Mitch Report

date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##           metric
## PTPRN2 -34.61171
## MAD1L1 -21.46322
## DIP2C  -28.63360
## ATP11A -28.64423
## HDAC4  -21.66308
## SDK1   -24.61224

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2546
num_genes_in_profile	26148
duplicated_genes_present	0
num_profile_genes_in_sets	10252
num_profile_genes_not_in_sets	15896

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1018
num_genesets_included	1528

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
DCC mediated attractive signaling	14	1.31e-05	-0.673	2.22e-04
Activation of RAC1	11	5.22e-04	-0.604	5.08e-03
Regulation of commissural axon pathfinding by SLIT and ROBO	10	2.58e-03	-0.550	1.85e-02
Interaction between L1 and Ankyrins	28	1.43e-06	-0.526	3.78e-05
Apoptotic cleavage of cell adhesion proteins	11	3.15e-03	-0.514	2.12e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	1.35e-03	-0.513	1.07e-02
Nephrin family interactions	21	6.08e-05	-0.505	7.81e-04
Adenylate cyclase activating pathway	10	5.84e-03	-0.503	3.46e-02
NRAGE signals death through JNK	53	3.21e-10	-0.499	2.23e-08
cGMP effects	15	8.81e-04	-0.496	7.57e-03
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	2.99e-03	-0.495	2.05e-02
Defective EXT2 causes exostoses 2	12	2.99e-03	-0.495	2.05e-02
EGR2 and SOX10-mediated initiation of Schwann cell myelination	27	2.19e-05	-0.472	3.42e-04
PKA activation in glucagon signalling	17	7.79e-04	-0.471	6.92e-03
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	1.67e-03	-0.469	1.27e-02
Organic cation transport	10	1.03e-02	-0.468	5.17e-02
Adherens junctions interactions	26	3.81e-05	-0.466	5.11e-04
Role of LAT2/NTAL/LAB on calcium mobilization	13	4.50e-03	-0.455	2.79e-02
Signaling by Hippo	19	6.46e-04	-0.452	6.05e-03
Trafficking of GluR2-containing AMPA receptors	15	3.05e-03	-0.442	2.08e-02
MET activates PTK2 signaling	18	1.20e-03	-0.441	9.66e-03
CRMPs in Sema3A signaling	15	3.15e-03	-0.440	2.12e-02
Biotin transport and metabolism	10	1.62e-02	-0.439	7.16e-02
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	1.99e-04	-0.439	2.12e-03
Interleukin-6 signaling	11	1.21e-02	-0.437	5.82e-02
Nitric oxide stimulates guanylate cyclase	22	3.95e-04	-0.436	4.00e-03
Collagen chain trimerization	42	1.07e-06	-0.435	2.92e-05
VEGFR2 mediated vascular permeability	26	1.29e-04	-0.434	1.49e-03
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14	5.32e-03	-0.430	3.21e-02
Mucopolysaccharidoses	10	1.89e-02	-0.428	8.06e-02
Synthesis of bile acids and bile salts	34	1.55e-05	-0.428	2.54e-04
RND1 GTPase cycle	41	2.74e-06	-0.423	6.55e-05
Adenylate cyclase inhibitory pathway	14	6.51e-03	-0.420	3.71e-02
Defective B3GALTL causes PpS	36	1.40e-05	-0.418	2.36e-04
Non-integrin membrane-ECM interactions	40	4.81e-06	-0.418	1.02e-04
DAG and IP3 signaling	39	7.87e-06	-0.413	1.45e-04
Heme biosynthesis	13	9.88e-03	-0.413	5.03e-02
RORA activates gene expression	17	3.20e-03	-0.413	2.12e-02
PKA-mediated phosphorylation of CREB	19	1.86e-03	-0.412	1.37e-02
Bile acid and bile salt metabolism	45	1.83e-06	-0.411	4.47e-05
RHOU GTPase cycle	37	1.61e-05	-0.410	2.62e-04
Recycling of bile acids and salts	18	2.63e-03	-0.409	1.87e-02
PKA activation	18	2.79e-03	-0.407	1.96e-02
Laminin interactions	23	8.18e-04	-0.403	7.18e-03
O-glycosylation of TSR domain-containing proteins	37	2.42e-05	-0.401	3.58e-04
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	2.14e-02	-0.401	8.78e-02
Collagen biosynthesis and modifying enzymes	65	2.77e-08	-0.398	1.28e-06
Signaling by Leptin	11	2.38e-02	-0.393	9.22e-02
Bicarbonate transporters	10	3.22e-02	-0.391	1.16e-01
Ca-dependent events	35	6.21e-05	-0.391	7.86e-04

