Mitch Report

date generated: 2023-09-22

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
env	260.9277
gag	260.9277
pol	260.9277
vif	260.9277
tat	260.9277
vpu	260.9277

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2630
num_genes_in_profile	10713
duplicated_genes_present	0
num_profile_genes_in_sets	6214
num_profile_genes_not_in_sets	4499

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-20.gmt

Gene set metrics

	Gene sets metrics
num_genesets	2630
num_genesets_excluded	1335
num_genesets_included	1295

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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set	setSize	pANOVA	s.dist	p.adjustANOVA
Peptide chain elongation	87	1.72e-30	-0.711	4.45e-28
Eukaryotic Translation Elongation	90	6.54e-31	-0.704	2.12e-28
Viral mRNA Translation	87	1.78e-29	-0.699	2.89e-27
Translocation of ZAP-70 to Immunological synapse	10	1.37e-04	-0.697	2.11e-03
Formation of a pool of free 40S subunits	98	9.60e-32	-0.685	6.26e-29
SARS-CoV-1 modulates host translation machinery	36	1.92e-12	-0.678	7.75e-11
L13a-mediated translational silencing of Ceruloplasmin expression	108	9.67e-32	-0.653	6.26e-29
GTP hydrolysis and joining of the 60S ribosomal subunit	109	2.24e-31	-0.646	9.65e-29
Selenocysteine synthesis	90	9.67e-26	-0.639	1.14e-23
Generation of second messenger molecules	18	2.70e-06	-0.639	6.73e-05
FASTK family proteins regulate processing and stability of mitochondrial RNAs	17	5.18e-06	-0.638	1.27e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	8.92e-26	-0.630	1.14e-23
Chemokine receptors bind chemokines	10	6.62e-04	0.622	8.10e-03
SRP-dependent cotranslational protein targeting to membrane	109	7.47e-29	-0.618	1.07e-26
Eukaryotic Translation Termination	91	2.37e-24	-0.618	2.36e-22
tRNA processing in the mitochondrion	18	6.92e-06	-0.612	1.66e-04
Phosphorylation of CD3 and TCR zeta chains	14	7.42e-05	-0.612	1.32e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency	98	1.63e-25	-0.610	1.76e-23
Cap-dependent Translation Initiation	116	1.32e-29	-0.607	2.45e-27
Eukaryotic Translation Initiation	116	1.32e-29	-0.607	2.45e-27
Formation of the ternary complex, and subsequently, the 43S complex	50	5.67e-13	-0.589	2.45e-11
Translation initiation complex formation	57	4.70e-14	-0.577	2.65e-12
Ribosomal scanning and start codon recognition	57	5.73e-14	-0.575	3.09e-12
Selenoamino acid metabolism	101	1.38e-22	-0.563	1.27e-20
Chaperone Mediated Autophagy	18	4.23e-05	-0.558	8.56e-04
mRNA decay by 3’ to 5’ exoribonuclease	13	5.14e-04	0.556	6.46e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	58	3.48e-13	-0.552	1.61e-11
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	2.16e-22	-0.530	1.75e-20
Nonsense-Mediated Decay (NMD)	113	2.16e-22	-0.530	1.75e-20
APOBEC3G mediated resistance to HIV-1 infection	10	4.67e-03	0.517	3.51e-02
Negative regulation of FLT3	11	3.55e-03	-0.508	2.99e-02
Mitochondrial RNA degradation	23	3.01e-05	-0.503	6.29e-04
NOTCH2 Activation and Transmission of Signal to the Nucleus	16	6.63e-04	-0.492	8.10e-03
Negative regulation of MET activity	16	1.00e-03	-0.475	1.13e-02
Influenza Viral RNA Transcription and Replication	133	3.53e-21	-0.475	2.54e-19
HDMs demethylate histones	21	1.71e-04	-0.474	2.58e-03
PD-1 signaling	14	2.34e-03	-0.470	2.13e-02
Caspase-mediated cleavage of cytoskeletal proteins	10	1.03e-02	-0.468	5.99e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	7.22e-03	-0.468	4.84e-02
Complement cascade	18	6.27e-04	-0.466	7.80e-03
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	1.12e-02	-0.463	6.31e-02
InlB-mediated entry of Listeria monocytogenes into host cell	12	5.70e-03	-0.461	4.06e-02
TICAM1,TRAF6-dependent induction of TAK1 complex	10	1.17e-02	-0.460	6.53e-02
Signaling by NOTCH2	24	1.27e-04	-0.452	1.98e-03
Influenza Infection	152	2.69e-21	-0.446	2.05e-19
NGF-stimulated transcription	25	1.24e-04	-0.444	1.96e-03
SARS-CoV-2 modulates host translation machinery	47	1.55e-07	-0.443	4.28e-06
Other semaphorin interactions	11	1.13e-02	-0.441	6.34e-02
Antimicrobial peptides	15	3.77e-03	-0.432	3.06e-02
Gap junction trafficking	18	1.59e-03	-0.430	1.64e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Peptide chain elongation	87	1.72e-30	-0.711000	4.45e-28
Eukaryotic Translation Elongation	90	6.54e-31	-0.704000	2.12e-28
Viral mRNA Translation	87	1.78e-29	-0.699000	2.89e-27
Translocation of ZAP-70 to Immunological synapse	10	1.37e-04	-0.697000	2.11e-03
Formation of a pool of free 40S subunits	98	9.60e-32	-0.685000	6.26e-29
SARS-CoV-1 modulates host translation machinery	36	1.92e-12	-0.678000	7.75e-11
L13a-mediated translational silencing of Ceruloplasmin expression	108	9.67e-32	-0.653000	6.26e-29
GTP hydrolysis and joining of the 60S ribosomal subunit	109	2.24e-31	-0.646000	9.65e-29
Selenocysteine synthesis	90	9.67e-26	-0.639000	1.14e-23
Generation of second messenger molecules	18	2.70e-06	-0.639000	6.73e-05
FASTK family proteins regulate processing and stability of mitochondrial RNAs	17	5.18e-06	-0.638000	1.27e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	8.92e-26	-0.630000	1.14e-23
Chemokine receptors bind chemokines	10	6.62e-04	0.622000	8.10e-03
SRP-dependent cotranslational protein targeting to membrane	109	7.47e-29	-0.618000	1.07e-26
Eukaryotic Translation Termination	91	2.37e-24	-0.618000	2.36e-22
tRNA processing in the mitochondrion	18	6.92e-06	-0.612000	1.66e-04
Phosphorylation of CD3 and TCR zeta chains	14	7.42e-05	-0.612000	1.32e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency	98	1.63e-25	-0.610000	1.76e-23
Cap-dependent Translation Initiation	116	1.32e-29	-0.607000	2.45e-27
Eukaryotic Translation Initiation	116	1.32e-29	-0.607000	2.45e-27
Formation of the ternary complex, and subsequently, the 43S complex	50	5.67e-13	-0.589000	2.45e-11
Translation initiation complex formation	57	4.70e-14	-0.577000	2.65e-12
Ribosomal scanning and start codon recognition	57	5.73e-14	-0.575000	3.09e-12
Selenoamino acid metabolism	101	1.38e-22	-0.563000	1.27e-20
Chaperone Mediated Autophagy	18	4.23e-05	-0.558000	8.56e-04
mRNA decay by 3’ to 5’ exoribonuclease	13	5.14e-04	0.556000	6.46e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	58	3.48e-13	-0.552000	1.61e-11
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	2.16e-22	-0.530000	1.75e-20
Nonsense-Mediated Decay (NMD)	113	2.16e-22	-0.530000	1.75e-20
APOBEC3G mediated resistance to HIV-1 infection	10	4.67e-03	0.517000	3.51e-02
Negative regulation of FLT3	11	3.55e-03	-0.508000	2.99e-02
Mitochondrial RNA degradation	23	3.01e-05	-0.503000	6.29e-04
NOTCH2 Activation and Transmission of Signal to the Nucleus	16	6.63e-04	-0.492000	8.10e-03
Negative regulation of MET activity	16	1.00e-03	-0.475000	1.13e-02
Influenza Viral RNA Transcription and Replication	133	3.53e-21	-0.475000	2.54e-19
HDMs demethylate histones	21	1.71e-04	-0.474000	2.58e-03
PD-1 signaling	14	2.34e-03	-0.470000	2.13e-02
Caspase-mediated cleavage of cytoskeletal proteins	10	1.03e-02	-0.468000	5.99e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	7.22e-03	-0.468000	4.84e-02
Complement cascade	18	6.27e-04	-0.466000	7.80e-03
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	10	1.12e-02	-0.463000	6.31e-02
InlB-mediated entry of Listeria monocytogenes into host cell	12	5.70e-03	-0.461000	4.06e-02
TICAM1,TRAF6-dependent induction of TAK1 complex	10	1.17e-02	-0.460000	6.53e-02
Signaling by NOTCH2	24	1.27e-04	-0.452000	1.98e-03
Influenza Infection	152	2.69e-21	-0.446000	2.05e-19
NGF-stimulated transcription	25	1.24e-04	-0.444000	1.96e-03
SARS-CoV-2 modulates host translation machinery	47	1.55e-07	-0.443000	4.28e-06
Other semaphorin interactions	11	1.13e-02	-0.441000	6.34e-02
Antimicrobial peptides	15	3.77e-03	-0.432000	3.06e-02
Gap junction trafficking	18	1.59e-03	-0.430000	1.64e-02
NF-kB is activated and signals survival	11	1.37e-02	-0.429000	7.36e-02
Alpha-protein kinase 1 signaling pathway	11	1.40e-02	-0.428000	7.47e-02
Formation of ATP by chemiosmotic coupling	18	2.22e-03	-0.417000	2.05e-02
Binding and entry of HIV virion	11	1.80e-02	0.412000	9.08e-02
Regulation of Complement cascade	16	5.18e-03	-0.404000	3.77e-02
Cell death signalling via NRAGE, NRIF and NADE	52	5.71e-07	-0.401000	1.48e-05
Infection with Mycobacterium tuberculosis	24	7.40e-04	-0.398000	8.79e-03
Gap junction trafficking and regulation	20	2.29e-03	-0.394000	2.10e-02
SARS-CoV-1-host interactions	88	1.88e-10	-0.393000	6.26e-09
Post-chaperonin tubulin folding pathway	14	1.10e-02	-0.392000	6.25e-02
Downregulation of ERBB2 signaling	18	4.07e-03	-0.391000	3.15e-02
Signaling by Erythropoietin	23	1.22e-03	-0.390000	1.32e-02
Semaphorin interactions	44	8.29e-06	-0.389000	1.95e-04
RHOBTB GTPase Cycle	33	1.21e-04	-0.387000	1.94e-03
NRAGE signals death through JNK	35	7.61e-05	-0.387000	1.33e-03
Apoptotic cleavage of cellular proteins	25	8.54e-04	-0.385000	9.87e-03
IRAK2 mediated activation of TAK1 complex	10	3.67e-02	-0.382000	1.47e-01
rRNA processing in the mitochondrion	21	2.58e-03	-0.380000	2.32e-02
Interleukin-15 signaling	11	3.03e-02	-0.377000	1.26e-01
RHOBTB2 GTPase cycle	22	2.22e-03	-0.377000	2.05e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus	18	6.47e-03	-0.371000	4.48e-02
ALK mutants bind TKIs	12	2.63e-02	-0.370000	1.16e-01
Cellular response to starvation	143	2.73e-14	-0.369000	1.61e-12
Response of Mtb to phagocytosis	21	3.46e-03	-0.369000	2.93e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	12	2.75e-02	-0.368000	1.19e-01
Sema4D in semaphorin signaling	16	1.17e-02	-0.364000	6.53e-02
2-LTR circle formation	12	2.95e-02	0.363000	1.24e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	16	1.24e-02	-0.361000	6.83e-02
Signaling by Ligand-Responsive EGFR Variants in Cancer	16	1.24e-02	-0.361000	6.83e-02
GPVI-mediated activation cascade	27	1.23e-03	-0.359000	1.32e-02
DAP12 signaling	22	3.61e-03	-0.359000	3.02e-02
Amyloid fiber formation	32	4.70e-04	-0.357000	5.97e-03
Cell-extracellular matrix interactions	13	2.67e-02	-0.355000	1.17e-01
Attachment and Entry 9694614	10	5.23e-02	-0.355000	1.86e-01
Plasma lipoprotein assembly	11	4.38e-02	-0.351000	1.66e-01
Constitutive Signaling by Aberrant PI3K in Cancer	25	2.41e-03	-0.351000	2.18e-02
p75NTR signals via NF-kB	14	2.42e-02	-0.348000	1.08e-01
Rap1 signalling	12	3.79e-02	-0.346000	1.51e-01
NOTCH3 Intracellular Domain Regulates Transcription	16	1.71e-02	-0.344000	8.81e-02
M-decay: degradation of maternal mRNAs by maternally stored factors	37	2.97e-04	-0.344000	3.92e-03
Listeria monocytogenes entry into host cells	17	1.42e-02	-0.344000	7.50e-02
Signaling by NOTCH3	33	6.70e-04	-0.342000	8.11e-03
Suppression of phagosomal maturation	12	4.03e-02	-0.342000	1.58e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	29	1.49e-03	-0.341000	1.55e-02
RHO GTPases Activate NADPH Oxidases	19	1.01e-02	-0.341000	5.95e-02
Deadenylation of mRNA	21	7.08e-03	-0.340000	4.83e-02
Interleukin-2 family signaling	30	1.31e-03	-0.339000	1.38e-02
RHO GTPases activate IQGAPs	22	5.96e-03	-0.339000	4.15e-02
Signaling by CSF1 (M-CSF) in myeloid cells	28	1.94e-03	-0.339000	1.87e-02
Diseases of carbohydrate metabolism	24	4.15e-03	-0.338000	3.20e-02
Sensory processing of sound	29	1.67e-03	-0.337000	1.67e-02
Recycling pathway of L1	32	9.85e-04	-0.337000	1.13e-02
G alpha (12/13) signalling events	45	9.80e-05	-0.336000	1.63e-03
Metabolism of folate and pterines	14	2.99e-02	0.335000	1.25e-01
Sema4D induced cell migration and growth-cone collapse	13	3.68e-02	-0.334000	1.47e-01
RHOBTB1 GTPase cycle	21	8.03e-03	-0.334000	5.28e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling	38	4.13e-04	-0.331000	5.34e-03
Mitochondrial iron-sulfur cluster biogenesis	13	4.05e-02	0.328000	1.58e-01
RHO GTPases Activate WASPs and WAVEs	34	9.97e-04	-0.326000	1.13e-02
Regulation of actin dynamics for phagocytic cup formation	55	2.92e-05	-0.326000	6.19e-04
Pexophagy	10	7.45e-02	-0.326000	2.29e-01
EPH-ephrin mediated repulsion of cells	27	3.41e-03	-0.326000	2.91e-02
Regulation of signaling by CBL	21	1.03e-02	-0.324000	5.98e-02
FCGR3A-mediated phagocytosis	52	6.41e-05	-0.321000	1.19e-03
Leishmania phagocytosis	52	6.41e-05	-0.321000	1.19e-03
Parasite infection	52	6.41e-05	-0.321000	1.19e-03
NRIF signals cell death from the nucleus	14	3.84e-02	-0.320000	1.52e-01
Signaling by ALK fusions and activated point mutants	50	9.45e-05	-0.319000	1.59e-03
Signaling by ALK in cancer	50	9.45e-05	-0.319000	1.59e-03
Regulation of beta-cell development	16	2.70e-02	-0.319000	1.17e-01
Assembly of collagen fibrils and other multimeric structures	17	2.42e-02	-0.316000	1.08e-01
Signaling by ROBO receptors	184	1.96e-13	-0.315000	9.75e-12
Constitutive Signaling by NOTCH1 HD Domain Mutants	10	8.44e-02	-0.315000	2.47e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	10	8.44e-02	-0.315000	2.47e-01
Processing and activation of SUMO	10	8.46e-02	0.315000	2.47e-01
Regulation of expression of SLITs and ROBOs	154	1.85e-11	-0.314000	6.67e-10
Diseases associated with N-glycosylation of proteins	20	1.50e-02	0.314000	7.88e-02
RAC1 GTPase cycle	130	6.82e-10	-0.314000	2.15e-08
Role of LAT2/NTAL/LAB on calcium mobilization	14	4.22e-02	-0.314000	1.63e-01
Metabolism of polyamines	54	6.81e-05	0.314000	1.24e-03
Signaling by cytosolic FGFR1 fusion mutants	17	2.60e-02	-0.312000	1.14e-01
Ephrin signaling	13	5.20e-02	-0.311000	1.86e-01
Bacterial Infection Pathways	52	1.12e-04	-0.310000	1.81e-03
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	11	7.58e-02	-0.309000	2.29e-01
Caspase activation via Death Receptors in the presence of ligand	14	4.52e-02	0.309000	1.69e-01
Activated NOTCH1 Transmits Signal to the Nucleus	22	1.26e-02	-0.307000	6.89e-02
TICAM1-dependent activation of IRF3/IRF7	11	7.80e-02	-0.307000	2.34e-01
Apoptotic execution phase	32	2.79e-03	-0.306000	2.44e-02
FGFR1 mutant receptor activation	20	1.82e-02	-0.305000	9.11e-02
KSRP (KHSRP) binds and destabilizes mRNA	16	3.54e-02	0.304000	1.43e-01
Regulation of KIT signaling	12	7.00e-02	-0.302000	2.21e-01
Sensory processing of sound by inner hair cells of the cochlea	27	6.90e-03	-0.301000	4.75e-02
Regulation of BACH1 activity	11	8.46e-02	-0.300000	2.47e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	3.29e-02	0.299000	1.35e-01
Nuclear events stimulated by ALK signaling in cancer	19	2.42e-02	-0.299000	1.08e-01
Aggrephagy	30	4.84e-03	-0.297000	3.58e-02
Interleukin receptor SHC signaling	18	2.95e-02	-0.296000	1.24e-01
EPHA-mediated growth cone collapse	10	1.05e-01	-0.296000	2.80e-01
p75NTR recruits signalling complexes	11	9.01e-02	-0.295000	2.60e-01
Sensory processing of sound by outer hair cells of the cochlea	22	1.67e-02	-0.295000	8.66e-02
LDL clearance	15	4.81e-02	-0.295000	1.76e-01
Regulation of ornithine decarboxylase (ODC)	49	4.21e-04	0.291000	5.40e-03
Regulation of innate immune responses to cytosolic DNA	11	9.47e-02	-0.291000	2.66e-01
Glycogen storage diseases	11	9.51e-02	-0.291000	2.66e-01
Receptor Mediated Mitophagy	11	9.52e-02	0.291000	2.66e-01
CDC42 GTPase cycle	107	2.26e-07	-0.290000	6.08e-06
p75 NTR receptor-mediated signalling	71	2.42e-05	-0.290000	5.23e-04
NOTCH4 Intracellular Domain Regulates Transcription	14	6.19e-02	-0.288000	2.05e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	16	4.83e-02	-0.285000	1.76e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	17	4.25e-02	-0.284000	1.64e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes	16	5.01e-02	-0.283000	1.80e-01
EPHB-mediated forward signaling	33	4.97e-03	-0.283000	3.66e-02
RHOH GTPase cycle	26	1.27e-02	-0.282000	6.89e-02
Signaling by EGFR in Cancer	17	4.40e-02	-0.282000	1.66e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	47	8.32e-04	-0.282000	9.71e-03
RUNX3 regulates NOTCH signaling	13	7.95e-02	-0.281000	2.38e-01
Sema3A PAK dependent Axon repulsion	14	6.89e-02	-0.281000	2.20e-01
Transcriptional regulation of granulopoiesis	22	2.27e-02	-0.281000	1.05e-01
DAP12 interactions	28	1.04e-02	-0.280000	5.99e-02
Activation of AMPK downstream of NMDARs	16	5.29e-02	-0.280000	1.87e-01
TP53 Regulates Transcription of Cell Death Genes	36	3.80e-03	0.279000	3.06e-02
Fcgamma receptor (FCGR) dependent phagocytosis	73	4.42e-05	-0.277000	8.76e-04
Prolonged ERK activation events	12	9.88e-02	-0.275000	2.72e-01
EPH-Ephrin signaling	60	2.34e-04	-0.275000	3.29e-03
Major pathway of rRNA processing in the nucleolus and cytosol	172	5.92e-10	-0.275000	1.92e-08
Metabolism of cofactors	16	5.78e-02	0.274000	1.96e-01
VEGFR2 mediated cell proliferation	15	6.94e-02	0.271000	2.21e-01
FCERI mediated Ca+2 mobilization	23	2.50e-02	-0.270000	1.11e-01
Formation of tubulin folding intermediates by CCT/TriC	17	5.44e-02	-0.270000	1.91e-01
Notch-HLH transcription pathway	26	1.77e-02	-0.269000	9.06e-02
Nervous system development	362	3.43e-18	-0.268000	2.22e-16
MHC class II antigen presentation	90	1.24e-05	-0.267000	2.72e-04
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	33	8.09e-03	-0.267000	5.28e-02
Axon guidance	350	1.95e-17	-0.266000	1.20e-15
Regulation of NF-kappa B signaling	18	5.34e-02	-0.263000	1.88e-01
rRNA processing	203	1.50e-10	-0.262000	5.12e-09
Formation of the cornified envelope	14	9.06e-02	0.261000	2.60e-01
Keratinization	14	9.06e-02	0.261000	2.60e-01
Nef mediated downregulation of MHC class I complex cell surface expression	10	1.54e-01	-0.260000	3.54e-01
HDACs deacetylate histones	32	1.10e-02	-0.260000	6.25e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	33	9.91e-03	-0.260000	5.86e-02
SARS-CoV-1 activates/modulates innate immune responses	36	7.18e-03	-0.259000	4.84e-02
Maternal to zygotic transition (MZT)	50	1.58e-03	-0.258000	1.64e-02
Inactivation of APC/C via direct inhibition of the APC/C complex	16	7.40e-02	0.258000	2.28e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	16	7.40e-02	0.258000	2.28e-01
Uptake and actions of bacterial toxins	16	7.45e-02	-0.258000	2.29e-01
VLDLR internalisation and degradation	14	9.61e-02	-0.257000	2.67e-01
Growth hormone receptor signaling	14	9.83e-02	-0.255000	2.72e-01
Integration of provirus	14	9.99e-02	0.254000	2.73e-01
SARS-CoV-1 Infection	131	5.83e-07	-0.253000	1.48e-05
Nuclear signaling by ERBB4	18	6.36e-02	-0.253000	2.08e-01
Inactivation, recovery and regulation of the phototransduction cascade	16	8.04e-02	0.253000	2.39e-01
