date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##           metric
## PSMB8  -15.55549
## TRIM27 -19.85078
## NBPF20 -14.58336
## TAPBP  -15.46688
## RAB1B  -13.48874
## TAP1   -14.98539
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2546
num_genes_in_profile 12012
duplicated_genes_present 0
num_profile_genes_in_sets 5835
num_profile_genes_not_in_sets 6177

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2546
num_genesets_excluded 1344
num_genesets_included 1202

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
TNFs bind their physiological receptors 10 2.41e-03 0.554 0.011200
Defects in vitamin and cofactor metabolism 16 5.55e-04 -0.499 0.003740
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 19 2.18e-04 -0.490 0.001800
Caspase activation via Death Receptors in the presence of ligand 10 8.09e-03 -0.484 0.029000
Prefoldin mediated transfer of substrate to CCT/TriC 17 9.03e-04 -0.465 0.005120
Purine salvage 11 7.73e-03 -0.464 0.028100
Inhibition of DNA recombination at telomere 18 7.33e-04 -0.460 0.004330
Meiotic recombination 19 5.55e-04 -0.458 0.003740
Signaling by FGFR2 IIIa TM 15 2.80e-03 -0.446 0.012600
Condensation of Prometaphase Chromosomes 10 1.54e-02 -0.442 0.048000
RIPK1-mediated regulated necrosis 25 1.64e-04 -0.436 0.001510
Regulation of necroptotic cell death 25 1.64e-04 -0.436 0.001510
Glycogen synthesis 11 1.45e-02 -0.426 0.046000
Voltage gated Potassium channels 13 8.17e-03 0.424 0.029100
Formation of tubulin folding intermediates by CCT/TriC 14 7.67e-03 -0.412 0.027900
Removal of the Flap Intermediate 12 1.78e-02 -0.395 0.054000
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 1.50e-02 -0.390 0.047100
mRNA decay by 5’ to 3’ exoribonuclease 15 9.28e-03 -0.388 0.032300
Assembly of the ORC complex at the origin of replication 10 3.37e-02 0.388 0.087500
SARS-CoV-2 modulates autophagy 11 2.79e-02 -0.383 0.076100
HDR through MMEJ (alt-NHEJ) 11 2.83e-02 -0.382 0.076500
Signaling by NOTCH2 18 5.44e-03 -0.378 0.021100
NRIF signals cell death from the nucleus 14 1.48e-02 -0.376 0.046700
Pexophagy 11 3.20e-02 -0.373 0.083900
Glyoxylate metabolism and glycine degradation 19 5.07e-03 -0.371 0.019700
IKK complex recruitment mediated by RIP1 17 8.43e-03 -0.369 0.029900
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 4.39e-02 -0.368 0.107000
alpha-linolenic acid (ALA) metabolism 10 4.39e-02 -0.368 0.107000
Translesion synthesis by POLK 15 1.40e-02 -0.366 0.044900
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 2.83e-02 -0.365 0.076500
Processive synthesis on the lagging strand 13 2.26e-02 -0.365 0.064000
Ubiquitin-dependent degradation of Cyclin D 44 2.97e-05 -0.364 0.000426
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 44 2.98e-05 -0.364 0.000426
p53-Independent DNA Damage Response 44 2.98e-05 -0.364 0.000426
p53-Independent G1/S DNA damage checkpoint 44 2.98e-05 -0.364 0.000426
HDR through Single Strand Annealing (SSA) 35 1.98e-04 -0.364 0.001670
Purine ribonucleoside monophosphate biosynthesis 10 4.70e-02 -0.363 0.111000
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 1.29e-02 -0.359 0.042400
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 1.29e-02 -0.359 0.042400
Autodegradation of the E3 ubiquitin ligase COP1 44 4.62e-05 -0.355 0.000585
Lagging Strand Synthesis 17 1.13e-02 -0.355 0.038300
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 2.20e-02 -0.353 0.063400
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 2.20e-02 -0.353 0.063400
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 4.25e-02 -0.353 0.105000
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 5.32e-02 0.353 0.122000
ERKs are inactivated 11 4.36e-02 -0.351 0.107000
Cross-presentation of soluble exogenous antigens (endosomes) 38 1.82e-04 -0.351 0.001610
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 4.47e-02 -0.350 0.108000
Ovarian tumor domain proteases 29 1.25e-03 -0.346 0.006640
SCF(Skp2)-mediated degradation of p27/p21 52 1.71e-05 -0.345 0.000287