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
DCC mediated attractive signaling	14	1.31e-05	-0.673000	2.22e-04
Activation of RAC1	11	5.22e-04	-0.604000	5.08e-03
Regulation of commissural axon pathfinding by SLIT and ROBO	10	2.58e-03	-0.550000	1.85e-02
Interaction between L1 and Ankyrins	28	1.43e-06	-0.526000	3.78e-05
Apoptotic cleavage of cell adhesion proteins	11	3.15e-03	-0.514000	2.12e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	1.35e-03	-0.513000	1.07e-02
Nephrin family interactions	21	6.08e-05	-0.505000	7.81e-04
Adenylate cyclase activating pathway	10	5.84e-03	-0.503000	3.46e-02
NRAGE signals death through JNK	53	3.21e-10	-0.499000	2.23e-08
cGMP effects	15	8.81e-04	-0.496000	7.57e-03
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	2.99e-03	-0.495000	2.05e-02
Defective EXT2 causes exostoses 2	12	2.99e-03	-0.495000	2.05e-02
EGR2 and SOX10-mediated initiation of Schwann cell myelination	27	2.19e-05	-0.472000	3.42e-04
PKA activation in glucagon signalling	17	7.79e-04	-0.471000	6.92e-03
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	1.67e-03	-0.469000	1.27e-02
Organic cation transport	10	1.03e-02	-0.468000	5.17e-02
Adherens junctions interactions	26	3.81e-05	-0.466000	5.11e-04
Role of LAT2/NTAL/LAB on calcium mobilization	13	4.50e-03	-0.455000	2.79e-02
Signaling by Hippo	19	6.46e-04	-0.452000	6.05e-03
Trafficking of GluR2-containing AMPA receptors	15	3.05e-03	-0.442000	2.08e-02
MET activates PTK2 signaling	18	1.20e-03	-0.441000	9.66e-03
CRMPs in Sema3A signaling	15	3.15e-03	-0.440000	2.12e-02
Biotin transport and metabolism	10	1.62e-02	-0.439000	7.16e-02
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	1.99e-04	-0.439000	2.12e-03
Interleukin-6 signaling	11	1.21e-02	-0.437000	5.82e-02
Nitric oxide stimulates guanylate cyclase	22	3.95e-04	-0.436000	4.00e-03
Collagen chain trimerization	42	1.07e-06	-0.435000	2.92e-05
VEGFR2 mediated vascular permeability	26	1.29e-04	-0.434000	1.49e-03
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14	5.32e-03	-0.430000	3.21e-02
Mucopolysaccharidoses	10	1.89e-02	-0.428000	8.06e-02
Synthesis of bile acids and bile salts	34	1.55e-05	-0.428000	2.54e-04
RND1 GTPase cycle	41	2.74e-06	-0.423000	6.55e-05
Adenylate cyclase inhibitory pathway	14	6.51e-03	-0.420000	3.71e-02
Defective B3GALTL causes PpS	36	1.40e-05	-0.418000	2.36e-04
Non-integrin membrane-ECM interactions	40	4.81e-06	-0.418000	1.02e-04
DAG and IP3 signaling	39	7.87e-06	-0.413000	1.45e-04
Heme biosynthesis	13	9.88e-03	-0.413000	5.03e-02
RORA activates gene expression	17	3.20e-03	-0.413000	2.12e-02
PKA-mediated phosphorylation of CREB	19	1.86e-03	-0.412000	1.37e-02
Bile acid and bile salt metabolism	45	1.83e-06	-0.411000	4.47e-05
RHOU GTPase cycle	37	1.61e-05	-0.410000	2.62e-04
Recycling of bile acids and salts	18	2.63e-03	-0.409000	1.87e-02
PKA activation	18	2.79e-03	-0.407000	1.96e-02
Laminin interactions	23	8.18e-04	-0.403000	7.18e-03
O-glycosylation of TSR domain-containing proteins	37	2.42e-05	-0.401000	3.58e-04
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	2.14e-02	-0.401000	8.78e-02
Collagen biosynthesis and modifying enzymes	65	2.77e-08	-0.398000	1.28e-06
Signaling by Leptin	11	2.38e-02	-0.393000	9.22e-02
Bicarbonate transporters	10	3.22e-02	-0.391000	1.16e-01
Ca-dependent events	35	6.21e-05	-0.391000	7.86e-04
TRP channels	24	9.15e-04	-0.391000	7.72e-03
CaM pathway	33	1.09e-04	-0.389000	1.30e-03
Calmodulin induced events	33	1.09e-04	-0.389000	1.30e-03
Negative regulation of NMDA receptor-mediated neuronal transmission	20	2.68e-03	-0.388000	1.90e-02
Effects of PIP2 hydrolysis	26	6.72e-04	-0.385000	6.11e-03
p130Cas linkage to MAPK signaling for integrins	15	9.97e-03	-0.384000	5.05e-02
HS-GAG biosynthesis	28	4.63e-04	-0.382000	4.60e-03
Hormone ligand-binding receptors	13	1.71e-02	-0.382000	7.50e-02
Netrin-1 signaling	49	4.26e-06	-0.379000	9.17e-05
Diseases associated with visual transduction	11	2.98e-02	-0.378000	1.09e-01
Diseases of the neuronal system	11	2.98e-02	-0.378000	1.09e-01
Retinoid cycle disease events	11	2.98e-02	-0.378000	1.09e-01
HDMs demethylate histones	18	6.15e-03	-0.373000	3.57e-02
L1CAM interactions	92	6.94e-10	-0.372000	4.61e-08
Uptake and function of anthrax toxins	11	3.35e-02	-0.370000	1.19e-01
Synthesis of PIPs at the plasma membrane	48	9.32e-06	-0.370000	1.66e-04
Synthesis of PIPs at the early endosome membrane	15	1.32e-02	-0.370000	6.26e-02
RAC1 GTPase cycle	170	9.32e-17	-0.369000	1.78e-14
Collagen formation	88	2.45e-09	-0.368000	1.39e-07
Neurexins and neuroligins	52	5.16e-06	-0.365000	1.08e-04
RND2 GTPase cycle	42	4.28e-05	-0.365000	5.64e-04
Tie2 Signaling	18	7.48e-03	-0.364000	4.07e-02
Crosslinking of collagen fibrils	10	4.66e-02	-0.363000	1.47e-01
MECP2 regulates neuronal receptors and channels	17	9.61e-03	-0.363000	4.96e-02
PLC beta mediated events	47	1.70e-05	-0.362000	2.73e-04
Cell-extracellular matrix interactions	14	1.89e-02	-0.362000	8.06e-02
Reduction of cytosolic Ca++ levels	11	3.83e-02	-0.361000	1.31e-01
SARS-CoV-2 modulates host translation machinery	46	2.35e-05	0.360000	3.55e-04
Viral mRNA Translation	84	1.13e-08	0.360000	5.76e-07
G-protein mediated events	52	7.53e-06	-0.359000	1.42e-04
Phase 2 - plateau phase	14	2.09e-02	-0.356000	8.67e-02
ALK mutants bind TKIs	12	3.26e-02	-0.356000	1.17e-01
CLEC7A (Dectin-1) induces NFAT activation	11	4.13e-02	-0.355000	1.37e-01
G alpha (12/13) signalling events	74	1.40e-07	-0.354000	4.86e-06
Ketone body metabolism	10	5.31e-02	-0.353000	1.58e-01
CDC42 GTPase cycle	144	2.70e-13	-0.352000	2.94e-11
Gap junction degradation	10	5.39e-02	-0.352000	1.58e-01
SUMOylation of immune response proteins	10	5.40e-02	0.352000	1.59e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	2.82e-02	-0.351000	1.06e-01
Peptide chain elongation	84	2.87e-08	0.350000	1.29e-06
Signaling by PDGF	52	1.27e-05	-0.350000	2.19e-04
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	4.48e-02	-0.349000	1.44e-01
Signaling by cytosolic FGFR1 fusion mutants	17	1.32e-02	-0.347000	6.26e-02
Signaling by BMP	27	1.81e-03	-0.347000	1.36e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	3.79e-02	-0.346000	1.30e-01
Carnitine metabolism	11	4.82e-02	-0.344000	1.49e-01
MET promotes cell motility	29	1.35e-03	-0.344000	1.07e-02
Notch-HLH transcription pathway	24	3.55e-03	-0.344000	2.32e-02
Eukaryotic Translation Termination	87	3.19e-08	0.343000	1.35e-06
Intrinsic Pathway of Fibrin Clot Formation	21	6.64e-03	-0.342000	3.77e-02
Cell death signalling via NRAGE, NRIF and NADE	69	9.99e-07	-0.340000	2.83e-05
Eukaryotic Translation Elongation	88	3.39e-08	0.340000	1.36e-06
Selenocysteine synthesis	87	5.18e-08	0.337000	1.98e-06
RHO GTPases activate IQGAPs	11	5.30e-02	-0.337000	1.58e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	2.43e-02	-0.336000	9.38e-02
Unblocking of NMDA receptors, glutamate binding and activation	19	1.13e-02	-0.336000	5.53e-02
Phase 0 - rapid depolarisation	31	1.21e-03	-0.336000	9.70e-03
Assembly and cell surface presentation of NMDA receptors	23	5.61e-03	-0.333000	3.36e-02
Metabolism of porphyrins	27	2.73e-03	-0.333000	1.93e-02
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	3.24e-04	-0.333000	3.36e-03
Sema3A PAK dependent Axon repulsion	14	3.13e-02	-0.332000	1.13e-01
Heme degradation	16	2.22e-02	-0.330000	8.98e-02
Presynaptic nicotinic acetylcholine receptors	12	4.80e-02	0.330000	1.49e-01
Pyrimidine catabolism	12	4.89e-02	-0.328000	1.50e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37	5.48e-04	-0.328000	5.27e-03
Protein-protein interactions at synapses	78	5.51e-07	-0.328000	1.68e-05
Platelet sensitization by LDL	17	2.02e-02	-0.325000	8.50e-02
Assembly of collagen fibrils and other multimeric structures	56	2.60e-05	-0.325000	3.82e-04
Repression of WNT target genes	13	4.30e-02	-0.324000	1.40e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	7.65e-02	-0.323000	2.00e-01
RHOJ GTPase cycle	51	6.88e-05	-0.322000	8.62e-04
Retrograde neurotrophin signalling	14	3.69e-02	-0.322000	1.27e-01
RHOV GTPase cycle	36	8.37e-04	-0.322000	7.30e-03
RHOQ GTPase cycle	57	2.78e-05	-0.321000	4.00e-04
Integrin cell surface interactions	66	6.73e-06	-0.320000	1.30e-04
Synthesis of PIPs at the late endosome membrane	10	7.96e-02	-0.320000	2.03e-01
Fatty acids	15	3.20e-02	0.320000	1.15e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	4.06e-02	-0.316000	1.35e-01
Ion transport by P-type ATPases	51	9.39e-05	-0.316000	1.16e-03
Regulation of signaling by CBL	18	2.05e-02	-0.315000	8.56e-02
Sensory processing of sound	69	6.57e-06	-0.314000	1.30e-04
RHOB GTPase cycle	66	1.16e-05	-0.312000	2.02e-04
Activation of NMDA receptors and postsynaptic events	69	7.67e-06	-0.311000	1.43e-04
RUNX3 regulates NOTCH signaling	13	5.28e-02	-0.310000	1.58e-01
Collagen degradation	39	8.54e-04	-0.308000	7.42e-03
Sensory processing of sound by outer hair cells of the cochlea	49	1.97e-04	-0.307000	2.12e-03
Sensory processing of sound by inner hair cells of the cochlea	62	3.60e-05	-0.303000	4.95e-04
Stimuli-sensing channels	96	2.90e-07	-0.303000	9.63e-06
Recycling pathway of L1	23	1.20e-02	-0.303000	5.77e-02
Phenylalanine and tyrosine metabolism	10	9.82e-02	-0.302000	2.35e-01
Retinoid metabolism and transport	42	7.14e-04	-0.302000	6.42e-03
Extracellular matrix organization	288	1.22e-18	-0.301000	3.11e-16
Beta defensins	32	3.28e-03	0.300000	2.16e-02
RHOA GTPase cycle	140	8.85e-10	-0.300000	5.64e-08
Signaling by BRAF and RAF1 fusions	60	6.23e-05	-0.299000	7.86e-04
HS-GAG degradation	18	2.85e-02	-0.298000	1.06e-01
Formation of a pool of free 40S subunits	95	5.06e-07	0.298000	1.61e-05
ECM proteoglycans	55	1.33e-04	-0.298000	1.53e-03
Abacavir ADME	10	1.03e-01	-0.297000	2.43e-01
Interleukin-15 signaling	13	6.34e-02	-0.297000	1.77e-01
Regulation of KIT signaling	16	3.95e-02	-0.297000	1.33e-01
PECAM1 interactions	12	7.47e-02	-0.297000	1.96e-01
RAF activation	33	3.18e-03	-0.297000	2.12e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	6.39e-07	0.295000	1.88e-05
APC truncation mutants have impaired AXIN binding	13	6.55e-02	-0.295000	1.80e-01
AXIN missense mutants destabilize the destruction complex	13	6.55e-02	-0.295000	1.80e-01
Signaling by AMER1 mutants	13	6.55e-02	-0.295000	1.80e-01
Signaling by APC mutants	13	6.55e-02	-0.295000	1.80e-01
Signaling by AXIN mutants	13	6.55e-02	-0.295000	1.80e-01
Truncations of AMER1 destabilize the destruction complex	13	6.55e-02	-0.295000	1.80e-01
PI Metabolism	79	6.12e-06	-0.294000	1.25e-04
Metallothioneins bind metals	11	9.18e-02	0.294000	2.26e-01
Presynaptic depolarization and calcium channel opening	12	7.85e-02	-0.293000	2.03e-01
Fatty acyl-CoA biosynthesis	35	2.74e-03	-0.292000	1.93e-02
Signaling by WNT in cancer	32	4.24e-03	-0.292000	2.68e-02
CTNNB1 S33 mutants aren’t phosphorylated	14	5.88e-02	-0.292000	1.68e-01
CTNNB1 S37 mutants aren’t phosphorylated	14	5.88e-02	-0.292000	1.68e-01
CTNNB1 S45 mutants aren’t phosphorylated	14	5.88e-02	-0.292000	1.68e-01
CTNNB1 T41 mutants aren’t phosphorylated	14	5.88e-02	-0.292000	1.68e-01
Signaling by CTNNB1 phospho-site mutants	14	5.88e-02	-0.292000	1.68e-01
Signaling by GSK3beta mutants	14	5.88e-02	-0.292000	1.68e-01
Organic cation/anion/zwitterion transport	15	5.06e-02	-0.291000	1.53e-01
Defensins	40	1.50e-03	0.290000	1.17e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	6.93e-03	-0.290000	3.84e-02
Trafficking of AMPA receptors	29	6.93e-03	-0.290000	3.84e-02
Signaling by VEGF	101	5.68e-07	-0.288000	1.70e-05
FCERI mediated Ca+2 mobilization	27	9.79e-03	-0.287000	5.02e-02
Heme signaling	45	8.60e-04	-0.287000	7.42e-03
DSCAM interactions	11	9.94e-02	-0.287000	2.36e-01
SRP-dependent cotranslational protein targeting to membrane	105	3.91e-07	0.286000	1.27e-05
RND3 GTPase cycle	41	1.52e-03	-0.286000	1.18e-02
Signaling by NTRK2 (TRKB)	25	1.33e-02	-0.286000	6.27e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	3.30e-06	0.285000	7.70e-05
NOTCH4 Intracellular Domain Regulates Transcription	19	3.15e-02	-0.285000	1.14e-01
Cell-Cell communication	112	1.90e-07	-0.285000	6.46e-06
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	29	8.00e-03	-0.284000	4.28e-02
Downstream signaling of activated FGFR3	24	1.60e-02	-0.284000	7.16e-02
Post NMDA receptor activation events	58	1.90e-04	-0.283000	2.08e-03
Signaling by PDGFRA extracellular domain mutants	12	8.96e-02	-0.283000	2.22e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	8.96e-02	-0.283000	2.22e-01
CTLA4 inhibitory signaling	21	2.50e-02	-0.283000	9.61e-02
PI-3K cascade:FGFR3	17	4.45e-02	-0.281000	1.44e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	101	1.02e-06	-0.281000	2.84e-05
Post-translational protein phosphorylation	100	1.19e-06	-0.281000	3.18e-05
Glucagon signaling in metabolic regulation	33	5.23e-03	-0.281000	3.17e-02
PKMTs methylate histone lysines	37	3.24e-03	-0.280000	2.14e-02
Scavenging by Class A Receptors	19	3.49e-02	-0.279000	1.23e-01
Sodium/Calcium exchangers	11	1.09e-01	-0.279000	2.50e-01
Cardiac conduction	120	1.35e-07	-0.278000	4.80e-06
The canonical retinoid cycle in rods (twilight vision)	23	2.10e-02	-0.278000	8.67e-02
Formation of the ternary complex, and subsequently, the 43S complex	47	9.81e-04	0.278000	8.19e-03
Myogenesis	29	9.71e-03	-0.277000	4.99e-02
Diseases associated with O-glycosylation of proteins	66	9.75e-05	-0.277000	1.19e-03
TICAM1,TRAF6-dependent induction of TAK1 complex	10	1.30e-01	0.277000	2.80e-01
Sphingolipid de novo biosynthesis	41	2.20e-03	-0.276000	1.60e-02
Thyroxine biosynthesis	10	1.31e-01	-0.276000	2.81e-01
p75 NTR receptor-mediated signalling	89	6.74e-06	-0.276000	1.30e-04
Downstream signal transduction	29	1.02e-02	-0.275000	5.14e-02
Branched-chain amino acid catabolism	20	3.30e-02	-0.275000	1.18e-01
Cell junction organization	79	2.33e-05	-0.275000	3.55e-04
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	12	9.88e-02	-0.275000	2.36e-01
Receptor-type tyrosine-protein phosphatases	16	5.70e-02	-0.275000	1.65e-01
Signal transduction by L1	20	3.35e-02	-0.275000	1.19e-01
Mitotic Telophase/Cytokinesis	10	1.33e-01	-0.274000	2.85e-01
Synthesis of very long-chain fatty acyl-CoAs	23	2.29e-02	-0.274000	9.08e-02
Receptor Mediated Mitophagy	10	1.35e-01	-0.273000	2.87e-01
Lysine catabolism	12	1.03e-01	-0.272000	2.41e-01
Oncogenic MAPK signaling	76	4.08e-05	-0.272000	5.43e-04
Endogenous sterols	26	1.64e-02	-0.272000	7.19e-02
Androgen biosynthesis	11	1.19e-01	-0.272000	2.64e-01
Long-term potentiation	22	2.75e-02	-0.271000	1.04e-01
Synthesis of PC	27	1.46e-02	-0.271000	6.74e-02
EPH-ephrin mediated repulsion of cells	48	1.15e-03	-0.271000	9.44e-03
Ephrin signaling	17	5.37e-02	-0.270000	1.58e-01
Cell-cell junction organization	56	4.67e-04	-0.270000	4.60e-03
Metabolism of fat-soluble vitamins	46	1.51e-03	-0.270000	1.17e-02
Aspartate and asparagine metabolism	12	1.05e-01	-0.270000	2.45e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	1.20e-02	-0.269000	5.78e-02
Activation of the phototransduction cascade	11	1.22e-01	-0.269000	2.70e-01
DARPP-32 events	24	2.26e-02	-0.269000	9.08e-02
O-linked glycosylation	107	1.60e-06	-0.268000	4.07e-05
RHOC GTPase cycle	69	1.20e-04	-0.268000	1.41e-03
Metabolism of cofactors	19	4.36e-02	-0.267000	1.42e-01
Opioid Signalling	88	1.50e-05	-0.267000	2.48e-04
Formation of the beta-catenin:TCF transactivating complex	32	9.02e-03	-0.267000	4.72e-02
Synthesis of PA	35	6.35e-03	-0.266000	3.64e-02
RAC2 GTPase cycle	80	3.78e-05	-0.266000	5.11e-04
Visual phototransduction	93	9.21e-06	-0.266000	1.66e-04
Ion channel transport	168	2.64e-09	-0.266000	1.44e-07
Signaling by KIT in disease	20	3.95e-02	-0.266000	1.33e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	3.95e-02	-0.266000	1.33e-01
FRS-mediated FGFR3 signaling	19	4.48e-02	-0.266000	1.44e-01
Platelet homeostasis	85	2.26e-05	-0.266000	3.48e-04
VEGFA-VEGFR2 Pathway	93	9.35e-06	-0.266000	1.66e-04
rRNA modification in the nucleus and cytosol	55	6.61e-04	0.265000	6.09e-03
Physiological factors	12	1.12e-01	-0.265000	2.56e-01
Signal attenuation	10	1.48e-01	-0.264000	3.03e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	2.24e-02	-0.264000	9.06e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity	26	2.03e-02	-0.263000	8.51e-02
Synthesis of IP3 and IP4 in the cytosol	25	2.30e-02	-0.263000	9.08e-02
Signaling by RAF1 mutants	37	5.71e-03	-0.262000	3.40e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	105	3.44e-06	0.262000	7.84e-05
Voltage gated Potassium channels	42	3.40e-03	-0.261000	2.23e-02
L13a-mediated translational silencing of Ceruloplasmin expression	104	4.21e-06	0.261000	9.17e-05
PD-1 signaling	21	3.85e-02	0.261000	1.31e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	1.04e-01	-0.260000	2.44e-01
Metabolism of steroids	148	4.77e-08	-0.260000	1.87e-06
FCGR3A-mediated IL10 synthesis	37	6.36e-03	-0.259000	3.64e-02
Syndecan interactions	19	5.06e-02	-0.259000	1.53e-01
Degradation of the extracellular matrix	108	3.33e-06	-0.259000	7.70e-05
Interleukin receptor SHC signaling	24	2.85e-02	-0.258000	1.06e-01
VxPx cargo-targeting to cilium	20	4.59e-02	-0.258000	1.45e-01
Apoptotic cleavage of cellular proteins	35	8.28e-03	-0.258000	4.36e-02
RHO GTPase cycle	421	1.11e-19	-0.257000	4.24e-17
Selenoamino acid metabolism	103	6.49e-06	0.257000	1.30e-04
Role of phospholipids in phagocytosis	23	3.33e-02	-0.256000	1.19e-01
E2F mediated regulation of DNA replication	20	4.74e-02	-0.256000	1.49e-01
Elastic fibre formation	41	4.57e-03	-0.256000	2.83e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	14	9.78e-02	-0.255000	2.35e-01
Diseases of hemostasis	14	9.78e-02	-0.255000	2.35e-01
Signaling by FGFR1 in disease	37	7.17e-03	-0.255000	3.94e-02
Phospholipid metabolism	192	1.10e-09	-0.255000	6.71e-08
Downstream signaling of activated FGFR2	29	1.76e-02	-0.255000	7.65e-02
Integrin signaling	27	2.20e-02	-0.255000	8.94e-02
Platelet calcium homeostasis	27	2.25e-02	-0.254000	9.06e-02
NCAM signaling for neurite out-growth	57	9.19e-04	-0.254000	7.72e-03
Paracetamol ADME	30	1.62e-02	-0.254000	7.16e-02
EPHA-mediated growth cone collapse	15	8.90e-02	-0.254000	2.22e-01
Miscellaneous transport and binding events	21	4.44e-02	-0.253000	1.44e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	7.05e-02	-0.253000	1.89e-01
Activation of GABAB receptors	43	4.06e-03	-0.253000	2.59e-02
GABA B receptor activation	43	4.06e-03	-0.253000	2.59e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	9.06e-02	-0.252000	2.24e-01
Signaling by SCF-KIT	43	4.22e-03	-0.252000	2.67e-02
Translocation of ZAP-70 to Immunological synapse	17	7.22e-02	0.252000	1.91e-01
rRNA processing in the nucleus and cytosol	180	5.51e-09	0.252000	2.90e-07
Interaction With Cumulus Cells And The Zona Pellucida	11	1.49e-01	-0.251000	3.05e-01
Signaling by Erythropoietin	25	2.96e-02	-0.251000	1.09e-01
NOTCH2 intracellular domain regulates transcription	11	1.51e-01	-0.250000	3.09e-01
Heparan sulfate/heparin (HS-GAG) metabolism	49	2.50e-03	-0.250000	1.80e-02
Downstream signaling of activated FGFR4	26	2.81e-02	-0.249000	1.06e-01
Phosphorylation of CD3 and TCR zeta chains	20	5.62e-02	0.247000	1.63e-01
tRNA Aminoacylation	24	3.67e-02	-0.246000	1.27e-01
CD28 dependent PI3K/Akt signaling	22	4.57e-02	-0.246000	1.45e-01
Major pathway of rRNA processing in the nucleolus and cytosol	171	2.98e-08	0.245000	1.30e-06
Interleukin-35 Signalling	12	1.42e-01	-0.245000	2.96e-01
Signaling by FGFR3 in disease	21	5.22e-02	-0.245000	1.57e-01
MET receptor recycling	10	1.81e-01	-0.244000	3.50e-01
Acetylcholine binding and downstream events	14	1.13e-01	0.244000	2.57e-01
Postsynaptic nicotinic acetylcholine receptors	14	1.13e-01	0.244000	2.57e-01
Zinc influx into cells by the SLC39 gene family	10	1.81e-01	0.244000	3.50e-01
Mitochondrial tRNA aminoacylation	18	7.35e-02	-0.244000	1.94e-01
PI-3K cascade:FGFR2	22	4.81e-02	-0.243000	1.49e-01
CaMK IV-mediated phosphorylation of CREB	10	1.83e-01	-0.243000	3.53e-01
Molecules associated with elastic fibres	30	2.12e-02	-0.243000	8.75e-02
Defective B3GAT3 causes JDSSDHD	17	8.31e-02	-0.243000	2.10e-01
Free fatty acids regulate insulin secretion	10	1.84e-01	-0.243000	3.54e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	1.46e-01	-0.242000	3.01e-01
Defective B4GALT7 causes EDS, progeroid type	17	8.39e-02	-0.242000	2.12e-01
rRNA processing	186	1.35e-08	0.241000	6.64e-07
MET activates RAP1 and RAC1	11	1.68e-01	-0.240000	3.31e-01
ABC transporters in lipid homeostasis	17	8.70e-02	-0.240000	2.19e-01
Signaling by NOTCH1	70	5.51e-04	-0.239000	5.27e-03
PI3K events in ERBB2 signaling	16	9.84e-02	-0.239000	2.35e-01
Glucuronidation	25	3.96e-02	-0.238000	1.33e-01
Activated NOTCH1 Transmits Signal to the Nucleus	31	2.20e-02	-0.238000	8.94e-02
GABA receptor activation	57	1.94e-03	-0.237000	1.42e-02
NCAM1 interactions	36	1.38e-02	-0.237000	6.46e-02
Activation of gene expression by SREBF (SREBP)	42	8.35e-03	-0.235000	4.38e-02
Muscle contraction	186	3.37e-08	-0.234000	1.36e-06
FRS-mediated FGFR2 signaling	24	4.70e-02	-0.234000	1.48e-01
Signaling by FGFR4 in disease	11	1.79e-01	-0.234000	3.48e-01
PI-3K cascade:FGFR4	19	7.79e-02	-0.234000	2.02e-01
Beta-catenin phosphorylation cascade	16	1.06e-01	-0.233000	2.46e-01
Ras activation upon Ca2+ influx through NMDA receptor	19	7.85e-02	-0.233000	2.03e-01
Inositol phosphate metabolism	45	6.83e-03	-0.233000	3.84e-02
Signaling by PDGFR in disease	20	7.15e-02	-0.233000	1.90e-01
Lewis blood group biosynthesis	18	8.75e-02	-0.233000	2.20e-01
Defects in vitamin and cofactor metabolism	20	7.21e-02	-0.232000	1.91e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	1.19e-01	-0.232000	2.66e-01
Transport of Mature mRNA Derived from an Intronless Transcript	40	1.13e-02	-0.231000	5.53e-02
Other semaphorin interactions	18	8.97e-02	-0.231000	2.22e-01
RHOG GTPase cycle	69	9.06e-04	-0.231000	7.69e-03
Assembly of the ORC complex at the origin of replication	10	2.07e-01	-0.231000	3.83e-01
SHC1 events in ERBB2 signaling	22	6.14e-02	-0.230000	1.73e-01
Kinesins	42	9.81e-03	-0.230000	5.02e-02
Transcriptional Regulation by MECP2	60	2.04e-03	-0.230000	1.49e-02
Activation of AMPK downstream of NMDARs	10	2.08e-01	-0.230000	3.83e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	2.95e-02	-0.230000	1.09e-01
FGFR1 mutant receptor activation	30	2.96e-02	-0.229000	1.09e-01
SLBP independent Processing of Histone Pre-mRNAs	10	2.09e-01	-0.229000	3.83e-01
FGFR2b ligand binding and activation	10	2.09e-01	-0.229000	3.83e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	1.13e-02	-0.228000	5.53e-02
Transport of Mature mRNAs Derived from Intronless Transcripts	41	1.14e-02	-0.228000	5.55e-02
Ribosomal scanning and start codon recognition	54	3.78e-03	0.228000	2.45e-02
PPARA activates gene expression	114	2.69e-05	-0.227000	3.91e-04
Signaling by high-kinase activity BRAF mutants	32	2.62e-02	-0.227000	9.94e-02
Signaling by FGFR2 IIIa TM	19	8.75e-02	-0.226000	2.20e-01
Pexophagy	11	1.94e-01	0.226000	3.66e-01
Cap-dependent Translation Initiation	112	3.52e-05	0.226000	4.89e-04
Eukaryotic Translation Initiation	112	3.52e-05	0.226000	4.89e-04
Signaling by MET	66	1.48e-03	-0.226000	1.16e-02
RHOD GTPase cycle	49	6.25e-03	-0.226000	3.61e-02
APC/C:Cdc20 mediated degradation of Cyclin B	24	5.59e-02	0.225000	1.62e-01
Glycerophospholipid biosynthesis	114	3.25e-05	-0.225000	4.64e-04
HuR (ELAVL1) binds and stabilizes mRNA	10	2.18e-01	-0.225000	3.92e-01
GPER1 signaling	44	9.90e-03	-0.225000	5.03e-02
Ion homeostasis	50	6.08e-03	-0.224000	3.57e-02
FRS-mediated FGFR4 signaling	21	7.56e-02	-0.224000	1.98e-01
Signaling by CSF3 (G-CSF)	28	4.03e-02	-0.224000	1.34e-01
Neuronal System	371	1.26e-13	-0.224000	1.61e-11
Interleukin-27 signaling	11	2.00e-01	-0.223000	3.74e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	5.34e-02	-0.223000	1.58e-01
NOTCH3 Intracellular Domain Regulates Transcription	24	5.87e-02	-0.223000	1.68e-01
RMTs methylate histone arginines	29	3.82e-02	-0.222000	1.31e-01
NR1H2 and NR1H3-mediated signaling	53	5.14e-03	-0.222000	3.14e-02
APC-Cdc20 mediated degradation of Nek2A	26	5.02e-02	0.222000	1.53e-01
Regulation of lipid metabolism by PPARalpha	116	3.67e-05	-0.222000	5.01e-04
Nucleotide catabolism	35	2.32e-02	-0.222000	9.08e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	117	3.46e-05	-0.221000	4.89e-04
Drug ADME	98	1.52e-04	-0.221000	1.70e-03
Listeria monocytogenes entry into host cells	19	9.60e-02	-0.221000	2.32e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	1.45e-02	-0.221000	6.72e-02
Signaling by FGFR in disease	61	2.95e-03	-0.220000	2.04e-02
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	52	6.14e-03	-0.220000	3.57e-02
Neurotransmitter receptors and postsynaptic signal transmission	175	5.50e-07	-0.219000	1.68e-05
Nicotinamide salvaging	17	1.18e-01	-0.219000	2.63e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	1.52e-02	-0.219000	6.89e-02
Signaling by RAS mutants	41	1.52e-02	-0.219000	6.89e-02
Signaling by moderate kinase activity BRAF mutants	41	1.52e-02	-0.219000	6.89e-02
Signaling downstream of RAS mutants	41	1.52e-02	-0.219000	6.89e-02
Disorders of Developmental Biology	11	2.09e-01	-0.219000	3.83e-01
Disorders of Nervous System Development	11	2.09e-01	-0.219000	3.83e-01
Loss of function of MECP2 in Rett syndrome	11	2.09e-01	-0.219000	3.83e-01
Pervasive developmental disorders	11	2.09e-01	-0.219000	3.83e-01
Vitamin D (calciferol) metabolism	12	1.90e-01	-0.219000	3.62e-01
Regulation of TP53 Activity through Association with Co-factors	14	1.57e-01	-0.219000	3.17e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	2.11e-01	-0.218000	3.85e-01