Plasma lipoprotein clearance	28	2.08e-02	-0.252000	9.92e-02
Nuclear Events (kinase and transcription factor activation)	44	3.81e-03	-0.252000	3.06e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	7.49e-02	0.250000	2.29e-01
Basigin interactions	17	7.55e-02	-0.249000	2.29e-01
Potential therapeutics for SARS	82	1.07e-04	-0.248000	1.75e-03
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	13	1.23e-01	0.247000	3.11e-01
rRNA processing in the nucleus and cytosol	182	1.04e-08	-0.247000	3.06e-07
Diseases associated with glycosylation precursor biosynthesis	15	9.93e-02	0.246000	2.72e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	59	1.11e-03	-0.246000	1.22e-02
Leading Strand Synthesis	13	1.25e-01	0.246000	3.14e-01
Polymerase switching	13	1.25e-01	0.246000	3.14e-01
Mitochondrial translation	94	4.16e-05	0.245000	8.55e-04
RET signaling	23	4.27e-02	-0.244000	1.64e-01
Signaling by ERBB2	35	1.27e-02	-0.244000	6.89e-02
Somitogenesis	46	4.37e-03	0.243000	3.35e-02
Mitochondrial translation termination	88	9.19e-05	0.242000	1.59e-03
Metabolism of steroid hormones	16	9.58e-02	0.241000	2.67e-01
The NLRP3 inflammasome	15	1.09e-01	-0.239000	2.89e-01
Collagen degradation	19	7.22e-02	-0.238000	2.25e-01
FCGR3A-mediated IL10 synthesis	26	3.56e-02	-0.238000	1.43e-01
APC/C:Cdc20 mediated degradation of Securin	63	1.09e-03	0.238000	1.21e-02
Signaling by ALK	21	5.93e-02	-0.238000	1.99e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	41	8.46e-03	-0.238000	5.29e-02
CaM pathway	23	4.87e-02	-0.238000	1.76e-01
Calmodulin induced events	23	4.87e-02	-0.238000	1.76e-01
Translesion synthesis by POLI	16	1.00e-01	-0.237000	2.73e-01
Amino acid transport across the plasma membrane	18	8.14e-02	-0.237000	2.41e-01
Role of phospholipids in phagocytosis	17	9.27e-02	-0.236000	2.64e-01
PI3K Cascade	18	8.36e-02	-0.236000	2.47e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	14	1.27e-01	0.236000	3.14e-01
RHO GTPase cycle	321	5.67e-13	-0.236000	2.45e-11
L1CAM interactions	59	1.78e-03	-0.236000	1.74e-02
Constitutive Signaling by EGFRvIII	12	1.58e-01	-0.235000	3.58e-01
Signaling by EGFRvIII in Cancer	12	1.58e-01	-0.235000	3.58e-01
Erythropoietin activates RAS	13	1.44e-01	-0.234000	3.39e-01
The role of Nef in HIV-1 replication and disease pathogenesis	24	4.77e-02	-0.234000	1.75e-01
MyD88 deficiency (TLR2/4)	14	1.30e-01	-0.234000	3.17e-01
Circadian Clock	58	2.13e-03	-0.233000	2.01e-02
RHOU GTPase cycle	34	1.87e-02	-0.233000	9.14e-02
Interleukin-20 family signaling	13	1.46e-01	-0.233000	3.43e-01
Frs2-mediated activation	10	2.03e-01	-0.233000	4.25e-01
Regulation of TP53 Activity through Methylation	18	8.79e-02	-0.232000	2.55e-01
Signaling by FGFR1 in disease	26	4.03e-02	-0.232000	1.58e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	12	1.64e-01	-0.232000	3.69e-01
Regulation of NPAS4 gene expression	11	1.83e-01	-0.232000	3.98e-01
RHOF GTPase cycle	30	2.81e-02	-0.232000	1.20e-01
Autodegradation of Cdh1 by Cdh1:APC/C	62	1.66e-03	0.231000	1.67e-02
Mitochondrial translation initiation	88	1.89e-04	0.231000	2.72e-03
Translesion synthesis by POLK	16	1.11e-01	-0.230000	2.92e-01
Pre-NOTCH Transcription and Translation	30	2.93e-02	-0.230000	1.24e-01
TP53 Regulates Transcription of Cell Cycle Genes	35	1.86e-02	-0.230000	9.14e-02
Developmental Biology	581	8.82e-21	-0.230000	6.01e-19
The phototransduction cascade	17	1.01e-01	0.230000	2.73e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	67	1.19e-03	0.229000	1.30e-02
Cross-presentation of soluble exogenous antigens (endosomes)	46	7.19e-03	0.229000	4.84e-02
Signaling by Non-Receptor Tyrosine Kinases	36	1.80e-02	-0.228000	9.08e-02
Signaling by PTK6	36	1.80e-02	-0.228000	9.08e-02
Mitochondrial translation elongation	88	2.25e-04	0.228000	3.20e-03
Deactivation of the beta-catenin transactivating complex	29	3.43e-02	-0.227000	1.40e-01
Defective CFTR causes cystic fibrosis	57	3.04e-03	0.227000	2.61e-02
Formation of apoptosome	10	2.14e-01	0.227000	4.38e-01
Regulation of the apoptosome activity	10	2.14e-01	0.227000	4.38e-01
Asymmetric localization of PCP proteins	51	5.10e-03	0.227000	3.73e-02
Mitochondrial protein import	63	1.95e-03	0.226000	1.87e-02
Integrin cell surface interactions	31	2.96e-02	-0.226000	1.24e-01
Peroxisomal lipid metabolism	24	5.63e-02	0.225000	1.94e-01
FLT3 Signaling	32	2.83e-02	-0.224000	1.20e-01
Downstream signal transduction	24	5.81e-02	-0.224000	1.96e-01
Signaling by BRAF and RAF1 fusions	52	5.34e-03	-0.224000	3.86e-02
Inactivation of CSF3 (G-CSF) signaling	23	6.37e-02	-0.223000	2.08e-01
RAF-independent MAPK1/3 activation	18	1.01e-01	-0.223000	2.73e-01
Signal regulatory protein family interactions	11	2.01e-01	-0.223000	4.24e-01
Peptide ligand-binding receptors	29	3.83e-02	0.222000	1.52e-01
Signaling by ERBB4	33	2.79e-02	-0.221000	1.20e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	24	6.08e-02	-0.221000	2.03e-01
Retinoid metabolism and transport	18	1.05e-01	-0.221000	2.80e-01
B-WICH complex positively regulates rRNA expression	25	5.65e-02	-0.221000	1.94e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	48	8.39e-03	-0.220000	5.28e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	48	8.39e-03	-0.220000	5.28e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	48	8.39e-03	-0.220000	5.28e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	48	8.39e-03	-0.220000	5.28e-02
Signaling by NOTCH1 in Cancer	48	8.39e-03	-0.220000	5.28e-02
HS-GAG degradation	13	1.70e-01	-0.220000	3.79e-01
Diseases associated with the TLR signaling cascade	26	5.27e-02	-0.220000	1.87e-01
Diseases of Immune System	26	5.27e-02	-0.220000	1.87e-01
Endogenous sterols	13	1.71e-01	-0.220000	3.79e-01
p38MAPK events	11	2.10e-01	0.218000	4.35e-01
Budding and maturation of HIV virion	34	2.80e-02	0.218000	1.20e-01
BBSome-mediated cargo-targeting to cilium	17	1.22e-01	0.217000	3.10e-01
Glycogen breakdown (glycogenolysis)	12	1.94e-01	0.217000	4.15e-01
Phosphorylation of the APC/C	16	1.34e-01	0.217000	3.23e-01
Retrograde transport at the Trans-Golgi-Network	48	9.62e-03	0.216000	5.76e-02
N-Glycan antennae elongation	10	2.37e-01	0.216000	4.65e-01
Interconversion of nucleotide di- and triphosphates	24	6.80e-02	0.215000	2.19e-01
Transcription of the HIV genome	65	2.81e-03	0.215000	2.44e-02
Methylation	10	2.42e-01	0.214000	4.69e-01
Pentose phosphate pathway	12	2.00e-01	-0.214000	4.24e-01
Interleukin-4 and Interleukin-13 signaling	61	4.04e-03	-0.213000	3.15e-02
Assembly and cell surface presentation of NMDA receptors	20	9.92e-02	-0.213000	2.72e-01
Hedgehog ligand biogenesis	56	5.93e-03	0.213000	4.15e-02
Ubiquitin-dependent degradation of Cyclin D	50	9.32e-03	0.213000	5.66e-02
Vif-mediated degradation of APOBEC3G	53	7.82e-03	0.211000	5.17e-02
Degradation of the extracellular matrix	45	1.45e-02	-0.211000	7.62e-02
Sulfur amino acid metabolism	19	1.13e-01	0.210000	2.95e-01
Negative regulation of FGFR1 signaling	19	1.13e-01	-0.210000	2.95e-01
NR1H2 and NR1H3-mediated signaling	37	2.73e-02	-0.210000	1.18e-01
HIV Transcription Initiation	42	1.88e-02	0.210000	9.14e-02
RNA Polymerase II HIV Promoter Escape	42	1.88e-02	0.210000	9.14e-02
RNA Polymerase II Promoter Escape	42	1.88e-02	0.210000	9.14e-02
RNA Polymerase II Transcription Initiation	42	1.88e-02	0.210000	9.14e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	42	1.88e-02	0.210000	9.14e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	42	1.88e-02	0.210000	9.14e-02
Signaling by NOTCH1	58	5.85e-03	-0.210000	4.13e-02
RAC2 GTPase cycle	69	2.68e-03	-0.209000	2.36e-02
Signaling by TGF-beta Receptor Complex	74	1.93e-03	-0.209000	1.87e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	1.25e-01	0.209000	3.14e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	64	3.92e-03	0.209000	3.10e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	64	3.92e-03	0.209000	3.10e-02
SCF(Skp2)-mediated degradation of p27/p21	55	7.66e-03	0.208000	5.09e-02
APC/C:Cdc20 mediated degradation of mitotic proteins	66	3.74e-03	0.207000	3.06e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	66	3.74e-03	0.207000	3.06e-02
STAT3 nuclear events downstream of ALK signaling	10	2.60e-01	-0.206000	4.87e-01
Hh mutants abrogate ligand secretion	54	9.20e-03	0.205000	5.62e-02
Nucleotide biosynthesis	11	2.40e-01	0.205000	4.67e-01
FLT3 signaling in disease	25	7.65e-02	-0.205000	2.30e-01
CDK-mediated phosphorylation and removal of Cdc6	64	4.70e-03	0.205000	3.52e-02
Translesion synthesis by REV1	15	1.70e-01	-0.205000	3.79e-01
Signaling by CSF3 (G-CSF)	28	6.12e-02	-0.205000	2.03e-01
Positive epigenetic regulation of rRNA expression	40	2.54e-02	-0.204000	1.12e-01
RUNX3 regulates p14-ARF	10	2.63e-01	-0.204000	4.92e-01
Keratan sulfate biosynthesis	13	2.03e-01	0.204000	4.25e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	52	1.11e-02	0.204000	6.25e-02
Polymerase switching on the C-strand of the telomere	22	9.89e-02	0.203000	2.72e-01
Ca-dependent events	25	7.89e-02	-0.203000	2.36e-01
Hh mutants are degraded by ERAD	53	1.09e-02	0.202000	6.25e-02
RNA Polymerase III Transcription Termination	20	1.18e-01	0.202000	3.01e-01
Post NMDA receptor activation events	46	1.81e-02	-0.202000	9.08e-02
RHO GTPases activate CIT	12	2.27e-01	-0.201000	4.56e-01
Formation of Fibrin Clot (Clotting Cascade)	10	2.71e-01	-0.201000	5.00e-01
Josephin domain DUBs	10	2.73e-01	-0.200000	5.00e-01
Signaling by high-kinase activity BRAF mutants	27	7.17e-02	-0.200000	2.25e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	1.68e-01	-0.199000	3.76e-01
Signaling by TGFB family members	84	1.68e-03	-0.199000	1.67e-02
Signaling by BMP	15	1.83e-01	-0.199000	3.99e-01
Pre-NOTCH Expression and Processing	45	2.14e-02	-0.198000	1.01e-01
SARS-CoV-2-host interactions	169	9.22e-06	-0.198000	2.09e-04
RNA Polymerase III Transcription Initiation From Type 1 Promoter	27	7.47e-02	0.198000	2.29e-01
Interferon gamma signaling	71	3.93e-03	-0.198000	3.10e-02
Signaling by NTRKs	96	8.20e-04	-0.198000	9.65e-03
EGFR downregulation	20	1.25e-01	-0.198000	3.14e-01
G-protein beta:gamma signalling	23	1.00e-01	-0.198000	2.73e-01
RAC3 GTPase cycle	69	4.55e-03	-0.198000	3.44e-02
Signaling by NTRK1 (TRKA)	84	1.77e-03	-0.198000	1.74e-02
RHO GTPases Activate ROCKs	16	1.71e-01	-0.198000	3.79e-01
Translation	265	3.79e-08	-0.197000	1.07e-06
IGF1R signaling cascade	24	9.45e-02	-0.197000	2.66e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	24	9.45e-02	-0.197000	2.66e-01
G-protein mediated events	35	4.37e-02	-0.197000	1.66e-01
APC truncation mutants have impaired AXIN binding	12	2.37e-01	0.197000	4.65e-01
AXIN missense mutants destabilize the destruction complex	12	2.37e-01	0.197000	4.65e-01
Signaling by AMER1 mutants	12	2.37e-01	0.197000	4.65e-01
Signaling by APC mutants	12	2.37e-01	0.197000	4.65e-01
Signaling by AXIN mutants	12	2.37e-01	0.197000	4.65e-01
Truncations of AMER1 destabilize the destruction complex	12	2.37e-01	0.197000	4.65e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	18	1.49e-01	-0.197000	3.46e-01
Regulation of RUNX3 expression and activity	55	1.19e-02	0.196000	6.57e-02
Leishmania infection	119	2.39e-04	-0.196000	3.29e-03
Parasitic Infection Pathways	119	2.39e-04	-0.196000	3.29e-03
Prefoldin mediated transfer of substrate to CCT/TriC	23	1.05e-01	-0.195000	2.80e-01
NOTCH1 Intracellular Domain Regulates Transcription	41	3.08e-02	-0.195000	1.28e-01
ABC transporter disorders	62	8.24e-03	0.194000	5.28e-02
Signaling by SCF-KIT	34	5.01e-02	-0.194000	1.80e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	64	7.41e-03	0.194000	4.94e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	2.04e-02	0.194000	9.77e-02
Assembly of the pre-replicative complex	75	3.81e-03	0.194000	3.06e-02
TICAM1, RIP1-mediated IKK complex recruitment	18	1.55e-01	-0.194000	3.55e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	16	1.80e-01	0.193000	3.94e-01
HSF1 activation	23	1.11e-01	-0.192000	2.92e-01
mRNA 3’-end processing	55	1.42e-02	-0.191000	7.50e-02
Signaling by Rho GTPases	460	3.58e-12	-0.191000	1.41e-10
Attenuation phase	19	1.50e-01	-0.191000	3.47e-01
PKA-mediated phosphorylation of CREB	13	2.35e-01	-0.190000	4.65e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	17	1.75e-01	0.190000	3.85e-01
ABC-family proteins mediated transport	77	3.99e-03	0.190000	3.13e-02
Signaling by PDGF	34	5.58e-02	-0.190000	1.94e-01
IRS-related events triggered by IGF1R	23	1.16e-01	-0.190000	3.00e-01
Constitutive Signaling by Overexpressed ERBB2	10	3.00e-01	-0.189000	5.23e-01
DNA Replication Pre-Initiation	85	2.68e-03	0.189000	2.36e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	49	2.28e-02	0.188000	1.05e-01
p53-Independent DNA Damage Response	49	2.28e-02	0.188000	1.05e-01
p53-Independent G1/S DNA damage checkpoint	49	2.28e-02	0.188000	1.05e-01
SCF-beta-TrCP mediated degradation of Emi1	51	2.03e-02	0.188000	9.76e-02
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	473	4.37e-12	-0.188000	1.67e-10
Vpu mediated degradation of CD4	51	2.05e-02	0.188000	9.78e-02
Autodegradation of the E3 ubiquitin ligase COP1	49	2.34e-02	0.187000	1.06e-01
Oncogenic MAPK signaling	66	8.75e-03	-0.187000	5.37e-02
Platelet degranulation	73	5.86e-03	-0.187000	4.13e-02
Regulation of Apoptosis	51	2.13e-02	0.187000	1.01e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	2.11e-01	-0.187000	4.35e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	2.11e-01	-0.187000	4.35e-01
Carboxyterminal post-translational modifications of tubulin	21	1.41e-01	-0.186000	3.35e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	15	2.16e-01	-0.185000	4.41e-01
Neutrophil degranulation	376	1.17e-09	-0.184000	3.60e-08
FCERI mediated MAPK activation	26	1.05e-01	-0.184000	2.80e-01
Other interleukin signaling	16	2.04e-01	-0.184000	4.26e-01
Degradation of cysteine and homocysteine	10	3.16e-01	0.183000	5.35e-01
Signaling by ERBB2 ECD mutants	12	2.73e-01	-0.183000	5.00e-01
Negative regulation of NOTCH4 signaling	53	2.18e-02	0.182000	1.02e-01
PKA activation in glucagon signalling	10	3.20e-01	-0.182000	5.39e-01
SARS-CoV Infections	344	1.07e-08	-0.181000	3.08e-07
RORA activates gene expression	17	1.97e-01	-0.181000	4.20e-01
Regulation of TP53 Expression and Degradation	34	6.88e-02	-0.180000	2.20e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	18	1.85e-01	0.180000	4.02e-01
Degradation of DVL	53	2.40e-02	0.179000	1.08e-01
Sphingolipid de novo biosynthesis	25	1.21e-01	0.179000	3.07e-01
RNA Polymerase III Chain Elongation	17	2.01e-01	0.179000	4.24e-01
Regulation of APC/C activators between G1/S and early anaphase	69	1.05e-02	0.178000	6.07e-02
Death Receptor Signaling	121	7.29e-04	-0.178000	8.74e-03
Glutamate binding, activation of AMPA receptors and synaptic plasticity	16	2.18e-01	0.178000	4.42e-01
Trafficking of AMPA receptors	16	2.18e-01	0.178000	4.42e-01
Platelet Aggregation (Plug Formation)	22	1.49e-01	-0.178000	3.46e-01
Regulation of IFNG signaling	12	2.87e-01	-0.178000	5.10e-01
APC/C-mediated degradation of cell cycle proteins	74	8.69e-03	0.177000	5.36e-02
Regulation of mitotic cell cycle	74	8.69e-03	0.177000	5.36e-02
FOXO-mediated transcription of cell death genes	14	2.55e-01	-0.176000	4.85e-01
Downstream signaling of activated FGFR1	13	2.73e-01	-0.176000	5.00e-01
SUMOylation of immune response proteins	11	3.14e-01	-0.176000	5.32e-01
Pre-NOTCH Processing in Golgi	16	2.24e-01	-0.175000	4.52e-01
Pyroptosis	23	1.46e-01	0.175000	3.44e-01
Telomere C-strand synthesis initiation	13	2.75e-01	0.175000	5.03e-01
Cell surface interactions at the vascular wall	76	8.59e-03	-0.175000	5.35e-02
Synthesis of PIPs at the plasma membrane	44	4.53e-02	-0.175000	1.69e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	60	1.96e-02	0.174000	9.47e-02
IRAK4 deficiency (TLR2/4)	15	2.42e-01	-0.174000	4.69e-01
Downregulation of TGF-beta receptor signaling	24	1.40e-01	-0.174000	3.33e-01
Response to elevated platelet cytosolic Ca2+	77	8.34e-03	-0.174000	5.28e-02
Transcriptional Regulation by NPAS4	23	1.48e-01	-0.174000	3.46e-01
Netrin-1 signaling	21	1.68e-01	0.174000	3.76e-01
Regulated proteolysis of p75NTR	10	3.44e-01	-0.173000	5.65e-01
NIK–>noncanonical NF-kB signaling	57	2.44e-02	0.173000	1.09e-01
RHOA GTPase cycle	100	3.04e-03	-0.172000	2.61e-02
Chondroitin sulfate biosynthesis	10	3.49e-01	-0.171000	5.70e-01
Adherens junctions interactions	24	1.47e-01	-0.171000	3.44e-01
Synthesis of PA	22	1.65e-01	0.171000	3.71e-01
Dectin-1 mediated noncanonical NF-kB signaling	59	2.32e-02	0.171000	1.06e-01
Switching of origins to a post-replicative state	77	9.64e-03	0.171000	5.76e-02
Cyclin A/B1/B2 associated events during G2/M transition	15	2.53e-01	0.171000	4.84e-01
RNA Polymerase III Abortive And Retractive Initiation	37	7.35e-02	0.170000	2.28e-01
RNA Polymerase III Transcription	37	7.35e-02	0.170000	2.28e-01
PLC beta mediated events	33	9.14e-02	-0.170000	2.61e-01
Plasma lipoprotein assembly, remodeling, and clearance	46	4.64e-02	-0.170000	1.72e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	26	1.34e-01	0.170000	3.24e-01
Diseases of glycosylation	67	1.69e-02	0.169000	8.73e-02
Intra-Golgi traffic	39	6.85e-02	0.169000	2.20e-01
Nephrin family interactions	15	2.59e-01	-0.168000	4.87e-01
Recognition of DNA damage by PCNA-containing replication complex	26	1.39e-01	-0.168000	3.32e-01
Regulation of TP53 Degradation	33	9.66e-02	-0.167000	2.68e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	43	5.81e-02	0.167000	1.96e-01
HIV Transcription Elongation	43	5.81e-02	0.167000	1.96e-01
Tat-mediated elongation of the HIV-1 transcript	43	5.81e-02	0.167000	1.96e-01
ATF4 activates genes in response to endoplasmic reticulum stress	24	1.57e-01	0.167000	3.58e-01
COPI-independent Golgi-to-ER retrograde traffic	40	6.84e-02	-0.167000	2.20e-01
Interleukin-37 signaling	15	2.64e-01	-0.167000	4.93e-01
Signaling by Receptor Tyrosine Kinases	329	2.65e-07	-0.166000	6.99e-06
Cytochrome c-mediated apoptotic response	12	3.22e-01	0.165000	5.39e-01
PINK1-PRKN Mediated Mitophagy	21	1.90e-01	-0.165000	4.09e-01
Metabolism of water-soluble vitamins and cofactors	86	8.33e-03	0.165000	5.28e-02
Regulation of RAS by GAPs	62	2.52e-02	0.165000	1.12e-01
RHOV GTPase cycle	28	1.32e-01	-0.165000	3.21e-01