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
TNFs bind their physiological receptors 10 2.41e-03 5.54e-01 1.12e-02
Defects in vitamin and cofactor metabolism 16 5.55e-04 -4.99e-01 3.74e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 19 2.18e-04 -4.90e-01 1.80e-03
Caspase activation via Death Receptors in the presence of ligand 10 8.09e-03 -4.84e-01 2.90e-02
Prefoldin mediated transfer of substrate to CCT/TriC 17 9.03e-04 -4.65e-01 5.12e-03
Purine salvage 11 7.73e-03 -4.64e-01 2.81e-02
Inhibition of DNA recombination at telomere 18 7.33e-04 -4.60e-01 4.33e-03
Meiotic recombination 19 5.55e-04 -4.58e-01 3.74e-03
Signaling by FGFR2 IIIa TM 15 2.80e-03 -4.46e-01 1.26e-02
Condensation of Prometaphase Chromosomes 10 1.54e-02 -4.42e-01 4.80e-02
RIPK1-mediated regulated necrosis 25 1.64e-04 -4.36e-01 1.51e-03
Regulation of necroptotic cell death 25 1.64e-04 -4.36e-01 1.51e-03
Glycogen synthesis 11 1.45e-02 -4.26e-01 4.60e-02
Voltage gated Potassium channels 13 8.17e-03 4.24e-01 2.91e-02
Formation of tubulin folding intermediates by CCT/TriC 14 7.67e-03 -4.12e-01 2.79e-02
Removal of the Flap Intermediate 12 1.78e-02 -3.95e-01 5.40e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 1.50e-02 -3.90e-01 4.71e-02
mRNA decay by 5’ to 3’ exoribonuclease 15 9.28e-03 -3.88e-01 3.23e-02
Assembly of the ORC complex at the origin of replication 10 3.37e-02 3.88e-01 8.75e-02
SARS-CoV-2 modulates autophagy 11 2.79e-02 -3.83e-01 7.61e-02
HDR through MMEJ (alt-NHEJ) 11 2.83e-02 -3.82e-01 7.65e-02
Signaling by NOTCH2 18 5.44e-03 -3.78e-01 2.11e-02
NRIF signals cell death from the nucleus 14 1.48e-02 -3.76e-01 4.67e-02
Pexophagy 11 3.20e-02 -3.73e-01 8.39e-02
Glyoxylate metabolism and glycine degradation 19 5.07e-03 -3.71e-01 1.97e-02
IKK complex recruitment mediated by RIP1 17 8.43e-03 -3.69e-01 2.99e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 4.39e-02 -3.68e-01 1.07e-01
alpha-linolenic acid (ALA) metabolism 10 4.39e-02 -3.68e-01 1.07e-01
Translesion synthesis by POLK 15 1.40e-02 -3.66e-01 4.49e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 2.83e-02 -3.65e-01 7.65e-02
Processive synthesis on the lagging strand 13 2.26e-02 -3.65e-01 6.40e-02
Ubiquitin-dependent degradation of Cyclin D 44 2.97e-05 -3.64e-01 4.26e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 44 2.98e-05 -3.64e-01 4.26e-04
p53-Independent DNA Damage Response 44 2.98e-05 -3.64e-01 4.26e-04
p53-Independent G1/S DNA damage checkpoint 44 2.98e-05 -3.64e-01 4.26e-04
HDR through Single Strand Annealing (SSA) 35 1.98e-04 -3.64e-01 1.67e-03
Purine ribonucleoside monophosphate biosynthesis 10 4.70e-02 -3.63e-01 1.11e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 1.29e-02 -3.59e-01 4.24e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 1.29e-02 -3.59e-01 4.24e-02
Autodegradation of the E3 ubiquitin ligase COP1 44 4.62e-05 -3.55e-01 5.85e-04
Lagging Strand Synthesis 17 1.13e-02 -3.55e-01 3.83e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 2.20e-02 -3.53e-01 6.34e-02
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 2.20e-02 -3.53e-01 6.34e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 4.25e-02 -3.53e-01 1.05e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 5.32e-02 3.53e-01 1.22e-01
ERKs are inactivated 11 4.36e-02 -3.51e-01 1.07e-01
Cross-presentation of soluble exogenous antigens (endosomes) 38 1.82e-04 -3.51e-01 1.61e-03
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 4.47e-02 -3.50e-01 1.08e-01
Ovarian tumor domain proteases 29 1.25e-03 -3.46e-01 6.64e-03
SCF(Skp2)-mediated degradation of p27/p21 52 1.71e-05 -3.45e-01 2.87e-04
RNA Pol II CTD phosphorylation and interaction with CE 24 3.62e-03 -3.43e-01 1.52e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 24 3.62e-03 -3.43e-01 1.52e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 3.97e-02 -3.43e-01 9.97e-02
Interleukin-6 signaling 10 6.06e-02 -3.43e-01 1.32e-01
Translesion synthesis by POLI 15 2.25e-02 -3.40e-01 6.40e-02
Anchoring of the basal body to the plasma membrane 80 1.61e-07 -3.39e-01 7.76e-06
Synaptic adhesion-like molecules 10 6.34e-02 3.39e-01 1.34e-01
mRNA Capping 26 2.95e-03 -3.37e-01 1.31e-02
Methylation 10 6.54e-02 -3.36e-01 1.37e-01
AURKA Activation by TPX2 59 8.14e-06 -3.36e-01 1.63e-04
Viral Messenger RNA Synthesis 41 1.98e-04 -3.36e-01 1.67e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 8.16e-05 -3.36e-01 9.61e-04
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 2.46e-02 -3.35e-01 6.83e-02
RUNX3 regulates p14-ARF 10 6.72e-02 -3.34e-01 1.39e-01
Loss of Nlp from mitotic centrosomes 56 1.58e-05 -3.34e-01 2.75e-04
Loss of proteins required for interphase microtubule organization from the centrosome 56 1.58e-05 -3.34e-01 2.75e-04
Impaired BRCA2 binding to RAD51 32 1.12e-03 -3.33e-01 6.10e-03
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 1.91e-04 -3.33e-01 1.65e-03
Translesion synthesis by REV1 14 3.24e-02 -3.30e-01 8.45e-02
Constitutive Signaling by EGFRvIII 10 7.27e-02 -3.28e-01 1.48e-01
Signaling by EGFRvIII in Cancer 10 7.27e-02 -3.28e-01 1.48e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 23 6.63e-03 -3.27e-01 2.47e-02
Striated Muscle Contraction 10 7.34e-02 -3.27e-01 1.49e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 2.88e-02 -3.26e-01 7.75e-02
Diseases of DNA repair 45 1.60e-04 -3.25e-01 1.51e-03
G2/M DNA damage checkpoint 54 3.66e-05 -3.25e-01 4.90e-04
p75NTR signals via NF-kB 11 6.33e-02 -3.23e-01 1.34e-01
Regulation of PTEN stability and activity 56 2.94e-05 -3.23e-01 4.26e-04
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 46 1.62e-04 -3.22e-01 1.51e-03
Degradation of GLI2 by the proteasome 50 8.62e-05 -3.21e-01 9.97e-04
GLI3 is processed to GLI3R by the proteasome 50 8.62e-05 -3.21e-01 9.97e-04
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 63 1.07e-05 -3.21e-01 2.11e-04
Processive synthesis on the C-strand of the telomere 17 2.21e-02 -3.21e-01 6.35e-02
Signaling by ERBB2 ECD mutants 10 7.93e-02 -3.20e-01 1.58e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 5.46e-02 -3.20e-01 1.23e-01
Notch-HLH transcription pathway 21 1.12e-02 -3.20e-01 3.81e-02
Autodegradation of Cdh1 by Cdh1:APC/C 56 3.58e-05 -3.19e-01 4.89e-04
SCF-beta-TrCP mediated degradation of Emi1 47 1.54e-04 -3.19e-01 1.51e-03
FGFR2 mutant receptor activation 17 2.32e-02 -3.18e-01 6.56e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 62 1.54e-05 -3.18e-01 2.75e-04
Regulation of Apoptosis 45 2.39e-04 -3.17e-01 1.95e-03
DNA Damage/Telomere Stress Induced Senescence 24 7.41e-03 -3.16e-01 2.73e-02
Cyclin A:Cdk2-associated events at S phase entry 74 2.71e-06 -3.16e-01 7.75e-05
TRAF6 mediated NF-kB activation 19 1.73e-02 -3.15e-01 5.32e-02
APC truncation mutants have impaired AXIN binding 12 5.90e-02 -3.15e-01 1.29e-01
AXIN missense mutants destabilize the destruction complex 12 5.90e-02 -3.15e-01 1.29e-01
Signaling by AMER1 mutants 12 5.90e-02 -3.15e-01 1.29e-01
Signaling by APC mutants 12 5.90e-02 -3.15e-01 1.29e-01
Signaling by AXIN mutants 12 5.90e-02 -3.15e-01 1.29e-01
Truncations of AMER1 destabilize the destruction complex 12 5.90e-02 -3.15e-01 1.29e-01
Signaling by FGFR2 in disease 24 7.67e-03 -3.14e-01 2.79e-02
Beta-catenin phosphorylation cascade 15 3.51e-02 -3.14e-01 9.03e-02
HIV Transcription Initiation 39 7.00e-04 -3.14e-01 4.25e-03
RNA Polymerase II HIV Promoter Escape 39 7.00e-04 -3.14e-01 4.25e-03
RNA Polymerase II Promoter Escape 39 7.00e-04 -3.14e-01 4.25e-03
RNA Polymerase II Transcription Initiation 39 7.00e-04 -3.14e-01 4.25e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance 39 7.00e-04 -3.14e-01 4.25e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 39 7.00e-04 -3.14e-01 4.25e-03
Interleukin-35 Signalling 11 7.19e-02 -3.13e-01 1.47e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 65 1.28e-05 -3.13e-01 2.45e-04
Separation of Sister Chromatids 147 6.48e-11 -3.13e-01 6.49e-09
APC/C:Cdc20 mediated degradation of Securin 58 4.11e-05 -3.12e-01 5.37e-04
InlB-mediated entry of Listeria monocytogenes into host cell 11 7.45e-02 -3.10e-01 1.51e-01
TP53 Regulates Transcription of DNA Repair Genes 52 1.13e-04 -3.10e-01 1.20e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 66 1.38e-05 -3.10e-01 2.58e-04
G1/S DNA Damage Checkpoints 58 4.58e-05 -3.10e-01 5.85e-04
Cyclin E associated events during G1/S transition 72 5.66e-06 -3.10e-01 1.38e-04
Cyclin A/B1/B2 associated events during G2/M transition 22 1.21e-02 -3.09e-01 3.99e-02
Elastic fibre formation 17 2.77e-02 3.08e-01 7.58e-02
FGFR2 alternative splicing 22 1.25e-02 -3.08e-01 4.11e-02
Vpu mediated degradation of CD4 44 4.14e-04 -3.08e-01 3.07e-03
Purine catabolism 10 9.20e-02 -3.08e-01 1.76e-01
Association of TriC/CCT with target proteins during biosynthesis 29 4.18e-03 -3.07e-01 1.70e-02
Stabilization of p53 49 1.99e-04 -3.07e-01 1.67e-03
Rev-mediated nuclear export of HIV RNA 33 2.36e-03 -3.06e-01 1.11e-02
Meiosis 42 6.12e-04 -3.06e-01 3.96e-03
Leading Strand Synthesis 12 6.70e-02 -3.05e-01 1.39e-01
Polymerase switching 12 6.70e-02 -3.05e-01 1.39e-01
Resolution of Sister Chromatid Cohesion 92 4.40e-07 -3.05e-01 1.89e-05
Vif-mediated degradation of APOBEC3G 43 5.42e-04 -3.05e-01 3.70e-03
Regulation of TP53 Activity through Phosphorylation 79 2.85e-06 -3.05e-01 7.97e-05
TICAM1, RIP1-mediated IKK complex recruitment 17 2.97e-02 -3.04e-01 7.91e-02
Degradation of AXIN 47 3.07e-04 -3.04e-01 2.43e-03
VLDLR internalisation and degradation 11 8.11e-02 -3.04e-01 1.60e-01
Mismatch Repair 13 5.80e-02 -3.04e-01 1.29e-01
Translesion Synthesis by POLH 17 3.03e-02 -3.03e-01 7.98e-02
TNFR1-induced proapoptotic signaling 12 6.91e-02 -3.03e-01 1.41e-01
Removal of the Flap Intermediate from the C-strand 15 4.23e-02 -3.03e-01 1.04e-01
p53-Dependent G1 DNA Damage Response 56 9.11e-05 -3.02e-01 1.03e-03
p53-Dependent G1/S DNA damage checkpoint 56 9.11e-05 -3.02e-01 1.03e-03
The role of GTSE1 in G2/M progression after G2 checkpoint 52 1.65e-04 -3.02e-01 1.52e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 64 2.98e-05 -3.02e-01 4.26e-04
Glycogen storage diseases 10 9.82e-02 -3.02e-01 1.83e-01
Base-Excision Repair, AP Site Formation 15 4.31e-02 -3.02e-01 1.06e-01
FLT3 signaling in disease 24 1.08e-02 -3.01e-01 3.69e-02
Regulation of RAS by GAPs 56 1.01e-04 -3.01e-01 1.09e-03
Degradation of GLI1 by the proteasome 51 2.12e-04 -3.00e-01 1.77e-03
Homologous DNA Pairing and Strand Exchange 39 1.21e-03 -3.00e-01 6.50e-03
Gap-filling DNA repair synthesis and ligation in TC-NER 55 1.22e-04 -3.00e-01 1.25e-03
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 69 1.71e-05 -3.00e-01 2.87e-04
Polo-like kinase mediated events 15 4.46e-02 -3.00e-01 1.08e-01
Long-term potentiation 11 8.67e-02 2.98e-01 1.69e-01
Negative regulation of NOTCH4 signaling 48 3.56e-04 -2.98e-01 2.75e-03
DNA strand elongation 28 6.39e-03 -2.98e-01 2.41e-02
Metabolism of folate and pterines 11 8.75e-02 -2.98e-01 1.69e-01
CTNNB1 S33 mutants aren’t phosphorylated 13 6.32e-02 -2.98e-01 1.34e-01
CTNNB1 S37 mutants aren’t phosphorylated 13 6.32e-02 -2.98e-01 1.34e-01
CTNNB1 S45 mutants aren’t phosphorylated 13 6.32e-02 -2.98e-01 1.34e-01
CTNNB1 T41 mutants aren’t phosphorylated 13 6.32e-02 -2.98e-01 1.34e-01
Signaling by CTNNB1 phospho-site mutants 13 6.32e-02 -2.98e-01 1.34e-01
Signaling by GSK3beta mutants 13 6.32e-02 -2.98e-01 1.34e-01
Diseases of mitotic cell cycle 34 2.72e-03 -2.97e-01 1.23e-02
Regulation of ornithine decarboxylase (ODC) 43 7.66e-04 -2.97e-01 4.47e-03
Base Excision Repair 38 1.60e-03 -2.96e-01 8.22e-03
RNA Polymerase I Promoter Escape 27 7.81e-03 -2.96e-01 2.83e-02
Vpr-mediated nuclear import of PICs 32 3.85e-03 -2.95e-01 1.61e-02
Processing of DNA double-strand break ends 55 1.60e-04 -2.94e-01 1.51e-03
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 37 1.96e-03 -2.94e-01 9.40e-03
Diseases of DNA Double-Strand Break Repair 37 1.96e-03 -2.94e-01 9.40e-03
PCNA-Dependent Long Patch Base Excision Repair 18 3.09e-02 -2.94e-01 8.12e-02
Negative regulation of FLT3 13 6.70e-02 -2.93e-01 1.39e-01
Homology Directed Repair 90 1.55e-06 -2.93e-01 5.03e-05
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 6.71e-02 -2.93e-01 1.39e-01
CDK-mediated phosphorylation and removal of Cdc6 62 6.91e-05 -2.92e-01 8.22e-04
RUNX1 regulates transcription of genes involved in differentiation of HSCs 57 1.36e-04 -2.92e-01 1.37e-03
Miscellaneous transport and binding events 14 5.83e-02 -2.92e-01 1.29e-01
Glycogen metabolism 17 3.70e-02 -2.92e-01 9.43e-02
Peptide ligand-binding receptors 20 2.37e-02 2.92e-01 6.64e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 1.10e-01 2.92e-01 2.00e-01
Dual incision in TC-NER 56 1.59e-04 -2.92e-01 1.51e-03
Interactions of Rev with host cellular proteins 34 3.28e-03 -2.91e-01 1.42e-02
RUNX3 regulates NOTCH signaling 11 9.45e-02 -2.91e-01 1.78e-01
Regulation of RUNX2 expression and activity 57 1.45e-04 -2.91e-01 1.44e-03
B-WICH complex positively regulates rRNA expression 27 9.07e-03 -2.90e-01 3.18e-02
LDL clearance 12 8.18e-02 -2.90e-01 1.61e-01
Diseases of programmed cell death 37 2.29e-03 -2.90e-01 1.08e-02
PIWI-interacting RNA (piRNA) biogenesis 16 4.49e-02 -2.90e-01 1.08e-01
HDR through Homologous Recombination (HRR) 60 1.08e-04 -2.89e-01 1.16e-03
Interactions of Vpr with host cellular proteins 33 4.07e-03 -2.89e-01 1.66e-02
Formation of TC-NER Pre-Incision Complex 46 7.03e-04 -2.89e-01 4.25e-03
Signaling by FLT3 ITD and TKD mutants 12 8.32e-02 -2.89e-01 1.63e-01
ER-Phagosome pathway 69 3.41e-05 -2.89e-01 4.71e-04
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 7.08e-04 -2.89e-01 4.25e-03
Signaling by CSF3 (G-CSF) 24 1.44e-02 -2.88e-01 4.60e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 83 5.86e-06 -2.88e-01 1.38e-04
Amplification of signal from the kinetochores 83 5.86e-06 -2.88e-01 1.38e-04
Degradation of cysteine and homocysteine 10 1.15e-01 -2.88e-01 2.08e-01
Hh mutants are degraded by ERAD 47 6.51e-04 -2.88e-01 4.17e-03
RNA Polymerase I Transcription Initiation 40 1.67e-03 -2.87e-01 8.43e-03
Signaling by NTRK2 (TRKB) 15 5.48e-02 -2.86e-01 1.23e-01
Diseases associated with N-glycosylation of proteins 18 3.55e-02 -2.86e-01 9.12e-02
RHO GTPases activate CIT 14 6.39e-02 -2.86e-01 1.35e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 27 1.01e-02 -2.86e-01 3.52e-02
Regulation of TP53 Expression and Degradation 34 3.93e-03 -2.86e-01 1.63e-02
Resolution of Abasic Sites (AP sites) 31 5.97e-03 -2.85e-01 2.29e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 26 1.20e-02 -2.85e-01 3.99e-02
Sulfur amino acid metabolism 17 4.28e-02 -2.84e-01 1.05e-01
Synthesis of glycosylphosphatidylinositol (GPI) 14 6.61e-02 -2.84e-01 1.38e-01
Signaling by NOTCH4 68 5.33e-05 -2.84e-01 6.48e-04
APC/C-mediated degradation of cell cycle proteins 77 1.74e-05 -2.83e-01 2.87e-04
Regulation of mitotic cell cycle 77 1.74e-05 -2.83e-01 2.87e-04
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 84 7.61e-06 -2.83e-01 1.62e-04
Export of Viral Ribonucleoproteins from Nucleus 31 6.45e-03 -2.83e-01 2.42e-02
Presynaptic phase of homologous DNA pairing and strand exchange 36 3.35e-03 -2.83e-01 1.45e-02
RNA Polymerase I Transcription Termination 25 1.46e-02 -2.82e-01 4.63e-02
Interleukin-20 family signaling 13 7.91e-02 -2.81e-01 1.58e-01
Mitotic Prometaphase 158 1.28e-09 -2.80e-01 9.61e-08
Inactivation of CSF3 (G-CSF) signaling 19 3.45e-02 -2.80e-01 8.90e-02
Mitochondrial tRNA aminoacylation 18 3.96e-02 -2.80e-01 9.96e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 15 6.04e-02 -2.80e-01 1.32e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 20 3.03e-02 -2.80e-01 7.98e-02
Antigen processing-Cross presentation 76 2.66e-05 -2.79e-01 4.11e-04
Signaling by EGFR in Cancer 16 5.38e-02 -2.78e-01 1.22e-01
Asymmetric localization of PCP proteins 51 5.94e-04 -2.78e-01 3.86e-03
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 16 5.41e-02 -2.78e-01 1.22e-01
Dectin-1 mediated noncanonical NF-kB signaling 52 5.33e-04 -2.78e-01 3.68e-03
Signaling by Retinoic Acid 17 4.76e-02 -2.78e-01 1.12e-01
Regulation of APC/C activators between G1/S and early anaphase 70 6.10e-05 -2.77e-01 7.33e-04
SRP-dependent cotranslational protein targeting to membrane 88 7.16e-06 -2.77e-01 1.56e-04
Golgi Cisternae Pericentriolar Stack Reorganization 14 7.29e-02 -2.77e-01 1.48e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 33 5.99e-03 -2.76e-01 2.29e-02
Positive epigenetic regulation of rRNA expression 40 2.49e-03 -2.76e-01 1.14e-02
Potassium Channels 30 8.92e-03 2.76e-01 3.13e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 9.80e-02 -2.76e-01 1.83e-01
NIK–>noncanonical NF-kB signaling 51 6.73e-04 -2.75e-01 4.25e-03
RHO GTPases Activate WASPs and WAVEs 29 1.03e-02 -2.75e-01 3.57e-02
HIV elongation arrest and recovery 27 1.34e-02 -2.75e-01 4.34e-02
Pausing and recovery of HIV elongation 27 1.34e-02 -2.75e-01 4.34e-02
Heme biosynthesis 10 1.32e-01 -2.75e-01 2.34e-01
Regulation of TP53 Degradation 33 6.43e-03 -2.74e-01 2.42e-02
Mitotic Spindle Checkpoint 98 3.03e-06 -2.73e-01 8.28e-05
SUMOylation of SUMOylation proteins 32 7.51e-03 -2.73e-01 2.76e-02
Hedgehog ligand biogenesis 52 6.74e-04 -2.73e-01 4.25e-03
RNA Polymerase I Promoter Clearance 44 1.81e-03 -2.72e-01 8.98e-03
RNA Polymerase I Transcription 44 1.81e-03 -2.72e-01 8.98e-03
Signaling by PDGFR in disease 15 6.83e-02 -2.72e-01 1.41e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 28 1.30e-02 -2.71e-01 4.26e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 28 1.30e-02 -2.71e-01 4.26e-02
MAPK6/MAPK4 signaling 69 1.01e-04 -2.71e-01 1.09e-03
Hh mutants abrogate ligand secretion 49 1.07e-03 -2.70e-01 5.92e-03
Regulation of RUNX3 expression and activity 49 1.08e-03 -2.70e-01 5.94e-03
Degradation of beta-catenin by the destruction complex 68 1.19e-04 -2.70e-01 1.23e-03
Mitotic Metaphase and Anaphase 196 8.64e-11 -2.70e-01 7.99e-09
Recruitment of NuMA to mitotic centrosomes 65 1.76e-04 -2.69e-01 1.59e-03
Transport of Mature mRNA Derived from an Intronless Transcript 40 3.27e-03 -2.69e-01 1.42e-02
Telomere C-strand synthesis initiation 10 1.41e-01 -2.69e-01 2.44e-01
Mitotic Anaphase 195 1.20e-10 -2.68e-01 1.03e-08
RHO GTPases activate PKNs 26 1.80e-02 -2.68e-01 5.46e-02
Senescence-Associated Secretory Phenotype (SASP) 42 2.73e-03 -2.67e-01 1.23e-02
TICAM1-dependent activation of IRF3/IRF7 12 1.09e-01 -2.67e-01 2.00e-01
Gluconeogenesis 24 2.38e-02 -2.67e-01 6.65e-02
Disorders of Developmental Biology 10 1.45e-01 -2.66e-01 2.47e-01
Disorders of Nervous System Development 10 1.45e-01 -2.66e-01 2.47e-01
Loss of function of MECP2 in Rett syndrome 10 1.45e-01 -2.66e-01 2.47e-01
Pervasive developmental disorders 10 1.45e-01 -2.66e-01 2.47e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 12 1.11e-01 2.66e-01 2.01e-01
NEP/NS2 Interacts with the Cellular Export Machinery 30 1.18e-02 -2.66e-01 3.97e-02
Complex I biogenesis 43 2.59e-03 -2.66e-01 1.19e-02
RAF-independent MAPK1/3 activation 20 4.01e-02 -2.65e-01 1.00e-01
Pausing and recovery of Tat-mediated HIV elongation 26 1.93e-02 -2.65e-01 5.76e-02
Tat-mediated HIV elongation arrest and recovery 26 1.93e-02 -2.65e-01 5.76e-02
EML4 and NUDC in mitotic spindle formation 87 1.97e-05 -2.65e-01 3.20e-04
Defective CFTR causes cystic fibrosis 52 9.58e-04 -2.65e-01 5.38e-03
RNA Polymerase II Pre-transcription Events 68 1.62e-04 -2.65e-01 1.51e-03
Formation of RNA Pol II elongation complex 50 1.25e-03 -2.64e-01 6.64e-03
RNA Polymerase II Transcription Elongation 50 1.25e-03 -2.64e-01 6.64e-03
Degradation of DVL 48 1.58e-03 -2.64e-01 8.15e-03
Other semaphorin interactions 10 1.49e-01 2.63e-01 2.52e-01
BBSome-mediated cargo-targeting to cilium 19 4.69e-02 -2.63e-01 1.11e-01
Nucleotide Excision Repair 99 6.35e-06 -2.63e-01 1.41e-04
Transport of Mature mRNAs Derived from Intronless Transcripts 41 3.62e-03 -2.63e-01 1.52e-02
HCMV Early Events 50 1.32e-03 -2.63e-01 6.97e-03
DNA Double-Strand Break Repair 117 1.01e-06 -2.62e-01 3.48e-05
Regulated Necrosis 43 2.99e-03 -2.62e-01 1.32e-02
Nuclear import of Rev protein 31 1.18e-02 -2.61e-01 3.97e-02
