Mitch Report

date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             metric
## SEPT9    -5.324131
## RAD51B    6.608110
## ARHGAP26  5.270977
## ANK3      5.542997
## HOXC4    -4.757554
## LPP       4.858635

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2546
num_genes_in_profile	26148
duplicated_genes_present	0
num_profile_genes_in_sets	10252
num_profile_genes_not_in_sets	15896

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1018
num_genesets_included	1528

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Constitutive Signaling by Overexpressed ERBB2	10	5.91e-04	-0.627	4.16e-03
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	3.01e-05	0.622	3.07e-04
Condensation of Prometaphase Chromosomes	11	8.34e-04	-0.582	5.59e-03
Peptide chain elongation	84	1.02e-18	-0.557	9.15e-17
Viral mRNA Translation	84	7.05e-18	-0.543	4.68e-16
Eukaryotic Translation Elongation	88	1.43e-18	-0.542	1.15e-16
Eukaryotic Translation Termination	87	8.18e-18	-0.533	4.81e-16
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	7.47e-19	-0.526	7.13e-17
SRP-dependent cotranslational protein targeting to membrane	105	1.44e-20	-0.524	1.57e-18
Selenocysteine synthesis	87	4.08e-17	-0.521	2.31e-15
APC/C:Cdc20 mediated degradation of Cyclin B	24	1.38e-05	-0.512	1.54e-04
Formation of a pool of free 40S subunits	95	5.90e-18	-0.512	4.10e-16
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	1.02e-16	-0.508	5.59e-15
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	5.14e-08	0.504	1.08e-06
Hormone ligand-binding receptors	13	1.86e-03	0.498	1.12e-02
RIPK1-mediated regulated necrosis	27	7.52e-06	-0.498	9.34e-05
Regulation of necroptotic cell death	27	7.52e-06	-0.498	9.34e-05
Pexophagy	11	4.25e-03	-0.498	2.19e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	105	1.75e-18	-0.495	1.33e-16
L13a-mediated translational silencing of Ceruloplasmin expression	104	2.93e-18	-0.494	2.13e-16
Activation of the phototransduction cascade	11	4.63e-03	0.493	2.34e-02
RUNX3 regulates p14-ARF	10	7.51e-03	-0.488	3.45e-02
Activation of the TFAP2 (AP-2) family of transcription factors	11	5.14e-03	-0.487	2.50e-02
APC-Cdc20 mediated degradation of Nek2A	26	2.41e-05	-0.478	2.56e-04
Cap-dependent Translation Initiation	112	7.81e-18	-0.470	4.78e-16
Eukaryotic Translation Initiation	112	7.81e-18	-0.470	4.78e-16
Major pathway of rRNA processing in the nucleolus and cytosol	171	1.40e-25	-0.462	2.14e-23
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	9.38e-05	0.460	8.53e-04
rRNA processing in the nucleus and cytosol	180	1.89e-26	-0.459	3.20e-24
Golgi Cisternae Pericentriolar Stack Reorganization	14	2.94e-03	-0.459	1.62e-02
CASP8 activity is inhibited	11	8.54e-03	-0.458	3.81e-02
Dimerization of procaspase-8	11	8.54e-03	-0.458	3.81e-02
Regulation by c-FLIP	11	8.54e-03	-0.458	3.81e-02
SUMOylation of immune response proteins	10	1.27e-02	-0.455	5.17e-02
TICAM1-dependent activation of IRF3/IRF7	12	6.39e-03	-0.454	3.04e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	4.33e-04	-0.454	3.24e-03
Mitochondrial translation termination	87	4.25e-13	-0.449	1.67e-11
Mitochondrial translation elongation	87	6.54e-13	-0.445	2.50e-11
Erythropoietin activates RAS	14	4.00e-03	-0.444	2.08e-02
Interleukin-2 signaling	11	1.08e-02	-0.444	4.61e-02
SARS-CoV-2 modulates host translation machinery	46	1.88e-07	-0.444	3.34e-06
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	32	1.57e-05	-0.441	1.73e-04
SCF(Skp2)-mediated degradation of p27/p21	58	7.47e-09	-0.438	1.87e-07
Mitochondrial translation	93	2.66e-13	-0.438	1.07e-11
Mitochondrial translation initiation	87	2.11e-12	-0.435	7.88e-11
Autodegradation of Cdh1 by Cdh1:APC/C	62	3.16e-09	-0.435	8.61e-08
Reactions specific to the complex N-glycan synthesis pathway	10	1.75e-02	0.434	6.49e-02
KSRP (KHSRP) binds and destabilizes mRNA	17	1.95e-03	-0.434	1.15e-02
rRNA processing	186	2.11e-24	-0.433	2.92e-22
Phosphorylation of the APC/C	20	8.15e-04	-0.432	5.56e-03

