Mitch Report

date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             metric
## PCDHGA1  10.370904
## HOXC4   -15.232610
## PCDHGA2   9.661747
## PAX6    -11.445450
## PCDHGA3   7.859158
## ZFP36L2 -18.624474

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2546
num_genes_in_profile	26148
duplicated_genes_present	0
num_profile_genes_in_sets	10252
num_profile_genes_not_in_sets	15896

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1018
num_genesets_included	1528

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Digestion of dietary carbohydrate	10	2.83e-04	0.663	1.13e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	2.39e-04	-0.639	9.72e-04
Folding of actin by CCT/TriC	10	6.46e-04	-0.623	2.35e-03
SUMOylation of immune response proteins	10	6.72e-04	-0.621	2.41e-03
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	7.74e-05	-0.610	3.56e-04
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	1.31e-03	-0.586	4.40e-03
Beta defensins	32	3.73e-08	0.562	3.70e-07
Defensins	40	1.27e-09	0.554	1.80e-08
FOXO-mediated transcription of cell cycle genes	16	1.37e-04	-0.550	5.93e-04
Inhibition of DNA recombination at telomere	20	2.17e-05	-0.548	1.12e-04
RNA Polymerase III Chain Elongation	18	6.85e-05	-0.542	3.19e-04
NGF-stimulated transcription	39	4.66e-09	-0.542	5.99e-08
ERKs are inactivated	13	7.28e-04	-0.541	2.59e-03
FGFR2 alternative splicing	26	3.31e-06	-0.527	2.04e-05
Processing of Intronless Pre-mRNAs	19	8.77e-05	-0.520	3.98e-04
Mitochondrial translation termination	87	1.22e-16	-0.513	4.90e-15
NRIF signals cell death from the nucleus	16	4.03e-04	-0.511	1.55e-03
Mitochondrial translation initiation	87	2.01e-16	-0.509	7.68e-15
Mitochondrial translation	93	2.51e-17	-0.507	1.07e-15
Regulated proteolysis of p75NTR	11	3.66e-03	-0.506	1.08e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	2.54e-03	-0.503	7.92e-03
Crosslinking of collagen fibrils	10	6.35e-03	-0.498	1.73e-02
Eukaryotic Translation Elongation	88	6.20e-16	-0.498	2.26e-14
Interaction With Cumulus Cells And The Zona Pellucida	11	4.31e-03	0.497	1.24e-02
RUNX3 regulates p14-ARF	10	6.66e-03	-0.495	1.79e-02
RNA Polymerase III Transcription Termination	23	4.15e-05	-0.493	2.02e-04
Processing of Capped Intronless Pre-mRNA	28	6.68e-06	-0.491	3.79e-05
SRP-dependent cotranslational protein targeting to membrane	105	3.15e-18	-0.491	1.55e-16
Nuclear Events (kinase and transcription factor activation)	60	4.68e-11	-0.491	8.12e-10
Mitochondrial translation elongation	87	2.51e-15	-0.490	7.67e-14
Condensation of Prometaphase Chromosomes	11	4.96e-03	-0.489	1.39e-02
Viral mRNA Translation	84	9.63e-15	-0.488	2.78e-13
Activation of the AP-1 family of transcription factors	10	7.51e-03	-0.488	1.97e-02
Signaling by FGFR2 IIIa TM	19	2.51e-04	-0.485	1.01e-03
Expression and translocation of olfactory receptors	365	2.25e-57	0.485	1.13e-54
Transcriptional regulation of testis differentiation	12	3.69e-03	-0.484	1.09e-02
RAF-independent MAPK1/3 activation	22	8.74e-05	-0.483	3.98e-04
Translation	263	1.76e-41	-0.482	2.99e-39
SCF(Skp2)-mediated degradation of p27/p21	58	2.26e-10	-0.481	3.67e-09
Peptide chain elongation	84	2.40e-14	-0.481	6.54e-13
Beta-catenin phosphorylation cascade	16	8.93e-04	-0.479	3.12e-03
mRNA Capping	28	1.16e-05	-0.478	6.33e-05
Eukaryotic Translation Termination	87	1.43e-14	-0.477	4.04e-13
Endosomal/Vacuolar pathway	12	4.37e-03	-0.475	1.25e-02
Antimicrobial peptides	82	1.13e-13	0.474	2.65e-12
Cap-dependent Translation Initiation	112	4.50e-18	-0.473	2.09e-16
Eukaryotic Translation Initiation	112	4.50e-18	-0.473	2.09e-16
Glucocorticoid biosynthesis	10	9.57e-03	0.473	2.41e-02
Olfactory Signaling Pathway	372	1.23e-55	0.472	3.75e-53
RNA Pol II CTD phosphorylation and interaction with CE	26	3.03e-05	-0.472	1.52e-04

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Digestion of dietary carbohydrate	10	2.83e-04	6.63e-01	1.13e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	2.39e-04	-6.39e-01	9.72e-04
Folding of actin by CCT/TriC	10	6.46e-04	-6.23e-01	2.35e-03
SUMOylation of immune response proteins	10	6.72e-04	-6.21e-01	2.41e-03
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	7.74e-05	-6.10e-01	3.56e-04
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	1.31e-03	-5.86e-01	4.40e-03
Beta defensins	32	3.73e-08	5.62e-01	3.70e-07
Defensins	40	1.27e-09	5.54e-01	1.80e-08
FOXO-mediated transcription of cell cycle genes	16	1.37e-04	-5.50e-01	5.93e-04
Inhibition of DNA recombination at telomere	20	2.17e-05	-5.48e-01	1.12e-04
RNA Polymerase III Chain Elongation	18	6.85e-05	-5.42e-01	3.19e-04
NGF-stimulated transcription	39	4.66e-09	-5.42e-01	5.99e-08
ERKs are inactivated	13	7.28e-04	-5.41e-01	2.59e-03
FGFR2 alternative splicing	26	3.31e-06	-5.27e-01	2.04e-05
Processing of Intronless Pre-mRNAs	19	8.77e-05	-5.20e-01	3.98e-04
Mitochondrial translation termination	87	1.22e-16	-5.13e-01	4.90e-15
NRIF signals cell death from the nucleus	16	4.03e-04	-5.11e-01	1.55e-03
Mitochondrial translation initiation	87	2.01e-16	-5.09e-01	7.68e-15
Mitochondrial translation	93	2.51e-17	-5.07e-01	1.07e-15
Regulated proteolysis of p75NTR	11	3.66e-03	-5.06e-01	1.08e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	2.54e-03	-5.03e-01	7.92e-03
Crosslinking of collagen fibrils	10	6.35e-03	-4.98e-01	1.73e-02
Eukaryotic Translation Elongation	88	6.20e-16	-4.98e-01	2.26e-14
Interaction With Cumulus Cells And The Zona Pellucida	11	4.31e-03	4.97e-01	1.24e-02
RUNX3 regulates p14-ARF	10	6.66e-03	-4.95e-01	1.79e-02
RNA Polymerase III Transcription Termination	23	4.15e-05	-4.93e-01	2.02e-04
Processing of Capped Intronless Pre-mRNA	28	6.68e-06	-4.91e-01	3.79e-05
SRP-dependent cotranslational protein targeting to membrane	105	3.15e-18	-4.91e-01	1.55e-16
Nuclear Events (kinase and transcription factor activation)	60	4.68e-11	-4.91e-01	8.12e-10
Mitochondrial translation elongation	87	2.51e-15	-4.90e-01	7.67e-14
Condensation of Prometaphase Chromosomes	11	4.96e-03	-4.89e-01	1.39e-02
Viral mRNA Translation	84	9.63e-15	-4.88e-01	2.78e-13
Activation of the AP-1 family of transcription factors	10	7.51e-03	-4.88e-01	1.97e-02
Signaling by FGFR2 IIIa TM	19	2.51e-04	-4.85e-01	1.01e-03
Expression and translocation of olfactory receptors	365	2.25e-57	4.85e-01	1.13e-54
Transcriptional regulation of testis differentiation	12	3.69e-03	-4.84e-01	1.09e-02
RAF-independent MAPK1/3 activation	22	8.74e-05	-4.83e-01	3.98e-04
Translation	263	1.76e-41	-4.82e-01	2.99e-39
SCF(Skp2)-mediated degradation of p27/p21	58	2.26e-10	-4.81e-01	3.67e-09
Peptide chain elongation	84	2.40e-14	-4.81e-01	6.54e-13
Beta-catenin phosphorylation cascade	16	8.93e-04	-4.79e-01	3.12e-03
mRNA Capping	28	1.16e-05	-4.78e-01	6.33e-05
Eukaryotic Translation Termination	87	1.43e-14	-4.77e-01	4.04e-13
Endosomal/Vacuolar pathway	12	4.37e-03	-4.75e-01	1.25e-02
Antimicrobial peptides	82	1.13e-13	4.74e-01	2.65e-12
Cap-dependent Translation Initiation	112	4.50e-18	-4.73e-01	2.09e-16
Eukaryotic Translation Initiation	112	4.50e-18	-4.73e-01	2.09e-16
Glucocorticoid biosynthesis	10	9.57e-03	4.73e-01	2.41e-02
Olfactory Signaling Pathway	372	1.23e-55	4.72e-01	3.75e-53
RNA Pol II CTD phosphorylation and interaction with CE	26	3.03e-05	-4.72e-01	1.52e-04
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	3.03e-05	-4.72e-01	1.52e-04
Early Phase of HIV Life Cycle	14	2.24e-03	-4.72e-01	7.09e-03
Signaling by Activin	15	1.64e-03	-4.69e-01	5.39e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	105	1.53e-16	-4.66e-01	5.98e-15
Formation of a pool of free 40S subunits	95	4.18e-15	-4.65e-01	1.25e-13
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	5.51e-15	-4.63e-01	1.62e-13
Negative regulation of NOTCH4 signaling	52	9.42e-09	-4.60e-01	1.08e-07
Initiation of Nuclear Envelope (NE) Reformation	18	7.30e-04	-4.60e-01	2.59e-03
Selenocysteine synthesis	87	1.56e-13	-4.57e-01	3.57e-12
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	9.37e-14	-4.56e-01	2.31e-12
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	2.52e-08	-4.55e-01	2.58e-07
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	9.05e-03	-4.54e-01	2.29e-02
HIV elongation arrest and recovery	29	2.32e-05	-4.54e-01	1.19e-04
Pausing and recovery of HIV elongation	29	2.32e-05	-4.54e-01	1.19e-04
L13a-mediated translational silencing of Ceruloplasmin expression	104	1.21e-15	-4.54e-01	4.21e-14
Glutamate and glutamine metabolism	12	6.62e-03	-4.53e-01	1.78e-02
SUMOylation of transcription factors	20	5.05e-04	-4.49e-01	1.88e-03
ERK/MAPK targets	20	5.19e-04	-4.48e-01	1.92e-03
Creation of C4 and C2 activators	14	3.77e-03	4.47e-01	1.11e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	6.00e-05	-4.46e-01	2.81e-04
Initial triggering of complement	21	4.03e-04	4.46e-01	1.55e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	108	1.53e-15	-4.44e-01	4.97e-14
Nonsense-Mediated Decay (NMD)	108	1.53e-15	-4.44e-01	4.97e-14
Degradation of cysteine and homocysteine	14	4.07e-03	-4.43e-01	1.19e-02
Pausing and recovery of Tat-mediated HIV elongation	27	6.96e-05	-4.42e-01	3.22e-04
Tat-mediated HIV elongation arrest and recovery	27	6.96e-05	-4.42e-01	3.22e-04
