date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##           metric
## TAP1   -15.94472
## TRIM27 -21.24357
## PSMB9  -15.55163
## PSMB8  -12.49077
## PPT2   -13.27388
## CSNK2B -16.13823
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2546
num_genes_in_profile 12012
duplicated_genes_present 0
num_profile_genes_in_sets 5835
num_profile_genes_not_in_sets 6177

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2546
num_genesets_excluded 1344
num_genesets_included 1202

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Signaling by FGFR2 IIIa TM 15 8.17e-05 -0.587 0.00164
TNFs bind their physiological receptors 10 8.67e-03 0.479 0.03930
FGFR2 mutant receptor activation 17 6.30e-04 -0.479 0.00682
Inhibition of DNA recombination at telomere 18 4.97e-04 -0.474 0.00563
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 1.88e-02 -0.429 0.06800
Signaling by FGFR2 in disease 24 3.00e-04 -0.426 0.00413
Synthesis of glycosylphosphatidylinositol (GPI) 14 5.89e-03 -0.425 0.02920
Processing of Intronless Pre-mRNAs 15 4.45e-03 -0.424 0.02410
Endosomal/Vacuolar pathway 10 2.10e-02 -0.421 0.07310
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 2.45e-02 0.411 0.08350
FGFR2 alternative splicing 22 8.57e-04 -0.411 0.00818
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 2.61e-02 -0.406 0.08710
alpha-linolenic acid (ALA) metabolism 10 2.61e-02 -0.406 0.08710
Metabolism of folate and pterines 11 2.09e-02 -0.402 0.07310
Purine ribonucleoside monophosphate biosynthesis 10 2.84e-02 -0.400 0.09190
mRNA Capping 26 4.47e-04 -0.398 0.00526
Purine salvage 11 2.30e-02 -0.396 0.07850
Generation of second messenger molecules 15 8.25e-03 0.394 0.03820
Processing of Capped Intronless Pre-mRNA 23 1.15e-03 -0.392 0.01010
Abortive elongation of HIV-1 transcript in the absence of Tat 22 1.61e-03 -0.388 0.01260
Defects in vitamin and cofactor metabolism 16 7.16e-03 -0.388 0.03400
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 26 7.26e-04 -0.383 0.00740
PIWI-interacting RNA (piRNA) biogenesis 16 9.71e-03 -0.373 0.04260
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 2.52e-02 -0.373 0.08560
Striated Muscle Contraction 10 4.28e-02 -0.370 0.12500
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 2.10e-02 -0.370 0.07310
Gluconeogenesis 24 1.83e-03 -0.367 0.01340
TNFR1-induced proapoptotic signaling 12 2.77e-02 -0.367 0.09030
RNA Pol II CTD phosphorylation and interaction with CE 24 2.15e-03 -0.362 0.01470
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 24 2.15e-03 -0.362 0.01470
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 1.26e-02 -0.360 0.05090
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 1.26e-02 -0.360 0.05090
Interleukin-6 signaling 10 5.03e-02 -0.357 0.14000
Elevation of cytosolic Ca2+ levels 10 5.61e-02 -0.349 0.15200
Other semaphorin interactions 10 5.69e-02 0.348 0.15300
Association of TriC/CCT with target proteins during biosynthesis 29 1.20e-03 -0.348 0.01030
Assembly of the ORC complex at the origin of replication 10 5.94e-02 0.344 0.15800
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 19 9.55e-03 -0.343 0.04250
Interleukin-35 Signalling 11 4.90e-02 -0.343 0.13800
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 6.08e-02 0.342 0.16000
TRAF6 mediated NF-kB activation 19 9.79e-03 -0.342 0.04280
Binding and Uptake of Ligands by Scavenger Receptors 10 6.12e-02 -0.342 0.16000
TRAF6 mediated IRF7 activation 16 1.93e-02 -0.338 0.06890
tRNA Aminoacylation 23 5.30e-03 -0.336 0.02720
HIV Transcription Initiation 39 2.85e-04 -0.336 0.00403
RNA Polymerase II HIV Promoter Escape 39 2.85e-04 -0.336 0.00403
RNA Polymerase II Promoter Escape 39 2.85e-04 -0.336 0.00403
RNA Polymerase II Transcription Initiation 39 2.85e-04 -0.336 0.00403
RNA Polymerase II Transcription Initiation And Promoter Clearance 39 2.85e-04 -0.336 0.00403
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 39 2.85e-04 -0.336 0.00403


