDING_OF_ACTIN_BY_CCT_TRIC
set REACTOME_FOLDING_OF_ACTIN_BY_CCT_TRIC
setSize 6
pANOVA 0.0297
s.dist -0.514
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCT8 -379
CCT6A -342
CCT2 -222
CCT5 -201
ACTB -110
TCP1 142

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT8 -379
CCT6A -342
CCT2 -222
CCT5 -201
ACTB -110
TCP1 142


REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS
set REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS
setSize 6
pANOVA 0.0324
s.dist -0.506
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCT8 -379
CCT6A -342
CCT2 -222
CCT5 -201
GBA1 -88
TCP1 142

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT8 -379
CCT6A -342
CCT2 -222
CCT5 -201
GBA1 -88
TCP1 142


REACTOME_SENSORY_PROCESSING_OF_SOUND
set REACTOME_SENSORY_PROCESSING_OF_SOUND
setSize 5
pANOVA 0.0325
s.dist -0.554
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
CAPZA1 -391
GSN -214
MSN -203
ACTB -110
MYH9 -99

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CAPZA1 -391
GSN -214
MSN -203
ACTB -110
MYH9 -99


REACTOME_PHOSPHOLIPID_METABOLISM
set REACTOME_PHOSPHOLIPID_METABOLISM
setSize 5
pANOVA 0.0335
s.dist -0.551
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
MGLL -355
RAB14 -318
PIP4K2A -317
ARF3 -282
BCHE 262

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MGLL -355
RAB14 -318
PIP4K2A -317
ARF3 -282
BCHE 262


REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC
set REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC
setSize 10
pANOVA 0.0347
s.dist -0.388
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
HLA-A -392
CANX -363
HLA-B -362
BCAP31 -235
ERAP2 -173
HLA-C -125
HSPA5 -45
PDIA3 -21
CALR 62
B2M 376

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HLA-A -392
CANX -363
HLA-B -362
BCAP31 -235
ERAP2 -173
HLA-C -125
HSPA5 -45
PDIA3 -21
CALR 62
B2M 376


REACTOME_MITOCHONDRIAL_BIOGENESIS
set REACTOME_MITOCHONDRIAL_BIOGENESIS
setSize 6
pANOVA 0.0349
s.dist -0.499
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
IDH2 -376
ATP5F1B -341
ATP5PB -281
ATP5F1A -239
CALM1 -171
SOD2 337

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IDH2 -376
ATP5F1B -341
ATP5PB -281
ATP5F1A -239
CALM1 -171
SOD2 337


REACTOME_FATTY_ACID_METABOLISM
set REACTOME_FATTY_ACID_METABOLISM
setSize 11
pANOVA 0.0401
s.dist -0.36
p.adjustANOVA 0.649


Top enriched genes
Top 20 genes
GeneID Gene Rank
GPX1 -395
DECR1 -346
PON1 -336
ACLY -292
TBXAS1 -166
PTGS1 -134
DPEP2 -43
PON3 11
EPHX2 20
LTA4H 177
PTGDS 238

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPX1 -395
DECR1 -346
PON1 -336
ACLY -292
TBXAS1 -166
PTGS1 -134
DPEP2 -43
PON3 11
EPHX2 20
LTA4H 177
PTGDS 238


REACTOME_MET_ACTIVATES_PTK2_SIGNALING
set REACTOME_MET_ACTIVATES_PTK2_SIGNALING
setSize 8
pANOVA 0.0405
s.dist -0.42
p.adjustANOVA 0.649


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGA2 -358
LAMC1 -348
SRC -275
ITGB1 -256
FN1 -24
LAMB1 29
LAMA2 34
MET 56

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA2 -358
LAMC1 -348
SRC -275
ITGB1 -256
FN1 -24
LAMB1 29
LAMA2 34
MET 56


REACTOME_EPHB_MEDIATED_FORWARD_SIGNALING
set REACTOME_EPHB_MEDIATED_FORWARD_SIGNALING
setSize 12
pANOVA 0.0434
s.dist -0.339
p.adjustANOVA 0.659


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARPC4 -404
FYN -374
SRC -275
ROCK2 -254
ARPC1B -229
ARPC2 -176
ACTB -110
ARPC3 -73
ACTR3 -54
ACTR2 105
ARPC5 164
CFL1 412

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARPC4 -404
FYN -374
SRC -275
ROCK2 -254
ARPC1B -229
ARPC2 -176
ACTB -110
ARPC3 -73
ACTR3 -54
ACTR2 105
ARPC5 164
CFL1 412


