Mitch Report

date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                metric
## TSC22D1     -9.436620
## EHMT2      -10.903254
## ZNRD1       -6.147915
## NCRNA00171  -6.147915
## RGL2        -5.215929
## CFLAR       -7.577876

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2546
num_genes_in_profile	12012
duplicated_genes_present	0
num_profile_genes_in_sets	5835
num_profile_genes_not_in_sets	6177

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1344
num_genesets_included	1202

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Condensation of Prometaphase Chromosomes	10	2.89e-03	-0.544	0.02100
HDR through MMEJ (alt-NHEJ)	11	2.04e-03	-0.537	0.01810
NOTCH2 Activation and Transmission of Signal to the Nucleus	12	1.40e-03	-0.532	0.01400
p75NTR signals via NF-kB	11	3.89e-03	-0.502	0.02580
VLDLR internalisation and degradation	11	5.70e-03	-0.481	0.03370
SARS-CoV-2 modulates autophagy	11	6.55e-03	-0.473	0.03630
RHO GTPases Activate ROCKs	13	4.08e-03	-0.460	0.02670
RIPK1-mediated regulated necrosis	25	8.38e-05	-0.454	0.00198
Regulation of necroptotic cell death	25	8.38e-05	-0.454	0.00198
Voltage gated Potassium channels	13	5.90e-03	0.441	0.03460
Negative regulation of FLT3	13	6.51e-03	-0.436	0.03630
Signaling by NOTCH2	18	1.44e-03	-0.433	0.01400
Meiotic recombination	19	1.12e-03	-0.432	0.01210
Caspase activation via Death Receptors in the presence of ligand	10	1.81e-02	-0.431	0.07400
Glyoxylate metabolism and glycine degradation	19	1.39e-03	-0.423	0.01400
NOTCH3 Activation and Transmission of Signal to the Nucleus	15	5.19e-03	-0.417	0.03150
CTNNB1 S33 mutants aren’t phosphorylated	13	1.03e-02	-0.411	0.04930
CTNNB1 S37 mutants aren’t phosphorylated	13	1.03e-02	-0.411	0.04930
CTNNB1 S45 mutants aren’t phosphorylated	13	1.03e-02	-0.411	0.04930
CTNNB1 T41 mutants aren’t phosphorylated	13	1.03e-02	-0.411	0.04930
Signaling by CTNNB1 phospho-site mutants	13	1.03e-02	-0.411	0.04930
Signaling by GSK3beta mutants	13	1.03e-02	-0.411	0.04930
Golgi Cisternae Pericentriolar Stack Reorganization	14	7.95e-03	-0.410	0.04170
Defects in vitamin and cofactor metabolism	16	5.94e-03	-0.397	0.03460
APC truncation mutants have impaired AXIN binding	12	2.09e-02	-0.385	0.08090
AXIN missense mutants destabilize the destruction complex	12	2.09e-02	-0.385	0.08090
Signaling by AMER1 mutants	12	2.09e-02	-0.385	0.08090
Signaling by APC mutants	12	2.09e-02	-0.385	0.08090
Signaling by AXIN mutants	12	2.09e-02	-0.385	0.08090
Truncations of AMER1 destabilize the destruction complex	12	2.09e-02	-0.385	0.08090
NRIF signals cell death from the nucleus	14	1.28e-02	-0.384	0.05800
Glycogen storage diseases	10	3.64e-02	-0.382	0.12400
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	27	6.33e-04	-0.380	0.00746
Gap-filling DNA repair synthesis and ligation in GG-NER	23	1.65e-03	-0.379	0.01540
Translesion synthesis by POLK	15	1.20e-02	-0.374	0.05550
Impaired BRCA2 binding to RAD51	32	2.65e-04	-0.372	0.00426
HDR through Single Strand Annealing (SSA)	35	2.48e-04	-0.358	0.00420
Beta-catenin phosphorylation cascade	15	1.66e-02	-0.357	0.06940
Cobalamin (Cbl, vitamin B12) transport and metabolism	11	4.13e-02	-0.355	0.13500
mRNA decay by 3’ to 5’ exoribonuclease	14	2.20e-02	-0.353	0.08410
Glycogen synthesis	11	4.25e-02	-0.353	0.13700
APC/C:Cdc20 mediated degradation of Cyclin B	22	4.81e-03	-0.347	0.02990
Chaperone Mediated Autophagy	12	3.83e-02	-0.345	0.12800
Translation of Structural Proteins	27	1.93e-03	-0.345	0.01740
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	14	2.57e-02	-0.344	0.09420
Signaling by Ligand-Responsive EGFR Variants in Cancer	14	2.57e-02	-0.344	0.09420
Spry regulation of FGF signaling	15	2.17e-02	-0.342	0.08350
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	1.24e-02	-0.340	0.05650
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	15	2.28e-02	-0.339	0.08690
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	37	3.52e-04	-0.339	0.00492

