date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                metric
## TAPBP      -10.950207
## SLC39A1     -8.499671
## NCRNA00171  -6.889772
## ZNRD1       -6.889772
## RGL2        -8.751387
## KIAA1949    -9.062842
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2546
num_genes_in_profile 12012
duplicated_genes_present 0
num_profile_genes_in_sets 5835
num_profile_genes_not_in_sets 6177

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2546
num_genesets_excluded 1344
num_genesets_included 1202

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
NRIF signals cell death from the nucleus 14 1.75e-04 -0.579 0.002040
SARS-CoV-2 modulates autophagy 11 1.81e-03 -0.543 0.012400
p75NTR signals via NF-kB 11 2.67e-03 -0.523 0.015800
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 1.56e-02 0.441 0.058800
Condensation of Prometaphase Chromosomes 10 1.75e-02 -0.434 0.063600
Translesion Synthesis by POLH 17 2.71e-03 -0.420 0.015800
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 1.31e-02 -0.413 0.051400
Diseases associated with N-glycosylation of proteins 18 2.77e-03 -0.407 0.016000
TNFR1-induced proapoptotic signaling 12 1.45e-02 -0.407 0.055900
Methylation 10 2.83e-02 -0.400 0.090400
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 7.72e-03 -0.397 0.035400
Signaling by FGFR2 IIIa TM 15 9.05e-03 -0.389 0.040500
Signaling by ERBB2 ECD mutants 10 4.05e-02 -0.374 0.121000
Bile acid and bile salt metabolism 15 1.25e-02 0.373 0.049600
Signaling by NOTCH2 18 6.21e-03 -0.372 0.030500
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 1.72e-02 -0.368 0.063000
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 1.72e-02 -0.368 0.063000
CLEC7A (Dectin-1) induces NFAT activation 11 3.58e-02 -0.365 0.111000
RORA activates gene expression 11 3.66e-02 -0.364 0.113000
Autodegradation of the E3 ubiquitin ligase COP1 44 2.98e-05 -0.364 0.000716
RNA Polymerase III Transcription Termination 21 4.54e-03 -0.358 0.023500
Cross-presentation of soluble exogenous antigens (endosomes) 38 1.37e-04 -0.358 0.001710
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 6.12e-05 -0.357 0.000976
Regulation of PTEN stability and activity 56 3.78e-06 -0.357 0.000160
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 44 4.67e-05 -0.355 0.000851
p53-Independent DNA Damage Response 44 4.67e-05 -0.355 0.000851
p53-Independent G1/S DNA damage checkpoint 44 4.67e-05 -0.355 0.000851
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 5.29e-02 0.353 0.149000
Degradation of AXIN 47 3.17e-05 -0.351 0.000720
Regulation of Apoptosis 45 4.91e-05 -0.350 0.000867
mRNA Capping 26 2.03e-03 -0.350 0.013300
Ubiquitin-dependent degradation of Cyclin D 44 6.25e-05 -0.349 0.000976
Postmitotic nuclear pore complex (NPC) reformation 26 2.10e-03 -0.348 0.013500
Caspase activation via Death Receptors in the presence of ligand 10 5.64e-02 -0.348 0.156000
Constitutive Signaling by EGFRvIII 10 5.78e-02 -0.346 0.158000
Signaling by EGFRvIII in Cancer 10 5.78e-02 -0.346 0.158000
Gap-filling DNA repair synthesis and ligation in GG-NER 23 4.52e-03 -0.342 0.023500
Negative regulation of NOTCH4 signaling 48 4.87e-05 -0.339 0.000867
Degradation of DVL 48 5.13e-05 -0.338 0.000881
Glycogen synthesis 11 5.33e-02 -0.336 0.150000
Assembly of the ORC complex at the origin of replication 10 6.55e-02 0.336 0.173000
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 8.09e-05 -0.336 0.001190
Purine salvage 11 5.44e-02 -0.335 0.153000
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 3.72e-02 -0.334 0.114000
Stabilization of p53 49 5.51e-05 -0.333 0.000919
Aggrephagy 19 1.20e-02 -0.333 0.048400
Regulation of RUNX3 expression and activity 49 5.58e-05 -0.333 0.000919
TRAF6 mediated NF-kB activation 19 1.22e-02 -0.332 0.049000
p53-Dependent G1 DNA Damage Response 56 1.79e-05 -0.331 0.000553
p53-Dependent G1/S DNA damage checkpoint 56 1.79e-05 -0.331 0.000553