REACTOME_RHOBTB2_GTPASE_CYCLE
set REACTOME_RHOBTB2_GTPASE_CYCLE
setSize 7
pANOVA 0.0437
s.dist -0.442
p.adjustANOVA 0.659


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBN1 -401
CCT6A -342
HSP90AB1 -272
CCT2 -222
HSP90AA1 -126
ACTN1 -97
TXNL1 391

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBN1 -401
CCT6A -342
HSP90AB1 -272
CCT2 -222
HSP90AA1 -126
ACTN1 -97
TXNL1 391


REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS
set REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS
setSize 9
pANOVA 0.0452
s.dist -0.387
p.adjustANOVA 0.663


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGB1 -256
RSU1 -245
PARVB -236
LIMS1 -177
ACTB -110
ACTN1 -97
VASP -59
FLNA -51
ILK 80

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGB1 -256
RSU1 -245
PARVB -236
LIMS1 -177
ACTB -110
ACTN1 -97
VASP -59
FLNA -51
ILK 80


REACTOME_SMOOTH_MUSCLE_CONTRACTION
set REACTOME_SMOOTH_MUSCLE_CONTRACTION
setSize 12
pANOVA 0.057
s.dist -0.32
p.adjustANOVA 0.812


Top enriched genes
Top 20 genes
GeneID Gene Rank
TPM3 -396
ANXA2 -345
MYL9 -280
TPM4 -179
CALM1 -171
MYL6 -157
TLN1 -85
CALD1 -18
VCL -11
MYL12B -4
ANXA1 46
TPM1 436

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TPM3 -396
ANXA2 -345
MYL9 -280
TPM4 -179
CALM1 -171
MYL6 -157
TLN1 -85
CALD1 -18
VCL -11
MYL12B -4
ANXA1 46
TPM1 436


REACTOME_RHO_GTPASE_CYCLE
set REACTOME_RHO_GTPASE_CYCLE
setSize 38
pANOVA 0.0683
s.dist -0.175
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBN1 -401
TPM3 -396
CCT6A -342
FLOT2 -330
ARHGDIB -304
SRC -275
HSP90AB1 -272
STIP1 -271
ITGB1 -256
ROCK2 -254
BCAP31 -235
CCT2 -222
STOM -209
TPM4 -179
HSP90AA1 -126
ACTB -110
BASP1 -98
ACTN1 -97
VCP -82
PLXNB1 -79

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBN1 -401
TPM3 -396
CCT6A -342
FLOT2 -330
ARHGDIB -304
SRC -275
HSP90AB1 -272
STIP1 -271
ITGB1 -256
ROCK2 -254
BCAP31 -235
CCT2 -222
STOM -209
TPM4 -179
HSP90AA1 -126
ACTB -110
BASP1 -98
ACTN1 -97
VCP -82
PLXNB1 -79
SNAP23 -72
AKAP12 -71
TFRC -53
DSG2 -48
ACTC1 4
RAB7A 23
MCAM 37
HSPE1 151
CLTC 178
DSG1 302
JUP 305
DSP 318
RHOC 322
GRB2 364
IQGAP2 374
TXNL1 391
ARHGAP1 407
DIAPH1 463


REACTOME_ECM_PROTEOGLYCANS
set REACTOME_ECM_PROTEOGLYCANS
setSize 23
pANOVA 0.0685
s.dist -0.222
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGA2 -358
LAMC1 -348
DAG1 -320
ITGB1 -256
TGFB1 -226
SPARC -170
TNC -144
ITGB3 -100
TNXB -77
COL6A1 -60
ITGA2B -52
VTN -25
FN1 -24
COMP -23
HSPG2 -15
LUM 8
LAMB1 29
LAMA2 34
NCAM1 44
APP 70

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA2 -358
LAMC1 -348
DAG1 -320
ITGB1 -256
TGFB1 -226
SPARC -170
TNC -144
ITGB3 -100
TNXB -77
COL6A1 -60
ITGA2B -52
VTN -25
FN1 -24
COMP -23
HSPG2 -15
LUM 8
LAMB1 29
LAMA2 34
NCAM1 44
APP 70
COL6A3 216
SERPINE1 221
COL4A1 371


REACTOME_RHOH_GTPASE_CYCLE
set REACTOME_RHOH_GTPASE_CYCLE
setSize 8
pANOVA 0.0686
s.dist -0.374
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBN1 -401
ARHGDIB -304
ROCK2 -254
STOM -209
VCP -82
TFRC -53
RAB7A 23
JUP 305

