date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             metric
## TAP1    -10.858556
## ZFYVE28 -11.888316
## NOTCH4  -10.968930
## TRIM27  -15.120083
## PPT2     -9.783928
## PSMB9   -11.344900
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2546
num_genes_in_profile 12012
duplicated_genes_present 0
num_profile_genes_in_sets 5835
num_profile_genes_not_in_sets 6177

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2546
num_genesets_excluded 1344
num_genesets_included 1202

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Signaling by FGFR2 IIIa TM 15 0.000206 -0.553 0.00591
Processing of Intronless Pre-mRNAs 15 0.000923 -0.494 0.01320
FGFR2 mutant receptor activation 17 0.000569 -0.483 0.01140
Endosomal/Vacuolar pathway 10 0.009620 -0.473 0.05670
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 0.011600 -0.461 0.06220
Processing of Capped Intronless Pre-mRNA 23 0.000221 -0.445 0.00617
Signaling by FGFR2 in disease 24 0.000391 -0.418 0.00941
FGFR2 alternative splicing 22 0.000736 -0.416 0.01270
Generation of second messenger molecules 15 0.005340 0.415 0.04060
Sema4D induced cell migration and growth-cone collapse 12 0.013300 0.413 0.06850
Role of phospholipids in phagocytosis 16 0.005640 -0.400 0.04180
TNFR1-induced proapoptotic signaling 12 0.017000 -0.398 0.08130
TNFs bind their physiological receptors 10 0.031000 0.394 0.12200
Inhibition of DNA recombination at telomere 18 0.004150 -0.390 0.03450
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 26 0.000606 -0.388 0.01190
Abortive elongation of HIV-1 transcript in the absence of Tat 22 0.002350 -0.375 0.02670
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 0.020200 -0.372 0.09110
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 0.043000 -0.369 0.15200
alpha-linolenic acid (ALA) metabolism 10 0.043000 -0.369 0.15200
Gluconeogenesis 24 0.001910 -0.366 0.02370
Sema4D in semaphorin signaling 15 0.015000 0.363 0.07440
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 0.030200 -0.361 0.12000
Striated Muscle Contraction 10 0.049700 -0.358 0.16800
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 0.050700 0.357 0.17000
Other semaphorin interactions 10 0.050800 0.357 0.17000
Synthesis of glycosylphosphatidylinositol (GPI) 14 0.021000 -0.356 0.09290
mRNA Capping 26 0.001660 -0.356 0.02110
PIWI-interacting RNA (piRNA) biogenesis 16 0.013600 -0.356 0.06980
GAB1 signalosome 10 0.051200 -0.356 0.17000
Elevation of cytosolic Ca2+ levels 10 0.053500 -0.353 0.17500
Interleukin-6 signaling 10 0.054600 -0.351 0.17700
Interleukin-35 Signalling 11 0.045400 -0.348 0.15800
TRAF6 mediated IRF7 activation 16 0.017900 -0.342 0.08370
Defects in vitamin and cofactor metabolism 16 0.020400 -0.335 0.09140
Disorders of Developmental Biology 10 0.067400 -0.334 0.20300
Disorders of Nervous System Development 10 0.067400 -0.334 0.20300
Loss of function of MECP2 in Rett syndrome 10 0.067400 -0.334 0.20300
Pervasive developmental disorders 10 0.067400 -0.334 0.20300
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 0.068700 0.332 0.20400
Assembly of the ORC complex at the origin of replication 10 0.068700 0.332 0.20400
SUMOylation of immune response proteins 10 0.071600 -0.329 0.21000
Purine salvage 11 0.059100 -0.329 0.18600
Metabolism of folate and pterines 11 0.059600 -0.328 0.18800
Transport of Mature mRNAs Derived from Intronless Transcripts 41 0.000281 -0.328 0.00733
Purine ribonucleoside monophosphate biosynthesis 10 0.075200 -0.325 0.21700
Transport of Mature mRNA Derived from an Intronless Transcript 40 0.000380 -0.325 0.00932
MicroRNA (miRNA) biogenesis 21 0.010100 -0.324 0.05820
Sema3A PAK dependent Axon repulsion 11 0.062500 0.324 0.19400
Binding and Uptake of Ligands by Scavenger Receptors 10 0.080100 -0.320 0.22700
Deposition of new CENPA-containing nucleosomes at the centromere 23 0.008600 -0.316 0.05270


