date generated: 2026-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
INF2 -4.987563
MAPK1 4.340409
ITM2B -3.288005
VPS29 -3.186019
ARRB1 3.172493
CDHR5 3.055350

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2830
num_genes_in_profile 904
duplicated_genes_present 0
num_profile_genes_in_sets 756
num_profile_genes_not_in_sets 148

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2830
num_genesets_excluded 2455
num_genesets_included 375

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Metabolism of lipids 30 0.00166 -0.3370 0.488
Peptide hormone metabolism 15 0.00394 0.4330 0.488
Formation of the cornified envelope 28 0.00414 0.3180 0.488
Keratinization 28 0.00414 0.3180 0.488
Platelet Adhesion to exposed collagen 10 0.00456 -0.5200 0.488
Syndecan interactions 10 0.00535 -0.5110 0.488
Diseases associated with O-glycosylation of proteins 9 0.00569 -0.5340 0.488
Non-integrin membrane-ECM interactions 19 0.00649 -0.3640 0.488
Neutrophil degranulation 152 0.00733 0.1380 0.490
Mitochondrial protein degradation 6 0.00918 -0.6160 0.553
EPHA-mediated growth cone collapse 7 0.01100 -0.5570 0.603
Cellular responses to stimuli 86 0.01230 -0.1640 0.616
Innate Immune System 277 0.01710 0.0993 0.747
Diseases of carbohydrate metabolism 6 0.01850 0.5570 0.747
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 5 0.02000 -0.6020 0.747
RHOBTB GTPase Cycle 8 0.02050 -0.4750 0.747
Signaling by Rho GTPases 70 0.02450 -0.1620 0.747
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 70 0.02450 -0.1620 0.747
Muscle contraction 16 0.02700 -0.3220 0.747
EPH-Ephrin signaling 20 0.02760 -0.2880 0.747
Scavenging by Class B Receptors 7 0.02840 -0.4800 0.747
Lysosome Vesicle Biogenesis 6 0.03010 0.5130 0.747
Folding of actin by CCT/TriC 6 0.03030 -0.5120 0.747
Association of TriC/CCT with target proteins during biosynthesis 6 0.03260 -0.5060 0.747
Sensory processing of sound 5 0.03290 -0.5520 0.747
Phospholipid metabolism 5 0.03460 -0.5470 0.747
Mitochondrial biogenesis 6 0.03560 -0.4970 0.747
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 10 0.03580 -0.3850 0.747
MET activates PTK2 signaling 8 0.03930 -0.4230 0.747
Signal Transduction 187 0.03950 -0.0976 0.747
VEGFA-VEGFR2 Pathway 10 0.03970 -0.3780 0.747
Fatty acid metabolism 11 0.03980 -0.3600 0.747
RHOBTB2 GTPase cycle 7 0.04180 -0.4460 0.747
Cellular responses to stress 68 0.04220 -0.1480 0.747
Immune System 337 0.04480 0.0797 0.757
Cell-extracellular matrix interactions 9 0.04530 -0.3870 0.757
EPHB-mediated forward signaling 12 0.04650 -0.3340 0.757
Complement cascade 91 0.05570 0.1220 0.876
Smooth Muscle Contraction 12 0.05840 -0.3180 0.876
Cell surface interactions at the vascular wall 75 0.06590 -0.1280 0.876
RHO GTPase cycle 38 0.06660 -0.1760 0.876
ECM proteoglycans 23 0.06740 -0.2230 0.876
RHOH GTPase cycle 8 0.06770 -0.3750 0.876
Response of endothelial cells to shear stress 16 0.07070 -0.2630 0.876
Metabolism of Angiotensinogen to Angiotensins 7 0.07230 0.3940 0.876
RHO GTPases activate PAKs 7 0.07560 -0.3890 0.876
Interaction between L1 and Ankyrins 5 0.07620 0.4590 0.876
Signaling by VEGF 13 0.07720 -0.2850 0.876
Asparagine N-linked glycosylation 41 0.07990 0.1620 0.876
Lectin pathway of complement activation 8 0.08000 0.3590 0.876