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Condensation of Prometaphase Chromosomes	10	2.89e-03	-5.44e-01	2.10e-02
HDR through MMEJ (alt-NHEJ)	11	2.04e-03	-5.37e-01	1.81e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	12	1.40e-03	-5.32e-01	1.40e-02
p75NTR signals via NF-kB	11	3.89e-03	-5.02e-01	2.58e-02
VLDLR internalisation and degradation	11	5.70e-03	-4.81e-01	3.37e-02
SARS-CoV-2 modulates autophagy	11	6.55e-03	-4.73e-01	3.63e-02
RHO GTPases Activate ROCKs	13	4.08e-03	-4.60e-01	2.67e-02
RIPK1-mediated regulated necrosis	25	8.38e-05	-4.54e-01	1.98e-03
Regulation of necroptotic cell death	25	8.38e-05	-4.54e-01	1.98e-03
Voltage gated Potassium channels	13	5.90e-03	4.41e-01	3.46e-02
Negative regulation of FLT3	13	6.51e-03	-4.36e-01	3.63e-02
Signaling by NOTCH2	18	1.44e-03	-4.33e-01	1.40e-02
Meiotic recombination	19	1.12e-03	-4.32e-01	1.21e-02
Caspase activation via Death Receptors in the presence of ligand	10	1.81e-02	-4.31e-01	7.40e-02
Glyoxylate metabolism and glycine degradation	19	1.39e-03	-4.23e-01	1.40e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus	15	5.19e-03	-4.17e-01	3.15e-02
CTNNB1 S33 mutants aren’t phosphorylated	13	1.03e-02	-4.11e-01	4.93e-02
CTNNB1 S37 mutants aren’t phosphorylated	13	1.03e-02	-4.11e-01	4.93e-02
CTNNB1 S45 mutants aren’t phosphorylated	13	1.03e-02	-4.11e-01	4.93e-02
CTNNB1 T41 mutants aren’t phosphorylated	13	1.03e-02	-4.11e-01	4.93e-02
Signaling by CTNNB1 phospho-site mutants	13	1.03e-02	-4.11e-01	4.93e-02
Signaling by GSK3beta mutants	13	1.03e-02	-4.11e-01	4.93e-02
Golgi Cisternae Pericentriolar Stack Reorganization	14	7.95e-03	-4.10e-01	4.17e-02
Defects in vitamin and cofactor metabolism	16	5.94e-03	-3.97e-01	3.46e-02
APC truncation mutants have impaired AXIN binding	12	2.09e-02	-3.85e-01	8.09e-02
AXIN missense mutants destabilize the destruction complex	12	2.09e-02	-3.85e-01	8.09e-02
Signaling by AMER1 mutants	12	2.09e-02	-3.85e-01	8.09e-02
Signaling by APC mutants	12	2.09e-02	-3.85e-01	8.09e-02
Signaling by AXIN mutants	12	2.09e-02	-3.85e-01	8.09e-02
Truncations of AMER1 destabilize the destruction complex	12	2.09e-02	-3.85e-01	8.09e-02
NRIF signals cell death from the nucleus	14	1.28e-02	-3.84e-01	5.80e-02
Glycogen storage diseases	10	3.64e-02	-3.82e-01	1.24e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	27	6.33e-04	-3.80e-01	7.46e-03
Gap-filling DNA repair synthesis and ligation in GG-NER	23	1.65e-03	-3.79e-01	1.54e-02
Translesion synthesis by POLK	15	1.20e-02	-3.74e-01	5.55e-02
Impaired BRCA2 binding to RAD51	32	2.65e-04	-3.72e-01	4.26e-03
HDR through Single Strand Annealing (SSA)	35	2.48e-04	-3.58e-01	4.20e-03
Beta-catenin phosphorylation cascade	15	1.66e-02	-3.57e-01	6.94e-02
Cobalamin (Cbl, vitamin B12) transport and metabolism	11	4.13e-02	-3.55e-01	1.35e-01
mRNA decay by 3’ to 5’ exoribonuclease	14	2.20e-02	-3.53e-01	8.41e-02
Glycogen synthesis	11	4.25e-02	-3.53e-01	1.37e-01
APC/C:Cdc20 mediated degradation of Cyclin B	22	4.81e-03	-3.47e-01	2.99e-02
Chaperone Mediated Autophagy	12	3.83e-02	-3.45e-01	1.28e-01
Translation of Structural Proteins	27	1.93e-03	-3.45e-01	1.74e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	14	2.57e-02	-3.44e-01	9.42e-02
Signaling by Ligand-Responsive EGFR Variants in Cancer	14	2.57e-02	-3.44e-01	9.42e-02
Spry regulation of FGF signaling	15	2.17e-02	-3.42e-01	8.35e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	1.24e-02	-3.40e-01	5.65e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	15	2.28e-02	-3.39e-01	8.69e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	37	3.52e-04	-3.39e-01	4.92e-03
Diseases of DNA Double-Strand Break Repair	37	3.52e-04	-3.39e-01	4.92e-03
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	11	5.19e-02	-3.38e-01	1.58e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	64	2.87e-06	-3.38e-01	1.64e-04
Amyloid fiber formation	27	2.34e-03	-3.38e-01	2.00e-02
Presynaptic phase of homologous DNA pairing and strand exchange	36	4.82e-04	-3.36e-01	5.97e-03
Sema4D induced cell migration and growth-cone collapse	12	4.39e-02	-3.36e-01	1.39e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	20	9.56e-03	-3.35e-01	4.81e-02
Translesion Synthesis by POLH	17	1.76e-02	-3.32e-01	7.24e-02
Translesion synthesis by REV1	14	3.18e-02	-3.31e-01	1.11e-01
Homologous DNA Pairing and Strand Exchange	39	3.45e-04	-3.31e-01	4.92e-03
Mucopolysaccharidoses	10	6.98e-02	3.31e-01	1.92e-01
Meiosis	42	2.34e-04	-3.28e-01	4.01e-03
EGFR downregulation	20	1.18e-02	-3.25e-01	5.51e-02
Class I peroxisomal membrane protein import	19	1.49e-02	-3.23e-01	6.46e-02
Autodegradation of Cdh1 by Cdh1:APC/C	56	3.75e-05	-3.18e-01	1.45e-03
GAB1 signalosome	10	8.11e-02	3.18e-01	2.12e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	44	2.70e-04	-3.17e-01	4.26e-03
p53-Independent DNA Damage Response	44	2.70e-04	-3.17e-01	4.26e-03
p53-Independent G1/S DNA damage checkpoint	44	2.70e-04	-3.17e-01	4.26e-03
Erythropoietin activates RAS	10	8.31e-02	-3.16e-01	2.15e-01
Recognition of DNA damage by PCNA-containing replication complex	26	5.32e-03	-3.16e-01	3.21e-02
Diseases of mitotic cell cycle	34	1.48e-03	-3.15e-01	1.42e-02
The role of GTSE1 in G2/M progression after G2 checkpoint	52	8.64e-05	-3.15e-01	2.00e-03
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	2.12e-02	-3.14e-01	8.17e-02
Assembly of collagen fibrils and other multimeric structures	14	4.23e-02	3.13e-01	1.37e-01
Pexophagy	11	7.22e-02	-3.13e-01	1.97e-01
APC-Cdc20 mediated degradation of Nek2A	24	8.17e-03	-3.12e-01	4.22e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation	42	4.90e-04	-3.11e-01	6.01e-03
Processing of DNA double-strand break ends	55	6.69e-05	-3.11e-01	1.87e-03
APC/C:Cdc20 mediated degradation of Securin	58	4.68e-05	-3.09e-01	1.52e-03
Ubiquitin-dependent degradation of Cyclin D	44	3.94e-04	-3.09e-01	5.26e-03
PCNA-Dependent Long Patch Base Excision Repair	18	2.36e-02	-3.08e-01	8.89e-02
Striated Muscle Contraction	10	9.24e-02	-3.07e-01	2.34e-01
Apoptotic cleavage of cellular proteins	25	7.84e-03	-3.07e-01	4.15e-02
Autodegradation of the E3 ubiquitin ligase COP1	44	4.31e-04	-3.07e-01	5.49e-03
G2/M DNA damage checkpoint	54	1.11e-04	-3.04e-01	2.24e-03
Initiation of Nuclear Envelope (NE) Reformation	17	3.02e-02	-3.04e-01	1.07e-01
SCF(Skp2)-mediated degradation of p27/p21	52	1.66e-04	-3.02e-01	2.98e-03
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	12	7.03e-02	3.02e-01	1.93e-01
SUMOylation of transcription factors	13	6.07e-02	-3.00e-01	1.77e-01
Frs2-mediated activation	11	8.50e-02	-3.00e-01	2.19e-01
Cyclin A/B1/B2 associated events during G2/M transition	22	1.50e-02	-2.99e-01	6.51e-02
Regulation of TP53 Expression and Degradation	34	2.56e-03	-2.99e-01	2.06e-02
Stabilization of p53	49	2.99e-04	-2.99e-01	4.55e-03
STING mediated induction of host immune responses	10	1.03e-01	2.98e-01	2.54e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	66	3.19e-05	-2.96e-01	1.28e-03
Translesion synthesis by POLI	15	4.73e-02	-2.96e-01	1.47e-01
Regulation of TP53 Activity through Phosphorylation	79	5.61e-06	-2.96e-01	2.70e-04
Aberrant regulation of mitotic cell cycle due to RB1 defects	33	3.30e-03	-2.95e-01	2.29e-02
Cyclin D associated events in G1	41	1.07e-03	-2.95e-01	1.17e-02
G1 Phase	41	1.07e-03	-2.95e-01	1.17e-02
RHO GTPases Activate WASPs and WAVEs	29	6.05e-03	-2.94e-01	3.48e-02
Phosphorylation of the APC/C	18	3.06e-02	-2.94e-01	1.08e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	18	3.07e-02	-2.94e-01	1.08e-01
G1/S DNA Damage Checkpoints	58	1.10e-04	-2.94e-01	2.24e-03
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	35	2.65e-03	-2.93e-01	2.06e-02
DNA Double Strand Break Response	36	2.42e-03	-2.92e-01	2.03e-02
CDK-mediated phosphorylation and removal of Cdc6	62	7.12e-05	-2.92e-01	1.87e-03
APC/C:Cdc20 mediated degradation of mitotic proteins	65	4.83e-05	-2.92e-01	1.53e-03
RUNX3 regulates p14-ARF	10	1.10e-01	-2.91e-01	2.67e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	63	6.40e-05	-2.91e-01	1.87e-03
p53-Dependent G1 DNA Damage Response	56	1.65e-04	-2.91e-01	2.98e-03
p53-Dependent G1/S DNA damage checkpoint	56	1.65e-04	-2.91e-01	2.98e-03
HDR through Homologous Recombination (HRR)	60	9.83e-05	-2.91e-01	2.15e-03
Regulation of TP53 Degradation	33	3.99e-03	-2.90e-01	2.62e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	19	3.03e-02	-2.87e-01	1.07e-01
Base Excision Repair	38	2.23e-03	-2.87e-01	1.91e-02
PKA activation	10	1.17e-01	2.87e-01	2.80e-01
APC/C-mediated degradation of cell cycle proteins	77	1.41e-05	-2.86e-01	6.03e-04
Regulation of mitotic cell cycle	77	1.41e-05	-2.86e-01	6.03e-04
Zinc transporters	12	8.60e-02	-2.86e-01	2.20e-01
RHO GTPases activate PAKs	13	7.45e-02	-2.86e-01	2.00e-01
Resolution of Abasic Sites (AP sites)	31	5.97e-03	-2.85e-01	3.46e-02
Signaling by NOTCH3	30	7.03e-03	-2.84e-01	3.86e-02
Miscellaneous transport and binding events	14	6.59e-02	-2.84e-01	1.86e-01
SRP-dependent cotranslational protein targeting to membrane	88	4.28e-06	-2.84e-01	2.34e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	62	1.17e-04	-2.83e-01	2.31e-03
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	5.95e-02	-2.81e-01	1.75e-01
Signaling by FGFR3	26	1.37e-02	-2.79e-01	6.12e-02
Homology Directed Repair	90	5.02e-06	-2.79e-01	2.62e-04
Caspase activation via extrinsic apoptotic signalling pathway	15	6.20e-02	-2.78e-01	1.80e-01
Apoptotic factor-mediated response	16	5.44e-02	-2.78e-01	1.63e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	46	1.19e-03	-2.76e-01	1.27e-02
HDMs demethylate histones	15	6.65e-02	-2.74e-01	1.87e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	57	3.63e-04	-2.73e-01	5.01e-03
Cyclin A:Cdk2-associated events at S phase entry	74	5.26e-05	-2.72e-01	1.62e-03
Regulation of PTEN stability and activity	56	4.38e-04	-2.72e-01	5.49e-03
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	6.08e-02	-2.71e-01	1.77e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	6.08e-02	-2.71e-01	1.77e-01
SCF-beta-TrCP mediated degradation of Emi1	47	1.37e-03	-2.70e-01	1.40e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA	46	1.54e-03	-2.70e-01	1.46e-02
Prefoldin mediated transfer of substrate to CCT/TriC	17	5.43e-02	-2.69e-01	1.63e-01
DNA Damage Recognition in GG-NER	35	5.90e-03	-2.69e-01	3.46e-02
Fanconi Anemia Pathway	31	9.90e-03	-2.68e-01	4.92e-02
Degradation of DVL	48	1.36e-03	-2.67e-01	1.40e-02
Apoptotic execution phase	33	8.08e-03	-2.66e-01	4.20e-02
Senescence-Associated Secretory Phenotype (SASP)	42	2.83e-03	-2.66e-01	2.10e-02
Endosomal/Vacuolar pathway	10	1.46e-01	2.65e-01	3.32e-01
Hh mutants are degraded by ERAD	47	1.65e-03	-2.65e-01	1.54e-02
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	39	4.19e-03	-2.65e-01	2.69e-02
Regulated Necrosis	43	2.66e-03	-2.65e-01	2.06e-02
Regulation of Apoptosis	45	2.15e-03	-2.64e-01	1.87e-02
RNA Polymerase I Transcription Initiation	40	3.87e-03	-2.64e-01	2.58e-02
Cross-presentation of soluble exogenous antigens (endosomes)	38	4.88e-03	-2.64e-01	2.99e-02
Signaling by EGFR in Cancer	16	6.79e-02	-2.64e-01	1.89e-01
Activation of ATR in response to replication stress	36	6.43e-03	-2.62e-01	3.63e-02
Removal of the Flap Intermediate from the C-strand	15	7.92e-02	-2.62e-01	2.09e-01
Gap junction trafficking and regulation	11	1.33e-01	2.62e-01	3.08e-01
Cyclin E associated events during G1/S transition	72	1.31e-04	-2.61e-01	2.49e-03
SARS-CoV-1 Infection	46	2.23e-03	-2.61e-01	1.91e-02
IKK complex recruitment mediated by RIP1	17	6.27e-02	-2.61e-01	1.80e-01
Elevation of cytosolic Ca2+ levels	10	1.56e-01	2.59e-01	3.43e-01
Vpu mediated degradation of CD4	44	2.94e-03	-2.59e-01	2.10e-02
RNA Polymerase I Promoter Clearance	44	2.94e-03	-2.59e-01	2.10e-02
RNA Polymerase I Transcription	44	2.94e-03	-2.59e-01	2.10e-02
mRNA decay by 5’ to 3’ exoribonuclease	15	8.22e-02	-2.59e-01	2.14e-01
Reproduction	48	1.90e-03	-2.59e-01	1.74e-02
SUMOylation of immune response proteins	10	1.56e-01	-2.59e-01	3.43e-01
Regulation of ornithine decarboxylase (ODC)	43	3.31e-03	-2.59e-01	2.29e-02
Degradation of AXIN	47	2.15e-03	-2.59e-01	1.87e-02
Regulation of RAS by GAPs	56	8.16e-04	-2.59e-01	9.26e-03
FLT3 signaling in disease	24	2.88e-02	-2.58e-01	1.03e-01
BBSome-mediated cargo-targeting to cilium	19	5.17e-02	-2.58e-01	1.58e-01
Transport of vitamins, nucleosides, and related molecules	21	4.09e-02	2.58e-01	1.34e-01
Response of Mtb to phagocytosis	20	4.60e-02	-2.58e-01	1.44e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	46	2.54e-03	-2.57e-01	2.06e-02
Potassium Channels	30	1.48e-02	2.57e-01	6.46e-02
Heme biosynthesis	10	1.60e-01	-2.57e-01	3.48e-01
Downregulation of ERBB2:ERBB3 signaling	10	1.60e-01	-2.57e-01	3.48e-01
Methylation	10	1.61e-01	-2.56e-01	3.49e-01
Vif-mediated degradation of APOBEC3G	43	3.78e-03	-2.55e-01	2.56e-02
Removal of the Flap Intermediate	12	1.27e-01	-2.54e-01	2.99e-01
Signaling by FGFR1	28	2.01e-02	-2.54e-01	7.98e-02
Signaling by FGFR4	25	2.81e-02	-2.54e-01	1.01e-01
Leading Strand Synthesis	12	1.28e-01	-2.54e-01	3.00e-01
Polymerase switching	12	1.28e-01	-2.54e-01	3.00e-01
Signaling by NOTCH4	68	3.11e-04	-2.53e-01	4.68e-03
TRAF6 mediated NF-kB activation	19	5.68e-02	-2.52e-01	1.69e-01
G2/M Checkpoints	119	2.23e-06	-2.51e-01	1.34e-04
Asymmetric localization of PCP proteins	51	1.91e-03	-2.51e-01	1.74e-02
PI3K Cascade	19	5.79e-02	2.51e-01	1.72e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	84	6.95e-05	-2.51e-01	1.87e-03
Regulation of APC/C activators between G1/S and early anaphase	70	2.98e-04	-2.50e-01	4.55e-03
Transcription of E2F targets under negative control by DREAM complex	18	6.64e-02	-2.50e-01	1.87e-01
Plasma lipoprotein clearance	24	3.53e-02	-2.48e-01	1.21e-01
Lagging Strand Synthesis	17	7.71e-02	-2.48e-01	2.05e-01
Glycogen metabolism	17	7.74e-02	-2.47e-01	2.05e-01
Degradation of GLI2 by the proteasome	50	2.68e-03	-2.45e-01	2.06e-02
GLI3 is processed to GLI3R by the proteasome	50	2.68e-03	-2.45e-01	2.06e-02
Separation of Sister Chromatids	147	3.34e-07	-2.44e-01	2.86e-05
RMTs methylate histone arginines	25	3.45e-02	-2.44e-01	1.19e-01
Formation of a pool of free 40S subunits	78	1.99e-04	-2.44e-01	3.52e-03
Deadenylation-dependent mRNA decay	52	2.48e-03	-2.43e-01	2.06e-02
Regulation of actin dynamics for phagocytic cup formation	44	5.37e-03	-2.43e-01	3.21e-02
Meiotic synapsis	25	3.59e-02	-2.42e-01	1.22e-01
Degradation of beta-catenin by the destruction complex	68	5.51e-04	-2.42e-01	6.70e-03
DNA Replication Pre-Initiation	90	7.46e-05	-2.42e-01	1.87e-03
Sensory processing of sound by outer hair cells of the cochlea	18	7.57e-02	2.42e-01	2.02e-01
Diseases associated with N-glycosylation of proteins	18	7.58e-02	-2.42e-01	2.02e-01
Association of TriC/CCT with target proteins during biosynthesis	29	2.48e-02	-2.41e-01	9.13e-02
Infection with Mycobacterium tuberculosis	22	5.08e-02	-2.40e-01	1.56e-01
Polo-like kinase mediated events	15	1.07e-01	-2.40e-01	2.61e-01
Defective CFTR causes cystic fibrosis	52	2.71e-03	-2.40e-01	2.06e-02
Degradation of GLI1 by the proteasome	51	3.09e-03	-2.40e-01	2.20e-02
Caspase-mediated cleavage of cytoskeletal proteins	10	1.90e-01	-2.39e-01	3.84e-01
TICAM1, RIP1-mediated IKK complex recruitment	17	8.76e-02	-2.39e-01	2.23e-01
Purine salvage	11	1.70e-01	-2.39e-01	3.60e-01
Hh mutants abrogate ligand secretion	49	3.83e-03	-2.39e-01	2.57e-02
Signaling by Erythropoietin	19	7.17e-02	-2.39e-01	1.96e-01
SUMOylation of ubiquitinylation proteins	37	1.24e-02	-2.38e-01	5.65e-02
RNA Polymerase I Transcription Termination	25	3.97e-02	-2.38e-01	1.31e-01
Mitochondrial tRNA aminoacylation	18	8.10e-02	-2.37e-01	2.12e-01
Assembly of the pre-replicative complex	76	3.51e-04	-2.37e-01	4.92e-03
Oncogene Induced Senescence	30	2.47e-02	-2.37e-01	9.13e-02
DNA Double-Strand Break Repair	117	1.00e-05	-2.37e-01	4.64e-04
Negative regulation of NOTCH4 signaling	48	4.58e-03	-2.37e-01	2.87e-02
Diseases of DNA repair	45	6.10e-03	-2.36e-01	3.49e-02
FCERI mediated MAPK activation	23	5.01e-02	-2.36e-01	1.54e-01
Major pathway of rRNA processing in the nucleolus and cytosol	152	5.54e-07	-2.36e-01	4.44e-05
DNA strand elongation	28	3.08e-02	-2.36e-01	1.08e-01
Negative regulation of FGFR1 signaling	18	8.35e-02	-2.36e-01	2.15e-01
Negative regulation of FGFR2 signaling	18	8.35e-02	-2.36e-01	2.15e-01
Negative regulation of FGFR3 signaling	18	8.35e-02	-2.36e-01	2.15e-01
Negative regulation of FGFR4 signaling	18	8.35e-02	-2.36e-01	2.15e-01
Degradation of the extracellular matrix	35	1.64e-02	2.34e-01	6.87e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	14	1.29e-01	-2.34e-01	3.01e-01
Signaling by Leptin	10	2.00e-01	-2.34e-01	3.95e-01
Regulation of TP53 Activity through Methylation	17	9.53e-02	-2.34e-01	2.40e-01
S Phase	141	1.80e-06	-2.33e-01	1.20e-04
Long-term potentiation	11	1.81e-01	2.33e-01	3.73e-01
Calnexin/calreticulin cycle	23	5.32e-02	-2.33e-01	1.61e-01
Chaperonin-mediated protein folding	57	2.48e-03	-2.32e-01	2.06e-02
Formation of the ternary complex, and subsequently, the 43S complex	40	1.13e-02	-2.32e-01	5.30e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	13	1.49e-01	-2.31e-01	3.37e-01
Ion transport by P-type ATPases	27	3.84e-02	-2.30e-01	1.28e-01
Synthesis of DNA	106	4.36e-05	-2.30e-01	1.52e-03
Ovarian tumor domain proteases	29	3.21e-02	-2.30e-01	1.11e-01
Transcriptional regulation by RUNX3	75	5.84e-04	-2.30e-01	7.01e-03
ERKs are inactivated	11	1.87e-01	-2.29e-01	3.82e-01
RNA Polymerase I Promoter Escape	27	3.91e-02	-2.29e-01	1.30e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	22	6.26e-02	-2.29e-01	1.80e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	22	6.26e-02	-2.29e-01	1.80e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	22	6.26e-02	-2.29e-01	1.80e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	22	6.26e-02	-2.29e-01	1.80e-01
Impaired BRCA2 binding to PALB2	22	6.26e-02	-2.29e-01	1.80e-01
DCC mediated attractive signaling	11	1.90e-01	2.28e-01	3.84e-01
Platelet sensitization by LDL	13	1.54e-01	-2.28e-01	3.42e-01
PKA-mediated phosphorylation of CREB	11	1.91e-01	2.28e-01	3.84e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	12	1.73e-01	-2.27e-01	3.62e-01
L13a-mediated translational silencing of Ceruloplasmin expression	87	2.57e-04	-2.27e-01	4.26e-03
Regulation of RUNX2 expression and activity	57	3.17e-03	-2.26e-01	2.23e-02
RHOBTB1 GTPase cycle	18	9.72e-02	-2.26e-01	2.44e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	1.22e-01	-2.24e-01	2.90e-01
rRNA processing in the nucleus and cytosol	159	1.22e-06	-2.23e-01	9.13e-05
DNA Replication	113	4.37e-05	-2.23e-01	1.52e-03
Cell Cycle Checkpoints	228	7.61e-09	-2.23e-01	1.14e-06
TNFs bind their physiological receptors	10	2.23e-01	2.23e-01	4.23e-01
Peptide chain elongation	69	1.40e-03	-2.22e-01	1.40e-02
Mitotic Anaphase	195	9.14e-08	-2.22e-01	9.53e-06
Constitutive Signaling by EGFRvIII	10	2.23e-01	-2.22e-01	4.23e-01
Signaling by EGFRvIII in Cancer	10	2.23e-01	-2.22e-01	4.23e-01
Deactivation of the beta-catenin transactivating complex	28	4.20e-02	-2.22e-01	1.37e-01
Cytochrome c-mediated apoptotic response	11	2.02e-01	-2.22e-01	3.99e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	41	1.40e-02	-2.22e-01	6.12e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	41	1.40e-02	-2.22e-01	6.12e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	41	1.40e-02	-2.22e-01	6.12e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	41	1.40e-02	-2.22e-01	6.12e-02
Signaling by NOTCH1 in Cancer	41	1.40e-02	-2.22e-01	6.12e-02
Global Genome Nucleotide Excision Repair (GG-NER)	76	8.41e-04	-2.22e-01	9.45e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	88	3.30e-04	-2.22e-01	4.84e-03
Regulation of RUNX3 expression and activity	49	7.32e-03	-2.21e-01	3.95e-02
Switching of origins to a post-replicative state	81	6.28e-04	-2.20e-01	7.46e-03
Signaling by ERBB2 ECD mutants	10	2.29e-01	-2.20e-01	4.28e-01
Mitotic Metaphase and Anaphase	196	1.24e-07	-2.20e-01	1.15e-05
Cleavage of the damaged pyrimidine	14	1.55e-01	-2.20e-01	3.42e-01
Depyrimidination	14	1.55e-01	-2.20e-01	3.42e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	14	1.55e-01	-2.20e-01	3.42e-01
Smooth Muscle Contraction	19	9.79e-02	-2.19e-01	2.45e-01
