Mitch Report

date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##           metric
## PSMB8  -15.09965
## TAPBP  -14.48290
## CSNK2B -18.35266
## TAP1   -13.58930
## TRIM27 -17.73811
## BAT4   -18.19374

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2546
num_genes_in_profile	12012
duplicated_genes_present	0
num_profile_genes_in_sets	5835
num_profile_genes_not_in_sets	6177

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1344
num_genesets_included	1202

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Signaling by FGFR2 IIIa TM	15	9.84e-05	-0.581	0.00169
TNFs bind their physiological receptors	10	9.35e-03	0.475	0.03660
Inhibition of DNA recombination at telomere	18	6.78e-04	-0.463	0.00559
FGFR2 mutant receptor activation	17	1.17e-03	-0.455	0.00775
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	12	8.90e-03	-0.436	0.03530
TNFR1-induced proapoptotic signaling	12	9.03e-03	-0.435	0.03560
mRNA Capping	26	2.06e-04	-0.421	0.00239
Signaling by FGFR2 in disease	24	3.66e-04	-0.420	0.00352
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	2.14e-02	0.420	0.07260
Purine salvage	11	1.76e-02	-0.413	0.06270
Abortive elongation of HIV-1 transcript in the absence of Tat	22	9.32e-04	-0.408	0.00691
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	10	2.74e-02	-0.403	0.08630
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	5.49e-03	-0.401	0.02360
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	5.49e-03	-0.401	0.02360
Synthesis of Leukotrienes (LT) and Eoxins (EX)	10	2.88e-02	0.399	0.08960
Assembly of the ORC complex at the origin of replication	10	2.93e-02	0.398	0.09080
Endosomal/Vacuolar pathway	10	2.97e-02	-0.397	0.09140
RNA Pol II CTD phosphorylation and interaction with CE	24	8.47e-04	-0.394	0.00656
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	24	8.47e-04	-0.394	0.00656
FGFR2 alternative splicing	22	1.57e-03	-0.389	0.00921
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	3.93e-02	-0.376	0.11300
alpha-linolenic acid (ALA) metabolism	10	3.93e-02	-0.376	0.11300
Processing of Intronless Pre-mRNAs	15	1.25e-02	-0.373	0.04680
SUMOylation of immune response proteins	10	4.43e-02	-0.367	0.12600
Other semaphorin interactions	10	4.54e-02	0.365	0.12800
Signaling by ERBB2 ECD mutants	10	4.65e-02	-0.364	0.13100
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	26	1.58e-03	-0.358	0.00921
Disorders of Developmental Biology	10	5.00e-02	-0.358	0.13500
Disorders of Nervous System Development	10	5.00e-02	-0.358	0.13500
Loss of function of MECP2 in Rett syndrome	10	5.00e-02	-0.358	0.13500
Pervasive developmental disorders	10	5.00e-02	-0.358	0.13500
Degradation of cysteine and homocysteine	10	5.03e-02	-0.357	0.13600
HIV elongation arrest and recovery	27	1.33e-03	-0.357	0.00838
Pausing and recovery of HIV elongation	27	1.33e-03	-0.357	0.00838
HIV Transcription Initiation	39	1.26e-04	-0.355	0.00175
RNA Polymerase II HIV Promoter Escape	39	1.26e-04	-0.355	0.00175
RNA Polymerase II Promoter Escape	39	1.26e-04	-0.355	0.00175
RNA Polymerase II Transcription Initiation	39	1.26e-04	-0.355	0.00175
RNA Polymerase II Transcription Initiation And Promoter Clearance	39	1.26e-04	-0.355	0.00175
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	39	1.26e-04	-0.355	0.00175
Processing of Capped Intronless Pre-mRNA	23	3.31e-03	-0.354	0.01650
Purine ribonucleoside monophosphate biosynthesis	10	5.39e-02	-0.352	0.14200
PIWI-interacting RNA (piRNA) biogenesis	16	1.50e-02	-0.351	0.05440
Cross-presentation of soluble exogenous antigens (endosomes)	38	1.80e-04	-0.351	0.00223
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	44	5.62e-05	-0.351	0.00111
p53-Independent DNA Damage Response	44	5.62e-05	-0.351	0.00111
p53-Independent G1/S DNA damage checkpoint	44	5.62e-05	-0.351	0.00111
Viral Messenger RNA Synthesis	41	1.08e-04	-0.350	0.00175
Striated Muscle Contraction	10	5.69e-02	-0.348	0.14700
Formation of the Early Elongation Complex	30	1.26e-03	-0.340	0.00815