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Signaling by FGFR2 IIIa TM 15 8.17e-05 -0.587000 1.64e-03
TNFs bind their physiological receptors 10 8.67e-03 0.479000 3.93e-02
FGFR2 mutant receptor activation 17 6.30e-04 -0.479000 6.82e-03
Inhibition of DNA recombination at telomere 18 4.97e-04 -0.474000 5.63e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 1.88e-02 -0.429000 6.80e-02
Signaling by FGFR2 in disease 24 3.00e-04 -0.426000 4.13e-03
Synthesis of glycosylphosphatidylinositol (GPI) 14 5.89e-03 -0.425000 2.92e-02
Processing of Intronless Pre-mRNAs 15 4.45e-03 -0.424000 2.41e-02
Endosomal/Vacuolar pathway 10 2.10e-02 -0.421000 7.31e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 2.45e-02 0.411000 8.35e-02
FGFR2 alternative splicing 22 8.57e-04 -0.411000 8.18e-03
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 2.61e-02 -0.406000 8.71e-02
alpha-linolenic acid (ALA) metabolism 10 2.61e-02 -0.406000 8.71e-02
Metabolism of folate and pterines 11 2.09e-02 -0.402000 7.31e-02
Purine ribonucleoside monophosphate biosynthesis 10 2.84e-02 -0.400000 9.19e-02
mRNA Capping 26 4.47e-04 -0.398000 5.26e-03
Purine salvage 11 2.30e-02 -0.396000 7.85e-02
Generation of second messenger molecules 15 8.25e-03 0.394000 3.82e-02
Processing of Capped Intronless Pre-mRNA 23 1.15e-03 -0.392000 1.01e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 22 1.61e-03 -0.388000 1.26e-02
Defects in vitamin and cofactor metabolism 16 7.16e-03 -0.388000 3.40e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 26 7.26e-04 -0.383000 7.40e-03
PIWI-interacting RNA (piRNA) biogenesis 16 9.71e-03 -0.373000 4.26e-02
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 2.52e-02 -0.373000 8.56e-02
Striated Muscle Contraction 10 4.28e-02 -0.370000 1.25e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 2.10e-02 -0.370000 7.31e-02
Gluconeogenesis 24 1.83e-03 -0.367000 1.34e-02
TNFR1-induced proapoptotic signaling 12 2.77e-02 -0.367000 9.03e-02
RNA Pol II CTD phosphorylation and interaction with CE 24 2.15e-03 -0.362000 1.47e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 24 2.15e-03 -0.362000 1.47e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 1.26e-02 -0.360000 5.09e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 1.26e-02 -0.360000 5.09e-02
Interleukin-6 signaling 10 5.03e-02 -0.357000 1.40e-01
Elevation of cytosolic Ca2+ levels 10 5.61e-02 -0.349000 1.52e-01
Other semaphorin interactions 10 5.69e-02 0.348000 1.53e-01
Association of TriC/CCT with target proteins during biosynthesis 29 1.20e-03 -0.348000 1.03e-02
Assembly of the ORC complex at the origin of replication 10 5.94e-02 0.344000 1.58e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 19 9.55e-03 -0.343000 4.25e-02
Interleukin-35 Signalling 11 4.90e-02 -0.343000 1.38e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 6.08e-02 0.342000 1.60e-01
TRAF6 mediated NF-kB activation 19 9.79e-03 -0.342000 4.28e-02
Binding and Uptake of Ligands by Scavenger Receptors 10 6.12e-02 -0.342000 1.60e-01
TRAF6 mediated IRF7 activation 16 1.93e-02 -0.338000 6.89e-02
tRNA Aminoacylation 23 5.30e-03 -0.336000 2.72e-02
HIV Transcription Initiation 39 2.85e-04 -0.336000 4.03e-03
RNA Polymerase II HIV Promoter Escape 39 2.85e-04 -0.336000 4.03e-03
RNA Polymerase II Promoter Escape 39 2.85e-04 -0.336000 4.03e-03
RNA Polymerase II Transcription Initiation 39 2.85e-04 -0.336000 4.03e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance 39 2.85e-04 -0.336000 4.03e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 39 2.85e-04 -0.336000 4.03e-03
Disorders of Developmental Biology 10 6.76e-02 -0.334000 1.71e-01
Disorders of Nervous System Development 10 6.76e-02 -0.334000 1.71e-01
Loss of function of MECP2 in Rett syndrome 10 6.76e-02 -0.334000 1.71e-01
Pervasive developmental disorders 10 6.76e-02 -0.334000 1.71e-01
Peptide ligand-binding receptors 20 1.04e-02 0.331000 4.47e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 4.71e-02 -0.331000 1.34e-01
Voltage gated Potassium channels 13 3.91e-02 0.330000 1.17e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 4.18e-02 -0.326000 1.22e-01
SUMOylation of immune response proteins 10 7.59e-02 -0.324000 1.86e-01
Prefoldin mediated transfer of substrate to CCT/TriC 17 2.09e-02 -0.324000 7.31e-02
Viral Messenger RNA Synthesis 41 3.53e-04 -0.323000 4.66e-03
Signaling by NTRK2 (TRKB) 15 3.07e-02 -0.322000 9.83e-02
Mitochondrial tRNA aminoacylation 18 1.86e-02 -0.320000 6.78e-02
Formation of tubulin folding intermediates by CCT/TriC 14 3.83e-02 -0.320000 1.15e-01
Purine catabolism 10 8.02e-02 -0.319000 1.94e-01
MicroRNA (miRNA) biogenesis 21 1.16e-02 -0.318000 4.77e-02
HIV elongation arrest and recovery 27 4.31e-03 -0.317000 2.37e-02
Pausing and recovery of HIV elongation 27 4.31e-03 -0.317000 2.37e-02
Signaling by PDGFR in disease 15 3.34e-02 -0.317000 1.05e-01
Nucleotide salvage 18 2.03e-02 -0.316000 7.15e-02
Transport of Mature mRNA Derived from an Intronless Transcript 40 6.72e-04 -0.311000 6.98e-03
Loss of Nlp from mitotic centrosomes 56 5.79e-05 -0.311000 1.26e-03
Loss of proteins required for interphase microtubule organization from the centrosome 56 5.79e-05 -0.311000 1.26e-03
Formation of the Early Elongation Complex 30 3.24e-03 -0.311000 1.93e-02
Formation of the HIV-1 Early Elongation Complex 30 3.24e-03 -0.311000 1.93e-02
Triglyceride catabolism 11 7.48e-02 -0.310000 1.85e-01
Glycogen synthesis 11 7.49e-02 -0.310000 1.85e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 41 6.04e-04 -0.310000 6.66e-03
Signaling by ERBB2 ECD mutants 10 9.03e-02 -0.309000 2.09e-01
Cross-presentation of soluble exogenous antigens (endosomes) 38 9.74e-04 -0.309000 8.75e-03
Interleukin-7 signaling 14 4.56e-02 -0.309000 1.31e-01
Deposition of new CENPA-containing nucleosomes at the centromere 23 1.05e-02 -0.308000 4.47e-02
Nucleosome assembly 23 1.05e-02 -0.308000 4.47e-02
TRAF3-dependent IRF activation pathway 14 4.69e-02 -0.307000 1.34e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 44 4.44e-04 -0.306000 5.26e-03
p53-Independent DNA Damage Response 44 4.44e-04 -0.306000 5.26e-03
p53-Independent G1/S DNA damage checkpoint 44 4.44e-04 -0.306000 5.26e-03
Mismatch Repair 13 5.69e-02 -0.305000 1.53e-01
Vitamin B5 (pantothenate) metabolism 11 8.07e-02 -0.304000 1.95e-01
Degradation of GLI2 by the proteasome 50 2.02e-04 -0.304000 3.38e-03
GLI3 is processed to GLI3R by the proteasome 50 2.02e-04 -0.304000 3.38e-03
Role of phospholipids in phagocytosis 16 3.57e-02 -0.303000 1.10e-01
Anchoring of the basal body to the plasma membrane 80 3.02e-06 -0.302000 1.21e-04
RAF-independent MAPK1/3 activation 20 1.94e-02 -0.302000 6.90e-02
Degradation of cysteine and homocysteine 10 9.91e-02 -0.301000 2.25e-01
Pausing and recovery of Tat-mediated HIV elongation 26 8.29e-03 -0.299000 3.82e-02
Tat-mediated HIV elongation arrest and recovery 26 8.29e-03 -0.299000 3.82e-02
Formation of HIV elongation complex in the absence of HIV Tat 37 1.76e-03 -0.297000 1.32e-02
Sulfur amino acid metabolism 17 3.52e-02 -0.295000 1.09e-01
B-WICH complex positively regulates rRNA expression 27 8.36e-03 -0.293000 3.84e-02
Ubiquitin-dependent degradation of Cyclin D 44 7.98e-04 -0.292000 8.02e-03
mRNA decay by 5’ to 3’ exoribonuclease 15 5.00e-02 -0.292000 1.40e-01
Diseases associated with glycosylation precursor biosynthesis 15 5.02e-02 -0.292000 1.40e-01
GAB1 signalosome 10 1.14e-01 -0.289000 2.41e-01
NRIF signals cell death from the nucleus 14 6.21e-02 -0.288000 1.62e-01
Base-Excision Repair, AP Site Formation 15 5.36e-02 -0.288000 1.48e-01
G1/S-Specific Transcription 27 9.92e-03 -0.287000 4.30e-02
Transcription of the HIV genome 57 1.85e-04 -0.286000 3.37e-03
Interactions of Vpr with host cellular proteins 33 4.60e-03 -0.285000 2.44e-02
Rev-mediated nuclear export of HIV RNA 33 4.76e-03 -0.284000 2.51e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 36 3.25e-03 -0.284000 1.93e-02
HIV Transcription Elongation 36 3.25e-03 -0.284000 1.93e-02
Tat-mediated elongation of the HIV-1 transcript 36 3.25e-03 -0.284000 1.93e-02
Resolution of Sister Chromatid Cohesion 92 2.66e-06 -0.284000 1.10e-04
Elastic fibre formation 17 4.31e-02 0.283000 1.25e-01
Degradation of GLI1 by the proteasome 51 4.69e-04 -0.283000 5.43e-03
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 16 5.01e-02 -0.283000 1.40e-01
Constitutive Signaling by EGFRvIII 10 1.22e-01 -0.282000 2.55e-01
Signaling by EGFRvIII in Cancer 10 1.22e-01 -0.282000 2.55e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 46 9.30e-04 -0.282000 8.67e-03
Interactions of Rev with host cellular proteins 34 4.49e-03 -0.282000 2.42e-02
AURKA Activation by TPX2 59 1.93e-04 -0.281000 3.37e-03
Signaling by FGFR in disease 39 2.44e-03 -0.281000 1.58e-02
HDR through Single Strand Annealing (SSA) 35 4.08e-03 -0.281000 2.28e-02
ERKs are inactivated 11 1.07e-01 -0.280000 2.35e-01
Vpr-mediated nuclear import of PICs 32 6.08e-03 -0.280000 3.00e-02
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 1.08e-01 -0.280000 2.35e-01
ER-Phagosome pathway 69 5.86e-05 -0.280000 1.26e-03
Gap-filling DNA repair synthesis and ligation in TC-NER 55 3.44e-04 -0.279000 4.60e-03
Diseases associated with N-glycosylation of proteins 18 4.05e-02 -0.279000 1.20e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 1.07e-03 -0.279000 9.52e-03
Dual incision in TC-NER 56 3.10e-04 -0.279000 4.19e-03
RNA Polymerase II Pre-transcription Events 68 7.59e-05 -0.278000 1.57e-03
Polo-like kinase mediated events 15 6.26e-02 -0.278000 1.63e-01
Glucose metabolism 72 4.89e-05 -0.277000 1.20e-03
Lagging Strand Synthesis 17 4.89e-02 -0.276000 1.38e-01
Regulation of PTEN stability and activity 56 3.61e-04 -0.276000 4.68e-03
RNA Polymerase III Transcription Initiation From Type 2 Promoter 26 1.51e-02 -0.275000 5.76e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 6.53e-02 -0.275000 1.68e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 27 1.35e-02 -0.275000 5.32e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 83 1.56e-05 -0.275000 4.70e-04
Amplification of signal from the kinetochores 83 1.56e-05 -0.275000 4.70e-04
Platelet calcium homeostasis 17 5.03e-02 -0.274000 1.40e-01
Ovarian tumor domain proteases 29 1.07e-02 -0.274000 4.51e-02
Formation of RNA Pol II elongation complex 50 8.15e-04 -0.274000 8.02e-03
RNA Polymerase II Transcription Elongation 50 8.15e-04 -0.274000 8.02e-03
G2/M DNA damage checkpoint 54 5.15e-04 -0.273000 5.79e-03
APC truncation mutants have impaired AXIN binding 12 1.01e-01 -0.273000 2.26e-01
AXIN missense mutants destabilize the destruction complex 12 1.01e-01 -0.273000 2.26e-01
Signaling by AMER1 mutants 12 1.01e-01 -0.273000 2.26e-01
Signaling by APC mutants 12 1.01e-01 -0.273000 2.26e-01
Signaling by AXIN mutants 12 1.01e-01 -0.273000 2.26e-01
Truncations of AMER1 destabilize the destruction complex 12 1.01e-01 -0.273000 2.26e-01
SCF(Skp2)-mediated degradation of p27/p21 52 6.73e-04 -0.273000 6.98e-03
Diseases of DNA repair 45 1.68e-03 -0.271000 1.28e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 3.64e-02 -0.270000 1.11e-01
Neurodegenerative Diseases 20 3.64e-02 -0.270000 1.11e-01
Sema4D induced cell migration and growth-cone collapse 12 1.05e-01 0.270000 2.31e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 16 6.23e-02 -0.269000 1.62e-01
Autodegradation of the E3 ubiquitin ligase COP1 44 2.02e-03 -0.269000 1.44e-02
Processive synthesis on the lagging strand 13 9.35e-02 -0.269000 2.16e-01
Keratan sulfate/keratin metabolism 18 4.91e-02 -0.268000 1.38e-01
Antigen processing-Cross presentation 76 5.80e-05 -0.267000 1.26e-03
SCF-beta-TrCP mediated degradation of Emi1 47 1.58e-03 -0.267000 1.25e-02
Vif-mediated degradation of APOBEC3G 43 2.53e-03 -0.266000 1.62e-02
DNA strand elongation 28 1.48e-02 -0.266000 5.69e-02
Notch-HLH transcription pathway 21 3.60e-02 -0.264000 1.10e-01
Degradation of AXIN 47 1.72e-03 -0.264000 1.31e-02
Signaling by FLT3 ITD and TKD mutants 12 1.13e-01 -0.264000 2.41e-01
Class A/1 (Rhodopsin-like receptors) 49 1.41e-03 0.264000 1.18e-02
Negative regulation of NOTCH4 signaling 48 1.59e-03 -0.264000 1.25e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 1.17e-01 -0.262000 2.45e-01
Mitochondrial Fatty Acid Beta-Oxidation 26 2.16e-02 -0.260000 7.46e-02
Telomere C-strand (Lagging Strand) Synthesis 29 1.54e-02 -0.260000 5.83e-02
mRNA Splicing - Minor Pathway 49 1.65e-03 -0.260000 1.28e-02
Defective Intrinsic Pathway for Apoptosis 23 3.15e-02 -0.259000 1.00e-01
Negative regulators of DDX58/IFIH1 signaling 34 8.99e-03 -0.259000 4.05e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 45 2.81e-03 -0.258000 1.75e-02
Downstream signal transduction 20 4.70e-02 -0.257000 1.34e-01
Beta-catenin phosphorylation cascade 15 8.61e-02 -0.256000 2.03e-01
Translesion synthesis by POLI 15 8.63e-02 -0.256000 2.03e-01
Transport of the SLBP Dependant Mature mRNA 34 9.88e-03 -0.256000 4.30e-02
Vpu mediated degradation of CD4 44 3.36e-03 -0.256000 1.97e-02
Transport of the SLBP independent Mature mRNA 33 1.11e-02 -0.256000 4.66e-02
Diseases of programmed cell death 37 7.16e-03 -0.256000 3.40e-02
EML4 and NUDC in mitotic spindle formation 87 4.10e-05 -0.255000 1.09e-03
Separation of Sister Chromatids 147 1.07e-07 -0.254000 7.54e-06
Cyclin E associated events during G1/S transition 72 2.00e-04 -0.254000 3.38e-03
Recruitment of NuMA to mitotic centrosomes 65 4.30e-04 -0.253000 5.26e-03
Regulation of RUNX2 expression and activity 57 9.76e-04 -0.253000 8.75e-03
Cyclin A:Cdk2-associated events at S phase entry 74 1.74e-04 -0.253000 3.22e-03
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 69 2.90e-04 -0.253000 4.05e-03
Transcriptional regulation by small RNAs 45 3.47e-03 -0.252000 2.00e-02
Chromosome Maintenance 78 1.23e-04 -0.252000 2.31e-03
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 4.78e-03 -0.252000 2.51e-02
Formation of TC-NER Pre-Incision Complex 46 3.17e-03 -0.252000 1.93e-02
RNA Polymerase III Transcription Termination 21 4.62e-02 -0.251000 1.32e-01
DNA Damage/Telomere Stress Induced Senescence 24 3.33e-02 -0.251000 1.05e-01
Unwinding of DNA 11 1.51e-01 -0.250000 2.96e-01
Processive synthesis on the C-strand of the telomere 17 7.49e-02 -0.249000 1.85e-01
Mitotic Prometaphase 158 6.82e-08 -0.249000 5.13e-06
Export of Viral Ribonucleoproteins from Nucleus 31 1.64e-02 -0.249000 6.17e-02
Heme signaling 26 2.80e-02 -0.249000 9.10e-02
RUNX3 regulates NOTCH signaling 11 1.53e-01 -0.249000 2.99e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 88 5.59e-05 -0.249000 1.26e-03
Nonsense-Mediated Decay (NMD) 88 5.59e-05 -0.249000 1.26e-03
TP53 Regulates Transcription of Cell Cycle Genes 43 4.84e-03 -0.248000 2.51e-02
Regulation of Apoptosis 45 4.12e-03 -0.247000 2.29e-02
Synaptic adhesion-like molecules 10 1.77e-01 0.246000 3.25e-01
Signaling by Retinoic Acid 17 7.87e-02 -0.246000 1.91e-01
Sema4D in semaphorin signaling 15 9.91e-02 0.246000 2.25e-01
Host Interactions of HIV factors 106 1.28e-05 -0.246000 4.27e-04
Regulation of ornithine decarboxylase (ODC) 43 5.40e-03 -0.245000 2.76e-02
Hedgehog ligand biogenesis 52 2.28e-03 -0.245000 1.52e-02
TP53 Regulates Transcription of DNA Repair Genes 52 2.41e-03 -0.243000 1.57e-02
TNFR1-induced NFkappaB signaling pathway 20 5.99e-02 -0.243000 1.59e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 4.46e-03 -0.242000 2.41e-02
Ub-specific processing proteases 134 1.32e-06 -0.242000 6.09e-05
Dectin-1 mediated noncanonical NF-kB signaling 52 2.52e-03 -0.242000 1.62e-02
Regulation of RAS by GAPs 56 1.77e-03 -0.242000 1.32e-02
Rap1 signalling 11 1.66e-01 -0.241000 3.12e-01
Influenza Infection 130 2.10e-06 -0.241000 9.00e-05
G1/S DNA Damage Checkpoints 58 1.52e-03 -0.241000 1.22e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 52 2.69e-03 -0.241000 1.69e-02
Regulation of expression of SLITs and ROBOs 124 3.83e-06 -0.241000 1.49e-04
Early Phase of HIV Life Cycle 13 1.34e-01 -0.240000 2.72e-01
Glyoxylate metabolism and glycine degradation 19 7.04e-02 -0.240000 1.77e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 74 3.72e-04 -0.239000 4.76e-03
Impaired BRCA2 binding to RAD51 32 1.96e-02 -0.238000 6.94e-02
Telomere Maintenance 57 1.87e-03 -0.238000 1.35e-02
NIK–>noncanonical NF-kB signaling 51 3.33e-03 -0.238000 1.97e-02
Cleavage of the damaged pyrimidine 14 1.23e-01 -0.238000 2.55e-01
Depyrimidination 14 1.23e-01 -0.238000 2.55e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 14 1.23e-01 -0.238000 2.55e-01
SUMOylation of SUMOylation proteins 32 2.01e-02 -0.238000 7.08e-02
Removal of the Flap Intermediate 12 1.54e-01 -0.238000 2.99e-01
Degradation of beta-catenin by the destruction complex 68 7.14e-04 -0.238000 7.34e-03
CLEC7A (Dectin-1) induces NFAT activation 11 1.74e-01 -0.237000 3.23e-01
Influenza Viral RNA Transcription and Replication 113 1.41e-05 -0.237000 4.57e-04
Nuclear import of Rev protein 31 2.26e-02 -0.237000 7.75e-02
Glycolysis 57 2.05e-03 -0.236000 1.45e-02
Estrogen-dependent gene expression 70 6.43e-04 -0.236000 6.90e-03
Centrosome maturation 66 9.59e-04 -0.235000 8.73e-03
Recruitment of mitotic centrosome proteins and complexes 66 9.59e-04 -0.235000 8.73e-03
ERK/MAPK targets 16 1.03e-01 -0.235000 2.30e-01
RHO GTPases Activate Formins 102 4.21e-05 -0.235000 1.10e-03
Signaling by NOTCH2 18 8.48e-02 -0.235000 2.03e-01
NEP/NS2 Interacts with the Cellular Export Machinery 30 2.62e-02 -0.235000 8.71e-02
Mitochondrial iron-sulfur cluster biogenesis 12 1.60e-01 -0.234000 3.04e-01
Glycogen metabolism 17 9.44e-02 -0.234000 2.17e-01
Synthesis of IP3 and IP4 in the cytosol 16 1.05e-01 -0.234000 2.31e-01
Signaling by ALK 18 8.70e-02 -0.233000 2.04e-01
Polymerase switching on the C-strand of the telomere 22 5.92e-02 -0.232000 1.58e-01
CTNNB1 S33 mutants aren’t phosphorylated 13 1.49e-01 -0.231000 2.93e-01
CTNNB1 S37 mutants aren’t phosphorylated 13 1.49e-01 -0.231000 2.93e-01
CTNNB1 S45 mutants aren’t phosphorylated 13 1.49e-01 -0.231000 2.93e-01
CTNNB1 T41 mutants aren’t phosphorylated 13 1.49e-01 -0.231000 2.93e-01
Signaling by CTNNB1 phospho-site mutants 13 1.49e-01 -0.231000 2.93e-01
Signaling by GSK3beta mutants 13 1.49e-01 -0.231000 2.93e-01
Mitotic Spindle Checkpoint 98 8.04e-05 -0.231000 1.64e-03
Nucleotide Excision Repair 99 7.59e-05 -0.230000 1.57e-03
TBC/RABGAPs 40 1.18e-02 -0.230000 4.84e-02
Defective pyroptosis 10 2.08e-01 -0.230000 3.66e-01
RORA activates gene expression 11 1.87e-01 -0.230000 3.40e-01
Transport of Ribonucleoproteins into the Host Nucleus 30 2.97e-02 -0.229000 9.57e-02
Base Excision Repair 38 1.45e-02 -0.229000 5.60e-02
Gene Silencing by RNA 62 1.83e-03 -0.229000 1.34e-02
Cell-cell junction organization 13 1.53e-01 0.229000 2.99e-01
Ion homeostasis 26 4.37e-02 -0.229000 1.27e-01
SRP-dependent cotranslational protein targeting to membrane 88 2.16e-04 -0.228000 3.47e-03
Nucleotide biosynthesis 12 1.72e-01 -0.227000 3.21e-01
G-protein activation 13 1.56e-01 0.227000 3.00e-01
Long-term potentiation 11 1.94e-01 0.226000 3.49e-01
InlB-mediated entry of Listeria monocytogenes into host cell 11 1.95e-01 -0.226000 3.49e-01
HCMV Early Events 50 5.89e-03 -0.225000 2.92e-02
LDL clearance 12 1.77e-01 -0.225000 3.25e-01
p53-Dependent G1 DNA Damage Response 56 3.66e-03 -0.225000 2.10e-02
p53-Dependent G1/S DNA damage checkpoint 56 3.66e-03 -0.225000 2.10e-02
Metabolism of water-soluble vitamins and cofactors 82 4.51e-04 -0.224000 5.26e-03
Depolymerisation of the Nuclear Lamina 13 1.61e-01 0.224000 3.06e-01
Potassium Channels 30 3.38e-02 0.224000 1.05e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 63 2.13e-03 -0.224000 1.47e-02
Regulation of PTEN mRNA translation 11 2.00e-01 0.223000 3.55e-01
Asymmetric localization of PCP proteins 51 5.86e-03 -0.223000 2.92e-02
Selenoamino acid metabolism 78 6.67e-04 -0.223000 6.98e-03
Homologous DNA Pairing and Strand Exchange 39 1.64e-02 -0.222000 6.17e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 62 2.55e-03 -0.222000 1.62e-02
Cap-dependent Translation Initiation 95 1.93e-04 -0.222000 3.37e-03
