date generated: 2023-09-22

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
FTL 221.2190
RPS9 -275.2852
CST3 -275.2852
env 221.2190
gag 221.2190
pol 221.2190

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2630
num_genes_in_profile 10703
duplicated_genes_present 0
num_profile_genes_in_sets 6209
num_profile_genes_not_in_sets 4494

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-20.gmt
Gene set metrics
Gene sets metrics
num_genesets 2630
num_genesets_excluded 1333
num_genesets_included 1297

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
Eukaryotic Translation Elongation 90 1.07e-35 -0.760 3.48e-33
Peptide chain elongation 87 2.36e-34 -0.757 6.12e-32
Viral mRNA Translation 87 3.78e-33 -0.743 5.45e-31
Formation of a pool of free 40S subunits 98 3.72e-36 -0.733 2.38e-33
Translocation of ZAP-70 to Immunological synapse 10 6.39e-05 -0.730 1.12e-03
SARS-CoV-1 modulates host translation machinery 36 7.29e-14 -0.720 2.56e-12
L13a-mediated translational silencing of Ceruloplasmin expression 108 5.42e-36 -0.697 2.38e-33
GTP hydrolysis and joining of the 60S ribosomal subunit 109 5.51e-36 -0.694 2.38e-33
Selenocysteine synthesis 90 3.05e-29 -0.684 3.60e-27
SRP-dependent cotranslational protein targeting to membrane 109 6.35e-34 -0.673 1.37e-31
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 3.83e-29 -0.672 4.14e-27
Gap junction assembly 10 2.99e-04 -0.660 4.22e-03
Transport of connexons to the plasma membrane 10 2.99e-04 -0.660 4.22e-03
Eukaryotic Translation Termination 91 1.57e-27 -0.659 1.56e-25
Response of EIF2AK4 (GCN2) to amino acid deficiency 98 2.97e-29 -0.656 3.60e-27
Generation of second messenger molecules 18 1.55e-06 -0.654 3.41e-05
Cap-dependent Translation Initiation 116 1.66e-33 -0.648 2.69e-31
Eukaryotic Translation Initiation 116 1.66e-33 -0.648 2.69e-31
Formation of the ternary complex, and subsequently, the 43S complex 50 7.22e-15 -0.636 2.84e-13
Phosphorylation of CD3 and TCR zeta chains 14 5.50e-05 -0.623 9.91e-04
Translation initiation complex formation 57 6.54e-16 -0.619 2.92e-14
Ribosomal scanning and start codon recognition 57 7.37e-16 -0.617 3.19e-14
Chaperone Mediated Autophagy 18 6.15e-06 -0.616 1.31e-04
Selenoamino acid metabolism 101 1.01e-25 -0.604 8.23e-24
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 58 5.09e-15 -0.594 2.06e-13
FASTK family proteins regulate processing and stability of mitochondrial RNAs 17 3.61e-05 -0.579 6.70e-04
Chemokine receptors bind chemokines 10 1.61e-03 0.576 1.75e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 1.13e-25 -0.571 8.23e-24
Nonsense-Mediated Decay (NMD) 113 1.13e-25 -0.571 8.23e-24
Post-chaperonin tubulin folding pathway 14 3.96e-04 -0.547 5.41e-03
NOTCH2 Activation and Transmission of Signal to the Nucleus 16 2.57e-04 -0.528 3.78e-03
tRNA processing in the mitochondrion 18 1.10e-04 -0.526 1.86e-03
Influenza Viral RNA Transcription and Replication 133 1.14e-25 -0.526 8.23e-24
Formation of ATP by chemiosmotic coupling 18 1.69e-04 -0.512 2.68e-03
Influenza Infection 152 1.13e-26 -0.503 1.05e-24
SARS-CoV-2 modulates host translation machinery 47 2.55e-09 -0.503 7.52e-08
PD-1 signaling 14 1.41e-03 -0.493 1.58e-02
Gap junction trafficking 19 2.08e-04 -0.492 3.15e-03
Mitochondrial RNA degradation 23 6.15e-05 -0.483 1.09e-03
mRNA decay by 3’ to 5’ exoribonuclease 13 2.64e-03 0.482 2.59e-02
TICAM1,TRAF6-dependent induction of TAK1 complex 10 8.56e-03 -0.480 6.38e-02
Plasma lipoprotein assembly 11 6.37e-03 -0.475 5.33e-02
Negative regulation of FLT3 11 6.55e-03 -0.474 5.39e-02
TICAM1-dependent activation of IRF3/IRF7 11 6.65e-03 -0.473 5.39e-02
APOBEC3G mediated resistance to HIV-1 infection 10 1.00e-02 0.470 7.11e-02
Gap junction trafficking and regulation 21 2.28e-04 -0.465 3.39e-03
NF-kB is activated and signals survival 11 1.00e-02 -0.448 7.11e-02
Amyloid fiber formation 32 1.36e-05 -0.444 2.76e-04
Metabolism of folate and pterines 14 4.20e-03 0.442 3.73e-02
NGF-stimulated transcription 25 1.57e-04 -0.437 2.51e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Eukaryotic Translation Elongation 90 1.07e-35 -0.760000 3.48e-33
Peptide chain elongation 87 2.36e-34 -0.757000 6.12e-32
Viral mRNA Translation 87 3.78e-33 -0.743000 5.45e-31
Formation of a pool of free 40S subunits 98 3.72e-36 -0.733000 2.38e-33
Translocation of ZAP-70 to Immunological synapse 10 6.39e-05 -0.730000 1.12e-03
SARS-CoV-1 modulates host translation machinery 36 7.29e-14 -0.720000 2.56e-12
L13a-mediated translational silencing of Ceruloplasmin expression 108 5.42e-36 -0.697000 2.38e-33
GTP hydrolysis and joining of the 60S ribosomal subunit 109 5.51e-36 -0.694000 2.38e-33
Selenocysteine synthesis 90 3.05e-29 -0.684000 3.60e-27
SRP-dependent cotranslational protein targeting to membrane 109 6.35e-34 -0.673000 1.37e-31
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 3.83e-29 -0.672000 4.14e-27
Gap junction assembly 10 2.99e-04 -0.660000 4.22e-03
Transport of connexons to the plasma membrane 10 2.99e-04 -0.660000 4.22e-03
Eukaryotic Translation Termination 91 1.57e-27 -0.659000 1.56e-25
Response of EIF2AK4 (GCN2) to amino acid deficiency 98 2.97e-29 -0.656000 3.60e-27
Generation of second messenger molecules 18 1.55e-06 -0.654000 3.41e-05
Cap-dependent Translation Initiation 116 1.66e-33 -0.648000 2.69e-31
Eukaryotic Translation Initiation 116 1.66e-33 -0.648000 2.69e-31
Formation of the ternary complex, and subsequently, the 43S complex 50 7.22e-15 -0.636000 2.84e-13
Phosphorylation of CD3 and TCR zeta chains 14 5.50e-05 -0.623000 9.91e-04
Translation initiation complex formation 57 6.54e-16 -0.619000 2.92e-14
Ribosomal scanning and start codon recognition 57 7.37e-16 -0.617000 3.19e-14
Chaperone Mediated Autophagy 18 6.15e-06 -0.616000 1.31e-04
Selenoamino acid metabolism 101 1.01e-25 -0.604000 8.23e-24
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 58 5.09e-15 -0.594000 2.06e-13
FASTK family proteins regulate processing and stability of mitochondrial RNAs 17 3.61e-05 -0.579000 6.70e-04
Chemokine receptors bind chemokines 10 1.61e-03 0.576000 1.75e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 1.13e-25 -0.571000 8.23e-24
Nonsense-Mediated Decay (NMD) 113 1.13e-25 -0.571000 8.23e-24
Post-chaperonin tubulin folding pathway 14 3.96e-04 -0.547000 5.41e-03
NOTCH2 Activation and Transmission of Signal to the Nucleus 16 2.57e-04 -0.528000 3.78e-03
tRNA processing in the mitochondrion 18 1.10e-04 -0.526000 1.86e-03
Influenza Viral RNA Transcription and Replication 133 1.14e-25 -0.526000 8.23e-24
Formation of ATP by chemiosmotic coupling 18 1.69e-04 -0.512000 2.68e-03
Influenza Infection 152 1.13e-26 -0.503000 1.05e-24
SARS-CoV-2 modulates host translation machinery 47 2.55e-09 -0.503000 7.52e-08
PD-1 signaling 14 1.41e-03 -0.493000 1.58e-02
Gap junction trafficking 19 2.08e-04 -0.492000 3.15e-03
Mitochondrial RNA degradation 23 6.15e-05 -0.483000 1.09e-03
mRNA decay by 3’ to 5’ exoribonuclease 13 2.64e-03 0.482000 2.59e-02
TICAM1,TRAF6-dependent induction of TAK1 complex 10 8.56e-03 -0.480000 6.38e-02
Plasma lipoprotein assembly 11 6.37e-03 -0.475000 5.33e-02
Negative regulation of FLT3 11 6.55e-03 -0.474000 5.39e-02
TICAM1-dependent activation of IRF3/IRF7 11 6.65e-03 -0.473000 5.39e-02
APOBEC3G mediated resistance to HIV-1 infection 10 1.00e-02 0.470000 7.11e-02
Gap junction trafficking and regulation 21 2.28e-04 -0.465000 3.39e-03
NF-kB is activated and signals survival 11 1.00e-02 -0.448000 7.11e-02
Amyloid fiber formation 32 1.36e-05 -0.444000 2.76e-04
Metabolism of folate and pterines 14 4.20e-03 0.442000 3.73e-02
NGF-stimulated transcription 25 1.57e-04 -0.437000 2.51e-03
InlB-mediated entry of Listeria monocytogenes into host cell 12 9.72e-03 -0.431000 7.05e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus 18 1.63e-03 -0.429000 1.76e-02
Alpha-protein kinase 1 signaling pathway 11 1.50e-02 -0.423000 9.85e-02
2-LTR circle formation 12 1.21e-02 0.419000 8.12e-02
Downregulation of ERBB2 signaling 18 2.15e-03 -0.418000 2.18e-02
RHO GTPases Activate NADPH Oxidases 19 1.69e-03 -0.416000 1.81e-02
Negative regulation of MET activity 16 4.06e-03 -0.415000 3.63e-02
Formation of tubulin folding intermediates by CCT/TriC 17 3.10e-03 -0.414000 2.92e-02
Other semaphorin interactions 11 1.75e-02 -0.414000 1.07e-01
Signaling by NOTCH2 24 4.54e-04 -0.414000 6.14e-03
Interferon alpha/beta signaling 55 1.19e-07 -0.413000 3.09e-06
Processing and activation of SUMO 10 2.49e-02 0.410000 1.41e-01
Binding and entry of HIV virion 11 1.94e-02 0.407000 1.16e-01
EPH-ephrin mediated repulsion of cells 27 2.70e-04 -0.405000 3.90e-03
Infection with Mycobacterium tuberculosis 24 6.04e-04 -0.405000 7.68e-03
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 2.79e-02 -0.402000 1.52e-01
p75NTR recruits signalling complexes 11 2.14e-02 -0.401000 1.26e-01
RHOBTB GTPase Cycle 33 7.26e-05 -0.399000 1.25e-03
Ephrin signaling 13 1.28e-02 -0.399000 8.48e-02
Pexophagy 10 2.90e-02 -0.399000 1.55e-01
Cellular response to starvation 143 2.25e-16 -0.398000 1.12e-14
HDMs demethylate histones 21 1.76e-03 -0.394000 1.86e-02
Antimicrobial peptides 15 8.21e-03 -0.394000 6.23e-02
p75NTR signals via NF-kB 14 1.09e-02 -0.393000 7.55e-02
SARS-CoV-1-host interactions 88 2.50e-10 -0.391000 7.54e-09
Sema4D in semaphorin signaling 16 6.92e-03 -0.390000 5.48e-02
Attachment and Entry 9694614 10 3.28e-02 -0.390000 1.69e-01
NRIF signals cell death from the nucleus 14 1.18e-02 -0.389000 8.03e-02
RHOBTB2 GTPase cycle 22 1.72e-03 -0.386000 1.83e-02
Regulation of expression of SLITs and ROBOs 154 2.05e-16 -0.385000 1.06e-14
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 11 2.77e-02 -0.383000 1.52e-01
Cell-extracellular matrix interactions 13 1.69e-02 -0.383000 1.05e-01
RHOBTB1 GTPase cycle 21 2.48e-03 -0.381000 2.48e-02
Recycling pathway of L1 32 2.03e-04 -0.380000 3.14e-03
Signaling by ROBO receptors 184 4.05e-18 -0.372000 2.39e-16
Complement cascade 18 6.92e-03 -0.368000 5.48e-02
Response of Mtb to phagocytosis 21 3.68e-03 -0.366000 3.39e-02
GPVI-mediated activation cascade 27 1.05e-03 -0.365000 1.24e-02
Cell death signalling via NRAGE, NRIF and NADE 52 6.25e-06 -0.362000 1.31e-04
IRAK2 mediated activation of TAK1 complex 10 4.73e-02 -0.362000 2.01e-01
Glycogen storage diseases 11 3.77e-02 -0.362000 1.77e-01
RHO GTPases activate IQGAPs 22 3.33e-03 -0.362000 3.08e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 24 2.27e-03 -0.360000 2.28e-02
Suppression of phagosomal maturation 12 3.13e-02 -0.359000 1.64e-01
Major pathway of rRNA processing in the nucleolus and cytosol 172 6.08e-16 -0.358000 2.85e-14
Sema4D induced cell migration and growth-cone collapse 13 2.59e-02 -0.357000 1.44e-01
Listeria monocytogenes entry into host cells 17 1.09e-02 -0.357000 7.55e-02
Semaphorin interactions 44 4.60e-05 -0.355000 8.41e-04
APC truncation mutants have impaired AXIN binding 12 3.69e-02 0.348000 1.75e-01
AXIN missense mutants destabilize the destruction complex 12 3.69e-02 0.348000 1.75e-01
Signaling by AMER1 mutants 12 3.69e-02 0.348000 1.75e-01
Signaling by APC mutants 12 3.69e-02 0.348000 1.75e-01
Signaling by AXIN mutants 12 3.69e-02 0.348000 1.75e-01
Truncations of AMER1 destabilize the destruction complex 12 3.69e-02 0.348000 1.75e-01
Aggrephagy 30 9.89e-04 -0.348000 1.21e-02
Activation of AMPK downstream of NMDARs 16 1.62e-02 -0.347000 1.01e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.73e-02 -0.346000 2.01e-01
Prefoldin mediated transfer of substrate to CCT/TriC 23 4.97e-03 -0.339000 4.27e-02
VLDLR internalisation and degradation 14 2.91e-02 -0.337000 1.55e-01
Signaling by CSF1 (M-CSF) in myeloid cells 28 2.09e-03 -0.336000 2.13e-02
Regulation of BACH1 activity 11 5.46e-02 -0.335000 2.25e-01
Caspase-mediated cleavage of cytoskeletal proteins 10 6.82e-02 -0.333000 2.56e-01
Signaling by NOTCH3 33 1.06e-03 -0.330000 1.24e-02
rRNA processing 203 1.04e-15 -0.328000 4.34e-14
rRNA processing in the mitochondrion 21 9.47e-03 -0.327000 6.90e-02
rRNA processing in the nucleus and cytosol 182 3.63e-14 -0.327000 1.35e-12
Integration of provirus 14 3.55e-02 0.325000 1.75e-01
DAP12 signaling 22 8.54e-03 -0.324000 6.38e-02
PINK1-PRKN Mediated Mitophagy 21 1.09e-02 -0.321000 7.55e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity 29 2.88e-03 -0.320000 2.74e-02
G alpha (12/13) signalling events 45 2.09e-04 -0.320000 3.15e-03
NRAGE signals death through JNK 35 1.13e-03 -0.318000 1.31e-02
Interconversion of nucleotide di- and triphosphates 24 7.30e-03 0.317000 5.65e-02
Interleukin-2 family signaling 30 2.77e-03 -0.316000 2.66e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 10 8.44e-02 -0.315000 2.90e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 10 8.44e-02 -0.315000 2.90e-01
Bacterial Infection Pathways 52 9.02e-05 -0.314000 1.54e-03
Inactivation, recovery and regulation of the phototransduction cascade 16 2.99e-02 0.314000 1.59e-01
Regulation of innate immune responses to cytosolic DNA 11 7.26e-02 -0.313000 2.66e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 18 2.22e-02 0.312000 1.28e-01
Activated NOTCH1 Transmits Signal to the Nucleus 22 1.15e-02 -0.311000 7.84e-02
Apoptotic cleavage of cellular proteins 25 7.18e-03 -0.311000 5.61e-02
Interleukin-15 signaling 11 7.53e-02 -0.310000 2.70e-01
VEGFR2 mediated cell proliferation 15 3.86e-02 0.309000 1.80e-01
EPHA-mediated growth cone collapse 10 9.26e-02 -0.307000 3.07e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 33 2.60e-03 -0.303000 2.57e-02
Nuclear events stimulated by ALK signaling in cancer 19 2.24e-02 -0.303000 1.28e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 16 3.67e-02 -0.302000 1.75e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 16 3.67e-02 -0.302000 1.75e-01
Purine catabolism 13 6.08e-02 -0.300000 2.41e-01
MHC class II antigen presentation 90 8.83e-07 -0.300000 2.01e-05
Uptake and actions of bacterial toxins 16 3.77e-02 -0.300000 1.77e-01
DAP12 interactions 28 6.07e-03 -0.300000 5.15e-02
The NLRP3 inflammasome 15 4.52e-02 -0.299000 1.98e-01
TICAM1, RIP1-mediated IKK complex recruitment 18 2.87e-02 -0.298000 1.54e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 38 1.51e-03 -0.298000 1.66e-02
Regulation of TP53 Activity through Methylation 19 2.49e-02 -0.297000 1.41e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 41 1.03e-03 -0.296000 1.24e-02
M-decay: degradation of maternal mRNAs by maternally stored factors 37 1.88e-03 -0.296000 1.93e-02
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 47 4.79e-04 -0.295000 6.41e-03
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 12 7.75e-02 -0.294000 2.75e-01
Regulation of Complement cascade 16 4.19e-02 -0.294000 1.87e-01
FOXO-mediated transcription of cell death genes 14 5.75e-02 -0.293000 2.32e-01
The phototransduction cascade 17 3.69e-02 0.292000 1.75e-01
p38MAPK events 11 9.68e-02 0.289000 3.13e-01
Axon guidance 350 4.54e-20 -0.287000 2.94e-18
Sensory processing of sound 29 7.46e-03 -0.287000 5.73e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 59 1.45e-04 -0.286000 2.42e-03
Inactivation of CSF3 (G-CSF) signaling 23 1.77e-02 -0.286000 1.08e-01
Interferon gamma signaling 71 3.33e-05 -0.285000 6.26e-04
Diseases of carbohydrate metabolism 24 1.57e-02 -0.285000 1.01e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 4.66e-03 -0.285000 4.03e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 4.26e-02 0.284000 1.89e-01
Deadenylation of mRNA 21 2.46e-02 -0.283000 1.41e-01
EPH-Ephrin signaling 60 1.55e-04 -0.283000 2.51e-03
Depolymerization of the Nuclear Lamina 12 9.05e-02 0.282000 3.04e-01
Nervous system development 362 1.03e-19 -0.280000 6.38e-18
KSRP (KHSRP) binds and destabilizes mRNA 16 5.30e-02 0.279000 2.20e-01
Telomere C-strand synthesis initiation 13 8.14e-02 0.279000 2.85e-01
EGFR downregulation 20 3.09e-02 -0.279000 1.63e-01
Constitutive Signaling by Aberrant PI3K in Cancer 25 1.62e-02 -0.278000 1.01e-01
FCGR3A-mediated phagocytosis 52 5.35e-04 -0.278000 6.87e-03
Leishmania phagocytosis 52 5.35e-04 -0.278000 6.87e-03
Parasite infection 52 5.35e-04 -0.278000 6.87e-03
Inhibition of replication initiation of damaged DNA by RB1/E2F1 11 1.13e-01 0.276000 3.39e-01
Growth hormone receptor signaling 14 7.40e-02 -0.276000 2.70e-01
FCERI mediated Ca+2 mobilization 23 2.22e-02 -0.276000 1.28e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 11 1.14e-01 -0.276000 3.39e-01
SARS-CoV-1 Infection 131 5.95e-08 -0.275000 1.57e-06
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 16 5.70e-02 -0.275000 2.30e-01
Translation 265 2.94e-14 -0.273000 1.12e-12
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 17 5.18e-02 -0.273000 2.17e-01
Nuclear signaling by ERBB4 18 4.54e-02 -0.272000 1.98e-01
Regulation of actin dynamics for phagocytic cup formation 55 4.92e-04 -0.272000 6.52e-03
Diseases associated with glycosylation precursor biosynthesis 15 6.85e-02 0.272000 2.56e-01
Cristae formation 31 8.93e-03 -0.272000 6.62e-02
Calnexin/calreticulin cycle 25 1.91e-02 -0.271000 1.15e-01
RHO GTPases Activate WASPs and WAVEs 34 6.56e-03 -0.270000 5.39e-02
Metabolism of cofactors 16 6.29e-02 0.269000 2.45e-01
RAC1 GTPase cycle 130 1.81e-07 -0.266000 4.59e-06
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 7.54e-02 -0.265000 2.70e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 15 7.54e-02 -0.265000 2.70e-01
CTNNB1 S33 mutants aren’t phosphorylated 13 9.88e-02 0.264000 3.13e-01
CTNNB1 S37 mutants aren’t phosphorylated 13 9.88e-02 0.264000 3.13e-01
CTNNB1 S45 mutants aren’t phosphorylated 13 9.88e-02 0.264000 3.13e-01
CTNNB1 T41 mutants aren’t phosphorylated 13 9.88e-02 0.264000 3.13e-01
Signaling by CTNNB1 phospho-site mutants 13 9.88e-02 0.264000 3.13e-01
Signaling by GSK3beta mutants 13 9.88e-02 0.264000 3.13e-01
Synthesis of PA 22 3.32e-02 0.262000 1.70e-01
EPHB-mediated forward signaling 33 9.33e-03 -0.262000 6.84e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 28 1.68e-02 -0.261000 1.04e-01
E2F mediated regulation of DNA replication 17 6.26e-02 0.261000 2.45e-01
ALK mutants bind TKIs 12 1.18e-01 -0.260000 3.46e-01