E3 ubiquitin ligases ubiquitinate target proteins	40	7.22e-02	-0.164000	2.25e-01
Azathioprine ADME	16	2.55e-01	0.164000	4.85e-01
Metalloprotease DUBs	16	2.56e-01	-0.164000	4.85e-01
PERK regulates gene expression	29	1.28e-01	0.163000	3.14e-01
Ras activation upon Ca2+ influx through NMDA receptor	10	3.71e-01	0.163000	5.90e-01
Anti-inflammatory response favouring Leishmania parasite infection	46	5.61e-02	-0.163000	1.94e-01
Leishmania parasite growth and survival	46	5.61e-02	-0.163000	1.94e-01
GPCR downstream signalling	202	7.13e-05	-0.163000	1.28e-03
STING mediated induction of host immune responses	12	3.29e-01	-0.163000	5.47e-01
Activation of NMDA receptors and postsynaptic events	53	4.11e-02	-0.162000	1.60e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	52	4.36e-02	0.162000	1.66e-01
Platelet activation, signaling and aggregation	163	3.79e-04	-0.162000	4.96e-03
DARPP-32 events	21	1.99e-01	-0.162000	4.22e-01
Myogenesis	14	2.95e-01	-0.162000	5.16e-01
Metabolic disorders of biological oxidation enzymes	15	2.78e-01	0.162000	5.07e-01
Condensation of Prophase Chromosomes	11	3.54e-01	-0.161000	5.77e-01
Degradation of AXIN	52	4.46e-02	0.161000	1.67e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	16	2.65e-01	-0.161000	4.93e-01
Neurodegenerative Diseases	16	2.65e-01	-0.161000	4.93e-01
O-linked glycosylation	37	9.09e-02	0.161000	2.60e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	3.00e-01	0.160000	5.23e-01
Initiation of Nuclear Envelope (NE) Reformation	16	2.69e-01	-0.160000	4.99e-01
Detoxification of Reactive Oxygen Species	27	1.52e-01	-0.159000	3.49e-01
DNA Replication	102	5.54e-03	0.159000	3.98e-02
Chromatin modifying enzymes	188	1.78e-04	-0.159000	2.61e-03
Chromatin organization	188	1.78e-04	-0.159000	2.61e-03
Regulation of Expression and Function of Type II Classical Cadherins	15	2.86e-01	-0.159000	5.10e-01
Regulation of Homotypic Cell-Cell Adhesion	15	2.86e-01	-0.159000	5.10e-01
Early Phase of HIV Life Cycle	21	2.07e-01	0.159000	4.31e-01
Glycosphingolipid catabolism	24	1.78e-01	-0.159000	3.91e-01
Amino acids regulate mTORC1	45	6.53e-02	0.159000	2.12e-01
PKA activation	11	3.62e-01	-0.159000	5.85e-01
Synthesis of DNA	97	7.05e-03	0.159000	4.83e-02
Beta-oxidation of very long chain fatty acids	10	3.86e-01	0.158000	5.99e-01
Synthesis of PIPs at the early endosome membrane	15	2.89e-01	-0.158000	5.12e-01
Zinc transporters	11	3.65e-01	0.158000	5.86e-01
Selective autophagy	65	2.82e-02	-0.158000	1.20e-01
Negative regulators of DDX58/IFIH1 signaling	34	1.12e-01	-0.158000	2.95e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	3.89e-01	-0.158000	6.01e-01
Regulation of CDH11 Expression and Function	14	3.08e-01	-0.157000	5.30e-01
G alpha (s) signalling events	46	6.55e-02	-0.157000	2.12e-01
MAP2K and MAPK activation	30	1.38e-01	-0.157000	3.30e-01
RHO GTPase Effectors	193	1.89e-04	-0.157000	2.72e-03
IRS-mediated signalling	22	2.04e-01	-0.156000	4.26e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	61	3.49e-02	0.156000	1.42e-01
TRAF3-dependent IRF activation pathway	13	3.30e-01	-0.156000	5.47e-01
Cell-Cell communication	73	2.15e-02	-0.156000	1.01e-01
RNA Polymerase III Transcription Initiation	34	1.16e-01	0.156000	3.00e-01
Glucagon-type ligand receptors	10	3.94e-01	0.156000	6.07e-01
Prostacyclin signalling through prostacyclin receptor	10	3.94e-01	0.156000	6.07e-01
Infectious disease	748	1.12e-12	-0.156000	4.67e-11
BMAL1:CLOCK,NPAS2 activates circadian gene expression	21	2.18e-01	-0.155000	4.42e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	49	6.01e-02	-0.155000	2.01e-01
Meiotic recombination	17	2.71e-01	0.154000	5.00e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	3.77e-01	0.154000	5.91e-01
AKT phosphorylates targets in the cytosol	14	3.20e-01	0.154000	5.39e-01
RAF activation	31	1.40e-01	0.153000	3.33e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	35	1.17e-01	-0.153000	3.00e-01
Signaling by RAS mutants	35	1.17e-01	-0.153000	3.00e-01
Signaling by moderate kinase activity BRAF mutants	35	1.17e-01	-0.153000	3.00e-01
Signaling downstream of RAS mutants	35	1.17e-01	-0.153000	3.00e-01
TGF-beta receptor signaling activates SMADs	35	1.18e-01	-0.153000	3.01e-01
Sensory Perception	74	2.34e-02	-0.153000	1.06e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	14	3.24e-01	-0.152000	5.42e-01
TAK1-dependent IKK and NF-kappa-B activation	39	1.01e-01	-0.152000	2.73e-01
Integrin signaling	21	2.29e-01	-0.152000	4.56e-01
Mitochondrial Fatty Acid Beta-Oxidation	31	1.44e-01	0.152000	3.39e-01
G beta:gamma signalling through PI3Kgamma	17	2.79e-01	-0.152000	5.08e-01
G alpha (i) signalling events	97	1.00e-02	-0.152000	5.90e-02
Synthesis of substrates in N-glycan biosythesis	50	6.41e-02	0.152000	2.08e-01
Stabilization of p53	54	5.45e-02	0.151000	1.91e-01
Signaling by NTRK2 (TRKB)	17	2.81e-01	-0.151000	5.09e-01
Extracellular matrix organization	100	9.41e-03	-0.151000	5.67e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript	69	3.08e-02	-0.151000	1.28e-01
RHOB GTPase cycle	44	8.46e-02	-0.150000	2.47e-01
Late Phase of HIV Life Cycle	135	2.63e-03	0.150000	2.35e-02
Formation of HIV elongation complex in the absence of HIV Tat	44	8.47e-02	0.150000	2.47e-01
Cell junction organization	48	7.20e-02	-0.150000	2.25e-01
Inositol phosphate metabolism	28	1.70e-01	-0.150000	3.79e-01
Vitamin B5 (pantothenate) metabolism	13	3.51e-01	0.149000	5.73e-01
Thrombin signalling through proteinase activated receptors (PARs)	19	2.60e-01	-0.149000	4.87e-01
RHOC GTPase cycle	52	6.29e-02	-0.149000	2.08e-01
Lysosome Vesicle Biogenesis	30	1.57e-01	-0.149000	3.58e-01
Orc1 removal from chromatin	60	4.63e-02	0.149000	1.72e-01
Signaling by RAF1 mutants	31	1.52e-01	-0.149000	3.49e-01
RNA Polymerase II Transcription Termination	62	4.34e-02	-0.149000	1.66e-01
ROS and RNS production in phagocytes	25	1.99e-01	-0.148000	4.22e-01
Signaling by MET	50	6.99e-02	-0.148000	2.21e-01
GPER1 signaling	26	1.92e-01	-0.148000	4.11e-01
Negative regulation of FGFR2 signaling	17	2.92e-01	-0.148000	5.13e-01
Negative regulation of FGFR3 signaling	17	2.92e-01	-0.148000	5.13e-01
Negative regulation of FGFR4 signaling	17	2.92e-01	-0.148000	5.13e-01
tRNA processing in the nucleus	56	5.66e-02	0.147000	1.94e-01
Negative regulation of MAPK pathway	36	1.26e-01	-0.147000	3.14e-01
Activation of G protein gated Potassium channels	10	4.20e-01	0.147000	6.33e-01
G protein gated Potassium channels	10	4.20e-01	0.147000	6.33e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	10	4.20e-01	0.147000	6.33e-01
PRC2 methylates histones and DNA	13	3.61e-01	-0.146000	5.84e-01
mRNA Capping	29	1.74e-01	0.146000	3.84e-01
HSF1-dependent transactivation	26	1.98e-01	-0.146000	4.21e-01
Innate Immune System	739	3.17e-11	-0.146000	1.11e-09
activated TAK1 mediates p38 MAPK activation	20	2.60e-01	-0.146000	4.87e-01
SUMOylation of DNA methylation proteins	13	3.64e-01	0.146000	5.86e-01
Signaling by PDGFR in disease	19	2.72e-01	-0.146000	5.00e-01
Removal of the Flap Intermediate	13	3.64e-01	0.145000	5.86e-01
CRMPs in Sema3A signaling	11	4.05e-01	-0.145000	6.18e-01
PCP/CE pathway	70	3.64e-02	0.145000	1.47e-01
Synthesis of IP3 and IP4 in the cytosol	13	3.68e-01	-0.144000	5.87e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	1.95e-01	0.144000	4.16e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	1.95e-01	0.144000	4.16e-01
Cellular response to hypoxia	67	4.17e-02	0.144000	1.62e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	25	2.13e-01	-0.144000	4.38e-01
PKMTs methylate histone lysines	36	1.40e-01	-0.142000	3.33e-01
Transcriptional regulation of white adipocyte differentiation	67	4.44e-02	-0.142000	1.67e-01
Translation of Structural Proteins 9683701	29	1.87e-01	-0.142000	4.04e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	11	4.16e-01	-0.142000	6.30e-01
Transport of Mature Transcript to Cytoplasm	78	3.16e-02	-0.141000	1.30e-01
Signaling by FGFR in disease	42	1.15e-01	-0.141000	2.99e-01
Opioid Signalling	59	6.32e-02	-0.140000	2.08e-01
Hemostasis	346	9.12e-06	-0.140000	2.09e-04
Viral Infection Pathways	616	5.91e-09	-0.139000	1.78e-07
Regulation of RUNX2 expression and activity	63	5.66e-02	0.139000	1.94e-01
Heme signaling	37	1.44e-01	-0.139000	3.39e-01
Factors involved in megakaryocyte development and platelet production	92	2.20e-02	-0.138000	1.03e-01
Oncogene Induced Senescence	27	2.15e-01	-0.138000	4.40e-01
Membrane binding and targetting of GAG proteins	14	3.74e-01	-0.137000	5.91e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	3.74e-01	-0.137000	5.91e-01
Signaling by FGFR1	31	1.86e-01	-0.137000	4.03e-01
Degradation of GLI2 by the proteasome	56	7.60e-02	0.137000	2.29e-01
GLI3 is processed to GLI3R by the proteasome	56	7.60e-02	0.137000	2.29e-01
IRAK1 recruits IKK complex	14	3.75e-01	-0.137000	5.91e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	3.75e-01	-0.137000	5.91e-01
Cohesin Loading onto Chromatin	10	4.54e-01	-0.137000	6.67e-01
Mitotic Telophase/Cytokinesis	10	4.54e-01	-0.137000	6.67e-01
Signaling by ERBB2 in Cancer	14	3.77e-01	-0.136000	5.91e-01
Cleavage of the damaged pyrimidine	14	3.78e-01	0.136000	5.91e-01
Depyrimidination	14	3.78e-01	0.136000	5.91e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	14	3.78e-01	0.136000	5.91e-01
Metabolism of vitamins and cofactors	122	9.73e-03	0.136000	5.78e-02
Syndecan interactions	15	3.63e-01	-0.136000	5.85e-01
SARS-CoV-2 Infection	245	2.79e-04	-0.136000	3.76e-03
DAG and IP3 signaling	27	2.23e-01	-0.136000	4.51e-01
Formation of the Early Elongation Complex	33	1.79e-01	0.135000	3.91e-01
Formation of the HIV-1 Early Elongation Complex	33	1.79e-01	0.135000	3.91e-01
G1/S Transition	103	1.79e-02	0.135000	9.08e-02
Binding and Uptake of Ligands by Scavenger Receptors	20	2.96e-01	-0.135000	5.19e-01
RIP-mediated NFkB activation via ZBP1	15	3.67e-01	-0.135000	5.87e-01
Vpr-mediated nuclear import of PICs	38	1.51e-01	0.135000	3.49e-01
Regulation of RUNX1 Expression and Activity	17	3.37e-01	-0.135000	5.56e-01
Defective Intrinsic Pathway for Apoptosis	19	3.12e-01	-0.134000	5.31e-01
Signaling by FGFR	55	8.62e-02	-0.134000	2.51e-01
RNA Polymerase II Pre-transcription Events	74	4.69e-02	0.134000	1.73e-01
Nucleotide salvage	20	3.01e-01	0.134000	5.23e-01
SUMO E3 ligases SUMOylate target proteins	145	5.60e-03	-0.134000	4.00e-02
Regulation of PTEN stability and activity	65	6.34e-02	0.133000	2.08e-01
Cyclin E associated events during G1/S transition	74	4.83e-02	0.133000	1.76e-01
RHO GTPases Activate Formins	98	2.33e-02	-0.133000	1.06e-01
Neurotransmitter release cycle	20	3.04e-01	-0.133000	5.26e-01
FOXO-mediated transcription	45	1.23e-01	-0.133000	3.11e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	58	8.08e-02	-0.133000	2.40e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	20	3.04e-01	-0.133000	5.26e-01
TNFR1-induced NF-kappa-B signaling pathway	31	2.02e-01	-0.133000	4.25e-01
PI Metabolism	67	6.10e-02	-0.133000	2.03e-01
Scavenging by Class A Receptors	10	4.68e-01	-0.133000	6.80e-01
mRNA Splicing - Major Pathway	200	1.31e-03	-0.132000	1.38e-02
Calnexin/calreticulin cycle	25	2.52e-01	-0.132000	4.84e-01
Spry regulation of FGF signaling	16	3.60e-01	-0.132000	5.82e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	26	2.44e-01	0.132000	4.72e-01
Degradation of beta-catenin by the destruction complex	75	4.91e-02	0.132000	1.77e-01
Metabolism of fat-soluble vitamins	21	2.97e-01	-0.132000	5.19e-01
Ovarian tumor domain proteases	33	1.91e-01	-0.132000	4.11e-01
Signaling by EGFR	36	1.74e-01	-0.131000	3.85e-01
Cristae formation	31	2.07e-01	-0.131000	4.31e-01
Metabolism of amino acids and derivatives	264	2.86e-04	-0.131000	3.81e-03
Interferon alpha/beta signaling	55	9.46e-02	-0.130000	2.66e-01
Regulation of TP53 Activity through Acetylation	28	2.33e-01	-0.130000	4.63e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	11	4.56e-01	-0.130000	6.68e-01
Assembly Of The HIV Virion	22	2.93e-01	0.130000	5.13e-01
HCMV Early Events	65	7.15e-02	-0.129000	2.25e-01
SUMOylation of transcription cofactors	40	1.57e-01	-0.129000	3.58e-01
Constitutive Signaling by AKT1 E17K in Cancer	23	2.84e-01	0.129000	5.10e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	12	4.40e-01	-0.129000	6.55e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	12	4.40e-01	-0.129000	6.55e-01
FGFR2 alternative splicing	24	2.75e-01	-0.129000	5.03e-01
tRNA Aminoacylation	20	3.20e-01	0.129000	5.39e-01
p53-Dependent G1 DNA Damage Response	58	9.08e-02	0.129000	2.60e-01
p53-Dependent G1/S DNA damage checkpoint	58	9.08e-02	0.129000	2.60e-01
Nicotinate metabolism	21	3.08e-01	0.128000	5.30e-01
RMTs methylate histone arginines	30	2.24e-01	-0.128000	4.51e-01
CTLA4 inhibitory signaling	16	3.76e-01	0.128000	5.91e-01
Cytoprotection by HMOX1	57	9.55e-02	-0.128000	2.67e-01
Cytosolic sulfonation of small molecules	11	4.64e-01	-0.128000	6.75e-01
Toll-like Receptor Cascades	140	9.35e-03	-0.128000	5.66e-02
Elastic fibre formation	15	3.94e-01	-0.127000	6.07e-01
Glutathione conjugation	19	3.38e-01	0.127000	5.56e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123	1.53e-02	-0.127000	8.01e-02
Activation of NF-kappaB in B cells	64	7.97e-02	0.127000	2.38e-01
E2F mediated regulation of DNA replication	17	3.66e-01	0.127000	5.87e-01
Signaling by FGFR2	49	1.27e-01	-0.126000	3.14e-01
Cyclin A:Cdk2-associated events at S phase entry	76	5.78e-02	0.126000	1.96e-01
Signaling by FLT3 fusion proteins	18	3.56e-01	-0.126000	5.78e-01
Immune System	1357	6.20e-14	-0.126000	3.21e-12
RHOG GTPase cycle	57	1.02e-01	-0.125000	2.74e-01
mRNA Splicing	208	2.01e-03	-0.125000	1.92e-02
Metabolism of nucleotides	77	5.88e-02	0.125000	1.98e-01
Cytosolic sensors of pathogen-associated DNA	56	1.09e-01	-0.124000	2.89e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	13	4.40e-01	-0.124000	6.55e-01
DNA Double Strand Break Response	40	1.78e-01	-0.123000	3.91e-01
Signaling by FGFR3	25	2.87e-01	-0.123000	5.10e-01
Signaling by FGFR4	25	2.87e-01	-0.123000	5.10e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	39	1.85e-01	-0.123000	4.02e-01
Degradation of GLI1 by the proteasome	56	1.13e-01	0.123000	2.95e-01
O-linked glycosylation of mucins	26	2.81e-01	0.122000	5.09e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	1.25e-01	0.122000	3.14e-01
Signaling by GPCR	218	2.15e-03	-0.121000	2.02e-02
Formation of the beta-catenin:TCF transactivating complex	24	3.06e-01	-0.121000	5.28e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	4.69e-01	-0.121000	6.80e-01
NPAS4 regulates expression of target genes	12	4.69e-01	-0.121000	6.80e-01
Cytochrome P450 - arranged by substrate type	18	3.77e-01	-0.120000	5.91e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	22	3.29e-01	-0.120000	5.47e-01
Disease	1212	8.58e-12	-0.120000	3.18e-10
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	30	2.56e-01	-0.120000	4.85e-01
Class I peroxisomal membrane protein import	18	3.80e-01	0.120000	5.92e-01
Paracetamol ADME	10	5.13e-01	0.119000	7.12e-01
TRP channels	11	4.93e-01	0.119000	6.97e-01
Signal Transduction	1429	3.22e-13	-0.119000	1.54e-11
DDX58/IFIH1-mediated induction of interferon-alpha/beta	63	1.03e-01	-0.119000	2.77e-01
HIV Life Cycle	148	1.29e-02	0.119000	6.97e-02
Iron uptake and transport	45	1.69e-01	-0.119000	3.78e-01
G1/S DNA Damage Checkpoints	59	1.17e-01	0.118000	3.01e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	99	4.35e-02	-0.118000	1.66e-01
Transport of bile salts and organic acids, metal ions and amine compounds	35	2.29e-01	-0.118000	4.56e-01
Formation of paraxial mesoderm	55	1.34e-01	0.117000	3.23e-01
Chondroitin sulfate/dermatan sulfate metabolism	28	2.84e-01	-0.117000	5.10e-01
Collagen formation	28	2.85e-01	-0.117000	5.10e-01
SHC1 events in ERBB2 signaling	11	5.03e-01	0.117000	7.03e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	11	5.03e-01	-0.117000	7.03e-01
Class B/2 (Secretin family receptors)	19	3.82e-01	0.116000	5.93e-01
RHOJ GTPase cycle	45	1.80e-01	-0.116000	3.94e-01
Interferon Signaling	207	4.53e-03	-0.115000	3.44e-02
G2/M Checkpoints	105	4.27e-02	0.115000	1.64e-01
Regulation of IFNA/IFNB signaling	11	5.11e-01	-0.115000	7.09e-01
Inflammasomes	19	3.89e-01	-0.114000	6.01e-01
Retrograde neurotrophin signalling	10	5.32e-01	-0.114000	7.27e-01
CTNNB1 S33 mutants aren’t phosphorylated	13	4.77e-01	0.114000	6.80e-01
CTNNB1 S37 mutants aren’t phosphorylated	13	4.77e-01	0.114000	6.80e-01
CTNNB1 S45 mutants aren’t phosphorylated	13	4.77e-01	0.114000	6.80e-01
CTNNB1 T41 mutants aren’t phosphorylated	13	4.77e-01	0.114000	6.80e-01
Signaling by CTNNB1 phospho-site mutants	13	4.77e-01	0.114000	6.80e-01
Signaling by GSK3beta mutants	13	4.77e-01	0.114000	6.80e-01
Late endosomal microautophagy	30	2.81e-01	-0.114000	5.09e-01
COPII-mediated vesicle transport	58	1.35e-01	0.114000	3.24e-01
SUMOylation	151	1.64e-02	-0.114000	8.55e-02
Triglyceride catabolism	13	4.83e-01	-0.112000	6.87e-01
Signaling by VEGF	84	7.57e-02	-0.112000	2.29e-01
TNFR2 non-canonical NF-kB pathway	75	9.38e-02	0.112000	2.66e-01
DNA Damage Bypass	42	2.09e-01	-0.112000	4.34e-01
N-glycan antennae elongation in the medial/trans-Golgi	15	4.52e-01	0.112000	6.67e-01
S Phase	132	2.67e-02	0.112000	1.17e-01
RAB geranylgeranylation	46	1.89e-01	0.112000	4.08e-01
Mitochondrial tRNA aminoacylation	14	4.69e-01	0.112000	6.80e-01
TNF signaling	52	1.64e-01	-0.112000	3.69e-01
Intraflagellar transport	37	2.40e-01	0.112000	4.68e-01
Processing of Capped Intron-Containing Pre-mRNA	274	1.66e-03	-0.111000	1.67e-02
RHO GTPases activate PKNs	25	3.39e-01	-0.110000	5.58e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	28	3.12e-01	-0.110000	5.31e-01
Arachidonic acid metabolism	22	3.71e-01	-0.110000	5.90e-01
Activation of HOX genes during differentiation	45	2.03e-01	-0.110000	4.25e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	45	2.03e-01	-0.110000	4.25e-01
Insulin receptor signalling cascade	27	3.25e-01	-0.109000	5.43e-01
VEGFA-VEGFR2 Pathway	79	9.34e-02	-0.109000	2.66e-01
RIPK1-mediated regulated necrosis	29	3.09e-01	-0.109000	5.30e-01
Regulation of necroptotic cell death	29	3.09e-01	-0.109000	5.30e-01
Ca2+ pathway	36	2.60e-01	-0.109000	4.87e-01
Estrogen-dependent gene expression	78	9.86e-02	-0.108000	2.72e-01
RUNX2 regulates bone development	16	4.54e-01	-0.108000	6.67e-01