Mitochondrial iron-sulfur cluster biogenesis	12	1.90e-01	-2.18e-01	3.84e-01
Positive epigenetic regulation of rRNA expression	40	1.71e-02	-2.18e-01	7.10e-02
Mitotic G1 phase and G1/S transition	129	2.01e-05	-2.18e-01	8.35e-04
G0 and Early G1	24	6.58e-02	-2.17e-01	1.86e-01
Dectin-1 mediated noncanonical NF-kB signaling	52	6.83e-03	-2.17e-01	3.76e-02
Complex I biogenesis	43	1.39e-02	-2.17e-01	6.12e-02
Unwinding of DNA	11	2.13e-01	-2.17e-01	4.13e-01
Notch-HLH transcription pathway	21	8.57e-02	-2.17e-01	2.20e-01
RIP-mediated NFkB activation via ZBP1	14	1.62e-01	-2.16e-01	3.51e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	53	6.56e-03	-2.16e-01	3.63e-02
NIK–>noncanonical NF-kB signaling	51	7.71e-03	-2.16e-01	4.10e-02
Metabolism of polyamines	48	9.85e-03	-2.15e-01	4.91e-02
DNA Damage/Telomere Stress Induced Senescence	24	6.80e-02	-2.15e-01	1.89e-01
Translation	238	1.31e-08	-2.15e-01	1.57e-06
Inactivation of APC/C via direct inhibition of the APC/C complex	19	1.05e-01	-2.15e-01	2.58e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	19	1.05e-01	-2.15e-01	2.58e-01
Cellular response to hypoxia	60	4.16e-03	-2.14e-01	2.69e-02
AURKA Activation by TPX2	59	4.54e-03	-2.14e-01	2.86e-02
G1/S Transition	115	7.82e-05	-2.13e-01	1.92e-03
Sema3A PAK dependent Axon repulsion	11	2.21e-01	-2.13e-01	4.21e-01
Transcriptional Regulation by VENTX	30	4.36e-02	-2.13e-01	1.39e-01
Sema4D in semaphorin signaling	15	1.55e-01	-2.12e-01	3.42e-01
Elastic fibre formation	17	1.30e-01	2.12e-01	3.03e-01
Activated NOTCH1 Transmits Signal to the Nucleus	19	1.10e-01	-2.12e-01	2.67e-01
Eukaryotic Translation Termination	72	2.00e-03	-2.11e-01	1.78e-02
Selenocysteine synthesis	70	2.39e-03	-2.10e-01	2.02e-02
Interleukin-6 family signaling	13	1.90e-01	2.10e-01	3.84e-01
Cap-dependent Translation Initiation	95	4.20e-04	-2.10e-01	5.43e-03
Eukaryotic Translation Initiation	95	4.20e-04	-2.10e-01	5.43e-03
TP53 Regulates Transcription of DNA Repair Genes	52	8.98e-03	-2.10e-01	4.55e-02
Viral mRNA Translation	69	2.65e-03	-2.09e-01	2.06e-02
Downregulation of ERBB2 signaling	17	1.35e-01	-2.09e-01	3.12e-01
MAPK6/MAPK4 signaling	69	2.69e-03	-2.09e-01	2.06e-02
Interleukin-10 signaling	13	1.92e-01	2.09e-01	3.85e-01
Branched-chain amino acid catabolism	20	1.08e-01	-2.08e-01	2.63e-01
SUMOylation of SUMOylation proteins	32	4.22e-02	-2.08e-01	1.37e-01
TICAM1-dependent activation of IRF3/IRF7	12	2.14e-01	-2.07e-01	4.13e-01
Negative regulation of MAPK pathway	36	3.20e-02	-2.07e-01	1.11e-01
rRNA processing	164	5.43e-06	-2.06e-01	2.70e-04
Nuclear Pore Complex (NPC) Disassembly	34	3.76e-02	-2.06e-01	1.27e-01
ER-Phagosome pathway	69	3.14e-03	-2.06e-01	2.22e-02
Termination of translesion DNA synthesis	28	5.96e-02	-2.06e-01	1.75e-01
Termination of O-glycan biosynthesis	10	2.61e-01	-2.05e-01	4.63e-01
Eukaryotic Translation Elongation	72	2.64e-03	-2.05e-01	2.06e-02
ABC transporter disorders	59	6.47e-03	-2.05e-01	3.63e-02
TP53 Regulates Transcription of Cell Cycle Genes	43	2.04e-02	-2.04e-01	8.08e-02
Regulation of TP53 Activity	136	3.97e-05	-2.04e-01	1.49e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency	78	1.83e-03	-2.04e-01	1.70e-02
Integrin cell surface interactions	25	7.72e-02	-2.04e-01	2.05e-01
Resolution of Sister Chromatid Cohesion	92	7.36e-04	-2.04e-01	8.43e-03
Downstream signaling events of B Cell Receptor (BCR)	70	3.26e-03	-2.03e-01	2.28e-02
RHOBTB GTPase Cycle	29	5.83e-02	-2.03e-01	1.73e-01
Mitochondrial translation termination	83	1.43e-03	-2.03e-01	1.40e-02
UCH proteinases	74	2.78e-03	-2.01e-01	2.09e-02
Activation of NF-kappaB in B cells	57	8.64e-03	-2.01e-01	4.42e-02
InlB-mediated entry of Listeria monocytogenes into host cell	11	2.48e-01	-2.01e-01	4.52e-01
Mitotic Prophase	75	2.65e-03	-2.01e-01	2.06e-02
Antigen processing-Cross presentation	76	2.54e-03	-2.00e-01	2.06e-02
Gap junction trafficking	10	2.74e-01	2.00e-01	4.73e-01
Apoptosis	133	7.34e-05	-1.99e-01	1.87e-03
FLT3 Signaling	32	5.14e-02	-1.99e-01	1.58e-01
Translation initiation complex formation	47	1.86e-02	-1.98e-01	7.56e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	1.70e-01	-1.98e-01	3.60e-01
Nucleotide Excision Repair	99	6.91e-04	-1.98e-01	7.99e-03
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	35	4.35e-02	1.97e-01	1.39e-01
Orc1 removal from chromatin	62	7.27e-03	-1.97e-01	3.95e-02
Glucagon signaling in metabolic regulation	18	1.48e-01	1.97e-01	3.35e-01
Dual Incision in GG-NER	35	4.40e-02	-1.97e-01	1.40e-01
LDL clearance	12	2.38e-01	-1.97e-01	4.41e-01
SUMO E3 ligases SUMOylate target proteins	132	1.00e-04	-1.96e-01	2.15e-03
Processing of SMDT1	13	2.21e-01	-1.96e-01	4.21e-01
Mitochondrial translation	89	1.42e-03	-1.96e-01	1.40e-02
Mitotic Spindle Checkpoint	98	8.76e-04	-1.95e-01	9.75e-03
M Phase	297	9.25e-09	-1.95e-01	1.24e-06
Ribosomal scanning and start codon recognition	47	2.12e-02	-1.94e-01	8.17e-02
Gap-filling DNA repair synthesis and ligation in TC-NER	55	1.28e-02	-1.94e-01	5.80e-02
Downregulation of TGF-beta receptor signaling	26	8.67e-02	-1.94e-01	2.22e-01
Base-Excision Repair, AP Site Formation	15	1.94e-01	-1.94e-01	3.86e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	74	4.15e-03	-1.93e-01	2.69e-02
Hedgehog ligand biogenesis	52	1.62e-02	-1.93e-01	6.83e-02
SUMOylation	138	9.57e-05	-1.93e-01	2.13e-03
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	69	5.68e-03	-1.93e-01	3.37e-02
Formation of tubulin folding intermediates by CCT/TriC	14	2.13e-01	-1.92e-01	4.13e-01
Formation of TC-NER Pre-Incision Complex	46	2.42e-02	-1.92e-01	9.04e-02
Cell Cycle, Mitotic	425	1.79e-11	-1.91e-01	1.08e-08
PTEN Regulation	115	4.19e-04	-1.91e-01	5.43e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	28	8.08e-02	-1.91e-01	2.12e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	28	8.08e-02	-1.91e-01	2.12e-01
NOTCH1 Intracellular Domain Regulates Transcription	37	4.49e-02	-1.90e-01	1.41e-01
Mitochondrial translation elongation	84	2.58e-03	-1.90e-01	2.06e-02
Programmed Cell Death	155	4.47e-05	-1.90e-01	1.52e-03
Glutamate Neurotransmitter Release Cycle	12	2.53e-01	-1.90e-01	4.59e-01
Signaling by TGF-beta Receptor Complex	72	5.35e-03	-1.90e-01	3.21e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	32	6.41e-02	-1.89e-01	1.83e-01
Regulation of expression of SLITs and ROBOs	124	2.82e-04	-1.89e-01	4.41e-03
RHO GTPases activate CIT	14	2.23e-01	-1.88e-01	4.23e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	77	4.54e-03	-1.87e-01	2.86e-02
Loss of Nlp from mitotic centrosomes	56	1.54e-02	-1.87e-01	6.60e-02
Loss of proteins required for interphase microtubule organization from the centrosome	56	1.54e-02	-1.87e-01	6.60e-02
Cell Cycle	530	2.75e-13	-1.87e-01	3.30e-10
SUMOylation of intracellular receptors	19	1.59e-01	-1.87e-01	3.47e-01
Metal ion SLC transporters	16	1.96e-01	-1.87e-01	3.89e-01
RHOQ GTPase cycle	39	4.42e-02	1.86e-01	1.40e-01
Sialic acid metabolism	23	1.22e-01	-1.86e-01	2.91e-01
NOTCH4 Intracellular Domain Regulates Transcription	14	2.29e-01	-1.86e-01	4.28e-01
Influenza Viral RNA Transcription and Replication	113	6.62e-04	-1.86e-01	7.72e-03
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	13	2.46e-01	-1.86e-01	4.51e-01
Signaling by ROBO receptors	154	7.38e-05	-1.85e-01	1.87e-03
Maturation of nucleoprotein	11	2.87e-01	-1.85e-01	4.84e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	48	2.65e-02	-1.85e-01	9.61e-02
NoRC negatively regulates rRNA expression	42	3.81e-02	-1.85e-01	1.28e-01
Anchoring of the basal body to the plasma membrane	80	4.33e-03	-1.85e-01	2.77e-02
G2/M Transition	156	7.13e-05	-1.85e-01	1.87e-03
ABC-family proteins mediated transport	74	6.22e-03	-1.84e-01	3.54e-02
RNA Polymerase III Transcription Termination	21	1.46e-01	-1.83e-01	3.32e-01
Vpr-mediated nuclear import of PICs	32	7.31e-02	-1.83e-01	1.99e-01
Post-translational protein phosphorylation	34	6.49e-02	1.83e-01	1.84e-01
Processive synthesis on the lagging strand	13	2.55e-01	-1.82e-01	4.61e-01
Mitochondrial translation initiation	84	3.92e-03	-1.82e-01	2.59e-02
Prolonged ERK activation events	13	2.57e-01	-1.81e-01	4.61e-01
Myogenesis	13	2.57e-01	-1.81e-01	4.61e-01
Recycling pathway of L1	15	2.24e-01	1.81e-01	4.23e-01
Mitotic G2-G2/M phases	158	9.05e-05	-1.81e-01	2.05e-03
Nuclear events mediated by NFE2L2	67	1.09e-02	-1.80e-01	5.16e-02
Mitotic Prometaphase	158	1.05e-04	-1.79e-01	2.20e-03
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	35	6.66e-02	-1.79e-01	1.87e-01
Nucleotide biosynthesis	12	2.83e-01	1.79e-01	4.80e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	28	1.01e-01	-1.79e-01	2.51e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	83	4.86e-03	-1.79e-01	2.99e-02
Amplification of signal from the kinetochores	83	4.86e-03	-1.79e-01	2.99e-02
TRAF6 mediated IRF7 activation	16	2.17e-01	-1.78e-01	4.16e-01
Estrogen-dependent gene expression	70	9.97e-03	-1.78e-01	4.93e-02
Sphingolipid de novo biosynthesis	22	1.49e-01	1.78e-01	3.36e-01
FCGR3A-mediated phagocytosis	42	4.61e-02	-1.78e-01	1.44e-01
Leishmania phagocytosis	42	4.61e-02	-1.78e-01	1.44e-01
Parasite infection	42	4.61e-02	-1.78e-01	1.44e-01
CLEC7A (Dectin-1) induces NFAT activation	11	3.07e-01	-1.78e-01	5.10e-01
Export of Viral Ribonucleoproteins from Nucleus	31	8.79e-02	-1.77e-01	2.23e-01
DNA Repair	248	1.80e-06	-1.77e-01	1.20e-04
Signaling by FGFR	52	2.76e-02	-1.77e-01	9.96e-02
Protein folding	63	1.56e-02	-1.76e-01	6.67e-02
RHOJ GTPase cycle	37	6.44e-02	1.76e-01	1.83e-01
Nuclear Envelope Breakdown	49	3.34e-02	-1.76e-01	1.15e-01
Selenoamino acid metabolism	78	7.36e-03	-1.76e-01	3.95e-02
Transcriptional regulation of white adipocyte differentiation	56	2.35e-02	-1.75e-01	8.87e-02
Signaling by EGFR	35	7.34e-02	-1.75e-01	2.00e-01
ER Quality Control Compartment (ERQC)	18	1.99e-01	-1.75e-01	3.94e-01
Inflammasomes	16	2.26e-01	-1.75e-01	4.25e-01
Activation of gene expression by SREBF (SREBP)	36	6.97e-02	-1.75e-01	1.92e-01
Nuclear import of Rev protein	31	9.26e-02	-1.75e-01	2.34e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	61	1.89e-02	-1.74e-01	7.65e-02
Signaling by FLT3 fusion proteins	16	2.29e-01	-1.74e-01	4.28e-01
Regulation of IFNA/IFNB signaling	12	2.99e-01	1.73e-01	5.01e-01
Nuclear Envelope (NE) Reassembly	60	2.06e-02	-1.73e-01	8.09e-02
DNA Damage Bypass	42	5.26e-02	-1.73e-01	1.59e-01
Transcriptional regulation of granulopoiesis	25	1.35e-01	-1.73e-01	3.12e-01
Signaling by ERBB2 TMD/JMD mutants	10	3.46e-01	-1.72e-01	5.45e-01
Processive synthesis on the C-strand of the telomere	17	2.20e-01	-1.72e-01	4.20e-01
SUMOylation of DNA damage response and repair proteins	67	1.60e-02	-1.70e-01	6.79e-02
Regulation of PLK1 Activity at G2/M Transition	74	1.15e-02	-1.70e-01	5.37e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	3.29e-01	1.70e-01	5.29e-01
Respiratory electron transport	82	8.03e-03	-1.69e-01	4.20e-02
EML4 and NUDC in mitotic spindle formation	87	6.53e-03	-1.69e-01	3.63e-02
Retinoid metabolism and transport	11	3.33e-01	-1.69e-01	5.32e-01
Signaling by BMP	15	2.59e-01	1.68e-01	4.62e-01
Signaling by the B Cell Receptor (BCR)	90	6.05e-03	-1.68e-01	3.48e-02
Signaling by NOTCH1	51	3.91e-02	-1.67e-01	1.30e-01
rRNA modification in the nucleus and cytosol	49	4.36e-02	-1.67e-01	1.39e-01
Interleukin-15 signaling	11	3.39e-01	-1.67e-01	5.38e-01
Negative epigenetic regulation of rRNA expression	44	5.62e-02	-1.66e-01	1.69e-01
Nephrin family interactions	14	2.83e-01	1.66e-01	4.81e-01
Cellular Senescence	106	3.41e-03	-1.65e-01	2.34e-02
IRS-mediated signalling	21	1.91e-01	1.65e-01	3.84e-01
FCERI mediated NF-kB activation	64	2.29e-02	-1.64e-01	8.73e-02
GPVI-mediated activation cascade	23	1.73e-01	-1.64e-01	3.62e-01
Hedgehog ‘on’ state	63	2.44e-02	-1.64e-01	9.05e-02
Influenza Infection	130	1.27e-03	-1.64e-01	1.32e-02
VxPx cargo-targeting to cilium	16	2.58e-01	1.63e-01	4.61e-01
Host Interactions of HIV factors	106	3.75e-03	-1.63e-01	2.54e-02
Postmitotic nuclear pore complex (NPC) reformation	26	1.50e-01	-1.63e-01	3.37e-01
Cell junction organization	26	1.50e-01	1.63e-01	3.37e-01
Deadenylation of mRNA	23	1.76e-01	-1.63e-01	3.68e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	83	1.06e-02	-1.62e-01	5.03e-02
Transcriptional regulation by RUNX2	84	1.02e-02	-1.62e-01	4.93e-02
Formation of Incision Complex in GG-NER	36	9.28e-02	-1.62e-01	2.34e-01
Transport of Ribonucleoproteins into the Host Nucleus	30	1.27e-01	-1.61e-01	2.99e-01
ROS and RNS production in phagocytes	23	1.83e-01	1.61e-01	3.76e-01
Inwardly rectifying K+ channels	13	3.18e-01	1.60e-01	5.19e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	24	1.76e-01	-1.60e-01	3.67e-01
EPHB-mediated forward signaling	25	1.67e-01	-1.60e-01	3.60e-01
Fc epsilon receptor (FCERI) signaling	107	4.42e-03	-1.59e-01	2.81e-02
SUMOylation of DNA methylation proteins	14	3.02e-01	1.59e-01	5.04e-01
Condensation of Prophase Chromosomes	12	3.41e-01	-1.59e-01	5.38e-01
Transferrin endocytosis and recycling	19	2.32e-01	1.58e-01	4.32e-01
Epigenetic regulation of gene expression	76	1.73e-02	-1.58e-01	7.14e-02
Transcriptional regulation by RUNX1	137	1.46e-03	-1.58e-01	1.40e-02
SUMOylation of DNA replication proteins	43	7.41e-02	-1.57e-01	2.00e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	3.27e-01	-1.57e-01	5.26e-01
Metabolism of RNA	553	3.99e-10	-1.57e-01	9.58e-08
Suppression of phagosomal maturation	12	3.46e-01	-1.57e-01	5.45e-01
Collagen formation	28	1.51e-01	1.57e-01	3.39e-01
NEP/NS2 Interacts with the Cellular Export Machinery	30	1.38e-01	-1.57e-01	3.16e-01
Signaling by FGFR2	48	6.12e-02	-1.56e-01	1.78e-01
Rev-mediated nuclear export of HIV RNA	33	1.21e-01	-1.56e-01	2.88e-01
HCMV Early Events	50	5.72e-02	-1.56e-01	1.70e-01
Pre-NOTCH Processing in Golgi	16	2.82e-01	1.55e-01	4.79e-01
CLEC7A (Dectin-1) signaling	84	1.41e-02	-1.55e-01	6.18e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	88	1.20e-02	-1.55e-01	5.55e-02
Nonsense-Mediated Decay (NMD)	88	1.20e-02	-1.55e-01	5.55e-02
Nuclear events stimulated by ALK signaling in cancer	14	3.16e-01	-1.55e-01	5.18e-01
Collagen degradation	14	3.17e-01	1.55e-01	5.18e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	58	4.20e-02	-1.54e-01	1.37e-01
Signaling by TGFB family members	85	1.39e-02	-1.54e-01	6.12e-02
AKT phosphorylates targets in the cytosol	13	3.35e-01	1.54e-01	5.36e-01
Ephrin signaling	12	3.55e-01	1.54e-01	5.55e-01
Regulation of PTEN gene transcription	48	6.69e-02	-1.53e-01	1.87e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	4.04e-01	-1.52e-01	5.98e-01
alpha-linolenic acid (ALA) metabolism	10	4.04e-01	-1.52e-01	5.98e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	10	4.06e-01	-1.52e-01	6.00e-01
Synaptic adhesion-like molecules	10	4.06e-01	1.52e-01	6.00e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	48	6.94e-02	-1.51e-01	1.92e-01
Interactions of Vpr with host cellular proteins	33	1.32e-01	-1.51e-01	3.07e-01
EPH-Ephrin signaling	55	5.25e-02	-1.51e-01	1.59e-01
NOTCH3 Intracellular Domain Regulates Transcription	15	3.10e-01	-1.51e-01	5.12e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	12	3.65e-01	1.51e-01	5.63e-01
Hedgehog ‘off’ state	75	2.42e-02	-1.51e-01	9.04e-02
RHO GTPase Effectors	188	3.91e-04	-1.50e-01	5.26e-03
Ub-specific processing proteases	134	2.82e-03	-1.50e-01	2.10e-02
Nuclear Receptor transcription pathway	27	1.79e-01	-1.49e-01	3.70e-01
KEAP1-NFE2L2 pathway	86	1.69e-02	-1.49e-01	7.07e-02
Signaling by NOTCH	135	2.85e-03	-1.49e-01	2.10e-02
RHO GTPases Activate Formins	102	9.43e-03	-1.49e-01	4.76e-02
N-Glycan antennae elongation	10	4.15e-01	-1.49e-01	6.04e-01
Aquaporin-mediated transport	25	2.00e-01	1.48e-01	3.95e-01
Cargo recognition for clathrin-mediated endocytosis	63	4.25e-02	-1.48e-01	1.37e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	29	1.71e-01	-1.47e-01	3.60e-01
Signaling by RAS mutants	29	1.71e-01	-1.47e-01	3.60e-01
Signaling by moderate kinase activity BRAF mutants	29	1.71e-01	-1.47e-01	3.60e-01
Signaling downstream of RAS mutants	29	1.71e-01	-1.47e-01	3.60e-01
Telomere Extension By Telomerase	20	2.55e-01	-1.47e-01	4.61e-01
PCP/CE pathway	71	3.28e-02	-1.47e-01	1.13e-01
Collagen biosynthesis and modifying enzymes	19	2.70e-01	1.46e-01	4.72e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	10	4.23e-01	-1.46e-01	6.13e-01
Dual incision in TC-NER	56	5.87e-02	-1.46e-01	1.73e-01
Cellular response to heat stress	80	2.44e-02	-1.46e-01	9.05e-02
B-WICH complex positively regulates rRNA expression	27	1.90e-01	-1.46e-01	3.84e-01
Interleukin-1 signaling	79	2.58e-02	-1.45e-01	9.42e-02
Metabolism of fat-soluble vitamins	13	3.66e-01	-1.45e-01	5.63e-01
G1/S-Specific Transcription	27	1.94e-01	-1.45e-01	3.86e-01
Activation of G protein gated Potassium channels	12	3.86e-01	1.45e-01	5.82e-01
G protein gated Potassium channels	12	3.86e-01	1.45e-01	5.82e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	12	3.86e-01	1.45e-01	5.82e-01
Signalling to RAS	12	3.86e-01	-1.44e-01	5.82e-01
Interactions of Rev with host cellular proteins	34	1.46e-01	-1.44e-01	3.32e-01
RORA activates gene expression	11	4.08e-01	-1.44e-01	6.00e-01
Signal transduction by L1	11	4.08e-01	-1.44e-01	6.00e-01
MicroRNA (miRNA) biogenesis	21	2.53e-01	1.44e-01	4.59e-01
Signaling by ERBB2 in Cancer	13	3.69e-01	-1.44e-01	5.66e-01
RHO GTPases activate PKNs	26	2.05e-01	-1.44e-01	4.03e-01
GPCR ligand binding	80	2.66e-02	1.43e-01	9.64e-02
TCF dependent signaling in response to WNT	119	7.36e-03	-1.42e-01	3.95e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	26	2.09e-01	-1.42e-01	4.09e-01
Downstream TCR signaling	71	3.84e-02	-1.42e-01	1.28e-01
FCERI mediated Ca+2 mobilization	23	2.38e-01	-1.42e-01	4.41e-01
KSRP (KHSRP) binds and destabilizes mRNA	15	3.41e-01	-1.42e-01	5.38e-01
Mitochondrial calcium ion transport	19	2.84e-01	-1.42e-01	4.81e-01
Glutathione conjugation	21	2.60e-01	-1.42e-01	4.62e-01
Metalloprotease DUBs	17	3.12e-01	-1.42e-01	5.15e-01
ABC transporters in lipid homeostasis	10	4.39e-01	-1.41e-01	6.25e-01
RNA Polymerase III Abortive And Retractive Initiation	39	1.27e-01	-1.41e-01	2.99e-01
RNA Polymerase III Transcription	39	1.27e-01	-1.41e-01	2.99e-01
Assembly Of The HIV Virion	14	3.61e-01	1.41e-01	5.60e-01
RHOU GTPase cycle	32	1.68e-01	1.41e-01	3.60e-01
mTORC1-mediated signalling	21	2.65e-01	1.40e-01	4.68e-01
Viral Messenger RNA Synthesis	41	1.20e-01	-1.40e-01	2.87e-01
SUMOylation of chromatin organization proteins	49	8.95e-02	-1.40e-01	2.27e-01
Resolution of D-Loop Structures	29	1.92e-01	-1.40e-01	3.85e-01
Regulation of HSF1-mediated heat shock response	67	4.96e-02	-1.39e-01	1.53e-01
NGF-stimulated transcription	25	2.31e-01	-1.39e-01	4.30e-01
Regulation of TNFR1 signaling	31	1.83e-01	-1.38e-01	3.76e-01
RUNX2 regulates osteoblast differentiation	13	3.89e-01	-1.38e-01	5.83e-01
Diseases associated with glycosylation precursor biosynthesis	15	3.57e-01	-1.37e-01	5.57e-01
Transcriptional Regulation by TP53	302	4.55e-05	-1.37e-01	1.52e-03
MTOR signalling	36	1.55e-01	1.37e-01	3.42e-01
C-type lectin receptors (CLRs)	100	1.80e-02	-1.37e-01	7.40e-02
PERK regulates gene expression	26	2.29e-01	-1.36e-01	4.28e-01
TNFR2 non-canonical NF-kB pathway	68	5.20e-02	-1.36e-01	1.58e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	24	2.50e-01	-1.36e-01	4.54e-01
Transcriptional Regulation by E2F6	29	2.06e-01	-1.36e-01	4.05e-01
ATF4 activates genes in response to endoplasmic reticulum stress	23	2.60e-01	-1.36e-01	4.62e-01
SARS-CoV-2 modulates host translation machinery	39	1.44e-01	-1.35e-01	3.29e-01
RAS processing	15	3.65e-01	-1.35e-01	5.63e-01
Signaling by ALK	18	3.21e-01	-1.35e-01	5.22e-01
Signalling to ERKs	25	2.43e-01	-1.35e-01	4.48e-01
RUNX3 regulates NOTCH signaling	11	4.40e-01	-1.34e-01	6.25e-01
Signaling by cytosolic FGFR1 fusion mutants	16	3.56e-01	-1.33e-01	5.55e-01
Recruitment of NuMA to mitotic centrosomes	65	6.35e-02	-1.33e-01	1.81e-01
Activation of the pre-replicative complex	30	2.07e-01	-1.33e-01	4.07e-01
NS1 Mediated Effects on Host Pathways	38	1.57e-01	-1.33e-01	3.44e-01
Disorders of transmembrane transporters	111	1.62e-02	-1.32e-01	6.83e-02
Citric acid cycle (TCA cycle)	19	3.18e-01	1.32e-01	5.19e-01
Class A/1 (Rhodopsin-like receptors)	49	1.10e-01	1.32e-01	2.66e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	23	2.73e-01	1.32e-01	4.73e-01