Regulation of expression of SLITs and ROBOs	159	6.79e-22	-4.41e-01	4.71e-20
Activation of the TFAP2 (AP-2) family of transcription factors	11	1.16e-02	-4.39e-01	2.86e-02
FGFRL1 modulation of FGFR1 signaling	13	6.52e-03	-4.36e-01	1.77e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	1.73e-02	-4.35e-01	3.97e-02
Diseases associated with N-glycosylation of proteins	19	1.04e-03	-4.34e-01	3.58e-03
Influenza Viral RNA Transcription and Replication	129	2.89e-17	-4.30e-01	1.19e-15
Digestion	21	6.61e-04	4.29e-01	2.39e-03
Activation of HOX genes during differentiation	61	7.14e-09	-4.28e-01	8.46e-08
Activation of anterior HOX genes in hindbrain development during early embryogenesis	61	7.14e-09	-4.28e-01	8.46e-08
Sulfur amino acid metabolism	27	1.19e-04	-4.28e-01	5.22e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	1.81e-07	-4.26e-01	1.51e-06
p53-Independent DNA Damage Response	50	1.81e-07	-4.26e-01	1.51e-06
p53-Independent G1/S DNA damage checkpoint	50	1.81e-07	-4.26e-01	1.51e-06
Response of EIF2AK1 (HRI) to heme deficiency	14	5.79e-03	-4.26e-01	1.59e-02
Asymmetric localization of PCP proteins	62	6.80e-09	-4.25e-01	8.18e-08
Digestion and absorption	26	1.76e-04	4.25e-01	7.43e-04
Diseases associated with glycosylation precursor biosynthesis	15	4.48e-03	-4.24e-01	1.28e-02
Defective pyroptosis	11	1.49e-02	-4.24e-01	3.52e-02
Abortive elongation of HIV-1 transcript in the absence of Tat	23	4.36e-04	-4.23e-01	1.64e-03
Hh mutants abrogate ligand secretion	57	3.15e-08	-4.23e-01	3.17e-07
Prefoldin mediated transfer of substrate to CCT/TriC	27	1.42e-04	-4.23e-01	6.10e-04
Formation of HIV elongation complex in the absence of HIV Tat	40	3.73e-06	-4.22e-01	2.22e-05
Hh mutants are degraded by ERAD	54	8.01e-08	-4.22e-01	7.42e-07
Ubiquitin-dependent degradation of Cyclin D	50	2.56e-07	-4.21e-01	2.05e-06
RNA Polymerase I Promoter Escape	28	1.16e-04	-4.21e-01	5.10e-04
TP53 Regulates Transcription of DNA Repair Genes	57	4.19e-08	-4.19e-01	4.10e-07
Signaling by NOTCH4	79	1.18e-10	-4.19e-01	2.00e-09
Mitochondrial protein import	54	1.00e-07	-4.19e-01	8.96e-07
Regulation of RUNX3 expression and activity	53	1.33e-07	-4.18e-01	1.15e-06
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	1.34e-07	-4.18e-01	1.15e-06
Vpu mediated degradation of CD4	50	3.31e-07	-4.17e-01	2.57e-06
Cytosolic iron-sulfur cluster assembly	10	2.26e-02	-4.16e-01	4.96e-02
Influenza Infection	148	2.12e-18	-4.16e-01	1.08e-16
SLBP independent Processing of Histone Pre-mRNAs	10	2.29e-02	-4.15e-01	5.00e-02
G1/S DNA Damage Checkpoints	66	5.41e-09	-4.15e-01	6.77e-08
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	7.60e-04	-4.14e-01	2.67e-03
Autodegradation of the E3 ubiquitin ligase COP1	50	4.03e-07	-4.14e-01	3.03e-06
p53-Dependent G1 DNA Damage Response	64	1.06e-08	-4.13e-01	1.19e-07
p53-Dependent G1/S DNA damage checkpoint	64	1.06e-08	-4.13e-01	1.19e-07
Formation of the ternary complex, and subsequently, the 43S complex	47	9.40e-07	-4.13e-01	6.59e-06
Formation of HIV-1 elongation complex containing HIV-1 Tat	38	1.07e-05	-4.12e-01	5.85e-05
HIV Transcription Elongation	38	1.07e-05	-4.12e-01	5.85e-05
Tat-mediated elongation of the HIV-1 transcript	38	1.07e-05	-4.12e-01	5.85e-05
FGFR2 mutant receptor activation	32	5.53e-05	-4.12e-01	2.63e-04
Regulation of ornithine decarboxylase (ODC)	49	6.13e-07	-4.11e-01	4.48e-06
CTNNB1 S33 mutants aren’t phosphorylated	14	7.75e-03	-4.11e-01	2.00e-02
CTNNB1 S37 mutants aren’t phosphorylated	14	7.75e-03	-4.11e-01	2.00e-02
CTNNB1 S45 mutants aren’t phosphorylated	14	7.75e-03	-4.11e-01	2.00e-02
CTNNB1 T41 mutants aren’t phosphorylated	14	7.75e-03	-4.11e-01	2.00e-02
Signaling by CTNNB1 phospho-site mutants	14	7.75e-03	-4.11e-01	2.00e-02
Signaling by GSK3beta mutants	14	7.75e-03	-4.11e-01	2.00e-02
Metabolism of polyamines	55	1.35e-07	-4.11e-01	1.15e-06
Autodegradation of Cdh1 by Cdh1:APC/C	62	2.21e-08	-4.10e-01	2.28e-07
Disorders of Developmental Biology	11	1.85e-02	-4.10e-01	4.21e-02
Disorders of Nervous System Development	11	1.85e-02	-4.10e-01	4.21e-02
Loss of function of MECP2 in Rett syndrome	11	1.85e-02	-4.10e-01	4.21e-02
Pervasive developmental disorders	11	1.85e-02	-4.10e-01	4.21e-02
Degradation of AXIN	53	2.43e-07	-4.10e-01	1.95e-06
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	1.78e-04	-4.09e-01	7.48e-04
Major pathway of rRNA processing in the nucleolus and cytosol	171	2.58e-20	-4.09e-01	1.58e-18
mRNA decay by 5’ to 3’ exoribonuclease	15	6.13e-03	-4.09e-01	1.67e-02
HIV Transcription Initiation	43	3.52e-06	-4.08e-01	2.11e-05
RNA Polymerase II HIV Promoter Escape	43	3.52e-06	-4.08e-01	2.11e-05
RNA Polymerase II Promoter Escape	43	3.52e-06	-4.08e-01	2.11e-05
RNA Polymerase II Transcription Initiation	43	3.52e-06	-4.08e-01	2.11e-05
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	3.52e-06	-4.08e-01	2.11e-05
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	3.52e-06	-4.08e-01	2.11e-05
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	2.53e-02	-4.08e-01	5.41e-02
Pexophagy	11	1.92e-02	-4.08e-01	4.37e-02
Acetylcholine regulates insulin secretion	10	2.58e-02	4.07e-01	5.51e-02
Ribosomal scanning and start codon recognition	54	2.31e-07	-4.07e-01	1.87e-06
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	3.20e-09	-4.06e-01	4.17e-08
Purine ribonucleoside monophosphate biosynthesis	11	1.98e-02	-4.06e-01	4.49e-02
Formation of TC-NER Pre-Incision Complex	51	5.41e-07	-4.05e-01	4.02e-06
Signaling by ALK	26	3.51e-04	-4.05e-01	1.38e-03
SCF-beta-TrCP mediated degradation of Emi1	53	3.41e-07	-4.05e-01	2.63e-06
RUNX2 regulates osteoblast differentiation	22	1.03e-03	-4.04e-01	3.54e-03
APC/C:Cdc20 mediated degradation of mitotic proteins	74	1.80e-09	-4.04e-01	2.50e-08
Selenoamino acid metabolism	103	1.58e-12	-4.03e-01	3.25e-11
Hedgehog ligand biogenesis	63	3.31e-08	-4.02e-01	3.31e-07
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	3.55e-09	-4.02e-01	4.60e-08
Vif-mediated degradation of APOBEC3G	50	8.72e-07	-4.02e-01	6.14e-06
Acetylcholine Neurotransmitter Release Cycle	16	5.44e-03	-4.01e-01	1.51e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	55	2.60e-07	-4.01e-01	2.05e-06
MicroRNA (miRNA) biogenesis	26	4.26e-04	-3.99e-01	1.61e-03
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	4.41e-03	-3.99e-01	1.26e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	4.41e-03	-3.99e-01	1.26e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	1.75e-06	-3.99e-01	1.16e-05
Impaired BRCA2 binding to RAD51	33	7.46e-05	-3.98e-01	3.44e-04
Cyclin E associated events during G1/S transition	81	6.26e-10	-3.97e-01	9.57e-09
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	2.68e-09	-3.97e-01	3.53e-08
Cyclin A:Cdk2-associated events at S phase entry	83	4.14e-10	-3.96e-01	6.46e-09
The role of GTSE1 in G2/M progression after G2 checkpoint	58	1.78e-07	-3.96e-01	1.51e-06
APC truncation mutants have impaired AXIN binding	13	1.34e-02	-3.96e-01	3.21e-02
AXIN missense mutants destabilize the destruction complex	13	1.34e-02	-3.96e-01	3.21e-02
Signaling by AMER1 mutants	13	1.34e-02	-3.96e-01	3.21e-02
Signaling by APC mutants	13	1.34e-02	-3.96e-01	3.21e-02
Signaling by AXIN mutants	13	1.34e-02	-3.96e-01	3.21e-02
Truncations of AMER1 destabilize the destruction complex	13	1.34e-02	-3.96e-01	3.21e-02
XBP1(S) activates chaperone genes	48	2.06e-06	-3.96e-01	1.34e-05
Defective Intrinsic Pathway for Apoptosis	25	6.13e-04	-3.96e-01	2.24e-03
Degradation of beta-catenin by the destruction complex	81	7.27e-10	-3.96e-01	1.09e-08
Negative epigenetic regulation of rRNA expression	45	4.57e-06	-3.95e-01	2.68e-05
Association of TriC/CCT with target proteins during biosynthesis	38	2.67e-05	-3.93e-01	1.35e-04
rRNA processing in the nucleus and cytosol	180	7.86e-20	-3.93e-01	4.62e-18
Translation initiation complex formation	54	6.00e-07	-3.92e-01	4.41e-06
Keratinization	214	4.43e-23	3.92e-01	3.39e-21
Base-Excision Repair, AP Site Formation	18	4.06e-03	-3.91e-01	1.19e-02
Metabolism of cofactors	19	3.19e-03	-3.91e-01	9.62e-03
APC/C:Cdc20 mediated degradation of Securin	66	4.01e-08	-3.90e-01	3.95e-07
Complement cascade	56	4.48e-07	3.90e-01	3.34e-06
CDK-mediated phosphorylation and removal of Cdc6	71	1.35e-08	-3.89e-01	1.46e-07
DNA Damage/Telomere Stress Induced Senescence	28	3.64e-04	-3.89e-01	1.42e-03
Regulation of Apoptosis	51	1.57e-06	-3.88e-01	1.07e-05
MAPK targets/ Nuclear events mediated by MAP kinases	29	2.92e-04	-3.88e-01	1.16e-03
Cyclin A/B1/B2 associated events during G2/M transition	24	9.88e-04	-3.88e-01	3.42e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs	68	3.01e-08	-3.88e-01	3.06e-07
RNA Polymerase I Transcription Termination	27	4.89e-04	-3.87e-01	1.83e-03
Neurotoxicity of clostridium toxins	10	3.38e-02	-3.87e-01	6.74e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	21	2.11e-03	-3.87e-01	6.77e-03
Nuclear events mediated by NFE2L2	76	5.22e-09	-3.87e-01	6.59e-08
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	3.97e-04	-3.87e-01	1.54e-03
eNOS activation	11	2.64e-02	-3.87e-01	5.57e-02
GLI3 is processed to GLI3R by the proteasome	58	3.51e-07	-3.86e-01	2.69e-06
