Mitch Report

date generated: 2023-09-22

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
pol	174.97945
env	174.96945
tat	161.28311
gag	142.70074
nef	124.22267
vif	90.52759

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2630
num_genes_in_profile	10939
duplicated_genes_present	0
num_profile_genes_in_sets	6285
num_profile_genes_not_in_sets	4654

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-20.gmt

Gene set metrics

	Gene sets metrics
num_genesets	2630
num_genesets_excluded	1330
num_genesets_included	1300

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## https://haozhu233.github.io/kableExtra/ for details.

set	setSize	pANOVA	s.dist	p.adjustANOVA
Eukaryotic Translation Termination	90	2.34e-39	-0.799	3.04e-37
Viral mRNA Translation	87	1.30e-37	-0.794	9.97e-36
Eukaryotic Translation Elongation	90	7.27e-38	-0.783	6.30e-36
Peptide chain elongation	87	2.48e-36	-0.780	1.79e-34
Formation of a pool of free 40S subunits	98	4.92e-40	-0.773	7.11e-38
SRP-dependent cotranslational protein targeting to membrane	109	4.36e-44	-0.771	1.42e-41
SARS-CoV-1 modulates host translation machinery	36	1.67e-15	-0.767	2.35e-14
Selenocysteine synthesis	90	7.10e-36	-0.761	4.86e-34
Folding of actin by CCT/TriC	10	3.37e-05	-0.757	2.05e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	1.37e-35	-0.746	8.46e-34
SARS-CoV-2 modulates host translation machinery	47	8.64e-19	-0.746	2.39e-17
Formation of ATP by chemiosmotic coupling	18	6.58e-08	-0.735	5.45e-07
GTP hydrolysis and joining of the 60S ribosomal subunit	109	4.48e-39	-0.724	5.30e-37
Formation of the ternary complex, and subsequently, the 43S complex	50	1.00e-18	-0.722	2.71e-17
Selenoamino acid metabolism	101	2.25e-35	-0.714	1.27e-33
L13a-mediated translational silencing of Ceruloplasmin expression	108	1.11e-37	-0.714	8.98e-36
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	25	7.36e-10	-0.711	6.69e-09
Response of EIF2AK4 (GCN2) to amino acid deficiency	98	3.95e-34	-0.711	1.97e-32
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	1.97e-17	-0.708	4.42e-16
Regulation of expression of SLITs and ROBOs	155	2.56e-52	-0.707	1.11e-49
Regulation of ornithine decarboxylase (ODC)	49	1.23e-17	-0.706	2.92e-16
Mitochondrial translation elongation	88	2.82e-30	-0.705	1.18e-28
Prefoldin mediated transfer of substrate to CCT/TriC	24	2.91e-09	-0.700	2.54e-08
Cap-dependent Translation Initiation	116	9.08e-39	-0.699	8.43e-37
Eukaryotic Translation Initiation	116	9.08e-39	-0.699	8.43e-37
Vpu mediated degradation of CD4	50	1.86e-17	-0.695	4.25e-16
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	52	4.72e-18	-0.694	1.18e-16
Negative regulation of NOTCH4 signaling	53	3.73e-18	-0.689	9.52e-17
Mitochondrial translation initiation	88	5.03e-29	-0.689	1.92e-27
Mitochondrial translation termination	88	7.65e-29	-0.687	2.84e-27
Ubiquitin-dependent degradation of Cyclin D	50	4.94e-17	-0.685	1.00e-15
Somitogenesis	46	1.33e-15	-0.681	1.92e-14
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	49	1.63e-16	-0.681	3.02e-15
p53-Independent DNA Damage Response	49	1.63e-16	-0.681	3.02e-15
p53-Independent G1/S DNA damage checkpoint	49	1.63e-16	-0.681	3.02e-15
Vif-mediated degradation of APOBEC3G	53	1.49e-17	-0.677	3.46e-16
Autodegradation of the E3 ubiquitin ligase COP1	49	3.92e-16	-0.672	5.92e-15
SCF(Skp2)-mediated degradation of p27/p21	55	6.58e-18	-0.672	1.61e-16
Mitochondrial translation	94	2.43e-29	-0.671	9.86e-28
Hh mutants are degraded by ERAD	53	3.65e-17	-0.669	7.85e-16
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	4.34e-17	-0.667	9.10e-16
SCF-beta-TrCP mediated degradation of Emi1	51	1.95e-16	-0.666	3.45e-15
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	52	1.04e-16	-0.665	2.01e-15
Cross-presentation of soluble exogenous antigens (endosomes)	46	6.16e-15	-0.665	8.17e-14
Regulation of Apoptosis	51	2.89e-16	-0.662	4.75e-15
Formation of tubulin folding intermediates by CCT/TriC	18	1.21e-06	-0.661	8.76e-06
The role of GTSE1 in G2/M progression after G2 checkpoint	63	1.26e-19	-0.660	3.56e-18
Metabolism of polyamines	54	4.87e-17	-0.660	1.00e-15
Defective CFTR causes cystic fibrosis	57	1.24e-17	-0.654	2.92e-16
Degradation of DVL	52	3.80e-16	-0.653	5.88e-15