RNA Polymerase III Transcription Termination 21 3.81e-02 -2.61e-01 9.65e-02
Estrogen-dependent gene expression 70 1.58e-04 -2.61e-01 1.51e-03
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 14 9.05e-02 -2.61e-01 1.74e-01
Cellular response to hypoxia 60 4.73e-04 -2.61e-01 3.39e-03
Abortive elongation of HIV-1 transcript in the absence of Tat 22 3.40e-02 -2.61e-01 8.82e-02
Influenza Viral RNA Transcription and Replication 113 1.70e-06 -2.61e-01 5.25e-05
Chaperone Mediated Autophagy 12 1.18e-01 -2.61e-01 2.12e-01
Signaling by NOTCH3 30 1.35e-02 -2.61e-01 4.37e-02
Cyclin D associated events in G1 41 3.96e-03 -2.60e-01 1.63e-02
G1 Phase 41 3.96e-03 -2.60e-01 1.63e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 27 1.99e-02 -2.59e-01 5.88e-02
Dual Incision in GG-NER 35 8.04e-03 -2.59e-01 2.90e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 26 2.24e-02 -2.59e-01 6.40e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 53 1.13e-03 -2.59e-01 6.15e-03
Vitamin B5 (pantothenate) metabolism 11 1.38e-01 -2.58e-01 2.41e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 1.39e-01 -2.58e-01 2.42e-01
Cleavage of the damaged pyrimidine 14 9.55e-02 -2.57e-01 1.79e-01
Depyrimidination 14 9.55e-02 -2.57e-01 1.79e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 14 9.55e-02 -2.57e-01 1.79e-01
Collagen degradation 14 9.56e-02 2.57e-01 1.79e-01
Regulation of PLK1 Activity at G2/M Transition 74 1.37e-04 -2.57e-01 1.37e-03
RHO GTPases Activate Formins 102 7.87e-06 -2.56e-01 1.62e-04
Translation of Structural Proteins 27 2.13e-02 -2.56e-01 6.17e-02
Signaling by FGFR in disease 39 5.68e-03 -2.56e-01 2.19e-02
Activation of gene expression by SREBF (SREBP) 36 8.11e-03 -2.55e-01 2.90e-02
G2/M Checkpoints 119 1.62e-06 -2.55e-01 5.12e-05
Cell Cycle Checkpoints 228 4.47e-11 -2.54e-01 4.89e-09
M Phase 297 7.68e-14 -2.53e-01 1.32e-11
DNA Double Strand Break Response 36 8.69e-03 -2.53e-01 3.06e-02
Mitotic G1 phase and G1/S transition 129 8.07e-07 -2.52e-01 2.94e-05
Host Interactions of HIV factors 106 7.94e-06 -2.51e-01 1.62e-04
tRNA Aminoacylation 23 3.69e-02 -2.51e-01 9.43e-02
G1/S Transition 115 3.34e-06 -2.51e-01 8.92e-05
Formation of a pool of free 40S subunits 78 1.27e-04 -2.51e-01 1.30e-03
mRNA Splicing - Minor Pathway 49 2.41e-03 -2.51e-01 1.12e-02
Class A/1 (Rhodopsin-like receptors) 49 2.42e-03 2.51e-01 1.12e-02
Formation of HIV elongation complex in the absence of HIV Tat 37 8.51e-03 -2.50e-01 3.01e-02
Interleukin-7 signaling 14 1.05e-01 -2.50e-01 1.94e-01
G1/S-Specific Transcription 27 2.48e-02 -2.50e-01 6.87e-02
Transport of Ribonucleoproteins into the Host Nucleus 30 1.80e-02 -2.50e-01 5.46e-02
Nuclear events mediated by NFE2L2 67 4.29e-04 -2.49e-01 3.12e-03
Influenza Infection 130 1.01e-06 -2.49e-01 3.48e-05
Branched-chain amino acid catabolism 20 5.46e-02 -2.48e-01 1.23e-01
Defective Intrinsic Pathway for Apoptosis 23 3.94e-02 -2.48e-01 9.94e-02
Transcription of E2F targets under negative control by DREAM complex 18 6.90e-02 -2.48e-01 1.41e-01
Reproduction 48 3.03e-03 -2.47e-01 1.33e-02
APC-Cdc20 mediated degradation of Nek2A 24 3.62e-02 -2.47e-01 9.27e-02
Telomere C-strand (Lagging Strand) Synthesis 29 2.13e-02 -2.47e-01 6.18e-02
Glucose metabolism 72 2.97e-04 -2.47e-01 2.36e-03
Regulation of expression of SLITs and ROBOs 124 2.18e-06 -2.47e-01 6.38e-05
Downstream signal transduction 20 5.67e-02 -2.46e-01 1.27e-01
RHO GTPases Activate ROCKs 13 1.24e-01 -2.46e-01 2.22e-01
G2/M Transition 156 1.29e-07 -2.46e-01 6.45e-06
Defective pyroptosis 10 1.79e-01 -2.45e-01 2.93e-01
Cap-dependent Translation Initiation 95 3.71e-05 -2.45e-01 4.90e-04
Eukaryotic Translation Initiation 95 3.71e-05 -2.45e-01 4.90e-04
EGFR downregulation 20 5.79e-02 -2.45e-01 1.29e-01
Mitotic G2-G2/M phases 158 1.15e-07 -2.45e-01 6.03e-06
Signaling by FLT3 fusion proteins 16 9.04e-02 -2.44e-01 1.74e-01
Interleukin-15 signaling 11 1.61e-01 -2.44e-01 2.69e-01
S Phase 141 6.15e-07 -2.44e-01 2.41e-05
Transcriptional regulation by small RNAs 45 4.73e-03 -2.43e-01 1.87e-02
Transcription of the HIV genome 57 1.50e-03 -2.43e-01 7.85e-03
Signaling by FGFR2 48 3.64e-03 -2.43e-01 1.52e-02
Fanconi Anemia Pathway 31 1.95e-02 -2.43e-01 5.79e-02
Binding and Uptake of Ligands by Scavenger Receptors 10 1.84e-01 -2.42e-01 2.99e-01
Plasma lipoprotein clearance 24 3.99e-02 -2.42e-01 9.98e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 36 1.20e-02 -2.42e-01 3.98e-02
HIV Transcription Elongation 36 1.20e-02 -2.42e-01 3.98e-02
Tat-mediated elongation of the HIV-1 transcript 36 1.20e-02 -2.42e-01 3.98e-02
CD28 dependent PI3K/Akt signaling 18 7.54e-02 -2.42e-01 1.52e-01
Transcriptional regulation by RUNX3 75 2.96e-04 -2.42e-01 2.36e-03
Peptide chain elongation 69 5.21e-04 -2.42e-01 3.62e-03
Regulation of cholesterol biosynthesis by SREBP (SREBF) 48 4.02e-03 -2.40e-01 1.65e-02
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 35 1.40e-02 -2.40e-01 4.49e-02
Postmitotic nuclear pore complex (NPC) reformation 26 3.42e-02 -2.40e-01 8.83e-02
SUMOylation of ubiquitinylation proteins 37 1.16e-02 -2.40e-01 3.92e-02
Translation 238 2.18e-10 -2.40e-01 1.75e-08
Resolution of D-loop Structures through Holliday Junction Intermediates 28 2.84e-02 -2.39e-01 7.65e-02
Nucleotide salvage 18 7.92e-02 -2.39e-01 1.58e-01
TRAF6 mediated IRF7 activation 16 9.80e-02 -2.39e-01 1.83e-01
Centrosome maturation 66 8.14e-04 -2.38e-01 4.71e-03
Recruitment of mitotic centrosome proteins and complexes 66 8.14e-04 -2.38e-01 4.71e-03
Processing of Intronless Pre-mRNAs 15 1.10e-01 -2.38e-01 2.00e-01
Eukaryotic Translation Termination 72 4.77e-04 -2.38e-01 3.39e-03
ECM proteoglycans 13 1.37e-01 2.38e-01 2.39e-01
ABC transporter disorders 59 1.56e-03 -2.38e-01 8.10e-03
Amyloid fiber formation 27 3.24e-02 -2.38e-01 8.45e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 88 1.17e-04 -2.38e-01 1.23e-03
Nuclear Pore Complex (NPC) Disassembly 34 1.66e-02 -2.37e-01 5.12e-02
G0 and Early G1 24 4.41e-02 -2.37e-01 1.07e-01
Chaperonin-mediated protein folding 57 1.95e-03 -2.37e-01 9.40e-03
Eukaryotic Translation Elongation 72 5.04e-04 -2.37e-01 3.55e-03
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 22 5.41e-02 -2.37e-01 1.22e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 22 5.41e-02 -2.37e-01 1.22e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 22 5.41e-02 -2.37e-01 1.22e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 22 5.41e-02 -2.37e-01 1.22e-01
Impaired BRCA2 binding to PALB2 22 5.41e-02 -2.37e-01 1.22e-01
Apoptotic factor-mediated response 16 1.01e-01 -2.37e-01 1.87e-01
Cell Cycle, Mitotic 425 9.19e-17 -2.37e-01 3.68e-14
APC/C:Cdc20 mediated degradation of Cyclin B 22 5.49e-02 -2.36e-01 1.23e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 58 1.87e-03 -2.36e-01 9.23e-03
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 39 1.07e-02 -2.36e-01 3.68e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 74 4.56e-04 -2.36e-01 3.28e-03
Signaling by ROBO receptors 154 4.71e-07 -2.36e-01 1.95e-05
Selenoamino acid metabolism 78 3.30e-04 -2.35e-01 2.58e-03
Negative regulators of DDX58/IFIH1 signaling 34 1.76e-02 -2.35e-01 5.36e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 8.40e-02 -2.35e-01 1.65e-01
Depolymerisation of the Nuclear Lamina 13 1.42e-01 2.35e-01 2.45e-01
Signaling by FGFR 52 3.39e-03 -2.35e-01 1.45e-02
Formation of the Early Elongation Complex 30 2.61e-02 -2.35e-01 7.18e-02
Formation of the HIV-1 Early Elongation Complex 30 2.61e-02 -2.35e-01 7.18e-02
Metabolism of polyamines 48 5.00e-03 -2.34e-01 1.95e-02
Selenocysteine synthesis 70 7.20e-04 -2.34e-01 4.31e-03
Cilium Assembly 150 8.02e-07 -2.34e-01 2.94e-05
COPI-dependent Golgi-to-ER retrograde traffic 66 1.10e-03 -2.32e-01 6.06e-03
L13a-mediated translational silencing of Ceruloplasmin expression 87 1.84e-04 -2.32e-01 1.61e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 78 3.99e-04 -2.32e-01 3.02e-03
Class I peroxisomal membrane protein import 19 8.01e-02 -2.32e-01 1.59e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 88 1.78e-04 -2.31e-01 1.59e-03
Nonsense-Mediated Decay (NMD) 88 1.78e-04 -2.31e-01 1.59e-03
Transport of the SLBP independent Mature mRNA 33 2.16e-02 -2.31e-01 6.23e-02
Regulation of TP53 Activity 136 3.58e-06 -2.31e-01 9.37e-05
tRNA processing in the nucleus 55 3.19e-03 -2.30e-01 1.40e-02
Interleukin-1 signaling 79 4.15e-04 -2.30e-01 3.07e-03
Viral mRNA Translation 69 9.77e-04 -2.30e-01 5.46e-03
Activation of NF-kappaB in B cells 57 2.74e-03 -2.30e-01 1.23e-02
Keratan sulfate/keratin metabolism 18 9.28e-02 -2.29e-01 1.76e-01
CLEC7A (Dectin-1) induces NFAT activation 11 1.89e-01 -2.29e-01 3.05e-01
Global Genome Nucleotide Excision Repair (GG-NER) 76 5.88e-04 -2.28e-01 3.86e-03
Platelet sensitization by LDL 13 1.55e-01 -2.28e-01 2.62e-01
Formation of Incision Complex in GG-NER 36 1.82e-02 -2.27e-01 5.50e-02
Ub-specific processing proteases 134 6.31e-06 -2.26e-01 1.41e-04
Signaling by cytosolic FGFR1 fusion mutants 16 1.17e-01 -2.26e-01 2.11e-01
Spry regulation of FGF signaling 15 1.30e-01 -2.26e-01 2.31e-01
Transport of the SLBP Dependant Mature mRNA 34 2.33e-02 -2.25e-01 6.56e-02
Smooth Muscle Contraction 19 9.00e-02 -2.25e-01 1.74e-01
NS1 Mediated Effects on Host Pathways 38 1.66e-02 -2.25e-01 5.12e-02
FCERI mediated NF-kB activation 64 1.92e-03 -2.24e-01 9.38e-03
Negative regulation of NMDA receptor-mediated neuronal transmission 12 1.78e-01 2.24e-01 2.92e-01
RHO GTPases activate PAKs 13 1.63e-01 -2.24e-01 2.71e-01
Cell Cycle 530 2.70e-18 -2.23e-01 1.62e-15
DNA Damage Recognition in GG-NER 35 2.23e-02 -2.23e-01 6.38e-02
Processing of Capped Intronless Pre-mRNA 23 6.43e-02 -2.23e-01 1.35e-01
DNA Repair 248 1.87e-09 -2.22e-01 1.32e-07
Post-chaperonin tubulin folding pathway 13 1.67e-01 -2.22e-01 2.76e-01
Regulation of TNFR1 signaling 31 3.30e-02 -2.21e-01 8.58e-02
Assembly of the pre-replicative complex 76 8.74e-04 -2.21e-01 4.98e-03
Metabolism of water-soluble vitamins and cofactors 82 5.67e-04 -2.20e-01 3.79e-03
Inhibition of replication initiation of damaged DNA by RB1/E2F1 10 2.28e-01 -2.20e-01 3.53e-01
CLEC7A (Dectin-1) signaling 84 5.01e-04 -2.20e-01 3.54e-03
Respiratory electron transport 82 5.85e-04 -2.20e-01 3.86e-03
Caspase activation via extrinsic apoptotic signalling pathway 15 1.41e-01 -2.19e-01 2.44e-01
Recognition of DNA damage by PCNA-containing replication complex 26 5.29e-02 -2.19e-01 1.22e-01
Synthesis of DNA 106 1.00e-04 -2.19e-01 1.09e-03
Activation of HOX genes during differentiation 41 1.53e-02 -2.19e-01 4.78e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 41 1.53e-02 -2.19e-01 4.78e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 18 1.08e-01 -2.19e-01 1.99e-01
Apoptosis 133 1.40e-05 -2.19e-01 2.58e-04
Metabolism of cofactors 17 1.19e-01 -2.18e-01 2.14e-01
Gene Silencing by RNA 62 2.99e-03 -2.18e-01 1.32e-02
Glycolysis 57 4.50e-03 -2.18e-01 1.81e-02
Formation of the ternary complex, and subsequently, the 43S complex 40 1.74e-02 -2.17e-01 5.33e-02
Polymerase switching on the C-strand of the telomere 22 7.82e-02 -2.17e-01 1.57e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 1.11e-01 -2.17e-01 2.02e-01
Retrograde transport at the Trans-Golgi-Network 45 1.19e-02 -2.17e-01 3.98e-02
TP53 Regulates Transcription of Cell Cycle Genes 43 1.40e-02 -2.17e-01 4.49e-02
MicroRNA (miRNA) biogenesis 21 8.60e-02 -2.16e-01 1.68e-01
Telomere Maintenance 57 4.78e-03 -2.16e-01 1.89e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 83 6.81e-04 -2.16e-01 4.25e-03
DNA Replication Pre-Initiation 90 4.16e-04 -2.16e-01 3.07e-03
Resolution of D-Loop Structures 29 4.51e-02 -2.15e-01 1.08e-01
tRNA processing 93 3.46e-04 -2.15e-01 2.68e-03
Translocation of SLC2A4 (GLUT4) to the plasma membrane 45 1.31e-02 -2.14e-01 4.26e-02
Transcriptional regulation by RUNX2 84 7.35e-04 -2.13e-01 4.33e-03
Protein folding 63 3.48e-03 -2.13e-01 1.48e-02
Signaling by ALK 18 1.18e-01 -2.13e-01 2.12e-01
Termination of translesion DNA synthesis 28 5.14e-02 -2.13e-01 1.19e-01
Major pathway of rRNA processing in the nucleolus and cytosol 152 6.32e-06 -2.13e-01 1.41e-04
Oncogene Induced Senescence 30 4.39e-02 -2.13e-01 1.07e-01
UCH proteinases 74 1.63e-03 -2.12e-01 8.30e-03
SHC1 events in ERBB2 signaling 11 2.24e-01 2.12e-01 3.48e-01
RHO GTPase Effectors 188 6.20e-07 -2.11e-01 2.41e-05
Organelle biogenesis and maintenance 204 2.17e-07 -2.11e-01 1.00e-05
TBC/RABGAPs 40 2.11e-02 -2.11e-01 6.16e-02
GPCR ligand binding 80 1.16e-03 2.10e-01 6.29e-03
NOTCH4 Intracellular Domain Regulates Transcription 14 1.74e-01 -2.10e-01 2.87e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 41 2.05e-02 -2.09e-01 6.00e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants 41 2.05e-02 -2.09e-01 6.00e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 41 2.05e-02 -2.09e-01 6.00e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer 41 2.05e-02 -2.09e-01 6.00e-02
Signaling by NOTCH1 in Cancer 41 2.05e-02 -2.09e-01 6.00e-02
KEAP1-NFE2L2 pathway 86 8.29e-04 -2.09e-01 4.77e-03
Unwinding of DNA 11 2.31e-01 -2.09e-01 3.55e-01
Orc1 removal from chromatin 62 4.65e-03 -2.08e-01 1.86e-02
ABC-family proteins mediated transport 74 2.06e-03 -2.07e-01 9.86e-03
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 1.09e-01 -2.07e-01 1.99e-01
Neurodegenerative Diseases 20 1.09e-01 -2.07e-01 1.99e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 2.57e-01 -2.07e-01 3.87e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 24 7.98e-02 -2.07e-01 1.59e-01
Chromosome Maintenance 78 1.63e-03 -2.07e-01 8.30e-03
MyD88-independent TLR4 cascade 74 2.18e-03 -2.06e-01 1.03e-02
TRIF(TICAM1)-mediated TLR4 signaling 74 2.18e-03 -2.06e-01 1.03e-02
Switching of origins to a post-replicative state 81 1.35e-03 -2.06e-01 7.09e-03
Hedgehog ‘on’ state 63 4.72e-03 -2.06e-01 1.87e-02
rRNA processing in the nucleus and cytosol 159 7.86e-06 -2.06e-01 1.62e-04
Regulation of mRNA stability by proteins that bind AU-rich elements 77 1.90e-03 -2.05e-01 9.35e-03
Platelet calcium homeostasis 17 1.44e-01 -2.05e-01 2.47e-01
DNA Replication 113 1.78e-04 -2.04e-01 1.59e-03
RMTs methylate histone arginines 25 7.86e-02 -2.03e-01 1.58e-01
Regulation of actin dynamics for phagocytic cup formation 44 1.99e-02 -2.03e-01 5.88e-02
Regulation of IFNA/IFNB signaling 12 2.24e-01 -2.03e-01 3.48e-01
RNA Polymerase III Abortive And Retractive Initiation 39 2.91e-02 -2.02e-01 7.78e-02
RNA Polymerase III Transcription 39 2.91e-02 -2.02e-01 7.78e-02
RIP-mediated NFkB activation via ZBP1 14 1.91e-01 -2.02e-01 3.07e-01
ESR-mediated signaling 115 1.91e-04 -2.02e-01 1.65e-03
Deactivation of the beta-catenin transactivating complex 28 6.49e-02 -2.02e-01 1.36e-01
Downstream TCR signaling 71 3.37e-03 -2.01e-01 1.45e-02
Diseases associated with glycosylation precursor biosynthesis 15 1.79e-01 -2.00e-01 2.92e-01
Signaling by EGFR 35 4.07e-02 -2.00e-01 1.01e-01
Downstream signaling events of B Cell Receptor (BCR) 70 3.94e-03 -1.99e-01 1.63e-02
TRAF3-dependent IRF activation pathway 14 1.97e-01 -1.99e-01 3.14e-01
Processing of Capped Intron-Containing Pre-mRNA 199 1.41e-06 -1.99e-01 4.70e-05
Metabolism of vitamins and cofactors 111 3.11e-04 -1.98e-01 2.44e-03
CD28 co-stimulation 27 7.44e-02 -1.98e-01 1.50e-01
mRNA Splicing - Major Pathway 148 3.32e-05 -1.98e-01 4.64e-04
Signaling by KIT in disease 16 1.71e-01 -1.98e-01 2.81e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 16 1.71e-01 -1.98e-01 2.81e-01
EPHB-mediated forward signaling 25 8.69e-02 -1.98e-01 1.69e-01
Transcriptional Regulation by E2F6 29 6.55e-02 -1.98e-01 1.37e-01
Kinesins 32 5.33e-02 -1.97e-01 1.22e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 1.38e-01 -1.97e-01 2.41e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 1.38e-01 -1.97e-01 2.41e-01
rRNA processing 164 1.50e-05 -1.96e-01 2.73e-04
Glutathione conjugation 21 1.20e-01 -1.96e-01 2.15e-01
SUMOylation of immune response proteins 10 2.84e-01 -1.96e-01 4.18e-01
Glycosphingolipid metabolism 27 7.86e-02 -1.96e-01 1.58e-01
Hedgehog ‘off’ state 75 3.43e-03 -1.96e-01 1.46e-02
mRNA Splicing 158 2.47e-05 -1.95e-01 3.90e-04
Programmed Cell Death 155 3.05e-05 -1.95e-01 4.31e-04
NOTCH3 Intracellular Domain Regulates Transcription 15 1.92e-01 -1.95e-01 3.08e-01
HIV Infection 190 4.14e-06 -1.94e-01 1.06e-04
SUMOylation of DNA damage response and repair proteins 67 6.15e-03 -1.94e-01 2.33e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 35 4.77e-02 -1.93e-01 1.12e-01
Toll Like Receptor 4 (TLR4) Cascade 94 1.22e-03 -1.93e-01 6.57e-03
Mitochondrial translation 89 1.66e-03 -1.93e-01 8.43e-03
Metabolism of RNA 553 1.47e-14 -1.93e-01 2.95e-12
Pyruvate metabolism 20 1.35e-01 -1.93e-01 2.37e-01
HDMs demethylate histones 15 1.96e-01 -1.93e-01 3.13e-01
Aggrephagy 19 1.46e-01 -1.93e-01 2.48e-01
Signaling by Nuclear Receptors 151 4.71e-05 -1.92e-01 5.89e-04
Negative regulation of MAPK pathway 36 4.62e-02 -1.92e-01 1.10e-01
ABC transporters in lipid homeostasis 10 2.94e-01 1.92e-01 4.29e-01
RHOQ GTPase cycle 39 3.87e-02 1.91e-01 9.78e-02
Nuclear Receptor transcription pathway 27 8.62e-02 -1.91e-01 1.68e-01
FLT3 Signaling 32 6.23e-02 -1.90e-01 1.34e-01
Drug ADME 27 8.69e-02 -1.90e-01 1.69e-01
Late Phase of HIV Life Cycle 117 3.85e-04 -1.90e-01 2.95e-03
Deubiquitination 198 4.35e-06 -1.90e-01 1.09e-04
Signaling by FGFR3 26 9.39e-02 -1.90e-01 1.78e-01
Negative epigenetic regulation of rRNA expression 44 2.97e-02 -1.90e-01 7.91e-02
ERK/MAPK targets 16 1.90e-01 -1.89e-01 3.06e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 16 1.90e-01 -1.89e-01 3.07e-01
PCP/CE pathway 71 6.04e-03 -1.89e-01 2.30e-02
RNA polymerase II transcribes snRNA genes 71 6.12e-03 -1.88e-01 2.33e-02
Toll Like Receptor 3 (TLR3) Cascade 74 5.46e-03 -1.87e-01 2.11e-02
Golgi-to-ER retrograde transport 95 1.70e-03 -1.87e-01 8.56e-03
SUMOylation of DNA methylation proteins 14 2.27e-01 1.86e-01 3.53e-01
Mitochondrial translation termination 83 3.39e-03 -1.86e-01 1.45e-02
GPVI-mediated activation cascade 23 1.23e-01 -1.86e-01 2.20e-01
HIV Life Cycle 129 2.81e-04 -1.86e-01 2.27e-03
PERK regulates gene expression 26 1.02e-01 -1.85e-01 1.89e-01
Signaling by the B Cell Receptor (BCR) 90 2.42e-03 -1.85e-01 1.12e-02
NoRC negatively regulates rRNA expression 42 3.87e-02 -1.84e-01 9.78e-02
SUMO E3 ligases SUMOylate target proteins 132 2.70e-04 -1.84e-01 2.19e-03
Azathioprine ADME 15 2.17e-01 -1.84e-01 3.40e-01
C-type lectin receptors (CLRs) 100 1.55e-03 -1.83e-01 8.04e-03
Triglyceride catabolism 11 2.92e-01 -1.83e-01 4.27e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 2.53e-01 -1.83e-01 3.82e-01
Translation initiation complex formation 47 3.00e-02 -1.83e-01 7.95e-02
Ribosomal scanning and start codon recognition 47 3.01e-02 -1.83e-01 7.98e-02
Ion homeostasis 26 1.07e-01 -1.83e-01 1.96e-01
Cargo trafficking to the periciliary membrane 40 4.55e-02 -1.83e-01 1.09e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 35 6.25e-02 1.82e-01 1.34e-01
Transcriptional Regulation by TP53 302 6.55e-08 -1.82e-01 3.58e-06
Diseases associated with glycosaminoglycan metabolism 16 2.09e-01 -1.82e-01 3.29e-01
Downstream signaling of activated FGFR1 12 2.76e-01 -1.81e-01 4.09e-01
Downstream signaling of activated FGFR2 12 2.76e-01 -1.81e-01 4.09e-01
Downstream signaling of activated FGFR3 12 2.76e-01 -1.81e-01 4.09e-01
Downstream signaling of activated FGFR4 12 2.76e-01 -1.81e-01 4.09e-01
Phosphorylation of the APC/C 18 1.83e-01 -1.81e-01 2.98e-01
The citric acid (TCA) cycle and respiratory electron transport 121 5.91e-04 -1.81e-01 3.86e-03
Molecules associated with elastic fibres 12 2.78e-01 1.81e-01 4.11e-01
Infection with Mycobacterium tuberculosis 22 1.42e-01 -1.81e-01 2.45e-01
E3 ubiquitin ligases ubiquitinate target proteins 41 4.57e-02 -1.80e-01 1.09e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 158 9.69e-05 -1.80e-01 1.09e-03
Regulation of pyruvate dehydrogenase (PDH) complex 11 3.01e-01 -1.80e-01 4.36e-01
MHC class II antigen presentation 69 9.88e-03 -1.80e-01 3.43e-02
Selective autophagy 50 2.82e-02 -1.79e-01 7.65e-02
Arachidonic acid metabolism 21 1.55e-01 1.79e-01 2.61e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 14 2.46e-01 -1.79e-01 3.73e-01
