date generated: 2022-06-16

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##           estill  novakovic
## A1BG  -4.2144199 -1.1785651
## A1CF   0.0000000 -1.3479872
## A2BP1 -0.8119538 -3.0345235
## A2LD1 -0.6649262  0.3728102
## A2M    0.1340821 -1.1788808
## A2ML1  2.1730273 -1.0983477

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 19942
duplicated_genes_present 0
num_profile_genes_in_sets 9644
num_profile_genes_not_in_sets 10298
profile_pearson_correl 0.30436
profile_spearman_correl 0.35025

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2546
num_genesets_excluded 1028
num_genesets_included 1518

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 546

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.estill s.novakovic p.estill p.novakovic
Expression and translocation of olfactory receptors 308 0.00e+00 0.00e+00 0.895 0.666 0.5970 9.86e-91 4.26e-73
Olfactory Signaling Pathway 315 0.00e+00 0.00e+00 0.865 0.646 0.5750 2.95e-87 2.28e-69
Beta defensins 28 8.15e-11 3.34e-09 0.860 0.549 0.6630 4.97e-07 1.28e-09
Defensins 36 7.16e-13 4.18e-11 0.832 0.529 0.6430 4.01e-08 2.44e-11
RUNX3 regulates p14-ARF 10 8.38e-04 5.03e-03 0.798 -0.588 -0.5390 1.28e-03 3.15e-03
Transcriptional regulation of testis differentiation 12 2.07e-04 1.66e-03 0.789 -0.631 -0.4740 1.53e-04 4.48e-03
FOXO-mediated transcription of cell cycle genes 15 1.90e-05 2.42e-04 0.783 -0.402 -0.6720 7.00e-03 6.56e-06
Endosomal/Vacuolar pathway 10 1.42e-03 7.54e-03 0.766 -0.581 -0.4990 1.46e-03 6.31e-03
Disorders of Developmental Biology 11 1.14e-03 6.32e-03 0.744 -0.506 -0.5460 3.66e-03 1.72e-03
Disorders of Nervous System Development 11 1.14e-03 6.32e-03 0.744 -0.506 -0.5460 3.66e-03 1.72e-03
Loss of function of MECP2 in Rett syndrome 11 1.14e-03 6.32e-03 0.744 -0.506 -0.5460 3.66e-03 1.72e-03
Pervasive developmental disorders 11 1.14e-03 6.32e-03 0.744 -0.506 -0.5460 3.66e-03 1.72e-03
eNOS activation 11 5.87e-04 3.88e-03 0.730 -0.669 -0.2930 1.23e-04 9.21e-02
mRNA Editing 10 4.07e-03 1.67e-02 0.703 0.517 0.4770 4.61e-03 9.06e-03
Antimicrobial peptides 69 1.04e-17 8.33e-16 0.699 0.383 0.5850 3.76e-08 4.10e-17
Repression of WNT target genes 13 3.67e-04 2.64e-03 0.677 -0.230 -0.6370 1.51e-01 6.98e-05
Defective B4GALT7 causes EDS, progeroid type 17 8.16e-05 8.20e-04 0.675 -0.597 -0.3140 2.00e-05 2.50e-02
Defective B3GAT3 causes JDSSDHD 17 8.40e-05 8.30e-04 0.672 -0.598 -0.3080 1.98e-05 2.81e-02
Crosslinking of collagen fibrils 10 4.51e-03 1.80e-02 0.660 -0.288 -0.5940 1.14e-01 1.14e-03
Interaction With Cumulus Cells And The Zona Pellucida 11 4.89e-03 1.91e-02 0.654 0.517 0.4010 2.98e-03 2.13e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 12 3.59e-03 1.50e-02 0.648 -0.423 -0.4910 1.13e-02 3.20e-03
Defective EXT2 causes exostoses 2 12 3.59e-03 1.50e-02 0.648 -0.423 -0.4910 1.13e-02 3.20e-03
Glucuronidation 19 1.31e-04 1.17e-03 0.646 0.509 0.3980 1.23e-04 2.69e-03
Metabolism of nitric oxide: NOS3 activation and regulation 15 4.01e-04 2.85e-03 0.633 -0.589 -0.2310 7.79e-05 1.21e-01
HS-GAG degradation 18 3.15e-04 2.34e-03 0.622 -0.518 -0.3450 1.42e-04 1.12e-02
Keratinization 197 1.30e-36 3.96e-34 0.615 0.408 0.4610 5.51e-23 6.53e-29
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 4.53e-04 3.11e-03 0.609 -0.541 -0.2810 1.13e-04 4.48e-02
Translocation of ZAP-70 to Immunological synapse 17 7.63e-04 4.69e-03 0.605 0.500 0.3410 3.53e-04 1.50e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 4.33e-03 1.75e-02 0.598 -0.171 -0.5740 3.27e-01 9.87e-04
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 4.31e-03 1.75e-02 0.587 -0.361 -0.4630 1.93e-02 2.70e-03
Aspirin ADME 36 1.54e-06 2.54e-05 0.576 0.442 0.3710 4.51e-06 1.19e-04
Phosphorylation of CD3 and TCR zeta chains 20 4.39e-04 3.06e-03 0.576 0.486 0.3090 1.70e-04 1.67e-02
Beta-catenin phosphorylation cascade 16 2.53e-03 1.16e-02 0.573 -0.337 -0.4630 1.96e-02 1.34e-03
Butyrophilin (BTN) family interactions 12 7.03e-03 2.51e-02 0.571 0.522 0.2320 1.73e-03 1.65e-01
RUNX2 regulates bone development 29 3.00e-05 3.48e-04 0.567 -0.367 -0.4320 6.22e-04 5.66e-05
Chemokine receptors bind chemokines 52 8.82e-09 2.73e-07 0.566 0.378 0.4220 2.47e-06 1.41e-07
Acetylcholine Neurotransmitter Release Cycle 16 3.28e-03 1.39e-02 0.564 -0.440 -0.3520 2.30e-03 1.47e-02
Hormone ligand-binding receptors 12 2.60e-03 1.18e-02 0.561 0.558 0.0638 8.21e-04 7.02e-01
RUNX2 regulates osteoblast differentiation 22 4.73e-04 3.22e-03 0.559 -0.371 -0.4180 2.59e-03 6.90e-04
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 15 2.34e-03 1.10e-02 0.550 -0.519 -0.1840 5.01e-04 2.18e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 10 3.48e-02 7.83e-02 0.549 -0.367 -0.4090 4.47e-02 2.52e-02
Creation of C4 and C2 activators 14 8.06e-03 2.79e-02 0.549 0.319 0.4470 3.88e-02 3.79e-03
Formation of the cornified envelope 68 2.11e-10 8.20e-09 0.543 0.364 0.4030 2.05e-07 9.21e-09
Digestion 19 2.00e-03 9.88e-03 0.543 0.380 0.3880 4.13e-03 3.44e-03
A tetrasaccharide linker sequence is required for GAG synthesis 23 1.07e-04 9.77e-04 0.542 -0.515 -0.1700 1.92e-05 1.58e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 2.97e-02 7.04e-02 0.542 -0.472 -0.2650 9.67e-03 1.47e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 1.04e-02 3.33e-02 0.541 -0.403 -0.3610 9.02e-03 1.92e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 1.04e-02 3.33e-02 0.541 -0.403 -0.3610 9.02e-03 1.92e-02
Scavenging of heme from plasma 11 2.93e-02 6.97e-02 0.537 0.394 0.3650 2.37e-02 3.59e-02
Ethanol oxidation 11 2.32e-02 5.90e-02 0.537 0.271 0.4630 1.19e-01 7.79e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.estill s.novakovic p.estill p.novakovic
Expression and translocation of olfactory receptors 308 7.69e-120 1.17e-116 0.89500 0.666000 0.597000 9.86e-91 4.26e-73
Olfactory Signaling Pathway 315 1.67e-114 1.27e-111 0.86500 0.646000 0.575000 2.95e-87 2.28e-69
Beta defensins 28 8.15e-11 3.34e-09 0.86000 0.549000 0.663000 4.97e-07 1.28e-09
Defensins 36 7.16e-13 4.18e-11 0.83200 0.529000 0.643000 4.01e-08 2.44e-11
RUNX3 regulates p14-ARF 10 8.38e-04 5.03e-03 0.79800 -0.588000 -0.539000 1.28e-03 3.15e-03
Transcriptional regulation of testis differentiation 12 2.07e-04 1.66e-03 0.78900 -0.631000 -0.474000 1.53e-04 4.48e-03
FOXO-mediated transcription of cell cycle genes 15 1.90e-05 2.42e-04 0.78300 -0.402000 -0.672000 7.00e-03 6.56e-06
Endosomal/Vacuolar pathway 10 1.42e-03 7.54e-03 0.76600 -0.581000 -0.499000 1.46e-03 6.31e-03
Disorders of Developmental Biology 11 1.14e-03 6.32e-03 0.74400 -0.506000 -0.546000 3.66e-03 1.72e-03
Disorders of Nervous System Development 11 1.14e-03 6.32e-03 0.74400 -0.506000 -0.546000 3.66e-03 1.72e-03
Loss of function of MECP2 in Rett syndrome 11 1.14e-03 6.32e-03 0.74400 -0.506000 -0.546000 3.66e-03 1.72e-03
Pervasive developmental disorders 11 1.14e-03 6.32e-03 0.74400 -0.506000 -0.546000 3.66e-03 1.72e-03
eNOS activation 11 5.87e-04 3.88e-03 0.73000 -0.669000 -0.293000 1.23e-04 9.21e-02
mRNA Editing 10 4.07e-03 1.67e-02 0.70300 0.517000 0.477000 4.61e-03 9.06e-03
Antimicrobial peptides 69 1.04e-17 8.33e-16 0.69900 0.383000 0.585000 3.76e-08 4.10e-17
Repression of WNT target genes 13 3.67e-04 2.64e-03 0.67700 -0.230000 -0.637000 1.51e-01 6.98e-05
Defective B4GALT7 causes EDS, progeroid type 17 8.16e-05 8.20e-04 0.67500 -0.597000 -0.314000 2.00e-05 2.50e-02
Defective B3GAT3 causes JDSSDHD 17 8.40e-05 8.30e-04 0.67200 -0.598000 -0.308000 1.98e-05 2.81e-02
Crosslinking of collagen fibrils 10 4.51e-03 1.80e-02 0.66000 -0.288000 -0.594000 1.14e-01 1.14e-03
Interaction With Cumulus Cells And The Zona Pellucida 11 4.89e-03 1.91e-02 0.65400 0.517000 0.401000 2.98e-03 2.13e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 12 3.59e-03 1.50e-02 0.64800 -0.423000 -0.491000 1.13e-02 3.20e-03
Defective EXT2 causes exostoses 2 12 3.59e-03 1.50e-02 0.64800 -0.423000 -0.491000 1.13e-02 3.20e-03
Glucuronidation 19 1.31e-04 1.17e-03 0.64600 0.509000 0.398000 1.23e-04 2.69e-03
Metabolism of nitric oxide: NOS3 activation and regulation 15 4.01e-04 2.85e-03 0.63300 -0.589000 -0.231000 7.79e-05 1.21e-01
HS-GAG degradation 18 3.15e-04 2.34e-03 0.62200 -0.518000 -0.345000 1.42e-04 1.12e-02
Keratinization 197 1.30e-36 3.96e-34 0.61500 0.408000 0.461000 5.51e-23 6.53e-29
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 4.53e-04 3.11e-03 0.60900 -0.541000 -0.281000 1.13e-04 4.48e-02
Translocation of ZAP-70 to Immunological synapse 17 7.63e-04 4.69e-03 0.60500 0.500000 0.341000 3.53e-04 1.50e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 4.33e-03 1.75e-02 0.59800 -0.171000 -0.574000 3.27e-01 9.87e-04
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 4.31e-03 1.75e-02 0.58700 -0.361000 -0.463000 1.93e-02 2.70e-03
Aspirin ADME 36 1.54e-06 2.54e-05 0.57600 0.442000 0.371000 4.51e-06 1.19e-04
Phosphorylation of CD3 and TCR zeta chains 20 4.39e-04 3.06e-03 0.57600 0.486000 0.309000 1.70e-04 1.67e-02
Beta-catenin phosphorylation cascade 16 2.53e-03 1.16e-02 0.57300 -0.337000 -0.463000 1.96e-02 1.34e-03
Butyrophilin (BTN) family interactions 12 7.03e-03 2.51e-02 0.57100 0.522000 0.232000 1.73e-03 1.65e-01
RUNX2 regulates bone development 29 3.00e-05 3.48e-04 0.56700 -0.367000 -0.432000 6.22e-04 5.66e-05
Chemokine receptors bind chemokines 52 8.82e-09 2.73e-07 0.56600 0.378000 0.422000 2.47e-06 1.41e-07
Acetylcholine Neurotransmitter Release Cycle 16 3.28e-03 1.39e-02 0.56400 -0.440000 -0.352000 2.30e-03 1.47e-02
Hormone ligand-binding receptors 12 2.60e-03 1.18e-02 0.56100 0.558000 0.063800 8.21e-04 7.02e-01
RUNX2 regulates osteoblast differentiation 22 4.73e-04 3.22e-03 0.55900 -0.371000 -0.418000 2.59e-03 6.90e-04
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 15 2.34e-03 1.10e-02 0.55000 -0.519000 -0.184000 5.01e-04 2.18e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 10 3.48e-02 7.83e-02 0.54900 -0.367000 -0.409000 4.47e-02 2.52e-02
Creation of C4 and C2 activators 14 8.06e-03 2.79e-02 0.54900 0.319000 0.447000 3.88e-02 3.79e-03
Formation of the cornified envelope 68 2.11e-10 8.20e-09 0.54300 0.364000 0.403000 2.05e-07 9.21e-09
Digestion 19 2.00e-03 9.88e-03 0.54300 0.380000 0.388000 4.13e-03 3.44e-03
A tetrasaccharide linker sequence is required for GAG synthesis 23 1.07e-04 9.77e-04 0.54200 -0.515000 -0.170000 1.92e-05 1.58e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 2.97e-02 7.04e-02 0.54200 -0.472000 -0.265000 9.67e-03 1.47e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 1.04e-02 3.33e-02 0.54100 -0.403000 -0.361000 9.02e-03 1.92e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 1.04e-02 3.33e-02 0.54100 -0.403000 -0.361000 9.02e-03 1.92e-02
Scavenging of heme from plasma 11 2.93e-02 6.97e-02 0.53700 0.394000 0.365000 2.37e-02 3.59e-02
Ethanol oxidation 11 2.32e-02 5.90e-02 0.53700 0.271000 0.463000 1.19e-01 7.79e-03
Glucocorticoid biosynthesis 10 1.69e-02 4.73e-02 0.53700 0.136000 0.519000 4.57e-01 4.45e-03
Sensory Perception 508 4.46e-70 2.26e-67 0.53600 0.394000 0.364000 2.89e-52 5.75e-45
ERK/MAPK targets 20 1.80e-03 9.10e-03 0.53300 -0.360000 -0.393000 5.35e-03 2.33e-03
Uptake and function of anthrax toxins 11 2.99e-02 7.04e-02 0.53300 -0.335000 -0.414000 5.42e-02 1.73e-02
CLEC7A (Dectin-1) induces NFAT activation 11 3.14e-02 7.32e-02 0.52600 -0.423000 -0.313000 1.52e-02 7.22e-02
Fatty acids 15 5.09e-03 1.98e-02 0.52500 0.205000 0.483000 1.69e-01 1.20e-03
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 5.89e-03 2.21e-02 0.52100 -0.380000 -0.357000 6.72e-03 1.08e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 5.89e-03 2.21e-02 0.52100 -0.380000 -0.357000 6.72e-03 1.08e-02
Regulation of TP53 Activity through Association with Co-factors 14 1.45e-02 4.21e-02 0.52100 -0.391000 -0.344000 1.12e-02 2.59e-02
LGI-ADAM interactions 14 1.38e-03 7.38e-03 0.52000 -0.520000 0.012000 7.49e-04 9.38e-01
CTNNB1 S33 mutants aren’t phosphorylated 14 1.26e-02 3.82e-02 0.51600 -0.271000 -0.439000 7.91e-02 4.46e-03
CTNNB1 S37 mutants aren’t phosphorylated 14 1.26e-02 3.82e-02 0.51600 -0.271000 -0.439000 7.91e-02 4.46e-03
CTNNB1 S45 mutants aren’t phosphorylated 14 1.26e-02 3.82e-02 0.51600 -0.271000 -0.439000 7.91e-02 4.46e-03
CTNNB1 T41 mutants aren’t phosphorylated 14 1.26e-02 3.82e-02 0.51600 -0.271000 -0.439000 7.91e-02 4.46e-03
Signaling by CTNNB1 phospho-site mutants 14 1.26e-02 3.82e-02 0.51600 -0.271000 -0.439000 7.91e-02 4.46e-03
Signaling by GSK3beta mutants 14 1.26e-02 3.82e-02 0.51600 -0.271000 -0.439000 7.91e-02 4.46e-03
Nephrin family interactions 21 4.84e-04 3.28e-03 0.51500 -0.152000 -0.492000 2.29e-01 9.48e-05
Folding of actin by CCT/TriC 10 2.17e-02 5.62e-02 0.51400 -0.114000 -0.501000 5.32e-01 6.05e-03
ERKs are inactivated 13 2.25e-02 5.76e-02 0.51100 -0.386000 -0.336000 1.60e-02 3.60e-02
AKT phosphorylates targets in the cytosol 14 1.50e-02 4.31e-02 0.51100 -0.421000 -0.289000 6.35e-03 6.14e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 19 1.68e-04 1.45e-03 0.50900 0.023200 -0.509000 8.61e-01 1.23e-04
Serotonin Neurotransmitter Release Cycle 16 1.01e-02 3.30e-02 0.50800 -0.342000 -0.376000 1.79e-02 9.19e-03
Signaling by FGFR2 IIIa TM 19 3.92e-05 4.40e-04 0.50800 0.161000 -0.482000 2.26e-01 2.73e-04
Defective GALNT3 causes HFTC 15 3.73e-03 1.55e-02 0.50600 0.111000 0.494000 4.58e-01 9.19e-04
DARPP-32 events 24 1.09e-03 6.13e-03 0.50600 -0.371000 -0.344000 1.65e-03 3.57e-03
APC truncation mutants have impaired AXIN binding 13 1.83e-02 5.01e-02 0.50500 -0.239000 -0.444000 1.35e-01 5.55e-03
AXIN missense mutants destabilize the destruction complex 13 1.83e-02 5.01e-02 0.50500 -0.239000 -0.444000 1.35e-01 5.55e-03
Signaling by AMER1 mutants 13 1.83e-02 5.01e-02 0.50500 -0.239000 -0.444000 1.35e-01 5.55e-03
Signaling by APC mutants 13 1.83e-02 5.01e-02 0.50500 -0.239000 -0.444000 1.35e-01 5.55e-03
Signaling by AXIN mutants 13 1.83e-02 5.01e-02 0.50500 -0.239000 -0.444000 1.35e-01 5.55e-03
Truncations of AMER1 destabilize the destruction complex 13 1.83e-02 5.01e-02 0.50500 -0.239000 -0.444000 1.35e-01 5.55e-03
Receptor-type tyrosine-protein phosphatases 15 1.44e-02 4.21e-02 0.50400 -0.365000 -0.348000 1.43e-02 1.96e-02
Cell-extracellular matrix interactions 14 1.84e-02 5.03e-02 0.50400 -0.318000 -0.391000 3.91e-02 1.13e-02
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 10 5.18e-02 1.05e-01 0.50100 -0.428000 -0.261000 1.90e-02 1.53e-01
NCAM1 interactions 35 5.74e-05 5.93e-04 0.49800 -0.388000 -0.313000 7.05e-05 1.37e-03
Energy dependent regulation of mTOR by LKB1-AMPK 23 9.05e-04 5.34e-03 0.49800 -0.223000 -0.445000 6.42e-02 2.19e-04
Digestion and absorption 24 1.28e-03 6.90e-03 0.49800 0.316000 0.385000 7.45e-03 1.10e-03
RNA Polymerase III Transcription Termination 23 1.47e-03 7.73e-03 0.49600 -0.278000 -0.411000 2.10e-02 6.49e-04
p75NTR recruits signalling complexes 12 1.01e-02 3.31e-02 0.49600 -0.492000 -0.063900 3.18e-03 7.02e-01
Regulated proteolysis of p75NTR 11 3.18e-02 7.38e-02 0.49600 -0.195000 -0.456000 2.62e-01 8.88e-03
TNFR1-induced proapoptotic signaling 13 2.78e-02 6.70e-02 0.49100 -0.400000 -0.284000 1.24e-02 7.66e-02
Physiological factors 12 1.00e-02 3.30e-02 0.48900 -0.044500 -0.487000 7.89e-01 3.46e-03
Signaling by ALK 26 9.58e-04 5.61e-03 0.48900 -0.311000 -0.376000 5.98e-03 8.94e-04
Constitutive Signaling by AKT1 E17K in Cancer 24 1.75e-03 8.89e-03 0.48800 -0.352000 -0.338000 2.83e-03 4.14e-03
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 6.17e-02 1.20e-01 0.48800 -0.414000 -0.259000 2.35e-02 1.57e-01
SUMOylation of transcription factors 20 4.79e-03 1.89e-02 0.48700 -0.383000 -0.300000 2.99e-03 2.03e-02
MECP2 regulates neuronal receptors and channels 17 1.17e-02 3.66e-02 0.48500 -0.324000 -0.361000 2.08e-02 1.01e-02
Norepinephrine Neurotransmitter Release Cycle 16 1.54e-02 4.40e-02 0.48400 -0.353000 -0.332000 1.45e-02 2.16e-02
Biotin transport and metabolism 10 7.25e-02 1.33e-01 0.48300 -0.302000 -0.377000 9.81e-02 3.90e-02
CD28 dependent Vav1 pathway 11 1.51e-02 4.35e-02 0.48300 0.482000 0.030100 5.65e-03 8.63e-01
Cytosolic iron-sulfur cluster assembly 10 7.49e-02 1.36e-01 0.48200 -0.358000 -0.323000 4.96e-02 7.71e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 3.37e-02 7.71e-02 0.48200 -0.374000 -0.304000 1.95e-02 5.81e-02
Metabolism of Angiotensinogen to Angiotensins 15 1.38e-02 4.11e-02 0.48100 0.211000 0.432000 1.57e-01 3.78e-03
Pexophagy 11 2.27e-02 5.80e-02 0.47900 -0.472000 -0.085900 6.76e-03 6.22e-01
MET activates RAP1 and RAC1 11 3.07e-03 1.31e-02 0.47800 0.326000 -0.349000 6.14e-02 4.49e-02
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 6.14e-02 1.19e-01 0.47700 -0.317000 -0.356000 6.83e-02 4.07e-02
Downregulation of ERBB2:ERBB3 signaling 13 2.04e-02 5.42e-02 0.47700 -0.447000 -0.166000 5.27e-03 2.99e-01
Dectin-2 family 24 2.22e-03 1.04e-02 0.47600 0.297000 0.372000 1.17e-02 1.62e-03
Initial triggering of complement 21 8.03e-04 4.87e-03 0.47200 0.073100 0.466000 5.62e-01 2.18e-04
Defective GALNT12 causes CRCS1 15 1.41e-02 4.17e-02 0.46900 0.177000 0.435000 2.34e-01 3.57e-03
Phase 2 - plateau phase 14 2.71e-02 6.56e-02 0.46800 -0.399000 -0.245000 9.74e-03 1.12e-01
RAF-independent MAPK1/3 activation 22 2.83e-03 1.26e-02 0.46800 -0.218000 -0.415000 7.70e-02 7.58e-04
Activation of SMO 17 1.60e-02 4.55e-02 0.46800 -0.336000 -0.326000 1.66e-02 1.99e-02
Transcriptional Regulation by MECP2 55 1.21e-06 2.08e-05 0.46800 -0.282000 -0.374000 3.02e-04 1.63e-06
Regulation of MECP2 expression and activity 26 1.82e-03 9.17e-03 0.46700 -0.323000 -0.337000 4.30e-03 2.90e-03
Initiation of Nuclear Envelope (NE) Reformation 18 1.21e-02 3.74e-02 0.46700 -0.291000 -0.365000 3.25e-02 7.33e-03
ALK mutants bind TKIs 12 4.75e-02 9.92e-02 0.46400 -0.240000 -0.397000 1.50e-01 1.72e-02
Activation of AMPK downstream of NMDARs 10 9.27e-02 1.61e-01 0.46300 -0.320000 -0.334000 7.94e-02 6.74e-02
Fertilization 22 4.80e-03 1.89e-02 0.46200 0.373000 0.273000 2.48e-03 2.67e-02
Interleukin-10 signaling 43 3.55e-05 4.07e-04 0.46200 0.298000 0.353000 7.13e-04 6.31e-05
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 28 1.16e-03 6.40e-03 0.46100 -0.274000 -0.371000 1.22e-02 6.84e-04
Transcriptional regulation of granulopoiesis 30 6.95e-04 4.46e-03 0.46100 -0.375000 -0.267000 3.76e-04 1.13e-02
Signaling by Hippo 17 6.08e-03 2.26e-02 0.46000 -0.115000 -0.445000 4.13e-01 1.48e-03
Adenylate cyclase activating pathway 10 6.81e-02 1.28e-01 0.45900 -0.422000 -0.180000 2.09e-02 3.23e-01
Nuclear Events (kinase and transcription factor activation) 60 8.68e-07 1.61e-05 0.45800 -0.322000 -0.326000 1.60e-05 1.27e-05
Complement cascade 53 3.71e-06 5.92e-05 0.45200 0.251000 0.376000 1.58e-03 2.17e-06
Synaptic adhesion-like molecules 19 1.24e-02 3.82e-02 0.45200 -0.358000 -0.275000 6.83e-03 3.77e-02
RET signaling 41 7.97e-05 8.07e-04 0.44900 -0.263000 -0.364000 3.56e-03 5.39e-05
NF-kB is activated and signals survival 12 3.97e-02 8.55e-02 0.44900 -0.423000 -0.150000 1.11e-02 3.69e-01
cGMP effects 15 1.03e-02 3.33e-02 0.44900 -0.073700 -0.443000 6.21e-01 2.99e-03
p75NTR signals via NF-kB 15 1.73e-02 4.82e-02 0.44800 -0.425000 -0.142000 4.39e-03 3.41e-01
Adenylate cyclase inhibitory pathway 13 4.87e-02 1.01e-01 0.44800 -0.374000 -0.246000 1.95e-02 1.25e-01
Processing of Intronless Pre-mRNAs 19 2.99e-03 1.31e-02 0.44700 -0.065900 -0.442000 6.19e-01 8.58e-04
Negative regulation of NMDA receptor-mediated neuronal transmission 20 1.17e-02 3.65e-02 0.44600 -0.291000 -0.338000 2.42e-02 8.83e-03
Regulation of localization of FOXO transcription factors 10 4.27e-02 9.09e-02 0.44400 -0.442000 -0.040300 1.55e-02 8.25e-01
Regulation of gene expression in beta cells 21 6.45e-03 2.35e-02 0.44400 -0.394000 -0.204000 1.76e-03 1.06e-01
Protein-protein interactions at synapses 77 4.91e-08 1.33e-06 0.44300 -0.294000 -0.332000 8.12e-06 4.78e-07
NGF-stimulated transcription 39 2.05e-04 1.66e-03 0.44300 -0.309000 -0.317000 8.35e-04 6.02e-04
PD-1 signaling 21 1.03e-02 3.33e-02 0.44300 0.326000 0.300000 9.73e-03 1.75e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 4.86e-02 1.01e-01 0.44300 -0.169000 -0.409000 3.12e-01 1.41e-02
alpha-linolenic acid (ALA) metabolism 12 4.86e-02 1.01e-01 0.44300 -0.169000 -0.409000 3.12e-01 1.41e-02
Phase 4 - resting membrane potential 19 2.73e-03 1.23e-02 0.44300 -0.440000 -0.045300 8.93e-04 7.33e-01
Regulation of Complement cascade 42 8.36e-05 8.30e-04 0.43900 0.238000 0.368000 7.58e-03 3.60e-05
Assembly Of The HIV Virion 14 2.26e-02 5.78e-02 0.43800 -0.423000 -0.111000 6.12e-03 4.71e-01
Defective C1GALT1C1 causes TNPS 15 3.34e-02 7.65e-02 0.43700 0.220000 0.377000 1.40e-01 1.14e-02
Regulation of TLR by endogenous ligand 17 2.79e-02 6.70e-02 0.43500 0.311000 0.305000 2.65e-02 2.94e-02
RMTs methylate histone arginines 29 1.39e-03 7.41e-03 0.43500 -0.213000 -0.380000 4.70e-02 4.03e-04
MAPK targets/ Nuclear events mediated by MAP kinases 29 2.27e-03 1.06e-02 0.43400 -0.292000 -0.322000 6.55e-03 2.70e-03
Dopamine Neurotransmitter Release Cycle 20 1.44e-02 4.21e-02 0.43400 -0.272000 -0.339000 3.52e-02 8.76e-03
Base-Excision Repair, AP Site Formation 18 2.37e-02 5.98e-02 0.43300 -0.299000 -0.313000 2.81e-02 2.16e-02
HS-GAG biosynthesis 28 2.06e-03 1.00e-02 0.43200 -0.221000 -0.371000 4.27e-02 6.68e-04
Presynaptic depolarization and calcium channel opening 12 7.56e-02 1.37e-01 0.43200 -0.358000 -0.242000 3.18e-02 1.47e-01
CRMPs in Sema3A signaling 15 1.38e-02 4.11e-02 0.42900 -0.056400 -0.425000 7.05e-01 4.35e-03
HDACs deacetylate histones 29 2.02e-03 9.93e-03 0.42800 -0.361000 -0.231000 7.60e-04 3.16e-02
MTOR signalling 35 6.90e-04 4.46e-03 0.42800 -0.254000 -0.345000 9.41e-03 4.19e-04
RHO GTPases activate IQGAPs 11 1.00e-02 3.30e-02 0.42800 0.260000 -0.340000 1.36e-01 5.09e-02
Neurexins and neuroligins 52 2.15e-05 2.63e-04 0.42800 -0.259000 -0.340000 1.24e-03 2.18e-05
Synthesis of PE 11 6.87e-02 1.29e-01 0.42700 -0.403000 -0.140000 2.07e-02 4.20e-01
Reduction of cytosolic Ca++ levels 11 1.08e-01 1.82e-01 0.42600 -0.280000 -0.320000 1.08e-01 6.59e-02
CaMK IV-mediated phosphorylation of CREB 10 1.22e-01 1.99e-01 0.42400 -0.227000 -0.358000 2.13e-01 4.97e-02
MicroRNA (miRNA) biogenesis 21 2.47e-03 1.14e-02 0.42200 -0.037400 -0.421000 7.67e-01 8.45e-04
PKA-mediated phosphorylation of CREB 19 1.97e-02 5.29e-02 0.42200 -0.353000 -0.231000 7.67e-03 8.13e-02
EGR2 and SOX10-mediated initiation of Schwann cell myelination 25 3.73e-03 1.55e-02 0.42200 -0.174000 -0.384000 1.31e-01 8.90e-04
SUMOylation of intracellular receptors 29 3.06e-03 1.31e-02 0.42100 -0.332000 -0.258000 1.96e-03 1.61e-02
HIV elongation arrest and recovery 25 8.56e-04 5.08e-03 0.42000 -0.037100 -0.418000 7.48e-01 2.95e-04
Pausing and recovery of HIV elongation 25 8.56e-04 5.08e-03 0.42000 -0.037100 -0.418000 7.48e-01 2.95e-04
RNA Polymerase III Chain Elongation 18 1.81e-02 5.01e-02 0.41900 -0.170000 -0.384000 2.13e-01 4.83e-03
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 12 9.52e-02 1.64e-01 0.41900 -0.316000 -0.276000 5.83e-02 9.82e-02
CS/DS degradation 12 4.90e-02 1.01e-01 0.41900 -0.407000 -0.100000 1.46e-02 5.48e-01
Receptor Mediated Mitophagy 10 1.04e-01 1.76e-01 0.41800 -0.388000 -0.156000 3.38e-02 3.93e-01
Pausing and recovery of Tat-mediated HIV elongation 23 1.60e-03 8.19e-03 0.41800 -0.036100 -0.416000 7.65e-01 5.51e-04
Tat-mediated HIV elongation arrest and recovery 23 1.60e-03 8.19e-03 0.41800 -0.036100 -0.416000 7.65e-01 5.51e-04
Laminin interactions 23 9.65e-03 3.23e-02 0.41700 -0.228000 -0.349000 5.78e-02 3.76e-03
FGFR2 alternative splicing 25 1.45e-03 7.69e-03 0.41500 -0.067900 -0.410000 5.57e-01 3.90e-04
TRAF3-dependent IRF activation pathway 14 1.02e-02 3.31e-02 0.41500 0.069400 -0.409000 6.53e-01 8.10e-03
Signaling by PDGFRA extracellular domain mutants 12 3.26e-02 7.49e-02 0.41400 -0.015400 -0.414000 9.26e-01 1.31e-02
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 3.26e-02 7.49e-02 0.41400 -0.015400 -0.414000 9.26e-01 1.31e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.10e-03 1.01e-02 0.41400 -0.138000 -0.390000 2.14e-01 4.46e-04
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 2.92e-05 3.42e-04 0.41400 -0.233000 -0.342000 3.37e-03 1.64e-05
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 2.92e-05 3.42e-04 0.41400 -0.233000 -0.342000 3.37e-03 1.64e-05
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 2.92e-05 3.42e-04 0.41400 -0.233000 -0.342000 3.37e-03 1.64e-05
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 2.92e-05 3.42e-04 0.41400 -0.233000 -0.342000 3.37e-03 1.64e-05
Signaling by NOTCH1 in Cancer 53 2.92e-05 3.42e-04 0.41400 -0.233000 -0.342000 3.37e-03 1.64e-05
Nitric oxide stimulates guanylate cyclase 22 4.81e-03 1.89e-02 0.41300 -0.103000 -0.400000 4.03e-01 1.15e-03
Deposition of new CENPA-containing nucleosomes at the centromere 21 1.25e-02 3.82e-02 0.41300 -0.188000 -0.368000 1.36e-01 3.52e-03
Nucleosome assembly 21 1.25e-02 3.82e-02 0.41300 -0.188000 -0.368000 1.36e-01 3.52e-03
Glutathione synthesis and recycling 13 5.09e-02 1.04e-01 0.41300 -0.391000 -0.133000 1.47e-02 4.07e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 6.56e-02 1.25e-01 0.41200 -0.389000 -0.136000 1.96e-02 4.16e-01
Collagen biosynthesis and modifying enzymes 57 1.93e-05 2.44e-04 0.41200 -0.321000 -0.258000 2.75e-05 7.48e-04
Activation of RAC1 11 1.11e-01 1.86e-01 0.41200 -0.212000 -0.352000 2.23e-01 4.30e-02
Interleukin-37 signaling 19 2.28e-02 5.81e-02 0.41100 -0.351000 -0.215000 8.07e-03 1.05e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 15 2.00e-02 5.33e-02 0.41100 -0.056900 -0.407000 7.03e-01 6.34e-03
PKA activation in glucagon signalling 17 3.51e-02 7.85e-02 0.41100 -0.347000 -0.220000 1.33e-02 1.16e-01
MET receptor recycling 10 4.08e-02 8.75e-02 0.41100 0.065000 -0.406000 7.22e-01 2.64e-02
Activation of ATR in response to replication stress 30 6.39e-04 4.18e-03 0.41000 -0.088700 -0.401000 4.00e-01 1.45e-04
Recycling of bile acids and salts 16 3.92e-02 8.46e-02 0.41000 0.196000 0.360000 1.75e-01 1.27e-02
Dissolution of Fibrin Clot 13 8.89e-02 1.56e-01 0.40900 0.277000 0.301000 8.38e-02 6.01e-02
Signaling by NOTCH1 69 8.35e-07 1.56e-05 0.40900 -0.190000 -0.362000 6.30e-03 1.99e-07
PKA activation 18 3.29e-02 7.55e-02 0.40800 -0.331000 -0.239000 1.51e-02 7.96e-02
NOTCH1 Intracellular Domain Regulates Transcription 44 2.94e-04 2.23e-03 0.40600 -0.259000 -0.313000 2.94e-03 3.27e-04
Na+/Cl- dependent neurotransmitter transporters 18 4.70e-03 1.87e-02 0.40500 -0.404000 0.035000 3.01e-03 7.97e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 2.08e-02 5.48e-02 0.40500 -0.175000 -0.365000 1.87e-01 5.82e-03
Signaling by WNT in cancer 32 2.50e-03 1.15e-02 0.40300 -0.224000 -0.334000 2.80e-02 1.06e-03
GABA synthesis, release, reuptake and degradation 19 3.16e-02 7.35e-02 0.40200 -0.312000 -0.254000 1.86e-02 5.48e-02
Membrane binding and targetting of GAG proteins 12 5.17e-02 1.05e-01 0.40100 -0.397000 -0.058500 1.74e-02 7.26e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 5.17e-02 1.05e-01 0.40100 -0.397000 -0.058500 1.74e-02 7.26e-01
Formation of apoptosome 10 7.11e-02 1.32e-01 0.40100 -0.400000 -0.021100 2.84e-02 9.08e-01
Regulation of the apoptosome activity 10 7.11e-02 1.32e-01 0.40100 -0.400000 -0.021100 2.84e-02 9.08e-01
DAG and IP3 signaling 39 5.02e-04 3.37e-03 0.40100 -0.187000 -0.354000 4.32e-02 1.28e-04
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 4.72e-03 1.87e-02 0.40000 -0.302000 -0.262000 4.20e-03 1.29e-02
EPH-ephrin mediated repulsion of cells 48 8.95e-05 8.65e-04 0.40000 -0.186000 -0.354000 2.62e-02 2.18e-05
Formation of the beta-catenin:TCF transactivating complex 31 1.54e-03 8.00e-03 0.40000 -0.143000 -0.373000 1.68e-01 3.23e-04
Activation of BH3-only proteins 30 4.87e-03 1.90e-02 0.40000 -0.295000 -0.270000 5.18e-03 1.06e-02
Deactivation of the beta-catenin transactivating complex 38 1.22e-03 6.63e-03 0.39700 -0.307000 -0.252000 1.06e-03 7.26e-03
Dermatan sulfate biosynthesis 10 1.67e-01 2.49e-01 0.39700 -0.320000 -0.235000 7.98e-02 1.99e-01
Formation of the Early Elongation Complex 28 7.60e-04 4.69e-03 0.39700 -0.025400 -0.396000 8.16e-01 2.89e-04
Formation of the HIV-1 Early Elongation Complex 28 7.60e-04 4.69e-03 0.39700 -0.025400 -0.396000 8.16e-01 2.89e-04
Collagen chain trimerization 39 9.80e-04 5.70e-03 0.39700 -0.315000 -0.241000 6.65e-04 9.23e-03
Downstream signal transduction 29 5.70e-03 2.16e-02 0.39600 -0.237000 -0.318000 2.73e-02 3.05e-03
Purine ribonucleoside monophosphate biosynthesis 11 1.44e-01 2.25e-01 0.39600 -0.307000 -0.251000 7.81e-02 1.50e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 26 1.09e-02 3.48e-02 0.39500 -0.263000 -0.295000 2.01e-02 9.28e-03
Processing of Capped Intronless Pre-mRNA 28 1.11e-03 6.22e-03 0.39500 -0.050000 -0.392000 6.47e-01 3.31e-04
Regulation of cholesterol biosynthesis by SREBP (SREBF) 52 1.25e-04 1.12e-03 0.39500 -0.278000 -0.281000 5.31e-04 4.61e-04
Glutamate Neurotransmitter Release Cycle 23 1.53e-02 4.39e-02 0.39500 -0.333000 -0.212000 5.71e-03 7.79e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 21 2.33e-02 5.91e-02 0.39500 -0.225000 -0.324000 7.42e-02 1.01e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 2.07e-02 5.48e-02 0.39500 0.069300 -0.388000 6.65e-01 1.53e-02
Cholesterol biosynthesis 22 1.65e-02 4.64e-02 0.39400 -0.345000 -0.192000 5.12e-03 1.20e-01
Role of LAT2/NTAL/LAB on calcium mobilization 13 1.13e-02 3.57e-02 0.39400 0.197000 -0.341000 2.19e-01 3.33e-02
HDMs demethylate histones 17 2.08e-02 5.48e-02 0.39300 -0.079300 -0.385000 5.71e-01 5.96e-03
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 1.45e-02 4.21e-02 0.39300 -0.143000 -0.366000 2.58e-01 3.65e-03
Neurodegenerative Diseases 21 1.45e-02 4.21e-02 0.39300 -0.143000 -0.366000 2.58e-01 3.65e-03
VEGFR2 mediated cell proliferation 19 3.57e-02 7.91e-02 0.39300 -0.234000 -0.316000 7.77e-02 1.71e-02
Regulation of beta-cell development 41 8.35e-04 5.03e-03 0.39200 -0.305000 -0.246000 7.13e-04 6.33e-03
Activation of BAD and translocation to mitochondria 15 5.53e-02 1.10e-01 0.39200 -0.356000 -0.164000 1.68e-02 2.72e-01
Long-term potentiation 22 2.36e-02 5.95e-02 0.39100 -0.295000 -0.257000 1.68e-02 3.70e-02
Signal attenuation 10 1.14e-01 1.89e-01 0.39100 -0.096100 -0.379000 5.99e-01 3.81e-02
RHOC GTPase cycle 63 5.92e-06 8.89e-05 0.39000 -0.162000 -0.355000 2.63e-02 1.08e-06
Neurotoxicity of clostridium toxins 10 1.57e-01 2.40e-01 0.39000 -0.346000 -0.180000 5.84e-02 3.24e-01
Diseases associated with glycosylation precursor biosynthesis 15 2.13e-02 5.55e-02 0.39000 -0.005820 -0.390000 9.69e-01 9.00e-03
Cytochrome c-mediated apoptotic response 12 9.33e-02 1.62e-01 0.39000 -0.363000 -0.142000 2.95e-02 3.95e-01
Activation of HOX genes during differentiation 57 9.63e-06 1.35e-04 0.38900 -0.127000 -0.368000 9.77e-02 1.54e-06
Activation of anterior HOX genes in hindbrain development during early embryogenesis 57 9.63e-06 1.35e-04 0.38900 -0.127000 -0.368000 9.77e-02 1.54e-06
Unblocking of NMDA receptors, glutamate binding and activation 19 4.07e-02 8.75e-02 0.38900 -0.261000 -0.288000 4.86e-02 2.95e-02
EPHB-mediated forward signaling 33 3.35e-03 1.42e-02 0.38900 -0.227000 -0.316000 2.41e-02 1.67e-03
Cleavage of the damaged pyrimidine 16 6.96e-02 1.30e-01 0.38700 -0.279000 -0.269000 5.36e-02 6.25e-02
Depyrimidination 16 6.96e-02 1.30e-01 0.38700 -0.279000 -0.269000 5.36e-02 6.25e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 16 6.96e-02 1.30e-01 0.38700 -0.279000 -0.269000 5.36e-02 6.25e-02
Zinc influx into cells by the SLC39 gene family 10 1.32e-01 2.09e-01 0.38700 -0.368000 -0.120000 4.41e-02 5.12e-01
Activation of NMDA receptors and postsynaptic events 69 1.06e-05 1.46e-04 0.38700 -0.258000 -0.288000 2.12e-04 3.51e-05
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 4.34e-03 1.75e-02 0.38600 -0.141000 -0.360000 1.97e-01 9.82e-04
DNA Damage/Telomere Stress Induced Senescence 28 8.99e-03 3.04e-02 0.38600 -0.237000 -0.305000 2.99e-02 5.22e-03
TP53 Regulates Transcription of Death Receptors and Ligands 12 1.27e-01 2.04e-01 0.38600 -0.320000 -0.216000 5.48e-02 1.95e-01
MyD88 deficiency (TLR2/4) 16 5.25e-02 1.06e-01 0.38600 0.170000 0.347000 2.39e-01 1.63e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 1.58e-01 2.41e-01 0.38600 -0.242000 -0.300000 1.64e-01 8.45e-02
NCAM signaling for neurite out-growth 56 1.00e-04 9.34e-04 0.38400 -0.291000 -0.251000 1.66e-04 1.17e-03