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Metabolism of lipids 30 0.00166 -0.337000 0.488
Peptide hormone metabolism 15 0.00394 0.433000 0.488
Formation of the cornified envelope 28 0.00414 0.318000 0.488
Keratinization 28 0.00414 0.318000 0.488
Platelet Adhesion to exposed collagen 10 0.00456 -0.520000 0.488
Syndecan interactions 10 0.00535 -0.511000 0.488
Diseases associated with O-glycosylation of proteins 9 0.00569 -0.534000 0.488
Non-integrin membrane-ECM interactions 19 0.00649 -0.364000 0.488
Neutrophil degranulation 152 0.00733 0.138000 0.490
Mitochondrial protein degradation 6 0.00918 -0.616000 0.553
EPHA-mediated growth cone collapse 7 0.01100 -0.557000 0.603
Cellular responses to stimuli 86 0.01230 -0.164000 0.616
Innate Immune System 277 0.01710 0.099300 0.747
Diseases of carbohydrate metabolism 6 0.01850 0.557000 0.747
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 5 0.02000 -0.602000 0.747
RHOBTB GTPase Cycle 8 0.02050 -0.475000 0.747
Signaling by Rho GTPases 70 0.02450 -0.162000 0.747
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 70 0.02450 -0.162000 0.747
Muscle contraction 16 0.02700 -0.322000 0.747
EPH-Ephrin signaling 20 0.02760 -0.288000 0.747
Scavenging by Class B Receptors 7 0.02840 -0.480000 0.747
Lysosome Vesicle Biogenesis 6 0.03010 0.513000 0.747
Folding of actin by CCT/TriC 6 0.03030 -0.512000 0.747
Association of TriC/CCT with target proteins during biosynthesis 6 0.03260 -0.506000 0.747
Sensory processing of sound 5 0.03290 -0.552000 0.747
Phospholipid metabolism 5 0.03460 -0.547000 0.747
Mitochondrial biogenesis 6 0.03560 -0.497000 0.747
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 10 0.03580 -0.385000 0.747
MET activates PTK2 signaling 8 0.03930 -0.423000 0.747
Signal Transduction 187 0.03950 -0.097600 0.747
VEGFA-VEGFR2 Pathway 10 0.03970 -0.378000 0.747
Fatty acid metabolism 11 0.03980 -0.360000 0.747
RHOBTB2 GTPase cycle 7 0.04180 -0.446000 0.747
Cellular responses to stress 68 0.04220 -0.148000 0.747
Immune System 337 0.04480 0.079700 0.757
Cell-extracellular matrix interactions 9 0.04530 -0.387000 0.757
EPHB-mediated forward signaling 12 0.04650 -0.334000 0.757
Complement cascade 91 0.05570 0.122000 0.876
Smooth Muscle Contraction 12 0.05840 -0.318000 0.876
Cell surface interactions at the vascular wall 75 0.06590 -0.128000 0.876
RHO GTPase cycle 38 0.06660 -0.176000 0.876
ECM proteoglycans 23 0.06740 -0.223000 0.876
RHOH GTPase cycle 8 0.06770 -0.375000 0.876
Response of endothelial cells to shear stress 16 0.07070 -0.263000 0.876
Metabolism of Angiotensinogen to Angiotensins 7 0.07230 0.394000 0.876
RHO GTPases activate PAKs 7 0.07560 -0.389000 0.876
Interaction between L1 and Ankyrins 5 0.07620 0.459000 0.876
Signaling by VEGF 13 0.07720 -0.285000 0.876
Asparagine N-linked glycosylation 41 0.07990 0.162000 0.876
Lectin pathway of complement activation 8 0.08000 0.359000 0.876
Apoptotic cleavage of cell adhesion proteins 5 0.08020 0.453000 0.876
Infectious disease 171 0.08140 -0.085500 0.876
Disease 248 0.08280 -0.074700 0.876
Organelle biogenesis and maintenance 24 0.08400 -0.207000 0.876
Generic Transcription Pathway 50 0.08460 -0.145000 0.876
RNA Polymerase II Transcription 50 0.08460 -0.145000 0.876
Antigen processing: Ub, ATP-independent proteasomal degradation 8 0.08480 -0.354000 0.876
Signaling by NOTCH3 5 0.08600 -0.445000 0.876
Formation of Fibrin Clot (Clotting Cascade) 32 0.08720 0.178000 0.876
HSF1 activation 7 0.08730 -0.375000 0.876
Cell junction organization 46 0.08910 -0.149000 0.880
Signaling by NOTCH4 16 0.09450 -0.244000 0.913
Metabolism of steroids 5 0.09690 -0.430000 0.913
GP1b-IX-V activation signalling 8 0.10500 -0.333000 0.913
Glutathione conjugation 5 0.10700 -0.417000 0.913
Translation of Structural Proteins 9694635 6 0.10800 0.380000 0.913
MyD88 cascade initiated on plasma membrane 5 0.11600 0.407000 0.913
Toll Like Receptor 10 (TLR10) Cascade 5 0.11600 0.407000 0.913
Toll Like Receptor 3 (TLR3) Cascade 5 0.11600 0.407000 0.913
Toll Like Receptor 5 (TLR5) Cascade 5 0.11600 0.407000 0.913
O-linked glycosylation 9 0.11600 -0.304000 0.913
MyD88 dependent cascade initiated on endosome 6 0.11700 0.371000 0.913
MyD88-independent TLR4 cascade 6 0.11700 0.371000 0.913
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 6 0.11700 0.371000 0.913
TRIF (TICAM1)-mediated TLR4 signaling 6 0.11700 0.371000 0.913
Toll Like Receptor 7/8 (TLR7/8) Cascade 6 0.11700 0.371000 0.913
Toll Like Receptor 9 (TLR9) Cascade 6 0.11700 0.371000 0.913
Metal sequestration by antimicrobial proteins 5 0.12000 -0.403000 0.917
Gene expression (Transcription) 57 0.12000 -0.123000 0.917
Formation of the dystrophin-glycoprotein complex (DGC) 7 0.12500 -0.337000 0.939
Glycosaminoglycan metabolism 14 0.13100 0.235000 0.954
Transcriptional regulation by RUNX1 18 0.13100 -0.208000 0.954
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 11 0.13100 -0.264000 0.954
Intrinsic Pathway of Fibrin Clot Formation 22 0.13900 0.185000 0.975
TGF-beta receptor signaling activates SMADs 9 0.14400 -0.283000 0.975
LDL remodeling 5 0.14400 -0.378000 0.975
Plasma lipoprotein remodeling 17 0.14800 -0.205000 0.975
Defects of platelet adhesion to exposed collagen 6 0.15200 -0.339000 0.975
Platelet activation, signaling and aggregation 103 0.15200 -0.086700 0.975
Platelet homeostasis 6 0.15300 -0.338000 0.975
Semaphorin interactions 16 0.16100 -0.204000 0.975
Sensory Perception 20 0.16300 -0.182000 0.975
Formation of tubulin folding intermediates by CCT/TriC 10 0.16400 -0.256000 0.975
Attenuation phase 5 0.16500 -0.360000 0.975
HSF1-dependent transactivation 5 0.16500 -0.360000 0.975
Cellular responses to mechanical stimuli 18 0.16500 -0.191000 0.975
Uptake and actions of bacterial toxins 6 0.17100 -0.324000 0.975
C-type lectin receptors (CLRs) 17 0.17500 -0.192000 0.975
NCAM signaling for neurite out-growth 10 0.17500 0.249000 0.975
EPH-ephrin mediated repulsion of cells 7 0.18000 -0.294000 0.975
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 9 0.18700 0.256000 0.975
Maturation of spike protein 9694548 5 0.18900 0.341000 0.975
Arachidonate metabolism 9 0.18900 -0.254000 0.975
Diseases of signal transduction by growth factor receptors and second messengers 51 0.19300 -0.108000 0.975
MAP2K and MAPK activation 16 0.19400 0.189000 0.975
Signaling by high-kinase activity BRAF mutants 16 0.19400 0.189000 0.975
Cell-Cell communication 51 0.19700 -0.107000 0.975
Sema4D induced cell migration and growth-cone collapse 7 0.20400 -0.279000 0.975
Defective binding of VWF variant to GPIb:IX:V 5 0.20500 -0.329000 0.975
Enhanced binding of GP1BA variant to VWF multimer:collagen 5 0.20500 -0.329000 0.975
Viral Infection Pathways 122 0.20700 -0.071000 0.975
Regulation of Complement cascade 81 0.21100 0.084200 0.975
Transport to the Golgi and subsequent modification 28 0.21100 0.139000 0.975
Aerobic respiration and respiratory electron transport 13 0.22100 -0.198000 0.975
Keratan sulfate biosynthesis 6 0.22200 0.289000 0.975
Ion channel transport 5 0.22700 -0.313000 0.975
IRE1alpha activates chaperones 6 0.22800 -0.285000 0.975
Advanced glycosylation endproduct receptor signaling 6 0.22900 0.285000 0.975
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 7 0.23000 -0.263000 0.975
Axon guidance 71 0.23000 -0.085700 0.975
Nervous system development 72 0.23100 -0.085000 0.975
Respiratory Syncytial Virus Infection Pathway 9 0.23500 -0.230000 0.975
Unfolded Protein Response (UPR) 8 0.23500 -0.244000 0.975
Class I MHC mediated antigen processing & presentation 36 0.23500 -0.117000 0.975
Sema4D in semaphorin signaling 8 0.24100 -0.241000 0.975
XBP1(S) activates chaperone genes 5 0.24400 -0.302000 0.975
Signaling by ROBO receptors 17 0.24500 -0.165000 0.975
Nuclear events mediated by NFE2L2 21 0.24500 -0.148000 0.975
Diseases of glycosylation 16 0.24500 -0.169000 0.975
Translation of Structural Proteins 9683701 5 0.24600 0.301000 0.975
Basigin interactions 5 0.24800 -0.299000 0.975
Thrombin signalling through proteinase activated receptors (PARs) 7 0.25200 0.251000 0.975
Infection with Mycobacterium tuberculosis 9 0.25600 0.220000 0.975
Ficolins bind to repetitive carbohydrate structures on the target cell surface 5 0.26200 0.291000 0.975
Platelet degranulation 82 0.26400 -0.074800 0.975
Response to elevated platelet cytosolic Ca2+ 82 0.26400 -0.074800 0.975
RAB geranylgeranylation 9 0.26900 -0.214000 0.975
trans-Golgi Network Vesicle Budding 12 0.26900 0.186000 0.975
Dengue Virus Genome Translation and Replication 12 0.27100 -0.185000 0.975
Activation of Matrix Metalloproteinases 9 0.27100 0.213000 0.975
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 8 0.27600 -0.223000 0.975
Formation of paraxial mesoderm 11 0.27900 -0.190000 0.975
Somitogenesis 11 0.27900 -0.190000 0.975
Prefoldin mediated transfer of substrate to CCT/TriC 10 0.27900 -0.199000 0.975
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 12 0.28400 -0.180000 0.975
Calnexin/calreticulin cycle 7 0.28400 0.235000 0.975
Fcgamma receptor (FCGR) dependent phagocytosis 64 0.28800 -0.079700 0.975
DNA Repair 5 0.28800 -0.275000 0.975
Paradoxical activation of RAF signaling by kinase inactive BRAF 17 0.28900 0.150000 0.975
Signaling by RAS mutants 17 0.28900 0.150000 0.975
Signaling by moderate kinase activity BRAF mutants 17 0.28900 0.150000 0.975
Signaling downstream of RAS mutants 17 0.28900 0.150000 0.975
Laminin interactions 10 0.29000 -0.194000 0.975
Nucleotide salvage 5 0.29100 -0.274000 0.975
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 13 0.29800 -0.168000 0.975
Hemostasis 194 0.30300 -0.048200 0.975
FCGR3A-mediated phagocytosis 61 0.30400 -0.078800 0.975
Leishmania phagocytosis 61 0.30400 -0.078800 0.975
Parasite infection 61 0.30400 -0.078800 0.975
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 11 0.30600 0.179000 0.975
Toll Like Receptor 2 (TLR2) Cascade 11 0.30600 0.179000 0.975
Toll Like Receptor TLR1:TLR2 Cascade 11 0.30600 0.179000 0.975
Toll Like Receptor TLR6:TLR2 Cascade 11 0.30600 0.179000 0.975
Chaperonin-mediated protein folding 15 0.31400 -0.152000 0.975
Protein folding 15 0.31400 -0.152000 0.975
Late SARS-CoV-2 Infection Events 7 0.31500 0.221000 0.975
Degradation of the extracellular matrix 28 0.31900 0.111000 0.975
Maturation of DENV proteins 8 0.32000 -0.204000 0.975
Cell-cell junction organization 35 0.32100 -0.098900 0.975
GPER1 signaling 7 0.32200 -0.217000 0.975
Toll Like Receptor 4 (TLR4) Cascade 13 0.32400 0.159000 0.975
Transcriptional and post-translational regulation of MITF-M expression and activity 8 0.32500 0.202000 0.975
Developmental Cell Lineages 5 0.32600 -0.255000 0.975
Developmental Cell Lineages of the Exocrine Pancreas 5 0.32600 -0.255000 0.975
Developmental Lineage of Pancreatic Ductal Cells 5 0.32600 -0.255000 0.975
KEAP1-NFE2L2 pathway 23 0.32800 -0.119000 0.975
Cellular response to heat stress 12 0.33100 -0.163000 0.975
Drug ADME 11 0.33200 -0.170000 0.975
Adaptive Immune System 127 0.33200 -0.053600 0.975
Constitutive Signaling by Aberrant PI3K in Cancer 6 0.33400 -0.229000 0.975
PI3K/AKT Signaling in Cancer 6 0.33400 -0.229000 0.975
RHO GTPase Effectors 40 0.33500 -0.090200 0.975
Chylomicron assembly 8 0.33700 -0.197000 0.975
Adherens junctions interactions 34 0.33700 -0.097100 0.975
Common Pathway of Fibrin Clot Formation 17 0.33700 0.136000 0.975
Late endosomal microautophagy 5 0.33900 0.248000 0.975
Transcriptional Regulation by TP53 16 0.33900 -0.139000 0.975
Translation 17 0.34000 -0.135000 0.975
Diseases associated with glycosaminoglycan metabolism 6 0.34000 0.226000 0.975
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane 5 0.34200 0.246000 0.975
Leishmania infection 73 0.34700 -0.066400 0.975
Parasitic Infection Pathways 73 0.34700 -0.066400 0.975
Signaling by RAF1 mutants 16 0.35000 0.136000 0.975
MET promotes cell motility 10 0.35100 -0.171000 0.975
GRB2:SOS provides linkage to MAPK signaling for Integrins 11 0.35300 0.163000 0.975
ESR-mediated signaling 13 0.35300 -0.150000 0.975
Metabolism of carbohydrates and carbohydrate derivatives 42 0.35400 0.084600 0.975
Striated Muscle Contraction 5 0.35500 -0.240000 0.975
Metabolism 155 0.36000 -0.046700 0.975
Collagen degradation 10 0.36100 0.168000 0.975
Regulation of RUNX3 expression and activity 13 0.36400 -0.147000 0.975
ER-Phagosome pathway 24 0.36500 -0.108000 0.975
Gamma-carboxylation of protein precursors 7 0.36800 0.198000 0.975
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 7 0.36800 0.198000 0.975
Removal of aminoterminal propeptides from gamma-carboxylated proteins 7 0.36800 0.198000 0.975
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 7 0.36800 0.198000 0.975
Downstream signaling events of B Cell Receptor (BCR) 14 0.36900 -0.140000 0.975
Gastrulation 14 0.37200 -0.139000 0.975
RHOA GTPase cycle 12 0.37500 -0.149000 0.975
Regulation of CDH1 Function 20 0.37700 -0.115000 0.975
Dengue Virus Infection 33 0.37800 -0.090400 0.975
Extra-nuclear estrogen signaling 11 0.37800 -0.154000 0.975
Anti-inflammatory response favouring Leishmania parasite infection 58 0.37900 -0.069000 0.975
Leishmania parasite growth and survival 58 0.37900 -0.069000 0.975
ABC transporter disorders 13 0.38000 -0.142000 0.975
Activation of NMDA receptors and postsynaptic events 10 0.38000 0.161000 0.975
RAC3 GTPase cycle 8 0.38200 -0.179000 0.975
Interleukin-12 family signaling 16 0.38700 -0.126000 0.975
Regulation of T cell activation by CD28 family 17 0.38800 -0.122000 0.975
Cargo trafficking to the periciliary membrane 12 0.39100 -0.144000 0.975
Transcriptional regulation by RUNX3 15 0.39300 -0.129000 0.975
FCGR activation 50 0.39400 -0.071700 0.975
Host Interactions of HIV factors 16 0.39400 -0.124000 0.975
Signaling by WNT 18 0.39900 -0.116000 0.975
HCMV Early Events 8 0.40100 -0.172000 0.975
HCMV Infection 8 0.40100 -0.172000 0.975
Protein-protein interactions at synapses 7 0.40200 -0.184000 0.975
Signal regulatory protein family interactions 5 0.40300 0.217000 0.975
Golgi Associated Vesicle Biogenesis 9 0.40400 0.162000 0.975
Protein ubiquitination 5 0.40700 -0.215000 0.975
Oncogenic MAPK signaling 18 0.40900 0.114000 0.975
Signaling by BRAF and RAF1 fusions 18 0.40900 0.114000 0.975
Co-inhibition by PD-1 13 0.41600 -0.131000 0.975
Regulation of PD-L1(CD274) Post-translational modification 13 0.41600 -0.131000 0.975
Regulation of PD-L1(CD274) expression 13 0.41600 -0.131000 0.975
Phase II - Conjugation of compounds 7 0.41600 -0.179000 0.975
Cellular response to chemical stress 37 0.42300 -0.077700 0.975
Dissolution of Fibrin Clot 6 0.42500 -0.189000 0.975
FCGR3A-mediated IL10 synthesis 52 0.42600 -0.065700 0.975
G-protein mediated events 5 0.42800 0.205000 0.975
Translocation of SLC2A4 (GLUT4) to the plasma membrane 18 0.42800 -0.109000 0.975
MITF-M-regulated melanocyte development 15 0.43200 0.118000 0.975
Pre-NOTCH Processing in Golgi 6 0.43200 -0.186000 0.975
HIV Infection 17 0.43300 -0.111000 0.975
RHO GTPases activate CIT 5 0.44200 -0.199000 0.975
Cilium Assembly 18 0.44300 -0.106000 0.975
Interleukin-4 and Interleukin-13 signaling 22 0.44400 -0.095400 0.975
Dengue Virus-Host Interactions 18 0.44500 -0.105000 0.975
Scavenging by Class A Receptors 11 0.44600 -0.134000 0.975
Signaling by EGFR 5 0.44700 -0.197000 0.975
Kinesins 6 0.44700 0.180000 0.975
Endosomal/Vacuolar pathway 5 0.45100 -0.196000 0.975
Listeria monocytogenes entry into host cells 5 0.45200 0.195000 0.975
Signaling by FGFR 5 0.45600 0.193000 0.975
Signaling by FGFR2 5 0.45600 0.193000 0.975
CLEC7A (Dectin-1) signaling 15 0.45900 -0.112000 0.975
Keratan sulfate/keratin metabolism 7 0.45900 0.162000 0.975
FLT3 Signaling 5 0.46000 0.192000 0.975
UCH proteinases 13 0.46200 -0.119000 0.975
Signaling by MET 13 0.46600 -0.118000 0.975
Metabolism of vitamins and cofactors 27 0.47000 -0.081600 0.975
Degradation of CDH1 17 0.47100 -0.102000 0.975
Potential therapeutics for SARS 46 0.47300 -0.062800 0.975
Regulation of actin dynamics for phagocytic cup formation 62 0.47700 -0.054100 0.975
Signaling by NOTCH 24 0.47900 -0.084800 0.975
SPOP-mediated proteasomal degradation of PD-L1(CD274) 12 0.48100 -0.118000 0.975
Regulation of expression of SLITs and ROBOs 12 0.48200 -0.118000 0.975
Signaling by the B Cell Receptor (BCR) 54 0.48200 -0.057000 0.975
Developmental Biology 121 0.48700 0.039300 0.975
RAF/MAP kinase cascade 37 0.48800 0.067400 0.975
Metabolism of water-soluble vitamins and cofactors 10 0.48800 -0.128000 0.975
Rab regulation of trafficking 12 0.48800 -0.116000 0.975
Signaling by Receptor Tyrosine Kinases 49 0.49100 -0.058500 0.975
Signaling by Hedgehog 21 0.49700 0.086800 0.975
Signaling by NTRK1 (TRKA) 6 0.49700 0.161000 0.975
Dengue virus activates/modulates innate and adaptive immune responses 12 0.50500 -0.112000 0.975
MAPK1/MAPK3 signaling 38 0.50700 0.063500 0.975
Transport of small molecules 63 0.50800 -0.050000 0.975
Transmission across Chemical Synapses 17 0.51100 0.093000 0.975
Collagen biosynthesis and modifying enzymes 8 0.51300 0.134000 0.975
PIP3 activates AKT signaling 20 0.51500 -0.085100 0.975
ABC-family proteins mediated transport 14 0.51600 -0.101000 0.975
Signaling by TGF-beta Receptor Complex 12 0.51800 -0.109000 0.975
HDL remodeling 8 0.52000 -0.132000 0.975
Mitotic G1 phase and G1/S transition 12 0.52000 -0.108000 0.975
Defective F9 activation 6 0.52000 -0.152000 0.975
Defective factor VIII causes hemophilia A 5 0.52200 0.166000 0.975
Metabolism of polyamines 10 0.52500 -0.117000 0.975
Regulation of ornithine decarboxylase (ODC) 10 0.52500 -0.117000 0.975
Negative regulation of the PI3K/AKT network 9 0.53000 -0.122000 0.975
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 9 0.53000 -0.122000 0.975
G alpha (q) signalling events 14 0.53100 0.097600 0.975
Platelet Aggregation (Plug Formation) 18 0.53200 -0.086000 0.975
Regulation of mRNA stability by proteins that bind AU-rich elements 17 0.54100 -0.086500 0.975
Metabolism of amino acids and derivatives 20 0.54200 -0.079600 0.975
The role of GTSE1 in G2/M progression after G2 checkpoint 18 0.54400 -0.083500 0.975
AUF1 (hnRNP D0) binds and destabilizes mRNA 14 0.54600 -0.094100 0.975
Disorders of transmembrane transporters 18 0.54800 -0.082800 0.975
Ub-specific processing proteases 13 0.55300 0.095700 0.975
Signaling by GPCR 32 0.55500 -0.061400 0.975
Cytokine Signaling in Immune system 77 0.55600 -0.040600 0.975