Eukaryotic Translation Initiation 95 1.93e-04 -0.222000 3.37e-03
Regulation of RUNX3 expression and activity 49 7.31e-03 -0.222000 3.46e-02
Pyruvate metabolism 20 8.63e-02 -0.222000 2.03e-01
MAPK6/MAPK4 signaling 69 1.47e-03 -0.222000 1.20e-02
HIV Life Cycle 129 1.47e-05 -0.221000 4.66e-04
APC/C:Cdc20 mediated degradation of mitotic proteins 65 2.08e-03 -0.221000 1.45e-02
RAC3 GTPase cycle 59 3.37e-03 0.221000 1.97e-02
Nuclear events mediated by NFE2L2 67 1.81e-03 -0.221000 1.33e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 66 1.97e-03 -0.220000 1.41e-02
Retrograde transport at the Trans-Golgi-Network 45 1.06e-02 -0.220000 4.48e-02
Translesion synthesis by REV1 14 1.54e-01 -0.220000 2.99e-01
Processing of DNA double-strand break ends 55 4.82e-03 -0.220000 2.51e-02
Transcription of E2F targets under negative control by DREAM complex 18 1.06e-01 -0.220000 2.33e-01
Regulation of IFNA/IFNB signaling 12 1.87e-01 -0.220000 3.40e-01
Signaling by NOTCH4 68 1.77e-03 -0.219000 1.32e-02
Eukaryotic Translation Termination 72 1.32e-03 -0.219000 1.11e-02
G1/S Transition 115 5.10e-05 -0.219000 1.23e-03
Late Phase of HIV Life Cycle 117 4.53e-05 -0.219000 1.16e-03
Branched-chain amino acid catabolism 20 9.06e-02 -0.219000 2.09e-01
Cellular response to hypoxia 60 3.45e-03 -0.218000 2.00e-02
G2/M Checkpoints 119 4.02e-05 -0.218000 1.09e-03
Regulation of PLK1 Activity at G2/M Transition 74 1.18e-03 -0.218000 1.02e-02
Hh mutants abrogate ligand secretion 49 8.30e-03 -0.218000 3.82e-02
Leading Strand Synthesis 12 1.91e-01 -0.218000 3.44e-01
Polymerase switching 12 1.91e-01 -0.218000 3.44e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 1.58e-01 -0.218000 3.03e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 1.58e-01 -0.218000 3.03e-01
Regulation of TP53 Activity through Phosphorylation 79 8.37e-04 -0.218000 8.12e-03
HIV Infection 190 2.59e-07 -0.217000 1.41e-05
Stabilization of p53 49 8.54e-03 -0.217000 3.90e-02
G0 and Early G1 24 6.57e-02 -0.217000 1.68e-01
RIPK1-mediated regulated necrosis 25 6.11e-02 -0.216000 1.60e-01
Regulation of necroptotic cell death 25 6.11e-02 -0.216000 1.60e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 18 1.12e-01 -0.216000 2.40e-01
Cell Cycle Checkpoints 228 2.04e-08 -0.216000 1.88e-06
Sema3A PAK dependent Axon repulsion 11 2.14e-01 0.216000 3.71e-01
VEGFR2 mediated cell proliferation 16 1.34e-01 -0.216000 2.73e-01
Eukaryotic Translation Elongation 72 1.55e-03 -0.216000 1.24e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 28 4.80e-02 -0.216000 1.36e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 28 4.80e-02 -0.216000 1.36e-01
Hh mutants are degraded by ERAD 47 1.05e-02 -0.216000 4.48e-02
Collagen degradation 14 1.62e-01 0.216000 3.07e-01
Mitotic Metaphase and Anaphase 196 2.11e-07 -0.216000 1.32e-05
SUMOylation of intracellular receptors 19 1.04e-01 -0.215000 2.30e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 84 6.66e-04 -0.215000 6.98e-03
Resolution of Abasic Sites (AP sites) 31 3.85e-02 -0.215000 1.16e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 53 6.89e-03 -0.215000 3.31e-02
UCH proteinases 74 1.47e-03 -0.214000 1.20e-02
Telomere C-strand synthesis initiation 10 2.41e-01 -0.214000 4.08e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 41 1.81e-02 -0.213000 6.68e-02
Deubiquitination 198 2.50e-07 -0.213000 1.41e-05
DDX58/IFIH1-mediated induction of interferon-alpha/beta 58 5.10e-03 -0.213000 2.63e-02
RNA Polymerase I Promoter Escape 27 5.59e-02 -0.213000 1.52e-01
Activation of HOX genes during differentiation 41 1.86e-02 -0.213000 6.78e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 41 1.86e-02 -0.213000 6.78e-02
Meiotic recombination 19 1.09e-01 -0.212000 2.37e-01
Mitotic Anaphase 195 3.54e-07 -0.212000 1.85e-05
Selenocysteine synthesis 70 2.19e-03 -0.212000 1.48e-02
Cilium Assembly 150 7.81e-06 -0.212000 2.81e-04
Peptide chain elongation 69 2.36e-03 -0.212000 1.55e-02
Postmitotic nuclear pore complex (NPC) reformation 26 6.19e-02 -0.212000 1.62e-01
Organelle biogenesis and maintenance 204 2.20e-07 -0.211000 1.32e-05
Triglyceride metabolism 16 1.44e-01 -0.211000 2.87e-01
Interleukin-6 family signaling 13 1.88e-01 -0.211000 3.40e-01
Translation 238 2.54e-08 -0.210000 2.18e-06
Formation of a pool of free 40S subunits 78 1.34e-03 -0.210000 1.13e-02
Hedgehog ‘off’ state 75 1.68e-03 -0.210000 1.28e-02
Positive epigenetic regulation of rRNA expression 40 2.16e-02 -0.210000 7.46e-02
Signaling by ROBO receptors 154 7.31e-06 -0.210000 2.74e-04
Post-chaperonin tubulin folding pathway 13 1.91e-01 -0.209000 3.44e-01
CLEC7A (Dectin-1) signaling 84 9.38e-04 -0.209000 8.68e-03
NS1 Mediated Effects on Host Pathways 38 2.61e-02 -0.209000 8.71e-02
Transport of Mature Transcript to Cytoplasm 64 3.95e-03 -0.208000 2.23e-02
Citric acid cycle (TCA cycle) 19 1.16e-01 -0.208000 2.45e-01
Mitotic G1 phase and G1/S transition 129 4.72e-05 -0.208000 1.18e-03
Interleukin-1 signaling 79 1.47e-03 -0.207000 1.20e-02
Diseases associated with glycosaminoglycan metabolism 16 1.51e-01 -0.207000 2.97e-01
Regulation of APC/C activators between G1/S and early anaphase 70 2.79e-03 -0.207000 1.75e-02
Hedgehog ‘on’ state 63 4.59e-03 -0.207000 2.44e-02
RHOD GTPase cycle 36 3.21e-02 0.206000 1.02e-01
Metabolism of carbohydrates 181 1.80e-06 -0.206000 7.99e-05
Thrombin signalling through proteinase activated receptors (PARs) 20 1.12e-01 0.205000 2.39e-01
Degradation of DVL 48 1.40e-02 -0.205000 5.47e-02
Defective CFTR causes cystic fibrosis 52 1.06e-02 -0.205000 4.48e-02
tRNA processing in the nucleus 55 8.60e-03 -0.205000 3.92e-02
APC/C:Cdc20 mediated degradation of Securin 58 7.10e-03 -0.205000 3.40e-02
Platelet sensitization by LDL 13 2.02e-01 -0.204000 3.57e-01
Interleukin-20 family signaling 13 2.02e-01 -0.204000 3.57e-01
RNA polymerase II transcribes snRNA genes 71 2.98e-03 -0.204000 1.84e-02
Homology Directed Repair 90 8.49e-04 -0.204000 8.16e-03
Mitochondrial biogenesis 54 9.72e-03 -0.204000 4.26e-02
M Phase 297 2.02e-09 -0.203000 2.43e-07
Mitochondrial protein import 48 1.49e-02 -0.203000 5.71e-02
APC/C-mediated degradation of cell cycle proteins 77 2.09e-03 -0.203000 1.45e-02
Regulation of mitotic cell cycle 77 2.09e-03 -0.203000 1.45e-02
Presynaptic phase of homologous DNA pairing and strand exchange 36 3.56e-02 -0.203000 1.10e-01
CD28 dependent PI3K/Akt signaling 18 1.38e-01 -0.202000 2.78e-01
Signaling by FGFR2 48 1.56e-02 -0.202000 5.89e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency 78 2.21e-03 -0.201000 1.48e-02
Nuclear Receptor transcription pathway 27 7.12e-02 -0.201000 1.78e-01
RNA Polymerase III Chain Elongation 17 1.52e-01 -0.201000 2.97e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 88 1.16e-03 -0.201000 1.01e-02
ABC transporter disorders 59 8.06e-03 -0.200000 3.77e-02
Activation of gene expression by SREBF (SREBP) 36 3.88e-02 -0.199000 1.16e-01
Viral mRNA Translation 69 4.30e-03 -0.199000 2.37e-02
PCNA-Dependent Long Patch Base Excision Repair 18 1.44e-01 -0.199000 2.87e-01
Mitotic G2-G2/M phases 158 1.70e-05 -0.199000 4.99e-04
HDR through Homologous Recombination (HRR) 60 7.94e-03 -0.198000 3.73e-02
FCERI mediated NF-kB activation 64 6.21e-03 -0.198000 3.05e-02
RNA Polymerase III Abortive And Retractive Initiation 39 3.26e-02 -0.198000 1.02e-01
RNA Polymerase III Transcription 39 3.26e-02 -0.198000 1.02e-01
COPI-dependent Golgi-to-ER retrograde traffic 66 5.50e-03 -0.198000 2.80e-02
Metabolism of polyamines 48 1.81e-02 -0.197000 6.68e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 10 2.81e-01 0.197000 4.56e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 2.58e-01 -0.197000 4.30e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 48 1.84e-02 -0.197000 6.78e-02
Chaperone Mediated Autophagy 12 2.38e-01 -0.197000 4.04e-01
Cyclin A/B1/B2 associated events during G2/M transition 22 1.10e-01 -0.197000 2.37e-01
DNA Double-Strand Break Repair 117 2.49e-04 -0.196000 3.79e-03
Signaling by KIT in disease 16 1.74e-01 -0.196000 3.23e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 16 1.74e-01 -0.196000 3.23e-01
Translesion synthesis by POLK 15 1.89e-01 -0.196000 3.42e-01
G2/M Transition 156 2.62e-05 -0.195000 7.51e-04
Regulation of pyruvate dehydrogenase (PDH) complex 11 2.63e-01 -0.195000 4.35e-01
Autodegradation of Cdh1 by Cdh1:APC/C 56 1.18e-02 -0.195000 4.84e-02
Signaling by CSF3 (G-CSF) 24 9.92e-02 -0.194000 2.25e-01
Cytoprotection by HMOX1 44 2.57e-02 -0.194000 8.68e-02
L13a-mediated translational silencing of Ceruloplasmin expression 87 1.75e-03 -0.194000 1.32e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 37 4.12e-02 -0.194000 1.21e-01
Diseases of DNA Double-Strand Break Repair 37 4.12e-02 -0.194000 1.21e-01
Metabolism of vitamins and cofactors 111 4.28e-04 -0.194000 5.26e-03
KEAP1-NFE2L2 pathway 86 1.94e-03 -0.194000 1.40e-02
Activation of NF-kappaB in B cells 57 1.22e-02 -0.192000 4.96e-02
Condensation of Prometaphase Chromosomes 10 2.93e-01 -0.192000 4.66e-01
Nucleotide catabolism 21 1.28e-01 -0.192000 2.63e-01
Orc1 removal from chromatin 62 9.16e-03 -0.192000 4.11e-02
SUMOylation of ubiquitinylation proteins 37 4.39e-02 -0.191000 1.27e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 83 2.68e-03 -0.191000 1.69e-02
Drug ADME 27 8.63e-02 -0.191000 2.03e-01
SHC1 events in ERBB2 signaling 11 2.74e-01 0.190000 4.48e-01
S Phase 141 9.91e-05 -0.190000 1.89e-03
COPI-mediated anterograde transport 71 5.67e-03 -0.190000 2.86e-02
Diseases associated with O-glycosylation of proteins 21 1.33e-01 0.190000 2.70e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 57 1.36e-02 -0.189000 5.34e-02
Cell Cycle, Mitotic 425 3.18e-11 -0.189000 6.38e-09
E3 ubiquitin ligases ubiquitinate target proteins 41 3.64e-02 -0.189000 1.11e-01
Semaphorin interactions 39 4.16e-02 0.189000 1.22e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 88 2.36e-03 -0.188000 1.55e-02
Methylation 10 3.04e-01 -0.188000 4.80e-01
RNA Polymerase I Transcription Termination 25 1.05e-01 -0.187000 2.31e-01
DNA Repair 248 4.23e-07 -0.187000 2.12e-05
Complex I biogenesis 43 3.37e-02 -0.187000 1.05e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 10 3.06e-01 -0.187000 4.82e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 64 9.72e-03 -0.187000 4.26e-02
The citric acid (TCA) cycle and respiratory electron transport 121 3.92e-04 -0.187000 4.96e-03
RNA Polymerase I Transcription Initiation 40 4.11e-02 -0.187000 1.21e-01
p75NTR signals via NF-kB 11 2.84e-01 -0.187000 4.59e-01
Cell Cycle 530 3.48e-13 -0.186000 1.04e-10
CDK-mediated phosphorylation and removal of Cdc6 62 1.14e-02 -0.186000 4.74e-02
IKK complex recruitment mediated by RIP1 17 1.87e-01 -0.185000 3.40e-01
TICAM1-dependent activation of IRF3/IRF7 12 2.68e-01 -0.185000 4.42e-01
Cargo trafficking to the periciliary membrane 40 4.39e-02 -0.184000 1.27e-01
RHO GTPases activate CIT 14 2.33e-01 -0.184000 3.98e-01
Respiratory electron transport 82 4.08e-03 -0.184000 2.28e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 23 1.28e-01 -0.183000 2.63e-01
Golgi-to-ER retrograde transport 95 2.20e-03 -0.182000 1.48e-02
ABC-family proteins mediated transport 74 6.86e-03 -0.182000 3.31e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation 23 1.32e-01 -0.182000 2.69e-01
Diseases of mitotic cell cycle 34 6.72e-02 -0.181000 1.71e-01
RNA Polymerase II Transcription Termination 45 3.58e-02 -0.181000 1.10e-01
Formation of Incision Complex in GG-NER 36 6.12e-02 -0.180000 1.60e-01
Dual Incision in GG-NER 35 6.49e-02 -0.180000 1.67e-01
GPCR ligand binding 80 5.60e-03 0.179000 2.84e-02
Chaperonin-mediated protein folding 57 1.93e-02 -0.179000 6.89e-02
Cellular response to chemical stress 145 2.06e-04 -0.179000 3.39e-03
Nuclear Pore Complex (NPC) Disassembly 34 7.11e-02 -0.179000 1.78e-01
Meiosis 42 4.53e-02 -0.179000 1.30e-01
Protein folding 63 1.44e-02 -0.178000 5.57e-02
Circadian Clock 52 2.67e-02 -0.178000 8.78e-02
Glycogen storage diseases 10 3.31e-01 -0.178000 5.13e-01
Glutathione conjugation 21 1.59e-01 -0.178000 3.04e-01
Translation of Structural Proteins 27 1.11e-01 -0.177000 2.39e-01
tRNA processing 93 3.34e-03 -0.176000 1.97e-02
Downstream signaling of activated FGFR1 12 2.92e-01 -0.176000 4.65e-01
Downstream signaling of activated FGFR2 12 2.92e-01 -0.176000 4.65e-01
Downstream signaling of activated FGFR3 12 2.92e-01 -0.176000 4.65e-01
Downstream signaling of activated FGFR4 12 2.92e-01 -0.176000 4.65e-01
Removal of the Flap Intermediate from the C-strand 15 2.39e-01 -0.176000 4.05e-01
Inactivation of CSF3 (G-CSF) signaling 19 1.85e-01 -0.176000 3.37e-01
FLT3 signaling in disease 24 1.38e-01 -0.175000 2.78e-01
Formation of the ternary complex, and subsequently, the 43S complex 40 5.58e-02 -0.175000 1.52e-01
Metabolism of non-coding RNA 48 3.65e-02 -0.175000 1.11e-01
snRNP Assembly 48 3.65e-02 -0.175000 1.11e-01
Signaling by Nuclear Receptors 151 2.26e-04 -0.174000 3.58e-03
RHOF GTPase cycle 25 1.32e-01 0.174000 2.69e-01
Miscellaneous transport and binding events 14 2.60e-01 -0.174000 4.31e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 10 3.42e-01 -0.173000 5.24e-01
Condensation of Prophase Chromosomes 12 2.99e-01 -0.173000 4.73e-01
Metabolism of amino acids and derivatives 225 8.42e-06 -0.173000 2.89e-04
Signaling by EGFR in Cancer 16 2.32e-01 -0.173000 3.95e-01
ZBP1(DAI) mediated induction of type I IFNs 17 2.18e-01 -0.172000 3.77e-01
Metabolism of porphyrins 15 2.49e-01 -0.172000 4.17e-01
Metabolism of nucleotides 73 1.15e-02 -0.171000 4.77e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 77 9.47e-03 -0.171000 4.23e-02
HCMV Infection 71 1.28e-02 -0.171000 5.13e-02
Transcriptional regulation by RUNX2 84 6.82e-03 -0.171000 3.31e-02
Global Genome Nucleotide Excision Repair (GG-NER) 76 1.02e-02 -0.171000 4.40e-02
Downstream TCR signaling 71 1.31e-02 -0.170000 5.19e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 33 9.03e-02 -0.170000 2.09e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 2.54e-01 -0.170000 4.24e-01
N-Glycan antennae elongation 10 3.52e-01 -0.170000 5.32e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 29 1.14e-01 0.170000 2.41e-01
RUNX3 regulates p14-ARF 10 3.53e-01 -0.170000 5.32e-01
Processing of Capped Intron-Containing Pre-mRNA 199 3.98e-05 -0.169000 1.09e-03
Downstream signaling events of B Cell Receptor (BCR) 70 1.47e-02 -0.169000 5.65e-02
Diseases of signal transduction by growth factor receptors and second messengers 299 6.46e-07 -0.168000 3.11e-05
Signaling by Hedgehog 99 3.89e-03 -0.168000 2.21e-02
SARS-CoV-2-host interactions 150 3.98e-04 -0.168000 4.98e-03
Aberrant regulation of mitotic cell cycle due to RB1 defects 33 9.56e-02 -0.168000 2.19e-01
SUMOylation of DNA replication proteins 43 5.75e-02 -0.167000 1.54e-01
RNA Polymerase III Transcription Initiation 35 8.74e-02 -0.167000 2.04e-01
RNA Polymerase I Promoter Clearance 44 5.57e-02 -0.167000 1.52e-01
RNA Polymerase I Transcription 44 5.57e-02 -0.167000 1.52e-01
Signaling by FGFR 52 3.77e-02 -0.167000 1.14e-01
ATF4 activates genes in response to endoplasmic reticulum stress 23 1.67e-01 -0.167000 3.13e-01
Metabolism of cofactors 17 2.35e-01 -0.166000 4.00e-01
Interleukin-12 family signaling 42 6.30e-02 -0.166000 1.63e-01
ESR-mediated signaling 115 2.17e-03 -0.166000 1.48e-02
Interleukin-1 family signaling 99 4.60e-03 -0.165000 2.44e-02
Disease 1086 2.47e-19 -0.165000 2.96e-16
Intra-Golgi and retrograde Golgi-to-ER traffic 158 3.62e-04 -0.165000 4.68e-03
DNA Double Strand Break Response 36 8.72e-02 -0.165000 2.04e-01
Post-translational modification: synthesis of GPI-anchored proteins 31 1.12e-01 -0.165000 2.40e-01
Azathioprine ADME 15 2.70e-01 -0.165000 4.43e-01
SARS-CoV-2 modulates autophagy 11 3.46e-01 -0.164000 5.27e-01
Transcriptional regulation by RUNX3 75 1.41e-02 -0.164000 5.49e-02
Constitutive Signaling by AKT1 E17K in Cancer 23 1.74e-01 -0.164000 3.23e-01
mRNA Splicing - Major Pathway 148 5.99e-04 -0.164000 6.66e-03
PERK regulates gene expression 26 1.50e-01 -0.163000 2.94e-01
Regulation of TNFR1 signaling 31 1.16e-01 -0.163000 2.45e-01
MHC class II antigen presentation 69 1.94e-02 -0.163000 6.90e-02
ISG15 antiviral mechanism 70 1.87e-02 -0.163000 6.79e-02
Frs2-mediated activation 11 3.52e-01 0.162000 5.32e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 20 2.09e-01 -0.162000 3.68e-01
Arachidonic acid metabolism 21 2.00e-01 0.161000 3.56e-01
Factors involved in megakaryocyte development and platelet production 87 9.60e-03 -0.161000 4.26e-02
Signaling by the B Cell Receptor (BCR) 90 8.70e-03 -0.160000 3.93e-02
Synthesis of DNA 106 4.55e-03 -0.160000 2.44e-02
Molecules associated with elastic fibres 12 3.39e-01 0.159000 5.22e-01
BBSome-mediated cargo-targeting to cilium 19 2.30e-01 -0.159000 3.93e-01
HATs acetylate histones 63 2.90e-02 -0.159000 9.38e-02
Signaling by Activin 12 3.41e-01 0.159000 5.23e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 55 4.21e-02 -0.159000 1.23e-01
Protein localization 123 2.45e-03 -0.158000 1.58e-02
Selective autophagy 50 5.35e-02 -0.158000 1.48e-01
Major pathway of rRNA processing in the nucleolus and cytosol 152 8.21e-04 -0.158000 8.02e-03
Peroxisomal lipid metabolism 22 2.01e-01 -0.157000 3.57e-01
Metabolism of RNA 553 4.01e-10 -0.157000 6.02e-08
C-type lectin receptors (CLRs) 100 6.77e-03 -0.157000 3.31e-02
Signaling by ERBB2 KD Mutants 12 3.48e-01 -0.157000 5.28e-01
Translation initiation complex formation 47 6.35e-02 -0.157000 1.64e-01
Phase II - Conjugation of compounds 46 6.68e-02 -0.156000 1.70e-01
Signaling by FLT3 fusion proteins 16 2.79e-01 -0.156000 4.55e-01
p75 NTR receptor-mediated signalling 59 3.86e-02 -0.156000 1.16e-01
Signaling by PDGF 25 1.79e-01 -0.155000 3.27e-01
Translesion Synthesis by POLH 17 2.68e-01 -0.155000 4.42e-01
Disorders of transmembrane transporters 111 4.82e-03 -0.155000 2.51e-02
PKMTs methylate histone lysines 31 1.35e-01 0.155000 2.73e-01
FOXO-mediated transcription of cell death genes 14 3.16e-01 -0.155000 4.95e-01
mRNA Splicing 158 8.05e-04 -0.155000 8.02e-03
Aggrephagy 19 2.43e-01 -0.155000 4.09e-01
Cyclin D associated events in G1 41 8.71e-02 -0.154000 2.04e-01
G1 Phase 41 8.71e-02 -0.154000 2.04e-01
Heme biosynthesis 10 3.98e-01 -0.154000 5.72e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 12 3.55e-01 0.154000 5.32e-01
Ribosomal scanning and start codon recognition 47 6.79e-02 -0.154000 1.71e-01
The phototransduction cascade 18 2.59e-01 0.154000 4.31e-01
Infectious disease 627 9.52e-11 -0.153000 1.63e-08
rRNA processing in the nucleus and cytosol 159 9.28e-04 -0.153000 8.67e-03
PCP/CE pathway 71 2.67e-02 -0.152000 8.78e-02
Extension of Telomeres 44 8.21e-02 -0.152000 1.98e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 3.85e-01 -0.151000 5.61e-01
RHO GTPases activate PKNs 26 1.82e-01 -0.151000 3.33e-01
DNA Damage Recognition in GG-NER 35 1.22e-01 -0.151000 2.55e-01
Caspase activation via Death Receptors in the presence of ligand 10 4.08e-01 -0.151000 5.79e-01
DNA Replication 113 5.69e-03 -0.151000 2.86e-02
Regulated Necrosis 43 8.80e-02 -0.150000 2.05e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 35 1.24e-01 -0.150000 2.56e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 28 1.69e-01 -0.150000 3.16e-01
Transcriptional Regulation by TP53 302 7.95e-06 -0.150000 2.81e-04
Apoptosis 133 2.89e-03 -0.150000 1.79e-02
Interferon alpha/beta signaling 51 6.43e-02 -0.150000 1.66e-01
PINK1-PRKN Mediated Mitophagy 20 2.46e-01 -0.150000 4.13e-01
MyD88-independent TLR4 cascade 74 2.65e-02 -0.149000 8.78e-02
TRIF(TICAM1)-mediated TLR4 signaling 74 2.65e-02 -0.149000 8.78e-02
EPH-ephrin mediated repulsion of cells 25 1.97e-01 -0.149000 3.52e-01
TP53 Regulates Metabolic Genes 71 3.02e-02 -0.149000 9.72e-02
AKT phosphorylates targets in the cytosol 13 3.54e-01 -0.149000 5.32e-01
mRNA 3’-end processing 37 1.18e-01 -0.149000 2.48e-01
rRNA processing 164 1.08e-03 -0.148000 9.52e-03
Resolution of D-Loop Structures 29 1.67e-01 -0.148000 3.14e-01
Neddylation 188 4.78e-04 -0.148000 5.47e-03
N-glycan antennae elongation in the medial/trans-Golgi 17 2.92e-01 -0.148000 4.65e-01
