date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##           metric
## PSMB8  -15.09965
## TAPBP  -14.48290
## CSNK2B -18.35266
## TAP1   -13.58930
## TRIM27 -17.73811
## BAT4   -18.19374
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2546
num_genes_in_profile 12012
duplicated_genes_present 0
num_profile_genes_in_sets 5835
num_profile_genes_not_in_sets 6177

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2546
num_genesets_excluded 1344
num_genesets_included 1202

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Signaling by FGFR2 IIIa TM 15 9.84e-05 -0.581 0.00169
TNFs bind their physiological receptors 10 9.35e-03 0.475 0.03660
Inhibition of DNA recombination at telomere 18 6.78e-04 -0.463 0.00559
FGFR2 mutant receptor activation 17 1.17e-03 -0.455 0.00775
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 8.90e-03 -0.436 0.03530
TNFR1-induced proapoptotic signaling 12 9.03e-03 -0.435 0.03560
mRNA Capping 26 2.06e-04 -0.421 0.00239
Signaling by FGFR2 in disease 24 3.66e-04 -0.420 0.00352
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 2.14e-02 0.420 0.07260
Purine salvage 11 1.76e-02 -0.413 0.06270
Abortive elongation of HIV-1 transcript in the absence of Tat 22 9.32e-04 -0.408 0.00691
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 2.74e-02 -0.403 0.08630
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 5.49e-03 -0.401 0.02360
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 5.49e-03 -0.401 0.02360
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 2.88e-02 0.399 0.08960
Assembly of the ORC complex at the origin of replication 10 2.93e-02 0.398 0.09080
Endosomal/Vacuolar pathway 10 2.97e-02 -0.397 0.09140
RNA Pol II CTD phosphorylation and interaction with CE 24 8.47e-04 -0.394 0.00656
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 24 8.47e-04 -0.394 0.00656
FGFR2 alternative splicing 22 1.57e-03 -0.389 0.00921
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 3.93e-02 -0.376 0.11300
alpha-linolenic acid (ALA) metabolism 10 3.93e-02 -0.376 0.11300
Processing of Intronless Pre-mRNAs 15 1.25e-02 -0.373 0.04680
SUMOylation of immune response proteins 10 4.43e-02 -0.367 0.12600
Other semaphorin interactions 10 4.54e-02 0.365 0.12800
Signaling by ERBB2 ECD mutants 10 4.65e-02 -0.364 0.13100
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 26 1.58e-03 -0.358 0.00921
Disorders of Developmental Biology 10 5.00e-02 -0.358 0.13500
Disorders of Nervous System Development 10 5.00e-02 -0.358 0.13500
Loss of function of MECP2 in Rett syndrome 10 5.00e-02 -0.358 0.13500
Pervasive developmental disorders 10 5.00e-02 -0.358 0.13500
Degradation of cysteine and homocysteine 10 5.03e-02 -0.357 0.13600
HIV elongation arrest and recovery 27 1.33e-03 -0.357 0.00838
Pausing and recovery of HIV elongation 27 1.33e-03 -0.357 0.00838
HIV Transcription Initiation 39 1.26e-04 -0.355 0.00175
RNA Polymerase II HIV Promoter Escape 39 1.26e-04 -0.355 0.00175
RNA Polymerase II Promoter Escape 39 1.26e-04 -0.355 0.00175
RNA Polymerase II Transcription Initiation 39 1.26e-04 -0.355 0.00175
RNA Polymerase II Transcription Initiation And Promoter Clearance 39 1.26e-04 -0.355 0.00175
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 39 1.26e-04 -0.355 0.00175
Processing of Capped Intronless Pre-mRNA 23 3.31e-03 -0.354 0.01650
Purine ribonucleoside monophosphate biosynthesis 10 5.39e-02 -0.352 0.14200
PIWI-interacting RNA (piRNA) biogenesis 16 1.50e-02 -0.351 0.05440
Cross-presentation of soluble exogenous antigens (endosomes) 38 1.80e-04 -0.351 0.00223
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 44 5.62e-05 -0.351 0.00111
p53-Independent DNA Damage Response 44 5.62e-05 -0.351 0.00111
p53-Independent G1/S DNA damage checkpoint 44 5.62e-05 -0.351 0.00111
Viral Messenger RNA Synthesis 41 1.08e-04 -0.350 0.00175
Striated Muscle Contraction 10 5.69e-02 -0.348 0.14700
Formation of the Early Elongation Complex 30 1.26e-03 -0.340 0.00815