Mitochondrial translation initiation 84 4.69e-03 -1.79e-01 1.86e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 8.07e-02 -1.78e-01 1.60e-01
SARS-CoV-1 Infection 46 3.69e-02 -1.78e-01 9.43e-02
Other interleukin signaling 15 2.33e-01 -1.78e-01 3.57e-01
Mitochondrial Fatty Acid Beta-Oxidation 26 1.17e-01 -1.78e-01 2.10e-01
TNF signaling 38 5.84e-02 -1.78e-01 1.29e-01
ATF4 activates genes in response to endoplasmic reticulum stress 23 1.41e-01 -1.77e-01 2.44e-01
SUMOylation of intracellular receptors 19 1.81e-01 -1.77e-01 2.95e-01
NOTCH1 Intracellular Domain Regulates Transcription 37 6.25e-02 -1.77e-01 1.34e-01
Transport of Mature Transcript to Cytoplasm 64 1.45e-02 -1.77e-01 4.60e-02
Nuclear Envelope (NE) Reassembly 60 1.86e-02 -1.76e-01 5.60e-02
Meiotic synapsis 25 1.29e-01 -1.76e-01 2.28e-01
Regulation of PTEN mRNA translation 11 3.13e-01 1.76e-01 4.50e-01
Epigenetic regulation of gene expression 76 8.24e-03 -1.75e-01 2.93e-02
Deposition of new CENPA-containing nucleosomes at the centromere 23 1.45e-01 -1.75e-01 2.47e-01
Nucleosome assembly 23 1.45e-01 -1.75e-01 2.47e-01
mRNA decay by 3’ to 5’ exoribonuclease 14 2.56e-01 -1.75e-01 3.85e-01
SUMOylation 138 3.96e-04 -1.75e-01 3.01e-03
Cellular Senescence 106 1.94e-03 -1.75e-01 9.40e-03
Signaling by TGF-beta Receptor Complex 72 1.05e-02 -1.74e-01 3.63e-02
SUMOylation of DNA replication proteins 43 4.80e-02 -1.74e-01 1.12e-01
RHOJ GTPase cycle 37 6.69e-02 1.74e-01 1.39e-01
Deadenylation-dependent mRNA decay 52 3.03e-02 -1.74e-01 7.98e-02
Nucleotide biosynthesis 12 2.98e-01 -1.73e-01 4.34e-01
Protein localization 123 9.50e-04 -1.73e-01 5.36e-03
Plasma lipoprotein assembly, remodeling, and clearance 39 6.31e-02 -1.72e-01 1.34e-01
PRC2 methylates histones and DNA 12 3.02e-01 -1.72e-01 4.37e-01
Signaling by Erythropoietin 19 1.96e-01 -1.71e-01 3.13e-01
Signaling by FGFR4 25 1.38e-01 -1.71e-01 2.41e-01
Activated NOTCH1 Transmits Signal to the Nucleus 19 1.97e-01 -1.71e-01 3.14e-01
Inflammasomes 16 2.37e-01 -1.71e-01 3.63e-01
Phase II - Conjugation of compounds 46 4.55e-02 -1.71e-01 1.09e-01
Signalling to RAS 12 3.08e-01 -1.70e-01 4.43e-01
G alpha (z) signalling events 25 1.41e-01 1.70e-01 2.44e-01
Fc epsilon receptor (FCERI) signaling 107 2.45e-03 -1.70e-01 1.13e-02
Mitotic Prophase 75 1.12e-02 -1.70e-01 3.81e-02
ADP signalling through P2Y purinoceptor 1 16 2.41e-01 1.69e-01 3.67e-01
Regulation of HSF1-mediated heat shock response 67 1.69e-02 -1.69e-01 5.22e-02
Signaling by NOTCH 135 7.28e-04 -1.69e-01 4.33e-03
RNA Polymerase III Chain Elongation 17 2.28e-01 -1.69e-01 3.53e-01
RORA activates gene expression 11 3.34e-01 -1.68e-01 4.68e-01
Initiation of Nuclear Envelope (NE) Reformation 17 2.31e-01 -1.68e-01 3.55e-01
Mitochondrial translation elongation 84 8.07e-03 -1.67e-01 2.90e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 48 4.53e-02 -1.67e-01 1.08e-01
mTORC1-mediated signalling 21 1.85e-01 1.67e-01 3.00e-01
Metabolism of carbohydrates 181 1.17e-04 -1.67e-01 1.23e-03
Factors involved in megakaryocyte development and platelet production 87 7.36e-03 -1.66e-01 2.72e-02
PTEN Regulation 115 2.09e-03 -1.66e-01 9.97e-03
Metabolism of amino acids and derivatives 225 2.01e-05 -1.66e-01 3.22e-04
DAP12 signaling 19 2.12e-01 -1.66e-01 3.34e-01
DNA Damage Bypass 42 6.53e-02 -1.64e-01 1.37e-01
PINK1-PRKN Mediated Mitophagy 20 2.04e-01 -1.64e-01 3.23e-01
Fcgamma receptor (FCGR) dependent phagocytosis 62 2.56e-02 -1.64e-01 7.07e-02
Disorders of transmembrane transporters 111 2.89e-03 -1.64e-01 1.29e-02
Cellular response to chemical stress 145 6.94e-04 -1.64e-01 4.25e-03
COPI-mediated anterograde transport 71 1.74e-02 -1.63e-01 5.32e-02
Interleukin-6 family signaling 13 3.08e-01 -1.63e-01 4.43e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 10 3.73e-01 -1.63e-01 5.14e-01
Assembly of collagen fibrils and other multimeric structures 14 2.92e-01 1.63e-01 4.26e-01
STING mediated induction of host immune responses 10 3.74e-01 1.62e-01 5.14e-01
Mitochondrial iron-sulfur cluster biogenesis 12 3.31e-01 -1.62e-01 4.66e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 88 9.11e-03 -1.61e-01 3.18e-02
Diseases of signal transduction by growth factor receptors and second messengers 299 1.89e-06 -1.61e-01 5.69e-05
Disease 1086 1.75e-18 -1.61e-01 1.62e-15
Endosomal/Vacuolar pathway 10 3.81e-01 -1.60e-01 5.18e-01
Cell-cell junction organization 13 3.19e-01 1.60e-01 4.54e-01
SARS-CoV-2-host interactions 150 7.57e-04 -1.60e-01 4.44e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript 55 4.13e-02 -1.59e-01 1.02e-01
Metabolism of non-coding RNA 48 5.72e-02 -1.59e-01 1.27e-01
snRNP Assembly 48 5.72e-02 -1.59e-01 1.27e-01
RHOF GTPase cycle 25 1.70e-01 1.59e-01 2.81e-01
Interleukin-1 family signaling 99 6.62e-03 -1.58e-01 2.47e-02
Post-translational protein phosphorylation 34 1.11e-01 1.58e-01 2.01e-01
Intrinsic Pathway for Apoptosis 47 6.16e-02 -1.58e-01 1.34e-01
Signaling by ERBB2 KD Mutants 12 3.45e-01 -1.57e-01 4.80e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 29 1.43e-01 -1.57e-01 2.45e-01
ZBP1(DAI) mediated induction of type I IFNs 17 2.64e-01 -1.56e-01 3.97e-01
N-Glycan antennae elongation 10 3.92e-01 -1.56e-01 5.29e-01
FCGR3A-mediated phagocytosis 42 8.10e-02 -1.56e-01 1.60e-01
Leishmania phagocytosis 42 8.10e-02 -1.56e-01 1.60e-01
Parasite infection 42 8.10e-02 -1.56e-01 1.60e-01
Diseases of metabolism 126 2.60e-03 -1.56e-01 1.19e-02
Ion transport by P-type ATPases 27 1.62e-01 -1.56e-01 2.70e-01
Cellular response to heat stress 80 1.63e-02 -1.56e-01 5.05e-02
MyD88 dependent cascade initiated on endosome 67 2.80e-02 -1.55e-01 7.61e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade 67 2.80e-02 -1.55e-01 7.61e-02
G-protein activation 13 3.32e-01 1.55e-01 4.67e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 14 3.18e-01 -1.54e-01 4.54e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 16 2.87e-01 -1.54e-01 4.21e-01
ISG15 antiviral mechanism 70 2.63e-02 -1.54e-01 7.22e-02
SUMOylation of RNA binding proteins 42 8.57e-02 -1.53e-01 1.68e-01
Response of Mtb to phagocytosis 20 2.36e-01 -1.53e-01 3.61e-01
Interleukin-12 family signaling 42 8.69e-02 -1.53e-01 1.69e-01
Regulation of TP53 Activity through Methylation 17 2.76e-01 -1.52e-01 4.09e-01
Generic Transcription Pathway 826 2.26e-13 -1.52e-01 3.40e-11
TCF dependent signaling in response to WNT 119 4.28e-03 -1.52e-01 1.73e-02
SUMOylation of transcription factors 13 3.43e-01 -1.52e-01 4.79e-01
Cytochrome P450 - arranged by substrate type 14 3.26e-01 1.52e-01 4.61e-01
Peroxisomal protein import 48 6.92e-02 -1.52e-01 1.41e-01
Elevation of cytosolic Ca2+ levels 10 4.07e-01 -1.52e-01 5.42e-01
Gene expression (Transcription) 1040 5.39e-16 -1.52e-01 1.62e-13
p75 NTR receptor-mediated signalling 59 4.44e-02 -1.51e-01 1.07e-01
EPH-Ephrin signaling 55 5.24e-02 -1.51e-01 1.21e-01
Toll-like Receptor Cascades 108 6.85e-03 -1.51e-01 2.54e-02
Apoptotic execution phase 33 1.35e-01 -1.50e-01 2.37e-01
Signaling by MET 41 9.63e-02 -1.50e-01 1.80e-01
RNA Polymerase III Transcription Initiation 35 1.24e-01 -1.50e-01 2.22e-01
Calnexin/calreticulin cycle 23 2.13e-01 -1.50e-01 3.34e-01
Signaling by FGFR1 28 1.70e-01 -1.50e-01 2.81e-01
Signaling by NOTCH1 51 6.47e-02 -1.50e-01 1.36e-01
Signaling by PDGF 25 1.98e-01 -1.49e-01 3.15e-01
Cellular response to starvation 120 4.98e-03 -1.49e-01 1.95e-02
Cholesterol biosynthesis 22 2.28e-01 -1.49e-01 3.53e-01
Neddylation 188 5.38e-04 -1.47e-01 3.70e-03
Rap1 signalling 11 4.00e-01 -1.47e-01 5.35e-01
Extension of Telomeres 44 9.41e-02 -1.46e-01 1.78e-01
Signaling by ERBB4 31 1.60e-01 -1.46e-01 2.69e-01
Heme signaling 26 1.99e-01 -1.45e-01 3.17e-01
Synthesis of IP3 and IP4 in the cytosol 16 3.15e-01 -1.45e-01 4.51e-01
Nuclear Events (kinase and transcription factor activation) 42 1.05e-01 -1.45e-01 1.93e-01
Phase I - Functionalization of compounds 30 1.70e-01 1.45e-01 2.81e-01
Nucleotide catabolism 21 2.51e-01 -1.45e-01 3.79e-01
Hyaluronan uptake and degradation 10 4.28e-01 -1.45e-01 5.64e-01
Mitochondrial protein import 48 8.31e-02 -1.45e-01 1.63e-01
Signaling by Non-Receptor Tyrosine Kinases 36 1.33e-01 -1.45e-01 2.35e-01
Signaling by PTK6 36 1.33e-01 -1.45e-01 2.35e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 66 4.29e-02 -1.44e-01 1.05e-01
Signaling by SCF-KIT 32 1.58e-01 -1.44e-01 2.66e-01
Death Receptor Signalling 96 1.52e-02 -1.44e-01 4.77e-02
Prostacyclin signalling through prostacyclin receptor 12 3.89e-01 1.44e-01 5.27e-01
Mitochondrial biogenesis 54 6.88e-02 -1.43e-01 1.41e-01
Cargo recognition for clathrin-mediated endocytosis 63 4.94e-02 -1.43e-01 1.15e-01
RNA Polymerase II Transcription 927 4.53e-13 -1.43e-01 6.04e-11
Cargo concentration in the ER 20 2.70e-01 -1.43e-01 4.04e-01
Transcriptional Regulation by VENTX 30 1.78e-01 -1.42e-01 2.91e-01
Activation of ATR in response to replication stress 36 1.40e-01 -1.42e-01 2.43e-01
Nicotinamide salvaging 11 4.15e-01 1.42e-01 5.49e-01
Infectious disease 627 1.97e-09 -1.42e-01 1.32e-07
MyD88 cascade initiated on plasma membrane 65 4.83e-02 -1.42e-01 1.12e-01
Toll Like Receptor 10 (TLR10) Cascade 65 4.83e-02 -1.42e-01 1.12e-01
Toll Like Receptor 5 (TLR5) Cascade 65 4.83e-02 -1.42e-01 1.12e-01
TCR signaling 87 2.26e-02 -1.42e-01 6.40e-02
Toll Like Receptor 9 (TLR9) Cascade 70 4.09e-02 -1.41e-01 1.01e-01
Cell junction organization 26 2.12e-01 1.41e-01 3.34e-01
Metabolism of nucleotides 73 3.72e-02 -1.41e-01 9.45e-02
Apoptotic cleavage of cellular proteins 25 2.22e-01 -1.41e-01 3.47e-01
Cytoprotection by HMOX1 44 1.06e-01 -1.41e-01 1.95e-01
MAPK1/MAPK3 signaling 164 1.91e-03 -1.41e-01 9.35e-03
SARS-CoV-2 Infection 213 4.15e-04 -1.41e-01 3.07e-03
HCMV Infection 71 4.06e-02 -1.41e-01 1.01e-01
Nonhomologous End-Joining (NHEJ) 29 1.91e-01 -1.40e-01 3.07e-01
MAPK family signaling cascades 191 8.72e-04 -1.40e-01 4.98e-03
Nuclear Envelope Breakdown 49 9.08e-02 -1.40e-01 1.75e-01
TNFR2 non-canonical NF-kB pathway 68 4.67e-02 -1.40e-01 1.11e-01
RHOD GTPase cycle 36 1.48e-01 1.39e-01 2.50e-01
Class I MHC mediated antigen processing & presentation 289 5.00e-05 -1.39e-01 6.13e-04
Aquaporin-mediated transport 25 2.29e-01 1.39e-01 3.53e-01
Interleukin-37 signaling 17 3.21e-01 1.39e-01 4.57e-01
tRNA modification in the nucleus and cytosol 34 1.61e-01 -1.39e-01 2.70e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 23 2.50e-01 -1.39e-01 3.78e-01
Diseases of glycosylation 69 4.76e-02 -1.38e-01 1.12e-01
HATs acetylate histones 63 5.86e-02 -1.38e-01 1.29e-01
Inwardly rectifying K+ channels 13 3.90e-01 1.38e-01 5.27e-01
Metabolism of proteins 1246 1.59e-15 -1.37e-01 3.82e-13
Cellular responses to stress 546 5.40e-08 -1.37e-01 3.09e-06
Cellular responses to stimuli 551 4.86e-08 -1.37e-01 2.92e-06
FGFR1 mutant receptor activation 20 2.89e-01 -1.37e-01 4.23e-01
Signaling by FGFR1 in disease 24 2.46e-01 -1.37e-01 3.73e-01
Negative regulation of FGFR1 signaling 18 3.19e-01 -1.36e-01 4.54e-01
Negative regulation of FGFR2 signaling 18 3.19e-01 -1.36e-01 4.54e-01
Negative regulation of FGFR3 signaling 18 3.19e-01 -1.36e-01 4.54e-01
Negative regulation of FGFR4 signaling 18 3.19e-01 -1.36e-01 4.54e-01
Interleukin-4 and Interleukin-13 signaling 49 1.01e-01 -1.36e-01 1.87e-01
Mitophagy 25 2.42e-01 -1.35e-01 3.69e-01
HDACs deacetylate histones 28 2.17e-01 -1.35e-01 3.39e-01
Metabolism of porphyrins 15 3.67e-01 -1.35e-01 5.06e-01
Signaling by Hedgehog 99 2.12e-02 -1.34e-01 6.16e-02
Signaling by BMP 15 3.68e-01 1.34e-01 5.08e-01
Asparagine N-linked glycosylation 225 5.68e-04 -1.34e-01 3.79e-03
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 21 2.91e-01 -1.33e-01 4.26e-01
Cytochrome c-mediated apoptotic response 11 4.47e-01 -1.32e-01 5.83e-01
Degradation of the extracellular matrix 35 1.78e-01 1.32e-01 2.91e-01
A tetrasaccharide linker sequence is required for GAG synthesis 10 4.71e-01 1.32e-01 6.01e-01
Constitutive Signaling by AKT1 E17K in Cancer 23 2.75e-01 -1.31e-01 4.09e-01
G alpha (i) signalling events 93 2.93e-02 1.31e-01 7.83e-02
ER to Golgi Anterograde Transport 108 1.90e-02 -1.31e-01 5.70e-02
Non-integrin membrane-ECM interactions 14 3.97e-01 1.31e-01 5.33e-01
Circadian Clock 52 1.03e-01 -1.31e-01 1.91e-01
Condensation of Prophase Chromosomes 12 4.38e-01 -1.29e-01 5.75e-01
Antigen processing: Ubiquitination & Proteasome degradation 241 5.86e-04 -1.29e-01 3.86e-03
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 33 2.00e-01 -1.29e-01 3.17e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 41 1.53e-01 -1.29e-01 2.58e-01
Listeria monocytogenes entry into host cells 14 4.07e-01 -1.28e-01 5.42e-01
Beta-catenin independent WNT signaling 106 2.34e-02 -1.28e-01 6.58e-02
G alpha (s) signalling events 48 1.28e-01 1.27e-01 2.27e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 12 4.46e-01 1.27e-01 5.83e-01
Trafficking of AMPA receptors 12 4.46e-01 1.27e-01 5.83e-01
VEGFA-VEGFR2 Pathway 71 6.42e-02 -1.27e-01 1.35e-01
Antiviral mechanism by IFN-stimulated genes 77 5.40e-02 -1.27e-01 1.22e-01
Transcriptional regulation of white adipocyte differentiation 56 1.01e-01 -1.27e-01 1.87e-01
Metabolism of steroids 86 4.21e-02 -1.27e-01 1.04e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 10 4.87e-01 -1.27e-01 6.13e-01
Generation of second messenger molecules 15 3.96e-01 1.27e-01 5.32e-01
Hyaluronan metabolism 11 4.68e-01 -1.26e-01 5.99e-01
Triglyceride metabolism 16 3.82e-01 -1.26e-01 5.19e-01
Interleukin receptor SHC signaling 15 3.99e-01 -1.26e-01 5.34e-01
G alpha (q) signalling events 78 5.59e-02 1.25e-01 1.25e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 61 9.10e-02 -1.25e-01 1.75e-01
Downregulation of TGF-beta receptor signaling 26 2.70e-01 -1.25e-01 4.04e-01
GAB1 signalosome 10 4.94e-01 -1.25e-01 6.20e-01
Signaling by Activin 12 4.54e-01 1.25e-01 5.86e-01
Activation of G protein gated Potassium channels 12 4.55e-01 1.25e-01 5.86e-01
G protein gated Potassium channels 12 4.55e-01 1.25e-01 5.86e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 12 4.55e-01 1.25e-01 5.86e-01
Signaling by TGFB family members 85 4.75e-02 -1.25e-01 1.12e-01
Signaling by WNT 177 4.46e-03 -1.24e-01 1.80e-02
Regulation of beta-cell development 16 3.90e-01 -1.24e-01 5.27e-01
DAP12 interactions 21 3.29e-01 -1.23e-01 4.65e-01
RAF/MAP kinase cascade 159 7.62e-03 -1.23e-01 2.79e-02
DCC mediated attractive signaling 11 4.81e-01 1.23e-01 6.08e-01
The NLRP3 inflammasome 12 4.64e-01 -1.22e-01 5.95e-01
SARS-CoV-2 modulates host translation machinery 39 1.88e-01 -1.22e-01 3.04e-01
GPCR downstream signalling 197 3.26e-03 1.22e-01 1.42e-02
Sphingolipid de novo biosynthesis 22 3.24e-01 1.21e-01 4.60e-01
PIP3 activates AKT signaling 185 4.56e-03 -1.21e-01 1.83e-02
SARS-CoV Infections 270 6.53e-04 -1.21e-01 4.17e-03
Downregulation of SMAD2/3:SMAD4 transcriptional activity 24 3.06e-01 -1.21e-01 4.42e-01
Vesicle-mediated transport 454 1.24e-05 -1.21e-01 2.41e-04
Interleukin-12 signaling 36 2.11e-01 -1.20e-01 3.33e-01
Downregulation of ERBB2:ERBB3 signaling 10 5.10e-01 -1.20e-01 6.35e-01
Transport to the Golgi and subsequent modification 130 1.85e-02 -1.20e-01 5.58e-02
Transcriptional regulation of granulopoiesis 25 3.00e-01 -1.20e-01 4.35e-01
Role of phospholipids in phagocytosis 16 4.07e-01 -1.20e-01 5.42e-01
Metabolism 1253 4.14e-12 -1.19e-01 4.98e-10
Axon guidance 300 4.31e-04 -1.19e-01 3.12e-03
Response to elevated platelet cytosolic Ca2+ 53 1.36e-01 -1.19e-01 2.37e-01
Protein methylation 14 4.46e-01 1.18e-01 5.83e-01
Signaling by Leptin 10 5.20e-01 -1.17e-01 6.44e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 29 2.75e-01 -1.17e-01 4.09e-01
Caspase-mediated cleavage of cytoskeletal proteins 10 5.21e-01 -1.17e-01 6.44e-01
Membrane Trafficking 446 2.62e-05 -1.17e-01 4.09e-04
Erythropoietin activates RAS 10 5.22e-01 -1.17e-01 6.45e-01
Gap junction trafficking and regulation 11 5.02e-01 1.17e-01 6.28e-01
Extracellular matrix organization 93 5.18e-02 1.17e-01 1.20e-01
SUMOylation of chromatin organization proteins 49 1.57e-01 -1.17e-01 2.65e-01
Regulation of TP53 Activity through Acetylation 27 2.96e-01 -1.16e-01 4.30e-01
Gastrin-CREB signalling pathway via PKC and MAPK 11 5.05e-01 -1.16e-01 6.30e-01
Post-translational modification: synthesis of GPI-anchored proteins 31 2.63e-01 -1.16e-01 3.96e-01
Platelet degranulation 49 1.62e-01 -1.16e-01 2.70e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 71 9.25e-02 -1.16e-01 1.76e-01
Toll Like Receptor 2 (TLR2) Cascade 71 9.25e-02 -1.16e-01 1.76e-01
Toll Like Receptor TLR1:TLR2 Cascade 71 9.25e-02 -1.16e-01 1.76e-01
Toll Like Receptor TLR6:TLR2 Cascade 71 9.25e-02 -1.16e-01 1.76e-01
FOXO-mediated transcription of cell death genes 14 4.54e-01 -1.15e-01 5.86e-01
TNFR1-induced NFkappaB signaling pathway 20 3.73e-01 -1.15e-01 5.14e-01
Nervous system development 313 5.10e-04 -1.15e-01 3.56e-03
Class B/2 (Secretin family receptors) 29 2.85e-01 1.15e-01 4.19e-01
Signaling by VEGF 73 9.12e-02 -1.14e-01 1.75e-01
Signaling by GPCR 216 4.05e-03 1.14e-01 1.65e-02
Clathrin-mediated endocytosis 89 6.38e-02 -1.14e-01 1.35e-01
Collagen biosynthesis and modifying enzymes 19 3.93e-01 1.13e-01 5.30e-01
Intracellular signaling by second messengers 210 4.89e-03 -1.13e-01 1.92e-02
RAS processing 15 4.51e-01 -1.12e-01 5.86e-01
Signaling by Interleukins 265 1.73e-03 -1.12e-01 8.65e-03
Synthesis of very long-chain fatty acyl-CoAs 16 4.37e-01 1.12e-01 5.74e-01
The phototransduction cascade 18 4.11e-01 1.12e-01 5.46e-01
PI3K Cascade 19 3.99e-01 1.12e-01 5.34e-01
Signaling by Receptor Tyrosine Kinases 293 1.07e-03 -1.12e-01 5.92e-03
Activation of kainate receptors upon glutamate binding 17 4.27e-01 1.11e-01 5.63e-01
Post-translational protein modification 917 2.04e-08 -1.11e-01 1.29e-06
Thrombin signalling through proteinase activated receptors (PARs) 20 3.90e-01 1.11e-01 5.27e-01
VEGFR2 mediated vascular permeability 21 3.79e-01 -1.11e-01 5.18e-01
Signaling by WNT in cancer 23 3.59e-01 -1.11e-01 4.98e-01
Interferon Signaling 142 2.35e-02 -1.10e-01 6.60e-02
MAPK targets/ Nuclear events mediated by MAP kinases 23 3.60e-01 -1.10e-01 4.99e-01
NGF-stimulated transcription 25 3.40e-01 -1.10e-01 4.76e-01
Josephin domain DUBs 11 5.28e-01 -1.10e-01 6.48e-01
Regulation of signaling by CBL 14 4.78e-01 -1.10e-01 6.05e-01
G-protein mediated events 32 2.84e-01 -1.10e-01 4.18e-01
RAC3 GTPase cycle 59 1.46e-01 1.09e-01 2.48e-01
Adaptive Immune System 481 4.80e-05 -1.09e-01 5.94e-04
EPH-ephrin mediated repulsion of cells 25 3.51e-01 -1.08e-01 4.88e-01
Zinc transporters 12 5.18e-01 -1.08e-01 6.42e-01
TP53 Regulates Metabolic Genes 71 1.19e-01 -1.07e-01 2.13e-01
Intra-Golgi traffic 39 2.51e-01 -1.06e-01 3.79e-01
Developmental Biology 468 9.95e-05 -1.06e-01 1.09e-03
Regulation of RUNX1 Expression and Activity 17 4.54e-01 -1.05e-01 5.86e-01
Protein ubiquitination 59 1.66e-01 -1.04e-01 2.75e-01
Costimulation by the CD28 family 44 2.31e-01 -1.04e-01 3.55e-01
Chromatin modifying enzymes 158 2.40e-02 -1.04e-01 6.69e-02
Chromatin organization 158 2.40e-02 -1.04e-01 6.69e-02
Cytosolic sensors of pathogen-associated DNA 53 1.90e-01 -1.04e-01 3.06e-01
Signaling by NODAL 12 5.32e-01 1.04e-01 6.50e-01
Extra-nuclear estrogen signaling 49 2.08e-01 -1.04e-01 3.29e-01
Signaling by Rho GTPases 437 2.18e-04 -1.04e-01 1.80e-03
Cell death signalling via NRAGE, NRIF and NADE 45 2.29e-01 -1.04e-01 3.53e-01
Bile acid and bile salt metabolism 15 4.87e-01 1.04e-01 6.13e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 449 1.93e-04 -1.03e-01 1.66e-03
Fatty acyl-CoA biosynthesis 26 3.62e-01 -1.03e-01 5.01e-01
Regulation of PTEN gene transcription 48 2.17e-01 -1.03e-01 3.39e-01
Metabolism of steroid hormones 13 5.23e-01 -1.02e-01 6.45e-01
KSRP (KHSRP) binds and destabilizes mRNA 15 4.94e-01 -1.02e-01 6.20e-01
Role of LAT2/NTAL/LAB on calcium mobilization 10 5.78e-01 -1.02e-01 6.87e-01
Signaling by NTRK3 (TRKC) 11 5.63e-01 -1.01e-01 6.76e-01
Formation of the beta-catenin:TCF transactivating complex 25 3.84e-01 -1.01e-01 5.22e-01
COPII-mediated vesicle transport 51 2.15e-01 -1.00e-01 3.38e-01
Cytokine Signaling in Immune system 427 4.27e-04 -1.00e-01 3.12e-03