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Signaling by FGFR2 IIIa TM	15	9.84e-05	-0.581000	1.69e-03
TNFs bind their physiological receptors	10	9.35e-03	0.475000	3.66e-02
Inhibition of DNA recombination at telomere	18	6.78e-04	-0.463000	5.59e-03
FGFR2 mutant receptor activation	17	1.17e-03	-0.455000	7.75e-03
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	12	8.90e-03	-0.436000	3.53e-02
TNFR1-induced proapoptotic signaling	12	9.03e-03	-0.435000	3.56e-02
mRNA Capping	26	2.06e-04	-0.421000	2.39e-03
Signaling by FGFR2 in disease	24	3.66e-04	-0.420000	3.52e-03
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	2.14e-02	0.420000	7.26e-02
Purine salvage	11	1.76e-02	-0.413000	6.27e-02
Abortive elongation of HIV-1 transcript in the absence of Tat	22	9.32e-04	-0.408000	6.91e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	10	2.74e-02	-0.403000	8.63e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	5.49e-03	-0.401000	2.36e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	5.49e-03	-0.401000	2.36e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX)	10	2.88e-02	0.399000	8.96e-02
Assembly of the ORC complex at the origin of replication	10	2.93e-02	0.398000	9.08e-02
Endosomal/Vacuolar pathway	10	2.97e-02	-0.397000	9.14e-02
RNA Pol II CTD phosphorylation and interaction with CE	24	8.47e-04	-0.394000	6.56e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	24	8.47e-04	-0.394000	6.56e-03
FGFR2 alternative splicing	22	1.57e-03	-0.389000	9.21e-03
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	3.93e-02	-0.376000	1.13e-01
alpha-linolenic acid (ALA) metabolism	10	3.93e-02	-0.376000	1.13e-01
Processing of Intronless Pre-mRNAs	15	1.25e-02	-0.373000	4.68e-02
SUMOylation of immune response proteins	10	4.43e-02	-0.367000	1.26e-01
Other semaphorin interactions	10	4.54e-02	0.365000	1.28e-01
Signaling by ERBB2 ECD mutants	10	4.65e-02	-0.364000	1.31e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	26	1.58e-03	-0.358000	9.21e-03
Disorders of Developmental Biology	10	5.00e-02	-0.358000	1.35e-01
Disorders of Nervous System Development	10	5.00e-02	-0.358000	1.35e-01
Loss of function of MECP2 in Rett syndrome	10	5.00e-02	-0.358000	1.35e-01
Pervasive developmental disorders	10	5.00e-02	-0.358000	1.35e-01
Degradation of cysteine and homocysteine	10	5.03e-02	-0.357000	1.36e-01
HIV elongation arrest and recovery	27	1.33e-03	-0.357000	8.38e-03
Pausing and recovery of HIV elongation	27	1.33e-03	-0.357000	8.38e-03
HIV Transcription Initiation	39	1.26e-04	-0.355000	1.75e-03
RNA Polymerase II HIV Promoter Escape	39	1.26e-04	-0.355000	1.75e-03
RNA Polymerase II Promoter Escape	39	1.26e-04	-0.355000	1.75e-03
RNA Polymerase II Transcription Initiation	39	1.26e-04	-0.355000	1.75e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance	39	1.26e-04	-0.355000	1.75e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	39	1.26e-04	-0.355000	1.75e-03
Processing of Capped Intronless Pre-mRNA	23	3.31e-03	-0.354000	1.65e-02
Purine ribonucleoside monophosphate biosynthesis	10	5.39e-02	-0.352000	1.42e-01
PIWI-interacting RNA (piRNA) biogenesis	16	1.50e-02	-0.351000	5.44e-02
Cross-presentation of soluble exogenous antigens (endosomes)	38	1.80e-04	-0.351000	2.23e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	44	5.62e-05	-0.351000	1.11e-03
p53-Independent DNA Damage Response	44	5.62e-05	-0.351000	1.11e-03
p53-Independent G1/S DNA damage checkpoint	44	5.62e-05	-0.351000	1.11e-03
Viral Messenger RNA Synthesis	41	1.08e-04	-0.350000	1.75e-03
Striated Muscle Contraction	10	5.69e-02	-0.348000	1.47e-01
Formation of the Early Elongation Complex	30	1.26e-03	-0.340000	8.15e-03
Formation of the HIV-1 Early Elongation Complex	30	1.26e-03	-0.340000	8.15e-03
Gluconeogenesis	24	3.97e-03	-0.340000	1.83e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	3.53e-02	-0.337000	1.04e-01
Defects in vitamin and cofactor metabolism	16	1.97e-02	-0.337000	6.78e-02
Binding and Uptake of Ligands by Scavenger Receptors	10	6.54e-02	-0.336000	1.62e-01
Constitutive Signaling by EGFRvIII	10	6.58e-02	-0.336000	1.62e-01
Signaling by EGFRvIII in Cancer	10	6.58e-02	-0.336000	1.62e-01
Degradation of GLI2 by the proteasome	50	4.16e-05	-0.335000	9.13e-04
GLI3 is processed to GLI3R by the proteasome	50	4.16e-05	-0.335000	9.13e-04
Pausing and recovery of Tat-mediated HIV elongation	26	3.12e-03	-0.335000	1.56e-02
Tat-mediated HIV elongation arrest and recovery	26	3.12e-03	-0.335000	1.56e-02
Formation of HIV elongation complex in the absence of HIV Tat	37	4.38e-04	-0.334000	4.01e-03
Association of TriC/CCT with target proteins during biosynthesis	29	1.87e-03	-0.334000	1.06e-02
Ubiquitin-dependent degradation of Cyclin D	44	1.30e-04	-0.334000	1.75e-03
TRAF6 mediated IRF7 activation	16	2.10e-02	-0.333000	7.13e-02
Nucleotide salvage	18	1.45e-02	-0.333000	5.31e-02
Sulfur amino acid metabolism	17	1.76e-02	-0.333000	6.27e-02
Transport of Mature mRNAs Derived from Intronless Transcripts	41	2.37e-04	-0.332000	2.64e-03
Metabolism of folate and pterines	11	5.68e-02	-0.332000	1.47e-01
Transport of Mature mRNA Derived from an Intronless Transcript	40	2.85e-04	-0.332000	3.03e-03
TRAF6 mediated NF-kB activation	19	1.28e-02	-0.330000	4.76e-02
Signaling by PDGFR in disease	15	2.79e-02	-0.328000	8.74e-02
Synthesis of glycosylphosphatidylinositol (GPI)	14	3.42e-02	-0.327000	1.01e-01
Regulation of PTEN stability and activity	56	2.73e-05	-0.324000	7.14e-04
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	46	1.63e-04	-0.321000	2.08e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA	46	1.71e-04	-0.320000	2.17e-03
Rev-mediated nuclear export of HIV RNA	33	1.51e-03	-0.319000	8.96e-03
Interactions of Rev with host cellular proteins	34	1.29e-03	-0.319000	8.28e-03
Processive synthesis on the lagging strand	13	4.65e-02	-0.319000	1.31e-01
Keratan sulfate/keratin metabolism	18	1.93e-02	-0.318000	6.71e-02
Generation of second messenger molecules	15	3.29e-02	0.318000	9.74e-02
SCF(Skp2)-mediated degradation of p27/p21	52	7.35e-05	-0.318000	1.40e-03
Formation of HIV-1 elongation complex containing HIV-1 Tat	36	9.77e-04	-0.318000	7.03e-03
HIV Transcription Elongation	36	9.77e-04	-0.318000	7.03e-03
Tat-mediated elongation of the HIV-1 transcript	36	9.77e-04	-0.318000	7.03e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	19	1.68e-02	-0.317000	6.03e-02
Role of phospholipids in phagocytosis	16	2.83e-02	-0.317000	8.84e-02
Degradation of GLI1 by the proteasome	51	9.34e-05	-0.316000	1.63e-03
Lagging Strand Synthesis	17	2.40e-02	-0.316000	7.87e-02
Autodegradation of the E3 ubiquitin ligase COP1	44	2.91e-04	-0.316000	3.04e-03
Negative regulation of NOTCH4 signaling	48	1.56e-04	-0.316000	2.02e-03
ERKs are inactivated	11	7.02e-02	-0.315000	1.67e-01
Transcription of the HIV genome	57	4.18e-05	-0.314000	9.13e-04
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	13	5.00e-02	-0.314000	1.35e-01
B-WICH complex positively regulates rRNA expression	27	4.84e-03	-0.313000	2.16e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	6.11e-02	-0.312000	1.53e-01
Elevation of cytosolic Ca2+ levels	10	8.77e-02	-0.312000	1.97e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	26	5.95e-03	-0.312000	2.51e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter	27	5.21e-03	-0.311000	2.29e-02
Degradation of AXIN	47	2.40e-04	-0.310000	2.64e-03
Vif-mediated degradation of APOBEC3G	43	4.52e-04	-0.309000	4.05e-03
Diseases associated with N-glycosylation of proteins	18	2.31e-02	-0.309000	7.70e-02
Glycogen synthesis	11	7.68e-02	-0.308000	1.79e-01
Vpr-mediated nuclear import of PICs	32	2.63e-03	-0.307000	1.39e-02
MicroRNA (miRNA) biogenesis	21	1.52e-02	-0.306000	5.48e-02
Formation of tubulin folding intermediates by CCT/TriC	14	4.74e-02	-0.306000	1.31e-01
Interleukin-7 signaling	14	4.76e-02	-0.306000	1.31e-01
Interleukin-35 Signalling	11	7.92e-02	-0.306000	1.82e-01
Loss of Nlp from mitotic centrosomes	56	8.80e-05	-0.303000	1.56e-03
Loss of proteins required for interphase microtubule organization from the centrosome	56	8.80e-05	-0.303000	1.56e-03
Prefoldin mediated transfer of substrate to CCT/TriC	17	3.11e-02	-0.302000	9.36e-02
NRIF signals cell death from the nucleus	14	5.06e-02	-0.302000	1.36e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	42	7.24e-04	-0.302000	5.80e-03
Interactions of Vpr with host cellular proteins	33	2.80e-03	-0.301000	1.45e-02
CLEC7A (Dectin-1) induces NFAT activation	11	8.42e-02	-0.301000	1.91e-01
RNA Polymerase II Pre-transcription Events	68	1.88e-05	-0.300000	5.45e-04
Formation of RNA Pol II elongation complex	50	2.41e-04	-0.300000	2.64e-03
RNA Polymerase II Transcription Elongation	50	2.41e-04	-0.300000	2.64e-03
Voltage gated Potassium channels	13	6.09e-02	0.300000	1.53e-01
Removal of the Flap Intermediate	12	7.27e-02	-0.299000	1.71e-01
Peptide ligand-binding receptors	20	2.08e-02	0.299000	7.09e-02
Dual incision in TC-NER	56	1.15e-04	-0.298000	1.75e-03
Vpu mediated degradation of CD4	44	6.53e-04	-0.297000	5.44e-03
Gap-filling DNA repair synthesis and ligation in TC-NER	55	1.45e-04	-0.296000	1.92e-03
SCF-beta-TrCP mediated degradation of Emi1	47	4.49e-04	-0.296000	4.05e-03
Telomere C-strand (Lagging Strand) Synthesis	29	5.93e-03	-0.295000	2.51e-02
Export of Viral Ribonucleoproteins from Nucleus	31	4.53e-03	-0.295000	2.03e-02
Hedgehog ligand biogenesis	52	2.40e-04	-0.295000	2.64e-03
RNA Polymerase III Transcription Termination	21	1.96e-02	-0.294000	6.78e-02
Regulation of PTEN mRNA translation	11	9.15e-02	0.294000	2.02e-01
Regulation of Apoptosis	45	6.56e-04	-0.294000	5.44e-03
Anchoring of the basal body to the plasma membrane	80	6.34e-06	-0.292000	2.18e-04
G1/S DNA Damage Checkpoints	58	1.26e-04	-0.291000	1.75e-03
TRAF3-dependent IRF activation pathway	14	6.02e-02	-0.290000	1.53e-01
ER-Phagosome pathway	69	3.21e-05	-0.290000	7.57e-04
RAF-independent MAPK1/3 activation	20	2.55e-02	-0.289000	8.21e-02
Regulation of ornithine decarboxylase (ODC)	43	1.08e-03	-0.288000	7.59e-03
Regulation of RUNX2 expression and activity	57	1.77e-04	-0.287000	2.22e-03
Transport of the SLBP Dependant Mature mRNA	34	3.76e-03	-0.287000	1.80e-02
Cyclin E associated events during G1/S transition	72	2.72e-05	-0.286000	7.14e-04
Nuclear import of Rev protein	31	5.86e-03	-0.286000	2.50e-02
Transport of the SLBP independent Mature mRNA	33	4.53e-03	-0.286000	2.03e-02
GAB1 signalosome	10	1.18e-01	-0.286000	2.41e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	46	8.12e-04	-0.285000	6.42e-03
Signaling by NTRK2 (TRKB)	15	5.60e-02	-0.285000	1.47e-01
Regulation of RAS by GAPs	56	2.28e-04	-0.285000	2.61e-03
Notch-HLH transcription pathway	21	2.41e-02	-0.284000	7.89e-02
Glucose metabolism	72	3.15e-05	-0.284000	7.57e-04
Polymerase switching on the C-strand of the telomere	22	2.16e-02	-0.283000	7.30e-02
Ovarian tumor domain proteases	29	8.54e-03	-0.282000	3.42e-02
RORA activates gene expression	11	1.07e-01	-0.281000	2.25e-01
Telomere C-strand synthesis initiation	10	1.25e-01	-0.280000	2.50e-01
Cyclin A:Cdk2-associated events at S phase entry	74	3.11e-05	-0.280000	7.57e-04
VEGFR2 mediated cell proliferation	16	5.28e-02	-0.280000	1.40e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	16	5.36e-02	-0.279000	1.41e-01
Leading Strand Synthesis	12	9.61e-02	-0.277000	2.09e-01
Polymerase switching	12	9.61e-02	-0.277000	2.09e-01
p53-Dependent G1 DNA Damage Response	56	3.43e-04	-0.277000	3.37e-03
p53-Dependent G1/S DNA damage checkpoint	56	3.43e-04	-0.277000	3.37e-03
HCMV Early Events	50	7.31e-04	-0.276000	5.82e-03
TP53 Regulates Transcription of DNA Repair Genes	52	5.83e-04	-0.276000	5.08e-03
Heme signaling	26	1.51e-02	-0.275000	5.48e-02
NEP/NS2 Interacts with the Cellular Export Machinery	30	9.16e-03	-0.275000	3.60e-02
Synaptic adhesion-like molecules	10	1.32e-01	0.275000	2.63e-01
Transcriptional regulation by small RNAs	45	1.47e-03	-0.274000	8.83e-03
Platelet calcium homeostasis	17	5.06e-02	-0.274000	1.36e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	20	3.56e-02	-0.271000	1.04e-01
Neurodegenerative Diseases	20	3.56e-02	-0.271000	1.04e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	6.91e-02	-0.271000	1.67e-01
Antigen processing-Cross presentation	76	4.53e-05	-0.271000	9.72e-04
Postmitotic nuclear pore complex (NPC) reformation	26	1.71e-02	-0.270000	6.12e-02
Diseases of programmed cell death	37	4.49e-03	-0.270000	2.03e-02
AURKA Activation by TPX2	59	3.52e-04	-0.269000	3.41e-03
G1/S-Specific Transcription	27	1.55e-02	-0.269000	5.59e-02
HDR through Single Strand Annealing (SSA)	35	5.92e-03	-0.269000	2.51e-02
Hh mutants abrogate ligand secretion	49	1.14e-03	-0.269000	7.72e-03
Regulation of RUNX3 expression and activity	49	1.15e-03	-0.269000	7.73e-03
Early Phase of HIV Life Cycle	13	9.42e-02	-0.268000	2.06e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	69	1.23e-04	-0.267000	1.75e-03
SUMOylation of SUMOylation proteins	32	8.93e-03	-0.267000	3.53e-02
Dectin-1 mediated noncanonical NF-kB signaling	52	8.69e-04	-0.267000	6.57e-03
The role of GTSE1 in G2/M progression after G2 checkpoint	52	8.74e-04	-0.267000	6.57e-03
DNA strand elongation	28	1.47e-02	-0.266000	5.38e-02
Processive synthesis on the C-strand of the telomere	17	5.75e-02	-0.266000	1.48e-01
Degradation of beta-catenin by the destruction complex	68	1.49e-04	-0.266000	1.95e-03
Degradation of DVL	48	1.46e-03	-0.266000	8.83e-03
Triglyceride catabolism	11	1.28e-01	-0.265000	2.55e-01
Stabilization of p53	49	1.35e-03	-0.265000	8.45e-03
Signaling by FGFR in disease	39	4.23e-03	-0.265000	1.92e-02
Asymmetric localization of PCP proteins	51	1.10e-03	-0.264000	7.59e-03
mRNA Splicing - Minor Pathway	49	1.38e-03	-0.264000	8.55e-03
NIK–>noncanonical NF-kB signaling	51	1.11e-03	-0.264000	7.59e-03
Base-Excision Repair, AP Site Formation	15	7.70e-02	-0.264000	1.79e-01
Hh mutants are degraded by ERAD	47	1.77e-03	-0.264000	1.02e-02
Mismatch Repair	13	1.00e-01	-0.263000	2.14e-01
Interleukin-6 signaling	10	1.51e-01	-0.263000	2.84e-01
DNA Damage/Telomere Stress Induced Senescence	24	2.60e-02	-0.263000	8.32e-02
Elastic fibre formation	17	6.10e-02	0.262000	1.53e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	14	8.92e-02	-0.262000	1.99e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	14	8.92e-02	-0.262000	1.99e-01
Signaling by NOTCH4	68	1.88e-04	-0.262000	2.27e-03
Host Interactions of HIV factors	106	3.46e-06	-0.261000	1.30e-04
Diseases associated with glycosylation precursor biosynthesis	15	8.03e-02	-0.261000	1.84e-01
Synthesis of IP3 and IP4 in the cytosol	16	7.10e-02	-0.261000	1.68e-01
Rap1 signalling	11	1.36e-01	-0.260000	2.66e-01
Defective Intrinsic Pathway for Apoptosis	23	3.13e-02	-0.259000	9.39e-02
Transport of Ribonucleoproteins into the Host Nucleus	30	1.40e-02	-0.259000	5.17e-02
RIPK1-mediated regulated necrosis	25	2.50e-02	-0.259000	8.09e-02
Regulation of necroptotic cell death	25	2.50e-02	-0.259000	8.09e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	10	1.56e-01	0.259000	2.89e-01
Ub-specific processing proteases	134	2.56e-07	-0.258000	1.40e-05
TP53 Regulates Transcription of Cell Cycle Genes	43	3.41e-03	-0.258000	1.68e-02
Glyoxylate metabolism and glycine degradation	19	5.14e-02	-0.258000	1.36e-01
Nuclear events mediated by NFE2L2	67	2.65e-04	-0.258000	2.84e-03
Beta-catenin phosphorylation cascade	15	8.46e-02	-0.257000	1.91e-01
Resolution of Sister Chromatid Cohesion	92	2.12e-05	-0.257000	5.92e-04
Cobalamin (Cbl, vitamin B12) transport and metabolism	11	1.40e-01	-0.257000	2.70e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	10	1.61e-01	-0.256000	2.95e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	63	4.46e-04	-0.256000	4.05e-03
Collagen degradation	14	9.91e-02	0.255000	2.13e-01
Formation of TC-NER Pre-Incision Complex	46	2.95e-03	-0.254000	1.50e-02
RNA Polymerase III Chain Elongation	17	7.07e-02	-0.253000	1.68e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	28	2.05e-02	-0.253000	7.00e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	28	2.05e-02	-0.253000	7.00e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	8.98e-02	-0.253000	1.99e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	62	5.92e-04	-0.252000	5.12e-03
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	18	6.39e-02	-0.252000	1.59e-01
Separation of Sister Chromatids	147	1.47e-07	-0.252000	9.28e-06
Regulation of expression of SLITs and ROBOs	124	1.37e-06	-0.251000	5.75e-05
Influenza Infection	130	7.70e-07	-0.251000	3.56e-05
tRNA Aminoacylation	23	3.75e-02	-0.251000	1.09e-01
Telomere Maintenance	57	1.10e-03	-0.250000	7.59e-03
RNA Polymerase I Transcription Termination	25	3.09e-02	-0.249000	9.33e-02
CLEC7A (Dectin-1) signaling	84	8.06e-05	-0.249000	1.51e-03
APC/C:Cdc20 mediated degradation of mitotic proteins	65	5.34e-04	-0.249000	4.72e-03
PCNA-Dependent Long Patch Base Excision Repair	18	6.85e-02	-0.248000	1.66e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	45	4.14e-03	-0.247000	1.89e-02
Vitamin B5 (pantothenate) metabolism	11	1.56e-01	-0.247000	2.89e-01
Sema4D induced cell migration and growth-cone collapse	12	1.39e-01	0.247000	2.70e-01
RNA Polymerase I Promoter Escape	27	2.66e-02	-0.247000	8.43e-02
HIV Life Cycle	129	1.39e-06	-0.247000	5.75e-05
Mitochondrial tRNA aminoacylation	18	7.03e-02	-0.246000	1.67e-01
SARS-CoV-2 modulates autophagy	11	1.57e-01	-0.246000	2.89e-01
APC truncation mutants have impaired AXIN binding	12	1.40e-01	-0.246000	2.70e-01
AXIN missense mutants destabilize the destruction complex	12	1.40e-01	-0.246000	2.70e-01
Signaling by AMER1 mutants	12	1.40e-01	-0.246000	2.70e-01
Signaling by APC mutants	12	1.40e-01	-0.246000	2.70e-01
Signaling by AXIN mutants	12	1.40e-01	-0.246000	2.70e-01
Truncations of AMER1 destabilize the destruction complex	12	1.40e-01	-0.246000	2.70e-01
MAPK6/MAPK4 signaling	69	4.11e-04	-0.246000	3.83e-03
Base Excision Repair	38	8.73e-03	-0.246000	3.48e-02
G-protein activation	13	1.25e-01	0.246000	2.50e-01
Signaling by ALK	18	7.15e-02	-0.245000	1.69e-01
Late Phase of HIV Life Cycle	117	5.20e-06	-0.244000	1.84e-04
Influenza Viral RNA Transcription and Replication	113	7.73e-06	-0.244000	2.58e-04
Metabolism of polyamines	48	3.53e-03	-0.244000	1.72e-02
UCH proteinases	74	2.97e-04	-0.243000	3.08e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	83	1.29e-04	-0.243000	1.75e-03
Amplification of signal from the kinetochores	83	1.29e-04	-0.243000	1.75e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	66	6.36e-04	-0.243000	5.38e-03
Chromosome Maintenance	78	2.07e-04	-0.243000	2.39e-03
Resolution of Abasic Sites (AP sites)	31	1.92e-02	-0.243000	6.69e-02
Recruitment of NuMA to mitotic centrosomes	65	7.08e-04	-0.243000	5.75e-03
Glycolysis	57	1.52e-03	-0.243000	9.01e-03
Signaling by FLT3 ITD and TKD mutants	12	1.45e-01	-0.243000	2.77e-01
G2/M DNA damage checkpoint	54	2.04e-03	-0.243000	1.13e-02
Interleukin-1 signaling	79	1.94e-04	-0.243000	2.31e-03
APC/C:Cdc20 mediated degradation of Securin	58	1.43e-03	-0.242000	8.77e-03
FCERI mediated NF-kB activation	64	8.58e-04	-0.241000	6.56e-03
Defective pyroptosis	10	1.89e-01	-0.240000	3.35e-01
Diseases of DNA repair	45	5.39e-03	-0.240000	2.33e-02
Activation of NF-kappaB in B cells	57	1.75e-03	-0.240000	1.02e-02
Nucleotide Excision Repair	99	4.05e-05	-0.239000	9.13e-04
SUMOylation of intracellular receptors	19	7.21e-02	-0.238000	1.70e-01
NS1 Mediated Effects on Host Pathways	38	1.12e-02	-0.238000	4.30e-02
RUNX3 regulates NOTCH signaling	11	1.73e-01	-0.237000	3.11e-01
HIV Infection	190	1.91e-08	-0.237000	1.77e-06
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	1.01e-01	-0.237000	2.16e-01
G1/S Transition	115	1.20e-05	-0.237000	3.81e-04
G0 and Early G1	24	4.50e-02	-0.236000	1.27e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	53	3.02e-03	-0.236000	1.53e-02
Signaling by NOTCH2	18	8.36e-02	-0.236000	1.90e-01
Retrograde transport at the Trans-Golgi-Network	45	6.45e-03	-0.235000	2.67e-02
TBC/RABGAPs	40	1.05e-02	-0.234000	4.06e-02
Potassium Channels	30	2.68e-02	0.234000	8.47e-02
Cellular response to hypoxia	60	1.76e-03	-0.234000	1.02e-02
Defective CFTR causes cystic fibrosis	52	3.60e-03	-0.233000	1.74e-02
Regulation of TP53 Activity through Phosphorylation	79	3.45e-04	-0.233000	3.37e-03
