date generated: 2020-12-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                       x
##           -1266.6248017
## 5_8S_rRNA   -15.7561510
## A1BG         -1.6154621
## A1CF          0.2527981
## A2M          -0.8454804
## A3GALT2       0.2338000

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genesets 2408
num_genes_in_profile 17707
duplicated_genes_present 0
num_profile_genes_in_sets 9310
num_profile_genes_not_in_sets 8397

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2408
num_genesets_excluded 962
num_genesets_included 1446

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set setSize pANOVA s.dist p.adjustANOVA
Mitochondrial translation elongation 85 6.41e-21 0.5880 7.06e-18
Mitochondrial translation 91 9.76e-21 0.5660 7.06e-18
Mitochondrial translation termination 85 3.68e-20 0.5770 1.77e-17
Translation 263 2.86e-19 0.3220 1.03e-16
Mitochondrial translation initiation 85 7.75e-19 0.5560 2.24e-16
The citric acid (TCA) cycle and respiratory electron transport 165 3.56e-13 0.3280 8.58e-11
Macroautophagy 108 3.98e-12 0.3860 8.22e-10
Autophagy 122 1.98e-11 0.3520 3.57e-09
Protein localization 156 4.45e-11 0.3060 7.14e-09
Metabolism of proteins 1810 1.06e-10 0.0924 1.53e-08
Defective CFTR causes cystic fibrosis 58 2.33e-09 0.4530 3.06e-07
ABC transporter disorders 74 3.62e-09 0.3970 4.36e-07
Metabolism 1943 4.82e-09 0.0812 5.36e-07
Respiratory electron transport 96 5.36e-09 0.3450 5.53e-07
Selective autophagy 56 1.25e-08 0.4400 1.20e-06
ABC-family proteins mediated transport 97 1.32e-08 0.3340 1.20e-06
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 53 2.63e-08 0.4420 2.24e-06
Hh mutants abrogate ligand secretion 56 3.10e-08 0.4280 2.49e-06
Interleukin-1 signaling 94 4.17e-08 0.3270 3.18e-06
tRNA Aminoacylation 42 5.94e-08 0.4830 4.24e-06
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 117 6.16e-08 0.2900 4.24e-06
AUF1 (hnRNP D0) binds and destabilizes mRNA 51 8.72e-08 0.4330 5.49e-06
Regulation of ornithine decarboxylase (ODC) 49 8.74e-08 0.4420 5.49e-06
NIK-->noncanonical NF-kB signaling 56 9.53e-08 0.4120 5.74e-06
Degradation of GLI2 by the proteasome 55 1.10e-07 0.4140 6.39e-06
Regulation of Apoptosis 50 1.34e-07 0.4310 7.20e-06
Pyruvate metabolism and Citric Acid (TCA) cycle 52 1.34e-07 0.4230 7.20e-06
Metabolism of polyamines 57 1.49e-07 0.4020 7.71e-06
Cross-presentation of soluble exogenous antigens (endosomes) 48 1.56e-07 0.4380 7.80e-06
Mitochondrial Fatty Acid Beta-Oxidation 36 1.69e-07 0.5040 8.09e-06
Vif-mediated degradation of APOBEC3G 50 1.80e-07 0.4270 8.09e-06
Degradation of GLI1 by the proteasome 56 1.80e-07 0.4030 8.09e-06
Vpu mediated degradation of CD4 49 1.85e-07 0.4310 8.09e-06
Mitochondrial protein import 62 1.99e-07 0.3820 8.45e-06
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 2.46e-07 0.4140 1.02e-05
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 63 2.79e-07 0.3740 1.12e-05
Regulation of activated PAK-2p34 by proteasome mediated degradation 47 2.88e-07 0.4330 1.13e-05
Deubiquitination 231 2.98e-07 0.1960 1.13e-05
Interleukin-1 family signaling 127 3.64e-07 0.2610 1.35e-05
GLI3 is processed to GLI3R by the proteasome 56 3.98e-07 0.3920 1.44e-05
SCF-beta-TrCP mediated degradation of Emi1 52 4.35e-07 0.4050 1.53e-05
Cell surface interactions at the vascular wall 155 4.47e-07 -0.2350 1.54e-05
Hedgehog ligand biogenesis 61 5.34e-07 0.3710 1.80e-05
Degradation of DVL 54 5.86e-07 0.3930 1.90e-05
Regulation of RUNX2 expression and activity 69 6.03e-07 0.3470 1.90e-05
Dectin-1 mediated noncanonical NF-kB signaling 59 6.05e-07 0.3760 1.90e-05
Cellular response to hypoxia 72 6.20e-07 0.3400 1.91e-05
Autodegradation of the E3 ubiquitin ligase COP1 47 6.40e-07 0.4200 1.93e-05
FCGR3A-mediated phagocytosis 87 7.68e-07 -0.3070 2.18e-05
Leishmania phagocytosis 87 7.68e-07 -0.3070 2.18e-05