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
NRIF signals cell death from the nucleus 14 1.75e-04 -5.79e-01 2.04e-03
SARS-CoV-2 modulates autophagy 11 1.81e-03 -5.43e-01 1.24e-02
p75NTR signals via NF-kB 11 2.67e-03 -5.23e-01 1.58e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 1.56e-02 4.41e-01 5.88e-02
Condensation of Prometaphase Chromosomes 10 1.75e-02 -4.34e-01 6.36e-02
Translesion Synthesis by POLH 17 2.71e-03 -4.20e-01 1.58e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 1.31e-02 -4.13e-01 5.14e-02
Diseases associated with N-glycosylation of proteins 18 2.77e-03 -4.07e-01 1.60e-02
TNFR1-induced proapoptotic signaling 12 1.45e-02 -4.07e-01 5.59e-02
Methylation 10 2.83e-02 -4.00e-01 9.04e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 7.72e-03 -3.97e-01 3.54e-02
Signaling by FGFR2 IIIa TM 15 9.05e-03 -3.89e-01 4.05e-02
Signaling by ERBB2 ECD mutants 10 4.05e-02 -3.74e-01 1.21e-01
Bile acid and bile salt metabolism 15 1.25e-02 3.73e-01 4.96e-02
Signaling by NOTCH2 18 6.21e-03 -3.72e-01 3.05e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 1.72e-02 -3.68e-01 6.30e-02
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 1.72e-02 -3.68e-01 6.30e-02
CLEC7A (Dectin-1) induces NFAT activation 11 3.58e-02 -3.65e-01 1.11e-01
RORA activates gene expression 11 3.66e-02 -3.64e-01 1.13e-01
Autodegradation of the E3 ubiquitin ligase COP1 44 2.98e-05 -3.64e-01 7.16e-04
RNA Polymerase III Transcription Termination 21 4.54e-03 -3.58e-01 2.35e-02
Cross-presentation of soluble exogenous antigens (endosomes) 38 1.37e-04 -3.58e-01 1.71e-03
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 6.12e-05 -3.57e-01 9.76e-04
Regulation of PTEN stability and activity 56 3.78e-06 -3.57e-01 1.60e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 44 4.67e-05 -3.55e-01 8.51e-04
p53-Independent DNA Damage Response 44 4.67e-05 -3.55e-01 8.51e-04
p53-Independent G1/S DNA damage checkpoint 44 4.67e-05 -3.55e-01 8.51e-04
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 5.29e-02 3.53e-01 1.49e-01
Degradation of AXIN 47 3.17e-05 -3.51e-01 7.20e-04
Regulation of Apoptosis 45 4.91e-05 -3.50e-01 8.67e-04
mRNA Capping 26 2.03e-03 -3.50e-01 1.33e-02
Ubiquitin-dependent degradation of Cyclin D 44 6.25e-05 -3.49e-01 9.76e-04
Postmitotic nuclear pore complex (NPC) reformation 26 2.10e-03 -3.48e-01 1.35e-02
Caspase activation via Death Receptors in the presence of ligand 10 5.64e-02 -3.48e-01 1.56e-01
Constitutive Signaling by EGFRvIII 10 5.78e-02 -3.46e-01 1.58e-01
Signaling by EGFRvIII in Cancer 10 5.78e-02 -3.46e-01 1.58e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 23 4.52e-03 -3.42e-01 2.35e-02
Negative regulation of NOTCH4 signaling 48 4.87e-05 -3.39e-01 8.67e-04
Degradation of DVL 48 5.13e-05 -3.38e-01 8.81e-04
Glycogen synthesis 11 5.33e-02 -3.36e-01 1.50e-01
Assembly of the ORC complex at the origin of replication 10 6.55e-02 3.36e-01 1.73e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 8.09e-05 -3.36e-01 1.19e-03
Purine salvage 11 5.44e-02 -3.35e-01 1.53e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 3.72e-02 -3.34e-01 1.14e-01
Stabilization of p53 49 5.51e-05 -3.33e-01 9.19e-04
Aggrephagy 19 1.20e-02 -3.33e-01 4.84e-02
Regulation of RUNX3 expression and activity 49 5.58e-05 -3.33e-01 9.19e-04
TRAF6 mediated NF-kB activation 19 1.22e-02 -3.32e-01 4.90e-02
p53-Dependent G1 DNA Damage Response 56 1.79e-05 -3.31e-01 5.53e-04
p53-Dependent G1/S DNA damage checkpoint 56 1.79e-05 -3.31e-01 5.53e-04
Vif-mediated degradation of APOBEC3G 43 1.81e-04 -3.30e-01 2.07e-03
Lagging Strand Synthesis 17 1.85e-02 -3.30e-01 6.60e-02
Glycogen metabolism 17 1.91e-02 -3.28e-01 6.74e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 2.79e-02 -3.28e-01 8.96e-02
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 46 1.23e-04 -3.27e-01 1.55e-03
SCF(Skp2)-mediated degradation of p27/p21 52 4.56e-05 -3.27e-01 8.51e-04
Signaling by NOTCH4 68 3.32e-06 -3.26e-01 1.53e-04
G1/S DNA Damage Checkpoints 58 1.91e-05 -3.25e-01 5.60e-04
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 5.24e-02 -3.23e-01 1.48e-01
Regulation of PTEN mRNA translation 11 6.43e-02 3.22e-01 1.71e-01
Glyoxylate metabolism and glycine degradation 19 1.51e-02 -3.22e-01 5.74e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 10 7.92e-02 -3.20e-01 1.98e-01
Vpu mediated degradation of CD4 44 2.36e-04 -3.20e-01 2.56e-03
RNA Pol II CTD phosphorylation and interaction with CE 24 6.60e-03 -3.20e-01 3.16e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 24 6.60e-03 -3.20e-01 3.16e-02
G0 and Early G1 24 6.84e-03 -3.19e-01 3.22e-02
Processive synthesis on the lagging strand 13 4.69e-02 -3.18e-01 1.35e-01
Caspase activation via extrinsic apoptotic signalling pathway 15 3.33e-02 -3.17e-01 1.04e-01
Degradation of GLI2 by the proteasome 50 1.07e-04 -3.17e-01 1.40e-03
GLI3 is processed to GLI3R by the proteasome 50 1.07e-04 -3.17e-01 1.40e-03
Autodegradation of Cdh1 by Cdh1:APC/C 56 4.16e-05 -3.17e-01 8.51e-04
TNFs bind their physiological receptors 10 8.28e-02 3.17e-01 2.01e-01
UCH proteinases 74 2.82e-06 -3.15e-01 1.48e-04
RHO GTPases Activate WASPs and WAVEs 29 3.41e-03 -3.14e-01 1.93e-02
APC/C:Cdc20 mediated degradation of Securin 58 3.57e-05 -3.14e-01 7.80e-04
HDR through Single Strand Annealing (SSA) 35 1.38e-03 -3.12e-01 1.02e-02
TP53 Regulates Transcription of DNA Repair Genes 52 1.03e-04 -3.11e-01 1.40e-03
RUNX3 regulates p14-ARF 10 8.93e-02 -3.10e-01 2.15e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 55 7.23e-05 -3.09e-01 1.09e-03
CDK-mediated phosphorylation and removal of Cdc6 62 2.53e-05 -3.09e-01 6.46e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 62 2.63e-05 -3.09e-01 6.46e-04
Degradation of GLI1 by the proteasome 51 1.39e-04 -3.09e-01 1.72e-03
Transcription of the HIV genome 57 5.69e-05 -3.08e-01 9.25e-04
Translesion synthesis by POLK 15 3.87e-02 -3.08e-01 1.17e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 63 2.38e-05 -3.08e-01 6.27e-04
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 6.48e-02 -3.08e-01 1.72e-01
Synthesis of bile acids and bile salts 13 5.63e-02 3.06e-01 1.56e-01
Regulation of ornithine decarboxylase (ODC) 43 5.61e-04 -3.04e-01 5.08e-03
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 69 1.32e-05 -3.03e-01 4.67e-04
HIV Transcription Initiation 39 1.06e-03 -3.03e-01 8.15e-03
RNA Polymerase II HIV Promoter Escape 39 1.06e-03 -3.03e-01 8.15e-03
RNA Polymerase II Promoter Escape 39 1.06e-03 -3.03e-01 8.15e-03
RNA Polymerase II Transcription Initiation 39 1.06e-03 -3.03e-01 8.15e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance 39 1.06e-03 -3.03e-01 8.15e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 39 1.06e-03 -3.03e-01 8.15e-03
Metabolism of polyamines 48 2.84e-04 -3.03e-01 2.99e-03
Regulation of TP53 Expression and Degradation 34 2.31e-03 -3.02e-01 1.44e-02
TRAF6 mediated IRF7 activation 16 3.80e-02 -3.00e-01 1.15e-01
SCF-beta-TrCP mediated degradation of Emi1 47 3.90e-04 -2.99e-01 3.81e-03
Dual incision in TC-NER 56 1.10e-04 -2.99e-01 1.42e-03
HIV elongation arrest and recovery 27 7.43e-03 -2.98e-01 3.44e-02
Pausing and recovery of HIV elongation 27 7.43e-03 -2.98e-01 3.44e-02
Formation of HIV elongation complex in the absence of HIV Tat 37 1.78e-03 -2.97e-01 1.23e-02
Voltage gated Potassium channels 13 6.47e-02 2.96e-01 1.72e-01
Hh mutants are degraded by ERAD 47 4.68e-04 -2.95e-01 4.50e-03
APC/C:Cdc20 mediated degradation of mitotic proteins 65 3.97e-05 -2.95e-01 8.37e-04
Synaptic adhesion-like molecules 10 1.07e-01 2.94e-01 2.46e-01
PCNA-Dependent Long Patch Base Excision Repair 18 3.09e-02 -2.94e-01 9.74e-02
Transcription of E2F targets under negative control by DREAM complex 18 3.10e-02 -2.94e-01 9.74e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 22 1.72e-02 -2.94e-01 6.30e-02
Association of TriC/CCT with target proteins during biosynthesis 29 6.32e-03 -2.93e-01 3.07e-02
VLDLR internalisation and degradation 11 9.40e-02 -2.92e-01 2.21e-01
Ovarian tumor domain proteases 29 6.79e-03 -2.90e-01 3.22e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 36 2.68e-03 -2.89e-01 1.58e-02
HIV Transcription Elongation 36 2.68e-03 -2.89e-01 1.58e-02
Tat-mediated elongation of the HIV-1 transcript 36 2.68e-03 -2.89e-01 1.58e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 26 1.08e-02 -2.89e-01 4.54e-02
Regulation of TP53 Degradation 33 4.10e-03 -2.89e-01 2.20e-02
Cyclin E associated events during G1/S transition 72 2.40e-05 -2.88e-01 6.27e-04
RUNX1 regulates transcription of genes involved in differentiation of HSCs 57 1.78e-04 -2.87e-01 2.06e-03
Pausing and recovery of Tat-mediated HIV elongation 26 1.13e-02 -2.87e-01 4.64e-02
Tat-mediated HIV elongation arrest and recovery 26 1.13e-02 -2.87e-01 4.64e-02
RNA Polymerase III Chain Elongation 17 4.21e-02 -2.85e-01 1.24e-01
Collagen degradation 14 6.53e-02 2.84e-01 1.73e-01
Early Phase of HIV Life Cycle 13 7.58e-02 -2.84e-01 1.92e-01
Notch-HLH transcription pathway 21 2.47e-02 -2.83e-01 8.21e-02
RIPK1-mediated regulated necrosis 25 1.44e-02 -2.83e-01 5.54e-02
Regulation of necroptotic cell death 25 1.44e-02 -2.83e-01 5.54e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 27 1.11e-02 -2.82e-01 4.63e-02
Translesion synthesis by POLI 15 5.84e-02 -2.82e-01 1.59e-01
Hh mutants abrogate ligand secretion 49 6.41e-04 -2.82e-01 5.62e-03
Removal of the Flap Intermediate 12 9.08e-02 -2.82e-01 2.17e-01
Asymmetric localization of PCP proteins 51 5.15e-04 -2.81e-01 4.77e-03
Cyclin A:Cdk2-associated events at S phase entry 74 3.11e-05 -2.80e-01 7.20e-04
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 66 8.57e-05 -2.80e-01 1.24e-03
Hedgehog ligand biogenesis 52 4.99e-04 -2.79e-01 4.69e-03
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 1.09e-01 -2.79e-01 2.48e-01
Viral Messenger RNA Synthesis 41 2.01e-03 -2.79e-01 1.32e-02
Sphingolipid de novo biosynthesis 22 2.40e-02 2.78e-01 8.09e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 35 4.48e-03 -2.78e-01 2.35e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 52 5.50e-04 -2.77e-01 5.04e-03
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 1.12e-01 -2.77e-01 2.52e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 1.13e-01 -2.76e-01 2.53e-01
HCMV Early Events 50 7.84e-04 -2.75e-01 6.59e-03
Cytochrome c-mediated apoptotic response 11 1.16e-01 -2.74e-01 2.57e-01
G1/S-Specific Transcription 27 1.38e-02 -2.74e-01 5.36e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 1.32e-03 -2.74e-01 9.83e-03
Endosomal/Vacuolar pathway 10 1.37e-01 -2.72e-01 2.91e-01
Formation of TC-NER Pre-Incision Complex 46 1.46e-03 -2.71e-01 1.05e-02
Transport of the SLBP Dependant Mature mRNA 34 6.29e-03 -2.71e-01 3.07e-02
Resolution of Abasic Sites (AP sites) 31 9.49e-03 -2.69e-01 4.16e-02
Export of Viral Ribonucleoproteins from Nucleus 31 9.61e-03 -2.69e-01 4.20e-02
Regulation of pyruvate dehydrogenase (PDH) complex 11 1.23e-01 -2.68e-01 2.70e-01
Nuclear import of Rev protein 31 9.90e-03 -2.68e-01 4.28e-02
Translesion synthesis by REV1 14 8.34e-02 -2.67e-01 2.03e-01
Transport of the SLBP independent Mature mRNA 33 7.93e-03 -2.67e-01 3.61e-02
Formation of the Early Elongation Complex 30 1.15e-02 -2.67e-01 4.68e-02
Formation of the HIV-1 Early Elongation Complex 30 1.15e-02 -2.67e-01 4.68e-02
Processing of DNA double-strand break ends 55 6.29e-04 -2.67e-01 5.56e-03
Activation of NF-kappaB in B cells 57 5.03e-04 -2.67e-01 4.69e-03
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 18 5.05e-02 -2.66e-01 1.44e-01
Interleukin-1 signaling 79 4.65e-05 -2.65e-01 8.51e-04
Dectin-1 mediated noncanonical NF-kB signaling 52 9.57e-04 -2.65e-01 7.83e-03
Downregulation of TGF-beta receptor signaling 26 1.97e-02 -2.64e-01 6.90e-02
FGFR2 mutant receptor activation 17 5.95e-02 -2.64e-01 1.62e-01
Syndecan interactions 10 1.49e-01 -2.64e-01 3.06e-01
FGFR2 alternative splicing 22 3.23e-02 -2.64e-01 1.01e-01
Regulation of expression of SLITs and ROBOs 124 4.25e-07 -2.63e-01 3.00e-05
Homology Directed Repair 90 1.64e-05 -2.63e-01 5.53e-04
CLEC7A (Dectin-1) signaling 84 3.15e-05 -2.63e-01 7.20e-04
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 6.89e-02 -2.63e-01 1.80e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 6.89e-02 -2.63e-01 1.80e-01
NIK–>noncanonical NF-kB signaling 51 1.21e-03 -2.62e-01 9.11e-03
Arachidonic acid metabolism 21 3.78e-02 2.62e-01 1.15e-01
Potassium Channels 30 1.31e-02 2.62e-01 5.14e-02
Diseases of DNA repair 45 2.45e-03 -2.61e-01 1.50e-02
Regulation of TP53 Activity through Phosphorylation 79 6.22e-05 -2.61e-01 9.76e-04
RHO GTPases Activate NADPH Oxidases 14 9.14e-02 -2.61e-01 2.17e-01
ER-Phagosome pathway 69 1.88e-04 -2.60e-01 2.12e-03
Signaling by PDGFR in disease 15 8.11e-02 -2.60e-01 2.00e-01
MAPK6/MAPK4 signaling 69 1.89e-04 -2.60e-01 2.12e-03
mRNA decay by 5’ to 3’ exoribonuclease 15 8.16e-02 -2.60e-01 2.00e-01
Downregulation of ERBB2:ERBB3 signaling 10 1.55e-01 -2.60e-01 3.17e-01
Transcriptional regulation by RUNX3 75 1.04e-04 -2.59e-01 1.40e-03
FLT3 signaling in disease 24 2.83e-02 -2.59e-01 9.04e-02
FCERI mediated NF-kB activation 64 3.53e-04 -2.58e-01 3.57e-03
Nuclear events mediated by NFE2L2 67 2.58e-04 -2.58e-01 2.77e-03
Regulation of RUNX2 expression and activity 57 7.58e-04 -2.58e-01 6.46e-03
Antigen processing-Cross presentation 76 1.05e-04 -2.58e-01 1.40e-03
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 84 4.62e-05 -2.57e-01 8.51e-04
Signaling by NOTCH3 30 1.49e-02 -2.57e-01 5.69e-02
Signaling by EGFR in Cancer 16 7.55e-02 -2.57e-01 1.92e-01
Regulation of RAS by GAPs 56 9.07e-04 -2.56e-01 7.52e-03
Rev-mediated nuclear export of HIV RNA 33 1.08e-02 -2.56e-01 4.55e-02
Rap1 signalling 11 1.42e-01 -2.56e-01 2.99e-01
Keratan sulfate/keratin metabolism 18 6.03e-02 -2.56e-01 1.63e-01
Downstream signaling events of B Cell Receptor (BCR) 70 2.21e-04 -2.55e-01 2.44e-03
Vpr-mediated nuclear import of PICs 32 1.24e-02 -2.55e-01 4.96e-02
Defects in vitamin and cofactor metabolism 16 7.73e-02 -2.55e-01 1.95e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 1.14e-01 -2.53e-01 2.55e-01
TICAM1-dependent activation of IRF3/IRF7 12 1.29e-01 -2.53e-01 2.80e-01
RNA Polymerase II Pre-transcription Events 68 3.41e-04 -2.51e-01 3.47e-03
DNA strand elongation 28 2.15e-02 -2.51e-01 7.39e-02
DNA Damage Bypass 42 4.97e-03 -2.51e-01 2.52e-02
Fanconi Anemia Pathway 31 1.58e-02 -2.51e-01 5.93e-02
Class I peroxisomal membrane protein import 19 5.95e-02 -2.50e-01 1.62e-01
B-WICH complex positively regulates rRNA expression 27 2.47e-02 -2.50e-01 8.21e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 28 2.24e-02 -2.49e-01 7.63e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 28 2.24e-02 -2.49e-01 7.63e-02
TBC/RABGAPs 40 6.38e-03 -2.49e-01 3.08e-02
Homologous DNA Pairing and Strand Exchange 39 7.15e-03 -2.49e-01 3.34e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 64 5.82e-04 -2.49e-01 5.22e-03
Glycosphingolipid metabolism 27 2.55e-02 -2.48e-01 8.36e-02
Peptide ligand-binding receptors 20 5.55e-02 2.47e-01 1.56e-01
Other semaphorin interactions 10 1.76e-01 2.47e-01 3.45e-01
Interactions of Rev with host cellular proteins 34 1.27e-02 -2.47e-01 5.03e-02
Signaling by ROBO receptors 154 1.33e-07 -2.47e-01 1.14e-05
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 37 9.41e-03 -2.47e-01 4.16e-02
Diseases of DNA Double-Strand Break Repair 37 9.41e-03 -2.47e-01 4.16e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 41 6.33e-03 -2.46e-01 3.07e-02
NEP/NS2 Interacts with the Cellular Export Machinery 30 2.06e-02 -2.44e-01 7.14e-02
Prefoldin mediated transfer of substrate to CCT/TriC 17 8.14e-02 -2.44e-01 2.00e-01
Transport of Mature mRNA Derived from an Intronless Transcript 40 7.89e-03 -2.43e-01 3.61e-02
Nucleotide Excision Repair 99 3.27e-05 -2.42e-01 7.27e-04
Assembly of the pre-replicative complex 76 2.77e-04 -2.41e-01 2.95e-03
Metabolism of folate and pterines 11 1.66e-01 -2.41e-01 3.32e-01
Termination of translesion DNA synthesis 28 2.72e-02 -2.41e-01 8.78e-02
Degradation of beta-catenin by the destruction complex 68 6.09e-04 -2.41e-01 5.42e-03
Dual Incision in GG-NER 35 1.40e-02 -2.40e-01 5.44e-02
Disorders of Developmental Biology 10 1.90e-01 -2.39e-01 3.65e-01
Disorders of Nervous System Development 10 1.90e-01 -2.39e-01 3.65e-01
Loss of function of MECP2 in Rett syndrome 10 1.90e-01 -2.39e-01 3.65e-01
Pervasive developmental disorders 10 1.90e-01 -2.39e-01 3.65e-01
Pexophagy 11 1.71e-01 -2.38e-01 3.40e-01
HDR through Homologous Recombination (HRR) 60 1.42e-03 -2.38e-01 1.03e-02
Anchoring of the basal body to the plasma membrane 80 2.35e-04 -2.38e-01 2.56e-03
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 53 2.75e-03 -2.38e-01 1.60e-02
Leading Strand Synthesis 12 1.54e-01 -2.38e-01 3.15e-01
Polymerase switching 12 1.54e-01 -2.38e-01 3.15e-01
Apoptotic factor-mediated response 16 9.99e-02 -2.38e-01 2.32e-01
HIV Life Cycle 129 3.56e-06 -2.37e-01 1.58e-04
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 26 3.71e-02 -2.36e-01 1.14e-01
Signaling by FGFR2 in disease 24 4.54e-02 -2.36e-01 1.32e-01
Separation of Sister Chromatids 147 8.24e-07 -2.36e-01 5.50e-05
Synthesis of PIPs at the Golgi membrane 12 1.57e-01 -2.36e-01 3.20e-01
KEAP1-NFE2L2 pathway 86 1.67e-04 -2.35e-01 1.99e-03
RNA Polymerase I Transcription Termination 25 4.21e-02 -2.35e-01 1.24e-01
Class A/1 (Rhodopsin-like receptors) 49 4.60e-03 2.34e-01 2.37e-02
S Phase 141 1.69e-06 -2.34e-01 9.22e-05
Influenza Viral RNA Transcription and Replication 113 1.84e-05 -2.34e-01 5.53e-04
Downstream TCR signaling 71 7.04e-04 -2.33e-01 6.09e-03
mRNA Splicing - Minor Pathway 49 4.92e-03 -2.32e-01 2.50e-02
Interactions of Vpr with host cellular proteins 33 2.10e-02 -2.32e-01 7.28e-02
Synthesis of DNA 106 3.73e-05 -2.32e-01 8.00e-04
DNA Replication Pre-Initiation 90 1.44e-04 -2.32e-01 1.76e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 19 8.00e-02 -2.32e-01 1.98e-01
G-protein activation 13 1.48e-01 2.32e-01 3.04e-01
Ub-specific processing proteases 134 3.87e-06 -2.31e-01 1.60e-04
Cellular response to hypoxia 60 1.95e-03 -2.31e-01 1.30e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 27 3.80e-02 -2.31e-01 1.15e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 41 1.07e-02 -2.31e-01 4.51e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants 41 1.07e-02 -2.31e-01 4.51e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 41 1.07e-02 -2.31e-01 4.51e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer 41 1.07e-02 -2.31e-01 4.51e-02
Signaling by NOTCH1 in Cancer 41 1.07e-02 -2.31e-01 4.51e-02
Presynaptic phase of homologous DNA pairing and strand exchange 36 1.68e-02 -2.30e-01 6.23e-02
Regulation of APC/C activators between G1/S and early anaphase 70 8.75e-04 -2.30e-01 7.30e-03
Host Interactions of HIV factors 106 4.52e-05 -2.30e-01 8.51e-04
Recognition of DNA damage by PCNA-containing replication complex 26 4.37e-02 -2.29e-01 1.27e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 20 7.72e-02 -2.28e-01 1.95e-01
DNA Double-Strand Break Repair 117 2.09e-05 -2.28e-01 5.90e-04
SUMOylation of ubiquitinylation proteins 37 1.65e-02 -2.28e-01 6.14e-02
RNA Polymerase I Transcription Initiation 40 1.27e-02 -2.28e-01 5.03e-02
DNA Damage Recognition in GG-NER 35 1.97e-02 -2.28e-01 6.90e-02
G1/S Transition 115 2.61e-05 -2.27e-01 6.46e-04
Signal transduction by L1 11 1.92e-01 -2.27e-01 3.68e-01
Mitotic G1 phase and G1/S transition 129 8.74e-06 -2.27e-01 3.28e-04
Smooth Muscle Contraction 19 8.67e-02 -2.27e-01 2.10e-01
Signaling by FLT3 fusion proteins 16 1.16e-01 -2.27e-01 2.58e-01
Orc1 removal from chromatin 62 2.02e-03 -2.27e-01 1.33e-02
Impaired BRCA2 binding to RAD51 32 2.64e-02 -2.27e-01 8.59e-02
Late Phase of HIV Life Cycle 117 2.36e-05 -2.27e-01 6.27e-04
Inhibition of DNA recombination at telomere 18 9.61e-02 -2.27e-01 2.25e-01
Deactivation of the beta-catenin transactivating complex 28 3.80e-02 -2.27e-01 1.15e-01
SUMOylation of SUMOylation proteins 32 2.69e-02 -2.26e-01 8.73e-02
HIV Infection 190 9.04e-08 -2.25e-01 9.88e-06