Hedgehog ‘on’ state	65	1.32e-01	0.108000	3.21e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	17	4.41e-01	-0.108000	6.55e-01
Impaired BRCA2 binding to PALB2	18	4.30e-01	-0.107000	6.43e-01
Diseases of signal transduction by growth factor receptors and second messengers	321	1.05e-03	-0.107000	1.18e-02
Interleukin-7 signaling	12	5.21e-01	-0.107000	7.16e-01
Epigenetic regulation of gene expression	116	4.71e-02	-0.107000	1.73e-01
Cyclin D associated events in G1	38	2.56e-01	-0.107000	4.85e-01
G1 Phase	38	2.56e-01	-0.107000	4.85e-01
RND2 GTPase cycle	28	3.32e-01	-0.106000	5.49e-01
tRNA modification in the nucleus and cytosol	36	2.73e-01	0.106000	5.00e-01
Protein methylation	14	4.95e-01	-0.105000	6.98e-01
Nonhomologous End-Joining (NHEJ)	31	3.12e-01	-0.105000	5.31e-01
Beta-catenin phosphorylation cascade	14	4.98e-01	0.105000	7.00e-01
IKK complex recruitment mediated by RIP1	22	3.96e-01	-0.105000	6.09e-01
SLC-mediated transmembrane transport	114	5.50e-02	-0.104000	1.92e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE	16	4.70e-01	-0.104000	6.80e-01
Toll Like Receptor 4 (TLR4) Cascade	124	4.55e-02	-0.104000	1.69e-01
Transmission across Chemical Synapses	103	6.92e-02	-0.104000	2.21e-01
G0 and Early G1	15	4.87e-01	-0.104000	6.91e-01
Purine salvage	12	5.36e-01	0.103000	7.30e-01
Signaling by NTRK3 (TRKC)	12	5.37e-01	-0.103000	7.31e-01
EML4 and NUDC in mitotic spindle formation	78	1.17e-01	-0.103000	3.00e-01
Stimuli-sensing channels	42	2.50e-01	-0.103000	4.81e-01
PI3K/AKT Signaling in Cancer	49	2.18e-01	-0.102000	4.42e-01
Pausing and recovery of Tat-mediated HIV elongation	31	3.28e-01	0.102000	5.46e-01
Tat-mediated HIV elongation arrest and recovery	31	3.28e-01	0.102000	5.46e-01
Protein localization	147	3.49e-02	0.101000	1.42e-01
Clathrin-mediated endocytosis	106	7.36e-02	-0.101000	2.28e-01
TRAF6 mediated NF-kB activation	20	4.36e-01	-0.101000	6.50e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	2.24e-01	-0.101000	4.51e-01
Metabolism of RNA	686	1.01e-05	-0.101000	2.26e-04
Platelet sensitization by LDL	14	5.16e-01	0.100000	7.13e-01
Base-Excision Repair, AP Site Formation	16	4.90e-01	0.099700	6.94e-01
Ribavirin ADME	10	5.86e-01	-0.099600	7.67e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	20	4.43e-01	-0.099200	6.56e-01
Downstream signaling events of B Cell Receptor (BCR)	77	1.37e-01	0.098300	3.28e-01
Collagen biosynthesis and modifying enzymes	17	4.87e-01	0.097500	6.91e-01
Heme biosynthesis	12	5.59e-01	0.097400	7.49e-01
Regulation of MECP2 expression and activity	27	3.82e-01	-0.097300	5.93e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	30	3.58e-01	0.097100	5.80e-01
Synthesis of PIPs at the late endosome membrane	10	5.96e-01	-0.096800	7.76e-01
Lagging Strand Synthesis	18	4.77e-01	0.096800	6.80e-01
SUMOylation of intracellular receptors	23	4.23e-01	-0.096500	6.37e-01
Cellular responses to stimuli	634	4.46e-05	-0.096500	8.76e-04
Platelet calcium homeostasis	15	5.18e-01	-0.096300	7.14e-01
HIV Infection	223	1.38e-02	0.096200	7.36e-02
ADORA2B mediated anti-inflammatory cytokines production	24	4.15e-01	-0.096200	6.29e-01
Regulation of TNFR1 signaling	44	2.73e-01	-0.095700	5.00e-01
Cellular responses to stress	626	5.92e-05	-0.095500	1.14e-03
Adaptive Immune System	560	1.44e-04	-0.095300	2.19e-03
Cargo trafficking to the periciliary membrane	38	3.11e-01	0.095200	5.31e-01
Citric acid cycle (TCA cycle)	22	4.41e-01	-0.094900	6.55e-01
Signaling by Nuclear Receptors	173	3.25e-02	-0.094600	1.33e-01
Signaling by Interleukins	307	4.74e-03	-0.094400	3.53e-02
TRAF6 mediated IRF7 activation	15	5.27e-01	-0.094300	7.22e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	29	3.80e-01	0.094200	5.92e-01
Cytokine Signaling in Immune system	531	2.57e-04	-0.093900	3.50e-03
TP53 Regulates Transcription of DNA Repair Genes	60	2.11e-01	0.093600	4.35e-01
Signaling by ERBB2 KD Mutants	13	5.60e-01	-0.093500	7.49e-01
PPARA activates gene expression	95	1.18e-01	-0.092900	3.01e-01
Mitochondrial calcium ion transport	20	4.76e-01	0.092100	6.80e-01
Interactions of Vpr with host cellular proteins	41	3.10e-01	0.091700	5.31e-01
Resolution of Sister Chromatid Cohesion	84	1.48e-01	-0.091600	3.44e-01
Cell-cell junction organization	32	3.71e-01	-0.091400	5.90e-01
SLC transporter disorders	56	2.38e-01	-0.091300	4.66e-01
Neurotransmitter receptors and postsynaptic signal transmission	84	1.50e-01	-0.090900	3.48e-01
Molecules associated with elastic fibres	12	5.86e-01	-0.090900	7.67e-01
G-protein activation	13	5.71e-01	0.090800	7.58e-01
Senescence-Associated Secretory Phenotype (SASP)	44	3.04e-01	-0.089700	5.26e-01
Costimulation by the CD28 family	51	2.69e-01	-0.089600	4.99e-01
UCH proteinases	81	1.66e-01	0.089300	3.73e-01
Resolution of D-Loop Structures	22	4.70e-01	-0.089100	6.80e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	22	4.70e-01	-0.089100	6.80e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	99	1.27e-01	-0.088900	3.14e-01
Toll Like Receptor 2 (TLR2) Cascade	99	1.27e-01	-0.088900	3.14e-01
Toll Like Receptor TLR1:TLR2 Cascade	99	1.27e-01	-0.088900	3.14e-01
Toll Like Receptor TLR6:TLR2 Cascade	99	1.27e-01	-0.088900	3.14e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	84	1.62e-01	0.088500	3.66e-01
Regulation of PLK1 Activity at G2/M Transition	74	1.89e-01	-0.088400	4.08e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	19	5.05e-01	-0.088300	7.03e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	19	5.05e-01	-0.088300	7.03e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	19	5.05e-01	-0.088300	7.03e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	19	5.05e-01	-0.088300	7.03e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	19	5.05e-01	-0.088300	7.03e-01
Signalling to RAS	14	5.69e-01	0.087900	7.57e-01
Regulation of lipid metabolism by PPARalpha	97	1.37e-01	-0.087700	3.28e-01
Apoptotic factor-mediated response	19	5.09e-01	0.087500	7.08e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	161	5.71e-02	0.087200	1.96e-01
Purine catabolism	13	5.88e-01	-0.086800	7.68e-01
Respiratory electron transport	103	1.29e-01	-0.086700	3.16e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	11	6.19e-01	-0.086600	7.94e-01
alpha-linolenic acid (ALA) metabolism	11	6.19e-01	-0.086600	7.94e-01
Neddylation	194	3.87e-02	0.086500	1.53e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	22	4.86e-01	-0.085900	6.90e-01
Activation of the pre-replicative complex	19	5.17e-01	0.085800	7.14e-01
Phase II - Conjugation of compounds	45	3.20e-01	0.085700	5.39e-01
Processive synthesis on the lagging strand	14	5.80e-01	0.085400	7.64e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	49	3.02e-01	-0.085400	5.25e-01
ESR-mediated signaling	125	1.02e-01	-0.085000	2.74e-01
Maturation of nucleoprotein 9694631	15	5.73e-01	-0.084000	7.59e-01
Golgi Cisternae Pericentriolar Stack Reorganization	11	6.32e-01	0.083500	8.04e-01
Defects in vitamin and cofactor metabolism	17	5.52e-01	0.083400	7.43e-01
Negative epigenetic regulation of rRNA expression	42	3.54e-01	-0.082700	5.77e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	17	5.56e-01	-0.082600	7.45e-01
MECP2 regulates neuronal receptors and channels	10	6.52e-01	-0.082400	8.17e-01
Nuclear Pore Complex (NPC) Disassembly	33	4.14e-01	-0.082200	6.28e-01
Synthesis of PC	19	5.36e-01	0.082100	7.30e-01
Mitotic G1 phase and G1/S transition	117	1.28e-01	0.081700	3.14e-01
Formation of RNA Pol II elongation complex	56	2.92e-01	0.081400	5.13e-01
RNA Polymerase II Transcription Elongation	56	2.92e-01	0.081400	5.13e-01
Termination of translesion DNA synthesis	28	4.57e-01	-0.081200	6.69e-01
HDR through MMEJ (alt-NHEJ)	11	6.41e-01	0.081200	8.09e-01
ZBP1(DAI) mediated induction of type I IFNs	18	5.51e-01	-0.081100	7.43e-01
The citric acid (TCA) cycle and respiratory electron transport	169	7.01e-02	-0.081100	2.21e-01
Effects of PIP2 hydrolysis	18	5.53e-01	0.080900	7.43e-01
HIV elongation arrest and recovery	32	4.30e-01	0.080600	6.43e-01
Pausing and recovery of HIV elongation	32	4.30e-01	0.080600	6.43e-01
Interleukin-12 family signaling	42	3.67e-01	-0.080500	5.87e-01
Activation of ATR in response to replication stress	21	5.23e-01	0.080500	7.18e-01
Peptide hormone metabolism	35	4.11e-01	-0.080400	6.26e-01
Telomere C-strand (Lagging Strand) Synthesis	29	4.55e-01	0.080200	6.67e-01
Nuclear Envelope (NE) Reassembly	61	2.80e-01	-0.080100	5.09e-01
Diseases of metabolism	130	1.16e-01	0.080000	3.00e-01
RUNX2 regulates osteoblast differentiation	12	6.36e-01	-0.078800	8.06e-01
Glycogen synthesis	10	6.66e-01	-0.078800	8.24e-01
TBC/RABGAPs	44	3.68e-01	0.078500	5.87e-01
Unfolded Protein Response (UPR)	80	2.29e-01	0.078000	4.56e-01
Signal transduction by L1	15	6.02e-01	-0.077700	7.81e-01
Autophagy	129	1.30e-01	-0.077500	3.17e-01
MAPK6/MAPK4 signaling	77	2.42e-01	0.077300	4.69e-01
Interleukin-10 signaling	24	5.14e-01	-0.077000	7.12e-01
Transcriptional regulation by RUNX2	90	2.12e-01	0.076400	4.36e-01
Protein folding	68	2.78e-01	-0.076200	5.07e-01
Formation of WDR5-containing histone-modifying complexes	40	4.05e-01	-0.076200	6.18e-01
MyD88 cascade initiated on plasma membrane	85	2.28e-01	-0.075900	4.56e-01
Toll Like Receptor 10 (TLR10) Cascade	85	2.28e-01	-0.075900	4.56e-01
Toll Like Receptor 5 (TLR5) Cascade	85	2.28e-01	-0.075900	4.56e-01
PIWI-interacting RNA (piRNA) biogenesis	17	5.89e-01	-0.075800	7.69e-01
Neuronal System	136	1.29e-01	-0.075700	3.15e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	10	6.82e-01	0.074700	8.34e-01
Intrinsic Pathway for Apoptosis	49	3.67e-01	0.074500	5.87e-01
Depolymerization of the Nuclear Lamina	12	6.56e-01	0.074300	8.18e-01
Diseases associated with glycosaminoglycan metabolism	18	5.86e-01	0.074200	7.67e-01
Meiosis	35	4.48e-01	0.074200	6.61e-01
RHOD GTPase cycle	39	4.24e-01	-0.074100	6.37e-01
Mitophagy	28	4.98e-01	-0.074000	7.00e-01
Chaperonin-mediated protein folding	63	3.12e-01	-0.073700	5.31e-01
Metal ion SLC transporters	17	6.00e-01	-0.073600	7.78e-01
Fanconi Anemia Pathway	26	5.18e-01	-0.073300	7.14e-01
Loss of Nlp from mitotic centrosomes	59	3.38e-01	-0.072200	5.56e-01
Loss of proteins required for interphase microtubule organization from the centrosome	59	3.38e-01	-0.072200	5.56e-01
Extra-nuclear estrogen signaling	50	3.79e-01	-0.072100	5.92e-01
FCERI mediated NF-kB activation	74	2.85e-01	0.072000	5.10e-01
Transcriptional Regulation by VENTX	34	4.73e-01	-0.071200	6.80e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	10	6.97e-01	0.071100	8.44e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	25	5.40e-01	0.070800	7.34e-01
Protein ubiquitination	59	3.48e-01	-0.070700	5.70e-01
Toll Like Receptor 3 (TLR3) Cascade	92	2.43e-01	-0.070600	4.69e-01
Activation of GABAB receptors	15	6.40e-01	-0.069800	8.08e-01
GABA B receptor activation	15	6.40e-01	-0.069800	8.08e-01
Gastrulation	66	3.28e-01	0.069700	5.46e-01
Mitochondrial biogenesis	81	2.83e-01	-0.069100	5.10e-01
Signaling by PDGFRA extracellular domain mutants	12	6.79e-01	-0.069000	8.31e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	6.79e-01	-0.069000	8.31e-01
Acyl chain remodelling of PC	10	7.06e-01	0.068900	8.47e-01
Regulation of PTEN mRNA translation	11	6.94e-01	-0.068600	8.42e-01
Regulation of TLR by endogenous ligand	13	6.71e-01	-0.068100	8.26e-01
Drug ADME	39	4.62e-01	0.068100	6.74e-01
Cell Cycle Checkpoints	193	1.06e-01	0.067700	2.82e-01
G2/M Transition	157	1.47e-01	0.067300	3.44e-01
TCR signaling	98	2.51e-01	-0.067300	4.82e-01
Miscellaneous transport and binding events	16	6.43e-01	0.066900	8.10e-01
Signalling to ERKs	27	5.50e-01	-0.066500	7.42e-01
Global Genome Nucleotide Excision Repair (GG-NER)	78	3.11e-01	0.066400	5.31e-01
Translation of Structural Proteins 9694635	54	4.01e-01	-0.066200	6.15e-01
Mitotic G2-G2/M phases	158	1.53e-01	0.066100	3.52e-01
Activation of BH3-only proteins	26	5.62e-01	0.065800	7.51e-01
Caspase activation via extrinsic apoptotic signalling pathway	20	6.11e-01	0.065700	7.88e-01
ADP signalling through P2Y purinoceptor 12	11	7.06e-01	-0.065700	8.47e-01
TP53 Regulates Metabolic Genes	81	3.08e-01	-0.065700	5.30e-01
Antigen processing-Cross presentation	96	2.68e-01	-0.065600	4.99e-01
SARS-CoV-2 modulates autophagy	11	7.07e-01	-0.065400	8.47e-01
PCNA-Dependent Long Patch Base Excision Repair	18	6.36e-01	0.064500	8.06e-01
Pyruvate metabolism	26	5.70e-01	0.064400	7.57e-01
Cargo recognition for clathrin-mediated endocytosis	71	3.58e-01	-0.063300	5.80e-01
ADP signalling through P2Y purinoceptor 1	16	6.62e-01	0.063100	8.20e-01
Translesion Synthesis by POLH	17	6.54e-01	-0.062900	8.17e-01
Fatty acid metabolism	112	2.53e-01	0.062700	4.84e-01
Metabolism of nitric oxide: NOS3 activation and regulation	10	7.31e-01	0.062700	8.60e-01
Cellular response to heat stress	85	3.21e-01	-0.062500	5.39e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	32	5.42e-01	-0.062300	7.35e-01
Asparagine N-linked glycosylation	247	9.45e-02	0.062200	2.66e-01
Cell recruitment (pro-inflammatory response)	22	6.15e-01	-0.062000	7.91e-01
Purinergic signaling in leishmaniasis infection	22	6.15e-01	-0.062000	7.91e-01
Activation of BAD and translocation to mitochondria	14	6.89e-01	0.061700	8.39e-01
Glucagon signaling in metabolic regulation	17	6.61e-01	-0.061400	8.20e-01
Deposition of new CENPA-containing nucleosomes at the centromere	20	6.35e-01	-0.061400	8.06e-01
Nucleosome assembly	20	6.35e-01	-0.061400	8.06e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	10	7.37e-01	-0.061400	8.62e-01
HCMV Infection	88	3.21e-01	-0.061300	5.39e-01
DNA Double-Strand Break Repair	105	2.82e-01	-0.061000	5.09e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	7.04e-01	-0.060900	8.47e-01
GPCR ligand binding	70	3.79e-01	0.060900	5.92e-01
Antigen processing: Ubiquitination & Proteasome degradation	251	1.01e-01	0.060600	2.73e-01
AURKA Activation by TPX2	60	4.19e-01	-0.060400	6.33e-01
Nuclear Receptor transcription pathway	29	5.75e-01	-0.060200	7.60e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	91	3.24e-01	-0.060000	5.42e-01
RAS processing	20	6.43e-01	0.059900	8.10e-01
Protein hydroxylation	15	6.89e-01	-0.059600	8.39e-01
PTEN Regulation	129	2.47e-01	0.059200	4.76e-01
Disorders of transmembrane transporters	118	2.69e-01	0.059100	4.99e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	10	7.47e-01	-0.059000	8.73e-01
APC-Cdc20 mediated degradation of Nek2A	20	6.48e-01	0.059000	8.12e-01
Biotin transport and metabolism	11	7.36e-01	0.058800	8.62e-01
NoRC negatively regulates rRNA expression	40	5.21e-01	-0.058700	7.16e-01
G beta:gamma signalling through PLC beta	11	7.36e-01	-0.058600	8.62e-01
Presynaptic function of Kainate receptors	11	7.36e-01	-0.058600	8.62e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	62	4.27e-01	0.058400	6.41e-01
Non-integrin membrane-ECM interactions	21	6.45e-01	0.058200	8.10e-01
Smooth Muscle Contraction	23	6.30e-01	-0.058100	8.03e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	89	3.45e-01	-0.058000	5.65e-01
Signaling by Retinoic Acid	25	6.21e-01	-0.057100	7.95e-01
Synthesis of PIPs at the Golgi membrane	14	7.12e-01	-0.057100	8.49e-01
SUMOylation of transcription factors	14	7.14e-01	-0.056700	8.50e-01
SUMOylation of SUMOylation proteins	34	5.68e-01	-0.056700	7.56e-01
Potassium Channels	20	6.61e-01	0.056700	8.20e-01
ATF6 (ATF6-alpha) activates chaperones	12	7.34e-01	0.056600	8.62e-01
Apoptosis	145	2.41e-01	0.056600	4.69e-01
NOD1/2 Signaling Pathway	31	5.86e-01	-0.056500	7.67e-01
Cilium Assembly	149	2.36e-01	0.056500	4.65e-01
Interleukin-17 signaling	59	4.55e-01	-0.056300	6.67e-01
Cholesterol biosynthesis	25	6.30e-01	-0.055700	8.03e-01
DNA Damage/Telomere Stress Induced Senescence	23	6.44e-01	-0.055700	8.10e-01
IRE1alpha activates chaperones	43	5.29e-01	0.055500	7.24e-01
Signaling by FLT3 ITD and TKD mutants	14	7.21e-01	-0.055200	8.54e-01
MAP kinase activation	57	4.72e-01	-0.055200	6.80e-01
Glycerophospholipid biosynthesis	78	4.03e-01	0.054900	6.16e-01
Muscle contraction	68	4.36e-01	-0.054700	6.50e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	7.14e-01	-0.054700	8.50e-01
Separation of Sister Chromatids	146	2.56e-01	0.054600	4.85e-01
Beta-catenin independent WNT signaling	105	3.35e-01	0.054600	5.55e-01
Programmed Cell Death	174	2.17e-01	0.054500	4.42e-01
Antiviral mechanism by IFN-stimulated genes	128	2.89e-01	-0.054400	5.12e-01
Processing of DNA double-strand break ends	51	5.03e-01	-0.054200	7.03e-01
VEGFR2 mediated vascular permeability	21	6.67e-01	-0.054200	8.25e-01
Interleukin-12 signaling	37	5.70e-01	-0.054000	7.57e-01
Macroautophagy	117	3.20e-01	-0.053300	5.39e-01
Negative regulation of the PI3K/AKT network	56	4.92e-01	-0.053200	6.96e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	5.93e-01	-0.053000	7.73e-01
Interleukin-1 signaling	104	3.53e-01	0.052900	5.75e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	7.72e-01	-0.052800	8.86e-01
Synthesis of bile acids and bile salts	17	7.09e-01	-0.052300	8.47e-01
RHOQ GTPase cycle	45	5.45e-01	-0.052200	7.38e-01
Metabolism of porphyrins	19	6.94e-01	0.052100	8.42e-01
G alpha (q) signalling events	72	4.46e-01	-0.052000	6.59e-01
Toll Like Receptor 9 (TLR9) Cascade	94	3.88e-01	-0.051600	6.01e-01
Transcriptional regulation by RUNX3	86	4.14e-01	0.051100	6.28e-01
Nucleotide Excision Repair	104	3.76e-01	0.050400	5.91e-01
M Phase	292	1.43e-01	0.050200	3.38e-01
mRNA Splicing - Minor Pathway	50	5.40e-01	-0.050200	7.34e-01
Signaling by Insulin receptor	48	5.48e-01	-0.050200	7.41e-01
MyD88 dependent cascade initiated on endosome	90	4.13e-01	-0.050100	6.28e-01
Bile acid and bile salt metabolism	19	7.07e-01	-0.049800	8.47e-01
ISG15 antiviral mechanism	71	4.71e-01	-0.049500	6.80e-01
WNT5A-dependent internalization of FZD4	12	7.68e-01	0.049300	8.85e-01
MyD88-independent TLR4 cascade	97	4.03e-01	-0.049200	6.16e-01
TRIF(TICAM1)-mediated TLR4 signaling	97	4.03e-01	-0.049200	6.16e-01
Post-translational modification: synthesis of GPI-anchored proteins	39	5.96e-01	-0.049100	7.76e-01
Diseases of mitotic cell cycle	31	6.37e-01	0.049100	8.06e-01
Nuclear Envelope Breakdown	47	5.63e-01	-0.048800	7.51e-01
Mitotic Prometaphase	151	3.03e-01	-0.048700	5.26e-01
Interleukin-6 family signaling	10	7.91e-01	-0.048500	8.96e-01
Triglyceride metabolism	20	7.08e-01	-0.048300	8.47e-01