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Signaling by FGFR2 IIIa TM 15 2.06e-04 -0.553000 5.91e-03
Processing of Intronless Pre-mRNAs 15 9.23e-04 -0.494000 1.32e-02
FGFR2 mutant receptor activation 17 5.69e-04 -0.483000 1.14e-02
Endosomal/Vacuolar pathway 10 9.62e-03 -0.473000 5.67e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 1.16e-02 -0.461000 6.22e-02
Processing of Capped Intronless Pre-mRNA 23 2.21e-04 -0.445000 6.17e-03
Signaling by FGFR2 in disease 24 3.91e-04 -0.418000 9.41e-03
FGFR2 alternative splicing 22 7.36e-04 -0.416000 1.27e-02
Generation of second messenger molecules 15 5.34e-03 0.415000 4.06e-02
Sema4D induced cell migration and growth-cone collapse 12 1.33e-02 0.413000 6.85e-02
Role of phospholipids in phagocytosis 16 5.64e-03 -0.400000 4.18e-02
TNFR1-induced proapoptotic signaling 12 1.70e-02 -0.398000 8.13e-02
TNFs bind their physiological receptors 10 3.10e-02 0.394000 1.22e-01
Inhibition of DNA recombination at telomere 18 4.15e-03 -0.390000 3.45e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 26 6.06e-04 -0.388000 1.19e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 22 2.35e-03 -0.375000 2.67e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 2.02e-02 -0.372000 9.11e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 4.30e-02 -0.369000 1.52e-01
alpha-linolenic acid (ALA) metabolism 10 4.30e-02 -0.369000 1.52e-01
Gluconeogenesis 24 1.91e-03 -0.366000 2.37e-02
Sema4D in semaphorin signaling 15 1.50e-02 0.363000 7.44e-02
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 3.02e-02 -0.361000 1.20e-01
Striated Muscle Contraction 10 4.97e-02 -0.358000 1.68e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 5.07e-02 0.357000 1.70e-01
Other semaphorin interactions 10 5.08e-02 0.357000 1.70e-01
Synthesis of glycosylphosphatidylinositol (GPI) 14 2.10e-02 -0.356000 9.29e-02
mRNA Capping 26 1.66e-03 -0.356000 2.11e-02
PIWI-interacting RNA (piRNA) biogenesis 16 1.36e-02 -0.356000 6.98e-02
GAB1 signalosome 10 5.12e-02 -0.356000 1.70e-01
Elevation of cytosolic Ca2+ levels 10 5.35e-02 -0.353000 1.75e-01
Interleukin-6 signaling 10 5.46e-02 -0.351000 1.77e-01
Interleukin-35 Signalling 11 4.54e-02 -0.348000 1.58e-01
TRAF6 mediated IRF7 activation 16 1.79e-02 -0.342000 8.37e-02
Defects in vitamin and cofactor metabolism 16 2.04e-02 -0.335000 9.14e-02
Disorders of Developmental Biology 10 6.74e-02 -0.334000 2.03e-01
Disorders of Nervous System Development 10 6.74e-02 -0.334000 2.03e-01
Loss of function of MECP2 in Rett syndrome 10 6.74e-02 -0.334000 2.03e-01
Pervasive developmental disorders 10 6.74e-02 -0.334000 2.03e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 6.87e-02 0.332000 2.04e-01
Assembly of the ORC complex at the origin of replication 10 6.87e-02 0.332000 2.04e-01
SUMOylation of immune response proteins 10 7.16e-02 -0.329000 2.10e-01
Purine salvage 11 5.91e-02 -0.329000 1.86e-01
Metabolism of folate and pterines 11 5.96e-02 -0.328000 1.88e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 41 2.81e-04 -0.328000 7.33e-03
Purine ribonucleoside monophosphate biosynthesis 10 7.52e-02 -0.325000 2.17e-01
Transport of Mature mRNA Derived from an Intronless Transcript 40 3.80e-04 -0.325000 9.32e-03
MicroRNA (miRNA) biogenesis 21 1.01e-02 -0.324000 5.82e-02
Sema3A PAK dependent Axon repulsion 11 6.25e-02 0.324000 1.94e-01
Binding and Uptake of Ligands by Scavenger Receptors 10 8.01e-02 -0.320000 2.27e-01
Deposition of new CENPA-containing nucleosomes at the centromere 23 8.60e-03 -0.316000 5.27e-02
Nucleosome assembly 23 8.60e-03 -0.316000 5.27e-02
Peptide ligand-binding receptors 20 1.48e-02 0.315000 7.39e-02
RNA Pol II CTD phosphorylation and interaction with CE 24 8.33e-03 -0.311000 5.22e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 24 8.33e-03 -0.311000 5.22e-02
Sulfur amino acid metabolism 17 2.65e-02 -0.311000 1.10e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 5.28e-02 -0.310000 1.74e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 3.17e-02 -0.310000 1.23e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 3.17e-02 -0.310000 1.23e-01
HIV Transcription Initiation 39 8.69e-04 -0.308000 1.28e-02
RNA Polymerase II HIV Promoter Escape 39 8.69e-04 -0.308000 1.28e-02
RNA Polymerase II Promoter Escape 39 8.69e-04 -0.308000 1.28e-02
RNA Polymerase II Transcription Initiation 39 8.69e-04 -0.308000 1.28e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 39 8.69e-04 -0.308000 1.28e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 39 8.69e-04 -0.308000 1.28e-02
Triglyceride catabolism 11 8.10e-02 -0.304000 2.28e-01
Signaling by PDGFR in disease 15 4.24e-02 -0.303000 1.51e-01
tRNA Aminoacylation 23 1.29e-02 -0.300000 6.70e-02
TRAF3-dependent IRF activation pathway 14 5.28e-02 -0.299000 1.74e-01
Diseases associated with glycosylation precursor biosynthesis 15 4.65e-02 -0.297000 1.60e-01
Nucleotide salvage 18 2.94e-02 -0.296000 1.18e-01
Association of TriC/CCT with target proteins during biosynthesis 29 5.84e-03 -0.296000 4.30e-02
Viral Messenger RNA Synthesis 41 1.06e-03 -0.295000 1.44e-02
Mitochondrial Fatty Acid Beta-Oxidation 26 1.03e-02 -0.291000 5.83e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 8.14e-02 -0.290000 2.29e-01
Formation of the Early Elongation Complex 30 5.90e-03 -0.290000 4.30e-02
Formation of the HIV-1 Early Elongation Complex 30 5.90e-03 -0.290000 4.30e-02
Interleukin-7 signaling 14 6.02e-02 -0.290000 1.89e-01
RORA activates gene expression 11 9.62e-02 -0.290000 2.62e-01
HIV elongation arrest and recovery 27 9.22e-03 -0.290000 5.49e-02
Pausing and recovery of HIV elongation 27 9.22e-03 -0.290000 5.49e-02
Vitamin B5 (pantothenate) metabolism 11 9.70e-02 -0.289000 2.63e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 44 1.18e-03 -0.283000 1.53e-02
p53-Independent DNA Damage Response 44 1.18e-03 -0.283000 1.53e-02
p53-Independent G1/S DNA damage checkpoint 44 1.18e-03 -0.283000 1.53e-02
Mismatch Repair 13 7.84e-02 -0.282000 2.24e-01
Cross-presentation of soluble exogenous antigens (endosomes) 38 2.73e-03 -0.281000 3.04e-02
Degradation of cysteine and homocysteine 10 1.24e-01 -0.281000 3.11e-01
Glucose metabolism 72 4.84e-05 -0.277000 1.94e-03
Keratan sulfate/keratin metabolism 18 4.19e-02 -0.277000 1.50e-01
Mitochondrial tRNA aminoacylation 18 4.30e-02 -0.276000 1.52e-01
Degradation of GLI2 by the proteasome 50 7.69e-04 -0.275000 1.27e-02
GLI3 is processed to GLI3R by the proteasome 50 7.69e-04 -0.275000 1.27e-02
Rev-mediated nuclear export of HIV RNA 33 6.31e-03 -0.275000 4.47e-02
TNFR1-induced NFkappaB signaling pathway 20 3.37e-02 -0.274000 1.29e-01
B-WICH complex positively regulates rRNA expression 27 1.41e-02 -0.273000 7.13e-02
Signaling by FGFR in disease 39 3.22e-03 -0.273000 3.13e-02
Formation of HIV elongation complex in the absence of HIV Tat 37 4.12e-03 -0.273000 3.45e-02
RHO GTPases Activate ROCKs 13 9.10e-02 0.271000 2.51e-01
Interactions of Rev with host cellular proteins 34 6.41e-03 -0.270000 4.47e-02
Semaphorin interactions 39 3.66e-03 0.269000 3.38e-02
Transport of the SLBP Dependant Mature mRNA 34 6.67e-03 -0.269000 4.58e-02
Pausing and recovery of Tat-mediated HIV elongation 26 1.84e-02 -0.267000 8.55e-02
Tat-mediated HIV elongation arrest and recovery 26 1.84e-02 -0.267000 8.55e-02
Frs2-mediated activation 11 1.26e-01 0.267000 3.15e-01
Transcription of the HIV genome 57 5.14e-04 -0.266000 1.05e-02
Interactions of Vpr with host cellular proteins 33 8.34e-03 -0.265000 5.22e-02
Degradation of GLI1 by the proteasome 51 1.07e-03 -0.265000 1.44e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 4.06e-02 -0.265000 1.46e-01
Neurodegenerative Diseases 20 4.06e-02 -0.265000 1.46e-01
TRAF6 mediated NF-kB activation 19 4.59e-02 -0.264000 1.59e-01
Signaling by NTRK2 (TRKB) 15 7.65e-02 -0.264000 2.20e-01
Transport of the SLBP independent Mature mRNA 33 8.86e-03 -0.263000 5.38e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 16 6.95e-02 -0.262000 2.06e-01
Vpr-mediated nuclear import of PICs 32 1.06e-02 -0.261000 5.91e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 27 1.91e-02 -0.261000 8.80e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 26 2.15e-02 -0.260000 9.48e-02
Loss of Nlp from mitotic centrosomes 56 7.59e-04 -0.260000 1.27e-02
Loss of proteins required for interphase microtubule organization from the centrosome 56 7.59e-04 -0.260000 1.27e-02
Cell-cell junction organization 13 1.04e-01 0.260000 2.78e-01
RAF-independent MAPK1/3 activation 20 4.47e-02 -0.259000 1.56e-01
VEGFR2 mediated cell proliferation 16 7.30e-02 -0.259000 2.14e-01
Elastic fibre formation 17 6.52e-02 0.258000 2.00e-01
Ubiquitin-dependent degradation of Cyclin D 44 3.08e-03 -0.258000 3.08e-02
Rap1 signalling 11 1.39e-01 -0.257000 3.36e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 45 2.87e-03 -0.257000 3.04e-02
Regulation of PTEN stability and activity 56 9.16e-04 -0.256000 1.32e-02
Vif-mediated degradation of APOBEC3G 43 3.70e-03 -0.256000 3.39e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 36 7.90e-03 -0.256000 5.08e-02
HIV Transcription Elongation 36 7.90e-03 -0.256000 5.08e-02
Tat-mediated elongation of the HIV-1 transcript 36 7.90e-03 -0.256000 5.08e-02
VxPx cargo-targeting to cilium 16 7.71e-02 -0.255000 2.21e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 16 7.82e-02 -0.254000 2.24e-01
Early Phase of HIV Life Cycle 13 1.13e-01 -0.254000 2.92e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 1.48e-01 -0.252000 3.48e-01
Citric acid cycle (TCA cycle) 19 5.89e-02 -0.250000 1.86e-01
ER-Phagosome pathway 69 3.33e-04 -0.250000 8.35e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 3.43e-03 -0.250000 3.22e-02
Anchoring of the basal body to the plasma membrane 80 1.23e-04 -0.249000 3.79e-03
Interleukin-6 family signaling 13 1.21e-01 -0.249000 3.06e-01
RNA Polymerase II Pre-transcription Events 68 4.17e-04 -0.248000 9.63e-03
Heme signaling 26 3.02e-02 -0.246000 1.20e-01
Diseases associated with N-glycosylation of proteins 18 7.21e-02 -0.245000 2.11e-01
Platelet sensitization by LDL 13 1.27e-01 -0.245000 3.16e-01
Glycolysis 57 1.44e-03 -0.244000 1.84e-02
SUMOylation of intracellular receptors 19 6.55e-02 -0.244000 2.00e-01
ERKs are inactivated 11 1.62e-01 -0.244000 3.68e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 46 4.31e-03 -0.243000 3.52e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 88 8.45e-05 -0.243000 2.87e-03
Nonsense-Mediated Decay (NMD) 88 8.45e-05 -0.243000 2.87e-03
Degradation of AXIN 47 4.03e-03 -0.243000 3.45e-02
Thrombin signalling through proteinase activated receptors (PARs) 20 6.08e-02 0.242000 1.90e-01
Negative regulation of NOTCH4 signaling 48 3.83e-03 -0.241000 3.40e-02
Transcriptional regulation by small RNAs 45 5.20e-03 -0.241000 4.00e-02
TP53 Regulates Transcription of Cell Cycle Genes 43 6.56e-03 -0.240000 4.53e-02
Hedgehog ligand biogenesis 52 2.83e-03 -0.239000 3.04e-02
APC truncation mutants have impaired AXIN binding 12 1.53e-01 -0.238000 3.51e-01
AXIN missense mutants destabilize the destruction complex 12 1.53e-01 -0.238000 3.51e-01
Signaling by AMER1 mutants 12 1.53e-01 -0.238000 3.51e-01
Signaling by APC mutants 12 1.53e-01 -0.238000 3.51e-01
Signaling by AXIN mutants 12 1.53e-01 -0.238000 3.51e-01
Truncations of AMER1 destabilize the destruction complex 12 1.53e-01 -0.238000 3.51e-01
Beta-catenin phosphorylation cascade 15 1.12e-01 -0.237000 2.91e-01
Vpu mediated degradation of CD4 44 6.76e-03 -0.236000 4.62e-02
Autodegradation of the E3 ubiquitin ligase COP1 44 6.80e-03 -0.236000 4.62e-02
Export of Viral Ribonucleoproteins from Nucleus 31 2.31e-02 -0.236000 9.93e-02
Diseases associated with glycosaminoglycan metabolism 16 1.02e-01 -0.236000 2.75e-01
Synaptic adhesion-like molecules 10 1.97e-01 0.236000 4.17e-01
Formation of RNA Pol II elongation complex 50 3.97e-03 -0.236000 3.43e-02
RNA Polymerase II Transcription Elongation 50 3.97e-03 -0.236000 3.43e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 1.58e-01 -0.235000 3.62e-01
Downstream signal transduction 20 6.87e-02 -0.235000 2.04e-01
Resolution of Sister Chromatid Cohesion 92 9.94e-05 -0.235000 3.15e-03
Host Interactions of HIV factors 106 3.14e-05 -0.234000 1.30e-03
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 10 1.99e-01 0.234000 4.20e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 74 5.02e-04 -0.234000 1.04e-02
Class A/1 (Rhodopsin-like receptors) 49 4.63e-03 0.234000 3.66e-02
Antigen processing-Cross presentation 76 4.42e-04 -0.233000 1.00e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 83 2.51e-04 -0.233000 6.70e-03
Amplification of signal from the kinetochores 83 2.51e-04 -0.233000 6.70e-03
SCF(Skp2)-mediated degradation of p27/p21 52 3.72e-03 -0.233000 3.39e-02
Pyruvate metabolism and Citric Acid (TCA) cycle 41 1.03e-02 -0.232000 5.83e-02
Defective Intrinsic Pathway for Apoptosis 23 5.52e-02 -0.231000 1.78e-01
Nucleotide biosynthesis 12 1.66e-01 -0.231000 3.72e-01
SCF-beta-TrCP mediated degradation of Emi1 47 6.23e-03 -0.231000 4.47e-02
Regulation of expression of SLITs and ROBOs 124 9.57e-06 -0.231000 5.28e-04
Dual incision in TC-NER 56 2.88e-03 -0.230000 3.04e-02
AURKA Activation by TPX2 59 2.25e-03 -0.230000 2.60e-02
Defective pyroptosis 10 2.09e-01 -0.230000 4.32e-01
RAC3 GTPase cycle 59 2.33e-03 0.229000 2.67e-02
NEP/NS2 Interacts with the Cellular Export Machinery 30 2.99e-02 -0.229000 1.19e-01
Diseases of programmed cell death 37 1.61e-02 -0.229000 7.81e-02
Dectin-1 mediated noncanonical NF-kB signaling 52 4.43e-03 -0.228000 3.56e-02
Purine catabolism 10 2.13e-01 -0.227000 4.40e-01
Regulation of Apoptosis 45 8.42e-03 -0.227000 5.22e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 1.10e-02 -0.227000 6.08e-02
Long-term potentiation 11 1.97e-01 0.225000 4.17e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 23 6.22e-02 -0.225000 1.94e-01
Influenza Infection 130 1.02e-05 -0.225000 5.31e-04
Regulation of ornithine decarboxylase (ODC) 43 1.15e-02 -0.223000 6.22e-02
Signaling by FLT3 ITD and TKD mutants 12 1.81e-01 -0.223000 3.95e-01
NRIF signals cell death from the nucleus 14 1.50e-01 -0.222000 3.49e-01
Platelet calcium homeostasis 17 1.12e-01 -0.222000 2.91e-01
Regulation of PTEN mRNA translation 11 2.03e-01 0.221000 4.25e-01
Chromosome Maintenance 78 7.55e-04 -0.221000 1.27e-02
NIK–>noncanonical NF-kB signaling 51 6.41e-03 -0.221000 4.47e-02
Nuclear import of Rev protein 31 3.34e-02 -0.221000 1.29e-01
Negative regulators of DDX58/IFIH1 signaling 34 2.61e-02 -0.221000 1.08e-01
G-protein activation 13 1.69e-01 0.220000 3.75e-01
Synthesis of IP3 and IP4 in the cytosol 16 1.27e-01 -0.220000 3.17e-01
G1/S-Specific Transcription 27 4.79e-02 -0.220000 1.63e-01
Selenoamino acid metabolism 78 7.99e-04 -0.220000 1.28e-02
Regulation of IFNA/IFNB signaling 12 1.88e-01 -0.220000 4.05e-01
mRNA Splicing - Minor Pathway 49 8.10e-03 -0.219000 5.15e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 1.03e-02 -0.219000 5.83e-02
Regulation of RUNX2 expression and activity 57 4.40e-03 -0.218000 3.56e-02
Gap-filling DNA repair synthesis and ligation in TC-NER 55 5.23e-03 -0.218000 4.01e-02
Transport of Mature Transcript to Cytoplasm 64 2.62e-03 -0.218000 2.95e-02
HIV Life Cycle 129 2.04e-05 -0.218000 9.09e-04
Ion homeostasis 26 5.50e-02 -0.217000 1.78e-01
EML4 and NUDC in mitotic spindle formation 87 4.65e-04 -0.217000 1.02e-02
Transport of Ribonucleoproteins into the Host Nucleus 30 3.96e-02 -0.217000 1.44e-01
Gene Silencing by RNA 62 3.15e-03 -0.217000 3.10e-02
Base-Excision Repair, AP Site Formation 15 1.47e-01 -0.216000 3.48e-01
Influenza Viral RNA Transcription and Replication 113 7.63e-05 -0.216000 2.78e-03
ERK/MAPK targets 16 1.36e-01 -0.215000 3.33e-01
Late Phase of HIV Life Cycle 117 6.00e-05 -0.215000 2.33e-03
Ub-specific processing proteases 134 1.78e-05 -0.215000 8.56e-04
Polo-like kinase mediated events 15 1.50e-01 -0.215000 3.49e-01
RHOD GTPase cycle 36 2.65e-02 0.214000 1.10e-01
Ovarian tumor domain proteases 29 4.70e-02 -0.213000 1.61e-01
TBC/RABGAPs 40 1.99e-02 -0.213000 9.09e-02
Recruitment of NuMA to mitotic centrosomes 65 3.05e-03 -0.213000 3.08e-02
SUMOylation of SUMOylation proteins 32 3.76e-02 -0.212000 1.38e-01
CD28 dependent PI3K/Akt signaling 18 1.19e-01 -0.212000 3.03e-01
Asymmetric localization of PCP proteins 51 8.84e-03 -0.212000 5.38e-02
Eukaryotic Translation Termination 72 1.90e-03 -0.212000 2.37e-02
Diseases of DNA repair 45 1.41e-02 -0.212000 7.13e-02
HIV Infection 190 5.36e-07 -0.211000 8.06e-05
G1/S DNA Damage Checkpoints 58 5.50e-03 -0.211000 4.11e-02
Regulation of RAS by GAPs 56 6.40e-03 -0.211000 4.47e-02
Centrosome maturation 66 3.11e-03 -0.211000 3.08e-02
Recruitment of mitotic centrosome proteins and complexes 66 3.11e-03 -0.211000 3.08e-02
Diseases associated with O-glycosylation of proteins 21 9.53e-02 0.210000 2.60e-01
Eukaryotic Translation Elongation 72 2.10e-03 -0.210000 2.50e-02
HCMV Early Events 50 1.03e-02 -0.210000 5.83e-02
NS1 Mediated Effects on Host Pathways 38 2.58e-02 -0.209000 1.08e-01
Depolymerisation of the Nuclear Lamina 13 1.94e-01 0.208000 4.13e-01
Cargo trafficking to the periciliary membrane 40 2.31e-02 -0.208000 9.93e-02
Voltage gated Potassium channels 13 1.95e-01 0.207000 4.16e-01
Telomere C-strand (Lagging Strand) Synthesis 29 5.38e-02 -0.207000 1.75e-01
RNA Polymerase II Transcription Termination 45 1.64e-02 -0.207000 7.94e-02
mRNA decay by 5’ to 3’ exoribonuclease 15 1.66e-01 -0.207000 3.71e-01
Hh mutants abrogate ligand secretion 49 1.23e-02 -0.207000 6.53e-02
Degradation of beta-catenin by the destruction complex 68 3.32e-03 -0.206000 3.17e-02
Mitochondrial biogenesis 54 9.13e-03 -0.205000 5.49e-02
Activation of HOX genes during differentiation 41 2.33e-02 -0.205000 9.93e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 41 2.33e-02 -0.205000 9.93e-02
Mitotic Prometaphase 158 9.66e-06 -0.204000 5.28e-04
The role of GTSE1 in G2/M progression after G2 checkpoint 52 1.09e-02 -0.204000 6.04e-02
Separation of Sister Chromatids 147 2.03e-05 -0.204000 9.09e-04
Signaling by ALK 18 1.34e-01 -0.204000 3.30e-01
Cyclin E associated events during G1/S transition 72 2.88e-03 -0.203000 3.04e-02
Pyruvate metabolism 20 1.16e-01 -0.203000 2.96e-01
Selenocysteine synthesis 70 3.35e-03 -0.203000 3.17e-02
Cap-dependent Translation Initiation 95 6.49e-04 -0.203000 1.24e-02
Eukaryotic Translation Initiation 95 6.49e-04 -0.203000 1.24e-02
N-glycan antennae elongation in the medial/trans-Golgi 17 1.49e-01 -0.202000 3.49e-01
Peptide chain elongation 69 3.77e-03 -0.202000 3.40e-02
G2/M DNA damage checkpoint 54 1.04e-02 -0.202000 5.83e-02
Metabolism of carbohydrates 181 3.04e-06 -0.202000 2.61e-04
Notch-HLH transcription pathway 21 1.10e-01 -0.202000 2.87e-01
MAPK6/MAPK4 signaling 69 3.92e-03 -0.201000 3.43e-02
Regulation of RUNX3 expression and activity 49 1.50e-02 -0.201000 7.44e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 53 1.15e-02 -0.201000 6.22e-02
Cyclin A:Cdk2-associated events at S phase entry 74 2.87e-03 -0.201000 3.04e-02
Regulation of pyruvate dehydrogenase (PDH) complex 11 2.51e-01 -0.200000 4.80e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 28 6.76e-02 -0.200000 2.03e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 28 6.76e-02 -0.200000 2.03e-01
Cellular response to hypoxia 60 7.67e-03 -0.199000 5.07e-02
Hedgehog ‘on’ state 63 6.38e-03 -0.199000 4.47e-02
RNA polymerase II transcribes snRNA genes 71 3.85e-03 -0.199000 3.40e-02
RNA Polymerase III Transcription Termination 21 1.16e-01 -0.198000 2.96e-01
Downregulation of ERBB2:ERBB3 signaling 10 2.79e-01 0.198000 5.15e-01
Nuclear events mediated by NFE2L2 67 5.42e-03 -0.197000 4.07e-02
HDR through Single Strand Annealing (SSA) 35 4.44e-02 -0.196000 1.56e-01
COPI-mediated anterograde transport 71 4.28e-03 -0.196000 3.52e-02
Hh mutants are degraded by ERAD 47 2.01e-02 -0.196000 9.11e-02
Metabolism of water-soluble vitamins and cofactors 82 2.18e-03 -0.196000 2.57e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 69 5.01e-03 -0.196000 3.89e-02