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Signaling by FGFR2 IIIa TM 15 9.84e-05 -0.581000 1.69e-03
TNFs bind their physiological receptors 10 9.35e-03 0.475000 3.66e-02
Inhibition of DNA recombination at telomere 18 6.78e-04 -0.463000 5.59e-03
FGFR2 mutant receptor activation 17 1.17e-03 -0.455000 7.75e-03
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 8.90e-03 -0.436000 3.53e-02
TNFR1-induced proapoptotic signaling 12 9.03e-03 -0.435000 3.56e-02
mRNA Capping 26 2.06e-04 -0.421000 2.39e-03
Signaling by FGFR2 in disease 24 3.66e-04 -0.420000 3.52e-03
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 2.14e-02 0.420000 7.26e-02
Purine salvage 11 1.76e-02 -0.413000 6.27e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 22 9.32e-04 -0.408000 6.91e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 2.74e-02 -0.403000 8.63e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 5.49e-03 -0.401000 2.36e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 5.49e-03 -0.401000 2.36e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 2.88e-02 0.399000 8.96e-02
Assembly of the ORC complex at the origin of replication 10 2.93e-02 0.398000 9.08e-02
Endosomal/Vacuolar pathway 10 2.97e-02 -0.397000 9.14e-02
RNA Pol II CTD phosphorylation and interaction with CE 24 8.47e-04 -0.394000 6.56e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 24 8.47e-04 -0.394000 6.56e-03
FGFR2 alternative splicing 22 1.57e-03 -0.389000 9.21e-03
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 3.93e-02 -0.376000 1.13e-01
alpha-linolenic acid (ALA) metabolism 10 3.93e-02 -0.376000 1.13e-01
Processing of Intronless Pre-mRNAs 15 1.25e-02 -0.373000 4.68e-02
SUMOylation of immune response proteins 10 4.43e-02 -0.367000 1.26e-01
Other semaphorin interactions 10 4.54e-02 0.365000 1.28e-01
Signaling by ERBB2 ECD mutants 10 4.65e-02 -0.364000 1.31e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 26 1.58e-03 -0.358000 9.21e-03
Disorders of Developmental Biology 10 5.00e-02 -0.358000 1.35e-01
Disorders of Nervous System Development 10 5.00e-02 -0.358000 1.35e-01
Loss of function of MECP2 in Rett syndrome 10 5.00e-02 -0.358000 1.35e-01
Pervasive developmental disorders 10 5.00e-02 -0.358000 1.35e-01
Degradation of cysteine and homocysteine 10 5.03e-02 -0.357000 1.36e-01
HIV elongation arrest and recovery 27 1.33e-03 -0.357000 8.38e-03
Pausing and recovery of HIV elongation 27 1.33e-03 -0.357000 8.38e-03
HIV Transcription Initiation 39 1.26e-04 -0.355000 1.75e-03
RNA Polymerase II HIV Promoter Escape 39 1.26e-04 -0.355000 1.75e-03
RNA Polymerase II Promoter Escape 39 1.26e-04 -0.355000 1.75e-03
RNA Polymerase II Transcription Initiation 39 1.26e-04 -0.355000 1.75e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance 39 1.26e-04 -0.355000 1.75e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 39 1.26e-04 -0.355000 1.75e-03
Processing of Capped Intronless Pre-mRNA 23 3.31e-03 -0.354000 1.65e-02
Purine ribonucleoside monophosphate biosynthesis 10 5.39e-02 -0.352000 1.42e-01
PIWI-interacting RNA (piRNA) biogenesis 16 1.50e-02 -0.351000 5.44e-02
Cross-presentation of soluble exogenous antigens (endosomes) 38 1.80e-04 -0.351000 2.23e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 44 5.62e-05 -0.351000 1.11e-03
p53-Independent DNA Damage Response 44 5.62e-05 -0.351000 1.11e-03
p53-Independent G1/S DNA damage checkpoint 44 5.62e-05 -0.351000 1.11e-03
Viral Messenger RNA Synthesis 41 1.08e-04 -0.350000 1.75e-03
Striated Muscle Contraction 10 5.69e-02 -0.348000 1.47e-01
Formation of the Early Elongation Complex 30 1.26e-03 -0.340000 8.15e-03
Formation of the HIV-1 Early Elongation Complex 30 1.26e-03 -0.340000 8.15e-03
Gluconeogenesis 24 3.97e-03 -0.340000 1.83e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 3.53e-02 -0.337000 1.04e-01
Defects in vitamin and cofactor metabolism 16 1.97e-02 -0.337000 6.78e-02
Binding and Uptake of Ligands by Scavenger Receptors 10 6.54e-02 -0.336000 1.62e-01
Constitutive Signaling by EGFRvIII 10 6.58e-02 -0.336000 1.62e-01
Signaling by EGFRvIII in Cancer 10 6.58e-02 -0.336000 1.62e-01
Degradation of GLI2 by the proteasome 50 4.16e-05 -0.335000 9.13e-04
GLI3 is processed to GLI3R by the proteasome 50 4.16e-05 -0.335000 9.13e-04
Pausing and recovery of Tat-mediated HIV elongation 26 3.12e-03 -0.335000 1.56e-02
Tat-mediated HIV elongation arrest and recovery 26 3.12e-03 -0.335000 1.56e-02
Formation of HIV elongation complex in the absence of HIV Tat 37 4.38e-04 -0.334000 4.01e-03
Association of TriC/CCT with target proteins during biosynthesis 29 1.87e-03 -0.334000 1.06e-02
Ubiquitin-dependent degradation of Cyclin D 44 1.30e-04 -0.334000 1.75e-03
TRAF6 mediated IRF7 activation 16 2.10e-02 -0.333000 7.13e-02
Nucleotide salvage 18 1.45e-02 -0.333000 5.31e-02
Sulfur amino acid metabolism 17 1.76e-02 -0.333000 6.27e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 41 2.37e-04 -0.332000 2.64e-03
Metabolism of folate and pterines 11 5.68e-02 -0.332000 1.47e-01
Transport of Mature mRNA Derived from an Intronless Transcript 40 2.85e-04 -0.332000 3.03e-03
TRAF6 mediated NF-kB activation 19 1.28e-02 -0.330000 4.76e-02
Signaling by PDGFR in disease 15 2.79e-02 -0.328000 8.74e-02
Synthesis of glycosylphosphatidylinositol (GPI) 14 3.42e-02 -0.327000 1.01e-01
Regulation of PTEN stability and activity 56 2.73e-05 -0.324000 7.14e-04
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 46 1.63e-04 -0.321000 2.08e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 1.71e-04 -0.320000 2.17e-03
Rev-mediated nuclear export of HIV RNA 33 1.51e-03 -0.319000 8.96e-03
Interactions of Rev with host cellular proteins 34 1.29e-03 -0.319000 8.28e-03
Processive synthesis on the lagging strand 13 4.65e-02 -0.319000 1.31e-01
Keratan sulfate/keratin metabolism 18 1.93e-02 -0.318000 6.71e-02
Generation of second messenger molecules 15 3.29e-02 0.318000 9.74e-02
SCF(Skp2)-mediated degradation of p27/p21 52 7.35e-05 -0.318000 1.40e-03
Formation of HIV-1 elongation complex containing HIV-1 Tat 36 9.77e-04 -0.318000 7.03e-03
HIV Transcription Elongation 36 9.77e-04 -0.318000 7.03e-03
Tat-mediated elongation of the HIV-1 transcript 36 9.77e-04 -0.318000 7.03e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 19 1.68e-02 -0.317000 6.03e-02
Role of phospholipids in phagocytosis 16 2.83e-02 -0.317000 8.84e-02
Degradation of GLI1 by the proteasome 51 9.34e-05 -0.316000 1.63e-03
Lagging Strand Synthesis 17 2.40e-02 -0.316000 7.87e-02
Autodegradation of the E3 ubiquitin ligase COP1 44 2.91e-04 -0.316000 3.04e-03
Negative regulation of NOTCH4 signaling 48 1.56e-04 -0.316000 2.02e-03
ERKs are inactivated 11 7.02e-02 -0.315000 1.67e-01
Transcription of the HIV genome 57 4.18e-05 -0.314000 9.13e-04
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 5.00e-02 -0.314000 1.35e-01
B-WICH complex positively regulates rRNA expression 27 4.84e-03 -0.313000 2.16e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 6.11e-02 -0.312000 1.53e-01
Elevation of cytosolic Ca2+ levels 10 8.77e-02 -0.312000 1.97e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 26 5.95e-03 -0.312000 2.51e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 27 5.21e-03 -0.311000 2.29e-02
Degradation of AXIN 47 2.40e-04 -0.310000 2.64e-03
Vif-mediated degradation of APOBEC3G 43 4.52e-04 -0.309000 4.05e-03
Diseases associated with N-glycosylation of proteins 18 2.31e-02 -0.309000 7.70e-02
Glycogen synthesis 11 7.68e-02 -0.308000 1.79e-01
Vpr-mediated nuclear import of PICs 32 2.63e-03 -0.307000 1.39e-02
MicroRNA (miRNA) biogenesis 21 1.52e-02 -0.306000 5.48e-02
Formation of tubulin folding intermediates by CCT/TriC 14 4.74e-02 -0.306000 1.31e-01
Interleukin-7 signaling 14 4.76e-02 -0.306000 1.31e-01
Interleukin-35 Signalling 11 7.92e-02 -0.306000 1.82e-01
Loss of Nlp from mitotic centrosomes 56 8.80e-05 -0.303000 1.56e-03
Loss of proteins required for interphase microtubule organization from the centrosome 56 8.80e-05 -0.303000 1.56e-03
Prefoldin mediated transfer of substrate to CCT/TriC 17 3.11e-02 -0.302000 9.36e-02
NRIF signals cell death from the nucleus 14 5.06e-02 -0.302000 1.36e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 7.24e-04 -0.302000 5.80e-03
Interactions of Vpr with host cellular proteins 33 2.80e-03 -0.301000 1.45e-02
CLEC7A (Dectin-1) induces NFAT activation 11 8.42e-02 -0.301000 1.91e-01
RNA Polymerase II Pre-transcription Events 68 1.88e-05 -0.300000 5.45e-04
Formation of RNA Pol II elongation complex 50 2.41e-04 -0.300000 2.64e-03
RNA Polymerase II Transcription Elongation 50 2.41e-04 -0.300000 2.64e-03
Voltage gated Potassium channels 13 6.09e-02 0.300000 1.53e-01
Removal of the Flap Intermediate 12 7.27e-02 -0.299000 1.71e-01
Peptide ligand-binding receptors 20 2.08e-02 0.299000 7.09e-02
Dual incision in TC-NER 56 1.15e-04 -0.298000 1.75e-03
Vpu mediated degradation of CD4 44 6.53e-04 -0.297000 5.44e-03
Gap-filling DNA repair synthesis and ligation in TC-NER 55 1.45e-04 -0.296000 1.92e-03
SCF-beta-TrCP mediated degradation of Emi1 47 4.49e-04 -0.296000 4.05e-03
Telomere C-strand (Lagging Strand) Synthesis 29 5.93e-03 -0.295000 2.51e-02
Export of Viral Ribonucleoproteins from Nucleus 31 4.53e-03 -0.295000 2.03e-02
Hedgehog ligand biogenesis 52 2.40e-04 -0.295000 2.64e-03
RNA Polymerase III Transcription Termination 21 1.96e-02 -0.294000 6.78e-02
Regulation of PTEN mRNA translation 11 9.15e-02 0.294000 2.02e-01
Regulation of Apoptosis 45 6.56e-04 -0.294000 5.44e-03
Anchoring of the basal body to the plasma membrane 80 6.34e-06 -0.292000 2.18e-04
G1/S DNA Damage Checkpoints 58 1.26e-04 -0.291000 1.75e-03
TRAF3-dependent IRF activation pathway 14 6.02e-02 -0.290000 1.53e-01
ER-Phagosome pathway 69 3.21e-05 -0.290000 7.57e-04
RAF-independent MAPK1/3 activation 20 2.55e-02 -0.289000 8.21e-02
Regulation of ornithine decarboxylase (ODC) 43 1.08e-03 -0.288000 7.59e-03
Regulation of RUNX2 expression and activity 57 1.77e-04 -0.287000 2.22e-03
Transport of the SLBP Dependant Mature mRNA 34 3.76e-03 -0.287000 1.80e-02
Cyclin E associated events during G1/S transition 72 2.72e-05 -0.286000 7.14e-04
Nuclear import of Rev protein 31 5.86e-03 -0.286000 2.50e-02
Transport of the SLBP independent Mature mRNA 33 4.53e-03 -0.286000 2.03e-02
GAB1 signalosome 10 1.18e-01 -0.286000 2.41e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 8.12e-04 -0.285000 6.42e-03
Signaling by NTRK2 (TRKB) 15 5.60e-02 -0.285000 1.47e-01
Regulation of RAS by GAPs 56 2.28e-04 -0.285000 2.61e-03
Notch-HLH transcription pathway 21 2.41e-02 -0.284000 7.89e-02
Glucose metabolism 72 3.15e-05 -0.284000 7.57e-04
Polymerase switching on the C-strand of the telomere 22 2.16e-02 -0.283000 7.30e-02
Ovarian tumor domain proteases 29 8.54e-03 -0.282000 3.42e-02
RORA activates gene expression 11 1.07e-01 -0.281000 2.25e-01
Telomere C-strand synthesis initiation 10 1.25e-01 -0.280000 2.50e-01
Cyclin A:Cdk2-associated events at S phase entry 74 3.11e-05 -0.280000 7.57e-04
VEGFR2 mediated cell proliferation 16 5.28e-02 -0.280000 1.40e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 16 5.36e-02 -0.279000 1.41e-01
Leading Strand Synthesis 12 9.61e-02 -0.277000 2.09e-01
Polymerase switching 12 9.61e-02 -0.277000 2.09e-01
p53-Dependent G1 DNA Damage Response 56 3.43e-04 -0.277000 3.37e-03
p53-Dependent G1/S DNA damage checkpoint 56 3.43e-04 -0.277000 3.37e-03
HCMV Early Events 50 7.31e-04 -0.276000 5.82e-03
TP53 Regulates Transcription of DNA Repair Genes 52 5.83e-04 -0.276000 5.08e-03
Heme signaling 26 1.51e-02 -0.275000 5.48e-02
NEP/NS2 Interacts with the Cellular Export Machinery 30 9.16e-03 -0.275000 3.60e-02
Synaptic adhesion-like molecules 10 1.32e-01 0.275000 2.63e-01
Transcriptional regulation by small RNAs 45 1.47e-03 -0.274000 8.83e-03
Platelet calcium homeostasis 17 5.06e-02 -0.274000 1.36e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 3.56e-02 -0.271000 1.04e-01
Neurodegenerative Diseases 20 3.56e-02 -0.271000 1.04e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 6.91e-02 -0.271000 1.67e-01
Antigen processing-Cross presentation 76 4.53e-05 -0.271000 9.72e-04
Postmitotic nuclear pore complex (NPC) reformation 26 1.71e-02 -0.270000 6.12e-02
Diseases of programmed cell death 37 4.49e-03 -0.270000 2.03e-02
AURKA Activation by TPX2 59 3.52e-04 -0.269000 3.41e-03
G1/S-Specific Transcription 27 1.55e-02 -0.269000 5.59e-02
HDR through Single Strand Annealing (SSA) 35 5.92e-03 -0.269000 2.51e-02
Hh mutants abrogate ligand secretion 49 1.14e-03 -0.269000 7.72e-03
Regulation of RUNX3 expression and activity 49 1.15e-03 -0.269000 7.73e-03
Early Phase of HIV Life Cycle 13 9.42e-02 -0.268000 2.06e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 69 1.23e-04 -0.267000 1.75e-03
SUMOylation of SUMOylation proteins 32 8.93e-03 -0.267000 3.53e-02
Dectin-1 mediated noncanonical NF-kB signaling 52 8.69e-04 -0.267000 6.57e-03
The role of GTSE1 in G2/M progression after G2 checkpoint 52 8.74e-04 -0.267000 6.57e-03
DNA strand elongation 28 1.47e-02 -0.266000 5.38e-02
Processive synthesis on the C-strand of the telomere 17 5.75e-02 -0.266000 1.48e-01
Degradation of beta-catenin by the destruction complex 68 1.49e-04 -0.266000 1.95e-03
Degradation of DVL 48 1.46e-03 -0.266000 8.83e-03
Triglyceride catabolism 11 1.28e-01 -0.265000 2.55e-01
Stabilization of p53 49 1.35e-03 -0.265000 8.45e-03
Signaling by FGFR in disease 39 4.23e-03 -0.265000 1.92e-02
Asymmetric localization of PCP proteins 51 1.10e-03 -0.264000 7.59e-03
mRNA Splicing - Minor Pathway 49 1.38e-03 -0.264000 8.55e-03
NIK–>noncanonical NF-kB signaling 51 1.11e-03 -0.264000 7.59e-03
Base-Excision Repair, AP Site Formation 15 7.70e-02 -0.264000 1.79e-01
Hh mutants are degraded by ERAD 47 1.77e-03 -0.264000 1.02e-02
Mismatch Repair 13 1.00e-01 -0.263000 2.14e-01
Interleukin-6 signaling 10 1.51e-01 -0.263000 2.84e-01
DNA Damage/Telomere Stress Induced Senescence 24 2.60e-02 -0.263000 8.32e-02
Elastic fibre formation 17 6.10e-02 0.262000 1.53e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 8.92e-02 -0.262000 1.99e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 8.92e-02 -0.262000 1.99e-01
Signaling by NOTCH4 68 1.88e-04 -0.262000 2.27e-03
Host Interactions of HIV factors 106 3.46e-06 -0.261000 1.30e-04
Diseases associated with glycosylation precursor biosynthesis 15 8.03e-02 -0.261000 1.84e-01
Synthesis of IP3 and IP4 in the cytosol 16 7.10e-02 -0.261000 1.68e-01
Rap1 signalling 11 1.36e-01 -0.260000 2.66e-01
Defective Intrinsic Pathway for Apoptosis 23 3.13e-02 -0.259000 9.39e-02
Transport of Ribonucleoproteins into the Host Nucleus 30 1.40e-02 -0.259000 5.17e-02
RIPK1-mediated regulated necrosis 25 2.50e-02 -0.259000 8.09e-02
Regulation of necroptotic cell death 25 2.50e-02 -0.259000 8.09e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 10 1.56e-01 0.259000 2.89e-01
Ub-specific processing proteases 134 2.56e-07 -0.258000 1.40e-05
TP53 Regulates Transcription of Cell Cycle Genes 43 3.41e-03 -0.258000 1.68e-02
Glyoxylate metabolism and glycine degradation 19 5.14e-02 -0.258000 1.36e-01
Nuclear events mediated by NFE2L2 67 2.65e-04 -0.258000 2.84e-03
Beta-catenin phosphorylation cascade 15 8.46e-02 -0.257000 1.91e-01
Resolution of Sister Chromatid Cohesion 92 2.12e-05 -0.257000 5.92e-04
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 1.40e-01 -0.257000 2.70e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 10 1.61e-01 -0.256000 2.95e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 63 4.46e-04 -0.256000 4.05e-03
Collagen degradation 14 9.91e-02 0.255000 2.13e-01
Formation of TC-NER Pre-Incision Complex 46 2.95e-03 -0.254000 1.50e-02
RNA Polymerase III Chain Elongation 17 7.07e-02 -0.253000 1.68e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 28 2.05e-02 -0.253000 7.00e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 28 2.05e-02 -0.253000 7.00e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 8.98e-02 -0.253000 1.99e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 62 5.92e-04 -0.252000 5.12e-03
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 18 6.39e-02 -0.252000 1.59e-01
Separation of Sister Chromatids 147 1.47e-07 -0.252000 9.28e-06
Regulation of expression of SLITs and ROBOs 124 1.37e-06 -0.251000 5.75e-05
Influenza Infection 130 7.70e-07 -0.251000 3.56e-05
tRNA Aminoacylation 23 3.75e-02 -0.251000 1.09e-01
Telomere Maintenance 57 1.10e-03 -0.250000 7.59e-03
RNA Polymerase I Transcription Termination 25 3.09e-02 -0.249000 9.33e-02
CLEC7A (Dectin-1) signaling 84 8.06e-05 -0.249000 1.51e-03
APC/C:Cdc20 mediated degradation of mitotic proteins 65 5.34e-04 -0.249000 4.72e-03
PCNA-Dependent Long Patch Base Excision Repair 18 6.85e-02 -0.248000 1.66e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 45 4.14e-03 -0.247000 1.89e-02
Vitamin B5 (pantothenate) metabolism 11 1.56e-01 -0.247000 2.89e-01
Sema4D induced cell migration and growth-cone collapse 12 1.39e-01 0.247000 2.70e-01
RNA Polymerase I Promoter Escape 27 2.66e-02 -0.247000 8.43e-02
HIV Life Cycle 129 1.39e-06 -0.247000 5.75e-05
Mitochondrial tRNA aminoacylation 18 7.03e-02 -0.246000 1.67e-01
SARS-CoV-2 modulates autophagy 11 1.57e-01 -0.246000 2.89e-01
APC truncation mutants have impaired AXIN binding 12 1.40e-01 -0.246000 2.70e-01
AXIN missense mutants destabilize the destruction complex 12 1.40e-01 -0.246000 2.70e-01
Signaling by AMER1 mutants 12 1.40e-01 -0.246000 2.70e-01
Signaling by APC mutants 12 1.40e-01 -0.246000 2.70e-01
Signaling by AXIN mutants 12 1.40e-01 -0.246000 2.70e-01
Truncations of AMER1 destabilize the destruction complex 12 1.40e-01 -0.246000 2.70e-01
MAPK6/MAPK4 signaling 69 4.11e-04 -0.246000 3.83e-03
Base Excision Repair 38 8.73e-03 -0.246000 3.48e-02
G-protein activation 13 1.25e-01 0.246000 2.50e-01
Signaling by ALK 18 7.15e-02 -0.245000 1.69e-01
Late Phase of HIV Life Cycle 117 5.20e-06 -0.244000 1.84e-04
Influenza Viral RNA Transcription and Replication 113 7.73e-06 -0.244000 2.58e-04
Metabolism of polyamines 48 3.53e-03 -0.244000 1.72e-02
UCH proteinases 74 2.97e-04 -0.243000 3.08e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 83 1.29e-04 -0.243000 1.75e-03
Amplification of signal from the kinetochores 83 1.29e-04 -0.243000 1.75e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 66 6.36e-04 -0.243000 5.38e-03
Chromosome Maintenance 78 2.07e-04 -0.243000 2.39e-03
Resolution of Abasic Sites (AP sites) 31 1.92e-02 -0.243000 6.69e-02
Recruitment of NuMA to mitotic centrosomes 65 7.08e-04 -0.243000 5.75e-03
Glycolysis 57 1.52e-03 -0.243000 9.01e-03
Signaling by FLT3 ITD and TKD mutants 12 1.45e-01 -0.243000 2.77e-01
G2/M DNA damage checkpoint 54 2.04e-03 -0.243000 1.13e-02
Interleukin-1 signaling 79 1.94e-04 -0.243000 2.31e-03
APC/C:Cdc20 mediated degradation of Securin 58 1.43e-03 -0.242000 8.77e-03
FCERI mediated NF-kB activation 64 8.58e-04 -0.241000 6.56e-03
Defective pyroptosis 10 1.89e-01 -0.240000 3.35e-01
Diseases of DNA repair 45 5.39e-03 -0.240000 2.33e-02
Activation of NF-kappaB in B cells 57 1.75e-03 -0.240000 1.02e-02
Nucleotide Excision Repair 99 4.05e-05 -0.239000 9.13e-04
SUMOylation of intracellular receptors 19 7.21e-02 -0.238000 1.70e-01
NS1 Mediated Effects on Host Pathways 38 1.12e-02 -0.238000 4.30e-02
RUNX3 regulates NOTCH signaling 11 1.73e-01 -0.237000 3.11e-01
HIV Infection 190 1.91e-08 -0.237000 1.77e-06
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 16 1.01e-01 -0.237000 2.16e-01
G1/S Transition 115 1.20e-05 -0.237000 3.81e-04
G0 and Early G1 24 4.50e-02 -0.236000 1.27e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 53 3.02e-03 -0.236000 1.53e-02
Signaling by NOTCH2 18 8.36e-02 -0.236000 1.90e-01
Retrograde transport at the Trans-Golgi-Network 45 6.45e-03 -0.235000 2.67e-02
TBC/RABGAPs 40 1.05e-02 -0.234000 4.06e-02
Potassium Channels 30 2.68e-02 0.234000 8.47e-02
Cellular response to hypoxia 60 1.76e-03 -0.234000 1.02e-02
Defective CFTR causes cystic fibrosis 52 3.60e-03 -0.233000 1.74e-02
Regulation of TP53 Activity through Phosphorylation 79 3.45e-04 -0.233000 3.37e-03