Autodegradation of Cdh1 by Cdh1:APC/C	56	2.57e-03	-0.233000	1.37e-02
Caspase activation via Death Receptors in the presence of ligand	10	2.03e-01	-0.232000	3.55e-01
SUMOylation of ubiquitinylation proteins	37	1.48e-02	-0.232000	5.39e-02
RUNX3 regulates p14-ARF	10	2.05e-01	-0.231000	3.57e-01
Mitotic Prometaphase	158	5.78e-07	-0.231000	2.78e-05
Estrogen-dependent gene expression	70	8.51e-04	-0.231000	6.56e-03
Transport of Mature Transcript to Cytoplasm	64	1.44e-03	-0.231000	8.77e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	88	1.89e-04	-0.231000	2.27e-03
Nonsense-Mediated Decay (NMD)	88	1.89e-04	-0.231000	2.27e-03
Translesion synthesis by POLI	15	1.22e-01	-0.230000	2.47e-01
Class A/1 (Rhodopsin-like receptors)	49	5.34e-03	0.230000	2.32e-02
Positive epigenetic regulation of rRNA expression	40	1.19e-02	-0.230000	4.51e-02
Deposition of new CENPA-containing nucleosomes at the centromere	23	5.64e-02	-0.230000	1.47e-01
Nucleosome assembly	23	5.64e-02	-0.230000	1.47e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	11	1.87e-01	-0.230000	3.32e-01
CDK-mediated phosphorylation and removal of Cdc6	62	1.77e-03	-0.230000	1.02e-02
RNA Polymerase I Transcription Initiation	40	1.26e-02	-0.228000	4.73e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	74	7.07e-04	-0.228000	5.75e-03
CTNNB1 S33 mutants aren’t phosphorylated	13	1.55e-01	-0.228000	2.88e-01
CTNNB1 S37 mutants aren’t phosphorylated	13	1.55e-01	-0.228000	2.88e-01
CTNNB1 S45 mutants aren’t phosphorylated	13	1.55e-01	-0.228000	2.88e-01
CTNNB1 T41 mutants aren’t phosphorylated	13	1.55e-01	-0.228000	2.88e-01
Signaling by CTNNB1 phospho-site mutants	13	1.55e-01	-0.228000	2.88e-01
Signaling by GSK3beta mutants	13	1.55e-01	-0.228000	2.88e-01
Deubiquitination	198	3.72e-08	-0.228000	2.80e-06
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	1.74e-01	-0.227000	3.11e-01
Mitotic G1 phase and G1/S transition	129	9.08e-06	-0.227000	2.95e-04
Hedgehog ‘on’ state	63	1.95e-03	-0.226000	1.09e-02
RHO GTPases Activate Formins	102	8.45e-05	-0.226000	1.54e-03
TNFR1-induced NFkappaB signaling pathway	20	8.08e-02	-0.226000	1.85e-01
tRNA processing in the nucleus	55	3.87e-03	-0.225000	1.82e-02
Downstream signaling events of B Cell Receptor (BCR)	70	1.13e-03	-0.225000	7.72e-03
KEAP1-NFE2L2 pathway	86	3.25e-04	-0.224000	3.31e-03
Gene Silencing by RNA	62	2.26e-03	-0.224000	1.24e-02
Polo-like kinase mediated events	15	1.34e-01	-0.224000	2.65e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	57	3.52e-03	-0.224000	1.72e-02
EML4 and NUDC in mitotic spindle formation	87	3.29e-04	-0.223000	3.32e-03
Signaling by ROBO receptors	154	1.89e-06	-0.223000	7.58e-05
Signaling by EGFR in Cancer	16	1.25e-01	-0.222000	2.50e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	23	6.60e-02	-0.221000	1.62e-01
Centrosome maturation	66	1.92e-03	-0.221000	1.08e-02
Recruitment of mitotic centrosome proteins and complexes	66	1.92e-03	-0.221000	1.08e-02
Orc1 removal from chromatin	62	2.66e-03	-0.221000	1.40e-02
Regulation of APC/C activators between G1/S and early anaphase	70	1.44e-03	-0.220000	8.77e-03
Downstream signal transduction	20	8.84e-02	-0.220000	1.98e-01
Purine catabolism	10	2.28e-01	-0.220000	3.86e-01
Diseases associated with O-glycosylation of proteins	21	8.09e-02	0.220000	1.85e-01
Dual Incision in GG-NER	35	2.46e-02	-0.220000	8.00e-02
Transcription of E2F targets under negative control by DREAM complex	18	1.07e-01	-0.219000	2.26e-01
Pyruvate metabolism	20	8.99e-02	-0.219000	1.99e-01
Hedgehog ‘off’ state	75	1.07e-03	-0.219000	7.59e-03
RNA Polymerase III Abortive And Retractive Initiation	39	1.82e-02	-0.219000	6.41e-02
RNA Polymerase III Transcription	39	1.82e-02	-0.219000	6.41e-02
Impaired BRCA2 binding to RAD51	32	3.28e-02	-0.218000	9.74e-02
Negative regulators of DDX58/IFIH1 signaling	34	2.78e-02	-0.218000	8.73e-02
ABC transporter disorders	59	3.82e-03	-0.218000	1.81e-02
Meiotic recombination	19	1.00e-01	-0.218000	2.14e-01
Regulation of PLK1 Activity at G2/M Transition	74	1.22e-03	-0.218000	7.94e-03
CD28 dependent PI3K/Akt signaling	18	1.10e-01	-0.218000	2.29e-01
ERK/MAPK targets	16	1.32e-01	-0.217000	2.63e-01
Condensation of Prometaphase Chromosomes	10	2.36e-01	-0.217000	3.95e-01
G2/M Checkpoints	119	4.63e-05	-0.217000	9.77e-04
Glycogen metabolism	17	1.22e-01	-0.216000	2.47e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	48	9.69e-03	-0.216000	3.78e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	84	6.46e-04	-0.216000	5.43e-03
SRP-dependent cotranslational protein targeting to membrane	88	4.84e-04	-0.215000	4.31e-03
Selenoamino acid metabolism	78	1.05e-03	-0.215000	7.46e-03
Mitotic Metaphase and Anaphase	196	2.44e-07	-0.214000	1.40e-05
p75NTR signals via NF-kB	11	2.18e-01	-0.214000	3.73e-01
APC/C-mediated degradation of cell cycle proteins	77	1.17e-03	-0.214000	7.75e-03
Regulation of mitotic cell cycle	77	1.17e-03	-0.214000	7.75e-03
Cleavage of the damaged pyrimidine	14	1.65e-01	-0.214000	3.00e-01
Depyrimidination	14	1.65e-01	-0.214000	3.00e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	14	1.65e-01	-0.214000	3.00e-01
Sema4D in semaphorin signaling	15	1.51e-01	0.214000	2.85e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	41	1.78e-02	-0.214000	6.33e-02
S Phase	141	1.25e-05	-0.214000	3.85e-04
Diseases associated with glycosaminoglycan metabolism	16	1.40e-01	-0.213000	2.70e-01
Mitotic Anaphase	195	3.32e-07	-0.213000	1.74e-05
Long-term potentiation	11	2.22e-01	0.212000	3.78e-01
LDL clearance	12	2.04e-01	-0.212000	3.56e-01
Cap-dependent Translation Initiation	95	3.80e-04	-0.211000	3.59e-03
Eukaryotic Translation Initiation	95	3.80e-04	-0.211000	3.59e-03
Processing of DNA double-strand break ends	55	6.80e-03	-0.211000	2.79e-02
Homology Directed Repair	90	5.63e-04	-0.211000	4.94e-03
Ion homeostasis	26	6.38e-02	-0.210000	1.59e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	64	3.79e-03	-0.209000	1.80e-02
Eukaryotic Translation Termination	72	2.15e-03	-0.209000	1.18e-02
Citric acid cycle (TCA cycle)	19	1.16e-01	-0.208000	2.39e-01
Nuclear Pore Complex (NPC) Disassembly	34	3.57e-02	-0.208000	1.04e-01
Eukaryotic Translation Elongation	72	2.29e-03	-0.208000	1.25e-02
Signaling by NTRK3 (TRKC)	11	2.32e-01	-0.208000	3.91e-01
InlB-mediated entry of Listeria monocytogenes into host cell	11	2.32e-01	-0.208000	3.91e-01
Signaling by Retinoic Acid	17	1.38e-01	-0.208000	2.70e-01
HCMV Infection	71	2.59e-03	-0.207000	1.38e-02
Downstream TCR signaling	71	2.63e-03	-0.207000	1.39e-02
Selenocysteine synthesis	70	2.85e-03	-0.206000	1.47e-02
Regulation of pyruvate dehydrogenase (PDH) complex	11	2.36e-01	-0.206000	3.95e-01
Cell Cycle Checkpoints	228	9.43e-08	-0.206000	6.67e-06
Mitotic Spindle Checkpoint	98	4.37e-04	-0.206000	4.01e-03
Cyclin A/B1/B2 associated events during G2/M transition	22	9.65e-02	-0.205000	2.09e-01
Activation of HOX genes during differentiation	41	2.35e-02	-0.205000	7.78e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis	41	2.35e-02	-0.205000	7.78e-02
COPI-mediated anterograde transport	71	2.95e-03	-0.204000	1.50e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	77	2.01e-03	-0.204000	1.12e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus	15	1.72e-01	-0.204000	3.10e-01
Signaling by FGFR2	48	1.47e-02	-0.204000	5.38e-02
RHO GTPases activate CIT	14	1.87e-01	-0.204000	3.33e-01
M Phase	297	2.01e-09	-0.203000	2.01e-07
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	20	1.17e-01	-0.202000	2.40e-01
Glutathione conjugation	21	1.09e-01	-0.202000	2.27e-01
Mitochondrial Fatty Acid Beta-Oxidation	26	7.47e-02	-0.202000	1.75e-01
Triglyceride metabolism	16	1.62e-01	-0.202000	2.96e-01
Removal of the Flap Intermediate from the C-strand	15	1.77e-01	-0.201000	3.17e-01
Activation of gene expression by SREBF (SREBP)	36	3.68e-02	-0.201000	1.07e-01
Thrombin signalling through proteinase activated receptors (PARs)	20	1.19e-01	0.201000	2.43e-01
RNA polymerase II transcribes snRNA genes	71	3.47e-03	-0.201000	1.70e-02
Transcriptional regulation by RUNX3	75	2.69e-03	-0.201000	1.41e-02
Peptide chain elongation	69	4.03e-03	-0.200000	1.85e-02
Mitotic G2-G2/M phases	158	1.51e-05	-0.200000	4.55e-04
Homologous DNA Pairing and Strand Exchange	39	3.10e-02	-0.200000	9.33e-02
Metabolism of carbohydrates	181	3.82e-06	-0.200000	1.39e-04
Organelle biogenesis and maintenance	204	9.52e-07	-0.200000	4.24e-05
DNA Double-Strand Break Repair	117	1.97e-04	-0.200000	2.32e-03
Prostacyclin signalling through prostacyclin receptor	12	2.32e-01	0.199000	3.91e-01
Translesion synthesis by REV1	14	1.98e-01	-0.199000	3.47e-01
Translation	238	1.46e-07	-0.199000	9.28e-06
Class I peroxisomal membrane protein import	19	1.34e-01	-0.199000	2.65e-01
Cilium Assembly	150	2.85e-05	-0.198000	7.28e-04
Apoptosis	133	8.20e-05	-0.198000	1.52e-03
Mitochondrial biogenesis	54	1.18e-02	-0.198000	4.50e-02
Formation of Incision Complex in GG-NER	36	4.01e-02	-0.198000	1.15e-01
Transcriptional regulation by RUNX2	84	1.78e-03	-0.197000	1.02e-02
HDR through Homologous Recombination (HRR)	60	8.45e-03	-0.197000	3.39e-02
G2/M Transition	156	2.35e-05	-0.197000	6.43e-04
Nuclear Receptor transcription pathway	27	7.81e-02	-0.196000	1.81e-01
Arachidonic acid metabolism	21	1.20e-01	0.196000	2.44e-01
Viral mRNA Translation	69	5.02e-03	-0.196000	2.22e-02
Depolymerisation of the Nuclear Lamina	13	2.22e-01	0.195000	3.78e-01
Diseases of mitotic cell cycle	34	4.88e-02	-0.195000	1.34e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	58	1.05e-02	-0.194000	4.06e-02
Signaling by the B Cell Receptor (BCR)	90	1.47e-03	-0.194000	8.83e-03
Formation of a pool of free 40S subunits	78	3.08e-03	-0.194000	1.55e-02
Mitochondrial iron-sulfur cluster biogenesis	12	2.46e-01	-0.194000	4.08e-01
RNA Polymerase I Promoter Clearance	44	2.64e-02	-0.194000	8.40e-02
RNA Polymerase I Transcription	44	2.64e-02	-0.194000	8.40e-02
Nucleotide biosynthesis	12	2.46e-01	-0.193000	4.08e-01
tRNA processing	93	1.30e-03	-0.193000	8.28e-03
ABC-family proteins mediated transport	74	4.10e-03	-0.193000	1.88e-02
Global Genome Nucleotide Excision Repair (GG-NER)	76	3.71e-03	-0.193000	1.78e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation	23	1.10e-01	-0.193000	2.28e-01
Synthesis of DNA	106	6.30e-04	-0.192000	5.37e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency	78	3.41e-03	-0.192000	1.68e-02
Intrinsic Pathway for Apoptosis	47	2.29e-02	-0.192000	7.66e-02
Signaling by ERBB2 KD Mutants	12	2.50e-01	-0.192000	4.13e-01
C-type lectin receptors (CLRs)	100	9.71e-04	-0.191000	7.03e-03
SUMOylation of DNA replication proteins	43	3.03e-02	-0.191000	9.28e-02
ABC transporters in lipid homeostasis	10	2.96e-01	0.191000	4.66e-01
Meiosis	42	3.28e-02	-0.190000	9.74e-02
COPI-dependent Golgi-to-ER retrograde traffic	66	7.53e-03	-0.190000	3.06e-02
Regulated Necrosis	43	3.09e-02	-0.190000	9.33e-02
Methylation	10	2.98e-01	-0.190000	4.67e-01
RNA Polymerase III Transcription Initiation	35	5.18e-02	-0.190000	1.37e-01
Cell Cycle, Mitotic	425	2.80e-11	-0.190000	4.80e-09
Golgi-to-ER retrograde transport	95	1.50e-03	-0.189000	8.96e-03
Constitutive Signaling by AKT1 E17K in Cancer	23	1.17e-01	-0.189000	2.40e-01
Unwinding of DNA	11	2.79e-01	-0.189000	4.48e-01
Interleukin-1 family signaling	99	1.21e-03	-0.188000	7.94e-03
Metabolism of non-coding RNA	48	2.42e-02	-0.188000	7.89e-02
snRNP Assembly	48	2.42e-02	-0.188000	7.89e-02
RHO GTPases activate PKNs	26	9.75e-02	-0.188000	2.10e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	88	2.38e-03	-0.188000	1.29e-02
DNA Repair	248	4.03e-07	-0.188000	2.02e-05
Cellular response to chemical stress	145	1.02e-04	-0.187000	1.70e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	88	2.48e-03	-0.187000	1.34e-02
Cytoprotection by HMOX1	44	3.21e-02	-0.187000	9.59e-02
TICAM1-dependent activation of IRF3/IRF7	12	2.64e-01	-0.186000	4.28e-01
Cell Cycle	530	4.69e-13	-0.185000	1.41e-10
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	83	3.67e-03	-0.185000	1.77e-02
Metabolism of water-soluble vitamins and cofactors	82	3.92e-03	-0.184000	1.82e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	33	6.69e-02	-0.184000	1.64e-01
Presynaptic phase of homologous DNA pairing and strand exchange	36	5.61e-02	-0.184000	1.47e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	55	1.87e-02	-0.183000	6.55e-02
RHOD GTPase cycle	36	5.70e-02	0.183000	1.47e-01
Translesion synthesis by POLK	15	2.19e-01	-0.183000	3.74e-01
COPI-independent Golgi-to-ER retrograde traffic	29	8.86e-02	-0.183000	1.98e-01
Cell-cell junction organization	13	2.54e-01	0.183000	4.18e-01
PCP/CE pathway	71	8.05e-03	-0.182000	3.26e-02
Translesion Synthesis by POLH	17	1.94e-01	-0.182000	3.42e-01
Circadian Clock	52	2.36e-02	-0.182000	7.78e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	13	2.59e-01	-0.181000	4.22e-01
The citric acid (TCA) cycle and respiratory electron transport	121	6.11e-04	-0.181000	5.25e-03
Semaphorin interactions	39	5.11e-02	0.181000	1.36e-01
HATs acetylate histones	63	1.34e-02	-0.180000	4.97e-02
Intra-Golgi and retrograde Golgi-to-ER traffic	158	1.12e-04	-0.178000	1.75e-03
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	29	9.66e-02	0.178000	2.09e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	16	2.18e-01	-0.178000	3.73e-01
L13a-mediated translational silencing of Ceruloplasmin expression	87	4.22e-03	-0.178000	1.92e-02
Miscellaneous transport and binding events	14	2.50e-01	-0.178000	4.13e-01
GPCR ligand binding	80	6.11e-03	0.178000	2.55e-02
Regulation of IFNA/IFNB signaling	12	2.87e-01	-0.177000	4.58e-01
Programmed Cell Death	155	1.45e-04	-0.177000	1.92e-03
Respiratory electron transport	82	5.69e-03	-0.177000	2.43e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects	33	7.92e-02	-0.177000	1.82e-01
Translation of Structural Proteins	27	1.12e-01	-0.177000	2.33e-01
Keratan sulfate biosynthesis	14	2.54e-01	-0.176000	4.18e-01
DAG and IP3 signaling	26	1.20e-01	-0.176000	2.44e-01
Signaling by Hedgehog	99	2.55e-03	-0.176000	1.37e-02
Complex I biogenesis	43	4.67e-02	-0.175000	1.31e-01
Diseases of signal transduction by growth factor receptors and second messengers	299	2.11e-07	-0.175000	1.27e-05
Signalling to RAS	12	2.94e-01	-0.175000	4.66e-01
Extension of Telomeres	44	4.49e-02	-0.175000	1.27e-01
Post-chaperonin tubulin folding pathway	13	2.77e-01	-0.174000	4.45e-01
Aggrephagy	19	1.90e-01	-0.174000	3.36e-01
Switching of origins to a post-replicative state	81	6.94e-03	-0.174000	2.84e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	37	6.76e-02	-0.174000	1.64e-01
Diseases of DNA Double-Strand Break Repair	37	6.76e-02	-0.174000	1.64e-01
Signaling by FGFR	52	3.06e-02	-0.173000	9.32e-02
Sema3A PAK dependent Axon repulsion	11	3.19e-01	0.173000	4.94e-01
ISG15 antiviral mechanism	70	1.24e-02	-0.173000	4.66e-02
ESR-mediated signaling	115	1.38e-03	-0.173000	8.55e-03
DNA Replication	113	1.54e-03	-0.173000	9.07e-03
Activation of BAD and translocation to mitochondria	14	2.64e-01	-0.173000	4.27e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	10	3.45e-01	-0.173000	5.19e-01
Signaling by FLT3 fusion proteins	16	2.33e-01	-0.172000	3.91e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	35	7.82e-02	-0.172000	1.81e-01
SARS-CoV-2-host interactions	150	2.89e-04	-0.172000	3.04e-03
Regulation of TNFR1 signaling	31	9.84e-02	-0.172000	2.12e-01
Peroxisomal lipid metabolism	22	1.64e-01	-0.172000	2.98e-01
Termination of translesion DNA synthesis	28	1.17e-01	-0.171000	2.40e-01
RNA Polymerase II Transcription Termination	45	4.94e-02	-0.169000	1.35e-01
Recognition of DNA damage by PCNA-containing replication complex	26	1.36e-01	-0.169000	2.66e-01
Phase II - Conjugation of compounds	46	4.75e-02	-0.169000	1.31e-01
Activation of BH3-only proteins	27	1.30e-01	-0.169000	2.59e-01
Platelet sensitization by LDL	13	2.93e-01	-0.168000	4.66e-01
Metabolism of vitamins and cofactors	111	2.28e-03	-0.168000	1.24e-02
Signaling by Nuclear Receptors	151	4.00e-04	-0.167000	3.76e-03
Cargo trafficking to the periciliary membrane	40	6.74e-02	-0.167000	1.64e-01
G-protein mediated events	32	1.02e-01	-0.167000	2.16e-01
FLT3 signaling in disease	24	1.56e-01	-0.167000	2.89e-01
Inwardly rectifying K+ channels	13	2.97e-01	0.167000	4.66e-01
Glycosphingolipid metabolism	27	1.34e-01	-0.166000	2.65e-01
CD28 co-stimulation	27	1.34e-01	-0.166000	2.65e-01
Glycogen storage diseases	10	3.62e-01	-0.166000	5.36e-01
Negative epigenetic regulation of rRNA expression	44	5.66e-02	-0.166000	1.47e-01
Disease	1086	1.37e-19	-0.166000	1.65e-16
Metabolism of cofactors	17	2.38e-01	-0.165000	3.97e-01
Disorders of transmembrane transporters	111	2.74e-03	-0.165000	1.43e-02
SUMOylation of RNA binding proteins	42	6.49e-02	-0.165000	1.61e-01
ADP signalling through P2Y purinoceptor 1	16	2.55e-01	0.164000	4.19e-01
HDR through MMEJ (alt-NHEJ)	11	3.45e-01	-0.164000	5.19e-01
Assembly of the pre-replicative complex	76	1.36e-02	-0.164000	5.02e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	41	6.98e-02	-0.164000	1.67e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	41	6.98e-02	-0.164000	1.67e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	41	6.98e-02	-0.164000	1.67e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	41	6.98e-02	-0.164000	1.67e-01
Signaling by NOTCH1 in Cancer	41	6.98e-02	-0.164000	1.67e-01
IKK complex recruitment mediated by RIP1	17	2.43e-01	-0.164000	4.04e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	3.47e-01	-0.164000	5.21e-01
Interleukin-12 family signaling	42	6.74e-02	-0.163000	1.64e-01
HCMV Late Events	51	4.40e-02	-0.163000	1.25e-01
RHO GTPase Effectors	188	1.25e-04	-0.163000	1.75e-03
Post-translational modification: synthesis of GPI-anchored proteins	31	1.17e-01	-0.163000	2.40e-01
MHC class II antigen presentation	69	1.97e-02	-0.163000	6.78e-02
RAC3 GTPase cycle	59	3.09e-02	0.163000	9.33e-02
VxPx cargo-targeting to cilium	16	2.61e-01	-0.162000	4.23e-01
Chaperonin-mediated protein folding	57	3.42e-02	-0.162000	1.01e-01
DNA Replication Pre-Initiation	90	8.13e-03	-0.162000	3.28e-02
Nucleotide catabolism	21	2.00e-01	-0.161000	3.50e-01
Processing of Capped Intron-Containing Pre-mRNA	199	1.00e-04	-0.160000	1.70e-03
Infectious disease	627	1.38e-11	-0.160000	2.77e-09
Regulation of TP53 Activity	136	1.32e-03	-0.160000	8.38e-03
Metabolism of RNA	553	2.04e-10	-0.160000	3.06e-08
DNA Damage Bypass	42	7.35e-02	-0.160000	1.73e-01
Smooth Muscle Contraction	19	2.29e-01	-0.159000	3.87e-01
Metabolism of nucleotides	73	1.87e-02	-0.159000	6.55e-02
Protein folding	63	2.90e-02	-0.159000	9.02e-02
Transcriptional Regulation by TP53	302	2.36e-06	-0.159000	9.15e-05
Factors involved in megakaryocyte development and platelet production	87	1.09e-02	-0.158000	4.19e-02
Energy dependent regulation of mTOR by LKB1-AMPK	25	1.72e-01	-0.158000	3.10e-01
Metabolism of amino acids and derivatives	225	4.88e-05	-0.158000	1.01e-03
Major pathway of rRNA processing in the nucleolus and cytosol	152	8.26e-04	-0.158000	6.49e-03
Role of LAT2/NTAL/LAB on calcium mobilization	10	3.89e-01	-0.157000	5.58e-01
Selective autophagy	50	5.46e-02	-0.157000	1.43e-01
PERK regulates gene expression	26	1.66e-01	-0.157000	3.01e-01
Reproduction	48	6.09e-02	-0.156000	1.53e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	12	3.48e-01	-0.156000	5.21e-01
Fc epsilon receptor (FCERI) signaling	107	5.30e-03	-0.156000	2.31e-02
Cyclin D associated events in G1	41	8.38e-02	-0.156000	1.90e-01
G1 Phase	41	8.38e-02	-0.156000	1.90e-01
TNF signaling	38	9.63e-02	-0.156000	2.09e-01
p75 NTR receptor-mediated signalling	59	3.84e-02	-0.156000	1.11e-01
E3 ubiquitin ligases ubiquitinate target proteins	41	8.55e-02	-0.155000	1.93e-01
G beta:gamma signalling through BTK	11	3.73e-01	0.155000	5.45e-01
Thromboxane signalling through TP receptor	15	2.99e-01	0.155000	4.68e-01
Epigenetic regulation of gene expression	76	1.97e-02	-0.155000	6.78e-02
TCF dependent signaling in response to WNT	119	3.60e-03	-0.155000	1.74e-02
TNFR2 non-canonical NF-kB pathway	68	2.78e-02	-0.154000	8.73e-02
PLC beta mediated events	29	1.52e-01	-0.154000	2.85e-01
Signaling by EGFR	35	1.15e-01	-0.154000	2.39e-01
ZBP1(DAI) mediated induction of type I IFNs	17	2.74e-01	-0.153000	4.40e-01