Notch-HLH transcription pathway 24 1.95e-02 5.26e-02 0.38400 -0.287000 -0.254000 1.48e-02 3.10e-02
Presynaptic nicotinic acetylcholine receptors 12 3.55e-02 7.89e-02 0.38300 -0.059700 0.379000 7.20e-01 2.31e-02
RND1 GTPase cycle 40 1.31e-03 7.01e-03 0.38300 -0.232000 -0.305000 1.11e-02 8.45e-04
Condensation of Prophase Chromosomes 12 1.25e-01 2.02e-01 0.38300 -0.197000 -0.328000 2.38e-01 4.88e-02
TNFR1-induced NFkappaB signaling pathway 20 3.67e-02 8.07e-02 0.38300 -0.236000 -0.301000 6.72e-02 1.97e-02
Activation of the TFAP2 (AP-2) family of transcription factors 11 1.69e-01 2.52e-01 0.38100 -0.255000 -0.283000 1.43e-01 1.04e-01
Tandem pore domain potassium channels 12 6.60e-02 1.25e-01 0.38000 -0.378000 -0.046200 2.35e-02 7.82e-01
Heparan sulfate/heparin (HS-GAG) metabolism 49 3.24e-04 2.40e-03 0.38000 -0.306000 -0.225000 2.10e-04 6.37e-03
Signaling by PDGFR in disease 20 2.70e-02 6.55e-02 0.37900 -0.157000 -0.345000 2.25e-01 7.55e-03
Signaling by NTRK1 (TRKA) 114 9.71e-09 2.95e-07 0.37900 -0.227000 -0.303000 2.86e-05 2.28e-08
TNF signaling 37 2.68e-03 1.21e-02 0.37800 -0.293000 -0.239000 2.05e-03 1.20e-02
Glycogen breakdown (glycogenolysis) 12 1.26e-01 2.03e-01 0.37700 -0.334000 -0.176000 4.53e-02 2.91e-01
SUMOylation of immune response proteins 10 1.98e-01 2.81e-01 0.37700 -0.222000 -0.305000 2.25e-01 9.47e-02
Senescence-Associated Secretory Phenotype (SASP) 49 1.99e-04 1.66e-03 0.37700 -0.336000 -0.170000 4.65e-05 3.94e-02
mRNA Capping 28 2.18e-03 1.03e-02 0.37600 -0.051100 -0.373000 6.40e-01 6.40e-04
Netrin-1 signaling 49 4.09e-04 2.88e-03 0.37600 -0.230000 -0.297000 5.39e-03 3.18e-04
Translesion synthesis by POLI 17 7.11e-02 1.32e-01 0.37400 -0.253000 -0.275000 7.04e-02 4.96e-02
Ca2+ pathway 58 3.78e-05 4.28e-04 0.37400 -0.154000 -0.341000 4.23e-02 7.25e-06
Formation of HIV elongation complex in the absence of HIV Tat 36 3.83e-04 2.74e-03 0.37300 -0.043600 -0.371000 6.51e-01 1.18e-04
CaM pathway 33 5.21e-03 2.01e-02 0.37300 -0.212000 -0.307000 3.53e-02 2.31e-03
Calmodulin induced events 33 5.21e-03 2.01e-02 0.37300 -0.212000 -0.307000 3.53e-02 2.31e-03
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11 1.20e-01 1.96e-01 0.37200 0.104000 0.358000 5.52e-01 4.00e-02
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 3.19e-02 7.38e-02 0.37100 -0.130000 -0.348000 3.25e-01 8.68e-03
Cleavage of the damaged purine 11 1.79e-01 2.63e-01 0.37100 -0.219000 -0.299000 2.08e-01 8.63e-02
Depurination 11 1.79e-01 2.63e-01 0.37100 -0.219000 -0.299000 2.08e-01 8.63e-02
Recognition and association of DNA glycosylase with site containing an affected purine 11 1.79e-01 2.63e-01 0.37100 -0.219000 -0.299000 2.08e-01 8.63e-02
RNA Polymerase III Abortive And Retractive Initiation 41 1.53e-03 7.96e-03 0.37000 -0.207000 -0.307000 2.17e-02 6.69e-04
RNA Polymerase III Transcription 41 1.53e-03 7.96e-03 0.37000 -0.207000 -0.307000 2.17e-02 6.69e-04
Signaling by Non-Receptor Tyrosine Kinases 53 2.05e-04 1.66e-03 0.37000 -0.315000 -0.194000 7.38e-05 1.45e-02
Signaling by PTK6 53 2.05e-04 1.66e-03 0.37000 -0.315000 -0.194000 7.38e-05 1.45e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 6.52e-02 1.25e-01 0.37000 0.033300 -0.368000 8.48e-01 3.45e-02
RND3 GTPase cycle 40 2.09e-03 1.01e-02 0.36900 -0.222000 -0.295000 1.52e-02 1.25e-03
Formation of HIV-1 elongation complex containing HIV-1 Tat 34 7.02e-04 4.46e-03 0.36900 -0.043200 -0.366000 6.63e-01 2.17e-04
HIV Transcription Elongation 34 7.02e-04 4.46e-03 0.36900 -0.043200 -0.366000 6.63e-01 2.17e-04
Tat-mediated elongation of the HIV-1 transcript 34 7.02e-04 4.46e-03 0.36900 -0.043200 -0.366000 6.63e-01 2.17e-04
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 114 3.49e-09 1.13e-07 0.36900 0.150000 0.337000 5.57e-03 5.36e-10
Metabolism of folate and pterines 16 5.05e-02 1.04e-01 0.36800 -0.107000 -0.352000 4.58e-01 1.47e-02
VxPx cargo-targeting to cilium 20 2.17e-02 5.63e-02 0.36800 -0.094500 -0.356000 4.65e-01 5.85e-03
Early Phase of HIV Life Cycle 14 9.20e-02 1.61e-01 0.36800 -0.152000 -0.335000 3.24e-01 2.99e-02
Estrogen-dependent gene expression 87 7.89e-07 1.52e-05 0.36800 -0.180000 -0.321000 3.63e-03 2.34e-07
NRAGE signals death through JNK 47 1.14e-04 1.03e-03 0.36800 -0.087700 -0.357000 2.98e-01 2.29e-05
Platelet calcium homeostasis 27 1.77e-02 4.92e-02 0.36600 -0.235000 -0.280000 3.43e-02 1.19e-02
Regulation of PTEN mRNA translation 21 3.13e-02 7.31e-02 0.36500 0.160000 0.328000 2.03e-01 9.23e-03
Diseases of mitotic cell cycle 35 3.44e-03 1.45e-02 0.36500 -0.324000 -0.168000 9.17e-04 8.54e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 5.48e-04 3.65e-03 0.36500 -0.221000 -0.290000 6.75e-03 3.93e-04
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 5.09e-03 1.98e-02 0.36500 -0.036200 -0.363000 7.54e-01 1.69e-03
RORA activates gene expression 16 2.94e-02 6.98e-02 0.36400 -0.014800 -0.364000 9.18e-01 1.17e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 12 8.02e-02 1.44e-01 0.36400 -0.038000 -0.362000 8.20e-01 2.98e-02
Sulfur amino acid metabolism 27 1.93e-02 5.21e-02 0.36300 -0.264000 -0.249000 1.75e-02 2.53e-02
Rap1 signalling 16 9.70e-02 1.67e-01 0.36200 -0.254000 -0.258000 7.80e-02 7.39e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 34 7.02e-03 2.51e-02 0.36200 -0.269000 -0.242000 6.61e-03 1.45e-02
Regulation of PTEN gene transcription 54 3.06e-04 2.29e-03 0.36200 -0.297000 -0.207000 1.63e-04 8.40e-03
Apoptotic factor-mediated response 17 5.17e-02 1.05e-01 0.36200 -0.341000 -0.121000 1.49e-02 3.89e-01
Pentose phosphate pathway 11 1.89e-01 2.71e-01 0.36100 -0.199000 -0.302000 2.54e-01 8.30e-02
Negative regulation of MAPK pathway 41 2.52e-03 1.15e-02 0.36100 -0.277000 -0.232000 2.15e-03 1.01e-02
Golgi Associated Vesicle Biogenesis 48 6.22e-04 4.09e-03 0.36100 -0.186000 -0.310000 2.59e-02 2.05e-04
Assembly and cell surface presentation of NMDA receptors 23 3.56e-02 7.91e-02 0.36100 -0.268000 -0.242000 2.63e-02 4.42e-02
Signaling by PDGF 51 4.87e-04 3.29e-03 0.36000 -0.199000 -0.300000 1.40e-02 2.12e-04
Regulation of RUNX1 Expression and Activity 19 5.07e-02 1.04e-01 0.36000 -0.318000 -0.169000 1.65e-02 2.03e-01
Protein methylation 11 1.82e-01 2.65e-01 0.35900 -0.174000 -0.314000 3.17e-01 7.14e-02
Chondroitin sulfate/dermatan sulfate metabolism 45 7.73e-04 4.72e-03 0.35900 -0.323000 -0.157000 1.80e-04 6.78e-02
NRIF signals cell death from the nucleus 16 1.02e-01 1.73e-01 0.35800 -0.263000 -0.243000 6.80e-02 9.23e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 39 1.88e-03 9.40e-03 0.35800 -0.148000 -0.326000 1.09e-01 4.31e-04
Sensory processing of sound by outer hair cells of the cochlea 46 1.22e-03 6.63e-03 0.35800 -0.209000 -0.290000 1.41e-02 6.59e-04
Post NMDA receptor activation events 58 2.47e-04 1.94e-03 0.35800 -0.226000 -0.277000 2.87e-03 2.65e-04
p75 NTR receptor-mediated signalling 82 5.04e-06 7.73e-05 0.35700 -0.189000 -0.303000 3.11e-03 2.12e-06
DCC mediated attractive signaling 14 9.57e-02 1.65e-01 0.35600 -0.122000 -0.334000 4.28e-01 3.03e-02
Eicosanoids 12 1.82e-01 2.65e-01 0.35600 0.228000 0.274000 1.72e-01 1.01e-01
Defective Intrinsic Pathway for Apoptosis 24 2.43e-02 6.03e-02 0.35600 -0.162000 -0.317000 1.70e-01 7.20e-03
Collagen formation 77 2.09e-05 2.58e-04 0.35500 -0.242000 -0.260000 2.45e-04 7.81e-05
Association of TriC/CCT with target proteins during biosynthesis 38 2.14e-03 1.02e-02 0.35500 -0.137000 -0.328000 1.44e-01 4.70e-04
RHOBTB1 GTPase cycle 22 4.52e-02 9.48e-02 0.35500 -0.270000 -0.230000 2.82e-02 6.17e-02
Transport of Mature mRNA Derived from an Intronless Transcript 38 2.82e-03 1.26e-02 0.35300 -0.154000 -0.318000 1.01e-01 6.93e-04
Endosomal Sorting Complex Required For Transport (ESCRT) 28 6.08e-03 2.26e-02 0.35300 -0.345000 -0.073500 1.57e-03 5.01e-01
RNA Pol II CTD phosphorylation and interaction with CE 26 8.93e-03 3.03e-02 0.35300 -0.074800 -0.345000 5.09e-01 2.36e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 26 8.93e-03 3.03e-02 0.35300 -0.074800 -0.345000 5.09e-01 2.36e-03
Aberrant regulation of mitotic cell cycle due to RB1 defects 34 6.62e-03 2.39e-02 0.35200 -0.305000 -0.175000 2.05e-03 7.79e-02
Common Pathway of Fibrin Clot Formation 21 5.06e-02 1.04e-01 0.35100 0.197000 0.291000 1.17e-01 2.12e-02
TP53 Regulates Transcription of DNA Repair Genes 52 5.79e-05 5.93e-04 0.35100 -0.054400 -0.347000 4.97e-01 1.52e-05
Synthesis of PC 27 1.75e-02 4.88e-02 0.35100 -0.311000 -0.163000 5.16e-03 1.43e-01
trans-Golgi Network Vesicle Budding 64 8.42e-05 8.30e-04 0.35100 -0.174000 -0.305000 1.60e-02 2.49e-05
RHO GTPases Activate Formins 111 1.11e-08 3.30e-07 0.35000 -0.111000 -0.332000 4.38e-02 1.43e-09
Signaling by NTRKs 132 6.08e-09 1.92e-07 0.35000 -0.184000 -0.298000 2.69e-04 3.26e-09
Activation of gene expression by SREBF (SREBP) 40 4.10e-03 1.68e-02 0.35000 -0.222000 -0.271000 1.53e-02 3.00e-03
Cell death signalling via NRAGE, NRIF and NADE 63 5.01e-05 5.32e-04 0.35000 -0.133000 -0.323000 6.69e-02 8.99e-06
Activated NOTCH1 Transmits Signal to the Nucleus 30 9.72e-03 3.23e-02 0.35000 -0.142000 -0.320000 1.79e-01 2.45e-03
Assembly of collagen fibrils and other multimeric structures 51 9.61e-04 5.61e-03 0.34900 -0.222000 -0.269000 6.01e-03 8.95e-04
RHOBTB GTPase Cycle 33 1.10e-02 3.51e-02 0.34900 -0.272000 -0.218000 6.80e-03 3.03e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.09e-01 2.94e-01 0.34900 -0.185000 -0.296000 2.89e-01 8.95e-02
Signaling by Activin 15 1.30e-01 2.07e-01 0.34900 -0.221000 -0.269000 1.38e-01 7.09e-02
Resolution of Sister Chromatid Cohesion 95 2.59e-07 5.86e-06 0.34700 -0.117000 -0.327000 4.80e-02 3.64e-08
G1/S-Specific Transcription 26 2.93e-02 6.97e-02 0.34700 -0.213000 -0.274000 5.97e-02 1.57e-02
Signaling by NTRK2 (TRKB) 25 6.77e-03 2.44e-02 0.34600 -0.012000 -0.346000 9.17e-01 2.74e-03
Sensory processing of sound by inner hair cells of the cochlea 61 2.96e-04 2.24e-03 0.34600 -0.226000 -0.262000 2.28e-03 4.07e-04
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 7.88e-02 1.42e-01 0.34500 -0.219000 -0.267000 9.79e-02 4.41e-02
Generation of second messenger molecules 30 1.61e-02 4.55e-02 0.34500 0.287000 0.192000 6.53e-03 6.88e-02
Transport of organic anions 10 1.02e-01 1.73e-01 0.34500 -0.062300 0.339000 7.33e-01 6.33e-02
Defects in vitamin and cofactor metabolism 20 6.08e-02 1.19e-01 0.34500 -0.179000 -0.295000 1.67e-01 2.24e-02
Polymerase switching on the C-strand of the telomere 22 3.84e-02 8.32e-02 0.34500 -0.146000 -0.312000 2.35e-01 1.13e-02
SLBP independent Processing of Histone Pre-mRNAs 10 1.16e-01 1.92e-01 0.34400 0.030400 -0.343000 8.68e-01 6.03e-02
FOXO-mediated transcription 62 2.90e-04 2.21e-03 0.34400 -0.248000 -0.239000 7.24e-04 1.15e-03
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 41 4.41e-03 1.78e-02 0.34400 -0.218000 -0.266000 1.57e-02 3.25e-03
Calcitonin-like ligand receptors 10 2.42e-01 3.30e-01 0.34400 -0.300000 -0.167000 1.00e-01 3.61e-01
Transcriptional regulation by RUNX2 116 1.83e-07 4.56e-06 0.34300 -0.202000 -0.277000 1.66e-04 2.43e-07
MyD88 cascade initiated on plasma membrane 77 4.33e-05 4.73e-04 0.34300 -0.240000 -0.246000 2.75e-04 1.94e-04
Toll Like Receptor 10 (TLR10) Cascade 77 4.33e-05 4.73e-04 0.34300 -0.240000 -0.246000 2.75e-04 1.94e-04
Toll Like Receptor 5 (TLR5) Cascade 77 4.33e-05 4.73e-04 0.34300 -0.240000 -0.246000 2.75e-04 1.94e-04
Ca-dependent events 35 8.36e-03 2.88e-02 0.34300 -0.187000 -0.288000 5.54e-02 3.22e-03
Budding and maturation of HIV virion 25 1.93e-02 5.21e-02 0.34300 -0.325000 -0.110000 4.96e-03 3.42e-01
Platelet sensitization by LDL 17 9.30e-02 1.61e-01 0.34200 -0.171000 -0.297000 2.23e-01 3.41e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 86 1.25e-06 2.10e-05 0.34200 -0.107000 -0.325000 8.74e-02 1.86e-07
Amplification of signal from the kinetochores 86 1.25e-06 2.10e-05 0.34200 -0.107000 -0.325000 8.74e-02 1.86e-07
Translesion synthesis by REV1 16 1.22e-01 1.99e-01 0.34200 -0.215000 -0.266000 1.37e-01 6.54e-02
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 1.14e-01 1.88e-01 0.34200 -0.080500 -0.332000 6.15e-01 3.83e-02
TP53 Regulates Transcription of Cell Cycle Genes 47 2.22e-03 1.04e-02 0.34100 -0.221000 -0.260000 8.86e-03 2.02e-03
Mitotic Prometaphase 163 9.60e-11 3.83e-09 0.34100 -0.153000 -0.304000 7.54e-04 2.03e-11
Sensory processing of sound 66 2.03e-04 1.66e-03 0.34000 -0.225000 -0.255000 1.57e-03 3.34e-04
Regulation of FZD by ubiquitination 21 6.44e-02 1.23e-01 0.34000 -0.269000 -0.208000 3.28e-02 9.89e-02
Regulation of BACH1 activity 14 2.40e-02 6.01e-02 0.34000 -0.235000 0.245000 1.28e-01 1.12e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 1.60e-01 2.42e-01 0.33900 -0.273000 -0.201000 7.69e-02 1.92e-01
MAP kinase activation 56 6.89e-04 4.46e-03 0.33900 -0.270000 -0.205000 4.73e-04 7.88e-03
Degradation of cysteine and homocysteine 14 1.37e-01 2.16e-01 0.33900 -0.304000 -0.149000 4.86e-02 3.35e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 16 5.01e-02 1.03e-01 0.33900 -0.338000 -0.021900 1.92e-02 8.79e-01
Signaling by NOTCH2 31 1.55e-02 4.41e-02 0.33900 -0.178000 -0.288000 8.69e-02 5.49e-03
Effects of PIP2 hydrolysis 26 3.38e-02 7.72e-02 0.33800 -0.199000 -0.274000 7.92e-02 1.57e-02
Uptake and actions of bacterial toxins 29 2.08e-02 5.48e-02 0.33800 -0.287000 -0.179000 7.57e-03 9.55e-02
Signaling by FGFR2 in disease 41 1.07e-03 6.05e-03 0.33800 -0.069800 -0.330000 4.40e-01 2.53e-04
mTORC1-mediated signalling 18 5.77e-02 1.14e-01 0.33700 -0.092600 -0.324000 4.96e-01 1.72e-02
EML4 and NUDC in mitotic spindle formation 90 1.53e-06 2.54e-05 0.33700 -0.119000 -0.315000 5.20e-02 2.30e-07
Acetylcholine binding and downstream events 14 6.86e-02 1.29e-01 0.33600 0.004880 0.336000 9.75e-01 2.93e-02
Postsynaptic nicotinic acetylcholine receptors 14 6.86e-02 1.29e-01 0.33600 0.004880 0.336000 9.75e-01 2.93e-02
Phase 0 - rapid depolarisation 31 1.49e-02 4.29e-02 0.33600 -0.163000 -0.294000 1.17e-01 4.57e-03
RHOB GTPase cycle 60 2.83e-04 2.17e-03 0.33600 -0.159000 -0.296000 3.27e-02 7.43e-05
Interleukin-6 signaling 11 2.10e-01 2.94e-01 0.33600 -0.139000 -0.306000 4.25e-01 7.90e-02
Diseases of DNA repair 45 1.78e-03 9.03e-03 0.33500 -0.141000 -0.304000 1.02e-01 4.13e-04
Regulation of TNFR1 signaling 31 1.87e-02 5.09e-02 0.33500 -0.273000 -0.194000 8.51e-03 6.11e-02
mRNA decay by 5’ to 3’ exoribonuclease 15 1.52e-01 2.35e-01 0.33500 -0.214000 -0.257000 1.51e-01 8.46e-02
Retrograde neurotrophin signalling 14 1.55e-01 2.38e-01 0.33400 -0.167000 -0.290000 2.79e-01 6.06e-02
RUNX3 regulates NOTCH signaling 13 1.42e-01 2.22e-01 0.33400 -0.107000 -0.317000 5.02e-01 4.81e-02
Neurotransmitter release cycle 47 2.93e-03 1.30e-02 0.33400 -0.218000 -0.253000 9.71e-03 2.74e-03
Sensory perception of sweet, bitter, and umami (glutamate) taste 35 7.70e-03 2.69e-02 0.33300 0.140000 0.303000 1.53e-01 1.95e-03
Mitochondrial biogenesis 66 2.78e-04 2.15e-03 0.33300 -0.209000 -0.259000 3.35e-03 2.75e-04
Gap junction degradation 10 1.88e-01 2.71e-01 0.33200 -0.055300 -0.328000 7.62e-01 7.28e-02
Loss of Nlp from mitotic centrosomes 59 1.95e-04 1.63e-03 0.33200 -0.117000 -0.311000 1.21e-01 3.59e-05
Loss of proteins required for interphase microtubule organization from the centrosome 59 1.95e-04 1.63e-03 0.33200 -0.117000 -0.311000 1.21e-01 3.59e-05
CYP2E1 reactions 10 2.61e-01 3.50e-01 0.33200 0.152000 0.295000 4.04e-01 1.07e-01
Regulation of TP53 Expression and Degradation 37 1.10e-02 3.51e-02 0.33100 -0.219000 -0.248000 2.11e-02 9.08e-03
Death Receptor Signalling 119 4.16e-07 8.65e-06 0.33100 -0.199000 -0.264000 1.82e-04 6.24e-07
ERBB2 Regulates Cell Motility 15 9.14e-02 1.60e-01 0.33100 -0.323000 -0.070800 3.03e-02 6.35e-01
EPH-Ephrin signaling 89 1.46e-05 1.95e-04 0.33100 -0.189000 -0.272000 2.09e-03 9.50e-06
Passive transport by Aquaporins 13 1.95e-01 2.79e-01 0.33100 0.188000 0.272000 2.41e-01 8.95e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus 24 5.32e-02 1.07e-01 0.33000 -0.211000 -0.254000 7.40e-02 3.09e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 37 8.37e-03 2.88e-02 0.33000 -0.166000 -0.285000 7.97e-02 2.69e-03
MAP3K8 (TPL2)-dependent MAPK1/3 activation 15 1.20e-01 1.96e-01 0.33000 -0.307000 -0.122000 3.96e-02 4.15e-01
Recruitment of NuMA to mitotic centrosomes 67 9.43e-05 8.94e-04 0.33000 -0.130000 -0.303000 6.49e-02 1.79e-05
Formation of RNA Pol II elongation complex 49 3.48e-04 2.54e-03 0.33000 -0.059200 -0.324000 4.73e-01 8.56e-05
RNA Polymerase II Transcription Elongation 49 3.48e-04 2.54e-03 0.33000 -0.059200 -0.324000 4.73e-01 8.56e-05
Activation of the AP-1 family of transcription factors 10 2.72e-01 3.60e-01 0.32900 -0.159000 -0.288000 3.85e-01 1.15e-01
Processing and activation of SUMO 10 1.87e-01 2.70e-01 0.32900 -0.326000 -0.043600 7.43e-02 8.11e-01
TCF dependent signaling in response to WNT 167 1.47e-09 5.42e-08 0.32800 -0.192000 -0.266000 1.87e-05 3.08e-09
Signaling by FGFR4 in disease 11 2.47e-01 3.34e-01 0.32700 -0.162000 -0.283000 3.51e-01 1.04e-01
Synthesis of very long-chain fatty acyl-CoAs 18 1.16e-01 1.91e-01 0.32600 -0.202000 -0.256000 1.37e-01 6.03e-02
FGFRL1 modulation of FGFR1 signaling 13 1.91e-01 2.73e-01 0.32600 -0.284000 -0.159000 7.57e-02 3.20e-01
Diseases associated with N-glycosylation of proteins 19 6.58e-02 1.25e-01 0.32600 -0.103000 -0.309000 4.39e-01 1.97e-02
Activation of the pre-replicative complex 24 2.99e-02 7.04e-02 0.32600 -0.093500 -0.312000 4.28e-01 8.16e-03
Centrosome maturation 68 1.04e-04 9.55e-04 0.32600 -0.128000 -0.299000 6.78e-02 1.97e-05
Recruitment of mitotic centrosome proteins and complexes 68 1.04e-04 9.55e-04 0.32600 -0.128000 -0.299000 6.78e-02 1.97e-05
Signaling by ALK fusions and activated point mutants 51 7.42e-04 4.64e-03 0.32500 -0.106000 -0.307000 1.91e-01 1.47e-04
Signaling by ALK in cancer 51 7.42e-04 4.64e-03 0.32500 -0.106000 -0.307000 1.91e-01 1.47e-04
DNA Damage Bypass 45 5.26e-03 2.02e-02 0.32400 -0.235000 -0.224000 6.41e-03 9.47e-03
Elevation of cytosolic Ca2+ levels 16 1.52e-01 2.35e-01 0.32400 -0.204000 -0.251000 1.57e-01 8.16e-02
Degradation of beta-catenin by the destruction complex 81 1.48e-05 1.95e-04 0.32400 -0.114000 -0.303000 7.59e-02 2.42e-06
Inhibition of DNA recombination at telomere 20 5.92e-02 1.16e-01 0.32400 -0.102000 -0.307000 4.29e-01 1.74e-02
Defective B3GALTL causes PpS 34 1.19e-02 3.70e-02 0.32300 -0.138000 -0.293000 1.64e-01 3.15e-03
AURKA Activation by TPX2 62 3.39e-04 2.49e-03 0.32300 -0.143000 -0.290000 5.20e-02 7.72e-05
Intrinsic Pathway for Apoptosis 52 2.14e-03 1.02e-02 0.32300 -0.259000 -0.193000 1.24e-03 1.59e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 1.26e-02 3.82e-02 0.32200 -0.261000 -0.188000 5.94e-03 4.78e-02
FGFR2 mutant receptor activation 31 8.41e-03 2.89e-02 0.32200 -0.060000 -0.316000 5.63e-01 2.31e-03
Signaling by NTRK3 (TRKC) 16 8.06e-02 1.45e-01 0.32200 -0.050900 -0.318000 7.25e-01 2.79e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 15 1.30e-01 2.08e-01 0.32100 -0.113000 -0.301000 4.48e-01 4.36e-02
Drug ADME 89 3.57e-05 4.07e-04 0.32100 0.245000 0.207000 6.27e-05 7.24e-04
Sphingolipid de novo biosynthesis 33 1.61e-02 4.55e-02 0.32100 -0.284000 -0.150000 4.74e-03 1.36e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 81 1.00e-04 9.34e-04 0.32000 -0.226000 -0.227000 4.34e-04 4.11e-04
Pre-NOTCH Processing in Golgi 18 6.38e-02 1.23e-01 0.32000 -0.315000 -0.059600 2.08e-02 6.62e-01
Impaired BRCA2 binding to RAD51 31 1.41e-02 4.17e-02 0.32000 -0.104000 -0.303000 3.15e-01 3.51e-03
G-protein mediated events 51 2.10e-03 1.01e-02 0.32000 -0.164000 -0.275000 4.27e-02 6.83e-04
Downstream signaling of activated FGFR3 24 5.55e-02 1.11e-01 0.32000 -0.167000 -0.273000 1.58e-01 2.05e-02
MyD88 dependent cascade initiated on endosome 82 9.33e-05 8.91e-04 0.32000 -0.220000 -0.232000 5.82e-04 2.79e-04
Toll Like Receptor 7/8 (TLR7/8) Cascade 82 9.33e-05 8.91e-04 0.32000 -0.220000 -0.232000 5.82e-04 2.79e-04
Amino acid transport across the plasma membrane 30 4.11e-03 1.68e-02 0.31900 -0.318000 0.023800 2.54e-03 8.21e-01
Regulation of signaling by CBL 18 2.46e-02 6.07e-02 0.31900 0.086900 -0.307000 5.23e-01 2.41e-02
Translesion synthesis by POLK 17 1.47e-01 2.28e-01 0.31700 -0.245000 -0.202000 8.06e-02 1.49e-01
Vpr-mediated nuclear import of PICs 31 2.68e-02 6.51e-02 0.31700 -0.173000 -0.266000 9.46e-02 1.05e-02
RAF activation 33 2.19e-02 5.66e-02 0.31700 -0.179000 -0.262000 7.54e-02 9.20e-03
Interactions of Vpr with host cellular proteins 32 2.40e-02 6.01e-02 0.31700 -0.172000 -0.266000 9.26e-02 9.19e-03
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 3.07e-01 3.98e-01 0.31700 -0.270000 -0.164000 1.39e-01 3.68e-01
RHOV GTPase cycle 34 1.44e-02 4.21e-02 0.31600 -0.134000 -0.286000 1.76e-01 3.85e-03
Opioid Signalling 87 5.50e-05 5.76e-04 0.31600 -0.192000 -0.251000 2.00e-03 5.03e-05
Transcription of the HIV genome 58 1.76e-04 1.50e-03 0.31600 -0.057000 -0.311000 4.53e-01 4.25e-05
Phospholipase C-mediated cascade; FGFR3 12 2.55e-01 3.42e-01 0.31500 -0.258000 -0.181000 1.21e-01 2.77e-01
DSCAM interactions 11 2.77e-01 3.64e-01 0.31500 -0.166000 -0.268000 3.40e-01 1.24e-01
HDR through Single Strand Annealing (SSA) 34 7.43e-03 2.62e-02 0.31500 -0.068600 -0.307000 4.89e-01 1.92e-03
Metabolism of cofactors 19 1.20e-01 1.96e-01 0.31500 -0.194000 -0.248000 1.44e-01 6.15e-02
Signaling by WNT 257 2.06e-13 1.25e-11 0.31400 -0.170000 -0.264000 2.72e-06 3.01e-13
Platelet homeostasis 85 5.31e-05 5.60e-04 0.31400 -0.162000 -0.269000 9.68e-03 1.85e-05
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 25 6.52e-02 1.25e-01 0.31400 -0.226000 -0.217000 5.03e-02 5.99e-02
RNA Polymerase III Transcription Initiation 36 1.33e-02 3.98e-02 0.31400 -0.143000 -0.279000 1.37e-01 3.77e-03
Ras activation upon Ca2+ influx through NMDA receptor 19 1.16e-01 1.91e-01 0.31300 -0.173000 -0.261000 1.91e-01 4.89e-02
Regulation of TP53 Degradation 36 1.93e-02 5.21e-02 0.31300 -0.202000 -0.239000 3.56e-02 1.30e-02
Transcriptional regulation of pluripotent stem cells 29 2.09e-02 5.48e-02 0.31300 -0.095400 -0.298000 3.74e-01 5.44e-03
Diseases of signal transduction by growth factor receptors and second messengers 404 1.99e-21 2.32e-19 0.31300 -0.141000 -0.279000 1.18e-06 5.78e-22
Anchoring of the basal body to the plasma membrane 83 1.70e-05 2.21e-04 0.31300 -0.096800 -0.297000 1.28e-01 2.80e-06
Voltage gated Potassium channels 42 1.01e-02 3.31e-02 0.31300 -0.240000 -0.200000 7.04e-03 2.49e-02
Phospholipase C-mediated cascade: FGFR1 16 1.26e-01 2.03e-01 0.31200 -0.294000 -0.105000 4.18e-02 4.67e-01
VEGFR2 mediated vascular permeability 26 3.77e-02 8.19e-02 0.31200 -0.116000 -0.290000 3.06e-01 1.06e-02
Zinc transporters 17 1.13e-01 1.88e-01 0.31200 -0.292000 -0.109000 3.70e-02 4.35e-01
PI-3K cascade:FGFR3 17 1.51e-01 2.33e-01 0.31100 -0.175000 -0.257000 2.12e-01 6.65e-02
Mitochondrial tRNA aminoacylation 18 5.83e-02 1.15e-01 0.31100 -0.019100 -0.310000 8.88e-01 2.27e-02
Signaling by Leptin 11 2.75e-01 3.63e-01 0.31000 -0.275000 -0.143000 1.14e-01 4.12e-01
IRAK4 deficiency (TLR2/4) 17 1.39e-01 2.19e-01 0.30900 0.144000 0.273000 3.03e-01 5.11e-02
ER Quality Control Compartment (ERQC) 20 8.40e-02 1.50e-01 0.30900 -0.287000 -0.114000 2.62e-02 3.79e-01
Nuclear Receptor transcription pathway 51 3.68e-03 1.53e-02 0.30800 -0.257000 -0.170000 1.47e-03 3.62e-02
Syndecan interactions 19 8.74e-02 1.54e-01 0.30800 -0.095900 -0.293000 4.69e-01 2.73e-02
Transcriptional regulation by RUNX3 93 1.04e-05 1.45e-04 0.30800 -0.111000 -0.287000 6.55e-02 1.70e-06
Androgen biosynthesis 11 3.16e-01 4.07e-01 0.30700 0.219000 0.215000 2.08e-01 2.17e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 4.98e-02 1.03e-01 0.30700 -0.181000 -0.248000 9.66e-02 2.34e-02
Mitotic Spindle Checkpoint 101 7.78e-06 1.14e-04 0.30600 -0.131000 -0.277000 2.28e-02 1.52e-06
Suppression of phagosomal maturation 13 1.57e-01 2.40e-01 0.30600 -0.302000 -0.048200 5.94e-02 7.63e-01
Chromatin modifying enzymes 167 2.31e-09 7.97e-08 0.30600 -0.118000 -0.282000 8.56e-03 3.17e-10
Chromatin organization 167 2.31e-09 7.97e-08 0.30600 -0.118000 -0.282000 8.56e-03 3.17e-10
GPER1 signaling 42 1.28e-02 3.86e-02 0.30600 -0.223000 -0.209000 1.22e-02 1.93e-02
Calnexin/calreticulin cycle 25 4.33e-02 9.19e-02 0.30500 -0.290000 -0.097000 1.22e-02 4.01e-01
Signaling by VEGF 100 7.48e-06 1.10e-04 0.30500 -0.121000 -0.280000 3.67e-02 1.30e-06
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 12 2.49e-01 3.35e-01 0.30300 -0.124000 -0.277000 4.58e-01 9.70e-02
Regulation of PLK1 Activity at G2/M Transition 75 1.73e-04 1.48e-03 0.30300 -0.124000 -0.276000 6.39e-02 3.47e-05
Circadian Clock 67 1.06e-03 6.02e-03 0.30300 -0.196000 -0.231000 5.45e-03 1.10e-03
Chromosome Maintenance 78 1.06e-04 9.68e-04 0.30300 -0.116000 -0.280000 7.55e-02 1.97e-05
Leading Strand Synthesis 13 1.60e-01 2.42e-01 0.30300 -0.043600 -0.300000 7.85e-01 6.14e-02
Polymerase switching 13 1.60e-01 2.42e-01 0.30300 -0.043600 -0.300000 7.85e-01 6.14e-02
Class C/3 (Metabotropic glutamate/pheromone receptors) 31 4.14e-02 8.85e-02 0.30300 0.192000 0.234000 6.44e-02 2.41e-02
Heme biosynthesis 13 2.68e-01 3.58e-01 0.30200 -0.217000 -0.210000 1.76e-01 1.90e-01
Toll Like Receptor 3 (TLR3) Cascade 86 1.67e-04 1.45e-03 0.30200 -0.201000 -0.225000 1.24e-03 3.16e-04
Inositol phosphate metabolism 43 5.33e-03 2.03e-02 0.30200 -0.098300 -0.285000 2.65e-01 1.21e-03
Fatty acyl-CoA biosynthesis 30 3.11e-02 7.27e-02 0.30200 -0.119000 -0.277000 2.58e-01 8.67e-03
Downstream signaling of activated FGFR4 26 4.39e-02 9.29e-02 0.30100 -0.103000 -0.283000 3.63e-01 1.24e-02
VEGFA-VEGFR2 Pathway 92 4.76e-05 5.13e-04 0.30100 -0.148000 -0.262000 1.40e-02 1.37e-05
ESR-mediated signaling 154 9.30e-08 2.43e-06 0.30100 -0.161000 -0.254000 5.48e-04 5.20e-08
Interleukin-27 signaling 11 2.76e-01 3.64e-01 0.30100 -0.113000 -0.279000 5.16e-01 1.09e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 15 1.98e-01 2.81e-01 0.30100 0.261000 0.150000 8.01e-02 3.15e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 34 2.09e-02 5.48e-02 0.30000 -0.274000 -0.123000 5.67e-03 2.16e-01
O-glycosylation of TSR domain-containing proteins 35 2.13e-02 5.55e-02 0.30000 -0.137000 -0.267000 1.62e-01 6.25e-03
Signaling by NOTCH4 79 4.42e-05 4.79e-04 0.30000 -0.075500 -0.290000 2.46e-01 8.27e-06
Viral Messenger RNA Synthesis 41 6.27e-03 2.29e-02 0.30000 -0.085900 -0.287000 3.41e-01 1.47e-03
Synthesis of IP3 and IP4 in the cytosol 25 2.80e-02 6.72e-02 0.30000 -0.028600 -0.298000 8.04e-01 9.87e-03
mRNA 3’-end processing 41 8.92e-03 3.03e-02 0.29900 -0.113000 -0.277000 2.10e-01 2.17e-03
RND2 GTPase cycle 40 1.42e-02 4.18e-02 0.29900 -0.148000 -0.259000 1.04e-01 4.53e-03
Diseases associated with glycosaminoglycan metabolism 36 1.92e-02 5.19e-02 0.29900 -0.268000 -0.133000 5.45e-03 1.68e-01
tRNA processing in the nucleus 53 4.36e-03 1.76e-02 0.29800 -0.167000 -0.247000 3.52e-02 1.85e-03
Miscellaneous substrates 12 1.77e-01 2.61e-01 0.29800 0.021700 0.298000 8.97e-01 7.43e-02
tRNA Aminoacylation 24 3.97e-02 8.55e-02 0.29800 -0.047900 -0.294000 6.85e-01 1.27e-02
Signaling by FGFR in disease 59 2.36e-03 1.10e-02 0.29800 -0.162000 -0.249000 3.09e-02 9.29e-04
Sensory perception of taste 41 2.77e-03 1.24e-02 0.29700 0.020600 0.297000 8.20e-01 1.01e-03
Nervous system development 519 1.17e-24 1.98e-22 0.29700 -0.132000 -0.266000 2.94e-07 3.22e-25
Organelle biogenesis and maintenance 225 2.18e-11 1.00e-09 0.29700 -0.125000 -0.269000 1.24e-03 3.52e-12
InlB-mediated entry of Listeria monocytogenes into host cell 14 2.33e-01 3.21e-01 0.29700 -0.255000 -0.151000 9.83e-02 3.27e-01
Downstream signaling of activated FGFR2 28 5.46e-02 1.09e-01 0.29700 -0.152000 -0.255000 1.64e-01 1.97e-02
Synthesis of IP2, IP, and Ins in the cytosol 13 2.63e-01 3.52e-01 0.29600 -0.251000 -0.157000 1.17e-01 3.28e-01
Translesion Synthesis by POLH 18 1.44e-01 2.25e-01 0.29600 -0.265000 -0.131000 5.19e-02 3.34e-01
RNA Polymerase II Pre-transcription Events 69 1.40e-04 1.25e-03 0.29600 -0.058600 -0.290000 4.00e-01 3.17e-05
Postmitotic nuclear pore complex (NPC) reformation 25 6.22e-02 1.21e-01 0.29500 -0.115000 -0.271000 3.19e-01 1.88e-02
HIV Life Cycle 131 1.06e-06 1.87e-05 0.29500 -0.138000 -0.261000 6.48e-03 2.56e-07
Triglyceride catabolism 19 1.48e-01 2.29e-01 0.29500 -0.246000 -0.162000 6.33e-02 2.20e-01
Listeria monocytogenes entry into host cells 19 1.58e-01 2.41e-01 0.29500 -0.224000 -0.192000 9.08e-02 1.48e-01
Transport of Mature Transcript to Cytoplasm 63 1.52e-03 7.96e-03 0.29500 -0.149000 -0.255000 4.14e-02 4.74e-04
RNA Polymerase II Transcription Termination 50 3.00e-03 1.31e-02 0.29500 -0.095700 -0.279000 2.42e-01 6.53e-04
Mitotic G1 phase and G1/S transition 137 6.87e-07 1.36e-05 0.29500 -0.143000 -0.257000 3.83e-03 1.96e-07
FOXO-mediated transcription of cell death genes 15 1.98e-01 2.81e-01 0.29400 -0.125000 -0.266000 4.03e-01 7.40e-02
Diseases associated with visual transduction 11 1.88e-01 2.71e-01 0.29400 0.293000 -0.013500 9.22e-02 9.38e-01
Diseases of the neuronal system 11 1.88e-01 2.71e-01 0.29400 0.293000 -0.013500 9.22e-02 9.38e-01
Retinoid cycle disease events 11 1.88e-01 2.71e-01 0.29400 0.293000 -0.013500 9.22e-02 9.38e-01
Depolymerisation of the Nuclear Lamina 12 2.54e-01 3.41e-01 0.29300 -0.099500 -0.276000 5.51e-01 9.79e-02
Insulin processing 24 9.51e-02 1.64e-01 0.29300 -0.172000 -0.238000 1.46e-01 4.37e-02
Regulation of KIT signaling 16 1.31e-01 2.08e-01 0.29300 -0.055700 -0.287000 7.00e-01 4.67e-02
Cardiac conduction 120 1.20e-05 1.62e-04 0.29200 -0.195000 -0.217000 2.29e-04 3.92e-05
Downregulation of ERBB2 signaling 28 1.88e-02 5.09e-02 0.29200 -0.292000 -0.009800 7.55e-03 9.28e-01
Transcriptional regulation by small RNAs 43 7.05e-03 2.51e-02 0.29100 -0.089500 -0.277000 3.10e-01 1.65e-03
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 44 1.02e-02 3.31e-02 0.29100 -0.130000 -0.261000 1.37e-01 2.76e-03
Signaling by FGFR3 in disease 21 1.27e-01 2.04e-01 0.29100 -0.160000 -0.243000 2.05e-01 5.35e-02
ZBP1(DAI) mediated induction of type I IFNs 20 1.11e-01 1.85e-01 0.29100 -0.107000 -0.271000 4.07e-01 3.62e-02
Axon guidance 497 6.63e-23 8.39e-21 0.29100 -0.126000 -0.262000 1.53e-06 1.39e-23
HATs acetylate histones 59 2.50e-04 1.96e-03 0.29100 -0.010100 -0.290000 8.93e-01 1.14e-04
Adrenaline,noradrenaline inhibits insulin secretion 28 7.17e-02 1.32e-01 0.29000 -0.189000 -0.220000 8.29e-02 4.37e-02
Toll Like Receptor 9 (TLR9) Cascade 85 3.65e-04 2.64e-03 0.29000 -0.201000 -0.209000 1.37e-03 8.55e-04
MyD88-independent TLR4 cascade 90 2.40e-04 1.90e-03 0.28900 -0.195000 -0.214000 1.42e-03 4.59e-04
TRIF(TICAM1)-mediated TLR4 signaling 90 2.40e-04 1.90e-03 0.28900 -0.195000 -0.214000 1.42e-03 4.59e-04
Paracetamol ADME 29 6.75e-02 1.27e-01 0.28900 0.191000 0.217000 7.53e-02 4.33e-02
RHOU GTPase cycle 35 1.53e-02 4.39e-02 0.28900 -0.068100 -0.280000 4.86e-01 4.08e-03
HDR through Homologous Recombination (HRR) 58 4.69e-03 1.87e-02 0.28800 -0.214000 -0.193000 4.79e-03 1.09e-02
SUMOylation of DNA methylation proteins 16 2.13e-01 2.97e-01 0.28800 -0.243000 -0.156000 9.30e-02 2.80e-01
APC/C:Cdc20 mediated degradation of Cyclin B 22 3.02e-02 7.09e-02 0.28800 -0.284000 0.050800 2.12e-02 6.80e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 35 2.33e-02 5.91e-02 0.28800 -0.108000 -0.267000 2.71e-01 6.20e-03
Diseases of DNA Double-Strand Break Repair 35 2.33e-02 5.91e-02 0.28800 -0.108000 -0.267000 2.71e-01 6.20e-03
ERBB2 Activates PTK6 Signaling 13 1.29e-01 2.07e-01 0.28800 -0.284000 0.045500 7.57e-02 7.76e-01
Signaling by FGFR1 in disease 36 3.65e-02 8.03e-02 0.28800 -0.199000 -0.208000 3.83e-02 3.11e-02
Nucleotide biosynthesis 14 2.46e-01 3.33e-01 0.28800 -0.254000 -0.136000 1.00e-01 3.77e-01
Synthesis of PIPs at the plasma membrane 47 1.32e-02 3.96e-02 0.28800 -0.193000 -0.214000 2.23e-02 1.12e-02
Termination of translesion DNA synthesis 31 5.65e-02 1.12e-01 0.28800 -0.221000 -0.185000 3.34e-02 7.51e-02
Transcriptional activation of mitochondrial biogenesis 48 1.16e-02 3.64e-02 0.28800 -0.182000 -0.223000 2.91e-02 7.54e-03
G1/S Transition 119 3.80e-06 5.95e-05 0.28800 -0.114000 -0.264000 3.14e-02 6.46e-07
Non-integrin membrane-ECM interactions 40 6.84e-03 2.45e-02 0.28800 -0.049000 -0.283000 5.92e-01 1.92e-03
Late Phase of HIV Life Cycle 118 8.96e-06 1.30e-04 0.28700 -0.139000 -0.251000 9.03e-03 2.47e-06
Export of Viral Ribonucleoproteins from Nucleus 30 6.15e-02 1.20e-01 0.28700 -0.175000 -0.227000 9.66e-02 3.12e-02