MAPK3 (ERK1) activation	10	2.33e-01	-0.218000	4.10e-01
p75NTR signals via NF-kB	15	1.45e-01	0.218000	2.99e-01
Antimicrobial peptides	82	6.57e-04	0.218000	6.09e-03
Activation of BH3-only proteins	30	3.92e-02	-0.217000	1.33e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	604	5.60e-20	-0.217000	2.85e-17
IGF1R signaling cascade	51	7.25e-03	-0.217000	3.97e-02
IRS-related events triggered by IGF1R	50	7.86e-03	-0.217000	4.21e-02
Signaling by Rho GTPases	590	1.86e-19	-0.217000	5.67e-17
SLC transporter disorders	92	3.28e-04	-0.217000	3.39e-03
Transport of Ribonucleoproteins into the Host Nucleus	30	4.01e-02	-0.216000	1.34e-01
Interleukin-20 family signaling	25	6.13e-02	-0.216000	1.73e-01
Phospholipase C-mediated cascade; FGFR3	12	1.96e-01	-0.216000	3.69e-01
Chondroitin sulfate biosynthesis	18	1.15e-01	-0.215000	2.59e-01
Fcgamma receptor (FCGR) dependent phagocytosis	82	7.76e-04	-0.215000	6.92e-03
LDL clearance	19	1.06e-01	-0.214000	2.46e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	1.53e-01	-0.213000	3.11e-01
O-linked glycosylation of mucins	62	3.70e-03	-0.213000	2.40e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	6.75e-03	-0.213000	3.81e-02
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	41	1.82e-02	-0.213000	7.83e-02
Integration of energy metabolism	106	1.51e-04	-0.213000	1.70e-03
Negative regulation of MET activity	20	9.97e-02	-0.213000	2.37e-01
RET signaling	41	1.86e-02	-0.212000	7.95e-02
RUNX2 regulates bone development	29	4.77e-02	-0.212000	1.49e-01
Semaphorin interactions	61	4.12e-03	-0.212000	2.63e-02
SUMOylation of intracellular receptors	29	4.78e-02	-0.212000	1.49e-01
DNA Double Strand Break Response	42	1.76e-02	-0.212000	7.65e-02
RHOF GTPase cycle	40	2.06e-02	-0.211000	8.56e-02
Translation initiation complex formation	54	7.32e-03	0.211000	3.99e-02
CD209 (DC-SIGN) signaling	20	1.05e-01	-0.209000	2.44e-01
p75NTR recruits signalling complexes	12	2.10e-01	0.209000	3.84e-01
Diseases of glycosylation	137	2.40e-05	-0.209000	3.58e-04
Constitutive Signaling by EGFRvIII	15	1.62e-01	-0.209000	3.23e-01
Signaling by EGFRvIII in Cancer	15	1.62e-01	-0.209000	3.23e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	15	1.62e-01	-0.208000	3.23e-01
Metabolism of lipids	696	5.27e-21	-0.208000	4.03e-18
Intraflagellar transport	36	3.09e-02	-0.208000	1.12e-01
NF-kB is activated and signals survival	12	2.13e-01	0.208000	3.87e-01
FGFR3 mutant receptor activation	11	2.35e-01	-0.207000	4.13e-01
Signaling by activated point mutants of FGFR3	11	2.35e-01	-0.207000	4.13e-01
Regulation of FZD by ubiquitination	21	1.01e-01	-0.207000	2.39e-01
STAT5 activation downstream of FLT3 ITD mutants	10	2.59e-01	-0.206000	4.41e-01
FGFR2c ligand binding and activation	12	2.16e-01	-0.206000	3.90e-01
Smooth Muscle Contraction	39	2.60e-02	-0.206000	9.90e-02
CASP8 activity is inhibited	11	2.38e-01	0.206000	4.15e-01
Dimerization of procaspase-8	11	2.38e-01	0.206000	4.15e-01
Regulation by c-FLIP	11	2.38e-01	0.206000	4.15e-01
Negative regulation of the PI3K/AKT network	111	1.81e-04	-0.206000	1.99e-03
EML4 and NUDC in mitotic spindle formation	93	6.12e-04	-0.205000	5.81e-03
Azathioprine ADME	22	9.53e-02	-0.205000	2.32e-01
Blood group systems biosynthesis	22	9.58e-02	-0.205000	2.32e-01
G alpha (z) signalling events	48	1.41e-02	-0.205000	6.57e-02
Triglyceride catabolism	23	8.95e-02	-0.204000	2.22e-01
PI3K Cascade	43	2.04e-02	-0.204000	8.52e-02
Activation of BAD and translocation to mitochondria	15	1.71e-01	-0.204000	3.34e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	1.45e-01	0.204000	3.00e-01
The phototransduction cascade	32	4.58e-02	-0.204000	1.45e-01
CD28 co-stimulation	32	4.64e-02	-0.203000	1.47e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	42	2.26e-02	-0.203000	9.08e-02
Chromatin modifying enzymes	185	1.84e-06	-0.203000	4.47e-05
Chromatin organization	185	1.84e-06	-0.203000	4.47e-05
Activation of HOX genes during differentiation	61	6.10e-03	-0.203000	3.57e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis	61	6.10e-03	-0.203000	3.57e-02
Hh mutants are degraded by ERAD	54	1.02e-02	0.202000	5.14e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	38	3.11e-02	-0.202000	1.13e-01
Potassium Channels	102	4.35e-04	-0.201000	4.37e-03
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	1.77e-01	-0.201000	3.45e-01
Energy dependent regulation of mTOR by LKB1-AMPK	28	6.54e-02	-0.201000	1.80e-01
ERBB2 Activates PTK6 Signaling	13	2.12e-01	-0.200000	3.87e-01
FGFR3 ligand binding and activation	12	2.31e-01	-0.200000	4.08e-01
FGFR3c ligand binding and activation	12	2.31e-01	-0.200000	4.08e-01
IRS-mediated signalling	47	1.82e-02	-0.199000	7.82e-02
Transmission across Chemical Synapses	237	1.25e-07	-0.199000	4.56e-06
Hh mutants abrogate ligand secretion	57	9.50e-03	0.199000	4.92e-02
SUMOylation of chromatin organization proteins	54	1.16e-02	-0.198000	5.63e-02
Aspirin ADME	44	2.28e-02	-0.198000	9.08e-02
Inactivation of CSF3 (G-CSF) signaling	23	1.01e-01	-0.198000	2.37e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	55	1.12e-02	0.198000	5.53e-02
Reactions specific to the complex N-glycan synthesis pathway	10	2.79e-01	-0.197000	4.64e-01
EPH-Ephrin signaling	90	1.20e-03	-0.197000	9.68e-03
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	4.28e-03	0.196000	2.68e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	6.35e-02	-0.196000	1.77e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	6.35e-02	-0.196000	1.77e-01
Triglyceride metabolism	36	4.24e-02	-0.195000	1.40e-01
PI3K/AKT Signaling in Cancer	103	6.16e-04	-0.195000	5.81e-03
Transcriptional regulation of granulopoiesis	31	6.00e-02	-0.195000	1.71e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	2.42e-01	-0.195000	4.19e-01
alpha-linolenic acid (ALA) metabolism	12	2.42e-01	-0.195000	4.19e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	4.26e-03	0.195000	2.68e-02
Signaling by ALK fusions and activated point mutants	51	1.62e-02	-0.195000	7.16e-02
Signaling by ALK in cancer	51	1.62e-02	-0.195000	7.16e-02
Sphingolipid metabolism	81	2.46e-03	-0.195000	1.78e-02
Ca2+ pathway	62	8.06e-03	-0.194000	4.28e-02
Rev-mediated nuclear export of HIV RNA	33	5.32e-02	-0.194000	1.58e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	74	3.95e-03	0.194000	2.55e-02
RHO GTPases activate PAKs	19	1.44e-01	-0.194000	2.99e-01
Insulin receptor signalling cascade	53	1.51e-02	-0.193000	6.89e-02
APC/C:Cdc20 mediated degradation of Securin	66	6.73e-03	0.193000	3.81e-02
Activated NTRK2 signals through FRS2 and FRS3	11	2.69e-01	-0.193000	4.52e-01
Beta-oxidation of very long chain fatty acids	10	2.92e-01	-0.192000	4.80e-01
Formation of Fibrin Clot (Clotting Cascade)	37	4.32e-02	-0.192000	1.41e-01
Eicosanoids	12	2.51e-01	0.191000	4.31e-01
Regulation of MECP2 expression and activity	30	6.94e-02	-0.191000	1.87e-01
Inactivation, recovery and regulation of the phototransduction cascade	31	6.52e-02	-0.191000	1.80e-01
MTOR signalling	40	3.65e-02	-0.191000	1.26e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	89	1.86e-03	-0.191000	1.37e-02
Amplification of signal from the kinetochores	89	1.86e-03	-0.191000	1.37e-02
Synaptic adhesion-like molecules	19	1.52e-01	-0.190000	3.10e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	108	6.65e-04	0.189000	6.09e-03
Nonsense-Mediated Decay (NMD)	108	6.65e-04	0.189000	6.09e-03
InlB-mediated entry of Listeria monocytogenes into host cell	14	2.20e-01	-0.189000	3.95e-01
Vasopressin regulates renal water homeostasis via Aquaporins	42	3.40e-02	-0.189000	1.20e-01
RAB GEFs exchange GTP for GDP on RABs	83	2.95e-03	-0.189000	2.04e-02
Apoptotic execution phase	43	3.26e-02	-0.188000	1.17e-01
RAC3 GTPase cycle	84	2.85e-03	-0.188000	1.99e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	2.59e-01	-0.188000	4.41e-01
Signaling by FLT3 ITD and TKD mutants	16	1.93e-01	-0.188000	3.65e-01
Formation of apoptosome	10	3.04e-01	0.188000	4.88e-01
Regulation of the apoptosome activity	10	3.04e-01	0.188000	4.88e-01
Platelet degranulation	116	4.84e-04	-0.187000	4.74e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	5.02e-03	0.187000	3.10e-02
Sialic acid metabolism	33	6.35e-02	-0.187000	1.77e-01
Signaling by FGFR2 in disease	42	3.63e-02	-0.187000	1.26e-01
GPVI-mediated activation cascade	32	6.80e-02	-0.186000	1.84e-01
G alpha (q) signalling events	206	4.02e-06	-0.186000	8.89e-05
COPI-independent Golgi-to-ER retrograde traffic	34	6.03e-02	-0.186000	1.71e-01
Inflammasomes	21	1.40e-01	-0.186000	2.94e-01
Signaling by FLT3 fusion proteins	19	1.60e-01	-0.186000	3.22e-01
LGI-ADAM interactions	14	2.28e-01	0.186000	4.07e-01
Phospholipase C-mediated cascade; FGFR2	17	1.85e-01	-0.186000	3.55e-01
Interactions of Vpr with host cellular proteins	33	6.48e-02	-0.186000	1.80e-01
Circadian Clock	69	7.66e-03	-0.186000	4.14e-02
Transcriptional regulation of pluripotent stem cells	30	7.93e-02	-0.185000	2.03e-01
Insulin processing	26	1.02e-01	-0.185000	2.41e-01
Deadenylation of mRNA	25	1.09e-01	-0.185000	2.50e-01
SUMOylation of ubiquitinylation proteins	37	5.15e-02	-0.185000	1.55e-01
FCGR3A-mediated phagocytosis	57	1.57e-02	-0.185000	7.05e-02
Leishmania phagocytosis	57	1.57e-02	-0.185000	7.05e-02
Parasite infection	57	1.57e-02	-0.185000	7.05e-02
E3 ubiquitin ligases ubiquitinate target proteins	43	3.58e-02	-0.185000	1.25e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	1.42e-01	0.185000	2.96e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	1.42e-01	0.185000	2.96e-01
NS1 Mediated Effects on Host Pathways	39	4.57e-02	-0.185000	1.45e-01
Alpha-protein kinase 1 signaling pathway	10	3.11e-01	0.185000	4.97e-01
Regulation of IFNA/IFNB signaling	24	1.17e-01	0.185000	2.62e-01
MAP2K and MAPK activation	36	5.51e-02	-0.185000	1.61e-01
Signaling by EGFR	49	2.55e-02	-0.184000	9.75e-02
Regulation of expression of SLITs and ROBOs	159	6.02e-05	0.184000	7.80e-04
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	104	1.18e-03	-0.184000	9.57e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	2.06e-02	0.184000	8.56e-02
Cargo trafficking to the periciliary membrane	49	2.66e-02	-0.183000	1.00e-01
TNFR1-induced NFkappaB signaling pathway	22	1.38e-01	-0.182000	2.92e-01
Death Receptor Signalling	129	3.48e-04	-0.182000	3.55e-03
Signaling by ERBB2 ECD mutants	15	2.22e-01	-0.182000	3.96e-01
Resolution of Sister Chromatid Cohesion	98	1.83e-03	-0.182000	1.37e-02
Regulation of pyruvate dehydrogenase (PDH) complex	14	2.40e-01	-0.181000	4.17e-01
EPHB-mediated forward signaling	34	6.77e-02	-0.181000	1.84e-01
Chondroitin sulfate/dermatan sulfate metabolism	45	3.61e-02	-0.181000	1.25e-01
Elevation of cytosolic Ca2+ levels	16	2.12e-01	-0.180000	3.87e-01
GPCR downstream signalling	604	3.74e-14	-0.180000	5.19e-12
Condensation of Prometaphase Chromosomes	11	3.02e-01	0.180000	4.88e-01
A tetrasaccharide linker sequence is required for GAG synthesis	23	1.36e-01	-0.179000	2.89e-01
Cellular response to starvation	147	1.72e-04	0.179000	1.91e-03
Nonhomologous End-Joining (NHEJ)	32	7.92e-02	-0.179000	2.03e-01
Eicosanoid ligand-binding receptors	14	2.46e-01	-0.179000	4.23e-01
Serotonin Neurotransmitter Release Cycle	16	2.15e-01	-0.179000	3.89e-01
Triglyceride biosynthesis	13	2.64e-01	-0.179000	4.47e-01
Interactions of Rev with host cellular proteins	35	6.70e-02	-0.179000	1.83e-01
Nucleotide-like (purinergic) receptors	13	2.64e-01	-0.179000	4.47e-01
Influenza Viral RNA Transcription and Replication	129	4.52e-04	0.179000	4.51e-03
Signal Transduction	2408	1.48e-47	-0.178000	2.26e-44
NOTCH1 Intracellular Domain Regulates Transcription	44	4.04e-02	-0.178000	1.35e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	20	1.67e-01	-0.178000	3.30e-01
Vitamin B5 (pantothenate) metabolism	16	2.16e-01	-0.178000	3.90e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	2.33e-02	-0.178000	9.08e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	2.33e-02	-0.178000	9.08e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	2.33e-02	-0.178000	9.08e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	2.33e-02	-0.178000	9.08e-02
Signaling by NOTCH1 in Cancer	54	2.33e-02	-0.178000	9.08e-02
Activated point mutants of FGFR2	16	2.19e-01	-0.178000	3.92e-01
Sensory perception of taste	47	3.57e-02	-0.177000	1.25e-01
Signaling by Receptor Tyrosine Kinases	492	1.65e-11	-0.177000	1.49e-09
Diseases associated with glycosaminoglycan metabolism	38	5.93e-02	-0.177000	1.69e-01
Interleukin-2 family signaling	40	5.31e-02	-0.177000	1.58e-01
Transport of the SLBP independent Mature mRNA	33	7.96e-02	-0.176000	2.03e-01
Acyl chain remodelling of PC	26	1.20e-01	-0.176000	2.67e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	2.38e-01	-0.176000	4.15e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	2.38e-01	-0.176000	4.15e-01
ATF6 (ATF6-alpha) activates chaperones	11	3.13e-01	-0.176000	4.98e-01
SHC-mediated cascade:FGFR3	17	2.10e-01	-0.176000	3.84e-01
Inwardly rectifying K+ channels	35	7.32e-02	-0.175000	1.93e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27	1.16e-01	-0.175000	2.60e-01
Constitutive Signaling by Aberrant PI3K in Cancer	77	8.06e-03	-0.175000	4.28e-02
SARS-CoV-2 modulates autophagy	11	3.16e-01	-0.174000	4.99e-01
Prolonged ERK activation events	14	2.59e-01	-0.174000	4.41e-01
Response to metal ions	14	2.59e-01	0.174000	4.41e-01
Transport of the SLBP Dependant Mature mRNA	34	7.88e-02	-0.174000	2.03e-01
Hyaluronan uptake and degradation	12	2.96e-01	-0.174000	4.83e-01
CDK-mediated phosphorylation and removal of Cdc6	71	1.12e-02	0.174000	5.53e-02
Binding and Uptake of Ligands by Scavenger Receptors	41	5.37e-02	-0.174000	1.58e-01
NEP/NS2 Interacts with the Cellular Export Machinery	30	9.88e-02	-0.174000	2.36e-01
HCMV Early Events	55	2.58e-02	-0.174000	9.83e-02
Signaling by ALK	26	1.26e-01	-0.173000	2.76e-01
Transcriptional regulation of testis differentiation	12	3.00e-01	0.173000	4.86e-01
Pre-NOTCH Transcription and Translation	45	4.51e-02	-0.173000	1.44e-01
Citric acid cycle (TCA cycle)	21	1.71e-01	-0.172000	3.35e-01
Activation of G protein gated Potassium channels	29	1.08e-01	-0.172000	2.49e-01
G protein gated Potassium channels	29	1.08e-01	-0.172000	2.49e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	29	1.08e-01	-0.172000	2.49e-01
Mitochondrial biogenesis	69	1.33e-02	-0.172000	6.26e-02
Transport of small molecules	689	1.10e-14	-0.172000	1.86e-12
Regulation of IFNG signaling	14	2.65e-01	-0.172000	4.47e-01
Extra-nuclear estrogen signaling	73	1.10e-02	-0.172000	5.50e-02
Polo-like kinase mediated events	16	2.34e-01	-0.172000	4.12e-01
Response to elevated platelet cytosolic Ca2+	121	1.11e-03	-0.172000	9.16e-03
Deposition of new CENPA-containing nucleosomes at the centromere	26	1.30e-01	-0.171000	2.80e-01
Nucleosome assembly	26	1.30e-01	-0.171000	2.80e-01
Pyrimidine salvage	10	3.48e-01	0.171000	5.34e-01
Nuclear Pore Complex (NPC) Disassembly	34	8.38e-02	-0.171000	2.12e-01
Platelet activation, signaling and aggregation	246	3.61e-06	-0.171000	8.12e-05
Vpr-mediated nuclear import of PICs	32	9.35e-02	-0.171000	2.29e-01
Zinc transporters	17	2.22e-01	0.171000	3.96e-01
G alpha (s) signalling events	153	2.58e-04	-0.171000	2.72e-03
VEGFR2 mediated cell proliferation	19	1.98e-01	-0.170000	3.72e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	4.11e-02	0.170000	1.36e-01
Platelet Adhesion to exposed collagen	13	2.88e-01	-0.170000	4.75e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	3.58e-02	-0.170000	1.25e-01
p38MAPK events	13	2.89e-01	0.170000	4.77e-01
Signaling by Non-Receptor Tyrosine Kinases	55	2.99e-02	-0.169000	1.09e-01
Signaling by PTK6	55	2.99e-02	-0.169000	1.09e-01
Organelle biogenesis and maintenance	243	5.67e-06	-0.169000	1.17e-04
Signaling by NTRK3 (TRKC)	17	2.29e-01	-0.169000	4.07e-01
Regulation of insulin secretion	77	1.05e-02	-0.169000	5.25e-02
GRB2 events in ERBB2 signaling	16	2.44e-01	-0.168000	4.20e-01
Keratan sulfate degradation	12	3.14e-01	-0.168000	4.99e-01
Diseases of metabolism	234	1.01e-05	-0.167000	1.78e-04
Metabolism of vitamins and cofactors	181	1.03e-04	-0.167000	1.25e-03
Autodegradation of Cdh1 by Cdh1:APC/C	62	2.28e-02	0.167000	9.08e-02
Trafficking and processing of endosomal TLR	11	3.38e-01	0.167000	5.23e-01
Cilium Assembly	174	1.49e-04	-0.167000	1.70e-03
Signaling by ERBB2 KD Mutants	24	1.58e-01	-0.167000	3.19e-01
Pentose phosphate pathway	12	3.19e-01	-0.166000	5.00e-01
FOXO-mediated transcription of cell death genes	15	2.66e-01	-0.166000	4.49e-01
SCF(Skp2)-mediated degradation of p27/p21	58	2.92e-02	0.165000	1.09e-01
Processing of Intronless Pre-mRNAs	19	2.13e-01	-0.165000	3.87e-01
Erythrocytes take up carbon dioxide and release oxygen	12	3.24e-01	-0.165000	5.05e-01
O2/CO2 exchange in erythrocytes	12	3.24e-01	-0.165000	5.05e-01
Signaling by NOTCH3	48	4.88e-02	-0.164000	1.50e-01
RNA Polymerase III Abortive And Retractive Initiation	41	6.88e-02	-0.164000	1.86e-01
RNA Polymerase III Transcription	41	6.88e-02	-0.164000	1.86e-01
WNT5A-dependent internalization of FZD4	15	2.71e-01	-0.164000	4.55e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	1.60e-02	0.164000	7.16e-02
Maturation of nucleoprotein	11	3.47e-01	-0.164000	5.33e-01
Autodegradation of the E3 ubiquitin ligase COP1	50	4.57e-02	0.163000	1.45e-01
Intra-Golgi traffic	43	6.41e-02	-0.163000	1.79e-01
Antigen processing: Ubiquitination & Proteasome degradation	293	1.60e-06	-0.163000	4.07e-05
FCERI mediated MAPK activation	29	1.30e-01	-0.162000	2.80e-01
Mitochondrial Fatty Acid Beta-Oxidation	35	9.67e-02	-0.162000	2.33e-01
Nuclear signaling by ERBB4	32	1.13e-01	-0.162000	2.56e-01
SHC-mediated cascade:FGFR2	22	1.89e-01	-0.162000	3.62e-01
Signaling by Nuclear Receptors	237	1.81e-05	-0.161000	2.87e-04
Vpu mediated degradation of CD4	50	4.84e-02	0.161000	1.49e-01
Metabolism of steroid hormones	33	1.09e-01	-0.161000	2.50e-01
SLC-mediated transmembrane transport	238	1.82e-05	-0.161000	2.87e-04
Regulation of ornithine decarboxylase (ODC)	49	5.11e-02	0.161000	1.54e-01
Early Phase of HIV Life Cycle	14	2.98e-01	0.161000	4.84e-01
Peroxisomal lipid metabolism	28	1.41e-01	-0.161000	2.95e-01
Vif-mediated degradation of APOBEC3G	50	4.98e-02	0.160000	1.52e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	44	6.57e-02	-0.160000	1.80e-01
Diseases of signal transduction by growth factor receptors and second messengers	410	2.43e-08	-0.160000	1.16e-06
G beta:gamma signalling through PI3Kgamma	25	1.66e-01	-0.160000	3.30e-01
Hemostasis	560	8.42e-11	-0.160000	6.77e-09
Phospholipase C-mediated cascade; FGFR4	14	3.00e-01	-0.160000	4.86e-01
SUMOylation of DNA damage response and repair proteins	71	1.98e-02	-0.160000	8.40e-02
FOXO-mediated transcription	65	2.58e-02	-0.160000	9.83e-02
Rab regulation of trafficking	114	3.18e-03	-0.160000	2.12e-02
The role of Nef in HIV-1 replication and disease pathogenesis	27	1.52e-01	-0.159000	3.10e-01
Vesicle-mediated transport	624	9.92e-12	-0.159000	9.48e-10
Interleukin-37 signaling	21	2.07e-01	-0.159000	3.83e-01
Nuclear Envelope Breakdown	50	5.34e-02	-0.158000	1.58e-01
Acetylcholine regulates insulin secretion	10	3.87e-01	-0.158000	5.75e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	3.87e-01	-0.158000	5.75e-01
UCH proteinases	81	1.42e-02	0.157000	6.64e-02
ERBB2 Regulates Cell Motility	15	2.91e-01	-0.157000	4.79e-01
eNOS activation	11	3.67e-01	-0.157000	5.54e-01
Membrane Trafficking	586	8.28e-11	-0.157000	6.77e-09
Regulation of localization of FOXO transcription factors	11	3.69e-01	-0.156000	5.57e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	120	3.14e-03	0.156000	2.12e-02
Processing of Capped Intronless Pre-mRNA	28	1.54e-01	-0.156000	3.13e-01
Diseases of carbohydrate metabolism	30	1.40e-01	-0.155000	2.94e-01
RNA Polymerase III Transcription Initiation	36	1.07e-01	-0.155000	2.47e-01
FGFR2 mutant receptor activation	32	1.28e-01	-0.155000	2.79e-01
Metalloprotease DUBs	19	2.42e-01	-0.155000	4.19e-01
Dopamine Neurotransmitter Release Cycle	20	2.30e-01	-0.155000	4.07e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	43	7.90e-02	-0.155000	2.03e-01
Signaling by GPCR	671	7.52e-12	-0.155000	7.66e-10
Gene Silencing by RNA	80	1.74e-02	-0.154000	7.58e-02
The NLRP3 inflammasome	16	2.87e-01	-0.154000	4.74e-01
Incretin synthesis, secretion, and inactivation	23	2.02e-01	-0.153000	3.77e-01
Glycosaminoglycan metabolism	116	4.31e-03	-0.153000	2.69e-02
MASTL Facilitates Mitotic Progression	10	4.02e-01	-0.153000	5.92e-01
Neurotoxicity of clostridium toxins	10	4.04e-01	0.152000	5.93e-01
GAB1 signalosome	17	2.76e-01	-0.152000	4.61e-01
Metabolism of polyamines	55	5.05e-02	0.152000	1.53e-01
Fatty acid metabolism	167	6.76e-04	-0.152000	6.11e-03
Nervous system development	527	2.35e-09	-0.152000	1.38e-07
Aquaporin-mediated transport	51	6.18e-02	-0.151000	1.74e-01
SARS-CoV-1 Infection	51	6.21e-02	-0.151000	1.75e-01
Nicotinate metabolism	29	1.60e-01	-0.151000	3.21e-01
Amino acid transport across the plasma membrane	30	1.53e-01	-0.151000	3.11e-01
Reversible hydration of carbon dioxide	11	3.89e-01	-0.150000	5.76e-01
Class I MHC mediated antigen processing & presentation	363	8.80e-07	-0.150000	2.54e-05
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	2.58e-01	-0.150000	4.41e-01
Meiosis	56	5.25e-02	-0.150000	1.58e-01
Adrenaline,noradrenaline inhibits insulin secretion	28	1.70e-01	-0.150000	3.34e-01
Mismatch Repair	15	3.16e-01	-0.150000	4.99e-01
Golgi-to-ER retrograde transport	115	5.63e-03	-0.149000	3.36e-02
Influenza Infection	148	1.71e-03	0.149000	1.29e-02
Synthesis of PIPs at the Golgi membrane	17	2.87e-01	-0.149000	4.74e-01
G alpha (i) signalling events	306	7.53e-06	-0.149000	1.42e-04
Common Pathway of Fibrin Clot Formation	21	2.39e-01	-0.148000	4.16e-01
RHO GTPases Activate Formins	114	6.27e-03	-0.148000	3.61e-02
FGFR4 ligand binding and activation	13	3.55e-01	-0.148000	5.42e-01
N-glycan antennae elongation in the medial/trans-Golgi	26	1.94e-01	-0.147000	3.66e-01
Creation of C4 and C2 activators	14	3.40e-01	-0.147000	5.25e-01
Regulation of Complement cascade	45	8.80e-02	-0.147000	2.20e-01
TRAF6 mediated IRF7 activation	28	1.80e-01	0.146000	3.50e-01
Ubiquitin-dependent degradation of Cyclin D	50	7.34e-02	0.146000	1.94e-01
Platelet Aggregation (Plug Formation)	37	1.24e-01	-0.146000	2.72e-01
Generation of second messenger molecules	30	1.67e-01	0.146000	3.30e-01
HDACs deacetylate histones	29	1.75e-01	-0.145000	3.42e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	4.27e-01	-0.145000	6.11e-01
Synthesis, secretion, and deacylation of Ghrelin	19	2.74e-01	-0.145000	4.59e-01
RIPK1-mediated regulated necrosis	27	1.93e-01	0.145000	3.65e-01
Regulation of necroptotic cell death	27	1.93e-01	0.145000	3.65e-01
Viral Messenger RNA Synthesis	42	1.05e-01	-0.145000	2.44e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	23	2.30e-01	-0.145000	4.07e-01
ESR-mediated signaling	160	1.59e-03	-0.145000	1.22e-02
SHC1 events in EGFR signaling	14	3.50e-01	-0.144000	5.36e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	2.64e-01	0.144000	4.47e-01
Cleavage of the damaged purine	11	4.08e-01	-0.144000	5.94e-01
Depurination	11	4.08e-01	-0.144000	5.94e-01
Recognition and association of DNA glycosylase with site containing an affected purine	11	4.08e-01	-0.144000	5.94e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	4.09e-01	-0.144000	5.96e-01
Downstream signaling of activated FGFR1	31	1.67e-01	-0.143000	3.30e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	58	5.91e-02	0.143000	1.69e-01
Signaling by ERBB2	49	8.31e-02	-0.143000	2.10e-01
Anchoring of the basal body to the plasma membrane	92	1.80e-02	-0.143000	7.75e-02
Meiotic recombination	26	2.08e-01	-0.143000	3.83e-01
NRIF signals cell death from the nucleus	16	3.24e-01	0.142000	5.05e-01
Signal amplification	33	1.57e-01	-0.142000	3.17e-01
Mitotic Prometaphase	175	1.15e-03	-0.142000	9.44e-03
Negative regulation of NOTCH4 signaling	52	7.59e-02	0.142000	1.99e-01
Nuclear Receptor transcription pathway	51	7.89e-02	-0.142000	2.03e-01
Protein ubiquitination	61	5.50e-02	-0.142000	1.61e-01
RHO GTPases activate KTN1	11	4.15e-01	0.142000	6.00e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	3.12e-01	-0.142000	4.97e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	3.12e-01	-0.142000	4.97e-01
Signaling by TGF-beta Receptor Complex	86	2.33e-02	-0.141000	9.08e-02
Complement cascade	56	6.74e-02	-0.141000	1.84e-01
Retrograde transport at the Trans-Golgi-Network	47	9.39e-02	-0.141000	2.29e-01
Factors involved in megakaryocyte development and platelet production	130	5.41e-03	-0.141000	3.26e-02
Aflatoxin activation and detoxification	20	2.75e-01	0.141000	4.60e-01
Acyl chain remodelling of PS	21	2.64e-01	-0.141000	4.47e-01
Cross-presentation of soluble exogenous antigens (endosomes)	48	9.19e-02	0.141000	2.26e-01
Association of TriC/CCT with target proteins during biosynthesis	38	1.37e-01	-0.140000	2.89e-01
DNA Damage Recognition in GG-NER	36	1.48e-01	0.139000	3.03e-01
Signaling by FGFR3	39	1.32e-01	-0.139000	2.84e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	7.96e-02	0.139000	2.03e-01
Regulation of beta-cell development	41	1.23e-01	-0.139000	2.72e-01
SHC-mediated cascade:FGFR4	19	2.95e-01	-0.139000	4.82e-01
MET activates RAS signaling	11	4.26e-01	-0.139000	6.09e-01
Translation of Structural Proteins	29	1.96e-01	-0.139000	3.69e-01
Metabolism of carbohydrates	275	7.40e-05	-0.139000	9.19e-04
GRB2 events in EGFR signaling	13	3.87e-01	-0.138000	5.75e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	13	3.88e-01	-0.138000	5.75e-01