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Eukaryotic Translation Termination	90	2.34e-39	-0.799000	3.04e-37
Viral mRNA Translation	87	1.30e-37	-0.794000	9.97e-36
Eukaryotic Translation Elongation	90	7.27e-38	-0.783000	6.30e-36
Peptide chain elongation	87	2.48e-36	-0.780000	1.79e-34
Formation of a pool of free 40S subunits	98	4.92e-40	-0.773000	7.11e-38
SRP-dependent cotranslational protein targeting to membrane	109	4.36e-44	-0.771000	1.42e-41
SARS-CoV-1 modulates host translation machinery	36	1.67e-15	-0.767000	2.35e-14
Selenocysteine synthesis	90	7.10e-36	-0.761000	4.86e-34
Folding of actin by CCT/TriC	10	3.37e-05	-0.757000	2.05e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	1.37e-35	-0.746000	8.46e-34
SARS-CoV-2 modulates host translation machinery	47	8.64e-19	-0.746000	2.39e-17
Formation of ATP by chemiosmotic coupling	18	6.58e-08	-0.735000	5.45e-07
GTP hydrolysis and joining of the 60S ribosomal subunit	109	4.48e-39	-0.724000	5.30e-37
Formation of the ternary complex, and subsequently, the 43S complex	50	1.00e-18	-0.722000	2.71e-17
Selenoamino acid metabolism	101	2.25e-35	-0.714000	1.27e-33
L13a-mediated translational silencing of Ceruloplasmin expression	108	1.11e-37	-0.714000	8.98e-36
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	25	7.36e-10	-0.711000	6.69e-09
Response of EIF2AK4 (GCN2) to amino acid deficiency	98	3.95e-34	-0.711000	1.97e-32
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	1.97e-17	-0.708000	4.42e-16
Regulation of expression of SLITs and ROBOs	155	2.56e-52	-0.707000	1.11e-49
Regulation of ornithine decarboxylase (ODC)	49	1.23e-17	-0.706000	2.92e-16
Mitochondrial translation elongation	88	2.82e-30	-0.705000	1.18e-28
Prefoldin mediated transfer of substrate to CCT/TriC	24	2.91e-09	-0.700000	2.54e-08
Cap-dependent Translation Initiation	116	9.08e-39	-0.699000	8.43e-37
Eukaryotic Translation Initiation	116	9.08e-39	-0.699000	8.43e-37
Vpu mediated degradation of CD4	50	1.86e-17	-0.695000	4.25e-16
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	52	4.72e-18	-0.694000	1.18e-16
Negative regulation of NOTCH4 signaling	53	3.73e-18	-0.689000	9.52e-17
Mitochondrial translation initiation	88	5.03e-29	-0.689000	1.92e-27
Mitochondrial translation termination	88	7.65e-29	-0.687000	2.84e-27
Ubiquitin-dependent degradation of Cyclin D	50	4.94e-17	-0.685000	1.00e-15
Somitogenesis	46	1.33e-15	-0.681000	1.92e-14
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	49	1.63e-16	-0.681000	3.02e-15
p53-Independent DNA Damage Response	49	1.63e-16	-0.681000	3.02e-15
p53-Independent G1/S DNA damage checkpoint	49	1.63e-16	-0.681000	3.02e-15
Vif-mediated degradation of APOBEC3G	53	1.49e-17	-0.677000	3.46e-16
Autodegradation of the E3 ubiquitin ligase COP1	49	3.92e-16	-0.672000	5.92e-15
SCF(Skp2)-mediated degradation of p27/p21	55	6.58e-18	-0.672000	1.61e-16
Mitochondrial translation	94	2.43e-29	-0.671000	9.86e-28
Hh mutants are degraded by ERAD	53	3.65e-17	-0.669000	7.85e-16
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	4.34e-17	-0.667000	9.10e-16
SCF-beta-TrCP mediated degradation of Emi1	51	1.95e-16	-0.666000	3.45e-15
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	52	1.04e-16	-0.665000	2.01e-15
Cross-presentation of soluble exogenous antigens (endosomes)	46	6.16e-15	-0.665000	8.17e-14
Regulation of Apoptosis	51	2.89e-16	-0.662000	4.75e-15
Formation of tubulin folding intermediates by CCT/TriC	18	1.21e-06	-0.661000	8.76e-06
The role of GTSE1 in G2/M progression after G2 checkpoint	63	1.26e-19	-0.660000	3.56e-18
Metabolism of polyamines	54	4.87e-17	-0.660000	1.00e-15
Defective CFTR causes cystic fibrosis	57	1.24e-17	-0.654000	2.92e-16
Degradation of DVL	52	3.80e-16	-0.653000	5.88e-15
Translation	265	2.66e-74	-0.650000	3.46e-71
Asymmetric localization of PCP proteins	50	1.91e-15	-0.649000	2.67e-14
Ribosomal scanning and start codon recognition	57	3.68e-17	-0.645000	7.85e-16
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	121	1.93e-34	-0.644000	1.01e-32
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	3.49e-32	-0.643000	1.62e-30
Nonsense-Mediated Decay (NMD)	113	3.49e-32	-0.643000	1.62e-30
Hh mutants abrogate ligand secretion	54	4.79e-16	-0.638000	7.16e-15
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	58	7.75e-17	-0.633000	1.53e-15
Glutathione conjugation	19	2.01e-06	-0.630000	1.42e-05
Complex I biogenesis	57	2.03e-16	-0.629000	3.52e-15
Translation initiation complex formation	57	2.39e-16	-0.628000	4.03e-15
Respiratory electron transport	102	1.21e-27	-0.624000	4.37e-26
Autodegradation of Cdh1 by Cdh1:APC/C	62	5.21e-17	-0.615000	1.04e-15
Regulation of RUNX3 expression and activity	55	3.49e-15	-0.614000	4.69e-14
Orc1 removal from chromatin	60	2.27e-16	-0.613000	3.88e-15
Post-chaperonin tubulin folding pathway	14	7.69e-05	-0.610000	4.38e-04
Cristae formation	31	6.22e-09	-0.603000	5.32e-08
Hedgehog ligand biogenesis	57	3.50e-15	-0.603000	4.69e-14
Mitochondrial protein import	63	2.46e-16	-0.597000	4.10e-15
Degradation of AXIN	52	1.07e-13	-0.596000	1.22e-12
rRNA processing in the nucleus and cytosol	180	4.69e-43	-0.594000	1.22e-40
NIK–>noncanonical NF-kB signaling	57	8.54e-15	-0.594000	1.12e-13
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	6.48e-04	0.594000	3.24e-03
APC/C:Cdc20 mediated degradation of Securin	63	3.90e-16	-0.593000	5.92e-15
Major pathway of rRNA processing in the nucleolus and cytosol	170	3.03e-40	-0.590000	4.92e-38
CDK-mediated phosphorylation and removal of Cdc6	64	3.32e-16	-0.590000	5.39e-15
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	64	3.71e-16	-0.589000	5.81e-15
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	64	3.71e-16	-0.589000	5.81e-15
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	60	3.22e-15	-0.588000	4.45e-14
Stabilization of p53	54	7.61e-14	-0.588000	8.91e-13
APC/C:Cdc20 mediated degradation of mitotic proteins	66	1.67e-16	-0.587000	3.02e-15
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	66	1.67e-16	-0.587000	3.02e-15
Influenza Viral RNA Transcription and Replication	133	4.39e-31	-0.582000	1.97e-29
ER-Phagosome pathway	83	7.12e-20	-0.579000	2.06e-18
Degradation of GLI1 by the proteasome	56	6.42e-14	-0.579000	7.59e-13
Cohesin Loading onto Chromatin	10	1.55e-03	0.578000	7.26e-03
Mitotic Telophase/Cytokinesis	10	1.55e-03	0.578000	7.26e-03
Degradation of GLI2 by the proteasome	56	8.48e-14	-0.577000	9.76e-13
GLI3 is processed to GLI3R by the proteasome	56	8.48e-14	-0.577000	9.76e-13
Signaling by ROBO receptors	186	1.48e-41	-0.574000	2.75e-39
PCP/CE pathway	69	1.97e-16	-0.573000	3.45e-15
Gluconeogenesis	23	2.12e-06	-0.571000	1.48e-05
Dectin-1 mediated noncanonical NF-kB signaling	59	5.68e-14	-0.566000	6.83e-13
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	67	1.33e-15	-0.565000	1.92e-14
Cell-extracellular matrix interactions	13	4.26e-04	-0.564000	2.21e-03
The citric acid (TCA) cycle and respiratory electron transport	166	3.50e-35	-0.557000	1.89e-33
ABC transporter disorders	63	2.28e-14	-0.556000	2.90e-13
Regulation of APC/C activators between G1/S and early anaphase	69	1.66e-15	-0.555000	2.35e-14
Cholesterol biosynthesis	25	2.02e-06	-0.549000	1.42e-05
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	11	1.66e-03	-0.548000	7.68e-03
Cellular response to starvation	142	2.91e-29	-0.546000	1.15e-27
Myogenesis	15	2.55e-04	0.546000	1.35e-03
Regulation of PTEN mRNA translation	11	1.77e-03	0.544000	8.07e-03
ROS and RNS production in phagocytes	25	2.52e-06	-0.544000	1.75e-05
p53-Dependent G1 DNA Damage Response	58	1.03e-12	-0.541000	1.11e-11
p53-Dependent G1/S DNA damage checkpoint	58	1.03e-12	-0.541000	1.11e-11
Influenza Infection	152	1.26e-30	-0.541000	5.48e-29
Gap junction assembly	10	3.44e-03	-0.534000	1.41e-02
Transport of connexons to the plasma membrane	10	3.44e-03	-0.534000	1.41e-02
Switching of origins to a post-replicative state	77	9.55e-16	-0.530000	1.41e-14
Josephin domain DUBs	10	3.76e-03	-0.529000	1.50e-02
Protein hydroxylation	14	6.60e-04	-0.526000	3.27e-03
Aggrephagy	30	6.93e-07	-0.524000	5.24e-06
G1/S DNA Damage Checkpoints	59	5.18e-12	-0.520000	5.22e-11
Citric acid cycle (TCA cycle)	22	2.49e-05	-0.519000	1.57e-04
Regulation of RUNX2 expression and activity	63	1.71e-12	-0.514000	1.79e-11
Detoxification of Reactive Oxygen Species	28	2.56e-06	-0.514000	1.77e-05
APC/C-mediated degradation of cell cycle proteins	74	3.05e-14	-0.511000	3.77e-13
Regulation of mitotic cell cycle	74	3.05e-14	-0.511000	3.77e-13
Assembly of the pre-replicative complex	75	2.18e-14	-0.510000	2.80e-13
rRNA processing	201	1.66e-35	-0.509000	9.83e-34
FGFR2 mutant receptor activation	16	4.70e-04	-0.505000	2.39e-03
Signaling by FGFR2 IIIa TM	16	4.70e-04	-0.505000	2.39e-03
NRAGE signals death through JNK	36	1.62e-07	0.505000	1.30e-06
HDMs demethylate histones	21	6.83e-05	0.502000	3.94e-04
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	6.01e-03	0.502000	2.21e-02
FOXO-mediated transcription of cell cycle genes	11	3.96e-03	0.502000	1.57e-02
Transferrin endocytosis and recycling	22	4.65e-05	-0.502000	2.76e-04
Cellular response to hypoxia	67	1.33e-12	-0.501000	1.40e-11
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	10	6.16e-03	-0.500000	2.24e-02
Antigen processing-Cross presentation	97	2.38e-17	-0.498000	5.23e-16
mRNA Splicing - Minor Pathway	50	1.12e-09	-0.498000	1.01e-08
Regulation of CDH11 Expression and Function	15	8.50e-04	0.498000	4.09e-03
Regulation of RAS by GAPs	61	1.88e-11	-0.497000	1.84e-10
Activation of NF-kappaB in B cells	64	6.71e-12	-0.496000	6.71e-11
rRNA modification in the nucleus and cytosol	55	2.13e-10	-0.495000	1.99e-09
Formation of paraxial mesoderm	55	2.61e-10	-0.493000	2.43e-09
Synthesis of PIPs at the late endosome membrane	10	6.97e-03	0.493000	2.48e-02
Regulation of PTEN stability and activity	63	1.46e-11	-0.492000	1.44e-10
Regulation of NPAS4 gene expression	11	4.75e-03	0.492000	1.80e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	10	7.25e-03	-0.490000	2.56e-02
Insulin receptor recycling	22	6.94e-05	-0.490000	3.99e-04
Gap junction trafficking	19	2.58e-04	-0.484000	1.37e-03
UCH proteinases	81	5.54e-14	-0.484000	6.73e-13
Regulation of mRNA stability by proteins that bind AU-rich elements	83	2.94e-14	-0.483000	3.71e-13
ABC-family proteins mediated transport	78	2.66e-13	-0.479000	2.93e-12
Signaling by BMP	14	2.17e-03	0.473000	9.52e-03
Degradation of cysteine and homocysteine	10	9.69e-03	-0.472000	3.27e-02
PIWI-interacting RNA (piRNA) biogenesis	17	7.58e-04	-0.472000	3.69e-03
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	32	3.98e-06	-0.471000	2.66e-05
TNFR2 non-canonical NF-kB pathway	77	9.02e-13	-0.471000	9.85e-12
FCERI mediated NF-kB activation	74	3.21e-12	-0.469000	3.29e-11
Metabolism of amino acids and derivatives	263	9.06e-39	-0.468000	8.43e-37
LDL clearance	15	1.74e-03	-0.467000	8.02e-03
VLDLR internalisation and degradation	15	1.81e-03	-0.465000	8.19e-03
SARS-CoV-1-host interactions	88	4.92e-14	-0.465000	6.03e-13
PINK1-PRKN Mediated Mitophagy	21	2.42e-04	-0.463000	1.29e-03
Nuclear events mediated by NFE2L2	87	1.08e-13	-0.461000	1.22e-12
DNA Replication Pre-Initiation	85	2.12e-13	-0.461000	2.37e-12
RUNX1 regulates transcription of genes involved in differentiation of HSCs	61	5.13e-10	-0.460000	4.73e-09
Synthesis of PIPs at the early endosome membrane	15	2.17e-03	0.457000	9.52e-03
Hedgehog ‘on’ state	65	2.02e-10	-0.456000	1.91e-09
Pentose phosphate pathway	13	4.48e-03	-0.455000	1.74e-02
Synthesis of DNA	96	1.83e-14	-0.453000	2.38e-13
Signaling by NOTCH4	75	1.35e-11	-0.452000	1.34e-10
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	13	5.09e-03	-0.449000	1.91e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	41	7.00e-07	-0.448000	5.26e-06
Cyclin E associated events during G1/S transition	73	5.44e-11	-0.444000	5.24e-10
Metabolism of steroid hormones	16	2.18e-03	-0.443000	9.52e-03
Cyclin A:Cdk2-associated events at S phase entry	75	3.83e-11	-0.442000	3.71e-10
Gap junction trafficking and regulation	21	4.60e-04	-0.442000	2.36e-03
Signaling by cytosolic FGFR1 fusion mutants	17	1.77e-03	0.438000	8.07e-03
NRIF signals cell death from the nucleus	14	5.22e-03	-0.431000	1.96e-02
Purine catabolism	13	7.63e-03	-0.427000	2.68e-02
Nucleotide biosynthesis	11	1.43e-02	-0.427000	4.54e-02
Triglyceride catabolism	13	7.76e-03	-0.427000	2.72e-02
FGFR2 alternative splicing	24	3.36e-04	-0.423000	1.76e-03
DNA Replication	101	2.44e-13	-0.422000	2.71e-12
Mitophagy	28	1.13e-04	-0.422000	6.25e-04
Downstream signaling events of B Cell Receptor (BCR)	77	1.68e-10	-0.421000	1.60e-09
Synthesis of PIPs at the plasma membrane	44	1.34e-06	0.421000	9.62e-06
Regulation of Expression and Function of Type II Classical Cadherins	16	3.62e-03	0.420000	1.45e-02
Regulation of Homotypic Cell-Cell Adhesion	16	3.62e-03	0.420000	1.45e-02
Abortive elongation of HIV-1 transcript in the absence of Tat	23	5.77e-04	-0.415000	2.90e-03
Trafficking and processing of endosomal TLR	10	2.50e-02	-0.409000	7.03e-02
Metabolism of cofactors	16	4.62e-03	-0.409000	1.76e-02
Plasma lipoprotein clearance	29	1.57e-04	-0.406000	8.62e-04
Chaperone Mediated Autophagy	18	2.96e-03	-0.405000	1.24e-02
RND3 GTPase cycle	26	3.81e-04	0.403000	1.98e-03
Downstream TCR signaling	84	1.93e-10	-0.402000	1.83e-09
Interleukin-12 signaling	37	2.71e-05	-0.399000	1.69e-04
Transcriptional Regulation by NPAS4	24	7.41e-04	0.398000	3.62e-03
Signaling by FLT3 fusion proteins	18	3.58e-03	0.397000	1.45e-02
MAPK6/MAPK4 signaling	76	2.89e-09	-0.394000	2.54e-08
Sema3A PAK dependent Axon repulsion	13	1.46e-02	-0.391000	4.63e-02
Signaling by WNT in cancer	19	3.35e-03	0.389000	1.38e-02
PI3K Cascade	18	4.31e-03	0.389000	1.69e-02
Protein localization	149	3.49e-16	-0.388000	5.60e-15
Phase II - Conjugation of compounds	43	1.11e-05	-0.387000	7.24e-05
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	10	3.67e-02	-0.382000	9.64e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	12	2.25e-02	-0.381000	6.48e-02
APC truncation mutants have impaired AXIN binding	12	2.37e-02	0.377000	6.71e-02
AXIN missense mutants destabilize the destruction complex	12	2.37e-02	0.377000	6.71e-02
Signaling by AMER1 mutants	12	2.37e-02	0.377000	6.71e-02
Signaling by APC mutants	12	2.37e-02	0.377000	6.71e-02
Signaling by AXIN mutants	12	2.37e-02	0.377000	6.71e-02
Truncations of AMER1 destabilize the destruction complex	12	2.37e-02	0.377000	6.71e-02
Interleukin-6 signaling	10	4.05e-02	0.374000	1.05e-01
FGFR1 mutant receptor activation	20	3.98e-03	0.372000	1.57e-02
RHOB GTPase cycle	47	1.07e-05	0.372000	6.96e-05
Suppression of phagosomal maturation	12	2.68e-02	-0.369000	7.47e-02
Beta-catenin phosphorylation cascade	14	1.70e-02	0.368000	5.25e-02
Glycogen storage diseases	11	3.47e-02	-0.368000	9.24e-02
CTNNB1 S33 mutants aren’t phosphorylated	13	2.22e-02	0.366000	6.42e-02
CTNNB1 S37 mutants aren’t phosphorylated	13	2.22e-02	0.366000	6.42e-02
CTNNB1 S45 mutants aren’t phosphorylated	13	2.22e-02	0.366000	6.42e-02
CTNNB1 T41 mutants aren’t phosphorylated	13	2.22e-02	0.366000	6.42e-02
Signaling by CTNNB1 phospho-site mutants	13	2.22e-02	0.366000	6.42e-02
Signaling by GSK3beta mutants	13	2.22e-02	0.366000	6.42e-02
Regulation of beta-cell development	16	1.18e-02	0.364000	3.86e-02
Sulfur amino acid metabolism	19	6.11e-03	-0.363000	2.23e-02
Activation of BAD and translocation to mitochondria	14	1.88e-02	-0.363000	5.67e-02
mRNA Splicing - Major Pathway	200	1.29e-18	-0.362000	3.34e-17
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	19	6.43e-03	-0.361000	2.33e-02
Hedgehog ‘off’ state	89	4.25e-09	-0.361000	3.66e-08
Host Interactions of HIV factors	126	3.02e-12	-0.361000	3.11e-11
PI Metabolism	65	5.10e-07	0.361000	3.93e-06
RORA activates gene expression	18	8.13e-03	0.360000	2.82e-02
Selective autophagy	66	4.22e-07	-0.360000	3.27e-06
Transcriptional regulation by RUNX2	90	3.63e-09	-0.360000	3.15e-08
Activation of AMPK downstream of NMDARs	16	1.30e-02	-0.359000	4.24e-02
NF-kB is activated and signals survival	11	3.97e-02	-0.358000	1.03e-01
Generation of second messenger molecules	18	8.53e-03	-0.358000	2.95e-02
Diseases of carbohydrate metabolism	23	2.96e-03	-0.358000	1.24e-02
Interleukin-12 family signaling	42	6.33e-05	-0.357000	3.67e-04
TCR signaling	98	1.09e-09	-0.357000	9.84e-09
mRNA Splicing	208	1.07e-18	-0.356000	2.83e-17
HSF1 activation	23	3.30e-03	-0.354000	1.36e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	11	4.29e-02	0.353000	1.10e-01
Metabolism of RNA	683	2.42e-54	-0.352000	1.57e-51
Metabolic disorders of biological oxidation enzymes	16	1.50e-02	-0.351000	4.72e-02
Chondroitin sulfate biosynthesis	10	5.62e-02	0.349000	1.35e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	49	2.60e-05	-0.348000	1.63e-04
G2/M Checkpoints	106	6.77e-10	-0.347000	6.20e-09
APC/C:Cdc20 mediated degradation of Cyclin B	20	7.43e-03	-0.346000	2.62e-02
p75NTR recruits signalling complexes	11	4.78e-02	-0.345000	1.20e-01
G1/S Transition	103	1.71e-09	-0.344000	1.51e-08
G alpha (12/13) signalling events	47	4.66e-05	0.344000	2.76e-04
Pre-NOTCH Transcription and Translation	30	1.13e-03	0.344000	5.39e-03
Degradation of beta-catenin by the destruction complex	75	2.85e-07	-0.343000	2.23e-06
tRNA processing in the mitochondrion	18	1.17e-02	0.343000	3.86e-02
Glyoxylate metabolism and glycine degradation	19	9.70e-03	-0.343000	3.27e-02
Formation of TC-NER Pre-Incision Complex	53	1.87e-05	-0.340000	1.19e-04
Inhibition of DNA recombination at telomere	20	8.58e-03	-0.340000	2.96e-02
Glycogen synthesis	10	6.35e-02	-0.339000	1.49e-01
Signaling by FGFR1 in disease	26	2.78e-03	0.339000	1.19e-02
RHO GTPases activate IQGAPs	22	5.95e-03	-0.339000	2.20e-02
APC-Cdc20 mediated degradation of Nek2A	20	8.99e-03	-0.338000	3.07e-02
Insulin processing	16	1.95e-02	0.337000	5.83e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	34	6.65e-04	0.337000	3.27e-03
Sealing of the nuclear envelope (NE) by ESCRT-III	22	6.17e-03	-0.337000	2.24e-02
WNT5A-dependent internalization of FZD4	12	4.32e-02	-0.337000	1.11e-01
Notch-HLH transcription pathway	26	3.01e-03	0.336000	1.26e-02
NOTCH4 Intracellular Domain Regulates Transcription	14	2.94e-02	0.336000	8.06e-02
Regulation of BACH1 activity	11	5.38e-02	-0.336000	1.32e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	18	1.39e-02	0.335000	4.44e-02
mRNA decay by 3’ to 5’ exoribonuclease	12	4.47e-02	-0.335000	1.14e-01
Regulation of RUNX1 Expression and Activity	17	1.75e-02	0.333000	5.36e-02
KEAP1-NFE2L2 pathway	112	1.29e-09	-0.333000	1.15e-08
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	18	1.48e-02	-0.332000	4.68e-02
RAS processing	20	1.05e-02	-0.331000	3.50e-02
Interleukin-6 family signaling	11	5.91e-02	0.329000	1.40e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	3.19e-03	-0.328000	1.33e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	3.19e-03	-0.328000	1.33e-02
Diseases associated with glycosylation precursor biosynthesis	15	2.82e-02	-0.327000	7.76e-02
IRS-related events triggered by IGF1R	23	6.71e-03	0.327000	2.42e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	59	1.47e-05	-0.327000	9.49e-05
Interconversion of nucleotide di- and triphosphates	23	6.79e-03	-0.326000	2.44e-02
Pyroptosis	22	8.14e-03	-0.326000	2.82e-02
Endosomal Sorting Complex Required For Transport (ESCRT)	30	2.04e-03	-0.326000	9.08e-03
CLEC7A (Dectin-1) signaling	93	7.11e-08	-0.324000	5.78e-07
Formation of the Early Elongation Complex	33	1.32e-03	-0.323000	6.22e-03
Formation of the HIV-1 Early Elongation Complex	33	1.32e-03	-0.323000	6.22e-03
NR1H2 and NR1H3-mediated signaling	39	4.82e-04	0.323000	2.45e-03
BMAL1:CLOCK,NPAS2 activates circadian gene expression	22	8.91e-03	0.322000	3.05e-02
Pausing and recovery of Tat-mediated HIV elongation	31	1.91e-03	-0.322000	8.57e-03
Tat-mediated HIV elongation arrest and recovery	31	1.91e-03	-0.322000	8.57e-03
Cellular response to chemical stress	187	5.88e-14	-0.319000	7.01e-13
Attenuation phase	19	1.60e-02	-0.319000	4.99e-02
Heme signaling	38	6.70e-04	0.319000	3.29e-03
HIV elongation arrest and recovery	32	1.79e-03	-0.319000	8.13e-03
Pausing and recovery of HIV elongation	32	1.79e-03	-0.319000	8.13e-03
Chemokine receptors bind chemokines	10	8.11e-02	-0.319000	1.83e-01
Iron uptake and transport	45	2.25e-04	-0.318000	1.21e-03
NPAS4 regulates expression of target genes	13	4.72e-02	0.318000	1.19e-01
PKMTs methylate histone lysines	37	8.30e-04	0.318000	4.03e-03
Axon guidance	358	1.15e-24	-0.317000	3.75e-23
DNA Damage Recognition in GG-NER	37	8.50e-04	-0.317000	4.09e-03
Neutrophil degranulation	378	1.50e-25	-0.315000	5.00e-24
mRNA Capping	29	3.57e-03	-0.313000	1.45e-02
Nephrin family interactions	15	3.63e-02	0.312000	9.58e-02
Lysosome Vesicle Biogenesis	32	2.25e-03	-0.312000	9.79e-03
Nervous system development	370	1.93e-24	-0.311000	6.13e-23
RNA Polymerase III Chain Elongation	17	2.69e-02	-0.310000	7.48e-02
IRS-mediated signalling	22	1.22e-02	0.309000	4.00e-02
Platelet degranulation	76	3.44e-06	-0.308000	2.34e-05
RHO GTPases activate PAKs	18	2.35e-02	-0.308000	6.71e-02
Interleukin-1 signaling	103	6.86e-08	-0.308000	5.61e-07
TP53 Regulates Transcription of Caspase Activators and Caspases	10	9.16e-02	0.308000	2.02e-01
Ca2+ pathway	36	1.40e-03	0.308000	6.60e-03
Pyruvate metabolism	25	7.91e-03	-0.307000	2.76e-02
SUMOylation of immune response proteins	11	7.87e-02	-0.306000	1.79e-01
Role of LAT2/NTAL/LAB on calcium mobilization	14	4.74e-02	0.306000	1.19e-01
The NLRP3 inflammasome	15	4.13e-02	-0.304000	1.06e-01
FOXO-mediated transcription of cell death genes	14	4.87e-02	0.304000	1.21e-01
mTORC1-mediated signalling	24	1.00e-02	-0.304000	3.37e-02
RNA Polymerase II Transcription Termination	62	3.75e-05	-0.303000	2.27e-04
Gastrulation	68	1.65e-05	-0.302000	1.06e-04
Translesion Synthesis by POLH	17	3.12e-02	-0.302000	8.45e-02
Diseases associated with N-glycosylation of proteins	19	2.32e-02	-0.301000	6.66e-02