Sensory processing of sound by outer hair cells of the cochlea 22 3.67e-02 -0.257000 1.75e-01
Assembly and cell surface presentation of NMDA receptors 20 4.64e-02 -0.257000 2.01e-01
L1CAM interactions 59 6.45e-04 -0.257000 8.12e-03
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 12 1.26e-01 -0.255000 3.53e-01
Regulation of NF-kappa B signaling 17 6.87e-02 -0.255000 2.56e-01
SARS-CoV-2-host interactions 169 1.27e-08 -0.255000 3.59e-07
Inactivation of APC/C via direct inhibition of the APC/C complex 16 7.91e-02 0.254000 2.79e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 16 7.91e-02 0.254000 2.79e-01
Signaling by Erythropoietin 23 3.59e-02 -0.253000 1.75e-01
Plasma lipoprotein clearance 28 2.07e-02 -0.253000 1.23e-01
p75 NTR receptor-mediated signalling 70 2.70e-04 -0.252000 3.90e-03
Regulation of signaling by CBL 21 4.58e-02 -0.252000 1.99e-01
Transcriptional regulation of granulopoiesis 22 4.22e-02 -0.250000 1.87e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 17 7.49e-02 0.250000 2.70e-01
TP53 Regulates Transcription of Cell Death Genes 36 9.80e-03 0.249000 7.06e-02
NOTCH3 Intracellular Domain Regulates Transcription 16 8.48e-02 -0.249000 2.91e-01
Sensory processing of sound by inner hair cells of the cochlea 27 2.55e-02 -0.248000 1.43e-01
B-WICH complex positively regulates rRNA expression 25 3.36e-02 -0.246000 1.72e-01
Signaling by ERBB2 35 1.21e-02 -0.245000 8.12e-02
Signaling by ALK fusions and activated point mutants 50 2.75e-03 -0.245000 2.66e-02
Signaling by ALK in cancer 50 2.75e-03 -0.245000 2.66e-02
CDC42 GTPase cycle 107 1.32e-05 -0.244000 2.73e-04
Interleukin receptor SHC signaling 18 7.46e-02 -0.243000 2.70e-01
Beta-catenin phosphorylation cascade 14 1.16e-01 0.242000 3.45e-01
Phosphorylation of the APC/C 16 9.34e-02 0.242000 3.08e-01
Fcgamma receptor (FCGR) dependent phagocytosis 73 3.77e-04 -0.241000 5.20e-03
Caspase activation via Death Receptors in the presence of ligand 14 1.19e-01 0.240000 3.46e-01
Apoptotic execution phase 32 1.92e-02 -0.239000 1.15e-01
RHO GTPases activate CIT 12 1.53e-01 -0.238000 3.93e-01
Signaling by cytosolic FGFR1 fusion mutants 17 9.06e-02 -0.237000 3.04e-01
IKK complex recruitment mediated by RIP1 22 5.46e-02 -0.237000 2.25e-01
Selective autophagy 65 1.08e-03 -0.235000 1.26e-02
Diseases associated with the TLR signaling cascade 26 3.92e-02 -0.234000 1.80e-01
Diseases of Immune System 26 3.92e-02 -0.234000 1.80e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.06e-01 -0.234000 3.24e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 2.01e-01 -0.233000 4.66e-01
FGFR1 mutant receptor activation 20 7.14e-02 -0.233000 2.65e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 16 1.07e-01 -0.233000 3.26e-01
SARS-CoV-1 activates/modulates innate immune responses 36 1.59e-02 -0.232000 1.01e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 8.79e-02 0.232000 2.98e-01
Attenuation phase 19 8.03e-02 -0.232000 2.82e-01
Retrograde transport at the Trans-Golgi-Network 48 5.52e-03 0.232000 4.71e-02
Role of LAT2/NTAL/LAB on calcium mobilization 14 1.35e-01 -0.231000 3.66e-01
NR1H2 and NR1H3-mediated signaling 37 1.56e-02 -0.230000 1.01e-01
Post NMDA receptor activation events 46 7.18e-03 -0.229000 5.61e-02
Neutrophil degranulation 377 3.90e-14 -0.229000 1.40e-12
Polymerase switching on the C-strand of the telomere 22 6.37e-02 0.228000 2.45e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.03e-01 0.228000 3.19e-01
Signaling by CSF3 (G-CSF) 28 3.72e-02 -0.228000 1.75e-01
Developmental Biology 581 2.39e-20 -0.227000 1.63e-18
N-Glycan antennae elongation 10 2.15e-01 0.227000 4.77e-01
Signaling by EGFR in Cancer 17 1.07e-01 -0.226000 3.25e-01
Synthesis of IP3 and IP4 in the cytosol 13 1.59e-01 -0.226000 4.01e-01
Signaling by BMP 15 1.30e-01 -0.226000 3.59e-01
Formation of Fibrin Clot (Clotting Cascade) 10 2.19e-01 -0.225000 4.82e-01
Josephin domain DUBs 10 2.20e-01 -0.224000 4.84e-01
Formation of the cornified envelope 14 1.47e-01 0.224000 3.85e-01
Keratinization 14 1.47e-01 0.224000 3.85e-01
Retinoid metabolism and transport 18 1.01e-01 -0.223000 3.16e-01
Late endosomal microautophagy 30 3.49e-02 -0.223000 1.75e-01
Regulation of KIT signaling 12 1.83e-01 -0.222000 4.39e-01
RAF-independent MAPK1/3 activation 18 1.04e-01 -0.221000 3.20e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 123 2.45e-05 -0.221000 4.75e-04
Role of phospholipids in phagocytosis 17 1.18e-01 -0.219000 3.46e-01
Diseases associated with N-glycosylation of proteins 20 9.29e-02 0.217000 3.07e-01
Mitophagy 28 4.72e-02 -0.217000 2.01e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 16 1.34e-01 -0.217000 3.64e-01
Neurodegenerative Diseases 16 1.34e-01 -0.217000 3.64e-01
Metabolism of polyamines 54 6.25e-03 0.215000 5.27e-02
Assembly of collagen fibrils and other multimeric structures 17 1.25e-01 -0.215000 3.52e-01
Metabolism of steroid hormones 16 1.37e-01 0.215000 3.67e-01
Sphingolipid de novo biosynthesis 25 6.36e-02 0.214000 2.45e-01
Cleavage of the damaged pyrimidine 14 1.65e-01 0.214000 4.14e-01
Depyrimidination 14 1.65e-01 0.214000 4.14e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 14 1.65e-01 0.214000 4.14e-01
RHO GTPase cycle 321 5.73e-11 -0.214000 1.81e-09
Signaling by TGFB family members 84 7.10e-04 -0.214000 8.86e-03
Sealing of the nuclear envelope (NE) by ESCRT-III 22 8.24e-02 -0.214000 2.87e-01
Regulation of CDH11 Expression and Function 14 1.66e-01 -0.214000 4.14e-01
MyD88 deficiency (TLR2/4) 14 1.67e-01 -0.214000 4.14e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 16 1.42e-01 -0.212000 3.76e-01
Regulation of TP53 Expression and Degradation 34 3.29e-02 -0.212000 1.69e-01
Platelet degranulation 73 1.81e-03 -0.212000 1.88e-02
Regulation of Expression and Function of Type II Classical Cadherins 15 1.58e-01 -0.211000 3.99e-01
Regulation of Homotypic Cell-Cell Adhesion 15 1.58e-01 -0.211000 3.99e-01
Nuclear Events (kinase and transcription factor activation) 44 1.58e-02 -0.211000 1.01e-01
O-linked glycosylation 37 2.68e-02 0.211000 1.48e-01
Maternal to zygotic transition (MZT) 50 1.01e-02 -0.210000 7.15e-02
Signaling by TGF-beta Receptor Complex 74 1.79e-03 -0.210000 1.87e-02
Amino acid transport across the plasma membrane 18 1.23e-01 -0.210000 3.50e-01
Ras activation upon Ca2+ influx through NMDA receptor 10 2.50e-01 0.210000 5.16e-01
Glycogen synthesis 10 2.51e-01 -0.210000 5.16e-01
Carboxyterminal post-translational modifications of tubulin 21 9.75e-02 -0.209000 3.13e-01
Activation of the pre-replicative complex 19 1.17e-01 0.208000 3.46e-01
Negative regulation of FGFR1 signaling 19 1.20e-01 -0.206000 3.47e-01
Keratan sulfate biosynthesis 13 1.98e-01 0.206000 4.63e-01
SARS-CoV Infections 344 7.47e-11 -0.206000 2.31e-09
Signaling by ERBB4 33 4.10e-02 -0.206000 1.83e-01
Deactivation of the beta-catenin transactivating complex 29 5.70e-02 -0.204000 2.30e-01
Detoxification of Reactive Oxygen Species 27 6.72e-02 -0.204000 2.55e-01
mRNA 3’-end processing 55 9.30e-03 -0.203000 6.84e-02
Plasma lipoprotein assembly, remodeling, and clearance 46 1.81e-02 -0.202000 1.09e-01
Regulation of TP53 Degradation 33 4.55e-02 -0.201000 1.98e-01
Leading Strand Synthesis 13 2.09e-01 0.201000 4.74e-01
Polymerase switching 13 2.09e-01 0.201000 4.74e-01
Interferon Signaling 207 7.01e-07 -0.201000 1.62e-05
TP53 Regulates Transcription of Cell Cycle Genes 35 3.99e-02 -0.201000 1.80e-01
Metabolism of fat-soluble vitamins 21 1.11e-01 -0.201000 3.37e-01
Negative regulators of DDX58/IFIH1 signaling 34 4.31e-02 -0.201000 1.90e-01
Translation of Structural Proteins 9683701 29 6.22e-02 -0.200000 2.44e-01
Formation of apoptosome 10 2.73e-01 0.200000 5.39e-01
Regulation of the apoptosome activity 10 2.73e-01 0.200000 5.39e-01
HSF1 activation 23 9.70e-02 -0.200000 3.13e-01
LDL clearance 15 1.81e-01 -0.200000 4.39e-01
Cytosolic sensors of pathogen-associated DNA 56 9.95e-03 -0.199000 7.11e-02
Downregulation of TGF-beta receptor signaling 24 9.14e-02 -0.199000 3.05e-01
Sema3A PAK dependent Axon repulsion 14 2.00e-01 -0.198000 4.66e-01
Platelet sensitization by LDL 14 2.01e-01 0.197000 4.66e-01
Peptide ligand-binding receptors 29 6.78e-02 0.196000 2.56e-01
Membrane binding and targetting of GAG proteins 14 2.08e-01 -0.194000 4.74e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 2.08e-01 -0.194000 4.74e-01
Heme biosynthesis 12 2.46e-01 0.194000 5.12e-01
Adherens junctions interactions 24 1.03e-01 -0.192000 3.19e-01
The role of Nef in HIV-1 replication and disease pathogenesis 24 1.04e-01 -0.192000 3.20e-01
HS-GAG degradation 13 2.34e-01 -0.191000 4.98e-01
SHC1 events in ERBB2 signaling 11 2.74e-01 0.190000 5.39e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 64 8.56e-03 0.190000 6.38e-02
Inflammasomes 19 1.52e-01 -0.190000 3.91e-01
Response to elevated platelet cytosolic Ca2+ 77 4.01e-03 -0.190000 3.61e-02
Ovarian tumor domain proteases 33 5.92e-02 -0.190000 2.36e-01
RHOU GTPase cycle 34 5.56e-02 -0.190000 2.27e-01
Potential therapeutics for SARS 82 3.05e-03 -0.190000 2.89e-02
SARS-CoV-2 Infection 245 3.76e-07 -0.189000 9.20e-06
SARS-CoV-2 activates/modulates innate and adaptive immune responses 99 1.16e-03 -0.189000 1.33e-02
RAC2 GTPase cycle 69 6.63e-03 -0.189000 5.39e-02
Early Phase of HIV Life Cycle 21 1.34e-01 0.189000 3.64e-01
RNA Polymerase III Abortive And Retractive Initiation 37 4.71e-02 0.189000 2.01e-01
RNA Polymerase III Transcription 37 4.71e-02 0.189000 2.01e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 28 8.40e-02 0.189000 2.90e-01
Signaling by WNT in cancer 18 1.66e-01 0.189000 4.14e-01
HSF1-dependent transactivation 26 9.72e-02 -0.188000 3.13e-01
Defective Intrinsic Pathway for Apoptosis 19 1.57e-01 -0.188000 3.99e-01
Cytochrome c-mediated apoptotic response 12 2.64e-01 0.186000 5.30e-01
Retrograde neurotrophin signalling 10 3.08e-01 -0.186000 5.72e-01
TRAF3-dependent IRF activation pathway 13 2.46e-01 -0.186000 5.12e-01
FCGR3A-mediated IL10 synthesis 26 1.02e-01 -0.186000 3.16e-01
Circadian Clock 58 1.51e-02 -0.185000 9.86e-02
IRAK1 recruits IKK complex 14 2.32e-01 -0.185000 4.95e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 2.32e-01 -0.185000 4.95e-01
G-protein beta:gamma signalling 23 1.27e-01 -0.184000 3.54e-01
Pre-NOTCH Processing in Golgi 16 2.03e-01 -0.184000 4.68e-01
Carnitine metabolism 11 2.91e-01 0.184000 5.55e-01
CaM pathway 23 1.28e-01 -0.183000 3.56e-01
Calmodulin induced events 23 1.28e-01 -0.183000 3.56e-01
RNA Polymerase III Transcription Initiation 34 6.53e-02 0.183000 2.50e-01
ROS and RNS production in phagocytes 25 1.14e-01 -0.183000 3.39e-01
Collagen degradation 19 1.68e-01 -0.183000 4.17e-01
Peroxisomal lipid metabolism 24 1.23e-01 0.182000 3.50e-01
Respiratory electron transport 103 1.45e-03 -0.182000 1.61e-02
Vitamin B5 (pantothenate) metabolism 13 2.58e-01 0.181000 5.25e-01
FCERI mediated MAPK activation 26 1.11e-01 -0.181000 3.36e-01
FLT3 Signaling 32 7.76e-02 -0.180000 2.75e-01
Signaling by Non-Receptor Tyrosine Kinases 36 6.18e-02 -0.180000 2.43e-01
Signaling by PTK6 36 6.18e-02 -0.180000 2.43e-01
Infectious disease 748 1.89e-16 -0.180000 1.02e-14
CTLA4 inhibitory signaling 16 2.13e-01 0.180000 4.77e-01
Interleukin-4 and Interleukin-13 signaling 61 1.56e-02 -0.179000 1.01e-01
Removal of the Flap Intermediate 13 2.64e-01 0.179000 5.30e-01
Cell junction organization 48 3.23e-02 -0.179000 1.68e-01
COPI-independent Golgi-to-ER retrograde traffic 40 5.06e-02 -0.179000 2.13e-01
Activation of NMDA receptors and postsynaptic events 53 2.50e-02 -0.178000 1.41e-01
Thrombin signalling through proteinase activated receptors (PARs) 19 1.79e-01 -0.178000 4.36e-01
mRNA Splicing - Major Pathway 200 1.59e-05 -0.178000 3.18e-04
Innate Immune System 739 6.15e-16 -0.178000 2.85e-14
RAF activation 31 8.78e-02 0.177000 2.98e-01
Regulation of IFNG signaling 12 2.88e-01 -0.177000 5.52e-01
Lysosome Vesicle Biogenesis 30 9.37e-02 -0.177000 3.08e-01
Signalling to RAS 14 2.53e-01 0.177000 5.17e-01
TRP channels 11 3.11e-01 0.176000 5.78e-01
Oncogene Induced Senescence 27 1.13e-01 -0.176000 3.39e-01
Transport of Mature Transcript to Cytoplasm 78 7.31e-03 -0.176000 5.65e-02
RHOH GTPase cycle 26 1.22e-01 -0.176000 3.50e-01
RHO GTPases Activate ROCKs 16 2.25e-01 -0.175000 4.91e-01
Synthesis of substrates in N-glycan biosythesis 50 3.26e-02 0.175000 1.69e-01
TGF-beta receptor signaling activates SMADs 35 7.40e-02 -0.175000 2.70e-01
Integrin cell surface interactions 31 9.27e-02 -0.175000 3.07e-01
RET signaling 23 1.48e-01 -0.174000 3.86e-01
Antigen processing-Cross presentation 96 3.24e-03 -0.174000 3.03e-02
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 16 2.29e-01 0.174000 4.94e-01
Inositol phosphate metabolism 28 1.12e-01 -0.174000 3.37e-01
Neurotransmitter release cycle 20 1.79e-01 -0.174000 4.36e-01
SUMOylation of immune response proteins 11 3.20e-01 -0.173000 5.84e-01
Regulation of ornithine decarboxylase (ODC) 49 3.61e-02 0.173000 1.75e-01
Biotin transport and metabolism 11 3.20e-01 0.173000 5.84e-01
Viral Infection Pathways 616 5.44e-13 -0.173000 1.86e-11
Activation of ATR in response to replication stress 21 1.72e-01 0.172000 4.24e-01
Metabolism of amino acids and derivatives 264 1.80e-06 -0.172000 3.88e-05
E3 ubiquitin ligases ubiquitinate target proteins 40 6.07e-02 -0.172000 2.41e-01
VxPx cargo-targeting to cilium 17 2.21e-01 0.171000 4.84e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 48 4.02e-02 -0.171000 1.80e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 48 4.02e-02 -0.171000 1.80e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 48 4.02e-02 -0.171000 1.80e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 48 4.02e-02 -0.171000 1.80e-01
Signaling by NOTCH1 in Cancer 48 4.02e-02 -0.171000 1.80e-01
Leishmania infection 119 1.29e-03 -0.171000 1.46e-02
Parasitic Infection Pathways 119 1.29e-03 -0.171000 1.46e-02
HDACs deacetylate histones 32 9.41e-02 -0.171000 3.08e-01
Interleukin-20 family signaling 13 2.86e-01 -0.171000 5.51e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 69 1.44e-02 -0.171000 9.46e-02
Spry regulation of FGF signaling 16 2.37e-01 -0.171000 5.01e-01
Intra-Golgi traffic 39 6.57e-02 0.170000 2.51e-01
Positive epigenetic regulation of rRNA expression 40 6.32e-02 -0.170000 2.45e-01
Platelet activation, signaling and aggregation 163 1.93e-04 -0.170000 3.02e-03
mRNA Splicing 208 2.82e-05 -0.169000 5.38e-04
RNA Polymerase II Transcription Termination 62 2.16e-02 -0.169000 1.26e-01
RAC3 GTPase cycle 69 1.60e-02 -0.168000 1.01e-01
Amino acids regulate mTORC1 45 5.26e-02 0.167000 2.19e-01
Downstream signaling of activated FGFR2 11 3.39e-01 0.166000 5.95e-01
Downstream signaling of activated FGFR3 11 3.39e-01 0.166000 5.95e-01
Downstream signaling of activated FGFR4 11 3.39e-01 0.166000 5.95e-01
Receptor Mediated Mitophagy 11 3.40e-01 0.166000 5.95e-01
Recognition of DNA damage by PCNA-containing replication complex 26 1.44e-01 -0.166000 3.79e-01
RIP-mediated NFkB activation via ZBP1 15 2.69e-01 -0.165000 5.34e-01
TNFR1-induced NF-kappa-B signaling pathway 31 1.14e-01 -0.164000 3.39e-01
RAB geranylgeranylation 46 5.47e-02 0.164000 2.25e-01
Regulation of beta-cell development 16 2.57e-01 -0.164000 5.25e-01
Ca-dependent events 25 1.57e-01 -0.164000 3.99e-01
Degradation of the extracellular matrix 45 5.87e-02 -0.163000 2.36e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 63 2.56e-02 -0.163000 1.43e-01
Signaling by ALK 21 1.98e-01 -0.162000 4.63e-01
Diseases of glycosylation 67 2.18e-02 0.162000 1.27e-01
O-linked glycosylation of mucins 26 1.55e-01 0.161000 3.96e-01
Nephrin family interactions 15 2.81e-01 -0.161000 5.46e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 27 1.52e-01 0.160000 3.91e-01
DNA Replication Pre-Initiation 85 1.15e-02 0.159000 7.84e-02
Pentose phosphate pathway 12 3.41e-01 -0.159000 5.95e-01
Signaling by BRAF and RAF1 fusions 52 4.77e-02 -0.159000 2.02e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 19 2.31e-01 -0.159000 4.95e-01
Meiotic recombination 17 2.58e-01 0.158000 5.25e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 3.88e-01 -0.158000 6.42e-01
Signaling by NOTCH1 58 3.84e-02 -0.157000 1.79e-01
TAK1-dependent IKK and NF-kappa-B activation 38 9.48e-02 -0.157000 3.10e-01
Signaling by Receptor Tyrosine Kinases 329 1.33e-06 -0.156000 2.96e-05
Netrin-1 signaling 21 2.17e-01 0.156000 4.80e-01
Metabolism of water-soluble vitamins and cofactors 86 1.28e-02 0.156000 8.48e-02
Paracetamol ADME 10 3.95e-01 0.155000 6.46e-01
Signaling by Rho GTPases 460 1.71e-08 -0.155000 4.72e-07
NPAS4 regulates expression of target genes 12 3.53e-01 -0.155000 6.06e-01
ER Quality Control Compartment (ERQC) 20 2.31e-01 -0.155000 4.95e-01
Cyclin A/B1/B2 associated events during G2/M transition 15 3.01e-01 0.154000 5.66e-01
RHOA GTPase cycle 100 7.93e-03 -0.154000 6.05e-02
Arachidonic acid metabolism 22 2.13e-01 -0.153000 4.77e-01
Removal of the Flap Intermediate from the C-strand 16 2.89e-01 0.153000 5.53e-01
Telomere C-strand (Lagging Strand) Synthesis 29 1.55e-01 0.153000 3.96e-01
APC/C:Cdc20 mediated degradation of Securin 63 3.69e-02 0.152000 1.75e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 67 3.16e-02 0.152000 1.65e-01
Glucagon-type ligand receptors 10 4.06e-01 0.152000 6.58e-01
Prostacyclin signalling through prostacyclin receptor 10 4.06e-01 0.152000 6.58e-01
Transcriptional Regulation by NPAS4 23 2.09e-01 -0.151000 4.74e-01
Mitochondrial iron-sulfur cluster biogenesis 13 3.45e-01 0.151000 6.00e-01
Regulated proteolysis of p75NTR 10 4.08e-01 -0.151000 6.60e-01
FLT3 signaling in disease 25 1.92e-01 -0.151000 4.58e-01
Processing of Capped Intron-Containing Pre-mRNA 274 2.01e-05 -0.151000 3.94e-04
IRAK4 deficiency (TLR2/4) 15 3.14e-01 -0.150000 5.78e-01
Metabolism of RNA 686 4.47e-11 -0.150000 1.45e-09
G-protein mediated events 35 1.26e-01 -0.150000 3.53e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 18 2.74e-01 -0.149000 5.39e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 16 3.03e-01 0.149000 5.68e-01
Trafficking of AMPA receptors 16 3.03e-01 0.149000 5.68e-01
Cell-Cell communication 73 2.85e-02 -0.148000 1.54e-01
Signaling by NTRKs 96 1.21e-02 -0.148000 8.12e-02