Axon guidance	503	1.06e-07	-0.138000	3.96e-06
SUMOylation of SUMOylation proteins	33	1.70e-01	-0.138000	3.34e-01
Export of Viral Ribonucleoproteins from Nucleus	31	1.86e-01	-0.137000	3.57e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	4.32e-01	-0.137000	6.15e-01
FGFR2 ligand binding and activation	19	3.04e-01	-0.136000	4.88e-01
PRC2 methylates histones and DNA	13	3.95e-01	-0.136000	5.83e-01
Norepinephrine Neurotransmitter Release Cycle	16	3.46e-01	-0.136000	5.32e-01
Glycolysis	68	5.28e-02	-0.136000	1.58e-01
AKT phosphorylates targets in the cytosol	14	3.79e-01	-0.136000	5.69e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	181	1.67e-03	-0.135000	1.27e-02
HATs acetylate histones	71	4.89e-02	-0.135000	1.50e-01
MAPK1/MAPK3 signaling	271	1.27e-04	-0.135000	1.48e-03
Mitotic Prophase	78	3.94e-02	-0.135000	1.33e-01
Signaling by ERBB2 in Cancer	25	2.44e-01	-0.135000	4.20e-01
RAF/MAP kinase cascade	265	1.64e-04	-0.134000	1.83e-03
Sema4D in semaphorin signaling	24	2.55e-01	-0.134000	4.37e-01
COPI-dependent Golgi-to-ER retrograde traffic	81	3.77e-02	-0.134000	1.29e-01
Pre-NOTCH Expression and Processing	61	7.14e-02	-0.133000	1.90e-01
Signaling by Retinoic Acid	41	1.40e-01	-0.133000	2.94e-01
Signaling by WNT	263	1.99e-04	-0.133000	2.12e-03
Mitotic Spindle Checkpoint	106	1.79e-02	-0.133000	7.75e-02
Hedgehog ligand biogenesis	63	6.78e-02	0.133000	1.84e-01
Intracellular signaling by second messengers	313	5.30e-05	-0.133000	6.93e-04
Signaling by TGFB family members	114	1.45e-02	-0.132000	6.72e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	1.83e-01	-0.132000	3.52e-01
Signaling by ERBB2 TMD/JMD mutants	21	2.95e-01	-0.132000	4.82e-01
Metabolism of folate and pterines	16	3.62e-01	-0.132000	5.49e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	3.94e-01	0.132000	5.82e-01
ADORA2B mediated anti-inflammatory cytokines production	132	9.12e-03	-0.131000	4.76e-02
NGF-stimulated transcription	39	1.56e-01	0.131000	3.16e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	1.09e-01	0.131000	2.49e-01
p53-Independent DNA Damage Response	50	1.09e-01	0.131000	2.49e-01
p53-Independent G1/S DNA damage checkpoint	50	1.09e-01	0.131000	2.49e-01
Nuclear import of Rev protein	32	2.00e-01	-0.131000	3.74e-01
G-protein beta:gamma signalling	30	2.15e-01	-0.131000	3.89e-01
Regulation of APC/C activators between G1/S and early anaphase	79	4.45e-02	0.131000	1.44e-01
SUMOylation of RNA binding proteins	45	1.30e-01	-0.130000	2.80e-01
Meiotic synapsis	32	2.02e-01	-0.130000	3.76e-01
Hyaluronan metabolism	17	3.52e-01	-0.130000	5.40e-01
p53-Dependent G1 DNA Damage Response	64	7.15e-02	0.130000	1.90e-01
p53-Dependent G1/S DNA damage checkpoint	64	7.15e-02	0.130000	1.90e-01
Termination of O-glycan biosynthesis	25	2.60e-01	-0.130000	4.41e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	3.99e-01	0.130000	5.88e-01
Reproduction	82	4.24e-02	-0.130000	1.40e-01
Regulation of RUNX3 expression and activity	53	1.05e-01	0.129000	2.44e-01
Transcriptional regulation of white adipocyte differentiation	81	4.52e-02	-0.129000	1.45e-01
FRS-mediated FGFR1 signaling	23	2.86e-01	-0.129000	4.73e-01
CS/DS degradation	12	4.40e-01	-0.129000	6.22e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	22	2.97e-01	-0.128000	4.83e-01
Neurodegenerative Diseases	22	2.97e-01	-0.128000	4.83e-01
PI-3K cascade:FGFR1	21	3.09e-01	-0.128000	4.95e-01
Leishmania infection	245	5.39e-04	-0.128000	5.22e-03
RHO GTPase Effectors	232	7.96e-04	-0.128000	7.03e-03
Estrogen-dependent gene expression	91	3.53e-02	-0.128000	1.24e-01
Transcriptional activation of mitochondrial biogenesis	51	1.16e-01	-0.127000	2.60e-01
Prostacyclin signalling through prostacyclin receptor	19	3.37e-01	-0.127000	5.22e-01
BBSome-mediated cargo-targeting to cilium	23	2.94e-01	-0.126000	4.82e-01
Degradation of AXIN	53	1.11e-01	0.126000	2.54e-01
APC/C-mediated degradation of cell cycle proteins	86	4.28e-02	0.126000	1.40e-01
Regulation of mitotic cell cycle	86	4.28e-02	0.126000	1.40e-01
Interferon gamma signaling	90	3.85e-02	-0.126000	1.31e-01
Centrosome maturation	77	5.57e-02	-0.126000	1.62e-01
Recruitment of mitotic centrosome proteins and complexes	77	5.57e-02	-0.126000	1.62e-01
Folding of actin by CCT/TriC	10	4.90e-01	-0.126000	6.63e-01
Post-translational protein modification	1294	1.94e-14	-0.126000	2.96e-12
Mitochondrial translation initiation	87	4.25e-02	0.126000	1.40e-01
Signaling by ERBB4	57	1.00e-01	-0.126000	2.37e-01
Phosphorylation of the APC/C	20	3.30e-01	0.126000	5.14e-01
Butyrophilin (BTN) family interactions	12	4.51e-01	0.126000	6.30e-01
Regulation of actin dynamics for phagocytic cup formation	59	9.70e-02	-0.125000	2.33e-01
SCF-beta-TrCP mediated degradation of Emi1	53	1.16e-01	0.125000	2.61e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	4.95e-01	-0.125000	6.64e-01
mRNA Splicing - Minor Pathway	53	1.17e-01	0.125000	2.62e-01
Potential therapeutics for SARS	83	4.98e-02	-0.125000	1.52e-01
Glucose metabolism	87	4.47e-02	-0.124000	1.44e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	1.96e-01	0.124000	3.70e-01
DAP12 signaling	28	2.55e-01	-0.124000	4.37e-01
Membrane binding and targetting of GAG proteins	14	4.22e-01	0.124000	6.06e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	4.22e-01	0.124000	6.06e-01
Signaling by FGFR4	40	1.75e-01	-0.124000	3.41e-01
Erythropoietin activates RAS	14	4.24e-01	-0.123000	6.08e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	87	4.81e-02	0.123000	1.49e-01
Anti-inflammatory response favouring Leishmania parasite infection	164	6.92e-03	-0.122000	3.84e-02
Leishmania parasite growth and survival	164	6.92e-03	-0.122000	3.84e-02
RHOBTB GTPase Cycle	34	2.18e-01	-0.122000	3.92e-01
Cytochrome c-mediated apoptotic response	12	4.64e-01	0.122000	6.39e-01
RHO GTPases activate CIT	19	3.58e-01	-0.122000	5.45e-01
SUMO E3 ligases SUMOylate target proteins	158	8.19e-03	-0.122000	4.33e-02
Initial triggering of complement	21	3.35e-01	-0.122000	5.18e-01
Formation of Incision Complex in GG-NER	40	1.84e-01	-0.121000	3.54e-01
Suppression of phagosomal maturation	13	4.50e-01	-0.121000	6.29e-01
Golgi Associated Vesicle Biogenesis	51	1.35e-01	-0.121000	2.87e-01
ADP signalling through P2Y purinoceptor 1	25	2.95e-01	-0.121000	4.82e-01
Glycogen synthesis	15	4.18e-01	-0.121000	6.02e-01
Signaling by Insulin receptor	76	7.07e-02	-0.120000	1.89e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	16	4.06e-01	-0.120000	5.94e-01
Phase 4 - resting membrane potential	19	3.66e-01	-0.120000	5.54e-01
MAPK family signaling cascades	312	2.71e-04	-0.120000	2.84e-03
RHOBTB2 GTPase cycle	22	3.32e-01	-0.119000	5.15e-01
Metabolic disorders of biological oxidation enzymes	32	2.42e-01	-0.119000	4.19e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	52	1.36e-01	-0.119000	2.89e-01
Disorders of transmembrane transporters	167	7.83e-03	-0.119000	4.21e-02
Constitutive Signaling by Overexpressed ERBB2	10	5.14e-01	0.119000	6.80e-01
trans-Golgi Network Vesicle Budding	67	9.25e-02	-0.119000	2.27e-01
Recruitment of NuMA to mitotic centrosomes	76	7.46e-02	-0.118000	1.96e-01
Interleukin-6 family signaling	24	3.16e-01	-0.118000	4.99e-01
Stabilization of p53	55	1.31e-01	0.118000	2.81e-01
PI3K events in ERBB4 signaling	10	5.19e-01	-0.118000	6.82e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	34	2.35e-01	-0.118000	4.13e-01
Josephin domain DUBs	11	5.00e-01	0.117000	6.67e-01
Transport to the Golgi and subsequent modification	165	9.39e-03	-0.117000	4.88e-02
Detoxification of Reactive Oxygen Species	35	2.31e-01	-0.117000	4.08e-01
Developmental Biology	1020	2.26e-10	-0.117000	1.73e-08
Glutathione conjugation	37	2.19e-01	0.117000	3.92e-01
Gap junction trafficking and regulation	29	2.76e-01	-0.117000	4.61e-01
DNA Double-Strand Break Repair	130	2.18e-02	-0.116000	8.91e-02
Metabolism of water-soluble vitamins and cofactors	118	2.92e-02	-0.116000	1.09e-01
Metabolism	1967	9.90e-18	-0.116000	2.16e-15
Clathrin-mediated endocytosis	135	2.01e-02	-0.116000	8.47e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21	3.60e-01	0.115000	5.47e-01
Regulation of Apoptosis	51	1.55e-01	0.115000	3.15e-01
Transcription of E2F targets under negative control by DREAM complex	19	3.86e-01	-0.115000	5.75e-01
ER to Golgi Anterograde Transport	134	2.15e-02	-0.115000	8.82e-02
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	1.60e-01	0.115000	3.21e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	5.29e-01	-0.115000	6.86e-01
TBC/RABGAPs	42	1.98e-01	-0.115000	3.72e-01
Cyclin A/B1/B2 associated events during G2/M transition	24	3.32e-01	-0.114000	5.15e-01
Peptide hormone biosynthesis	11	5.12e-01	-0.114000	6.77e-01
G1/S DNA Damage Checkpoints	66	1.09e-01	0.114000	2.50e-01
Translation	263	1.46e-03	0.114000	1.15e-02
Signaling by FGFR2	72	9.51e-02	-0.114000	2.31e-01
Assembly Of The HIV Virion	16	4.32e-01	0.113000	6.15e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	4.63e-01	-0.113000	6.39e-01
RUNX2 regulates osteoblast differentiation	22	3.58e-01	-0.113000	5.45e-01
Mitochondrial translation termination	87	6.81e-02	0.113000	1.84e-01
Regulation of innate immune responses to cytosolic DNA	14	4.64e-01	0.113000	6.39e-01
TICAM1-dependent activation of IRF3/IRF7	12	4.99e-01	0.113000	6.66e-01
Transport of Mature Transcript to Cytoplasm	76	8.92e-02	-0.113000	2.22e-01
SUMOylation	164	1.27e-02	-0.113000	6.05e-02
Mitochondrial translation elongation	87	6.98e-02	0.112000	1.88e-01
Signaling by Hedgehog	133	2.54e-02	-0.112000	9.75e-02
Asymmetric localization of PCP proteins	62	1.28e-01	0.112000	2.78e-01
Degradation of GLI2 by the proteasome	58	1.41e-01	0.112000	2.94e-01
GLI3 is processed to GLI3R by the proteasome	58	1.41e-01	0.112000	2.95e-01
activated TAK1 mediates p38 MAPK activation	16	4.40e-01	0.112000	6.21e-01
COPII-mediated vesicle transport	66	1.17e-01	-0.111000	2.62e-01
Defective CFTR causes cystic fibrosis	59	1.39e-01	0.111000	2.92e-01
Deactivation of the beta-catenin transactivating complex	39	2.29e-01	-0.111000	4.07e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	3.10e-01	-0.111000	4.97e-01
Glycosphingolipid metabolism	40	2.28e-01	-0.110000	4.06e-01
Caspase activation via Death Receptors in the presence of ligand	16	4.45e-01	0.110000	6.26e-01
Degradation of DVL	55	1.58e-01	0.110000	3.19e-01
Glucagon-type ligand receptors	33	2.76e-01	-0.110000	4.61e-01
Ovarian tumor domain proteases	36	2.56e-01	-0.109000	4.37e-01
mRNA Capping	28	3.16e-01	-0.109000	4.99e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	4.95e-01	-0.109000	6.64e-01
HCMV Infection	79	9.30e-02	-0.109000	2.28e-01
TCF dependent signaling in response to WNT	168	1.47e-02	-0.109000	6.76e-02
Loss of Nlp from mitotic centrosomes	65	1.28e-01	-0.109000	2.79e-01
Loss of proteins required for interphase microtubule organization from the centrosome	65	1.28e-01	-0.109000	2.79e-01
Dectin-1 mediated noncanonical NF-kB signaling	60	1.45e-01	0.109000	3.00e-01
Regulated proteolysis of p75NTR	11	5.33e-01	0.108000	6.88e-01
SUMOylation of DNA replication proteins	44	2.13e-01	-0.108000	3.87e-01
Disease	1624	2.53e-13	-0.108000	2.94e-11
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	3.22e-01	-0.108000	5.04e-01
SHC1 events in ERBB4 signaling	14	4.85e-01	-0.108000	6.60e-01
Acyl chain remodelling of PG	18	4.29e-01	-0.108000	6.13e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	4.05e-01	-0.108000	5.93e-01
Switching of origins to a post-replicative state	90	7.78e-02	0.107000	2.02e-01
SUMOylation of DNA methylation proteins	16	4.57e-01	-0.107000	6.36e-01
Peptide hormone metabolism	83	9.09e-02	-0.107000	2.24e-01
Peroxisomal protein import	62	1.44e-01	-0.107000	2.99e-01
IRAK4 deficiency (TLR2/4)	17	4.47e-01	0.107000	6.27e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	4.75e-01	0.107000	6.50e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	4.91e-01	-0.106000	6.63e-01
ISG15 antiviral mechanism	71	1.22e-01	-0.106000	2.70e-01
Gastrin-CREB signalling pathway via PKC and MAPK	17	4.49e-01	-0.106000	6.29e-01
Senescence-Associated Secretory Phenotype (SASP)	53	1.82e-01	0.106000	3.51e-01
Defective pyroptosis	11	5.46e-01	-0.105000	6.99e-01
Intrinsic Pathway for Apoptosis	52	1.90e-01	-0.105000	3.62e-01
Signaling by NTRKs	133	3.62e-02	-0.105000	1.26e-01
NIK–>noncanonical NF-kB signaling	57	1.70e-01	0.105000	3.34e-01
Mitochondrial translation	93	8.01e-02	0.105000	2.04e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	95	7.74e-02	0.105000	2.01e-01
Plasma lipoprotein assembly	19	4.32e-01	-0.104000	6.15e-01
Acyl chain remodelling of PE	24	3.78e-01	-0.104000	5.67e-01
PIWI-interacting RNA (piRNA) biogenesis	29	3.35e-01	-0.103000	5.18e-01
FGFR1c ligand binding and activation	11	5.55e-01	-0.103000	7.07e-01
Signaling by activated point mutants of FGFR1	11	5.55e-01	-0.103000	7.07e-01
Signaling by NOTCH	183	1.64e-02	-0.103000	7.19e-02
Amine ligand-binding receptors	41	2.55e-01	-0.103000	4.37e-01
N-Glycan antennae elongation	15	4.91e-01	-0.103000	6.63e-01
Prolactin receptor signaling	15	4.92e-01	-0.102000	6.64e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	4.78e-01	-0.102000	6.53e-01
Hedgehog ‘off’ state	97	8.15e-02	-0.102000	2.07e-01
MHC class II antigen presentation	104	7.21e-02	-0.102000	1.91e-01
Signaling by NOTCH2	32	3.18e-01	-0.102000	5.00e-01
RHO GTPases Activate ROCKs	19	4.43e-01	-0.102000	6.24e-01
Digestion and absorption	26	3.70e-01	-0.102000	5.58e-01
MAP kinase activation	58	1.81e-01	-0.101000	3.50e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	3.63e-01	-0.101000	5.50e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	11	5.64e-01	0.101000	7.16e-01
Sema4D induced cell migration and growth-cone collapse	20	4.36e-01	-0.100000	6.19e-01
Deadenylation-dependent mRNA decay	56	1.93e-01	-0.100000	3.66e-01
Growth hormone receptor signaling	24	3.94e-01	-0.100000	5.82e-01
Transcriptional regulation by small RNAs	46	2.39e-01	-0.100000	4.16e-01
Antiviral mechanism by IFN-stimulated genes	78	1.25e-01	-0.100000	2.75e-01
Depolymerisation of the Nuclear Lamina	14	5.16e-01	-0.100000	6.80e-01
Synthesis of substrates in N-glycan biosythesis	60	1.80e-01	-0.100000	3.50e-01
Negative regulators of DDX58/IFIH1 signaling	34	3.14e-01	-0.099800	4.99e-01
Cholesterol biosynthesis	24	4.00e-01	-0.099300	5.88e-01
Activation of NF-kappaB in B cells	64	1.70e-01	0.099100	3.34e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	4.93e-01	0.099000	6.64e-01
RHOBTB1 GTPase cycle	22	4.21e-01	-0.099000	6.06e-01
Carboxyterminal post-translational modifications of tubulin	40	2.79e-01	-0.098900	4.64e-01
Glycogen breakdown (glycogenolysis)	12	5.53e-01	0.098900	7.07e-01
ADP signalling through P2Y purinoceptor 12	22	4.22e-01	-0.098800	6.06e-01
Assembly of the pre-replicative complex	82	1.23e-01	0.098300	2.72e-01
Transport of vitamins, nucleosides, and related molecules	38	2.95e-01	-0.098200	4.82e-01
FGFR2 alternative splicing	26	3.86e-01	-0.098100	5.75e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	3.69e-01	-0.098100	5.57e-01
Cytosolic sulfonation of small molecules	23	4.16e-01	-0.098000	6.01e-01
Cargo recognition for clathrin-mediated endocytosis	98	9.41e-02	-0.097800	2.29e-01
Ethanol oxidation	12	5.58e-01	0.097700	7.11e-01
Interleukin-7 signaling	21	4.38e-01	-0.097700	6.20e-01
Acetylcholine Neurotransmitter Release Cycle	16	4.99e-01	-0.097700	6.66e-01
Asparagine N-linked glycosylation	278	5.07e-03	-0.097500	3.11e-02
ER-Phagosome pathway	87	1.17e-01	0.097200	2.62e-01
Activation of kainate receptors upon glutamate binding	29	3.67e-01	-0.096800	5.55e-01
Gluconeogenesis	32	3.44e-01	-0.096700	5.29e-01
Signaling by FGFR	85	1.23e-01	-0.096700	2.72e-01
Respiratory electron transport	90	1.13e-01	0.096700	2.56e-01
Gap junction trafficking	27	3.86e-01	-0.096400	5.75e-01
Activation of the AP-1 family of transcription factors	10	5.98e-01	0.096300	7.44e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	5.67e-01	-0.095500	7.17e-01
COPI-mediated anterograde transport	83	1.33e-01	-0.095300	2.85e-01
Negative regulation of FLT3	15	5.25e-01	0.094700	6.86e-01
Diseases associated with N-glycosylation of proteins	19	4.76e-01	-0.094500	6.50e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	1.60e-01	-0.094400	3.22e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	32	3.58e-01	0.093800	5.45e-01
EGFR downregulation	30	3.74e-01	-0.093800	5.63e-01
PIP3 activates AKT signaling	275	7.55e-03	-0.093500	4.09e-02
Regulation of gene expression in beta cells	21	4.60e-01	-0.093200	6.39e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	4.95e-01	-0.092900	6.64e-01
FLT3 Signaling	38	3.21e-01	-0.092900	5.04e-01
Macroautophagy	111	9.10e-02	-0.092800	2.24e-01
IRF3-mediated induction of type I IFN	11	5.98e-01	-0.091800	7.44e-01
Translesion Synthesis by POLH	19	4.89e-01	0.091600	6.63e-01
TNFR2 non-canonical NF-kB pathway	94	1.27e-01	0.091100	2.77e-01
RUNX3 regulates p14-ARF	10	6.18e-01	-0.091000	7.59e-01
Synthesis of DNA	118	8.77e-02	0.091000	2.20e-01
Metabolism of amine-derived hormones	17	5.17e-01	-0.090700	6.80e-01
Sulfur amino acid metabolism	27	4.15e-01	-0.090600	6.00e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	4.33e-01	-0.090600	6.15e-01
Passive transport by Aquaporins	13	5.72e-01	0.090500	7.21e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	6.03e-01	-0.090500	7.47e-01
TGF-beta receptor signaling activates SMADs	45	2.94e-01	-0.090300	4.82e-01
Processive synthesis on the C-strand of the telomere	19	4.95e-01	-0.090300	6.64e-01
Digestion	21	4.76e-01	-0.089800	6.50e-01
Metabolism of proteins	1774	2.78e-10	-0.089600	2.02e-08
MAPK6/MAPK4 signaling	89	1.45e-01	0.089300	3.00e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	5.24e-01	0.089200	6.86e-01
Orc1 removal from chromatin	69	2.01e-01	0.088900	3.75e-01
mTORC1-mediated signalling	23	4.61e-01	-0.088900	6.39e-01
Cellular response to heat stress	95	1.36e-01	-0.088500	2.88e-01
Uptake and actions of bacterial toxins	29	4.10e-01	-0.088300	5.96e-01
Condensation of Prophase Chromosomes	12	5.96e-01	-0.088300	7.43e-01
MyD88 deficiency (TLR2/4)	16	5.43e-01	0.087900	6.98e-01
Regulation of PLK1 Activity at G2/M Transition	83	1.66e-01	-0.087800	3.30e-01
Cytosolic iron-sulfur cluster assembly	10	6.31e-01	-0.087700	7.70e-01
Cyclin D associated events in G1	46	3.04e-01	-0.087600	4.88e-01
G1 Phase	46	3.04e-01	-0.087600	4.88e-01
Regulation of TP53 Activity through Acetylation	29	4.14e-01	-0.087600	6.00e-01
Transport of bile salts and organic acids, metal ions and amine compounds	84	1.67e-01	-0.087200	3.30e-01
Class I peroxisomal membrane protein import	19	5.11e-01	0.087200	6.77e-01
Dual Incision in GG-NER	39	3.47e-01	-0.087100	5.33e-01
Other interleukin signaling	24	4.63e-01	0.086500	6.39e-01
Basigin interactions	24	4.65e-01	-0.086200	6.39e-01
Purine catabolism	17	5.39e-01	-0.086000	6.94e-01
Thromboxane signalling through TP receptor	24	4.67e-01	-0.085800	6.41e-01
Fertilization	26	4.50e-01	-0.085700	6.29e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	5.41e-01	0.085500	6.96e-01
Oxidative Stress Induced Senescence	66	2.30e-01	-0.085500	4.07e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	6.09e-01	-0.085400	7.50e-01
Pre-NOTCH Processing in Golgi	18	5.31e-01	-0.085200	6.87e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	5.82e-01	-0.085100	7.31e-01
RHO GTPases Activate WASPs and WAVEs	34	3.92e-01	-0.084900	5.79e-01
Neurotransmitter release cycle	47	3.18e-01	-0.084200	5.00e-01
ERKs are inactivated	13	6.01e-01	0.083700	7.47e-01
Purine ribonucleoside monophosphate biosynthesis	11	6.31e-01	-0.083700	7.70e-01
Diseases of DNA repair	49	3.11e-01	-0.083600	4.97e-01
Antigen processing-Cross presentation	102	1.46e-01	0.083200	3.01e-01
Acyl chain remodelling of PI	16	5.66e-01	-0.082900	7.17e-01
Protein folding	96	1.62e-01	-0.082500	3.23e-01
Signaling by FGFR1	49	3.20e-01	-0.082200	5.01e-01
Degradation of GLI1 by the proteasome	58	2.80e-01	0.082100	4.64e-01
Activation of ATR in response to replication stress	37	3.89e-01	-0.081800	5.76e-01
Epigenetic regulation of gene expression	83	1.98e-01	-0.081700	3.72e-01
MicroRNA (miRNA) biogenesis	26	4.73e-01	-0.081300	6.48e-01
Frs2-mediated activation	12	6.26e-01	-0.081300	7.67e-01
DNA Repair	277	2.01e-02	-0.081100	8.47e-02
ERK/MAPK targets	20	5.30e-01	-0.081000	6.87e-01
G2/M DNA damage checkpoint	58	2.86e-01	-0.081000	4.73e-01
Cell surface interactions at the vascular wall	129	1.12e-01	-0.081000	2.55e-01
HSF1-dependent transactivation	35	4.07e-01	-0.081000	5.94e-01
Adaptive Immune System	711	2.27e-04	-0.080900	2.41e-03
Postmitotic nuclear pore complex (NPC) reformation	26	4.76e-01	-0.080800	6.50e-01
Pyruvate metabolism	29	4.52e-01	-0.080800	6.30e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	4.95e-01	-0.080500	6.64e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	6.44e-01	-0.080500	7.78e-01
Transcriptional regulation by RUNX2	116	1.34e-01	-0.080400	2.87e-01
Plasma lipoprotein remodeling	32	4.31e-01	-0.080300	6.15e-01
Xenobiotics	24	4.97e-01	-0.080000	6.65e-01
Negative regulation of FGFR2 signaling	33	4.29e-01	-0.079500	6.13e-01
DNA Replication	125	1.26e-01	0.079300	2.76e-01
Transcriptional Regulation by E2F6	32	4.38e-01	-0.079200	6.20e-01
Autophagy	125	1.26e-01	-0.079100	2.76e-01
Interleukin-17 signaling	66	2.67e-01	-0.079000	4.49e-01
HDR through Single Strand Annealing (SSA)	36	4.12e-01	-0.078900	5.99e-01
Regulation of TP53 Activity through Phosphorylation	88	2.01e-01	0.078800	3.75e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	67	2.65e-01	-0.078700	4.47e-01
IKK complex recruitment mediated by RIP1	22	5.23e-01	-0.078600	6.86e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	94	1.90e-01	-0.078100	3.62e-01
SUMOylation of transcription cofactors	43	3.76e-01	-0.078100	5.65e-01
Cell Cycle	602	1.07e-03	-0.077800	8.91e-03
Toll Like Receptor 4 (TLR4) Cascade	124	1.35e-01	-0.077700	2.87e-01
Pausing and recovery of Tat-mediated HIV elongation	27	4.86e-01	0.077500	6.61e-01
Tat-mediated HIV elongation arrest and recovery	27	4.86e-01	0.077500	6.61e-01
Miscellaneous substrates	12	6.43e-01	0.077200	7.78e-01
Cell recruitment (pro-inflammatory response)	25	5.04e-01	-0.077200	6.71e-01
Purinergic signaling in leishmaniasis infection	25	5.04e-01	-0.077200	6.71e-01
Expression and translocation of olfactory receptors	365	1.13e-02	0.077100	5.53e-02
Metabolism of RNA	638	8.87e-04	0.076900	7.57e-03
MAPK targets/ Nuclear events mediated by MAP kinases	29	4.76e-01	-0.076500	6.50e-01
Glutamate Neurotransmitter Release Cycle	23	5.25e-01	-0.076500	6.86e-01
AURKA Activation by TPX2	68	2.77e-01	-0.076200	4.62e-01
Fc epsilon receptor (FCERI) signaling	126	1.40e-01	-0.076100	2.94e-01
MyD88-independent TLR4 cascade	92	2.09e-01	-0.075800	3.83e-01
TRIF(TICAM1)-mediated TLR4 signaling	92	2.09e-01	-0.075800	3.83e-01
Neddylation	228	5.00e-02	-0.075300	1.53e-01
G1/S-Specific Transcription	28	4.93e-01	-0.074800	6.64e-01
Killing mechanisms	11	6.68e-01	0.074700	7.99e-01
WNT5:FZD7-mediated leishmania damping	11	6.68e-01	0.074700	7.99e-01
Pyroptosis	26	5.10e-01	-0.074600	6.77e-01
DNA Replication Pre-Initiation	97	2.05e-01	0.074400	3.82e-01
HDL remodeling	10	6.84e-01	-0.074400	8.08e-01
Pregnenolone biosynthesis	10	6.87e-01	-0.073600	8.09e-01
Amyloid fiber formation	53	3.55e-01	-0.073500	5.42e-01
Costimulation by the CD28 family	65	3.06e-01	-0.073400	4.91e-01
Negative regulation of FGFR3 signaling	28	5.02e-01	-0.073300	6.69e-01
Downstream TCR signaling	92	2.24e-01	0.073300	4.00e-01
Metabolism of nucleotides	95	2.17e-01	-0.073200	3.92e-01
RHO GTPases activate PKNs	34	4.61e-01	-0.073000	6.39e-01
RNA Polymerase I Transcription Initiation	42	4.14e-01	-0.072900	6.00e-01
HCMV Late Events	54	3.54e-01	-0.072800	5.42e-01
ABC-family proteins mediated transport	98	2.14e-01	-0.072600	3.88e-01
RNA Pol II CTD phosphorylation and interaction with CE	26	5.22e-01	-0.072500	6.85e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	5.22e-01	-0.072500	6.85e-01
Interferon alpha/beta signaling	71	2.91e-01	0.072400	4.79e-01
Nuclear Events (kinase and transcription factor activation)	60	3.32e-01	0.072400	5.15e-01
Defective Intrinsic Pathway for Apoptosis	25	5.31e-01	-0.072400	6.87e-01
Glutathione synthesis and recycling	13	6.52e-01	-0.072200	7.85e-01
Signaling by ROBO receptors	203	7.68e-02	0.072000	2.00e-01
Formation of the cornified envelope	74	2.84e-01	-0.071900	4.72e-01
Transcriptional regulation by RUNX1	183	9.59e-02	-0.071300	2.32e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	5.92e-01	-0.071000	7.40e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	5.92e-01	-0.071000	7.40e-01
Regulation of TP53 Activity through Methylation	18	6.02e-01	-0.071000	7.47e-01
Signaling by NTRK1 (TRKA)	114	1.90e-01	-0.071000	3.62e-01
mRNA Splicing	183	9.91e-02	0.070600	2.36e-01
TRAF3-dependent IRF activation pathway	15	6.37e-01	-0.070300	7.76e-01
Prefoldin mediated transfer of substrate to CCT/TriC	27	5.28e-01	0.070200	6.86e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	16	6.30e-01	0.069500	7.70e-01
GPCR ligand binding	444	1.20e-02	-0.069400	5.77e-02
Tryptophan catabolism	12	6.79e-01	-0.069100	8.05e-01
Activation of the pre-replicative complex	31	5.07e-01	-0.068800	6.75e-01
mRNA Editing	10	7.08e-01	-0.068300	8.21e-01
Olfactory Signaling Pathway	372	2.35e-02	0.068300	9.10e-02
Resolution of D-loop Structures through Holliday Junction Intermediates	31	5.12e-01	-0.068000	6.77e-01
Endosomal/Vacuolar pathway	12	6.85e-01	-0.067700	8.08e-01
Recognition of DNA damage by PCNA-containing replication complex	29	5.29e-01	-0.067500	6.86e-01