Formation of the Early Elongation Complex	32	1.54e-04	-3.86e-01	6.59e-04
Formation of the HIV-1 Early Elongation Complex	32	1.54e-04	-3.86e-01	6.59e-04
rRNA processing	186	1.06e-19	-3.85e-01	5.76e-18
FOXO-mediated transcription of cell death genes	15	1.02e-02	-3.83e-01	2.54e-02
TP53 Regulates Transcription of Cell Cycle Genes	49	3.46e-06	-3.83e-01	2.11e-05
Signaling by FGFR2 in disease	42	1.73e-05	-3.83e-01	9.17e-05
Defective CFTR causes cystic fibrosis	59	3.60e-07	-3.83e-01	2.73e-06
Formation of the cornified envelope	74	1.42e-08	3.81e-01	1.52e-07
Transcription of the HIV genome	62	2.14e-07	-3.81e-01	1.76e-06
APC/C-mediated degradation of cell cycle proteins	86	1.03e-09	-3.80e-01	1.51e-08
Regulation of mitotic cell cycle	86	1.03e-09	-3.80e-01	1.51e-08
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	2.00e-04	-3.80e-01	8.24e-04
NIK–>noncanonical NF-kB signaling	57	7.09e-07	-3.79e-01	5.11e-06
Orc1 removal from chromatin	69	5.01e-08	-3.79e-01	4.84e-07
Dual incision in TC-NER	63	1.93e-07	-3.79e-01	1.60e-06
Regulation of APC/C activators between G1/S and early anaphase	79	5.63e-09	-3.79e-01	7.00e-08
B-WICH complex positively regulates rRNA expression	29	4.11e-04	-3.79e-01	1.57e-03
NoRC negatively regulates rRNA expression	43	1.72e-05	-3.79e-01	9.17e-05
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	1.98e-06	-3.77e-01	1.29e-05
Translesion synthesis by POLI	17	7.16e-03	-3.77e-01	1.90e-02
Regulation of RAS by GAPs	66	1.21e-07	-3.76e-01	1.05e-06
GABA synthesis, release, reuptake and degradation	19	4.64e-03	-3.75e-01	1.31e-02
Formation of RNA Pol II elongation complex	53	2.33e-06	-3.75e-01	1.48e-05
RNA Polymerase II Transcription Elongation	53	2.33e-06	-3.75e-01	1.48e-05
Synthesis of glycosylphosphatidylinositol (GPI)	17	7.47e-03	-3.75e-01	1.97e-02
Regulation of Complement cascade	45	1.39e-05	3.74e-01	7.49e-05
Heme biosynthesis	13	1.95e-02	-3.74e-01	4.42e-02
G1/S Transition	126	3.96e-13	-3.74e-01	8.76e-12
Stabilization of p53	55	1.66e-06	-3.73e-01	1.11e-05
IRE1alpha activates chaperones	50	5.47e-06	-3.71e-01	3.14e-05
RIP-mediated NFkB activation via ZBP1	16	1.01e-02	-3.71e-01	2.53e-02
Diseases of programmed cell death	41	3.89e-05	-3.71e-01	1.92e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	5.09e-08	-3.71e-01	4.86e-07
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	22	2.60e-03	-3.71e-01	8.05e-03
Neurodegenerative Diseases	22	2.60e-03	-3.71e-01	8.05e-03
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	62	4.35e-07	-3.71e-01	3.26e-06
Activation of ATR in response to replication stress	37	9.76e-05	-3.70e-01	4.39e-04
Signaling by ROBO receptors	203	9.58e-20	-3.70e-01	5.42e-18
Signaling by NTRK1 (TRKA)	114	9.67e-12	-3.69e-01	1.80e-10
HDR through Single Strand Annealing (SSA)	36	1.30e-04	-3.68e-01	5.65e-04
Cellular response to hypoxia	71	8.16e-08	-3.68e-01	7.51e-07
Assembly of the pre-replicative complex	82	8.30e-09	-3.68e-01	9.61e-08
Unwinding of DNA	12	2.74e-02	-3.68e-01	5.73e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	2.74e-02	-3.68e-01	5.73e-02
alpha-linolenic acid (ALA) metabolism	12	2.74e-02	-3.68e-01	5.73e-02
Regulation of RUNX2 expression and activity	71	8.68e-08	-3.67e-01	7.94e-07
G2/M Checkpoints	129	5.72e-13	-3.67e-01	1.23e-11
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	95	6.63e-10	-3.66e-01	1.00e-08
SARS-CoV-2 modulates host translation machinery	46	1.74e-05	-3.66e-01	9.19e-05
mRNA Editing	10	4.52e-02	3.66e-01	8.28e-02
Telomere Maintenance	62	6.31e-07	-3.66e-01	4.57e-06
Metabolism of Angiotensinogen to Angiotensins	15	1.45e-02	3.64e-01	3.45e-02
Respiratory electron transport	90	2.52e-09	-3.63e-01	3.38e-08
Activation of SMO	17	9.55e-03	-3.63e-01	2.41e-02
UCH proteinases	81	1.69e-08	-3.62e-01	1.77e-07
RMTs methylate histone arginines	29	7.54e-04	-3.61e-01	2.66e-03
RNA Polymerase II Pre-transcription Events	73	1.00e-07	-3.60e-01	8.96e-07
Mitotic G1 phase and G1/S transition	144	7.95e-14	-3.60e-01	2.06e-12
Dectin-2 family	28	9.69e-04	3.60e-01	3.37e-03
TICAM1, RIP1-mediated IKK complex recruitment	18	8.20e-03	-3.60e-01	2.09e-02
Fertilization	26	1.49e-03	3.60e-01	4.93e-03
Degradation of GLI1 by the proteasome	58	2.19e-06	-3.59e-01	1.42e-05
KSRP (KHSRP) binds and destabilizes mRNA	17	1.03e-02	-3.59e-01	2.58e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	1.60e-02	-3.59e-01	3.71e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	1.60e-02	-3.59e-01	3.71e-02
Regulation of TP53 Activity through Phosphorylation	88	5.70e-09	-3.59e-01	7.02e-08
Degradation of GLI2 by the proteasome	58	2.28e-06	-3.59e-01	1.47e-05
Condensation of Prophase Chromosomes	12	3.16e-02	-3.58e-01	6.41e-02
Degradation of DVL	55	4.61e-06	-3.57e-01	2.69e-05
Gap-filling DNA repair synthesis and ligation in TC-NER	62	1.15e-06	-3.57e-01	8.00e-06
p75NTR recruits signalling complexes	12	3.24e-02	-3.56e-01	6.55e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	32	4.80e-04	-3.56e-01	1.80e-03
DNA Replication Pre-Initiation	97	1.29e-09	-3.56e-01	1.81e-08
Processing and activation of SUMO	10	5.13e-02	-3.56e-01	9.15e-02
Cellular response to starvation	147	9.34e-14	-3.55e-01	2.31e-12
Processing of DNA double-strand break ends	61	1.61e-06	-3.55e-01	1.09e-05
PCP/CE pathway	90	5.98e-09	-3.54e-01	7.31e-08
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	2.69e-02	-3.54e-01	5.68e-02
Polo-like kinase mediated events	16	1.42e-02	-3.54e-01	3.38e-02
Glutathione synthesis and recycling	13	2.70e-02	-3.54e-01	5.69e-02
Switching of origins to a post-replicative state	90	6.44e-09	-3.54e-01	7.81e-08
Mitochondrial iron-sulfur cluster biogenesis	12	3.40e-02	-3.53e-01	6.76e-02
G2/M DNA damage checkpoint	58	3.30e-06	-3.53e-01	2.04e-05
mRNA Splicing - Minor Pathway	53	8.77e-06	-3.53e-01	4.89e-05
Viral Messenger RNA Synthesis	42	7.95e-05	-3.52e-01	3.65e-04
Diseases of DNA repair	49	2.05e-05	-3.52e-01	1.06e-04
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.18e-07	-3.51e-01	1.04e-06
ZBP1(DAI) mediated induction of type I IFNs	20	6.61e-03	-3.51e-01	1.78e-02
G0 and Early G1	27	1.62e-03	-3.50e-01	5.34e-03
tRNA processing in the nucleus	55	6.92e-06	-3.50e-01	3.92e-05
TICAM1-dependent activation of IRF3/IRF7	12	3.57e-02	-3.50e-01	7.01e-02
Purine salvage	12	3.59e-02	-3.50e-01	7.04e-02
Separation of Sister Chromatids	161	1.98e-14	-3.49e-01	5.49e-13
RUNX2 regulates bone development	29	1.14e-03	-3.49e-01	3.87e-03
Polymerase switching on the C-strand of the telomere	24	3.08e-03	-3.49e-01	9.31e-03
Josephin domain DUBs	11	4.55e-02	-3.48e-01	8.32e-02
Formation of Incision Complex in GG-NER	40	1.38e-04	-3.48e-01	5.93e-04
RNA polymerase II transcribes snRNA genes	77	1.26e-07	-3.48e-01	1.10e-06
Transcriptional regulation by small RNAs	46	4.65e-05	-3.47e-01	2.24e-04
Translesion synthesis by REV1	16	1.64e-02	-3.46e-01	3.80e-02
Transcriptional regulation by RUNX3	93	7.83e-09	-3.46e-01	9.14e-08
RHO GTPases Activate Formins	114	1.68e-10	-3.46e-01	2.76e-09
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	1.85e-04	-3.46e-01	7.69e-04
Diseases of DNA Double-Strand Break Repair	39	1.85e-04	-3.46e-01	7.69e-04
Negative regulation of MAPK pathway	41	1.28e-04	-3.46e-01	5.57e-04
Cell Cycle Checkpoints	248	6.34e-21	-3.45e-01	4.04e-19
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	2.07e-02	3.45e-01	4.61e-02
Leading Strand Synthesis	13	3.13e-02	-3.45e-01	6.39e-02
Polymerase switching	13	3.13e-02	-3.45e-01	6.39e-02
p75NTR signals via NF-kB	15	2.08e-02	-3.45e-01	4.63e-02
Cross-presentation of soluble exogenous antigens (endosomes)	48	3.63e-05	-3.44e-01	1.80e-04
Defective GALNT12 causes CRCS1	18	1.15e-02	3.44e-01	2.84e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	87	3.13e-08	-3.43e-01	3.17e-07
MET receptor recycling	10	6.04e-02	-3.43e-01	1.05e-01
PI-3K cascade:FGFR3	17	1.44e-02	-3.43e-01	3.42e-02
Cleavage of the damaged purine	11	4.97e-02	-3.42e-01	8.95e-02
Depurination	11	4.97e-02	-3.42e-01	8.95e-02
Recognition and association of DNA glycosylase with site containing an affected purine	11	4.97e-02	-3.42e-01	8.95e-02
PINK1-PRKN Mediated Mitophagy	21	6.74e-03	-3.41e-01	1.81e-02
DNA Replication	125	4.23e-11	-3.41e-01	7.43e-10
Recycling of bile acids and salts	18	1.23e-02	3.41e-01	2.99e-02
RNA Polymerase III Transcription Initiation	36	4.05e-04	-3.40e-01	1.55e-03
Norepinephrine Neurotransmitter Release Cycle	16	1.84e-02	-3.40e-01	4.21e-02
Dectin-1 mediated noncanonical NF-kB signaling	60	5.25e-06	-3.40e-01	3.04e-05
Chromosome Maintenance	86	5.12e-08	-3.39e-01	4.86e-07
Presynaptic phase of homologous DNA pairing and strand exchange	38	3.04e-04	-3.38e-01	1.20e-03
Signaling by PDGFRA extracellular domain mutants	12	4.25e-02	-3.38e-01	7.94e-02
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	4.25e-02	-3.38e-01	7.94e-02
RNA Polymerase III Abortive And Retractive Initiation	41	1.79e-04	-3.38e-01	7.50e-04
RNA Polymerase III Transcription	41	1.79e-04	-3.38e-01	7.50e-04
Sensory Perception	576	4.80e-44	3.38e-01	9.17e-42
DARPP-32 events	24	4.16e-03	-3.38e-01	1.21e-02
EPH-ephrin mediated repulsion of cells	48	5.12e-05	-3.38e-01	2.45e-04
NF-kB is activated and signals survival	12	4.35e-02	-3.36e-01	8.06e-02