Neuronal System 369 4.06e-15 2.68e-13 0.28700 -0.204000 -0.201000 1.57e-11 3.30e-11
G alpha (12/13) signalling events 68 6.73e-04 4.39e-03 0.28700 -0.102000 -0.268000 1.46e-01 1.33e-04
PLC beta mediated events 47 1.03e-02 3.33e-02 0.28600 -0.144000 -0.248000 8.71e-02 3.33e-03
Lysosome Vesicle Biogenesis 33 4.57e-02 9.58e-02 0.28600 -0.232000 -0.168000 2.10e-02 9.55e-02
PI3K events in ERBB4 signaling 10 3.70e-01 4.60e-01 0.28600 -0.253000 -0.134000 1.66e-01 4.64e-01
Signaling by cytosolic FGFR1 fusion mutants 16 2.30e-01 3.17e-01 0.28600 -0.222000 -0.181000 1.24e-01 2.11e-01
SUMOylation of chromatin organization proteins 53 8.02e-03 2.78e-02 0.28600 -0.213000 -0.191000 7.23e-03 1.63e-02
PI-3K cascade:FGFR4 19 1.21e-01 1.97e-01 0.28600 -0.087100 -0.272000 5.11e-01 3.99e-02
Cilium Assembly 159 2.60e-08 7.46e-07 0.28600 -0.089200 -0.272000 5.23e-02 3.46e-09
PI-3K cascade:FGFR1 21 1.47e-01 2.28e-01 0.28600 -0.218000 -0.185000 8.37e-02 1.43e-01
Kinesins 42 1.98e-02 5.31e-02 0.28600 -0.165000 -0.234000 6.49e-02 8.83e-03
Cell Cycle Checkpoints 233 4.02e-11 1.78e-09 0.28600 -0.114000 -0.262000 2.81e-03 5.51e-12
Interaction between L1 and Ankyrins 28 1.42e-02 4.18e-02 0.28600 0.037600 -0.283000 7.31e-01 9.51e-03
Beta-catenin independent WNT signaling 140 4.02e-07 8.59e-06 0.28600 -0.106000 -0.265000 3.11e-02 5.95e-08
Transport of Ribonucleoproteins into the Host Nucleus 29 6.87e-02 1.29e-01 0.28500 -0.171000 -0.229000 1.11e-01 3.32e-02
STAT5 activation downstream of FLT3 ITD mutants 10 4.03e-01 4.93e-01 0.28500 -0.218000 -0.183000 2.32e-01 3.16e-01
Glucagon signaling in metabolic regulation 32 5.67e-02 1.12e-01 0.28400 -0.210000 -0.191000 4.00e-02 6.09e-02
TGF-beta receptor signaling activates SMADs 45 1.82e-02 5.01e-02 0.28300 -0.205000 -0.196000 1.75e-02 2.31e-02
Incretin synthesis, secretion, and inactivation 20 9.77e-02 1.68e-01 0.28300 -0.060900 -0.276000 6.37e-01 3.26e-02
Cellular Senescence 122 2.00e-05 2.49e-04 0.28200 -0.214000 -0.184000 4.42e-05 4.40e-04
Ephrin signaling 17 1.86e-01 2.70e-01 0.28200 -0.122000 -0.254000 3.82e-01 6.95e-02
Activation of GABAB receptors 42 2.39e-02 6.00e-02 0.28200 -0.215000 -0.183000 1.60e-02 4.02e-02
GABA B receptor activation 42 2.39e-02 6.00e-02 0.28200 -0.215000 -0.183000 1.60e-02 4.02e-02
Rev-mediated nuclear export of HIV RNA 32 4.85e-02 1.01e-01 0.28200 -0.142000 -0.244000 1.65e-01 1.70e-02
Signaling by ERBB2 49 1.13e-02 3.58e-02 0.28200 -0.233000 -0.159000 4.76e-03 5.43e-02
Downregulation of TGF-beta receptor signaling 26 6.89e-02 1.29e-01 0.28200 -0.262000 -0.106000 2.09e-02 3.52e-01
Cargo trafficking to the periciliary membrane 48 5.84e-03 2.20e-02 0.28200 -0.088200 -0.267000 2.90e-01 1.34e-03
Interleukin-17 signaling 64 3.13e-03 1.33e-02 0.28200 -0.228000 -0.166000 1.64e-03 2.18e-02
Signaling by TGF-beta Receptor Complex 86 3.58e-04 2.60e-03 0.28100 -0.149000 -0.239000 1.70e-02 1.32e-04
PI-3K cascade:FGFR2 21 1.46e-01 2.28e-01 0.28100 -0.154000 -0.235000 2.22e-01 6.20e-02
Mitochondrial protein import 48 4.47e-04 3.10e-03 0.28100 0.080600 -0.269000 3.34e-01 1.25e-03
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 24 1.17e-01 1.93e-01 0.28100 0.224000 0.170000 5.80e-02 1.49e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 2.78e-01 3.64e-01 0.28100 -0.235000 -0.154000 1.28e-01 3.20e-01
Metal ion SLC transporters 25 9.81e-02 1.68e-01 0.28100 -0.240000 -0.145000 3.75e-02 2.10e-01
Activation of kainate receptors upon glutamate binding 29 6.33e-02 1.22e-01 0.28100 -0.133000 -0.247000 2.17e-01 2.12e-02
Transport of the SLBP Dependant Mature mRNA 32 4.54e-02 9.52e-02 0.28000 -0.126000 -0.251000 2.19e-01 1.41e-02
SUMO E3 ligases SUMOylate target proteins 157 1.19e-06 2.07e-05 0.28000 -0.189000 -0.207000 4.53e-05 7.28e-06
Interactions of Rev with host cellular proteins 34 4.66e-02 9.74e-02 0.28000 -0.158000 -0.231000 1.10e-01 1.97e-02
HIV Transcription Initiation 43 6.29e-03 2.29e-02 0.28000 -0.047700 -0.276000 5.88e-01 1.76e-03
RNA Polymerase II HIV Promoter Escape 43 6.29e-03 2.29e-02 0.28000 -0.047700 -0.276000 5.88e-01 1.76e-03
RNA Polymerase II Promoter Escape 43 6.29e-03 2.29e-02 0.28000 -0.047700 -0.276000 5.88e-01 1.76e-03
RNA Polymerase II Transcription Initiation 43 6.29e-03 2.29e-02 0.28000 -0.047700 -0.276000 5.88e-01 1.76e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance 43 6.29e-03 2.29e-02 0.28000 -0.047700 -0.276000 5.88e-01 1.76e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 43 6.29e-03 2.29e-02 0.28000 -0.047700 -0.276000 5.88e-01 1.76e-03
XBP1(S) activates chaperone genes 47 1.45e-02 4.21e-02 0.27900 -0.155000 -0.233000 6.68e-02 5.81e-03
HCMV Early Events 54 7.48e-03 2.63e-02 0.27900 -0.150000 -0.236000 5.72e-02 2.76e-03
Methylation 14 1.89e-01 2.71e-01 0.27900 -0.276000 -0.041700 7.42e-02 7.87e-01
Transcriptional regulation of white adipocyte differentiation 78 7.75e-04 4.72e-03 0.27800 -0.140000 -0.241000 3.23e-02 2.39e-04
RHOA GTPase cycle 127 5.62e-06 8.53e-05 0.27800 -0.123000 -0.250000 1.67e-02 1.16e-06
SUMOylation 163 8.93e-07 1.63e-05 0.27800 -0.195000 -0.198000 1.68e-05 1.25e-05
DNA Double-Strand Break Repair 121 1.99e-05 2.49e-04 0.27800 -0.150000 -0.234000 4.49e-03 8.74e-06
TP53 Regulates Metabolic Genes 71 2.03e-03 9.95e-03 0.27700 -0.165000 -0.223000 1.65e-02 1.14e-03
Retrograde transport at the Trans-Golgi-Network 45 7.62e-03 2.67e-02 0.27700 -0.071600 -0.268000 4.06e-01 1.86e-03
TRAF6 mediated NF-kB activation 24 7.95e-02 1.43e-01 0.27700 -0.081500 -0.265000 4.90e-01 2.46e-02
Antigen processing: Ubiquitination & Proteasome degradation 285 1.17e-11 5.74e-10 0.27700 -0.148000 -0.234000 1.66e-05 1.13e-11
Presynaptic phase of homologous DNA pairing and strand exchange 34 3.07e-02 7.19e-02 0.27600 -0.089000 -0.262000 3.69e-01 8.30e-03
Ub-specific processing proteases 150 7.17e-07 1.39e-05 0.27600 -0.118000 -0.249000 1.24e-02 1.34e-07
Pregnenolone biosynthesis 10 1.75e-01 2.60e-01 0.27600 -0.168000 0.219000 3.58e-01 2.30e-01
FGFR3 ligand binding and activation 12 2.45e-01 3.33e-01 0.27500 -0.272000 -0.036500 1.02e-01 8.27e-01
FGFR3c ligand binding and activation 12 2.45e-01 3.33e-01 0.27500 -0.272000 -0.036500 1.02e-01 8.27e-01
Potassium Channels 102 1.53e-04 1.35e-03 0.27500 -0.225000 -0.158000 8.60e-05 5.97e-03
Unwinding of DNA 11 2.34e-01 3.22e-01 0.27400 0.011300 -0.274000 9.48e-01 1.16e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 1.45e-01 2.26e-01 0.27400 -0.232000 -0.146000 5.97e-02 2.36e-01
FGFR1 mutant receptor activation 29 8.99e-02 1.58e-01 0.27400 -0.192000 -0.195000 7.36e-02 6.91e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 86 7.17e-04 4.52e-03 0.27300 -0.167000 -0.217000 7.58e-03 5.12e-04
Negative epigenetic regulation of rRNA expression 45 2.21e-02 5.68e-02 0.27300 -0.162000 -0.220000 5.98e-02 1.07e-02
Diseases of programmed cell death 40 2.56e-02 6.25e-02 0.27300 -0.122000 -0.244000 1.83e-01 7.48e-03
Caspase-mediated cleavage of cytoskeletal proteins 11 3.72e-01 4.62e-01 0.27300 -0.131000 -0.239000 4.52e-01 1.69e-01
Transport of the SLBP independent Mature mRNA 31 6.26e-02 1.21e-01 0.27300 -0.132000 -0.239000 2.05e-01 2.13e-02
HCMV Infection 75 2.12e-03 1.02e-02 0.27200 -0.195000 -0.190000 3.50e-03 4.44e-03
FCGR3A-mediated phagocytosis 56 9.75e-03 3.23e-02 0.27200 -0.176000 -0.207000 2.26e-02 7.24e-03
Leishmania phagocytosis 56 9.75e-03 3.23e-02 0.27200 -0.176000 -0.207000 2.26e-02 7.24e-03
Parasite infection 56 9.75e-03 3.23e-02 0.27200 -0.176000 -0.207000 2.26e-02 7.24e-03
Oncogenic MAPK signaling 75 4.61e-04 3.15e-03 0.27200 -0.076300 -0.261000 2.53e-01 9.14e-05
Cell Cycle, Mitotic 448 2.73e-17 2.07e-15 0.27200 -0.142000 -0.232000 2.62e-07 4.11e-17
Separation of Sister Chromatids 156 4.10e-07 8.64e-06 0.27200 -0.104000 -0.251000 2.54e-02 6.25e-08
Telomere C-strand (Lagging Strand) Synthesis 30 7.21e-02 1.32e-01 0.27100 -0.136000 -0.235000 1.99e-01 2.58e-02
Termination of O-glycan biosynthesis 22 1.66e-01 2.48e-01 0.27100 0.194000 0.189000 1.14e-01 1.25e-01
Cyclin D associated events in G1 46 1.84e-02 5.03e-02 0.27100 -0.233000 -0.138000 6.24e-03 1.04e-01
G1 Phase 46 1.84e-02 5.03e-02 0.27100 -0.233000 -0.138000 6.24e-03 1.04e-01
RNA polymerase II transcribes snRNA genes 71 5.39e-04 3.60e-03 0.27100 -0.060700 -0.264000 3.76e-01 1.19e-04
tRNA processing 90 2.03e-04 1.66e-03 0.27100 -0.102000 -0.251000 9.55e-02 3.84e-05
Phospholipase C-mediated cascade; FGFR2 16 2.68e-01 3.58e-01 0.27100 -0.210000 -0.171000 1.47e-01 2.35e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 17 1.73e-01 2.57e-01 0.27100 -0.070700 -0.261000 6.14e-01 6.21e-02
FGFR1 ligand binding and activation 15 2.03e-01 2.86e-01 0.27100 -0.264000 -0.059400 7.66e-02 6.91e-01
Sodium/Calcium exchangers 10 2.41e-01 3.29e-01 0.27000 0.056000 -0.264000 7.59e-01 1.48e-01
Mitotic Prophase 75 2.19e-03 1.03e-02 0.27000 -0.170000 -0.210000 1.11e-02 1.66e-03
Ketone body metabolism 10 1.91e-01 2.73e-01 0.27000 0.222000 -0.154000 2.24e-01 4.00e-01
Signaling by ERBB2 ECD mutants 15 2.69e-01 3.58e-01 0.26900 -0.128000 -0.237000 3.91e-01 1.12e-01
Homologous DNA Pairing and Strand Exchange 37 3.31e-02 7.60e-02 0.26900 -0.106000 -0.247000 2.66e-01 9.28e-03
Elastic fibre formation 41 2.55e-02 6.25e-02 0.26900 -0.117000 -0.242000 1.97e-01 7.31e-03
Chylomicron assembly 10 2.84e-01 3.71e-01 0.26800 -0.007900 0.268000 9.66e-01 1.42e-01
Signaling by Receptor Tyrosine Kinases 484 4.04e-18 3.41e-16 0.26800 -0.141000 -0.228000 1.13e-07 7.44e-18
CDC42 GTPase cycle 132 1.68e-05 2.19e-04 0.26800 -0.144000 -0.226000 4.30e-03 7.32e-06
M Phase 316 4.49e-12 2.27e-10 0.26800 -0.143000 -0.226000 1.19e-05 4.50e-12
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 1.25e-01 2.02e-01 0.26800 -0.267000 -0.022000 5.00e-02 8.72e-01
RIP-mediated NFkB activation via ZBP1 16 2.56e-01 3.43e-01 0.26800 -0.134000 -0.232000 3.55e-01 1.08e-01
NEP/NS2 Interacts with the Cellular Export Machinery 29 9.33e-02 1.62e-01 0.26800 -0.155000 -0.218000 1.49e-01 4.20e-02
Defective pyroptosis 11 3.68e-01 4.59e-01 0.26700 -0.107000 -0.245000 5.39e-01 1.59e-01
RHOD GTPase cycle 45 2.77e-02 6.67e-02 0.26700 -0.172000 -0.204000 4.60e-02 1.76e-02
Transcriptional Regulation by TP53 321 4.35e-12 2.27e-10 0.26700 -0.146000 -0.224000 7.17e-06 5.82e-12
Vasopressin regulates renal water homeostasis via Aquaporins 42 2.93e-02 6.97e-02 0.26700 -0.229000 -0.136000 1.01e-02 1.27e-01
Cyclin A/B1/B2 associated events during G2/M transition 24 8.54e-02 1.52e-01 0.26600 -0.059600 -0.259000 6.13e-01 2.78e-02
Extra-nuclear estrogen signaling 71 3.48e-03 1.46e-02 0.26600 -0.162000 -0.211000 1.80e-02 2.15e-03
RHOJ GTPase cycle 48 7.98e-03 2.77e-02 0.26600 -0.064400 -0.258000 4.40e-01 2.00e-03
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 578 3.60e-21 3.65e-19 0.26600 -0.135000 -0.229000 3.08e-08 5.43e-21
Negative regulators of DDX58/IFIH1 signaling 34 6.39e-02 1.23e-01 0.26500 -0.218000 -0.151000 2.76e-02 1.28e-01
DNA Repair 262 6.65e-10 2.52e-08 0.26500 -0.146000 -0.222000 4.95e-05 6.50e-10
Heme degradation 16 2.73e-01 3.62e-01 0.26500 0.148000 0.220000 3.05e-01 1.28e-01
Recycling pathway of L1 22 1.77e-01 2.61e-01 0.26400 -0.160000 -0.210000 1.93e-01 8.87e-02
WNT5A-dependent internalization of FZD4 15 1.05e-01 1.78e-01 0.26300 0.111000 -0.238000 4.56e-01 1.10e-01
Intraflagellar transport 32 6.58e-02 1.25e-01 0.26300 -0.117000 -0.235000 2.52e-01 2.12e-02
Regulation of TP53 Activity 149 1.10e-05 1.50e-04 0.26300 -0.172000 -0.199000 2.95e-04 2.79e-05
Activation of Matrix Metalloproteinases 29 4.90e-02 1.01e-01 0.26300 0.044700 0.259000 6.77e-01 1.58e-02
Negative regulation of FGFR1 signaling 32 2.42e-02 6.01e-02 0.26300 -0.263000 -0.004310 1.02e-02 9.66e-01
Signaling by ERBB2 KD Mutants 24 1.59e-01 2.41e-01 0.26200 -0.176000 -0.195000 1.35e-01 9.89e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs 67 4.50e-03 1.80e-02 0.26200 -0.138000 -0.223000 5.14e-02 1.56e-03
Signal regulatory protein family interactions 13 1.56e-01 2.39e-01 0.26200 -0.084800 0.248000 5.96e-01 1.21e-01
Telomere Maintenance 59 5.17e-03 2.00e-02 0.26200 -0.095900 -0.244000 2.03e-01 1.19e-03
Signaling by Rho GTPases 564 4.76e-20 4.52e-18 0.26100 -0.133000 -0.225000 7.13e-08 6.37e-20
Recognition of DNA damage by PCNA-containing replication complex 29 1.09e-01 1.83e-01 0.26100 -0.161000 -0.205000 1.34e-01 5.60e-02
MAPK3 (ERK1) activation 10 4.00e-01 4.91e-01 0.26000 -0.081900 -0.247000 6.54e-01 1.76e-01
L1CAM interactions 91 2.83e-04 2.17e-03 0.26000 -0.087900 -0.245000 1.47e-01 5.30e-05
RHO GTPases activate CIT 19 9.90e-02 1.69e-01 0.26000 0.019200 -0.260000 8.85e-01 5.01e-02
G2/M DNA damage checkpoint 55 7.35e-03 2.60e-02 0.26000 -0.089400 -0.244000 2.52e-01 1.72e-03
RHOBTB2 GTPase cycle 21 2.04e-01 2.88e-01 0.26000 -0.200000 -0.166000 1.12e-01 1.88e-01
Cell Cycle 561 1.16e-19 1.03e-17 0.26000 -0.133000 -0.223000 6.83e-08 1.76e-19
Carnitine metabolism 11 4.29e-01 5.17e-01 0.26000 -0.211000 -0.151000 2.25e-01 3.87e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 1.79e-01 2.63e-01 0.25900 -0.246000 -0.081200 6.37e-02 5.40e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 1.79e-01 2.63e-01 0.25900 -0.246000 -0.081200 6.37e-02 5.40e-01
Defects in cobalamin (B12) metabolism 12 3.43e-01 4.34e-01 0.25900 -0.085800 -0.244000 6.07e-01 1.43e-01
RHO GTPase cycle 398 5.46e-14 3.45e-12 0.25900 -0.138000 -0.219000 2.28e-06 7.21e-14
Apoptotic execution phase 42 3.74e-02 8.17e-02 0.25800 -0.135000 -0.220000 1.29e-01 1.36e-02
RHO GTPases Activate WASPs and WAVEs 33 8.14e-02 1.46e-01 0.25800 -0.149000 -0.210000 1.38e-01 3.65e-02
Prolonged ERK activation events 14 3.45e-01 4.36e-01 0.25800 -0.149000 -0.210000 3.33e-01 1.73e-01
B-WICH complex positively regulates rRNA expression 29 7.90e-02 1.43e-01 0.25800 -0.088900 -0.242000 4.07e-01 2.43e-02
DNA Damage Recognition in GG-NER 36 2.99e-02 7.04e-02 0.25700 -0.252000 -0.051300 8.87e-03 5.95e-01
G2/M Checkpoints 119 1.75e-05 2.25e-04 0.25700 -0.068900 -0.248000 1.94e-01 3.06e-06
Activated NTRK2 signals through FRS2 and FRS3 11 3.87e-01 4.77e-01 0.25700 -0.092600 -0.240000 5.95e-01 1.69e-01
COPI-dependent Golgi-to-ER retrograde traffic 80 2.46e-03 1.14e-02 0.25700 -0.150000 -0.209000 2.04e-02 1.26e-03
Processing of DNA double-strand break ends 58 9.40e-03 3.16e-02 0.25600 -0.116000 -0.229000 1.27e-01 2.59e-03
Nuclear Envelope Breakdown 47 2.86e-02 6.85e-02 0.25600 -0.144000 -0.212000 8.70e-02 1.20e-02
Regulation of RUNX2 expression and activity 71 3.06e-03 1.31e-02 0.25600 -0.110000 -0.231000 1.08e-01 7.46e-04
Homology Directed Repair 92 1.04e-03 5.94e-03 0.25600 -0.150000 -0.208000 1.27e-02 5.76e-04
Cyclin A:Cdk2-associated events at S phase entry 83 7.46e-04 4.64e-03 0.25600 -0.087500 -0.241000 1.68e-01 1.48e-04
Cyclin E associated events during G1/S transition 81 1.02e-03 5.89e-03 0.25600 -0.094000 -0.238000 1.44e-01 2.09e-04
Signaling by BMP 27 1.32e-01 2.09e-01 0.25600 -0.147000 -0.210000 1.87e-01 5.92e-02
Regulation of IFNG signaling 14 3.14e-01 4.05e-01 0.25600 -0.104000 -0.234000 5.00e-01 1.30e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 1.62e-01 2.44e-01 0.25600 0.099300 -0.236000 5.35e-01 1.41e-01
G2/M Transition 165 6.27e-07 1.25e-05 0.25600 -0.085100 -0.241000 5.92e-02 9.06e-08
Interleukin-15 signaling 13 2.84e-01 3.71e-01 0.25600 -0.049500 -0.251000 7.57e-01 1.18e-01
Protein ubiquitination 59 1.14e-02 3.60e-02 0.25500 -0.138000 -0.215000 6.66e-02 4.31e-03
Mitotic G2-G2/M phases 167 6.01e-07 1.22e-05 0.25500 -0.087200 -0.240000 5.20e-02 8.69e-08
SCF(Skp2)-mediated degradation of p27/p21 58 3.97e-03 1.64e-02 0.25500 -0.052900 -0.250000 4.86e-01 1.00e-03
Regulation of signaling by NODAL 11 4.21e-01 5.10e-01 0.25500 0.122000 0.224000 4.83e-01 1.98e-01
HIV Infection 208 1.86e-08 5.44e-07 0.25500 -0.086600 -0.240000 3.14e-02 2.43e-09
PIWI-interacting RNA (piRNA) biogenesis 28 7.03e-02 1.31e-01 0.25500 0.249000 0.054300 2.25e-02 6.19e-01
PRC2 methylates histones and DNA 13 3.79e-01 4.69e-01 0.25500 -0.145000 -0.209000 3.64e-01 1.91e-01
Signaling by ERBB2 in Cancer 25 1.61e-01 2.43e-01 0.25500 -0.200000 -0.158000 8.39e-02 1.71e-01
Condensation of Prometaphase Chromosomes 11 4.21e-01 5.10e-01 0.25500 -0.119000 -0.225000 4.95e-01 1.96e-01
Peptide ligand-binding receptors 180 1.03e-06 1.84e-05 0.25400 0.125000 0.221000 3.77e-03 3.12e-07
IRE1alpha activates chaperones 49 2.54e-02 6.24e-02 0.25400 -0.138000 -0.213000 9.51e-02 9.75e-03
TBC/RABGAPs 42 4.34e-02 9.19e-02 0.25400 -0.140000 -0.212000 1.17e-01 1.73e-02
Intrinsic Pathway of Fibrin Clot Formation 21 2.20e-01 3.07e-01 0.25400 0.192000 0.166000 1.27e-01 1.88e-01
Spry regulation of FGF signaling 16 1.26e-01 2.03e-01 0.25400 -0.245000 0.066500 9.01e-02 6.45e-01
Signaling by Erythropoietin 25 9.81e-02 1.68e-01 0.25400 -0.057200 -0.247000 6.20e-01 3.25e-02
Fcgamma receptor (FCGR) dependent phagocytosis 81 2.94e-03 1.30e-02 0.25300 -0.158000 -0.198000 1.42e-02 2.04e-03
Potential therapeutics for SARS 83 2.76e-03 1.24e-02 0.25300 -0.183000 -0.175000 4.03e-03 5.73e-03
tRNA modification in the nucleus and cytosol 33 2.28e-02 5.82e-02 0.25300 0.017000 -0.253000 8.65e-01 1.20e-02
Signaling by TGFB family members 114 2.06e-04 1.66e-03 0.25300 -0.135000 -0.214000 1.26e-02 7.99e-05
Frs2-mediated activation 12 4.11e-01 5.00e-01 0.25300 -0.139000 -0.211000 4.04e-01 2.05e-01
RHOQ GTPase cycle 53 1.73e-02 4.82e-02 0.25300 -0.124000 -0.221000 1.19e-01 5.44e-03
Mitochondrial Fatty Acid Beta-Oxidation 33 6.56e-02 1.25e-01 0.25300 -0.094800 -0.234000 3.46e-01 1.98e-02
Phenylalanine and tyrosine metabolism 10 4.92e-01 5.72e-01 0.25200 0.190000 0.166000 2.98e-01 3.63e-01
MET promotes cell motility 29 2.51e-02 6.18e-02 0.25200 0.063300 -0.244000 5.55e-01 2.29e-02
Signaling by FGFR3 39 4.09e-02 8.76e-02 0.25200 -0.234000 -0.095200 1.16e-02 3.04e-01
Regulation of TP53 Activity through Phosphorylation 86 1.96e-03 9.76e-03 0.25200 -0.145000 -0.206000 2.02e-02 9.50e-04
Glycerophospholipid biosynthesis 112 2.85e-05 3.42e-04 0.25100 -0.247000 -0.048100 6.39e-06 3.79e-01
Epigenetic regulation of gene expression 83 3.05e-03 1.31e-02 0.25100 -0.179000 -0.176000 4.70e-03 5.69e-03
Apoptotic cleavage of cellular proteins 34 5.97e-02 1.17e-01 0.25100 -0.087700 -0.235000 3.76e-01 1.76e-02
Response of Mtb to phagocytosis 22 1.86e-01 2.70e-01 0.25100 -0.222000 -0.117000 7.13e-02 3.43e-01
Phase II - Conjugation of compounds 101 9.17e-04 5.40e-03 0.25000 0.182000 0.172000 1.61e-03 2.81e-03
Signaling by FLT3 ITD and TKD mutants 16 3.30e-01 4.20e-01 0.25000 -0.170000 -0.183000 2.39e-01 2.05e-01
ISG15 antiviral mechanism 70 7.79e-03 2.72e-02 0.24900 -0.161000 -0.190000 1.95e-02 5.97e-03
APC-Cdc20 mediated degradation of Nek2A 24 8.12e-02 1.45e-01 0.24900 -0.249000 -0.003230 3.50e-02 9.78e-01
Apoptotic cleavage of cell adhesion proteins 11 3.58e-01 4.49e-01 0.24800 -0.041000 -0.245000 8.14e-01 1.59e-01
FGFR3 mutant receptor activation 11 4.47e-01 5.31e-01 0.24800 -0.214000 -0.126000 2.19e-01 4.71e-01
Signaling by activated point mutants of FGFR3 11 4.47e-01 5.31e-01 0.24800 -0.214000 -0.126000 2.19e-01 4.71e-01
SUMOylation of DNA replication proteins 43 5.29e-02 1.07e-01 0.24800 -0.164000 -0.186000 6.30e-02 3.50e-02
Phospholipase C-mediated cascade; FGFR4 14 3.62e-01 4.52e-01 0.24800 -0.127000 -0.213000 4.10e-01 1.68e-01
Response to metal ions 14 1.39e-01 2.19e-01 0.24800 -0.191000 0.158000 2.17e-01 3.06e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 26 1.68e-01 2.51e-01 0.24800 -0.189000 -0.159000 9.45e-02 1.59e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 12 1.86e-01 2.70e-01 0.24700 -0.190000 0.158000 2.55e-01 3.44e-01
Dual incision in TC-NER 62 6.07e-03 2.26e-02 0.24700 -0.077100 -0.235000 2.94e-01 1.40e-03
NoRC negatively regulates rRNA expression 43 5.04e-02 1.03e-01 0.24700 -0.144000 -0.201000 1.03e-01 2.28e-02
PI3K/AKT Signaling in Cancer 100 1.18e-03 6.46e-03 0.24700 -0.165000 -0.183000 4.31e-03 1.56e-03
Endogenous sterols 26 9.90e-02 1.69e-01 0.24600 -0.241000 -0.050700 3.34e-02 6.54e-01
Negative regulation of NOTCH4 signaling 52 1.23e-02 3.80e-02 0.24600 -0.066400 -0.237000 4.07e-01 3.10e-03
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 12 4.21e-01 5.10e-01 0.24600 0.123000 0.213000 4.61e-01 2.01e-01
Metallothioneins bind metals 11 2.49e-01 3.35e-01 0.24600 -0.083000 0.232000 6.33e-01 1.83e-01
Chylomicron remodeling 10 3.13e-01 4.04e-01 0.24600 -0.044500 0.242000 8.07e-01 1.85e-01
RHO GTPase Effectors 228 4.88e-08 1.33e-06 0.24600 -0.108000 -0.221000 4.78e-03 9.61e-09
Transmission across Chemical Synapses 236 1.54e-07 3.90e-06 0.24600 -0.167000 -0.180000 9.64e-06 1.89e-06
Mitotic Metaphase and Anaphase 212 2.43e-07 5.59e-06 0.24600 -0.119000 -0.215000 2.74e-03 7.02e-08
WNT ligand biogenesis and trafficking 24 1.63e-01 2.45e-01 0.24500 -0.223000 -0.103000 5.86e-02 3.84e-01
Regulation of RAS by GAPs 66 5.83e-03 2.20e-02 0.24500 -0.090800 -0.228000 2.02e-01 1.36e-03
Oncogene Induced Senescence 32 3.70e-02 8.11e-02 0.24500 -0.245000 0.000967 1.63e-02 9.92e-01
Base Excision Repair 45 4.08e-02 8.75e-02 0.24500 -0.125000 -0.211000 1.47e-01 1.43e-02
The NLRP3 inflammasome 16 2.47e-01 3.34e-01 0.24500 -0.239000 -0.053000 9.77e-02 7.13e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 1.81e-01 2.65e-01 0.24500 -0.244000 -0.026200 7.37e-02 8.47e-01
E3 ubiquitin ligases ubiquitinate target proteins 42 5.87e-02 1.16e-01 0.24500 -0.151000 -0.193000 9.11e-02 3.05e-02
Response of EIF2AK1 (HRI) to heme deficiency 14 3.58e-01 4.49e-01 0.24500 -0.111000 -0.218000 4.71e-01 1.58e-01
HCMV Late Events 50 3.52e-02 7.85e-02 0.24500 -0.189000 -0.156000 2.10e-02 5.67e-02
Signaling by FGFR2 70 7.91e-03 2.75e-02 0.24400 -0.133000 -0.205000 5.37e-02 3.06e-03
Class B/2 (Secretin family receptors) 89 1.63e-03 8.33e-03 0.24400 -0.216000 -0.114000 4.34e-04 6.19e-02
TICAM1-dependent activation of IRF3/IRF7 12 4.26e-01 5.15e-01 0.24400 -0.212000 -0.122000 2.04e-01 4.66e-01
mRNA Splicing - Major Pathway 155 3.14e-06 5.07e-05 0.24400 -0.069600 -0.234000 1.35e-01 5.00e-07
LDL clearance 19 2.13e-01 2.98e-01 0.24400 -0.072800 -0.233000 5.83e-01 7.89e-02
Negative regulation of FGFR3 signaling 28 7.02e-02 1.31e-01 0.24400 -0.243000 -0.022500 2.63e-02 8.37e-01
Sphingolipid metabolism 72 8.90e-03 3.03e-02 0.24300 -0.167000 -0.177000 1.41e-02 9.57e-03
Clathrin-mediated endocytosis 133 1.68e-04 1.45e-03 0.24300 -0.164000 -0.180000 1.11e-03 3.49e-04
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 27 1.49e-01 2.30e-01 0.24300 -0.212000 -0.119000 5.67e-02 2.86e-01
Chondroitin sulfate biosynthesis 18 2.24e-01 3.10e-01 0.24300 -0.235000 -0.062100 8.48e-02 6.48e-01
Mitotic Anaphase 211 3.57e-07 7.74e-06 0.24300 -0.115000 -0.213000 3.86e-03 9.34e-08
Cytoprotection by HMOX1 55 2.74e-02 6.62e-02 0.24200 -0.184000 -0.158000 1.85e-02 4.26e-02
RAC1 GTPase cycle 159 3.75e-06 5.92e-05 0.24200 -0.075800 -0.230000 9.91e-02 5.80e-07
COPI-mediated anterograde transport 82 8.13e-04 4.92e-03 0.24200 -0.044500 -0.237000 4.86e-01 2.02e-04
G0 and Early G1 27 1.25e-01 2.02e-01 0.24100 -0.081700 -0.227000 4.62e-01 4.13e-02
RHOF GTPase cycle 37 7.46e-02 1.36e-01 0.24100 -0.115000 -0.212000 2.28e-01 2.56e-02
Mismatch Repair 15 3.69e-01 4.59e-01 0.24100 -0.197000 -0.139000 1.87e-01 3.52e-01
Signaling by NOTCH3 47 3.41e-02 7.75e-02 0.24100 -0.104000 -0.217000 2.18e-01 1.00e-02
Toll Like Receptor 4 (TLR4) Cascade 122 4.05e-04 2.86e-03 0.24100 -0.162000 -0.177000 1.95e-03 7.14e-04
BBSome-mediated cargo-targeting to cilium 22 2.23e-01 3.10e-01 0.24000 -0.123000 -0.206000 3.17e-01 9.39e-02
Resolution of Abasic Sites (AP sites) 37 7.13e-02 1.32e-01 0.24000 -0.104000 -0.216000 2.73e-01 2.28e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 13 1.97e-01 2.80e-01 0.24000 -0.216000 0.104000 1.77e-01 5.18e-01
Reversible hydration of carbon dioxide 11 4.65e-01 5.48e-01 0.24000 -0.211000 -0.113000 2.25e-01 5.17e-01
Rab regulation of trafficking 103 1.46e-03 7.69e-03 0.23900 -0.161000 -0.177000 4.72e-03 1.93e-03
Myogenesis 29 1.52e-01 2.35e-01 0.23900 -0.142000 -0.192000 1.86e-01 7.29e-02
G alpha (z) signalling events 47 3.59e-02 7.94e-02 0.23900 -0.103000 -0.215000 2.20e-01 1.06e-02
Constitutive Signaling by Overexpressed ERBB2 10 5.24e-01 6.00e-01 0.23900 -0.190000 -0.144000 2.98e-01 4.29e-01
Neddylation 224 2.06e-07 4.96e-06 0.23900 -0.110000 -0.212000 4.51e-03 4.76e-08
MAPK family signaling cascades 298 3.19e-09 1.07e-07 0.23900 -0.127000 -0.202000 1.68e-04 2.00e-09
mRNA Splicing - Minor Pathway 48 2.50e-02 6.17e-02 0.23800 -0.074000 -0.227000 3.75e-01 6.62e-03
Miscellaneous transport and binding events 20 1.80e-01 2.63e-01 0.23800 -0.037900 -0.235000 7.69e-01 6.93e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 3.04e-03 1.31e-02 0.23700 -0.184000 -0.150000 2.32e-03 1.28e-02
Toll Like Receptor 2 (TLR2) Cascade 92 3.04e-03 1.31e-02 0.23700 -0.184000 -0.150000 2.32e-03 1.28e-02
Toll Like Receptor TLR1:TLR2 Cascade 92 3.04e-03 1.31e-02 0.23700 -0.184000 -0.150000 2.32e-03 1.28e-02
Toll Like Receptor TLR6:TLR2 Cascade 92 3.04e-03 1.31e-02 0.23700 -0.184000 -0.150000 2.32e-03 1.28e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 4.42e-01 5.30e-01 0.23700 -0.177000 -0.158000 2.69e-01 3.24e-01
FCERI mediated Ca+2 mobilization 27 1.66e-01 2.48e-01 0.23700 -0.121000 -0.204000 2.77e-01 6.62e-02
Glycogen metabolism 23 1.82e-01 2.65e-01 0.23700 -0.222000 -0.082100 6.51e-02 4.96e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 29 1.62e-01 2.44e-01 0.23700 -0.148000 -0.184000 1.67e-01 8.59e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 29 1.62e-01 2.44e-01 0.23700 -0.148000 -0.184000 1.67e-01 8.59e-02
Hedgehog ligand biogenesis 63 8.87e-03 3.03e-02 0.23600 -0.075800 -0.224000 2.98e-01 2.11e-03
Resolution of D-Loop Structures 26 1.93e-01 2.76e-01 0.23600 -0.189000 -0.141000 9.47e-02 2.13e-01
RNA Polymerase I Promoter Escape 28 1.55e-01 2.37e-01 0.23600 -0.114000 -0.206000 2.97e-01 5.89e-02
Asymmetric localization of PCP proteins 62 1.13e-02 3.58e-02 0.23600 -0.084900 -0.220000 2.48e-01 2.78e-03
Interleukin-20 family signaling 22 1.90e-01 2.72e-01 0.23500 0.224000 0.070900 6.86e-02 5.65e-01
mRNA Splicing 165 6.99e-06 1.04e-04 0.23500 -0.083800 -0.220000 6.33e-02 1.12e-06
Formation of Fibrin Clot (Clotting Cascade) 37 1.04e-01 1.76e-01 0.23400 0.152000 0.178000 1.08e-01 6.14e-02
Signaling by Nuclear Receptors 229 8.16e-07 1.55e-05 0.23400 -0.143000 -0.185000 2.01e-04 1.35e-06
Transport of Mature mRNA derived from an Intron-Containing Transcript 54 3.42e-02 7.75e-02 0.23400 -0.134000 -0.191000 8.77e-02 1.50e-02
Deubiquitination 222 2.27e-07 5.29e-06 0.23300 -0.091500 -0.215000 1.88e-02 3.51e-08
Global Genome Nucleotide Excision Repair (GG-NER) 81 6.08e-03 2.26e-02 0.23300 -0.196000 -0.127000 2.32e-03 4.89e-02
Processing of Capped Intron-Containing Pre-mRNA 209 9.12e-07 1.65e-05 0.23300 -0.102000 -0.209000 1.09e-02 1.81e-07
p53-Dependent G1 DNA Damage Response 64 1.21e-02 3.74e-02 0.23300 -0.091800 -0.214000 2.04e-01 3.06e-03
p53-Dependent G1/S DNA damage checkpoint 64 1.21e-02 3.74e-02 0.23300 -0.091800 -0.214000 2.04e-01 3.06e-03
SUMOylation of RNA binding proteins 44 6.73e-02 1.27e-01 0.23300 -0.139000 -0.186000 1.10e-01 3.25e-02
Organic cation/anion/zwitterion transport 15 1.80e-01 2.63e-01 0.23200 -0.215000 0.086600 1.49e-01 5.62e-01
Positive epigenetic regulation of rRNA expression 43 7.21e-02 1.32e-01 0.23200 -0.188000 -0.136000 3.33e-02 1.22e-01
MAPK1/MAPK3 signaling 262 8.22e-08 2.19e-06 0.23200 -0.122000 -0.197000 7.06e-04 3.93e-08
RAB GEFs exchange GTP for GDP on RABs 72 1.39e-02 4.14e-02 0.23100 -0.167000 -0.161000 1.44e-02 1.85e-02
Interleukin-35 Signalling 12 2.75e-01 3.63e-01 0.23100 0.060900 -0.223000 7.15e-01 1.81e-01
Extension of Telomeres 45 5.65e-02 1.12e-01 0.23100 -0.112000 -0.202000 1.92e-01 1.93e-02
Oxidative Stress Induced Senescence 62 2.56e-02 6.25e-02 0.23100 -0.156000 -0.170000 3.31e-02 2.08e-02
Deadenylation-dependent mRNA decay 54 3.56e-02 7.91e-02 0.23100 -0.126000 -0.193000 1.09e-01 1.40e-02
RAF/MAP kinase cascade 256 1.41e-07 3.62e-06 0.23100 -0.121000 -0.196000 8.39e-04 6.67e-08
Glycosaminoglycan metabolism 111 1.18e-03 6.46e-03 0.23000 -0.190000 -0.131000 5.62e-04 1.71e-02
CTLA4 inhibitory signaling 21 1.96e-01 2.79e-01 0.23000 -0.047900 -0.225000 7.04e-01 7.41e-02
Membrane Trafficking 562 3.26e-15 2.25e-13 0.23000 -0.130000 -0.190000 1.57e-07 1.36e-14
Nuclear import of Rev protein 31 1.53e-01 2.35e-01 0.23000 -0.132000 -0.188000 2.02e-01 6.99e-02
Regulation of insulin secretion 76 1.16e-02 3.64e-02 0.23000 -0.173000 -0.151000 9.17e-03 2.28e-02
Integration of energy metabolism 105 2.06e-03 1.00e-02 0.22900 -0.180000 -0.142000 1.47e-03 1.18e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 14 3.24e-01 4.14e-01 0.22900 0.033700 0.227000 8.27e-01 1.42e-01
Diseases of hemostasis 14 3.24e-01 4.14e-01 0.22900 0.033700 0.227000 8.27e-01 1.42e-01
S Phase 148 9.80e-05 9.24e-04 0.22900 -0.113000 -0.199000 1.80e-02 2.82e-05
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 50 1.43e-02 4.21e-02 0.22900 -0.015700 -0.228000 8.48e-01 5.27e-03
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 75 9.41e-03 3.16e-02 0.22900 -0.113000 -0.199000 8.99e-02 2.94e-03
G1/S DNA Damage Checkpoints 66 1.12e-02 3.57e-02 0.22800 -0.082200 -0.213000 2.48e-01 2.74e-03
Apoptosis 163 7.83e-05 7.98e-04 0.22800 -0.147000 -0.175000 1.22e-03 1.16e-04
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 2.69e-03 1.21e-02 0.22800 -0.027900 -0.226000 6.80e-01 8.26e-04
Signaling by ERBB2 TMD/JMD mutants 21 2.89e-01 3.76e-01 0.22800 -0.184000 -0.135000 1.45e-01 2.84e-01
Hedgehog ‘off’ state 97 1.84e-03 9.23e-03 0.22800 -0.094100 -0.207000 1.09e-01 4.20e-04
TNFs bind their physiological receptors 24 2.06e-01 2.90e-01 0.22700 0.089900 0.209000 4.46e-01 7.64e-02
PCP/CE pathway 90 1.29e-03 6.96e-03 0.22700 -0.053400 -0.221000 3.81e-01 2.91e-04
Trafficking of GluR2-containing AMPA receptors 15 1.71e-01 2.54e-01 0.22700 0.135000 -0.183000 3.66e-01 2.20e-01
Signaling by NOTCH 176 1.15e-05 1.56e-04 0.22700 -0.091400 -0.207000 3.66e-02 2.07e-06
Orc1 removal from chromatin 63 9.75e-03 3.23e-02 0.22600 -0.053000 -0.220000 4.67e-01 2.51e-03
Signaling by Hedgehog 133 3.85e-04 2.74e-03 0.22600 -0.123000 -0.190000 1.46e-02 1.56e-04
Regulation of actin dynamics for phagocytic cup formation 58 3.69e-02 8.10e-02 0.22600 -0.171000 -0.148000 2.46e-02 5.09e-02
GLI3 is processed to GLI3R by the proteasome 58 1.45e-02 4.21e-02 0.22600 -0.053400 -0.219000 4.82e-01 3.85e-03
Regulation of PTEN stability and activity 66 1.14e-02 3.59e-02 0.22600 -0.074700 -0.213000 2.94e-01 2.77e-03
Host Interactions of HIV factors 121 2.05e-04 1.66e-03 0.22500 -0.062900 -0.217000 2.32e-01 3.90e-05
Infection with Mycobacterium tuberculosis 26 1.89e-01 2.71e-01 0.22500 -0.206000 -0.091500 6.94e-02 4.19e-01
Transcriptional Regulation by E2F6 32 1.65e-01 2.47e-01 0.22500 -0.165000 -0.153000 1.05e-01 1.35e-01
PCNA-Dependent Long Patch Base Excision Repair 21 2.75e-01 3.63e-01 0.22500 -0.105000 -0.199000 4.04e-01 1.14e-01
DNA Replication Pre-Initiation 88 3.00e-03 1.31e-02 0.22500 -0.080600 -0.210000 1.92e-01 6.57e-04
Presynaptic function of Kainate receptors 21 2.62e-01 3.50e-01 0.22500 -0.091600 -0.205000 4.68e-01 1.03e-01
Intracellular signaling by second messengers 301 4.83e-08 1.33e-06 0.22500 -0.141000 -0.175000 2.53e-05 1.83e-07
CD28 dependent PI3K/Akt signaling 22 2.04e-01 2.88e-01 0.22500 -0.053500 -0.218000 6.64e-01 7.65e-02
Phospholipid metabolism 189 4.74e-06 7.34e-05 0.22500 -0.209000 -0.083100 7.60e-07 4.88e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 4.57e-01 5.40e-01 0.22500 -0.155000 -0.162000 3.15e-01 2.93e-01
Signaling by FGFR 83 9.15e-03 3.09e-02 0.22500 -0.140000 -0.176000 2.78e-02 5.65e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins 15 2.71e-01 3.59e-01 0.22400 0.224000 -0.003880 1.32e-01 9.79e-01
Nuclear Pore Complex (NPC) Disassembly 33 1.57e-01 2.40e-01 0.22400 -0.144000 -0.171000 1.52e-01 8.83e-02
ADP signalling through P2Y purinoceptor 12 20 2.77e-01 3.64e-01 0.22400 -0.086000 -0.207000 5.06e-01 1.10e-01
Negative regulation of FGFR2 signaling 32 8.96e-02 1.57e-01 0.22300 -0.220000 -0.037500 3.10e-02 7.14e-01
Nucleotide Excision Repair 106 2.73e-03 1.23e-02 0.22300 -0.142000 -0.173000 1.16e-02 2.15e-03
Synthesis of Leukotrienes (LT) and Eoxins (EX) 21 2.75e-01 3.63e-01 0.22300 0.098700 0.200000 4.34e-01 1.12e-01