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Mitochondrial translation elongation 85 6.41e-21 0.588000 7.06e-18
Mitochondrial translation 91 9.76e-21 0.566000 7.06e-18
Mitochondrial translation termination 85 3.68e-20 0.577000 1.77e-17
Translation 263 2.86e-19 0.322000 1.03e-16
Mitochondrial translation initiation 85 7.75e-19 0.556000 2.24e-16
The citric acid (TCA) cycle and respiratory electron transport 165 3.56e-13 0.328000 8.58e-11
Macroautophagy 108 3.98e-12 0.386000 8.22e-10
Autophagy 122 1.98e-11 0.352000 3.57e-09
Protein localization 156 4.45e-11 0.306000 7.14e-09
Metabolism of proteins 1810 1.06e-10 0.092400 1.53e-08
Defective CFTR causes cystic fibrosis 58 2.33e-09 0.453000 3.06e-07
ABC transporter disorders 74 3.62e-09 0.397000 4.36e-07
Metabolism 1943 4.82e-09 0.081200 5.36e-07
Respiratory electron transport 96 5.36e-09 0.345000 5.53e-07
Selective autophagy 56 1.25e-08 0.440000 1.20e-06
ABC-family proteins mediated transport 97 1.32e-08 0.334000 1.20e-06
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 53 2.63e-08 0.442000 2.24e-06
Hh mutants abrogate ligand secretion 56 3.10e-08 0.428000 2.49e-06
Interleukin-1 signaling 94 4.17e-08 0.327000 3.18e-06
tRNA Aminoacylation 42 5.94e-08 0.483000 4.24e-06
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 117 6.16e-08 0.290000 4.24e-06
AUF1 (hnRNP D0) binds and destabilizes mRNA 51 8.72e-08 0.433000 5.49e-06
Regulation of ornithine decarboxylase (ODC) 49 8.74e-08 0.442000 5.49e-06
NIK-->noncanonical NF-kB signaling 56 9.53e-08 0.412000 5.74e-06
Degradation of GLI2 by the proteasome 55 1.10e-07 0.414000 6.39e-06
Regulation of Apoptosis 50 1.34e-07 0.431000 7.20e-06
Pyruvate metabolism and Citric Acid (TCA) cycle 52 1.34e-07 0.423000 7.20e-06
Metabolism of polyamines 57 1.49e-07 0.402000 7.71e-06
Cross-presentation of soluble exogenous antigens (endosomes) 48 1.56e-07 0.438000 7.80e-06
Mitochondrial Fatty Acid Beta-Oxidation 36 1.69e-07 0.504000 8.09e-06
Vif-mediated degradation of APOBEC3G 50 1.80e-07 0.427000 8.09e-06
Degradation of GLI1 by the proteasome 56 1.80e-07 0.403000 8.09e-06
Vpu mediated degradation of CD4 49 1.85e-07 0.431000 8.09e-06
Mitochondrial protein import 62 1.99e-07 0.382000 8.45e-06
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 2.46e-07 0.414000 1.02e-05
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 63 2.79e-07 0.374000 1.12e-05
Regulation of activated PAK-2p34 by proteasome mediated degradation 47 2.88e-07 0.433000 1.13e-05
Deubiquitination 231 2.98e-07 0.196000 1.13e-05
Interleukin-1 family signaling 127 3.64e-07 0.261000 1.35e-05
GLI3 is processed to GLI3R by the proteasome 56 3.98e-07 0.392000 1.44e-05
SCF-beta-TrCP mediated degradation of Emi1 52 4.35e-07 0.405000 1.53e-05
Cell surface interactions at the vascular wall 155 4.47e-07 -0.235000 1.54e-05
Hedgehog ligand biogenesis 61 5.34e-07 0.371000 1.80e-05
Degradation of DVL 54 5.86e-07 0.393000 1.90e-05
Regulation of RUNX2 expression and activity 69 6.03e-07 0.347000 1.90e-05
Dectin-1 mediated noncanonical NF-kB signaling 59 6.05e-07 0.376000 1.90e-05
Cellular response to hypoxia 72 6.20e-07 0.340000 1.91e-05
Autodegradation of the E3 ubiquitin ligase COP1 47 6.40e-07 0.420000 1.93e-05
FCGR3A-mediated phagocytosis 87 7.68e-07 -0.307000 2.18e-05
Leishmania phagocytosis 87 7.68e-07 -0.307000 2.18e-05
Parasite infection 87 7.68e-07 -0.307000 2.18e-05
Degradation of AXIN 51 8.36e-07 0.399000 2.33e-05
HSP90 chaperone cycle for steroid hormone receptors (SHR) 35 8.53e-07 0.481000 2.33e-05
Neddylation 225 1.07e-06 0.189000 2.86e-05
Extracellular matrix organization 271 1.10e-06 -0.172000 2.88e-05
Regulation of actin dynamics for phagocytic cup formation 88 1.23e-06 -0.299000 3.16e-05
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 48 1.75e-06 0.399000 4.28e-05
p53-Independent DNA Damage Response 48 1.75e-06 0.399000 4.28e-05
p53-Independent G1/S DNA damage checkpoint 48 1.75e-06 0.399000 4.28e-05
Ubiquitin-dependent degradation of Cyclin D 49 1.84e-06 0.394000 4.43e-05
Negative regulation of NOTCH4 signaling 52 2.08e-06 0.380000 4.94e-05
Degradation of beta-catenin by the destruction complex 81 2.76e-06 0.301000 6.43e-05
Stabilization of p53 51 2.87e-06 0.379000 6.59e-05
Fcgamma receptor (FCGR) dependent phagocytosis 113 3.31e-06 -0.253000 7.48e-05
UCH proteinases 84 3.43e-06 0.293000 7.64e-05
Downstream TCR signaling 86 3.63e-06 0.289000 7.96e-05
Regulation of PTEN stability and activity 66 3.87e-06 0.329000 8.35e-05
Complex I biogenesis 53 6.84e-06 0.357000 1.45e-04
Ub-specific processing proteases 159 6.98e-06 0.207000 1.46e-04
Activation of NF-kappaB in B cells 62 9.21e-06 0.326000 1.88e-04
Asymmetric localization of PCP proteins 61 9.23e-06 0.328000 1.88e-04
Regulation of RUNX3 expression and activity 52 9.96e-06 0.354000 2.00e-04
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 131 1.26e-05 -0.221000 2.49e-04
HSF1-dependent transactivation 30 1.62e-05 0.455000 3.15e-04
MTOR signalling 38 1.63e-05 0.404000 3.15e-04
Signaling by GPCR 813 2.19e-05 -0.088000 4.16e-04
Membrane Trafficking 578 2.24e-05 0.104000 4.20e-04
PCP/CE pathway 89 2.84e-05 0.257000 5.26e-04
DNA Damage/Telomere Stress Induced Senescence 41 2.99e-05 -0.377000 5.48e-04
GPCR downstream signalling 746 3.32e-05 -0.089600 5.94e-04
Citric acid cycle (TCA cycle) 22 3.33e-05 0.511000 5.94e-04
Cellular responses to stress 474 3.74e-05 0.111000 6.60e-04
Mitochondrial biogenesis 87 4.08e-05 0.255000 7.11e-04
Signaling by Rho GTPases 373 4.31e-05 -0.124000 7.41e-04
Mitochondrial tRNA aminoacylation 21 5.05e-05 0.511000 8.59e-04
Late endosomal microautophagy 30 5.29e-05 0.426000 8.90e-04
Branched-chain amino acid catabolism 21 7.19e-05 0.500000 1.20e-03
Chromosome Maintenance 98 7.53e-05 -0.231000 1.24e-03
Gluconeogenesis 32 8.30e-05 0.402000 1.34e-03
Signaling by NOTCH4 78 8.42e-05 0.258000 1.34e-03
Autodegradation of Cdh1 by Cdh1:APC/C 61 8.45e-05 0.291000 1.34e-03
FCERI mediated Ca+2 mobilization 58 8.51e-05 -0.298000 1.34e-03
Antigen processing-Cross presentation 92 8.68e-05 0.237000 1.35e-03
MyD88-independent TLR4 cascade 87 9.05e-05 0.243000 1.38e-03
TRIF(TICAM1)-mediated TLR4 signaling 87 9.05e-05 0.243000 1.38e-03
TCR signaling 107 9.13e-05 0.219000 1.38e-03
CLEC7A (Dectin-1) signaling 94 9.72e-05 0.233000 1.44e-03
Cellular responses to external stimuli 481 9.79e-05 0.104000 1.44e-03
HIV Infection 219 1.09e-04 0.152000 1.58e-03
Cytosolic tRNA aminoacylation 24 1.10e-04 0.456000 1.58e-03
Activation of ATR in response to replication stress 36 1.13e-04 -0.372000 1.62e-03
COPI-mediated anterograde transport 78 1.29e-04 0.251000 1.83e-03
CDT1 association with the CDC6:ORC:origin complex 56 1.30e-04 0.296000 1.83e-03
PINK1-PRKN Mediated Mitophagy 19 1.35e-04 0.506000 1.88e-03
Antigen processing: Ubiquitination & Proteasome degradation 290 1.69e-04 0.129000 2.33e-03
Deposition of new CENPA-containing nucleosomes at the centromere 35 1.73e-04 -0.367000 2.33e-03
Nucleosome assembly 35 1.73e-04 -0.367000 2.33e-03
Toll Like Receptor 9 (TLR9) Cascade 84 1.74e-04 0.237000 2.33e-03
The role of GTSE1 in G2/M progression after G2 checkpoint 54 1.82e-04 0.294000 2.41e-03
Toll Like Receptor 3 (TLR3) Cascade 85 1.86e-04 0.235000 2.45e-03
Fatty acid metabolism 165 1.92e-04 0.168000 2.50e-03
Cholesterol biosynthesis 22 2.05e-04 -0.457000 2.63e-03
APC/C:Cdc20 mediated degradation of Securin 64 2.05e-04 0.268000 2.63e-03
Processing of DNA double-strand break ends 66 2.16e-04 -0.263000 2.74e-03
Xenobiotics 22 2.22e-04 -0.455000 2.79e-03
Glucose metabolism 88 2.40e-04 0.227000 2.99e-03
DNA Damage Recognition in GG-NER 37 2.93e-04 0.344000 3.59e-03
Class I MHC mediated antigen processing & presentation 345 2.93e-04 0.114000 3.59e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 2.95e-04 0.661000 3.59e-03
Glycogen metabolism 25 3.02e-04 0.417000 3.61e-03
Downstream signaling events of B Cell Receptor (BCR) 75 3.02e-04 0.241000 3.61e-03
Hemostasis 583 3.27e-04 -0.087300 3.88e-03
Mitophagy 26 3.37e-04 0.406000 3.96e-03
ER-Phagosome pathway 79 3.45e-04 0.233000 4.02e-03
Transcriptional regulation by RUNX2 115 3.67e-04 0.192000 4.25e-03
ER to Golgi Anterograde Transport 127 4.16e-04 0.181000 4.78e-03
Leishmania infection 255 4.24e-04 -0.128000 4.83e-03
Peroxisomal protein import 60 4.31e-04 0.263000 4.87e-03
Metabolism of cofactors 18 4.55e-04 0.477000 5.10e-03
MyD88 dependent cascade initiated on endosome 80 4.61e-04 0.227000 5.13e-03
Disorders of transmembrane transporters 169 5.04e-04 0.155000 5.56e-03
Metabolism of amino acids and derivatives 335 5.21e-04 0.110000 5.71e-03
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 79 5.66e-04 0.224000 6.11e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs 77 5.67e-04 0.227000 6.11e-03
FCGR activation 42 5.76e-04 -0.307000 6.17e-03
MyD88 cascade initiated on plasma membrane 76 6.35e-04 0.227000 6.66e-03
Toll Like Receptor 10 (TLR10) Cascade 76 6.35e-04 0.227000 6.66e-03
Toll Like Receptor 5 (TLR5) Cascade 76 6.35e-04 0.227000 6.66e-03
Formation of TC-NER Pre-Incision Complex 50 7.05e-04 0.277000 7.33e-03
Scavenging of heme from plasma 41 7.10e-04 -0.306000 7.34e-03
Toll Like Receptor 7/8 (TLR7/8) Cascade 81 7.18e-04 0.217000 7.35e-03
Regulation of Complement cascade 71 7.21e-04 -0.232000 7.35e-03
Hedgehog 'off' state 95 7.60e-04 0.200000 7.69e-03
Aggrephagy 20 7.83e-04 0.434000 7.86e-03
Assembly of collagen fibrils and other multimeric structures 50 7.95e-04 -0.274000 7.93e-03
Mitochondrial calcium ion transport 22 8.08e-04 0.413000 8.00e-03
COPI-independent Golgi-to-ER retrograde traffic 33 8.54e-04 0.335000 8.39e-03
Asparagine N-linked glycosylation 268 8.59e-04 0.118000 8.39e-03
Host Interactions of HIV factors 123 8.80e-04 0.174000 8.54e-03
Energy dependent regulation of mTOR by LKB1-AMPK 28 9.67e-04 0.360000 9.31e-03
Cellular response to heat stress 92 9.72e-04 0.199000 9.31e-03
IRE1alpha activates chaperones 50 1.01e-03 0.269000 9.62e-03
p53-Dependent G1 DNA Damage Response 60 1.02e-03 0.245000 9.62e-03
p53-Dependent G1/S DNA damage checkpoint 60 1.02e-03 0.245000 9.62e-03
Role of phospholipids in phagocytosis 55 1.05e-03 -0.255000 9.80e-03
SCF(Skp2)-mediated degradation of p27/p21 58 1.12e-03 0.247000 1.04e-02
PTEN Regulation 145 1.13e-03 0.157000 1.04e-02
Presynaptic phase of homologous DNA pairing and strand exchange 38 1.13e-03 -0.305000 1.04e-02
Peroxisomal lipid metabolism 27 1.15e-03 0.361000 1.04e-02
Keratinization 92 1.15e-03 -0.196000 1.04e-02
Meiosis 67 1.20e-03 -0.229000 1.08e-02
Vesicle-mediated transport 642 1.21e-03 0.075100 1.08e-02
XBP1(S) activates chaperone genes 48 1.22e-03 0.270000 1.08e-02
mTORC1-mediated signalling 22 1.22e-03 0.398000 1.08e-02
FCGR3A-mediated IL10 synthesis 67 1.24e-03 -0.228000 1.09e-02
EPHB-mediated forward signaling 33 1.31e-03 -0.323000 1.13e-02
Common Pathway of Fibrin Clot Formation 18 1.31e-03 -0.437000 1.13e-02
MAPK6/MAPK4 signaling 84 1.32e-03 0.203000 1.13e-02
G1/S DNA Damage Checkpoints 61 1.32e-03 0.238000 1.13e-02
Pyruvate metabolism 28 1.37e-03 0.349000 1.17e-02
CDK-mediated phosphorylation and removal of Cdc6 69 1.46e-03 0.222000 1.24e-02
Degradation of the extracellular matrix 101 1.52e-03 -0.183000 1.27e-02
Regulation of expression of SLITs and ROBOs 144 1.52e-03 0.153000 1.27e-02
G2/M DNA damage checkpoint 64 1.53e-03 -0.229000 1.28e-02
Reproduction 88 1.54e-03 -0.195000 1.28e-02
Collagen chain trimerization 35 1.61e-03 -0.308000 1.32e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 59 1.61e-03 -0.237000 1.32e-02
Rho GTPase cycle 134 1.66e-03 -0.157000 1.35e-02
Formation of Fibrin Clot (Clotting Cascade) 35 1.68e-03 -0.307000 1.36e-02
Cell Cycle 607 1.70e-03 -0.074800 1.37e-02
Transcriptional regulation by RUNX3 88 1.73e-03 0.193000 1.38e-02
Activation of the pre-replicative complex 32 1.77e-03 -0.319000 1.41e-02
TNFR2 non-canonical NF-kB pathway 94 1.78e-03 0.187000 1.41e-02
Attenuation phase 21 1.84e-03 0.393000 1.44e-02
TP53 Regulates Metabolic Genes 84 1.88e-03 0.196000 1.47e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 33 1.95e-03 0.312000 1.51e-02
MAP kinase activation 60 1.96e-03 0.231000 1.51e-02
Role of LAT2/NTAL/LAB on calcium mobilization 43 1.96e-03 -0.273000 1.51e-02
Resolution of Sister Chromatid Cohesion 103 2.00e-03 -0.176000 1.53e-02
Cytosolic sensors of pathogen-associated DNA 55 2.06e-03 0.240000 1.57e-02
Metabolism of steroids 134 2.10e-03 -0.154000 1.59e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 70 2.13e-03 0.212000 1.60e-02
Cytochrome P450 - arranged by substrate type 60 2.14e-03 -0.229000 1.60e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 2.20e-03 0.559000 1.64e-02
Cristae formation 27 2.29e-03 0.339000 1.70e-02
Hedgehog 'on' state 82 2.40e-03 0.194000 1.77e-02
Regulation of RAS by GAPs 65 2.41e-03 0.218000 1.77e-02
RHO GTPase Effectors 249 2.47e-03 -0.112000 1.80e-02
Activation of the phototransduction cascade 11 2.49e-03 -0.527000 1.80e-02
rRNA processing in the mitochondrion 21 2.49e-03 0.381000 1.80e-02
Collagen formation 80 2.57e-03 -0.195000 1.85e-02
Mitotic Prometaphase 182 2.70e-03 -0.129000 1.94e-02
Fatty acids 14 2.73e-03 -0.463000 1.95e-02
Josephin domain DUBs 10 2.78e-03 0.546000 1.97e-02
Glycogen synthesis 14 2.83e-03 0.461000 2.00e-02
MHC class II antigen presentation 94 2.90e-03 0.178000 2.03e-02
Meiotic recombination 37 2.91e-03 -0.283000 2.03e-02
G alpha (i) signalling events 347 2.96e-03 -0.093000 2.06e-02
Cyclin A:Cdk2-associated events at S phase entry 83 3.01e-03 0.188000 2.08e-02
HSF1 activation 24 3.08e-03 0.349000 2.11e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 74 3.09e-03 0.199000 2.11e-02
Complement cascade 79 3.21e-03 -0.192000 2.19e-02
Carnitine metabolism 11 3.31e-03 0.511000 2.25e-02
Cyclin E associated events during G1/S transition 81 3.47e-03 0.188000 2.35e-02
Collagen biosynthesis and modifying enzymes 58 3.60e-03 -0.221000 2.42e-02
Crosslinking of collagen fibrils 10 3.62e-03 -0.531000 2.42e-02
N-Glycan antennae elongation 14 3.64e-03 -0.449000 2.43e-02
Visual phototransduction 93 3.82e-03 -0.174000 2.53e-02
Post-translational modification: synthesis of GPI-anchored proteins 82 3.87e-03 -0.185000 2.54e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 98 3.87e-03 -0.169000 2.54e-02
Beta-oxidation of very long chain fatty acids 10 4.29e-03 0.522000 2.80e-02
Telomere C-strand (Lagging Strand) Synthesis 33 4.29e-03 -0.287000 2.80e-02
Signaling by ROBO receptors 189 4.36e-03 0.120000 2.83e-02
Mitochondrial iron-sulfur cluster biogenesis 11 4.48e-03 0.495000 2.89e-02
Ovarian tumor domain proteases 35 4.75e-03 0.276000 3.05e-02
Apoptosis 162 4.95e-03 0.128000 3.16e-02
FCERI mediated MAPK activation 59 4.96e-03 -0.212000 3.16e-02
Homology Directed Repair 104 5.00e-03 -0.159000 3.17e-02
Interleukin-17 signaling 68 5.33e-03 0.195000 3.37e-02
Recycling of bile acids and salts 16 5.37e-03 -0.402000 3.37e-02
Programmed Cell Death 172 5.62e-03 0.122000 3.52e-02
Homologous DNA Pairing and Strand Exchange 41 5.70e-03 -0.250000 3.55e-02
trans-Golgi Network Vesicle Budding 70 5.80e-03 0.191000 3.60e-02
G alpha (q) signalling events 198 5.91e-03 -0.114000 3.64e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 5.92e-03 -0.188000 3.64e-02
Classical antibody-mediated complement activation 35 6.00e-03 -0.268000 3.68e-02
RHO GTPases Activate WASPs and WAVEs 35 6.04e-03 -0.268000 3.68e-02
Constitutive Signaling by Aberrant PI3K in Cancer 71 6.07e-03 -0.188000 3.69e-02
Glycolysis 68 6.12e-03 0.192000 3.70e-02
RHO GTPases Activate Formins 118 6.19e-03 -0.146000 3.72e-02
Transcriptional activation of mitochondrial biogenesis 53 6.21e-03 0.217000 3.72e-02
Glycogen storage diseases 14 6.24e-03 0.422000 3.72e-02
CD28 dependent Vav1 pathway 12 6.25e-03 -0.456000 3.72e-02
Regulation of innate immune responses to cytosolic DNA 13 6.58e-03 0.435000 3.90e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 69 6.61e-03 0.189000 3.90e-02
HDR through Single Strand Annealing (SSA) 37 6.71e-03 -0.258000 3.94e-02
GPCR ligand binding 390 6.73e-03 -0.080100 3.94e-02
KSRP (KHSRP) binds and destabilizes mRNA 17 7.00e-03 -0.378000 4.08e-02
Transcriptional regulation by RUNX1 185 7.25e-03 0.115000 4.21e-02
Miscellaneous substrates 12 7.35e-03 -0.447000 4.25e-02
Assembly of the pre-replicative complex 65 7.65e-03 0.191000 4.41e-02
Processing of SMDT1 15 7.83e-03 0.397000 4.49e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 7.89e-03 -0.301000 4.51e-02
Inositol phosphate metabolism 47 7.95e-03 0.224000 4.53e-02
CD22 mediated BCR regulation 34 8.08e-03 -0.263000 4.58e-02
Extension of Telomeres 50 8.14e-03 -0.216000 4.60e-02
Signaling by Hedgehog 131 8.34e-03 0.134000 4.69e-02
Mitotic Spindle Checkpoint 107 8.71e-03 -0.147000 4.88e-02
G alpha (12/13) signalling events 77 8.89e-03 -0.173000 4.96e-02
Cyclin A/B1/B2 associated events during G2/M transition 23 9.01e-03 -0.315000 5.01e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 86 9.23e-03 0.162000 5.06e-02
Toll Like Receptor 2 (TLR2) Cascade 86 9.23e-03 0.162000 5.06e-02
Toll Like Receptor TLR1:TLR2 Cascade 86 9.23e-03 0.162000 5.06e-02
Toll Like Receptor TLR6:TLR2 Cascade 86 9.23e-03 0.162000 5.06e-02
Cell Cycle Checkpoints 251 9.47e-03 -0.095200 5.17e-02
Elastic fibre formation 38 9.66e-03 -0.243000 5.25e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 9.97e-03 -0.156000 5.38e-02
Amplification of signal from the kinetochores 91 9.97e-03 -0.156000 5.38e-02
NRAGE signals death through JNK 56 1.00e-02 -0.199000 5.40e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 70 1.01e-02 0.178000 5.41e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 117 1.03e-02 -0.137000 5.50e-02
Polymerase switching on the C-strand of the telomere 25 1.04e-02 -0.296000 5.51e-02
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 23 1.06e-02 0.308000 5.62e-02
Condensation of Prophase Chromosomes 24 1.08e-02 -0.301000 5.68e-02
RNA Polymerase III Chain Elongation 14 1.09e-02 0.393000 5.73e-02
Post-translational protein phosphorylation 103 1.12e-02 -0.145000 5.87e-02
Orc1 removal from chromatin 68 1.15e-02 0.177000 6.00e-02
Role of second messengers in netrin-1 signaling 10 1.16e-02 -0.461000 6.05e-02
DNA strand elongation 31 1.17e-02 -0.262000 6.06e-02
Glycosphingolipid metabolism 40 1.17e-02 0.230000 6.06e-02
Signaling by Retinoic Acid 38 1.18e-02 0.236000 6.07e-02
VLDLR internalisation and degradation 12 1.18e-02 0.420000 6.07e-02
Signal Transduction 2291 1.21e-02 -0.032500 6.16e-02
Netrin-1 signaling 49 1.21e-02 -0.207000 6.17e-02
Chaperone Mediated Autophagy 18 1.22e-02 0.341000 6.20e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 29 1.23e-02 0.269000 6.23e-02
Iron uptake and transport 54 1.28e-02 0.196000 6.45e-02
Toll-like Receptor Cascades 138 1.28e-02 0.123000 6.45e-02
Post-translational protein modification 1269 1.29e-02 0.041800 6.47e-02
EML4 and NUDC in mitotic spindle formation 95 1.33e-02 -0.147000 6.62e-02
HDR through Homologous Recombination (HRR) 63 1.35e-02 -0.180000 6.70e-02
Regulation of APC/C activators between G1/S and early anaphase 77 1.35e-02 0.163000 6.70e-02
Eicosanoids 12 1.38e-02 -0.410000 6.81e-02
Toll Like Receptor 4 (TLR4) Cascade 114 1.39e-02 0.133000 6.81e-02
Rab regulation of trafficking 117 1.39e-02 0.132000 6.81e-02
Dectin-2 family 19 1.39e-02 -0.326000 6.81e-02
Binding and Uptake of Ligands by Scavenger Receptors 66 1.40e-02 -0.175000 6.82e-02
Cleavage of the damaged pyrimidine 25 1.49e-02 -0.281000 7.19e-02
Depyrimidination 25 1.49e-02 -0.281000 7.19e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 25 1.49e-02 -0.281000 7.19e-02
Cell Cycle, Mitotic 484 1.56e-02 -0.064300 7.51e-02
Anti-inflammatory response favouring Leishmania parasite infection 176 1.60e-02 -0.105000 7.63e-02
Leishmania parasite growth and survival 176 1.60e-02 -0.105000 7.63e-02
Base-Excision Repair, AP Site Formation 27 1.62e-02 -0.267000 7.73e-02
Diseases associated with O-glycosylation of proteins 60 1.65e-02 -0.179000 7.82e-02
Regulation of HSF1-mediated heat shock response 76 1.67e-02 0.159000 7.91e-02
N-glycan antennae elongation in the medial/trans-Golgi 23 1.71e-02 -0.287000 8.07e-02
Pexophagy 10 1.72e-02 0.435000 8.07e-02
TRAF6 mediated NF-kB activation 19 1.72e-02 0.316000 8.07e-02
Regulation of pyruvate dehydrogenase (PDH) complex 15 1.74e-02 0.355000 8.10e-02
Nucleotide Excision Repair 106 1.76e-02 0.134000 8.16e-02
Mitotic Telophase/Cytokinesis 13 1.76e-02 -0.380000 8.16e-02
FCERI mediated NF-kB activation 102 1.82e-02 0.135000 8.41e-02
Acetylcholine Neurotransmitter Release Cycle 15 1.89e-02 0.350000 8.68e-02
DARPP-32 events 23 1.96e-02 0.281000 9.01e-02
DAP12 interactions 38 1.99e-02 -0.218000 9.09e-02
Amino acids regulate mTORC1 50 2.00e-02 0.190000 9.09e-02
Ca2+ pathway 61 2.00e-02 -0.172000 9.09e-02
RNA Polymerase I Transcription Termination 28 2.01e-02 0.254000 9.10e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter 24 2.02e-02 0.274000 9.10e-02
Creation of C4 and C2 activators 41 2.02e-02 -0.210000 9.10e-02
Metabolism of fat-soluble vitamins 43 2.05e-02 -0.204000 9.21e-02
PI Metabolism 81 2.06e-02 0.149000 9.21e-02
Resolution of D-Loop Structures 33 2.10e-02 -0.232000 9.35e-02
G0 and Early G1 27 2.12e-02 -0.256000 9.43e-02
C-type lectin receptors (CLRs) 125 2.16e-02 0.119000 9.59e-02
RNA Polymerase I Transcription Initiation 44 2.25e-02 0.199000 9.94e-02
Transport of organic anions 12 2.30e-02 -0.379000 1.01e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 72 2.32e-02 0.155000 1.02e-01
Calnexin/calreticulin cycle 24 2.36e-02 0.267000 1.04e-01
Class I peroxisomal membrane protein import 18 2.41e-02 0.307000 1.05e-01
Telomere Maintenance 73 2.44e-02 -0.152000 1.06e-01
Intrinsic Pathway of Fibrin Clot Formation 22 2.46e-02 -0.277000 1.07e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 53 2.47e-02 -0.178000 1.07e-01
Striated Muscle Contraction 34 2.48e-02 0.223000 1.07e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 17 2.52e-02 0.314000 1.08e-01
Packaging Of Telomere Ends 16 2.52e-02 -0.323000 1.08e-01
Meiotic synapsis 41 2.55e-02 -0.202000 1.09e-01
Interleukin-6 signaling 11 2.57e-02 0.389000 1.09e-01
Regulation of IFNA signaling 24 2.59e-02 -0.263000 1.10e-01
Interleukin-20 family signaling 20 2.65e-02 0.287000 1.12e-01
Unfolded Protein Response (UPR) 91 2.66e-02 0.135000 1.12e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 2.69e-02 0.256000 1.12e-01
Cleavage of the damaged purine 20 2.69e-02 -0.286000 1.12e-01
Depurination 20 2.69e-02 -0.286000 1.12e-01
Recognition and association of DNA glycosylase with site containing an affected purine 20 2.69e-02 -0.286000 1.12e-01
E2F mediated regulation of DNA replication 21 2.69e-02 -0.279000 1.12e-01
Glyoxylate metabolism and glycine degradation 29 2.72e-02 0.237000 1.13e-01
Glycogen breakdown (glycogenolysis) 14 2.78e-02 0.340000 1.15e-01
Prolactin receptor signaling 12 2.80e-02 0.366000 1.16e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 2.86e-02 0.351000 1.18e-01
NCAM1 interactions 31 2.93e-02 -0.226000 1.20e-01
Interleukin-27 signaling 11 3.04e-02 0.377000 1.24e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 85 3.06e-02 0.136000 1.24e-01
Rap1 signalling 14 3.06e-02 0.334000 1.24e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 12 3.06e-02 0.360000 1.24e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 3.11e-02 0.345000 1.26e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 23 3.20e-02 0.258000 1.29e-01
Glycosaminoglycan metabolism 117 3.23e-02 -0.115000 1.30e-01
SARS-CoV-1 Infection 47 3.24e-02 0.180000 1.30e-01
CDC6 association with the ORC:origin complex 11 3.30e-02 -0.371000 1.32e-01
VEGFR2 mediated cell proliferation 19 3.30e-02 -0.283000 1.32e-01
Transcriptional regulation of granulopoiesis 40 3.33e-02 -0.195000 1.33e-01
TGF-beta receptor signaling activates SMADs 30 3.40e-02 0.224000 1.35e-01
Class A/1 (Rhodopsin-like receptors) 274 3.42e-02 -0.074400 1.36e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 15 3.45e-02 0.315000 1.36e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 3.45e-02 -0.326000 1.36e-01
Syndecan interactions 19 3.46e-02 -0.280000 1.36e-01
DNA Double-Strand Break Repair 131 3.47e-02 -0.107000 1.36e-01
Diseases associated with glycosylation precursor biosynthesis 18 3.48e-02 0.287000 1.36e-01
Diseases of signal transduction by growth factor receptors and second messengers 364 3.51e-02 0.064400 1.37e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 12 3.53e-02 -0.351000 1.37e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 3.55e-02 0.172000 1.37e-01
Signaling by Interleukins 404 3.55e-02 0.061100 1.37e-01
WNT ligand biogenesis and trafficking 25 3.55e-02 -0.243000 1.37e-01
Retrograde neurotrophin signalling 14 3.59e-02 0.324000 1.38e-01
Interleukin-10 signaling 38 3.60e-02 -0.197000 1.38e-01
mRNA 3'-end processing 55 3.61e-02 -0.163000 1.38e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 73 3.63e-02 0.142000 1.38e-01
Transport to the Golgi and subsequent modification 155 3.65e-02 0.097400 1.39e-01
Golgi Associated Vesicle Biogenesis 54 3.66e-02 0.164000 1.39e-01
Physiological factors 12 3.67e-02 0.348000 1.39e-01
Surfactant metabolism 24 3.68e-02 0.246000 1.39e-01
Base Excision Repair 54 3.71e-02 -0.164000 1.40e-01
TNF signaling 43 3.77e-02 0.183000 1.42e-01
activated TAK1 mediates p38 MAPK activation 18 3.78e-02 0.283000 1.42e-01
Dissolution of Fibrin Clot 12 3.82e-02 -0.346000 1.43e-01
Establishment of Sister Chromatid Cohesion 11 3.87e-02 -0.360000 1.44e-01
G beta:gamma signalling through CDC42 20 3.88e-02 -0.267000 1.44e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 27 3.91e-02 0.229000 1.45e-01
FLT3 Signaling 278 3.91e-02 0.072000 1.45e-01
Regulation of TP53 Activity through Phosphorylation 84 3.93e-02 -0.130000 1.45e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 14 3.95e-02 -0.318000 1.45e-01
Synthesis of PIPs at the plasma membrane 51 3.99e-02 0.166000 1.46e-01
Phospholipid metabolism 204 4.00e-02 0.083500 1.46e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 4.03e-02 -0.209000 1.47e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 4.20e-02 -0.285000 1.53e-01
Condensation of Prometaphase Chromosomes 10 4.31e-02 -0.369000 1.56e-01
Activation of gene expression by SREBF (SREBP) 41 4.32e-02 -0.183000 1.56e-01
Transport of Mature Transcript to Cytoplasm 80 4.32e-02 -0.131000 1.56e-01
Post NMDA receptor activation events 59 4.33e-02 0.152000 1.56e-01
Interferon gamma signaling 78 4.45e-02 0.132000 1.60e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 20 4.49e-02 0.259000 1.61e-01
Initial triggering of complement 48 4.51e-02 -0.167000 1.62e-01
Senescence-Associated Secretory Phenotype (SASP) 56 4.55e-02 -0.155000 1.62e-01
G alpha (s) signalling events 246 4.60e-02 -0.074000 1.64e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 14 4.66e-02 0.307000 1.66e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 11 4.75e-02 -0.345000 1.68e-01
Golgi-to-ER retrograde transport 112 4.76e-02 0.108000 1.68e-01
TICAM1-dependent activation of IRF3/IRF7 10 4.84e-02 0.360000 1.71e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 21 4.90e-02 -0.248000 1.72e-01
Downregulation of TGF-beta receptor signaling 25 4.91e-02 0.227000 1.72e-01
Erythrocytes take up carbon dioxide and release oxygen 11 5.00e-02 0.341000 1.74e-01
O2/CO2 exchange in erythrocytes 11 5.00e-02 0.341000 1.74e-01
Transport of small molecules 680 5.03e-02 0.044200 1.75e-01
Metabolism of RNA 630 5.07e-02 0.045800 1.76e-01
DAP12 signaling 29 5.08e-02 -0.210000 1.76e-01
Telomere C-strand synthesis initiation 13 5.15e-02 -0.312000 1.78e-01
Retinoid metabolism and transport 39 5.16e-02 -0.180000 1.78e-01
Beta-catenin independent WNT signaling 142 5.18e-02 0.094600 1.78e-01
Biological oxidations 178 5.21e-02 -0.084500 1.79e-01
Switching of origins to a post-replicative state 87 5.23e-02 0.120000 1.79e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 177 5.31e-02 0.084400 1.82e-01
TNFs bind their physiological receptors 26 5.36e-02 -0.219000 1.82e-01
Lysosome Vesicle Biogenesis 34 5.37e-02 0.191000 1.82e-01
Unwinding of DNA 12 5.37e-02 -0.322000 1.82e-01
Cellular Senescence 136 5.43e-02 -0.095700 1.84e-01
Chylomicron remodeling 10 5.62e-02 -0.349000 1.90e-01
Interleukin-35 Signalling 11 5.67e-02 0.332000 1.91e-01
ATF6 (ATF6-alpha) activates chaperones 12 5.80e-02 0.316000 1.95e-01
The phototransduction cascade 32 5.91e-02 -0.193000 1.98e-01
Cell death signalling via NRAGE, NRIF and NADE 72 5.93e-02 -0.129000 1.98e-01
Metabolism of lipids 693 5.95e-02 0.042200 1.99e-01
DNA Replication Pre-Initiation 81 5.98e-02 0.121000 1.99e-01
G beta:gamma signalling through BTK 18 6.01e-02 -0.256000 2.00e-01
Global Genome Nucleotide Excision Repair (GG-NER) 82 6.02e-02 0.120000 2.00e-01
tRNA processing 118 6.11e-02 0.099900 2.02e-01
tRNA processing in the mitochondrion 18 6.13e-02 0.255000 2.02e-01
Receptor Mediated Mitophagy 11 6.16e-02 0.325000 2.03e-01
Metabolism of carbohydrates 275 6.20e-02 0.065500 2.04e-01
RMTs methylate histone arginines 36 6.22e-02 0.180000 2.04e-01
mRNA decay by 3' to 5' exoribonuclease 16 6.25e-02 -0.269000 2.05e-01
Non-integrin membrane-ECM interactions 41 6.36e-02 -0.167000 2.08e-01
Budding and maturation of HIV virion 25 6.38e-02 0.214000 2.08e-01
Negative regulators of DDX58/IFIH1 signaling 31 6.48e-02 0.192000 2.10e-01
Signaling by NOTCH 183 6.49e-02 0.079200 2.10e-01
RAF/MAP kinase cascade 264 6.50e-02 0.066100 2.10e-01
MAPK1/MAPK3 signaling 270 6.55e-02 0.065200 2.11e-01
G-protein beta:gamma signalling 32 6.65e-02 -0.187000 2.14e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 24 6.75e-02 0.216000 2.17e-01
RNA Pol II CTD phosphorylation and interaction with CE 25 7.01e-02 0.209000 2.24e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 25 7.01e-02 0.209000 2.24e-01
ER Quality Control Compartment (ERQC) 19 7.03e-02 0.240000 2.24e-01
TCF dependent signaling in response to WNT 176 7.18e-02 0.078700 2.29e-01
Signaling by cytosolic FGFR1 fusion mutants 17 7.26e-02 0.252000 2.30e-01
CLEC7A (Dectin-1) induces NFAT activation 11 7.28e-02 -0.312000 2.30e-01
Biotin transport and metabolism 11 7.29e-02 0.312000 2.30e-01
PIP3 activates AKT signaling 265 7.31e-02 0.064000 2.30e-01
Potassium Channels 100 7.32e-02 -0.104000 2.30e-01
Chondroitin sulfate biosynthesis 20 7.33e-02 -0.231000 2.30e-01
Inactivation, recovery and regulation of the phototransduction cascade 31 7.41e-02 -0.185000 2.32e-01
Metabolism of nucleotides 94 7.51e-02 0.106000 2.35e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 20 7.61e-02 0.229000 2.37e-01
FOXO-mediated transcription of cell death genes 14 7.61e-02 0.274000 2.37e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 20 7.68e-02 -0.229000 2.38e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 20 7.68e-02 -0.229000 2.38e-01
Presynaptic depolarization and calcium channel opening 12 7.70e-02 -0.295000 2.38e-01
Processive synthesis on the C-strand of the telomere 18 7.77e-02 -0.240000 2.40e-01
DSCAM interactions 11 7.83e-02 -0.307000 2.41e-01
Defective GALNT12 causes colorectal cancer 1 (CRCS1) 10 7.90e-02 -0.321000 2.43e-01
Dual incision in TC-NER 61 7.99e-02 0.130000 2.44e-01
APC/C-mediated degradation of cell cycle proteins 84 7.99e-02 0.111000 2.44e-01
Regulation of mitotic cell cycle 84 7.99e-02 0.111000 2.44e-01
Glutamate and glutamine metabolism 13 8.02e-02 0.280000 2.45e-01
RHO GTPases activate CIT 19 8.06e-02 -0.232000 2.45e-01
Regulation of insulin secretion 75 8.14e-02 -0.116000 2.47e-01
Platelet sensitization by LDL 16 8.16e-02 0.251000 2.47e-01
Phase I - Functionalization of compounds 93 8.17e-02 -0.104000 2.47e-01
Interleukin-6 family signaling 24 8.20e-02 0.205000 2.47e-01
Extra-nuclear estrogen signaling 72 8.24e-02 -0.118000 2.48e-01
Cytosolic iron-sulfur cluster assembly 13 8.26e-02 0.278000 2.48e-01
RAF activation 33 8.27e-02 0.175000 2.48e-01
Transport of bile salts and organic acids, metal ions and amine compounds 78 8.31e-02 -0.114000 2.48e-01
Purine ribonucleoside monophosphate biosynthesis 10 8.32e-02 0.316000 2.48e-01
Signaling by TGFB family members 96 8.32e-02 0.102000 2.48e-01
Association of TriC/CCT with target proteins during biosynthesis 38 8.40e-02 0.162000 2.49e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 8.40e-02 0.288000 2.49e-01
alpha-linolenic acid (ALA) metabolism 12 8.40e-02 0.288000 2.49e-01
PRC2 methylates histones and DNA 23 8.43e-02 -0.208000 2.49e-01
Synthesis of substrates in N-glycan biosythesis 60 8.54e-02 0.128000 2.52e-01
Transferrin endocytosis and recycling 29 8.60e-02 0.184000 2.53e-01
Defects in vitamin and cofactor metabolism 22 8.61e-02 0.211000 2.53e-01
PIWI-interacting RNA (piRNA) biogenesis 25 8.64e-02 0.198000 2.53e-01
Plasma lipoprotein remodeling 31 8.70e-02 -0.178000 2.55e-01
Aflatoxin activation and detoxification 18 8.71e-02 -0.233000 2.55e-01
Leading Strand Synthesis 13 8.79e-02 -0.273000 2.56e-01
Polymerase switching 13 8.79e-02 -0.273000 2.56e-01
RNA Polymerase II Transcription Termination 63 8.83e-02 -0.124000 2.56e-01
Ras activation upon Ca2+ influx through NMDA receptor 19 8.85e-02 0.226000 2.57e-01
Nucleotide salvage 22 8.99e-02 0.209000 2.60e-01
O-linked glycosylation 100 9.01e-02 -0.098100 2.60e-01
Class B/2 (Secretin family receptors) 86 9.02e-02 -0.106000 2.60e-01
Signaling by Leptin 11 9.12e-02 0.294000 2.62e-01
HS-GAG degradation 20 9.18e-02 -0.218000 2.63e-01
Lagging Strand Synthesis 19 9.20e-02 -0.223000 2.63e-01
Adaptive Immune System 691 9.26e-02 0.037700 2.64e-01
Activation of NMDA receptors and postsynaptic events 71 9.26e-02 0.115000 2.64e-01
TBC/RABGAPs 44 9.47e-02 0.146000 2.69e-01
Presynaptic function of Kainate receptors 21 9.49e-02 -0.211000 2.69e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 9.49e-02 -0.268000 2.69e-01
RET signaling 39 9.68e-02 -0.154000 2.74e-01
Developmental Biology 866 9.74e-02 -0.033300 2.75e-01
Phase 4 - resting membrane potential 18 9.75e-02 -0.226000 2.75e-01
Diseases of glycosylation 132 9.97e-02 -0.083000 2.80e-01
tRNA modification in the nucleus and cytosol 42 1.01e-01 0.146000 2.83e-01
FGFR1 mutant receptor activation 28 1.02e-01 0.179000 2.84e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 1.02e-01 -0.299000 2.84e-01
Cap-dependent Translation Initiation 93 1.02e-01 0.098100 2.85e-01
Eukaryotic Translation Initiation 93 1.02e-01 0.098100 2.85e-01
NCAM signaling for neurite out-growth 52 1.04e-01 -0.130000 2.88e-01
HDMs demethylate histones 21 1.04e-01 -0.205000 2.89e-01
Protein methylation 14 1.05e-01 0.250000 2.92e-01
Activation of Matrix Metalloproteinases 28 1.06e-01 -0.176000 2.94e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.09e-01 -0.224000 3.01e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 60 1.10e-01 0.119000 3.02e-01
RNA Polymerase III Transcription Termination 19 1.10e-01 0.212000 3.02e-01
Uptake and actions of bacterial toxins 26 1.11e-01 0.181000 3.05e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 99 1.12e-01 -0.092500 3.07e-01
Pre-NOTCH Transcription and Translation 47 1.12e-01 -0.134000 3.07e-01
Amino acid transport across the plasma membrane 32 1.14e-01 -0.161000 3.12e-01
Inwardly rectifying K+ channels 35 1.14e-01 -0.154000 3.12e-01
Signaling by Erythropoietin 25 1.16e-01 -0.182000 3.15e-01
RAB GEFs exchange GTP for GDP on RABs 85 1.16e-01 0.098600 3.15e-01
Synthesis of IP3 and IP4 in the cytosol 26 1.17e-01 0.178000 3.17e-01
VEGFA-VEGFR2 Pathway 91 1.18e-01 -0.094800 3.18e-01
Nuclear Envelope Breakdown 50 1.18e-01 -0.128000 3.18e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 1.18e-01 0.202000 3.18e-01
GABA synthesis, release, reuptake and degradation 18 1.19e-01 0.212000 3.18e-01
HIV elongation arrest and recovery 34 1.19e-01 0.155000 3.18e-01
Pausing and recovery of HIV elongation 34 1.19e-01 0.155000 3.18e-01
GABA receptor activation 57 1.20e-01 -0.119000 3.19e-01
Ion homeostasis 47 1.20e-01 0.131000 3.19e-01
RNA Polymerase III Transcription Initiation 32 1.20e-01 0.159000 3.19e-01
Glucagon-type ligand receptors 31 1.20e-01 -0.161000 3.20e-01
TRAF3-dependent IRF activation pathway 12 1.22e-01 0.258000 3.24e-01
Dermatan sulfate biosynthesis 11 1.22e-01 -0.269000 3.24e-01
FOXO-mediated transcription of cell cycle genes 16 1.23e-01 -0.223000 3.26e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 1.24e-01 0.238000 3.26e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 1.24e-01 0.238000 3.26e-01
Signaling by NTRK2 (TRKB) 25 1.26e-01 -0.177000 3.30e-01
Olfactory Signaling Pathway 123 1.26e-01 -0.080000 3.30e-01
Heme biosynthesis 13 1.26e-01 0.245000 3.30e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 17 1.26e-01 -0.214000 3.30e-01
Phosphorylation of the APC/C 19 1.27e-01 -0.202000 3.31e-01
Chondroitin sulfate/dermatan sulfate metabolism 49 1.27e-01 -0.126000 3.31e-01
Activation of GABAB receptors 43 1.29e-01 -0.134000 3.34e-01
GABA B receptor activation 43 1.29e-01 -0.134000 3.34e-01
DNA methylation 15 1.29e-01 -0.227000 3.34e-01
Synthesis of PIPs at the late endosome membrane 11 1.30e-01 0.264000 3.36e-01
Activation of the AP-1 family of transcription factors 10 1.30e-01 0.276000 3.36e-01
Signaling by TGF-beta Receptor Complex 69 1.30e-01 0.105000 3.36e-01
Adrenaline,noradrenaline inhibits insulin secretion 28 1.31e-01 -0.165000 3.36e-01
Nucleobase biosynthesis 13 1.32e-01 0.241000 3.39e-01
ADP signalling through P2Y purinoceptor 12 22 1.32e-01 -0.185000 3.39e-01
Peptide ligand-binding receptors 158 1.33e-01 -0.069300 3.40e-01
ZBP1(DAI) mediated induction of type I IFNs 19 1.33e-01 0.199000 3.40e-01
Muscle contraction 177 1.34e-01 0.065400 3.40e-01
MAPK family signaling cascades 307 1.34e-01 0.049900 3.40e-01
Other semaphorin interactions 19 1.34e-01 -0.199000 3.40e-01
Nitric oxide stimulates guanylate cyclase 19 1.34e-01 -0.199000 3.40e-01
O-linked glycosylation of mucins 53 1.35e-01 -0.119000 3.43e-01
Amine ligand-binding receptors 34 1.36e-01 -0.148000 3.43e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 15 1.36e-01 -0.222000 3.43e-01
Activation of G protein gated Potassium channels 29 1.37e-01 -0.160000 3.44e-01
G protein gated Potassium channels 29 1.37e-01 -0.160000 3.44e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 29 1.37e-01 -0.160000 3.44e-01
mRNA Capping 27 1.38e-01 0.165000 3.45e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 36 1.38e-01 -0.143000 3.45e-01
Diseases of carbohydrate metabolism 32 1.39e-01 0.151000 3.46e-01
Formation of the Early Elongation Complex 31 1.39e-01 0.153000 3.47e-01
Formation of the HIV-1 Early Elongation Complex 31 1.39e-01 0.153000 3.47e-01
Intracellular signaling by second messengers 302 1.41e-01 0.049300 3.52e-01
Negative regulation of MAPK pathway 42 1.42e-01 0.131000 3.52e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 37 1.42e-01 0.139000 3.53e-01
Chylomicron assembly 10 1.44e-01 -0.267000 3.56e-01
SARS-CoV Infections 138 1.45e-01 0.072000 3.56e-01
APC-Cdc20 mediated degradation of Nek2A 24 1.45e-01 -0.172000 3.56e-01
Collagen degradation 36 1.45e-01 -0.140000 3.56e-01
Apoptosis induced DNA fragmentation 12 1.46e-01 -0.242000 3.56e-01
Signaling by Non-Receptor Tyrosine Kinases 53 1.46e-01 -0.115000 3.56e-01
Signaling by PTK6 53 1.46e-01 -0.115000 3.56e-01
Cellular hexose transport 19 1.46e-01 0.193000 3.56e-01
Apoptotic cleavage of cell adhesion proteins 11 1.46e-01 -0.253000 3.56e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 1.47e-01 0.253000 3.56e-01
SUMOylation of DNA replication proteins 44 1.47e-01 -0.127000 3.56e-01
Pausing and recovery of Tat-mediated HIV elongation 32 1.47e-01 0.148000 3.56e-01
Tat-mediated HIV elongation arrest and recovery 32 1.47e-01 0.148000 3.56e-01
HIV Life Cycle 142 1.48e-01 0.070400 3.57e-01
Tandem pore domain potassium channels 11 1.48e-01 -0.252000 3.57e-01
Acyl chain remodelling of PC 26 1.48e-01 0.164000 3.57e-01
RNA Polymerase II Transcription 1083 1.49e-01 -0.026200 3.57e-01
Signaling by FGFR2 IIIa TM 17 1.49e-01 0.202000 3.57e-01
p75 NTR receptor-mediated signalling 92 1.49e-01 -0.087100 3.57e-01
STING mediated induction of host immune responses 16 1.49e-01 0.208000 3.58e-01
Response of Mtb to phagocytosis 21 1.50e-01 0.182000 3.58e-01
Uptake and function of anthrax toxins 10 1.50e-01 0.263000 3.58e-01
Negative regulation of the PI3K/AKT network 106 1.50e-01 -0.080900 3.58e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 21 1.51e-01 0.181000 3.60e-01
RA biosynthesis pathway 18 1.53e-01 0.195000 3.62e-01
RNA Polymerase I Promoter Clearance 56 1.53e-01 0.110000 3.62e-01
RNA Polymerase I Transcription 56 1.53e-01 0.110000 3.62e-01
Signaling by NOTCH2 29 1.53e-01 0.153000 3.62e-01
Regulation of KIT signaling 16 1.54e-01 -0.206000 3.62e-01
Interferon alpha/beta signaling 63 1.54e-01 -0.104000 3.62e-01
Presynaptic nicotinic acetylcholine receptors 10 1.54e-01 -0.260000 3.62e-01
SHC1 events in EGFR signaling 14 1.55e-01 -0.219000 3.65e-01
Norepinephrine Neurotransmitter Release Cycle 18 1.58e-01 0.192000 3.70e-01
GRB2 events in EGFR signaling 13 1.58e-01 -0.226000 3.70e-01
Molecules associated with elastic fibres 28 1.59e-01 -0.154000 3.70e-01
Signaling by FGFR4 in disease 11 1.59e-01 -0.245000 3.71e-01
Transcriptional Regulation by MECP2 56 1.60e-01 0.109000 3.72e-01
Glutathione conjugation 30 1.62e-01 -0.148000 3.76e-01
Serotonin Neurotransmitter Release Cycle 18 1.62e-01 0.190000 3.76e-01
Cilium Assembly 180 1.63e-01 -0.060400 3.76e-01
G beta:gamma signalling through PLC beta 20 1.63e-01 -0.180000 3.76e-01
MicroRNA (miRNA) biogenesis 24 1.63e-01 0.165000 3.76e-01
Late Phase of HIV Life Cycle 130 1.63e-01 0.070900 3.76e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 16 1.63e-01 -0.201000 3.76e-01
Diseases of hemostasis 16 1.63e-01 -0.201000 3.76e-01
G1/S-Specific Transcription 29 1.64e-01 -0.149000 3.76e-01
DCC mediated attractive signaling 14 1.65e-01 -0.215000 3.76e-01
Acetylcholine binding and downstream events 11 1.65e-01 -0.242000 3.76e-01
Postsynaptic nicotinic acetylcholine receptors 11 1.65e-01 -0.242000 3.76e-01
Formation of HIV elongation complex in the absence of HIV Tat 46 1.65e-01 0.118000 3.77e-01
FGFR2 mutant receptor activation 28 1.66e-01 0.151000 3.78e-01
Processing of Capped Intron-Containing Pre-mRNA 227 1.66e-01 -0.053400 3.78e-01
Aspartate and asparagine metabolism 10 1.66e-01 0.253000 3.78e-01
Creatine metabolism 10 1.67e-01 0.253000 3.78e-01
rRNA modification in the nucleus and cytosol 57 1.67e-01 0.106000 3.79e-01
Regulation of localization of FOXO transcription factors 11 1.70e-01 0.239000 3.84e-01
Interaction With Cumulus Cells And The Zona Pellucida 10 1.70e-01 -0.251000 3.84e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 1.70e-01 0.229000 3.84e-01
TRAF6 mediated IRF7 activation 26 1.71e-01 -0.155000 3.84e-01
Telomere Extension By Telomerase 23 1.71e-01 -0.165000 3.84e-01
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) 10 1.72e-01 -0.249000 3.86e-01
TNFR1-induced NFkappaB signaling pathway 26 1.73e-01 0.155000 3.86e-01
SUMOylation of DNA methylation proteins 16 1.73e-01 0.197000 3.87e-01
Unblocking of NMDA receptors, glutamate binding and activation 20 1.76e-01 0.175000 3.90e-01
Folding of actin by CCT/TriC 10 1.76e-01 0.247000 3.90e-01
Translation of structural proteins 27 1.76e-01 0.151000 3.90e-01
Synthesis of IP2, IP, and Ins in the cytosol 14 1.76e-01 0.209000 3.90e-01
SUMOylation 163 1.76e-01 -0.061500 3.90e-01
IRF3-mediated induction of type I IFN 13 1.77e-01 0.216000 3.92e-01
RIP-mediated NFkB activation via ZBP1 15 1.78e-01 0.201000 3.92e-01
Membrane binding and targetting of GAG proteins 13 1.78e-01 0.216000 3.92e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 1.78e-01 0.216000 3.92e-01
Integrin cell surface interactions 60 1.78e-01 -0.101000 3.92e-01
GPVI-mediated activation cascade 32 1.78e-01 -0.138000 3.92e-01
RHO GTPases activate PKNs 44 1.79e-01 -0.117000 3.93e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 19 1.81e-01 -0.177000 3.96e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 1.81e-01 0.158000 3.96e-01
Interleukin-37 signaling 19 1.81e-01 0.177000 3.96e-01
Sphingolipid de novo biosynthesis 43 1.82e-01 -0.118000 3.97e-01
cGMP effects 15 1.84e-01 -0.198000 4.01e-01
RNA Polymerase I Promoter Escape 38 1.84e-01 0.125000 4.01e-01
p130Cas linkage to MAPK signaling for integrins 15 1.85e-01 -0.198000 4.01e-01
The canonical retinoid cycle in rods (twilight vision) 23 1.85e-01 -0.160000 4.02e-01
Interleukin-15 signaling 14 1.85e-01 0.204000 4.02e-01
PD-1 signaling 18 1.87e-01 0.180000 4.02e-01
IRAK4 deficiency (TLR2/4) 10 1.87e-01 -0.241000 4.02e-01
MAPK targets/ Nuclear events mediated by MAP kinases 30 1.87e-01 0.139000 4.02e-01
Nuclear Pore Complex (NPC) Disassembly 34 1.88e-01 -0.131000 4.02e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 29 1.88e-01 0.141000 4.02e-01
Trafficking of AMPA receptors 29 1.88e-01 0.141000 4.02e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 1.89e-01 -0.211000 4.04e-01
Defective EXT2 causes exostoses 2 13 1.89e-01 -0.211000 4.04e-01
Activation of HOX genes during differentiation 65 1.89e-01 -0.094100 4.04e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 65 1.89e-01 -0.094100 4.04e-01
Plasma lipoprotein assembly 18 1.90e-01 -0.178000 4.05e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 1.91e-01 0.228000 4.05e-01
Long-term potentiation 22 1.91e-01 0.161000 4.05e-01
Growth hormone receptor signaling 21 1.91e-01 0.165000 4.05e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 1.91e-01 0.087900 4.05e-01
Organic anion transporters 10 1.92e-01 0.239000 4.05e-01
Platelet activation, signaling and aggregation 252 1.92e-01 -0.047800 4.05e-01
Removal of the Flap Intermediate from the C-strand 16 1.93e-01 -0.188000 4.07e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 12 1.93e-01 -0.217000 4.07e-01
MET activates RAP1 and RAC1 11 1.94e-01 -0.226000 4.07e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 1.94e-01 0.156000 4.07e-01
Regulation of TNFR1 signaling 34 1.94e-01 0.129000 4.07e-01
Pre-NOTCH Expression and Processing 63 1.98e-01 -0.093900 4.14e-01
Cohesin Loading onto Chromatin 10 1.98e-01 -0.235000 4.14e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 44 1.99e-01 0.112000 4.14e-01
HIV Transcription Elongation 44 1.99e-01 0.112000 4.14e-01
Tat-mediated elongation of the HIV-1 transcript 44 1.99e-01 0.112000 4.14e-01
Signaling by FGFR3 fusions in cancer 10 2.00e-01 -0.234000 4.15e-01
Na+/Cl- dependent neurotransmitter transporters 17 2.00e-01 -0.179000 4.15e-01
G beta:gamma signalling through PI3Kgamma 25 2.01e-01 -0.148000 4.16e-01
L1CAM interactions 98 2.02e-01 0.074700 4.17e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 35 2.04e-01 -0.124000 4.21e-01
Diseases of mitotic cell cycle 35 2.04e-01 -0.124000 4.21e-01
Zinc influx into cells by the SLC39 gene family 10 2.04e-01 -0.232000 4.21e-01
Endosomal/Vacuolar pathway 10 2.06e-01 -0.231000 4.23e-01
Potential therapeutics for SARS 76 2.08e-01 0.083600 4.26e-01
Transcriptional Regulation by TP53 342 2.08e-01 0.039700 4.26e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 2.09e-01 0.155000 4.26e-01
NR1H2 and NR1H3-mediated signaling 48 2.09e-01 -0.105000 4.26e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 24 2.09e-01 -0.148000 4.26e-01
Purine salvage 13 2.10e-01 0.201000 4.26e-01
HIV Transcription Initiation 42 2.10e-01 0.112000 4.26e-01
RNA Polymerase II HIV Promoter Escape 42 2.10e-01 0.112000 4.26e-01
RNA Polymerase II Promoter Escape 42 2.10e-01 0.112000 4.26e-01
RNA Polymerase II Transcription Initiation 42 2.10e-01 0.112000 4.26e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 42 2.10e-01 0.112000 4.26e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 42 2.10e-01 0.112000 4.26e-01
Digestion and absorption 21 2.12e-01 -0.157000 4.28e-01
O-glycosylation of TSR domain-containing proteins 37 2.12e-01 -0.118000 4.28e-01
Thrombin signalling through proteinase activated receptors (PARs) 31 2.13e-01 -0.129000 4.30e-01
EPHA-mediated growth cone collapse 15 2.15e-01 -0.185000 4.33e-01
Chemokine receptors bind chemokines 42 2.17e-01 -0.110000 4.35e-01
SUMO E3 ligases SUMOylate target proteins 157 2.17e-01 -0.057200 4.35e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 2.19e-01 0.130000 4.38e-01
EPH-Ephrin signaling 90 2.21e-01 -0.074600 4.43e-01
CD209 (DC-SIGN) signaling 19 2.24e-01 -0.161000 4.46e-01
Transcriptional Regulation by E2F6 32 2.25e-01 -0.124000 4.49e-01
Passive transport by Aquaporins 11 2.27e-01 0.210000 4.52e-01
ABC transporters in lipid homeostasis 17 2.29e-01 0.169000 4.54e-01
Organelle biogenesis and maintenance 267 2.29e-01 0.042900 4.54e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 87 2.30e-01 0.074500 4.55e-01
Deadenylation-dependent mRNA decay 51 2.30e-01 -0.097200 4.55e-01
RAF-independent MAPK1/3 activation 23 2.31e-01 0.144000 4.56e-01
Phenylalanine and tyrosine metabolism 11 2.32e-01 -0.208000 4.58e-01
Arachidonic acid metabolism 54 2.33e-01 -0.093900 4.59e-01
Signaling by PDGF 50 2.33e-01 -0.097600 4.59e-01
Dual Incision in GG-NER 39 2.34e-01 0.110000 4.60e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 29 2.34e-01 -0.128000 4.60e-01
Regulation of PTEN gene transcription 58 2.34e-01 0.090300 4.60e-01
L13a-mediated translational silencing of Ceruloplasmin expression 85 2.37e-01 0.074200 4.65e-01
Semaphorin interactions 63 2.39e-01 -0.085700 4.69e-01
Interferon Signaling 178 2.40e-01 0.051100 4.69e-01
Nicotinamide salvaging 19 2.41e-01 0.155000 4.70e-01
InlB-mediated entry of Listeria monocytogenes into host cell 14 2.41e-01 0.181000 4.70e-01
p75NTR recruits signalling complexes 12 2.45e-01 0.194000 4.77e-01
HDR through MMEJ (alt-NHEJ) 10 2.46e-01 -0.212000 4.79e-01
TP53 Regulates Transcription of Cell Cycle Genes 47 2.47e-01 -0.097700 4.79e-01
Glutamate Neurotransmitter Release Cycle 24 2.50e-01 0.136000 4.83e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 31 2.50e-01 -0.119000 4.83e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 31 2.50e-01 -0.119000 4.83e-01
Infection with Mycobacterium tuberculosis 25 2.53e-01 0.132000 4.87e-01
Cytokine Signaling in Immune system 787 2.53e-01 0.024100 4.87e-01
Nucleotide-like (purinergic) receptors 15 2.53e-01 0.170000 4.88e-01
ADP signalling through P2Y purinoceptor 1 24 2.54e-01 -0.134000 4.89e-01
Regulation of TLR by endogenous ligand 15 2.59e-01 -0.168000 4.97e-01
Acyl chain remodelling of PI 16 2.59e-01 0.163000 4.97e-01
Metabolism of Angiotensinogen to Angiotensins 17 2.61e-01 -0.158000 4.99e-01
Urea cycle 10 2.61e-01 -0.205000 4.99e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 46 2.61e-01 -0.095800 4.99e-01
Nucleobase catabolism 35 2.62e-01 0.110000 4.99e-01
Amyloid fiber formation 56 2.62e-01 -0.086700 4.99e-01
TP53 Regulates Transcription of Cell Death Genes 34 2.63e-01 -0.111000 5.01e-01
GAB1 signalosome 17 2.64e-01 -0.157000 5.01e-01
Diseases associated with glycosaminoglycan metabolism 39 2.64e-01 -0.103000 5.02e-01
Methylation 14 2.66e-01 0.172000 5.03e-01
Basigin interactions 24 2.68e-01 -0.131000 5.07e-01
Suppression of phagosomal maturation 12 2.69e-01 0.184000 5.07e-01
Transport of the SLBP Dependant Mature mRNA 35 2.69e-01 -0.108000 5.07e-01
ISG15 antiviral mechanism 69 2.69e-01 0.077000 5.07e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 50 2.72e-01 0.089900 5.10e-01
Defective B3GAT3 causes JDSSDHD 19 2.72e-01 -0.146000 5.10e-01
Tryptophan catabolism 14 2.72e-01 -0.170000 5.10e-01
Bicarbonate transporters 10 2.72e-01 0.201000 5.10e-01
APC/C:Cdc20 mediated degradation of Cyclin B 22 2.73e-01 -0.135000 5.12e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 2.74e-01 -0.158000 5.12e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 11 2.74e-01 0.190000 5.12e-01
Phase II - Conjugation of compounds 79 2.75e-01 -0.071100 5.13e-01
Cell-cell junction organization 60 2.76e-01 -0.081400 5.13e-01
RHO GTPases activate KTN1 10 2.77e-01 0.198000 5.13e-01
G alpha (z) signalling events 48 2.77e-01 -0.090700 5.13e-01
Signaling by VEGF 100 2.78e-01 -0.062900 5.13e-01
PI3K/AKT Signaling in Cancer 97 2.78e-01 -0.063800 5.13e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 2.79e-01 -0.152000 5.13e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 2.79e-01 -0.152000 5.13e-01
WNT5A-dependent internalization of FZD4 15 2.79e-01 0.161000 5.13e-01
RHO GTPases activate PAKs 21 2.79e-01 -0.136000 5.13e-01
Neurexins and neuroligins 54 2.79e-01 -0.085100 5.13e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 54 2.81e-01 0.084900 5.13e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 54 2.81e-01 0.084900 5.13e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 54 2.81e-01 0.084900 5.13e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 54 2.81e-01 0.084900 5.13e-01
Signaling by NOTCH1 in Cancer 54 2.81e-01 0.084900 5.13e-01
Influenza Infection 128 2.81e-01 0.055200 5.13e-01
Processive synthesis on the lagging strand 14 2.81e-01 -0.166000 5.13e-01
Thromboxane signalling through TP receptor 23 2.81e-01 -0.130000 5.13e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 2.83e-01 0.187000 5.16e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 16 2.84e-01 -0.155000 5.16e-01
COPII-mediated vesicle transport 61 2.85e-01 0.079200 5.17e-01
Vpr-mediated nuclear import of PICs 32 2.85e-01 -0.109000 5.17e-01
SLC-mediated transmembrane transport 235 2.86e-01 -0.040500 5.18e-01
Downstream signaling of activated FGFR1 28 2.87e-01 -0.116000 5.19e-01
Regulation of TP53 Activity through Methylation 16 2.87e-01 0.154000 5.19e-01
Keratan sulfate biosynthesis 26 2.88e-01 -0.120000 5.19e-01
SUMOylation of SUMOylation proteins 34 2.88e-01 -0.105000 5.19e-01
Integration of energy metabolism 103 2.89e-01 -0.060500 5.19e-01
Miscellaneous transport and binding events 23 2.89e-01 -0.128000 5.19e-01
Lysosphingolipid and LPA receptors 14 2.90e-01 -0.163000 5.19e-01
SUMOylation of ubiquitinylation proteins 38 2.90e-01 -0.099300 5.19e-01
SUMOylation of intracellular receptors 30 2.90e-01 -0.112000 5.19e-01
Gene expression (Transcription) 1215 2.90e-01 -0.018100 5.20e-01
Transport of the SLBP independent Mature mRNA 34 2.92e-01 -0.105000 5.21e-01
Caspase activation via Death Receptors in the presence of ligand 11 2.93e-01 -0.183000 5.23e-01
Negative epigenetic regulation of rRNA expression 57 2.93e-01 0.080500 5.23e-01
Transcription of the HIV genome 68 2.93e-01 0.073700 5.23e-01
Anchoring of the basal body to the plasma membrane 94 2.94e-01 -0.062700 5.23e-01
NEP/NS2 Interacts with the Cellular Export Machinery 31 2.95e-01 -0.109000 5.24e-01
Neurotransmitter clearance 10 2.98e-01 -0.190000 5.29e-01
Acyl chain remodelling of PE 26 3.01e-01 0.117000 5.34e-01
AURKA Activation by TPX2 70 3.02e-01 -0.071400 5.34e-01
MAPK3 (ERK1) activation 10 3.03e-01 0.188000 5.36e-01
Metabolism of porphyrins 24 3.04e-01 0.121000 5.36e-01
NOD1/2 Signaling Pathway 30 3.05e-01 0.108000 5.37e-01
RNA Polymerase III Abortive And Retractive Initiation 37 3.05e-01 0.097400 5.37e-01
RNA Polymerase III Transcription 37 3.05e-01 0.097400 5.37e-01
Translation initiation complex formation 49 3.07e-01 0.084400 5.40e-01
SUMOylation of chromatin organization proteins 56 3.08e-01 -0.078700 5.41e-01
Metabolism of steroid hormones 27 3.13e-01 -0.112000 5.49e-01
MET receptor recycling 10 3.15e-01 0.184000 5.51e-01
Endogenous sterols 24 3.16e-01 -0.118000 5.52e-01
Signaling by high-kinase activity BRAF mutants 34 3.16e-01 -0.099400 5.52e-01
Regulation of signaling by CBL 18 3.17e-01 -0.136000 5.52e-01
Bile acid and bile salt metabolism 38 3.17e-01 -0.093800 5.52e-01
Heparan sulfate/heparin (HS-GAG) metabolism 51 3.18e-01 -0.080900 5.52e-01
Effects of PIP2 hydrolysis 26 3.18e-01 -0.113000 5.52e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 10 3.18e-01 0.182000 5.53e-01
LDL clearance 18 3.20e-01 0.136000 5.54e-01
HDACs deacetylate histones 39 3.20e-01 -0.092100 5.54e-01
Processing and activation of SUMO 10 3.21e-01 -0.181000 5.56e-01
Assembly and cell surface presentation of NMDA receptors 23 3.24e-01 0.119000 5.59e-01
NRIF signals cell death from the nucleus 15 3.24e-01 0.147000 5.59e-01
Defective B4GALT7 causes EDS, progeroid type 19 3.25e-01 -0.130000 5.61e-01
Signaling by EGFR in Cancer 23 3.28e-01 -0.118000 5.62e-01
Signaling by FGFR1 44 3.28e-01 -0.085200 5.62e-01
Signaling by FGFR in disease 57 3.28e-01 0.074900 5.62e-01
Formation of RNA Pol II elongation complex 59 3.28e-01 0.073600 5.62e-01
RNA Polymerase II Transcription Elongation 59 3.28e-01 0.073600 5.62e-01
Metalloprotease DUBs 18 3.28e-01 0.133000 5.62e-01
Notch-HLH transcription pathway 26 3.30e-01 -0.110000 5.64e-01
Signal regulatory protein family interactions 12 3.30e-01 0.162000 5.64e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 3.32e-01 -0.136000 5.65e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 19 3.32e-01 -0.129000 5.65e-01
Metabolism of water-soluble vitamins and cofactors 119 3.33e-01 0.051500 5.66e-01
mRNA Splicing 176 3.34e-01 -0.042300 5.67e-01
Heme degradation 13 3.34e-01 -0.155000 5.67e-01
Resolution of Abasic Sites (AP sites) 37 3.35e-01 -0.091600 5.68e-01
Regulation of TP53 Activity through Acetylation 28 3.36e-01 0.105000 5.69e-01
Signaling by FGFR 74 3.37e-01 -0.064600 5.70e-01
Regulation of TP53 Expression and Degradation 34 3.39e-01 0.094900 5.72e-01
Cargo concentration in the ER 29 3.39e-01 0.103000 5.72e-01
FGFRL1 modulation of FGFR1 signaling 11 3.42e-01 -0.165000 5.76e-01
Signaling by BMP 26 3.42e-01 0.108000 5.76e-01
Polo-like kinase mediated events 15 3.45e-01 -0.141000 5.79e-01
Synthesis of DNA 115 3.45e-01 0.051000 5.79e-01
Elevation of cytosolic Ca2+ levels 16 3.46e-01 -0.136000 5.80e-01
Regulation of TP53 Degradation 33 3.46e-01 0.094800 5.80e-01
Interleukin-7 signaling 23 3.46e-01 0.113000 5.80e-01
Mitotic Prophase 89 3.47e-01 -0.057700 5.80e-01
Listeria monocytogenes entry into host cells 19 3.47e-01 0.125000 5.80e-01
Lysine catabolism 12 3.49e-01 0.156000 5.82e-01
Erythropoietin activates RAS 14 3.49e-01 -0.144000 5.82e-01
Signaling by NTRKs 129 3.49e-01 0.047700 5.82e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 3.52e-01 -0.115000 5.84e-01
Vitamin B5 (pantothenate) metabolism 15 3.54e-01 -0.138000 5.88e-01
Insulin receptor recycling 25 3.56e-01 0.107000 5.90e-01
Signaling by ERBB2 in Cancer 24 3.57e-01 -0.109000 5.91e-01
Removal of the Flap Intermediate 13 3.58e-01 -0.147000 5.91e-01
Signaling by NTRK1 (TRKA) 110 3.58e-01 0.050800 5.91e-01
Pregnenolone biosynthesis 11 3.63e-01 -0.158000 5.99e-01
Biosynthesis of DHA-derived SPMs 16 3.63e-01 -0.131000 5.99e-01
TP53 Regulates Transcription of DNA Repair Genes 61 3.65e-01 0.067100 5.99e-01
HATs acetylate histones 84 3.65e-01 0.057200 5.99e-01
RHO GTPases Activate NADPH Oxidases 23 3.65e-01 0.109000 5.99e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 11 3.65e-01 -0.158000 5.99e-01
G2/M Transition 175 3.66e-01 0.039700 5.99e-01
Neuronal System 368 3.67e-01 -0.027500 6.00e-01
Intraflagellar transport 39 3.67e-01 -0.083400 6.00e-01
Prostacyclin signalling through prostacyclin receptor 19 3.67e-01 -0.119000 6.00e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 3.68e-01 -0.150000 6.00e-01
Signal amplification 32 3.68e-01 -0.091900 6.00e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 12 3.70e-01 0.149000 6.02e-01
Formation of ATP by chemiosmotic coupling 15 3.71e-01 0.133000 6.02e-01
Nuclear import of Rev protein 33 3.71e-01 -0.090000 6.02e-01
Formation of the beta-catenin:TCF transactivating complex 41 3.71e-01 -0.080700 6.02e-01
mRNA Splicing - Major Pathway 168 3.71e-01 -0.040000 6.02e-01
Interleukin-12 family signaling 50 3.72e-01 0.073000 6.02e-01
SIRT1 negatively regulates rRNA expression 18 3.73e-01 -0.121000 6.03e-01
NF-kB is activated and signals survival 11 3.73e-01 0.155000 6.03e-01
Cyclin D associated events in G1 43 3.74e-01 -0.078300 6.03e-01
G1 Phase 43 3.74e-01 -0.078300 6.03e-01
Ribosomal scanning and start codon recognition 50 3.75e-01 0.072500 6.03e-01
Inhibition of DNA recombination at telomere 29 3.75e-01 -0.095200 6.03e-01
Glycerophospholipid biosynthesis 124 3.75e-01 0.046100 6.03e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 3.76e-01 0.096700 6.03e-01
Detoxification of Reactive Oxygen Species 33 3.77e-01 0.089000 6.04e-01
Generic Transcription Pathway 967 3.78e-01 -0.016900 6.05e-01
Transport of vitamins, nucleosides, and related molecules 41 3.79e-01 -0.079400 6.06e-01
Formation of a pool of free 40S subunits 77 3.80e-01 0.057900 6.07e-01
Ephrin signaling 19 3.81e-01 -0.116000 6.07e-01
FGFR2 ligand binding and activation 15 3.81e-01 0.131000 6.08e-01
Plasma lipoprotein clearance 32 3.84e-01 0.088900 6.12e-01
Immune System 1904 3.85e-01 0.012200 6.13e-01
Organic cation/anion/zwitterion transport 12 3.87e-01 -0.144000 6.14e-01
Metal ion SLC transporters 26 3.89e-01 -0.097600 6.17e-01
Regulation of signaling by NODAL 10 3.89e-01 -0.157000 6.17e-01
p75NTR signals via NF-kB 14 3.90e-01 0.133000 6.17e-01
Signaling by SCF-KIT 42 3.90e-01 -0.076700 6.17e-01
NoRC negatively regulates rRNA expression 54 3.91e-01 0.067600 6.17e-01
Transport of Ribonucleoproteins into the Host Nucleus 31 3.93e-01 -0.088700 6.20e-01
Ion transport by P-type ATPases 51 3.93e-01 -0.069100 6.20e-01
Intrinsic Pathway for Apoptosis 47 3.96e-01 0.071600 6.23e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 15 3.96e-01 -0.127000 6.23e-01
RNA Polymerase II Pre-transcription Events 79 3.97e-01 0.055100 6.24e-01
Antiviral mechanism by IFN-stimulated genes 77 3.98e-01 0.055700 6.25e-01
DNA Repair 281 3.99e-01 -0.029300 6.25e-01
Stimuli-sensing channels 96 4.00e-01 -0.049800 6.25e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 41 4.00e-01 -0.076000 6.25e-01
CD28 co-stimulation 33 4.00e-01 -0.084700 6.25e-01
Transcriptional Regulation by VENTX 36 4.01e-01 -0.080900 6.26e-01
Downstream signal transduction 29 4.04e-01 0.089500 6.30e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 49 4.05e-01 0.068800 6.31e-01
Apoptotic factor-mediated response 15 4.06e-01 0.124000 6.31e-01
Neutrophil degranulation 441 4.06e-01 0.023100 6.31e-01
Retrograde transport at the Trans-Golgi-Network 46 4.07e-01 0.070700 6.31e-01
Beta defensins 12 4.07e-01 -0.138000 6.31e-01
SUMOylation of DNA damage response and repair proteins 73 4.07e-01 -0.056100 6.31e-01
Mitotic G2-G2/M phases 177 4.09e-01 0.036000 6.34e-01
Formation of apoptosome 10 4.12e-01 0.150000 6.37e-01
Regulation of the apoptosome activity 10 4.12e-01 0.150000 6.37e-01
Gastrin-CREB signalling pathway via PKC and MAPK 17 4.15e-01 -0.114000 6.40e-01
Diseases associated with N-glycosylation of proteins 16 4.16e-01 -0.117000 6.40e-01
RHO GTPases Activate ROCKs 19 4.17e-01 -0.108000 6.40e-01
IL-6-type cytokine receptor ligand interactions 17 4.17e-01 0.114000 6.40e-01
MECP2 regulates neuronal receptors and channels 16 4.17e-01 -0.117000 6.40e-01
Cargo recognition for clathrin-mediated endocytosis 101 4.18e-01 0.046700 6.40e-01
Adenylate cyclase activating pathway 10 4.18e-01 -0.148000 6.40e-01
Diseases associated with visual transduction 13 4.19e-01 -0.130000 6.40e-01
Diseases of the neuronal system 13 4.19e-01 -0.130000 6.40e-01
Retinoid cycle disease events 13 4.19e-01 -0.130000 6.40e-01
Hyaluronan uptake and degradation 12 4.21e-01 0.134000 6.41e-01
Cell recruitment (pro-inflammatory response) 22 4.21e-01 -0.099100 6.41e-01
Purinergic signaling in leishmaniasis infection 22 4.21e-01 -0.099100 6.41e-01
Activation of SMO 18 4.21e-01 -0.110000 6.41e-01
Metabolism of vitamins and cofactors 179 4.22e-01 0.034800 6.41e-01
Repression of WNT target genes 14 4.23e-01 0.124000 6.41e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 19 4.23e-01 -0.106000 6.41e-01
TNFR1-induced proapoptotic signaling 13 4.25e-01 0.128000 6.41e-01
Fc epsilon receptor (FCERI) signaling 155 4.25e-01 0.037100 6.41e-01
Signaling by ERBB2 ECD mutants 14 4.26e-01 -0.123000 6.41e-01
DNA Double Strand Break Response 46 4.26e-01 -0.067900 6.41e-01
RORA activates gene expression 18 4.26e-01 -0.108000 6.41e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 10 4.26e-01 -0.145000 6.41e-01
Transcription of E2F targets under negative control by DREAM complex 19 4.26e-01 -0.105000 6.41e-01
Sema3A PAK dependent Axon repulsion 15 4.26e-01 -0.119000 6.41e-01
Regulation of PTEN mRNA translation 21 4.29e-01 -0.099600 6.43e-01
Hyaluronan metabolism 17 4.29e-01 -0.111000 6.43e-01
Pyrimidine salvage 10 4.30e-01 0.144000 6.43e-01
Sphingolipid metabolism 83 4.30e-01 0.050100 6.43e-01
Assembly Of The HIV Virion 15 4.30e-01 0.118000 6.43e-01
HCMV Early Events 67 4.30e-01 -0.055700 6.43e-01
Response of EIF2AK1 (HRI) to heme deficiency 15 4.31e-01 0.118000 6.44e-01
Mucopolysaccharidoses 11 4.32e-01 -0.137000 6.44e-01
Interleukin receptor SHC signaling 26 4.32e-01 0.089000 6.44e-01
ECM proteoglycans 53 4.32e-01 -0.062400 6.44e-01
Activation of kainate receptors upon glutamate binding 30 4.33e-01 -0.082800 6.44e-01
G-protein activation 28 4.33e-01 -0.085600 6.44e-01
Intra-Golgi traffic 42 4.39e-01 0.069000 6.52e-01
RNA Polymerase I Promoter Opening 13 4.40e-01 -0.124000 6.53e-01
Apoptotic execution phase 51 4.44e-01 -0.062000 6.57e-01
Export of Viral Ribonucleoproteins from Nucleus 32 4.44e-01 -0.078200 6.57e-01
Formation of tubulin folding intermediates by CCT/TriC 21 4.46e-01 0.096100 6.59e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 39 4.47e-01 -0.070300 6.61e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 23 4.50e-01 -0.091000 6.63e-01
Signaling by FGFR3 in disease 20 4.50e-01 -0.097500 6.63e-01
Signaling by FGFR3 point mutants in cancer 20 4.50e-01 -0.097500 6.63e-01
Transcriptional regulation by small RNAs 54 4.52e-01 -0.059200 6.65e-01
MAP2K and MAPK activation 38 4.55e-01 -0.070000 6.69e-01
Spry regulation of FGF signaling 14 4.55e-01 0.115000 6.69e-01
Nonhomologous End-Joining (NHEJ) 40 4.56e-01 -0.068100 6.69e-01
HCMV Infection 89 4.61e-01 0.045300 6.74e-01
Keratan sulfate/keratin metabolism 31 4.61e-01 -0.076500 6.74e-01
HCMV Late Events 61 4.61e-01 0.054600 6.74e-01
ESR-mediated signaling 165 4.64e-01 -0.033100 6.77e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 4.64e-01 -0.097000 6.77e-01
Other interleukin signaling 21 4.66e-01 -0.091900 6.79e-01
Activation of RAC1 13 4.68e-01 -0.116000 6.81e-01
Signaling by Activin 13 4.69e-01 -0.116000 6.81e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 68 4.69e-01 0.050800 6.81e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 15 4.70e-01 -0.108000 6.81e-01
Synthesis of PIPs at the Golgi membrane 18 4.70e-01 0.098400 6.81e-01
Phospholipase C-mediated cascade: FGFR1 13 4.70e-01 -0.116000 6.81e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 37 4.70e-01 0.068600 6.81e-01
Synthesis of PE 13 4.71e-01 0.115000 6.81e-01
PKA activation in glucagon signalling 16 4.72e-01 0.104000 6.82e-01
Adherens junctions interactions 31 4.73e-01 -0.074500 6.82e-01
B-WICH complex positively regulates rRNA expression 39 4.74e-01 0.066300 6.82e-01
VEGFR2 mediated vascular permeability 26 4.74e-01 0.081200 6.82e-01
Tight junction interactions 28 4.76e-01 -0.077900 6.84e-01
Digestion 16 4.76e-01 -0.103000 6.84e-01
G2/M Checkpoints 133 4.76e-01 -0.035800 6.84e-01
Interactions of Rev with host cellular proteins 36 4.77e-01 -0.068500 6.84e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 15 4.79e-01 0.106000 6.87e-01
Infectious disease 757 4.80e-01 0.015200 6.87e-01
Termination of O-glycan biosynthesis 17 4.81e-01 -0.098800 6.88e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 20 4.81e-01 -0.090900 6.88e-01
Ion channel transport 168 4.82e-01 -0.031400 6.89e-01
Signalling to ERKs 33 4.84e-01 0.070400 6.91e-01
SUMOylation of transcription factors 16 4.85e-01 0.101000 6.91e-01
Loss of Nlp from mitotic centrosomes 67 4.86e-01 -0.049200 6.91e-01
Loss of proteins required for interphase microtubule organization from the centrosome 67 4.86e-01 -0.049200 6.91e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 45 4.87e-01 -0.060000 6.91e-01
Fertilization 21 4.89e-01 -0.087200 6.93e-01
Interaction between L1 and Ankyrins 29 4.90e-01 0.074100 6.93e-01
AKT phosphorylates targets in the cytosol 14 4.90e-01 0.107000 6.93e-01
Formation of the ternary complex, and subsequently, the 43S complex 44 4.91e-01 0.060000 6.93e-01
TRP channels 25 4.92e-01 -0.079500 6.93e-01
Centrosome maturation 79 4.92e-01 -0.044800 6.93e-01
Recruitment of mitotic centrosome proteins and complexes 79 4.92e-01 -0.044800 6.93e-01
rRNA processing 187 4.92e-01 0.029200 6.93e-01
RNA polymerase II transcribes snRNA genes 68 4.92e-01 0.048200 6.93e-01
Metabolism of amine-derived hormones 17 4.93e-01 -0.096100 6.93e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 4.93e-01 -0.114000 6.93e-01
Protein-protein interactions at synapses 83 4.94e-01 -0.043500 6.93e-01
Signaling by FGFR1 in disease 35 4.94e-01 0.066800 6.93e-01
Nuclear signaling by ERBB4 29 4.96e-01 0.073100 6.94e-01
Formation of Incision Complex in GG-NER 42 4.97e-01 0.060600 6.95e-01
SARS-CoV-2 Infection 64 4.98e-01 0.049000 6.97e-01
Regulation of PLK1 Activity at G2/M Transition 83 4.99e-01 -0.042900 6.97e-01
HS-GAG biosynthesis 28 4.99e-01 -0.073800 6.97e-01
Biosynthesis of specialized proresolving mediators (SPMs) 18 5.01e-01 -0.091700 6.98e-01
Negative regulation of FGFR2 signaling 29 5.03e-01 0.071900 7.00e-01
DNA Replication 122 5.03e-01 0.035100 7.00e-01
Depolymerisation of the Nuclear Lamina 15 5.05e-01 -0.099500 7.02e-01
Insulin receptor signalling cascade 50 5.07e-01 -0.054200 7.02e-01
PKMTs methylate histone lysines 43 5.08e-01 -0.058300 7.02e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 5.08e-01 -0.078000 7.02e-01
A tetrasaccharide linker sequence is required for GAG synthesis 25 5.09e-01 -0.076300 7.02e-01
Recruitment of NuMA to mitotic centrosomes 78 5.10e-01 -0.043200 7.02e-01
Misspliced GSK3beta mutants stabilize beta-catenin 14 5.10e-01 0.102000 7.02e-01
S33 mutants of beta-catenin aren't phosphorylated 14 5.10e-01 0.102000 7.02e-01
S37 mutants of beta-catenin aren't phosphorylated 14 5.10e-01 0.102000 7.02e-01
S45 mutants of beta-catenin aren't phosphorylated 14 5.10e-01 0.102000 7.02e-01
T41 mutants of beta-catenin aren't phosphorylated 14 5.10e-01 0.102000 7.02e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 14 5.10e-01 0.102000 7.02e-01
ROS and RNS production in phagocytes 34 5.11e-01 0.065200 7.02e-01
Interactions of Vpr with host cellular proteins 34 5.12e-01 -0.065100 7.02e-01
SUMOylation of RNA binding proteins 45 5.12e-01 -0.056500 7.02e-01
Signaling by Hippo 20 5.14e-01 -0.084300 7.04e-01
Interleukin-2 family signaling 41 5.15e-01 0.058800 7.05e-01
Downstream signaling of activated FGFR3 23 5.16e-01 -0.078300 7.05e-01
Synthesis of PIPs at the early endosome membrane 16 5.16e-01 0.093900 7.05e-01
Voltage gated Potassium channels 41 5.18e-01 -0.058400 7.06e-01
Signal attenuation 10 5.18e-01 -0.118000 7.06e-01
Diseases of DNA repair 10 5.18e-01 -0.118000 7.06e-01
Signaling by FGFR2 in disease 38 5.21e-01 0.060100 7.10e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 42 5.24e-01 0.056900 7.12e-01
Zinc transporters 17 5.25e-01 -0.089100 7.13e-01
FRS-mediated FGFR1 signaling 20 5.25e-01 -0.082100 7.13e-01
Diseases associated with the TLR signaling cascade 20 5.27e-01 -0.081800 7.13e-01
Diseases of Immune System 20 5.27e-01 -0.081800 7.13e-01
Postmitotic nuclear pore complex (NPC) reformation 26 5.27e-01 -0.071700 7.13e-01
Cytochrome c-mediated apoptotic response 12 5.30e-01 0.105000 7.17e-01
Interleukin-4 and Interleukin-13 signaling 101 5.34e-01 -0.035800 7.22e-01
Signaling by ERBB2 KD Mutants 23 5.35e-01 -0.074700 7.23e-01
Glucagon signaling in metabolic regulation 31 5.37e-01 -0.064100 7.24e-01
Signaling by WNT 271 5.39e-01 0.021700 7.25e-01
Activation of Ca-permeable Kainate Receptor 10 5.39e-01 0.112000 7.25e-01
Ionotropic activity of kainate receptors 10 5.39e-01 0.112000 7.25e-01
Cardiac conduction 117 5.40e-01 0.032800 7.26e-01
MET promotes cell motility 29 5.45e-01 -0.064900 7.32e-01
VxPx cargo-targeting to cilium 21 5.46e-01 -0.076000 7.33e-01
Frs2-mediated activation 12 5.47e-01 0.100000 7.34e-01
Nuclear Events (kinase and transcription factor activation) 57 5.51e-01 0.045700 7.38e-01
Regulation of lipid metabolism by PPARalpha 116 5.53e-01 0.031900 7.39e-01
Activated point mutants of FGFR2 14 5.53e-01 0.091600 7.39e-01
Signaling by MET 66 5.53e-01 0.042200 7.39e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 5.55e-01 0.091000 7.40e-01
Innate Immune System 947 5.56e-01 0.011400 7.40e-01
Eukaryotic Translation Elongation 70 5.57e-01 0.040600 7.41e-01
Influenza Viral RNA Transcription and Replication 109 5.57e-01 0.032600 7.41e-01
PPARA activates gene expression 114 5.58e-01 0.031700 7.42e-01
Trafficking and processing of endosomal TLR 12 5.60e-01 0.097300 7.43e-01
Signalling to RAS 19 5.62e-01 0.076900 7.45e-01
SLC transporter disorders 95 5.62e-01 -0.034400 7.45e-01
Caspase activation via extrinsic apoptotic signalling pathway 21 5.63e-01 -0.072900 7.45e-01
FOXO-mediated transcription 64 5.64e-01 0.041700 7.47e-01
Reduction of cytosolic Ca++ levels 12 5.69e-01 0.094900 7.52e-01
FGFR1 ligand binding and activation 12 5.70e-01 -0.094700 7.52e-01
PKA activation 16 5.70e-01 0.082000 7.52e-01
Epigenetic regulation of gene expression 94 5.70e-01 0.033900 7.52e-01
The NLRP3 inflammasome 15 5.72e-01 0.084300 7.53e-01
Downregulation of ERBB2 signaling 26 5.72e-01 0.064000 7.53e-01
Sodium/Calcium exchangers 11 5.73e-01 0.098200 7.53e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 5.73e-01 0.065100 7.53e-01
The role of Nef in HIV-1 replication and disease pathogenesis 27 5.74e-01 0.062500 7.53e-01
SUMOylation of immune response proteins 10 5.77e-01 0.102000 7.55e-01
Signaling by the B Cell Receptor (BCR) 133 5.77e-01 0.028000 7.55e-01
Nuclear Receptor transcription pathway 53 5.78e-01 -0.044200 7.55e-01
Rev-mediated nuclear export of HIV RNA 34 5.78e-01 -0.055200 7.55e-01
PI3K events in ERBB4 signaling 10 5.80e-01 0.101000 7.57e-01
Activation of BAD and translocation to mitochondria 15 5.80e-01 0.082400 7.57e-01
Signal transduction by L1 21 5.81e-01 0.069600 7.57e-01
Deactivation of the beta-catenin transactivating complex 39 5.81e-01 -0.051000 7.57e-01
Sialic acid metabolism 31 5.82e-01 0.057200 7.57e-01
CD28 dependent PI3K/Akt signaling 22 5.84e-01 0.067500 7.59e-01
G-protein mediated events 51 5.84e-01 -0.044300 7.59e-01
Oncogene Induced Senescence 30 5.86e-01 -0.057400 7.61e-01
Prolonged ERK activation events 14 5.87e-01 0.083900 7.61e-01
ERBB2 Activates PTK6 Signaling 13 5.88e-01 -0.086900 7.61e-01
Incretin synthesis, secretion, and inactivation 20 5.88e-01 0.070000 7.61e-01
Pentose phosphate pathway 14 5.88e-01 0.083600 7.61e-01
NS1 Mediated Effects on Host Pathways 40 5.90e-01 -0.049300 7.62e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 103 5.93e-01 -0.030500 7.65e-01
Circadian Clock 68 5.93e-01 0.037500 7.65e-01
ERKs are inactivated 12 5.94e-01 0.088900 7.66e-01
Processing of Capped Intronless Pre-mRNA 26 5.96e-01 0.060000 7.68e-01
Signaling by NOTCH1 69 6.02e-01 0.036300 7.75e-01
Adenylate cyclase inhibitory pathway 14 6.03e-01 -0.080400 7.75e-01
Costimulation by the CD28 family 64 6.03e-01 0.037600 7.75e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 6.05e-01 0.082900 7.75e-01
ADORA2B mediated anti-inflammatory cytokines production 113 6.05e-01 -0.028200 7.75e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 78 6.06e-01 0.033800 7.75e-01
Killing mechanisms 12 6.06e-01 0.085900 7.75e-01
WNT5:FZD7-mediated leishmania damping 12 6.06e-01 0.085900 7.75e-01
Positive epigenetic regulation of rRNA expression 52 6.07e-01 0.041300 7.75e-01
Cell junction organization 85 6.07e-01 -0.032300 7.75e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 10 6.07e-01 0.093800 7.75e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 10 6.08e-01 -0.093600 7.75e-01
PI-3K cascade:FGFR1 18 6.09e-01 -0.069700 7.75e-01
SHC-mediated cascade:FGFR1 18 6.11e-01 -0.069200 7.78e-01
Disease 1431 6.12e-01 0.008070 7.78e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 31 6.15e-01 -0.052100 7.81e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 30 6.17e-01 -0.052800 7.83e-01
Negative regulation of MET activity 20 6.18e-01 0.064500 7.83e-01
Negative regulation of FGFR4 signaling 26 6.19e-01 0.056400 7.83e-01
PKA-mediated phosphorylation of CREB 18 6.23e-01 0.066900 7.89e-01
Selenoamino acid metabolism 92 6.25e-01 0.029500 7.90e-01
Signaling by ERBB4 53 6.26e-01 0.038700 7.91e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 6.28e-01 0.051100 7.93e-01
mRNA decay by 5' to 3' exoribonuclease 15 6.30e-01 -0.071800 7.95e-01
Signaling by NODAL 18 6.32e-01 -0.065200 7.96e-01
SHC1 events in ERBB2 signaling 22 6.33e-01 -0.058700 7.96e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 11 6.34e-01 0.083000 7.96e-01
Death Receptor Signalling 132 6.34e-01 -0.024000 7.96e-01
DAG and IP3 signaling 38 6.34e-01 -0.044600 7.96e-01
Kinesins 40 6.36e-01 -0.043300 7.96e-01
Blood group systems biosynthesis 18 6.38e-01 0.064100 7.96e-01
Eicosanoid ligand-binding receptors 13 6.39e-01 0.075000 7.96e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 49 6.39e-01 -0.038700 7.96e-01
PI3K events in ERBB2 signaling 16 6.40e-01 -0.067500 7.96e-01
Triglyceride metabolism 35 6.40e-01 0.045600 7.96e-01
ERK/MAPK targets 21 6.41e-01 0.058700 7.96e-01
AMER1 mutants destabilize the destruction complex 13 6.41e-01 0.074600 7.96e-01
APC truncation mutants have impaired AXIN binding 13 6.41e-01 0.074600 7.96e-01
AXIN missense mutants destabilize the destruction complex 13 6.41e-01 0.074600 7.96e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 13 6.41e-01 0.074600 7.96e-01
Truncations of AMER1 destabilize the destruction complex 13 6.41e-01 0.074600 7.96e-01
truncated APC mutants destabilize the destruction complex 13 6.41e-01 0.074600 7.96e-01
Signaling by NOTCH3 44 6.45e-01 0.040100 8.00e-01
NGF-stimulated transcription 36 6.47e-01 0.044100 8.02e-01
Response to elevated platelet cytosolic Ca2+ 128 6.48e-01 -0.023400 8.02e-01
SHC-mediated cascade:FGFR2 20 6.49e-01 0.058800 8.03e-01
Synthesis of PA 38 6.50e-01 -0.042600 8.03e-01
Signaling by KIT in disease 20 6.52e-01 0.058300 8.03e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 6.52e-01 0.058300 8.03e-01
G1/S Transition 127 6.52e-01 0.023200 8.03e-01
PI-3K cascade:FGFR2 20 6.52e-01 0.058300 8.03e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 30 6.52e-01 -0.047600 8.03e-01
Alpha-protein kinase 1 signaling pathway 10 6.55e-01 0.081600 8.05e-01
Peptide hormone biosynthesis 10 6.55e-01 0.081600 8.05e-01
Glutathione synthesis and recycling 12 6.57e-01 0.074100 8.06e-01
Golgi Cisternae Pericentriolar Stack Reorganization 12 6.58e-01 0.073800 8.07e-01
FGFR2c ligand binding and activation 11 6.58e-01 0.077000 8.07e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 26 6.60e-01 -0.049800 8.07e-01
Assembly of active LPL and LIPC lipase complexes 19 6.60e-01 -0.058200 8.07e-01
Major pathway of rRNA processing in the nucleolus and cytosol 157 6.61e-01 -0.020300 8.07e-01
NOTCH4 Intracellular Domain Regulates Transcription 18 6.61e-01 -0.059600 8.07e-01
LGI-ADAM interactions 13 6.62e-01 0.070100 8.07e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 43 6.62e-01 0.038500 8.07e-01
Dopamine Neurotransmitter Release Cycle 23 6.67e-01 0.051800 8.13e-01
Regulation of TP53 Activity 149 6.68e-01 -0.020400 8.13e-01
Mitotic Metaphase and Anaphase 218 6.69e-01 0.016800 8.14e-01
CTLA4 inhibitory signaling 21 6.70e-01 0.053700 8.14e-01
Gap junction assembly 16 6.70e-01 -0.061500 8.14e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 6.73e-01 0.067700 8.16e-01
Regulation of beta-cell development 36 6.79e-01 -0.039800 8.22e-01
RIPK1-mediated regulated necrosis 24 6.80e-01 -0.048700 8.22e-01
Regulated Necrosis 24 6.80e-01 -0.048700 8.22e-01
Regulation of necroptotic cell death 24 6.80e-01 -0.048700 8.22e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 10 6.82e-01 0.074700 8.24e-01
Phospholipase C-mediated cascade; FGFR2 15 6.83e-01 0.061000 8.24e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 71 6.83e-01 0.028000 8.24e-01
Signaling by FGFR3 36 6.84e-01 -0.039200 8.24e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 6.84e-01 -0.065100 8.24e-01
Downstream signaling of activated FGFR4 24 6.87e-01 -0.047500 8.26e-01
Metabolic disorders of biological oxidation enzymes 32 6.88e-01 -0.041000 8.26e-01
ERBB2 Regulates Cell Motility 15 6.88e-01 -0.059800 8.26e-01
Reversible hydration of carbon dioxide 12 6.89e-01 -0.066800 8.26e-01
Scavenging by Class A Receptors 17 6.90e-01 -0.056000 8.27e-01
Lewis blood group biosynthesis 14 6.93e-01 0.060900 8.29e-01
Mitotic Anaphase 217 6.93e-01 0.015600 8.29e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 6.93e-01 0.072000 8.29e-01
Neurotransmitter release cycle 48 6.94e-01 0.032900 8.29e-01
Signaling by Receptor Tyrosine Kinases 458 6.96e-01 -0.010700 8.31e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 19 6.99e-01 0.051300 8.33e-01
Neurodegenerative Diseases 19 6.99e-01 0.051300 8.33e-01
Protein folding 95 7.02e-01 0.022700 8.34e-01
Signaling by PDGFRA extracellular domain mutants 12 7.02e-01 0.063800 8.34e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 7.02e-01 0.063800 8.34e-01
M Phase 346 7.02e-01 -0.012000 8.34e-01
CRMPs in Sema3A signaling 16 7.03e-01 -0.055000 8.35e-01
PLC beta mediated events 50 7.05e-01 -0.030900 8.36e-01
Triglyceride catabolism 22 7.06e-01 0.046500 8.36e-01
Defects in cobalamin (B12) metabolism 14 7.09e-01 0.057700 8.39e-01
SHC1 events in ERBB4 signaling 14 7.11e-01 0.057200 8.41e-01
Receptor-type tyrosine-protein phosphatases 18 7.11e-01 0.050400 8.41e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 41 7.14e-01 -0.033100 8.44e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 22 7.16e-01 0.044900 8.45e-01
FGFR2 alternative splicing 22 7.19e-01 -0.044400 8.47e-01
Diseases of programmed cell death 25 7.19e-01 0.041600 8.47e-01
Signaling by ERBB2 TMD/JMD mutants 20 7.21e-01 -0.046100 8.49e-01
TICAM1, RIP1-mediated IKK complex recruitment 16 7.22e-01 0.051400 8.49e-01
Regulation of FZD by ubiquitination 19 7.24e-01 0.046900 8.51e-01
IGF1R signaling cascade 48 7.24e-01 -0.029400 8.51e-01
Maturation of nucleoprotein 10 7.25e-01 0.064300 8.51e-01
rRNA processing in the nucleus and cytosol 166 7.25e-01 -0.015800 8.51e-01
Signaling by PDGFR in disease 19 7.27e-01 0.046300 8.52e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 7.27e-01 -0.048800 8.52e-01
Vitamin D (calciferol) metabolism 11 7.29e-01 -0.060400 8.52e-01
FGFR4 ligand binding and activation 11 7.29e-01 0.060400 8.52e-01
DNA Damage Bypass 44 7.32e-01 0.029900 8.55e-01
MASTL Facilitates Mitotic Progression 10 7.32e-01 0.062500 8.55e-01
IRS-mediated signalling 44 7.33e-01 -0.029700 8.55e-01
Platelet calcium homeostasis 28 7.34e-01 -0.037100 8.55e-01
IKK complex recruitment mediated by RIP1 18 7.35e-01 0.046200 8.55e-01
Platelet homeostasis 82 7.36e-01 -0.021600 8.56e-01
Carboxyterminal post-translational modifications of tubulin 33 7.37e-01 0.033700 8.57e-01
RUNX2 regulates osteoblast differentiation 24 7.39e-01 0.039300 8.57e-01
Viral mRNA Translation 66 7.39e-01 0.023700 8.57e-01
Smooth Muscle Contraction 32 7.40e-01 0.033900 8.57e-01
Constitutive Signaling by EGFRvIII 14 7.40e-01 -0.051200 8.57e-01
Signaling by EGFRvIII in Cancer 14 7.40e-01 -0.051200 8.57e-01
Plasma lipoprotein assembly, remodeling, and clearance 68 7.42e-01 -0.023100 8.59e-01
Clathrin-mediated endocytosis 138 7.46e-01 0.016000 8.62e-01
IRS-related events triggered by IGF1R 47 7.47e-01 -0.027200 8.62e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 27 7.47e-01 -0.035900 8.62e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 13 7.48e-01 0.051400 8.63e-01
Pre-NOTCH Processing in Golgi 18 7.49e-01 -0.043500 8.63e-01
Estrogen-dependent gene expression 96 7.51e-01 0.018800 8.64e-01
Oncogenic MAPK signaling 78 7.51e-01 -0.020800 8.64e-01
Signaling by NTRK3 (TRKC) 17 7.53e-01 0.044000 8.66e-01
Cell-extracellular matrix interactions 16 7.55e-01 0.045100 8.67e-01
Synthesis of bile acids and bile salts 29 7.56e-01 0.033400 8.67e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 10 7.57e-01 0.056600 8.68e-01
Transport of Mature mRNA Derived from an Intronless Transcript 40 7.57e-01 -0.028200 8.68e-01
Transcriptional regulation of white adipocyte differentiation 81 7.60e-01 -0.019700 8.70e-01
Termination of translesion DNA synthesis 30 7.61e-01 -0.032200 8.70e-01
EGFR downregulation 30 7.61e-01 -0.032100 8.70e-01
Post-chaperonin tubulin folding pathway 18 7.63e-01 -0.041100 8.71e-01
Regulation of MECP2 expression and activity 29 7.67e-01 0.031900 8.75e-01
MET activates RAS signaling 11 7.69e-01 -0.051200 8.75e-01
Signaling by FGFR4 36 7.69e-01 -0.028200 8.75e-01
Translocation of ZAP-70 to Immunological synapse 14 7.70e-01 0.045200 8.75e-01
CS/DS degradation 14 7.71e-01 -0.044900 8.75e-01
GP1b-IX-V activation signalling 10 7.71e-01 -0.053100 8.75e-01
Signaling by WNT in cancer 33 7.72e-01 -0.029100 8.75e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 7.72e-01 0.044700 8.75e-01
Phase 2 - plateau phase 15 7.73e-01 -0.043000 8.75e-01
Mismatch Repair 14 7.73e-01 0.044500 8.75e-01
Defensins 21 7.74e-01 0.036300 8.75e-01
FRS-mediated FGFR2 signaling 22 7.74e-01 0.035400 8.75e-01
Activated NTRK2 signals through FRS2 and FRS3 11 7.74e-01 0.049900 8.75e-01
Signaling by ERBB2 47 7.76e-01 -0.024000 8.76e-01
Insulin processing 27 7.78e-01 -0.031300 8.78e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 19 7.79e-01 0.037100 8.79e-01
Negative regulation of FGFR3 signaling 25 7.81e-01 0.032200 8.80e-01
Chaperonin-mediated protein folding 89 7.82e-01 0.017000 8.81e-01
Triglyceride biosynthesis 13 7.84e-01 0.044000 8.82e-01
Gap junction trafficking and regulation 26 7.84e-01 -0.031000 8.82e-01
Eukaryotic Translation Termination 70 7.85e-01 0.018900 8.82e-01
Synthesis of PC 27 7.87e-01 -0.030100 8.83e-01
Acyl chain remodelling of PG 17 7.87e-01 0.037800 8.83e-01
EPH-ephrin mediated repulsion of cells 48 7.88e-01 0.022400 8.83e-01
Caspase activation via Dependence Receptors in the absence of ligand 10 7.91e-01 0.048500 8.85e-01
P2Y receptors 11 7.91e-01 -0.046000 8.86e-01
Transcriptional regulation of pluripotent stem cells 28 7.93e-01 0.028700 8.86e-01
Formation of the cornified envelope 35 7.94e-01 0.025600 8.87e-01
Sema4D in semaphorin signaling 24 7.98e-01 -0.030200 8.91e-01
Downregulation of ERBB2:ERBB3 signaling 12 7.99e-01 0.042400 8.92e-01
Interleukin-2 signaling 12 8.00e-01 -0.042300 8.92e-01
BBSome-mediated cargo-targeting to cilium 22 8.01e-01 0.031100 8.92e-01
Chromatin modifying enzymes 208 8.02e-01 0.010100 8.92e-01
Chromatin organization 208 8.02e-01 0.010100 8.92e-01
Regulation of gene expression by Hypoxia-inducible Factor 11 8.04e-01 0.043200 8.93e-01
Integrin signaling 27 8.06e-01 -0.027300 8.95e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 12 8.09e-01 0.040400 8.97e-01
RUNX3 regulates NOTCH signaling 12 8.10e-01 -0.040100 8.98e-01
Inflammasomes 20 8.12e-01 0.030700 8.99e-01
Regulated proteolysis of p75NTR 11 8.13e-01 0.041300 8.99e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 22 8.13e-01 0.029200 8.99e-01
Signaling by EGFR 49 8.14e-01 -0.019400 9.00e-01
SHC-mediated cascade:FGFR4 17 8.15e-01 0.032700 9.01e-01
Peptide hormone metabolism 81 8.17e-01 -0.014900 9.02e-01
PI-3K cascade:FGFR4 17 8.19e-01 0.032100 9.02e-01
Translesion synthesis by POLI 16 8.19e-01 0.033100 9.02e-01
Nuclear Envelope (NE) Reassembly 64 8.20e-01 0.016500 9.03e-01
PECAM1 interactions 11 8.22e-01 -0.039300 9.04e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 29 8.26e-01 0.023600 9.08e-01
Synaptic adhesion-like molecules 21 8.28e-01 -0.027300 9.10e-01
Antimicrobial peptides 47 8.30e-01 0.018100 9.11e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 8.31e-01 0.039100 9.11e-01
RHO GTPases activate IQGAPs 11 8.32e-01 0.037000 9.12e-01
Fatty acyl-CoA biosynthesis 35 8.33e-01 0.020600 9.13e-01
FRS-mediated FGFR3 signaling 18 8.37e-01 -0.028000 9.15e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 35 8.38e-01 0.020000 9.15e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 23 8.39e-01 0.024500 9.15e-01
NOTCH2 intracellular domain regulates transcription 10 8.39e-01 -0.037100 9.15e-01
Translesion Synthesis by POLH 16 8.39e-01 0.029300 9.15e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 8.41e-01 -0.022800 9.15e-01
Degradation of cysteine and homocysteine 11 8.41e-01 0.035000 9.15e-01
Fanconi Anemia Pathway 35 8.42e-01 -0.019500 9.15e-01
COPI-dependent Golgi-to-ER retrograde traffic 79 8.42e-01 0.012900 9.15e-01
Platelet degranulation 123 8.42e-01 -0.010400 9.15e-01
Purine catabolism 17 8.44e-01 0.027600 9.15e-01
Regulation of TP53 Activity through Association with Co-factors 13 8.44e-01 -0.031600 9.15e-01
PCNA-Dependent Long Patch Base Excision Repair 20 8.44e-01 -0.025500 9.15e-01
PI3K Cascade 40 8.44e-01 -0.018000 9.15e-01
Selenocysteine synthesis 69 8.45e-01 -0.013600 9.15e-01
Oxidative Stress Induced Senescence 69 8.46e-01 0.013500 9.16e-01
Generation of second messenger molecules 28 8.48e-01 0.020900 9.16e-01
Phospholipase C-mediated cascade; FGFR3 11 8.48e-01 -0.033300 9.16e-01
Factors involved in megakaryocyte development and platelet production 124 8.49e-01 -0.009940 9.16e-01
Myogenesis 28 8.49e-01 -0.020800 9.16e-01
MET activates PTK2 signaling 18 8.52e-01 -0.025500 9.18e-01
Laminin interactions 23 8.57e-01 -0.021800 9.21e-01
Metabolism of non-coding RNA 51 8.57e-01 0.014600 9.21e-01
snRNP Assembly 51 8.57e-01 0.014600 9.21e-01
Recognition of DNA damage by PCNA-containing replication complex 28 8.58e-01 0.019600 9.21e-01
E3 ubiquitin ligases ubiquitinate target proteins 46 8.58e-01 -0.015300 9.21e-01
Beta-catenin phosphorylation cascade 16 8.61e-01 0.025200 9.23e-01
Phosphorylation of CD3 and TCR zeta chains 17 8.62e-01 0.024400 9.23e-01
Downstream signaling of activated FGFR2 27 8.62e-01 -0.019300 9.23e-01
Disorders of Developmental Biology 13 8.64e-01 -0.027400 9.23e-01
Disorders of Nervous System Development 13 8.64e-01 -0.027400 9.23e-01
Loss of function of MECP2 in Rett syndrome 13 8.64e-01 -0.027400 9.23e-01
Pervasive developmental disorders 13 8.64e-01 -0.027400 9.23e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 8.66e-01 0.030700 9.25e-01
Deadenylation of mRNA 20 8.67e-01 0.021600 9.25e-01
Processing of Intronless Pre-mRNAs 18 8.72e-01 0.022000 9.30e-01
Recycling pathway of L1 27 8.73e-01 0.017800 9.30e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 90 8.75e-01 0.009570 9.31e-01
Nonsense-Mediated Decay (NMD) 90 8.75e-01 0.009570 9.31e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 8.76e-01 0.017400 9.31e-01
Signaling by FGFR2 62 8.78e-01 -0.011300 9.33e-01
SRP-dependent cotranslational protein targeting to membrane 89 8.80e-01 -0.009230 9.35e-01
Synthesis of very long-chain fatty acyl-CoAs 24 8.82e-01 -0.017500 9.35e-01
Phospholipase C-mediated cascade; FGFR4 12 8.82e-01 0.024700 9.35e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 41 8.83e-01 -0.013200 9.36e-01
Platelet Adhesion to exposed collagen 13 8.84e-01 -0.023400 9.36e-01
Signaling by Insulin receptor 73 8.87e-01 0.009580 9.38e-01
FGFR3 ligand binding and activation 11 8.88e-01 0.024500 9.38e-01
FGFR3c ligand binding and activation 11 8.88e-01 0.024500 9.38e-01
Platelet Aggregation (Plug Formation) 37 8.89e-01 -0.013300 9.38e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 17 8.91e-01 0.019200 9.38e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 17 8.91e-01 0.019200 9.38e-01
Cargo trafficking to the periciliary membrane 49 8.91e-01 -0.011300 9.38e-01
Nephrin family interactions 21 8.92e-01 -0.017200 9.38e-01
Peptide chain elongation 66 8.94e-01 0.009510 9.40e-01
Keratan sulfate degradation 12 8.96e-01 -0.021800 9.41e-01
eNOS activation 10 8.97e-01 -0.023700 9.42e-01
Viral Messenger RNA Synthesis 41 8.98e-01 0.011600 9.42e-01
Interleukin-12 signaling 40 8.98e-01 0.011700 9.42e-01
Signaling by Nuclear Receptors 235 9.01e-01 -0.004720 9.44e-01
Initiation of Nuclear Envelope (NE) Reformation 16 9.04e-01 0.017400 9.47e-01
NOTCH1 Intracellular Domain Regulates Transcription 43 9.05e-01 -0.010600 9.47e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 11 9.08e-01 -0.020100 9.47e-01
Mitotic G1 phase and G1/S transition 143 9.09e-01 0.005550 9.47e-01
Signaling by BRAF and RAF fusions 61 9.11e-01 0.008320 9.47e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 42 9.11e-01 0.010000 9.47e-01
Signaling by RAS mutants 42 9.11e-01 0.010000 9.47e-01
Signaling by moderate kinase activity BRAF mutants 42 9.11e-01 0.010000 9.47e-01
Signaling downstream of RAS mutants 42 9.11e-01 0.010000 9.47e-01
Vasopressin regulates renal water homeostasis via Aquaporins 41 9.11e-01 -0.010100 9.47e-01
Negative regulation of FGFR1 signaling 27 9.11e-01 -0.012400 9.47e-01
Regulation of IFNG signaling 14 9.12e-01 0.017000 9.47e-01
Axon guidance 490 9.13e-01 0.002910 9.47e-01
Metabolism of folate and pterines 17 9.16e-01 0.014900 9.49e-01
Neurotransmitter receptors and postsynaptic signal transmission 172 9.16e-01 -0.004690 9.49e-01
Synthesis, secretion, and deacylation of Ghrelin 18 9.17e-01 -0.014100 9.50e-01
Separation of Sister Chromatids 165 9.19e-01 0.004570 9.52e-01
Nervous system development 513 9.20e-01 0.002590 9.52e-01
Early Phase of HIV Life Cycle 13 9.25e-01 -0.015000 9.56e-01
Acyl chain remodelling of PS 21 9.29e-01 -0.011300 9.59e-01
Activation of BH3-only proteins 27 9.29e-01 0.009910 9.59e-01
RUNX2 regulates bone development 30 9.32e-01 0.009040 9.61e-01
Regulation of RUNX1 Expression and Activity 23 9.37e-01 -0.009580 9.63e-01
Trafficking of GluR2-containing AMPA receptors 17 9.37e-01 -0.011100 9.63e-01
Gamma-carboxylation of protein precursors 10 9.38e-01 -0.014300 9.63e-01
PERK regulates gene expression 31 9.38e-01 -0.008090 9.63e-01
CaM pathway 32 9.38e-01 0.007950 9.63e-01
Calmodulin induced events 32 9.38e-01 0.007950 9.63e-01
Aquaporin-mediated transport 49 9.39e-01 0.006330 9.64e-01
mRNA Splicing - Minor Pathway 48 9.40e-01 -0.006240 9.64e-01
Translesion synthesis by POLK 16 9.40e-01 0.010800 9.64e-01
Interconversion of nucleotide di- and triphosphates 28 9.44e-01 -0.007740 9.66e-01
Pyrimidine catabolism 12 9.48e-01 -0.010900 9.70e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 18 9.49e-01 0.008780 9.70e-01
FRS-mediated FGFR4 signaling 19 9.50e-01 0.008370 9.70e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 9.50e-01 0.010900 9.70e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 13 9.51e-01 -0.009840 9.70e-01
PI-3K cascade:FGFR3 16 9.60e-01 -0.007270 9.79e-01
Gap junction trafficking 24 9.62e-01 0.005650 9.80e-01
Cell-Cell communication 117 9.63e-01 -0.002500 9.80e-01
SHC-mediated cascade:FGFR3 16 9.63e-01 -0.006650 9.80e-01
tRNA processing in the nucleus 57 9.64e-01 0.003490 9.80e-01
Ca-dependent events 34 9.65e-01 -0.004380 9.80e-01
RAB geranylgeranylation 60 9.66e-01 -0.003190 9.81e-01
Gene Silencing by RNA 84 9.69e-01 -0.002440 9.83e-01
Protein ubiquitination 65 9.69e-01 0.002760 9.83e-01
Translesion synthesis by REV1 15 9.76e-01 0.004540 9.89e-01
Signaling by RAF1 mutants 38 9.80e-01 -0.002370 9.92e-01
Transmission across Chemical Synapses 234 9.81e-01 0.000910 9.93e-01
Opioid Signalling 87 9.82e-01 0.001400 9.93e-01
Diseases of metabolism 228 9.84e-01 0.000781 9.94e-01
Tie2 Signaling 18 9.86e-01 0.002310 9.95e-01
Cytosolic sulfonation of small molecules 23 9.87e-01 -0.001990 9.95e-01
p38MAPK events 13 9.87e-01 0.002550 9.95e-01
RAS processing 19 9.88e-01 0.002020 9.95e-01
GRB2 events in ERBB2 signaling 16 9.89e-01 0.001980 9.95e-01
SUMOylation of transcription cofactors 43 9.91e-01 0.001030 9.95e-01
Regulation of gene expression in beta cells 19 9.91e-01 0.001490 9.95e-01
S Phase 157 9.91e-01 0.000515 9.95e-01
Sema4D induced cell migration and growth-cone collapse 20 9.91e-01 0.001400 9.95e-01
Nicotinate metabolism 31 9.92e-01 -0.001010 9.96e-01
Phase 0 - rapid depolarisation 30 9.95e-01 0.000603 9.98e-01
Sulfur amino acid metabolism 25 9.96e-01 0.000575 9.98e-01
Apoptotic cleavage of cellular proteins 38 9.98e-01 -0.000284 9.99e-01
FGFR3 mutant receptor activation 10 9.99e-01 0.000147 9.99e-01
Signaling by activated point mutants of FGFR3 10 9.99e-01 0.000147 9.99e-01