Elastic fibre formation 10 0.55800 -0.108000 0.975
Molecules associated with elastic fibres 10 0.55800 -0.108000 0.975
Cargo recognition for clathrin-mediated endocytosis 10 0.55900 0.107000 0.975
Defective Intrinsic Pathway for Apoptosis 7 0.56000 0.128000 0.975
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 7 0.56000 0.128000 0.975
Diseases of programmed cell death 7 0.56000 0.128000 0.975
Neurodegenerative Diseases 7 0.56000 0.128000 0.975
p130Cas linkage to MAPK signaling for integrins 10 0.56100 0.107000 0.975
Influenza Infection 8 0.56400 -0.119000 0.975
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 7 0.56400 0.127000 0.975
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 14 0.56600 -0.089400 0.975
Apoptotic cleavage of cellular proteins 9 0.56700 0.111000 0.975
Initial triggering of complement 67 0.56900 0.041900 0.975
Activation of BAD and translocation to mitochondria 6 0.56900 -0.135000 0.975
Activation of BH3-only proteins 6 0.56900 -0.135000 0.975
Pyruvate metabolism 6 0.56900 0.135000 0.975
Metabolism of fat-soluble vitamins 13 0.57200 -0.091300 0.975
Retinoid metabolism and transport 13 0.57200 -0.091300 0.975
Intracellular signaling by second messengers 22 0.57600 -0.069800 0.975
ER to Golgi Anterograde Transport 23 0.58000 0.067600 0.975
Opioid Signalling 8 0.58000 0.114000 0.975
Antimicrobial peptides 14 0.58100 -0.086000 0.975
Interferon gamma signaling 9 0.58100 0.107000 0.975
Detoxification of Reactive Oxygen Species 15 0.58100 -0.083000 0.975
RHO GTPases Activate ROCKs 7 0.58300 -0.121000 0.975
Sema3A PAK dependent Axon repulsion 5 0.58300 -0.142000 0.975
MAPK family signaling cascades 40 0.58700 0.050800 0.975
GPCR downstream signalling 30 0.58800 -0.058200 0.975
EML4 and NUDC in mitotic spindle formation 7 0.59500 0.117000 0.975
Resolution of Sister Chromatid Cohesion 7 0.59500 0.117000 0.975
Terminal pathway of complement 8 0.59600 0.109000 0.975
Post-translational modification: synthesis of GPI-anchored proteins 9 0.60500 -0.100000 0.975
DAP12 interactions 6 0.60700 -0.122000 0.975
Clathrin-mediated endocytosis 19 0.60800 -0.068800 0.975
G2/M Transition 24 0.61000 -0.061000 0.975
Mitotic G2-G2/M phases 24 0.61000 -0.061000 0.975
Regulation of CDH1 Expression and Function 26 0.61200 -0.058300 0.975
Regulation of Expression and Function of Type I Classical Cadherins 26 0.61200 -0.058300 0.975
Regulation of Homotypic Cell-Cell Adhesion 26 0.61200 -0.058300 0.975
FOXO-mediated transcription 6 0.61500 0.119000 0.975
Hedgehog ‘off’ state 16 0.61700 0.072900 0.975
Hh mutants abrogate ligand secretion 14 0.61700 -0.077800 0.975
Signaling by CSF1 (M-CSF) in myeloid cells 5 0.61900 0.129000 0.975
Interleukin-12 signaling 15 0.61900 -0.074800 0.975
Chylomicron remodeling 9 0.62100 -0.095700 0.975
Binding and Uptake of Ligands by Scavenger Receptors 74 0.62700 -0.034100 0.975
FCERI mediated NF-kB activation 57 0.62900 -0.038200 0.975
SARS-CoV Infections 73 0.63100 -0.033900 0.975
RHO GTPases activate PKNs 10 0.63200 -0.087900 0.975
Signal amplification 5 0.63500 -0.123000 0.975
Anchoring of the basal body to the plasma membrane 10 0.63700 -0.086800 0.975
Extracellular matrix organization 66 0.63800 -0.034800 0.975
Neurotransmitter receptors and postsynaptic signal transmission 13 0.63800 0.075900 0.975
SARS-CoV-1-host interactions 11 0.63900 -0.082400 0.975
Mitotic Prometaphase 12 0.64400 0.077500 0.975
Antigen processing: Ubiquitination & Proteasome degradation 16 0.64500 -0.067100 0.975
Antigen processing-Cross presentation 27 0.64500 -0.052000 0.975
MAPK6/MAPK4 signaling 13 0.64600 -0.074200 0.975
Role of phospholipids in phagocytosis 48 0.64900 -0.039000 0.975
Mitochondrial unfolded protein response (UPRmt) 5 0.65700 0.115000 0.975
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 12 0.66400 -0.073100 0.975
Defective CFTR causes cystic fibrosis 12 0.66400 -0.073100 0.975
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 12 0.66400 -0.073100 0.975
Ribosome-associated quality control 12 0.66400 -0.073100 0.975
RHO GTPases Activate WASPs and WAVEs 10 0.66800 -0.079000 0.975
Metabolism of nucleotides 9 0.67000 -0.082600 0.975
Hedgehog ligand biogenesis 15 0.67100 -0.064000 0.975
Beta-catenin independent WNT signaling 16 0.67500 -0.061100 0.975
Regulation of insulin secretion 6 0.67900 0.098000 0.975
Metabolism of RNA 23 0.67900 -0.050500 0.975
Amyloid fiber formation 18 0.68600 0.055700 0.975
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 41 0.69100 -0.036800 0.975
Creation of C4 and C2 activators 60 0.69100 0.030700 0.975
TP53 Regulates Metabolic Genes 12 0.69300 -0.066300 0.975
TCR signaling 16 0.69400 0.057400 0.975
Integrin signaling 13 0.69800 0.062600 0.975
Assembly of active LPL and LIPC lipase complexes 5 0.69900 0.100000 0.975
Fc epsilon receptor (FCERI) signaling 62 0.69900 -0.029400 0.975
Regulation of TLR by endogenous ligand 8 0.70100 -0.079000 0.975
Intra-Golgi and retrograde Golgi-to-ER traffic 19 0.70400 0.051000 0.975
Biological oxidations 19 0.70600 -0.050500 0.975
Post NMDA receptor activation events 9 0.70800 0.072600 0.975
COPI-mediated anterograde transport 16 0.71200 0.053900 0.975
Visual phototransduction 15 0.71200 -0.055600 0.975
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 6 0.72000 0.085000 0.975
Plasma lipoprotein assembly, remodeling, and clearance 24 0.72200 -0.042600 0.975
Gap junction trafficking and regulation 8 0.72800 -0.071400 0.975
RAB GEFs exchange GTP for GDP on RABs 11 0.72800 -0.061000 0.975
Proteasome assembly 12 0.72900 -0.058100 0.975
PCP/CE pathway 13 0.72900 -0.055900 0.975
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 59 0.73000 -0.026900 0.975
Neddylation 14 0.73300 -0.053100 0.975
Negative regulation of NOTCH4 signaling 12 0.73400 -0.057000 0.975
TCF dependent signaling in response to WNT 12 0.73400 -0.057000 0.975
Deubiquitination 17 0.73500 -0.047900 0.975
Protein localization 9 0.73800 -0.064700 0.975
Regulated Necrosis 5 0.73900 0.086500 0.975
RND1 GTPase cycle 5 0.74000 -0.086100 0.975
RHOC GTPase cycle 9 0.74100 0.063900 0.975
NR1H2 and NR1H3-mediated signaling 8 0.74800 0.065800 0.975
G alpha (s) signalling events 8 0.75400 -0.064500 0.975
Factors involved in megakaryocyte development and platelet production 13 0.75500 0.050500 0.975
Defective factor IX causes hemophilia B 8 0.75700 -0.063600 0.975
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 61 0.75700 0.023700 0.975
MITF-M-dependent gene expression 8 0.76000 0.062800 0.975
APC/C-mediated degradation of cell cycle proteins 11 0.76100 -0.053400 0.975
APC/C:Cdc20 mediated degradation of Securin 11 0.76100 -0.053400 0.975
APC/C:Cdc20 mediated degradation of mitotic proteins 11 0.76100 -0.053400 0.975
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 11 0.76100 -0.053400 0.975
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 11 0.76100 -0.053400 0.975
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 11 0.76100 -0.053400 0.975
Activation of NF-kappaB in B cells 11 0.76100 -0.053400 0.975
Assembly of the pre-replicative complex 11 0.76100 -0.053400 0.975
Asymmetric localization of PCP proteins 11 0.76100 -0.053400 0.975
Autodegradation of Cdh1 by Cdh1:APC/C 11 0.76100 -0.053400 0.975
Autodegradation of the E3 ubiquitin ligase COP1 11 0.76100 -0.053400 0.975
CDK-mediated phosphorylation and removal of Cdc6 11 0.76100 -0.053400 0.975
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 11 0.76100 -0.053400 0.975
Cellular response to hypoxia 11 0.76100 -0.053400 0.975
Cyclin A:Cdk2-associated events at S phase entry 11 0.76100 -0.053400 0.975
Cyclin E associated events during G1/S transition 11 0.76100 -0.053400 0.975
DNA Replication 11 0.76100 -0.053400 0.975
DNA Replication Pre-Initiation 11 0.76100 -0.053400 0.975
Dectin-1 mediated noncanonical NF-kB signaling 11 0.76100 -0.053400 0.975
Degradation of AXIN 11 0.76100 -0.053400 0.975
Degradation of CRY and PER proteins 11 0.76100 -0.053400 0.975
Degradation of DVL 11 0.76100 -0.053400 0.975
Degradation of GLI1 by the proteasome 11 0.76100 -0.053400 0.975
Degradation of GLI2 by the proteasome 11 0.76100 -0.053400 0.975
Degradation of beta-catenin by the destruction complex 11 0.76100 -0.053400 0.975
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 11 0.76100 -0.053400 0.975
G1/S DNA Damage Checkpoints 11 0.76100 -0.053400 0.975
G1/S Transition 11 0.76100 -0.053400 0.975
GLI3 is processed to GLI3R by the proteasome 11 0.76100 -0.053400 0.975
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 11 0.76100 -0.053400 0.975
GSK3B-mediated proteasomal degradation of PD-L1(CD274) 11 0.76100 -0.053400 0.975
NIK–>noncanonical NF-kB signaling 11 0.76100 -0.053400 0.975
Orc1 removal from chromatin 11 0.76100 -0.053400 0.975
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 11 0.76100 -0.053400 0.975
RUNX1 regulates transcription of genes involved in differentiation of HSCs 11 0.76100 -0.053400 0.975
Regulation of APC/C activators between G1/S and early anaphase 11 0.76100 -0.053400 0.975
Regulation of Apoptosis 11 0.76100 -0.053400 0.975
Regulation of PTEN stability and activity 11 0.76100 -0.053400 0.975
Regulation of RAS by GAPs 11 0.76100 -0.053400 0.975
Regulation of RUNX2 expression and activity 11 0.76100 -0.053400 0.975
Regulation of activated PAK-2p34 by proteasome mediated degradation 11 0.76100 -0.053400 0.975
Regulation of mitotic cell cycle 11 0.76100 -0.053400 0.975
S Phase 11 0.76100 -0.053400 0.975
SCF(Skp2)-mediated degradation of p27/p21 11 0.76100 -0.053400 0.975
SCF-beta-TrCP mediated degradation of Emi1 11 0.76100 -0.053400 0.975
Stabilization of p53 11 0.76100 -0.053400 0.975
Switching of origins to a post-replicative state 11 0.76100 -0.053400 0.975
Synthesis of DNA 11 0.76100 -0.053400 0.975
TNFR2 non-canonical NF-kB pathway 11 0.76100 -0.053400 0.975
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 11 0.76100 -0.053400 0.975
Ubiquitin-dependent degradation of Cyclin D 11 0.76100 -0.053400 0.975
Vif-mediated degradation of APOBEC3G 11 0.76100 -0.053400 0.975
Vpu mediated degradation of CD4 11 0.76100 -0.053400 0.975
p53-Dependent G1 DNA Damage Response 11 0.76100 -0.053400 0.975
p53-Dependent G1/S DNA damage checkpoint 11 0.76100 -0.053400 0.975
p53-Independent G1/S DNA Damage Checkpoint 11 0.76100 -0.053400 0.975
FCERI mediated MAPK activation 47 0.76100 0.026400 0.975
SARS-CoV-2 activates/modulates innate and adaptive immune responses 11 0.76300 -0.052800 0.975
G alpha (i) signalling events 19 0.76300 0.040400 0.975
SLC-mediated transmembrane transport 6 0.76300 0.071300 0.975
Toll-like Receptor Cascades 17 0.76400 0.042500 0.975
Signaling by ERBB4 6 0.76800 -0.069800 0.975
Attachment of bacteria to epithelial cells 5 0.77100 -0.075400 0.975
Biofilm formation 5 0.77100 -0.075400 0.975
Nuclear Envelope (NE) Reassembly 6 0.77400 0.067900 0.975
RAC1 GTPase cycle 8 0.77400 -0.058900 0.975
Integration of energy metabolism 10 0.77600 -0.052300 0.975
Gluconeogenesis 9 0.77900 0.054300 0.975
Glycogen metabolism 6 0.78000 0.066100 0.975
Signaling by ALK fusions and activated point mutants 14 0.78100 -0.043300 0.975
Signaling by ALK in cancer 14 0.78100 -0.043300 0.975
Classical antibody-mediated complement activation 52 0.78100 -0.023000 0.975
SLC transporter disorders 5 0.78200 0.071900 0.975
Interferon Signaling 20 0.78200 0.036200 0.975
Transcriptional regulation by RUNX2 15 0.78200 -0.041600 0.975
RAC2 GTPase cycle 6 0.78300 -0.065300 0.975
Signaling by Interleukins 60 0.78400 -0.021200 0.975
Response of Mtb to phagocytosis 6 0.78600 0.064200 0.975
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 9 0.78700 0.052300 0.975
RHO GTPases activate IQGAPs 9 0.78700 0.052300 0.975
Cross-presentation of soluble exogenous antigens (endosomes) 12 0.79200 -0.044300 0.976
Cell Cycle, Mitotic 30 0.79300 -0.028100 0.976
Iron uptake and transport 9 0.79300 0.050800 0.976
Signaling by ERBB2 7 0.79400 -0.057200 0.976
M Phase 27 0.80000 0.028700 0.980
Downstream TCR signaling 12 0.80400 -0.041700 0.984
Plasma lipoprotein clearance 8 0.80700 0.050200 0.985
Regulation of PLK1 Activity at G2/M Transition 10 0.81200 0.043600 0.988
Signaling by SCF-KIT 5 0.81600 -0.060300 0.988
Interleukin-3, Interleukin-5 and GM-CSF signaling 5 0.81700 0.059800 0.988
CD22 mediated BCR regulation 37 0.82000 -0.022000 0.988
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 13 0.82500 0.035700 0.988
Assembly of collagen fibrils and other multimeric structures 10 0.82900 0.039600 0.988
PTEN Regulation 12 0.83400 0.035300 0.988
Activation of AMPK downstream of NMDARs 6 0.83500 -0.049400 0.988
Cargo concentration in the ER 6 0.83500 0.049400 0.988
Signaling by PDGF 8 0.83600 0.042400 0.988
RHOB GTPase cycle 10 0.83700 -0.037800 0.988
Bacterial Infection Pathways 25 0.83700 0.024100 0.988
G2/M Checkpoints 16 0.84100 -0.029300 0.988
Recycling pathway of L1 11 0.84100 0.035100 0.988
Circadian clock 14 0.84300 -0.030800 0.988
SARS-CoV-2-host interactions 16 0.84300 -0.028900 0.988
Macroautophagy 14 0.84600 0.030200 0.988
Selective autophagy 14 0.84600 0.030200 0.988
SARS-CoV-2 Infection 25 0.84700 0.022600 0.988
Role of LAT2/NTAL/LAB on calcium mobilization 47 0.84800 -0.016600 0.988
Scavenging of heme from plasma 55 0.84900 0.015300 0.988
Activation of C3 and C5 7 0.85200 0.040900 0.988
RHOJ GTPase cycle 6 0.85400 0.043400 0.988
RHOQ GTPase cycle 6 0.85400 0.043400 0.988
Mitotic Anaphase 19 0.85500 0.024400 0.988
Mitotic Metaphase and Anaphase 19 0.85500 0.024400 0.988
Glucose metabolism 15 0.85600 -0.027400 0.988
Glycolysis 15 0.85600 -0.027400 0.988
Vesicle-mediated transport 138 0.85600 -0.009670 0.988
Plasma lipoprotein assembly 12 0.86100 -0.029300 0.992
Chaperone Mediated Autophagy 9 0.86300 0.033400 0.992
Aggrephagy 11 0.86500 0.029800 0.992
Signaling by Nuclear Receptors 24 0.87400 -0.018900 0.993
Infection with Enterobacteria 8 0.87500 0.032400 0.993
Diseases of metabolism 32 0.88100 0.015600 0.993
Activated NOTCH1 Transmits Signal to the Nucleus 5 0.88300 -0.038000 0.993
Signaling by NOTCH1 5 0.88300 -0.038000 0.993
Metabolism of proteins 201 0.88400 0.006770 0.993
CDC42 GTPase cycle 8 0.88800 0.029000 0.993
Assembly and cell surface presentation of NMDA receptors 5 0.88900 0.036300 0.993
Carboxyterminal post-translational modifications of tubulin 5 0.88900 0.036300 0.993
Gap junction assembly 5 0.88900 0.036300 0.993
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 5 0.88900 0.036300 0.993
Post-chaperonin tubulin folding pathway 5 0.88900 0.036300 0.993
Sealing of the nuclear envelope (NE) by ESCRT-III 5 0.88900 0.036300 0.993
Transport of connexons to the plasma membrane 5 0.88900 0.036300 0.993
Post-translational protein modification 148 0.89100 -0.007130 0.993
Intrinsic Pathway for Apoptosis 7 0.89800 0.028200 0.993
RHOD GTPase cycle 8 0.90100 -0.025700 0.993
Signaling by TGFB family members 16 0.90200 0.018000 0.993
SARS-CoV-1 Infection 16 0.91000 -0.016500 0.993
L1CAM interactions 27 0.91200 0.012500 0.993
Golgi-to-ER retrograde transport 15 0.91200 -0.016600 0.993
RHOG GTPase cycle 9 0.91600 -0.020500 0.993
DDX58/IFIH1-mediated induction of interferon-alpha/beta 5 0.91700 -0.026900 0.993
Pre-NOTCH Expression and Processing 7 0.91700 -0.022800 0.993
Neuronal System 24 0.92200 0.011700 0.993
Hedgehog ‘on’ state 14 0.92300 0.015100 0.993
CHL1 interactions 6 0.92400 0.022600 0.993
Apoptotic execution phase 10 0.92400 0.017400 0.993
Separation of Sister Chromatids 18 0.92500 0.013000 0.993
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 5 0.92500 0.024200 0.993
G2/M DNA damage checkpoint 5 0.92500 0.024200 0.993
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 5 0.92500 0.024200 0.993
G alpha (12/13) signalling events 5 0.92500 -0.024200 0.993
Dengue Virus Attachment and Entry 7 0.92700 -0.020200 0.993
Phase I - Functionalization of compounds 10 0.92800 -0.016600 0.993
MHC class II antigen presentation 18 0.92900 0.012300 0.993
RHO GTPases Activate Formins 13 0.93000 0.014200 0.993
Gap junction trafficking 7 0.93100 0.019000 0.993
Signal transduction by L1 8 0.93300 0.017300 0.993
COPII-mediated vesicle transport 9 0.93400 -0.016000 0.993
Regulation of HSF1-mediated heat shock response 8 0.93700 0.016200 0.993
FCERI mediated Ca+2 mobilization 47 0.93900 -0.006680 0.993
RHOF GTPase cycle 9 0.94000 0.014500 0.993
Cell Cycle Checkpoints 18 0.94400 0.009660 0.993
Collagen formation 12 0.95000 0.010500 0.993
Hh mutants are degraded by ERAD 13 0.95100 -0.009930 0.993
Integrin cell surface interactions 28 0.95400 -0.006360 0.993
Cell recruitment (pro-inflammatory response) 5 0.95600 0.014500 0.993
Purinergic signaling in leishmaniasis infection 5 0.95600 0.014500 0.993
Diseases associated with the TLR signaling cascade 6 0.95700 -0.012600 0.993
Diseases of Immune System 6 0.95700 -0.012600 0.993
IRAK4 deficiency (TLR2/4) 6 0.95700 -0.012600 0.993
MyD88 deficiency (TLR2/4) 6 0.95700 -0.012600 0.993
Autophagy 19 0.95800 0.007080 0.993
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 5 0.95800 0.013600 0.993
Programmed Cell Death 33 0.95900 -0.005320 0.993
COPI-dependent Golgi-to-ER retrograde traffic 11 0.96600 -0.007430 0.993
PKR-mediated signaling 7 0.96700 -0.009080 0.993
Post-translational protein phosphorylation 53 0.97100 0.002950 0.993
GPCR ligand binding 15 0.97200 0.005320 0.993
Diseases of hemostasis 14 0.97500 0.004980 0.993
Class A/1 (Rhodopsin-like receptors) 11 0.97600 0.005190 0.993
Peptide ligand-binding receptors 11 0.97600 0.005190 0.993
Signaling by NTRKs 7 0.97900 0.005890 0.993
Antimicrobial mechanism of IFN-stimulated genes 10 0.98100 -0.004470 0.993
Interleukin-1 family signaling 15 0.98600 -0.002620 0.993
Interleukin-1 signaling 15 0.98600 -0.002620 0.993
AURKA Activation by TPX2 8 0.98700 0.003350 0.993
Centrosome maturation 8 0.98700 0.003350 0.993
Loss of Nlp from mitotic centrosomes 8 0.98700 0.003350 0.993
Loss of proteins required for interphase microtubule organization from the centrosome 8 0.98700 0.003350 0.993
Recruitment of mitotic centrosome proteins and complexes 8 0.98700 0.003350 0.993
Membrane Trafficking 67 0.98700 -0.001190 0.993
Recruitment of NuMA to mitotic centrosomes 11 0.98900 0.002340 0.993
COPI-independent Golgi-to-ER retrograde traffic 9 0.99200 0.001860 0.993
Cell Cycle 33 0.99300 -0.000939 0.993
Apoptosis 29 0.99300 -0.000906 0.993