Autodegradation of Cdh1 by Cdh1:APC/C 56 2.57e-03 -0.233000 1.37e-02
Caspase activation via Death Receptors in the presence of ligand 10 2.03e-01 -0.232000 3.55e-01
SUMOylation of ubiquitinylation proteins 37 1.48e-02 -0.232000 5.39e-02
RUNX3 regulates p14-ARF 10 2.05e-01 -0.231000 3.57e-01
Mitotic Prometaphase 158 5.78e-07 -0.231000 2.78e-05
Estrogen-dependent gene expression 70 8.51e-04 -0.231000 6.56e-03
Transport of Mature Transcript to Cytoplasm 64 1.44e-03 -0.231000 8.77e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 88 1.89e-04 -0.231000 2.27e-03
Nonsense-Mediated Decay (NMD) 88 1.89e-04 -0.231000 2.27e-03
Translesion synthesis by POLI 15 1.22e-01 -0.230000 2.47e-01
Class A/1 (Rhodopsin-like receptors) 49 5.34e-03 0.230000 2.32e-02
Positive epigenetic regulation of rRNA expression 40 1.19e-02 -0.230000 4.51e-02
Deposition of new CENPA-containing nucleosomes at the centromere 23 5.64e-02 -0.230000 1.47e-01
Nucleosome assembly 23 5.64e-02 -0.230000 1.47e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 1.87e-01 -0.230000 3.32e-01
CDK-mediated phosphorylation and removal of Cdc6 62 1.77e-03 -0.230000 1.02e-02
RNA Polymerase I Transcription Initiation 40 1.26e-02 -0.228000 4.73e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 74 7.07e-04 -0.228000 5.75e-03
CTNNB1 S33 mutants aren’t phosphorylated 13 1.55e-01 -0.228000 2.88e-01
CTNNB1 S37 mutants aren’t phosphorylated 13 1.55e-01 -0.228000 2.88e-01
CTNNB1 S45 mutants aren’t phosphorylated 13 1.55e-01 -0.228000 2.88e-01
CTNNB1 T41 mutants aren’t phosphorylated 13 1.55e-01 -0.228000 2.88e-01
Signaling by CTNNB1 phospho-site mutants 13 1.55e-01 -0.228000 2.88e-01
Signaling by GSK3beta mutants 13 1.55e-01 -0.228000 2.88e-01
Deubiquitination 198 3.72e-08 -0.228000 2.80e-06
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 1.74e-01 -0.227000 3.11e-01
Mitotic G1 phase and G1/S transition 129 9.08e-06 -0.227000 2.95e-04
Hedgehog ‘on’ state 63 1.95e-03 -0.226000 1.09e-02
RHO GTPases Activate Formins 102 8.45e-05 -0.226000 1.54e-03
TNFR1-induced NFkappaB signaling pathway 20 8.08e-02 -0.226000 1.85e-01
tRNA processing in the nucleus 55 3.87e-03 -0.225000 1.82e-02
Downstream signaling events of B Cell Receptor (BCR) 70 1.13e-03 -0.225000 7.72e-03
KEAP1-NFE2L2 pathway 86 3.25e-04 -0.224000 3.31e-03
Gene Silencing by RNA 62 2.26e-03 -0.224000 1.24e-02
Polo-like kinase mediated events 15 1.34e-01 -0.224000 2.65e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 57 3.52e-03 -0.224000 1.72e-02
EML4 and NUDC in mitotic spindle formation 87 3.29e-04 -0.223000 3.32e-03
Signaling by ROBO receptors 154 1.89e-06 -0.223000 7.58e-05
Signaling by EGFR in Cancer 16 1.25e-01 -0.222000 2.50e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 23 6.60e-02 -0.221000 1.62e-01
Centrosome maturation 66 1.92e-03 -0.221000 1.08e-02
Recruitment of mitotic centrosome proteins and complexes 66 1.92e-03 -0.221000 1.08e-02
Orc1 removal from chromatin 62 2.66e-03 -0.221000 1.40e-02
Regulation of APC/C activators between G1/S and early anaphase 70 1.44e-03 -0.220000 8.77e-03
Downstream signal transduction 20 8.84e-02 -0.220000 1.98e-01
Purine catabolism 10 2.28e-01 -0.220000 3.86e-01
Diseases associated with O-glycosylation of proteins 21 8.09e-02 0.220000 1.85e-01
Dual Incision in GG-NER 35 2.46e-02 -0.220000 8.00e-02
Transcription of E2F targets under negative control by DREAM complex 18 1.07e-01 -0.219000 2.26e-01
Pyruvate metabolism 20 8.99e-02 -0.219000 1.99e-01
Hedgehog ‘off’ state 75 1.07e-03 -0.219000 7.59e-03
RNA Polymerase III Abortive And Retractive Initiation 39 1.82e-02 -0.219000 6.41e-02
RNA Polymerase III Transcription 39 1.82e-02 -0.219000 6.41e-02
Impaired BRCA2 binding to RAD51 32 3.28e-02 -0.218000 9.74e-02
Negative regulators of DDX58/IFIH1 signaling 34 2.78e-02 -0.218000 8.73e-02
ABC transporter disorders 59 3.82e-03 -0.218000 1.81e-02
Meiotic recombination 19 1.00e-01 -0.218000 2.14e-01
Regulation of PLK1 Activity at G2/M Transition 74 1.22e-03 -0.218000 7.94e-03
CD28 dependent PI3K/Akt signaling 18 1.10e-01 -0.218000 2.29e-01
ERK/MAPK targets 16 1.32e-01 -0.217000 2.63e-01
Condensation of Prometaphase Chromosomes 10 2.36e-01 -0.217000 3.95e-01
G2/M Checkpoints 119 4.63e-05 -0.217000 9.77e-04
Glycogen metabolism 17 1.22e-01 -0.216000 2.47e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 48 9.69e-03 -0.216000 3.78e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 84 6.46e-04 -0.216000 5.43e-03
SRP-dependent cotranslational protein targeting to membrane 88 4.84e-04 -0.215000 4.31e-03
Selenoamino acid metabolism 78 1.05e-03 -0.215000 7.46e-03
Mitotic Metaphase and Anaphase 196 2.44e-07 -0.214000 1.40e-05
p75NTR signals via NF-kB 11 2.18e-01 -0.214000 3.73e-01
APC/C-mediated degradation of cell cycle proteins 77 1.17e-03 -0.214000 7.75e-03
Regulation of mitotic cell cycle 77 1.17e-03 -0.214000 7.75e-03
Cleavage of the damaged pyrimidine 14 1.65e-01 -0.214000 3.00e-01
Depyrimidination 14 1.65e-01 -0.214000 3.00e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 14 1.65e-01 -0.214000 3.00e-01
Sema4D in semaphorin signaling 15 1.51e-01 0.214000 2.85e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 41 1.78e-02 -0.214000 6.33e-02
S Phase 141 1.25e-05 -0.214000 3.85e-04
Diseases associated with glycosaminoglycan metabolism 16 1.40e-01 -0.213000 2.70e-01
Mitotic Anaphase 195 3.32e-07 -0.213000 1.74e-05
Long-term potentiation 11 2.22e-01 0.212000 3.78e-01
LDL clearance 12 2.04e-01 -0.212000 3.56e-01
Cap-dependent Translation Initiation 95 3.80e-04 -0.211000 3.59e-03
Eukaryotic Translation Initiation 95 3.80e-04 -0.211000 3.59e-03
Processing of DNA double-strand break ends 55 6.80e-03 -0.211000 2.79e-02
Homology Directed Repair 90 5.63e-04 -0.211000 4.94e-03
Ion homeostasis 26 6.38e-02 -0.210000 1.59e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 64 3.79e-03 -0.209000 1.80e-02
Eukaryotic Translation Termination 72 2.15e-03 -0.209000 1.18e-02
Citric acid cycle (TCA cycle) 19 1.16e-01 -0.208000 2.39e-01
Nuclear Pore Complex (NPC) Disassembly 34 3.57e-02 -0.208000 1.04e-01
Eukaryotic Translation Elongation 72 2.29e-03 -0.208000 1.25e-02
Signaling by NTRK3 (TRKC) 11 2.32e-01 -0.208000 3.91e-01
InlB-mediated entry of Listeria monocytogenes into host cell 11 2.32e-01 -0.208000 3.91e-01
Signaling by Retinoic Acid 17 1.38e-01 -0.208000 2.70e-01
HCMV Infection 71 2.59e-03 -0.207000 1.38e-02
Downstream TCR signaling 71 2.63e-03 -0.207000 1.39e-02
Selenocysteine synthesis 70 2.85e-03 -0.206000 1.47e-02
Regulation of pyruvate dehydrogenase (PDH) complex 11 2.36e-01 -0.206000 3.95e-01
Cell Cycle Checkpoints 228 9.43e-08 -0.206000 6.67e-06
Mitotic Spindle Checkpoint 98 4.37e-04 -0.206000 4.01e-03
Cyclin A/B1/B2 associated events during G2/M transition 22 9.65e-02 -0.205000 2.09e-01
Activation of HOX genes during differentiation 41 2.35e-02 -0.205000 7.78e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 41 2.35e-02 -0.205000 7.78e-02
COPI-mediated anterograde transport 71 2.95e-03 -0.204000 1.50e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 77 2.01e-03 -0.204000 1.12e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 1.72e-01 -0.204000 3.10e-01
Signaling by FGFR2 48 1.47e-02 -0.204000 5.38e-02
RHO GTPases activate CIT 14 1.87e-01 -0.204000 3.33e-01
M Phase 297 2.01e-09 -0.203000 2.01e-07
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 20 1.17e-01 -0.202000 2.40e-01
Glutathione conjugation 21 1.09e-01 -0.202000 2.27e-01
Mitochondrial Fatty Acid Beta-Oxidation 26 7.47e-02 -0.202000 1.75e-01
Triglyceride metabolism 16 1.62e-01 -0.202000 2.96e-01
Removal of the Flap Intermediate from the C-strand 15 1.77e-01 -0.201000 3.17e-01
Activation of gene expression by SREBF (SREBP) 36 3.68e-02 -0.201000 1.07e-01
Thrombin signalling through proteinase activated receptors (PARs) 20 1.19e-01 0.201000 2.43e-01
RNA polymerase II transcribes snRNA genes 71 3.47e-03 -0.201000 1.70e-02
Transcriptional regulation by RUNX3 75 2.69e-03 -0.201000 1.41e-02
Peptide chain elongation 69 4.03e-03 -0.200000 1.85e-02
Mitotic G2-G2/M phases 158 1.51e-05 -0.200000 4.55e-04
Homologous DNA Pairing and Strand Exchange 39 3.10e-02 -0.200000 9.33e-02
Metabolism of carbohydrates 181 3.82e-06 -0.200000 1.39e-04
Organelle biogenesis and maintenance 204 9.52e-07 -0.200000 4.24e-05
DNA Double-Strand Break Repair 117 1.97e-04 -0.200000 2.32e-03
Prostacyclin signalling through prostacyclin receptor 12 2.32e-01 0.199000 3.91e-01
Translesion synthesis by REV1 14 1.98e-01 -0.199000 3.47e-01
Translation 238 1.46e-07 -0.199000 9.28e-06
Class I peroxisomal membrane protein import 19 1.34e-01 -0.199000 2.65e-01
Cilium Assembly 150 2.85e-05 -0.198000 7.28e-04
Apoptosis 133 8.20e-05 -0.198000 1.52e-03
Mitochondrial biogenesis 54 1.18e-02 -0.198000 4.50e-02
Formation of Incision Complex in GG-NER 36 4.01e-02 -0.198000 1.15e-01
Transcriptional regulation by RUNX2 84 1.78e-03 -0.197000 1.02e-02
HDR through Homologous Recombination (HRR) 60 8.45e-03 -0.197000 3.39e-02
G2/M Transition 156 2.35e-05 -0.197000 6.43e-04
Nuclear Receptor transcription pathway 27 7.81e-02 -0.196000 1.81e-01
Arachidonic acid metabolism 21 1.20e-01 0.196000 2.44e-01
Viral mRNA Translation 69 5.02e-03 -0.196000 2.22e-02
Depolymerisation of the Nuclear Lamina 13 2.22e-01 0.195000 3.78e-01
Diseases of mitotic cell cycle 34 4.88e-02 -0.195000 1.34e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 58 1.05e-02 -0.194000 4.06e-02
Signaling by the B Cell Receptor (BCR) 90 1.47e-03 -0.194000 8.83e-03
Formation of a pool of free 40S subunits 78 3.08e-03 -0.194000 1.55e-02
Mitochondrial iron-sulfur cluster biogenesis 12 2.46e-01 -0.194000 4.08e-01
RNA Polymerase I Promoter Clearance 44 2.64e-02 -0.194000 8.40e-02
RNA Polymerase I Transcription 44 2.64e-02 -0.194000 8.40e-02
Nucleotide biosynthesis 12 2.46e-01 -0.193000 4.08e-01
tRNA processing 93 1.30e-03 -0.193000 8.28e-03
ABC-family proteins mediated transport 74 4.10e-03 -0.193000 1.88e-02
Global Genome Nucleotide Excision Repair (GG-NER) 76 3.71e-03 -0.193000 1.78e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation 23 1.10e-01 -0.193000 2.28e-01
Synthesis of DNA 106 6.30e-04 -0.192000 5.37e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 78 3.41e-03 -0.192000 1.68e-02
Intrinsic Pathway for Apoptosis 47 2.29e-02 -0.192000 7.66e-02
Signaling by ERBB2 KD Mutants 12 2.50e-01 -0.192000 4.13e-01
C-type lectin receptors (CLRs) 100 9.71e-04 -0.191000 7.03e-03
SUMOylation of DNA replication proteins 43 3.03e-02 -0.191000 9.28e-02
ABC transporters in lipid homeostasis 10 2.96e-01 0.191000 4.66e-01
Meiosis 42 3.28e-02 -0.190000 9.74e-02
COPI-dependent Golgi-to-ER retrograde traffic 66 7.53e-03 -0.190000 3.06e-02
Regulated Necrosis 43 3.09e-02 -0.190000 9.33e-02
Methylation 10 2.98e-01 -0.190000 4.67e-01
RNA Polymerase III Transcription Initiation 35 5.18e-02 -0.190000 1.37e-01
Cell Cycle, Mitotic 425 2.80e-11 -0.190000 4.80e-09
Golgi-to-ER retrograde transport 95 1.50e-03 -0.189000 8.96e-03
Constitutive Signaling by AKT1 E17K in Cancer 23 1.17e-01 -0.189000 2.40e-01
Unwinding of DNA 11 2.79e-01 -0.189000 4.48e-01
Interleukin-1 family signaling 99 1.21e-03 -0.188000 7.94e-03
Metabolism of non-coding RNA 48 2.42e-02 -0.188000 7.89e-02
snRNP Assembly 48 2.42e-02 -0.188000 7.89e-02
RHO GTPases activate PKNs 26 9.75e-02 -0.188000 2.10e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 88 2.38e-03 -0.188000 1.29e-02
DNA Repair 248 4.03e-07 -0.188000 2.02e-05
Cellular response to chemical stress 145 1.02e-04 -0.187000 1.70e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 88 2.48e-03 -0.187000 1.34e-02
Cytoprotection by HMOX1 44 3.21e-02 -0.187000 9.59e-02
TICAM1-dependent activation of IRF3/IRF7 12 2.64e-01 -0.186000 4.28e-01
Cell Cycle 530 4.69e-13 -0.185000 1.41e-10
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 83 3.67e-03 -0.185000 1.77e-02
Metabolism of water-soluble vitamins and cofactors 82 3.92e-03 -0.184000 1.82e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 33 6.69e-02 -0.184000 1.64e-01
Presynaptic phase of homologous DNA pairing and strand exchange 36 5.61e-02 -0.184000 1.47e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 55 1.87e-02 -0.183000 6.55e-02
RHOD GTPase cycle 36 5.70e-02 0.183000 1.47e-01
Translesion synthesis by POLK 15 2.19e-01 -0.183000 3.74e-01
COPI-independent Golgi-to-ER retrograde traffic 29 8.86e-02 -0.183000 1.98e-01
Cell-cell junction organization 13 2.54e-01 0.183000 4.18e-01
PCP/CE pathway 71 8.05e-03 -0.182000 3.26e-02
Translesion Synthesis by POLH 17 1.94e-01 -0.182000 3.42e-01
Circadian Clock 52 2.36e-02 -0.182000 7.78e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 2.59e-01 -0.181000 4.22e-01
The citric acid (TCA) cycle and respiratory electron transport 121 6.11e-04 -0.181000 5.25e-03
Semaphorin interactions 39 5.11e-02 0.181000 1.36e-01
HATs acetylate histones 63 1.34e-02 -0.180000 4.97e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 158 1.12e-04 -0.178000 1.75e-03
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 29 9.66e-02 0.178000 2.09e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 16 2.18e-01 -0.178000 3.73e-01
L13a-mediated translational silencing of Ceruloplasmin expression 87 4.22e-03 -0.178000 1.92e-02
Miscellaneous transport and binding events 14 2.50e-01 -0.178000 4.13e-01
GPCR ligand binding 80 6.11e-03 0.178000 2.55e-02
Regulation of IFNA/IFNB signaling 12 2.87e-01 -0.177000 4.58e-01
Programmed Cell Death 155 1.45e-04 -0.177000 1.92e-03
Respiratory electron transport 82 5.69e-03 -0.177000 2.43e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects 33 7.92e-02 -0.177000 1.82e-01
Translation of Structural Proteins 27 1.12e-01 -0.177000 2.33e-01
Keratan sulfate biosynthesis 14 2.54e-01 -0.176000 4.18e-01
DAG and IP3 signaling 26 1.20e-01 -0.176000 2.44e-01
Signaling by Hedgehog 99 2.55e-03 -0.176000 1.37e-02
Complex I biogenesis 43 4.67e-02 -0.175000 1.31e-01
Diseases of signal transduction by growth factor receptors and second messengers 299 2.11e-07 -0.175000 1.27e-05
Signalling to RAS 12 2.94e-01 -0.175000 4.66e-01
Extension of Telomeres 44 4.49e-02 -0.175000 1.27e-01
Post-chaperonin tubulin folding pathway 13 2.77e-01 -0.174000 4.45e-01
Aggrephagy 19 1.90e-01 -0.174000 3.36e-01
Switching of origins to a post-replicative state 81 6.94e-03 -0.174000 2.84e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 37 6.76e-02 -0.174000 1.64e-01
Diseases of DNA Double-Strand Break Repair 37 6.76e-02 -0.174000 1.64e-01
Signaling by FGFR 52 3.06e-02 -0.173000 9.32e-02
Sema3A PAK dependent Axon repulsion 11 3.19e-01 0.173000 4.94e-01
ISG15 antiviral mechanism 70 1.24e-02 -0.173000 4.66e-02
ESR-mediated signaling 115 1.38e-03 -0.173000 8.55e-03
DNA Replication 113 1.54e-03 -0.173000 9.07e-03
Activation of BAD and translocation to mitochondria 14 2.64e-01 -0.173000 4.27e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 10 3.45e-01 -0.173000 5.19e-01
Signaling by FLT3 fusion proteins 16 2.33e-01 -0.172000 3.91e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 35 7.82e-02 -0.172000 1.81e-01
SARS-CoV-2-host interactions 150 2.89e-04 -0.172000 3.04e-03
Regulation of TNFR1 signaling 31 9.84e-02 -0.172000 2.12e-01
Peroxisomal lipid metabolism 22 1.64e-01 -0.172000 2.98e-01
Termination of translesion DNA synthesis 28 1.17e-01 -0.171000 2.40e-01
RNA Polymerase II Transcription Termination 45 4.94e-02 -0.169000 1.35e-01
Recognition of DNA damage by PCNA-containing replication complex 26 1.36e-01 -0.169000 2.66e-01
Phase II - Conjugation of compounds 46 4.75e-02 -0.169000 1.31e-01
Activation of BH3-only proteins 27 1.30e-01 -0.169000 2.59e-01
Platelet sensitization by LDL 13 2.93e-01 -0.168000 4.66e-01
Metabolism of vitamins and cofactors 111 2.28e-03 -0.168000 1.24e-02
Signaling by Nuclear Receptors 151 4.00e-04 -0.167000 3.76e-03
Cargo trafficking to the periciliary membrane 40 6.74e-02 -0.167000 1.64e-01
G-protein mediated events 32 1.02e-01 -0.167000 2.16e-01
FLT3 signaling in disease 24 1.56e-01 -0.167000 2.89e-01
Inwardly rectifying K+ channels 13 2.97e-01 0.167000 4.66e-01
Glycosphingolipid metabolism 27 1.34e-01 -0.166000 2.65e-01
CD28 co-stimulation 27 1.34e-01 -0.166000 2.65e-01
Glycogen storage diseases 10 3.62e-01 -0.166000 5.36e-01
Negative epigenetic regulation of rRNA expression 44 5.66e-02 -0.166000 1.47e-01
Disease 1086 1.37e-19 -0.166000 1.65e-16
Metabolism of cofactors 17 2.38e-01 -0.165000 3.97e-01
Disorders of transmembrane transporters 111 2.74e-03 -0.165000 1.43e-02
SUMOylation of RNA binding proteins 42 6.49e-02 -0.165000 1.61e-01
ADP signalling through P2Y purinoceptor 1 16 2.55e-01 0.164000 4.19e-01
HDR through MMEJ (alt-NHEJ) 11 3.45e-01 -0.164000 5.19e-01
Assembly of the pre-replicative complex 76 1.36e-02 -0.164000 5.02e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 41 6.98e-02 -0.164000 1.67e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 41 6.98e-02 -0.164000 1.67e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 41 6.98e-02 -0.164000 1.67e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 41 6.98e-02 -0.164000 1.67e-01
Signaling by NOTCH1 in Cancer 41 6.98e-02 -0.164000 1.67e-01
IKK complex recruitment mediated by RIP1 17 2.43e-01 -0.164000 4.04e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 3.47e-01 -0.164000 5.21e-01
Interleukin-12 family signaling 42 6.74e-02 -0.163000 1.64e-01
HCMV Late Events 51 4.40e-02 -0.163000 1.25e-01
RHO GTPase Effectors 188 1.25e-04 -0.163000 1.75e-03
Post-translational modification: synthesis of GPI-anchored proteins 31 1.17e-01 -0.163000 2.40e-01
MHC class II antigen presentation 69 1.97e-02 -0.163000 6.78e-02
RAC3 GTPase cycle 59 3.09e-02 0.163000 9.33e-02
VxPx cargo-targeting to cilium 16 2.61e-01 -0.162000 4.23e-01
Chaperonin-mediated protein folding 57 3.42e-02 -0.162000 1.01e-01
DNA Replication Pre-Initiation 90 8.13e-03 -0.162000 3.28e-02
Nucleotide catabolism 21 2.00e-01 -0.161000 3.50e-01
Processing of Capped Intron-Containing Pre-mRNA 199 1.00e-04 -0.160000 1.70e-03
Infectious disease 627 1.38e-11 -0.160000 2.77e-09
Regulation of TP53 Activity 136 1.32e-03 -0.160000 8.38e-03
Metabolism of RNA 553 2.04e-10 -0.160000 3.06e-08
DNA Damage Bypass 42 7.35e-02 -0.160000 1.73e-01
Smooth Muscle Contraction 19 2.29e-01 -0.159000 3.87e-01
Metabolism of nucleotides 73 1.87e-02 -0.159000 6.55e-02
Protein folding 63 2.90e-02 -0.159000 9.02e-02
Transcriptional Regulation by TP53 302 2.36e-06 -0.159000 9.15e-05
Factors involved in megakaryocyte development and platelet production 87 1.09e-02 -0.158000 4.19e-02
Energy dependent regulation of mTOR by LKB1-AMPK 25 1.72e-01 -0.158000 3.10e-01
Metabolism of amino acids and derivatives 225 4.88e-05 -0.158000 1.01e-03
Major pathway of rRNA processing in the nucleolus and cytosol 152 8.26e-04 -0.158000 6.49e-03
Role of LAT2/NTAL/LAB on calcium mobilization 10 3.89e-01 -0.157000 5.58e-01
Selective autophagy 50 5.46e-02 -0.157000 1.43e-01
PERK regulates gene expression 26 1.66e-01 -0.157000 3.01e-01
Reproduction 48 6.09e-02 -0.156000 1.53e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 3.48e-01 -0.156000 5.21e-01
Fc epsilon receptor (FCERI) signaling 107 5.30e-03 -0.156000 2.31e-02
Cyclin D associated events in G1 41 8.38e-02 -0.156000 1.90e-01
G1 Phase 41 8.38e-02 -0.156000 1.90e-01
TNF signaling 38 9.63e-02 -0.156000 2.09e-01
p75 NTR receptor-mediated signalling 59 3.84e-02 -0.156000 1.11e-01
E3 ubiquitin ligases ubiquitinate target proteins 41 8.55e-02 -0.155000 1.93e-01
G beta:gamma signalling through BTK 11 3.73e-01 0.155000 5.45e-01
Thromboxane signalling through TP receptor 15 2.99e-01 0.155000 4.68e-01
Epigenetic regulation of gene expression 76 1.97e-02 -0.155000 6.78e-02
TCF dependent signaling in response to WNT 119 3.60e-03 -0.155000 1.74e-02
TNFR2 non-canonical NF-kB pathway 68 2.78e-02 -0.154000 8.73e-02
PLC beta mediated events 29 1.52e-01 -0.154000 2.85e-01
Signaling by EGFR 35 1.15e-01 -0.154000 2.39e-01
ZBP1(DAI) mediated induction of type I IFNs 17 2.74e-01 -0.153000 4.40e-01