Metabolism of porphyrins	19	2.36e-02	-0.300000	6.71e-02
Recycling pathway of L1	33	2.88e-03	-0.300000	1.22e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	16	3.84e-02	-0.299000	1.00e-01
Signaling by Erythropoietin	23	1.35e-02	0.298000	4.35e-02
p75NTR signals via NF-kB	14	5.51e-02	-0.296000	1.34e-01
ALK mutants bind TKIs	12	7.63e-02	0.296000	1.76e-01
Translocation of ZAP-70 to Immunological synapse	10	1.06e-01	-0.295000	2.27e-01
Basigin interactions	17	3.62e-02	-0.294000	9.56e-02
RHOJ GTPase cycle	45	6.63e-04	0.294000	3.27e-03
RNA Polymerase I Transcription Termination	23	1.52e-02	-0.292000	4.78e-02
Arachidonic acid metabolism	22	1.82e-02	-0.291000	5.51e-02
TP53 Regulates Transcription of Death Receptors and Ligands	10	1.12e-01	0.290000	2.37e-01
IGF1R signaling cascade	24	1.39e-02	0.290000	4.44e-02
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	24	1.39e-02	0.290000	4.44e-02
MHC class II antigen presentation	92	1.61e-06	-0.290000	1.14e-05
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	27	9.33e-03	-0.289000	3.17e-02
Response of Mtb to phagocytosis	21	2.20e-02	-0.289000	6.42e-02
FCERI mediated Ca+2 mobilization	24	1.48e-02	0.288000	4.68e-02
Response to elevated platelet cytosolic Ca2+	80	9.18e-06	-0.287000	6.06e-05
Disorders of transmembrane transporters	119	6.85e-08	-0.287000	5.61e-07
PRC2 methylates histones and DNA	13	7.73e-02	0.283000	1.78e-01
SARS-CoV-1 Infection	131	2.61e-08	-0.282000	2.17e-07
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	4.43e-03	-0.282000	1.73e-02
Dual incision in TC-NER	62	1.25e-04	-0.282000	6.89e-04
Gap-filling DNA repair synthesis and ligation in GG-NER	22	2.22e-02	-0.282000	6.42e-02
MyD88 deficiency (TLR2/4)	14	6.98e-02	-0.280000	1.62e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	34	4.77e-03	0.280000	1.80e-02
Beta-catenin independent WNT signaling	104	8.59e-07	-0.280000	6.31e-06
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	11	1.08e-01	-0.280000	2.30e-01
alpha-linolenic acid (ALA) metabolism	11	1.08e-01	-0.280000	2.30e-01
Cell recruitment (pro-inflammatory response)	21	2.68e-02	-0.279000	7.46e-02
Purinergic signaling in leishmaniasis infection	21	2.68e-02	-0.279000	7.46e-02
RND1 GTPase cycle	27	1.20e-02	0.279000	3.94e-02
RNA Polymerase I Promoter Escape	25	1.57e-02	-0.279000	4.92e-02
Protein folding	70	5.59e-05	-0.279000	3.29e-04
Plasma lipoprotein assembly	12	9.56e-02	-0.278000	2.08e-01
Processing of Capped Intron-Containing Pre-mRNA	274	3.41e-15	-0.278000	4.67e-14
Signaling by the B Cell Receptor (BCR)	101	1.49e-06	-0.278000	1.06e-05
MicroRNA (miRNA) biogenesis	24	1.90e-02	-0.277000	5.72e-02
Mitotic G1 phase and G1/S transition	116	2.79e-07	-0.277000	2.20e-06
Cytosolic iron-sulfur cluster assembly	11	1.15e-01	-0.275000	2.40e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	61	2.17e-04	-0.274000	1.17e-03
tRNA Aminoacylation	21	2.97e-02	-0.274000	8.11e-02
HIV Infection	219	3.66e-12	-0.274000	3.72e-11
Signaling by Hedgehog	111	7.54e-07	-0.272000	5.57e-06
Calnexin/calreticulin cycle	25	1.86e-02	-0.272000	5.62e-02
VxPx cargo-targeting to cilium	17	5.25e-02	0.272000	1.29e-01
Late endosomal microautophagy	30	1.04e-02	-0.270000	3.50e-02
Heme biosynthesis	12	1.05e-01	-0.270000	2.25e-01
COPI-mediated anterograde transport	81	2.75e-05	-0.270000	1.71e-04
FASTK family proteins regulate processing and stability of mitochondrial RNAs	17	5.44e-02	0.270000	1.33e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	75	6.16e-05	-0.268000	3.60e-04
Insulin receptor signalling cascade	27	1.65e-02	0.267000	5.11e-02
Mitochondrial iron-sulfur cluster biogenesis	13	9.76e-02	-0.265000	2.12e-01
RUNX3 regulates NOTCH signaling	13	9.86e-02	0.265000	2.14e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	43	2.80e-03	-0.264000	1.19e-02
HIV Transcription Elongation	43	2.80e-03	-0.264000	1.19e-02
Tat-mediated elongation of the HIV-1 transcript	43	2.80e-03	-0.264000	1.19e-02
PD-1 signaling	14	8.82e-02	-0.263000	1.96e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	2.59e-03	-0.263000	1.12e-02
E3 ubiquitin ligases ubiquitinate target proteins	41	3.74e-03	-0.262000	1.50e-02
S Phase	130	2.75e-07	-0.262000	2.18e-06
Transcriptional regulation by RUNX3	87	2.62e-05	-0.261000	1.64e-04
Biological oxidations	85	3.33e-05	-0.261000	2.04e-04
Binding and Uptake of Ligands by Scavenger Receptors	20	4.47e-02	-0.259000	1.14e-01
N-Glycan antennae elongation	11	1.37e-01	0.259000	2.74e-01
Nuclear Receptor transcription pathway	29	1.62e-02	0.258000	5.06e-02
Termination of translesion DNA synthesis	27	2.06e-02	-0.258000	6.12e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	13	1.09e-01	-0.257000	2.31e-01
Plasma lipoprotein assembly, remodeling, and clearance	48	2.15e-03	-0.256000	9.52e-03
Separation of Sister Chromatids	145	1.10e-07	-0.256000	8.90e-07
Interleukin-1 family signaling	122	1.10e-06	-0.256000	8.02e-06
Recognition of DNA damage by PCNA-containing replication complex	26	2.42e-02	-0.256000	6.82e-02
RHOC GTPase cycle	55	1.08e-03	0.255000	5.17e-03
C-type lectin receptors (CLRs)	112	3.56e-06	-0.254000	2.41e-05
Signaling by PDGFR in disease	19	5.55e-02	0.254000	1.35e-01
HIV Transcription Initiation	42	4.56e-03	-0.253000	1.74e-02
RNA Polymerase II HIV Promoter Escape	42	4.56e-03	-0.253000	1.74e-02
RNA Polymerase II Promoter Escape	42	4.56e-03	-0.253000	1.74e-02
RNA Polymerase II Transcription Initiation	42	4.56e-03	-0.253000	1.74e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	42	4.56e-03	-0.253000	1.74e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	42	4.56e-03	-0.253000	1.74e-02
Acyl chain remodelling of PC	10	1.66e-01	0.253000	3.13e-01
IRAK1 recruits IKK complex	13	1.16e-01	-0.252000	2.41e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	13	1.16e-01	-0.252000	2.41e-01
Inositol phosphate metabolism	29	1.93e-02	0.251000	5.78e-02
Cellular responses to stress	623	5.36e-26	-0.251000	1.88e-24
Chaperonin-mediated protein folding	65	4.92e-04	-0.250000	2.49e-03
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	16	8.35e-02	0.250000	1.87e-01
Smooth Muscle Contraction	26	2.77e-02	-0.250000	7.66e-02
RAC1 GTPase cycle	133	7.17e-07	0.250000	5.36e-06
TP53 Regulates Metabolic Genes	82	1.00e-04	-0.249000	5.61e-04
Cellular responses to stimuli	631	6.06e-26	-0.249000	2.07e-24
CDC42 GTPase cycle	110	7.03e-06	0.248000	4.69e-05
RHOQ GTPase cycle	46	3.63e-03	0.248000	1.45e-02
Class I peroxisomal membrane protein import	18	6.92e-02	-0.247000	1.61e-01
Impaired BRCA2 binding to PALB2	19	6.25e-02	0.247000	1.47e-01
Infection with Mycobacterium tuberculosis	24	3.66e-02	-0.247000	9.63e-02
Telomere Maintenance	53	1.93e-03	-0.246000	8.63e-03
Metabolism of nucleotides	76	2.10e-04	-0.246000	1.14e-03
Retrograde neurotrophin signalling	10	1.78e-01	-0.246000	3.28e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	1.78e-01	-0.246000	3.29e-01
Amyloid fiber formation	34	1.32e-02	-0.246000	4.28e-02
Regulation of MECP2 expression and activity	27	2.77e-02	0.245000	7.66e-02
Prolonged ERK activation events	12	1.42e-01	0.245000	2.82e-01
Nucleotide Excision Repair	105	1.56e-05	-0.245000	1.00e-04
SARS-CoV-1 activates/modulates innate immune responses	36	1.12e-02	-0.244000	3.71e-02
PCNA-Dependent Long Patch Base Excision Repair	17	8.29e-02	-0.243000	1.86e-01
Dual Incision in GG-NER	38	9.60e-03	-0.243000	3.26e-02
Regulation of innate immune responses to cytosolic DNA	11	1.64e-01	-0.242000	3.10e-01
Signaling by FLT3 ITD and TKD mutants	14	1.17e-01	0.242000	2.43e-01
Miscellaneous transport and binding events	16	9.40e-02	0.242000	2.05e-01
Nicotinamide salvaging	13	1.32e-01	0.242000	2.66e-01
IRAK4 deficiency (TLR2/4)	15	1.05e-01	-0.242000	2.25e-01
RNA Polymerase III Transcription Termination	20	6.17e-02	-0.241000	1.46e-01
Downregulation of ERBB2 signaling	18	7.66e-02	-0.241000	1.76e-01
Collagen degradation	21	5.61e-02	-0.241000	1.35e-01
Azathioprine ADME	17	8.67e-02	-0.240000	1.93e-01
Mitotic Anaphase	185	2.01e-08	-0.240000	1.69e-07
Mitotic Metaphase and Anaphase	185	2.01e-08	-0.240000	1.69e-07
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	33	1.71e-02	-0.240000	5.27e-02
mRNA decay by 5’ to 3’ exoribonuclease	15	1.09e-01	-0.239000	2.31e-01
Cell-cell junction organization	33	1.76e-02	0.239000	5.37e-02
mRNA 3’-end processing	55	2.30e-03	-0.238000	9.95e-03
Viral Infection Pathways	613	3.07e-23	-0.238000	9.50e-22
Interleukin receptor SHC signaling	17	8.97e-02	0.238000	1.99e-01
HDR through MMEJ (alt-NHEJ)	10	1.93e-01	0.238000	3.51e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	41	8.73e-03	-0.237000	2.99e-02
DNA Damage/Telomere Stress Induced Senescence	22	5.48e-02	0.237000	1.33e-01
Metabolism of nitric oxide: NOS3 activation and regulation	10	1.97e-01	-0.236000	3.56e-01
TICAM1, RIP1-mediated IKK complex recruitment	18	8.39e-02	-0.235000	1.88e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	15	1.17e-01	-0.234000	2.42e-01
Formation of the beta-catenin:TCF transactivating complex	24	4.74e-02	0.234000	1.19e-01
Signaling by FGFR2	49	4.69e-03	-0.234000	1.78e-02
G2/M Transition	159	4.21e-07	-0.233000	3.27e-06
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	13	1.47e-01	-0.233000	2.87e-01
Peroxisomal lipid metabolism	24	4.91e-02	-0.232000	1.22e-01
Downstream signaling of activated FGFR1	13	1.50e-01	0.231000	2.88e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	1.36e-01	-0.230000	2.73e-01
Rap1 signalling	12	1.68e-01	-0.230000	3.16e-01
CD28 dependent PI3K/Akt signaling	19	8.35e-02	0.229000	1.87e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	30	2.98e-02	0.229000	8.11e-02
Signaling by FGFR2 in disease	25	4.74e-02	-0.229000	1.19e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	16	1.13e-01	-0.229000	2.37e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	16	1.13e-01	-0.229000	2.37e-01
Mitotic G2-G2/M phases	160	6.68e-07	-0.228000	5.08e-06
Resolution of D-Loop Structures	23	5.86e-02	0.228000	1.40e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	23	5.86e-02	0.228000	1.40e-01
Programmed Cell Death	176	2.08e-07	-0.228000	1.66e-06
Receptor Mediated Mitophagy	11	1.91e-01	-0.228000	3.49e-01
Metalloprotease DUBs	16	1.15e-01	-0.228000	2.40e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	12	1.73e-01	-0.227000	3.21e-01
Defective Intrinsic Pathway for Apoptosis	20	7.91e-02	-0.227000	1.80e-01
KSRP (KHSRP) binds and destabilizes mRNA	15	1.31e-01	-0.225000	2.65e-01
rRNA processing in the mitochondrion	21	7.42e-02	0.225000	1.72e-01
Synthesis of IP3 and IP4 in the cytosol	14	1.46e-01	0.225000	2.87e-01
Interleukin-20 family signaling	14	1.46e-01	0.224000	2.87e-01
SARS-CoV-2-host interactions	169	5.50e-07	-0.224000	4.20e-06
TICAM1-dependent activation of IRF3/IRF7	11	1.98e-01	-0.224000	3.59e-01
Phospholipid metabolism	144	3.87e-06	0.224000	2.61e-05
Intra-Golgi traffic	39	1.64e-02	0.222000	5.10e-02
Global Genome Nucleotide Excision Repair (GG-NER)	79	6.52e-04	-0.222000	3.25e-03
Apoptosis	149	3.08e-06	-0.222000	2.12e-05
Metabolism	1410	9.63e-42	-0.222000	2.09e-39
RHO GTPases activate CIT	14	1.52e-01	-0.221000	2.90e-01
Collagen formation	31	3.34e-02	-0.221000	8.96e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	26	5.24e-02	-0.220000	1.29e-01
Interleukin-2 family signaling	29	4.09e-02	0.219000	1.06e-01
Regulated Necrosis	51	6.99e-03	-0.219000	2.48e-02
Translesion synthesis by REV1	15	1.43e-01	-0.218000	2.83e-01
Triglyceride metabolism	19	9.96e-02	-0.218000	2.15e-01
Phosphorylation of the APC/C	16	1.31e-01	-0.218000	2.65e-01
Nucleotide catabolism	25	5.96e-02	-0.218000	1.41e-01
Signaling by EGFR in Cancer	17	1.21e-01	-0.217000	2.50e-01
Synthesis of PIPs at the Golgi membrane	14	1.60e-01	0.217000	3.03e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	27	5.16e-02	-0.217000	1.27e-01
Adherens junctions interactions	25	6.10e-02	0.217000	1.44e-01
Carnitine metabolism	11	2.14e-01	0.216000	3.79e-01
Resolution of Abasic Sites (AP sites)	32	3.44e-02	-0.216000	9.19e-02
RHO GTPases activate PKNs	26	5.77e-02	-0.215000	1.39e-01
HSF1-dependent transactivation	26	5.83e-02	-0.215000	1.40e-01
Spry regulation of FGF signaling	16	1.37e-01	-0.215000	2.74e-01
NOTCH3 Intracellular Domain Regulates Transcription	16	1.37e-01	0.215000	2.74e-01
Telomere Extension By Telomerase	16	1.38e-01	-0.215000	2.74e-01
Macroautophagy	118	6.17e-05	-0.214000	3.60e-04
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	20	1.00e-01	-0.212000	2.16e-01
Circadian Clock	59	4.85e-03	0.212000	1.83e-02
EPH-Ephrin signaling	62	3.92e-03	-0.212000	1.56e-02
Signal regulatory protein family interactions	11	2.24e-01	-0.212000	3.90e-01
Maturation of nucleoprotein 9683610	11	2.25e-01	0.211000	3.91e-01
Fc epsilon receptor (FCERI) signaling	118	8.09e-05	-0.211000	4.57e-04
Metabolism of proteins	1348	1.25e-35	-0.209000	8.13e-34
Interleukin-15 signaling	11	2.32e-01	0.208000	4.01e-01
The role of Nef in HIV-1 replication and disease pathogenesis	24	7.76e-02	-0.208000	1.78e-01
EPH-ephrin mediated repulsion of cells	28	5.68e-02	-0.208000	1.37e-01
Sphingolipid de novo biosynthesis	24	7.83e-02	0.208000	1.79e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	16	1.50e-01	-0.208000	2.88e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	16	1.50e-01	-0.208000	2.88e-01
Post-translational modification: synthesis of GPI-anchored proteins	37	2.90e-02	-0.208000	7.96e-02
RHOA GTPase cycle	104	3.14e-04	0.205000	1.65e-03
COPI-independent Golgi-to-ER retrograde traffic	40	2.50e-02	-0.205000	7.03e-02
Fatty acyl-CoA biosynthesis	24	8.24e-02	-0.205000	1.86e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	18	1.34e-01	-0.204000	2.70e-01
Cell death signalling via NRAGE, NRIF and NADE	53	1.02e-02	0.204000	3.44e-02
Paracetamol ADME	10	2.65e-01	-0.204000	4.36e-01
L1CAM interactions	63	5.38e-03	-0.203000	2.01e-02
Infectious disease	747	1.51e-20	-0.203000	4.56e-19
Diseases of metabolism	129	7.23e-05	-0.203000	4.14e-04
Maternal to zygotic transition (MZT)	50	1.33e-02	0.203000	4.28e-02
IRE1alpha activates chaperones	43	2.18e-02	-0.202000	6.42e-02
Pre-NOTCH Expression and Processing	45	1.99e-02	0.201000	5.95e-02
Mitochondrial calcium ion transport	20	1.21e-01	-0.201000	2.49e-01
Activated NOTCH1 Transmits Signal to the Nucleus	22	1.04e-01	-0.200000	2.24e-01
Innate Immune System	749	4.69e-20	-0.200000	1.39e-18
Negative regulation of FLT3	11	2.51e-01	-0.200000	4.21e-01
Maturation of nucleoprotein 9694631	15	1.81e-01	0.200000	3.32e-01
Formation of Incision Complex in GG-NER	42	2.58e-02	-0.199000	7.23e-02
Mismatch Repair	14	2.01e-01	-0.197000	3.62e-01
Pexophagy	11	2.58e-01	-0.197000	4.27e-01
Downstream signaling of activated FGFR2	11	2.58e-01	0.197000	4.27e-01
Downstream signaling of activated FGFR3	11	2.58e-01	0.197000	4.27e-01
Downstream signaling of activated FGFR4	11	2.58e-01	0.197000	4.27e-01
MAP2K and MAPK activation	32	5.39e-02	-0.197000	1.32e-01
Transcriptional Regulation by MECP2	39	3.36e-02	0.197000	8.98e-02
ER to Golgi Anterograde Transport	125	1.61e-04	-0.196000	8.81e-04
FLT3 signaling in disease	25	9.02e-02	0.196000	1.99e-01
Signaling by ERBB2 TMD/JMD mutants	10	2.84e-01	-0.196000	4.56e-01
Signaling by NODAL	12	2.42e-01	0.195000	4.12e-01
Negative regulation of the PI3K/AKT network	57	1.09e-02	0.195000	3.60e-02
Collagen biosynthesis and modifying enzymes	19	1.41e-01	-0.195000	2.80e-01
Cell Cycle Checkpoints	193	3.38e-06	-0.195000	2.31e-05
MECP2 regulates neuronal receptors and channels	10	2.87e-01	0.194000	4.60e-01
RHO GTPases Activate WASPs and WAVEs	34	5.03e-02	-0.194000	1.25e-01
Processing of Capped Intronless Pre-mRNA	27	8.11e-02	-0.194000	1.83e-01
NOTCH1 Intracellular Domain Regulates Transcription	41	3.21e-02	0.194000	8.68e-02
PI3K/AKT Signaling in Cancer	50	1.80e-02	0.194000	5.49e-02
COPI-dependent Golgi-to-ER retrograde traffic	66	6.72e-03	-0.193000	2.42e-02
PKR-mediated signaling	59	1.05e-02	-0.193000	3.50e-02
Caspase activation via extrinsic apoptotic signalling pathway	21	1.27e-01	0.193000	2.59e-01
ADP signalling through P2Y purinoceptor 12	12	2.50e-01	-0.192000	4.20e-01
CTLA4 inhibitory signaling	17	1.71e-01	0.192000	3.19e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	17	1.71e-01	-0.192000	3.19e-01
Neurodegenerative Diseases	17	1.71e-01	-0.192000	3.19e-01
Signaling by FGFR	56	1.32e-02	-0.192000	4.28e-02
Chromosome Maintenance	70	5.71e-03	-0.191000	2.12e-02
Fatty acid metabolism	113	4.56e-04	-0.191000	2.35e-03
RND2 GTPase cycle	26	9.20e-02	0.191000	2.02e-01
Autophagy	130	1.80e-04	-0.191000	9.77e-04
RHOV GTPase cycle	28	8.26e-02	0.190000	1.86e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	2.56e-01	0.190000	4.27e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	10	3.00e-01	-0.189000	4.70e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	10	3.00e-01	-0.189000	4.70e-01
PTEN Regulation	128	2.32e-04	-0.189000	1.24e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript	69	6.93e-03	-0.188000	2.47e-02
RET signaling	22	1.28e-01	0.188000	2.61e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	20	1.47e-01	0.187000	2.87e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	20	1.47e-01	0.187000	2.87e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	20	1.47e-01	0.187000	2.87e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	20	1.47e-01	0.187000	2.87e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	20	1.47e-01	0.187000	2.87e-01
Glycosphingolipid catabolism	24	1.13e-01	-0.187000	2.37e-01
HS-GAG biosynthesis	16	1.96e-01	0.187000	3.56e-01
RAF/MAP kinase cascade	168	3.25e-05	-0.186000	2.00e-04
XBP1(S) activates chaperone genes	41	4.09e-02	-0.185000	1.06e-01
M-decay: degradation of maternal mRNAs by maternally stored factors	37	5.29e-02	0.184000	1.30e-01
Transcription of the HIV genome	65	1.08e-02	-0.183000	3.58e-02
Cytosolic sensors of pathogen-associated DNA	56	1.79e-02	-0.183000	5.46e-02
Neddylation	198	1.00e-05	-0.183000	6.57e-05
Metabolism of steroids	100	1.64e-03	-0.183000	7.61e-03
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	12	2.74e-01	0.182000	4.46e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	12	2.74e-01	0.182000	4.46e-01
Nuclear Envelope (NE) Reassembly	62	1.31e-02	-0.182000	4.26e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1	12	2.76e-01	0.182000	4.49e-01
Asparagine N-linked glycosylation	249	9.54e-07	-0.181000	6.96e-06
G beta:gamma signalling through BTK	11	3.00e-01	-0.180000	4.70e-01
DNA Damage Bypass	41	4.59e-02	-0.180000	1.16e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	1.86e-01	-0.180000	3.41e-01
Deadenylation of mRNA	22	1.44e-01	0.180000	2.84e-01
Regulation of TP53 Activity through Association with Co-factors	10	3.26e-01	0.179000	4.96e-01
Constitutive Signaling by AKT1 E17K in Cancer	23	1.37e-01	0.179000	2.74e-01
Glucose metabolism	74	7.78e-03	-0.179000	2.72e-02
Glycosphingolipid metabolism	30	9.20e-02	-0.178000	2.02e-01
Oxidative Stress Induced Senescence	56	2.16e-02	0.178000	6.38e-02
Translesion synthesis by POLK	16	2.19e-01	-0.178000	3.84e-01
Transport of Mature Transcript to Cytoplasm	78	6.84e-03	-0.177000	2.45e-02
Nef mediated downregulation of MHC class I complex cell surface expression	10	3.32e-01	-0.177000	5.00e-01
Nucleotide salvage	20	1.70e-01	-0.177000	3.18e-01
Cargo concentration in the ER	24	1.37e-01	-0.176000	2.74e-01
Constitutive Signaling by Aberrant PI3K in Cancer	26	1.22e-01	0.175000	2.51e-01
Antimicrobial peptides	15	2.40e-01	-0.175000	4.11e-01
MAPK1/MAPK3 signaling	172	7.89e-05	-0.175000	4.48e-04
Post-translational protein phosphorylation	44	4.49e-02	-0.175000	1.14e-01
Cytoprotection by HMOX1	58	2.15e-02	-0.175000	6.37e-02
Mitochondrial Fatty Acid Beta-Oxidation	31	9.28e-02	-0.175000	2.04e-01
Chromatin modifying enzymes	189	3.87e-05	0.174000	2.32e-04
Chromatin organization	189	3.87e-05	0.174000	2.32e-04
RNA Polymerase III Transcription Initiation From Type 3 Promoter	26	1.24e-01	-0.174000	2.55e-01
Cargo recognition for clathrin-mediated endocytosis	71	1.13e-02	-0.174000	3.73e-02
Frs2-mediated activation	10	3.41e-01	0.174000	5.09e-01
Activation of G protein gated Potassium channels	11	3.20e-01	-0.173000	4.89e-01
G protein gated Potassium channels	11	3.20e-01	-0.173000	4.89e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	11	3.20e-01	-0.173000	4.89e-01
Synthesis of very long-chain fatty acyl-CoAs	15	2.46e-01	-0.173000	4.18e-01
RHO GTPases Activate NADPH Oxidases	19	1.92e-01	-0.173000	3.50e-01
NCAM signaling for neurite out-growth	25	1.35e-01	0.173000	2.73e-01
Assembly of collagen fibrils and other multimeric structures	19	1.93e-01	-0.172000	3.51e-01
Metabolism of non-coding RNA	50	3.56e-02	-0.172000	9.44e-02
snRNP Assembly	50	3.56e-02	-0.172000	9.44e-02
Base Excision Repair	38	6.84e-02	-0.171000	1.60e-01
Translesion synthesis by POLI	16	2.37e-01	-0.171000	4.07e-01
Amino acids regulate mTORC1	44	5.07e-02	-0.170000	1.25e-01
TRAF3-dependent IRF activation pathway	13	2.88e-01	0.170000	4.61e-01
RHOF GTPase cycle	29	1.13e-01	0.170000	2.37e-01
Base-Excision Repair, AP Site Formation	15	2.57e-01	-0.169000	4.27e-01
MTOR signalling	39	6.96e-02	-0.168000	1.62e-01
PKA-mediated phosphorylation of CREB	14	2.78e-01	0.168000	4.51e-01
Cytochrome c-mediated apoptotic response	12	3.16e-01	0.167000	4.86e-01
Scavenging by Class A Receptors	10	3.61e-01	-0.167000	5.30e-01
B-WICH complex positively regulates rRNA expression	24	1.59e-01	-0.166000	3.02e-01
MAPK targets/ Nuclear events mediated by MAP kinases	28	1.29e-01	0.166000	2.62e-01
InlB-mediated entry of Listeria monocytogenes into host cell	12	3.22e-01	-0.165000	4.91e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	11	3.44e-01	-0.165000	5.13e-01
Gastrin-CREB signalling pathway via PKC and MAPK	14	2.87e-01	0.164000	4.60e-01
Protein ubiquitination	60	2.87e-02	-0.164000	7.89e-02
HDACs deacetylate histones	32	1.10e-01	0.163000	2.33e-01
RHOU GTPase cycle	34	1.00e-01	0.163000	2.16e-01