Chaperone Mediated Autophagy	12	3.58e-01	-0.153000	5.31e-01
NOTCH1 Intracellular Domain Regulates Transcription	37	1.07e-01	-0.153000	2.26e-01
DNA Damage Recognition in GG-NER	35	1.19e-01	-0.152000	2.43e-01
Transcriptional Regulation by E2F6	29	1.56e-01	-0.152000	2.89e-01
Signaling by CSF3 (G-CSF)	24	1.98e-01	-0.152000	3.47e-01
Interleukin-20 family signaling	13	3.44e-01	-0.152000	5.19e-01
SHC1 events in ERBB2 signaling	11	3.84e-01	0.152000	5.55e-01
Apoptotic factor-mediated response	16	2.95e-01	-0.151000	4.66e-01
Nuclear Events (kinase and transcription factor activation)	42	9.03e-02	-0.151000	1.99e-01
SUMO E3 ligases SUMOylate target proteins	132	2.88e-03	-0.151000	1.48e-02
rRNA processing in the nucleus and cytosol	159	1.09e-03	-0.151000	7.59e-03
Golgi Associated Vesicle Biogenesis	38	1.09e-01	-0.150000	2.28e-01
Regulation of TP53 Degradation	33	1.36e-01	-0.150000	2.66e-01
MyD88-independent TLR4 cascade	74	2.59e-02	-0.150000	8.31e-02
TRIF(TICAM1)-mediated TLR4 signaling	74	2.59e-02	-0.150000	8.31e-02
rRNA processing	164	9.65e-04	-0.150000	7.03e-03
Regulation of TP53 Expression and Degradation	34	1.34e-01	-0.149000	2.65e-01
Deactivation of the beta-catenin transactivating complex	28	1.73e-01	-0.149000	3.11e-01
Activation of G protein gated Potassium channels	12	3.74e-01	0.148000	5.45e-01
G protein gated Potassium channels	12	3.74e-01	0.148000	5.45e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	12	3.74e-01	0.148000	5.45e-01
Toll Like Receptor 4 (TLR4) Cascade	94	1.32e-02	-0.148000	4.91e-02
Interleukin-4 and Interleukin-13 signaling	49	7.41e-02	-0.148000	1.74e-01
Mitochondrial protein import	48	7.74e-02	-0.147000	1.80e-01
Drug ADME	27	1.86e-01	-0.147000	3.32e-01
Plasma lipoprotein clearance	24	2.13e-01	-0.147000	3.67e-01
FOXO-mediated transcription of cell death genes	14	3.42e-01	-0.147000	5.19e-01
Peroxisomal protein import	48	7.90e-02	-0.147000	1.82e-01
ATF4 activates genes in response to endoplasmic reticulum stress	23	2.24e-01	-0.146000	3.80e-01
Protein localization	123	5.17e-03	-0.146000	2.27e-02
SUMOylation of DNA damage response and repair proteins	67	3.94e-02	-0.146000	1.13e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	14	3.46e-01	-0.145000	5.19e-01
Cellular response to starvation	120	6.02e-03	-0.145000	2.53e-02
Signaling by MET	41	1.08e-01	-0.145000	2.27e-01
Interferon alpha/beta signaling	51	7.40e-02	-0.145000	1.74e-01
AKT phosphorylates targets in the cytosol	13	3.67e-01	-0.144000	5.41e-01
Signaling by KIT in disease	16	3.18e-01	-0.144000	4.93e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	16	3.18e-01	-0.144000	4.93e-01
VLDLR internalisation and degradation	11	4.09e-01	-0.144000	5.76e-01
Formation of the ternary complex, and subsequently, the 43S complex	40	1.16e-01	-0.144000	2.39e-01
Interleukin-6 family signaling	13	3.70e-01	-0.144000	5.43e-01
Neddylation	188	7.21e-04	-0.143000	5.80e-03
NoRC negatively regulates rRNA expression	42	1.08e-01	-0.143000	2.27e-01
Signaling by ALK fusions and activated point mutants	46	9.29e-02	-0.143000	2.03e-01
Signaling by ALK in cancer	46	9.29e-02	-0.143000	2.03e-01
ER to Golgi Anterograde Transport	108	1.04e-02	-0.143000	4.03e-02
SARS-CoV-2 Infection	213	3.42e-04	-0.143000	3.37e-03
N-Glycan antennae elongation	10	4.34e-01	-0.143000	6.00e-01
Azathioprine ADME	15	3.40e-01	-0.142000	5.17e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	28	1.92e-01	-0.142000	3.40e-01
Plasma lipoprotein assembly, remodeling, and clearance	39	1.27e-01	-0.141000	2.54e-01
Interleukin-12 signaling	36	1.43e-01	-0.141000	2.74e-01
Metabolism of porphyrins	15	3.45e-01	-0.141000	5.19e-01
Cellular responses to stimuli	551	2.34e-08	-0.141000	2.01e-06
Downstream signaling of activated FGFR1	12	3.99e-01	-0.140000	5.69e-01
Downstream signaling of activated FGFR2	12	3.99e-01	-0.140000	5.69e-01
Downstream signaling of activated FGFR3	12	3.99e-01	-0.140000	5.69e-01
Downstream signaling of activated FGFR4	12	3.99e-01	-0.140000	5.69e-01
TP53 Regulates Metabolic Genes	71	4.11e-02	-0.140000	1.17e-01
MET promotes cell motility	13	3.82e-01	-0.140000	5.53e-01
Antiviral mechanism by IFN-stimulated genes	77	3.43e-02	-0.140000	1.01e-01
RAS processing	15	3.49e-01	-0.140000	5.21e-01
Signaling by NOTCH	135	5.27e-03	-0.139000	2.30e-02
SUMOylation	138	4.84e-03	-0.139000	2.16e-02
Death Receptor Signalling	96	1.86e-02	-0.139000	6.54e-02
Cellular responses to stress	546	3.64e-08	-0.139000	2.80e-06
Condensation of Prophase Chromosomes	12	4.04e-01	-0.139000	5.73e-01
Mitochondrial translation	89	2.38e-02	-0.139000	7.85e-02
Transport to the Golgi and subsequent modification	130	6.69e-03	-0.138000	2.76e-02
mRNA Splicing - Major Pathway	148	3.88e-03	-0.138000	1.82e-02
MyD88 dependent cascade initiated on endosome	67	5.13e-02	-0.138000	1.36e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	67	5.13e-02	-0.138000	1.36e-01
Regulation of beta-cell development	16	3.42e-01	-0.137000	5.19e-01
mRNA 3’-end processing	37	1.49e-01	-0.137000	2.84e-01
DNA Double Strand Break Response	36	1.56e-01	-0.137000	2.89e-01
Nuclear Envelope (NE) Reassembly	60	6.75e-02	-0.137000	1.64e-01
N-glycan antennae elongation in the medial/trans-Golgi	17	3.32e-01	-0.136000	5.07e-01
MyD88 cascade initiated on plasma membrane	65	5.83e-02	-0.136000	1.49e-01
Toll Like Receptor 10 (TLR10) Cascade	65	5.83e-02	-0.136000	1.49e-01
Toll Like Receptor 5 (TLR5) Cascade	65	5.83e-02	-0.136000	1.49e-01
Platelet degranulation	49	1.01e-01	-0.135000	2.16e-01
Regulation of HSF1-mediated heat shock response	67	5.63e-02	-0.135000	1.47e-01
Gene expression (Transcription)	1040	5.89e-13	-0.135000	1.42e-10
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	14	3.86e-01	-0.134000	5.58e-01
Resolution of D-Loop Structures	29	2.14e-01	-0.133000	3.68e-01
Molecules associated with elastic fibres	12	4.24e-01	0.133000	5.91e-01
Assembly of collagen fibrils and other multimeric structures	14	3.87e-01	0.133000	5.58e-01
mRNA Splicing	158	3.90e-03	-0.133000	1.82e-02
PRC2 methylates histones and DNA	12	4.24e-01	-0.133000	5.91e-01
Deadenylation-dependent mRNA decay	52	9.71e-02	-0.133000	2.10e-01
Class I MHC mediated antigen processing & presentation	289	1.12e-04	-0.133000	1.75e-03
Kinesins	32	1.95e-01	-0.133000	3.42e-01
Toll Like Receptor 3 (TLR3) Cascade	74	4.92e-02	-0.132000	1.35e-01
RHOG GTPase cycle	49	1.09e-01	0.132000	2.28e-01
Heme biosynthesis	10	4.69e-01	-0.132000	6.31e-01
Response to elevated platelet cytosolic Ca2+	53	9.74e-02	-0.132000	2.10e-01
Metabolism of proteins	1246	2.53e-14	-0.131000	1.52e-11
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	24	2.66e-01	-0.131000	4.30e-01
RMTs methylate histone arginines	25	2.59e-01	-0.131000	4.22e-01
Signaling by NOTCH3	30	2.16e-01	-0.131000	3.71e-01
RHOF GTPase cycle	25	2.60e-01	0.130000	4.23e-01
Metabolism	1253	4.19e-14	-0.130000	1.68e-11
Signaling by ERBB2 TMD/JMD mutants	10	4.78e-01	-0.129000	6.37e-01
Diseases of metabolism	126	1.24e-02	-0.129000	4.66e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity	12	4.39e-01	0.129000	6.02e-01
Trafficking of AMPA receptors	12	4.39e-01	0.129000	6.02e-01
STING mediated induction of host immune responses	10	4.80e-01	0.129000	6.39e-01
Nephrin family interactions	14	4.05e-01	-0.129000	5.73e-01
SARS-CoV Infections	270	3.18e-04	-0.128000	3.27e-03
Negative regulation of NMDA receptor-mediated neuronal transmission	12	4.43e-01	0.128000	6.04e-01
ER Quality Control Compartment (ERQC)	18	3.48e-01	0.128000	5.21e-01
Ca-dependent events	21	3.13e-01	-0.127000	4.87e-01
NGF-stimulated transcription	25	2.71e-01	-0.127000	4.38e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	66	7.57e-02	-0.127000	1.77e-01
Generic Transcription Pathway	826	1.35e-09	-0.126000	1.47e-07
Asparagine N-linked glycosylation	225	1.17e-03	-0.126000	7.75e-03
Mitochondrial translation termination	83	4.75e-02	-0.126000	1.31e-01
BBSome-mediated cargo-targeting to cilium	19	3.42e-01	-0.126000	5.19e-01
Glucagon-type ligand receptors	14	4.16e-01	0.126000	5.82e-01
Mitochondrial translation initiation	84	4.71e-02	-0.125000	1.31e-01
Interferon Signaling	142	1.02e-02	-0.125000	3.96e-02
Cholesterol biosynthesis	22	3.10e-01	-0.125000	4.84e-01
Cell death signalling via NRAGE, NRIF and NADE	45	1.50e-01	-0.124000	2.84e-01
Diseases of carbohydrate metabolism	23	3.03e-01	-0.124000	4.73e-01
Nicotinamide salvaging	11	4.76e-01	0.124000	6.36e-01
tRNA modification in the nucleus and cytosol	34	2.11e-01	-0.124000	3.64e-01
Branched-chain amino acid catabolism	20	3.37e-01	-0.124000	5.14e-01
SUMOylation of transcription factors	13	4.39e-01	-0.124000	6.02e-01
PTEN Regulation	115	2.20e-02	-0.124000	7.40e-02
Metabolism of steroids	86	4.76e-02	-0.124000	1.31e-01
Metal ion SLC transporters	16	3.92e-01	-0.124000	5.60e-01
Meiotic synapsis	25	2.84e-01	-0.124000	4.54e-01
Ribosomal scanning and start codon recognition	47	1.43e-01	-0.123000	2.74e-01
Antigen processing: Ubiquitination & Proteasome degradation	241	1.01e-03	-0.123000	7.23e-03
DAP12 interactions	21	3.28e-01	-0.123000	5.04e-01
Signaling by WNT	177	4.96e-03	-0.123000	2.20e-02
Aquaporin-mediated transport	25	2.89e-01	0.123000	4.59e-01
RNA Polymerase II Transcription	927	5.42e-10	-0.122000	7.24e-08
Translation initiation complex formation	47	1.47e-01	-0.122000	2.81e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	35	2.11e-01	-0.122000	3.64e-01
Negative regulation of MAPK pathway	36	2.06e-01	-0.122000	3.58e-01
Signaling by WNT in cancer	23	3.12e-01	-0.122000	4.86e-01
Beta-catenin independent WNT signaling	106	3.21e-02	-0.121000	9.59e-02
SARS-CoV-2 modulates host translation machinery	39	1.93e-01	-0.121000	3.40e-01
Post-translational protein modification	917	1.26e-09	-0.120000	1.47e-07
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	22	3.29e-01	-0.120000	5.04e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	22	3.29e-01	-0.120000	5.04e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	22	3.29e-01	-0.120000	5.04e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	22	3.29e-01	-0.120000	5.04e-01
Impaired BRCA2 binding to PALB2	22	3.29e-01	-0.120000	5.04e-01
RIP-mediated NFkB activation via ZBP1	14	4.36e-01	-0.120000	6.01e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	61	1.05e-01	-0.120000	2.22e-01
Synthesis of PA	18	3.78e-01	0.120000	5.50e-01
CaM pathway	20	3.53e-01	-0.120000	5.25e-01
Calmodulin induced events	20	3.53e-01	-0.120000	5.25e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	27	2.82e-01	-0.120000	4.52e-01
Pexophagy	11	4.92e-01	-0.120000	6.45e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	35	2.21e-01	0.120000	3.77e-01
MTOR signalling	36	2.15e-01	-0.119000	3.69e-01
Signaling by NOTCH1	51	1.41e-01	-0.119000	2.70e-01
Cellular response to heat stress	80	6.53e-02	-0.119000	1.62e-01
Non-integrin membrane-ECM interactions	14	4.42e-01	0.119000	6.04e-01
Cell junction organization	26	2.96e-01	0.118000	4.66e-01
The phototransduction cascade	18	3.86e-01	0.118000	5.57e-01
Diseases of glycosylation	69	9.01e-02	-0.118000	1.99e-01
Activation of ATR in response to replication stress	36	2.21e-01	-0.118000	3.76e-01
Signaling by NTRK1 (TRKA)	79	7.01e-02	-0.118000	1.67e-01
Transcriptional activation of mitochondrial biogenesis	40	1.99e-01	-0.117000	3.48e-01
Regulation of TP53 Activity through Acetylation	27	2.93e-01	-0.117000	4.66e-01
Adrenaline,noradrenaline inhibits insulin secretion	15	4.33e-01	0.117000	6.00e-01
PKMTs methylate histone lysines	31	2.61e-01	0.117000	4.23e-01
KSRP (KHSRP) binds and destabilizes mRNA	15	4.34e-01	-0.117000	6.00e-01
FCGR3A-mediated IL10 synthesis	22	3.44e-01	-0.117000	5.19e-01
Inactivation of CSF3 (G-CSF) signaling	19	3.80e-01	-0.116000	5.50e-01
TCR signaling	87	6.09e-02	-0.116000	1.53e-01
Ion transport by P-type ATPases	27	2.96e-01	-0.116000	4.66e-01
Signaling by ERBB4	31	2.64e-01	-0.116000	4.28e-01
Extra-nuclear estrogen signaling	49	1.62e-01	-0.116000	2.96e-01
VEGFA-VEGFR2 Pathway	71	9.29e-02	-0.115000	2.03e-01
MAPK family signaling cascades	191	6.11e-03	-0.115000	2.55e-02
RND1 GTPase cycle	29	2.82e-01	-0.115000	4.52e-01
Vesicle-mediated transport	454	2.94e-05	-0.115000	7.37e-04
trans-Golgi Network Vesicle Budding	51	1.55e-01	-0.115000	2.88e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	48	1.68e-01	-0.115000	3.03e-01
MAPK1/MAPK3 signaling	164	1.17e-02	-0.114000	4.47e-02
Collagen biosynthesis and modifying enzymes	19	3.89e-01	0.114000	5.58e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	11	5.15e-01	-0.113000	6.57e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	4.64e-01	-0.113000	6.25e-01
RHOV GTPase cycle	28	3.01e-01	-0.113000	4.70e-01
Metabolism of nitric oxide: NOS3 activation and regulation	12	4.98e-01	-0.113000	6.48e-01
Toll Like Receptor 9 (TLR9) Cascade	70	1.03e-01	-0.113000	2.18e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	29	2.95e-01	-0.112000	4.66e-01
Interferon gamma signaling	55	1.50e-01	-0.112000	2.84e-01
Signaling by PDGF	25	3.33e-01	-0.112000	5.08e-01
G alpha (q) signalling events	78	8.83e-02	0.112000	1.98e-01
Membrane binding and targetting of GAG proteins	12	5.03e-01	-0.112000	6.51e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	12	5.03e-01	-0.112000	6.51e-01
Membrane Trafficking	446	6.95e-05	-0.111000	1.35e-03
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	22	3.69e-01	-0.111000	5.43e-01
Fcgamma receptor (FCGR) dependent phagocytosis	62	1.34e-01	-0.110000	2.65e-01
Signaling by cytosolic FGFR1 fusion mutants	16	4.46e-01	-0.110000	6.06e-01
ECM proteoglycans	13	4.93e-01	0.110000	6.46e-01
G alpha (z) signalling events	25	3.43e-01	0.110000	5.19e-01
Signaling by Hippo	12	5.12e-01	-0.109000	6.55e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	10	5.50e-01	-0.109000	6.84e-01
Toll-like Receptor Cascades	108	5.07e-02	-0.109000	1.36e-01
VEGFR2 mediated vascular permeability	21	3.88e-01	-0.109000	5.58e-01
Interleukin receptor SHC signaling	15	4.69e-01	-0.108000	6.31e-01
Intracellular signaling by second messengers	210	7.26e-03	-0.108000	2.96e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	15	4.70e-01	-0.108000	6.31e-01
Signaling by Activin	12	5.20e-01	0.107000	6.61e-01
Hyaluronan uptake and degradation	10	5.57e-01	-0.107000	6.89e-01
Ras activation upon Ca2+ influx through NMDA receptor	10	5.57e-01	0.107000	6.89e-01
SUMOylation of DNA methylation proteins	14	4.88e-01	0.107000	6.42e-01
EPHB-mediated forward signaling	25	3.55e-01	-0.107000	5.28e-01
Fatty acid metabolism	104	6.03e-02	-0.107000	1.53e-01
Mitochondrial translation elongation	84	9.17e-02	-0.107000	2.02e-01
EGFR downregulation	20	4.09e-01	-0.107000	5.76e-01
RND2 GTPase cycle	34	2.84e-01	-0.106000	4.53e-01
Caspase activation via extrinsic apoptotic signalling pathway	15	4.76e-01	-0.106000	6.36e-01
RHO GTPases activate PAKs	13	5.07e-01	-0.106000	6.53e-01
Listeria monocytogenes entry into host cells	14	4.95e-01	-0.105000	6.47e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	21	4.04e-01	-0.105000	5.73e-01
Signaling by NTRKs	87	9.01e-02	-0.105000	1.99e-01
Signaling by Interleukins	265	3.35e-03	-0.105000	1.67e-02
NOTCH4 Intracellular Domain Regulates Transcription	14	4.96e-01	-0.105000	6.47e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	12	5.29e-01	0.105000	6.67e-01
Signaling by VEGF	73	1.23e-01	-0.105000	2.48e-01
SUMOylation of chromatin organization proteins	49	2.07e-01	-0.104000	3.59e-01
G alpha (i) signalling events	93	8.39e-02	0.104000	1.90e-01
O-linked glycosylation	42	2.44e-01	0.104000	4.07e-01
HDACs deacetylate histones	28	3.43e-01	-0.104000	5.19e-01
Synthesis of very long-chain fatty acyl-CoAs	16	4.73e-01	0.104000	6.34e-01
Unfolded Protein Response (UPR)	76	1.20e-01	-0.103000	2.43e-01
SLC transporter disorders	52	1.99e-01	-0.103000	3.48e-01
Nuclear Envelope Breakdown	49	2.12e-01	-0.103000	3.66e-01
Protein ubiquitination	59	1.72e-01	-0.103000	3.10e-01
Metabolism of fat-soluble vitamins	13	5.21e-01	-0.103000	6.61e-01
Josephin domain DUBs	11	5.56e-01	-0.103000	6.89e-01
Mitophagy	25	3.79e-01	-0.102000	5.50e-01
HSF1 activation	21	4.23e-01	-0.101000	5.91e-01
Signaling by ERBB2 in Cancer	13	5.29e-01	-0.101000	6.67e-01
Assembly and cell surface presentation of NMDA receptors	13	5.29e-01	0.101000	6.67e-01
RAF/MAP kinase cascade	159	2.98e-02	-0.100000	9.15e-02
Fatty acyl-CoA biosynthesis	26	3.77e-01	-0.100000	5.49e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	27	3.70e-01	-0.099800	5.43e-01
Potential therapeutics for SARS	66	1.62e-01	-0.099600	2.96e-01
Cytochrome P450 - arranged by substrate type	14	5.19e-01	0.099500	6.61e-01
Gastrin-CREB signalling pathway via PKC and MAPK	11	5.68e-01	-0.099300	6.98e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	71	1.51e-01	-0.098800	2.84e-01
Toll Like Receptor 2 (TLR2) Cascade	71	1.51e-01	-0.098800	2.84e-01
Toll Like Receptor TLR1:TLR2 Cascade	71	1.51e-01	-0.098800	2.84e-01
Toll Like Receptor TLR6:TLR2 Cascade	71	1.51e-01	-0.098800	2.84e-01
PKA-mediated phosphorylation of CREB	11	5.71e-01	-0.098600	6.99e-01
Other interleukin signaling	15	5.09e-01	-0.098600	6.53e-01
Signaling by Receptor Tyrosine Kinases	293	3.89e-03	-0.098500	1.82e-02
Activation of kainate receptors upon glutamate binding	17	4.82e-01	0.098400	6.40e-01
Adaptive Immune System	481	2.55e-04	-0.098200	2.76e-03
PIP3 activates AKT signaling	185	2.22e-02	-0.097800	7.46e-02
SARS-CoV-1 Infection	46	2.54e-01	-0.097300	4.18e-01
TAK1-dependent IKK and NF-kappa-B activation	18	4.76e-01	-0.097000	6.36e-01
Transcriptional regulation of white adipocyte differentiation	56	2.11e-01	-0.096700	3.64e-01
Intra-Golgi traffic	39	2.96e-01	-0.096700	4.66e-01
Diseases associated with the TLR signaling cascade	17	4.91e-01	-0.096600	6.44e-01
Diseases of Immune System	17	4.91e-01	-0.096600	6.44e-01
Synthesis of PC	22	4.34e-01	-0.096400	6.00e-01
G beta:gamma signalling through PLC beta	13	5.47e-01	0.096400	6.82e-01
Presynaptic function of Kainate receptors	13	5.47e-01	0.096400	6.82e-01
FOXO-mediated transcription	46	2.58e-01	-0.096400	4.22e-01
Macroautophagy	97	1.02e-01	-0.096200	2.17e-01
Formation of the beta-catenin:TCF transactivating complex	25	4.05e-01	-0.096200	5.73e-01
PKA activation	10	6.01e-01	-0.095500	7.27e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	14	5.36e-01	-0.095500	6.71e-01
EPH-ephrin mediated repulsion of cells	25	4.09e-01	-0.095400	5.76e-01
RET signaling	23	4.29e-01	-0.095400	5.96e-01
Pyroptosis	18	4.88e-01	-0.094400	6.42e-01
Cytokine Signaling in Immune system	427	9.13e-04	-0.094300	6.81e-03
Post-translational protein phosphorylation	34	3.45e-01	0.093700	5.19e-01
Mitotic Prophase	75	1.61e-01	-0.093600	2.96e-01
ADP signalling through P2Y purinoceptor 12	13	5.66e-01	0.092000	6.97e-01
Signaling by ERBB2	33	3.61e-01	-0.092000	5.34e-01
Axon guidance	300	6.73e-03	-0.091400	2.77e-02
Cytosolic sensors of pathogen-associated DNA	53	2.51e-01	-0.091200	4.15e-01
Oncogene Induced Senescence	30	3.89e-01	-0.090800	5.58e-01
PI3K/AKT Signaling in Cancer	52	2.59e-01	-0.090600	4.22e-01
Autophagy	106	1.09e-01	-0.090400	2.27e-01
Activation of GABAB receptors	18	5.08e-01	0.090200	6.53e-01
GABA B receptor activation	18	5.08e-01	0.090200	6.53e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	10	6.23e-01	-0.089900	7.47e-01
GPCR downstream signalling	197	3.04e-02	0.089800	9.28e-02
Mucopolysaccharidoses	10	6.24e-01	-0.089600	7.47e-01
G alpha (12/13) signalling events	40	3.28e-01	0.089500	5.04e-01
HDMs demethylate histones	15	5.49e-01	-0.089300	6.84e-01
Signaling by Erythropoietin	19	5.02e-01	-0.089100	6.50e-01
Signaling by BMP	15	5.51e-01	0.089000	6.85e-01
TICAM1, RIP1-mediated IKK complex recruitment	17	5.27e-01	-0.088700	6.67e-01
Glutamate Neurotransmitter Release Cycle	12	5.96e-01	0.088400	7.24e-01
CDC42 GTPase cycle	97	1.34e-01	0.088100	2.65e-01
DARPP-32 events	21	4.86e-01	-0.087900	6.42e-01
PINK1-PRKN Mediated Mitophagy	20	4.99e-01	-0.087300	6.48e-01
Signalling to ERKs	25	4.52e-01	-0.087000	6.13e-01
Chromatin modifying enzymes	158	6.11e-02	-0.086600	1.53e-01
Chromatin organization	158	6.11e-02	-0.086600	1.53e-01
Nervous system development	313	8.89e-03	-0.086500	3.53e-02
Cargo recognition for clathrin-mediated endocytosis	63	2.37e-01	-0.086100	3.97e-01