Termination of translesion DNA synthesis 28 1.76e-01 -0.148000 3.25e-01
Reproduction 48 7.70e-02 -0.148000 1.88e-01
Switching of origins to a post-replicative state 81 2.19e-02 -0.147000 7.55e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 48 7.73e-02 -0.147000 1.89e-01
Activation of ATR in response to replication stress 36 1.27e-01 -0.147000 2.62e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 3.78e-01 -0.147000 5.54e-01
Signaling by MET 41 1.04e-01 -0.147000 2.30e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 3.80e-01 -0.146000 5.55e-01
RHOH GTPase cycle 29 1.75e-01 0.146000 3.23e-01
SUMOylation of DNA methylation proteins 14 3.45e-01 0.146000 5.27e-01
Role of LAT2/NTAL/LAB on calcium mobilization 10 4.27e-01 -0.145000 5.91e-01
Intrinsic Pathway for Apoptosis 47 8.59e-02 -0.145000 2.03e-01
RIP-mediated NFkB activation via ZBP1 14 3.49e-01 -0.145000 5.29e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 21 2.52e-01 -0.144000 4.21e-01
Kinesins 32 1.58e-01 -0.144000 3.03e-01
Cell death signalling via NRAGE, NRIF and NADE 45 9.42e-02 -0.144000 2.17e-01
Plasma lipoprotein clearance 24 2.21e-01 -0.144000 3.82e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 41 1.10e-01 -0.144000 2.37e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 41 1.10e-01 -0.144000 2.37e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 41 1.10e-01 -0.144000 2.37e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 41 1.10e-01 -0.144000 2.37e-01
Signaling by NOTCH1 in Cancer 41 1.10e-01 -0.144000 2.37e-01
COPI-independent Golgi-to-ER retrograde traffic 29 1.79e-01 -0.144000 3.27e-01
Energy dependent regulation of mTOR by LKB1-AMPK 25 2.12e-01 -0.144000 3.71e-01
SARS-CoV-2 Infection 213 3.02e-04 -0.144000 4.13e-03
Peroxisomal protein import 48 8.55e-02 -0.144000 2.03e-01
Interleukin-15 signaling 11 4.10e-01 -0.144000 5.81e-01
Assembly of the pre-replicative complex 76 3.07e-02 -0.143000 9.83e-02
Negative regulation of MAPK pathway 36 1.36e-01 -0.143000 2.75e-01
Glycosphingolipid metabolism 27 1.97e-01 -0.143000 3.52e-01
Cellular response to starvation 120 6.86e-03 -0.143000 3.31e-02
ABC transporters in lipid homeostasis 10 4.33e-01 0.143000 5.97e-01
Plasma lipoprotein assembly, remodeling, and clearance 39 1.23e-01 -0.143000 2.55e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 35 1.44e-01 -0.143000 2.87e-01
Toll Like Receptor 4 (TLR4) Cascade 94 1.69e-02 -0.143000 6.32e-02
Recognition of DNA damage by PCNA-containing replication complex 26 2.09e-01 -0.142000 3.68e-01
Cell junction organization 26 2.11e-01 0.142000 3.69e-01
Nephrin family interactions 14 3.58e-01 -0.142000 5.36e-01
Regulation of TP53 Activity 136 4.44e-03 -0.142000 2.41e-02
ADP signalling through P2Y purinoceptor 1 16 3.28e-01 0.141000 5.11e-01
RMTs methylate histone arginines 25 2.22e-01 -0.141000 3.82e-01
Signaling by NTRK3 (TRKC) 11 4.18e-01 -0.141000 5.85e-01
RHO GTPase Effectors 188 8.84e-04 -0.141000 8.37e-03
DAG and IP3 signaling 26 2.15e-01 -0.140000 3.73e-01
RAC2 GTPase cycle 56 6.97e-02 0.140000 1.75e-01
HDR through MMEJ (alt-NHEJ) 11 4.21e-01 -0.140000 5.88e-01
Negative epigenetic regulation of rRNA expression 44 1.09e-01 -0.140000 2.37e-01
Activation of G protein gated Potassium channels 12 4.03e-01 0.139000 5.75e-01
G protein gated Potassium channels 12 4.03e-01 0.139000 5.75e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 12 4.03e-01 0.139000 5.75e-01
Keratan sulfate biosynthesis 14 3.67e-01 -0.139000 5.45e-01
Prostacyclin signalling through prostacyclin receptor 12 4.04e-01 0.139000 5.76e-01
Signaling by EGFR 35 1.55e-01 -0.139000 3.00e-01
Metabolism 1253 8.90e-16 -0.138000 5.35e-13
PRC2 methylates histones and DNA 12 4.07e-01 -0.138000 5.78e-01
Non-integrin membrane-ECM interactions 14 3.71e-01 0.138000 5.46e-01
G-protein mediated events 32 1.77e-01 -0.138000 3.25e-01
CD28 co-stimulation 27 2.16e-01 -0.138000 3.73e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 24 2.43e-01 -0.138000 4.09e-01
G beta:gamma signalling through BTK 11 4.30e-01 0.137000 5.94e-01
HCMV Late Events 51 8.98e-02 -0.137000 2.09e-01
Diseases of metabolism 126 7.89e-03 -0.137000 3.72e-02
Inwardly rectifying K+ channels 13 3.91e-01 0.137000 5.67e-01
VLDLR internalisation and degradation 11 4.32e-01 -0.137000 5.96e-01
TNF signaling 38 1.45e-01 -0.137000 2.88e-01
Cellular responses to stimuli 551 5.50e-08 -0.137000 4.40e-06
Hyaluronan uptake and degradation 10 4.54e-01 -0.137000 6.23e-01
ECM proteoglycans 13 3.94e-01 0.137000 5.69e-01
Antiviral mechanism by IFN-stimulated genes 77 3.97e-02 -0.136000 1.18e-01
Diseases of carbohydrate metabolism 23 2.60e-01 -0.136000 4.31e-01
DNA Damage Bypass 42 1.29e-01 -0.136000 2.64e-01
Programmed Cell Death 155 3.79e-03 -0.135000 2.16e-02
DNA Replication Pre-Initiation 90 2.70e-02 -0.135000 8.82e-02
Class I MHC mediated antigen processing & presentation 289 8.52e-05 -0.135000 1.68e-03
Class I peroxisomal membrane protein import 19 3.09e-01 -0.135000 4.86e-01
TNFR2 non-canonical NF-kB pathway 68 5.58e-02 -0.134000 1.52e-01
G alpha (i) signalling events 93 2.57e-02 0.134000 8.68e-02
Interferon gamma signaling 55 8.60e-02 -0.134000 2.03e-01
VxPx cargo-targeting to cilium 16 3.55e-01 -0.134000 5.32e-01
Cellular responses to stress 546 1.28e-07 -0.133000 8.54e-06
Caspase-mediated cleavage of cytoskeletal proteins 10 4.65e-01 0.133000 6.34e-01
Activation of BAD and translocation to mitochondria 14 3.89e-01 -0.133000 5.65e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 61 7.43e-02 -0.132000 1.85e-01
TCF dependent signaling in response to WNT 119 1.31e-02 -0.132000 5.19e-02
Metabolism of proteins 1246 2.19e-14 -0.132000 8.76e-12
Signaling by cytosolic FGFR1 fusion mutants 16 3.61e-01 -0.132000 5.39e-01
HSF1 activation 21 2.96e-01 -0.132000 4.70e-01
SARS-CoV Infections 270 2.16e-04 -0.131000 3.47e-03
Metabolism of steroids 86 3.57e-02 -0.131000 1.10e-01
ER to Golgi Anterograde Transport 108 1.90e-02 -0.131000 6.84e-02
RHOG GTPase cycle 49 1.15e-01 0.130000 2.42e-01
Fatty acid metabolism 104 2.21e-02 -0.130000 7.60e-02
ER Quality Control Compartment (ERQC) 18 3.41e-01 0.130000 5.23e-01
SARS-CoV-2 modulates host translation machinery 39 1.61e-01 -0.130000 3.06e-01
Gene expression (Transcription) 1040 5.14e-12 -0.129000 1.24e-09
Diseases of glycosylation 69 6.56e-02 -0.128000 1.68e-01
Death Receptor Signalling 96 3.12e-02 -0.127000 9.95e-02
Toll Like Receptor 3 (TLR3) Cascade 74 5.89e-02 -0.127000 1.57e-01
Deadenylation-dependent mRNA decay 52 1.13e-01 -0.127000 2.41e-01
Epigenetic regulation of gene expression 76 5.60e-02 -0.127000 1.52e-01
NOTCH1 Intracellular Domain Regulates Transcription 37 1.82e-01 -0.127000 3.33e-01
Signaling by WNT in cancer 23 2.93e-01 -0.127000 4.66e-01
Collagen biosynthesis and modifying enzymes 19 3.39e-01 0.127000 5.22e-01
SUMOylation of RNA binding proteins 42 1.57e-01 -0.126000 3.02e-01
Ras activation upon Ca2+ influx through NMDA receptor 10 4.90e-01 0.126000 6.57e-01
MyD88 dependent cascade initiated on endosome 67 7.50e-02 -0.126000 1.85e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 67 7.50e-02 -0.126000 1.85e-01
Interleukin-12 signaling 36 1.92e-01 -0.126000 3.44e-01
Asparagine N-linked glycosylation 225 1.20e-03 -0.126000 1.03e-02
Meiotic synapsis 25 2.77e-01 -0.126000 4.52e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 4.76e-01 -0.124000 6.46e-01
MyD88 cascade initiated on plasma membrane 65 8.46e-02 -0.124000 2.03e-01
Toll Like Receptor 10 (TLR10) Cascade 65 8.46e-02 -0.124000 2.03e-01
Toll Like Receptor 5 (TLR5) Cascade 65 8.46e-02 -0.124000 2.03e-01
Transport to the Golgi and subsequent modification 130 1.51e-02 -0.124000 5.75e-02
Regulation of beta-cell development 16 3.92e-01 -0.124000 5.67e-01
FCGR3A-mediated IL10 synthesis 22 3.16e-01 -0.123000 4.95e-01
Assembly of collagen fibrils and other multimeric structures 14 4.25e-01 0.123000 5.91e-01
Thromboxane signalling through TP receptor 15 4.10e-01 0.123000 5.81e-01
Mitophagy 25 2.91e-01 -0.122000 4.65e-01
Recycling pathway of L1 15 4.13e-01 -0.122000 5.84e-01
Interferon Signaling 142 1.25e-02 -0.122000 5.09e-02
Signaling by ALK fusions and activated point mutants 46 1.56e-01 -0.121000 3.00e-01
Signaling by ALK in cancer 46 1.56e-01 -0.121000 3.00e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 4.50e-01 -0.121000 6.19e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 4.17e-01 -0.121000 5.85e-01
Generic Transcription Pathway 826 6.34e-09 -0.121000 6.35e-07
Inactivation, recovery and regulation of the phototransduction cascade 17 3.89e-01 0.121000 5.65e-01
Signaling by ERBB4 31 2.46e-01 -0.120000 4.13e-01
Nuclear Events (kinase and transcription factor activation) 42 1.77e-01 -0.120000 3.25e-01
Mitochondrial translation 89 5.07e-02 -0.120000 1.40e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 27 2.82e-01 -0.120000 4.58e-01
Regulation of TP53 Activity through Acetylation 27 2.83e-01 -0.119000 4.59e-01
Cholesterol biosynthesis 22 3.33e-01 -0.119000 5.16e-01
Protein ubiquitination 59 1.14e-01 -0.119000 2.42e-01
RNA Polymerase II Transcription 927 1.71e-09 -0.119000 2.28e-07
Antigen processing: Ubiquitination & Proteasome degradation 241 1.58e-03 -0.119000 1.25e-02
G alpha (q) signalling events 78 7.07e-02 0.118000 1.77e-01
TICAM1, RIP1-mediated IKK complex recruitment 17 3.99e-01 -0.118000 5.73e-01
Activation of BH3-only proteins 27 2.88e-01 -0.118000 4.64e-01
Signaling by NODAL 12 4.79e-01 0.118000 6.47e-01
SUMO E3 ligases SUMOylate target proteins 132 1.95e-02 -0.118000 6.90e-02
Ion transport by P-type ATPases 27 2.89e-01 -0.118000 4.65e-01
RAS processing 15 4.30e-01 -0.118000 5.94e-01
Smooth Muscle Contraction 19 3.75e-01 -0.118000 5.51e-01
Interleukin-4 and Interleukin-13 signaling 49 1.55e-01 -0.118000 3.00e-01
Regulation of HSF1-mediated heat shock response 67 9.74e-02 -0.117000 2.22e-01
RAF activation 28 2.84e-01 -0.117000 4.59e-01
MET promotes cell motility 13 4.66e-01 -0.117000 6.35e-01
Fatty acyl-CoA biosynthesis 26 3.03e-01 -0.117000 4.80e-01
Platelet degranulation 49 1.59e-01 -0.116000 3.04e-01
RHOQ GTPase cycle 39 2.12e-01 0.116000 3.70e-01
EGFR downregulation 20 3.71e-01 -0.116000 5.46e-01
MAPK family signaling cascades 191 6.04e-03 -0.116000 2.99e-02
Post-translational protein modification 917 5.57e-09 -0.116000 6.09e-07
DAP12 interactions 21 3.60e-01 -0.116000 5.37e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 66 1.05e-01 -0.115000 2.31e-01
NoRC negatively regulates rRNA expression 42 1.98e-01 -0.115000 3.53e-01
Golgi Associated Vesicle Biogenesis 38 2.22e-01 -0.115000 3.82e-01
PLC beta mediated events 29 2.87e-01 -0.114000 4.63e-01
FCERI mediated MAPK activation 23 3.43e-01 0.114000 5.25e-01
Transcriptional Regulation by E2F6 29 2.91e-01 -0.113000 4.65e-01
Nuclear Envelope (NE) Reassembly 60 1.31e-01 -0.113000 2.68e-01
MAP2K and MAPK activation 25 3.30e-01 0.113000 5.12e-01
Mitochondrial translation termination 83 7.71e-02 -0.112000 1.88e-01
NCAM signaling for neurite out-growth 24 3.42e-01 0.112000 5.24e-01
MAPK1/MAPK3 signaling 164 1.36e-02 -0.112000 5.34e-02
Mitochondrial translation initiation 84 7.70e-02 -0.112000 1.88e-01
Signaling by NOTCH 135 2.58e-02 -0.111000 8.68e-02
Golgi Cisternae Pericentriolar Stack Reorganization 14 4.71e-01 -0.111000 6.40e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 22 3.70e-01 -0.111000 5.45e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 22 3.70e-01 -0.111000 5.45e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 22 3.70e-01 -0.111000 5.45e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 22 3.70e-01 -0.111000 5.45e-01
Impaired BRCA2 binding to PALB2 22 3.70e-01 -0.111000 5.45e-01
HDACs deacetylate histones 28 3.12e-01 -0.110000 4.91e-01
Response to elevated platelet cytosolic Ca2+ 53 1.69e-01 -0.109000 3.16e-01
SUMOylation 138 2.69e-02 -0.109000 8.82e-02
tRNA modification in the nucleus and cytosol 34 2.73e-01 -0.109000 4.48e-01
Vesicle-mediated transport 454 9.37e-05 -0.108000 1.82e-03
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 22 3.82e-01 -0.108000 5.58e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 12 5.19e-01 0.108000 6.83e-01
Unfolded Protein Response (UPR) 76 1.06e-01 -0.107000 2.32e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 14 4.87e-01 -0.107000 6.57e-01
STING mediated induction of host immune responses 10 5.58e-01 0.107000 7.13e-01
Oncogenic MAPK signaling 56 1.66e-01 -0.107000 3.13e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 29 3.21e-01 -0.107000 5.01e-01
Hyaluronan metabolism 11 5.41e-01 -0.106000 6.99e-01
Apoptotic factor-mediated response 16 4.62e-01 -0.106000 6.31e-01
RAC1 GTPase cycle 110 5.58e-02 0.106000 1.52e-01
SUMOylation of DNA damage response and repair proteins 67 1.36e-01 -0.106000 2.74e-01
Potential therapeutics for SARS 66 1.39e-01 -0.106000 2.78e-01
Cellular response to heat stress 80 1.03e-01 -0.105000 2.30e-01
Fc epsilon receptor (FCERI) signaling 107 6.00e-02 -0.105000 1.59e-01
GPCR downstream signalling 197 1.13e-02 0.105000 4.72e-02
Adrenaline,noradrenaline inhibits insulin secretion 15 4.81e-01 0.105000 6.50e-01
Signaling by NOTCH3 30 3.20e-01 -0.105000 5.01e-01
FGFR1 mutant receptor activation 20 4.18e-01 -0.105000 5.85e-01
Signaling by WNT 177 1.67e-02 -0.105000 6.24e-02
Regulation of signaling by CBL 14 4.99e-01 -0.104000 6.65e-01
Listeria monocytogenes entry into host cells 14 4.99e-01 -0.104000 6.65e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 3.08e-01 -0.104000 4.85e-01
G alpha (z) signalling events 25 3.69e-01 0.104000 5.45e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 14 5.02e-01 -0.104000 6.68e-01
SLC transporter disorders 52 1.98e-01 -0.103000 3.53e-01
Downregulation of ERBB2:ERBB3 signaling 10 5.74e-01 0.103000 7.17e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 5.07e-01 -0.103000 6.69e-01
Membrane Trafficking 446 2.35e-04 -0.102000 3.62e-03
Signaling by Hippo 12 5.39e-01 -0.102000 6.98e-01
Sialic acid metabolism 23 3.96e-01 -0.102000 5.70e-01
Deactivation of the beta-catenin transactivating complex 28 3.51e-01 -0.102000 5.31e-01
Signaling by NOTCH1 51 2.10e-01 -0.102000 3.68e-01
Inositol phosphate metabolism 30 3.38e-01 -0.101000 5.22e-01
Toll Like Receptor 9 (TLR9) Cascade 70 1.44e-01 -0.101000 2.87e-01
Transcriptional activation of mitochondrial biogenesis 40 2.70e-01 -0.101000 4.43e-01
FOXO-mediated transcription 46 2.40e-01 -0.100000 4.06e-01
SARS-CoV-1 Infection 46 2.42e-01 -0.099800 4.09e-01
RHOJ GTPase cycle 37 2.97e-01 0.099100 4.71e-01
Synthesis of substrates in N-glycan biosythesis 48 2.36e-01 -0.098900 4.02e-01
Toll-like Receptor Cascades 108 7.81e-02 -0.098300 1.90e-01
RET signaling 23 4.16e-01 -0.098100 5.85e-01
CDC42 GTPase cycle 97 9.59e-02 0.098000 2.19e-01
PI3K/AKT Signaling in Cancer 52 2.23e-01 -0.097800 3.82e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 35 3.17e-01 0.097800 4.96e-01
Regulation of innate immune responses to cytosolic DNA 12 5.59e-01 0.097400 7.13e-01
Diseases associated with the TLR signaling cascade 17 4.88e-01 -0.097100 6.57e-01
Diseases of Immune System 17 4.88e-01 -0.097100 6.57e-01
Aquaporin-mediated transport 25 4.06e-01 0.096000 5.78e-01
Collagen formation 28 3.82e-01 0.095500 5.58e-01
Formation of the beta-catenin:TCF transactivating complex 25 4.11e-01 -0.095000 5.81e-01
SUMOylation of transcription factors 13 5.53e-01 -0.095000 7.12e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 12 5.69e-01 0.095000 7.17e-01
Trafficking of AMPA receptors 12 5.69e-01 0.095000 7.17e-01
RHO GTPases Activate ROCKs 13 5.54e-01 0.094900 7.12e-01
Gastrin-CREB signalling pathway via PKC and MAPK 11 5.86e-01 -0.094800 7.28e-01
RAF/MAP kinase cascade 159 3.99e-02 -0.094700 1.18e-01
MTOR signalling 36 3.28e-01 -0.094200 5.11e-01
Signalling to RAS 12 5.72e-01 -0.094200 7.17e-01
Peptide hormone metabolism 31 3.65e-01 0.094000 5.44e-01
Beta-catenin independent WNT signaling 106 9.53e-02 -0.093900 2.19e-01
Interleukin receptor SHC signaling 15 5.30e-01 -0.093700 6.89e-01
Signaling by GPCR 216 1.84e-02 0.093400 6.78e-02
Sphingolipid metabolism 49 2.60e-01 -0.093200 4.31e-01
Assembly and cell surface presentation of NMDA receptors 13 5.62e-01 0.092900 7.13e-01
Mitochondrial translation elongation 84 1.44e-01 -0.092300 2.87e-01
Adaptive Immune System 481 6.27e-04 -0.091800 6.82e-03
HDMs demethylate histones 15 5.39e-01 -0.091700 6.98e-01
Heparan sulfate/heparin (HS-GAG) metabolism 22 4.60e-01 -0.091000 6.30e-01
GPVI-mediated activation cascade 23 4.50e-01 -0.091000 6.19e-01
Macroautophagy 97 1.22e-01 -0.090900 2.55e-01
G beta:gamma signalling through PLC beta 13 5.71e-01 0.090700 7.17e-01
Presynaptic function of Kainate receptors 13 5.71e-01 0.090700 7.17e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 10 6.21e-01 -0.090400 7.59e-01
Prolonged ERK activation events 13 5.74e-01 0.090100 7.17e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 16 5.35e-01 -0.089600 6.95e-01
Signaling by NTRK1 (TRKA) 79 1.71e-01 -0.089100 3.20e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 14 5.64e-01 -0.089100 7.14e-01
Intracellular signaling by second messengers 210 2.67e-02 -0.089000 8.78e-02
trans-Golgi Network Vesicle Budding 51 2.72e-01 -0.089000 4.46e-01
Fcgamma receptor (FCGR) dependent phagocytosis 62 2.26e-01 -0.088900 3.88e-01
PTEN Regulation 115 1.00e-01 -0.088900 2.26e-01
Signaling by Interleukins 265 1.38e-02 -0.088300 5.39e-02
Activation of kainate receptors upon glutamate binding 17 5.30e-01 0.088000 6.89e-01
Signaling by FGFR1 in disease 24 4.56e-01 -0.088000 6.24e-01
Mucopolysaccharidoses 10 6.35e-01 -0.086700 7.71e-01
Metabolism of steroid hormones 13 5.89e-01 -0.086600 7.29e-01
Glutamate Neurotransmitter Release Cycle 12 6.04e-01 0.086500 7.44e-01
RND1 GTPase cycle 29 4.22e-01 -0.086200 5.89e-01
Synthesis of PA 18 5.27e-01 0.086200 6.89e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 29 4.23e-01 -0.086100 5.89e-01
Signaling by NTRKs 87 1.68e-01 -0.085600 3.15e-01
Axon guidance 300 1.13e-02 -0.085500 4.72e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 71 2.14e-01 -0.085400 3.71e-01
Toll Like Receptor 2 (TLR2) Cascade 71 2.14e-01 -0.085400 3.71e-01
Toll Like Receptor TLR1:TLR2 Cascade 71 2.14e-01 -0.085400 3.71e-01
Toll Like Receptor TLR6:TLR2 Cascade 71 2.14e-01 -0.085400 3.71e-01
KSRP (KHSRP) binds and destabilizes mRNA 15 5.68e-01 -0.085100 7.17e-01
Autophagy 106 1.32e-01 -0.084900 2.69e-01
Extracellular matrix organization 93 1.61e-01 0.084300 3.06e-01
Cytokine Signaling in Immune system 427 3.20e-03 -0.083800 1.93e-02
O-linked glycosylation 42 3.48e-01 0.083800 5.28e-01
Nicotinamide salvaging 11 6.31e-01 0.083600 7.68e-01
Signaling by SCF-KIT 32 4.16e-01 -0.083000 5.85e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 39 3.74e-01 -0.082400 5.49e-01
Nervous system development 313 1.30e-02 -0.082100 5.19e-02
Intraflagellar transport 33 4.15e-01 -0.082000 5.85e-01
Synthesis of very long-chain fatty acyl-CoAs 16 5.71e-01 0.081900 7.17e-01
APC-Cdc20 mediated degradation of Nek2A 24 4.89e-01 -0.081600 6.57e-01
PIP3 activates AKT signaling 185 5.69e-02 -0.081400 1.53e-01
Nuclear signaling by ERBB4 16 5.73e-01 -0.081300 7.17e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 16 5.74e-01 0.081300 7.17e-01
Signaling by Receptor Tyrosine Kinases 293 1.73e-02 -0.081300 6.44e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 10 6.59e-01 -0.080700 7.92e-01
Metabolism of fat-soluble vitamins 13 6.15e-01 -0.080600 7.54e-01
RHOV GTPase cycle 28 4.62e-01 -0.080300 6.31e-01
RND2 GTPase cycle 34 4.20e-01 -0.080000 5.87e-01
NOTCH4 Intracellular Domain Regulates Transcription 14 6.04e-01 -0.080000 7.44e-01
Extra-nuclear estrogen signaling 49 3.33e-01 -0.079900 5.16e-01
Intra-Golgi traffic 39 3.88e-01 -0.079900 5.65e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 45 3.55e-01 -0.079700 5.32e-01
CaM pathway 20 5.40e-01 -0.079200 6.98e-01
Calmodulin induced events 20 5.40e-01 -0.079200 6.98e-01
TAK1-dependent IKK and NF-kappa-B activation 18 5.61e-01 -0.079200 7.13e-01