Heme signaling 44 5.65e-02 1.12e-01 0.22300 -0.078400 -0.209000 3.68e-01 1.65e-02
MET activates PTK2 signaling 18 2.95e-01 3.84e-01 0.22300 -0.067500 -0.213000 6.20e-01 1.19e-01
Glycolysis 66 2.45e-02 6.07e-02 0.22300 -0.179000 -0.133000 1.21e-02 6.14e-02
Purine salvage 12 5.12e-01 5.91e-01 0.22300 -0.140000 -0.173000 4.01e-01 2.99e-01
Stimuli-sensing channels 86 5.64e-03 2.14e-02 0.22300 -0.198000 -0.103000 1.54e-03 9.99e-02
Interleukin-1 signaling 95 2.99e-03 1.31e-02 0.22300 -0.096900 -0.200000 1.03e-01 7.36e-04
Class I MHC mediated antigen processing & presentation 352 2.04e-09 7.36e-08 0.22300 -0.119000 -0.188000 1.21e-04 1.43e-09
MAPK6/MAPK4 signaling 84 4.06e-03 1.67e-02 0.22200 -0.074900 -0.209000 2.35e-01 9.06e-04
Transcriptional regulation by RUNX1 169 8.68e-05 8.45e-04 0.22200 -0.135000 -0.176000 2.39e-03 7.91e-05
PECAM1 interactions 12 3.90e-01 4.80e-01 0.22200 -0.022000 -0.221000 8.95e-01 1.85e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 3.70e-01 4.60e-01 0.22200 -0.191000 -0.112000 1.72e-01 4.23e-01
Surfactant metabolism 28 4.89e-02 1.01e-01 0.22200 -0.102000 0.197000 3.51e-01 7.15e-02
Golgi-to-ER retrograde transport 114 1.03e-03 5.94e-03 0.22100 -0.097100 -0.199000 7.33e-02 2.44e-04
Prefoldin mediated transfer of substrate to CCT/TriC 25 8.11e-02 1.45e-01 0.22100 0.069700 -0.209000 5.46e-01 7.02e-02
Degradation of AXIN 53 3.20e-02 7.38e-02 0.22100 -0.072200 -0.208000 3.63e-01 8.69e-03
Xenobiotics 23 2.09e-01 2.94e-01 0.22000 0.058000 0.212000 6.30e-01 7.79e-02
Signaling by FGFR1 49 5.92e-02 1.16e-01 0.22000 -0.191000 -0.108000 2.04e-02 1.91e-01
FRS-mediated FGFR1 signaling 23 2.74e-01 3.62e-01 0.22000 -0.186000 -0.117000 1.23e-01 3.31e-01
Signaling by FGFR4 40 1.15e-01 1.90e-01 0.21900 -0.172000 -0.137000 6.00e-02 1.35e-01
Antiviral mechanism by IFN-stimulated genes 77 1.54e-02 4.40e-02 0.21900 -0.132000 -0.175000 4.53e-02 8.00e-03
Asparagine N-linked glycosylation 273 2.08e-07 4.96e-06 0.21900 -0.110000 -0.190000 1.81e-03 7.12e-08
Gap-filling DNA repair synthesis and ligation in TC-NER 61 1.98e-02 5.31e-02 0.21900 -0.069900 -0.207000 3.45e-01 5.11e-03
NS1 Mediated Effects on Host Pathways 38 1.33e-01 2.11e-01 0.21900 -0.153000 -0.157000 1.04e-01 9.47e-02
FRS-mediated FGFR3 signaling 19 3.62e-01 4.52e-01 0.21900 -0.140000 -0.168000 2.90e-01 2.06e-01
ER to Golgi Anterograde Transport 130 4.32e-04 3.02e-03 0.21800 -0.088600 -0.199000 8.13e-02 9.00e-05
Citric acid cycle (TCA cycle) 21 2.79e-01 3.65e-01 0.21700 -0.082600 -0.201000 5.12e-01 1.11e-01
Prolactin receptor signaling 15 3.45e-01 4.36e-01 0.21700 0.037800 0.214000 8.00e-01 1.51e-01
Activated point mutants of FGFR2 15 4.47e-01 5.31e-01 0.21700 -0.174000 -0.130000 2.43e-01 3.83e-01
SUMOylation of SUMOylation proteins 32 1.76e-01 2.60e-01 0.21700 -0.122000 -0.180000 2.33e-01 7.83e-02
Signaling by Retinoic Acid 40 9.94e-02 1.69e-01 0.21700 -0.194000 -0.096900 3.39e-02 2.89e-01
Transcription of E2F targets under negative control by DREAM complex 19 3.71e-01 4.61e-01 0.21700 -0.150000 -0.156000 2.56e-01 2.39e-01
Synthesis of substrates in N-glycan biosythesis 59 1.40e-02 4.14e-02 0.21600 -0.029100 -0.214000 6.99e-01 4.38e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 5.93e-01 6.58e-01 0.21600 -0.141000 -0.164000 4.40e-01 3.69e-01
Factors involved in megakaryocyte development and platelet production 120 8.48e-04 5.07e-03 0.21600 -0.087400 -0.198000 9.82e-02 1.82e-04
Metabolism of steroid hormones 33 1.37e-01 2.16e-01 0.21600 0.081500 0.200000 4.18e-01 4.65e-02
Signaling by KIT in disease 20 2.26e-01 3.13e-01 0.21500 -0.019100 -0.215000 8.82e-01 9.66e-02
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 2.26e-01 3.13e-01 0.21500 -0.019100 -0.215000 8.82e-01 9.66e-02
PKMTs methylate histone lysines 32 8.17e-02 1.46e-01 0.21500 -0.003390 -0.215000 9.74e-01 3.50e-02
Tryptophan catabolism 11 4.38e-01 5.26e-01 0.21500 0.015900 0.215000 9.27e-01 2.18e-01
DNA strand elongation 30 9.07e-02 1.59e-01 0.21500 0.003830 -0.215000 9.71e-01 4.14e-02
Nuclear events mediated by NFE2L2 76 7.33e-03 2.60e-02 0.21500 -0.056600 -0.207000 3.93e-01 1.78e-03
Dual Incision in GG-NER 39 1.32e-01 2.10e-01 0.21500 -0.134000 -0.168000 1.48e-01 6.93e-02
Ubiquitin-dependent degradation of Cyclin D 50 3.59e-02 7.94e-02 0.21400 -0.046700 -0.209000 5.68e-01 1.06e-02
Striated Muscle Contraction 33 3.19e-02 7.38e-02 0.21400 -0.173000 0.126000 8.55e-02 2.10e-01
FGFR2c ligand binding and activation 12 4.25e-01 5.14e-01 0.21400 -0.027600 -0.212000 8.69e-01 2.03e-01
Assembly of the pre-replicative complex 74 1.38e-02 4.11e-02 0.21400 -0.086000 -0.196000 2.01e-01 3.58e-03
Hyaluronan uptake and degradation 11 4.75e-01 5.57e-01 0.21400 -0.210000 -0.041500 2.28e-01 8.12e-01
Muscle contraction 186 8.47e-05 8.30e-04 0.21400 -0.155000 -0.147000 2.68e-04 5.27e-04
Signalling to RAS 20 3.25e-01 4.15e-01 0.21400 -0.095500 -0.191000 4.60e-01 1.39e-01
Transcriptional Regulation by VENTX 36 1.24e-01 2.02e-01 0.21300 -0.196000 -0.084900 4.20e-02 3.78e-01
Cytosolic sensors of pathogen-associated DNA 60 2.57e-02 6.26e-02 0.21300 -0.068900 -0.202000 3.56e-01 6.80e-03
Resolution of D-loop Structures through Holliday Junction Intermediates 25 2.82e-01 3.68e-01 0.21300 -0.158000 -0.143000 1.71e-01 2.15e-01
Signaling by ROBO receptors 201 2.54e-06 4.15e-05 0.21300 -0.053100 -0.207000 1.95e-01 4.40e-07
Glutamate and glutamine metabolism 12 5.30e-01 6.04e-01 0.21300 -0.179000 -0.116000 2.83e-01 4.86e-01
Metabolism of polyamines 54 1.99e-02 5.32e-02 0.21300 -0.018800 -0.212000 8.11e-01 7.02e-03
Formation of TC-NER Pre-Incision Complex 50 6.56e-02 1.25e-01 0.21300 -0.102000 -0.187000 2.13e-01 2.23e-02
Downstream signaling of activated FGFR1 31 2.07e-01 2.91e-01 0.21300 -0.132000 -0.167000 2.05e-01 1.08e-01
Phosphorylation of the APC/C 18 2.79e-01 3.65e-01 0.21200 -0.211000 -0.023200 1.22e-01 8.64e-01
Negative regulation of the PI3K/AKT network 109 4.44e-03 1.78e-02 0.21200 -0.147000 -0.153000 8.23e-03 5.72e-03
TRAF6 mediated IRF7 activation 20 1.26e-01 2.03e-01 0.21200 0.142000 -0.157000 2.70e-01 2.24e-01
Regulation of TP53 Activity through Acetylation 28 1.47e-01 2.29e-01 0.21200 -0.209000 -0.032900 5.52e-02 7.63e-01
PI Metabolism 78 2.10e-02 5.48e-02 0.21100 -0.156000 -0.143000 1.74e-02 2.92e-02
Signaling by BRAF and RAF1 fusions 59 2.22e-02 5.72e-02 0.21100 -0.047300 -0.206000 5.30e-01 6.21e-03
RIPK1-mediated regulated necrosis 27 8.74e-02 1.54e-01 0.21100 -0.203000 0.058000 6.78e-02 6.02e-01
Regulation of necroptotic cell death 27 8.74e-02 1.54e-01 0.21100 -0.203000 0.058000 6.78e-02 6.02e-01
SUMOylation of transcription cofactors 43 1.19e-01 1.95e-01 0.21100 -0.142000 -0.156000 1.07e-01 7.67e-02
PI3K events in ERBB2 signaling 16 4.53e-01 5.37e-01 0.21100 -0.141000 -0.157000 3.28e-01 2.78e-01
Blood group systems biosynthesis 22 3.28e-01 4.19e-01 0.21100 0.124000 0.171000 3.15e-01 1.66e-01
Hh mutants abrogate ligand secretion 57 2.15e-02 5.58e-02 0.21100 -0.033200 -0.208000 6.65e-01 6.61e-03
Activation of G protein gated Potassium channels 29 2.40e-01 3.28e-01 0.21100 -0.143000 -0.154000 1.82e-01 1.50e-01
G protein gated Potassium channels 29 2.40e-01 3.28e-01 0.21100 -0.143000 -0.154000 1.82e-01 1.50e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 29 2.40e-01 3.28e-01 0.21100 -0.143000 -0.154000 1.82e-01 1.50e-01
Signaling by CSF3 (G-CSF) 28 2.46e-01 3.33e-01 0.21000 -0.127000 -0.168000 2.45e-01 1.24e-01
Diseases of glycosylation 129 1.74e-03 8.86e-03 0.21000 -0.135000 -0.161000 7.94e-03 1.59e-03
Nuclear Envelope (NE) Reassembly 68 3.53e-02 7.88e-02 0.21000 -0.140000 -0.157000 4.61e-02 2.51e-02
Glycosphingolipid metabolism 39 9.97e-02 1.70e-01 0.21000 -0.068000 -0.199000 4.63e-01 3.18e-02
Metabolic disorders of biological oxidation enzymes 32 6.66e-02 1.26e-01 0.21000 -0.206000 0.038900 4.36e-02 7.04e-01
Protein folding 94 1.60e-03 8.19e-03 0.21000 -0.025400 -0.208000 6.71e-01 4.89e-04
Signaling by FLT3 fusion proteins 19 3.39e-01 4.30e-01 0.20900 -0.077100 -0.195000 5.60e-01 1.42e-01
HDR through MMEJ (alt-NHEJ) 11 4.11e-01 5.01e-01 0.20900 0.025300 -0.207000 8.85e-01 2.34e-01
Disease 1577 1.07e-31 2.72e-29 0.20800 -0.126000 -0.165000 9.66e-17 7.63e-28
Class A/1 (Rhodopsin-like receptors) 294 3.16e-07 7.06e-06 0.20800 0.102000 0.181000 2.74e-03 9.43e-08
Hedgehog ‘on’ state 83 1.16e-02 3.64e-02 0.20800 -0.087500 -0.188000 1.68e-01 3.04e-03
FRS-mediated FGFR2 signaling 23 3.29e-01 4.20e-01 0.20700 -0.127000 -0.163000 2.92e-01 1.75e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 32 1.33e-01 2.11e-01 0.20600 -0.040500 -0.202000 6.92e-01 4.74e-02
SHC-mediated cascade:FGFR3 17 4.33e-01 5.22e-01 0.20600 -0.115000 -0.172000 4.14e-01 2.20e-01
Gene expression (Transcription) 1329 9.65e-28 1.83e-25 0.20600 -0.109000 -0.176000 3.45e-11 8.06e-27
Transport to the Golgi and subsequent modification 161 3.07e-04 2.29e-03 0.20600 -0.104000 -0.178000 2.31e-02 9.42e-05
Regulation of RUNX3 expression and activity 53 4.21e-02 9.00e-02 0.20600 -0.053400 -0.199000 5.01e-01 1.22e-02
FCERI mediated MAPK activation 29 1.56e-01 2.39e-01 0.20600 -0.034400 -0.203000 7.48e-01 5.85e-02
The canonical retinoid cycle in rods (twilight vision) 23 3.19e-01 4.10e-01 0.20500 0.176000 0.106000 1.45e-01 3.77e-01
Regulation of ornithine decarboxylase (ODC) 49 2.91e-02 6.95e-02 0.20500 0.001590 -0.205000 9.85e-01 1.30e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 177 4.88e-05 5.22e-04 0.20500 -0.065800 -0.194000 1.31e-01 8.36e-06
SHC-mediated cascade:FGFR1 21 3.63e-01 4.52e-01 0.20500 -0.169000 -0.116000 1.80e-01 3.59e-01
Growth hormone receptor signaling 24 3.06e-01 3.97e-01 0.20500 -0.175000 -0.106000 1.38e-01 3.67e-01
Organic cation transport 10 6.20e-01 6.80e-01 0.20500 -0.119000 -0.167000 5.15e-01 3.62e-01
Signal Transduction 2309 1.96e-43 7.45e-41 0.20400 -0.117000 -0.167000 3.52e-20 2.34e-39
Erythropoietin activates RAS 14 4.55e-01 5.38e-01 0.20400 -0.064600 -0.194000 6.76e-01 2.09e-01
SUMOylation of ubiquitinylation proteins 36 1.87e-01 2.71e-01 0.20400 -0.132000 -0.156000 1.70e-01 1.06e-01
Cell-Cell communication 111 5.28e-03 2.02e-02 0.20400 -0.120000 -0.165000 2.90e-02 2.66e-03
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 38 7.76e-02 1.41e-01 0.20400 -0.015200 -0.203000 8.72e-01 3.01e-02
Regulation of Apoptosis 51 2.51e-02 6.18e-02 0.20400 0.005640 -0.204000 9.44e-01 1.18e-02
Vesicle-mediated transport 598 9.76e-13 5.49e-11 0.20400 -0.117000 -0.167000 9.92e-07 3.44e-12
DNA Replication 116 2.06e-03 1.00e-02 0.20400 -0.077000 -0.189000 1.52e-01 4.48e-04
RNA Polymerase II Transcription 1197 2.08e-24 3.15e-22 0.20400 -0.110000 -0.171000 1.39e-10 2.24e-23
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 61 2.42e-02 6.01e-02 0.20400 -0.040900 -0.200000 5.81e-01 7.02e-03
Thyroxine biosynthesis 10 6.30e-01 6.87e-01 0.20400 0.150000 0.138000 4.12e-01 4.50e-01
SARS-CoV Infections 323 4.35e-07 8.92e-06 0.20400 -0.140000 -0.148000 1.49e-05 5.18e-06
E2F mediated regulation of DNA replication 14 4.56e-01 5.40e-01 0.20300 -0.063500 -0.193000 6.81e-01 2.11e-01
EPHA-mediated growth cone collapse 15 5.00e-01 5.80e-01 0.20300 -0.154000 -0.132000 3.01e-01 3.75e-01
Eicosanoid ligand-binding receptors 13 4.46e-01 5.31e-01 0.20300 -0.200000 -0.035500 2.12e-01 8.24e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 5.09e-01 5.87e-01 0.20300 -0.172000 -0.108000 2.65e-01 4.84e-01
Nuclear signaling by ERBB4 31 2.20e-01 3.06e-01 0.20300 -0.175000 -0.103000 9.14e-02 3.22e-01
MET activates RAS signaling 11 3.58e-01 4.49e-01 0.20300 0.168000 -0.114000 3.36e-01 5.11e-01
SUMOylation of DNA damage response and repair proteins 70 3.71e-02 8.11e-02 0.20300 -0.115000 -0.167000 9.56e-02 1.58e-02
Selective autophagy 58 7.16e-02 1.32e-01 0.20300 -0.142000 -0.145000 6.21e-02 5.65e-02
RHOH GTPase cycle 35 2.00e-01 2.84e-01 0.20200 -0.157000 -0.127000 1.07e-01 1.93e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 6.04e-01 6.68e-01 0.20200 -0.182000 -0.087800 3.20e-01 6.31e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 13 5.53e-01 6.26e-01 0.20200 -0.131000 -0.154000 4.15e-01 3.37e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 3.49e-02 7.83e-02 0.20100 -0.008140 -0.201000 9.21e-01 1.39e-02
p53-Independent DNA Damage Response 50 3.49e-02 7.83e-02 0.20100 -0.008140 -0.201000 9.21e-01 1.39e-02
p53-Independent G1/S DNA damage checkpoint 50 3.49e-02 7.83e-02 0.20100 -0.008140 -0.201000 9.21e-01 1.39e-02
Deadenylation of mRNA 24 2.61e-01 3.50e-01 0.20100 -0.055700 -0.193000 6.37e-01 1.02e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 102 1.07e-02 3.44e-02 0.20100 -0.139000 -0.145000 1.56e-02 1.15e-02
FRS-mediated FGFR4 signaling 21 3.21e-01 4.13e-01 0.20100 -0.064200 -0.190000 6.11e-01 1.32e-01
PIP3 activates AKT signaling 263 9.24e-06 1.32e-04 0.20000 -0.136000 -0.147000 1.45e-04 4.13e-05
Other interleukin signaling 22 2.85e-01 3.72e-01 0.20000 -0.194000 -0.048700 1.15e-01 6.92e-01
Generic Transcription Pathway 1094 2.20e-21 2.38e-19 0.19900 -0.112000 -0.165000 4.77e-10 3.26e-20
Interleukin receptor SHC signaling 23 1.25e-01 2.03e-01 0.19900 0.115000 -0.163000 3.41e-01 1.76e-01
Transport of vitamins, nucleosides, and related molecules 38 3.20e-02 7.38e-02 0.19900 -0.159000 0.120000 8.92e-02 2.02e-01
FCERI mediated NF-kB activation 72 1.61e-02 4.55e-02 0.19900 -0.044200 -0.194000 5.17e-01 4.37e-03
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 69 3.50e-02 7.85e-02 0.19900 -0.089600 -0.178000 1.98e-01 1.06e-02
Constitutive Signaling by EGFRvIII 15 4.74e-01 5.57e-01 0.19900 -0.082000 -0.181000 5.82e-01 2.25e-01
Signaling by EGFRvIII in Cancer 15 4.74e-01 5.57e-01 0.19900 -0.082000 -0.181000 5.82e-01 2.25e-01
Regulation of APC/C activators between G1/S and early anaphase 77 2.55e-02 6.25e-02 0.19900 -0.094400 -0.175000 1.52e-01 7.93e-03
Defective CFTR causes cystic fibrosis 59 2.81e-02 6.72e-02 0.19900 -0.028900 -0.197000 7.01e-01 8.99e-03
SHC-mediated cascade:FGFR4 19 3.22e-01 4.13e-01 0.19900 -0.033100 -0.196000 8.03e-01 1.39e-01
Glycogen storage diseases 13 3.44e-01 4.36e-01 0.19900 -0.187000 0.065400 2.42e-01 6.83e-01
RNA Polymerase I Transcription Termination 27 2.41e-01 3.29e-01 0.19900 -0.065000 -0.188000 5.59e-01 9.16e-02
Unfolded Protein Response (UPR) 86 1.35e-02 4.05e-02 0.19800 -0.078200 -0.182000 2.10e-01 3.46e-03
Post-translational protein modification 1237 6.10e-24 8.42e-22 0.19800 -0.107000 -0.167000 3.04e-10 4.88e-23
Signal transduction by L1 20 4.14e-01 5.03e-01 0.19800 -0.126000 -0.153000 3.30e-01 2.35e-01
Translation 262 2.09e-07 4.96e-06 0.19800 -0.033300 -0.196000 3.54e-01 5.13e-08
FLT3 Signaling 38 1.89e-01 2.71e-01 0.19800 -0.150000 -0.129000 1.09e-01 1.69e-01
RAC2 GTPase cycle 74 2.08e-02 5.48e-02 0.19800 -0.064900 -0.187000 3.35e-01 5.39e-03
mRNA decay by 3’ to 5’ exoribonuclease 15 5.18e-01 5.97e-01 0.19800 -0.150000 -0.129000 3.14e-01 3.86e-01
Vpu mediated degradation of CD4 50 5.03e-02 1.03e-01 0.19700 -0.028100 -0.195000 7.31e-01 1.70e-02
Peptide hormone biosynthesis 11 6.20e-01 6.80e-01 0.19700 0.151000 0.126000 3.85e-01 4.68e-01
Negative regulation of FLT3 15 4.04e-01 4.94e-01 0.19700 -0.195000 -0.025400 1.90e-01 8.65e-01
Degradation of GLI2 by the proteasome 58 3.91e-02 8.46e-02 0.19700 -0.043600 -0.192000 5.66e-01 1.16e-02
SHC-mediated cascade:FGFR2 21 3.88e-01 4.78e-01 0.19600 -0.105000 -0.166000 4.05e-01 1.88e-01
Role of phospholipids in phagocytosis 23 1.80e-01 2.63e-01 0.19600 0.037500 -0.193000 7.55e-01 1.09e-01
Molecules associated with elastic fibres 30 1.99e-01 2.81e-01 0.19600 -0.052700 -0.189000 6.17e-01 7.30e-02
Hh mutants are degraded by ERAD 54 3.81e-02 8.28e-02 0.19600 -0.022200 -0.195000 7.78e-01 1.32e-02
Acetylcholine regulates insulin secretion 10 6.43e-01 6.99e-01 0.19600 0.113000 0.161000 5.37e-01 3.79e-01
RNA Polymerase I Promoter Clearance 46 1.24e-01 2.02e-01 0.19500 -0.169000 -0.098700 4.77e-02 2.47e-01
Formation of Incision Complex in GG-NER 40 1.84e-01 2.67e-01 0.19500 -0.141000 -0.135000 1.22e-01 1.40e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 29 2.70e-01 3.59e-01 0.19500 -0.099300 -0.168000 3.55e-01 1.17e-01
Trafficking of AMPA receptors 29 2.70e-01 3.59e-01 0.19500 -0.099300 -0.168000 3.55e-01 1.17e-01
Chaperonin-mediated protein folding 88 6.54e-03 2.36e-02 0.19500 -0.033100 -0.192000 5.92e-01 1.84e-03
RNA Polymerase I Transcription 47 1.30e-01 2.07e-01 0.19500 -0.159000 -0.113000 5.92e-02 1.81e-01
FCGR3A-mediated IL10 synthesis 37 2.10e-01 2.94e-01 0.19500 -0.135000 -0.141000 1.57e-01 1.38e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 40 1.77e-01 2.61e-01 0.19500 -0.114000 -0.158000 2.14e-01 8.31e-02
UCH proteinases 81 2.23e-02 5.72e-02 0.19500 -0.084400 -0.176000 1.89e-01 6.30e-03
G beta:gamma signalling through PLC beta 20 3.60e-01 4.51e-01 0.19500 -0.062100 -0.185000 6.31e-01 1.53e-01
Inactivation of CSF3 (G-CSF) signaling 23 3.71e-01 4.61e-01 0.19500 -0.157000 -0.116000 1.94e-01 3.36e-01
Transport of bile salts and organic acids, metal ions and amine compounds 84 1.99e-03 9.88e-03 0.19500 -0.190000 0.041400 2.57e-03 5.12e-01
Insulin receptor signalling cascade 52 1.08e-01 1.81e-01 0.19500 -0.119000 -0.154000 1.39e-01 5.41e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 70 3.65e-02 8.04e-02 0.19500 -0.081500 -0.177000 2.38e-01 1.06e-02
Degradation of GLI1 by the proteasome 58 3.41e-02 7.75e-02 0.19400 -0.027000 -0.193000 7.22e-01 1.12e-02
Switching of origins to a post-replicative state 82 2.18e-02 5.64e-02 0.19400 -0.083800 -0.175000 1.89e-01 6.14e-03
Fc epsilon receptor (FCERI) signaling 124 1.04e-03 5.94e-03 0.19400 -0.037500 -0.190000 4.71e-01 2.54e-04
Caspase activation via extrinsic apoptotic signalling pathway 25 1.39e-01 2.19e-01 0.19400 -0.181000 0.068300 1.17e-01 5.54e-01
Mitochondrial iron-sulfur cluster biogenesis 12 6.05e-01 6.68e-01 0.19300 -0.119000 -0.152000 4.76e-01 3.62e-01
RHO GTPases activate PKNs 34 2.42e-01 3.30e-01 0.19300 -0.151000 -0.119000 1.27e-01 2.28e-01
APC/C-mediated degradation of cell cycle proteins 84 2.06e-02 5.48e-02 0.19200 -0.080800 -0.175000 2.00e-01 5.68e-03
Regulation of mitotic cell cycle 84 2.06e-02 5.48e-02 0.19200 -0.080800 -0.175000 2.00e-01 5.68e-03
DNA Double Strand Break Response 41 1.76e-01 2.60e-01 0.19200 -0.111000 -0.157000 2.20e-01 8.12e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 22 4.00e-01 4.91e-01 0.19200 -0.153000 -0.115000 2.13e-01 3.50e-01
SARS-CoV-2 Infection 249 4.02e-05 4.48e-04 0.19200 -0.124000 -0.146000 7.71e-04 6.97e-05
Autodegradation of the E3 ubiquitin ligase COP1 50 7.36e-02 1.35e-01 0.19200 -0.046900 -0.186000 5.66e-01 2.31e-02
Programmed Cell Death 190 4.52e-04 3.11e-03 0.19100 -0.146000 -0.124000 5.29e-04 3.29e-03
APC/C:Cdc20 mediated degradation of mitotic proteins 72 3.77e-02 8.19e-02 0.19100 -0.081100 -0.173000 2.34e-01 1.11e-02
IGF1R signaling cascade 50 1.11e-01 1.85e-01 0.19100 -0.091100 -0.168000 2.65e-01 3.99e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 25 3.20e-01 4.11e-01 0.19100 -0.173000 -0.079700 1.34e-01 4.90e-01
Downstream signaling events of B Cell Receptor (BCR) 78 3.11e-02 7.27e-02 0.19100 -0.085700 -0.170000 1.91e-01 9.33e-03
Reactions specific to the complex N-glycan synthesis pathway 10 6.53e-01 7.08e-01 0.19100 -0.100000 -0.162000 5.83e-01 3.75e-01
Processive synthesis on the C-strand of the telomere 19 4.48e-01 5.31e-01 0.19100 -0.161000 -0.102000 2.25e-01 4.40e-01
Infectious disease 860 1.91e-15 1.38e-13 0.19000 -0.111000 -0.154000 3.02e-08 2.13e-14
Neurotransmitter receptors and postsynaptic signal transmission 174 1.01e-03 5.83e-03 0.18900 -0.125000 -0.142000 4.43e-03 1.22e-03
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 51 1.17e-01 1.93e-01 0.18900 -0.099000 -0.161000 2.21e-01 4.62e-02
Pyruvate metabolism and Citric Acid (TCA) cycle 50 1.33e-01 2.11e-01 0.18900 -0.117000 -0.149000 1.52e-01 6.91e-02
Glucose metabolism 85 3.45e-02 7.81e-02 0.18900 -0.140000 -0.127000 2.61e-02 4.22e-02
Negative regulation of FGFR4 signaling 30 2.21e-01 3.07e-01 0.18900 -0.182000 -0.047800 8.36e-02 6.51e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 73 3.84e-02 8.32e-02 0.18900 -0.077800 -0.172000 2.50e-01 1.11e-02
RNA Polymerase I Transcription Initiation 42 1.88e-01 2.71e-01 0.18900 -0.145000 -0.120000 1.03e-01 1.78e-01
Prostacyclin signalling through prostacyclin receptor 19 4.66e-01 5.48e-01 0.18800 -0.113000 -0.151000 3.95e-01 2.55e-01
Metabolism of RNA 600 3.25e-12 1.76e-10 0.18800 -0.071800 -0.174000 2.68e-03 3.97e-13
IRF3-mediated induction of type I IFN 11 4.32e-01 5.21e-01 0.18800 0.078500 -0.171000 6.52e-01 3.27e-01
KEAP1-NFE2L2 pathway 102 1.67e-02 4.69e-02 0.18800 -0.109000 -0.153000 5.65e-02 7.71e-03
SCF-beta-TrCP mediated degradation of Emi1 53 8.07e-02 1.45e-01 0.18800 -0.059300 -0.178000 4.55e-01 2.49e-02
Metabolism of non-coding RNA 48 1.12e-01 1.87e-01 0.18700 -0.069000 -0.174000 4.08e-01 3.68e-02
snRNP Assembly 48 1.12e-01 1.87e-01 0.18700 -0.069000 -0.174000 4.08e-01 3.68e-02
Regulation of expression of SLITs and ROBOs 158 2.63e-04 2.05e-03 0.18700 -0.032500 -0.184000 4.82e-01 6.55e-05
The role of GTSE1 in G2/M progression after G2 checkpoint 58 5.48e-02 1.10e-01 0.18700 -0.043800 -0.182000 5.64e-01 1.67e-02
IL-6-type cytokine receptor ligand interactions 17 2.78e-01 3.64e-01 0.18700 0.170000 -0.077600 2.25e-01 5.80e-01
SARS-CoV-2 modulates autophagy 11 6.04e-01 6.68e-01 0.18700 -0.065500 -0.175000 7.07e-01 3.16e-01
Synthesis of DNA 109 7.30e-03 2.59e-02 0.18600 -0.066800 -0.174000 2.28e-01 1.72e-03
FGFR4 ligand binding and activation 13 5.71e-01 6.40e-01 0.18600 -0.079900 -0.168000 6.18e-01 2.94e-01
Interleukin-1 family signaling 126 4.73e-03 1.87e-02 0.18600 -0.082300 -0.167000 1.11e-01 1.22e-03
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 16 4.93e-01 5.73e-01 0.18500 -0.172000 -0.069700 2.35e-01 6.29e-01
Interconversion of nucleotide di- and triphosphates 24 4.02e-01 4.93e-01 0.18500 -0.135000 -0.126000 2.51e-01 2.86e-01
Cellular response to hypoxia 70 3.41e-02 7.75e-02 0.18500 -0.046200 -0.179000 5.04e-01 9.68e-03
Cellular responses to stress 654 1.76e-11 8.36e-10 0.18400 -0.105000 -0.152000 4.62e-06 3.92e-11
Sialic acid metabolism 33 8.43e-02 1.50e-01 0.18400 0.087000 -0.163000 3.87e-01 1.06e-01
Metabolism of proteins 1709 1.20e-28 2.60e-26 0.18400 -0.087600 -0.162000 1.96e-09 1.10e-28
Signaling by EGFR 48 1.63e-01 2.45e-01 0.18400 -0.119000 -0.141000 1.55e-01 9.18e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 5.64e-01 6.35e-01 0.18400 0.162000 0.086900 2.94e-01 5.73e-01
PI3K Cascade 42 2.02e-01 2.86e-01 0.18400 -0.113000 -0.145000 2.06e-01 1.04e-01
Josephin domain DUBs 11 4.94e-01 5.74e-01 0.18400 -0.181000 0.029800 2.98e-01 8.64e-01
Lysine catabolism 10 6.67e-01 7.18e-01 0.18300 -0.088100 -0.161000 6.30e-01 3.79e-01
Pyruvate metabolism 27 3.53e-01 4.44e-01 0.18300 -0.151000 -0.103000 1.73e-01 3.56e-01
CDK-mediated phosphorylation and removal of Cdc6 69 6.30e-02 1.21e-01 0.18300 -0.087400 -0.160000 2.10e-01 2.13e-02
Gap junction assembly 18 4.81e-01 5.63e-01 0.18300 0.083600 0.162000 5.39e-01 2.33e-01
SHC1 events in ERBB4 signaling 14 5.96e-01 6.61e-01 0.18200 -0.132000 -0.126000 3.93e-01 4.14e-01
Triglyceride metabolism 31 2.35e-01 3.23e-01 0.18200 -0.176000 -0.047400 9.01e-02 6.48e-01
Signalling to ERKs 34 2.46e-01 3.33e-01 0.18200 -0.078000 -0.165000 4.31e-01 9.68e-02
SARS-CoV-1 Infection 49 1.24e-01 2.01e-01 0.18200 -0.169000 -0.068800 4.13e-02 4.05e-01
Autophagy 112 1.66e-02 4.68e-02 0.18100 -0.118000 -0.138000 3.10e-02 1.18e-02
Macroautophagy 100 2.42e-02 6.01e-02 0.18100 -0.108000 -0.146000 6.30e-02 1.17e-02
Influenza Infection 147 2.43e-03 1.13e-02 0.18100 -0.074200 -0.165000 1.21e-01 5.60e-04
Lagging Strand Synthesis 19 3.47e-01 4.37e-01 0.18100 -0.000536 -0.181000 9.97e-01 1.72e-01
Vif-mediated degradation of APOBEC3G 50 5.67e-02 1.12e-01 0.18100 0.008450 -0.180000 9.18e-01 2.74e-02
VLDLR internalisation and degradation 16 5.54e-01 6.26e-01 0.18100 -0.109000 -0.144000 4.50e-01 3.19e-01
Cellular responses to stimuli 668 4.10e-11 1.78e-09 0.18000 -0.107000 -0.145000 2.40e-06 1.67e-10
Nonhomologous End-Joining (NHEJ) 30 2.31e-01 3.18e-01 0.18000 -0.031200 -0.178000 7.68e-01 9.22e-02
DAP12 signaling 27 1.35e-01 2.12e-01 0.18000 0.110000 -0.143000 3.24e-01 1.98e-01
Late endosomal microautophagy 29 1.57e-01 2.40e-01 0.18000 -0.175000 0.040200 1.02e-01 7.08e-01
Signal amplification 31 3.10e-01 4.01e-01 0.18000 -0.095000 -0.153000 3.60e-01 1.42e-01
IRS-related events triggered by IGF1R 49 1.52e-01 2.35e-01 0.17900 -0.088500 -0.156000 2.84e-01 5.87e-02
TAK1-dependent IKK and NF-kappa-B activation 23 4.41e-01 5.29e-01 0.17900 -0.125000 -0.128000 2.98e-01 2.88e-01
Telomere Extension By Telomerase 21 4.73e-01 5.56e-01 0.17900 -0.116000 -0.136000 3.57e-01 2.82e-01
NOTCH2 intracellular domain regulates transcription 11 6.70e-01 7.19e-01 0.17800 -0.104000 -0.145000 5.50e-01 4.05e-01
Cell junction organization 78 6.31e-02 1.21e-01 0.17800 -0.117000 -0.135000 7.34e-02 3.99e-02
Signaling by MET 66 8.50e-02 1.51e-01 0.17800 -0.092600 -0.152000 1.93e-01 3.23e-02
Regulation of lipid metabolism by PPARalpha 115 7.40e-03 2.61e-02 0.17800 -0.055700 -0.169000 3.02e-01 1.74e-03
Complex I biogenesis 44 5.36e-02 1.08e-01 0.17800 0.063400 -0.166000 4.67e-01 5.66e-02
Binding and Uptake of Ligands by Scavenger Receptors 39 2.47e-01 3.34e-01 0.17800 0.105000 0.143000 2.54e-01 1.22e-01
Bicarbonate transporters 10 5.13e-01 5.91e-01 0.17800 0.065400 -0.165000 7.20e-01 3.66e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 1.08e-01 1.81e-01 0.17700 -0.056800 -0.168000 4.74e-01 3.47e-02
COPI-independent Golgi-to-ER retrograde traffic 34 1.34e-01 2.11e-01 0.17700 0.027900 -0.175000 7.79e-01 7.80e-02
Toll-like Receptor Cascades 138 8.49e-03 2.91e-02 0.17700 -0.120000 -0.130000 1.46e-02 8.62e-03
Autodegradation of Cdh1 by Cdh1:APC/C 60 9.04e-02 1.58e-01 0.17700 -0.067700 -0.163000 3.65e-01 2.87e-02
COPII-mediated vesicle transport 63 1.08e-01 1.81e-01 0.17700 -0.141000 -0.106000 5.24e-02 1.45e-01
Cellular response to chemical stress 182 2.02e-03 9.93e-03 0.17600 -0.117000 -0.131000 6.71e-03 2.23e-03
Negative regulation of MET activity 20 5.05e-01 5.84e-01 0.17500 -0.130000 -0.118000 3.14e-01 3.63e-01
Meiosis 53 9.76e-02 1.68e-01 0.17500 -0.041500 -0.170000 6.02e-01 3.21e-02
Influenza Viral RNA Transcription and Replication 128 3.80e-03 1.57e-02 0.17500 -0.041500 -0.170000 4.18e-01 9.09e-04
Maturation of nucleoprotein 11 6.90e-01 7.35e-01 0.17400 -0.126000 -0.120000 4.68e-01 4.90e-01
PPARA activates gene expression 113 1.02e-02 3.31e-02 0.17400 -0.054700 -0.165000 3.16e-01 2.46e-03
Signaling by ERBB4 56 1.47e-01 2.28e-01 0.17400 -0.140000 -0.103000 7.02e-02 1.82e-01
Iron uptake and transport 56 1.52e-01 2.35e-01 0.17400 -0.131000 -0.114000 8.96e-02 1.40e-01
CD28 co-stimulation 32 1.76e-01 2.60e-01 0.17400 0.013700 -0.173000 8.94e-01 9.01e-02
Pyrimidine salvage 10 6.69e-01 7.18e-01 0.17300 0.164000 0.056600 3.70e-01 7.57e-01
Ion homeostasis 50 1.82e-01 2.65e-01 0.17300 -0.102000 -0.140000 2.13e-01 8.68e-02
G beta:gamma signalling through BTK 17 5.16e-01 5.94e-01 0.17300 -0.063100 -0.161000 6.52e-01 2.51e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 9.29e-02 1.61e-01 0.17300 -0.007010 -0.173000 9.33e-01 3.85e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 30 1.64e-01 2.47e-01 0.17200 0.047400 -0.166000 6.53e-01 1.16e-01
Inwardly rectifying K+ channels 35 3.14e-01 4.05e-01 0.17200 -0.115000 -0.129000 2.41e-01 1.88e-01
Semaphorin interactions 60 5.48e-02 1.10e-01 0.17200 -0.010600 -0.172000 8.87e-01 2.13e-02
Integrin cell surface interactions 66 1.12e-01 1.87e-01 0.17200 -0.111000 -0.132000 1.19e-01 6.41e-02
Interleukin-7 signaling 21 4.57e-01 5.40e-01 0.17200 -0.071000 -0.157000 5.73e-01 2.14e-01
Regulation of innate immune responses to cytosolic DNA 14 4.01e-01 4.92e-01 0.17200 -0.151000 0.081600 3.27e-01 5.97e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 4.45e-01 5.31e-01 0.17200 0.137000 -0.104000 4.13e-01 5.31e-01
RHO GTPases Activate NADPH Oxidases 22 4.83e-01 5.65e-01 0.17100 0.107000 0.134000 3.86e-01 2.77e-01
IRS-mediated signalling 46 2.21e-01 3.07e-01 0.17100 -0.109000 -0.132000 2.02e-01 1.21e-01
GABA receptor activation 56 1.58e-01 2.41e-01 0.17100 -0.105000 -0.135000 1.75e-01 8.04e-02
Inflammasomes 21 3.85e-01 4.76e-01 0.17100 -0.170000 -0.021900 1.79e-01 8.62e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 1.02e-01 1.73e-01 0.17100 -0.033200 -0.168000 6.76e-01 3.49e-02
RHO GTPases Activate ROCKs 19 5.41e-01 6.14e-01 0.17100 -0.123000 -0.118000 3.53e-01 3.72e-01
DAP12 interactions 39 1.55e-01 2.38e-01 0.17100 0.170000 0.008770 6.57e-02 9.25e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 106 6.54e-03 2.36e-02 0.17100 -0.009880 -0.170000 8.60e-01 2.46e-03
Nonsense-Mediated Decay (NMD) 106 6.54e-03 2.36e-02 0.17100 -0.009880 -0.170000 8.60e-01 2.46e-03
Biological oxidations 205 5.61e-04 3.72e-03 0.17000 0.067700 0.156000 9.47e-02 1.16e-04
Metabolism of carbohydrates 265 1.80e-04 1.52e-03 0.17000 -0.137000 -0.101000 1.23e-04 4.71e-03
Activation of NF-kappaB in B cells 64 4.99e-02 1.03e-01 0.17000 -0.012400 -0.170000 8.64e-01 1.89e-02
Signaling by SCF-KIT 43 2.18e-01 3.04e-01 0.17000 -0.075200 -0.152000 3.94e-01 8.45e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 4.90e-01 5.72e-01 0.17000 -0.158000 -0.061200 2.33e-01 6.44e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 4.90e-01 5.72e-01 0.17000 -0.158000 -0.061200 2.33e-01 6.44e-01
Ribosomal scanning and start codon recognition 54 4.46e-02 9.40e-02 0.16900 0.045000 -0.163000 5.67e-01 3.81e-02
CASP8 activity is inhibited 11 5.86e-01 6.53e-01 0.16900 0.000411 0.169000 9.98e-01 3.32e-01
Dimerization of procaspase-8 11 5.86e-01 6.53e-01 0.16900 0.000411 0.169000 9.98e-01 3.32e-01
Regulation by c-FLIP 11 5.86e-01 6.53e-01 0.16900 0.000411 0.169000 9.98e-01 3.32e-01
Cap-dependent Translation Initiation 112 5.28e-03 2.02e-02 0.16900 -0.007630 -0.168000 8.89e-01 2.07e-03
Eukaryotic Translation Initiation 112 5.28e-03 2.02e-02 0.16900 -0.007630 -0.168000 8.89e-01 2.07e-03
Cargo recognition for clathrin-mediated endocytosis 97 3.48e-02 7.83e-02 0.16900 -0.076800 -0.150000 1.91e-01 1.06e-02
Transferrin endocytosis and recycling 29 3.45e-01 4.36e-01 0.16800 -0.156000 -0.062600 1.45e-01 5.59e-01
Vitamin D (calciferol) metabolism 12 5.47e-01 6.20e-01 0.16800 -0.168000 0.009190 3.14e-01 9.56e-01
Stabilization of p53 55 1.14e-01 1.89e-01 0.16700 -0.042700 -0.162000 5.83e-01 3.80e-02
Regulation of gene expression by Hypoxia-inducible Factor 11 6.61e-01 7.12e-01 0.16700 -0.053300 -0.158000 7.59e-01 3.63e-01
Phase I - Functionalization of compounds 97 9.60e-03 3.22e-02 0.16700 -0.003140 0.167000 9.57e-01 4.57e-03
N-Glycan antennae elongation 15 5.54e-01 6.26e-01 0.16700 -0.161000 -0.041600 2.79e-01 7.80e-01
RHOG GTPase cycle 64 4.34e-02 9.19e-02 0.16600 0.009590 -0.166000 8.94e-01 2.16e-02
Transport of inorganic cations/anions and amino acids/oligopeptides 100 4.81e-02 1.00e-01 0.16500 -0.123000 -0.111000 3.40e-02 5.50e-02
Plasma lipoprotein assembly 19 5.31e-01 6.05e-01 0.16500 0.076600 0.147000 5.63e-01 2.69e-01
Polo-like kinase mediated events 16 5.35e-01 6.08e-01 0.16500 -0.039100 -0.160000 7.87e-01 2.67e-01
Cross-presentation of soluble exogenous antigens (endosomes) 48 6.25e-02 1.21e-01 0.16500 0.061400 -0.153000 4.62e-01 6.61e-02
GRB2 events in EGFR signaling 12 6.81e-01 7.27e-01 0.16500 0.084100 0.141000 6.14e-01 3.96e-01
CLEC7A (Dectin-1) signaling 94 5.95e-02 1.17e-01 0.16400 -0.107000 -0.125000 7.39e-02 3.64e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 30 3.62e-01 4.52e-01 0.16400 -0.149000 -0.068000 1.57e-01 5.19e-01
APC/C:Cdc20 mediated degradation of Securin 64 1.31e-01 2.08e-01 0.16400 -0.082800 -0.141000 2.52e-01 5.05e-02
NIK–>noncanonical NF-kB signaling 57 1.16e-01 1.92e-01 0.16300 -0.040900 -0.158000 5.94e-01 3.90e-02
Basigin interactions 24 3.49e-01 4.40e-01 0.16300 -0.163000 -0.008700 1.67e-01 9.41e-01
PERK regulates gene expression 30 1.87e-01 2.70e-01 0.16300 0.059000 -0.152000 5.76e-01 1.50e-01
NOTCH3 Intracellular Domain Regulates Transcription 24 3.73e-01 4.62e-01 0.16300 -0.020800 -0.161000 8.60e-01 1.72e-01
Removal of the Flap Intermediate from the C-strand 17 6.07e-01 6.70e-01 0.16200 -0.124000 -0.104000 3.76e-01 4.57e-01