Synthesis of substrates in N-glycan biosythesis	48	3.06e-01	-0.085400	4.78e-01
Signaling by NODAL	12	6.09e-01	0.085200	7.35e-01
The role of Nef in HIV-1 replication and disease pathogenesis	19	5.21e-01	0.085000	6.61e-01
RAC2 GTPase cycle	56	2.72e-01	0.084800	4.39e-01
RHOH GTPase cycle	29	4.30e-01	0.084600	5.97e-01
Interleukin-15 signaling	11	6.28e-01	-0.084300	7.49e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	23	4.84e-01	0.084200	6.42e-01
Cellular Senescence	106	1.42e-01	-0.082700	2.72e-01
Insulin processing	17	5.56e-01	-0.082500	6.89e-01
GPVI-mediated activation cascade	23	4.96e-01	-0.082100	6.47e-01
RHO GTPases Activate WASPs and WAVEs	29	4.45e-01	-0.082000	6.05e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	24	4.88e-01	0.081700	6.42e-01
Pre-NOTCH Processing in Golgi	16	5.72e-01	-0.081500	6.99e-01
Activation of NMDA receptors and postsynaptic events	44	3.50e-01	-0.081500	5.22e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	32	4.27e-01	-0.081200	5.94e-01
Iron uptake and transport	38	3.89e-01	-0.080800	5.58e-01
HSF1-dependent transactivation	25	4.85e-01	-0.080700	6.42e-01
Extracellular matrix organization	93	1.80e-01	0.080600	3.21e-01
Collagen formation	28	4.60e-01	0.080600	6.21e-01
MAP2K and MAPK activation	25	4.86e-01	0.080500	6.42e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	31	4.40e-01	0.080200	6.02e-01
Integrin signaling	16	5.82e-01	-0.079400	7.09e-01
Platelet Aggregation (Plug Formation)	16	5.82e-01	-0.079400	7.09e-01
Senescence-Associated Secretory Phenotype (SASP)	42	3.74e-01	-0.079400	5.45e-01
Innate Immune System	620	8.63e-04	-0.079300	6.56e-03
Deadenylation of mRNA	23	5.11e-01	-0.079200	6.55e-01
Signaling by GPCR	216	4.68e-02	0.078800	1.31e-01
Inositol phosphate metabolism	30	4.57e-01	-0.078600	6.17e-01
APC-Cdc20 mediated degradation of Nek2A	24	5.06e-01	-0.078400	6.53e-01
Metabolism of steroid hormones	13	6.26e-01	-0.078100	7.48e-01
EPH-Ephrin signaling	55	3.17e-01	-0.078000	4.92e-01
Regulation of signaling by CBL	14	6.13e-01	-0.078000	7.38e-01
Intraflagellar transport	33	4.40e-01	-0.077800	6.02e-01
Mitochondrial calcium ion transport	19	5.58e-01	-0.077600	6.89e-01
Signaling by TGF-beta Receptor Complex	72	2.55e-01	-0.077600	4.19e-01
Apoptotic execution phase	33	4.41e-01	-0.077500	6.03e-01
RAC1 GTPase cycle	110	1.62e-01	0.077400	2.96e-01
NCAM signaling for neurite out-growth	24	5.14e-01	0.077000	6.57e-01
RHOBTB GTPase Cycle	29	4.79e-01	-0.076000	6.37e-01
Cell surface interactions at the vascular wall	56	3.27e-01	0.075900	5.04e-01
Biological oxidations	79	2.46e-01	-0.075600	4.08e-01
Cytochrome c-mediated apoptotic response	11	6.66e-01	-0.075200	7.80e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	26	5.07e-01	-0.075200	6.53e-01
Recycling pathway of L1	15	6.15e-01	-0.074900	7.39e-01
FCERI mediated Ca+2 mobilization	23	5.36e-01	-0.074600	6.71e-01
Developmental Biology	468	6.13e-03	-0.074600	2.55e-02
Class B/2 (Secretin family receptors)	29	4.88e-01	0.074500	6.42e-01
Interleukin-10 signaling	13	6.43e-01	-0.074300	7.61e-01
Inactivation, recovery and regulation of the phototransduction cascade	17	5.98e-01	0.073800	7.25e-01
Clathrin-mediated endocytosis	89	2.33e-01	-0.073200	3.91e-01
Insulin receptor signalling cascade	26	5.19e-01	0.073000	6.61e-01
Sphingolipid metabolism	49	3.79e-01	-0.072700	5.50e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	29	5.00e-01	-0.072400	6.48e-01
Stimuli-sensing channels	39	4.34e-01	0.072400	6.00e-01
mRNA decay by 3’ to 5’ exoribonuclease	14	6.39e-01	-0.072300	7.59e-01
Signaling by Non-Receptor Tyrosine Kinases	36	4.53e-01	-0.072300	6.13e-01
Signaling by PTK6	36	4.53e-01	-0.072300	6.13e-01
MAPK targets/ Nuclear events mediated by MAP kinases	23	5.54e-01	-0.071300	6.88e-01
Signal Transduction	1356	1.91e-05	-0.071100	5.45e-04
Response of EIF2AK1 (HRI) to heme deficiency	14	6.46e-01	-0.070900	7.63e-01
Regulation of FZD by ubiquitination	12	6.71e-01	0.070700	7.83e-01
Sialic acid metabolism	23	5.59e-01	-0.070400	6.89e-01
Fanconi Anemia Pathway	31	4.98e-01	-0.070400	6.48e-01
SUMOylation of transcription cofactors	35	4.72e-01	-0.070200	6.34e-01
G alpha (s) signalling events	48	4.01e-01	0.070200	5.70e-01
Oncogenic MAPK signaling	56	3.68e-01	-0.069500	5.43e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	39	4.53e-01	-0.069400	6.13e-01
Hyaluronan metabolism	11	6.91e-01	-0.069300	8.00e-01
Immune System	1156	1.14e-04	-0.068900	1.75e-03
APC/C:Cdc20 mediated degradation of Cyclin B	22	5.77e-01	-0.068700	7.04e-01
Peptide hormone metabolism	31	5.09e-01	0.068500	6.53e-01
Activated NOTCH1 Transmits Signal to the Nucleus	19	6.10e-01	-0.067700	7.35e-01
Regulation of innate immune responses to cytosolic DNA	12	6.87e-01	0.067100	7.97e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	29	5.33e-01	-0.066900	6.70e-01
Signaling by RAS mutants	29	5.33e-01	-0.066900	6.70e-01
Signaling by moderate kinase activity BRAF mutants	29	5.33e-01	-0.066900	6.70e-01
Signaling downstream of RAS mutants	29	5.33e-01	-0.066900	6.70e-01
Costimulation by the CD28 family	44	4.43e-01	-0.066800	6.04e-01
Signaling by FGFR1 in disease	24	5.73e-01	-0.066600	6.99e-01
Vasopressin regulates renal water homeostasis via Aquaporins	23	5.83e-01	0.066100	7.10e-01
Post NMDA receptor activation events	38	4.82e-01	-0.065900	6.40e-01
GPER1 signaling	25	5.69e-01	0.065900	6.98e-01
RHOQ GTPase cycle	39	4.79e-01	0.065600	6.37e-01
Interleukin-37 signaling	17	6.42e-01	0.065100	7.61e-01
Signaling by Leptin	10	7.24e-01	0.064500	8.25e-01
Attenuation phase	19	6.29e-01	-0.063900	7.49e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	449	2.30e-02	-0.063100	7.66e-02
Nicotinate metabolism	19	6.36e-01	0.062800	7.55e-01
Signal amplification	20	6.30e-01	0.062300	7.49e-01
RAF activation	28	5.70e-01	-0.062100	6.99e-01
Neutrophil degranulation	307	6.32e-02	-0.062000	1.58e-01
Integration of energy metabolism	60	4.12e-01	-0.061300	5.77e-01
Signaling by Rho GTPases	437	2.95e-02	-0.061200	9.10e-02
DCC mediated attractive signaling	11	7.26e-01	0.061100	8.25e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	16	6.73e-01	0.061000	7.83e-01
Transport of small molecules	359	4.86e-02	-0.061000	1.34e-01
L1CAM interactions	41	5.00e-01	-0.061000	6.48e-01
Cytosolic sulfonation of small molecules	10	7.39e-01	-0.060900	8.35e-01
Metabolism of lipids	439	3.06e-02	-0.060700	9.32e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	14	6.96e-01	0.060300	8.04e-01
XBP1(S) activates chaperone genes	42	5.00e-01	-0.060200	6.48e-01
FGFR1 mutant receptor activation	20	6.45e-01	-0.059500	7.63e-01
Cargo concentration in the ER	20	6.48e-01	-0.058900	7.65e-01
Bile acid and bile salt metabolism	15	6.95e-01	0.058400	8.04e-01
GABA receptor activation	19	6.61e-01	0.058100	7.77e-01
A tetrasaccharide linker sequence is required for GAG synthesis	10	7.51e-01	0.057900	8.47e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	19	6.63e-01	-0.057800	7.77e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	19	6.63e-01	-0.057800	7.77e-01
CTLA4 inhibitory signaling	16	6.91e-01	0.057500	8.00e-01
Amino acids regulate mTORC1	42	5.20e-01	-0.057400	6.61e-01
Opioid Signalling	58	4.50e-01	-0.057400	6.12e-01
Transport of vitamins, nucleosides, and related molecules	21	6.49e-01	-0.057300	7.65e-01
Glycosaminoglycan metabolism	64	4.30e-01	-0.057100	5.97e-01
NOTCH3 Intracellular Domain Regulates Transcription	15	7.03e-01	-0.056900	8.08e-01
Nonhomologous End-Joining (NHEJ)	29	5.96e-01	-0.056900	7.24e-01
Signaling by TGFB family members	85	3.66e-01	-0.056800	5.40e-01
Regulation of KIT signaling	10	7.57e-01	0.056600	8.51e-01
Assembly Of The HIV Virion	14	7.15e-01	-0.056300	8.20e-01
Regulation of actin dynamics for phagocytic cup formation	44	5.21e-01	-0.056000	6.61e-01
Netrin-1 signaling	25	6.29e-01	0.055900	7.49e-01
IRE1alpha activates chaperones	43	5.29e-01	-0.055600	6.67e-01
Phase I - Functionalization of compounds	30	6.00e-01	0.055400	7.26e-01
NOD1/2 Signaling Pathway	23	6.46e-01	0.055300	7.63e-01
RHOA GTPase cycle	93	3.59e-01	0.055100	5.32e-01
Heparan sulfate/heparin (HS-GAG) metabolism	22	6.59e-01	-0.054400	7.75e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	27	6.25e-01	-0.054300	7.48e-01
RHOJ GTPase cycle	37	5.72e-01	0.053700	6.99e-01
Ca2+ pathway	40	5.59e-01	-0.053500	6.89e-01
Gap junction trafficking	10	7.71e-01	0.053200	8.61e-01
PPARA activates gene expression	82	4.10e-01	-0.052700	5.77e-01
Gap junction trafficking and regulation	11	7.64e-01	0.052400	8.56e-01
Signaling by SCF-KIT	32	6.10e-01	-0.052100	7.35e-01
Nuclear signaling by ERBB4	16	7.19e-01	-0.052000	8.20e-01
Activation of the pre-replicative complex	30	6.28e-01	-0.051100	7.49e-01
Signaling by BRAF and RAF1 fusions	42	5.68e-01	-0.051000	6.98e-01
Insulin receptor recycling	17	7.17e-01	-0.050800	8.20e-01
Frs2-mediated activation	11	7.72e-01	0.050500	8.61e-01
Transferrin endocytosis and recycling	19	7.04e-01	-0.050300	8.09e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	7.14e-01	-0.049900	8.20e-01
COPII-mediated vesicle transport	51	5.38e-01	-0.049800	6.73e-01
Regulation of lipid metabolism by PPARalpha	84	4.36e-01	-0.049200	6.01e-01
Rab regulation of trafficking	94	4.11e-01	-0.049100	5.77e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	7.34e-01	-0.049000	8.32e-01
Downregulation of TGF-beta receptor signaling	26	6.68e-01	-0.048600	7.80e-01
G-protein beta:gamma signalling	21	7.02e-01	-0.048300	8.08e-01
Effects of PIP2 hydrolysis	19	7.16e-01	0.048200	8.20e-01
IGF1R signaling cascade	23	6.98e-01	-0.046800	8.04e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	23	6.98e-01	-0.046800	8.04e-01
Basigin interactions	14	7.62e-01	0.046800	8.55e-01
RHOBTB2 GTPase cycle	20	7.18e-01	-0.046700	8.20e-01
Telomere Extension By Telomerase	20	7.22e-01	-0.046000	8.23e-01
Transcriptional regulation of granulopoiesis	25	6.92e-01	0.045800	8.00e-01
Cardiac conduction	43	6.04e-01	0.045800	7.29e-01
RHOBTB1 GTPase cycle	18	7.37e-01	-0.045700	8.34e-01
Transcriptional Regulation by VENTX	30	6.68e-01	0.045300	7.80e-01
RAB GEFs exchange GTP for GDP on RABs	64	5.35e-01	0.044900	6.70e-01
Hemostasis	304	1.85e-01	-0.044400	3.30e-01
RHO GTPases Activate NADPH Oxidases	14	7.74e-01	-0.044200	8.61e-01
RHOU GTPase cycle	32	6.67e-01	-0.044000	7.80e-01
Erythropoietin activates RAS	10	8.11e-01	-0.043700	8.89e-01
Platelet homeostasis	49	5.99e-01	-0.043500	7.25e-01
G beta:gamma signalling through CDC42	13	7.87e-01	0.043300	8.70e-01
Sphingolipid de novo biosynthesis	22	7.29e-01	0.042600	8.27e-01
Cell recruitment (pro-inflammatory response)	15	7.78e-01	0.042100	8.63e-01
Purinergic signaling in leishmaniasis infection	15	7.78e-01	0.042100	8.63e-01
Platelet activation, signaling and aggregation	132	4.05e-01	-0.042000	5.73e-01
Metalloprotease DUBs	17	7.65e-01	-0.041900	8.56e-01
Glycerophospholipid biosynthesis	74	5.35e-01	-0.041800	6.70e-01
activated TAK1 mediates p38 MAPK activation	13	7.95e-01	0.041500	8.75e-01
Neuronal System	139	4.04e-01	0.041100	5.73e-01
Transcriptional regulation by RUNX1	137	4.11e-01	-0.040800	5.77e-01
Retinoid metabolism and transport	11	8.15e-01	-0.040700	8.91e-01
Initiation of Nuclear Envelope (NE) Reformation	17	7.73e-01	-0.040500	8.61e-01
Signal transduction by L1	11	8.17e-01	-0.040300	8.91e-01
Neurotransmitter release cycle	20	7.61e-01	-0.039300	8.55e-01
Sensory processing of sound by outer hair cells of the cochlea	18	7.74e-01	-0.039100	8.61e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	45	6.51e-01	-0.039000	7.67e-01
Negative regulation of FLT3	13	8.10e-01	0.038600	8.89e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	23	7.49e-01	0.038500	8.46e-01
IRS-related events triggered by IGF1R	22	7.59e-01	-0.037800	8.53e-01
Glucagon signaling in metabolic regulation	18	7.83e-01	0.037500	8.68e-01
Suppression of phagosomal maturation	12	8.27e-01	0.036500	9.00e-01
FCERI mediated MAPK activation	23	7.66e-01	0.035900	8.56e-01
DAP12 signaling	19	7.88e-01	-0.035600	8.71e-01
Muscle contraction	67	6.15e-01	-0.035600	7.39e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	7.50e-01	0.035500	8.46e-01
Caspase-mediated cleavage of cytoskeletal proteins	10	8.46e-01	0.035500	9.18e-01
Visual phototransduction	34	7.25e-01	0.034900	8.25e-01
G beta:gamma signalling through PI3Kgamma	17	8.06e-01	0.034400	8.85e-01
MAP kinase activation	49	6.81e-01	-0.034000	7.90e-01
Anti-inflammatory response favouring Leishmania parasite infection	54	6.80e-01	-0.032500	7.90e-01
Leishmania parasite growth and survival	54	6.80e-01	-0.032500	7.90e-01
Negative regulation of FGFR1 signaling	18	8.17e-01	0.031500	8.91e-01
Negative regulation of FGFR2 signaling	18	8.17e-01	0.031500	8.91e-01
Negative regulation of FGFR3 signaling	18	8.17e-01	0.031500	8.91e-01
Negative regulation of FGFR4 signaling	18	8.17e-01	0.031500	8.91e-01
Regulation of MECP2 expression and activity	23	7.95e-01	0.031300	8.75e-01
Plasma lipoprotein remodeling	11	8.60e-01	-0.030700	9.28e-01
Termination of O-glycan biosynthesis	10	8.69e-01	0.030100	9.33e-01
rRNA modification in the nucleus and cytosol	49	7.17e-01	-0.030000	8.20e-01
Ephrin signaling	12	8.59e-01	-0.029700	9.27e-01
Chondroitin sulfate/dermatan sulfate metabolism	27	7.90e-01	0.029700	8.71e-01
Pre-NOTCH Expression and Processing	46	7.29e-01	-0.029600	8.27e-01
Regulation of IFNG signaling	13	8.54e-01	0.029600	9.23e-01
Regulation of PTEN gene transcription	48	7.26e-01	-0.029200	8.25e-01
RAB geranylgeranylation	40	7.52e-01	0.028900	8.47e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	33	7.74e-01	0.028900	8.61e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	20	8.27e-01	-0.028300	9.00e-01
Pre-NOTCH Transcription and Translation	31	7.86e-01	-0.028200	8.70e-01
Downregulation of ERBB2:ERBB3 signaling	10	8.78e-01	0.028000	9.37e-01
Regulation of BACH1 activity	11	8.74e-01	-0.027700	9.34e-01
Protein methylation	14	8.66e-01	0.026000	9.31e-01
Synthesis of bile acids and bile salts	13	8.74e-01	0.025500	9.34e-01
Spry regulation of FGF signaling	15	8.65e-01	-0.025400	9.31e-01
Transmission across Chemical Synapses	101	6.69e-01	0.024700	7.81e-01
Phospholipid metabolism	133	6.25e-01	-0.024600	7.48e-01
Zinc transporters	12	8.84e-01	-0.024400	9.39e-01
RHOB GTPase cycle	44	7.93e-01	-0.022900	8.73e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	14	8.83e-01	0.022800	9.39e-01
Late endosomal microautophagy	23	8.51e-01	-0.022700	9.21e-01
Signaling by FGFR4	25	8.46e-01	-0.022400	9.18e-01
Integrin cell surface interactions	25	8.51e-01	0.021800	9.21e-01
Constitutive Signaling by Aberrant PI3K in Cancer	28	8.43e-01	0.021700	9.17e-01
Regulation of TP53 Activity through Methylation	17	8.78e-01	-0.021500	9.37e-01
ROS and RNS production in phagocytes	23	8.63e-01	-0.020800	9.30e-01
Negative regulation of the PI3K/AKT network	56	7.90e-01	-0.020600	8.71e-01
Inflammasomes	16	8.87e-01	-0.020400	9.41e-01
Apoptotic cleavage of cellular proteins	25	8.63e-01	-0.019900	9.30e-01
Prolonged ERK activation events	13	9.02e-01	0.019800	9.51e-01
Detoxification of Reactive Oxygen Species	23	8.70e-01	0.019600	9.33e-01
RHO GTPases Activate ROCKs	13	9.07e-01	-0.018700	9.52e-01
Metabolic disorders of biological oxidation enzymes	14	9.06e-01	-0.018300	9.52e-01
Calnexin/calreticulin cycle	23	8.80e-01	-0.018100	9.37e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	19	8.91e-01	-0.018100	9.44e-01
Phosphorylation of the APC/C	18	8.94e-01	-0.018100	9.45e-01
Carboxyterminal post-translational modifications of tubulin	24	8.79e-01	-0.018000	9.37e-01
Processing of SMDT1	13	9.11e-01	-0.017800	9.54e-01
NR1H2 and NR1H3-mediated signaling	27	8.73e-01	0.017800	9.34e-01
Negative regulation of MET activity	16	9.02e-01	0.017800	9.51e-01
Infection with Mycobacterium tuberculosis	22	8.86e-01	0.017600	9.41e-01
CD209 (DC-SIGN) signaling	15	9.07e-01	-0.017400	9.52e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	9.07e-01	-0.016800	9.52e-01
Synthesis of PIPs at the Golgi membrane	12	9.21e-01	-0.016500	9.58e-01
Leishmania infection	112	7.64e-01	-0.016400	8.56e-01
Regulation of RUNX1 Expression and Activity	17	9.07e-01	0.016300	9.52e-01
Cell-Cell communication	48	8.46e-01	0.016200	9.18e-01
FOXO-mediated transcription of cell cycle genes	13	9.20e-01	-0.016000	9.58e-01
Synthesis of PIPs at the early endosome membrane	12	9.25e-01	0.015800	9.59e-01
SLC-mediated transmembrane transport	105	7.87e-01	-0.015300	8.70e-01
Neurexins and neuroligins	21	9.04e-01	-0.015200	9.52e-01
Regulation of insulin secretion	40	8.68e-01	0.015200	9.33e-01
Myogenesis	13	9.25e-01	-0.015100	9.59e-01
Nuclear events stimulated by ALK signaling in cancer	14	9.28e-01	0.014000	9.61e-01
FLT3 Signaling	32	8.93e-01	-0.013700	9.44e-01
Synthesis of PIPs at the plasma membrane	36	8.88e-01	-0.013500	9.41e-01
The NLRP3 inflammasome	12	9.39e-01	0.012700	9.66e-01
Syndecan interactions	10	9.45e-01	-0.012500	9.69e-01
RUNX2 regulates osteoblast differentiation	13	9.38e-01	-0.012400	9.66e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	50	8.79e-01	-0.012400	9.37e-01
Interconversion of nucleotide di- and triphosphates	25	9.15e-01	-0.012300	9.55e-01
Ion channel transport	80	8.53e-01	-0.012000	9.23e-01
RND3 GTPase cycle	29	9.11e-01	-0.012000	9.54e-01
PI3K Cascade	19	9.30e-01	0.011600	9.62e-01
Sensory processing of sound	27	9.17e-01	-0.011500	9.55e-01
Sensory processing of sound by inner hair cells of the cochlea	27	9.17e-01	-0.011500	9.55e-01
Growth hormone receptor signaling	17	9.36e-01	0.011300	9.66e-01
NRAGE signals death through JNK	30	9.16e-01	0.011200	9.55e-01
Downregulation of ERBB2 signaling	17	9.37e-01	-0.011100	9.66e-01
Transport of bile salts and organic acids, metal ions and amine compounds	34	9.15e-01	0.010600	9.55e-01
Lysosome Vesicle Biogenesis	24	9.31e-01	-0.010200	9.62e-01
PI Metabolism	60	8.92e-01	-0.010100	9.44e-01
O-linked glycosylation of mucins	26	9.29e-01	0.010000	9.62e-01
Signaling by RAF1 mutants	25	9.36e-01	-0.009240	9.66e-01
Response of Mtb to phagocytosis	20	9.44e-01	-0.009050	9.68e-01
Signaling by high-kinase activity BRAF mutants	22	9.42e-01	-0.008940	9.67e-01
Uptake and actions of bacterial toxins	18	9.49e-01	0.008630	9.71e-01
Signaling by Insulin receptor	42	9.24e-01	0.008540	9.59e-01
Interleukin-2 family signaling	28	9.38e-01	0.008460	9.66e-01
Dopamine Neurotransmitter Release Cycle	12	9.60e-01	0.008440	9.78e-01
RUNX2 regulates bone development	18	9.52e-01	0.008260	9.73e-01
Signaling by FGFR1	28	9.41e-01	-0.008140	9.66e-01
Amino acid transport across the plasma membrane	16	9.59e-01	0.007420	9.78e-01
Protein-protein interactions at synapses	33	9.49e-01	0.006460	9.71e-01
mTORC1-mediated signalling	21	9.61e-01	0.006240	9.78e-01
Degradation of the extracellular matrix	35	9.55e-01	0.005530	9.75e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	9.69e-01	-0.005220	9.83e-01
Signaling by FGFR3	26	9.64e-01	-0.005160	9.81e-01
Amyloid fiber formation	27	9.67e-01	-0.004630	9.83e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	15	9.80e-01	-0.003710	9.90e-01
RHO GTPase cycle	294	9.15e-01	0.003630	9.55e-01
IRS-mediated signalling	21	9.78e-01	0.003410	9.89e-01
FCGR3A-mediated phagocytosis	42	9.71e-01	0.003240	9.83e-01
Leishmania phagocytosis	42	9.71e-01	0.003240	9.83e-01
Parasite infection	42	9.71e-01	0.003240	9.83e-01
Maturation of nucleoprotein	11	9.85e-01	-0.003210	9.91e-01
Oxidative Stress Induced Senescence	55	9.71e-01	0.002880	9.83e-01
ADORA2B mediated anti-inflammatory cytokines production	33	9.82e-01	-0.002300	9.91e-01
Sensory Perception	68	9.76e-01	0.002150	9.87e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	38	9.83e-01	0.001940	9.91e-01
TGF-beta receptor signaling activates SMADs	39	9.85e-01	0.001710	9.91e-01
E2F mediated regulation of DNA replication	19	9.91e-01	-0.001550	9.94e-01
RHOC GTPase cycle	49	9.87e-01	0.001360	9.91e-01
Interleukin-17 signaling	52	9.87e-01	-0.001340	9.91e-01
Neurotransmitter receptors and postsynaptic signal transmission	77	9.84e-01	0.001330	9.91e-01
Budding and maturation of HIV virion	24	9.92e-01	-0.001140	9.95e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	11	9.96e-01	0.000803	9.97e-01
TP53 Regulates Transcription of Cell Death Genes	31	9.95e-01	0.000608	9.97e-01
Transcriptional Regulation by MECP2	31	9.97e-01	0.000358	9.97e-01