Generic Transcription Pathway	826	2.61e-10	-1.31e-01	7.85e-08
Pausing and recovery of Tat-mediated HIV elongation	26	2.47e-01	-1.31e-01	4.51e-01
Tat-mediated HIV elongation arrest and recovery	26	2.47e-01	-1.31e-01	4.51e-01
ESR-mediated signaling	115	1.54e-02	-1.31e-01	6.60e-02
NRAGE signals death through JNK	30	2.15e-01	1.31e-01	4.15e-01
Fcgamma receptor (FCGR) dependent phagocytosis	62	7.56e-02	-1.31e-01	2.02e-01
RET signaling	23	2.79e-01	1.30e-01	4.76e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	11	4.55e-01	-1.30e-01	6.34e-01
Inhibition of DNA recombination at telomere	18	3.39e-01	-1.30e-01	5.38e-01
Signaling by Non-Receptor Tyrosine Kinases	36	1.78e-01	-1.30e-01	3.69e-01
Signaling by PTK6	36	1.78e-01	-1.30e-01	3.69e-01
IRS-related events triggered by IGF1R	22	2.92e-01	1.30e-01	4.91e-01
Gastrin-CREB signalling pathway via PKC and MAPK	11	4.57e-01	-1.29e-01	6.34e-01
tRNA processing	93	3.13e-02	-1.29e-01	1.09e-01
TCR signaling	87	3.78e-02	-1.29e-01	1.27e-01
tRNA modification in the nucleus and cytosol	34	1.93e-01	-1.29e-01	3.86e-01
Activation of BH3-only proteins	27	2.47e-01	1.29e-01	4.51e-01
Mitophagy	25	2.66e-01	-1.29e-01	4.69e-01
Nonhomologous End-Joining (NHEJ)	29	2.33e-01	-1.28e-01	4.33e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	10	4.85e-01	1.28e-01	6.61e-01
G alpha (s) signalling events	48	1.27e-01	1.27e-01	2.99e-01
PINK1-PRKN Mediated Mitophagy	20	3.24e-01	-1.27e-01	5.24e-01
Netrin-1 signaling	25	2.71e-01	1.27e-01	4.73e-01
Activation of BAD and translocation to mitochondria	14	4.10e-01	1.27e-01	6.01e-01
Cilium Assembly	150	7.49e-03	-1.27e-01	4.00e-02
Diseases associated with glycosaminoglycan metabolism	16	3.81e-01	-1.27e-01	5.77e-01
Vasopressin regulates renal water homeostasis via Aquaporins	23	2.94e-01	1.26e-01	4.94e-01
Metabolism of amino acids and derivatives	225	1.14e-03	-1.26e-01	1.23e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation	14	4.13e-01	-1.26e-01	6.04e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	27	2.57e-01	-1.26e-01	4.61e-01
G alpha (z) signalling events	25	2.76e-01	1.26e-01	4.73e-01
COPI-dependent Golgi-to-ER retrograde traffic	66	7.85e-02	-1.25e-01	2.07e-01
Signaling by WNT in cancer	23	2.99e-01	-1.25e-01	5.01e-01
Axon guidance	300	2.10e-04	-1.25e-01	3.66e-03
Cellular response to starvation	120	1.82e-02	-1.25e-01	7.43e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter	27	2.61e-01	-1.25e-01	4.63e-01
Integrin signaling	16	3.87e-01	1.25e-01	5.82e-01
Platelet Aggregation (Plug Formation)	16	3.87e-01	1.25e-01	5.82e-01
tRNA Aminoacylation	23	3.00e-01	-1.25e-01	5.01e-01
Transcriptional Regulation by MECP2	31	2.31e-01	-1.24e-01	4.31e-01
Polymerase switching on the C-strand of the telomere	22	3.14e-01	-1.24e-01	5.17e-01
Extracellular matrix organization	93	4.00e-02	1.23e-01	1.32e-01
Sensory processing of sound	27	2.68e-01	1.23e-01	4.69e-01
Sensory processing of sound by inner hair cells of the cochlea	27	2.68e-01	1.23e-01	4.69e-01
Deubiquitination	198	2.90e-03	-1.23e-01	2.10e-02
Cell-Cell communication	48	1.40e-01	1.23e-01	3.22e-01
RND2 GTPase cycle	34	2.15e-01	1.23e-01	4.15e-01
Nuclear Events (kinase and transcription factor activation)	42	1.69e-01	-1.23e-01	3.60e-01
Telomere C-strand synthesis initiation	10	5.02e-01	-1.23e-01	6.76e-01
mRNA Splicing	158	7.95e-03	-1.23e-01	4.17e-02
Gene expression (Transcription)	1040	5.74e-11	-1.23e-01	2.30e-08
Cytosolic sulfonation of small molecules	10	5.03e-01	-1.22e-01	6.77e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	10	5.03e-01	1.22e-01	6.77e-01
Other semaphorin interactions	10	5.05e-01	1.22e-01	6.77e-01
The NLRP3 inflammasome	12	4.67e-01	-1.21e-01	6.46e-01
ADP signalling through P2Y purinoceptor 1	16	4.04e-01	1.20e-01	5.98e-01
HSF1 activation	21	3.40e-01	-1.20e-01	5.38e-01
Neurotransmitter release cycle	20	3.52e-01	-1.20e-01	5.52e-01
Anti-inflammatory response favouring Leishmania parasite infection	54	1.27e-01	1.20e-01	2.99e-01
Leishmania parasite growth and survival	54	1.27e-01	1.20e-01	2.99e-01
activated TAK1 mediates p38 MAPK activation	13	4.56e-01	1.19e-01	6.34e-01
Golgi-to-ER retrograde transport	95	4.48e-02	-1.19e-01	1.41e-01
Class B/2 (Secretin family receptors)	29	2.67e-01	1.19e-01	4.69e-01
Cytoprotection by HMOX1	44	1.72e-01	-1.19e-01	3.62e-01
MAPK1/MAPK3 signaling	164	8.79e-03	-1.19e-01	4.48e-02
Nervous system development	313	3.25e-04	-1.19e-01	4.82e-03
CD209 (DC-SIGN) signaling	15	4.28e-01	-1.18e-01	6.18e-01
Glycosphingolipid metabolism	27	2.89e-01	-1.18e-01	4.87e-01
Signaling by Retinoic Acid	17	4.00e-01	-1.18e-01	5.96e-01
Generation of second messenger molecules	15	4.29e-01	-1.18e-01	6.18e-01
Signaling by CSF3 (G-CSF)	24	3.18e-01	-1.18e-01	5.19e-01
RNA Polymerase II Transcription	927	2.31e-09	-1.18e-01	4.62e-07
HSF1-dependent transactivation	25	3.09e-01	-1.18e-01	5.11e-01
Assembly of the ORC complex at the origin of replication	10	5.21e-01	1.17e-01	6.90e-01
RAF/MAP kinase cascade	159	1.12e-02	-1.17e-01	5.28e-02
Regulation of MECP2 expression and activity	23	3.32e-01	-1.17e-01	5.32e-01
Diseases of metabolism	126	2.38e-02	-1.17e-01	8.95e-02
Attenuation phase	19	3.79e-01	-1.16e-01	5.77e-01
mRNA Splicing - Minor Pathway	49	1.59e-01	-1.16e-01	3.47e-01
Centrosome maturation	66	1.03e-01	-1.16e-01	2.54e-01
Recruitment of mitotic centrosome proteins and complexes	66	1.03e-01	-1.16e-01	2.54e-01
Processing of Capped Intron-Containing Pre-mRNA	199	5.00e-03	-1.16e-01	3.05e-02
Signaling by WNT	177	8.19e-03	-1.16e-01	4.22e-02
ADORA2B mediated anti-inflammatory cytokines production	33	2.51e-01	1.15e-01	4.57e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	11	5.08e-01	-1.15e-01	6.80e-01
PIP3 activates AKT signaling	185	7.08e-03	-1.15e-01	3.87e-02
Metabolism of vitamins and cofactors	111	3.68e-02	-1.15e-01	1.25e-01
Metabolism of non-coding RNA	48	1.69e-01	-1.15e-01	3.60e-01
snRNP Assembly	48	1.69e-01	-1.15e-01	3.60e-01
Plasma lipoprotein assembly, remodeling, and clearance	39	2.16e-01	-1.15e-01	4.16e-01
Semaphorin interactions	39	2.17e-01	-1.14e-01	4.16e-01
Phase II - Conjugation of compounds	46	1.81e-01	-1.14e-01	3.73e-01
Metabolism of water-soluble vitamins and cofactors	82	7.44e-02	-1.14e-01	2.00e-01
N-glycan antennae elongation in the medial/trans-Golgi	17	4.15e-01	1.14e-01	6.04e-01
Synthesis of substrates in N-glycan biosythesis	48	1.72e-01	-1.14e-01	3.62e-01
mRNA Splicing - Major Pathway	148	1.71e-02	-1.14e-01	7.10e-02
Asparagine N-linked glycosylation	225	3.42e-03	-1.14e-01	2.34e-02
Purine ribonucleoside monophosphate biosynthesis	10	5.35e-01	1.13e-01	7.00e-01
RHOB GTPase cycle	44	1.95e-01	1.13e-01	3.87e-01
Oxidative Stress Induced Senescence	55	1.48e-01	-1.13e-01	3.35e-01
Cytosolic sensors of pathogen-associated DNA	53	1.57e-01	-1.12e-01	3.44e-01
Role of phospholipids in phagocytosis	16	4.40e-01	1.12e-01	6.25e-01
Signaling by Nuclear Receptors	151	1.91e-02	-1.11e-01	7.68e-02
MAPK targets/ Nuclear events mediated by MAP kinases	23	3.59e-01	-1.11e-01	5.57e-01
RNA Polymerase II Pre-transcription Events	68	1.16e-01	-1.10e-01	2.79e-01
Signaling by FGFR1 in disease	24	3.50e-01	-1.10e-01	5.49e-01
Cargo concentration in the ER	20	3.95e-01	-1.10e-01	5.90e-01
HIV elongation arrest and recovery	27	3.24e-01	-1.10e-01	5.24e-01
Pausing and recovery of HIV elongation	27	3.24e-01	-1.10e-01	5.24e-01
The citric acid (TCA) cycle and respiratory electron transport	121	3.77e-02	-1.10e-01	1.27e-01
Prostacyclin signalling through prostacyclin receptor	12	5.12e-01	1.09e-01	6.81e-01
Signaling by ERBB2	33	2.77e-01	-1.09e-01	4.73e-01
Detoxification of Reactive Oxygen Species	23	3.65e-01	1.09e-01	5.63e-01
Bile acid and bile salt metabolism	15	4.65e-01	1.09e-01	6.44e-01
NCAM signaling for neurite out-growth	24	3.58e-01	-1.08e-01	5.57e-01
Inactivation of CSF3 (G-CSF) signaling	19	4.14e-01	-1.08e-01	6.04e-01
MAPK family signaling cascades	191	1.03e-02	-1.08e-01	4.93e-02
Intra-Golgi and retrograde Golgi-to-ER traffic	158	1.95e-02	-1.08e-01	7.84e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex	10	5.55e-01	-1.08e-01	7.17e-01
Beta-catenin independent WNT signaling	106	5.65e-02	-1.07e-01	1.69e-01
Organelle biogenesis and maintenance	204	8.48e-03	-1.07e-01	4.35e-02
Other interleukin signaling	15	4.73e-01	-1.07e-01	6.52e-01
Inactivation, recovery and regulation of the phototransduction cascade	17	4.45e-01	-1.07e-01	6.31e-01
Interferon alpha/beta signaling	51	1.87e-01	1.07e-01	3.82e-01
Josephin domain DUBs	11	5.41e-01	-1.06e-01	7.05e-01
Transcription of the HIV genome	57	1.66e-01	-1.06e-01	3.58e-01
Peroxisomal lipid metabolism	22	3.89e-01	1.06e-01	5.83e-01
Activation of GABAB receptors	18	4.37e-01	1.06e-01	6.25e-01
GABA B receptor activation	18	4.37e-01	1.06e-01	6.25e-01
tRNA processing in the nucleus	55	1.75e-01	-1.06e-01	3.67e-01
RNA Polymerase III Chain Elongation	17	4.51e-01	-1.06e-01	6.34e-01
Interleukin-1 family signaling	99	7.00e-02	-1.06e-01	1.92e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	449	1.51e-04	-1.05e-01	2.83e-03
p75 NTR receptor-mediated signalling	59	1.63e-01	-1.05e-01	3.53e-01
Uptake and actions of bacterial toxins	18	4.40e-01	-1.05e-01	6.25e-01
Developmental Biology	468	1.12e-04	-1.05e-01	2.24e-03
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	33	2.97e-01	-1.05e-01	4.97e-01
Cellular response to chemical stress	145	3.00e-02	-1.05e-01	1.07e-01
E2F mediated regulation of DNA replication	19	4.30e-01	-1.05e-01	6.18e-01
COPI-independent Golgi-to-ER retrograde traffic	29	3.31e-01	-1.04e-01	5.31e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	27	3.49e-01	1.04e-01	5.48e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	26	3.59e-01	-1.04e-01	5.57e-01
Synthesis of very long-chain fatty acyl-CoAs	16	4.72e-01	1.04e-01	6.51e-01
Regulation of lipid metabolism by PPARalpha	84	1.01e-01	-1.04e-01	2.51e-01
Energy dependent regulation of mTOR by LKB1-AMPK	25	3.74e-01	1.03e-01	5.72e-01
Metabolism of proteins	1246	2.76e-09	-1.03e-01	4.74e-07
Signaling by NODAL	12	5.40e-01	1.02e-01	7.05e-01
FOXO-mediated transcription of cell cycle genes	13	5.24e-01	-1.02e-01	6.93e-01
Cell-cell junction organization	13	5.24e-01	1.02e-01	6.93e-01
A tetrasaccharide linker sequence is required for GAG synthesis	10	5.77e-01	1.02e-01	7.35e-01
TGF-beta receptor signaling activates SMADs	39	2.72e-01	-1.02e-01	4.73e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	23	3.99e-01	-1.02e-01	5.95e-01
TRAF3-dependent IRF activation pathway	14	5.10e-01	-1.02e-01	6.81e-01
Glucose metabolism	72	1.37e-01	-1.01e-01	3.16e-01
GPER1 signaling	25	3.81e-01	1.01e-01	5.77e-01
Diseases of signal transduction by growth factor receptors and second messengers	299	2.75e-03	-1.01e-01	2.08e-02
GABA receptor activation	19	4.45e-01	1.01e-01	6.31e-01
Synthesis of PIPs at the Golgi membrane	12	5.45e-01	-1.01e-01	7.08e-01
Retrograde transport at the Trans-Golgi-Network	45	2.43e-01	-1.01e-01	4.48e-01
HIV Transcription Initiation	39	2.77e-01	-1.01e-01	4.73e-01
RNA Polymerase II HIV Promoter Escape	39	2.77e-01	-1.01e-01	4.73e-01
RNA Polymerase II Promoter Escape	39	2.77e-01	-1.01e-01	4.73e-01
RNA Polymerase II Transcription Initiation	39	2.77e-01	-1.01e-01	4.73e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	39	2.77e-01	-1.01e-01	4.73e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	39	2.77e-01	-1.01e-01	4.73e-01
Signaling by ERBB2 KD Mutants	12	5.46e-01	-1.01e-01	7.08e-01
Cellular responses to stress	546	6.87e-05	-1.01e-01	1.87e-03
Signaling by Rho GTPases	437	3.71e-04	-1.00e-01	5.07e-03
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	38	2.86e-01	-9.99e-02	4.84e-01
Ras activation upon Ca2+ influx through NMDA receptor	10	5.84e-01	-9.99e-02	7.42e-01
Diseases of glycosylation	69	1.52e-01	-9.98e-02	3.40e-01
RAF activation	28	3.61e-01	-9.97e-02	5.60e-01
Regulation of IFNG signaling	13	5.34e-01	9.95e-02	7.00e-01
RNA Polymerase III Transcription Initiation	35	3.13e-01	-9.85e-02	5.16e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	36	3.08e-01	-9.82e-02	5.10e-01
HIV Transcription Elongation	36	3.08e-01	-9.82e-02	5.10e-01
Tat-mediated elongation of the HIV-1 transcript	36	3.08e-01	-9.82e-02	5.10e-01
HIV Infection	190	2.00e-02	-9.81e-02	7.98e-02
Disease	1086	9.51e-08	-9.79e-02	9.53e-06
Syndecan interactions	10	5.93e-01	-9.77e-02	7.49e-01
RHOBTB2 GTPase cycle	20	4.49e-01	-9.77e-02	6.34e-01
Synthesis of PC	22	4.29e-01	-9.74e-02	6.18e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	3.83e-01	-9.70e-02	5.80e-01
The phototransduction cascade	18	4.77e-01	-9.69e-02	6.55e-01
Cellular responses to stimuli	551	1.25e-04	-9.65e-02	2.42e-03
Transport of the SLBP independent Mature mRNA	33	3.38e-01	-9.64e-02	5.38e-01
Protein localization	123	6.70e-02	-9.58e-02	1.87e-01
Negative regulation of MET activity	16	5.08e-01	-9.55e-02	6.80e-01
FCGR3A-mediated IL10 synthesis	22	4.38e-01	9.55e-02	6.25e-01
RNA polymerase II transcribes snRNA genes	71	1.66e-01	-9.52e-02	3.57e-01
Phase I - Functionalization of compounds	30	3.68e-01	9.50e-02	5.65e-01
Neddylation	188	2.59e-02	-9.45e-02	9.42e-02
Intracellular signaling by second messengers	210	2.01e-02	-9.34e-02	7.98e-02
Diseases of programmed cell death	37	3.26e-01	-9.34e-02	5.25e-01
ISG15 antiviral mechanism	70	1.78e-01	-9.32e-02	3.69e-01
Cytochrome P450 - arranged by substrate type	14	5.47e-01	9.29e-02	7.09e-01
Formation of RNA Pol II elongation complex	50	2.56e-01	-9.28e-02	4.61e-01
RNA Polymerase II Transcription Elongation	50	2.56e-01	-9.28e-02	4.61e-01
Signaling by high-kinase activity BRAF mutants	22	4.52e-01	-9.27e-02	6.34e-01
COPII-mediated vesicle transport	51	2.58e-01	-9.15e-02	4.61e-01
Cargo trafficking to the periciliary membrane	40	3.17e-01	-9.14e-02	5.18e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	14	5.54e-01	9.13e-02	7.17e-01
COPI-mediated anterograde transport	71	1.85e-01	-9.10e-02	3.79e-01
TAK1-dependent IKK and NF-kappa-B activation	18	5.05e-01	9.08e-02	6.77e-01
Basigin interactions	14	5.59e-01	9.03e-02	7.19e-01
SUMOylation of transcription cofactors	35	3.56e-01	-9.02e-02	5.55e-01
Amino acid transport across the plasma membrane	16	5.33e-01	-9.01e-02	7.00e-01
Metabolic disorders of biological oxidation enzymes	14	5.60e-01	-9.00e-02	7.20e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	16	5.34e-01	-8.98e-02	7.00e-01
IGF1R signaling cascade	23	4.56e-01	8.98e-02	6.34e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	23	4.56e-01	8.98e-02	6.34e-01
Telomere C-strand (Lagging Strand) Synthesis	29	4.04e-01	-8.96e-02	5.98e-01
Defective Intrinsic Pathway for Apoptosis	23	4.57e-01	-8.95e-02	6.34e-01
O-linked glycosylation of mucins	26	4.31e-01	-8.93e-02	6.18e-01
Response to elevated platelet cytosolic Ca2+	53	2.62e-01	-8.92e-02	4.63e-01
Transport of Mature mRNA Derived from an Intronless Transcript	40	3.29e-01	-8.91e-02	5.29e-01
Toll Like Receptor 3 (TLR3) Cascade	74	1.87e-01	-8.88e-02	3.82e-01
FGFR2 mutant receptor activation	17	5.28e-01	8.84e-02	6.96e-01
Signaling by Receptor Tyrosine Kinases	293	9.64e-03	-8.83e-02	4.83e-02
PPARA activates gene expression	82	1.68e-01	-8.81e-02	3.60e-01
MET promotes cell motility	13	5.82e-01	8.81e-02	7.41e-01
Regulation of RUNX1 Expression and Activity	17	5.30e-01	-8.80e-02	6.97e-01
MyD88-independent TLR4 cascade	74	1.91e-01	-8.79e-02	3.84e-01
TRIF(TICAM1)-mediated TLR4 signaling	74	1.91e-01	-8.79e-02	3.84e-01
RNA Pol II CTD phosphorylation and interaction with CE	24	4.57e-01	-8.77e-02	6.34e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	24	4.57e-01	-8.77e-02	6.34e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	26	4.40e-01	8.74e-02	6.25e-01
Aggrephagy	19	5.12e-01	-8.68e-02	6.81e-01
Death Receptor Signalling	96	1.44e-01	-8.63e-02	3.30e-01
Muscle contraction	67	2.24e-01	-8.60e-02	4.23e-01
Late Phase of HIV Life Cycle	117	1.09e-01	-8.60e-02	2.64e-01
Cell surface interactions at the vascular wall	56	2.66e-01	-8.59e-02	4.69e-01
VEGFA-VEGFR2 Pathway	71	2.11e-01	-8.59e-02	4.11e-01
Antigen processing: Ubiquitination & Proteasome degradation	241	2.32e-02	-8.52e-02	8.81e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript	55	2.75e-01	-8.51e-02	4.73e-01
Molecules associated with elastic fibres	12	6.10e-01	8.49e-02	7.63e-01
Glycolysis	57	2.70e-01	-8.45e-02	4.72e-01
MAP2K and MAPK activation	25	4.68e-01	-8.39e-02	6.46e-01
Formation of HIV elongation complex in the absence of HIV Tat	37	3.80e-01	-8.34e-02	5.77e-01
Signaling by FLT3 ITD and TKD mutants	12	6.17e-01	-8.34e-02	7.69e-01
Hemostasis	304	1.30e-02	-8.33e-02	5.86e-02
PI Metabolism	60	2.66e-01	-8.31e-02	4.69e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	5.90e-01	-8.31e-02	7.47e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	10	6.50e-01	8.29e-02	7.88e-01
Platelet degranulation	49	3.17e-01	-8.27e-02	5.18e-01
Antiviral mechanism by IFN-stimulated genes	77	2.11e-01	-8.26e-02	4.11e-01
Chromatin modifying enzymes	158	7.45e-02	-8.24e-02	2.00e-01
Chromatin organization	158	7.45e-02	-8.24e-02	2.00e-01
Transcriptional regulation by small RNAs	45	3.41e-01	-8.20e-02	5.38e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	6.53e-01	8.20e-02	7.89e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	5.71e-01	-8.19e-02	7.31e-01
Intrinsic Pathway for Apoptosis	47	3.33e-01	-8.17e-02	5.32e-01
Visual phototransduction	34	4.11e-01	-8.14e-02	6.02e-01
ZBP1(DAI) mediated induction of type I IFNs	17	5.65e-01	-8.07e-02	7.25e-01
G-protein mediated events	32	4.33e-01	-8.02e-02	6.20e-01
Transcriptional activation of mitochondrial biogenesis	40	3.81e-01	-8.01e-02	5.77e-01
Listeria monocytogenes entry into host cells	14	6.04e-01	-8.01e-02	7.57e-01
HIV Life Cycle	129	1.18e-01	-7.98e-02	2.84e-01
ER to Golgi Anterograde Transport	108	1.54e-01	-7.95e-02	3.42e-01
G alpha (q) signalling events	78	2.26e-01	7.94e-02	4.25e-01
Platelet calcium homeostasis	17	5.73e-01	7.90e-02	7.33e-01
Signal Transduction	1356	2.11e-06	-7.89e-02	1.33e-04
SARS-CoV-2 Infection	213	4.82e-02	-7.88e-02	1.49e-01
SLC-mediated transmembrane transport	105	1.65e-01	7.85e-02	3.57e-01
Regulation of FZD by ubiquitination	12	6.38e-01	-7.83e-02	7.86e-01
Selective autophagy	50	3.41e-01	-7.78e-02	5.38e-01
Azathioprine ADME	15	6.03e-01	7.74e-02	7.57e-01
Neurotransmitter receptors and postsynaptic signal transmission	77	2.42e-01	7.72e-02	4.47e-01
Interleukin-6 signaling	10	6.73e-01	7.70e-02	8.02e-01
MyD88 dependent cascade initiated on endosome	67	2.76e-01	-7.70e-02	4.73e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	67	2.76e-01	-7.70e-02	4.73e-01
Activation of kainate receptors upon glutamate binding	17	5.83e-01	7.69e-02	7.41e-01
TNF signaling	38	4.15e-01	-7.65e-02	6.04e-01
Protein methylation	14	6.21e-01	7.63e-02	7.73e-01
RHO GTPases Activate NADPH Oxidases	14	6.22e-01	7.61e-02	7.73e-01
Signaling by RAF1 mutants	25	5.12e-01	-7.58e-02	6.81e-01
Infectious disease	627	1.42e-03	-7.55e-02	1.40e-02
Toll Like Receptor 9 (TLR9) Cascade	70	2.76e-01	-7.54e-02	4.73e-01
Metabolism of nitric oxide: NOS3 activation and regulation	12	6.52e-01	7.51e-02	7.89e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	10	6.81e-01	-7.50e-02	8.07e-01
Clathrin-mediated endocytosis	89	2.22e-01	-7.50e-02	4.23e-01
SUMOylation of RNA binding proteins	42	4.02e-01	-7.48e-02	5.98e-01
Neuronal System	139	1.30e-01	7.45e-02	3.03e-01
Constitutive Signaling by Aberrant PI3K in Cancer	28	4.96e-01	7.44e-02	6.71e-01
Synthesis of bile acids and bile salts	13	6.43e-01	7.42e-02	7.86e-01
HDACs deacetylate histones	28	4.97e-01	-7.42e-02	6.72e-01
Class I MHC mediated antigen processing & presentation	289	3.09e-02	-7.41e-02	1.08e-01
Toll Like Receptor 4 (TLR4) Cascade	94	2.16e-01	-7.39e-02	4.16e-01
Role of LAT2/NTAL/LAB on calcium mobilization	10	6.88e-01	7.33e-02	8.12e-01
Signaling by Hedgehog	99	2.12e-01	-7.27e-02	4.12e-01
Signaling by VEGF	73	2.86e-01	-7.22e-02	4.84e-01
Signaling by Insulin receptor	42	4.18e-01	7.22e-02	6.08e-01
Pre-NOTCH Transcription and Translation	31	4.87e-01	-7.20e-02	6.64e-01
The role of Nef in HIV-1 replication and disease pathogenesis	19	5.87e-01	-7.20e-02	7.43e-01
SARS-CoV Infections	270	4.25e-02	-7.20e-02	1.37e-01
Signaling by SCF-KIT	32	4.81e-01	-7.20e-02	6.58e-01