Detailed Gene set reports



Mitochondrial translation elongation

Mitochondrial translation elongation
710
set Mitochondrial translation elongation
setSize 85
pANOVA 6.41e-21
s.dist 0.588
p.adjustANOVA 7.06e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPS18B 9007.5
PTCD3 8917.5
MRPL30 8739.0
MRPL38 8381.5
MRPL37 8373.5
GFM1 8370.5
MRPS34 8288.5
MRPL10 8203.5
MRPL36 8147.5
MRPS5 8097.5
MRPS17 7940.0
MRPL4 7909.5
MRPL12 7898.5
MRPL28 7858.5
MRPL45 7805.5
TSFM 7754.5
MRPS15 7718.5
MRPL1 7666.5
MRPS30 7513.5
MRPL9 7452.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS18B 9007.5
PTCD3 8917.5
MRPL30 8739.0
MRPL38 8381.5
MRPL37 8373.5
GFM1 8370.5
MRPS34 8288.5
MRPL10 8203.5
MRPL36 8147.5
MRPS5 8097.5
MRPS17 7940.0
MRPL4 7909.5
MRPL12 7898.5
MRPL28 7858.5
MRPL45 7805.5
TSFM 7754.5
MRPS15 7718.5
MRPL1 7666.5
MRPS30 7513.5
MRPL9 7452.5
MRPL19 7446.5
MRPL44 7423.5
TUFM 7412.5
OXA1L 7295.5
MRPL14 7233.5
MRPL42 7151.5
MRPL58 7145.5
MRPS9 7125.5
MRPS21 7123.5
MRPL33 7108.5
MRPL46 7097.5
MRPS2 7088.5
MRPL15 7081.5
MRPS14 7080.5
MRPS23 7023.5
MRPL34 7010.5
DAP3 6808.5
MRPL53 6767.5
MRPL39 6593.5
MRPL17 6570.5
MRPL11 6448.5
MRPL54 6383.5
MRPS6 6299.5
MRPL47 6290.5
MRPS18A 6180.5
MRPL50 6063.5
MRPS24 6060.5
MRPL24 6022.5
MRPL13 5793.5
MRPL3 5792.5
MRPS7 5442.5
MRPL22 5316.5
GADD45GIP1 5315.5
MRPL49 5221.5
MRPL55 5154.5
MRPS26 5107.5
MRPS11 5060.5
MRPL2 4996.5
MRPS12 4860.5
MRPL35 4577.5
MRPL20 4398.5
MRPL52 4008.5
MRPL32 3649.5
MRPS27 3638.5
MRPS31 3476.5
MRPL40 3261.5
MRPS18C 3041.5
ERAL1 2960.5
MRPS10 2736.5
MRPS22 2728.5
MRPS33 2646.5
CHCHD1 2605.5
MRPL18 2121.5
MRPS25 1771.5
MRPL21 1681.5
MRPL41 1669.5
MRPL16 1300.5
MRPL51 1260.5
MRPL48 1028.5
MRPL43 -1166.5
MRPS16 -1420.5
MRPL27 -1728.5
MRPS28 -1815.5
MRPS35 -2568.5
MRPS36 -2886.5