PRC2 methylates histones and DNA	13	3.62e-02	-3.35e-01	7.08e-02
Transcriptional regulation by RUNX2	116	4.19e-10	-3.35e-01	6.47e-09
Nucleotide Excision Repair	107	1.99e-09	-3.35e-01	2.74e-08
Defects in cobalamin (B12) metabolism	12	4.43e-02	-3.35e-01	8.18e-02
Recognition of DNA damage by PCNA-containing replication complex	29	1.78e-03	-3.35e-01	5.80e-03
PI-3K cascade:FGFR4	19	1.14e-02	-3.35e-01	2.83e-02
G1/S-Specific Transcription	28	2.16e-03	-3.35e-01	6.90e-03
Cytosolic sensors of pathogen-associated DNA	60	7.23e-06	-3.35e-01	4.05e-05
Cleavage of the damaged pyrimidine	16	2.06e-02	-3.34e-01	4.60e-02
Depyrimidination	16	2.06e-02	-3.34e-01	4.60e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	2.06e-02	-3.34e-01	4.60e-02
Synthesis of DNA	118	3.50e-10	-3.34e-01	5.57e-09
Glucuronidation	25	3.84e-03	3.34e-01	1.13e-02
Homologous DNA Pairing and Strand Exchange	41	2.17e-04	-3.34e-01	8.92e-04
BBSome-mediated cargo-targeting to cilium	23	5.61e-03	-3.33e-01	1.55e-02
Activation of NF-kappaB in B cells	64	3.94e-06	-3.33e-01	2.34e-05
Repression of WNT target genes	13	3.74e-02	-3.33e-01	7.24e-02
Resolution of Sister Chromatid Cohesion	98	1.23e-08	-3.33e-01	1.36e-07
Regulation of pyruvate dehydrogenase (PDH) complex	14	3.13e-02	-3.32e-01	6.39e-02
TCF dependent signaling in response to WNT	168	1.11e-13	-3.32e-01	2.65e-12
Signaling by NTRKs	133	3.96e-11	-3.31e-01	7.03e-10
Signaling by FGFR2	72	1.19e-06	-3.31e-01	8.19e-06
Eicosanoids	12	4.72e-02	3.31e-01	8.59e-02
Metabolism of RNA	638	1.93e-46	-3.30e-01	4.21e-44
Estrogen-dependent gene expression	91	5.04e-08	-3.30e-01	4.84e-07
Golgi Cisternae Pericentriolar Stack Reorganization	14	3.27e-02	-3.30e-01	6.59e-02
Mitochondrial tRNA aminoacylation	18	1.60e-02	-3.28e-01	3.71e-02
Regulation of PTEN stability and activity	66	4.27e-06	-3.27e-01	2.53e-05
FCERI mediated NF-kB activation	74	1.13e-06	-3.27e-01	7.91e-06
Phospholipase C-mediated cascade; FGFR3	12	4.99e-02	-3.27e-01	8.96e-02
Unfolded Protein Response (UPR)	91	7.59e-08	-3.26e-01	7.07e-07
mRNA Splicing - Major Pathway	173	1.35e-13	-3.26e-01	3.13e-12
VLDLR internalisation and degradation	16	2.43e-02	-3.25e-01	5.24e-02
mRNA Splicing	183	3.12e-14	-3.25e-01	8.36e-13
Killing mechanisms	11	6.20e-02	-3.25e-01	1.07e-01
WNT5:FZD7-mediated leishmania damping	11	6.20e-02	-3.25e-01	1.07e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	89	1.18e-07	-3.25e-01	1.04e-06
Amplification of signal from the kinetochores	89	1.18e-07	-3.25e-01	1.04e-06
Activation of the phototransduction cascade	11	6.31e-02	3.23e-01	1.09e-01
Transport of organic anions	10	7.65e-02	3.23e-01	1.28e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	2.11e-02	-3.23e-01	4.69e-02
HIV Life Cycle	139	4.92e-11	-3.23e-01	8.45e-10
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	1.50e-02	-3.22e-01	3.53e-02
PI-3K cascade:FGFR1	21	1.05e-02	-3.22e-01	2.61e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	34	1.14e-03	-3.22e-01	3.87e-03
S Phase	157	4.60e-12	-3.19e-01	9.37e-11
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	3.23e-02	-3.19e-01	6.52e-02
Phospholipase C-mediated cascade; FGFR4	14	3.89e-02	-3.19e-01	7.45e-02
Telomere C-strand synthesis initiation	11	6.75e-02	-3.18e-01	1.15e-01
Regulation of IFNG signaling	14	3.93e-02	-3.18e-01	7.50e-02
Apoptotic factor-mediated response	17	2.32e-02	-3.18e-01	5.06e-02
tRNA processing	98	5.40e-08	-3.18e-01	5.09e-07
Regulation of PTEN gene transcription	59	2.44e-05	-3.17e-01	1.24e-04
DNA Damage Bypass	46	1.94e-04	-3.17e-01	8.03e-04
Downstream signaling of activated FGFR3	24	7.14e-03	-3.17e-01	1.90e-02
Ub-specific processing proteases	157	7.09e-12	-3.17e-01	1.35e-10
Deactivation of the beta-catenin transactivating complex	39	6.20e-04	-3.17e-01	2.26e-03
Diseases of mitotic cell cycle	37	8.77e-04	-3.16e-01	3.07e-03
Chemokine receptors bind chemokines	56	4.31e-05	3.16e-01	2.08e-04
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	14	4.10e-02	3.15e-01	7.74e-02
Diseases of hemostasis	14	4.10e-02	3.15e-01	7.74e-02
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	44	2.96e-04	-3.15e-01	1.18e-03
Complex I biogenesis	49	1.38e-04	-3.15e-01	5.93e-04
Mitotic Spindle Checkpoint	106	2.20e-08	-3.14e-01	2.28e-07
Hedgehog ‘on’ state	83	7.40e-07	-3.14e-01	5.31e-06
Platelet sensitization by LDL	17	2.51e-02	-3.14e-01	5.38e-02
MAPK6/MAPK4 signaling	89	3.08e-07	-3.14e-01	2.41e-06
Downstream signaling of activated FGFR4	26	5.64e-03	-3.13e-01	1.55e-02
Mitotic Metaphase and Anaphase	222	7.92e-16	-3.13e-01	2.81e-14
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	1.16e-03	-3.13e-01	3.93e-03
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	7.39e-04	3.12e-01	2.62e-03
tRNA Aminoacylation	24	8.11e-03	-3.12e-01	2.07e-02
HIV Infection	216	2.49e-15	-3.12e-01	7.67e-14
Signaling by NOTCH2	32	2.25e-03	-3.12e-01	7.10e-03
Telomere C-strand (Lagging Strand) Synthesis	32	2.26e-03	-3.12e-01	7.10e-03
Aspirin ADME	44	3.48e-04	3.11e-01	1.37e-03
Neurotransmitter release cycle	47	2.22e-04	-3.11e-01	9.06e-04
Mitotic Anaphase	221	1.45e-15	-3.11e-01	4.93e-14
EML4 and NUDC in mitotic spindle formation	93	2.23e-07	-3.10e-01	1.81e-06
Transcriptional regulation of granulopoiesis	31	2.81e-03	-3.10e-01	8.64e-03
Senescence-Associated Secretory Phenotype (SASP)	53	9.45e-05	-3.10e-01	4.26e-04
Downstream signaling events of B Cell Receptor (BCR)	78	2.20e-06	-3.10e-01	1.42e-05
MyD88 cascade initiated on plasma membrane	79	1.93e-06	-3.10e-01	1.27e-05
Toll Like Receptor 10 (TLR10) Cascade	79	1.93e-06	-3.10e-01	1.27e-05
Toll Like Receptor 5 (TLR5) Cascade	79	1.93e-06	-3.10e-01	1.27e-05
Regulation of TNFR1 signaling	32	2.48e-03	-3.09e-01	7.75e-03
Interleukin-27 signaling	11	7.60e-02	-3.09e-01	1.27e-01
Physiological factors	12	6.40e-02	-3.09e-01	1.10e-01
Interleukin-35 Signalling	12	6.43e-02	-3.08e-01	1.10e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	3.46e-03	-3.08e-01	1.03e-02
WNT ligand biogenesis and trafficking	25	7.63e-03	-3.08e-01	2.00e-02
Zinc influx into cells by the SLC39 gene family	10	9.15e-02	-3.08e-01	1.49e-01
DNA Double-Strand Break Repair	130	1.26e-09	-3.08e-01	1.80e-08
Late Phase of HIV Life Cycle	126	2.39e-09	-3.08e-01	3.23e-08
Regulation of FZD by ubiquitination	21	1.49e-02	-3.07e-01	3.52e-02
Regulation of TLR by endogenous ligand	17	2.85e-02	3.07e-01	5.90e-02
IKK complex recruitment mediated by RIP1	22	1.27e-02	-3.07e-01	3.08e-02
Metabolism of nitric oxide: NOS3 activation and regulation	15	3.98e-02	-3.06e-01	7.56e-02
Inactivation of APC/C via direct inhibition of the APC/C complex	21	1.51e-02	-3.06e-01	3.54e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	1.51e-02	-3.06e-01	3.54e-02
Host Interactions of HIV factors	122	5.08e-09	-3.06e-01	6.47e-08
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	9.97e-05	-3.06e-01	4.41e-04
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	9.97e-05	-3.06e-01	4.41e-04
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	9.97e-05	-3.06e-01	4.41e-04
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	9.97e-05	-3.06e-01	4.41e-04
Signaling by NOTCH1 in Cancer	54	9.97e-05	-3.06e-01	4.41e-04
DNA strand elongation	31	3.20e-03	-3.06e-01	9.64e-03
Constitutive Signaling by Overexpressed ERBB2	10	9.52e-02	-3.05e-01	1.54e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	5.73e-02	-3.04e-01	1.00e-01
The citric acid (TCA) cycle and respiratory electron transport	143	3.28e-10	-3.04e-01	5.28e-09
Phospholipase C-mediated cascade: FGFR1	16	3.52e-02	-3.04e-01	6.95e-02
STAT5 activation downstream of FLT3 ITD mutants	10	9.65e-02	-3.03e-01	1.55e-01
LGI-ADAM interactions	14	4.96e-02	-3.03e-01	8.95e-02
Energy dependent regulation of mTOR by LKB1-AMPK	28	5.59e-03	-3.02e-01	1.54e-02
TNFR1-induced proapoptotic signaling	13	5.92e-02	-3.02e-01	1.03e-01
Postmitotic nuclear pore complex (NPC) reformation	26	7.64e-03	-3.02e-01	2.00e-02
Signaling by FGFR	85	1.45e-06	-3.02e-01	1.00e-05
Beta-catenin independent WNT signaling	144	3.85e-10	-3.02e-01	6.06e-09
Processing of Capped Intron-Containing Pre-mRNA	231	2.44e-15	-3.02e-01	7.67e-14
DNA Repair	277	5.38e-18	-3.01e-01	2.42e-16
Assembly Of The HIV Virion	16	3.70e-02	-3.01e-01	7.19e-02
SUMOylation of DNA methylation proteins	16	3.70e-02	-3.01e-01	7.20e-02
Transcriptional regulation of pluripotent stem cells	30	4.31e-03	-3.01e-01	1.24e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	3.16e-02	-3.01e-01	6.41e-02
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	6.06e-02	-3.00e-01	1.05e-01
Interleukin-1 signaling	97	3.09e-07	-3.00e-01	2.41e-06
Dopamine Neurotransmitter Release Cycle	20	2.01e-02	-3.00e-01	4.53e-02
Defective GALNT3 causes HFTC	18	2.74e-02	3.00e-01	5.73e-02
Transcriptional Regulation by E2F6	32	3.28e-03	-3.00e-01	9.84e-03
Serotonin Neurotransmitter Release Cycle	16	3.78e-02	-3.00e-01	7.27e-02
Transcriptional Regulation by TP53	346	9.29e-22	-2.99e-01	6.17e-20
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27	7.19e-03	-2.99e-01	1.90e-02
E3 ubiquitin ligases ubiquitinate target proteins	43	6.97e-04	-2.99e-01	2.49e-03