---

Detailed Gene set reports

Signaling by FGFR2 IIIa TM

Signaling by FGFR2 IIIa TM

	971
set	Signaling by FGFR2 IIIa TM
setSize	15
pANOVA	9.84e-05
s.dist	-0.581
p.adjustANOVA	0.00169

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-11114.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
POLR2C	-7787.0
POLR2H	-7744.0
POLR2G	-3915.0
POLR2K	-2872.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-11114.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
POLR2C	-7787.0
POLR2H	-7744.0
POLR2G	-3915.0
POLR2K	-2872.0

---

TNFs bind their physiological receptors

TNFs bind their physiological receptors

	1066
set	TNFs bind their physiological receptors
setSize	10
pANOVA	0.00935
s.dist	0.475
p.adjustANOVA	0.0366

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TNFRSF25	566.0
EDARADD	0.5
TNFSF14	0.5
CD27	-1338.0
TNFRSF1B	-1498.0
LTA	-1742.0
TNFSF13	-1822.5
TNFSF9	-3475.0
TNFRSF1A	-6875.0
TNFSF13B	-7586.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TNFRSF25	566.0
EDARADD	0.5
TNFSF14	0.5
CD27	-1338.0
TNFRSF1B	-1498.0
LTA	-1742.0
TNFSF13	-1822.5
TNFSF9	-3475.0
TNFRSF1A	-6875.0
TNFSF13B	-7586.0

---

Inhibition of DNA recombination at telomere

Inhibition of DNA recombination at telomere

	448
set	Inhibition of DNA recombination at telomere
setSize	18
pANOVA	0.000678
s.dist	-0.463
p.adjustANOVA	0.00559

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
TERF2IP	-10500.5
POLR2F	-10467.5
POLR2L	-10380.5
DAXX	-10076.0
TINF2	-9186.0
POLR2E	-8601.0
POLR2I	-8371.5
POLR2C	-7787.0
POLR2H	-7744.0
ACD	-6775.5
TERF2	-6009.0
H2AFX	-4953.0
TERF1	-4423.0
POLR2G	-3915.0
POLR2K	-2872.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
TERF2IP	-10500.5
POLR2F	-10467.5
POLR2L	-10380.5
DAXX	-10076.0
TINF2	-9186.0
POLR2E	-8601.0
POLR2I	-8371.5
POLR2C	-7787.0
POLR2H	-7744.0
ACD	-6775.5
TERF2	-6009.0
H2AFX	-4953.0
TERF1	-4423.0
POLR2G	-3915.0
POLR2K	-2872.0

---

FGFR2 mutant receptor activation

FGFR2 mutant receptor activation

	309
set	FGFR2 mutant receptor activation
setSize	17
pANOVA	0.00117
s.dist	-0.455
p.adjustANOVA	0.00775

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-11114.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
POLR2C	-7787.0
POLR2H	-7744.0
FGF9	-4554.0
POLR2G	-3915.0
POLR2K	-2872.0
FGF8	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-11114.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
POLR2C	-7787.0
POLR2H	-7744.0
FGF9	-4554.0
POLR2G	-3915.0
POLR2K	-2872.0
FGF8	0.5

---

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

	1072
set	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
setSize	12
pANOVA	0.0089
s.dist	-0.436
p.adjustANOVA	0.0353

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1B	-10926.0
E2F7	-10184.0
CCNE1	-10174.0
CCNA2	-9888.0
TP53	-9885.5
E2F8	-9811.0
PCBP4	-9678.0
E2F1	-7525.0
CCNE2	-5648.0
CDK2	-5295.0
ARID3A	-5076.0
CDKN1A	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1B	-10926.0
E2F7	-10184.0
CCNE1	-10174.0
CCNA2	-9888.0
TP53	-9885.5
E2F8	-9811.0
PCBP4	-9678.0
E2F1	-7525.0
CCNE2	-5648.0
CDK2	-5295.0
ARID3A	-5076.0
CDKN1A	0.5

---

TNFR1-induced proapoptotic signaling

TNFR1-induced proapoptotic signaling

	1064
set	TNFR1-induced proapoptotic signaling
setSize	12
pANOVA	0.00903
s.dist	-0.435
p.adjustANOVA	0.0356

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TNFAIP3	-10705.0
USP4	-10459.0
CYLD	-9698.0
FADD	-9600.0
TRADD	-9428.5
USP2	-7516.0
USP21	-7350.0
TRAF2	-7293.0
TNFRSF1A	-6875.0
OTUD7B	-6731.0
CASP8	-4236.0
TNF	-4137.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TNFAIP3	-10705.0
USP4	-10459.0
CYLD	-9698.0
FADD	-9600.0
TRADD	-9428.5
USP2	-7516.0
USP21	-7350.0
TRAF2	-7293.0
TNFRSF1A	-6875.0
OTUD7B	-6731.0
CASP8	-4236.0
TNF	-4137.0

---

mRNA Capping

mRNA Capping

	1181
set	mRNA Capping
setSize	26
pANOVA	0.000206
s.dist	-0.421
p.adjustANOVA	0.00239

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-11114.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
POLR2F	-10467.5
RNMT	-10466.0
POLR2L	-10380.5
SUPT5H	-10348.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
CCNH	-7205.0
GTF2H5	-6121.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-11114.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
POLR2F	-10467.5
RNMT	-10466.0
POLR2L	-10380.5
SUPT5H	-10348.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
CCNH	-7205.0
GTF2H5	-6121.5
POLR2G	-3915.0
CDK7	-3477.0
POLR2K	-2872.0
MNAT1	-1528.0
ERCC3	-1496.0
RNGTT	-771.0

---

Signaling by FGFR2 in disease

Signaling by FGFR2 in disease

	972
set	Signaling by FGFR2 in disease
setSize	24
pANOVA	0.000366
s.dist	-0.42
p.adjustANOVA	0.00352

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-11114.5
GRB2	-10839.0
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
PIK3R1	-9732.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
POLR2C	-7787.0
POLR2H	-7744.0
PIK3CA	-6756.0
PLCG1	-6564.0
KRAS	-5891.0
HRAS	-5455.0
FRS2	-5433.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-11114.5
GRB2	-10839.0
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
PIK3R1	-9732.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
POLR2C	-7787.0
POLR2H	-7744.0
PIK3CA	-6756.0
PLCG1	-6564.0
KRAS	-5891.0
HRAS	-5455.0
FRS2	-5433.0
FGF9	-4554.0
POLR2G	-3915.0
POLR2K	-2872.0
FGF8	0.5

---

Competing endogenous RNAs (ceRNAs) regulate PTEN translation

Competing endogenous RNAs (ceRNAs) regulate PTEN translation

	162
set	Competing endogenous RNAs (ceRNAs) regulate PTEN translation
setSize	10
pANOVA	0.0214
s.dist	0.42
p.adjustANOVA	0.0726

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AGO3	0.5
AGO1	0.5
MIR19A	0.5
MIR17	-1762.0
TNRC6B	-2401.0
MOV10	-2500.0
AGO2	-2845.0
CNOT6L	-4728.0
TNRC6A	-5956.0
VAPA	-6852.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AGO3	0.5
AGO1	0.5
MIR19A	0.5
MIR17	-1762.0
TNRC6B	-2401.0
MOV10	-2500.0
AGO2	-2845.0
CNOT6L	-4728.0
TNRC6A	-5956.0
VAPA	-6852.0

---

Purine salvage

Purine salvage

	745
set	Purine salvage
setSize	11
pANOVA	0.0176
s.dist	-0.413
p.adjustANOVA	0.0627

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GMPR2	-10971.5
ADK	-10538.0
AMPD2	-10260.0
APRT	-9472.0
ADAL	-9312.5
DCK	-7773.0
AMPD3	-6759.0
PNP	-6639.0
DGUOK	-5513.0
GMPR	-5145.0
ADA	-2358.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GMPR2	-10971.5
ADK	-10538.0
AMPD2	-10260.0
APRT	-9472.0
ADAL	-9312.5
DCK	-7773.0
AMPD3	-6759.0
PNP	-6639.0
DGUOK	-5513.0
GMPR	-5145.0
ADA	-2358.0

---

Abortive elongation of HIV-1 transcript in the absence of Tat

Abortive elongation of HIV-1 transcript in the absence of Tat

	24
set	Abortive elongation of HIV-1 transcript in the absence of Tat
setSize	22
pANOVA	0.000932
s.dist	-0.408
p.adjustANOVA	0.00691

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-11114.5
POLR2D	-10830.0
SUPT4H1	-10827.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
SUPT5H	-10348.0
CTDP1	-9760.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
POLR2C	-7787.0
POLR2H	-7744.0
POLR2G	-3915.0
NELFA	-3818.0
NELFB	-3347.0
POLR2K	-2872.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-11114.5
POLR2D	-10830.0
SUPT4H1	-10827.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
SUPT5H	-10348.0
CTDP1	-9760.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
POLR2C	-7787.0
POLR2H	-7744.0
POLR2G	-3915.0
NELFA	-3818.0
NELFB	-3347.0
POLR2K	-2872.0
NELFCD	0.5
NELFE	0.5

---

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

	908
set	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize	10
pANOVA	0.0274
s.dist	-0.403
p.adjustANOVA	0.0863