Formation of RNA Pol II elongation complex 50 6.02e-03 -2.25e-01 2.96e-02
RNA Polymerase II Transcription Elongation 50 6.02e-03 -2.25e-01 2.96e-02
Transcriptional regulation by small RNAs 45 9.48e-03 -2.24e-01 4.16e-02
Heme signaling 26 4.89e-02 -2.23e-01 1.41e-01
Base Excision Repair 38 1.75e-02 -2.23e-01 6.36e-02
Viral mRNA Translation 69 1.39e-03 -2.23e-01 1.02e-02
Defective CFTR causes cystic fibrosis 52 5.51e-03 -2.23e-01 2.75e-02
Mismatch Repair 13 1.65e-01 -2.22e-01 3.31e-01
Loss of Nlp from mitotic centrosomes 56 4.03e-03 -2.22e-01 2.17e-02
Loss of proteins required for interphase microtubule organization from the centrosome 56 4.03e-03 -2.22e-01 2.17e-02
Positive epigenetic regulation of rRNA expression 40 1.56e-02 -2.21e-01 5.88e-02
Transcriptional Regulation by E2F6 29 3.94e-02 -2.21e-01 1.18e-01
Cytoprotection by HMOX1 44 1.13e-02 -2.21e-01 4.65e-02
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 22 7.32e-02 -2.21e-01 1.88e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 22 7.32e-02 -2.21e-01 1.88e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 22 7.32e-02 -2.21e-01 1.88e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 22 7.32e-02 -2.21e-01 1.88e-01
Impaired BRCA2 binding to PALB2 22 7.32e-02 -2.21e-01 1.88e-01
DNA Repair 248 2.48e-09 -2.21e-01 2.98e-07
AURKA Activation by TPX2 59 3.46e-03 -2.20e-01 1.94e-02
Global Genome Nucleotide Excision Repair (GG-NER) 76 9.16e-04 -2.20e-01 7.54e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 74 1.12e-03 -2.19e-01 8.55e-03
Beta-catenin phosphorylation cascade 15 1.43e-01 -2.18e-01 3.00e-01
Signaling by ALK 18 1.09e-01 -2.18e-01 2.48e-01
Switching of origins to a post-replicative state 81 7.23e-04 -2.17e-01 6.21e-03
RNA Polymerase III Abortive And Retractive Initiation 39 1.91e-02 -2.17e-01 6.74e-02
RNA Polymerase III Transcription 39 1.91e-02 -2.17e-01 6.74e-02
Deubiquitination 198 1.54e-07 -2.17e-01 1.24e-05
Apoptosis 133 1.76e-05 -2.16e-01 5.53e-04
Regulation of actin dynamics for phagocytic cup formation 44 1.33e-02 -2.16e-01 5.18e-02
Formation of a pool of free 40S subunits 78 1.01e-03 -2.16e-01 8.08e-03
Activated NOTCH1 Transmits Signal to the Nucleus 19 1.04e-01 -2.15e-01 2.40e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 48 1.03e-02 -2.14e-01 4.42e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 77 1.17e-03 -2.14e-01 8.84e-03
Prostacyclin signalling through prostacyclin receptor 12 1.99e-01 2.14e-01 3.71e-01
Eukaryotic Translation Termination 72 1.75e-03 -2.14e-01 1.21e-02
Regulation of TNFR1 signaling 31 3.97e-02 -2.13e-01 1.18e-01
Regulation of TP53 Activity 136 1.81e-05 -2.13e-01 5.53e-04
Transport of Ribonucleoproteins into the Host Nucleus 30 4.35e-02 -2.13e-01 1.27e-01
Mitochondrial tRNA aminoacylation 18 1.18e-01 -2.13e-01 2.61e-01
DNA Replication 113 9.53e-05 -2.13e-01 1.36e-03
RNA polymerase II transcribes snRNA genes 71 1.96e-03 -2.13e-01 1.30e-02
Peptide chain elongation 69 2.34e-03 -2.12e-01 1.45e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 2.04e-01 -2.12e-01 3.76e-01
Negative regulation of FLT3 13 1.86e-01 -2.12e-01 3.62e-01
Eukaryotic Translation Elongation 72 1.94e-03 -2.11e-01 1.30e-02
Cap-dependent Translation Initiation 95 3.89e-04 -2.11e-01 3.81e-03
Eukaryotic Translation Initiation 95 3.89e-04 -2.11e-01 3.81e-03
TNF signaling 38 2.51e-02 -2.10e-01 8.29e-02
Plasma lipoprotein clearance 24 7.50e-02 -2.10e-01 1.91e-01
Metal ion SLC transporters 16 1.46e-01 -2.10e-01 3.04e-01
ADP signalling through P2Y purinoceptor 1 16 1.47e-01 2.09e-01 3.04e-01
C-type lectin receptors (CLRs) 100 3.06e-04 -2.09e-01 3.17e-03
APC/C-mediated degradation of cell cycle proteins 77 1.56e-03 -2.09e-01 1.09e-02
Regulation of mitotic cell cycle 77 1.56e-03 -2.09e-01 1.09e-02
PIWI-interacting RNA (piRNA) biogenesis 16 1.50e-01 -2.08e-01 3.08e-01
PRC2 methylates histones and DNA 12 2.14e-01 -2.07e-01 3.92e-01
tRNA processing in the nucleus 55 7.99e-03 -2.07e-01 3.61e-02
Defective pyroptosis 10 2.58e-01 -2.07e-01 4.52e-01
Influenza Infection 130 4.98e-05 -2.06e-01 8.68e-04
Nucleotide salvage 18 1.30e-01 -2.06e-01 2.80e-01
CTNNB1 S33 mutants aren’t phosphorylated 13 1.98e-01 -2.06e-01 3.70e-01
CTNNB1 S37 mutants aren’t phosphorylated 13 1.98e-01 -2.06e-01 3.70e-01
CTNNB1 S45 mutants aren’t phosphorylated 13 1.98e-01 -2.06e-01 3.70e-01
CTNNB1 T41 mutants aren’t phosphorylated 13 1.98e-01 -2.06e-01 3.70e-01
Signaling by CTNNB1 phospho-site mutants 13 1.98e-01 -2.06e-01 3.70e-01
Signaling by GSK3beta mutants 13 1.98e-01 -2.06e-01 3.70e-01
Diseases associated with glycosylation precursor biosynthesis 15 1.70e-01 -2.04e-01 3.40e-01
SUMO E3 ligases SUMOylate target proteins 132 5.47e-05 -2.04e-01 9.19e-04
Hedgehog ‘on’ state 63 5.22e-03 -2.04e-01 2.63e-02
Platelet calcium homeostasis 17 1.46e-01 -2.04e-01 3.04e-01
Metalloprotease DUBs 17 1.46e-01 -2.04e-01 3.04e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 88 9.86e-04 -2.03e-01 8.01e-03
SUMOylation of intracellular receptors 19 1.25e-01 -2.03e-01 2.72e-01
Ion transport by P-type ATPases 27 6.74e-02 -2.03e-01 1.77e-01
SUMOylation of RNA binding proteins 42 2.37e-02 -2.02e-01 8.02e-02
Striated Muscle Contraction 10 2.71e-01 -2.01e-01 4.69e-01
Selenocysteine synthesis 70 3.76e-03 -2.00e-01 2.07e-02
Deposition of new CENPA-containing nucleosomes at the centromere 23 9.67e-02 -2.00e-01 2.26e-01
Nucleosome assembly 23 9.67e-02 -2.00e-01 2.26e-01
COPI-mediated anterograde transport 71 3.58e-03 -2.00e-01 2.00e-02
SUMOylation of immune response proteins 10 2.76e-01 -1.99e-01 4.73e-01
PCP/CE pathway 71 3.82e-03 -1.99e-01 2.09e-02
Glucagon-type ligand receptors 14 1.99e-01 1.98e-01 3.70e-01
Regulation of IFNG signaling 13 2.16e-01 1.98e-01 3.94e-01
Selenoamino acid metabolism 78 2.50e-03 -1.98e-01 1.52e-02
APC/C:Cdc20 mediated degradation of Cyclin B 22 1.08e-01 -1.98e-01 2.47e-01
SUMOylation of DNA damage response and repair proteins 67 5.15e-03 -1.98e-01 2.60e-02
G2/M Checkpoints 119 2.08e-04 -1.97e-01 2.32e-03
SRP-dependent cotranslational protein targeting to membrane 88 1.42e-03 -1.97e-01 1.03e-02
RNA Polymerase I Promoter Escape 27 7.71e-02 -1.97e-01 1.95e-01
Interleukin-1 family signaling 99 7.75e-04 -1.96e-01 6.56e-03
Synthesis of PC 22 1.12e-01 -1.96e-01 2.53e-01
RNA Polymerase I Promoter Clearance 44 2.52e-02 -1.95e-01 8.29e-02
RNA Polymerase I Transcription 44 2.52e-02 -1.95e-01 8.29e-02
Role of phospholipids in phagocytosis 16 1.77e-01 -1.95e-01 3.47e-01
RUNX3 regulates NOTCH signaling 11 2.64e-01 -1.95e-01 4.60e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 83 2.22e-03 -1.94e-01 1.40e-02
COPI-independent Golgi-to-ER retrograde traffic 29 7.01e-02 -1.94e-01 1.83e-01
Mitotic Anaphase 195 3.07e-06 -1.94e-01 1.48e-04
Mitotic Metaphase and Anaphase 196 3.05e-06 -1.94e-01 1.48e-04
Signalling to RAS 12 2.45e-01 -1.94e-01 4.37e-01
NOTCH1 Intracellular Domain Regulates Transcription 37 4.23e-02 -1.93e-01 1.24e-01
Respiratory electron transport 82 2.63e-03 -1.92e-01 1.58e-02
RHOBTB1 GTPase cycle 18 1.58e-01 -1.92e-01 3.20e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 24 1.03e-01 -1.92e-01 2.39e-01
Inwardly rectifying K+ channels 13 2.31e-01 1.92e-01 4.17e-01
Cargo concentration in the ER 20 1.38e-01 -1.92e-01 2.93e-01
HCMV Infection 71 5.32e-03 -1.91e-01 2.66e-02
NOTCH4 Intracellular Domain Regulates Transcription 14 2.15e-01 -1.91e-01 3.93e-01
Signaling by ERBB2 KD Mutants 12 2.53e-01 -1.91e-01 4.47e-01
GPCR ligand binding 80 3.28e-03 1.90e-01 1.87e-02
L13a-mediated translational silencing of Ceruloplasmin expression 87 2.17e-03 -1.90e-01 1.39e-02
Cellular response to chemical stress 145 7.95e-05 -1.90e-01 1.18e-03
Hedgehog ‘off’ state 75 4.43e-03 -1.90e-01 2.35e-02
TP53 Regulates Transcription of Cell Cycle Genes 43 3.13e-02 -1.90e-01 9.81e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 45 2.77e-02 -1.90e-01 8.92e-02
Diseases of mitotic cell cycle 34 5.57e-02 -1.90e-01 1.56e-01
Intrinsic Pathway for Apoptosis 47 2.47e-02 -1.89e-01 8.21e-02
TRAF3-dependent IRF activation pathway 14 2.21e-01 -1.89e-01 4.00e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 78 3.94e-03 -1.89e-01 2.14e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 88 2.24e-03 -1.89e-01 1.40e-02
Nonsense-Mediated Decay (NMD) 88 2.24e-03 -1.89e-01 1.40e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression 16 1.93e-01 -1.88e-01 3.69e-01
Diseases associated with O-glycosylation of proteins 21 1.36e-01 1.88e-01 2.90e-01
Synthesis of PIPs at the early endosome membrane 12 2.60e-01 -1.88e-01 4.55e-01
SUMOylation 138 1.46e-04 -1.88e-01 1.77e-03
Death Receptor Signalling 96 1.52e-03 -1.87e-01 1.08e-02
RHO GTPases activate CIT 14 2.25e-01 -1.87e-01 4.06e-01
TAK1-dependent IKK and NF-kappa-B activation 18 1.70e-01 -1.87e-01 3.39e-01
APC-Cdc20 mediated degradation of Nek2A 24 1.13e-01 -1.87e-01 2.54e-01
Nuclear Pore Complex (NPC) Disassembly 34 6.01e-02 -1.86e-01 1.63e-01
Telomere C-strand (Lagging Strand) Synthesis 29 8.26e-02 -1.86e-01 2.01e-01
RHO GTPase Effectors 188 1.13e-05 -1.86e-01 4.11e-04
Chromosome Maintenance 78 4.52e-03 -1.86e-01 2.35e-02
Gap junction trafficking 10 3.09e-01 1.86e-01 5.04e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 3.10e-01 -1.85e-01 5.05e-01
ERKs are inactivated 11 2.88e-01 -1.85e-01 4.83e-01
Glycogen storage diseases 10 3.11e-01 -1.85e-01 5.05e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 2.88e-01 1.85e-01 4.84e-01
Signaling by the B Cell Receptor (BCR) 90 2.48e-03 -1.85e-01 1.52e-02
RIP-mediated NFkB activation via ZBP1 14 2.31e-01 -1.85e-01 4.17e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 55 1.81e-02 -1.84e-01 6.51e-02
Regulation of TP53 Activity through Methylation 17 1.89e-01 -1.84e-01 3.65e-01
Translation 238 1.22e-06 -1.83e-01 7.32e-05
Mitochondrial translation 89 2.87e-03 -1.83e-01 1.64e-02
Mitochondrial translation initiation 84 3.78e-03 -1.83e-01 2.08e-02
Major pathway of rRNA processing in the nucleolus and cytosol 152 1.04e-04 -1.83e-01 1.40e-03
NGF-stimulated transcription 25 1.15e-01 -1.82e-01 2.56e-01
Formation of the ternary complex, and subsequently, the 43S complex 40 4.62e-02 -1.82e-01 1.34e-01
Signaling by NOTCH1 51 2.45e-02 -1.82e-01 8.21e-02
Downregulation of ERBB2 signaling 17 1.94e-01 -1.82e-01 3.70e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 58 1.67e-02 -1.82e-01 6.19e-02
Resolution of Sister Chromatid Cohesion 92 2.71e-03 -1.81e-01 1.58e-02
G2/M DNA damage checkpoint 54 2.17e-02 -1.81e-01 7.43e-02
TCR signaling 87 3.63e-03 -1.81e-01 2.02e-02
rRNA processing 164 6.91e-05 -1.81e-01 1.05e-03
Programmed Cell Death 155 1.12e-04 -1.80e-01 1.43e-03
Transport of Mature Transcript to Cytoplasm 64 1.30e-02 -1.80e-01 5.11e-02
Mitochondrial translation termination 83 4.72e-03 -1.80e-01 2.42e-02
ABC transporters in lipid homeostasis 10 3.27e-01 1.79e-01 5.24e-01
M Phase 297 1.31e-07 -1.79e-01 1.14e-05
Translation of Replicase and Assembly of the Replication Transcription Complex 11 3.05e-01 -1.79e-01 4.99e-01
Pyruvate metabolism 20 1.67e-01 -1.79e-01 3.33e-01
BBSome-mediated cargo-targeting to cilium 19 1.79e-01 -1.78e-01 3.50e-01
Cell Cycle Checkpoints 228 4.00e-06 -1.78e-01 1.60e-04
PTEN Regulation 115 1.00e-03 -1.78e-01 8.08e-03
Regulated Necrosis 43 4.41e-02 -1.78e-01 1.28e-01
Golgi-to-ER retrograde transport 95 2.82e-03 -1.78e-01 1.62e-02
p75 NTR receptor-mediated signalling 59 1.85e-02 -1.77e-01 6.60e-02
Transcriptional Regulation by TP53 302 1.33e-07 -1.77e-01 1.14e-05
Fcgamma receptor (FCGR) dependent phagocytosis 62 1.60e-02 -1.77e-01 5.98e-02
RHO GTPases Activate Formins 102 2.08e-03 -1.77e-01 1.35e-02
tRNA Aminoacylation 23 1.43e-01 -1.77e-01 3.00e-01
RMTs methylate histone arginines 25 1.27e-01 -1.76e-01 2.77e-01
Telomere Maintenance 57 2.25e-02 -1.75e-01 7.63e-02
Signaling by NOTCH 135 4.75e-04 -1.75e-01 4.53e-03
rRNA processing in the nucleus and cytosol 159 1.54e-04 -1.74e-01 1.85e-03
Fc epsilon receptor (FCERI) signaling 107 1.88e-03 -1.74e-01 1.27e-02
Estrogen-dependent gene expression 70 1.19e-02 -1.74e-01 4.84e-02
ABC-family proteins mediated transport 74 9.80e-03 -1.74e-01 4.27e-02
Transcriptional regulation by RUNX2 84 5.96e-03 -1.74e-01 2.96e-02
Recruitment of NuMA to mitotic centrosomes 65 1.56e-02 -1.74e-01 5.88e-02
APC truncation mutants have impaired AXIN binding 12 2.99e-01 -1.73e-01 4.92e-01
AXIN missense mutants destabilize the destruction complex 12 2.99e-01 -1.73e-01 4.92e-01
Signaling by AMER1 mutants 12 2.99e-01 -1.73e-01 4.92e-01
Signaling by APC mutants 12 2.99e-01 -1.73e-01 4.92e-01
Signaling by AXIN mutants 12 2.99e-01 -1.73e-01 4.92e-01
Truncations of AMER1 destabilize the destruction complex 12 2.99e-01 -1.73e-01 4.92e-01
Aquaporin-mediated transport 25 1.34e-01 1.73e-01 2.88e-01
Senescence-Associated Secretory Phenotype (SASP) 42 5.24e-02 -1.73e-01 1.48e-01
Elastic fibre formation 17 2.20e-01 1.72e-01 4.00e-01
Glucose metabolism 72 1.22e-02 -1.71e-01 4.90e-02
Cell Cycle, Mitotic 425 2.02e-09 -1.71e-01 2.94e-07
Gap junction trafficking and regulation 11 3.29e-01 1.70e-01 5.26e-01
Metabolism of non-coding RNA 48 4.18e-02 -1.70e-01 1.24e-01
snRNP Assembly 48 4.18e-02 -1.70e-01 1.24e-01
Signaling by ERBB2 33 9.13e-02 -1.70e-01 2.17e-01
COPI-dependent Golgi-to-ER retrograde traffic 66 1.75e-02 -1.69e-01 6.36e-02
Cilium Assembly 150 3.73e-04 -1.69e-01 3.74e-03
Nicotinamide salvaging 11 3.33e-01 1.68e-01 5.30e-01
MicroRNA (miRNA) biogenesis 21 1.82e-01 -1.68e-01 3.55e-01
SUMOylation of DNA replication proteins 43 5.67e-02 -1.68e-01 1.56e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 2.60e-01 -1.68e-01 4.55e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 158 2.88e-04 -1.68e-01 3.01e-03
HDR through MMEJ (alt-NHEJ) 11 3.37e-01 -1.67e-01 5.33e-01
NS1 Mediated Effects on Host Pathways 38 7.49e-02 -1.67e-01 1.91e-01
Epigenetic regulation of gene expression 76 1.21e-02 -1.67e-01 4.87e-02
Metabolism of RNA 553 3.20e-11 -1.67e-01 9.60e-09
Deadenylation-dependent mRNA decay 52 3.78e-02 -1.67e-01 1.15e-01
Mitotic Prometaphase 158 3.20e-04 -1.66e-01 3.29e-03
Aberrant regulation of mitotic cell cycle due to RB1 defects 33 9.89e-02 -1.66e-01 2.30e-01
Gene Silencing by RNA 62 2.41e-02 -1.66e-01 8.09e-02
RNA Polymerase III Transcription Initiation 35 9.05e-02 -1.65e-01 2.17e-01
ABC transporter disorders 59 2.83e-02 -1.65e-01 9.04e-02
Beta-catenin independent WNT signaling 106 3.42e-03 -1.65e-01 1.93e-02
Post-chaperonin tubulin folding pathway 13 3.05e-01 1.64e-01 5.00e-01
G-protein mediated events 32 1.09e-01 -1.64e-01 2.48e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 88 8.32e-03 -1.63e-01 3.73e-02
ZBP1(DAI) mediated induction of type I IFNs 17 2.45e-01 -1.63e-01 4.37e-01
Mitochondrial iron-sulfur cluster biogenesis 12 3.29e-01 -1.63e-01 5.26e-01
Signaling by TGF-beta Receptor Complex 72 1.76e-02 -1.62e-01 6.36e-02
Signaling by FGFR in disease 39 8.08e-02 -1.62e-01 2.00e-01
Signaling by MET 41 7.35e-02 -1.62e-01 1.89e-01
Degradation of cysteine and homocysteine 10 3.77e-01 -1.61e-01 5.71e-01
Plasma lipoprotein assembly, remodeling, and clearance 39 8.14e-02 -1.61e-01 2.00e-01
Regulation of beta-cell development 16 2.64e-01 -1.61e-01 4.60e-01
TCF dependent signaling in response to WNT 119 2.45e-03 -1.61e-01 1.50e-02
Cytosolic sensors of pathogen-associated DNA 53 4.28e-02 -1.61e-01 1.25e-01
tRNA processing 93 7.38e-03 -1.61e-01 3.44e-02
RHOH GTPase cycle 29 1.36e-01 -1.60e-01 2.90e-01
Processing of Capped Intron-Containing Pre-mRNA 199 1.07e-04 -1.60e-01 1.40e-03
Interleukin-37 signaling 17 2.56e-01 1.59e-01 4.49e-01
Base-Excision Repair, AP Site Formation 15 2.87e-01 -1.59e-01 4.83e-01
Organelle biogenesis and maintenance 204 9.71e-05 -1.59e-01 1.37e-03
Thromboxane signalling through TP receptor 15 2.88e-01 1.59e-01 4.83e-01
Glycolysis 57 3.94e-02 -1.58e-01 1.18e-01
RHO GTPases Activate ROCKs 13 3.26e-01 -1.57e-01 5.23e-01
Cell Cycle 530 8.55e-10 -1.57e-01 1.47e-07
RHO GTPases activate PAKs 13 3.27e-01 -1.57e-01 5.24e-01
Activation of gene expression by SREBF (SREBP) 36 1.04e-01 -1.57e-01 2.40e-01
Deadenylation of mRNA 23 1.94e-01 -1.56e-01 3.70e-01
TNFR2 non-canonical NF-kB pathway 68 2.60e-02 -1.56e-01 8.48e-02
HATs acetylate histones 63 3.21e-02 -1.56e-01 1.00e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 2.53e-01 -1.56e-01 4.47e-01
Selective autophagy 50 5.75e-02 -1.55e-01 1.58e-01
SARS-CoV-2-host interactions 150 1.06e-03 -1.55e-01 8.15e-03
Gamma carboxylation, hypusine formation and arylsulfatase activation 23 1.98e-01 -1.55e-01 3.70e-01
PERK regulates gene expression 26 1.73e-01 -1.55e-01 3.42e-01
Signaling by TGFB family members 85 1.47e-02 -1.53e-01 5.63e-02
Retrograde transport at the Trans-Golgi-Network 45 7.55e-02 -1.53e-01 1.92e-01
Negative epigenetic regulation of rRNA expression 44 7.92e-02 -1.53e-01 1.98e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 19 2.48e-01 1.53e-01 4.41e-01
Transcriptional regulation by RUNX1 137 2.08e-03 -1.53e-01 1.35e-02
Signaling by FGFR2 48 6.75e-02 -1.53e-01 1.77e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 28 1.63e-01 -1.53e-01 3.27e-01
Sulfur amino acid metabolism 17 2.79e-01 -1.52e-01 4.76e-01
Diseases associated with glycosaminoglycan metabolism 16 2.94e-01 -1.52e-01 4.92e-01
FCGR3A-mediated phagocytosis 42 8.98e-02 -1.51e-01 2.15e-01
Leishmania phagocytosis 42 8.98e-02 -1.51e-01 2.15e-01
Parasite infection 42 8.98e-02 -1.51e-01 2.15e-01
Mitotic Spindle Checkpoint 98 9.87e-03 -1.51e-01 4.28e-02
MHC class II antigen presentation 69 3.02e-02 -1.51e-01 9.56e-02
Transcriptional regulation of white adipocyte differentiation 56 5.08e-02 -1.51e-01 1.44e-01
Cellular response to starvation 120 4.37e-03 -1.51e-01 2.32e-02
Ribosomal scanning and start codon recognition 47 7.38e-02 -1.51e-01 1.89e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 83 1.77e-02 -1.51e-01 6.36e-02
Amplification of signal from the kinetochores 83 1.77e-02 -1.51e-01 6.36e-02
Centrosome maturation 66 3.49e-02 -1.50e-01 1.08e-01
Recruitment of mitotic centrosome proteins and complexes 66 3.49e-02 -1.50e-01 1.08e-01
Detoxification of Reactive Oxygen Species 23 2.13e-01 1.50e-01 3.91e-01
LDL clearance 12 3.70e-01 -1.50e-01 5.66e-01
Processive synthesis on the C-strand of the telomere 17 2.87e-01 -1.49e-01 4.83e-01
Complex I biogenesis 43 9.12e-02 -1.49e-01 2.17e-01
Signaling by PDGF 25 1.98e-01 1.49e-01 3.70e-01
CD28 dependent PI3K/Akt signaling 18 2.74e-01 -1.49e-01 4.70e-01
Interleukin-35 Signalling 11 3.93e-01 -1.49e-01 5.82e-01
GAB1 signalosome 10 4.15e-01 -1.49e-01 6.06e-01
Mitochondrial translation elongation 84 1.92e-02 -1.48e-01 6.74e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 61 4.63e-02 -1.48e-01 1.34e-01
Cargo trafficking to the periciliary membrane 40 1.08e-01 -1.47e-01 2.47e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 39 1.12e-01 -1.47e-01 2.53e-01
Regulation of PLK1 Activity at G2/M Transition 74 2.93e-02 -1.47e-01 9.30e-02
Membrane binding and targetting of GAG proteins 12 3.80e-01 -1.46e-01 5.71e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 3.80e-01 -1.46e-01 5.71e-01
Nuclear Envelope (NE) Reassembly 60 5.04e-02 -1.46e-01 1.44e-01
G alpha (q) signalling events 78 2.59e-02 1.46e-01 8.48e-02
G beta:gamma signalling through BTK 11 4.02e-01 1.46e-01 5.89e-01
Mitotic G2-G2/M phases 158 1.60e-03 -1.46e-01 1.11e-02
Signaling by cytosolic FGFR1 fusion mutants 16 3.13e-01 -1.46e-01 5.07e-01
IKK complex recruitment mediated by RIP1 17 2.98e-01 -1.46e-01 4.92e-01
G2/M Transition 156 1.86e-03 -1.45e-01 1.26e-02
STING mediated induction of host immune responses 10 4.30e-01 1.44e-01 6.15e-01
Ion homeostasis 26 2.04e-01 -1.44e-01 3.77e-01
Synthesis of very long-chain fatty acyl-CoAs 16 3.21e-01 1.43e-01 5.19e-01
Resolution of D-Loop Structures 29 1.84e-01 -1.43e-01 3.58e-01
Azathioprine ADME 15 3.40e-01 -1.42e-01 5.36e-01
EPHB-mediated forward signaling 25 2.19e-01 -1.42e-01 3.98e-01
HCMV Late Events 51 7.97e-02 -1.42e-01 1.98e-01
Infectious disease 627 2.20e-09 -1.42e-01 2.94e-07
Glucagon signaling in metabolic regulation 18 2.99e-01 1.41e-01 4.92e-01