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Constitutive Signaling by Overexpressed ERBB2	10	5.91e-04	-0.627000	4.16e-03
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	3.01e-05	0.622000	3.07e-04
Condensation of Prometaphase Chromosomes	11	8.34e-04	-0.582000	5.59e-03
Peptide chain elongation	84	1.02e-18	-0.557000	9.15e-17
Viral mRNA Translation	84	7.05e-18	-0.543000	4.68e-16
Eukaryotic Translation Elongation	88	1.43e-18	-0.542000	1.15e-16
Eukaryotic Translation Termination	87	8.18e-18	-0.533000	4.81e-16
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	7.47e-19	-0.526000	7.13e-17
SRP-dependent cotranslational protein targeting to membrane	105	1.44e-20	-0.524000	1.57e-18
Selenocysteine synthesis	87	4.08e-17	-0.521000	2.31e-15
APC/C:Cdc20 mediated degradation of Cyclin B	24	1.38e-05	-0.512000	1.54e-04
Formation of a pool of free 40S subunits	95	5.90e-18	-0.512000	4.10e-16
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	1.02e-16	-0.508000	5.59e-15
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	5.14e-08	0.504000	1.08e-06
Hormone ligand-binding receptors	13	1.86e-03	0.498000	1.12e-02
RIPK1-mediated regulated necrosis	27	7.52e-06	-0.498000	9.34e-05
Regulation of necroptotic cell death	27	7.52e-06	-0.498000	9.34e-05
Pexophagy	11	4.25e-03	-0.498000	2.19e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	105	1.75e-18	-0.495000	1.33e-16
L13a-mediated translational silencing of Ceruloplasmin expression	104	2.93e-18	-0.494000	2.13e-16
Activation of the phototransduction cascade	11	4.63e-03	0.493000	2.34e-02
RUNX3 regulates p14-ARF	10	7.51e-03	-0.488000	3.45e-02
Activation of the TFAP2 (AP-2) family of transcription factors	11	5.14e-03	-0.487000	2.50e-02
APC-Cdc20 mediated degradation of Nek2A	26	2.41e-05	-0.478000	2.56e-04
Cap-dependent Translation Initiation	112	7.81e-18	-0.470000	4.78e-16
Eukaryotic Translation Initiation	112	7.81e-18	-0.470000	4.78e-16
Major pathway of rRNA processing in the nucleolus and cytosol	171	1.40e-25	-0.462000	2.14e-23
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	9.38e-05	0.460000	8.53e-04
rRNA processing in the nucleus and cytosol	180	1.89e-26	-0.459000	3.20e-24
Golgi Cisternae Pericentriolar Stack Reorganization	14	2.94e-03	-0.459000	1.62e-02
CASP8 activity is inhibited	11	8.54e-03	-0.458000	3.81e-02
Dimerization of procaspase-8	11	8.54e-03	-0.458000	3.81e-02
Regulation by c-FLIP	11	8.54e-03	-0.458000	3.81e-02
SUMOylation of immune response proteins	10	1.27e-02	-0.455000	5.17e-02
TICAM1-dependent activation of IRF3/IRF7	12	6.39e-03	-0.454000	3.04e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	4.33e-04	-0.454000	3.24e-03
Mitochondrial translation termination	87	4.25e-13	-0.449000	1.67e-11
Mitochondrial translation elongation	87	6.54e-13	-0.445000	2.50e-11
Erythropoietin activates RAS	14	4.00e-03	-0.444000	2.08e-02
Interleukin-2 signaling	11	1.08e-02	-0.444000	4.61e-02
SARS-CoV-2 modulates host translation machinery	46	1.88e-07	-0.444000	3.34e-06
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	32	1.57e-05	-0.441000	1.73e-04
SCF(Skp2)-mediated degradation of p27/p21	58	7.47e-09	-0.438000	1.87e-07
Mitochondrial translation	93	2.66e-13	-0.438000	1.07e-11
Mitochondrial translation initiation	87	2.11e-12	-0.435000	7.88e-11
Autodegradation of Cdh1 by Cdh1:APC/C	62	3.16e-09	-0.435000	8.61e-08
Reactions specific to the complex N-glycan synthesis pathway	10	1.75e-02	0.434000	6.49e-02
KSRP (KHSRP) binds and destabilizes mRNA	17	1.95e-03	-0.434000	1.15e-02
rRNA processing	186	2.11e-24	-0.433000	2.92e-22
Phosphorylation of the APC/C	20	8.15e-04	-0.432000	5.56e-03
Prefoldin mediated transfer of substrate to CCT/TriC	27	1.08e-04	-0.430000	9.57e-04
Selenoamino acid metabolism	103	4.35e-14	-0.430000	1.90e-12
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	9.74e-04	-0.426000	6.47e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	2.02e-02	-0.424000	7.16e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	5.43e-10	-0.423000	1.66e-08
Unwinding of DNA	12	1.19e-02	-0.419000	4.86e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	108	6.00e-14	-0.418000	2.48e-12
Nonsense-Mediated Decay (NMD)	108	6.00e-14	-0.418000	2.48e-12
Response of EIF2AK1 (HRI) to heme deficiency	14	6.82e-03	-0.417000	3.19e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	9.51e-03	-0.415000	4.16e-02
Translation	263	4.08e-31	-0.414000	1.04e-28
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	3.92e-07	-0.414000	6.81e-06
Regulation of expression of SLITs and ROBOs	159	3.56e-19	-0.411000	3.63e-17
TICAM1,TRAF6-dependent induction of TAK1 complex	10	2.46e-02	-0.410000	8.35e-02
Formation of the ternary complex, and subsequently, the 43S complex	47	1.32e-06	-0.407000	1.98e-05
Intrinsic Pathway of Fibrin Clot Formation	21	1.25e-03	0.407000	8.01e-03
ATF6 (ATF6-alpha) activates chaperones	11	2.02e-02	-0.404000	7.16e-02
APC/C:Cdc20 mediated degradation of Securin	66	1.31e-08	-0.404000	3.24e-07
APC/C-mediated degradation of cell cycle proteins	86	9.70e-11	-0.403000	3.15e-09
Regulation of mitotic cell cycle	86	9.70e-11	-0.403000	3.15e-09
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	1.69e-09	-0.402000	5.07e-08
APC/C:Cdc20 mediated degradation of mitotic proteins	74	2.65e-09	-0.400000	7.65e-08
ATF6 (ATF6-alpha) activates chaperone genes	10	2.86e-02	-0.400000	9.39e-02
Negative regulation of NOTCH4 signaling	52	7.32e-07	-0.397000	1.17e-05
Synthesis of glycosylphosphatidylinositol (GPI)	17	4.65e-03	-0.396000	2.34e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	6.77e-09	-0.395000	1.72e-07
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	7.27e-07	-0.393000	1.17e-05
SCF-beta-TrCP mediated degradation of Emi1	53	8.12e-07	-0.391000	1.28e-05
Ribosomal scanning and start codon recognition	54	6.74e-07	-0.391000	1.10e-05
Inactivation of APC/C via direct inhibition of the APC/C complex	21	1.95e-03	-0.390000	1.15e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	1.95e-03	-0.390000	1.15e-02
Synthesis of PE	12	1.94e-02	-0.390000	6.99e-02
Ubiquitin-dependent degradation of Cyclin D	50	1.85e-06	-0.390000	2.74e-05
The role of GTSE1 in G2/M progression after G2 checkpoint	58	2.81e-07	-0.390000	4.94e-06
DNA Damage Recognition in GG-NER	36	5.21e-05	-0.389000	4.94e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	1.37e-08	-0.389000	3.28e-07
Influenza Viral RNA Transcription and Replication	129	2.55e-14	-0.388000	1.18e-12
Autodegradation of the E3 ubiquitin ligase COP1	50	2.41e-06	-0.385000	3.44e-05
TP53 Regulates Transcription of Death Receptors and Ligands	12	2.10e-02	-0.385000	7.35e-02
Negative regulation of FLT3	15	9.96e-03	-0.384000	4.31e-02
Regulation of APC/C activators between G1/S and early anaphase	79	4.40e-09	-0.382000	1.14e-07
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	4.85e-06	-0.381000	6.29e-05
Translation initiation complex formation	54	1.28e-06	-0.381000	1.94e-05
WNT ligand biogenesis and trafficking	25	1.00e-03	-0.380000	6.63e-03
CDK-mediated phosphorylation and removal of Cdc6	71	3.12e-08	-0.380000	6.95e-07
Apoptotic factor-mediated response	17	6.72e-03	-0.380000	3.17e-02
Diseases of mitotic cell cycle	37	6.42e-05	-0.379000	5.95e-04
Interaction between L1 and Ankyrins	28	5.45e-04	0.377000	3.93e-03
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	2.36e-06	-0.375000	3.42e-05
p38MAPK events	13	1.96e-02	-0.374000	7.04e-02
mRNA decay by 3’ to 5’ exoribonuclease	16	9.64e-03	-0.374000	4.18e-02
Pyrimidine catabolism	12	2.53e-02	0.373000	8.53e-02
Folding of actin by CCT/TriC	10	4.11e-02	-0.373000	1.23e-01
Formation of tubulin folding intermediates by CCT/TriC	26	1.01e-03	-0.372000	6.68e-03
p75NTR recruits signalling complexes	12	2.57e-02	-0.372000	8.63e-02
Signaling by Leptin	11	3.28e-02	-0.371000	1.05e-01
Asymmetric localization of PCP proteins	62	4.44e-07	-0.370000	7.63e-06
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	55	2.12e-06	-0.369000	3.11e-05
Cellular response to starvation	147	1.25e-14	-0.368000	5.99e-13
Attenuation phase	25	1.44e-03	-0.368000	9.09e-03
ERKs are inactivated	13	2.16e-02	-0.368000	7.49e-02
Other interleukin signaling	24	1.82e-03	-0.368000	1.09e-02
Dectin-1 mediated noncanonical NF-kB signaling	60	1.00e-06	-0.365000	1.55e-05
Calnexin/calreticulin cycle	25	1.59e-03	-0.365000	9.84e-03
Regulation of RUNX3 expression and activity	53	4.38e-06	-0.364000	5.92e-05
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	1.63e-04	-0.363000	1.33e-03
Vpu mediated degradation of CD4	50	1.02e-05	-0.361000	1.18e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	1.02e-05	-0.360000	1.18e-04
p53-Independent DNA Damage Response	50	1.02e-05	-0.360000	1.18e-04
p53-Independent G1/S DNA damage checkpoint	50	1.02e-05	-0.360000	1.18e-04
p53-Dependent G1 DNA Damage Response	64	6.01e-07	-0.360000	9.99e-06
p53-Dependent G1/S DNA damage checkpoint	64	6.01e-07	-0.360000	9.99e-06
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	3.08e-02	-0.360000	9.98e-02
Influenza Infection	148	4.02e-14	-0.360000	1.81e-12
Stabilization of p53	55	4.12e-06	-0.359000	5.62e-05
Translation of Structural Proteins	29	8.22e-04	-0.359000	5.57e-03
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	8.54e-03	-0.358000	3.81e-02
NIK–>noncanonical NF-kB signaling	57	3.08e-06	-0.357000	4.28e-05
rRNA modification in the nucleus and cytosol	55	4.72e-06	-0.357000	6.16e-05
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	2.09e-02	-0.356000	7.33e-02
Caspase activation via Death Receptors in the presence of ligand	16	1.42e-02	-0.354000	5.55e-02
PINK1-PRKN Mediated Mitophagy	21	5.08e-03	-0.353000	2.48e-02
Abacavir ADME	10	5.37e-02	0.352000	1.48e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	21	5.19e-03	-0.352000	2.52e-02
Trafficking of GluR2-containing AMPA receptors	15	1.86e-02	0.351000	6.81e-02
Senescence-Associated Secretory Phenotype (SASP)	53	1.00e-05	-0.350000	1.18e-04
Nitric oxide stimulates guanylate cyclase	22	4.52e-03	0.350000	2.30e-02
G1/S DNA Damage Checkpoints	66	1.02e-06	-0.348000	1.56e-05
Hh mutants are degraded by ERAD	54	9.88e-06	-0.347000	1.18e-04
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	1.37e-02	-0.345000	5.45e-02
Initiation of Nuclear Envelope (NE) Reformation	18	1.13e-02	-0.345000	4.72e-02
Downregulation of TGF-beta receptor signaling	26	2.33e-03	-0.345000	1.33e-02
Assembly of the pre-replicative complex	82	6.80e-08	-0.344000	1.35e-06
Cyclin A:Cdk2-associated events at S phase entry	83	5.91e-08	-0.344000	1.20e-06
Zinc transporters	17	1.42e-02	-0.343000	5.56e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	7.82e-04	-0.343000	5.36e-03
Vif-mediated degradation of APOBEC3G	50	2.70e-05	-0.343000	2.81e-04
Expression and translocation of olfactory receptors	365	2.06e-29	0.342000	3.93e-27
Synthesis of bile acids and bile salts	34	5.53e-04	0.342000	3.96e-03
Olfactory Signaling Pathway	372	1.81e-29	0.339000	3.93e-27
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	1.71e-04	0.339000	1.39e-03
Regulation of mRNA stability by proteins that bind AU-rich elements	87	4.55e-08	-0.339000	9.65e-07
Regulation of ornithine decarboxylase (ODC)	49	4.06e-05	-0.339000	3.95e-04
SUMOylation of transcription factors	20	8.73e-03	-0.339000	3.88e-02
TICAM1, RIP1-mediated IKK complex recruitment	18	1.30e-02	-0.338000	5.25e-02
GLI3 is processed to GLI3R by the proteasome	58	8.43e-06	-0.338000	1.04e-04
Cyclin E associated events during G1/S transition	81	1.45e-07	-0.338000	2.73e-06
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	12	4.34e-02	-0.337000	1.27e-01
UCH proteinases	81	1.74e-07	-0.336000	3.17e-06
Regulation of TP53 Activity through Methylation	18	1.39e-02	-0.335000	5.48e-02
RIP-mediated NFkB activation via ZBP1	16	2.06e-02	-0.334000	7.26e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14	3.04e-02	0.334000	9.89e-02
VLDLR internalisation and degradation	16	2.12e-02	-0.333000	7.39e-02
RHO GTPases activate KTN1	11	5.68e-02	-0.332000	1.55e-01
Negative regulation of MAPK pathway	41	2.46e-04	-0.331000	1.91e-03
p75NTR signals via NF-kB	15	2.71e-02	-0.329000	8.96e-02
DNA Replication Pre-Initiation	97	2.00e-08	-0.329000	4.57e-07
Mitophagy	27	3.07e-03	-0.329000	1.67e-02
Gap junction assembly	18	1.56e-02	0.329000	6.03e-02
Switching of origins to a post-replicative state	90	6.80e-08	-0.329000	1.35e-06
ALK mutants bind TKIs	12	4.90e-02	0.328000	1.41e-01
NF-kB is activated and signals survival	12	4.92e-02	-0.328000	1.41e-01
Metabolism of polyamines	55	2.65e-05	-0.327000	2.77e-04
NRIF signals cell death from the nucleus	16	2.34e-02	-0.327000	8.03e-02
Acyl chain remodelling of PS	21	9.48e-03	0.327000	4.16e-02
Scavenging of heme from plasma	12	4.99e-02	0.327000	1.42e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	4.78e-03	-0.326000	2.39e-02
Degradation of GLI2 by the proteasome	58	1.74e-05	-0.326000	1.89e-04
NGF-stimulated transcription	39	4.28e-04	-0.326000	3.23e-03
Signaling by NOTCH4	79	5.92e-07	-0.325000	9.99e-06
Cross-presentation of soluble exogenous antigens (endosomes)	48	1.02e-04	-0.324000	9.15e-04
Zinc influx into cells by the SLC39 gene family	10	7.67e-02	-0.323000	1.97e-01
Regulation of Apoptosis	51	6.50e-05	-0.323000	5.95e-04
Signaling by ROBO receptors	203	2.03e-15	-0.323000	1.03e-13
Hh mutants abrogate ligand secretion	57	2.85e-05	-0.320000	2.93e-04
Respiratory electron transport	90	1.48e-07	-0.320000	2.76e-06
DCC mediated attractive signaling	14	3.86e-02	0.319000	1.18e-01
Degradation of DVL	55	4.27e-05	-0.319000	4.10e-04
Degradation of AXIN	53	6.03e-05	-0.318000	5.65e-04
Cyclin D associated events in G1	46	1.86e-04	-0.318000	1.47e-03
G1 Phase	46	1.86e-04	-0.318000	1.47e-03
TP53 Regulates Transcription of Cell Cycle Genes	49	1.18e-04	-0.318000	1.01e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	95	9.58e-08	-0.316000	1.85e-06
Defective pyroptosis	11	6.99e-02	-0.315000	1.84e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	2.45e-02	-0.315000	8.33e-02
Cellular response to hypoxia	71	4.46e-06	-0.315000	5.92e-05
HSF1 activation	27	4.65e-03	-0.315000	2.34e-02
cGMP effects	15	3.50e-02	0.314000	1.09e-01
Regulation of RAS by GAPs	66	9.99e-06	-0.314000	1.18e-04
Glycogen storage diseases	14	4.24e-02	-0.313000	1.25e-01
Free fatty acids regulate insulin secretion	10	8.64e-02	0.313000	2.16e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	8.68e-02	-0.313000	2.16e-01
Class I peroxisomal membrane protein import	19	1.83e-02	-0.313000	6.73e-02
Formation of TC-NER Pre-Incision Complex	51	1.12e-04	-0.313000	9.83e-04
Degradation of GLI1 by the proteasome	58	3.81e-05	-0.312000	3.73e-04
Orc1 removal from chromatin	69	7.43e-06	-0.312000	9.34e-05
Nephrin family interactions	21	1.40e-02	0.310000	5.51e-02
Nuclear Events (kinase and transcription factor activation)	60	3.46e-05	-0.309000	3.43e-04
Oncogene Induced Senescence	35	1.56e-03	-0.309000	9.71e-03
Metallothioneins bind metals	11	7.61e-02	-0.309000	1.96e-01
Butyrophilin (BTN) family interactions	12	6.48e-02	0.308000	1.74e-01
Complex I biogenesis	49	2.05e-04	-0.306000	1.61e-03
Diseases associated with N-glycosylation of proteins	19	2.14e-02	-0.305000	7.46e-02
Killing mechanisms	11	8.02e-02	-0.305000	2.04e-01
WNT5:FZD7-mediated leishmania damping	11	8.02e-02	-0.305000	2.04e-01
Glutathione conjugation	37	1.35e-03	-0.304000	8.59e-03
Nuclear events mediated by NFE2L2	76	4.43e-06	-0.304000	5.92e-05
Regulated Necrosis	53	1.32e-04	-0.303000	1.12e-03
PERK regulates gene expression	32	3.02e-03	-0.303000	1.66e-02
RNA Polymerase I Transcription Termination	27	6.75e-03	-0.301000	3.17e-02
Sealing of the nuclear envelope (NE) by ESCRT-III	31	3.73e-03	-0.301000	1.98e-02
SUMOylation of DNA methylation proteins	16	3.89e-02	-0.298000	1.19e-01
The canonical retinoid cycle in rods (twilight vision)	23	1.33e-02	0.298000	5.36e-02
Inactivation of CSF3 (G-CSF) signaling	23	1.35e-02	-0.297000	5.39e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs	68	2.25e-05	-0.297000	2.41e-04
Ketone body metabolism	10	1.04e-01	0.297000	2.42e-01
Transcriptional regulation by RUNX3	93	8.64e-07	-0.295000	1.35e-05
Processing and activation of SUMO	10	1.07e-01	-0.295000	2.46e-01
Regulation of RUNX2 expression and activity	71	1.76e-05	-0.294000	1.89e-04
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	62	6.03e-05	-0.294000	5.65e-04
Neurotoxicity of clostridium toxins	10	1.09e-01	-0.293000	2.49e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	8.46e-03	-0.293000	3.81e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	5.04e-02	-0.292000	1.43e-01
DNA Replication	125	1.73e-08	-0.292000	4.07e-07
MASTL Facilitates Mitotic Progression	10	1.10e-01	-0.291000	2.51e-01
Defective CFTR causes cystic fibrosis	59	1.14e-04	-0.290000	9.85e-04
Beta defensins	32	4.47e-03	0.290000	2.29e-02
Signal regulatory protein family interactions	13	7.04e-02	-0.290000	1.85e-01
ATF4 activates genes in response to endoplasmic reticulum stress	28	8.07e-03	-0.289000	3.67e-02
Synthesis of DNA	118	5.64e-08	-0.289000	1.16e-06
Metabolism of RNA	638	9.46e-36	-0.288000	1.45e-32
Apoptotic cleavage of cell adhesion proteins	11	9.89e-02	0.287000	2.36e-01
Positive epigenetic regulation of rRNA expression	43	1.12e-03	-0.287000	7.23e-03
Sensory Perception	576	3.08e-32	0.287000	1.18e-29
Sensory perception of taste	47	6.75e-04	0.286000	4.69e-03
MET activates PTK2 signaling	18	3.60e-02	0.285000	1.12e-01
G1/S Transition	126	3.14e-08	-0.285000	6.95e-07
Mitotic G1 phase and G1/S transition	144	3.51e-09	-0.285000	9.26e-08
RAF-independent MAPK1/3 activation	22	2.09e-02	-0.284000	7.33e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	4.11e-03	-0.284000	2.13e-02
HDR through MMEJ (alt-NHEJ)	11	1.03e-01	-0.284000	2.41e-01
MET activates RAS signaling	11	1.04e-01	-0.283000	2.42e-01
Cyclin A/B1/B2 associated events during G2/M transition	24	1.64e-02	-0.283000	6.25e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	4.44e-02	-0.282000	1.29e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	4.44e-02	-0.282000	1.29e-01
RNA Polymerase I Promoter Escape	28	1.02e-02	-0.280000	4.39e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	2.30e-02	-0.280000	7.92e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	14	6.98e-02	0.280000	1.84e-01
Diseases of hemostasis	14	6.98e-02	0.280000	1.84e-01
Polo-like kinase mediated events	16	5.26e-02	-0.280000	1.46e-01
Glucuronidation	25	1.56e-02	0.279000	6.02e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	4.01e-02	-0.279000	1.22e-01
PRC2 methylates histones and DNA	13	8.15e-02	-0.279000	2.06e-01
SLBP independent Processing of Histone Pre-mRNAs	10	1.28e-01	-0.278000	2.79e-01
Signalling to RAS	20	3.14e-02	-0.278000	1.01e-01
SARS-CoV-1 Infection	51	6.14e-04	-0.277000	4.30e-03
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	34	5.27e-03	-0.276000	2.55e-02
Transcriptional regulation of granulopoiesis	31	7.92e-03	-0.275000	3.61e-02
Aspirin ADME	44	1.63e-03	0.274000	1.00e-02
mRNA Splicing - Minor Pathway	53	5.63e-04	-0.274000	4.02e-03
TP53 Regulates Transcription of Cell Death Genes	42	2.15e-03	-0.273000	1.25e-02
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	1.35e-01	0.273000	2.90e-01
PI3K events in ERBB2 signaling	16	5.85e-02	0.273000	1.59e-01
S Phase	157	3.50e-09	-0.273000	9.26e-08
FOXO-mediated transcription of cell cycle genes	16	5.90e-02	-0.273000	1.60e-01
Bile acid and bile salt metabolism	45	1.65e-03	0.271000	1.01e-02
RNA Polymerase I Transcription	47	1.31e-03	-0.271000	8.38e-03
B-WICH complex positively regulates rRNA expression	29	1.16e-02	-0.271000	4.78e-02
PCP/CE pathway	90	9.22e-06	-0.270000	1.13e-04
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	16	6.14e-02	-0.270000	1.66e-01
Activated NTRK2 signals through FRS2 and FRS3	11	1.21e-01	-0.270000	2.67e-01
Heme degradation	16	6.18e-02	0.270000	1.67e-01
Regulation of TP53 Activity through Phosphorylation	88	1.23e-05	-0.269000	1.40e-04
Role of LAT2/NTAL/LAB on calcium mobilization	13	9.27e-02	0.269000	2.27e-01
Diseases of programmed cell death	41	2.87e-03	-0.269000	1.59e-02
MAPK6/MAPK4 signaling	89	1.23e-05	-0.268000	1.40e-04
Degradation of beta-catenin by the destruction complex	81	3.10e-05	-0.268000	3.14e-04
Activation of NF-kappaB in B cells	64	2.18e-04	-0.267000	1.70e-03
Mitochondrial iron-sulfur cluster biogenesis	12	1.10e-01	-0.267000	2.50e-01
Mitotic Metaphase and Anaphase	222	7.96e-12	-0.266000	2.83e-10
G2/M Checkpoints	129	1.81e-07	-0.266000	3.25e-06
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	11	1.27e-01	-0.266000	2.77e-01
RNA Polymerase I Promoter Clearance	46	1.81e-03	-0.266000	1.09e-02
Regulation of PTEN gene transcription	59	4.20e-04	-0.265000	3.18e-03
Mitotic Anaphase	221	1.00e-11	-0.265000	3.47e-10
Association of TriC/CCT with target proteins during biosynthesis	38	4.74e-03	-0.265000	2.38e-02
Defensins	40	3.79e-03	0.264000	2.00e-02
RAS processing	19	4.62e-02	-0.264000	1.34e-01
ER Quality Control Compartment (ERQC)	20	4.11e-02	-0.264000	1.23e-01
FLT3 signaling in disease	28	1.60e-02	-0.263000	6.14e-02
BBSome-mediated cargo-targeting to cilium	23	2.93e-02	-0.262000	9.60e-02
Spry regulation of FGF signaling	16	6.98e-02	-0.262000	1.84e-01
Formation of apoptosome	10	1.52e-01	-0.262000	3.17e-01
Regulation of the apoptosome activity	10	1.52e-01	-0.262000	3.17e-01
The citric acid (TCA) cycle and respiratory electron transport	143	7.14e-08	-0.261000	1.40e-06
Regulation of gene expression by Hypoxia-inducible Factor	11	1.37e-01	-0.259000	2.94e-01
Separation of Sister Chromatids	161	1.36e-08	-0.259000	3.28e-07
FGFRL1 modulation of FGFR1 signaling	13	1.06e-01	-0.259000	2.45e-01
Josephin domain DUBs	11	1.37e-01	-0.259000	2.95e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	6.46e-02	-0.259000	1.73e-01
Cytochrome c-mediated apoptotic response	12	1.21e-01	-0.259000	2.67e-01
RUNX3 regulates NOTCH signaling	13	1.07e-01	-0.258000	2.47e-01
Nuclear Envelope (NE) Reassembly	73	1.38e-04	-0.258000	1.15e-03
FOXO-mediated transcription of cell death genes	15	8.38e-02	-0.258000	2.10e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	5.19e-02	-0.257000	1.46e-01
Signaling by CSF3 (G-CSF)	28	1.85e-02	-0.257000	6.79e-02
Glycogen synthesis	15	8.49e-02	-0.257000	2.13e-01
Regulation of pyruvate dehydrogenase (PDH) complex	14	9.86e-02	-0.255000	2.36e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	8.74e-02	-0.255000	2.17e-01
Downstream signaling events of B Cell Receptor (BCR)	78	9.99e-05	-0.255000	8.98e-04
Common Pathway of Fibrin Clot Formation	21	4.33e-02	0.255000	1.27e-01
mRNA Splicing	183	2.79e-09	-0.254000	7.75e-08
Regulation of HSF1-mediated heat shock response	78	1.03e-04	-0.254000	9.16e-04
Transcriptional Regulation by VENTX	41	4.91e-03	-0.254000	2.43e-02
Hedgehog ligand biogenesis	63	5.00e-04	-0.253000	3.62e-03
Recycling of bile acids and salts	18	6.40e-02	0.252000	1.73e-01
Methylation	14	1.03e-01	-0.252000	2.41e-01
Acyl chain remodelling of PC	26	2.65e-02	0.251000	8.80e-02
Branched-chain amino acid catabolism	20	5.24e-02	-0.250000	1.46e-01
Regulation of PTEN stability and activity	66	4.37e-04	-0.250000	3.25e-03
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	1.05e-01	-0.250000	2.44e-01
MAPK targets/ Nuclear events mediated by MAP kinases	29	2.00e-02	-0.249000	7.13e-02
NoRC negatively regulates rRNA expression	43	4.66e-03	-0.249000	2.34e-02
ERK/MAPK targets	20	5.42e-02	-0.249000	1.49e-01
Hedgehog ‘on’ state	83	9.44e-05	-0.248000	8.53e-04
NOTCH1 Intracellular Domain Regulates Transcription	44	4.52e-03	-0.247000	2.30e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	8.94e-02	-0.245000	2.21e-01
Epigenetic regulation of gene expression	83	1.14e-04	-0.245000	9.85e-04
Regulation of BACH1 activity	15	1.01e-01	-0.244000	2.39e-01
Cholesterol biosynthesis	24	3.84e-02	-0.244000	1.18e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	1.02e-01	-0.244000	2.41e-01
Keratan sulfate degradation	12	1.44e-01	0.243000	3.06e-01
mRNA Splicing - Major Pathway	173	3.35e-08	-0.243000	7.30e-07
Acyl chain remodelling of PI	16	9.23e-02	0.243000	2.26e-01
Thyroxine biosynthesis	10	1.84e-01	0.243000	3.61e-01
SHC-mediated cascade:FGFR1	21	5.43e-02	-0.242000	1.49e-01
Signaling by FLT3 ITD and TKD mutants	16	9.43e-02	-0.241000	2.30e-01
Gap junction trafficking	27	2.99e-02	0.241000	9.75e-02
Adherens junctions interactions	26	3.45e-02	0.239000	1.08e-01
IKK complex recruitment mediated by RIP1	22	5.18e-02	-0.239000	1.46e-01
Formation of Fibrin Clot (Clotting Cascade)	37	1.18e-02	0.239000	4.83e-02
Degradation of cysteine and homocysteine	14	1.22e-01	-0.239000	2.68e-01
Condensation of Prophase Chromosomes	12	1.54e-01	-0.238000	3.19e-01
Xenobiotics	24	4.41e-02	0.237000	1.29e-01
Metabolism of non-coding RNA	50	3.87e-03	-0.236000	2.03e-02
snRNP Assembly	50	3.87e-03	-0.236000	2.03e-02
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	44	6.73e-03	-0.236000	3.17e-02
Keratinization	214	2.56e-09	0.236000	7.53e-08
Regulation of TP53 Expression and Degradation	37	1.30e-02	-0.236000	5.25e-02
RNA Polymerase I Transcription Initiation	42	8.17e-03	-0.236000	3.71e-02
CLEC7A (Dectin-1) signaling	96	6.48e-05	-0.236000	5.95e-04
Cell Cycle Checkpoints	248	1.62e-10	-0.235000	5.15e-09
Gap junction trafficking and regulation	29	2.82e-02	0.235000	9.30e-02
G2/M DNA damage checkpoint	58	2.00e-03	-0.234000	1.17e-02
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	29	2.92e-02	0.234000	9.57e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	1.80e-01	-0.233000	3.56e-01
Activation of the AP-1 family of transcription factors	10	2.02e-01	-0.233000	3.77e-01