Chaperone Mediated Autophagy 12 3.58e-01 -0.153000 5.31e-01
NOTCH1 Intracellular Domain Regulates Transcription 37 1.07e-01 -0.153000 2.26e-01
DNA Damage Recognition in GG-NER 35 1.19e-01 -0.152000 2.43e-01
Transcriptional Regulation by E2F6 29 1.56e-01 -0.152000 2.89e-01
Signaling by CSF3 (G-CSF) 24 1.98e-01 -0.152000 3.47e-01
Interleukin-20 family signaling 13 3.44e-01 -0.152000 5.19e-01
SHC1 events in ERBB2 signaling 11 3.84e-01 0.152000 5.55e-01
Apoptotic factor-mediated response 16 2.95e-01 -0.151000 4.66e-01
Nuclear Events (kinase and transcription factor activation) 42 9.03e-02 -0.151000 1.99e-01
SUMO E3 ligases SUMOylate target proteins 132 2.88e-03 -0.151000 1.48e-02
rRNA processing in the nucleus and cytosol 159 1.09e-03 -0.151000 7.59e-03
Golgi Associated Vesicle Biogenesis 38 1.09e-01 -0.150000 2.28e-01
Regulation of TP53 Degradation 33 1.36e-01 -0.150000 2.66e-01
MyD88-independent TLR4 cascade 74 2.59e-02 -0.150000 8.31e-02
TRIF(TICAM1)-mediated TLR4 signaling 74 2.59e-02 -0.150000 8.31e-02
rRNA processing 164 9.65e-04 -0.150000 7.03e-03
Regulation of TP53 Expression and Degradation 34 1.34e-01 -0.149000 2.65e-01
Deactivation of the beta-catenin transactivating complex 28 1.73e-01 -0.149000 3.11e-01
Activation of G protein gated Potassium channels 12 3.74e-01 0.148000 5.45e-01
G protein gated Potassium channels 12 3.74e-01 0.148000 5.45e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 12 3.74e-01 0.148000 5.45e-01
Toll Like Receptor 4 (TLR4) Cascade 94 1.32e-02 -0.148000 4.91e-02
Interleukin-4 and Interleukin-13 signaling 49 7.41e-02 -0.148000 1.74e-01
Mitochondrial protein import 48 7.74e-02 -0.147000 1.80e-01
Drug ADME 27 1.86e-01 -0.147000 3.32e-01
Plasma lipoprotein clearance 24 2.13e-01 -0.147000 3.67e-01
FOXO-mediated transcription of cell death genes 14 3.42e-01 -0.147000 5.19e-01
Peroxisomal protein import 48 7.90e-02 -0.147000 1.82e-01
ATF4 activates genes in response to endoplasmic reticulum stress 23 2.24e-01 -0.146000 3.80e-01
Protein localization 123 5.17e-03 -0.146000 2.27e-02
SUMOylation of DNA damage response and repair proteins 67 3.94e-02 -0.146000 1.13e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 14 3.46e-01 -0.145000 5.19e-01
Cellular response to starvation 120 6.02e-03 -0.145000 2.53e-02
Signaling by MET 41 1.08e-01 -0.145000 2.27e-01
Interferon alpha/beta signaling 51 7.40e-02 -0.145000 1.74e-01
AKT phosphorylates targets in the cytosol 13 3.67e-01 -0.144000 5.41e-01
Signaling by KIT in disease 16 3.18e-01 -0.144000 4.93e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 16 3.18e-01 -0.144000 4.93e-01
VLDLR internalisation and degradation 11 4.09e-01 -0.144000 5.76e-01
Formation of the ternary complex, and subsequently, the 43S complex 40 1.16e-01 -0.144000 2.39e-01
Interleukin-6 family signaling 13 3.70e-01 -0.144000 5.43e-01
Neddylation 188 7.21e-04 -0.143000 5.80e-03
NoRC negatively regulates rRNA expression 42 1.08e-01 -0.143000 2.27e-01
Signaling by ALK fusions and activated point mutants 46 9.29e-02 -0.143000 2.03e-01
Signaling by ALK in cancer 46 9.29e-02 -0.143000 2.03e-01
ER to Golgi Anterograde Transport 108 1.04e-02 -0.143000 4.03e-02
SARS-CoV-2 Infection 213 3.42e-04 -0.143000 3.37e-03
N-Glycan antennae elongation 10 4.34e-01 -0.143000 6.00e-01
Azathioprine ADME 15 3.40e-01 -0.142000 5.17e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 28 1.92e-01 -0.142000 3.40e-01
Plasma lipoprotein assembly, remodeling, and clearance 39 1.27e-01 -0.141000 2.54e-01
Interleukin-12 signaling 36 1.43e-01 -0.141000 2.74e-01
Metabolism of porphyrins 15 3.45e-01 -0.141000 5.19e-01
Cellular responses to stimuli 551 2.34e-08 -0.141000 2.01e-06
Downstream signaling of activated FGFR1 12 3.99e-01 -0.140000 5.69e-01
Downstream signaling of activated FGFR2 12 3.99e-01 -0.140000 5.69e-01
Downstream signaling of activated FGFR3 12 3.99e-01 -0.140000 5.69e-01
Downstream signaling of activated FGFR4 12 3.99e-01 -0.140000 5.69e-01
TP53 Regulates Metabolic Genes 71 4.11e-02 -0.140000 1.17e-01
MET promotes cell motility 13 3.82e-01 -0.140000 5.53e-01
Antiviral mechanism by IFN-stimulated genes 77 3.43e-02 -0.140000 1.01e-01
RAS processing 15 3.49e-01 -0.140000 5.21e-01
Signaling by NOTCH 135 5.27e-03 -0.139000 2.30e-02
SUMOylation 138 4.84e-03 -0.139000 2.16e-02
Death Receptor Signalling 96 1.86e-02 -0.139000 6.54e-02
Cellular responses to stress 546 3.64e-08 -0.139000 2.80e-06
Condensation of Prophase Chromosomes 12 4.04e-01 -0.139000 5.73e-01
Mitochondrial translation 89 2.38e-02 -0.139000 7.85e-02
Transport to the Golgi and subsequent modification 130 6.69e-03 -0.138000 2.76e-02
mRNA Splicing - Major Pathway 148 3.88e-03 -0.138000 1.82e-02
MyD88 dependent cascade initiated on endosome 67 5.13e-02 -0.138000 1.36e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 67 5.13e-02 -0.138000 1.36e-01
Regulation of beta-cell development 16 3.42e-01 -0.137000 5.19e-01
mRNA 3’-end processing 37 1.49e-01 -0.137000 2.84e-01
DNA Double Strand Break Response 36 1.56e-01 -0.137000 2.89e-01
Nuclear Envelope (NE) Reassembly 60 6.75e-02 -0.137000 1.64e-01
N-glycan antennae elongation in the medial/trans-Golgi 17 3.32e-01 -0.136000 5.07e-01
MyD88 cascade initiated on plasma membrane 65 5.83e-02 -0.136000 1.49e-01
Toll Like Receptor 10 (TLR10) Cascade 65 5.83e-02 -0.136000 1.49e-01
Toll Like Receptor 5 (TLR5) Cascade 65 5.83e-02 -0.136000 1.49e-01
Platelet degranulation 49 1.01e-01 -0.135000 2.16e-01
Regulation of HSF1-mediated heat shock response 67 5.63e-02 -0.135000 1.47e-01
Gene expression (Transcription) 1040 5.89e-13 -0.135000 1.42e-10
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 14 3.86e-01 -0.134000 5.58e-01
Resolution of D-Loop Structures 29 2.14e-01 -0.133000 3.68e-01
Molecules associated with elastic fibres 12 4.24e-01 0.133000 5.91e-01
Assembly of collagen fibrils and other multimeric structures 14 3.87e-01 0.133000 5.58e-01
mRNA Splicing 158 3.90e-03 -0.133000 1.82e-02
PRC2 methylates histones and DNA 12 4.24e-01 -0.133000 5.91e-01
Deadenylation-dependent mRNA decay 52 9.71e-02 -0.133000 2.10e-01
Class I MHC mediated antigen processing & presentation 289 1.12e-04 -0.133000 1.75e-03
Kinesins 32 1.95e-01 -0.133000 3.42e-01
Toll Like Receptor 3 (TLR3) Cascade 74 4.92e-02 -0.132000 1.35e-01
RHOG GTPase cycle 49 1.09e-01 0.132000 2.28e-01
Heme biosynthesis 10 4.69e-01 -0.132000 6.31e-01
Response to elevated platelet cytosolic Ca2+ 53 9.74e-02 -0.132000 2.10e-01
Metabolism of proteins 1246 2.53e-14 -0.131000 1.52e-11
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 24 2.66e-01 -0.131000 4.30e-01
RMTs methylate histone arginines 25 2.59e-01 -0.131000 4.22e-01
Signaling by NOTCH3 30 2.16e-01 -0.131000 3.71e-01
RHOF GTPase cycle 25 2.60e-01 0.130000 4.23e-01
Metabolism 1253 4.19e-14 -0.130000 1.68e-11
Signaling by ERBB2 TMD/JMD mutants 10 4.78e-01 -0.129000 6.37e-01
Diseases of metabolism 126 1.24e-02 -0.129000 4.66e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity 12 4.39e-01 0.129000 6.02e-01
Trafficking of AMPA receptors 12 4.39e-01 0.129000 6.02e-01
STING mediated induction of host immune responses 10 4.80e-01 0.129000 6.39e-01
Nephrin family interactions 14 4.05e-01 -0.129000 5.73e-01
SARS-CoV Infections 270 3.18e-04 -0.128000 3.27e-03
Negative regulation of NMDA receptor-mediated neuronal transmission 12 4.43e-01 0.128000 6.04e-01
ER Quality Control Compartment (ERQC) 18 3.48e-01 0.128000 5.21e-01
Ca-dependent events 21 3.13e-01 -0.127000 4.87e-01
NGF-stimulated transcription 25 2.71e-01 -0.127000 4.38e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 66 7.57e-02 -0.127000 1.77e-01
Generic Transcription Pathway 826 1.35e-09 -0.126000 1.47e-07
Asparagine N-linked glycosylation 225 1.17e-03 -0.126000 7.75e-03
Mitochondrial translation termination 83 4.75e-02 -0.126000 1.31e-01
BBSome-mediated cargo-targeting to cilium 19 3.42e-01 -0.126000 5.19e-01
Glucagon-type ligand receptors 14 4.16e-01 0.126000 5.82e-01
Mitochondrial translation initiation 84 4.71e-02 -0.125000 1.31e-01
Interferon Signaling 142 1.02e-02 -0.125000 3.96e-02
Cholesterol biosynthesis 22 3.10e-01 -0.125000 4.84e-01
Cell death signalling via NRAGE, NRIF and NADE 45 1.50e-01 -0.124000 2.84e-01
Diseases of carbohydrate metabolism 23 3.03e-01 -0.124000 4.73e-01
Nicotinamide salvaging 11 4.76e-01 0.124000 6.36e-01
tRNA modification in the nucleus and cytosol 34 2.11e-01 -0.124000 3.64e-01
Branched-chain amino acid catabolism 20 3.37e-01 -0.124000 5.14e-01
SUMOylation of transcription factors 13 4.39e-01 -0.124000 6.02e-01
PTEN Regulation 115 2.20e-02 -0.124000 7.40e-02
Metabolism of steroids 86 4.76e-02 -0.124000 1.31e-01
Metal ion SLC transporters 16 3.92e-01 -0.124000 5.60e-01
Meiotic synapsis 25 2.84e-01 -0.124000 4.54e-01
Ribosomal scanning and start codon recognition 47 1.43e-01 -0.123000 2.74e-01
Antigen processing: Ubiquitination & Proteasome degradation 241 1.01e-03 -0.123000 7.23e-03
DAP12 interactions 21 3.28e-01 -0.123000 5.04e-01
Signaling by WNT 177 4.96e-03 -0.123000 2.20e-02
Aquaporin-mediated transport 25 2.89e-01 0.123000 4.59e-01
RNA Polymerase II Transcription 927 5.42e-10 -0.122000 7.24e-08
Translation initiation complex formation 47 1.47e-01 -0.122000 2.81e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 35 2.11e-01 -0.122000 3.64e-01
Negative regulation of MAPK pathway 36 2.06e-01 -0.122000 3.58e-01
Signaling by WNT in cancer 23 3.12e-01 -0.122000 4.86e-01
Beta-catenin independent WNT signaling 106 3.21e-02 -0.121000 9.59e-02
SARS-CoV-2 modulates host translation machinery 39 1.93e-01 -0.121000 3.40e-01
Post-translational protein modification 917 1.26e-09 -0.120000 1.47e-07
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 22 3.29e-01 -0.120000 5.04e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 22 3.29e-01 -0.120000 5.04e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 22 3.29e-01 -0.120000 5.04e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 22 3.29e-01 -0.120000 5.04e-01
Impaired BRCA2 binding to PALB2 22 3.29e-01 -0.120000 5.04e-01
RIP-mediated NFkB activation via ZBP1 14 4.36e-01 -0.120000 6.01e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 61 1.05e-01 -0.120000 2.22e-01
Synthesis of PA 18 3.78e-01 0.120000 5.50e-01
CaM pathway 20 3.53e-01 -0.120000 5.25e-01
Calmodulin induced events 20 3.53e-01 -0.120000 5.25e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 27 2.82e-01 -0.120000 4.52e-01
Pexophagy 11 4.92e-01 -0.120000 6.45e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 35 2.21e-01 0.120000 3.77e-01
MTOR signalling 36 2.15e-01 -0.119000 3.69e-01
Signaling by NOTCH1 51 1.41e-01 -0.119000 2.70e-01
Cellular response to heat stress 80 6.53e-02 -0.119000 1.62e-01
Non-integrin membrane-ECM interactions 14 4.42e-01 0.119000 6.04e-01
Cell junction organization 26 2.96e-01 0.118000 4.66e-01
The phototransduction cascade 18 3.86e-01 0.118000 5.57e-01
Diseases of glycosylation 69 9.01e-02 -0.118000 1.99e-01
Activation of ATR in response to replication stress 36 2.21e-01 -0.118000 3.76e-01
Signaling by NTRK1 (TRKA) 79 7.01e-02 -0.118000 1.67e-01
Transcriptional activation of mitochondrial biogenesis 40 1.99e-01 -0.117000 3.48e-01
Regulation of TP53 Activity through Acetylation 27 2.93e-01 -0.117000 4.66e-01
Adrenaline,noradrenaline inhibits insulin secretion 15 4.33e-01 0.117000 6.00e-01
PKMTs methylate histone lysines 31 2.61e-01 0.117000 4.23e-01
KSRP (KHSRP) binds and destabilizes mRNA 15 4.34e-01 -0.117000 6.00e-01
FCGR3A-mediated IL10 synthesis 22 3.44e-01 -0.117000 5.19e-01
Inactivation of CSF3 (G-CSF) signaling 19 3.80e-01 -0.116000 5.50e-01
TCR signaling 87 6.09e-02 -0.116000 1.53e-01
Ion transport by P-type ATPases 27 2.96e-01 -0.116000 4.66e-01
Signaling by ERBB4 31 2.64e-01 -0.116000 4.28e-01
Extra-nuclear estrogen signaling 49 1.62e-01 -0.116000 2.96e-01
VEGFA-VEGFR2 Pathway 71 9.29e-02 -0.115000 2.03e-01
MAPK family signaling cascades 191 6.11e-03 -0.115000 2.55e-02
RND1 GTPase cycle 29 2.82e-01 -0.115000 4.52e-01
Vesicle-mediated transport 454 2.94e-05 -0.115000 7.37e-04
trans-Golgi Network Vesicle Budding 51 1.55e-01 -0.115000 2.88e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 48 1.68e-01 -0.115000 3.03e-01
MAPK1/MAPK3 signaling 164 1.17e-02 -0.114000 4.47e-02
Collagen biosynthesis and modifying enzymes 19 3.89e-01 0.114000 5.58e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 5.15e-01 -0.113000 6.57e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 4.64e-01 -0.113000 6.25e-01
RHOV GTPase cycle 28 3.01e-01 -0.113000 4.70e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 4.98e-01 -0.113000 6.48e-01
Toll Like Receptor 9 (TLR9) Cascade 70 1.03e-01 -0.113000 2.18e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 29 2.95e-01 -0.112000 4.66e-01
Interferon gamma signaling 55 1.50e-01 -0.112000 2.84e-01
Signaling by PDGF 25 3.33e-01 -0.112000 5.08e-01
G alpha (q) signalling events 78 8.83e-02 0.112000 1.98e-01
Membrane binding and targetting of GAG proteins 12 5.03e-01 -0.112000 6.51e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 5.03e-01 -0.112000 6.51e-01
Membrane Trafficking 446 6.95e-05 -0.111000 1.35e-03
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 22 3.69e-01 -0.111000 5.43e-01
Fcgamma receptor (FCGR) dependent phagocytosis 62 1.34e-01 -0.110000 2.65e-01
Signaling by cytosolic FGFR1 fusion mutants 16 4.46e-01 -0.110000 6.06e-01
ECM proteoglycans 13 4.93e-01 0.110000 6.46e-01
G alpha (z) signalling events 25 3.43e-01 0.110000 5.19e-01
Signaling by Hippo 12 5.12e-01 -0.109000 6.55e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 10 5.50e-01 -0.109000 6.84e-01
Toll-like Receptor Cascades 108 5.07e-02 -0.109000 1.36e-01
VEGFR2 mediated vascular permeability 21 3.88e-01 -0.109000 5.58e-01
Interleukin receptor SHC signaling 15 4.69e-01 -0.108000 6.31e-01
Intracellular signaling by second messengers 210 7.26e-03 -0.108000 2.96e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 4.70e-01 -0.108000 6.31e-01
Signaling by Activin 12 5.20e-01 0.107000 6.61e-01
Hyaluronan uptake and degradation 10 5.57e-01 -0.107000 6.89e-01
Ras activation upon Ca2+ influx through NMDA receptor 10 5.57e-01 0.107000 6.89e-01
SUMOylation of DNA methylation proteins 14 4.88e-01 0.107000 6.42e-01
EPHB-mediated forward signaling 25 3.55e-01 -0.107000 5.28e-01
Fatty acid metabolism 104 6.03e-02 -0.107000 1.53e-01
Mitochondrial translation elongation 84 9.17e-02 -0.107000 2.02e-01
EGFR downregulation 20 4.09e-01 -0.107000 5.76e-01
RND2 GTPase cycle 34 2.84e-01 -0.106000 4.53e-01
Caspase activation via extrinsic apoptotic signalling pathway 15 4.76e-01 -0.106000 6.36e-01
RHO GTPases activate PAKs 13 5.07e-01 -0.106000 6.53e-01
Listeria monocytogenes entry into host cells 14 4.95e-01 -0.105000 6.47e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 21 4.04e-01 -0.105000 5.73e-01
Signaling by NTRKs 87 9.01e-02 -0.105000 1.99e-01
Signaling by Interleukins 265 3.35e-03 -0.105000 1.67e-02
NOTCH4 Intracellular Domain Regulates Transcription 14 4.96e-01 -0.105000 6.47e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 12 5.29e-01 0.105000 6.67e-01
Signaling by VEGF 73 1.23e-01 -0.105000 2.48e-01
SUMOylation of chromatin organization proteins 49 2.07e-01 -0.104000 3.59e-01
G alpha (i) signalling events 93 8.39e-02 0.104000 1.90e-01
O-linked glycosylation 42 2.44e-01 0.104000 4.07e-01
HDACs deacetylate histones 28 3.43e-01 -0.104000 5.19e-01
Synthesis of very long-chain fatty acyl-CoAs 16 4.73e-01 0.104000 6.34e-01
Unfolded Protein Response (UPR) 76 1.20e-01 -0.103000 2.43e-01
SLC transporter disorders 52 1.99e-01 -0.103000 3.48e-01
Nuclear Envelope Breakdown 49 2.12e-01 -0.103000 3.66e-01
Protein ubiquitination 59 1.72e-01 -0.103000 3.10e-01
Metabolism of fat-soluble vitamins 13 5.21e-01 -0.103000 6.61e-01
Josephin domain DUBs 11 5.56e-01 -0.103000 6.89e-01
Mitophagy 25 3.79e-01 -0.102000 5.50e-01
HSF1 activation 21 4.23e-01 -0.101000 5.91e-01
Signaling by ERBB2 in Cancer 13 5.29e-01 -0.101000 6.67e-01
Assembly and cell surface presentation of NMDA receptors 13 5.29e-01 0.101000 6.67e-01
RAF/MAP kinase cascade 159 2.98e-02 -0.100000 9.15e-02
Fatty acyl-CoA biosynthesis 26 3.77e-01 -0.100000 5.49e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 27 3.70e-01 -0.099800 5.43e-01
Potential therapeutics for SARS 66 1.62e-01 -0.099600 2.96e-01
Cytochrome P450 - arranged by substrate type 14 5.19e-01 0.099500 6.61e-01
Gastrin-CREB signalling pathway via PKC and MAPK 11 5.68e-01 -0.099300 6.98e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 71 1.51e-01 -0.098800 2.84e-01
Toll Like Receptor 2 (TLR2) Cascade 71 1.51e-01 -0.098800 2.84e-01
Toll Like Receptor TLR1:TLR2 Cascade 71 1.51e-01 -0.098800 2.84e-01
Toll Like Receptor TLR6:TLR2 Cascade 71 1.51e-01 -0.098800 2.84e-01
PKA-mediated phosphorylation of CREB 11 5.71e-01 -0.098600 6.99e-01
Other interleukin signaling 15 5.09e-01 -0.098600 6.53e-01
Signaling by Receptor Tyrosine Kinases 293 3.89e-03 -0.098500 1.82e-02
Activation of kainate receptors upon glutamate binding 17 4.82e-01 0.098400 6.40e-01
Adaptive Immune System 481 2.55e-04 -0.098200 2.76e-03
PIP3 activates AKT signaling 185 2.22e-02 -0.097800 7.46e-02
SARS-CoV-1 Infection 46 2.54e-01 -0.097300 4.18e-01
TAK1-dependent IKK and NF-kappa-B activation 18 4.76e-01 -0.097000 6.36e-01
Transcriptional regulation of white adipocyte differentiation 56 2.11e-01 -0.096700 3.64e-01
Intra-Golgi traffic 39 2.96e-01 -0.096700 4.66e-01
Diseases associated with the TLR signaling cascade 17 4.91e-01 -0.096600 6.44e-01
Diseases of Immune System 17 4.91e-01 -0.096600 6.44e-01
Synthesis of PC 22 4.34e-01 -0.096400 6.00e-01
G beta:gamma signalling through PLC beta 13 5.47e-01 0.096400 6.82e-01
Presynaptic function of Kainate receptors 13 5.47e-01 0.096400 6.82e-01
FOXO-mediated transcription 46 2.58e-01 -0.096400 4.22e-01
Macroautophagy 97 1.02e-01 -0.096200 2.17e-01
Formation of the beta-catenin:TCF transactivating complex 25 4.05e-01 -0.096200 5.73e-01
PKA activation 10 6.01e-01 -0.095500 7.27e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 14 5.36e-01 -0.095500 6.71e-01
EPH-ephrin mediated repulsion of cells 25 4.09e-01 -0.095400 5.76e-01
RET signaling 23 4.29e-01 -0.095400 5.96e-01
Pyroptosis 18 4.88e-01 -0.094400 6.42e-01
Cytokine Signaling in Immune system 427 9.13e-04 -0.094300 6.81e-03
Post-translational protein phosphorylation 34 3.45e-01 0.093700 5.19e-01
Mitotic Prophase 75 1.61e-01 -0.093600 2.96e-01
ADP signalling through P2Y purinoceptor 12 13 5.66e-01 0.092000 6.97e-01
Signaling by ERBB2 33 3.61e-01 -0.092000 5.34e-01
Axon guidance 300 6.73e-03 -0.091400 2.77e-02
Cytosolic sensors of pathogen-associated DNA 53 2.51e-01 -0.091200 4.15e-01
Oncogene Induced Senescence 30 3.89e-01 -0.090800 5.58e-01
PI3K/AKT Signaling in Cancer 52 2.59e-01 -0.090600 4.22e-01
Autophagy 106 1.09e-01 -0.090400 2.27e-01
Activation of GABAB receptors 18 5.08e-01 0.090200 6.53e-01
GABA B receptor activation 18 5.08e-01 0.090200 6.53e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 10 6.23e-01 -0.089900 7.47e-01
GPCR downstream signalling 197 3.04e-02 0.089800 9.28e-02
Mucopolysaccharidoses 10 6.24e-01 -0.089600 7.47e-01
G alpha (12/13) signalling events 40 3.28e-01 0.089500 5.04e-01
HDMs demethylate histones 15 5.49e-01 -0.089300 6.84e-01
Signaling by Erythropoietin 19 5.02e-01 -0.089100 6.50e-01
Signaling by BMP 15 5.51e-01 0.089000 6.85e-01
TICAM1, RIP1-mediated IKK complex recruitment 17 5.27e-01 -0.088700 6.67e-01
Glutamate Neurotransmitter Release Cycle 12 5.96e-01 0.088400 7.24e-01
CDC42 GTPase cycle 97 1.34e-01 0.088100 2.65e-01
DARPP-32 events 21 4.86e-01 -0.087900 6.42e-01
PINK1-PRKN Mediated Mitophagy 20 4.99e-01 -0.087300 6.48e-01
Signalling to ERKs 25 4.52e-01 -0.087000 6.13e-01
Chromatin modifying enzymes 158 6.11e-02 -0.086600 1.53e-01
Chromatin organization 158 6.11e-02 -0.086600 1.53e-01
Nervous system development 313 8.89e-03 -0.086500 3.53e-02
Cargo recognition for clathrin-mediated endocytosis 63 2.37e-01 -0.086100 3.97e-01
Synthesis of substrates in N-glycan biosythesis 48 3.06e-01 -0.085400 4.78e-01