Transcription of the HIV genome 65 3.90e-02 0.148000 1.80e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 473 4.74e-08 -0.148000 1.28e-06
AKT phosphorylates targets in the cytosol 14 3.38e-01 0.148000 5.95e-01
Glycosphingolipid catabolism 24 2.11e-01 -0.148000 4.77e-01
Signaling by EGFR 36 1.26e-01 -0.148000 3.53e-01
The citric acid (TCA) cycle and respiratory electron transport 169 9.83e-04 -0.148000 1.21e-02
Syndecan interactions 15 3.23e-01 -0.147000 5.84e-01
Regulation of NPAS4 gene expression 11 3.98e-01 -0.147000 6.50e-01
G1/S-Specific Transcription 15 3.25e-01 0.147000 5.84e-01
Activation of HOX genes during differentiation 45 8.91e-02 -0.147000 3.01e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 45 8.91e-02 -0.147000 3.01e-01
Interleukin-12 family signaling 42 1.01e-01 -0.146000 3.16e-01
Activation of G protein gated Potassium channels 10 4.24e-01 0.146000 6.70e-01
G protein gated Potassium channels 10 4.24e-01 0.146000 6.70e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 10 4.24e-01 0.146000 6.70e-01
Plasma lipoprotein remodeling 13 3.63e-01 -0.146000 6.17e-01
FGFR2 alternative splicing 24 2.18e-01 -0.145000 4.81e-01
PIWI-interacting RNA (piRNA) biogenesis 17 2.99e-01 -0.145000 5.64e-01
Collagen biosynthesis and modifying enzymes 16 3.15e-01 0.145000 5.78e-01
Autophagy 129 4.63e-03 -0.145000 4.03e-02
Nef mediated downregulation of MHC class I complex cell surface expression 10 4.28e-01 -0.145000 6.73e-01
Negative regulation of FGFR2 signaling 17 3.07e-01 -0.143000 5.72e-01
Negative regulation of FGFR3 signaling 17 3.07e-01 -0.143000 5.72e-01
Negative regulation of FGFR4 signaling 17 3.07e-01 -0.143000 5.72e-01
Immune System 1357 1.47e-17 -0.143000 8.27e-16
Signaling by Hippo 13 3.73e-01 0.143000 6.24e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 26 2.09e-01 0.142000 4.74e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 34 1.52e-01 -0.142000 3.91e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 30 1.78e-01 -0.142000 4.35e-01
N-glycan antennae elongation in the medial/trans-Golgi 15 3.42e-01 0.142000 5.95e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 3.42e-01 -0.142000 5.95e-01
Base-Excision Repair, AP Site Formation 16 3.26e-01 0.142000 5.84e-01
Assembly of the pre-replicative complex 75 3.46e-02 0.141000 1.75e-01
Synthesis of PIPs at the early endosome membrane 15 3.44e-01 -0.141000 5.98e-01
RUNX3 regulates p14-ARF 10 4.40e-01 -0.141000 6.84e-01
Downstream signal transduction 24 2.35e-01 -0.140000 4.98e-01
Extracellular matrix organization 99 1.64e-02 -0.140000 1.02e-01
Toll-like Receptor Cascades 139 4.59e-03 -0.140000 4.02e-02
TRAF6 mediated NF-kB activation 20 2.81e-01 -0.139000 5.46e-01
HIV Transcription Initiation 42 1.19e-01 0.139000 3.46e-01
RNA Polymerase II HIV Promoter Escape 42 1.19e-01 0.139000 3.46e-01
RNA Polymerase II Promoter Escape 42 1.19e-01 0.139000 3.46e-01
RNA Polymerase II Transcription Initiation 42 1.19e-01 0.139000 3.46e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 42 1.19e-01 0.139000 3.46e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 42 1.19e-01 0.139000 3.46e-01
Mitochondrial tRNA aminoacylation 14 3.70e-01 0.139000 6.19e-01
Regulation of PTEN mRNA translation 11 4.27e-01 -0.138000 6.73e-01
G2/M DNA damage checkpoint 49 9.52e-02 0.138000 3.10e-01
Signaling by NTRK1 (TRKA) 84 2.92e-02 -0.138000 1.55e-01
Complex I biogenesis 57 7.48e-02 -0.137000 2.70e-01
RIPK1-mediated regulated necrosis 29 2.03e-01 -0.137000 4.68e-01
Regulation of necroptotic cell death 29 2.03e-01 -0.137000 4.68e-01
G beta:gamma signalling through PI3Kgamma 17 3.30e-01 -0.136000 5.88e-01
Presynaptic phase of homologous DNA pairing and strand exchange 31 1.89e-01 0.136000 4.52e-01
Oncogenic MAPK signaling 66 5.64e-02 -0.136000 2.29e-01
Basigin interactions 17 3.34e-01 -0.135000 5.90e-01
GPCR downstream signalling 201 1.02e-03 -0.135000 1.23e-02
Autodegradation of Cdh1 by Cdh1:APC/C 62 6.64e-02 0.135000 2.53e-01
Nicotinamide salvaging 13 4.00e-01 -0.135000 6.51e-01
Death Receptor Signaling 120 1.09e-02 -0.135000 7.55e-02
NOTCH1 Intracellular Domain Regulates Transcription 41 1.35e-01 -0.135000 3.67e-01
Signaling by FGFR1 in disease 26 2.36e-01 -0.134000 4.98e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 20 2.99e-01 -0.134000 5.64e-01
Signaling by high-kinase activity BRAF mutants 27 2.28e-01 -0.134000 4.94e-01
Pre-NOTCH Transcription and Translation 30 2.06e-01 -0.133000 4.74e-01
Pre-NOTCH Expression and Processing 45 1.23e-01 -0.133000 3.50e-01
Processive synthesis on the lagging strand 14 3.91e-01 0.132000 6.43e-01
STING mediated induction of host immune responses 12 4.27e-01 -0.132000 6.73e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 44 1.29e-01 -0.132000 3.58e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 26 2.47e-01 0.131000 5.13e-01
Cross-presentation of soluble exogenous antigens (endosomes) 46 1.24e-01 0.131000 3.51e-01
Mitochondrial protein import 63 7.25e-02 0.131000 2.66e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 49 1.13e-01 -0.131000 3.39e-01
RMTs methylate histone arginines 30 2.15e-01 -0.131000 4.77e-01
Diseases of mitotic cell cycle 30 2.15e-01 0.131000 4.77e-01
Activation of BAD and translocation to mitochondria 14 3.98e-01 0.130000 6.50e-01
Azathioprine ADME 16 3.67e-01 0.130000 6.18e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 35 1.83e-01 -0.130000 4.39e-01
Signaling by RAS mutants 35 1.83e-01 -0.130000 4.39e-01
Signaling by moderate kinase activity BRAF mutants 35 1.83e-01 -0.130000 4.39e-01
Signaling downstream of RAS mutants 35 1.83e-01 -0.130000 4.39e-01
Activation of BH3-only proteins 26 2.51e-01 0.130000 5.16e-01
Condensation of Prophase Chromosomes 11 4.56e-01 -0.130000 6.93e-01
Cytokine Signaling in Immune system 530 5.09e-07 -0.129000 1.20e-05
Signaling by SCF-KIT 34 1.93e-01 -0.129000 4.58e-01
HCMV Early Events 65 7.26e-02 -0.129000 2.66e-01
Anti-inflammatory response favouring Leishmania parasite infection 46 1.31e-01 -0.129000 3.59e-01
Leishmania parasite growth and survival 46 1.31e-01 -0.129000 3.59e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 15 3.89e-01 -0.129000 6.42e-01
activated TAK1 mediates p38 MAPK activation 20 3.24e-01 -0.127000 5.84e-01
Estrogen-dependent gene expression 78 5.23e-02 -0.127000 2.18e-01
Macroautophagy 117 1.79e-02 -0.127000 1.08e-01
Somitogenesis 46 1.36e-01 0.127000 3.67e-01
mRNA Splicing - Minor Pathway 50 1.21e-01 -0.127000 3.49e-01
Cell-cell junction organization 32 2.15e-01 -0.127000 4.77e-01
Factors involved in megakaryocyte development and platelet production 92 3.70e-02 -0.126000 1.75e-01
Constitutive Signaling by Overexpressed ERBB2 10 4.90e-01 -0.126000 7.22e-01
Transmission across Chemical Synapses 103 2.77e-02 -0.126000 1.52e-01
DNA Replication 102 2.85e-02 0.126000 1.54e-01
Regulation of IFNA/IFNB signaling 11 4.71e-01 -0.126000 7.03e-01
tRNA Aminoacylation 20 3.33e-01 0.125000 5.90e-01
PLC beta mediated events 33 2.15e-01 -0.125000 4.77e-01
Synthesis of PIPs at the plasma membrane 44 1.53e-01 -0.125000 3.93e-01
Protein folding 68 7.69e-02 -0.124000 2.74e-01
STAT3 nuclear events downstream of ALK signaling 10 4.97e-01 -0.124000 7.27e-01
Stimuli-sensing channels 42 1.66e-01 -0.124000 4.14e-01
Synthesis of PIPs at the late endosome membrane 10 5.00e-01 -0.123000 7.28e-01
Nuclear Pore Complex (NPC) Disassembly 33 2.21e-01 -0.123000 4.84e-01
Cellular responses to stimuli 634 1.93e-07 -0.123000 4.82e-06
Chromatin modifying enzymes 188 3.97e-03 -0.122000 3.60e-02
Chromatin organization 188 3.97e-03 -0.122000 3.60e-02
RHOG GTPase cycle 57 1.11e-01 -0.122000 3.36e-01
Triglyceride catabolism 13 4.46e-01 -0.122000 6.85e-01
Platelet Aggregation (Plug Formation) 22 3.22e-01 -0.122000 5.84e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 66 8.68e-02 0.122000 2.96e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 66 8.68e-02 0.122000 2.96e-01
SUMOylation of DNA methylation proteins 13 4.47e-01 0.122000 6.85e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 49 1.42e-01 -0.122000 3.76e-01
Cell recruitment (pro-inflammatory response) 22 3.25e-01 -0.121000 5.84e-01
Purinergic signaling in leishmaniasis infection 22 3.25e-01 -0.121000 5.84e-01
Negative regulation of MAPK pathway 36 2.09e-01 -0.121000 4.74e-01
Cytoprotection by HMOX1 57 1.15e-01 -0.121000 3.41e-01
SARS-CoV-2 modulates autophagy 11 4.88e-01 -0.121000 7.21e-01
G-protein activation 13 4.51e-01 0.121000 6.88e-01
G1/S Transition 103 3.48e-02 0.121000 1.75e-01
Regulation of RUNX1 Expression and Activity 17 3.91e-01 -0.120000 6.43e-01
Cellular responses to stress 626 4.31e-07 -0.120000 1.03e-05
Disease 1211 8.69e-12 -0.120000 2.89e-10
BBSome-mediated cargo-targeting to cilium 17 3.92e-01 0.120000 6.43e-01
DCC mediated attractive signaling 10 5.12e-01 -0.120000 7.37e-01
Class B/2 (Secretin family receptors) 19 3.66e-01 0.120000 6.18e-01
Signaling by PDGF 34 2.28e-01 -0.120000 4.94e-01
Cell surface interactions at the vascular wall 76 7.19e-02 -0.120000 2.66e-01
Hemostasis 346 1.51e-04 -0.120000 2.48e-03
G2/M Checkpoints 105 3.50e-02 0.119000 1.75e-01
Nucleotide catabolism 25 3.03e-01 -0.119000 5.68e-01
Budding and maturation of HIV virion 34 2.30e-01 0.119000 4.95e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 64 1.01e-01 0.119000 3.16e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 64 1.01e-01 0.119000 3.16e-01
Mitochondrial translation 94 4.80e-02 0.118000 2.03e-01
Glyoxylate metabolism and glycine degradation 21 3.49e-01 0.118000 6.04e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 4.45e-01 0.118000 6.85e-01
CDK-mediated phosphorylation and removal of Cdc6 64 1.04e-01 0.118000 3.19e-01
RHOF GTPase cycle 30 2.65e-01 -0.118000 5.31e-01
ABC-family proteins mediated transport 77 7.56e-02 0.117000 2.70e-01
ERKs are inactivated 12 4.83e-01 0.117000 7.16e-01
Negative epigenetic regulation of rRNA expression 42 1.90e-01 -0.117000 4.54e-01
Extension of Telomeres 40 2.01e-01 0.117000 4.66e-01
APC/C-mediated degradation of cell cycle proteins 74 8.32e-02 0.117000 2.88e-01
Regulation of mitotic cell cycle 74 8.32e-02 0.117000 2.88e-01
Toll Like Receptor 4 (TLR4) Cascade 123 2.59e-02 -0.117000 1.44e-01
Notch-HLH transcription pathway 26 3.05e-01 -0.116000 5.70e-01
Defective CFTR causes cystic fibrosis 57 1.30e-01 0.116000 3.59e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 22 3.47e-01 -0.116000 6.01e-01
Signal transduction by L1 15 4.40e-01 -0.115000 6.84e-01
Intrinsic Pathway for Apoptosis 49 1.64e-01 0.115000 4.13e-01
Protein methylation 14 4.57e-01 -0.115000 6.93e-01
Signaling by FGFR in disease 42 2.00e-01 -0.114000 4.66e-01
Translesion synthesis by POLI 16 4.29e-01 -0.114000 6.74e-01
Mitochondrial translation termination 88 6.47e-02 0.114000 2.48e-01
tRNA processing in the nucleus 56 1.40e-01 0.114000 3.74e-01
Post-translational protein phosphorylation 43 1.96e-01 -0.114000 4.61e-01
Interleukin-37 signaling 15 4.45e-01 -0.114000 6.85e-01
Sensory Perception 74 9.09e-02 -0.114000 3.04e-01
PKA-mediated phosphorylation of CREB 13 4.79e-01 -0.114000 7.12e-01
RHO GTPase Effectors 193 6.85e-03 -0.113000 5.48e-02
Asymmetric localization of PCP proteins 51 1.62e-01 0.113000 4.10e-01
G alpha (i) signalling events 96 5.60e-02 -0.113000 2.28e-01
Signaling by FGFR2 49 1.72e-01 -0.113000 4.24e-01
G alpha (s) signalling events 46 1.86e-01 -0.113000 4.46e-01
Regulation of MECP2 expression and activity 27 3.12e-01 -0.112000 5.78e-01
NOTCH4 Intracellular Domain Regulates Transcription 14 4.67e-01 -0.112000 7.01e-01
Signaling by FGFR 55 1.52e-01 -0.112000 3.91e-01
Synthesis of DNA 97 5.90e-02 0.111000 2.36e-01
Beta-oxidation of very long chain fatty acids 10 5.44e-01 0.111000 7.57e-01
Glutathione conjugation 19 4.06e-01 0.110000 6.58e-01
Senescence-Associated Secretory Phenotype (SASP) 44 2.07e-01 -0.110000 4.74e-01
PI3K Cascade 18 4.20e-01 -0.110000 6.68e-01
RHOV GTPase cycle 28 3.15e-01 -0.110000 5.78e-01
Signaling by NODAL 12 5.11e-01 -0.110000 7.37e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 32 2.86e-01 0.109000 5.51e-01
Diseases of DNA Double-Strand Break Repair 32 2.86e-01 0.109000 5.51e-01
Cargo trafficking to the periciliary membrane 38 2.47e-01 0.109000 5.14e-01
Switching of origins to a post-replicative state 77 1.01e-01 0.108000 3.16e-01
Regulation of RAS by GAPs 62 1.41e-01 0.108000 3.76e-01
Transport of Mature mRNA Derived from an Intronless Transcript 41 2.32e-01 -0.108000 4.95e-01
FOXO-mediated transcription 45 2.12e-01 -0.108000 4.77e-01
Early SARS-CoV-2 Infection Events 28 3.26e-01 -0.107000 5.84e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 5.38e-01 -0.107000 7.53e-01
alpha-linolenic acid (ALA) metabolism 11 5.38e-01 -0.107000 7.53e-01
Defective pyroptosis 13 5.04e-01 0.107000 7.30e-01
RHO GTPases Activate Formins 98 6.88e-02 -0.107000 2.56e-01
G0 and Early G1 15 4.75e-01 -0.107000 7.07e-01
Ubiquitin-dependent degradation of Cyclin D 50 1.93e-01 0.106000 4.58e-01
Metabolism of porphyrins 19 4.23e-01 0.106000 6.70e-01
Interleukin-12 signaling 37 2.65e-01 -0.106000 5.31e-01
Regulation of PTEN gene transcription 53 1.83e-01 0.106000 4.39e-01
Antiviral mechanism by IFN-stimulated genes 128 3.96e-02 -0.106000 1.80e-01
Chaperonin-mediated protein folding 63 1.48e-01 -0.106000 3.86e-01
Metabolism of vitamins and cofactors 122 4.50e-02 0.105000 1.98e-01
Lagging Strand Synthesis 18 4.41e-01 0.105000 6.84e-01
Constitutive Signaling by EGFRvIII 12 5.29e-01 -0.105000 7.47e-01
Signaling by EGFRvIII in Cancer 12 5.29e-01 -0.105000 7.47e-01
GPER1 signaling 26 3.55e-01 -0.105000 6.06e-01
Signaling by MET 50 2.01e-01 -0.105000 4.66e-01
Constitutive Signaling by AKT1 E17K in Cancer 23 3.87e-01 0.104000 6.40e-01
Glycogen metabolism 20 4.20e-01 -0.104000 6.68e-01
PRC2 methylates histones and DNA 13 5.17e-01 -0.104000 7.41e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 42 2.46e-01 -0.104000 5.12e-01
Rap1 signalling 12 5.35e-01 -0.103000 7.53e-01
TNFR1-induced proapoptotic signaling 23 3.91e-01 0.103000 6.43e-01
Export of Viral Ribonucleoproteins from Nucleus 32 3.13e-01 -0.103000 5.78e-01
RHOB GTPase cycle 44 2.37e-01 -0.103000 5.01e-01
PKMTs methylate histone lysines 36 2.86e-01 -0.103000 5.51e-01
Mitochondrial translation initiation 88 9.65e-02 0.103000 3.13e-01
Regulation of TLR by endogenous ligand 13 5.23e-01 -0.102000 7.47e-01
ISG15 antiviral mechanism 71 1.36e-01 -0.102000 3.67e-01
Signaling by RAF1 mutants 31 3.24e-01 -0.102000 5.84e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 58 1.78e-01 -0.102000 4.35e-01
Elastic fibre formation 15 4.94e-01 -0.102000 7.25e-01
Signaling by Nuclear Receptors 173 2.10e-02 -0.102000 1.24e-01
Synthesis of PC 19 4.41e-01 0.102000 6.84e-01
Meiosis 35 2.99e-01 0.101000 5.64e-01
VEGFA-VEGFR2 Pathway 79 1.24e-01 -0.100000 3.52e-01
Impaired BRCA2 binding to RAD51 27 3.69e-01 0.100000 6.19e-01
Class I peroxisomal membrane protein import 18 4.64e-01 0.099700 6.99e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 43 2.60e-01 0.099400 5.25e-01
HIV Transcription Elongation 43 2.60e-01 0.099400 5.25e-01
Tat-mediated elongation of the HIV-1 transcript 43 2.60e-01 0.099400 5.25e-01
Citric acid cycle (TCA cycle) 22 4.21e-01 -0.099200 6.69e-01
TCR signaling 98 9.07e-02 -0.099100 3.04e-01
Rab regulation of trafficking 113 6.99e-02 0.099000 2.60e-01
Termination of translesion DNA synthesis 28 3.66e-01 -0.098800 6.18e-01
Signaling by VEGF 84 1.22e-01 -0.097800 3.50e-01
rRNA modification in the nucleus and cytosol 55 2.12e-01 -0.097500 4.77e-01
Zinc transporters 11 5.76e-01 0.097500 7.68e-01
GAB1 signalosome 10 5.94e-01 0.097300 7.81e-01
Regulation of PLK1 Activity at G2/M Transition 74 1.51e-01 -0.096800 3.91e-01
Signal Transduction 1427 4.41e-09 -0.096300 1.27e-07
Metalloprotease DUBs 16 5.05e-01 -0.096300 7.31e-01
Regulation of APC/C activators between G1/S and early anaphase 69 1.68e-01 0.096000 4.17e-01
Intraflagellar transport 37 3.13e-01 0.095900 5.78e-01
Platelet homeostasis 44 2.72e-01 0.095800 5.39e-01
Phase II - Conjugation of compounds 45 2.67e-01 0.095800 5.31e-01
Nuclear Envelope (NE) Reassembly 61 1.98e-01 -0.095400 4.63e-01
MAP2K and MAPK activation 30 3.66e-01 -0.095300 6.18e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 5.85e-01 -0.095200 7.75e-01
RUNX3 regulates NOTCH signaling 13 5.52e-01 -0.095200 7.60e-01
Regulation of TNFR1 signaling 44 2.76e-01 -0.095100 5.41e-01
ER-Phagosome pathway 83 1.37e-01 -0.094600 3.67e-01
Translesion Synthesis by POLH 17 5.00e-01 -0.094500 7.28e-01
Transcriptional regulation of white adipocyte differentiation 67 1.82e-01 -0.094500 4.39e-01
Signaling by GPCR 217 1.70e-02 -0.094500 1.05e-01
Mitochondrial biogenesis 81 1.43e-01 -0.094400 3.76e-01
DNA Damage Bypass 42 2.92e-01 -0.094100 5.55e-01
SUMO E3 ligases SUMOylate target proteins 145 5.12e-02 -0.094100 2.15e-01
TRAF6 mediated IRF7 activation 15 5.28e-01 -0.094100 7.47e-01
Integrin signaling 21 4.57e-01 -0.093900 6.93e-01
Endogenous sterols 13 5.60e-01 -0.093400 7.63e-01
HCMV Infection 88 1.31e-01 -0.093400 3.59e-01
Neurotransmitter receptors and postsynaptic signal transmission 84 1.40e-01 -0.093300 3.74e-01
Homologous DNA Pairing and Strand Exchange 33 3.54e-01 0.093200 6.06e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 5.64e-01 0.092400 7.65e-01
Cellular response to heat stress 85 1.42e-01 -0.092400 3.76e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 10 6.13e-01 0.092300 7.96e-01
SCF(Skp2)-mediated degradation of p27/p21 55 2.38e-01 0.092200 5.01e-01
mRNA Capping 29 3.91e-01 0.092100 6.43e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 32 3.68e-01 -0.092000 6.19e-01
Viral Messenger RNA Synthesis 43 2.99e-01 -0.091700 5.64e-01
Processive synthesis on the C-strand of the telomere 18 5.01e-01 0.091600 7.28e-01
Ion transport by P-type ATPases 30 3.86e-01 0.091500 6.40e-01
IGF1R signaling cascade 24 4.40e-01 -0.091200 6.84e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 24 4.40e-01 -0.091200 6.84e-01
RHOC GTPase cycle 52 2.58e-01 -0.090800 5.25e-01
MicroRNA (miRNA) biogenesis 23 4.52e-01 -0.090700 6.88e-01