Deadenylation-dependent mRNA decay	56	2.58e-03	-0.233000	1.45e-02
Unfolded Protein Response (UPR)	91	1.24e-04	-0.233000	1.05e-03
Negative epigenetic regulation of rRNA expression	45	7.00e-03	-0.232000	3.26e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.83e-01	-0.232000	3.58e-01
Post-chaperonin tubulin folding pathway	23	5.47e-02	-0.231000	1.50e-01
Transport of organic anions	10	2.06e-01	0.231000	3.83e-01
Regulation of TP53 Degradation	36	1.68e-02	-0.230000	6.33e-02
Cellular Senescence	130	6.05e-06	-0.230000	7.77e-05
Phosphorylation of CD3 and TCR zeta chains	20	7.56e-02	-0.229000	1.95e-01
Nuclear events stimulated by ALK signaling in cancer	18	9.20e-02	-0.229000	2.26e-01
Transcriptional regulation of pluripotent stem cells	30	2.97e-02	-0.229000	9.70e-02
G2/M Transition	176	1.51e-07	-0.229000	2.79e-06
Maturation of nucleoprotein	11	1.88e-01	-0.229000	3.65e-01
Mitotic G2-G2/M phases	178	1.37e-07	-0.229000	2.62e-06
Diseases associated with visual transduction	11	1.89e-01	0.228000	3.65e-01
Diseases of the neuronal system	11	1.89e-01	0.228000	3.65e-01
Retinoid cycle disease events	11	1.89e-01	0.228000	3.65e-01
Regulation of TNFR1 signaling	32	2.53e-02	-0.228000	8.53e-02
FCERI mediated NF-kB activation	74	7.12e-04	-0.227000	4.92e-03
DNA Damage/Telomere Stress Induced Senescence	28	3.74e-02	-0.227000	1.16e-01
Trafficking and processing of endosomal TLR	11	1.92e-01	-0.227000	3.67e-01
Processing of Capped Intron-Containing Pre-mRNA	231	2.71e-09	-0.227000	7.66e-08
Chaperonin-mediated protein folding	90	2.01e-04	-0.227000	1.58e-03
TNFR2 non-canonical NF-kB pathway	94	1.48e-04	-0.226000	1.23e-03
Cleavage of the damaged purine	11	1.94e-01	-0.226000	3.69e-01
Depurination	11	1.94e-01	-0.226000	3.69e-01
Recognition and association of DNA glycosylase with site containing an affected purine	11	1.94e-01	-0.226000	3.69e-01
Downregulation of ERBB2:ERBB3 signaling	13	1.58e-01	-0.226000	3.27e-01
Acyl chain remodelling of PG	18	9.79e-02	0.225000	2.35e-01
DNA Double Strand Break Response	42	1.16e-02	-0.225000	4.78e-02
VEGFR2 mediated cell proliferation	19	9.02e-02	-0.224000	2.23e-01
Diseases of carbohydrate metabolism	30	3.38e-02	-0.224000	1.07e-01
Defective Intrinsic Pathway for Apoptosis	25	5.32e-02	-0.223000	1.48e-01
PTEN Regulation	150	2.37e-06	-0.223000	3.42e-05
Transcriptional regulation by RUNX2	116	3.71e-05	-0.222000	3.66e-04
Base-Excision Repair, AP Site Formation	18	1.04e-01	-0.221000	2.42e-01
Removal of the Flap Intermediate from the C-strand	17	1.15e-01	-0.221000	2.58e-01
Antigen processing-Cross presentation	102	1.23e-04	-0.220000	1.05e-03
ER-Phagosome pathway	87	3.90e-04	-0.220000	2.97e-03
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	9.72e-02	-0.220000	2.35e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	9.72e-02	-0.220000	2.35e-01
Regulation of Complement cascade	45	1.08e-02	0.219000	4.62e-02
STING mediated induction of host immune responses	13	1.72e-01	0.219000	3.44e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	2.16e-02	-0.218000	7.49e-02
Regulation of signaling by CBL	18	1.09e-01	0.218000	2.49e-01
Regulation of signaling by NODAL	11	2.11e-01	-0.218000	3.89e-01
Membrane binding and targetting of GAG proteins	14	1.59e-01	-0.217000	3.27e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	1.59e-01	-0.217000	3.27e-01
FLT3 Signaling	38	2.04e-02	-0.217000	7.21e-02
M Phase	336	6.98e-12	-0.217000	2.54e-10
Regulation of TP53 Activity	154	3.33e-06	-0.217000	4.58e-05
Collagen chain trimerization	42	1.51e-02	0.217000	5.87e-02
Selective autophagy	59	4.00e-03	-0.217000	2.08e-02
Complement cascade	56	5.06e-03	0.216000	2.48e-02
Acyl chain remodelling of PE	24	6.69e-02	0.216000	1.78e-01
Intrinsic Pathway for Apoptosis	52	7.22e-03	-0.215000	3.33e-02
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	41	1.72e-02	-0.215000	6.43e-02
Sensory processing of sound by outer hair cells of the cochlea	49	9.41e-03	0.214000	4.14e-02
Cell Cycle, Mitotic	477	9.10e-16	-0.214000	4.79e-14
Downstream TCR signaling	92	3.78e-04	-0.214000	2.89e-03
KEAP1-NFE2L2 pathway	103	1.72e-04	-0.214000	1.39e-03
Global Genome Nucleotide Excision Repair (GG-NER)	81	8.91e-04	-0.213000	5.95e-03
Nucleotide Excision Repair	107	1.36e-04	-0.213000	1.14e-03
MAPK3 (ERK1) activation	10	2.43e-01	-0.213000	4.30e-01
Regulation of beta-cell development	41	1.83e-02	-0.213000	6.73e-02
Disorders of Developmental Biology	11	2.22e-01	-0.213000	4.03e-01
Disorders of Nervous System Development	11	2.22e-01	-0.213000	4.03e-01
Loss of function of MECP2 in Rett syndrome	11	2.22e-01	-0.213000	4.03e-01
Pervasive developmental disorders	11	2.22e-01	-0.213000	4.03e-01
Toll Like Receptor 3 (TLR3) Cascade	88	5.70e-04	-0.212000	4.05e-03
Translocation of ZAP-70 to Immunological synapse	17	1.30e-01	-0.212000	2.81e-01
Inhibition of DNA recombination at telomere	20	1.01e-01	-0.212000	2.39e-01
ZBP1(DAI) mediated induction of type I IFNs	20	1.01e-01	-0.212000	2.39e-01
DNA strand elongation	31	4.11e-02	-0.212000	1.23e-01
Signaling by NOTCH2	32	3.84e-02	-0.211000	1.18e-01
Transcriptional Regulation by TP53	346	1.35e-11	-0.211000	4.57e-10
RMTs methylate histone arginines	29	4.95e-02	-0.211000	1.41e-01
Basigin interactions	24	7.46e-02	-0.210000	1.93e-01
SUMOylation of transcription cofactors	43	1.73e-02	-0.210000	6.45e-02
Removal of the Flap Intermediate	13	1.91e-01	-0.210000	3.65e-01
Cellular responses to stress	683	7.65e-21	-0.209000	8.99e-19
Activation of AMPK downstream of NMDARs	10	2.52e-01	-0.209000	4.37e-01
Cellular responses to stimuli	697	3.83e-21	-0.209000	4.88e-19
Downregulation of SMAD2/3:SMAD4 transcriptional activity	26	6.53e-02	-0.209000	1.74e-01
Alpha-protein kinase 1 signaling pathway	10	2.54e-01	-0.208000	4.39e-01
Na+/Cl- dependent neurotransmitter transporters	18	1.26e-01	0.208000	2.77e-01
Transcriptional Regulation by E2F6	32	4.18e-02	-0.208000	1.24e-01
Mitochondrial calcium ion transport	22	9.25e-02	-0.207000	2.26e-01
RNA Polymerase III Transcription Termination	23	8.64e-02	-0.206000	2.16e-01
AURKA Activation by TPX2	68	3.22e-03	-0.206000	1.75e-02
Formation of Incision Complex in GG-NER	40	2.39e-02	-0.206000	8.16e-02
Deactivation of the beta-catenin transactivating complex	39	2.57e-02	-0.206000	8.63e-02
Mitochondrial protein import	54	9.11e-03	-0.205000	4.02e-02
TP53 Regulates Transcription of DNA Repair Genes	57	7.40e-03	-0.205000	3.41e-02
Glutamate and glutamine metabolism	12	2.19e-01	-0.205000	4.01e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	2.21e-01	-0.204000	4.03e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	1.71e-01	0.204000	3.44e-01
Apoptosis	164	6.54e-06	-0.204000	8.33e-05
HSF1-dependent transactivation	35	3.71e-02	-0.204000	1.15e-01
Peptide hormone biosynthesis	11	2.42e-01	0.204000	4.29e-01
Signaling by Activin	15	1.72e-01	-0.204000	3.44e-01
Assembly Of The HIV Virion	16	1.59e-01	-0.203000	3.27e-01
Generic Transcription Pathway	1150	1.69e-31	-0.203000	5.16e-29
Receptor Mediated Mitophagy	10	2.66e-01	-0.203000	4.52e-01
NRAGE signals death through JNK	53	1.06e-02	0.203000	4.57e-02
AKT phosphorylates targets in the cytosol	14	1.89e-01	-0.202000	3.65e-01
Ub-specific processing proteases	157	1.27e-05	-0.202000	1.42e-04
Signaling by Erythropoietin	25	8.09e-02	-0.202000	2.05e-01
ECM proteoglycans	55	1.01e-02	0.200000	4.37e-02
GAB1 signalosome	17	1.53e-01	0.200000	3.18e-01
Protein localization	147	2.77e-05	-0.200000	2.86e-04
Tandem pore domain potassium channels	12	2.30e-01	-0.200000	4.12e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	2.61e-03	-0.200000	1.47e-02
Protein folding	96	7.70e-04	-0.198000	5.30e-03
Estrogen-dependent gene expression	91	1.06e-03	-0.198000	6.90e-03
Cellular response to heat stress	95	8.23e-04	-0.198000	5.57e-03
Processing of Capped Intronless Pre-mRNA	28	6.91e-02	-0.198000	1.83e-01
TCR signaling	112	2.83e-04	-0.198000	2.18e-03
RNA polymerase II transcribes snRNA genes	77	2.63e-03	-0.198000	1.47e-02
RHO GTPases activate PKNs	34	4.55e-02	-0.198000	1.32e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	2.79e-01	-0.198000	4.64e-01
ERBB2 Activates PTK6 Signaling	13	2.18e-01	0.197000	4.00e-01
p130Cas linkage to MAPK signaling for integrins	15	1.87e-01	0.197000	3.65e-01
RNA Polymerase II Transcription	1271	1.98e-32	-0.197000	1.01e-29
Metabolism of amino acids and derivatives	345	3.28e-10	-0.197000	1.02e-08
Reversible hydration of carbon dioxide	11	2.59e-01	-0.197000	4.44e-01
TCF dependent signaling in response to WNT	168	1.11e-05	-0.196000	1.27e-04
Chaperone Mediated Autophagy	19	1.39e-01	-0.196000	2.98e-01
Toll Like Receptor 9 (TLR9) Cascade	88	1.53e-03	-0.195000	9.54e-03
Drug ADME	98	8.29e-04	0.195000	5.58e-03
Sema4D induced cell migration and growth-cone collapse	20	1.31e-01	-0.195000	2.84e-01
TRAF6 mediated NF-kB activation	24	9.79e-02	-0.195000	2.35e-01
Programmed Cell Death	192	3.06e-06	-0.195000	4.28e-05
ABC transporter disorders	75	3.52e-03	-0.195000	1.88e-02
Phase 2 - plateau phase	14	2.08e-01	0.194000	3.86e-01
Purine salvage	12	2.44e-01	-0.194000	4.30e-01
Regulation of PLK1 Activity at G2/M Transition	83	2.22e-03	-0.194000	1.28e-02
MyD88 dependent cascade initiated on endosome	84	2.13e-03	-0.194000	1.24e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade	84	2.13e-03	-0.194000	1.24e-02
MET promotes cell motility	29	7.09e-02	0.194000	1.85e-01
G0 and Early G1	27	8.14e-02	-0.194000	2.06e-01
Mitotic Spindle Checkpoint	106	5.73e-04	-0.193000	4.05e-03
Iron uptake and transport	57	1.16e-02	-0.193000	4.79e-02
Beta-catenin phosphorylation cascade	16	1.82e-01	-0.193000	3.57e-01
Assembly of the ORC complex at the origin of replication	10	2.91e-01	0.193000	4.75e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	2.48e-01	-0.193000	4.35e-01
STAT5 activation downstream of FLT3 ITD mutants	10	2.93e-01	-0.192000	4.76e-01
Recycling pathway of L1	23	1.11e-01	0.192000	2.52e-01
Activation of HOX genes during differentiation	61	9.63e-03	-0.192000	4.18e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis	61	9.63e-03	-0.192000	4.18e-02
TNF signaling	40	3.63e-02	-0.191000	1.13e-01
PECAM1 interactions	12	2.51e-01	0.191000	4.37e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	2.01e-01	-0.191000	3.76e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	2.01e-01	-0.191000	3.76e-01
Gene expression (Transcription)	1407	1.37e-33	-0.191000	1.04e-30
Neddylation	228	6.75e-07	-0.191000	1.10e-05
MyD88 cascade initiated on plasma membrane	79	3.47e-03	-0.190000	1.86e-02
Toll Like Receptor 10 (TLR10) Cascade	79	3.47e-03	-0.190000	1.86e-02
Toll Like Receptor 5 (TLR5) Cascade	79	3.47e-03	-0.190000	1.86e-02
tRNA processing in the nucleus	55	1.48e-02	-0.190000	5.76e-02
Oxidative Stress Induced Senescence	66	7.89e-03	-0.189000	3.61e-02
MyD88-independent TLR4 cascade	92	1.80e-03	-0.188000	1.09e-02
TRIF(TICAM1)-mediated TLR4 signaling	92	1.80e-03	-0.188000	1.09e-02
Cell Cycle	602	2.70e-15	-0.188000	1.33e-13
Telomere C-strand synthesis initiation	11	2.81e-01	-0.188000	4.66e-01
Processing of DNA double-strand break ends	61	1.13e-02	-0.187000	4.72e-02
Processing of Intronless Pre-mRNAs	19	1.60e-01	-0.186000	3.28e-01
Adenylate cyclase activating pathway	10	3.08e-01	0.186000	4.88e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	3.09e-01	-0.186000	4.88e-01
Digestion and absorption	26	1.01e-01	0.186000	2.39e-01
Impaired BRCA2 binding to RAD51	33	6.50e-02	-0.186000	1.74e-01
Interaction With Cumulus Cells And The Zona Pellucida	11	2.87e-01	0.185000	4.70e-01
Serotonin receptors	11	2.87e-01	0.185000	4.71e-01
PKA activation in glucagon signalling	17	1.86e-01	0.185000	3.64e-01
SHC-mediated cascade:FGFR3	17	1.87e-01	-0.185000	3.65e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	83	3.60e-03	-0.185000	1.92e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	1.91e-02	-0.184000	6.89e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	1.91e-02	-0.184000	6.89e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	1.91e-02	-0.184000	6.89e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	1.91e-02	-0.184000	6.89e-02
Signaling by NOTCH1 in Cancer	54	1.91e-02	-0.184000	6.89e-02
Signaling by NTRK1 (TRKA)	114	6.75e-04	-0.184000	4.69e-03
Host Interactions of HIV factors	122	4.39e-04	-0.184000	3.26e-03
PI3K events in ERBB4 signaling	10	3.14e-01	0.184000	4.92e-01
Transcriptional activation of mitochondrial biogenesis	51	2.32e-02	-0.184000	7.97e-02
Pyrimidine salvage	10	3.15e-01	0.183000	4.94e-01
Transcription of E2F targets under negative control by DREAM complex	19	1.66e-01	-0.183000	3.36e-01
Activation of ATR in response to replication stress	37	5.35e-02	-0.183000	1.48e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	8.22e-02	-0.183000	2.07e-01
Crosslinking of collagen fibrils	10	3.16e-01	-0.183000	4.95e-01
Interleukin-1 signaling	97	1.87e-03	-0.183000	1.12e-02
Acetylcholine binding and downstream events	14	2.38e-01	-0.182000	4.23e-01
Postsynaptic nicotinic acetylcholine receptors	14	2.38e-01	-0.182000	4.23e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	2.08e-01	-0.182000	3.86e-01
Activation of SMO	17	1.95e-01	-0.181000	3.69e-01
Cell-cell junction organization	56	1.90e-02	0.181000	6.89e-02
HIV Transcription Initiation	43	4.06e-02	-0.180000	1.22e-01
RNA Polymerase II HIV Promoter Escape	43	4.06e-02	-0.180000	1.22e-01
RNA Polymerase II Promoter Escape	43	4.06e-02	-0.180000	1.22e-01
RNA Polymerase II Transcription Initiation	43	4.06e-02	-0.180000	1.22e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	4.06e-02	-0.180000	1.22e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	4.06e-02	-0.180000	1.22e-01
Androgen biosynthesis	11	3.01e-01	0.180000	4.82e-01
Antimicrobial peptides	82	4.89e-03	0.180000	2.42e-02
Glyoxylate metabolism and glycine degradation	30	8.87e-02	-0.179000	2.20e-01
LGI-ADAM interactions	14	2.45e-01	-0.179000	4.31e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	3.26e-01	-0.179000	5.05e-01
IRF3-mediated induction of type I IFN	11	3.03e-01	0.179000	4.85e-01
Signaling by FLT3 fusion proteins	19	1.78e-01	-0.178000	3.52e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	6.44e-02	-0.178000	1.73e-01
Lysosome Vesicle Biogenesis	33	7.67e-02	-0.178000	1.97e-01
Gluconeogenesis	32	8.17e-02	-0.178000	2.06e-01
Hedgehog ‘off’ state	97	2.55e-03	-0.177000	1.44e-02
tRNA processing	98	2.46e-03	-0.177000	1.40e-02
Response to metal ions	14	2.53e-01	-0.177000	4.38e-01
Heme biosynthesis	13	2.72e-01	-0.176000	4.59e-01
HDACs deacetylate histones	29	1.02e-01	-0.175000	2.41e-01
Activation of gene expression by SREBF (SREBP)	42	4.92e-02	-0.175000	1.41e-01
Phase 0 - rapid depolarisation	31	9.12e-02	0.175000	2.25e-01
N-glycan antennae elongation in the medial/trans-Golgi	26	1.22e-01	0.175000	2.68e-01
Synthesis of PA	35	7.30e-02	0.175000	1.91e-01
SUMOylation of chromatin organization proteins	54	2.65e-02	-0.174000	8.80e-02
Plasma lipoprotein clearance	37	6.74e-02	-0.174000	1.79e-01
Transcription of the HIV genome	62	1.80e-02	-0.174000	6.65e-02
Resolution of Sister Chromatid Cohesion	98	3.04e-03	-0.173000	1.66e-02
SUMOylation of SUMOylation proteins	33	8.54e-02	-0.173000	2.14e-01
CYP2E1 reactions	11	3.21e-01	0.173000	4.99e-01
Loss of Nlp from mitotic centrosomes	65	1.61e-02	-0.173000	6.14e-02
Loss of proteins required for interphase microtubule organization from the centrosome	65	1.61e-02	-0.173000	6.14e-02
Dectin-2 family	28	1.17e-01	0.171000	2.60e-01
Signaling by TGF-beta Receptor Complex	86	6.08e-03	-0.171000	2.91e-02
SUMOylation of RNA binding proteins	45	4.71e-02	-0.171000	1.36e-01
MAP kinase activation	58	2.44e-02	-0.171000	8.30e-02
SHC-mediated cascade:FGFR4	19	1.99e-01	-0.170000	3.74e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	1.14e-02	-0.170000	4.73e-02
Resolution of Abasic Sites (AP sites)	37	7.34e-02	-0.170000	1.91e-01
Stimuli-sensing channels	96	3.98e-03	0.170000	2.08e-02
Interleukin-4 and Interleukin-13 signaling	104	2.73e-03	-0.170000	1.52e-02
PD-1 signaling	21	1.78e-01	-0.170000	3.52e-01
RNA Polymerase II Transcription Termination	62	2.07e-02	-0.170000	7.30e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	1.20e-01	-0.170000	2.67e-01
SUMOylation	164	1.76e-04	-0.170000	1.41e-03
L1CAM interactions	92	5.05e-03	0.169000	2.48e-02
Negative regulation of FGFR1 signaling	32	9.80e-02	-0.169000	2.35e-01
Processive synthesis on the lagging strand	14	2.76e-01	-0.168000	4.62e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	2.20e-02	-0.168000	7.61e-02
Synthesis of very long-chain fatty acyl-CoAs	23	1.63e-01	0.168000	3.32e-01
Assembly of active LPL and LIPC lipase complexes	17	2.32e-01	0.168000	4.14e-01
Creation of C4 and C2 activators	14	2.79e-01	0.167000	4.64e-01
Mitochondrial biogenesis	69	1.65e-02	-0.167000	6.27e-02
Base Excision Repair	45	5.30e-02	-0.167000	1.47e-01
Paracetamol ADME	30	1.14e-01	0.166000	2.57e-01
Interleukin-7 signaling	21	1.88e-01	-0.166000	3.65e-01
Transferrin endocytosis and recycling	30	1.15e-01	-0.166000	2.58e-01
RNA Polymerase II Pre-transcription Events	73	1.42e-02	-0.166000	5.55e-02
Digestion	21	1.89e-01	0.166000	3.65e-01
Other semaphorin interactions	18	2.24e-01	0.166000	4.06e-01
Mitotic Prometaphase	175	1.58e-04	-0.165000	1.30e-03
ROS and RNS production in phagocytes	35	9.13e-02	-0.165000	2.25e-01
Metabolism of cofactors	19	2.14e-01	-0.165000	3.93e-01
Mitotic Prophase	78	1.18e-02	-0.165000	4.83e-02
Sensory processing of sound	69	1.80e-02	0.165000	6.65e-02
HDR through Single Strand Annealing (SSA)	36	8.74e-02	-0.165000	2.17e-01
Pre-NOTCH Processing in Golgi	18	2.27e-01	-0.165000	4.07e-01
Deubiquitination	230	1.74e-05	-0.164000	1.89e-04
The phototransduction cascade	32	1.08e-01	0.164000	2.49e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	43	6.30e-02	0.164000	1.70e-01
Myogenesis	29	1.29e-01	0.163000	2.81e-01
SUMO E3 ligases SUMOylate target proteins	158	4.63e-04	-0.161000	3.41e-03
Mucopolysaccharidoses	10	3.77e-01	-0.161000	5.52e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	31	1.20e-01	-0.161000	2.67e-01
Regulation of IFNG signaling	14	2.97e-01	-0.161000	4.79e-01
Pyruvate metabolism	29	1.34e-01	-0.161000	2.90e-01
Transcriptional regulation by RUNX1	183	1.76e-04	-0.161000	1.41e-03
PI-3K cascade:FGFR3	17	2.52e-01	0.160000	4.37e-01
Glycogen metabolism	24	1.73e-01	-0.160000	3.45e-01
mRNA 3’-end processing	53	4.33e-02	-0.160000	1.27e-01
RNA Polymerase III Chain Elongation	18	2.39e-01	-0.160000	4.25e-01
SHC1 events in ERBB4 signaling	14	3.00e-01	-0.160000	4.82e-01
HDR through Homologous Recombination (HRR)	65	2.62e-02	-0.159000	8.74e-02
Tryptophan catabolism	12	3.40e-01	0.159000	5.19e-01
Platelet Adhesion to exposed collagen	13	3.22e-01	0.159000	4.99e-01
IRE1alpha activates chaperones	50	5.26e-02	-0.158000	1.46e-01
Insulin receptor recycling	25	1.70e-01	-0.158000	3.43e-01
Cytosolic sensors of pathogen-associated DNA	60	3.38e-02	-0.158000	1.07e-01
Nuclear Receptor transcription pathway	51	5.13e-02	-0.158000	1.45e-01
HS-GAG biosynthesis	28	1.49e-01	0.157000	3.14e-01
Sensory processing of sound by inner hair cells of the cochlea	62	3.21e-02	0.157000	1.02e-01
Adenylate cyclase inhibitory pathway	14	3.08e-01	0.157000	4.88e-01
Cleavage of the damaged pyrimidine	16	2.76e-01	-0.157000	4.62e-01
Depyrimidination	16	2.76e-01	-0.157000	4.62e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	2.76e-01	-0.157000	4.62e-01
Signalling to ERKs	34	1.14e-01	-0.156000	2.57e-01
Negative regulators of DDX58/IFIH1 signaling	34	1.15e-01	-0.156000	2.58e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	23	1.96e-01	-0.156000	3.69e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	23	1.96e-01	-0.156000	3.69e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	23	1.96e-01	-0.156000	3.69e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	23	1.96e-01	-0.156000	3.69e-01
Impaired BRCA2 binding to PALB2	23	1.96e-01	-0.156000	3.69e-01
RAB geranylgeranylation	57	4.18e-02	-0.156000	1.24e-01
Phase 4 - resting membrane potential	19	2.40e-01	-0.156000	4.26e-01
NR1H2 and NR1H3-mediated signaling	53	5.00e-02	0.156000	1.42e-01
G1/S-Specific Transcription	28	1.55e-01	-0.155000	3.20e-01
Activation of RAC1	11	3.72e-01	0.155000	5.50e-01
Signaling by the B Cell Receptor (BCR)	105	5.92e-03	-0.155000	2.84e-02
Collagen biosynthesis and modifying enzymes	65	3.14e-02	0.154000	1.01e-01
Presynaptic nicotinic acetylcholine receptors	12	3.55e-01	-0.154000	5.36e-01
Activation of BAD and translocation to mitochondria	15	3.01e-01	-0.154000	4.82e-01
Physiological factors	12	3.55e-01	0.154000	5.36e-01
RHOB GTPase cycle	66	3.05e-02	0.154000	9.90e-02
Defective B3GALTL causes PpS	36	1.10e-01	0.154000	2.51e-01
Acetylcholine regulates insulin secretion	10	4.00e-01	0.154000	5.73e-01
VxPx cargo-targeting to cilium	20	2.34e-01	0.154000	4.18e-01
Regulation of TP53 Activity through Acetylation	29	1.53e-01	-0.153000	3.18e-01
FGFR2 alternative splicing	26	1.76e-01	-0.153000	3.50e-01
Regulation of FZD by ubiquitination	21	2.24e-01	-0.153000	4.06e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	38	1.03e-01	-0.153000	2.41e-01
HIV Transcription Elongation	38	1.03e-01	-0.153000	2.41e-01
Tat-mediated elongation of the HIV-1 transcript	38	1.03e-01	-0.153000	2.41e-01
TGF-beta receptor signaling activates SMADs	45	7.59e-02	-0.153000	1.96e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	38	1.03e-01	-0.153000	2.41e-01
NOD1/2 Signaling Pathway	29	1.56e-01	-0.152000	3.22e-01
HIV Infection	216	1.14e-04	-0.152000	9.85e-04
eNOS activation	11	3.83e-01	-0.152000	5.56e-01
Activation of the pre-replicative complex	31	1.43e-01	-0.152000	3.04e-01
Chemokine receptors bind chemokines	56	4.96e-02	0.152000	1.41e-01
Pausing and recovery of Tat-mediated HIV elongation	27	1.73e-01	-0.152000	3.44e-01
Tat-mediated HIV elongation arrest and recovery	27	1.73e-01	-0.152000	3.44e-01
Nuclear import of Rev protein	32	1.38e-01	-0.152000	2.96e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	5.41e-02	-0.151000	1.49e-01
RHOU GTPase cycle	37	1.11e-01	0.151000	2.52e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	89	1.35e-02	-0.151000	5.39e-02
Amplification of signal from the kinetochores	89	1.35e-02	-0.151000	5.39e-02
Formation of HIV elongation complex in the absence of HIV Tat	40	9.76e-02	-0.151000	2.35e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	94	1.13e-02	-0.151000	4.72e-02
Toll Like Receptor 2 (TLR2) Cascade	94	1.13e-02	-0.151000	4.72e-02
Toll Like Receptor TLR1:TLR2 Cascade	94	1.13e-02	-0.151000	4.72e-02
Toll Like Receptor TLR6:TLR2 Cascade	94	1.13e-02	-0.151000	4.72e-02
Dual incision in TC-NER	63	3.84e-02	-0.151000	1.18e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	3.87e-01	-0.151000	5.59e-01
Export of Viral Ribonucleoproteins from Nucleus	31	1.47e-01	-0.150000	3.11e-01
Recognition of DNA damage by PCNA-containing replication complex	29	1.61e-01	-0.150000	3.30e-01
Signaling by EGFR in Cancer	25	1.94e-01	-0.150000	3.69e-01
Homologous DNA Pairing and Strand Exchange	41	9.73e-02	-0.150000	2.35e-01
Beta-catenin independent WNT signaling	144	1.93e-03	-0.150000	1.15e-02
XBP1(S) activates chaperone genes	48	7.31e-02	-0.149000	1.91e-01
HIV elongation arrest and recovery	29	1.64e-01	-0.149000	3.32e-01
Pausing and recovery of HIV elongation	29	1.64e-01	-0.149000	3.32e-01
Early Phase of HIV Life Cycle	14	3.34e-01	-0.149000	5.12e-01
RHO GTPases Activate ROCKs	19	2.63e-01	-0.148000	4.48e-01
RNA Polymerase III Abortive And Retractive Initiation	41	1.01e-01	-0.148000	2.39e-01
RNA Polymerase III Transcription	41	1.01e-01	-0.148000	2.39e-01
Synaptic adhesion-like molecules	19	2.65e-01	-0.148000	4.50e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	2.01e-01	-0.148000	3.76e-01
Cellular response to chemical stress	187	4.91e-04	-0.148000	3.57e-03
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	7.43e-02	-0.147000	1.93e-01
HIV Life Cycle	139	2.70e-03	-0.147000	1.51e-02
Late Phase of HIV Life Cycle	126	4.30e-03	-0.147000	2.21e-02
O-glycosylation of TSR domain-containing proteins	37	1.21e-01	0.147000	2.67e-01
Signaling by NTRK3 (TRKC)	17	2.93e-01	-0.147000	4.77e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	1.13e-01	-0.147000	2.55e-01
Diseases of DNA Double-Strand Break Repair	39	1.13e-01	-0.147000	2.55e-01
Signaling by WNT	263	4.26e-05	-0.146000	4.10e-04
Synthesis of PC	27	1.88e-01	-0.146000	3.65e-01
Signaling by KIT in disease	20	2.57e-01	-0.146000	4.42e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	2.57e-01	-0.146000	4.42e-01
Aspartate and asparagine metabolism	12	3.81e-01	0.146000	5.54e-01
RAF activation	33	1.46e-01	-0.146000	3.10e-01
Generation of second messenger molecules	30	1.66e-01	-0.146000	3.36e-01
Signaling by TGFB family members	114	7.12e-03	-0.146000	3.31e-02
Signaling by FGFR3	39	1.15e-01	-0.146000	2.58e-01
Resolution of D-Loop Structures	32	1.54e-01	-0.146000	3.19e-01
MET activates RAP1 and RAC1	11	4.03e-01	0.146000	5.77e-01
Signaling by FGFR1	49	7.81e-02	-0.145000	2.00e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	4.04e-01	0.145000	5.78e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	52	7.04e-02	-0.145000	1.85e-01
Homology Directed Repair	100	1.22e-02	-0.145000	4.96e-02
Glucose metabolism	87	1.99e-02	-0.144000	7.10e-02
Interleukin-15 signaling	13	3.69e-01	-0.144000	5.50e-01
Toll-like Receptor Cascades	143	2.98e-03	-0.144000	1.64e-02
Prolactin receptor signaling	15	3.35e-01	-0.144000	5.13e-01
Bicarbonate transporters	10	4.32e-01	0.143000	6.06e-01
Interactions of Rev with host cellular proteins	35	1.42e-01	-0.143000	3.01e-01