Downregulation of TGF-beta receptor signaling	26	5.51e-01	0.067500	7.06e-01
Regulation of HSF1-mediated heat shock response	78	3.04e-01	-0.067300	4.88e-01
M Phase	336	3.38e-02	-0.067300	1.19e-01
Beta-catenin independent WNT signaling	144	1.63e-01	-0.067300	3.25e-01
FOXO-mediated transcription of cell cycle genes	16	6.42e-01	-0.067200	7.78e-01
Removal of the Flap Intermediate from the C-strand	17	6.33e-01	-0.066900	7.70e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	6.66e-01	0.066600	7.98e-01
Cell Cycle, Mitotic	477	1.27e-02	-0.066500	6.05e-02
Nuclear events mediated by NFE2L2	76	3.16e-01	0.066400	4.99e-01
Plasma lipoprotein assembly, remodeling, and clearance	73	3.26e-01	-0.066400	5.09e-01
Regulation of gene expression by Hypoxia-inducible Factor	11	7.05e-01	-0.065800	8.21e-01
Spry regulation of FGF signaling	16	6.49e-01	0.065800	7.83e-01
Homology Directed Repair	100	2.59e-01	-0.065300	4.41e-01
Mitochondrial iron-sulfur cluster biogenesis	12	6.96e-01	0.065200	8.14e-01
Phase II - Conjugation of compounds	109	2.39e-01	-0.065200	4.16e-01
Toll Like Receptor 3 (TLR3) Cascade	88	2.92e-01	-0.064900	4.80e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	4.32e-01	-0.064800	6.15e-01
Telomere C-strand (Lagging Strand) Synthesis	32	5.29e-01	-0.064300	6.86e-01
Programmed Cell Death	192	1.26e-01	-0.064000	2.76e-01
tRNA modification in the nucleus and cytosol	38	4.96e-01	-0.063800	6.65e-01
Resolution of D-Loop Structures	32	5.33e-01	-0.063700	6.88e-01
Apoptosis	164	1.61e-01	-0.063400	3.22e-01
Interleukin-12 signaling	44	4.67e-01	0.063400	6.41e-01
RAF-independent MAPK1/3 activation	22	6.07e-01	-0.063400	7.50e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	5.70e-01	-0.063200	7.20e-01
Regulation of TP53 Degradation	36	5.12e-01	-0.063200	6.77e-01
Processing of SMDT1	15	6.74e-01	-0.062800	8.03e-01
Infection with Mycobacterium tuberculosis	26	5.81e-01	-0.062600	7.30e-01
Striated Muscle Contraction	33	5.37e-01	-0.062100	6.92e-01
RA biosynthesis pathway	22	6.16e-01	-0.061800	7.57e-01
ROS and RNS production in phagocytes	35	5.27e-01	0.061800	6.86e-01
FLT3 signaling in disease	28	5.72e-01	-0.061700	7.21e-01
Polymerase switching on the C-strand of the telomere	24	6.02e-01	-0.061500	7.47e-01
Chaperonin-mediated protein folding	90	3.16e-01	-0.061100	4.99e-01
HIV elongation arrest and recovery	29	5.72e-01	0.060600	7.21e-01
Pausing and recovery of HIV elongation	29	5.72e-01	0.060600	7.21e-01
Metabolism of Angiotensinogen to Angiotensins	15	6.85e-01	0.060400	8.09e-01
Metabolism of non-coding RNA	50	4.62e-01	-0.060100	6.39e-01
snRNP Assembly	50	4.62e-01	-0.060100	6.39e-01
Interleukin-10 signaling	45	4.88e-01	0.059700	6.63e-01
Homologous DNA Pairing and Strand Exchange	41	5.10e-01	-0.059500	6.77e-01
Presynaptic phase of homologous DNA pairing and strand exchange	38	5.26e-01	-0.059500	6.86e-01
Signaling by Activin	15	6.90e-01	0.059400	8.10e-01
Rap1 signalling	16	6.82e-01	-0.059200	8.07e-01
CD28 dependent Vav1 pathway	11	7.34e-01	-0.059200	8.41e-01
FCERI mediated NF-kB activation	74	3.81e-01	0.058900	5.70e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	6.93e-01	0.058800	8.13e-01
G beta:gamma signalling through BTK	17	6.76e-01	-0.058500	8.03e-01
RAS processing	19	6.59e-01	-0.058500	7.92e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	21	6.44e-01	0.058300	7.78e-01
Formation of RNA Pol II elongation complex	53	4.63e-01	-0.058300	6.39e-01
RNA Polymerase II Transcription Elongation	53	4.63e-01	-0.058300	6.39e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	5.69e-01	-0.058200	7.19e-01
STING mediated induction of host immune responses	13	7.18e-01	-0.057900	8.29e-01
Response of Mtb to phagocytosis	22	6.38e-01	-0.057900	7.76e-01
Initiation of Nuclear Envelope (NE) Reformation	18	6.72e-01	-0.057700	8.02e-01
Regulation of RAS by GAPs	66	4.21e-01	0.057300	6.06e-01
Cellular response to hypoxia	71	4.04e-01	0.057200	5.93e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	68	4.16e-01	0.057000	6.01e-01
Negative regulation of FGFR4 signaling	30	5.90e-01	-0.056800	7.38e-01
Gene expression (Transcription)	1407	3.33e-04	-0.056800	3.41e-03
TP53 Regulates Transcription of Death Receptors and Ligands	12	7.35e-01	-0.056300	8.42e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	62	4.43e-01	0.056300	6.24e-01
Toll-like Receptor Cascades	143	2.45e-01	-0.056200	4.23e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	6.29e-01	0.055900	7.68e-01
Biosynthesis of DHA-derived SPMs	17	6.90e-01	0.055800	8.10e-01
Diseases of programmed cell death	41	5.37e-01	-0.055700	6.92e-01
Cellular Senescence	130	2.72e-01	-0.055700	4.57e-01
SARS-CoV Infections	339	7.80e-02	-0.055600	2.02e-01
Unwinding of DNA	12	7.39e-01	0.055600	8.44e-01
Na+/Cl- dependent neurotransmitter transporters	18	6.84e-01	-0.055400	8.08e-01
Impaired BRCA2 binding to RAD51	33	5.82e-01	-0.055300	7.31e-01
Cell Cycle Checkpoints	248	1.34e-01	-0.055300	2.85e-01
Chromosome Maintenance	86	3.76e-01	-0.055200	5.65e-01
Chylomicron assembly	10	7.63e-01	-0.055100	8.60e-01
Diseases associated with glycosylation precursor biosynthesis	15	7.12e-01	-0.055000	8.24e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	6.71e-01	0.054800	8.02e-01
TCR signaling	112	3.17e-01	0.054700	4.99e-01
Class A/1 (Rhodopsin-like receptors)	312	9.99e-02	-0.054100	2.37e-01
RNA Polymerase I Transcription Termination	27	6.27e-01	0.054100	7.67e-01
Translesion synthesis by REV1	16	7.09e-01	-0.053800	8.22e-01
Immune System	1877	1.10e-04	-0.053500	1.30e-03
Cyclin E associated events during G1/S transition	81	4.07e-01	0.053300	5.94e-01
Mitochondrial calcium ion transport	22	6.65e-01	-0.053300	7.98e-01
Infectious disease	885	7.01e-03	-0.053200	3.87e-02
Activation of Matrix Metalloproteinases	31	6.09e-01	-0.053000	7.50e-01
Advanced glycosylation endproduct receptor signaling	13	7.41e-01	0.052900	8.46e-01
Protein methylation	16	7.17e-01	0.052400	8.28e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	112	3.39e-01	-0.052300	5.23e-01
Lysosome Vesicle Biogenesis	33	6.03e-01	-0.052200	7.47e-01
Formation of the Early Elongation Complex	32	6.09e-01	-0.052200	7.50e-01
Formation of the HIV-1 Early Elongation Complex	32	6.09e-01	-0.052200	7.50e-01
G0 and Early G1	27	6.39e-01	-0.052100	7.76e-01
Dual incision in TC-NER	63	4.80e-01	-0.051500	6.54e-01
HSF1 activation	27	6.44e-01	-0.051400	7.78e-01
G-protein activation	24	6.65e-01	-0.051100	7.98e-01
Positive epigenetic regulation of rRNA expression	43	5.64e-01	-0.050800	7.16e-01
G beta:gamma signalling through PLC beta	20	6.94e-01	-0.050700	8.14e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	5.85e-01	-0.050500	7.33e-01
Diseases of DNA Double-Strand Break Repair	39	5.85e-01	-0.050500	7.33e-01
RNA Polymerase II Transcription Termination	62	4.91e-01	-0.050500	6.63e-01
Purine salvage	12	7.66e-01	-0.049600	8.62e-01
HDR through Homologous Recombination (HRR)	65	4.89e-01	-0.049600	6.63e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	7.01e-01	-0.049500	8.19e-01
Signaling by NODAL	22	6.89e-01	-0.049400	8.10e-01
Removal of the Flap Intermediate	13	7.58e-01	-0.049400	8.58e-01
Cyclin A:Cdk2-associated events at S phase entry	83	4.37e-01	0.049300	6.20e-01
Methylation	14	7.49e-01	0.049300	8.53e-01
TRAF6 mediated NF-kB activation	24	6.76e-01	-0.049200	8.03e-01
Calcitonin-like ligand receptors	10	7.88e-01	-0.049100	8.79e-01
RNA Polymerase I Promoter Clearance	46	5.65e-01	-0.049000	7.17e-01
Signal regulatory protein family interactions	13	7.60e-01	0.048900	8.60e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	83	4.44e-01	-0.048600	6.25e-01
Sensory Perception	576	4.73e-02	-0.048300	1.48e-01
Keratan sulfate biosynthesis	28	6.60e-01	0.048100	7.93e-01
Termination of translesion DNA synthesis	31	6.49e-01	-0.047300	7.83e-01
G beta:gamma signalling through CDC42	19	7.22e-01	-0.047100	8.33e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	7.53e-01	-0.047000	8.55e-01
RNA Polymerase II Transcription	1271	5.21e-03	-0.046400	3.17e-02
GABA synthesis, release, reuptake and degradation	19	7.27e-01	0.046300	8.37e-01
Defects in cobalamin (B12) metabolism	12	7.82e-01	-0.046000	8.75e-01
Interleukin-12 family signaling	54	5.61e-01	0.045700	7.14e-01
Regulation of TP53 Expression and Degradation	37	6.32e-01	-0.045500	7.70e-01
Late Phase of HIV Life Cycle	126	3.80e-01	-0.045300	5.69e-01
Tight junction interactions	28	6.79e-01	-0.045200	8.05e-01
Mitotic G2-G2/M phases	178	3.00e-01	-0.045000	4.86e-01
Extension of Telomeres	48	5.90e-01	-0.045000	7.38e-01
mRNA Splicing - Major Pathway	173	3.17e-01	0.044100	4.99e-01
HDR through MMEJ (alt-NHEJ)	11	8.03e-01	-0.043400	8.93e-01
Activation of SMO	17	7.57e-01	-0.043400	8.57e-01
tRNA processing	98	4.62e-01	-0.043000	6.39e-01
Diseases associated with the TLR signaling cascade	29	6.90e-01	0.042800	8.10e-01
Diseases of Immune System	29	6.90e-01	0.042800	8.10e-01
G2/M Transition	176	3.28e-01	-0.042700	5.11e-01
Activation of the TFAP2 (AP-2) family of transcription factors	11	8.06e-01	-0.042700	8.95e-01
SHC-mediated cascade:FGFR1	21	7.36e-01	-0.042500	8.42e-01
PERK regulates gene expression	32	6.77e-01	0.042500	8.04e-01
Scavenging of heme from plasma	12	7.99e-01	-0.042500	8.89e-01
DNA Damage Bypass	46	6.18e-01	-0.042500	7.59e-01
Post-translational modification: synthesis of GPI-anchored proteins	90	4.87e-01	-0.042400	6.62e-01
Apoptotic factor-mediated response	17	7.63e-01	0.042300	8.60e-01
Telomere Extension By Telomerase	22	7.32e-01	-0.042200	8.40e-01
TICAM1, RIP1-mediated IKK complex recruitment	18	7.57e-01	-0.042200	8.57e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	7.32e-01	-0.042200	8.40e-01
tRNA processing in the nucleus	55	5.94e-01	-0.041500	7.41e-01
MyD88 cascade initiated on plasma membrane	79	5.27e-01	-0.041200	6.86e-01
Toll Like Receptor 10 (TLR10) Cascade	79	5.27e-01	-0.041200	6.86e-01
Toll Like Receptor 5 (TLR5) Cascade	79	5.27e-01	-0.041200	6.86e-01
Nuclear events stimulated by ALK signaling in cancer	18	7.63e-01	0.041100	8.60e-01
Processing of DNA double-strand break ends	61	5.80e-01	-0.040900	7.30e-01
RNA Polymerase I Transcription	47	6.28e-01	-0.040900	7.68e-01
Negative regulation of MAPK pathway	41	6.52e-01	-0.040700	7.85e-01
Lagging Strand Synthesis	19	7.61e-01	-0.040400	8.60e-01
B-WICH complex positively regulates rRNA expression	29	7.08e-01	-0.040200	8.21e-01
WNT ligand biogenesis and trafficking	25	7.28e-01	-0.040200	8.37e-01
Cellular hexose transport	21	7.52e-01	0.039900	8.55e-01
Generic Transcription Pathway	1150	2.32e-02	-0.039500	9.08e-02
Deubiquitination	230	3.01e-01	-0.039500	4.87e-01
RIP-mediated NFkB activation via ZBP1	16	7.87e-01	0.039100	8.78e-01
Toll Like Receptor 9 (TLR9) Cascade	88	5.29e-01	-0.038800	6.86e-01
Serotonin receptors	11	8.24e-01	-0.038800	9.05e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	94	5.17e-01	-0.038700	6.80e-01
Toll Like Receptor 2 (TLR2) Cascade	94	5.17e-01	-0.038700	6.80e-01
Toll Like Receptor TLR1:TLR2 Cascade	94	5.17e-01	-0.038700	6.80e-01
Toll Like Receptor TLR6:TLR2 Cascade	94	5.17e-01	-0.038700	6.80e-01
MyD88 dependent cascade initiated on endosome	84	5.45e-01	-0.038200	6.98e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	84	5.45e-01	-0.038200	6.98e-01
Defective C1GALT1C1 causes TNPS	18	7.80e-01	-0.038000	8.74e-01
Regulation of PTEN mRNA translation	25	7.43e-01	0.037800	8.47e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	7.47e-01	-0.037200	8.51e-01
Separation of Sister Chromatids	161	4.15e-01	-0.037200	6.00e-01
Regulated Necrosis	53	6.39e-01	0.037200	7.76e-01
Plasma lipoprotein clearance	37	6.98e-01	-0.036800	8.16e-01
Protein localization	147	4.42e-01	-0.036700	6.23e-01
Signaling by EGFR in Cancer	25	7.54e-01	-0.036200	8.56e-01
Negative epigenetic regulation of rRNA expression	45	6.74e-01	-0.036200	8.03e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	8.44e-01	0.036000	9.13e-01
mRNA 3’-end processing	53	6.50e-01	-0.036000	7.84e-01
Presynaptic function of Kainate receptors	21	7.76e-01	-0.035900	8.70e-01
NoRC negatively regulates rRNA expression	43	6.84e-01	-0.035800	8.08e-01
Neutrophil degranulation	458	1.88e-01	-0.035800	3.61e-01
Transcriptional regulation by RUNX3	93	5.54e-01	-0.035500	7.07e-01
Thrombin signalling through proteinase activated receptors (PARs)	32	7.28e-01	-0.035500	8.37e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77	5.94e-01	0.035100	7.41e-01
S Phase	157	4.49e-01	0.035000	6.29e-01
Downstream signaling events of B Cell Receptor (BCR)	78	5.95e-01	0.034800	7.41e-01
Interferon Signaling	194	4.03e-01	-0.034800	5.92e-01
Glycogen storage diseases	14	8.24e-01	-0.034400	9.05e-01
Biological oxidations	216	3.84e-01	-0.034400	5.73e-01
Amino acids regulate mTORC1	52	6.75e-01	-0.033600	8.03e-01
Oncogene Induced Senescence	35	7.31e-01	0.033500	8.40e-01
Processing of Capped Intron-Containing Pre-mRNA	231	3.82e-01	0.033400	5.70e-01
Synthesis of PE	12	8.41e-01	-0.033400	9.12e-01
RNA Polymerase III Transcription Termination	23	7.82e-01	-0.033300	8.75e-01
SARS-CoV-2 Infection	265	3.58e-01	-0.032800	5.45e-01
Leading Strand Synthesis	13	8.38e-01	-0.032700	9.11e-01
Polymerase switching	13	8.38e-01	-0.032700	9.11e-01
Base Excision Repair	45	7.05e-01	-0.032700	8.21e-01
RNA polymerase II transcribes snRNA genes	77	6.25e-01	-0.032200	7.66e-01
Signalling to ERKs	34	7.45e-01	-0.032200	8.49e-01
TNFR1-induced proapoptotic signaling	13	8.42e-01	0.032000	9.12e-01
Budding and maturation of HIV virion	28	7.70e-01	-0.031900	8.65e-01
CYP2E1 reactions	11	8.55e-01	0.031800	9.16e-01
Transcriptional Regulation by VENTX	41	7.24e-01	-0.031800	8.35e-01
Complex I biogenesis	49	7.00e-01	0.031800	8.18e-01
Host Interactions of HIV factors	122	5.44e-01	-0.031800	6.98e-01
Formation of TC-NER Pre-Incision Complex	51	6.97e-01	0.031500	8.16e-01
Peptide ligand-binding receptors	190	4.54e-01	-0.031500	6.33e-01
Regulation of signaling by NODAL	11	8.57e-01	0.031400	9.17e-01
ER Quality Control Compartment (ERQC)	20	8.08e-01	0.031300	8.95e-01
Innate Immune System	999	9.61e-02	-0.031000	2.32e-01
Phospholipase C-mediated cascade: FGFR1	16	8.30e-01	-0.031000	9.08e-01
Transcription of the HIV genome	62	6.76e-01	0.030700	8.03e-01
Attenuation phase	25	7.91e-01	-0.030600	8.82e-01
Processive synthesis on the lagging strand	14	8.44e-01	-0.030300	9.13e-01
Dissolution of Fibrin Clot	13	8.51e-01	0.030200	9.15e-01
PCNA-Dependent Long Patch Base Excision Repair	21	8.11e-01	-0.030100	8.95e-01
Digestion of dietary carbohydrate	10	8.71e-01	-0.029700	9.25e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	7.57e-01	0.029400	8.57e-01
Regulation of RUNX2 expression and activity	71	6.70e-01	0.029300	8.01e-01
Dermatan sulfate biosynthesis	10	8.74e-01	-0.028900	9.27e-01
Transport of organic anions	10	8.74e-01	-0.028900	9.27e-01
Glucocorticoid biosynthesis	10	8.76e-01	-0.028500	9.27e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	31	7.85e-01	0.028400	8.76e-01
Selective autophagy	59	7.06e-01	-0.028400	8.21e-01
The citric acid (TCA) cycle and respiratory electron transport	143	5.67e-01	0.027700	7.17e-01
Glyoxylate metabolism and glycine degradation	30	7.93e-01	-0.027700	8.83e-01
Fanconi Anemia Pathway	37	7.71e-01	0.027700	8.65e-01
TNFs bind their physiological receptors	25	8.12e-01	0.027500	8.95e-01
Nucleotide salvage	21	8.32e-01	0.026800	9.08e-01
Cytochrome P450 - arranged by substrate type	64	7.13e-01	-0.026600	8.25e-01
Metal ion SLC transporters	25	8.18e-01	0.026600	9.01e-01
Telomere C-strand synthesis initiation	11	8.80e-01	-0.026300	9.27e-01
Chemokine receptors bind chemokines	56	7.36e-01	-0.026000	8.42e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	8.50e-01	0.025700	9.15e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	8.31e-01	-0.025700	9.08e-01
Defective GALNT12 causes CRCS1	18	8.51e-01	-0.025600	9.15e-01
Chylomicron remodeling	10	8.91e-01	0.025000	9.31e-01
HIV Life Cycle	139	6.14e-01	-0.024700	7.56e-01
Signaling by NOTCH4	79	7.05e-01	0.024600	8.21e-01
Regulation of TNFR1 signaling	32	8.10e-01	-0.024600	8.95e-01
Dectin-2 family	28	8.28e-01	-0.023600	9.08e-01
Metabolism of amino acids and derivatives	345	4.51e-01	0.023600	6.30e-01
Gap junction assembly	18	8.63e-01	0.023500	9.21e-01
Arachidonic acid metabolism	56	7.64e-01	-0.023200	8.61e-01
Mitophagy	27	8.35e-01	-0.023200	9.11e-01
Calnexin/calreticulin cycle	25	8.41e-01	0.023100	9.12e-01
Tandem pore domain potassium channels	12	8.90e-01	-0.023100	9.31e-01
Signalling to RAS	20	8.60e-01	0.022800	9.19e-01
Mitotic Metaphase and Anaphase	222	5.58e-01	-0.022800	7.11e-01
RNA Polymerase I Promoter Escape	28	8.37e-01	0.022400	9.11e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	23	8.53e-01	-0.022400	9.15e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	23	8.53e-01	-0.022400	9.15e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	23	8.53e-01	-0.022400	9.15e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	23	8.53e-01	-0.022400	9.15e-01
Impaired BRCA2 binding to PALB2	23	8.53e-01	-0.022400	9.15e-01
Interleukin-1 signaling	97	7.06e-01	0.022200	8.21e-01
IL-6-type cytokine receptor ligand interactions	17	8.75e-01	-0.022100	9.27e-01
SARS-CoV-2-host interactions	185	6.08e-01	0.021800	7.50e-01
FCGR activation	12	8.96e-01	-0.021800	9.34e-01
Chaperone Mediated Autophagy	19	8.71e-01	0.021500	9.25e-01
Glycogen metabolism	24	8.57e-01	-0.021300	9.17e-01
HIV Transcription Initiation	43	8.10e-01	0.021100	8.95e-01
RNA Polymerase II HIV Promoter Escape	43	8.10e-01	0.021100	8.95e-01
RNA Polymerase II Promoter Escape	43	8.10e-01	0.021100	8.95e-01
RNA Polymerase II Transcription Initiation	43	8.10e-01	0.021100	8.95e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	8.10e-01	0.021100	8.95e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	8.10e-01	0.021100	8.95e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	8.29e-01	-0.020800	9.08e-01
RNA Polymerase III Chain Elongation	18	8.80e-01	0.020500	9.27e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	31	8.46e-01	-0.020200	9.14e-01
Cleavage of the damaged pyrimidine	16	8.89e-01	0.020200	9.31e-01
Depyrimidination	16	8.89e-01	0.020200	9.31e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	8.89e-01	0.020200	9.31e-01
DAP12 interactions	40	8.25e-01	0.020200	9.06e-01
Synthesis of glycosylphosphatidylinositol (GPI)	17	8.86e-01	0.020100	9.31e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	7.84e-01	-0.020100	8.76e-01
Translesion synthesis by POLI	17	8.87e-01	-0.020000	9.31e-01
Mitotic Anaphase	221	6.10e-01	-0.019900	7.50e-01
Mitotic G1 phase and G1/S transition	144	6.86e-01	-0.019500	8.09e-01
Inhibition of DNA recombination at telomere	20	8.80e-01	0.019500	9.27e-01
Transferrin endocytosis and recycling	30	8.53e-01	-0.019500	9.15e-01
Cytoprotection by HMOX1	58	8.00e-01	-0.019200	8.90e-01
Insulin receptor recycling	25	8.68e-01	0.019200	9.24e-01
PINK1-PRKN Mediated Mitophagy	21	8.79e-01	0.019100	9.27e-01
KEAP1-NFE2L2 pathway	103	7.37e-01	0.019100	8.42e-01
Keratan sulfate/keratin metabolism	33	8.50e-01	-0.019000	9.15e-01
Interleukin-1 family signaling	134	7.07e-01	-0.018800	8.21e-01
Degradation of beta-catenin by the destruction complex	81	7.70e-01	-0.018800	8.65e-01
Aggrephagy	23	8.78e-01	0.018500	9.27e-01
Glutamate and glutamine metabolism	12	9.12e-01	0.018400	9.47e-01
Downregulation of ERBB2 signaling	28	8.67e-01	-0.018300	9.24e-01
mRNA decay by 3’ to 5’ exoribonuclease	16	9.00e-01	-0.018100	9.37e-01
TNF signaling	40	8.44e-01	-0.018000	9.13e-01
Interconversion of nucleotide di- and triphosphates	29	8.70e-01	-0.017600	9.25e-01
Regulation of TP53 Activity	154	7.08e-01	-0.017500	8.21e-01
HIV Infection	216	6.58e-01	-0.017500	7.91e-01
Cytokine Signaling in Immune system	667	4.52e-01	-0.017000	6.30e-01
FGFRL1 modulation of FGFR1 signaling	13	9.16e-01	-0.016900	9.50e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	9.17e-01	-0.016600	9.50e-01
Interleukin-2 signaling	11	9.25e-01	0.016500	9.55e-01
Cargo concentration in the ER	32	8.78e-01	-0.015700	9.27e-01
Nuclear Envelope (NE) Reassembly	73	8.20e-01	-0.015400	9.02e-01
Telomere Maintenance	62	8.36e-01	-0.015200	9.11e-01
TP53 Regulates Transcription of Cell Death Genes	42	8.68e-01	-0.014900	9.24e-01
Translesion synthesis by POLK	17	9.21e-01	-0.013900	9.53e-01
Biosynthesis of specialized proresolving mediators (SPMs)	19	9.17e-01	0.013900	9.50e-01
Phase I - Functionalization of compounds	100	8.12e-01	-0.013700	8.95e-01
DNA Damage/Telomere Stress Induced Senescence	28	9.01e-01	-0.013600	9.37e-01
Ub-specific processing proteases	157	7.69e-01	-0.013600	8.65e-01
Mitochondrial protein import	54	8.63e-01	-0.013500	9.21e-01
Unfolded Protein Response (UPR)	91	8.31e-01	0.012900	9.08e-01
TP53 Regulates Transcription of Cell Cycle Genes	49	8.79e-01	0.012500	9.27e-01
Formation of HIV elongation complex in the absence of HIV Tat	40	8.91e-01	-0.012500	9.31e-01
RHOH GTPase cycle	36	8.98e-01	0.012400	9.36e-01
XBP1(S) activates chaperone genes	48	8.83e-01	-0.012300	9.29e-01
Class B/2 (Secretin family receptors)	94	8.38e-01	-0.012200	9.11e-01
FGFR1 ligand binding and activation	15	9.36e-01	-0.012000	9.65e-01
Surfactant metabolism	29	9.11e-01	0.012000	9.47e-01
Nucleotide Excision Repair	107	8.39e-01	-0.011300	9.11e-01
ZBP1(DAI) mediated induction of type I IFNs	20	9.30e-01	-0.011300	9.61e-01
Keratinization	214	7.78e-01	-0.011200	8.72e-01
IRE1alpha activates chaperones	50	8.92e-01	-0.011100	9.32e-01
RAB geranylgeranylation	57	8.87e-01	0.010900	9.31e-01
Resolution of Abasic Sites (AP sites)	37	9.12e-01	-0.010500	9.47e-01
CLEC7A (Dectin-1) signaling	96	8.61e-01	0.010400	9.20e-01
ATF4 activates genes in response to endoplasmic reticulum stress	28	9.25e-01	0.010300	9.55e-01
Degradation of cysteine and homocysteine	14	9.49e-01	0.009880	9.74e-01
Signaling by Interleukins	426	7.28e-01	-0.009810	8.37e-01
Base-Excision Repair, AP Site Formation	18	9.45e-01	0.009330	9.72e-01
Cellular response to chemical stress	187	8.31e-01	-0.009050	9.08e-01
PTEN Regulation	150	8.52e-01	0.008840	9.15e-01
G1/S Transition	126	8.68e-01	-0.008580	9.24e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	9.52e-01	-0.008490	9.76e-01
TP53 Regulates Metabolic Genes	83	8.94e-01	0.008440	9.33e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	9.01e-01	-0.008280	9.37e-01
Post-chaperonin tubulin folding pathway	23	9.47e-01	-0.008030	9.73e-01
Signaling by the B Cell Receptor (BCR)	105	8.87e-01	-0.008010	9.31e-01
VLDLR internalisation and degradation	16	9.57e-01	-0.007750	9.80e-01
SUMOylation of transcription factors	20	9.53e-01	-0.007670	9.76e-01
Downregulation of ERBB2:ERBB3 signaling	13	9.62e-01	-0.007560	9.81e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	9.50e-01	0.007240	9.75e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	9.63e-01	-0.007210	9.81e-01
Transcriptional Regulation by TP53	346	8.29e-01	-0.006770	9.08e-01
Defective GALNT3 causes HFTC	18	9.62e-01	0.006480	9.81e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	9.71e-01	-0.005980	9.87e-01
Regulation of PTEN stability and activity	66	9.34e-01	0.005870	9.64e-01
Iron uptake and transport	57	9.40e-01	-0.005800	9.68e-01
Cytosolic sensors of pathogen-associated DNA	60	9.46e-01	0.005080	9.72e-01
C-type lectin receptors (CLRs)	137	9.18e-01	-0.005080	9.51e-01
TAK1-dependent IKK and NF-kappa-B activation	25	9.66e-01	0.004960	9.83e-01
Regulation of TLR by endogenous ligand	17	9.72e-01	-0.004950	9.87e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	38	9.63e-01	-0.004380	9.81e-01
HIV Transcription Elongation	38	9.63e-01	-0.004380	9.81e-01
Tat-mediated elongation of the HIV-1 transcript	38	9.63e-01	-0.004380	9.81e-01
PCP/CE pathway	90	9.46e-01	0.004170	9.72e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	38	9.65e-01	-0.004120	9.83e-01
Assembly of active LPL and LIPC lipase complexes	17	9.77e-01	0.003960	9.88e-01
RHO GTPases Activate NADPH Oxidases	22	9.75e-01	-0.003850	9.88e-01
Organic anion transporters	10	9.83e-01	0.003780	9.91e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	9.71e-01	0.003570	9.87e-01
Global Genome Nucleotide Excision Repair (GG-NER)	81	9.58e-01	0.003350	9.81e-01
DNA strand elongation	31	9.75e-01	-0.003220	9.88e-01
Cellular responses to stimuli	697	8.88e-01	0.003120	9.31e-01
Diseases of mitotic cell cycle	37	9.75e-01	0.002930	9.88e-01
Regulation of RUNX1 Expression and Activity	25	9.82e-01	0.002560	9.91e-01
Nucleotide biosynthesis	14	9.87e-01	0.002490	9.92e-01
NOD1/2 Signaling Pathway	29	9.83e-01	-0.002330	9.91e-01
Hedgehog ‘on’ state	83	9.71e-01	-0.002320	9.87e-01
Late endosomal microautophagy	32	9.84e-01	0.002090	9.91e-01
RNA Polymerase II Pre-transcription Events	73	9.76e-01	-0.002070	9.88e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	9.90e-01	0.001860	9.93e-01
Regulation of BACH1 activity	15	9.91e-01	0.001690	9.94e-01
Interleukin-4 and Interleukin-13 signaling	104	9.77e-01	0.001640	9.88e-01
Regulation of PTEN gene transcription	59	9.85e-01	0.001420	9.92e-01
Negative regulation of FGFR1 signaling	32	9.90e-01	0.001280	9.93e-01
TP53 Regulates Transcription of DNA Repair Genes	57	9.87e-01	0.001230	9.92e-01
ABC transporter disorders	75	9.88e-01	0.001040	9.92e-01
G2/M Checkpoints	129	9.86e-01	0.000879	9.92e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	9.96e-01	0.000874	9.97e-01
Processing and activation of SUMO	10	9.97e-01	-0.000650	9.98e-01
Formation of tubulin folding intermediates by CCT/TriC	26	9.96e-01	-0.000545	9.97e-01
Cellular responses to stress	683	9.83e-01	-0.000482	9.91e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	9.98e-01	0.000238	9.98e-01