Formation of TC-NER Pre-Incision Complex	53	5.43e-01	0.048300	7.36e-01
Rab regulation of trafficking	113	3.79e-01	0.048000	5.92e-01
Inwardly rectifying K+ channels	11	7.83e-01	0.048000	8.91e-01
Export of Viral Ribonucleoproteins from Nucleus	32	6.41e-01	-0.047700	8.09e-01
Signaling by Hippo	13	7.66e-01	-0.047700	8.85e-01
RNA Polymerase I Transcription Initiation	40	6.04e-01	-0.047500	7.82e-01
Neurexins and neuroligins	21	7.07e-01	-0.047400	8.47e-01
mTORC1-mediated signalling	24	6.89e-01	0.047300	8.39e-01
Ion channel transport	88	4.44e-01	-0.047300	6.57e-01
Transcriptional activation of mitochondrial biogenesis	46	5.80e-01	-0.047200	7.64e-01
Signal amplification	20	7.17e-01	-0.046800	8.53e-01
Maturation of nucleoprotein 9683610	11	7.90e-01	-0.046400	8.96e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	10	8.02e-01	-0.045800	9.04e-01
Heparan sulfate/heparin (HS-GAG) metabolism	27	6.81e-01	0.045700	8.33e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	29	6.71e-01	-0.045600	8.26e-01
Mitotic Anaphase	185	2.87e-01	0.045600	5.10e-01
Mitotic Metaphase and Anaphase	185	2.87e-01	0.045600	5.10e-01
G beta:gamma signalling through CDC42	12	7.85e-01	0.045500	8.92e-01
CD209 (DC-SIGN) signaling	16	7.54e-01	-0.045300	8.76e-01
Recruitment of NuMA to mitotic centrosomes	74	5.02e-01	-0.045300	7.03e-01
DCC mediated attractive signaling	10	8.04e-01	-0.045200	9.05e-01
Transcription of E2F targets under negative control by DREAM complex	13	7.79e-01	-0.044900	8.91e-01
Metabolism of non-coding RNA	50	5.84e-01	0.044800	7.67e-01
snRNP Assembly	50	5.84e-01	0.044800	7.67e-01
Transport of Mature mRNA Derived from an Intronless Transcript	41	6.20e-01	-0.044800	7.95e-01
Processing of Intronless Pre-mRNAs	20	7.31e-01	-0.044400	8.60e-01
RNA Polymerase I Promoter Clearance	44	6.12e-01	-0.044300	7.88e-01
RNA Polymerase I Transcription	44	6.12e-01	-0.044300	7.88e-01
Activation of kainate receptors upon glutamate binding	13	7.83e-01	0.044100	8.91e-01
HS-GAG biosynthesis	15	7.67e-01	0.044100	8.85e-01
Activation of gene expression by SREBF (SREBP)	40	6.30e-01	-0.044100	8.03e-01
Telomere Extension By Telomerase	17	7.54e-01	-0.043900	8.76e-01
Insulin receptor recycling	22	7.23e-01	0.043700	8.56e-01
VxPx cargo-targeting to cilium	17	7.58e-01	0.043300	8.78e-01
Host Interactions of HIV factors	129	4.00e-01	0.043000	6.15e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	33	6.71e-01	0.042800	8.26e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	10	8.15e-01	-0.042800	9.05e-01
TNFR1-induced proapoptotic signaling	23	7.25e-01	0.042400	8.57e-01
Late SARS-CoV-2 Infection Events	58	5.77e-01	-0.042400	7.63e-01
Oxidative Stress Induced Senescence	56	5.85e-01	-0.042300	7.67e-01
Extension of Telomeres	40	6.46e-01	0.042000	8.11e-01
RND3 GTPase cycle	27	7.06e-01	-0.041900	8.47e-01
TNFs bind their physiological receptors	10	8.20e-01	0.041700	9.05e-01
Cleavage of the damaged purine	10	8.20e-01	-0.041600	9.05e-01
Depurination	10	8.20e-01	-0.041600	9.05e-01
Recognition and association of DNA glycosylase with site containing an affected purine	10	8.20e-01	-0.041600	9.05e-01
Adrenaline,noradrenaline inhibits insulin secretion	10	8.21e-01	-0.041400	9.05e-01
Cytosolic iron-sulfur cluster assembly	10	8.22e-01	0.041200	9.05e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	34	6.78e-01	-0.041200	8.31e-01
CLEC7A (Dectin-1) signaling	93	4.94e-01	0.041100	6.98e-01
GABA receptor activation	17	7.70e-01	-0.041000	8.85e-01
Regulation of PTEN gene transcription	53	6.07e-01	0.040900	7.85e-01
Signaling by KIT in disease	17	7.71e-01	-0.040800	8.85e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	17	7.71e-01	-0.040800	8.85e-01
Glycogen metabolism	20	7.53e-01	0.040600	8.76e-01
Membrane Trafficking	496	1.28e-01	0.040400	3.14e-01
XBP1(S) activates chaperone genes	41	6.55e-01	0.040400	8.18e-01
HDR through Single Strand Annealing (SSA)	29	7.08e-01	-0.040300	8.47e-01
SUMOylation of DNA damage response and repair proteins	73	5.53e-01	-0.040200	7.43e-01
Class A/1 (Rhodopsin-like receptors)	51	6.20e-01	0.040100	7.95e-01
COPI-dependent Golgi-to-ER retrograde traffic	67	5.73e-01	0.039900	7.59e-01
FOXO-mediated transcription of cell cycle genes	11	8.22e-01	0.039200	9.05e-01
Insulin processing	16	7.89e-01	0.038700	8.95e-01
MTOR signalling	39	6.77e-01	-0.038600	8.31e-01
Interactions of Rev with host cellular proteins	36	6.89e-01	-0.038600	8.39e-01
Cellular Senescence	106	4.95e-01	-0.038500	6.98e-01
MET promotes cell motility	18	7.80e-01	-0.038000	8.91e-01
Processing of SMDT1	14	8.06e-01	0.037900	9.05e-01
Regulation of insulin secretion	35	6.98e-01	-0.037900	8.45e-01
Kinesins	29	7.25e-01	-0.037800	8.57e-01
Transcriptional Regulation by E2F6	30	7.21e-01	-0.037800	8.54e-01
NCAM signaling for neurite out-growth	22	7.60e-01	-0.037700	8.80e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	42	6.76e-01	-0.037300	8.31e-01
Biological oxidations	84	5.56e-01	0.037300	7.45e-01
HATs acetylate histones	75	5.79e-01	-0.037100	7.64e-01
Plasma lipoprotein remodeling	13	8.17e-01	-0.037000	9.05e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	21	7.70e-01	-0.036900	8.85e-01
Transcriptional regulation by RUNX1	139	4.60e-01	0.036400	6.72e-01
C-type lectin receptors (CLRs)	110	5.14e-01	0.036100	7.12e-01
Downstream signaling of activated FGFR2	11	8.37e-01	-0.035900	9.11e-01
Downstream signaling of activated FGFR3	11	8.37e-01	-0.035900	9.11e-01
Downstream signaling of activated FGFR4	11	8.37e-01	-0.035900	9.11e-01
Defective pyroptosis	13	8.23e-01	0.035900	9.05e-01
Presynaptic phase of homologous DNA pairing and strand exchange	31	7.30e-01	0.035800	8.60e-01
A tetrasaccharide linker sequence is required for GAG synthesis	11	8.37e-01	0.035800	9.11e-01
Cell Cycle, Mitotic	389	2.35e-01	0.035400	4.65e-01
Glyoxylate metabolism and glycine degradation	21	7.81e-01	-0.035100	8.91e-01
Transport to the Golgi and subsequent modification	144	4.73e-01	0.034800	6.80e-01
KEAP1-NFE2L2 pathway	114	5.23e-01	0.034700	7.18e-01
CD28 co-stimulation	27	7.56e-01	-0.034600	8.77e-01
Tie2 Signaling	13	8.29e-01	-0.034600	9.08e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	8.17e-01	0.034500	9.05e-01
p130Cas linkage to MAPK signaling for integrins	10	8.51e-01	0.034300	9.23e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	44	6.95e-01	-0.034300	8.42e-01
HCMV Late Events	53	6.68e-01	0.034100	8.25e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	7.78e-01	0.034000	8.91e-01
PIP3 activates AKT signaling	198	4.14e-01	0.033800	6.28e-01
Glycolysis	61	6.54e-01	-0.033300	8.17e-01
Processive synthesis on the C-strand of the telomere	18	8.08e-01	-0.033200	9.05e-01
CD28 dependent PI3K/Akt signaling	19	8.03e-01	0.033100	9.04e-01
TCF dependent signaling in response to WNT	117	5.40e-01	0.032900	7.34e-01
Synthesis of glycosylphosphatidylinositol (GPI)	16	8.22e-01	0.032600	9.05e-01
Signaling by NOTCH	148	4.99e-01	-0.032300	7.00e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	75	6.35e-01	0.031800	8.06e-01
MAPK family signaling cascades	198	4.43e-01	-0.031700	6.56e-01
Metabolism of proteins	1340	6.33e-02	-0.031300	2.08e-01
Interleukin-1 family signaling	123	5.51e-01	0.031200	7.43e-01
Phospholipid metabolism	144	5.24e-01	-0.030900	7.18e-01
Base Excision Repair	40	7.36e-01	0.030800	8.62e-01
Cell Cycle	478	2.58e-01	0.030500	4.87e-01
Signaling by the B Cell Receptor (BCR)	101	5.97e-01	0.030500	7.76e-01
ER to Golgi Anterograde Transport	124	5.63e-01	0.030100	7.51e-01
Transcriptional Regulation by MECP2	38	7.51e-01	-0.029800	8.75e-01
Transport of the SLBP independent Mature mRNA	34	7.64e-01	-0.029700	8.84e-01
Vesicle-mediated transport	514	2.56e-01	0.029600	4.85e-01
Nicotinamide salvaging	13	8.54e-01	0.029600	9.23e-01
Signaling by NOTCH4	75	6.61e-01	0.029300	8.20e-01
SUMOylation of chromatin organization proteins	53	7.18e-01	-0.028700	8.53e-01
Regulation of TP53 Activity through Phosphorylation	71	6.77e-01	0.028700	8.31e-01
Mitotic Spindle Checkpoint	80	6.59e-01	0.028600	8.20e-01
Synthesis of very long-chain fatty acyl-CoAs	15	8.51e-01	-0.028000	9.23e-01
ER-Phagosome pathway	83	6.62e-01	0.027800	8.20e-01
GAB1 signalosome	10	8.80e-01	-0.027600	9.36e-01
Transferrin endocytosis and recycling	22	8.23e-01	0.027500	9.05e-01
Ion transport by P-type ATPases	30	7.95e-01	-0.027500	9.00e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	65	7.03e-01	-0.027400	8.47e-01
Amplification of signal from the kinetochores	65	7.03e-01	-0.027400	8.47e-01
G2/M DNA damage checkpoint	49	7.48e-01	0.026500	8.74e-01
Inhibition of DNA recombination at telomere	21	8.37e-01	-0.026000	9.11e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	29	8.09e-01	-0.025900	9.05e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	29	8.09e-01	-0.025900	9.05e-01
APC/C:Cdc20 mediated degradation of Cyclin B	20	8.42e-01	0.025800	9.15e-01
Ion homeostasis	27	8.20e-01	-0.025300	9.05e-01
Nuclear import of Rev protein	33	8.05e-01	-0.024900	9.05e-01
ECM proteoglycans	17	8.60e-01	-0.024600	9.23e-01
NEP/NS2 Interacts with the Cellular Export Machinery	31	8.18e-01	-0.023900	9.05e-01
DNA strand elongation	21	8.49e-01	0.023900	9.23e-01
Transport of Ribonucleoproteins into the Host Nucleus	31	8.18e-01	-0.023900	9.05e-01
Resolution of Abasic Sites (AP sites)	33	8.15e-01	0.023500	9.05e-01
Gastrin-CREB signalling pathway via PKC and MAPK	14	8.80e-01	-0.023300	9.36e-01
Meiotic synapsis	20	8.57e-01	0.023200	9.23e-01
ERKs are inactivated	12	8.90e-01	0.023000	9.36e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	13	8.86e-01	0.023000	9.36e-01
Mitotic Prophase	76	7.32e-01	0.022800	8.60e-01
HDR through Homologous Recombination (HRR)	50	7.83e-01	-0.022500	8.91e-01
Hedgehog ‘off’ state	87	7.18e-01	0.022500	8.53e-01
Telomere Maintenance	55	7.74e-01	0.022500	8.87e-01
Regulation of TP53 Activity	130	6.60e-01	-0.022400	8.20e-01
Viral Messenger RNA Synthesis	43	8.01e-01	-0.022300	9.03e-01
Signaling by ERBB2 TMD/JMD mutants	10	9.03e-01	-0.022200	9.44e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	17	8.76e-01	0.021900	9.35e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	13	8.91e-01	0.021900	9.36e-01
Cellular response to chemical stress	187	6.08e-01	-0.021900	7.86e-01
Gene expression (Transcription)	1074	2.40e-01	-0.021800	4.67e-01
Metabolism of steroids	101	7.06e-01	0.021700	8.47e-01
Transport of vitamins, nucleosides, and related molecules	25	8.54e-01	-0.021300	9.23e-01
RNA Polymerase II Transcription	935	2.83e-01	-0.021200	5.10e-01
Transport of the SLBP Dependant Mature mRNA	35	8.28e-01	-0.021200	9.08e-01
RHO GTPases activate PAKs	16	8.85e-01	0.020900	9.36e-01
MAPK targets/ Nuclear events mediated by MAP kinases	27	8.52e-01	0.020700	9.23e-01
Golgi Associated Vesicle Biogenesis	51	8.00e-01	0.020600	9.03e-01
Gluconeogenesis	24	8.65e-01	-0.020000	9.26e-01
DNA Damage Recognition in GG-NER	37	8.34e-01	0.019900	9.11e-01
Keratan sulfate/keratin metabolism	18	8.89e-01	0.019100	9.36e-01
COPI-mediated anterograde transport	80	7.69e-01	0.019000	8.85e-01
Glycosphingolipid metabolism	31	8.55e-01	-0.018900	9.23e-01
Thromboxane signalling through TP receptor	14	9.02e-01	-0.018900	9.44e-01
ER Quality Control Compartment (ERQC)	20	8.84e-01	-0.018800	9.36e-01
Sphingolipid metabolism	63	7.99e-01	0.018600	9.03e-01
Carnitine metabolism	11	9.16e-01	0.018400	9.52e-01
Metabolism of carbohydrates	197	6.61e-01	-0.018200	8.20e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	53	8.20e-01	-0.018100	9.05e-01
Complex I biogenesis	57	8.15e-01	-0.018000	9.05e-01
Dual Incision in GG-NER	37	8.53e-01	-0.017700	9.23e-01
G alpha (z) signalling events	23	8.84e-01	-0.017600	9.36e-01
RNA Polymerase I Promoter Escape	26	8.78e-01	0.017400	9.36e-01
G beta:gamma signalling through BTK	10	9.25e-01	-0.017200	9.54e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	21	8.92e-01	0.017100	9.36e-01
Regulated Necrosis	52	8.36e-01	0.016600	9.11e-01
Protein-protein interactions at synapses	32	8.71e-01	0.016600	9.32e-01
Signaling by FGFR2 in disease	25	8.87e-01	-0.016400	9.36e-01
Processing of Capped Intronless Pre-mRNA	27	8.84e-01	0.016200	9.36e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	19	9.04e-01	-0.016000	9.44e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	10	9.30e-01	-0.016000	9.56e-01
Disorders of Developmental Biology	11	9.27e-01	-0.016000	9.54e-01
Disorders of Nervous System Development	11	9.27e-01	-0.016000	9.54e-01
Loss of function of MECP2 in Rett syndrome	11	9.27e-01	-0.016000	9.54e-01
Pervasive developmental disorders	11	9.27e-01	-0.016000	9.54e-01
Integration of energy metabolism	56	8.37e-01	0.015900	9.11e-01
Cardiac conduction	41	8.60e-01	-0.015900	9.23e-01
RAF/MAP kinase cascade	164	7.27e-01	-0.015900	8.58e-01
RNA polymerase II transcribes snRNA genes	68	8.24e-01	-0.015600	9.05e-01
Downstream TCR signaling	84	8.06e-01	0.015500	9.05e-01
Deubiquitination	206	7.06e-01	-0.015300	8.47e-01
Chromosome Maintenance	73	8.23e-01	-0.015200	9.05e-01
Platelet homeostasis	44	8.64e-01	0.014900	9.26e-01
Deadenylation-dependent mRNA decay	49	8.60e-01	-0.014600	9.23e-01
Intracellular signaling by second messengers	224	7.11e-01	0.014400	8.49e-01
Transport of small molecules	391	6.29e-01	-0.014400	8.03e-01
Signaling by WNT	178	7.49e-01	0.014000	8.74e-01
Post-translational protein phosphorylation	43	8.76e-01	-0.013700	9.35e-01
SUMOylation of DNA replication proteins	39	8.83e-01	-0.013700	9.36e-01
Signaling by Hedgehog	108	8.07e-01	0.013600	9.05e-01
Fc epsilon receptor (FCERI) signaling	117	8.00e-01	-0.013600	9.03e-01
Diseases of programmed cell death	39	8.84e-01	-0.013500	9.36e-01
Formation of Incision Complex in GG-NER	41	8.82e-01	0.013400	9.36e-01
Nuclear events mediated by NFE2L2	89	8.28e-01	0.013400	9.08e-01
Gene Silencing by RNA	66	8.57e-01	-0.012800	9.23e-01
Regulation of HSF1-mediated heat shock response	70	8.55e-01	-0.012600	9.23e-01
MAPK1/MAPK3 signaling	168	7.82e-01	-0.012400	8.91e-01
Organelle biogenesis and maintenance	230	7.52e-01	0.012200	8.76e-01
Postmitotic nuclear pore complex (NPC) reformation	25	9.18e-01	-0.012000	9.52e-01
Metabolism	1413	4.72e-01	-0.011900	6.80e-01
Homology Directed Repair	80	8.56e-01	-0.011800	9.23e-01
Visual phototransduction	41	8.99e-01	-0.011400	9.42e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	32	9.13e-01	0.011200	9.50e-01
Diseases of DNA Double-Strand Break Repair	32	9.13e-01	0.011200	9.50e-01
PKR-mediated signaling	57	8.85e-01	-0.011100	9.36e-01
Fatty acyl-CoA biosynthesis	23	9.27e-01	-0.011100	9.54e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	11	9.50e-01	-0.011000	9.69e-01
Association of TriC/CCT with target proteins during biosynthesis	30	9.18e-01	-0.010900	9.52e-01
Signaling by WNT in cancer	18	9.37e-01	-0.010800	9.58e-01
Peroxisomal protein import	52	8.96e-01	-0.010500	9.39e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	41	9.09e-01	0.010300	9.48e-01
Post-translational protein modification	980	5.97e-01	0.010200	7.76e-01
SUMOylation of RNA binding proteins	44	9.07e-01	-0.010200	9.47e-01
trans-Golgi Network Vesicle Budding	65	8.88e-01	-0.010100	9.36e-01
RAB GEFs exchange GTP for GDP on RABs	81	8.76e-01	0.010000	9.35e-01
Transcriptional Regulation by TP53	312	7.63e-01	0.010000	8.83e-01
Golgi-to-ER retrograde transport	98	8.65e-01	0.009970	9.26e-01
RNA Polymerase I Transcription Termination	24	9.34e-01	0.009810	9.58e-01
tRNA processing	112	8.58e-01	0.009800	9.23e-01
Signaling by NODAL	12	9.54e-01	-0.009660	9.69e-01
SUMOylation of ubiquitinylation proteins	38	9.20e-01	-0.009410	9.54e-01
Class I MHC mediated antigen processing & presentation	316	7.83e-01	-0.009090	8.91e-01
Maturation of spike protein 9694548	34	9.28e-01	-0.008980	9.54e-01
FGFR2 mutant receptor activation	16	9.52e-01	0.008670	9.69e-01
Signaling by FGFR2 IIIa TM	16	9.52e-01	0.008670	9.69e-01
NS1 Mediated Effects on Host Pathways	39	9.26e-01	-0.008610	9.54e-01
Generic Transcription Pathway	822	6.95e-01	-0.008230	8.42e-01
MicroRNA (miRNA) biogenesis	23	9.46e-01	0.008220	9.66e-01
Branched-chain amino acid catabolism	21	9.49e-01	0.008050	9.69e-01
G1/S-Specific Transcription	15	9.57e-01	-0.008040	9.70e-01
Rev-mediated nuclear export of HIV RNA	34	9.37e-01	-0.007840	9.58e-01
Diseases of DNA repair	40	9.35e-01	-0.007440	9.58e-01
Glucose metabolism	76	9.17e-01	-0.006920	9.52e-01
Transcriptional regulation by small RNAs	47	9.35e-01	-0.006860	9.58e-01
Ub-specific processing proteases	140	8.91e-01	-0.006710	9.36e-01
Cargo concentration in the ER	24	9.55e-01	0.006620	9.69e-01
Removal of the Flap Intermediate from the C-strand	16	9.63e-01	0.006610	9.75e-01
Impaired BRCA2 binding to RAD51	27	9.53e-01	0.006590	9.69e-01
Centrosome maturation	70	9.28e-01	-0.006300	9.54e-01
Recruitment of mitotic centrosome proteins and complexes	70	9.28e-01	-0.006300	9.54e-01
Nucleotide catabolism	25	9.57e-01	0.006250	9.70e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	75	9.32e-01	-0.005670	9.58e-01
Early SARS-CoV-2 Infection Events	28	9.59e-01	0.005580	9.71e-01
DNA Repair	242	8.89e-01	0.005230	9.36e-01
Sialic acid metabolism	23	9.67e-01	-0.005020	9.77e-01
Reproduction	46	9.54e-01	0.004960	9.69e-01
Vasopressin regulates renal water homeostasis via Aquaporins	21	9.69e-01	-0.004940	9.77e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	50	9.53e-01	0.004830	9.69e-01
Energy dependent regulation of mTOR by LKB1-AMPK	27	9.68e-01	0.004530	9.77e-01
Homologous DNA Pairing and Strand Exchange	33	9.67e-01	-0.004140	9.77e-01
Metabolism of lipids	493	9.00e-01	-0.003360	9.42e-01
RND1 GTPase cycle	27	9.79e-01	-0.002940	9.84e-01
rRNA modification in the nucleus and cytosol	55	9.71e-01	-0.002880	9.78e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	61	9.71e-01	-0.002680	9.78e-01
Aquaporin-mediated transport	22	9.86e-01	-0.002190	9.89e-01
Dual incision in TC-NER	62	9.80e-01	0.001890	9.84e-01
Anchoring of the basal body to the plasma membrane	81	9.79e-01	-0.001710	9.84e-01
Glycosaminoglycan metabolism	67	9.84e-01	-0.001420	9.88e-01
Diseases associated with O-glycosylation of proteins	15	9.94e-01	0.001080	9.96e-01
ERK/MAPK targets	19	9.95e-01	-0.000886	9.96e-01
Phase I - Functionalization of compounds	36	9.96e-01	-0.000526	9.96e-01
Mismatch Repair	14	9.99e-01	0.000240	9.99e-01