Senescence-Associated Secretory Phenotype (SASP) 42 3.77e-01 -0.078900 5.52e-01
Nonhomologous End-Joining (NHEJ) 29 4.63e-01 -0.078800 6.31e-01
Activation of NMDA receptors and postsynaptic events 44 3.66e-01 -0.078800 5.45e-01
Netrin-1 signaling 25 4.97e-01 0.078600 6.65e-01
Biological oxidations 79 2.28e-01 -0.078500 3.90e-01
Fanconi Anemia Pathway 31 4.51e-01 -0.078300 6.19e-01
Cellular Senescence 106 1.64e-01 -0.078300 3.11e-01
Pexophagy 11 6.53e-01 -0.078200 7.90e-01
Nuclear Envelope Breakdown 49 3.48e-01 -0.077600 5.28e-01
HSF1-dependent transactivation 25 5.03e-01 -0.077400 6.68e-01
Regulation of BACH1 activity 11 6.57e-01 -0.077400 7.91e-01
Signaling by TGF-beta Receptor Complex 72 2.58e-01 -0.077100 4.30e-01
Effects of PIP2 hydrolysis 19 5.61e-01 0.077000 7.13e-01
G alpha (12/13) signalling events 40 4.01e-01 0.076800 5.74e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 27 4.91e-01 -0.076600 6.58e-01
G beta:gamma signalling through CDC42 13 6.33e-01 0.076500 7.69e-01
Signaling by ERBB2 TMD/JMD mutants 10 6.75e-01 -0.076500 8.03e-01
RHOBTB GTPase Cycle 29 4.77e-01 -0.076400 6.46e-01
Chromatin modifying enzymes 158 1.00e-01 -0.076000 2.26e-01
Chromatin organization 158 1.00e-01 -0.076000 2.26e-01
Insulin receptor signalling cascade 26 5.06e-01 0.075400 6.69e-01
Iron uptake and transport 38 4.26e-01 -0.074700 5.91e-01
Josephin domain DUBs 11 6.68e-01 -0.074700 7.98e-01
Regulation of FZD by ubiquitination 12 6.58e-01 0.073900 7.91e-01
Activation of GABAB receptors 18 5.89e-01 0.073600 7.29e-01
GABA B receptor activation 18 5.89e-01 0.073600 7.29e-01
Ca-dependent events 21 5.59e-01 -0.073600 7.13e-01
VEGFA-VEGFR2 Pathway 71 2.84e-01 -0.073600 4.59e-01
Cytosolic sensors of pathogen-associated DNA 53 3.55e-01 -0.073500 5.32e-01
Apoptotic cleavage of cellular proteins 25 5.29e-01 0.072800 6.89e-01
Mitotic Prophase 75 2.76e-01 -0.072800 4.51e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 5.84e-01 -0.072500 7.26e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 5.84e-01 -0.072500 7.26e-01
EPH-Ephrin signaling 55 3.57e-01 -0.071900 5.34e-01
Post-translational protein phosphorylation 34 4.72e-01 0.071300 6.41e-01
Regulation of TP53 Expression and Degradation 34 4.77e-01 -0.070500 6.46e-01
PKA-mediated phosphorylation of CREB 11 6.86e-01 -0.070300 8.13e-01
Amino acid transport across the plasma membrane 16 6.27e-01 -0.070200 7.64e-01
SUMOylation of chromatin organization proteins 49 3.96e-01 -0.070200 5.70e-01
RHOBTB2 GTPase cycle 20 5.90e-01 -0.069500 7.29e-01
TCR signaling 87 2.66e-01 -0.069100 4.39e-01
EPHB-mediated forward signaling 25 5.53e-01 -0.068500 7.12e-01
Attenuation phase 19 6.06e-01 -0.068300 7.45e-01
Signaling by ERBB2 in Cancer 13 6.71e-01 -0.068100 7.98e-01
Mitochondrial calcium ion transport 19 6.07e-01 -0.068100 7.46e-01
Membrane binding and targetting of GAG proteins 12 6.84e-01 -0.067900 8.11e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 6.84e-01 -0.067900 8.11e-01
Uptake and actions of bacterial toxins 18 6.18e-01 -0.067800 7.57e-01
Developmental Biology 468 1.29e-02 -0.067700 5.15e-02
Regulation of TP53 Degradation 33 5.07e-01 -0.066800 6.69e-01
PKA activation 10 7.15e-01 -0.066600 8.27e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 26 5.57e-01 -0.066600 7.13e-01
Transport of small molecules 359 3.13e-02 -0.066600 9.96e-02
NGF-stimulated transcription 25 5.65e-01 -0.066500 7.14e-01
G alpha (s) signalling events 48 4.27e-01 0.066300 5.91e-01
Oncogene Induced Senescence 30 5.30e-01 -0.066300 6.89e-01
Metabolism of lipids 439 1.89e-02 -0.065900 6.82e-02
Platelet homeostasis 49 4.25e-01 -0.065900 5.91e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 27 5.57e-01 -0.065300 7.13e-01
Signaling by VEGF 73 3.36e-01 -0.065100 5.20e-01
Deadenylation of mRNA 23 5.90e-01 -0.064900 7.29e-01
APC/C:Cdc20 mediated degradation of Cyclin B 22 5.99e-01 -0.064800 7.38e-01
Signaling by BMP 15 6.64e-01 0.064700 7.96e-01
Signaling by Non-Receptor Tyrosine Kinases 36 5.04e-01 -0.064300 6.68e-01
Signaling by PTK6 36 5.04e-01 -0.064300 6.68e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 33 5.27e-01 0.063600 6.89e-01
Cell surface interactions at the vascular wall 56 4.17e-01 0.062700 5.85e-01
L1CAM interactions 41 4.89e-01 -0.062500 6.57e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 29 5.61e-01 -0.062300 7.13e-01
Signaling by RAS mutants 29 5.61e-01 -0.062300 7.13e-01
Signaling by moderate kinase activity BRAF mutants 29 5.61e-01 -0.062300 7.13e-01
Signaling downstream of RAS mutants 29 5.61e-01 -0.062300 7.13e-01
Signal transduction by L1 11 7.21e-01 0.062100 8.30e-01
Transcriptional regulation of white adipocyte differentiation 56 4.22e-01 -0.062000 5.89e-01
DCC mediated attractive signaling 11 7.22e-01 0.062000 8.30e-01
Glycosaminoglycan metabolism 64 3.92e-01 -0.061900 5.67e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 31 5.53e-01 0.061500 7.12e-01
Signal Transduction 1356 2.32e-04 -0.061300 3.62e-03
Transferrin endocytosis and recycling 19 6.46e-01 -0.060900 7.83e-01
Cytochrome P450 - arranged by substrate type 14 6.95e-01 0.060500 8.20e-01
Innate Immune System 620 1.17e-02 -0.060000 4.83e-02
Signaling by Erythropoietin 19 6.55e-01 -0.059200 7.90e-01
Activated NOTCH1 Transmits Signal to the Nucleus 19 6.57e-01 -0.058900 7.91e-01
NOD1/2 Signaling Pathway 23 6.26e-01 0.058700 7.64e-01
Costimulation by the CD28 family 44 5.02e-01 -0.058500 6.68e-01
XBP1(S) activates chaperone genes 42 5.13e-01 -0.058400 6.76e-01
Pyroptosis 18 6.69e-01 -0.058200 7.98e-01
activated TAK1 mediates p38 MAPK activation 13 7.17e-01 0.058000 8.27e-01
RHOA GTPase cycle 93 3.35e-01 0.058000 5.18e-01
Immune System 1156 1.44e-03 -0.056900 1.20e-02
Signaling by BRAF and RAF1 fusions 42 5.25e-01 -0.056800 6.88e-01
Rab regulation of trafficking 94 3.44e-01 -0.056600 5.25e-01
Other interleukin signaling 15 7.08e-01 -0.055900 8.24e-01
Integrin signaling 16 7.00e-01 -0.055700 8.21e-01
Platelet Aggregation (Plug Formation) 16 7.00e-01 -0.055700 8.21e-01
Visual phototransduction 34 5.75e-01 0.055600 7.17e-01
Signaling by ERBB2 33 5.81e-01 -0.055500 7.24e-01
IRE1alpha activates chaperones 43 5.30e-01 -0.055400 6.89e-01
MAPK targets/ Nuclear events mediated by MAP kinases 23 6.49e-01 -0.054900 7.85e-01
Metal ion SLC transporters 16 7.06e-01 -0.054400 8.24e-01
Post NMDA receptor activation events 38 5.63e-01 -0.054300 7.13e-01
ADP signalling through P2Y purinoceptor 12 13 7.35e-01 0.054200 8.33e-01
RUNX2 regulates osteoblast differentiation 13 7.38e-01 0.053600 8.35e-01
Anti-inflammatory response favouring Leishmania parasite infection 54 4.99e-01 -0.053300 6.65e-01
Leishmania parasite growth and survival 54 4.99e-01 -0.053300 6.65e-01
Signaling by TGFB family members 85 3.98e-01 -0.053200 5.72e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 449 5.72e-02 -0.052800 1.53e-01
Pre-NOTCH Processing in Golgi 16 7.17e-01 -0.052400 8.27e-01
Insulin processing 17 7.09e-01 -0.052200 8.26e-01
Detoxification of Reactive Oxygen Species 23 6.68e-01 -0.051700 7.98e-01
Clathrin-mediated endocytosis 89 4.04e-01 -0.051200 5.76e-01
mRNA decay by 3’ to 5’ exoribonuclease 14 7.41e-01 -0.051000 8.38e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 19 7.07e-01 -0.049900 8.24e-01
Stimuli-sensing channels 39 5.91e-01 0.049800 7.29e-01
Transport of vitamins, nucleosides, and related molecules 21 6.93e-01 -0.049800 8.18e-01
Signaling by Rho GTPases 437 7.90e-02 -0.049400 1.92e-01
Glucagon-type ligand receptors 14 7.56e-01 0.048000 8.47e-01
G beta:gamma signalling through PI3Kgamma 17 7.33e-01 0.047800 8.33e-01
Cargo recognition for clathrin-mediated endocytosis 63 5.13e-01 -0.047700 6.76e-01
Integration of energy metabolism 60 5.28e-01 -0.047100 6.89e-01
Negative regulation of FGFR1 signaling 18 7.33e-01 0.046500 8.33e-01
Negative regulation of FGFR2 signaling 18 7.33e-01 0.046500 8.33e-01
Negative regulation of FGFR3 signaling 18 7.33e-01 0.046500 8.33e-01
Negative regulation of FGFR4 signaling 18 7.33e-01 0.046500 8.33e-01
rRNA modification in the nucleus and cytosol 49 5.78e-01 -0.045900 7.21e-01
VEGFR2 mediated vascular permeability 21 7.17e-01 -0.045700 8.27e-01
IGF1R signaling cascade 23 7.05e-01 -0.045600 8.24e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 23 7.05e-01 -0.045600 8.24e-01
Insulin receptor recycling 17 7.47e-01 -0.045200 8.42e-01
Pre-NOTCH Transcription and Translation 31 6.64e-01 -0.045100 7.96e-01
IRS-related events triggered by IGF1R 22 7.16e-01 -0.044800 8.27e-01
NR1H2 and NR1H3-mediated signaling 27 6.88e-01 -0.044600 8.14e-01
Vasopressin regulates renal water homeostasis via Aquaporins 23 7.15e-01 0.044000 8.27e-01
Downregulation of TGF-beta receptor signaling 26 7.00e-01 -0.043700 8.21e-01
RUNX2 regulates bone development 18 7.50e-01 0.043400 8.44e-01
Glycerophospholipid biosynthesis 74 5.21e-01 -0.043200 6.85e-01
Amyloid fiber formation 27 6.98e-01 -0.043100 8.21e-01
RAB geranylgeranylation 40 6.38e-01 0.043000 7.74e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 7.52e-01 -0.043000 8.45e-01
Hemostasis 304 2.02e-01 -0.042800 3.57e-01
Nicotinate metabolism 19 7.48e-01 0.042600 8.42e-01
Regulation of IFNG signaling 13 7.91e-01 -0.042400 8.78e-01
Transport of bile salts and organic acids, metal ions and amine compounds 34 6.70e-01 0.042300 7.98e-01
Phase I - Functionalization of compounds 30 6.89e-01 0.042200 8.14e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 24 7.21e-01 0.042100 8.30e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 15 7.79e-01 -0.041900 8.69e-01
Infection with Mycobacterium tuberculosis 22 7.34e-01 0.041900 8.33e-01
DARPP-32 events 21 7.42e-01 -0.041600 8.38e-01
Neuronal System 139 3.99e-01 0.041500 5.73e-01
COPII-mediated vesicle transport 51 6.12e-01 -0.041100 7.50e-01
Sensory processing of sound 27 7.12e-01 0.041000 8.27e-01
Sensory processing of sound by inner hair cells of the cochlea 27 7.12e-01 0.041000 8.27e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 14 7.92e-01 0.040700 8.78e-01
Suppression of phagosomal maturation 12 8.10e-01 0.040200 8.89e-01
GABA receptor activation 19 7.64e-01 0.039800 8.55e-01
mTORC1-mediated signalling 21 7.53e-01 0.039700 8.45e-01
RHO GTPases Activate NADPH Oxidases 14 7.97e-01 0.039700 8.81e-01
NOTCH3 Intracellular Domain Regulates Transcription 15 7.91e-01 -0.039500 8.78e-01
PPARA activates gene expression 82 5.39e-01 -0.039300 6.98e-01
GPER1 signaling 25 7.34e-01 0.039200 8.33e-01
Protein methylation 14 8.01e-01 0.038800 8.85e-01
The role of Nef in HIV-1 replication and disease pathogenesis 19 7.71e-01 0.038600 8.61e-01
Telomere Extension By Telomerase 20 7.66e-01 -0.038400 8.57e-01
Neutrophil degranulation 307 2.50e-01 -0.038400 4.19e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 23 7.54e-01 0.037800 8.45e-01
E2F mediated regulation of DNA replication 19 7.79e-01 0.037200 8.69e-01
Interleukin-10 signaling 13 8.17e-01 -0.037100 8.94e-01
Regulation of lipid metabolism by PPARalpha 84 5.58e-01 -0.037000 7.13e-01
Negative regulation of FLT3 13 8.18e-01 0.037000 8.94e-01
RHO GTPases Activate WASPs and WAVEs 29 7.31e-01 -0.036900 8.33e-01
TP53 Regulates Transcription of Cell Death Genes 31 7.25e-01 0.036600 8.31e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 7.42e-01 0.036500 8.38e-01
Caspase activation via extrinsic apoptotic signalling pathway 15 8.07e-01 -0.036500 8.87e-01
Amino acids regulate mTORC1 42 6.96e-01 -0.034800 8.20e-01
Negative regulation of the PI3K/AKT network 56 6.54e-01 -0.034700 7.90e-01
Muscle contraction 67 6.24e-01 -0.034600 7.63e-01
Transcriptional Regulation by VENTX 30 7.44e-01 0.034500 8.39e-01
Phosphorylation of the APC/C 18 8.03e-01 -0.034000 8.85e-01
Cardiac conduction 43 7.06e-01 0.033300 8.24e-01
Pre-NOTCH Expression and Processing 46 6.97e-01 -0.033200 8.21e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 16 8.20e-01 -0.032800 8.96e-01
Opioid Signalling 58 6.69e-01 -0.032500 7.98e-01
Platelet activation, signaling and aggregation 132 5.21e-01 -0.032500 6.85e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 23 7.90e-01 0.032200 8.78e-01
Retinoid metabolism and transport 11 8.53e-01 -0.032200 9.22e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 8.18e-01 -0.031400 8.94e-01
RAB GEFs exchange GTP for GDP on RABs 64 6.67e-01 0.031100 7.98e-01
Ca2+ pathway 40 7.34e-01 -0.031000 8.33e-01
Sphingolipid de novo biosynthesis 22 8.01e-01 -0.031000 8.85e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 50 7.06e-01 -0.030800 8.24e-01
Synthesis of PIPs at the Golgi membrane 12 8.54e-01 0.030700 9.22e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 20 8.14e-01 -0.030400 8.92e-01
Signaling by high-kinase activity BRAF mutants 22 8.07e-01 0.030100 8.87e-01
Synthesis of PC 22 8.08e-01 -0.029900 8.88e-01
Synthesis of bile acids and bile salts 13 8.52e-01 -0.029900 9.22e-01
MAP kinase activation 49 7.19e-01 -0.029700 8.29e-01
Cell-Cell communication 48 7.26e-01 0.029300 8.31e-01
RHOC GTPase cycle 49 7.24e-01 0.029200 8.31e-01
Sensory Perception 68 6.79e-01 0.029100 8.06e-01
Transmission across Chemical Synapses 101 6.27e-01 0.028000 7.64e-01
FLT3 Signaling 32 7.84e-01 -0.028000 8.73e-01
Signaling by Leptin 10 8.79e-01 0.027800 9.36e-01
Class B/2 (Secretin family receptors) 29 7.96e-01 0.027700 8.81e-01
Downregulation of ERBB2 signaling 17 8.47e-01 0.027000 9.20e-01
NRAGE signals death through JNK 30 8.07e-01 -0.025800 8.87e-01
Growth hormone receptor signaling 17 8.54e-01 0.025700 9.22e-01
Myogenesis 13 8.73e-01 0.025600 9.36e-01
DAP12 signaling 19 8.48e-01 -0.025400 9.21e-01
Signalling to ERKs 25 8.26e-01 -0.025400 9.01e-01
Inflammasomes 16 8.62e-01 -0.025100 9.28e-01
Late endosomal microautophagy 23 8.41e-01 -0.024200 9.16e-01
Signaling by RAF1 mutants 25 8.40e-01 0.023300 9.16e-01
Regulation of actin dynamics for phagocytic cup formation 44 7.94e-01 -0.022800 8.79e-01
Transcriptional regulation of granulopoiesis 25 8.44e-01 0.022700 9.19e-01
Response of Mtb to phagocytosis 20 8.64e-01 0.022200 9.29e-01
Ion channel transport 80 7.32e-01 -0.022100 8.33e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 16 8.78e-01 0.022100 9.36e-01
Syndecan interactions 10 9.06e-01 0.021600 9.56e-01
Zinc transporters 12 9.00e-01 0.020900 9.52e-01
Sensory processing of sound by outer hair cells of the cochlea 18 8.80e-01 0.020500 9.36e-01
Chondroitin sulfate/dermatan sulfate metabolism 27 8.56e-01 0.020200 9.23e-01
SLC-mediated transmembrane transport 105 7.26e-01 -0.019900 8.31e-01
The NLRP3 inflammasome 12 9.06e-01 0.019700 9.56e-01
Maturation of nucleoprotein 11 9.10e-01 -0.019700 9.58e-01
RHOB GTPase cycle 44 8.26e-01 -0.019200 9.01e-01
Calnexin/calreticulin cycle 23 8.74e-01 -0.019100 9.36e-01
Carboxyterminal post-translational modifications of tubulin 24 8.74e-01 -0.018700 9.36e-01
Metalloprotease DUBs 17 8.94e-01 -0.018600 9.50e-01
ADORA2B mediated anti-inflammatory cytokines production 33 8.54e-01 -0.018500 9.22e-01
SUMOylation of transcription cofactors 35 8.50e-01 -0.018500 9.22e-01
Regulation of MECP2 expression and activity 23 8.78e-01 0.018500 9.36e-01
Phospholipid metabolism 133 7.17e-01 -0.018200 8.27e-01
Activation of the pre-replicative complex 30 8.66e-01 -0.017900 9.31e-01
Integrin cell surface interactions 25 8.80e-01 -0.017500 9.36e-01
Signaling by FGFR3 26 8.79e-01 0.017200 9.36e-01
RND3 GTPase cycle 29 8.73e-01 0.017200 9.36e-01
Signal amplification 20 8.96e-01 0.016900 9.50e-01
PI3K Cascade 19 9.00e-01 -0.016600 9.52e-01
Signaling by Insulin receptor 42 8.55e-01 0.016300 9.22e-01
Basigin interactions 14 9.20e-01 0.015500 9.64e-01
Regulation of insulin secretion 40 8.68e-01 0.015200 9.32e-01
Signaling by FGFR1 28 8.90e-01 0.015100 9.46e-01
Leishmania infection 112 7.83e-01 -0.015100 8.72e-01
RHO GTPase cycle 294 6.61e-01 0.015000 7.93e-01
Neurexins and neuroligins 21 9.06e-01 -0.014800 9.56e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 11 9.34e-01 0.014500 9.71e-01
CD209 (DC-SIGN) signaling 15 9.23e-01 -0.014400 9.66e-01
Neurotransmitter release cycle 20 9.12e-01 -0.014200 9.59e-01
Cytochrome c-mediated apoptotic response 11 9.36e-01 -0.014100 9.71e-01
Cell recruitment (pro-inflammatory response) 15 9.28e-01 0.013500 9.69e-01
Purinergic signaling in leishmaniasis infection 15 9.28e-01 0.013500 9.69e-01
RHOU GTPase cycle 32 8.98e-01 -0.013100 9.51e-01
FOXO-mediated transcription of cell cycle genes 13 9.35e-01 -0.013000 9.71e-01
Termination of O-glycan biosynthesis 10 9.45e-01 -0.012500 9.75e-01
FCERI mediated Ca+2 mobilization 23 9.18e-01 -0.012400 9.63e-01
Spry regulation of FGF signaling 15 9.34e-01 0.012400 9.71e-01
Oxidative Stress Induced Senescence 55 8.76e-01 0.012100 9.36e-01
IRS-mediated signalling 21 9.23e-01 -0.012100 9.66e-01
Constitutive Signaling by Aberrant PI3K in Cancer 28 9.12e-01 -0.012000 9.59e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 14 9.39e-01 -0.011800 9.74e-01
Protein-protein interactions at synapses 33 9.08e-01 -0.011600 9.57e-01
Glucagon signaling in metabolic regulation 18 9.33e-01 0.011400 9.71e-01
Assembly Of The HIV Virion 14 9.44e-01 -0.010800 9.75e-01
Processing of SMDT1 13 9.47e-01 -0.010700 9.75e-01
RHOBTB1 GTPase cycle 18 9.42e-01 -0.009980 9.75e-01
PI Metabolism 60 8.97e-01 0.009630 9.51e-01
Transcriptional Regulation by MECP2 31 9.33e-01 -0.008760 9.71e-01
Ephrin signaling 12 9.58e-01 -0.008680 9.84e-01
ROS and RNS production in phagocytes 23 9.45e-01 -0.008330 9.75e-01
Interleukin-37 signaling 17 9.53e-01 0.008250 9.80e-01
Lysosome Vesicle Biogenesis 24 9.44e-01 0.008220 9.75e-01
Interconversion of nucleotide di- and triphosphates 25 9.47e-01 -0.007650 9.75e-01
Regulation of PTEN gene transcription 48 9.31e-01 0.007240 9.71e-01
Metabolic disorders of biological oxidation enzymes 14 9.63e-01 -0.007200 9.87e-01
Degradation of the extracellular matrix 35 9.42e-01 -0.007120 9.75e-01
O-linked glycosylation of mucins 26 9.56e-01 0.006250 9.82e-01
TGF-beta receptor signaling activates SMADs 39 9.47e-01 0.006110 9.75e-01
Bile acid and bile salt metabolism 15 9.69e-01 -0.005830 9.91e-01
Regulation of TP53 Activity through Methylation 17 9.68e-01 0.005660 9.91e-01
Transcriptional regulation by RUNX1 137 9.15e-01 -0.005320 9.60e-01
Interleukin-2 family signaling 28 9.65e-01 -0.004740 9.89e-01
Budding and maturation of HIV virion 24 9.71e-01 0.004240 9.93e-01
Cytosolic sulfonation of small molecules 10 9.83e-01 -0.003930 9.96e-01
Initiation of Nuclear Envelope (NE) Reformation 17 9.82e-01 -0.003220 9.96e-01
Dopamine Neurotransmitter Release Cycle 12 9.85e-01 0.003180 9.96e-01
Synthesis of PIPs at the plasma membrane 36 9.74e-01 -0.003160 9.95e-01
Apoptotic execution phase 33 9.75e-01 0.003120 9.95e-01
Plasma lipoprotein remodeling 11 9.86e-01 0.003080 9.96e-01
Signaling by FGFR4 25 9.79e-01 -0.003070 9.96e-01
CTLA4 inhibitory signaling 16 9.83e-01 -0.003030 9.96e-01
Regulation of RUNX1 Expression and Activity 17 9.83e-01 0.002960 9.96e-01
A tetrasaccharide linker sequence is required for GAG synthesis 10 9.87e-01 0.002900 9.96e-01
Synthesis of PIPs at the early endosome membrane 12 9.90e-01 -0.002150 9.96e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 38 9.83e-01 0.002010 9.96e-01
Regulation of KIT signaling 10 9.92e-01 0.001890 9.96e-01
G-protein beta:gamma signalling 21 9.89e-01 -0.001760 9.96e-01
Neurotransmitter receptors and postsynaptic signal transmission 77 9.80e-01 -0.001670 9.96e-01
Cargo concentration in the ER 20 9.90e-01 -0.001640 9.96e-01
Nuclear events stimulated by ALK signaling in cancer 14 9.93e-01 0.001450 9.96e-01
Negative regulation of MET activity 16 9.93e-01 -0.001270 9.96e-01
Erythropoietin activates RAS 10 9.95e-01 -0.001240 9.96e-01
RHO GTPases activate PAKs 13 9.94e-01 -0.001190 9.96e-01
Gap junction trafficking 10 9.95e-01 0.001170 9.96e-01
FCGR3A-mediated phagocytosis 42 9.92e-01 0.000893 9.96e-01
Leishmania phagocytosis 42 9.92e-01 0.000893 9.96e-01
Parasite infection 42 9.92e-01 0.000893 9.96e-01
Interleukin-17 signaling 52 9.92e-01 0.000825 9.96e-01
Gap junction trafficking and regulation 11 9.98e-01 -0.000379 9.98e-01