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBN1 -401
ARHGDIB -304
ROCK2 -254
STOM -209
VCP -82
TFRC -53
RAB7A 23
JUP 305


REACTOME_METABOLISM_OF_ANGIOTENSINOGEN_TO_ANGIOTENSINS
set REACTOME_METABOLISM_OF_ANGIOTENSINOGEN_TO_ANGIOTENSINS
setSize 7
pANOVA 0.0716
s.dist 0.395
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
CTSZ 479
AGT 349
CPB2 279
CTSD 256
ACE 169
ANPEP 139
CES1 -113

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CTSZ 479
AGT 349
CPB2 279
CTSD 256
ACE 169
ANPEP 139
CES1 -113


REACTOME_RHO_GTPASES_ACTIVATE_PAKS
set REACTOME_RHO_GTPASES_ACTIVATE_PAKS
setSize 7
pANOVA 0.0737
s.dist -0.392
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
MYL9 -280
CALM1 -171
MYL6 -157
CTTN -150
MYH9 -99
FLNA -51
MYL12B -4

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYL9 -280
CALM1 -171
MYL6 -157
CTTN -150
MYH9 -99
FLNA -51
MYL12B -4


REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS
set REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS
setSize 5
pANOVA 0.0767
s.dist 0.459
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
SPTB 384
SPTA1 368
ANK1 331
L1CAM 285
ACTB -110

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SPTB 384
SPTA1 368
ANK1 331
L1CAM 285
ACTB -110


REACTOME_SIGNALING_BY_VEGF
set REACTOME_SIGNALING_BY_VEGF
setSize 13
pANOVA 0.0781
s.dist -0.284
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
FYN -374
SRC -275
FLT4 -258
ROCK2 -254
CALM1 -171
HSPB1 -168
HSP90AA1 -126
ACTB -110
ITGB3 -100
CDH5 27
NRP2 183
NRP1 266
JUP 305

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FYN -374
SRC -275
FLT4 -258
ROCK2 -254
CALM1 -171
HSPB1 -168
HSP90AA1 -126
ACTB -110
ITGB3 -100
CDH5 27
NRP2 183
NRP1 266
JUP 305


REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS
set REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS
setSize 5
pANOVA 0.0791
s.dist 0.455
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
PKP1 469
DSP 318
DSG1 302
CDH1 209
DSG2 -48

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PKP1 469
DSP 318
DSG1 302
CDH1 209
DSG2 -48


REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION
set REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION
setSize 8
pANOVA 0.0815
s.dist 0.357
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
COLEC10 361
MASP2 353
COLEC11 219
MASP1 200
MBL2 188
FCN1 145
FCN3 134
FCN2 45

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COLEC10 361
MASP2 353
COLEC11 219
MASP1 200
MBL2 188
FCN1 145
FCN3 134
FCN2 45


REACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE
set REACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE
setSize 24
pANOVA 0.0835
s.dist -0.207
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCT8 -379
IDH2 -376
TUBA8 -366
ATP5F1B -341
YWHAG -324
ATP5PB -281
RAB11A -273
ATP5F1A -239
CCT2 -222
CCT5 -201
CALM1 -171
HSP90AA1 -126
DYNC1H1 -68
TUBA4A -57
RAB8A -31
TUBB1 22
YWHAE 112
TCP1 142
TUBB 148
TUBB4B 230

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT8 -379
IDH2 -376
TUBA8 -366
ATP5F1B -341
YWHAG -324
ATP5PB -281
RAB11A -273
ATP5F1A -239
CCT2 -222
CCT5 -201
CALM1 -171
HSP90AA1 -126
DYNC1H1 -68
TUBA4A -57
RAB8A -31
TUBB1 22
YWHAE 112
TCP1 142
TUBB 148
TUBB4B 230
SOD2 337
ARF4 444
ACTR1A 457
TUBA1C 471


REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION
set REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION
setSize 41
pANOVA 0.0837
s.dist 0.16
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
CTSZ 479
TUBA1C 471
B4GALT1 470
MLEC 462
ACTR1A 457
ARF4 444
UGGT1 434
ST6GALNAC1 424
ASGR2 416
MAN2A1 386
SPTB 384
SPTA1 368
PRKCSH 352
ANK1 331
ST6GAL1 324
RPS27A 304
GANAB 269
TUBB4B 230
TFG 214
SERPINA1 156