Signaling by ERBB4	31	4.95e-01	-7.08e-02	6.71e-01
Interleukin-2 family signaling	28	5.17e-01	-7.08e-02	6.86e-01
Intra-Golgi traffic	39	4.47e-01	-7.03e-02	6.32e-01
Extension of Telomeres	44	4.22e-01	-6.99e-02	6.12e-01
Post-translational protein modification	917	4.38e-04	-6.97e-02	5.49e-03
Metabolism of porphyrins	15	6.42e-01	-6.92e-02	7.86e-01
Chondroitin sulfate/dermatan sulfate metabolism	27	5.34e-01	6.92e-02	7.00e-01
G beta:gamma signalling through BTK	11	6.91e-01	6.91e-02	8.12e-01
Synthesis of PA	18	6.13e-01	-6.88e-02	7.66e-01
Adaptive Immune System	481	1.05e-02	-6.87e-02	5.02e-02
Signaling by NTRK1 (TRKA)	79	2.92e-01	-6.86e-02	4.91e-01
Signaling by BRAF and RAF1 fusions	42	4.42e-01	-6.85e-02	6.28e-01
DAP12 signaling	19	6.06e-01	-6.83e-02	7.59e-01
GPCR downstream signalling	197	1.00e-01	6.82e-02	2.49e-01
Formation of the beta-catenin:TCF transactivating complex	25	5.55e-01	-6.81e-02	7.17e-01
Synthesis of IP3 and IP4 in the cytosol	16	6.37e-01	-6.81e-02	7.86e-01
Platelet activation, signaling and aggregation	132	1.86e-01	-6.69e-02	3.80e-01
Transmission across Chemical Synapses	101	2.46e-01	6.68e-02	4.51e-01
Transport of the SLBP Dependant Mature mRNA	34	5.01e-01	-6.67e-02	6.76e-01
Membrane binding and targetting of GAG proteins	12	6.89e-01	6.67e-02	8.12e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	12	6.89e-01	6.67e-02	8.12e-01
ECM proteoglycans	13	6.78e-01	6.66e-02	8.04e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	29	5.36e-01	-6.63e-02	7.01e-01
Lysosome Vesicle Biogenesis	24	5.75e-01	-6.61e-02	7.35e-01
Pyruvate metabolism	20	6.10e-01	-6.59e-02	7.63e-01
Negative regulators of DDX58/IFIH1 signaling	34	5.12e-01	-6.49e-02	6.81e-01
Plasma lipoprotein remodeling	11	7.09e-01	6.49e-02	8.26e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	41	4.74e-01	-6.47e-02	6.52e-01
Synthesis of glycosylphosphatidylinositol (GPI)	14	6.75e-01	-6.46e-02	8.03e-01
Diseases associated with the TLR signaling cascade	17	6.45e-01	6.45e-02	7.86e-01
Diseases of Immune System	17	6.45e-01	6.45e-02	7.86e-01
Signaling by FGFR in disease	39	4.87e-01	-6.43e-02	6.64e-01
Signaling by GPCR	216	1.05e-01	6.43e-02	2.58e-01
Triglyceride metabolism	16	6.56e-01	-6.42e-02	7.92e-01
Transport to the Golgi and subsequent modification	130	2.10e-01	-6.38e-02	4.10e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	66	3.72e-01	-6.36e-02	5.70e-01
Gene Silencing by RNA	62	3.89e-01	-6.33e-02	5.83e-01
Signaling by MET	41	4.84e-01	-6.32e-02	6.61e-01
Cell recruitment (pro-inflammatory response)	15	6.73e-01	-6.29e-02	8.02e-01
Purinergic signaling in leishmaniasis infection	15	6.73e-01	-6.29e-02	8.02e-01
Glucagon-type ligand receptors	14	6.85e-01	6.26e-02	8.11e-01
NR1H2 and NR1H3-mediated signaling	27	5.77e-01	6.21e-02	7.35e-01
Cytokine Signaling in Immune system	427	2.92e-02	-6.20e-02	1.05e-01
Neurexins and neuroligins	21	6.23e-01	6.20e-02	7.73e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	16	6.69e-01	-6.18e-02	8.01e-01
trans-Golgi Network Vesicle Budding	51	4.47e-01	-6.16e-02	6.32e-01
Signaling by NTRKs	87	3.22e-01	-6.16e-02	5.22e-01
Factors involved in megakaryocyte development and platelet production	87	3.22e-01	-6.15e-02	5.22e-01
Interleukin-7 signaling	14	6.92e-01	6.11e-02	8.12e-01
RHO GTPase cycle	294	7.69e-02	-6.03e-02	2.05e-01
ERK/MAPK targets	16	6.76e-01	-6.02e-02	8.03e-01
Macroautophagy	97	3.08e-01	-6.00e-02	5.10e-01
Diseases associated with O-glycosylation of proteins	21	6.35e-01	5.98e-02	7.86e-01
mRNA Capping	26	5.97e-01	-5.98e-02	7.52e-01
Signal amplification	20	6.45e-01	5.95e-02	7.86e-01
MyD88 cascade initiated on plasma membrane	65	4.09e-01	-5.93e-02	6.00e-01
Toll Like Receptor 10 (TLR10) Cascade	65	4.09e-01	-5.93e-02	6.00e-01
Toll Like Receptor 5 (TLR5) Cascade	65	4.09e-01	-5.93e-02	6.00e-01
Unfolded Protein Response (UPR)	76	3.76e-01	-5.87e-02	5.76e-01
Signaling by ALK fusions and activated point mutants	46	4.94e-01	-5.83e-02	6.70e-01
Signaling by ALK in cancer	46	4.94e-01	-5.83e-02	6.70e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	16	6.87e-01	5.82e-02	8.12e-01
Immune System	1156	1.26e-03	-5.76e-02	1.32e-02
Activation of HOX genes during differentiation	41	5.28e-01	-5.70e-02	6.96e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	41	5.28e-01	-5.70e-02	6.96e-01
TP53 Regulates Transcription of Cell Death Genes	31	5.83e-01	-5.69e-02	7.41e-01
Metabolism of nucleotides	73	4.01e-01	5.69e-02	5.98e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	29	5.97e-01	-5.66e-02	7.52e-01
Circadian Clock	52	4.81e-01	-5.65e-02	6.58e-01
FGFR1 mutant receptor activation	20	6.62e-01	-5.64e-02	7.98e-01
Interferon Signaling	142	2.47e-01	-5.64e-02	4.51e-01
Signaling by Interleukins	265	1.16e-01	-5.64e-02	2.79e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	22	6.47e-01	5.64e-02	7.87e-01
XBP1(S) activates chaperone genes	42	5.31e-01	5.58e-02	6.99e-01
CaM pathway	20	6.66e-01	5.58e-02	8.00e-01
Calmodulin induced events	20	6.66e-01	5.58e-02	8.00e-01
MHC class II antigen presentation	69	4.25e-01	-5.56e-02	6.15e-01
Insulin receptor recycling	17	6.92e-01	5.54e-02	8.12e-01
Kinesins	32	5.93e-01	-5.45e-02	7.49e-01
Signaling by PDGF	25	6.37e-01	-5.45e-02	7.86e-01
Disorders of Developmental Biology	10	7.67e-01	-5.42e-02	8.71e-01
Disorders of Nervous System Development	10	7.67e-01	-5.42e-02	8.71e-01
Loss of function of MECP2 in Rett syndrome	10	7.67e-01	-5.42e-02	8.71e-01
Pervasive developmental disorders	10	7.67e-01	-5.42e-02	8.71e-01
PLC beta mediated events	29	6.18e-01	-5.35e-02	7.70e-01
Metabolism	1253	1.94e-03	-5.34e-02	1.74e-02
Insulin receptor signalling cascade	26	6.38e-01	5.33e-02	7.86e-01
Stimuli-sensing channels	39	5.70e-01	5.26e-02	7.31e-01
RAC1 GTPase cycle	110	3.41e-01	-5.26e-02	5.38e-01
Interleukin-20 family signaling	13	7.43e-01	-5.25e-02	8.58e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	20	6.85e-01	-5.23e-02	8.11e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	45	5.45e-01	5.21e-02	7.08e-01
SHC1 events in ERBB2 signaling	11	7.65e-01	-5.21e-02	8.71e-01
Telomere Maintenance	57	4.98e-01	-5.19e-02	6.73e-01
CDC42 GTPase cycle	97	3.79e-01	5.17e-02	5.77e-01
DAG and IP3 signaling	26	6.48e-01	5.17e-02	7.87e-01
Integration of energy metabolism	60	4.89e-01	-5.17e-02	6.65e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	71	4.53e-01	-5.15e-02	6.34e-01
Toll Like Receptor 2 (TLR2) Cascade	71	4.53e-01	-5.15e-02	6.34e-01
Toll Like Receptor TLR1:TLR2 Cascade	71	4.53e-01	-5.15e-02	6.34e-01
Toll Like Receptor TLR6:TLR2 Cascade	71	4.53e-01	-5.15e-02	6.34e-01
Toll-like Receptor Cascades	108	3.62e-01	-5.08e-02	5.60e-01
Mitochondrial biogenesis	54	5.19e-01	-5.08e-02	6.88e-01
Transport of Mature Transcript to Cytoplasm	64	4.84e-01	-5.06e-02	6.61e-01
Metabolism of carbohydrates	181	2.43e-01	-5.05e-02	4.48e-01
Interconversion of nucleotide di- and triphosphates	25	6.64e-01	5.02e-02	8.00e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	29	6.44e-01	-4.96e-02	7.86e-01
Arachidonic acid metabolism	21	6.99e-01	4.87e-02	8.18e-01
SLC transporter disorders	52	5.45e-01	-4.85e-02	7.08e-01
Regulation of signaling by CBL	14	7.54e-01	4.84e-02	8.63e-01
PRC2 methylates histones and DNA	12	7.73e-01	-4.81e-02	8.74e-01
Peptide hormone metabolism	31	6.45e-01	-4.78e-02	7.86e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	12	7.75e-01	-4.77e-02	8.74e-01
Trafficking of AMPA receptors	12	7.75e-01	-4.77e-02	8.74e-01
Intraflagellar transport	33	6.36e-01	-4.76e-02	7.86e-01
TNFR1-induced NFkappaB signaling pathway	20	7.13e-01	4.75e-02	8.28e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	31	6.50e-01	4.71e-02	7.88e-01
Vitamin B5 (pantothenate) metabolism	11	7.87e-01	-4.70e-02	8.83e-01
Metabolism of steroids	86	4.56e-01	-4.65e-02	6.34e-01
Processing of Capped Intronless Pre-mRNA	23	7.01e-01	4.62e-02	8.20e-01
Signaling by NTRK3 (TRKC)	11	7.91e-01	-4.62e-02	8.84e-01
Membrane Trafficking	446	9.93e-02	-4.59e-02	2.48e-01
Interferon gamma signaling	55	5.57e-01	4.58e-02	7.17e-01
Signaling by KIT in disease	16	7.51e-01	-4.57e-02	8.63e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	16	7.51e-01	-4.57e-02	8.63e-01
Activation of NMDA receptors and postsynaptic events	44	6.00e-01	4.57e-02	7.54e-01
Heparan sulfate/heparin (HS-GAG) metabolism	22	7.12e-01	4.54e-02	8.28e-01
G beta:gamma signalling through PI3Kgamma	17	7.46e-01	4.54e-02	8.58e-01
Deposition of new CENPA-containing nucleosomes at the centromere	23	7.09e-01	4.50e-02	8.26e-01
Nucleosome assembly	23	7.09e-01	4.50e-02	8.26e-01
Dopamine Neurotransmitter Release Cycle	12	7.88e-01	-4.48e-02	8.83e-01
Vesicle-mediated transport	454	1.05e-01	-4.48e-02	2.58e-01
G-protein beta:gamma signalling	21	7.23e-01	-4.47e-02	8.37e-01
RAC3 GTPase cycle	59	5.56e-01	-4.43e-02	7.17e-01
Growth hormone receptor signaling	17	7.59e-01	-4.29e-02	8.68e-01
RHOA GTPase cycle	93	4.80e-01	-4.24e-02	6.58e-01
L1CAM interactions	41	6.40e-01	4.23e-02	7.86e-01
SARS-CoV-2-host interactions	150	3.79e-01	-4.17e-02	5.77e-01
HCMV Infection	71	5.44e-01	-4.16e-02	7.08e-01
Inositol phosphate metabolism	30	6.95e-01	-4.13e-02	8.15e-01
Innate Immune System	620	8.78e-02	-4.06e-02	2.23e-01
Autophagy	106	4.74e-01	-4.03e-02	6.52e-01
Nucleotide salvage	18	7.69e-01	3.99e-02	8.73e-01
Phospholipid metabolism	133	4.27e-01	-3.99e-02	6.18e-01
HATs acetylate histones	63	5.87e-01	-3.96e-02	7.43e-01
DARPP-32 events	21	7.54e-01	3.95e-02	8.63e-01
Post NMDA receptor activation events	38	6.74e-01	3.95e-02	8.02e-01
Ca2+ pathway	40	6.68e-01	-3.92e-02	8.01e-01
Metabolism of cofactors	17	7.80e-01	-3.91e-02	8.78e-01
Late endosomal microautophagy	23	7.46e-01	3.90e-02	8.58e-01
Sulfur amino acid metabolism	17	7.82e-01	-3.88e-02	8.79e-01
Downstream signal transduction	20	7.64e-01	-3.87e-02	8.71e-01
Mitochondrial Fatty Acid Beta-Oxidation	26	7.35e-01	-3.84e-02	8.49e-01
Regulation of pyruvate dehydrogenase (PDH) complex	11	8.26e-01	-3.83e-02	9.07e-01
Extra-nuclear estrogen signaling	49	6.45e-01	-3.81e-02	7.86e-01
Downstream signaling of activated FGFR1	12	8.19e-01	-3.80e-02	9.06e-01
Downstream signaling of activated FGFR2	12	8.19e-01	-3.80e-02	9.06e-01
Downstream signaling of activated FGFR3	12	8.19e-01	-3.80e-02	9.06e-01
Downstream signaling of activated FGFR4	12	8.19e-01	-3.80e-02	9.06e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	33	7.06e-01	-3.80e-02	8.24e-01
Oncogenic MAPK signaling	56	6.23e-01	-3.80e-02	7.73e-01
MAP kinase activation	49	6.48e-01	-3.77e-02	7.87e-01
PI3K/AKT Signaling in Cancer	52	6.40e-01	3.75e-02	7.86e-01
Budding and maturation of HIV virion	24	7.53e-01	3.71e-02	8.63e-01
IRE1alpha activates chaperones	43	6.75e-01	3.69e-02	8.03e-01
Binding and Uptake of Ligands by Scavenger Receptors	10	8.41e-01	3.67e-02	9.14e-01
Hyaluronan metabolism	11	8.35e-01	-3.64e-02	9.10e-01
Signaling by Activin	12	8.28e-01	3.62e-02	9.07e-01
Mismatch Repair	13	8.22e-01	3.61e-02	9.07e-01
Assembly and cell surface presentation of NMDA receptors	13	8.24e-01	3.57e-02	9.07e-01
Mitochondrial protein import	48	6.71e-01	-3.54e-02	8.02e-01
Glycosaminoglycan metabolism	64	6.25e-01	3.54e-02	7.74e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	41	6.96e-01	3.53e-02	8.15e-01
Transport of bile salts and organic acids, metal ions and amine compounds	34	7.23e-01	-3.51e-02	8.37e-01
Chromosome Maintenance	78	5.97e-01	-3.47e-02	7.52e-01
Opioid Signalling	58	6.53e-01	-3.42e-02	7.89e-01
Signaling by FGFR2 in disease	24	7.74e-01	3.38e-02	8.74e-01
Ion homeostasis	26	7.66e-01	-3.36e-02	8.71e-01
Hyaluronan uptake and degradation	10	8.54e-01	-3.36e-02	9.19e-01
Rab regulation of trafficking	94	5.77e-01	-3.33e-02	7.35e-01
Cholesterol biosynthesis	22	7.89e-01	3.29e-02	8.83e-01
DAP12 interactions	21	7.95e-01	3.27e-02	8.86e-01
Rap1 signalling	11	8.51e-01	-3.27e-02	9.18e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	15	8.27e-01	-3.27e-02	9.07e-01
Potential therapeutics for SARS	66	6.47e-01	-3.26e-02	7.87e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	50	6.90e-01	-3.26e-02	8.12e-01
CD28 co-stimulation	27	7.70e-01	-3.25e-02	8.73e-01
FOXO-mediated transcription of cell death genes	14	8.35e-01	-3.21e-02	9.10e-01
Nuclear signaling by ERBB4	16	8.26e-01	3.18e-02	9.07e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	21	8.01e-01	-3.18e-02	8.91e-01
Peroxisomal protein import	48	7.11e-01	-3.09e-02	8.27e-01
RNA Polymerase II Transcription Termination	45	7.23e-01	3.06e-02	8.37e-01
Signaling by Hippo	12	8.55e-01	-3.05e-02	9.19e-01
PKMTs methylate histone lysines	31	7.74e-01	-2.99e-02	8.74e-01
Fatty acid metabolism	104	6.02e-01	2.97e-02	7.56e-01
Constitutive Signaling by AKT1 E17K in Cancer	23	8.09e-01	2.91e-02	8.99e-01
RND3 GTPase cycle	29	7.88e-01	-2.89e-02	8.83e-01
RND1 GTPase cycle	29	7.96e-01	-2.78e-02	8.86e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	8.68e-01	-2.78e-02	9.29e-01
RHOC GTPase cycle	49	7.46e-01	2.68e-02	8.58e-01
Interleukin-37 signaling	17	8.49e-01	2.66e-02	9.18e-01
Carboxyterminal post-translational modifications of tubulin	24	8.22e-01	-2.65e-02	9.07e-01
G alpha (12/13) signalling events	40	7.75e-01	2.61e-02	8.74e-01
Ca-dependent events	21	8.36e-01	2.61e-02	9.10e-01
Adrenaline,noradrenaline inhibits insulin secretion	15	8.64e-01	-2.56e-02	9.26e-01
Effects of PIP2 hydrolysis	19	8.47e-01	-2.55e-02	9.18e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	19	8.48e-01	-2.54e-02	9.18e-01
G alpha (i) signalling events	93	6.73e-01	2.53e-02	8.02e-01
EPH-ephrin mediated repulsion of cells	25	8.28e-01	-2.51e-02	9.07e-01
Peptide ligand-binding receptors	20	8.47e-01	2.50e-02	9.18e-01
Transport of small molecules	359	4.20e-01	-2.49e-02	6.10e-01
Iron uptake and transport	38	7.92e-01	2.47e-02	8.85e-01
Metabolism of folate and pterines	11	8.89e-01	2.42e-02	9.43e-01
Leishmania infection	112	6.67e-01	-2.36e-02	8.01e-01
Amino acids regulate mTORC1	42	7.94e-01	2.33e-02	8.86e-01
TNFR1-induced proapoptotic signaling	12	8.90e-01	-2.30e-02	9.44e-01
Biological oxidations	79	7.28e-01	-2.26e-02	8.42e-01
Processing of Intronless Pre-mRNAs	15	8.81e-01	2.24e-02	9.37e-01
FOXO-mediated transcription	46	7.95e-01	-2.21e-02	8.86e-01
Early Phase of HIV Life Cycle	13	8.93e-01	2.15e-02	9.46e-01
Protein-protein interactions at synapses	33	8.31e-01	-2.14e-02	9.08e-01
G beta:gamma signalling through CDC42	13	8.94e-01	-2.13e-02	9.46e-01
Regulation of insulin secretion	40	8.16e-01	-2.12e-02	9.06e-01
Ion channel transport	80	7.45e-01	-2.10e-02	8.58e-01
Negative regulation of the PI3K/AKT network	56	7.86e-01	-2.10e-02	8.83e-01
CD28 dependent PI3K/Akt signaling	18	8.82e-01	-2.03e-02	9.37e-01
Interleukin-35 Signalling	11	9.08e-01	2.01e-02	9.57e-01
Cardiac conduction	43	8.24e-01	1.96e-02	9.07e-01
RAB geranylgeranylation	40	8.31e-01	1.95e-02	9.08e-01
Post-translational modification: synthesis of GPI-anchored proteins	31	8.54e-01	-1.91e-02	9.19e-01
Golgi Associated Vesicle Biogenesis	38	8.39e-01	-1.91e-02	9.12e-01
Platelet homeostasis	49	8.20e-01	-1.88e-02	9.06e-01
Interleukin receptor SHC signaling	15	9.01e-01	1.85e-02	9.52e-01
Metabolism of lipids	439	5.12e-01	-1.84e-02	6.81e-01
RHOV GTPase cycle	28	8.66e-01	-1.84e-02	9.28e-01
Interleukin-12 signaling	36	8.50e-01	-1.82e-02	9.18e-01
HCMV Late Events	51	8.28e-01	-1.76e-02	9.07e-01
Metabolism of steroid hormones	13	9.13e-01	-1.75e-02	9.59e-01
mRNA 3’-end processing	37	8.54e-01	1.75e-02	9.19e-01
TBC/RABGAPs	40	8.49e-01	-1.74e-02	9.18e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	88	7.78e-01	1.74e-02	8.77e-01
Purine catabolism	10	9.25e-01	1.72e-02	9.65e-01
Post-chaperonin tubulin folding pathway	13	9.17e-01	1.68e-02	9.60e-01
O-linked glycosylation	42	8.51e-01	-1.67e-02	9.18e-01
Keratan sulfate biosynthesis	14	9.15e-01	-1.65e-02	9.60e-01
Regulation of BACH1 activity	11	9.26e-01	-1.61e-02	9.65e-01
Formation of the Early Elongation Complex	30	8.79e-01	-1.60e-02	9.37e-01
Formation of the HIV-1 Early Elongation Complex	30	8.79e-01	-1.60e-02	9.37e-01
Signaling by PDGFR in disease	15	9.15e-01	1.59e-02	9.60e-01
Costimulation by the CD28 family	44	8.62e-01	-1.52e-02	9.25e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	9.28e-01	1.51e-02	9.65e-01
Sphingolipid metabolism	49	8.56e-01	1.50e-02	9.20e-01
Depolymerisation of the Nuclear Lamina	13	9.26e-01	-1.48e-02	9.65e-01
TP53 Regulates Metabolic Genes	71	8.33e-01	-1.44e-02	9.10e-01
RHOF GTPase cycle	25	9.01e-01	1.44e-02	9.52e-01
Nicotinamide salvaging	11	9.35e-01	1.42e-02	9.68e-01
Cell death signalling via NRAGE, NRIF and NADE	45	8.70e-01	-1.41e-02	9.30e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	14	9.27e-01	1.41e-02	9.65e-01
Signaling by NTRK2 (TRKB)	15	9.26e-01	1.39e-02	9.65e-01
Nicotinate metabolism	19	9.17e-01	1.39e-02	9.60e-01
NOD1/2 Signaling Pathway	23	9.10e-01	-1.37e-02	9.58e-01
FGFR2 alternative splicing	22	9.12e-01	-1.35e-02	9.59e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	45	8.82e-01	1.28e-02	9.37e-01
Heme signaling	26	9.10e-01	1.28e-02	9.58e-01
RAC2 GTPase cycle	56	8.73e-01	-1.23e-02	9.32e-01
Sensory Perception	68	8.70e-01	1.15e-02	9.30e-01
Thrombin signalling through proteinase activated receptors (PARs)	20	9.31e-01	-1.12e-02	9.67e-01
E3 ubiquitin ligases ubiquitinate target proteins	41	9.06e-01	-1.06e-02	9.56e-01
Regulation of innate immune responses to cytosolic DNA	12	9.52e-01	-9.99e-03	9.76e-01
Nucleotide catabolism	21	9.37e-01	9.99e-03	9.69e-01
RHOD GTPase cycle	36	9.21e-01	-9.54e-03	9.64e-01
Regulation of TP53 Activity through Acetylation	27	9.32e-01	-9.45e-03	9.68e-01
Signaling by FGFR2 IIIa TM	15	9.50e-01	9.40e-03	9.75e-01
Drug ADME	27	9.33e-01	-9.30e-03	9.68e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	22	9.44e-01	8.67e-03	9.75e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	14	9.56e-01	-8.54e-03	9.79e-01
RAF-independent MAPK1/3 activation	20	9.49e-01	-8.33e-03	9.75e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	23	9.49e-01	-7.77e-03	9.75e-01
Degradation of cysteine and homocysteine	10	9.67e-01	-7.57e-03	9.87e-01
RHOG GTPase cycle	49	9.28e-01	7.44e-03	9.65e-01
Fatty acyl-CoA biosynthesis	26	9.50e-01	7.14e-03	9.75e-01
G beta:gamma signalling through PLC beta	13	9.66e-01	6.81e-03	9.87e-01
Presynaptic function of Kainate receptors	13	9.66e-01	6.81e-03	9.87e-01
Regulation of KIT signaling	10	9.72e-01	-6.35e-03	9.88e-01
RAB GEFs exchange GTP for GDP on RABs	64	9.34e-01	5.97e-03	9.68e-01
Interleukin-12 family signaling	42	9.48e-01	-5.81e-03	9.75e-01
Defective pyroptosis	10	9.76e-01	-5.54e-03	9.88e-01
Interleukin-17 signaling	52	9.45e-01	-5.53e-03	9.75e-01
PIWI-interacting RNA (piRNA) biogenesis	16	9.70e-01	5.50e-03	9.88e-01
Protein ubiquitination	59	9.45e-01	5.24e-03	9.75e-01
Interleukin-4 and Interleukin-13 signaling	49	9.50e-01	5.19e-03	9.75e-01
RHOH GTPase cycle	29	9.62e-01	5.16e-03	9.84e-01
Neutrophil degranulation	307	8.81e-01	-5.01e-03	9.37e-01
Thromboxane signalling through TP receptor	15	9.74e-01	4.81e-03	9.88e-01
G-protein activation	13	9.76e-01	4.72e-03	9.88e-01
CTLA4 inhibitory signaling	16	9.74e-01	-4.70e-03	9.88e-01
VEGFR2 mediated vascular permeability	21	9.70e-01	4.69e-03	9.88e-01
RUNX2 regulates bone development	18	9.73e-01	4.68e-03	9.88e-01
Non-integrin membrane-ECM interactions	14	9.76e-01	-4.57e-03	9.88e-01
Gluconeogenesis	24	9.72e-01	-4.10e-03	9.88e-01
Glycerophospholipid biosynthesis	74	9.53e-01	-3.97e-03	9.76e-01
VEGFR2 mediated cell proliferation	16	9.81e-01	-3.38e-03	9.92e-01
Regulation of beta-cell development	16	9.88e-01	-2.24e-03	9.98e-01
Triglyceride catabolism	11	9.90e-01	2.17e-03	9.98e-01
Insulin processing	17	9.90e-01	-1.84e-03	9.98e-01
Regulation of PTEN mRNA translation	11	9.93e-01	1.46e-03	9.98e-01
Keratan sulfate/keratin metabolism	18	9.93e-01	-1.19e-03	9.98e-01
Diseases of carbohydrate metabolism	23	9.94e-01	-9.76e-04	9.98e-01
ADP signalling through P2Y purinoceptor 12	13	9.95e-01	9.74e-04	9.98e-01
Pyroptosis	18	9.95e-01	-8.71e-04	9.98e-01
Synthesis of PIPs at the early endosome membrane	12	9.97e-01	-7.08e-04	9.98e-01
Synthesis of PIPs at the plasma membrane	36	9.94e-01	6.77e-04	9.98e-01
Pre-NOTCH Expression and Processing	46	9.95e-01	-4.92e-04	9.98e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	20	1.00e+00	5.84e-05	1.00e+00
Neurodegenerative Diseases	20	1.00e+00	5.84e-05	1.00e+00