Growth hormone receptor signaling	24	2.24e-01	-0.143000	4.06e-01
Lewis blood group biosynthesis	18	2.92e-01	0.143000	4.76e-01
Recruitment of NuMA to mitotic centrosomes	76	3.11e-02	-0.143000	1.00e-01
Visual phototransduction	93	1.72e-02	0.143000	6.43e-02
Inactivation, recovery and regulation of the phototransduction cascade	31	1.69e-01	0.143000	3.40e-01
RHOJ GTPase cycle	51	7.82e-02	0.142000	2.00e-01
ABC-family proteins mediated transport	98	1.48e-02	-0.142000	5.76e-02
APC truncation mutants have impaired AXIN binding	13	3.74e-01	-0.142000	5.50e-01
AXIN missense mutants destabilize the destruction complex	13	3.74e-01	-0.142000	5.50e-01
Signaling by AMER1 mutants	13	3.74e-01	-0.142000	5.50e-01
Signaling by APC mutants	13	3.74e-01	-0.142000	5.50e-01
Signaling by AXIN mutants	13	3.74e-01	-0.142000	5.50e-01
Truncations of AMER1 destabilize the destruction complex	13	3.74e-01	-0.142000	5.50e-01
Purine ribonucleoside monophosphate biosynthesis	11	4.14e-01	-0.142000	5.88e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	2.19e-01	-0.142000	4.01e-01
Glycolysis	68	4.32e-02	-0.142000	1.27e-01
VEGFR2 mediated vascular permeability	26	2.12e-01	0.141000	3.91e-01
Translesion Synthesis by POLH	19	2.88e-01	-0.141000	4.71e-01
Signaling by NTRKs	133	5.00e-03	-0.141000	2.47e-02
Telomere Extension By Telomerase	22	2.55e-01	-0.140000	4.40e-01
DNA Repair	277	6.10e-05	-0.140000	5.69e-04
DNA Double-Strand Break Repair	130	5.89e-03	-0.140000	2.83e-02
FRS-mediated FGFR1 signaling	23	2.47e-01	-0.139000	4.33e-01
C-type lectin receptors (CLRs)	137	4.84e-03	-0.139000	2.41e-02
ESR-mediated signaling	160	2.34e-03	-0.139000	1.33e-02
Centrosome maturation	77	3.45e-02	-0.139000	1.08e-01
Recruitment of mitotic centrosome proteins and complexes	77	3.45e-02	-0.139000	1.08e-01
TP53 Regulates Metabolic Genes	83	2.84e-02	-0.139000	9.36e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript	67	4.94e-02	-0.139000	1.41e-01
PI-3K cascade:FGFR4	19	2.95e-01	0.139000	4.78e-01
RHOBTB1 GTPase cycle	22	2.61e-01	-0.138000	4.46e-01
Synthesis, secretion, and deacylation of Ghrelin	19	2.96e-01	-0.138000	4.79e-01
RHO GTPases Activate WASPs and WAVEs	34	1.63e-01	-0.138000	3.32e-01
RHO GTPases activate IQGAPs	11	4.27e-01	0.138000	6.00e-01
SUMOylation of DNA replication proteins	44	1.13e-01	-0.138000	2.55e-01
Metabolism of Angiotensinogen to Angiotensins	15	3.55e-01	0.138000	5.36e-01
G alpha (i) signalling events	306	3.28e-05	0.138000	3.28e-04
Fanconi Anemia Pathway	37	1.47e-01	-0.138000	3.10e-01
RHO GTPases Activate Formins	114	1.11e-02	-0.138000	4.70e-02
SUMOylation of DNA damage response and repair proteins	71	4.50e-02	-0.137000	1.31e-01
Translesion synthesis by POLI	17	3.28e-01	-0.137000	5.07e-01
Infection with Mycobacterium tuberculosis	26	2.27e-01	-0.137000	4.07e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	2.10e-01	-0.137000	3.89e-01
Processing of SMDT1	15	3.60e-01	-0.137000	5.38e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	4.33e-01	-0.137000	6.07e-01
Processive synthesis on the C-strand of the telomere	19	3.04e-01	-0.136000	4.86e-01
COPII-mediated vesicle transport	66	5.57e-02	-0.136000	1.53e-01
Receptor-type tyrosine-protein phosphatases	16	3.49e-01	0.135000	5.30e-01
Deadenylation of mRNA	25	2.42e-01	-0.135000	4.28e-01
Signaling by NOTCH	183	1.63e-03	-0.135000	1.00e-02
SHC-mediated cascade:FGFR2	22	2.73e-01	-0.135000	4.61e-01
IL-6-type cytokine receptor ligand interactions	17	3.36e-01	-0.135000	5.14e-01
Synthesis of substrates in N-glycan biosythesis	60	7.33e-02	-0.134000	1.91e-01
Rev-mediated nuclear export of HIV RNA	33	1.85e-01	-0.133000	3.62e-01
Formation of RNA Pol II elongation complex	53	9.50e-02	-0.133000	2.31e-01
RNA Polymerase II Transcription Elongation	53	9.50e-02	-0.133000	2.31e-01
Defective C1GALT1C1 causes TNPS	18	3.30e-01	0.132000	5.10e-01
Class B/2 (Secretin family receptors)	94	2.65e-02	-0.132000	8.80e-02
Cell junction organization	79	4.21e-02	0.132000	1.25e-01
Defective GALNT12 causes CRCS1	18	3.31e-01	0.132000	5.10e-01
Signaling by FGFR2	72	5.23e-02	-0.132000	1.46e-01
mRNA Capping	28	2.26e-01	-0.132000	4.07e-01
TNFR1-induced proapoptotic signaling	13	4.10e-01	-0.132000	5.84e-01
PI-3K cascade:FGFR2	22	2.84e-01	0.132000	4.68e-01
tRNA modification in the nucleus and cytosol	38	1.59e-01	-0.132000	3.27e-01
Potential therapeutics for SARS	83	3.79e-02	-0.132000	1.17e-01
Aggrephagy	23	2.80e-01	-0.130000	4.66e-01
SUMOylation of ubiquitinylation proteins	37	1.72e-01	-0.130000	3.44e-01
Fc epsilon receptor (FCERI) signaling	126	1.18e-02	-0.130000	4.83e-02
Endosomal/Vacuolar pathway	12	4.38e-01	0.129000	6.11e-01
Long-term potentiation	22	2.93e-01	0.129000	4.77e-01
TBC/RABGAPs	42	1.47e-01	-0.129000	3.10e-01
activated TAK1 mediates p38 MAPK activation	16	3.71e-01	-0.129000	5.50e-01
Nonhomologous End-Joining (NHEJ)	32	2.06e-01	-0.129000	3.83e-01
SARS-CoV Infections	339	4.36e-05	-0.129000	4.17e-04
Unblocking of NMDA receptors, glutamate binding and activation	19	3.31e-01	0.129000	5.10e-01
Collagen degradation	39	1.64e-01	0.129000	3.33e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	94	3.13e-02	-0.128000	1.01e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	22	2.98e-01	-0.128000	4.80e-01
Neurodegenerative Diseases	22	2.98e-01	-0.128000	4.80e-01
Response of Mtb to phagocytosis	22	2.98e-01	-0.128000	4.80e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	4.42e-01	0.128000	6.15e-01
Defective EXT2 causes exostoses 2	12	4.42e-01	0.128000	6.15e-01
Lysine catabolism	12	4.43e-01	0.128000	6.15e-01
Presynaptic phase of homologous DNA pairing and strand exchange	38	1.73e-01	-0.128000	3.44e-01
Signaling by FGFR	85	4.16e-02	-0.128000	1.24e-01
Sema4D in semaphorin signaling	24	2.79e-01	-0.128000	4.64e-01
CRMPs in Sema3A signaling	15	3.92e-01	0.127000	5.64e-01
Mitochondrial tRNA aminoacylation	18	3.49e-01	-0.127000	5.30e-01
Postmitotic nuclear pore complex (NPC) reformation	26	2.61e-01	-0.127000	4.46e-01
Metal ion SLC transporters	25	2.71e-01	-0.127000	4.58e-01
Sulfur amino acid metabolism	27	2.56e-01	-0.126000	4.41e-01
Toll Like Receptor 4 (TLR4) Cascade	124	1.58e-02	-0.125000	6.06e-02
Metabolism of folate and pterines	16	3.86e-01	0.125000	5.57e-01
Metabolism of proteins	1774	1.18e-18	-0.125000	1.00e-16
COPI-dependent Golgi-to-ER retrograde traffic	81	5.16e-02	-0.125000	1.45e-01
Advanced glycosylation endproduct receptor signaling	13	4.35e-01	-0.125000	6.09e-01
Dual Incision in GG-NER	39	1.77e-01	-0.125000	3.51e-01
MECP2 regulates neuronal receptors and channels	17	3.73e-01	0.125000	5.50e-01
O-linked glycosylation	107	2.59e-02	0.125000	8.69e-02
SARS-CoV-2 Infection	265	4.84e-04	-0.124000	3.54e-03
EPHA-mediated growth cone collapse	15	4.05e-01	0.124000	5.78e-01
Interleukin-27 signaling	11	4.76e-01	-0.124000	6.48e-01
Chylomicron assembly	10	4.99e-01	-0.124000	6.67e-01
Signaling by FGFR4	40	1.77e-01	-0.123000	3.50e-01
Cell-Cell communication	112	2.40e-02	0.123000	8.17e-02
Downstream signal transduction	29	2.50e-01	-0.123000	4.36e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	4.59e-01	-0.123000	6.32e-01
Negative regulation of FGFR3 signaling	28	2.58e-01	-0.123000	4.44e-01
Interleukin-6 family signaling	24	2.95e-01	-0.123000	4.78e-01
EML4 and NUDC in mitotic spindle formation	93	3.98e-02	-0.123000	1.21e-01
RHO GTPases activate CIT	19	3.53e-01	-0.123000	5.35e-01
Synthesis of PIPs at the plasma membrane	48	1.40e-01	0.123000	2.99e-01
NEP/NS2 Interacts with the Cellular Export Machinery	30	2.44e-01	-0.123000	4.30e-01
FGFR1 ligand binding and activation	15	4.13e-01	-0.122000	5.87e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	3.57e-01	-0.122000	5.38e-01
Interleukin-12 family signaling	54	1.21e-01	-0.122000	2.67e-01
Cytosolic iron-sulfur cluster assembly	10	5.04e-01	0.122000	6.70e-01
Transport of the SLBP independent Mature mRNA	33	2.25e-01	-0.122000	4.07e-01
RHO GTPase Effectors	232	1.37e-03	-0.122000	8.72e-03
Peroxisomal protein import	62	9.72e-02	-0.122000	2.35e-01
RHOQ GTPase cycle	57	1.12e-01	0.122000	2.55e-01
Signaling by ERBB2 ECD mutants	15	4.15e-01	-0.122000	5.88e-01
RNA Pol II CTD phosphorylation and interaction with CE	26	2.83e-01	-0.122000	4.68e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	2.83e-01	-0.122000	4.68e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	4.67e-01	-0.121000	6.40e-01
Ovarian tumor domain proteases	36	2.12e-01	-0.120000	3.90e-01
Signaling by Hedgehog	133	1.68e-02	-0.120000	6.33e-02
Meiotic synapsis	32	2.46e-01	-0.118000	4.32e-01
Macroautophagy	111	3.10e-02	-0.118000	1.00e-01
Negative regulation of FGFR4 signaling	30	2.62e-01	-0.118000	4.48e-01
Formation of the cornified envelope	74	7.86e-02	0.118000	2.01e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	4.99e-01	-0.118000	6.67e-01
Degradation of the extracellular matrix	108	3.46e-02	0.118000	1.08e-01
Signaling by ALK	26	2.99e-01	-0.118000	4.81e-01
Cargo concentration in the ER	32	2.50e-01	-0.118000	4.36e-01
Signaling by Hippo	19	3.75e-01	0.117000	5.50e-01
Collagen formation	88	5.69e-02	0.117000	1.55e-01
RNA Polymerase III Transcription Initiation	36	2.25e-01	-0.117000	4.07e-01
PLC beta mediated events	47	1.66e-01	0.117000	3.36e-01
Non-integrin membrane-ECM interactions	40	2.02e-01	0.117000	3.77e-01
HS-GAG degradation	18	3.92e-01	-0.116000	5.64e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	4.35e-01	-0.116000	6.09e-01
Cytoprotection by HMOX1	58	1.25e-01	-0.116000	2.75e-01
Interactions of Vpr with host cellular proteins	33	2.49e-01	-0.116000	4.35e-01
GABA synthesis, release, reuptake and degradation	19	3.82e-01	-0.116000	5.55e-01
Diseases associated with glycosylation precursor biosynthesis	15	4.37e-01	-0.116000	6.11e-01
Transport of Mature Transcript to Cytoplasm	76	8.12e-02	-0.116000	2.06e-01
G-protein mediated events	52	1.49e-01	0.116000	3.14e-01
Post-translational protein phosphorylation	100	4.62e-02	0.115000	1.34e-01
Metabolism of amine-derived hormones	17	4.12e-01	0.115000	5.87e-01
Interleukin-12 signaling	44	1.88e-01	-0.115000	3.65e-01
Notch-HLH transcription pathway	24	3.31e-01	-0.115000	5.10e-01
Fertilization	26	3.12e-01	0.114000	4.92e-01
Interleukin-17 signaling	66	1.09e-01	-0.114000	2.49e-01
Assembly of collagen fibrils and other multimeric structures	56	1.40e-01	0.114000	2.98e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	3.05e-01	-0.114000	4.87e-01
Metabolism of steroid hormones	33	2.57e-01	0.114000	4.42e-01
Ion channel transport	168	1.11e-02	0.114000	4.70e-02
Metabolic disorders of biological oxidation enzymes	32	2.67e-01	-0.113000	4.53e-01
Vpr-mediated nuclear import of PICs	32	2.69e-01	-0.113000	4.55e-01
Blood group systems biosynthesis	22	3.59e-01	0.113000	5.38e-01
Endogenous sterols	26	3.19e-01	0.113000	4.97e-01
G alpha (q) signalling events	206	5.40e-03	0.112000	2.60e-02
Passive transport by Aquaporins	13	4.83e-01	0.112000	6.54e-01
RND2 GTPase cycle	42	2.08e-01	0.112000	3.86e-01
SARS-CoV-2 modulates autophagy	11	5.19e-01	-0.112000	6.79e-01
Extracellular matrix organization	288	1.04e-03	0.112000	6.82e-03
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	4.54e-01	-0.112000	6.26e-01
Axon guidance	503	1.75e-05	-0.112000	1.89e-04
PIP3 activates AKT signaling	275	1.43e-03	-0.112000	9.04e-03
Transport of the SLBP Dependant Mature mRNA	34	2.60e-01	-0.112000	4.46e-01
Diseases of DNA repair	49	1.77e-01	-0.112000	3.50e-01
Metalloprotease DUBs	19	4.00e-01	-0.111000	5.73e-01
FCERI mediated MAPK activation	29	2.99e-01	-0.111000	4.81e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	3.35e-01	-0.111000	5.13e-01
O-linked glycosylation of mucins	62	1.29e-01	0.111000	2.81e-01
TRAF3-dependent IRF activation pathway	15	4.55e-01	-0.111000	6.28e-01
Signaling by NOTCH1	70	1.08e-01	-0.111000	2.49e-01
Cytosolic sulfonation of small molecules	23	3.58e-01	0.111000	5.38e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	20	3.91e-01	0.111000	5.64e-01
Asparagine N-linked glycosylation	278	1.52e-03	-0.110000	9.50e-03
Nuclear Pore Complex (NPC) Disassembly	34	2.65e-01	-0.110000	4.51e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	3.14e-01	0.110000	4.92e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	3.09e-01	0.109000	4.88e-01
Trafficking of AMPA receptors	29	3.09e-01	0.109000	4.88e-01
G alpha (z) signalling events	48	1.91e-01	0.109000	3.66e-01
GPCR downstream signalling	604	4.56e-06	0.109000	6.01e-05
Defects in cobalamin (B12) metabolism	12	5.16e-01	-0.108000	6.77e-01
Infectious disease	885	4.11e-08	-0.108000	8.84e-07
Signaling by Retinoic Acid	41	2.31e-01	-0.108000	4.13e-01
Signal attenuation	10	5.54e-01	-0.108000	7.05e-01
Viral Messenger RNA Synthesis	42	2.29e-01	-0.107000	4.11e-01
Dissolution of Fibrin Clot	13	5.04e-01	-0.107000	6.70e-01
Nucleotide-like (purinergic) receptors	13	5.04e-01	0.107000	6.70e-01
Nervous system development	527	2.57e-05	-0.107000	2.70e-04
Signaling by Interleukins	426	1.56e-04	-0.107000	1.29e-03
Netrin-1 signaling	49	1.97e-01	0.106000	3.71e-01
GABA receptor activation	57	1.65e-01	0.106000	3.34e-01
mTORC1-mediated signalling	23	3.79e-01	0.106000	5.53e-01
CD28 dependent Vav1 pathway	11	5.44e-01	-0.106000	6.96e-01
Gap junction degradation	10	5.63e-01	0.106000	7.10e-01
Cell surface interactions at the vascular wall	129	3.88e-02	-0.105000	1.19e-01
Signal transduction by L1	20	4.15e-01	0.105000	5.88e-01
Diseases associated with O-glycosylation of proteins	66	1.39e-01	0.105000	2.98e-01
HCMV Late Events	54	1.82e-01	-0.105000	3.57e-01
Synthesis of PIPs at the late endosome membrane	10	5.67e-01	0.105000	7.14e-01
Thrombin signalling through proteinase activated receptors (PARs)	32	3.06e-01	-0.105000	4.88e-01
Regulation of RUNX1 Expression and Activity	25	3.65e-01	-0.105000	5.45e-01
Fatty acyl-CoA biosynthesis	35	2.84e-01	0.104000	4.68e-01
Regulation of IFNA/IFNB signaling	24	3.77e-01	0.104000	5.52e-01
Nuclear Envelope Breakdown	50	2.02e-01	-0.104000	3.77e-01
Inflammasomes	21	4.09e-01	-0.104000	5.83e-01
Phospholipase C-mediated cascade: FGFR1	16	4.73e-01	-0.104000	6.47e-01
Translesion synthesis by REV1	16	4.74e-01	-0.103000	6.47e-01
CDC42 GTPase cycle	144	3.23e-02	0.103000	1.03e-01
Regulation of localization of FOXO transcription factors	11	5.54e-01	0.103000	7.04e-01
Syndecan interactions	19	4.37e-01	-0.103000	6.11e-01
ERBB2 Regulates Cell Motility	15	4.91e-01	0.103000	6.59e-01
Neurexins and neuroligins	52	2.00e-01	0.103000	3.76e-01
Interleukin-1 family signaling	134	4.07e-02	-0.102000	1.22e-01
SARS-CoV-2-host interactions	185	1.64e-02	-0.102000	6.24e-02
Glucagon signaling in metabolic regulation	33	3.12e-01	0.102000	4.92e-01
SUMOylation of intracellular receptors	29	3.46e-01	-0.101000	5.27e-01
Pyroptosis	26	3.73e-01	-0.101000	5.50e-01
RHO GTPases Activate NADPH Oxidases	22	4.15e-01	-0.100000	5.88e-01
Circadian Clock	69	1.51e-01	-0.100000	3.16e-01
Ion transport by P-type ATPases	51	2.17e-01	0.099900	3.99e-01
Negative regulation of FGFR2 signaling	33	3.23e-01	-0.099400	5.00e-01
G alpha (12/13) signalling events	74	1.39e-01	0.099300	2.98e-01
Transport of Mature mRNA Derived from an Intronless Transcript	40	2.77e-01	-0.099200	4.63e-01
CTNNB1 S33 mutants aren’t phosphorylated	14	5.21e-01	-0.099000	6.79e-01
CTNNB1 S37 mutants aren’t phosphorylated	14	5.21e-01	-0.099000	6.79e-01
CTNNB1 S45 mutants aren’t phosphorylated	14	5.21e-01	-0.099000	6.79e-01
CTNNB1 T41 mutants aren’t phosphorylated	14	5.21e-01	-0.099000	6.79e-01
Signaling by CTNNB1 phospho-site mutants	14	5.21e-01	-0.099000	6.79e-01
Signaling by GSK3beta mutants	14	5.21e-01	-0.099000	6.79e-01
RHOBTB GTPase Cycle	34	3.18e-01	-0.099000	4.95e-01
Signaling by NODAL	22	4.22e-01	-0.098900	5.95e-01
Inositol phosphate metabolism	45	2.52e-01	0.098600	4.37e-01
Glycosphingolipid metabolism	40	2.81e-01	-0.098500	4.66e-01
Depolymerisation of the Nuclear Lamina	14	5.24e-01	-0.098400	6.81e-01
Autophagy	125	5.78e-02	-0.098200	1.57e-01
Binding and Uptake of Ligands by Scavenger Receptors	41	2.77e-01	0.098000	4.63e-01
Anchoring of the basal body to the plasma membrane	92	1.05e-01	-0.097700	2.44e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	5.13e-01	-0.097500	6.76e-01
Organelle biogenesis and maintenance	243	8.86e-03	-0.097400	3.92e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	15	5.14e-01	0.097300	6.76e-01
Signaling by PDGFRA extracellular domain mutants	12	5.61e-01	-0.097000	7.08e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	5.61e-01	-0.097000	7.08e-01
Carboxyterminal post-translational modifications of tubulin	40	2.91e-01	-0.096400	4.75e-01
Tight junction interactions	28	3.78e-01	0.096100	5.53e-01
Regulation of gene expression in beta cells	21	4.46e-01	-0.096100	6.18e-01
Anti-inflammatory response favouring Leishmania parasite infection	164	3.38e-02	0.096000	1.07e-01
Leishmania parasite growth and survival	164	3.38e-02	0.096000	1.07e-01
Regulation of innate immune responses to cytosolic DNA	14	5.34e-01	-0.095900	6.89e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	16	5.09e-01	-0.095400	6.73e-01
Transcriptional regulation by small RNAs	46	2.63e-01	-0.095300	4.48e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	4.19e-01	-0.095200	5.92e-01
Neutrophil degranulation	458	4.65e-04	-0.095200	3.42e-03
RHOC GTPase cycle	69	1.72e-01	0.095100	3.44e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	5.24e-01	-0.094900	6.81e-01
Interleukin-35 Signalling	12	5.70e-01	-0.094600	7.18e-01
Platelet degranulation	116	7.88e-02	0.094400	2.01e-01
Keratan sulfate biosynthesis	28	3.88e-01	0.094200	5.60e-01
Signaling by SCF-KIT	43	2.86e-01	-0.094000	4.70e-01
Heme signaling	45	2.76e-01	0.093800	4.62e-01
TAK1-dependent IKK and NF-kappa-B activation	25	4.19e-01	-0.093400	5.92e-01
Scavenging by Class A Receptors	19	4.82e-01	0.093200	6.53e-01
ADORA2B mediated anti-inflammatory cytokines production	132	6.49e-02	0.093000	1.74e-01
Nucleotide biosynthesis	14	5.47e-01	-0.092900	6.98e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	5.50e-01	-0.092200	7.01e-01
Ca-dependent events	35	3.49e-01	0.091500	5.30e-01
Amyloid fiber formation	53	2.50e-01	-0.091300	4.36e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	41	3.12e-01	-0.091200	4.92e-01
Signaling by NOTCH3	48	2.75e-01	-0.091100	4.62e-01
Formation of the Early Elongation Complex	32	3.73e-01	-0.090900	5.50e-01
Formation of the HIV-1 Early Elongation Complex	32	3.73e-01	-0.090900	5.50e-01
RUNX2 regulates osteoblast differentiation	22	4.61e-01	-0.090800	6.34e-01
Miscellaneous substrates	12	5.86e-01	0.090700	7.28e-01
RAC1 GTPase cycle	170	4.33e-02	0.089800	1.27e-01
MAPK family signaling cascades	312	6.40e-03	-0.089600	3.04e-02
tRNA Aminoacylation	24	4.48e-01	-0.089500	6.20e-01
Telomere Maintenance	62	2.26e-01	-0.088900	4.07e-01
Leading Strand Synthesis	13	5.79e-01	-0.088900	7.25e-01
Polymerase switching	13	5.79e-01	-0.088900	7.25e-01
Intracellular signaling by second messengers	313	7.15e-03	-0.088300	3.31e-02
FCGR3A-mediated IL10 synthesis	37	3.53e-01	0.088100	5.35e-01
Budding and maturation of HIV virion	28	4.20e-01	-0.088100	5.93e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	5.83e-01	-0.087900	7.25e-01
Cargo trafficking to the periciliary membrane	49	2.88e-01	-0.087800	4.71e-01
Signaling by Nuclear Receptors	237	1.98e-02	-0.087800	7.09e-02
Synthesis of PIPs at the Golgi membrane	17	5.32e-01	-0.087500	6.88e-01
Formation of the beta-catenin:TCF transactivating complex	32	3.92e-01	-0.087500	5.64e-01
Translesion synthesis by POLK	17	5.33e-01	-0.087200	6.88e-01
Plasma lipoprotein remodeling	32	3.94e-01	0.087000	5.66e-01
Response to elevated platelet cytosolic Ca2+	121	9.81e-02	0.087000	2.35e-01
Interleukin-10 signaling	45	3.13e-01	0.086900	4.92e-01
Glycogen breakdown (glycogenolysis)	12	6.04e-01	-0.086400	7.42e-01
Protein ubiquitination	61	2.44e-01	-0.086100	4.30e-01
Transcriptional regulation of white adipocyte differentiation	81	1.81e-01	-0.085900	3.56e-01
ISG15 antiviral mechanism	71	2.11e-01	-0.085800	3.89e-01
Antiviral mechanism by IFN-stimulated genes	78	1.90e-01	-0.085800	3.65e-01
Glutathione synthesis and recycling	13	5.92e-01	-0.085800	7.33e-01
Ethanol oxidation	12	6.07e-01	0.085700	7.43e-01
MHC class II antigen presentation	104	1.32e-01	-0.085500	2.85e-01
EPH-Ephrin signaling	90	1.61e-01	-0.085500	3.29e-01
PCNA-Dependent Long Patch Base Excision Repair	21	4.99e-01	-0.085200	6.67e-01
Azathioprine ADME	22	4.90e-01	0.085000	6.58e-01
DAG and IP3 signaling	39	3.61e-01	0.084400	5.40e-01
MAPK1/MAPK3 signaling	271	1.66e-02	-0.084400	6.29e-02
Defective B3GAT3 causes JDSSDHD	17	5.47e-01	0.084400	6.98e-01
NOTCH3 Intracellular Domain Regulates Transcription	24	4.75e-01	-0.084200	6.47e-01
RORA activates gene expression	17	5.50e-01	0.083700	7.01e-01
COPI-mediated anterograde transport	83	1.89e-01	-0.083300	3.65e-01
Chromatin modifying enzymes	185	5.07e-02	-0.083200	1.43e-01
Chromatin organization	185	5.07e-02	-0.083200	1.43e-01
Disease	1624	1.85e-08	-0.083200	4.28e-07
Synthesis of IP3 and IP4 in the cytosol	25	4.72e-01	0.083000	6.47e-01
CD28 dependent PI3K/Akt signaling	22	5.02e-01	0.082700	6.69e-01
Cytokine Signaling in Immune system	667	2.59e-04	-0.082700	2.00e-03
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	6.06e-01	0.082500	7.43e-01
Aquaporin-mediated transport	51	3.09e-01	0.082400	4.88e-01
Citric acid cycle (TCA cycle)	21	5.14e-01	-0.082300	6.76e-01
RHOF GTPase cycle	40	3.70e-01	0.081900	5.50e-01
Pregnenolone biosynthesis	10	6.54e-01	-0.081900	7.78e-01
Uptake and actions of bacterial toxins	29	4.46e-01	-0.081800	6.18e-01
RHOH GTPase cycle	36	3.96e-01	-0.081800	5.67e-01
Suppression of phagosomal maturation	13	6.10e-01	-0.081700	7.44e-01
RAF/MAP kinase cascade	265	2.24e-02	-0.081400	7.74e-02
Signaling by BMP	27	4.65e-01	0.081200	6.38e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	120	1.25e-01	-0.081100	2.74e-01
Transport of Ribonucleoproteins into the Host Nucleus	30	4.43e-01	-0.080900	6.15e-01
Activation of GABAB receptors	43	3.59e-01	0.080800	5.38e-01
GABA B receptor activation	43	3.59e-01	0.080800	5.38e-01
Pre-NOTCH Expression and Processing	61	2.75e-01	-0.080700	4.62e-01
Lagging Strand Synthesis	19	5.42e-01	-0.080700	6.94e-01
Cell recruitment (pro-inflammatory response)	25	4.87e-01	-0.080300	6.56e-01
Purinergic signaling in leishmaniasis infection	25	4.87e-01	-0.080300	6.56e-01
Pentose phosphate pathway	12	6.31e-01	0.080100	7.59e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	4.48e-01	-0.080000	6.20e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	4.48e-01	-0.080000	6.20e-01
Keratan sulfate/keratin metabolism	33	4.27e-01	0.079900	6.00e-01
Signaling by ERBB2 TMD/JMD mutants	21	5.26e-01	-0.079900	6.83e-01
Rap1 signalling	16	5.81e-01	-0.079700	7.25e-01
HCMV Early Events	55	3.07e-01	-0.079600	4.88e-01
Golgi-to-ER retrograde transport	115	1.40e-01	-0.079500	2.99e-01
Interleukin receptor SHC signaling	24	5.00e-01	0.079400	6.68e-01
Sphingolipid de novo biosynthesis	41	3.79e-01	0.079400	5.53e-01
Antigen processing: Ubiquitination & Proteasome degradation	293	1.98e-02	-0.079000	7.09e-02
SHC1 events in EGFR signaling	14	6.09e-01	-0.078900	7.44e-01
Triglyceride catabolism	23	5.13e-01	0.078900	6.76e-01
PIWI-interacting RNA (piRNA) biogenesis	29	4.63e-01	0.078800	6.35e-01
HCMV Infection	79	2.28e-01	-0.078500	4.09e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	3.85e-01	-0.078400	5.57e-01
Signaling by RAS mutants	41	3.85e-01	-0.078400	5.57e-01
Signaling by moderate kinase activity BRAF mutants	41	3.85e-01	-0.078400	5.57e-01
Signaling downstream of RAS mutants	41	3.85e-01	-0.078400	5.57e-01
Class A/1 (Rhodopsin-like receptors)	312	1.72e-02	0.078300	6.43e-02
Sodium/Calcium exchangers	11	6.53e-01	0.078300	7.78e-01
Signaling by Non-Receptor Tyrosine Kinases	55	3.18e-01	-0.077900	4.95e-01
Signaling by PTK6	55	3.18e-01	-0.077900	4.95e-01
Initial triggering of complement	21	5.37e-01	0.077800	6.91e-01
Uptake and function of anthrax toxins	11	6.55e-01	-0.077800	7.79e-01
CTLA4 inhibitory signaling	21	5.37e-01	0.077800	6.91e-01
Nucleotide catabolism	35	4.26e-01	0.077700	6.00e-01
Amino acids regulate mTORC1	52	3.34e-01	-0.077400	5.13e-01
Post-translational protein modification	1294	2.69e-06	-0.077200	3.81e-05
TRAF6 mediated IRF7 activation	28	4.80e-01	0.077100	6.52e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	117	1.50e-01	0.077000	3.14e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	13	6.31e-01	-0.077000	7.59e-01
Peptide ligand-binding receptors	190	6.71e-02	0.076900	1.78e-01
DNA Damage Bypass	46	3.70e-01	-0.076400	5.50e-01
ER to Golgi Anterograde Transport	134	1.31e-01	-0.075400	2.85e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	5.33e-01	-0.075100	6.88e-01
Platelet sensitization by LDL	17	5.92e-01	-0.075000	7.33e-01
Class I MHC mediated antigen processing & presentation	363	1.41e-02	-0.074900	5.55e-02
LDL clearance	19	5.72e-01	-0.074900	7.19e-01
Downregulation of ERBB2 signaling	28	4.93e-01	-0.074800	6.61e-01
Signaling by FGFR4 in disease	11	6.67e-01	-0.074800	7.89e-01
Regulation of actin dynamics for phagocytic cup formation	59	3.22e-01	-0.074600	4.99e-01
Norepinephrine Neurotransmitter Release Cycle	16	6.06e-01	0.074500	7.43e-01
Meiosis	56	3.38e-01	-0.074000	5.16e-01
Signaling by ERBB2	49	3.70e-01	-0.074000	5.50e-01
Cytochrome P450 - arranged by substrate type	64	3.06e-01	0.073900	4.88e-01
Thromboxane signalling through TP receptor	24	5.32e-01	-0.073600	6.88e-01
Hyaluronan metabolism	17	6.00e-01	-0.073500	7.38e-01
HATs acetylate histones	71	2.86e-01	-0.073200	4.70e-01
Signaling by GPCR	671	1.21e-03	0.073000	7.82e-03