Metabolism of amine-derived hormones 17 5.21e-01 5.98e-01 0.16200 0.033600 0.158000 8.10e-01 2.58e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 5.89e-01 6.55e-01 0.16200 -0.080900 -0.140000 5.64e-01 3.17e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 4.44e-01 5.31e-01 0.16200 -0.060100 -0.150000 6.10e-01 2.03e-01
Meiotic recombination 26 3.35e-01 4.25e-01 0.16100 -0.012700 -0.161000 9.11e-01 1.55e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 55 6.84e-02 1.29e-01 0.16100 0.022800 -0.160000 7.70e-01 4.04e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 87 6.11e-02 1.19e-01 0.16100 -0.069900 -0.145000 2.60e-01 1.92e-02
TRP channels 24 3.86e-01 4.76e-01 0.16100 -0.159000 -0.024400 1.77e-01 8.36e-01
Degradation of DVL 55 1.02e-01 1.73e-01 0.16100 -0.013600 -0.160000 8.62e-01 3.97e-02
Diseases of metabolism 225 1.15e-03 6.38e-03 0.16100 -0.137000 -0.084100 4.00e-04 2.97e-02
FLT3 signaling in disease 28 4.42e-01 5.30e-01 0.16000 -0.129000 -0.094900 2.37e-01 3.85e-01
Metabolism of nucleotides 87 8.31e-02 1.48e-01 0.16000 -0.103000 -0.123000 9.79e-02 4.77e-02
Bile acid and bile salt metabolism 43 2.85e-01 3.72e-01 0.16000 0.130000 0.093200 1.40e-01 2.90e-01
Assembly of active LPL and LIPC lipase complexes 16 4.47e-01 5.31e-01 0.16000 -0.156000 0.035700 2.81e-01 8.05e-01
TICAM1, RIP1-mediated IKK complex recruitment 18 5.79e-01 6.48e-01 0.16000 -0.138000 -0.080000 3.10e-01 5.57e-01
Glutathione conjugation 37 3.33e-01 4.23e-01 0.15900 0.081600 0.136000 3.90e-01 1.52e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 32 4.08e-01 4.99e-01 0.15900 -0.119000 -0.105000 2.45e-01 3.04e-01
Signaling by Insulin receptor 74 1.28e-01 2.05e-01 0.15800 -0.110000 -0.114000 1.02e-01 9.00e-02
Mitochondrial calcium ion transport 16 4.73e-01 5.56e-01 0.15800 0.021200 -0.157000 8.83e-01 2.77e-01
Meiotic synapsis 29 3.47e-01 4.37e-01 0.15800 -0.034000 -0.155000 7.51e-01 1.50e-01
Intra-Golgi traffic 41 2.47e-01 3.34e-01 0.15800 -0.047700 -0.151000 5.97e-01 9.45e-02
Formation of the ternary complex, and subsequently, the 43S complex 47 9.86e-02 1.69e-01 0.15800 0.035700 -0.154000 6.72e-01 6.75e-02
Regulated Necrosis 52 5.07e-02 1.04e-01 0.15800 -0.119000 0.103000 1.36e-01 1.97e-01
MASTL Facilitates Mitotic Progression 10 6.26e-01 6.84e-01 0.15800 0.022600 -0.156000 9.01e-01 3.92e-01
Aggrephagy 23 5.21e-01 5.98e-01 0.15800 -0.127000 -0.093400 2.91e-01 4.38e-01
PTEN Regulation 141 2.10e-02 5.48e-02 0.15700 -0.107000 -0.116000 2.87e-02 1.76e-02
Signaling by the B Cell Receptor (BCR) 105 3.61e-02 7.97e-02 0.15700 -0.061000 -0.145000 2.80e-01 1.02e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 70 1.34e-01 2.12e-01 0.15700 -0.085400 -0.132000 2.17e-01 5.59e-02
STING mediated induction of host immune responses 13 4.80e-01 5.63e-01 0.15700 0.120000 -0.101000 4.54e-01 5.30e-01
RAB geranylgeranylation 54 1.07e-01 1.80e-01 0.15600 -0.156000 -0.001080 4.70e-02 9.89e-01
Constitutive Signaling by Aberrant PI3K in Cancer 75 1.29e-01 2.06e-01 0.15600 -0.093800 -0.124000 1.60e-01 6.32e-02
G-protein beta:gamma signalling 30 4.09e-01 4.99e-01 0.15500 -0.068800 -0.139000 5.14e-01 1.86e-01
Acyl chain remodelling of PC 26 2.39e-01 3.28e-01 0.15500 -0.125000 0.092400 2.70e-01 4.15e-01
G beta:gamma signalling through PI3Kgamma 25 4.85e-01 5.67e-01 0.15500 -0.075600 -0.136000 5.13e-01 2.40e-01
Keratan sulfate degradation 10 6.68e-01 7.18e-01 0.15500 0.004540 0.155000 9.80e-01 3.95e-01
SLC transporter disorders 91 5.74e-02 1.14e-01 0.15500 -0.145000 -0.055300 1.69e-02 3.62e-01
Pyroptosis 25 3.15e-01 4.06e-01 0.15500 -0.028900 0.152000 8.03e-01 1.88e-01
Extracellular matrix organization 273 7.08e-04 4.48e-03 0.15500 -0.096300 -0.121000 6.20e-03 5.84e-04
Translation initiation complex formation 54 7.76e-02 1.41e-01 0.15400 0.038100 -0.149000 6.28e-01 5.76e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 5.98e-01 6.63e-01 0.15400 0.139000 -0.065900 4.47e-01 7.18e-01
Mucopolysaccharidoses 10 6.50e-01 7.05e-01 0.15300 -0.152000 0.016500 4.04e-01 9.28e-01
Mitochondrial translation 92 3.75e-02 8.18e-02 0.15300 -0.022600 -0.151000 7.07e-01 1.22e-02
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 20 5.71e-01 6.40e-01 0.15300 -0.073300 -0.134000 5.70e-01 3.01e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 20 5.71e-01 6.40e-01 0.15300 -0.073300 -0.134000 5.70e-01 3.01e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 20 5.71e-01 6.40e-01 0.15300 -0.073300 -0.134000 5.70e-01 3.01e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 20 5.71e-01 6.40e-01 0.15300 -0.073300 -0.134000 5.70e-01 3.01e-01
Impaired BRCA2 binding to PALB2 20 5.71e-01 6.40e-01 0.15300 -0.073300 -0.134000 5.70e-01 3.01e-01
Cellular response to heat stress 93 9.25e-02 1.61e-01 0.15200 -0.105000 -0.110000 7.97e-02 6.70e-02
Smooth Muscle Contraction 39 2.48e-01 3.34e-01 0.15200 -0.019700 -0.151000 8.32e-01 1.04e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 3.05e-01 3.95e-01 0.15100 0.037300 -0.147000 7.42e-01 1.95e-01
ADP signalling through P2Y purinoceptor 1 25 5.28e-01 6.03e-01 0.15100 -0.114000 -0.098900 3.22e-01 3.92e-01
TP53 Regulates Transcription of Cell Death Genes 41 3.22e-01 4.13e-01 0.15100 -0.071000 -0.133000 4.32e-01 1.39e-01
Synthesis, secretion, and deacylation of Ghrelin 18 5.22e-01 5.99e-01 0.15100 -0.016100 -0.150000 9.06e-01 2.70e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 99 6.00e-02 1.17e-01 0.15100 -0.062900 -0.137000 2.80e-01 1.85e-02
The phototransduction cascade 31 4.47e-01 5.31e-01 0.15100 0.123000 0.086500 2.34e-01 4.05e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 37 3.94e-01 4.84e-01 0.15100 -0.106000 -0.107000 2.65e-01 2.59e-01
Glycogen synthesis 14 6.68e-01 7.18e-01 0.15000 -0.138000 -0.059600 3.71e-01 7.00e-01
Triglyceride biosynthesis 12 5.58e-01 6.29e-01 0.15000 -0.064400 0.135000 6.99e-01 4.18e-01
SRP-dependent cotranslational protein targeting to membrane 105 2.78e-02 6.70e-02 0.14900 -0.019400 -0.147000 7.31e-01 9.14e-03
Inhibition of replication initiation of damaged DNA by RB1/E2F1 11 7.34e-01 7.74e-01 0.14800 -0.058300 -0.136000 7.38e-01 4.33e-01
Respiratory electron transport 81 3.51e-02 7.85e-02 0.14800 0.022300 -0.147000 7.29e-01 2.26e-02
Tight junction interactions 28 2.76e-01 3.64e-01 0.14800 -0.139000 0.050800 2.03e-01 6.42e-01
Nuclear events stimulated by ALK signaling in cancer 18 6.21e-01 6.80e-01 0.14800 -0.130000 -0.070000 3.38e-01 6.07e-01
SARS-CoV-2-host interactions 171 1.29e-02 3.88e-02 0.14800 -0.076600 -0.126000 8.42e-02 4.43e-03
Nucleotide-like (purinergic) receptors 12 5.51e-01 6.24e-01 0.14700 -0.114000 0.093500 4.96e-01 5.75e-01
Cell surface interactions at the vascular wall 127 2.98e-02 7.04e-02 0.14700 0.056100 0.136000 2.75e-01 8.17e-03
G beta:gamma signalling through CDC42 19 5.92e-01 6.58e-01 0.14700 -0.056700 -0.135000 6.69e-01 3.07e-01
Amino acids regulate mTORC1 43 2.69e-01 3.58e-01 0.14700 -0.036000 -0.142000 6.83e-01 1.07e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 5.24e-01 6.00e-01 0.14600 -0.144000 0.023300 3.18e-01 8.72e-01
Gene Silencing by RNA 73 5.69e-02 1.13e-01 0.14600 0.017300 -0.145000 7.98e-01 3.23e-02
Caspase activation via Death Receptors in the presence of ligand 16 6.10e-01 6.73e-01 0.14600 0.031800 0.142000 8.26e-01 3.24e-01
Nicotinate metabolism 25 5.42e-01 6.14e-01 0.14600 0.121000 0.080200 2.93e-01 4.88e-01
N-glycan antennae elongation in the medial/trans-Golgi 26 5.27e-01 6.03e-01 0.14500 -0.123000 -0.075800 2.76e-01 5.03e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 105 1.61e-02 4.55e-02 0.14500 0.021700 -0.143000 7.01e-01 1.13e-02
Metabolism of lipids 664 3.24e-07 7.13e-06 0.14500 -0.107000 -0.097200 2.65e-06 2.00e-05
IKK complex recruitment mediated by RIP1 22 5.92e-01 6.58e-01 0.14400 -0.117000 -0.084100 3.40e-01 4.95e-01
Ion channel transport 157 2.67e-02 6.49e-02 0.14400 -0.111000 -0.092100 1.67e-02 4.64e-02
Keratan sulfate biosynthesis 25 3.23e-01 4.13e-01 0.14400 -0.129000 0.064600 2.66e-01 5.76e-01
The citric acid (TCA) cycle and respiratory electron transport 132 2.40e-02 6.01e-02 0.14400 -0.042000 -0.138000 4.05e-01 6.38e-03
Collagen degradation 35 4.11e-01 5.00e-01 0.14300 -0.129000 -0.061400 1.86e-01 5.29e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 2.34e-01 3.23e-01 0.14300 0.009370 -0.142000 9.18e-01 1.20e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 7.76e-01 8.09e-01 0.14200 -0.115000 -0.083500 5.08e-01 6.32e-01
Other semaphorin interactions 18 4.34e-01 5.22e-01 0.14200 0.098300 -0.102000 4.70e-01 4.52e-01
activated TAK1 mediates p38 MAPK activation 14 7.07e-01 7.50e-01 0.14100 -0.127000 -0.061600 4.10e-01 6.90e-01
FGFR1c ligand binding and activation 11 7.80e-01 8.12e-01 0.14100 -0.085400 -0.112000 6.24e-01 5.19e-01
Signaling by activated point mutants of FGFR1 11 7.80e-01 8.12e-01 0.14100 -0.085400 -0.112000 6.24e-01 5.19e-01
Mitochondrial translation initiation 86 7.38e-02 1.35e-01 0.14100 -0.021600 -0.139000 7.29e-01 2.54e-02
RHO GTPases activate PAKs 19 4.29e-01 5.17e-01 0.14100 0.118000 -0.076500 3.73e-01 5.64e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 6.88e-01 7.33e-01 0.14100 -0.104000 -0.094300 4.56e-01 5.01e-01
Fanconi Anemia Pathway 31 4.91e-01 5.72e-01 0.14000 -0.075700 -0.118000 4.66e-01 2.55e-01
Mitochondrial translation termination 86 6.46e-02 1.24e-01 0.14000 -0.007780 -0.139000 9.01e-01 2.55e-02
Interleukin-2 signaling 10 6.48e-01 7.03e-01 0.13900 0.071300 -0.120000 6.96e-01 5.12e-01
Killing mechanisms 11 6.96e-01 7.39e-01 0.13900 -0.000972 -0.139000 9.96e-01 4.24e-01
WNT5:FZD7-mediated leishmania damping 11 6.96e-01 7.39e-01 0.13900 -0.000972 -0.139000 9.96e-01 4.24e-01
Aquaporin-mediated transport 51 3.13e-01 4.04e-01 0.13800 -0.120000 -0.069200 1.38e-01 3.93e-01
Acyl chain remodelling of PG 18 4.86e-01 5.68e-01 0.13800 -0.047100 0.130000 7.30e-01 3.39e-01
Eukaryotic Translation Elongation 88 7.21e-02 1.32e-01 0.13800 -0.016000 -0.137000 7.96e-01 2.61e-02
Aflatoxin activation and detoxification 20 4.42e-01 5.30e-01 0.13800 -0.056300 0.126000 6.63e-01 3.31e-01
Dectin-1 mediated noncanonical NF-kB signaling 60 2.14e-01 2.99e-01 0.13800 -0.042100 -0.131000 5.73e-01 7.94e-02
Arachidonic acid metabolism 55 3.11e-01 4.02e-01 0.13800 0.108000 0.085400 1.67e-01 2.73e-01
Mitophagy 26 5.79e-01 6.48e-01 0.13700 -0.103000 -0.091100 3.64e-01 4.21e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 86 5.24e-02 1.06e-01 0.13700 0.013100 -0.137000 8.33e-01 2.84e-02
Cytochrome P450 - arranged by substrate type 63 7.34e-02 1.34e-01 0.13700 -0.068700 0.118000 3.46e-01 1.05e-01
PINK1-PRKN Mediated Mitophagy 20 5.77e-01 6.47e-01 0.13600 -0.026600 -0.134000 8.37e-01 3.01e-01
Cell recruitment (pro-inflammatory response) 25 3.63e-01 4.52e-01 0.13600 -0.062500 0.121000 5.89e-01 2.96e-01
Purinergic signaling in leishmaniasis infection 25 3.63e-01 4.52e-01 0.13600 -0.062500 0.121000 5.89e-01 2.96e-01
ER-Phagosome pathway 87 1.21e-01 1.98e-01 0.13600 -0.046800 -0.127000 4.51e-01 4.01e-02
Cellular response to starvation 137 2.41e-02 6.01e-02 0.13600 -0.025300 -0.133000 6.09e-01 7.15e-03
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 47 2.72e-01 3.60e-01 0.13600 -0.134000 -0.022500 1.13e-01 7.89e-01
Regulation of HSF1-mediated heat shock response 76 2.09e-01 2.94e-01 0.13500 -0.106000 -0.084400 1.10e-01 2.03e-01
Organic anion transporters 10 7.37e-01 7.76e-01 0.13500 -0.135000 -0.003400 4.60e-01 9.85e-01
ABC transporters in lipid homeostasis 16 5.58e-01 6.29e-01 0.13400 -0.037600 0.129000 7.95e-01 3.73e-01
Removal of the Flap Intermediate 13 6.11e-01 6.73e-01 0.13300 0.051800 -0.123000 7.46e-01 4.43e-01
Cytosolic sulfonation of small molecules 22 6.51e-01 7.06e-01 0.13200 0.098600 0.088100 4.23e-01 4.74e-01
L13a-mediated translational silencing of Ceruloplasmin expression 104 3.04e-02 7.14e-02 0.13200 0.026100 -0.129000 6.45e-01 2.28e-02
GRB2 events in ERBB2 signaling 16 6.01e-01 6.65e-01 0.13200 -0.131000 0.014100 3.64e-01 9.22e-01
Branched-chain amino acid catabolism 20 6.54e-01 7.08e-01 0.13100 -0.056000 -0.118000 6.65e-01 3.61e-01
Formation of a pool of free 40S subunits 95 4.50e-02 9.46e-02 0.13100 0.023300 -0.129000 6.94e-01 3.03e-02
Acyl chain remodelling of PS 21 5.41e-01 6.14e-01 0.13000 -0.001790 0.130000 9.89e-01 3.02e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 94 8.95e-02 1.57e-01 0.13000 -0.020300 -0.128000 7.34e-01 3.14e-02
p38MAPK events 13 7.60e-01 7.95e-01 0.13000 -0.118000 -0.054300 4.62e-01 7.35e-01
Plasma lipoprotein clearance 36 5.07e-01 5.86e-01 0.12900 -0.080100 -0.102000 4.06e-01 2.91e-01
HDL remodeling 10 8.03e-01 8.32e-01 0.12900 -0.121000 -0.045900 5.08e-01 8.01e-01
SLC-mediated transmembrane transport 235 2.39e-03 1.11e-02 0.12900 -0.128000 -0.014800 7.50e-04 6.97e-01
Mitochondrial translation elongation 86 1.02e-01 1.73e-01 0.12800 -0.007700 -0.127000 9.02e-01 4.13e-02
RAC3 GTPase cycle 78 2.46e-01 3.33e-01 0.12700 -0.087000 -0.093200 1.84e-01 1.55e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 7.23e-01 7.63e-01 0.12700 -0.092800 -0.087200 4.95e-01 5.22e-01
ABC-family proteins mediated transport 97 7.17e-02 1.32e-01 0.12700 -0.002230 -0.127000 9.70e-01 3.05e-02
Sema4D in semaphorin signaling 23 5.20e-01 5.98e-01 0.12700 0.005830 -0.127000 9.61e-01 2.92e-01
SHC1 events in ERBB2 signaling 22 6.75e-01 7.22e-01 0.12700 -0.094200 -0.084900 4.44e-01 4.91e-01
Ion transport by P-type ATPases 51 2.26e-01 3.13e-01 0.12700 0.012200 -0.126000 8.80e-01 1.20e-01
Developmental Biology 986 3.30e-09 1.09e-07 0.12700 -0.046500 -0.118000 1.37e-02 4.30e-10
Chaperone Mediated Autophagy 19 4.97e-01 5.77e-01 0.12600 -0.094700 0.083800 4.75e-01 5.27e-01
GPCR ligand binding 413 1.54e-04 1.35e-03 0.12600 0.039200 0.120000 1.72e-01 2.81e-05
EGFR downregulation 29 4.45e-01 5.31e-01 0.12600 -0.125000 0.006620 2.42e-01 9.51e-01
Erythrocytes take up carbon dioxide and release oxygen 12 6.93e-01 7.37e-01 0.12500 0.026000 -0.122000 8.76e-01 4.63e-01
O2/CO2 exchange in erythrocytes 12 6.93e-01 7.37e-01 0.12500 0.026000 -0.122000 8.76e-01 4.63e-01
Interferon alpha/beta signaling 63 1.45e-01 2.26e-01 0.12500 0.027300 -0.122000 7.08e-01 9.36e-02
Interferon gamma signaling 88 7.20e-02 1.32e-01 0.12500 0.122000 -0.023700 4.73e-02 7.01e-01
The role of Nef in HIV-1 replication and disease pathogenesis 27 4.79e-01 5.61e-01 0.12400 0.006140 -0.124000 9.56e-01 2.64e-01
Insulin receptor recycling 24 6.21e-01 6.80e-01 0.12400 -0.115000 -0.047100 3.30e-01 6.89e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 12 6.57e-01 7.09e-01 0.12400 0.072000 -0.101000 6.66e-01 5.45e-01
Nucleotide catabolism 32 5.38e-01 6.11e-01 0.12400 -0.049900 -0.113000 6.25e-01 2.68e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 12 6.71e-01 7.19e-01 0.12400 -0.111000 0.054000 5.05e-01 7.46e-01
Keratan sulfate/keratin metabolism 30 5.05e-01 5.84e-01 0.12400 -0.121000 -0.022600 2.50e-01 8.30e-01
Inactivation, recovery and regulation of the phototransduction cascade 30 6.00e-01 6.64e-01 0.12300 0.094700 0.079300 3.70e-01 4.52e-01
Signaling by EGFR in Cancer 24 5.30e-01 6.04e-01 0.12300 -0.123000 0.003720 2.96e-01 9.75e-01
Eukaryotic Translation Termination 87 1.17e-01 1.93e-01 0.12300 -0.007460 -0.123000 9.04e-01 4.80e-02
Aspartate and asparagine metabolism 11 8.31e-01 8.57e-01 0.12300 -0.093900 -0.079100 5.90e-01 6.50e-01
Integrin signaling 27 4.43e-01 5.30e-01 0.12300 0.031400 -0.119000 7.77e-01 2.86e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 68 3.25e-01 4.15e-01 0.12200 -0.082700 -0.089900 2.38e-01 2.00e-01
Glyoxylate metabolism and glycine degradation 29 3.91e-01 4.80e-01 0.12100 -0.057100 0.107000 5.95e-01 3.19e-01
Formation of tubulin folding intermediates by CCT/TriC 24 4.98e-01 5.77e-01 0.12100 0.028300 -0.118000 8.11e-01 3.17e-01
Ovarian tumor domain proteases 36 4.13e-01 5.02e-01 0.12000 0.001080 -0.120000 9.91e-01 2.14e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 89 1.12e-01 1.87e-01 0.11900 0.002120 -0.119000 9.72e-01 5.15e-02
ECM proteoglycans 55 4.14e-01 5.03e-01 0.11900 -0.094300 -0.073200 2.26e-01 3.48e-01
Diseases associated with O-glycosylation of proteins 60 3.86e-01 4.76e-01 0.11900 -0.092400 -0.075100 2.16e-01 3.15e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 7.67e-01 8.00e-01 0.11900 -0.082100 -0.085700 5.58e-01 5.41e-01
Downstream TCR signaling 91 6.23e-02 1.21e-01 0.11900 0.051500 -0.107000 3.96e-01 7.81e-02
Adherens junctions interactions 26 4.49e-01 5.32e-01 0.11800 0.054200 -0.105000 6.32e-01 3.52e-01
Scavenging by Class A Receptors 18 6.54e-01 7.08e-01 0.11800 0.118000 0.001880 3.86e-01 9.89e-01
Protein localization 137 8.55e-02 1.52e-01 0.11700 -0.041600 -0.110000 4.01e-01 2.67e-02
Lewis blood group biosynthesis 18 7.19e-01 7.60e-01 0.11700 0.037600 0.111000 7.82e-01 4.17e-01
Transport of small molecules 666 5.73e-05 5.93e-04 0.11700 -0.085400 -0.079700 1.76e-04 4.62e-04
Major pathway of rRNA processing in the nucleolus and cytosol 169 5.34e-02 1.08e-01 0.11700 -0.045200 -0.108000 3.11e-01 1.58e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 7.82e-01 8.13e-01 0.11600 -0.092600 -0.070500 5.21e-01 6.25e-01
Costimulation by the CD28 family 64 1.60e-01 2.42e-01 0.11600 0.107000 -0.044500 1.38e-01 5.38e-01
Purine catabolism 15 6.55e-01 7.08e-01 0.11500 0.042200 -0.107000 7.77e-01 4.71e-01
Viral mRNA Translation 84 1.65e-01 2.48e-01 0.11500 -0.008520 -0.115000 8.93e-01 6.88e-02
Peroxisomal protein import 60 3.30e-01 4.20e-01 0.11500 -0.111000 -0.030700 1.37e-01 6.81e-01
Disorders of transmembrane transporters 166 8.89e-02 1.56e-01 0.11500 -0.083100 -0.079500 6.48e-02 7.73e-02
Peptide chain elongation 84 1.69e-01 2.51e-01 0.11400 -0.007340 -0.114000 9.07e-01 7.12e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 7.45e-01 7.82e-01 0.11400 -0.108000 -0.037600 4.42e-01 7.88e-01
Biosynthesis of specialized proresolving mediators (SPMs) 18 6.17e-01 6.79e-01 0.11400 0.108000 -0.036200 4.28e-01 7.91e-01
Gastrin-CREB signalling pathway via PKC and MAPK 17 7.39e-01 7.78e-01 0.11400 -0.109000 -0.032700 4.37e-01 8.15e-01
rRNA processing 180 6.01e-02 1.18e-01 0.11300 -0.051500 -0.101000 2.33e-01 1.94e-02
Metabolism 1877 5.00e-11 2.11e-09 0.11200 -0.078100 -0.080200 2.37e-08 9.94e-09
Synthesis of PIPs at the Golgi membrane 16 6.31e-01 6.88e-01 0.11200 -0.082300 0.075500 5.68e-01 6.01e-01
Acyl chain remodelling of PE 24 5.05e-01 5.84e-01 0.11100 -0.085400 0.071500 4.69e-01 5.44e-01
Post-chaperonin tubulin folding pathway 21 5.55e-01 6.27e-01 0.11100 0.091700 -0.062900 4.67e-01 6.18e-01
Cargo concentration in the ER 31 6.23e-01 6.81e-01 0.11100 -0.099800 -0.048900 3.36e-01 6.38e-01
Synthesis of PA 35 4.16e-01 5.05e-01 0.11100 -0.107000 0.031400 2.75e-01 7.48e-01
Signaling by NODAL 22 7.39e-01 7.78e-01 0.11100 -0.085300 -0.070600 4.89e-01 5.66e-01
rRNA processing in the nucleus and cytosol 176 7.98e-02 1.44e-01 0.11000 -0.052800 -0.096200 2.27e-01 2.78e-02
Platelet degranulation 114 9.71e-02 1.67e-01 0.11000 0.110000 -0.000322 4.33e-02 9.95e-01
Translation of Structural Proteins 29 6.70e-01 7.19e-01 0.10900 -0.090900 -0.060600 3.97e-01 5.72e-01
Selenoamino acid metabolism 103 9.37e-02 1.62e-01 0.10900 0.021500 -0.107000 7.06e-01 6.08e-02
O-linked glycosylation of mucins 56 3.40e-01 4.31e-01 0.10900 0.109000 0.007570 1.59e-01 9.22e-01
FGFR2 ligand binding and activation 18 7.64e-01 7.98e-01 0.10900 -0.099400 -0.043600 4.65e-01 7.49e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 6.80e-01 7.27e-01 0.10900 0.031700 -0.104000 8.26e-01 4.72e-01
Selenocysteine synthesis 87 1.76e-01 2.60e-01 0.10800 -0.000376 -0.108000 9.95e-01 8.03e-02
ABC transporter disorders 75 2.40e-01 3.28e-01 0.10800 -0.007380 -0.108000 9.12e-01 1.06e-01
Abacavir ADME 10 8.69e-01 8.93e-01 0.10800 -0.053100 -0.094300 7.71e-01 6.06e-01
Synthesis of PIPs at the early endosome membrane 14 7.92e-01 8.22e-01 0.10800 -0.026400 -0.105000 8.64e-01 4.97e-01
Gluconeogenesis 32 6.38e-01 6.94e-01 0.10800 -0.050000 -0.095300 6.25e-01 3.51e-01
Interleukin-6 family signaling 24 6.28e-01 6.85e-01 0.10800 -0.002690 -0.108000 9.82e-01 3.62e-01
Regulation of IFNA/IFNB signaling 16 6.56e-01 7.09e-01 0.10700 0.085400 -0.065100 5.54e-01 6.52e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 27 5.28e-01 6.03e-01 0.10700 -0.102000 0.033500 3.60e-01 7.63e-01
Fatty acid metabolism 158 7.42e-02 1.35e-01 0.10700 -0.023500 -0.104000 6.11e-01 2.38e-02
ATF6 (ATF6-alpha) activates chaperones 11 7.55e-01 7.91e-01 0.10500 0.071300 -0.077400 6.82e-01 6.57e-01
Response to elevated platelet cytosolic Ca2+ 119 8.76e-02 1.55e-01 0.10500 0.104000 -0.013700 4.97e-02 7.96e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 20 7.83e-01 8.13e-01 0.10400 -0.064800 -0.081800 6.16e-01 5.27e-01
Sema4D induced cell migration and growth-cone collapse 20 7.52e-01 7.89e-01 0.10400 -0.036800 -0.097500 7.76e-01 4.50e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 6.22e-01 6.80e-01 0.10200 -0.067800 -0.076200 4.52e-01 3.99e-01
Signaling by RAS mutants 41 6.22e-01 6.80e-01 0.10200 -0.067800 -0.076200 4.52e-01 3.99e-01
Signaling by moderate kinase activity BRAF mutants 41 6.22e-01 6.80e-01 0.10200 -0.067800 -0.076200 4.52e-01 3.99e-01
Signaling downstream of RAS mutants 41 6.22e-01 6.80e-01 0.10200 -0.067800 -0.076200 4.52e-01 3.99e-01
ROS and RNS production in phagocytes 34 4.43e-01 5.30e-01 0.10200 -0.074200 0.069900 4.54e-01 4.81e-01
Visual phototransduction 91 3.52e-01 4.43e-01 0.10200 0.076700 0.066500 2.06e-01 2.73e-01
Regulation of TP53 Activity through Methylation 16 6.99e-01 7.42e-01 0.10100 -0.043700 0.091500 7.62e-01 5.26e-01
G alpha (s) signalling events 150 9.30e-02 1.61e-01 0.10100 -0.100000 -0.012200 3.42e-02 7.96e-01
Leishmania infection 242 4.48e-02 9.42e-02 0.10100 -0.092700 -0.039600 1.30e-02 2.88e-01
TCR signaling 111 7.58e-02 1.38e-01 0.10100 0.067900 -0.074300 2.17e-01 1.76e-01
Activation of the phototransduction cascade 11 8.81e-01 9.03e-01 0.10000 0.081800 0.058300 6.38e-01 7.38e-01
Plasma lipoprotein remodeling 31 4.99e-01 5.79e-01 0.10000 -0.051500 0.085800 6.19e-01 4.08e-01
Diseases associated with the TLR signaling cascade 29 6.57e-01 7.09e-01 0.09730 0.014500 0.096200 8.92e-01 3.70e-01
Diseases of Immune System 29 6.57e-01 7.09e-01 0.09730 0.014500 0.096200 8.92e-01 3.70e-01
Hyaluronan metabolism 15 8.17e-01 8.44e-01 0.09730 -0.094400 -0.023700 5.27e-01 8.74e-01
Signaling by RAF1 mutants 37 6.77e-01 7.24e-01 0.09650 -0.077200 -0.057800 4.16e-01 5.43e-01
Metabolism of water-soluble vitamins and cofactors 111 2.88e-01 3.74e-01 0.09640 -0.044900 -0.085300 4.14e-01 1.21e-01
Interleukin-2 family signaling 39 4.57e-01 5.40e-01 0.09570 0.085300 -0.043300 3.56e-01 6.40e-01
SHC1 events in EGFR signaling 13 8.76e-01 9.00e-01 0.09510 0.060800 0.073200 7.04e-01 6.48e-01
Degradation of the extracellular matrix 101 3.69e-01 4.59e-01 0.09450 -0.065900 -0.067800 2.53e-01 2.39e-01
Synthesis of bile acids and bile salts 34 6.33e-01 6.90e-01 0.09390 0.092700 0.014500 3.49e-01 8.84e-01
Metabolism of vitamins and cofactors 173 1.81e-01 2.64e-01 0.09340 -0.054300 -0.076000 2.18e-01 8.48e-02
O-linked glycosylation 96 2.28e-01 3.15e-01 0.09190 0.009290 -0.091500 8.75e-01 1.22e-01
NOD1/2 Signaling Pathway 27 6.80e-01 7.27e-01 0.09180 -0.091800 -0.001030 4.09e-01 9.93e-01
Cellular hexose transport 19 8.05e-01 8.34e-01 0.09150 0.028000 0.087100 8.33e-01 5.11e-01
p130Cas linkage to MAPK signaling for integrins 15 7.54e-01 7.90e-01 0.09130 0.075800 -0.050900 6.11e-01 7.33e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 28 6.61e-01 7.12e-01 0.09030 0.008020 -0.089900 9.41e-01 4.10e-01
Acyl chain remodelling of PI 16 8.12e-01 8.40e-01 0.09010 0.008110 0.089700 9.55e-01 5.34e-01
Reproduction 75 2.68e-01 3.58e-01 0.08970 0.080300 -0.040200 2.29e-01 5.48e-01
Thromboxane signalling through TP receptor 24 7.78e-01 8.10e-01 0.08940 -0.031700 -0.083600 7.88e-01 4.78e-01
Sema3A PAK dependent Axon repulsion 14 8.18e-01 8.45e-01 0.08620 0.016600 -0.084500 9.14e-01 5.84e-01
Pre-NOTCH Expression and Processing 55 5.29e-01 6.04e-01 0.08550 -0.085100 -0.008820 2.75e-01 9.10e-01
Advanced glycosylation endproduct receptor signaling 13 8.89e-01 9.10e-01 0.08500 0.077300 0.035300 6.29e-01 8.25e-01
Azathioprine ADME 22 7.47e-01 7.84e-01 0.08470 0.009970 -0.084200 9.35e-01 4.94e-01
Thrombin signalling through proteinase activated receptors (PARs) 32 6.13e-01 6.75e-01 0.08440 -0.077400 0.033900 4.49e-01 7.40e-01
Plasma lipoprotein assembly, remodeling, and clearance 71 5.32e-01 6.05e-01 0.08370 -0.076800 -0.033300 2.63e-01 6.28e-01
Signaling by Interleukins 411 4.25e-02 9.06e-02 0.08160 -0.042500 -0.069700 1.39e-01 1.55e-02
Platelet Adhesion to exposed collagen 13 8.56e-01 8.82e-01 0.08140 -0.006310 0.081200 9.69e-01 6.12e-01
Peroxisomal lipid metabolism 27 6.82e-01 7.28e-01 0.08110 0.032900 -0.074200 7.67e-01 5.05e-01
rRNA modification in the nucleus and cytosol 51 5.87e-01 6.54e-01 0.08060 -0.080300 -0.006610 3.21e-01 9.35e-01
SARS-CoV-2 modulates host translation machinery 45 6.19e-01 6.80e-01 0.08050 -0.003860 -0.080400 9.64e-01 3.51e-01
Glucagon-type ligand receptors 32 7.14e-01 7.55e-01 0.08000 -0.079900 -0.004150 4.34e-01 9.68e-01
Attenuation phase 25 8.09e-01 8.37e-01 0.07890 0.023600 0.075300 8.38e-01 5.15e-01
Signaling by high-kinase activity BRAF mutants 32 7.23e-01 7.63e-01 0.07860 -0.078500 -0.004240 4.42e-01 9.67e-01
MAP2K and MAPK activation 33 7.42e-01 7.80e-01 0.07740 -0.076300 -0.013100 4.48e-01 8.96e-01
HSF1-dependent transactivation 35 7.91e-01 8.21e-01 0.07510 -0.065100 -0.037500 5.05e-01 7.01e-01
ADORA2B mediated anti-inflammatory cytokines production 130 2.02e-01 2.85e-01 0.07430 -0.063400 0.038800 2.12e-01 4.45e-01
Cell-cell junction organization 56 7.12e-01 7.53e-01 0.07410 -0.052300 -0.052400 4.98e-01 4.97e-01
Post-translational protein phosphorylation 95 4.02e-01 4.93e-01 0.07350 0.004640 -0.073300 9.38e-01 2.17e-01
GPVI-mediated activation cascade 32 7.56e-01 7.91e-01 0.07320 -0.004400 -0.073000 9.66e-01 4.75e-01
Vitamin B5 (pantothenate) metabolism 16 9.09e-01 9.28e-01 0.07310 -0.051400 -0.052000 7.22e-01 7.19e-01
Processive synthesis on the lagging strand 14 8.67e-01 8.92e-01 0.07260 0.014000 -0.071200 9.28e-01 6.45e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 9.03e-01 9.23e-01 0.07230 0.014900 -0.070800 9.35e-01 6.98e-01
Anti-inflammatory response favouring Leishmania parasite infection 162 2.53e-01 3.40e-01 0.07100 -0.071000 -0.000585 1.19e-01 9.90e-01
Leishmania parasite growth and survival 162 2.53e-01 3.40e-01 0.07100 -0.071000 -0.000585 1.19e-01 9.90e-01
Metabolism of amino acids and derivatives 337 8.89e-02 1.56e-01 0.07020 -0.013600 -0.068900 6.67e-01 2.99e-02
FCGR activation 12 9.29e-01 9.44e-01 0.06950 0.027600 0.063800 8.68e-01 7.02e-01
Amyloid fiber formation 53 5.83e-01 6.51e-01 0.06730 -0.056700 0.036400 4.75e-01 6.47e-01
Metabolism of steroids 143 4.57e-01 5.40e-01 0.06720 -0.059700 -0.030900 2.18e-01 5.23e-01
Interferon Signaling 183 1.66e-01 2.49e-01 0.06660 0.033300 -0.057700 4.37e-01 1.79e-01
Diseases of carbohydrate metabolism 29 7.54e-01 7.90e-01 0.06650 -0.059000 0.030800 5.83e-01 7.74e-01
Hemostasis 544 4.34e-02 9.19e-02 0.06630 -0.021200 -0.062900 3.99e-01 1.23e-02
CD209 (DC-SIGN) signaling 20 8.39e-01 8.65e-01 0.06580 0.018500 -0.063100 8.86e-01 6.25e-01
Serotonin receptors 11 9.30e-01 9.44e-01 0.06510 0.007750 0.064600 9.65e-01 7.11e-01
Free fatty acids regulate insulin secretion 10 9.10e-01 9.28e-01 0.06490 -0.034300 0.055100 8.51e-01 7.63e-01
Antigen processing-Cross presentation 100 5.24e-01 6.00e-01 0.06450 -0.008250 -0.064000 8.87e-01 2.69e-01
Interleukin-4 and Interleukin-13 signaling 102 6.42e-01 6.99e-01 0.06270 -0.043900 -0.044700 4.43e-01 4.36e-01
Interleukin-12 signaling 43 7.09e-01 7.51e-01 0.06170 0.057700 -0.021700 5.12e-01 8.06e-01
Processing of SMDT1 10 9.16e-01 9.34e-01 0.06160 0.046100 -0.040900 8.01e-01 8.23e-01
Adaptive Immune System 692 4.43e-02 9.35e-02 0.06090 -0.025300 -0.055400 2.57e-01 1.31e-02
Platelet activation, signaling and aggregation 242 2.36e-01 3.24e-01 0.05970 -0.000722 -0.059700 9.85e-01 1.10e-01
Nicotinamide salvaging 16 9.21e-01 9.38e-01 0.05870 0.057700 0.011200 6.90e-01 9.38e-01
Neutrophil degranulation 442 3.48e-02 7.83e-02 0.05850 -0.048200 0.033200 8.25e-02 2.32e-01
Cytokine Signaling in Immune system 640 5.41e-02 1.09e-01 0.05780 -0.014900 -0.055800 5.21e-01 1.61e-02
G-protein activation 24 9.02e-01 9.23e-01 0.05710 -0.053600 -0.019600 6.49e-01 8.68e-01
TNFR2 non-canonical NF-kB pathway 93 6.98e-01 7.41e-01 0.05580 -0.023900 -0.050500 6.91e-01 4.00e-01
Metalloprotease DUBs 18 9.26e-01 9.42e-01 0.05460 -0.053000 -0.013300 6.97e-01 9.22e-01
GAB1 signalosome 16 9.41e-01 9.53e-01 0.05420 -0.050000 -0.020900 7.29e-01 8.85e-01
Pyrimidine catabolism 11 9.51e-01 9.60e-01 0.05230 0.052300 0.001420 7.64e-01 9.93e-01
G alpha (i) signalling events 285 4.34e-01 5.22e-01 0.05160 0.038800 0.034000 2.60e-01 3.23e-01
RHO GTPases activate KTN1 11 9.67e-01 9.72e-01 0.04970 -0.022500 -0.044300 8.97e-01 7.99e-01
Amine ligand-binding receptors 41 8.66e-01 8.91e-01 0.04770 0.006730 0.047200 9.41e-01 6.01e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 112 7.09e-01 7.51e-01 0.04500 0.044500 0.007240 4.16e-01 8.95e-01
RA biosynthesis pathway 21 9.25e-01 9.41e-01 0.04450 -0.006620 0.044000 9.58e-01 7.27e-01
Tie2 Signaling 18 9.52e-01 9.61e-01 0.04440 -0.012900 -0.042500 9.24e-01 7.55e-01
Class I peroxisomal membrane protein import 18 9.56e-01 9.64e-01 0.04330 -0.014300 -0.040900 9.17e-01 7.64e-01
Biosynthesis of DHA-derived SPMs 16 9.34e-01 9.47e-01 0.04290 0.028400 -0.032200 8.44e-01 8.24e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 39 9.06e-01 9.25e-01 0.04210 0.040900 0.009850 6.58e-01 9.15e-01
Metabolism of porphyrins 27 9.05e-01 9.25e-01 0.04200 -0.014300 0.039500 8.97e-01 7.22e-01
HSF1 activation 27 9.35e-01 9.47e-01 0.04040 0.005730 0.040000 9.59e-01 7.19e-01
Interleukin-12 family signaling 53 8.56e-01 8.82e-01 0.03870 0.008580 -0.037700 9.14e-01 6.35e-01
Innate Immune System 946 7.83e-02 1.42e-01 0.03840 -0.006680 0.037800 7.28e-01 4.92e-02
Post-translational modification: synthesis of GPI-anchored proteins 84 7.75e-01 8.08e-01 0.03780 -0.035000 0.014400 5.80e-01 8.19e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 14 9.71e-01 9.75e-01 0.03770 0.036900 0.007530 8.11e-01 9.61e-01
C-type lectin receptors (CLRs) 131 7.99e-01 8.28e-01 0.03750 -0.033500 -0.016900 5.08e-01 7.39e-01
Peptide hormone metabolism 78 8.82e-01 9.04e-01 0.03680 -0.018200 -0.032000 7.81e-01 6.25e-01
Platelet Aggregation (Plug Formation) 37 9.45e-01 9.55e-01 0.03680 -0.022600 -0.029000 8.12e-01 7.60e-01
Pre-NOTCH Transcription and Translation 40 9.02e-01 9.23e-01 0.03450 -0.031100 0.014800 7.33e-01 8.71e-01
RAS processing 16 9.77e-01 9.79e-01 0.03420 -0.014500 -0.031000 9.20e-01 8.30e-01
Detoxification of Reactive Oxygen Species 34 9.57e-01 9.64e-01 0.03400 -0.024100 -0.024100 8.08e-01 8.08e-01
Nucleotide salvage 21 9.63e-01 9.69e-01 0.03120 0.003930 -0.030900 9.75e-01 8.06e-01
Carboxyterminal post-translational modifications of tubulin 35 9.67e-01 9.72e-01 0.02690 0.009220 0.025300 9.25e-01 7.96e-01
Retinoid metabolism and transport 41 9.55e-01 9.63e-01 0.02430 -0.023900 0.004520 7.91e-01 9.60e-01
MHC class II antigen presentation 102 9.32e-01 9.46e-01 0.02350 -0.009800 -0.021400 8.64e-01 7.09e-01
Gap junction trafficking and regulation 29 9.83e-01 9.84e-01 0.02330 -0.015700 -0.017300 8.84e-01 8.72e-01
Signaling by GPCR 629 5.82e-01 6.50e-01 0.02280 -0.022800 0.000102 3.30e-01 9.97e-01
Metabolism of fat-soluble vitamins 45 9.67e-01 9.72e-01 0.02170 -0.021500 -0.002270 8.03e-01 9.79e-01
Gap junction trafficking 27 9.76e-01 9.79e-01 0.02010 0.017200 -0.010500 8.77e-01 9.25e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 35 9.78e-01 9.80e-01 0.01800 0.003980 -0.017600 9.67e-01 8.57e-01
NR1H2 and NR1H3-mediated signaling 48 9.86e-01 9.87e-01 0.01580 0.013200 0.008680 8.74e-01 9.17e-01
G alpha (q) signalling events 196 9.42e-01 9.53e-01 0.01180 -0.006020 0.010100 8.85e-01 8.07e-01
GPCR downstream signalling 570 8.78e-01 9.01e-01 0.01010 -0.006230 0.007970 8.00e-01 7.45e-01
Immune System 1791 9.42e-01 9.53e-01 0.00574 0.004190 0.003920 7.69e-01 7.84e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 20 9.99e-01 9.99e-01 0.00548 0.000120 -0.005480 9.99e-01 9.66e-01