Signaling by Interleukins 306 6.79e-03 -0.090600 5.47e-02
Vpr-mediated nuclear import of PICs 38 3.34e-01 0.090600 5.90e-01
SUMOylation of transcription cofactors 40 3.22e-01 -0.090600 5.84e-01
NS1 Mediated Effects on Host Pathways 39 3.28e-01 -0.090500 5.86e-01
Epigenetic regulation of gene expression 116 9.38e-02 -0.090300 3.08e-01
Adaptive Immune System 560 3.14e-04 -0.090300 4.38e-03
ATF4 activates genes in response to endoplasmic reticulum stress 24 4.47e-01 0.089800 6.85e-01
Ca2+ pathway 36 3.52e-01 -0.089800 6.06e-01
ADP signalling through P2Y purinoceptor 1 16 5.35e-01 0.089600 7.53e-01
SUMOylation of SUMOylation proteins 34 3.67e-01 -0.089500 6.18e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 5.77e-01 0.089400 7.68e-01
Mitochondrial translation elongation 88 1.48e-01 0.089400 3.86e-01
Erythropoietin activates RAS 13 5.77e-01 -0.089400 7.68e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 2.67e-01 0.089100 5.31e-01
Diseases of signal transduction by growth factor receptors and second messengers 321 6.54e-03 -0.089000 5.39e-02
ERK/MAPK targets 19 5.03e-01 0.088900 7.29e-01
Regulation of Apoptosis 51 2.73e-01 0.088900 5.39e-01
RUNX2 regulates bone development 16 5.39e-01 -0.088800 7.53e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 4.25e-01 0.088800 6.71e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 4.25e-01 0.088800 6.71e-01
NoRC negatively regulates rRNA expression 40 3.34e-01 -0.088400 5.90e-01
Degradation of DVL 53 2.67e-01 0.088300 5.31e-01
Cell Cycle Checkpoints 193 3.55e-02 0.088200 1.75e-01
tRNA modification in the nucleus and cytosol 36 3.61e-01 0.088100 6.14e-01
S Phase 132 8.18e-02 0.088000 2.86e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 60 2.40e-01 0.087900 5.04e-01
Loss of Nlp from mitotic centrosomes 59 2.48e-01 -0.087000 5.14e-01
Loss of proteins required for interphase microtubule organization from the centrosome 59 2.48e-01 -0.087000 5.14e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 11 6.18e-01 -0.086900 7.98e-01
PKR-mediated signaling 57 2.61e-01 -0.086200 5.25e-01
Other interleukin signaling 16 5.51e-01 -0.086200 7.59e-01
Vif-mediated degradation of APOBEC3G 53 2.79e-01 0.086200 5.44e-01
Translation of Structural Proteins 9694635 54 2.74e-01 -0.086100 5.39e-01
TBC/RABGAPs 44 3.24e-01 0.086000 5.84e-01
ESR-mediated signaling 125 9.90e-02 -0.085700 3.13e-01
COPII-mediated vesicle transport 58 2.60e-01 0.085500 5.25e-01
ABC transporter disorders 62 2.45e-01 0.085500 5.12e-01
Signaling by FGFR1 31 4.12e-01 -0.085200 6.63e-01
Miscellaneous transport and binding events 16 5.56e-01 0.085100 7.61e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 13 5.96e-01 -0.085000 7.81e-01
Iron uptake and transport 45 3.25e-01 -0.084900 5.84e-01
PERK regulates gene expression 29 4.32e-01 0.084300 6.77e-01
Interactions of Rev with host cellular proteins 36 3.84e-01 -0.084000 6.38e-01
Sulfur amino acid metabolism 19 5.27e-01 0.083800 7.47e-01
Protein hydroxylation 15 5.74e-01 -0.083800 7.68e-01
Clathrin-mediated endocytosis 106 1.37e-01 -0.083800 3.67e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 90 1.73e-01 -0.083300 4.25e-01
DARPP-32 events 21 5.10e-01 -0.083200 7.35e-01
Toll Like Receptor 3 (TLR3) Cascade 91 1.72e-01 -0.083000 4.24e-01
Cytochrome P450 - arranged by substrate type 18 5.43e-01 -0.082900 7.57e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 6.20e-01 -0.082700 7.98e-01
Prolonged ERK activation events 12 6.20e-01 -0.082700 7.98e-01
Neuronal System 136 9.83e-02 -0.082400 3.13e-01
RNA Polymerase III Transcription Termination 20 5.24e-01 0.082300 7.47e-01
Kinesins 29 4.43e-01 -0.082300 6.85e-01
DAG and IP3 signaling 27 4.61e-01 -0.082000 6.96e-01
Transcriptional regulation by small RNAs 47 3.32e-01 -0.082000 5.90e-01
Degradation of beta-catenin by the destruction complex 75 2.21e-01 0.081900 4.84e-01
PI Metabolism 66 2.52e-01 -0.081700 5.17e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 3.28e-01 0.081700 5.86e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 29 4.47e-01 -0.081600 6.85e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 29 4.47e-01 -0.081600 6.85e-01
Peptide hormone metabolism 35 4.06e-01 -0.081200 6.58e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 10 6.57e-01 0.081000 8.25e-01
FGFR2 mutant receptor activation 16 5.75e-01 -0.081000 7.68e-01
Signaling by FGFR2 IIIa TM 16 5.75e-01 -0.081000 7.68e-01
Signaling by FGFR3 25 4.84e-01 -0.080900 7.16e-01
Signaling by FGFR4 25 4.84e-01 -0.080900 7.16e-01
Dectin-1 mediated noncanonical NF-kB signaling 59 2.84e-01 0.080800 5.50e-01
NEP/NS2 Interacts with the Cellular Export Machinery 31 4.37e-01 -0.080700 6.83e-01
Integration of energy metabolism 56 2.97e-01 0.080600 5.64e-01
RAB GEFs exchange GTP for GDP on RABs 81 2.13e-01 0.080200 4.77e-01
Heme signaling 37 3.99e-01 -0.080200 6.51e-01
Diseases associated with glycosaminoglycan metabolism 18 5.56e-01 0.080100 7.61e-01
TP53 Regulates Metabolic Genes 81 2.14e-01 -0.080100 4.77e-01
Assembly Of The HIV Virion 22 5.16e-01 0.080000 7.41e-01
Global Genome Nucleotide Excision Repair (GG-NER) 78 2.28e-01 0.079100 4.94e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 25 4.94e-01 -0.079100 7.25e-01
Mitotic G1 phase and G1/S transition 116 1.44e-01 0.078800 3.79e-01
HDR through Single Strand Annealing (SSA) 29 4.64e-01 0.078700 6.99e-01
Opioid Signalling 59 2.99e-01 -0.078200 5.64e-01
FOXO-mediated transcription of cell cycle genes 11 6.55e-01 0.077800 8.23e-01
TNF signaling 52 3.33e-01 -0.077700 5.90e-01
RNA Polymerase II Pre-transcription Events 74 2.51e-01 0.077400 5.16e-01
Late Phase of HIV Life Cycle 135 1.23e-01 0.077100 3.50e-01
Methylation 10 6.73e-01 0.077100 8.34e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 20 5.51e-01 -0.077000 7.59e-01
NIK–>noncanonical NF-kB signaling 57 3.15e-01 0.077000 5.78e-01
IRS-related events triggered by IGF1R 23 5.26e-01 -0.076500 7.47e-01
PI3K/AKT Signaling in Cancer 49 3.55e-01 -0.076400 6.06e-01
Translesion synthesis by POLK 16 5.97e-01 -0.076400 7.81e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 98 1.96e-01 -0.075800 4.61e-01
Toll Like Receptor 2 (TLR2) Cascade 98 1.96e-01 -0.075800 4.61e-01
Toll Like Receptor TLR1:TLR2 Cascade 98 1.96e-01 -0.075800 4.61e-01
Toll Like Receptor TLR6:TLR2 Cascade 98 1.96e-01 -0.075800 4.61e-01
G beta:gamma signalling through PLC beta 11 6.64e-01 -0.075800 8.28e-01
Presynaptic function of Kainate receptors 11 6.64e-01 -0.075800 8.28e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 3.86e-01 0.075600 6.40e-01
Heparan sulfate/heparin (HS-GAG) metabolism 27 4.97e-01 0.075500 7.27e-01
SCF-beta-TrCP mediated degradation of Emi1 51 3.52e-01 0.075400 6.06e-01
Cellular response to hypoxia 67 2.89e-01 0.075100 5.52e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 161 1.02e-01 0.075000 3.17e-01
Deposition of new CENPA-containing nucleosomes at the centromere 20 5.62e-01 -0.075000 7.64e-01
Nucleosome assembly 20 5.62e-01 -0.075000 7.64e-01
Hedgehog ligand biogenesis 56 3.33e-01 0.074900 5.90e-01
Metabolism of nucleotides 77 2.57e-01 0.074900 5.25e-01
Hh mutants abrogate ligand secretion 54 3.42e-01 0.074900 5.95e-01
Caspase activation via extrinsic apoptotic signalling pathway 20 5.64e-01 0.074600 7.65e-01
Ribavirin ADME 10 6.83e-01 -0.074500 8.37e-01
Formation of the beta-catenin:TCF transactivating complex 24 5.28e-01 -0.074400 7.47e-01
Protein ubiquitination 59 3.24e-01 -0.074300 5.84e-01
Processing of Intronless Pre-mRNAs 20 5.66e-01 -0.074200 7.66e-01
Binding and Uptake of Ligands by Scavenger Receptors 20 5.66e-01 -0.074100 7.66e-01
AURKA Activation by TPX2 60 3.23e-01 -0.073800 5.84e-01
MyD88 dependent cascade initiated on endosome 89 2.30e-01 -0.073700 4.95e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 11 6.72e-01 0.073700 8.34e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 11 6.72e-01 0.073700 8.34e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 3.74e-01 0.073600 6.24e-01
Translesion synthesis by REV1 15 6.23e-01 -0.073400 7.99e-01
PKA activation 11 6.74e-01 -0.073200 8.34e-01
Nuclear import of Rev protein 33 4.68e-01 -0.073100 7.01e-01
Toll Like Receptor 9 (TLR9) Cascade 93 2.26e-01 -0.072800 4.93e-01
Vpu mediated degradation of CD4 51 3.70e-01 0.072700 6.19e-01
Hh mutants are degraded by ERAD 53 3.62e-01 0.072400 6.16e-01
Regulation of RUNX3 expression and activity 55 3.54e-01 0.072300 6.06e-01
Mitotic Spindle Checkpoint 80 2.65e-01 0.072200 5.31e-01
Signaling by ERBB2 ECD mutants 12 6.66e-01 -0.072100 8.29e-01
Transport of bile salts and organic acids, metal ions and amine compounds 35 4.61e-01 -0.072000 6.96e-01
Gene Silencing by RNA 66 3.13e-01 -0.071900 5.78e-01
Collagen formation 27 5.18e-01 -0.071900 7.41e-01
Transport of the SLBP independent Mature mRNA 34 4.69e-01 -0.071800 7.01e-01
SLC transporter disorders 56 3.54e-01 -0.071700 6.06e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 75 2.86e-01 0.071400 5.51e-01
mTORC1-mediated signalling 24 5.46e-01 0.071300 7.57e-01
MyD88-independent TLR4 cascade 96 2.35e-01 -0.070200 4.98e-01
TRIF(TICAM1)-mediated TLR4 signaling 96 2.35e-01 -0.070200 4.98e-01
Glycerophospholipid biosynthesis 78 2.88e-01 0.069700 5.52e-01
PKA activation in glucagon signalling 10 7.03e-01 -0.069700 8.53e-01
Interleukin-6 family signaling 10 7.05e-01 -0.069100 8.53e-01
Antigen processing: Ubiquitination & Proteasome degradation 251 6.18e-02 0.068900 2.43e-01
Nucleotide salvage 20 5.95e-01 0.068700 7.81e-01
MECP2 regulates neuronal receptors and channels 10 7.07e-01 -0.068700 8.53e-01
Potassium Channels 20 5.95e-01 0.068600 7.81e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 61 3.55e-01 0.068600 6.06e-01
UCH proteinases 81 2.87e-01 0.068500 5.52e-01
MyD88 cascade initiated on plasma membrane 84 2.79e-01 -0.068500 5.44e-01
Toll Like Receptor 10 (TLR10) Cascade 84 2.79e-01 -0.068500 5.44e-01
Toll Like Receptor 5 (TLR5) Cascade 84 2.79e-01 -0.068500 5.44e-01
Late SARS-CoV-2 Infection Events 58 3.69e-01 -0.068300 6.19e-01
ZBP1(DAI) mediated induction of type I IFNs 18 6.18e-01 -0.067900 7.98e-01
SUMOylation 151 1.51e-01 -0.067900 3.91e-01
DNA Double Strand Break Response 40 4.58e-01 -0.067800 6.94e-01
Initiation of Nuclear Envelope (NE) Reformation 16 6.39e-01 -0.067800 8.11e-01
PCNA-Dependent Long Patch Base Excision Repair 18 6.20e-01 0.067600 7.98e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 49 4.14e-01 0.067500 6.63e-01
p53-Independent DNA Damage Response 49 4.14e-01 0.067500 6.63e-01
p53-Independent G1/S DNA damage checkpoint 49 4.14e-01 0.067500 6.63e-01
Transport of the SLBP Dependant Mature mRNA 35 4.90e-01 -0.067500 7.22e-01
Diseases associated with O-glycosylation of proteins 15 6.51e-01 0.067500 8.22e-01
Recruitment of NuMA to mitotic centrosomes 74 3.17e-01 -0.067400 5.79e-01
Telomere Extension By Telomerase 17 6.34e-01 0.066700 8.08e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 88 2.81e-01 -0.066600 5.46e-01
Phase I - Functionalization of compounds 36 4.92e-01 -0.066300 7.23e-01
EML4 and NUDC in mitotic spindle formation 78 3.14e-01 -0.066000 5.78e-01
Non-integrin membrane-ECM interactions 21 6.01e-01 0.066000 7.84e-01
Synthesis of glycosylphosphatidylinositol (GPI) 16 6.48e-01 0.065900 8.19e-01
Insulin receptor signalling cascade 27 5.54e-01 -0.065900 7.61e-01
Inhibition of DNA recombination at telomere 21 6.02e-01 -0.065900 7.84e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 6.62e-01 0.065300 8.27e-01
GPCR ligand binding 69 3.50e-01 0.065100 6.05e-01
Cellular response to chemical stress 187 1.28e-01 -0.064800 3.56e-01
Diseases of DNA repair 40 4.82e-01 0.064400 7.15e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 29 5.51e-01 -0.064100 7.59e-01
Formation of paraxial mesoderm 55 4.18e-01 0.063300 6.66e-01
CRMPs in Sema3A signaling 11 7.18e-01 -0.063000 8.57e-01
Neddylation 194 1.34e-01 0.062700 3.64e-01
Transport of Ribonucleoproteins into the Host Nucleus 31 5.46e-01 -0.062700 7.57e-01
Synthesis of very long-chain fatty acyl-CoAs 15 6.76e-01 -0.062300 8.34e-01
G alpha (z) signalling events 23 6.06e-01 0.062100 7.89e-01
Base Excision Repair 40 4.99e-01 0.061800 7.28e-01
p130Cas linkage to MAPK signaling for integrins 10 7.35e-01 0.061700 8.65e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 39 5.06e-01 -0.061600 7.31e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 13 7.01e-01 0.061500 8.52e-01
Signaling by FLT3 ITD and TKD mutants 14 6.91e-01 0.061500 8.43e-01
Orc1 removal from chromatin 60 4.13e-01 0.061100 6.63e-01
Formation of the Early Elongation Complex 33 5.45e-01 0.060900 7.57e-01
Formation of the HIV-1 Early Elongation Complex 33 5.45e-01 0.060900 7.57e-01
Golgi Associated Vesicle Biogenesis 51 4.53e-01 0.060800 6.90e-01
Diseases of metabolism 130 2.33e-01 0.060700 4.98e-01
Metabolism of steroids 101 2.93e-01 0.060600 5.57e-01
Degradation of cysteine and homocysteine 10 7.40e-01 0.060600 8.66e-01
Cyclin D associated events in G1 37 5.25e-01 -0.060400 7.47e-01
G1 Phase 37 5.25e-01 -0.060400 7.47e-01
RNA Polymerase I Transcription Termination 24 6.11e-01 -0.060100 7.94e-01
Protein-protein interactions at synapses 32 5.58e-01 0.059900 7.63e-01
Molecules associated with elastic fibres 12 7.22e-01 -0.059300 8.58e-01
Cyclin E associated events during G1/S transition 74 3.80e-01 0.059100 6.33e-01
Rev-mediated nuclear export of HIV RNA 34 5.51e-01 -0.059100 7.59e-01
Signalling to ERKs 27 5.97e-01 0.058800 7.81e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 6.26e-01 -0.058700 8.01e-01
Myogenesis 14 7.04e-01 -0.058600 8.53e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 49 4.79e-01 -0.058500 7.12e-01
NOD1/2 Signaling Pathway 31 5.76e-01 -0.058000 7.68e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 17 6.80e-01 0.057800 8.37e-01
Disorders of Developmental Biology 11 7.41e-01 -0.057600 8.66e-01
Disorders of Nervous System Development 11 7.41e-01 -0.057600 8.66e-01
Loss of function of MECP2 in Rett syndrome 11 7.41e-01 -0.057600 8.66e-01
Pervasive developmental disorders 11 7.41e-01 -0.057600 8.66e-01
Glycosaminoglycan metabolism 67 4.16e-01 0.057600 6.64e-01
RORA activates gene expression 17 6.82e-01 -0.057500 8.37e-01
Cilium Assembly 149 2.28e-01 0.057400 4.94e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 61 4.42e-01 -0.057100 6.84e-01
Negative regulation of NOTCH4 signaling 53 4.74e-01 0.057000 7.06e-01
Golgi Cisternae Pericentriolar Stack Reorganization 11 7.44e-01 0.056900 8.67e-01
Mismatch Repair 14 7.14e-01 0.056700 8.56e-01
Cargo recognition for clathrin-mediated endocytosis 71 4.12e-01 -0.056300 6.63e-01
HIV Life Cycle 148 2.41e-01 0.056000 5.07e-01
RHOJ GTPase cycle 45 5.17e-01 -0.055900 7.41e-01
Signal regulatory protein family interactions 11 7.49e-01 -0.055800 8.71e-01
PPARA activates gene expression 95 3.53e-01 -0.055200 6.06e-01
Activation of NF-kappaB in B cells 64 4.46e-01 0.055200 6.85e-01
Meiotic synapsis 20 6.75e-01 0.054100 8.34e-01
Costimulation by the CD28 family 51 5.05e-01 -0.054100 7.30e-01
Signaling by NOTCH 148 2.58e-01 -0.054000 5.25e-01
RHO GTPases activate PAKs 16 7.08e-01 0.054000 8.54e-01
Regulated Necrosis 52 5.01e-01 -0.054000 7.28e-01
Dual incision in TC-NER 62 4.66e-01 -0.053600 7.01e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 53 5.01e-01 0.053600 7.28e-01
Aquaporin-mediated transport 22 6.64e-01 0.053500 8.28e-01
RNA Polymerase I Promoter Escape 26 6.38e-01 -0.053300 8.11e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 21 6.73e-01 0.053200 8.34e-01
Insulin processing 16 7.13e-01 0.053200 8.56e-01
ADP signalling through P2Y purinoceptor 12 11 7.60e-01 -0.053100 8.76e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 17 7.05e-01 -0.053000 8.53e-01
PCP/CE pathway 70 4.47e-01 0.052700 6.85e-01
Pyruvate metabolism 26 6.43e-01 0.052500 8.15e-01
SUMOylation of RNA binding proteins 44 5.47e-01 -0.052500 7.57e-01
Regulation of lipid metabolism by PPARalpha 97 3.77e-01 -0.052100 6.28e-01
Chondroitin sulfate/dermatan sulfate metabolism 28 6.36e-01 -0.051800 8.09e-01
RNA Polymerase III Chain Elongation 17 7.12e-01 0.051700 8.56e-01
Resolution of Sister Chromatid Cohesion 84 4.16e-01 -0.051500 6.64e-01
Nuclear events mediated by NFE2L2 89 4.03e-01 -0.051400 6.56e-01
MET promotes cell motility 18 7.06e-01 0.051300 8.53e-01
RNA Polymerase I Transcription Initiation 40 5.77e-01 -0.051000 7.68e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 33 6.14e-01 0.050800 7.96e-01
SUMOylation of intracellular receptors 23 6.74e-01 -0.050700 8.34e-01
Homology Directed Repair 80 4.35e-01 0.050600 6.80e-01
Degradation of AXIN 52 5.28e-01 0.050600 7.47e-01
Pyroptosis 23 6.76e-01 0.050300 8.34e-01
MAPK targets/ Nuclear events mediated by MAP kinases 27 6.53e-01 0.050100 8.22e-01
Cyclin A:Cdk2-associated events at S phase entry 76 4.59e-01 0.049200 6.95e-01
Maturation of spike protein 9694548 34 6.23e-01 -0.048800 7.99e-01
Fc epsilon receptor (FCERI) signaling 117 3.64e-01 -0.048700 6.17e-01
Inwardly rectifying K+ channels 11 7.80e-01 0.048700 8.89e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 52 5.47e-01 0.048400 7.57e-01
Membrane Trafficking 497 6.84e-02 0.048300 2.56e-01
Cargo concentration in the ER 24 6.82e-01 -0.048300 8.37e-01
Metabolism of proteins 1339 4.25e-03 -0.048200 3.75e-02
Cholesterol biosynthesis 25 6.77e-01 0.048100 8.34e-01
Regulation of TP53 Activity through Acetylation 28 6.61e-01 -0.047900 8.27e-01
Downstream signaling events of B Cell Receptor (BCR) 77 4.69e-01 0.047800 7.01e-01
Tie2 Signaling 13 7.66e-01 0.047700 8.79e-01
Apoptotic factor-mediated response 19 7.20e-01 0.047600 8.57e-01
Transport of vitamins, nucleosides, and related molecules 25 6.82e-01 0.047400 8.37e-01
RAS processing 20 7.18e-01 0.046600 8.57e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 62 5.26e-01 -0.046600 7.47e-01
Formation of TC-NER Pre-Incision Complex 53 5.60e-01 -0.046400 7.63e-01
Stabilization of p53 54 5.56e-01 0.046400 7.61e-01
Synthesis of bile acids and bile salts 17 7.42e-01 -0.046200 8.66e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 14 7.65e-01 0.046200 8.79e-01