Signaling by NODAL 12 6.09e-01 0.085200 7.35e-01
The role of Nef in HIV-1 replication and disease pathogenesis 19 5.21e-01 0.085000 6.61e-01
RAC2 GTPase cycle 56 2.72e-01 0.084800 4.39e-01
RHOH GTPase cycle 29 4.30e-01 0.084600 5.97e-01
Interleukin-15 signaling 11 6.28e-01 -0.084300 7.49e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 23 4.84e-01 0.084200 6.42e-01
Cellular Senescence 106 1.42e-01 -0.082700 2.72e-01
Insulin processing 17 5.56e-01 -0.082500 6.89e-01
GPVI-mediated activation cascade 23 4.96e-01 -0.082100 6.47e-01
RHO GTPases Activate WASPs and WAVEs 29 4.45e-01 -0.082000 6.05e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 24 4.88e-01 0.081700 6.42e-01
Pre-NOTCH Processing in Golgi 16 5.72e-01 -0.081500 6.99e-01
Activation of NMDA receptors and postsynaptic events 44 3.50e-01 -0.081500 5.22e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 4.27e-01 -0.081200 5.94e-01
Iron uptake and transport 38 3.89e-01 -0.080800 5.58e-01
HSF1-dependent transactivation 25 4.85e-01 -0.080700 6.42e-01
Extracellular matrix organization 93 1.80e-01 0.080600 3.21e-01
Collagen formation 28 4.60e-01 0.080600 6.21e-01
MAP2K and MAPK activation 25 4.86e-01 0.080500 6.42e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 31 4.40e-01 0.080200 6.02e-01
Integrin signaling 16 5.82e-01 -0.079400 7.09e-01
Platelet Aggregation (Plug Formation) 16 5.82e-01 -0.079400 7.09e-01
Senescence-Associated Secretory Phenotype (SASP) 42 3.74e-01 -0.079400 5.45e-01
Innate Immune System 620 8.63e-04 -0.079300 6.56e-03
Deadenylation of mRNA 23 5.11e-01 -0.079200 6.55e-01
Signaling by GPCR 216 4.68e-02 0.078800 1.31e-01
Inositol phosphate metabolism 30 4.57e-01 -0.078600 6.17e-01
APC-Cdc20 mediated degradation of Nek2A 24 5.06e-01 -0.078400 6.53e-01
Metabolism of steroid hormones 13 6.26e-01 -0.078100 7.48e-01
EPH-Ephrin signaling 55 3.17e-01 -0.078000 4.92e-01
Regulation of signaling by CBL 14 6.13e-01 -0.078000 7.38e-01
Intraflagellar transport 33 4.40e-01 -0.077800 6.02e-01
Mitochondrial calcium ion transport 19 5.58e-01 -0.077600 6.89e-01
Signaling by TGF-beta Receptor Complex 72 2.55e-01 -0.077600 4.19e-01
Apoptotic execution phase 33 4.41e-01 -0.077500 6.03e-01
RAC1 GTPase cycle 110 1.62e-01 0.077400 2.96e-01
NCAM signaling for neurite out-growth 24 5.14e-01 0.077000 6.57e-01
RHOBTB GTPase Cycle 29 4.79e-01 -0.076000 6.37e-01
Cell surface interactions at the vascular wall 56 3.27e-01 0.075900 5.04e-01
Biological oxidations 79 2.46e-01 -0.075600 4.08e-01
Cytochrome c-mediated apoptotic response 11 6.66e-01 -0.075200 7.80e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 26 5.07e-01 -0.075200 6.53e-01
Recycling pathway of L1 15 6.15e-01 -0.074900 7.39e-01
FCERI mediated Ca+2 mobilization 23 5.36e-01 -0.074600 6.71e-01
Developmental Biology 468 6.13e-03 -0.074600 2.55e-02
Class B/2 (Secretin family receptors) 29 4.88e-01 0.074500 6.42e-01
Interleukin-10 signaling 13 6.43e-01 -0.074300 7.61e-01
Inactivation, recovery and regulation of the phototransduction cascade 17 5.98e-01 0.073800 7.25e-01
Clathrin-mediated endocytosis 89 2.33e-01 -0.073200 3.91e-01
Insulin receptor signalling cascade 26 5.19e-01 0.073000 6.61e-01
Sphingolipid metabolism 49 3.79e-01 -0.072700 5.50e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 29 5.00e-01 -0.072400 6.48e-01
Stimuli-sensing channels 39 4.34e-01 0.072400 6.00e-01
mRNA decay by 3’ to 5’ exoribonuclease 14 6.39e-01 -0.072300 7.59e-01
Signaling by Non-Receptor Tyrosine Kinases 36 4.53e-01 -0.072300 6.13e-01
Signaling by PTK6 36 4.53e-01 -0.072300 6.13e-01
MAPK targets/ Nuclear events mediated by MAP kinases 23 5.54e-01 -0.071300 6.88e-01
Signal Transduction 1356 1.91e-05 -0.071100 5.45e-04
Response of EIF2AK1 (HRI) to heme deficiency 14 6.46e-01 -0.070900 7.63e-01
Regulation of FZD by ubiquitination 12 6.71e-01 0.070700 7.83e-01
Sialic acid metabolism 23 5.59e-01 -0.070400 6.89e-01
Fanconi Anemia Pathway 31 4.98e-01 -0.070400 6.48e-01
SUMOylation of transcription cofactors 35 4.72e-01 -0.070200 6.34e-01
G alpha (s) signalling events 48 4.01e-01 0.070200 5.70e-01
Oncogenic MAPK signaling 56 3.68e-01 -0.069500 5.43e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 39 4.53e-01 -0.069400 6.13e-01
Hyaluronan metabolism 11 6.91e-01 -0.069300 8.00e-01
Immune System 1156 1.14e-04 -0.068900 1.75e-03
APC/C:Cdc20 mediated degradation of Cyclin B 22 5.77e-01 -0.068700 7.04e-01
Peptide hormone metabolism 31 5.09e-01 0.068500 6.53e-01
Activated NOTCH1 Transmits Signal to the Nucleus 19 6.10e-01 -0.067700 7.35e-01
Regulation of innate immune responses to cytosolic DNA 12 6.87e-01 0.067100 7.97e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 29 5.33e-01 -0.066900 6.70e-01
Signaling by RAS mutants 29 5.33e-01 -0.066900 6.70e-01
Signaling by moderate kinase activity BRAF mutants 29 5.33e-01 -0.066900 6.70e-01
Signaling downstream of RAS mutants 29 5.33e-01 -0.066900 6.70e-01
Costimulation by the CD28 family 44 4.43e-01 -0.066800 6.04e-01
Signaling by FGFR1 in disease 24 5.73e-01 -0.066600 6.99e-01
Vasopressin regulates renal water homeostasis via Aquaporins 23 5.83e-01 0.066100 7.10e-01
Post NMDA receptor activation events 38 4.82e-01 -0.065900 6.40e-01
GPER1 signaling 25 5.69e-01 0.065900 6.98e-01
RHOQ GTPase cycle 39 4.79e-01 0.065600 6.37e-01
Interleukin-37 signaling 17 6.42e-01 0.065100 7.61e-01
Signaling by Leptin 10 7.24e-01 0.064500 8.25e-01
Attenuation phase 19 6.29e-01 -0.063900 7.49e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 449 2.30e-02 -0.063100 7.66e-02
Nicotinate metabolism 19 6.36e-01 0.062800 7.55e-01
Signal amplification 20 6.30e-01 0.062300 7.49e-01
RAF activation 28 5.70e-01 -0.062100 6.99e-01
Neutrophil degranulation 307 6.32e-02 -0.062000 1.58e-01
Integration of energy metabolism 60 4.12e-01 -0.061300 5.77e-01
Signaling by Rho GTPases 437 2.95e-02 -0.061200 9.10e-02
DCC mediated attractive signaling 11 7.26e-01 0.061100 8.25e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 16 6.73e-01 0.061000 7.83e-01
Transport of small molecules 359 4.86e-02 -0.061000 1.34e-01
L1CAM interactions 41 5.00e-01 -0.061000 6.48e-01
Cytosolic sulfonation of small molecules 10 7.39e-01 -0.060900 8.35e-01
Metabolism of lipids 439 3.06e-02 -0.060700 9.32e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 14 6.96e-01 0.060300 8.04e-01
XBP1(S) activates chaperone genes 42 5.00e-01 -0.060200 6.48e-01
FGFR1 mutant receptor activation 20 6.45e-01 -0.059500 7.63e-01
Cargo concentration in the ER 20 6.48e-01 -0.058900 7.65e-01
Bile acid and bile salt metabolism 15 6.95e-01 0.058400 8.04e-01
GABA receptor activation 19 6.61e-01 0.058100 7.77e-01
A tetrasaccharide linker sequence is required for GAG synthesis 10 7.51e-01 0.057900 8.47e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 6.63e-01 -0.057800 7.77e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 6.63e-01 -0.057800 7.77e-01
CTLA4 inhibitory signaling 16 6.91e-01 0.057500 8.00e-01
Amino acids regulate mTORC1 42 5.20e-01 -0.057400 6.61e-01
Opioid Signalling 58 4.50e-01 -0.057400 6.12e-01
Transport of vitamins, nucleosides, and related molecules 21 6.49e-01 -0.057300 7.65e-01
Glycosaminoglycan metabolism 64 4.30e-01 -0.057100 5.97e-01
NOTCH3 Intracellular Domain Regulates Transcription 15 7.03e-01 -0.056900 8.08e-01
Nonhomologous End-Joining (NHEJ) 29 5.96e-01 -0.056900 7.24e-01
Signaling by TGFB family members 85 3.66e-01 -0.056800 5.40e-01
Regulation of KIT signaling 10 7.57e-01 0.056600 8.51e-01
Assembly Of The HIV Virion 14 7.15e-01 -0.056300 8.20e-01
Regulation of actin dynamics for phagocytic cup formation 44 5.21e-01 -0.056000 6.61e-01
Netrin-1 signaling 25 6.29e-01 0.055900 7.49e-01
IRE1alpha activates chaperones 43 5.29e-01 -0.055600 6.67e-01
Phase I - Functionalization of compounds 30 6.00e-01 0.055400 7.26e-01
NOD1/2 Signaling Pathway 23 6.46e-01 0.055300 7.63e-01
RHOA GTPase cycle 93 3.59e-01 0.055100 5.32e-01
Heparan sulfate/heparin (HS-GAG) metabolism 22 6.59e-01 -0.054400 7.75e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 27 6.25e-01 -0.054300 7.48e-01
RHOJ GTPase cycle 37 5.72e-01 0.053700 6.99e-01
Ca2+ pathway 40 5.59e-01 -0.053500 6.89e-01
Gap junction trafficking 10 7.71e-01 0.053200 8.61e-01
PPARA activates gene expression 82 4.10e-01 -0.052700 5.77e-01
Gap junction trafficking and regulation 11 7.64e-01 0.052400 8.56e-01
Signaling by SCF-KIT 32 6.10e-01 -0.052100 7.35e-01
Nuclear signaling by ERBB4 16 7.19e-01 -0.052000 8.20e-01
Activation of the pre-replicative complex 30 6.28e-01 -0.051100 7.49e-01
Signaling by BRAF and RAF1 fusions 42 5.68e-01 -0.051000 6.98e-01
Insulin receptor recycling 17 7.17e-01 -0.050800 8.20e-01
Frs2-mediated activation 11 7.72e-01 0.050500 8.61e-01
Transferrin endocytosis and recycling 19 7.04e-01 -0.050300 8.09e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 7.14e-01 -0.049900 8.20e-01
COPII-mediated vesicle transport 51 5.38e-01 -0.049800 6.73e-01
Regulation of lipid metabolism by PPARalpha 84 4.36e-01 -0.049200 6.01e-01
Rab regulation of trafficking 94 4.11e-01 -0.049100 5.77e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 16 7.34e-01 -0.049000 8.32e-01
Downregulation of TGF-beta receptor signaling 26 6.68e-01 -0.048600 7.80e-01
G-protein beta:gamma signalling 21 7.02e-01 -0.048300 8.08e-01
Effects of PIP2 hydrolysis 19 7.16e-01 0.048200 8.20e-01
IGF1R signaling cascade 23 6.98e-01 -0.046800 8.04e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 23 6.98e-01 -0.046800 8.04e-01
Basigin interactions 14 7.62e-01 0.046800 8.55e-01
RHOBTB2 GTPase cycle 20 7.18e-01 -0.046700 8.20e-01
Telomere Extension By Telomerase 20 7.22e-01 -0.046000 8.23e-01
Transcriptional regulation of granulopoiesis 25 6.92e-01 0.045800 8.00e-01
Cardiac conduction 43 6.04e-01 0.045800 7.29e-01
RHOBTB1 GTPase cycle 18 7.37e-01 -0.045700 8.34e-01
Transcriptional Regulation by VENTX 30 6.68e-01 0.045300 7.80e-01
RAB GEFs exchange GTP for GDP on RABs 64 5.35e-01 0.044900 6.70e-01
Hemostasis 304 1.85e-01 -0.044400 3.30e-01
RHO GTPases Activate NADPH Oxidases 14 7.74e-01 -0.044200 8.61e-01
RHOU GTPase cycle 32 6.67e-01 -0.044000 7.80e-01
Erythropoietin activates RAS 10 8.11e-01 -0.043700 8.89e-01
Platelet homeostasis 49 5.99e-01 -0.043500 7.25e-01
G beta:gamma signalling through CDC42 13 7.87e-01 0.043300 8.70e-01
Sphingolipid de novo biosynthesis 22 7.29e-01 0.042600 8.27e-01
Cell recruitment (pro-inflammatory response) 15 7.78e-01 0.042100 8.63e-01
Purinergic signaling in leishmaniasis infection 15 7.78e-01 0.042100 8.63e-01
Platelet activation, signaling and aggregation 132 4.05e-01 -0.042000 5.73e-01
Metalloprotease DUBs 17 7.65e-01 -0.041900 8.56e-01
Glycerophospholipid biosynthesis 74 5.35e-01 -0.041800 6.70e-01
activated TAK1 mediates p38 MAPK activation 13 7.95e-01 0.041500 8.75e-01
Neuronal System 139 4.04e-01 0.041100 5.73e-01
Transcriptional regulation by RUNX1 137 4.11e-01 -0.040800 5.77e-01
Retinoid metabolism and transport 11 8.15e-01 -0.040700 8.91e-01
Initiation of Nuclear Envelope (NE) Reformation 17 7.73e-01 -0.040500 8.61e-01
Signal transduction by L1 11 8.17e-01 -0.040300 8.91e-01
Neurotransmitter release cycle 20 7.61e-01 -0.039300 8.55e-01
Sensory processing of sound by outer hair cells of the cochlea 18 7.74e-01 -0.039100 8.61e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 45 6.51e-01 -0.039000 7.67e-01
Negative regulation of FLT3 13 8.10e-01 0.038600 8.89e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 23 7.49e-01 0.038500 8.46e-01
IRS-related events triggered by IGF1R 22 7.59e-01 -0.037800 8.53e-01
Glucagon signaling in metabolic regulation 18 7.83e-01 0.037500 8.68e-01
Suppression of phagosomal maturation 12 8.27e-01 0.036500 9.00e-01
FCERI mediated MAPK activation 23 7.66e-01 0.035900 8.56e-01
DAP12 signaling 19 7.88e-01 -0.035600 8.71e-01
Muscle contraction 67 6.15e-01 -0.035600 7.39e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 7.50e-01 0.035500 8.46e-01
Caspase-mediated cleavage of cytoskeletal proteins 10 8.46e-01 0.035500 9.18e-01
Visual phototransduction 34 7.25e-01 0.034900 8.25e-01
G beta:gamma signalling through PI3Kgamma 17 8.06e-01 0.034400 8.85e-01
MAP kinase activation 49 6.81e-01 -0.034000 7.90e-01
Anti-inflammatory response favouring Leishmania parasite infection 54 6.80e-01 -0.032500 7.90e-01
Leishmania parasite growth and survival 54 6.80e-01 -0.032500 7.90e-01
Negative regulation of FGFR1 signaling 18 8.17e-01 0.031500 8.91e-01
Negative regulation of FGFR2 signaling 18 8.17e-01 0.031500 8.91e-01
Negative regulation of FGFR3 signaling 18 8.17e-01 0.031500 8.91e-01
Negative regulation of FGFR4 signaling 18 8.17e-01 0.031500 8.91e-01
Regulation of MECP2 expression and activity 23 7.95e-01 0.031300 8.75e-01
Plasma lipoprotein remodeling 11 8.60e-01 -0.030700 9.28e-01
Termination of O-glycan biosynthesis 10 8.69e-01 0.030100 9.33e-01
rRNA modification in the nucleus and cytosol 49 7.17e-01 -0.030000 8.20e-01
Ephrin signaling 12 8.59e-01 -0.029700 9.27e-01
Chondroitin sulfate/dermatan sulfate metabolism 27 7.90e-01 0.029700 8.71e-01
Pre-NOTCH Expression and Processing 46 7.29e-01 -0.029600 8.27e-01
Regulation of IFNG signaling 13 8.54e-01 0.029600 9.23e-01
Regulation of PTEN gene transcription 48 7.26e-01 -0.029200 8.25e-01
RAB geranylgeranylation 40 7.52e-01 0.028900 8.47e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 33 7.74e-01 0.028900 8.61e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 20 8.27e-01 -0.028300 9.00e-01
Pre-NOTCH Transcription and Translation 31 7.86e-01 -0.028200 8.70e-01
Downregulation of ERBB2:ERBB3 signaling 10 8.78e-01 0.028000 9.37e-01
Regulation of BACH1 activity 11 8.74e-01 -0.027700 9.34e-01
Protein methylation 14 8.66e-01 0.026000 9.31e-01
Synthesis of bile acids and bile salts 13 8.74e-01 0.025500 9.34e-01
Spry regulation of FGF signaling 15 8.65e-01 -0.025400 9.31e-01
Transmission across Chemical Synapses 101 6.69e-01 0.024700 7.81e-01
Phospholipid metabolism 133 6.25e-01 -0.024600 7.48e-01
Zinc transporters 12 8.84e-01 -0.024400 9.39e-01
RHOB GTPase cycle 44 7.93e-01 -0.022900 8.73e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 14 8.83e-01 0.022800 9.39e-01
Late endosomal microautophagy 23 8.51e-01 -0.022700 9.21e-01
Signaling by FGFR4 25 8.46e-01 -0.022400 9.18e-01
Integrin cell surface interactions 25 8.51e-01 0.021800 9.21e-01
Constitutive Signaling by Aberrant PI3K in Cancer 28 8.43e-01 0.021700 9.17e-01
Regulation of TP53 Activity through Methylation 17 8.78e-01 -0.021500 9.37e-01
ROS and RNS production in phagocytes 23 8.63e-01 -0.020800 9.30e-01
Negative regulation of the PI3K/AKT network 56 7.90e-01 -0.020600 8.71e-01
Inflammasomes 16 8.87e-01 -0.020400 9.41e-01
Apoptotic cleavage of cellular proteins 25 8.63e-01 -0.019900 9.30e-01
Prolonged ERK activation events 13 9.02e-01 0.019800 9.51e-01
Detoxification of Reactive Oxygen Species 23 8.70e-01 0.019600 9.33e-01
RHO GTPases Activate ROCKs 13 9.07e-01 -0.018700 9.52e-01
Metabolic disorders of biological oxidation enzymes 14 9.06e-01 -0.018300 9.52e-01
Calnexin/calreticulin cycle 23 8.80e-01 -0.018100 9.37e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 19 8.91e-01 -0.018100 9.44e-01
Phosphorylation of the APC/C 18 8.94e-01 -0.018100 9.45e-01
Carboxyterminal post-translational modifications of tubulin 24 8.79e-01 -0.018000 9.37e-01
Processing of SMDT1 13 9.11e-01 -0.017800 9.54e-01
NR1H2 and NR1H3-mediated signaling 27 8.73e-01 0.017800 9.34e-01
Negative regulation of MET activity 16 9.02e-01 0.017800 9.51e-01
Infection with Mycobacterium tuberculosis 22 8.86e-01 0.017600 9.41e-01
CD209 (DC-SIGN) signaling 15 9.07e-01 -0.017400 9.52e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 16 9.07e-01 -0.016800 9.52e-01
Synthesis of PIPs at the Golgi membrane 12 9.21e-01 -0.016500 9.58e-01
Leishmania infection 112 7.64e-01 -0.016400 8.56e-01
Regulation of RUNX1 Expression and Activity 17 9.07e-01 0.016300 9.52e-01
Cell-Cell communication 48 8.46e-01 0.016200 9.18e-01
FOXO-mediated transcription of cell cycle genes 13 9.20e-01 -0.016000 9.58e-01
Synthesis of PIPs at the early endosome membrane 12 9.25e-01 0.015800 9.59e-01
SLC-mediated transmembrane transport 105 7.87e-01 -0.015300 8.70e-01
Neurexins and neuroligins 21 9.04e-01 -0.015200 9.52e-01
Regulation of insulin secretion 40 8.68e-01 0.015200 9.33e-01
Myogenesis 13 9.25e-01 -0.015100 9.59e-01
Nuclear events stimulated by ALK signaling in cancer 14 9.28e-01 0.014000 9.61e-01
FLT3 Signaling 32 8.93e-01 -0.013700 9.44e-01
Synthesis of PIPs at the plasma membrane 36 8.88e-01 -0.013500 9.41e-01
The NLRP3 inflammasome 12 9.39e-01 0.012700 9.66e-01
Syndecan interactions 10 9.45e-01 -0.012500 9.69e-01
RUNX2 regulates osteoblast differentiation 13 9.38e-01 -0.012400 9.66e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 50 8.79e-01 -0.012400 9.37e-01
Interconversion of nucleotide di- and triphosphates 25 9.15e-01 -0.012300 9.55e-01
Ion channel transport 80 8.53e-01 -0.012000 9.23e-01
RND3 GTPase cycle 29 9.11e-01 -0.012000 9.54e-01
PI3K Cascade 19 9.30e-01 0.011600 9.62e-01
Sensory processing of sound 27 9.17e-01 -0.011500 9.55e-01
Sensory processing of sound by inner hair cells of the cochlea 27 9.17e-01 -0.011500 9.55e-01
Growth hormone receptor signaling 17 9.36e-01 0.011300 9.66e-01
NRAGE signals death through JNK 30 9.16e-01 0.011200 9.55e-01
Downregulation of ERBB2 signaling 17 9.37e-01 -0.011100 9.66e-01
Transport of bile salts and organic acids, metal ions and amine compounds 34 9.15e-01 0.010600 9.55e-01
Lysosome Vesicle Biogenesis 24 9.31e-01 -0.010200 9.62e-01
PI Metabolism 60 8.92e-01 -0.010100 9.44e-01
O-linked glycosylation of mucins 26 9.29e-01 0.010000 9.62e-01
Signaling by RAF1 mutants 25 9.36e-01 -0.009240 9.66e-01
Response of Mtb to phagocytosis 20 9.44e-01 -0.009050 9.68e-01
Signaling by high-kinase activity BRAF mutants 22 9.42e-01 -0.008940 9.67e-01
Uptake and actions of bacterial toxins 18 9.49e-01 0.008630 9.71e-01
Signaling by Insulin receptor 42 9.24e-01 0.008540 9.59e-01
Interleukin-2 family signaling 28 9.38e-01 0.008460 9.66e-01
Dopamine Neurotransmitter Release Cycle 12 9.60e-01 0.008440 9.78e-01
RUNX2 regulates bone development 18 9.52e-01 0.008260 9.73e-01
Signaling by FGFR1 28 9.41e-01 -0.008140 9.66e-01
Amino acid transport across the plasma membrane 16 9.59e-01 0.007420 9.78e-01
Protein-protein interactions at synapses 33 9.49e-01 0.006460 9.71e-01
mTORC1-mediated signalling 21 9.61e-01 0.006240 9.78e-01
Degradation of the extracellular matrix 35 9.55e-01 0.005530 9.75e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 9.69e-01 -0.005220 9.83e-01
Signaling by FGFR3 26 9.64e-01 -0.005160 9.81e-01
Amyloid fiber formation 27 9.67e-01 -0.004630 9.83e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 15 9.80e-01 -0.003710 9.90e-01
RHO GTPase cycle 294 9.15e-01 0.003630 9.55e-01
IRS-mediated signalling 21 9.78e-01 0.003410 9.89e-01
FCGR3A-mediated phagocytosis 42 9.71e-01 0.003240 9.83e-01
Leishmania phagocytosis 42 9.71e-01 0.003240 9.83e-01
Parasite infection 42 9.71e-01 0.003240 9.83e-01
Maturation of nucleoprotein 11 9.85e-01 -0.003210 9.91e-01
Oxidative Stress Induced Senescence 55 9.71e-01 0.002880 9.83e-01
ADORA2B mediated anti-inflammatory cytokines production 33 9.82e-01 -0.002300 9.91e-01
Sensory Perception 68 9.76e-01 0.002150 9.87e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 38 9.83e-01 0.001940 9.91e-01
TGF-beta receptor signaling activates SMADs 39 9.85e-01 0.001710 9.91e-01
E2F mediated regulation of DNA replication 19 9.91e-01 -0.001550 9.94e-01
RHOC GTPase cycle 49 9.87e-01 0.001360 9.91e-01
Interleukin-17 signaling 52 9.87e-01 -0.001340 9.91e-01
Neurotransmitter receptors and postsynaptic signal transmission 77 9.84e-01 0.001330 9.91e-01
Budding and maturation of HIV virion 24 9.92e-01 -0.001140 9.95e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 11 9.96e-01 0.000803 9.97e-01
TP53 Regulates Transcription of Cell Death Genes 31 9.95e-01 0.000608 9.97e-01
Transcriptional Regulation by MECP2 31 9.97e-01 0.000358 9.97e-01