Endogenous sterols	13	3.11e-01	-0.162000	4.83e-01
Activation of GABAB receptors	17	2.47e-01	-0.162000	4.18e-01
GABA B receptor activation	17	2.47e-01	-0.162000	4.18e-01
Nuclear events stimulated by ALK signaling in cancer	19	2.22e-01	-0.162000	3.87e-01
Golgi-to-ER retrograde transport	97	6.07e-03	-0.162000	2.23e-02
Peroxisomal protein import	54	4.03e-02	-0.161000	1.05e-01
Synthesis of PC	19	2.23e-01	0.161000	3.90e-01
Formation of RNA Pol II elongation complex	56	3.77e-02	-0.161000	9.86e-02
RNA Polymerase II Transcription Elongation	56	3.77e-02	-0.161000	9.86e-02
RHO GTPase cycle	328	7.30e-07	0.160000	5.42e-06
Uptake and actions of bacterial toxins	17	2.53e-01	-0.160000	4.24e-01
Retrograde transport at the Trans-Golgi-Network	48	5.57e-02	0.160000	1.35e-01
TRAF6 mediated IRF7 activation	15	2.85e-01	0.159000	4.58e-01
Viral Messenger RNA Synthesis	43	7.25e-02	-0.158000	1.68e-01
Transcriptional regulation of granulopoiesis	21	2.10e-01	0.158000	3.76e-01
Synthesis of glycosylphosphatidylinositol (GPI)	15	2.91e-01	-0.158000	4.62e-01
ERK/MAPK targets	20	2.24e-01	0.157000	3.90e-01
Complement cascade	19	2.36e-01	-0.157000	4.05e-01
Extension of Telomeres	38	9.70e-02	-0.156000	2.11e-01
Signal transduction by L1	16	2.81e-01	-0.156000	4.55e-01
Protein methylation	14	3.14e-01	-0.155000	4.86e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	50	5.78e-02	0.155000	1.39e-01
Growth hormone receptor signaling	15	2.98e-01	0.155000	4.70e-01
Membrane binding and targetting of GAG proteins	14	3.16e-01	-0.155000	4.86e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	3.16e-01	-0.155000	4.86e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	29	1.50e-01	-0.155000	2.88e-01
Unfolded Protein Response (UPR)	79	1.81e-02	-0.154000	5.49e-02
Regulation of TLR by endogenous ligand	13	3.38e-01	-0.153000	5.06e-01
Senescence-Associated Secretory Phenotype (SASP)	44	7.89e-02	-0.153000	1.80e-01
Regulated proteolysis of p75NTR	10	4.04e-01	-0.153000	5.70e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	45	7.71e-02	-0.152000	1.77e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	58	4.50e-02	-0.152000	1.14e-01
Initiation of Nuclear Envelope (NE) Reformation	17	2.82e-01	-0.151000	4.55e-01
Integrin cell surface interactions	35	1.28e-01	-0.149000	2.60e-01
Synthesis of PA	24	2.07e-01	0.149000	3.71e-01
G beta:gamma signalling through CDC42	13	3.53e-01	-0.149000	5.21e-01
SUMOylation	150	1.76e-03	0.148000	8.07e-03
IKK complex recruitment mediated by RIP1	23	2.18e-01	-0.148000	3.84e-01
Negative regulation of FGFR2 signaling	17	2.90e-01	-0.148000	4.62e-01
Negative regulation of FGFR3 signaling	17	2.90e-01	-0.148000	4.62e-01
Negative regulation of FGFR4 signaling	17	2.90e-01	-0.148000	4.62e-01
TCF dependent signaling in response to WNT	117	5.82e-03	-0.148000	2.16e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	17	2.92e-01	-0.148000	4.63e-01
SUMOylation of transcription cofactors	40	1.07e-01	0.148000	2.27e-01
Interleukin-7 signaling	11	3.98e-01	0.147000	5.65e-01
Defective pyroptosis	13	3.60e-01	0.147000	5.28e-01
Assembly and cell surface presentation of NMDA receptors	21	2.45e-01	-0.147000	4.16e-01
Carboxyterminal post-translational modifications of tubulin	22	2.34e-01	-0.147000	4.03e-01
Constitutive Signaling by Overexpressed ERBB2	10	4.23e-01	-0.146000	5.88e-01
Sensory processing of sound	30	1.66e-01	-0.146000	3.14e-01
SARS-CoV-2 Infection	246	8.90e-05	-0.146000	5.01e-04
Transport to the Golgi and subsequent modification	146	2.47e-03	-0.146000	1.07e-02
FOXO-mediated transcription	45	9.24e-02	0.145000	2.03e-01
DARPP-32 events	21	2.50e-01	0.145000	4.20e-01
Interleukin-10 signaling	24	2.20e-01	-0.145000	3.85e-01
Signaling by Hippo	15	3.32e-01	0.145000	5.00e-01
SUMO E3 ligases SUMOylate target proteins	144	2.90e-03	0.144000	1.22e-02
RNA Polymerase II Pre-transcription Events	74	3.27e-02	-0.144000	8.81e-02
COPII-mediated vesicle transport	58	5.85e-02	-0.144000	1.40e-01
Formation of Fibrin Clot (Clotting Cascade)	10	4.34e-01	-0.143000	6.00e-01
Potassium Channels	21	2.57e-01	-0.143000	4.27e-01
Signaling by NTRK3 (TRKC)	12	3.92e-01	-0.143000	5.60e-01
RNA Polymerase III Transcription Initiation	34	1.53e-01	-0.142000	2.92e-01
Signaling by high-kinase activity BRAF mutants	29	1.87e-01	-0.142000	3.42e-01
Signaling by KIT in disease	16	3.27e-01	0.142000	4.96e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	16	3.27e-01	0.142000	4.96e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	25	2.21e-01	0.141000	3.87e-01
Drug ADME	40	1.22e-01	-0.141000	2.51e-01
p38MAPK events	11	4.17e-01	-0.141000	5.85e-01
Signaling by Interleukins	307	2.35e-05	-0.141000	1.49e-04
Ub-specific processing proteases	140	4.20e-03	-0.141000	1.65e-02
Downregulation of TGF-beta receptor signaling	24	2.34e-01	-0.140000	4.03e-01
Diseases of glycosylation	66	4.88e-02	-0.140000	1.21e-01
Developmental Biology	592	9.97e-09	-0.140000	8.48e-08
Cobalamin (Cbl, vitamin B12) transport and metabolism	11	4.23e-01	-0.140000	5.88e-01
Endosomal/Vacuolar pathway	10	4.45e-01	-0.140000	6.03e-01
tRNA modification in the nucleus and cytosol	36	1.48e-01	-0.139000	2.87e-01
activated TAK1 mediates p38 MAPK activation	21	2.70e-01	-0.139000	4.44e-01
Apoptotic cleavage of cellular proteins	27	2.12e-01	0.139000	3.77e-01
ER Quality Control Compartment (ERQC)	20	2.82e-01	-0.139000	4.55e-01
Formation of WDR5-containing histone-modifying complexes	40	1.29e-01	0.139000	2.62e-01
Beta-oxidation of very long chain fatty acids	10	4.49e-01	-0.138000	6.07e-01
Netrin-1 signaling	21	2.73e-01	0.138000	4.46e-01
tRNA processing in the nucleus	55	7.75e-02	-0.138000	1.78e-01
Signaling by NTRK2 (TRKB)	18	3.12e-01	0.138000	4.84e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	37	1.48e-01	-0.137000	2.87e-01
Signaling by RAS mutants	37	1.48e-01	-0.137000	2.87e-01
Signaling by moderate kinase activity BRAF mutants	37	1.48e-01	-0.137000	2.87e-01
Signaling downstream of RAS mutants	37	1.48e-01	-0.137000	2.87e-01
Signaling by NOTCH	148	4.36e-03	-0.136000	1.71e-02
RIPK1-mediated regulated necrosis	29	2.05e-01	-0.136000	3.69e-01
Regulation of necroptotic cell death	29	2.05e-01	-0.136000	3.69e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	17	3.32e-01	0.136000	5.00e-01
Diseases associated with the TLR signaling cascade	26	2.32e-01	-0.136000	4.01e-01
Diseases of Immune System	26	2.32e-01	-0.136000	4.01e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	18	3.22e-01	0.135000	4.91e-01
PLC beta mediated events	34	1.74e-01	0.135000	3.23e-01
Acyl chain remodelling of PE	10	4.61e-01	0.135000	6.18e-01
EGFR downregulation	20	2.98e-01	-0.134000	4.70e-01
Mitochondrial biogenesis	82	3.59e-02	-0.134000	9.51e-02
Inflammasomes	19	3.12e-01	-0.134000	4.84e-01
PERK regulates gene expression	28	2.21e-01	-0.134000	3.87e-01
EPHB-mediated forward signaling	33	1.85e-01	-0.133000	3.40e-01
GPER1 signaling	29	2.16e-01	-0.133000	3.81e-01
Regulation of Complement cascade	17	3.47e-01	-0.132000	5.16e-01
PKA activation in glucagon signalling	11	4.49e-01	0.132000	6.07e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	64	6.91e-02	-0.132000	1.61e-01
Removal of the Flap Intermediate	12	4.32e-01	-0.131000	5.98e-01
Platelet activation, signaling and aggregation	167	3.59e-03	-0.131000	1.45e-02
M Phase	291	1.33e-04	-0.131000	7.34e-04
Processing of SMDT1	14	3.98e-01	-0.131000	5.65e-01
DCC mediated attractive signaling	10	4.75e-01	0.131000	6.28e-01
HIV Life Cycle	144	7.05e-03	-0.130000	2.50e-02
Transcriptional Regulation by E2F6	30	2.17e-01	0.130000	3.82e-01
SARS-CoV Infections	345	3.69e-05	-0.130000	2.24e-04
Phase I - Functionalization of compounds	39	1.61e-01	-0.130000	3.04e-01
IRAK2 mediated activation of TAK1 complex	10	4.77e-01	-0.130000	6.30e-01
MAPK family signaling cascades	201	1.60e-03	-0.130000	7.45e-03
RAB GEFs exchange GTP for GDP on RABs	81	4.40e-02	0.130000	1.12e-01
SUMOylation of intracellular receptors	22	2.93e-01	0.130000	4.63e-01
Signaling by CSF1 (M-CSF) in myeloid cells	28	2.41e-01	0.128000	4.12e-01
Processing and activation of SUMO	10	4.84e-01	-0.128000	6.35e-01
NoRC negatively regulates rRNA expression	39	1.68e-01	-0.128000	3.16e-01
GAB1 signalosome	10	4.85e-01	0.127000	6.36e-01
Positive epigenetic regulation of rRNA expression	39	1.75e-01	-0.126000	3.24e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	17	3.72e-01	0.125000	5.39e-01
ERKs are inactivated	12	4.54e-01	-0.125000	6.10e-01
Syndecan interactions	15	4.02e-01	-0.125000	5.69e-01
Negative epigenetic regulation of rRNA expression	41	1.69e-01	-0.124000	3.16e-01
G0 and Early G1	14	4.21e-01	0.124000	5.87e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	11	4.75e-01	0.124000	6.28e-01
Late Phase of HIV Life Cycle	132	1.43e-02	-0.124000	4.56e-02
Signaling by NOTCH1	58	1.03e-01	0.124000	2.22e-01
GABA receptor activation	19	3.51e-01	-0.124000	5.19e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	10	4.99e-01	-0.123000	6.44e-01
Nicotinate metabolism	22	3.18e-01	0.123000	4.87e-01
Disease	1215	2.38e-12	-0.123000	2.48e-11
Cellular Senescence	106	2.97e-02	0.122000	8.11e-02
Cell surface interactions at the vascular wall	74	6.93e-02	-0.122000	1.61e-01
Association of TriC/CCT with target proteins during biosynthesis	31	2.40e-01	-0.122000	4.11e-01
RUNX2 regulates bone development	16	4.03e-01	0.121000	5.69e-01
Mitochondrial tRNA aminoacylation	15	4.18e-01	-0.121000	5.86e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	11	4.88e-01	-0.121000	6.36e-01
Processive synthesis on the lagging strand	13	4.52e-01	-0.121000	6.09e-01
RHO GTPases Activate ROCKs	17	3.91e-01	-0.120000	5.59e-01
Sensory processing of sound by inner hair cells of the cochlea	28	2.72e-01	-0.120000	4.45e-01
Transcriptional activation of mitochondrial biogenesis	47	1.56e-01	0.120000	2.97e-01
Removal of the Flap Intermediate from the C-strand	14	4.40e-01	-0.119000	6.03e-01
Meiosis	34	2.30e-01	0.119000	4.00e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	37	2.12e-01	0.119000	3.77e-01
FLT3 Signaling	32	2.46e-01	0.119000	4.18e-01
RNA Polymerase III Abortive And Retractive Initiation	37	2.14e-01	-0.118000	3.79e-01
RNA Polymerase III Transcription	37	2.14e-01	-0.118000	3.79e-01
Regulation of signaling by CBL	20	3.61e-01	0.118000	5.29e-01
Immune System	1374	1.28e-12	-0.118000	1.36e-11
Other interleukin signaling	16	4.17e-01	-0.117000	5.85e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	20	3.66e-01	-0.117000	5.35e-01
Meiotic synapsis	19	3.80e-01	0.117000	5.46e-01
RNA Polymerase I Transcription Initiation	39	2.10e-01	-0.116000	3.76e-01
Sialic acid metabolism	23	3.36e-01	0.116000	5.05e-01
Amino acid transport across the plasma membrane	18	3.95e-01	0.116000	5.63e-01
EPHA-mediated growth cone collapse	11	5.06e-01	-0.116000	6.50e-01
Clathrin-mediated endocytosis	106	4.05e-02	-0.115000	1.05e-01
DAG and IP3 signaling	28	2.91e-01	0.115000	4.62e-01
Cleavage of the damaged pyrimidine	13	4.72e-01	-0.115000	6.28e-01
Depyrimidination	13	4.72e-01	-0.115000	6.28e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	13	4.72e-01	-0.115000	6.28e-01
TP53 Regulates Transcription of DNA Repair Genes	60	1.23e-01	-0.115000	2.53e-01
HCMV Infection	88	6.24e-02	-0.115000	1.47e-01
Transcriptional regulation by small RNAs	47	1.73e-01	-0.115000	3.21e-01
E2F mediated regulation of DNA replication	18	4.00e-01	0.115000	5.66e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes	16	4.30e-01	-0.114000	5.96e-01
RIP-mediated NFkB activation via ZBP1	15	4.45e-01	-0.114000	6.03e-01
Cytokine Signaling in Immune system	533	9.14e-06	-0.114000	6.06e-05
p75 NTR receptor-mediated signalling	73	9.36e-02	0.114000	2.05e-01
Chondroitin sulfate/dermatan sulfate metabolism	28	3.00e-01	0.113000	4.70e-01
STAT3 nuclear events downstream of ALK signaling	10	5.36e-01	0.113000	6.77e-01
Reproduction	45	1.91e-01	0.113000	3.49e-01
Negative regulation of FGFR1 signaling	19	3.96e-01	-0.113000	5.64e-01
Class A/1 (Rhodopsin-like receptors)	55	1.52e-01	-0.112000	2.90e-01
Signaling by SCF-KIT	33	2.67e-01	0.112000	4.39e-01
RHOBTB2 GTPase cycle	23	3.54e-01	-0.112000	5.21e-01
TGF-beta receptor signaling activates SMADs	35	2.54e-01	-0.112000	4.24e-01
Deubiquitination	205	6.11e-03	-0.112000	2.23e-02
Fanconi Anemia Pathway	27	3.17e-01	-0.111000	4.86e-01
Presynaptic phase of homologous DNA pairing and strand exchange	32	2.79e-01	0.111000	4.52e-01
RAC3 GTPase cycle	69	1.13e-01	0.111000	2.37e-01
Antiviral mechanism by IFN-stimulated genes	129	3.08e-02	-0.110000	8.37e-02
Disorders of Developmental Biology	11	5.27e-01	0.110000	6.68e-01
Disorders of Nervous System Development	11	5.27e-01	0.110000	6.68e-01
Loss of function of MECP2 in Rett syndrome	11	5.27e-01	0.110000	6.68e-01
Pervasive developmental disorders	11	5.27e-01	0.110000	6.68e-01
DNA strand elongation	20	3.96e-01	-0.110000	5.64e-01
Semaphorin interactions	46	1.99e-01	-0.110000	3.59e-01
RNA Polymerase I Promoter Clearance	43	2.14e-01	-0.110000	3.79e-01
RNA Polymerase I Transcription	43	2.14e-01	-0.110000	3.79e-01
Keratan sulfate biosynthesis	14	4.78e-01	0.110000	6.30e-01
Bacterial Infection Pathways	53	1.69e-01	-0.109000	3.16e-01
CD209 (DC-SIGN) signaling	17	4.36e-01	0.109000	6.01e-01
N-glycan antennae elongation in the medial/trans-Golgi	16	4.52e-01	0.109000	6.09e-01
Oncogene Induced Senescence	26	3.38e-01	0.109000	5.06e-01
ATF6 (ATF6-alpha) activates chaperones	12	5.15e-01	-0.109000	6.58e-01
Signaling by Retinoic Acid	25	3.48e-01	-0.109000	5.16e-01
Glycolysis	59	1.50e-01	-0.108000	2.88e-01
Phosphorylation of CD3 and TCR zeta chains	14	4.85e-01	-0.108000	6.36e-01
Glycerophospholipid biosynthesis	80	9.76e-02	0.107000	2.12e-01
O-linked glycosylation	36	2.67e-01	0.107000	4.39e-01
Meiotic recombination	17	4.47e-01	0.107000	6.05e-01
Peptide ligand-binding receptors	32	2.97e-01	-0.107000	4.69e-01
SUMOylation of DNA damage response and repair proteins	73	1.16e-01	0.106000	2.41e-01
Signaling by ERBB4	33	2.90e-01	-0.106000	4.62e-01
Sensory processing of sound by outer hair cells of the cochlea	23	3.77e-01	-0.106000	5.44e-01
Role of phospholipids in phagocytosis	18	4.35e-01	0.106000	6.01e-01
Transport of small molecules	395	3.41e-04	-0.106000	1.78e-03
Regulation of pyruvate dehydrogenase (PDH) complex	14	4.93e-01	-0.106000	6.40e-01
Formation of apoptosome	10	5.64e-01	0.106000	7.00e-01
Regulation of the apoptosome activity	10	5.64e-01	0.106000	7.00e-01
AKT phosphorylates targets in the cytosol	14	4.95e-01	0.105000	6.41e-01
Nuclear signaling by ERBB4	18	4.39e-01	-0.105000	6.03e-01
Signalling to RAS	14	4.95e-01	-0.105000	6.41e-01
RAF-independent MAPK1/3 activation	18	4.40e-01	0.105000	6.03e-01
trans-Golgi Network Vesicle Budding	67	1.38e-01	-0.105000	2.75e-01
RHOH GTPase cycle	28	3.37e-01	0.105000	5.06e-01
RHOD GTPase cycle	39	2.59e-01	0.104000	4.28e-01
Laminin interactions	10	5.68e-01	0.104000	7.02e-01
Budding and maturation of HIV virion	31	3.16e-01	-0.104000	4.86e-01
Factors involved in megakaryocyte development and platelet production	91	8.75e-02	0.104000	1.95e-01
RHO GTPases Activate Formins	96	8.03e-02	-0.104000	1.82e-01
Polymerase switching on the C-strand of the telomere	21	4.12e-01	-0.103000	5.81e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	4.74e-01	-0.103000	6.28e-01
Energy dependent regulation of mTOR by LKB1-AMPK	27	3.53e-01	-0.103000	5.21e-01
Death Receptor Signaling	123	4.97e-02	0.103000	1.23e-01
Transcription of E2F targets under negative control by DREAM complex	12	5.40e-01	0.102000	6.79e-01
Glycogen metabolism	19	4.43e-01	-0.102000	6.03e-01
Regulation of NF-kappa B signaling	18	4.56e-01	-0.101000	6.13e-01
Regulation of KIT signaling	12	5.44e-01	0.101000	6.83e-01
Intraflagellar transport	38	2.82e-01	-0.101000	4.55e-01
Regulation of actin dynamics for phagocytic cup formation	56	1.92e-01	-0.101000	3.50e-01
G-protein mediated events	36	2.96e-01	0.101000	4.67e-01
Adaptive Immune System	566	5.30e-05	-0.101000	3.13e-04
CRMPs in Sema3A signaling	11	5.65e-01	-0.100000	7.00e-01
Activation of BH3-only proteins	27	3.68e-01	-0.100000	5.36e-01
Processive synthesis on the C-strand of the telomere	16	4.89e-01	-0.099900	6.37e-01
Metabolism of carbohydrates	194	1.73e-02	-0.099600	5.32e-02
Activation of gene expression by SREBF (SREBP)	41	2.71e-01	-0.099500	4.44e-01
Zinc transporters	10	5.88e-01	-0.098900	7.23e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	11	5.71e-01	0.098700	7.03e-01
Signaling by RAF1 mutants	33	3.29e-01	-0.098300	4.97e-01
Synthesis of substrates in N-glycan biosythesis	50	2.33e-01	-0.097600	4.02e-01
Adrenaline,noradrenaline inhibits insulin secretion	12	5.61e-01	-0.097000	6.99e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	47	2.50e-01	0.097000	4.20e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	47	2.50e-01	0.097000	4.20e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	47	2.50e-01	0.097000	4.20e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	47	2.50e-01	0.097000	4.20e-01
Signaling by NOTCH1 in Cancer	47	2.50e-01	0.097000	4.20e-01
Extracellular matrix organization	106	8.79e-02	-0.096200	1.95e-01
Cargo trafficking to the periciliary membrane	39	2.99e-01	0.096100	4.70e-01
RHO GTPase Effectors	193	2.20e-02	-0.096000	6.42e-02
Class B/2 (Secretin family receptors)	20	4.59e-01	0.095800	6.15e-01
Golgi Cisternae Pericentriolar Stack Reorganization	12	5.66e-01	-0.095700	7.01e-01
VEGFA-VEGFR2 Pathway	81	1.39e-01	0.095200	2.77e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	28	3.84e-01	-0.095100	5.51e-01
Inwardly rectifying K+ channels	12	5.69e-01	-0.095000	7.02e-01
Nonhomologous End-Joining (NHEJ)	30	3.70e-01	0.094600	5.38e-01
Platelet sensitization by LDL	14	5.40e-01	0.094600	6.79e-01
Uptake and function of anthrax toxins	10	6.06e-01	0.094200	7.38e-01
Activation of the pre-replicative complex	19	4.79e-01	-0.093900	6.31e-01
Cardiac conduction	42	2.93e-01	0.093900	4.63e-01
Interferon Signaling	209	2.00e-02	-0.093800	5.96e-02
O-linked glycosylation of mucins	26	4.08e-01	0.093800	5.75e-01
Cell Cycle	474	5.56e-04	-0.093600	2.80e-03
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	5.32e-01	-0.093200	6.72e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	29	3.85e-01	0.093200	5.52e-01
HS-GAG degradation	14	5.46e-01	-0.093200	6.85e-01
Signaling by WNT	179	3.33e-02	-0.092600	8.94e-02
Interferon alpha/beta signaling	56	2.32e-01	-0.092500	4.01e-01
Cell Cycle, Mitotic	386	2.19e-03	-0.091600	9.55e-03
ATF4 activates genes in response to endoplasmic reticulum stress	23	4.48e-01	-0.091500	6.06e-01
Homologous DNA Pairing and Strand Exchange	34	3.56e-01	0.091500	5.24e-01
TAK1-dependent IKK and NF-kappa-B activation	39	3.25e-01	-0.091100	4.95e-01
Synthesis of bile acids and bile salts	17	5.16e-01	0.091000	6.59e-01
Regulation of IFNA/IFNB signaling	12	5.85e-01	0.091000	7.20e-01
Anchoring of the basal body to the plasma membrane	82	1.58e-01	0.090400	3.00e-01
Cellular response to heat stress	84	1.55e-01	-0.089900	2.96e-01
Metabolism of vitamins and cofactors	124	8.65e-02	-0.089400	1.93e-01
Diseases of programmed cell death	40	3.29e-01	-0.089300	4.97e-01
Glycogen breakdown (glycogenolysis)	11	6.09e-01	0.089100	7.41e-01
Transport of bile salts and organic acids, metal ions and amine compounds	34	3.70e-01	0.089000	5.38e-01
Signaling by ERBB2	35	3.63e-01	-0.089000	5.31e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	5.40e-01	-0.088400	6.79e-01
Signaling by ALK	20	4.95e-01	0.088200	6.41e-01
Regulation of HSF1-mediated heat shock response	69	2.07e-01	-0.088000	3.71e-01
Interleukin-4 and Interleukin-13 signaling	60	2.42e-01	-0.087500	4.12e-01
Transcriptional Regulation by TP53	317	8.61e-03	-0.086400	2.96e-02
RUNX3 regulates p14-ARF	10	6.36e-01	0.086400	7.61e-01
GPCR downstream signalling	211	3.29e-02	0.085600	8.85e-02
Vitamin B5 (pantothenate) metabolism	13	5.94e-01	-0.085500	7.27e-01
Interferon gamma signaling	72	2.11e-01	-0.085400	3.76e-01
Signaling by Insulin receptor	48	3.07e-01	-0.085400	4.78e-01
Signaling by GPCR	226	2.79e-02	0.085300	7.69e-02
GPVI-mediated activation cascade	27	4.44e-01	0.085200	6.03e-01
MET promotes cell motility	18	5.32e-01	0.085100	6.72e-01
Regulation of lipid metabolism by PPARalpha	98	1.47e-01	0.085000	2.87e-01
Regulation of insulin secretion	37	3.78e-01	0.083900	5.44e-01
Signaling by Non-Receptor Tyrosine Kinases	38	3.73e-01	-0.083600	5.39e-01
Signaling by PTK6	38	3.73e-01	-0.083600	5.39e-01
Cytochrome P450 - arranged by substrate type	18	5.39e-01	-0.083600	6.79e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	4.15e-01	-0.083300	5.83e-01
Rab regulation of trafficking	113	1.27e-01	0.083200	2.60e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	480	2.09e-03	0.082900	9.26e-03
RUNX2 regulates osteoblast differentiation	12	6.23e-01	0.081900	7.52e-01
Stimuli-sensing channels	44	3.50e-01	0.081500	5.18e-01
RHOG GTPase cycle	58	2.84e-01	0.081500	4.56e-01
Opioid Signalling	61	2.72e-01	0.081400	4.45e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	17	5.62e-01	0.081200	6.99e-01
Trafficking of AMPA receptors	17	5.62e-01	0.081200	6.99e-01
VEGFR2 mediated vascular permeability	23	5.02e-01	0.081000	6.46e-01
SUMOylation of DNA methylation proteins	13	6.17e-01	0.080100	7.47e-01
Signaling by Rho GTPases	467	3.40e-03	0.080000	1.40e-02
Lagging Strand Synthesis	17	5.68e-01	-0.080000	7.02e-01
PPARA activates gene expression	96	1.78e-01	0.079800	3.28e-01
HCMV Late Events	53	3.16e-01	-0.079800	4.86e-01
Telomere C-strand (Lagging Strand) Synthesis	27	4.74e-01	-0.079600	6.28e-01
Transcriptional regulation by RUNX1	143	1.02e-01	-0.079500	2.19e-01
Biotin transport and metabolism	11	6.52e-01	0.078600	7.76e-01
Kinesins	28	4.72e-01	-0.078600	6.28e-01
STING mediated induction of host immune responses	12	6.38e-01	-0.078500	7.62e-01
Extra-nuclear estrogen signaling	50	3.38e-01	-0.078400	5.06e-01
Downstream signal transduction	25	5.02e-01	0.077700	6.46e-01
Regulation of TNFR1 signaling	44	3.77e-01	-0.077100	5.44e-01