Detailed Gene set reports



Signaling by FGFR2 IIIa TM

Signaling by FGFR2 IIIa TM
971
set Signaling by FGFR2 IIIa TM
setSize 15
pANOVA 8.17e-05
s.dist -0.587
p.adjustANOVA 0.00164



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11217.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
NCBP2 -9159.0
POLR2C -9154.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
POLR2E -6115.0
POLR2G -4537.0
POLR2K -2543.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11217.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
NCBP2 -9159.0
POLR2C -9154.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
POLR2E -6115.0
POLR2G -4537.0
POLR2K -2543.0


TNFs bind their physiological receptors

TNFs bind their physiological receptors
1066
set TNFs bind their physiological receptors
setSize 10
pANOVA 0.00867
s.dist 0.479
p.adjustANOVA 0.0393



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNFRSF25 0.5
TNFSF14 0.5
TNFSF13 -712.5
CD27 -911.0
TNFRSF1B -1094.0
EDARADD -1156.0
LTA -2247.0
TNFSF9 -4935.0
TNFSF13B -6064.0
TNFRSF1A -6418.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNFRSF25 0.5
TNFSF14 0.5
TNFSF13 -712.5
CD27 -911.0
TNFRSF1B -1094.0
EDARADD -1156.0
LTA -2247.0
TNFSF9 -4935.0
TNFSF13B -6064.0
TNFRSF1A -6418.0


FGFR2 mutant receptor activation

FGFR2 mutant receptor activation
309
set FGFR2 mutant receptor activation
setSize 17
pANOVA 0.00063
s.dist -0.479
p.adjustANOVA 0.00682



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11217.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
NCBP2 -9159.0
POLR2C -9154.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
FGF9 -6430.0
POLR2E -6115.0
POLR2G -4537.0
POLR2K -2543.0
FGF8 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11217.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
NCBP2 -9159.0
POLR2C -9154.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
FGF9 -6430.0
POLR2E -6115.0
POLR2G -4537.0
POLR2K -2543.0
FGF8 0.5


Inhibition of DNA recombination at telomere

Inhibition of DNA recombination at telomere
448
set Inhibition of DNA recombination at telomere
setSize 18
pANOVA 0.000497
s.dist -0.474
p.adjustANOVA 0.00563



Top enriched genes

Top 20 genes
GeneID Gene Rank
TERF2IP -10889.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
POLR2C -9154.0
DAXX -9029.0
POLR2H -8695.0
POLR2I -8128.5
H2AFX -7718.0
TINF2 -7694.0
ACD -7545.5
POLR2E -6115.0
TERF1 -5347.0
TERF2 -4556.0
POLR2G -4537.0
POLR2K -2543.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TERF2IP -10889.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
POLR2C -9154.0
DAXX -9029.0
POLR2H -8695.0
POLR2I -8128.5
H2AFX -7718.0
TINF2 -7694.0
ACD -7545.5
POLR2E -6115.0
TERF1 -5347.0
TERF2 -4556.0
POLR2G -4537.0
POLR2K -2543.0


SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
908
set SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize 10
pANOVA 0.0188
s.dist -0.429
p.adjustANOVA 0.068



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11217.5
SNRPG -10447.0
LSM10 -9356.0
LSM11 -9277.0
NCBP2 -9159.0
SNRPD3 -8824.0
ZNF473 -7696.5
SLBP -6794.0
SNRPE -3938.0
SNRPB -1335.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11217.5
SNRPG -10447.0
LSM10 -9356.0
LSM11 -9277.0
NCBP2 -9159.0
SNRPD3 -8824.0
ZNF473 -7696.5
SLBP -6794.0
SNRPE -3938.0
SNRPB -1335.0


Signaling by FGFR2 in disease

Signaling by FGFR2 in disease
972
set Signaling by FGFR2 in disease
setSize 24
pANOVA 3e-04
s.dist -0.426
p.adjustANOVA 0.00413



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11217.5
GRB2 -10948.0
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
PIK3R1 -10030.0
GTF2F2 -9899.0
NCBP2 -9159.0
POLR2C -9154.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
PIK3CA -7112.0
FGF9 -6430.0
POLR2E -6115.0
PLCG1 -5578.0
HRAS -5505.0
FRS2 -5359.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11217.5
GRB2 -10948.0
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
PIK3R1 -10030.0
GTF2F2 -9899.0
NCBP2 -9159.0
POLR2C -9154.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
PIK3CA -7112.0
FGF9 -6430.0
POLR2E -6115.0
PLCG1 -5578.0
HRAS -5505.0
FRS2 -5359.0
KRAS -4584.0
POLR2G -4537.0
POLR2K -2543.0
FGF8 0.5


Synthesis of glycosylphosphatidylinositol (GPI)

Synthesis of glycosylphosphatidylinositol (GPI)
1050
set Synthesis of glycosylphosphatidylinositol (GPI)
setSize 14
pANOVA 0.00589
s.dist -0.425
p.adjustANOVA 0.0292



Top enriched genes

Top 20 genes
GeneID Gene Rank
PIGL -11036.0
PIGX -10404.0
PIGV -10285.0
PIGY -9835.0
PIGC -9543.5
PIGQ -9505.0
PIGP -9229.5
PIGM -7446.0
PIGO -7052.0
PIGF -5485.5
PIGN -5078.5
PIGW -4764.5
PIGH -4638.0
DPM2 -4608.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIGL -11036.0
PIGX -10404.0
PIGV -10285.0
PIGY -9835.0
PIGC -9543.5
PIGQ -9505.0
PIGP -9229.5
PIGM -7446.0
PIGO -7052.0
PIGF -5485.5
PIGN -5078.5
PIGW -4764.5
PIGH -4638.0
DPM2 -4608.0


Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs
731
set Processing of Intronless Pre-mRNAs
setSize 15
pANOVA 0.00445
s.dist -0.424
p.adjustANOVA 0.0241



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11217.5
SYMPK -10166.0
CPSF2 -10143.5
PAPOLA -9972.0
CLP1 -9822.0
CPSF4 -9362.5
NCBP2 -9159.0
CPSF1 -8799.0
FIP1L1 -8556.0
CPSF3 -7555.5
NUDT21 -6901.5
WDR33 -5938.0
CSTF1 -4789.5
CPSF6 -2584.0
PABPN1 -1636.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11217.5
SYMPK -10166.0
CPSF2 -10143.5
PAPOLA -9972.0
CLP1 -9822.0
CPSF4 -9362.5
NCBP2 -9159.0
CPSF1 -8799.0
FIP1L1 -8556.0
CPSF3 -7555.5
NUDT21 -6901.5
WDR33 -5938.0
CSTF1 -4789.5
CPSF6 -2584.0
PABPN1 -1636.0


Endosomal/Vacuolar pathway

Endosomal/Vacuolar pathway
287
set Endosomal/Vacuolar pathway
setSize 10
pANOVA 0.021
s.dist -0.421
p.adjustANOVA 0.0731



Top enriched genes

Top 20 genes
GeneID Gene Rank
HLA-E -11224
HLA-C -11092
HLA-B -11013
HLA-F -10786
HLA-H -9920
LNPEP -8241
HLA-A -7948
CTSL -4529
CTSV -1820
B2M -1009

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HLA-E -11224
HLA-C -11092
HLA-B -11013
HLA-F -10786
HLA-H -9920
LNPEP -8241
HLA-A -7948
CTSL -4529
CTSV -1820
B2M -1009


Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)
1042
set Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize 10
pANOVA 0.0245
s.dist 0.411
p.adjustANOVA 0.0835



Top enriched genes

Top 20 genes
GeneID Gene Rank
GGT1 0.5
CYP4F22 -1015.0
ALOX5AP -1742.0
LTA4H -2235.0
DPEP2 -2398.0
PTGR1 -2458.0
LTC4S -2632.0
MAPKAPK2 -2956.0
ALOX5 -4465.0
ABCC1 -7753.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GGT1 0.5
CYP4F22 -1015.0
ALOX5AP -1742.0
LTA4H -2235.0
DPEP2 -2398.0
PTGR1 -2458.0
LTC4S -2632.0
MAPKAPK2 -2956.0
ALOX5 -4465.0
ABCC1 -7753.0


FGFR2 alternative splicing

FGFR2 alternative splicing
308
set FGFR2 alternative splicing
setSize 22
pANOVA 0.000857
s.dist -0.411
p.adjustANOVA 0.00818