---

Detailed Gene set reports

Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes

	164
set	Condensation of Prometaphase Chromosomes
setSize	10
pANOVA	0.00289
s.dist	-0.544
p.adjustANOVA	0.021

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCAPD2	-10032.5
CSNK2B	-9702.5
CCNB2	-9599.5
SMC2	-9536.5
CDK1	-9335.5
SMC4	-8209.5
NCAPG	-7088.0
CSNK2A2	-6990.5
CCNB1	-1966.5
NCAPH	-1008.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCAPD2	-10032.5
CSNK2B	-9702.5
CCNB2	-9599.5
SMC2	-9536.5
CDK1	-9335.5
SMC4	-8209.5
NCAPG	-7088.0
CSNK2A2	-6990.5
CCNB1	-1966.5
NCAPH	-1008.5

---

HDR through MMEJ (alt-NHEJ)

HDR through MMEJ (alt-NHEJ)

	405
set	HDR through MMEJ (alt-NHEJ)
setSize	11
pANOVA	0.00204
s.dist	-0.537
p.adjustANOVA	0.0181

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLQ	-9768.5
PARP2	-9231.5
RAD52	-8910.5
XRCC1	-8524.5
RBBP8	-8435.5
FEN1	-7907.5
LIG3	-6824.5
BRCA2	-5847.5
PARP1	-5803.5
NBN	-5346.5
RAD50	-3747.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLQ	-9768.5
PARP2	-9231.5
RAD52	-8910.5
XRCC1	-8524.5
RBBP8	-8435.5
FEN1	-7907.5
LIG3	-6824.5
BRCA2	-5847.5
PARP1	-5803.5
NBN	-5346.5
RAD50	-3747.5

---

NOTCH2 Activation and Transmission of Signal to the Nucleus

NOTCH2 Activation and Transmission of Signal to the Nucleus

	600
set	NOTCH2 Activation and Transmission of Signal to the Nucleus
setSize	12
pANOVA	0.0014
s.dist	-0.532
p.adjustANOVA	0.014

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-9845.5
PSENEN	-9683.0
APH1A	-9523.5
APH1B	-9044.5
UBC	-8335.5
ADAM10	-8323.5
UBA52	-7829.5
MIB1	-6705.5
UBB	-5890.5
NCSTN	-4981.0
PSEN1	-4874.5
PSEN2	-2301.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-9845.5
PSENEN	-9683.0
APH1A	-9523.5
APH1B	-9044.5
UBC	-8335.5
ADAM10	-8323.5
UBA52	-7829.5
MIB1	-6705.5
UBB	-5890.5
NCSTN	-4981.0
PSEN1	-4874.5
PSEN2	-2301.5

---

p75NTR signals via NF-kB

p75NTR signals via NF-kB

	1193
set	p75NTR signals via NF-kB
setSize	11
pANOVA	0.00389
s.dist	-0.502
p.adjustANOVA	0.0258

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-9845.5
IKBKB	-9462.5
PRKCI	-9244.5
MYD88	-8834.5
UBC	-8335.5
UBA52	-7829.5
SQSTM1	-7107.5
NFKBIA	-6897.5
UBB	-5890.5
RELA	-5735.5
TRAF6	1097.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-9845.5
IKBKB	-9462.5
PRKCI	-9244.5
MYD88	-8834.5
UBC	-8335.5
UBA52	-7829.5
SQSTM1	-7107.5
NFKBIA	-6897.5
UBB	-5890.5
RELA	-5735.5
TRAF6	1097.5

---

VLDLR internalisation and degradation

VLDLR internalisation and degradation

	1162
set	VLDLR internalisation and degradation
setSize	11
pANOVA	0.0057
s.dist	-0.481
p.adjustANOVA	0.0337

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-9845.5
NR1H3	-9568.5
MYLIP	-8917.5
UBC	-8335.5
CLTA	-8299.5
AP2A1	-8060.5
UBA52	-7829.5
NR1H2	-6679.5
UBB	-5890.5
AP2S1	-4086.5
AP2M1	829.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-9845.5
NR1H3	-9568.5
MYLIP	-8917.5
UBC	-8335.5
CLTA	-8299.5
AP2A1	-8060.5
UBA52	-7829.5
NR1H2	-6679.5
UBB	-5890.5
AP2S1	-4086.5
AP2M1	829.5

---

SARS-CoV-2 modulates autophagy

SARS-CoV-2 modulates autophagy

	900
set	SARS-CoV-2 modulates autophagy
setSize	11
pANOVA	0.00655
s.dist	-0.473
p.adjustANOVA	0.0363

Top enriched genes

Top 20 genes

GeneID	Gene Rank
VPS45	-9955.5
VPS33B	-8498.5
UVRAG	-8193.5
VPS18	-7791.5
VPS11	-7554.5
VPS39	-7205.5
TUFM	-6919.5
VPS41	-6475.5
VPS33A	-6251.5
MAP1LC3B	-4494.5
VPS16	-2817.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
VPS45	-9955.5
VPS33B	-8498.5
UVRAG	-8193.5
VPS18	-7791.5
VPS11	-7554.5
VPS39	-7205.5
TUFM	-6919.5
VPS41	-6475.5
VPS33A	-6251.5
MAP1LC3B	-4494.5
VPS16	-2817.5

---

RHO GTPases Activate ROCKs

RHO GTPases Activate ROCKs

	764
set	RHO GTPases Activate ROCKs
setSize	13
pANOVA	0.00408
s.dist	-0.46
p.adjustANOVA	0.0267

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RHOA	-9322.0
CFL1	-9205.5
MYL6	-9081.5
MYH10	-9072.5
MYH9	-7785.5
RHOB	-7665.5
PPP1CB	-7568.5
ROCK1	-6350.5
PAK1	-5418.5
PPP1R12A	-5139.5
PPP1R12B	-4449.5
LIMK2	-4096.5
LIMK1	-3795.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RHOA	-9322.0
CFL1	-9205.5
MYL6	-9081.5
MYH10	-9072.5
MYH9	-7785.5
RHOB	-7665.5
PPP1CB	-7568.5
ROCK1	-6350.5
PAK1	-5418.5
PPP1R12A	-5139.5
PPP1R12B	-4449.5
LIMK2	-4096.5
LIMK1	-3795.5