Golgi Associated Vesicle Biogenesis	52	3.40e-01	-0.076600	5.08e-01
FCGR3A-mediated IL10 synthesis	27	4.94e-01	0.076100	6.41e-01
Apoptotic execution phase	34	4.44e-01	0.075900	6.03e-01
Negative regulation of MAPK pathway	37	4.27e-01	-0.075500	5.94e-01
Hemostasis	348	1.68e-02	-0.075200	5.20e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	51	3.53e-01	-0.075200	5.21e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE	17	5.92e-01	-0.075100	7.26e-01
DNA Repair	241	4.59e-02	-0.075100	1.16e-01
Post-translational protein modification	985	1.02e-04	-0.074900	5.67e-04
Deadenylation-dependent mRNA decay	49	3.66e-01	-0.074700	5.35e-01
Attachment and Entry 9694614	11	6.69e-01	-0.074600	7.90e-01
Protein-protein interactions at synapses	33	4.62e-01	0.074000	6.18e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	10	6.87e-01	0.073500	8.01e-01
Signaling by MET	51	3.64e-01	0.073500	5.33e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	33	4.74e-01	0.072100	6.28e-01
Diseases of DNA Double-Strand Break Repair	33	4.74e-01	0.072100	6.28e-01
Integrin signaling	22	5.64e-01	-0.071100	7.00e-01
The phototransduction cascade	18	6.02e-01	0.071100	7.34e-01
HCMV Early Events	65	3.28e-01	-0.070200	4.97e-01
Listeria monocytogenes entry into host cells	17	6.17e-01	-0.070200	7.47e-01
SUMOylation of chromatin organization proteins	53	3.78e-01	0.070100	5.44e-01
Purine salvage	12	6.74e-01	-0.070100	7.94e-01
Caspase-mediated cleavage of cytoskeletal proteins	10	7.02e-01	-0.070000	8.08e-01
RAC2 GTPase cycle	71	3.09e-01	0.070000	4.80e-01
Inactivation, recovery and regulation of the phototransduction cascade	17	6.20e-01	0.069400	7.50e-01
ZBP1(DAI) mediated induction of type I IFNs	18	6.11e-01	-0.069300	7.42e-01
G beta:gamma signalling through PLC beta	12	6.78e-01	-0.069300	7.94e-01
Presynaptic function of Kainate receptors	12	6.78e-01	-0.069300	7.94e-01
Tie2 Signaling	13	6.70e-01	0.068200	7.91e-01
Post NMDA receptor activation events	47	4.19e-01	-0.068200	5.86e-01
Nuclear Events (kinase and transcription factor activation)	45	4.31e-01	0.068000	5.97e-01
Signaling by PDGF	35	4.91e-01	0.067400	6.38e-01
HDR through Single Strand Annealing (SSA)	30	5.25e-01	0.067100	6.68e-01
DAP12 interactions	30	5.25e-01	-0.067100	6.68e-01
Erythropoietin activates RAS	13	6.76e-01	0.067000	7.94e-01
Bile acid and bile salt metabolism	18	6.23e-01	0.066900	7.52e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	29	5.37e-01	-0.066200	6.78e-01
CD28 co-stimulation	27	5.52e-01	0.066200	6.90e-01
Activation of HOX genes during differentiation	45	4.45e-01	-0.065900	6.03e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	45	4.45e-01	-0.065900	6.03e-01
Alpha-protein kinase 1 signaling pathway	11	7.08e-01	-0.065300	8.14e-01
Degradation of the extracellular matrix	51	4.21e-01	-0.065300	5.87e-01
Neurexins and neuroligins	22	5.97e-01	0.065200	7.30e-01
Recruitment of NuMA to mitotic centrosomes	74	3.36e-01	-0.064800	5.05e-01
Glucagon-type ligand receptors	11	7.12e-01	-0.064300	8.17e-01
Prostacyclin signalling through prostacyclin receptor	11	7.12e-01	-0.064300	8.17e-01
Toll Like Receptor 9 (TLR9) Cascade	95	2.84e-01	0.063800	4.56e-01
Caspase activation via Death Receptors in the presence of ligand	14	6.82e-01	0.063200	7.96e-01
TNFR1-induced proapoptotic signaling	23	6.00e-01	0.063200	7.33e-01
Signaling by ALK fusions and activated point mutants	50	4.41e-01	0.063000	6.03e-01
Signaling by ALK in cancer	50	4.41e-01	0.063000	6.03e-01
NOD1/2 Signaling Pathway	33	5.31e-01	-0.063000	6.72e-01
NS1 Mediated Effects on Host Pathways	39	4.97e-01	0.062900	6.42e-01
Signaling by BRAF and RAF1 fusions	54	4.28e-01	0.062500	5.94e-01
Plasma lipoprotein remodeling	13	6.97e-01	-0.062400	8.06e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	10	7.35e-01	0.061900	8.29e-01
Vpr-mediated nuclear import of PICs	35	5.27e-01	0.061800	6.68e-01
SARS-CoV-2 modulates autophagy	11	7.26e-01	0.061100	8.26e-01
Cell-Cell communication	74	3.68e-01	0.060700	5.36e-01
tRNA processing	111	2.73e-01	-0.060300	4.46e-01
Neurotransmitter release cycle	21	6.33e-01	0.060300	7.59e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	22	6.25e-01	0.060300	7.53e-01
Class I MHC mediated antigen processing & presentation	321	6.72e-02	-0.059900	1.58e-01
Leishmania infection	120	2.59e-01	-0.059800	4.28e-01
Parasitic Infection Pathways	120	2.59e-01	-0.059800	4.28e-01
Cilium Assembly	153	2.10e-01	0.058900	3.76e-01
Condensation of Prophase Chromosomes	10	7.47e-01	0.058900	8.35e-01
MyD88 cascade initiated on plasma membrane	86	3.48e-01	0.058700	5.16e-01
Toll Like Receptor 10 (TLR10) Cascade	86	3.48e-01	0.058700	5.16e-01
Toll Like Receptor 5 (TLR5) Cascade	86	3.48e-01	0.058700	5.16e-01
RAB geranylgeranylation	47	4.87e-01	-0.058600	6.36e-01
Activation of kainate receptors upon glutamate binding	15	6.95e-01	-0.058500	8.06e-01
Diseases associated with O-glycosylation of proteins	15	6.98e-01	0.057900	8.06e-01
Interactions of Rev with host cellular proteins	35	5.56e-01	-0.057500	6.94e-01
Glycosaminoglycan metabolism	68	4.14e-01	0.057400	5.82e-01
Generic Transcription Pathway	858	5.35e-03	0.057200	2.00e-02
Intrinsic Pathway for Apoptosis	50	4.87e-01	-0.056800	6.36e-01
PIP3 activates AKT signaling	198	1.72e-01	-0.056500	3.20e-01
GPCR ligand binding	75	3.98e-01	-0.056500	5.65e-01
Sema4D in semaphorin signaling	18	6.79e-01	-0.056400	7.94e-01
MAP kinase activation	59	4.59e-01	0.055800	6.15e-01
Epigenetic regulation of gene expression	115	3.04e-01	0.055600	4.75e-01
Transport of the SLBP Dependant Mature mRNA	35	5.71e-01	-0.055300	7.03e-01
PKA activation	12	7.40e-01	0.055300	8.32e-01
Depolymerization of the Nuclear Lamina	12	7.40e-01	0.055300	8.32e-01
Gene Silencing by RNA	67	4.36e-01	-0.055100	6.01e-01
Ion channel transport	89	3.71e-01	-0.055000	5.39e-01
SLC-mediated transmembrane transport	112	3.17e-01	0.054900	4.86e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	4.87e-01	-0.054800	6.36e-01
Postmitotic nuclear pore complex (NPC) reformation	25	6.38e-01	-0.054400	7.62e-01
Signal Transduction	1459	9.09e-04	0.053900	4.36e-03
Interleukin-17 signaling	61	4.69e-01	0.053700	6.26e-01
Signaling by VEGF	86	4.02e-01	0.052400	5.69e-01
TNFR1-induced NF-kappa-B signaling pathway	31	6.15e-01	-0.052300	7.46e-01
RNA polymerase II transcribes snRNA genes	68	4.57e-01	-0.052200	6.14e-01
Fcgamma receptor (FCGR) dependent phagocytosis	75	4.38e-01	-0.051900	6.03e-01
Activation of NMDA receptors and postsynaptic events	54	5.10e-01	-0.051900	6.54e-01
Impaired BRCA2 binding to RAD51	28	6.36e-01	0.051700	7.61e-01
Retinoid metabolism and transport	19	7.00e-01	-0.051100	8.08e-01
Signaling by FGFR3	25	6.59e-01	-0.051000	7.83e-01
Signaling by FGFR4	25	6.59e-01	-0.051000	7.83e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	7.26e-01	-0.050700	8.26e-01
MyD88-independent TLR4 cascade	100	3.84e-01	0.050500	5.51e-01
TRIF(TICAM1)-mediated TLR4 signaling	100	3.84e-01	0.050500	5.51e-01
Regulation of PTEN gene transcription	54	5.26e-01	0.050000	6.68e-01
Metabolism of folate and pterines	15	7.39e-01	-0.049700	8.32e-01
Processing of DNA double-strand break ends	51	5.47e-01	-0.048800	6.86e-01
Toll Like Receptor 3 (TLR3) Cascade	95	4.19e-01	0.048100	5.86e-01
Neurotransmitter receptors and postsynaptic signal transmission	87	4.40e-01	-0.048000	6.03e-01
Signalling to ERKs	27	6.67e-01	0.047900	7.90e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	90	4.35e-01	0.047700	6.01e-01
RHOBTB1 GTPase cycle	23	6.95e-01	0.047200	8.06e-01
Sensory Perception	77	4.75e-01	-0.047200	6.28e-01
TNFs bind their physiological receptors	11	7.88e-01	-0.046800	8.62e-01
Leading Strand Synthesis	13	7.71e-01	-0.046700	8.49e-01
Polymerase switching	13	7.71e-01	-0.046700	8.49e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	13	7.72e-01	-0.046500	8.49e-01
ECM proteoglycans	18	7.34e-01	0.046300	8.29e-01
Transcriptional regulation of white adipocyte differentiation	68	5.12e-01	0.046100	6.55e-01
CaM pathway	24	6.97e-01	0.045900	8.06e-01
Calmodulin induced events	24	6.97e-01	0.045900	8.06e-01
Inactivation of CSF3 (G-CSF) signaling	24	6.99e-01	-0.045700	8.07e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	46	5.94e-01	0.045500	7.27e-01
Signal amplification	21	7.20e-01	-0.045300	8.22e-01
SUMOylation of DNA replication proteins	39	6.29e-01	-0.044800	7.55e-01
Transport of Ribonucleoproteins into the Host Nucleus	31	6.68e-01	0.044600	7.90e-01
Deactivation of the beta-catenin transactivating complex	30	6.73e-01	-0.044500	7.94e-01
G2/M DNA damage checkpoint	49	5.91e-01	-0.044500	7.25e-01
EML4 and NUDC in mitotic spindle formation	77	5.06e-01	-0.043900	6.50e-01
G1/S-Specific Transcription	15	7.71e-01	0.043500	8.49e-01
BBSome-mediated cargo-targeting to cilium	18	7.50e-01	-0.043400	8.35e-01
TRAF6 mediated NF-kB activation	20	7.39e-01	0.043000	8.32e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	7.67e-01	-0.042800	8.49e-01
G-protein activation	14	7.82e-01	-0.042700	8.59e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	92	4.80e-01	0.042700	6.32e-01
Regulation of TP53 Expression and Degradation	34	6.67e-01	0.042600	7.90e-01
Gene expression (Transcription)	1109	2.00e-02	0.042500	5.96e-02
EGR2 and SOX10-mediated initiation of Schwann cell myelination	14	7.85e-01	-0.042200	8.60e-01
Apoptotic factor-mediated response	19	7.52e-01	-0.041900	8.35e-01
Ca-dependent events	26	7.12e-01	0.041800	8.17e-01
Metabolism of water-soluble vitamins and cofactors	87	5.02e-01	-0.041700	6.47e-01
Oncogenic MAPK signaling	68	5.54e-01	0.041600	6.92e-01
Nuclear Envelope Breakdown	48	6.23e-01	0.041100	7.52e-01
Signaling by PDGFRA extracellular domain mutants	12	8.06e-01	0.040900	8.75e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	8.06e-01	0.040900	8.75e-01
Signaling by NTRKs	97	4.87e-01	0.040900	6.36e-01
Metabolism of fat-soluble vitamins	22	7.43e-01	-0.040400	8.33e-01
Activation of ATR in response to replication stress	21	7.49e-01	-0.040300	8.35e-01
ISG15 antiviral mechanism	70	5.62e-01	-0.040200	6.99e-01
MyD88 dependent cascade initiated on endosome	91	5.10e-01	0.040100	6.54e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	48	6.34e-01	0.039700	7.60e-01
RNA Polymerase II Transcription	971	4.27e-02	0.039300	1.10e-01
Intracellular signaling by second messengers	225	3.16e-01	-0.039000	4.86e-01
Transcriptional Regulation by VENTX	34	6.95e-01	0.038900	8.06e-01
Signaling by NOTCH2	24	7.42e-01	-0.038900	8.32e-01
Ribavirin ADME	10	8.33e-01	-0.038600	8.94e-01
G alpha (q) signalling events	74	5.67e-01	0.038600	7.01e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	19	7.77e-01	0.037600	8.54e-01
Vesicle-mediated transport	517	1.49e-01	-0.037600	2.88e-01
Early Phase of HIV Life Cycle	17	7.89e-01	0.037400	8.62e-01
RHOBTB GTPase Cycle	35	7.04e-01	-0.037200	8.10e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	29	7.30e-01	0.037000	8.29e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	29	7.30e-01	0.037000	8.29e-01
Formation of the cornified envelope	14	8.12e-01	0.036700	8.80e-01
Keratinization	14	8.12e-01	0.036700	8.80e-01
Integration of energy metabolism	59	6.27e-01	0.036700	7.54e-01
Toll Like Receptor 4 (TLR4) Cascade	126	4.82e-01	0.036300	6.34e-01
Signaling by ERBB2 in Cancer	14	8.14e-01	0.036300	8.81e-01
Telomere C-strand synthesis initiation	12	8.29e-01	-0.036000	8.94e-01
Cell junction organization	49	6.67e-01	0.035600	7.90e-01
Platelet homeostasis	46	6.77e-01	-0.035500	7.94e-01
Platelet Aggregation (Plug Formation)	23	7.69e-01	-0.035400	8.49e-01
Maturation of spike protein 9694548	34	7.21e-01	-0.035400	8.23e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	160	4.42e-01	-0.035400	6.03e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	17	8.01e-01	-0.035300	8.74e-01
SUMOylation of RNA binding proteins	44	6.88e-01	0.035000	8.01e-01
Regulation of TP53 Activity	135	4.84e-01	0.035000	6.35e-01
Mitotic Prophase	76	5.99e-01	0.034900	7.32e-01
Regulation of TP53 Activity through Acetylation	29	7.51e-01	0.034100	8.35e-01
Nuclear Pore Complex (NPC) Disassembly	34	7.33e-01	0.033800	8.29e-01
Diseases of mitotic cell cycle	31	7.45e-01	-0.033700	8.35e-01
Transport of the SLBP independent Mature mRNA	34	7.35e-01	-0.033600	8.29e-01
TP53 Regulates Transcription of Cell Death Genes	37	7.28e-01	0.033100	8.28e-01
FCGR3A-mediated phagocytosis	53	6.79e-01	-0.032900	7.94e-01
Leishmania phagocytosis	53	6.79e-01	-0.032900	7.94e-01
Parasite infection	53	6.79e-01	-0.032900	7.94e-01
Muscle contraction	72	6.33e-01	-0.032600	7.59e-01
Nuclear import of Rev protein	32	7.50e-01	-0.032500	8.35e-01
SHC1 events in ERBB2 signaling	11	8.52e-01	-0.032500	9.07e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	38	7.30e-01	0.032400	8.29e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	14	8.35e-01	-0.032200	8.94e-01
Ovarian tumor domain proteases	32	7.55e-01	0.031900	8.37e-01
Mitochondrial RNA degradation	23	7.92e-01	0.031800	8.65e-01
Platelet calcium homeostasis	15	8.32e-01	-0.031700	8.94e-01
SUMOylation of SUMOylation proteins	34	7.51e-01	-0.031500	8.35e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	75	6.45e-01	-0.030800	7.70e-01
Diseases associated with glycosaminoglycan metabolism	18	8.21e-01	0.030700	8.88e-01
Signaling by EGFR	36	7.51e-01	-0.030600	8.35e-01
Molecules associated with elastic fibres	11	8.62e-01	0.030300	9.13e-01
RAF activation	32	7.74e-01	-0.029400	8.51e-01
SUMOylation of ubiquitinylation proteins	38	7.60e-01	0.028600	8.42e-01
Translation of Structural Proteins 9694635	54	7.20e-01	-0.028200	8.22e-01
Deposition of new CENPA-containing nucleosomes at the centromere	19	8.33e-01	-0.028000	8.94e-01
Nucleosome assembly	19	8.33e-01	-0.028000	8.94e-01
Signaling by NOTCH3	33	7.86e-01	-0.027400	8.60e-01
Sema4D induced cell migration and growth-cone collapse	15	8.55e-01	-0.027400	9.09e-01
Membrane Trafficking	499	3.04e-01	-0.027200	4.75e-01
Mitotic Spindle Checkpoint	79	6.78e-01	-0.027100	7.94e-01
Homology Directed Repair	79	6.80e-01	-0.026900	7.95e-01
Cyclin A/B1/B2 associated events during G2/M transition	17	8.50e-01	0.026500	9.06e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	42	7.69e-01	-0.026200	8.49e-01
VEGFR2 mediated cell proliferation	15	8.61e-01	0.026000	9.13e-01
Loss of Nlp from mitotic centrosomes	59	7.34e-01	0.025600	8.29e-01
Loss of proteins required for interphase microtubule organization from the centrosome	59	7.34e-01	0.025600	8.29e-01
Negative regulation of MET activity	16	8.60e-01	-0.025600	9.13e-01
ESR-mediated signaling	124	6.27e-01	-0.025400	7.54e-01
Neuronal System	141	6.04e-01	-0.025400	7.36e-01
Signaling by NTRK1 (TRKA)	85	6.88e-01	0.025200	8.01e-01
Transport of vitamins, nucleosides, and related molecules	25	8.28e-01	-0.025100	8.94e-01
Glucagon signaling in metabolic regulation	19	8.51e-01	-0.024900	9.07e-01
Rev-mediated nuclear export of HIV RNA	33	8.05e-01	-0.024900	8.75e-01
Metal ion SLC transporters	16	8.64e-01	-0.024700	9.13e-01
Transmission across Chemical Synapses	108	6.59e-01	-0.024600	7.83e-01
Toll-like Receptor Cascades	143	6.17e-01	0.024300	7.47e-01
Antigen processing: Ubiquitination & Proteasome degradation	255	5.12e-01	-0.024000	6.55e-01
p130Cas linkage to MAPK signaling for integrins	11	8.92e-01	0.023500	9.36e-01
AURKA Activation by TPX2	60	7.55e-01	0.023300	8.37e-01
G alpha (z) signalling events	25	8.42e-01	-0.023100	9.00e-01
HDR through Homologous Recombination (HRR)	51	7.85e-01	-0.022100	8.60e-01
NGF-stimulated transcription	25	8.49e-01	-0.022000	9.06e-01
Signaling by TGFB family members	82	7.32e-01	0.021900	8.29e-01
Heparan sulfate/heparin (HS-GAG) metabolism	28	8.41e-01	-0.021900	9.00e-01
Processing of Intronless Pre-mRNAs	20	8.66e-01	0.021800	9.13e-01
Signaling by TGF-beta Receptor Complex	73	7.48e-01	-0.021800	8.35e-01
Regulation of TP53 Activity through Phosphorylation	73	7.48e-01	-0.021800	8.35e-01
A tetrasaccharide linker sequence is required for GAG synthesis	12	8.99e-01	-0.021200	9.38e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	100	7.15e-01	0.021200	8.18e-01
Toll Like Receptor 2 (TLR2) Cascade	100	7.15e-01	0.021200	8.18e-01
Toll Like Receptor TLR1:TLR2 Cascade	100	7.15e-01	0.021200	8.18e-01
Toll Like Receptor TLR6:TLR2 Cascade	100	7.15e-01	0.021200	8.18e-01
Peptide hormone metabolism	35	8.30e-01	0.021000	8.94e-01
Constitutive Signaling by EGFRvIII	12	9.06e-01	-0.019700	9.41e-01
Signaling by EGFRvIII in Cancer	12	9.06e-01	-0.019700	9.41e-01
Thromboxane signalling through TP receptor	15	8.95e-01	0.019600	9.37e-01
Ion homeostasis	27	8.62e-01	-0.019400	9.13e-01
SLC transporter disorders	56	8.05e-01	0.019100	8.75e-01
Diseases of DNA repair	41	8.34e-01	0.019000	8.94e-01
ADP signalling through P2Y purinoceptor 1	17	8.94e-01	-0.018700	9.37e-01
HATs acetylate histones	75	7.83e-01	0.018400	8.59e-01
Vasopressin regulates renal water homeostasis via Aquaporins	23	8.80e-01	0.018300	9.24e-01
Cytosolic sulfonation of small molecules	11	9.19e-01	0.017800	9.47e-01
Ras activation upon Ca2+ influx through NMDA receptor	11	9.20e-01	-0.017500	9.47e-01
Signaling by FGFR in disease	42	8.46e-01	0.017300	9.04e-01
Signaling by FGFR1	32	8.66e-01	-0.017200	9.13e-01
SUMOylation of transcription factors	14	9.11e-01	0.017200	9.43e-01
G-protein beta:gamma signalling	24	8.85e-01	-0.017100	9.28e-01
FCERI mediated MAPK activation	27	8.78e-01	0.017100	9.23e-01
Costimulation by the CD28 family	51	8.34e-01	-0.017000	8.94e-01
DNA Double Strand Break Response	39	8.64e-01	0.015900	9.13e-01
G beta:gamma signalling through PI3Kgamma	18	9.07e-01	0.015900	9.41e-01
Effects of PIP2 hydrolysis	18	9.08e-01	-0.015800	9.41e-01
Potential therapeutics for SARS	82	8.05e-01	-0.015800	8.75e-01
Regulation of TP53 Degradation	33	8.77e-01	0.015600	9.23e-01
Signaling by Receptor Tyrosine Kinases	333	6.50e-01	-0.014600	7.74e-01
Mitotic Prometaphase	151	7.60e-01	0.014500	8.42e-01
G alpha (i) signalling events	104	8.03e-01	-0.014200	8.75e-01
TBC/RABGAPs	44	8.75e-01	-0.013700	9.21e-01
TRP channels	12	9.36e-01	-0.013400	9.59e-01
Translation of Structural Proteins 9683701	29	9.02e-01	0.013200	9.40e-01
Late SARS-CoV-2 Infection Events	58	8.62e-01	0.013200	9.13e-01
Ion transport by P-type ATPases	29	9.03e-01	0.013000	9.40e-01
Interleukin-37 signaling	15	9.31e-01	-0.013000	9.57e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	99	8.27e-01	-0.012800	8.92e-01
Non-integrin membrane-ECM interactions	23	9.16e-01	0.012700	9.46e-01
Export of Viral Ribonucleoproteins from Nucleus	32	9.03e-01	-0.012400	9.40e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	64	8.67e-01	0.012100	9.13e-01
Amplification of signal from the kinetochores	64	8.67e-01	0.012100	9.13e-01
Signaling by CSF3 (G-CSF)	29	9.13e-01	-0.011700	9.45e-01
Negative regulators of DDX58/IFIH1 signaling	34	9.09e-01	0.011400	9.41e-01
Keratan sulfate/keratin metabolism	19	9.35e-01	-0.010900	9.59e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	9.47e-01	-0.010700	9.68e-01
Regulation of TP53 Activity through Methylation	19	9.36e-01	-0.010700	9.59e-01
Metabolism of lipids	491	6.91e-01	-0.010600	8.04e-01
Anti-inflammatory response favouring Leishmania parasite infection	48	8.99e-01	0.010600	9.38e-01
Leishmania parasite growth and survival	48	8.99e-01	0.010600	9.38e-01
Visual phototransduction	43	9.16e-01	0.009320	9.46e-01
Ephrin signaling	13	9.55e-01	0.009010	9.72e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	63	9.02e-01	-0.008950	9.40e-01
Organelle biogenesis and maintenance	235	8.16e-01	-0.008850	8.83e-01
Regulation of PLK1 Activity at G2/M Transition	75	8.96e-01	-0.008750	9.37e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	17	9.51e-01	0.008580	9.70e-01
Elastic fibre formation	14	9.56e-01	0.008510	9.72e-01
Other semaphorin interactions	12	9.63e-01	0.007840	9.76e-01
Aquaporin-mediated transport	24	9.49e-01	-0.007590	9.69e-01
Transport of Mature mRNA Derived from an Intronless Transcript	41	9.35e-01	-0.007400	9.59e-01
Cyclin D associated events in G1	38	9.37e-01	-0.007380	9.59e-01
G1 Phase	38	9.37e-01	-0.007380	9.59e-01
RMTs methylate histone arginines	30	9.46e-01	-0.007160	9.68e-01
Centrosome maturation	70	9.19e-01	-0.007030	9.47e-01
Recruitment of mitotic centrosome proteins and complexes	70	9.19e-01	-0.007030	9.47e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	9.71e-01	-0.006620	9.80e-01
Defects in vitamin and cofactor metabolism	17	9.64e-01	-0.006260	9.76e-01
Signaling by ERBB2 ECD mutants	12	9.71e-01	0.006160	9.80e-01
Thrombin signalling through proteinase activated receptors (PARs)	20	9.62e-01	0.006140	9.76e-01
DAP12 signaling	24	9.61e-01	-0.005830	9.76e-01
Diseases of signal transduction by growth factor receptors and second messengers	324	8.61e-01	-0.005720	9.13e-01
G alpha (s) signalling events	50	9.50e-01	-0.005130	9.69e-01
Pre-NOTCH Processing in Golgi	16	9.72e-01	0.005060	9.80e-01
Early SARS-CoV-2 Infection Events	29	9.63e-01	0.004980	9.76e-01
TNF signaling	52	9.55e-01	-0.004490	9.72e-01
Signaling by ERBB2 KD Mutants	13	9.83e-01	0.003410	9.88e-01
NEP/NS2 Interacts with the Cellular Export Machinery	31	9.75e-01	-0.003260	9.83e-01
ADORA2B mediated anti-inflammatory cytokines production	26	9.78e-01	0.003190	9.84e-01
Branched-chain amino acid catabolism	21	9.81e-01	-0.003040	9.87e-01
DNA Double-Strand Break Repair	104	9.59e-01	-0.002930	9.75e-01
Resolution of Sister Chromatid Cohesion	84	9.65e-01	-0.002790	9.76e-01
Assembly Of The HIV Virion	19	9.83e-01	-0.002780	9.88e-01
Interactions of Vpr with host cellular proteins	38	9.84e-01	-0.001910	9.88e-01
Signaling by Nuclear Receptors	174	9.71e-01	-0.001600	9.80e-01
Integration of provirus	11	9.93e-01	0.001480	9.95e-01
Sphingolipid metabolism	61	9.85e-01	-0.001440	9.88e-01
Regulation of IFNG signaling	13	9.94e-01	-0.001140	9.95e-01
Estrogen-dependent gene expression	77	9.88e-01	0.001010	9.90e-01
TP53 Regulates Transcription of Cell Cycle Genes	35	9.99e-01	0.000162	9.99e-01