Free fatty acids regulate insulin secretion	10	1.02e-01	2.98e-01	1.61e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	1.14e-02	-2.98e-01	2.82e-02
Mitotic G2-G2/M phases	178	6.25e-12	-2.98e-01	1.23e-10
Protein ubiquitination	61	5.56e-05	-2.98e-01	2.64e-04
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	2.64e-03	-2.98e-01	8.16e-03
G2/M Transition	176	9.52e-12	-2.97e-01	1.80e-10
HDR through MMEJ (alt-NHEJ)	11	8.83e-02	-2.97e-01	1.45e-01
Mitotic Prometaphase	175	1.21e-11	-2.97e-01	2.23e-10
Resolution of Abasic Sites (AP sites)	37	1.79e-03	-2.97e-01	5.80e-03
TRAF6 mediated NF-kB activation	24	1.19e-02	-2.97e-01	2.91e-02
RNA Polymerase II Transcription Termination	62	5.38e-05	-2.96e-01	2.57e-04
Calnexin/calreticulin cycle	25	1.04e-02	-2.96e-01	2.59e-02
TNF signaling	40	1.19e-03	-2.96e-01	4.01e-03
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	5.89e-03	-2.95e-01	1.62e-02
Toll Like Receptor 3 (TLR3) Cascade	88	1.66e-06	-2.95e-01	1.11e-05
MyD88 dependent cascade initiated on endosome	84	2.88e-06	-2.95e-01	1.79e-05
Toll Like Receptor 7/8 (TLR7/8) Cascade	84	2.88e-06	-2.95e-01	1.79e-05
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	94	7.52e-07	-2.95e-01	5.34e-06
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	1.19e-05	-2.94e-01	6.44e-05
HDR through Homologous Recombination (HRR)	65	4.06e-05	-2.94e-01	1.99e-04
Homology Directed Repair	100	3.74e-07	-2.94e-01	2.83e-06
Base Excision Repair	45	6.61e-04	-2.93e-01	2.39e-03
Intrinsic Pathway of Fibrin Clot Formation	21	2.00e-02	2.93e-01	4.53e-02
NOTCH1 Intracellular Domain Regulates Transcription	44	7.72e-04	-2.93e-01	2.71e-03
APC-Cdc20 mediated degradation of Nek2A	26	9.85e-03	-2.92e-01	2.47e-02
Signaling by WNT	263	3.00e-16	-2.92e-01	1.12e-14
PERK regulates gene expression	32	4.27e-03	-2.92e-01	1.23e-02
Transport of Mature mRNAs Derived from Intronless Transcripts	41	1.22e-03	-2.92e-01	4.10e-03
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	5.04e-02	-2.92e-01	9.02e-02
Deadenylation-dependent mRNA decay	56	1.63e-04	-2.91e-01	6.94e-04
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	8.99e-03	-2.90e-01	2.28e-02
Signaling by FGFR3 in disease	21	2.14e-02	-2.90e-01	4.74e-02
MyD88 deficiency (TLR2/4)	16	4.45e-02	2.90e-01	8.19e-02
FGFR3 mutant receptor activation	11	9.65e-02	-2.89e-01	1.55e-01
Signaling by activated point mutants of FGFR3	11	9.65e-02	-2.89e-01	1.55e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	83	5.14e-06	-2.89e-01	2.99e-05
Loss of Nlp from mitotic centrosomes	65	5.63e-05	-2.89e-01	2.65e-04
Loss of proteins required for interphase microtubule organization from the centrosome	65	5.63e-05	-2.89e-01	2.65e-04
Global Genome Nucleotide Excision Repair (GG-NER)	81	7.00e-06	-2.89e-01	3.95e-05
Removal of the Flap Intermediate from the C-strand	17	3.95e-02	-2.88e-01	7.52e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	2.47e-04	-2.88e-01	9.99e-04
Regulation of beta-cell development	41	1.40e-03	-2.88e-01	4.67e-03
Epigenetic regulation of gene expression	83	5.65e-06	-2.88e-01	3.23e-05
Translesion synthesis by POLK	17	3.99e-02	-2.88e-01	7.56e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	2.59e-02	-2.88e-01	5.52e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	9.87e-02	-2.87e-01	1.58e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	4.02e-02	-2.87e-01	7.60e-02
ER Quality Control Compartment (ERQC)	20	2.62e-02	-2.87e-01	5.56e-02
AURKA Activation by TPX2	68	4.26e-05	-2.87e-01	2.07e-04
Signalling to RAS	20	2.63e-02	-2.87e-01	5.57e-02
Extension of Telomeres	48	5.96e-04	-2.86e-01	2.19e-03
FGFR4 ligand binding and activation	13	7.39e-02	-2.86e-01	1.24e-01
Neddylation	228	8.85e-14	-2.86e-01	2.25e-12
HDACs deacetylate histones	29	7.75e-03	-2.86e-01	2.00e-02
Formation of the beta-catenin:TCF transactivating complex	32	5.23e-03	-2.85e-01	1.46e-02
RET signaling	41	1.61e-03	-2.85e-01	5.30e-03
FGFR2c ligand binding and activation	12	8.77e-02	-2.85e-01	1.44e-01
MASTL Facilitates Mitotic Progression	10	1.19e-01	-2.85e-01	1.82e-01
PCNA-Dependent Long Patch Base Excision Repair	21	2.40e-02	-2.84e-01	5.18e-02
SUMOylation of DNA replication proteins	44	1.10e-03	-2.84e-01	3.75e-03
KEAP1-NFE2L2 pathway	103	6.22e-07	-2.84e-01	4.53e-06
TRAF3-dependent IRF activation pathway	15	5.71e-02	-2.84e-01	1.00e-01
mRNA decay by 3’ to 5’ exoribonuclease	16	5.00e-02	-2.83e-01	8.98e-02
MyD88-independent TLR4 cascade	92	2.69e-06	-2.83e-01	1.69e-05
TRIF(TICAM1)-mediated TLR4 signaling	92	2.69e-06	-2.83e-01	1.69e-05
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	3.77e-02	-2.83e-01	7.27e-02
Dual Incision in GG-NER	39	2.25e-03	-2.83e-01	7.10e-03
ER-Phagosome pathway	87	5.28e-06	-2.82e-01	3.05e-05
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	1.67e-02	2.82e-01	3.86e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	1.48e-02	-2.81e-01	3.51e-02
Cell Cycle, Mitotic	477	4.71e-26	-2.81e-01	4.23e-24
Interactions of Vpr with host cellular proteins	33	5.15e-03	-2.81e-01	1.44e-02
Translesion Synthesis by POLH	19	3.38e-02	-2.81e-01	6.74e-02
PI-3K cascade:FGFR2	22	2.27e-02	-2.80e-01	4.98e-02
Activation of Matrix Metalloproteinases	31	6.89e-03	2.80e-01	1.84e-02
Regulation of PLK1 Activity at G2/M Transition	83	1.00e-05	-2.80e-01	5.52e-05
Protein methylation	16	5.23e-02	-2.80e-01	9.28e-02
M Phase	336	1.02e-18	-2.80e-01	5.38e-17
Regulation of TP53 Activity	154	2.02e-09	-2.80e-01	2.75e-08
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	2.86e-03	-2.79e-01	8.76e-03
Regulation of localization of FOXO transcription factors	11	1.09e-01	2.79e-01	1.69e-01
Regulation of TP53 Expression and Degradation	37	3.26e-03	-2.79e-01	9.80e-03
Glutamate Neurotransmitter Release Cycle	23	2.04e-02	-2.79e-01	4.58e-02
Fatty acids	15	6.18e-02	2.78e-01	1.07e-01
Transport of Mature mRNA Derived from an Intronless Transcript	40	2.35e-03	-2.78e-01	7.38e-03
RIPK1-mediated regulated necrosis	27	1.25e-02	-2.78e-01	3.02e-02
Regulation of necroptotic cell death	27	1.25e-02	-2.78e-01	3.02e-02
Glycogen synthesis	15	6.27e-02	-2.78e-01	1.08e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	2.10e-03	2.77e-01	6.74e-03
Termination of translesion DNA synthesis	31	7.65e-03	-2.77e-01	2.00e-02
Negative regulators of DDX58/IFIH1 signaling	34	5.23e-03	-2.77e-01	1.46e-02
Vpr-mediated nuclear import of PICs	32	6.85e-03	-2.76e-01	1.83e-02
MAPK3 (ERK1) activation	10	1.31e-01	-2.76e-01	1.96e-01
Protein localization	147	7.42e-09	-2.76e-01	8.72e-08
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	9.78e-02	-2.76e-01	1.57e-01
Activated NTRK2 signals through FRS2 and FRS3	11	1.13e-01	-2.76e-01	1.76e-01
Rev-mediated nuclear export of HIV RNA	33	6.12e-03	-2.76e-01	1.67e-02
Formation of tubulin folding intermediates by CCT/TriC	26	1.52e-02	-2.75e-01	3.55e-02
FGFR1 ligand binding and activation	15	6.52e-02	-2.75e-01	1.11e-01
Transcription of E2F targets under negative control by DREAM complex	19	3.80e-02	-2.75e-01	7.31e-02
Downstream signaling of activated FGFR1	31	8.07e-03	-2.75e-01	2.07e-02
Downregulation of TGF-beta receptor signaling	26	1.53e-02	-2.75e-01	3.57e-02
Signaling by WNT in cancer	32	7.16e-03	-2.75e-01	1.90e-02
Deubiquitination	230	6.75e-13	-2.75e-01	1.43e-11
Downstream signal transduction	29	1.05e-02	-2.74e-01	2.61e-02
Removal of the Flap Intermediate	13	8.66e-02	-2.74e-01	1.43e-01
Downstream signaling of activated FGFR2	29	1.05e-02	-2.74e-01	2.61e-02
Deposition of new CENPA-containing nucleosomes at the centromere	26	1.55e-02	-2.74e-01	3.60e-02
Nucleosome assembly	26	1.55e-02	-2.74e-01	3.60e-02
SUMOylation of SUMOylation proteins	33	6.38e-03	-2.74e-01	1.73e-02
COPI-mediated anterograde transport	83	1.57e-05	-2.74e-01	8.47e-05
Retrograde transport at the Trans-Golgi-Network	47	1.16e-03	-2.74e-01	3.92e-03
Defective C1GALT1C1 causes TNPS	18	4.44e-02	2.74e-01	8.18e-02
Regulation of TP53 Degradation	36	4.53e-03	-2.73e-01	1.29e-02
ATF4 activates genes in response to endoplasmic reticulum stress	28	1.23e-02	-2.73e-01	2.99e-02
mRNA 3’-end processing	53	5.77e-04	-2.73e-01	2.12e-03
Zinc transporters	17	5.13e-02	-2.73e-01	9.15e-02
HS-GAG degradation	18	4.50e-02	-2.73e-01	8.27e-02
FGFR3 ligand binding and activation	12	1.02e-01	-2.73e-01	1.61e-01
FGFR3c ligand binding and activation	12	1.02e-01	-2.73e-01	1.61e-01
Cell Cycle	602	1.95e-30	-2.73e-01	1.99e-28
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	6.81e-02	-2.72e-01	1.16e-01
Signaling by NOTCH1	70	8.76e-05	-2.71e-01	3.98e-04
G beta:gamma signalling through BTK	17	5.34e-02	-2.71e-01	9.45e-02
Export of Viral Ribonucleoproteins from Nucleus	31	9.25e-03	-2.70e-01	2.34e-02
Class I peroxisomal membrane protein import	19	4.16e-02	-2.70e-01	7.79e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	4.57e-03	-2.69e-01	1.30e-02
CaMK IV-mediated phosphorylation of CREB	10	1.41e-01	-2.69e-01	2.08e-01
Cytoprotection by HMOX1	58	4.03e-04	-2.68e-01	1.55e-03
LDL clearance	19	4.28e-02	-2.68e-01	7.98e-02
Signaling by NTRK2 (TRKB)	25	2.03e-02	-2.68e-01	4.56e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	8.27e-02	-2.68e-01	1.37e-01
Metabolism of non-coding RNA	50	1.06e-03	-2.68e-01	3.62e-03
snRNP Assembly	50	1.06e-03	-2.68e-01	3.62e-03