Polymerase switching on the C-strand of the telomere 22 1.13e-01 -0.195000 2.91e-01
p53-Dependent G1 DNA Damage Response 56 1.16e-02 -0.195000 6.22e-02
p53-Dependent G1/S DNA damage checkpoint 56 1.16e-02 -0.195000 6.22e-02
RHO GTPases Activate Formins 102 6.79e-04 -0.195000 1.27e-02
Post-chaperonin tubulin folding pathway 13 2.24e-01 -0.195000 4.50e-01
Signaling by CSF3 (G-CSF) 24 9.87e-02 -0.195000 2.67e-01
CLEC7A (Dectin-1) signaling 84 2.06e-03 -0.195000 2.48e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 18 1.53e-01 -0.195000 3.51e-01
Signaling by Retinoic Acid 17 1.65e-01 -0.195000 3.71e-01
RNA Polymerase III Chain Elongation 17 1.65e-01 -0.194000 3.71e-01
FCERI mediated MAPK activation 23 1.08e-01 0.194000 2.83e-01
FCERI mediated NF-kB activation 64 7.46e-03 -0.194000 4.98e-02
Telomere Maintenance 57 1.16e-02 -0.193000 6.22e-02
Formation of a pool of free 40S subunits 78 3.25e-03 -0.193000 3.13e-02
UCH proteinases 74 4.15e-03 -0.193000 3.45e-02
Organelle biogenesis and maintenance 204 2.29e-06 -0.193000 2.29e-04
ABC transporter disorders 59 1.08e-02 -0.192000 5.99e-02
RUNX3 regulates NOTCH signaling 11 2.70e-01 -0.192000 5.08e-01
Unwinding of DNA 11 2.71e-01 -0.192000 5.08e-01
Inactivation of CSF3 (G-CSF) signaling 19 1.48e-01 -0.192000 3.49e-01
CTNNB1 S33 mutants aren’t phosphorylated 13 2.34e-01 -0.191000 4.57e-01
CTNNB1 S37 mutants aren’t phosphorylated 13 2.34e-01 -0.191000 4.57e-01
CTNNB1 S45 mutants aren’t phosphorylated 13 2.34e-01 -0.191000 4.57e-01
CTNNB1 T41 mutants aren’t phosphorylated 13 2.34e-01 -0.191000 4.57e-01
Signaling by CTNNB1 phospho-site mutants 13 2.34e-01 -0.191000 4.57e-01
Signaling by GSK3beta mutants 13 2.34e-01 -0.191000 4.57e-01
Retrograde transport at the Trans-Golgi-Network 45 2.69e-02 -0.191000 1.10e-01
Formation of TC-NER Pre-Incision Complex 46 2.54e-02 -0.191000 1.06e-01
Deubiquitination 198 4.10e-06 -0.190000 3.08e-04
Prolonged ERK activation events 13 2.35e-01 0.190000 4.59e-01
Defective CFTR causes cystic fibrosis 52 1.78e-02 -0.190000 8.37e-02
Triglyceride metabolism 16 1.88e-01 -0.190000 4.06e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 78 3.82e-03 -0.190000 3.40e-02
Signaling by ERBB2 ECD mutants 10 2.99e-01 -0.190000 5.35e-01
Hedgehog ‘off’ state 75 5.00e-03 -0.188000 3.89e-02
HCMV Infection 71 6.36e-03 -0.187000 4.47e-02
Degradation of DVL 48 2.48e-02 -0.187000 1.04e-01
Interleukin-1 signaling 79 4.07e-03 -0.187000 3.45e-02
Formation of tubulin folding intermediates by CCT/TriC 14 2.26e-01 -0.187000 4.53e-01
Viral mRNA Translation 69 7.39e-03 -0.187000 4.96e-02
Cilium Assembly 150 8.59e-05 -0.186000 2.87e-03
Stabilization of p53 49 2.46e-02 -0.186000 1.04e-01
Signaling by ROBO receptors 154 7.26e-05 -0.186000 2.73e-03
Caspase-mediated cleavage of cytoskeletal proteins 10 3.11e-01 0.185000 5.48e-01
tRNA processing in the nucleus 55 1.79e-02 -0.185000 8.37e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 88 2.83e-03 -0.184000 3.04e-02
Metabolism of polyamines 48 2.74e-02 -0.184000 1.12e-01
Estrogen-dependent gene expression 70 7.85e-03 -0.184000 5.08e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 19 1.65e-01 -0.184000 3.71e-01
ABC-family proteins mediated transport 74 6.43e-03 -0.183000 4.47e-02
Peroxisomal lipid metabolism 22 1.38e-01 -0.183000 3.33e-01
RUNX2 regulates osteoblast differentiation 13 2.55e-01 0.182000 4.85e-01
KEAP1-NFE2L2 pathway 86 3.53e-03 -0.182000 3.29e-02
Constitutive Signaling by EGFRvIII 10 3.19e-01 -0.182000 5.55e-01
Signaling by EGFRvIII in Cancer 10 3.19e-01 -0.182000 5.55e-01
SRP-dependent cotranslational protein targeting to membrane 88 3.25e-03 -0.182000 3.13e-02
Mitotic Spindle Checkpoint 98 1.98e-03 -0.181000 2.41e-02
Nuclear Receptor transcription pathway 27 1.04e-01 -0.181000 2.77e-01
Zinc transporters 12 2.79e-01 0.181000 5.15e-01
G1/S Transition 115 8.58e-04 -0.180000 1.28e-02
Azathioprine ADME 15 2.28e-01 -0.180000 4.55e-01
SHC1 events in ERBB2 signaling 11 3.02e-01 0.180000 5.38e-01
SUMOylation of ubiquitinylation proteins 37 5.91e-02 -0.179000 1.86e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 3.04e-01 -0.179000 5.41e-01
Methylation 10 3.27e-01 -0.179000 5.55e-01
G2/M Checkpoints 119 7.69e-04 -0.179000 1.27e-02
NCAM signaling for neurite out-growth 24 1.32e-01 0.178000 3.26e-01
Mitochondrial protein import 48 3.37e-02 -0.177000 1.29e-01
Ras activation upon Ca2+ influx through NMDA receptor 10 3.32e-01 0.177000 5.59e-01
ER Quality Control Compartment (ERQC) 18 1.95e-01 0.176000 4.15e-01
L13a-mediated translational silencing of Ceruloplasmin expression 87 4.52e-03 -0.176000 3.60e-02
Translation 238 3.07e-06 -0.176000 2.61e-04
DNA Damage/Telomere Stress Induced Senescence 24 1.37e-01 -0.176000 3.33e-01
Negative regulation of FLT3 13 2.73e-01 0.175000 5.10e-01
Signaling by FGFR2 48 3.58e-02 -0.175000 1.34e-01
mRNA 3’-end processing 37 6.54e-02 -0.175000 2.00e-01
Orc1 removal from chromatin 62 1.72e-02 -0.175000 8.23e-02
Nephrin family interactions 14 2.57e-01 -0.175000 4.89e-01
Drug ADME 27 1.16e-01 -0.175000 2.96e-01
DNA strand elongation 28 1.10e-01 -0.175000 2.87e-01
Regulation of PLK1 Activity at G2/M Transition 74 9.47e-03 -0.175000 5.61e-02
Signaling by NOTCH4 68 1.29e-02 -0.175000 6.70e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 29 1.04e-01 0.175000 2.77e-01
PRC2 methylates histones and DNA 12 2.96e-01 -0.174000 5.34e-01
TICAM1-dependent activation of IRF3/IRF7 12 2.96e-01 -0.174000 5.34e-01
Role of LAT2/NTAL/LAB on calcium mobilization 10 3.40e-01 -0.174000 5.63e-01
COPI-dependent Golgi-to-ER retrograde traffic 66 1.45e-02 -0.174000 7.31e-02
Metabolism of non-coding RNA 48 3.75e-02 -0.174000 1.38e-01
snRNP Assembly 48 3.75e-02 -0.174000 1.38e-01
Processive synthesis on the C-strand of the telomere 17 2.16e-01 -0.173000 4.43e-01
Cell Cycle Checkpoints 228 7.12e-06 -0.173000 4.51e-04
Nucleotide Excision Repair 99 3.01e-03 -0.173000 3.08e-02
Glyoxylate metabolism and glycine degradation 19 1.93e-01 -0.173000 4.12e-01
Circadian Clock 52 3.15e-02 -0.172000 1.23e-01
FCGR3A-mediated IL10 synthesis 22 1.63e-01 -0.172000 3.70e-01
SUMOylation of DNA replication proteins 43 5.30e-02 -0.171000 1.75e-01
Downstream TCR signaling 71 1.31e-02 -0.170000 6.80e-02
Golgi-to-ER retrograde transport 95 4.17e-03 -0.170000 3.45e-02
Cellular response to chemical stress 145 4.13e-04 -0.170000 9.63e-03
Cytoprotection by HMOX1 44 5.10e-02 -0.170000 1.70e-01
LDL clearance 12 3.09e-01 -0.170000 5.46e-01
DAG and IP3 signaling 26 1.38e-01 -0.168000 3.33e-01
Metabolism of vitamins and cofactors 111 2.25e-03 -0.168000 2.60e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 62 2.22e-02 -0.168000 9.67e-02
Glycogen synthesis 11 3.35e-01 -0.168000 5.62e-01
Collagen degradation 14 2.77e-01 0.168000 5.15e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 63 2.15e-02 -0.168000 9.48e-02
Mitotic G1 phase and G1/S transition 129 1.05e-03 -0.167000 1.44e-02
Activation of NF-kappaB in B cells 57 2.90e-02 -0.167000 1.17e-01
Formation of the ternary complex, and subsequently, the 43S complex 40 6.75e-02 -0.167000 2.03e-01
Potassium Channels 30 1.13e-01 0.167000 2.92e-01
Mitotic G2-G2/M phases 158 3.05e-04 -0.167000 7.81e-03
DDX58/IFIH1-mediated induction of interferon-alpha/beta 58 2.84e-02 -0.166000 1.16e-01
TP53 Regulates Transcription of DNA Repair Genes 52 3.83e-02 -0.166000 1.40e-01
Signaling by Hippo 12 3.20e-01 -0.166000 5.55e-01
RNA Polymerase III Abortive And Retractive Initiation 39 7.39e-02 -0.165000 2.14e-01
RNA Polymerase III Transcription 39 7.39e-02 -0.165000 2.14e-01
HCMV Late Events 51 4.13e-02 -0.165000 1.49e-01
Post-translational modification: synthesis of GPI-anchored proteins 31 1.11e-01 -0.165000 2.90e-01
InlB-mediated entry of Listeria monocytogenes into host cell 11 3.43e-01 -0.165000 5.66e-01
Mitochondrial iron-sulfur cluster biogenesis 12 3.23e-01 -0.165000 5.55e-01
Prefoldin mediated transfer of substrate to CCT/TriC 17 2.40e-01 -0.165000 4.62e-01
Constitutive Signaling by AKT1 E17K in Cancer 23 1.71e-01 -0.165000 3.80e-01
Cyclin A/B1/B2 associated events during G2/M transition 22 1.82e-01 -0.165000 3.96e-01
Glycosphingolipid metabolism 27 1.41e-01 -0.164000 3.39e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 88 8.04e-03 -0.164000 5.14e-02
RHOG GTPase cycle 49 4.78e-02 0.164000 1.63e-01
Lagging Strand Synthesis 17 2.44e-01 -0.163000 4.68e-01
RNA Polymerase I Promoter Escape 27 1.42e-01 -0.163000 3.40e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 57 3.32e-02 -0.163000 1.28e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 66 2.21e-02 -0.163000 9.65e-02
PKMTs methylate histone lysines 31 1.16e-01 0.163000 2.96e-01
Metabolism of amino acids and derivatives 225 2.77e-05 -0.163000 1.19e-03
RAC2 GTPase cycle 56 3.54e-02 0.163000 1.34e-01
Branched-chain amino acid catabolism 20 2.08e-01 -0.163000 4.32e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 65 2.39e-02 -0.162000 1.01e-01
Translesion synthesis by POLI 15 2.77e-01 -0.162000 5.15e-01
G2/M Transition 156 5.00e-04 -0.162000 1.04e-02
Mitotic Metaphase and Anaphase 196 9.97e-05 -0.162000 3.15e-03
Glutamate Neurotransmitter Release Cycle 12 3.32e-01 0.162000 5.59e-01
E3 ubiquitin ligases ubiquitinate target proteins 41 7.35e-02 -0.162000 2.14e-01
Energy dependent regulation of mTOR by LKB1-AMPK 25 1.63e-01 -0.161000 3.69e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 10 3.77e-01 -0.161000 6.00e-01
Regulation of APC/C activators between G1/S and early anaphase 70 1.99e-02 -0.161000 9.09e-02
Cleavage of the damaged pyrimidine 14 2.97e-01 -0.161000 5.34e-01
Depyrimidination 14 2.97e-01 -0.161000 5.34e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 14 2.97e-01 -0.161000 5.34e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 84 1.12e-02 -0.160000 6.14e-02
Recycling pathway of L1 15 2.83e-01 -0.160000 5.20e-01
COPI-independent Golgi-to-ER retrograde traffic 29 1.36e-01 -0.160000 3.33e-01
RNA Polymerase III Transcription Initiation 35 1.02e-01 -0.160000 2.74e-01
Postmitotic nuclear pore complex (NPC) reformation 26 1.60e-01 -0.159000 3.65e-01
Base Excision Repair 38 8.98e-02 -0.159000 2.48e-01
RAF activation 28 1.45e-01 -0.159000 3.46e-01
Mitotic Anaphase 195 1.44e-04 -0.158000 4.22e-03
Interleukin-20 family signaling 13 3.25e-01 -0.158000 5.55e-01
Metabolism of nucleotides 73 2.02e-02 -0.157000 9.11e-02
Processive synthesis on the lagging strand 13 3.26e-01 -0.157000 5.55e-01
Aggrephagy 19 2.37e-01 -0.157000 4.60e-01
Signaling by Hedgehog 99 7.14e-03 -0.157000 4.82e-02
Metabolism of porphyrins 15 2.94e-01 -0.156000 5.34e-01
Regulation of TP53 Activity through Phosphorylation 79 1.69e-02 -0.156000 8.13e-02
SARS-CoV-2-host interactions 150 1.08e-03 -0.155000 1.44e-02
M Phase 297 4.90e-06 -0.155000 3.46e-04
Interleukin-1 family signaling 99 7.88e-03 -0.155000 5.08e-02
AKT phosphorylates targets in the cytosol 13 3.35e-01 -0.154000 5.62e-01
ECM proteoglycans 13 3.35e-01 0.154000 5.62e-01
Activation of BH3-only proteins 27 1.67e-01 -0.154000 3.72e-01
Nuclear Pore Complex (NPC) Disassembly 34 1.22e-01 -0.153000 3.07e-01
APC/C-mediated degradation of cell cycle proteins 77 2.06e-02 -0.153000 9.17e-02
Regulation of mitotic cell cycle 77 2.06e-02 -0.153000 9.17e-02
The phototransduction cascade 18 2.62e-01 0.153000 4.95e-01
Mucopolysaccharidoses 10 4.04e-01 -0.152000 6.20e-01
Signaling by WNT in cancer 23 2.06e-01 -0.152000 4.30e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 55 5.09e-02 -0.152000 1.70e-01
RHOF GTPase cycle 25 1.90e-01 0.151000 4.08e-01
Interferon alpha/beta signaling 51 6.23e-02 -0.151000 1.94e-01
Disease 1086 1.90e-16 -0.151000 2.28e-13
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 16 2.96e-01 0.151000 5.34e-01
Resolution of Abasic Sites (AP sites) 31 1.47e-01 -0.151000 3.48e-01
Signaling by KIT in disease 16 2.97e-01 -0.150000 5.34e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 16 2.97e-01 -0.150000 5.34e-01
PINK1-PRKN Mediated Mitophagy 20 2.46e-01 -0.150000 4.71e-01
Cell junction organization 26 1.86e-01 0.150000 4.03e-01
Diseases of signal transduction by growth factor receptors and second messengers 299 9.49e-06 -0.150000 5.28e-04
The citric acid (TCA) cycle and respiratory electron transport 121 4.69e-03 -0.149000 3.68e-02
CDK-mediated phosphorylation and removal of Cdc6 62 4.25e-02 -0.149000 1.51e-01
Homologous DNA Pairing and Strand Exchange 39 1.08e-01 -0.149000 2.83e-01
Translation initiation complex formation 47 7.86e-02 -0.148000 2.24e-01
Arachidonic acid metabolism 21 2.40e-01 0.148000 4.62e-01
APC/C:Cdc20 mediated degradation of Securin 58 5.13e-02 -0.148000 1.70e-01
RHOH GTPase cycle 29 1.69e-01 0.148000 3.75e-01
Infectious disease 627 4.54e-10 -0.147000 1.36e-07
Ribosomal scanning and start codon recognition 47 8.05e-02 -0.147000 2.27e-01
Impaired BRCA2 binding to RAD51 32 1.49e-01 -0.147000 3.49e-01
HDR through Homologous Recombination (HRR) 60 4.85e-02 -0.147000 1.65e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 48 7.89e-02 -0.147000 2.24e-01
MHC class II antigen presentation 69 3.56e-02 -0.146000 1.34e-01
Autodegradation of Cdh1 by Cdh1:APC/C 56 5.83e-02 -0.146000 1.86e-01
Keratan sulfate biosynthesis 14 3.43e-01 -0.146000 5.66e-01
Molecules associated with elastic fibres 12 3.82e-01 0.146000 6.06e-01
RNA Polymerase I Transcription Termination 25 2.08e-01 -0.145000 4.32e-01
MAP2K and MAPK activation 25 2.09e-01 0.145000 4.32e-01
PCP/CE pathway 71 3.45e-02 -0.145000 1.32e-01
C-type lectin receptors (CLRs) 100 1.23e-02 -0.145000 6.53e-02
FLT3 signaling in disease 24 2.19e-01 -0.145000 4.46e-01
G0 and Early G1 24 2.20e-01 -0.145000 4.46e-01
Condensation of Prophase Chromosomes 12 3.86e-01 -0.145000 6.09e-01
PKA activation 10 4.31e-01 -0.144000 6.41e-01
Cell death signalling via NRAGE, NRIF and NADE 45 9.53e-02 -0.144000 2.60e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 48 8.53e-02 -0.144000 2.38e-01
DNA Double-Strand Break Repair 117 7.49e-03 -0.143000 4.98e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 77 2.98e-02 -0.143000 1.19e-01
Activation of gene expression by SREBF (SREBP) 36 1.37e-01 -0.143000 3.33e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 158 1.99e-03 -0.143000 2.41e-02
Downstream signaling of activated FGFR1 12 3.92e-01 -0.143000 6.11e-01
Downstream signaling of activated FGFR2 12 3.92e-01 -0.143000 6.11e-01
Downstream signaling of activated FGFR3 12 3.92e-01 -0.143000 6.11e-01
Downstream signaling of activated FGFR4 12 3.92e-01 -0.143000 6.11e-01
Cell Cycle 530 2.85e-08 -0.142000 5.70e-06
Homology Directed Repair 90 2.00e-02 -0.142000 9.10e-02
Disorders of transmembrane transporters 111 9.85e-03 -0.142000 5.77e-02
Factors involved in megakaryocyte development and platelet production 87 2.23e-02 -0.142000 9.67e-02
Cell Cycle, Mitotic 425 6.34e-07 -0.142000 8.47e-05
Signaling by FLT3 fusion proteins 16 3.26e-01 -0.142000 5.55e-01
DNA Repair 248 1.40e-04 -0.141000 4.22e-03
Processing of DNA double-strand break ends 55 7.10e-02 -0.141000 2.09e-01
N-Glycan antennae elongation 10 4.41e-01 -0.141000 6.51e-01
EPH-ephrin mediated repulsion of cells 25 2.24e-01 -0.141000 4.50e-01
ISG15 antiviral mechanism 70 4.25e-02 -0.140000 1.51e-01
Leading Strand Synthesis 12 4.00e-01 -0.140000 6.17e-01
Polymerase switching 12 4.00e-01 -0.140000 6.17e-01
SARS-CoV-2 modulates host translation machinery 39 1.30e-01 -0.140000 3.22e-01
G beta:gamma signalling through BTK 11 4.22e-01 0.140000 6.34e-01
TNFR2 non-canonical NF-kB pathway 68 4.65e-02 -0.140000 1.60e-01
IKK complex recruitment mediated by RIP1 17 3.19e-01 -0.140000 5.55e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 33 1.67e-01 -0.139000 3.72e-01
Adrenaline,noradrenaline inhibits insulin secretion 15 3.51e-01 0.139000 5.75e-01
Processing of Capped Intron-Containing Pre-mRNA 199 7.69e-04 -0.139000 1.27e-02
Signaling by PDGF 25 2.31e-01 -0.139000 4.57e-01
Interleukin-12 family signaling 42 1.23e-01 -0.138000 3.09e-01
Non-integrin membrane-ECM interactions 14 3.74e-01 0.137000 5.96e-01
Fatty acid metabolism 104 1.58e-02 -0.137000 7.71e-02
Nucleotide catabolism 21 2.80e-01 -0.136000 5.15e-01
Cellular response to starvation 120 1.01e-02 -0.136000 5.82e-02
S Phase 141 5.40e-03 -0.136000 4.07e-02
Signaling by FGFR 52 9.12e-02 -0.135000 2.51e-01
GPCR ligand binding 80 3.68e-02 0.135000 1.37e-01
TP53 Regulates Metabolic Genes 71 4.93e-02 -0.135000 1.67e-01
Signaling by Nuclear Receptors 151 4.44e-03 -0.134000 3.56e-02
Positive epigenetic regulation of rRNA expression 40 1.41e-01 -0.134000 3.39e-01
SARS-CoV-2 Infection 213 7.52e-04 -0.134000 1.27e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 64 6.38e-02 -0.134000 1.97e-01
ER to Golgi Anterograde Transport 108 1.74e-02 -0.133000 8.26e-02
Protein folding 63 6.88e-02 -0.133000 2.04e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 22 2.83e-01 -0.132000 5.20e-01
Signaling by cytosolic FGFR1 fusion mutants 16 3.60e-01 -0.132000 5.87e-01
Cholesterol biosynthesis 22 2.84e-01 -0.132000 5.21e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 3.93e-01 -0.132000 6.11e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 83 3.83e-02 -0.132000 1.40e-01
Membrane binding and targetting of GAG proteins 12 4.30e-01 -0.132000 6.41e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 4.30e-01 -0.132000 6.41e-01
Selective autophagy 50 1.08e-01 -0.131000 2.83e-01
Metabolism of fat-soluble vitamins 13 4.13e-01 -0.131000 6.25e-01
Signal transduction by L1 11 4.51e-01 0.131000 6.60e-01
Downstream signaling events of B Cell Receptor (BCR) 70 5.88e-02 -0.131000 1.86e-01
PI3K Cascade 19 3.24e-01 -0.131000 5.55e-01
Activation of BAD and translocation to mitochondria 14 3.98e-01 -0.131000 6.15e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 10 4.75e-01 -0.130000 6.82e-01
tRNA processing 93 3.06e-02 -0.130000 1.21e-01
CLEC7A (Dectin-1) induces NFAT activation 11 4.56e-01 -0.130000 6.65e-01
Peroxisomal protein import 48 1.22e-01 -0.129000 3.08e-01
IRS-related events triggered by IGF1R 22 2.95e-01 -0.129000 5.34e-01
Resolution of D-Loop Structures 29 2.30e-01 -0.129000 4.57e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 10 4.81e-01 -0.129000 6.86e-01
Transferrin endocytosis and recycling 19 3.32e-01 -0.129000 5.59e-01
Platelet degranulation 49 1.20e-01 -0.128000 3.04e-01
ZBP1(DAI) mediated induction of type I IFNs 17 3.61e-01 -0.128000 5.88e-01
Metabolism 1253 1.04e-13 -0.128000 6.24e-11
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 3.91e-01 -0.128000 6.11e-01
Transcriptional regulation by RUNX2 84 4.42e-02 -0.127000 1.55e-01
Telomere C-strand synthesis initiation 10 4.86e-01 -0.127000 6.92e-01
Interferon gamma signaling 55 1.03e-01 -0.127000 2.77e-01
Translation of Structural Proteins 27 2.54e-01 -0.127000 4.84e-01
FOXO-mediated transcription of cell death genes 14 4.11e-01 -0.127000 6.25e-01
G alpha (i) signalling events 93 3.55e-02 0.126000 1.34e-01
Presynaptic phase of homologous DNA pairing and strand exchange 36 1.90e-01 -0.126000 4.08e-01
Assembly and cell surface presentation of NMDA receptors 13 4.31e-01 0.126000 6.41e-01
Signaling by Activin 12 4.49e-01 0.126000 6.60e-01
Transcriptional Regulation by VENTX 30 2.33e-01 0.126000 4.57e-01
Neddylation 188 3.03e-03 -0.126000 3.08e-02
Regulation of TNFR1 signaling 31 2.26e-01 -0.126000 4.53e-01
Transport to the Golgi and subsequent modification 130 1.38e-02 -0.125000 7.03e-02
Glycogen metabolism 17 3.73e-01 -0.125000 5.96e-01
SARS-CoV Infections 270 4.53e-04 -0.125000 1.01e-02
G-protein mediated events 32 2.23e-01 -0.125000 4.50e-01
Dual Incision in GG-NER 35 2.04e-01 -0.124000 4.26e-01
p75 NTR receptor-mediated signalling 59 9.98e-02 -0.124000 2.69e-01
PKA-mediated phosphorylation of CREB 11 4.77e-01 -0.124000 6.83e-01
Respiratory electron transport 82 5.36e-02 -0.123000 1.75e-01
Hyaluronan uptake and degradation 10 4.99e-01 -0.123000 6.97e-01
Sphingolipid metabolism 49 1.36e-01 -0.123000 3.33e-01
Synthesis of DNA 106 2.91e-02 -0.123000 1.17e-01