---

Detailed Gene set reports

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	317
set	Eukaryotic Translation Termination
setSize	90
pANOVA	2.34e-39
s.dist	-0.799
p.adjustANOVA	3.04e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
TRMT112	-2848
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
RPS27L	-2611
RPL26L1	-2572
RPL29	-2433
RPL4	-2374
RPL27A	-2238
RPS13	-2162
RPS6	-2137
RPL15	-2045
RPL17	-1968
RPLP0	-1966
GSPT2	-1653
APEH	-1444
RPL22L1	-985
RPL5	-485
RPL12	-443
GSPT1	-159
RPS17	7
RPL31	20
RPL7	108
RPS2	319
ETF1	467
RPS4X	1068
RPL9	1356
RPS11	1556
RPL23	1657
RPL39L	3853
RPL13A	5851
RPS20	6819

---

Viral mRNA Translation

Viral mRNA Translation

	1259
set	Viral mRNA Translation
setSize	87
pANOVA	1.3e-37
s.dist	-0.794
p.adjustANOVA	9.97e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
RPS27L	-2611
RPL26L1	-2572
RPL29	-2433
RPL4	-2374
RPL27A	-2238
RPS13	-2162
RPS6	-2137
RPL15	-2045
RPL17	-1968
RPLP0	-1966
RPL22L1	-985
RPL5	-485
GRSF1	-475
RPL12	-443
RPS17	7
RPL31	20
RPL7	108
RPS2	319
RPS4X	1068
RPL9	1356
RPS11	1556
RPL23	1657
DNAJC3	3683
RPL39L	3853
RPL13A	5851
RPS20	6819

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	315
set	Eukaryotic Translation Elongation
setSize	90
pANOVA	7.27e-38
s.dist	-0.783
p.adjustANOVA	6.3e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
EEF1B2	-3090
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
EEF1D	-2810
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
RPS27L	-2611
RPL26L1	-2572
RPL29	-2433
RPL4	-2374
RPL27A	-2238
RPS13	-2162
RPS6	-2137
RPL15	-2045
RPL17	-1968
RPLP0	-1966
EEF1G	-1871
RPL22L1	-985
RPL5	-485
RPL12	-443
RPS17	7
RPL31	20
RPL7	108
RPS2	319
RPS4X	1068
RPL9	1356
RPS11	1556
RPL23	1657
EEF2	2708
RPL39L	3853
RPL13A	5851
RPS20	6819
EEF1A1	7185

---

Peptide chain elongation

Peptide chain elongation

	745
set	Peptide chain elongation
setSize	87
pANOVA	2.48e-36
s.dist	-0.78
p.adjustANOVA	1.79e-34

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
RPS27L	-2611
RPL26L1	-2572
RPL29	-2433
RPL4	-2374
RPL27A	-2238
RPS13	-2162
RPS6	-2137
RPL15	-2045
RPL17	-1968
RPLP0	-1966
RPL22L1	-985
RPL5	-485
RPL12	-443
RPS17	7
RPL31	20
RPL7	108
RPS2	319
RPS4X	1068
RPL9	1356
RPS11	1556
RPL23	1657
EEF2	2708
RPL39L	3853
RPL13A	5851
RPS20	6819
EEF1A1	7185

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	353
set	Formation of a pool of free 40S subunits
setSize	98
pANOVA	4.92e-40
s.dist	-0.773
p.adjustANOVA	7.11e-38

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
EIF3K	-3095
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
EIF3I	-2640
RPS27L	-2611
RPL26L1	-2572
RPL29	-2433
EIF3J	-2427
RPL4	-2374
RPL27A	-2238
EIF3D	-2163
RPS13	-2162
RPS6	-2137
RPL15	-2045
EIF3G	-2009
EIF3M	-1989
RPL17	-1968
RPLP0	-1966
RPL22L1	-985
EIF1AX	-952
RPL5	-485
RPL12	-443
RPS17	7
RPL31	20
EIF3F	71
RPL7	108
EIF3L	121
EIF3E	252
RPS2	319
EIF3H	376
RPS4X	1068
RPL9	1356
RPS11	1556
RPL23	1657
EIF3A	2251
EIF3B	3737
RPL39L	3853
RPL13A	5851
RPS20	6819

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	986
set	SRP-dependent cotranslational protein targeting to membrane
setSize	109
pANOVA	4.36e-44
s.dist	-0.771
p.adjustANOVA	1.42e-41

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
SPCS2	-3137
RPS9	-3133
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
RPS14	-3088
SEC61G	-3077
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
SSR4	-2999
RPS27	-2985
SRP14	-2976
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
SSR3	-2931
SEC61B	-2927
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
SSR2	-2823
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
SPCS3	-2728
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
SEC11C	-2673
RPL6	-2665
RPS27L	-2611
RPL26L1	-2572
SRPRB	-2462
RPL29	-2433
DDOST	-2414
RPL4	-2374
RPL27A	-2238
RPN2	-2180
RPS13	-2162
SEC11A	-2141
RPS6	-2137
SRP9	-2106
RPL15	-2045
RPL17	-1968
RPLP0	-1966
SRPRA	-1035
RPL22L1	-985
SRP68	-746
SEC61A1	-605
RPL5	-485
RPL12	-443
SRP19	-235
RPS17	7
RPL31	20
RPL7	108
RPN1	204
RPS2	319
SPCS1	403
TRAM1	581
RPS4X	1068
RPL9	1356
RPS11	1556
SRP72	1654
RPL23	1657
RPL39L	3853
SSR1	3991
SRP54	4755
RPL13A	5851
RPS20	6819

---

SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery

	970
set	SARS-CoV-1 modulates host translation machinery
setSize	36
pANOVA	1.67e-15
s.dist	-0.767
p.adjustANOVA	2.35e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPS29	-3247
RPS21	-3244
RPS18	-3220
RPS26	-3215
FAU	-3209
RPS15	-3207
RPS12	-3173
RPS24	-3160
RPSA	-3139
RPS9	-3133
RPS5	-3098
RPS14	-3088
RPS7	-3072
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPS8	-2950
RPS25	-2902
RPS3	-2869

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPS29	-3247
RPS21	-3244
RPS18	-3220
RPS26	-3215
FAU	-3209
RPS15	-3207
RPS12	-3173
RPS24	-3160
RPSA	-3139
RPS9	-3133
RPS5	-3098
RPS14	-3088
RPS7	-3072
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPS8	-2950
RPS25	-2902
RPS3	-2869
RPS27A	-2821
RPS23	-2783
RPS4Y1	-2771
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPS27L	-2611
HNRNPA1	-2478
RPS13	-2162
RPS6	-2137
RPS17	7
RPS2	319
RPS4X	1068
RPS11	1556
RPS20	6819
EEF1A1	7185

---

Selenocysteine synthesis

Selenocysteine synthesis

	1006
set	Selenocysteine synthesis
setSize	90
pANOVA	7.1e-36
s.dist	-0.761
p.adjustANOVA	4.86e-34

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
RPS27L	-2611
RPL26L1	-2572
RPL29	-2433
RPL4	-2374
RPL27A	-2238
RPS13	-2162
RPS6	-2137
RPL15	-2045
RPL17	-1968
RPLP0	-1966
RPL22L1	-985
RPL5	-485
RPL12	-443
RPS17	7
RPL31	20
RPL7	108
RPS2	319
SEPSECS	448
RPS4X	1068
SEPHS2	1328
RPL9	1356
RPS11	1556
RPL23	1657
PSTK	1750
EEFSEC	3673
RPL39L	3853
SECISBP2	5516
RPL13A	5851
RPS20	6819

---

Folding of actin by CCT/TriC

Folding of actin by CCT/TriC

	344
set	Folding of actin by CCT/TriC
setSize	10
pANOVA	3.37e-05
s.dist	-0.757
p.adjustANOVA	0.000205

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACTB	-3267
CCT8	-2762
CCT7	-2743
CCT4	-2649
CCT3	-2593
CCT2	-2573
CCT5	-2406
TCP1	-1872
CCT6A	139
CCT6B	1343

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACTB	-3267
CCT8	-2762
CCT7	-2743
CCT4	-2649
CCT3	-2593
CCT2	-2573
CCT5	-2406
TCP1	-1872
CCT6A	139
CCT6B	1343

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	687
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	93
pANOVA	1.37e-35
s.dist	-0.746
p.adjustANOVA	8.46e-34

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
RPS27L	-2611
RPL26L1	-2572
RPL29	-2433
RPL4	-2374
RPL27A	-2238
RPS13	-2162
RPS6	-2137
RPL15	-2045
RPL17	-1968
RPLP0	-1966
GSPT2	-1653
RPL22L1	-985
RPL5	-485
RPL12	-443
NCBP2	-191
GSPT1	-159
RPS17	7
RPL31	20
RPL7	108
RPS2	319
ETF1	467
RPS4X	1068
RPL9	1356
RPS11	1556
RPL23	1657
UPF1	2667
EIF4G1	2728
NCBP1	3424
RPL39L	3853
RPL13A	5851
RPS20	6819
PABPC1	7504

---

SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery

	976
set	SARS-CoV-2 modulates host translation machinery
setSize	47
pANOVA	8.64e-19
s.dist	-0.746
p.adjustANOVA	2.39e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPS29	-3247
RPS21	-3244
RPS18	-3220
RPS26	-3215
FAU	-3209
RPS15	-3207
RPS12	-3173
RPS24	-3160
RPSA	-3139
RPS9	-3133
RPS5	-3098
RPS14	-3088
RPS7	-3072
RPS16	-3045
RPS15A	-3005
SNRPD1	-2998
RPS27	-2985
SNRPD2	-2978
RPS8	-2950

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPS29	-3247
RPS21	-3244
RPS18	-3220
RPS26	-3215
FAU	-3209
RPS15	-3207
RPS12	-3173
RPS24	-3160
RPSA	-3139
RPS9	-3133
RPS5	-3098
RPS14	-3088
RPS7	-3072
RPS16	-3045
RPS15A	-3005
SNRPD1	-2998
RPS27	-2985
SNRPD2	-2978
RPS8	-2950
SNRPF	-2934
RPS25	-2902
SNRPG	-2874
RPS3	-2869
SNRPB	-2830
RPS27A	-2821
RPS23	-2783
SNRPE	-2776
RPS4Y1	-2771
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPS27L	-2611
RPS13	-2162
RPS6	-2137
GEMIN6	-1391
GEMIN7	-870
SNRPD3	-150
RPS17	7
RPS2	319
RPS4X	1068
GEMIN5	1449
RPS11	1556
DDX20	1757
GEMIN8	2496
GEMIN2	2558
RPS20	6819

---

Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling

	345
set	Formation of ATP by chemiosmotic coupling
setSize	18
pANOVA	6.58e-08
s.dist	-0.735
p.adjustANOVA	5.45e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP5MF	-3261
ATP5F1E	-3260
ATP5ME	-3233
ATP5MC3	-3201
ATP5MG	-3168
ATP5PD	-3162
ATP5MC2	-3158
ATP5PF	-3132
ATP5MC1	-3120
ATP5F1D	-3106
ATP5F1B	-3039
ATP5PO	-2940
ATP5PB	-2817
ATP5F1C	-2738
ATP5F1A	-2508
DMAC2L	-1795
MT-ATP6	7354
MT-ATP8	7606

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP5MF	-3261
ATP5F1E	-3260
ATP5ME	-3233
ATP5MC3	-3201
ATP5MG	-3168
ATP5PD	-3162
ATP5MC2	-3158
ATP5PF	-3132
ATP5MC1	-3120
ATP5F1D	-3106
ATP5F1B	-3039
ATP5PO	-2940
ATP5PB	-2817
ATP5F1C	-2738
ATP5F1A	-2508
DMAC2L	-1795
MT-ATP6	7354
MT-ATP8	7606