Detailed Gene set reports



Signaling by FGFR2 IIIa TM

Signaling by FGFR2 IIIa TM
971
set Signaling by FGFR2 IIIa TM
setSize 15
pANOVA 9.84e-05
s.dist -0.581
p.adjustANOVA 0.00169



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11114.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
POLR2C -7787.0
POLR2H -7744.0
POLR2G -3915.0
POLR2K -2872.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11114.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
POLR2C -7787.0
POLR2H -7744.0
POLR2G -3915.0
POLR2K -2872.0



TNFs bind their physiological receptors

TNFs bind their physiological receptors
1066
set TNFs bind their physiological receptors
setSize 10
pANOVA 0.00935
s.dist 0.475
p.adjustANOVA 0.0366



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNFRSF25 566.0
EDARADD 0.5
TNFSF14 0.5
CD27 -1338.0
TNFRSF1B -1498.0
LTA -1742.0
TNFSF13 -1822.5
TNFSF9 -3475.0
TNFRSF1A -6875.0
TNFSF13B -7586.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNFRSF25 566.0
EDARADD 0.5
TNFSF14 0.5
CD27 -1338.0
TNFRSF1B -1498.0
LTA -1742.0
TNFSF13 -1822.5
TNFSF9 -3475.0
TNFRSF1A -6875.0
TNFSF13B -7586.0



Inhibition of DNA recombination at telomere

Inhibition of DNA recombination at telomere
448
set Inhibition of DNA recombination at telomere
setSize 18
pANOVA 0.000678
s.dist -0.463
p.adjustANOVA 0.00559



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
TERF2IP -10500.5
POLR2F -10467.5
POLR2L -10380.5
DAXX -10076.0
TINF2 -9186.0
POLR2E -8601.0
POLR2I -8371.5
POLR2C -7787.0
POLR2H -7744.0
ACD -6775.5
TERF2 -6009.0
H2AFX -4953.0
TERF1 -4423.0
POLR2G -3915.0
POLR2K -2872.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
TERF2IP -10500.5
POLR2F -10467.5
POLR2L -10380.5
DAXX -10076.0
TINF2 -9186.0
POLR2E -8601.0
POLR2I -8371.5
POLR2C -7787.0
POLR2H -7744.0
ACD -6775.5
TERF2 -6009.0
H2AFX -4953.0
TERF1 -4423.0
POLR2G -3915.0
POLR2K -2872.0



FGFR2 mutant receptor activation

FGFR2 mutant receptor activation
309
set FGFR2 mutant receptor activation
setSize 17
pANOVA 0.00117
s.dist -0.455
p.adjustANOVA 0.00775



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11114.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
POLR2C -7787.0
POLR2H -7744.0
FGF9 -4554.0
POLR2G -3915.0
POLR2K -2872.0
FGF8 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11114.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
POLR2C -7787.0
POLR2H -7744.0
FGF9 -4554.0
POLR2G -3915.0
POLR2K -2872.0
FGF8 0.5



TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
1072
set TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
setSize 12
pANOVA 0.0089
s.dist -0.436
p.adjustANOVA 0.0353



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDKN1B -10926.0
E2F7 -10184.0
CCNE1 -10174.0
CCNA2 -9888.0
TP53 -9885.5
E2F8 -9811.0
PCBP4 -9678.0
E2F1 -7525.0
CCNE2 -5648.0
CDK2 -5295.0
ARID3A -5076.0
CDKN1A 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDKN1B -10926.0
E2F7 -10184.0
CCNE1 -10174.0
CCNA2 -9888.0
TP53 -9885.5
E2F8 -9811.0
PCBP4 -9678.0
E2F1 -7525.0
CCNE2 -5648.0
CDK2 -5295.0
ARID3A -5076.0
CDKN1A 0.5



TNFR1-induced proapoptotic signaling

TNFR1-induced proapoptotic signaling
1064
set TNFR1-induced proapoptotic signaling
setSize 12
pANOVA 0.00903
s.dist -0.435
p.adjustANOVA 0.0356



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNFAIP3 -10705.0
USP4 -10459.0
CYLD -9698.0
FADD -9600.0
TRADD -9428.5
USP2 -7516.0
USP21 -7350.0
TRAF2 -7293.0
TNFRSF1A -6875.0
OTUD7B -6731.0
CASP8 -4236.0
TNF -4137.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNFAIP3 -10705.0
USP4 -10459.0
CYLD -9698.0
FADD -9600.0
TRADD -9428.5
USP2 -7516.0
USP21 -7350.0
TRAF2 -7293.0
TNFRSF1A -6875.0
OTUD7B -6731.0
CASP8 -4236.0
TNF -4137.0



mRNA Capping

mRNA Capping
1181
set mRNA Capping
setSize 26
pANOVA 0.000206
s.dist -0.421
p.adjustANOVA 0.00239



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11114.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
POLR2F -10467.5
RNMT -10466.0
POLR2L -10380.5
SUPT5H -10348.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
CCNH -7205.0
GTF2H5 -6121.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11114.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
POLR2F -10467.5
RNMT -10466.0
POLR2L -10380.5
SUPT5H -10348.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
CCNH -7205.0
GTF2H5 -6121.5
POLR2G -3915.0
CDK7 -3477.0
POLR2K -2872.0
MNAT1 -1528.0
ERCC3 -1496.0
RNGTT -771.0



Signaling by FGFR2 in disease

Signaling by FGFR2 in disease
972
set Signaling by FGFR2 in disease
setSize 24
pANOVA 0.000366
s.dist -0.42
p.adjustANOVA 0.00352



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11114.5
GRB2 -10839.0
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
PIK3R1 -9732.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
POLR2C -7787.0
POLR2H -7744.0
PIK3CA -6756.0
PLCG1 -6564.0
KRAS -5891.0
HRAS -5455.0
FRS2 -5433.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11114.5
GRB2 -10839.0
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
PIK3R1 -9732.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
POLR2C -7787.0
POLR2H -7744.0
PIK3CA -6756.0
PLCG1 -6564.0
KRAS -5891.0
HRAS -5455.0
FRS2 -5433.0
FGF9 -4554.0
POLR2G -3915.0
POLR2K -2872.0
FGF8 0.5



Competing endogenous RNAs (ceRNAs) regulate PTEN translation

Competing endogenous RNAs (ceRNAs) regulate PTEN translation
162
set Competing endogenous RNAs (ceRNAs) regulate PTEN translation
setSize 10
pANOVA 0.0214
s.dist 0.42
p.adjustANOVA 0.0726



Top enriched genes

Top 20 genes
GeneID Gene Rank
AGO3 0.5
AGO1 0.5
MIR19A 0.5
MIR17 -1762.0
TNRC6B -2401.0
MOV10 -2500.0
AGO2 -2845.0
CNOT6L -4728.0
TNRC6A -5956.0
VAPA -6852.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AGO3 0.5
AGO1 0.5
MIR19A 0.5
MIR17 -1762.0
TNRC6B -2401.0
MOV10 -2500.0
AGO2 -2845.0
CNOT6L -4728.0
TNRC6A -5956.0
VAPA -6852.0



Purine salvage

Purine salvage
745
set Purine salvage
setSize 11
pANOVA 0.0176
s.dist -0.413
p.adjustANOVA 0.0627



Top enriched genes

Top 20 genes
GeneID Gene Rank
GMPR2 -10971.5
ADK -10538.0
AMPD2 -10260.0
APRT -9472.0
ADAL -9312.5
DCK -7773.0
AMPD3 -6759.0
PNP -6639.0
DGUOK -5513.0
GMPR -5145.0
ADA -2358.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GMPR2 -10971.5
ADK -10538.0
AMPD2 -10260.0
APRT -9472.0
ADAL -9312.5
DCK -7773.0
AMPD3 -6759.0
PNP -6639.0
DGUOK -5513.0
GMPR -5145.0
ADA -2358.0



Abortive elongation of HIV-1 transcript in the absence of Tat

Abortive elongation of HIV-1 transcript in the absence of Tat
24
set Abortive elongation of HIV-1 transcript in the absence of Tat
setSize 22
pANOVA 0.000932
s.dist -0.408
p.adjustANOVA 0.00691



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11114.5
POLR2D -10830.0
SUPT4H1 -10827.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
SUPT5H -10348.0
CTDP1 -9760.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
POLR2C -7787.0
POLR2H -7744.0
POLR2G -3915.0
NELFA -3818.0
NELFB -3347.0
POLR2K -2872.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11114.5
POLR2D -10830.0
SUPT4H1 -10827.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
SUPT5H -10348.0
CTDP1 -9760.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
POLR2C -7787.0
POLR2H -7744.0
POLR2G -3915.0
NELFA -3818.0
NELFB -3347.0
POLR2K -2872.0
NELFCD 0.5
NELFE 0.5



SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
908
set SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize 10
pANOVA 0.0274
s.dist -0.403
p.adjustANOVA 0.0863