Prostacyclin signalling through prostacyclin receptor 12 4.61e-01 0.123000 6.69e-01
Apoptosis 133 1.49e-02 -0.123000 7.43e-02
mRNA Splicing - Major Pathway 148 1.04e-02 -0.122000 5.83e-02
Metabolism of RNA 553 1.11e-06 -0.122000 1.33e-04
Translesion synthesis by REV1 14 4.28e-01 -0.122000 6.41e-01
Infection with Mycobacterium tuberculosis 22 3.21e-01 0.122000 5.55e-01
CD28 co-stimulation 27 2.73e-01 -0.122000 5.10e-01
TCF dependent signaling in response to WNT 119 2.20e-02 -0.122000 9.65e-02
Signaling by the B Cell Receptor (BCR) 90 4.64e-02 -0.122000 1.60e-01
SUMOylation of DNA methylation proteins 14 4.31e-01 0.121000 6.41e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 35 2.14e-01 -0.121000 4.40e-01
Signaling by EGFR 35 2.14e-01 -0.121000 4.40e-01
Signaling by MET 41 1.80e-01 -0.121000 3.93e-01
Diseases of metabolism 126 1.91e-02 -0.121000 8.80e-02
Inwardly rectifying K+ channels 13 4.50e-01 0.121000 6.60e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 4.34e-01 -0.121000 6.43e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 4.34e-01 -0.121000 6.43e-01
MyD88-independent TLR4 cascade 74 7.39e-02 -0.120000 2.14e-01
TRIF(TICAM1)-mediated TLR4 signaling 74 7.39e-02 -0.120000 2.14e-01
SARS-CoV-2 modulates autophagy 11 4.90e-01 -0.120000 6.94e-01
Intrinsic Pathway for Apoptosis 47 1.54e-01 -0.120000 3.54e-01
BBSome-mediated cargo-targeting to cilium 19 3.66e-01 -0.120000 5.91e-01
Switching of origins to a post-replicative state 81 6.29e-02 -0.120000 1.95e-01
Transcription of E2F targets under negative control by DREAM complex 18 3.80e-01 -0.120000 6.03e-01
Toll Like Receptor 4 (TLR4) Cascade 94 4.54e-02 -0.120000 1.58e-01
Response to elevated platelet cytosolic Ca2+ 53 1.33e-01 -0.120000 3.27e-01
RAC1 GTPase cycle 110 3.12e-02 0.119000 1.22e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 24 3.15e-01 -0.119000 5.53e-01
Heparan sulfate/heparin (HS-GAG) metabolism 22 3.36e-01 -0.119000 5.62e-01
Diseases of glycosylation 69 8.89e-02 -0.119000 2.47e-01
ATF4 activates genes in response to endoplasmic reticulum stress 23 3.25e-01 -0.118000 5.55e-01
Formation of Incision Complex in GG-NER 36 2.19e-01 -0.118000 4.46e-01
ESR-mediated signaling 115 2.86e-02 -0.118000 1.16e-01
Negative regulation of MAPK pathway 36 2.20e-01 -0.118000 4.46e-01
Phase II - Conjugation of compounds 46 1.66e-01 -0.118000 3.71e-01
Negative epigenetic regulation of rRNA expression 44 1.76e-01 -0.118000 3.87e-01
Signaling by EGFR in Cancer 16 4.14e-01 -0.118000 6.25e-01
Major pathway of rRNA processing in the nucleolus and cytosol 152 1.25e-02 -0.118000 6.59e-02
PCNA-Dependent Long Patch Base Excision Repair 18 3.88e-01 -0.118000 6.09e-01
FGFR1 mutant receptor activation 20 3.63e-01 -0.118000 5.89e-01
CaM pathway 20 3.63e-01 -0.117000 5.89e-01
Calmodulin induced events 20 3.63e-01 -0.117000 5.89e-01
Cellular responses to stimuli 551 3.26e-06 -0.117000 2.61e-04
MET promotes cell motility 13 4.65e-01 -0.117000 6.73e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 28 2.86e-01 -0.117000 5.23e-01
Signaling by NOTCH2 18 3.94e-01 -0.116000 6.12e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 37 2.22e-01 -0.116000 4.49e-01
Diseases of DNA Double-Strand Break Repair 37 2.22e-01 -0.116000 4.49e-01
TNF signaling 38 2.16e-01 -0.116000 4.43e-01
Cell surface interactions at the vascular wall 56 1.34e-01 0.116000 3.30e-01
RAS processing 15 4.39e-01 -0.115000 6.49e-01
Metabolism of steroids 86 6.47e-02 -0.115000 1.99e-01
Asparagine N-linked glycosylation 225 3.03e-03 -0.115000 3.08e-02
RET signaling 23 3.40e-01 -0.115000 5.63e-01
MTOR signalling 36 2.33e-01 -0.115000 4.57e-01
Signaling by NTRK3 (TRKC) 11 5.09e-01 -0.115000 7.04e-01
G beta:gamma signalling through PLC beta 13 4.74e-01 0.115000 6.81e-01
Presynaptic function of Kainate receptors 13 4.74e-01 0.115000 6.81e-01
rRNA processing in the nucleus and cytosol 159 1.29e-02 -0.115000 6.70e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 5.11e-01 -0.115000 7.04e-01
Signaling by Leptin 10 5.30e-01 0.115000 7.22e-01
Metabolism of proteins 1246 3.27e-11 -0.114000 1.31e-08
Heme biosynthesis 10 5.31e-01 -0.114000 7.22e-01
Removal of the Flap Intermediate 12 4.93e-01 -0.114000 6.97e-01
DNA Damage Bypass 42 2.00e-01 -0.114000 4.21e-01
Plasma lipoprotein assembly, remodeling, and clearance 39 2.18e-01 -0.114000 4.45e-01
Mitophagy 25 3.24e-01 -0.114000 5.55e-01
Apoptotic cleavage of cellular proteins 25 3.24e-01 0.114000 5.55e-01
Inactivation, recovery and regulation of the phototransduction cascade 17 4.17e-01 0.114000 6.28e-01
Antiviral mechanism by IFN-stimulated genes 77 8.48e-02 -0.114000 2.37e-01
Cellular responses to stress 546 6.97e-06 -0.114000 4.51e-04
Class I MHC mediated antigen processing & presentation 289 9.51e-04 -0.114000 1.35e-02
DNA Replication 113 3.78e-02 -0.113000 1.38e-01
ABC transporters in lipid homeostasis 10 5.35e-01 0.113000 7.26e-01
Protein localization 123 3.06e-02 -0.113000 1.21e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 61 1.28e-01 -0.113000 3.18e-01
Global Genome Nucleotide Excision Repair (GG-NER) 76 8.96e-02 -0.113000 2.48e-01
Complex I biogenesis 43 2.02e-01 -0.113000 4.23e-01
Synthesis of very long-chain fatty acyl-CoAs 16 4.36e-01 0.112000 6.45e-01
IGF1R signaling cascade 23 3.51e-01 -0.112000 5.75e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 23 3.51e-01 -0.112000 5.75e-01
Collagen biosynthesis and modifying enzymes 19 3.96e-01 0.112000 6.14e-01
rRNA processing 164 1.33e-02 -0.112000 6.85e-02
mRNA Splicing 158 1.52e-02 -0.112000 7.47e-02
Response of Mtb to phagocytosis 20 3.86e-01 0.112000 6.09e-01
Transcriptional Regulation by TP53 302 8.72e-04 -0.112000 1.28e-02
p75NTR signals via NF-kB 11 5.20e-01 -0.112000 7.13e-01
Chaperonin-mediated protein folding 57 1.46e-01 -0.112000 3.46e-01
Extension of Telomeres 44 2.02e-01 -0.111000 4.23e-01
Activation of G protein gated Potassium channels 12 5.04e-01 0.111000 6.99e-01
G protein gated Potassium channels 12 5.04e-01 0.111000 6.99e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 12 5.04e-01 0.111000 6.99e-01
Transcriptional regulation by RUNX3 75 9.66e-02 -0.111000 2.62e-01
Initiation of Nuclear Envelope (NE) Reformation 17 4.30e-01 0.111000 6.41e-01
Protein ubiquitination 59 1.43e-01 -0.110000 3.42e-01
Pyroptosis 18 4.18e-01 -0.110000 6.30e-01
Interleukin-4 and Interleukin-13 signaling 49 1.83e-01 -0.110000 3.97e-01
DAP12 interactions 21 3.84e-01 -0.110000 6.09e-01
PLC beta mediated events 29 3.10e-01 -0.109000 5.46e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 21 3.88e-01 -0.109000 6.09e-01
Diseases of carbohydrate metabolism 23 3.67e-01 -0.109000 5.92e-01
PERK regulates gene expression 26 3.40e-01 -0.108000 5.63e-01
Condensation of Prometaphase Chromosomes 10 5.55e-01 -0.108000 7.41e-01
SUMOylation of RNA binding proteins 42 2.27e-01 -0.108000 4.54e-01
HDACs deacetylate histones 28 3.24e-01 -0.108000 5.55e-01
Assembly of the pre-replicative complex 76 1.05e-01 -0.108000 2.79e-01
HSF1 activation 21 3.94e-01 -0.107000 6.12e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 16 4.57e-01 0.107000 6.65e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 23 3.75e-01 -0.107000 5.98e-01
Programmed Cell Death 155 2.32e-02 -0.106000 9.93e-02
Gene expression (Transcription) 1040 1.71e-08 -0.106000 4.11e-06
Nuclear Events (kinase and transcription factor activation) 42 2.39e-01 -0.105000 4.62e-01
Plasma lipoprotein clearance 24 3.73e-01 -0.105000 5.96e-01
Oncogenic MAPK signaling 56 1.76e-01 -0.104000 3.87e-01
Activation of kainate receptors upon glutamate binding 17 4.56e-01 0.104000 6.65e-01
Hyaluronan metabolism 11 5.49e-01 -0.104000 7.41e-01
IRS-mediated signalling 21 4.10e-01 -0.104000 6.25e-01
HATs acetylate histones 63 1.56e-01 -0.103000 3.58e-01
Diseases associated with the TLR signaling cascade 17 4.61e-01 -0.103000 6.69e-01
Diseases of Immune System 17 4.61e-01 -0.103000 6.69e-01
Meiosis 42 2.48e-01 -0.103000 4.75e-01
Post-translational protein modification 917 2.07e-07 -0.103000 3.55e-05
RHO GTPase Effectors 188 1.54e-02 -0.103000 7.57e-02
Recognition of DNA damage by PCNA-containing replication complex 26 3.68e-01 -0.102000 5.93e-01
Insulin receptor recycling 17 4.68e-01 -0.102000 6.74e-01
Interferon Signaling 142 3.68e-02 -0.102000 1.37e-01
G beta:gamma signalling through CDC42 13 5.27e-01 0.101000 7.19e-01
Ion transport by P-type ATPases 27 3.63e-01 -0.101000 5.89e-01
Meiotic recombination 19 4.47e-01 -0.101000 6.58e-01
O-linked glycosylation 42 2.63e-01 0.099900 4.95e-01
G alpha (q) signalling events 78 1.28e-01 0.099900 3.18e-01
ADP signalling through P2Y purinoceptor 1 16 4.89e-01 0.099800 6.94e-01
Activation of ATR in response to replication stress 36 3.00e-01 -0.099800 5.36e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 12 5.50e-01 0.099600 7.41e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 5.51e-01 -0.099300 7.41e-01
Chaperone Mediated Autophagy 12 5.52e-01 -0.099200 7.41e-01
Antigen processing: Ubiquitination & Proteasome degradation 241 8.42e-03 -0.098900 5.22e-02
RNA Polymerase I Transcription Initiation 40 2.79e-01 -0.098900 5.15e-01
Termination of translesion DNA synthesis 28 3.66e-01 -0.098800 5.91e-01
Metabolism of cofactors 17 4.84e-01 -0.098100 6.89e-01
Kinesins 32 3.37e-01 -0.098100 5.63e-01
Synthesis of bile acids and bile salts 13 5.41e-01 -0.098000 7.32e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 26 3.88e-01 -0.097800 6.09e-01
Iron uptake and transport 38 3.00e-01 -0.097200 5.36e-01
Diseases of mitotic cell cycle 34 3.27e-01 -0.097100 5.55e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 33 3.36e-01 -0.096700 5.62e-01
Toll Like Receptor 3 (TLR3) Cascade 74 1.51e-01 -0.096700 3.51e-01
DNA Replication Pre-Initiation 90 1.14e-01 -0.096500 2.93e-01
Signaling by FGFR1 in disease 24 4.13e-01 -0.096400 6.25e-01
MyD88 dependent cascade initiated on endosome 67 1.73e-01 -0.096300 3.82e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 67 1.73e-01 -0.096300 3.82e-01
Vesicle-mediated transport 454 4.91e-04 -0.096200 1.04e-02
SUMO E3 ligases SUMOylate target proteins 132 5.89e-02 -0.095400 1.86e-01
Thromboxane signalling through TP receptor 15 5.22e-01 0.095400 7.15e-01
Death Receptor Signalling 96 1.08e-01 -0.095100 2.83e-01
Transcriptional activation of mitochondrial biogenesis 40 2.99e-01 -0.095000 5.35e-01
Translesion Synthesis by POLH 17 4.98e-01 -0.095000 6.97e-01
RNA Polymerase II Transcription 927 1.47e-06 -0.095000 1.61e-04
Potential therapeutics for SARS 66 1.83e-01 -0.094900 3.97e-01
Metabolism of steroid hormones 13 5.53e-01 -0.094900 7.41e-01
Golgi Associated Vesicle Biogenesis 38 3.11e-01 -0.094900 5.48e-01
Interleukin-12 signaling 36 3.27e-01 -0.094500 5.55e-01
Synthesis of substrates in N-glycan biosythesis 48 2.58e-01 -0.094400 4.90e-01
RND2 GTPase cycle 34 3.43e-01 -0.093900 5.66e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 33 3.51e-01 0.093900 5.75e-01
MAPK family signaling cascades 191 2.66e-02 -0.093300 1.10e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 27 4.01e-01 -0.093300 6.18e-01
RHO GTPases activate PAKs 13 5.61e-01 0.093200 7.45e-01
Anti-inflammatory response favouring Leishmania parasite infection 54 2.40e-01 -0.092600 4.62e-01
Leishmania parasite growth and survival 54 2.40e-01 -0.092600 4.62e-01
MyD88 cascade initiated on plasma membrane 65 1.98e-01 -0.092400 4.18e-01
Toll Like Receptor 10 (TLR10) Cascade 65 1.98e-01 -0.092400 4.18e-01
Toll Like Receptor 5 (TLR5) Cascade 65 1.98e-01 -0.092400 4.18e-01
RUNX2 regulates bone development 18 5.00e-01 0.091800 6.97e-01
Generic Transcription Pathway 826 1.06e-05 -0.091600 5.31e-04
Membrane Trafficking 446 1.03e-03 -0.091400 1.44e-02
Reproduction 48 2.78e-01 -0.090600 5.15e-01
Regulation of innate immune responses to cytosolic DNA 12 5.88e-01 0.090400 7.65e-01
Regulation of TP53 Activity 136 7.08e-02 -0.089900 2.09e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 41 3.19e-01 -0.089900 5.55e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 41 3.19e-01 -0.089900 5.55e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 41 3.19e-01 -0.089900 5.55e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 41 3.19e-01 -0.089900 5.55e-01
Signaling by NOTCH1 in Cancer 41 3.19e-01 -0.089900 5.55e-01
Cytochrome c-mediated apoptotic response 11 6.09e-01 0.089200 7.81e-01
Mitochondrial translation 89 1.47e-01 -0.089000 3.48e-01
PI3K/AKT Signaling in Cancer 52 2.68e-01 -0.088900 5.04e-01
NoRC negatively regulates rRNA expression 42 3.20e-01 -0.088700 5.55e-01
Inositol phosphate metabolism 30 4.03e-01 -0.088300 6.19e-01
Cyclin D associated events in G1 41 3.31e-01 -0.087800 5.59e-01
G1 Phase 41 3.31e-01 -0.087800 5.59e-01
GPCR downstream signalling 197 3.48e-02 0.087500 1.32e-01
MAPK1/MAPK3 signaling 164 5.42e-02 -0.087400 1.76e-01
FOXO-mediated transcription 46 3.06e-01 -0.087200 5.43e-01
Unfolded Protein Response (UPR) 76 1.89e-01 -0.087100 4.07e-01
SARS-CoV-1 Infection 46 3.08e-01 -0.087000 5.45e-01
Assembly Of The HIV Virion 14 5.74e-01 -0.086800 7.56e-01
Removal of the Flap Intermediate from the C-strand 15 5.61e-01 -0.086700 7.45e-01
DNA Double Strand Break Response 36 3.68e-01 -0.086600 5.93e-01
Interleukin-15 signaling 11 6.19e-01 -0.086600 7.91e-01
Miscellaneous transport and binding events 14 5.75e-01 -0.086600 7.56e-01
Ca-dependent events 21 4.94e-01 -0.086300 6.97e-01
Peptide hormone metabolism 31 4.07e-01 0.086000 6.25e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 66 2.28e-01 -0.085900 4.55e-01
Glutathione conjugation 21 4.96e-01 -0.085800 6.97e-01
Transport of vitamins, nucleosides, and related molecules 21 4.97e-01 -0.085600 6.97e-01
Integrin signaling 16 5.53e-01 -0.085600 7.41e-01
Platelet Aggregation (Plug Formation) 16 5.53e-01 -0.085600 7.41e-01
Mitochondrial translation initiation 84 1.78e-01 -0.085100 3.90e-01
Detoxification of Reactive Oxygen Species 23 4.81e-01 -0.084900 6.86e-01
Regulated Necrosis 43 3.38e-01 -0.084400 5.63e-01
SLC transporter disorders 52 2.95e-01 -0.083900 5.34e-01
SUMOylation of DNA damage response and repair proteins 67 2.37e-01 -0.083600 4.60e-01
Erythropoietin activates RAS 10 6.49e-01 0.083200 8.13e-01
RNA Polymerase I Promoter Clearance 44 3.40e-01 -0.083200 5.63e-01
RNA Polymerase I Transcription 44 3.40e-01 -0.083200 5.63e-01
XBP1(S) activates chaperone genes 42 3.52e-01 -0.083000 5.76e-01
SUMOylation 138 9.35e-02 -0.082900 2.57e-01
Signaling by WNT 177 5.88e-02 -0.082600 1.86e-01
Toll-like Receptor Cascades 108 1.40e-01 -0.082200 3.38e-01
Autophagy 106 1.45e-01 -0.082100 3.45e-01
Pre-NOTCH Processing in Golgi 16 5.71e-01 -0.081700 7.54e-01
Regulation of TP53 Activity through Acetylation 27 4.62e-01 -0.081700 6.70e-01
Macroautophagy 97 1.65e-01 -0.081700 3.71e-01
Sialic acid metabolism 23 4.98e-01 -0.081600 6.97e-01
Signaling by NTRK1 (TRKA) 79 2.10e-01 -0.081600 4.34e-01
Glycosaminoglycan metabolism 64 2.59e-01 -0.081600 4.91e-01
RHOV GTPase cycle 28 4.55e-01 -0.081500 6.65e-01
Insulin processing 17 5.62e-01 -0.081300 7.45e-01
Signaling by NOTCH 135 1.06e-01 -0.080800 2.80e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 20 5.34e-01 -0.080400 7.25e-01
trans-Golgi Network Vesicle Budding 51 3.24e-01 -0.079900 5.55e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 5.92e-01 -0.079800 7.71e-01
TICAM1, RIP1-mediated IKK complex recruitment 17 5.69e-01 -0.079800 7.53e-01
Epigenetic regulation of gene expression 76 2.32e-01 -0.079400 4.57e-01
Regulation of HSF1-mediated heat shock response 67 2.63e-01 -0.079200 4.95e-01
RHO GTPases activate CIT 14 6.08e-01 -0.079100 7.81e-01
Meiotic synapsis 25 4.98e-01 -0.078400 6.97e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 27 4.81e-01 -0.078300 6.86e-01
Signaling by NODAL 12 6.40e-01 0.077900 8.09e-01
Fcgamma receptor (FCGR) dependent phagocytosis 62 2.90e-01 -0.077800 5.28e-01
CDC42 GTPase cycle 97 1.86e-01 0.077700 4.03e-01
Signaling by ERBB2 KD Mutants 12 6.42e-01 -0.077500 8.09e-01
NOTCH1 Intracellular Domain Regulates Transcription 37 4.15e-01 -0.077500 6.25e-01
Intracellular signaling by second messengers 210 5.37e-02 -0.077500 1.75e-01
Beta-catenin independent WNT signaling 106 1.69e-01 -0.077400 3.75e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 24 5.15e-01 0.076800 7.08e-01
EGFR downregulation 20 5.55e-01 -0.076200 7.41e-01
Mitochondrial translation termination 83 2.31e-01 -0.076200 4.57e-01
IRE1alpha activates chaperones 43 3.88e-01 -0.076100 6.09e-01
Toll Like Receptor 9 (TLR9) Cascade 70 2.72e-01 -0.076000 5.10e-01
Fc epsilon receptor (FCERI) signaling 107 1.76e-01 -0.075800 3.87e-01
Activation of NMDA receptors and postsynaptic events 44 3.85e-01 -0.075800 6.09e-01
Signaling by high-kinase activity BRAF mutants 22 5.39e-01 0.075600 7.31e-01
Transport of bile salts and organic acids, metal ions and amine compounds 34 4.47e-01 0.075300 6.58e-01
Signaling by GPCR 216 5.82e-02 0.075100 1.86e-01
Signaling by FGFR3 26 5.09e-01 0.074900 7.03e-01
TAK1-dependent IKK and NF-kappa-B activation 18 5.83e-01 -0.074800 7.61e-01
G alpha (12/13) signalling events 40 4.14e-01 0.074600 6.25e-01
RHOA GTPase cycle 93 2.18e-01 0.074000 4.46e-01
ADP signalling through P2Y purinoceptor 12 13 6.45e-01 0.073900 8.10e-01
RAF/MAP kinase cascade 159 1.09e-01 -0.073800 2.86e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 35 4.50e-01 -0.073800 6.60e-01
TP53 Regulates Transcription of Cell Death Genes 31 4.78e-01 0.073700 6.84e-01
Signaling by NTRKs 87 2.36e-01 -0.073600 4.59e-01
Transport of small molecules 359 1.78e-02 -0.073300 8.37e-02
Downregulation of ERBB2 signaling 17 6.03e-01 0.072800 7.80e-01
Sphingolipid de novo biosynthesis 22 5.55e-01 -0.072600 7.41e-01
HSF1-dependent transactivation 25 5.31e-01 -0.072500 7.22e-01
Regulation of IFNG signaling 13 6.52e-01 -0.072200 8.16e-01
Costimulation by the CD28 family 44 4.09e-01 -0.071900 6.25e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 31 4.90e-01 0.071600 6.94e-01
G beta:gamma signalling through PI3Kgamma 17 6.10e-01 0.071400 7.82e-01
Biological oxidations 79 2.75e-01 -0.071200 5.12e-01
VLDLR internalisation and degradation 11 6.83e-01 -0.071100 8.36e-01
DNA Damage Recognition in GG-NER 35 4.67e-01 -0.071100 6.74e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 14 6.45e-01 -0.071100 8.10e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 45 4.15e-01 -0.070300 6.25e-01
Adaptive Immune System 481 9.09e-03 -0.070100 5.49e-02
NOD1/2 Signaling Pathway 23 5.62e-01 0.069900 7.45e-01
Synthesis of PA 18 6.08e-01 0.069900 7.81e-01
RHO GTPases activate PKNs 26 5.41e-01 -0.069200 7.32e-01
Suppression of phagosomal maturation 12 6.79e-01 0.069000 8.35e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 23 5.68e-01 0.068700 7.53e-01
Cellular response to heat stress 80 2.89e-01 -0.068700 5.28e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 22 5.79e-01 -0.068300 7.57e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 22 5.79e-01 -0.068300 7.57e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 22 5.79e-01 -0.068300 7.57e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 22 5.79e-01 -0.068300 7.57e-01
Impaired BRCA2 binding to PALB2 22 5.79e-01 -0.068300 7.57e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 35 4.87e-01 0.068000 6.92e-01
Signaling by ERBB4 31 5.13e-01 -0.068000 7.06e-01
Late endosomal microautophagy 23 5.73e-01 -0.067900 7.55e-01
Intraflagellar transport 33 5.01e-01 -0.067600 6.98e-01
Metabolism of lipids 439 1.61e-02 -0.067600 7.81e-02
Signaling by ALK fusions and activated point mutants 46 4.29e-01 -0.067500 6.41e-01
Signaling by ALK in cancer 46 4.29e-01 -0.067500 6.41e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 12 6.87e-01 0.067200 8.36e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 6.22e-01 0.067200 7.93e-01
Degradation of the extracellular matrix 35 4.96e-01 -0.066600 6.97e-01
NR1H2 and NR1H3-mediated signaling 27 5.50e-01 -0.066500 7.41e-01
Deadenylation-dependent mRNA decay 52 4.08e-01 -0.066400 6.25e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 5.18e-01 -0.066100 7.11e-01