Detailed Gene set reports


Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors
metric value
setSize 308
pMANOVA 7.69e-120
p.adjustMANOVA 1.17e-116
s.dist 0.895
s.estill 0.666
s.novakovic 0.597
p.estill 9.86e-91
p.novakovic 4.26e-73




Top 20 genes
Gene estill novakovic
OR1I1 2621.0 2132.0
OR9Q2 2109.0 2023.0
OR7D2 1960.0 2132.0
OR2AG2 2324.0 1794.5
OR11H4 1960.0 1585.5
OR4E2 1960.0 1585.5
OR52I2 2621.0 1142.5
OR1B1 1960.0 1505.0
OR10T2 1960.0 1419.0
OR1E1 1960.0 1419.0
OR2A5 1960.0 1419.0
OR2J3 1575.0 1700.0
OR10G2 2621.0 1001.5
OR10G8 3196.0 713.5
OR6V1 964.5 2013.0
OR6B3 1575.0 1001.5
OR7C1 854.0 1834.5
OR5A2 854.0 1794.5
OR7C2 1575.0 967.0
OR9Q1 764.5 1871.5

Click HERE to show all gene set members

All member genes
estill novakovic
EBF1 -4078.5 -17427.5
LDB1 -12956.5 -15770.0
LHX2 -10604.5 -6638.5
OR10A2 -2059.5 1419.0
OR10A3 2986.0 -9711.0
OR10A4 0.5 -1230.0
OR10A5 -5708.5 -3457.5
OR10A6 0.5 -3457.5
OR10AD1 1575.0 -1405.5
OR10C1 1136.0 -5365.0
OR10G2 2621.0 1001.5
OR10G3 0.5 1142.5
OR10G4 1254.0 -8277.5
OR10G7 -2059.5 -589.0
OR10G8 3196.0 713.5
OR10G9 1960.0 -686.0
OR10H1 2873.5 -446.0
OR10H2 -1680.5 -996.5
OR10H3 0.5 0.5
OR10H4 0.5 -1230.0
OR10H5 -2059.5 -1955.5
OR10J1 2986.0 0.5
OR10J3 2621.0 0.5
OR10J5 964.5 0.5
OR10K1 0.5 1419.0
OR10K2 -2824.0 -2900.0
OR10P1 -2824.0 -2900.0
OR10Q1 688.0 1771.0
OR10S1 0.5 -3457.5
OR10T2 1960.0 1419.0
OR10V1 2621.0 -3457.5
OR10W1 1960.0 -8277.5
OR10X1 1960.0 -3457.5
OR10Z1 -2059.5 -2900.0
OR11A1 2799.5 0.5
OR11G2 0.5 -6828.5
OR11H4 1960.0 1585.5
OR11H6 0.5 1923.5
OR11L1 3134.5 -5571.0
OR12D2 -2506.0 900.5
OR12D3 656.0 -3992.0
OR13A1 2986.0 -14160.0
OR13C3 0.5 -4250.0
OR13C4 0.5 -1746.0
OR13C8 0.5 0.5
OR13F1 0.5 -3457.5
OR13J1 -2059.5 -996.5
OR14A16 -2824.0 -6326.0
OR14C36 0.5 -1230.0
OR14I1 0.5 0.5
OR14J1 2519.0 -743.0
OR1A1 2986.0 -5925.0
OR1A2 -1082.0 -2137.0
OR1B1 1960.0 1505.0
OR1C1 -3883.0 -4814.5
OR1D2 0.5 0.5
OR1D4 0.5 0.5
OR1D5 0.5 0.5
OR1E1 1960.0 1419.0
OR1E2 -2824.0 -885.5
OR1F1 -5708.5 0.5
OR1G1 3196.0 -686.0
OR1I1 2621.0 2132.0
OR1J1 -2059.5 -6828.5
OR1J2 0.5 -3457.5
OR1J4 0.5 1923.5
OR1K1 1960.0 -2137.0
OR1L3 0.5 -506.5
OR1L6 0.5 0.5
OR1M1 0.5 -3028.0
OR1N1 0.5 0.5
OR1Q1 0.5 0.5
OR1S1 -2059.5 -2500.5
OR1S2 0.5 0.5
OR2A12 1960.0 -2500.5
OR2A14 0.5 0.5
OR2A2 0.5 0.5
OR2A25 0.5 0.5
OR2A4 0.5 0.5
OR2A5 1960.0 1419.0
OR2AE1 0.5 0.5
OR2AG1 0.5 2319.0
OR2AG2 2324.0 1794.5
OR2AT4 1960.0 0.5
OR2B11 2718.5 -2704.0
OR2B2 0.5 1288.5
OR2B3 854.0 -996.5
OR2C1 -1509.0 2319.0
OR2C3 2833.0 -6427.5
OR2D2 0.5 1923.5
OR2D3 0.5 -3457.5
OR2F1 0.5 -8277.5
OR2F2 0.5 -1746.0
OR2G2 1960.0 -1230.0
OR2G3 0.5 -818.0
OR2G6 1960.0 -2900.0
OR2H1 3422.5 -11119.5
OR2H2 3233.5 -8566.5
OR2J2 -2824.0 -1230.0
OR2J3 1575.0 1700.0
OR2K2 0.5 -818.0
OR2L13 2914.5 -4562.5
OR2L2 0.5 852.5
OR2L3 -2059.5 0.5
OR2L8 0.5 -860.0
OR2M2 1960.0 -996.5
OR2M3 -2059.5 0.5
OR2M4 0.5 -5237.0
OR2M5 -1082.0 -1405.5
OR2M7 0.5 -1746.0
OR2S2 0.5 0.5
OR2T1 0.5 -8277.5
OR2T11 0.5 -3457.5
OR2T12 1960.0 -1746.0
OR2T27 1960.0 -1746.0
OR2T29 0.5 852.5
OR2T3 1960.0 -2137.0
OR2T33 -2824.0 1585.5
OR2T34 0.5 -2900.0
OR2T4 0.5 1700.0
OR2T5 0.5 1142.5
OR2T6 0.5 -5237.0
OR2T8 0.5 -8277.5
OR2V2 2442.0 -3028.0
OR2W3 0.5 -1746.0
OR2W5 1960.0 -5571.0
OR2Y1 1575.0 -506.5
OR2Z1 -1082.0 2270.0
OR3A1 2621.0 -2500.5
OR3A2 -837.5 -6326.0
OR3A3 1960.0 0.5
OR4A15 0.5 2167.0
OR4A47 0.5 1419.0
OR4A5 0.5 0.5
OR4B1 0.5 -2137.0
OR4C13 0.5 0.5
OR4C15 0.5 1419.0
OR4C16 -2059.5 1923.5
OR4C45 0.5 0.5
OR4C6 0.5 1419.0
OR4D1 3196.0 -6326.0
OR4D10 0.5 -506.5
OR4D11 0.5 -2500.5
OR4D2 1084.0 -1230.0
OR4D5 0.5 0.5
OR4D6 1960.0 -1230.0
OR4D9 0.5 -506.5
OR4E2 1960.0 1585.5
OR4F15 0.5 -6828.5
OR4F5 0.5 0.5
OR4F6 1960.0 -506.5
OR4K1 -3883.0 -506.5
OR4K13 0.5 1419.0
OR4K14 0.5 0.5
OR4K15 0.5 0.5
OR4K17 0.5 -8277.5
OR4K2 0.5 -4250.0
OR4N2 -2059.5 1923.5
OR4N5 -3883.0 1142.5
OR4Q3 0.5 -818.0
OR4S1 0.5 1142.5
OR4S2 0.5 0.5
OR4X1 -3883.0 0.5
OR51A2 0.5 -6828.5
OR51A7 -1509.0 1585.5
OR51B2 -2059.5 -996.5
OR51B4 0.5 -2900.0
OR51B5 0.5 -13049.0
OR51B6 0.5 0.5
OR51D1 854.0 -4250.0
OR51E1 3196.0 -6631.0
OR51E2 -2059.5 -7199.5
OR51F1 1960.0 0.5
OR51F2 0.5 -2137.0
OR51G1 2986.0 -996.5
OR51G2 0.5 0.5
OR51I1 0.5 -686.0
OR51I2 2986.0 -9711.0
OR51L1 0.5 -4677.5
OR51M1 0.5 -3457.5
OR51Q1 -1509.0 -2900.0
OR51S1 1254.0 -506.5
OR51T1 -3883.0 1142.5
OR51V1 0.5 -1746.0
OR52A1 0.5 -1746.0
OR52B2 2442.0 -5925.0
OR52B6 3196.0 -1955.5
OR52D1 0.5 -1746.0
OR52E2 -2059.5 0.5
OR52E4 0.5 0.5
OR52E6 0.5 1419.0
OR52H1 -2059.5 -1746.0
OR52I1 -2059.5 -3457.5
OR52I2 2621.0 1142.5
OR52J3 1960.0 0.5
OR52K1 0.5 -1746.0
OR52K2 0.5 -1230.0
OR52L1 -2059.5 -818.0
OR52M1 2621.0 -5237.0
OR52N1 0.5 -3457.5
OR52N2 0.5 0.5
OR52N5 0.5 0.5
OR52R1 1960.0 -3457.5
OR52W1 2183.5 -10989.5
OR56A1 0.5 0.5
OR56A3 0.5 0.5
OR56A4 854.0 1142.5
OR56B1 0.5 -1746.0
OR56B4 0.5 1419.0
OR5A1 854.0 -996.5
OR5A2 854.0 1794.5
OR5AK2 0.5 0.5
OR5AN1 0.5 0.5
OR5AP2 0.5 -3457.5
OR5AR1 0.5 0.5
OR5AS1 0.5 1001.5
OR5AU1 2442.0 -2900.0
OR5B12 0.5 -3805.5
OR5B17 0.5 -1746.0
OR5B2 0.5 1419.0
OR5B21 -3883.0 -3457.5
OR5B3 0.5 0.5
OR5C1 1960.0 0.5
OR5D13 0.5 0.5
OR5D14 -2059.5 -1746.0
OR5D16 0.5 -818.0
OR5D18 0.5 -3805.5
OR5H1 0.5 0.5
OR5I1 -2059.5 -1230.0
OR5K2 0.5 -5237.0
OR5L1 0.5 -818.0
OR5L2 0.5 -818.0
OR5M1 0.5 -5237.0
OR5M10 -1082.0 -996.5
OR5M11 0.5 0.5
OR5M8 2621.0 0.5
OR5M9 0.5 -3457.5
OR5P2 0.5 1923.5
OR5P3 0.5 0.5
OR5R1 0.5 -1746.0
OR5T2 0.5 0.5
OR5V1 -7328.5 -2500.5
OR6A2 -2059.5 -506.5
OR6B1 0.5 -3028.0
OR6B2 -5101.0 2190.5
OR6B3 1575.0 1001.5
OR6C1 0.5 0.5
OR6C3 0.5 1419.0
OR6C4 0.5 -1746.0
OR6C70 0.5 -3457.5
OR6C74 0.5 -5237.0
OR6F1 -3883.0 -2900.0
OR6K2 0.5 -5571.0
OR6K3 0.5 1794.5
OR6K6 2621.0 -1129.0
OR6M1 2621.0 -2137.0
OR6N1 1960.0 0.5
OR6N2 0.5 541.0
OR6P1 0.5 -3805.5
OR6Q1 0.5 0.5
OR6S1 854.0 -1230.0
OR6T1 1960.0 -2137.0
OR6V1 964.5 2013.0
OR6X1 1960.0 -8277.5
OR6Y1 1960.0 -1746.0
OR7A10 0.5 1419.0
OR7A17 1084.0 -374.0
OR7A5 2986.0 -4677.5
OR7C1 854.0 1834.5
OR7C2 1575.0 967.0
OR7D2 1960.0 2132.0
OR7D4 -1509.0 1142.5
OR7E24 0.5 1923.5
OR7G1 0.5 2039.5
OR7G2 -2059.5 0.5
OR7G3 0.5 0.5
OR8A1 0.5 -2137.0
OR8B12 -2824.0 -2500.5
OR8B2 0.5 -3457.5
OR8B3 0.5 0.5
OR8B4 2621.0 -4814.5
OR8B8 0.5 1314.0
OR8D1 2621.0 -3457.5
OR8D2 0.5 -3457.5
OR8D4 1254.0 -2900.0
OR8G1 1254.0 -8884.5
OR8G2 0.5 0.5
OR8G5 0.5 -5237.0
OR8H1 0.5 0.5
OR8H2 -3883.0 1700.0
OR8H3 -5708.5 541.0
OR8I2 0.5 0.5
OR8J3 0.5 -3457.5
OR8K5 0.5 -818.0
OR8S1 -1264.0 -3976.0
OR8U8 -2884.0 -3837.5
OR9A2 -2059.5 713.5
OR9A4 2621.0 -2500.5
OR9G1 0.5 -2500.5
OR9G4 0.5 -2500.5
OR9G9 0.5 -2500.5
OR9I1 0.5 1419.0
OR9K2 0.5 -3457.5
OR9Q1 764.5 1871.5
OR9Q2 2109.0 2023.0
REEP1 -8460.0 -17415.5
RTP1 0.5 0.5
RTP2 -1398.5 -1842.0



Olfactory Signaling Pathway

Olfactory Signaling Pathway
metric value
setSize 315
pMANOVA 1.67e-114
p.adjustMANOVA 1.27e-111
s.dist 0.865
s.estill 0.646
s.novakovic 0.575
p.estill 2.95e-87
p.novakovic 2.28e-69




Top 20 genes
Gene estill novakovic
OR1I1 2621.0 2132.0
OR9Q2 2109.0 2023.0
OR7D2 1960.0 2132.0
OR2AG2 2324.0 1794.5
OR11H4 1960.0 1585.5
OR4E2 1960.0 1585.5
OR52I2 2621.0 1142.5
OR1B1 1960.0 1505.0
OR10T2 1960.0 1419.0
OR1E1 1960.0 1419.0
OR2A5 1960.0 1419.0
OR2J3 1575.0 1700.0
OR10G2 2621.0 1001.5
OR10G8 3196.0 713.5
OR6V1 964.5 2013.0
OR6B3 1575.0 1001.5
OR7C1 854.0 1834.5
OR5A2 854.0 1794.5
OR7C2 1575.0 967.0
OR9Q1 764.5 1871.5

Click HERE to show all gene set members

All member genes
estill novakovic
ADCY3 -10865.5 -10085.5
ANO2 -4232.5 -12274.5
CNGA4 -4974.0 -8805.5
CNGB1 -15190.5 -14797.5
EBF1 -4078.5 -17427.5
GNAL -15815.5 -17412.5
GNB1 -6248.5 -9375.5
GNG13 -5561.5 -8336.0
LDB1 -12956.5 -15770.0
LHX2 -10604.5 -6638.5
OR10A2 -2059.5 1419.0
OR10A3 2986.0 -9711.0
OR10A4 0.5 -1230.0
OR10A5 -5708.5 -3457.5
OR10A6 0.5 -3457.5
OR10AD1 1575.0 -1405.5
OR10C1 1136.0 -5365.0
OR10G2 2621.0 1001.5
OR10G3 0.5 1142.5
OR10G4 1254.0 -8277.5
OR10G7 -2059.5 -589.0
OR10G8 3196.0 713.5
OR10G9 1960.0 -686.0
OR10H1 2873.5 -446.0
OR10H2 -1680.5 -996.5
OR10H3 0.5 0.5
OR10H4 0.5 -1230.0
OR10H5 -2059.5 -1955.5
OR10J1 2986.0 0.5
OR10J3 2621.0 0.5
OR10J5 964.5 0.5
OR10K1 0.5 1419.0
OR10K2 -2824.0 -2900.0
OR10P1 -2824.0 -2900.0
OR10Q1 688.0 1771.0
OR10S1 0.5 -3457.5
OR10T2 1960.0 1419.0
OR10V1 2621.0 -3457.5
OR10W1 1960.0 -8277.5
OR10X1 1960.0 -3457.5
OR10Z1 -2059.5 -2900.0
OR11A1 2799.5 0.5
OR11G2 0.5 -6828.5
OR11H4 1960.0 1585.5
OR11H6 0.5 1923.5
OR11L1 3134.5 -5571.0
OR12D2 -2506.0 900.5
OR12D3 656.0 -3992.0
OR13A1 2986.0 -14160.0
OR13C3 0.5 -4250.0
OR13C4 0.5 -1746.0
OR13C8 0.5 0.5
OR13F1 0.5 -3457.5
OR13J1 -2059.5 -996.5
OR14A16 -2824.0 -6326.0
OR14C36 0.5 -1230.0
OR14I1 0.5 0.5
OR14J1 2519.0 -743.0
OR1A1 2986.0 -5925.0
OR1A2 -1082.0 -2137.0
OR1B1 1960.0 1505.0
OR1C1 -3883.0 -4814.5
OR1D2 0.5 0.5
OR1D4 0.5 0.5
OR1D5 0.5 0.5
OR1E1 1960.0 1419.0
OR1E2 -2824.0 -885.5
OR1F1 -5708.5 0.5
OR1G1 3196.0 -686.0
OR1I1 2621.0 2132.0
OR1J1 -2059.5 -6828.5
OR1J2 0.5 -3457.5
OR1J4 0.5 1923.5
OR1K1 1960.0 -2137.0
OR1L3 0.5 -506.5
OR1L6 0.5 0.5
OR1M1 0.5 -3028.0
OR1N1 0.5 0.5
OR1Q1 0.5 0.5
OR1S1 -2059.5 -2500.5
OR1S2 0.5 0.5
OR2A12 1960.0 -2500.5
OR2A14 0.5 0.5
OR2A2 0.5 0.5
OR2A25 0.5 0.5
OR2A4 0.5 0.5
OR2A5 1960.0 1419.0
OR2AE1 0.5 0.5
OR2AG1 0.5 2319.0
OR2AG2 2324.0 1794.5
OR2AT4 1960.0 0.5
OR2B11 2718.5 -2704.0
OR2B2 0.5 1288.5
OR2B3 854.0 -996.5
OR2C1 -1509.0 2319.0
OR2C3 2833.0 -6427.5
OR2D2 0.5 1923.5
OR2D3 0.5 -3457.5
OR2F1 0.5 -8277.5
OR2F2 0.5 -1746.0
OR2G2 1960.0 -1230.0
OR2G3 0.5 -818.0
OR2G6 1960.0 -2900.0
OR2H1 3422.5 -11119.5
OR2H2 3233.5 -8566.5
OR2J2 -2824.0 -1230.0
OR2J3 1575.0 1700.0
OR2K2 0.5 -818.0
OR2L13 2914.5 -4562.5
OR2L2 0.5 852.5
OR2L3 -2059.5 0.5
OR2L8 0.5 -860.0
OR2M2 1960.0 -996.5
OR2M3 -2059.5 0.5
OR2M4 0.5 -5237.0
OR2M5 -1082.0 -1405.5
OR2M7 0.5 -1746.0
OR2S2 0.5 0.5
OR2T1 0.5 -8277.5
OR2T11 0.5 -3457.5
OR2T12 1960.0 -1746.0
OR2T27 1960.0 -1746.0
OR2T29 0.5 852.5
OR2T3 1960.0 -2137.0
OR2T33 -2824.0 1585.5
OR2T34 0.5 -2900.0
OR2T4 0.5 1700.0
OR2T5 0.5 1142.5
OR2T6 0.5 -5237.0
OR2T8 0.5 -8277.5
OR2V2 2442.0 -3028.0
OR2W3 0.5 -1746.0
OR2W5 1960.0 -5571.0
OR2Y1 1575.0 -506.5
OR2Z1 -1082.0 2270.0
OR3A1 2621.0 -2500.5
OR3A2 -837.5 -6326.0
OR3A3 1960.0 0.5
OR4A15 0.5 2167.0
OR4A47 0.5 1419.0
OR4A5 0.5 0.5
OR4B1 0.5 -2137.0
OR4C13 0.5 0.5
OR4C15 0.5 1419.0
OR4C16 -2059.5 1923.5
OR4C45 0.5 0.5
OR4C6 0.5 1419.0
OR4D1 3196.0 -6326.0
OR4D10 0.5 -506.5
OR4D11 0.5 -2500.5
OR4D2 1084.0 -1230.0
OR4D5 0.5 0.5
OR4D6 1960.0 -1230.0
OR4D9 0.5 -506.5
OR4E2 1960.0 1585.5
OR4F15 0.5 -6828.5
OR4F5 0.5 0.5
OR4F6 1960.0 -506.5
OR4K1 -3883.0 -506.5
OR4K13 0.5 1419.0
OR4K14 0.5 0.5
OR4K15 0.5 0.5
OR4K17 0.5 -8277.5
OR4K2 0.5 -4250.0
OR4N2 -2059.5 1923.5
OR4N5 -3883.0 1142.5
OR4Q3 0.5 -818.0
OR4S1 0.5 1142.5
OR4S2 0.5 0.5
OR4X1 -3883.0 0.5
OR51A2 0.5 -6828.5
OR51A7 -1509.0 1585.5
OR51B2 -2059.5 -996.5
OR51B4 0.5 -2900.0
OR51B5 0.5 -13049.0
OR51B6 0.5 0.5
OR51D1 854.0 -4250.0
OR51E1 3196.0 -6631.0
OR51E2 -2059.5 -7199.5
OR51F1 1960.0 0.5
OR51F2 0.5 -2137.0
OR51G1 2986.0 -996.5
OR51G2 0.5 0.5
OR51I1 0.5 -686.0
OR51I2 2986.0 -9711.0
OR51L1 0.5 -4677.5
OR51M1 0.5 -3457.5
OR51Q1 -1509.0 -2900.0
OR51S1 1254.0 -506.5
OR51T1 -3883.0 1142.5
OR51V1 0.5 -1746.0
OR52A1 0.5 -1746.0
OR52B2 2442.0 -5925.0
OR52B6 3196.0 -1955.5
OR52D1 0.5 -1746.0
OR52E2 -2059.5 0.5
OR52E4 0.5 0.5
OR52E6 0.5 1419.0
OR52H1 -2059.5 -1746.0
OR52I1 -2059.5 -3457.5
OR52I2 2621.0 1142.5
OR52J3 1960.0 0.5
OR52K1 0.5 -1746.0
OR52K2 0.5 -1230.0
OR52L1 -2059.5 -818.0
OR52M1 2621.0 -5237.0
OR52N1 0.5 -3457.5
OR52N2 0.5 0.5
OR52N5 0.5 0.5
OR52R1 1960.0 -3457.5
OR52W1 2183.5 -10989.5
OR56A1 0.5 0.5
OR56A3 0.5 0.5
OR56A4 854.0 1142.5
OR56B1 0.5 -1746.0
OR56B4 0.5 1419.0
OR5A1 854.0 -996.5
OR5A2 854.0 1794.5
OR5AK2 0.5 0.5
OR5AN1 0.5 0.5
OR5AP2 0.5 -3457.5
OR5AR1 0.5 0.5
OR5AS1 0.5 1001.5
OR5AU1 2442.0 -2900.0
OR5B12 0.5 -3805.5
OR5B17 0.5 -1746.0
OR5B2 0.5 1419.0
OR5B21 -3883.0 -3457.5
OR5B3 0.5 0.5
OR5C1 1960.0 0.5
OR5D13 0.5 0.5
OR5D14 -2059.5 -1746.0
OR5D16 0.5 -818.0
OR5D18 0.5 -3805.5
OR5H1 0.5 0.5
OR5I1 -2059.5 -1230.0
OR5K2 0.5 -5237.0
OR5L1 0.5 -818.0
OR5L2 0.5 -818.0
OR5M1 0.5 -5237.0
OR5M10 -1082.0 -996.5
OR5M11 0.5 0.5
OR5M8 2621.0 0.5
OR5M9 0.5 -3457.5
OR5P2 0.5 1923.5
OR5P3 0.5 0.5
OR5R1 0.5 -1746.0
OR5T2 0.5 0.5
OR5V1 -7328.5 -2500.5
OR6A2 -2059.5 -506.5
OR6B1 0.5 -3028.0
OR6B2 -5101.0 2190.5
OR6B3 1575.0 1001.5
OR6C1 0.5 0.5
OR6C3 0.5 1419.0
OR6C4 0.5 -1746.0
OR6C70 0.5 -3457.5
OR6C74 0.5 -5237.0
OR6F1 -3883.0 -2900.0
OR6K2 0.5 -5571.0
OR6K3 0.5 1794.5
OR6K6 2621.0 -1129.0
OR6M1 2621.0 -2137.0
OR6N1 1960.0 0.5
OR6N2 0.5 541.0
OR6P1 0.5 -3805.5
OR6Q1 0.5 0.5
OR6S1 854.0 -1230.0
OR6T1 1960.0 -2137.0
OR6V1 964.5 2013.0
OR6X1 1960.0 -8277.5
OR6Y1 1960.0 -1746.0
OR7A10 0.5 1419.0
OR7A17 1084.0 -374.0
OR7A5 2986.0 -4677.5
OR7C1 854.0 1834.5
OR7C2 1575.0 967.0
OR7D2 1960.0 2132.0
OR7D4 -1509.0 1142.5
OR7E24 0.5 1923.5
OR7G1 0.5 2039.5
OR7G2 -2059.5 0.5
OR7G3 0.5 0.5
OR8A1 0.5 -2137.0
OR8B12 -2824.0 -2500.5
OR8B2 0.5 -3457.5
OR8B3 0.5 0.5
OR8B4 2621.0 -4814.5
OR8B8 0.5 1314.0
OR8D1 2621.0 -3457.5
OR8D2 0.5 -3457.5
OR8D4 1254.0 -2900.0
OR8G1 1254.0 -8884.5
OR8G2 0.5 0.5
OR8G5 0.5 -5237.0
OR8H1 0.5 0.5
OR8H2 -3883.0 1700.0
OR8H3 -5708.5 541.0
OR8I2 0.5 0.5
OR8J3 0.5 -3457.5
OR8K5 0.5 -818.0
OR8S1 -1264.0 -3976.0
OR8U8 -2884.0 -3837.5
OR9A2 -2059.5 713.5
OR9A4 2621.0 -2500.5
OR9G1 0.5 -2500.5
OR9G4 0.5 -2500.5
OR9G9 0.5 -2500.5
OR9I1 0.5 1419.0
OR9K2 0.5 -3457.5
OR9Q1 764.5 1871.5
OR9Q2 2109.0 2023.0
REEP1 -8460.0 -17415.5
RTP1 0.5 0.5
RTP2 -1398.5 -1842.0



Beta defensins

Beta defensins
metric value
setSize 28
pMANOVA 8.15e-11
p.adjustMANOVA 3.34e-09
s.dist 0.86
s.estill 0.549
s.novakovic 0.663
p.estill 4.97e-07
p.novakovic 1.28e-09




Top 20 genes
Gene estill novakovic
DEFB119 2986.0 1585.5
TLR1 2621.0 1700.0
DEFB118 1419.0 2074.5
DEFB108B 1960.0 1419.0
DEFB105A 2324.0 0.5
CCR2 0.5 1766.5
DEFB107A 0.5 1419.0

Click HERE to show all gene set members

All member genes
estill novakovic
CCR2 0.5 1766.5
CCR6 2150.0 -2043.5
DEFB1 -926.0 -374.0
DEFB104A -837.5 -5237.0
DEFB105A 2324.0 0.5
DEFB106A -754.0 -2500.5
DEFB107A 0.5 1419.0
DEFB108B 1960.0 1419.0
DEFB115 -3883.0 -686.0
DEFB116 -3883.0 -686.0
DEFB118 1419.0 2074.5
DEFB119 2986.0 1585.5
DEFB121 -1264.0 -2379.0
DEFB123 -10230.5 2203.0
DEFB124 -4266.5 -425.0
DEFB125 -2444.5 1987.0
DEFB126 0.5 -1746.0
DEFB127 1254.0 -374.0
DEFB128 2324.0 -1230.0
DEFB129 2986.0 -5237.0
DEFB131 -2059.5 -506.5
DEFB132 -5708.5 470.0
DEFB133 -5708.5 2167.0
DEFB134 -2059.5 -2900.0
DEFB135 1684.0 -885.5
DEFB136 -3262.0 -4677.5
TLR1 2621.0 1700.0
TLR2 -3152.5 -12713.0



Defensins

Defensins
metric value
setSize 36
pMANOVA 7.16e-13
p.adjustMANOVA 4.18e-11
s.dist 0.832
s.estill 0.529
s.novakovic 0.643
p.estill 4.01e-08
p.novakovic 2.44e-11




Top 20 genes
Gene estill novakovic
DEFB119 2986.0 1585.5
TLR1 2621.0 1700.0
DEFB118 1419.0 2074.5
DEFB108B 1960.0 1419.0
DEFB105A 2324.0 0.5
DEFA3 0.5 1794.5
CCR2 0.5 1766.5
DEFB107A 0.5 1419.0

Click HERE to show all gene set members

All member genes
estill novakovic
ART1 -4266.5 -8201.0
CCR2 0.5 1766.5
CCR6 2150.0 -2043.5
CD4 -1737.5 -5657.5
DEFA1 -2059.5 2209.0
DEFA3 0.5 1794.5
DEFA4 -8838.5 1142.5
DEFA5 -3883.0 -3805.5
DEFA6 3196.0 -1230.0
DEFB1 -926.0 -374.0
DEFB104A -837.5 -5237.0
DEFB105A 2324.0 0.5
DEFB106A -754.0 -2500.5
DEFB107A 0.5 1419.0
DEFB108B 1960.0 1419.0
DEFB115 -3883.0 -686.0
DEFB116 -3883.0 -686.0
DEFB118 1419.0 2074.5
DEFB119 2986.0 1585.5
DEFB121 -1264.0 -2379.0
DEFB123 -10230.5 2203.0
DEFB124 -4266.5 -425.0
DEFB125 -2444.5 1987.0
DEFB126 0.5 -1746.0
DEFB127 1254.0 -374.0
DEFB128 2324.0 -1230.0
DEFB129 2986.0 -5237.0
DEFB131 -2059.5 -506.5
DEFB132 -5708.5 470.0
DEFB133 -5708.5 2167.0
DEFB134 -2059.5 -2900.0
DEFB135 1684.0 -885.5
DEFB136 -3262.0 -4677.5
PRSS3 2078.0 -1375.5
TLR1 2621.0 1700.0
TLR2 -3152.5 -12713.0



RUNX3 regulates p14-ARF

RUNX3 regulates p14-ARF
metric value
setSize 10
pMANOVA 0.000838
p.adjustMANOVA 0.00503
s.dist 0.798
s.estill -0.588
s.novakovic -0.539
p.estill 0.00128
p.novakovic 0.00315