Mitochondrial translation

Mitochondrial translation
709
set Mitochondrial translation
setSize 91
pANOVA 9.76e-21
s.dist 0.566
p.adjustANOVA 7.06e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPS18B 9007.5
PTCD3 8917.5
MRPL30 8739.0
MRPL38 8381.5
MRPL37 8373.5
GFM1 8370.5
GFM2 8363.5
MRPS34 8288.5
MRPL10 8203.5
MRPL36 8147.5
MRPS5 8097.5
MRPS17 7940.0
MRPL4 7909.5
MRPL12 7898.5
MRPL28 7858.5
MRPL45 7805.5
TSFM 7754.5
MRPS15 7718.5
MRPL1 7666.5
MRPS30 7513.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS18B 9007.5
PTCD3 8917.5
MRPL30 8739.0
MRPL38 8381.5
MRPL37 8373.5
GFM1 8370.5
GFM2 8363.5
MRPS34 8288.5
MRPL10 8203.5
MRPL36 8147.5
MRPS5 8097.5
MRPS17 7940.0
MRPL4 7909.5
MRPL12 7898.5
MRPL28 7858.5
MRPL45 7805.5
TSFM 7754.5
MRPS15 7718.5
MRPL1 7666.5
MRPS30 7513.5
MRPL9 7452.5
MRPL19 7446.5
MRPL44 7423.5
TUFM 7412.5
OXA1L 7295.5
MRPL14 7233.5
MRPL42 7151.5
MRPL58 7145.5
MRPS9 7125.5
MRPS21 7123.5
MRPL33 7108.5
MRPL46 7097.5
MRPS2 7088.5
MRPL15 7081.5
MRPS14 7080.5
MRPS23 7023.5
MRPL34 7010.5
DAP3 6808.5
MRPL53 6767.5
MRPL39 6593.5
MRPL17 6570.5
MRPL11 6448.5
MRPL54 6383.5
MRPS6 6299.5
MRPL47 6290.5
MRPS18A 6180.5
MRPL50 6063.5
MRPS24 6060.5
MRPL24 6022.5
MRPL13 5793.5
MRPL3 5792.5
MRPS7 5442.5
MRPL22 5316.5
GADD45GIP1 5315.5
MRPL49 5221.5
MRPL55 5154.5
MRPS26 5107.5
MRPS11 5060.5
MRPL2 4996.5
MRPS12 4860.5
MRPL35 4577.5
MRPL20 4398.5
MRPL52 4008.5
MRPL32 3649.5
MRPS27 3638.5
MRPS31 3476.5
MRRF 3438.5
MRPL40 3261.5
MRPS18C 3041.5
MTRF1L 3028.5
ERAL1 2960.5
MTIF2 2857.5
MRPS10 2736.5
MRPS22 2728.5
MRPS33 2646.5
CHCHD1 2605.5
MRPL18 2121.5
MTIF3 2088.5
MRPS25 1771.5
MRPL21 1681.5
MRPL41 1669.5
MRPL16 1300.5
MRPL51 1260.5
MRPL48 1028.5
MRPL43 -1166.5
MRPS16 -1420.5
MRPL27 -1728.5
MRPS28 -1815.5
MRPS35 -2568.5
MRPS36 -2886.5
MTFMT -5744.5


Mitochondrial translation termination

Mitochondrial translation termination
712
set Mitochondrial translation termination
setSize 85
pANOVA 3.68e-20
s.dist 0.577
p.adjustANOVA 1.77e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPS18B 9007.5
PTCD3 8917.5
MRPL30 8739.0
MRPL38 8381.5
MRPL37 8373.5
GFM2 8363.5
MRPS34 8288.5
MRPL10 8203.5
MRPL36 8147.5
MRPS5 8097.5
MRPS17 7940.0
MRPL4 7909.5
MRPL12 7898.5
MRPL28 7858.5
MRPL45 7805.5
MRPS15 7718.5
MRPL1 7666.5
MRPS30 7513.5
MRPL9 7452.5
MRPL19 7446.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS18B 9007.5
PTCD3 8917.5
MRPL30 8739.0
MRPL38 8381.5
MRPL37 8373.5
GFM2 8363.5
MRPS34 8288.5
MRPL10 8203.5
MRPL36 8147.5
MRPS5 8097.5
MRPS17 7940.0
MRPL4 7909.5
MRPL12 7898.5
MRPL28 7858.5
MRPL45 7805.5
MRPS15 7718.5
MRPL1 7666.5
MRPS30 7513.5
MRPL9 7452.5
MRPL19 7446.5
MRPL44 7423.5
OXA1L 7295.5
MRPL14 7233.5
MRPL42 7151.5
MRPL58 7145.5
MRPS9 7125.5
MRPS21 7123.5
MRPL33 7108.5
MRPL46 7097.5
MRPS2 7088.5
MRPL15 7081.5
MRPS14 7080.5
MRPS23 7023.5
MRPL34 7010.5
DAP3 6808.5
MRPL53 6767.5
MRPL39 6593.5
MRPL17 6570.5
MRPL11 6448.5
MRPL54 6383.5
MRPS6 6299.5
MRPL47 6290.5
MRPS18A 6180.5
MRPL50 6063.5
MRPS24 6060.5
MRPL24 6022.5
MRPL13 5793.5
MRPL3 5792.5
MRPS7 5442.5
MRPL22 5316.5
GADD45GIP1 5315.5
MRPL49 5221.5
MRPL55 5154.5
MRPS26 5107.5
MRPS11 5060.5
MRPL2 4996.5
MRPS12 4860.5
MRPL35 4577.5
MRPL20 4398.5
MRPL52 4008.5
MRPL32 3649.5
MRPS27 3638.5
MRPS31 3476.5
MRRF 3438.5
MRPL40 3261.5
MRPS18C 3041.5
MTRF1L 3028.5
ERAL1 2960.5
MRPS10 2736.5
MRPS22 2728.5
MRPS33 2646.5
CHCHD1 2605.5
MRPL18 2121.5
MRPS25 1771.5
MRPL21 1681.5
MRPL41 1669.5
MRPL16 1300.5
MRPL51 1260.5
MRPL48 1028.5
MRPL43 -1166.5
MRPS16 -1420.5
MRPL27 -1728.5
MRPS28 -1815.5
MRPS35 -2568.5
MRPS36 -2886.5


Translation

Translation
1343
set Translation
setSize 263
pANOVA 2.86e-19
s.dist 0.322
p.adjustANOVA 1.03e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPS18B 9007.5
PTCD3 8917.5
VARS1 8908.5
RPL13A 8886.5
VARS2 8870.5
IARS2 8848.5
NARS1 8747.5
MRPL30 8739.0
IARS1 8710.5
FARS2 8703.5
NARS2 8624.5
RPLP2 8590.5
EIF4G1 8580.5
GSPT1 8520.5
LARS2 8505.5
MRPL38 8381.5
MRPL37 8373.5
GFM1 8370.5
GFM2 8363.5
MRPS34 8288.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS18B 9007.5
PTCD3 8917.5
VARS1 8908.5
RPL13A 8886.5
VARS2 8870.5
IARS2 8848.5
NARS1 8747.5
MRPL30 8739.0
IARS1 8710.5
FARS2 8703.5
NARS2 8624.5
RPLP2 8590.5
EIF4G1 8580.5
GSPT1 8520.5
LARS2 8505.5
MRPL38 8381.5
MRPL37 8373.5
GFM1 8370.5
GFM2 8363.5
MRPS34 8288.5
MRPL10 8203.5
SEC61G 8169.5
MRPL36 8147.5
MRPS5 8097.5
RPS9 7978.5
MARS2 7972.5
EIF2B5 7944.5
MRPS17 7940.0
AARS1 7920.5
MRPL4 7909.5
MRPL12 7898.5
MRPL28 7858.5
WARS1 7854.5
MRPL45 7805.5
EEF2 7789.5
EPRS1 7782.5
TSFM 7754.5
MRPS15 7718.5
MRPL1 7666.5
EIF4E 7655.5
EIF3K 7589.5
MRPS30 7513.5
HARS2 7498.5
EEF1G 7481.5
MRPL9 7452.5
MRPL19 7446.5
MRPL44 7423.5
TUFM 7412.5
UBA52 7357.5
OXA1L 7295.5
AIMP2 7246.5
MRPL14 7233.5
MRPL42 7151.5
MRPL58 7145.5
MRPS9 7125.5
MRPS21 7123.5
MRPL33 7108.5
DARS2 7106.5
MRPL46 7097.5
MRPS2 7088.5
MRPL15 7081.5
MRPS14 7080.5
EEF1A2 7029.5
MRPS23 7023.5
MRPL34 7010.5
EEF1D 6906.5
DAP3 6808.5
RPL28 6806.5
EIF3C 6805.0
EARS2 6792.5
MRPL53 6767.5
RPL19 6608.5
MRPL39 6593.5
MRPL17 6570.5
EIF4A2 6546.5
RPL29 6487.5
RPS10 6457.0
KARS1 6454.5
MRPL11 6448.5
MRPL54 6383.5
RPN2 6347.5
N6AMT1 6322.5
RPS11 6306.5
MRPS6 6299.5
MRPL47 6290.5
EIF2B1 6227.5
EIF5B 6216.5
MRPS18A 6180.5
SRP68 6138.5
MRPL50 6063.5
MRPS24 6060.5
MRPL24 6022.5
RPL35 5961.5
RPL13 5882.5
MARS1 5857.5
MRPL13 5793.5
MRPL3 5792.5
EIF3G 5745.5
PPA1 5736.5
AARS2 5661.5
RPSA 5610.5
EIF2B2 5602.5
EIF3L 5597.5
SEC11C 5517.5
RPS14 5480.5
MRPS7 5442.5
TARS2 5405.5
EIF3J 5336.5
MRPL22 5316.5
GADD45GIP1 5315.5
RPS7 5274.5
MRPL49 5221.5
RPL3L 5191.5
MRPL55 5154.5
MRPS26 5107.5
MRPS11 5060.5
MRPL2 4996.5
RPL18 4957.5
RPL10A 4938.5
MRPS12 4860.5
EIF2S2 4761.5
RPL18A 4656.5
MRPL35 4577.5
RPL9 4522.5
GARS1 4498.5
DDOST 4494.5
RPS4X 4442.5
RARS2 4410.5
MRPL20 4398.5
YARS1 4257.5
RPL15 4191.5
CARS1 4157.5
ETF1 4118.5
HARS1 4044.5
MRPL52 4008.5
SRPRA 3989.5
SARS2 3976.0
EIF3B 3961.5
TARS1 3797.5
EIF3H 3755.5
MRPL32 3649.5
MRPS27 3638.5
SSR4 3584.5
MRPS31 3476.5
APEH 3470.5
MRRF 3438.5
EIF2B4 3425.5
RPS26 3411.5
EIF4EBP1 3336.5
MRPL40 3261.5
RPS6 3167.5
FARSA 3117.5
RPL23 3101.5
EIF3A 3054.5
MRPS18C 3041.5
MTRF1L 3028.5
EIF2S3 3002.0
ERAL1 2960.5
EIF3D 2883.5
MTIF2 2857.5
SPCS1 2770.5
MRPS10 2736.5
MRPS22 2728.5
AIMP1 2707.5
MRPS33 2646.5
CHCHD1 2605.5
RPL8 2340.5
RPS27A 2261.5
PARS2 2174.5
MRPL18 2121.5
MTIF3 2088.5
RPL24 2057.5
RPS5 2028.5
SRP14 1989.5
QARS1 1901.5
EIF1AX 1826.5
RPL22 1825.5
SSR3 1807.5
MRPS25 1771.5
SARS1 1720.5
MRPL21 1681.5
MRPL41 1669.5
SRP9 1648.5
RPN1 1646.5
FARSB 1504.5
RARS1 1477.5
MRPL16 1300.5
MRPL51 1260.5
SPCS2 1231.5
CARS2 1179.5
RPS8 1133.5
RPS27L 1090.5
MRPL48 1028.5
EIF3E 897.5
SRP19 616.5
LARS1 552.5
RPS15 545.5
RPL37 367.5
RPL37A 302.5
RPS3A 133.5
RPL21 45.0
RPL32 0.5
RPS28 -86.5
MRPL43 -1166.5
EEF1B2 -1217.5
YARS2 -1276.5
MRPS16 -1420.5
RPL36 -1676.5
RPL31 -1702.5
MRPL27 -1728.5
MRPS28 -1815.5
SRP54 -1887.5
DARS1 -1997.5
EIF4A1 -2162.5
EIF2B3 -2357.5
RPL7A -2363.5
SEC61A1 -2411.5
MRPS35 -2568.5
RPS23 -2786.5
MRPS36 -2886.5
EIF3F -2965.5
SEC11A -3017.5
WARS2 -3221.5
RPL7 -3262.5
SPCS3 -3307.5
RPS3 -3309.5
RPS2 -3580.5
EEF1A1 -3659.5
EIF2S1 -4178.5
RPL5 -4208.5
RPS15A -4306.5
EIF5 -4315.5
RPS25 -4440.5
RPL10L -4738.5
TRMT112 -4815.5
EIF3M -4836.5
RPL38 -4919.5
RPL35A -4964.5
SSR2 -5139.5
SEC61B -5336.5
SRPRB -5708.5
SEC61A2 -5711.5
MTFMT -5744.5
RPL27 -5778.5
PPA2 -5799.5
EEF1E1 -6270.0
RPS18 -6410.5
RPS19 -6473.5
TRAM1 -6569.5
EIF4H -6631.5
RPL30 -6652.5
RPS21 -6677.5
RPLP1 -6712.5
GSPT2 -6727.5
FAU -6841.5
RPS17 -7220.5
RPL3 -7355.5
RPS16 -7482.5
SRP72 -7684.5
RPL6 -7781.5
RPL23A -8061.5
SSR1 -8085.5
RPS13 -8475.5


Mitochondrial translation initiation

Mitochondrial translation initiation
711
set Mitochondrial translation initiation
setSize 85
pANOVA 7.75e-19
s.dist 0.556
p.adjustANOVA 2.24e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPS18B 9007.5
PTCD3 8917.5
MRPL30 8739.0
MRPL38 8381.5
MRPL37 8373.5
MRPS34 8288.5
MRPL10 8203.5
MRPL36 8147.5
MRPS5 8097.5
MRPS17 7940.0
MRPL4 7909.5
MRPL12 7898.5
MRPL28 7858.5
MRPL45 7805.5
MRPS15 7718.5
MRPL1 7666.5
MRPS30 7513.5
MRPL9 7452.5
MRPL19 7446.5
MRPL44 7423.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS18B 9007.5
PTCD3 8917.5
MRPL30 8739.0
MRPL38 8381.5
MRPL37 8373.5
MRPS34 8288.5
MRPL10 8203.5
MRPL36 8147.5
MRPS5 8097.5
MRPS17 7940.0
MRPL4 7909.5
MRPL12 7898.5
MRPL28 7858.5
MRPL45 7805.5
MRPS15 7718.5
MRPL1 7666.5
MRPS30 7513.5
MRPL9 7452.5
MRPL19 7446.5
MRPL44 7423.5
OXA1L 7295.5
MRPL14 7233.5
MRPL42 7151.5
MRPL58 7145.5
MRPS9 7125.5
MRPS21 7123.5
MRPL33 7108.5
MRPL46 7097.5
MRPS2 7088.5
MRPL15 7081.5
MRPS14 7080.5
MRPS23 7023.5
MRPL34 7010.5
DAP3 6808.5
MRPL53 6767.5
MRPL39 6593.5
MRPL17 6570.5
MRPL11 6448.5
MRPL54 6383.5
MRPS6 6299.5
MRPL47 6290.5
MRPS18A 6180.5
MRPL50 6063.5
MRPS24 6060.5
MRPL24 6022.5
MRPL13 5793.5
MRPL3 5792.5
MRPS7 5442.5
MRPL22 5316.5
GADD45GIP1 5315.5
MRPL49 5221.5
MRPL55 5154.5
MRPS26 5107.5
MRPS11 5060.5
MRPL2 4996.5
MRPS12 4860.5
MRPL35 4577.5
MRPL20 4398.5
MRPL52 4008.5
MRPL32 3649.5
MRPS27 3638.5
MRPS31 3476.5
MRPL40 3261.5
MRPS18C 3041.5
ERAL1 2960.5
MTIF2 2857.5
MRPS10 2736.5
MRPS22 2728.5
MRPS33 2646.5
CHCHD1 2605.5
MRPL18 2121.5
MTIF3 2088.5
MRPS25 1771.5
MRPL21 1681.5
MRPL41 1669.5
MRPL16 1300.5
MRPL51 1260.5
MRPL48 1028.5
MRPL43 -1166.5
MRPS16 -1420.5
MRPL27 -1728.5
MRPS28 -1815.5
MRPS35 -2568.5
MRPS36 -2886.5
MTFMT -5744.5


The citric acid (TCA) cycle and respiratory electron transport

The citric acid (TCA) cycle and respiratory electron transport
1303
set The citric acid (TCA) cycle and respiratory electron transport
setSize 165
pANOVA 3.56e-13
s.dist 0.328
p.adjustANOVA 8.58e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACO2 8817.5
NDUFA12 8677.5
ATP5F1D 8640.5
PDP1 8638.5
NDUFA8 8607.5
PDHX 8564.5
ATP5PB 8530.5
NDUFS5 8426.5
PDHB 8238.5
BSG 8186.5
ECSIT 8154.5
DLST 8106.5
COX11 8096.5
ACAD9 8063.5
ME3 8005.5
FAHD1 7997.5
NDUFS7 7874.5
MT-CO1 7459.5
LDHB 7435.0
IDH2 7427.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACO2 8817.5
NDUFA12 8677.5
ATP5F1D 8640.5
PDP1 8638.5
NDUFA8 8607.5
PDHX 8564.5
ATP5PB 8530.5
NDUFS5 8426.5
PDHB 8238.5
BSG 8186.5
ECSIT 8154.5
DLST 8106.5
COX11 8096.5
ACAD9 8063.5
ME3 8005.5
FAHD1 7997.5
NDUFS7 7874.5
MT-CO1 7459.5
LDHB 7435.0
IDH2 7427.5
LDHC 7413.5
TACO1 7403.5
NDUFA13 7316.5
TRAP1 7311.5
ETFDH 7282.5
PDK2 7219.5
TIMMDC1 7186.5
IDH3A 7182.5
NDUFAF3 7105.5
SCO1 6994.5
NDUFS2 6971.5
MT-CO2 6945.5
NDUFV1 6920.5
SDHB 6907.5
DLAT 6848.5
HAGH 6790.5
NDUFAF4 6785.5
IDH3B 6732.5
PDHA1 6639.5
FH 6469.5
ADHFE1 6444.5
NDUFB10 6419.5
COX7A2L 6410.5
UQCRC1 6324.5
NDUFS3 6318.5
UQCRFS1 6235.5
ETFB 6145.5
NDUFV2 6127.5
PDPR 6116.5
NDUFA10 6103.5
DMAC2L 5929.5
COX5B 5910.5
CS 5894.5
NDUFA6 5887.5
MPC1 5835.5
NDUFA2 5728.5
ETFA 5655.5
NDUFB9 5536.5
NDUFS8 5518.5
CYC1 5440.5
SURF1 5398.5
NDUFA11 5077.0
ATP5F1B 5063.5
UQCRH 4971.0
MPC2 4845.5
COX18 4765.5
UQCRQ 4627.5
NDUFB8 4615.0
SDHC 4606.5
NDUFB2 4587.5
OGDH 4470.5
L2HGDH 4434.5
NDUFAB1 4350.5
VDAC1 4260.5
SDHA 4232.0
PDK1 4175.5
UCP2 4090.5
NDUFA7 3973.0
COX4I1 3926.5
UQCR10 3843.5
SLC25A27 3731.5
NDUFA9 3708.5
COX14 3517.5
NDUFA5 3514.5
UQCRC2 3503.5
ATP5PD 3402.5
NDUFB6 3329.5
SUCLG1 3325.5
SUCLA2 3268.5
NDUFC1 3113.5
NDUFS1 3068.5
DLD 2984.5
NDUFAF1 2966.5
ATP5PO 2930.0
COQ10B 2915.5
NDUFAF7 2842.5
COX7B 2750.5
UQCR11 2718.0
NDUFC2 2669.0
ATP5MF 2647.5
IDH3G 2586.5
MT-ND1 2529.5
PPARD 2501.5
NDUFB7 2448.5
NDUFS4 2412.5
PDP2 2306.5
NDUFA3 2298.5
SDHD 2278.0
NDUFAF5 2012.5
MT-ND3 1861.5
CYCS 1802.5
MT-CO3 1568.5
LDHA 1562.5
MT-CYB 1377.5
MT-ND5 1325.5
GLO1 1280.5
NDUFA4 1265.5
MT-ATP6 1243.5
MDH2 1129.5
COX6A1 1068.5
NDUFB5 1061.5
NNT 785.5
COX20 681.5
D2HGDH 530.5
COX5A 481.5
RXRA 395.5
MT-ND4 390.5
ATP5MC3 319.5
MT-ND2 306.5
ME2 9.5
ME1 -80.5
SUCLG2 -231.5
UCP1 -358.5
NDUFB11 -363.5
SLC16A1 -369.5
SLC16A3 -371.5
ATP5PF -401.5
PDK4 -495.5
MT-ND6 -790.5
NUBPL -1174.5
COX19 -1192.5
ATP5F1E -1407.5
COQ10A -2127.5
COX7C -2174.5
TMEM126B -2544.5
ATP5MG -2690.0
NDUFAF6 -2759.5
NDUFS6 -2838.5
ATP5ME -3145.5
NDUFB3 -3539.5
NDUFA1 -3668.5
NDUFB4 -3950.5
SLC25A14 -4573.5
MT-ATP8 -4868.5
UCP3 -5025.5
COX8A -5052.5
SLC16A8 -5262.5
COX6B1 -5355.5
ATP5F1A -6042.5
PDK3 -6753.5
NDUFV3 -6831.5
PM20D1 -7706.5
UQCRB -7789.5
GSTZ1 -7866.5
COX16 -7904.5


Macroautophagy

Macroautophagy
664
set Macroautophagy
setSize 108
pANOVA 3.98e-12
s.dist 0.386
p.adjustANOVA 8.22e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSNK2B 8941.5
PARK7 8928.5
PRKAB2 8910.5
TSC2 8824.5
IFT88 8744.5
SQSTM1 8697.5
ARL13B 8606.5
MFN2 8568.5
ATG16L1 8537.5
PINK1 8514.5
MTMR3 8415.5
MTOR 8379.5
TOMM40 8333.5
MAP1LC3B 8304.0
LAMTOR2 8098.5
CHMP7 7921.5
HSPA8 7910.5
ATG4D 7848.5
MFN1 7800.5
ATG10 7735.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSNK2B 8941.5
PARK7 8928.5
PRKAB2 8910.5
TSC2 8824.5
IFT88 8744.5
SQSTM1 8697.5
ARL13B 8606.5
MFN2 8568.5
ATG16L1 8537.5
PINK1 8514.5
MTMR3 8415.5
MTOR 8379.5
TOMM40 8333.5
MAP1LC3B 8304.0
LAMTOR2 8098.5
CHMP7 7921.5
HSPA8 7910.5
ATG4D 7848.5
MFN1 7800.5
ATG10 7735.5
PLIN3 7535.5
NBR1 7530.5
ATG4B 7497.5
UBA52 7357.5
USP30 7330.5
PIK3C3 7250.5
DYNC1LI1 7142.5
DYNC1H1 6922.5
WIPI1 6633.5
WIPI2 6622.5
WDR45 6616.5
ATG101 6600.5
VCP 6599.5
PLIN2 6558.5
MTMR14 6538.5
TOMM6 6247.5
PRKAA2 6239.5
DYNLL2 6153.5
CHMP3 6105.0
CHMP4C 6023.5
LAMTOR4 5855.5
LAMTOR1 5813.5
PRKAB1 5775.5
GABARAPL1 5606.5
CHMP2B 5497.5
RPTOR 5295.5
ATG5 5242.5
MAP1LC3A 5210.5
DYNC1I2 5195.5
ATG12 5189.5
CHMP4B 5087.5
CSNK2A1 5083.0
CHMP6 4654.5
RHEB 4650.5
ATG9A 4630.5
ATG4C 4511.5
HDAC6 4383.5
RRAGC 4344.5
VDAC1 4260.5
UBE2N 3887.0
EPAS1 3670.5
LAMTOR3 3663.5
ATG4A 3180.5
TOMM20 3158.5
GABARAP 3124.5
PRKAG3 3034.5
RRAGD 2970.5
TOMM22 2933.5
TOMM70 2806.5
WDR45B 2742.5
DYNC1I1 2733.5
PCNT 2681.5
RPS27A 2261.5
ATG13 2194.5
HSF1 1964.5
PIK3R4 1910.5
FUNDC1 1863.5
TSC1 1679.5
RRAGA 1100.5
DYNLL1 767.5
MLST8 534.5
GABARAPL2 501.5
ULK1 458.5
CFTR 341.5
CHMP2A 160.5
PGAM5 146.5
UBC 100.5
ATG7 -152.5
PEX5 -258.5
PRKAG2 -768.5
RB1CC1 -785.5
ATG14 -1324.5
LAMTOR5 -1790.5
MTERF3 -1961.5
SRC -2361.5
DYNC1LI2 -2368.5
RRAGB -2380.5
CETN1 -2424.5
AMBRA1 -2944.5
ATG9B -3412.5
CSNK2A2 -4612.5
ATM -4881.5
TOMM7 -4954.5
UVRAG -5167.5
SLC38A9 -6332.5
PRKAA1 -7243.5
BECN1 -7524.5
ATG3 -7988.5


Autophagy

Autophagy
103
set Autophagy
setSize 122
pANOVA 1.98e-11
s.dist 0.352
p.adjustANOVA 3.57e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSNK2B 8941.5
PARK7 8928.5
PRKAB2 8910.5
TSC2 8824.5
IFT88 8744.5
SQSTM1 8697.5
ARL13B 8606.5
MFN2 8568.5
ATG16L1 8537.5
PINK1 8514.5
HSP90AB1 8445.5
VPS37C 8441.5
MTMR3 8415.5
MTOR 8379.5
TOMM40 8333.5
MAP1LC3B 8304.0
LAMTOR2 8098.5
CHMP7 7921.5
HSPA8 7910.5
ATG4D 7848.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSNK2B 8941.5
PARK7 8928.5
PRKAB2 8910.5
TSC2 8824.5
IFT88 8744.5
SQSTM1 8697.5
ARL13B 8606.5
MFN2 8568.5
ATG16L1 8537.5
PINK1 8514.5
HSP90AB1 8445.5
VPS37C 8441.5
MTMR3 8415.5
MTOR 8379.5
TOMM40 8333.5
MAP1LC3B 8304.0
LAMTOR2 8098.5
CHMP7 7921.5
HSPA8 7910.5
ATG4D 7848.5
MFN1 7800.5
ATG10 7735.5
PLIN3 7535.5
NBR1 7530.5
ATG4B 7497.5
UBA52 7357.5
USP30 7330.5
PIK3C3 7250.5
DYNC1LI1 7142.5
DYNC1H1 6922.5
WIPI1 6633.5
WIPI2 6622.5
WDR45 6616.5
ATG101 6600.5
VCP 6599.5
PLIN2 6558.5
MTMR14 6538.5
MVB12A 6344.5
TOMM6 6247.5
PRKAA2 6239.5
DYNLL2 6153.5
CHMP3 6105.0
VPS28 6061.5
CHMP4C 6023.5
LAMTOR4 5855.5
LAMTOR1 5813.5
PRKAB1 5775.5
GABARAPL1 5606.5
CHMP2B 5497.5
RPTOR 5295.5
ATG5 5242.5
MAP1LC3A 5210.5
DYNC1I2 5195.5
ATG12 5189.5
CHMP4B 5087.5
CSNK2A1 5083.0
UBAP1 4743.5
CHMP6 4654.5
RHEB 4650.5
ATG9A 4630.5
ATG4C 4511.5
HDAC6 4383.5
RRAGC 4344.5
VDAC1 4260.5
UBE2N 3887.0
EPAS1 3670.5
LAMTOR3 3663.5
ATG4A 3180.5
TOMM20 3158.5
GABARAP 3124.5
PRKAG3 3034.5
RRAGD 2970.5
TOMM22 2933.5
TOMM70 2806.5
WDR45B 2742.5
DYNC1I1 2733.5
PCNT 2681.5
RPS27A 2261.5
ATG13 2194.5
HSF1 1964.5
PIK3R4 1910.5
FUNDC1 1863.5
MVB12B 1759.5
TSC1 1679.5
RNASE1 1484.5
RRAGA 1100.5
DYNLL1 767.5
MLST8 534.5
GABARAPL2 501.5
ULK1 458.5
TSG101 385.5
CFTR 341.5
CHMP2A 160.5
PGAM5 146.5
UBC 100.5
VPS37A -109.5
ATG7 -152.5
PEX5 -258.5
PRKAG2 -768.5
RB1CC1 -785.5
ATG14 -1324.5
LAMTOR5 -1790.5
MTERF3 -1961.5
SRC -2361.5
DYNC1LI2 -2368.5
RRAGB -2380.5
CETN1 -2424.5
AMBRA1 -2944.5
ATG9B -3412.5
EEF1A1 -3659.5
VPS37D -4235.5
LAMP2 -4242.5
CSNK2A2 -4612.5
ATM -4881.5
TOMM7 -4954.5
UVRAG -5167.5
VPS37B -5376.5
SLC38A9 -6332.5
PRKAA1 -7243.5
BECN1 -7524.5
GFAP -7775.5
ATG3 -7988.5


Protein localization

Protein localization
925
set Protein localization
setSize 156
pANOVA 4.45e-11
s.dist 0.306
p.adjustANOVA 7.14e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
PEX16 8967.5
TIMM50 8913.5
ACO2 8817.5
LDHD 8757.5
ECI2 8721.5
LONP2 8717.5
ACOX1 8680.5
AMACR 8598.5
CRAT 8595.5
CMC2 8574.5
HSD17B4 8517.5
PITRM1 8463.5
PEX19 8449.5
PECR 8397.5
BAG6 8345.5
TOMM40 8333.5
FXN 8330.5
GET3 8251.5
PEX10 8221.5
PMPCA 8171.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PEX16 8967.5
TIMM50 8913.5
ACO2 8817.5
LDHD 8757.5
ECI2 8721.5
LONP2 8717.5
ACOX1 8680.5
AMACR 8598.5
CRAT 8595.5
CMC2 8574.5
HSD17B4 8517.5
PITRM1 8463.5
PEX19 8449.5
PECR 8397.5
BAG6 8345.5
TOMM40 8333.5
FXN 8330.5
GET3 8251.5
PEX10 8221.5
PMPCA 8171.5
SEC61G 8169.5
ACOT8 8091.5
MLYCD 8087.5
SGTA 7938.5
APP 7804.5
PAOX 7705.0
SLC25A13 7672.5
SLC25A12 7665.5
GRPEL1 7654.5
CHCHD5 7532.5
UBA52 7357.5
PHYH 7272.5
UBE2D3 7189.5
TIMM44 7140.5
HAO2 7043.5
ABCD1 7028.5
PXMP2 6909.5
PEX26 6833.5
GET1 6611.5
MTX1 6581.5
NUDT19 6554.5
IDH1 6455.5
HAO1 6395.5
DHRS4 6392.0
PEX14 6265.5
GDAP1 6263.5
ABCD3 6258.5
TOMM6 6247.5
TIMM23 6237.5
PMPCB 6193.5
TIMM8A 6184.5
HMOX1 6170.5
SAMM50 6128.5
UBE2J2 6118.5
PEX1 6091.5
TIMM21 6056.5
CHCHD4 6017.5
CS 5894.5
TIMM8B 5797.5
HSPD1 5605.5
TAZ 5561.5
UBL4A 5498.5
CYC1 5440.5
ACOT2 5390.0
ECH1 5378.5
COQ2 5364.5
TIMM10 5314.5
SLC25A4 5264.5
ACOX2 5204.5
HSPA9 5108.5
TIMM10B 5095.0
ABCD2 5081.5
ATP5F1B 5063.5
CHCHD3 5047.5
TYSND1 4821.5
NDUFB8 4615.0
PEX7 4597.5
PXMP4 4371.5
VDAC1 4260.5
EMD 4197.5
TIMM17A 3995.5
EHHADH 3987.5
HMGCL 3899.5
TIMM22 3837.5
OTC 3799.5
CAT 3746.5
BCS1L 3714.5
PEX2 3648.5
SLC25A17 3212.5
UBE2D1 3169.5
TOMM20 3158.5
COA4 3056.5
TOMM22 2933.5
TOMM70 2806.5
ACAA1 2649.5
IDH3G 2586.5
ACOX3 2390.5
PEX6 2355.5
RPS27A 2261.5
PAM16 1923.5
CHCHD7 1405.5
TIMM9 1333.5
GNPAT 1278.5
COA6 1213.5
CMC4 1002.5
MTX2 965.5
PRNP 772.5
CYB5A 701.5
COX17 646.5
UBE2D2 126.5
UBC 100.5
TIMM13 27.5
VAMP2 -124.0
PEX12 -239.5
PEX5 -258.5
IDE -266.5
DNAJC19 -270.5
MPV17 -541.5
CAMLG -1154.5
DAO -1182.5
COX19 -1192.5
ZFAND6 -1338.5
OTOF -1453.5
AGXT -1460.5
SLC27A2 -1841.5
STX5 -1984.5
PEX13 -2723.5
USP9X -2762.5
HACL1 -2803.5
PIPOX -3049.5
SERP1 -3120.5
PEX11B -3698.5
GRPEL2 -4259.5
ALDH3A2 -4314.5
AGPS -4511.5
GFER -4610.5
PEX3 -4652.5
HSCB -4732.5
TOMM7 -4954.5
EPHX2 -5201.5
GSTK1 -5244.5
SEC61B -5336.5
GET4 -5543.5
ACBD5 -5836.5
DDO -6010.5
ATP5F1A -6042.5
CROT -6097.5
ACOT4 -6347.5
VAPA -6554.5
BAAT -6684.5
TIMM17B -6725.5
NUDT7 -6823.5
NOS2 -6925.5
STX1A -7287.5
CHCHD10 -7851.5
CHCHD2 -7918.5