Fatty acyl-CoA biosynthesis 26 5.60e-01 -0.066000 7.45e-01
Activation of GABAB receptors 18 6.28e-01 0.066000 7.97e-01
GABA B receptor activation 18 6.28e-01 0.066000 7.97e-01
RIPK1-mediated regulated necrosis 25 5.70e-01 -0.065600 7.53e-01
Regulation of necroptotic cell death 25 5.70e-01 -0.065600 7.53e-01
Glycerophospholipid biosynthesis 74 3.31e-01 -0.065500 5.59e-01
Mitochondrial translation elongation 84 3.06e-01 -0.064700 5.43e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 12 6.99e-01 0.064400 8.42e-01
Trafficking of AMPA receptors 12 6.99e-01 0.064400 8.42e-01
ADORA2B mediated anti-inflammatory cytokines production 33 5.27e-01 -0.063700 7.19e-01
Interleukin-10 signaling 13 6.91e-01 -0.063600 8.37e-01
PIP3 activates AKT signaling 185 1.38e-01 -0.063400 3.34e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 10 7.29e-01 -0.063300 8.50e-01
Intra-Golgi traffic 39 4.95e-01 -0.063100 6.97e-01
Regulation of beta-cell development 16 6.62e-01 -0.063100 8.24e-01
Signaling by Interleukins 265 7.98e-02 -0.062800 2.26e-01
RHO GTPases Activate NADPH Oxidases 14 6.84e-01 0.062800 8.36e-01
Signaling by Receptor Tyrosine Kinases 293 6.60e-02 -0.062800 2.01e-01
Listeria monocytogenes entry into host cells 14 6.88e-01 -0.062000 8.36e-01
Smooth Muscle Contraction 19 6.42e-01 -0.061600 8.09e-01
PTEN Regulation 115 2.57e-01 -0.061300 4.89e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 71 3.73e-01 -0.061200 5.96e-01
Toll Like Receptor 2 (TLR2) Cascade 71 3.73e-01 -0.061200 5.96e-01
Toll Like Receptor TLR1:TLR2 Cascade 71 3.73e-01 -0.061200 5.96e-01
Toll Like Receptor TLR6:TLR2 Cascade 71 3.73e-01 -0.061200 5.96e-01
NGF-stimulated transcription 25 5.98e-01 -0.060900 7.75e-01
Cytosolic sensors of pathogen-associated DNA 53 4.45e-01 -0.060700 6.57e-01
Ion channel transport 80 3.53e-01 -0.060100 5.77e-01
RHOBTB2 GTPase cycle 20 6.42e-01 -0.060000 8.09e-01
Cytokine Signaling in Immune system 427 3.49e-02 -0.060000 1.32e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 11 7.31e-01 -0.059800 8.52e-01
TCR signaling 87 3.45e-01 -0.058600 5.68e-01
Metalloprotease DUBs 17 6.76e-01 -0.058500 8.34e-01
The NLRP3 inflammasome 12 7.28e-01 0.058000 8.50e-01
Interleukin-2 family signaling 28 5.96e-01 0.057900 7.73e-01
Spry regulation of FGF signaling 15 6.99e-01 0.057700 8.42e-01
Axon guidance 300 8.79e-02 -0.057600 2.45e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 29 5.93e-01 -0.057300 7.71e-01
Myogenesis 13 7.21e-01 0.057300 8.47e-01
activated TAK1 mediates p38 MAPK activation 13 7.22e-01 0.057000 8.47e-01
Attenuation phase 19 6.67e-01 -0.057000 8.27e-01
G alpha (z) signalling events 25 6.23e-01 0.056900 7.94e-01
RIP-mediated NFkB activation via ZBP1 14 7.13e-01 -0.056800 8.45e-01
Regulation of RUNX1 Expression and Activity 17 6.87e-01 0.056500 8.36e-01
Gap junction trafficking and regulation 11 7.46e-01 -0.056400 8.59e-01
Nuclear signaling by ERBB4 16 6.97e-01 -0.056300 8.42e-01
Nuclear Envelope (NE) Reassembly 60 4.51e-01 -0.056300 6.60e-01
RMTs methylate histone arginines 25 6.28e-01 -0.056100 7.97e-01
Platelet homeostasis 49 4.99e-01 -0.055900 6.97e-01
Nervous system development 313 9.48e-02 -0.055200 2.60e-01
RND1 GTPase cycle 29 6.07e-01 -0.055200 7.81e-01
FCERI mediated Ca+2 mobilization 23 6.49e-01 0.054800 8.13e-01
Signaling by NOTCH1 51 5.00e-01 -0.054600 6.97e-01
Bile acid and bile salt metabolism 15 7.14e-01 -0.054600 8.46e-01
Collagen formation 28 6.19e-01 0.054300 7.91e-01
Nuclear Envelope Breakdown 49 5.11e-01 -0.054300 7.04e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 14 7.25e-01 -0.054300 8.49e-01
DARPP-32 events 21 6.68e-01 -0.054000 8.28e-01
ROS and RNS production in phagocytes 23 6.54e-01 -0.054000 8.17e-01
Innate Immune System 620 2.35e-02 -0.053900 9.97e-02
Regulation of PTEN gene transcription 48 5.18e-01 0.053900 7.11e-01
Cell recruitment (pro-inflammatory response) 15 7.18e-01 0.053900 8.47e-01
Purinergic signaling in leishmaniasis infection 15 7.18e-01 0.053900 8.47e-01
Protein-protein interactions at synapses 33 5.97e-01 0.053200 7.74e-01
Regulation of MECP2 expression and activity 23 6.59e-01 0.053100 8.21e-01
Dopamine Neurotransmitter Release Cycle 12 7.51e-01 0.052900 8.63e-01
Regulation of BACH1 activity 11 7.62e-01 -0.052800 8.66e-01
Transcriptional regulation of granulopoiesis 25 6.54e-01 0.051800 8.17e-01
Translesion synthesis by POLK 15 7.29e-01 -0.051700 8.50e-01
Signaling by FGFR1 28 6.38e-01 0.051400 8.08e-01
Retinoid metabolism and transport 11 7.69e-01 -0.051200 8.66e-01
Extracellular matrix organization 93 3.96e-01 0.051000 6.14e-01
Mitochondrial calcium ion transport 19 7.02e-01 -0.050800 8.42e-01
Negative regulation of FGFR1 signaling 18 7.10e-01 0.050700 8.44e-01
Negative regulation of FGFR2 signaling 18 7.10e-01 0.050700 8.44e-01
Negative regulation of FGFR3 signaling 18 7.10e-01 0.050700 8.44e-01
Negative regulation of FGFR4 signaling 18 7.10e-01 0.050700 8.44e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 7.11e-01 0.050400 8.44e-01
Rab regulation of trafficking 94 4.00e-01 -0.050300 6.17e-01
SUMOylation of transcription factors 13 7.54e-01 -0.050200 8.65e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 7.36e-01 0.050200 8.53e-01
VEGFA-VEGFR2 Pathway 71 4.67e-01 -0.050000 6.74e-01
Josephin domain DUBs 11 7.76e-01 -0.049500 8.71e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 19 7.09e-01 -0.049500 8.44e-01
Transcriptional Regulation by E2F6 29 6.45e-01 -0.049400 8.10e-01
Transcriptional regulation of white adipocyte differentiation 56 5.23e-01 -0.049400 7.15e-01
Amyloid fiber formation 27 6.58e-01 0.049200 8.20e-01
mRNA decay by 3’ to 5’ exoribonuclease 14 7.50e-01 0.049200 8.63e-01
RHOB GTPase cycle 44 5.75e-01 -0.048900 7.56e-01
Aquaporin-mediated transport 25 6.73e-01 0.048800 8.32e-01
Signaling by BRAF and RAF1 fusions 42 5.85e-01 -0.048800 7.62e-01
SUMOylation of chromatin organization proteins 49 5.55e-01 -0.048800 7.41e-01
A tetrasaccharide linker sequence is required for GAG synthesis 10 7.90e-01 -0.048700 8.78e-01
Formation of the beta-catenin:TCF transactivating complex 25 6.74e-01 -0.048600 8.33e-01
NRAGE signals death through JNK 30 6.47e-01 -0.048300 8.12e-01
HDMs demethylate histones 15 7.46e-01 -0.048200 8.59e-01
Signaling by RAF1 mutants 25 6.80e-01 0.047700 8.35e-01
Metal ion SLC transporters 16 7.42e-01 0.047500 8.56e-01
Developmental Biology 468 8.25e-02 -0.047300 2.31e-01
Regulation of signaling by CBL 14 7.63e-01 -0.046500 8.66e-01
Cytochrome P450 - arranged by substrate type 14 7.65e-01 0.046100 8.66e-01
Signaling by VEGF 73 5.02e-01 -0.045500 6.98e-01
G-protein beta:gamma signalling 21 7.21e-01 0.045000 8.47e-01
E2F mediated regulation of DNA replication 19 7.36e-01 0.044800 8.53e-01
Deadenylation of mRNA 23 7.11e-01 -0.044700 8.44e-01
NOTCH3 Intracellular Domain Regulates Transcription 15 7.65e-01 0.044500 8.66e-01
Netrin-1 signaling 25 7.01e-01 0.044400 8.42e-01
L1CAM interactions 41 6.24e-01 -0.044300 7.94e-01
STING mediated induction of host immune responses 10 8.09e-01 0.044100 8.88e-01
Post NMDA receptor activation events 38 6.39e-01 -0.044000 8.08e-01
FLT3 Signaling 32 6.67e-01 0.043900 8.27e-01
Caspase activation via extrinsic apoptotic signalling pathway 15 7.68e-01 0.043900 8.66e-01
RUNX3 regulates p14-ARF 10 8.12e-01 -0.043500 8.88e-01
Signal Transduction 1356 1.01e-02 -0.042800 5.82e-02
O-linked glycosylation of mucins 26 7.06e-01 0.042700 8.44e-01
Extra-nuclear estrogen signaling 49 6.06e-01 -0.042700 7.81e-01
Signaling by SCF-KIT 32 6.79e-01 -0.042300 8.35e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 16 7.70e-01 0.042300 8.66e-01
Carboxyterminal post-translational modifications of tubulin 24 7.20e-01 0.042300 8.47e-01
EPHB-mediated forward signaling 25 7.16e-01 -0.042100 8.46e-01
Phosphorylation of the APC/C 18 7.58e-01 0.041900 8.66e-01
Synthesis of PC 22 7.34e-01 -0.041800 8.53e-01
GABA receptor activation 19 7.54e-01 0.041500 8.65e-01
COPII-mediated vesicle transport 51 6.11e-01 -0.041200 7.82e-01
Post-translational protein phosphorylation 34 6.79e-01 0.041000 8.35e-01
Nuclear events stimulated by ALK signaling in cancer 14 7.91e-01 0.040900 8.78e-01
Termination of O-glycan biosynthesis 10 8.23e-01 0.040800 8.91e-01
Signaling by FGFR4 25 7.27e-01 0.040400 8.50e-01
Neuronal System 139 4.13e-01 0.040300 6.25e-01
Regulation of TP53 Activity through Methylation 17 7.74e-01 0.040200 8.70e-01
Apoptotic execution phase 33 6.92e-01 0.039900 8.37e-01
RHO GTPase cycle 294 2.42e-01 0.039900 4.66e-01
Growth hormone receptor signaling 17 7.78e-01 0.039500 8.72e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 14 7.99e-01 0.039300 8.83e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 8.07e-01 -0.039100 8.88e-01
Signaling by Non-Receptor Tyrosine Kinases 36 6.86e-01 -0.039000 8.36e-01
Signaling by PTK6 36 6.86e-01 -0.039000 8.36e-01
tRNA modification in the nucleus and cytosol 34 6.97e-01 -0.038600 8.42e-01
Glucagon-type ligand receptors 14 8.04e-01 0.038200 8.87e-01
Neurotransmitter release cycle 20 7.67e-01 0.038200 8.66e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 14 8.05e-01 0.038100 8.87e-01
Chromatin modifying enzymes 158 4.13e-01 -0.037900 6.25e-01
Chromatin organization 158 4.13e-01 -0.037900 6.25e-01
Insulin receptor signalling cascade 26 7.39e-01 0.037800 8.54e-01
Gap junction trafficking 10 8.38e-01 -0.037400 8.99e-01
Immune System 1156 3.64e-02 -0.037400 1.36e-01
Syndecan interactions 10 8.38e-01 0.037300 8.99e-01
Other interleukin signaling 15 8.05e-01 0.036800 8.87e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 15 8.07e-01 -0.036500 8.88e-01
Calnexin/calreticulin cycle 23 7.63e-01 0.036400 8.66e-01
RHOBTB GTPase Cycle 29 7.35e-01 -0.036300 8.53e-01
Amino acids regulate mTORC1 42 6.89e-01 -0.035700 8.37e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 20 7.83e-01 -0.035500 8.77e-01
The role of Nef in HIV-1 replication and disease pathogenesis 19 7.89e-01 0.035500 8.78e-01
Neutrophil degranulation 307 2.89e-01 -0.035400 5.28e-01
Integration of energy metabolism 60 6.38e-01 -0.035200 8.08e-01
Mitotic Prophase 75 6.07e-01 -0.034400 7.81e-01
RHOQ GTPase cycle 39 7.11e-01 0.034200 8.44e-01
Signaling by Insulin receptor 42 7.03e-01 -0.034100 8.42e-01
CD209 (DC-SIGN) signaling 15 8.21e-01 -0.033800 8.90e-01
Effects of PIP2 hydrolysis 19 7.99e-01 0.033800 8.83e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 16 8.17e-01 -0.033500 8.90e-01
Visual phototransduction 34 7.36e-01 0.033400 8.53e-01
RHOC GTPase cycle 49 6.86e-01 0.033400 8.36e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 38 7.23e-01 0.033200 8.48e-01
Sensory processing of sound 27 7.66e-01 0.033000 8.66e-01
Sensory processing of sound by inner hair cells of the cochlea 27 7.66e-01 0.033000 8.66e-01
APC/C:Cdc20 mediated degradation of Cyclin B 22 7.89e-01 0.032900 8.78e-01
Oxidative Stress Induced Senescence 55 6.76e-01 0.032500 8.34e-01
CTLA4 inhibitory signaling 16 8.22e-01 -0.032500 8.90e-01
FOXO-mediated transcription of cell cycle genes 13 8.39e-01 -0.032500 8.99e-01
PI Metabolism 60 6.64e-01 0.032400 8.26e-01
Nicotinamide salvaging 11 8.53e-01 0.032300 9.06e-01
Budding and maturation of HIV virion 24 7.85e-01 -0.032200 8.77e-01
Glycogen storage diseases 10 8.62e-01 -0.031800 9.13e-01
RHOU GTPase cycle 32 7.58e-01 -0.031500 8.66e-01
Glucagon signaling in metabolic regulation 18 8.18e-01 -0.031300 8.90e-01
Cell-Cell communication 48 7.08e-01 0.031200 8.44e-01
Protein methylation 14 8.40e-01 -0.031200 8.99e-01
Cargo concentration in the ER 20 8.13e-01 0.030600 8.88e-01
EPH-Ephrin signaling 55 7.00e-01 -0.030000 8.42e-01
Nicotinate metabolism 19 8.21e-01 0.029900 8.90e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 8.22e-01 0.029800 8.90e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 8.22e-01 0.029800 8.90e-01
Regulation of actin dynamics for phagocytic cup formation 44 7.34e-01 0.029600 8.53e-01
Signalling to RAS 12 8.59e-01 -0.029600 9.11e-01
Deactivation of the beta-catenin transactivating complex 28 7.88e-01 -0.029300 8.78e-01
Inflammasomes 16 8.40e-01 0.029200 8.99e-01
DCC mediated attractive signaling 11 8.69e-01 -0.028600 9.18e-01
Signalling to ERKs 25 8.05e-01 0.028500 8.87e-01
MAPK targets/ Nuclear events mediated by MAP kinases 23 8.13e-01 -0.028500 8.88e-01
Lysosome Vesicle Biogenesis 24 8.10e-01 0.028300 8.88e-01
Amino acid transport across the plasma membrane 16 8.45e-01 -0.028200 9.02e-01
Uptake and actions of bacterial toxins 18 8.38e-01 -0.027900 8.99e-01
Synthesis of PIPs at the plasma membrane 36 7.74e-01 0.027700 8.70e-01
RHOBTB1 GTPase cycle 18 8.42e-01 0.027100 9.01e-01
Regulation of insulin secretion 40 7.68e-01 0.027000 8.66e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 8.72e-01 -0.026800 9.19e-01
GPER1 signaling 25 8.18e-01 0.026600 8.90e-01
Cardiac conduction 43 7.66e-01 0.026300 8.66e-01
Platelet activation, signaling and aggregation 132 6.03e-01 -0.026300 7.80e-01
FCGR3A-mediated phagocytosis 42 7.69e-01 0.026200 8.66e-01
Leishmania phagocytosis 42 7.69e-01 0.026200 8.66e-01
Parasite infection 42 7.69e-01 0.026200 8.66e-01
KSRP (KHSRP) binds and destabilizes mRNA 15 8.61e-01 -0.026000 9.13e-01
Neurexins and neuroligins 21 8.37e-01 0.025900 8.99e-01
Pre-NOTCH Expression and Processing 46 7.62e-01 -0.025800 8.66e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 8.17e-01 0.025700 8.90e-01
Pexophagy 11 8.83e-01 0.025600 9.27e-01
Assembly of collagen fibrils and other multimeric structures 14 8.70e-01 0.025300 9.18e-01
Interleukin-17 signaling 52 7.59e-01 0.024600 8.66e-01
TGF-beta receptor signaling activates SMADs 39 7.92e-01 0.024500 8.78e-01
Synthesis of PIPs at the Golgi membrane 12 8.84e-01 0.024400 9.27e-01
Transmission across Chemical Synapses 101 6.73e-01 0.024400 8.32e-01
Clathrin-mediated endocytosis 89 6.92e-01 -0.024400 8.37e-01
RAB GEFs exchange GTP for GDP on RABs 64 7.39e-01 0.024100 8.54e-01
Muscle contraction 67 7.40e-01 -0.023500 8.54e-01
PPARA activates gene expression 82 7.15e-01 -0.023300 8.46e-01
APC-Cdc20 mediated degradation of Nek2A 24 8.45e-01 0.023100 9.02e-01
Basigin interactions 14 8.81e-01 0.023100 9.27e-01
GPVI-mediated activation cascade 23 8.49e-01 -0.023000 9.04e-01
G alpha (s) signalling events 48 7.85e-01 0.022800 8.77e-01
Cellular Senescence 106 6.86e-01 -0.022800 8.36e-01
VEGFR2 mediated vascular permeability 21 8.58e-01 -0.022500 9.11e-01
RHOJ GTPase cycle 37 8.14e-01 0.022400 8.88e-01
Leishmania infection 112 6.83e-01 -0.022400 8.36e-01
RAB geranylgeranylation 40 8.09e-01 0.022100 8.88e-01
Synthesis of PIPs at the early endosome membrane 12 8.95e-01 -0.022000 9.36e-01
SLC-mediated transmembrane transport 105 6.98e-01 -0.022000 8.42e-01
Interleukin receptor SHC signaling 15 8.83e-01 -0.021900 9.27e-01
rRNA modification in the nucleus and cytosol 49 7.91e-01 -0.021900 8.78e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 29 8.40e-01 -0.021700 8.99e-01
Signaling by RAS mutants 29 8.40e-01 -0.021700 8.99e-01
Signaling by moderate kinase activity BRAF mutants 29 8.40e-01 -0.021700 8.99e-01
Signaling downstream of RAS mutants 29 8.40e-01 -0.021700 8.99e-01
Pre-NOTCH Transcription and Translation 31 8.39e-01 -0.021100 8.99e-01
Signal amplification 20 8.73e-01 -0.020700 9.19e-01
Opioid Signalling 58 7.89e-01 -0.020400 8.78e-01
Signaling by Erythropoietin 19 8.79e-01 0.020100 9.25e-01
RND3 GTPase cycle 29 8.52e-01 0.020100 9.06e-01
Nonhomologous End-Joining (NHEJ) 29 8.52e-01 -0.020100 9.06e-01
Maturation of nucleoprotein 11 9.09e-01 -0.019900 9.44e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 449 4.74e-01 -0.019900 6.81e-01
Processing of SMDT1 13 9.04e-01 0.019200 9.42e-01
Regulation of FZD by ubiquitination 12 9.08e-01 0.019200 9.44e-01
Signaling by Rho GTPases 437 5.03e-01 -0.018800 6.99e-01
Phospholipid metabolism 133 7.18e-01 -0.018100 8.47e-01
Metabolic disorders of biological oxidation enzymes 14 9.07e-01 -0.018000 9.44e-01
Sensory processing of sound by outer hair cells of the cochlea 18 8.95e-01 -0.017900 9.36e-01
Class B/2 (Secretin family receptors) 29 8.69e-01 -0.017700 9.18e-01
Ephrin signaling 12 9.15e-01 -0.017700 9.49e-01
Signaling by NOTCH3 30 8.67e-01 -0.017700 9.17e-01
Plasma lipoprotein remodeling 11 9.20e-01 0.017600 9.50e-01
Transcriptional regulation by RUNX1 137 7.24e-01 0.017500 8.48e-01
Hemostasis 304 6.05e-01 -0.017300 7.81e-01
Regulation of lipid metabolism by PPARalpha 84 7.89e-01 -0.016900 8.78e-01
Signaling by TGFB family members 85 7.93e-01 -0.016500 8.78e-01
DAP12 signaling 19 9.01e-01 -0.016400 9.40e-01
mTORC1-mediated signalling 21 8.98e-01 0.016200 9.38e-01
Signaling by TGF-beta Receptor Complex 72 8.13e-01 -0.016100 8.88e-01
NOTCH4 Intracellular Domain Regulates Transcription 14 9.18e-01 -0.015800 9.50e-01
Activated NOTCH1 Transmits Signal to the Nucleus 19 9.09e-01 -0.015100 9.44e-01
Negative regulation of the PI3K/AKT network 56 8.48e-01 -0.014800 9.04e-01
Caspase activation via Death Receptors in the presence of ligand 10 9.36e-01 0.014700 9.60e-01
Gastrin-CREB signalling pathway via PKC and MAPK 11 9.35e-01 -0.014200 9.60e-01
Ca2+ pathway 40 8.85e-01 -0.013300 9.27e-01
Transcriptional Regulation by MECP2 31 8.99e-01 0.013200 9.38e-01
Regulation of KIT signaling 10 9.44e-01 0.012900 9.65e-01
Apoptotic factor-mediated response 16 9.40e-01 -0.010800 9.64e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 29 9.21e-01 -0.010700 9.50e-01
Integrin cell surface interactions 25 9.27e-01 0.010600 9.55e-01
Regulation of TP53 Degradation 33 9.17e-01 -0.010500 9.50e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 14 9.47e-01 -0.010200 9.67e-01
Signaling by ERBB2 33 9.20e-01 -0.010200 9.50e-01
Cargo recognition for clathrin-mediated endocytosis 63 8.91e-01 0.009980 9.33e-01
Interconversion of nucleotide di- and triphosphates 25 9.35e-01 -0.009440 9.60e-01
Senescence-Associated Secretory Phenotype (SASP) 42 9.18e-01 0.009220 9.50e-01
Cytosolic sulfonation of small molecules 10 9.60e-01 -0.009150 9.75e-01
SUMOylation of transcription cofactors 35 9.27e-01 0.008900 9.55e-01
Telomere Extension By Telomerase 20 9.45e-01 0.008840 9.65e-01
Interleukin-37 signaling 17 9.51e-01 -0.008580 9.70e-01
Chondroitin sulfate/dermatan sulfate metabolism 27 9.43e-01 -0.007970 9.65e-01
Negative regulation of MET activity 16 9.58e-01 -0.007670 9.73e-01
Vasopressin regulates renal water homeostasis via Aquaporins 23 9.53e-01 -0.007070 9.70e-01
Regulation of TP53 Expression and Degradation 34 9.43e-01 -0.007060 9.65e-01
Sensory Perception 68 9.28e-01 0.006330 9.55e-01
Neurotransmitter receptors and postsynaptic signal transmission 77 9.35e-01 -0.005360 9.60e-01
Signaling by ERBB2 in Cancer 13 9.74e-01 0.005310 9.85e-01
HDR through MMEJ (alt-NHEJ) 11 9.76e-01 -0.005160 9.87e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 27 9.63e-01 -0.005130 9.77e-01
MAP kinase activation 49 9.52e-01 -0.004940 9.70e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 50 9.55e-01 0.004600 9.71e-01
Oncogene Induced Senescence 30 9.68e-01 0.004180 9.81e-01
Stimuli-sensing channels 39 9.68e-01 0.003760 9.81e-01
Phase I - Functionalization of compounds 30 9.79e-01 0.002730 9.89e-01
Constitutive Signaling by Aberrant PI3K in Cancer 28 9.82e-01 0.002400 9.92e-01
Downregulation of TGF-beta receptor signaling 26 9.86e-01 -0.002050 9.93e-01
Fanconi Anemia Pathway 31 9.86e-01 0.001860 9.93e-01
Activation of the pre-replicative complex 30 9.93e-01 -0.000921 9.99e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 39 9.92e-01 0.000895 9.99e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 23 9.95e-01 -0.000689 9.99e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 9.97e-01 0.000651 9.99e-01
Signaling by BMP 15 9.97e-01 0.000611 9.99e-01
Class I peroxisomal membrane protein import 19 9.99e-01 0.000233 9.99e-01
Signaling by ERBB2 TMD/JMD mutants 10 9.99e-01 -0.000158 9.99e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 9.99e-01 -0.000143 9.99e-01
RHO GTPases Activate WASPs and WAVEs 29 9.99e-01 -0.000095 9.99e-01