Signaling by NTRK3 (TRKC) 11 4.17e-01 -1.41e-01 6.07e-01
VEGFA-VEGFR2 Pathway 71 3.97e-02 -1.41e-01 1.18e-01
Formation of Incision Complex in GG-NER 36 1.43e-01 -1.41e-01 3.00e-01
RHOBTB GTPase Cycle 29 1.90e-01 -1.41e-01 3.65e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 12 3.99e-01 1.41e-01 5.87e-01
Response to elevated platelet cytosolic Ca2+ 53 7.76e-02 -1.40e-01 1.95e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 35 1.54e-01 1.39e-01 3.15e-01
The citric acid (TCA) cycle and respiratory electron transport 121 8.30e-03 -1.39e-01 3.73e-02
SARS-CoV-2 modulates host translation machinery 39 1.35e-01 -1.39e-01 2.88e-01
CTLA4 inhibitory signaling 16 3.37e-01 1.39e-01 5.33e-01
Signaling by WNT 177 1.55e-03 -1.38e-01 1.09e-02
Interleukin-7 signaling 14 3.71e-01 -1.38e-01 5.66e-01
Purine catabolism 10 4.50e-01 -1.38e-01 6.33e-01
ESR-mediated signaling 115 1.10e-02 -1.38e-01 4.60e-02
Keratan sulfate biosynthesis 14 3.73e-01 -1.37e-01 5.68e-01
Regulation of TP53 Activity through Acetylation 27 2.17e-01 -1.37e-01 3.95e-01
CD28 co-stimulation 27 2.17e-01 -1.37e-01 3.96e-01
RUNX2 regulates osteoblast differentiation 13 3.94e-01 -1.37e-01 5.82e-01
Recycling pathway of L1 15 3.61e-01 1.36e-01 5.58e-01
Signaling by BMP 15 3.62e-01 1.36e-01 5.58e-01
Generic Transcription Pathway 826 6.43e-11 -1.36e-01 1.55e-08
mRNA Splicing - Major Pathway 148 4.46e-03 -1.36e-01 2.35e-02
Initiation of Nuclear Envelope (NE) Reformation 17 3.34e-01 -1.35e-01 5.30e-01
TGF-beta receptor signaling activates SMADs 39 1.44e-01 -1.35e-01 3.01e-01
Signaling by FGFR 52 9.20e-02 -1.35e-01 2.18e-01
MET promotes cell motility 13 3.99e-01 -1.35e-01 5.87e-01
RAB geranylgeranylation 40 1.40e-01 -1.35e-01 2.95e-01
Signaling by FLT3 ITD and TKD mutants 12 4.19e-01 -1.35e-01 6.08e-01
N-Glycan antennae elongation 10 4.60e-01 1.35e-01 6.44e-01
Circadian Clock 52 9.33e-02 -1.35e-01 2.20e-01
Gene expression (Transcription) 1040 6.43e-13 -1.35e-01 4.16e-10
Translation initiation complex formation 47 1.13e-01 -1.34e-01 2.53e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 3.13e-01 -1.34e-01 5.07e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 3.13e-01 -1.34e-01 5.07e-01
VEGFR2 mediated cell proliferation 16 3.54e-01 -1.34e-01 5.52e-01
SUMOylation of transcription cofactors 35 1.72e-01 -1.33e-01 3.41e-01
Cleavage of the damaged pyrimidine 14 3.88e-01 -1.33e-01 5.78e-01
Depyrimidination 14 3.88e-01 -1.33e-01 5.78e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 14 3.88e-01 -1.33e-01 5.78e-01
Diseases of glycosylation 69 5.65e-02 -1.33e-01 1.56e-01
Apoptotic execution phase 33 1.87e-01 -1.33e-01 3.63e-01
Signaling by Retinoic Acid 17 3.44e-01 -1.33e-01 5.39e-01
Activation of G protein gated Potassium channels 12 4.27e-01 1.33e-01 6.13e-01
G protein gated Potassium channels 12 4.27e-01 1.33e-01 6.13e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 12 4.27e-01 1.33e-01 6.13e-01
Nuclear Envelope Breakdown 49 1.09e-01 -1.32e-01 2.48e-01
mRNA Splicing 158 4.20e-03 -1.32e-01 2.24e-02
Maturation of nucleoprotein 11 4.48e-01 1.32e-01 6.31e-01
Insulin processing 17 3.45e-01 -1.32e-01 5.40e-01
NoRC negatively regulates rRNA expression 42 1.40e-01 -1.32e-01 2.95e-01
Insulin receptor recycling 17 3.47e-01 -1.32e-01 5.42e-01
Disease 1086 6.92e-13 -1.32e-01 4.16e-10
SUMOylation of chromatin organization proteins 49 1.11e-01 -1.32e-01 2.52e-01
Signaling by ERBB2 in Cancer 13 4.14e-01 -1.31e-01 6.04e-01
Vasopressin regulates renal water homeostasis via Aquaporins 23 2.78e-01 1.31e-01 4.76e-01
Chaperonin-mediated protein folding 57 8.83e-02 -1.31e-01 2.14e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 16 3.67e-01 -1.30e-01 5.63e-01
Extension of Telomeres 44 1.36e-01 -1.30e-01 2.90e-01
Interleukin-4 and Interleukin-13 signaling 49 1.16e-01 -1.30e-01 2.57e-01
NCAM signaling for neurite out-growth 24 2.71e-01 1.30e-01 4.69e-01
Retinoid metabolism and transport 11 4.57e-01 -1.29e-01 6.41e-01
Synthesis of PA 18 3.43e-01 1.29e-01 5.39e-01
Unwinding of DNA 11 4.60e-01 -1.29e-01 6.44e-01
Ca2+ pathway 40 1.61e-01 -1.28e-01 3.25e-01
Polymerase switching on the C-strand of the telomere 22 2.99e-01 -1.28e-01 4.92e-01
Mitochondrial biogenesis 54 1.05e-01 -1.28e-01 2.42e-01
Nonhomologous End-Joining (NHEJ) 29 2.36e-01 -1.27e-01 4.24e-01
Iron uptake and transport 38 1.75e-01 -1.27e-01 3.44e-01
Diseases of signal transduction by growth factor receptors and second messengers 299 1.69e-04 -1.27e-01 1.99e-03
Signaling by ERBB4 31 2.21e-01 -1.27e-01 4.00e-01
Disorders of transmembrane transporters 111 2.15e-02 -1.26e-01 7.39e-02
Adrenaline,noradrenaline inhibits insulin secretion 15 3.98e-01 1.26e-01 5.86e-01
ROS and RNS production in phagocytes 23 2.96e-01 -1.26e-01 4.92e-01
Signaling by VEGF 73 6.37e-02 -1.26e-01 1.70e-01
SHC1 events in ERBB2 signaling 11 4.72e-01 1.25e-01 6.55e-01
Cytochrome P450 - arranged by substrate type 14 4.17e-01 1.25e-01 6.07e-01
RNA Polymerase II Transcription 927 2.19e-10 -1.25e-01 4.40e-08
Formation of tubulin folding intermediates by CCT/TriC 14 4.20e-01 -1.25e-01 6.08e-01
ISG15 antiviral mechanism 70 7.25e-02 -1.24e-01 1.88e-01
ER to Golgi Anterograde Transport 108 2.62e-02 -1.24e-01 8.54e-02
Oncogene Induced Senescence 30 2.41e-01 -1.24e-01 4.33e-01
MAP2K and MAPK activation 25 2.85e-01 1.24e-01 4.83e-01
Cellular responses to stress 546 1.03e-06 -1.23e-01 6.52e-05
Nicotinate metabolism 19 3.52e-01 1.23e-01 5.48e-01
Mucopolysaccharidoses 10 5.00e-01 1.23e-01 6.80e-01
Ion channel transport 80 5.71e-02 -1.23e-01 1.57e-01
RND1 GTPase cycle 29 2.52e-01 -1.23e-01 4.45e-01
MyD88 dependent cascade initiated on endosome 67 8.27e-02 -1.23e-01 2.01e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 67 8.27e-02 -1.23e-01 2.01e-01
TNFR1-induced NFkappaB signaling pathway 20 3.42e-01 -1.23e-01 5.39e-01
SARS-CoV-2 Infection 213 2.18e-03 -1.22e-01 1.39e-02
Metabolism of water-soluble vitamins and cofactors 82 5.59e-02 -1.22e-01 1.56e-01
Activation of ATR in response to replication stress 36 2.07e-01 -1.22e-01 3.80e-01
Nuclear Events (kinase and transcription factor activation) 42 1.73e-01 -1.21e-01 3.44e-01
EML4 and NUDC in mitotic spindle formation 87 5.06e-02 -1.21e-01 1.44e-01
G alpha (z) signalling events 25 2.94e-01 1.21e-01 4.92e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 48 1.47e-01 -1.21e-01 3.04e-01
Cellular responses to stimuli 551 1.49e-06 -1.21e-01 8.53e-05
Inhibition of replication initiation of damaged DNA by RB1/E2F1 10 5.08e-01 -1.21e-01 6.88e-01
Platelet degranulation 49 1.44e-01 -1.21e-01 3.00e-01
TICAM1, RIP1-mediated IKK complex recruitment 17 3.91e-01 -1.20e-01 5.81e-01
Suppression of phagosomal maturation 12 4.72e-01 -1.20e-01 6.55e-01
Collagen biosynthesis and modifying enzymes 19 3.66e-01 1.20e-01 5.62e-01
Cell death signalling via NRAGE, NRIF and NADE 45 1.65e-01 -1.20e-01 3.32e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 16 4.08e-01 -1.19e-01 5.97e-01
Thrombin signalling through proteinase activated receptors (PARs) 20 3.57e-01 1.19e-01 5.52e-01
Basigin interactions 14 4.41e-01 1.19e-01 6.26e-01
Zinc transporters 12 4.76e-01 -1.19e-01 6.59e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 23 3.25e-01 1.18e-01 5.23e-01
Cellular response to heat stress 80 6.74e-02 -1.18e-01 1.77e-01
Nuclear Receptor transcription pathway 27 2.87e-01 -1.18e-01 4.83e-01
Regulation of HSF1-mediated heat shock response 67 9.47e-02 -1.18e-01 2.22e-01
PLC beta mediated events 29 2.74e-01 -1.17e-01 4.70e-01
SUMOylation of transcription factors 13 4.64e-01 -1.17e-01 6.48e-01
Transcriptional activation of mitochondrial biogenesis 40 2.00e-01 -1.17e-01 3.71e-01
Spry regulation of FGF signaling 15 4.32e-01 -1.17e-01 6.16e-01
Transferrin endocytosis and recycling 19 3.79e-01 -1.17e-01 5.71e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 33 2.46e-01 -1.17e-01 4.39e-01
Activation of the pre-replicative complex 30 2.69e-01 -1.17e-01 4.68e-01
Factors involved in megakaryocyte development and platelet production 87 6.10e-02 -1.16e-01 1.64e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 14 4.52e-01 -1.16e-01 6.35e-01
ATF4 activates genes in response to endoplasmic reticulum stress 23 3.36e-01 -1.16e-01 5.33e-01
NOTCH3 Intracellular Domain Regulates Transcription 15 4.37e-01 -1.16e-01 6.22e-01
NR1H2 and NR1H3-mediated signaling 27 2.98e-01 1.16e-01 4.92e-01
Cyclin D associated events in G1 41 2.00e-01 -1.16e-01 3.71e-01
G1 Phase 41 2.00e-01 -1.16e-01 3.71e-01
O-linked glycosylation 42 1.96e-01 1.15e-01 3.70e-01
Metabolism of proteins 1246 2.48e-11 -1.15e-01 9.60e-09
RNA Polymerase III Transcription Initiation From Type 3 Promoter 27 3.01e-01 -1.15e-01 4.94e-01
Metabolism of carbohydrates 181 7.95e-03 -1.15e-01 3.61e-02
Interleukin-12 family signaling 42 2.00e-01 -1.14e-01 3.71e-01
Post-translational protein phosphorylation 34 2.49e-01 1.14e-01 4.41e-01
Signaling by Hedgehog 99 4.98e-02 -1.14e-01 1.43e-01
RND3 GTPase cycle 29 2.88e-01 -1.14e-01 4.83e-01
Cell recruitment (pro-inflammatory response) 15 4.46e-01 1.14e-01 6.30e-01
Purinergic signaling in leishmaniasis infection 15 4.46e-01 1.14e-01 6.30e-01
Constitutive Signaling by Aberrant PI3K in Cancer 28 2.98e-01 1.14e-01 4.92e-01
Cargo recognition for clathrin-mediated endocytosis 63 1.20e-01 -1.13e-01 2.64e-01
Metabolism of amino acids and derivatives 225 3.65e-03 -1.13e-01 2.02e-02
Toll Like Receptor 9 (TLR9) Cascade 70 1.03e-01 -1.13e-01 2.39e-01
Kinesins 32 2.70e-01 -1.13e-01 4.69e-01
Mitotic Prophase 75 9.31e-02 -1.12e-01 2.20e-01
Chaperone Mediated Autophagy 12 5.01e-01 -1.12e-01 6.80e-01
Regulation of PTEN gene transcription 48 1.79e-01 -1.12e-01 3.50e-01
Erythropoietin activates RAS 10 5.40e-01 1.12e-01 7.17e-01
Myogenesis 13 4.86e-01 -1.12e-01 6.66e-01
MyD88 cascade initiated on plasma membrane 65 1.20e-01 -1.11e-01 2.65e-01
Toll Like Receptor 10 (TLR10) Cascade 65 1.20e-01 -1.11e-01 2.65e-01
Toll Like Receptor 5 (TLR5) Cascade 65 1.20e-01 -1.11e-01 2.65e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 10 5.42e-01 -1.11e-01 7.19e-01
InlB-mediated entry of Listeria monocytogenes into host cell 11 5.22e-01 -1.11e-01 7.02e-01
Transport to the Golgi and subsequent modification 130 2.88e-02 -1.11e-01 9.17e-02
Phase II - Conjugation of compounds 46 1.95e-01 -1.10e-01 3.70e-01
Protein folding 63 1.30e-01 -1.10e-01 2.82e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 66 1.23e-01 -1.10e-01 2.70e-01
Signaling by Non-Receptor Tyrosine Kinases 36 2.55e-01 -1.10e-01 4.49e-01
Signaling by PTK6 36 2.55e-01 -1.10e-01 4.49e-01
Signaling by Nuclear Receptors 151 2.05e-02 -1.10e-01 7.13e-02
Apoptotic cleavage of cellular proteins 25 3.45e-01 -1.09e-01 5.39e-01
Infection with Mycobacterium tuberculosis 22 3.77e-01 -1.09e-01 5.71e-01
RAF activation 28 3.22e-01 1.08e-01 5.19e-01
Axon guidance 300 1.38e-03 -1.08e-01 1.02e-02
Neddylation 188 1.12e-02 -1.08e-01 4.63e-02
Interleukin-12 signaling 36 2.64e-01 -1.08e-01 4.60e-01
DAP12 interactions 21 3.94e-01 -1.08e-01 5.82e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 14 4.86e-01 1.08e-01 6.66e-01
HSF1-dependent transactivation 25 3.58e-01 -1.06e-01 5.54e-01
Negative regulators of DDX58/IFIH1 signaling 34 2.85e-01 -1.06e-01 4.83e-01
Glutathione conjugation 21 4.01e-01 -1.06e-01 5.88e-01
Antiviral mechanism by IFN-stimulated genes 77 1.08e-01 -1.06e-01 2.48e-01
Degradation of the extracellular matrix 35 2.79e-01 1.06e-01 4.76e-01
VxPx cargo-targeting to cilium 16 4.65e-01 -1.05e-01 6.49e-01
GPCR downstream signalling 197 1.11e-02 1.05e-01 4.63e-02
Cell-cell junction organization 13 5.11e-01 1.05e-01 6.90e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 10 5.66e-01 1.05e-01 7.38e-01
Asparagine N-linked glycosylation 225 7.06e-03 -1.05e-01 3.32e-02
Plasma lipoprotein remodeling 11 5.51e-01 -1.04e-01 7.27e-01
Clathrin-mediated endocytosis 89 9.21e-02 -1.03e-01 2.18e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 33 3.06e-01 -1.03e-01 5.00e-01
Metabolism of vitamins and cofactors 111 6.25e-02 -1.03e-01 1.68e-01
TP53 Regulates Metabolic Genes 71 1.38e-01 -1.02e-01 2.92e-01
Diseases of programmed cell death 37 2.84e-01 -1.02e-01 4.83e-01
Integrin signaling 16 4.82e-01 -1.01e-01 6.65e-01
Platelet Aggregation (Plug Formation) 16 4.82e-01 -1.01e-01 6.65e-01
Pre-NOTCH Transcription and Translation 31 3.30e-01 -1.01e-01 5.26e-01
Translation of Structural Proteins 27 3.65e-01 -1.01e-01 5.61e-01
G alpha (12/13) signalling events 40 2.72e-01 1.00e-01 4.69e-01
Post-translational protein modification 917 4.18e-07 -1.00e-01 3.00e-05
Nervous system development 313 2.58e-03 -9.96e-02 1.56e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 16 4.91e-01 -9.95e-02 6.71e-01
Insulin receptor signalling cascade 26 3.82e-01 9.91e-02 5.72e-01
RHO GTPases activate PKNs 26 3.82e-01 -9.90e-02 5.72e-01
Activation of HOX genes during differentiation 41 2.74e-01 -9.89e-02 4.70e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 41 2.74e-01 -9.89e-02 4.70e-01
Amyloid fiber formation 27 3.74e-01 -9.88e-02 5.69e-01
HDMs demethylate histones 15 5.08e-01 -9.87e-02 6.88e-01
RHOV GTPase cycle 28 3.68e-01 -9.82e-02 5.65e-01
Uptake and actions of bacterial toxins 18 4.71e-01 9.82e-02 6.55e-01
Vesicle-mediated transport 454 4.02e-04 -9.77e-02 3.90e-03
G alpha (s) signalling events 48 2.42e-01 9.77e-02 4.33e-01
Diseases associated with the TLR signaling cascade 17 4.86e-01 -9.76e-02 6.66e-01
Diseases of Immune System 17 4.86e-01 -9.76e-02 6.66e-01
Toll Like Receptor 3 (TLR3) Cascade 74 1.48e-01 -9.75e-02 3.04e-01
KSRP (KHSRP) binds and destabilizes mRNA 15 5.14e-01 -9.72e-02 6.92e-01
Sensory processing of sound by outer hair cells of the cochlea 18 4.76e-01 -9.71e-02 6.59e-01
Membrane Trafficking 446 4.92e-04 -9.70e-02 4.66e-03
Signaling by Rho GTPases 437 5.62e-04 -9.70e-02 5.08e-03
Binding and Uptake of Ligands by Scavenger Receptors 10 5.95e-01 -9.70e-02 7.64e-01
Signaling by EGFR 35 3.22e-01 -9.67e-02 5.19e-01
PIP3 activates AKT signaling 185 2.41e-02 -9.64e-02 8.09e-02
PI3K Cascade 19 4.67e-01 9.63e-02 6.51e-01
VEGFR2 mediated vascular permeability 21 4.45e-01 -9.63e-02 6.30e-01
SARS-CoV Infections 270 6.77e-03 -9.62e-02 3.22e-02
PPARA activates gene expression 82 1.33e-01 -9.60e-02 2.86e-01
rRNA modification in the nucleus and cytosol 49 2.46e-01 -9.59e-02 4.38e-01
Class B/2 (Secretin family receptors) 29 3.73e-01 9.56e-02 5.68e-01
Signaling by Interleukins 265 7.66e-03 -9.56e-02 3.53e-02
Metabolism of nucleotides 73 1.59e-01 -9.55e-02 3.22e-01
Regulation of lipid metabolism by PPARalpha 84 1.31e-01 -9.54e-02 2.82e-01
MyD88-independent TLR4 cascade 74 1.58e-01 -9.51e-02 3.20e-01
TRIF(TICAM1)-mediated TLR4 signaling 74 1.58e-01 -9.51e-02 3.20e-01
Innate Immune System 620 6.42e-05 -9.51e-02 9.89e-04
Dopamine Neurotransmitter Release Cycle 12 5.68e-01 9.51e-02 7.39e-01
RUNX2 regulates bone development 18 4.86e-01 -9.48e-02 6.66e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 449 6.46e-04 -9.47e-02 5.63e-03
Transcriptional Regulation by MECP2 31 3.63e-01 -9.44e-02 5.59e-01
Intracellular signaling by second messengers 210 1.88e-02 -9.44e-02 6.69e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 71 1.75e-01 -9.32e-02 3.44e-01
Toll Like Receptor 2 (TLR2) Cascade 71 1.75e-01 -9.32e-02 3.44e-01
Toll Like Receptor TLR1:TLR2 Cascade 71 1.75e-01 -9.32e-02 3.44e-01
Toll Like Receptor TLR6:TLR2 Cascade 71 1.75e-01 -9.32e-02 3.44e-01
DNA Damage/Telomere Stress Induced Senescence 24 4.30e-01 -9.31e-02 6.15e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 35 3.44e-01 -9.25e-02 5.39e-01
NRAGE signals death through JNK 30 3.81e-01 9.24e-02 5.71e-01
activated TAK1 mediates p38 MAPK activation 13 5.66e-01 -9.19e-02 7.38e-01
Signaling by GPCR 216 2.12e-02 9.13e-02 7.33e-02
IRS-mediated signalling 21 4.69e-01 9.13e-02 6.53e-01
Macroautophagy 97 1.21e-01 -9.12e-02 2.66e-01
Extracellular matrix organization 93 1.29e-01 9.12e-02 2.80e-01
Diseases of metabolism 126 7.81e-02 -9.11e-02 1.96e-01
Triglyceride metabolism 16 5.30e-01 9.07e-02 7.09e-01
Josephin domain DUBs 11 6.03e-01 -9.07e-02 7.72e-01
Amino acid transport across the plasma membrane 16 5.30e-01 9.06e-02 7.09e-01
AKT phosphorylates targets in the cytosol 13 5.72e-01 -9.05e-02 7.41e-01
FLT3 Signaling 32 3.76e-01 -9.04e-02 5.71e-01
Other interleukin signaling 15 5.49e-01 -8.94e-02 7.25e-01
Drug ADME 27 4.24e-01 -8.90e-02 6.13e-01
EPH-Ephrin signaling 55 2.55e-01 -8.88e-02 4.49e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 45 3.03e-01 8.88e-02 4.97e-01
Signaling by Receptor Tyrosine Kinases 293 9.37e-03 -8.87e-02 4.16e-02
Intraflagellar transport 33 3.81e-01 -8.82e-02 5.71e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 22 4.79e-01 -8.71e-02 6.62e-01
Cellular Senescence 106 1.24e-01 -8.66e-02 2.70e-01
Developmental Biology 468 1.49e-03 -8.64e-02 1.07e-02
PI Metabolism 60 2.48e-01 -8.64e-02 4.40e-01
Signaling by ERBB2 TMD/JMD mutants 10 6.37e-01 -8.62e-02 8.04e-01
Chromatin modifying enzymes 158 6.26e-02 -8.61e-02 1.68e-01
Chromatin organization 158 6.26e-02 -8.61e-02 1.68e-01
Cell junction organization 26 4.48e-01 8.59e-02 6.32e-01
Interferon Signaling 142 7.96e-02 -8.54e-02 1.98e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 29 4.31e-01 -8.44e-02 6.16e-01
Intra-Golgi traffic 39 3.70e-01 -8.29e-02 5.66e-01
Phosphorylation of the APC/C 18 5.44e-01 -8.25e-02 7.22e-01
Class I MHC mediated antigen processing & presentation 289 1.64e-02 -8.25e-02 6.11e-02
Extra-nuclear estrogen signaling 49 3.22e-01 -8.19e-02 5.19e-01
mRNA decay by 3’ to 5’ exoribonuclease 14 5.96e-01 -8.18e-02 7.65e-01
TP53 Regulates Transcription of Cell Death Genes 31 4.31e-01 -8.17e-02 6.16e-01
SLC transporter disorders 52 3.10e-01 -8.14e-02 5.05e-01
FCERI mediated Ca+2 mobilization 23 5.00e-01 -8.12e-02 6.80e-01
Mitophagy 25 4.83e-01 -8.10e-02 6.66e-01
Constitutive Signaling by AKT1 E17K in Cancer 23 5.03e-01 -8.07e-02 6.82e-01
Response of Mtb to phagocytosis 20 5.34e-01 -8.04e-02 7.13e-01
Synthesis of substrates in N-glycan biosythesis 48 3.38e-01 -7.99e-02 5.34e-01
Nephrin family interactions 14 6.08e-01 7.91e-02 7.78e-01
Autophagy 106 1.61e-01 -7.89e-02 3.25e-01
Amino acids regulate mTORC1 42 3.79e-01 -7.84e-02 5.71e-01
Regulation of innate immune responses to cytosolic DNA 12 6.40e-01 -7.81e-02 8.04e-01
tRNA modification in the nucleus and cytosol 34 4.32e-01 -7.79e-02 6.16e-01
DNA Double Strand Break Response 36 4.20e-01 -7.76e-02 6.09e-01
Metabolism 1253 6.85e-06 -7.75e-02 2.66e-04
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 31 4.55e-01 7.75e-02 6.40e-01
G alpha (i) signalling events 93 1.98e-01 7.74e-02 3.70e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 5.71e-01 -7.71e-02 7.41e-01
Cytokine Signaling in Immune system 427 6.77e-03 -7.70e-02 3.22e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity 12 6.44e-01 7.70e-02 8.04e-01
Trafficking of AMPA receptors 12 6.44e-01 7.70e-02 8.04e-01
Assembly of collagen fibrils and other multimeric structures 14 6.21e-01 7.62e-02 7.90e-01
Toll Like Receptor 4 (TLR4) Cascade 94 2.02e-01 -7.62e-02 3.74e-01
mTORC1-mediated signalling 21 5.47e-01 7.59e-02 7.24e-01
Adaptive Immune System 481 4.71e-03 -7.59e-02 2.42e-02
RAC2 GTPase cycle 56 3.30e-01 -7.53e-02 5.26e-01
Signaling by ALK fusions and activated point mutants 46 3.78e-01 -7.52e-02 5.71e-01
Signaling by ALK in cancer 46 3.78e-01 -7.52e-02 5.71e-01
Signal amplification 20 5.61e-01 7.50e-02 7.36e-01
Oncogenic MAPK signaling 56 3.33e-01 7.49e-02 5.30e-01
Oxidative Stress Induced Senescence 55 3.37e-01 -7.48e-02 5.33e-01
DAG and IP3 signaling 26 5.09e-01 -7.48e-02 6.89e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 38 4.28e-01 -7.44e-02 6.13e-01
Regulation of KIT signaling 10 6.86e-01 7.38e-02 8.34e-01
Synthesis of IP3 and IP4 in the cytosol 16 6.12e-01 -7.33e-02 7.82e-01
Polo-like kinase mediated events 15 6.24e-01 -7.31e-02 7.92e-01
Immune System 1156 4.31e-05 -7.30e-02 8.51e-04
G-protein beta:gamma signalling 21 5.63e-01 -7.29e-02 7.37e-01
RAF-independent MAPK1/3 activation 20 5.74e-01 -7.27e-02 7.42e-01
Regulation of BACH1 activity 11 6.77e-01 7.25e-02 8.28e-01