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-11114.5
SNRPG	-10153.0
LSM10	-9096.0
LSM11	-8890.0
NCBP2	-8252.0
ZNF473	-8201.5
SNRPD3	-8084.0
SLBP	-7252.0
SNRPE	-4548.0
SNRPB	-829.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-11114.5
SNRPG	-10153.0
LSM10	-9096.0
LSM11	-8890.0
NCBP2	-8252.0
ZNF473	-8201.5
SNRPD3	-8084.0
SLBP	-7252.0
SNRPE	-4548.0
SNRPB	-829.0

---

Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects

Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects

	21
set	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
setSize	16
pANOVA	0.00549
s.dist	-0.401
p.adjustANOVA	0.0236

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1B	-10926.0
CCND1	-10727.0
CCND2	-10382.0
CCND3	-10179.0
CCNE1	-10174.0
RB1	-9349.0
CDK6	-9142.0
E2F3	-8327.0
E2F1	-7525.0
CDK4	-7376.0
E2F2	-6440.0
TFDP1	-6131.0
CCNE2	-5648.0
CDK2	-5295.0
TFDP2	-4443.0
CDKN1A	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1B	-10926.0
CCND1	-10727.0
CCND2	-10382.0
CCND3	-10179.0
CCNE1	-10174.0
RB1	-9349.0
CDK6	-9142.0
E2F3	-8327.0
E2F1	-7525.0
CDK4	-7376.0
E2F2	-6440.0
TFDP1	-6131.0
CCNE2	-5648.0
CDK2	-5295.0
TFDP2	-4443.0
CDKN1A	0.5

---

Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)

Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)

	214
set	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
setSize	16
pANOVA	0.00549
s.dist	-0.401
p.adjustANOVA	0.0236

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1B	-10926.0
CCND1	-10727.0
CCND2	-10382.0
CCND3	-10179.0
CCNE1	-10174.0
RB1	-9349.0
CDK6	-9142.0
E2F3	-8327.0
E2F1	-7525.0
CDK4	-7376.0
E2F2	-6440.0
TFDP1	-6131.0
CCNE2	-5648.0
CDK2	-5295.0
TFDP2	-4443.0
CDKN1A	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1B	-10926.0
CCND1	-10727.0
CCND2	-10382.0
CCND3	-10179.0
CCNE1	-10174.0
RB1	-9349.0
CDK6	-9142.0
E2F3	-8327.0
E2F1	-7525.0
CDK4	-7376.0
E2F2	-6440.0
TFDP1	-6131.0
CCNE2	-5648.0
CDK2	-5295.0
TFDP2	-4443.0
CDKN1A	0.5

---

Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)

	1042
set	Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize	10
pANOVA	0.0288
s.dist	0.399
p.adjustANOVA	0.0896

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GGT1	591
DPEP2	-1249
LTA4H	-1314
ALOX5AP	-1446
LTC4S	-2396
CYP4F22	-2423
PTGR1	-2444
MAPKAPK2	-3310
ALOX5	-5585
ABCC1	-8712

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GGT1	591
DPEP2	-1249
LTA4H	-1314
ALOX5AP	-1446
LTC4S	-2396
CYP4F22	-2423
PTGR1	-2444
MAPKAPK2	-3310
ALOX5	-5585
ABCC1	-8712

---

Assembly of the ORC complex at the origin of replication

Assembly of the ORC complex at the origin of replication

	66
set	Assembly of the ORC complex at the origin of replication
setSize	10
pANOVA	0.0293
s.dist	0.398
p.adjustANOVA	0.0908

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ORC1	727.0
ORC3	0.5
KPNA6	-854.0
ORC5	-1355.0
ORC6	-1833.0
ORC4	-2085.5
ORC2	-3423.0
H2AFX	-4953.0
KPNB1	-7061.0
KPNA1	-7530.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ORC1	727.0
ORC3	0.5
KPNA6	-854.0
ORC5	-1355.0
ORC6	-1833.0
ORC4	-2085.5
ORC2	-3423.0
H2AFX	-4953.0
KPNB1	-7061.0
KPNA1	-7530.0

---

Endosomal/Vacuolar pathway

Endosomal/Vacuolar pathway

	287
set	Endosomal/Vacuolar pathway
setSize	10
pANOVA	0.0297
s.dist	-0.397
p.adjustANOVA	0.0914

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HLA-E	-11221
HLA-C	-11127
HLA-B	-10804
HLA-H	-10398
HLA-F	-9491
LNPEP	-8485
HLA-A	-6825
CTSL	-4314
CTSV	-2858
B2M	-551

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HLA-E	-11221
HLA-C	-11127
HLA-B	-10804
HLA-H	-10398
HLA-F	-9491
LNPEP	-8485
HLA-A	-6825
CTSL	-4314
CTSV	-2858
B2M	-551

---

RNA Pol II CTD phosphorylation and interaction with CE

RNA Pol II CTD phosphorylation and interaction with CE

	786
set	RNA Pol II CTD phosphorylation and interaction with CE
setSize	24
pANOVA	0.000847
s.dist	-0.394
p.adjustANOVA	0.00656

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
POLR2F	-10467.5
RNMT	-10466.0
POLR2L	-10380.5
SUPT5H	-10348.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
CCNH	-7205.0
GTF2H5	-6121.5
POLR2G	-3915.0
CDK7	-3477.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
POLR2F	-10467.5
RNMT	-10466.0
POLR2L	-10380.5
SUPT5H	-10348.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
CCNH	-7205.0
GTF2H5	-6121.5
POLR2G	-3915.0
CDK7	-3477.0
POLR2K	-2872.0
MNAT1	-1528.0
ERCC3	-1496.0
RNGTT	-771.0

---

RNA Pol II CTD phosphorylation and interaction with CE during HIV infection

RNA Pol II CTD phosphorylation and interaction with CE during HIV infection

	787
set	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
setSize	24
pANOVA	0.000847
s.dist	-0.394
p.adjustANOVA	0.00656

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
POLR2F	-10467.5
RNMT	-10466.0
POLR2L	-10380.5
SUPT5H	-10348.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
CCNH	-7205.0
GTF2H5	-6121.5
POLR2G	-3915.0
CDK7	-3477.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
POLR2F	-10467.5
RNMT	-10466.0
POLR2L	-10380.5
SUPT5H	-10348.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
CCNH	-7205.0
GTF2H5	-6121.5
POLR2G	-3915.0
CDK7	-3477.0
POLR2K	-2872.0
MNAT1	-1528.0
ERCC3	-1496.0
RNGTT	-771.0

---

FGFR2 alternative splicing

FGFR2 alternative splicing

	308
set	FGFR2 alternative splicing
setSize	22
pANOVA	0.00157
s.dist	-0.389
p.adjustANOVA	0.00921

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-11114.5
HNRNPF	-11102.0
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
POLR2C	-7787.0
POLR2H	-7744.0
TIA1	-7651.0
TIAL1	-6974.0
POLR2G	-3915.0
ESRP2	-3327.0
POLR2K	-2872.0
HNRNPH1	-2782.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-11114.5
HNRNPF	-11102.0
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
POLR2C	-7787.0
POLR2H	-7744.0
TIA1	-7651.0
TIAL1	-6974.0
POLR2G	-3915.0
ESRP2	-3327.0
POLR2K	-2872.0
HNRNPH1	-2782.0
PTBP1	-2566.0
HNRNPM	-1277.0

---

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

	1178
set	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize	10
pANOVA	0.0393
s.dist	-0.376
p.adjustANOVA	0.113

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ELOVL1	-10920.0
FADS2	-10853.0
FADS1	-10280.0
ACOX1	-8873.0
ACAA1	-8609.0
SCP2	-7055.0
ELOVL5	-6979.0
ACOT8	-5223.5
ACSL1	-3458.0
HSD17B4	-2577.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ELOVL1	-10920.0
FADS2	-10853.0
FADS1	-10280.0
ACOX1	-8873.0
ACAA1	-8609.0
SCP2	-7055.0
ELOVL5	-6979.0
ACOT8	-5223.5
ACSL1	-3458.0
HSD17B4	-2577.0

---

alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism

	1179
set	alpha-linolenic acid (ALA) metabolism
setSize	10
pANOVA	0.0393
s.dist	-0.376
p.adjustANOVA	0.113

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ELOVL1	-10920.0
FADS2	-10853.0
FADS1	-10280.0
ACOX1	-8873.0
ACAA1	-8609.0
SCP2	-7055.0
ELOVL5	-6979.0
ACOT8	-5223.5
ACSL1	-3458.0
HSD17B4	-2577.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ELOVL1	-10920.0
FADS2	-10853.0
FADS1	-10280.0
ACOX1	-8873.0
ACAA1	-8609.0
SCP2	-7055.0
ELOVL5	-6979.0
ACOT8	-5223.5
ACSL1	-3458.0
HSD17B4	-2577.0

---

Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs

	731
set	Processing of Intronless Pre-mRNAs
setSize	15
pANOVA	0.0125
s.dist	-0.373
p.adjustANOVA	0.0468

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-11114.5
CPSF4	-10263.5
CLP1	-10254.0
SYMPK	-10049.0
CPSF2	-10040.5
PAPOLA	-9422.0
CPSF1	-8812.0
FIP1L1	-8322.0
NCBP2	-8252.0
CPSF3	-6846.5
CSTF1	-5237.5
WDR33	-5196.0
NUDT21	-4334.5
CPSF6	-2510.0
PABPN1	-1239.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-11114.5
CPSF4	-10263.5
CLP1	-10254.0
SYMPK	-10049.0
CPSF2	-10040.5
PAPOLA	-9422.0
CPSF1	-8812.0
FIP1L1	-8322.0
NCBP2	-8252.0
CPSF3	-6846.5
CSTF1	-5237.5
WDR33	-5196.0
NUDT21	-4334.5
CPSF6	-2510.0
PABPN1	-1239.0

---

SUMOylation of immune response proteins

SUMOylation of immune response proteins

	922
set	SUMOylation of immune response proteins
setSize	10
pANOVA	0.0443
s.dist	-0.367
p.adjustANOVA	0.126

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NFKB2	-10948
UBE2I	-9641
NFKBIA	-9113
PIAS4	-7982
RELA	-7688
PIAS3	-7677
IKBKE	-6700
SUMO1	-6129
TOPORS	-5898
SUMO3	-2508

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NFKB2	-10948
UBE2I	-9641
NFKBIA	-9113
PIAS4	-7982
RELA	-7688
PIAS3	-7677
IKBKE	-6700
SUMO1	-6129
TOPORS	-5898
SUMO3	-2508

---

Other semaphorin interactions

Other semaphorin interactions

	664
set	Other semaphorin interactions
setSize	10
pANOVA	0.0454
s.dist	0.365
p.adjustANOVA	0.128

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SEMA4D	620.0
TYROBP	0.5
SEMA4A	0.5
PTPRC	0.5
PLXNA2	-711.0
CD72	-878.0
PLXNC1	-4978.0
PLXND1	-6751.0
ITGA1	-7915.5
SEMA7A	-9712.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SEMA4D	620.0
TYROBP	0.5
SEMA4A	0.5
PTPRC	0.5
PLXNA2	-711.0
CD72	-878.0
PLXNC1	-4978.0
PLXND1	-6751.0
ITGA1	-7915.5
SEMA7A	-9712.0

---

Signaling by ERBB2 ECD mutants

Signaling by ERBB2 ECD mutants

	960
set	Signaling by ERBB2 ECD mutants
setSize	10
pANOVA	0.0465
s.dist	-0.364
p.adjustANOVA	0.131

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GRB2	-10839.0
HSP90AA1	-10443.0
PIK3R1	-9732.0
CDC37	-9273.5
PIK3CA	-6756.0
SHC1	-6692.5
PLCG1	-6564.0
KRAS	-5891.0
HRAS	-5455.0
ERBB2	-2414.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GRB2	-10839.0
HSP90AA1	-10443.0
PIK3R1	-9732.0
CDC37	-9273.5
PIK3CA	-6756.0
SHC1	-6692.5
PLCG1	-6564.0
KRAS	-5891.0
HRAS	-5455.0
ERBB2	-2414.0

---

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

	51
set	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
setSize	26
pANOVA	0.00158
s.dist	-0.358
p.adjustANOVA	0.00921

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HLA-E	-11221.0
TAPBP	-11220.0
TAP1	-11215.0
HLA-C	-11127.0
SEC24A	-10906.0
SEC23A	-10888.0
HLA-B	-10804.0
HLA-H	-10398.0
PDIA3	-9865.5
SEC24B	-9588.0
ERAP1	-9538.0
HLA-F	-9491.0
CALR	-9246.0
SEC13	-8862.0
SEC31A	-8445.0
BECN1	-7977.0
SAR1B	-7849.0
TAP2	-6868.0
HLA-A	-6825.0
CANX	-3277.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HLA-E	-11221.0
TAPBP	-11220.0
TAP1	-11215.0
HLA-C	-11127.0
SEC24A	-10906.0
SEC23A	-10888.0
HLA-B	-10804.0
HLA-H	-10398.0
PDIA3	-9865.5
SEC24B	-9588.0
ERAP1	-9538.0
HLA-F	-9491.0
CALR	-9246.0
SEC13	-8862.0
SEC31A	-8445.0
BECN1	-7977.0
SAR1B	-7849.0
TAP2	-6868.0
HLA-A	-6825.0
CANX	-3277.0
SEC24D	-2308.0
PIK3R4	-1874.0
SEC24C	-1281.0
B2M	-551.0
ATG14	0.5
ERAP2	0.5

---

Disorders of Developmental Biology

Disorders of Developmental Biology

	248
set	Disorders of Developmental Biology
setSize	10
pANOVA	0.05
s.dist	-0.358
p.adjustANOVA	0.135

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKACA	-10561
HDAC3	-10075
SIN3A	-9334
NCOR1	-9314
CALM1	-8409
HDAC1	-7321
CAMK4	-6998
TBL1XR1	-6891
GPS2	-3196
NCOR2	-1627

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKACA	-10561
HDAC3	-10075
SIN3A	-9334
NCOR1	-9314
CALM1	-8409
HDAC1	-7321
CAMK4	-6998
TBL1XR1	-6891
GPS2	-3196
NCOR2	-1627

---

Disorders of Nervous System Development

Disorders of Nervous System Development

	249
set	Disorders of Nervous System Development
setSize	10
pANOVA	0.05
s.dist	-0.358
p.adjustANOVA	0.135

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKACA	-10561
HDAC3	-10075
SIN3A	-9334
NCOR1	-9314
CALM1	-8409
HDAC1	-7321
CAMK4	-6998
TBL1XR1	-6891
GPS2	-3196
NCOR2	-1627

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKACA	-10561
HDAC3	-10075
SIN3A	-9334
NCOR1	-9314
CALM1	-8409
HDAC1	-7321
CAMK4	-6998
TBL1XR1	-6891
GPS2	-3196
NCOR2	-1627

---

Loss of function of MECP2 in Rett syndrome

Loss of function of MECP2 in Rett syndrome

	515
set	Loss of function of MECP2 in Rett syndrome
setSize	10
pANOVA	0.05
s.dist	-0.358
p.adjustANOVA	0.135

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKACA	-10561
HDAC3	-10075
SIN3A	-9334
NCOR1	-9314
CALM1	-8409
HDAC1	-7321
CAMK4	-6998
TBL1XR1	-6891
GPS2	-3196
NCOR2	-1627

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKACA	-10561
HDAC3	-10075
SIN3A	-9334
NCOR1	-9314
CALM1	-8409
HDAC1	-7321
CAMK4	-6998
TBL1XR1	-6891
GPS2	-3196
NCOR2	-1627

---

Pervasive developmental disorders

Pervasive developmental disorders

	695
set	Pervasive developmental disorders
setSize	10
pANOVA	0.05
s.dist	-0.358
p.adjustANOVA	0.135

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKACA	-10561
HDAC3	-10075
SIN3A	-9334
NCOR1	-9314
CALM1	-8409
HDAC1	-7321
CAMK4	-6998
TBL1XR1	-6891
GPS2	-3196
NCOR2	-1627

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKACA	-10561
HDAC3	-10075
SIN3A	-9334
NCOR1	-9314
CALM1	-8409
HDAC1	-7321
CAMK4	-6998
TBL1XR1	-6891
GPS2	-3196
NCOR2	-1627

---

Degradation of cysteine and homocysteine

Degradation of cysteine and homocysteine

	223
set	Degradation of cysteine and homocysteine
setSize	10
pANOVA	0.0503
s.dist	-0.357
p.adjustANOVA	0.136

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GOT2	-10070.0
SQRDL	-9997.0
CSAD	-9926.5
ADO	-9825.0
TSTD1	-9043.0
ETHE1	-6588.0
CTH	-5391.0
TXN2	-4750.0
MPST	-4050.5
TST	-4050.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GOT2	-10070.0
SQRDL	-9997.0
CSAD	-9926.5
ADO	-9825.0
TSTD1	-9043.0
ETHE1	-6588.0
CTH	-5391.0
TXN2	-4750.0
MPST	-4050.5
TST	-4050.5

---

HIV elongation arrest and recovery

HIV elongation arrest and recovery

	411
set	HIV elongation arrest and recovery
setSize	27
pANOVA	0.00133
s.dist	-0.357
p.adjustANOVA	0.00838

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2D	-10830.0
SUPT4H1	-10827.0
CCNK	-10778.5
CDK9	-10699.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
SUPT5H	-10348.0
CTDP1	-9760.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
CCNT1	-8065.0
POLR2C	-7787.0
POLR2H	-7744.0
SSRP1	-6661.0
TCEA1	-5199.0
SUPT16H	-4348.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2D	-10830.0
SUPT4H1	-10827.0
CCNK	-10778.5
CDK9	-10699.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
SUPT5H	-10348.0
CTDP1	-9760.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
CCNT1	-8065.0
POLR2C	-7787.0
POLR2H	-7744.0
SSRP1	-6661.0
TCEA1	-5199.0
SUPT16H	-4348.0
POLR2G	-3915.0
NELFA	-3818.0
ELL	-3699.0
NELFB	-3347.0
POLR2K	-2872.0
NELFCD	0.5
NELFE	0.5

---

Pausing and recovery of HIV elongation

Pausing and recovery of HIV elongation

	688
set	Pausing and recovery of HIV elongation
setSize	27
pANOVA	0.00133
s.dist	-0.357
p.adjustANOVA	0.00838

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2D	-10830.0
SUPT4H1	-10827.0
CCNK	-10778.5
CDK9	-10699.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
SUPT5H	-10348.0
CTDP1	-9760.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
CCNT1	-8065.0
POLR2C	-7787.0
POLR2H	-7744.0
SSRP1	-6661.0
TCEA1	-5199.0
SUPT16H	-4348.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2D	-10830.0
SUPT4H1	-10827.0
CCNK	-10778.5
CDK9	-10699.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
SUPT5H	-10348.0
CTDP1	-9760.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
CCNT1	-8065.0
POLR2C	-7787.0
POLR2H	-7744.0
SSRP1	-6661.0
TCEA1	-5199.0
SUPT16H	-4348.0
POLR2G	-3915.0
NELFA	-3818.0
ELL	-3699.0
NELFB	-3347.0
POLR2K	-2872.0
NELFCD	0.5
NELFE	0.5

---

HIV Transcription Initiation

HIV Transcription Initiation

	410
set	HIV Transcription Initiation
setSize	39
pANOVA	0.000126
s.dist	-0.355
p.adjustANOVA	0.00175