Top 20 genes
Gene estill novakovic
HDAC4 -16429.5 -17028.5
RUNX3 -16007.5 -17378.5
BRD2 -15888.5 -17502.5
KRAS -12007.5 -17248.0
RUNX1 -16297.5 -10382.5
CBFB -10799.0 -15615.0
CCND1 -9660.5 -15850.5
TGFB1 -15557.5 -8687.5
CDKN2A -10230.5 -2740.5
EP300 -617.5 -7210.5

Click HERE to show all gene set members

All member genes
estill novakovic
BRD2 -15888.5 -17502.5
CBFB -10799.0 -15615.0
CCND1 -9660.5 -15850.5
CDKN2A -10230.5 -2740.5
EP300 -617.5 -7210.5
HDAC4 -16429.5 -17028.5
KRAS -12007.5 -17248.0
RUNX1 -16297.5 -10382.5
RUNX3 -16007.5 -17378.5
TGFB1 -15557.5 -8687.5



Transcriptional regulation of testis differentiation

Transcriptional regulation of testis differentiation
metric value
setSize 12
pMANOVA 0.000207
p.adjustMANOVA 0.00166
s.dist 0.789
s.estill -0.631
s.novakovic -0.474
p.estill 0.000153
p.novakovic 0.00448




Top 20 genes
Gene estill novakovic
WT1 -16139.5 -17525.5
FOXL2 -14801.0 -16938.0
FGF9 -15842.0 -15593.5
SOX9 -15179.0 -14690.0
ZFPM2 -15146.0 -13392.0
DHH -13968.0 -13936.5
AMH -10289.0 -12595.0
WNT4 -14756.0 -7862.0
DMRT1 -10893.0 -8098.5
PTGDS -13317.5 -6507.0
GATA4 -3374.5 -17385.5
NR5A1 -9649.5 -3222.5

Click HERE to show all gene set members

All member genes
estill novakovic
AMH -10289.0 -12595.0
DHH -13968.0 -13936.5
DMRT1 -10893.0 -8098.5
FGF9 -15842.0 -15593.5
FOXL2 -14801.0 -16938.0
GATA4 -3374.5 -17385.5
NR5A1 -9649.5 -3222.5
PTGDS -13317.5 -6507.0
SOX9 -15179.0 -14690.0
WNT4 -14756.0 -7862.0
WT1 -16139.5 -17525.5
ZFPM2 -15146.0 -13392.0



FOXO-mediated transcription of cell cycle genes

FOXO-mediated transcription of cell cycle genes
metric value
setSize 15
pMANOVA 1.9e-05
p.adjustMANOVA 0.000242
s.dist 0.783
s.estill -0.402
s.novakovic -0.672
p.estill 0.007
p.novakovic 6.56e-06




Top 20 genes
Gene estill novakovic
FOXG1 -16285.5 -16342.0
CDKN1B -15775.0 -14668.0
PCBP4 -14623.0 -15493.5
SMAD4 -14044.5 -15637.0
FOXO3 -12691.0 -16097.5
GADD45A -13317.5 -13088.0
CDKN1A -12493.5 -13594.0
SMAD2 -12147.0 -13187.5
BTG1 -8386.0 -17222.0
KLF4 -9079.5 -15796.5
CAV1 -8906.5 -15731.5
RBL2 -5959.0 -12696.5
FOXO1 -10724.0 -6958.5
CCNG2 -1627.0 -14213.5
SMAD3 -1386.5 -13563.5

Click HERE to show all gene set members

All member genes
estill novakovic
BTG1 -8386.0 -17222.0
CAV1 -8906.5 -15731.5
CCNG2 -1627.0 -14213.5
CDKN1A -12493.5 -13594.0
CDKN1B -15775.0 -14668.0
FOXG1 -16285.5 -16342.0
FOXO1 -10724.0 -6958.5
FOXO3 -12691.0 -16097.5
GADD45A -13317.5 -13088.0
KLF4 -9079.5 -15796.5
PCBP4 -14623.0 -15493.5
RBL2 -5959.0 -12696.5
SMAD2 -12147.0 -13187.5
SMAD3 -1386.5 -13563.5
SMAD4 -14044.5 -15637.0



Endosomal/Vacuolar pathway

Endosomal/Vacuolar pathway
metric value
setSize 10
pMANOVA 0.00142
p.adjustMANOVA 0.00754
s.dist 0.766
s.estill -0.581
s.novakovic -0.499
p.estill 0.00146
p.novakovic 0.00631




Top 20 genes
Gene estill novakovic
HLA-E -15949.5 -17411.5
HLA-H -16361.5 -16546.5
HLA-B -13597.0 -17232.5
HLA-A -14476.0 -15330.0
HLA-F -11800.5 -16141.5
HLA-C -11707.5 -16047.5
LNPEP -16238.0 -9869.5
HLA-G -10360.0 -14733.5
B2M -12336.0 -1328.0

Click HERE to show all gene set members

All member genes
estill novakovic
B2M -12336.0 -1328.0
CTSS 0.5 -969.5
HLA-A -14476.0 -15330.0
HLA-B -13597.0 -17232.5
HLA-C -11707.5 -16047.5
HLA-E -15949.5 -17411.5
HLA-F -11800.5 -16141.5
HLA-G -10360.0 -14733.5
HLA-H -16361.5 -16546.5
LNPEP -16238.0 -9869.5



Disorders of Developmental Biology

Disorders of Developmental Biology
metric value
setSize 11
pMANOVA 0.00114
p.adjustMANOVA 0.00632
s.dist 0.744
s.estill -0.506
s.novakovic -0.546
p.estill 0.00366
p.novakovic 0.00172




Top 20 genes
Gene estill novakovic
BDNF -16333.5 -16332.5
SIN3A -13066.5 -16997.0
PRKACA -15606.0 -12533.0
CAMK4 -10740.0 -17069.5
HDAC3 -11168.5 -14620.0
NCOR1 -14780.5 -10831.5
TBL1XR1 -10702.0 -13380.5
HDAC1 -10347.0 -10276.0
CALM1 -7107.5 -13376.0
NCOR2 -15097.5 -3916.5
GPS2 -1898.0 -13983.5

Click HERE to show all gene set members

All member genes
estill novakovic
BDNF -16333.5 -16332.5
CALM1 -7107.5 -13376.0
CAMK4 -10740.0 -17069.5
GPS2 -1898.0 -13983.5
HDAC1 -10347.0 -10276.0
HDAC3 -11168.5 -14620.0
NCOR1 -14780.5 -10831.5
NCOR2 -15097.5 -3916.5
PRKACA -15606.0 -12533.0
SIN3A -13066.5 -16997.0
TBL1XR1 -10702.0 -13380.5



Disorders of Nervous System Development

Disorders of Nervous System Development
metric value
setSize 11
pMANOVA 0.00114
p.adjustMANOVA 0.00632
s.dist 0.744
s.estill -0.506
s.novakovic -0.546
p.estill 0.00366
p.novakovic 0.00172




Top 20 genes
Gene estill novakovic
BDNF -16333.5 -16332.5
SIN3A -13066.5 -16997.0
PRKACA -15606.0 -12533.0
CAMK4 -10740.0 -17069.5
HDAC3 -11168.5 -14620.0
NCOR1 -14780.5 -10831.5
TBL1XR1 -10702.0 -13380.5
HDAC1 -10347.0 -10276.0
CALM1 -7107.5 -13376.0
NCOR2 -15097.5 -3916.5
GPS2 -1898.0 -13983.5

Click HERE to show all gene set members

All member genes
estill novakovic
BDNF -16333.5 -16332.5
CALM1 -7107.5 -13376.0
CAMK4 -10740.0 -17069.5
GPS2 -1898.0 -13983.5
HDAC1 -10347.0 -10276.0
HDAC3 -11168.5 -14620.0
NCOR1 -14780.5 -10831.5
NCOR2 -15097.5 -3916.5
PRKACA -15606.0 -12533.0
SIN3A -13066.5 -16997.0
TBL1XR1 -10702.0 -13380.5



Loss of function of MECP2 in Rett syndrome

Loss of function of MECP2 in Rett syndrome
metric value
setSize 11
pMANOVA 0.00114
p.adjustMANOVA 0.00632
s.dist 0.744
s.estill -0.506
s.novakovic -0.546
p.estill 0.00366
p.novakovic 0.00172




Top 20 genes
Gene estill novakovic
BDNF -16333.5 -16332.5
SIN3A -13066.5 -16997.0
PRKACA -15606.0 -12533.0
CAMK4 -10740.0 -17069.5
HDAC3 -11168.5 -14620.0
NCOR1 -14780.5 -10831.5
TBL1XR1 -10702.0 -13380.5
HDAC1 -10347.0 -10276.0
CALM1 -7107.5 -13376.0
NCOR2 -15097.5 -3916.5
GPS2 -1898.0 -13983.5

Click HERE to show all gene set members

All member genes
estill novakovic
BDNF -16333.5 -16332.5
CALM1 -7107.5 -13376.0
CAMK4 -10740.0 -17069.5
GPS2 -1898.0 -13983.5
HDAC1 -10347.0 -10276.0
HDAC3 -11168.5 -14620.0
NCOR1 -14780.5 -10831.5
NCOR2 -15097.5 -3916.5
PRKACA -15606.0 -12533.0
SIN3A -13066.5 -16997.0
TBL1XR1 -10702.0 -13380.5



Pervasive developmental disorders

Pervasive developmental disorders
metric value
setSize 11
pMANOVA 0.00114
p.adjustMANOVA 0.00632
s.dist 0.744
s.estill -0.506
s.novakovic -0.546
p.estill 0.00366
p.novakovic 0.00172




Top 20 genes
Gene estill novakovic
BDNF -16333.5 -16332.5
SIN3A -13066.5 -16997.0
PRKACA -15606.0 -12533.0
CAMK4 -10740.0 -17069.5
HDAC3 -11168.5 -14620.0
NCOR1 -14780.5 -10831.5
TBL1XR1 -10702.0 -13380.5
HDAC1 -10347.0 -10276.0
CALM1 -7107.5 -13376.0
NCOR2 -15097.5 -3916.5
GPS2 -1898.0 -13983.5

Click HERE to show all gene set members

All member genes
estill novakovic
BDNF -16333.5 -16332.5
CALM1 -7107.5 -13376.0
CAMK4 -10740.0 -17069.5
GPS2 -1898.0 -13983.5
HDAC1 -10347.0 -10276.0
HDAC3 -11168.5 -14620.0
NCOR1 -14780.5 -10831.5
NCOR2 -15097.5 -3916.5
PRKACA -15606.0 -12533.0
SIN3A -13066.5 -16997.0
TBL1XR1 -10702.0 -13380.5



eNOS activation

eNOS activation
metric value
setSize 11
pMANOVA 0.000587
p.adjustMANOVA 0.00388
s.dist 0.73
s.estill -0.669
s.novakovic -0.293
p.estill 0.000123
p.novakovic 0.0921




Top 20 genes
Gene estill novakovic
DDAH1 -15241.5 -17330.5
SPR -15225.5 -15430.5
NOS3 -15053.5 -10270.5
HSP90AA1 -15043.5 -10196.5
CAV1 -8906.5 -15731.5
DDAH2 -16295.0 -8020.5
LYPLA1 -14584.5 -8764.5
CALM1 -7107.5 -13376.0
AKT1 -14329.5 -4528.0
ZDHHC21 -6759.0 -8867.5
CYGB -16132.0 -3124.0

Click HERE to show all gene set members

All member genes
estill novakovic
AKT1 -14329.5 -4528.0
CALM1 -7107.5 -13376.0
CAV1 -8906.5 -15731.5
CYGB -16132.0 -3124.0
DDAH1 -15241.5 -17330.5
DDAH2 -16295.0 -8020.5
HSP90AA1 -15043.5 -10196.5
LYPLA1 -14584.5 -8764.5
NOS3 -15053.5 -10270.5
SPR -15225.5 -15430.5
ZDHHC21 -6759.0 -8867.5



mRNA Editing

mRNA Editing
metric value
setSize 10
pMANOVA 0.00407
p.adjustMANOVA 0.0167
s.dist 0.703
s.estill 0.517
s.novakovic 0.477
p.estill 0.00461
p.novakovic 0.00906




Top 20 genes
Gene estill novakovic
APOBEC3A 2109 1480.0
APOBEC1 3196 0.5

Click HERE to show all gene set members

All member genes
estill novakovic
A1CF 0.5 -7500.5
ADAR -9122.0 -10083.5
ADARB1 -3547.0 -8064.5
APOBEC1 3196.0 0.5
APOBEC2 688.0 -3248.0
APOBEC3A 2109.0 1480.0
APOBEC3B -4266.5 1096.0
APOBEC3C 0.5 -951.0
APOBEC3H -630.5 -567.5
APOBEC4 -1771.0 -567.5



Antimicrobial peptides

Antimicrobial peptides
metric value
setSize 69
pMANOVA 1.04e-17
p.adjustMANOVA 8.33e-16
s.dist 0.699
s.estill 0.383
s.novakovic 0.585
p.estill 3.76e-08
p.novakovic 4.1e-17




Top 20 genes
Gene estill novakovic
RNASE7 2847.5 2159.5
DEFB119 2986.0 1585.5
TLR1 2621.0 1700.0
DEFB118 1419.0 2074.5
DEFB108B 1960.0 1419.0
REG3G 854.0 900.5
DEFB105A 2324.0 0.5
RNASE3 2324.0 0.5
LYZ 0.5 1923.5
PI3 0.5 1923.5
DEFA3 0.5 1794.5
CCR2 0.5 1766.5
DEFB107A 0.5 1419.0
SEMG1 0.5 0.5

Click HERE to show all gene set members

All member genes
estill novakovic
ART1 -4266.5 -8201.0
ATOX1 -7968.5 -12269.5
BPI -12421.5 1542.5
CAMP -4266.5 -589.0
CCR2 0.5 1766.5
CCR6 2150.0 -2043.5
CD4 -1737.5 -5657.5
CHGA -13805.5 -13431.5
CLU -11895.5 -13235.5
CTSG -2710.0 1857.0
DCD -1771.0 419.5
DEFA1 -2059.5 2209.0
DEFA3 0.5 1794.5
DEFA4 -8838.5 1142.5
DEFA5 -3883.0 -3805.5
DEFA6 3196.0 -1230.0
DEFB1 -926.0 -374.0
DEFB104A -837.5 -5237.0
DEFB105A 2324.0 0.5
DEFB106A -754.0 -2500.5
DEFB107A 0.5 1419.0
DEFB108B 1960.0 1419.0
DEFB115 -3883.0 -686.0
DEFB116 -3883.0 -686.0
DEFB118 1419.0 2074.5
DEFB119 2986.0 1585.5
DEFB121 -1264.0 -2379.0
DEFB123 -10230.5 2203.0
DEFB124 -4266.5 -425.0
DEFB125 -2444.5 1987.0
DEFB126 0.5 -1746.0
DEFB127 1254.0 -374.0
DEFB128 2324.0 -1230.0
DEFB129 2986.0 -5237.0
DEFB131 -2059.5 -506.5
DEFB132 -5708.5 470.0
DEFB133 -5708.5 2167.0
DEFB134 -2059.5 -2900.0
DEFB135 1684.0 -885.5
DEFB136 -3262.0 -4677.5
ELANE -10347.0 1662.5
GNLY -1717.5 330.5
ITLN1 2621.0 -885.5
LCN2 -7328.5 0.5
LEAP2 3365.5 -9228.0
LTF -13012.0 -13712.5
LYZ 0.5 1923.5
PGLYRP1 -14584.5 -12898.5
PGLYRP2 -7237.5 -1380.5
PGLYRP3 3196.0 -3248.0
PGLYRP4 -1264.0 -2393.0
PI3 0.5 1923.5
PLA2G2A -8386.0 1037.5
PRSS3 2078.0 -1375.5
PRTN3 -16118.0 2258.5
REG3A 3196.0 -3028.0
REG3G 854.0 900.5
RNASE3 2324.0 0.5
RNASE6 0.5 -2137.0
RNASE7 2847.5 2159.5
RNASE8 2442.0 -4814.5
S100A7 -2059.5 -2237.0
S100A7A -630.5 -545.0
S100A8 -5101.0 453.5
S100A9 -6302.0 933.5
SEMG1 0.5 0.5
SLC11A1 -12966.0 -1022.5
TLR1 2621.0 1700.0
TLR2 -3152.5 -12713.0



Repression of WNT target genes

Repression of WNT target genes
metric value
setSize 13
pMANOVA 0.000367
p.adjustMANOVA 0.00264
s.dist 0.677
s.estill -0.23
s.novakovic -0.637
p.estill 0.151
p.novakovic 6.98e-05




Top 20 genes
Gene estill novakovic
TCF7 -15749.0 -17529.5
AXIN2 -10658.5 -16058.5
TLE3 -10312.5 -16008.5
MYC -9968.0 -15281.5
TLE4 -8238.5 -14666.0
HDAC1 -10347.0 -10276.0
CTBP2 -5887.5 -17173.5
TLE1 -6639.0 -14421.0
TCF7L1 -6171.5 -14830.5
TLE2 -7546.5 -12082.5
LEF1 -6670.0 -13535.5
TCF7L2 -5196.5 -13975.5
CTBP1 -10753.5 -5338.5

Click HERE to show all gene set members

All member genes
estill novakovic
AXIN2 -10658.5 -16058.5
CTBP1 -10753.5 -5338.5
CTBP2 -5887.5 -17173.5
HDAC1 -10347.0 -10276.0
LEF1 -6670.0 -13535.5
MYC -9968.0 -15281.5
TCF7 -15749.0 -17529.5
TCF7L1 -6171.5 -14830.5
TCF7L2 -5196.5 -13975.5
TLE1 -6639.0 -14421.0
TLE2 -7546.5 -12082.5
TLE3 -10312.5 -16008.5
TLE4 -8238.5 -14666.0



Defective B4GALT7 causes EDS, progeroid type

Defective B4GALT7 causes EDS, progeroid type
metric value
setSize 17
pMANOVA 8.16e-05
p.adjustMANOVA 0.00082
s.dist 0.675
s.estill -0.597
s.novakovic -0.314
p.estill 2e-05
p.novakovic 0.025




Top 20 genes
Gene estill novakovic
GPC5 -15928.5 -16106.5
VCAN -15201.5 -16032.5
SDC3 -14325.0 -16259.5
AGRN -16378.5 -13627.5
SDC1 -15680.0 -12442.5
GPC1 -15708.5 -12289.0
BCAN -13049.5 -11695.5
SDC2 -8031.0 -17012.0
GPC2 -12467.0 -10950.5
NCAN -15371.0 -8677.5
HSPG2 -12862.5 -9841.5
B4GALT7 -13991.0 -8388.0
GPC6 -7655.5 -10194.5
CSPG5 -9008.5 -7373.0
CSPG4 -16269.0 -3577.5
SDC4 -7505.0 -4535.5
DCN -2059.5 -3204.5

Click HERE to show all gene set members

All member genes
estill novakovic
AGRN -16378.5 -13627.5
B4GALT7 -13991.0 -8388.0
BCAN -13049.5 -11695.5
CSPG4 -16269.0 -3577.5
CSPG5 -9008.5 -7373.0
DCN -2059.5 -3204.5
GPC1 -15708.5 -12289.0
GPC2 -12467.0 -10950.5
GPC5 -15928.5 -16106.5
GPC6 -7655.5 -10194.5
HSPG2 -12862.5 -9841.5
NCAN -15371.0 -8677.5
SDC1 -15680.0 -12442.5
SDC2 -8031.0 -17012.0
SDC3 -14325.0 -16259.5
SDC4 -7505.0 -4535.5
VCAN -15201.5 -16032.5



Defective B3GAT3 causes JDSSDHD

Defective B3GAT3 causes JDSSDHD
metric value
setSize 17
pMANOVA 8.4e-05
p.adjustMANOVA 0.00083
s.dist 0.672
s.estill -0.598
s.novakovic -0.308
p.estill 1.98e-05
p.novakovic 0.0281




Top 20 genes
Gene estill novakovic
GPC5 -15928.5 -16106.5
VCAN -15201.5 -16032.5
SDC3 -14325.0 -16259.5
AGRN -16378.5 -13627.5
SDC1 -15680.0 -12442.5
GPC1 -15708.5 -12289.0
BCAN -13049.5 -11695.5
SDC2 -8031.0 -17012.0
GPC2 -12467.0 -10950.5
NCAN -15371.0 -8677.5
HSPG2 -12862.5 -9841.5
B3GAT3 -14044.5 -7304.5
GPC6 -7655.5 -10194.5
CSPG5 -9008.5 -7373.0
CSPG4 -16269.0 -3577.5
SDC4 -7505.0 -4535.5
DCN -2059.5 -3204.5

Click HERE to show all gene set members

All member genes
estill novakovic
AGRN -16378.5 -13627.5
B3GAT3 -14044.5 -7304.5
BCAN -13049.5 -11695.5
CSPG4 -16269.0 -3577.5
CSPG5 -9008.5 -7373.0
DCN -2059.5 -3204.5
GPC1 -15708.5 -12289.0
GPC2 -12467.0 -10950.5
GPC5 -15928.5 -16106.5
GPC6 -7655.5 -10194.5
HSPG2 -12862.5 -9841.5
NCAN -15371.0 -8677.5
SDC1 -15680.0 -12442.5
SDC2 -8031.0 -17012.0
SDC3 -14325.0 -16259.5
SDC4 -7505.0 -4535.5
VCAN -15201.5 -16032.5



Crosslinking of collagen fibrils

Crosslinking of collagen fibrils
metric value
setSize 10
pMANOVA 0.00451
p.adjustMANOVA 0.018
s.dist 0.66
s.estill -0.288
s.novakovic -0.594
p.estill 0.114
p.novakovic 0.00114




Top 20 genes
Gene estill novakovic
TLL1 -15674.5 -17209.5
TLL2 -15639.5 -17244.5
LOXL1 -16316.5 -13918.5
PCOLCE -12088.5 -14810.0
LOXL3 -8323.0 -17404.5
LOXL2 -11327.5 -11824.5
LOXL4 -8770.0 -6953.0
BMP1 -6169.0 -6686.0
LOX -950.5 -14063.5

Click HERE to show all gene set members

All member genes
estill novakovic
BMP1 -6169.0 -6686.0
LOX -950.5 -14063.5
LOXL1 -16316.5 -13918.5
LOXL2 -11327.5 -11824.5
LOXL3 -8323.0 -17404.5
LOXL4 -8770.0 -6953.0
PCOLCE -12088.5 -14810.0
PXDN 1629.5 -14989.5
TLL1 -15674.5 -17209.5
TLL2 -15639.5 -17244.5



Interaction With Cumulus Cells And The Zona Pellucida

Interaction With Cumulus Cells And The Zona Pellucida
metric value
setSize 11
pMANOVA 0.00489
p.adjustMANOVA 0.0191
s.dist 0.654
s.estill 0.517
s.novakovic 0.401
p.estill 0.00298
p.novakovic 0.0213




Top 20 genes
Gene estill novakovic
ADAM30 2063 2279.5
SPAM1 1084 1621.0
ADAM21 1960 419.5
ZP2 854 933.5

Click HERE to show all gene set members

All member genes
estill novakovic
ADAM2 -8003.0 -7199.5
ADAM20 0.5 -5237.0
ADAM21 1960.0 419.5
ADAM30 2063.0 2279.5
B4GALT1 -4828.5 -10791.5
OVGP1 0.5 -5404.0
SPAM1 1084.0 1621.0
ZP1 -5101.0 -4473.5
ZP2 854.0 933.5
ZP3 -5932.5 -3107.5
ZP4 3196.0 -8566.5



Defective EXT1 causes exostoses 1, TRPS2 and CHDS

Defective EXT1 causes exostoses 1, TRPS2 and CHDS
metric value
setSize 12
pMANOVA 0.00359
p.adjustMANOVA 0.015
s.dist 0.648
s.estill -0.423
s.novakovic -0.491
p.estill 0.0113
p.novakovic 0.0032




Top 20 genes
Gene estill novakovic
GPC5 -15928.5 -16106.5
SDC3 -14325.0 -16259.5
AGRN -16378.5 -13627.5
SDC1 -15680.0 -12442.5
GPC1 -15708.5 -12289.0
SDC2 -8031.0 -17012.0
GPC2 -12467.0 -10950.5
HSPG2 -12862.5 -9841.5
GPC6 -7655.5 -10194.5
SDC4 -7505.0 -4535.5
EXT2 -3336.0 -9442.5

Click HERE to show all gene set members

All member genes
estill novakovic
AGRN -16378.5 -13627.5
EXT1 1471.5 -17136.5
EXT2 -3336.0 -9442.5
GPC1 -15708.5 -12289.0
GPC2 -12467.0 -10950.5
GPC5 -15928.5 -16106.5
GPC6 -7655.5 -10194.5
HSPG2 -12862.5 -9841.5
SDC1 -15680.0 -12442.5
SDC2 -8031.0 -17012.0
SDC3 -14325.0 -16259.5
SDC4 -7505.0 -4535.5



Defective EXT2 causes exostoses 2

Defective EXT2 causes exostoses 2
metric value
setSize 12
pMANOVA 0.00359
p.adjustMANOVA 0.015
s.dist 0.648
s.estill -0.423
s.novakovic -0.491
p.estill 0.0113
p.novakovic 0.0032




Top 20 genes
Gene estill novakovic
GPC5 -15928.5 -16106.5
SDC3 -14325.0 -16259.5
AGRN -16378.5 -13627.5
SDC1 -15680.0 -12442.5
GPC1 -15708.5 -12289.0
SDC2 -8031.0 -17012.0
GPC2 -12467.0 -10950.5
HSPG2 -12862.5 -9841.5
GPC6 -7655.5 -10194.5
SDC4 -7505.0 -4535.5
EXT2 -3336.0 -9442.5

Click HERE to show all gene set members

All member genes
estill novakovic
AGRN -16378.5 -13627.5
EXT1 1471.5 -17136.5
EXT2 -3336.0 -9442.5
GPC1 -15708.5 -12289.0
GPC2 -12467.0 -10950.5
GPC5 -15928.5 -16106.5
GPC6 -7655.5 -10194.5
HSPG2 -12862.5 -9841.5
SDC1 -15680.0 -12442.5
SDC2 -8031.0 -17012.0
SDC3 -14325.0 -16259.5
SDC4 -7505.0 -4535.5



Glucuronidation

Glucuronidation
metric value
setSize 19
pMANOVA 0.000131
p.adjustMANOVA 0.00117
s.dist 0.646
s.estill 0.509
s.novakovic 0.398
p.estill 0.000123
p.novakovic 0.00269




Top 20 genes
Gene estill novakovic
UGT1A4 3436.5 1557.5
UGT1A5 3379.5 1297.5
UGT1A3 3423.5 1063.5
UGT1A1 2477.0 380.5
UGT2B11 0.5 852.5

Click HERE to show all gene set members

All member genes
estill novakovic
ABHD10 1806.5 -11547.5
SLC35D1 -13109.0 -7881.0
UGDH -11875.5 -14445.0
UGP2 -10396.5 -13776.5
UGT1A1 2477.0 380.5
UGT1A10 3466.5 -616.5
UGT1A3 3423.5 1063.5
UGT1A4 3436.5 1557.5
UGT1A5 3379.5 1297.5
UGT1A6 3464.5 -412.5
UGT1A7 3471.5 -612.5
UGT1A8 3465.5 -1075.5
UGT1A9 3446.5 -797.5
UGT2B11 0.5 852.5
UGT2B15 -8003.0 1746.5
UGT2B17 -3883.0 -1230.0
UGT2B4 -2059.5 -5237.0
UGT3A1 -1131.5 -10576.0
UGT3A2 -8386.0 -7642.5



Metabolism of nitric oxide: NOS3 activation and regulation

Metabolism of nitric oxide: NOS3 activation and regulation
metric value
setSize 15
pMANOVA 0.000401
p.adjustMANOVA 0.00285
s.dist 0.633
s.estill -0.589
s.novakovic -0.231
p.estill 7.79e-05
p.novakovic 0.121




Top 20 genes
Gene estill novakovic
DDAH1 -15241.5 -17330.5
WASL -14044.5 -17034.5
SPR -15225.5 -15430.5
DNM2 -13405.0 -16430.5
NOS3 -15053.5 -10270.5
HSP90AA1 -15043.5 -10196.5
CAV1 -8906.5 -15731.5
DDAH2 -16295.0 -8020.5
LYPLA1 -14584.5 -8764.5
CALM1 -7107.5 -13376.0
AKT1 -14329.5 -4528.0
ZDHHC21 -6759.0 -8867.5
CYGB -16132.0 -3124.0
NOSIP -15663.0 -1041.5

Click HERE to show all gene set members

All member genes
estill novakovic
AKT1 -14329.5 -4528.0
CALM1 -7107.5 -13376.0
CAV1 -8906.5 -15731.5
CYGB -16132.0 -3124.0
DDAH1 -15241.5 -17330.5
DDAH2 -16295.0 -8020.5
DNM2 -13405.0 -16430.5
HSP90AA1 -15043.5 -10196.5
LYPLA1 -14584.5 -8764.5
NOS3 -15053.5 -10270.5
NOSIP -15663.0 -1041.5
NOSTRIN 2405.5 1741.5
SPR -15225.5 -15430.5
WASL -14044.5 -17034.5
ZDHHC21 -6759.0 -8867.5



HS-GAG degradation

HS-GAG degradation
metric value
setSize 18
pMANOVA 0.000315
p.adjustMANOVA 0.00234
s.dist 0.622
s.estill -0.518
s.novakovic -0.345
p.estill 0.000142
p.novakovic 0.0112




Top 20 genes
Gene estill novakovic
IDUA -16416.5 -16427.5
GPC5 -15928.5 -16106.5
SDC3 -14325.0 -16259.5
AGRN -16378.5 -13627.5
HPSE2 -16090.5 -12543.5
SDC1 -15680.0 -12442.5
GPC1 -15708.5 -12289.0
SDC2 -8031.0 -17012.0
GPC2 -12467.0 -10950.5
HSPG2 -12862.5 -9841.5
SGSH -8067.5 -10849.5
GPC6 -7655.5 -10194.5
GLB1 -5380.0 -14418.0
NAGLU -10101.0 -5782.0
GLB1L -4192.0 -10437.5
GUSB -14936.0 -2620.0
SDC4 -7505.0 -4535.5
HPSE -7937.5 -2227.5

Click HERE to show all gene set members

All member genes
estill novakovic
AGRN -16378.5 -13627.5
GLB1 -5380.0 -14418.0
GLB1L -4192.0 -10437.5
GPC1 -15708.5 -12289.0
GPC2 -12467.0 -10950.5
GPC5 -15928.5 -16106.5
GPC6 -7655.5 -10194.5
GUSB -14936.0 -2620.0
HPSE -7937.5 -2227.5
HPSE2 -16090.5 -12543.5
HSPG2 -12862.5 -9841.5
IDUA -16416.5 -16427.5
NAGLU -10101.0 -5782.0
SDC1 -15680.0 -12442.5
SDC2 -8031.0 -17012.0
SDC3 -14325.0 -16259.5
SDC4 -7505.0 -4535.5
SGSH -8067.5 -10849.5



Keratinization

Keratinization
metric value
setSize 197
pMANOVA 1.3e-36
p.adjustMANOVA 3.96e-34
s.dist 0.615
s.estill 0.408
s.novakovic 0.461
p.estill 5.51e-23
p.novakovic 6.53e-29




Top 20 genes
Gene estill novakovic
KRTAP5-7 2873.5 2074.5
SPRR2B 2621.0 1987.0
SPRR2D 2986.0 1585.5
KRTAP4-7 1960.0 2039.5
LCE6A 3065.5 1072.5
KRT6A 1483.5 2010.5
KRTAP19-4 1960.0 1419.0
SPRR2E 1960.0 1419.0
KRT25 1575.0 1585.5
LCE2B 2324.0 1001.5
LELP1 1325.5 1700.0
KRTAP8-1 1960.0 1142.5
KRTAP10-8 2621.0 713.5
KRTAP4-8 854.0 2074.5
LCE1A 854.0 1585.5
KRTAP1-5 2986.0 419.5
SPRR3 964.5 1288.5
LIPJ 2621.0 470.0
KRTAP5-8 1419.0 619.5
LCE4A 2324.0 0.5

Click HERE to show all gene set members

All member genes
estill novakovic
CAPN1 -9943.0 -17243.0
CAPNS1 -3135.0 -5608.0
CASP14 3196.0 -328.0
CDSN -12147.0 -2338.5
CELA2A 854.0 -2461.0
CSTA -2059.5 2238.5
DSC1 1960.0 -8277.5
DSC2 -8838.5 -14362.5
DSC3 -14623.0 -16812.5
DSG1 0.5 -7167.5
DSG2 -6881.5 408.0
DSG3 -2059.5 -1987.5
DSP -13137.0 -13626.5
EVPL -14219.5 -4797.5
FLG -2824.0 -623.0
FURIN -12844.0 -14078.0
IVL -1264.0 -12098.0
JUP -11101.5 -5614.5
KLK12 -4828.5 518.5
KLK13 -2226.5 -7609.0
KLK14 -4266.5 0.5
KLK5 1419.0 -3588.0
KLK8 -14044.5 -3653.0
KRT1 3053.5 -3002.5
KRT10 -3262.0 -5109.0
KRT12 -3419.0 2103.0
KRT13 -4266.5 -2830.0
KRT14 -12421.5 1235.0
KRT15 -7616.5 -7292.0
KRT16 -6759.0 -1093.0
KRT17 -10230.5 1669.5
KRT18 -13658.0 -4535.5
KRT19 -14149.5 -7597.0
KRT2 2490.0 -3992.0
KRT20 -2288.0 -1526.5
KRT23 -1680.5 -2253.0
KRT24 -1509.0 -4003.5
KRT25 1575.0 1585.5
KRT26 -1509.0 -6414.0
KRT27 -697.5 -2952.0
KRT28 -3262.0 330.5
KRT3 -979.5 -9754.5
KRT31 964.5 -2500.5
KRT32 -8838.5 1245.0
KRT33A -2824.0 -8032.0
KRT33B 2324.0 -5571.0
KRT34 -1264.0 -3213.5
KRT35 -2710.0 -2805.5
KRT36 -1834.0 -630.5
KRT37 0.5 -7922.0
KRT38 2442.0 -2500.5
KRT39 2621.0 -4814.5
KRT4 -8386.0 -2975.0
KRT40 1419.0 -2253.0
KRT5 -5799.0 500.5
KRT6A 1483.5 2010.5
KRT6B 0.5 1001.5
KRT6C 964.5 -1828.0
KRT7 -15730.5 -13502.0
KRT71 -6759.0 503.0
KRT72 -7259.5 -4295.5
KRT73 -3262.0 -3002.5
KRT74 -8838.5 1209.5
KRT75 -11396.5 2327.5
KRT76 -5101.0 -860.0
KRT77 1506.0 -6300.5
KRT78 -11817.0 -5804.0
KRT79 -6759.0 -4121.0
KRT8 -11345.0 -6625.5
KRT80 -15716.5 -3913.0
KRT81 -9079.5 -897.5
KRT82 -10230.5 -642.0
KRT83 -12421.5 -874.0
KRT84 -1509.0 -1526.5
KRT85 -10678.5 1215.0
KRT86 -9926.0 -13642.0
KRT9 -14044.5 1881.0
KRTAP1-1 0.5 -5237.0
KRTAP1-3 0.5 713.5
KRTAP1-5 2986.0 419.5
KRTAP10-1 -2824.0 -393.0
KRTAP10-10 -6759.0 -5571.0
KRTAP10-11 -1509.0 -3064.5
KRTAP10-12 -1509.0 -6414.0
KRTAP10-2 -3262.0 -12098.0
KRTAP10-3 0.5 -1481.5
KRTAP10-4 0.5 -4677.5
KRTAP10-5 -1082.0 0.5
KRTAP10-6 -2059.5 -885.5
KRTAP10-7 -1264.0 -3608.0
KRTAP10-8 2621.0 713.5
KRTAP10-9 2324.0 -7434.5
KRTAP11-1 2741.5 -4814.5
KRTAP12-1 0.5 -3064.5
KRTAP12-2 -754.0 -6828.5
KRTAP12-3 -7328.5 -425.0
KRTAP12-4 -2059.5 -2900.0
KRTAP13-1 1254.0 -2900.0
KRTAP13-2 -754.0 1700.0
KRTAP13-3 1575.0 -1129.0
KRTAP13-4 0.5 -2900.0
KRTAP15-1 0.5 -5237.0
KRTAP17-1 2371.0 -11471.5
KRTAP19-1 -2059.5 0.5
KRTAP19-2 0.5 0.5
KRTAP19-3 -5708.5 -860.0
KRTAP19-4 1960.0 1419.0
KRTAP19-5 -2444.5 -6326.0
KRTAP19-7 0.5 -1746.0
KRTAP19-8 2621.0 -2900.0
KRTAP2-1 -3262.0 -4677.5
KRTAP2-2 0.5 -5237.0
KRTAP2-4 1254.0 -5925.0
KRTAP20-1 0.5 -3457.5
KRTAP22-1 -3883.0 -2137.0
KRTAP23-1 1960.0 0.5
KRTAP24-1 -837.5 -7811.5
KRTAP25-1 -2059.5 0.5
KRTAP26-1 1960.0 -8277.5
KRTAP27-1 1960.0 -6326.0
KRTAP3-1 1960.0 -9711.0
KRTAP3-2 2986.0 -2137.0
KRTAP3-3 0.5 0.5
KRTAP4-1 -2059.5 -8277.5
KRTAP4-11 1960.0 0.5
KRTAP4-2 2621.0 -5237.0
KRTAP4-3 1575.0 -1230.0
KRTAP4-4 0.5 1142.5
KRTAP4-5 2986.0 -2137.0
KRTAP4-7 1960.0 2039.5
KRTAP4-8 854.0 2074.5
KRTAP4-9 1960.0 0.5
KRTAP5-1 0.5 1419.0
KRTAP5-10 0.5 0.5
KRTAP5-11 1084.0 -686.0
KRTAP5-2 -5708.5 -5571.0
KRTAP5-3 -1509.0 -1093.0
KRTAP5-4 -1082.0 0.5
KRTAP5-5 -8838.5 -4105.5
KRTAP5-6 -1082.0 2074.5
KRTAP5-7 2873.5 2074.5
KRTAP5-8 1419.0 619.5
KRTAP5-9 -10230.5 -9976.0
KRTAP6-1 0.5 0.5
KRTAP6-2 0.5 541.0
KRTAP6-3 2986.0 -2137.0
KRTAP8-1 1960.0 1142.5
KRTAP9-2 2986.0 -1230.0
KRTAP9-3 1960.0 -996.5
KRTAP9-4 0.5 -8277.5
KRTAP9-8 0.5 -1746.0
KRTAP9-9 0.5 -6229.0
LCE1A 854.0 1585.5
LCE1B 854.0 -3805.5
LCE1C 1575.0 -686.0
LCE1D 0.5 -818.0
LCE1E -3262.0 1669.5
LCE1F -5708.5 1142.5
LCE2A 1419.0 -1481.5
LCE2B 2324.0 1001.5
LCE2C -1509.0 -5237.0
LCE2D -2059.5 -686.0
LCE3A -4548.5 1923.5
LCE3D 1960.0 -506.5
LCE3E 854.0 -686.0
LCE4A 2324.0 0.5
LCE5A -5708.5 -1539.5
LCE6A 3065.5 1072.5
LELP1 1325.5 1700.0
LIPJ 2621.0 470.0
LIPK 2621.0 -5571.0
LIPM 0.5 -8277.5
PCSK6 -2320.5 -9963.5
PERP -4134.5 -14523.0
PI3 0.5 1923.5
PKP1 -9566.0 -13849.5
PKP2 -9845.5 363.5
PKP3 -7426.0 -7587.0
PKP4 -5783.0 -11579.5
PPL -4370.5 -10540.0
PRSS8 -9145.5 -476.5
RPTN 854.0 -4588.0
SPINK5 -3883.0 -12713.0
SPINK9 0.5 -3457.5
SPRR1A 2741.5 -374.0
SPRR1B -1082.0 1142.5
SPRR2A 1575.0 -2137.0
SPRR2B 2621.0 1987.0
SPRR2D 2986.0 1585.5
SPRR2E 1960.0 1419.0
SPRR2F -2059.5 -996.5
SPRR2G 0.5 1527.0
SPRR3 964.5 1288.5
ST14 -5770.5 -910.5
TCHH 1708.5 -3954.5
TGM1 -10032.0 1337.0
TGM5 -1208.5 -1066.5



Defective B3GALT6 causes EDSP2 and SEMDJL1

Defective B3GALT6 causes EDSP2 and SEMDJL1
metric value
setSize 17
pMANOVA 0.000453
p.adjustMANOVA 0.00311
s.dist 0.609
s.estill -0.541
s.novakovic -0.281
p.estill 0.000113
p.novakovic 0.0448




Top 20 genes
Gene estill novakovic
GPC5 -15928.5 -16106.5
VCAN -15201.5 -16032.5
SDC3 -14325.0 -16259.5
AGRN -16378.5 -13627.5
SDC1 -15680.0 -12442.5
GPC1 -15708.5 -12289.0
BCAN -13049.5 -11695.5
SDC2 -8031.0 -17012.0
GPC2 -12467.0 -10950.5
NCAN -15371.0 -8677.5
HSPG2 -12862.5 -9841.5
GPC6 -7655.5 -10194.5
CSPG5 -9008.5 -7373.0
CSPG4 -16269.0 -3577.5
SDC4 -7505.0 -4535.5
B3GALT6 -4426.0 -2805.5
DCN -2059.5 -3204.5

Click HERE to show all gene set members

All member genes
estill novakovic
AGRN -16378.5 -13627.5
B3GALT6 -4426.0 -2805.5
BCAN -13049.5 -11695.5
CSPG4 -16269.0 -3577.5
CSPG5 -9008.5 -7373.0
DCN -2059.5 -3204.5
GPC1 -15708.5 -12289.0
GPC2 -12467.0 -10950.5
GPC5 -15928.5 -16106.5
GPC6 -7655.5 -10194.5
HSPG2 -12862.5 -9841.5
NCAN -15371.0 -8677.5
SDC1 -15680.0 -12442.5
SDC2 -8031.0 -17012.0
SDC3 -14325.0 -16259.5
SDC4 -7505.0 -4535.5
VCAN -15201.5 -16032.5



Translocation of ZAP-70 to Immunological synapse

Translocation of ZAP-70 to Immunological synapse
metric value
setSize 17
pMANOVA 0.000763
p.adjustMANOVA 0.00469
s.dist 0.605
s.estill 0.5
s.novakovic 0.341
p.estill 0.000353
p.novakovic 0.015