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 23 4.08e-01 9.98e-02 5.42e-01
TP53 Regulates Transcription of Cell Death Genes 31 3.37e-01 -9.98e-02 4.71e-01
Stimuli-sensing channels 39 2.82e-01 9.96e-02 4.16e-01
Signal transduction by L1 11 5.72e-01 -9.84e-02 6.82e-01
Signaling by Hippo 12 5.55e-01 -9.83e-02 6.71e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 16 4.97e-01 -9.81e-02 6.23e-01
RHOBTB GTPase Cycle 29 3.62e-01 -9.79e-02 5.01e-01
Nephrin family interactions 14 5.28e-01 -9.74e-02 6.48e-01
Activation of GABAB receptors 18 4.76e-01 9.70e-02 6.05e-01
GABA B receptor activation 18 4.76e-01 9.70e-02 6.05e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 16 5.02e-01 -9.68e-02 6.28e-01
GPER1 signaling 25 4.02e-01 9.68e-02 5.37e-01
Mucopolysaccharidoses 10 5.99e-01 9.61e-02 7.02e-01
trans-Golgi Network Vesicle Budding 51 2.36e-01 -9.61e-02 3.61e-01
FCERI mediated Ca+2 mobilization 23 4.26e-01 -9.58e-02 5.63e-01
Amino acid transport across the plasma membrane 16 5.09e-01 -9.54e-02 6.34e-01
Intraflagellar transport 33 3.44e-01 -9.53e-02 4.79e-01
Oxidative Stress Induced Senescence 55 2.22e-01 -9.52e-02 3.47e-01
Pre-NOTCH Transcription and Translation 31 3.60e-01 -9.50e-02 4.99e-01
Macroautophagy 97 1.09e-01 -9.44e-02 1.99e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 29 3.80e-01 -9.42e-02 5.18e-01
Signaling by RAS mutants 29 3.80e-01 -9.42e-02 5.18e-01
Signaling by moderate kinase activity BRAF mutants 29 3.80e-01 -9.42e-02 5.18e-01
Signaling downstream of RAS mutants 29 3.80e-01 -9.42e-02 5.18e-01
Early Phase of HIV Life Cycle 13 5.59e-01 -9.37e-02 6.73e-01
Frs2-mediated activation 11 5.93e-01 -9.30e-02 7.01e-01
Signaling by NTRKs 87 1.35e-01 -9.29e-02 2.37e-01
Transcriptional regulation by RUNX1 137 6.22e-02 -9.25e-02 1.34e-01
PLC beta mediated events 29 3.90e-01 -9.23e-02 5.27e-01
Golgi Associated Vesicle Biogenesis 38 3.25e-01 -9.23e-02 4.61e-01
Diseases of carbohydrate metabolism 23 4.46e-01 -9.17e-02 5.83e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 15 5.44e-01 -9.06e-02 6.61e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 5.61e-01 -8.98e-02 6.75e-01
Collagen formation 28 4.13e-01 8.93e-02 5.49e-01
RNA Polymerase II Transcription Termination 45 3.01e-01 -8.92e-02 4.36e-01
Vasopressin regulates renal water homeostasis via Aquaporins 23 4.59e-01 8.92e-02 5.90e-01
Glucagon-type ligand receptors 14 5.64e-01 8.90e-02 6.76e-01
Metal ion SLC transporters 16 5.38e-01 -8.90e-02 6.55e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 26 4.32e-01 -8.90e-02 5.69e-01
Synthesis of PC 22 4.72e-01 -8.85e-02 6.01e-01
Signaling by NTRK1 (TRKA) 79 1.75e-01 -8.83e-02 2.88e-01
G beta:gamma signalling through BTK 11 6.14e-01 8.79e-02 7.16e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 29 4.15e-01 8.75e-02 5.49e-01
VEGFR2 mediated cell proliferation 16 5.45e-01 -8.73e-02 6.61e-01
Thromboxane signalling through TP receptor 15 5.58e-01 8.73e-02 6.73e-01
Keratan sulfate biosynthesis 14 5.73e-01 -8.69e-02 6.83e-01
Signaling by ALK fusions and activated point mutants 46 3.08e-01 -8.69e-02 4.43e-01
Signaling by ALK in cancer 46 3.08e-01 -8.69e-02 4.43e-01
CD209 (DC-SIGN) signaling 15 5.63e-01 -8.62e-02 6.76e-01
HCMV Late Events 51 2.87e-01 -8.62e-02 4.21e-01
PKA activation 10 6.44e-01 8.44e-02 7.44e-01
Signal Transduction 1356 4.14e-07 -8.42e-02 1.84e-05
Netrin-1 signaling 25 4.69e-01 8.37e-02 5.99e-01
Muscle contraction 67 2.39e-01 -8.32e-02 3.65e-01
Effects of PIP2 hydrolysis 19 5.30e-01 8.32e-02 6.48e-01
FOXO-mediated transcription 46 3.29e-01 -8.32e-02 4.65e-01
Transcriptional Regulation by MECP2 31 4.25e-01 -8.29e-02 5.61e-01
Interleukin-2 family signaling 28 4.49e-01 -8.28e-02 5.84e-01
Assembly and cell surface presentation of NMDA receptors 13 6.06e-01 8.26e-02 7.08e-01
Telomere Extension By Telomerase 20 5.23e-01 -8.26e-02 6.45e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 38 3.79e-01 -8.26e-02 5.18e-01
Hemostasis 304 1.39e-02 -8.25e-02 4.49e-02
Glucagon signaling in metabolic regulation 18 5.45e-01 8.25e-02 6.61e-01
Negative regulation of MET activity 16 5.69e-01 -8.22e-02 6.80e-01
Transport of vitamins, nucleosides, and related molecules 21 5.16e-01 8.19e-02 6.41e-01
Suppression of phagosomal maturation 12 6.25e-01 -8.16e-02 7.26e-01
Signaling by ERBB2 TMD/JMD mutants 10 6.56e-01 -8.15e-02 7.53e-01
RAF activation 28 4.56e-01 -8.14e-02 5.87e-01
rRNA modification in the nucleus and cytosol 49 3.26e-01 -8.12e-02 4.61e-01
Signalling to ERKs 25 4.83e-01 -8.10e-02 6.10e-01
COPI-independent Golgi-to-ER retrograde traffic 29 4.54e-01 -8.04e-02 5.86e-01
CDC42 GTPase cycle 97 1.76e-01 7.96e-02 2.90e-01
Neurexins and neuroligins 21 5.29e-01 -7.93e-02 6.48e-01
Inactivation, recovery and regulation of the phototransduction cascade 17 5.72e-01 7.92e-02 6.82e-01
IRS-mediated signalling 21 5.32e-01 7.87e-02 6.50e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 27 4.81e-01 -7.83e-02 6.08e-01
HSF1 activation 21 5.35e-01 -7.82e-02 6.52e-01
SLC transporter disorders 52 3.30e-01 -7.82e-02 4.65e-01
RND1 GTPase cycle 29 4.80e-01 -7.59e-02 6.07e-01
Unfolded Protein Response (UPR) 76 2.56e-01 -7.55e-02 3.85e-01
PKMTs methylate histone lysines 31 4.70e-01 7.50e-02 5.99e-01
Signaling by ERBB2 33 4.56e-01 -7.50e-02 5.87e-01
Oncogenic MAPK signaling 56 3.32e-01 -7.49e-02 4.67e-01
Recycling pathway of L1 15 6.17e-01 7.45e-02 7.19e-01
Diseases associated with O-glycosylation of proteins 21 5.58e-01 7.39e-02 6.73e-01
Metalloprotease DUBs 17 5.98e-01 -7.38e-02 7.02e-01
Autophagy 106 1.91e-01 -7.36e-02 3.07e-01
Integrin cell surface interactions 25 5.26e-01 -7.34e-02 6.47e-01
RHOV GTPase cycle 28 5.04e-01 -7.30e-02 6.29e-01
Immune System 1156 4.50e-05 -7.28e-02 5.82e-04
Insulin receptor signalling cascade 26 5.28e-01 7.15e-02 6.48e-01
Synthesis of PA 18 6.01e-01 7.12e-02 7.03e-01
Assembly Of The HIV Virion 14 6.45e-01 7.10e-02 7.44e-01
PI3K/AKT Signaling in Cancer 52 3.77e-01 -7.09e-02 5.17e-01
Signaling by ERBB2 in Cancer 13 6.61e-01 -7.03e-02 7.58e-01
Platelet homeostasis 49 3.99e-01 -6.97e-02 5.34e-01
RHOBTB1 GTPase cycle 18 6.14e-01 -6.87e-02 7.16e-01
Interferon gamma signaling 55 3.79e-01 -6.87e-02 5.18e-01
FCERI mediated MAPK activation 23 5.69e-01 -6.86e-02 6.80e-01
Energy dependent regulation of mTOR by LKB1-AMPK 25 5.55e-01 -6.82e-02 6.71e-01
Potential therapeutics for SARS 66 3.39e-01 -6.82e-02 4.74e-01
Budding and maturation of HIV virion 24 5.64e-01 6.80e-02 6.76e-01
Regulation of KIT signaling 10 7.11e-01 6.76e-02 8.00e-01
Synthesis of bile acids and bile salts 13 6.76e-01 6.70e-02 7.72e-01
Peroxisomal lipid metabolism 22 5.88e-01 -6.68e-02 6.97e-01
Inositol phosphate metabolism 30 5.27e-01 -6.67e-02 6.48e-01
mRNA 3’-end processing 37 4.83e-01 -6.66e-02 6.10e-01
G-protein beta:gamma signalling 21 5.98e-01 -6.65e-02 7.02e-01
Rab regulation of trafficking 94 2.66e-01 -6.65e-02 3.98e-01
activated TAK1 mediates p38 MAPK activation 13 6.80e-01 6.61e-02 7.76e-01
G alpha (12/13) signalling events 40 4.72e-01 6.58e-02 6.01e-01
Innate Immune System 620 6.39e-03 -6.49e-02 2.41e-02
GABA receptor activation 19 6.32e-01 6.35e-02 7.31e-01
MAP kinase activation 49 4.45e-01 -6.31e-02 5.83e-01
DAG and IP3 signaling 26 5.78e-01 -6.30e-02 6.87e-01
Transmission across Chemical Synapses 101 2.79e-01 6.25e-02 4.11e-01
Signal amplification 20 6.30e-01 6.22e-02 7.30e-01
Neuronal System 139 2.08e-01 6.20e-02 3.29e-01
Synthesis of substrates in N-glycan biosythesis 48 4.58e-01 -6.20e-02 5.89e-01
Fatty acid metabolism 104 2.77e-01 -6.19e-02 4.09e-01
Metabolism of fat-soluble vitamins 13 6.99e-01 -6.18e-02 7.92e-01
Platelet activation, signaling and aggregation 132 2.24e-01 -6.14e-02 3.48e-01
Insulin processing 17 6.64e-01 -6.09e-02 7.61e-01
O-linked glycosylation of mucins 26 5.92e-01 -6.08e-02 7.01e-01
Transcriptional activation of mitochondrial biogenesis 40 5.10e-01 -6.03e-02 6.35e-01
SUMOylation of transcription cofactors 35 5.39e-01 -6.01e-02 6.55e-01
RHOG GTPase cycle 49 4.68e-01 5.99e-02 5.99e-01
Ras activation upon Ca2+ influx through NMDA receptor 10 7.50e-01 5.83e-02 8.34e-01
Activation of BAD and translocation to mitochondria 14 7.09e-01 -5.77e-02 7.98e-01
Gap junction trafficking 10 7.62e-01 5.53e-02 8.41e-01
NRAGE signals death through JNK 30 6.01e-01 5.52e-02 7.03e-01
Growth hormone receptor signaling 17 6.99e-01 -5.42e-02 7.92e-01
Integration of energy metabolism 60 4.69e-01 -5.41e-02 5.99e-01
ADORA2B mediated anti-inflammatory cytokines production 33 5.94e-01 5.37e-02 7.01e-01
Sphingolipid metabolism 49 5.19e-01 -5.33e-02 6.43e-01
Interferon alpha/beta signaling 51 5.12e-01 -5.31e-02 6.36e-01
Mitochondrial calcium ion transport 19 6.90e-01 -5.29e-02 7.82e-01
Neurotransmitter release cycle 20 6.83e-01 -5.28e-02 7.77e-01
MAP2K and MAPK activation 25 6.48e-01 5.27e-02 7.47e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 7.65e-01 -5.21e-02 8.43e-01
RHOH GTPase cycle 29 6.28e-01 5.20e-02 7.29e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 27 6.40e-01 5.20e-02 7.40e-01
Pre-NOTCH Expression and Processing 46 5.45e-01 -5.16e-02 6.61e-01
HSF1-dependent transactivation 25 6.55e-01 -5.16e-02 7.53e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 22 6.75e-01 -5.16e-02 7.72e-01
TGF-beta receptor signaling activates SMADs 39 5.78e-01 -5.15e-02 6.87e-01
Downregulation of ERBB2 signaling 17 7.15e-01 -5.12e-02 8.01e-01
Regulation of lipid metabolism by PPARalpha 84 4.21e-01 -5.08e-02 5.57e-01
Regulation of MECP2 expression and activity 23 6.75e-01 -5.05e-02 7.72e-01
RUNX2 regulates osteoblast differentiation 13 7.53e-01 -5.03e-02 8.38e-01
Citric acid cycle (TCA cycle) 19 7.07e-01 -4.99e-02 7.97e-01
Nicotinate metabolism 19 7.07e-01 4.99e-02 7.97e-01
Prolonged ERK activation events 13 7.59e-01 -4.91e-02 8.41e-01
Late endosomal microautophagy 23 6.84e-01 4.90e-02 7.78e-01
Leishmania infection 112 3.73e-01 -4.88e-02 5.14e-01
Semaphorin interactions 39 5.99e-01 4.87e-02 7.02e-01
Signaling by BRAF and RAF1 fusions 42 5.87e-01 -4.85e-02 6.97e-01
PPARA activates gene expression 82 4.50e-01 -4.84e-02 5.85e-01
Synthesis of PIPs at the early endosome membrane 12 7.73e-01 -4.81e-02 8.50e-01
O-linked glycosylation 42 5.93e-01 4.78e-02 7.01e-01
TAK1-dependent IKK and NF-kappa-B activation 18 7.28e-01 -4.73e-02 8.13e-01
PI Metabolism 60 5.30e-01 -4.70e-02 6.48e-01
Transport of small molecules 359 1.29e-01 -4.70e-02 2.28e-01
Metabolism of lipids 439 9.46e-02 -4.69e-02 1.78e-01
Sialic acid metabolism 23 7.01e-01 -4.62e-02 7.92e-01
Regulation of BACH1 activity 11 7.91e-01 -4.62e-02 8.67e-01
Activation of the pre-replicative complex 30 6.65e-01 -4.57e-02 7.62e-01
Negative regulation of the PI3K/AKT network 56 5.55e-01 -4.56e-02 6.71e-01
Chondroitin sulfate/dermatan sulfate metabolism 27 6.83e-01 4.54e-02 7.77e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 7.87e-01 -4.51e-02 8.64e-01
Biological oxidations 79 4.91e-01 -4.49e-02 6.18e-01
Nuclear signaling by ERBB4 16 7.58e-01 -4.45e-02 8.40e-01
Interconversion of nucleotide di- and triphosphates 25 7.01e-01 -4.44e-02 7.92e-01
RHOC GTPase cycle 49 5.99e-01 4.35e-02 7.02e-01
Iron uptake and transport 38 6.46e-01 -4.31e-02 7.45e-01
Ca2+ pathway 40 6.38e-01 -4.30e-02 7.38e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 50 6.01e-01 -4.28e-02 7.03e-01
RHOB GTPase cycle 44 6.29e-01 4.21e-02 7.30e-01
Peptide hormone metabolism 31 6.85e-01 4.21e-02 7.78e-01
AKT phosphorylates targets in the cytosol 13 7.94e-01 -4.18e-02 8.67e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 16 7.73e-01 4.17e-02 8.50e-01
RAC2 GTPase cycle 56 5.97e-01 4.09e-02 7.02e-01
Synthesis of PIPs at the plasma membrane 36 6.72e-01 -4.08e-02 7.69e-01
PKA-mediated phosphorylation of CREB 11 8.18e-01 4.00e-02 8.84e-01
FCGR3A-mediated IL10 synthesis 22 7.49e-01 -3.94e-02 8.34e-01
Adrenaline,noradrenaline inhibits insulin secretion 15 7.93e-01 3.91e-02 8.67e-01
G beta:gamma signalling through PLC beta 13 8.12e-01 3.80e-02 8.80e-01
Presynaptic function of Kainate receptors 13 8.12e-01 3.80e-02 8.80e-01
Neurotransmitter receptors and postsynaptic signal transmission 77 5.68e-01 3.77e-02 6.80e-01
Termination of O-glycan biosynthesis 10 8.38e-01 -3.74e-02 8.97e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 31 7.22e-01 3.69e-02 8.08e-01
Protein-protein interactions at synapses 33 7.16e-01 -3.66e-02 8.02e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 19 7.87e-01 -3.57e-02 8.64e-01
Plasma lipoprotein remodeling 11 8.39e-01 3.54e-02 8.98e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 23 7.73e-01 -3.48e-02 8.50e-01
RHO GTPase cycle 294 3.14e-01 -3.43e-02 4.50e-01
VxPx cargo-targeting to cilium 16 8.15e-01 -3.38e-02 8.83e-01
Cell-Cell communication 48 6.87e-01 3.36e-02 7.80e-01
The role of Nef in HIV-1 replication and disease pathogenesis 19 8.02e-01 -3.32e-02 8.72e-01
RND3 GTPase cycle 29 7.62e-01 3.25e-02 8.41e-01
IRS-related events triggered by IGF1R 22 7.92e-01 3.25e-02 8.67e-01
Basigin interactions 14 8.36e-01 3.19e-02 8.97e-01
Integrin signaling 16 8.25e-01 3.19e-02 8.89e-01
Platelet Aggregation (Plug Formation) 16 8.25e-01 3.19e-02 8.89e-01
Deadenylation of mRNA 23 7.92e-01 -3.17e-02 8.67e-01
Carboxyterminal post-translational modifications of tubulin 24 7.88e-01 -3.17e-02 8.64e-01
ROS and RNS production in phagocytes 23 7.94e-01 3.14e-02 8.67e-01
Regulation of FZD by ubiquitination 12 8.51e-01 -3.13e-02 9.08e-01
Signaling by Insulin receptor 42 7.26e-01 3.12e-02 8.12e-01
Uptake and actions of bacterial toxins 18 8.19e-01 -3.12e-02 8.84e-01
RHOBTB2 GTPase cycle 20 8.10e-01 -3.10e-02 8.80e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 10 8.76e-01 -2.86e-02 9.29e-01
Lysosome Vesicle Biogenesis 24 8.09e-01 -2.84e-02 8.80e-01
SLC-mediated transmembrane transport 105 6.20e-01 2.81e-02 7.21e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 45 7.45e-01 -2.80e-02 8.32e-01
Diseases associated with the TLR signaling cascade 17 8.43e-01 -2.78e-02 9.00e-01
Diseases of Immune System 17 8.43e-01 -2.78e-02 9.00e-01
Cardiac conduction 43 7.56e-01 2.74e-02 8.40e-01
RAB GEFs exchange GTP for GDP on RABs 64 7.12e-01 2.67e-02 8.00e-01
Glycosaminoglycan metabolism 64 7.14e-01 -2.65e-02 8.01e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 8.16e-01 -2.59e-02 8.83e-01
RHOU GTPase cycle 32 8.01e-01 2.58e-02 8.72e-01
Maturation of nucleoprotein 11 8.83e-01 -2.55e-02 9.32e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 10 8.89e-01 2.54e-02 9.36e-01
Myogenesis 13 8.75e-01 -2.52e-02 9.29e-01
Membrane binding and targetting of GAG proteins 12 8.81e-01 -2.50e-02 9.31e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 8.81e-01 -2.50e-02 9.31e-01
Interleukin-17 signaling 52 7.57e-01 -2.48e-02 8.40e-01
RET signaling 23 8.37e-01 -2.47e-02 8.97e-01
Ca-dependent events 21 8.45e-01 -2.47e-02 9.02e-01
Opioid Signalling 58 7.47e-01 -2.45e-02 8.33e-01
Retinoid metabolism and transport 11 8.90e-01 -2.41e-02 9.36e-01
Anti-inflammatory response favouring Leishmania parasite infection 54 7.61e-01 2.40e-02 8.41e-01
Leishmania parasite growth and survival 54 7.61e-01 2.40e-02 8.41e-01
Regulation of insulin secretion 40 8.02e-01 2.30e-02 8.72e-01
N-glycan antennae elongation in the medial/trans-Golgi 17 8.70e-01 -2.29e-02 9.25e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 11 8.97e-01 -2.26e-02 9.41e-01
E2F mediated regulation of DNA replication 19 8.68e-01 2.20e-02 9.23e-01
MTOR signalling 36 8.19e-01 2.20e-02 8.84e-01
Visual phototransduction 34 8.30e-01 2.13e-02 8.92e-01
Insulin receptor recycling 17 8.79e-01 -2.12e-02 9.31e-01
ER Quality Control Compartment (ERQC) 18 8.76e-01 -2.12e-02 9.29e-01
Sema3A PAK dependent Axon repulsion 11 9.05e-01 2.08e-02 9.48e-01
Cytosolic sulfonation of small molecules 10 9.13e-01 -1.99e-02 9.55e-01
Pyroptosis 18 8.86e-01 -1.95e-02 9.33e-01
RAB geranylgeranylation 40 8.32e-01 -1.94e-02 8.94e-01
XBP1(S) activates chaperone genes 42 8.30e-01 1.92e-02 8.92e-01
Phospholipid metabolism 133 7.12e-01 -1.86e-02 8.00e-01
Syndecan interactions 10 9.21e-01 -1.81e-02 9.57e-01
Signaling by high-kinase activity BRAF mutants 22 8.86e-01 -1.77e-02 9.33e-01
Neutrophil degranulation 307 5.98e-01 -1.76e-02 7.02e-01
NR1H2 and NR1H3-mediated signaling 27 8.77e-01 1.72e-02 9.29e-01
Dopamine Neurotransmitter Release Cycle 12 9.18e-01 1.71e-02 9.56e-01
Regulation of IFNG signaling 13 9.16e-01 1.69e-02 9.56e-01
ADP signalling through P2Y purinoceptor 12 13 9.20e-01 1.61e-02 9.57e-01
FOXO-mediated transcription of cell cycle genes 13 9.20e-01 -1.61e-02 9.57e-01
L1CAM interactions 41 8.64e-01 1.55e-02 9.20e-01
Activation of NMDA receptors and postsynaptic events 44 8.62e-01 -1.51e-02 9.19e-01
Ephrin signaling 12 9.32e-01 1.42e-02 9.63e-01
Sema4D induced cell migration and growth-cone collapse 12 9.33e-01 1.39e-02 9.63e-01
NOD1/2 Signaling Pathway 23 9.08e-01 1.39e-02 9.51e-01
Processing of SMDT1 13 9.32e-01 -1.37e-02 9.63e-01
Metabolic disorders of biological oxidation enzymes 14 9.29e-01 -1.37e-02 9.63e-01
Regulation of innate immune responses to cytosolic DNA 12 9.37e-01 1.31e-02 9.65e-01
Transport of bile salts and organic acids, metal ions and amine compounds 34 8.95e-01 1.31e-02 9.40e-01
DARPP-32 events 21 9.18e-01 1.30e-02 9.56e-01
Detoxification of Reactive Oxygen Species 23 9.18e-01 -1.24e-02 9.56e-01
G beta:gamma signalling through CDC42 13 9.38e-01 -1.24e-02 9.66e-01
G beta:gamma signalling through PI3Kgamma 17 9.32e-01 1.20e-02 9.63e-01
Constitutive Signaling by Aberrant PI3K in Cancer 28 9.13e-01 1.19e-02 9.55e-01
IRE1alpha activates chaperones 43 9.00e-01 1.11e-02 9.44e-01
RHO GTPases Activate NADPH Oxidases 14 9.44e-01 -1.08e-02 9.69e-01
CTLA4 inhibitory signaling 16 9.43e-01 -1.03e-02 9.69e-01
Sema4D in semaphorin signaling 15 9.48e-01 -9.72e-03 9.71e-01
Attenuation phase 19 9.49e-01 -8.51e-03 9.71e-01
IGF1R signaling cascade 23 9.44e-01 8.41e-03 9.69e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 23 9.44e-01 8.41e-03 9.69e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 33 9.35e-01 -8.22e-03 9.64e-01
Sensory processing of sound by outer hair cells of the cochlea 18 9.53e-01 -8.10e-03 9.73e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 14 9.58e-01 8.08e-03 9.77e-01
Amino acids regulate mTORC1 42 9.31e-01 7.70e-03 9.63e-01
Activation of BH3-only proteins 27 9.46e-01 -7.58e-03 9.69e-01
Heparan sulfate/heparin (HS-GAG) metabolism 22 9.52e-01 -7.40e-03 9.73e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 20 9.60e-01 6.54e-03 9.77e-01
Sensory Perception 68 9.32e-01 6.03e-03 9.63e-01
RUNX2 regulates bone development 18 9.68e-01 5.53e-03 9.82e-01
RHOA GTPase cycle 93 9.30e-01 5.30e-03 9.63e-01
RND2 GTPase cycle 34 9.58e-01 5.20e-03 9.77e-01
Post NMDA receptor activation events 38 9.59e-01 -4.85e-03 9.77e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 14 9.76e-01 -4.57e-03 9.89e-01
Signaling by RAF1 mutants 25 9.70e-01 -4.40e-03 9.84e-01
Glutamate Neurotransmitter Release Cycle 12 9.80e-01 4.11e-03 9.90e-01
Interleukin-10 signaling 13 9.80e-01 -3.98e-03 9.90e-01
Cell surface interactions at the vascular wall 56 9.64e-01 3.45e-03 9.80e-01
Ion channel transport 80 9.63e-01 3.01e-03 9.79e-01
MET promotes cell motility 13 9.87e-01 2.70e-03 9.91e-01
CaM pathway 20 9.83e-01 -2.69e-03 9.90e-01
Calmodulin induced events 20 9.83e-01 -2.69e-03 9.90e-01
Pre-NOTCH Processing in Golgi 16 9.86e-01 -2.45e-03 9.91e-01
Sensory processing of sound 27 9.83e-01 -2.40e-03 9.90e-01
Sensory processing of sound by inner hair cells of the cochlea 27 9.83e-01 -2.40e-03 9.90e-01
Transferrin endocytosis and recycling 19 9.87e-01 -2.13e-03 9.91e-01
RAC1 GTPase cycle 110 9.77e-01 -1.61e-03 9.89e-01
NCAM signaling for neurite out-growth 24 9.90e-01 -1.47e-03 9.93e-01
Nuclear events stimulated by ALK signaling in cancer 14 9.93e-01 -1.37e-03 9.95e-01
Glycerophospholipid biosynthesis 74 9.84e-01 1.36e-03 9.90e-01
Synthesis of PIPs at the Golgi membrane 12 9.98e-01 -3.40e-04 1.00e+00
Cell recruitment (pro-inflammatory response) 15 1.00e+00 -3.89e-05 1.00e+00
Purinergic signaling in leishmaniasis infection 15 1.00e+00 -3.89e-05 1.00e+00