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11114.5
SNRPG -10153.0
LSM10 -9096.0
LSM11 -8890.0
NCBP2 -8252.0
ZNF473 -8201.5
SNRPD3 -8084.0
SLBP -7252.0
SNRPE -4548.0
SNRPB -829.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11114.5
SNRPG -10153.0
LSM10 -9096.0
LSM11 -8890.0
NCBP2 -8252.0
ZNF473 -8201.5
SNRPD3 -8084.0
SLBP -7252.0
SNRPE -4548.0
SNRPB -829.0



Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects

Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
21
set Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
setSize 16
pANOVA 0.00549
s.dist -0.401
p.adjustANOVA 0.0236



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDKN1B -10926.0
CCND1 -10727.0
CCND2 -10382.0
CCND3 -10179.0
CCNE1 -10174.0
RB1 -9349.0
CDK6 -9142.0
E2F3 -8327.0
E2F1 -7525.0
CDK4 -7376.0
E2F2 -6440.0
TFDP1 -6131.0
CCNE2 -5648.0
CDK2 -5295.0
TFDP2 -4443.0
CDKN1A 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDKN1B -10926.0
CCND1 -10727.0
CCND2 -10382.0
CCND3 -10179.0
CCNE1 -10174.0
RB1 -9349.0
CDK6 -9142.0
E2F3 -8327.0
E2F1 -7525.0
CDK4 -7376.0
E2F2 -6440.0
TFDP1 -6131.0
CCNE2 -5648.0
CDK2 -5295.0
TFDP2 -4443.0
CDKN1A 0.5



Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)

Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
214
set Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
setSize 16
pANOVA 0.00549
s.dist -0.401
p.adjustANOVA 0.0236



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDKN1B -10926.0
CCND1 -10727.0
CCND2 -10382.0
CCND3 -10179.0
CCNE1 -10174.0
RB1 -9349.0
CDK6 -9142.0
E2F3 -8327.0
E2F1 -7525.0
CDK4 -7376.0
E2F2 -6440.0
TFDP1 -6131.0
CCNE2 -5648.0
CDK2 -5295.0
TFDP2 -4443.0
CDKN1A 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDKN1B -10926.0
CCND1 -10727.0
CCND2 -10382.0
CCND3 -10179.0
CCNE1 -10174.0
RB1 -9349.0
CDK6 -9142.0
E2F3 -8327.0
E2F1 -7525.0
CDK4 -7376.0
E2F2 -6440.0
TFDP1 -6131.0
CCNE2 -5648.0
CDK2 -5295.0
TFDP2 -4443.0
CDKN1A 0.5



Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)
1042
set Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize 10
pANOVA 0.0288
s.dist 0.399
p.adjustANOVA 0.0896



Top enriched genes

Top 20 genes
GeneID Gene Rank
GGT1 591
DPEP2 -1249
LTA4H -1314
ALOX5AP -1446
LTC4S -2396
CYP4F22 -2423
PTGR1 -2444
MAPKAPK2 -3310
ALOX5 -5585
ABCC1 -8712

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GGT1 591
DPEP2 -1249
LTA4H -1314
ALOX5AP -1446
LTC4S -2396
CYP4F22 -2423
PTGR1 -2444
MAPKAPK2 -3310
ALOX5 -5585
ABCC1 -8712



Assembly of the ORC complex at the origin of replication

Assembly of the ORC complex at the origin of replication
66
set Assembly of the ORC complex at the origin of replication
setSize 10
pANOVA 0.0293
s.dist 0.398
p.adjustANOVA 0.0908



Top enriched genes

Top 20 genes
GeneID Gene Rank
ORC1 727.0
ORC3 0.5
KPNA6 -854.0
ORC5 -1355.0
ORC6 -1833.0
ORC4 -2085.5
ORC2 -3423.0
H2AFX -4953.0
KPNB1 -7061.0
KPNA1 -7530.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC1 727.0
ORC3 0.5
KPNA6 -854.0
ORC5 -1355.0
ORC6 -1833.0
ORC4 -2085.5
ORC2 -3423.0
H2AFX -4953.0
KPNB1 -7061.0
KPNA1 -7530.0



Endosomal/Vacuolar pathway

Endosomal/Vacuolar pathway
287
set Endosomal/Vacuolar pathway
setSize 10
pANOVA 0.0297
s.dist -0.397
p.adjustANOVA 0.0914



Top enriched genes

Top 20 genes
GeneID Gene Rank
HLA-E -11221
HLA-C -11127
HLA-B -10804
HLA-H -10398
HLA-F -9491
LNPEP -8485
HLA-A -6825
CTSL -4314
CTSV -2858
B2M -551

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HLA-E -11221
HLA-C -11127
HLA-B -10804
HLA-H -10398
HLA-F -9491
LNPEP -8485
HLA-A -6825
CTSL -4314
CTSV -2858
B2M -551



RNA Pol II CTD phosphorylation and interaction with CE

RNA Pol II CTD phosphorylation and interaction with CE
786
set RNA Pol II CTD phosphorylation and interaction with CE
setSize 24
pANOVA 0.000847
s.dist -0.394
p.adjustANOVA 0.00656



Top enriched genes

Top 20 genes
GeneID Gene Rank
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
POLR2F -10467.5
RNMT -10466.0
POLR2L -10380.5
SUPT5H -10348.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
CCNH -7205.0
GTF2H5 -6121.5
POLR2G -3915.0
CDK7 -3477.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
POLR2F -10467.5
RNMT -10466.0
POLR2L -10380.5
SUPT5H -10348.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
CCNH -7205.0
GTF2H5 -6121.5
POLR2G -3915.0
CDK7 -3477.0
POLR2K -2872.0
MNAT1 -1528.0
ERCC3 -1496.0
RNGTT -771.0



RNA Pol II CTD phosphorylation and interaction with CE during HIV infection

RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
787
set RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
setSize 24
pANOVA 0.000847
s.dist -0.394
p.adjustANOVA 0.00656



Top enriched genes

Top 20 genes
GeneID Gene Rank
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
POLR2F -10467.5
RNMT -10466.0
POLR2L -10380.5
SUPT5H -10348.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
CCNH -7205.0
GTF2H5 -6121.5
POLR2G -3915.0
CDK7 -3477.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
POLR2F -10467.5
RNMT -10466.0
POLR2L -10380.5
SUPT5H -10348.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
CCNH -7205.0
GTF2H5 -6121.5
POLR2G -3915.0
CDK7 -3477.0
POLR2K -2872.0
MNAT1 -1528.0
ERCC3 -1496.0
RNGTT -771.0



FGFR2 alternative splicing

FGFR2 alternative splicing
308
set FGFR2 alternative splicing
setSize 22
pANOVA 0.00157
s.dist -0.389
p.adjustANOVA 0.00921



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11114.5
HNRNPF -11102.0
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
POLR2C -7787.0
POLR2H -7744.0
TIA1 -7651.0
TIAL1 -6974.0
POLR2G -3915.0
ESRP2 -3327.0
POLR2K -2872.0
HNRNPH1 -2782.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11114.5
HNRNPF -11102.0
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
POLR2C -7787.0
POLR2H -7744.0
TIA1 -7651.0
TIAL1 -6974.0
POLR2G -3915.0
ESRP2 -3327.0
POLR2K -2872.0
HNRNPH1 -2782.0
PTBP1 -2566.0
HNRNPM -1277.0



alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
1178
set alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize 10
pANOVA 0.0393
s.dist -0.376
p.adjustANOVA 0.113



Top enriched genes

Top 20 genes
GeneID Gene Rank
ELOVL1 -10920.0
FADS2 -10853.0
FADS1 -10280.0
ACOX1 -8873.0
ACAA1 -8609.0
SCP2 -7055.0
ELOVL5 -6979.0
ACOT8 -5223.5
ACSL1 -3458.0
HSD17B4 -2577.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ELOVL1 -10920.0
FADS2 -10853.0
FADS1 -10280.0
ACOX1 -8873.0
ACAA1 -8609.0
SCP2 -7055.0
ELOVL5 -6979.0
ACOT8 -5223.5
ACSL1 -3458.0
HSD17B4 -2577.0



alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism
1179
set alpha-linolenic acid (ALA) metabolism
setSize 10
pANOVA 0.0393
s.dist -0.376
p.adjustANOVA 0.113



Top enriched genes

Top 20 genes
GeneID Gene Rank
ELOVL1 -10920.0
FADS2 -10853.0
FADS1 -10280.0
ACOX1 -8873.0
ACAA1 -8609.0
SCP2 -7055.0
ELOVL5 -6979.0
ACOT8 -5223.5
ACSL1 -3458.0
HSD17B4 -2577.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ELOVL1 -10920.0
FADS2 -10853.0
FADS1 -10280.0
ACOX1 -8873.0
ACAA1 -8609.0
SCP2 -7055.0
ELOVL5 -6979.0
ACOT8 -5223.5
ACSL1 -3458.0
HSD17B4 -2577.0



Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs
731
set Processing of Intronless Pre-mRNAs
setSize 15
pANOVA 0.0125
s.dist -0.373
p.adjustANOVA 0.0468



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11114.5
CPSF4 -10263.5
CLP1 -10254.0
SYMPK -10049.0
CPSF2 -10040.5
PAPOLA -9422.0
CPSF1 -8812.0
FIP1L1 -8322.0
NCBP2 -8252.0
CPSF3 -6846.5
CSTF1 -5237.5
WDR33 -5196.0
NUDT21 -4334.5
CPSF6 -2510.0
PABPN1 -1239.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11114.5
CPSF4 -10263.5
CLP1 -10254.0
SYMPK -10049.0
CPSF2 -10040.5
PAPOLA -9422.0
CPSF1 -8812.0
FIP1L1 -8322.0
NCBP2 -8252.0
CPSF3 -6846.5
CSTF1 -5237.5
WDR33 -5196.0
NUDT21 -4334.5
CPSF6 -2510.0
PABPN1 -1239.0



SUMOylation of immune response proteins

SUMOylation of immune response proteins
922
set SUMOylation of immune response proteins
setSize 10
pANOVA 0.0443
s.dist -0.367
p.adjustANOVA 0.126



Top enriched genes

Top 20 genes
GeneID Gene Rank
NFKB2 -10948
UBE2I -9641
NFKBIA -9113
PIAS4 -7982
RELA -7688
PIAS3 -7677
IKBKE -6700
SUMO1 -6129
TOPORS -5898
SUMO3 -2508

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NFKB2 -10948
UBE2I -9641
NFKBIA -9113
PIAS4 -7982
RELA -7688
PIAS3 -7677
IKBKE -6700
SUMO1 -6129
TOPORS -5898
SUMO3 -2508



Other semaphorin interactions

Other semaphorin interactions
664
set Other semaphorin interactions
setSize 10
pANOVA 0.0454
s.dist 0.365
p.adjustANOVA 0.128



Top enriched genes

Top 20 genes
GeneID Gene Rank
SEMA4D 620.0
TYROBP 0.5
SEMA4A 0.5
PTPRC 0.5
PLXNA2 -711.0
CD72 -878.0
PLXNC1 -4978.0
PLXND1 -6751.0
ITGA1 -7915.5
SEMA7A -9712.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SEMA4D 620.0
TYROBP 0.5
SEMA4A 0.5
PTPRC 0.5
PLXNA2 -711.0
CD72 -878.0
PLXNC1 -4978.0
PLXND1 -6751.0
ITGA1 -7915.5
SEMA7A -9712.0



Signaling by ERBB2 ECD mutants

Signaling by ERBB2 ECD mutants
960
set Signaling by ERBB2 ECD mutants
setSize 10
pANOVA 0.0465
s.dist -0.364
p.adjustANOVA 0.131



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 -10839.0
HSP90AA1 -10443.0
PIK3R1 -9732.0
CDC37 -9273.5
PIK3CA -6756.0
SHC1 -6692.5
PLCG1 -6564.0
KRAS -5891.0
HRAS -5455.0
ERBB2 -2414.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 -10839.0
HSP90AA1 -10443.0
PIK3R1 -9732.0
CDC37 -9273.5
PIK3CA -6756.0
SHC1 -6692.5
PLCG1 -6564.0
KRAS -5891.0
HRAS -5455.0
ERBB2 -2414.0



Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Antigen Presentation: Folding, assembly and peptide loading of class I MHC
51
set Antigen Presentation: Folding, assembly and peptide loading of class I MHC
setSize 26
pANOVA 0.00158
s.dist -0.358
p.adjustANOVA 0.00921



Top enriched genes

Top 20 genes
GeneID Gene Rank
HLA-E -11221.0
TAPBP -11220.0
TAP1 -11215.0
HLA-C -11127.0
SEC24A -10906.0
SEC23A -10888.0
HLA-B -10804.0
HLA-H -10398.0
PDIA3 -9865.5
SEC24B -9588.0
ERAP1 -9538.0
HLA-F -9491.0
CALR -9246.0
SEC13 -8862.0
SEC31A -8445.0
BECN1 -7977.0
SAR1B -7849.0
TAP2 -6868.0
HLA-A -6825.0
CANX -3277.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HLA-E -11221.0
TAPBP -11220.0
TAP1 -11215.0
HLA-C -11127.0
SEC24A -10906.0
SEC23A -10888.0
HLA-B -10804.0
HLA-H -10398.0
PDIA3 -9865.5
SEC24B -9588.0
ERAP1 -9538.0
HLA-F -9491.0
CALR -9246.0
SEC13 -8862.0
SEC31A -8445.0
BECN1 -7977.0
SAR1B -7849.0
TAP2 -6868.0
HLA-A -6825.0
CANX -3277.0
SEC24D -2308.0
PIK3R4 -1874.0
SEC24C -1281.0
B2M -551.0
ATG14 0.5
ERAP2 0.5



Disorders of Developmental Biology

Disorders of Developmental Biology
248
set Disorders of Developmental Biology
setSize 10
pANOVA 0.05
s.dist -0.358
p.adjustANOVA 0.135



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKACA -10561
HDAC3 -10075
SIN3A -9334
NCOR1 -9314
CALM1 -8409
HDAC1 -7321
CAMK4 -6998
TBL1XR1 -6891
GPS2 -3196
NCOR2 -1627

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKACA -10561
HDAC3 -10075
SIN3A -9334
NCOR1 -9314
CALM1 -8409
HDAC1 -7321
CAMK4 -6998
TBL1XR1 -6891
GPS2 -3196
NCOR2 -1627



Disorders of Nervous System Development

Disorders of Nervous System Development
249
set Disorders of Nervous System Development
setSize 10
pANOVA 0.05
s.dist -0.358
p.adjustANOVA 0.135



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKACA -10561
HDAC3 -10075
SIN3A -9334
NCOR1 -9314
CALM1 -8409
HDAC1 -7321
CAMK4 -6998
TBL1XR1 -6891
GPS2 -3196
NCOR2 -1627

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKACA -10561
HDAC3 -10075
SIN3A -9334
NCOR1 -9314
CALM1 -8409
HDAC1 -7321
CAMK4 -6998
TBL1XR1 -6891
GPS2 -3196
NCOR2 -1627



Loss of function of MECP2 in Rett syndrome

Loss of function of MECP2 in Rett syndrome
515
set Loss of function of MECP2 in Rett syndrome
setSize 10
pANOVA 0.05
s.dist -0.358
p.adjustANOVA 0.135



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKACA -10561
HDAC3 -10075
SIN3A -9334
NCOR1 -9314
CALM1 -8409
HDAC1 -7321
CAMK4 -6998
TBL1XR1 -6891
GPS2 -3196
NCOR2 -1627

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKACA -10561
HDAC3 -10075
SIN3A -9334
NCOR1 -9314
CALM1 -8409
HDAC1 -7321
CAMK4 -6998
TBL1XR1 -6891
GPS2 -3196
NCOR2 -1627



Pervasive developmental disorders

Pervasive developmental disorders
695
set Pervasive developmental disorders
setSize 10
pANOVA 0.05
s.dist -0.358
p.adjustANOVA 0.135



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKACA -10561
HDAC3 -10075
SIN3A -9334
NCOR1 -9314
CALM1 -8409
HDAC1 -7321
CAMK4 -6998
TBL1XR1 -6891
GPS2 -3196
NCOR2 -1627

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKACA -10561
HDAC3 -10075
SIN3A -9334
NCOR1 -9314
CALM1 -8409
HDAC1 -7321
CAMK4 -6998
TBL1XR1 -6891
GPS2 -3196
NCOR2 -1627



Degradation of cysteine and homocysteine

Degradation of cysteine and homocysteine
223
set Degradation of cysteine and homocysteine
setSize 10
pANOVA 0.0503
s.dist -0.357
p.adjustANOVA 0.136



Top enriched genes

Top 20 genes
GeneID Gene Rank
GOT2 -10070.0
SQRDL -9997.0
CSAD -9926.5
ADO -9825.0
TSTD1 -9043.0
ETHE1 -6588.0
CTH -5391.0
TXN2 -4750.0
MPST -4050.5
TST -4050.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GOT2 -10070.0
SQRDL -9997.0
CSAD -9926.5
ADO -9825.0
TSTD1 -9043.0
ETHE1 -6588.0
CTH -5391.0
TXN2 -4750.0
MPST -4050.5
TST -4050.5



HIV elongation arrest and recovery

HIV elongation arrest and recovery
411
set HIV elongation arrest and recovery
setSize 27
pANOVA 0.00133
s.dist -0.357
p.adjustANOVA 0.00838



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2D -10830.0
SUPT4H1 -10827.0
CCNK -10778.5
CDK9 -10699.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
SUPT5H -10348.0
CTDP1 -9760.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
CCNT1 -8065.0
POLR2C -7787.0
POLR2H -7744.0
SSRP1 -6661.0
TCEA1 -5199.0
SUPT16H -4348.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2D -10830.0
SUPT4H1 -10827.0
CCNK -10778.5
CDK9 -10699.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
SUPT5H -10348.0
CTDP1 -9760.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
CCNT1 -8065.0
POLR2C -7787.0
POLR2H -7744.0
SSRP1 -6661.0
TCEA1 -5199.0
SUPT16H -4348.0
POLR2G -3915.0
NELFA -3818.0
ELL -3699.0
NELFB -3347.0
POLR2K -2872.0
NELFCD 0.5
NELFE 0.5



Pausing and recovery of HIV elongation

Pausing and recovery of HIV elongation
688
set Pausing and recovery of HIV elongation
setSize 27
pANOVA 0.00133
s.dist -0.357
p.adjustANOVA 0.00838



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2D -10830.0
SUPT4H1 -10827.0
CCNK -10778.5
CDK9 -10699.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
SUPT5H -10348.0
CTDP1 -9760.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
CCNT1 -8065.0
POLR2C -7787.0
POLR2H -7744.0
SSRP1 -6661.0
TCEA1 -5199.0
SUPT16H -4348.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2D -10830.0
SUPT4H1 -10827.0
CCNK -10778.5
CDK9 -10699.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
SUPT5H -10348.0
CTDP1 -9760.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
CCNT1 -8065.0
POLR2C -7787.0
POLR2H -7744.0
SSRP1 -6661.0
TCEA1 -5199.0
SUPT16H -4348.0
POLR2G -3915.0
NELFA -3818.0
ELL -3699.0
NELFB -3347.0
POLR2K -2872.0
NELFCD 0.5
NELFE 0.5



HIV Transcription Initiation

HIV Transcription Initiation
410
set HIV Transcription Initiation
setSize 39
pANOVA 0.000126
s.dist -0.355
p.adjustANOVA 0.00175