---

Detailed Gene set reports

DCC mediated attractive signaling

DCC mediated attractive signaling

	259
set	DCC mediated attractive signaling
setSize	14
pANOVA	1.31e-05
s.dist	-0.673
p.adjustANOVA	0.000222

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PTK2	-22858.5
TRIO	-22851.5
DOCK1	-22742.5
FYN	-22583.5
WASL	-21945.5
ABLIM2	-20966.5
DCC	-20296.5
NTN1	-20249.5
NCK1	-19529.5
ABLIM3	-19394.5
ABLIM1	-19162.5
RAC1	-15917.5
SRC	-8349.5
CDC42	-3639.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PTK2	-22858.5
TRIO	-22851.5
DOCK1	-22742.5
FYN	-22583.5
WASL	-21945.5
ABLIM2	-20966.5
DCC	-20296.5
NTN1	-20249.5
NCK1	-19529.5
ABLIM3	-19394.5
ABLIM1	-19162.5
RAC1	-15917.5
SRC	-8349.5
CDC42	-3639.5

---

Activation of RAC1

Activation of RAC1

	48
set	Activation of RAC1
setSize	11
pANOVA	0.000522
s.dist	-0.604
p.adjustANOVA	0.00508

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ROBO1	-22135.5
SOS1	-21862.5
SLIT2	-21813.5
PAK6	-19827.5
NCK2	-19780.5
NCK1	-19529.5
SOS2	-16162.5
RAC1	-15917.5
PAK4	-14718.5
PAK1	-14690.5
PAK2	-8359.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ROBO1	-22135.5
SOS1	-21862.5
SLIT2	-21813.5
PAK6	-19827.5
NCK2	-19780.5
NCK1	-19529.5
SOS2	-16162.5
RAC1	-15917.5
PAK4	-14718.5
PAK1	-14690.5
PAK2	-8359.5

---

Regulation of commissural axon pathfinding by SLIT and ROBO

Regulation of commissural axon pathfinding by SLIT and ROBO

	1104
set	Regulation of commissural axon pathfinding by SLIT and ROBO
setSize	10
pANOVA	0.00258
s.dist	-0.55
p.adjustANOVA	0.0185

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLIT3	-22399.5
ROBO1	-22135.5
SLIT2	-21813.5
ROBO2	-21154.5
DCC	-20296.5
NTN1	-20249.5
NELL2	-17326.5
SLIT1	-8838.5
SRC	-8349.5
ROBO3	-7529.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLIT3	-22399.5
ROBO1	-22135.5
SLIT2	-21813.5
ROBO2	-21154.5
DCC	-20296.5
NTN1	-20249.5
NELL2	-17326.5
SLIT1	-8838.5
SRC	-8349.5
ROBO3	-7529.5

---

Interaction between L1 and Ankyrins

Interaction between L1 and Ankyrins

	612
set	Interaction between L1 and Ankyrins
setSize	28
pANOVA	1.43e-06
s.dist	-0.526
p.adjustANOVA	3.78e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ANK2	-22800.5
ANK3	-22789.5
SPTBN1	-22297.5
SCN8A	-22288.5
SCN1A	-21860.5
SCN2A	-21843.5
NRCAM	-21726.5
SCN7A	-20783.5
NFASC	-20779.5
ANK1	-20590.5
SPTA1	-20257.5
SCN11A	-20045.5
SCN9A	-19777.5
SCN3A	-18434.5
KCNQ2	-18242.5
SPTB	-17430.5
SPTBN2	-17003.5
SCN1B	-16969.5
SCN4A	-16429.5
SPTBN4	-14396.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ANK2	-22800.5
ANK3	-22789.5
SPTBN1	-22297.5
SCN8A	-22288.5
SCN1A	-21860.5
SCN2A	-21843.5
NRCAM	-21726.5
SCN7A	-20783.5
NFASC	-20779.5
ANK1	-20590.5
SPTA1	-20257.5
SCN11A	-20045.5
SCN9A	-19777.5
SCN3A	-18434.5
KCNQ2	-18242.5
SPTB	-17430.5
SPTBN2	-17003.5
SCN1B	-16969.5
SCN4A	-16429.5
SPTBN4	-14396.5
SCN5A	-14014.5
SPTBN5	-13649.5
SCN10A	-12460.5
SCN2B	-10983.5
SCN4B	-9166.5
KCNQ3	-4891.5
SCN3B	-2829.5
SPTAN1	-2501.5

---

Apoptotic cleavage of cell adhesion proteins

Apoptotic cleavage of cell adhesion proteins

	88
set	Apoptotic cleavage of cell adhesion proteins
setSize	11
pANOVA	0.00315
s.dist	-0.514
p.adjustANOVA	0.0212

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DSG1	-21551.5
TJP1	-21510.5
OCLN	-19862.5
DSP	-19346.5
DSG2	-19318.5
DSG3	-17027.5
PKP1	-15246.5
TJP2	-14923.5
CDH1	-14357.5
CTNNB1	-13068.5
CASP3	-5657.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DSG1	-21551.5
TJP1	-21510.5
OCLN	-19862.5
DSP	-19346.5
DSG2	-19318.5
DSG3	-17027.5
PKP1	-15246.5
TJP2	-14923.5
CDH1	-14357.5
CTNNB1	-13068.5
CASP3	-5657.5

---

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

	1159
set	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
setSize	13
pANOVA	0.00135
s.dist	-0.513
p.adjustANOVA	0.0107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FYN	-22583.5
NRP1	-22467.5
PLXNA4	-22093.5
PLXNA2	-21764.5
SEMA3A	-20560.5
PIP5K1C	-18799.5
PLXNA1	-17310.5
RAC1	-15917.5
FARP2	-14116.5
TLN1	-13757.5
RND1	-13551.5
FES	-10813.5
RRAS	-1075.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FYN	-22583.5
NRP1	-22467.5
PLXNA4	-22093.5
PLXNA2	-21764.5
SEMA3A	-20560.5
PIP5K1C	-18799.5
PLXNA1	-17310.5
RAC1	-15917.5
FARP2	-14116.5
TLN1	-13757.5
RND1	-13551.5
FES	-10813.5
RRAS	-1075.5

---

Nephrin family interactions

Nephrin family interactions

	805
set	Nephrin family interactions
setSize	21
pANOVA	6.08e-05
s.dist	-0.505
p.adjustANOVA	0.000781

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAGI2	-22766.5
FYN	-22583.5
PIK3CB	-22349.5
SPTBN1	-22297.5
WASL	-21945.5
KIRREL	-21402.5
ACTN2	-21206.5
CD2AP	-20771.5
PIK3R2	-20729.5
IQGAP1	-20644.5
NCK2	-19780.5
NCK1	-19529.5
ACTN3	-19259.5
KIRREL3	-16756.5
PIK3R1	-12629.5
PIK3CA	-11952.5
ACTN4	-11680.5
ACTN1	-8435.5
NPHS1	-7290.5
SPTAN1	-2501.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAGI2	-22766.5
FYN	-22583.5
PIK3CB	-22349.5
SPTBN1	-22297.5
WASL	-21945.5
KIRREL	-21402.5
ACTN2	-21206.5
CD2AP	-20771.5
PIK3R2	-20729.5
IQGAP1	-20644.5
NCK2	-19780.5
NCK1	-19529.5
ACTN3	-19259.5
KIRREL3	-16756.5
PIK3R1	-12629.5
PIK3CA	-11952.5
ACTN4	-11680.5
ACTN1	-8435.5
NPHS1	-7290.5
SPTAN1	-2501.5
KIRREL2	1751.5

---

Adenylate cyclase activating pathway

Adenylate cyclase activating pathway

	64
set	Adenylate cyclase activating pathway
setSize	10
pANOVA	0.00584
s.dist	-0.503
p.adjustANOVA	0.0346

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADCY2	-21801.5
ADCY1	-20495.5
GNAL	-19877.5
ADCY3	-19801.5
ADCY8	-19735.5
ADCY5	-17837.5
ADCY7	-15087.5
ADCY9	-12308.5
ADCY4	-11594.5
ADCY6	-5400.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADCY2	-21801.5
ADCY1	-20495.5
GNAL	-19877.5
ADCY3	-19801.5
ADCY8	-19735.5
ADCY5	-17837.5
ADCY7	-15087.5
ADCY9	-12308.5
ADCY4	-11594.5
ADCY6	-5400.5

---

NRAGE signals death through JNK

NRAGE signals death through JNK

	785
set	NRAGE signals death through JNK
setSize	53
pANOVA	3.21e-10
s.dist	-0.499
p.adjustANOVA	2.23e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRIO	-22851.5
AKAP13	-22714.5
KALRN	-22704.5
MCF2L	-22690.5
ARHGEF7	-22679.5
ITSN1	-22587.5
ARHGEF10	-22462.5
TIAM2	-22439.5
ARHGEF12	-22397.5
NGEF	-21939.5
ABR	-21896.5
SOS1	-21862.5
RASGRF2	-21838.5
ARHGEF19	-21788.5
VAV3	-21690.5
FGD4	-21485.5
TIAM1	-21450.5
MAPK8	-21190.5
PLEKHG5	-20028.5
ARHGEF33	-19579.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRIO	-22851.5
AKAP13	-22714.5
KALRN	-22704.5
MCF2L	-22690.5
ARHGEF7	-22679.5
ITSN1	-22587.5
ARHGEF10	-22462.5
TIAM2	-22439.5
ARHGEF12	-22397.5
NGEF	-21939.5
ABR	-21896.5
SOS1	-21862.5
RASGRF2	-21838.5
ARHGEF19	-21788.5
VAV3	-21690.5
FGD4	-21485.5
TIAM1	-21450.5
MAPK8	-21190.5
PLEKHG5	-20028.5
ARHGEF33	-19579.5
ARHGEF3	-19209.5
ECT2	-18793.5
OBSCN	-18674.5
FGD2	-18657.5
ARHGEF11	-18655.5
ARHGEF26	-18617.5
AATF	-18387.5
VAV2	-18383.5
ARHGEF2	-17908.5
NGF	-17878.5
VAV1	-16979.5
BAD	-16947.5
SOS2	-16162.5
RAC1	-15917.5
ARHGEF18	-15853.5
NET1	-15668.5
ARHGEF37	-15487.5
GNA13	-14814.5
PREX1	-14795.5
ARHGEF38	-14596.5
ARHGEF17	-14115.5
BCL2L11	-13108.5
ARHGEF10L	-11503.5
FGD3	-9371.5
ARHGEF39	-9092.5
ARHGEF5	-7332.5
ARHGEF4	-7149.5
ARHGEF1	-6127.5
ARHGEF16	-5900.5
ARHGEF40	-2301.5
ARHGEF15	-1211.5
NGFR	1133.5
PLEKHG2	1398.5

---

cGMP effects

cGMP effects

	1499
set	cGMP effects
setSize	15
pANOVA	0.000881
s.dist	-0.496
p.adjustANOVA	0.00757

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KCNMA1	-22857.5
PDE10A	-22652.5
ITPR1	-22364.5
PDE11A	-22329.5
PDE1A	-22079.5
PRKG1	-22007.5
KCNMB3	-21754.5
PDE5A	-20877.5
KCNMB2	-20121.5
PRKG2	-15673.5
PDE9A	-8546.5
PDE1B	-6711.5
PDE2A	-6602.5
KCNMB4	-6065.5
KCNMB1	-3794.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KCNMA1	-22857.5
PDE10A	-22652.5
ITPR1	-22364.5
PDE11A	-22329.5
PDE1A	-22079.5
PRKG1	-22007.5
KCNMB3	-21754.5
PDE5A	-20877.5
KCNMB2	-20121.5
PRKG2	-15673.5
PDE9A	-8546.5
PDE1B	-6711.5
PDE2A	-6602.5
KCNMB4	-6065.5
KCNMB1	-3794.5

---

Defective EXT1 causes exostoses 1, TRPS2 and CHDS

Defective EXT1 causes exostoses 1, TRPS2 and CHDS

	283
set	Defective EXT1 causes exostoses 1, TRPS2 and CHDS
setSize	12
pANOVA	0.00299
s.dist	-0.495
p.adjustANOVA	0.0205

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EXT1	-22861.5
SDC2	-22650.5
GPC6	-22631.5
EXT2	-22268.5
GPC5	-22081.5
HSPG2	-20428.5
GPC1	-17587.5
AGRN	-16966.5
SDC3	-15262.5
SDC1	-7540.5
SDC4	-3699.5
GPC2	-1413.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EXT1	-22861.5
SDC2	-22650.5
GPC6	-22631.5
EXT2	-22268.5
GPC5	-22081.5
HSPG2	-20428.5
GPC1	-17587.5
AGRN	-16966.5
SDC3	-15262.5
SDC1	-7540.5
SDC4	-3699.5
GPC2	-1413.5

---

Defective EXT2 causes exostoses 2

Defective EXT2 causes exostoses 2

	284
set	Defective EXT2 causes exostoses 2
setSize	12
pANOVA	0.00299
s.dist	-0.495
p.adjustANOVA	0.0205

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EXT1	-22861.5
SDC2	-22650.5
GPC6	-22631.5
EXT2	-22268.5
GPC5	-22081.5
HSPG2	-20428.5
GPC1	-17587.5
AGRN	-16966.5
SDC3	-15262.5
SDC1	-7540.5
SDC4	-3699.5
GPC2	-1413.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EXT1	-22861.5
SDC2	-22650.5
GPC6	-22631.5
EXT2	-22268.5
GPC5	-22081.5
HSPG2	-20428.5
GPC1	-17587.5
AGRN	-16966.5
SDC3	-15262.5
SDC1	-7540.5
SDC4	-3699.5
GPC2	-1413.5

---

EGR2 and SOX10-mediated initiation of Schwann cell myelination

EGR2 and SOX10-mediated initiation of Schwann cell myelination

	362
set	EGR2 and SOX10-mediated initiation of Schwann cell myelination
setSize	27
pANOVA	2.19e-05
s.dist	-0.472
p.adjustANOVA	0.000342

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UTRN	-22864.5
WWTR1	-22688.5
DAG1	-22378.5
SCD5	-22281.5
LAMA2	-22129.5
TEAD1	-21985.5
LAMB1	-21859.5
ADGRV1	-21415.5
SMARCA4	-21338.5
MBP	-20630.5
NAB1	-20550.5
PRX	-20321.5
ADGRG6	-19928.5
EGR2	-19024.5
LAMC1	-18518.5
CYP51A1	-18146.5
HMGCR	-18047.5
YAP1	-17250.5
PMP22	-16341.5
SREBF2	-12071.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UTRN	-22864.5
WWTR1	-22688.5
DAG1	-22378.5
SCD5	-22281.5
LAMA2	-22129.5
TEAD1	-21985.5
LAMB1	-21859.5
ADGRV1	-21415.5
SMARCA4	-21338.5
MBP	-20630.5
NAB1	-20550.5
PRX	-20321.5
ADGRG6	-19928.5
EGR2	-19024.5
LAMC1	-18518.5
CYP51A1	-18146.5
HMGCR	-18047.5
YAP1	-17250.5
PMP22	-16341.5
SREBF2	-12071.5
HDAC2	-10649.5
POU3F1	-8262.5
MAG	-5925.5
POU3F2	-5616.5
NAB2	-1475.5
MPZ	-1278.5
SOX10	1584.5

---

PKA activation in glucagon signalling

PKA activation in glucagon signalling

	879
set	PKA activation in glucagon signalling
setSize	17
pANOVA	0.000779
s.dist	-0.471
p.adjustANOVA	0.00692

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GNAS	-22374.5
ADCY2	-21801.5
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY3	-19801.5
ADCY8	-19735.5
PRKAR1A	-18982.5
ADCY5	-17837.5
PRKACG	-17006.5
PRKAR2A	-15395.5
PRKAR2B	-15391.5
ADCY7	-15087.5
ADCY9	-12308.5
ADCY4	-11594.5
ADCY6	-5400.5
PRKACA	2274.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GNAS	-22374.5
ADCY2	-21801.5
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY3	-19801.5
ADCY8	-19735.5
PRKAR1A	-18982.5
ADCY5	-17837.5
PRKACG	-17006.5
PRKAR2A	-15395.5
PRKAR2B	-15391.5
ADCY7	-15087.5
ADCY9	-12308.5
ADCY4	-11594.5
ADCY6	-5400.5
PRKACA	2274.5