Metabolism of fat-soluble vitamins 13 6.52e-01 -7.23e-02 8.09e-01
Condensation of Prophase Chromosomes 12 6.65e-01 -7.22e-02 8.19e-01
SARS-CoV-1 Infection 46 3.97e-01 -7.22e-02 5.86e-01
Signaling by Leptin 10 6.93e-01 7.21e-02 8.41e-01
FOXO-mediated transcription of cell death genes 14 6.41e-01 -7.20e-02 8.04e-01
E3 ubiquitin ligases ubiquitinate target proteins 41 4.26e-01 7.19e-02 6.13e-01
DARPP-32 events 21 5.68e-01 -7.19e-02 7.39e-01
Nucleotide catabolism 21 5.69e-01 -7.17e-02 7.40e-01
GPER1 signaling 25 5.35e-01 7.17e-02 7.14e-01
Antigen processing: Ubiquitination & Proteasome degradation 241 5.64e-02 -7.16e-02 1.56e-01
Transcriptional Regulation by VENTX 30 4.98e-01 -7.15e-02 6.78e-01
Interconversion of nucleotide di- and triphosphates 25 5.37e-01 -7.13e-02 7.15e-01
FCGR3A-mediated IL10 synthesis 22 5.65e-01 7.09e-02 7.38e-01
Stimuli-sensing channels 39 4.44e-01 -7.09e-02 6.29e-01
Termination of O-glycan biosynthesis 10 6.98e-01 -7.08e-02 8.44e-01
Signal Transduction 1356 2.11e-05 -7.07e-02 5.90e-04
Signaling by NTRK2 (TRKB) 15 6.40e-01 -6.97e-02 8.04e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 41 4.41e-01 -6.96e-02 6.26e-01
Neutrophil degranulation 307 3.84e-02 -6.91e-02 1.16e-01
Carboxyterminal post-translational modifications of tubulin 24 5.60e-01 6.88e-02 7.35e-01
Energy dependent regulation of mTOR by LKB1-AMPK 25 5.53e-01 -6.86e-02 7.28e-01
RHOC GTPase cycle 49 4.07e-01 -6.85e-02 5.96e-01
Activation of BAD and translocation to mitochondria 14 6.59e-01 6.82e-02 8.17e-01
RND2 GTPase cycle 34 4.97e-01 -6.74e-02 6.78e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 14 6.63e-01 6.73e-02 8.19e-01
Ca-dependent events 21 5.94e-01 -6.72e-02 7.64e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 20 6.05e-01 6.68e-02 7.74e-01
RAB GEFs exchange GTP for GDP on RABs 64 3.56e-01 6.68e-02 5.52e-01
Toll-like Receptor Cascades 108 2.32e-01 -6.67e-02 4.18e-01
Platelet activation, signaling and aggregation 132 1.94e-01 -6.56e-02 3.70e-01
CD209 (DC-SIGN) signaling 15 6.60e-01 6.56e-02 8.18e-01
FGFR1 mutant receptor activation 20 6.15e-01 -6.49e-02 7.84e-01
Removal of the Flap Intermediate from the C-strand 15 6.65e-01 -6.46e-02 8.19e-01
Activation of BH3-only proteins 27 5.62e-01 -6.45e-02 7.36e-01
Molecules associated with elastic fibres 12 6.99e-01 6.44e-02 8.44e-01
Opioid Signalling 58 4.00e-01 -6.39e-02 5.88e-01
Signalling to ERKs 25 5.83e-01 -6.35e-02 7.53e-01
Activation of GABAB receptors 18 6.46e-01 6.25e-02 8.04e-01
GABA B receptor activation 18 6.46e-01 6.25e-02 8.04e-01
Transcriptional regulation of granulopoiesis 25 5.89e-01 6.25e-02 7.59e-01
Cell surface interactions at the vascular wall 56 4.25e-01 6.17e-02 6.13e-01
Meiotic recombination 19 6.41e-01 -6.17e-02 8.04e-01
Listeria monocytogenes entry into host cells 14 6.90e-01 -6.15e-02 8.38e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 15 6.83e-01 6.09e-02 8.31e-01
Signaling by Erythropoietin 19 6.48e-01 6.04e-02 8.06e-01
Leishmania infection 112 2.72e-01 -6.02e-02 4.69e-01
RHO GTPase cycle 294 7.74e-02 -6.02e-02 1.95e-01
Caspase-mediated cleavage of cytoskeletal proteins 10 7.42e-01 -6.00e-02 8.71e-01
Visual phototransduction 34 5.48e-01 -5.96e-02 7.24e-01
Semaphorin interactions 39 5.24e-01 5.89e-02 7.03e-01
Signaling by WNT in cancer 23 6.29e-01 -5.82e-02 7.97e-01
trans-Golgi Network Vesicle Budding 51 4.75e-01 -5.79e-02 6.59e-01
G beta:gamma signalling through PI3Kgamma 17 6.80e-01 5.77e-02 8.29e-01
Prolonged ERK activation events 13 7.20e-01 5.74e-02 8.61e-01
Signaling by high-kinase activity BRAF mutants 22 6.44e-01 5.68e-02 8.04e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 7.56e-01 5.67e-02 8.74e-01
alpha-linolenic acid (ALA) metabolism 10 7.56e-01 5.67e-02 8.74e-01
RHOBTB2 GTPase cycle 20 6.62e-01 -5.64e-02 8.19e-01
Signaling by Hippo 12 7.36e-01 5.63e-02 8.69e-01
Elevation of cytosolic Ca2+ levels 10 7.59e-01 -5.61e-02 8.75e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 23 6.43e-01 -5.58e-02 8.04e-01
NOD1/2 Signaling Pathway 23 6.46e-01 -5.53e-02 8.04e-01
SUMOylation of DNA methylation proteins 14 7.21e-01 5.51e-02 8.61e-01
Golgi Associated Vesicle Biogenesis 38 5.57e-01 -5.51e-02 7.33e-01
MAPK family signaling cascades 191 1.99e-01 -5.41e-02 3.70e-01
Non-integrin membrane-ECM interactions 14 7.29e-01 -5.34e-02 8.65e-01
Glutamate Neurotransmitter Release Cycle 12 7.49e-01 5.32e-02 8.72e-01
Phase I - Functionalization of compounds 30 6.14e-01 5.32e-02 7.84e-01
Downstream signal transduction 20 6.81e-01 5.31e-02 8.29e-01
Neurexins and neuroligins 21 6.74e-01 -5.30e-02 8.26e-01
Unfolded Protein Response (UPR) 76 4.27e-01 -5.27e-02 6.13e-01
Signaling by NTRK1 (TRKA) 79 4.19e-01 -5.27e-02 6.08e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 10 7.73e-01 -5.26e-02 8.81e-01
Generation of second messenger molecules 15 7.25e-01 5.24e-02 8.64e-01
Processing of Capped Intronless Pre-mRNA 23 6.65e-01 -5.21e-02 8.19e-01
Nuclear events stimulated by ALK signaling in cancer 14 7.37e-01 5.18e-02 8.69e-01
FOXO-mediated transcription of cell cycle genes 13 7.47e-01 -5.16e-02 8.72e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 16 7.21e-01 5.16e-02 8.61e-01
Late endosomal microautophagy 23 6.70e-01 -5.14e-02 8.22e-01
RHOD GTPase cycle 36 5.95e-01 5.13e-02 7.64e-01
RAC1 GTPase cycle 110 3.55e-01 -5.11e-02 5.52e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 29 6.37e-01 5.06e-02 8.04e-01
Nuclear signaling by ERBB4 16 7.27e-01 -5.04e-02 8.64e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 7.45e-01 -5.03e-02 8.72e-01
Anti-inflammatory response favouring Leishmania parasite infection 54 5.24e-01 5.01e-02 7.03e-01
Leishmania parasite growth and survival 54 5.24e-01 5.01e-02 7.03e-01
Cytosolic sulfonation of small molecules 10 7.84e-01 5.01e-02 8.89e-01
RHOU GTPase cycle 32 6.25e-01 4.99e-02 7.93e-01
Processing of Intronless Pre-mRNAs 15 7.40e-01 -4.95e-02 8.70e-01
Assembly Of The HIV Virion 14 7.49e-01 -4.94e-02 8.72e-01
ER Quality Control Compartment (ERQC) 18 7.19e-01 4.90e-02 8.61e-01
MAPK1/MAPK3 signaling 164 2.83e-01 -4.88e-02 4.81e-01
Lysosome Vesicle Biogenesis 24 6.80e-01 -4.86e-02 8.29e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 14 7.54e-01 -4.83e-02 8.74e-01
Triglyceride catabolism 11 7.86e-01 -4.72e-02 8.91e-01
Assembly and cell surface presentation of NMDA receptors 13 7.69e-01 4.70e-02 8.79e-01
GABA receptor activation 19 7.23e-01 4.70e-02 8.62e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 26 6.79e-01 -4.69e-02 8.29e-01
Protein localization 123 3.72e-01 -4.67e-02 5.67e-01
Inflammasomes 16 7.46e-01 -4.67e-02 8.72e-01
Purine ribonucleoside monophosphate biosynthesis 10 7.98e-01 -4.67e-02 9.00e-01
CaM pathway 20 7.19e-01 -4.65e-02 8.61e-01
Calmodulin induced events 20 7.19e-01 -4.65e-02 8.61e-01
Regulation of signaling by CBL 14 7.63e-01 4.65e-02 8.76e-01
Metabolism of porphyrins 15 7.61e-01 4.53e-02 8.75e-01
Transport of small molecules 359 1.43e-01 -4.53e-02 3.00e-01
Effects of PIP2 hydrolysis 19 7.35e-01 -4.48e-02 8.69e-01
E2F mediated regulation of DNA replication 19 7.37e-01 4.45e-02 8.69e-01
Regulation of RUNX1 Expression and Activity 17 7.51e-01 -4.44e-02 8.72e-01
Citric acid cycle (TCA cycle) 19 7.38e-01 4.44e-02 8.69e-01
A tetrasaccharide linker sequence is required for GAG synthesis 10 8.09e-01 4.42e-02 9.06e-01
Gluconeogenesis 24 7.11e-01 -4.37e-02 8.55e-01
RAC3 GTPase cycle 59 5.62e-01 -4.37e-02 7.36e-01
RHOB GTPase cycle 44 6.17e-01 -4.36e-02 7.85e-01
Meiotic synapsis 25 7.08e-01 4.32e-02 8.53e-01
The phototransduction cascade 18 7.51e-01 4.32e-02 8.72e-01
Metabolism of cofactors 17 7.59e-01 -4.30e-02 8.75e-01
Activation of kainate receptors upon glutamate binding 17 7.59e-01 4.30e-02 8.75e-01
Collagen formation 28 6.94e-01 4.29e-02 8.41e-01
Neuronal System 139 3.87e-01 4.26e-02 5.77e-01
RAF/MAP kinase cascade 159 3.56e-01 -4.25e-02 5.52e-01
Attenuation phase 19 7.49e-01 -4.23e-02 8.72e-01
Hemostasis 304 2.09e-01 -4.21e-02 3.84e-01
Integrin cell surface interactions 25 7.16e-01 4.20e-02 8.61e-01
Costimulation by the CD28 family 44 6.30e-01 -4.20e-02 7.97e-01
IRS-related events triggered by IGF1R 22 7.34e-01 4.19e-02 8.69e-01
Synthesis of PIPs at the plasma membrane 36 6.66e-01 -4.16e-02 8.19e-01
DAP12 signaling 19 7.57e-01 -4.11e-02 8.74e-01
Cardiac conduction 43 6.45e-01 4.06e-02 8.04e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 16 7.80e-01 -4.04e-02 8.85e-01
ECM proteoglycans 13 8.01e-01 -4.04e-02 9.01e-01
Downstream signaling of activated FGFR1 12 8.09e-01 4.02e-02 9.06e-01
Downstream signaling of activated FGFR2 12 8.09e-01 4.02e-02 9.06e-01
Downstream signaling of activated FGFR3 12 8.09e-01 4.02e-02 9.06e-01
Downstream signaling of activated FGFR4 12 8.09e-01 4.02e-02 9.06e-01
Biological oxidations 79 5.37e-01 -4.02e-02 7.15e-01
Muscle contraction 67 5.70e-01 -4.02e-02 7.40e-01
Pre-NOTCH Expression and Processing 46 6.39e-01 -4.00e-02 8.04e-01
Calnexin/calreticulin cycle 23 7.42e-01 3.97e-02 8.71e-01
Sialic acid metabolism 23 7.42e-01 -3.97e-02 8.71e-01
Transmission across Chemical Synapses 101 4.96e-01 3.92e-02 6.78e-01
Peroxisomal protein import 48 6.39e-01 -3.91e-02 8.04e-01
Metabolism of steroids 86 5.37e-01 -3.86e-02 7.15e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 29 7.20e-01 3.84e-02 8.61e-01
CDC42 GTPase cycle 97 5.14e-01 3.84e-02 6.92e-01
Signaling by NODAL 12 8.18e-01 3.83e-02 9.13e-01
MTOR signalling 36 6.96e-01 -3.76e-02 8.43e-01
EGFR downregulation 20 7.71e-01 -3.76e-02 8.80e-01
Fatty acid metabolism 104 5.11e-01 3.74e-02 6.90e-01
Sema3A PAK dependent Axon repulsion 11 8.30e-01 3.73e-02 9.19e-01
Netrin-1 signaling 25 7.50e-01 3.68e-02 8.72e-01
Interleukin receptor SHC signaling 15 8.06e-01 -3.67e-02 9.06e-01
Cell-Cell communication 48 6.61e-01 3.66e-02 8.19e-01
Interleukin-20 family signaling 13 8.20e-01 3.65e-02 9.14e-01
FOXO-mediated transcription 46 6.76e-01 -3.56e-02 8.27e-01
Signaling by Activin 12 8.32e-01 -3.54e-02 9.19e-01
Diseases of carbohydrate metabolism 23 7.69e-01 3.54e-02 8.79e-01
Role of LAT2/NTAL/LAB on calcium mobilization 10 8.46e-01 3.54e-02 9.27e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 50 6.67e-01 3.51e-02 8.20e-01
Cyclin A/B1/B2 associated events during G2/M transition 22 7.76e-01 -3.51e-02 8.82e-01
Transport of bile salts and organic acids, metal ions and amine compounds 34 7.26e-01 -3.47e-02 8.64e-01
Signaling by FGFR4 25 7.64e-01 -3.46e-02 8.76e-01
O-linked glycosylation of mucins 26 7.60e-01 3.45e-02 8.75e-01
IRE1alpha activates chaperones 43 6.98e-01 3.42e-02 8.44e-01
SLC-mediated transmembrane transport 105 5.50e-01 3.38e-02 7.26e-01
Regulation of IFNA/IFNB signaling 12 8.40e-01 3.36e-02 9.25e-01
Protein-protein interactions at synapses 33 7.39e-01 -3.35e-02 8.70e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 21 7.91e-01 3.34e-02 8.95e-01
Sema4D in semaphorin signaling 15 8.24e-01 -3.33e-02 9.14e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 7.68e-01 -3.28e-02 8.79e-01
PKA activation 10 8.59e-01 3.25e-02 9.33e-01
Rab regulation of trafficking 94 5.88e-01 -3.24e-02 7.59e-01
MAPK targets/ Nuclear events mediated by MAP kinases 23 7.90e-01 -3.21e-02 8.94e-01
Telomere C-strand synthesis initiation 10 8.62e-01 -3.18e-02 9.33e-01
Synthesis of glycosylphosphatidylinositol (GPI) 14 8.37e-01 3.17e-02 9.23e-01
Interleukin-2 family signaling 28 7.73e-01 3.15e-02 8.81e-01
RET signaling 23 7.94e-01 3.15e-02 8.97e-01
Depolymerisation of the Nuclear Lamina 13 8.44e-01 3.15e-02 9.26e-01
Pyroptosis 18 8.21e-01 -3.07e-02 9.14e-01
ADORA2B mediated anti-inflammatory cytokines production 33 7.60e-01 3.07e-02 8.75e-01
Signaling by NTRKs 87 6.23e-01 -3.05e-02 7.92e-01
Signaling by CSF3 (G-CSF) 24 7.97e-01 -3.04e-02 8.99e-01
ADP signalling through P2Y purinoceptor 12 13 8.51e-01 3.01e-02 9.31e-01
DCC mediated attractive signaling 11 8.63e-01 3.01e-02 9.33e-01
Sensory Perception 68 6.71e-01 -2.98e-02 8.23e-01
The NLRP3 inflammasome 12 8.61e-01 -2.93e-02 9.33e-01
Signaling by BRAF and RAF1 fusions 42 7.46e-01 2.89e-02 8.72e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 8.25e-01 2.86e-02 9.14e-01
Neurodegenerative Diseases 20 8.25e-01 2.86e-02 9.14e-01
Mitochondrial protein import 48 7.33e-01 -2.85e-02 8.69e-01
Interleukin-6 family signaling 13 8.59e-01 2.85e-02 9.33e-01
Meiosis 42 7.52e-01 -2.82e-02 8.72e-01
G beta:gamma signalling through CDC42 13 8.62e-01 2.78e-02 9.33e-01
Growth hormone receptor signaling 17 8.42e-01 2.78e-02 9.26e-01
Signaling by FGFR1 28 8.01e-01 -2.76e-02 9.01e-01
Potential therapeutics for SARS 66 7.02e-01 -2.72e-02 8.47e-01
Phospholipid metabolism 133 5.89e-01 -2.72e-02 7.59e-01
PKA-mediated phosphorylation of CREB 11 8.78e-01 2.67e-02 9.38e-01
Protein methylation 14 8.66e-01 2.61e-02 9.33e-01
G beta:gamma signalling through PLC beta 13 8.71e-01 2.61e-02 9.33e-01
Presynaptic function of Kainate receptors 13 8.71e-01 2.61e-02 9.33e-01
Signaling by FGFR3 26 8.23e-01 -2.54e-02 9.14e-01
Inositol phosphate metabolism 30 8.11e-01 2.52e-02 9.07e-01
Metabolism of lipids 439 3.91e-01 -2.41e-02 5.81e-01
Branched-chain amino acid catabolism 20 8.53e-01 -2.39e-02 9.32e-01
Heme biosynthesis 10 8.96e-01 2.38e-02 9.47e-01
Signaling by KIT in disease 16 8.71e-01 -2.35e-02 9.33e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 16 8.71e-01 -2.35e-02 9.33e-01
Interleukin-6 signaling 10 8.98e-01 2.33e-02 9.47e-01
MAP kinase activation 49 7.78e-01 -2.33e-02 8.84e-01
Budding and maturation of HIV virion 24 8.44e-01 -2.32e-02 9.26e-01
Signaling by RAF1 mutants 25 8.41e-01 2.32e-02 9.25e-01
Negative regulation of the PI3K/AKT network 56 7.65e-01 2.32e-02 8.76e-01
Signaling by SCF-KIT 32 8.21e-01 2.31e-02 9.14e-01
Neurotransmitter receptors and postsynaptic signal transmission 77 7.28e-01 2.30e-02 8.64e-01
Negative regulation of MAPK pathway 36 8.14e-01 2.27e-02 9.09e-01
Peroxisomal lipid metabolism 22 8.55e-01 -2.25e-02 9.33e-01
Post-translational modification: synthesis of GPI-anchored proteins 31 8.32e-01 2.20e-02 9.19e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 8.87e-01 2.18e-02 9.42e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 8.97e-01 -2.16e-02 9.47e-01
Protein ubiquitination 59 7.76e-01 2.15e-02 8.82e-01
Cholesterol biosynthesis 22 8.63e-01 -2.13e-02 9.33e-01
Formation of the beta-catenin:TCF transactivating complex 25 8.60e-01 -2.03e-02 9.33e-01
Processing of SMDT1 13 9.00e-01 -2.01e-02 9.47e-01
Mitochondrial calcium ion transport 19 8.82e-01 -1.97e-02 9.40e-01
Frs2-mediated activation 11 9.11e-01 1.96e-02 9.51e-01
FCERI mediated MAPK activation 23 8.72e-01 -1.95e-02 9.33e-01
RNA Polymerase II Transcription Termination 45 8.22e-01 -1.93e-02 9.14e-01
IGF1R signaling cascade 23 8.73e-01 1.93e-02 9.33e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 23 8.73e-01 1.93e-02 9.33e-01
Signaling by FGFR1 in disease 24 8.72e-01 -1.89e-02 9.33e-01
EPH-ephrin mediated repulsion of cells 25 8.70e-01 -1.89e-02 9.33e-01
Regulation of insulin secretion 40 8.39e-01 1.85e-02 9.25e-01
Long-term potentiation 11 9.15e-01 1.85e-02 9.53e-01
Negative regulation of MET activity 16 9.01e-01 1.80e-02 9.47e-01
RHOJ GTPase cycle 37 8.51e-01 -1.79e-02 9.31e-01
RAS processing 15 9.06e-01 1.76e-02 9.48e-01
N-glycan antennae elongation in the medial/trans-Golgi 17 9.02e-01 1.73e-02 9.47e-01
Interleukin-10 signaling 13 9.14e-01 1.73e-02 9.53e-01
Platelet homeostasis 49 8.36e-01 1.71e-02 9.23e-01
GPVI-mediated activation cascade 23 8.88e-01 -1.69e-02 9.42e-01
Transport of vitamins, nucleosides, and related molecules 21 8.94e-01 1.68e-02 9.46e-01
Regulation of MECP2 expression and activity 23 8.91e-01 -1.66e-02 9.44e-01
RHOF GTPase cycle 25 8.88e-01 1.63e-02 9.42e-01
PINK1-PRKN Mediated Mitophagy 20 9.01e-01 1.60e-02 9.47e-01
Metabolism of steroid hormones 13 9.21e-01 1.60e-02 9.56e-01
Nucleotide biosynthesis 12 9.26e-01 -1.55e-02 9.60e-01
Chondroitin sulfate/dermatan sulfate metabolism 27 8.91e-01 -1.52e-02 9.44e-01
Interleukin-15 signaling 11 9.31e-01 1.50e-02 9.61e-01
Vitamin B5 (pantothenate) metabolism 11 9.32e-01 -1.48e-02 9.61e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 27 8.94e-01 1.48e-02 9.46e-01
Ephrin signaling 12 9.30e-01 1.46e-02 9.61e-01
Interferon alpha/beta signaling 51 8.60e-01 -1.43e-02 9.33e-01
Post NMDA receptor activation events 38 8.79e-01 -1.43e-02 9.38e-01
Interleukin-17 signaling 52 8.64e-01 1.38e-02 9.33e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 9.32e-01 1.37e-02 9.61e-01
Mitochondrial Fatty Acid Beta-Oxidation 26 9.06e-01 1.34e-02 9.48e-01
XBP1(S) activates chaperone genes 42 8.84e-01 1.31e-02 9.40e-01
Neurotransmitter release cycle 20 9.20e-01 -1.29e-02 9.56e-01
PKMTs methylate histone lysines 31 9.04e-01 -1.25e-02 9.48e-01
RHOG GTPase cycle 49 8.81e-01 1.23e-02 9.40e-01
Glycerophospholipid biosynthesis 74 8.56e-01 1.22e-02 9.33e-01
Glycosaminoglycan metabolism 64 8.67e-01 -1.21e-02 9.33e-01
Sphingolipid metabolism 49 8.84e-01 -1.21e-02 9.40e-01
mRNA 3’-end processing 37 9.06e-01 -1.12e-02 9.48e-01
Signaling by Insulin receptor 42 9.01e-01 -1.11e-02 9.47e-01
Sensory processing of sound 27 9.24e-01 1.06e-02 9.58e-01
Sensory processing of sound by inner hair cells of the cochlea 27 9.24e-01 1.06e-02 9.58e-01
RHOA GTPase cycle 93 8.60e-01 1.06e-02 9.33e-01
RHOQ GTPase cycle 39 9.09e-01 1.06e-02 9.50e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 14 9.46e-01 1.05e-02 9.71e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 24 9.30e-01 1.04e-02 9.61e-01
Defective Intrinsic Pathway for Apoptosis 23 9.31e-01 -1.04e-02 9.61e-01
Heparan sulfate/heparin (HS-GAG) metabolism 22 9.41e-01 9.16e-03 9.68e-01
PI3K/AKT Signaling in Cancer 52 9.14e-01 8.65e-03 9.53e-01
Regulation of FZD by ubiquitination 12 9.59e-01 -8.56e-03 9.76e-01
Reproduction 48 9.20e-01 8.33e-03 9.56e-01
Pre-NOTCH Processing in Golgi 16 9.56e-01 7.98e-03 9.74e-01
Telomere Extension By Telomerase 20 9.52e-01 -7.83e-03 9.71e-01
Miscellaneous transport and binding events 14 9.60e-01 7.75e-03 9.76e-01
The role of Nef in HIV-1 replication and disease pathogenesis 19 9.55e-01 7.54e-03 9.73e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 29 9.49e-01 6.85e-03 9.71e-01
Signaling by RAS mutants 29 9.49e-01 6.85e-03 9.71e-01
Signaling by moderate kinase activity BRAF mutants 29 9.49e-01 6.85e-03 9.71e-01
Signaling downstream of RAS mutants 29 9.49e-01 6.85e-03 9.71e-01
Fatty acyl-CoA biosynthesis 26 9.52e-01 -6.84e-03 9.71e-01
ERK/MAPK targets 16 9.63e-01 -6.76e-03 9.77e-01
Peptide hormone metabolism 31 9.49e-01 -6.62e-03 9.71e-01
COPII-mediated vesicle transport 51 9.36e-01 6.47e-03 9.64e-01
Activation of NMDA receptors and postsynaptic events 44 9.41e-01 -6.45e-03 9.68e-01
Hyaluronan metabolism 11 9.71e-01 -6.39e-03 9.85e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 9.50e-01 6.36e-03 9.71e-01
Hyaluronan uptake and degradation 10 9.76e-01 5.42e-03 9.89e-01
Platelet sensitization by LDL 13 9.75e-01 -5.02e-03 9.88e-01
L1CAM interactions 41 9.62e-01 -4.30e-03 9.77e-01
Ras activation upon Ca2+ influx through NMDA receptor 10 9.82e-01 -4.23e-03 9.91e-01
Gastrin-CREB signalling pathway via PKC and MAPK 11 9.84e-01 -3.40e-03 9.94e-01
Inactivation of CSF3 (G-CSF) signaling 19 9.81e-01 3.22e-03 9.91e-01
HSF1 activation 21 9.85e-01 2.32e-03 9.94e-01
Interferon gamma signaling 55 9.78e-01 2.18e-03 9.89e-01
HDACs deacetylate histones 28 9.86e-01 -1.87e-03 9.94e-01
Negative regulation of FGFR1 signaling 18 9.90e-01 1.73e-03 9.94e-01
Negative regulation of FGFR2 signaling 18 9.90e-01 1.73e-03 9.94e-01
Negative regulation of FGFR3 signaling 18 9.90e-01 1.73e-03 9.94e-01
Negative regulation of FGFR4 signaling 18 9.90e-01 1.73e-03 9.94e-01
Inactivation, recovery and regulation of the phototransduction cascade 17 9.92e-01 -1.46e-03 9.95e-01
Sema4D induced cell migration and growth-cone collapse 12 9.95e-01 1.10e-03 9.97e-01
Metabolic disorders of biological oxidation enzymes 14 9.98e-01 -3.63e-04 9.99e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 12 9.99e-01 -1.67e-04 9.99e-01
Integration of energy metabolism 60 9.99e-01 -7.39e-05 9.99e-01