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CTSZ 479
TUBA1C 471
B4GALT1 470
MLEC 462
ACTR1A 457
ARF4 444
UGGT1 434
ST6GALNAC1 424
ASGR2 416
MAN2A1 386
SPTB 384
SPTA1 368
PRKCSH 352
ANK1 331
ST6GAL1 324
RPS27A 304
GANAB 269
TUBB4B 230
TFG 214
SERPINA1 156
MAN1A1 132
CTSC 73
CALR 62
LMAN2 58
TUBB1 22
RAB1B 14
PDIA3 -21
TUBA4A -57
DYNC1H1 -68
FUCA1 -69
VCP -82
F8 -142
TMED7 -174
F5 -223
HK1 -246
UMOD -278
ARF3 -282
RAB1A -283
CANX -363
TUBA8 -366
CAPZA1 -391


REACTOME_HSF1_ACTIVATION
set REACTOME_HSF1_ACTIVATION
setSize 7
pANOVA 0.0847
s.dist -0.378
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
EEF1A1 -277
HSP90AB1 -272
HSPB1 -168
HSP90AA1 -126
VCP -82
HSPA1A -55
YWHAE 112

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EEF1A1 -277
HSP90AB1 -272
HSPB1 -168
HSP90AA1 -126
VCP -82
HSPA1A -55
YWHAE 112


REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION
set REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION
setSize 50
pANOVA 0.0864
s.dist -0.144
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPD1 -397
IHH -378
BID -373
PRDX5 -364
PSMB7 -361
NOTCH1 -359
GP1BA -353
PSMB3 -334
PRDX1 -332
YWHAG -324
PIP4K2A -317
MYL9 -280
SRC -275
PF4 -266
GSR -261
PSMB2 -255
NOTCH2 -233
TGFB1 -226
EGFR -225
PSMA6 -205

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPD1 -397
IHH -378
BID -373
PRDX5 -364
PSMB7 -361
NOTCH1 -359
GP1BA -353
PSMB3 -334
PRDX1 -332
YWHAG -324
PIP4K2A -317
MYL9 -280
SRC -275
PF4 -266
GSR -261
PSMB2 -255
NOTCH2 -233
TGFB1 -226
EGFR -225
PSMA6 -205
THBS1 -200
CALM1 -171
PSMA1 -141
NOTCH3 -94
IGFBP3 -66
ITGA2B -52
G6PD -30
YWHAZ 3
MET 56
YWHAB 60
TXN 75
APOE 83
KIT 104
PSMA5 108
YWHAE 112
PSMA7 125
PSMA4 167
SERPINE1 221
RPS27A 304
LGALS3 320
SOD2 337
PRDX2 355
PSMD2 380
YWHAH 429
CCN2 449
CAT 453
GPI 468
PSMD3 480
CSF1R 484
MAPK1 497


REACTOME_ANTIGEN_PROCESSING_UB_ATP_INDEPENDENT_PROTEASOMAL_DEGRADATION
set REACTOME_ANTIGEN_PROCESSING_UB_ATP_INDEPENDENT_PROTEASOMAL_DEGRADATION
setSize 8
pANOVA 0.0866
s.dist -0.352
p.adjustANOVA 0.883


Top enriched genes
Top 20 genes
GeneID Gene Rank
PSMB7 -361
PSMB3 -334
PSMB2 -255
PSMA6 -205
PSMA1 -141
PSMA5 108
PSMA7 125
PSMA4 167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB7 -361
PSMB3 -334
PSMB2 -255
PSMA6 -205
PSMA1 -141
PSMA5 108
PSMA7 125
PSMA4 167


Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}
## Can't plot upregulated sets. Fewer than 5 found.
## Can't plot downregulated sets. Fewer than 5 found.
## No significant upregulated sets to show.
## No significant upregulated sets to show.
## [[1]]
## NULL