DNA Double Strand Break Response	42	2.71e-03	-2.67e-01	8.36e-03
Generic Transcription Pathway	1150	2.20e-53	-2.67e-01	5.60e-51
Cellular responses to stress	683	6.44e-33	-2.67e-01	7.57e-31
DNA Damage Recognition in GG-NER	36	5.54e-03	-2.67e-01	1.53e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	6.48e-02	-2.67e-01	1.11e-01
Uptake and function of anthrax toxins	11	1.26e-01	-2.66e-01	1.90e-01
Lagging Strand Synthesis	19	4.43e-02	-2.66e-01	8.18e-02
SHC-mediated cascade:FGFR4	19	4.45e-02	-2.66e-01	8.19e-02
Mitochondrial biogenesis	69	1.30e-04	-2.66e-01	5.65e-04
Cyclin D associated events in G1	46	1.78e-03	-2.66e-01	5.80e-03
G1 Phase	46	1.78e-03	-2.66e-01	5.80e-03
Common Pathway of Fibrin Clot Formation	21	3.49e-02	2.66e-01	6.89e-02
SHC-mediated cascade:FGFR3	17	5.76e-02	-2.66e-01	1.01e-01
Gluconeogenesis	32	9.26e-03	-2.66e-01	2.34e-02
p38MAPK events	13	9.72e-02	-2.66e-01	1.56e-01
RNA Polymerase II Transcription	1271	7.73e-58	-2.65e-01	5.90e-55
SUMOylation of transcription cofactors	43	2.59e-03	-2.65e-01	8.05e-03
Cellular responses to stimuli	697	4.19e-33	-2.65e-01	5.34e-31
Telomere Extension By Telomerase	22	3.16e-02	-2.65e-01	6.41e-02
MAP kinase activation	58	4.86e-04	-2.65e-01	1.82e-03
trans-Golgi Network Vesicle Budding	67	1.80e-04	-2.64e-01	7.51e-04
Activation of gene expression by SREBF (SREBP)	42	3.02e-03	-2.64e-01	9.15e-03
Interleukin-7 signaling	21	3.60e-02	-2.64e-01	7.05e-02
Thyroxine biosynthesis	10	1.48e-01	2.64e-01	2.17e-01
Hedgehog ‘off’ state	97	7.08e-06	-2.64e-01	3.98e-05
tRNA modification in the nucleus and cytosol	38	4.90e-03	-2.64e-01	1.38e-02
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	23	2.86e-02	-2.64e-01	5.90e-02
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	23	2.86e-02	-2.64e-01	5.90e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	23	2.86e-02	-2.64e-01	5.90e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	23	2.86e-02	-2.64e-01	5.90e-02
Impaired BRCA2 binding to PALB2	23	2.86e-02	-2.64e-01	5.90e-02
Metabolism of folate and pterines	16	6.79e-02	-2.64e-01	1.15e-01
Toll Like Receptor 9 (TLR9) Cascade	88	1.91e-05	-2.63e-01	9.96e-05
Gene expression (Transcription)	1407	2.85e-62	-2.63e-01	4.35e-59
RHO GTPases activate CIT	19	4.73e-02	-2.63e-01	8.60e-02
Interactions of Rev with host cellular proteins	35	7.17e-03	-2.62e-01	1.90e-02
TP53 Regulates Transcription of Death Receptors and Ligands	12	1.15e-01	-2.62e-01	1.78e-01
Golgi Associated Vesicle Biogenesis	51	1.19e-03	-2.62e-01	4.01e-03
Protein folding	96	9.04e-06	-2.62e-01	5.02e-05
Chaperonin-mediated protein folding	90	1.73e-05	-2.62e-01	9.17e-05
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	1.17e-01	-2.61e-01	1.80e-01
G beta:gamma signalling through CDC42	19	4.91e-02	-2.61e-01	8.89e-02
Activation of the pre-replicative complex	31	1.21e-02	-2.60e-01	2.97e-02
SHC-mediated cascade:FGFR1	21	3.90e-02	-2.60e-01	7.45e-02
Downstream TCR signaling	92	1.67e-05	-2.59e-01	8.97e-05
ESR-mediated signaling	160	1.43e-08	-2.59e-01	1.53e-07
Membrane binding and targetting of GAG proteins	14	9.31e-02	-2.59e-01	1.51e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	9.31e-02	-2.59e-01	1.51e-01
Anchoring of the basal body to the plasma membrane	92	1.74e-05	-2.59e-01	9.17e-05
Signaling by FLT3 ITD and TKD mutants	16	7.29e-02	-2.59e-01	1.23e-01
Signaling by TGF-beta Receptor Complex	86	3.27e-05	-2.59e-01	1.63e-04
Positive epigenetic regulation of rRNA expression	43	3.34e-03	-2.59e-01	9.96e-03
Erythrocytes take up carbon dioxide and release oxygen	12	1.21e-01	-2.58e-01	1.84e-01
O2/CO2 exchange in erythrocytes	12	1.21e-01	-2.58e-01	1.84e-01
RNA Polymerase I Transcription	47	2.18e-03	-2.58e-01	6.91e-03
TP53 Regulates Metabolic Genes	83	4.69e-05	-2.58e-01	2.25e-04
Phosphorylation of the APC/C	20	4.55e-02	-2.58e-01	8.32e-02
Synthesis of substrates in N-glycan biosythesis	60	5.39e-04	-2.58e-01	1.99e-03
Apoptosis	164	1.13e-08	-2.58e-01	1.25e-07
EPH-Ephrin signaling	90	2.30e-05	-2.58e-01	1.18e-04
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	41	4.26e-03	-2.58e-01	1.23e-02
Transcriptional regulation of white adipocyte differentiation	81	6.17e-05	-2.57e-01	2.89e-04
Glycosphingolipid metabolism	40	4.87e-03	-2.57e-01	1.37e-02
RHOBTB1 GTPase cycle	22	3.70e-02	-2.57e-01	7.19e-02
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	1.24e-01	-2.56e-01	1.87e-01
SUMOylation of chromatin organization proteins	54	1.11e-03	-2.56e-01	3.79e-03
Meiotic recombination	26	2.36e-02	-2.56e-01	5.13e-02
FRS-mediated FGFR4 signaling	21	4.19e-02	-2.56e-01	7.85e-02
ISG15 antiviral mechanism	71	1.98e-04	-2.55e-01	8.17e-04
ATF6 (ATF6-alpha) activates chaperone genes	10	1.62e-01	-2.55e-01	2.34e-01
Mitophagy	27	2.18e-02	-2.55e-01	4.80e-02
FRS-mediated FGFR3 signaling	19	5.43e-02	-2.55e-01	9.59e-02
EGR2 and SOX10-mediated initiation of Schwann cell myelination	27	2.18e-02	-2.55e-01	4.81e-02
TBC/RABGAPs	42	4.25e-03	-2.55e-01	1.23e-02
SARS-CoV-2 modulates autophagy	11	1.45e-01	-2.54e-01	2.13e-01
Processive synthesis on the C-strand of the telomere	19	5.55e-02	-2.54e-01	9.79e-02
Nervous system development	527	1.75e-23	-2.53e-01	1.41e-21
Negative regulation of FLT3	15	8.97e-02	-2.53e-01	1.46e-01
SUMOylation of RNA binding proteins	45	3.34e-03	-2.53e-01	9.96e-03
Axon guidance	503	2.28e-22	-2.53e-01	1.66e-20
Downregulation of SMAD2/3:SMAD4 transcriptional activity	26	2.62e-02	-2.52e-01	5.56e-02
Antigen processing: Ubiquitination & Proteasome degradation	293	1.10e-13	-2.52e-01	2.65e-12
FRS-mediated FGFR1 signaling	23	3.67e-02	-2.52e-01	7.17e-02
HATs acetylate histones	71	2.49e-04	-2.51e-01	1.00e-03
Phospholipase C-mediated cascade; FGFR2	17	7.32e-02	-2.51e-01	1.23e-01
Incretin synthesis, secretion, and inactivation	23	3.73e-02	-2.51e-01	7.22e-02
Signaling by FGFR1	49	2.41e-03	-2.50e-01	7.56e-03
TNFR2 non-canonical NF-kB pathway	94	2.84e-05	-2.50e-01	1.43e-04
Signaling by PDGFR in disease	20	5.33e-02	-2.49e-01	9.45e-02
Signaling by ALK fusions and activated point mutants	51	2.06e-03	-2.49e-01	6.65e-03
Signaling by ALK in cancer	51	2.06e-03	-2.49e-01	6.65e-03
HDMs demethylate histones	18	6.74e-02	-2.49e-01	1.15e-01
Gap junction degradation	10	1.73e-01	-2.49e-01	2.46e-01
Signaling by TGFB family members	114	4.32e-06	-2.49e-01	2.55e-05
FGFR1c ligand binding and activation	11	1.53e-01	-2.49e-01	2.23e-01
Signaling by activated point mutants of FGFR1	11	1.53e-01	-2.49e-01	2.23e-01
Organelle biogenesis and maintenance	243	2.33e-11	-2.49e-01	4.19e-10
Nonhomologous End-Joining (NHEJ)	32	1.49e-02	-2.48e-01	3.52e-02
Transport of the SLBP Dependant Mature mRNA	34	1.21e-02	-2.48e-01	2.97e-02
Sensory perception of taste	47	3.21e-03	2.48e-01	9.65e-03
Cargo trafficking to the periciliary membrane	49	2.64e-03	-2.48e-01	8.15e-03
Interleukin-2 signaling	11	1.54e-01	-2.48e-01	2.24e-01
Dissolution of Fibrin Clot	13	1.22e-01	2.48e-01	1.84e-01
RNA Polymerase I Promoter Clearance	46	3.61e-03	-2.48e-01	1.07e-02
Selective autophagy	59	9.83e-04	-2.48e-01	3.41e-03
Fc epsilon receptor (FCERI) signaling	126	1.55e-06	-2.48e-01	1.06e-05
Signaling by FGFR4	40	6.72e-03	-2.48e-01	1.80e-02
COPI-dependent Golgi-to-ER retrograde traffic	81	1.17e-04	-2.47e-01	5.17e-04
Diseases of signal transduction by growth factor receptors and second messengers	410	7.43e-18	-2.47e-01	3.24e-16
Intrinsic Pathway for Apoptosis	52	2.09e-03	-2.47e-01	6.71e-03
NEP/NS2 Interacts with the Cellular Export Machinery	30	1.94e-02	-2.46e-01	4.41e-02
Asparagine N-linked glycosylation	278	1.49e-12	-2.46e-01	3.12e-11
TGF-beta receptor signaling activates SMADs	45	4.26e-03	-2.46e-01	1.23e-02
Antiviral mechanism by IFN-stimulated genes	78	1.75e-04	-2.46e-01	7.41e-04
Cytochrome c-mediated apoptotic response	12	1.41e-01	-2.45e-01	2.08e-01
MTOR signalling	40	7.25e-03	-2.45e-01	1.91e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	5.80e-02	-2.45e-01	1.01e-01
Circadian Clock	69	4.66e-04	-2.43e-01	1.75e-03
Cellular Senescence	130	1.63e-06	-2.43e-01	1.10e-05
RHOH GTPase cycle	36	1.15e-02	-2.43e-01	2.84e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	3.55e-02	-2.43e-01	6.98e-02
RND1 GTPase cycle	41	7.14e-03	-2.43e-01	1.90e-02
Cellular response to chemical stress	187	1.02e-08	-2.43e-01	1.16e-07
Signaling by FGFR3	39	8.78e-03	-2.42e-01	2.23e-02
Signaling by NOTCH	183	1.51e-08	-2.42e-01	1.59e-07
Signaling by FGFR in disease	61	1.06e-03	-2.42e-01	3.64e-03
Nucleotide biosynthesis	14	1.18e-01	-2.41e-01	1.81e-01
Interleukin-15 signaling	13	1.33e-01	-2.41e-01	1.98e-01
Ethanol oxidation	12	1.49e-01	2.41e-01	2.18e-01
Presynaptic function of Kainate receptors	21	5.62e-02	-2.41e-01	9.89e-02
Regulation of gene expression in beta cells	21	5.64e-02	-2.40e-01	9.91e-02
Iron uptake and transport	57	1.69e-03	-2.40e-01	5.53e-03
Recruitment of NuMA to mitotic centrosomes	76	2.90e-04	-2.40e-01	1.16e-03
RNA Polymerase I Transcription Initiation	42	7.02e-03	-2.40e-01	1.87e-02
Other interleukin signaling	24	4.15e-02	-2.40e-01	7.79e-02
Transcriptional activation of mitochondrial biogenesis	51	2.99e-03	-2.40e-01	9.09e-03
Activation of AMPK downstream of NMDARs	10	1.88e-01	-2.40e-01	2.63e-01