Detailed Gene set reports



NRIF signals cell death from the nucleus

NRIF signals cell death from the nucleus
607
set NRIF signals cell death from the nucleus
setSize 14
pANOVA 0.000175
s.dist -0.579
p.adjustANOVA 0.00204



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
ITGB3BP -10480.0
SQSTM1 -10290.5
PSENEN -9992.0
NCSTN -9956.0
UBC -9774.5
TRAF6 -9749.5
PSEN2 -8618.5
UBB -7535.5
APH1A -7419.5
PSEN1 -7369.5
APH1B -6679.5
MAPK8 -6098.5
UBA52 -1275.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
ITGB3BP -10480.0
SQSTM1 -10290.5
PSENEN -9992.0
NCSTN -9956.0
UBC -9774.5
TRAF6 -9749.5
PSEN2 -8618.5
UBB -7535.5
APH1A -7419.5
PSEN1 -7369.5
APH1B -6679.5
MAPK8 -6098.5
UBA52 -1275.5


SARS-CoV-2 modulates autophagy

SARS-CoV-2 modulates autophagy
900
set SARS-CoV-2 modulates autophagy
setSize 11
pANOVA 0.00181
s.dist -0.543
p.adjustANOVA 0.0124



Top enriched genes

Top 20 genes
GeneID Gene Rank
UVRAG -10468.5
VPS45 -10027.5
VPS16 -9898.5
VPS11 -9683.5
VPS18 -8349.5
VPS33A -8313.5
MAP1LC3B -7712.5
VPS33B -7043.5
TUFM -6595.5
VPS39 -6066.5
VPS41 -4606.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UVRAG -10468.5
VPS45 -10027.5
VPS16 -9898.5
VPS11 -9683.5
VPS18 -8349.5
VPS33A -8313.5
MAP1LC3B -7712.5
VPS33B -7043.5
TUFM -6595.5
VPS39 -6066.5
VPS41 -4606.5


p75NTR signals via NF-kB

p75NTR signals via NF-kB
1193
set p75NTR signals via NF-kB
setSize 11
pANOVA 0.00267
s.dist -0.523
p.adjustANOVA 0.0158



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
NFKBIA -10432.5
SQSTM1 -10290.5
UBC -9774.5
TRAF6 -9749.5
MYD88 -8779.5
PRKCI -7966.5
UBB -7535.5
RELA -7257.5
IKBKB -3625.5
UBA52 -1275.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
NFKBIA -10432.5
SQSTM1 -10290.5
UBC -9774.5
TRAF6 -9749.5
MYD88 -8779.5
PRKCI -7966.5
UBB -7535.5
RELA -7257.5
IKBKB -3625.5
UBA52 -1275.5


Competing endogenous RNAs (ceRNAs) regulate PTEN translation

Competing endogenous RNAs (ceRNAs) regulate PTEN translation
162
set Competing endogenous RNAs (ceRNAs) regulate PTEN translation
setSize 10
pANOVA 0.0156
s.dist 0.441
p.adjustANOVA 0.0588



Top enriched genes

Top 20 genes
GeneID Gene Rank
MIR19A 0.5
AGO3 0.5
AGO1 0.5
VAPA -774.5
TNRC6B -1405.5
MOV10 -2872.5
CNOT6L -3615.5
TNRC6A -3972.5
AGO2 -4372.5
MIR17 -4608.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MIR19A 0.5
AGO3 0.5
AGO1 0.5
VAPA -774.5
TNRC6B -1405.5
MOV10 -2872.5
CNOT6L -3615.5
TNRC6A -3972.5
AGO2 -4372.5
MIR17 -4608.5


Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes
164
set Condensation of Prometaphase Chromosomes
setSize 10
pANOVA 0.0175
s.dist -0.434
p.adjustANOVA 0.0636