Detailed Gene set reports



Signaling by FGFR2 IIIa TM

Signaling by FGFR2 IIIa TM
971
set Signaling by FGFR2 IIIa TM
setSize 15
pANOVA 0.000206
s.dist -0.553
p.adjustANOVA 0.00591



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
NCBP2 -9664.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
GTF2F2 -6749.0
POLR2E -6287.0
POLR2G -4807.0
POLR2K 759.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
NCBP2 -9664.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
GTF2F2 -6749.0
POLR2E -6287.0
POLR2G -4807.0
POLR2K 759.0


Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs
731
set Processing of Intronless Pre-mRNAs
setSize 15
pANOVA 0.000923
s.dist -0.494
p.adjustANOVA 0.0132



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10862.5
PAPOLA -9722.0
NCBP2 -9664.0
CLP1 -9567.0
CPSF4 -9543.5
CPSF2 -9271.5
SYMPK -9204.0
FIP1L1 -8873.0
CPSF1 -7981.0
CPSF3 -7711.5
NUDT21 -7427.5
WDR33 -7350.0
CSTF1 -6137.5
CPSF6 -3033.0
PABPN1 -1407.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10862.5
PAPOLA -9722.0
NCBP2 -9664.0
CLP1 -9567.0
CPSF4 -9543.5
CPSF2 -9271.5
SYMPK -9204.0
FIP1L1 -8873.0
CPSF1 -7981.0
CPSF3 -7711.5
NUDT21 -7427.5
WDR33 -7350.0
CSTF1 -6137.5
CPSF6 -3033.0
PABPN1 -1407.0


FGFR2 mutant receptor activation

FGFR2 mutant receptor activation
309
set FGFR2 mutant receptor activation
setSize 17
pANOVA 0.000569
s.dist -0.483
p.adjustANOVA 0.0114



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
NCBP2 -9664.0
FGF9 -9202.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
GTF2F2 -6749.0
POLR2E -6287.0
POLR2G -4807.0
FGF8 0.5
POLR2K 759.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
NCBP2 -9664.0
FGF9 -9202.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
GTF2F2 -6749.0
POLR2E -6287.0
POLR2G -4807.0
FGF8 0.5
POLR2K 759.0


Endosomal/Vacuolar pathway

Endosomal/Vacuolar pathway
287
set Endosomal/Vacuolar pathway
setSize 10
pANOVA 0.00962
s.dist -0.473
p.adjustANOVA 0.0567



Top enriched genes

Top 20 genes
GeneID Gene Rank
HLA-C -10864
HLA-E -10859
HLA-B -10847
HLA-H -10829
HLA-F -10526
HLA-A -7860
LNPEP -7825
CTSL -5506
CTSV -2739
B2M 614

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HLA-C -10864
HLA-E -10859
HLA-B -10847
HLA-H -10829
HLA-F -10526
HLA-A -7860
LNPEP -7825
CTSL -5506
CTSV -2739
B2M 614


SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
908
set SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize 10
pANOVA 0.0116
s.dist -0.461
p.adjustANOVA 0.0622



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10862.5
SNRPG -9891.0
NCBP2 -9664.0
LSM10 -9351.0
LSM11 -9063.0
SNRPD3 -8183.0
SLBP -7597.0
ZNF473 -6427.5
SNRPE -3828.0
SNRPB -1652.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10862.5
SNRPG -9891.0
NCBP2 -9664.0
LSM10 -9351.0
LSM11 -9063.0
SNRPD3 -8183.0
SLBP -7597.0
ZNF473 -6427.5
SNRPE -3828.0
SNRPB -1652.0


Processing of Capped Intronless Pre-mRNA

Processing of Capped Intronless Pre-mRNA
729
set Processing of Capped Intronless Pre-mRNA
setSize 23
pANOVA 0.000221
s.dist -0.445
p.adjustANOVA 0.00617



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10862.5
SNRPG -9891.0
PAPOLA -9722.0
NCBP2 -9664.0
CLP1 -9567.0
CPSF4 -9543.5
LSM10 -9351.0
CPSF2 -9271.5
SYMPK -9204.0
LSM11 -9063.0
FIP1L1 -8873.0
SNRPD3 -8183.0
CPSF1 -7981.0
CPSF3 -7711.5
SLBP -7597.0
NUDT21 -7427.5
WDR33 -7350.0
ZNF473 -6427.5
CSTF1 -6137.5
SNRPE -3828.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10862.5
SNRPG -9891.0
PAPOLA -9722.0
NCBP2 -9664.0
CLP1 -9567.0
CPSF4 -9543.5
LSM10 -9351.0
CPSF2 -9271.5
SYMPK -9204.0
LSM11 -9063.0
FIP1L1 -8873.0
SNRPD3 -8183.0
CPSF1 -7981.0
CPSF3 -7711.5
SLBP -7597.0
NUDT21 -7427.5
WDR33 -7350.0
ZNF473 -6427.5
CSTF1 -6137.5
SNRPE -3828.0
CPSF6 -3033.0
SNRPB -1652.0
PABPN1 -1407.0


Signaling by FGFR2 in disease

Signaling by FGFR2 in disease
972
set Signaling by FGFR2 in disease
setSize 24
pANOVA 0.000391
s.dist -0.418
p.adjustANOVA 0.00941



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
GRB2 -10484.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
NCBP2 -9664.0
FGF9 -9202.0
PIK3R1 -9176.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
GTF2F2 -6749.0
POLR2E -6287.0
PLCG1 -6172.0
PIK3CA -6171.0
FRS2 -5177.0
HRAS -4847.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
GRB2 -10484.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
NCBP2 -9664.0
FGF9 -9202.0
PIK3R1 -9176.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
GTF2F2 -6749.0
POLR2E -6287.0
PLCG1 -6172.0
PIK3CA -6171.0
FRS2 -5177.0
HRAS -4847.0
POLR2G -4807.0
KRAS -3124.0
FGF8 0.5
POLR2K 759.0


FGFR2 alternative splicing

FGFR2 alternative splicing
308
set FGFR2 alternative splicing
setSize 22
pANOVA 0.000736
s.dist -0.416
p.adjustANOVA 0.0127



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
HNRNPF -10748.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
NCBP2 -9664.0
TIAL1 -9318.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
GTF2F2 -6749.0
POLR2E -6287.0
PTBP1 -5480.0
TIA1 -4946.0
ESRP2 -4837.0
POLR2G -4807.0
HNRNPH1 -2605.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
HNRNPF -10748.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
NCBP2 -9664.0
TIAL1 -9318.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
GTF2F2 -6749.0
POLR2E -6287.0
PTBP1 -5480.0
TIA1 -4946.0
ESRP2 -4837.0
POLR2G -4807.0
HNRNPH1 -2605.0
HNRNPM -1327.0
POLR2K 759.0


Generation of second messenger molecules

Generation of second messenger molecules
374
set Generation of second messenger molecules
setSize 15
pANOVA 0.00534
s.dist 0.415
p.adjustANOVA 0.0406



Top enriched genes

Top 20 genes
GeneID Gene Rank
LCP2 742.0
EVL 590.0
PAK2 0.5
ITK 0.5
GRAP2 -562.0
ZAP70 -1145.0
LCK -1212.0
PAK1 -1637.0
CD3E -2347.0
CD4 -2512.0
VASP -2882.0
CD247 -3140.0
PLCG1 -6172.0
NCK1 -6319.0
PLCG2 -9345.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LCP2 742.0
EVL 590.0
PAK2 0.5
ITK 0.5
GRAP2 -562.0
ZAP70 -1145.0
LCK -1212.0
PAK1 -1637.0
CD3E -2347.0
CD4 -2512.0
VASP -2882.0
CD247 -3140.0
PLCG1 -6172.0
NCK1 -6319.0
PLCG2 -9345.0


Sema4D induced cell migration and growth-cone collapse

Sema4D induced cell migration and growth-cone collapse
933
set Sema4D induced cell migration and growth-cone collapse
setSize 12
pANOVA 0.0133
s.dist 0.413
p.adjustANOVA 0.0685



Top enriched genes

Top 20 genes
GeneID Gene Rank
SEMA4D 827.0
MYH10 658.0
ARHGEF12 0.5
LIMK1 0.5
ERBB2 -1473.0
MYL6 -1879.0
ROCK1 -2506.0
MYH9 -3422.0
RHOB -4051.0
RHOA -4615.5
LIMK2 -5608.0
RND1 -6869.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SEMA4D 827.0
MYH10 658.0
ARHGEF12 0.5
LIMK1 0.5
ERBB2 -1473.0
MYL6 -1879.0
ROCK1 -2506.0
MYH9 -3422.0
RHOB -4051.0
RHOA -4615.5
LIMK2 -5608.0
RND1 -6869.0