Detailed Gene set reports



Metabolism of lipids
set Metabolism of lipids
setSize 30
pANOVA 0.00166
s.dist -0.337
p.adjustANOVA 0.488


Top enriched genes
Top 20 genes
GeneID Gene Rank
GPX1 -393
APOA1 -385
ALB -366
DECR1 -362
MGLL -350
PON1 -335
PIP4K2A -320
RAB14 -316
TSPO -296
ACLY -291
ARF3 -279
GC -254
APOA2 -249
HEXB -224
TBXAS1 -161
PTGS1 -132
PPP1CA -113
GBA1 -91
DPEP2 -44
PON3 11

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPX1 -393
APOA1 -385
ALB -366
DECR1 -362
MGLL -350
PON1 -335
PIP4K2A -320
RAB14 -316
TSPO -296
ACLY -291
ARF3 -279
GC -254
APOA2 -249
HEXB -224
TBXAS1 -161
PTGS1 -132
PPP1CA -113
GBA1 -91
DPEP2 -44
PON3 11
FABP5 17
EPHX2 19
SERPINA6 30
RAN 147
LTA4H 170
APOA5 180
PTGDS 250
BCHE 263
AGT 346
GM2A 479


Peptide hormone metabolism
set Peptide hormone metabolism
setSize 15
pANOVA 0.00394
s.dist 0.433
p.adjustANOVA 0.488


Top enriched genes
Top 20 genes
GeneID Gene Rank
IGF1 491
CTSZ 481
GNB1 418
AGT 346
INHBE 290
CPB2 282
BCHE 263
CTSD 252
ACE 166
PLA2G7 157
DPP4 150
INHBC 141
ANPEP 140
P4HB 104
CES1 -112

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGF1 491
CTSZ 481
GNB1 418
AGT 346
INHBE 290
CPB2 282
BCHE 263
CTSD 252
ACE 166
PLA2G7 157
DPP4 150
INHBC 141
ANPEP 140
P4HB 104
CES1 -112


Formation of the cornified envelope
set Formation of the cornified envelope
setSize 28
pANOVA 0.00414
s.dist 0.318
p.adjustANOVA 0.488


Top enriched genes
Top 20 genes
GeneID Gene Rank
PKP1 465
KRT71 404
KRT77 365
FLG 352
KRT6C 328
DSP 321
CAPN1 310
DSG1 303
JUP 302
KRT17 295
CASP14 288
KRT9 287
KRT14 259
KRT78 258
KRT5 254
DSC1 233
KRT16 193
KRT1 181
EVPL 165
KRT6A 162

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PKP1 465
KRT71 404
KRT77 365
FLG 352
KRT6C 328
DSP 321
CAPN1 310
DSG1 303
JUP 302
KRT17 295
CASP14 288
KRT9 287
KRT14 259
KRT78 258
KRT5 254
DSC1 233
KRT16 193
KRT1 181
EVPL 165
KRT6A 162
KRT80 106
KRT2 12
KRT10 1
DSG2 -49
SPINK5 -63
CSTA -128
CAPNS1 -137
TGM1 -299


Keratinization
set Keratinization
setSize 28
pANOVA 0.00414
s.dist 0.318
p.adjustANOVA 0.488


Top enriched genes
Top 20 genes
GeneID Gene Rank
PKP1 465
KRT71 404
KRT77 365
FLG 352
KRT6C 328
DSP 321
CAPN1 310
DSG1 303
JUP 302
KRT17 295
CASP14 288
KRT9 287
KRT14 259
KRT78 258
KRT5 254
DSC1 233
KRT16 193
KRT1 181
EVPL 165
KRT6A 162

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PKP1 465
KRT71 404
KRT77 365
FLG 352
KRT6C 328
DSP 321
CAPN1 310
DSG1 303
JUP 302
KRT17 295
CASP14 288
KRT9 287
KRT14 259
KRT78 258
KRT5 254
DSC1 233
KRT16 193
KRT1 181
EVPL 165
KRT6A 162
KRT80 106
KRT2 12
KRT10 1
DSG2 -49
SPINK5 -63
CSTA -128
CAPNS1 -137
TGM1 -299


Platelet Adhesion to exposed collagen
set Platelet Adhesion to exposed collagen
setSize 10
pANOVA 0.00456
s.dist -0.52
p.adjustANOVA 0.488


Top enriched genes
Top 20 genes
GeneID Gene Rank
FYN -369
ITGA2 -361
GP1BA -346
ITGB1 -258
FCER1G -242
GP1BB -197
ADAMTS13 -130
GP5 -126
GP9 25
VWF 133

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FYN -369
ITGA2 -361
GP1BA -346
ITGB1 -258
FCER1G -242
GP1BB -197
ADAMTS13 -130
GP5 -126
GP9 25
VWF 133


Syndecan interactions
set Syndecan interactions
setSize 10
pANOVA 0.00535
s.dist -0.511
p.adjustANOVA 0.488


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGA6 -401
ITGA2 -361
ITGB1 -258
TGFB1 -225
THBS1 -199
TNC -140
ITGB3 -98
ACTN1 -96
VTN -26
FN1 -25

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA6 -401
ITGA2 -361
ITGB1 -258
TGFB1 -225
THBS1 -199
TNC -140
ITGB3 -98
ACTN1 -96
VTN -26
FN1 -25


Diseases associated with O-glycosylation of proteins
set Diseases associated with O-glycosylation of proteins
setSize 9
pANOVA 0.00569
s.dist -0.534
p.adjustANOVA 0.488


Top enriched genes
Top 20 genes
GeneID Gene Rank
NOTCH1 -365
DAG1 -324
SPON1 -321
NOTCH2 -231
THBS1 -199
B4GAT1 -189
ADAMTS13 -130
NOTCH3 -93
CFP 109

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH1 -365
DAG1 -324
SPON1 -321
NOTCH2 -231
THBS1 -199
B4GAT1 -189
ADAMTS13 -130
NOTCH3 -93
CFP 109


Non-integrin membrane-ECM interactions
set Non-integrin membrane-ECM interactions
setSize 19
pANOVA 0.00649
s.dist -0.364
p.adjustANOVA 0.488


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGA6 -401
ITGA2 -361
LAMC1 -356
DAG1 -324
ITGB1 -258
TGFB1 -225
THBS1 -199
TNC -140
ACTB -109
ITGB3 -98
ACTN1 -96
VTN -26
FN1 -25
HSPG2 -15
TTR -7
ACTC1 4
LAMB1 28
LAMA2 34
COL4A1 377

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA6 -401
ITGA2 -361
LAMC1 -356
DAG1 -324
ITGB1 -258
TGFB1 -225
THBS1 -199
TNC -140
ACTB -109
ITGB3 -98
ACTN1 -96
VTN -26
FN1 -25
HSPG2 -15
TTR -7
ACTC1 4
LAMB1 28
LAMA2 34
COL4A1 377


Neutrophil degranulation
set Neutrophil degranulation
setSize 152
pANOVA 0.00733
s.dist 0.138
p.adjustANOVA 0.49


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 497
PRCP 486
CTSZ 481
GM2A 479
HP 476
ELANE 475
PSMD3 473
RAP1B 472
GPI 469
B4GALT1 468
CSTB 467
MLEC 466
PKP1 465
LILRA3 464
DIAPH1 460
CAT 456
CHI3L1 437
RAB10 430
LAMP2 426
OSCAR 423