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
TAF12 -7698.0
CCNH -7205.0
TAF5 -7185.0
TAF15 -6771.0
GTF2E2 -6696.0
GTF2A1 -6642.0
TAF2 -6349.0
GTF2H5 -6121.5
TAF4B -6038.0
GTF2A2 -5706.0
TAF7 -5597.0
POLR2G -3915.0
TAF13 -3572.0
CDK7 -3477.0
TAF4 -3206.0
POLR2K -2872.0
MNAT1 -1528.0
ERCC3 -1496.0
GTF2B -527.0



RNA Polymerase II HIV Promoter Escape

RNA Polymerase II HIV Promoter Escape
793
set RNA Polymerase II HIV Promoter Escape
setSize 39
pANOVA 0.000126
s.dist -0.355
p.adjustANOVA 0.00175



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
TAF12 -7698.0
CCNH -7205.0
TAF5 -7185.0
TAF15 -6771.0
GTF2E2 -6696.0
GTF2A1 -6642.0
TAF2 -6349.0
GTF2H5 -6121.5
TAF4B -6038.0
GTF2A2 -5706.0
TAF7 -5597.0
POLR2G -3915.0
TAF13 -3572.0
CDK7 -3477.0
TAF4 -3206.0
POLR2K -2872.0
MNAT1 -1528.0
ERCC3 -1496.0
GTF2B -527.0



RNA Polymerase II Promoter Escape

RNA Polymerase II Promoter Escape
795
set RNA Polymerase II Promoter Escape
setSize 39
pANOVA 0.000126
s.dist -0.355
p.adjustANOVA 0.00175



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
TAF12 -7698.0
CCNH -7205.0
TAF5 -7185.0
TAF15 -6771.0
GTF2E2 -6696.0
GTF2A1 -6642.0
TAF2 -6349.0
GTF2H5 -6121.5
TAF4B -6038.0
GTF2A2 -5706.0
TAF7 -5597.0
POLR2G -3915.0
TAF13 -3572.0
CDK7 -3477.0
TAF4 -3206.0
POLR2K -2872.0
MNAT1 -1528.0
ERCC3 -1496.0
GTF2B -527.0



RNA Polymerase II Transcription Initiation

RNA Polymerase II Transcription Initiation
798
set RNA Polymerase II Transcription Initiation
setSize 39
pANOVA 0.000126
s.dist -0.355
p.adjustANOVA 0.00175



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
TAF12 -7698.0
CCNH -7205.0
TAF5 -7185.0
TAF15 -6771.0
GTF2E2 -6696.0
GTF2A1 -6642.0
TAF2 -6349.0
GTF2H5 -6121.5
TAF4B -6038.0
GTF2A2 -5706.0
TAF7 -5597.0
POLR2G -3915.0
TAF13 -3572.0
CDK7 -3477.0
TAF4 -3206.0
POLR2K -2872.0
MNAT1 -1528.0
ERCC3 -1496.0
GTF2B -527.0



RNA Polymerase II Transcription Initiation And Promoter Clearance

RNA Polymerase II Transcription Initiation And Promoter Clearance
799
set RNA Polymerase II Transcription Initiation And Promoter Clearance
setSize 39
pANOVA 0.000126
s.dist -0.355
p.adjustANOVA 0.00175



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
TAF12 -7698.0
CCNH -7205.0
TAF5 -7185.0
TAF15 -6771.0
GTF2E2 -6696.0
GTF2A1 -6642.0
TAF2 -6349.0
GTF2H5 -6121.5
TAF4B -6038.0
GTF2A2 -5706.0
TAF7 -5597.0
POLR2G -3915.0
TAF13 -3572.0
CDK7 -3477.0
TAF4 -3206.0
POLR2K -2872.0
MNAT1 -1528.0
ERCC3 -1496.0
GTF2B -527.0



RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
800
set RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
setSize 39
pANOVA 0.000126
s.dist -0.355
p.adjustANOVA 0.00175



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11152.5
GTF2H3 -10911.5
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
TAF6 -10475.5
POLR2F -10467.5
TBP -10407.5
TAF11 -10399.5
POLR2L -10380.5
TAF10 -9445.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
TAF3 -8320.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
TAF12 -7698.0
CCNH -7205.0
TAF5 -7185.0
TAF15 -6771.0
GTF2E2 -6696.0
GTF2A1 -6642.0
TAF2 -6349.0
GTF2H5 -6121.5
TAF4B -6038.0
GTF2A2 -5706.0
TAF7 -5597.0
POLR2G -3915.0
TAF13 -3572.0
CDK7 -3477.0
TAF4 -3206.0
POLR2K -2872.0
MNAT1 -1528.0
ERCC3 -1496.0
GTF2B -527.0



Processing of Capped Intronless Pre-mRNA

Processing of Capped Intronless Pre-mRNA
729
set Processing of Capped Intronless Pre-mRNA
setSize 23
pANOVA 0.00331
s.dist -0.354
p.adjustANOVA 0.0165



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11114.5
CPSF4 -10263.5
CLP1 -10254.0
SNRPG -10153.0
SYMPK -10049.0
CPSF2 -10040.5
PAPOLA -9422.0
LSM10 -9096.0
LSM11 -8890.0
CPSF1 -8812.0
FIP1L1 -8322.0
NCBP2 -8252.0
ZNF473 -8201.5
SNRPD3 -8084.0
SLBP -7252.0
CPSF3 -6846.5
CSTF1 -5237.5
WDR33 -5196.0
SNRPE -4548.0
NUDT21 -4334.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11114.5
CPSF4 -10263.5
CLP1 -10254.0
SNRPG -10153.0
SYMPK -10049.0
CPSF2 -10040.5
PAPOLA -9422.0
LSM10 -9096.0
LSM11 -8890.0
CPSF1 -8812.0
FIP1L1 -8322.0
NCBP2 -8252.0
ZNF473 -8201.5
SNRPD3 -8084.0
SLBP -7252.0
CPSF3 -6846.5
CSTF1 -5237.5
WDR33 -5196.0
SNRPE -4548.0
NUDT21 -4334.5
CPSF6 -2510.0
PABPN1 -1239.0
SNRPB -829.0



Purine ribonucleoside monophosphate biosynthesis

Purine ribonucleoside monophosphate biosynthesis
744
set Purine ribonucleoside monophosphate biosynthesis
setSize 10
pANOVA 0.0539
s.dist -0.352
p.adjustANOVA 0.142



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATIC -10117.0
GMPS -8921.0
IMPDH1 -8633.0
ADSL -8486.0
ADSS -8008.0
IMPDH2 -6946.0
PFAS -6504.0
PAICS -5498.5
PPAT -5498.5
ADSSL1 -4759.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATIC -10117.0
GMPS -8921.0
IMPDH1 -8633.0
ADSL -8486.0
ADSS -8008.0
IMPDH2 -6946.0
PFAS -6504.0
PAICS -5498.5
PPAT -5498.5
ADSSL1 -4759.0



PIWI-interacting RNA (piRNA) biogenesis

PIWI-interacting RNA (piRNA) biogenesis
677
set PIWI-interacting RNA (piRNA) biogenesis
setSize 16
pANOVA 0.015
s.dist -0.351
p.adjustANOVA 0.0544



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
POLR2F -10467.5
HSP90AA1 -10443.0
POLR2L -10380.5
POLR2E -8601.0
POLR2I -8371.5
POLR2C -7787.0
POLR2H -7744.0
HENMT1 -7103.0
TDRKH -4349.0
POLR2G -3915.0
POLR2K -2872.0
MYBL1 -2799.0
PLD6 -554.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2D -10830.0
POLR2A -10548.0
POLR2B -10534.0
POLR2F -10467.5
HSP90AA1 -10443.0
POLR2L -10380.5
POLR2E -8601.0
POLR2I -8371.5
POLR2C -7787.0
POLR2H -7744.0
HENMT1 -7103.0
TDRKH -4349.0
POLR2G -3915.0
POLR2K -2872.0
MYBL1 -2799.0
PLD6 -554.0



Cross-presentation of soluble exogenous antigens (endosomes)

Cross-presentation of soluble exogenous antigens (endosomes)
176
set Cross-presentation of soluble exogenous antigens (endosomes)
setSize 38
pANOVA 0.00018
s.dist -0.351
p.adjustANOVA 0.00223



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -11223.0
PSMB9 -11203.0
PSMB3 -11086.0
PSME1 -10729.0
PSMC5 -10693.5
PSMA2 -10497.5
PSMB1 -10407.5
PSMD11 -10335.0
PSMB6 -10197.0
PSME2 -10020.5
PSMD4 -9966.0
PSMA7 -9928.0
PSMD3 -9715.0
PSMD8 -9686.0
PSMC3 -9590.0
PSMA5 -9370.0
PSMB5 -9224.0
PSME3 -8631.0
PSMD1 -8165.0
PSMC1 -8119.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -11223.0
PSMB9 -11203.0
PSMB3 -11086.0
PSME1 -10729.0
PSMC5 -10693.5
PSMA2 -10497.5
PSMB1 -10407.5
PSMD11 -10335.0
PSMB6 -10197.0
PSME2 -10020.5
PSMD4 -9966.0
PSMA7 -9928.0
PSMD3 -9715.0
PSMD8 -9686.0
PSMC3 -9590.0
PSMA5 -9370.0
PSMB5 -9224.0
PSME3 -8631.0
PSMD1 -8165.0
PSMC1 -8119.0
PSMD14 -7970.0
PSMA1 -7634.0
PSMD9 -7543.0
MRC2 -7471.0
PSMD13 -7448.5
PSMB10 -6395.0
PSMA6 -6270.0
PSMA3 -5259.0
PSMD6 -4860.0
PSMD12 -4833.0
PSMD2 -4667.0
PSMD7 -4232.0
PSME4 -3622.0
PSMC4 -1218.0
PSMC6 -827.0
PSMF1 0.5
PSMB2 0.5
PSMB7 599.0



Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
1154
set Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
setSize 44
pANOVA 5.62e-05
s.dist -0.351
p.adjustANOVA 0.00111



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -11223.0
PSMB9 -11203.0
PSMB3 -11086.0
PSME1 -10729.0
PSMC5 -10693.5
PSMA2 -10497.5
PSMB1 -10407.5
PSMD11 -10335.0
PSMB6 -10197.0
PSME2 -10020.5
PSMD4 -9966.0
PSMA7 -9928.0
CHEK2 -9804.5
PSMD3 -9715.0
PSMD8 -9686.0
CHEK1 -9651.0
PSMC3 -9590.0
PSMA5 -9370.0
PSMB5 -9224.0
CDC25A -9120.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -11223.0
PSMB9 -11203.0
PSMB3 -11086.0
PSME1 -10729.0
PSMC5 -10693.5
PSMA2 -10497.5
PSMB1 -10407.5
PSMD11 -10335.0
PSMB6 -10197.0
PSME2 -10020.5
PSMD4 -9966.0
PSMA7 -9928.0
CHEK2 -9804.5
PSMD3 -9715.0
PSMD8 -9686.0
CHEK1 -9651.0
PSMC3 -9590.0
PSMA5 -9370.0
PSMB5 -9224.0
CDC25A -9120.0
PSME3 -8631.0
PSMD1 -8165.0
PSMC1 -8119.0
UBA52 -8098.0
PSMD14 -7970.0
PSMA1 -7634.0
PSMD9 -7543.0
PSMD13 -7448.5
PSMB10 -6395.0
PSMA6 -6270.0
UBB -5720.0
PSMA3 -5259.0
RPS27A -4937.0
PSMD6 -4860.0
PSMD12 -4833.0
PSMD2 -4667.0
PSMD7 -4232.0
UBC -4015.0
PSME4 -3622.0
PSMC4 -1218.0
PSMC6 -827.0
PSMF1 0.5
PSMB2 0.5
PSMB7 599.0



p53-Independent DNA Damage Response

p53-Independent DNA Damage Response
1190
set p53-Independent DNA Damage Response
setSize 44
pANOVA 5.62e-05
s.dist -0.351
p.adjustANOVA 0.00111



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -11223.0
PSMB9 -11203.0
PSMB3 -11086.0
PSME1 -10729.0
PSMC5 -10693.5
PSMA2 -10497.5
PSMB1 -10407.5
PSMD11 -10335.0
PSMB6 -10197.0
PSME2 -10020.5
PSMD4 -9966.0
PSMA7 -9928.0
CHEK2 -9804.5
PSMD3 -9715.0
PSMD8 -9686.0
CHEK1 -9651.0
PSMC3 -9590.0
PSMA5 -9370.0
PSMB5 -9224.0
CDC25A -9120.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -11223.0
PSMB9 -11203.0
PSMB3 -11086.0
PSME1 -10729.0
PSMC5 -10693.5
PSMA2 -10497.5
PSMB1 -10407.5
PSMD11 -10335.0
PSMB6 -10197.0
PSME2 -10020.5
PSMD4 -9966.0
PSMA7 -9928.0
CHEK2 -9804.5
PSMD3 -9715.0
PSMD8 -9686.0
CHEK1 -9651.0
PSMC3 -9590.0
PSMA5 -9370.0
PSMB5 -9224.0
CDC25A -9120.0
PSME3 -8631.0
PSMD1 -8165.0
PSMC1 -8119.0
UBA52 -8098.0
PSMD14 -7970.0
PSMA1 -7634.0
PSMD9 -7543.0
PSMD13 -7448.5
PSMB10 -6395.0
PSMA6 -6270.0
UBB -5720.0
PSMA3 -5259.0
RPS27A -4937.0
PSMD6 -4860.0
PSMD12 -4833.0
PSMD2 -4667.0
PSMD7 -4232.0
UBC -4015.0
PSME4 -3622.0
PSMC4 -1218.0
PSMC6 -827.0
PSMF1 0.5
PSMB2 0.5
PSMB7 599.0



p53-Independent G1/S DNA damage checkpoint

p53-Independent G1/S DNA damage checkpoint
1191
set p53-Independent G1/S DNA damage checkpoint
setSize 44
pANOVA 5.62e-05
s.dist -0.351
p.adjustANOVA 0.00111



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -11223.0
PSMB9 -11203.0
PSMB3 -11086.0
PSME1 -10729.0
PSMC5 -10693.5
PSMA2 -10497.5
PSMB1 -10407.5
PSMD11 -10335.0
PSMB6 -10197.0
PSME2 -10020.5
PSMD4 -9966.0
PSMA7 -9928.0
CHEK2 -9804.5
PSMD3 -9715.0
PSMD8 -9686.0
CHEK1 -9651.0
PSMC3 -9590.0
PSMA5 -9370.0
PSMB5 -9224.0
CDC25A -9120.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -11223.0
PSMB9 -11203.0
PSMB3 -11086.0
PSME1 -10729.0
PSMC5 -10693.5
PSMA2 -10497.5
PSMB1 -10407.5
PSMD11 -10335.0
PSMB6 -10197.0
PSME2 -10020.5
PSMD4 -9966.0
PSMA7 -9928.0
CHEK2 -9804.5
PSMD3 -9715.0
PSMD8 -9686.0
CHEK1 -9651.0
PSMC3 -9590.0
PSMA5 -9370.0
PSMB5 -9224.0
CDC25A -9120.0
PSME3 -8631.0
PSMD1 -8165.0
PSMC1 -8119.0
UBA52 -8098.0
PSMD14 -7970.0
PSMA1 -7634.0
PSMD9 -7543.0
PSMD13 -7448.5
PSMB10 -6395.0
PSMA6 -6270.0
UBB -5720.0
PSMA3 -5259.0
RPS27A -4937.0
PSMD6 -4860.0
PSMD12 -4833.0
PSMD2 -4667.0
PSMD7 -4232.0
UBC -4015.0
PSME4 -3622.0
PSMC4 -1218.0
PSMC6 -827.0
PSMF1 0.5
PSMB2 0.5
PSMB7 599.0



Viral Messenger RNA Synthesis

Viral Messenger RNA Synthesis
1166
set Viral Messenger RNA Synthesis
setSize 41
pANOVA 0.000108
s.dist -0.35
p.adjustANOVA 0.00175



Top enriched genes

Top 20 genes
GeneID Gene Rank
NUP153 -10890.0
POLR2D -10830.0
NUP37 -10665.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
NUP93 -10171.0
NUP155 -9979.0
NUP62 -9969.5
NUP160 -9771.0
NUP188 -9757.5
NUP88 -9734.5
NUP50 -9654.0
SEC13 -8862.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NUP85 -8226.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NUP153 -10890.0
POLR2D -10830.0
NUP37 -10665.0
POLR2A -10548.0
POLR2B -10534.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
NUP93 -10171.0
NUP155 -9979.0
NUP62 -9969.5
NUP160 -9771.0
NUP188 -9757.5
NUP88 -9734.5
NUP50 -9654.0
SEC13 -8862.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NUP85 -8226.0
POM121C -8104.0
POLR2C -7787.0
POLR2H -7744.0
NUP98 -7707.0
RANBP2 -6481.0
NUP214 -6458.0
NUP210 -6452.0
NUP133 -6383.0
RAE1 -5815.0
POM121 -5784.0
TPR -5774.0
NUP43 -5450.0
NUP54 -4573.0
POLR2G -3915.0
AAAS -3203.0
POLR2K -2872.0
SEH1L -2692.0
NUP107 -2551.0
NUP205 -2499.0
NUP35 -1130.0
NDC1 0.5



Striated Muscle Contraction

Striated Muscle Contraction
1033
set Striated Muscle Contraction
setSize 10
pANOVA 0.0569
s.dist -0.348
p.adjustANOVA 0.147



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACTN3 -10907.0
TMOD2 -10761.0
TPM3 -10131.0
TPM4 -8970.0
TMOD3 -8081.0
TNNC1 -6399.5
TPM1 -5932.0
TPM2 -5694.0
MYBPC2 -3652.0
VIM -2579.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACTN3 -10907.0
TMOD2 -10761.0
TPM3 -10131.0
TPM4 -8970.0
TMOD3 -8081.0
TNNC1 -6399.5
TPM1 -5932.0
TPM2 -5694.0
MYBPC2 -3652.0
VIM -2579.0



Formation of the Early Elongation Complex

Formation of the Early Elongation Complex
328
set Formation of the Early Elongation Complex
setSize 30
pANOVA 0.00126
s.dist -0.34
p.adjustANOVA 0.00815



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11114.5
GTF2H3 -10911.5
POLR2D -10830.0
SUPT4H1 -10827.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
SUPT5H -10348.0
CTDP1 -9760.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
CCNH -7205.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11114.5
GTF2H3 -10911.5
POLR2D -10830.0
SUPT4H1 -10827.0
POLR2A -10548.0
POLR2B -10534.0
GTF2H4 -10510.0
GTF2F2 -10486.0
POLR2F -10467.5
POLR2L -10380.5
SUPT5H -10348.0
CTDP1 -9760.0
GTF2F1 -8706.0
POLR2E -8601.0
POLR2I -8371.5
NCBP2 -8252.0
ERCC2 -7919.0
POLR2C -7787.0
POLR2H -7744.0
CCNH -7205.0
GTF2H5 -6121.5
POLR2G -3915.0
NELFA -3818.0
CDK7 -3477.0
NELFB -3347.0
POLR2K -2872.0
MNAT1 -1528.0
ERCC3 -1496.0
NELFCD 0.5
NELFE 0.5



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report