---

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

	1333
set	Synthesis of bile acids and bile salts via 27-hydroxycholesterol
setSize	15
pANOVA	0.00167
s.dist	-0.469
p.adjustANOVA	0.0127

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCOA2	-22661.5
AKR1C2	-22459.5
NCOA1	-22042.5
AKR1C4	-21179.5
AKR1C3	-21112.5
AKR1D1	-20446.5
CYP7B1	-20172.5
AKR1C1	-18478.5
PTGIS	-18422.5
NR1H4	-15969.5
CYP7A1	-11902.5
CYP8B1	-10019.5
CYP27A1	-6710.5
RXRA	-4378.5
HSD3B7	-3171.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCOA2	-22661.5
AKR1C2	-22459.5
NCOA1	-22042.5
AKR1C4	-21179.5
AKR1C3	-21112.5
AKR1D1	-20446.5
CYP7B1	-20172.5
AKR1C1	-18478.5
PTGIS	-18422.5
NR1H4	-15969.5
CYP7A1	-11902.5
CYP8B1	-10019.5
CYP27A1	-6710.5
RXRA	-4378.5
HSD3B7	-3171.5

---

Organic cation transport

Organic cation transport

	853
set	Organic cation transport
setSize	10
pANOVA	0.0103
s.dist	-0.468
p.adjustANOVA	0.0517

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC22A18	-21633.5
SLC22A5	-20610.5
SLC22A15	-19212.5
SLC22A16	-18805.5
SLC22A3	-16189.5
RUNX1	-16186.5
SLC22A1	-15819.5
SLC22A2	-14055.5
RSC1A1	-12938.5
SLC22A4	-3927.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC22A18	-21633.5
SLC22A5	-20610.5
SLC22A15	-19212.5
SLC22A16	-18805.5
SLC22A3	-16189.5
RUNX1	-16186.5
SLC22A1	-15819.5
SLC22A2	-14055.5
RSC1A1	-12938.5
SLC22A4	-3927.5

---

Adherens junctions interactions

Adherens junctions interactions

	66
set	Adherens junctions interactions
setSize	26
pANOVA	3.81e-05
s.dist	-0.466
p.adjustANOVA	0.000511

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTNNA1	-22734.5
CDH18	-22617.5
CTNND1	-22230.5
CDH2	-21869.5
CADM2	-21293.5
CDH17	-20149.5
CDH6	-20033.5
CADM1	-19903.5
CDH5	-19850.5
PVR	-19670.5
CDH24	-19213.5
CDH10	-17960.5
CDH12	-17544.5
CDH11	-17098.5
CDH13	-16659.5
CDH3	-15025.5
CDH9	-15006.5
CDH1	-14357.5
CTNNB1	-13068.5
CDH8	-12775.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTNNA1	-22734.5
CDH18	-22617.5
CTNND1	-22230.5
CDH2	-21869.5
CADM2	-21293.5
CDH17	-20149.5
CDH6	-20033.5
CADM1	-19903.5
CDH5	-19850.5
PVR	-19670.5
CDH24	-19213.5
CDH10	-17960.5
CDH12	-17544.5
CDH11	-17098.5
CDH13	-16659.5
CDH3	-15025.5
CDH9	-15006.5
CDH1	-14357.5
CTNNB1	-13068.5
CDH8	-12775.5
CDH4	-11660.5
JUP	-10337.5
ANG	-7617.5
CADM3	-7551.5
CDH7	-5313.5
CDH15	-2102.5

---

Role of LAT2/NTAL/LAB on calcium mobilization

Role of LAT2/NTAL/LAB on calcium mobilization

	1146
set	Role of LAT2/NTAL/LAB on calcium mobilization
setSize	13
pANOVA	0.0045
s.dist	-0.455
p.adjustANOVA	0.0279

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FYN	-22583.5
PIK3CB	-22349.5
SOS1	-21862.5
PIK3R2	-20729.5
GAB2	-19959.5
LYN	-18170.5
PDPK1	-15745.5
SHC1	-12689.5
PIK3R1	-12629.5
PIK3CA	-11952.5
LAT2	-10826.5
GRB2	-8843.5
SYK	-6568.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FYN	-22583.5
PIK3CB	-22349.5
SOS1	-21862.5
PIK3R2	-20729.5
GAB2	-19959.5
LYN	-18170.5
PDPK1	-15745.5
SHC1	-12689.5
PIK3R1	-12629.5
PIK3CA	-11952.5
LAT2	-10826.5
GRB2	-8843.5
SYK	-6568.5

---

Signaling by Hippo

Signaling by Hippo

	1251
set	Signaling by Hippo
setSize	19
pANOVA	0.000646
s.dist	-0.452
p.adjustANOVA	0.00605

Top enriched genes

Top 20 genes

GeneID	Gene Rank
WWTR1	-22688.5
NPHP4	-22668.5
AMOTL2	-22386.5
STK3	-22189.5
TJP1	-21510.5
AMOTL1	-21366.5
LATS2	-19372.5
MOB1B	-18397.5
YAP1	-17250.5
YWHAE	-16248.5
YWHAB	-15665.5
TJP2	-14923.5
LATS1	-14791.5
WWC1	-14679.5
STK4	-11423.5
SAV1	-11315.5
CASP3	-5657.5
MOB1A	-3283.5
DVL2	-2888.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
WWTR1	-22688.5
NPHP4	-22668.5
AMOTL2	-22386.5
STK3	-22189.5
TJP1	-21510.5
AMOTL1	-21366.5
LATS2	-19372.5
MOB1B	-18397.5
YAP1	-17250.5
YWHAE	-16248.5
YWHAB	-15665.5
TJP2	-14923.5
LATS1	-14791.5
WWC1	-14679.5
STK4	-11423.5
SAV1	-11315.5
CASP3	-5657.5
MOB1A	-3283.5
DVL2	-2888.5

---

Trafficking of GluR2-containing AMPA receptors

Trafficking of GluR2-containing AMPA receptors

	1408
set	Trafficking of GluR2-containing AMPA receptors
setSize	15
pANOVA	0.00305
s.dist	-0.442
p.adjustANOVA	0.0208

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKCA	-22831.5
GRIP1	-22814.5
AP2A2	-21576.5
NSF	-21284.5
GRIA4	-20998.5
GRIA1	-19700.5
AP2B1	-18472.5
AP2A1	-16304.5
AP2M1	-15984.5
PRKCB	-12428.5
GRIP2	-12278.5
GRIA2	-10616.5
AP2S1	-7060.5
PICK1	-6777.5
PRKCG	-4694.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKCA	-22831.5
GRIP1	-22814.5
AP2A2	-21576.5
NSF	-21284.5
GRIA4	-20998.5
GRIA1	-19700.5
AP2B1	-18472.5
AP2A1	-16304.5
AP2M1	-15984.5
PRKCB	-12428.5
GRIP2	-12278.5
GRIA2	-10616.5
AP2S1	-7060.5
PICK1	-6777.5
PRKCG	-4694.5

---

MET activates PTK2 signaling

MET activates PTK2 signaling

	691
set	MET activates PTK2 signaling
setSize	18
pANOVA	0.0012
s.dist	-0.441
p.adjustANOVA	0.00966

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PTK2	-22858.5
LAMA4	-22376.5
LAMA2	-22129.5
MET	-21999.5
LAMB1	-21859.5
ITGA2	-19383.5
LAMC1	-18518.5
LAMA1	-17957.5
LAMC2	-16536.5
LAMA3	-16507.5
ITGA3	-16446.5
LAMB3	-12960.5
ITGB1	-12276.5
LAMC3	-9982.5
SRC	-8349.5
LAMB2	-8100.5
HGF	-7620.5
LAMA5	-4548.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PTK2	-22858.5
LAMA4	-22376.5
LAMA2	-22129.5
MET	-21999.5
LAMB1	-21859.5
ITGA2	-19383.5
LAMC1	-18518.5
LAMA1	-17957.5
LAMC2	-16536.5
LAMA3	-16507.5
ITGA3	-16446.5
LAMB3	-12960.5
ITGB1	-12276.5
LAMC3	-9982.5
SRC	-8349.5
LAMB2	-8100.5
HGF	-7620.5
LAMA5	-4548.5

---

CRMPs in Sema3A signaling

CRMPs in Sema3A signaling

	150
set	CRMPs in Sema3A signaling
setSize	15
pANOVA	0.00315
s.dist	-0.44
p.adjustANOVA	0.0212

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FYN	-22583.5
NRP1	-22467.5
PLXNA4	-22093.5
PLXNA2	-21764.5
DPYSL2	-21558.5
SEMA3A	-20560.5
DPYSL3	-19504.5
GSK3B	-19338.5
PLXNA1	-17310.5
DPYSL5	-15071.5
CDK5R1	-11552.5
FES	-10813.5
CRMP1	-4132.5
DPYSL4	-3868.5
CDK5	-901.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FYN	-22583.5
NRP1	-22467.5
PLXNA4	-22093.5
PLXNA2	-21764.5
DPYSL2	-21558.5
SEMA3A	-20560.5
DPYSL3	-19504.5
GSK3B	-19338.5
PLXNA1	-17310.5
DPYSL5	-15071.5
CDK5R1	-11552.5
FES	-10813.5
CRMP1	-4132.5
DPYSL4	-3868.5
CDK5	-901.5

---

Biotin transport and metabolism

Biotin transport and metabolism

	128
set	Biotin transport and metabolism
setSize	10
pANOVA	0.0162
s.dist	-0.439
p.adjustANOVA	0.0716

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PCCA	-22824.5
ACACB	-21892.5
MCCC1	-21624.5
HLCS	-21573.5
PCCB	-21438.5
ACACA	-20324.5
MCCC2	-12217.5
PC	-9651.5
BTD	-2338.5
SLC5A6	-1644.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PCCA	-22824.5
ACACB	-21892.5
MCCC1	-21624.5
HLCS	-21573.5
PCCB	-21438.5
ACACA	-20324.5
MCCC2	-12217.5
PC	-9651.5
BTD	-2338.5
SLC5A6	-1644.5

---

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

	1334
set	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
setSize	24
pANOVA	0.000199
s.dist	-0.439
p.adjustANOVA	0.00212

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCOA2	-22661.5
AKR1C2	-22459.5
NCOA1	-22042.5
AKR1C4	-21179.5
AKR1C3	-21112.5
SCP2	-20607.5
AKR1D1	-20446.5
CYP7B1	-20172.5
HSD17B4	-19702.5
SLC27A2	-18741.5
AKR1C1	-18478.5
PTGIS	-18422.5
BAAT	-18141.5
ABCB11	-16718.5
NR1H4	-15969.5
SLC27A5	-13844.5
CYP7A1	-11902.5
AMACR	-11090.5
CYP8B1	-10019.5
ACOT8	-8841.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCOA2	-22661.5
AKR1C2	-22459.5
NCOA1	-22042.5
AKR1C4	-21179.5
AKR1C3	-21112.5
SCP2	-20607.5
AKR1D1	-20446.5
CYP7B1	-20172.5
HSD17B4	-19702.5
SLC27A2	-18741.5
AKR1C1	-18478.5
PTGIS	-18422.5
BAAT	-18141.5
ABCB11	-16718.5
NR1H4	-15969.5
SLC27A5	-13844.5
CYP7A1	-11902.5
AMACR	-11090.5
CYP8B1	-10019.5
ACOT8	-8841.5
CYP27A1	-6710.5
ACOX2	-6276.5
RXRA	-4378.5
HSD3B7	-3171.5

---

Interleukin-6 signaling

Interleukin-6 signaling

	636
set	Interleukin-6 signaling
setSize	11
pANOVA	0.0121
s.dist	-0.437
p.adjustANOVA	0.0582

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAT1	-20847.5
SOCS3	-20723.5
JAK1	-19106.5
JAK2	-18853.5
PTPN11	-16732.5
TYK2	-16714.5
IL6ST	-15240.5
IL6R	-13600.5
STAT3	-11462.5
CBL	-10460.5
IL6	-7009.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAT1	-20847.5
SOCS3	-20723.5
JAK1	-19106.5
JAK2	-18853.5
PTPN11	-16732.5
TYK2	-16714.5
IL6ST	-15240.5
IL6R	-13600.5
STAT3	-11462.5
CBL	-10460.5
IL6	-7009.5

---

Nitric oxide stimulates guanylate cyclase

Nitric oxide stimulates guanylate cyclase

	817
set	Nitric oxide stimulates guanylate cyclase
setSize	22
pANOVA	0.000395
s.dist	-0.436
p.adjustANOVA	0.004

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KCNMA1	-22857.5
PDE10A	-22652.5
ITPR1	-22364.5
PDE11A	-22329.5
PDE1A	-22079.5
PRKG1	-22007.5
KCNMB3	-21754.5
PDE5A	-20877.5
KCNMB2	-20121.5
GUCY1A2	-17758.5
NOS3	-17626.5
PRKG2	-15673.5
NOS1	-15347.5
GUCY1A3	-13241.5
NOS2	-12928.5
GUCY1B3	-12710.5
PDE9A	-8546.5
GUCY1B2	-7294.5
PDE1B	-6711.5
PDE2A	-6602.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KCNMA1	-22857.5
PDE10A	-22652.5
ITPR1	-22364.5
PDE11A	-22329.5
PDE1A	-22079.5
PRKG1	-22007.5
KCNMB3	-21754.5
PDE5A	-20877.5
KCNMB2	-20121.5
GUCY1A2	-17758.5
NOS3	-17626.5
PRKG2	-15673.5
NOS1	-15347.5
GUCY1A3	-13241.5
NOS2	-12928.5
GUCY1B3	-12710.5
PDE9A	-8546.5
GUCY1B2	-7294.5
PDE1B	-6711.5
PDE2A	-6602.5
KCNMB4	-6065.5
KCNMB1	-3794.5

---

Collagen chain trimerization

Collagen chain trimerization

	220
set	Collagen chain trimerization
setSize	42
pANOVA	1.07e-06
s.dist	-0.435
p.adjustANOVA	2.92e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL5A2	-22805.5
COL23A1	-22660.5
COL4A2	-22647.5
COL25A1	-22254.5
COL28A1	-21830.5
COL6A6	-21802.5
COL11A2	-21693.5
COL14A1	-21467.5
COL12A1	-21353.5
COL6A3	-21299.5
COL5A1	-21107.5
COL3A1	-20761.5
COL4A1	-20508.5
COL9A1	-20157.5
COL1A2	-19643.5
COL15A1	-19415.5
COL6A5	-19385.5
COL10A1	-19064.5
COL21A1	-17941.5
COL4A3	-17699.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL5A2	-22805.5
COL23A1	-22660.5
COL4A2	-22647.5
COL25A1	-22254.5
COL28A1	-21830.5
COL6A6	-21802.5
COL11A2	-21693.5
COL14A1	-21467.5
COL12A1	-21353.5
COL6A3	-21299.5
COL5A1	-21107.5
COL3A1	-20761.5
COL4A1	-20508.5
COL9A1	-20157.5
COL1A2	-19643.5
COL15A1	-19415.5
COL6A5	-19385.5
COL10A1	-19064.5
COL21A1	-17941.5
COL4A3	-17699.5
COL26A1	-17509.5
COL17A1	-16910.5
COL27A1	-16026.5
COL6A2	-15914.5
COL13A1	-14600.5
COL22A1	-13279.5
COL9A2	-12283.5
COL20A1	-12142.5
COL19A1	-12138.5
COL8A1	-11946.5
COL8A2	-10393.5
COL9A3	-9744.5
COL18A1	-9724.5
COL2A1	-9633.5
COL6A1	-9316.5
COL16A1	-9057.5
COL1A1	-8940.5
COL4A4	-6994.5
COL7A1	-6509.5
COL24A1	-5451.5
COL11A1	-4661.5
COL5A3	-2001.5

---

VEGFR2 mediated vascular permeability

VEGFR2 mediated vascular permeability

	1472
set	VEGFR2 mediated vascular permeability
setSize	26
pANOVA	0.000129
s.dist	-0.434
p.adjustANOVA	0.00149

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AKT3	-22765.5
MAPKAP1	-22738.5
CTNNA1	-22734.5
MTOR	-22450.5
CTNND1	-22230.5
RICTOR	-21854.5
VAV3	-21690.5
CDH5	-19850.5
CAV1	-18999.5
VAV2	-18383.5
NOS3	-17626.5
AKT2	-17549.5
VAV1	-16979.5
RAC1	-15917.5
PDPK1	-15745.5
PAK1	-14690.5
TRIB3	-13197.5
CTNNB1	-13068.5
PRR5	-11403.5
JUP	-10337.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AKT3	-22765.5
MAPKAP1	-22738.5
CTNNA1	-22734.5
MTOR	-22450.5
CTNND1	-22230.5
RICTOR	-21854.5
VAV3	-21690.5
CDH5	-19850.5
CAV1	-18999.5
VAV2	-18383.5
NOS3	-17626.5
AKT2	-17549.5
VAV1	-16979.5
RAC1	-15917.5
PDPK1	-15745.5
PAK1	-14690.5
TRIB3	-13197.5
CTNNB1	-13068.5
PRR5	-11403.5
JUP	-10337.5
HSP90AA1	-8854.5
THEM4	-8648.5
AKT1	-8553.5
PAK2	-8359.5
MLST8	-3959.5
CALM1	-3924.5

---

Synthesis of bile acids and bile salts via 24-hydroxycholesterol

Synthesis of bile acids and bile salts via 24-hydroxycholesterol

	1332
set	Synthesis of bile acids and bile salts via 24-hydroxycholesterol
setSize	14
pANOVA	0.00532
s.dist	-0.43
p.adjustANOVA	0.0321

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AKR1C2	-22459.5
AKR1C4	-21179.5
AKR1C3	-21112.5
AKR1D1	-20446.5
SLC27A2	-18741.5
CYP39A1	-18739.5
AKR1C1	-18478.5
PTGIS	-18422.5
SLC27A5	-13844.5
CYP46A1	-11705.5
AMACR	-11090.5
CYP8B1	-10019.5
CYP27A1	-6710.5
HSD3B7	-3171.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AKR1C2	-22459.5
AKR1C4	-21179.5
AKR1C3	-21112.5
AKR1D1	-20446.5
SLC27A2	-18741.5
CYP39A1	-18739.5
AKR1C1	-18478.5
PTGIS	-18422.5
SLC27A5	-13844.5
CYP46A1	-11705.5
AMACR	-11090.5
CYP8B1	-10019.5
CYP27A1	-6710.5
HSD3B7	-3171.5

---

Mucopolysaccharidoses

Mucopolysaccharidoses

	757
set	Mucopolysaccharidoses
setSize	10
pANOVA	0.0189
s.dist	-0.428
p.adjustANOVA	0.0806

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HGSNAT	-21282.5
GLB1	-20341.5
ARSB	-17974.5
GALNS	-17110.5
GUSB	-16098.5
GNS	-15919.5
IDUA	-14606.5
HYAL1	-14330.5
SGSH	-9345.5
NAGLU	-7154.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HGSNAT	-21282.5
GLB1	-20341.5
ARSB	-17974.5
GALNS	-17110.5
GUSB	-16098.5
GNS	-15919.5
IDUA	-14606.5
HYAL1	-14330.5
SGSH	-9345.5
NAGLU	-7154.5

---

Synthesis of bile acids and bile salts

Synthesis of bile acids and bile salts

	1331
set	Synthesis of bile acids and bile salts
setSize	34
pANOVA	1.55e-05
s.dist	-0.428
p.adjustANOVA	0.000254

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCOA2	-22661.5
AKR1C2	-22459.5
OSBPL3	-22165.5
NCOA1	-22042.5
OSBPL6	-21237.5
AKR1C4	-21179.5
AKR1C3	-21112.5
SCP2	-20607.5
AKR1D1	-20446.5
OSBPL9	-20328.5
CYP7B1	-20172.5
HSD17B4	-19702.5
SLC27A2	-18741.5
CYP39A1	-18739.5
AKR1C1	-18478.5
PTGIS	-18422.5
OSBPL2	-18255.5
BAAT	-18141.5
ABCB11	-16718.5
NR1H4	-15969.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCOA2	-22661.5
AKR1C2	-22459.5
OSBPL3	-22165.5
NCOA1	-22042.5
OSBPL6	-21237.5
AKR1C4	-21179.5
AKR1C3	-21112.5
SCP2	-20607.5
AKR1D1	-20446.5
OSBPL9	-20328.5
CYP7B1	-20172.5
HSD17B4	-19702.5
SLC27A2	-18741.5
CYP39A1	-18739.5
AKR1C1	-18478.5
PTGIS	-18422.5
OSBPL2	-18255.5
BAAT	-18141.5
ABCB11	-16718.5
NR1H4	-15969.5
OSBPL1A	-14500.5
SLC27A5	-13844.5
OSBP	-13062.5
CYP7A1	-11902.5
CYP46A1	-11705.5
AMACR	-11090.5
OSBPL7	-10726.5
CYP8B1	-10019.5
ACOT8	-8841.5
CYP27A1	-6710.5
ACOX2	-6276.5
RXRA	-4378.5
HSD3B7	-3171.5
CH25H	0.5

---

RND1 GTPase cycle

RND1 GTPase cycle

	1041
set	RND1 GTPase cycle
setSize	41
pANOVA	2.74e-06
s.dist	-0.423
p.adjustANOVA	6.55e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DST	-22886.5
PKP4	-22677.5
ALDH3A2	-22100.5
RASAL2	-21919.5
TFRC	-21905.5
FRS3	-21882.5
DLG5	-21790.5
MUC13	-21389.5
RRAS2	-21267.5
PIK3R2	-20729.5
FRS2	-20682.5
DEPDC1B	-20359.5
PLEKHG5	-20028.5
ANKRD26	-19969.5
KIDINS220	-19722.5
GRB7	-19621.5
DSP	-19346.5
FAM135A	-19243.5
CAV1	-18999.5
KIF14	-18309.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DST	-22886.5
PKP4	-22677.5
ALDH3A2	-22100.5
RASAL2	-21919.5
TFRC	-21905.5
FRS3	-21882.5
DLG5	-21790.5
MUC13	-21389.5
RRAS2	-21267.5
PIK3R2	-20729.5
FRS2	-20682.5
DEPDC1B	-20359.5
PLEKHG5	-20028.5
ANKRD26	-19969.5
KIDINS220	-19722.5
GRB7	-19621.5
DSP	-19346.5
FAM135A	-19243.5
CAV1	-18999.5
KIF14	-18309.5
STIP1	-18079.5
EPHA2	-17755.5
VANGL1	-17599.5
FAM83B	-17484.5
PLXNA1	-17310.5
FLOT2	-16464.5
ARHGAP35	-16084.5
CCDC88A	-14746.5
RND1	-13551.5
PIK3R1	-12629.5
CPD	-11478.5
WDR6	-10519.5
TMEM59	-9669.5
VANGL2	-7055.5
PTPN13	-5016.5
LEMD3	-4420.5
EPSTI1	-3275.5
TXNL1	-3073.5
STMN2	-1595.5
ARHGAP5	1013.5
UBXN11	2742.5

---

Adenylate cyclase inhibitory pathway

Adenylate cyclase inhibitory pathway

	65
set	Adenylate cyclase inhibitory pathway
setSize	14
pANOVA	0.00651
s.dist	-0.42
p.adjustANOVA	0.0371

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADCY2	-21801.5
GNAT3	-21051.5
ADCY1	-20495.5
GNAL	-19877.5
ADCY3	-19801.5
ADCY8	-19735.5
ADCY5	-17837.5
GNAI1	-17465.5
ADCY7	-15087.5
ADCY9	-12308.5
ADCY4	-11594.5
GNAI2	-5940.5
GNAI3	-5857.5
ADCY6	-5400.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADCY2	-21801.5
GNAT3	-21051.5
ADCY1	-20495.5
GNAL	-19877.5
ADCY3	-19801.5
ADCY8	-19735.5
ADCY5	-17837.5
GNAI1	-17465.5
ADCY7	-15087.5
ADCY9	-12308.5
ADCY4	-11594.5
GNAI2	-5940.5
GNAI3	-5857.5
ADCY6	-5400.5

---

Defective B3GALTL causes PpS

Defective B3GALTL causes PpS

	278
set	Defective B3GALTL causes PpS
setSize	36
pANOVA	1.4e-05
s.dist	-0.418
p.adjustANOVA	0.000236