Signaling by Retinoic Acid 25 6.94e-01 -0.045500 8.46e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 7.95e-01 -0.045300 8.95e-01
Transcriptional Regulation by VENTX 34 6.48e-01 -0.045300 8.19e-01
Hedgehog ‘on’ state 65 5.29e-01 0.045200 7.47e-01
Signaling by PDGFR in disease 19 7.34e-01 -0.045100 8.65e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 10 8.05e-01 0.045100 9.04e-01
Mitochondrial calcium ion transport 20 7.27e-01 0.045100 8.61e-01
Interactions of Vpr with host cellular proteins 41 6.20e-01 0.044900 7.98e-01
Sialic acid metabolism 23 7.10e-01 0.044800 8.55e-01
Formation of WDR5-containing histone-modifying complexes 40 6.26e-01 -0.044500 8.01e-01
VEGFR2 mediated vascular permeability 21 7.26e-01 -0.044200 8.60e-01
CD28 dependent PI3K/Akt signaling 19 7.39e-01 0.044200 8.66e-01
Class A/1 (Rhodopsin-like receptors) 50 5.90e-01 0.044100 7.81e-01
Extra-nuclear estrogen signaling 50 5.91e-01 -0.044000 7.81e-01
Degradation of GLI2 by the proteasome 56 5.70e-01 0.043900 7.67e-01
GLI3 is processed to GLI3R by the proteasome 56 5.70e-01 0.043900 7.67e-01
Telomere Maintenance 55 5.76e-01 0.043600 7.68e-01
Interleukin-7 signaling 12 7.95e-01 -0.043400 8.95e-01
Glycogen breakdown (glycogenolysis) 12 7.95e-01 0.043400 8.95e-01
Peroxisomal protein import 52 5.91e-01 -0.043200 7.81e-01
Metabolism of non-coding RNA 50 5.98e-01 -0.043100 7.81e-01
snRNP Assembly 50 5.98e-01 -0.043100 7.81e-01
Adrenaline,noradrenaline inhibits insulin secretion 10 8.14e-01 -0.043100 9.07e-01
RHOD GTPase cycle 39 6.42e-01 -0.043000 8.14e-01
HCMV Late Events 53 5.90e-01 -0.042800 7.81e-01
Centrosome maturation 70 5.37e-01 -0.042800 7.53e-01
Recruitment of mitotic centrosome proteins and complexes 70 5.37e-01 -0.042800 7.53e-01
Interleukin-17 signaling 59 5.71e-01 -0.042700 7.68e-01
Nuclear Envelope Breakdown 47 6.15e-01 -0.042400 7.97e-01
RNA Polymerase I Promoter Clearance 44 6.30e-01 -0.042100 8.04e-01
RNA Polymerase I Transcription 44 6.30e-01 -0.042100 8.04e-01
Insulin receptor recycling 22 7.33e-01 -0.042000 8.65e-01
Sphingolipid metabolism 63 5.69e-01 0.041500 7.67e-01
RUNX2 regulates osteoblast differentiation 12 8.06e-01 -0.041000 9.04e-01
Signaling by ERBB2 TMD/JMD mutants 10 8.23e-01 0.040900 9.12e-01
Signaling by Insulin receptor 48 6.25e-01 -0.040800 8.01e-01
ATF6 (ATF6-alpha) activates chaperones 12 8.07e-01 -0.040800 9.04e-01
Signaling by ERBB2 in Cancer 14 7.92e-01 -0.040800 8.95e-01
ADORA2B mediated anti-inflammatory cytokines production 24 7.30e-01 -0.040700 8.63e-01
Regulation of PTEN stability and activity 65 5.74e-01 0.040400 7.68e-01
G alpha (q) signalling events 72 5.55e-01 -0.040300 7.61e-01
Vesicle-mediated transport 515 1.24e-01 0.040100 3.52e-01
TNFs bind their physiological receptors 10 8.27e-01 -0.040000 9.15e-01
Bile acid and bile salt metabolism 19 7.63e-01 -0.039900 8.78e-01
Regulation of HSF1-mediated heat shock response 70 5.65e-01 -0.039900 7.65e-01
GABA receptor activation 17 7.77e-01 0.039700 8.87e-01
Unfolded Protein Response (UPR) 80 5.43e-01 0.039400 7.57e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 17 7.79e-01 -0.039400 8.88e-01
Separation of Sister Chromatids 146 4.14e-01 0.039300 6.63e-01
Maturation of nucleoprotein 9683610 11 8.22e-01 -0.039200 9.12e-01
MAP kinase activation 57 6.10e-01 -0.039100 7.94e-01
SUMOylation of ubiquitinylation proteins 38 6.77e-01 -0.039100 8.34e-01
HS-GAG biosynthesis 15 7.95e-01 0.038800 8.95e-01
Ub-specific processing proteases 140 4.32e-01 -0.038600 6.77e-01
RND3 GTPase cycle 27 7.29e-01 0.038600 8.63e-01
Nuclear Receptor transcription pathway 29 7.20e-01 -0.038500 8.57e-01
IRS-mediated signalling 22 7.55e-01 -0.038400 8.73e-01
Activation of kainate receptors upon glutamate binding 13 8.13e-01 0.037900 9.07e-01
Deadenylation-dependent mRNA decay 49 6.54e-01 -0.037100 8.23e-01
Metabolism of nitric oxide: NOS3 activation and regulation 10 8.39e-01 0.037000 9.18e-01
Signaling by FLT3 fusion proteins 18 7.87e-01 -0.036900 8.94e-01
Metal ion SLC transporters 17 7.93e-01 -0.036800 8.95e-01
Cell Cycle 477 1.75e-01 0.036700 4.29e-01
Processing of DNA double-strand break ends 51 6.52e-01 0.036600 8.22e-01
Chondroitin sulfate biosynthesis 10 8.42e-01 -0.036300 9.18e-01
Gluconeogenesis 24 7.60e-01 -0.036000 8.76e-01
SLC-mediated transmembrane transport 114 5.16e-01 -0.035300 7.41e-01
Activation of GABAB receptors 15 8.13e-01 0.035200 9.07e-01
GABA B receptor activation 15 8.13e-01 0.035200 9.07e-01
SUMOylation of DNA replication proteins 39 7.05e-01 -0.035000 8.53e-01
Asparagine N-linked glycosylation 247 3.47e-01 0.034900 6.01e-01
G beta:gamma signalling through CDC42 12 8.34e-01 0.034900 9.18e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 21 7.82e-01 -0.034900 8.90e-01
Regulation of RUNX2 expression and activity 63 6.33e-01 0.034800 8.07e-01
PTEN Regulation 129 4.98e-01 0.034700 7.27e-01
Cell Cycle, Mitotic 388 2.48e-01 0.034500 5.14e-01
Signaling by Hedgehog 108 5.38e-01 -0.034400 7.53e-01
HIV Infection 223 3.92e-01 0.033400 6.43e-01
Mitochondrial Fatty Acid Beta-Oxidation 31 7.48e-01 0.033400 8.71e-01
Activation of gene expression by SREBF (SREBP) 40 7.16e-01 0.033300 8.57e-01
Transferrin endocytosis and recycling 22 7.87e-01 0.033300 8.94e-01
Signaling by NOTCH4 75 6.19e-01 -0.033200 7.98e-01
M Phase 292 3.37e-01 0.032900 5.93e-01
Synthesis of PIPs at the Golgi membrane 14 8.32e-01 -0.032900 9.17e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 41 7.17e-01 0.032800 8.57e-01
Mitotic Prometaphase 151 4.89e-01 -0.032700 7.21e-01
TP53 Regulates Transcription of DNA Repair Genes 60 6.61e-01 0.032700 8.27e-01
HDR through Homologous Recombination (HRR) 50 6.89e-01 0.032700 8.43e-01
Mitotic Anaphase 185 4.49e-01 0.032400 6.86e-01
Mitotic Metaphase and Anaphase 185 4.49e-01 0.032400 6.86e-01
Golgi-to-ER retrograde transport 98 5.81e-01 -0.032400 7.71e-01
Vasopressin regulates renal water homeostasis via Aquaporins 21 8.00e-01 0.031900 9.00e-01
Degradation of GLI1 by the proteasome 56 6.84e-01 0.031500 8.37e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 8.40e-01 0.031100 9.18e-01
RND1 GTPase cycle 27 7.80e-01 0.031000 8.89e-01
DNA Repair 242 4.14e-01 0.030700 6.63e-01
Metabolism 1412 6.35e-02 -0.030600 2.45e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 34 7.58e-01 -0.030500 8.75e-01
Negative regulation of the PI3K/AKT network 56 6.94e-01 -0.030400 8.46e-01
Triglyceride metabolism 20 8.14e-01 -0.030400 9.07e-01
Protein localization 147 5.30e-01 0.030100 7.47e-01
MAPK family signaling cascades 198 4.67e-01 -0.030100 7.01e-01
Regulation of TP53 Activity through Phosphorylation 71 6.62e-01 0.030100 8.27e-01
Nucleotide Excision Repair 104 5.98e-01 0.030000 7.81e-01
Smooth Muscle Contraction 23 8.04e-01 -0.029900 9.04e-01
A tetrasaccharide linker sequence is required for GAG synthesis 11 8.64e-01 0.029800 9.31e-01
Formation of RNA Pol II elongation complex 56 7.01e-01 0.029700 8.52e-01
RNA Polymerase II Transcription Elongation 56 7.01e-01 0.029700 8.52e-01
COPI-mediated anterograde transport 80 6.49e-01 -0.029500 8.20e-01
Processing of Capped Intronless Pre-mRNA 27 7.91e-01 -0.029400 8.95e-01
Resolution of Abasic Sites (AP sites) 33 7.71e-01 0.029300 8.81e-01
Fatty acid metabolism 112 5.94e-01 0.029300 7.81e-01
Ion channel transport 88 6.38e-01 -0.029100 8.11e-01
Apoptosis 145 5.48e-01 0.029000 7.58e-01
TCF dependent signaling in response to WNT 117 5.93e-01 0.028700 7.81e-01
COPI-dependent Golgi-to-ER retrograde traffic 67 6.89e-01 -0.028300 8.43e-01
DNA Damage Recognition in GG-NER 37 7.66e-01 0.028300 8.79e-01
Downstream TCR signaling 84 6.61e-01 -0.027700 8.27e-01
Effects of PIP2 hydrolysis 18 8.39e-01 0.027600 9.18e-01
Formation of Incision Complex in GG-NER 41 7.63e-01 0.027200 8.78e-01
Signaling by NTRK3 (TRKC) 12 8.72e-01 -0.026900 9.35e-01
RHOQ GTPase cycle 45 7.56e-01 -0.026800 8.73e-01
Glycolysis 61 7.24e-01 -0.026200 8.59e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 19 8.44e-01 0.026100 9.18e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 19 8.44e-01 0.026100 9.18e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 19 8.44e-01 0.026100 9.18e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 19 8.44e-01 0.026100 9.18e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 19 8.44e-01 0.026100 9.18e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 10 8.87e-01 0.025800 9.42e-01
Gastrulation 66 7.18e-01 0.025700 8.57e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 8.73e-01 -0.025700 9.35e-01
p53-Dependent G1 DNA Damage Response 58 7.36e-01 0.025700 8.65e-01
p53-Dependent G1/S DNA damage checkpoint 58 7.36e-01 0.025700 8.65e-01
FCERI mediated NF-kB activation 74 7.05e-01 0.025500 8.53e-01
Resolution of D-Loop Structures 22 8.36e-01 0.025500 9.18e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 22 8.36e-01 0.025500 9.18e-01
Signaling by NTRK2 (TRKB) 17 8.56e-01 -0.025400 9.23e-01
Maturation of nucleoprotein 9694631 15 8.69e-01 -0.024700 9.33e-01
APC-Cdc20 mediated degradation of Nek2A 20 8.49e-01 0.024600 9.20e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 21 8.46e-01 -0.024400 9.19e-01
DNA strand elongation 21 8.47e-01 0.024300 9.20e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 10 8.95e-01 0.024100 9.45e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 75 7.19e-01 -0.024000 8.57e-01
Signaling by PDGFRA extracellular domain mutants 12 8.86e-01 0.024000 9.42e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 8.86e-01 0.024000 9.42e-01
Signal amplification 20 8.53e-01 -0.023900 9.21e-01
Regulation of insulin secretion 35 8.10e-01 -0.023500 9.06e-01
Neurexins and neuroligins 21 8.52e-01 0.023500 9.21e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 10 8.98e-01 0.023400 9.46e-01
HDR through MMEJ (alt-NHEJ) 11 8.93e-01 0.023300 9.44e-01
PIP3 activates AKT signaling 198 5.79e-01 0.023000 7.69e-01
Transcriptional Regulation by E2F6 30 8.28e-01 -0.022900 9.16e-01
Keratan sulfate/keratin metabolism 18 8.67e-01 -0.022900 9.32e-01
Gene expression (Transcription) 1074 2.21e-01 -0.022700 4.84e-01
Cytosolic iron-sulfur cluster assembly 10 9.01e-01 -0.022700 9.47e-01
Reproduction 46 7.92e-01 0.022500 8.95e-01
Acyl chain remodelling of PC 10 9.03e-01 0.022400 9.47e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 65 7.56e-01 0.022300 8.73e-01
Amplification of signal from the kinetochores 65 7.56e-01 0.022300 8.73e-01
Muscle contraction 68 7.51e-01 -0.022300 8.72e-01
Interleukin-10 signaling 24 8.51e-01 -0.022100 9.21e-01
Impaired BRCA2 binding to PALB2 18 8.75e-01 0.021400 9.36e-01
RNA Polymerase II Transcription 935 2.91e-01 -0.020900 5.55e-01
Pausing and recovery of Tat-mediated HIV elongation 31 8.44e-01 0.020500 9.18e-01
Tat-mediated HIV elongation arrest and recovery 31 8.44e-01 0.020500 9.18e-01
Hedgehog ‘off’ state 87 7.42e-01 -0.020500 8.66e-01
Deubiquitination 206 6.23e-01 -0.020000 7.99e-01
IRE1alpha activates chaperones 43 8.22e-01 0.019900 9.12e-01
C-type lectin receptors (CLRs) 110 7.21e-01 0.019800 8.57e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 30 8.55e-01 -0.019400 9.22e-01
KEAP1-NFE2L2 pathway 114 7.23e-01 -0.019300 8.58e-01
Processing of SMDT1 14 9.03e-01 0.018900 9.47e-01
Class I MHC mediated antigen processing & presentation 316 5.69e-01 -0.018800 7.67e-01
Defects in vitamin and cofactor metabolism 17 8.94e-01 0.018700 9.44e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 84 7.69e-01 0.018600 8.81e-01
G1/S DNA Damage Checkpoints 59 8.10e-01 0.018200 9.06e-01
DNA Double-Strand Break Repair 105 7.50e-01 -0.018000 8.71e-01
Drug ADME 39 8.48e-01 0.017700 9.20e-01
Host Interactions of HIV factors 129 7.34e-01 -0.017400 8.65e-01
Association of TriC/CCT with target proteins during biosynthesis 30 8.71e-01 -0.017200 9.34e-01
Fatty acyl-CoA biosynthesis 23 8.87e-01 -0.017100 9.42e-01
G2/M Transition 157 7.12e-01 0.017100 8.56e-01
Purine salvage 12 9.18e-01 0.017100 9.60e-01
SUMOylation of chromatin organization proteins 53 8.32e-01 -0.016900 9.17e-01
Transcriptional activation of mitochondrial biogenesis 46 8.44e-01 -0.016700 9.18e-01
Oxidative Stress Induced Senescence 56 8.30e-01 -0.016600 9.17e-01
Cellular Senescence 106 7.71e-01 -0.016400 8.81e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 14 9.20e-01 0.015600 9.60e-01
APC/C:Cdc20 mediated degradation of Cyclin B 20 9.04e-01 0.015500 9.48e-01
Mitotic Prophase 76 8.18e-01 0.015300 9.09e-01
Metabolism of lipids 492 5.67e-01 0.015300 7.66e-01
MTOR signalling 39 8.70e-01 -0.015200 9.34e-01
Fanconi Anemia Pathway 26 8.94e-01 -0.015100 9.44e-01
Mitotic G2-G2/M phases 158 7.45e-01 0.015100 8.68e-01
ECM proteoglycans 17 9.15e-01 -0.014900 9.57e-01
Cytosolic sulfonation of small molecules 11 9.33e-01 -0.014600 9.67e-01
trans-Golgi Network Vesicle Budding 65 8.39e-01 0.014600 9.18e-01
Postmitotic nuclear pore complex (NPC) reformation 25 9.00e-01 0.014500 9.47e-01
RAF/MAP kinase cascade 164 7.54e-01 -0.014200 8.73e-01
Programmed Cell Death 174 7.50e-01 0.014100 8.71e-01
CLEC7A (Dectin-1) signaling 93 8.15e-01 0.014000 9.07e-01
Post-translational protein modification 979 4.69e-01 0.014000 7.01e-01
Transcriptional regulation by RUNX3 86 8.27e-01 0.013700 9.15e-01
Branched-chain amino acid catabolism 21 9.14e-01 0.013700 9.57e-01
Nonhomologous End-Joining (NHEJ) 31 8.96e-01 0.013600 9.45e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 8.66e-01 0.013400 9.32e-01
Cleavage of the damaged purine 10 9.42e-01 0.013400 9.72e-01
Depurination 10 9.42e-01 0.013400 9.72e-01
Recognition and association of DNA glycosylase with site containing an affected purine 10 9.42e-01 0.013400 9.72e-01
Dual Incision in GG-NER 37 8.90e-01 -0.013100 9.44e-01
Transport to the Golgi and subsequent modification 144 7.91e-01 0.012800 8.95e-01
Frs2-mediated activation 10 9.44e-01 0.012800 9.72e-01
Signaling by FGFR2 in disease 25 9.12e-01 0.012700 9.56e-01
Nicotinate metabolism 21 9.21e-01 0.012500 9.60e-01
XBP1(S) activates chaperone genes 41 8.91e-01 0.012400 9.44e-01
Generic Transcription Pathway 823 5.59e-01 -0.012200 7.63e-01
Anchoring of the basal body to the plasma membrane 81 8.53e-01 -0.012000 9.21e-01
Intracellular signaling by second messengers 224 7.70e-01 0.011400 8.81e-01
RND2 GTPase cycle 28 9.19e-01 0.011100 9.60e-01
Disorders of transmembrane transporters 118 8.38e-01 0.010900 9.18e-01
Metabolism of carbohydrates 197 7.95e-01 -0.010800 8.95e-01
SUMOylation of transcription factors 14 9.45e-01 0.010700 9.72e-01
MAPK1/MAPK3 signaling 168 8.16e-01 -0.010500 9.07e-01
WNT5A-dependent internalization of FZD4 12 9.52e-01 -0.010100 9.76e-01
HIV elongation arrest and recovery 32 9.23e-01 -0.009830 9.60e-01
Pausing and recovery of HIV elongation 32 9.23e-01 -0.009830 9.60e-01
RHO GTPases activate PKNs 25 9.33e-01 -0.009680 9.67e-01
Transcriptional regulation by RUNX2 90 8.82e-01 0.009110 9.41e-01
Cohesin Loading onto Chromatin 10 9.60e-01 -0.009090 9.81e-01
Mitotic Telophase/Cytokinesis 10 9.60e-01 -0.009090 9.81e-01
Glucose metabolism 76 8.92e-01 -0.009060 9.44e-01
Signaling by ERBB2 KD Mutants 13 9.55e-01 0.009020 9.79e-01
Signaling by the B Cell Receptor (BCR) 101 8.76e-01 0.009000 9.37e-01
CD28 co-stimulation 27 9.36e-01 -0.008920 9.68e-01
Visual phototransduction 41 9.25e-01 0.008520 9.60e-01
G beta:gamma signalling through BTK 10 9.64e-01 0.008210 9.83e-01
Interleukin-1 signaling 103 8.87e-01 0.008090 9.42e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 50 9.21e-01 0.008090 9.60e-01
ER to Golgi Anterograde Transport 124 8.79e-01 -0.007930 9.39e-01
Metabolic disorders of biological oxidation enzymes 15 9.58e-01 0.007860 9.81e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 10 9.67e-01 -0.007650 9.85e-01
Regulation of TP53 Activity 131 8.83e-01 -0.007470 9.42e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 25 9.49e-01 0.007410 9.75e-01
Cardiac conduction 41 9.35e-01 0.007320 9.68e-01
CD209 (DC-SIGN) signaling 16 9.60e-01 0.007290 9.81e-01
Diseases of programmed cell death 39 9.51e-01 -0.005740 9.76e-01
SUMOylation of DNA damage response and repair proteins 73 9.33e-01 -0.005720 9.67e-01
Signaling by WNT 178 8.97e-01 0.005650 9.45e-01
Transport of small molecules 391 8.85e-01 0.004310 9.42e-01
NCAM signaling for neurite out-growth 22 9.73e-01 -0.004130 9.89e-01
Organelle biogenesis and maintenance 230 9.22e-01 0.003770 9.60e-01
Post-translational modification: synthesis of GPI-anchored proteins 38 9.69e-01 -0.003680 9.86e-01
Transcriptional regulation by RUNX1 139 9.43e-01 -0.003520 9.72e-01
Interleukin-1 family signaling 122 9.47e-01 -0.003510 9.74e-01
MAPK6/MAPK4 signaling 77 9.58e-01 0.003480 9.81e-01
Ion homeostasis 27 9.76e-01 -0.003380 9.90e-01
TNFR2 non-canonical NF-kB pathway 75 9.61e-01 0.003270 9.81e-01
Platelet calcium homeostasis 15 9.83e-01 0.003240 9.93e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 9.79e-01 0.002920 9.91e-01
Nucleotide biosynthesis 11 9.88e-01 -0.002690 9.96e-01
RNA polymerase II transcribes snRNA genes 67 9.73e-01 0.002390 9.89e-01
Transcriptional Regulation by MECP2 38 9.81e-01 -0.002230 9.93e-01
HATs acetylate histones 75 9.74e-01 0.002180 9.89e-01
Scavenging by Class A Receptors 10 9.92e-01 0.001930 9.96e-01
Chromosome Maintenance 73 9.78e-01 -0.001850 9.91e-01
Transcription of E2F targets under negative control by DREAM complex 13 9.91e-01 0.001770 9.96e-01
tRNA processing 112 9.74e-01 0.001760 9.89e-01
Glucagon signaling in metabolic regulation 17 9.91e-01 0.001610 9.96e-01
Glycosphingolipid metabolism 31 9.91e-01 0.001200 9.96e-01
Beta-catenin independent WNT signaling 105 9.84e-01 -0.001140 9.94e-01
DNA Damage/Telomere Stress Induced Senescence 23 9.93e-01 0.001120 9.96e-01
Phospholipid metabolism 143 9.87e-01 0.000763 9.96e-01
Downstream signaling of activated FGFR1 13 9.97e-01 -0.000604 9.99e-01
Signaling by KIT in disease 17 9.98e-01 0.000385 9.99e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 17 9.98e-01 0.000385 9.99e-01
Transcriptional Regulation by TP53 313 9.91e-01 0.000363 9.96e-01
Thromboxane signalling through TP receptor 14 9.99e-01 0.000187 9.99e-01
Biological oxidations 84 9.98e-01 -0.000157 9.99e-01