Metabolism of proteins

Metabolism of proteins
688
set Metabolism of proteins
setSize 1810
pANOVA 1.06e-10
s.dist 0.0924
p.adjustANOVA 1.53e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
ANK2 9013.5
MRPS18B 9007.5
GAS6 9006.5
ADAMTSL1 9001.5
MIA2 8992.5
COPE 8984.5
COPG1 8946.5
TTLL9 8942.5
CSNK2B 8941.5
DDIT3 8934.5
PARK7 8928.5
PTCD3 8917.5
DAXX 8914.5
VARS1 8908.5
MFGE8 8899.5
ALG3 8889.5
RPL13A 8886.5
FBXO31 8879.5
VARS2 8870.5
RPA1 8853.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ANK2 9013.5
MRPS18B 9007.5
GAS6 9006.5
ADAMTSL1 9001.5
MIA2 8992.5
COPE 8984.5
COPG1 8946.5
TTLL9 8942.5
CSNK2B 8941.5
DDIT3 8934.5
PARK7 8928.5
PTCD3 8917.5
DAXX 8914.5
VARS1 8908.5
MFGE8 8899.5
ALG3 8889.5
RPL13A 8886.5
FBXO31 8879.5
VARS2 8870.5
RPA1 8853.5
IARS2 8848.5
RAD52 8823.5
GALNT2 8816.5
FBXL19 8799.5
USP2 8778.5
DNAJB9 8768.5
USP20 8761.5
PSMB8 8750.5
CUL4A 8748.5
NARS1 8747.5
MRPL30 8739.0
DCAF11 8735.0
NSMCE1 8727.5
SPTAN1 8726.5
NEU1 8725.5
DCTN1 8719.0
LONP2 8717.5
RANGAP1 8716.5
SPTBN1 8714.5
IARS1 8710.5
PSMD1 8707.5
FARS2 8703.5
CALU 8681.5
EXOC3 8672.5
FOXO4 8664.5
NICN1 8655.5
NARS2 8624.5
GPS1 8619.5
RAD23A 8618.5
GORASP1 8615.5
RPLP2 8590.5
EIF4G1 8580.5
PPP6R1 8570.5
TOP1 8567.5
PFDN6 8550.5
COMMD9 8546.5
SELENOS 8543.5
PRMT3 8532.5
DCAF8 8526.5
GSPT1 8520.5
YIF1A 8509.5
LARS2 8505.5
ZBTB17 8498.5
ATP6V0D1 8493.5
TNIP1 8492.5
RNF5 8489.5
RING1 8483.5
CCT3 8472.5
USP25 8470.5
TBCD 8459.5
RHOT1 8433.5
COMMD4 8430.5
KLHL22 8420.0
DCTN2 8402.5
TTLL7 8389.5
USP4 8388.5
MRPL38 8381.5
MRPL37 8373.5
GFM1 8370.5
GFM2 8363.5
CTBP1 8359.5
ARL2 8351.5
GBF1 8347.5
CDC34 8326.5
SULT1A3 8318.0
FBXW10 8307.0
HDGF 8302.5
WRAP53 8290.5
MRPS34 8288.5
COG4 8282.5
LMNA 8271.5
RUVBL1 8255.5
MAVS 8242.5
RAB30 8230.5
USP15 8228.5
PEX10 8221.5
B4GALT5 8216.5
MRPL10 8203.5
QSOX1 8202.5
FN3K 8187.5
ANK3 8175.5
MAN2A2 8172.5
SEC61G 8169.5
HERPUD1 8157.5
MRPL36 8147.5
NFRKB 8144.5
SPSB3 8137.5
ST3GAL1 8113.5
NOD1 8105.5
NUP50 8100.5
MRPS5 8097.5
TECTA 8092.5
KIF5A 8088.5
EXTL1 8084.5
OTULIN 8083.5
MAT2B 8081.5
HIC1 8078.5
HERC2 8073.5
DCAF5 8013.5
ACTR8 8001.5
TUBA4A 7992.5
IGF2 7988.5
COPS2 7987.5
WFS1 7981.5
RPS9 7978.5
UBE2R2 7975.5
MARS2 7972.5
CNIH3 7953.5
CHM 7950.5
EIF2B5 7944.5
MRPS17 7940.0
COPS7A 7934.5
AARS1 7920.5
PIAS4 7919.5
HSPA8 7910.5
MRPL4 7909.5
MRPL12 7898.5
RNF40 7887.5
FEM1A 7869.5
HGS 7865.5
MRPL28 7858.5
WARS1 7854.5
MLEC 7849.5
NAPA 7830.5
SPSB4 7829.5
STS 7827.5
ART3 7824.5
FKBP8 7818.5
MEPE 7815.5
NFYC 7813.5
LARGE1 7807.5
MRPL45 7805.5
APP 7804.5
GNB3 7796.5
EEF2 7789.5
EPRS1 7782.5
ATF4 7774.5
DDA1 7763.5
TSFM 7754.5
MIA3 7748.5
KIFC3 7743.5
NEDD8 7736.5
ASB9 7731.5
MRPS15 7718.5
SYVN1 7703.5
FBXW8 7695.5
COG1 7689.5
USP48 7686.5
GNAT3 7676.5
MRPL1 7666.5
DCUN1D2 7661.5
EIF4E 7655.5
ANKRD9 7645.5
ATF3 7639.5
TUBA8 7628.5
PSMC1 7622.5
PMM2 7602.5
WAC 7598.5
C4A 7594.0
EIF3K 7589.5
USP19 7579.5
FBXW5 7571.5
DOHH 7552.5
TATDN2 7538.0
MRPS30 7513.5
USP5 7503.5
HARS2 7498.5
ASB10 7484.5
EEF1G 7481.5
RAB4A 7480.5
DPH5 7476.5
PAX6 7474.5
MRPL9 7452.5
MRPL19 7446.5
MRPL44 7423.5
RAB1B 7416.5
TUFM 7412.5
LAMB2 7390.5
PCSK9 7387.5
SKP1 7381.5
UBE2M 7376.5
CAPZB 7374.5
UBA52 7357.5
SPTA1 7356.5
UIMC1 7349.5
TTL 7348.5
PSMA6 7345.5
ASB12 7338.5
INO80E 7337.5
ADAMTS20 7332.5
USP30 7330.5
COPS4 7310.5
MCFD2 7307.5
NPPA 7300.5
OXA1L 7295.5
HSPA5 7276.5
EXTL2 7266.5
NUP58 7254.5
TNIP2 7247.5
AIMP2 7246.5
MRPL14 7233.5
AGBL1 7227.5
REN 7205.5
AAAS 7196.5
CUL2 7195.5
UBE2D3 7189.5
KLHDC3 7188.5
PROZ 7183.5
HYOU1 7179.5
RAB5B 7162.5
RAB22A 7156.5
MRPL42 7151.5
MRPL58 7145.5
DYNC1LI1 7142.5
NFYA 7132.5
MRPS9 7125.5
MRPS21 7123.5
CRHR2 7121.5
ST6GALNAC4 7119.5
ASB1 7112.5
MRPL33 7108.5
DARS2 7106.5
SEC24D 7100.5
MRPL46 7097.5
ANK1 7089.5
MRPS2 7088.5
MRPL15 7081.5
MRPS14 7080.5
NCSTN 7078.5
PTEN 7076.5
CCT6A 7075.5
RAB36 7069.5
SKIV2L 7051.5
LMCD1 7050.5
DHPS 7035.0
EEF1A2 7029.5
PSMD4 7024.5
MRPS23 7023.5
UBE2G2 7017.5
MRPL34 7010.5
USP13 7000.5
VDR 6987.5
TAF10 6985.5
LMAN1 6981.5
TMEM115 6978.5
ST3GAL5 6969.5
GGA3 6955.5
ST6GALNAC6 6936.0
DYNC1H1 6922.5
FPGT 6916.5
PSMB5 6910.5
EEF1D 6906.5
ASNS 6904.5
GAPDHS 6874.5
POFUT2 6868.5
SOCS2 6842.5
ASB6 6841.5
CBX8 6838.5
NEURL2 6829.5
PSMB9 6825.5
UBA1 6820.5
ESR1 6813.5
DAP3 6808.5
RPL28 6806.5
EIF3C 6805.0
ACADVL 6798.5
EARS2 6792.5
TPGS1 6786.5
BMI1 6780.0
THSD7B 6773.5
GPAA1 6770.5
MRPL53 6767.5
CANX 6765.5
TRAPPC5 6759.5
FBXO40 6751.5
ACTR1A 6743.5
NAPB 6739.5
INO80B 6726.0
PPARA 6721.5
MEN1 6707.5
MDM2 6693.5
RNF185 6684.5
METTL21A 6669.5
OTUD3 6668.5
GNG8 6665.5
FUCA1 6664.5
SPP1 6663.5
CBX4 6653.5
WIPI1 6633.5
TRAF2 6628.5
TNFAIP3 6624.5
ST6GALNAC2 6618.5
RPL19 6608.5
MSRB2 6607.5
DNMT3B 6605.5
VCP 6599.5
MRPL39 6593.5
GATA4 6591.5
TRAPPC6A 6582.5
BAP1 6571.5
MRPL17 6570.5
PIGB 6565.5
CSF2RA 6556.5
SLC30A5 6555.5
EIF4A2 6546.5
DHDDS 6534.5
PIGC 6530.5
PSMA8 6529.5
GNG5 6527.5
KEAP1 6518.5
DDB1 6499.5
SFTPB 6488.5
RPL29 6487.5
GCNT7 6473.5
CCT7 6470.5
USP21 6463.5
UBXN1 6458.5
RPS10 6457.0
KARS1 6454.5
MRPL11 6448.5
PSME1 6431.5
FUOM 6424.5
FBXL22 6398.5
MRPL54 6383.5
RPN2 6347.5
POMT1 6342.5
ALG12 6339.5
SAR1B 6335.5
MVD 6331.5
N6AMT1 6322.5
PARP1 6319.5
AMFR 6316.5
RPS11 6306.5
MRPS6 6299.5
MRPL47 6290.5
PENK 6289.5
DCTN5 6287.5
P4HB 6271.5
PEX14 6265.5
EIF2B1 6227.5
BTBD1 6223.5
SFTPD 6222.5
MPI 6217.5
EIF5B 6216.5
RAB4B 6215.0
VDAC2 6210.5
SEC16B 6207.5
RAB3A 6182.5
MRPS18A 6180.5
BGLAP 6176.5
ADORA2A 6160.5
PSMD14 6156.5
DYNLL2 6153.5
ADAMTS7 6147.5
ETFB 6145.5
SRP68 6138.5
INO80C 6134.5
RTN4RL1 6122.5
SMC3 6121.5
UBE2J2 6118.5
TRAPPC4 6114.5
MBD5 6111.5
TRAPPC10 6107.0
NUS1 6096.5
PSMB6 6079.5
STAT3 6074.5
MRPL50 6063.5
MRPS24 6060.5
HSP90B1 6043.5
KAT2B 6027.5
MRPL24 6022.5
USP47 6014.5
FBXO30 6011.5
MBOAT4 5997.5
DMP1 5991.5
PSMB7 5988.5
RAB25 5987.5
DPAGT1 5977.5
OTUB1 5970.5
RPL35 5961.5
ATXN3 5958.0
ATXN3L 5958.0
PSMD7 5955.5
DPH3 5953.5
CTSD 5945.0
ADAMTSL5 5934.5
NFKB2 5930.5
METTL22 5926.5
ELOC 5925.5
FBXO11 5918.5
TGFBR2 5914.5
SRD5A3 5897.5
COPS3 5891.5
SNCA 5890.5
RPL13 5882.5
ARFGEF2 5877.5
RAB21 5868.5
MUL1 5864.5
COPS8 5863.5
MARS1 5857.5
FBXO17 5852.5
RBBP5 5832.5
MYC 5828.5
UBE2S 5823.5
RTF1 5815.5
CUL1 5811.5
LMAN2L 5803.5
MRPL13 5793.5
MRPL3 5792.5
PSMD11 5787.5
IKBKG 5786.5
CREBRF 5771.5
TMEM132A 5761.5
SLC34A2 5755.5
EIF3G 5745.5
PPA1 5736.5
PLA2G7 5717.5
CREB3L2 5716.5
MDGA1 5705.5
MSRB1 5687.5
PSMD8 5682.5
TRAPPC2L 5676.5
APOL1 5666.0
AARS2 5661.5
RAD23B 5659.5
GOLM1 5651.5
ST3GAL3 5647.5
ASB2 5646.5
TTLL8 5644.5
EXTL3 5629.5
LMAN2 5626.5
SOCS3 5624.5
RPSA 5610.5
EIF2B2 5602.5
EIF3L 5597.5
APLP2 5581.5
NUB1 5569.5
MYRIP 5566.5
PSMA4 5533.5
ASB5 5531.5
SEC11C 5517.5
PSMD3 5512.5
RBBP7 5506.5
PCMT1 5488.5
RPS14 5480.5
KLHL21 5463.5
MRPS7 5442.5
TADA3 5438.5
SENP2 5433.5
USP12 5428.5
NR1H3 5426.5
APH1A 5425.5
PSMC2 5421.5
TARS2 5405.5
FBXL15 5402.5
NANS 5353.5
ARF5 5340.5
EIF3J 5336.5
NR3C1 5325.5
MRPL22 5316.5
GADD45GIP1 5315.5
CD59 5311.0
H2AZ1 5299.5
KAT2A 5284.5
RPS7 5274.5
SAFB 5272.5
MITF 5268.5
RAB11B 5266.5
SMAD7 5247.5
COMMD5 5237.5
ARF1 5233.5
USO1 5229.5
PSME4 5222.5
MRPL49 5221.5
PSMB1 5207.5
ADGRF5 5202.5
FBXO21 5197.5
DYNC1I2 5195.5
RPL3L 5191.5
TRAF3 5171.5
B2M 5167.5
COPG2 5161.5
TRAPPC9 5159.5
UBE2G1 5157.5
MRPL55 5154.5
GNAI1 5149.5
COPS5 5147.5
RNF123 5138.5
GLB1 5131.5
ASB8 5124.5
USP14 5122.5
SCMH1 5110.5
MRPS26 5107.5
PSMD10 5093.5
RAB35 5091.5
CSNK2A1 5083.0
B3GNT4 5073.5
MRPS11 5060.5
RAB6A 5054.5
SATB1 5049.5
CREB3L3 5035.5
MDGA2 5030.5
PFDN1 5016.5
DCTN6 5013.5
TBCB 5009.5
SFTPC 5007.5
NAPSA 5002.5
SPTB 5001.5
MRPL2 4996.5
PSMC3 4982.5
PLAUR 4965.5
DPH2 4963.5
RPL18 4957.5
EIF5A 4949.0
RPL10A 4938.5
KTN1 4932.5
PIGK 4930.5
NEU2 4929.5
CD55 4922.5
EXOSC6 4913.5
ADRM1 4905.5
FBXO9 4904.5
COMMD3 4874.5
GALNT18 4871.5
PMM1 4867.5
MRPS12 4860.5
COG7 4858.5
FCGR3B 4854.0
B3GALNT2 4852.5
COG5 4835.5
NR4A2 4829.5
PSMA2 4823.0
TTLL13P 4818.0
OS9 4799.5
GALNTL5 4794.5
TFAP2B 4790.5
PPP2R5B 4784.5
RAB5C 4783.5
WSB2 4768.5
EIF2S2 4761.5
PSMC4 4751.5
ISL1 4716.5
TLN1 4705.5
CUL5 4698.5
EXOC7 4692.5
BET1L 4690.5
PSMD2 4685.5
THRB 4674.5
RPL18A 4656.5
PSMD5 4655.5
OTUD5 4643.5
EXOC4 4639.5
THSD1 4628.5
TBC1D20 4621.5
USP24 4607.5
H2AC1 4603.5
GNGT2 4590.5
MRPL35 4577.5
DOLK 4576.5
ADRA2C 4558.5
MYDGF 4557.5
SEL1L 4548.5
GATA6 4534.5
CCDC59 4523.5
RPL9 4522.5
ADORA2B 4518.5
PHC2 4513.5
B3GNT6 4510.5
GARS1 4498.5
DDOST 4494.5
KIN 4487.5
AOPEP 4478.5
SHISA5 4475.5
NUP62 4455.5
XPC 4452.5
RPS4X 4442.5
SENP5 4439.5
CCT5 4438.5
GATA3 4430.5
PSMD6 4428.5
COG2 4421.5
CALR 4416.5
RARS2 4410.5
SLC35C1 4406.5
MRPL20 4398.5
DNAJC3 4351.5
PSMC5 4349.5
RAB11A 4327.5
APC 4290.5
H2AC21 4285.5
PREB 4275.5
HIPK2 4273.5
CPE 4263.5
PFDN5 4262.5
VDAC1 4260.5
YARS1 4257.5
NEU4 4217.5
TUBB4B 4215.5
USP11 4212.5
TP53BP1 4208.5
RPL15 4191.5
POMC 4179.5
ADAMTS15 4172.5
CTNNB1 4165.5
RBX1 4159.5
CARS1 4157.5
CCT8 4121.5
ETF1 4118.5
GALNT15 4101.5
ENGASE 4091.5
AXIN2 4074.5
FOLR2 4060.5
HARS1 4044.5
PRKCSH 4043.5
PGAP1 4042.5
WDR48 4040.5
CNIH1 4023.5
DDX58 4015.5
MRPL52 4008.5
KLHL3 4002.5
IGFBP6 3999.5
SRPRA 3989.5
SARS2 3976.0
KLHL25 3970.5
PSMA7 3962.5
EIF3B 3961.5
JOSD1 3957.5
ARFGAP2 3941.5
STAMBP 3927.5
ADAMTS10 3907.5
DNMT3A 3900.5
PNPLA2 3894.5
POMGNT2 3893.5
UBE2N 3887.0
USP10 3877.5
ADRA2A 3874.5
TMEM129 3873.5
NPL 3871.5
ENPEP 3862.5
RAB40C 3852.5
SUDS3 3848.5
HRC 3828.5
DNAJB11 3817.0
SLC30A6 3807.5
TARS1 3797.5
HIF3A 3792.5
AGTPBP1 3790.5
GFPT1 3782.5
KBTBD8 3780.5
MARCHF6 3779.5
LRRC49 3760.5
EIF3H 3755.5
DCP2 3743.5
OTUB2 3739.5
TNIP3 3734.5
GANAB 3728.5
PGR 3723.5
IZUMO1R 3694.5
TADA2B 3675.5
EPAS1 3670.5
PIGS 3657.5
MRPL32 3649.5
PEX2 3648.5
USP49 3646.5
MRPS27 3638.5
GMPPB 3635.5
APOA1 3608.5
MUC4 3605.5
WDR5 3598.5
CCNE1 3590.5
SSR4 3584.5
DCTN3 3564.5
DERL1 3559.5
BABAM1 3557.5
WDTC1 3554.5
RABGGTA 3527.5
IKBKE 3512.5
EXOSC5 3498.5
TUBA1B 3495.5
JOSD2 3490.5
CBX2 3478.5
MRPS31 3476.5
INHBE 3474.5
APEH 3470.5
MPDU1 3465.5
GGA2 3462.5
USP16 3451.5
HDAC2 3446.5
FBXO27 3439.5
MRRF 3438.5
CCT4 3429.5
EIF2B4 3425.5
GAN 3422.5
GHRL 3419.5
RPS26 3411.5
GNAO1 3374.5
CALM1 3372.5
OTUD7B 3367.5
EIF4EBP1 3336.5
B3GNT5 3294.5
SPON1 3293.5
NUP153 3291.5
CST3 3278.5
ADAMTSL4 3269.5
DERL2 3262.5
MRPL40 3261.5
FBXL20 3258.5
CCT2 3257.5
TAB1 3233.5
NUP35 3225.5
PSMD12 3211.5
GSK3A 3191.5
EIF5A2 3188.5
UBE2D1 3169.5
STC2 3168.5
RPS6 3167.5
TOMM20 3158.5
TMED10 3153.5
FBXW12 3144.5
RENBP 3132.5
FARSA 3117.5
RGS6 3103.5
RPL23 3101.5
NUP42 3099.5
IL33 3098.5
TPP1 3094.5
NSMCE3 3081.5
RNF146 3078.5
ASB17 3075.5
SLC30A8 3069.5
EIF3A 3054.5
COMMD7 3053.0
CNTN3 3046.5
MGAT2 3043.5
MRPS18C 3041.5
MTRF1L 3028.5
EIF2S3 3002.0
NUDT14 2990.5
MBD1 2985.5
ERAL1 2960.5
EP300 2949.5
PSMB2 2944.5
VDAC3 2927.5
TTLL6 2918.5
ARSA 2907.5
EDEM2 2905.5
CMAS 2889.5
EIF3D 2883.5
FBXO6 2870.5
MTIF2 2857.5
DAG1 2817.5
TOMM70 2806.5
COMMD1 2777.5
LYPD3 2772.5
SPCS1 2770.5
LRRC41 2769.5
RAB40B 2765.5
B3GNTL1 2755.5
ST3GAL6 2752.5
RCE1 2747.5
MRPS10 2736.5
DYNC1I1 2733.5
MRPS22 2728.5
AIMP1 2707.5
DNAJC24 2699.5
GBA 2686.5
B4GALT3 2679.5
SUMF1 2678.5
MRPS33 2646.5
TPR 2614.5
CHCHD1 2605.5
KLHL41 2601.5
SMURF2 2597.5
TSPAN15 2576.5
POLB 2550.5
PSME2 2547.5
TRIM28 2545.5
AP3M1 2544.5
RAB33A 2537.5
GALNT3 2536.5
TTLL12 2488.5
H2BC1 2483.5
RAB9B 2475.5
FOXK1 2423.5
PHC1 2419.5
TRAPPC6B 2394.5
YY1 2391.5
XBP1 2388.5
LGALS1 2386.5
MGAT1 2351.5
TRAPPC1 2349.5
CHRDL1 2342.5
RPL8 2340.5
ARF3 2323.5
ZRANB1 2308.5
CBX5 2304.5
PIGT 2300.5
RPS27A 2261.5
YOD1 2244.5
ABCA3 2242.5
CCDC8 2233.5
TSHB 2225.5
RAB20 2222.5
DCAF4 2206.0
NUCB1 2192.5
PARS2 2174.5
ADAM10 2171.5
BACE1 2157.5
VBP1 2152.5
RAB13 2137.0
MRPL18 2121.5
CXXC1 2096.5
MTIF3 2088.5
SPTBN5 2087.5
FBXO32 2080.5
RAB5A 2068.5
GALNT9 2059.5
RPL24 2057.5
UBE2F 2049.0
RAB10 2046.5
RPS5 2028.5
OBSL1 2025.5
TTLL3 2019.0
RHOA 2014.5
UGGT1 2006.5
RABGGTB 1993.5
NFYB 1992.5
MELTF 1990.5
SRP14 1989.5
CUL9 1983.5
TFPT 1969.5
TTF1 1943.5
COMMD8 1941.5
CTSA 1936.5
CTDSP2 1935.5
COPA 1926.5
SAE1 1914.5
QARS1 1901.5
SMC1A 1891.5
ADAMTS1 1877.5
PSMA1 1867.5
EIF1AX 1826.5
RPL22 1825.5
SSR3 1807.5
SEMG1 1806.0
TECTB 1795.5
SOCS5 1794.5
COPB2 1778.5
MRPS25 1771.5
MAN1A2 1767.5
UCHL5 1761.5
LY6D 1755.5
DPH6 1751.5
GOSR2 1741.0
UBA3 1735.5
SARS1 1720.5
ASB14 1714.5
MRPL21 1681.5
TSPAN5 1675.5
MRPL41 1669.5
SRP9 1648.5
RPN1 1646.5
FBXL12 1644.5
PRSS21 1641.0
CDX2 1614.5
ACTR10 1585.5
SP3 1581.5
PSMB4 1567.5
ING2 1559.5
CEBPG 1551.5
PPP6R3 1521.5
KLHL42 1513.5
RAB12 1511.5
FARSB 1504.5
CREB3 1499.5
PSMC6 1488.5
RARS1 1477.5
SLC17A5 1470.5
TSPAN33 1466.5
ASB13 1465.5
INHBC 1464.5
GCNT1 1450.5
IGFBP2 1448.5
ST3GAL4 1445.5
PSME3 1442.5
ASB18 1438.5
SEMA5A 1419.5
PFDN2 1418.5
ITIH2 1402.5
XRCC4 1393.5
CTSZ 1359.5
RANBP2 1353.5
VGF 1314.5
AMDHD2 1304.0
MRPL16 1300.5
PTP4A2 1297.5
GMPPA 1290.5
ERO1A 1289.5
SATB2 1284.5
FSHB 1274.5
RAB2A 1266.5
MRPL51 1260.5
PCSK1 1258.5
H2BC11 1257.5
USP8 1256.5
MUC1 1254.5
MATN3 1246.5
SPCS2 1231.5
SOCS6 1180.5
CARS2 1179.5
PIGX 1176.5
LEO1 1162.5
RAB14 1158.5
ZDHHC2 1157.5
DCAF13 1143.5
RPS8 1133.5
PPARGC1A 1116.5
ADAMTSL2 1114.5
RRAGA 1100.5
COG3 1093.5
RPS27L 1090.5
TRIM27 1088.5
MCRS1 1074.5
NAPG 1073.5
RNF7 1064.5
GALNT14 1059.5
MRPL48 1028.5
CAPZA2 1017.5
ITM2B 983.5
CES1 953.5
EIF3E 897.5
CGA 845.5
GZMH 845.5
IAPP 845.5
KLK13 845.5
LYPD5 845.5
UMOD 845.5
FBXO4 807.5
HDAC3 774.5
ARRB1 770.5
DYNLL1 767.5
TUBB3 760.0
MAN1C1 758.5
ARFGAP3 737.5
CFP 733.5
FSTL3 715.5
COPS6 698.5
DCUN1D3 688.5
FBXO22 659.5
RAB18 658.5
IGFALS 652.5
F2 644.5
SRP19 616.5
ARSL 606.5
SMC6 600.5
CUL7 597.5
CUL4B 587.5
TTLL4 576.5
CUL3 572.5
SUMO3 571.5
BTBD6 559.5
KIF13A 558.5
LARS1 552.5
DCAF6 546.5
RPS15 545.5
F9 544.5
CALB1 528.5
EXOC1 518.5
APOA5 517.5
UAP1 507.5
WDR20 500.5
ART4 498.5
SENP8 470.5
COMMD2 469.5
ADAMTS16 468.5
CCL2 464.5
CNIH2 455.5
ALG5 453.5
FKBP14 439.5
PIGH 434.5
ADD1 414.5
IGFBP5 409.5
HDAC7 402.5
RXRA 395.5
PSMB3 391.5
BARD1 384.5
RPL37 367.5
KLK2 344.0
KLK3 344.0
CFTR 341.5
GSN 316.5
EXOC5 307.5
RPL37A 302.5
FBXW2 264.5
BIRC2 238.5
CTSC 225.5
ATP6AP2 220.5
MUC5B 199.5
TMED2 181.5
LY6H 172.5
NCOA2 159.5
RPS3A 133.5
UBE2D2 126.5
CETN2 125.5
NRN1 109.5
ADAMTS9 102.5
COPS7B 101.5
UBC 100.5
FOXL2 88.5
GALNT11 81.5
LYPD6B 53.0
ODAM 53.0
RPL21 45.0
PDIA6 16.5
PSMA5 5.5
RPL32 0.5
CNTN5 -13.5
SEC23A -37.5
DCUN1D5 -55.5
NUP54 -72.5
RPS28 -86.5
GNG3 -91.5
SPSB2 -102.5
CTR9 -103.5
VAMP2 -124.0
NUP205 -128.5
ATXN7 -150.5
PIGA -165.5
DPM1 -182.5
CCP110 -194.5
ADAMTSL3 -195.5
PML -220.5
PEX12 -239.5
NCOR2 -240.5
PEX5 -258.5
IDE -266.5
PIGQ -284.5
SEC16A -288.5
NEU3 -291.5
PAPPA2 -293.5
RAB44 -325.5
ASB15 -327.5
TRAF6 -331.5
SPP2 -345.5
SUMO1 -348.5
CEBPB -366.5
APCS -372.5
ST8SIA4 -377.5
COPZ1 -411.5
RNF103 -425.5
PIGM -432.5
TFAP2A -436.5
ADAMTS8 -440.5
NDC1 -444.5
B3GNT3 -475.5
C1GALT1C1 -482.5
SBSPON -483.5
KLHL9 -513.5
FURIN -528.5
GMDS -539.5
AGBL2 -547.5
INHBA -562.5
FEM1C -578.5
GNG4 -595.5
MUC6 -599.5
VNN1 -605.5
PIGG -608.5
RNF139 -616.5
PSMA3 -754.5
FAM20A -774.5
NUP88 -800.5
DCTN4 -814.5
B3GNT8 -834.5
CCDC22 -868.5
LMAN1L -882.5
AGBL5 -897.5
CPM -899.5
KCTD7 -902.5
UBE2I -909.5
TGFBI -935.5
INHBB -949.5
POM121 -968.0
POM121C -968.0
AURKA -982.5
ASXL2 -989.5
NR3C2 -1003.5
SHC1 -1008.5
ALG6 -1014.5
TRIM25 -1015.5
TRIM13 -1027.5
TXN -1082.5
UCN -1083.5
EXOC8 -1084.5
FCSK -1086.5
TUBA3E -1087.5
MMP2 -1091.5
ANO8 -1094.5
FFAR4 -1114.5
GCNT4 -1123.5
ALG10 -1129.0
ALG10B -1129.0
ST8SIA5 -1153.5
DPH7 -1164.5
MRPL43 -1166.5
PROC -1175.5
PSMB10 -1181.5
ACTL6A -1190.5
IGFBP7 -1193.5
USP28 -1197.5
FBXW11 -1203.5
EEF1B2 -1217.5
PIGF -1220.5
ARSG -1228.5
RAB24 -1272.5
YARS2 -1276.5
LTBP1 -1317.5
NAT8 -1347.0
NAT8B -1347.0
ARRB2 -1362.5
FBXL18 -1363.5
SCG2 -1375.5
CISH -1377.5
GNAT1 -1378.5
NUP160 -1394.5
GOLGB1 -1400.5
PIGY -1411.5
SEC13 -1413.5
MRPS16 -1420.5
PSMF1 -1438.5
MBD6 -1439.5
KLF4 -1440.5
BCL10 -1468.5
RCN1 -1485.0
ERO1B -1490.5
TGFB1 -1494.5
PIGU -1506.5
B4GALT2 -1507.5
CAPZA3 -1550.5
GNAZ -1587.5
STAM -1589.5
TBCC -1597.5
DCAF10 -1610.5
CDC25A -1611.5
OTOA -1614.5
NR1H2 -1637.5
RAB3D -1641.5
HDAC4 -1650.5
POMT2 -1668.5
RPL36 -1676.5
AMTN -1679.5
RAD18 -1683.5
ASB7 -1685.5
GNG12 -1688.5
NOP56 -1690.5
RPL31 -1702.5
ZBTB16 -1703.5
NUP210 -1705.5
RIPK2 -1709.5
MRPL27 -1728.5
SCFD1 -1743.5
ALG14 -1762.5
DCAF7 -1767.5
ARSK -1772.5
RAB7A -1781.5
UHRF2 -1794.5
KLHL5 -1802.5
USP44 -1803.5
PDIA3 -1811.5
MRPS28 -1815.5
MSRB3 -1828.5
STAM2 -1842.5
BTRC -1843.5
GNAI2 -1866.5
NUP188 -1868.5
TMED9 -1874.5
SRP54 -1887.5
RNF152 -1891.5
CCT6B -1900.5
CD52 -1904.5
USP33 -1939.5
ACTR5 -1944.5
AR -1955.5
STX5 -1984.5
DARS1 -1997.5
EXOC6 -2014.5
GALNT6 -2027.5
USP22 -2034.5
PLET1 -2044.5
GNGT1 -2049.5
FUT8 -2055.5
RAB3B -2066.5
DPM3 -2068.5
DAD1 -2086.5
GFPT2 -2096.5
ANKRD28 -2102.5
LEP -2110.5
PCGF2 -2133.5
UBE2Q2 -2148.5
GNG11 -2149.5
EIF4A1 -2162.5
MOGS -2164.5
PIGO -2167.5
LMO7 -2173.5
CHGB -2180.5
USP18 -2198.0
EXOSC4 -2203.5
TPST2 -2228.5
SLC34A1 -2251.0
TTR -2281.5
EVA1A -2285.5
ARF4 -2289.5
RAB29 -2295.5
UBE2K -2298.5
TUBB1 -2306.5
GALNT1 -2316.5
TULP4 -2320.5
RAB23 -2336.5
DDX5 -2353.5
EIF2B3 -2357.5
RPL7A -2363.5
DYNC1LI2 -2368.5
BRCC3 -2379.5
PRKDC -2381.5
RGS9 -2392.5
PIAS3 -2404.5
FBXO2 -2409.5
UBE2H -2410.5
SEC61A1 -2411.5
DOLPP1 -2413.5
USP3 -2439.5
THBS1 -2452.5
MDM4 -2459.5
CSF2RB -2462.5
SEC22A -2470.5
AGBL4 -2525.5
SFTPA1 -2527.0
SFTPA2 -2527.0
ASGR1 -2535.5
TNKS2 -2539.5
USP34 -2548.5
NTM -2549.5
FBXL5 -2550.5
F7 -2554.5
MRPS35 -2568.5
ST6GALNAC5 -2592.5
PGM3 -2617.5
MSLN -2626.5
CLTRN -2630.0
GNG10 -2665.5
ATF6 -2670.5
PSENEN -2678.5
TIMP1 -2680.5
HSPG2 -2698.5
ERN1 -2704.5
ACE2 -2706.5
PIGW -2715.5
FEM1B -2716.5
PEX13 -2723.5
EXOSC9 -2726.5
DCUN1D1 -2732.5
DPM2 -2752.5
PSMD9 -2755.0
B4GAT1 -2761.5
USP9X -2762.5
PSMD13 -2775.5
ST3GAL2 -2776.5
TRAPPC3 -2779.5
ACHE -2783.5
RPS23 -2786.5
TPGS2 -2790.5
RAB31 -2791.5
LYPD8 -2797.0
INS -2798.5
STAMBPL1 -2799.5
INO80D -2837.5
TCF7L2 -2848.5
KDELR1 -2857.5
CPB2 -2868.5
BST1 -2872.5
AFP -2884.5
IFIH1 -2885.5
MRPS36 -2886.5
CREBBP -2899.5
RFT1 -2901.0
RAB38 -2906.5
NR5A1 -2913.5
ST8SIA1 -2915.5
UBE2W -2941.0
EIF3F -2965.5
TTLL11 -2971.5
WDR61 -2988.5
KIF5C -2998.5
THY1 -3012.5
SEC11A -3017.5
KIF5B -3021.5
MUC16 -3039.5
INCENP -3046.5
FN3KRP -3059.5
B3GLCT -3087.5
SERP1 -3120.5
RAB27B -3126.5
PPP6C -3128.5
SUZ12 -3134.5
RORA -3141.5
LARGE2 -3146.5
GALNT16 -3148.5
NUP85 -3156.5
UCHL1 -3161.5
XPNPEP2 -3162.5
PCNA -3165.5
RGS7 -3177.5
MUC20 -3184.5
TOPORS -3191.5
ADRB2 -3195.5
WARS2 -3221.5
NRIP1 -3232.5
NUP43 -3243.5
RPL7 -3262.5
PPARG -3265.5
HCFC1 -3268.5
CHST8 -3284.5
PSCA -3285.5
NOD2 -3286.5
GPLD1 -3296.5
FAM20C -3301.5
SPCS3 -3307.5
RPS3 -3309.5
ETFBKMT -3317.5
NCOA1 -3368.5
EDEM3 -3377.5
FBXL7 -3388.5
TTLL10 -3395.5
ALG2 -3421.5
CMA1 -3445.5
TMED3 -3454.5
TAF9B -3457.5
CASP8AP2 -3463.5
PCSK2 -3470.5
FBXW4 -3486.5
GCG -3500.5
COPB1 -3511.5
UBE2B -3529.5
POMK -3530.5
SMAD3 -3534.5
OTUD7A -3546.5
DCSTAMP -3549.0
CHST10 -3554.5
SP100 -3563.5
RPS2 -3580.5
RAB2B -3586.5
TUBB6 -3594.5
NAE1 -3606.5
PLA2G4B -3614.0
FBXW7 -3647.5
EEF1A1 -3659.5
CDH2 -3669.5
AREG -3687.5
MAP3K7 -3694.5
GPC3 -3706.5
STX17 -3717.5
DCAF17 -3740.5
BCHE -3751.5
TGOLN2 -3765.5
TCP1 -3778.5
ADAMTS3 -3789.5
GALNT12 -3791.5
SEC24B -3799.5
VCPIP1 -3803.5
SIAH2 -3808.5
MYSM1 -3819.5
APOA4 -3825.5
GALNT5 -3833.5
RAB19 -3864.5
IL6 -3914.5
RNF128 -3922.5
UBE2Z -3933.5
CREB3L1 -3946.5
NGLY1 -3967.5
MAN1B1 -4029.5
ARFGAP1 -4032.5
PIGV -4034.5
WRN -4072.5
COMMD6 -4074.5
PDCL -4136.5
UCHL3 -4145.5
LYZ -4146.5
EXOSC7 -4155.5
FBXO15 -4156.5
NAGK -4160.5
EIF2S1 -4178.5
CDC73 -4185.5
ASXL1 -4189.5
KCTD6 -4195.5
FBXO7 -4204.5
RPL5 -4208.5
FOXK2 -4210.5
CKAP4 -4212.5
MGAT3 -4218.5
RNF168 -4223.5
SEMA5B -4239.5
ADAMTS13 -4240.5
SKP2 -4252.5
TUBB4A -4256.5
IGFBP4 -4257.5
RNF144A -4282.5
BMP15 -4299.5
LY6G6D -4304.5
RPS15A -4306.5
EIF5 -4315.5
SMAD1 -4336.5
RTN4RL2 -4356.5
INHA -4369.5
NANP -4418.5
NSMCE4A -4422.5
ST6GALNAC1 -4426.5
RPS25 -4440.5
YKT6 -4449.5
NSF -4467.5
ALG8 -4469.5
NUP98 -4473.5
CAND1 -4498.5
PIGL -4510.5
RAB33B -4533.5
SPTBN4 -4538.5
RAB8A -4539.5
GGA1 -4549.5
UBD -4558.5
L3MBTL2 -4584.5
ALG1 -4606.5
CSNK2A2 -4612.5
CDCA8 -4631.5
VHL -4639.5
SEC31A -4647.5
ARCN1 -4656.5
ARSB -4665.5
CHST4 -4701.5
PIAS2 -4718.5
PIGP -4723.5
RPL10L -4738.5
B4GALT1 -4742.5
HDAC1 -4797.5
TRMT112 -4815.5
SPARCL1 -4833.5
EIF3M -4836.5
KLHL20 -4856.5
COPZ2 -4860.5
RPL38 -4919.5
FBXO41 -4920.5
ACE -4922.5
UBA6 -4924.5
NR2C1 -4930.5
RPL35A -4964.5
NUP93 -4965.5
COG6 -4981.5
GPR119 -5023.5
KLHL11 -5032.5
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GNG2 -5056.5
CREB3L4 -5057.5
ELOB -5059.5
F8 -5061.5
PTRH2 -5069.5
CPB1 -5071.5
FGF23 -5072.5
PHC3 -5074.5
RNF20 -5077.5
B3GNT9 -5091.5
NUP107 -5093.5
FBXL8 -5096.0
RAB39A -5101.5
ICMT -5125.5
CPA3 -5129.5
USP7 -5134.5
SMAD4 -5135.5
SSR2 -5139.5
SPRN -5143.5
POMGNT1 -5150.5
RAB1A -5165.5
APOA2 -5197.5
P2RY2 -5215.5
ALPL -5259.5
ALG11 -5260.5
AGBL3 -5288.5
TFG -5293.5
B3GNT7 -5294.5
RAB37 -5302.5
UBA2 -5311.5
GALNTL6 -5323.5
NUP133 -5325.5
NOTUM -5332.5
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RAB7B -5352.5
MUC19 -5359.5
TSPAN14 -5364.5
ARSI -5379.5
CSF1 -5418.5
RAB26 -5424.5
XRN2 -5434.5
UBE2L6 -5445.5
CTSH -5458.5
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UBE2V2 -5483.5
UBE2E1 -5485.5
CHD3 -5496.5
LAMB1 -5500.5
HLA-A -5511.0
HLA-B -5511.0
FBN1 -5514.5
RAB15 -5537.5
SUMO2 -5548.5
ADAMTS18 -5549.5
LRR1 -5573.5
USP42 -5582.5
F10 -5595.5
RAB27A -5601.5
ADAMTS6 -5605.5
MGAT4B -5613.5
EEF2KMT -5623.5
LYPD2 -5649.5
GPIHBP1 -5652.5
RAB17 -5670.5
RAB43 -5678.5
SRPRB -5708.5
SEC61A2 -5711.5
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MTFMT -5744.5
GOSR1 -5774.5
SERPINA10 -5777.5
RPL27 -5778.5
GALNT13 -5791.5
PPA2 -5799.5
CSNK1D -5844.5
EXOSC8 -5869.5
RAE1 -5897.5
TNC -5911.5
GNG13 -5917.5
H2BC3 -5930.5
AGT -5931.5
RIPK1 -5961.5
AMBN -5988.5
TBCA -5992.5
BMP4 -6003.5
LYPD1 -6021.5
RAB9A -6033.5
SIN3A -6055.5
NUP155 -6056.5
SEC23IP -6087.5
PFDN4 -6092.5
TNKS -6095.5
USP37 -6101.5
DTL -6103.5
RECK -6124.5
MGAT5 -6125.5
CCNE2 -6133.5
ADAMTS19 -6164.5
FN1 -6177.5
H2BU1 -6178.5
TMED7 -6180.5
FKBP9 -6182.5
BRCA1 -6186.5
HNRNPK -6187.5
FBXL13 -6212.5
RAB34 -6217.5
ST8SIA6 -6219.5
RELA -6220.5
KLHL2 -6254.5
IGFBP3 -6259.5
EEF1E1 -6270.0
ZNF131 -6276.5
ADAMTS5 -6278.5
SHPRH -6283.5
FGG -6286.5
ADAMTS12 -6289.5
APOE -6290.5
KDM1B -6307.5
GNAT2 -6310.5
TGFBR1 -6311.5
ST8SIA3 -6329.5
CNTN4 -6335.5
UBE2A -6339.5
THSD7A -6351.5
RAB6B -6359.5
STT3A -6362.5
PRND -6374.5
FGA -6382.5
RPS18 -6410.5
MGAT4C -6415.5
B4GALT4 -6422.5
THBS2 -6443.5
SPACA4 -6448.5
DDX11 -6454.5
F5 -6460.5
RAD21 -6461.5
RPS19 -6473.5
TTLL1 -6483.5
NTNG2 -6485.5
KLHL13 -6491.5
MXRA8 -6502.5
GCNT3 -6517.5
PLG -6522.5
FSTL1 -6540.5
ALB -6541.5
NPM1 -6547.5
VWA1 -6552.5
NR1I2 -6566.5
TRAM1 -6569.5
ENAM -6615.5
RAB3C -6620.5
RAB8B -6622.5
EIF4H -6631.5
GNB5 -6634.5
RPL30 -6652.5
SNCAIP -6658.5
LTF -6660.5
RPS21 -6677.5
RWDD3 -6691.5
RPLP1 -6712.5
B3GNT2 -6719.5
GSPT2 -6727.5
COMMD10 -6733.5
THRA -6740.5
IGFBP1 -6742.5
SDC2 -6795.5
GNB1 -6797.5
FAU -6841.5
HIF1A -6851.5
MGAT4A -6859.5
UBXN7 -6860.5
ADAMTS4 -6871.5
EXOSC3 -6877.5
DDB2 -6883.5
CCNF -6884.5
PUM2 -6908.5
KDELR2 -6922.5
GNG7 -6928.5
RARA -6942.5
RAB42 -6944.5
MAN2A1 -6966.5
H2BC12 -7021.5
BIRC5 -7024.5
EIF2AK3 -7029.5
TUBA1A -7062.5
SEC22C -7089.5
SCG3 -7093.5
NEGR1 -7118.5
CCNA1 -7120.5
CP -7124.5
SPSB1 -7140.5
HLTF -7165.5
GNAI3 -7185.5
AURKB -7193.5
RPS17 -7220.5
ADAMTS17 -7223.5
SLC30A7 -7224.5
NR1H4 -7229.5
INO80 -7269.5
MANEA -7273.5
KHSRP -7285.5
STX1A -7287.5
MSRA -7292.5
NOP58 -7294.5
TTLL5 -7327.5
EDEM1 -7348.5
RPL3 -7355.5
ALG9 -7371.0
PIGN -7372.5
MRTFA -7387.5
STAG2 -7408.5
PRSS23 -7410.5
ASB4 -7412.5
SPTBN2 -7414.5
LAMC1 -7420.5
CALCA -7427.5
SIAH1 -7434.5
GNB2 -7445.5
FBXL16 -7460.5
ADAMTS2 -7475.5
RPS16 -7482.5
TGFA -7488.5
WSB1 -7494.5
CCNA2 -7508.5
TBCE -7521.0
BECN1 -7524.5
UBE2C -7543.5
LSAMP -7559.5
UBE2T -7584.5
EXOC2 -7589.5
MBTPS2 -7595.5
DIS3 -7602.5
MME -7616.5
LY6G6C -7624.5
ASB3 -7631.5
ST6GAL1 -7635.5
VNN3 -7642.5
ST6GALNAC3 -7651.5
MAGT1 -7656.5
SRP72 -7684.5
PDIA5 -7694.5
KDELR3 -7698.5
BIRC3 -7702.5
MUC13 -7711.5
SEC22B -7731.5
CD109 -7756.5
B4GALT6 -7779.5
RPL6 -7781.5
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BLM -7824.5
GALNT7 -7835.5
RNF2 -7887.5
H3-3A -7895.5
KBTBD6 -7935.0
KBTBD7 -7935.0
OGT -7946.5
SENP1 -7954.5
GNB4 -7962.5
PIAS1 -7967.5
TDG -7977.5
DNMT1 -7997.5
MBTPS1 -8002.5
NTNG1 -8006.5
GNPNAT1 -8010.5
SPON2 -8013.5
OPCML -8017.5
CAMKMT -8018.5
VCAN -8054.5
RPL23A -8061.5
NLRP3 -8069.5
ACTB -8079.5
SSR1 -8085.5
CYLD -8088.5
FBXO10 -8091.5
DCUN1D4 -8092.5
EXOSC1 -8113.5
ANPEP -8118.5
MUC15 -8136.5
ASB16 -8155.5
CEACAM5 -8171.0
CEACAM7 -8171.0
SEC24A -8183.5
FBXW9 -8190.5
TUSC3 -8204.5
SERPIND1 -8205.5
NUP37 -8222.5
ALPG -8227.5
ALPI -8227.5
ASGR2 -8230.5
GRIA1 -8233.5
EXOSC2 -8248.5
NR5A2 -8252.5
PAF1 -8255.5
NSMCE2 -8258.5
FBXL4 -8265.5
MDC1 -8298.5
GNE -8301.5
TUBB2B -8309.5
C3 -8310.5
STAG1 -8335.5
SLC35A1 -8338.5
DPP4 -8343.5
SPHK1 -8349.5
C1GALT1 -8351.5
CDC20 -8352.5
APOB -8370.5
CLSPN -8372.5
GALNT17 -8392.5
FBXL3 -8399.5
AHSG -8405.5
GGCX -8408.5
MAN1A1 -8412.5
SMAD2 -8431.5
PRL -8438.5
NUP214 -8440.5
H4C1 -8450.0
RPS13 -8475.5
TOP2A -8480.5
TSPYL2 -8481.5
MYO5A -8482.5
PAPPA -8549.5
IGF1 -8567.5
ADAMTS14 -8568.5
ERCC8 -8584.5
CDK1 -8596.5
APH1B -8609.5
SERPINC1 -8610.5
DPH1 -8637.5
TPST1 -8639.5
DDX17 -8649.5
KNG1 -8666.5
PARN -8669.5
AMELX -8682.5