G alpha (s) signalling events	153	1.20e-01	0.072700	2.67e-01
Serotonin Neurotransmitter Release Cycle	16	6.15e-01	0.072600	7.48e-01
Frs2-mediated activation	12	6.63e-01	-0.072600	7.86e-01
Fatty acids	15	6.26e-01	-0.072600	7.56e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	6.15e-01	-0.072500	7.48e-01
Elevation of cytosolic Ca2+ levels	16	6.16e-01	-0.072500	7.48e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	6.64e-01	0.072400	7.86e-01
Regulated proteolysis of p75NTR	11	6.79e-01	-0.072100	7.98e-01
The role of Nef in HIV-1 replication and disease pathogenesis	27	5.17e-01	0.072100	6.78e-01
CaMK IV-mediated phosphorylation of CREB	10	6.94e-01	-0.071900	8.10e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	181	9.69e-02	-0.071500	2.35e-01
Negative regulation of MET activity	20	5.81e-01	0.071300	7.25e-01
PKA-mediated phosphorylation of CREB	19	5.90e-01	0.071300	7.32e-01
Chylomicron remodeling	10	6.96e-01	-0.071200	8.12e-01
Interleukin-6 signaling	11	6.83e-01	-0.071100	7.99e-01
Diseases of signal transduction by growth factor receptors and second messengers	410	1.35e-02	-0.071000	5.39e-02
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	6.72e-01	-0.070600	7.93e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	4.53e-01	-0.070200	6.26e-01
Laminin interactions	23	5.60e-01	0.070200	7.08e-01
GPCR ligand binding	444	1.11e-02	0.070100	4.71e-02
Clathrin-mediated endocytosis	135	1.60e-01	-0.069900	3.28e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	6.52e-01	-0.069600	7.77e-01
Cilium Assembly	174	1.15e-01	-0.069200	2.58e-01
RND1 GTPase cycle	41	4.43e-01	0.069200	6.15e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	31	5.06e-01	-0.069000	6.71e-01
Chondroitin sulfate/dermatan sulfate metabolism	45	4.27e-01	-0.068400	6.00e-01
Glucocorticoid biosynthesis	10	7.09e-01	0.068300	8.18e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	101	2.36e-01	0.068200	4.21e-01
Nicotinamide salvaging	17	6.30e-01	-0.067500	7.59e-01
Extra-nuclear estrogen signaling	73	3.22e-01	-0.067000	4.99e-01
Adaptive Immune System	711	2.28e-03	-0.067000	1.31e-02
Role of phospholipids in phagocytosis	23	5.78e-01	0.066900	7.25e-01
Insulin processing	26	5.55e-01	-0.066900	7.05e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	7.01e-01	-0.066700	8.14e-01
Digestion of dietary carbohydrate	10	7.17e-01	0.066100	8.23e-01
FRS-mediated FGFR3 signaling	19	6.18e-01	-0.066100	7.49e-01
Signaling by FGFR in disease	61	3.73e-01	-0.065900	5.50e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77	3.17e-01	-0.065900	4.95e-01
RUNX2 regulates bone development	29	5.39e-01	-0.065900	6.92e-01
EPHB-mediated forward signaling	34	5.07e-01	-0.065800	6.71e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37	4.89e-01	-0.065600	6.58e-01
Vasopressin regulates renal water homeostasis via Aquaporins	42	4.63e-01	0.065500	6.35e-01
Chromosome Maintenance	86	2.94e-01	-0.065400	4.77e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	27	5.58e-01	0.065200	7.06e-01
Regulation of MECP2 expression and activity	30	5.41e-01	-0.064500	6.93e-01
Acetylcholine Neurotransmitter Release Cycle	16	6.56e-01	0.064300	7.79e-01
Activation of BH3-only proteins	30	5.42e-01	-0.064300	6.94e-01
FRS-mediated FGFR4 signaling	21	6.10e-01	-0.064200	7.44e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	5.79e-01	-0.064000	7.25e-01
Disorders of transmembrane transporters	167	1.53e-01	-0.064000	3.18e-01
Transcriptional regulation of testis differentiation	12	7.01e-01	0.064000	8.14e-01
Constitutive Signaling by Aberrant PI3K in Cancer	77	3.33e-01	0.063800	5.11e-01
NOTCH2 intracellular domain regulates transcription	11	7.15e-01	-0.063500	8.22e-01
HDMs demethylate histones	18	6.44e-01	-0.062900	7.73e-01
Muscle contraction	186	1.39e-01	0.062800	2.98e-01
Integrin cell surface interactions	66	3.77e-01	0.062800	5.52e-01
PKA activation	18	6.47e-01	0.062400	7.74e-01
Vitamin D (calciferol) metabolism	12	7.09e-01	-0.062200	8.18e-01
Smooth Muscle Contraction	39	5.02e-01	0.062100	6.69e-01
Activation of Matrix Metalloproteinases	31	5.50e-01	0.062000	7.01e-01
Glutamate Neurotransmitter Release Cycle	23	6.08e-01	-0.061700	7.44e-01
MET receptor recycling	10	7.36e-01	0.061700	8.34e-01
Ras activation upon Ca2+ influx through NMDA receptor	19	6.42e-01	-0.061600	7.71e-01
Biotin transport and metabolism	10	7.36e-01	0.061600	8.34e-01
MAP2K and MAPK activation	36	5.24e-01	-0.061400	6.81e-01
Synthesis of PIPs at the early endosome membrane	15	6.81e-01	0.061300	7.99e-01
Protein-protein interactions at synapses	78	3.50e-01	0.061200	5.30e-01
Inwardly rectifying K+ channels	35	5.32e-01	0.061100	6.88e-01
Signaling by Insulin receptor	76	3.58e-01	-0.060900	5.38e-01
Listeria monocytogenes entry into host cells	19	6.49e-01	0.060300	7.75e-01
FGFR3 ligand binding and activation	12	7.18e-01	-0.060200	8.23e-01
FGFR3c ligand binding and activation	12	7.18e-01	-0.060200	8.23e-01
Interleukin-20 family signaling	25	6.06e-01	-0.059500	7.43e-01
Protein methylation	16	6.81e-01	-0.059300	7.99e-01
Cargo recognition for clathrin-mediated endocytosis	98	3.10e-01	-0.059300	4.90e-01
Signaling by BRAF and RAF1 fusions	60	4.31e-01	0.058700	6.06e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	38	5.33e-01	-0.058500	6.88e-01
Platelet calcium homeostasis	27	5.99e-01	-0.058400	7.38e-01
Extension of Telomeres	48	4.85e-01	-0.058200	6.55e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	4.74e-01	-0.057900	6.47e-01
FGFR2c ligand binding and activation	12	7.30e-01	0.057400	8.31e-01
Meiotic recombination	26	6.13e-01	-0.057400	7.46e-01
Signaling by ERBB4	57	4.54e-01	-0.057300	6.26e-01
TNFR1-induced NFkappaB signaling pathway	22	6.42e-01	-0.057200	7.72e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	42	5.21e-01	0.057200	6.79e-01
Cardiac conduction	120	2.82e-01	0.056900	4.66e-01
Regulation of PTEN mRNA translation	25	6.23e-01	-0.056700	7.53e-01
Neurotransmitter receptors and postsynaptic signal transmission	175	1.96e-01	0.056600	3.70e-01
CD28 co-stimulation	32	5.80e-01	0.056600	7.25e-01
Metabolism	1967	3.19e-05	-0.056300	3.21e-04
G beta:gamma signalling through CDC42	19	6.72e-01	-0.056100	7.93e-01
DSCAM interactions	11	7.47e-01	0.056100	8.43e-01
Termination of translesion DNA synthesis	31	5.89e-01	-0.056100	7.31e-01
Late endosomal microautophagy	32	5.84e-01	-0.055900	7.26e-01
Retinoid metabolism and transport	42	5.35e-01	0.055300	6.90e-01
Death Receptor Signalling	129	2.82e-01	-0.054800	4.66e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	7.24e-01	-0.054500	8.25e-01
Sema3A PAK dependent Axon repulsion	14	7.24e-01	0.054400	8.25e-01
FGFR2 mutant receptor activation	32	5.95e-01	-0.054300	7.35e-01
Aflatoxin activation and detoxification	20	6.76e-01	0.054000	7.96e-01
Incretin synthesis, secretion, and inactivation	23	6.54e-01	-0.053900	7.78e-01
SLC-mediated transmembrane transport	238	1.52e-01	0.053900	3.17e-01
CaM pathway	33	5.94e-01	0.053500	7.34e-01
Calmodulin induced events	33	5.94e-01	0.053500	7.34e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	7.03e-01	0.053300	8.15e-01
Diseases associated with the TLR signaling cascade	29	6.19e-01	-0.053300	7.49e-01
Diseases of Immune System	29	6.19e-01	-0.053300	7.49e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	6.21e-01	0.053100	7.50e-01
Rab regulation of trafficking	114	3.28e-01	-0.053000	5.07e-01
Signaling by FGFR1 in disease	37	5.79e-01	-0.052700	7.25e-01
Kinesins	42	5.56e-01	0.052500	7.05e-01
Interleukin-37 signaling	21	6.77e-01	0.052500	7.97e-01
Eicosanoid ligand-binding receptors	14	7.36e-01	0.052100	8.34e-01
Hyaluronan uptake and degradation	12	7.55e-01	-0.051900	8.50e-01
Tie2 Signaling	18	7.03e-01	-0.051900	8.15e-01
Intra-Golgi traffic	43	5.56e-01	-0.051900	7.05e-01
SHC1 events in ERBB2 signaling	22	6.74e-01	-0.051800	7.94e-01
PI3K Cascade	43	5.60e-01	0.051400	7.08e-01
Vitamin B5 (pantothenate) metabolism	16	7.22e-01	0.051300	8.25e-01
Assembly and cell surface presentation of NMDA receptors	23	6.72e-01	-0.050900	7.93e-01
NS1 Mediated Effects on Host Pathways	39	5.83e-01	-0.050800	7.25e-01
Phase I - Functionalization of compounds	100	3.81e-01	0.050700	5.54e-01
FOXO-mediated transcription	65	4.80e-01	-0.050600	6.52e-01
Transport to the Golgi and subsequent modification	165	2.63e-01	-0.050400	4.48e-01
Innate Immune System	999	6.79e-03	-0.050400	3.18e-02
Sialic acid metabolism	33	6.18e-01	-0.050200	7.49e-01
Opioid Signalling	88	4.16e-01	0.050100	5.90e-01
Signaling by FGFR2 IIIa TM	19	7.07e-01	-0.049800	8.17e-01
Defective GALNT3 causes HFTC	18	7.14e-01	0.049800	8.21e-01
trans-Golgi Network Vesicle Budding	67	4.82e-01	-0.049700	6.53e-01
Mitotic Telophase/Cytokinesis	10	7.86e-01	-0.049500	8.75e-01
Transmission across Chemical Synapses	237	1.90e-01	0.049300	3.65e-01
Diseases associated with glycosaminoglycan metabolism	38	5.99e-01	0.049300	7.38e-01
DAP12 interactions	40	5.92e-01	0.049000	7.33e-01
Carnitine metabolism	11	7.78e-01	0.049000	8.69e-01
Factors involved in megakaryocyte development and platelet production	130	3.41e-01	0.048300	5.20e-01
Pre-NOTCH Transcription and Translation	45	5.76e-01	-0.048200	7.23e-01
Cell death signalling via NRAGE, NRIF and NADE	69	4.89e-01	0.048200	6.58e-01
Triglyceride metabolism	36	6.18e-01	0.048000	7.49e-01
Constitutive Signaling by EGFRvIII	15	7.48e-01	-0.048000	8.43e-01
Signaling by EGFRvIII in Cancer	15	7.48e-01	-0.048000	8.43e-01
Arachidonic acid metabolism	56	5.37e-01	0.047600	6.91e-01
Amine ligand-binding receptors	41	5.99e-01	0.047500	7.38e-01
Downstream signaling of activated FGFR1	31	6.49e-01	-0.047300	7.75e-01
Costimulation by the CD28 family	65	5.11e-01	-0.047100	6.75e-01
Transport of vitamins, nucleosides, and related molecules	38	6.17e-01	0.046900	7.49e-01
Signaling by FGFR2 in disease	42	6.02e-01	-0.046400	7.41e-01
Amino acid transport across the plasma membrane	30	6.63e-01	-0.046000	7.86e-01
Transcriptional Regulation by MECP2	60	5.39e-01	-0.045900	6.92e-01
Dermatan sulfate biosynthesis	10	8.03e-01	0.045600	8.85e-01
RHOG GTPase cycle	69	5.15e-01	0.045300	6.77e-01
Immune System	1877	1.08e-03	-0.045200	7.02e-03
FRS-mediated FGFR2 signaling	24	7.02e-01	-0.045000	8.15e-01
Cellular hexose transport	21	7.21e-01	0.044900	8.24e-01
Signaling by Receptor Tyrosine Kinases	492	8.73e-02	-0.044900	2.17e-01
G beta:gamma signalling through PI3Kgamma	25	6.98e-01	-0.044700	8.13e-01
RHOA GTPase cycle	140	3.62e-01	0.044600	5.41e-01
Signaling by ERBB2 in Cancer	25	7.01e-01	-0.044400	8.14e-01
RAC3 GTPase cycle	84	4.85e-01	-0.044100	6.55e-01
Interferon Signaling	194	2.90e-01	-0.044000	4.74e-01
NCAM1 interactions	36	6.48e-01	0.044000	7.74e-01
Regulation of insulin secretion	77	5.05e-01	0.044000	6.70e-01
Nicotinate metabolism	29	6.82e-01	-0.043900	7.99e-01
Activation of G protein gated Potassium channels	29	6.84e-01	0.043700	7.99e-01
G protein gated Potassium channels	29	6.84e-01	0.043700	7.99e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	29	6.84e-01	0.043700	7.99e-01
Mitochondrial Fatty Acid Beta-Oxidation	35	6.57e-01	-0.043400	7.80e-01
SLC transporter disorders	92	4.76e-01	0.043000	6.48e-01
Repression of WNT target genes	13	7.89e-01	-0.042900	8.75e-01
DARPP-32 events	24	7.20e-01	-0.042200	8.24e-01
Diseases of metabolism	234	2.70e-01	-0.041800	4.57e-01
The NLRP3 inflammasome	16	7.75e-01	-0.041200	8.66e-01
Signaling by PDGF	52	6.08e-01	0.041100	7.44e-01
G beta:gamma signalling through BTK	17	7.70e-01	-0.041000	8.61e-01
Developmental Biology	1020	2.61e-02	-0.041000	8.74e-02
Transport of bile salts and organic acids, metal ions and amine compounds	84	5.16e-01	0.040900	6.78e-01
Metabolism of vitamins and cofactors	181	3.46e-01	-0.040600	5.26e-01
mRNA Editing	10	8.27e-01	-0.040000	9.00e-01
Metabolism of carbohydrates	275	2.54e-01	-0.039900	4.39e-01
Organic anion transporters	10	8.28e-01	0.039700	9.00e-01
GRB2 events in ERBB2 signaling	16	7.84e-01	-0.039500	8.74e-01
Striated Muscle Contraction	33	6.95e-01	-0.039400	8.11e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	112	4.74e-01	0.039200	6.47e-01
GPVI-mediated activation cascade	32	7.01e-01	-0.039200	8.14e-01
Platelet homeostasis	85	5.33e-01	0.039100	6.88e-01
Negative regulation of the PI3K/AKT network	111	4.80e-01	0.038800	6.52e-01
Telomere C-strand (Lagging Strand) Synthesis	32	7.05e-01	-0.038700	8.16e-01
Signaling by Rho GTPases	590	1.08e-01	-0.038600	2.49e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	7.68e-01	-0.038100	8.61e-01
RHOD GTPase cycle	49	6.45e-01	0.038000	7.74e-01
Reduction of cytosolic Ca++ levels	11	8.27e-01	-0.038000	9.00e-01
Leishmania infection	245	3.07e-01	0.037800	4.88e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	604	1.13e-01	-0.037600	2.56e-01
Adrenaline,noradrenaline inhibits insulin secretion	28	7.30e-01	-0.037600	8.31e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	7.47e-01	-0.037300	8.43e-01
RHOBTB2 GTPase cycle	22	7.62e-01	-0.037300	8.56e-01
Gastrin-CREB signalling pathway via PKC and MAPK	17	7.90e-01	-0.037200	8.75e-01
PI-3K cascade:FGFR1	21	7.69e-01	0.037000	8.61e-01
Integration of energy metabolism	106	5.11e-01	0.036900	6.75e-01
Organic cation transport	10	8.40e-01	0.036900	9.08e-01
Biosynthesis of specialized proresolving mediators (SPMs)	19	7.83e-01	0.036400	8.74e-01
DAP12 signaling	28	7.39e-01	0.036400	8.36e-01
NCAM signaling for neurite out-growth	57	6.41e-01	0.035700	7.71e-01
Activated NOTCH1 Transmits Signal to the Nucleus	31	7.32e-01	-0.035500	8.32e-01
RHOV GTPase cycle	36	7.12e-01	-0.035500	8.20e-01
EGFR downregulation	30	7.37e-01	-0.035500	8.34e-01
Phenylalanine and tyrosine metabolism	10	8.47e-01	-0.035300	9.11e-01
Neuronal System	371	2.44e-01	0.035200	4.30e-01
Retrograde transport at the Trans-Golgi-Network	47	6.81e-01	-0.034600	7.99e-01
WNT5A-dependent internalization of FZD4	15	8.17e-01	-0.034500	8.98e-01
Signaling by PDGFR in disease	20	7.90e-01	-0.034400	8.75e-01
Polymerase switching on the C-strand of the telomere	24	7.72e-01	-0.034100	8.63e-01
Peroxisomal lipid metabolism	28	7.56e-01	-0.033900	8.50e-01
Ca2+ pathway	62	6.47e-01	0.033600	7.74e-01
Ephrin signaling	17	8.12e-01	0.033300	8.94e-01
Metabolism of steroids	148	4.84e-01	0.033300	6.55e-01
E3 ubiquitin ligases ubiquitinate target proteins	43	7.06e-01	-0.033200	8.16e-01
Apoptotic execution phase	43	7.11e-01	-0.032600	8.20e-01
Signal Transduction	2408	8.22e-03	-0.032600	3.71e-02
Surfactant metabolism	29	7.61e-01	0.032600	8.55e-01
Regulation of TP53 Activity through Association with Co-factors	14	8.34e-01	-0.032400	9.03e-01
TRP channels	24	7.84e-01	0.032300	8.74e-01
MyD88 deficiency (TLR2/4)	16	8.25e-01	-0.031900	9.00e-01
Regulation of TLR by endogenous ligand	17	8.20e-01	0.031800	9.00e-01
PPARA activates gene expression	114	5.58e-01	0.031700	7.07e-01
Plasma lipoprotein assembly	19	8.11e-01	0.031600	8.94e-01
GRB2 events in EGFR signaling	13	8.44e-01	-0.031500	9.09e-01
Membrane Trafficking	586	1.94e-01	-0.031300	3.69e-01
PI3K/AKT Signaling in Cancer	103	5.83e-01	0.031300	7.25e-01
Presynaptic depolarization and calcium channel opening	12	8.53e-01	0.030900	9.14e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	23	7.99e-01	-0.030700	8.82e-01
Dopamine Neurotransmitter Release Cycle	20	8.16e-01	0.030000	8.98e-01
FCERI mediated Ca+2 mobilization	27	7.88e-01	-0.029800	8.75e-01
Erythrocytes take up carbon dioxide and release oxygen	12	8.59e-01	0.029700	9.17e-01
O2/CO2 exchange in erythrocytes	12	8.59e-01	0.029700	9.17e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	8.53e-01	0.029600	9.14e-01
Prostacyclin signalling through prostacyclin receptor	19	8.23e-01	-0.029600	9.00e-01
Fatty acid metabolism	167	5.10e-01	0.029500	6.75e-01
FGFR2 ligand binding and activation	19	8.25e-01	-0.029400	9.00e-01
Beta-oxidation of very long chain fatty acids	10	8.72e-01	-0.029300	9.25e-01
Metabolism of water-soluble vitamins and cofactors	118	5.83e-01	-0.029200	7.25e-01
COPI-independent Golgi-to-ER retrograde traffic	34	7.68e-01	0.029200	8.61e-01
Heparan sulfate/heparin (HS-GAG) metabolism	49	7.24e-01	0.029100	8.25e-01
GPER1 signaling	44	7.42e-01	0.028700	8.39e-01
EPH-ephrin mediated repulsion of cells	48	7.36e-01	-0.028100	8.34e-01
Phospholipase C-mediated cascade; FGFR2	17	8.44e-01	0.027600	9.09e-01
Transport of small molecules	689	2.21e-01	0.027300	4.03e-01
G-protein beta:gamma signalling	30	7.96e-01	-0.027300	8.79e-01
Biosynthesis of DHA-derived SPMs	17	8.47e-01	0.027000	9.11e-01
Post-translational modification: synthesis of GPI-anchored proteins	90	6.62e-01	0.026700	7.85e-01
Biological oxidations	216	5.00e-01	0.026600	6.68e-01
Signaling by VEGF	101	6.47e-01	0.026400	7.74e-01
Detoxification of Reactive Oxygen Species	35	7.90e-01	0.026000	8.75e-01
Metabolism of lipids	696	2.49e-01	0.025600	4.35e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	20	8.44e-01	-0.025400	9.09e-01
Platelet Aggregation (Plug Formation)	37	7.90e-01	-0.025300	8.75e-01
Cell-extracellular matrix interactions	14	8.71e-01	-0.025100	9.24e-01
Plasma lipoprotein assembly, remodeling, and clearance	73	7.12e-01	-0.025000	8.20e-01
A tetrasaccharide linker sequence is required for GAG synthesis	23	8.38e-01	-0.024500	9.07e-01
Phospholipase C-mediated cascade; FGFR3	12	8.83e-01	0.024500	9.31e-01
Termination of O-glycan biosynthesis	25	8.34e-01	0.024200	9.03e-01
FGFR1 mutant receptor activation	30	8.20e-01	-0.024000	9.00e-01
RAC2 GTPase cycle	80	7.14e-01	0.023700	8.21e-01
Mismatch Repair	15	8.74e-01	-0.023700	9.26e-01
Metabolism of porphyrins	27	8.36e-01	0.023000	9.05e-01
E2F mediated regulation of DNA replication	20	8.60e-01	-0.022800	9.18e-01
Retrograde neurotrophin signalling	14	8.84e-01	0.022500	9.31e-01
Chondroitin sulfate biosynthesis	18	8.69e-01	0.022400	9.23e-01
Glycosaminoglycan metabolism	116	6.79e-01	0.022200	7.98e-01
MTOR signalling	40	8.12e-01	0.021800	8.94e-01
N-Glycan antennae elongation	15	8.84e-01	0.021700	9.31e-01
Signaling by high-kinase activity BRAF mutants	32	8.32e-01	-0.021700	9.03e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	8.89e-01	0.021500	9.35e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	52	7.89e-01	-0.021500	8.75e-01
Vesicle-mediated transport	624	3.59e-01	-0.021400	5.38e-01
Defects in vitamin and cofactor metabolism	20	8.68e-01	-0.021400	9.23e-01
Deposition of new CENPA-containing nucleosomes at the centromere	26	8.55e-01	-0.020700	9.15e-01
Nucleosome assembly	26	8.55e-01	-0.020700	9.15e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	104	7.21e-01	0.020300	8.24e-01
Interferon gamma signaling	90	7.40e-01	0.020200	8.37e-01
RAB GEFs exchange GTP for GDP on RABs	83	7.52e-01	0.020100	8.47e-01
Presynaptic function of Kainate receptors	21	8.75e-01	-0.019800	9.26e-01
ADP signalling through P2Y purinoceptor 1	25	8.64e-01	0.019800	9.20e-01
RHO GTPase cycle	421	4.92e-01	0.019500	6.59e-01
Calcitonin-like ligand receptors	10	9.15e-01	0.019500	9.49e-01
Regulation of lipid metabolism by PPARalpha	116	7.19e-01	0.019300	8.24e-01
PKMTs methylate histone lysines	37	8.42e-01	-0.019000	9.08e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	9.10e-01	-0.018900	9.48e-01
alpha-linolenic acid (ALA) metabolism	12	9.10e-01	-0.018900	9.48e-01
Interconversion of nucleotide di- and triphosphates	29	8.62e-01	-0.018700	9.19e-01
Regulation of KIT signaling	16	8.97e-01	-0.018600	9.40e-01
Activated point mutants of FGFR2	16	8.99e-01	0.018300	9.40e-01
Integrin signaling	27	8.69e-01	-0.018300	9.23e-01
Defective B4GALT7 causes EDS, progeroid type	17	8.97e-01	0.018100	9.40e-01
Signaling by WNT in cancer	32	8.62e-01	0.017700	9.19e-01
Organic cation/anion/zwitterion transport	15	9.07e-01	-0.017300	9.47e-01
FCGR3A-mediated phagocytosis	57	8.24e-01	-0.017100	9.00e-01
Leishmania phagocytosis	57	8.24e-01	-0.017100	9.00e-01
Parasite infection	57	8.24e-01	-0.017100	9.00e-01
MicroRNA (miRNA) biogenesis	26	8.82e-01	-0.016900	9.31e-01
Peptide hormone metabolism	83	7.93e-01	0.016600	8.78e-01
FGFR2b ligand binding and activation	10	9.28e-01	-0.016600	9.54e-01
Elastic fibre formation	41	8.57e-01	-0.016300	9.16e-01
Nucleotide salvage	21	8.99e-01	-0.016100	9.40e-01
Energy dependent regulation of mTOR by LKB1-AMPK	28	8.83e-01	-0.016000	9.31e-01
Neurotransmitter release cycle	47	8.51e-01	-0.015900	9.13e-01
Interferon alpha/beta signaling	71	8.19e-01	0.015700	9.00e-01
IGF1R signaling cascade	51	8.48e-01	-0.015500	9.11e-01
Post NMDA receptor activation events	58	8.41e-01	0.015200	9.08e-01
Insulin receptor signalling cascade	53	8.49e-01	-0.015100	9.12e-01
CS/DS degradation	12	9.29e-01	-0.014900	9.54e-01
Metabolism of fat-soluble vitamins	46	8.65e-01	0.014500	9.20e-01
CD209 (DC-SIGN) signaling	20	9.11e-01	0.014400	9.48e-01
Signaling by NTRK2 (TRKB)	25	9.01e-01	-0.014400	9.41e-01
Phospholipase C-mediated cascade; FGFR4	14	9.26e-01	0.014300	9.54e-01
RND3 GTPase cycle	41	8.74e-01	0.014300	9.26e-01
Reproduction	82	8.24e-01	-0.014200	9.00e-01
RHO GTPases activate PAKs	19	9.16e-01	-0.014000	9.49e-01
Glycerophospholipid biosynthesis	114	7.96e-01	0.014000	8.79e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21	9.13e-01	0.013800	9.48e-01
Gene Silencing by RNA	80	8.32e-01	-0.013700	9.03e-01
RA biosynthesis pathway	22	9.12e-01	-0.013500	9.48e-01
VEGFA-VEGFR2 Pathway	93	8.30e-01	0.012900	9.02e-01
RET signaling	41	8.91e-01	0.012300	9.37e-01
Prolonged ERK activation events	14	9.37e-01	-0.012200	9.61e-01
Ion homeostasis	50	8.82e-01	-0.012200	9.31e-01
Downstream signaling of activated FGFR4	26	9.16e-01	-0.011900	9.49e-01
IRS-mediated signalling	47	8.89e-01	-0.011800	9.35e-01
Voltage gated Potassium channels	42	8.95e-01	-0.011800	9.39e-01
Miscellaneous transport and binding events	21	9.27e-01	-0.011500	9.54e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	8.99e-01	0.011400	9.40e-01
Signaling by MET	66	8.75e-01	-0.011200	9.26e-01
Platelet activation, signaling and aggregation	246	7.63e-01	0.011200	8.56e-01
Signaling by EGFR	49	8.93e-01	-0.011100	9.38e-01
Activation of kainate receptors upon glutamate binding	29	9.19e-01	0.010900	9.50e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	10	9.53e-01	0.010900	9.70e-01
Apoptotic cleavage of cellular proteins	35	9.12e-01	0.010800	9.48e-01
FGFR3 mutant receptor activation	11	9.51e-01	0.010800	9.70e-01
Signaling by activated point mutants of FGFR3	11	9.51e-01	0.010800	9.70e-01
Diseases of glycosylation	137	8.28e-01	0.010700	9.00e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	9.18e-01	0.010200	9.50e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	9.52e-01	-0.009740	9.70e-01
Glucagon-type ligand receptors	33	9.23e-01	0.009700	9.52e-01
CLEC7A (Dectin-1) induces NFAT activation	11	9.56e-01	-0.009700	9.71e-01
Interleukin-2 family signaling	40	9.16e-01	-0.009580	9.49e-01
Intraflagellar transport	36	9.23e-01	-0.009280	9.52e-01
InlB-mediated entry of Listeria monocytogenes into host cell	14	9.52e-01	-0.009270	9.70e-01
Downstream signaling of activated FGFR3	24	9.39e-01	-0.009030	9.63e-01
Phospholipid metabolism	192	8.34e-01	0.008760	9.03e-01
FGFR1c ligand binding and activation	11	9.60e-01	0.008690	9.74e-01
Signaling by activated point mutants of FGFR1	11	9.60e-01	0.008690	9.74e-01
Sphingolipid metabolism	81	8.95e-01	-0.008480	9.39e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	9.49e-01	-0.008340	9.69e-01
Activation of NMDA receptors and postsynaptic events	69	9.12e-01	0.007690	9.48e-01
Signaling by ALK fusions and activated point mutants	51	9.28e-01	0.007330	9.54e-01
Signaling by ALK in cancer	51	9.28e-01	0.007330	9.54e-01
Molecules associated with elastic fibres	30	9.47e-01	-0.006950	9.69e-01
G-protein activation	24	9.54e-01	-0.006840	9.70e-01
Signaling by cytosolic FGFR1 fusion mutants	17	9.61e-01	0.006830	9.74e-01
PI Metabolism	79	9.18e-01	0.006680	9.50e-01
Purine catabolism	17	9.62e-01	-0.006640	9.74e-01
Triglyceride biosynthesis	13	9.67e-01	-0.006620	9.78e-01
TNFs bind their physiological receptors	25	9.58e-01	0.006030	9.73e-01
Eicosanoids	12	9.71e-01	-0.006010	9.80e-01
p75 NTR receptor-mediated signalling	89	9.22e-01	0.006010	9.52e-01
Fcgamma receptor (FCGR) dependent phagocytosis	82	9.28e-01	0.005770	9.54e-01
ABC transporters in lipid homeostasis	17	9.67e-01	0.005710	9.78e-01
Golgi Associated Vesicle Biogenesis	51	9.46e-01	0.005480	9.69e-01
Signal amplification	33	9.57e-01	-0.005420	9.72e-01
Hemostasis	560	8.27e-01	-0.005390	9.00e-01
Signaling by ERBB2 KD Mutants	24	9.66e-01	-0.004970	9.78e-01
Semaphorin interactions	61	9.48e-01	0.004840	9.69e-01
Signaling by FGFR3 in disease	21	9.71e-01	-0.004510	9.80e-01
Oncogenic MAPK signaling	76	9.52e-01	0.004020	9.70e-01
Effects of PIP2 hydrolysis	26	9.72e-01	0.003910	9.81e-01
Phase II - Conjugation of compounds	109	9.46e-01	-0.003760	9.69e-01
FCGR activation	12	9.83e-01	-0.003610	9.87e-01
Signaling by RAF1 mutants	37	9.73e-01	-0.003220	9.81e-01
IRAK4 deficiency (TLR2/4)	17	9.83e-01	-0.002990	9.87e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27	9.80e-01	0.002760	9.87e-01
FGFR4 ligand binding and activation	13	9.90e-01	0.001950	9.92e-01
IRS-related events triggered by IGF1R	50	9.81e-01	-0.001940	9.87e-01
ADP signalling through P2Y purinoceptor 12	22	9.88e-01	0.001860	9.91e-01
Metabolism of nucleotides	95	9.77e-01	-0.001730	9.84e-01
Nuclear signaling by ERBB4	32	9.87e-01	0.001660	9.91e-01
Downstream signaling of activated FGFR2	29	9.89e-01	-0.001450	9.91e-01
G beta:gamma signalling through PLC beta	20	9.91e-01	-0.001390	9.92e-01
Potassium Channels	102	9.90e-01	-0.000750	9.91e-01
HDL remodeling	10	1.00e+00	-0.000023	1.00e+00