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 497
PRCP 486
CTSZ 481
GM2A 479
HP 476
ELANE 475
PSMD3 473
RAP1B 472
GPI 469
B4GALT1 468
CSTB 467
MLEC 466
PKP1 465
LILRA3 464
DIAPH1 460
CAT 456
CHI3L1 437
RAB10 430
LAMP2 426
OSCAR 423
FGL2 405
ADA2 401
AHSG 400
CD44 398
TXNDC5 396
PIGR 390
PGM1 387
IQGAP2 383
IDH1 381
CAMP 380
SERPINB12 378
B2M 376
PSMD2 363
CST3 357
LYZ 353
GRN 342
GGH 337
HRNR 326
LGALS3 322
DSP 321
CFD 315
SERPINA3 311
CAPN1 310
PRSS3 307
DSG1 303
JUP 302
PTPRJ 299
CTSS 289
HBB 286
ORM1 276
ALAD 275
PNP 267
BST1 262
MMP9 260
LTF 257
CTSD 252
TIMP2 247
QSOX1 238
ORM2 234
DSC1 233
IGF2R 231
TUBB4B 230
DBNL 224
PTPRC 213
KRT1 181
PRDX6 174
NME2 172
LTA4H 170
ARPC5 167
SERPINA1 158
LRG1 153
TUBB 148
FCN1 145
ANPEP 140
PRG2 132
CD14 130
CRISP3 114
RAB6A 110
CFP 109
PSMA5 108
ACTR2 107
VAT1 102
CTSH 99
CTSC 72
ALDOA 69
FUCA2 62
ERP44 61
SIRPA 54
ITGB2 49
HSPA8 36
RAB7A 23
FABP5 17
A1BG 16
PFKL 6
LCN2 5
FLG2 0
PA2G4 -3
PKM -6
TTR -7
VCL -11
FTL -34
ALDOC -38
CD93 -41
HSPA1A -55
SELL -64
FUCA1 -68
SNAP23 -71
DYNC1H1 -73
VCP -83
PYGL -87
PGAM1 -100
C3 -102
HSP90AA1 -123
HLA-C -127
GDI2 -139
VNN1 -146
SLPI -153
PPIA -155
CAP1 -158
FTH1 -159
S100A7 -190
BIN2 -192
STOM -208
PYGB -211
GSN -215
SERPINB1 -216
CCT2 -221
HEXB -224
FCER1G -242
COTL1 -253
PPBP -255
GSTP1 -266
HSP90AB1 -271
EEF1A1 -273
ANO6 -287
ACLY -291
CALML5 -292
PECAM1 -307
AGA -308
CNN2 -312
RAB14 -316
CYB5R3 -322
ARG1 -343
ANXA2 -345
HLA-B -358
PSMB7 -368
S100A8 -370
CCT8 -379
S100A9 -380
ADAM10 -387
CTSB -391
RNASE2 -400


Mitochondrial protein degradation
set Mitochondrial protein degradation
setSize 6
pANOVA 0.00918
s.dist -0.616
p.adjustANOVA 0.553


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPD1 -398
IDH2 -374
ATP5F1B -341
ATP5F1A -237
ACO2 -104
APP 68

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPD1 -398
IDH2 -374
ATP5F1B -341
ATP5F1A -237
ACO2 -104
APP 68


EPHA-mediated growth cone collapse
set EPHA-mediated growth cone collapse
setSize 7
pANOVA 0.011
s.dist -0.557
p.adjustANOVA 0.603


Top enriched genes
Top 20 genes
GeneID Gene Rank
FYN -369
MYL9 -277
SRC -270
ROCK2 -256
MYL6 -156
MYH9 -97
MYL12B -4

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FYN -369
MYL9 -277
SRC -270
ROCK2 -256
MYL6 -156
MYH9 -97
MYL12B -4


Cellular responses to stimuli
set Cellular responses to stimuli
setSize 86
pANOVA 0.0123
s.dist -0.164
p.adjustANOVA 0.616


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPD1 -398
GPX1 -393
CAPZA1 -390
APOA1 -385
FYN -369
PSMB7 -368
ALB -366
NOTCH1 -365
TUBA8 -364
PRDX5 -363
PDIA5 -357
ANXA2 -345
PSMB3 -331
PRDX1 -329
PECAM1 -307
STIP1 -275
EEF1A1 -273
GSR -272
HSP90AB1 -271
PRDX3 -269

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPD1 -398
GPX1 -393
CAPZA1 -390
APOA1 -385
FYN -369
PSMB7 -368
ALB -366
NOTCH1 -365
TUBA8 -364
PRDX5 -363
PDIA5 -357
ANXA2 -345
PSMB3 -331
PRDX1 -329
PECAM1 -307
STIP1 -275
EEF1A1 -273
GSR -272
HSP90AB1 -271
PRDX3 -269
GSTP1 -266
PSMB2 -265
HSPA4 -264
FLT4 -261
ITGB1 -258
APOB -240
PGD -235
GPX3 -230
GNB2 -223
PSMA6 -205
TKT -196
CALM1 -169
HSPB1 -168
PSMA1 -142
CAPNS1 -137
HSP90AA1 -123
CSRP1 -121
ITGB3 -98
TLN1 -86
VCP -83
HSP90B1 -77
DYNC1H1 -73
TUBA4A -57
HSPA1A -55
EXTL2 -47
HSPA5 -45
HYOU1 -37
G6PD -29
FN1 -25
HSPG2 -15
VCL -11
TALDO1 -2
TUBB1 22
CDH5 27
HSPA8 36
CALR 64
TXN 71
PDIA6 76
P4HB 104
PSMA5 108
YWHAE 115
PSMA7 129
HSPE1 152
PSMA4 171
PRDX6 174
TUBB4B 230
HBB 286
RPS27A 305
ST13 306
SOD3 319
SOD2 331
PRKAR1A 335
DPP3 338
BLVRB 341
PRDX2 362
PSMD2 363
GNAQ 366
IDH1 381
GNB1 418
SOD1 434
CACNA2D1 455
CAT 456
ACTR1A 461
PSMD3 473
TUBA1C 478
MAPK1 497


Innate Immune System
set Innate Immune System
setSize 277
pANOVA 0.0171
s.dist 0.0993
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 497
CFHR2 489
PRCP 486
CTSZ 481
GM2A 479
HP 476
ELANE 475
PSMD3 473
RAP1B 472
GPI 469
B4GALT1 468
CSTB 467
MLEC 466
PKP1 465
LILRA3 464
IGLV7-43 463
DIAPH1 460
CAT 456
CFHR4 454
IGHV1-46 446

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 497
CFHR2 489
PRCP 486
CTSZ 481
GM2A 479
HP 476
ELANE 475
PSMD3 473
RAP1B 472
GPI 469
B4GALT1 468
CSTB 467
MLEC 466
PKP1 465
LILRA3 464
IGLV7-43 463
DIAPH1 460
CAT 456
CFHR4 454
IGHV1-46 446
CFHR1 439
CHI3L1 437
RAB10 430
IGLV3-19 427
LAMP2 426
OSCAR 423
CFL1 416
IGLV2-8 406
FGL2 405
ADA2 401
AHSG 400
CD44 398
TXNDC5 396
PIGR 390
PGM1 387
IGLV4-69 385
IQGAP2 383
IDH1 381
CAMP 380
SERPINB12 378
B2M 376
IGHV3-48 371
GRB2 368
COLEC10 364
PSMD2 363
CPN1 359
CST3 357
MASP2 356
PRKCSH 355
LYZ 353
FGB 343
GRN 342
CFH 340
GGH 337
IGLV8-61 336
HRNR 326
LGALS3 322
DSP 321
C4BPA 318
C2 317
CFD 315
SERPINA3 311
CAPN1 310
IGLV1-44 308
PRSS3 307
RPS27A 305
DSG1 303
JUP 302
IGLV1-40 300
PTPRJ 299
FGA 297
C4BPB 292
CTSS 289
HBB 286
IGHV3-13 285
CPB2 282
CFB 277
ORM1 276
ALAD 275
PNP 267
BST1 262
MMP9 260
LTF 257
CTSD 252
TIMP2 247
C9 244
QSOX1 238
ORM2 234
DSC1 233
IGF2R 231
TUBB4B 230
DBNL 224
FGG 219
COLEC11 215
PTPRC 213
C1QC 211
IGHV3-7 205
CRP 201
MASP1 199
CFHR5 197
MBL2 191
C6 190
SAA1 188
IGHV3-23 186
SERPING1 184
IGHE 182
KRT1 181
PRDX6 174
NME2 172
PSMA4 171
LTA4H 170
ARPC5 167
C1QA 161
SERPINA1 158
LRG1 153
TUBB 148
IGHV4-34 146
FCN1 145
IGLV6-57 144
ANPEP 140
FCN3 136
IGLV4-3 134
PRG2 132
IGHV1-69 131
CD14 130
PSMA7 129
C8G 127
IGLV2-11 122
C4B 117
IGLV2-14 116
CRISP3 114
IGKV3-11 113
IGKV1D-33 111
RAB6A 110
CFP 109
PSMA5 108
ACTR2 107
VAT1 102
CTSH 99
C7 88
UBE2V1 85
LBP 82
IGLC7 81
IGKV4-1 80
C8B 78
CFI 75
CTSC 72
TXN 71
ALDOA 69
APP 68
IGHG3 65
PROS1 63
FUCA2 62
ERP44 61
FCGR3A 60
C1S 56
SYK 55
SIRPA 54
IGLV1-47 53
ITGB2 49
C5 48
FCN2 45
C8A 44
IGLV1-36 40
HSPA8 36
IGLV1-51 29
RAB7A 23
FABP5 17
A1BG 16
PFKL 6
LCN2 5
FLG2 0
PA2G4 -3
PKM -6
TTR -7
IGHV2-70 -10
VCL -11
C1R -16
C1QB -24
VTN -26
BPIFB1 -27
FTL -34
ALDOC -38
CD93 -41
IGHV3-30 -46
ACTR3 -54
HSPA1A -55
SELL -64
CLU -65
FUCA1 -68
SNAP23 -71
ARPC3 -72
DYNC1H1 -73
HSP90B1 -77
PGLYRP2 -79
CPN2 -81
VCP -83
IGHG2 -85
PYGL -87
IGHV2-5 -94
MYH9 -97
PGAM1 -100
C3 -102
ACTB -109
HSP90AA1 -123
HLA-C -127
GDI2 -139
PSMA1 -142
IGKV1-17 -143
VNN1 -146
SLPI -153
PPIA -155
CAP1 -158
FTH1 -159
IGHV3-9 -165
IGLV2-18 -167
CALM1 -169
ARPC2 -171
F2 -177
IGHG4 -185
IGHV1-2 -186
S100A7 -190
BIN2 -192
PSMA6 -205
STOM -208
IGKV1-16 -209
PYGB -211
GSN -215
SERPINB1 -216
CCT2 -221
HEXB -224
ARPC1B -228
APOB -240
FCER1G -242
IGLC2 -244
COTL1 -253
PPBP -255
IGKV1-5 -260
IGKV3D-20 -262
CHGA -263
PSMB2 -265
GSTP1 -266
SRC -270
HSP90AB1 -271
EEF1A1 -273
IGLV3-16 -282
IGKC -284
IGLV4-60 -285
ANO6 -287
IGLV2-23 -290
ACLY -291
CALML5 -292
ITLN1 -302
PECAM1 -307
AGA -308
CNN2 -312
RAB14 -316
C4A -319
CYB5R3 -322
PSMB3 -331
IGKV3-20 -333
IGHG1 -337
ARG1 -343
ANXA2 -345
IGKV1D-16 -348
HLA-B -358
PSMB7 -368
FYN -369
S100A8 -370
CCT8 -379
S100A9 -380
ADAM10 -387
CAPZA1 -390
CTSB -391
RNASE2 -400
RASGRP2 -402
ARPC4 -403


Diseases of carbohydrate metabolism
set Diseases of carbohydrate metabolism
setSize 6
pANOVA 0.0185
s.dist 0.557
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
DCXR 442
HYAL1 410
ALDOB 339
RPS27A 305
NAGLU 280
TALDO1 -2

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DCXR 442
HYAL1 410
ALDOB 339
RPS27A 305
NAGLU 280
TALDO1 -2


RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
set RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
setSize 5
pANOVA 0.02
s.dist -0.602
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
GP1BA -346
MYL9 -277
PF4 -252
THBS1 -199
ITGA2B -52

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP1BA -346
MYL9 -277
PF4 -252
THBS1 -199
ITGA2B -52


RHOBTB GTPase Cycle
set RHOBTB GTPase Cycle
setSize 8
pANOVA 0.0205
s.dist -0.475
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBN1 -399
CCT6A -339
HSP90AB1 -271
ROCK2 -256
CCT2 -221
HSP90AA1 -123
ACTN1 -96
TXNL1 367

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBN1 -399
CCT6A -339
HSP90AB1 -271
ROCK2 -256
CCT2 -221
HSP90AA1 -123
ACTN1 -96
TXNL1 367


Signaling by Rho GTPases
set Signaling by Rho GTPases
setSize 70
pANOVA 0.0245
s.dist -0.162
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARPC4 -403
DBN1 -399
TPM3 -394
S100A9 -380
S100A8 -370
TUBA8 -364
CCT6A -339
FLOT2 -326
YWHAG -325
ARHGDIB -305
MYL9 -277
STIP1 -275
HSP90AB1 -271
SRC -270
ITGB1 -258
ROCK2 -256
BCAP31 -233
ARPC1B -228
CCT2 -221
STOM -208

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARPC4 -403
DBN1 -399
TPM3 -394
S100A9 -380
S100A8 -370
TUBA8 -364
CCT6A -339
FLOT2 -326
YWHAG -325
ARHGDIB -305
MYL9 -277
STIP1 -275
HSP90AB1 -271
SRC -270
ITGB1 -258
ROCK2 -256
BCAP31 -233
ARPC1B -228
CCT2 -221
STOM -208
TPM4 -178
ARPC2 -171
CALM1 -169
MYL6 -156
CTTN -150
PFN1 -148
HSP90AA1 -123
ACTB -109
BASP1 -103
MYH9 -97
ACTN1 -96
VCP -83
PLXNB1 -80
DYNC1H1 -73
ARPC3 -72
SNAP23 -71
AKAP12 -70
TUBA4A -57
ACTR3 -54
TFRC -53
FLNA -51
DSG2 -49
MYL12B -4
YWHAZ 3
ACTC1 4
TUBB1 22
RAB7A 23
MCAM 37
YWHAB 58
ACTR2 107
YWHAE 115
HSPE1 152
ARPC5 167
CLTC 178
CDH1 206
TUBB4B 230
JUP 302
DSG1 303
RHOC 314
DSP 321
TXNL1 367
GRB2 368
IQGAP2 383
ARHGAP1 397
CFL1 416
YWHAH 431
KIF2A 449
DIAPH1 460
TUBA1C 478
MAPK1 497