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSNK2B -10802.5
CCNB2 -9645.5
CDK1 -9228.5
NCAPH -8938.5
NCAPD2 -8680.5
SMC4 -8380.5
SMC2 -8202.5
CSNK2A2 -5375.5
NCAPG -4888.0
CCNB1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSNK2B -10802.5
CCNB2 -9645.5
CDK1 -9228.5
NCAPH -8938.5
NCAPD2 -8680.5
SMC4 -8380.5
SMC2 -8202.5
CSNK2A2 -5375.5
NCAPG -4888.0
CCNB1 0.5


Translesion Synthesis by POLH

Translesion Synthesis by POLH
1129
set Translesion Synthesis by POLH
setSize 17
pANOVA 0.00271
s.dist -0.42
p.adjustANOVA 0.0158



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
RFC4 -10482.5
NPLOC4 -10227.5
POLH -10159.0
UBC -9774.5
RFC5 -9633.5
RCHY1 -9238.0
RFC2 -8792.5
PCNA -7767.5
UBB -7535.5
SPRTN -6836.5
UFD1L -6771.5
RPA3 -5701.5
RPA1 -5561.0
VCP -4953.5
UBA52 -1275.5
RFC3 851.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
RFC4 -10482.5
NPLOC4 -10227.5
POLH -10159.0
UBC -9774.5
RFC5 -9633.5
RCHY1 -9238.0
RFC2 -8792.5
PCNA -7767.5
UBB -7535.5
SPRTN -6836.5
UFD1L -6771.5
RPA3 -5701.5
RPA1 -5561.0
VCP -4953.5
UBA52 -1275.5
RFC3 851.5


NOTCH2 Activation and Transmission of Signal to the Nucleus

NOTCH2 Activation and Transmission of Signal to the Nucleus
600
set NOTCH2 Activation and Transmission of Signal to the Nucleus
setSize 12
pANOVA 0.0131
s.dist -0.413
p.adjustANOVA 0.0514



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
PSENEN -9992.0
NCSTN -9956.0
UBC -9774.5
PSEN2 -8618.5
ADAM10 -8132.5
UBB -7535.5
APH1A -7419.5
PSEN1 -7369.5
APH1B -6679.5
UBA52 -1275.5
MIB1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
PSENEN -9992.0
NCSTN -9956.0
UBC -9774.5
PSEN2 -8618.5
ADAM10 -8132.5
UBB -7535.5
APH1A -7419.5
PSEN1 -7369.5
APH1B -6679.5
UBA52 -1275.5
MIB1 0.5


Diseases associated with N-glycosylation of proteins

Diseases associated with N-glycosylation of proteins
234
set Diseases associated with N-glycosylation of proteins
setSize 18
pANOVA 0.00277
s.dist -0.407
p.adjustANOVA 0.016



Top enriched genes

Top 20 genes
GeneID Gene Rank
DPAGT1 -10676.5
GLB1 -10591.0
MGAT2 -10332.0
ALG3 -10272.5
NEU1 -10269.5
RFT1 -10261.5
ALG9 -9457.5
MOGS -9052.5
ALG11 -8584.0
ALG8 -8410.5
ALG2 -7244.0
ALG12 -5269.5
MAN1B1 -4475.5
ALG14 -3989.5
B4GALT1 -3309.5
CTSA -3264.5
ALG6 -3106.5
MPDU1 -2002.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DPAGT1 -10676.5
GLB1 -10591.0
MGAT2 -10332.0
ALG3 -10272.5
NEU1 -10269.5
RFT1 -10261.5
ALG9 -9457.5
MOGS -9052.5
ALG11 -8584.0
ALG8 -8410.5
ALG2 -7244.0
ALG12 -5269.5
MAN1B1 -4475.5
ALG14 -3989.5
B4GALT1 -3309.5
CTSA -3264.5
ALG6 -3106.5
MPDU1 -2002.5


TNFR1-induced proapoptotic signaling

TNFR1-induced proapoptotic signaling
1064
set TNFR1-induced proapoptotic signaling
setSize 12
pANOVA 0.0145
s.dist -0.407
p.adjustANOVA 0.0559



Top enriched genes

Top 20 genes
GeneID Gene Rank
CASP8 -10707.5
CYLD -10542.5
USP4 -10374.5
USP2 -9709.5
TNFRSF1A -8717.5
TNFAIP3 -8598.5
OTUD7B -7430.5
FADD -6271.5
TRADD -5980.0
TRAF2 -5002.5
USP21 -4564.5
TNF 843.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP8 -10707.5
CYLD -10542.5
USP4 -10374.5
USP2 -9709.5
TNFRSF1A -8717.5
TNFAIP3 -8598.5
OTUD7B -7430.5
FADD -6271.5
TRADD -5980.0
TRAF2 -5002.5
USP21 -4564.5
TNF 843.5


Methylation

Methylation
558
set Methylation
setSize 10
pANOVA 0.0283
s.dist -0.4
p.adjustANOVA 0.0904



Top enriched genes

Top 20 genes
GeneID Gene Rank
TRMT112 -10560.0
MTR -9799.5
MAT2A -9548.5
AHCY -9247.5
GSTO1 -8800.5
MAT2B -8739.5
TPMT -7305.0
COMT -3509.5
N6AMT1 -3440.5
MTRR -1180.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRMT112 -10560.0
MTR -9799.5
MAT2A -9548.5
AHCY -9247.5
GSTO1 -8800.5
MAT2B -8739.5
TPMT -7305.0
COMT -3509.5
N6AMT1 -3440.5
MTRR -1180.5


NOTCH3 Activation and Transmission of Signal to the Nucleus

NOTCH3 Activation and Transmission of Signal to the Nucleus
601
set NOTCH3 Activation and Transmission of Signal to the Nucleus
setSize 15
pANOVA 0.00772
s.dist -0.397
p.adjustANOVA 0.0354



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
PSENEN -9992.0
NCSTN -9956.0
UBC -9774.5
PSEN2 -8618.5
ADAM10 -8132.5
UBB -7535.5
WWP2 -7498.5
APH1A -7419.5
PSEN1 -7369.5
APH1B -6679.5
YBX1 -6504.5
TACC3 -6398.5
UBA52 -1275.5
MIB1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
PSENEN -9992.0
NCSTN -9956.0
UBC -9774.5
PSEN2 -8618.5
ADAM10 -8132.5
UBB -7535.5
WWP2 -7498.5
APH1A -7419.5
PSEN1 -7369.5
APH1B -6679.5
YBX1 -6504.5
TACC3 -6398.5
UBA52 -1275.5
MIB1 0.5


Signaling by FGFR2 IIIa TM

Signaling by FGFR2 IIIa TM
971
set Signaling by FGFR2 IIIa TM
setSize 15
pANOVA 0.00905
s.dist -0.389
p.adjustANOVA 0.0405



Top enriched genes

Top 20 genes
GeneID Gene Rank
GTF2F2 -10444.5
POLR2A -10396.5
POLR2B -10064.5
NCBP2 -9490.5
POLR2E -9455.5
NCBP1 -8527.0
POLR2D -8055.5
POLR2F -7875.0
POLR2K -6878.5
POLR2I -6700.0
POLR2H -6204.5
POLR2L -4619.0
GTF2F1 -3875.5
POLR2C -3765.5
POLR2G -827.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GTF2F2 -10444.5
POLR2A -10396.5
POLR2B -10064.5
NCBP2 -9490.5
POLR2E -9455.5
NCBP1 -8527.0
POLR2D -8055.5
POLR2F -7875.0
POLR2K -6878.5
POLR2I -6700.0
POLR2H -6204.5
POLR2L -4619.0
GTF2F1 -3875.5
POLR2C -3765.5
POLR2G -827.5


Signaling by ERBB2 ECD mutants

Signaling by ERBB2 ECD mutants
960
set Signaling by ERBB2 ECD mutants
setSize 10
pANOVA 0.0405
s.dist -0.374
p.adjustANOVA 0.121



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDC37 -10184.0
HSP90AA1 -9625.5
PIK3CA -9239.5
PIK3R1 -8929.5
GRB2 -8360.5
SHC1 -7672.0
KRAS -7550.5
ERBB2 -4547.5
PLCG1 -2890.5
HRAS -1555.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC37 -10184.0
HSP90AA1 -9625.5
PIK3CA -9239.5
PIK3R1 -8929.5
GRB2 -8360.5
SHC1 -7672.0
KRAS -7550.5
ERBB2 -4547.5
PLCG1 -2890.5
HRAS -1555.5


Bile acid and bile salt metabolism

Bile acid and bile salt metabolism
84
set Bile acid and bile salt metabolism
setSize 15
pANOVA 0.0125
s.dist 0.373
p.adjustANOVA 0.0496



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC51A 895.5
SCP2 663.5
OSBPL3 660.5
OSBP 0.5
SLC27A2 -776.5
STARD5 -828.5
OSBPL7 -1381.5
SLC27A5 -1558.5
ACOT8 -1604.0
OSBPL2 -2834.5
HSD17B4 -4049.5
NCOA2 -4907.5
AMACR -5542.5
OSBPL9 -7249.5
CYP46A1 -10125.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC51A 895.5
SCP2 663.5
OSBPL3 660.5
OSBP 0.5
SLC27A2 -776.5
STARD5 -828.5
OSBPL7 -1381.5
SLC27A5 -1558.5
ACOT8 -1604.0
OSBPL2 -2834.5
HSD17B4 -4049.5
NCOA2 -4907.5
AMACR -5542.5
OSBPL9 -7249.5
CYP46A1 -10125.5


Signaling by NOTCH2

Signaling by NOTCH2
993
set Signaling by NOTCH2
setSize 18
pANOVA 0.00621
s.dist -0.372
p.adjustANOVA 0.0305



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
RBPJ -10186.5
PSENEN -9992.0
NCSTN -9956.0
UBC -9774.5
PSEN2 -8618.5
EP300 -8181.5
ADAM10 -8132.5
UBB -7535.5
APH1A -7419.5
PSEN1 -7369.5
APH1B -6679.5
MAML2 -6279.5
MAML3 -6182.5
CREB1 -5001.5
MAML1 -3474.5
UBA52 -1275.5
MIB1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
RBPJ -10186.5
PSENEN -9992.0
NCSTN -9956.0
UBC -9774.5
PSEN2 -8618.5
EP300 -8181.5
ADAM10 -8132.5
UBB -7535.5
APH1A -7419.5
PSEN1 -7369.5
APH1B -6679.5
MAML2 -6279.5
MAML3 -6182.5
CREB1 -5001.5
MAML1 -3474.5
UBA52 -1275.5
MIB1 0.5


Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
169
set Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
setSize 14
pANOVA 0.0172
s.dist -0.368
p.adjustANOVA 0.063



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
CDC37 -10184.0
UBC -9774.5
HSP90AA1 -9625.5
PIK3CA -9239.5
PIK3R1 -8929.5
GRB2 -8360.5
SHC1 -7672.0
KRAS -7550.5
UBB -7535.5
CBL -2893.5
PLCG1 -2890.5
HRAS -1555.5
UBA52 -1275.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
CDC37 -10184.0
UBC -9774.5
HSP90AA1 -9625.5
PIK3CA -9239.5
PIK3R1 -8929.5
GRB2 -8360.5
SHC1 -7672.0
KRAS -7550.5
UBB -7535.5
CBL -2893.5
PLCG1 -2890.5
HRAS -1555.5
UBA52 -1275.5


Signaling by Ligand-Responsive EGFR Variants in Cancer

Signaling by Ligand-Responsive EGFR Variants in Cancer
985
set Signaling by Ligand-Responsive EGFR Variants in Cancer
setSize 14
pANOVA 0.0172
s.dist -0.368
p.adjustANOVA 0.063



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
CDC37 -10184.0
UBC -9774.5
HSP90AA1 -9625.5
PIK3CA -9239.5
PIK3R1 -8929.5
GRB2 -8360.5
SHC1 -7672.0
KRAS -7550.5
UBB -7535.5
CBL -2893.5
PLCG1 -2890.5
HRAS -1555.5
UBA52 -1275.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
CDC37 -10184.0
UBC -9774.5
HSP90AA1 -9625.5
PIK3CA -9239.5
PIK3R1 -8929.5
GRB2 -8360.5
SHC1 -7672.0
KRAS -7550.5
UBB -7535.5
CBL -2893.5
PLCG1 -2890.5
HRAS -1555.5
UBA52 -1275.5


CLEC7A (Dectin-1) induces NFAT activation

CLEC7A (Dectin-1) induces NFAT activation
97
set CLEC7A (Dectin-1) induces NFAT activation
setSize 11
pANOVA 0.0358
s.dist -0.365
p.adjustANOVA 0.111



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITPR1 -10555.5
PPP3CB -9565.5
PPP3R1 -9006.5
ITPR2 -8776.5
PPP3CA -8771.5
ITPR3 -8555.5
NFATC3 -8384.5
CALM1 -8287.5
AHCYL1 -4168.5
NFATC2 -2112.5
NFATC1 1146.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITPR1 -10555.5
PPP3CB -9565.5
PPP3R1 -9006.5
ITPR2 -8776.5
PPP3CA -8771.5
ITPR3 -8555.5
NFATC3 -8384.5
CALM1 -8287.5
AHCYL1 -4168.5
NFATC2 -2112.5
NFATC1 1146.5


RORA activates gene expression

RORA activates gene expression
814
set RORA activates gene expression
setSize 11
pANOVA 0.0366
s.dist -0.364
p.adjustANOVA 0.113



Top enriched genes

Top 20 genes
GeneID Gene Rank
TGS1 -10568.0
TBL1XR1 -10562.5
EP300 -8181.5
CHD9 -8136.5
RORA -7781.5
MED1 -7744.5
CPT1A -7280.5
NCOA6 -6208.5
NCOA2 -4907.5
CREBBP -3132.5
SREBF1 -2431.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TGS1 -10568.0
TBL1XR1 -10562.5
EP300 -8181.5
CHD9 -8136.5
RORA -7781.5
MED1 -7744.5
CPT1A -7280.5
NCOA6 -6208.5
NCOA2 -4907.5
CREBBP -3132.5
SREBF1 -2431.5


Autodegradation of the E3 ubiquitin ligase COP1

Autodegradation of the E3 ubiquitin ligase COP1
72
set Autodegradation of the E3 ubiquitin ligase COP1
setSize 44
pANOVA 2.98e-05
s.dist -0.364
p.adjustANOVA 0.000716



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
TP53 -10761.0
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
TP53 -10761.0
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
ATM -8036.0
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
RFWD2 -2424.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


RNA Polymerase III Transcription Termination

RNA Polymerase III Transcription Termination
809
set RNA Polymerase III Transcription Termination
setSize 21
pANOVA 0.00454
s.dist -0.358
p.adjustANOVA 0.0235



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR3GL -10674.5
POLR3C -10385.0
POLR1D -10361.5
NFIA -10236.5
POLR1C -9763.0
POLR2E -9455.5
NFIX -9157.5
SSB -8451.5
POLR3H -8371.5
POLR2F -7875.0
NFIC -7400.5
POLR3E -7287.5
POLR2K -6878.5
POLR3G -6722.0
POLR2H -6204.5
POLR2L -4619.0
POLR3F -4498.5
POLR3K -3023.0
POLR3D -2707.0
POLR3A -1994.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR3GL -10674.5
POLR3C -10385.0
POLR1D -10361.5
NFIA -10236.5
POLR1C -9763.0
POLR2E -9455.5
NFIX -9157.5
SSB -8451.5
POLR3H -8371.5
POLR2F -7875.0
NFIC -7400.5
POLR3E -7287.5
POLR2K -6878.5
POLR3G -6722.0
POLR2H -6204.5
POLR2L -4619.0
POLR3F -4498.5
POLR3K -3023.0
POLR3D -2707.0
POLR3A -1994.5
CRCP 0.5


Cross-presentation of soluble exogenous antigens (endosomes)

Cross-presentation of soluble exogenous antigens (endosomes)
176
set Cross-presentation of soluble exogenous antigens (endosomes)
setSize 38
pANOVA 0.000137
s.dist -0.358
p.adjustANOVA 0.00171



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
PSMB5 -7321.5
PSMD3 -7295.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
PSMB5 -7321.5
PSMD3 -7295.5
MRC2 -7247.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation
860
set Regulation of activated PAK-2p34 by proteasome mediated degradation
setSize 42
pANOVA 6.12e-05
s.dist -0.357
p.adjustANOVA 0.000976



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PAK2 -5668.5
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


Regulation of PTEN stability and activity

Regulation of PTEN stability and activity
847
set Regulation of PTEN stability and activity
setSize 56
pANOVA 3.78e-06
s.dist -0.357
p.adjustANOVA 0.00016



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSNK2B -10802.5
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
TRIM27 -10115.5
PSMA3 -10042.5
PTEN -10039.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
AKT2 -9624.5
PSMD11 -9588.5
PSME1 -9572.5
RNF146 -9484.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSNK2B -10802.5
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
TRIM27 -10115.5
PSMA3 -10042.5
PTEN -10039.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
AKT2 -9624.5
PSMD11 -9588.5
PSME1 -9572.5
RNF146 -9484.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
TNKS -7902.5
TNKS2 -7808.5
STUB1 -7686.5
UBB -7535.5
WWP2 -7498.5
PSMB5 -7321.5
PSMD3 -7295.5
MKRN1 -7265.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
CSNK2A2 -5375.5
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
NEDD4 -4923.5
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
OTUD3 -2330.5
UBA52 -1275.5
AKT1 -1253.5
USP13 -648.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
1154
set Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
setSize 44
pANOVA 4.67e-05
s.dist -0.355
p.adjustANOVA 0.000851



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
CHEK1 -8910.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
CHEK1 -8910.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
CHEK2 -7643.0
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
CDC25A -2291.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


p53-Independent DNA Damage Response

p53-Independent DNA Damage Response
1190
set p53-Independent DNA Damage Response
setSize 44
pANOVA 4.67e-05
s.dist -0.355
p.adjustANOVA 0.000851



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
CHEK1 -8910.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
CHEK1 -8910.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
CHEK2 -7643.0
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
CDC25A -2291.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


p53-Independent G1/S DNA damage checkpoint

p53-Independent G1/S DNA damage checkpoint
1191
set p53-Independent G1/S DNA damage checkpoint
setSize 44
pANOVA 4.67e-05
s.dist -0.355
p.adjustANOVA 0.000851



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
CHEK1 -8910.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
CHEK1 -8910.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
CHEK2 -7643.0
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
CDC25A -2291.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)
1042
set Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize 10
pANOVA 0.0529
s.dist 0.353
p.adjustANOVA 0.149



Top enriched genes

Top 20 genes
GeneID Gene Rank
GGT1 976.5
ALOX5AP 816.5
PTGR1 0.5
LTA4H -798.5
LTC4S -871.5
CYP4F22 -1685.5
DPEP2 -1728.5
MAPKAPK2 -7380.5
ALOX5 -7529.5
ABCC1 -8704.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GGT1 976.5
ALOX5AP 816.5
PTGR1 0.5
LTA4H -798.5
LTC4S -871.5
CYP4F22 -1685.5
DPEP2 -1728.5
MAPKAPK2 -7380.5
ALOX5 -7529.5
ABCC1 -8704.5


Degradation of AXIN

Degradation of AXIN
218
set Degradation of AXIN
setSize 47
pANOVA 3.17e-05
s.dist -0.351
p.adjustANOVA 0.00072



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
RNF146 -9484.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
AXIN1 -8957.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
RNF146 -9484.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
AXIN1 -8957.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
TNKS -7902.5
TNKS2 -7808.5
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
AXIN2 -2511.5
SMURF2 -1848.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


Regulation of Apoptosis

Regulation of Apoptosis
834
set Regulation of Apoptosis
setSize 45
pANOVA 4.91e-05
s.dist -0.35
p.adjustANOVA 0.000867