Defective CFTR causes cystic fibrosis

Defective CFTR causes cystic fibrosis
272
set Defective CFTR causes cystic fibrosis
setSize 58
pANOVA 2.33e-09
s.dist 0.453
p.adjustANOVA 3.06e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
RNF5 8489.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
DERL3 7165.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
RNF185 6684.5
VCP 6599.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
RNF5 8489.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
DERL3 7165.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
RNF185 6684.5
VCP 6599.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
OS9 4799.5
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
SEL1L 4548.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
ERLIN1 3915.5
DERL1 3559.5
DERL2 3262.5
PSMD12 3211.5
ERLIN2 3026.5
PSMB2 2944.5
PSME2 2547.5
ERLEC1 2361.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
CFTR 341.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
PSMD9 -2755.0
PSMD13 -2775.5


ABC transporter disorders

ABC transporter disorders
2
set ABC transporter disorders
setSize 74
pANOVA 3.62e-09
s.dist 0.397
p.adjustANOVA 4.36e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
ABCB4 8969.5
ABCB6 8912.5
PSMB8 8750.5
PSMD1 8707.5
RNF5 8489.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
DERL3 7165.5
ABCD1 7028.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
RNF185 6684.5
VCP 6599.5
PSMA8 6529.5
ABCC8 6498.5
PSME1 6431.5
KCNJ11 6359.5
PSMD14 6156.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABCB4 8969.5
ABCB6 8912.5
PSMB8 8750.5
PSMD1 8707.5
RNF5 8489.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
DERL3 7165.5
ABCD1 7028.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
RNF185 6684.5
VCP 6599.5
PSMA8 6529.5
ABCC8 6498.5
PSME1 6431.5
KCNJ11 6359.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
OS9 4799.5
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
SEL1L 4548.5
PSMD6 4428.5
PSMC5 4349.5
ABCC2 4308.5
PSMA7 3962.5
ERLIN1 3915.5
APOA1 3608.5
DERL1 3559.5
DERL2 3262.5
PSMD12 3211.5
ERLIN2 3026.5
PSMB2 2944.5
PSME2 2547.5
ERLEC1 2361.5
RPS27A 2261.5
ABCA3 2242.5
ABCA12 2188.5
PSMA1 1867.5
ABCG5 1736.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
ABCD4 1103.5
PSMB3 391.5
CFTR 341.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
ABCB11 -1502.5
PSMD9 -2755.0
PSMD13 -2775.5
ABCC9 -3974.5
ABCA1 -5132.5
ABCG8 -5691.5
ABCC6 -7281.5


Metabolism

Metabolism
673
set Metabolism
setSize 1943
pANOVA 4.82e-09
s.dist 0.0812
p.adjustANOVA 5.36e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
RXRB 9009.5
SLC37A2 8998.5
PPIP5K1 8970.5
ABCB4 8969.5
SGMS1 8963.5
PPT2 8959.0
ELOVL1 8947.5
GPX4 8944.5
CSNK2B 8941.5
PFKFB3 8932.5
PRKAB2 8910.5
RPL13A 8886.5
MED16 8883.5
TPMT 8880.5
COQ7 8860.5
DGUOK 8859.5
SLC25A44 8858.5
PLCB4 8855.5
ALAS1 8847.5
PPIP5K2 8843.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RXRB 9009.5
SLC37A2 8998.5
PPIP5K1 8970.5
ABCB4 8969.5
SGMS1 8963.5
PPT2 8959.0
ELOVL1 8947.5
GPX4 8944.5
CSNK2B 8941.5
PFKFB3 8932.5
PRKAB2 8910.5
RPL13A 8886.5
MED16 8883.5
TPMT 8880.5
COQ7 8860.5
DGUOK 8859.5
SLC25A44 8858.5
PLCB4 8855.5
ALAS1 8847.5
PPIP5K2 8843.5
HMOX2 8835.5
ASS1 8829.5
ACO2 8817.5
MED9 8812.5
AKR1B10 8808.5
INPP5K 8806.5
PKM 8792.5
ACSL6 8787.0
HSD17B8 8783.5
SERINC4 8782.5
AK1 8781.5
BBOX1 8764.5
PISD 8759.5
ASAH2 8756.5
PSMB8 8750.5
OPLAH 8736.5
INPP4B 8729.5
NEU1 8725.5
ECI2 8721.5
ESRRA 8712.5
IARS1 8710.5
PSMD1 8707.5
GBA3 8704.5
GSTO1 8682.5
ACOX1 8680.5
NDUFA12 8677.5
UGT2A3 8675.5
MAN2C1 8662.5
CPNE7 8650.5
CKMT1A 8644.0
CES2 8642.5
ATP5F1D 8640.5
PDP1 8638.5
SPR 8636.5
SYNJ2 8630.5
PHKG2 8609.5
NDUFA8 8607.5
HK1 8603.5
HYAL2 8601.5
SLC19A1 8600.5
AMACR 8598.5
CRAT 8595.5
PARP4 8593.5
RPLP2 8590.5
GLDC 8582.5
PDHX 8564.5
PLAAT3 8555.5
B4GALT7 8547.5
INPPL1 8545.5
HIBCH 8541.5
MOCS2 8539.5
ATP5PB 8530.5
HSD17B4 8517.5
SCAP 8507.5
MED20 8506.5
ALDOA 8495.5
DCXR 8491.5
PLA2G6 8484.5
MED29 8477.5
ADK 8474.5
PHKA1 8469.5
DGAT2 8466.5
GMPR 8456.5
GAMT 8452.5
CHST15 8448.5
HSP90AB1 8445.5
SAMHD1 8440.5
PFKFB2 8437.5
SELENOI 8432.5
NDUFS5 8426.5
BCKDK 8425.5
MTMR3 8415.5
ACP5 8411.5
CIAO1 8408.5
BPGM 8406.5
PECR 8397.5
ACAA2 8392.5
ACSL1 8383.5
GMPS 8360.5
ALAD 8349.5
FXN 8330.5
HS6ST1 8328.5
SULT1A3 8318.0
SULT1A4 8318.0
STARD10 8309.5
NHLRC1 8293.5
ORMDL3 8292.5
SLC25A20 8291.5
PRKAR2A 8262.5
POR 8261.5
BPNT1 8259.5
MAT2A 8239.5
PDHB 8238.5
NT5C3A 8235.5
PCCA 8219.5
B4GALT5 8216.5
MCCC2 8214.5
HMBS 8204.5
ACOXL 8189.5
BSG 8186.5
NFS1 8160.5
ECSIT 8154.5
KYAT1 8136.0
FLAD1 8131.5
CSNK1G2 8129.5
SLC5A5 8126.5
PPP1CA 8118.5
ST3GAL1 8113.5
GPAM 8112.5
DLST 8106.5
PTGR2 8102.0
NUP50 8100.5
COX11 8096.5
ACOT8 8091.5
MLYCD 8087.5
MAT2B 8081.5
LIPH 8080.5
NMRK2 8079.5
ABO 8068.5
ACAD9 8063.5
MTMR7 8052.5
PIP5K1B 8043.5
DGAT1 8042.5
AKR7L 8041.5
PTGES2 8034.5
NRF1 8006.5
ME3 8005.5
GYG1 8004.5
FAHD1 7997.5
ACADS 7996.5
ENPP6 7991.5
RPS9 7978.5
GPD1 7968.5
ENTPD5 7967.5
PDSS2 7955.5
CYP4F8 7954.5
PGK1 7945.5
PIAS4 7919.5
PAPSS2 7904.5
PLCD1 7891.5
DBI 7888.5
HYAL1 7885.5
COQ5 7884.5
UCKL1 7880.5
NDUFS7 7874.5
LPIN1 7864.5
PCYT2 7859.5
NUDT9 7844.5
STS 7827.5
NFYC 7813.5
MED31 7809.5
GSS 7797.5
GNB3 7796.5
COQ9 7787.5
EPRS1 7782.5
OSBPL1A 7776.5
HS3ST6 7772.5
PGLS 7765.5
PLB1 7757.5
RUFY1 7756.5
COX10 7751.5
HK3 7740.5
IMPA2 7734.5
HS3ST1 7726.5
B4GALNT1 7717.5
PPCDC 7714.5
PAOX 7705.0
MPST 7683.5
GCSH 7674.5
SLC25A13 7672.5
ABHD10 7670.5
SLC25A12 7665.5
PPARGC1B 7660.5
ECI1 7640.5
PITPNB 7638.5
CYP7A1 7634.5
PSMC1 7622.5
RIMKLA 7610.5
CIAPIN1 7608.5
CYP27A1 7595.5
NAMPT 7590.5
SMARCD3 7588.5
PIP4K2C 7587.5
TXNRD1 7572.5
CDA 7570.5
GAPDH 7566.5
GBE1 7557.5
SLC27A1 7555.5
PGP 7540.5
PLIN3 7535.5
STK11 7504.5
CPT1B 7496.5
RAB4A 7480.5
MOCS1 7475.5
GYS1 7463.5
MT-CO1 7459.5
PFKM 7448.5
OAT 7447.5
ACP6 7444.5
ACBD6 7437.5
MMAB 7436.5
LDHB 7435.0
CARNS1 7433.5
IDH2 7427.5
LDHC 7413.5
MECR 7404.5
TACO1 7403.5
NOSIP 7380.5
AIP 7363.5
UBA52 7357.5
PSMA6 7345.5
PLA2G4F 7341.5
ASPA 7336.5
NUDT3 7335.5
NT5M 7333.5
MID1IP1 7325.5
NDUFA13 7316.5
GUK1 7313.5
TRAP1 7311.5
MED26 7297.0
PLCD3 7285.5
ETFDH 7282.5
PHYH 7272.5
PRKACA 7262.5
GDE1 7261.5
FECH 7256.5
NUP58 7254.5
PGM1 7253.5
PIK3C3 7250.5
AIMP2 7246.5
PHKB 7245.5
DCTD 7241.5
SRM 7229.5
CA14 7226.5
PDK2 7219.5
UROS 7201.5
AAAS 7196.5
TIMMDC1 7186.5
IDH3A 7182.5
INPP5J 7166.5
ECHS1 7149.5
TNFAIP8 7137.5
NFYA 7132.5
PLA2G12A 7130.5
VAPB 7129.5
SIN3B 7124.5
MTRR 7118.5
NDUFAF3 7105.5
SEC24D 7100.5
GPI 7099.5
PTEN 7076.5
SLC37A4 7073.5
MED11 7072.5
SLC25A11 7070.5
STXBP1 7068.5
GPD1L 7049.5
ISCU 7048.5
HAO2 7043.5
INMT 7038.0
ABCD1 7028.5
PSMD4 7024.5
CIAO3 7015.5
MDH1 7013.5
CKMT2 7012.5
SCO1 6994.5
NAPRT 6991.5
VDR 6987.5
MED4 6976.5
NDUFS2 6971.5
AK7 6958.5
NDST2 6950.0
GNA14 6948.5
MT-CO2 6945.5
ST6GALNAC6 6936.0
FMO1 6932.5
GLA 6921.5
NDUFV1 6920.5
RDH11 6913.0
PSMB5 6910.5
PXMP2 6909.5
SDHB 6907.5
ASNS 6904.5
NCAN 6888.5
RRM2B 6885.5
GAPDHS 6874.5
ENO3 6866.5
ODC1 6863.5
DLAT 6848.5
PPP2R1A 6847.5
CYP8B1 6843.5
SMPD1 6835.5
PGAM2 6832.5
PSMB9 6825.5
RPL28 6806.5
CPT2 6802.5
ACADVL 6798.5
GPT 6797.5
HAGH 6790.5
NDUFAF4 6785.5
FMO2 6782.5
GLRX5 6778.5
GNPDA1 6777.5
PYGM 6750.5
MTMR2 6745.5
PARP6 6741.5
AUH 6735.5
IDH3B 6732.5
PPARA 6721.5
ACADM 6715.5
PLCE1 6711.5
KYAT3 6687.5
SLC25A19 6672.5
GNG8 6665.5
DPEP1 6660.5
GLRX 6659.5
SLC35B2 6657.5
GSTM2 6652.5
PNPLA6 6645.5
PDHA1 6639.5
CYP2F1 6637.5
MTMR4 6626.5
GLUL 6620.5
RPL19 6608.5
NAXD 6580.5
FAM120B 6573.5
PLIN2 6558.5
ENTPD6 6557.5
NUDT19 6554.5
SLC19A2 6550.5
MTMR14 6538.5
PSMA8 6529.5
GNG5 6527.5
TSPO 6509.5
ABCC8 6498.5
CIAO2B 6496.5
RPL29 6487.5
OXCT1 6479.5
FH 6469.5
CYB5R3 6464.5
GNAS 6461.5
APIP 6459.5
RPS10 6457.0
IDH1 6455.5
KARS1 6454.5
ADHFE1 6444.5
PSME1 6431.5
RETSAT 6428.5
PYGB 6421.5
NDUFB10 6419.5
COX7A2L 6410.5
LRP12 6409.5
PHOSPHO1 6396.5
HAO1 6395.5
BCKDHA 6385.0
KCNJ11 6359.5
APRT 6350.5
HADHB 6348.5
CYP11A1 6346.5
GCDH 6343.5
SAR1B 6335.5
MIGA2 6333.5
MVD 6331.5
ACSM4 6327.5
UQCRC1 6324.5
N6AMT1 6322.5
NDUFS3 6318.5
SLC44A4 6314.5
GPC1 6312.5
RPS11 6306.5
ITPKA 6298.5
MORC2 6277.5
ADSL 6261.5
MTM1 6242.5
PRKAA2 6239.5
UQCRFS1 6235.5
NUDT13 6228.5
AACS 6219.5
ADIPOR2 6204.5
GAA 6197.5
CPTP 6189.5
DERA 6188.5
HMOX1 6170.5
MCAT 6165.5
PSMD14 6156.5
ETFB 6145.5
FABP3 6143.5
NDUFV2 6127.5
NUDT12 6124.5
PDPR 6116.5
NDUFA10 6103.5
PIP4K2B 6099.5
AKT1 6092.5
GLUD1 6087.0
GLUD2 6087.0
PSMB6 6079.5
FDFT1 6031.5
SLC25A10 6026.0
PPP2R5D 6015.5
TALDO1 6010.5
AMPD2 6008.5
PARP10 6005.5
LIAS 5989.5
PSMB7 5988.5
B3GAT3 5984.5
FIG4 5967.5
ISCA2 5966.5
RPL35 5961.5
HADH 5956.5
PSMD7 5955.5
HSD17B10 5948.5
PTGR1 5937.5
PRKAR1A 5935.5
DMAC2L 5929.5
NUBP1 5920.5
MTMR6 5917.5
CYP2U1 5915.5
COX5B 5910.5
TYMP 5908.5
STAB2 5904.5
SRD5A3 5897.5
CS 5894.5
GBA2 5889.5
NDUFA6 5887.5
MTMR1 5883.5
RPL13 5882.5
SHMT2 5866.5
MARS1 5857.5
AGK 5849.5
PPOX 5848.5
TPTE 5843.0
TPTE2 5843.0
MPC1 5835.5
RAPGEF3 5818.5
PLEKHA2 5809.5
NME2 5802.5
ACOT11 5798.5
PSMD11 5787.5
GOT1 5784.5
ATIC 5763.5
GPHN 5762.5
NQO2 5753.5
BLVRB 5751.5
PPA1 5736.5
PLBD1 5731.5
NDUFA2 5728.5
PFKL 5725.5
PDSS1 5718.5
MED28 5709.5
DNM2 5708.5
CPT1A 5701.5
RPIA 5686.5
PSMD8 5682.5
AMD1 5673.5
ACOT7 5658.5
ITPKC 5656.5
ETFA 5655.5
ST3GAL3 5647.5
DBT 5632.5
ADIPOR1 5618.5
CKM 5616.5
PNPLA3 5611.5
RPSA 5610.5
CARNMT1 5601.5
KDSR 5592.5
UGP2 5586.5
HIBADH 5578.5
GALT 5567.5
TAZ 5561.5
MAPKAPK2 5540.5
NDUFB9 5536.5
PSMA4 5533.5
PLA2G10 5530.5
IL4I1 5522.5
NDUFS8 5518.5
GPC2 5513.5
PSMD3 5512.5
GPS2 5505.5
BDH1 5493.5
AKR1B1 5489.5
SHMT1 5482.5
RPS14 5480.5
NMNAT1 5464.5
SLC25A28 5456.5
ARV1 5453.5
PLA2G5 5452.5
CYC1 5440.5
GSTO2 5439.5
CHAC2 5437.5
NR1H3 5426.5
AK2 5424.5
GCLM 5423.5
PSMC2 5421.5
SURF1 5398.5
ABHD4 5393.5
ACOT1 5390.0
ACOT2 5390.0
MED27 5382.5
ACACB 5379.5
NOS3 5373.5
COQ2 5364.5
BCAT2 5358.5
ACAT1 5356.5
OSBPL2 5333.5
PLA2G15 5305.5
UPP1 5300.5
PSAP 5285.5
CYP46A1 5277.5
HADHA 5276.5
RPS7 5274.5
PFAS 5269.5
HS3ST5 5240.5
ARF1 5233.5
MCEE 5227.5
PRPS1 5226.5
PSME4 5222.5
BCKDHB 5209.5
PSMB1 5207.5
ACOX2 5204.5
ANKRD1 5199.5
IPPK 5193.5
RPL3L 5191.5
OAZ2 5164.5
AMPD3 5160.5
FABP6 5150.5
GNAI1 5149.5
B3GAT2 5146.5
ACBD4 5145.5
GLB1 5131.5
AGPAT2 5121.5
OSBP 5117.5
CTPS1 5112.5
PSMD10 5093.5
CSNK2A1 5083.0
ALOXE3 5079.5
NDUFA11 5077.0
B3GNT4 5073.5
ATP5F1B 5063.5
NQO1 5061.5
HACD1 5037.5
PPM1K 5032.5
PIK3R1 5011.5
PANK4 4995.5
PSMC3 4982.5
MCCC1 4978.5
INPP5A 4977.5
GPCPD1 4975.5
UQCRH 4971.0
RPL18 4957.5
ACBD7 4955.5
RPL10A 4938.5
NEU2 4929.5
LGMN 4928.5
HDC 4926.5
ACSS3 4914.5
SLC25A37 4882.5
ADCY8 4866.5
PLCB1 4864.5
NUDT11 4863.5
MED24 4861.5
PGM2L1 4850.5
PKLR 4848.5
MGST3 4847.5
MPC2 4845.5
CDS1 4824.5
PSMA2 4823.0
SMPD2 4820.5
BMX 4810.5
MRI1 4801.5
ACAN 4789.5
CARM1 4781.5
ALDOC 4780.5
ALDH7A1 4769.5
COX18 4765.5
PLA2G4C 4756.5
PSMC4 4751.5
LPCAT4 4744.5
SPTLC3 4741.5
CYP26B1 4735.5
PTGDS 4723.0
NMRK1 4712.5
NUBP2 4703.5
RNLS 4686.5
PSMD2 4685.5
PC 4683.5
SMPD4 4682.5
PODXL2 4678.5
PLD3 4675.5
RPL18A 4656.5
PSMD5 4655.5
UQCRQ 4627.5
NDUFB8 4615.0
CDIPT 4612.5
CIDEA 4610.5
SDHC 4606.5
GNGT2 4590.5
NDUFB2 4587.5
AKAP5 4574.5
MED19 4573.5
ADPRM 4568.5
ADRA2C 4558.5
ACAD10 4554.5
LHPP 4549.5
RPL9 4522.5
DCTPP1 4516.5
SLC45A2 4514.5
ENTPD3 4490.5
AZIN2 4480.5
HEXB 4476.5
OGDH 4470.5
DSE 4463.0
DDHD1 4461.5
NUP62 4455.5
PYCR1 4446.5
RPS4X 4442.5
MLX 4435.5
L2HGDH 4434.5
PSMD6 4428.5
SCLY 4420.5
SPHK2 4418.5
HK2 4414.5
ACADL 4411.5
MVK 4402.5
NUDT18 4401.5
FABP12 4365.5
UCK1 4364.5
MTHFD1L 4362.5
NDUFAB1 4350.5
PSMC5 4349.5
FDX2 4347.0
AKR1A1 4321.5
BCAN 4318.5
ABCC2 4308.5
GART 4297.5
ACAD11 4281.5
MOGAT2 4276.5
CRYM 4267.5
SULT1A1 4265.5
SULT1A2 4265.5
VDAC1 4260.5
SUOX 4249.5
AK5 4242.5
SDHA 4232.0
SERINC1 4220.5
NEU4 4217.5
PCYT1A 4196.5
RPL15 4191.5
ELOVL3 4185.5
POMC 4179.5
PDK1 4175.5
ACER1 4169.5
LIPT2 4163.5
ASAH1 4150.5
IVD 4144.5
SLC25A15 4142.5
IP6K3 4126.5
SRD5A2 4122.5
B3GALT1 4114.5
CYP1A2 4097.5
PIP5K1C 4096.5
ACOT13 4095.5
UCP2 4090.5
STARD5 4071.5
FOLR2 4060.5
EPM2A 4052.5
NUDT15 4035.5
PNPLA4 4031.5
HSD17B12 4028.5
GDPD5 4021.5
EHHADH 3987.5
PNPO 3977.5
NDUFA7 3973.0
PSMA7 3962.5
HLCS 3952.5
UMPS 3946.5
SLC2A1 3939.5
ENO2 3938.5
GNMT 3935.5
COX4I1 3926.5
ACSF2 3919.5
ACSS1 3902.5
HMGCL 3899.5
PNPLA2 3894.5
CYP4V2 3891.5
UGT8 3888.5
PLCD4 3885.5
ALAS2 3881.5
ADRA2A 3874.5
CMBL 3867.5
CHP1 3866.5
COQ3 3858.5
UQCR10 3843.5
B3GALT4 3841.5
SGPL1 3836.5
GALC 3835.5
MTARC2 3831.5
BPHL 3824.5
MED6 3823.5
GGT6 3811.5
OTC 3799.5
ABCB7 3781.5
SLC25A27 3731.5
SHPK 3721.0
ADCY5 3713.5
NDUFA9 3708.5
SLC2A2 3700.5
KCNG2 3698.5
TECR 3697.5
ALOX15B 3679.5
MMUT 3678.5
CYP26C1 3674.5
HMGCLL1 3627.5
COQ6 3617.5
NR1D1 3615.5
APOA1 3608.5
ITPK1 3577.5
LPL 3569.5
SERPINA6 3567.5
COX14 3517.5
NDUFA5 3514.5
UQCRC2 3503.5
XDH 3492.5
NDST3 3487.5
RAPGEF4 3416.5
RPS26 3411.5
ATP5PD 3402.5
HYAL3 3392.5
DIO2 3389.5
ERCC2 3386.5
TPH1 3380.5
CALM1 3372.5
AMT 3370.0
ISCA1 3368.5
B3GALT5 3354.5
CA1 3352.5
LPCAT1 3334.5
NDUFB6 3329.5
SUCLG1 3325.5
CDS2 3311.5
ALDH3A1 3308.5
THEM5 3298.5
NUP153 3291.5
PLCB3 3290.5
SAMD8 3287.5
CYP1A1 3279.5
SUCLA2 3268.5
ALOX12 3264.5
ENTPD8 3260.5
CYP2D6 3254.0
PPP2R1B 3230.5
NUP35 3225.5
SLC25A17 3212.5
PSMD12 3211.5
CSGALNACT1 3209.5
AGPAT4 3198.5
ABHD5 3179.5
NT5C 3172.5
RPS6 3167.5
FMO3 3133.5
CBR3 3116.0
GK2 3116.0
NDUFC1 3113.5
ESD 3111.5
RPL23 3101.5
NUP42 3099.5
SEPSECS 3071.5
MMAA 3070.5
NDUFS1 3068.5
PCCB 3066.5
GPT2 3055.5
GRHL1 3027.5
MMACHC 3025.5
SMPD3 3010.5
DLD 2984.5
NDUFAF1 2966.5
CD320 2951.5
EP300 2949.5
PSMB2 2944.5
PANK1 2939.5
ATP5PO 2930.0
COQ10B 2915.5
ARSA 2907.5
PTGES 2895.5
NDOR1 2887.5
FABP7 2873.5
DEGS2 2849.5
IMPDH2 2846.5
NDUFAF7 2842.5
KCNB1 2840.5
DHRS7B 2814.5
TMEM86B 2808.5
HMGCS2 2803.5
ADAL 2796.5
PLA2G3 2764.5
NUDT1 2759.5
ST3GAL6 2752.5
SULT2B1 2751.5
COX7B 2750.5
CA6 2723.5
UQCR11 2718.0
OCRL 2708.5
AIMP1 2707.5
MED21 2698.5
MED25 2697.5
GBA 2686.5
B4GALT3 2679.5
SUMF1 2678.5
NDUFC2 2669.0
ACAA1 2649.5
ATP5MF 2647.5
TPR 2614.5
IDH3G 2586.5
SLC25A32 2585.0
DEGS1 2549.5
PSME2 2547.5
MT-ND1 2529.5
PLA2G4E 2517.5
SLC27A5 2502.5
PPARD 2501.5
AZIN1 2497.5
CNDP2 2481.5
HS3ST2 2452.5
ACMSD 2451.5
NDUFB7 2448.5
FTCD 2441.5
PLAAT1 2413.5
NDUFS4 2412.5
SLC37A1 2401.5
ACOX3 2390.5
ACSF3 2370.5
CHKA 2366.5
G6PC3 2353.5
RPL8 2340.5
ARF3 2323.5
PDP2 2306.5
NDUFA3 2298.5
SDHD 2278.0
ELOVL6 2275.5
RPS27A 2261.5
GOT2 2260.5
AGL 2254.5
GNS 2237.5
SARDH 2232.5
TSHB 2225.5
ALDOB 2220.5
PPP1CC 2218.5
PLA1A 2198.5
FBP1 2195.5
MED30 2191.5
FHL2 2190.5
OAZ1 2182.5
FMOD 2173.5
STARD7 2167.5
PI4K2B 2154.5
MTHFD1 2143.5
ETHE1 2138.5
MED7 2133.5
PI4K2A 2128.5
PPP1R3C 2101.5
MIOX 2098.5
CHKB 2095.5
LRP8 2094.5
ACY3 2085.5
SGPP1 2083.5
CHST9 2079.5
RAB5A 2068.5
RPL24 2057.5
ADCY4 2051.5
ACSM3 2050.5
PRKG2 2039.5
RPS5 2028.5
MED13 2016.5
NDUFAF5 2012.5
TECRL 2005.5
BHMT2 2001.5
TKFC 1998.5
ACSS2 1997.5
PRODH 1996.0
NFYB 1992.5
FBP2 1984.5
ALDH6A1 1978.5
FITM2 1951.5
CTSA 1936.5
SLC22A13 1913.5
PIK3R4 1910.5
QARS1 1901.5
SLC19A3 1894.5
PTGS1 1892.5
CBR4 1888.5
THEM4 1879.5
PON1 1875.5
G6PD 1872.5
PSMA1 1867.5
MT-ND3 1861.5
GATM 1845.5
ENTPD2 1838.5
GPC4 1831.5
RPL22 1825.5
PLPP3 1824.0
PGS1 1811.5
ENTPD4 1809.5
CYCS 1802.5
FABP5 1801.5
CYP4F2 1790.5
ISYNA1 1779.5
HSD17B3 1748.5
SLC35B3 1734.5
SARS1 1720.5
DNPH1 1707.5
DGAT2L6 1698.0
ACOT9 1689.5
G0S2 1684.5
KPNB1 1665.5
GCK 1664.5
MTHFD2 1649.5
MT-CO3 1568.5
PSMB4 1567.5
UPP2 1563.5
LDHA 1562.5
CACNB2 1544.5
CDK19 1539.5
PIK3R2 1532.0
SULT4A1 1525.5
PRKACB 1490.5
PSMC6 1488.5
CKB 1483.5
RARS1 1477.5
BTD 1449.5
NT5C2 1446.5
ST3GAL4 1445.5
PSME3 1442.5
HEXA 1424.0
ABHD14B 1422.5
SDC3 1408.5
FITM1 1404.5
MMS19 1397.5
MT-CYB 1377.5
PCK1 1371.5
CA13 1369.5
RBKS 1368.5
PCK2 1364.5
RANBP2 1353.5
HSD17B1 1339.5
MED1 1332.5
MT-ND5 1325.5
PRKAR1B 1313.5
IDO1 1311.5
ENO1 1307.5
GLO1 1280.5
GNPAT 1278.5
PEMT 1267.5
NDUFA4 1265.5
MT-ATP6 1243.5
ENPP1 1224.5
PFKP 1186.5
PHYKPL 1177.5
PI4KB 1165.5
RAB14 1158.5
ASMT 1147.5
LRP10 1135.5
RPS8 1133.5
PAH 1132.5
MDH2 1129.5
CYP26A1 1119.5
PPARGC1A 1116.5
ASRGL1 1107.5
ABCD4 1103.5
RPS27L 1090.5
GCHFR 1089.5
PTPN13 1079.5
HYKK 1069.5
COX6A1 1068.5
NDUFB5 1061.5
BDH2 1057.5
LPGAT1 1010.5
SC5D 1005.5
GLS 992.5
SBF1 979.5
PPM1L 964.5
CES1 953.5
PLD4 942.5
CHPT1 936.5
GGCT 924.0
GCH1 922.5
FUT11 900.5
CGA 845.5
HSD17B2 845.5
PNLIP 845.5
DCN 798.5
LPCAT3 794.5
SLC44A3 789.5
NNT 785.5
HDAC3 774.5
FUT2 749.5
SPNS2 736.5
IP6K2 735.5
XYLT1 732.5
CA7 728.5
PLEKHA4 719.5
ACACA 711.5
CA4 706.5
CYB5A 701.5
CTH 694.5
SLC35D1 685.5
COX20 681.5
ARG2 673.5
CAD 672.5
ITPA 668.5
B3GALT6 632.5
MBOAT7 613.5
GNA11 611.5
HACD4 609.5
ARSL 606.5
HACD2 581.5
MOCS3 577.5
FASN 566.5
ALDH1A1 561.5
LARS1 552.5
RPS15 545.5
HAL 542.5
D2HGDH 530.5
HILPDA 526.5
OLAH 522.5
APOA5 517.5
COX5A 481.5
PRPS2 477.5
NADK2 422.5
RXRA 395.5
PSMB3 391.5
MT-ND4 390.5
PNPLA7 377.5
FOLH1 374.5
RPL37 367.5
PIK3R3 358.0
FDX1 347.5
OAZ3 346.5
NMNAT3 327.5
RBP2 325.5
ATP5MC3 319.5
PRELP 313.5
MT-ND2 306.5
RPL37A 302.5
PNP 301.5
EPHX1 290.5
ADCY6 282.5
FA2H 277.5
ASPG 274.5
TSTD1 249.5
NCOA3 231.5
ADCY1 230.5
LIPE 223.5
APOC2 211.0
GALE 207.5
SLC5A6 204.5
CYB5B 197.5
CERK 183.5
ADCY9 180.5
SGSH 178.5
NCOA2 159.5
MTR 153.5
FPGS 142.5
RPS3A 133.5
CYP2R1 132.5
CBS 128.0
CBSL 128.0
LTC4S 115.5
GPAT3 105.5
ABCC1 103.5
UBC 100.5
AADAC 70.5
CYP2C19 62.0
CYP2C9 62.0
GLYATL3 53.0
RPL21 45.0
GPAT2 29.5
ME2 9.5
PSMA5 5.5
RPL32 0.5
SLC6A7 -1.5
OSBPL5 -2.5
SLC44A2 -5.5
SLC6A11 -14.5
UROC1 -21.5
FUT1 -27.5
SLC22A1 -29.5
SEC23A -37.5
GYS2 -40.5
INPP4A -49.5
NUP54 -72.5
SGPP2 -76.5
SERINC2 -78.5
ME1 -80.5
UBIAD1 -83.5
LPIN2 -85.5
RPS28 -86.5
GNG3 -91.5
MOCOS -97.5
PARP9 -110.5
PRXL2B -119.5
VAMP2 -124.0
NUP205 -128.5
IDUA -148.5
FUT10 -159.5
XYLT2 -164.5
HAAO -207.5
AASDHPPT -218.5
BCO1 -227.5
SUCLG2 -231.5
NCOR2 -240.5
SERINC3 -247.5
PLEKHA3 -248.5
AADAT -279.5
NEU3 -291.5
IPMK -334.5
UCP1 -358.5
SGMS2 -360.5
MED22 -361.5
NDUFB11 -363.5
SLC16A1 -369.5
SLC16A3 -371.5
PNMT -380.5
ALDH2 -391.0
ACAD8 -392.5
ATP5PF -401.5
GLIPR1 -417.5
COASY -424.5
PRKD2 -442.5
NDC1 -444.5
PITPNM1 -459.5
B3GNT3 -475.5
PAICS -480.5
PDK4 -495.5
SLCO2B1 -527.5
ACY1 -532.0
MAOA -533.5
SRD5A1 -565.5
PSTK -576.5
INPP5D -584.5
TH -588.5
GNG4 -595.5
FABP9 -598.5
VNN1 -605.5
CUBN -609.5
SACM1L -613.5
PTGS2 -620.5
LIPI -695.0
RAN -695.0
PSMA3 -754.5
GUSB -761.5
PIK3C2B -762.5
NT5C1A -764.5
OSBPL3 -766.5
PRKAG2 -768.5
KCNS3 -779.5
ESYT2 -783.5
DPEP3 -788.5
MT-ND6 -790.5
ORMDL1 -793.5
NUP88 -800.5
SULT1E1 -803.0
INPP5E -821.5
SLC52A1 -854.0
SLC52A2 -854.0
CHPF -874.5
UBE2I -909.5
AK4 -910.5
CPOX -940.5
AANAT -943.5
HS3ST3A1 -955.5
POM121 -968.0
POM121C -968.0
SLC6A8 -974.0
GPX1 -1059.5
PPP2CA -1075.5
TXN -1082.5
CYP2W1 -1089.5
DPYS -1098.5
TGS1 -1108.5
SMS -1156.5
PLA2G2D -1167.5
NUBPL -1174.5
PSMB10 -1181.5
DAO -1182.5
PPP2CB -1185.5
COX19 -1192.5
BHMT -1201.5
CA2 -1202.5
PLA2R1 -1219.5
GDPD3 -1227.5
ARSG -1228.5
ADPGK -1273.5
AHRR -1304.5
DMGDH -1312.5
SORD -1329.5
PPCS -1330.5
THRSP -1334.5
INPP1 -1341.5
TDO2 -1342.5
CHST12 -1345.5
SPTLC2 -1355.5
PPAT -1367.5
TPK1 -1370.5
EXT1 -1387.5
SLC3A2 -1390.5
NUP160 -1394.5
ATP5F1E -1407.5
SEC13 -1413.5
PARP8 -1424.5
PSMF1 -1438.5
AGXT -1460.5
AWAT1 -1460.5
G6PC2 -1460.5
SMOX -1471.5
TCN2 -1473.5
CACNA2D2 -1500.5
ABCB11 -1502.5
B4GALT2 -1507.5
CYP24A1 -1550.5
DDAH2 -1601.5
GDA -1609.5
ALOX5AP -1617.5
IP6K1 -1631.5
ACOT6 -1635.5
NR1H2 -1637.5
UCK2 -1642.5
LYVE1 -1649.5
RPL36 -1676.5
GNG12 -1688.5
SNAP25 -1689.5
THRAP3 -1692.5
RPL31 -1702.5
DECR1 -1704.5
NUP210 -1705.5
LTA4H -1739.5
ARSK -1772.5
PPP1CB -1775.5
RGL1 -1778.5
NCOR1 -1780.5
CRYL1 -1787.5
PI4KA -1819.5
TKT -1820.5
PLA2G2A -1826.5
SLC27A2 -1841.5
TYR -1854.5
CHST1 -1862.5
GNAI2 -1866.5
NUP188 -1868.5
ACER2 -1873.5
B3GALNT1 -1890.5
ACADSB -1894.5
PDXK -1897.5
CD36 -1918.5
MTHFR -1922.5
ALOX15 -1942.5
RBP4 -1959.5
DBH -1964.5
FABP2 -1965.5
ALDH1B1 -1967.5
DARS1 -1997.5
MED23 -2037.5
GNGT1 -2049.5
HPSE2 -2064.5
COMT -2069.5
MTMR9 -2080.5
PITPNM3 -2081.5
NOSTRIN -2083.5
OSBPL7 -2104.5
ACSL5 -2111.5
PHKG1 -2112.5
COQ10A -2127.5
TTPA -2139.5
GNG11 -2149.5
DHFR -2160.0
DHFR2 -2160.0
RIMKLB -2163.5
ENTPD1 -2171.5
COX7C -2174.5
PSAT1 -2184.5
MMADHC -2185.5
CYP27B1 -2187.5
IMPA1 -2191.5
CIDEC -2192.5
AHCY -2211.5
GPX2 -2223.5
TPST2 -2228.5
TTR -2281.5
CACNA1A -2300.5
DIO1 -2326.5
CH25H -2328.5
GGT7 -2343.5
TPH2 -2348.5
PLA2G1B -2349.5
CYGB -2358.5
RPL7A -2363.5
RHCE -2367.0
RHD -2367.0
CSAD -2388.5
PNPLA8 -2389.5
ESYT1 -2394.5
CA12 -2398.5
DPEP2 -2406.5
GCLC -2430.5
PLD2 -2440.5
ELOVL4 -2448.5
PIP4K2A -2457.5
NUDT4 -2477.0
INSIG2 -2486.5
KERA -2513.5
POLD1 -2524.5
VAC14 -2537.5
HPD -2540.5
TMEM126B -2544.5
PLCZ1 -2556.5
CHST2 -2558.5
CHST7 -2569.5
TNFRSF21 -2575.5
MBOAT2 -2579.5
PTDSS1 -2612.5
RFK -2632.5
PARP14 -2642.5
RAP1A -2646.5
GNG10 -2665.5
MAOB -2668.5
CERT1 -2672.5
SLC23A2 -2686.5
CYP4B1 -2687.5
ATP5MG -2690.0
GNPDA2 -2695.5
HSPG2 -2698.5
SLC26A2 -2702.5
PLA2G4A -2714.5
PPT1 -2725.5
WASL -2730.5
BPNT2 -2733.5
HPRT1 -2737.5
PSMD9 -2755.0
NDUFAF6 -2759.5
B4GAT1 -2761.5
PSMD13 -2775.5
ST3GAL2 -2776.5
ACHE -2783.5
RPS23 -2786.5
INS -2798.5
HACL1 -2803.5
HGD -2821.5
GLTP -2828.5
NDUFS6 -2838.5
PLPP2 -2849.5
UROD -2854.5
BST1 -2872.5
ORMDL2 -2877.5
ENPP3 -2880.5
ACSBG1 -2898.5
CREBBP -2899.5
HS2ST1 -2912.0
PON3 -2920.5
HPGD -2939.5
SLC9A1 -2945.5
NCOA6 -2951.5
NDST4 -2957.5
CYP39A1 -2975.5
TPO -2993.5
MED18 -3007.5
PIK3R6 -3023.5
BGN -3040.5
NME3 -3042.5
PIPOX -3049.5
CA5B -3071.5
AMPD1 -3079.5
MED17 -3091.0
PLCG1 -3094.5
RORA -3141.5
ATP5ME -3145.5
NUP85 -3156.5
SLC7A5 -3157.5
CHSY1 -3167.5
ALDH18A1 -3171.5
PLD6 -3181.5
AMDHD1 -3197.5
DHCR24 -3198.5
HELZ2 -3208.5
LUM -3215.5
NUP43 -3243.5
RPL7 -3262.5
CRLS1 -3263.5
GPC6 -3264.5
PPARG -3265.5
PRSS1 -3277.5
PRSS3 -3277.5
DDC -3288.5
RPS3 -3309.5
HSD17B7 -3326.5
DDAH1 -3329.5
TIAM2 -3332.5
HAS1 -3350.5
QDPR -3354.5
PIP5K1A -3355.5
AHCYL1 -3359.5
NCOA1 -3368.5
ACOT12 -3398.5
CA9 -3419.5
TYMS -3433.5
SLC46A1 -3448.5
CHAC1 -3483.5
GCG -3500.5
SLC25A21 -3501.5
CERS1 -3507.5
LRP1 -3516.5
DUOX1 -3517.5
TST -3528.5
MIGA1 -3532.5
NDUFB3 -3539.5
HAS2 -3559.5
SDC4 -3567.5
NAXE -3573.5
RBP1 -3579.5
RPS2 -3580.5
ITPKB -3591.5
FAAH -3599.5
ETNK1 -3611.5
PLA2G4B -3614.0
TBXAS1 -3636.5
CHPF2 -3638.5
CBLIF -3640.5
OMD -3645.5
AGPAT3 -3651.5
MAN2B2 -3658.5
GCAT -3664.5
ADCY7 -3667.5
NDUFA1 -3668.5
PHKA2 -3683.5
GPC3 -3706.5
AFMID -3713.5
BCHE -3751.5
ELOVL7 -3762.5
MTHFD2L -3771.5
SLC25A1 -3780.5
PIK3CA -3786.5
GSTM3 -3787.5
GM2A -3790.5
AK6 -3796.5
SEC24B -3799.5
RIDA -3802.5
APOA4 -3825.5
ASL -3827.0
SLC5A8 -3828.5
HSD17B11 -3840.5
NAGLU -3869.5
EXT2 -3876.5
PANK2 -3877.5
CPNE1 -3891.5
ARNT2 -3895.5
XYLB -3905.5
CPNE6 -3918.5
NDUFB4 -3950.5
SLC25A2 -3958.5
PTS -3961.5
DHCR7 -4004.5
UGCG -4014.5
PYCR2 -4028.0
CTRB1 -4046.0
CTRB2 -4046.0
CYP1B1 -4084.5
OCA2 -4102.5
ENOPH1 -4106.5
PRPS1L1 -4113.5
PTDSS2 -4128.5
MTHFS -4150.0
STAR -4173.5
PIK3CD -4177.5
PCBD1 -4187.5
ACER3 -4196.5
RPL5 -4208.5
HS6ST2 -4211.5
PLCH2 -4255.5
TNFAIP8L1 -4263.5
UST -4264.5
SCD -4268.5
PIK3CB -4270.5
PMVK -4277.5
PRKD1 -4279.5
FUT7 -4294.5
RPS15A -4306.5
ALDH3A2 -4314.5
PLEKHA8 -4323.5
CHRM3 -4341.5
NDST1 -4351.5
AS3MT -4357.5
DHODH -4364.5
ALDH1L1 -4367.5
B3GALT2 -4377.5
DUOX2 -4399.5
AOC3 -4419.5
LYPLA1 -4435.5
RPS25 -4440.5
NUP98 -4473.5
PIK3CG -4490.5
AGPS -4511.5
MED10 -4534.5
SLC26A1 -4536.5
CYP19A1 -4541.5
HPGDS -4553.5
CPNE3 -4561.5
AGMAT -4568.5
SLC25A14 -4573.5
ARG1 -4574.5
PIKFYVE -4587.5
ITPR2 -4590.5
DCK -4603.5
CSNK2A2 -4612.5
CSGALNACT2 -4620.5
AGRN -4633.5
LPIN3 -4637.5
PLPP6 -4658.5
ARSB -4665.5
FAR1 -4667.5
NADK -4668.5
SYNJ1 -4672.5
AKR7A3 -4673.5
ACSBG2 -4675.5
CEPT1 -4693.5
ITPR3 -4707.5
HSCB -4732.5
RPL10L -4738.5
ALOX5 -4740.5
B4GALT1 -4742.5
INPP5B -4755.5
PLAAT5 -4768.5
CYP2C18 -4771.0
GPAT4 -4776.5
ELOVL5 -4787.5
TRMT112 -4815.5
PTPMT1 -4823.5
PLA2G4D -4864.5
MT-ATP8 -4868.5
GPD2 -4892.5
CDO1 -4894.5
ADA -4899.5
OSBPL6 -4900.5
NAT1 -4902.0
NAT2 -4902.0
HSD3B7 -4908.5
GSTP1 -4914.5
RPL38 -4919.5
PRKCA -4927.5
PLCG2 -4936.5
RPL35A -4964.5
NUP93 -4965.5
NME1 -4994.5
ARNT -4995.5
PCTP -5012.5
INPP5F -5022.5
UCP3 -5025.5
CA3 -5043.5
COX8A -5052.5
GNG2 -5056.5
ACLY -5064.5
SPTLC1 -5066.5
NUP107 -5093.5
TK1 -5116.5
IDS -5120.0
GLYCTK -5123.5
ABCA1 -5132.5
MBOAT1 -5133.5
LIPT1 -5144.5
TSPOAP1 -5146.5
AK9 -5151.5
FUT9 -5159.5
PTGIS -5179.5
HS3ST3B1 -5185.5
CHSY3 -5190.5
APOA2 -5197.5
MANBA -5199.5
EPHX2 -5201.5
MED15 -5227.5
KYNU -5240.5
GSTK1 -5244.5
SLC16A8 -5262.5
GDPD1 -5272.5
PITPNM2 -5276.5
LPCAT2 -5277.5
GCKR -5290.5
B3GNT7 -5294.5
NUP133 -5325.5
ABHD3 -5337.5
CSPG4 -5340.5
COX6B1 -5355.5
ELOVL2 -5358.5
ARSI -5379.5
SAT1 -5390.5
TBL1XR1 -5408.5
SLC10A2 -5409.5
MGST1 -5414.5
TNFAIP8L2 -5465.5
AMN -5484.5
PGM2 -5494.5
SUMO2 -5548.5
NAGS -5551.5
ITPR1 -5566.5
ACSL3 -5585.5
CYP17A1 -5593.5
SREBF2 -5602.5
SULT1B1 -5607.5
TNFAIP8L3 -5612.5
PIK3R5 -5631.5
IQGAP1 -5645.5
GPIHBP1 -5652.5
OSBPL8 -5658.5
ENTPD7 -5664.5
BLVRA -5672.5
UPB1 -5700.5
GLB1L -5725.5
LMBRD1 -5726.5
STARD3 -5731.5
GNA15 -5733.5
CAV1 -5750.5
SLC22A3 -5757.5
CHST13 -5766.5
RPL27 -5778.5
ESYT3 -5782.5
PHGDH -5798.5
PPA2 -5799.5
OGN -5813.5
CERS2 -5833.5
ACBD5 -5836.5
GMPR2 -5870.5
IMPDH1 -5881.5
EBP -5884.0
HSD11B2 -5896.5
RAE1 -5897.5
GNG13 -5917.5
ADCY2 -5924.5
FUT4 -5927.5
AGT -5931.5
SULT6B1 -5932.5
MTARC1 -5946.0
GLS2 -5976.5
NAT8L -5982.5
SDSL -5984.5
MAN2B1 -6007.0
DDO -6010.5
HMMR -6015.5
ATP5F1A -6042.5
SIN3A -6055.5
NUP155 -6056.5
HPSE -6059.5
LRP2 -6066.5
ANGPTL4 -6076.5
CROT -6097.5
CSPG5 -6102.5
CA5A -6114.5
CHST3 -6115.5
DDHD2 -6123.5
TAT -6128.5
AK8 -6136.5
PIK3C2A -6139.5
PLIN1 -6150.5
CACNB3 -6160.5
PLPP1 -6170.5
CHDH -6185.5
SREBF1 -6213.5
FABP1 -6232.5
CYP4F22 -6238.5
SPTSSA -6249.5
EEF1E1 -6270.0
STARD4 -6281.5
CD38 -6284.5
APOE -6290.5
FADS2 -6303.5
VKORC1L1 -6308.5
MOGAT1 -6309.5
SLC27A3 -6314.5
SLCO1B1 -6316.5
SLCO1B3 -6316.5
VKORC1 -6319.5
B3GAT1 -6322.5
ACOT4 -6347.5
CCNC -6352.5
PON2 -6353.5
SLC23A1 -6369.5
ADI1 -6383.5
PLCB2 -6389.5
AGMO -6395.5
PFKFB1 -6409.5
RPS18 -6410.5
GLCE -6414.5
B4GALT4 -6422.5
PSPH -6432.5
GLP1R -6437.5
HSD17B14 -6440.5
ZDHHC21 -6469.5
HOGA1 -6470.5
RPS19 -6473.5
PAPSS1 -6478.5
OSBPL9 -6482.5
AGPAT5 -6488.5
SLC10A1 -6507.5
PYGL -6536.5
HACD3 -6538.5
ALB -6541.5
GSTM4 -6543.5
VAPA -6554.5
OSBPL10 -6564.5
SLC35D2 -6586.0
CHST14 -6592.5
QPRT -6597.5
GNB5 -6634.5
MTMR12 -6648.5
RPL30 -6652.5
SECISBP2 -6655.5
BRIP1 -6657.5
MED13L -6673.5
RPS21 -6677.5
ADH7 -6680.5
BAAT -6684.5
ALDH3B1 -6699.5
CERS4 -6704.5
HMGCR -6711.5
RPLP1 -6712.5
B3GNT2 -6719.5
SLC36A4 -6726.5
CYP2S1 -6743.5
SERINC5 -6746.5
CMPK1 -6747.5
PDK3 -6753.5
SP1 -6760.5
SYT5 -6783.5
EEFSEC -6785.5
SDC2 -6795.5
GNB1 -6797.5
MTAP -6822.0
NUDT7 -6823.5
NDUFV3 -6831.5
TK2 -6839.5
FAU -6841.5
MAT1A -6853.5
MTMR10 -6886.5
KHK -6910.5
AGXT2 -6924.5
GNG7 -6928.5
CYP4F3 -6929.5
GSR -6931.5
TM7SF2 -6992.5
PEX11A -6997.5
IDI1 -7006.5
IDO2 -7011.5
GLYAT -7026.5
ADCY3 -7027.5
NSDHL -7119.5
CTPS2 -7123.5
CYP51A1 -7126.5
RPE -7132.0
RPEL1 -7132.0
FABP4 -7138.5
MGST2 -7153.5
PFKFB4 -7154.5
NADSYN1 -7182.5
SLC52A3 -7186.5
GC -7191.5
RPS17 -7220.5
TRIB3 -7228.5
NR1H4 -7229.5
STARD3NL -7230.5
SDC1 -7234.5
MGLL -7261.5
HAS3 -7263.5
HMGCS1 -7277.5
STX1A -7287.5
PANK3 -7289.5
MTF1 -7295.5
TXN2 -7297.5
FAR2 -7313.5
ETNPPL -7315.5
RRM2 -7343.5
TBL1X -7352.0
RPL3 -7355.5
CACNA1D -7378.5
AWAT2 -7388.5
GSTA5 -7402.5
PTGES3 -7413.5
PIK3C2G -7419.5
MARCKS -7421.5
GSTM1 -7436.5
LCLAT1 -7440.5
CERS6 -7443.5
GNB2 -7445.5
FAH -7467.5
SLC44A1 -7471.5
DSEL -7476.5
RPS16 -7482.5
AHR -7492.0
FADS1 -7500.5
UGDH -7503.5
ADIPOQ -7514.5
DTYMK -7519.5
SQLE -7540.5
GALK1 -7553.5
CEMIP -7561.5
SRR -7564.5
CHST11 -7582.5
CYP7B1 -7588.5
MBTPS2 -7595.5
CYP3A4 -7611.5
CYP3A43 -7611.5
CYP3A5 -7611.5
CYP3A7 -7611.5
NPAS2 -7617.5
DHTKD1 -7643.5
GK -7655.0
GK3P -7655.0
CYP2E1 -7664.5
TMLHE -7675.5
PM20D1 -7706.5
CTRC -7707.5
NNMT -7709.5
PLEKHA1 -7740.5
NMRAL1 -7748.5
DUT -7757.5
THTPA -7761.5
NT5E -7766.5
BCO2 -7771.5
B4GALT6 -7779.5
RPL6 -7781.5
NUDT5 -7785.5
UQCRB -7789.5
PRODH2 -7791.5
MED12 -7797.5
PARP16 -7800.5
APOC3 -7801.5
ARNTL -7817.5
AGPAT1 -7831.5
CERS3 -7832.5
PLA2G2F -7836.5
AASS -7838.5
LDLR -7842.5
GSTZ1 -7866.5
MFSD2A -7867.5
MINPP1 -7877.5
LSS -7884.5
BCAT1 -7890.5
COX16 -7904.5
AKR1D1 -7916.5
ALDH1L2 -7917.5
SBF2 -7925.5
GNB4 -7962.5
HSD17B13 -7973.5
CD44 -7979.5
CYP2J2 -7983.5
ACSL4 -7994.5
MBTPS1 -8002.5
GGT1 -8036.5
ETNK2 -8040.5
AOC1 -8042.5
IYD -8049.5
VCAN -8054.5
CERS5 -8055.5
NMNAT2 -8056.5
RPL23A -8061.5
SLC6A12 -8096.5
STARD6 -8103.5
PRKD3 -8116.5
LRAT -8126.5
CACNA1C -8127.5
RRM1 -8133.5
PRKAR2B -8138.5
PCYT1B -8157.5
AOX1 -8158.5
SEC24A -8183.5
ACSM1 -8188.5
PLEKHA5 -8201.5
INSIG1 -8208.5
G6PC -8214.5
NUP37 -8222.5
FLVCR1 -8223.5
ALPI -8227.5
PLCH1 -8229.5
ENPP2 -8236.5
SLCO1A2 -8246.5
KMO -8249.5
NAALAD2 -8305.5
CHD9 -8313.5
SDS -8322.5
CPS1 -8324.5
RTEL1 -8330.0
ABCC5 -8348.5
SPHK1 -8349.5
APOB -8370.5
MSMO1 -8374.5
CYP4A11 -8385.0
CYP4A22 -8385.0
CYP4F11 -8385.0
CYP4F12 -8385.0
ADH5 -8387.5
KCNC2 -8389.5
GSTT2 -8398.0
GSTT2B -8398.0
SLC22A2 -8417.5
CYP21A2 -8437.5
NUP214 -8440.5
ACSM5 -8442.5
SLC44A5 -8444.5
ABCC3 -8455.5
DPYD -8466.5
RPS13 -8475.5
ABCG2 -8477.5
SULT1C2 -8488.5
NT5C1B -8494.0
APOM -8495.5
GGT5 -8496.5
GGPS1 -8600.5
PLD1 -8613.5
SULT2A1 -8618.5
ACAT2 -8629.5
CLOCK -8631.5
CYP2A13 -8633.5
CYP2A6 -8633.5
CYP2A7 -8633.5
GRHPR -8636.5
TPST1 -8639.5
TPI1 -8641.5
CACNA1E -8644.5
MED14 -8670.5
PDZD11 -8676.5
UGT1A1 -8678.5