Signaling by Rho GTPases, Miro GTPases and RHOBTB3
set Signaling by Rho GTPases, Miro GTPases and RHOBTB3
setSize 70
pANOVA 0.0245
s.dist -0.162
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARPC4 -403
DBN1 -399
TPM3 -394
S100A9 -380
S100A8 -370
TUBA8 -364
CCT6A -339
FLOT2 -326
YWHAG -325
ARHGDIB -305
MYL9 -277
STIP1 -275
HSP90AB1 -271
SRC -270
ITGB1 -258
ROCK2 -256
BCAP31 -233
ARPC1B -228
CCT2 -221
STOM -208

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARPC4 -403
DBN1 -399
TPM3 -394
S100A9 -380
S100A8 -370
TUBA8 -364
CCT6A -339
FLOT2 -326
YWHAG -325
ARHGDIB -305
MYL9 -277
STIP1 -275
HSP90AB1 -271
SRC -270
ITGB1 -258
ROCK2 -256
BCAP31 -233
ARPC1B -228
CCT2 -221
STOM -208
TPM4 -178
ARPC2 -171
CALM1 -169
MYL6 -156
CTTN -150
PFN1 -148
HSP90AA1 -123
ACTB -109
BASP1 -103
MYH9 -97
ACTN1 -96
VCP -83
PLXNB1 -80
DYNC1H1 -73
ARPC3 -72
SNAP23 -71
AKAP12 -70
TUBA4A -57
ACTR3 -54
TFRC -53
FLNA -51
DSG2 -49
MYL12B -4
YWHAZ 3
ACTC1 4
TUBB1 22
RAB7A 23
MCAM 37
YWHAB 58
ACTR2 107
YWHAE 115
HSPE1 152
ARPC5 167
CLTC 178
CDH1 206
TUBB4B 230
JUP 302
DSG1 303
RHOC 314
DSP 321
TXNL1 367
GRB2 368
IQGAP2 383
ARHGAP1 397
CFL1 416
YWHAH 431
KIF2A 449
DIAPH1 460
TUBA1C 478
MAPK1 497


Muscle contraction
set Muscle contraction
setSize 16
pANOVA 0.027
s.dist -0.322
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
TPM3 -394
ANXA2 -345
MYL9 -277
TTN -181
TPM4 -178
CALM1 -169
MYL6 -156
ATP2A3 -117
CES1 -112
TLN1 -86
CALD1 -18
VCL -11
MYL12B -4
ACTC1 4
ANXA1 46
TPM1 438

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TPM3 -394
ANXA2 -345
MYL9 -277
TTN -181
TPM4 -178
CALM1 -169
MYL6 -156
ATP2A3 -117
CES1 -112
TLN1 -86
CALD1 -18
VCL -11
MYL12B -4
ACTC1 4
ANXA1 46
TPM1 438


EPH-Ephrin signaling
set EPH-Ephrin signaling
setSize 20
pANOVA 0.0276
s.dist -0.288
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARPC4 -403
ADAM10 -387
FYN -369
MYL9 -277
SRC -270
ROCK2 -256
ARPC1B -228
ARPC2 -171
MYL6 -156
ACTB -109
MYH9 -97
ARPC3 -72
ACTR3 -54
MYL12B -4
MMP2 92
ACTR2 107
ARPC5 167
CLTC 178
MMP9 260
CFL1 416

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARPC4 -403
ADAM10 -387
FYN -369
MYL9 -277
SRC -270
ROCK2 -256
ARPC1B -228
ARPC2 -171
MYL6 -156
ACTB -109
MYH9 -97
ARPC3 -72
ACTR3 -54
MYL12B -4
MMP2 92
ACTR2 107
ARPC5 167
CLTC 178
MMP9 260
CFL1 416


Scavenging by Class B Receptors
set Scavenging by Class B Receptors
setSize 7
pANOVA 0.0284
s.dist -0.48
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
APOA1 -385
S100A9 -380
PRDX1 -329
APOB -240
CD5L -182
SSC5D 139
SAA1 188

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOA1 -385
S100A9 -380
PRDX1 -329
APOB -240
CD5L -182
SSC5D 139
SAA1 188


Lysosome Vesicle Biogenesis
set Lysosome Vesicle Biogenesis
setSize 6
pANOVA 0.0301
s.dist 0.513
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARRB1 496
CTSZ 481
TXNDC5 396
CLTC 178
APP 68
HSPA8 36

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARRB1 496
CTSZ 481
TXNDC5 396
CLTC 178
APP 68
HSPA8 36


Folding of actin by CCT/TriC
set Folding of actin by CCT/TriC
setSize 6
pANOVA 0.0303
s.dist -0.512
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCT8 -379
CCT6A -339
CCT2 -221
CCT5 -201
ACTB -109
TCP1 142

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT8 -379
CCT6A -339
CCT2 -221
CCT5 -201
ACTB -109
TCP1 142


Association of TriC/CCT with target proteins during biosynthesis
set Association of TriC/CCT with target proteins during biosynthesis
setSize 6
pANOVA 0.0326
s.dist -0.506
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
CCT8 -379
CCT6A -339
CCT2 -221
CCT5 -201
GBA1 -91
TCP1 142

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT8 -379
CCT6A -339
CCT2 -221
CCT5 -201
GBA1 -91
TCP1 142


Sensory processing of sound
set Sensory processing of sound
setSize 5
pANOVA 0.0329
s.dist -0.552
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
CAPZA1 -390
GSN -215
MSN -203
ACTB -109
MYH9 -97

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CAPZA1 -390
GSN -215
MSN -203
ACTB -109
MYH9 -97


Phospholipid metabolism
set Phospholipid metabolism
setSize 5
pANOVA 0.0346
s.dist -0.547
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
MGLL -350
PIP4K2A -320
RAB14 -316
ARF3 -279
BCHE 263

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MGLL -350
PIP4K2A -320
RAB14 -316
ARF3 -279
BCHE 263


Mitochondrial biogenesis
set Mitochondrial biogenesis
setSize 6
pANOVA 0.0356
s.dist -0.497
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
IDH2 -374
ATP5F1B -341
ATP5PB -276
ATP5F1A -237
CALM1 -169
SOD2 331

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IDH2 -374
ATP5F1B -341
ATP5PB -276
ATP5F1A -237
CALM1 -169
SOD2 331


Antigen Presentation: Folding, assembly and peptide loading of class I MHC
set Antigen Presentation: Folding, assembly and peptide loading of class I MHC
setSize 10
pANOVA 0.0358
s.dist -0.385
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
HLA-A -392
HLA-B -358
CANX -352
BCAP31 -233
ERAP2 -180
HLA-C -127
HSPA5 -45
PDIA3 -21
CALR 64
B2M 376

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HLA-A -392
HLA-B -358
CANX -352
BCAP31 -233
ERAP2 -180
HLA-C -127
HSPA5 -45
PDIA3 -21
CALR 64
B2M 376


MET activates PTK2 signaling
set MET activates PTK2 signaling
setSize 8
pANOVA 0.0393
s.dist -0.423
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGA2 -361
LAMC1 -356
SRC -270
ITGB1 -258
FN1 -25
LAMB1 28
LAMA2 34
MET 57

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA2 -361
LAMC1 -356
SRC -270
ITGB1 -258
FN1 -25
LAMB1 28
LAMA2 34
MET 57


Signal Transduction
set Signal Transduction
setSize 187
pANOVA 0.0395
s.dist -0.0976
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
VPS29 -404
ARPC4 -403
RASGRP2 -402
DBN1 -399
TPM3 -394
ADAM10 -387
HGFAC -383
IHH -382
CILP -381
S100A9 -380
S100A8 -370
FYN -369
PSMB7 -368
NOTCH1 -365
TUBA8 -364
ITGA2 -361
LAMC1 -356
MGLL -350
GNAI2 -340
CCT6A -339

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VPS29 -404
ARPC4 -403
RASGRP2 -402
DBN1 -399
TPM3 -394
ADAM10 -387
HGFAC -383
IHH -382
CILP -381
S100A9 -380
S100A8 -370
FYN -369
PSMB7 -368
NOTCH1 -365
TUBA8 -364
ITGA2 -361
LAMC1 -356
MGLL -350
GNAI2 -340
CCT6A -339
TIMP1 -336
PSMB3 -331
FLOT2 -326
YWHAG -325
PIP4K2A -320
ARHGDIB -305
GPNMB -297
MYL9 -277
STIP1 -275
HSP90AB1 -271
SRC -270
PSMB2 -265
FLT4 -261
ITGB1 -258
ROCK2 -256
PPBP -255
PF4 -252
FGFBP2 -238
BCAP31 -233
EGFR -232
NOTCH2 -231
ARPC1B -228
TGFB1 -225
GNB2 -223
CCT2 -221
LTBP1 -219
STOM -208
PSMA6 -205
THBS1 -199
TPM4 -178
F2 -177
ARPC2 -171
SPARC -170
CALM1 -169
HSPB1 -168
MYL6 -156
CTTN -150
FKBP1A -149
PFN1 -148
PSMA1 -142
STRAP -136
PLG -135
CDK5R2 -125
HSP90AA1 -123
ATP2A3 -117
ANGPTL3 -116
LYPLA1 -114
PPP1CA -113
ACTB -109
BASP1 -103
C3 -102
ITGB3 -98
MYH9 -97
ACTN1 -96
NOTCH3 -93
TLN1 -86
VCP -83
PLXNB1 -80
CETP -75
DYNC1H1 -73
ARPC3 -72
SNAP23 -71
AKAP12 -70
COL6A1 -59
TUBA4A -57
ACTR3 -54
TFRC -53
ITGA2B -52
FLNA -51
DSG2 -49
FN1 -25
F11R -22
PLTP -17
VCL -11
MYL12B -4
APOD 2
YWHAZ 3
ACTC1 4
IL6R 10
FABP5 17
TUBB1 22
RAB7A 23
CDH5 27
LAMB1 28
APOC1 33
LAMA2 34
MCAM 37
NCAM1 43
ANXA1 46
C5 48
SYK 55
MET 57
YWHAB 58
APP 68
APOE 84
IL1RAP 86
MMP2 92
CNTN1 93
KIT 103
P4HB 104
ACTR2 107
PSMA5 108
RAB6A 110
YWHAE 115
PTPRF 118
ADH4 123
PSMA7 129
VWF 133
HSPE1 152
FBN1 163
ARPC5 167
PSMA4 171
CLTC 178
NRP2 179
SAA1 188
CDH1 206
PEBP1 210
COL6A3 216
THBS4 218
FGG 219
SERPINE1 220
TUBB4B 230
TIMP2 247
MST1 248
IGF2 251
CTSD 252
NRP1 255
MMP9 260
CCL5 284
FGA 297
PTPRJ 299
JUP 302
DSG1 303
RPS27A 305
RHOC 314
APOC2 316
DSP 321
KNG1 332
PRKAR1A 335
FGB 343
AGT 346
PSMD2 363
GNAQ 366
TXNL1 367
GRB2 368
APOC4 373
SPTA1 374
COL4A1 377
SHH 379
IQGAP2 383
SPTB 391
ARHGAP1 397
CFL1 416
GNB1 418
ALDH1A1 429
YWHAH 431
KIF2A 449
DIAPH1 460
B4GALT1 468
RAP1B 472
PSMD3 473
ELANE 475
TUBA1C 478
FSTL1 484
IGF1 491
ARRB1 496
MAPK1 497


VEGFA-VEGFR2 Pathway
set VEGFA-VEGFR2 Pathway
setSize 10
pANOVA 0.0397
s.dist -0.378
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
FYN -369
SRC -270
ROCK2 -256
CALM1 -169
HSPB1 -168
HSP90AA1 -123
ACTB -109
ITGB3 -98
CDH5 27
JUP 302

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FYN -369
SRC -270
ROCK2 -256
CALM1 -169
HSPB1 -168
HSP90AA1 -123
ACTB -109
ITGB3 -98
CDH5 27
JUP 302


Fatty acid metabolism
set Fatty acid metabolism
setSize 11
pANOVA 0.0398
s.dist -0.36
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
GPX1 -393
DECR1 -362
PON1 -335
ACLY -291
TBXAS1 -161
PTGS1 -132
DPEP2 -44
PON3 11
EPHX2 19
LTA4H 170
PTGDS 250

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPX1 -393
DECR1 -362
PON1 -335
ACLY -291
TBXAS1 -161
PTGS1 -132
DPEP2 -44
PON3 11
EPHX2 19
LTA4H 170
PTGDS 250


RHOBTB2 GTPase cycle
set RHOBTB2 GTPase cycle
setSize 7
pANOVA 0.0418
s.dist -0.446
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBN1 -399
CCT6A -339
HSP90AB1 -271
CCT2 -221
HSP90AA1 -123
ACTN1 -96
TXNL1 367

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBN1 -399
CCT6A -339
HSP90AB1 -271
CCT2 -221
HSP90AA1 -123
ACTN1 -96
TXNL1 367


Cellular responses to stress
set Cellular responses to stress
setSize 68
pANOVA 0.0422
s.dist -0.148
p.adjustANOVA 0.747


Top enriched genes
Top 20 genes
GeneID Gene Rank
HSPD1 -398
GPX1 -393
CAPZA1 -390
APOA1 -385
PSMB7 -368
ALB -366
NOTCH1 -365
TUBA8 -364
PRDX5 -363
PDIA5 -357
PSMB3 -331
PRDX1 -329
STIP1 -275
EEF1A1 -273
GSR -272
HSP90AB1 -271
PRDX3 -269
GSTP1 -266
PSMB2 -265
HSPA4 -264

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPD1 -398
GPX1 -393
CAPZA1 -390
APOA1 -385
PSMB7 -368
ALB -366
NOTCH1 -365
TUBA8 -364
PRDX5 -363
PDIA5 -357
PSMB3 -331
PRDX1 -329
STIP1 -275
EEF1A1 -273
GSR -272
HSP90AB1 -271
PRDX3 -269
GSTP1 -266
PSMB2 -265
HSPA4 -264
APOB -240
PGD -235
GPX3 -230
PSMA6 -205
TKT -196
HSPB1 -168
PSMA1 -142
HSP90AA1 -123
TLN1 -86
VCP -83
HSP90B1 -77
DYNC1H1 -73
TUBA4A -57
HSPA1A -55
EXTL2 -47
HSPA5 -45
HYOU1 -37
G6PD -29
TALDO1 -2
TUBB1 22
HSPA8 36
CALR 64
TXN 71
PDIA6 76
P4HB 104
PSMA5 108
YWHAE 115
PSMA7 129
HSPE1 152
PSMA4 171
PRDX6 174
TUBB4B 230
HBB 286
RPS27A 305
ST13 306
SOD3 319
SOD2 331
DPP3 338
BLVRB 341
PRDX2 362
PSMD2 363
IDH1 381
SOD1 434
CAT 456
ACTR1A 461
PSMD3 473
TUBA1C 478
MAPK1 497