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
OMA1 -9430.5
OPA1 -9344.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
OMA1 -9430.5
OPA1 -9344.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PAK2 -5668.5
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
UBA52 -1275.5
ARHGAP10 0.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


mRNA Capping

mRNA Capping
1181
set mRNA Capping
setSize 26
pANOVA 0.00203
s.dist -0.35
p.adjustANOVA 0.0133



Top enriched genes

Top 20 genes
GeneID Gene Rank
SUPT5H -10662.5
GTF2F2 -10444.5
POLR2A -10396.5
GTF2H5 -10238.0
GTF2H4 -10094.5
POLR2B -10064.5
NCBP2 -9490.5
POLR2E -9455.5
NCBP1 -8527.0
RNMT -8301.5
POLR2D -8055.5
POLR2F -7875.0
ERCC2 -7737.5
CDK7 -7413.5
POLR2K -6878.5
POLR2I -6700.0
POLR2H -6204.5
RNGTT -5724.5
GTF2H3 -5629.0
POLR2L -4619.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SUPT5H -10662.5
GTF2F2 -10444.5
POLR2A -10396.5
GTF2H5 -10238.0
GTF2H4 -10094.5
POLR2B -10064.5
NCBP2 -9490.5
POLR2E -9455.5
NCBP1 -8527.0
RNMT -8301.5
POLR2D -8055.5
POLR2F -7875.0
ERCC2 -7737.5
CDK7 -7413.5
POLR2K -6878.5
POLR2I -6700.0
POLR2H -6204.5
RNGTT -5724.5
GTF2H3 -5629.0
POLR2L -4619.0
CCNH -4485.5
GTF2F1 -3875.5
POLR2C -3765.5
ERCC3 -1373.5
POLR2G -827.5
MNAT1 -722.5


Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D
1155
set Ubiquitin-dependent degradation of Cyclin D
setSize 44
pANOVA 6.25e-05
s.dist -0.349
p.adjustANOVA 0.000976



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
CCND1 -9233.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
CCND1 -9233.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PSMB7 -5337.5
CDK4 -5178.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
GSK3B -2863.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


Postmitotic nuclear pore complex (NPC) reformation

Postmitotic nuclear pore complex (NPC) reformation
719
set Postmitotic nuclear pore complex (NPC) reformation
setSize 26
pANOVA 0.0021
s.dist -0.348
p.adjustANOVA 0.0135



Top enriched genes

Top 20 genes
GeneID Gene Rank
RCC1 -10317.5
NUP155 -9971.5
NUP85 -9899.5
NUP205 -9744.5
NUP37 -9693.5
NUP43 -9597.5
NUP188 -9303.0
NUP160 -8818.5
NUP107 -8791.5
NUP62 -8641.0
RANGAP1 -8286.5
UBE2I -7720.5
RAN -7575.5
NUP93 -7518.5
SEC13 -7055.5
NUP98 -6822.5
NUP133 -6499.5
TNPO1 -6189.5
AHCTF1 -5939.5
NUP35 -5630.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RCC1 -10317.5
NUP155 -9971.5
NUP85 -9899.5
NUP205 -9744.5
NUP37 -9693.5
NUP43 -9597.5
NUP188 -9303.0
NUP160 -8818.5
NUP107 -8791.5
NUP62 -8641.0
RANGAP1 -8286.5
UBE2I -7720.5
RAN -7575.5
NUP93 -7518.5
SEC13 -7055.5
NUP98 -6822.5
NUP133 -6499.5
TNPO1 -6189.5
AHCTF1 -5939.5
NUP35 -5630.5
POM121 -4767.5
KPNB1 -4423.5
NUP54 -3112.5
SEH1L -1747.5
SUMO1 -1305.5
NDC1 0.5


Caspase activation via Death Receptors in the presence of ligand

Caspase activation via Death Receptors in the presence of ligand
120
set Caspase activation via Death Receptors in the presence of ligand
setSize 10
pANOVA 0.0564
s.dist -0.348
p.adjustANOVA 0.156



Top enriched genes

Top 20 genes
GeneID Gene Rank
CASP8 -10707.5
CFLAR -10063.5
TICAM1 -8471.5
TNFRSF10A -7645.5
FAS -7460.0
FADD -6271.5
TRADD -5980.0
TNFSF10 -5582.5
TRAF2 -5002.5
TNFRSF10B -1828.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CASP8 -10707.5
CFLAR -10063.5
TICAM1 -8471.5
TNFRSF10A -7645.5
FAS -7460.0
FADD -6271.5
TRADD -5980.0
TNFSF10 -5582.5
TRAF2 -5002.5
TNFRSF10B -1828.5


Constitutive Signaling by EGFRvIII

Constitutive Signaling by EGFRvIII
168
set Constitutive Signaling by EGFRvIII
setSize 10
pANOVA 0.0578
s.dist -0.346
p.adjustANOVA 0.158



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDC37 -10184.0
HSP90AA1 -9625.5
PIK3CA -9239.5
PIK3R1 -8929.5
GRB2 -8360.5
SHC1 -7672.0
KRAS -7550.5
CBL -2893.5
PLCG1 -2890.5
HRAS -1555.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC37 -10184.0
HSP90AA1 -9625.5
PIK3CA -9239.5
PIK3R1 -8929.5
GRB2 -8360.5
SHC1 -7672.0
KRAS -7550.5
CBL -2893.5
PLCG1 -2890.5
HRAS -1555.5


Signaling by EGFRvIII in Cancer

Signaling by EGFRvIII in Cancer
958
set Signaling by EGFRvIII in Cancer
setSize 10
pANOVA 0.0578
s.dist -0.346
p.adjustANOVA 0.158



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDC37 -10184.0
HSP90AA1 -9625.5
PIK3CA -9239.5
PIK3R1 -8929.5
GRB2 -8360.5
SHC1 -7672.0
KRAS -7550.5
CBL -2893.5
PLCG1 -2890.5
HRAS -1555.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC37 -10184.0
HSP90AA1 -9625.5
PIK3CA -9239.5
PIK3R1 -8929.5
GRB2 -8360.5
SHC1 -7672.0
KRAS -7550.5
CBL -2893.5
PLCG1 -2890.5
HRAS -1555.5


Gap-filling DNA repair synthesis and ligation in GG-NER

Gap-filling DNA repair synthesis and ligation in GG-NER
368
set Gap-filling DNA repair synthesis and ligation in GG-NER
setSize 23
pANOVA 0.00452
s.dist -0.342
p.adjustANOVA 0.0235



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
RFC4 -10482.5
POLE3 -10181.0
POLK -10109.0
UBC -9774.5
RFC5 -9633.5
LIG1 -9338.5
RFC2 -8792.5
XRCC1 -8586.5
POLD4 -8576.5
POLD3 -8317.5
PCNA -7767.5
UBB -7535.5
LIG3 -7534.5
POLE -7002.0
POLE2 -6112.5
RPA3 -5701.5
POLE4 -5592.5
RPA1 -5561.0
UBA52 -1275.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
RFC4 -10482.5
POLE3 -10181.0
POLK -10109.0
UBC -9774.5
RFC5 -9633.5
LIG1 -9338.5
RFC2 -8792.5
XRCC1 -8586.5
POLD4 -8576.5
POLD3 -8317.5
PCNA -7767.5
UBB -7535.5
LIG3 -7534.5
POLE -7002.0
POLE2 -6112.5
RPA3 -5701.5
POLE4 -5592.5
RPA1 -5561.0
UBA52 -1275.5
POLD2 -684.5
POLD1 648.5
RFC3 851.5


Negative regulation of NOTCH4 signaling

Negative regulation of NOTCH4 signaling
620
set Negative regulation of NOTCH4 signaling
setSize 48
pANOVA 4.87e-05
s.dist -0.339
p.adjustANOVA 0.000867



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
NOTCH4 -10202.5
YWHAZ -10189.5
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
NOTCH4 -10202.5
YWHAZ -10189.5
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
PSMC3 -6852.5
TACC3 -6398.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
FBXW7 -5841.5
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
RBX1 -4979.5
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
SKP1 -2483.5
UBA52 -1275.5
AKT1 -1253.5
PSMF1 0.5
CUL1 0.5
PSMB2 0.5


Degradation of DVL

Degradation of DVL
219
set Degradation of DVL
setSize 48
pANOVA 5.13e-05
s.dist -0.338
p.adjustANOVA 0.000881



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
KLHL12 -9529.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
DVL2 -8892.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
KLHL12 -9529.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
DVL2 -8892.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
CUL3 -5771.5
DACT1 -5730.5
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
RBX1 -4979.5
PSMD9 -4574.5
PSMD1 -4416.5
DVL1 -4356.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
DVL3 -2441.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


Glycogen synthesis

Glycogen synthesis
388
set Glycogen synthesis
setSize 11
pANOVA 0.0533
s.dist -0.336
p.adjustANOVA 0.15



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
UGP2 -10320.5
PGM1 -9854.5
UBC -9774.5
PGM2L1 -8775.5
PGM2 -7597.5
UBB -7535.5
GYG1 -7180.5
GYS1 -3257.0
UBA52 -1275.5
NHLRC1 1192.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
UGP2 -10320.5
PGM1 -9854.5
UBC -9774.5
PGM2L1 -8775.5
PGM2 -7597.5
UBB -7535.5
GYG1 -7180.5
GYS1 -3257.0
UBA52 -1275.5
NHLRC1 1192.5


Assembly of the ORC complex at the origin of replication

Assembly of the ORC complex at the origin of replication
66
set Assembly of the ORC complex at the origin of replication
setSize 10
pANOVA 0.0655
s.dist 0.336
p.adjustANOVA 0.173



Top enriched genes

Top 20 genes
GeneID Gene Rank
ORC1 0.5
ORC3 0.5
KPNA1 -1649.5
ORC6 -1782.5
H2AFX -2458.5
ORC5 -2570.5
ORC4 -3228.0
ORC2 -3573.5
KPNB1 -4423.5
KPNA6 -8243.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC1 0.5
ORC3 0.5
KPNA1 -1649.5
ORC6 -1782.5
H2AFX -2458.5
ORC5 -2570.5
ORC4 -3228.0
ORC2 -3573.5
KPNB1 -4423.5
KPNA6 -8243.5


AUF1 (hnRNP D0) binds and destabilizes mRNA

AUF1 (hnRNP D0) binds and destabilizes mRNA
18
set AUF1 (hnRNP D0) binds and destabilizes mRNA
setSize 46
pANOVA 8.09e-05
s.dist -0.336
p.adjustANOVA 0.00119



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSPA1A -10807.0
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA1A -10807.0
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PABPC1 -5673.5
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
HSPB1 -4581.5
PSMD9 -4574.5
PSMD1 -4416.5
EIF4G1 -4408.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
HNRNPD -2048.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


Purine salvage

Purine salvage
745
set Purine salvage
setSize 11
pANOVA 0.0544
s.dist -0.335
p.adjustANOVA 0.153



Top enriched genes

Top 20 genes
GeneID Gene Rank
ADK -10772.5
GMPR2 -10715.0
AMPD2 -10428.5
PNP -9836.5
AMPD3 -7646.5
ADAL -6990.0
DCK -6100.5
DGUOK -4948.5
ADA -2968.5
APRT -2565.5
GMPR -2057.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADK -10772.5
GMPR2 -10715.0
AMPD2 -10428.5
PNP -9836.5
AMPD3 -7646.5
ADAL -6990.0
DCK -6100.5
DGUOK -4948.5
ADA -2968.5
APRT -2565.5
GMPR -2057.5


TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1058
set TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
setSize 13
pANOVA 0.0372
s.dist -0.334
p.adjustANOVA 0.114



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
TGFBR2 -10739.5
RHOA -10102.0
TGFB1 -9808.5
UBC -9774.5
F11R -8448.5
UBB -7535.5
FKBP1A -5588.5
PRKCZ -5486.5
TGFBR1 -4191.5
SMURF1 -3558.5
PARD6A -1310.0
UBA52 -1275.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
TGFBR2 -10739.5
RHOA -10102.0
TGFB1 -9808.5
UBC -9774.5
F11R -8448.5
UBB -7535.5
FKBP1A -5588.5
PRKCZ -5486.5
TGFBR1 -4191.5
SMURF1 -3558.5
PARD6A -1310.0
UBA52 -1275.5


Stabilization of p53

Stabilization of p53
1031
set Stabilization of p53
setSize 49
pANOVA 5.51e-05
s.dist -0.333
p.adjustANOVA 0.000919



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
TP53 -10761.0
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
TP53 -10761.0
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
ATM -8036.0
CHEK2 -7643.0
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
CDKN2A -7023.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PSMB7 -5337.5
MDM4 -5132.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PHF20 -4376.5
PSMD2 -3796.5
PSMD6 -3261.5
PSMC4 -2979.5
RFWD2 -2424.5
MDM2 -1715.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
PSME4 644.5


Aggrephagy

Aggrephagy
43
set Aggrephagy
setSize 19
pANOVA 0.012
s.dist -0.333
p.adjustANOVA 0.0484



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A -10747.5
UBE2V1 -10496.5
DYNLL1 -10088.5
UBC -9774.5
DYNC1LI1 -9653.5
HSP90AA1 -9625.5
DYNLL2 -9278.5
PARK7 -9085.5
UBE2N -7594.5
UBB -7535.5
DYNC1I2 -6269.5
DYNC1H1 -6159.5
PCNT -5264.0
ARL13B -5231.5
VCP -4953.5
DYNC1LI2 -4816.5
PARK2 -1504.0
UBA52 -1275.5
HSF1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A -10747.5
UBE2V1 -10496.5
DYNLL1 -10088.5
UBC -9774.5
DYNC1LI1 -9653.5
HSP90AA1 -9625.5
DYNLL2 -9278.5
PARK7 -9085.5
UBE2N -7594.5
UBB -7535.5
DYNC1I2 -6269.5
DYNC1H1 -6159.5
PCNT -5264.0
ARL13B -5231.5
VCP -4953.5
DYNC1LI2 -4816.5
PARK2 -1504.0
UBA52 -1275.5
HSF1 0.5


Regulation of RUNX3 expression and activity

Regulation of RUNX3 expression and activity
851
set Regulation of RUNX3 expression and activity
setSize 49
pANOVA 5.58e-05
s.dist -0.333
p.adjustANOVA 0.000919



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
TGFB1 -9808.5
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
CBFB -8423.5
PSMC1 -8232.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
TGFB1 -9808.5
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
CBFB -8423.5
PSMC1 -8232.5
EP300 -8181.5
PSMA7 -8171.5
PSMC6 -8047.5
UBB -7535.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
CDKN2A -7023.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
PSMB7 -5337.5
PSMD12 -5124.5
PSME2 -5054.0
SRC -4740.5
PSMD9 -4574.5
PSMD1 -4416.5
PSMD2 -3796.5
SMURF1 -3558.5
PSMD6 -3261.5
PSMC4 -2979.5
SMURF2 -1848.5
MDM2 -1715.5
UBA52 -1275.5
RUNX3 -1092.5
PSMF1 0.5
PSMB2 0.5


TRAF6 mediated NF-kB activation

TRAF6 mediated NF-kB activation
1077
set TRAF6 mediated NF-kB activation
setSize 19
pANOVA 0.0122
s.dist -0.332
p.adjustANOVA 0.049



Top enriched genes

Top 20 genes
GeneID Gene Rank
NKIRAS1 -10704.0
NFKBIA -10432.5
NFKB2 -10111.5
TRIM25 -10069.5
TRAF6 -9749.5
HMGB1 -9604.5
IFIH1 -9432.5
RNF135 -9332.5
MAVS -8630.5
NKIRAS2 -8143.5
DDX58 -7969.5
RELA -7257.5
TRAF2 -5002.5
NFKBIB -4436.5
APP -3929.5
IKBKB -3625.5
MAP3K1 -2581.5
TRIM4 872.5
CHUK 911.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NKIRAS1 -10704.0
NFKBIA -10432.5
NFKB2 -10111.5
TRIM25 -10069.5
TRAF6 -9749.5
HMGB1 -9604.5
IFIH1 -9432.5
RNF135 -9332.5
MAVS -8630.5
NKIRAS2 -8143.5
DDX58 -7969.5
RELA -7257.5
TRAF2 -5002.5
NFKBIB -4436.5
APP -3929.5
IKBKB -3625.5
MAP3K1 -2581.5
TRIM4 872.5
CHUK 911.5


p53-Dependent G1 DNA Damage Response

p53-Dependent G1 DNA Damage Response
1188
set p53-Dependent G1 DNA Damage Response
setSize 56
pANOVA 1.79e-05
s.dist -0.331
p.adjustANOVA 0.000553



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
TP53 -10761.0
CDKN1B -10751.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
CCNA2 -10534.5
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
CCNE1 -8939.5
PSMD7 -8700.5
PSMD4 -8442.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
TP53 -10761.0
CDKN1B -10751.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
CCNA2 -10534.5
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
CCNE1 -8939.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
ATM -8036.0
CHEK2 -7643.0
UBB -7535.5
PCBP4 -7506.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
CDKN2A -7023.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
CCNE2 -5795.5
PSMB7 -5337.5
MDM4 -5132.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PHF20 -4376.5
PSMD2 -3796.5
CDK2 -3492.5
PSMD6 -3261.5
PSMC4 -2979.5
RFWD2 -2424.5
MDM2 -1715.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
CDKN1A 0.5
PSME4 644.5


p53-Dependent G1/S DNA damage checkpoint

p53-Dependent G1/S DNA damage checkpoint
1189
set p53-Dependent G1/S DNA damage checkpoint
setSize 56
pANOVA 1.79e-05
s.dist -0.331
p.adjustANOVA 0.000553



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -10787.5
TP53 -10761.0
CDKN1B -10751.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
CCNA2 -10534.5
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
CCNE1 -8939.5
PSMD7 -8700.5
PSMD4 -8442.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -10787.5
TP53 -10761.0
CDKN1B -10751.5
RPS27A -10747.5
PSMA5 -10746.5
PSMC5 -10667.0
CCNA2 -10534.5
PSMB6 -10121.5
PSMA3 -10042.5
PSME3 -9890.5
PSMA2 -9850.0
UBC -9774.5
PSMD11 -9588.5
PSME1 -9572.5
PSMB3 -9451.5
PSMB9 -9306.5
PSMA6 -9160.5
CCNE1 -8939.5
PSMD7 -8700.5
PSMD4 -8442.5
PSMA1 -8439.5
PSMC1 -8232.5
PSMA7 -8171.5
PSMC6 -8047.5
ATM -8036.0
CHEK2 -7643.0
UBB -7535.5
PCBP4 -7506.5
PSMB5 -7321.5
PSMD3 -7295.5
PSMB10 -7211.5
CDKN2A -7023.5
PSMC3 -6852.5
PSMD14 -6378.5
PSMB1 -6275.0
PSMD8 -6270.5
PSMD13 -6198.0
CCNE2 -5795.5
PSMB7 -5337.5
MDM4 -5132.5
PSMD12 -5124.5
PSME2 -5054.0
PSMD9 -4574.5
PSMD1 -4416.5
PHF20 -4376.5
PSMD2 -3796.5
CDK2 -3492.5
PSMD6 -3261.5
PSMC4 -2979.5
RFWD2 -2424.5
MDM2 -1715.5
UBA52 -1275.5
PSMF1 0.5
PSMB2 0.5
CDKN1A 0.5
PSME4 644.5


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report