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.6.0 (2026-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] gtools_3.9.5           beeswarm_0.4.0         eulerr_7.1.0          
##  [4] msigdbr_26.1.0         mitch_1.24.0           knitr_1.51            
##  [7] ReactomePA_1.56.0      umap_0.2.10.0          org.Hs.eg.db_3.23.1   
## [10] AnnotationDbi_1.74.0   IRanges_2.46.0         S4Vectors_0.50.1      
## [13] Biobase_2.72.0         BiocGenerics_0.58.1    generics_0.1.4        
## [16] clusterProfiler_4.20.0 pheatmap_1.0.13        limma_3.68.2          
## [19] janitor_2.2.1          lubridate_1.9.5        forcats_1.0.1         
## [22] stringr_1.6.0          purrr_1.2.2            readr_2.2.0           
## [25] tidyr_1.3.2            tibble_3.3.1           ggplot2_4.0.3         
## [28] tidyverse_2.0.0        dplyr_1.2.1            BiocManager_1.30.27   
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.6.0           later_1.4.8             bitops_1.0-9           
##   [4] ggplotify_0.1.3         polyclip_1.10-7         enrichit_0.1.4         
##   [7] graph_1.90.0            lifecycle_1.0.5         httr2_1.2.2            
##  [10] vroom_1.7.1             processx_3.9.0          lattice_0.22-9         
##  [13] MASS_7.3-65             magrittr_2.0.5          sass_0.4.10            
##  [16] rmarkdown_2.31          jquerylib_0.1.4         yaml_2.3.12            
##  [19] httpuv_1.6.17           otel_0.2.0              ggtangle_0.1.2         
##  [22] askpass_1.2.1           reticulate_1.46.0       DBI_1.3.0              
##  [25] RColorBrewer_1.1-3      ggraph_2.2.2            yulab.utils_0.2.4      
##  [28] tweenr_2.0.3            rappdirs_0.3.4          aisdk_1.1.0            
##  [31] gdtools_0.5.0           enrichplot_1.32.0       ggrepel_0.9.8          
##  [34] tidytree_0.4.7          reactome.db_1.96.0      RSpectra_0.16-2        
##  [37] svglite_2.2.2           DOSE_4.6.0              xml2_1.5.2             
##  [40] ggforce_0.5.0           tidyselect_1.2.1        aplot_0.2.9            
##  [43] farver_2.1.2            viridis_0.6.5           Seqinfo_1.2.0          
##  [46] jsonlite_2.0.0          tidygraph_1.3.1         systemfonts_1.3.2      
##  [49] polylabelr_1.0.0        tools_4.6.0             ggnewscale_0.5.2       
##  [52] treeio_1.36.1           Rcpp_1.1.1-1.1          glue_1.8.1             
##  [55] gridExtra_2.3           xfun_0.57               qvalue_2.44.0          
##  [58] withr_3.0.2             fastmap_1.2.0           GGally_2.4.0           
##  [61] openssl_2.4.1           caTools_1.18.3          callr_3.7.6            
##  [64] digest_0.6.39           timechange_0.4.0        R6_2.6.1               
##  [67] mime_0.13               gridGraphics_0.5-1      textshaping_1.0.5      
##  [70] GO.db_3.23.1            dichromat_2.0-0.1       RSQLite_3.52.0         
##  [73] utf8_1.2.6              fontLiberation_0.1.0    graphlayouts_1.2.3     
##  [76] httr_1.4.8              htmlwidgets_1.6.4       scatterpie_0.2.6       
##  [79] ggstats_0.13.0          graphite_1.58.0         pkgconfig_2.0.3        
##  [82] gtable_0.3.6            blob_1.3.0              S7_0.2.2               
##  [85] XVector_0.52.0          htmltools_0.5.9         fontBitstreamVera_0.1.1
##  [88] echarts4r_0.5.0         scales_1.4.0            kableExtra_1.4.0       
##  [91] png_0.1-9               snakecase_0.11.1        ggfun_0.2.0            
##  [94] rstudioapi_0.18.0       tzdb_0.5.0              reshape2_1.4.5         
##  [97] curl_7.1.0              coda_0.19-4.1           statnet.common_4.13.0  
## [100] nlme_3.1-169            cachem_1.1.0            KernSmooth_2.23-26     
## [103] parallel_4.6.0          pillar_1.11.1           grid_4.6.0             
## [106] vctrs_0.7.3             gplots_3.3.0            promises_1.5.0         
## [109] tidydr_0.0.6            xtable_1.8-8            cluster_2.1.8.2        
## [112] evaluate_1.0.5          cli_3.6.6               compiler_4.6.0         
## [115] rlang_1.2.0             crayon_1.5.3            labeling_0.4.3         
## [118] ps_1.9.3                plyr_1.8.9              fs_2.1.0               
## [121] ggiraph_0.9.6           stringi_1.8.7           network_1.20.0         
## [124] viridisLite_0.4.3       babelgene_22.9          assertthat_0.2.1       
## [127] Biostrings_2.80.0       lazyeval_0.2.3          GOSemSim_2.38.0        
## [130] fontquiver_0.2.1        Matrix_1.7-5            hms_1.1.4              
## [133] patchwork_1.3.2         bit64_4.8.0             KEGGREST_1.52.0        
## [136] statmod_1.5.2           shiny_1.13.0            igraph_2.3.1           
## [139] memoise_2.0.1           bslib_0.11.0            ggtree_4.2.0           
## [142] bit_4.6.0               ape_5.8-1               gson_0.1.0

END of report