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	394
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	109
pANOVA	4.48e-39
s.dist	-0.724
p.adjustANOVA	5.3e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
EIF4A1	-3130
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
EIF3K	-3095
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
EIF3I	-2640
RPS27L	-2611
EIF4E	-2583
RPL26L1	-2572
EIF5B	-2440
RPL29	-2433
EIF3J	-2427
RPL4	-2374
RPL27A	-2238
EIF3D	-2163
RPS13	-2162
RPS6	-2137
RPL15	-2045
EIF3G	-2009
EIF3M	-1989
RPL17	-1968
RPLP0	-1966
EIF2S1	-1641
RPL22L1	-985
EIF1AX	-952
EIF2S2	-901
RPL5	-485
RPL12	-443
RPS17	7
RPL31	20
EIF3F	71
RPL7	108
EIF3L	121
EIF3E	252
RPS2	319
EIF4H	357
EIF3H	376
EIF2S3	459
RPS4X	1068
RPL9	1356
RPS11	1556
RPL23	1657
EIF3A	2251
EIF5	2257
EIF4G1	2728
EIF3B	3737
RPL39L	3853
EIF4A2	4936
RPL13A	5851
RPS20	6819
EIF4B	7359

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

	360
set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	50
pANOVA	1e-18
s.dist	-0.722
p.adjustANOVA	2.71e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPS29	-3247
RPS21	-3244
RPS18	-3220
RPS26	-3215
FAU	-3209
RPS15	-3207
RPS12	-3173
RPS24	-3160
RPSA	-3139
RPS9	-3133
RPS5	-3098
EIF3K	-3095
RPS14	-3088
RPS7	-3072
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPS8	-2950
RPS25	-2902

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPS29	-3247
RPS21	-3244
RPS18	-3220
RPS26	-3215
FAU	-3209
RPS15	-3207
RPS12	-3173
RPS24	-3160
RPSA	-3139
RPS9	-3133
RPS5	-3098
EIF3K	-3095
RPS14	-3088
RPS7	-3072
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPS8	-2950
RPS25	-2902
RPS3	-2869
RPS27A	-2821
RPS23	-2783
RPS4Y1	-2771
RPS10	-2749
RPS3A	-2745
RPS19	-2714
EIF3I	-2640
RPS27L	-2611
EIF3J	-2427
EIF3D	-2163
RPS13	-2162
RPS6	-2137
EIF3G	-2009
EIF3M	-1989
EIF2S1	-1641
EIF1AX	-952
EIF2S2	-901
RPS17	7
EIF3F	71
EIF3L	121
EIF3E	252
RPS2	319
EIF3H	376
EIF2S3	459
RPS4X	1068
RPS11	1556
EIF3A	2251
EIF3B	3737
RPS20	6819

---

Selenoamino acid metabolism

Selenoamino acid metabolism

	1005
set	Selenoamino acid metabolism
setSize	101
pANOVA	2.25e-35
s.dist	-0.714
p.adjustANOVA	1.27e-33

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
RPS27L	-2611
RPL26L1	-2572
RPL29	-2433
RPL4	-2374
AHCY	-2293
RPL27A	-2238
RPS13	-2162
RPS6	-2137
AIMP1	-2119
RPL15	-2045
HNMT	-1976
RPL17	-1968
RPLP0	-1966
RPL22L1	-985
PAPSS1	-774
AIMP2	-550
EEF1E1	-535
RPL5	-485
RPL12	-443
GSR	-417
RPS17	7
RPL31	20
RPL7	108
RPS2	319
SEPSECS	448
CTH	706
RPS4X	1068
SEPHS2	1328
RPL9	1356
RPS11	1556
RPL23	1657
PSTK	1750
TXNRD1	1901
EEFSEC	3673
RPL39L	3853
SCLY	3855
SECISBP2	5516
RPL13A	5851
RPS20	6819
PAPSS2	7415

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	541
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	108
pANOVA	1.11e-37
s.dist	-0.714
p.adjustANOVA	8.98e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
EIF4A1	-3130
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
EIF3K	-3095
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
EIF3I	-2640
RPS27L	-2611
EIF4E	-2583
RPL26L1	-2572
RPL29	-2433
EIF3J	-2427
RPL4	-2374
RPL27A	-2238
EIF3D	-2163
RPS13	-2162
RPS6	-2137
RPL15	-2045
EIF3G	-2009
EIF3M	-1989
RPL17	-1968
RPLP0	-1966
EIF2S1	-1641
RPL22L1	-985
EIF1AX	-952
EIF2S2	-901
RPL5	-485
RPL12	-443
RPS17	7
RPL31	20
EIF3F	71
RPL7	108
EIF3L	121
EIF3E	252
RPS2	319
EIF4H	357
EIF3H	376
EIF2S3	459
RPS4X	1068
RPL9	1356
RPS11	1556
RPL23	1657
EIF3A	2251
EIF4G1	2728
EIF3B	3737
RPL39L	3853
EIF4A2	4936
RPL13A	5851
RPS20	6819
EIF4B	7359
PABPC1	7504

---

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

	192
set	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
setSize	25
pANOVA	7.36e-10
s.dist	-0.711
p.adjustANOVA	6.69e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACTB	-3267
PFDN5	-3192
TUBA1B	-3174
PFDN2	-3122
PFDN6	-2895
TUBB4B	-2873
CCT8	-2762
CCT7	-2743
TUBA1A	-2711
CCT4	-2649
CCT3	-2593
CCT2	-2573
VBP1	-2454
CCT5	-2406
TUBB2A	-2354
PFDN4	-2166
TUBA1C	-1994
TCP1	-1872
TUBB3	-1433
TUBB6	-1363

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACTB	-3267
PFDN5	-3192
TUBA1B	-3174
PFDN2	-3122
PFDN6	-2895
TUBB4B	-2873
CCT8	-2762
CCT7	-2743
TUBA1A	-2711
CCT4	-2649
CCT3	-2593
CCT2	-2573
VBP1	-2454
CCT5	-2406
TUBB2A	-2354
PFDN4	-2166
TUBA1C	-1994
TCP1	-1872
TUBB3	-1433
TUBB6	-1363
CCT6A	139
PFDN1	390
CCT6B	1343
TUBA4A	2254
TUBB4A	4421

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

	955
set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	98
pANOVA	3.95e-34
s.dist	-0.711
p.adjustANOVA	1.97e-32

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
RPS27L	-2611
RPL26L1	-2572
RPL29	-2433
RPL4	-2374
RPL27A	-2238
RPS13	-2162
RPS6	-2137
RPL15	-2045
RPL17	-1968
RPLP0	-1966
EIF2S1	-1641
RPL22L1	-985
EIF2S2	-901
RPL5	-485
RPL12	-443
RPS17	7
RPL31	20
DDIT3	76
TRIB3	100
RPL7	108
CEBPB	164
RPS2	319
ATF3	359
EIF2S3	459
IMPACT	782
RPS4X	1068
RPL9	1356
RPS11	1556
RPL23	1657
CEBPG	3027
GCN1	3507
RPL39L	3853
EIF2AK4	5654
RPL13A	5851
ATF2	5852
ATF4	6813
RPS20	6819

---

Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation

	927
set	Regulation of activated PAK-2p34 by proteasome mediated degradation
setSize	48
pANOVA	1.97e-17
s.dist	-0.708
p.adjustANOVA	4.42e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
PAK2	1997
PSMD5	4230
PSME4	6251

---

Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs

	930
set	Regulation of expression of SLITs and ROBOs
setSize	155
pANOVA	2.56e-52
s.dist	-0.707
p.adjustANOVA	1.11e-49

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
RPL35A	-3125
RPL37	-3121
RPL11	-3116
PSMB6	-3105
RPS5	-3098
RPS14	-3088
RBX1	-3082
RPS7	-3072
RPL30	-3071
ELOB	-3061
RPL10A	-3051
RPL14	-3046
RPS16	-3045
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
RPS15A	-3005
ELOC	-2992
RPS27	-2985
PSMB1	-2979
SEM1	-2968
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
PSMA4	-2929
RPL28	-2926
RPL27	-2923
MAGOH	-2915
RPS25	-2902
UBC	-2887
PSMD7	-2885
RPS3	-2869
PSMB7	-2865
RPL36A	-2858
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
RPL22	-2796
RPL23A	-2793
PSMA3	-2787
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
PSMB8	-2753
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
RPL6	-2665
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
RBM8A	-2629
RPS27L	-2611
RPL26L1	-2572
RPL29	-2433
EIF4A3	-2404
PSMA1	-2401
RPL4	-2374
PSME2	-2323
RPL27A	-2238
PSMD4	-2233
MAGOHB	-2230
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
RPS13	-2162
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
RPS6	-2137
PSMC5	-2073
PSMC6	-2047
RPL15	-2045
PSMD1	-2012
RNPS1	-1986
RPL17	-1968
RPLP0	-1966
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
GSPT2	-1653
PSMD14	-1585
PSMB4	-1579
RPL22L1	-985
UPF2	-976
UBB	-975
PSMD10	-847
PSMB9	-715
RPL5	-485
PSMF1	-455
RPL12	-443
PSMD3	-416
UPF3A	-359
PSMD11	-307
NCBP2	-191
GSPT1	-159
PSME3	-153
ZSWIM8	-145
RPS17	7
RPL31	20
RPL7	108
RPS2	319
ETF1	467
PSMB5	486
DAG1	830
CASC3	968
RPS4X	1068
PSMD12	1198
RPL9	1356
RPS11	1556
RPL23	1657
CUL2	1764
EIF4G1	2728
NCBP1	3424
RPL39L	3853
PSMD5	4230
UPF3B	4280
ROBO3	4727
LDB1	4935
USP33	5060
RPL13A	5851
PSME4	6251
RPS20	6819
PABPC1	7504

---

Regulation of ornithine decarboxylase (ODC)

Regulation of ornithine decarboxylase (ODC)

	939
set	Regulation of ornithine decarboxylase (ODC)
setSize	49
pANOVA	1.23e-17
s.dist	-0.706
p.adjustANOVA	2.92e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
OAZ1	-2912
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
OAZ1	-2912
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
NQO1	-2131
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
OAZ2	-1964
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
OAZ3	-1610
PSMD14	-1585
PSMB4	-1579
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
ODC1	-336
PSMD11	-307
PSME3	-153
AZIN1	129
PSMB5	486
PSMD12	1198
PSMD5	4230
PSME4	6251

---

Mitochondrial translation elongation

Mitochondrial translation elongation

	616
set	Mitochondrial translation elongation
setSize	88
pANOVA	2.82e-30
s.dist	-0.705
p.adjustANOVA	1.18e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS36	-3096
MRPS34	-3052
MRPL41	-3040
MRPL54	-3016
MRPL52	-2988
MRPS24	-2986
GADD45GIP1	-2980
MRPS12	-2910
MRPS7	-2883
MRPL47	-2881
MRPS18C	-2864
AURKAIP1	-2856
MRPL20	-2854
MRPS6	-2853
MRPL12	-2852
MRPL36	-2818
MRPL57	-2811
MRPL11	-2801
MRPL33	-2799
MRPL34	-2778

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS36	-3096
MRPS34	-3052
MRPL41	-3040
MRPL54	-3016
MRPL52	-2988
MRPS24	-2986
GADD45GIP1	-2980
MRPS12	-2910
MRPS7	-2883
MRPL47	-2881
MRPS18C	-2864
AURKAIP1	-2856
MRPL20	-2854
MRPS6	-2853
MRPL12	-2852
MRPL36	-2818
MRPL57	-2811
MRPL11	-2801
MRPL33	-2799
MRPL34	-2778
MRPL14	-2769
MRPS25	-2756
MRPL51	-2741
MRPL35	-2735
MRPL2	-2723
MRPL22	-2715
MRPL21	-2709
CHCHD1	-2708
TUFM	-2698
MRPL28	-2672
MRPL27	-2643
MRPS17	-2596
MRPL40	-2570
MRPL13	-2561
MRPS21	-2525
MRPL23	-2523
MRPS16	-2512
MRPL55	-2507
MRPL4	-2468
MRPS11	-2464
MRPL16	-2435
MRPS15	-2368
MRPS18A	-2341
MRPS33	-2327
MRPS18B	-2282
MRPS35	-2221
MRPS23	-2202
MRPL50	-2192
MRPL17	-2143
MRPL15	-2128
MRPS22	-2108
MRPL24	-2101
MRPL38	-2001
MRPL39	-1804
MRPL10	-1715
MRPS10	-1709
MRPS26	-1707
GFM1	-1632
MRPS2	-1506
ERAL1	-1319
MRPL32	-1269
MRPL53	-1256
MRPL42	-1112
MRPL48	-829
MRPL19	-796
MRPL58	-782
MRPL46	-706
MRPS14	-687
MRPS5	-640
MRPS28	-495
MRPL30	-283
MRPL45	-173
MRPL44	-137
MRPL18	-55
MRPL37	44
MRPL43	46
MRPL3	115
DAP3	242
TSFM	243
MRPL1	323
MRPS31	441
MRPS30	475
MRPS27	1255
MRPL9	1287
OXA1L	1294
MRPL49	3110
MRPS9	4099
PTCD3	4414

---

Prefoldin mediated transfer of substrate to CCT/TriC

Prefoldin mediated transfer of substrate to CCT/TriC

	781
set	Prefoldin mediated transfer of substrate to CCT/TriC
setSize	24
pANOVA	2.91e-09
s.dist	-0.7
p.adjustANOVA	2.54e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACTB	-3267
PFDN5	-3192
PFDN2	-3122
PFDN6	-2895
TUBB4B	-2873
CCT8	-2762
CCT7	-2743
TUBA1A	-2711
CCT4	-2649
CCT3	-2593
CCT2	-2573
VBP1	-2454
CCT5	-2406
TUBB2A	-2354
PFDN4	-2166
TUBA1C	-1994
TCP1	-1872
TUBB3	-1433
TUBB6	-1363
CCT6A	139

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACTB	-3267
PFDN5	-3192
PFDN2	-3122
PFDN6	-2895
TUBB4B	-2873
CCT8	-2762
CCT7	-2743
TUBA1A	-2711
CCT4	-2649
CCT3	-2593
CCT2	-2573
VBP1	-2454
CCT5	-2406
TUBB2A	-2354
PFDN4	-2166
TUBA1C	-1994
TCP1	-1872
TUBB3	-1433
TUBB6	-1363
CCT6A	139
PFDN1	390
CCT6B	1343
TUBA4A	2254
TUBB4A	4421

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

	125
set	Cap-dependent Translation Initiation
setSize	116
pANOVA	9.08e-39
s.dist	-0.699
p.adjustANOVA	8.43e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
EIF4A1	-3130
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
EIF3K	-3095
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
EIF4EBP1	-2694
RPL6	-2665
EIF3I	-2640
RPS27L	-2611
EIF4E	-2583
RPL26L1	-2572
EIF5B	-2440
RPL29	-2433
EIF3J	-2427
RPL4	-2374
RPL27A	-2238
EIF3D	-2163
RPS13	-2162
RPS6	-2137
RPL15	-2045
EIF3G	-2009
EIF3M	-1989
RPL17	-1968
RPLP0	-1966
EIF2S1	-1641
RPL22L1	-985
EIF1AX	-952
EIF2S2	-901
EIF2B4	-772
EIF2B1	-660
EIF2B5	-615
RPL5	-485
RPL12	-443
RPS17	7
RPL31	20
EIF3F	71
RPL7	108
EIF3L	121
EIF3E	252
EIF2B3	278
RPS2	319
EIF4H	357
EIF3H	376
EIF2S3	459
EIF2B2	792
RPS4X	1068
RPL9	1356
RPS11	1556
RPL23	1657
EIF3A	2251
EIF5	2257
EIF4G1	2728
EIF3B	3737
RPL39L	3853
EIF4A2	4936
RPL13A	5851
RPS20	6819
EIF4B	7359
PABPC1	7504

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

	316
set	Eukaryotic Translation Initiation
setSize	116
pANOVA	9.08e-39
s.dist	-0.699
p.adjustANOVA	8.43e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS28	-3265
RPL36	-3263
RPL35	-3250
RPS29	-3247
RPS21	-3244
RPL32	-3239
RPL19	-3232
RPL39	-3228
UBA52	-3224
RPS18	-3220
RPS26	-3215
RPLP2	-3212
FAU	-3209
RPS15	-3207
RPLP1	-3206
RPL41	-3204
RPL38	-3177
RPS12	-3173
RPL34	-3171
RPS24	-3160
RPL13	-3154
RPL18A	-3141
RPL37A	-3140
RPSA	-3139
RPS9	-3133
EIF4A1	-3130
RPL35A	-3125
RPL37	-3121
RPL11	-3116
RPS5	-3098
EIF3K	-3095
RPS14	-3088
RPS7	-3072
RPL30	-3071
RPL10A	-3051
RPL14	-3046
RPS16	-3045
RPS15A	-3005
RPS27	-2985
RPL24	-2957
RPL8	-2956
RPS8	-2950
RPL10	-2947
RPL21	-2945
RPL28	-2926
RPL27	-2923
RPS25	-2902
RPS3	-2869
RPL36A	-2858
RPS27A	-2821
RPL22	-2796
RPL23A	-2793
RPS23	-2783
RPL3	-2782
RPL26	-2774
RPS4Y1	-2771
RPL7A	-2766
RPS10	-2749
RPS3A	-2745
RPS19	-2714
RPL36AL	-2703
RPL18	-2699
EIF4EBP1	-2694
RPL6	-2665
EIF3I	-2640
RPS27L	-2611
EIF4E	-2583
RPL26L1	-2572
EIF5B	-2440
RPL29	-2433
EIF3J	-2427
RPL4	-2374
RPL27A	-2238
EIF3D	-2163
RPS13	-2162
RPS6	-2137
RPL15	-2045
EIF3G	-2009
EIF3M	-1989
RPL17	-1968
RPLP0	-1966
EIF2S1	-1641
RPL22L1	-985
EIF1AX	-952
EIF2S2	-901
EIF2B4	-772
EIF2B1	-660
EIF2B5	-615
RPL5	-485
RPL12	-443
RPS17	7
RPL31	20
EIF3F	71
RPL7	108
EIF3L	121
EIF3E	252
EIF2B3	278
RPS2	319
EIF4H	357
EIF3H	376
EIF2S3	459
EIF2B2	792
RPS4X	1068
RPL9	1356
RPS11	1556
RPL23	1657
EIF3A	2251
EIF5	2257
EIF4G1	2728
EIF3B	3737
RPL39L	3853
EIF4A2	4936
RPL13A	5851
RPS20	6819
EIF4B	7359
PABPC1	7504

---

Vpu mediated degradation of CD4

Vpu mediated degradation of CD4

	1263
set	Vpu mediated degradation of CD4
setSize	50
pANOVA	1.86e-17
s.dist	-0.695
p.adjustANOVA	4.25e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
CD4	-1497
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
PSMD5	4230
PSME4	6251
BTRC	6965

---

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

	323
set	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
setSize	52
pANOVA	4.72e-18
s.dist	-0.694
p.adjustANOVA	1.18e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
RBX1	-3082
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
RBX1	-3082
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
FBXL18	-1423
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
AURKA	1590
PSMD5	4230
CUL1	5483
PSME4	6251

---

Negative regulation of NOTCH4 signaling

Negative regulation of NOTCH4 signaling

	669
set	Negative regulation of NOTCH4 signaling
setSize	53
pANOVA	3.73e-18
s.dist	-0.689
p.adjustANOVA	9.52e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
RBX1	-3082
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
RBX1	-3082
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
YWHAZ	-2463
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
AKT1	-1013
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
TACC3	2670
PSMD5	4230
CUL1	5483
FBXW7	6947

---

Mitochondrial translation initiation

Mitochondrial translation initiation

	617
set	Mitochondrial translation initiation
setSize	88
pANOVA	5.03e-29
s.dist	-0.689
p.adjustANOVA	1.92e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS36	-3096
MRPS34	-3052
MRPL41	-3040
MRPL54	-3016
MRPL52	-2988
MRPS24	-2986
GADD45GIP1	-2980
MRPS12	-2910
MRPS7	-2883
MRPL47	-2881
MRPS18C	-2864
AURKAIP1	-2856
MRPL20	-2854
MRPS6	-2853
MRPL12	-2852
MRPL36	-2818
MRPL57	-2811
MRPL11	-2801
MRPL33	-2799
MRPL34	-2778

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS36	-3096
MRPS34	-3052
MRPL41	-3040
MRPL54	-3016
MRPL52	-2988
MRPS24	-2986
GADD45GIP1	-2980
MRPS12	-2910
MRPS7	-2883
MRPL47	-2881
MRPS18C	-2864
AURKAIP1	-2856
MRPL20	-2854
MRPS6	-2853
MRPL12	-2852
MRPL36	-2818
MRPL57	-2811
MRPL11	-2801
MRPL33	-2799
MRPL34	-2778
MRPL14	-2769
MRPS25	-2756
MRPL51	-2741
MRPL35	-2735
MRPL2	-2723
MRPL22	-2715
MRPL21	-2709
CHCHD1	-2708
MRPL28	-2672
MRPL27	-2643
MRPS17	-2596
MRPL40	-2570
MRPL13	-2561
MRPS21	-2525
MRPL23	-2523
MRPS16	-2512
MRPL55	-2507
MRPL4	-2468
MRPS11	-2464
MRPL16	-2435
MRPS15	-2368
MRPS18A	-2341
MRPS33	-2327
MRPS18B	-2282
MRPS35	-2221
MRPS23	-2202
MRPL50	-2192
MRPL17	-2143
MRPL15	-2128
MRPS22	-2108
MRPL24	-2101
MRPL38	-2001
MRPL39	-1804
MRPL10	-1715
MRPS10	-1709
MRPS26	-1707
MRPS2	-1506
ERAL1	-1319
MRPL32	-1269
MRPL53	-1256
MTIF3	-1168
MRPL42	-1112
MRPL48	-829
MRPL19	-796
MRPL58	-782
MRPL46	-706
MRPS14	-687
MRPS5	-640
MRPS28	-495
MRPL30	-283
MRPL45	-173
MRPL44	-137
MRPL18	-55
MRPL37	44
MRPL43	46
MRPL3	115
DAP3	242
MRPL1	323
MRPS31	441
MRPS30	475
MRPS27	1255
MTFMT	1275
MRPL9	1287
OXA1L	1294
MRPL49	3110
MTIF2	3204
MRPS9	4099
PTCD3	4414