Detailed Gene set reports



TNFs bind their physiological receptors

TNFs bind their physiological receptors
1066
set TNFs bind their physiological receptors
setSize 10
pANOVA 0.00241
s.dist 0.554
p.adjustANOVA 0.0112



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNFRSF25 651.5
LTA 596.5
EDARADD 0.5
TNFSF14 0.5
TNFRSF1B -1157.5
CD27 -2195.5
TNFSF13 -3700.0
TNFSF9 -4175.5
TNFSF13B -4319.5
TNFRSF1A -5433.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNFRSF25 651.5
LTA 596.5
EDARADD 0.5
TNFSF14 0.5
TNFRSF1B -1157.5
CD27 -2195.5
TNFSF13 -3700.0
TNFSF9 -4175.5
TNFSF13B -4319.5
TNFRSF1A -5433.5


Defects in vitamin and cofactor metabolism

Defects in vitamin and cofactor metabolism
217
set Defects in vitamin and cofactor metabolism
setSize 16
pANOVA 0.000555
s.dist -0.499
p.adjustANOVA 0.00374



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACACA -11258.5
MCCC1 -11162.5
MMAB -11063.0
MTR -10517.5
MMACHC -9846.0
MMAA -9022.5
HLCS -8568.5
MTRR -8567.5
BTD -8453.0
CD320 -7239.5
MCCC2 -7206.5
ABCD4 -6805.5
LMBRD1 -6796.5
PCCB -5987.5
MMADHC -5467.5
PC -4646.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACACA -11258.5
MCCC1 -11162.5
MMAB -11063.0
MTR -10517.5
MMACHC -9846.0
MMAA -9022.5
HLCS -8568.5
MTRR -8567.5
BTD -8453.0
CD320 -7239.5
MCCC2 -7206.5
ABCD4 -6805.5
LMBRD1 -6796.5
PCCB -5987.5
MMADHC -5467.5
PC -4646.5


Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
174
set Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
setSize 19
pANOVA 0.000218
s.dist -0.49
p.adjustANOVA 0.0018



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBA1B -10712.5
PFDN5 -10687.5
CCT8 -10444.5
CCT6A -10324.5
CCT3 -10159.5
ACTB -9696.5
PFDN2 -9596.0
PFDN1 -9068.5
TUBA1C -9044.5
CCT7 -8872.5
PFDN4 -8700.5
TUBA4A -8301.0
TUBA4B -8301.0
CCT5 -7749.0
TUBB2A -7422.5
TUBA1A -6890.5
CCT2 -4636.5
TUBB4B -4402.5
TCP1 -1472.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBA1B -10712.5
PFDN5 -10687.5
CCT8 -10444.5
CCT6A -10324.5
CCT3 -10159.5
ACTB -9696.5
PFDN2 -9596.0
PFDN1 -9068.5
TUBA1C -9044.5
CCT7 -8872.5
PFDN4 -8700.5
TUBA4A -8301.0
TUBA4B -8301.0
CCT5 -7749.0
TUBB2A -7422.5
TUBA1A -6890.5
CCT2 -4636.5
TUBB4B -4402.5
TCP1 -1472.0


Caspase activation via Death Receptors in the presence of ligand

Caspase activation via Death Receptors in the presence of ligand
120
set Caspase activation via Death Receptors in the presence of ligand
setSize 10
pANOVA 0.00809
s.dist -0.484
p.adjustANOVA 0.029



Top enriched genes

Top 20 genes
GeneID Gene Rank
CFLAR -11075.5
CASP8 -10911.5
TICAM1 -10439.5
TRADD -9330.0
FADD -9159.5
TNFRSF10A -7567.5
TNFRSF10B -7324.5
TRAF2 -7066.5
FAS -6781.0
TNFSF10 -2341.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CFLAR -11075.5
CASP8 -10911.5
TICAM1 -10439.5
TRADD -9330.0
FADD -9159.5
TNFRSF10A -7567.5
TNFRSF10B -7324.5
TRAF2 -7066.5
FAS -6781.0
TNFSF10 -2341.5


Prefoldin mediated transfer of substrate to CCT/TriC

Prefoldin mediated transfer of substrate to CCT/TriC
725
set Prefoldin mediated transfer of substrate to CCT/TriC
setSize 17
pANOVA 0.000903
s.dist -0.465
p.adjustANOVA 0.00512



Top enriched genes

Top 20 genes
GeneID Gene Rank
PFDN5 -10687.5
CCT8 -10444.5
CCT6A -10324.5
CCT3 -10159.5
ACTB -9696.5
PFDN2 -9596.0
PFDN1 -9068.5
TUBA1C -9044.5
CCT7 -8872.5
PFDN4 -8700.5
TUBA4A -8301.0
CCT5 -7749.0
TUBB2A -7422.5
TUBA1A -6890.5
CCT2 -4636.5
TUBB4B -4402.5
TCP1 -1472.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PFDN5 -10687.5
CCT8 -10444.5
CCT6A -10324.5
CCT3 -10159.5
ACTB -9696.5
PFDN2 -9596.0
PFDN1 -9068.5
TUBA1C -9044.5
CCT7 -8872.5
PFDN4 -8700.5
TUBA4A -8301.0
CCT5 -7749.0
TUBB2A -7422.5
TUBA1A -6890.5
CCT2 -4636.5
TUBB4B -4402.5
TCP1 -1472.0


Purine salvage

Purine salvage
745
set Purine salvage
setSize 11
pANOVA 0.00773
s.dist -0.464
p.adjustANOVA 0.0281



Top enriched genes

Top 20 genes
GeneID Gene Rank
ADK -11274.5
ADAL -10553.0
PNP -9342.5
AMPD3 -9294.5
AMPD2 -9180.5
GMPR2 -8938.0
APRT -7498.5
DCK -6623.5
GMPR -5678.5
DGUOK -5317.5
ADA -5187.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADK -11274.5
ADAL -10553.0
PNP -9342.5
AMPD3 -9294.5
AMPD2 -9180.5
GMPR2 -8938.0
APRT -7498.5
DCK -6623.5
GMPR -5678.5
DGUOK -5317.5
ADA -5187.5


Inhibition of DNA recombination at telomere

Inhibition of DNA recombination at telomere
448
set Inhibition of DNA recombination at telomere
setSize 18
pANOVA 0.000733
s.dist -0.46
p.adjustANOVA 0.00433



Top enriched genes

Top 20 genes
GeneID Gene Rank
TERF2IP -11234.0
DAXX -11158.5
POLR2B -10380.5
POLR2A -10062.5
POLR2D -9509.5
POLR2H -9508.5
POLR2F -9393.0
POLR2I -9058.0
TINF2 -8933.5
TERF2 -8530.5
POLR2C -8435.5
TERF1 -7605.5
POLR2E -7045.5
H2AFX -6312.5
POLR2L -5852.0
ACD -4582.0
POLR2K -4210.5
POLR2G -3174.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TERF2IP -11234.0
DAXX -11158.5
POLR2B -10380.5
POLR2A -10062.5
POLR2D -9509.5
POLR2H -9508.5
POLR2F -9393.0
POLR2I -9058.0
TINF2 -8933.5
TERF2 -8530.5
POLR2C -8435.5
TERF1 -7605.5
POLR2E -7045.5
H2AFX -6312.5
POLR2L -5852.0
ACD -4582.0
POLR2K -4210.5
POLR2G -3174.5


Meiotic recombination

Meiotic recombination
533
set Meiotic recombination
setSize 19
pANOVA 0.000555
s.dist -0.458
p.adjustANOVA 0.00374



Top enriched genes

Top 20 genes
GeneID Gene Rank
MSH5 -11271.5
PSMC3IP -11217.5
ATM -11206.0
BLM -10701.5
TOP3A -10587.0
DMC1 -10456.5
RBBP8 -10259.5
CDK4 -10143.5
RAD51 -9480.5
RPA1 -9406.0
RPA3 -7320.5
MND1 -7238.5
NBN -6868.5
H2AFX -6312.5
BRCA2 -6291.5
BRCA1 -5890.0
CDK2 -3570.5
RAD50 -2434.5
MLH3 -2132.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MSH5 -11271.5
PSMC3IP -11217.5
ATM -11206.0
BLM -10701.5
TOP3A -10587.0
DMC1 -10456.5
RBBP8 -10259.5
CDK4 -10143.5
RAD51 -9480.5
RPA1 -9406.0
RPA3 -7320.5
MND1 -7238.5
NBN -6868.5
H2AFX -6312.5
BRCA2 -6291.5
BRCA1 -5890.0
CDK2 -3570.5
RAD50 -2434.5
MLH3 -2132.5


Signaling by FGFR2 IIIa TM

Signaling by FGFR2 IIIa TM
971
set Signaling by FGFR2 IIIa TM
setSize 15
pANOVA 0.0028
s.dist -0.446
p.adjustANOVA 0.0126



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCBP1 -10889.0
GTF2F2 -10792.5
POLR2B -10380.5
POLR2A -10062.5
POLR2D -9509.5
POLR2H -9508.5
POLR2F -9393.0
POLR2I -9058.0
POLR2C -8435.5
GTF2F1 -8403.5
POLR2E -7045.5
POLR2L -5852.0
POLR2K -4210.5
POLR2G -3174.5
NCBP2 -2848.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCBP1 -10889.0
GTF2F2 -10792.5
POLR2B -10380.5
POLR2A -10062.5
POLR2D -9509.5
POLR2H -9508.5
POLR2F -9393.0
POLR2I -9058.0
POLR2C -8435.5
GTF2F1 -8403.5
POLR2E -7045.5
POLR2L -5852.0
POLR2K -4210.5
POLR2G -3174.5
NCBP2 -2848.5


Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes
164
set Condensation of Prometaphase Chromosomes
setSize 10
pANOVA 0.0154
s.dist -0.442
p.adjustANOVA 0.048



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSNK2B -11296.5
NCAPD2 -10529.5
CDK1 -10144.5
SMC2 -9472.5
NCAPH -9126.5
SMC4 -8328.5
CCNB2 -7937.5
NCAPG -7347.0
CSNK2A2 -2759.5
CCNB1 -2583.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSNK2B -11296.5
NCAPD2 -10529.5
CDK1 -10144.5
SMC2 -9472.5
NCAPH -9126.5
SMC4 -8328.5
CCNB2 -7937.5
NCAPG -7347.0
CSNK2A2 -2759.5
CCNB1 -2583.5


RIPK1-mediated regulated necrosis

RIPK1-mediated regulated necrosis
784
set RIPK1-mediated regulated necrosis
setSize 25
pANOVA 0.000164
s.dist -0.436
p.adjustANOVA 0.00151