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11217.5
HNRNPF -11156.0
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
NCBP2 -9159.0
POLR2C -9154.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
TIAL1 -7519.0
TIA1 -6473.0
POLR2E -6115.0
POLR2G -4537.0
PTBP1 -3721.0
ESRP2 -3664.0
HNRNPH1 -3047.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11217.5
HNRNPF -11156.0
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
NCBP2 -9159.0
POLR2C -9154.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
TIAL1 -7519.0
TIA1 -6473.0
POLR2E -6115.0
POLR2G -4537.0
PTBP1 -3721.0
ESRP2 -3664.0
HNRNPH1 -3047.0
POLR2K -2543.0
HNRNPM -2327.0


alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
1178
set alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize 10
pANOVA 0.0261
s.dist -0.406
p.adjustANOVA 0.0871



Top enriched genes

Top 20 genes
GeneID Gene Rank
ELOVL1 -10536.0
FADS2 -10452.0
FADS1 -10436.0
ACOX1 -10303.0
ELOVL5 -8299.0
SCP2 -8189.0
ACAA1 -7457.0
ACOT8 -6367.5
ACSL1 -3587.0
HSD17B4 -1053.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ELOVL1 -10536.0
FADS2 -10452.0
FADS1 -10436.0
ACOX1 -10303.0
ELOVL5 -8299.0
SCP2 -8189.0
ACAA1 -7457.0
ACOT8 -6367.5
ACSL1 -3587.0
HSD17B4 -1053.0


alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism
1179
set alpha-linolenic acid (ALA) metabolism
setSize 10
pANOVA 0.0261
s.dist -0.406
p.adjustANOVA 0.0871



Top enriched genes

Top 20 genes
GeneID Gene Rank
ELOVL1 -10536.0
FADS2 -10452.0
FADS1 -10436.0
ACOX1 -10303.0
ELOVL5 -8299.0
SCP2 -8189.0
ACAA1 -7457.0
ACOT8 -6367.5
ACSL1 -3587.0
HSD17B4 -1053.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ELOVL1 -10536.0
FADS2 -10452.0
FADS1 -10436.0
ACOX1 -10303.0
ELOVL5 -8299.0
SCP2 -8189.0
ACAA1 -7457.0
ACOT8 -6367.5
ACSL1 -3587.0
HSD17B4 -1053.0


Metabolism of folate and pterines

Metabolism of folate and pterines
544
set Metabolism of folate and pterines
setSize 11
pANOVA 0.0209
s.dist -0.402
p.adjustANOVA 0.0731



Top enriched genes

Top 20 genes
GeneID Gene Rank
MTHFR -10981.0
DHFR -10184.5
SHMT2 -9071.0
MTHFD2 -8816.0
SLC19A1 -8391.0
MTHFS -7619.0
SLC25A32 -7220.5
SHMT1 -6777.0
MTHFD1 -6751.0
MTHFD1L -4549.0
FPGS -3714.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTHFR -10981.0
DHFR -10184.5
SHMT2 -9071.0
MTHFD2 -8816.0
SLC19A1 -8391.0
MTHFS -7619.0
SLC25A32 -7220.5
SHMT1 -6777.0
MTHFD1 -6751.0
MTHFD1L -4549.0
FPGS -3714.0


Purine ribonucleoside monophosphate biosynthesis

Purine ribonucleoside monophosphate biosynthesis
744
set Purine ribonucleoside monophosphate biosynthesis
setSize 10
pANOVA 0.0284
s.dist -0.4
p.adjustANOVA 0.0919



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATIC -10997.0
GMPS -8951.0
IMPDH2 -7785.0
IMPDH1 -7754.0
ADSL -7729.0
PFAS -7521.0
PAICS -7017.5
PPAT -7017.5
ADSS -6966.0
ADSSL1 -4578.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATIC -10997.0
GMPS -8951.0
IMPDH2 -7785.0
IMPDH1 -7754.0
ADSL -7729.0
PFAS -7521.0
PAICS -7017.5
PPAT -7017.5
ADSS -6966.0
ADSSL1 -4578.0


mRNA Capping

mRNA Capping
1181
set mRNA Capping
setSize 26
pANOVA 0.000447
s.dist -0.398
p.adjustANOVA 0.00526



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11217.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
RNMT -10652.0
GTF2H4 -10604.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
NCBP2 -9159.0
POLR2C -9154.0
SUPT5H -8924.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
ERCC2 -7286.0
CCNH -6561.0
POLR2E -6115.0
POLR2G -4537.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11217.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
RNMT -10652.0
GTF2H4 -10604.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
NCBP2 -9159.0
POLR2C -9154.0
SUPT5H -8924.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
ERCC2 -7286.0
CCNH -6561.0
POLR2E -6115.0
POLR2G -4537.0
GTF2H5 -4326.5
CDK7 -4043.0
POLR2K -2543.0
ERCC3 -1456.0
MNAT1 -1257.0
RNGTT -654.0


Purine salvage

Purine salvage
745
set Purine salvage
setSize 11
pANOVA 0.023
s.dist -0.396
p.adjustANOVA 0.0785



Top enriched genes

Top 20 genes
GeneID Gene Rank
ADAL -10739.5
GMPR2 -10628.5
ADK -10476.0
APRT -9577.0
AMPD2 -9492.0
DCK -8100.0
DGUOK -5774.0
AMPD3 -5648.0
GMPR -5241.0
PNP -4669.0
ADA -3308.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADAL -10739.5
GMPR2 -10628.5
ADK -10476.0
APRT -9577.0
AMPD2 -9492.0
DCK -8100.0
DGUOK -5774.0
AMPD3 -5648.0
GMPR -5241.0
PNP -4669.0
ADA -3308.0


Generation of second messenger molecules

Generation of second messenger molecules
374
set Generation of second messenger molecules
setSize 15
pANOVA 0.00825
s.dist 0.394
p.adjustANOVA 0.0382



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITK 664
LCP2 -727
ZAP70 -853
GRAP2 -880
PAK2 -934
EVL -1175
CD4 -1188
CD3E -1564
LCK -2008
CD247 -2822
PAK1 -3685
PLCG1 -5578
NCK1 -5778
VASP -7279
PLCG2 -9190

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITK 664
LCP2 -727
ZAP70 -853
GRAP2 -880
PAK2 -934
EVL -1175
CD4 -1188
CD3E -1564
LCK -2008
CD247 -2822
PAK1 -3685
PLCG1 -5578
NCK1 -5778
VASP -7279
PLCG2 -9190


Processing of Capped Intronless Pre-mRNA

Processing of Capped Intronless Pre-mRNA
729
set Processing of Capped Intronless Pre-mRNA
setSize 23
pANOVA 0.00115
s.dist -0.392
p.adjustANOVA 0.0101



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11217.5
SNRPG -10447.0
SYMPK -10166.0
CPSF2 -10143.5
PAPOLA -9972.0
CLP1 -9822.0
CPSF4 -9362.5
LSM10 -9356.0
LSM11 -9277.0
NCBP2 -9159.0
SNRPD3 -8824.0
CPSF1 -8799.0
FIP1L1 -8556.0
ZNF473 -7696.5
CPSF3 -7555.5
NUDT21 -6901.5
SLBP -6794.0
WDR33 -5938.0
CSTF1 -4789.5
SNRPE -3938.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11217.5
SNRPG -10447.0
SYMPK -10166.0
CPSF2 -10143.5
PAPOLA -9972.0
CLP1 -9822.0
CPSF4 -9362.5
LSM10 -9356.0
LSM11 -9277.0
NCBP2 -9159.0
SNRPD3 -8824.0
CPSF1 -8799.0
FIP1L1 -8556.0
ZNF473 -7696.5
CPSF3 -7555.5
NUDT21 -6901.5
SLBP -6794.0
WDR33 -5938.0
CSTF1 -4789.5
SNRPE -3938.0
CPSF6 -2584.0
PABPN1 -1636.0
SNRPB -1335.0


Abortive elongation of HIV-1 transcript in the absence of Tat

Abortive elongation of HIV-1 transcript in the absence of Tat
24
set Abortive elongation of HIV-1 transcript in the absence of Tat
setSize 22
pANOVA 0.00161
s.dist -0.388
p.adjustANOVA 0.0126



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -11217.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
SUPT4H1 -10680.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
CTDP1 -9455.0
NCBP2 -9159.0
POLR2C -9154.0
SUPT5H -8924.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
POLR2E -6115.0
POLR2G -4537.0
NELFA -3213.0
NELFB -2711.0
POLR2K -2543.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -11217.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
SUPT4H1 -10680.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
CTDP1 -9455.0
NCBP2 -9159.0
POLR2C -9154.0
SUPT5H -8924.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
POLR2E -6115.0
POLR2G -4537.0
NELFA -3213.0
NELFB -2711.0
POLR2K -2543.0
NELFCD 0.5
NELFE 0.5


Defects in vitamin and cofactor metabolism

Defects in vitamin and cofactor metabolism
217
set Defects in vitamin and cofactor metabolism
setSize 16
pANOVA 0.00716
s.dist -0.388
p.adjustANOVA 0.034



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCCC1 -11140.0
MMAB -11127.5
ACACA -10998.0
MTR -10761.0
MMACHC -9784.5
MMAA -9460.0
PCCB -8161.0
MTRR -6962.0
ABCD4 -6454.0
MCCC2 -6076.0
PC -5853.0
MMADHC -5605.0
BTD -5551.5
CD320 -5526.0
HLCS -4895.0
LMBRD1 -2583.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCCC1 -11140.0
MMAB -11127.5
ACACA -10998.0
MTR -10761.0
MMACHC -9784.5
MMAA -9460.0
PCCB -8161.0
MTRR -6962.0
ABCD4 -6454.0
MCCC2 -6076.0
PC -5853.0
MMADHC -5605.0
BTD -5551.5
CD320 -5526.0
HLCS -4895.0
LMBRD1 -2583.0


Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Antigen Presentation: Folding, assembly and peptide loading of class I MHC
51
set Antigen Presentation: Folding, assembly and peptide loading of class I MHC
setSize 26
pANOVA 0.000726
s.dist -0.383
p.adjustANOVA 0.0074



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAP1 -11233.0
HLA-E -11224.0
TAPBP -11214.0
HLA-C -11092.0
HLA-B -11013.0
HLA-F -10786.0
SEC24A -10670.0
SEC23A -10461.0
HLA-H -9920.0
SAR1B -9783.0
SEC24B -9634.0
ERAP1 -9625.0
SEC31A -9457.0
TAP2 -9314.0
CALR -9146.0
PDIA3 -8596.5
SEC13 -8417.0
BECN1 -8092.0
HLA-A -7948.0
CANX -4026.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAP1 -11233.0
HLA-E -11224.0
TAPBP -11214.0
HLA-C -11092.0
HLA-B -11013.0
HLA-F -10786.0
SEC24A -10670.0
SEC23A -10461.0
HLA-H -9920.0
SAR1B -9783.0
SEC24B -9634.0
ERAP1 -9625.0
SEC31A -9457.0
TAP2 -9314.0
CALR -9146.0
PDIA3 -8596.5
SEC13 -8417.0
BECN1 -8092.0
HLA-A -7948.0
CANX -4026.0
SEC24D -1119.0
SEC24C -1022.0
B2M -1009.0
PIK3R4 -830.0
ATG14 0.5
ERAP2 0.5


PIWI-interacting RNA (piRNA) biogenesis

PIWI-interacting RNA (piRNA) biogenesis
677
set PIWI-interacting RNA (piRNA) biogenesis
setSize 16
pANOVA 0.00971
s.dist -0.373
p.adjustANOVA 0.0426



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
HSP90AA1 -10186.0
POLR2C -9154.0
POLR2H -8695.0
POLR2I -8128.5
HENMT1 -6194.0
POLR2E -6115.0
TDRKH -5884.0
POLR2G -4537.0
MYBL1 -3422.0
POLR2K -2543.0
PLD6 -1292.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
POLR2F -10444.5
POLR2L -10350.5
HSP90AA1 -10186.0
POLR2C -9154.0
POLR2H -8695.0
POLR2I -8128.5
HENMT1 -6194.0
POLR2E -6115.0
TDRKH -5884.0
POLR2G -4537.0
MYBL1 -3422.0
POLR2K -2543.0
PLD6 -1292.0


TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
1072
set TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
setSize 12
pANOVA 0.0252
s.dist -0.373
p.adjustANOVA 0.0856



Top enriched genes

Top 20 genes
GeneID Gene Rank
E2F7 -10596.0
CDKN1B -9945.0
E2F8 -9826.0
CCNE1 -9821.0
CCNA2 -9479.0
PCBP4 -9072.0
TP53 -9069.5
E2F1 -6361.0
CCNE2 -5769.0
ARID3A -5638.0
CDK2 -4039.0
CDKN1A 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
E2F7 -10596.0
CDKN1B -9945.0
E2F8 -9826.0
CCNE1 -9821.0
CCNA2 -9479.0
PCBP4 -9072.0
TP53 -9069.5
E2F1 -6361.0
CCNE2 -5769.0
ARID3A -5638.0
CDK2 -4039.0
CDKN1A 0.5


Striated Muscle Contraction

Striated Muscle Contraction
1033
set Striated Muscle Contraction
setSize 10
pANOVA 0.0428
s.dist -0.37
p.adjustANOVA 0.125



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACTN3 -11030.0
TMOD2 -10730.0
TPM3 -9401.0
TMOD3 -8938.0
TPM4 -8817.0
TPM1 -7645.0
TNNC1 -5621.5
TPM2 -5424.0
MYBPC2 -4411.0
VIM -2473.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACTN3 -11030.0
TMOD2 -10730.0
TPM3 -9401.0
TMOD3 -8938.0
TPM4 -8817.0
TPM1 -7645.0
TNNC1 -5621.5
TPM2 -5424.0
MYBPC2 -4411.0
VIM -2473.0


Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
143
set Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
setSize 13
pANOVA 0.021
s.dist -0.37
p.adjustANOVA 0.0731



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDC25C -10988.0
YWHAE -10498.0
CHEK2 -9953.5
CHEK1 -9425.0
WEE1 -8891.0
YWHAG -8401.0
YWHAZ -7942.0
YWHAH -7477.0
CDK1 -7292.0
YWHAQ -6952.0
CCNB1 -6894.0
YWHAB -2092.0
SFN 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC25C -10988.0
YWHAE -10498.0
CHEK2 -9953.5
CHEK1 -9425.0
WEE1 -8891.0
YWHAG -8401.0
YWHAZ -7942.0
YWHAH -7477.0
CDK1 -7292.0
YWHAQ -6952.0
CCNB1 -6894.0
YWHAB -2092.0
SFN 0.5


Gluconeogenesis

Gluconeogenesis
380
set Gluconeogenesis
setSize 24
pANOVA 0.00183
s.dist -0.367
p.adjustANOVA 0.0134



Top enriched genes

Top 20 genes
GeneID Gene Rank
GAPDH -11174.0
PCK2 -11121.0
TPI1 -11038.0
G6PC3 -10632.0
SLC25A1 -10577.0
GOT1 -10482.0
GOT2 -10001.0
SLC25A11 -9581.5
MDH1 -9340.0
ALDOA -9075.0
SLC37A2 -7786.0
GPI -7324.0
PGAM1 -7190.0
ENO2 -7072.0
SLC25A12 -6858.0
ALDOC -6843.0
SLC25A13 -6521.0
MDH2 -6067.0
PC -5853.0
SLC37A1 -5392.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GAPDH -11174.0
PCK2 -11121.0
TPI1 -11038.0
G6PC3 -10632.0
SLC25A1 -10577.0
GOT1 -10482.0
GOT2 -10001.0
SLC25A11 -9581.5
MDH1 -9340.0
ALDOA -9075.0
SLC37A2 -7786.0
GPI -7324.0
PGAM1 -7190.0
ENO2 -7072.0
SLC25A12 -6858.0
ALDOC -6843.0
SLC25A13 -6521.0
MDH2 -6067.0
PC -5853.0
SLC37A1 -5392.0
SLC37A4 -3950.0
FBP1 -2880.0
ENO3 -2248.0
ENO1 639.0


TNFR1-induced proapoptotic signaling

TNFR1-induced proapoptotic signaling
1064
set TNFR1-induced proapoptotic signaling
setSize 12
pANOVA 0.0277
s.dist -0.367
p.adjustANOVA 0.0903



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNFAIP3 -10736.0
TRADD -10016.5
FADD -9619.0
USP4 -9008.0
CYLD -8822.0
USP2 -7865.0
USP21 -7804.0
TRAF2 -6423.0
TNFRSF1A -6418.0
OTUD7B -6268.0
TNF -4243.0
CASP8 -1951.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNFAIP3 -10736.0
TRADD -10016.5
FADD -9619.0
USP4 -9008.0
CYLD -8822.0
USP2 -7865.0
USP21 -7804.0
TRAF2 -6423.0
TNFRSF1A -6418.0
OTUD7B -6268.0
TNF -4243.0
CASP8 -1951.0


RNA Pol II CTD phosphorylation and interaction with CE

RNA Pol II CTD phosphorylation and interaction with CE
786
set RNA Pol II CTD phosphorylation and interaction with CE
setSize 24
pANOVA 0.00215
s.dist -0.362
p.adjustANOVA 0.0147



Top enriched genes

Top 20 genes
GeneID Gene Rank
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
RNMT -10652.0
GTF2H4 -10604.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
POLR2C -9154.0
SUPT5H -8924.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
ERCC2 -7286.0
CCNH -6561.0
POLR2E -6115.0
POLR2G -4537.0
GTF2H5 -4326.5
CDK7 -4043.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
RNMT -10652.0
GTF2H4 -10604.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
POLR2C -9154.0
SUPT5H -8924.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
ERCC2 -7286.0
CCNH -6561.0
POLR2E -6115.0
POLR2G -4537.0
GTF2H5 -4326.5
CDK7 -4043.0
POLR2K -2543.0
ERCC3 -1456.0
MNAT1 -1257.0
RNGTT -654.0


RNA Pol II CTD phosphorylation and interaction with CE during HIV infection

RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
787
set RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
setSize 24
pANOVA 0.00215
s.dist -0.362
p.adjustANOVA 0.0147



Top enriched genes

Top 20 genes
GeneID Gene Rank
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
RNMT -10652.0
GTF2H4 -10604.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
POLR2C -9154.0
SUPT5H -8924.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
ERCC2 -7286.0
CCNH -6561.0
POLR2E -6115.0
POLR2G -4537.0
GTF2H5 -4326.5
CDK7 -4043.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
RNMT -10652.0
GTF2H4 -10604.0
POLR2F -10444.5
POLR2L -10350.5
GTF2F2 -9899.0
POLR2C -9154.0
SUPT5H -8924.0
POLR2H -8695.0
GTF2F1 -8488.0
POLR2I -8128.5
ERCC2 -7286.0
CCNH -6561.0
POLR2E -6115.0
POLR2G -4537.0
GTF2H5 -4326.5
CDK7 -4043.0
POLR2K -2543.0
ERCC3 -1456.0
MNAT1 -1257.0
RNGTT -654.0


Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects

Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
21
set Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
setSize 16
pANOVA 0.0126
s.dist -0.36
p.adjustANOVA 0.0509