---

Detailed Gene set reports

Constitutive Signaling by Overexpressed ERBB2

Constitutive Signaling by Overexpressed ERBB2

	236
set	Constitutive Signaling by Overexpressed ERBB2
setSize	10
pANOVA	0.000591
s.dist	-0.627
p.adjustANOVA	0.00416

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PTPN12	-13781
HRAS	-13113
NRAS	-12748
KRAS	-12378
ERBB2	-11504
HSP90AA1	-10935
SHC1	-9916
CDC37	-6532
SOS1	-1197
GRB2	1727

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PTPN12	-13781
HRAS	-13113
NRAS	-12748
KRAS	-12378
ERBB2	-11504
HSP90AA1	-10935
SHC1	-9916
CDC37	-6532
SOS1	-1197
GRB2	1727

---

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

	1333
set	Synthesis of bile acids and bile salts via 27-hydroxycholesterol
setSize	15
pANOVA	3.01e-05
s.dist	0.622
p.adjustANOVA	0.000307

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AKR1C2	11983
NCOA1	11850
NCOA2	11316
AKR1D1	11002
AKR1C3	10899
AKR1C4	10624
CYP7A1	10415
PTGIS	9444
AKR1C1	9386
NR1H4	8904
HSD3B7	7229
CYP7B1	5213
RXRA	1201
CYP8B1	-2427
CYP27A1	-7770

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AKR1C2	11983
NCOA1	11850
NCOA2	11316
AKR1D1	11002
AKR1C3	10899
AKR1C4	10624
CYP7A1	10415
PTGIS	9444
AKR1C1	9386
NR1H4	8904
HSD3B7	7229
CYP7B1	5213
RXRA	1201
CYP8B1	-2427
CYP27A1	-7770

---

Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes

	227
set	Condensation of Prometaphase Chromosomes
setSize	11
pANOVA	0.000834
s.dist	-0.582
p.adjustANOVA	0.00559

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SMC2	-13274
CSNK2B	-12911
NCAPG	-12205
CDK1	-11312
NCAPD2	-10309
CCNB2	-10158
SMC4	-9685
CSNK2A1	-5044
NCAPH	-4957
CCNB1	-4375
CSNK2A2	1372

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SMC2	-13274
CSNK2B	-12911
NCAPG	-12205
CDK1	-11312
NCAPD2	-10309
CCNB2	-10158
SMC4	-9685
CSNK2A1	-5044
NCAPH	-4957
CCNB1	-4375
CSNK2A2	1372

---

Peptide chain elongation

Peptide chain elongation

	896
set	Peptide chain elongation
setSize	84
pANOVA	1.02e-18
s.dist	-0.557
p.adjustANOVA	9.15e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
RPL19	-13092
RPL27	-12969
EEF1A1	-12952
RPL9	-12907
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563
RPL6	-12485

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
RPL19	-13092.0
RPL27	-12969.0
EEF1A1	-12952.0
RPL9	-12907.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
RPL18	-11666.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
RPS12	-10547.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
RPLP0	-8553.0
RPS11	-8400.0
RPL10L	-7761.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
EEF2	-6608.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
RPLP2	-4894.0
RPL13	-4560.0
RPL7	-4298.0
RPL13A	-3686.5
RPS5	-2364.0
RPS7	-2102.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
RPS15	4094.0
RPS24	4144.0
RPS3	5704.0

---

Viral mRNA Translation

Viral mRNA Translation

	1478
set	Viral mRNA Translation
setSize	84
pANOVA	7.05e-18
s.dist	-0.543
p.adjustANOVA	4.68e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
RPL19	-13092
RPL27	-12969
RPL9	-12907
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563
RPL6	-12485
RPL29	-12324

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
RPL19	-13092.0
RPL27	-12969.0
RPL9	-12907.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
RPL18	-11666.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
RPS12	-10547.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
RPLP0	-8553.0
RPS11	-8400.0
GRSF1	-8032.0
RPL10L	-7761.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
RPLP2	-4894.0
RPL13	-4560.0
RPL7	-4298.0
RPL13A	-3686.5
RPS5	-2364.0
RPS7	-2102.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
DNAJC3	3563.0
RPS15	4094.0
RPS24	4144.0
RPS3	5704.0

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	395
set	Eukaryotic Translation Elongation
setSize	88
pANOVA	1.43e-18
s.dist	-0.542
p.adjustANOVA	1.15e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
EEF1B2	-13614
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
RPL19	-13092
RPL27	-12969
EEF1A1	-12952
RPL9	-12907
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
EEF1B2	-13614.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
RPL19	-13092.0
RPL27	-12969.0
EEF1A1	-12952.0
RPL9	-12907.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
RPL18	-11666.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
RPS12	-10547.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
RPLP0	-8553.0
RPS11	-8400.0
RPL10L	-7761.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
EEF2	-6608.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
RPLP2	-4894.0
RPL13	-4560.0
RPL7	-4298.0
RPL13A	-3686.5
EEF1A2	-3573.0
EEF1D	-3401.0
RPS5	-2364.0
RPS7	-2102.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
RPS15	4094.0
RPS24	4144.0
EEF1G	5639.0
RPS3	5704.0

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	397
set	Eukaryotic Translation Termination
setSize	87
pANOVA	8.18e-18
s.dist	-0.533
p.adjustANOVA	4.81e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
RPL19	-13092
RPL27	-12969
RPL9	-12907
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563
RPL6	-12485
RPL29	-12324

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
RPL19	-13092.0
RPL27	-12969.0
RPL9	-12907.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
RPL18	-11666.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
RPS12	-10547.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
RPL10A	-9123.0
GSPT1	-9116.0
RPS15A	-9067.0
RPS2	-9049.0
RPLP0	-8553.0
RPS11	-8400.0
RPL10L	-7761.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
TRMT112	-5219.0
RPLP2	-4894.0
RPL13	-4560.0
RPL7	-4298.0
RPL13A	-3686.5
N6AMT1	-2660.0
RPS5	-2364.0
RPS7	-2102.0
RPL3	-1360.0
RPS20	-1186.0
APEH	-1151.0
RPS29	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
ETF1	1866.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
RPS15	4094.0
RPS24	4144.0
RPS3	5704.0

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

	1135
set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	95
pANOVA	7.47e-19
s.dist	-0.526
p.adjustANOVA	7.13e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
EIF2S2	-13188
RPL19	-13092
RPL27	-12969
RPL9	-12907
ATF4	-12845
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
EIF2S2	-13188.0
RPL19	-13092.0
RPL27	-12969.0
RPL9	-12907.0
ATF4	-12845.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
DDIT3	-12359.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
CEBPB	-12055.0
RPS13	-12002.0
RPS21	-11920.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
RPL18	-11666.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
RPS12	-10547.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
ASNS	-9763.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
RPLP0	-8553.0
RPS11	-8400.0
ATF2	-8378.0
CEBPG	-8201.0
RPL10L	-7761.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
RPS27	-6357.0
ATF3	-6250.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
EIF2S1	-5537.0
RPLP2	-4894.0
RPL13	-4560.0
TRIB3	-4350.0
RPL7	-4298.0
RPL13A	-3686.5
RPS5	-2364.0
RPS7	-2102.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
GCN1	4010.0
RPS15	4094.0
RPS24	4144.0
RPS3	5704.0
IMPACT	7394.0
EIF2AK4	11633.0

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	1172
set	SRP-dependent cotranslational protein targeting to membrane
setSize	105
pANOVA	1.44e-20
s.dist	-0.524
p.adjustANOVA	1.57e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
SRP54	-13242
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
RPL19	-13092
RPL27	-12969
RPL9	-12907
SEC11A	-12894
SRP72	-12795
RPS16	-12785
RPL35A	-12711
RPL24	-12638

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
SRP54	-13242.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
RPL19	-13092.0
RPL27	-12969.0
RPL9	-12907.0
SEC11A	-12894.0
SRP72	-12795.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
SRP14	-12510.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
SEC11C	-12295.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
SEC61A1	-12040.0
RPS13	-12002.0
RPS21	-11920.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
RPL18	-11666.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPN1	-11151.0
SEC61G	-11071.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
RPS12	-10547.0
RPL27A	-10491.0
SSR3	-10292.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
SRP19	-8913.0
RPLP0	-8553.0
RPS11	-8400.0
SEC61B	-8013.0
SPCS1	-7887.0
SPCS3	-7773.0
RPL10L	-7761.0
RPL28	-7701.0
RPN2	-7273.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
SSR2	-5067.0
RPLP2	-4894.0
RPL13	-4560.0
RPL7	-4298.0
RPL13A	-3686.5
SEC61A2	-3316.0
RPS5	-2364.0
SPCS2	-2284.0
RPS7	-2102.0
RPL3	-1360.0
RPS20	-1186.0
SRPRB	-1163.0
RPS29	0.5
TRAM1	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
SRP68	3304.0
DDOST	3600.0
SRP9	4013.0
RPS15	4094.0
RPS24	4144.0
SSR1	4408.0
RPS3	5704.0

---

Selenocysteine synthesis

Selenocysteine synthesis

	1193
set	Selenocysteine synthesis
setSize	87
pANOVA	4.08e-17
s.dist	-0.521
p.adjustANOVA	2.31e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
RPL19	-13092
RPL27	-12969
RPL9	-12907
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563
RPL6	-12485
RPL29	-12324

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
RPL19	-13092.0
RPL27	-12969.0
RPL9	-12907.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
RPL18	-11666.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
RPS12	-10547.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
RPL10A	-9123.0
RPS15A	-9067.0
SEPHS2	-9064.0
RPS2	-9049.0
RPLP0	-8553.0
RPS11	-8400.0
RPL10L	-7761.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
SEPSECS	-5208.0
RPLP2	-4894.0
RPL13	-4560.0
RPL7	-4298.0
RPL13A	-3686.5
RPS5	-2364.0
RPS7	-2102.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
EEFSEC	2764.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
RPS15	4094.0
SECISBP2	4107.0
RPS24	4144.0
PSTK	4201.0
RPS3	5704.0

---

APC/C:Cdc20 mediated degradation of Cyclin B

APC/C:Cdc20 mediated degradation of Cyclin B

	13
set	APC/C:Cdc20 mediated degradation of Cyclin B
setSize	24
pANOVA	1.38e-05
s.dist	-0.512
p.adjustANOVA	0.000154

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
ANAPC1	-13688
ANAPC7	-13531
CDC26	-13498
ANAPC15	-12924
UBC	-12755
ANAPC10	-12579
CDC23	-12005
UBA52	-11857
CDK1	-11312
CDC20	-10741
UBB	-10007
ANAPC2	-8429
UBE2S	-8227
ANAPC11	-7009
ANAPC4	-6305
CCNB1	-4375
UBE2E1	-3281
ANAPC16	-2518
UBE2D1	-1939

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
ANAPC1	-13688.0
ANAPC7	-13531.0
CDC26	-13498.0
ANAPC15	-12924.0
UBC	-12755.0
ANAPC10	-12579.0
CDC23	-12005.0
UBA52	-11857.0
CDK1	-11312.0
CDC20	-10741.0
UBB	-10007.0
ANAPC2	-8429.0
UBE2S	-8227.0
ANAPC11	-7009.0
ANAPC4	-6305.0
CCNB1	-4375.0
UBE2E1	-3281.0
ANAPC16	-2518.0
UBE2D1	-1939.0
UBE2C	0.5
CDC27	2062.0
ANAPC5	3759.0
CDC16	4267.0

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	449
set	Formation of a pool of free 40S subunits
setSize	95
pANOVA	5.9e-18
s.dist	-0.512
p.adjustANOVA	4.1e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
RPL19	-13092
EIF3F	-13004
RPL27	-12969
RPL9	-12907
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563
RPL6	-12485

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
RPL19	-13092.0
EIF3F	-13004.0
RPL27	-12969.0
RPL9	-12907.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
EIF3I	-11872.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
RPL18	-11666.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
RPS12	-10547.0
EIF3J	-10506.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
EIF3K	-9025.0
RPLP0	-8553.0
RPS11	-8400.0
EIF3E	-8370.0
RPL10L	-7761.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
EIF3B	-5755.0
EIF3C	-5388.0
RPLP2	-4894.0
EIF3M	-4627.0
RPL13	-4560.0
RPL7	-4298.0
RPL13A	-3686.5
RPS5	-2364.0
RPS7	-2102.0
EIF3L	-1817.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
EIF3G	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
EIF3A	3391.0
RPS15	4094.0
RPS24	4144.0
RPS3	5704.0
EIF3D	6595.0
EIF3H	7573.0

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	822
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	89
pANOVA	1.02e-16
s.dist	-0.508
p.adjustANOVA	5.59e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
RPL19	-13092
RPL27	-12969
RPL9	-12907
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563
RPL6	-12485
RPL29	-12324

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
RPL19	-13092.0
RPL27	-12969.0
RPL9	-12907.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
RPL18	-11666.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
RPS12	-10547.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
RPL10A	-9123.0
GSPT1	-9116.0
RPS15A	-9067.0
RPS2	-9049.0
RPLP0	-8553.0
RPS11	-8400.0
RPL10L	-7761.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
NCBP1	-4923.0
RPLP2	-4894.0
RPL13	-4560.0
RPL7	-4298.0
NCBP2	-3768.0
RPL13A	-3686.5
RPS5	-2364.0
RPS7	-2102.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
ETF1	1866.0
PABPC1	1938.0
UPF1	2581.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
RPS15	4094.0
RPS24	4144.0
RPS3	5704.0
EIF4G1	7514.0

---

Class C/3 (Metabotropic glutamate/pheromone receptors)

Class C/3 (Metabotropic glutamate/pheromone receptors)

	212
set	Class C/3 (Metabotropic glutamate/pheromone receptors)
setSize	39
pANOVA	5.14e-08
s.dist	0.504
p.adjustANOVA	1.08e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAS2R3	11830
TAS2R5	11791
TAS2R7	11653
GPRC6A	11588
TAS2R8	11447
TAS2R50	11302
GRM1	11142
TAS2R46	10762
TAS2R30	10645
TAS2R1	10455
TAS2R31	10427
TAS2R19	9814
TAS2R39	9544
TAS2R38	9539
TAS2R10	9262
TAS2R41	9114
TAS2R60	8984
TAS2R42	8935
GRM7	8536
TAS2R9	6888

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAS2R3	11830.0
TAS2R5	11791.0
TAS2R7	11653.0
GPRC6A	11588.0
TAS2R8	11447.0
TAS2R50	11302.0
GRM1	11142.0
TAS2R46	10762.0
TAS2R30	10645.0
TAS2R1	10455.0
TAS2R31	10427.0
TAS2R19	9814.0
TAS2R39	9544.0
TAS2R38	9539.0
TAS2R10	9262.0
TAS2R41	9114.0
TAS2R60	8984.0
TAS2R42	8935.0
GRM7	8536.0
TAS2R9	6888.0
GRM5	6353.0
TAS2R16	5504.0
GABBR1	5301.0
TAS2R14	4705.0
CASR	4672.0
GRM3	4259.0
TAS1R2	3467.0
GABBR2	3182.0
TAS1R3	1706.0
GRM8	1669.0
TAS2R13	0.5
TAS2R4	0.5
TAS2R43	0.5
GRM6	-1428.0
TAS1R1	-2098.0
TAS2R40	-3497.0
TAS2R20	-3857.0
GRM2	-4076.0
GRM4	-5936.0

---

Hormone ligand-binding receptors

Hormone ligand-binding receptors

	567
set	Hormone ligand-binding receptors
setSize	13
pANOVA	0.00186
s.dist	0.498
p.adjustANOVA	0.0112

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TSHB	12043
GPHB5	11906
CGA	11373
LHCGR	10034
GNRH1	9849
GNRHR	9088
FSHR	8219
FSHB	6039
GNRH2	4715
LHB	2568
GPHA2	2402
TSHR	-1813
GNRHR2	-12741

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TSHB	12043
GPHB5	11906
CGA	11373
LHCGR	10034
GNRH1	9849
GNRHR	9088
FSHR	8219
FSHB	6039
GNRH2	4715
LHB	2568
GPHA2	2402
TSHR	-1813
GNRHR2	-12741

---

RIPK1-mediated regulated necrosis

RIPK1-mediated regulated necrosis

	1014
set	RIPK1-mediated regulated necrosis
setSize	27
pANOVA	7.52e-06
s.dist	-0.498
p.adjustANOVA	9.34e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TNFRSF10B	-13907
RPS27A	-13891
CASP8	-13465
CFLAR	-12925
UBC	-12755
FAS	-12652
TRADD	-12508
UBA52	-11857
FLOT1	-11571
RIPK3	-11373
HSP90AA1	-10935
PDCD6IP	-10193
UBB	-10007
TRAF2	-8877
STUB1	-8729
BIRC2	-7232
FLOT2	-6678
CDC37	-6532
BIRC3	-5212
FADD	-5065

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TNFRSF10B	-13907.0
RPS27A	-13891.0
CASP8	-13465.0
CFLAR	-12925.0
UBC	-12755.0
FAS	-12652.0
TRADD	-12508.0
UBA52	-11857.0
FLOT1	-11571.0
RIPK3	-11373.0
HSP90AA1	-10935.0
PDCD6IP	-10193.0
UBB	-10007.0
TRAF2	-8877.0
STUB1	-8729.0
BIRC2	-7232.0
FLOT2	-6678.0
CDC37	-6532.0
BIRC3	-5212.0
FADD	-5065.0
TNFSF10	-3900.0
PELI1	-3314.0
TNFRSF10A	-1806.0
FASLG	0.5
SDCBP	3005.0
MLKL	4131.0
RIPK1	10040.0

---

Regulation of necroptotic cell death

Regulation of necroptotic cell death

	1116
set	Regulation of necroptotic cell death
setSize	27
pANOVA	7.52e-06
s.dist	-0.498
p.adjustANOVA	9.34e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TNFRSF10B	-13907
RPS27A	-13891
CASP8	-13465
CFLAR	-12925
UBC	-12755
FAS	-12652
TRADD	-12508
UBA52	-11857
FLOT1	-11571
RIPK3	-11373
HSP90AA1	-10935
PDCD6IP	-10193
UBB	-10007
TRAF2	-8877
STUB1	-8729
BIRC2	-7232
FLOT2	-6678
CDC37	-6532
BIRC3	-5212
FADD	-5065

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TNFRSF10B	-13907.0
RPS27A	-13891.0
CASP8	-13465.0
CFLAR	-12925.0
UBC	-12755.0
FAS	-12652.0
TRADD	-12508.0
UBA52	-11857.0
FLOT1	-11571.0
RIPK3	-11373.0
HSP90AA1	-10935.0
PDCD6IP	-10193.0
UBB	-10007.0
TRAF2	-8877.0
STUB1	-8729.0
BIRC2	-7232.0
FLOT2	-6678.0
CDC37	-6532.0
BIRC3	-5212.0
FADD	-5065.0
TNFSF10	-3900.0
PELI1	-3314.0
TNFRSF10A	-1806.0
FASLG	0.5
SDCBP	3005.0
MLKL	4131.0
RIPK1	10040.0

---

Pexophagy

Pexophagy

	903
set	Pexophagy
setSize	11
pANOVA	0.00425
s.dist	-0.498
p.adjustANOVA	0.0219

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
ATM	-13315
UBC	-12755
NBR1	-11910
UBA52	-11857
PEX5	-10505
SQSTM1	-10419
UBB	-10007
MAP1LC3B	-1227
USP30	6621
EPAS1	8472

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891
ATM	-13315
UBC	-12755
NBR1	-11910
UBA52	-11857
PEX5	-10505
SQSTM1	-10419
UBB	-10007
MAP1LC3B	-1227
USP30	6621
EPAS1	8472

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	493
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	105
pANOVA	1.75e-18
s.dist	-0.495
p.adjustANOVA	1.33e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
EIF2S2	-13188
RPL19	-13092
EIF3F	-13004
RPL27	-12969
RPL9	-12907
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
EIF2S2	-13188.0
RPL19	-13092.0
EIF3F	-13004.0
RPL27	-12969.0
RPL9	-12907.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
EIF3I	-11872.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
RPL18	-11666.0
EIF4A1	-11533.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
EIF4A2	-10715.0
RPS12	-10547.0
EIF3J	-10506.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
EIF3K	-9025.0
RPLP0	-8553.0
RPS11	-8400.0
EIF3E	-8370.0
RPL10L	-7761.0
EIF4B	-7722.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
EIF4H	-5758.0
EIF3B	-5755.0
EIF2S1	-5537.0
EIF3C	-5388.0
EIF5	-5033.0
RPLP2	-4894.0
EIF3M	-4627.0
RPL13	-4560.0
RPL7	-4298.0
RPL13A	-3686.5
RPS5	-2364.0
RPS7	-2102.0
EIF3L	-1817.0
EIF5B	-1551.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
EIF3G	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
EIF4E	2096.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
EIF3A	3391.0
RPS15	4094.0
RPS24	4144.0
RPS3	5704.0
EIF3D	6595.0
EIF4G1	7514.0
EIF3H	7573.0

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	660
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	104
pANOVA	2.93e-18
s.dist	-0.494
p.adjustANOVA	2.13e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
EIF2S2	-13188
RPL19	-13092
EIF3F	-13004
RPL27	-12969
RPL9	-12907
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
EIF2S2	-13188.0
RPL19	-13092.0
EIF3F	-13004.0
RPL27	-12969.0
RPL9	-12907.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
EIF3I	-11872.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
RPL18	-11666.0
EIF4A1	-11533.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
EIF4A2	-10715.0
RPS12	-10547.0
EIF3J	-10506.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
EIF3K	-9025.0
RPLP0	-8553.0
RPS11	-8400.0
EIF3E	-8370.0
RPL10L	-7761.0
EIF4B	-7722.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
EIF4H	-5758.0
EIF3B	-5755.0
EIF2S1	-5537.0
EIF3C	-5388.0
RPLP2	-4894.0
EIF3M	-4627.0
RPL13	-4560.0
RPL7	-4298.0
RPL13A	-3686.5
RPS5	-2364.0
RPS7	-2102.0
EIF3L	-1817.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
EIF3G	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
PABPC1	1938.0
EIF4E	2096.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
EIF3A	3391.0
RPS15	4094.0
RPS24	4144.0
RPS3	5704.0
EIF3D	6595.0
EIF4G1	7514.0
EIF3H	7573.0

---

Activation of the phototransduction cascade

Activation of the phototransduction cascade

	56
set	Activation of the phototransduction cascade
setSize	11
pANOVA	0.00463
s.dist	0.493
p.adjustANOVA	0.0234

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CNGA1	12145
SLC24A1	9884
SAG	9585
GNGT1	8403
PDE6G	6939
PDE6A	6066
GNB1	5362
RHO	5093
CNGB1	4024
GNAT1	-2742
PDE6B	-3166

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CNGA1	12145
SLC24A1	9884
SAG	9585
GNGT1	8403
PDE6G	6939
PDE6A	6066
GNB1	5362
RHO	5093
CNGB1	4024
GNAT1	-2742
PDE6B	-3166

---

RUNX3 regulates p14-ARF

RUNX3 regulates p14-ARF

	1052
set	RUNX3 regulates p14-ARF
setSize	10
pANOVA	0.00751
s.dist	-0.488
p.adjustANOVA	0.0345

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BRD2	-13638
CDKN2A	-13509
CCND1	-12520
TGFB1	-12422
KRAS	-12378
RUNX1	-7474
RUNX3	-6442
CBFB	-1895
HDAC4	3041
EP300	5043

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BRD2	-13638
CDKN2A	-13509
CCND1	-12520
TGFB1	-12422
KRAS	-12378
RUNX1	-7474
RUNX3	-6442
CBFB	-1895
HDAC4	3041
EP300	5043

---

Activation of the TFAP2 (AP-2) family of transcription factors

Activation of the TFAP2 (AP-2) family of transcription factors

	54
set	Activation of the TFAP2 (AP-2) family of transcription factors
setSize	11
pANOVA	0.00514
s.dist	-0.487
p.adjustANOVA	0.025

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TFAP2D	-13859
TFAP2B	-13693
CITED2	-13588
TFAP2A	-13088
YEATS4	-12772
TFAP2E	-12058
CITED4	-8296
TFAP2C	-6055
CREBBP	-1588
EP300	5043
WWOX	10677

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TFAP2D	-13859
TFAP2B	-13693
CITED2	-13588
TFAP2A	-13088
YEATS4	-12772
TFAP2E	-12058
CITED4	-8296
TFAP2C	-6055
CREBBP	-1588
EP300	5043
WWOX	10677