Cilium Assembly	174	4.45e-08	-2.40e-01	4.33e-07
Class B/2 (Secretin family receptors)	94	5.71e-05	-2.40e-01	2.68e-04
Adrenaline,noradrenaline inhibits insulin secretion	28	2.79e-02	-2.40e-01	5.82e-02
Nuclear Envelope (NE) Reassembly	73	3.90e-04	-2.40e-01	1.52e-03
ABC transporter disorders	75	3.31e-04	-2.40e-01	1.31e-03
ADP signalling through P2Y purinoceptor 12	22	5.18e-02	-2.39e-01	9.21e-02
Interleukin-10 signaling	45	5.47e-03	2.39e-01	1.52e-02
Signaling by FGFR4 in disease	11	1.70e-01	-2.39e-01	2.43e-01
Signaling by Hedgehog	133	1.94e-06	-2.39e-01	1.28e-05
Transcriptional Regulation by MECP2	60	1.38e-03	-2.39e-01	4.61e-03
Oxidative Stress Induced Senescence	66	8.16e-04	-2.38e-01	2.86e-03
Synthesis, secretion, and deacylation of Ghrelin	19	7.33e-02	-2.37e-01	1.23e-01
Heme degradation	16	1.00e-01	2.37e-01	1.60e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	3.37e-03	-2.37e-01	1.00e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	1.94e-01	-2.37e-01	2.69e-01
Transport of Mature Transcript to Cytoplasm	76	3.60e-04	-2.37e-01	1.41e-03
mTORC1-mediated signalling	23	4.97e-02	-2.36e-01	8.95e-02
SUMOylation	164	1.82e-07	-2.36e-01	1.51e-06
Ephrin signaling	17	9.24e-02	-2.36e-01	1.50e-01
G beta:gamma signalling through PLC beta	20	6.89e-02	-2.35e-01	1.17e-01
SUMO E3 ligases SUMOylate target proteins	158	3.44e-07	-2.35e-01	2.64e-06
Androgen biosynthesis	11	1.78e-01	2.34e-01	2.53e-01
SUMOylation of intracellular receptors	29	2.88e-02	-2.34e-01	5.94e-02
Cholesterol biosynthesis	24	4.71e-02	-2.34e-01	8.58e-02
Mitochondrial calcium ion transport	22	5.78e-02	-2.34e-01	1.01e-01
Retrograde neurotrophin signalling	14	1.30e-01	-2.33e-01	1.95e-01
Nephrin family interactions	21	6.40e-02	-2.33e-01	1.10e-01
Miscellaneous transport and binding events	21	6.41e-02	-2.33e-01	1.10e-01
Glycogen breakdown (glycogenolysis)	12	1.62e-01	-2.33e-01	2.34e-01
Activated NOTCH1 Transmits Signal to the Nucleus	31	2.46e-02	-2.33e-01	5.29e-02
Transport of Ribonucleoproteins into the Host Nucleus	30	2.72e-02	-2.33e-01	5.71e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37	1.43e-02	-2.33e-01	3.40e-02
rRNA modification in the nucleus and cytosol	55	2.85e-03	-2.32e-01	8.76e-03
Activation of G protein gated Potassium channels	29	3.03e-02	-2.32e-01	6.20e-02
G protein gated Potassium channels	29	3.03e-02	-2.32e-01	6.20e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	29	3.03e-02	-2.32e-01	6.20e-02
Interleukin-6 signaling	11	1.83e-01	-2.32e-01	2.58e-01
RHO GTPases activate IQGAPs	11	1.83e-01	-2.32e-01	2.58e-01
Nuclear import of Rev protein	32	2.33e-02	-2.32e-01	5.08e-02
CLEC7A (Dectin-1) signaling	96	8.74e-05	-2.32e-01	3.98e-04
Regulation of gene expression by Hypoxia-inducible Factor	11	1.85e-01	-2.31e-01	2.59e-01
Signaling by Erythropoietin	25	4.59e-02	-2.31e-01	8.39e-02
Transport of the SLBP independent Mature mRNA	33	2.19e-02	-2.30e-01	4.83e-02
The phototransduction cascade	32	2.41e-02	2.30e-01	5.20e-02
Mismatch Repair	15	1.23e-01	-2.30e-01	1.87e-01
ER to Golgi Anterograde Transport	134	4.38e-06	-2.30e-01	2.57e-05
TNFR1-induced NFkappaB signaling pathway	22	6.24e-02	-2.29e-01	1.08e-01
Signal attenuation	10	2.09e-01	-2.29e-01	2.87e-01
ATF6 (ATF6-alpha) activates chaperones	11	1.89e-01	-2.29e-01	2.63e-01
RHOBTB GTPase Cycle	34	2.09e-02	-2.29e-01	4.64e-02
Calcitonin-like ligand receptors	10	2.10e-01	-2.29e-01	2.88e-01
Synaptic adhesion-like molecules	19	8.44e-02	-2.29e-01	1.40e-01
Cargo recognition for clathrin-mediated endocytosis	98	9.29e-05	-2.28e-01	4.20e-04
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	1.90e-01	-2.28e-01	2.64e-01
HS-GAG biosynthesis	28	3.68e-02	-2.28e-01	7.18e-02
Signaling by CSF3 (G-CSF)	28	3.71e-02	-2.27e-01	7.20e-02
Nuclear Pore Complex (NPC) Disassembly	34	2.17e-02	-2.27e-01	4.79e-02
Mitotic Prophase	78	5.18e-04	-2.27e-01	1.92e-03
Chromatin modifying enzymes	185	9.54e-08	-2.27e-01	8.63e-07
Chromatin organization	185	9.54e-08	-2.27e-01	8.63e-07
Uptake and actions of bacterial toxins	29	3.42e-02	-2.27e-01	6.80e-02
Metabolism of amino acids and derivatives	345	4.19e-13	-2.27e-01	9.15e-12
Erythropoietin activates RAS	14	1.42e-01	-2.26e-01	2.10e-01
EPHB-mediated forward signaling	34	2.24e-02	-2.26e-01	4.92e-02
Potential therapeutics for SARS	83	3.67e-04	-2.26e-01	1.43e-03
Branched-chain amino acid catabolism	20	8.02e-02	-2.26e-01	1.34e-01
Metabolism of proteins	1774	2.97e-57	-2.26e-01	1.13e-54
Signaling by ERBB2 ECD mutants	15	1.30e-01	-2.26e-01	1.95e-01
Ca2+ pathway	62	2.17e-03	-2.25e-01	6.91e-03
Deadenylation of mRNA	25	5.16e-02	-2.25e-01	9.19e-02
Metal ion SLC transporters	25	5.20e-02	-2.24e-01	9.23e-02
Signaling by Leptin	11	1.98e-01	-2.24e-01	2.73e-01
Centrosome maturation	77	6.68e-04	-2.24e-01	2.40e-03
Recruitment of mitotic centrosome proteins and complexes	77	6.68e-04	-2.24e-01	2.40e-03
Lysosome Vesicle Biogenesis	33	2.61e-02	-2.24e-01	5.55e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	5.79e-02	-2.24e-01	1.01e-01
Resolution of D-Loop Structures	32	2.86e-02	-2.23e-01	5.90e-02
Negative regulation of FGFR4 signaling	30	3.43e-02	-2.23e-01	6.80e-02
Interconversion of nucleotide di- and triphosphates	29	3.76e-02	-2.23e-01	7.25e-02
PTEN Regulation	150	2.44e-06	-2.23e-01	1.54e-05
Defects in vitamin and cofactor metabolism	20	8.46e-02	-2.23e-01	1.40e-01
Signaling by NTRK3 (TRKC)	17	1.12e-01	-2.22e-01	1.75e-01
Interleukin-17 signaling	66	1.79e-03	-2.22e-01	5.80e-03
Negative regulation of FGFR1 signaling	32	2.98e-02	-2.22e-01	6.12e-02
Intra-Golgi and retrograde Golgi-to-ER traffic	181	2.57e-07	-2.22e-01	2.05e-06
Intraflagellar transport	36	2.14e-02	-2.21e-01	4.74e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	20	8.66e-02	-2.21e-01	1.43e-01
Golgi-to-ER retrograde transport	115	4.15e-05	-2.21e-01	2.02e-04
SHC-mediated cascade:FGFR2	22	7.26e-02	-2.21e-01	1.23e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	20	8.75e-02	-2.21e-01	1.44e-01
MECP2 regulates neuronal receptors and channels	17	1.15e-01	-2.21e-01	1.78e-01
Activated point mutants of FGFR2	16	1.27e-01	-2.20e-01	1.91e-01
Toll Like Receptor 4 (TLR4) Cascade	124	2.24e-05	-2.20e-01	1.16e-04
Negative regulation of FGFR3 signaling	28	4.39e-02	-2.20e-01	8.12e-02
AKT phosphorylates targets in the cytosol	14	1.54e-01	-2.20e-01	2.24e-01
HCMV Early Events	55	4.77e-03	-2.20e-01	1.35e-02
Resolution of D-loop Structures through Holliday Junction Intermediates	31	3.43e-02	-2.20e-01	6.80e-02
SUMOylation of DNA damage response and repair proteins	71	1.39e-03	-2.19e-01	4.61e-03
RAB geranylgeranylation	57	4.25e-03	-2.19e-01	1.23e-02
NOTCH4 Intracellular Domain Regulates Transcription	19	9.91e-02	-2.18e-01	1.58e-01
DSCAM interactions	11	2.11e-01	-2.18e-01	2.88e-01
IRAK4 deficiency (TLR2/4)	17	1.20e-01	2.17e-01	1.83e-01
Activation of BH3-only proteins	30	3.97e-02	-2.17e-01	7.55e-02
RHO GTPase Effectors	232	1.31e-08	-2.16e-01	1.43e-07
FRS-mediated FGFR2 signaling	24	6.67e-02	-2.16e-01	1.14e-01
Glucose metabolism	87	4.97e-04	-2.16e-01	1.85e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	4.14e-02	-2.15e-01	7.78e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	4.14e-02	-2.15e-01	7.78e-02
Elastic fibre formation	41	1.72e-02	-2.15e-01	3.96e-02
Glycolysis	68	2.17e-03	-2.15e-01	6.91e-03
Citric acid cycle (TCA cycle)	21	8.86e-02	-2.15e-01	1.45e-01
MAPK1/MAPK3 signaling	271	1.24e-09	-2.14e-01	1.79e-08
Clathrin-mediated endocytosis	135	1.76e-05	-2.14e-01	9.24e-05
Inactivation, recovery and regulation of the phototransduction cascade	31	3.93e-02	2.14e-01	7.50e-02
Processive synthesis on the lagging strand	14	1.66e-01	-2.14e-01	2.39e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	6.49e-02	-2.13e-01	1.11e-01
Prostacyclin signalling through prostacyclin receptor	19	1.09e-01	-2.13e-01	1.69e-01
RAF/MAP kinase cascade	265	2.66e-09	-2.12e-01	3.53e-08
Antigen processing-Cross presentation	102	2.33e-04	-2.11e-01	9.51e-04
Transcriptional regulation by RUNX1	183	8.66e-07	-2.11e-01	6.13e-06
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	94	4.26e-04	-2.10e-01	1.61e-03
Toll Like Receptor 2 (TLR2) Cascade	94	4.26e-04	-2.10e-01	1.61e-03
Toll Like Receptor TLR1:TLR2 Cascade	94	4.26e-04	-2.10e-01	1.61e-03
Toll Like Receptor TLR6:TLR2 Cascade	94	4.26e-04	-2.10e-01	1.61e-03
MAPK family signaling cascades	312	1.62e-10	-2.10e-01	2.68e-09
Class I MHC mediated antigen processing & presentation	363	6.89e-12	-2.09e-01	1.33e-10
Biosynthesis of DHA-derived SPMs	17	1.35e-01	-2.09e-01	2.01e-01
Signaling by NOTCH3	48	1.22e-02	-2.09e-01	2.98e-02
Biosynthesis of specialized proresolving mediators (SPMs)	19	1.16e-01	-2.08e-01	1.79e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	1.79e-01	-2.08e-01	2.53e-01
Interleukin-1 family signaling	134	3.30e-05	-2.08e-01	1.64e-04
Mitochondrial Fatty Acid Beta-Oxidation	35	3.38e-02	-2.07e-01	6.74e-02
Glycogen metabolism	24	7.89e-02	-2.07e-01	1.32e-01
Infectious disease	885	8.48e-26	-2.07e-01	7.20e-24
Programmed Cell Death	192	7.49e-07	-2.07e-01	5.34e-06
TP53 Regulates Transcription of Cell Death Genes	42	2.04e-02	-2.07e-01	4.58e-02
Signaling by the B Cell Receptor (BCR)	105	2.54e-04	-2.06e-01	1.02e-03