Role of phospholipids in phagocytosis

Role of phospholipids in phagocytosis
894
set Role of phospholipids in phagocytosis
setSize 16
pANOVA 0.00564
s.dist -0.4
p.adjustANOVA 0.0418



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITPR2 -10842.0
ITPR1 -10668.0
ITPR3 -10210.0
PLA2G6 -10180.0
PLD3 -9459.5
PLCG2 -9345.0
PIK3R1 -9176.0
PIK3R2 -8576.0
PRKCD -8312.0
PLD1 -7596.0
PLCG1 -6172.0
PIK3CA -6171.0
AHCYL1 -3575.0
CD247 -3140.0
SYK -3132.0
PRKCE 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITPR2 -10842.0
ITPR1 -10668.0
ITPR3 -10210.0
PLA2G6 -10180.0
PLD3 -9459.5
PLCG2 -9345.0
PIK3R1 -9176.0
PIK3R2 -8576.0
PRKCD -8312.0
PLD1 -7596.0
PLCG1 -6172.0
PIK3CA -6171.0
AHCYL1 -3575.0
CD247 -3140.0
SYK -3132.0
PRKCE 0.5


TNFR1-induced proapoptotic signaling

TNFR1-induced proapoptotic signaling
1064
set TNFR1-induced proapoptotic signaling
setSize 12
pANOVA 0.017
s.dist -0.398
p.adjustANOVA 0.0813



Top enriched genes

Top 20 genes
GeneID Gene Rank
FADD -9833.0
TRADD -9607.5
USP21 -9125.0
TNFAIP3 -8862.0
CYLD -8401.0
USP4 -8383.0
TNF -7558.0
USP2 -7457.0
TNFRSF1A -6764.0
OTUD7B -6170.0
TRAF2 -5920.0
CASP8 783.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FADD -9833.0
TRADD -9607.5
USP21 -9125.0
TNFAIP3 -8862.0
CYLD -8401.0
USP4 -8383.0
TNF -7558.0
USP2 -7457.0
TNFRSF1A -6764.0
OTUD7B -6170.0
TRAF2 -5920.0
CASP8 783.0


TNFs bind their physiological receptors

TNFs bind their physiological receptors
1066
set TNFs bind their physiological receptors
setSize 10
pANOVA 0.031
s.dist 0.394
p.adjustANOVA 0.122



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNFSF13 792.5
TNFRSF25 747.0
TNFSF14 0.5
CD27 -876.0
TNFRSF1B -1422.0
EDARADD -1501.0
LTA -4033.0
TNFSF9 -5137.0
TNFRSF1A -6764.0
TNFSF13B -7046.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNFSF13 792.5
TNFRSF25 747.0
TNFSF14 0.5
CD27 -876.0
TNFRSF1B -1422.0
EDARADD -1501.0
LTA -4033.0
TNFSF9 -5137.0
TNFRSF1A -6764.0
TNFSF13B -7046.0


Inhibition of DNA recombination at telomere

Inhibition of DNA recombination at telomere
448
set Inhibition of DNA recombination at telomere
setSize 18
pANOVA 0.00415
s.dist -0.39
p.adjustANOVA 0.0345



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
TERF2IP -10201.5
POLR2A -10101.0
POLR2B -9678.0
POLR2C -8847.0
POLR2H -8272.0
ACD -8085.5
POLR2I -8056.5
H2AFX -7725.0
POLR2E -6287.0
DAXX -5548.0
TINF2 -5025.0
POLR2G -4807.0
TERF1 -4194.0
TERF2 -2513.0
POLR2K 759.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
TERF2IP -10201.5
POLR2A -10101.0
POLR2B -9678.0
POLR2C -8847.0
POLR2H -8272.0
ACD -8085.5
POLR2I -8056.5
H2AFX -7725.0
POLR2E -6287.0
DAXX -5548.0
TINF2 -5025.0
POLR2G -4807.0
TERF1 -4194.0
TERF2 -2513.0
POLR2K 759.0


Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Antigen Presentation: Folding, assembly and peptide loading of class I MHC
51
set Antigen Presentation: Folding, assembly and peptide loading of class I MHC
setSize 26
pANOVA 0.000606
s.dist -0.388
p.adjustANOVA 0.0119



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAP1 -10878.0
HLA-C -10864.0
HLA-E -10859.0
HLA-B -10847.0
HLA-H -10829.0
TAPBP -10817.0
HLA-F -10526.0
SEC24A -10355.0
TAP2 -10109.0
SEC23A -9815.0
SAR1B -9588.0
SEC31A -9320.0
SEC24B -9314.0
SEC13 -9014.0
ERAP1 -8751.0
CALR -8492.0
BECN1 -8223.0
HLA-A -7860.0
PDIA3 -6700.5
CANX -4313.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAP1 -10878.0
HLA-C -10864.0
HLA-E -10859.0
HLA-B -10847.0
HLA-H -10829.0
TAPBP -10817.0
HLA-F -10526.0
SEC24A -10355.0
TAP2 -10109.0
SEC23A -9815.0
SAR1B -9588.0
SEC31A -9320.0
SEC24B -9314.0
SEC13 -9014.0
ERAP1 -8751.0
CALR -8492.0
BECN1 -8223.0
HLA-A -7860.0
PDIA3 -6700.5
CANX -4313.0
SEC24C -896.0
PIK3R4 -685.0
ATG14 0.5
ERAP2 0.5
B2M 614.0
SEC24D 839.0


Abortive elongation of HIV-1 transcript in the absence of Tat

Abortive elongation of HIV-1 transcript in the absence of Tat
24
set Abortive elongation of HIV-1 transcript in the absence of Tat
setSize 22
pANOVA 0.00235
s.dist -0.375
p.adjustANOVA 0.0267



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
SUPT4H1 -10212.0
POLR2A -10101.0
CTDP1 -9804.0
POLR2B -9678.0
NCBP2 -9664.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
SUPT5H -7677.0
GTF2F2 -6749.0
POLR2E -6287.0
POLR2G -4807.0
NELFB -3334.0
NELFA -2813.0
NELFCD 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
SUPT4H1 -10212.0
POLR2A -10101.0
CTDP1 -9804.0
POLR2B -9678.0
NCBP2 -9664.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
SUPT5H -7677.0
GTF2F2 -6749.0
POLR2E -6287.0
POLR2G -4807.0
NELFB -3334.0
NELFA -2813.0
NELFCD 0.5
NELFE 0.5
POLR2K 759.0


Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
143
set Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
setSize 13
pANOVA 0.0202
s.dist -0.372
p.adjustANOVA 0.0911



Top enriched genes

Top 20 genes
GeneID Gene Rank
YWHAE -10611.0
CDC25C -10299.0
CHEK2 -9675.5
WEE1 -9251.0
YWHAG -8883.0
CHEK1 -8742.0
CCNB1 -8105.0
YWHAZ -6950.0
YWHAQ -6859.0
YWHAH -6166.0
CDK1 -5335.0
YWHAB -1666.0
SFN 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
YWHAE -10611.0
CDC25C -10299.0
CHEK2 -9675.5
WEE1 -9251.0
YWHAG -8883.0
CHEK1 -8742.0
CCNB1 -8105.0
YWHAZ -6950.0
YWHAQ -6859.0
YWHAH -6166.0
CDK1 -5335.0
YWHAB -1666.0
SFN 0.5


alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
1178
set alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize 10
pANOVA 0.043
s.dist -0.369
p.adjustANOVA 0.152



Top enriched genes

Top 20 genes
GeneID Gene Rank
FADS1 -10229.0
FADS2 -9923.0
ACOX1 -9782.0
SCP2 -9693.0
ELOVL5 -9172.0
ELOVL1 -7685.0
ACAA1 -6377.0
ACOT8 -4843.5
ACSL1 -3900.0
HSD17B4 560.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FADS1 -10229.0
FADS2 -9923.0
ACOX1 -9782.0
SCP2 -9693.0
ELOVL5 -9172.0
ELOVL1 -7685.0
ACAA1 -6377.0
ACOT8 -4843.5
ACSL1 -3900.0
HSD17B4 560.0


alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism
1179
set alpha-linolenic acid (ALA) metabolism
setSize 10
pANOVA 0.043
s.dist -0.369
p.adjustANOVA 0.152



Top enriched genes

Top 20 genes
GeneID Gene Rank
FADS1 -10229.0
FADS2 -9923.0
ACOX1 -9782.0
SCP2 -9693.0
ELOVL5 -9172.0
ELOVL1 -7685.0
ACAA1 -6377.0
ACOT8 -4843.5
ACSL1 -3900.0
HSD17B4 560.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FADS1 -10229.0
FADS2 -9923.0
ACOX1 -9782.0
SCP2 -9693.0
ELOVL5 -9172.0
ELOVL1 -7685.0
ACAA1 -6377.0
ACOT8 -4843.5
ACSL1 -3900.0
HSD17B4 560.0


Gluconeogenesis

Gluconeogenesis
380
set Gluconeogenesis
setSize 24
pANOVA 0.00191
s.dist -0.366
p.adjustANOVA 0.0237



Top enriched genes

Top 20 genes
GeneID Gene Rank
GAPDH -10813.0
PCK2 -10723.0
TPI1 -10628.0
SLC25A1 -10426.0
GOT1 -9768.0
GOT2 -9263.0
GPI -8514.0
G6PC3 -8379.0
MDH2 -8127.0
SLC37A2 -8039.0
ENO2 -7962.0
MDH1 -7654.0
SLC25A13 -7635.0
PGAM1 -7579.0
SLC25A12 -7458.0
ALDOA -6920.0
SLC25A11 -6308.5
ALDOC -6233.0
PC -6029.0
SLC37A1 -4867.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GAPDH -10813.0
PCK2 -10723.0
TPI1 -10628.0
SLC25A1 -10426.0
GOT1 -9768.0
GOT2 -9263.0
GPI -8514.0
G6PC3 -8379.0
MDH2 -8127.0
SLC37A2 -8039.0
ENO2 -7962.0
MDH1 -7654.0
SLC25A13 -7635.0
PGAM1 -7579.0
SLC25A12 -7458.0
ALDOA -6920.0
SLC25A11 -6308.5
ALDOC -6233.0
PC -6029.0
SLC37A1 -4867.0
SLC37A4 -3010.0
ENO3 -2830.0
FBP1 -1545.0
ENO1 767.0


Sema4D in semaphorin signaling

Sema4D in semaphorin signaling
932
set Sema4D in semaphorin signaling
setSize 15
pANOVA 0.015
s.dist 0.363
p.adjustANOVA 0.0744



Top enriched genes

Top 20 genes
GeneID Gene Rank
SEMA4D 827.0
MYH10 658.0
ARHGEF12 0.5
LIMK1 0.5
ARHGAP35 0.5
RRAS -1199.0
ERBB2 -1473.0
MYL6 -1879.0
ROCK1 -2506.0
MYH9 -3422.0
RHOB -4051.0
RHOA -4615.5
LIMK2 -5608.0
RND1 -6869.0
RAC1 -10546.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SEMA4D 827.0
MYH10 658.0
ARHGEF12 0.5
LIMK1 0.5
ARHGAP35 0.5
RRAS -1199.0
ERBB2 -1473.0
MYL6 -1879.0
ROCK1 -2506.0
MYH9 -3422.0
RHOB -4051.0
RHOA -4615.5
LIMK2 -5608.0
RND1 -6869.0
RAC1 -10546.0


TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
1072
set TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
setSize 12
pANOVA 0.0302
s.dist -0.361
p.adjustANOVA 0.12



Top enriched genes

Top 20 genes
GeneID Gene Rank
E2F7 -10460.0
CCNE1 -10018.0
PCBP4 -8428.0
CDKN1B -8363.0
CCNA2 -8185.0
E2F8 -7784.0
E2F1 -7716.0
TP53 -7435.5
ARID3A -6158.0
CCNE2 -5378.0
CDK2 -4743.0
CDKN1A 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
E2F7 -10460.0
CCNE1 -10018.0
PCBP4 -8428.0
CDKN1B -8363.0
CCNA2 -8185.0
E2F8 -7784.0
E2F1 -7716.0
TP53 -7435.5
ARID3A -6158.0
CCNE2 -5378.0
CDK2 -4743.0
CDKN1A 0.5


Striated Muscle Contraction

Striated Muscle Contraction
1033
set Striated Muscle Contraction
setSize 10
pANOVA 0.0497
s.dist -0.358
p.adjustANOVA 0.168



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACTN3 -10701.0
TMOD2 -10001.0
TMOD3 -9280.0
TPM3 -8556.0
TPM4 -7591.0
TPM1 -6931.0
TNNC1 -5859.5
TPM2 -5753.0
MYBPC2 -4231.0
VIM -1475.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACTN3 -10701.0
TMOD2 -10001.0
TMOD3 -9280.0
TPM3 -8556.0
TPM4 -7591.0
TPM1 -6931.0
TNNC1 -5859.5
TPM2 -5753.0
MYBPC2 -4231.0
VIM -1475.0


Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)
1042
set Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize 10
pANOVA 0.0507
s.dist 0.357
p.adjustANOVA 0.17



Top enriched genes

Top 20 genes
GeneID Gene Rank
GGT1 0.5
ALOX5AP -968.0
LTA4H -1408.0
MAPKAPK2 -1532.0
CYP4F22 -1910.0
DPEP2 -2221.0
LTC4S -2671.0
PTGR1 -3235.0
ALOX5 -5537.0
ABCC1 -7983.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GGT1 0.5
ALOX5AP -968.0
LTA4H -1408.0
MAPKAPK2 -1532.0
CYP4F22 -1910.0
DPEP2 -2221.0
LTC4S -2671.0
PTGR1 -3235.0
ALOX5 -5537.0
ABCC1 -7983.0


Other semaphorin interactions

Other semaphorin interactions
664
set Other semaphorin interactions
setSize 10
pANOVA 0.0508
s.dist 0.357
p.adjustANOVA 0.17



Top enriched genes

Top 20 genes
GeneID Gene Rank
SEMA4D 827.0
TYROBP 0.5
PLXNA2 0.5
SEMA4A 0.5
PTPRC 0.5
CD72 -703.0
PLXND1 -3973.0
ITGA1 -6005.5
PLXNC1 -7565.0
SEMA7A -10056.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SEMA4D 827.0
TYROBP 0.5
PLXNA2 0.5
SEMA4A 0.5
PTPRC 0.5
CD72 -703.0
PLXND1 -3973.0
ITGA1 -6005.5
PLXNC1 -7565.0
SEMA7A -10056.0


Synthesis of glycosylphosphatidylinositol (GPI)

Synthesis of glycosylphosphatidylinositol (GPI)
1050
set Synthesis of glycosylphosphatidylinositol (GPI)
setSize 14
pANOVA 0.021
s.dist -0.356
p.adjustANOVA 0.0929



Top enriched genes

Top 20 genes
GeneID Gene Rank
PIGL -10125.0
PIGQ -9927.0
PIGC -9727.5
PIGX -9372.0
PIGY -9324.0
PIGV -9012.0
PIGP -7737.5
PIGO -7557.0
PIGM -6397.0
PIGH -5173.0
PIGW -4205.5
PIGN -3918.5
DPM2 -3116.0
PIGF -2759.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIGL -10125.0
PIGQ -9927.0
PIGC -9727.5
PIGX -9372.0
PIGY -9324.0
PIGV -9012.0
PIGP -7737.5
PIGO -7557.0
PIGM -6397.0
PIGH -5173.0
PIGW -4205.5
PIGN -3918.5
DPM2 -3116.0
PIGF -2759.5


mRNA Capping

mRNA Capping
1181
set mRNA Capping
setSize 26
pANOVA 0.00166
s.dist -0.356
p.adjustANOVA 0.0211



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
RNMT -10663.0
POLR2L -10402.5
POLR2F -10326.5
GTF2H4 -10323.0
GTF2H3 -10227.5
POLR2A -10101.0
POLR2B -9678.0
NCBP2 -9664.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
SUPT5H -7677.0
CCNH -7336.0
GTF2F2 -6749.0
POLR2E -6287.0
ERCC2 -5966.0
POLR2G -4807.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10862.5
POLR2D -10789.0
RNMT -10663.0
POLR2L -10402.5
POLR2F -10326.5
GTF2H4 -10323.0
GTF2H3 -10227.5
POLR2A -10101.0
POLR2B -9678.0
NCBP2 -9664.0
GTF2F1 -9008.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
SUPT5H -7677.0
CCNH -7336.0
GTF2F2 -6749.0
POLR2E -6287.0
ERCC2 -5966.0
POLR2G -4807.0
GTF2H5 -3346.5
CDK7 -2530.0
ERCC3 -1107.0
MNAT1 -1059.0
RNGTT 743.0
POLR2K 759.0


PIWI-interacting RNA (piRNA) biogenesis

PIWI-interacting RNA (piRNA) biogenesis
677
set PIWI-interacting RNA (piRNA) biogenesis
setSize 16
pANOVA 0.0136
s.dist -0.356
p.adjustANOVA 0.0698



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
HSP90AA1 -7244.0
HENMT1 -7238.0
POLR2E -6287.0
POLR2G -4807.0
TDRKH -4257.0
PLD6 -4020.0
MYBL1 -2810.0
POLR2K 759.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
HSP90AA1 -7244.0
HENMT1 -7238.0
POLR2E -6287.0
POLR2G -4807.0
TDRKH -4257.0
PLD6 -4020.0
MYBL1 -2810.0
POLR2K 759.0


GAB1 signalosome

GAB1 signalosome
355
set GAB1 signalosome
setSize 10
pANOVA 0.0512
s.dist -0.356
p.adjustANOVA 0.17



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 -10484
PTPN11 -10423
PIK3R1 -9176
PAG1 -8615
TGFA -6965
SRC -6366
PIK3CA -6171
PXN -6064
HBEGF -3978
CSK -1994

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 -10484
PTPN11 -10423
PIK3R1 -9176
PAG1 -8615
TGFA -6965
SRC -6366
PIK3CA -6171
PXN -6064
HBEGF -3978
CSK -1994


Elevation of cytosolic Ca2+ levels

Elevation of cytosolic Ca2+ levels
285
set Elevation of cytosolic Ca2+ levels
setSize 10
pANOVA 0.0535
s.dist -0.353
p.adjustANOVA 0.175



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITPR2 -10842.0
ITPR1 -10668.0
ITPR3 -10210.0
P2RX4 -8861.0
P2RX6 -8786.0
ORAI1 -8382.0
P2RX5 -8036.0
ORAI2 -3442.0
P2RX1 -803.0
STIM1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITPR2 -10842.0
ITPR1 -10668.0
ITPR3 -10210.0
P2RX4 -8861.0
P2RX6 -8786.0
ORAI1 -8382.0
P2RX5 -8036.0
ORAI2 -3442.0
P2RX1 -803.0
STIM1 0.5