---

Detailed Gene set reports

Peptide chain elongation

Peptide chain elongation

	745
set	Peptide chain elongation
setSize	87
pANOVA	1.72e-30
s.dist	-0.711
p.adjustANOVA	4.45e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
EEF2	-5167
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
EEF1A1	-5006
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
RPS26	-3459
RPS2	-3043
RPL27	315
RPS17	512
RPS20	1429
RPL35	2495
RPL9	3470
RPL39L	3526
RPL26L1	4044
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	318
set	Eukaryotic Translation Elongation
setSize	90
pANOVA	6.54e-31
s.dist	-0.704
p.adjustANOVA	2.12e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
EEF2	-5167
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
EEF1A1	-5006
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
EEF1B2	-4363
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
EEF1G	-3972
RPS6	-3879
RPS27A	-3866
RPS26	-3459
RPS2	-3043
EEF1D	169
RPL27	315
RPS17	512
RPS20	1429
RPL35	2495
RPL9	3470
RPL39L	3526
RPL26L1	4044
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Viral mRNA Translation

Viral mRNA Translation

	1254
set	Viral mRNA Translation
setSize	87
pANOVA	1.78e-29
s.dist	-0.699
p.adjustANOVA	2.89e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
GRSF1	-4387
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
RPS26	-3459
RPS2	-3043
DNAJC3	29
RPL27	315
RPS17	512
RPS20	1429
RPL35	2495
RPL9	3470
RPL39L	3526
RPL26L1	4044
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Translocation of ZAP-70 to Immunological synapse

Translocation of ZAP-70 to Immunological synapse

	1221
set	Translocation of ZAP-70 to Immunological synapse
setSize	10
pANOVA	0.000137
s.dist	-0.697
p.adjustANOVA	0.00211

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD4	-5320
HLA-DRB1	-5206
HLA-DPA1	-5176
HLA-DPB1	-5122
HLA-DRA	-5064
PTPN22	-4647
HLA-DRB5	-2598
HLA-DQA2	-2564
HLA-DQA1	-1299
HLA-DQB1	-900

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD4	-5320
HLA-DRB1	-5206
HLA-DPA1	-5176
HLA-DPB1	-5122
HLA-DRA	-5064
PTPN22	-4647
HLA-DRB5	-2598
HLA-DQA2	-2564
HLA-DQA1	-1299
HLA-DQB1	-900

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	355
set	Formation of a pool of free 40S subunits
setSize	98
pANOVA	9.6e-32
s.dist	-0.685
p.adjustANOVA	6.26e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
EIF3E	-5343
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
EIF3H	-5057
RPL17	-5043
EIF3G	-5021
RPS29	-5016
RPL19	-5013
EIF3K	-4970
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
EIF3L	-4845
EIF3A	-4833
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
EIF3F	-4665
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
EIF3D	-4410
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
EIF3M	-3823
RPS26	-3459
RPS2	-3043
EIF3J	-623
EIF3B	-494
RPL27	315
RPS17	512
EIF3I	772
RPS20	1429
RPL35	2495
RPL9	3470
RPL39L	3526
RPL26L1	4044
EIF1AX	5020
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery

	970
set	SARS-CoV-1 modulates host translation machinery
setSize	36
pANOVA	1.92e-12
s.dist	-0.678
p.adjustANOVA	7.75e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
FAU	-5214
RPS16	-5154
HNRNPA1	-5058
RPS29	-5016
EEF1A1	-5006
RPS3	-4880

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
FAU	-5214
RPS16	-5154
HNRNPA1	-5058
RPS29	-5016
EEF1A1	-5006
RPS3	-4880
RPS28	-4714
RPS27	-4582
RPS7	-4508
RPS10	-4485
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPS6	-3879
RPS27A	-3866
RPS26	-3459
RPS2	-3043
RPS17	512
RPS20	1429
RPSA	5189
RPS27L	5275
RPS19	5283

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	541
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	108
pANOVA	9.67e-32
s.dist	-0.653
p.adjustANOVA	6.26e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
EIF3E	-5343
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
EIF4B	-5262
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
EIF4A2	-5219
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
EIF3H	-5057
EIF4A1	-5053
RPL17	-5043
EIF3G	-5021
RPS29	-5016
RPL19	-5013
PABPC1	-4976
EIF3K	-4970
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
EIF3L	-4845
EIF3A	-4833
RPL31	-4801
EIF2S3	-4783
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
EIF3F	-4665
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
EIF3D	-4410
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
EIF3M	-3823
RPS26	-3459
RPS2	-3043
EIF3J	-623
EIF3B	-494
EIF4E	-295
EIF2S1	314
RPL27	315
RPS17	512
EIF4G1	767
EIF3I	772
EIF4H	1327
RPS20	1429
RPL35	2495
RPL9	3470
RPL39L	3526
RPL26L1	4044
EIF1AX	5020
EIF2S2	5025
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	396
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	109
pANOVA	2.24e-31
s.dist	-0.646
p.adjustANOVA	9.65e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
EIF3E	-5343
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
EIF4B	-5262
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
EIF4A2	-5219
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
EIF3H	-5057
EIF4A1	-5053
RPL17	-5043
EIF3G	-5021
RPS29	-5016
RPL19	-5013
EIF3K	-4970
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
EIF3L	-4845
EIF3A	-4833
RPL31	-4801
EIF2S3	-4783
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
EIF3F	-4665
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
EIF3D	-4410
EIF5	-4379
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
EIF3M	-3823
RPS26	-3459
RPS2	-3043
EIF3J	-623
EIF3B	-494
EIF4E	-295
EIF5B	-102
EIF2S1	314
RPL27	315
RPS17	512
EIF4G1	767
EIF3I	772
EIF4H	1327
RPS20	1429
RPL35	2495
RPL9	3470
RPL39L	3526
RPL26L1	4044
EIF1AX	5020
EIF2S2	5025
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Selenocysteine synthesis

Selenocysteine synthesis

	1006
set	Selenocysteine synthesis
setSize	90
pANOVA	9.67e-26
s.dist	-0.639
p.adjustANOVA	1.14e-23

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
RPS26	-3459
RPS2	-3043
RPL27	315
RPS17	512
PSTK	795
SEPSECS	1381
RPS20	1429
EEFSEC	2109
RPL35	2495
RPL9	3470
RPL39L	3526
SECISBP2	3873
RPL26L1	4044
SEPHS2	4531
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Generation of second messenger molecules

Generation of second messenger molecules

	407
set	Generation of second messenger molecules
setSize	18
pANOVA	2.7e-06
s.dist	-0.639
p.adjustANOVA	6.73e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EVL	-5365
CD4	-5320
HLA-DRB1	-5206
HLA-DPA1	-5176
NCK1	-5128
HLA-DPB1	-5122
HLA-DRA	-5064
WAS	-4769
LCP2	-4295
PAK2	-4173
PLCG2	-4081
LAT	-3713
HLA-DRB5	-2598
HLA-DQA2	-2564
HLA-DQA1	-1299
HLA-DQB1	-900
VASP	-609
PAK1	2775

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EVL	-5365
CD4	-5320
HLA-DRB1	-5206
HLA-DPA1	-5176
NCK1	-5128
HLA-DPB1	-5122
HLA-DRA	-5064
WAS	-4769
LCP2	-4295
PAK2	-4173
PLCG2	-4081
LAT	-3713
HLA-DRB5	-2598
HLA-DQA2	-2564
HLA-DQA1	-1299
HLA-DQB1	-900
VASP	-609
PAK1	2775

---

FASTK family proteins regulate processing and stability of mitochondrial RNAs

FASTK family proteins regulate processing and stability of mitochondrial RNAs

	325
set	FASTK family proteins regulate processing and stability of mitochondrial RNAs
setSize	17
pANOVA	5.18e-06
s.dist	-0.638
p.adjustANOVA	0.000127

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-CO2	-5354
MT-CO1	-5257
MT-ND4L	-5230
MT-ND3	-5198
MT-ND4	-5124
MT-CYB	-5047
MT-ND5	-5014
MT-ND2	-4983
MT-CO3	-4913
MT-ATP6	-4607
MT-ND6	-4575
MT-ATP8	-3734
MT-ND1	-3630
TBRG4	-2161
FASTKD5	-889
FASTK	2573
FASTKD2	4046

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-CO2	-5354
MT-CO1	-5257
MT-ND4L	-5230
MT-ND3	-5198
MT-ND4	-5124
MT-CYB	-5047
MT-ND5	-5014
MT-ND2	-4983
MT-CO3	-4913
MT-ATP6	-4607
MT-ND6	-4575
MT-ATP8	-3734
MT-ND1	-3630
TBRG4	-2161
FASTKD5	-889
FASTK	2573
FASTKD2	4046

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	687
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	93
pANOVA	8.92e-26
s.dist	-0.63
p.adjustANOVA	1.14e-23

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
PABPC1	-4976
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
RPS26	-3459
RPS2	-3043
UPF1	-311
RPL27	315
RPS17	512
NCBP2	598
EIF4G1	767
NCBP1	1114
RPS20	1429
GSPT2	2028
RPL35	2495
RPL9	3470
RPL39L	3526
GSPT1	3600
RPL26L1	4044
ETF1	4449
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Chemokine receptors bind chemokines

Chemokine receptors bind chemokines

	158
set	Chemokine receptors bind chemokines
setSize	10
pANOVA	0.000662
s.dist	0.622
p.adjustANOVA	0.0081

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCL3	5266
CCL3L1	5048
CCRL2	4610
CCL7	4401
CCR1	4313
CCL2	4175
CCL22	4039
CXCL16	3801
CCR5	-714
CXCR4	-2280

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCL3	5266
CCL3L1	5048
CCRL2	4610
CCL7	4401
CCR1	4313
CCL2	4175
CCL22	4039
CXCL16	3801
CCR5	-714
CXCR4	-2280

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	986
set	SRP-dependent cotranslational protein targeting to membrane
setSize	109
pANOVA	7.47e-29
s.dist	-0.618
p.adjustANOVA	1.07e-26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
SSR4	-5271
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
SEC11A	-5212
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
DDOST	-4689
RPL13	-4667
RPS27	-4582
SPCS2	-4551
TRAM1	-4534
RPS7	-4508
RPL15	-4489
RPS10	-4485
SSR2	-4438
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
SRP14	-4213
SSR3	-4118
RPS5	-4093
SRP9	-4041
RPL18A	-4001
SRP68	-3942
RPN1	-3934
RPS6	-3879
RPS27A	-3866
SSR1	-3796
SRPRB	-3581
RPS26	-3459
RPS2	-3043
SEC61A1	-2015
SPCS1	46
SRP19	292
RPL27	315
RPN2	370
RPS17	512
SEC61B	790
SRP72	1181
RPS20	1429
SEC61G	1457
RPL35	2495
SRPRA	2708
SRP54	3243
SPCS3	3430
RPL9	3470
RPL39L	3526
RPL26L1	4044
SEC11C	4974
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	320
set	Eukaryotic Translation Termination
setSize	91
pANOVA	2.37e-24
s.dist	-0.618
p.adjustANOVA	2.36e-22