Detailed Gene set reports



Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
318
set Eukaryotic Translation Elongation
setSize 90
pANOVA 1.07e-35
s.dist -0.76
p.adjustANOVA 3.48e-33



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
EEF1A1 -5022.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
EEF2 -4975.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
RPL13A -4593.0
RPL18A -4587.0
EEF1B2 -4586.0
RPS12 -4347.0
EEF1G -4256.0
RPS2 -4208.0
RPS26 -3765.0
EEF1D -3749.0
RPL9 -525.0
RPL27 59.0
RPS17 280.0
RPL35 449.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
RPSA 5225.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Peptide chain elongation

Peptide chain elongation
746
set Peptide chain elongation
setSize 87
pANOVA 2.36e-34
s.dist -0.757
p.adjustANOVA 6.12e-32



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
EEF1A1 -5022.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
EEF2 -4975.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
RPL13A -4593.0
RPL18A -4587.0
RPS12 -4347.0
RPS2 -4208.0
RPS26 -3765.0
RPL9 -525.0
RPL27 59.0
RPS17 280.0
RPL35 449.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
RPSA 5225.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Viral mRNA Translation

Viral mRNA Translation
1256
set Viral mRNA Translation
setSize 87
pANOVA 3.78e-33
s.dist -0.743
p.adjustANOVA 5.45e-31



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
RPL13A -4593.0
RPL18A -4587.0
RPS12 -4347.0
RPS2 -4208.0
GRSF1 -3825.0
RPS26 -3765.0
RPL9 -525.0
RPL27 59.0
RPS17 280.0
DNAJC3 296.0
RPL35 449.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
RPSA 5225.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
355
set Formation of a pool of free 40S subunits
setSize 98
pANOVA 3.72e-36
s.dist -0.733
p.adjustANOVA 2.38e-33



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
EIF3E -5135.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
EIF3H -4954.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
EIF3G -4926.0
EIF3K -4917.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
EIF3F -4750.0
EIF3L -4734.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
RPL13A -4593.0
RPL18A -4587.0
EIF3D -4565.0
EIF3M -4382.0
RPS12 -4347.0
EIF3A -4263.0
RPS2 -4208.0
RPS26 -3765.0
EIF3B -2664.0
RPL9 -525.0
RPL27 59.0
EIF3J 193.0
RPS17 280.0
EIF3I 337.0
RPL35 449.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
RPSA 5225.0
EIF1AX 5390.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Translocation of ZAP-70 to Immunological synapse

Translocation of ZAP-70 to Immunological synapse
1222
set Translocation of ZAP-70 to Immunological synapse
setSize 10
pANOVA 6.39e-05
s.dist -0.73
p.adjustANOVA 0.00112



Top enriched genes

Top 20 genes
GeneID Gene Rank
HLA-DRB1 -5051
CD4 -5033
HLA-DPA1 -5024
HLA-DPB1 -4938
HLA-DRA -4868
HLA-DQB1 -4026
PTPN22 -3697
HLA-DQA1 -3431
HLA-DRB5 -897
HLA-DQA2 -338

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HLA-DRB1 -5051
CD4 -5033
HLA-DPA1 -5024
HLA-DPB1 -4938
HLA-DRA -4868
HLA-DQB1 -4026
PTPN22 -3697
HLA-DQA1 -3431
HLA-DRB5 -897
HLA-DQA2 -338


SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery
971
set SARS-CoV-1 modulates host translation machinery
setSize 36
pANOVA 7.29e-14
s.dist -0.72
p.adjustANOVA 2.56e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
EEF1A1 -5022.0
RPS3 -5006.0
RPS16 -4978.0
RPS27 -4908.0
RPS7 -4881.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
EEF1A1 -5022.0
RPS3 -5006.0
RPS16 -4978.0
RPS27 -4908.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPS27A -4828.0
RPS28 -4790.0
RPS5 -4730.0
HNRNPA1 -4711.0
RPS4Y1 -4689.0
RPS10 -4640.0
RPS12 -4347.0
RPS2 -4208.0
RPS26 -3765.0
RPS17 280.0
RPS20 3409.0
RPSA 5225.0
RPS19 5504.0
RPS27L 5505.0


L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
542
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 108
pANOVA 5.42e-36
s.dist -0.697
p.adjustANOVA 2.38e-33



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
EIF3E -5135.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
EIF4A2 -5030.0
EIF4B -5015.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
EIF3H -4954.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
EIF3G -4926.0
EIF3K -4917.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
EIF4A1 -4864.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
EIF3F -4750.0
EIF3L -4734.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
PABPC1 -4610.0
RPL13A -4593.0
RPL18A -4587.0
EIF3D -4565.0
EIF2S3 -4531.0
EIF3M -4382.0
RPS12 -4347.0
EIF3A -4263.0
RPS2 -4208.0
RPS26 -3765.0
EIF3B -2664.0
RPL9 -525.0
RPL27 59.0
EIF4E 68.0
EIF3J 193.0
EIF2S1 231.0
RPS17 280.0
EIF3I 337.0
RPL35 449.0
EIF4H 993.0
EIF4G1 1352.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
RPSA 5225.0
EIF2S2 5303.0
EIF1AX 5390.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
396
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 109
pANOVA 5.51e-36
s.dist -0.694
p.adjustANOVA 2.38e-33



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
EIF3E -5135.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
EIF4A2 -5030.0
EIF4B -5015.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
EIF3H -4954.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
EIF3G -4926.0
EIF3K -4917.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
EIF4A1 -4864.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
EIF3F -4750.0
EIF3L -4734.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
RPL13A -4593.0
RPL18A -4587.0
EIF3D -4565.0
EIF2S3 -4531.0
EIF3M -4382.0
RPS12 -4347.0
EIF5 -4270.0
EIF3A -4263.0
RPS2 -4208.0
RPS26 -3765.0
EIF3B -2664.0
EIF5B -1949.0
RPL9 -525.0
RPL27 59.0
EIF4E 68.0
EIF3J 193.0
EIF2S1 231.0
RPS17 280.0
EIF3I 337.0
RPL35 449.0
EIF4H 993.0
EIF4G1 1352.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
RPSA 5225.0
EIF2S2 5303.0
EIF1AX 5390.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Selenocysteine synthesis

Selenocysteine synthesis
1007
set Selenocysteine synthesis
setSize 90
pANOVA 3.05e-29
s.dist -0.684
p.adjustANOVA 3.6e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
RPL13A -4593.0
RPL18A -4587.0
RPS12 -4347.0
RPS2 -4208.0
RPS26 -3765.0
RPL9 -525.0
RPL27 59.0
RPS17 280.0
RPL35 449.0
PSTK 902.0
SEPSECS 1588.0
EEFSEC 2447.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
SECISBP2 3849.0
SEPHS2 4631.0
RPSA 5225.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
987
set SRP-dependent cotranslational protein targeting to membrane
setSize 109
pANOVA 6.35e-34
s.dist -0.673
p.adjustANOVA 1.37e-31



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
SSR4 -5116.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
SEC11A -4915.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
DDOST -4735.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
SPCS2 -4664.0
RPS10 -4640.0
RPL13A -4593.0
RPL18A -4587.0
TRAM1 -4519.0
RPS12 -4347.0
SRP14 -4267.0
SRP9 -4240.0
RPS2 -4208.0
SSR2 -4149.0
SSR3 -4133.0
SRP68 -3935.0
SSR1 -3909.0
SPCS1 -3877.0
RPS26 -3765.0
RPN1 -3284.0
SRPRB -2075.0
SEC61A1 -1684.0
RPL9 -525.0
SEC61B 39.0
RPL27 59.0
RPN2 125.0
SRP19 128.0
SEC61G 184.0
RPS17 280.0
RPL35 449.0
SRP72 496.0
SRPRA 2643.0
SRP54 2762.0
SPCS3 3067.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
SEC11C 5122.0
RPSA 5225.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
688
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 93
pANOVA 3.83e-29
s.dist -0.672
p.adjustANOVA 4.14e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
PABPC1 -4610.0
RPL13A -4593.0
RPL18A -4587.0
RPS12 -4347.0
RPS2 -4208.0
RPS26 -3765.0
RPL9 -525.0
UPF1 -348.0
RPL27 59.0
RPS17 280.0
RPL35 449.0
NCBP2 453.0
EIF4G1 1352.0
NCBP1 1356.0
GSPT2 1662.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
GSPT1 4195.0
ETF1 5110.0
RPSA 5225.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Gap junction assembly

Gap junction assembly
398
set Gap junction assembly
setSize 10
pANOVA 0.000299
s.dist -0.66
p.adjustANOVA 0.00422



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBA1A -4793
TUBA1B -4395
TUBB4A -4232
TUBB3 -3938
TUBB4B -3838
GJB2 -3748
TUBA1C -3663
TUBB2A -2706
TUBA4A -1521
TUBB6 -744

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBA1A -4793
TUBA1B -4395
TUBB4A -4232
TUBB3 -3938
TUBB4B -3838
GJB2 -3748
TUBA1C -3663
TUBB2A -2706
TUBA4A -1521
TUBB6 -744


Transport of connexons to the plasma membrane

Transport of connexons to the plasma membrane
1230
set Transport of connexons to the plasma membrane
setSize 10
pANOVA 0.000299
s.dist -0.66
p.adjustANOVA 0.00422



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBA1A -4793
TUBA1B -4395
TUBB4A -4232
TUBB3 -3938
TUBB4B -3838
GJB2 -3748
TUBA1C -3663
TUBB2A -2706
TUBA4A -1521
TUBB6 -744

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBA1A -4793
TUBA1B -4395
TUBB4A -4232
TUBB3 -3938
TUBB4B -3838
GJB2 -3748
TUBA1C -3663
TUBB2A -2706
TUBA4A -1521
TUBB6 -744


Eukaryotic Translation Termination

Eukaryotic Translation Termination
320
set Eukaryotic Translation Termination
setSize 91
pANOVA 1.57e-27
s.dist -0.659
p.adjustANOVA 1.56e-25



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
RPL13A -4593.0
RPL18A -4587.0
RPS12 -4347.0
RPS2 -4208.0
RPS26 -3765.0
RPL9 -525.0
RPL27 59.0
RPS17 280.0
RPL35 449.0
GSPT2 1662.0
N6AMT1 2390.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
TRMT112 4017.0
GSPT1 4195.0
APEH 4710.0
ETF1 5110.0
RPSA 5225.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
956
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 98
pANOVA 2.97e-29
s.dist -0.656
p.adjustANOVA 3.6e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
CEBPB -4999.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
ATF3 -4821.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
RPL13A -4593.0
RPL18A -4587.0
EIF2S3 -4531.0
RPS12 -4347.0
RPS2 -4208.0
RPS26 -3765.0
ATF2 -2333.0
RPL9 -525.0
GCN1 -43.0
RPL27 59.0
EIF2AK4 121.0
ATF4 188.0
EIF2S1 231.0
RPS17 280.0
IMPACT 385.0
RPL35 449.0
DDIT3 530.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
CEBPG 5218.0
RPSA 5225.0
EIF2S2 5303.0
TRIB3 5398.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Generation of second messenger molecules

Generation of second messenger molecules
408
set Generation of second messenger molecules
setSize 18
pANOVA 1.55e-06
s.dist -0.654
p.adjustANOVA 3.41e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
EVL -5101
HLA-DRB1 -5051
CD4 -5033
HLA-DPA1 -5024
HLA-DPB1 -4938
HLA-DRA -4868
NCK1 -4809
WAS -4341
LAT -4321
HLA-DQB1 -4026
LCP2 -3733
PLCG2 -3576
HLA-DQA1 -3431
PAK2 -2397
VASP -1856
HLA-DRB5 -897
HLA-DQA2 -338
PAK1 3956

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EVL -5101
HLA-DRB1 -5051
CD4 -5033
HLA-DPA1 -5024
HLA-DPB1 -4938
HLA-DRA -4868
NCK1 -4809
WAS -4341
LAT -4321
HLA-DQB1 -4026
LCP2 -3733
PLCG2 -3576
HLA-DQA1 -3431
PAK2 -2397
VASP -1856
HLA-DRB5 -897
HLA-DQA2 -338
PAK1 3956


Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
127
set Cap-dependent Translation Initiation
setSize 116
pANOVA 1.66e-33
s.dist -0.648
p.adjustANOVA 2.69e-31



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
EIF3E -5135.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
EIF4A2 -5030.0
EIF4B -5015.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
EIF3H -4954.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
EIF3G -4926.0
EIF3K -4917.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
EIF4A1 -4864.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
EIF3F -4750.0
EIF3L -4734.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
PABPC1 -4610.0
RPL13A -4593.0
RPL18A -4587.0
EIF3D -4565.0
EIF2S3 -4531.0
EIF3M -4382.0
RPS12 -4347.0
EIF5 -4270.0
EIF3A -4263.0
RPS2 -4208.0
RPS26 -3765.0
EIF2B2 -3634.0
EIF3B -2664.0
EIF5B -1949.0
EIF2B5 -941.0
RPL9 -525.0
RPL27 59.0
EIF4E 68.0
EIF3J 193.0
EIF2S1 231.0
RPS17 280.0
EIF3I 337.0
RPL35 449.0
EIF4H 993.0
EIF2B1 1212.0
EIF4G1 1352.0
RPS20 3409.0
RPL26L1 3450.0
EIF2B4 3556.0
RPL39L 3596.0
EIF2B3 3734.0
EIF4EBP1 4481.0
RPSA 5225.0
EIF2S2 5303.0
EIF1AX 5390.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
319
set Eukaryotic Translation Initiation
setSize 116
pANOVA 1.66e-33
s.dist -0.648
p.adjustANOVA 2.69e-31