Interleukin-6 signaling

Interleukin-6 signaling
483
set Interleukin-6 signaling
setSize 10
pANOVA 0.0546
s.dist -0.351
p.adjustANOVA 0.177



Top enriched genes

Top 20 genes
GeneID Gene Rank
TYK2 -10475
PTPN11 -10423
STAT3 -10394
STAT1 -9583
IL6R -8317
JAK1 -7510
JAK2 -5287
IL6ST -5251
SOCS3 -1671
CBL -1022

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TYK2 -10475
PTPN11 -10423
STAT3 -10394
STAT1 -9583
IL6R -8317
JAK1 -7510
JAK2 -5287
IL6ST -5251
SOCS3 -1671
CBL -1022


Interleukin-35 Signalling

Interleukin-35 Signalling
479
set Interleukin-35 Signalling
setSize 11
pANOVA 0.0454
s.dist -0.348
p.adjustANOVA 0.158



Top enriched genes

Top 20 genes
GeneID Gene Rank
TYK2 -10475
IL27RA -10408
STAT3 -10394
STAT1 -9583
IL12RB2 -7837
JAK1 -7510
JAK2 -5287
IL6ST -5251
CANX -4313
STAT4 -3593
IL12A -2102

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TYK2 -10475
IL27RA -10408
STAT3 -10394
STAT1 -9583
IL12RB2 -7837
JAK1 -7510
JAK2 -5287
IL6ST -5251
CANX -4313
STAT4 -3593
IL12A -2102


TRAF6 mediated IRF7 activation

TRAF6 mediated IRF7 activation
1076
set TRAF6 mediated IRF7 activation
setSize 16
pANOVA 0.0179
s.dist -0.342
p.adjustANOVA 0.0837



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRF3 -10445.5
TRIM25 -10367.0
RNF135 -9806.0
IRF7 -9561.0
TRAF6 -9310.0
MAVS -8715.0
EP300 -8403.0
TBK1 -8176.0
IKBKE -6888.0
SIKE1 -6648.0
TRAF2 -5920.0
DDX58 -5873.0
TANK -4881.0
IFIH1 -2979.0
TRIM4 -1854.0
CREBBP -1182.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRF3 -10445.5
TRIM25 -10367.0
RNF135 -9806.0
IRF7 -9561.0
TRAF6 -9310.0
MAVS -8715.0
EP300 -8403.0
TBK1 -8176.0
IKBKE -6888.0
SIKE1 -6648.0
TRAF2 -5920.0
DDX58 -5873.0
TANK -4881.0
IFIH1 -2979.0
TRIM4 -1854.0
CREBBP -1182.0


Defects in vitamin and cofactor metabolism

Defects in vitamin and cofactor metabolism
217
set Defects in vitamin and cofactor metabolism
setSize 16
pANOVA 0.0204
s.dist -0.335
p.adjustANOVA 0.0914



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCCC1 -10799.0
MMAB -10782.5
MTR -10073.0
ACACA -9910.0
MMAA -8367.0
MMACHC -7799.5
PCCB -7542.0
ABCD4 -7345.0
MTRR -6522.0
PC -6029.0
HLCS -5227.0
MCCC2 -5218.0
MMADHC -5161.0
CD320 -4535.0
BTD -3192.5
LMBRD1 -1833.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCCC1 -10799.0
MMAB -10782.5
MTR -10073.0
ACACA -9910.0
MMAA -8367.0
MMACHC -7799.5
PCCB -7542.0
ABCD4 -7345.0
MTRR -6522.0
PC -6029.0
HLCS -5227.0
MCCC2 -5218.0
MMADHC -5161.0
CD320 -4535.0
BTD -3192.5
LMBRD1 -1833.0


Disorders of Developmental Biology

Disorders of Developmental Biology
248
set Disorders of Developmental Biology
setSize 10
pANOVA 0.0674
s.dist -0.334
p.adjustANOVA 0.203



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKACA -10527
NCOR1 -9820
CALM1 -7964
HDAC3 -7836
SIN3A -7398
CAMK4 -7119
HDAC1 -6856
GPS2 -6531
TBL1XR1 -3381
NCOR2 -1486

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKACA -10527
NCOR1 -9820
CALM1 -7964
HDAC3 -7836
SIN3A -7398
CAMK4 -7119
HDAC1 -6856
GPS2 -6531
TBL1XR1 -3381
NCOR2 -1486


Disorders of Nervous System Development

Disorders of Nervous System Development
249
set Disorders of Nervous System Development
setSize 10
pANOVA 0.0674
s.dist -0.334
p.adjustANOVA 0.203



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKACA -10527
NCOR1 -9820
CALM1 -7964
HDAC3 -7836
SIN3A -7398
CAMK4 -7119
HDAC1 -6856
GPS2 -6531
TBL1XR1 -3381
NCOR2 -1486

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKACA -10527
NCOR1 -9820
CALM1 -7964
HDAC3 -7836
SIN3A -7398
CAMK4 -7119
HDAC1 -6856
GPS2 -6531
TBL1XR1 -3381
NCOR2 -1486


Loss of function of MECP2 in Rett syndrome

Loss of function of MECP2 in Rett syndrome
515
set Loss of function of MECP2 in Rett syndrome
setSize 10
pANOVA 0.0674
s.dist -0.334
p.adjustANOVA 0.203



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKACA -10527
NCOR1 -9820
CALM1 -7964
HDAC3 -7836
SIN3A -7398
CAMK4 -7119
HDAC1 -6856
GPS2 -6531
TBL1XR1 -3381
NCOR2 -1486

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKACA -10527
NCOR1 -9820
CALM1 -7964
HDAC3 -7836
SIN3A -7398
CAMK4 -7119
HDAC1 -6856
GPS2 -6531
TBL1XR1 -3381
NCOR2 -1486


Pervasive developmental disorders

Pervasive developmental disorders
695
set Pervasive developmental disorders
setSize 10
pANOVA 0.0674
s.dist -0.334
p.adjustANOVA 0.203



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKACA -10527
NCOR1 -9820
CALM1 -7964
HDAC3 -7836
SIN3A -7398
CAMK4 -7119
HDAC1 -6856
GPS2 -6531
TBL1XR1 -3381
NCOR2 -1486

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKACA -10527
NCOR1 -9820
CALM1 -7964
HDAC3 -7836
SIN3A -7398
CAMK4 -7119
HDAC1 -6856
GPS2 -6531
TBL1XR1 -3381
NCOR2 -1486


Competing endogenous RNAs (ceRNAs) regulate PTEN translation

Competing endogenous RNAs (ceRNAs) regulate PTEN translation
162
set Competing endogenous RNAs (ceRNAs) regulate PTEN translation
setSize 10
pANOVA 0.0687
s.dist 0.332
p.adjustANOVA 0.204



Top enriched genes

Top 20 genes
GeneID Gene Rank
MIR19A 975.0
AGO3 0.5
AGO1 0.5
MIR17 -898.0
AGO2 -1081.0
TNRC6B -3201.0
MOV10 -3386.0
CNOT6L -5864.0
VAPA -7717.0
TNRC6A -7756.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MIR19A 975.0
AGO3 0.5
AGO1 0.5
MIR17 -898.0
AGO2 -1081.0
TNRC6B -3201.0
MOV10 -3386.0
CNOT6L -5864.0
VAPA -7717.0
TNRC6A -7756.0


Assembly of the ORC complex at the origin of replication

Assembly of the ORC complex at the origin of replication
66
set Assembly of the ORC complex at the origin of replication
setSize 10
pANOVA 0.0687
s.dist 0.332
p.adjustANOVA 0.204



Top enriched genes

Top 20 genes
GeneID Gene Rank
ORC1 1032.0
KPNA6 867.0
ORC3 0.5
ORC5 -863.0
ORC6 -1254.0
ORC4 -2543.5
ORC2 -3134.0
KPNB1 -5598.0
H2AFX -7725.0
KPNA1 -9710.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC1 1032.0
KPNA6 867.0
ORC3 0.5
ORC5 -863.0
ORC6 -1254.0
ORC4 -2543.5
ORC2 -3134.0
KPNB1 -5598.0
H2AFX -7725.0
KPNA1 -9710.0


SUMOylation of immune response proteins

SUMOylation of immune response proteins
922
set SUMOylation of immune response proteins
setSize 10
pANOVA 0.0716
s.dist -0.329
p.adjustANOVA 0.21



Top enriched genes

Top 20 genes
GeneID Gene Rank
NFKB2 -10075
UBE2I -9366
PIAS4 -8607
RELA -8524
PIAS3 -7043
IKBKE -6888
NFKBIA -5855
SUMO1 -5008
TOPORS -3797
SUMO3 -3456

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NFKB2 -10075
UBE2I -9366
PIAS4 -8607
RELA -8524
PIAS3 -7043
IKBKE -6888
NFKBIA -5855
SUMO1 -5008
TOPORS -3797
SUMO3 -3456


Purine salvage

Purine salvage
745
set Purine salvage
setSize 11
pANOVA 0.0591
s.dist -0.329
p.adjustANOVA 0.186



Top enriched genes

Top 20 genes
GeneID Gene Rank
GMPR2 -10303.5
APRT -9822.0
AMPD2 -9537.0
ADK -8719.0
ADAL -8040.5
DCK -7978.0
DGUOK -6848.0
AMPD3 -4775.0
GMPR -4491.0
PNP -2655.0
ADA -2283.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GMPR2 -10303.5
APRT -9822.0
AMPD2 -9537.0
ADK -8719.0
ADAL -8040.5
DCK -7978.0
DGUOK -6848.0
AMPD3 -4775.0
GMPR -4491.0
PNP -2655.0
ADA -2283.0


Metabolism of folate and pterines

Metabolism of folate and pterines
544
set Metabolism of folate and pterines
setSize 11
pANOVA 0.0596
s.dist -0.328
p.adjustANOVA 0.188



Top enriched genes

Top 20 genes
GeneID Gene Rank
MTHFR -10822.0
DHFR -9936.5
MTHFD2 -8653.0
MTHFS -8396.0
SLC19A1 -8147.0
SHMT1 -6627.0
MTHFD1L -5106.0
SLC25A32 -4919.5
SHMT2 -4866.0
FPGS -4591.0
MTHFD1 -3345.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTHFR -10822.0
DHFR -9936.5
MTHFD2 -8653.0
MTHFS -8396.0
SLC19A1 -8147.0
SHMT1 -6627.0
MTHFD1L -5106.0
SLC25A32 -4919.5
SHMT2 -4866.0
FPGS -4591.0
MTHFD1 -3345.0


Transport of Mature mRNAs Derived from Intronless Transcripts

Transport of Mature mRNAs Derived from Intronless Transcripts
1139
set Transport of Mature mRNAs Derived from Intronless Transcripts
setSize 41
pANOVA 0.000281
s.dist -0.328
p.adjustANOVA 0.00733



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10862.5
NUP153 -10583.0
NXF1 -10178.0
NUP37 -10126.0
NUP155 -9809.0
NCBP2 -9664.0
EIF4E -9599.0
CPSF4 -9543.5
CPSF2 -9271.5
SYMPK -9204.0
SEC13 -9014.0
FIP1L1 -8873.0
NUP93 -8851.0
NUP88 -8798.5
RANBP2 -8358.0
NUP50 -8012.0
CPSF1 -7981.0
NUP210 -7795.0
CPSF3 -7711.5
SLBP -7597.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10862.5
NUP153 -10583.0
NXF1 -10178.0
NUP37 -10126.0
NUP155 -9809.0
NCBP2 -9664.0
EIF4E -9599.0
CPSF4 -9543.5
CPSF2 -9271.5
SYMPK -9204.0
SEC13 -9014.0
FIP1L1 -8873.0
NUP93 -8851.0
NUP88 -8798.5
RANBP2 -8358.0
NUP50 -8012.0
CPSF1 -7981.0
NUP210 -7795.0
CPSF3 -7711.5
SLBP -7597.0
NUP62 -7589.5
WDR33 -7350.0
NUP98 -7237.0
TPR -7231.0
NUP54 -7099.0
NUP160 -7084.0
NUP43 -6915.0
NUP188 -6891.5
NUP214 -6845.0
POM121C -6709.0
NUP133 -5452.0
RAE1 -4647.0
NUP85 -4352.0
AAAS -3433.0
POM121 -2858.0
ALYREF -2689.0
SEH1L -2487.0
NUP35 -1584.0
NUP107 -1225.0
NDC1 0.5
NUP205 648.0


Purine ribonucleoside monophosphate biosynthesis

Purine ribonucleoside monophosphate biosynthesis
744
set Purine ribonucleoside monophosphate biosynthesis
setSize 10
pANOVA 0.0752
s.dist -0.325
p.adjustANOVA 0.217



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATIC -10393.0
GMPS -8964.0
IMPDH2 -8238.0
PFAS -7829.0
IMPDH1 -7414.0
ADSS -5882.0
PAICS -5741.5
PPAT -5741.5
ADSL -5039.0
ADSSL1 -3131.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATIC -10393.0
GMPS -8964.0
IMPDH2 -8238.0
PFAS -7829.0
IMPDH1 -7414.0
ADSS -5882.0
PAICS -5741.5
PPAT -5741.5
ADSL -5039.0
ADSSL1 -3131.0


Transport of Mature mRNA Derived from an Intronless Transcript

Transport of Mature mRNA Derived from an Intronless Transcript
1137
set Transport of Mature mRNA Derived from an Intronless Transcript
setSize 40
pANOVA 0.00038
s.dist -0.325
p.adjustANOVA 0.00932



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10862.5
NUP153 -10583.0
NXF1 -10178.0
NUP37 -10126.0
NUP155 -9809.0
NCBP2 -9664.0
EIF4E -9599.0
CPSF4 -9543.5
CPSF2 -9271.5
SYMPK -9204.0
SEC13 -9014.0
FIP1L1 -8873.0
NUP93 -8851.0
NUP88 -8798.5
RANBP2 -8358.0
NUP50 -8012.0
CPSF1 -7981.0
NUP210 -7795.0
CPSF3 -7711.5
NUP62 -7589.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10862.5
NUP153 -10583.0
NXF1 -10178.0
NUP37 -10126.0
NUP155 -9809.0
NCBP2 -9664.0
EIF4E -9599.0
CPSF4 -9543.5
CPSF2 -9271.5
SYMPK -9204.0
SEC13 -9014.0
FIP1L1 -8873.0
NUP93 -8851.0
NUP88 -8798.5
RANBP2 -8358.0
NUP50 -8012.0
CPSF1 -7981.0
NUP210 -7795.0
CPSF3 -7711.5
NUP62 -7589.5
WDR33 -7350.0
NUP98 -7237.0
TPR -7231.0
NUP54 -7099.0
NUP160 -7084.0
NUP43 -6915.0
NUP188 -6891.5
NUP214 -6845.0
POM121C -6709.0
NUP133 -5452.0
RAE1 -4647.0
NUP85 -4352.0
AAAS -3433.0
POM121 -2858.0
ALYREF -2689.0
SEH1L -2487.0
NUP35 -1584.0
NUP107 -1225.0
NDC1 0.5
NUP205 648.0


MicroRNA (miRNA) biogenesis

MicroRNA (miRNA) biogenesis
559
set MicroRNA (miRNA) biogenesis
setSize 21
pANOVA 0.0101
s.dist -0.324
p.adjustANOVA 0.0582



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKRA -10867.5
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
XPO5 -9383.5
DICER1 -9050.5
TARBP2 -8855.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
RAN -7757.0
POLR2E -6287.0
BCDIN3D -5692.0
POLR2G -4807.0
DGCR8 -3979.0
AGO2 -1081.0
AGO3 0.5
AGO1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKRA -10867.5
POLR2D -10789.0
POLR2L -10402.5
POLR2F -10326.5
POLR2A -10101.0
POLR2B -9678.0
XPO5 -9383.5
DICER1 -9050.5
TARBP2 -8855.0
POLR2C -8847.0
POLR2H -8272.0
POLR2I -8056.5
RAN -7757.0
POLR2E -6287.0
BCDIN3D -5692.0
POLR2G -4807.0
DGCR8 -3979.0
AGO2 -1081.0
AGO3 0.5
AGO1 0.5
POLR2K 759.0


Sema3A PAK dependent Axon repulsion

Sema3A PAK dependent Axon repulsion
931
set Sema3A PAK dependent Axon repulsion
setSize 11
pANOVA 0.0625
s.dist 0.324
p.adjustANOVA 0.194



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSP90AB1 888.0
SEMA3A 0.5
PAK2 0.5
PLXNA2 0.5
LIMK1 0.5
PAK1 -1637.0
FES -3515.0
FYN -4179.0
CFL1 -6125.0
HSP90AA1 -7244.0
RAC1 -10546.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSP90AB1 888.0
SEMA3A 0.5
PAK2 0.5
PLXNA2 0.5
LIMK1 0.5
PAK1 -1637.0
FES -3515.0
FYN -4179.0
CFL1 -6125.0
HSP90AA1 -7244.0
RAC1 -10546.0


Binding and Uptake of Ligands by Scavenger Receptors

Binding and Uptake of Ligands by Scavenger Receptors
85
set Binding and Uptake of Ligands by Scavenger Receptors
setSize 10
pANOVA 0.0801
s.dist -0.32
p.adjustANOVA 0.227



Top enriched genes

Top 20 genes
GeneID Gene Rank
SCARB1 -10110
CALR -8492
HSPH1 -8200
HSP90AA1 -7244
FTL -7133
APOA1 -6790
HYOU1 -6760
FTH1 -4960
COL1A1 -4755
HSP90B1 -3606

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SCARB1 -10110
CALR -8492
HSPH1 -8200
HSP90AA1 -7244
FTL -7133
APOA1 -6790
HYOU1 -6760
FTH1 -4960
COL1A1 -4755
HSP90B1 -3606


Deposition of new CENPA-containing nucleosomes at the centromere

Deposition of new CENPA-containing nucleosomes at the centromere
226
set Deposition of new CENPA-containing nucleosomes at the centromere
setSize 23
pANOVA 0.0086
s.dist -0.316
p.adjustANOVA 0.0527



Top enriched genes

Top 20 genes
GeneID Gene Rank
CENPT -10866.0
RBBP4 -9756.5
CENPH -9736.0
CENPK -9517.5
ITGB3BP -9385.5
HJURP -9302.0
CENPP -9094.5
RUVBL1 -8764.0
CENPO -8463.0
RSF1 -8345.0
H2AFX -7725.0
CENPN -6502.0
CENPL -6420.5
CENPA -5554.0
APITD1 -5431.0
SMARCA5 -5382.0
CENPQ -5359.5
CENPM -4849.0
MIS18A -4282.0
CENPU -3820.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CENPT -10866.0
RBBP4 -9756.5
CENPH -9736.0
CENPK -9517.5
ITGB3BP -9385.5
HJURP -9302.0
CENPP -9094.5
RUVBL1 -8764.0
CENPO -8463.0
RSF1 -8345.0
H2AFX -7725.0
CENPN -6502.0
CENPL -6420.5
CENPA -5554.0
APITD1 -5431.0
SMARCA5 -5382.0
CENPQ -5359.5
CENPM -4849.0
MIS18A -4282.0
CENPU -3820.0
STRA13 -3789.0
OIP5 -3705.5
MIS18BP1 0.5


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report