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
RPS26	-3459
RPS2	-3043
RPL27	315
RPS17	512
N6AMT1	1316
RPS20	1429
GSPT2	2028
RPL35	2495
RPL9	3470
RPL39L	3526
GSPT1	3600
APEH	3855
RPL26L1	4044
ETF1	4449
TRMT112	4638
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

tRNA processing in the mitochondrion

tRNA processing in the mitochondrion

	1293
set	tRNA processing in the mitochondrion
setSize	18
pANOVA	6.92e-06
s.dist	-0.612
p.adjustANOVA	0.000166

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-CO2	-5354
MT-CO1	-5257
MT-ND4L	-5230
MT-ND3	-5198
MT-ND4	-5124
MT-CYB	-5047
MT-ND5	-5014
MT-ND2	-4983
MT-CO3	-4913
MT-ATP6	-4607
MT-ND6	-4575
MT-ATP8	-3734
MT-ND1	-3630
HSD17B10	-2451
PRORP	-1595
TRMT10C	-2
ELAC2	3327
TRNT1	3348

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-CO2	-5354
MT-CO1	-5257
MT-ND4L	-5230
MT-ND3	-5198
MT-ND4	-5124
MT-CYB	-5047
MT-ND5	-5014
MT-ND2	-4983
MT-CO3	-4913
MT-ATP6	-4607
MT-ND6	-4575
MT-ATP8	-3734
MT-ND1	-3630
HSD17B10	-2451
PRORP	-1595
TRMT10C	-2
ELAC2	3327
TRNT1	3348

---

Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains

	755
set	Phosphorylation of CD3 and TCR zeta chains
setSize	14
pANOVA	7.42e-05
s.dist	-0.612
p.adjustANOVA	0.00132

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PTPRC	-5331
CD4	-5320
HLA-DRB1	-5206
HLA-DPA1	-5176
HLA-DPB1	-5122
HLA-DRA	-5064
PTPN22	-4647
PTPRJ	-4344
CSK	-4187
HLA-DRB5	-2598
HLA-DQA2	-2564
HLA-DQA1	-1299
HLA-DQB1	-900
PAG1	5081

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PTPRC	-5331
CD4	-5320
HLA-DRB1	-5206
HLA-DPA1	-5176
HLA-DPB1	-5122
HLA-DRA	-5064
PTPN22	-4647
PTPRJ	-4344
CSK	-4187
HLA-DRB5	-2598
HLA-DQA2	-2564
HLA-DQA1	-1299
HLA-DQB1	-900
PAG1	5081

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

	955
set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	98
pANOVA	1.63e-25
s.dist	-0.61
p.adjustANOVA	1.76e-23

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
CEBPB	-5224
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
ATF3	-5007
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
RPL31	-4801
EIF2S3	-4783
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
RPS26	-3459
RPS2	-3043
ATF4	-1905
GCN1	-445
ATF2	-140
EIF2AK4	99
EIF2S1	314
RPL27	315
RPS17	512
IMPACT	551
RPS20	1429
DDIT3	1811
RPL35	2495
RPL9	3470
RPL39L	3526
RPL26L1	4044
EIF2S2	5025
CEBPG	5063
TRIB3	5146
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

	127
set	Cap-dependent Translation Initiation
setSize	116
pANOVA	1.32e-29
s.dist	-0.607
p.adjustANOVA	2.45e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
EIF3E	-5343
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
EIF4B	-5262
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
EIF4A2	-5219
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
EIF3H	-5057
EIF4A1	-5053
RPL17	-5043
EIF3G	-5021
RPS29	-5016
RPL19	-5013
PABPC1	-4976
EIF3K	-4970
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
EIF3L	-4845
EIF3A	-4833
RPL31	-4801
EIF2S3	-4783
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
EIF3F	-4665
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
EIF3D	-4410
EIF5	-4379
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
EIF3M	-3823
EIF2B2	-3787
RPS26	-3459
EIF2B1	-3079
RPS2	-3043
EIF2B5	-668
EIF3J	-623
EIF3B	-494
EIF4E	-295
EIF5B	-102
EIF2S1	314
RPL27	315
RPS17	512
EIF4G1	767
EIF3I	772
EIF4H	1327
RPS20	1429
RPL35	2495
RPL9	3470
RPL39L	3526
EIF2B3	3543
EIF2B4	3823
RPL26L1	4044
EIF4EBP1	4631
EIF1AX	5020
EIF2S2	5025
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

	319
set	Eukaryotic Translation Initiation
setSize	116
pANOVA	1.32e-29
s.dist	-0.607
p.adjustANOVA	2.45e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
EIF3E	-5343
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
EIF4B	-5262
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
EIF4A2	-5219
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
EIF3H	-5057
EIF4A1	-5053
RPL17	-5043
EIF3G	-5021
RPS29	-5016
RPL19	-5013
PABPC1	-4976
EIF3K	-4970
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
EIF3L	-4845
EIF3A	-4833
RPL31	-4801
EIF2S3	-4783
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
EIF3F	-4665
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
EIF3D	-4410
EIF5	-4379
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
EIF3M	-3823
EIF2B2	-3787
RPS26	-3459
EIF2B1	-3079
RPS2	-3043
EIF2B5	-668
EIF3J	-623
EIF3B	-494
EIF4E	-295
EIF5B	-102
EIF2S1	314
RPL27	315
RPS17	512
EIF4G1	767
EIF3I	772
EIF4H	1327
RPS20	1429
RPL35	2495
RPL9	3470
RPL39L	3526
EIF2B3	3543
EIF2B4	3823
RPL26L1	4044
EIF4EBP1	4631
EIF1AX	5020
EIF2S2	5025
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

	362
set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	50
pANOVA	5.67e-13
s.dist	-0.589
p.adjustANOVA	2.45e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
EIF3E	-5343
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
FAU	-5214
RPS16	-5154
EIF3H	-5057
EIF3G	-5021
RPS29	-5016

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
EIF3E	-5343
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
FAU	-5214
RPS16	-5154
EIF3H	-5057
EIF3G	-5021
RPS29	-5016
EIF3K	-4970
RPS3	-4880
EIF3L	-4845
EIF3A	-4833
EIF2S3	-4783
RPS28	-4714
EIF3F	-4665
RPS27	-4582
RPS7	-4508
RPS10	-4485
EIF3D	-4410
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPS6	-3879
RPS27A	-3866
EIF3M	-3823
RPS26	-3459
RPS2	-3043
EIF3J	-623
EIF3B	-494
EIF2S1	314
RPS17	512
EIF3I	772
RPS20	1429
EIF1AX	5020
EIF2S2	5025
RPSA	5189
RPS27L	5275
RPS19	5283

---

Translation initiation complex formation

Translation initiation complex formation

	1210
set	Translation initiation complex formation
setSize	57
pANOVA	4.7e-14
s.dist	-0.577
p.adjustANOVA	2.65e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
EIF3E	-5343
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
EIF4B	-5262
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
EIF4A2	-5219
FAU	-5214
RPS16	-5154
EIF3H	-5057

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
EIF3E	-5343
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
EIF4B	-5262
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
EIF4A2	-5219
FAU	-5214
RPS16	-5154
EIF3H	-5057
EIF4A1	-5053
EIF3G	-5021
RPS29	-5016
PABPC1	-4976
EIF3K	-4970
RPS3	-4880
EIF3L	-4845
EIF3A	-4833
EIF2S3	-4783
RPS28	-4714
EIF3F	-4665
RPS27	-4582
RPS7	-4508
RPS10	-4485
EIF3D	-4410
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPS6	-3879
RPS27A	-3866
EIF3M	-3823
RPS26	-3459
RPS2	-3043
EIF3J	-623
EIF3B	-494
EIF4E	-295
EIF2S1	314
RPS17	512
EIF4G1	767
EIF3I	772
EIF4H	1327
RPS20	1429
EIF1AX	5020
EIF2S2	5025
RPSA	5189
RPS27L	5275
RPS19	5283

---

Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition

	963
set	Ribosomal scanning and start codon recognition
setSize	57
pANOVA	5.73e-14
s.dist	-0.575
p.adjustANOVA	3.09e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
EIF3E	-5343
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
EIF4B	-5262
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
EIF4A2	-5219
FAU	-5214
RPS16	-5154
EIF3H	-5057

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
EIF3E	-5343
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
EIF4B	-5262
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
EIF4A2	-5219
FAU	-5214
RPS16	-5154
EIF3H	-5057
EIF4A1	-5053
EIF3G	-5021
RPS29	-5016
EIF3K	-4970
RPS3	-4880
EIF3L	-4845
EIF3A	-4833
EIF2S3	-4783
RPS28	-4714
EIF3F	-4665
RPS27	-4582
RPS7	-4508
RPS10	-4485
EIF3D	-4410
EIF5	-4379
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPS6	-3879
RPS27A	-3866
EIF3M	-3823
RPS26	-3459
RPS2	-3043
EIF3J	-623
EIF3B	-494
EIF4E	-295
EIF2S1	314
RPS17	512
EIF4G1	767
EIF3I	772
EIF4H	1327
RPS20	1429
EIF1AX	5020
EIF2S2	5025
RPSA	5189
RPS27L	5275
RPS19	5283

---

Selenoamino acid metabolism

Selenoamino acid metabolism

	1005
set	Selenoamino acid metabolism
setSize	101
pANOVA	1.38e-22
s.dist	-0.563
p.adjustANOVA	1.27e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
RPL4	-4965
RPL36A	-4904
RPS3	-4880
PAPSS1	-4867
RPL23A	-4860
TXNRD1	-4829
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
RPS26	-3459
RPS2	-3043
GSR	-3018
AIMP1	-477
AHCY	-351
HNMT	208
RPL27	315
RPS17	512
PSTK	795
SEPSECS	1381
RPS20	1429
AIMP2	2065
SCLY	2077
EEFSEC	2109
PAPSS2	2338
RPL35	2495
RPL9	3470
RPL39L	3526
SECISBP2	3873
RPL26L1	4044
SEPHS2	4531
CTH	4794
RPSA	5189
EEF1E1	5202
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Chaperone Mediated Autophagy

Chaperone Mediated Autophagy

	156
set	Chaperone Mediated Autophagy
setSize	18
pANOVA	4.23e-05
s.dist	-0.558
p.adjustANOVA	0.000856

Top enriched genes

Top 20 genes

GeneID	Gene Rank
VIM	-5414
UBA52	-5283
HSP90AB1	-5163
HSP90AA1	-5118
LAMP2	-5086
EEF1A1	-5006
RNASE1	-4975
HSPA8	-4932
UBC	-4654
PLIN2	-4588
RPS27A	-3866
HDAC6	-2863
UBB	-2219
PLIN3	-2036
PCNT	-1265
IFT88	1095
ARL13B	1815
PARK7	4778

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
VIM	-5414
UBA52	-5283
HSP90AB1	-5163
HSP90AA1	-5118
LAMP2	-5086
EEF1A1	-5006
RNASE1	-4975
HSPA8	-4932
UBC	-4654
PLIN2	-4588
RPS27A	-3866
HDAC6	-2863
UBB	-2219
PLIN3	-2036
PCNT	-1265
IFT88	1095
ARL13B	1815
PARK7	4778

---

mRNA decay by 3’ to 5’ exoribonuclease

mRNA decay by 3’ to 5’ exoribonuclease

	1273
set	mRNA decay by 3’ to 5’ exoribonuclease
setSize	13
pANOVA	0.000514
s.dist	0.556
p.adjustANOVA	0.00646

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NT5C3B	5107
EXOSC8	4705
EXOSC1	4199
EXOSC5	3992
EXOSC9	3483
EXOSC6	3298
EXOSC4	3131
DCPS	3032
EXOSC7	2652
EXOSC3	1999
EXOSC2	1678
HBS1L	1122
DIS3	-505

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NT5C3B	5107
EXOSC8	4705
EXOSC1	4199
EXOSC5	3992
EXOSC9	3483
EXOSC6	3298
EXOSC4	3131
DCPS	3032
EXOSC7	2652
EXOSC3	1999
EXOSC2	1678
HBS1L	1122
DIS3	-505

---

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

	44
set	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize	58
pANOVA	3.48e-13
s.dist	-0.552
p.adjustANOVA	1.61e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
EIF3E	-5343
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
EIF4B	-5262
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
EIF4A2	-5219
FAU	-5214
RPS16	-5154
EIF3H	-5057

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
EIF3E	-5343
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
EIF4B	-5262
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
EIF4A2	-5219
FAU	-5214
RPS16	-5154
EIF3H	-5057
EIF4A1	-5053
EIF3G	-5021
RPS29	-5016
PABPC1	-4976
EIF3K	-4970
RPS3	-4880
EIF3L	-4845
EIF3A	-4833
EIF2S3	-4783
RPS28	-4714
EIF3F	-4665
RPS27	-4582
RPS7	-4508
RPS10	-4485
EIF3D	-4410
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPS6	-3879
RPS27A	-3866
EIF3M	-3823
RPS26	-3459
RPS2	-3043
EIF3J	-623
EIF3B	-494
EIF4E	-295
EIF2S1	314
RPS17	512
EIF4G1	767
EIF3I	772
EIF4H	1327
RPS20	1429
EIF4EBP1	4631
EIF1AX	5020
EIF2S2	5025
RPSA	5189
RPS27L	5275
RPS19	5283

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

	686
set	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize	113
pANOVA	2.16e-22
s.dist	-0.53
p.adjustANOVA	1.75e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
PABPC1	-4976
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
EIF4A3	-4592
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
PNRC2	-4419
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
UPF2	-3590
RPS26	-3459
RPS2	-3043
MAGOH	-2540
PPP2R2A	-2212
SMG8	-2134
DCP1A	-1828
RNPS1	-1748
UPF3A	-1597
SMG1	-1532
SMG6	-861
UPF1	-311
SMG7	-237
RPL27	315
RPS17	512
NCBP2	598
EIF4G1	767
NCBP1	1114
UPF3B	1156
RPS20	1429
RBM8A	1893
SMG9	1995
GSPT2	2028
PPP2R1A	2360
CASC3	2396
PPP2CA	2421
RPL35	2495
SMG5	3072
RPL9	3470
RPL39L	3526
GSPT1	3600
RPL26L1	4044
MAGOHB	4049
ETF1	4449
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)

	688
set	Nonsense-Mediated Decay (NMD)
setSize	113
pANOVA	2.16e-22
s.dist	-0.53
p.adjustANOVA	1.75e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
PABPC1	-4976
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
EIF4A3	-4592
RPS27	-4582
RPS7	-4508
RPL15	-4489
RPS10	-4485
PNRC2	-4419
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
UPF2	-3590
RPS26	-3459
RPS2	-3043
MAGOH	-2540
PPP2R2A	-2212
SMG8	-2134
DCP1A	-1828
RNPS1	-1748
UPF3A	-1597
SMG1	-1532
SMG6	-861
UPF1	-311
SMG7	-237
RPL27	315
RPS17	512
NCBP2	598
EIF4G1	767
NCBP1	1114
UPF3B	1156
RPS20	1429
RBM8A	1893
SMG9	1995
GSPT2	2028
PPP2R1A	2360
CASC3	2396
PPP2CA	2421
RPL35	2495
SMG5	3072
RPL9	3470
RPL39L	3526
GSPT1	3600
RPL26L1	4044
MAGOHB	4049
ETF1	4449
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

APOBEC3G mediated resistance to HIV-1 infection

APOBEC3G mediated resistance to HIV-1 infection

	18
set	APOBEC3G mediated resistance to HIV-1 infection
setSize	10
pANOVA	0.00467
s.dist	0.517
p.adjustANOVA	0.0351

Top enriched genes

Top 20 genes

GeneID	Gene Rank
gag	5290
vif	5290
vpu	5290
vpr	5285
rev	5242
HMGA1	5001
APOBEC3G	2041
PSIP1	1245
BANF1	-2562
PPIA	-5088

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
gag	5290
vif	5290
vpu	5290
vpr	5285
rev	5242
HMGA1	5001
APOBEC3G	2041
PSIP1	1245
BANF1	-2562
PPIA	-5088

---

Negative regulation of FLT3

Negative regulation of FLT3

	666
set	Negative regulation of FLT3
setSize	11
pANOVA	0.00355
s.dist	-0.508
p.adjustANOVA	0.0299

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-5283
UBC	-4654
CBL	-4455
PTPRJ	-4344
CSK	-4187
RPS27A	-3866
SOCS6	-2479
UBB	-2219
SH2B3	-1746
ABL2	178
SLA	2488

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-5283
UBC	-4654
CBL	-4455
PTPRJ	-4344
CSK	-4187
RPS27A	-3866
SOCS6	-2479
UBB	-2219
SH2B3	-1746
ABL2	178
SLA	2488

---

Mitochondrial RNA degradation

Mitochondrial RNA degradation

	609
set	Mitochondrial RNA degradation
setSize	23
pANOVA	3.01e-05
s.dist	-0.503
p.adjustANOVA	0.000629

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-CO2	-5354
MT-CO1	-5257
MT-ND4L	-5230
MT-ND3	-5198
MT-ND4	-5124
MT-CYB	-5047
MT-ND5	-5014
MT-ND2	-4983
MT-CO3	-4913
MT-ATP6	-4607
MT-ND6	-4575
GRSF1	-4387
MT-ATP8	-3734
MT-ND1	-3630
PNPT1	-3569
SLIRP	-2966
LRPPRC	-2898
TBRG4	-2161
FASTKD5	-889
FASTK	2573

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-CO2	-5354
MT-CO1	-5257
MT-ND4L	-5230
MT-ND3	-5198
MT-ND4	-5124
MT-CYB	-5047
MT-ND5	-5014
MT-ND2	-4983
MT-CO3	-4913
MT-ATP6	-4607
MT-ND6	-4575
GRSF1	-4387
MT-ATP8	-3734
MT-ND1	-3630
PNPT1	-3569
SLIRP	-2966
LRPPRC	-2898
TBRG4	-2161
FASTKD5	-889
FASTK	2573
FASTKD2	4046
REXO2	4511
SUPV3L1	5179

---

NOTCH2 Activation and Transmission of Signal to the Nucleus

NOTCH2 Activation and Transmission of Signal to the Nucleus

	648
set	NOTCH2 Activation and Transmission of Signal to the Nucleus
setSize	16
pANOVA	0.000663
s.dist	-0.492
p.adjustANOVA	0.0081

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-5283
ADAM10	-4911
NOTCH2	-4839
UBC	-4654
MDK	-4166
RPS27A	-3866
NCSTN	-3805
APH1A	-3520
JAG1	-3186
MIB1	-2985
PSEN2	-2882
UBB	-2219
PSEN1	-927
PSENEN	-189
APH1B	698
MIB2	3665

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-5283
ADAM10	-4911
NOTCH2	-4839
UBC	-4654
MDK	-4166
RPS27A	-3866
NCSTN	-3805
APH1A	-3520
JAG1	-3186
MIB1	-2985
PSEN2	-2882
UBB	-2219
PSEN1	-927
PSENEN	-189
APH1B	698
MIB2	3665

---

Negative regulation of MET activity

Negative regulation of MET activity

	668
set	Negative regulation of MET activity
setSize	16
pANOVA	0.001
s.dist	-0.475
p.adjustANOVA	0.0113

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-5283
UBC	-4654
EPS15	-4554
CBL	-4455
PTPRJ	-4344
RPS27A	-3866
USP8	-3252
STAM2	-3090
HGS	-2721
PTPN2	-2228
UBB	-2219
SH3GL1	-1786
PTPN1	-1490
GRB2	147
SH3KBP1	268
STAM	1871

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-5283
UBC	-4654
EPS15	-4554
CBL	-4455
PTPRJ	-4344
RPS27A	-3866
USP8	-3252
STAM2	-3090
HGS	-2721
PTPN2	-2228
UBB	-2219
SH3GL1	-1786
PTPN1	-1490
GRB2	147
SH3KBP1	268
STAM	1871

---

Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication

	485
set	Influenza Viral RNA Transcription and Replication
setSize	133
pANOVA	3.53e-21
s.dist	-0.475
p.adjustANOVA	2.54e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
POLR2L	-5182
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
HSP90AA1	-5118
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
RPL4	-4965
RPL36A	-4904
RPS3	-4880
RPL23A	-4860
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
RPS27	-4582
PARP1	-4546
POLR2A	-4519
RPS7	-4508
RPL15	-4489
RPS10	-4485
GRSF1	-4387
RPL8	-4361
RPS4Y1	-4333
RPS12	-4284
RANBP2	-4226
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
RPS26	-3459
NUP155	-3366
TPR	-3292
NUP37	-3268
NUP188	-3095
NUP58	-3094
RPS2	-3043
NUP50	-2920
POLR2E	-2726
SEH1L	-2629
NUP133	-2626
POLR2I	-2001
GTF2F1	-1484
NUP85	-1460
NUP160	-1355
NDC1	-1286
POLR2B	-1063
NUP93	-1043
POLR2G	-999
RAE1	-963
NUP153	-880
GTF2F2	-850
NUP42	-486
NUP98	-80
DNAJC3	29
NUP214	234
RPL27	315
RPS17	512
NUP107	1062
RPS20	1429
NUP43	1697
NUP62	1966
POLR2K	1974
NUP205	2280
AAAS	2293
POLR2C	2420
RPL35	2495
NUP54	2728
POLR2D	2800
SEC13	2856
POLR2F	2993
POLR2H	3325
POLR2J	3350
IPO5	3392
RPL9	3470
NUP88	3481
RPL39L	3526
NUP210	3759
POM121	3797
RPL26L1	4044
POM121C	4099
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