---

RIPK1-mediated regulated necrosis

RIPK1-mediated regulated necrosis

	784
set	RIPK1-mediated regulated necrosis
setSize	25
pANOVA	8.38e-05
s.dist	-0.454
p.adjustANOVA	0.00198

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CFLAR	-10082.5
CASP8	-10073.5
PDCD6IP	-9993.5
RPS27A	-9845.5
RIPK3	-9785.5
TNFRSF10B	-9339.5
PELI1	-9120.5
UBC	-8335.5
FAS	-8198.0
TRAF2	-8182.5
UBA52	-7829.5
CDC37	-7681.0
HSP90AA1	-7192.5
FLOT1	-7039.5
BIRC3	-6746.5
FLOT2	-6165.5
BIRC2	-6098.5
STUB1	-6073.5
UBB	-5890.5
TNFSF10	-5850.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CFLAR	-10082.5
CASP8	-10073.5
PDCD6IP	-9993.5
RPS27A	-9845.5
RIPK3	-9785.5
TNFRSF10B	-9339.5
PELI1	-9120.5
UBC	-8335.5
FAS	-8198.0
TRAF2	-8182.5
UBA52	-7829.5
CDC37	-7681.0
HSP90AA1	-7192.5
FLOT1	-7039.5
BIRC3	-6746.5
FLOT2	-6165.5
BIRC2	-6098.5
STUB1	-6073.5
UBB	-5890.5
TNFSF10	-5850.5
TRADD	-5100.0
MLKL	-3839.5
TNFRSF10A	-2126.5
FADD	-994.5
SDCBP	1421.5

---

Regulation of necroptotic cell death

Regulation of necroptotic cell death

	870
set	Regulation of necroptotic cell death
setSize	25
pANOVA	8.38e-05
s.dist	-0.454
p.adjustANOVA	0.00198

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CFLAR	-10082.5
CASP8	-10073.5
PDCD6IP	-9993.5
RPS27A	-9845.5
RIPK3	-9785.5
TNFRSF10B	-9339.5
PELI1	-9120.5
UBC	-8335.5
FAS	-8198.0
TRAF2	-8182.5
UBA52	-7829.5
CDC37	-7681.0
HSP90AA1	-7192.5
FLOT1	-7039.5
BIRC3	-6746.5
FLOT2	-6165.5
BIRC2	-6098.5
STUB1	-6073.5
UBB	-5890.5
TNFSF10	-5850.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CFLAR	-10082.5
CASP8	-10073.5
PDCD6IP	-9993.5
RPS27A	-9845.5
RIPK3	-9785.5
TNFRSF10B	-9339.5
PELI1	-9120.5
UBC	-8335.5
FAS	-8198.0
TRAF2	-8182.5
UBA52	-7829.5
CDC37	-7681.0
HSP90AA1	-7192.5
FLOT1	-7039.5
BIRC3	-6746.5
FLOT2	-6165.5
BIRC2	-6098.5
STUB1	-6073.5
UBB	-5890.5
TNFSF10	-5850.5
TRADD	-5100.0
MLKL	-3839.5
TNFRSF10A	-2126.5
FADD	-994.5
SDCBP	1421.5

---

Voltage gated Potassium channels

Voltage gated Potassium channels

	1170
set	Voltage gated Potassium channels
setSize	13
pANOVA	0.0059
s.dist	0.441
p.adjustANOVA	0.0346

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KCNC3	1650.5
KCNQ5	979.5
KCNA6	0.5
KCNH2	0.5
KCNQ4	-857.5
KCNQ1	-1019.0
KCNG3	-1287.5
KCNAB2	-1673.5
KCNC4	-1845.5
KCNA3	-2005.5
KCNS1	-2406.5
KCNH4	-5017.5
KCNA2	-5228.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KCNC3	1650.5
KCNQ5	979.5
KCNA6	0.5
KCNH2	0.5
KCNQ4	-857.5
KCNQ1	-1019.0
KCNG3	-1287.5
KCNAB2	-1673.5
KCNC4	-1845.5
KCNA3	-2005.5
KCNS1	-2406.5
KCNH4	-5017.5
KCNA2	-5228.5

---

Negative regulation of FLT3

Negative regulation of FLT3

	616
set	Negative regulation of FLT3
setSize	13
pANOVA	0.00651
s.dist	-0.436
p.adjustANOVA	0.0363

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-9845.5
SLA2	-9770.5
SLA	-9754.0
SH2B3	-9084.5
UBC	-8335.5
CSK	-8254.5
UBA52	-7829.5
UBB	-5890.5
FLT3LG	-5813.5
ABL2	-5439.5
CBL	-4657.5
SOCS2	-2391.5
PTPRJ	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-9845.5
SLA2	-9770.5
SLA	-9754.0
SH2B3	-9084.5
UBC	-8335.5
CSK	-8254.5
UBA52	-7829.5
UBB	-5890.5
FLT3LG	-5813.5
ABL2	-5439.5
CBL	-4657.5
SOCS2	-2391.5
PTPRJ	0.5

---

Signaling by NOTCH2

Signaling by NOTCH2

	993
set	Signaling by NOTCH2
setSize	18
pANOVA	0.00144
s.dist	-0.433
p.adjustANOVA	0.014

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RBPJ	-10048.5
RPS27A	-9845.5
PSENEN	-9683.0
APH1A	-9523.5
MAML2	-9152.5
APH1B	-9044.5
UBC	-8335.5
ADAM10	-8323.5
UBA52	-7829.5
MIB1	-6705.5
CREB1	-6241.5
UBB	-5890.5
MAML1	-5408.5
NCSTN	-4981.0
PSEN1	-4874.5
PSEN2	-2301.5
EP300	-1424.5
MAML3	-691.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RBPJ	-10048.5
RPS27A	-9845.5
PSENEN	-9683.0
APH1A	-9523.5
MAML2	-9152.5
APH1B	-9044.5
UBC	-8335.5
ADAM10	-8323.5
UBA52	-7829.5
MIB1	-6705.5
CREB1	-6241.5
UBB	-5890.5
MAML1	-5408.5
NCSTN	-4981.0
PSEN1	-4874.5
PSEN2	-2301.5
EP300	-1424.5
MAML3	-691.5

---

Meiotic recombination

Meiotic recombination

	533
set	Meiotic recombination
setSize	19
pANOVA	0.00112
s.dist	-0.432
p.adjustANOVA	0.0121

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATM	-10077.0
PSMC3IP	-9776.5
BRCA1	-9585.0
DMC1	-9489.5
MLH3	-8914.5
RBBP8	-8435.5
TOP3A	-8205.0
CDK4	-7355.5
RPA1	-7258.0
RAD51	-6975.5
MND1	-6910.5
RPA3	-6476.5
BRCA2	-5847.5
MSH5	-5697.5
NBN	-5346.5
RAD50	-3747.5
CDK2	-2911.5
BLM	-2156.5
H2AFX	-1621.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATM	-10077.0
PSMC3IP	-9776.5
BRCA1	-9585.0
DMC1	-9489.5
MLH3	-8914.5
RBBP8	-8435.5
TOP3A	-8205.0
CDK4	-7355.5
RPA1	-7258.0
RAD51	-6975.5
MND1	-6910.5
RPA3	-6476.5
BRCA2	-5847.5
MSH5	-5697.5
NBN	-5346.5
RAD50	-3747.5
CDK2	-2911.5
BLM	-2156.5
H2AFX	-1621.5

---

Caspase activation via Death Receptors in the presence of ligand

Caspase activation via Death Receptors in the presence of ligand

	120
set	Caspase activation via Death Receptors in the presence of ligand
setSize	10
pANOVA	0.0181
s.dist	-0.431
p.adjustANOVA	0.074

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CFLAR	-10082.5
CASP8	-10073.5
TNFRSF10B	-9339.5
FAS	-8198.0
TRAF2	-8182.5
TICAM1	-6782.5
TNFSF10	-5850.5
TRADD	-5100.0
TNFRSF10A	-2126.5
FADD	-994.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CFLAR	-10082.5
CASP8	-10073.5
TNFRSF10B	-9339.5
FAS	-8198.0
TRAF2	-8182.5
TICAM1	-6782.5
TNFSF10	-5850.5
TRADD	-5100.0
TNFRSF10A	-2126.5
FADD	-994.5

---

Glyoxylate metabolism and glycine degradation

Glyoxylate metabolism and glycine degradation

	392
set	Glyoxylate metabolism and glycine degradation
setSize	19
pANOVA	0.00139
s.dist	-0.423
p.adjustANOVA	0.014

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LIAS	-9871.0
OGDH	-9729.5
ALDH4A1	-9531.5
DBT	-9474.5
DHTKD1	-9285.5
NDUFAB1	-9153.5
BCKDHA	-8898.0
PDHB	-8582.5
DLST	-8391.5
BCKDHB	-8369.5
LIPT1	-6558.5
GOT2	-5789.5
DLD	-5416.5
PXMP2	-4994.0
LIPT2	-4509.5
DLAT	-4470.5
PDHX	-1946.0
GRHPR	-1619.5
GCSH	749.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LIAS	-9871.0
OGDH	-9729.5
ALDH4A1	-9531.5
DBT	-9474.5
DHTKD1	-9285.5
NDUFAB1	-9153.5
BCKDHA	-8898.0
PDHB	-8582.5
DLST	-8391.5
BCKDHB	-8369.5
LIPT1	-6558.5
GOT2	-5789.5
DLD	-5416.5
PXMP2	-4994.0
LIPT2	-4509.5
DLAT	-4470.5
PDHX	-1946.0
GRHPR	-1619.5
GCSH	749.0

---

NOTCH3 Activation and Transmission of Signal to the Nucleus

NOTCH3 Activation and Transmission of Signal to the Nucleus

	601
set	NOTCH3 Activation and Transmission of Signal to the Nucleus
setSize	15
pANOVA	0.00519
s.dist	-0.417
p.adjustANOVA	0.0315

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-9845.5
PSENEN	-9683.0
APH1A	-9523.5
APH1B	-9044.5
UBC	-8335.5
ADAM10	-8323.5
UBA52	-7829.5
MIB1	-6705.5
UBB	-5890.5
YBX1	-5801.5
NCSTN	-4981.0
PSEN1	-4874.5
WWP2	-4004.5
PSEN2	-2301.5
TACC3	-1598.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-9845.5
PSENEN	-9683.0
APH1A	-9523.5
APH1B	-9044.5
UBC	-8335.5
ADAM10	-8323.5
UBA52	-7829.5
MIB1	-6705.5
UBB	-5890.5
YBX1	-5801.5
NCSTN	-4981.0
PSEN1	-4874.5
WWP2	-4004.5
PSEN2	-2301.5
TACC3	-1598.5

---

CTNNB1 S33 mutants aren’t phosphorylated

CTNNB1 S33 mutants aren’t phosphorylated

	105
set	CTNNB1 S33 mutants aren’t phosphorylated
setSize	13
pANOVA	0.0103
s.dist	-0.411
p.adjustANOVA	0.0493

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

CTNNB1 S37 mutants aren’t phosphorylated

CTNNB1 S37 mutants aren’t phosphorylated

	106
set	CTNNB1 S37 mutants aren’t phosphorylated
setSize	13
pANOVA	0.0103
s.dist	-0.411
p.adjustANOVA	0.0493

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

CTNNB1 S45 mutants aren’t phosphorylated

CTNNB1 S45 mutants aren’t phosphorylated

	107
set	CTNNB1 S45 mutants aren’t phosphorylated
setSize	13
pANOVA	0.0103
s.dist	-0.411
p.adjustANOVA	0.0493

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

CTNNB1 T41 mutants aren’t phosphorylated

CTNNB1 T41 mutants aren’t phosphorylated

	108
set	CTNNB1 T41 mutants aren’t phosphorylated
setSize	13
pANOVA	0.0103
s.dist	-0.411
p.adjustANOVA	0.0493

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

Signaling by CTNNB1 phospho-site mutants

Signaling by CTNNB1 phospho-site mutants

	955
set	Signaling by CTNNB1 phospho-site mutants
setSize	13
pANOVA	0.0103
s.dist	-0.411
p.adjustANOVA	0.0493

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

Signaling by GSK3beta mutants

Signaling by GSK3beta mutants

	978
set	Signaling by GSK3beta mutants
setSize	13
pANOVA	0.0103
s.dist	-0.411
p.adjustANOVA	0.0493

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization

	394
set	Golgi Cisternae Pericentriolar Stack Reorganization
setSize	14
pANOVA	0.00795
s.dist	-0.41
p.adjustANOVA	0.0417

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RAB1B	-9981.5
CCNB2	-9599.5
MAPK3	-9428.5
CDK1	-9335.5
BLZF1	-9271.0
USO1	-9015.5
RAB1A	-8106.5
PLK1	-7634.5
MAPK1	-7492.5
GOLGA2	-4678.5
GORASP2	-3470.5
RAB2A	-2452.5
CCNB1	-1966.5
GORASP1	863.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RAB1B	-9981.5
CCNB2	-9599.5
MAPK3	-9428.5
CDK1	-9335.5
BLZF1	-9271.0
USO1	-9015.5
RAB1A	-8106.5
PLK1	-7634.5
MAPK1	-7492.5
GOLGA2	-4678.5
GORASP2	-3470.5
RAB2A	-2452.5
CCNB1	-1966.5
GORASP1	863.0

---

Defects in vitamin and cofactor metabolism

Defects in vitamin and cofactor metabolism

	217
set	Defects in vitamin and cofactor metabolism
setSize	16
pANOVA	0.00594
s.dist	-0.397
p.adjustANOVA	0.0346

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCCC1	-9827.5
LMBRD1	-9329.5
CD320	-8481.5
BTD	-8120.0
MMAA	-7852.5
MMACHC	-7488.0
MMADHC	-7119.5
MTRR	-7118.5
ACACA	-7071.5
MTR	-6157.5
HLCS	-5516.5
MMAB	-5184.0
PC	-4793.5
ABCD4	-3833.5
MCCC2	-3832.5
PCCB	-1725.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCCC1	-9827.5
LMBRD1	-9329.5
CD320	-8481.5
BTD	-8120.0
MMAA	-7852.5
MMACHC	-7488.0
MMADHC	-7119.5
MTRR	-7118.5
ACACA	-7071.5
MTR	-6157.5
HLCS	-5516.5
MMAB	-5184.0
PC	-4793.5
ABCD4	-3833.5
MCCC2	-3832.5
PCCB	-1725.5

---

APC truncation mutants have impaired AXIN binding

APC truncation mutants have impaired AXIN binding

	9
set	APC truncation mutants have impaired AXIN binding
setSize	12
pANOVA	0.0209
s.dist	-0.385
p.adjustANOVA	0.0809

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

AXIN missense mutants destabilize the destruction complex

AXIN missense mutants destabilize the destruction complex

	20
set	AXIN missense mutants destabilize the destruction complex
setSize	12
pANOVA	0.0209
s.dist	-0.385
p.adjustANOVA	0.0809

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

Signaling by AMER1 mutants

Signaling by AMER1 mutants

	948
set	Signaling by AMER1 mutants
setSize	12
pANOVA	0.0209
s.dist	-0.385
p.adjustANOVA	0.0809

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

Signaling by APC mutants

Signaling by APC mutants

	949
set	Signaling by APC mutants
setSize	12
pANOVA	0.0209
s.dist	-0.385
p.adjustANOVA	0.0809

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

Signaling by AXIN mutants

Signaling by AXIN mutants

	950
set	Signaling by AXIN mutants
setSize	12
pANOVA	0.0209
s.dist	-0.385
p.adjustANOVA	0.0809

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

Truncations of AMER1 destabilize the destruction complex

Truncations of AMER1 destabilize the destruction complex

	1151
set	Truncations of AMER1 destabilize the destruction complex
setSize	12
pANOVA	0.0209
s.dist	-0.385
p.adjustANOVA	0.0809

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

NRIF signals cell death from the nucleus

NRIF signals cell death from the nucleus

	607
set	NRIF signals cell death from the nucleus
setSize	14
pANOVA	0.0128
s.dist	-0.384
p.adjustANOVA	0.058

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-9845.5
PSENEN	-9683.0
APH1A	-9523.5
APH1B	-9044.5
ITGB3BP	-8926.0
UBC	-8335.5
UBA52	-7829.5
SQSTM1	-7107.5
UBB	-5890.5
NCSTN	-4981.0
PSEN1	-4874.5
PSEN2	-2301.5
MAPK8	-2204.5
TRAF6	1097.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-9845.5
PSENEN	-9683.0
APH1A	-9523.5
APH1B	-9044.5
ITGB3BP	-8926.0
UBC	-8335.5
UBA52	-7829.5
SQSTM1	-7107.5
UBB	-5890.5
NCSTN	-4981.0
PSEN1	-4874.5
PSEN2	-2301.5
MAPK8	-2204.5
TRAF6	1097.5

---

Glycogen storage diseases

Glycogen storage diseases

	387
set	Glycogen storage diseases
setSize	10
pANOVA	0.0364
s.dist	-0.382
p.adjustANOVA	0.124

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-9845.5
G6PC3	-9701.5
UBC	-8335.5
GYG1	-8027.5
UBA52	-7829.5
GAA	-7392.5
UBB	-5890.5
SLC37A4	-5112.5
NHLRC1	-927.5
GYS1	-696.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-9845.5
G6PC3	-9701.5
UBC	-8335.5
GYG1	-8027.5
UBA52	-7829.5
GAA	-7392.5
UBB	-5890.5
SLC37A4	-5112.5
NHLRC1	-927.5
GYS1	-696.0

---

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

	911
set	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
setSize	27
pANOVA	0.000633
s.dist	-0.38
p.adjustANOVA	0.00746

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TGIF1	-10051.5
RPS27A	-9845.5
MAPK3	-9428.5
SP1	-9348.5
CDK9	-8955.5
E2F5	-8756.5
SMAD3	-8709.5
RNF111	-8523.5
UBC	-8335.5
CCNT1	-8326.5
HDAC1	-8140.5
RBL1	-7894.5
CDK8	-7873.5
UBA52	-7829.5
MAPK1	-7492.5
TFDP1	-7186.5
MEN1	-7106.5
JUNB	-6862.5
CCNC	-6793.5
UBB	-5890.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TGIF1	-10051.5
RPS27A	-9845.5
MAPK3	-9428.5
SP1	-9348.5
CDK9	-8955.5
E2F5	-8756.5
SMAD3	-8709.5
RNF111	-8523.5
UBC	-8335.5
CCNT1	-8326.5
HDAC1	-8140.5
RBL1	-7894.5
CDK8	-7873.5
UBA52	-7829.5
MAPK1	-7492.5
TFDP1	-7186.5
MEN1	-7106.5
JUNB	-6862.5
CCNC	-6793.5
UBB	-5890.5
TFDP2	-5086.5
SMAD7	-3220.5
CCNK	-1393.0
E2F4	-1094.5
SMAD4	0.5
TGIF2	1048.5
SMAD2	1377.5

---

Gap-filling DNA repair synthesis and ligation in GG-NER

Gap-filling DNA repair synthesis and ligation in GG-NER

	368
set	Gap-filling DNA repair synthesis and ligation in GG-NER
setSize	23
pANOVA	0.00165
s.dist	-0.379
p.adjustANOVA	0.0154