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
EIF3E -5135.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
EIF4A2 -5030.0
EIF4B -5015.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
EIF3H -4954.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
EIF3G -4926.0
EIF3K -4917.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
EIF4A1 -4864.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
EIF3F -4750.0
EIF3L -4734.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
PABPC1 -4610.0
RPL13A -4593.0
RPL18A -4587.0
EIF3D -4565.0
EIF2S3 -4531.0
EIF3M -4382.0
RPS12 -4347.0
EIF5 -4270.0
EIF3A -4263.0
RPS2 -4208.0
RPS26 -3765.0
EIF2B2 -3634.0
EIF3B -2664.0
EIF5B -1949.0
EIF2B5 -941.0
RPL9 -525.0
RPL27 59.0
EIF4E 68.0
EIF3J 193.0
EIF2S1 231.0
RPS17 280.0
EIF3I 337.0
RPL35 449.0
EIF4H 993.0
EIF2B1 1212.0
EIF4G1 1352.0
RPS20 3409.0
RPL26L1 3450.0
EIF2B4 3556.0
RPL39L 3596.0
EIF2B3 3734.0
EIF4EBP1 4481.0
RPSA 5225.0
EIF2S2 5303.0
EIF1AX 5390.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
362
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 50
pANOVA 7.22e-15
s.dist -0.636
p.adjustANOVA 2.84e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
EIF3E -5135.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
RPS3 -5006.0
RPS16 -4978.0
EIF3H -4954.0
EIF3G -4926.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
EIF3E -5135.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
RPS3 -5006.0
RPS16 -4978.0
EIF3H -4954.0
EIF3G -4926.0
EIF3K -4917.0
RPS27 -4908.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPS27A -4828.0
RPS28 -4790.0
EIF3F -4750.0
EIF3L -4734.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPS10 -4640.0
EIF3D -4565.0
EIF2S3 -4531.0
EIF3M -4382.0
RPS12 -4347.0
EIF3A -4263.0
RPS2 -4208.0
RPS26 -3765.0
EIF3B -2664.0
EIF3J 193.0
EIF2S1 231.0
RPS17 280.0
EIF3I 337.0
RPS20 3409.0
RPSA 5225.0
EIF2S2 5303.0
EIF1AX 5390.0
RPS19 5504.0
RPS27L 5505.0


Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains
756
set Phosphorylation of CD3 and TCR zeta chains
setSize 14
pANOVA 5.5e-05
s.dist -0.623
p.adjustANOVA 0.000991



Top enriched genes

Top 20 genes
GeneID Gene Rank
HLA-DRB1 -5051
CD4 -5033
HLA-DPA1 -5024
PTPRC -4989
HLA-DPB1 -4938
HLA-DRA -4868
PTPRJ -4236
HLA-DQB1 -4026
PTPN22 -3697
HLA-DQA1 -3431
CSK -2991
HLA-DRB5 -897
HLA-DQA2 -338
PAG1 5358

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HLA-DRB1 -5051
CD4 -5033
HLA-DPA1 -5024
PTPRC -4989
HLA-DPB1 -4938
HLA-DRA -4868
PTPRJ -4236
HLA-DQB1 -4026
PTPN22 -3697
HLA-DQA1 -3431
CSK -2991
HLA-DRB5 -897
HLA-DQA2 -338
PAG1 5358


Translation initiation complex formation

Translation initiation complex formation
1211
set Translation initiation complex formation
setSize 57
pANOVA 6.54e-16
s.dist -0.619
p.adjustANOVA 2.92e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
EIF3E -5135.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
EIF4A2 -5030.0
EIF4B -5015.0
RPS3 -5006.0
RPS16 -4978.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
EIF3E -5135.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
EIF4A2 -5030.0
EIF4B -5015.0
RPS3 -5006.0
RPS16 -4978.0
EIF3H -4954.0
EIF3G -4926.0
EIF3K -4917.0
RPS27 -4908.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
EIF4A1 -4864.0
RPS27A -4828.0
RPS28 -4790.0
EIF3F -4750.0
EIF3L -4734.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPS10 -4640.0
PABPC1 -4610.0
EIF3D -4565.0
EIF2S3 -4531.0
EIF3M -4382.0
RPS12 -4347.0
EIF3A -4263.0
RPS2 -4208.0
RPS26 -3765.0
EIF3B -2664.0
EIF4E 68.0
EIF3J 193.0
EIF2S1 231.0
RPS17 280.0
EIF3I 337.0
EIF4H 993.0
EIF4G1 1352.0
RPS20 3409.0
RPSA 5225.0
EIF2S2 5303.0
EIF1AX 5390.0
RPS19 5504.0
RPS27L 5505.0


Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
964
set Ribosomal scanning and start codon recognition
setSize 57
pANOVA 7.37e-16
s.dist -0.617
p.adjustANOVA 3.19e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
EIF3E -5135.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
EIF4A2 -5030.0
EIF4B -5015.0
RPS3 -5006.0
RPS16 -4978.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
EIF3E -5135.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
EIF4A2 -5030.0
EIF4B -5015.0
RPS3 -5006.0
RPS16 -4978.0
EIF3H -4954.0
EIF3G -4926.0
EIF3K -4917.0
RPS27 -4908.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
EIF4A1 -4864.0
RPS27A -4828.0
RPS28 -4790.0
EIF3F -4750.0
EIF3L -4734.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPS10 -4640.0
EIF3D -4565.0
EIF2S3 -4531.0
EIF3M -4382.0
RPS12 -4347.0
EIF5 -4270.0
EIF3A -4263.0
RPS2 -4208.0
RPS26 -3765.0
EIF3B -2664.0
EIF4E 68.0
EIF3J 193.0
EIF2S1 231.0
RPS17 280.0
EIF3I 337.0
EIF4H 993.0
EIF4G1 1352.0
RPS20 3409.0
RPSA 5225.0
EIF2S2 5303.0
EIF1AX 5390.0
RPS19 5504.0
RPS27L 5505.0


Chaperone Mediated Autophagy

Chaperone Mediated Autophagy
156
set Chaperone Mediated Autophagy
setSize 18
pANOVA 6.15e-06
s.dist -0.616
p.adjustANOVA 0.000131



Top enriched genes

Top 20 genes
GeneID Gene Rank
VIM -5172
UBA52 -5087
EEF1A1 -5022
HSP90AB1 -5012
HSP90AA1 -4994
HSPA8 -4891
UBC -4857
LAMP2 -4848
RPS27A -4828
PLIN2 -4736
RNASE1 -4527
UBB -3600
HDAC6 -3338
PLIN3 -2508
PCNT -1173
IFT88 1716
ARL13B 2136
PARK7 4662

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VIM -5172
UBA52 -5087
EEF1A1 -5022
HSP90AB1 -5012
HSP90AA1 -4994
HSPA8 -4891
UBC -4857
LAMP2 -4848
RPS27A -4828
PLIN2 -4736
RNASE1 -4527
UBB -3600
HDAC6 -3338
PLIN3 -2508
PCNT -1173
IFT88 1716
ARL13B 2136
PARK7 4662


Selenoamino acid metabolism

Selenoamino acid metabolism
1006
set Selenoamino acid metabolism
setSize 101
pANOVA 1.01e-25
s.dist -0.604
p.adjustANOVA 8.23e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
RPL13A -4593.0
RPL18A -4587.0
PAPSS1 -4379.0
RPS12 -4347.0
TXNRD1 -4285.0
RPS2 -4208.0
RPS26 -3765.0
AIMP1 -2804.0
AHCY -1293.0
RPL9 -525.0
RPL27 59.0
RPS17 280.0
RPL35 449.0
GSR 860.0
PSTK 902.0
SCLY 1085.0
SEPSECS 1588.0
AIMP2 1634.0
PAPSS2 2144.0
HNMT 2254.0
EEFSEC 2447.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
SECISBP2 3849.0
SEPHS2 4631.0
CTH 4801.0
RPSA 5225.0
EEF1E1 5372.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
44
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 58
pANOVA 5.09e-15
s.dist -0.594
p.adjustANOVA 2.06e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
EIF3E -5135.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
EIF4A2 -5030.0
EIF4B -5015.0
RPS3 -5006.0
RPS16 -4978.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
EIF3E -5135.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
EIF4A2 -5030.0
EIF4B -5015.0
RPS3 -5006.0
RPS16 -4978.0
EIF3H -4954.0
EIF3G -4926.0
EIF3K -4917.0
RPS27 -4908.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
EIF4A1 -4864.0
RPS27A -4828.0
RPS28 -4790.0
EIF3F -4750.0
EIF3L -4734.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPS10 -4640.0
PABPC1 -4610.0
EIF3D -4565.0
EIF2S3 -4531.0
EIF3M -4382.0
RPS12 -4347.0
EIF3A -4263.0
RPS2 -4208.0
RPS26 -3765.0
EIF3B -2664.0
EIF4E 68.0
EIF3J 193.0
EIF2S1 231.0
RPS17 280.0
EIF3I 337.0
EIF4H 993.0
EIF4G1 1352.0
RPS20 3409.0
EIF4EBP1 4481.0
RPSA 5225.0
EIF2S2 5303.0
EIF1AX 5390.0
RPS19 5504.0
RPS27L 5505.0


FASTK family proteins regulate processing and stability of mitochondrial RNAs

FASTK family proteins regulate processing and stability of mitochondrial RNAs
325
set FASTK family proteins regulate processing and stability of mitochondrial RNAs
setSize 17
pANOVA 3.61e-05
s.dist -0.579
p.adjustANOVA 0.00067



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-CO2 -5083
MT-CO1 -4993
MT-ND4L -4940
MT-ND3 -4827
MT-ND4 -4673
MT-CO3 -4481
MT-ND5 -4384
MT-ND2 -4334
MT-CYB -4301
MT-ATP6 -4235
MT-ND6 -4142
TBRG4 -2759
FASTKD5 -1236
MT-ND1 -930
MT-ATP8 -663
FASTK 2581
FASTKD2 3774

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-CO2 -5083
MT-CO1 -4993
MT-ND4L -4940
MT-ND3 -4827
MT-ND4 -4673
MT-CO3 -4481
MT-ND5 -4384
MT-ND2 -4334
MT-CYB -4301
MT-ATP6 -4235
MT-ND6 -4142
TBRG4 -2759
FASTKD5 -1236
MT-ND1 -930
MT-ATP8 -663
FASTK 2581
FASTKD2 3774


Chemokine receptors bind chemokines

Chemokine receptors bind chemokines
158
set Chemokine receptors bind chemokines
setSize 10
pANOVA 0.00161
s.dist 0.576
p.adjustANOVA 0.0175



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCL3 5503
CCL7 5256
CCL3L1 5214
CCR1 5099
CCL22 4689
CCRL2 4100
CCL2 3543
CXCL16 2122
CCR5 -134
CXCR4 -2863

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCL3 5503
CCL7 5256
CCL3L1 5214
CCR1 5099
CCL22 4689
CCRL2 4100
CCL2 3543
CXCL16 2122
CCR5 -134
CXCR4 -2863


Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
687
set Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize 113
pANOVA 1.13e-25
s.dist -0.571
p.adjustANOVA 8.23e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
PABPC1 -4610.0
RPL13A -4593.0
RPL18A -4587.0
EIF4A3 -4462.0
RPS12 -4347.0
RPS2 -4208.0
PNRC2 -4127.0
RPS26 -3765.0
MAGOH -3237.0
SMG8 -2701.0
SMG6 -2307.0
SMG7 -2091.0
PPP2R2A -1860.0
RNPS1 -1740.0
UPF3A -1225.0
UPF2 -667.0
RPL9 -525.0
UPF1 -348.0
SMG1 -166.0
RPL27 59.0
RBM8A 176.0
RPS17 280.0
RPL35 449.0
NCBP2 453.0
DCP1A 703.0
UPF3B 877.0
EIF4G1 1352.0
NCBP1 1356.0
GSPT2 1662.0
SMG9 1942.0
PPP2CA 2168.0
PPP2R1A 2476.0
SMG5 2873.0
CASC3 3176.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
MAGOHB 3786.0
GSPT1 4195.0
ETF1 5110.0
RPSA 5225.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
689
set Nonsense-Mediated Decay (NMD)
setSize 113
pANOVA 1.13e-25
s.dist -0.571
p.adjustANOVA 8.23e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
PABPC1 -4610.0
RPL13A -4593.0
RPL18A -4587.0
EIF4A3 -4462.0
RPS12 -4347.0
RPS2 -4208.0
PNRC2 -4127.0
RPS26 -3765.0
MAGOH -3237.0
SMG8 -2701.0
SMG6 -2307.0
SMG7 -2091.0
PPP2R2A -1860.0
RNPS1 -1740.0
UPF3A -1225.0
UPF2 -667.0
RPL9 -525.0
UPF1 -348.0
SMG1 -166.0
RPL27 59.0
RBM8A 176.0
RPS17 280.0
RPL35 449.0
NCBP2 453.0
DCP1A 703.0
UPF3B 877.0
EIF4G1 1352.0
NCBP1 1356.0
GSPT2 1662.0
SMG9 1942.0
PPP2CA 2168.0
PPP2R1A 2476.0
SMG5 2873.0
CASC3 3176.0
RPS20 3409.0
RPL26L1 3450.0
RPL39L 3596.0
MAGOHB 3786.0
GSPT1 4195.0
ETF1 5110.0
RPSA 5225.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Post-chaperonin tubulin folding pathway

Post-chaperonin tubulin folding pathway
772
set Post-chaperonin tubulin folding pathway
setSize 14
pANOVA 0.000396
s.dist -0.547
p.adjustANOVA 0.00541



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBA1A -4793
TUBA1B -4395
TUBB4A -4232
TBCA -4176
TUBB3 -3938
TUBB4B -3838
TBCB -3732
TUBA1C -3663
TUBB2A -2706
TUBA4A -1521
TUBB6 -744
TBCD -505
TBCC -403
ARL2 147

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBA1A -4793
TUBA1B -4395
TUBB4A -4232
TBCA -4176
TUBB3 -3938
TUBB4B -3838
TBCB -3732
TUBA1C -3663
TUBB2A -2706
TUBA4A -1521
TUBB6 -744
TBCD -505
TBCC -403
ARL2 147


NOTCH2 Activation and Transmission of Signal to the Nucleus

NOTCH2 Activation and Transmission of Signal to the Nucleus
649
set NOTCH2 Activation and Transmission of Signal to the Nucleus
setSize 16
pANOVA 0.000257
s.dist -0.528
p.adjustANOVA 0.00378



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBA52 -5087
UBC -4857
RPS27A -4828
MDK -4483
NOTCH2 -4442
ADAM10 -4375
NCSTN -4190
UBB -3600
JAG1 -3350
APH1A -3195
PSEN2 -2128
PSEN1 -1604
PSENEN -1158
APH1B 457
MIB1 929
MIB2 3544

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBA52 -5087
UBC -4857
RPS27A -4828
MDK -4483
NOTCH2 -4442
ADAM10 -4375
NCSTN -4190
UBB -3600
JAG1 -3350
APH1A -3195
PSEN2 -2128
PSEN1 -1604
PSENEN -1158
APH1B 457
MIB1 929
MIB2 3544


tRNA processing in the mitochondrion

tRNA processing in the mitochondrion
1295
set tRNA processing in the mitochondrion
setSize 18
pANOVA 0.00011
s.dist -0.526
p.adjustANOVA 0.00186



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-CO2 -5083
MT-CO1 -4993
MT-ND4L -4940
MT-ND3 -4827
MT-ND4 -4673
MT-CO3 -4481
MT-ND5 -4384
MT-ND2 -4334
MT-CYB -4301
MT-ATP6 -4235
MT-ND6 -4142
HSD17B10 -2180
MT-ND1 -930
MT-ATP8 -663
TRMT10C -637
PRORP 605
ELAC2 2939
TRNT1 3744

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-CO2 -5083
MT-CO1 -4993
MT-ND4L -4940
MT-ND3 -4827
MT-ND4 -4673
MT-CO3 -4481
MT-ND5 -4384
MT-ND2 -4334
MT-CYB -4301
MT-ATP6 -4235
MT-ND6 -4142
HSD17B10 -2180
MT-ND1 -930
MT-ATP8 -663
TRMT10C -637
PRORP 605
ELAC2 2939
TRNT1 3744


Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication
486
set Influenza Viral RNA Transcription and Replication
setSize 133
pANOVA 1.14e-25
s.dist -0.526
p.adjustANOVA 8.23e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
HSP90AA1 -4994.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPL36 -4871.0
RPL21 -4859.0
POLR2L -4840.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
RPS10 -4640.0
RPL13A -4593.0
RPL18A -4587.0
RPS12 -4347.0
PARP1 -4226.0
RPS2 -4208.0
POLR2A -4008.0
RANBP2 -3913.0
POLR2E -3855.0
POLR2I -3834.0
GRSF1 -3825.0
RPS26 -3765.0
TPR -3595.0
NUP214 -3569.0
NUP50 -3201.0
NUP133 -3111.0
SEH1L -3010.0
NUP37 -2909.0
NUP58 -2725.0
NUP155 -2515.0
NUP42 -2124.0
POLR2G -1932.0
NDC1 -1892.0
NUP93 -1865.0
NUP98 -1592.0
RAE1 -1032.0
RPL9 -525.0
NUP153 -464.0
POLR2B -223.0
NUP160 -215.0
GTF2F1 -132.0
RPL27 59.0
POLR2K 200.0
GTF2F2 240.0
RPS17 280.0
DNAJC3 296.0
RPL35 449.0
NUP85 780.0
NUP107 941.0
NUP62 1351.0
POLR2H 1405.0
NUP188 1429.0
AAAS 1461.0
POLR2F 1611.0
SEC13 1958.0
NUP205 2205.0
POLR2J 2483.0
NUP43 2484.0
NUP88 2654.0
POLR2C 2764.0
NUP54 3118.0
RPS20 3409.0
RPL26L1 3450.0
NUP210 3555.0
RPL39L 3596.0
POM121 3741.0
IPO5 3945.0
POLR2D 4159.0
POM121C 4439.0
RPSA 5225.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling
347
set Formation of ATP by chemiosmotic coupling
setSize 18
pANOVA 0.000169
s.dist -0.512
p.adjustANOVA 0.00268



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP5MC2 -5155
ATP5F1D -5023
ATP5F1A -4893
ATP5F1E -4763
ATP5ME -4691
ATP5MG -4619
ATP5MF -4346
ATP5MC3 -4299
MT-ATP6 -4235
ATP5F1B -3447
ATP5PD -2030
ATP5F1C -1666
ATP5PO -1438
ATP5PB -1191
MT-ATP8 -663
ATP5MC1 62
DMAC2L 1765
ATP5PF 4500

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5MC2 -5155
ATP5F1D -5023
ATP5F1A -4893
ATP5F1E -4763
ATP5ME -4691
ATP5MG -4619
ATP5MF -4346
ATP5MC3 -4299
MT-ATP6 -4235
ATP5F1B -3447
ATP5PD -2030
ATP5F1C -1666
ATP5PO -1438
ATP5PB -1191
MT-ATP8 -663
ATP5MC1 62
DMAC2L 1765
ATP5PF 4500