HDMs demethylate histones

HDMs demethylate histones

	436
set	HDMs demethylate histones
setSize	21
pANOVA	0.000171
s.dist	-0.474
p.adjustANOVA	0.00258

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KDM5B	-5225
ARID5B	-5020
KDM5A	-4613
JMJD6	-3786
KDM7A	-3760
KDM5C	-3647
KDM2A	-3545
PHF2	-3388
KDM4B	-3273
UTY	-3038
KDM4C	-2989
KDM1B	-2165
PHF8	-2100
KDM1A	-2042
KDM3A	-1941
KDM5D	-1381
KDM4A	-1032
KDM6B	-902
KDM3B	-470
KDM2B	-95

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KDM5B	-5225
ARID5B	-5020
KDM5A	-4613
JMJD6	-3786
KDM7A	-3760
KDM5C	-3647
KDM2A	-3545
PHF2	-3388
KDM4B	-3273
UTY	-3038
KDM4C	-2989
KDM1B	-2165
PHF8	-2100
KDM1A	-2042
KDM3A	-1941
KDM5D	-1381
KDM4A	-1032
KDM6B	-902
KDM3B	-470
KDM2B	-95
KDM6A	-84

---

PD-1 signaling

PD-1 signaling

	719
set	PD-1 signaling
setSize	14
pANOVA	0.00234
s.dist	-0.47
p.adjustANOVA	0.0213

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD4	-5320
HLA-DRB1	-5206
HLA-DPA1	-5176
HLA-DPB1	-5122
HLA-DRA	-5064
PTPN6	-5015
CSK	-4187
HLA-DRB5	-2598
HLA-DQA2	-2564
PDCD1LG2	-1345
HLA-DQA1	-1299
HLA-DQB1	-900
PTPN11	2747
CD274	4987

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD4	-5320
HLA-DRB1	-5206
HLA-DPA1	-5176
HLA-DPB1	-5122
HLA-DRA	-5064
PTPN6	-5015
CSK	-4187
HLA-DRB5	-2598
HLA-DQA2	-2564
PDCD1LG2	-1345
HLA-DQA1	-1299
HLA-DQB1	-900
PTPN11	2747
CD274	4987

---

Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of cytoskeletal proteins

	136
set	Caspase-mediated cleavage of cytoskeletal proteins
setSize	10
pANOVA	0.0103
s.dist	-0.468
p.adjustANOVA	0.0599

Top enriched genes

Top 20 genes

GeneID	Gene Rank
VIM	-5414
SPTAN1	-5247
GSN	-4951
PLEC	-4509
CASP3	-4325
CASP8	-3651
ADD1	-1892
DBNL	382
CASP6	1253
CASP7	2667

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
VIM	-5414
SPTAN1	-5247
GSN	-4951
PLEC	-4509
CASP3	-4325
CASP8	-3651
ADD1	-1892
DBNL	382
CASP6	1253
CASP7	2667

---

Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

	314
set	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
setSize	11
pANOVA	0.00722
s.dist	-0.468
p.adjustANOVA	0.0484

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IRS2	-4946
PIK3CG	-4638
PIK3CB	-4328
PIK3CD	-4300
JAK2	-3244
PIK3R5	-3002
PIK3CA	-2266
GAB1	-1907
PIK3R1	-1328
EPOR	726
LYN	1010

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IRS2	-4946
PIK3CG	-4638
PIK3CB	-4328
PIK3CD	-4300
JAK2	-3244
PIK3R5	-3002
PIK3CA	-2266
GAB1	-1907
PIK3R1	-1328
EPOR	726
LYN	1010

---

Complement cascade

Complement cascade

	182
set	Complement cascade
setSize	18
pANOVA	0.000627
s.dist	-0.466
p.adjustANOVA	0.0078

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CFD	-5398
CLU	-5290
FCN1	-4997
CD81	-4816
CD59	-4514
PROS1	-4429
C1QC	-4362
CR1	-4168
C5AR1	-3947
C2	-3584
CD46	-3558
SERPING1	-3346
C1QA	-2751
C1QB	-1139
C3AR1	-1103
C9	1652
C3	4675
CD55	5133

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CFD	-5398
CLU	-5290
FCN1	-4997
CD81	-4816
CD59	-4514
PROS1	-4429
C1QC	-4362
CR1	-4168
C5AR1	-3947
C2	-3584
CD46	-3558
SERPING1	-3346
C1QA	-2751
C1QB	-1139
C3AR1	-1103
C9	1652
C3	4675
CD55	5133

---

Z-decay: degradation of maternal mRNAs by zygotically expressed factors

Z-decay: degradation of maternal mRNAs by zygotically expressed factors

	1262
set	Z-decay: degradation of maternal mRNAs by zygotically expressed factors
setSize	10
pANOVA	0.0112
s.dist	-0.463
p.adjustANOVA	0.0631

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF4B	-5262
EIF4A2	-5219
EIF4A1	-5053
PABPC1	-4976
EIF4A3	-4592
PABPN1	-4365
EIF4E	-295
EIF4G1	767
DIS3L2	1140
PAIP1	2443

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF4B	-5262
EIF4A2	-5219
EIF4A1	-5053
PABPC1	-4976
EIF4A3	-4592
PABPN1	-4365
EIF4E	-295
EIF4G1	767
DIS3L2	1140
PAIP1	2443

---

InlB-mediated entry of Listeria monocytogenes into host cell

InlB-mediated entry of Listeria monocytogenes into host cell

	491
set	InlB-mediated entry of Listeria monocytogenes into host cell
setSize	12
pANOVA	0.0057
s.dist	-0.461
p.adjustANOVA	0.0406

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-5283
UBC	-4654
EPS15	-4554
CBL	-4455
RPS27A	-3866
STAM2	-3090
HGS	-2721
UBB	-2219
SH3GL1	-1786
GRB2	147
SH3KBP1	268
STAM	1871

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-5283
UBC	-4654
EPS15	-4554
CBL	-4455
RPS27A	-3866
STAM2	-3090
HGS	-2721
UBB	-2219
SH3GL1	-1786
GRB2	147
SH3KBP1	268
STAM	1871

---

TICAM1,TRAF6-dependent induction of TAK1 complex

TICAM1,TRAF6-dependent induction of TAK1 complex

	1140
set	TICAM1,TRAF6-dependent induction of TAK1 complex
setSize	10
pANOVA	0.0117
s.dist	-0.46
p.adjustANOVA	0.0653

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-5283
UBC	-4654
TAB2	-4142
RPS27A	-3866
UBB	-2219
TAB1	-2061
MAP3K7	-1774
TAB3	-1459
TICAM1	-945
TRAF6	1154

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-5283
UBC	-4654
TAB2	-4142
RPS27A	-3866
UBB	-2219
TAB1	-2061
MAP3K7	-1774
TAB3	-1459
TICAM1	-945
TRAF6	1154

---

Signaling by NOTCH2

Signaling by NOTCH2

	1070
set	Signaling by NOTCH2
setSize	24
pANOVA	0.000127
s.dist	-0.452
p.adjustANOVA	0.00198

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBA52	-5283
ADAM10	-4911
NOTCH2	-4839
RBPJ	-4773
UBC	-4654
EP300	-4219
MDK	-4166
RPS27A	-3866
MAML2	-3843
MAML1	-3806
NCSTN	-3805
APH1A	-3520
JAG1	-3186
MAMLD1	-3140
MIB1	-2985
PSEN2	-2882
UBB	-2219
CREB1	-1363
PSEN1	-927
MAML3	-530

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBA52	-5283
ADAM10	-4911
NOTCH2	-4839
RBPJ	-4773
UBC	-4654
EP300	-4219
MDK	-4166
RPS27A	-3866
MAML2	-3843
MAML1	-3806
NCSTN	-3805
APH1A	-3520
JAG1	-3186
MAMLD1	-3140
MIB1	-2985
PSEN2	-2882
UBB	-2219
CREB1	-1363
PSEN1	-927
MAML3	-530
PSENEN	-189
APH1B	698
MIB2	3665
HES1	5279

---

Influenza Infection

Influenza Infection

	484
set	Influenza Infection
setSize	152
pANOVA	2.69e-21
s.dist	-0.446
p.adjustANOVA	2.05e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPL10A	-5412
RPL34	-5410
RPL3	-5408
RPL7A	-5406
RPL10	-5405
RPL26	-5404
RPL32	-5400
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPL12	-5388
RPS24	-5383
RPL11	-5379
RPL28	-5371
RPL22	-5369
RPL30	-5361
RPL7	-5358
RPL36AL	-5344
RPL37	-5338
RPL14	-5336
RPL5	-5330
RPL35A	-5312
RPL29	-5301
RPS18	-5284
UBA52	-5283
RPS11	-5282
RPL41	-5279
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
RPL6	-5222
RPL22L1	-5218
RPL24	-5215
FAU	-5214
RPL18	-5196
POLR2L	-5182
RPL23	-5177
RPLP2	-5158
RPS16	-5154
RPL21	-5134
RPL27A	-5129
RPL38	-5123
HSP90AA1	-5118
CLTA	-5116
RPL37A	-5099
RPL39	-5067
RPL17	-5043
RPS29	-5016
RPL19	-5013
RPL4	-4965
RPL36A	-4904
RPS3	-4880
CANX	-4861
RPL23A	-4860
RPL31	-4801
RPL13A	-4747
RPS28	-4714
RPL36	-4705
RPL13	-4667
RPS27	-4582
PARP1	-4546
POLR2A	-4519
RPS7	-4508
RPL15	-4489
RPS10	-4485
CALR	-4435
GRSF1	-4387
PABPN1	-4365
RPL8	-4361
SLC25A6	-4339
RPS4Y1	-4333
RPS12	-4284
HSPA1A	-4248
CLTC	-4234
RANBP2	-4226
RPS5	-4093
RPL18A	-4001
RPS6	-3879
RPS27A	-3866
RPS26	-3459
NUP155	-3366
TPR	-3292
NUP37	-3268
NUP188	-3095
NUP58	-3094
RPS2	-3043
NUP50	-2920
POLR2E	-2726
SEH1L	-2629
NUP133	-2626
KPNA4	-2180
POLR2I	-2001
KPNA5	-1902
GTF2F1	-1484
NUP85	-1460
NUP160	-1355
NDC1	-1286
POLR2B	-1063
NUP93	-1043
POLR2G	-999
RAE1	-963
NUP153	-880
GTF2F2	-850
KPNA2	-828
KPNB1	-753
NUP42	-486
XPO1	-326
NUP98	-80
DNAJC3	29
NUP214	234
RAN	257
RPL27	315
RPS17	512
KPNA1	687
TGFB1	701
NUP107	1062
CPSF4	1078
RPS20	1429
NUP43	1697
NUP62	1966
POLR2K	1974
NUP205	2280
AAAS	2293
POLR2C	2420
RPL35	2495
EIF2AK2	2659
NUP54	2728
POLR2D	2800
SEC13	2856
POLR2F	2993
POLR2H	3325
POLR2J	3350
KPNA3	3368
IPO5	3392
RPL9	3470
NUP88	3481
RPL39L	3526
NUP210	3759
POM121	3797
ISG15	3842
RPL26L1	4044
POM121C	4099
RPSA	5189
RPLP1	5252
RPLP0	5270
RPS27L	5275
RPS19	5283

---

NGF-stimulated transcription

NGF-stimulated transcription

	644
set	NGF-stimulated transcription
setSize	25
pANOVA	0.000124
s.dist	-0.444
p.adjustANOVA	0.00196

Top enriched genes

Top 20 genes

GeneID	Gene Rank
JUNB	-5396
SGK1	-5249
JUND	-5221
ID2	-5183
EGR2	-5181
CHD4	-4707
FOS	-4662
TRIB1	-4614
ID3	-4257
EP300	-4219
REST	-3856
MEF2D	-3848
SRF	-3040
NAB2	-3029
NAB1	-2140
CDK5	-1668
F3	-1622
CREB1	-1363
ATF1	-340
TCF12	-259

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
JUNB	-5396
SGK1	-5249
JUND	-5221
ID2	-5183
EGR2	-5181
CHD4	-4707
FOS	-4662
TRIB1	-4614
ID3	-4257
EP300	-4219
REST	-3856
MEF2D	-3848
SRF	-3040
NAB2	-3029
NAB1	-2140
CDK5	-1668
F3	-1622
CREB1	-1363
ATF1	-340
TCF12	-259
ATF2	-140
DNM2	-18
LYL1	581
ELK1	4206
FOSL1	4416

---

SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery

	976
set	SARS-CoV-2 modulates host translation machinery
setSize	47
pANOVA	1.55e-07
s.dist	-0.443
p.adjustANOVA	4.28e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
FAU	-5214
RPS16	-5154
RPS29	-5016
RPS3	-4880
RPS28	-4714
RPS27	-4582

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS9	-5418
RPS15	-5399
RPS13	-5395
RPS14	-5394
RPS8	-5392
RPS23	-5391
RPS24	-5383
RPS18	-5284
RPS11	-5282
RPS15A	-5278
RPS21	-5276
RPS25	-5259
RPS4X	-5243
RPS3A	-5236
FAU	-5214
RPS16	-5154
RPS29	-5016
RPS3	-4880
RPS28	-4714
RPS27	-4582
RPS7	-4508
RPS10	-4485
RPS4Y1	-4333
RPS12	-4284
RPS5	-4093
SNRPE	-3921
RPS6	-3879
RPS27A	-3866
RPS26	-3459
RPS2	-3043
GEMIN8	-2112
SNRPB	179
SNRPG	220
SNRPD1	270
SNRPD2	434
SNRPF	497
RPS17	512
GEMIN5	666
DDX20	944
RPS20	1429
GEMIN6	1602
GEMIN7	2816
SNRPD3	3313
GEMIN2	3706
RPSA	5189
RPS27L	5275
RPS19	5283

---

Other semaphorin interactions

Other semaphorin interactions

	713
set	Other semaphorin interactions
setSize	11
pANOVA	0.0113
s.dist	-0.441
p.adjustANOVA	0.0634

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TREM2	-5349
PTPRC	-5331
TYROBP	-5231
PLXND1	-5208
PLXNC1	-5073
CD72	-4956
SEMA4A	-2786
SEMA7A	-1575
ITGB1	476
PLXNA1	3692
PLXNA2	4695

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TREM2	-5349
PTPRC	-5331
TYROBP	-5231
PLXND1	-5208
PLXNC1	-5073
CD72	-4956
SEMA4A	-2786
SEMA7A	-1575
ITGB1	476
PLXNA1	3692
PLXNA2	4695

---

Antimicrobial peptides

Antimicrobial peptides

	63
set	Antimicrobial peptides
setSize	15
pANOVA	0.00377
s.dist	-0.432
p.adjustANOVA	0.0306

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LYZ	-5389
RNASE6	-5385
CD4	-5320
CLU	-5290
S100A8	-5272
TLR1	-5108
BPI	-4788
S100A9	-4738
ATP7A	-3269
SLC11A1	-3203
TLR2	-389
CAMP	1059
ATOX1	1193
PDZD11	5013
env	5290

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LYZ	-5389
RNASE6	-5385
CD4	-5320
CLU	-5290
S100A8	-5272
TLR1	-5108
BPI	-4788
S100A9	-4738
ATP7A	-3269
SLC11A1	-3203
TLR2	-389
CAMP	1059
ATOX1	1193
PDZD11	5013
env	5290

---

Gap junction trafficking

Gap junction trafficking

	398
set	Gap junction trafficking
setSize	18
pANOVA	0.00159
s.dist	-0.43
p.adjustANOVA	0.0164

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACTG1	-5258
CLTA	-5116
TUBA1A	-5032
ACTB	-4703
DAB2	-4574
TUBA1B	-4448
TUBB3	-4371
CLTC	-4234
TUBB4B	-3961
TUBB2A	-3146
TUBA1C	-3001
TUBB4A	-2837
MYO6	-1057
TUBB6	-800
DNM2	-18
TUBA4A	494
CLTB	4464
AP2M1	5095

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACTG1	-5258
CLTA	-5116
TUBA1A	-5032
ACTB	-4703
DAB2	-4574
TUBA1B	-4448
TUBB3	-4371
CLTC	-4234
TUBB4B	-3961
TUBB2A	-3146
TUBA1C	-3001
TUBB4A	-2837
MYO6	-1057
TUBB6	-800
DNM2	-18
TUBA4A	494
CLTB	4464
AP2M1	5095

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] stringr_1.5.0        harmony_0.1.1        Rcpp_1.0.11         
##  [4] tidyr_1.3.0          SeuratWrappers_0.3.1 SeuratObject_4.1.3  
##  [7] Seurat_4.3.0.1       pkgload_1.3.2.1      GGally_2.1.2        
## [10] ggplot2_3.4.3        reshape2_1.4.4       beeswarm_0.4.0      
## [13] gtools_3.9.4         tibble_3.2.1         dplyr_1.1.3         
## [16] echarts4r_0.4.5      kableExtra_1.3.4     gplots_3.1.3        
## [19] mitch_1.12.0        
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3     rstudioapi_0.15.0      jsonlite_1.8.7        
##   [4] magrittr_2.0.3         spatstat.utils_3.0-3   farver_2.1.1          
##   [7] rmarkdown_2.25         vctrs_0.6.3            ROCR_1.0-11           
##  [10] spatstat.explore_3.2-3 webshot_0.5.5          htmltools_0.5.6       
##  [13] sass_0.4.7             sctransform_0.3.5      parallelly_1.36.0     
##  [16] KernSmooth_2.23-22     bslib_0.5.1            htmlwidgets_1.6.2     
##  [19] ica_1.0-3              plyr_1.8.8             plotly_4.10.2         
##  [22] zoo_1.8-12             cachem_1.0.8           igraph_1.5.1          
##  [25] mime_0.12              lifecycle_1.0.3        pkgconfig_2.0.3       
##  [28] rsvd_1.0.5             Matrix_1.6-1.1         R6_2.5.1              
##  [31] fastmap_1.1.1          fitdistrplus_1.1-11    future_1.33.0         
##  [34] shiny_1.7.5            digest_0.6.33          colorspace_2.1-0      
##  [37] reshape_0.8.9          patchwork_1.1.3        tensor_1.5            
##  [40] irlba_2.3.5.1          labeling_0.4.3         progressr_0.14.0      
##  [43] fansi_1.0.4            spatstat.sparse_3.0-2  httr_1.4.7            
##  [46] polyclip_1.10-4        abind_1.4-5            compiler_4.3.1        
##  [49] remotes_2.4.2.1        withr_2.5.0            highr_0.10            
##  [52] R.utils_2.12.2         MASS_7.3-60            caTools_1.18.2        
##  [55] tools_4.3.1            lmtest_0.9-40          httpuv_1.6.11         
##  [58] future.apply_1.11.0    goftest_1.2-3          R.oo_1.25.0           
##  [61] glue_1.6.2             nlme_3.1-163           promises_1.2.1        
##  [64] grid_4.3.1             Rtsne_0.16             cluster_2.1.4         
##  [67] generics_0.1.3         gtable_0.3.4           spatstat.data_3.0-1   
##  [70] R.methodsS3_1.8.2      data.table_1.14.8      sp_2.0-0              
##  [73] xml2_1.3.5             utf8_1.2.3             spatstat.geom_3.2-5   
##  [76] RcppAnnoy_0.0.21       ggrepel_0.9.3          RANN_2.6.1            
##  [79] pillar_1.9.0           later_1.3.1            splines_4.3.1         
##  [82] lattice_0.21-8         survival_3.5-7         deldir_1.0-9          
##  [85] tidyselect_1.2.0       miniUI_0.1.1.1         pbapply_1.7-2         
##  [88] knitr_1.44             gridExtra_2.3          svglite_2.1.1         
##  [91] scattermore_1.2        xfun_0.40              matrixStats_1.0.0     
##  [94] stringi_1.7.12         lazyeval_0.2.2         yaml_2.3.7            
##  [97] evaluate_0.21          codetools_0.2-19       BiocManager_1.30.22   
## [100] cli_3.6.1              uwot_0.1.16            xtable_1.8-4          
## [103] reticulate_1.32.0      systemfonts_1.0.4      munsell_0.5.0         
## [106] jquerylib_0.1.4        globals_0.16.2         spatstat.random_3.1-6 
## [109] png_0.1-8              parallel_4.3.1         ellipsis_0.3.2        
## [112] bitops_1.0-7           listenv_0.9.0          viridisLite_0.4.2     
## [115] scales_1.2.1           ggridges_0.5.4         leiden_0.4.3          
## [118] purrr_1.0.2            rlang_1.1.1            cowplot_1.1.1         
## [121] rvest_1.0.3

END of report