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLK	-9952.0
RPS27A	-9845.5
RFC5	-9018.5
XRCC1	-8524.5
UBC	-8335.5
POLE2	-8076.5
POLD3	-7834.5
UBA52	-7829.5
RFC3	-7644.5
POLD4	-7616.5
POLE3	-7383.0
RPA1	-7258.0
LIG3	-6824.5
RFC4	-6563.5
RPA3	-6476.5
POLD2	-6072.5
UBB	-5890.5
POLE	-4994.0
RFC2	-4130.5
PCNA	-3925.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLK	-9952.0
RPS27A	-9845.5
RFC5	-9018.5
XRCC1	-8524.5
UBC	-8335.5
POLE2	-8076.5
POLD3	-7834.5
UBA52	-7829.5
RFC3	-7644.5
POLD4	-7616.5
POLE3	-7383.0
RPA1	-7258.0
LIG3	-6824.5
RFC4	-6563.5
RPA3	-6476.5
POLD2	-6072.5
UBB	-5890.5
POLE	-4994.0
RFC2	-4130.5
PCNA	-3925.5
POLE4	-3471.5
LIG1	0.5
POLD1	1492.5

---

Translesion synthesis by POLK

Translesion synthesis by POLK

	1131
set	Translesion synthesis by POLK
setSize	15
pANOVA	0.012
s.dist	-0.374
p.adjustANOVA	0.0555

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLK	-9952.0
RPS27A	-9845.5
RFC5	-9018.5
UBC	-8335.5
UBA52	-7829.5
RFC3	-7644.5
RPA1	-7258.0
RFC4	-6563.5
RPA3	-6476.5
MAD2L2	-6213.5
UBB	-5890.5
RFC2	-4130.5
PCNA	-3925.5
REV3L	-1860.5
REV1	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLK	-9952.0
RPS27A	-9845.5
RFC5	-9018.5
UBC	-8335.5
UBA52	-7829.5
RFC3	-7644.5
RPA1	-7258.0
RFC4	-6563.5
RPA3	-6476.5
MAD2L2	-6213.5
UBB	-5890.5
RFC2	-4130.5
PCNA	-3925.5
REV3L	-1860.5
REV1	0.5

---

Impaired BRCA2 binding to RAD51

Impaired BRCA2 binding to RAD51

	438
set	Impaired BRCA2 binding to RAD51
setSize	32
pANOVA	0.000265
s.dist	-0.372
p.adjustANOVA	0.00426

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATM	-10077.0
RAD9B	-9886.0
TOPBP1	-9636.5
BRCA1	-9585.0
RAD17	-9213.0
RFC5	-9018.5
RMI1	-8664.0
RBBP8	-8435.5
TOP3A	-8205.0
ATRIP	-7955.5
ATR	-7840.5
RAD9A	-7827.5
RFC3	-7644.5
BRIP1	-7547.5
RPA1	-7258.0
RAD51	-6975.5
RAD1	-6858.0
RFC4	-6563.5
RPA3	-6476.5
BRCA2	-5847.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATM	-10077.0
RAD9B	-9886.0
TOPBP1	-9636.5
BRCA1	-9585.0
RAD17	-9213.0
RFC5	-9018.5
RMI1	-8664.0
RBBP8	-8435.5
TOP3A	-8205.0
ATRIP	-7955.5
ATR	-7840.5
RAD9A	-7827.5
RFC3	-7644.5
BRIP1	-7547.5
RPA1	-7258.0
RAD51	-6975.5
RAD1	-6858.0
RFC4	-6563.5
RPA3	-6476.5
BRCA2	-5847.5
DNA2	-5765.5
KAT5	-5567.5
NBN	-5346.5
EXO1	-4768.5
RMI2	-4253.5
RFC2	-4130.5
RAD50	-3747.5
RHNO1	-3722.5
HUS1	-2189.5
BLM	-2156.5
BARD1	-670.5
WRN	1750.0

---

HDR through Single Strand Annealing (SSA)

HDR through Single Strand Annealing (SSA)

	406
set	HDR through Single Strand Annealing (SSA)
setSize	35
pANOVA	0.000248
s.dist	-0.358
p.adjustANOVA	0.0042

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATM	-10077.0
RAD9B	-9886.0
TOPBP1	-9636.5
BRCA1	-9585.0
ABL1	-9490.5
RAD17	-9213.0
RFC5	-9018.5
RAD52	-8910.5
RMI1	-8664.0
RBBP8	-8435.5
TOP3A	-8205.0
ATRIP	-7955.5
ATR	-7840.5
RAD9A	-7827.5
RFC3	-7644.5
BRIP1	-7547.5
RPA1	-7258.0
RAD51	-6975.5
RAD1	-6858.0
RFC4	-6563.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATM	-10077.0
RAD9B	-9886.0
TOPBP1	-9636.5
BRCA1	-9585.0
ABL1	-9490.5
RAD17	-9213.0
RFC5	-9018.5
RAD52	-8910.5
RMI1	-8664.0
RBBP8	-8435.5
TOP3A	-8205.0
ATRIP	-7955.5
ATR	-7840.5
RAD9A	-7827.5
RFC3	-7644.5
BRIP1	-7547.5
RPA1	-7258.0
RAD51	-6975.5
RAD1	-6858.0
RFC4	-6563.5
RPA3	-6476.5
DNA2	-5765.5
KAT5	-5567.5
NBN	-5346.5
EXO1	-4768.5
RMI2	-4253.5
RFC2	-4130.5
RAD50	-3747.5
RHNO1	-3722.5
HUS1	-2189.5
BLM	-2156.5
ERCC4	-2116.5
ERCC1	-1185.5
BARD1	-670.5
WRN	1750.0

---

Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade

	83
set	Beta-catenin phosphorylation cascade
setSize	15
pANOVA	0.0166
s.dist	-0.357
p.adjustANOVA	0.0694

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
FRAT1	-6545.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
FRAT2	-1720.5
PPP2R1B	-876.5
PPP2R5C	-768.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-9654.5
PPP2R5D	-9476.5
PPP2CA	-8895.5
PPP2R5E	-8889.5
CTNNB1	-8407.5
AXIN1	-8087.5
PPP2R5A	-7872.5
CSNK1A1	-7759.5
FRAT1	-6545.5
PPP2R5B	-6134.5
PPP2CB	-5145.5
GSK3B	-3166.5
FRAT2	-1720.5
PPP2R1B	-876.5
PPP2R5C	-768.5

---

Cobalamin (Cbl, vitamin B12) transport and metabolism

Cobalamin (Cbl, vitamin B12) transport and metabolism

	158
set	Cobalamin (Cbl, vitamin B12) transport and metabolism
setSize	11
pANOVA	0.0413
s.dist	-0.355
p.adjustANOVA	0.135

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LMBRD1	-9329.5
CD320	-8481.5
MMAA	-7852.5
MMACHC	-7488.0
MMADHC	-7119.5
MTRR	-7118.5
MTR	-6157.5
ABCC1	-5800.5
MMAB	-5184.0
ABCD4	-3833.5
LDLRAP1	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LMBRD1	-9329.5
CD320	-8481.5
MMAA	-7852.5
MMACHC	-7488.0
MMADHC	-7119.5
MTRR	-7118.5
MTR	-6157.5
ABCC1	-5800.5
MMAB	-5184.0
ABCD4	-3833.5
LDLRAP1	0.5

---

mRNA decay by 3’ to 5’ exoribonuclease

mRNA decay by 3’ to 5’ exoribonuclease

	1185
set	mRNA decay by 3’ to 5’ exoribonuclease
setSize	14
pANOVA	0.022
s.dist	-0.353
p.adjustANOVA	0.0841

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DIS3	-9204.0
EXOSC8	-9127.5
EXOSC2	-9064.5
EXOSC5	-8898.0
HBS1L	-8652.5
EXOSC3	-7414.5
EXOSC1	-7176.0
WDR61	-6043.5
TTC37	-5723.0
SKIV2L	-5159.5
EXOSC4	-4159.5
DCPS	-3344.5
EXOSC7	-1547.5
EXOSC6	-1345.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DIS3	-9204.0
EXOSC8	-9127.5
EXOSC2	-9064.5
EXOSC5	-8898.0
HBS1L	-8652.5
EXOSC3	-7414.5
EXOSC1	-7176.0
WDR61	-6043.5
TTC37	-5723.0
SKIV2L	-5159.5
EXOSC4	-4159.5
DCPS	-3344.5
EXOSC7	-1547.5
EXOSC6	-1345.5

---

Glycogen synthesis

Glycogen synthesis

	388
set	Glycogen synthesis
setSize	11
pANOVA	0.0425
s.dist	-0.353
p.adjustANOVA	0.137

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UGP2	-10040.5
RPS27A	-9845.5
UBC	-8335.5
GYG1	-8027.5
UBA52	-7829.5
PGM2L1	-7014.5
PGM2	-6129.5
UBB	-5890.5
PGM1	-3490.5
NHLRC1	-927.5
GYS1	-696.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UGP2	-10040.5
RPS27A	-9845.5
UBC	-8335.5
GYG1	-8027.5
UBA52	-7829.5
PGM2L1	-7014.5
PGM2	-6129.5
UBB	-5890.5
PGM1	-3490.5
NHLRC1	-927.5
GYS1	-696.0

---

APC/C:Cdc20 mediated degradation of Cyclin B

APC/C:Cdc20 mediated degradation of Cyclin B

	12
set	APC/C:Cdc20 mediated degradation of Cyclin B
setSize	22
pANOVA	0.00481
s.dist	-0.347
p.adjustANOVA	0.0299

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ANAPC7	-10044.5
RPS27A	-9845.5
ANAPC10	-9790.0
CDK1	-9335.5
CDC23	-9279.5
ANAPC15	-8853.5
ANAPC1	-8623.5
UBC	-8335.5
UBE2E1	-8329.5
ANAPC16	-8113.5
UBA52	-7829.5
CDC20	-6092.5
ANAPC5	-5955.5
UBB	-5890.5
ANAPC4	-5676.5
ANAPC2	-4120.0
UBE2D1	-3813.5
ANAPC11	-2966.5
CCNB1	-1966.5
UBE2C	-1905.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ANAPC7	-10044.5
RPS27A	-9845.5
ANAPC10	-9790.0
CDK1	-9335.5
CDC23	-9279.5
ANAPC15	-8853.5
ANAPC1	-8623.5
UBC	-8335.5
UBE2E1	-8329.5
ANAPC16	-8113.5
UBA52	-7829.5
CDC20	-6092.5
ANAPC5	-5955.5
UBB	-5890.5
ANAPC4	-5676.5
ANAPC2	-4120.0
UBE2D1	-3813.5
ANAPC11	-2966.5
CCNB1	-1966.5
UBE2C	-1905.5
UBE2S	0.5
CDC16	1131.5

---

Chaperone Mediated Autophagy

Chaperone Mediated Autophagy

	141
set	Chaperone Mediated Autophagy
setSize	12
pANOVA	0.0383
s.dist	-0.345
p.adjustANOVA	0.128

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-9845.5
EEF1A1	-9269.5
HSP90AB1	-8459.5
UBC	-8335.5
UBA52	-7829.5
HSP90AA1	-7192.5
PLIN3	-5913.5
UBB	-5890.5
PARK7	-4903.5
ARL13B	-3530.5
PCNT	-1365.0
PLIN2	-1326.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-9845.5
EEF1A1	-9269.5
HSP90AB1	-8459.5
UBC	-8335.5
UBA52	-7829.5
HSP90AA1	-7192.5
PLIN3	-5913.5
UBB	-5890.5
PARK7	-4903.5
ARL13B	-3530.5
PCNT	-1365.0
PLIN2	-1326.5

---

Translation of Structural Proteins

Translation of Structural Proteins

	1128
set	Translation of Structural Proteins
setSize	27
pANOVA	0.00193
s.dist	-0.345
p.adjustANOVA	0.0174

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PARP9	-9901.0
RPS27A	-9845.5
GSK3A	-9586.5
PRKCSH	-9243.0
MGAT1	-9151.5
ST3GAL1	-9131.5
ST3GAL3	-8855.5
UBC	-8335.5
GANAB	-8154.5
ST6GAL1	-8058.5
UBA52	-7829.5
ST3GAL2	-7454.5
PARP14	-7137.5
ST6GALNAC3	-6674.5
UBB	-5890.5
MOGS	-5695.5
SUMO1	-5641.5
PARP4	-5381.5
UBE2I	-5253.5
PARP10	-4659.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PARP9	-9901.0
RPS27A	-9845.5
GSK3A	-9586.5
PRKCSH	-9243.0
MGAT1	-9151.5
ST3GAL1	-9131.5
ST3GAL3	-8855.5
UBC	-8335.5
GANAB	-8154.5
ST6GAL1	-8058.5
UBA52	-7829.5
ST3GAL2	-7454.5
PARP14	-7137.5
ST6GALNAC3	-6674.5
UBB	-5890.5
MOGS	-5695.5
SUMO1	-5641.5
PARP4	-5381.5
UBE2I	-5253.5
PARP10	-4659.5
PARP16	-4577.5
ST3GAL4	-3816.5
PARP8	-3573.5
GSK3B	-3166.5
ST6GALNAC4	-751.5
CANX	0.5
PARP6	1721.5

---

Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

	169
set	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
setSize	14
pANOVA	0.0257
s.dist	-0.344
p.adjustANOVA	0.0942

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-9845.5
KRAS	-8859.5
SHC1	-8813.0
UBC	-8335.5
UBA52	-7829.5
CDC37	-7681.0
HRAS	-7209.5
HSP90AA1	-7192.5
UBB	-5890.5
PIK3CA	-5753.5
CBL	-4657.5
PLCG1	-2462.5
GRB2	-2220.5
PIK3R1	668.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-9845.5
KRAS	-8859.5
SHC1	-8813.0
UBC	-8335.5
UBA52	-7829.5
CDC37	-7681.0
HRAS	-7209.5
HSP90AA1	-7192.5
UBB	-5890.5
PIK3CA	-5753.5
CBL	-4657.5
PLCG1	-2462.5
GRB2	-2220.5
PIK3R1	668.5

---

Signaling by Ligand-Responsive EGFR Variants in Cancer

Signaling by Ligand-Responsive EGFR Variants in Cancer

	985
set	Signaling by Ligand-Responsive EGFR Variants in Cancer
setSize	14
pANOVA	0.0257
s.dist	-0.344
p.adjustANOVA	0.0942

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-9845.5
KRAS	-8859.5
SHC1	-8813.0
UBC	-8335.5
UBA52	-7829.5
CDC37	-7681.0
HRAS	-7209.5
HSP90AA1	-7192.5
UBB	-5890.5
PIK3CA	-5753.5
CBL	-4657.5
PLCG1	-2462.5
GRB2	-2220.5
PIK3R1	668.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-9845.5
KRAS	-8859.5
SHC1	-8813.0
UBC	-8335.5
UBA52	-7829.5
CDC37	-7681.0
HRAS	-7209.5
HSP90AA1	-7192.5
UBB	-5890.5
PIK3CA	-5753.5
CBL	-4657.5
PLCG1	-2462.5
GRB2	-2220.5
PIK3R1	668.5

---

Spry regulation of FGF signaling

Spry regulation of FGF signaling

	1030
set	Spry regulation of FGF signaling
setSize	15
pANOVA	0.0217
s.dist	-0.342
p.adjustANOVA	0.0835

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SPRY2	-9909.5
RPS27A	-9845.5
MAPK3	-9428.5
PPP2CA	-8895.5
UBC	-8335.5
UBA52	-7829.5
MAPK1	-7492.5
MKNK1	-7474.5
UBB	-5890.5
PPP2CB	-5145.5
BRAF	-4674.5
CBL	-4657.5
GRB2	-2220.5
PTPN11	-1453.5
SRC	1212.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SPRY2	-9909.5
RPS27A	-9845.5
MAPK3	-9428.5
PPP2CA	-8895.5
UBC	-8335.5
UBA52	-7829.5
MAPK1	-7492.5
MKNK1	-7474.5
UBB	-5890.5
PPP2CB	-5145.5
BRAF	-4674.5
CBL	-4657.5
GRB2	-2220.5
PTPN11	-1453.5
SRC	1212.5

---

Aberrant regulation of mitotic exit in cancer due to RB1 defects

Aberrant regulation of mitotic exit in cancer due to RB1 defects

	23
set	Aberrant regulation of mitotic exit in cancer due to RB1 defects
setSize	18
pANOVA	0.0124
s.dist	-0.34
p.adjustANOVA	0.0565

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ANAPC7	-10044.5
ANAPC10	-9790.0
CDC23	-9279.5
ANAPC15	-8853.5
ANAPC1	-8623.5
FZR1	-8519.5
RB1	-8397.5
UBE2E1	-8329.5
ANAPC16	-8113.5
SKP2	-7001.0
ANAPC5	-5955.5
ANAPC4	-5676.5
ANAPC2	-4120.0
UBE2D1	-3813.5
ANAPC11	-2966.5
UBE2C	-1905.5
UBE2S	0.5
CDC16	1131.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ANAPC7	-10044.5
ANAPC10	-9790.0
CDC23	-9279.5
ANAPC15	-8853.5
ANAPC1	-8623.5
FZR1	-8519.5
RB1	-8397.5
UBE2E1	-8329.5
ANAPC16	-8113.5
SKP2	-7001.0
ANAPC5	-5955.5
ANAPC4	-5676.5
ANAPC2	-4120.0
UBE2D1	-3813.5
ANAPC11	-2966.5
UBE2C	-1905.5
UBE2S	0.5
CDC16	1131.5

---

ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression

ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression

	278
set	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
setSize	15
pANOVA	0.0228
s.dist	-0.339
p.adjustANOVA	0.0869

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EHMT2	-10089.5
GATAD2B	-9675.5
CHD4	-9435.5
CHD3	-9405.5
ERCC6	-8488.5
MTA3	-8385.5
HDAC2	-8146.5
HDAC1	-8140.5
GATAD2A	-7786.5
CBX3	-7261.5
MBD3	-2721.5
H2AFX	-1621.5
TTF1	-1139.5
RBBP4	-809.0
MTA2	1300.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EHMT2	-10089.5
GATAD2B	-9675.5
CHD4	-9435.5
CHD3	-9405.5
ERCC6	-8488.5
MTA3	-8385.5
HDAC2	-8146.5
HDAC1	-8140.5
GATAD2A	-7786.5
CBX3	-7261.5
MBD3	-2721.5
H2AFX	-1621.5
TTF1	-1139.5
RBBP4	-809.0
MTA2	1300.5

---

Defective homologous recombination repair (HRR) due to BRCA2 loss of function

Defective homologous recombination repair (HRR) due to BRCA2 loss of function

	215
set	Defective homologous recombination repair (HRR) due to BRCA2 loss of function
setSize	37
pANOVA	0.000352
s.dist	-0.339
p.adjustANOVA	0.00492

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATM	-10077.0
RAD9B	-9886.0
TOPBP1	-9636.5
BRCA1	-9585.0
RAD17	-9213.0
RFC5	-9018.5
RAD51AP1	-8997.0
RMI1	-8664.0
RBBP8	-8435.5
TOP3A	-8205.0
ATRIP	-7955.5
ATR	-7840.5
RAD9A	-7827.5
RFC3	-7644.5
BRIP1	-7547.5
RPA1	-7258.0
RAD51	-6975.5
RAD1	-6858.0
RAD51B	-6749.5
RFC4	-6563.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATM	-10077.0
RAD9B	-9886.0
TOPBP1	-9636.5
BRCA1	-9585.0
RAD17	-9213.0
RFC5	-9018.5
RAD51AP1	-8997.0
RMI1	-8664.0
RBBP8	-8435.5
TOP3A	-8205.0
ATRIP	-7955.5
ATR	-7840.5
RAD9A	-7827.5
RFC3	-7644.5
BRIP1	-7547.5
RPA1	-7258.0
RAD51	-6975.5
RAD1	-6858.0
RAD51B	-6749.5
RFC4	-6563.5
RPA3	-6476.5
BRCA2	-5847.5
DNA2	-5765.5
PALB2	-5578.0
KAT5	-5567.5
NBN	-5346.5
EXO1	-4768.5
RMI2	-4253.5
RFC2	-4130.5
RAD50	-3747.5
RHNO1	-3722.5
XRCC2	-2900.5
HUS1	-2189.5
BLM	-2156.5
BARD1	-670.5
RAD51D	0.5
WRN	1750.0

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report