Respiratory electron transport

Respiratory electron transport
1070
set Respiratory electron transport
setSize 96
pANOVA 5.36e-09
s.dist 0.345
p.adjustANOVA 5.53e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDUFA12 8677.5
NDUFA8 8607.5
NDUFS5 8426.5
ECSIT 8154.5
COX11 8096.5
ACAD9 8063.5
NDUFS7 7874.5
MT-CO1 7459.5
TACO1 7403.5
NDUFA13 7316.5
TRAP1 7311.5
ETFDH 7282.5
TIMMDC1 7186.5
NDUFAF3 7105.5
SCO1 6994.5
NDUFS2 6971.5
MT-CO2 6945.5
NDUFV1 6920.5
SDHB 6907.5
NDUFAF4 6785.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFA12 8677.5
NDUFA8 8607.5
NDUFS5 8426.5
ECSIT 8154.5
COX11 8096.5
ACAD9 8063.5
NDUFS7 7874.5
MT-CO1 7459.5
TACO1 7403.5
NDUFA13 7316.5
TRAP1 7311.5
ETFDH 7282.5
TIMMDC1 7186.5
NDUFAF3 7105.5
SCO1 6994.5
NDUFS2 6971.5
MT-CO2 6945.5
NDUFV1 6920.5
SDHB 6907.5
NDUFAF4 6785.5
NDUFB10 6419.5
COX7A2L 6410.5
UQCRC1 6324.5
NDUFS3 6318.5
UQCRFS1 6235.5
ETFB 6145.5
NDUFV2 6127.5
NDUFA10 6103.5
COX5B 5910.5
NDUFA6 5887.5
NDUFA2 5728.5
ETFA 5655.5
NDUFB9 5536.5
NDUFS8 5518.5
CYC1 5440.5
SURF1 5398.5
NDUFA11 5077.0
UQCRH 4971.0
COX18 4765.5
UQCRQ 4627.5
NDUFB8 4615.0
SDHC 4606.5
NDUFB2 4587.5
NDUFAB1 4350.5
SDHA 4232.0
NDUFA7 3973.0
COX4I1 3926.5
UQCR10 3843.5
NDUFA9 3708.5
COX14 3517.5
NDUFA5 3514.5
UQCRC2 3503.5
NDUFB6 3329.5
NDUFC1 3113.5
NDUFS1 3068.5
NDUFAF1 2966.5
COQ10B 2915.5
NDUFAF7 2842.5
COX7B 2750.5
UQCR11 2718.0
NDUFC2 2669.0
MT-ND1 2529.5
NDUFB7 2448.5
NDUFS4 2412.5
NDUFA3 2298.5
SDHD 2278.0
NDUFAF5 2012.5
MT-ND3 1861.5
CYCS 1802.5
MT-CO3 1568.5
MT-CYB 1377.5
MT-ND5 1325.5
NDUFA4 1265.5
COX6A1 1068.5
NDUFB5 1061.5
COX20 681.5
COX5A 481.5
MT-ND4 390.5
MT-ND2 306.5
NDUFB11 -363.5
MT-ND6 -790.5
NUBPL -1174.5
COX19 -1192.5
COQ10A -2127.5
COX7C -2174.5
TMEM126B -2544.5
NDUFAF6 -2759.5
NDUFS6 -2838.5
NDUFB3 -3539.5
NDUFA1 -3668.5
NDUFB4 -3950.5
COX8A -5052.5
COX6B1 -5355.5
NDUFV3 -6831.5
UQCRB -7789.5
COX16 -7904.5


Selective autophagy

Selective autophagy
1127
set Selective autophagy
setSize 56
pANOVA 1.25e-08
s.dist 0.44
p.adjustANOVA 1.2e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSNK2B 8941.5
PARK7 8928.5
PRKAB2 8910.5
IFT88 8744.5
SQSTM1 8697.5
ARL13B 8606.5
MFN2 8568.5
PINK1 8514.5
TOMM40 8333.5
MAP1LC3B 8304.0
HSPA8 7910.5
MFN1 7800.5
PLIN3 7535.5
NBR1 7530.5
UBA52 7357.5
USP30 7330.5
DYNC1LI1 7142.5
DYNC1H1 6922.5
VCP 6599.5
PLIN2 6558.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSNK2B 8941.5
PARK7 8928.5
PRKAB2 8910.5
IFT88 8744.5
SQSTM1 8697.5
ARL13B 8606.5
MFN2 8568.5
PINK1 8514.5
TOMM40 8333.5
MAP1LC3B 8304.0
HSPA8 7910.5
MFN1 7800.5
PLIN3 7535.5
NBR1 7530.5
UBA52 7357.5
USP30 7330.5
DYNC1LI1 7142.5
DYNC1H1 6922.5
VCP 6599.5
PLIN2 6558.5
TOMM6 6247.5
PRKAA2 6239.5
DYNLL2 6153.5
PRKAB1 5775.5
ATG5 5242.5
MAP1LC3A 5210.5
DYNC1I2 5195.5
ATG12 5189.5
CSNK2A1 5083.0
HDAC6 4383.5
VDAC1 4260.5
UBE2N 3887.0
EPAS1 3670.5
TOMM20 3158.5
PRKAG3 3034.5
TOMM22 2933.5
TOMM70 2806.5
DYNC1I1 2733.5
PCNT 2681.5
RPS27A 2261.5
HSF1 1964.5
FUNDC1 1863.5
DYNLL1 767.5
ULK1 458.5
CFTR 341.5
PGAM5 146.5
UBC 100.5
PEX5 -258.5
PRKAG2 -768.5
MTERF3 -1961.5
SRC -2361.5
DYNC1LI2 -2368.5
CETN1 -2424.5
CSNK2A2 -4612.5
ATM -4881.5
TOMM7 -4954.5


ABC-family proteins mediated transport

ABC-family proteins mediated transport
4
set ABC-family proteins mediated transport
setSize 97
pANOVA 1.32e-08
s.dist 0.334
p.adjustANOVA 1.2e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ABCF1 8999.5
ABCB4 8969.5
ABCB6 8912.5
PSMB8 8750.5
PSMD1 8707.5
ABCB8 8594.5
RNF5 8489.5
PEX19 8449.5
PSMC1 7622.5
ABCC4 7377.5
UBA52 7357.5
PSMA6 7345.5
DERL3 7165.5
ABCD1 7028.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
RNF185 6684.5
VCP 6599.5
PSMA8 6529.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABCF1 8999.5
ABCB4 8969.5
ABCB6 8912.5
PSMB8 8750.5
PSMD1 8707.5
ABCB8 8594.5
RNF5 8489.5
PEX19 8449.5
PSMC1 7622.5
ABCC4 7377.5
UBA52 7357.5
PSMA6 7345.5
DERL3 7165.5
ABCD1 7028.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
RNF185 6684.5
VCP 6599.5
PSMA8 6529.5
ABCG4 6520.5
PSME1 6431.5
KCNJ11 6359.5
ABCD3 6258.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
ABCD2 5081.5
PSMC3 4982.5
PSMA2 4823.0
OS9 4799.5
EIF2S2 4761.5
PSMC4 4751.5
ABCC10 4709.5
PSMD2 4685.5
ABCA7 4681.5
PSMD5 4655.5
SEL1L 4548.5
PSMD6 4428.5
PSMC5 4349.5
ABCC2 4308.5
ABCA4 4066.5
PSMA7 3962.5
ERLIN1 3915.5
ABCB7 3781.5
APOA1 3608.5
DERL1 3559.5
DERL2 3262.5
PSMD12 3211.5
ERLIN2 3026.5
EIF2S3 3002.0
PSMB2 2944.5
ABCG1 2687.5
PSME2 2547.5
ERLEC1 2361.5
RPS27A 2261.5
ABCA3 2242.5
ABCA12 2188.5
PSMA1 1867.5
ABCB10 1793.5
ABCG5 1736.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
ABCB9 935.5
PSMB3 391.5
CFTR 341.5
ABCC1 103.5
UBC 100.5
PSMA5 5.5
ABCA2 -465.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
ABCA9 -2610.5
PSMD9 -2755.0
PSMD13 -2775.5
ABCC9 -3974.5
EIF2S1 -4178.5
ABCA6 -4286.5
ABCA5 -4648.5
PEX3 -4652.5
ABCG8 -5691.5
ABCB5 -6245.5
ABCA8 -6809.5
ABCC6 -7281.5
ABCC5 -8348.5
ABCC3 -8455.5


Hh mutants that don't undergo autocatalytic processing are degraded by ERAD

Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
534
set Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
setSize 53
pANOVA 2.63e-08
s.dist 0.442
p.adjustANOVA 2.24e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
SYVN1 7703.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
VCP 6599.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
SYVN1 7703.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
VCP 6599.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
OS9 4799.5
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
SEL1L 4548.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
DERL2 3262.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
ERLEC1 2361.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
SHH -695.0
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
PSMD9 -2755.0
PSMD13 -2775.5


Hh mutants abrogate ligand secretion

Hh mutants abrogate ligand secretion
533
set Hh mutants abrogate ligand secretion
setSize 56
pANOVA 3.1e-08
s.dist 0.428
p.adjustANOVA 2.49e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
SYVN1 7703.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
VCP 6599.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
SYVN1 7703.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
VCP 6599.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
OS9 4799.5
PSMC4 4751.5
PSMD2 4685.5
HHAT 4670.5
PSMD5 4655.5
SEL1L 4548.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
DERL2 3262.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
ERLEC1 2361.5
IHH 2289.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
SHH -695.0
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
DHH -1812.5
PSMD9 -2755.0
PSMD13 -2775.5


Interleukin-1 signaling

Interleukin-1 signaling
587
set Interleukin-1 signaling
setSize 94
pANOVA 4.17e-08
s.dist 0.327
p.adjustANOVA 3.18e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
AGER 8956.5
PSMB8 8750.5
PSMD1 8707.5
SQSTM1 8697.5
NFKBIB 8429.5
NOD1 8105.5
NKIRAS2 7943.5
APP 7804.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
NKIRAS1 7353.5
PSMA6 7345.5
TNIP2 7247.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
TAB2 6793.5
PELI3 6700.5
IL1B 6648.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AGER 8956.5
PSMB8 8750.5
PSMD1 8707.5
SQSTM1 8697.5
NFKBIB 8429.5
NOD1 8105.5
NKIRAS2 7943.5
APP 7804.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
NKIRAS1 7353.5
PSMA6 7345.5
TNIP2 7247.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
TAB2 6793.5
PELI3 6700.5
IL1B 6648.5
PSMA8 6529.5
PSME1 6431.5
MAP3K8 6329.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
NFKB2 5930.5
CUL1 5811.5
PSMD11 5787.5
IKBKG 5786.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
IL1RAP 5449.5
TAB3 5441.5
PSMC2 5421.5
MAP2K1 5275.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
RBX1 4159.5
PSMA7 3962.5
UBE2N 3887.0
MAP2K6 3880.5
TAB1 3233.5
PSMD12 3211.5
PSMB2 2944.5
IRAK2 2926.5
PSME2 2547.5
MAP3K3 2535.5
NFKB1 2395.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
MYD88 1336.5
TOLLIP 1309.5
IKBKB 1146.5
IL1R2 1075.5
IL1RN 670.5
IRAK1 408.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
TRAF6 -331.5
PSMA3 -754.5
PSMB10 -1181.5
FBXW11 -1203.5
MAP2K4 -1376.5
PSMF1 -1438.5
RIPK2 -1709.5
BTRC -1843.5
CHUK -2390.5
HMGB1 -2574.5
PSMD9 -2755.0
PSMD13 -2775.5
NOD2 -3286.5
MAP3K7 -3694.5
PELI2 -4274.5
IRAK3 -5654.5
PELI1 -6202.5
RELA -6220.5
IRAK4 -6357.5
IL1R1 -7048.5
IL1A -7386.5


tRNA Aminoacylation

tRNA Aminoacylation
1440
set tRNA Aminoacylation
setSize 42
pANOVA 5.94e-08
s.dist 0.483
p.adjustANOVA 4.24e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
VARS1 8908.5
VARS2 8870.5
IARS2 8848.5
NARS1 8747.5
IARS1 8710.5
FARS2 8703.5
NARS2 8624.5
LARS2 8505.5
MARS2 7972.5
AARS1 7920.5
WARS1 7854.5
EPRS1 7782.5
HARS2 7498.5
AIMP2 7246.5
DARS2 7106.5
EARS2 6792.5
KARS1 6454.5
MARS1 5857.5
PPA1 5736.5
AARS2 5661.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VARS1 8908.5
VARS2 8870.5
IARS2 8848.5
NARS1 8747.5
IARS1 8710.5
FARS2 8703.5
NARS2 8624.5
LARS2 8505.5
MARS2 7972.5
AARS1 7920.5
WARS1 7854.5
EPRS1 7782.5
HARS2 7498.5
AIMP2 7246.5
DARS2 7106.5
EARS2 6792.5
KARS1 6454.5
MARS1 5857.5
PPA1 5736.5
AARS2 5661.5
TARS2 5405.5
GARS1 4498.5
RARS2 4410.5
YARS1 4257.5
CARS1 4157.5
HARS1 4044.5
SARS2 3976.0
TARS1 3797.5
FARSA 3117.5
AIMP1 2707.5
PARS2 2174.5
QARS1 1901.5
SARS1 1720.5
FARSB 1504.5
RARS1 1477.5
CARS2 1179.5
LARS1 552.5
YARS2 -1276.5
DARS1 -1997.5
WARS2 -3221.5
PPA2 -5799.5
EEF1E1 -6270.0


Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
1071
set Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
setSize 117
pANOVA 6.16e-08
s.dist 0.29
p.adjustANOVA 4.24e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDUFA12 8677.5
ATP5F1D 8640.5
NDUFA8 8607.5
ATP5PB 8530.5
NDUFS5 8426.5
ECSIT 8154.5
COX11 8096.5
ACAD9 8063.5
NDUFS7 7874.5
MT-CO1 7459.5
TACO1 7403.5
NDUFA13 7316.5
TRAP1 7311.5
ETFDH 7282.5
TIMMDC1 7186.5
NDUFAF3 7105.5
SCO1 6994.5
NDUFS2 6971.5
MT-CO2 6945.5
NDUFV1 6920.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFA12 8677.5
ATP5F1D 8640.5
NDUFA8 8607.5
ATP5PB 8530.5
NDUFS5 8426.5
ECSIT 8154.5
COX11 8096.5
ACAD9 8063.5
NDUFS7 7874.5
MT-CO1 7459.5
TACO1 7403.5
NDUFA13 7316.5
TRAP1 7311.5
ETFDH 7282.5
TIMMDC1 7186.5
NDUFAF3 7105.5
SCO1 6994.5
NDUFS2 6971.5
MT-CO2 6945.5
NDUFV1 6920.5
SDHB 6907.5
NDUFAF4 6785.5
NDUFB10 6419.5
COX7A2L 6410.5
UQCRC1 6324.5
NDUFS3 6318.5
UQCRFS1 6235.5
ETFB 6145.5
NDUFV2 6127.5
NDUFA10 6103.5
DMAC2L 5929.5
COX5B 5910.5
NDUFA6 5887.5
NDUFA2 5728.5
ETFA 5655.5
NDUFB9 5536.5
NDUFS8 5518.5
CYC1 5440.5
SURF1 5398.5
NDUFA11 5077.0
ATP5F1B 5063.5
UQCRH 4971.0
COX18 4765.5
UQCRQ 4627.5
NDUFB8 4615.0
SDHC 4606.5
NDUFB2 4587.5
NDUFAB1 4350.5
SDHA 4232.0
UCP2 4090.5
NDUFA7 3973.0
COX4I1 3926.5
UQCR10 3843.5
SLC25A27 3731.5
NDUFA9 3708.5
COX14 3517.5
NDUFA5 3514.5
UQCRC2 3503.5
ATP5PD 3402.5
NDUFB6 3329.5
NDUFC1 3113.5
NDUFS1 3068.5
NDUFAF1 2966.5
ATP5PO 2930.0
COQ10B 2915.5
NDUFAF7 2842.5
COX7B 2750.5
UQCR11 2718.0
NDUFC2 2669.0
ATP5MF 2647.5
MT-ND1 2529.5
NDUFB7 2448.5
NDUFS4 2412.5
NDUFA3 2298.5
SDHD 2278.0
NDUFAF5 2012.5
MT-ND3 1861.5
CYCS 1802.5
MT-CO3 1568.5
MT-CYB 1377.5
MT-ND5 1325.5
NDUFA4 1265.5
MT-ATP6 1243.5
COX6A1 1068.5
NDUFB5 1061.5
COX20 681.5
COX5A 481.5
MT-ND4 390.5
ATP5MC3 319.5
MT-ND2 306.5
UCP1 -358.5
NDUFB11 -363.5
ATP5PF -401.5
MT-ND6 -790.5
NUBPL -1174.5
COX19 -1192.5
ATP5F1E -1407.5
COQ10A -2127.5
COX7C -2174.5
TMEM126B -2544.5
ATP5MG -2690.0
NDUFAF6 -2759.5
NDUFS6 -2838.5
ATP5ME -3145.5
NDUFB3 -3539.5
NDUFA1 -3668.5
NDUFB4 -3950.5
SLC25A14 -4573.5
MT-ATP8 -4868.5
UCP3 -5025.5
COX8A -5052.5
COX6B1 -5355.5
ATP5F1A -6042.5
NDUFV3 -6831.5
PM20D1 -7706.5
UQCRB -7789.5
COX16 -7904.5


AUF1 (hnRNP D0) binds and destabilizes mRNA

AUF1 (hnRNP D0) binds and destabilizes mRNA
21
set AUF1 (hnRNP D0) binds and destabilizes mRNA
setSize 51
pANOVA 8.72e-08
s.dist 0.433
p.adjustANOVA 5.49e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
EIF4G1 8580.5
HSPA8 7910.5
HSPA1A 7838.0
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
EIF4G1 8580.5
HSPA8 7910.5
HSPA1A 7838.0
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
HSPB1 682.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
PSMD9 -2755.0
PSMD13 -2775.5
HNRNPD -8425.5


Regulation of ornithine decarboxylase (ODC)

Regulation of ornithine decarboxylase (ODC)
1054
set Regulation of ornithine decarboxylase (ODC)
setSize 49
pANOVA 8.74e-08
s.dist 0.442
p.adjustANOVA 5.49e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
ODC1 6863.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
ODC1 6863.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
OAZ2 5164.5
PSMD10 5093.5
NQO1 5061.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
AZIN1 2497.5
OAZ1 2182.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
OAZ3 346.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
PSMD9 -2755.0
PSMD13 -2775.5


NIK-->noncanonical NF-kB signaling

NIK-->noncanonical NF-kB signaling
739
set NIK-->noncanonical NF-kB signaling
setSize 56
pANOVA 9.53e-08
s.dist 0.412
p.adjustANOVA 5.74e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBE2M 7376.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
NFKB2 5930.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBE2M 7376.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
NFKB2 5930.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
MAP3K14 2011.5
PSMA1 1867.5
UBA3 1735.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
RELB 1279.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
FBXW11 -1203.5
PSMF1 -1438.5
BTRC -1843.5
CHUK -2390.5
PSMD9 -2755.0
PSMD13 -2775.5


Degradation of GLI2 by the proteasome

Degradation of GLI2 by the proteasome
286
set Degradation of GLI2 by the proteasome
setSize 55
pANOVA 1.1e-07
s.dist 0.414
p.adjustANOVA 6.39e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PRKACA 7262.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PRKACA 7262.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
SUFU 5369.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
RBX1 4159.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PRKACB 1490.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
GSK3B -787.5
PSMB10 -1181.5
PSMF1 -1438.5
BTRC -1843.5
PSMD9 -2755.0
PSMD13 -2775.5
CSNK1A1 -5751.5


Regulation of Apoptosis

Regulation of Apoptosis
1010
set Regulation of Apoptosis
setSize 50
pANOVA 1.34e-07
s.dist 0.431
p.adjustANOVA 7.2e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
OPA1 8625.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
OMA1 5608.5
PSMA4 5533.5
PSMD3 5512.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
OPA1 8625.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
OMA1 5608.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PAK2 449.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
PSMD9 -2755.0
PSMD13 -2775.5
ARHGAP10 -2997.5


Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle
936
set Pyruvate metabolism and Citric Acid (TCA) cycle
setSize 52
pANOVA 1.34e-07
s.dist 0.423
p.adjustANOVA 7.2e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACO2 8817.5
PDP1 8638.5
PDHX 8564.5
PDHB 8238.5
BSG 8186.5
DLST 8106.5
ME3 8005.5
FAHD1 7997.5
LDHB 7435.0
IDH2 7427.5
LDHC 7413.5
PDK2 7219.5
IDH3A 7182.5
SDHB 6907.5
DLAT 6848.5
HAGH 6790.5
IDH3B 6732.5
PDHA1 6639.5
FH 6469.5
ADHFE1 6444.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACO2 8817.5
PDP1 8638.5
PDHX 8564.5
PDHB 8238.5
BSG 8186.5
DLST 8106.5
ME3 8005.5
FAHD1 7997.5
LDHB 7435.0
IDH2 7427.5
LDHC 7413.5
PDK2 7219.5
IDH3A 7182.5
SDHB 6907.5
DLAT 6848.5
HAGH 6790.5
IDH3B 6732.5
PDHA1 6639.5
FH 6469.5
ADHFE1 6444.5
PDPR 6116.5
CS 5894.5
MPC1 5835.5
MPC2 4845.5
SDHC 4606.5
OGDH 4470.5
L2HGDH 4434.5
VDAC1 4260.5
SDHA 4232.0
PDK1 4175.5
SUCLG1 3325.5
SUCLA2 3268.5
DLD 2984.5
IDH3G 2586.5
PPARD 2501.5
PDP2 2306.5
SDHD 2278.0
LDHA 1562.5
GLO1 1280.5
MDH2 1129.5
NNT 785.5
D2HGDH 530.5
RXRA 395.5
ME2 9.5
ME1 -80.5
SUCLG2 -231.5
SLC16A1 -369.5
SLC16A3 -371.5
PDK4 -495.5
SLC16A8 -5262.5
PDK3 -6753.5
GSTZ1 -7866.5