Top 20 genes
Gene estill novakovic
HLA-DQB2 3474.5 2373.5
HLA-DQA1 2183.5 976.0

Click HERE to show all gene set members

All member genes
estill novakovic
CD247 -13646.5 -11684.5
CD3D -6008.0 -13143.0
CD3E 964.5 -1129.0
CD3G -1131.5 -9325.0
CD4 -1737.5 -5657.5
HLA-DPA1 3410.5 -621.5
HLA-DPB1 3223.5 -2837.5
HLA-DQA1 2183.5 976.0
HLA-DQA2 3455.5 -1860.0
HLA-DQB1 -12099.5 -10761.0
HLA-DQB2 3474.5 2373.5
HLA-DRA 3388.5 -2246.0
HLA-DRB1 -2272.0 2332.5
HLA-DRB5 1700.0 -1553.0
LCK -5144.0 -6604.5
PTPN22 1084.0 -3583.5
ZAP70 -6421.5 -6007.5



NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus
metric value
setSize 11
pMANOVA 0.00433
p.adjustMANOVA 0.0175
s.dist 0.598
s.estill -0.171
s.novakovic -0.574
p.estill 0.327
p.novakovic 0.000987




Top 20 genes
Gene estill novakovic
NOTCH4 -15914.5 -17546.5
YWHAZ -14494.5 -14714.5
JAG1 -13137.0 -15261.5
APH1B -13920.0 -5702.5
APH1A -12336.0 -5811.0
ADAM10 -4458.5 -15909.0
NCSTN -4036.0 -16262.0
DLL4 -4076.5 -14394.5
PSENEN -3763.5 -13355.5
PSEN1 -2738.0 -13696.5
PSEN2 -1208.5 -13710.5

Click HERE to show all gene set members

All member genes
estill novakovic
ADAM10 -4458.5 -15909.0
APH1A -12336.0 -5811.0
APH1B -13920.0 -5702.5
DLL4 -4076.5 -14394.5
JAG1 -13137.0 -15261.5
NCSTN -4036.0 -16262.0
NOTCH4 -15914.5 -17546.5
PSEN1 -2738.0 -13696.5
PSEN2 -1208.5 -13710.5
PSENEN -3763.5 -13355.5
YWHAZ -14494.5 -14714.5



TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
metric value
setSize 14
pMANOVA 0.00431
p.adjustMANOVA 0.0175
s.dist 0.587
s.estill -0.361
s.novakovic -0.463
p.estill 0.0193
p.novakovic 0.0027




Top 20 genes
Gene estill novakovic
CCNA1 -16358.5 -16667.5
CDKN1B -15775.0 -14668.0
PCBP4 -14623.0 -15493.5
E2F1 -14400.0 -14317.0
E2F8 -11462.0 -16407.0
CDKN1A -12493.5 -13594.0
ZNF385A -15067.0 -8619.5
CCNE1 -7823.5 -13927.5
CCNA2 -6577.0 -13355.5
E2F7 -7001.5 -9258.5
TP53 -5934.5 -10080.5
ARID3A -8993.5 -4743.5
CCNE2 -6099.0 -5804.0

Click HERE to show all gene set members

All member genes
estill novakovic
ARID3A -8993.5 -4743.5
CCNA1 -16358.5 -16667.5
CCNA2 -6577.0 -13355.5
CCNE1 -7823.5 -13927.5
CCNE2 -6099.0 -5804.0
CDK2 1374.5 -13908.0
CDKN1A -12493.5 -13594.0
CDKN1B -15775.0 -14668.0
E2F1 -14400.0 -14317.0
E2F7 -7001.5 -9258.5
E2F8 -11462.0 -16407.0
PCBP4 -14623.0 -15493.5
TP53 -5934.5 -10080.5
ZNF385A -15067.0 -8619.5



Aspirin ADME

Aspirin ADME
metric value
setSize 36
pMANOVA 1.54e-06
p.adjustMANOVA 2.54e-05
s.dist 0.576
s.estill 0.442
s.novakovic 0.371
p.estill 4.51e-06
p.novakovic 0.000119




Top 20 genes
Gene estill novakovic
UGT1A4 3436.5 1557.5
UGT1A5 3379.5 1297.5
UGT1A3 3423.5 1063.5
UGT1A1 2477.0 380.5
GLYAT 1084.0 810.5
CYP3A4 2873.5 0.5
ACSM4 0.5 1088.0
UGT2B11 0.5 852.5

Click HERE to show all gene set members

All member genes
estill novakovic
ABCC2 -3096.0 -4420.0
ABCC3 -13968.0 -10593.5
ACSM2A 0.5 -818.0
ACSM4 0.5 1088.0
ACSM5 3294.0 -4505.5
ALB -2059.5 -7337.5
BCHE 0.5 -9711.0
BSG -8690.0 -11024.0
CES1 -1920.0 2329.5
CES2 -11943.5 -12983.0
CYP2C19 0.5 -6326.0
CYP2C9 1254.0 -1230.0
CYP2D6 -11817.0 -4231.0
CYP2E1 -15426.0 -14668.0
CYP3A4 2873.5 0.5
GLYAT 1084.0 810.5
GLYATL1 854.0 -2268.0
GLYATL2 -1082.0 -5925.0
GLYATL3 -1082.0 -10576.0
SLC16A1 -5850.5 -9502.5
SLC22A7 -3262.0 -5817.5
SLCO2B1 -7687.5 -2076.5
UGT1A1 2477.0 380.5
UGT1A3 3423.5 1063.5
UGT1A4 3436.5 1557.5
UGT1A5 3379.5 1297.5
UGT1A6 3464.5 -412.5
UGT1A7 3471.5 -612.5
UGT1A8 3465.5 -1075.5
UGT1A9 3446.5 -797.5
UGT2B11 0.5 852.5
UGT2B15 -8003.0 1746.5
UGT2B17 -3883.0 -1230.0
UGT2B4 -2059.5 -5237.0
UGT3A1 -1131.5 -10576.0
UGT3A2 -8386.0 -7642.5



Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains
metric value
setSize 20
pMANOVA 0.000439
p.adjustMANOVA 0.00306
s.dist 0.576
s.estill 0.486
s.novakovic 0.309
p.estill 0.00017
p.novakovic 0.0167




Top 20 genes
Gene estill novakovic
HLA-DQB2 3474.5 2373.5
HLA-DQA1 2183.5 976.0

Click HERE to show all gene set members

All member genes
estill novakovic
CD247 -13646.5 -11684.5
CD3D -6008.0 -13143.0
CD3E 964.5 -1129.0
CD3G -1131.5 -9325.0
CD4 -1737.5 -5657.5
CSK -9280.5 -2957.5
HLA-DPA1 3410.5 -621.5
HLA-DPB1 3223.5 -2837.5
HLA-DQA1 2183.5 976.0
HLA-DQA2 3455.5 -1860.0
HLA-DQB1 -12099.5 -10761.0
HLA-DQB2 3474.5 2373.5
HLA-DRA 3388.5 -2246.0
HLA-DRB1 -2272.0 2332.5
HLA-DRB5 1700.0 -1553.0
LCK -5144.0 -6604.5
PAG1 2084.5 -9505.5
PTPN22 1084.0 -3583.5
PTPRC -1509.0 -5848.0
PTPRJ -5194.5 -6576.5



Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade
metric value
setSize 16
pMANOVA 0.00253
p.adjustMANOVA 0.0116
s.dist 0.573
s.estill -0.337
s.novakovic -0.463
p.estill 0.0196
p.novakovic 0.00134




Top 20 genes
Gene estill novakovic
FRAT1 -14831.5 -16582.5
PPP2CA -15588.0 -13417.5
PPP2R5D -14344.5 -13692.5
CSNK1A1 -12855.5 -14817.0
APC -11101.5 -16901.5
FRAT2 -14044.5 -11187.0
CTNNB1 -13317.5 -11273.0
PPP2R1A -6711.5 -15404.5
GSK3B -8437.0 -11714.5
PPP2R5E -6969.5 -13839.0
PPP2R5A -14965.5 -6366.0
PPP2R1B -8104.0 -11495.5
AXIN1 -8086.5 -9790.5
PPP2R5C -4110.5 -16390.5
PPP2R5B -3383.5 -12382.5

Click HERE to show all gene set members

All member genes
estill novakovic
APC -11101.5 -16901.5
AXIN1 -8086.5 -9790.5
CSNK1A1 -12855.5 -14817.0
CTNNB1 -13317.5 -11273.0
FRAT1 -14831.5 -16582.5
FRAT2 -14044.5 -11187.0
GSK3B -8437.0 -11714.5
PPP2CA -15588.0 -13417.5
PPP2CB -697.5 0.5
PPP2R1A -6711.5 -15404.5
PPP2R1B -8104.0 -11495.5
PPP2R5A -14965.5 -6366.0
PPP2R5B -3383.5 -12382.5
PPP2R5C -4110.5 -16390.5
PPP2R5D -14344.5 -13692.5
PPP2R5E -6969.5 -13839.0



Butyrophilin (BTN) family interactions

Butyrophilin (BTN) family interactions
metric value
setSize 12
pMANOVA 0.00703
p.adjustMANOVA 0.0251
s.dist 0.571
s.estill 0.522
s.novakovic 0.232
p.estill 0.00173
p.novakovic 0.165




Top 20 genes
Gene estill novakovic
BTN3A3 2986.0 1314
BTNL8 0.5 685

Click HERE to show all gene set members

All member genes
estill novakovic
BTN1A1 -4603.0 -9325.0
BTN2A1 -3706.0 -11226.0
BTN2A2 -1264.0 380.5
BTN3A1 2741.5 -589.0
BTN3A2 2621.0 -1681.0
BTN3A3 2986.0 1314.0
BTNL2 3479.5 -14295.5
BTNL8 0.5 685.0
BTNL9 -13373.5 -5762.0
CD209 -3262.0 -3992.0
PPL -4370.5 -10540.0
XDH 3323.0 -8336.0



RUNX2 regulates bone development

RUNX2 regulates bone development
metric value
setSize 29
pMANOVA 3e-05
p.adjustMANOVA 0.000348
s.dist 0.567
s.estill -0.367
s.novakovic -0.432
p.estill 0.000622
p.novakovic 5.66e-05




Top 20 genes
Gene estill novakovic
HDAC4 -16429.5 -17028.5
SATB2 -14372.0 -17453.5
MAF -16000.5 -15615.0
HES1 -14758.5 -15707.0
SMAD4 -14044.5 -15637.0
HEY1 -12920.5 -15776.5
RB1 -15270.5 -12913.5
RUNX2 -13635.5 -14415.5
CBFB -10799.0 -15615.0
HDAC3 -11168.5 -14620.0
COL1A1 -11660.5 -13731.5
HEY2 -14425.0 -10856.0
IHH -15201.5 -10088.0
SMAD6 -8991.5 -16436.5
SMAD1 -11178.0 -10905.5
GLI3 -6343.5 -17335.5
YAP1 -13658.0 -7362.5
SRC -13868.5 -6103.5
ZNF521 -4811.5 -14512.5
MAPK1 -8620.0 -7992.0

Click HERE to show all gene set members

All member genes
estill novakovic
ABL1 -1357.5 -6989.5
BGLAP -12584.5 -5319.0
CBFB -10799.0 -15615.0
COL1A1 -11660.5 -13731.5
GLI2 -691.5 -1326.5
GLI3 -6343.5 -17335.5
HDAC3 -11168.5 -14620.0
HDAC4 -16429.5 -17028.5
HES1 -14758.5 -15707.0
HEY1 -12920.5 -15776.5
HEY2 -14425.0 -10856.0
IHH -15201.5 -10088.0
MAF -16000.5 -15615.0
MAPK1 -8620.0 -7992.0
MAPK3 -10450.5 -1968.5
RB1 -15270.5 -12913.5
RBM14 -3578.5 -14853.0
RUNX2 -13635.5 -14415.5
SATB2 -14372.0 -17453.5
SMAD1 -11178.0 -10905.5
SMAD4 -14044.5 -15637.0
SMAD6 -8991.5 -16436.5
SP7 -8003.0 -6985.0
SRC -13868.5 -6103.5
UCMA -7328.5 -4394.5
WWTR1 -1436.5 -16862.5
YAP1 -13658.0 -7362.5
YES1 -608.0 -16019.0
ZNF521 -4811.5 -14512.5



Chemokine receptors bind chemokines

Chemokine receptors bind chemokines
metric value
setSize 52
pMANOVA 8.82e-09
p.adjustMANOVA 2.73e-07
s.dist 0.566
s.estill 0.378
s.novakovic 0.422
p.estill 2.47e-06
p.novakovic 1.41e-07




Top 20 genes
Gene estill novakovic
CCR1 1575.0 1342.5
CCR8 2134.0 0.5
CCR2 0.5 1766.5
CCL13 1753.0 0.5
CCL3 1575.0 0.5
XCL2 854.0 0.5
CCL21 0.5 541.0
CCL3L1 0.5 0.5

Click HERE to show all gene set members

All member genes
estill novakovic
CCL1 -4266.5 2110.0
CCL11 3196.0 -589.0
CCL13 1753.0 0.5
CCL16 -8838.5 -1561.0
CCL17 -2288.0 -2290.0
CCL19 -1082.0 -3805.5
CCL2 1030.5 -3213.5
CCL20 0.5 -6414.0
CCL21 0.5 541.0
CCL22 -8838.5 -425.0
CCL25 -1807.0 1881.0
CCL27 -5708.5 1834.5
CCL28 -6193.0 -543.5
CCL3 1575.0 0.5
CCL3L1 0.5 0.5
CCL4 854.0 -1955.5
CCL5 -3883.0 -3028.0
CCL7 1960.0 -3457.5
CCR1 1575.0 1342.5
CCR10 -11768.0 -7577.0
CCR2 0.5 1766.5
CCR3 2490.0 -4394.5
CCR4 688.0 -1129.0
CCR5 1419.0 -6631.0
CCR6 2150.0 -2043.5
CCR7 -6193.0 -7394.5
CCR8 2134.0 0.5
CCR9 3255.5 -5404.0
CCRL2 -13109.0 -6922.5
CX3CL1 -15139.0 -556.5
CX3CR1 -4689.0 362.5
CXCL1 -3178.5 -12810.5
CXCL10 0.5 -686.0
CXCL11 -3883.0 -589.0
CXCL12 -9800.5 -14106.5
CXCL13 2324.0 -6953.0
CXCL16 -10032.0 -6868.0
CXCL2 -5329.5 -10203.5
CXCL3 -9845.5 -13143.0
CXCL5 -3883.0 -9976.0
CXCL6 -4266.5 -11187.0
CXCL9 0.5 -3457.5
CXCR1 -1420.5 2355.0
CXCR2 -4458.5 -536.0
CXCR4 -13544.5 -12831.5
CXCR5 -4514.5 -4955.0
CXCR6 3365.5 -6615.0
PF4 -2196.5 1631.0
PPBP -2059.5 -3805.5
XCL1 0.5 -2900.0
XCL2 854.0 0.5
XCR1 -657.0 645.0



Acetylcholine Neurotransmitter Release Cycle

Acetylcholine Neurotransmitter Release Cycle
metric value
setSize 16
pMANOVA 0.00328
p.adjustMANOVA 0.0139
s.dist 0.564
s.estill -0.44
s.novakovic -0.352
p.estill 0.0023
p.novakovic 0.0147




Top 20 genes
Gene estill novakovic
CPLX1 -16219.5 -16469.5
PPFIA2 -14672.0 -16927.5
RIMS1 -14761.5 -16799.5
CHAT -15789.5 -14962.5
PPFIA3 -14896.5 -11712.0
SNAP25 -13942.0 -9428.5
SLC18A3 -12483.5 -10241.5
SYT1 -6994.0 -16913.5
VAMP2 -13608.5 -7550.0
STX1A -15554.0 -6065.0
UNC13B -6759.0 -12277.5
PPFIA4 -5935.5 -12175.5
SLC5A7 -6071.5 -8084.0
PPFIA1 -3001.0 -12196.5
RAB3A -10390.5 -2653.0
STXBP1 -2932.5 -3126.5

Click HERE to show all gene set members

All member genes
estill novakovic
CHAT -15789.5 -14962.5
CPLX1 -16219.5 -16469.5
PPFIA1 -3001.0 -12196.5
PPFIA2 -14672.0 -16927.5
PPFIA3 -14896.5 -11712.0
PPFIA4 -5935.5 -12175.5
RAB3A -10390.5 -2653.0
RIMS1 -14761.5 -16799.5
SLC18A3 -12483.5 -10241.5
SLC5A7 -6071.5 -8084.0
SNAP25 -13942.0 -9428.5
STX1A -15554.0 -6065.0
STXBP1 -2932.5 -3126.5
SYT1 -6994.0 -16913.5
UNC13B -6759.0 -12277.5
VAMP2 -13608.5 -7550.0



Hormone ligand-binding receptors

Hormone ligand-binding receptors
metric value
setSize 12
pMANOVA 0.0026
p.adjustMANOVA 0.0118
s.dist 0.561
s.estill 0.558
s.novakovic 0.0638
p.estill 0.000821
p.novakovic 0.702




Top 20 genes
Gene estill novakovic

Click HERE to show all gene set members

All member genes
estill novakovic
CGA -2059.5 -3457.5
FSHB -1509.0 -2412.0
FSHR -3883.0 -2086.0
GNRH1 854.0 -6326.0
GNRH2 -1717.5 -8712.0
GNRHR2 -2950.0 -13958.5
GPHA2 -3262.0 -4394.5
GPHB5 3196.0 -4105.5
LHB -1509.0 -6131.5
LHCGR 2838.0 -13259.5
TSHB 0.5 -9325.0
TSHR -1192.0 -9281.5



RUNX2 regulates osteoblast differentiation

RUNX2 regulates osteoblast differentiation
metric value
setSize 22
pMANOVA 0.000473
p.adjustMANOVA 0.00322
s.dist 0.559
s.estill -0.371
s.novakovic -0.418
p.estill 0.00259
p.novakovic 0.00069




Top 20 genes
Gene estill novakovic
SATB2 -14372.0 -17453.5
MAF -16000.5 -15615.0
HES1 -14758.5 -15707.0
HEY1 -12920.5 -15776.5
RB1 -15270.5 -12913.5
RUNX2 -13635.5 -14415.5
CBFB -10799.0 -15615.0
HDAC3 -11168.5 -14620.0
COL1A1 -11660.5 -13731.5
HEY2 -14425.0 -10856.0
GLI3 -6343.5 -17335.5
YAP1 -13658.0 -7362.5
SRC -13868.5 -6103.5
ZNF521 -4811.5 -14512.5
MAPK1 -8620.0 -7992.0
BGLAP -12584.5 -5319.0
SP7 -8003.0 -6985.0
UCMA -7328.5 -4394.5
WWTR1 -1436.5 -16862.5
MAPK3 -10450.5 -1968.5

Click HERE to show all gene set members

All member genes
estill novakovic
ABL1 -1357.5 -6989.5
BGLAP -12584.5 -5319.0
CBFB -10799.0 -15615.0
COL1A1 -11660.5 -13731.5
GLI3 -6343.5 -17335.5
HDAC3 -11168.5 -14620.0
HES1 -14758.5 -15707.0
HEY1 -12920.5 -15776.5
HEY2 -14425.0 -10856.0
MAF -16000.5 -15615.0
MAPK1 -8620.0 -7992.0
MAPK3 -10450.5 -1968.5
RB1 -15270.5 -12913.5
RUNX2 -13635.5 -14415.5
SATB2 -14372.0 -17453.5
SP7 -8003.0 -6985.0
SRC -13868.5 -6103.5
UCMA -7328.5 -4394.5
WWTR1 -1436.5 -16862.5
YAP1 -13658.0 -7362.5
YES1 -608.0 -16019.0
ZNF521 -4811.5 -14512.5



Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Negative regulation of TCF-dependent signaling by WNT ligand antagonists
metric value
setSize 15
pMANOVA 0.00234
p.adjustMANOVA 0.011
s.dist 0.55
s.estill -0.519
s.novakovic -0.184
p.estill 0.000501
p.novakovic 0.218




Top 20 genes
Gene estill novakovic
SFRP2 -14377.5 -14881.5
KREMEN1 -13716.0 -15557.5
LRP6 -12280.5 -14248.0
KREMEN2 -8912.5 -15994.0
WIF1 -8770.0 -13369.5
WNT4 -14756.0 -7862.0
DKK1 -14198.0 -7972.5
WNT3A -13143.5 -8587.0
WNT5A -6631.5 -16035.5
SOST -11768.0 -7550.0
SFRP1 -14860.0 -5339.5
DKK2 -11218.5 -4410.5
LRP5 -11940.5 -4026.5
WNT9A -15616.5 -1329.5
DKK4 -2710.0 -4138.0

Click HERE to show all gene set members

All member genes
estill novakovic
DKK1 -14198.0 -7972.5
DKK2 -11218.5 -4410.5
DKK4 -2710.0 -4138.0
KREMEN1 -13716.0 -15557.5
KREMEN2 -8912.5 -15994.0
LRP5 -11940.5 -4026.5
LRP6 -12280.5 -14248.0
SFRP1 -14860.0 -5339.5
SFRP2 -14377.5 -14881.5
SOST -11768.0 -7550.0
WIF1 -8770.0 -13369.5
WNT3A -13143.5 -8587.0
WNT4 -14756.0 -7862.0
WNT5A -6631.5 -16035.5
WNT9A -15616.5 -1329.5



POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
metric value
setSize 10
pMANOVA 0.0348
p.adjustMANOVA 0.0783
s.dist 0.549
s.estill -0.367
s.novakovic -0.409
p.estill 0.0447
p.novakovic 0.0252




Top 20 genes
Gene estill novakovic
GSC -15909.5 -17016.5
CDX2 -14224.5 -15226.5
TSC22D1 -12868.0 -15229.5
SOX2 -13262.0 -12944.0
EOMES -11492.5 -13208.5
GATA6 -9662.5 -15631.5
HHEX -15796.5 -8103.5
DKK1 -14198.0 -7972.5

Click HERE to show all gene set members

All member genes
estill novakovic
CDX2 -14224.5 -15226.5
DKK1 -14198.0 -7972.5
EOMES -11492.5 -13208.5
GATA6 -9662.5 -15631.5
GSC -15909.5 -17016.5
HHEX -15796.5 -8103.5
NANOG 3065.5 -5319.0
POU5F1 2918.5 -5977.5
SOX2 -13262.0 -12944.0
TSC22D1 -12868.0 -15229.5



Creation of C4 and C2 activators

Creation of C4 and C2 activators
metric value
setSize 14
pMANOVA 0.00806
p.adjustMANOVA 0.0279
s.dist 0.549
s.estill 0.319
s.novakovic 0.447
p.estill 0.0388
p.novakovic 0.00379




Top 20 genes
Gene estill novakovic
C1S 2472 521.5
FCN3 688 768.5

Click HERE to show all gene set members

All member genes
estill novakovic
C1QA -8486.5 -951.0
C1QB -9079.5 -4897.0
C1QC -13805.5 -1177.0
C1R 1514.5 -5309.5
C1S 2472.0 521.5
COLEC10 1960.0 -5404.0
COLEC11 -15745.5 2042.5
CRP 3429.5 -11226.0
FCN1 -5708.5 -1438.5
FCN2 -6358.0 -2975.0
FCN3 688.0 768.5
MASP1 3478.0 -8486.0
MASP2 -3178.5 -2368.5
MBL2 2442.0 -3028.0



Formation of the cornified envelope

Formation of the cornified envelope
metric value
setSize 68
pMANOVA 2.11e-10
p.adjustMANOVA 8.2e-09
s.dist 0.543
s.estill 0.364
s.novakovic 0.403
p.estill 2.05e-07
p.novakovic 9.21e-09




Top 20 genes
Gene estill novakovic
SPRR2B 2621.0 1987.0
SPRR2D 2986.0 1585.5
LCE6A 3065.5 1072.5
SPRR2E 1960.0 1419.0
LCE2B 2324.0 1001.5
LELP1 1325.5 1700.0
LCE1A 854.0 1585.5
SPRR3 964.5 1288.5
LIPJ 2621.0 470.0
LCE4A 2324.0 0.5
PI3 0.5 1923.5
SPRR2G 0.5 1527.0

Click HERE to show all gene set members

All member genes
estill novakovic
CAPN1 -9943.0 -17243.0
CAPNS1 -3135.0 -5608.0
CASP14 3196.0 -328.0
CDSN -12147.0 -2338.5
CELA2A 854.0 -2461.0
CSTA -2059.5 2238.5
DSC1 1960.0 -8277.5
DSC2 -8838.5 -14362.5
DSC3 -14623.0 -16812.5
DSG1 0.5 -7167.5
DSG2 -6881.5 408.0
DSG3 -2059.5 -1987.5
DSP -13137.0 -13626.5
EVPL -14219.5 -4797.5
FLG -2824.0 -623.0
FURIN -12844.0 -14078.0
IVL -1264.0 -12098.0
JUP -11101.5 -5614.5
KLK12 -4828.5 518.5
KLK13 -2226.5 -7609.0
KLK14 -4266.5 0.5
KLK5 1419.0 -3588.0
KLK8 -14044.5 -3653.0
LCE1A 854.0 1585.5
LCE1B 854.0 -3805.5
LCE1C 1575.0 -686.0
LCE1D 0.5 -818.0
LCE1E -3262.0 1669.5
LCE1F -5708.5 1142.5
LCE2A 1419.0 -1481.5
LCE2B 2324.0 1001.5
LCE2C -1509.0 -5237.0
LCE2D -2059.5 -686.0
LCE3A -4548.5 1923.5
LCE3D 1960.0 -506.5
LCE3E 854.0 -686.0
LCE4A 2324.0 0.5
LCE5A -5708.5 -1539.5
LCE6A 3065.5 1072.5
LELP1 1325.5 1700.0
LIPJ 2621.0 470.0
LIPK 2621.0 -5571.0
LIPM 0.5 -8277.5
PCSK6 -2320.5 -9963.5
PERP -4134.5 -14523.0
PI3 0.5 1923.5
PKP1 -9566.0 -13849.5
PKP2 -9845.5 363.5
PKP3 -7426.0 -7587.0
PKP4 -5783.0 -11579.5
PPL -4370.5 -10540.0
PRSS8 -9145.5 -476.5
RPTN 854.0 -4588.0
SPINK5 -3883.0 -12713.0
SPINK9 0.5 -3457.5
SPRR1A 2741.5 -374.0
SPRR1B -1082.0 1142.5
SPRR2A 1575.0 -2137.0
SPRR2B 2621.0 1987.0
SPRR2D 2986.0 1585.5
SPRR2E 1960.0 1419.0
SPRR2F -2059.5 -996.5
SPRR2G 0.5 1527.0
SPRR3 964.5 1288.5
ST14 -5770.5 -910.5
TCHH 1708.5 -3954.5
TGM1 -10032.0 1337.0
TGM5 -1208.5 -1066.5



Digestion

Digestion
metric value
setSize 19
pMANOVA 0.002
p.adjustMANOVA 0.00988
s.dist 0.543
s.estill 0.38
s.novakovic 0.388
p.estill 0.00413
p.novakovic 0.00344




Top 20 genes
Gene estill novakovic
AMY1A 0.5 1419
AMY1B 0.5 1419
AMY1C 0.5 1419

Click HERE to show all gene set members

All member genes
estill novakovic
ALPI -14502.5 -5413.5
AMY1A 0.5 1419.0
AMY1B 0.5 1419.0
AMY1C 0.5 1419.0
AMY2B -7328.5 -5817.5
CEL -5101.0 0.5
CHIA 854.0 -6326.0
CHIT1 2078.0 -1932.0
CLPS -4548.5 -2191.5
GUCA2A -3178.5 -3291.5
GUCA2B -11117.0 -2007.5
GUCY2C -2444.5 -530.0
LCT -1321.5 -2064.5
LIPF 0.5 -6326.0
MGAM 3294.0 -10929.5
PNLIP 1960.0 -860.0
PNLIPRP1 3376.0 -11226.0
PNLIPRP2 -992.0 -8070.5
TREH -12421.5 -8118.0



A tetrasaccharide linker sequence is required for GAG synthesis

A tetrasaccharide linker sequence is required for GAG synthesis
metric value
setSize 23
pMANOVA 0.000107
p.adjustMANOVA 0.000977
s.dist 0.542
s.estill -0.515
s.novakovic -0.17
p.estill 1.92e-05
p.novakovic 0.158




Top 20 genes
Gene estill novakovic
GPC5 -15928.5 -16106.5
VCAN -15201.5 -16032.5
SDC3 -14325.0 -16259.5
AGRN -16378.5 -13627.5
SDC1 -15680.0 -12442.5
GPC1 -15708.5 -12289.0
XYLT2 -14400.0 -10700.5
BCAN -13049.5 -11695.5
SDC2 -8031.0 -17012.0
GPC2 -12467.0 -10950.5
NCAN -15371.0 -8677.5
HSPG2 -12862.5 -9841.5
B4GALT7 -13991.0 -8388.0
B3GAT3 -14044.5 -7304.5
B3GAT2 -8264.5 -9447.5
GPC6 -7655.5 -10194.5
CSPG5 -9008.5 -7373.0
CSPG4 -16269.0 -3577.5
SDC4 -7505.0 -4535.5
B3GALT6 -4426.0 -2805.5

Click HERE to show all gene set members

All member genes
estill novakovic
AGRN -16378.5 -13627.5
B3GALT6 -4426.0 -2805.5
B3GAT1 -10551.5 2002.5
B3GAT2 -8264.5 -9447.5
B3GAT3 -14044.5 -7304.5
B4GALT7 -13991.0 -8388.0
BCAN -13049.5 -11695.5
CSPG4 -16269.0 -3577.5
CSPG5 -9008.5 -7373.0
DCN -2059.5 -3204.5
GPC1 -15708.5 -12289.0
GPC2 -12467.0 -10950.5
GPC5 -15928.5 -16106.5
GPC6 -7655.5 -10194.5
HSPG2 -12862.5 -9841.5
NCAN -15371.0 -8677.5
SDC1 -15680.0 -12442.5
SDC2 -8031.0 -17012.0
SDC3 -14325.0 -16259.5
SDC4 -7505.0 -4535.5
VCAN -15201.5 -16032.5
XYLT1 -3996.5 -3106.5
XYLT2 -14400.0 -10700.5



Regulation of commissural axon pathfinding by SLIT and ROBO

Regulation of commissural axon pathfinding by SLIT and ROBO
metric value
setSize 10
pMANOVA 0.0297
p.adjustMANOVA 0.0704
s.dist 0.542
s.estill -0.472
s.novakovic -0.265
p.estill 0.00967
p.novakovic 0.147




Top 20 genes
Gene estill novakovic
ROBO3 -15863.5 -14399.0
ROBO1 -13529.5 -16083.5
NTN1 -15687.5 -11012.5
NELL2 -10910.5 -15442.5
SLIT2 -12655.0 -11248.0
SRC -13868.5 -6103.5
DCC -15445.0 -3631.5
SLIT3 -2964.5 -16457.5
SLIT1 -13542.5 -549.5

Click HERE to show all gene set members

All member genes
estill novakovic
DCC -15445.0 -3631.5
NELL2 -10910.5 -15442.5
NTN1 -15687.5 -11012.5
ROBO1 -13529.5 -16083.5
ROBO2 2478.5 -7363.5
ROBO3 -15863.5 -14399.0
SLIT1 -13542.5 -549.5
SLIT2 -12655.0 -11248.0
SLIT3 -2964.5 -16457.5
SRC -13868.5 -6103.5



Constitutive Signaling by NOTCH1 HD Domain Mutants

Constitutive Signaling by NOTCH1 HD Domain Mutants
metric value
setSize 14
pMANOVA 0.0104
p.adjustMANOVA 0.0333
s.dist 0.541
s.estill -0.403
s.novakovic -0.361
p.estill 0.00902
p.novakovic 0.0192




Top 20 genes
Gene estill novakovic
JAG2 -15196.5 -16196.0
MIB2 -16135.5 -14496.5
JAG1 -13137.0 -15261.5
NEURL1B -12314.5 -14418.0
ADAM17 -8722.5 -16793.5
DLL1 -7191.5 -16815.5
NOTCH1 -14218.5 -7343.5
MIB1 -8003.0 -10174.0
ADAM10 -4458.5 -15909.0
DLL4 -4076.5 -14394.5
UBA52 -8209.5 -6075.0
UBB -10521.5 -4345.0
RPS27A -12747.0 -2534.5
UBC -12147.0 -1923.5

Click HERE to show all gene set members

All member genes
estill novakovic
ADAM10 -4458.5 -15909.0
ADAM17 -8722.5 -16793.5
DLL1 -7191.5 -16815.5
DLL4 -4076.5 -14394.5
JAG1 -13137.0 -15261.5
JAG2 -15196.5 -16196.0
MIB1 -8003.0 -10174.0
MIB2 -16135.5 -14496.5
NEURL1B -12314.5 -14418.0
NOTCH1 -14218.5 -7343.5
RPS27A -12747.0 -2534.5
UBA52 -8209.5 -6075.0
UBB -10521.5 -4345.0
UBC -12147.0 -1923.5



Signaling by NOTCH1 HD Domain Mutants in Cancer

Signaling by NOTCH1 HD Domain Mutants in Cancer
metric value
setSize 14
pMANOVA 0.0104
p.adjustMANOVA 0.0333
s.dist 0.541
s.estill -0.403
s.novakovic -0.361
p.estill 0.00902
p.novakovic 0.0192




Top 20 genes
Gene estill novakovic
JAG2 -15196.5 -16196.0
MIB2 -16135.5 -14496.5
JAG1 -13137.0 -15261.5
NEURL1B -12314.5 -14418.0
ADAM17 -8722.5 -16793.5
DLL1 -7191.5 -16815.5
NOTCH1 -14218.5 -7343.5
MIB1 -8003.0 -10174.0
ADAM10 -4458.5 -15909.0
DLL4 -4076.5 -14394.5
UBA52 -8209.5 -6075.0
UBB -10521.5 -4345.0
RPS27A -12747.0 -2534.5
UBC -12147.0 -1923.5

Click HERE to show all gene set members

All member genes
estill novakovic
ADAM10 -4458.5 -15909.0
ADAM17 -8722.5 -16793.5
DLL1 -7191.5 -16815.5
DLL4 -4076.5 -14394.5
JAG1 -13137.0 -15261.5
JAG2 -15196.5 -16196.0
MIB1 -8003.0 -10174.0
MIB2 -16135.5 -14496.5
NEURL1B -12314.5 -14418.0
NOTCH1 -14218.5 -7343.5
RPS27A -12747.0 -2534.5
UBA52 -8209.5 -6075.0
UBB -10521.5 -4345.0
UBC -12147.0 -1923.5



Scavenging of heme from plasma

Scavenging of heme from plasma
metric value
setSize 11
pMANOVA 0.0293
p.adjustMANOVA 0.0697
s.dist 0.537
s.estill 0.394
s.novakovic 0.365
p.estill 0.0237
p.novakovic 0.0359




Top 20 genes
Gene estill novakovic
APOL1 2218.5 573.5

Click HERE to show all gene set members

All member genes
estill novakovic
ALB -2059.5 -7337.5
AMBP 1575.0 -358.5
APOA1 -7687.5 -3303.0
APOL1 2218.5 573.5
CD163 1960.0 -5878.5
HBA1 -5101.0 -7642.5
HBB -2059.5 -4677.5
HP -3883.0 -7434.5
HPR 1753.0 -318.5
HPX 964.5 -1148.5
LRP1 -15911.5 -5917.5



Ethanol oxidation

Ethanol oxidation
metric value
setSize 11
pMANOVA 0.0232
p.adjustMANOVA 0.059
s.dist 0.537
s.estill 0.271
s.novakovic 0.463
p.estill 0.119
p.novakovic 0.00779




Top 20 genes
Gene estill novakovic
ADH7 0.5 1923.5
ALDH1A1 0.5 1857.0
ADH1A 0.5 0.5

Click HERE to show all gene set members

All member genes
estill novakovic
ACSS1 -4365.0 -9661.5
ACSS2 -9079.5 -9989.0
ADH1A 0.5 0.5
ADH1B -2059.5 -686.0
ADH1C 0.5 -2900.0
ADH5 -7505.0 -2852.5
ADH6 0.5 -5817.5
ADH7 0.5 1923.5
ALDH1A1 0.5 1857.0
ALDH1B1 -11396.5 -2577.0
ALDH2 -7259.5 -1995.0



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      parallel  stats4    stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] dplyr_1.0.9                                        
##  [7] echarts4r_0.4.3                                    
##  [8] mitch_1.8.0                                        
##  [9] ENmix_1.32.0                                       
## [10] doParallel_1.0.17                                  
## [11] qqman_0.1.8                                        
## [12] RCircos_1.2.2                                      
## [13] beeswarm_0.4.0                                     
## [14] forestplot_2.0.1                                   
## [15] checkmate_2.1.0                                    
## [16] magrittr_2.0.3                                     
## [17] reshape2_1.4.4                                     
## [18] gplots_3.1.3                                       
## [19] eulerr_6.1.1                                       
## [20] GEOquery_2.64.2                                    
## [21] RColorBrewer_1.1-3                                 
## [22] IlluminaHumanMethylation450kmanifest_0.4.0         
## [23] topconfects_1.12.0                                 
## [24] DMRcatedata_2.14.0                                 
## [25] ExperimentHub_2.4.0                                
## [26] AnnotationHub_3.4.0                                
## [27] BiocFileCache_2.4.0                                
## [28] dbplyr_2.1.1                                       
## [29] DMRcate_2.10.0                                     
## [30] limma_3.52.1                                       
## [31] missMethyl_1.30.0                                  
## [32] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [33] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [34] minfi_1.42.0                                       
## [35] bumphunter_1.38.0                                  
## [36] locfit_1.5-9.5                                     
## [37] iterators_1.0.14                                   
## [38] foreach_1.5.2                                      
## [39] Biostrings_2.64.0                                  
## [40] XVector_0.36.0                                     
## [41] SummarizedExperiment_1.26.1                        
## [42] Biobase_2.56.0                                     
## [43] MatrixGenerics_1.8.0                               
## [44] matrixStats_0.62.0                                 
## [45] GenomicRanges_1.48.0                               
## [46] GenomeInfoDb_1.32.2                                
## [47] IRanges_2.30.0                                     
## [48] S4Vectors_0.34.0                                   
## [49] BiocGenerics_0.42.0                                
## [50] R.utils_2.11.0                                     
## [51] R.oo_1.24.0                                        
## [52] R.methodsS3_1.8.1                                  
## [53] plyr_1.8.7                                         
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    xml2_1.3.3                   
##  [19] httpuv_1.6.5                  assertthat_0.2.1             
##  [21] xfun_0.31                     hms_1.1.1                    
##  [23] jquerylib_0.1.4               evaluate_0.15                
##  [25] promises_1.2.0.1              fansi_1.0.3                  
##  [27] restfulr_0.0.13               scrime_1.3.5                 
##  [29] progress_1.2.2                caTools_1.18.2               
##  [31] readxl_1.4.0                  DBI_1.1.2                    
##  [33] geneplotter_1.74.0            htmlwidgets_1.5.4            
##  [35] reshape_0.8.9                 purrr_0.3.4                  
##  [37] ellipsis_0.3.2                backports_1.4.1              
##  [39] permute_0.9-7                 calibrate_1.7.7              
##  [41] annotate_1.74.0               biomaRt_2.52.0               
##  [43] sparseMatrixStats_1.8.0       vctrs_0.4.1                  
##  [45] ensembldb_2.20.1              withr_2.5.0                  
##  [47] cachem_1.0.6                  Gviz_1.40.1                  
##  [49] BSgenome_1.64.0               GenomicAlignments_1.32.0     
##  [51] prettyunits_1.1.1             mclust_5.4.9                 
##  [53] cluster_2.1.3                 RPMM_1.25                    
##  [55] lazyeval_0.2.2                crayon_1.5.1                 
##  [57] genefilter_1.78.0             labeling_0.4.2               
##  [59] edgeR_3.38.1                  pkgconfig_2.0.3              
##  [61] nlme_3.1-157                  ProtGenerics_1.28.0          
##  [63] nnet_7.3-17                   rlang_1.0.2                  
##  [65] lifecycle_1.0.1               filelock_1.0.2               
##  [67] dichromat_2.0-0.1             rprojroot_2.0.3              
##  [69] cellranger_1.1.0              rngtools_1.5.2               
##  [71] base64_2.0                    Matrix_1.4-1                 
##  [73] Rhdf5lib_1.18.2               base64enc_0.1-3              
##  [75] png_0.1-7                     rjson_0.2.21                 
##  [77] bitops_1.0-7                  KernSmooth_2.23-20           
##  [79] rhdf5filters_1.8.0            blob_1.2.3                   
##  [81] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [83] stringr_1.4.0                 nor1mix_1.3-0                
##  [85] readr_2.1.2                   jpeg_0.1-9                   
##  [87] scales_1.2.0                  memoise_2.0.1                
##  [89] zlibbioc_1.42.0               compiler_4.2.0               
##  [91] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [93] Rsamtools_2.12.0              cli_3.3.0                    
##  [95] DSS_2.44.0                    htmlTable_2.4.0              
##  [97] Formula_1.2-4                 MASS_7.3-57                  
##  [99] tidyselect_1.1.2              stringi_1.7.6                
## [101] highr_0.9                     yaml_2.3.5                   
## [103] askpass_1.1                   latticeExtra_0.6-29          
## [105] sass_0.4.1                    VariantAnnotation_1.42.1     
## [107] tools_4.2.0                   rstudioapi_0.13              
## [109] foreign_0.8-82                bsseq_1.32.0                 
## [111] gridExtra_2.3                 farver_2.1.0                 
## [113] digest_0.6.29                 BiocManager_1.30.17          
## [115] shiny_1.7.1                   quadprog_1.5-8               
## [117] Rcpp_1.0.8.3                  siggenes_1.70.0              
## [119] BiocVersion_3.15.2            later_1.3.0                  
## [121] org.Hs.eg.db_3.15.0           httr_1.4.3                   
## [123] AnnotationDbi_1.58.0          biovizBase_1.44.0            
## [125] colorspace_2.0-3              brio_1.1.3                   
## [127] XML_3.99-0.9                  splines_4.2.0                
## [129] statmod_1.4.36                multtest_2.52.0              
## [131] xtable_1.8-4                  jsonlite_1.8.0               
## [133] dynamicTreeCut_1.63-1         testthat_3.1.4               
## [135] R6_2.5.1                      Hmisc_4.7-0                  
## [137] pillar_1.7.0                  htmltools_0.5.2              
## [139] mime_0.12                     glue_1.6.2                   
## [141] fastmap_1.1.0                 BiocParallel_1.30.2          
## [143] interactiveDisplayBase_1.34.0 beanplot_1.3.1               
## [145] codetools_0.2-18              utf8_1.2.2                   
## [147] lattice_0.20-45               bslib_0.3.1                  
## [149] curl_4.3.2                    openssl_2.0.1                
## [151] survival_3.3-1                rmarkdown_2.14               
## [153] desc_1.4.1                    munsell_0.5.0                
## [155] rhdf5_2.40.0                  GenomeInfoDbData_1.2.8       
## [157] HDF5Array_1.24.0              impute_1.70.0                
## [159] gtable_0.3.0

END of report