Immune System
set Immune System
setSize 337
pANOVA 0.0448
s.dist 0.0797
p.adjustANOVA 0.757


Top enriched genes
Top 20 genes
GeneID Gene Rank
MAPK1 497
CFHR2 489
STXBP2 488
PRCP 486
CSF1R 483
CTSZ 481
GM2A 479
TUBA1C 478
HP 476
ELANE 475
PSMD3 473
RAP1B 472
GPI 469
B4GALT1 468
CSTB 467
MLEC 466
PKP1 465
LILRA3 464
IGLV7-43 463
ACTR1A 461

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK1 497
CFHR2 489
STXBP2 488
PRCP 486
CSF1R 483
CTSZ 481
GM2A 479
TUBA1C 478
HP 476
ELANE 475
PSMD3 473
RAP1B 472
GPI 469
B4GALT1 468
CSTB 467
MLEC 466
PKP1 465
LILRA3 464
IGLV7-43 463
ACTR1A 461
DIAPH1 460
CAT 456
CFHR4 454
KIF2A 449
IGHV1-46 446
CFHR1 439
CHI3L1 437
SOD1 434
RAB10 430
IGLV3-19 427
LAMP2 426
OSCAR 423
CFL1 416
IGLV2-8 406
FGL2 405
ADA2 401
AHSG 400
CD44 398
TXNDC5 396
PIGR 390
PGM1 387
IGLV4-69 385
IQGAP2 383
IDH1 381
CAMP 380
SERPINB12 378
B2M 376
IGHV3-48 371
GRB2 368
COLEC10 364
PSMD2 363
FYB1 361
CPN1 359
CST3 357
MASP2 356
PRKCSH 355
LYZ 353
FGB 343
GRN 342
CFH 340
GGH 337
IGLV8-61 336
SOD2 331
FSCN1 327
HRNR 326
LGALS3 322
DSP 321
C4BPA 318
C2 317
CFD 315
SERPINA3 311
CAPN1 310
IGLV1-44 308
PRSS3 307
RPS27A 305
DSG1 303
JUP 302
IGLV1-40 300
PTPRJ 299
FGA 297
ICOSLG 293
C4BPB 292
CTSS 289
HBB 286
IGHV3-13 285
CCL5 284
BLMH 283
CPB2 282
CFB 277
ORM1 276
ALAD 275
UBA1 272
PNP 267
ICAM1 266
BST1 262
MMP9 260
LTF 257
CTSD 252
TIMP2 247
C9 244
CA1 240
QSOX1 238
ORM2 234
DSC1 233
IGF2R 231
TUBB4B 230
DBNL 224
FGG 219
MRC1 217
COLEC11 215
PTPRC 213
C1QC 211
CDH1 206
IGHV3-7 205
CRP 201
MASP1 199
CFHR5 197
MBL2 191
C6 190
SAA1 188
IGHV3-23 186
SERPING1 184
IGHE 182
KRT1 181
CLTC 178
PRDX6 174
NME2 172
PSMA4 171
LTA4H 170
ARPC5 167
C1QA 161
MRC2 159
SERPINA1 158
LRG1 153
TUBB 148
IGHV4-34 146
FCN1 145
IGLV6-57 144
TCP1 142
ANPEP 140
VCAM1 137
FCN3 136
IGLV4-3 134
PRG2 132
IGHV1-69 131
CD14 130
PSMA7 129
C8G 127
IGLV2-11 122
C4B 117
IGLV2-14 116
CRISP3 114
IGKV3-11 113
IGKV1D-33 111
RAB6A 110
CFP 109
PSMA5 108
ACTR2 107
P4HB 104
VAT1 102
CTSH 99
MMP2 92
C7 88
IL1RAP 86
UBE2V1 85
LBP 82
IGLC7 81
IGKV4-1 80
C8B 78
CFI 75
CTSC 72
TXN 71
ALDOA 69
APP 68
IGHG3 65
CALR 64
PROS1 63
FUCA2 62
ERP44 61
FCGR3A 60
YWHAB 58
C1S 56
SYK 55
SIRPA 54
IGLV1-47 53
ITGB2 49
C5 48
ANXA1 46
FCN2 45
C8A 44
NCAM1 43
IGLV1-36 40
HSPA8 36
IGLV1-51 29
RAB7A 23
TUBB1 22
FABP5 17
A1BG 16
IL6R 10
PFKL 6
LCN2 5
YWHAZ 3
FLG2 0
TALDO1 -2
PA2G4 -3
PKM -6
TTR -7
CTSF -9
IGHV2-70 -10
VCL -11
C1R -16
PDIA3 -21
C1QB -24
FN1 -25
VTN -26
BPIFB1 -27
LILRA2 -28
FTL -34
ALDOC -38
F13A1 -39
CD93 -41
HSPA5 -45
IGHV3-30 -46
FLNA -51
ACTR3 -54
HSPA1A -55
TUBA4A -57
VASP -60
SELL -64
CLU -65
FUCA1 -68
SNAP23 -71
ARPC3 -72
DYNC1H1 -73
HSP90B1 -77
PGLYRP2 -79
CPN2 -81
VCP -83
IGHG2 -85
PYGL -87
IGHV2-5 -94
MYH9 -97
PGAM1 -100
C3 -102
ACTB -109
HSP90AA1 -123
HLA-C -127
IGHM -131
PVR -133
GDI2 -139
PSMA1 -142
IGKV1-17 -143
VNN1 -146
FKBP1A -149
SLPI -153
PPIA -155
CAP1 -158
FTH1 -159
IGHV3-9 -165
IGLV2-18 -167
CALM1 -169
ARPC2 -171
F2 -177
ERAP2 -180
IGHG4 -185
IGHV1-2 -186
IGHD -188
S100A7 -190
BIN2 -192
MSN -203
PSMA6 -205
STOM -208
IGKV1-16 -209
PYGB -211
GSN -215
SERPINB1 -216
CCT2 -221
HEXB -224
TGFB1 -225
ARPC1B -228
BCAP31 -233
APOB -240
FCER1G -242
IGLC2 -244
COTL1 -253
PPBP -255
ITGB1 -258
IGKV1-5 -260
IGKV3D-20 -262
CHGA -263
PSMB2 -265
GSTP1 -266
LCP1 -267
SRC -270
HSP90AB1 -271
EEF1A1 -273
GSTO1 -281
IGLV3-16 -282
IGKC -284
IGLV4-60 -285
ANO6 -287
IGLV2-23 -290
ACLY -291
CALML5 -292
UBE2O -293
ITLN1 -302
PECAM1 -307
AGA -308
CNN2 -312
CD99 -315
RAB14 -316
C4A -319
CYB5R3 -322
YWHAG -325
PSMB3 -331
IGKV3-20 -333
TPP2 -334
TIMP1 -336
IGHG1 -337
ARG1 -343
ANXA2 -345
IGKV1D-16 -348
CANX -352
HLA-B -358
TUBA8 -364
PSMB7 -368
FYN -369
S100A8 -370
CCT8 -379
S100A9 -380
ADAM10 -387
CAPZA1 -390
CTSB -391
HLA-A -392
RNASE2 -400
RASGRP2 -402
ARPC4 -403


Cell-extracellular matrix interactions
set Cell-extracellular matrix interactions
setSize 9
pANOVA 0.0453
s.dist -0.387
p.adjustANOVA 0.757


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGB1 -258
RSU1 -245
PARVB -236
LIMS1 -174
ACTB -109
ACTN1 -96
VASP -60
FLNA -51
ILK 79

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGB1 -258
RSU1 -245
PARVB -236
LIMS1 -174
ACTB -109
ACTN1 -96
VASP -60
FLNA -51
ILK 79


EPHB-mediated forward signaling
set EPHB-mediated forward signaling
setSize 12
pANOVA 0.0465
s.dist -0.334
p.adjustANOVA 0.757


Top enriched genes
Top 20 genes
GeneID Gene Rank
ARPC4 -403
FYN -369
SRC -270
ROCK2 -256
ARPC1B -228
ARPC2 -171
ACTB -109
ARPC3 -72
ACTR3 -54
ACTR2 107
ARPC5 167
CFL1 416

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARPC4 -403
FYN -369
SRC -270
ROCK2 -256
ARPC1B -228
ARPC2 -171
ACTB -109
ARPC3 -72
ACTR3 -54
ACTR2 107
ARPC5 167
CFL1 416


Complement cascade
set Complement cascade
setSize 91
pANOVA 0.0557
s.dist 0.122
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
CFHR2 489
ELANE 475
IGLV7-43 463
CFHR4 454
IGHV1-46 446
CFHR1 439
IGLV3-19 427
IGLV2-8 406
IGLV4-69 385
IGHV3-48 371
COLEC10 364
CPN1 359
MASP2 356
CFH 340
IGLV8-61 336
C4BPA 318
C2 317
CFD 315
IGLV1-44 308
IGLV1-40 300

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CFHR2 489
ELANE 475
IGLV7-43 463
CFHR4 454
IGHV1-46 446
CFHR1 439
IGLV3-19 427
IGLV2-8 406
IGLV4-69 385
IGHV3-48 371
COLEC10 364
CPN1 359
MASP2 356
CFH 340
IGLV8-61 336
C4BPA 318
C2 317
CFD 315
IGLV1-44 308
IGLV1-40 300
C4BPB 292
IGHV3-13 285
CPB2 282
CFB 277
C9 244
COLEC11 215
C1QC 211
IGHV3-7 205
CRP 201
MASP1 199
CFHR5 197
MBL2 191
C6 190
IGHV3-23 186
SERPING1 184
C1QA 161
IGHV4-34 146
FCN1 145
IGLV6-57 144
FCN3 136
IGLV4-3 134
IGHV1-69 131
C8G 127
IGLV2-11 122
C4B 117
IGLV2-14 116
IGKV3-11 113
IGKV1D-33 111
CFP 109
C7 88
IGLC7 81
IGKV4-1 80
C8B 78
CFI 75
IGHG3 65
PROS1 63
C1S 56
IGLV1-47 53
C5 48
FCN2 45
C8A 44
IGLV1-36 40
IGLV1-51 29
IGHV2-70 -10
C1R -16
C1QB -24
VTN -26
IGHV3-30 -46
CLU -65
CPN2 -81
IGHG2 -85
IGHV2-5 -94
C3 -102
IGKV1-17 -143
IGHV3-9 -165
IGLV2-18 -167
F2 -177
IGHG4 -185
IGHV1-2 -186
IGKV1-16 -209
IGLC2 -244
IGKV1-5 -260
IGKV3D-20 -262
IGLV3-16 -282
IGKC -284
IGLV4-60 -285
IGLV2-23 -290
C4A -319
IGKV3-20 -333
IGHG1 -337
IGKV1D-16 -348


Smooth Muscle Contraction
set Smooth Muscle Contraction
setSize 12
pANOVA 0.0584
s.dist -0.318
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
TPM3 -394
ANXA2 -345
MYL9 -277
TPM4 -178
CALM1 -169
MYL6 -156
TLN1 -86
CALD1 -18
VCL -11
MYL12B -4
ANXA1 46
TPM1 438

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TPM3 -394
ANXA2 -345
MYL9 -277
TPM4 -178
CALM1 -169
MYL6 -156
TLN1 -86
CALD1 -18
VCL -11
MYL12B -4
ANXA1 46
TPM1 438


Cell surface interactions at the vascular wall
set Cell surface interactions at the vascular wall
setSize 75
pANOVA 0.0659
s.dist -0.128
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGA6 -401
FYN -369
MERTK -367
IGKV1D-16 -348
IGKV3-20 -333
CD99 -315
PECAM1 -307
IGLV2-23 -290
IGLV4-60 -285
IGKC -284
IGLV3-16 -282
SRC -270
IGKV3D-20 -262
IGKV1-5 -260
ITGB1 -258
PF4 -252
IGLC2 -244
FCER1G -242
APOB -240
TGFB1 -225

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA6 -401
FYN -369
MERTK -367
IGKV1D-16 -348
IGKV3-20 -333
CD99 -315
PECAM1 -307
IGLV2-23 -290
IGLV4-60 -285
IGKC -284
IGLV3-16 -282
SRC -270
IGKV3D-20 -262
IGKV1-5 -260
ITGB1 -258
PF4 -252
IGLC2 -244
FCER1G -242
APOB -240
TGFB1 -225
IGKV1-16 -209
SELP -193
IGHV1-2 -186
F2 -177
IGLV2-18 -167
IGHV3-9 -165
PPIA -155
IGHA2 -154
IGKV1-17 -143
IGHM -131
JCHAIN -108
IGHA1 -101
ITGB3 -98
IGHV2-5 -94
SELL -64
IGHV3-30 -46
FN1 -25
F11R -22
IGHV2-70 -10
PROC 15
IGLL1 18
IGLV1-51 29
IGLV1-36 40
ITGB2 49
IGLV1-47 53
SIRPA 54
PROS1 63
IGKV4-1 80
IGLC7 81
SLC3A2 98
IGKV1D-33 111
IGKV3-11 113
IGLV2-14 116
IGLV2-11 122
IGHV1-69 131
IGLV4-3 134
IGLV6-57 144
IGHV4-34 146
IGHV3-23 186
IGHV3-7 205
L1CAM 271
IGHV3-13 285
IGLV1-40 300
IGLV1-44 308
PF4V1 309
IGLV8-61 336
GRB2 368
IGHV3-48 371
IGLV4-69 385
CD44 398
IGLV2-8 406
IGLV3-19 427
IGHV1-46 446
CD84 452
IGLV7-43 463


RHO GTPase cycle
set RHO GTPase cycle
setSize 38
pANOVA 0.0666
s.dist -0.176
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBN1 -399
TPM3 -394
CCT6A -339
FLOT2 -326
ARHGDIB -305
STIP1 -275
HSP90AB1 -271
SRC -270
ITGB1 -258
ROCK2 -256
BCAP31 -233
CCT2 -221
STOM -208
TPM4 -178
HSP90AA1 -123
ACTB -109
BASP1 -103
ACTN1 -96
VCP -83
PLXNB1 -80