Metabolism of polyamines

Metabolism of polyamines
686
set Metabolism of polyamines
setSize 57
pANOVA 1.49e-07
s.dist 0.402
p.adjustANOVA 7.71e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PAOX 7705.0
PSMC1 7622.5
PSMA6 7345.5
SRM 7229.5
PSMD4 7024.5
PSMB5 6910.5
ODC1 6863.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
AMD1 5673.5
PSMA4 5533.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PAOX 7705.0
PSMC1 7622.5
PSMA6 7345.5
SRM 7229.5
PSMD4 7024.5
PSMB5 6910.5
ODC1 6863.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
AMD1 5673.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
OAZ2 5164.5
PSMD10 5093.5
NQO1 5061.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
AZIN2 4480.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
AZIN1 2497.5
OAZ1 2182.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
OAZ3 346.5
PSMA5 5.5
PSMA3 -754.5
SMS -1156.5
PSMB10 -1181.5
PSMF1 -1438.5
SMOX -1471.5
PSMD9 -2755.0
PSMD13 -2775.5
AGMAT -4568.5
SAT1 -5390.5


Cross-presentation of soluble exogenous antigens (endosomes)

Cross-presentation of soluble exogenous antigens (endosomes)
231
set Cross-presentation of soluble exogenous antigens (endosomes)
setSize 48
pANOVA 1.56e-07
s.dist 0.438
p.adjustANOVA 7.8e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
FCGR1A 7708.0
FCGR1B 7708.0
PSMC1 7622.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
FCGR1A 7708.0
FCGR1B 7708.0
PSMC1 7622.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
CD207 4077.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
PSMA5 5.5
MRC1 -413.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
PSMD9 -2755.0
PSMD13 -2775.5
MRC2 -2840.5


Mitochondrial Fatty Acid Beta-Oxidation

Mitochondrial Fatty Acid Beta-Oxidation
703
set Mitochondrial Fatty Acid Beta-Oxidation
setSize 36
pANOVA 1.69e-07
s.dist 0.504
p.adjustANOVA 8.09e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACAA2 8392.5
PCCA 8219.5
ACADS 7996.5
DBI 7888.5
ECI1 7640.5
ACBD6 7437.5
MECR 7404.5
ECHS1 7149.5
ACADVL 6798.5
ACADM 6715.5
HADHB 6348.5
MCAT 6165.5
HADH 5956.5
ACOT11 5798.5
ACOT7 5658.5
ACOT1 5390.0
ACOT2 5390.0
HADHA 5276.5
MCEE 5227.5
ACBD7 4955.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAA2 8392.5
PCCA 8219.5
ACADS 7996.5
DBI 7888.5
ECI1 7640.5
ACBD6 7437.5
MECR 7404.5
ECHS1 7149.5
ACADVL 6798.5
ACADM 6715.5
HADHB 6348.5
MCAT 6165.5
HADH 5956.5
ACOT11 5798.5
ACOT7 5658.5
ACOT1 5390.0
ACOT2 5390.0
HADHA 5276.5
MCEE 5227.5
ACBD7 4955.5
ACAD10 4554.5
ACADL 4411.5
NDUFAB1 4350.5
ACAD11 4281.5
ACOT13 4095.5
ACSF2 3919.5
MMUT 3678.5
THEM5 3298.5
MMAA 3070.5
PCCB 3066.5
ACSM3 2050.5
THEM4 1879.5
ACOT9 1689.5
DECR1 -1704.5
ACOT12 -3398.5
PCTP -5012.5


Vif-mediated degradation of APOBEC3G

Vif-mediated degradation of APOBEC3G
1391
set Vif-mediated degradation of APOBEC3G
setSize 50
pANOVA 1.8e-07
s.dist 0.427
p.adjustANOVA 8.09e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
ELOC 5925.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
ELOC 5925.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
CUL5 4698.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
RBX1 4159.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
PSMD9 -2755.0
PSMD13 -2775.5
ELOB -5059.5


Degradation of GLI1 by the proteasome

Degradation of GLI1 by the proteasome
285
set Degradation of GLI1 by the proteasome
setSize 56
pANOVA 1.8e-07
s.dist 0.403
p.adjustANOVA 8.09e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PRKACA 7262.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PRKACA 7262.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
SUFU 5369.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
RBX1 4159.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PRKACB 1490.5
PSMC6 1488.5
PSME3 1442.5
GLI1 620.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
ITCH -558.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
BTRC -1843.5
PSMD9 -2755.0
PSMD13 -2775.5
NUMB -8051.5


Vpu mediated degradation of CD4

Vpu mediated degradation of CD4
1399
set Vpu mediated degradation of CD4
setSize 49
pANOVA 1.85e-07
s.dist 0.431
p.adjustANOVA 8.09e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
CD4 1967.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
BTRC -1843.5
PSMD9 -2755.0
PSMD13 -2775.5


Mitochondrial protein import

Mitochondrial protein import
707
set Mitochondrial protein import
setSize 62
pANOVA 1.99e-07
s.dist 0.382
p.adjustANOVA 8.45e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
TIMM50 8913.5
ACO2 8817.5
LDHD 8757.5
CMC2 8574.5
PITRM1 8463.5
TOMM40 8333.5
FXN 8330.5
PMPCA 8171.5
SLC25A13 7672.5
SLC25A12 7665.5
GRPEL1 7654.5
CHCHD5 7532.5
TIMM44 7140.5
MTX1 6581.5
TOMM6 6247.5
TIMM23 6237.5
PMPCB 6193.5
TIMM8A 6184.5
SAMM50 6128.5
TIMM21 6056.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TIMM50 8913.5
ACO2 8817.5
LDHD 8757.5
CMC2 8574.5
PITRM1 8463.5
TOMM40 8333.5
FXN 8330.5
PMPCA 8171.5
SLC25A13 7672.5
SLC25A12 7665.5
GRPEL1 7654.5
CHCHD5 7532.5
TIMM44 7140.5
MTX1 6581.5
TOMM6 6247.5
TIMM23 6237.5
PMPCB 6193.5
TIMM8A 6184.5
SAMM50 6128.5
TIMM21 6056.5
CHCHD4 6017.5
CS 5894.5
TIMM8B 5797.5
HSPD1 5605.5
TAZ 5561.5
CYC1 5440.5
COQ2 5364.5
TIMM10 5314.5
SLC25A4 5264.5
HSPA9 5108.5
TIMM10B 5095.0
ATP5F1B 5063.5
CHCHD3 5047.5
NDUFB8 4615.0
VDAC1 4260.5
TIMM17A 3995.5
TIMM22 3837.5
OTC 3799.5
BCS1L 3714.5
TOMM20 3158.5
COA4 3056.5
TOMM22 2933.5
TOMM70 2806.5
IDH3G 2586.5
PAM16 1923.5
CHCHD7 1405.5
TIMM9 1333.5
COA6 1213.5
CMC4 1002.5
MTX2 965.5
COX17 646.5
TIMM13 27.5
DNAJC19 -270.5
COX19 -1192.5
GRPEL2 -4259.5
GFER -4610.5
HSCB -4732.5
TOMM7 -4954.5
ATP5F1A -6042.5
TIMM17B -6725.5
CHCHD10 -7851.5
CHCHD2 -7918.5


FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
381
set FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
setSize 52
pANOVA 2.46e-07
s.dist 0.414
p.adjustANOVA 1.02e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
RBX1 4159.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
AURKA -982.5
PSMB10 -1181.5
FBXL18 -1363.5
PSMF1 -1438.5
PSMD9 -2755.0
PSMD13 -2775.5
FBXL7 -3388.5


Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
819
set Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
setSize 63
pANOVA 2.79e-07
s.dist 0.374
p.adjustANOVA 1.12e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
EGLN1 8386.0
PSMC1 7622.5
EGLN2 7426.5
UBA52 7357.5
PSMA6 7345.5
CUL2 7195.5
UBE2D3 7189.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
ELOC 5925.5
PSMD11 5787.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
EGLN1 8386.0
PSMC1 7622.5
EGLN2 7426.5
UBA52 7357.5
PSMA6 7345.5
CUL2 7195.5
UBE2D3 7189.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
ELOC 5925.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
EGLN3 4702.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
RBX1 4159.5
PSMA7 3962.5
HIF3A 3792.5
EPAS1 3670.5
PSMD12 3211.5
UBE2D1 3169.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBE2D2 126.5
UBC 100.5
PSMA5 5.5
LIMD1 -224.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
WTIP -2033.5
PSMD9 -2755.0
PSMD13 -2775.5
VHL -4639.5
ELOB -5059.5
AJUBA -5412.5
HIF1A -6851.5


Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation
1038
set Regulation of activated PAK-2p34 by proteasome mediated degradation
setSize 47
pANOVA 2.88e-07
s.dist 0.433
p.adjustANOVA 1.13e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PAK2 449.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
PSMD9 -2755.0
PSMD13 -2775.5


Deubiquitination

Deubiquitination
297
set Deubiquitination
setSize 231
pANOVA 2.98e-07
s.dist 0.196
p.adjustANOVA 1.13e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
USP2 8778.5
USP20 8761.5
PSMB8 8750.5
PSMD1 8707.5
FOXO4 8664.5
RAD23A 8618.5
TNIP1 8492.5
USP25 8470.5
RHOT1 8433.5
USP4 8388.5
RUVBL1 8255.5
MAVS 8242.5
USP15 8228.5
NFRKB 8144.5
NOD1 8105.5
MAT2B 8081.5
ACTR8 8001.5
HGS 7865.5
FKBP8 7818.5
NEDD8 7736.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
USP2 8778.5
USP20 8761.5
PSMB8 8750.5
PSMD1 8707.5
FOXO4 8664.5
RAD23A 8618.5
TNIP1 8492.5
USP25 8470.5
RHOT1 8433.5
USP4 8388.5
RUVBL1 8255.5
MAVS 8242.5
USP15 8228.5
NFRKB 8144.5
NOD1 8105.5
MAT2B 8081.5
ACTR8 8001.5
HGS 7865.5
FKBP8 7818.5
NEDD8 7736.5
USP48 7686.5
PSMC1 7622.5
USP19 7579.5
USP5 7503.5
UBA52 7357.5
UIMC1 7349.5
PSMA6 7345.5
INO80E 7337.5
USP30 7330.5
TNIP2 7247.5
PTEN 7076.5
PSMD4 7024.5
USP13 7000.5
TAF10 6985.5
PSMB5 6910.5
PSMB9 6825.5
ESR1 6813.5
INO80B 6726.0
MDM2 6693.5
OTUD3 6668.5
TRAF2 6628.5
TNFAIP3 6624.5
VCP 6599.5
BAP1 6571.5
PSMA8 6529.5
KEAP1 6518.5
USP21 6463.5
PSME1 6431.5
VDAC2 6210.5
PSMD14 6156.5
INO80C 6134.5
MBD5 6111.5
PSMB6 6079.5
KAT2B 6027.5
USP47 6014.5
PSMB7 5988.5
OTUB1 5970.5
ATXN3 5958.0
ATXN3L 5958.0
PSMD7 5955.5
TGFBR2 5914.5
MUL1 5864.5
MYC 5828.5
PSMD11 5787.5
IKBKG 5786.5
PSMD8 5682.5
RAD23B 5659.5
PSMA4 5533.5
PSMD3 5512.5
TADA3 5438.5
USP12 5428.5
PSMC2 5421.5
KAT2A 5284.5
SMAD7 5247.5
PSME4 5222.5
PSMB1 5207.5
TRAF3 5171.5
RNF123 5138.5
USP14 5122.5
PSMD10 5093.5
PSMC3 4982.5
ADRM1 4905.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
OTUD5 4643.5
USP24 4607.5
H2AC1 4603.5
GATA3 4430.5
PSMD6 4428.5
PSMC5 4349.5
APC 4290.5
H2AC21 4285.5
VDAC1 4260.5
USP11 4212.5
AXIN2 4074.5
WDR48 4040.5
DDX58 4015.5
PSMA7 3962.5
JOSD1 3957.5
STAMBP 3927.5
USP10 3877.5
SUDS3 3848.5
OTUB2 3739.5
TNIP3 3734.5
TADA2B 3675.5
USP49 3646.5
BABAM1 3557.5
JOSD2 3490.5
USP16 3451.5
OTUD7B 3367.5
TAB1 3233.5
PSMD12 3211.5
UBE2D1 3169.5
TOMM20 3158.5
IL33 3098.5
RNF146 3078.5
EP300 2949.5
PSMB2 2944.5
VDAC3 2927.5
TOMM70 2806.5
RCE1 2747.5
SMURF2 2597.5
POLB 2550.5
PSME2 2547.5
H2BC1 2483.5
FOXK1 2423.5
YY1 2391.5
ZRANB1 2308.5
RPS27A 2261.5
YOD1 2244.5
RHOA 2014.5
TFPT 1969.5
PSMA1 1867.5
UCHL5 1761.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
H2BC11 1257.5
USP8 1256.5
MCRS1 1074.5
ARRB1 770.5
WDR20 500.5
SENP8 470.5
PSMB3 391.5
BARD1 384.5
CFTR 341.5
BIRC2 238.5
UBC 100.5
PSMA5 5.5
ATXN7 -150.5
CCP110 -194.5
IDE -266.5
TRAF6 -331.5
PSMA3 -754.5
ASXL2 -989.5
TRIM25 -1015.5
PSMB10 -1181.5
ACTL6A -1190.5
USP28 -1197.5
ARRB2 -1362.5
PSMF1 -1438.5
MBD6 -1439.5
TGFB1 -1494.5
STAM -1589.5
CDC25A -1611.5
RIPK2 -1709.5
USP44 -1803.5
STAM2 -1842.5
USP33 -1939.5
ACTR5 -1944.5
AR -1955.5
USP22 -2034.5
USP18 -2198.0
BRCC3 -2379.5
USP3 -2439.5
MDM4 -2459.5
TNKS2 -2539.5
USP34 -2548.5
PSMD9 -2755.0
USP9X -2762.5
PSMD13 -2775.5
STAMBPL1 -2799.5
INO80D -2837.5
IFIH1 -2885.5
UCHL1 -3161.5
ADRB2 -3195.5
HCFC1 -3268.5
NOD2 -3286.5
TAF9B -3457.5
SMAD3 -3534.5
OTUD7A -3546.5
MAP3K7 -3694.5
VCPIP1 -3803.5
SIAH2 -3808.5
MYSM1 -3819.5
RNF128 -3922.5
UCHL3 -4145.5
ASXL1 -4189.5
FOXK2 -4210.5
SKP2 -4252.5
SMAD1 -4336.5
PTRH2 -5069.5
USP7 -5134.5
SMAD4 -5135.5
USP42 -5582.5
H2BC3 -5930.5
RIPK1 -5961.5
TNKS -6095.5
USP37 -6101.5
H2BU1 -6178.5
BRCA1 -6186.5
KDM1B -6307.5
TGFBR1 -6311.5
HIF1A -6851.5
DDB2 -6883.5
H2BC12 -7021.5
CCNA1 -7120.5
INO80 -7269.5
CCNA2 -7508.5
BECN1 -7524.5
BIRC3 -7702.5
OGT -7946.5
NLRP3 -8069.5
ACTB -8079.5
CYLD -8088.5
CDC20 -8352.5
CLSPN -8372.5
SMAD2 -8431.5
CDK1 -8596.5


Interleukin-1 family signaling

Interleukin-1 family signaling
586
set Interleukin-1 family signaling
setSize 127
pANOVA 3.64e-07
s.dist 0.261
p.adjustANOVA 1.35e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
AGER 8956.5
PSMB8 8750.5
PSMD1 8707.5
SQSTM1 8697.5
NFKBIB 8429.5
IL4 8331.5
PTPN6 8246.5
NOD1 8105.5
NKIRAS2 7943.5
PTPN11 7913.5
APP 7804.5
IL18BP 7738.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
NKIRAS1 7353.5
PSMA6 7345.5
TNIP2 7247.5
PSMD4 7024.5
PSMB5 6910.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AGER 8956.5
PSMB8 8750.5
PSMD1 8707.5
SQSTM1 8697.5
NFKBIB 8429.5
IL4 8331.5
PTPN6 8246.5
NOD1 8105.5
NKIRAS2 7943.5
PTPN11 7913.5
APP 7804.5
IL18BP 7738.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
NKIRAS1 7353.5
PSMA6 7345.5
TNIP2 7247.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
TAB2 6793.5
PELI3 6700.5
IL1B 6648.5
IL36RN 6617.5
PSMA8 6529.5
PSME1 6431.5
MAP3K8 6329.5
TBK1 6213.5
PTPN14 6203.5
PSMD14 6156.5
PSMB6 6079.5
STAT3 6074.5
PSMB7 5988.5
PTPN18 5965.5
PSMD7 5955.5
NFKB2 5930.5
CUL1 5811.5
PSMD11 5787.5
IKBKG 5786.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
IL1RAP 5449.5
TAB3 5441.5
PSMC2 5421.5
MAP2K1 5275.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PTPN5 5043.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
IL13 4648.5
CASP1 4564.5
PSMD6 4428.5
PSMC5 4349.5
RBX1 4159.5
PSMA7 3962.5
IL18R1 3945.5
UBE2N 3887.0
MAP2K6 3880.5
TAB1 3233.5
PSMD12 3211.5
IL33 3098.5
PSMB2 2944.5
IRAK2 2926.5
PSME2 2547.5
MAP3K3 2535.5
NFKB1 2395.5
RPS27A 2261.5
PSMA1 1867.5
IL1F10 1737.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
MYD88 1336.5
TOLLIP 1309.5
IKBKB 1146.5
PTPN13 1079.5
IL1R2 1075.5
IL1RN 670.5
IL18RAP 586.5
IRAK1 408.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
TRAF6 -331.5
MAPK8 -572.5
PSMA3 -754.5
PTPN2 -1057.5
PSMB10 -1181.5
FBXW11 -1203.5
MAP2K4 -1376.5
PSMF1 -1438.5
IL36A -1550.5
RIPK2 -1709.5
PTPN23 -1727.5
PTPN9 -1763.5
BTRC -1843.5
IL1RL2 -2384.5
CHUK -2390.5
SIGIRR -2397.5
HMGB1 -2574.5
PSMD9 -2755.0
PSMD13 -2775.5
NOD2 -3286.5
SMAD3 -3534.5
MAP3K7 -3694.5
IL36B -3940.5
PELI2 -4274.5
IL1RAPL1 -4448.5
ALOX5 -4740.5
PTPN7 -5621.5
IRAK3 -5654.5
IL18 -5965.5
PELI1 -6202.5
RELA -6220.5
IRAK4 -6357.5
PTPN4 -6358.5
IL1R1 -7048.5
IL1A -7386.5
PTPN12 -7680.5
IL1RL1 -7942.5


GLI3 is processed to GLI3R by the proteasome

GLI3 is processed to GLI3R by the proteasome
459
set GLI3 is processed to GLI3R by the proteasome
setSize 56
pANOVA 3.98e-07
s.dist 0.392
p.adjustANOVA 1.44e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PRKACA 7262.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PRKACA 7262.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
SUFU 5369.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
RBX1 4159.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PRKACB 1490.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
GSK3B -787.5
PSMB10 -1181.5
PSMF1 -1438.5
BTRC -1843.5
PSMD9 -2755.0
PSMD13 -2775.5
CSNK1A1 -5751.5
GLI3 -7127.5


SCF-beta-TrCP mediated degradation of Emi1

SCF-beta-TrCP mediated degradation of Emi1
1095
set SCF-beta-TrCP mediated degradation of Emi1
setSize 52
pANOVA 4.35e-07
s.dist 0.405
p.adjustANOVA 1.53e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
FBXO5 2702.5
PSME2 2547.5
RPS27A 2261.5
FZR1 1968.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
BTRC -1843.5
PSMD9 -2755.0
PSMD13 -2775.5
CDC20 -8352.5


Cell surface interactions at the vascular wall

Cell surface interactions at the vascular wall
170
set Cell surface interactions at the vascular wall
setSize 155
pANOVA 4.47e-07
s.dist -0.235
p.adjustANOVA 1.54e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD244 -8468.5
APOB -8370.5
PPIA -8361.0
L1CAM -8213.5
CEACAM1 -8171.0
CEACAM3 -8171.0
CEACAM5 -8171.0
CEACAM6 -8171.0
CEACAM8 -8171.0
PSG1 -8171.0
PSG11 -8171.0
PSG2 -8171.0
PSG3 -8171.0
PSG4 -8171.0
PSG5 -8171.0
PSG6 -8171.0
PSG7 -8171.0
PSG8 -8171.0
PSG9 -8171.0
VPREB3 -8135.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD244 -8468.5
APOB -8370.5
PPIA -8361.0
L1CAM -8213.5
CEACAM1 -8171.0
CEACAM3 -8171.0
CEACAM5 -8171.0
CEACAM6 -8171.0
CEACAM8 -8171.0
PSG1 -8171.0
PSG11 -8171.0
PSG2 -8171.0
PSG3 -8171.0
PSG4 -8171.0
PSG5 -8171.0
PSG6 -8171.0
PSG7 -8171.0
PSG8 -8171.0
PSG9 -8171.0
VPREB3 -8135.5
CD99L2 -8057.5
CD44 -7979.5
YES1 -7705.5
CD47 -7660.5
NRAS -7625.5
ITGAM -7426.5
MAG -7389.5
SDC1 -7234.5
IGKV1-12 -7039.0
IGKV1-16 -7039.0
IGKV1-17 -7039.0
IGKV1-39 -7039.0
IGKV1-5 -7039.0
IGKV1D-12 -7039.0
IGKV1D-16 -7039.0
IGKV1D-39 -7039.0
SLC7A7 -6965.5
SDC2 -6795.5
KRAS -6786.5
ATP1B2 -6306.5
FN1 -6177.5
CXADR -6141.5
CAV1 -5750.5
IGLV3-16 -5675.5
IGLV3-22 -5675.5
IGLV3-25 -5675.5
IGLV3-27 -5675.5
GRB7 -5611.5
PROS1 -5462.5
CD2 -5386.5
SLC16A8 -5262.5
SPN -5108.5
IGLC1 -4828.0
IGLC2 -4828.0
IGLC3 -4828.0
IGLC7 -4828.0
IGLL1 -4828.0
TREM1 -4405.5
IGHV4-34 -4385.0
IGHV4-39 -4385.0
IGHV4-59 -4385.0
CD48 -4366.5
JCHAIN -4348.5
PIK3CB -4270.5
ITGAX -4225.5
PROCR -4108.5
ITGB3 -3942.0
FCAMR -3865.5
PIK3CA -3786.5
VPREB1 -3776.5
MERTK -3750.5
SDC4 -3567.5
LYN -3527.5
DOK2 -3469.5
ANGPT2 -3298.5
SLC7A5 -3157.5
SLC7A11 -3154.5
PLCG1 -3094.5
ATP1B3 -3029.5
ITGA6 -2918.5
IGHV2-5 -2844.5
IGHV2-70 -2844.5
GYPC -2758.5
LCK -2739.5
GLG1 -2576.5
TEK -2432.5
SRC -2361.5
MIF -2210.5
SLC7A8 -1980.5
ITGA4 -1928.5
SELP -1681.5
TGFB1 -1494.5
SLC3A2 -1390.5
PROC -1175.5
PICK1 -1117.5
SHC1 -1008.5
EPCAM -887.5
IGHV7-81 -695.0
CD177 -611.5
INPP5D -584.5
IGKV2-28 -517.5
IGKV2D-28 -517.5
IGKV2D-40 -517.5
F11R -514.5
SLC16A3 -371.5
SLC16A1 -369.5
FYN -339.5
ITGB2 145.5
SELE 342.5
IGKV4-1 362.5
SLC7A6 369.5
F2 644.5
GP6 928.5
SOS1 1229.5
JAM3 1395.5
SDC3 1408.5
PIK3R2 1532.0
FCER1G 1820.5
SELPLG 1885.5
ANGPT4 2123.5
CD84 2345.5
SLC7A9 2794.5
ANGPT1 3009.5
OLR1 3343.5
CD99 4293.5
JAM2 4714.5
SELL 4757.5
ITGA5 4984.5
PIK3R1 5011.5
TSPAN7 5291.0
ITGAL 5399.5
GRB2 5591.5
ESAM 5603.5
ITGB1 5760.5
PPIL2 5869.5
SLC7A10 5949.5
THBD 6089.5
ITGAV 6100.5
IGKV2-30 6283.0
IGKV2D-30 6283.0
GPC1 6312.5
GRB14 6551.5
SIRPA 6690.0
SIRPG 6690.0
IGLV6-57 6930.5
IGHM 7883.5
PTPN11 7913.5
ITGA3 8156.5
BSG 8186.5
PTPN6 8246.5
HRAS 8620.5
CD74 8687.5
ATP1B1 8849.5
IGKC 8857.5
GAS6 9006.5


Hedgehog ligand biogenesis

Hedgehog ligand biogenesis
528
set Hedgehog ligand biogenesis
setSize 61
pANOVA 5.34e-07
s.dist 0.371
p.adjustANOVA 1.8e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
SYVN1 7703.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
VCP 6599.5
PSMA8 6529.5
PSME1 6431.5
P4HB 6271.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
SYVN1 7703.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
VCP 6599.5
PSMA8 6529.5
PSME1 6431.5
P4HB 6271.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
OS9 4799.5
PSMC4 4751.5
PSMD2 4685.5
HHAT 4670.5
PSMD5 4655.5
SEL1L 4548.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
DERL2 3262.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
ERLEC1 2361.5
IHH 2289.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
ADAM17 -478.5
SHH -695.0
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
DHH -1812.5
PSMD9 -2755.0
PSMD13 -2775.5
DISP2 -5005.5
NOTUM -5332.5
SCUBE2 -6218.5


Degradation of DVL

Degradation of DVL
284
set Degradation of DVL
setSize 54
pANOVA 5.86e-07
s.dist 0.393
p.adjustANOVA 1.9e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
RBX1 4159.5
PSMA7 3962.5
HECW1 3566.5
PSMD12 3211.5
PSMB2 2944.5
DVL3 2855.5
PSME2 2547.5
RPS27A 2261.5
DVL2 2062.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
DVL1 1473.5
PSME3 1442.5
CUL3 572.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
KLHL12 -1721.5
PSMD9 -2755.0
PSMD13 -2775.5
DACT1 -3592.5


Regulation of RUNX2 expression and activity

Regulation of RUNX2 expression and activity
1026
set Regulation of RUNX2 expression and activity
setSize 69
pANOVA 6.03e-07
s.dist 0.347
p.adjustANOVA 1.9e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAT1 8891.5
PSMB8 8750.5
ESRRA 8712.5
PSMD1 8707.5
PPARGC1B 7660.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
ESR1 6813.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT1 8891.5
PSMB8 8750.5
ESRRA 8712.5
PSMD1 8707.5
PPARGC1B 7660.5
PSMC1 7622.5
SKP1 7381.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
ESR1 6813.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
NR3C1 5325.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
STUB1 5004.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
RBX1 4159.5
TWIST1 4084.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
DLX6 2658.5
PSME2 2547.5
BMP2 2527.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PPARGC1A 1116.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
DLX5 -96.5
PSMA3 -754.5
GSK3B -787.5
PSMB10 -1181.5
PSMF1 -1438.5
MSX2 -1752.5
WWP1 -2403.5
PSMD9 -2755.0
PSMD13 -2775.5
FBXW7 -3647.5
SMURF1 -3855.5
SKP2 -4252.5
CBFB -4500.5
RUNX2 -5866.5
HIVEP3 -7071.5


Dectin-1 mediated noncanonical NF-kB signaling

Dectin-1 mediated noncanonical NF-kB signaling
265
set Dectin-1 mediated noncanonical NF-kB signaling
setSize 59
pANOVA 6.05e-07
s.dist 0.376
p.adjustANOVA 1.9e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBE2M 7376.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
CCL17 6273.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
NFKB2 5930.5
CUL1 5811.5
PSMD11 5787.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
SKP1 7381.5
UBE2M 7376.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
CCL17 6273.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
NFKB2 5930.5
CUL1 5811.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
MAP3K14 2011.5
PSMA1 1867.5
UBA3 1735.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
RELB 1279.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
FBXW11 -1203.5
PSMF1 -1438.5
BTRC -1843.5
CHUK -2390.5
PSMD9 -2755.0
PSMD13 -2775.5
RELA -6220.5
CCL22 -7744.5


Cellular response to hypoxia

Cellular response to hypoxia
177
set Cellular response to hypoxia
setSize 72
pANOVA 6.2e-07
s.dist 0.34
p.adjustANOVA 1.91e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
VEGFA 8964.5
PSMB8 8750.5
PSMD1 8707.5
EGLN1 8386.0
PSMC1 7622.5
EGLN2 7426.5
UBA52 7357.5
PSMA6 7345.5
CUL2 7195.5
UBE2D3 7189.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
ELOC 5925.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VEGFA 8964.5
PSMB8 8750.5
PSMD1 8707.5
EGLN1 8386.0
PSMC1 7622.5
EGLN2 7426.5
UBA52 7357.5
PSMA6 7345.5
CUL2 7195.5
UBE2D3 7189.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
ELOC 5925.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
HIGD1A 5350.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
EGLN3 4702.5
CITED2 4699.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
RBX1 4159.5
PSMA7 3962.5
HIF3A 3792.5
HIF1AN 3788.5
EPAS1 3670.5
PSMD12 3211.5
UBE2D1 3169.5
EP300 2949.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBE2D2 126.5
UBC 100.5
PSMA5 5.5
LIMD1 -224.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
WTIP -2033.5
PSMD9 -2755.0
PSMD13 -2775.5
CREBBP -2899.5
CA9 -3419.5
VHL -4639.5
ARNT -4995.5
ELOB -5059.5
EPO -5264.5
AJUBA -5412.5
HIF1A -6851.5


Autodegradation of the E3 ubiquitin ligase COP1

Autodegradation of the E3 ubiquitin ligase COP1
102
set Autodegradation of the E3 ubiquitin ligase COP1
setSize 47
pANOVA 6.4e-07
s.dist 0.42
p.adjustANOVA 1.93e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 8750.5
PSMD1 8707.5
PSMC1 7622.5
UBA52 7357.5
PSMA6 7345.5
PSMD4 7024.5
PSMB5 6910.5
PSMB9 6825.5
PSMA8 6529.5
PSME1 6431.5
PSMD14 6156.5
PSMB6 6079.5
PSMB7 5988.5
PSMD7 5955.5
PSMD11 5787.5
PSMD8 5682.5
PSMA4 5533.5
PSMD3 5512.5
PSMC2 5421.5
PSME4 5222.5
PSMB1 5207.5
PSMD10 5093.5
PSMC3 4982.5
PSMA2 4823.0
PSMC4 4751.5
PSMD2 4685.5
PSMD5 4655.5
PSMD6 4428.5
PSMC5 4349.5
PSMA7 3962.5
PSMD12 3211.5
PSMB2 2944.5
PSME2 2547.5
RPS27A 2261.5
PSMA1 1867.5
PSMB4 1567.5
PSMC6 1488.5
PSME3 1442.5
PSMB3 391.5
UBC 100.5
PSMA5 5.5
PSMA3 -754.5
PSMB10 -1181.5
PSMF1 -1438.5
PSMD9 -2755.0
PSMD13 -2775.5
ATM -4881.5


FCGR3A-mediated phagocytosis

FCGR3A-mediated phagocytosis
387
set FCGR3A-mediated phagocytosis
setSize 87
pANOVA 7.68e-07
s.dist -0.307
p.adjustANOVA 2.18e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ARPC2 -8638.5
ARPC5 -8617.5
CYFIP2 -8558.5
MYO5A -8482.5
MYO9B -8423.5
WASF2 -8403.5
ACTB -8079.5
CD247 -8071.5
ACTR3 -7923.5
RAC1 -7765.5
YES1 -7705.5
SYK -7580.5
BTK -7424.5
VAV1 -7406.5
ELMO2 -7347.5
VAV3 -7293.5
ELMO1 -7076.5
IGKV1-12 -7039.0
IGKV1-16 -7039.0
IGKV1-17 -7039.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARPC2 -8638.5
ARPC5 -8617.5
CYFIP2 -8558.5
MYO5A -8482.5
MYO9B -8423.5
WASF2 -8403.5
ACTB -8079.5
CD247 -8071.5
ACTR3 -7923.5
RAC1 -7765.5
YES1 -7705.5
SYK -7580.5
BTK -7424.5
VAV1 -7406.5
ELMO2 -7347.5
VAV3 -7293.5
ELMO1 -7076.5
IGKV1-12 -7039.0
IGKV1-16 -7039.0
IGKV1-17 -7039.0
IGKV1-39 -7039.0
IGKV1-5 -7039.0
IGKV1D-12 -7039.0
IGKV1D-16 -7039.0
IGKV1D-39 -7039.0
ACTR2 -6872.5
MYO10 -6643.5
WAS -6573.5
CYFIP1 -6275.5
NCKAP1L -5905.5
DOCK1 -5681.5
IGLV3-16 -5675.5
IGLV3-22 -5675.5
IGLV3-25 -5675.5
IGLV3-27 -5675.5
PTK2 -5506.5
ARPC1B -5078.5
WIPF1 -5015.5
IGLC1 -4828.0
IGLC2 -4828.0
IGLC3 -4828.0
IGLC7 -4828.0
ABI1 -4717.5
ABI2 -4575.5
NCKIPSD -4420.5
IGHV4-34 -4385.0
IGHV4-39 -4385.0
IGHV4-59 -4385.0
WIPF2 -4347.5
LYN -3527.5
IGHV2-5 -2844.5
IGHV2-70 -2844.5
CDC42 -2813.5
WASL -2730.5
SRC -2361.5
NCKAP1 -1488.5
MYH9 -1301.5
CD3G -891.5
IGHV7-81 -695.0
MAPK1 -523.5
IGKV2-28 -517.5
IGKV2D-28 -517.5
IGKV2D-40 -517.5
FYN -339.5
ARPC3 305.5
IGKV4-1 362.5
HCK 1919.5
WASF1 2249.5
MAPK3 2999.5
ARPC4 3107.5
ACTG1 3383.5
BRK1 4083.5
FCGR3A 4854.0
ABL1 5165.5
NCK1 5332.5
CRK 5404.5
GRB2 5591.5
WIPF3 5919.5
IGKV2-30 6283.0
IGKV2D-30 6283.0
IGLV6-57 6930.5
BAIAP2 8026.5
FGR 8128.5
VAV2 8325.5
MYO1C 8565.5
WASF3 8828.5
IGKC 8857.5


Leishmania phagocytosis

Leishmania phagocytosis
636
set Leishmania phagocytosis
setSize 87
pANOVA 7.68e-07
s.dist -0.307
p.adjustANOVA 2.18e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ARPC2 -8638.5
ARPC5 -8617.5
CYFIP2 -8558.5
MYO5A -8482.5
MYO9B -8423.5
WASF2 -8403.5
ACTB -8079.5
CD247 -8071.5
ACTR3 -7923.5
RAC1 -7765.5
YES1 -7705.5
SYK -7580.5
BTK -7424.5
VAV1 -7406.5
ELMO2 -7347.5
VAV3 -7293.5
ELMO1 -7076.5
IGKV1-12 -7039.0
IGKV1-16 -7039.0
IGKV1-17 -7039.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARPC2 -8638.5
ARPC5 -8617.5
CYFIP2 -8558.5
MYO5A -8482.5
MYO9B -8423.5
WASF2 -8403.5
ACTB -8079.5
CD247 -8071.5
ACTR3 -7923.5
RAC1 -7765.5
YES1 -7705.5
SYK -7580.5
BTK -7424.5
VAV1 -7406.5
ELMO2 -7347.5
VAV3 -7293.5
ELMO1 -7076.5
IGKV1-12 -7039.0
IGKV1-16 -7039.0
IGKV1-17 -7039.0
IGKV1-39 -7039.0
IGKV1-5 -7039.0
IGKV1D-12 -7039.0
IGKV1D-16 -7039.0
IGKV1D-39 -7039.0
ACTR2 -6872.5
MYO10 -6643.5
WAS -6573.5
CYFIP1 -6275.5
NCKAP1L -5905.5
DOCK1 -5681.5
IGLV3-16 -5675.5
IGLV3-22 -5675.5
IGLV3-25 -5675.5
IGLV3-27 -5675.5
PTK2 -5506.5
ARPC1B -5078.5
WIPF1 -5015.5
IGLC1 -4828.0
IGLC2 -4828.0
IGLC3 -4828.0
IGLC7 -4828.0
ABI1 -4717.5
ABI2 -4575.5
NCKIPSD -4420.5
IGHV4-34 -4385.0
IGHV4-39 -4385.0
IGHV4-59 -4385.0
WIPF2 -4347.5
LYN -3527.5
IGHV2-5 -2844.5
IGHV2-70 -2844.5
CDC42 -2813.5
WASL -2730.5
SRC -2361.5
NCKAP1 -1488.5
MYH9 -1301.5
CD3G -891.5
IGHV7-81 -695.0
MAPK1 -523.5
IGKV2-28 -517.5
IGKV2D-28 -517.5
IGKV2D-40 -517.5
FYN -339.5
ARPC3 305.5
IGKV4-1 362.5
HCK 1919.5
WASF1 2249.5
MAPK3 2999.5
ARPC4 3107.5
ACTG1 3383.5
BRK1 4083.5
FCGR3A 4854.0
ABL1 5165.5
NCK1 5332.5
CRK 5404.5
GRB2 5591.5
WIPF3 5919.5
IGKV2-30 6283.0
IGKV2D-30 6283.0
IGLV6-57 6930.5
BAIAP2 8026.5
FGR 8128.5
VAV2 8325.5
MYO1C 8565.5
WASF3 8828.5
IGKC 8857.5


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] ggplot2_3.3.2               beeswarm_0.2.3             
##  [5] gtools_3.8.2                tibble_3.0.4               
##  [7] dplyr_1.0.2                 echarts4r_0.3.3            
##  [9] gplots_3.1.0                mitch_1.2.2                
## [11] DESeq2_1.30.0               SummarizedExperiment_1.20.0
## [13] Biobase_2.50.0              MatrixGenerics_1.2.0       
## [15] matrixStats_0.57.0          GenomicRanges_1.42.0       
## [17] GenomeInfoDb_1.26.0         IRanges_2.24.0             
## [19] S4Vectors_0.28.0            BiocGenerics_0.36.0        
## [21] reshape2_1.4.4             
## 
## loaded via a namespace (and not attached):
##  [1] httr_1.4.2             jsonlite_1.7.1         bit64_4.0.5           
##  [4] splines_4.0.3          assertthat_0.2.1       shiny_1.5.0           
##  [7] highr_0.8              blob_1.2.1             GenomeInfoDbData_1.2.4
## [10] yaml_2.2.1             backports_1.2.0        pillar_1.4.6          
## [13] RSQLite_2.2.1          lattice_0.20-41        glue_1.4.2            
## [16] digest_0.6.27          RColorBrewer_1.1-2     promises_1.1.1        
## [19] XVector_0.30.0         colorspace_2.0-0       htmltools_0.5.0       
## [22] httpuv_1.5.4           Matrix_1.2-18          plyr_1.8.6            
## [25] XML_3.99-0.5           pkgconfig_2.0.3        genefilter_1.72.0     
## [28] zlibbioc_1.36.0        purrr_0.3.4            xtable_1.8-4          
## [31] scales_1.1.1           later_1.1.0.1          BiocParallel_1.24.1   
## [34] annotate_1.68.0        generics_0.1.0         ellipsis_0.3.1        
## [37] withr_2.3.0            survival_3.2-7         magrittr_1.5          
## [40] crayon_1.3.4           mime_0.9               evaluate_0.14         
## [43] memoise_1.1.0          MASS_7.3-53            tools_4.0.3           
## [46] lifecycle_0.2.0        stringr_1.4.0          munsell_0.5.0         
## [49] locfit_1.5-9.4         DelayedArray_0.16.0    AnnotationDbi_1.52.0  
## [52] compiler_4.0.3         caTools_1.18.0         rlang_0.4.8           
## [55] grid_4.0.3             RCurl_1.98-1.2         htmlwidgets_1.5.2     
## [58] rmarkdown_2.5          bitops_1.0-6           testthat_3.0.0        
## [61] gtable_0.3.0           DBI_1.1.0              reshape_0.8.8         
## [64] R6_2.5.0               gridExtra_2.3          knitr_1.30            
## [67] fastmap_1.0.1          bit_4.0.4              rprojroot_1.3-2       
## [70] desc_1.2.0             KernSmooth_2.23-18     stringi_1.5.3         
## [73] Rcpp_1.0.5             vctrs_0.3.4            geneplotter_1.68.0    
## [76] tidyselect_1.1.0       xfun_0.19

END of report