Influenza Infection

Influenza Infection
485
set Influenza Infection
setSize 152
pANOVA 1.13e-26
s.dist -0.503
p.adjustANOVA 1.05e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPL10A -5175.0
RPL10 -5173.0
RPL34 -5171.0
RPL26 -5169.0
RPL7A -5168.0
RPL3 -5167.0
RPL32 -5166.0
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPL28 -5158.0
RPS13 -5157.0
RPL11 -5156.0
RPS14 -5154.0
RPL12 -5149.0
RPL30 -5148.0
RPL22 -5144.0
RPL14 -5143.0
RPL5 -5141.0
RPL35A -5136.0
RPS24 -5133.0
RPL7 -5126.0
RPL37 -5113.0
FAU -5112.0
RPL6 -5110.0
RPL18 -5109.0
RPS18 -5106.0
RPS15A -5104.0
RPL29 -5091.0
UBA52 -5087.0
RPS25 -5086.0
RPL36AL -5085.0
RPL24 -5077.0
RPS3A -5073.0
RPS4X -5067.0
RPL41 -5052.0
RPS11 -5048.0
RPS21 -5047.0
RPL17 -5045.0
RPL19 -5039.0
RPS3 -5006.0
HSP90AA1 -4994.0
RPLP2 -4986.0
RPS16 -4978.0
RPL39 -4969.0
RPL37A -4953.0
RPL36A -4947.0
RPL27A -4941.0
RPL38 -4927.0
RPS27 -4908.0
RPL23 -4888.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
CLTA -4877.0
RPL36 -4871.0
RPL21 -4859.0
POLR2L -4840.0
RPS27A -4828.0
RPL15 -4820.0
RPL4 -4816.0
RPL13 -4810.0
RPS28 -4790.0
RPL22L1 -4787.0
RPL23A -4762.0
RPL8 -4759.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPL31 -4675.0
SLC25A6 -4647.0
RPS10 -4640.0
CANX -4629.0
RPL13A -4593.0
RPL18A -4587.0
RPS12 -4347.0
PARP1 -4226.0
RPS2 -4208.0
HSPA1A -4077.0
CALR -4046.0
POLR2A -4008.0
RANBP2 -3913.0
POLR2E -3855.0
POLR2I -3834.0
GRSF1 -3825.0
RPS26 -3765.0
TPR -3595.0
NUP214 -3569.0
PABPN1 -3346.0
NUP50 -3201.0
CLTC -3133.0
NUP133 -3111.0
SEH1L -3010.0
NUP37 -2909.0
NUP58 -2725.0
CPSF4 -2565.0
NUP155 -2515.0
KPNA5 -2442.0
NUP42 -2124.0
POLR2G -1932.0
NDC1 -1892.0
NUP93 -1865.0
ISG15 -1722.0
NUP98 -1592.0
KPNA2 -1478.0
RAE1 -1032.0
RPL9 -525.0
NUP153 -464.0
XPO1 -382.0
POLR2B -223.0
NUP160 -215.0
GTF2F1 -132.0
RAN 4.0
RPL27 59.0
KPNB1 67.0
KPNA4 134.0
POLR2K 200.0
TGFB1 228.0
GTF2F2 240.0
EIF2AK2 244.0
RPS17 280.0
DNAJC3 296.0
RPL35 449.0
NUP85 780.0
NUP107 941.0
NUP62 1351.0
POLR2H 1405.0
NUP188 1429.0
AAAS 1461.0
POLR2F 1611.0
SEC13 1958.0
NUP205 2205.0
POLR2J 2483.0
NUP43 2484.0
KPNA1 2542.0
NUP88 2654.0
POLR2C 2764.0
NUP54 3118.0
RPS20 3409.0
RPL26L1 3450.0
NUP210 3555.0
RPL39L 3596.0
POM121 3741.0
IPO5 3945.0
KPNA3 4106.0
POLR2D 4159.0
POM121C 4439.0
RPSA 5225.0
RPLP0 5496.0
RPLP1 5501.0
RPS19 5504.0
RPS27L 5505.0


SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery
977
set SARS-CoV-2 modulates host translation machinery
setSize 47
pANOVA 2.55e-09
s.dist -0.503
p.adjustANOVA 7.52e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
RPS3 -5006.0
RPS16 -4978.0
RPS27 -4908.0
RPS7 -4881.0
RPS29 -4879.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS9 -5177.5
RPS15 -5164.0
RPS23 -5160.0
RPS8 -5159.0
RPS13 -5157.0
RPS14 -5154.0
RPS24 -5133.0
FAU -5112.0
RPS18 -5106.0
RPS15A -5104.0
RPS25 -5086.0
RPS3A -5073.0
RPS4X -5067.0
RPS11 -5048.0
RPS21 -5047.0
RPS3 -5006.0
RPS16 -4978.0
RPS27 -4908.0
RPS7 -4881.0
RPS29 -4879.0
RPS6 -4878.0
RPS27A -4828.0
RPS28 -4790.0
RPS5 -4730.0
RPS4Y1 -4689.0
RPS10 -4640.0
RPS12 -4347.0
RPS2 -4208.0
SNRPE -3941.0
RPS26 -3765.0
GEMIN5 -3526.0
GEMIN8 -1071.0
SNRPB -969.0
SNRPG 119.0
SNRPD1 149.0
SNRPD2 186.0
RPS17 280.0
SNRPF 382.0
DDX20 1125.0
GEMIN6 1915.0
GEMIN7 3286.0
RPS20 3409.0
GEMIN2 3491.0
SNRPD3 3500.0
RPSA 5225.0
RPS19 5504.0
RPS27L 5505.0


PD-1 signaling

PD-1 signaling
720
set PD-1 signaling
setSize 14
pANOVA 0.00141
s.dist -0.493
p.adjustANOVA 0.0158



Top enriched genes

Top 20 genes
GeneID Gene Rank
HLA-DRB1 -5051
CD4 -5033
HLA-DPA1 -5024
HLA-DPB1 -4938
PTPN6 -4874
HLA-DRA -4868
HLA-DQB1 -4026
HLA-DQA1 -3431
CSK -2991
PDCD1LG2 -1811
HLA-DRB5 -897
HLA-DQA2 -338
PTPN11 3632
CD274 5198

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HLA-DRB1 -5051
CD4 -5033
HLA-DPA1 -5024
HLA-DPB1 -4938
PTPN6 -4874
HLA-DRA -4868
HLA-DQB1 -4026
HLA-DQA1 -3431
CSK -2991
PDCD1LG2 -1811
HLA-DRB5 -897
HLA-DQA2 -338
PTPN11 3632
CD274 5198


Gap junction trafficking

Gap junction trafficking
399
set Gap junction trafficking
setSize 19
pANOVA 0.000208
s.dist -0.492
p.adjustANOVA 0.00315



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLTA -4877
ACTG1 -4865
TUBA1A -4793
TUBA1B -4395
TUBB4A -4232
DAB2 -4066
TUBB3 -3938
TUBB4B -3838
ACTB -3824
GJB2 -3748
TUBA1C -3663
CLTC -3133
TUBB2A -2706
TUBA4A -1521
DNM2 -1004
TUBB6 -744
MYO6 -639
CLTB 4074
AP2M1 5296

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLTA -4877
ACTG1 -4865
TUBA1A -4793
TUBA1B -4395
TUBB4A -4232
DAB2 -4066
TUBB3 -3938
TUBB4B -3838
ACTB -3824
GJB2 -3748
TUBA1C -3663
CLTC -3133
TUBB2A -2706
TUBA4A -1521
DNM2 -1004
TUBB6 -744
MYO6 -639
CLTB 4074
AP2M1 5296


Mitochondrial RNA degradation

Mitochondrial RNA degradation
610
set Mitochondrial RNA degradation
setSize 23
pANOVA 6.15e-05
s.dist -0.483
p.adjustANOVA 0.00109



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-CO2 -5083
MT-CO1 -4993
MT-ND4L -4940
MT-ND3 -4827
MT-ND4 -4673
MT-CO3 -4481
MT-ND5 -4384
MT-ND2 -4334
MT-CYB -4301
MT-ATP6 -4235
MT-ND6 -4142
GRSF1 -3825
SLIRP -3638
LRPPRC -3148
PNPT1 -3059
TBRG4 -2759
FASTKD5 -1236
MT-ND1 -930
MT-ATP8 -663
FASTK 2581

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-CO2 -5083
MT-CO1 -4993
MT-ND4L -4940
MT-ND3 -4827
MT-ND4 -4673
MT-CO3 -4481
MT-ND5 -4384
MT-ND2 -4334
MT-CYB -4301
MT-ATP6 -4235
MT-ND6 -4142
GRSF1 -3825
SLIRP -3638
LRPPRC -3148
PNPT1 -3059
TBRG4 -2759
FASTKD5 -1236
MT-ND1 -930
MT-ATP8 -663
FASTK 2581
REXO2 2625
FASTKD2 3774
SUPV3L1 5355


mRNA decay by 3’ to 5’ exoribonuclease

mRNA decay by 3’ to 5’ exoribonuclease
1275
set mRNA decay by 3’ to 5’ exoribonuclease
setSize 13
pANOVA 0.00264
s.dist 0.482
p.adjustANOVA 0.0259



Top enriched genes

Top 20 genes
GeneID Gene Rank
NT5C3B 5367
EXOSC8 4920
EXOSC9 3884
EXOSC6 3755
EXOSC1 3396
DCPS 3386
EXOSC5 2898
EXOSC4 2603
EXOSC7 2512
EXOSC3 2302
EXOSC2 1906
HBS1L 1204
DIS3 -2409

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NT5C3B 5367
EXOSC8 4920
EXOSC9 3884
EXOSC6 3755
EXOSC1 3396
DCPS 3386
EXOSC5 2898
EXOSC4 2603
EXOSC7 2512
EXOSC3 2302
EXOSC2 1906
HBS1L 1204
DIS3 -2409


TICAM1,TRAF6-dependent induction of TAK1 complex

TICAM1,TRAF6-dependent induction of TAK1 complex
1141
set TICAM1,TRAF6-dependent induction of TAK1 complex
setSize 10
pANOVA 0.00856
s.dist -0.48
p.adjustANOVA 0.0638



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBA52 -5087
UBC -4857
RPS27A -4828
UBB -3600
TAB3 -3020
TICAM1 -2549
TAB2 -1231
TAB1 -722
MAP3K7 -212
TRAF6 2162

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBA52 -5087
UBC -4857
RPS27A -4828
UBB -3600
TAB3 -3020
TICAM1 -2549
TAB2 -1231
TAB1 -722
MAP3K7 -212
TRAF6 2162


Plasma lipoprotein assembly

Plasma lipoprotein assembly
758
set Plasma lipoprotein assembly
setSize 11
pANOVA 0.00637
s.dist -0.475
p.adjustANOVA 0.0533



Top enriched genes

Top 20 genes
GeneID Gene Rank
APOE -5140
APOC1 -4964
APOC2 -4333
PRKACB -4194
P4HB -3573
APOC4 -2231
PRKACA -2157
ZDHHC8 -1873
ABCA1 -1337
A2M 26
SAR1B 3737

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOE -5140
APOC1 -4964
APOC2 -4333
PRKACB -4194
P4HB -3573
APOC4 -2231
PRKACA -2157
ZDHHC8 -1873
ABCA1 -1337
A2M 26
SAR1B 3737


Negative regulation of FLT3

Negative regulation of FLT3
667
set Negative regulation of FLT3
setSize 11
pANOVA 0.00655
s.dist -0.474
p.adjustANOVA 0.0539



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBA52 -5087
UBC -4857
RPS27A -4828
PTPRJ -4236
UBB -3600
CBL -3052
CSK -2991
SOCS6 -2371
ABL2 389
SH2B3 522
SLA 4168

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBA52 -5087
UBC -4857
RPS27A -4828
PTPRJ -4236
UBB -3600
CBL -3052
CSK -2991
SOCS6 -2371
ABL2 389
SH2B3 522
SLA 4168


TICAM1-dependent activation of IRF3/IRF7

TICAM1-dependent activation of IRF3/IRF7
1142
set TICAM1-dependent activation of IRF3/IRF7
setSize 11
pANOVA 0.00665
s.dist -0.473
p.adjustANOVA 0.0539



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBA52 -5087
UBC -4857
RPS27A -4828
UBB -3600
IRF7 -3548
IKBKE -3466
TICAM1 -2549
TRAF3 -1183
TANK 481
TBK1 690
IRF3 2055

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBA52 -5087
UBC -4857
RPS27A -4828
UBB -3600
IRF7 -3548
IKBKE -3466
TICAM1 -2549
TRAF3 -1183
TANK 481
TBK1 690
IRF3 2055


APOBEC3G mediated resistance to HIV-1 infection

APOBEC3G mediated resistance to HIV-1 infection
18
set APOBEC3G mediated resistance to HIV-1 infection
setSize 10
pANOVA 0.01
s.dist 0.47
p.adjustANOVA 0.0711



Top enriched genes

Top 20 genes
GeneID Gene Rank
gag 5519
vif 5519
vpr 5519
vpu 5519
rev 5509
HMGA1 4911
APOBEC3G 1618
PSIP1 981
BANF1 -3465
PPIA -4755

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
gag 5519
vif 5519
vpr 5519
vpu 5519
rev 5509
HMGA1 4911
APOBEC3G 1618
PSIP1 981
BANF1 -3465
PPIA -4755


Gap junction trafficking and regulation

Gap junction trafficking and regulation
400
set Gap junction trafficking and regulation
setSize 21
pANOVA 0.000228
s.dist -0.465
p.adjustANOVA 0.00339



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLTA -4877
ACTG1 -4865
TUBA1A -4793
TUBA1B -4395
TUBB4A -4232
DAB2 -4066
TUBB3 -3938
TUBB4B -3838
ACTB -3824
GJB2 -3748
TUBA1C -3663
CLTC -3133
SRC -2845
TUBB2A -2706
TUBA4A -1521
DNM2 -1004
TUBB6 -744
MYO6 -639
TJP1 962
CLTB 4074

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLTA -4877
ACTG1 -4865
TUBA1A -4793
TUBA1B -4395
TUBB4A -4232
DAB2 -4066
TUBB3 -3938
TUBB4B -3838
ACTB -3824
GJB2 -3748
TUBA1C -3663
CLTC -3133
SRC -2845
TUBB2A -2706
TUBA4A -1521
DNM2 -1004
TUBB6 -744
MYO6 -639
TJP1 962
CLTB 4074
AP2M1 5296


NF-kB is activated and signals survival

NF-kB is activated and signals survival
643
set NF-kB is activated and signals survival
setSize 11
pANOVA 0.01
s.dist -0.448
p.adjustANOVA 0.0711



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBA52 -5087
UBC -4857
RPS27A -4828
SQSTM1 -4797
NFKBIA -3905
UBB -3600
RELA -2327
IKBKB -1324
NFKB1 898
TRAF6 2162
IRAK1 3196

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBA52 -5087
UBC -4857
RPS27A -4828
SQSTM1 -4797
NFKBIA -3905
UBB -3600
RELA -2327
IKBKB -1324
NFKB1 898
TRAF6 2162
IRAK1 3196


Amyloid fiber formation

Amyloid fiber formation
56
set Amyloid fiber formation
setSize 32
pANOVA 1.36e-05
s.dist -0.444
p.adjustANOVA 0.000276



Top enriched genes

Top 20 genes
GeneID Gene Rank
CST3 -5177.5
APOE -5140.0
LYZ -5128.0
UBA52 -5087.0
ITM2B -4991.0
B2M -4968.0
UBC -4857.0
RPS27A -4828.0
TGFBI -4796.0
GSN -4591.0
TSPAN33 -4580.0
TSPAN14 -4529.0
ADAM10 -4375.0
SORL1 -4209.0
NCSTN -4190.0
TSPAN15 -3730.0
UBB -3600.0
APP -3572.0
APH1A -3195.0
FURIN -3027.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CST3 -5177.5
APOE -5140.0
LYZ -5128.0
UBA52 -5087.0
ITM2B -4991.0
B2M -4968.0
UBC -4857.0
RPS27A -4828.0
TGFBI -4796.0
GSN -4591.0
TSPAN33 -4580.0
TSPAN14 -4529.0
ADAM10 -4375.0
SORL1 -4209.0
NCSTN -4190.0
TSPAN15 -3730.0
UBB -3600.0
APP -3572.0
APH1A -3195.0
FURIN -3027.0
SIAH1 -2426.0
GGA3 -1836.0
PSENEN -1158.0
USP9X 216.0
APH1B 457.0
GGA1 1017.0
UBE2L6 2195.0
BACE1 2595.0
H2AFX 3428.0
GGA2 3776.0
SIAH2 4466.0
SNCA 5494.0


Metabolism of folate and pterines

Metabolism of folate and pterines
589
set Metabolism of folate and pterines
setSize 14
pANOVA 0.0042
s.dist 0.442
p.adjustANOVA 0.0373



Top enriched genes

Top 20 genes
GeneID Gene Rank
ALDH1L2 5352
MTHFD1L 5306
MTHFD2 4943
SHMT1 4921
SHMT2 4830
SLC25A32 4525
DHFR2 4249
MTHFS 4099
DHFR 3669
MTHFD2L 1468
MTHFR -455
MTHFD1 -549
FPGS -1797
FOLR2 -5068

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALDH1L2 5352
MTHFD1L 5306
MTHFD2 4943
SHMT1 4921
SHMT2 4830
SLC25A32 4525
DHFR2 4249
MTHFS 4099
DHFR 3669
MTHFD2L 1468
MTHFR -455
MTHFD1 -549
FPGS -1797
FOLR2 -5068


NGF-stimulated transcription

NGF-stimulated transcription
645
set NGF-stimulated transcription
setSize 25
pANOVA 0.000157
s.dist -0.437
p.adjustANOVA 0.00251



Top enriched genes

Top 20 genes
GeneID Gene Rank
JUNB -5163
EGR2 -4939
JUND -4933
ID2 -4849
SGK1 -4847
FOS -4526
CHD4 -4459
TRIB1 -4252
MEF2D -4015
ID3 -3850
EP300 -3001
TCF12 -2536
F3 -2411
LYL1 -2367
ATF2 -2333
REST -2179
ATF1 -2096
NAB2 -1616
CREB1 -1112
DNM2 -1004

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
JUNB -5163
EGR2 -4939
JUND -4933
ID2 -4849
SGK1 -4847
FOS -4526
CHD4 -4459
TRIB1 -4252
MEF2D -4015
ID3 -3850
EP300 -3001
TCF12 -2536
F3 -2411
LYL1 -2367
ATF2 -2333
REST -2179
ATF1 -2096
NAB2 -1616
CREB1 -1112
DNM2 -1004
CDK5 615
SRF 716
NAB1 1369
ELK1 4711
FOSL1 5086


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] stringr_1.5.0        harmony_0.1.1        Rcpp_1.0.11         
##  [4] tidyr_1.3.0          SeuratWrappers_0.3.1 SeuratObject_4.1.3  
##  [7] Seurat_4.3.0.1       pkgload_1.3.2.1      GGally_2.1.2        
## [10] ggplot2_3.4.3        reshape2_1.4.4       beeswarm_0.4.0      
## [13] gtools_3.9.4         tibble_3.2.1         dplyr_1.1.3         
## [16] echarts4r_0.4.5      kableExtra_1.3.4     gplots_3.1.3        
## [19] mitch_1.12.0        
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3     rstudioapi_0.15.0      jsonlite_1.8.7        
##   [4] magrittr_2.0.3         spatstat.utils_3.0-3   farver_2.1.1          
##   [7] rmarkdown_2.25         vctrs_0.6.3            ROCR_1.0-11           
##  [10] spatstat.explore_3.2-3 webshot_0.5.5          htmltools_0.5.6       
##  [13] sass_0.4.7             sctransform_0.3.5      parallelly_1.36.0     
##  [16] KernSmooth_2.23-22     bslib_0.5.1            htmlwidgets_1.6.2     
##  [19] ica_1.0-3              plyr_1.8.8             plotly_4.10.2         
##  [22] zoo_1.8-12             cachem_1.0.8           igraph_1.5.1          
##  [25] mime_0.12              lifecycle_1.0.3        pkgconfig_2.0.3       
##  [28] rsvd_1.0.5             Matrix_1.6-1.1         R6_2.5.1              
##  [31] fastmap_1.1.1          fitdistrplus_1.1-11    future_1.33.0         
##  [34] shiny_1.7.5            digest_0.6.33          colorspace_2.1-0      
##  [37] reshape_0.8.9          patchwork_1.1.3        tensor_1.5            
##  [40] irlba_2.3.5.1          labeling_0.4.3         progressr_0.14.0      
##  [43] fansi_1.0.4            spatstat.sparse_3.0-2  httr_1.4.7            
##  [46] polyclip_1.10-4        abind_1.4-5            compiler_4.3.1        
##  [49] remotes_2.4.2.1        withr_2.5.0            highr_0.10            
##  [52] R.utils_2.12.2         MASS_7.3-60            caTools_1.18.2        
##  [55] tools_4.3.1            lmtest_0.9-40          httpuv_1.6.11         
##  [58] future.apply_1.11.0    goftest_1.2-3          R.oo_1.25.0           
##  [61] glue_1.6.2             nlme_3.1-163           promises_1.2.1        
##  [64] grid_4.3.1             Rtsne_0.16             cluster_2.1.4         
##  [67] generics_0.1.3         gtable_0.3.4           spatstat.data_3.0-1   
##  [70] R.methodsS3_1.8.2      data.table_1.14.8      sp_2.0-0              
##  [73] xml2_1.3.5             utf8_1.2.3             spatstat.geom_3.2-5   
##  [76] RcppAnnoy_0.0.21       ggrepel_0.9.3          RANN_2.6.1            
##  [79] pillar_1.9.0           later_1.3.1            splines_4.3.1         
##  [82] lattice_0.21-8         survival_3.5-7         deldir_1.0-9          
##  [85] tidyselect_1.2.0       miniUI_0.1.1.1         pbapply_1.7-2         
##  [88] knitr_1.44             gridExtra_2.3          svglite_2.1.1         
##  [91] scattermore_1.2        xfun_0.40              matrixStats_1.0.0     
##  [94] stringi_1.7.12         lazyeval_0.2.2         yaml_2.3.7            
##  [97] evaluate_0.21          codetools_0.2-19       BiocManager_1.30.22   
## [100] cli_3.6.1              uwot_0.1.16            xtable_1.8-4          
## [103] reticulate_1.32.0      systemfonts_1.0.4      munsell_0.5.0         
## [106] jquerylib_0.1.4        globals_0.16.2         spatstat.random_3.1-6 
## [109] png_0.1-8              parallel_4.3.1         ellipsis_0.3.2        
## [112] bitops_1.0-7           listenv_0.9.0          viridisLite_0.4.2     
## [115] scales_1.2.1           ggridges_0.5.4         leiden_0.4.3          
## [118] purrr_1.0.2            rlang_1.1.1            cowplot_1.1.1         
## [121] rvest_1.0.3

END of report