---

Mitochondrial translation termination

Mitochondrial translation termination

	618
set	Mitochondrial translation termination
setSize	88
pANOVA	7.65e-29
s.dist	-0.687
p.adjustANOVA	2.84e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS36	-3096
MRPS34	-3052
MRPL41	-3040
MRPL54	-3016
MRPL52	-2988
MRPS24	-2986
GADD45GIP1	-2980
MRPS12	-2910
MRPS7	-2883
MRPL47	-2881
MRPS18C	-2864
AURKAIP1	-2856
MRPL20	-2854
MRPS6	-2853
MRPL12	-2852
MRPL36	-2818
MRPL57	-2811
MRPL11	-2801
MRPL33	-2799
MRPL34	-2778

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS36	-3096
MRPS34	-3052
MRPL41	-3040
MRPL54	-3016
MRPL52	-2988
MRPS24	-2986
GADD45GIP1	-2980
MRPS12	-2910
MRPS7	-2883
MRPL47	-2881
MRPS18C	-2864
AURKAIP1	-2856
MRPL20	-2854
MRPS6	-2853
MRPL12	-2852
MRPL36	-2818
MRPL57	-2811
MRPL11	-2801
MRPL33	-2799
MRPL34	-2778
MRPL14	-2769
MRPS25	-2756
MRPL51	-2741
MRPL35	-2735
MRPL2	-2723
MRPL22	-2715
MRPL21	-2709
CHCHD1	-2708
MRPL28	-2672
MRPL27	-2643
MRPS17	-2596
MRPL40	-2570
MRPL13	-2561
MRPS21	-2525
MRPL23	-2523
MRPS16	-2512
MRPL55	-2507
MRPL4	-2468
MRPS11	-2464
MRPL16	-2435
MRPS15	-2368
MRPS18A	-2341
MRPS33	-2327
MRPS18B	-2282
MRPS35	-2221
MRPS23	-2202
MRPL50	-2192
MRPL17	-2143
MRPL15	-2128
MRPS22	-2108
MRPL24	-2101
MRPL38	-2001
MRPL39	-1804
MRPL10	-1715
MRPS10	-1709
MRPS26	-1707
MRPS2	-1506
ERAL1	-1319
MRPL32	-1269
MRPL53	-1256
MRRF	-1231
MRPL42	-1112
MRPL48	-829
MRPL19	-796
MRPL58	-782
MRPL46	-706
MRPS14	-687
MRPS5	-640
MRPS28	-495
MRPL30	-283
MRPL45	-173
MRPL44	-137
MRPL18	-55
MRPL37	44
MRPL43	46
MRPL3	115
DAP3	242
MRPL1	323
MRPS31	441
MRPS30	475
MRPS27	1255
MRPL9	1287
OXA1L	1294
MTRF1L	1940
MRPL49	3110
GFM2	3694
MRPS9	4099
PTCD3	4414

---

Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D

	1246
set	Ubiquitin-dependent degradation of Cyclin D
setSize	50
pANOVA	4.94e-17
s.dist	-0.685
p.adjustANOVA	1e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
CDK4	-2345
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
CCND1	-163
PSME3	-153
PSMB5	486
PSMD12	1198
PSMD5	4230
PSME4	6251
GSK3B	7481

---

Somitogenesis

Somitogenesis

	1107
set	Somitogenesis
setSize	46
pANOVA	1.33e-15
s.dist	-0.681
p.adjustANOVA	1.92e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
LFNG	-176
PSME3	-153
PSMB5	486
NOTCH1	1058
PSMD12	1198
CTNNB1	3498
RBPJ	4158
PSMD5	4230

---

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

	1245
set	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
setSize	49
pANOVA	1.63e-16
s.dist	-0.681
p.adjustANOVA	3.02e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
CHEK2	1574
PSMD5	4230
CHEK1	6178
PSME4	6251

---

p53-Independent DNA Damage Response

p53-Independent DNA Damage Response

	1285
set	p53-Independent DNA Damage Response
setSize	49
pANOVA	1.63e-16
s.dist	-0.681
p.adjustANOVA	3.02e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
CHEK2	1574
PSMD5	4230
CHEK1	6178
PSME4	6251

---

p53-Independent G1/S DNA damage checkpoint

p53-Independent G1/S DNA damage checkpoint

	1286
set	p53-Independent G1/S DNA damage checkpoint
setSize	49
pANOVA	1.63e-16
s.dist	-0.681
p.adjustANOVA	3.02e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
CHEK2	1574
PSMD5	4230
CHEK1	6178
PSME4	6251

---

Vif-mediated degradation of APOBEC3G

Vif-mediated degradation of APOBEC3G

	1256
set	Vif-mediated degradation of APOBEC3G
setSize	53
pANOVA	1.49e-17
s.dist	-0.677
p.adjustANOVA	3.46e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
RBX1	-3082
ELOB	-3061
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
ELOC	-2992
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
RBX1	-3082
ELOB	-3061
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
ELOC	-2992
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
APOBEC3G	-1522
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
PSMD5	4230
CUL5	5887
PSME4	6251
vif	7664

---

Autodegradation of the E3 ubiquitin ligase COP1

Autodegradation of the E3 ubiquitin ligase COP1

	80
set	Autodegradation of the E3 ubiquitin ligase COP1
setSize	49
pANOVA	3.92e-16
s.dist	-0.672
p.adjustANOVA	5.92e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
TP53	2656
PSMD5	4230
PSME4	6251
ATM	7406

---

SCF(Skp2)-mediated degradation of p27/p21

SCF(Skp2)-mediated degradation of p27/p21

	979
set	SCF(Skp2)-mediated degradation of p27/p21
setSize	55
pANOVA	6.58e-18
s.dist	-0.672
p.adjustANOVA	1.61e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
CDK4	-2345
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
SKP2	-1749
PSMD14	-1585
PSMB4	-1579
CKS1B	-1198
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
CCND1	-163
PSME3	-153
CCNA1	377
PSMB5	486
PSMD12	1198
CDKN1B	3342
PSMD5	4230
CUL1	5483
CDKN1A	6998

---

Mitochondrial translation

Mitochondrial translation

	615
set	Mitochondrial translation
setSize	94
pANOVA	2.43e-29
s.dist	-0.671
p.adjustANOVA	9.86e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS36	-3096
MRPS34	-3052
MRPL41	-3040
MRPL54	-3016
MRPL52	-2988
MRPS24	-2986
GADD45GIP1	-2980
MRPS12	-2910
MRPS7	-2883
MRPL47	-2881
MRPS18C	-2864
AURKAIP1	-2856
MRPL20	-2854
MRPS6	-2853
MRPL12	-2852
MRPL36	-2818
MRPL57	-2811
MRPL11	-2801
MRPL33	-2799
MRPL34	-2778

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS36	-3096
MRPS34	-3052
MRPL41	-3040
MRPL54	-3016
MRPL52	-2988
MRPS24	-2986
GADD45GIP1	-2980
MRPS12	-2910
MRPS7	-2883
MRPL47	-2881
MRPS18C	-2864
AURKAIP1	-2856
MRPL20	-2854
MRPS6	-2853
MRPL12	-2852
MRPL36	-2818
MRPL57	-2811
MRPL11	-2801
MRPL33	-2799
MRPL34	-2778
MRPL14	-2769
MRPS25	-2756
MRPL51	-2741
MRPL35	-2735
MRPL2	-2723
MRPL22	-2715
MRPL21	-2709
CHCHD1	-2708
TUFM	-2698
MRPL28	-2672
MRPL27	-2643
MRPS17	-2596
MRPL40	-2570
MRPL13	-2561
MRPS21	-2525
MRPL23	-2523
MRPS16	-2512
MRPL55	-2507
MRPL4	-2468
MRPS11	-2464
MRPL16	-2435
MRPS15	-2368
MRPS18A	-2341
MRPS33	-2327
MRPS18B	-2282
MRPS35	-2221
MRPS23	-2202
MRPL50	-2192
MRPL17	-2143
MRPL15	-2128
MRPS22	-2108
MRPL24	-2101
MRPL38	-2001
MRPL39	-1804
MRPL10	-1715
MRPS10	-1709
MRPS26	-1707
GFM1	-1632
MRPS2	-1506
ERAL1	-1319
MRPL32	-1269
MRPL53	-1256
MRRF	-1231
MTIF3	-1168
MRPL42	-1112
MRPL48	-829
MRPL19	-796
MRPL58	-782
MRPL46	-706
MRPS14	-687
MRPS5	-640
MRPS28	-495
MRPL30	-283
MRPL45	-173
MRPL44	-137
MRPL18	-55
MRPL37	44
MRPL43	46
MRPL3	115
DAP3	242
TSFM	243
MRPL1	323
MRPS31	441
MRPS30	475
MRPS27	1255
MTFMT	1275
MRPL9	1287
OXA1L	1294
MTRF1L	1940
MRPL49	3110
MTIF2	3204
GFM2	3694
MRPS9	4099
PTCD3	4414

---

Hh mutants are degraded by ERAD

Hh mutants are degraded by ERAD

	458
set	Hh mutants are degraded by ERAD
setSize	53
pANOVA	3.65e-17
s.dist	-0.669
p.adjustANOVA	7.85e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
DERL2	-2405

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
DERL2	-2405
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
PSMB9	-715
VCP	-549
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
ERLEC1	432
PSMB5	486
SYVN1	1083
PSMD12	1198
SEL1L	3218
OS9	3492
PSMD5	4230
PSME4	6251

---

AUF1 (hnRNP D0) binds and destabilizes mRNA

AUF1 (hnRNP D0) binds and destabilizes mRNA

	20
set	AUF1 (hnRNP D0) binds and destabilizes mRNA
setSize	53
pANOVA	4.34e-17
s.dist	-0.667
p.adjustANOVA	9.1e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
HSPA8	-3128
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
HSPA8	-3128
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
HSPB1	-1553
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
HNRNPD	-395
PSMD11	-307
PSME3	-153
PSMB5	486
HSPA1A	580
PSMD12	1198
EIF4G1	2728
PSMD5	4230
PSME4	6251
PABPC1	7504

---

SCF-beta-TrCP mediated degradation of Emi1

SCF-beta-TrCP mediated degradation of Emi1

	980
set	SCF-beta-TrCP mediated degradation of Emi1
setSize	51
pANOVA	1.95e-16
s.dist	-0.666
p.adjustANOVA	3.45e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
FZR1	-449
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
PSMD5	4230
CUL1	5483
PSME4	6251
BTRC	6965

---

GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

	393
set	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
setSize	52
pANOVA	1.04e-16
s.dist	-0.665
p.adjustANOVA	2.01e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
RBX1	-3082
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
RBX1	-3082
PSMA7	-3028
SKP1	-3020
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
NFE2L2	102
PSMB5	486
PSMD12	1198
PSMD5	4230
CUL1	5483
BTRC	6965
GSK3B	7481

---

Cross-presentation of soluble exogenous antigens (endosomes)

Cross-presentation of soluble exogenous antigens (endosomes)

	195
set	Cross-presentation of soluble exogenous antigens (endosomes)
setSize	46
pANOVA	6.16e-15
s.dist	-0.665
p.adjustANOVA	8.17e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
PSMD10	-847
PSMB9	-715
FCGR1A	-493
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
MRC2	1445
PSMD5	4230
MRC1	5400
PSME4	6251

---

Regulation of Apoptosis

Regulation of Apoptosis

	894
set	Regulation of Apoptosis
setSize	51
pANOVA	2.89e-16
s.dist	-0.662
p.adjustANOVA	4.75e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
OMA1	-1996
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
PAK2	1997
ARHGAP10	4001
PSMD5	4230
OPA1	6032
PSME4	6251

---

Formation of tubulin folding intermediates by CCT/TriC

Formation of tubulin folding intermediates by CCT/TriC

	361
set	Formation of tubulin folding intermediates by CCT/TriC
setSize	18
pANOVA	1.21e-06
s.dist	-0.661
p.adjustANOVA	8.76e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TUBA1B	-3174
TUBB4B	-2873
CCT8	-2762
CCT7	-2743
TUBA1A	-2711
CCT4	-2649
CCT3	-2593
CCT2	-2573
CCT5	-2406
TUBB2A	-2354
TUBA1C	-1994
TCP1	-1872
TUBB3	-1433
TUBB6	-1363
CCT6A	139
CCT6B	1343
TUBA4A	2254
TUBB4A	4421

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TUBA1B	-3174
TUBB4B	-2873
CCT8	-2762
CCT7	-2743
TUBA1A	-2711
CCT4	-2649
CCT3	-2593
CCT2	-2573
CCT5	-2406
TUBB2A	-2354
TUBA1C	-1994
TCP1	-1872
TUBB3	-1433
TUBB6	-1363
CCT6A	139
CCT6B	1343
TUBA4A	2254
TUBB4A	4421

---

The role of GTSE1 in G2/M progression after G2 checkpoint

The role of GTSE1 in G2/M progression after G2 checkpoint

	1176
set	The role of GTSE1 in G2/M progression after G2 checkpoint
setSize	63
pANOVA	1.26e-19
s.dist	-0.66
p.adjustANOVA	3.56e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
TUBA1B	-3174
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
HSP90AA1	-2884
TUBB4B	-2873
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
HSP90AB1	-2802
PSMA3	-2787
PSMB8	-2753

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
TUBA1B	-3174
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
HSP90AA1	-2884
TUBB4B	-2873
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
HSP90AB1	-2802
PSMA3	-2787
PSMB8	-2753
TUBA1A	-2711
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
TUBB2A	-2354
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
TUBA1C	-1994
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
TUBB3	-1433
TUBB6	-1363
MAPRE1	-1068
CCNB1	-1019
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
CCNB2	1383
TUBA4A	2254
TP53	2656
PSMD5	4230
TUBB4A	4421
PSME4	6251
CDKN1A	6998

---

Metabolism of polyamines

Metabolism of polyamines

	594
set	Metabolism of polyamines
setSize	54
pANOVA	4.87e-17
s.dist	-0.66
p.adjustANOVA	1e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB6	-3105
SMS	-3097
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
OAZ1	-2912
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
SRM	-2748
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB6	-3105
SMS	-3097
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
OAZ1	-2912
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
SRM	-2748
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
NQO1	-2131
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
OAZ2	-1964
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
OAZ3	-1610
PSMD14	-1585
PSMB4	-1579
PAOX	-1015
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
ODC1	-336
PSMD11	-307
PSME3	-153
AZIN1	129
PSMB5	486
PSMD12	1198
PSMD5	4230
AMD1	5905
PSME4	6251
SAT1	6324

---

Defective CFTR causes cystic fibrosis

Defective CFTR causes cystic fibrosis

	227
set	Defective CFTR causes cystic fibrosis
setSize	57
pANOVA	1.24e-17
s.dist	-0.654
p.adjustANOVA	2.92e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
DERL2	-2405

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
DERL2	-2405
PSMA1	-2401
DERL1	-2387
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
ERLIN2	-837
PSMB9	-715
VCP	-549
PSMF1	-455
RNF5	-422
PSMD3	-416
PSMD11	-307
PSME3	-153
RNF185	257
ERLEC1	432
PSMB5	486
PSMD12	1198
ERLIN1	3183
SEL1L	3218
OS9	3492
PSMD5	4230
PSME4	6251

---

Degradation of DVL

Degradation of DVL

	239
set	Degradation of DVL
setSize	52
pANOVA	3.8e-16
s.dist	-0.653
p.adjustANOVA	5.88e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
RBX1	-3082
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-3224
PSMB6	-3105
RBX1	-3082
PSMA7	-3028
PSMB3	-3012
PSMD8	-3008
PSMB1	-2979
SEM1	-2968
PSMA4	-2929
UBC	-2887
PSMD7	-2885
PSMB7	-2865
PSMB10	-2849
RPS27A	-2821
PSMA2	-2803
PSMA3	-2787
PSMB8	-2753
PSMA5	-2655
PSMB2	-2644
PSMD9	-2638
PSMA1	-2401
PSME2	-2323
PSMD4	-2233
PSME1	-2223
PSMC4	-2206
PSMC1	-2176
PSMD13	-2161
PSMA6	-2159
PSMC3	-2144
PSMC5	-2073
PSMC6	-2047
PSMD1	-2012
PSMD2	-1923
PSMC2	-1899
PSMD6	-1878
PSMD14	-1585
PSMB4	-1579
UBB	-975
PSMD10	-847
PSMB9	-715
PSMF1	-455
PSMD3	-416
PSMD11	-307
PSME3	-153
PSMB5	486
PSMD12	1198
DVL3	2041
DVL2	2265
KLHL12	2360
PSMD5	4230
PSME4	6251
CUL3	7612

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] stringr_1.5.0        harmony_0.1.1        Rcpp_1.0.11         
##  [4] tidyr_1.3.0          SeuratWrappers_0.3.1 SeuratObject_4.1.3  
##  [7] Seurat_4.3.0.1       pkgload_1.3.2.1      GGally_2.1.2        
## [10] ggplot2_3.4.3        reshape2_1.4.4       beeswarm_0.4.0      
## [13] gtools_3.9.4         tibble_3.2.1         dplyr_1.1.3         
## [16] echarts4r_0.4.5      kableExtra_1.3.4     gplots_3.1.3        
## [19] mitch_1.12.0        
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3     rstudioapi_0.15.0      jsonlite_1.8.7        
##   [4] magrittr_2.0.3         spatstat.utils_3.0-3   farver_2.1.1          
##   [7] rmarkdown_2.25         vctrs_0.6.3            ROCR_1.0-11           
##  [10] spatstat.explore_3.2-3 webshot_0.5.5          htmltools_0.5.6       
##  [13] sass_0.4.7             sctransform_0.3.5      parallelly_1.36.0     
##  [16] KernSmooth_2.23-22     bslib_0.5.1            htmlwidgets_1.6.2     
##  [19] ica_1.0-3              plyr_1.8.8             plotly_4.10.2         
##  [22] zoo_1.8-12             cachem_1.0.8           igraph_1.5.1          
##  [25] mime_0.12              lifecycle_1.0.3        pkgconfig_2.0.3       
##  [28] rsvd_1.0.5             Matrix_1.6-1.1         R6_2.5.1              
##  [31] fastmap_1.1.1          fitdistrplus_1.1-11    future_1.33.0         
##  [34] shiny_1.7.5            digest_0.6.33          colorspace_2.1-0      
##  [37] reshape_0.8.9          patchwork_1.1.3        tensor_1.5            
##  [40] irlba_2.3.5.1          labeling_0.4.3         progressr_0.14.0      
##  [43] fansi_1.0.4            spatstat.sparse_3.0-2  httr_1.4.7            
##  [46] polyclip_1.10-4        abind_1.4-5            compiler_4.3.1        
##  [49] remotes_2.4.2.1        withr_2.5.0            highr_0.10            
##  [52] R.utils_2.12.2         MASS_7.3-60            caTools_1.18.2        
##  [55] tools_4.3.1            lmtest_0.9-40          httpuv_1.6.11         
##  [58] future.apply_1.11.0    goftest_1.2-3          R.oo_1.25.0           
##  [61] glue_1.6.2             nlme_3.1-163           promises_1.2.1        
##  [64] grid_4.3.1             Rtsne_0.16             cluster_2.1.4         
##  [67] generics_0.1.3         gtable_0.3.4           spatstat.data_3.0-1   
##  [70] R.methodsS3_1.8.2      data.table_1.14.8      sp_2.0-0              
##  [73] xml2_1.3.5             utf8_1.2.3             spatstat.geom_3.2-5   
##  [76] RcppAnnoy_0.0.21       ggrepel_0.9.3          RANN_2.6.1            
##  [79] pillar_1.9.0           later_1.3.1            splines_4.3.1         
##  [82] lattice_0.21-8         survival_3.5-7         deldir_1.0-9          
##  [85] tidyselect_1.2.0       miniUI_0.1.1.1         pbapply_1.7-2         
##  [88] knitr_1.44             gridExtra_2.3          svglite_2.1.1         
##  [91] scattermore_1.2        xfun_0.40              matrixStats_1.0.0     
##  [94] stringi_1.7.12         lazyeval_0.2.2         yaml_2.3.7            
##  [97] evaluate_0.21          codetools_0.2-19       BiocManager_1.30.22   
## [100] cli_3.6.1              uwot_0.1.16            xtable_1.8-4          
## [103] reticulate_1.32.0      systemfonts_1.0.4      munsell_0.5.0         
## [106] jquerylib_0.1.4        globals_0.16.2         spatstat.random_3.1-6 
## [109] png_0.1-8              parallel_4.3.1         ellipsis_0.3.2        
## [112] bitops_1.0-7           listenv_0.9.0          viridisLite_0.4.2     
## [115] scales_1.2.1           ggridges_0.5.4         leiden_0.4.3          
## [118] purrr_1.0.2            rlang_1.1.1            cowplot_1.1.1         
## [121] rvest_1.0.3

END of report