Top enriched genes

Top 20 genes
GeneID Gene Rank
CFLAR -11075.5
CASP8 -10911.5
BIRC2 -10872.5
FLOT1 -10585.5
HSP90AA1 -10508.5
PDCD6IP -10453.5
PELI1 -10043.5
RPS27A -9583.5
TRADD -9330.0
FADD -9159.5
UBA52 -8982.5
CDC37 -8074.0
RIPK3 -7870.5
TNFRSF10A -7567.5
TNFRSF10B -7324.5
TRAF2 -7066.5
UBC -7043.5
FAS -6781.0
STUB1 -6445.5
BIRC3 -5799.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CFLAR -11075.5
CASP8 -10911.5
BIRC2 -10872.5
FLOT1 -10585.5
HSP90AA1 -10508.5
PDCD6IP -10453.5
PELI1 -10043.5
RPS27A -9583.5
TRADD -9330.0
FADD -9159.5
UBA52 -8982.5
CDC37 -8074.0
RIPK3 -7870.5
TNFRSF10A -7567.5
TNFRSF10B -7324.5
TRAF2 -7066.5
UBC -7043.5
FAS -6781.0
STUB1 -6445.5
BIRC3 -5799.5
SDCBP -5784.5
UBB -5598.5
FLOT2 -5458.5
MLKL -3044.5
TNFSF10 -2341.5


Regulation of necroptotic cell death

Regulation of necroptotic cell death
870
set Regulation of necroptotic cell death
setSize 25
pANOVA 0.000164
s.dist -0.436
p.adjustANOVA 0.00151



Top enriched genes

Top 20 genes
GeneID Gene Rank
CFLAR -11075.5
CASP8 -10911.5
BIRC2 -10872.5
FLOT1 -10585.5
HSP90AA1 -10508.5
PDCD6IP -10453.5
PELI1 -10043.5
RPS27A -9583.5
TRADD -9330.0
FADD -9159.5
UBA52 -8982.5
CDC37 -8074.0
RIPK3 -7870.5
TNFRSF10A -7567.5
TNFRSF10B -7324.5
TRAF2 -7066.5
UBC -7043.5
FAS -6781.0
STUB1 -6445.5
BIRC3 -5799.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CFLAR -11075.5
CASP8 -10911.5
BIRC2 -10872.5
FLOT1 -10585.5
HSP90AA1 -10508.5
PDCD6IP -10453.5
PELI1 -10043.5
RPS27A -9583.5
TRADD -9330.0
FADD -9159.5
UBA52 -8982.5
CDC37 -8074.0
RIPK3 -7870.5
TNFRSF10A -7567.5
TNFRSF10B -7324.5
TRAF2 -7066.5
UBC -7043.5
FAS -6781.0
STUB1 -6445.5
BIRC3 -5799.5
SDCBP -5784.5
UBB -5598.5
FLOT2 -5458.5
MLKL -3044.5
TNFSF10 -2341.5


Glycogen synthesis

Glycogen synthesis
388
set Glycogen synthesis
setSize 11
pANOVA 0.0145
s.dist -0.426
p.adjustANOVA 0.046



Top enriched genes

Top 20 genes
GeneID Gene Rank
UGP2 -11222.5
GYG1 -10809.5
PGM1 -10591.5
PGM2 -10037.5
RPS27A -9583.5
UBA52 -8982.5
PGM2L1 -7677.5
UBC -7043.5
UBB -5598.5
GYS1 -5436.0
NHLRC1 605.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UGP2 -11222.5
GYG1 -10809.5
PGM1 -10591.5
PGM2 -10037.5
RPS27A -9583.5
UBA52 -8982.5
PGM2L1 -7677.5
UBC -7043.5
UBB -5598.5
GYS1 -5436.0
NHLRC1 605.5


Voltage gated Potassium channels

Voltage gated Potassium channels
1170
set Voltage gated Potassium channels
setSize 13
pANOVA 0.00817
s.dist 0.424
p.adjustANOVA 0.0291



Top enriched genes

Top 20 genes
GeneID Gene Rank
KCNC3 0.5
KCNH2 0.5
KCNA6 0.5
KCNAB2 -521.5
KCNS1 -542.5
KCNQ1 -863.0
KCNA3 -2713.5
KCNA2 -3695.5
KCNQ5 -4034.5
KCNC4 -4239.5
KCNG3 -4334.5
KCNQ4 -5235.5
KCNH4 -9656.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KCNC3 0.5
KCNH2 0.5
KCNA6 0.5
KCNAB2 -521.5
KCNS1 -542.5
KCNQ1 -863.0
KCNA3 -2713.5
KCNA2 -3695.5
KCNQ5 -4034.5
KCNC4 -4239.5
KCNG3 -4334.5
KCNQ4 -5235.5
KCNH4 -9656.5


Formation of tubulin folding intermediates by CCT/TriC

Formation of tubulin folding intermediates by CCT/TriC
332
set Formation of tubulin folding intermediates by CCT/TriC
setSize 14
pANOVA 0.00767
s.dist -0.412
p.adjustANOVA 0.0279



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBA1B -10712.5
CCT8 -10444.5
CCT6A -10324.5
CCT3 -10159.5
TUBA1C -9044.5
CCT7 -8872.5
TUBA4A -8301.0
TUBA4B -8301.0
CCT5 -7749.0
TUBB2A -7422.5
TUBA1A -6890.5
CCT2 -4636.5
TUBB4B -4402.5
TCP1 -1472.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBA1B -10712.5
CCT8 -10444.5
CCT6A -10324.5
CCT3 -10159.5
TUBA1C -9044.5
CCT7 -8872.5
TUBA4A -8301.0
TUBA4B -8301.0
CCT5 -7749.0
TUBB2A -7422.5
TUBA1A -6890.5
CCT2 -4636.5
TUBB4B -4402.5
TCP1 -1472.0


Removal of the Flap Intermediate

Removal of the Flap Intermediate
874
set Removal of the Flap Intermediate
setSize 12
pANOVA 0.0178
s.dist -0.395
p.adjustANOVA 0.054



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLA2 -10668.5
FEN1 -9524.5
RPA1 -9406.0
PRIM1 -9308.5
POLD4 -9141.5
DNA2 -9113.5
PCNA -8951.5
POLD3 -8818.5
RPA3 -7320.5
PRIM2 -6221.5
POLD2 -2749.5
POLD1 -804.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA2 -10668.5
FEN1 -9524.5
RPA1 -9406.0
PRIM1 -9308.5
POLD4 -9141.5
DNA2 -9113.5
PCNA -8951.5
POLD3 -8818.5
RPA3 -7320.5
PRIM2 -6221.5
POLD2 -2749.5
POLD1 -804.5


Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
33
set Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
setSize 13
pANOVA 0.015
s.dist -0.39
p.adjustANOVA 0.0471



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRF7 -10618.5
TICAM1 -10439.5
PTPN11 -9894.5
IRF3 -9873.0
RPS27A -9583.5
UBA52 -8982.5
TANK -8942.5
SARM1 -7988.5
UBC -7043.5
UBB -5598.5
IKBKE -5438.5
TBK1 -2559.5
TRAF3 -2305.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRF7 -10618.5
TICAM1 -10439.5
PTPN11 -9894.5
IRF3 -9873.0
RPS27A -9583.5
UBA52 -8982.5
TANK -8942.5
SARM1 -7988.5
UBC -7043.5
UBB -5598.5
IKBKE -5438.5
TBK1 -2559.5
TRAF3 -2305.5


mRNA decay by 5’ to 3’ exoribonuclease

mRNA decay by 5’ to 3’ exoribonuclease
1186
set mRNA decay by 5’ to 3’ exoribonuclease
setSize 15
pANOVA 0.00928
s.dist -0.388
p.adjustANOVA 0.0323



Top enriched genes

Top 20 genes
GeneID Gene Rank
LSM5 -11145.5
LSM3 -10994.5
LSM1 -10942.0
LSM7 -10866.5
LSM2 -10788.5
LSM4 -10438.5
DCP1A -10007.5
DCP2 -8802.5
EDC4 -7880.5
EDC3 -6558.5
DDX6 -5496.5
LSM6 -4380.5
PATL1 -4280.5
DCP1B -1795.5
XRN1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LSM5 -11145.5
LSM3 -10994.5
LSM1 -10942.0
LSM7 -10866.5
LSM2 -10788.5
LSM4 -10438.5
DCP1A -10007.5
DCP2 -8802.5
EDC4 -7880.5
EDC3 -6558.5
DDX6 -5496.5
LSM6 -4380.5
PATL1 -4280.5
DCP1B -1795.5
XRN1 0.5


Assembly of the ORC complex at the origin of replication

Assembly of the ORC complex at the origin of replication
66
set Assembly of the ORC complex at the origin of replication
setSize 10
pANOVA 0.0337
s.dist 0.388
p.adjustANOVA 0.0875



Top enriched genes

Top 20 genes
GeneID Gene Rank
ORC1 591.5
ORC3 0.5
ORC6 -1325.5
ORC5 -1709.5
ORC4 -1910.0
ORC2 -3702.5
KPNB1 -4172.5
KPNA6 -5389.5
KPNA1 -5782.5
H2AFX -6312.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC1 591.5
ORC3 0.5
ORC6 -1325.5
ORC5 -1709.5
ORC4 -1910.0
ORC2 -3702.5
KPNB1 -4172.5
KPNA6 -5389.5
KPNA1 -5782.5
H2AFX -6312.5


SARS-CoV-2 modulates autophagy

SARS-CoV-2 modulates autophagy
900
set SARS-CoV-2 modulates autophagy
setSize 11
pANOVA 0.0279
s.dist -0.383
p.adjustANOVA 0.0761



Top enriched genes

Top 20 genes
GeneID Gene Rank
VPS16 -10876.5
UVRAG -10842.5
VPS45 -10841.5
MAP1LC3B -10221.5
VPS18 -8672.5
VPS39 -8368.5
VPS11 -6800.5
VPS33A -6782.5
TUFM -5525.5
VPS33B -3705.5
VPS41 -914.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VPS16 -10876.5
UVRAG -10842.5
VPS45 -10841.5
MAP1LC3B -10221.5
VPS18 -8672.5
VPS39 -8368.5
VPS11 -6800.5
VPS33A -6782.5
TUFM -5525.5
VPS33B -3705.5
VPS41 -914.5


HDR through MMEJ (alt-NHEJ)

HDR through MMEJ (alt-NHEJ)
405
set HDR through MMEJ (alt-NHEJ)
setSize 11
pANOVA 0.0283
s.dist -0.382
p.adjustANOVA 0.0765



Top enriched genes

Top 20 genes
GeneID Gene Rank
RBBP8 -10259.5
RAD52 -10130.5
PARP2 -9848.5
FEN1 -9524.5
XRCC1 -8791.5
POLQ -8507.5
LIG3 -8229.5
NBN -6868.5
BRCA2 -6291.5
PARP1 -2589.5
RAD50 -2434.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBBP8 -10259.5
RAD52 -10130.5
PARP2 -9848.5
FEN1 -9524.5
XRCC1 -8791.5
POLQ -8507.5
LIG3 -8229.5
NBN -6868.5
BRCA2 -6291.5
PARP1 -2589.5
RAD50 -2434.5


Signaling by NOTCH2

Signaling by NOTCH2
993
set Signaling by NOTCH2
setSize 18
pANOVA 0.00544
s.dist -0.378
p.adjustANOVA 0.0211



Top enriched genes

Top 20 genes
GeneID Gene Rank
RBPJ -10880.5
PSENEN -10353.0
MAML2 -10227.5
RPS27A -9583.5
PSEN1 -9045.5
UBA52 -8982.5
APH1A -8586.5
PSEN2 -7934.5
MAML1 -7896.5
CREB1 -7720.5
UBC -7043.5
NCSTN -6880.0
EP300 -6231.5
APH1B -5786.5
ADAM10 -5735.5
UBB -5598.5
MIB1 -4361.5
MAML3 -3362.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBPJ -10880.5
PSENEN -10353.0
MAML2 -10227.5
RPS27A -9583.5
PSEN1 -9045.5
UBA52 -8982.5
APH1A -8586.5
PSEN2 -7934.5
MAML1 -7896.5
CREB1 -7720.5
UBC -7043.5
NCSTN -6880.0
EP300 -6231.5
APH1B -5786.5
ADAM10 -5735.5
UBB -5598.5
MIB1 -4361.5
MAML3 -3362.5


NRIF signals cell death from the nucleus

NRIF signals cell death from the nucleus
607
set NRIF signals cell death from the nucleus
setSize 14
pANOVA 0.0148
s.dist -0.376
p.adjustANOVA 0.0467



Top enriched genes

Top 20 genes
GeneID Gene Rank
ITGB3BP -11113.0
SQSTM1 -10463.5
PSENEN -10353.0
RPS27A -9583.5
PSEN1 -9045.5
UBA52 -8982.5
APH1A -8586.5
PSEN2 -7934.5
UBC -7043.5
NCSTN -6880.0
APH1B -5786.5
UBB -5598.5
TRAF6 -3105.5
MAPK8 -1292.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ITGB3BP -11113.0
SQSTM1 -10463.5
PSENEN -10353.0
RPS27A -9583.5
PSEN1 -9045.5
UBA52 -8982.5
APH1A -8586.5
PSEN2 -7934.5
UBC -7043.5
NCSTN -6880.0
APH1B -5786.5
UBB -5598.5
TRAF6 -3105.5
MAPK8 -1292.5


Pexophagy

Pexophagy
696
set Pexophagy
setSize 11
pANOVA 0.032
s.dist -0.373
p.adjustANOVA 0.0839



Top enriched genes

Top 20 genes
GeneID Gene Rank
NBR1 -11207.5
ATM -11206.0
SQSTM1 -10463.5
MAP1LC3B -10221.5
RPS27A -9583.5
UBA52 -8982.5
UBC -7043.5
PEX5 -6186.5
UBB -5598.5
USP30 -2422.5
EPAS1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NBR1 -11207.5
ATM -11206.0
SQSTM1 -10463.5
MAP1LC3B -10221.5
RPS27A -9583.5
UBA52 -8982.5
UBC -7043.5
PEX5 -6186.5
UBB -5598.5
USP30 -2422.5
EPAS1 0.5


Glyoxylate metabolism and glycine degradation

Glyoxylate metabolism and glycine degradation
392
set Glyoxylate metabolism and glycine degradation
setSize 19
pANOVA 0.00507
s.dist -0.371
p.adjustANOVA 0.0197



Top enriched genes

Top 20 genes
GeneID Gene Rank
ALDH4A1 -11176.5
GOT2 -11019.5
DLST -10590.5
DHTKD1 -10575.5
OGDH -9594.5
BCKDHA -8840.0
NDUFAB1 -8371.5
LIPT2 -8357.5
PDHB -8138.5
DBT -7606.5
GCSH -7008.0
BCKDHB -6241.5
LIAS -6172.0
DLAT -6098.5
PXMP2 -5878.0
GRHPR -5650.5
PDHX -4414.0
LIPT1 -3716.5
DLD -3525.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALDH4A1 -11176.5
GOT2 -11019.5
DLST -10590.5
DHTKD1 -10575.5
OGDH -9594.5
BCKDHA -8840.0
NDUFAB1 -8371.5
LIPT2 -8357.5
PDHB -8138.5
DBT -7606.5
GCSH -7008.0
BCKDHB -6241.5
LIAS -6172.0
DLAT -6098.5
PXMP2 -5878.0
GRHPR -5650.5
PDHX -4414.0
LIPT1 -3716.5
DLD -3525.5


IKK complex recruitment mediated by RIP1

IKK complex recruitment mediated by RIP1
430
set IKK complex recruitment mediated by RIP1
setSize 17
pANOVA 0.00843
s.dist -0.369
p.adjustANOVA 0.0299



Top enriched genes

Top 20 genes
GeneID Gene Rank
BIRC2 -10872.5
TICAM1 -10439.5
UBE2V1 -10318.5
UBE2D1 -9798.5
RPS27A -9583.5
UBE2D3 -9356.5
UBA52 -8982.5
UBE2D2 -8309.5
SARM1 -7988.5
RIPK3 -7870.5
UBC -7043.5
IKBKB -6899.5
BIRC3 -5799.5
UBB -5598.5
UBE2N -4780.5
TRAF6 -3105.5
CHUK -944.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BIRC2 -10872.5
TICAM1 -10439.5
UBE2V1 -10318.5
UBE2D1 -9798.5
RPS27A -9583.5
UBE2D3 -9356.5
UBA52 -8982.5
UBE2D2 -8309.5
SARM1 -7988.5
RIPK3 -7870.5
UBC -7043.5
IKBKB -6899.5
BIRC3 -5799.5
UBB -5598.5
UBE2N -4780.5
TRAF6 -3105.5
CHUK -944.5


alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
1178
set alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize 10
pANOVA 0.0439
s.dist -0.368
p.adjustANOVA 0.107



Top enriched genes

Top 20 genes
GeneID Gene Rank
ELOVL1 -11103.5
ACAA1 -10720.5
FADS1 -9787.5
FADS2 -9167.5
ACOT8 -8175.0
ACOX1 -7737.5
ELOVL5 -7420.5
HSD17B4 -4306.5
SCP2 -4016.5
ACSL1 -2628.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ELOVL1 -11103.5
ACAA1 -10720.5
FADS1 -9787.5
FADS2 -9167.5
ACOT8 -8175.0
ACOX1 -7737.5
ELOVL5 -7420.5
HSD17B4 -4306.5
SCP2 -4016.5
ACSL1 -2628.5


alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism
1179
set alpha-linolenic acid (ALA) metabolism
setSize 10
pANOVA 0.0439
s.dist -0.368
p.adjustANOVA 0.107



Top enriched genes

Top 20 genes
GeneID Gene Rank
ELOVL1 -11103.5
ACAA1 -10720.5
FADS1 -9787.5
FADS2 -9167.5
ACOT8 -8175.0
ACOX1 -7737.5
ELOVL5 -7420.5
HSD17B4 -4306.5
SCP2 -4016.5
ACSL1 -2628.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ELOVL1 -11103.5
ACAA1 -10720.5
FADS1 -9787.5
FADS2 -9167.5
ACOT8 -8175.0
ACOX1 -7737.5
ELOVL5 -7420.5
HSD17B4 -4306.5
SCP2 -4016.5
ACSL1 -2628.5


Translesion synthesis by POLK

Translesion synthesis by POLK
1131
set Translesion synthesis by POLK
setSize 15
pANOVA 0.014
s.dist -0.366
p.adjustANOVA 0.0449



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLK -10538.0
MAD2L2 -10266.5
RFC2 -9805.5
RPS27A -9583.5
RPA1 -9406.0
UBA52 -8982.5
PCNA -8951.5
RFC5 -7404.5
RPA3 -7320.5
UBC -7043.5
RFC4 -6979.5
REV3L -5853.5
UBB -5598.5
RFC3 -4707.5
REV1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLK -10538.0
MAD2L2 -10266.5
RFC2 -9805.5
RPS27A -9583.5
RPA1 -9406.0
UBA52 -8982.5
PCNA -8951.5
RFC5 -7404.5
RPA3 -7320.5
UBC -7043.5
RFC4 -6979.5
REV3L -5853.5
UBB -5598.5
RFC3 -4707.5
REV1 0.5


NOTCH2 Activation and Transmission of Signal to the Nucleus

NOTCH2 Activation and Transmission of Signal to the Nucleus
600
set NOTCH2 Activation and Transmission of Signal to the Nucleus
setSize 12
pANOVA 0.0283
s.dist -0.365
p.adjustANOVA 0.0765



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSENEN -10353.0
RPS27A -9583.5
PSEN1 -9045.5
UBA52 -8982.5
APH1A -8586.5
PSEN2 -7934.5
UBC -7043.5
NCSTN -6880.0
APH1B -5786.5
ADAM10 -5735.5
UBB -5598.5
MIB1 -4361.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSENEN -10353.0
RPS27A -9583.5
PSEN1 -9045.5
UBA52 -8982.5
APH1A -8586.5
PSEN2 -7934.5
UBC -7043.5
NCSTN -6880.0
APH1B -5786.5
ADAM10 -5735.5
UBB -5598.5
MIB1 -4361.5


Processive synthesis on the lagging strand

Processive synthesis on the lagging strand
734
set Processive synthesis on the lagging strand
setSize 13
pANOVA 0.0226
s.dist -0.365
p.adjustANOVA 0.064



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLA2 -10668.5
FEN1 -9524.5
RPA1 -9406.0
PRIM1 -9308.5
POLD4 -9141.5
DNA2 -9113.5
PCNA -8951.5
POLD3 -8818.5
RPA3 -7320.5
PRIM2 -6221.5
LIG1 -5332.5
POLD2 -2749.5
POLD1 -804.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA2 -10668.5
FEN1 -9524.5
RPA1 -9406.0
PRIM1 -9308.5
POLD4 -9141.5
DNA2 -9113.5
PCNA -8951.5
POLD3 -8818.5
RPA3 -7320.5
PRIM2 -6221.5
LIG1 -5332.5
POLD2 -2749.5
POLD1 -804.5


Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D
1155
set Ubiquitin-dependent degradation of Cyclin D
setSize 44
pANOVA 2.97e-05
s.dist -0.364
p.adjustANOVA 0.000426



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
CCND1 -11200.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
CDK4 -10143.5
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
UBA52 -8982.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
CCND1 -11200.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
CDK4 -10143.5
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
UBA52 -8982.5
PSMA6 -8827.5
PSMC1 -8768.5
PSMA7 -8735.5
PSME3 -8021.5
PSME1 -7821.5
PSMB10 -7788.5
PSMD14 -7694.5
PSMC6 -7334.5
UBC -7043.5
PSMD3 -6675.5
PSMD8 -6444.5
PSMA1 -6029.5
UBB -5598.5
GSK3B -4927.5
PSMD1 -4665.5
PSMD9 -4235.5
PSMD11 -3236.5
PSMC4 -2887.5
PSME4 -2566.5
PSMD6 -2202.5
PSMD2 -1784.5
PSMB7 -897.5
PSMB2 0.5
PSMF1 0.5


Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
1154
set Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
setSize 44
pANOVA 2.98e-05
s.dist -0.364
p.adjustANOVA 0.000426



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
CHEK2 -9582.0
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
UBA52 -8982.5
CHEK1 -8833.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
CHEK2 -9582.0
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
UBA52 -8982.5
CHEK1 -8833.5
PSMA6 -8827.5
PSMC1 -8768.5
PSMA7 -8735.5
PSME3 -8021.5
CDC25A -7837.5
PSME1 -7821.5
PSMB10 -7788.5
PSMD14 -7694.5
PSMC6 -7334.5
UBC -7043.5
PSMD3 -6675.5
PSMD8 -6444.5
PSMA1 -6029.5
UBB -5598.5
PSMD1 -4665.5
PSMD9 -4235.5
PSMD11 -3236.5
PSMC4 -2887.5
PSME4 -2566.5
PSMD6 -2202.5
PSMD2 -1784.5
PSMB7 -897.5
PSMB2 0.5
PSMF1 0.5


p53-Independent DNA Damage Response

p53-Independent DNA Damage Response
1190
set p53-Independent DNA Damage Response
setSize 44
pANOVA 2.98e-05
s.dist -0.364
p.adjustANOVA 0.000426



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
CHEK2 -9582.0
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
UBA52 -8982.5
CHEK1 -8833.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
CHEK2 -9582.0
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
UBA52 -8982.5
CHEK1 -8833.5
PSMA6 -8827.5
PSMC1 -8768.5
PSMA7 -8735.5
PSME3 -8021.5
CDC25A -7837.5
PSME1 -7821.5
PSMB10 -7788.5
PSMD14 -7694.5
PSMC6 -7334.5
UBC -7043.5
PSMD3 -6675.5
PSMD8 -6444.5
PSMA1 -6029.5
UBB -5598.5
PSMD1 -4665.5
PSMD9 -4235.5
PSMD11 -3236.5
PSMC4 -2887.5
PSME4 -2566.5
PSMD6 -2202.5
PSMD2 -1784.5
PSMB7 -897.5
PSMB2 0.5
PSMF1 0.5


p53-Independent G1/S DNA damage checkpoint

p53-Independent G1/S DNA damage checkpoint
1191
set p53-Independent G1/S DNA damage checkpoint
setSize 44
pANOVA 2.98e-05
s.dist -0.364
p.adjustANOVA 0.000426



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
CHEK2 -9582.0
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
UBA52 -8982.5
CHEK1 -8833.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
CHEK2 -9582.0
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
UBA52 -8982.5
CHEK1 -8833.5
PSMA6 -8827.5
PSMC1 -8768.5
PSMA7 -8735.5
PSME3 -8021.5
CDC25A -7837.5
PSME1 -7821.5
PSMB10 -7788.5
PSMD14 -7694.5
PSMC6 -7334.5
UBC -7043.5
PSMD3 -6675.5
PSMD8 -6444.5
PSMA1 -6029.5
UBB -5598.5
PSMD1 -4665.5
PSMD9 -4235.5
PSMD11 -3236.5
PSMC4 -2887.5
PSME4 -2566.5
PSMD6 -2202.5
PSMD2 -1784.5
PSMB7 -897.5
PSMB2 0.5
PSMF1 0.5


HDR through Single Strand Annealing (SSA)

HDR through Single Strand Annealing (SSA)
406
set HDR through Single Strand Annealing (SSA)
setSize 35
pANOVA 0.000198
s.dist -0.364
p.adjustANOVA 0.00167



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAD17 -11266.0
ATM -11206.0
ATR -10719.5
BLM -10701.5
TOP3A -10587.0
TOPBP1 -10548.5
BRIP1 -10350.5
RBBP8 -10259.5
RAD52 -10130.5
RFC2 -9805.5
ATRIP -9788.5
RAD51 -9480.5
RPA1 -9406.0
DNA2 -9113.5
RMI1 -9026.0
ERCC4 -8979.5
RAD9A -8213.5
EXO1 -8017.5
ERCC1 -7890.5
ABL1 -7555.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD17 -11266.0
ATM -11206.0
ATR -10719.5
BLM -10701.5
TOP3A -10587.0
TOPBP1 -10548.5
BRIP1 -10350.5
RBBP8 -10259.5
RAD52 -10130.5
RFC2 -9805.5
ATRIP -9788.5
RAD51 -9480.5
RPA1 -9406.0
DNA2 -9113.5
RMI1 -9026.0
ERCC4 -8979.5
RAD9A -8213.5
EXO1 -8017.5
ERCC1 -7890.5
ABL1 -7555.5
RAD9B -7432.0
RFC5 -7404.5
RPA3 -7320.5
RFC4 -6979.5
NBN -6868.5
RAD1 -5939.0
BRCA1 -5890.0
KAT5 -5826.5
RFC3 -4707.5
RHNO1 -2437.5
RAD50 -2434.5
BARD1 -2204.5
RMI2 -1727.5
HUS1 -1409.5
WRN 0.5


Purine ribonucleoside monophosphate biosynthesis

Purine ribonucleoside monophosphate biosynthesis
744
set Purine ribonucleoside monophosphate biosynthesis
setSize 10
pANOVA 0.047
s.dist -0.363
p.adjustANOVA 0.111



Top enriched genes

Top 20 genes
GeneID Gene Rank
ADSL -10604.5
ATIC -9701.5
PFAS -9034.5
GMPS -8040.5
PAICS -8038.0
PPAT -8038.0
ADSS -7379.5
IMPDH2 -4843.5
ADSSL1 -4774.5
IMPDH1 -4292.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADSL -10604.5
ATIC -9701.5
PFAS -9034.5
GMPS -8040.5
PAICS -8038.0
PPAT -8038.0
ADSS -7379.5
IMPDH2 -4843.5
ADSSL1 -4774.5
IMPDH1 -4292.5


Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects

Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
21
set Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
setSize 16
pANOVA 0.0129
s.dist -0.359
p.adjustANOVA 0.0424



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCND1 -11200.5
CCND3 -11093.5
CDKN1B -10727.5
CCND2 -10505.5
RB1 -10500.5
CDK4 -10143.5
E2F3 -9958.5
CDK6 -9724.5
CCNE1 -8296.5
TFDP1 -6114.5
CCNE2 -5910.5
E2F2 -4507.5
TFDP2 -4027.5
CDK2 -3570.5
E2F1 -2941.5
CDKN1A 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCND1 -11200.5
CCND3 -11093.5
CDKN1B -10727.5
CCND2 -10505.5
RB1 -10500.5
CDK4 -10143.5
E2F3 -9958.5
CDK6 -9724.5
CCNE1 -8296.5
TFDP1 -6114.5
CCNE2 -5910.5
E2F2 -4507.5
TFDP2 -4027.5
CDK2 -3570.5
E2F1 -2941.5
CDKN1A 0.5


Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)

Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
214
set Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
setSize 16
pANOVA 0.0129
s.dist -0.359
p.adjustANOVA 0.0424



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCND1 -11200.5
CCND3 -11093.5
CDKN1B -10727.5
CCND2 -10505.5
RB1 -10500.5
CDK4 -10143.5
E2F3 -9958.5
CDK6 -9724.5
CCNE1 -8296.5
TFDP1 -6114.5
CCNE2 -5910.5
E2F2 -4507.5
TFDP2 -4027.5
CDK2 -3570.5
E2F1 -2941.5
CDKN1A 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCND1 -11200.5
CCND3 -11093.5
CDKN1B -10727.5
CCND2 -10505.5
RB1 -10500.5
CDK4 -10143.5
E2F3 -9958.5
CDK6 -9724.5
CCNE1 -8296.5
TFDP1 -6114.5
CCNE2 -5910.5
E2F2 -4507.5
TFDP2 -4027.5
CDK2 -3570.5
E2F1 -2941.5
CDKN1A 0.5


Autodegradation of the E3 ubiquitin ligase COP1

Autodegradation of the E3 ubiquitin ligase COP1
72
set Autodegradation of the E3 ubiquitin ligase COP1
setSize 44
pANOVA 4.62e-05
s.dist -0.355
p.adjustANOVA 0.000585



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
TP53 -11286.0
ATM -11206.0
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
UBA52 -8982.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
TP53 -11286.0
ATM -11206.0
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
UBA52 -8982.5
PSMA6 -8827.5
PSMC1 -8768.5
PSMA7 -8735.5
PSME3 -8021.5
PSME1 -7821.5
PSMB10 -7788.5
PSMD14 -7694.5
PSMC6 -7334.5
UBC -7043.5
PSMD3 -6675.5
PSMD8 -6444.5
PSMA1 -6029.5
UBB -5598.5
PSMD1 -4665.5
PSMD9 -4235.5
PSMD11 -3236.5
PSMC4 -2887.5
PSME4 -2566.5
PSMD6 -2202.5
PSMD2 -1784.5
RFWD2 -1443.5
PSMB7 -897.5
PSMB2 0.5
PSMF1 0.5


Lagging Strand Synthesis

Lagging Strand Synthesis
505
set Lagging Strand Synthesis
setSize 17
pANOVA 0.0113
s.dist -0.355
p.adjustANOVA 0.0383



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLA2 -10668.5
RFC2 -9805.5
FEN1 -9524.5
RPA1 -9406.0
PRIM1 -9308.5
POLD4 -9141.5
DNA2 -9113.5
PCNA -8951.5
POLD3 -8818.5
RFC5 -7404.5
RPA3 -7320.5
RFC4 -6979.5
PRIM2 -6221.5
LIG1 -5332.5
RFC3 -4707.5
POLD2 -2749.5
POLD1 -804.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA2 -10668.5
RFC2 -9805.5
FEN1 -9524.5
RPA1 -9406.0
PRIM1 -9308.5
POLD4 -9141.5
DNA2 -9113.5
PCNA -8951.5
POLD3 -8818.5
RFC5 -7404.5
RPA3 -7320.5
RFC4 -6979.5
PRIM2 -6221.5
LIG1 -5332.5
RFC3 -4707.5
POLD2 -2749.5
POLD1 -804.5


Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
169
set Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
setSize 14
pANOVA 0.022
s.dist -0.353
p.adjustANOVA 0.0634



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSP90AA1 -10508.5
RPS27A -9583.5
UBA52 -8982.5
PIK3CA -8638.5
SHC1 -8418.0
PIK3R1 -8408.5
GRB2 -8404.5
CDC37 -8074.0
HRAS -7048.5
UBC -7043.5
KRAS -6376.5
UBB -5598.5
PLCG1 -3691.5
CBL -3075.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSP90AA1 -10508.5
RPS27A -9583.5
UBA52 -8982.5
PIK3CA -8638.5
SHC1 -8418.0
PIK3R1 -8408.5
GRB2 -8404.5
CDC37 -8074.0
HRAS -7048.5
UBC -7043.5
KRAS -6376.5
UBB -5598.5
PLCG1 -3691.5
CBL -3075.5


Signaling by Ligand-Responsive EGFR Variants in Cancer

Signaling by Ligand-Responsive EGFR Variants in Cancer
985
set Signaling by Ligand-Responsive EGFR Variants in Cancer
setSize 14
pANOVA 0.022
s.dist -0.353
p.adjustANOVA 0.0634



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSP90AA1 -10508.5
RPS27A -9583.5
UBA52 -8982.5
PIK3CA -8638.5
SHC1 -8418.0
PIK3R1 -8408.5
GRB2 -8404.5
CDC37 -8074.0
HRAS -7048.5
UBC -7043.5
KRAS -6376.5
UBB -5598.5
PLCG1 -3691.5
CBL -3075.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSP90AA1 -10508.5
RPS27A -9583.5
UBA52 -8982.5
PIK3CA -8638.5
SHC1 -8418.0
PIK3R1 -8408.5
GRB2 -8404.5
CDC37 -8074.0
HRAS -7048.5
UBC -7043.5
KRAS -6376.5
UBB -5598.5
PLCG1 -3691.5
CBL -3075.5


NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
595
set NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
setSize 11
pANOVA 0.0425
s.dist -0.353
p.adjustANOVA 0.105



Top enriched genes

Top 20 genes
GeneID Gene Rank
TRIM25 -11025.5
CASP8 -10911.5
MAVS -9603.5
FADD -9159.5
IFIH1 -8708.5
DDX58 -8094.5
RNF135 -7618.5
IKBKB -6899.5
CASP10 -6031.5
TRIM4 -2596.5
CHUK -944.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRIM25 -11025.5
CASP8 -10911.5
MAVS -9603.5
FADD -9159.5
IFIH1 -8708.5
DDX58 -8094.5
RNF135 -7618.5
IKBKB -6899.5
CASP10 -6031.5
TRIM4 -2596.5
CHUK -944.5


Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)
1042
set Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize 10
pANOVA 0.0532
s.dist 0.353
p.adjustANOVA 0.122



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP4F22 -522.5
GGT1 -774.5
LTC4S -1217.5
PTGR1 -1900.5
ALOX5 -3096.5
ALOX5AP -3188.5
DPEP2 -3811.5
LTA4H -4251.5
ABCC1 -6024.5
MAPKAPK2 -7004.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP4F22 -522.5
GGT1 -774.5
LTC4S -1217.5
PTGR1 -1900.5
ALOX5 -3096.5
ALOX5AP -3188.5
DPEP2 -3811.5
LTA4H -4251.5
ABCC1 -6024.5
MAPKAPK2 -7004.5


ERKs are inactivated

ERKs are inactivated
280
set ERKs are inactivated
setSize 11
pANOVA 0.0436
s.dist -0.351
p.adjustANOVA 0.107



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R5D -10980.5
MAPK7 -10343.5
PPP2CA -10340.5
DUSP3 -9018.5
DUSP7 -8170.5
MAPK1 -8086.5
DUSP4 -6884.5
VRK3 -6448.0
MAPK3 -5132.5
PPP2CB -3533.5
PPP2R1B -2528.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R5D -10980.5
MAPK7 -10343.5
PPP2CA -10340.5
DUSP3 -9018.5
DUSP7 -8170.5
MAPK1 -8086.5
DUSP4 -6884.5
VRK3 -6448.0
MAPK3 -5132.5
PPP2CB -3533.5
PPP2R1B -2528.5


Cross-presentation of soluble exogenous antigens (endosomes)

Cross-presentation of soluble exogenous antigens (endosomes)
176
set Cross-presentation of soluble exogenous antigens (endosomes)
setSize 38
pANOVA 0.000182
s.dist -0.351
p.adjustANOVA 0.00161



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
MRC2 -9697.5
PSMD13 -9682.0
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
PSMA6 -8827.5
PSMC1 -8768.5
PSMA7 -8735.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
MRC2 -9697.5
PSMD13 -9682.0
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
PSMA6 -8827.5
PSMC1 -8768.5
PSMA7 -8735.5
PSME3 -8021.5
PSME1 -7821.5
PSMB10 -7788.5
PSMD14 -7694.5
PSMC6 -7334.5
PSMD3 -6675.5
PSMD8 -6444.5
PSMA1 -6029.5
PSMD1 -4665.5
PSMD9 -4235.5
PSMD11 -3236.5
PSMC4 -2887.5
PSME4 -2566.5
PSMD6 -2202.5
PSMD2 -1784.5
PSMB7 -897.5
PSMB2 0.5
PSMF1 0.5


Cobalamin (Cbl, vitamin B12) transport and metabolism

Cobalamin (Cbl, vitamin B12) transport and metabolism
158
set Cobalamin (Cbl, vitamin B12) transport and metabolism
setSize 11
pANOVA 0.0447
s.dist -0.35
p.adjustANOVA 0.108



Top enriched genes

Top 20 genes
GeneID Gene Rank
MMAB -11063.0
MTR -10517.5
MMACHC -9846.0
MMAA -9022.5
MTRR -8567.5
CD320 -7239.5
ABCD4 -6805.5
LMBRD1 -6796.5
ABCC1 -6024.5
MMADHC -5467.5
LDLRAP1 0.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MMAB -11063.0
MTR -10517.5
MMACHC -9846.0
MMAA -9022.5
MTRR -8567.5
CD320 -7239.5
ABCD4 -6805.5
LMBRD1 -6796.5
ABCC1 -6024.5
MMADHC -5467.5
LDLRAP1 0.5


Ovarian tumor domain proteases

Ovarian tumor domain proteases
665
set Ovarian tumor domain proteases
setSize 29
pANOVA 0.00125
s.dist -0.346
p.adjustANOVA 0.00664



Top enriched genes

Top 20 genes
GeneID Gene Rank
TP53 -11286.0
APC -11252.5
PTEN -11230.5
TRIM25 -11025.5
RHOA -10658.0
TNFAIP3 -10291.5
CDK1 -10144.5
TNIP1 -10006.5
UBE2D1 -9798.5
MAVS -9603.5
RPS27A -9583.5
TNIP2 -9482.5
VCPIP1 -9442.5
UBA52 -8982.5
IFIH1 -8708.5
DDX58 -8094.5
RNF135 -7618.5
OTUB1 -7361.5
OTUD7B -7218.5
UBC -7043.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TP53 -11286.0
APC -11252.5
PTEN -11230.5
TRIM25 -11025.5
RHOA -10658.0
TNFAIP3 -10291.5
CDK1 -10144.5
TNIP1 -10006.5
UBE2D1 -9798.5
MAVS -9603.5
RPS27A -9583.5
TNIP2 -9482.5
VCPIP1 -9442.5
UBA52 -8982.5
IFIH1 -8708.5
DDX58 -8094.5
RNF135 -7618.5
OTUB1 -7361.5
OTUD7B -7218.5
UBC -7043.5
OTUD3 -6307.5
UBB -5598.5
TRAF6 -3105.5
YOD1 -2780.5
TRIM4 -2596.5
TRAF3 -2305.5
NOD1 -1658.5
VCP -602.5
NOD2 0.5


SCF(Skp2)-mediated degradation of p27/p21

SCF(Skp2)-mediated degradation of p27/p21
904
set SCF(Skp2)-mediated degradation of p27/p21
setSize 52
pANOVA 1.71e-05
s.dist -0.345
p.adjustANOVA 0.000287



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
CCND1 -11200.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
CDKN1B -10727.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
CCNA2 -10263.5
CDK4 -10143.5
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
PSMD12 -9232.5
PSMB5 -9216.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB8 -11301.5
PSMB9 -11289.5
CCND1 -11200.5
PSMB1 -11051.0
PSMC5 -11003.0
PSME2 -10839.0
PSMB6 -10828.5
CDKN1B -10727.5
PSMB3 -10632.5
PSMD7 -10467.5
PSMA2 -10358.0
CCNA2 -10263.5
CDK4 -10143.5
PSMD4 -10120.5
PSMA5 -9946.5
PSMA3 -9709.5
PSMD13 -9682.0
RPS27A -9583.5
PSMD12 -9232.5
PSMB5 -9216.5
PSMC3 -9161.5
UBA52 -8982.5
PSMA6 -8827.5
PSMC1 -8768.5
PSMA7 -8735.5
CKS1B -8418.0
CCNE1 -8296.5
PSME3 -8021.5
PSME1 -7821.5
PSMB10 -7788.5
PSMD14 -7694.5
PSMC6 -7334.5
UBC -7043.5
SKP2 -6730.0
PSMD3 -6675.5
PSMD8 -6444.5
PSMA1 -6029.5
CCNE2 -5910.5
UBB -5598.5
SKP1 -4823.5
PSMD1 -4665.5
PSMD9 -4235.5
CDK2 -3570.5
PSMD11 -3236.5
PSMC4 -2887.5
CUL1 -2535.5
PSMD6 -2202.5
PSMD2 -1784.5
PSMB7 -897.5
PSMB2 0.5
PSMF1 0.5
CDKN1A 0.5


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report