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
TAF12	-7698.0
CCNH	-7205.0
TAF5	-7185.0
TAF15	-6771.0
GTF2E2	-6696.0
GTF2A1	-6642.0
TAF2	-6349.0
GTF2H5	-6121.5
TAF4B	-6038.0
GTF2A2	-5706.0
TAF7	-5597.0
POLR2G	-3915.0
TAF13	-3572.0
CDK7	-3477.0
TAF4	-3206.0
POLR2K	-2872.0
MNAT1	-1528.0
ERCC3	-1496.0
GTF2B	-527.0

---

RNA Polymerase II HIV Promoter Escape

RNA Polymerase II HIV Promoter Escape

	793
set	RNA Polymerase II HIV Promoter Escape
setSize	39
pANOVA	0.000126
s.dist	-0.355
p.adjustANOVA	0.00175

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
TAF12	-7698.0
CCNH	-7205.0
TAF5	-7185.0
TAF15	-6771.0
GTF2E2	-6696.0
GTF2A1	-6642.0
TAF2	-6349.0
GTF2H5	-6121.5
TAF4B	-6038.0
GTF2A2	-5706.0
TAF7	-5597.0
POLR2G	-3915.0
TAF13	-3572.0
CDK7	-3477.0
TAF4	-3206.0
POLR2K	-2872.0
MNAT1	-1528.0
ERCC3	-1496.0
GTF2B	-527.0

---

RNA Polymerase II Promoter Escape

RNA Polymerase II Promoter Escape

	795
set	RNA Polymerase II Promoter Escape
setSize	39
pANOVA	0.000126
s.dist	-0.355
p.adjustANOVA	0.00175

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
TAF12	-7698.0
CCNH	-7205.0
TAF5	-7185.0
TAF15	-6771.0
GTF2E2	-6696.0
GTF2A1	-6642.0
TAF2	-6349.0
GTF2H5	-6121.5
TAF4B	-6038.0
GTF2A2	-5706.0
TAF7	-5597.0
POLR2G	-3915.0
TAF13	-3572.0
CDK7	-3477.0
TAF4	-3206.0
POLR2K	-2872.0
MNAT1	-1528.0
ERCC3	-1496.0
GTF2B	-527.0

---

RNA Polymerase II Transcription Initiation

RNA Polymerase II Transcription Initiation

	798
set	RNA Polymerase II Transcription Initiation
setSize	39
pANOVA	0.000126
s.dist	-0.355
p.adjustANOVA	0.00175

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
TAF12	-7698.0
CCNH	-7205.0
TAF5	-7185.0
TAF15	-6771.0
GTF2E2	-6696.0
GTF2A1	-6642.0
TAF2	-6349.0
GTF2H5	-6121.5
TAF4B	-6038.0
GTF2A2	-5706.0
TAF7	-5597.0
POLR2G	-3915.0
TAF13	-3572.0
CDK7	-3477.0
TAF4	-3206.0
POLR2K	-2872.0
MNAT1	-1528.0
ERCC3	-1496.0
GTF2B	-527.0

---

RNA Polymerase II Transcription Initiation And Promoter Clearance

RNA Polymerase II Transcription Initiation And Promoter Clearance

	799
set	RNA Polymerase II Transcription Initiation And Promoter Clearance
setSize	39
pANOVA	0.000126
s.dist	-0.355
p.adjustANOVA	0.00175

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
TAF12	-7698.0
CCNH	-7205.0
TAF5	-7185.0
TAF15	-6771.0
GTF2E2	-6696.0
GTF2A1	-6642.0
TAF2	-6349.0
GTF2H5	-6121.5
TAF4B	-6038.0
GTF2A2	-5706.0
TAF7	-5597.0
POLR2G	-3915.0
TAF13	-3572.0
CDK7	-3477.0
TAF4	-3206.0
POLR2K	-2872.0
MNAT1	-1528.0
ERCC3	-1496.0
GTF2B	-527.0

---

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

	800
set	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
setSize	39
pANOVA	0.000126
s.dist	-0.355
p.adjustANOVA	0.00175

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAF9	-11152.5
GTF2H3	-10911.5
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
TAF6	-10475.5
POLR2F	-10467.5
TBP	-10407.5
TAF11	-10399.5
POLR2L	-10380.5
TAF10	-9445.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
TAF3	-8320.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
TAF12	-7698.0
CCNH	-7205.0
TAF5	-7185.0
TAF15	-6771.0
GTF2E2	-6696.0
GTF2A1	-6642.0
TAF2	-6349.0
GTF2H5	-6121.5
TAF4B	-6038.0
GTF2A2	-5706.0
TAF7	-5597.0
POLR2G	-3915.0
TAF13	-3572.0
CDK7	-3477.0
TAF4	-3206.0
POLR2K	-2872.0
MNAT1	-1528.0
ERCC3	-1496.0
GTF2B	-527.0

---

Processing of Capped Intronless Pre-mRNA

Processing of Capped Intronless Pre-mRNA

	729
set	Processing of Capped Intronless Pre-mRNA
setSize	23
pANOVA	0.00331
s.dist	-0.354
p.adjustANOVA	0.0165

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-11114.5
CPSF4	-10263.5
CLP1	-10254.0
SNRPG	-10153.0
SYMPK	-10049.0
CPSF2	-10040.5
PAPOLA	-9422.0
LSM10	-9096.0
LSM11	-8890.0
CPSF1	-8812.0
FIP1L1	-8322.0
NCBP2	-8252.0
ZNF473	-8201.5
SNRPD3	-8084.0
SLBP	-7252.0
CPSF3	-6846.5
CSTF1	-5237.5
WDR33	-5196.0
SNRPE	-4548.0
NUDT21	-4334.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-11114.5
CPSF4	-10263.5
CLP1	-10254.0
SNRPG	-10153.0
SYMPK	-10049.0
CPSF2	-10040.5
PAPOLA	-9422.0
LSM10	-9096.0
LSM11	-8890.0
CPSF1	-8812.0
FIP1L1	-8322.0
NCBP2	-8252.0
ZNF473	-8201.5
SNRPD3	-8084.0
SLBP	-7252.0
CPSF3	-6846.5
CSTF1	-5237.5
WDR33	-5196.0
SNRPE	-4548.0
NUDT21	-4334.5
CPSF6	-2510.0
PABPN1	-1239.0
SNRPB	-829.0

---

Purine ribonucleoside monophosphate biosynthesis

Purine ribonucleoside monophosphate biosynthesis

	744
set	Purine ribonucleoside monophosphate biosynthesis
setSize	10
pANOVA	0.0539
s.dist	-0.352
p.adjustANOVA	0.142

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATIC	-10117.0
GMPS	-8921.0
IMPDH1	-8633.0
ADSL	-8486.0
ADSS	-8008.0
IMPDH2	-6946.0
PFAS	-6504.0
PAICS	-5498.5
PPAT	-5498.5
ADSSL1	-4759.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATIC	-10117.0
GMPS	-8921.0
IMPDH1	-8633.0
ADSL	-8486.0
ADSS	-8008.0
IMPDH2	-6946.0
PFAS	-6504.0
PAICS	-5498.5
PPAT	-5498.5
ADSSL1	-4759.0

---

PIWI-interacting RNA (piRNA) biogenesis

PIWI-interacting RNA (piRNA) biogenesis

	677
set	PIWI-interacting RNA (piRNA) biogenesis
setSize	16
pANOVA	0.015
s.dist	-0.351
p.adjustANOVA	0.0544

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
POLR2F	-10467.5
HSP90AA1	-10443.0
POLR2L	-10380.5
POLR2E	-8601.0
POLR2I	-8371.5
POLR2C	-7787.0
POLR2H	-7744.0
HENMT1	-7103.0
TDRKH	-4349.0
POLR2G	-3915.0
POLR2K	-2872.0
MYBL1	-2799.0
PLD6	-554.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2D	-10830.0
POLR2A	-10548.0
POLR2B	-10534.0
POLR2F	-10467.5
HSP90AA1	-10443.0
POLR2L	-10380.5
POLR2E	-8601.0
POLR2I	-8371.5
POLR2C	-7787.0
POLR2H	-7744.0
HENMT1	-7103.0
TDRKH	-4349.0
POLR2G	-3915.0
POLR2K	-2872.0
MYBL1	-2799.0
PLD6	-554.0

---

Cross-presentation of soluble exogenous antigens (endosomes)

Cross-presentation of soluble exogenous antigens (endosomes)

	176
set	Cross-presentation of soluble exogenous antigens (endosomes)
setSize	38
pANOVA	0.00018
s.dist	-0.351
p.adjustANOVA	0.00223

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB8	-11223.0
PSMB9	-11203.0
PSMB3	-11086.0
PSME1	-10729.0
PSMC5	-10693.5
PSMA2	-10497.5
PSMB1	-10407.5
PSMD11	-10335.0
PSMB6	-10197.0
PSME2	-10020.5
PSMD4	-9966.0
PSMA7	-9928.0
PSMD3	-9715.0
PSMD8	-9686.0
PSMC3	-9590.0
PSMA5	-9370.0
PSMB5	-9224.0
PSME3	-8631.0
PSMD1	-8165.0
PSMC1	-8119.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB8	-11223.0
PSMB9	-11203.0
PSMB3	-11086.0
PSME1	-10729.0
PSMC5	-10693.5
PSMA2	-10497.5
PSMB1	-10407.5
PSMD11	-10335.0
PSMB6	-10197.0
PSME2	-10020.5
PSMD4	-9966.0
PSMA7	-9928.0
PSMD3	-9715.0
PSMD8	-9686.0
PSMC3	-9590.0
PSMA5	-9370.0
PSMB5	-9224.0
PSME3	-8631.0
PSMD1	-8165.0
PSMC1	-8119.0
PSMD14	-7970.0
PSMA1	-7634.0
PSMD9	-7543.0
MRC2	-7471.0
PSMD13	-7448.5
PSMB10	-6395.0
PSMA6	-6270.0
PSMA3	-5259.0
PSMD6	-4860.0
PSMD12	-4833.0
PSMD2	-4667.0
PSMD7	-4232.0
PSME4	-3622.0
PSMC4	-1218.0
PSMC6	-827.0
PSMF1	0.5
PSMB2	0.5
PSMB7	599.0

---

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

	1154
set	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
setSize	44
pANOVA	5.62e-05
s.dist	-0.351
p.adjustANOVA	0.00111

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB8	-11223.0
PSMB9	-11203.0
PSMB3	-11086.0
PSME1	-10729.0
PSMC5	-10693.5
PSMA2	-10497.5
PSMB1	-10407.5
PSMD11	-10335.0
PSMB6	-10197.0
PSME2	-10020.5
PSMD4	-9966.0
PSMA7	-9928.0
CHEK2	-9804.5
PSMD3	-9715.0
PSMD8	-9686.0
CHEK1	-9651.0
PSMC3	-9590.0
PSMA5	-9370.0
PSMB5	-9224.0
CDC25A	-9120.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB8	-11223.0
PSMB9	-11203.0
PSMB3	-11086.0
PSME1	-10729.0
PSMC5	-10693.5
PSMA2	-10497.5
PSMB1	-10407.5
PSMD11	-10335.0
PSMB6	-10197.0
PSME2	-10020.5
PSMD4	-9966.0
PSMA7	-9928.0
CHEK2	-9804.5
PSMD3	-9715.0
PSMD8	-9686.0
CHEK1	-9651.0
PSMC3	-9590.0
PSMA5	-9370.0
PSMB5	-9224.0
CDC25A	-9120.0
PSME3	-8631.0
PSMD1	-8165.0
PSMC1	-8119.0
UBA52	-8098.0
PSMD14	-7970.0
PSMA1	-7634.0
PSMD9	-7543.0
PSMD13	-7448.5
PSMB10	-6395.0
PSMA6	-6270.0
UBB	-5720.0
PSMA3	-5259.0
RPS27A	-4937.0
PSMD6	-4860.0
PSMD12	-4833.0
PSMD2	-4667.0
PSMD7	-4232.0
UBC	-4015.0
PSME4	-3622.0
PSMC4	-1218.0
PSMC6	-827.0
PSMF1	0.5
PSMB2	0.5
PSMB7	599.0

---

p53-Independent DNA Damage Response

p53-Independent DNA Damage Response

	1190
set	p53-Independent DNA Damage Response
setSize	44
pANOVA	5.62e-05
s.dist	-0.351
p.adjustANOVA	0.00111

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB8	-11223.0
PSMB9	-11203.0
PSMB3	-11086.0
PSME1	-10729.0
PSMC5	-10693.5
PSMA2	-10497.5
PSMB1	-10407.5
PSMD11	-10335.0
PSMB6	-10197.0
PSME2	-10020.5
PSMD4	-9966.0
PSMA7	-9928.0
CHEK2	-9804.5
PSMD3	-9715.0
PSMD8	-9686.0
CHEK1	-9651.0
PSMC3	-9590.0
PSMA5	-9370.0
PSMB5	-9224.0
CDC25A	-9120.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB8	-11223.0
PSMB9	-11203.0
PSMB3	-11086.0
PSME1	-10729.0
PSMC5	-10693.5
PSMA2	-10497.5
PSMB1	-10407.5
PSMD11	-10335.0
PSMB6	-10197.0
PSME2	-10020.5
PSMD4	-9966.0
PSMA7	-9928.0
CHEK2	-9804.5
PSMD3	-9715.0
PSMD8	-9686.0
CHEK1	-9651.0
PSMC3	-9590.0
PSMA5	-9370.0
PSMB5	-9224.0
CDC25A	-9120.0
PSME3	-8631.0
PSMD1	-8165.0
PSMC1	-8119.0
UBA52	-8098.0
PSMD14	-7970.0
PSMA1	-7634.0
PSMD9	-7543.0
PSMD13	-7448.5
PSMB10	-6395.0
PSMA6	-6270.0
UBB	-5720.0
PSMA3	-5259.0
RPS27A	-4937.0
PSMD6	-4860.0
PSMD12	-4833.0
PSMD2	-4667.0
PSMD7	-4232.0
UBC	-4015.0
PSME4	-3622.0
PSMC4	-1218.0
PSMC6	-827.0
PSMF1	0.5
PSMB2	0.5
PSMB7	599.0

---

p53-Independent G1/S DNA damage checkpoint

p53-Independent G1/S DNA damage checkpoint

	1191
set	p53-Independent G1/S DNA damage checkpoint
setSize	44
pANOVA	5.62e-05
s.dist	-0.351
p.adjustANOVA	0.00111

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMB8	-11223.0
PSMB9	-11203.0
PSMB3	-11086.0
PSME1	-10729.0
PSMC5	-10693.5
PSMA2	-10497.5
PSMB1	-10407.5
PSMD11	-10335.0
PSMB6	-10197.0
PSME2	-10020.5
PSMD4	-9966.0
PSMA7	-9928.0
CHEK2	-9804.5
PSMD3	-9715.0
PSMD8	-9686.0
CHEK1	-9651.0
PSMC3	-9590.0
PSMA5	-9370.0
PSMB5	-9224.0
CDC25A	-9120.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMB8	-11223.0
PSMB9	-11203.0
PSMB3	-11086.0
PSME1	-10729.0
PSMC5	-10693.5
PSMA2	-10497.5
PSMB1	-10407.5
PSMD11	-10335.0
PSMB6	-10197.0
PSME2	-10020.5
PSMD4	-9966.0
PSMA7	-9928.0
CHEK2	-9804.5
PSMD3	-9715.0
PSMD8	-9686.0
CHEK1	-9651.0
PSMC3	-9590.0
PSMA5	-9370.0
PSMB5	-9224.0
CDC25A	-9120.0
PSME3	-8631.0
PSMD1	-8165.0
PSMC1	-8119.0
UBA52	-8098.0
PSMD14	-7970.0
PSMA1	-7634.0
PSMD9	-7543.0
PSMD13	-7448.5
PSMB10	-6395.0
PSMA6	-6270.0
UBB	-5720.0
PSMA3	-5259.0
RPS27A	-4937.0
PSMD6	-4860.0
PSMD12	-4833.0
PSMD2	-4667.0
PSMD7	-4232.0
UBC	-4015.0
PSME4	-3622.0
PSMC4	-1218.0
PSMC6	-827.0
PSMF1	0.5
PSMB2	0.5
PSMB7	599.0

---

Viral Messenger RNA Synthesis

Viral Messenger RNA Synthesis

	1166
set	Viral Messenger RNA Synthesis
setSize	41
pANOVA	0.000108
s.dist	-0.35
p.adjustANOVA	0.00175

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP153	-10890.0
POLR2D	-10830.0
NUP37	-10665.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
NUP93	-10171.0
NUP155	-9979.0
NUP62	-9969.5
NUP160	-9771.0
NUP188	-9757.5
NUP88	-9734.5
NUP50	-9654.0
SEC13	-8862.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NUP85	-8226.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP153	-10890.0
POLR2D	-10830.0
NUP37	-10665.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
NUP93	-10171.0
NUP155	-9979.0
NUP62	-9969.5
NUP160	-9771.0
NUP188	-9757.5
NUP88	-9734.5
NUP50	-9654.0
SEC13	-8862.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NUP85	-8226.0
POM121C	-8104.0
POLR2C	-7787.0
POLR2H	-7744.0
NUP98	-7707.0
RANBP2	-6481.0
NUP214	-6458.0
NUP210	-6452.0
NUP133	-6383.0
RAE1	-5815.0
POM121	-5784.0
TPR	-5774.0
NUP43	-5450.0
NUP54	-4573.0
POLR2G	-3915.0
AAAS	-3203.0
POLR2K	-2872.0
SEH1L	-2692.0
NUP107	-2551.0
NUP205	-2499.0
NUP35	-1130.0
NDC1	0.5

---

Striated Muscle Contraction

Striated Muscle Contraction

	1033
set	Striated Muscle Contraction
setSize	10
pANOVA	0.0569
s.dist	-0.348
p.adjustANOVA	0.147

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACTN3	-10907.0
TMOD2	-10761.0
TPM3	-10131.0
TPM4	-8970.0
TMOD3	-8081.0
TNNC1	-6399.5
TPM1	-5932.0
TPM2	-5694.0
MYBPC2	-3652.0
VIM	-2579.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACTN3	-10907.0
TMOD2	-10761.0
TPM3	-10131.0
TPM4	-8970.0
TMOD3	-8081.0
TNNC1	-6399.5
TPM1	-5932.0
TPM2	-5694.0
MYBPC2	-3652.0
VIM	-2579.0

---

Formation of the Early Elongation Complex

Formation of the Early Elongation Complex

	328
set	Formation of the Early Elongation Complex
setSize	30
pANOVA	0.00126
s.dist	-0.34
p.adjustANOVA	0.00815

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-11114.5
GTF2H3	-10911.5
POLR2D	-10830.0
SUPT4H1	-10827.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
SUPT5H	-10348.0
CTDP1	-9760.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
CCNH	-7205.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-11114.5
GTF2H3	-10911.5
POLR2D	-10830.0
SUPT4H1	-10827.0
POLR2A	-10548.0
POLR2B	-10534.0
GTF2H4	-10510.0
GTF2F2	-10486.0
POLR2F	-10467.5
POLR2L	-10380.5
SUPT5H	-10348.0
CTDP1	-9760.0
GTF2F1	-8706.0
POLR2E	-8601.0
POLR2I	-8371.5
NCBP2	-8252.0
ERCC2	-7919.0
POLR2C	-7787.0
POLR2H	-7744.0
CCNH	-7205.0
GTF2H5	-6121.5
POLR2G	-3915.0
NELFA	-3818.0
CDK7	-3477.0
NELFB	-3347.0
POLR2K	-2872.0
MNAT1	-1528.0
ERCC3	-1496.0
NELFCD	0.5
NELFE	0.5

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report