---

APC-Cdc20 mediated degradation of Nek2A

APC-Cdc20 mediated degradation of Nek2A

	11
set	APC-Cdc20 mediated degradation of Nek2A
setSize	26
pANOVA	2.41e-05
s.dist	-0.478
p.adjustANOVA	0.000256

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
ANAPC1	-13688
ANAPC7	-13531
CDC26	-13498
ANAPC15	-12924
UBC	-12755
ANAPC10	-12579
CDC23	-12005
UBA52	-11857
NEK2	-11013
CDC20	-10741
UBB	-10007
ANAPC2	-8429
UBE2S	-8227
ANAPC11	-7009
ANAPC4	-6305
UBE2E1	-3281
MAD2L1	-3202
BUB3	-2952
ANAPC16	-2518

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
ANAPC1	-13688.0
ANAPC7	-13531.0
CDC26	-13498.0
ANAPC15	-12924.0
UBC	-12755.0
ANAPC10	-12579.0
CDC23	-12005.0
UBA52	-11857.0
NEK2	-11013.0
CDC20	-10741.0
UBB	-10007.0
ANAPC2	-8429.0
UBE2S	-8227.0
ANAPC11	-7009.0
ANAPC4	-6305.0
UBE2E1	-3281.0
MAD2L1	-3202.0
BUB3	-2952.0
ANAPC16	-2518.0
BUB1B	-1997.0
UBE2D1	-1939.0
UBE2C	0.5
CDC27	2062.0
ANAPC5	3759.0
CDC16	4267.0

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

	165
set	Cap-dependent Translation Initiation
setSize	112
pANOVA	7.81e-18
s.dist	-0.47
p.adjustANOVA	4.78e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
EIF2S2	-13188
RPL19	-13092
EIF3F	-13004
RPL27	-12969
RPL9	-12907
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
EIF2S2	-13188.0
RPL19	-13092.0
EIF3F	-13004.0
RPL27	-12969.0
RPL9	-12907.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
EIF3I	-11872.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
EIF2B5	-11689.0
RPL18	-11666.0
EIF4A1	-11533.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
EIF4A2	-10715.0
RPS12	-10547.0
EIF3J	-10506.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
EIF2B2	-9683.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
EIF3K	-9025.0
RPLP0	-8553.0
RPS11	-8400.0
EIF3E	-8370.0
RPL10L	-7761.0
EIF4B	-7722.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
EIF2B4	-5790.0
EIF4H	-5758.0
EIF3B	-5755.0
EIF2S1	-5537.0
EIF3C	-5388.0
EIF5	-5033.0
RPLP2	-4894.0
EIF3M	-4627.0
RPL13	-4560.0
RPL7	-4298.0
RPL13A	-3686.5
RPS5	-2364.0
EIF2B1	-2133.0
RPS7	-2102.0
EIF3L	-1817.0
EIF5B	-1551.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
EIF3G	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
PABPC1	1938.0
EIF4E	2096.0
EIF4EBP1	2340.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
EIF3A	3391.0
RPS15	4094.0
RPS24	4144.0
RPS3	5704.0
EIF3D	6595.0
EIF4G1	7514.0
EIF3H	7573.0
EIF2B3	10570.0

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

	396
set	Eukaryotic Translation Initiation
setSize	112
pANOVA	7.81e-18
s.dist	-0.47
p.adjustANOVA	4.78e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
RPS14	-13759
RPL14	-13587
RPL34	-13475
RPL41	-13386
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
EIF2S2	-13188
RPL19	-13092
EIF3F	-13004
RPL27	-12969
RPL9	-12907
RPS16	-12785
RPL35A	-12711
RPL24	-12638
RPS25	-12563

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
RPS14	-13759.0
RPL14	-13587.0
RPL34	-13475.0
RPL41	-13386.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
EIF2S2	-13188.0
RPL19	-13092.0
EIF3F	-13004.0
RPL27	-12969.0
RPL9	-12907.0
RPS16	-12785.0
RPL35A	-12711.0
RPL24	-12638.0
RPS25	-12563.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
EIF3I	-11872.0
UBA52	-11857.0
RPS10	-11819.0
RPL32	-11750.0
EIF2B5	-11689.0
RPL18	-11666.0
EIF4A1	-11533.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RPSA	-11050.0
RPL7A	-10984.0
RPL36	-10914.0
RPL4	-10718.0
EIF4A2	-10715.0
RPS12	-10547.0
EIF3J	-10506.0
RPL27A	-10491.0
RPL38	-10056.0
RPL30	-9969.0
RPS26	-9949.0
RPL22	-9807.0
EIF2B2	-9683.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
EIF3K	-9025.0
RPLP0	-8553.0
RPS11	-8400.0
EIF3E	-8370.0
RPL10L	-7761.0
EIF4B	-7722.0
RPL28	-7701.0
RPL21	-6802.5
RPL35	-6756.0
RPS6	-6677.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RPL8	-6047.0
EIF2B4	-5790.0
EIF4H	-5758.0
EIF3B	-5755.0
EIF2S1	-5537.0
EIF3C	-5388.0
EIF5	-5033.0
RPLP2	-4894.0
EIF3M	-4627.0
RPL13	-4560.0
RPL7	-4298.0
RPL13A	-3686.5
RPS5	-2364.0
EIF2B1	-2133.0
RPS7	-2102.0
EIF3L	-1817.0
EIF5B	-1551.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
EIF3G	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
RPL22L1	1649.0
RPL5	1756.0
PABPC1	1938.0
EIF4E	2096.0
EIF4EBP1	2340.0
RPL17	2794.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
EIF3A	3391.0
RPS15	4094.0
RPS24	4144.0
RPS3	5704.0
EIF3D	6595.0
EIF4G1	7514.0
EIF3H	7573.0
EIF2B3	10570.0

---

Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol

	699
set	Major pathway of rRNA processing in the nucleolus and cytosol
setSize	171
pANOVA	1.4e-25
s.dist	-0.462
p.adjustANOVA	2.14e-23

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
UTP3	-13776
RPS14	-13759
UTP15	-13595
RPL14	-13587
RPL34	-13475
RPP21	-13403
RPL41	-13386
UTP6	-13329
EXOSC5	-13282
EMG1	-13281
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
RPL19	-13092
IMP4	-13032
IMP3	-13028

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
UTP3	-13776.0
RPS14	-13759.0
UTP15	-13595.0
RPL14	-13587.0
RPL34	-13475.0
RPP21	-13403.0
RPL41	-13386.0
UTP6	-13329.0
EXOSC5	-13282.0
EMG1	-13281.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
RPL19	-13092.0
IMP4	-13032.0
IMP3	-13028.0
EXOSC9	-13025.0
RPL27	-12969.0
RPL9	-12907.0
XRN2	-12798.0
RPS16	-12785.0
NOL11	-12731.0
RPL35A	-12711.0
EXOSC8	-12704.0
MPHOSPH10	-12681.0
RPL24	-12638.0
RPS25	-12563.0
WDR75	-12553.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
ISG20L2	-12296.0
RPP30	-12253.0
RRP7A	-12250.0
WDR18	-12196.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
WDR3	-11871.0
UBA52	-11857.0
RPS10	-11819.0
EXOSC4	-11772.0
RPL32	-11750.0
DDX52	-11695.0
RPL18	-11666.0
WDR36	-11615.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RIOK2	-11438.0
WDR46	-11286.0
FTSJ3	-11263.0
EBNA1BP2	-11083.0
RPSA	-11050.0
BYSL	-11037.0
RPL7A	-10984.0
RPL36	-10914.0
NOL6	-10838.0
DCAF13	-10766.0
PNO1	-10745.0
SNU13	-10728.0
RPL4	-10718.0
RPS12	-10547.0
RPL27A	-10491.0
DIS3	-10457.0
PES1	-10257.0
PDCD11	-10201.0
RPL38	-10056.0
EXOSC1	-10021.0
RPL30	-9969.0
TBL3	-9951.0
RPS26	-9949.0
RIOK3	-9834.0
RPL22	-9807.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
DDX21	-9033.0
MPHOSPH6	-8679.0
RPLP0	-8553.0
PELP1	-8438.0
RPS11	-8400.0
LTV1	-7929.0
PWP2	-7845.0
RPP25	-7789.0
RPL10L	-7761.0
RPL28	-7701.0
RPP40	-7667.0
EXOSC3	-7602.0
NOL12	-7195.0
C1D	-6848.0
RPL21	-6802.5
RPL35	-6756.0
BOP1	-6754.0
RPS6	-6677.0
CSNK1E	-6572.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RBM28	-6072.0
RPL8	-6047.0
UTP20	-6042.0
NOL9	-5629.0
EXOSC10	-5198.0
GNL3	-5001.0
RPLP2	-4894.0
HEATR1	-4683.0
RRP1	-4634.0
RPL13	-4560.0
EXOSC2	-4559.0
RPL7	-4298.0
NOP56	-4032.0
EXOSC6	-4006.0
DDX49	-3823.0
RPL13A	-3686.5
RIOK1	-3466.0
UTP18	-3135.0
FCF1	-3024.0
RPS5	-2364.0
WBSCR22	-2152.0
RPS7	-2102.0
NOB1	-1871.0
ERI1	-1505.0
RPL3	-1360.0
RPS20	-1186.0
RPS29	0.5
RRP36	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
SENP3	1445.0
RPL22L1	1649.0
RPL5	1756.0
KRR1	1824.0
NIP7	1828.0
CSNK1D	1949.0
RPP38	2040.0
EXOSC7	2117.0
FBL	2342.0
BMS1	2421.0
RPP14	2793.0
RPL17	2794.0
DHX37	2813.0
DDX47	2944.0
WDR12	2950.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
NOP14	3691.0
NOC4L	3818.0
RPS15	4094.0
RPS24	4144.0
NCL	5308.0
RPS3	5704.0
RRP9	5839.0
TSR1	5944.0
RCL1	6109.0
WDR43	6313.0
NOP58	7237.0
TEX10	7664.0
UTP14C	10373.0

---

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

	1334
set	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
setSize	24
pANOVA	9.38e-05
s.dist	0.46
p.adjustANOVA	0.000853

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AKR1C2	11983
NCOA1	11850
NCOA2	11316
AKR1D1	11002
AKR1C3	10899
AKR1C4	10624
BAAT	10481
CYP7A1	10415
PTGIS	9444
AKR1C1	9386
NR1H4	8904
ACOX2	8477
ABCB11	8258
SLC27A2	7278
HSD3B7	7229
CYP7B1	5213
HSD17B4	3984
SCP2	1733
RXRA	1201
CYP8B1	-2427

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AKR1C2	11983
NCOA1	11850
NCOA2	11316
AKR1D1	11002
AKR1C3	10899
AKR1C4	10624
BAAT	10481
CYP7A1	10415
PTGIS	9444
AKR1C1	9386
NR1H4	8904
ACOX2	8477
ABCB11	8258
SLC27A2	7278
HSD3B7	7229
CYP7B1	5213
HSD17B4	3984
SCP2	1733
RXRA	1201
CYP8B1	-2427
SLC27A5	-5913
AMACR	-7023
CYP27A1	-7770
ACOT8	-12416

---

rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol

	1522
set	rRNA processing in the nucleus and cytosol
setSize	180
pANOVA	1.89e-26
s.dist	-0.459
p.adjustANOVA	3.2e-24

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
UTP3	-13776
RPS14	-13759
UTP15	-13595
RPL14	-13587
RPL34	-13475
RPP21	-13403
RPL41	-13386
UTP6	-13329
EXOSC5	-13282
EMG1	-13281
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
RPL19	-13092
IMP4	-13032
IMP3	-13028

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
UTP3	-13776.0
RPS14	-13759.0
UTP15	-13595.0
RPL14	-13587.0
RPL34	-13475.0
RPP21	-13403.0
RPL41	-13386.0
UTP6	-13329.0
EXOSC5	-13282.0
EMG1	-13281.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
RPL19	-13092.0
IMP4	-13032.0
IMP3	-13028.0
EXOSC9	-13025.0
RPL27	-12969.0
RPL9	-12907.0
THUMPD1	-12873.0
XRN2	-12798.0
RPS16	-12785.0
NOL11	-12731.0
RPL35A	-12711.0
EXOSC8	-12704.0
MPHOSPH10	-12681.0
RPL24	-12638.0
RPS25	-12563.0
WDR75	-12553.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
ISG20L2	-12296.0
RPP30	-12253.0
RRP7A	-12250.0
WDR18	-12196.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
WDR3	-11871.0
UBA52	-11857.0
RPS10	-11819.0
EXOSC4	-11772.0
RPL32	-11750.0
DDX52	-11695.0
RPL18	-11666.0
WDR36	-11615.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RIOK2	-11438.0
WDR46	-11286.0
FTSJ3	-11263.0
EBNA1BP2	-11083.0
RPSA	-11050.0
BYSL	-11037.0
RPL7A	-10984.0
RPL36	-10914.0
NOL6	-10838.0
GAR1	-10797.0
DCAF13	-10766.0
PNO1	-10745.0
SNU13	-10728.0
RPL4	-10718.0
RPS12	-10547.0
RPL27A	-10491.0
DIS3	-10457.0
PES1	-10257.0
PDCD11	-10201.0
RPL38	-10056.0
EXOSC1	-10021.0
RPL30	-9969.0
TBL3	-9951.0
RPS26	-9949.0
RIOK3	-9834.0
RPL22	-9807.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
DDX21	-9033.0
NOP10	-8979.0
MPHOSPH6	-8679.0
RPLP0	-8553.0
PELP1	-8438.0
RPS11	-8400.0
LTV1	-7929.0
PWP2	-7845.0
RPP25	-7789.0
RPL10L	-7761.0
RPL28	-7701.0
RPP40	-7667.0
EXOSC3	-7602.0
NOL12	-7195.0
C1D	-6848.0
RPL21	-6802.5
RPL35	-6756.0
BOP1	-6754.0
RPS6	-6677.0
CSNK1E	-6572.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RBM28	-6072.0
RPL8	-6047.0
UTP20	-6042.0
NOL9	-5629.0
TSR3	-5586.0
TRMT112	-5219.0
EXOSC10	-5198.0
GNL3	-5001.0
RPLP2	-4894.0
HEATR1	-4683.0
RRP1	-4634.0
RPL13	-4560.0
EXOSC2	-4559.0
DIMT1	-4448.0
RPL7	-4298.0
NOP56	-4032.0
EXOSC6	-4006.0
DDX49	-3823.0
RPL13A	-3686.5
RIOK1	-3466.0
UTP18	-3135.0
FCF1	-3024.0
NAT10	-2504.0
RPS5	-2364.0
WBSCR22	-2152.0
RPS7	-2102.0
NOB1	-1871.0
ERI1	-1505.0
NHP2	-1388.0
RPL3	-1360.0
NOP2	-1211.0
RPS20	-1186.0
RPS29	0.5
RRP36	0.5
RPS17	0.5
RPL36AL	1129.0
RPS9	1443.0
SENP3	1445.0
RPL22L1	1649.0
RPL5	1756.0
KRR1	1824.0
NIP7	1828.0
CSNK1D	1949.0
RPP38	2040.0
EXOSC7	2117.0
FBL	2342.0
BMS1	2421.0
RPP14	2793.0
RPL17	2794.0
DHX37	2813.0
DDX47	2944.0
WDR12	2950.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
NOP14	3691.0
NOC4L	3818.0
RPS15	4094.0
RPS24	4144.0
NCL	5308.0
RPS3	5704.0
RRP9	5839.0
TSR1	5944.0
RCL1	6109.0
WDR43	6313.0
NOP58	7237.0
TEX10	7664.0
UTP14C	10373.0

---

Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization

	530
set	Golgi Cisternae Pericentriolar Stack Reorganization
setSize	14
pANOVA	0.00294
s.dist	-0.459
p.adjustANOVA	0.0162

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RAB1B	-13720
MAPK3	-12849
USO1	-12157
CDK1	-11312
BLZF1	-10508
CCNB2	-10158
RAB1A	-9801
GOLGA2	-8260
PLK1	-8217
CCNB1	-4375
RAB2A	-4003
GORASP2	-2400
GORASP1	4885
MAPK1	7161

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RAB1B	-13720
MAPK3	-12849
USO1	-12157
CDK1	-11312
BLZF1	-10508
CCNB2	-10158
RAB1A	-9801
GOLGA2	-8260
PLK1	-8217
CCNB1	-4375
RAB2A	-4003
GORASP2	-2400
GORASP1	4885
MAPK1	7161

---

CASP8 activity is inhibited

CASP8 activity is inhibited

	135
set	CASP8 activity is inhibited
setSize	11
pANOVA	0.00854
s.dist	-0.458
p.adjustANOVA	0.0381

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TNFRSF10B	-13907.0
CASP8	-13465.0
CFLAR	-12925.0
FAS	-12652.0
TRADD	-12508.0
TRAF2	-8877.0
FADD	-5065.0
TNFSF10	-3900.0
TNFRSF10A	-1806.0
FASLG	0.5
RIPK1	10040.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TNFRSF10B	-13907.0
CASP8	-13465.0
CFLAR	-12925.0
FAS	-12652.0
TRADD	-12508.0
TRAF2	-8877.0
FADD	-5065.0
TNFSF10	-3900.0
TNFRSF10A	-1806.0
FASLG	0.5
RIPK1	10040.0

---

Dimerization of procaspase-8

Dimerization of procaspase-8

	319
set	Dimerization of procaspase-8
setSize	11
pANOVA	0.00854
s.dist	-0.458
p.adjustANOVA	0.0381

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TNFRSF10B	-13907.0
CASP8	-13465.0
CFLAR	-12925.0
FAS	-12652.0
TRADD	-12508.0
TRAF2	-8877.0
FADD	-5065.0
TNFSF10	-3900.0
TNFRSF10A	-1806.0
FASLG	0.5
RIPK1	10040.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TNFRSF10B	-13907.0
CASP8	-13465.0
CFLAR	-12925.0
FAS	-12652.0
TRADD	-12508.0
TRAF2	-8877.0
FADD	-5065.0
TNFSF10	-3900.0
TNFRSF10A	-1806.0
FASLG	0.5
RIPK1	10040.0

---

Regulation by c-FLIP

Regulation by c-FLIP

	1070
set	Regulation by c-FLIP
setSize	11
pANOVA	0.00854
s.dist	-0.458
p.adjustANOVA	0.0381

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TNFRSF10B	-13907.0
CASP8	-13465.0
CFLAR	-12925.0
FAS	-12652.0
TRADD	-12508.0
TRAF2	-8877.0
FADD	-5065.0
TNFSF10	-3900.0
TNFRSF10A	-1806.0
FASLG	0.5
RIPK1	10040.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TNFRSF10B	-13907.0
CASP8	-13465.0
CFLAR	-12925.0
FAS	-12652.0
TRADD	-12508.0
TRAF2	-8877.0
FADD	-5065.0
TNFSF10	-3900.0
TNFRSF10A	-1806.0
FASLG	0.5
RIPK1	10040.0

---

SUMOylation of immune response proteins

SUMOylation of immune response proteins

	1183
set	SUMOylation of immune response proteins
setSize	10
pANOVA	0.0127
s.dist	-0.455
p.adjustANOVA	0.0517

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PIAS3	-13438
TOPORS	-12275
NFKB2	-10060
IKBKE	-9034
RELA	-8456
PIAS4	-8451
NFKBIA	-8138
SUMO1	-7591
UBE2I	2470
SUMO3	7132

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PIAS3	-13438
TOPORS	-12275
NFKB2	-10060
IKBKE	-9034
RELA	-8456
PIAS4	-8451
NFKBIA	-8138
SUMO1	-7591
UBE2I	2470
SUMO3	7132

---

TICAM1-dependent activation of IRF3/IRF7

TICAM1-dependent activation of IRF3/IRF7

	1350
set	TICAM1-dependent activation of IRF3/IRF7
setSize	12
pANOVA	0.00639
s.dist	-0.454
p.adjustANOVA	0.0304

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
IRF7	-13163
UBC	-12755
TLR3	-12507
TICAM1	-12298
UBA52	-11857
UBB	-10007
IKBKE	-9034
TANK	-1935
IRF3	2550
TBK1	3783
TRAF3	9750

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891
IRF7	-13163
UBC	-12755
TLR3	-12507
TICAM1	-12298
UBA52	-11857
UBB	-10007
IKBKE	-9034
TANK	-1935
IRF3	2550
TBK1	3783
TRAF3	9750

---

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase

	237
set	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
setSize	20
pANOVA	0.000433
s.dist	-0.454
p.adjustANOVA	0.00324

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ANAPC1	-13688.0
ANAPC7	-13531.0
CDC26	-13498.0
ANAPC15	-12924.0
ANAPC10	-12579.0
CDC23	-12005.0
FZR1	-11517.0
CDC20	-10741.0
ANAPC2	-8429.0
UBE2S	-8227.0
CDC14A	-7431.0
ANAPC11	-7009.0
ANAPC4	-6305.0
UBE2E1	-3281.0
ANAPC16	-2518.0
UBE2D1	-1939.0
UBE2C	0.5
CDC27	2062.0
ANAPC5	3759.0
CDC16	4267.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ANAPC1	-13688.0
ANAPC7	-13531.0
CDC26	-13498.0
ANAPC15	-12924.0
ANAPC10	-12579.0
CDC23	-12005.0
FZR1	-11517.0
CDC20	-10741.0
ANAPC2	-8429.0
UBE2S	-8227.0
CDC14A	-7431.0
ANAPC11	-7009.0
ANAPC4	-6305.0
UBE2E1	-3281.0
ANAPC16	-2518.0
UBE2D1	-1939.0
UBE2C	0.5
CDC27	2062.0
ANAPC5	3759.0
CDC16	4267.0

---

Mitochondrial translation termination

Mitochondrial translation termination

	746
set	Mitochondrial translation termination
setSize	87
pANOVA	4.25e-13
s.dist	-0.449
p.adjustANOVA	1.67e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL51	-13801
MRPS18B	-13665
MRPL46	-13599
MRPS33	-13547
MRPS11	-13513
MRPL41	-13381
MTRF1L	-13362
MRPS5	-13145
MRPL57	-13072
MRPL37	-13054
MRPS16	-12997
MRPL50	-12819
MRPL30	-12721
MRPS18C	-12717
MRPL2	-12434
DAP3	-12399
MRPL54	-12351
MRPL11	-12133
GADD45GIP1	-11394
MRPL15	-11096

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL51	-13801.0
MRPS18B	-13665.0
MRPL46	-13599.0
MRPS33	-13547.0
MRPS11	-13513.0
MRPL41	-13381.0
MTRF1L	-13362.0
MRPS5	-13145.0
MRPL57	-13072.0
MRPL37	-13054.0
MRPS16	-12997.0
MRPL50	-12819.0
MRPL30	-12721.0
MRPS18C	-12717.0
MRPL2	-12434.0
DAP3	-12399.0
MRPL54	-12351.0
MRPL11	-12133.0
GADD45GIP1	-11394.0
MRPL15	-11096.0
MRPL39	-10886.0
MRPL47	-10743.0
MRPS30	-10474.0
MRPL43	-10432.0
MRPS2	-10333.0
MRPS10	-10325.0
MRPL49	-10289.0
OXA1L	-10164.0
MRPS23	-10129.0
MRPS18A	-9840.0
MRPS31	-9805.0
MRPL4	-9727.0
MRPS15	-9607.0
PTCD3	-9306.0
ERAL1	-9265.0
MRPS24	-9263.0
CHCHD1	-9189.0
MRPL36	-9071.0
MRPS7	-8922.0
MRPL1	-8661.0
MRPL32	-8431.0
MRPL9	-8356.0
MRPL3	-8331.0
GFM2	-8218.0
MRPS35	-8190.0
MRPL17	-7787.0
MRPS21	-7783.0
MRPL40	-7517.0
MRPS26	-7366.0
MRPL14	-7268.0
MRPL53	-7199.0
MRPS12	-6957.0
MRPS9	-6903.0
AURKAIP1	-6898.0
MRPS22	-6390.0
MRPL18	-6115.0
MRPS6	-5670.0
MRPL33	-5657.0
MRPL52	-5606.0
MRPS36	-5398.0
MRPL10	-5254.0
MRPS17	-4956.0
MRPL27	-4189.0
MRPL34	-3561.0
MRPL16	-3498.0
MRPL35	-3430.0
MRPL44	-3303.0
MRPL13	-2432.0
MRPL24	-1953.0
MRPL28	-1882.0
MRPL12	-1786.0
MRPS28	-1759.0
MRRF	-1637.0
MRPL55	-1228.0
MRPS34	0.5
MRPL21	1184.0
MRPL23	1648.0
MRPL20	1700.0
MRPL42	1737.0
MRPS14	2164.0
MRPL38	3597.0
MRPL45	4639.0
MRPL19	5634.0
MRPS25	5846.0
MRPS27	6286.0
MRPL22	8290.0
MRPL48	11583.0

---

Mitochondrial translation elongation

Mitochondrial translation elongation

	744
set	Mitochondrial translation elongation
setSize	87
pANOVA	6.54e-13
s.dist	-0.445
p.adjustANOVA	2.5e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL51	-13801
MRPS18B	-13665
MRPL46	-13599
MRPS33	-13547
MRPS11	-13513
MRPL41	-13381
MRPS5	-13145
MRPL57	-13072
MRPL37	-13054
MRPS16	-12997
MRPL50	-12819
MRPL30	-12721
MRPS18C	-12717
MRPL2	-12434
DAP3	-12399
MRPL54	-12351
MRPL11	-12133
TUFM	-11798
GADD45GIP1	-11394
MRPL15	-11096