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCND1 -10756.0
CCND3 -10175.0
RB1 -10038.0
CDKN1B -9945.0
CCND2 -9897.0
CCNE1 -9821.0
E2F3 -9422.0
CDK6 -9325.0
CDK4 -7170.0
E2F1 -6361.0
E2F2 -5982.0
CCNE2 -5769.0
TFDP1 -5441.0
TFDP2 -4094.0
CDK2 -4039.0
CDKN1A 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCND1 -10756.0
CCND3 -10175.0
RB1 -10038.0
CDKN1B -9945.0
CCND2 -9897.0
CCNE1 -9821.0
E2F3 -9422.0
CDK6 -9325.0
CDK4 -7170.0
E2F1 -6361.0
E2F2 -5982.0
CCNE2 -5769.0
TFDP1 -5441.0
TFDP2 -4094.0
CDK2 -4039.0
CDKN1A 0.5


Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)

Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
214
set Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
setSize 16
pANOVA 0.0126
s.dist -0.36
p.adjustANOVA 0.0509



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCND1 -10756.0
CCND3 -10175.0
RB1 -10038.0
CDKN1B -9945.0
CCND2 -9897.0
CCNE1 -9821.0
E2F3 -9422.0
CDK6 -9325.0
CDK4 -7170.0
E2F1 -6361.0
E2F2 -5982.0
CCNE2 -5769.0
TFDP1 -5441.0
TFDP2 -4094.0
CDK2 -4039.0
CDKN1A 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCND1 -10756.0
CCND3 -10175.0
RB1 -10038.0
CDKN1B -9945.0
CCND2 -9897.0
CCNE1 -9821.0
E2F3 -9422.0
CDK6 -9325.0
CDK4 -7170.0
E2F1 -6361.0
E2F2 -5982.0
CCNE2 -5769.0
TFDP1 -5441.0
TFDP2 -4094.0
CDK2 -4039.0
CDKN1A 0.5


Interleukin-6 signaling

Interleukin-6 signaling
483
set Interleukin-6 signaling
setSize 10
pANOVA 0.0503
s.dist -0.357
p.adjustANOVA 0.14



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAT3 -10713.0
PTPN11 -10593.0
TYK2 -10551.0
IL6R -10259.0
STAT1 -10196.0
JAK1 -8923.0
IL6ST -7049.0
JAK2 -4656.0
CBL -803.0
SOCS3 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT3 -10713.0
PTPN11 -10593.0
TYK2 -10551.0
IL6R -10259.0
STAT1 -10196.0
JAK1 -8923.0
IL6ST -7049.0
JAK2 -4656.0
CBL -803.0
SOCS3 0.5


Elevation of cytosolic Ca2+ levels

Elevation of cytosolic Ca2+ levels
285
set Elevation of cytosolic Ca2+ levels
setSize 10
pANOVA 0.0561
s.dist -0.349
p.adjustANOVA 0.152



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITPR2 -11186.0
ITPR1 -11002.0
ITPR3 -10416.0
P2RX4 -9630.0
P2RX6 -9236.0
P2RX5 -8602.0
ORAI1 -7966.0
ORAI2 -3919.0
P2RX1 -1274.0
STIM1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITPR2 -11186.0
ITPR1 -11002.0
ITPR3 -10416.0
P2RX4 -9630.0
P2RX6 -9236.0
P2RX5 -8602.0
ORAI1 -7966.0
ORAI2 -3919.0
P2RX1 -1274.0
STIM1 0.5


Other semaphorin interactions

Other semaphorin interactions
664
set Other semaphorin interactions
setSize 10
pANOVA 0.0569
s.dist 0.348
p.adjustANOVA 0.153



Top enriched genes

Top 20 genes
GeneID Gene Rank
SEMA4D 635.0
TYROBP 0.5
PTPRC 0.5
SEMA4A 0.5
CD72 -578.0
PLXNA2 -733.0
PLXND1 -5110.0
PLXNC1 -6810.0
ITGA1 -8600.5
SEMA7A -10236.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SEMA4D 635.0
TYROBP 0.5
PTPRC 0.5
SEMA4A 0.5
CD72 -578.0
PLXNA2 -733.0
PLXND1 -5110.0
PLXNC1 -6810.0
ITGA1 -8600.5
SEMA7A -10236.0


Association of TriC/CCT with target proteins during biosynthesis

Association of TriC/CCT with target proteins during biosynthesis
68
set Association of TriC/CCT with target proteins during biosynthesis
setSize 29
pANOVA 0.0012
s.dist -0.348
p.adjustANOVA 0.0103



Top enriched genes

Top 20 genes
GeneID Gene Rank
NOP56 -11113.0
AP3M1 -11049.0
CCT6A -11037.0
DCAF7 -11024.0
STAT3 -10713.0
SKIV2L -10575.0
FBXW2 -10312.0
CCT3 -10242.0
CCNE1 -9821.0
HDAC3 -9530.0
TP53 -9069.5
WRAP53 -9069.5
FBXW5 -8952.5
CCT7 -8858.0
XRN2 -8446.0
CCT5 -7541.5
CCT8 -7481.0
FBXL3 -7015.0
FBXO6 -6355.0
FBXO4 -5841.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOP56 -11113.0
AP3M1 -11049.0
CCT6A -11037.0
DCAF7 -11024.0
STAT3 -10713.0
SKIV2L -10575.0
FBXW2 -10312.0
CCT3 -10242.0
CCNE1 -9821.0
HDAC3 -9530.0
TP53 -9069.5
WRAP53 -9069.5
FBXW5 -8952.5
CCT7 -8858.0
XRN2 -8446.0
CCT5 -7541.5
CCT8 -7481.0
FBXL3 -7015.0
FBXO6 -6355.0
FBXO4 -5841.0
CCT2 -5786.0
CCNE2 -5769.0
FBXW7 -5235.0
GBA -3368.0
TCP1 -2270.5
FBXW4 -1630.0
LONP2 -1368.0
FBXL5 -1334.0
ARFGEF2 -1252.0


Assembly of the ORC complex at the origin of replication

Assembly of the ORC complex at the origin of replication
66
set Assembly of the ORC complex at the origin of replication
setSize 10
pANOVA 0.0594
s.dist 0.344
p.adjustANOVA 0.158



Top enriched genes

Top 20 genes
GeneID Gene Rank
ORC1 729.0
ORC3 0.5
ORC5 -1006.0
ORC6 -1224.0
KPNA6 -1857.0
ORC4 -2135.5
ORC2 -2972.0
KPNB1 -6441.0
H2AFX -7718.0
KPNA1 -9015.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC1 729.0
ORC3 0.5
ORC5 -1006.0
ORC6 -1224.0
KPNA6 -1857.0
ORC4 -2135.5
ORC2 -2972.0
KPNB1 -6441.0
H2AFX -7718.0
KPNA1 -9015.0


Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
174
set Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
setSize 19
pANOVA 0.00955
s.dist -0.343
p.adjustANOVA 0.0425



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCT6A -11037.0
TUBA1B -10753.0
ACTB -10686.0
CCT3 -10242.0
PFDN2 -9087.5
PFDN5 -9077.0
CCT7 -8858.0
TUBA1C -8240.0
TUBA1A -7788.0
PFDN4 -7758.0
CCT5 -7541.5
CCT8 -7481.0
TUBB2A -6558.0
TUBA4B -5847.5
TUBA4A -5847.5
CCT2 -5786.0
TCP1 -2270.5
TUBB4B -1821.0
PFDN1 -1808.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT6A -11037.0
TUBA1B -10753.0
ACTB -10686.0
CCT3 -10242.0
PFDN2 -9087.5
PFDN5 -9077.0
CCT7 -8858.0
TUBA1C -8240.0
TUBA1A -7788.0
PFDN4 -7758.0
CCT5 -7541.5
CCT8 -7481.0
TUBB2A -6558.0
TUBA4B -5847.5
TUBA4A -5847.5
CCT2 -5786.0
TCP1 -2270.5
TUBB4B -1821.0
PFDN1 -1808.0


Interleukin-35 Signalling

Interleukin-35 Signalling
479
set Interleukin-35 Signalling
setSize 11
pANOVA 0.049
s.dist -0.343
p.adjustANOVA 0.138



Top enriched genes

Top 20 genes
GeneID Gene Rank
IL27RA -10916
STAT3 -10713
TYK2 -10551
STAT1 -10196
JAK1 -8923
IL12RB2 -7456
IL6ST -7049
JAK2 -4656
CANX -4026
STAT4 -3847
IL12A -1812

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IL27RA -10916
STAT3 -10713
TYK2 -10551
STAT1 -10196
JAK1 -8923
IL12RB2 -7456
IL6ST -7049
JAK2 -4656
CANX -4026
STAT4 -3847
IL12A -1812


Competing endogenous RNAs (ceRNAs) regulate PTEN translation

Competing endogenous RNAs (ceRNAs) regulate PTEN translation
162
set Competing endogenous RNAs (ceRNAs) regulate PTEN translation
setSize 10
pANOVA 0.0608
s.dist 0.342
p.adjustANOVA 0.16



Top enriched genes

Top 20 genes
GeneID Gene Rank
MIR19A 662.0
AGO3 0.5
AGO1 0.5
MIR17 -959.0
MOV10 -2677.0
AGO2 -2772.0
CNOT6L -5188.0
TNRC6B -5467.0
TNRC6A -6588.0
VAPA -8759.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MIR19A 662.0
AGO3 0.5
AGO1 0.5
MIR17 -959.0
MOV10 -2677.0
AGO2 -2772.0
CNOT6L -5188.0
TNRC6B -5467.0
TNRC6A -6588.0
VAPA -8759.0


TRAF6 mediated NF-kB activation

TRAF6 mediated NF-kB activation
1077
set TRAF6 mediated NF-kB activation
setSize 19
pANOVA 0.00979
s.dist -0.342
p.adjustANOVA 0.0428



Top enriched genes

Top 20 genes
GeneID Gene Rank
TRIM25 -11033.0
HMGB1 -10875.0
NKIRAS1 -10800.5
NFKB2 -10613.0
RNF135 -10050.0
MAVS -9740.0
NFKBIB -9414.0
TRAF6 -8200.0
RELA -8067.0
DDX58 -7458.0
MAP3K1 -7235.0
NFKBIA -6859.0
TRAF2 -6423.0
IFIH1 -6202.0
IKBKB -4460.0
NKIRAS2 -3663.0
APP -2794.0
CHUK -2433.0
TRIM4 -2043.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRIM25 -11033.0
HMGB1 -10875.0
NKIRAS1 -10800.5
NFKB2 -10613.0
RNF135 -10050.0
MAVS -9740.0
NFKBIB -9414.0
TRAF6 -8200.0
RELA -8067.0
DDX58 -7458.0
MAP3K1 -7235.0
NFKBIA -6859.0
TRAF2 -6423.0
IFIH1 -6202.0
IKBKB -4460.0
NKIRAS2 -3663.0
APP -2794.0
CHUK -2433.0
TRIM4 -2043.0


Binding and Uptake of Ligands by Scavenger Receptors

Binding and Uptake of Ligands by Scavenger Receptors
85
set Binding and Uptake of Ligands by Scavenger Receptors
setSize 10
pANOVA 0.0612
s.dist -0.342
p.adjustANOVA 0.16



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSP90AA1 -10186
SCARB1 -9726
CALR -9146
HSPH1 -8967
FTL -8017
HYOU1 -6702
APOA1 -6403
COL1A1 -4761
HSP90B1 -4737
FTH1 -4165

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSP90AA1 -10186
SCARB1 -9726
CALR -9146
HSPH1 -8967
FTL -8017
HYOU1 -6702
APOA1 -6403
COL1A1 -4761
HSP90B1 -4737
FTH1 -4165


TRAF6 mediated IRF7 activation

TRAF6 mediated IRF7 activation
1076
set TRAF6 mediated IRF7 activation
setSize 16
pANOVA 0.0193
s.dist -0.338
p.adjustANOVA 0.0689



Top enriched genes

Top 20 genes
GeneID Gene Rank
TRIM25 -11033.0
IRF3 -10725.5
IRF7 -10089.0
RNF135 -10050.0
MAVS -9740.0
TRAF6 -8200.0
DDX58 -7458.0
TBK1 -7115.0
EP300 -7023.0
IKBKE -6581.0
TRAF2 -6423.0
IFIH1 -6202.0
TANK -5473.0
SIKE1 -5270.0
CREBBP -2676.0
TRIM4 -2043.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRIM25 -11033.0
IRF3 -10725.5
IRF7 -10089.0
RNF135 -10050.0
MAVS -9740.0
TRAF6 -8200.0
DDX58 -7458.0
TBK1 -7115.0
EP300 -7023.0
IKBKE -6581.0
TRAF2 -6423.0
IFIH1 -6202.0
TANK -5473.0
SIKE1 -5270.0
CREBBP -2676.0
TRIM4 -2043.0


tRNA Aminoacylation

tRNA Aminoacylation
1198
set tRNA Aminoacylation
setSize 23
pANOVA 0.0053
s.dist -0.336
p.adjustANOVA 0.0272



Top enriched genes

Top 20 genes
GeneID Gene Rank
AIMP2 -10621.5
FARSB -10467.0
SARS2 -10229.5
DARS2 -9791.5
EARS2 -9391.5
MARS2 -9378.0
VARS2 -9176.0
FARS2 -8504.5
HARS2 -8135.5
LARS2 -7986.0
WARS2 -7751.0
RARS2 -7085.0
EEF1E1 -6992.0
YARS2 -6796.0
IARS2 -6725.0
CARS2 -6563.0
PPA1 -6217.0
PPA2 -6190.0
AARS2 -5806.0
PARS2 -4518.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AIMP2 -10621.5
FARSB -10467.0
SARS2 -10229.5
DARS2 -9791.5
EARS2 -9391.5
MARS2 -9378.0
VARS2 -9176.0
FARS2 -8504.5
HARS2 -8135.5
LARS2 -7986.0
WARS2 -7751.0
RARS2 -7085.0
EEF1E1 -6992.0
YARS2 -6796.0
IARS2 -6725.0
CARS2 -6563.0
PPA1 -6217.0
PPA2 -6190.0
AARS2 -5806.0
PARS2 -4518.0
TARS2 -3651.0
FARSA -3578.0
NARS2 -1034.0


HIV Transcription Initiation

HIV Transcription Initiation
410
set HIV Transcription Initiation
setSize 39
pANOVA 0.000285
s.dist -0.336
p.adjustANOVA 0.00403



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0
ERCC2 -7286.0
TAF2 -7124.0
GTF2A1 -6885.0
GTF2E2 -6849.0
TAF4B -6681.0
CCNH -6561.0
POLR2E -6115.0
GTF2A2 -5482.0
TAF15 -5476.0
POLR2G -4537.0
GTF2H5 -4326.5
TAF7 -4177.0
CDK7 -4043.0
TAF13 -3575.0
TAF4 -3102.0
POLR2K -2543.0
ERCC3 -1456.0
MNAT1 -1257.0
GTF2B 609.0


RNA Polymerase II HIV Promoter Escape

RNA Polymerase II HIV Promoter Escape
793
set RNA Polymerase II HIV Promoter Escape
setSize 39
pANOVA 0.000285
s.dist -0.336
p.adjustANOVA 0.00403



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0
ERCC2 -7286.0
TAF2 -7124.0
GTF2A1 -6885.0
GTF2E2 -6849.0
TAF4B -6681.0
CCNH -6561.0
POLR2E -6115.0
GTF2A2 -5482.0
TAF15 -5476.0
POLR2G -4537.0
GTF2H5 -4326.5
TAF7 -4177.0
CDK7 -4043.0
TAF13 -3575.0
TAF4 -3102.0
POLR2K -2543.0
ERCC3 -1456.0
MNAT1 -1257.0
GTF2B 609.0


RNA Polymerase II Promoter Escape

RNA Polymerase II Promoter Escape
795
set RNA Polymerase II Promoter Escape
setSize 39
pANOVA 0.000285
s.dist -0.336
p.adjustANOVA 0.00403



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0
ERCC2 -7286.0
TAF2 -7124.0
GTF2A1 -6885.0
GTF2E2 -6849.0
TAF4B -6681.0
CCNH -6561.0
POLR2E -6115.0
GTF2A2 -5482.0
TAF15 -5476.0
POLR2G -4537.0
GTF2H5 -4326.5
TAF7 -4177.0
CDK7 -4043.0
TAF13 -3575.0
TAF4 -3102.0
POLR2K -2543.0
ERCC3 -1456.0
MNAT1 -1257.0
GTF2B 609.0


RNA Polymerase II Transcription Initiation

RNA Polymerase II Transcription Initiation
798
set RNA Polymerase II Transcription Initiation
setSize 39
pANOVA 0.000285
s.dist -0.336
p.adjustANOVA 0.00403



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0
ERCC2 -7286.0
TAF2 -7124.0
GTF2A1 -6885.0
GTF2E2 -6849.0
TAF4B -6681.0
CCNH -6561.0
POLR2E -6115.0
GTF2A2 -5482.0
TAF15 -5476.0
POLR2G -4537.0
GTF2H5 -4326.5
TAF7 -4177.0
CDK7 -4043.0
TAF13 -3575.0
TAF4 -3102.0
POLR2K -2543.0
ERCC3 -1456.0
MNAT1 -1257.0
GTF2B 609.0


RNA Polymerase II Transcription Initiation And Promoter Clearance

RNA Polymerase II Transcription Initiation And Promoter Clearance
799
set RNA Polymerase II Transcription Initiation And Promoter Clearance
setSize 39
pANOVA 0.000285
s.dist -0.336
p.adjustANOVA 0.00403



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0
ERCC2 -7286.0
TAF2 -7124.0
GTF2A1 -6885.0
GTF2E2 -6849.0
TAF4B -6681.0
CCNH -6561.0
POLR2E -6115.0
GTF2A2 -5482.0
TAF15 -5476.0
POLR2G -4537.0
GTF2H5 -4326.5
TAF7 -4177.0
CDK7 -4043.0
TAF13 -3575.0
TAF4 -3102.0
POLR2K -2543.0
ERCC3 -1456.0
MNAT1 -1257.0
GTF2B 609.0


RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
800
set RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
setSize 39
pANOVA 0.000285
s.dist -0.336
p.adjustANOVA 0.00403



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAF9 -11093.5
GTF2H3 -10896.5
POLR2B -10873.0
POLR2D -10844.0
POLR2A -10840.0
GTF2H4 -10604.0
TBP -10521.5
POLR2F -10444.5
POLR2L -10350.5
TAF6 -10321.5
TAF3 -10203.0
TAF11 -9974.5
GTF2F2 -9899.0
POLR2C -9154.0
POLR2H -8695.0
TAF10 -8619.0
GTF2F1 -8488.0
POLR2I -8128.5
TAF12 -7895.0
TAF5 -7656.0
ERCC2 -7286.0
TAF2 -7124.0
GTF2A1 -6885.0
GTF2E2 -6849.0
TAF4B -6681.0
CCNH -6561.0
POLR2E -6115.0
GTF2A2 -5482.0
TAF15 -5476.0
POLR2G -4537.0
GTF2H5 -4326.5
TAF7 -4177.0
CDK7 -4043.0
TAF13 -3575.0
TAF4 -3102.0
POLR2K -2543.0
ERCC3 -1456.0
MNAT1 -1257.0
GTF2B 609.0


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report