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBN1 -399
TPM3 -394
CCT6A -339
FLOT2 -326
ARHGDIB -305
STIP1 -275
HSP90AB1 -271
SRC -270
ITGB1 -258
ROCK2 -256
BCAP31 -233
CCT2 -221
STOM -208
TPM4 -178
HSP90AA1 -123
ACTB -109
BASP1 -103
ACTN1 -96
VCP -83
PLXNB1 -80
SNAP23 -71
AKAP12 -70
TFRC -53
DSG2 -49
ACTC1 4
RAB7A 23
MCAM 37
HSPE1 152
CLTC 178
JUP 302
DSG1 303
RHOC 314
DSP 321
TXNL1 367
GRB2 368
IQGAP2 383
ARHGAP1 397
DIAPH1 460


ECM proteoglycans
set ECM proteoglycans
setSize 23
pANOVA 0.0674
s.dist -0.223
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
ITGA2 -361
LAMC1 -356
DAG1 -324
ITGB1 -258
TGFB1 -225
SPARC -170
TNC -140
ITGB3 -98
TNXB -76
COL6A1 -59
ITGA2B -52
VTN -26
FN1 -25
COMP -23
HSPG2 -15
LUM 8
LAMB1 28
LAMA2 34
NCAM1 43
APP 68

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGA2 -361
LAMC1 -356
DAG1 -324
ITGB1 -258
TGFB1 -225
SPARC -170
TNC -140
ITGB3 -98
TNXB -76
COL6A1 -59
ITGA2B -52
VTN -26
FN1 -25
COMP -23
HSPG2 -15
LUM 8
LAMB1 28
LAMA2 34
NCAM1 43
APP 68
COL6A3 216
SERPINE1 220
COL4A1 377


RHOH GTPase cycle
set RHOH GTPase cycle
setSize 8
pANOVA 0.0677
s.dist -0.375
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
DBN1 -399
ARHGDIB -305
ROCK2 -256
STOM -208
VCP -83
TFRC -53
RAB7A 23
JUP 302

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DBN1 -399
ARHGDIB -305
ROCK2 -256
STOM -208
VCP -83
TFRC -53
RAB7A 23
JUP 302


Response of endothelial cells to shear stress
set Response of endothelial cells to shear stress
setSize 16
pANOVA 0.0707
s.dist -0.263
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
FYN -369
ANXA2 -345
PECAM1 -307
FLT4 -261
ITGB1 -258
GNB2 -223
CALM1 -169
CAPNS1 -137
ITGB3 -98
TLN1 -86
FN1 -25
VCL -11
CDH5 27
PRKAR1A 335
GNAQ 366
GNB1 418

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FYN -369
ANXA2 -345
PECAM1 -307
FLT4 -261
ITGB1 -258
GNB2 -223
CALM1 -169
CAPNS1 -137
ITGB3 -98
TLN1 -86
FN1 -25
VCL -11
CDH5 27
PRKAR1A 335
GNAQ 366
GNB1 418


Metabolism of Angiotensinogen to Angiotensins
set Metabolism of Angiotensinogen to Angiotensins
setSize 7
pANOVA 0.0723
s.dist 0.394
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
CTSZ 481
AGT 346
CPB2 282
CTSD 252
ACE 166
ANPEP 140
CES1 -112

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CTSZ 481
AGT 346
CPB2 282
CTSD 252
ACE 166
ANPEP 140
CES1 -112


RHO GTPases activate PAKs
set RHO GTPases activate PAKs
setSize 7
pANOVA 0.0756
s.dist -0.389
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
MYL9 -277
CALM1 -169
MYL6 -156
CTTN -150
MYH9 -97
FLNA -51
MYL12B -4

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYL9 -277
CALM1 -169
MYL6 -156
CTTN -150
MYH9 -97
FLNA -51
MYL12B -4


Interaction between L1 and Ankyrins
set Interaction between L1 and Ankyrins
setSize 5
pANOVA 0.0762
s.dist 0.459
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
SPTB 391
SPTA1 374
ANK1 333
L1CAM 271
ACTB -109

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SPTB 391
SPTA1 374
ANK1 333
L1CAM 271
ACTB -109


Signaling by VEGF
set Signaling by VEGF
setSize 13
pANOVA 0.0772
s.dist -0.285
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
FYN -369
SRC -270
FLT4 -261
ROCK2 -256
CALM1 -169
HSPB1 -168
HSP90AA1 -123
ACTB -109
ITGB3 -98
CDH5 27
NRP2 179
NRP1 255
JUP 302

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FYN -369
SRC -270
FLT4 -261
ROCK2 -256
CALM1 -169
HSPB1 -168
HSP90AA1 -123
ACTB -109
ITGB3 -98
CDH5 27
NRP2 179
NRP1 255
JUP 302


Asparagine N-linked glycosylation
set Asparagine N-linked glycosylation
setSize 41
pANOVA 0.0799
s.dist 0.162
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
CTSZ 481
TUBA1C 478
B4GALT1 468
MLEC 466
ACTR1A 461
UGGT1 435
ARF4 433
ASGR2 421
ST6GALNAC1 407
MAN2A1 395
SPTB 391
SPTA1 374
PRKCSH 355
ANK1 333
ST6GAL1 325
RPS27A 305
GANAB 270
TUBB4B 230
TFG 214
SERPINA1 158

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CTSZ 481
TUBA1C 478
B4GALT1 468
MLEC 466
ACTR1A 461
UGGT1 435
ARF4 433
ASGR2 421
ST6GALNAC1 407
MAN2A1 395
SPTB 391
SPTA1 374
PRKCSH 355
ANK1 333
ST6GAL1 325
RPS27A 305
GANAB 270
TUBB4B 230
TFG 214
SERPINA1 158
MAN1A1 125
CTSC 72
CALR 64
LMAN2 59
TUBB1 22
RAB1B 14
PDIA3 -21
TUBA4A -57
FUCA1 -68
DYNC1H1 -73
VCP -83
F8 -144
TMED7 -173
F5 -220
HK1 -243
UMOD -274
ARF3 -279
RAB1A -289
CANX -352
TUBA8 -364
CAPZA1 -390


Lectin pathway of complement activation
set Lectin pathway of complement activation
setSize 8
pANOVA 0.08
s.dist 0.359
p.adjustANOVA 0.876


Top enriched genes
Top 20 genes
GeneID Gene Rank
COLEC10 364
MASP2 356
COLEC11 215
MASP1 199
MBL2 191
FCN1 145
FCN3 136
FCN2 45

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COLEC10 364
MASP2 356
COLEC11 215
MASP1 199
MBL2 191
FCN1 145
FCN3 136
FCN2 45


Network diagram

Only used for one-dimensional analysis.

Here, the network diagram is used to depict the similarity between some of the top ranked gene sets. It makes separate charts for up and downregulated sets. It works best when prioritisation is done by effect size during the mitch_calc() step. By default, we only show the top 20 genes, but you can use the networkplot() command yourself with other options. See ?networkplot for more detail. There is an element of stochasticity with regard to the network projection, so if you see a lot of overlapping labels or labels getting cut off, you could repeat the chart generation until you get a nice layout. See ?networkplot for more detail.

Below the network diagrams, you will see lists of genes that make up the up and downregulated sets respectively. For upregulated genes the score needs to be >2 and for downregulated genes it needs to be < -2. This is to remove genes that have uninteresting differential expression and do not contribute enrichment.

if (d==1) {
  networkplot(eres=res,FDR=0.05,n_sets=20)
  network_genes(eres=res,FDR=0.05,n_sets=20)
} else {
 message("Network charts only generated in one-dimensional analysis.")
}
## Can't plot upregulated sets. Fewer than 5 found.
## Can't plot downregulated sets. Fewer than 5 found.
## No significant upregulated sets to show.
## No significant upregulated sets to show.
## [[1]]
## NULL

Session information

Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.6.0 (2026-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] PLSDAbatch_2.0.0       kableExtra_1.4.0       gtools_3.9.5          
##  [4] beeswarm_0.4.0         eulerr_7.1.0           msigdbr_26.1.0        
##  [7] mitch_1.24.0           knitr_1.51             ReactomePA_1.56.0     
## [10] umap_0.2.10.0          org.Hs.eg.db_3.23.1    AnnotationDbi_1.74.0  
## [13] IRanges_2.46.0         S4Vectors_0.50.1       Biobase_2.72.0        
## [16] BiocGenerics_0.58.1    generics_0.1.4         clusterProfiler_4.20.0
## [19] pheatmap_1.0.13        limma_3.68.2           janitor_2.2.1         
## [22] lubridate_1.9.5        forcats_1.0.1          stringr_1.6.0         
## [25] purrr_1.2.2            readr_2.2.0            tidyr_1.3.2           
## [28] tibble_3.3.1           ggplot2_4.0.3          tidyverse_2.0.0       
## [31] dplyr_1.2.1            BiocManager_1.30.27   
## 
## loaded via a namespace (and not attached):
##   [1] matrixStats_1.5.0       fs_2.1.0                bitops_1.0-9           
##   [4] enrichplot_1.32.0       insight_1.5.0           httr_1.4.8             
##   [7] RColorBrewer_1.1-3      numDeriv_2016.8-1.1     tools_4.6.0            
##  [10] backports_1.5.1         utf8_1.2.6              R6_2.6.1               
##  [13] lazyeval_0.2.3          withr_3.0.2             graphite_1.58.0        
##  [16] GGally_2.4.0            gridExtra_2.3           performance_0.16.0     
##  [19] cli_3.6.6               textshaping_1.0.5       network_1.20.0         
##  [22] scatterpie_0.2.6        labeling_0.4.3          sass_0.4.10            
##  [25] S7_0.2.2                askpass_1.2.1           systemfonts_1.3.2      
##  [28] yulab.utils_0.2.4       gson_0.1.0              DOSE_4.6.0             
##  [31] svglite_2.2.2           dichromat_2.0-0.1       rstudioapi_0.18.0      
##  [34] RSQLite_3.52.0          gridGraphics_0.5-1      vroom_1.7.1            
##  [37] car_3.1-5               GO.db_3.23.1            Matrix_1.7-5           
##  [40] abind_1.4-8             lifecycle_1.0.5         yaml_2.3.12            
##  [43] snakecase_0.11.1        carData_3.0-6           gplots_3.3.0           
##  [46] qvalue_2.44.0           grid_4.6.0              blob_1.3.0             
##  [49] promises_1.5.0          crayon_1.5.3            ggtangle_0.1.2         
##  [52] lattice_0.22-9          echarts4r_0.5.0         KEGGREST_1.52.0        
##  [55] pillar_1.11.1           boot_1.3-32             corpcor_1.6.10         
##  [58] codetools_0.2-20        mixOmics_6.36.0         glue_1.8.1             
##  [61] ggiraph_0.9.6           ggfun_0.2.0             fontLiberation_0.1.0   
##  [64] vctrs_0.7.3             png_0.1-9               treeio_1.36.1          
##  [67] Rdpack_2.6.6            gtable_0.3.6            assertthat_0.2.1       
##  [70] cachem_1.1.0            xfun_0.57               rbibutils_2.4.1        
##  [73] mime_0.13               tidygraph_1.3.1         Seqinfo_1.2.0          
##  [76] reformulas_0.4.4        coda_0.19-4.1           aisdk_1.1.0            
##  [79] statmod_1.5.2           nlme_3.1-169            ggtree_4.2.0           
##  [82] bit64_4.8.0             fontquiver_0.2.1        bslib_0.11.0           
##  [85] KernSmooth_2.23-26      otel_0.2.0              DBI_1.3.0              
##  [88] tidyselect_1.2.1        processx_3.9.0          bit_4.6.0              
##  [91] compiler_4.6.0          curl_7.1.0              httr2_1.2.2            
##  [94] graph_1.90.0            xml2_1.5.2              fontBitstreamVera_0.1.1
##  [97] scales_1.4.0            caTools_1.18.3          callr_3.7.6            
## [100] rappdirs_0.3.4          digest_0.6.39           minqa_1.2.8            
## [103] rmarkdown_2.31          XVector_0.52.0          htmltools_0.5.9        
## [106] pkgconfig_2.0.3         lme4_2.0-1              fastmap_1.2.0          
## [109] rlang_1.2.0             htmlwidgets_1.6.4       shiny_1.13.0           
## [112] farver_2.1.2            jquerylib_0.1.4         jsonlite_2.0.0         
## [115] BiocParallel_1.46.0     statnet.common_4.13.0   GOSemSim_2.38.0        
## [118] magrittr_2.0.5          Formula_1.2-5           ggplotify_0.1.3        
## [121] patchwork_1.3.2         Rcpp_1.1.1-1.1          ape_5.8-1              
## [124] babelgene_22.9          ggnewscale_0.5.2        viridis_0.6.5          
## [127] gdtools_0.5.0           reticulate_1.46.0       stringi_1.8.7          
## [130] ggraph_2.2.2            MASS_7.3-65             plyr_1.8.9             
## [133] ggstats_0.13.0          parallel_4.6.0          ggrepel_0.9.8          
## [136] Biostrings_2.80.0       graphlayouts_1.2.3      splines_4.6.0          
## [139] hms_1.1.4               polylabelr_1.0.0        ps_1.9.3               
## [142] igraph_2.3.1            ggpubr_0.6.3            ggsignif_0.6.4         
## [145] enrichit_0.1.4          reshape2_1.4.5          evaluate_1.0.5         
## [148] nloptr_2.2.1            tzdb_0.5.0              tweenr_2.0.3           
## [151] httpuv_1.6.17           openssl_2.4.1           polyclip_1.10-7        
## [154] ggforce_0.5.0           broom_1.0.13            xtable_1.8-8           
## [157] reactome.db_1.96.0      RSpectra_0.16-2         tidytree_0.4.7         
## [160] tidydr_0.0.6            rstatix_0.7.3           later_1.4.8            
## [163] viridisLite_0.4.3       rARPACK_0.11-0          lmerTest_3.2-1         
## [166] aplot_0.2.9             ellipse_0.5.0           memoise_2.0.1          
## [169] cluster_2.1.8.2         timechange_0.4.0

END of report