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL51	-13801.0
MRPS18B	-13665.0
MRPL46	-13599.0
MRPS33	-13547.0
MRPS11	-13513.0
MRPL41	-13381.0
MRPS5	-13145.0
MRPL57	-13072.0
MRPL37	-13054.0
MRPS16	-12997.0
MRPL50	-12819.0
MRPL30	-12721.0
MRPS18C	-12717.0
MRPL2	-12434.0
DAP3	-12399.0
MRPL54	-12351.0
MRPL11	-12133.0
TUFM	-11798.0
GADD45GIP1	-11394.0
MRPL15	-11096.0
MRPL39	-10886.0
MRPL47	-10743.0
MRPS30	-10474.0
MRPL43	-10432.0
MRPS2	-10333.0
MRPS10	-10325.0
MRPL49	-10289.0
OXA1L	-10164.0
MRPS23	-10129.0
MRPS18A	-9840.0
MRPS31	-9805.0
MRPL4	-9727.0
MRPS15	-9607.0
PTCD3	-9306.0
ERAL1	-9265.0
MRPS24	-9263.0
CHCHD1	-9189.0
MRPL36	-9071.0
MRPS7	-8922.0
MRPL1	-8661.0
MRPL32	-8431.0
MRPL9	-8356.0
MRPL3	-8331.0
MRPS35	-8190.0
MRPL17	-7787.0
MRPS21	-7783.0
MRPL40	-7517.0
MRPS26	-7366.0
MRPL14	-7268.0
MRPL53	-7199.0
MRPS12	-6957.0
MRPS9	-6903.0
AURKAIP1	-6898.0
MRPS22	-6390.0
MRPL18	-6115.0
MRPS6	-5670.0
MRPL33	-5657.0
MRPL52	-5606.0
MRPS36	-5398.0
MRPL10	-5254.0
MRPS17	-4956.0
TSFM	-4944.0
MRPL27	-4189.0
MRPL34	-3561.0
MRPL16	-3498.0
MRPL35	-3430.0
MRPL44	-3303.0
MRPL13	-2432.0
GFM1	-2360.0
MRPL24	-1953.0
MRPL28	-1882.0
MRPL12	-1786.0
MRPS28	-1759.0
MRPL55	-1228.0
MRPS34	0.5
MRPL21	1184.0
MRPL23	1648.0
MRPL20	1700.0
MRPL42	1737.0
MRPS14	2164.0
MRPL38	3597.0
MRPL45	4639.0
MRPL19	5634.0
MRPS25	5846.0
MRPS27	6286.0
MRPL22	8290.0
MRPL48	11583.0

---

Erythropoietin activates RAS

Erythropoietin activates RAS

	391
set	Erythropoietin activates RAS
setSize	14
pANOVA	0.004
s.dist	-0.444
p.adjustANOVA	0.0208

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EPO	-13566
HRAS	-13113
NRAS	-12748
KRAS	-12378
IRS2	-12285
CRKL	-12121
VAV1	-10413
SHC1	-9916
RAPGEF1	-4842
JAK2	-2030
SOS1	-1197
GRB2	1727
EPOR	1735
LYN	8124

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EPO	-13566
HRAS	-13113
NRAS	-12748
KRAS	-12378
IRS2	-12285
CRKL	-12121
VAV1	-10413
SHC1	-9916
RAPGEF1	-4842
JAK2	-2030
SOS1	-1197
GRB2	1727
EPOR	1735
LYN	8124

---

Interleukin-2 signaling

Interleukin-2 signaling

	628
set	Interleukin-2 signaling
setSize	11
pANOVA	0.0108
s.dist	-0.444
p.adjustANOVA	0.0461

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAT5A	-13850.0
LCK	-13301.0
STAT5B	-10454.0
PTK2B	-10222.0
IL2RB	-9917.0
SHC1	-9916.0
JAK3	-9246.0
SYK	-6321.0
IL2	0.5
JAK1	3909.0
IL2RA	6260.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAT5A	-13850.0
LCK	-13301.0
STAT5B	-10454.0
PTK2B	-10222.0
IL2RB	-9917.0
SHC1	-9916.0
JAK3	-9246.0
SYK	-6321.0
IL2	0.5
JAK1	3909.0
IL2RA	6260.0

---

SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery

	1154
set	SARS-CoV-2 modulates host translation machinery
setSize	46
pANOVA	1.88e-07
s.dist	-0.444
p.adjustANOVA	3.34e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
GEMIN4	-13809
RPS14	-13759
SNRPG	-13268
RPS23	-13229
RPS18	-13212
RPS16	-12785
DDX20	-12778
RPS25	-12563
RPS27L	-12178
RPS8	-12116
FAU	-12115
RPS13	-12002
RPS21	-11920
RPS10	-11819
SNRPF	-11787
RPS19	-11509
RPSA	-11050
SNRPD2	-10651
RPS12	-10547

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
GEMIN4	-13809.0
RPS14	-13759.0
SNRPG	-13268.0
RPS23	-13229.0
RPS18	-13212.0
RPS16	-12785.0
DDX20	-12778.0
RPS25	-12563.0
RPS27L	-12178.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
RPS10	-11819.0
SNRPF	-11787.0
RPS19	-11509.0
RPSA	-11050.0
SNRPD2	-10651.0
RPS12	-10547.0
RPS26	-9949.0
SNRPD1	-9689.0
RPS15A	-9067.0
RPS2	-9049.0
RPS11	-8400.0
GEMIN6	-7715.0
SNRPE	-7069.0
RPS6	-6677.0
RPS27	-6357.0
SNRPB	-3071.0
RPS5	-2364.0
RPS7	-2102.0
GEMIN7	-1822.0
RPS20	-1186.0
RPS29	0.5
SMN1	0.5
GEMIN5	0.5
RPS17	0.5
RPS9	1443.0
SNRPD3	1874.0
GEMIN2	2638.0
RPS3A	3222.0
RPS28	3288.0
RPS15	4094.0
RPS24	4144.0
RPS3	5704.0

---

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

	239
set	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
setSize	32
pANOVA	1.57e-05
s.dist	-0.441
p.adjustANOVA	0.000173

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PFDN6	-13814
PFDN5	-13618
TUBA3E	-13326
TUBA4A	-13094
TUBB4B	-12933
TUBA4B	-12095
CCT3	-12020
TUBA3C	-11752
TUBB3	-11598
TUBB2B	-10859
PFDN1	-10698
TUBA1B	-10354
ACTB	-10156
TUBA8	-9541
CCT6B	-9166
CCT5	-9136
PFDN4	-8233
CCT7	-7163
TUBB4A	-7085
CCT8	-6934

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PFDN6	-13814
PFDN5	-13618
TUBA3E	-13326
TUBA4A	-13094
TUBB4B	-12933
TUBA4B	-12095
CCT3	-12020
TUBA3C	-11752
TUBB3	-11598
TUBB2B	-10859
PFDN1	-10698
TUBA1B	-10354
ACTB	-10156
TUBA8	-9541
CCT6B	-9166
CCT5	-9136
PFDN4	-8233
CCT7	-7163
TUBB4A	-7085
CCT8	-6934
PFDN2	-6381
CCT4	-5330
TUBA1C	-4543
CCT6A	-4357
TCP1	-2346
TUBB2A	-2260
TUBA1A	1393
TUBA3D	2263
TUBB6	2724
TUBB1	3209
TUBAL3	8565
CCT2	9473

---

SCF(Skp2)-mediated degradation of p27/p21

SCF(Skp2)-mediated degradation of p27/p21

	1157
set	SCF(Skp2)-mediated degradation of p27/p21
setSize	58
pANOVA	7.47e-09
s.dist	-0.438
p.adjustANOVA	1.87e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
CDKN1B	-13860
PSMD7	-13652
PSMA5	-13278
PSMD12	-13034
UBC	-12755
CCNE2	-12720
CKS1B	-12684
PSMD13	-12572
PSMD4	-12522
CCND1	-12520
CUL1	-12480
PSMB5	-12257
PSMC6	-12249
PSMC5	-12147
PSMB6	-11942
PSMC4	-11877
UBA52	-11857
PSMA7	-11458
PSMB3	-11395

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891
CDKN1B	-13860
PSMD7	-13652
PSMA5	-13278
PSMD12	-13034
UBC	-12755
CCNE2	-12720
CKS1B	-12684
PSMD13	-12572
PSMD4	-12522
CCND1	-12520
CUL1	-12480
PSMB5	-12257
PSMC6	-12249
PSMC5	-12147
PSMB6	-11942
PSMC4	-11877
UBA52	-11857
PSMA7	-11458
PSMB3	-11395
PSMB8	-10956
PSMB1	-10802
PSMD2	-10694
PSMC2	-10641
PSMA1	-10184
PSMB10	-10076
PSME3	-10027
PSMA2	-10011
UBB	-10007
PSMA3	-9681
CDK4	-9325
PSME2	-9238
PSMB9	-8069
PSMA4	-7957
PSMA6	-7452
PSMD3	-7338
CCNA2	-6997
SKP2	-6660
CDKN1A	-5048
SKP1	-4924
PSMC1	-4823
PSMC3	-4098
PSMB7	-3496
PSMB2	-2978
CCNA1	-2632
PSMF1	-1628
PTK6	-1477
PSME1	1145
PSMB4	1598
PSMD8	3088
CDK2	3409
CCNE1	3632
PSMD9	5698
PSMD6	7556
PSMD1	9283
PSMD14	9726
PSMD11	10746
PSMD5	11962

---

Mitochondrial translation

Mitochondrial translation

	743
set	Mitochondrial translation
setSize	93
pANOVA	2.66e-13
s.dist	-0.438
p.adjustANOVA	1.07e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL51	-13801
MRPS18B	-13665
MRPL46	-13599
MRPS33	-13547
MRPS11	-13513
MRPL41	-13381
MTRF1L	-13362
MRPS5	-13145
MRPL57	-13072
MRPL37	-13054
MRPS16	-12997
MRPL50	-12819
MRPL30	-12721
MRPS18C	-12717
MRPL2	-12434
DAP3	-12399
MRPL54	-12351
MRPL11	-12133
MTIF3	-11981
TUFM	-11798

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL51	-13801.0
MRPS18B	-13665.0
MRPL46	-13599.0
MRPS33	-13547.0
MRPS11	-13513.0
MRPL41	-13381.0
MTRF1L	-13362.0
MRPS5	-13145.0
MRPL57	-13072.0
MRPL37	-13054.0
MRPS16	-12997.0
MRPL50	-12819.0
MRPL30	-12721.0
MRPS18C	-12717.0
MRPL2	-12434.0
DAP3	-12399.0
MRPL54	-12351.0
MRPL11	-12133.0
MTIF3	-11981.0
TUFM	-11798.0
GADD45GIP1	-11394.0
MRPL15	-11096.0
MRPL39	-10886.0
MRPL47	-10743.0
MRPS30	-10474.0
MRPL43	-10432.0
MRPS2	-10333.0
MRPS10	-10325.0
MRPL49	-10289.0
OXA1L	-10164.0
MRPS23	-10129.0
MRPS18A	-9840.0
MRPS31	-9805.0
MRPL4	-9727.0
MRPS15	-9607.0
PTCD3	-9306.0
ERAL1	-9265.0
MRPS24	-9263.0
CHCHD1	-9189.0
MRPL36	-9071.0
MRPS7	-8922.0
MRPL1	-8661.0
MRPL32	-8431.0
MRPL9	-8356.0
MRPL3	-8331.0
GFM2	-8218.0
MRPS35	-8190.0
MRPL17	-7787.0
MRPS21	-7783.0
MRPL40	-7517.0
MRPS26	-7366.0
MRPL14	-7268.0
MRPL53	-7199.0
MRPS12	-6957.0
MRPS9	-6903.0
AURKAIP1	-6898.0
MRPS22	-6390.0
MRPL18	-6115.0
MRPS6	-5670.0
MRPL33	-5657.0
MRPL52	-5606.0
MRPS36	-5398.0
MRPL10	-5254.0
MRPS17	-4956.0
TSFM	-4944.0
MRPL27	-4189.0
MRPL34	-3561.0
MRPL16	-3498.0
MRPL35	-3430.0
MRPL44	-3303.0
MRPL13	-2432.0
GFM1	-2360.0
MRPL24	-1953.0
MRPL28	-1882.0
MRPL12	-1786.0
MRPS28	-1759.0
MRRF	-1637.0
MRPL55	-1228.0
MRPS34	0.5
MRPL21	1184.0
MTIF2	1283.0
MRPL23	1648.0
MRPL20	1700.0
MRPL42	1737.0
MRPS14	2164.0
MTFMT	2954.0
MRPL38	3597.0
MRPL45	4639.0
MRPL19	5634.0
MRPS25	5846.0
MRPS27	6286.0
MRPL22	8290.0
MRPL48	11583.0

---

Mitochondrial translation initiation

Mitochondrial translation initiation

	745
set	Mitochondrial translation initiation
setSize	87
pANOVA	2.11e-12
s.dist	-0.435
p.adjustANOVA	7.88e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL51	-13801
MRPS18B	-13665
MRPL46	-13599
MRPS33	-13547
MRPS11	-13513
MRPL41	-13381
MRPS5	-13145
MRPL57	-13072
MRPL37	-13054
MRPS16	-12997
MRPL50	-12819
MRPL30	-12721
MRPS18C	-12717
MRPL2	-12434
DAP3	-12399
MRPL54	-12351
MRPL11	-12133
MTIF3	-11981
GADD45GIP1	-11394
MRPL15	-11096

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL51	-13801.0
MRPS18B	-13665.0
MRPL46	-13599.0
MRPS33	-13547.0
MRPS11	-13513.0
MRPL41	-13381.0
MRPS5	-13145.0
MRPL57	-13072.0
MRPL37	-13054.0
MRPS16	-12997.0
MRPL50	-12819.0
MRPL30	-12721.0
MRPS18C	-12717.0
MRPL2	-12434.0
DAP3	-12399.0
MRPL54	-12351.0
MRPL11	-12133.0
MTIF3	-11981.0
GADD45GIP1	-11394.0
MRPL15	-11096.0
MRPL39	-10886.0
MRPL47	-10743.0
MRPS30	-10474.0
MRPL43	-10432.0
MRPS2	-10333.0
MRPS10	-10325.0
MRPL49	-10289.0
OXA1L	-10164.0
MRPS23	-10129.0
MRPS18A	-9840.0
MRPS31	-9805.0
MRPL4	-9727.0
MRPS15	-9607.0
PTCD3	-9306.0
ERAL1	-9265.0
MRPS24	-9263.0
CHCHD1	-9189.0
MRPL36	-9071.0
MRPS7	-8922.0
MRPL1	-8661.0
MRPL32	-8431.0
MRPL9	-8356.0
MRPL3	-8331.0
MRPS35	-8190.0
MRPL17	-7787.0
MRPS21	-7783.0
MRPL40	-7517.0
MRPS26	-7366.0
MRPL14	-7268.0
MRPL53	-7199.0
MRPS12	-6957.0
MRPS9	-6903.0
AURKAIP1	-6898.0
MRPS22	-6390.0
MRPL18	-6115.0
MRPS6	-5670.0
MRPL33	-5657.0
MRPL52	-5606.0
MRPS36	-5398.0
MRPL10	-5254.0
MRPS17	-4956.0
MRPL27	-4189.0
MRPL34	-3561.0
MRPL16	-3498.0
MRPL35	-3430.0
MRPL44	-3303.0
MRPL13	-2432.0
MRPL24	-1953.0
MRPL28	-1882.0
MRPL12	-1786.0
MRPS28	-1759.0
MRPL55	-1228.0
MRPS34	0.5
MRPL21	1184.0
MTIF2	1283.0
MRPL23	1648.0
MRPL20	1700.0
MRPL42	1737.0
MRPS14	2164.0
MTFMT	2954.0
MRPL38	3597.0
MRPL45	4639.0
MRPL19	5634.0
MRPS25	5846.0
MRPS27	6286.0
MRPL22	8290.0
MRPL48	11583.0

---

Autodegradation of Cdh1 by Cdh1:APC/C

Autodegradation of Cdh1 by Cdh1:APC/C

	106
set	Autodegradation of Cdh1 by Cdh1:APC/C
setSize	62
pANOVA	3.16e-09
s.dist	-0.435
p.adjustANOVA	8.61e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
ANAPC1	-13688
PSMD7	-13652
ANAPC7	-13531
CDC26	-13498
PSMA5	-13278
PSMD12	-13034
ANAPC15	-12924
UBC	-12755
ANAPC10	-12579
PSMD13	-12572
PSMD4	-12522
PSMB5	-12257
PSMC6	-12249
PSMC5	-12147
CDC23	-12005
PSMB6	-11942
PSMC4	-11877
UBA52	-11857
FZR1	-11517

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
ANAPC1	-13688.0
PSMD7	-13652.0
ANAPC7	-13531.0
CDC26	-13498.0
PSMA5	-13278.0
PSMD12	-13034.0
ANAPC15	-12924.0
UBC	-12755.0
ANAPC10	-12579.0
PSMD13	-12572.0
PSMD4	-12522.0
PSMB5	-12257.0
PSMC6	-12249.0
PSMC5	-12147.0
CDC23	-12005.0
PSMB6	-11942.0
PSMC4	-11877.0
UBA52	-11857.0
FZR1	-11517.0
PSMA7	-11458.0
PSMB3	-11395.0
PSMB8	-10956.0
PSMB1	-10802.0
PSMD2	-10694.0
PSMC2	-10641.0
PSMA1	-10184.0
PSMB10	-10076.0
PSME3	-10027.0
PSMA2	-10011.0
UBB	-10007.0
PSMA3	-9681.0
PSME2	-9238.0
ANAPC2	-8429.0
UBE2S	-8227.0
PSMB9	-8069.0
PSMA4	-7957.0
PSMA6	-7452.0
PSMD3	-7338.0
ANAPC11	-7009.0
ANAPC4	-6305.0
PSMC1	-4823.0
PSMC3	-4098.0
PSMB7	-3496.0
UBE2E1	-3281.0
PSMB2	-2978.0
ANAPC16	-2518.0
UBE2D1	-1939.0
PSMF1	-1628.0
UBE2C	0.5
PSME1	1145.0
PSMB4	1598.0
CDC27	2062.0
PSMD8	3088.0
ANAPC5	3759.0
CDC16	4267.0
PSMD9	5698.0
PSMD6	7556.0
PSMD1	9283.0
PSMD14	9726.0
PSMD11	10746.0
PSMD5	11962.0

---

Reactions specific to the complex N-glycan synthesis pathway

Reactions specific to the complex N-glycan synthesis pathway

	1056
set	Reactions specific to the complex N-glycan synthesis pathway
setSize	10
pANOVA	0.0175
s.dist	0.434
p.adjustANOVA	0.0649

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FUT8	11409
CGA	11373
FUCA1	9951
MAN2A1	6578
CHST10	5964
FUT3	5635
CHST8	2681
LHB	2568
MGAT2	1195
MAN2A2	-9063

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FUT8	11409
CGA	11373
FUCA1	9951
MAN2A1	6578
CHST10	5964
FUT3	5635
CHST8	2681
LHB	2568
MGAT2	1195
MAN2A2	-9063

---

KSRP (KHSRP) binds and destabilizes mRNA

KSRP (KHSRP) binds and destabilizes mRNA

	652
set	KSRP (KHSRP) binds and destabilizes mRNA
setSize	17
pANOVA	0.00195
s.dist	-0.434
p.adjustANOVA	0.0115

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EXOSC5	-13282
EXOSC9	-13025
EXOSC8	-12704
EXOSC4	-11772
YWHAZ	-11607
DIS3	-10457
EXOSC1	-10021
MAPK11	-8205
EXOSC3	-7602
DCP2	-7057
AKT1	-6990
EXOSC2	-4559
EXOSC6	-4006
MAPK14	-3525
KHSRP	1481
EXOSC7	2117
PARN	10567

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EXOSC5	-13282
EXOSC9	-13025
EXOSC8	-12704
EXOSC4	-11772
YWHAZ	-11607
DIS3	-10457
EXOSC1	-10021
MAPK11	-8205
EXOSC3	-7602
DCP2	-7057
AKT1	-6990
EXOSC2	-4559
EXOSC6	-4006
MAPK14	-3525
KHSRP	1481
EXOSC7	2117
PARN	10567

---

rRNA processing

rRNA processing

	1521
set	rRNA processing
setSize	186
pANOVA	2.11e-24
s.dist	-0.433
p.adjustANOVA	2.92e-22

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-13891
RPL23	-13786
UTP3	-13776
RPS14	-13759
UTP15	-13595
RPL14	-13587
RPL34	-13475
RPP21	-13403
RPL41	-13386
UTP6	-13329
EXOSC5	-13282
EMG1	-13281
RPL11	-13267
RPS23	-13229
RPL15	-13226
RPS18	-13212
RPL12	-13196
RPL19	-13092
IMP4	-13032
IMP3	-13028

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-13891.0
RPL23	-13786.0
UTP3	-13776.0
RPS14	-13759.0
UTP15	-13595.0
RPL14	-13587.0
RPL34	-13475.0
RPP21	-13403.0
RPL41	-13386.0
UTP6	-13329.0
EXOSC5	-13282.0
EMG1	-13281.0
RPL11	-13267.0
RPS23	-13229.0
RPL15	-13226.0
RPS18	-13212.0
RPL12	-13196.0
RPL19	-13092.0
IMP4	-13032.0
IMP3	-13028.0
EXOSC9	-13025.0
RPL27	-12969.0
RPL9	-12907.0
THUMPD1	-12873.0
XRN2	-12798.0
RPS16	-12785.0
NOL11	-12731.0
RPL35A	-12711.0
EXOSC8	-12704.0
MPHOSPH10	-12681.0
RPL24	-12638.0
RPS25	-12563.0
WDR75	-12553.0
RPL6	-12485.0
RPL29	-12324.0
RPL31	-12318.0
ISG20L2	-12296.0
RPP30	-12253.0
RRP7A	-12250.0
WDR18	-12196.0
RPL3L	-12195.0
RPS27L	-12178.0
RPL37A	-12176.0
RPL26	-12161.0
RPS8	-12116.0
FAU	-12115.0
RPS13	-12002.0
RPS21	-11920.0
WDR3	-11871.0
UBA52	-11857.0
RPS10	-11819.0
EXOSC4	-11772.0
RPL32	-11750.0
DDX52	-11695.0
RPL18	-11666.0
WDR36	-11615.0
RPS19	-11509.0
RPL23A	-11489.0
RPLP1	-11464.0
RIOK2	-11438.0
WDR46	-11286.0
FTSJ3	-11263.0
EBNA1BP2	-11083.0
RPSA	-11050.0
BYSL	-11037.0
RPL7A	-10984.0
RPL36	-10914.0
NOL6	-10838.0
GAR1	-10797.0
DCAF13	-10766.0
PNO1	-10745.0
SNU13	-10728.0
RPL4	-10718.0
RPS12	-10547.0
RPL27A	-10491.0
DIS3	-10457.0
PES1	-10257.0
PDCD11	-10201.0
RPL38	-10056.0
EXOSC1	-10021.0
RPL30	-9969.0
TBL3	-9951.0
RPS26	-9949.0
RIOK3	-9834.0
RPL22	-9807.0
RPL10A	-9123.0
RPS15A	-9067.0
RPS2	-9049.0
DDX21	-9033.0
NOP10	-8979.0
MPHOSPH6	-8679.0
RPLP0	-8553.0
PELP1	-8438.0
RPS11	-8400.0
MRM1	-8131.0
LTV1	-7929.0
PWP2	-7845.0
RPP25	-7789.0
RPL10L	-7761.0
RPL28	-7701.0
RPP40	-7667.0
EXOSC3	-7602.0
NOL12	-7195.0
C1D	-6848.0
RPL21	-6802.5
RPL35	-6756.0
BOP1	-6754.0
RPS6	-6677.0
CSNK1E	-6572.0
RPS27	-6357.0
RPL26L1	-6182.0
RPL37	-6118.0
RPL18A	-6093.0
RBM28	-6072.0
RPL8	-6047.0
UTP20	-6042.0
NOL9	-5629.0
TSR3	-5586.0
TRMT112	-5219.0
EXOSC10	-5198.0
GNL3	-5001.0
RPLP2	-4894.0
HEATR1	-4683.0
RRP1	-4634.0
RPL13	-4560.0
EXOSC2	-4559.0
DIMT1	-4448.0
RPL7	-4298.0
NOP56	-4032.0
EXOSC6	-4006.0
DDX49	-3823.0
RPL13A	-3686.5
RIOK1	-3466.0
UTP18	-3135.0
FCF1	-3024.0
NAT10	-2504.0
RPS5	-2364.0
WBSCR22	-2152.0
RPS7	-2102.0
NOB1	-1871.0
ERI1	-1505.0
NHP2	-1388.0
RPL3	-1360.0
NOP2	-1211.0
RPS20	-1186.0
RPS29	0.5
RRP36	0.5
TRMT10C	0.5
RPS17	0.5
RPL36AL	1129.0
NSUN4	1228.0
RPS9	1443.0
SENP3	1445.0
RPL22L1	1649.0
RPL5	1756.0
KRR1	1824.0
NIP7	1828.0
CSNK1D	1949.0
RPP38	2040.0
EXOSC7	2117.0
FBL	2342.0
BMS1	2421.0
RPP14	2793.0
RPL17	2794.0
DHX37	2813.0
DDX47	2944.0
WDR12	2950.0
RPL39L	2997.0
RPS3A	3222.0
RPS28	3288.0
NOP14	3691.0
NOC4L	3818.0
RPS15	4094.0
RPS24	4144.0
NCL	5308.0
RPS3	5704.0
RRP9	5839.0
TSR1	5944.0
RCL1	6109.0
WDR43	6313.0
NOP58	7237.0
TEX10	7664.0
ELAC2	8801.0
MTERF4	9328.0
UTP14C	10373.0
TFB1M	11974.0

---

Phosphorylation of the APC/C

Phosphorylation of the APC/C

	916
set	Phosphorylation of the APC/C
setSize	20
pANOVA	0.000815
s.dist	-0.432
p.adjustANOVA	0.00556

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ANAPC1	-13688.0
ANAPC7	-13531.0
CDC26	-13498.0
ANAPC15	-12924.0
ANAPC10	-12579.0
CDC23	-12005.0
CDK1	-11312.0
ANAPC2	-8429.0
UBE2S	-8227.0
PLK1	-8217.0
ANAPC11	-7009.0
ANAPC4	-6305.0
CCNB1	-4375.0
UBE2E1	-3281.0
ANAPC16	-2518.0
UBE2D1	-1939.0
UBE2C	0.5
CDC27	2062.0
ANAPC5	3759.0
CDC16	4267.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ANAPC1	-13688.0
ANAPC7	-13531.0
CDC26	-13498.0
ANAPC15	-12924.0
ANAPC10	-12579.0
CDC23	-12005.0
CDK1	-11312.0
ANAPC2	-8429.0
UBE2S	-8227.0
PLK1	-8217.0
ANAPC11	-7009.0
ANAPC4	-6305.0
CCNB1	-4375.0
UBE2E1	-3281.0
ANAPC16	-2518.0
UBE2D1	-1939.0
UBE2C	0.5
CDC27	2062.0
ANAPC5	3759.0
CDC16	4267.0

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report