Top enriched genes

Top 20 genes

GeneID	Gene Rank
THSD4	-22767.5
ADAMTSL1	-22701.5
ADAMTSL3	-22594.5
SPON1	-22572.5
ADAMTS18	-21907.5
THSD7B	-21769.5
ADAMTS3	-21708.5
THSD7A	-21600.5
ADAMTS2	-20812.5
THBS1	-20435.5
ADAMTS9	-20259.5
SEMA5A	-20212.5
ADAMTS7	-20052.5
ADAMTS12	-19828.5
ADAMTS16	-19703.5
ADAMTS13	-18142.5
ADAMTS17	-17979.5
ADAMTSL2	-17620.5
ADAMTS15	-16941.5
ADAMTS20	-15113.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
THSD4	-22767.5
ADAMTSL1	-22701.5
ADAMTSL3	-22594.5
SPON1	-22572.5
ADAMTS18	-21907.5
THSD7B	-21769.5
ADAMTS3	-21708.5
THSD7A	-21600.5
ADAMTS2	-20812.5
THBS1	-20435.5
ADAMTS9	-20259.5
SEMA5A	-20212.5
ADAMTS7	-20052.5
ADAMTS12	-19828.5
ADAMTS16	-19703.5
ADAMTS13	-18142.5
ADAMTS17	-17979.5
ADAMTSL2	-17620.5
ADAMTS15	-16941.5
ADAMTS20	-15113.5
ADAMTS5	-15052.5
THBS2	-13825.5
SEMA5B	-12543.5
B3GLCT	-12509.5
ADAMTSL5	-12321.5
ADAMTS19	-11839.5
ADAMTS14	-11797.5
ADAMTS10	-10849.5
SPON2	-9969.5
ADAMTS6	-9265.5
ADAMTS8	-8302.5
ADAMTS4	-7182.5
ADAMTSL4	-6953.5
SBSPON	-6775.5
THSD1	1880.5
ADAMTS1	2104.5

---

Non-integrin membrane-ECM interactions

Non-integrin membrane-ECM interactions

	819
set	Non-integrin membrane-ECM interactions
setSize	40
pANOVA	4.81e-06
s.dist	-0.418
p.adjustANOVA	0.000102

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKCA	-22831.5
NRXN1	-22781.5
DDR2	-22763.5
SDC2	-22650.5
DAG1	-22378.5
LAMA4	-22376.5
LAMA2	-22129.5
LAMB1	-21859.5
NTN4	-21735.5
THBS1	-20435.5
HSPG2	-20428.5
TTR	-20260.5
ITGB5	-20170.5
ITGA2	-19383.5
LAMC1	-18518.5
LAMA1	-17957.5
FGF2	-17828.5
ITGA6	-17350.5
TNC	-17108.5
AGRN	-16966.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKCA	-22831.5
NRXN1	-22781.5
DDR2	-22763.5
SDC2	-22650.5
DAG1	-22378.5
LAMA4	-22376.5
LAMA2	-22129.5
LAMB1	-21859.5
NTN4	-21735.5
THBS1	-20435.5
HSPG2	-20428.5
TTR	-20260.5
ITGB5	-20170.5
ITGA2	-19383.5
LAMC1	-18518.5
LAMA1	-17957.5
FGF2	-17828.5
ITGA6	-17350.5
TNC	-17108.5
AGRN	-16966.5
LAMC2	-16536.5
LAMA3	-16507.5
ITGB3	-16259.5
PDGFA	-16147.5
DDR1	-16099.5
SDC3	-15262.5
ITGAV	-14583.5
LAMB3	-12960.5
ITGB1	-12276.5
LAMC3	-9982.5
ITGB4	-9404.5
PDGFB	-8904.5
ACTN1	-8435.5
LAMB2	-8100.5
SDC1	-7540.5
TRAPPC4	-4838.5
LAMA5	-4548.5
SDC4	-3699.5
VTN	-3134.5
TGFB1	2379.5

---

DAG and IP3 signaling

DAG and IP3 signaling

	255
set	DAG and IP3 signaling
setSize	39
pANOVA	7.87e-06
s.dist	-0.413
p.adjustANOVA	0.000145

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ITPR2	-22838.5
PRKCA	-22831.5
PDE1C	-22797.5
PRKCE	-22768.5
ITPR1	-22364.5
PDE1A	-22079.5
ADCY2	-21801.5
CAMK4	-21023.5
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY3	-19801.5
ADCY8	-19735.5
NBEA	-19430.5
CAMK2D	-19386.5
PRKAR1A	-18982.5
ADCY5	-17837.5
PRKACG	-17006.5
CAMKK2	-16826.5
CAMK2A	-16651.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ITPR2	-22838.5
PRKCA	-22831.5
PDE1C	-22797.5
PRKCE	-22768.5
ITPR1	-22364.5
PDE1A	-22079.5
ADCY2	-21801.5
CAMK4	-21023.5
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY3	-19801.5
ADCY8	-19735.5
NBEA	-19430.5
CAMK2D	-19386.5
PRKAR1A	-18982.5
ADCY5	-17837.5
PRKACG	-17006.5
CAMKK2	-16826.5
CAMK2A	-16651.5
AHCYL1	-16493.5
CREB1	-16444.5
CAMK2B	-16109.5
PRKAR2A	-15395.5
PRKAR2B	-15391.5
ADCY7	-15087.5
PRKCD	-14131.5
PLCG1	-13938.5
ADCY9	-12308.5
KPNA2	-11825.5
ADCY4	-11594.5
CAMK2G	-9386.5
PDE1B	-6711.5
ADCY6	-5400.5
PRKCG	-4694.5
CALM1	-3924.5
ITPR3	-3237.5
CAMKK1	1638.5
PRKACA	2274.5

---

Heme biosynthesis

Heme biosynthesis

	557
set	Heme biosynthesis
setSize	13
pANOVA	0.00988
s.dist	-0.413
p.adjustANOVA	0.0503

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ALAS1	-21479.5
ALB	-21096.5
FLVCR1	-20331.5
ABCG2	-20307.5
CPOX	-19397.5
COX10	-18641.5
UROS	-16575.5
HMBS	-14780.5
ALAD	-13819.5
COX15	-9685.5
UROD	-9103.5
PPOX	-8807.5
FECH	-3785.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ALAS1	-21479.5
ALB	-21096.5
FLVCR1	-20331.5
ABCG2	-20307.5
CPOX	-19397.5
COX10	-18641.5
UROS	-16575.5
HMBS	-14780.5
ALAD	-13819.5
COX15	-9685.5
UROD	-9103.5
PPOX	-8807.5
FECH	-3785.5

---

RORA activates gene expression

RORA activates gene expression

	1044
set	RORA activates gene expression
setSize	17
pANOVA	0.0032
s.dist	-0.413
p.adjustANOVA	0.0212

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RORA	-22876.5
NCOA2	-22661.5
NCOA1	-22042.5
CREBBP	-21720.5
CPT1A	-21580.5
CHD9	-20423.5
SMARCD3	-19187.5
TBL1XR1	-17578.5
CARM1	-17023.5
EP300	-16400.5
MED1	-14655.5
SREBF1	-14048.5
NCOA6	-11329.5
PPARA	-10069.5
RXRA	-4378.5
HELZ2	-1345.5
TGS1	-1279.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RORA	-22876.5
NCOA2	-22661.5
NCOA1	-22042.5
CREBBP	-21720.5
CPT1A	-21580.5
CHD9	-20423.5
SMARCD3	-19187.5
TBL1XR1	-17578.5
CARM1	-17023.5
EP300	-16400.5
MED1	-14655.5
SREBF1	-14048.5
NCOA6	-11329.5
PPARA	-10069.5
RXRA	-4378.5
HELZ2	-1345.5
TGS1	-1279.5

---

PKA-mediated phosphorylation of CREB

PKA-mediated phosphorylation of CREB

	880
set	PKA-mediated phosphorylation of CREB
setSize	19
pANOVA	0.00186
s.dist	-0.412
p.adjustANOVA	0.0137

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADCY2	-21801.5
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY3	-19801.5
ADCY8	-19735.5
NBEA	-19430.5
PRKAR1A	-18982.5
ADCY5	-17837.5
PRKACG	-17006.5
CREB1	-16444.5
PRKAR2A	-15395.5
PRKAR2B	-15391.5
ADCY7	-15087.5
ADCY9	-12308.5
ADCY4	-11594.5
ADCY6	-5400.5
CALM1	-3924.5
PRKACA	2274.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADCY2	-21801.5
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY3	-19801.5
ADCY8	-19735.5
NBEA	-19430.5
PRKAR1A	-18982.5
ADCY5	-17837.5
PRKACG	-17006.5
CREB1	-16444.5
PRKAR2A	-15395.5
PRKAR2B	-15391.5
ADCY7	-15087.5
ADCY9	-12308.5
ADCY4	-11594.5
ADCY6	-5400.5
CALM1	-3924.5
PRKACA	2274.5

---

Bile acid and bile salt metabolism

Bile acid and bile salt metabolism

	122
set	Bile acid and bile salt metabolism
setSize	45
pANOVA	1.83e-06
s.dist	-0.411
p.adjustANOVA	4.47e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCOA2	-22661.5
AKR1C2	-22459.5
OSBPL3	-22165.5
NCOA1	-22042.5
OSBPL6	-21237.5
AKR1C4	-21179.5
AKR1C3	-21112.5
ALB	-21096.5
SLCO1A2	-20886.5
SLCO1B3	-20818.5
SCP2	-20607.5
AKR1D1	-20446.5
OSBPL9	-20328.5
CYP7B1	-20172.5
FABP6	-20040.5
HSD17B4	-19702.5
SLC27A2	-18741.5
CYP39A1	-18739.5
AKR1C1	-18478.5
PTGIS	-18422.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCOA2	-22661.5
AKR1C2	-22459.5
OSBPL3	-22165.5
NCOA1	-22042.5
OSBPL6	-21237.5
AKR1C4	-21179.5
AKR1C3	-21112.5
ALB	-21096.5
SLCO1A2	-20886.5
SLCO1B3	-20818.5
SCP2	-20607.5
AKR1D1	-20446.5
OSBPL9	-20328.5
CYP7B1	-20172.5
FABP6	-20040.5
HSD17B4	-19702.5
SLC27A2	-18741.5
CYP39A1	-18739.5
AKR1C1	-18478.5
PTGIS	-18422.5
OSBPL2	-18255.5
BAAT	-18141.5
SLC51A	-16993.5
ABCB11	-16718.5
SLC10A1	-16656.5
NR1H4	-15969.5
SLC10A2	-15823.5
OSBPL1A	-14500.5
SLC27A5	-13844.5
STARD5	-13249.5
OSBP	-13062.5
CYP7A1	-11902.5
CYP46A1	-11705.5
AMACR	-11090.5
OSBPL7	-10726.5
CYP8B1	-10019.5
ACOT8	-8841.5
ABCC3	-8537.5
CYP27A1	-6710.5
ACOX2	-6276.5
SLC51B	-5142.5
RXRA	-4378.5
HSD3B7	-3171.5
CH25H	0.5
SLCO1B1	0.5

---

RHOU GTPase cycle

RHOU GTPase cycle

	1011
set	RHOU GTPase cycle
setSize	37
pANOVA	1.61e-05
s.dist	-0.41
p.adjustANOVA	0.000262

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DST	-22886.5
ARHGEF7	-22679.5
SPTBN1	-22297.5
MYO6	-22147.5
ITSN2	-21867.5
WWP2	-21816.5
DLG5	-21790.5
ARHGAP31	-20992.5
PIK3R2	-20729.5
IQGAP1	-20644.5
DEPDC1B	-20359.5
PEAK1	-20182.5
NCK2	-19780.5
SRGAP2	-19629.5
GIT2	-19544.5
NCK1	-19529.5
HGS	-18227.5
EPHA2	-17755.5
VANGL1	-17599.5
STAM	-17338.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DST	-22886.5
ARHGEF7	-22679.5
SPTBN1	-22297.5
MYO6	-22147.5
ITSN2	-21867.5
WWP2	-21816.5
DLG5	-21790.5
ARHGAP31	-20992.5
PIK3R2	-20729.5
IQGAP1	-20644.5
DEPDC1B	-20359.5
PEAK1	-20182.5
NCK2	-19780.5
SRGAP2	-19629.5
GIT2	-19544.5
NCK1	-19529.5
HGS	-18227.5
EPHA2	-17755.5
VANGL1	-17599.5
STAM	-17338.5
STAM2	-16971.5
CLTC	-15662.5
PAK4	-14718.5
PAK1	-14690.5
PIK3R1	-12629.5
PTK2B	-12236.5
WDR6	-10519.5
PARD6A	-9186.0
GRB2	-8843.5
PAK2	-8359.5
SRC	-8349.5
RHOU	-8174.5
CDC42	-3639.5
TXNL1	-3073.5
SPTAN1	-2501.5
GIT1	-2038.5
ARHGAP30	-1646.5

---

Recycling of bile acids and salts

Recycling of bile acids and salts

	1065
set	Recycling of bile acids and salts
setSize	18
pANOVA	0.00263
s.dist	-0.409
p.adjustANOVA	0.0187

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCOA2	-22661.5
NCOA1	-22042.5
ALB	-21096.5
SLCO1A2	-20886.5
SLCO1B3	-20818.5
FABP6	-20040.5
BAAT	-18141.5
SLC51A	-16993.5
ABCB11	-16718.5
SLC10A1	-16656.5
NR1H4	-15969.5
SLC10A2	-15823.5
SLC27A5	-13844.5
STARD5	-13249.5
ABCC3	-8537.5
SLC51B	-5142.5
RXRA	-4378.5
SLCO1B1	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCOA2	-22661.5
NCOA1	-22042.5
ALB	-21096.5
SLCO1A2	-20886.5
SLCO1B3	-20818.5
FABP6	-20040.5
BAAT	-18141.5
SLC51A	-16993.5
ABCB11	-16718.5
SLC10A1	-16656.5
NR1H4	-15969.5
SLC10A2	-15823.5
SLC27A5	-13844.5
STARD5	-13249.5
ABCC3	-8537.5
SLC51B	-5142.5
RXRA	-4378.5
SLCO1B1	0.5

---

PKA activation

PKA activation

	878
set	PKA activation
setSize	18
pANOVA	0.00279
s.dist	-0.407
p.adjustANOVA	0.0196

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADCY2	-21801.5
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY3	-19801.5
ADCY8	-19735.5
NBEA	-19430.5
PRKAR1A	-18982.5
ADCY5	-17837.5
PRKACG	-17006.5
PRKAR2A	-15395.5
PRKAR2B	-15391.5
ADCY7	-15087.5
ADCY9	-12308.5
ADCY4	-11594.5
ADCY6	-5400.5
CALM1	-3924.5
PRKACA	2274.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADCY2	-21801.5
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY3	-19801.5
ADCY8	-19735.5
NBEA	-19430.5
PRKAR1A	-18982.5
ADCY5	-17837.5
PRKACG	-17006.5
PRKAR2A	-15395.5
PRKAR2B	-15391.5
ADCY7	-15087.5
ADCY9	-12308.5
ADCY4	-11594.5
ADCY6	-5400.5
CALM1	-3924.5
PRKACA	2274.5

---

Laminin interactions

Laminin interactions

	665
set	Laminin interactions
setSize	23
pANOVA	0.000818
s.dist	-0.403
p.adjustANOVA	0.00718

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LAMA4	-22376.5
LAMA2	-22129.5
LAMB1	-21859.5
HSPG2	-20428.5
ITGA2	-19383.5
LAMC1	-18518.5
LAMA1	-17957.5
ITGA6	-17350.5
LAMC2	-16536.5
LAMA3	-16507.5
ITGA3	-16446.5
NID1	-15713.5
ITGAV	-14583.5
NID2	-14501.5
ITGA7	-13873.5
LAMB3	-12960.5
ITGB1	-12276.5
ITGA1	-11696.5
LAMC3	-9982.5
COL18A1	-9724.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LAMA4	-22376.5
LAMA2	-22129.5
LAMB1	-21859.5
HSPG2	-20428.5
ITGA2	-19383.5
LAMC1	-18518.5
LAMA1	-17957.5
ITGA6	-17350.5
LAMC2	-16536.5
LAMA3	-16507.5
ITGA3	-16446.5
NID1	-15713.5
ITGAV	-14583.5
NID2	-14501.5
ITGA7	-13873.5
LAMB3	-12960.5
ITGB1	-12276.5
ITGA1	-11696.5
LAMC3	-9982.5
COL18A1	-9724.5
ITGB4	-9404.5
LAMB2	-8100.5
LAMA5	-4548.5

---

O-glycosylation of TSR domain-containing proteins

O-glycosylation of TSR domain-containing proteins

	842
set	O-glycosylation of TSR domain-containing proteins
setSize	37
pANOVA	2.42e-05
s.dist	-0.401
p.adjustANOVA	0.000358

Top enriched genes

Top 20 genes

GeneID	Gene Rank
THSD4	-22767.5
ADAMTSL1	-22701.5
ADAMTSL3	-22594.5
SPON1	-22572.5
ADAMTS18	-21907.5
THSD7B	-21769.5
ADAMTS3	-21708.5
THSD7A	-21600.5
ADAMTS2	-20812.5
THBS1	-20435.5
ADAMTS9	-20259.5
SEMA5A	-20212.5
ADAMTS7	-20052.5
ADAMTS12	-19828.5
ADAMTS16	-19703.5
ADAMTS13	-18142.5
ADAMTS17	-17979.5
ADAMTSL2	-17620.5
ADAMTS15	-16941.5
ADAMTS20	-15113.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
THSD4	-22767.5
ADAMTSL1	-22701.5
ADAMTSL3	-22594.5
SPON1	-22572.5
ADAMTS18	-21907.5
THSD7B	-21769.5
ADAMTS3	-21708.5
THSD7A	-21600.5
ADAMTS2	-20812.5
THBS1	-20435.5
ADAMTS9	-20259.5
SEMA5A	-20212.5
ADAMTS7	-20052.5
ADAMTS12	-19828.5
ADAMTS16	-19703.5
ADAMTS13	-18142.5
ADAMTS17	-17979.5
ADAMTSL2	-17620.5
ADAMTS15	-16941.5
ADAMTS20	-15113.5
ADAMTS5	-15052.5
THBS2	-13825.5
SEMA5B	-12543.5
B3GLCT	-12509.5
ADAMTSL5	-12321.5
ADAMTS19	-11839.5
ADAMTS14	-11797.5
ADAMTS10	-10849.5
SPON2	-9969.5
ADAMTS6	-9265.5
ADAMTS8	-8302.5
ADAMTS4	-7182.5
POFUT2	-6987.5
ADAMTSL4	-6953.5
SBSPON	-6775.5
THSD1	1880.5
ADAMTS1	2104.5

---

CREB1 phosphorylation through the activation of Adenylate Cyclase

CREB1 phosphorylation through the activation of Adenylate Cyclase

	149
set	CREB1 phosphorylation through the activation of Adenylate Cyclase
setSize	11
pANOVA	0.0214
s.dist	-0.401
p.adjustANOVA	0.0878

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY8	-19735.5
PRKAR1A	-18982.5
PRKACG	-17006.5
CREB1	-16444.5
PRKAR2A	-15395.5
PRKAR2B	-15391.5
CALM1	-3924.5
PRKACA	2274.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY8	-19735.5
PRKAR1A	-18982.5
PRKACG	-17006.5
CREB1	-16444.5
PRKAR2A	-15395.5
PRKAR2B	-15391.5
CALM1	-3924.5
PRKACA	2274.5

---

Collagen biosynthesis and modifying enzymes

Collagen biosynthesis and modifying enzymes

	219
set	Collagen biosynthesis and modifying enzymes
setSize	65
pANOVA	2.77e-08
s.dist	-0.398
p.adjustANOVA	1.28e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL5A2	-22805.5
COL23A1	-22660.5
COL4A2	-22647.5
P3H2	-22526.5
PLOD2	-22315.5
COL25A1	-22254.5
COL28A1	-21830.5
COL6A6	-21802.5
ADAMTS3	-21708.5
COL11A2	-21693.5
COL14A1	-21467.5
COL12A1	-21353.5
COL6A3	-21299.5
COLGALT2	-21138.5
COL5A1	-21107.5
ADAMTS2	-20812.5
COL3A1	-20761.5
P4HA1	-20586.5
COL4A1	-20508.5
COL9A1	-20157.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL5A2	-22805.5
COL23A1	-22660.5
COL4A2	-22647.5
P3H2	-22526.5
PLOD2	-22315.5
COL25A1	-22254.5
COL28A1	-21830.5
COL6A6	-21802.5
ADAMTS3	-21708.5
COL11A2	-21693.5
COL14A1	-21467.5
COL12A1	-21353.5
COL6A3	-21299.5
COLGALT2	-21138.5
COL5A1	-21107.5
ADAMTS2	-20812.5
COL3A1	-20761.5
P4HA1	-20586.5
COL4A1	-20508.5
COL9A1	-20157.5
COL1A2	-19643.5
COL15A1	-19415.5
COL6A5	-19385.5
COL10A1	-19064.5
COL21A1	-17941.5
PLOD1	-17769.5
COL4A3	-17699.5
COL26A1	-17509.5
COL17A1	-16910.5
P4HA3	-16856.5
BMP1	-16033.5
COL27A1	-16026.5
COL6A2	-15914.5
PCOLCE2	-15439.5
SERPINH1	-14985.5
COL13A1	-14600.5
P4HA2	-14564.5
COL22A1	-13279.5
COL9A2	-12283.5
COL20A1	-12142.5
COL19A1	-12138.5
COL8A1	-11946.5
ADAMTS14	-11797.5
PCOLCE	-11683.5
P3H3	-11496.5
TLL1	-11304.5
TLL2	-10695.5
COL8A2	-10393.5
P4HB	-10207.5
COLGALT1	-9852.5
COL9A3	-9744.5
COL18A1	-9724.5
COL2A1	-9633.5
PLOD3	-9549.5
COL6A1	-9316.5
COL16A1	-9057.5
COL1A1	-8940.5
COL4A4	-6994.5
COL7A1	-6509.5
COL24A1	-5451.5
PPIB	-5003.5
COL11A1	-4661.5
CRTAP	-4483.5
P3H1	-4125.5
COL5A3	-2001.5

---

Signaling by Leptin

Signaling by Leptin

	1255
set	Signaling by Leptin
setSize	11
pANOVA	0.0238
s.dist	-0.393
p.adjustANOVA	0.0922

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LEP	-21281.5
SOCS3	-20723.5
LEPR	-20076.5
JAK2	-18853.5
IRS1	-17687.5
STAT5B	-16957.5
PTPN11	-16732.5
IRS2	-14170.5
STAT3	-11462.5
STAT5A	-4170.5
SH2B1	-2421.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LEP	-21281.5
SOCS3	-20723.5
LEPR	-20076.5
JAK2	-18853.5
IRS1	-17687.5
STAT5B	-16957.5
PTPN11	-16732.5
IRS2	-14170.5
STAT3	-11462.5
STAT5A	-4170.5
SH2B1	-2421.5

---

Bicarbonate transporters

Bicarbonate transporters

	121
set	Bicarbonate transporters
setSize	10
pANOVA	0.0322
s.dist	-0.391
p.adjustANOVA	0.116

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC4A5	-22343.5
SLC4A4	-21684.5
AHCYL2	-21111.5
SLC4A8	-19985.5
SLC4A10	-18249.5
SLC4A3	-15268.5
SLC4A7	-15148.5
SLC4A1	-11175.5
SLC4A9	-2635.5
SLC4A2	-1666.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC4A5	-22343.5
SLC4A4	-21684.5
AHCYL2	-21111.5
SLC4A8	-19985.5
SLC4A10	-18249.5
SLC4A3	-15268.5
SLC4A7	-15148.5
SLC4A1	-11175.5
SLC4A9	-2635.5
SLC4A2	-1666.5

---

Ca-dependent events

Ca-dependent events

	158
set	Ca-dependent events
setSize	35
pANOVA	6.21e-05
s.dist	-0.391
p.adjustANOVA	0.000786

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKCA	-22831.5
PDE1C	-22797.5
PDE1A	-22079.5
ADCY2	-21801.5
PLA2G4A	-21670.5
CAMK4	-21023.5
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY3	-19801.5
ADCY8	-19735.5
NBEA	-19430.5
CAMK2D	-19386.5
PRKAR1A	-18982.5
ADCY5	-17837.5
PRKACG	-17006.5
CAMKK2	-16826.5
CAMK2A	-16651.5
CREB1	-16444.5
CAMK2B	-16109.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKCA	-22831.5
PDE1C	-22797.5
PDE1A	-22079.5
ADCY2	-21801.5
PLA2G4A	-21670.5
CAMK4	-21023.5
PRKAR1B	-20654.5
ADCY1	-20495.5
PRKACB	-19821.5
ADCY3	-19801.5
ADCY8	-19735.5
NBEA	-19430.5
CAMK2D	-19386.5
PRKAR1A	-18982.5
ADCY5	-17837.5
PRKACG	-17006.5
CAMKK2	-16826.5
CAMK2A	-16651.5
CREB1	-16444.5
CAMK2B	-16109.5
PRKAR2A	-15395.5
PRKAR2B	-15391.5
ADCY7	-15087.5
PRKCD	-14131.5
ADCY9	-12308.5
KPNA2	-11825.5
ADCY4	-11594.5
CAMK2G	-9386.5
MAPK1	-8942.5
PDE1B	-6711.5
ADCY6	-5400.5
PRKCG	-4694.5
CALM1	-3924.5
CAMKK1	1638.5
PRKACA	2274.5

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report