NS1 Mediated Effects on Host Pathways	39	2.56e-02	-2.06e-01	5.47e-02
Methylation	14	1.81e-01	-2.06e-01	2.56e-01
Formation of apoptosome	10	2.59e-01	-2.06e-01	3.41e-01
Regulation of the apoptosome activity	10	2.59e-01	-2.06e-01	3.41e-01
TCR signaling	112	1.62e-04	-2.06e-01	6.89e-04
FGFR2 ligand binding and activation	19	1.20e-01	-2.06e-01	1.83e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	1.31e-01	-2.06e-01	1.96e-01
Heparan sulfate/heparin (HS-GAG) metabolism	49	1.28e-02	-2.05e-01	3.10e-02
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	11	2.38e-01	2.05e-01	3.19e-01
Ovarian tumor domain proteases	36	3.29e-02	-2.05e-01	6.60e-02
WNT5A-dependent internalization of FZD4	15	1.69e-01	-2.05e-01	2.43e-01
Voltage gated Potassium channels	42	2.17e-02	-2.05e-01	4.79e-02
Regulation of innate immune responses to cytosolic DNA	14	1.85e-01	-2.05e-01	2.59e-01
Nuclear events stimulated by ALK signaling in cancer	18	1.33e-01	-2.04e-01	1.98e-01
Transport to the Golgi and subsequent modification	165	5.93e-06	-2.04e-01	3.38e-05
RND3 GTPase cycle	41	2.40e-02	-2.04e-01	5.18e-02
RHO GTPases Activate WASPs and WAVEs	34	3.99e-02	-2.03e-01	7.56e-02
RUNX3 regulates NOTCH signaling	13	2.06e-01	-2.02e-01	2.84e-01
Platelet Adhesion to exposed collagen	13	2.07e-01	2.02e-01	2.85e-01
Signaling by Retinoic Acid	41	2.52e-02	-2.02e-01	5.41e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	38	3.21e-02	-2.01e-01	6.49e-02
ABC-family proteins mediated transport	98	6.04e-04	-2.00e-01	2.21e-03
CASP8 activity is inhibited	11	2.50e-01	-2.00e-01	3.32e-01
Dimerization of procaspase-8	11	2.50e-01	-2.00e-01	3.32e-01
Regulation by c-FLIP	11	2.50e-01	-2.00e-01	3.32e-01
PIP3 activates AKT signaling	275	1.08e-08	-2.00e-01	1.20e-07
Processing of SMDT1	15	1.81e-01	-1.99e-01	2.56e-01
Meiosis	56	1.02e-02	-1.98e-01	2.56e-02
Butyrophilin (BTN) family interactions	12	2.36e-01	1.98e-01	3.17e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	67	5.19e-03	-1.97e-01	1.45e-02
Negative regulation of FGFR2 signaling	33	5.01e-02	-1.97e-01	8.98e-02
Plasma lipoprotein clearance	37	3.89e-02	-1.96e-01	7.45e-02
Signaling by Nuclear Receptors	237	2.15e-07	-1.95e-01	1.76e-06
Potassium Channels	102	6.54e-04	-1.95e-01	2.37e-03
Activation of kainate receptors upon glutamate binding	29	6.94e-02	-1.95e-01	1.17e-01
SARS-CoV Infections	339	7.34e-10	-1.94e-01	1.09e-08
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	4.38e-02	-1.94e-01	8.11e-02
Infection with Mycobacterium tuberculosis	26	8.68e-02	-1.94e-01	1.43e-01
Aggrephagy	23	1.07e-01	-1.94e-01	1.68e-01
HCMV Infection	79	2.90e-03	-1.94e-01	8.84e-03
Metallothioneins bind metals	11	2.66e-01	-1.94e-01	3.49e-01
Glycogen storage diseases	14	2.10e-01	-1.93e-01	2.88e-01
Extra-nuclear estrogen signaling	73	4.36e-03	-1.93e-01	1.25e-02
Presynaptic nicotinic acetylcholine receptors	12	2.48e-01	1.93e-01	3.30e-01
Post-translational protein modification	1294	1.02e-31	-1.93e-01	1.11e-29
SARS-CoV-2 Infection	265	6.43e-08	-1.93e-01	6.03e-07
Metabolism of nucleotides	95	1.18e-03	-1.92e-01	3.97e-03
Regulation of HSF1-mediated heat shock response	78	3.34e-03	-1.92e-01	9.96e-03
RAF activation	33	5.61e-02	-1.92e-01	9.88e-02
Response of Mtb to phagocytosis	22	1.19e-01	-1.92e-01	1.82e-01
IL-6-type cytokine receptor ligand interactions	17	1.71e-01	-1.92e-01	2.44e-01
HCMV Late Events	54	1.51e-02	-1.91e-01	3.54e-02
Signaling by Receptor Tyrosine Kinases	492	3.46e-13	-1.91e-01	7.78e-12
Pyruvate metabolism and Citric Acid (TCA) cycle	52	1.79e-02	-1.90e-01	4.10e-02
Caspase-mediated cleavage of cytoskeletal proteins	12	2.56e-01	-1.89e-01	3.38e-01
Inactivation of CSF3 (G-CSF) signaling	23	1.16e-01	-1.89e-01	1.78e-01
Reversible hydration of carbon dioxide	11	2.77e-01	-1.89e-01	3.61e-01
Termination of O-glycan biosynthesis	25	1.01e-01	1.89e-01	1.60e-01
Assembly and cell surface presentation of NMDA receptors	23	1.17e-01	-1.89e-01	1.80e-01
Cellular response to heat stress	95	1.47e-03	-1.89e-01	4.89e-03
Disease	1624	2.42e-37	-1.89e-01	3.70e-35
COPII-mediated vesicle transport	66	8.05e-03	-1.89e-01	2.07e-02
Death Receptor Signalling	129	2.21e-04	-1.88e-01	9.04e-04
Metabolism of amine-derived hormones	17	1.80e-01	1.88e-01	2.55e-01
Ras activation upon Ca2+ influx through NMDA receptor	19	1.57e-01	-1.87e-01	2.28e-01
InlB-mediated entry of Listeria monocytogenes into host cell	14	2.25e-01	-1.87e-01	3.04e-01
Fanconi Anemia Pathway	37	4.88e-02	-1.87e-01	8.85e-02
Platelet homeostasis	85	3.00e-03	-1.86e-01	9.12e-03
Intracellular signaling by second messengers	313	1.45e-08	-1.86e-01	1.53e-07
SUMOylation of ubiquitinylation proteins	37	5.04e-02	-1.86e-01	9.02e-02
Toll-like Receptor Cascades	143	1.24e-04	-1.86e-01	5.41e-04
Elevation of cytosolic Ca2+ levels	16	1.99e-01	-1.86e-01	2.74e-01
RHOV GTPase cycle	36	5.40e-02	-1.85e-01	9.55e-02
G alpha (z) signalling events	48	2.62e-02	-1.85e-01	5.56e-02
Regulation of PTEN mRNA translation	25	1.09e-01	1.85e-01	1.69e-01
RHO GTPases Activate ROCKs	19	1.63e-01	-1.85e-01	2.35e-01
Listeria monocytogenes entry into host cells	19	1.63e-01	-1.85e-01	2.35e-01
Pentose phosphate pathway	12	2.68e-01	-1.84e-01	3.51e-01
Spry regulation of FGF signaling	16	2.02e-01	-1.84e-01	2.78e-01
Translation of Structural Proteins	29	8.72e-02	-1.83e-01	1.44e-01
Intra-Golgi traffic	43	3.75e-02	-1.83e-01	7.25e-02
Synthesis of PC	27	1.01e-01	-1.82e-01	1.60e-01
Cell-extracellular matrix interactions	14	2.38e-01	-1.82e-01	3.19e-01
Activation of GABAB receptors	43	3.89e-02	-1.82e-01	7.45e-02
GABA B receptor activation	43	3.89e-02	-1.82e-01	7.45e-02
Membrane Trafficking	586	4.53e-14	-1.82e-01	1.19e-12
FCERI mediated MAPK activation	29	9.02e-02	-1.82e-01	1.47e-01
Formation of Fibrin Clot (Clotting Cascade)	37	5.59e-02	1.82e-01	9.85e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	1.71e-01	-1.81e-01	2.44e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	1.71e-01	-1.81e-01	2.44e-01
Translocation of ZAP-70 to Immunological synapse	17	1.96e-01	1.81e-01	2.72e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	42	4.28e-02	-1.81e-01	7.98e-02
Interleukin-6 family signaling	24	1.26e-01	-1.80e-01	1.90e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	10	3.24e-01	-1.80e-01	4.10e-01
Acetylcholine binding and downstream events	14	2.43e-01	1.80e-01	3.25e-01
Postsynaptic nicotinic acetylcholine receptors	14	2.43e-01	1.80e-01	3.25e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	12	2.81e-01	-1.80e-01	3.65e-01
RHO GTPases activate KTN1	11	3.02e-01	-1.80e-01	3.88e-01
SARS-CoV-2-host interactions	185	2.49e-05	-1.80e-01	1.26e-04
Interleukin-12 family signaling	54	2.29e-02	-1.79e-01	5.00e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	104	1.81e-03	-1.77e-01	5.85e-03
Sema4D in semaphorin signaling	24	1.34e-01	-1.76e-01	2.00e-01
Syndecan interactions	19	1.83e-01	-1.76e-01	2.58e-01
Signaling by PDGF	52	2.79e-02	-1.76e-01	5.82e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	2.37e-01	1.76e-01	3.19e-01
Budding and maturation of HIV virion	28	1.07e-01	-1.76e-01	1.67e-01
Peroxisomal lipid metabolism	28	1.07e-01	-1.76e-01	1.68e-01
Pyruvate metabolism	29	1.01e-01	-1.76e-01	1.60e-01
Bile acid and bile salt metabolism	45	4.12e-02	1.76e-01	7.76e-02
Peroxisomal protein import	62	1.68e-02	-1.75e-01	3.87e-02
FLT3 Signaling	38	6.14e-02	-1.75e-01	1.06e-01
Apoptotic execution phase	43	4.69e-02	-1.75e-01	8.56e-02
Inwardly rectifying K+ channels	35	7.31e-02	-1.75e-01	1.23e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	2.42e-01	-1.75e-01	3.23e-01
Nuclear Envelope Breakdown	50	3.27e-02	-1.74e-01	6.59e-02
SARS-CoV-1 Infection	51	3.16e-02	-1.74e-01	6.41e-02
Signaling by KIT in disease	20	1.78e-01	-1.74e-01	2.53e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	1.78e-01	-1.74e-01	2.53e-01
Unblocking of NMDA receptors, glutamate binding and activation	19	1.90e-01	-1.74e-01	2.64e-01
The canonical retinoid cycle in rods (twilight vision)	23	1.50e-01	1.73e-01	2.20e-01
Nuclear Receptor transcription pathway	51	3.29e-02	-1.73e-01	6.60e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	1.82e-01	-1.72e-01	2.57e-01
Signalling to ERKs	34	8.17e-02	-1.72e-01	1.36e-01
FLT3 signaling in disease	28	1.16e-01	-1.72e-01	1.78e-01
Sphingolipid metabolism	81	7.52e-03	-1.72e-01	1.97e-02
Metabolism of steroid hormones	33	8.81e-02	1.71e-01	1.45e-01
Signal amplification	33	8.87e-02	-1.71e-01	1.45e-01
Defective B4GALT7 causes EDS, progeroid type	17	2.25e-01	-1.70e-01	3.04e-01
Suppression of phagosomal maturation	13	2.89e-01	-1.70e-01	3.74e-01
Regulation of signaling by CBL	18	2.13e-01	-1.69e-01	2.91e-01
Mitotic Telophase/Cytokinesis	10	3.54e-01	-1.69e-01	4.40e-01
Vitamin D (calciferol) metabolism	12	3.12e-01	-1.68e-01	3.99e-01
Nucleotide salvage	21	1.83e-01	-1.68e-01	2.58e-01
Regulation of TP53 Activity through Association with Co-factors	14	2.78e-01	-1.67e-01	3.63e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	3.37e-01	-1.67e-01	4.24e-01
Synthesis of PIPs at the Golgi membrane	17	2.34e-01	1.67e-01	3.15e-01
Phenylalanine and tyrosine metabolism	10	3.63e-01	1.66e-01	4.50e-01
Signaling by ERBB2 in Cancer	25	1.51e-01	-1.66e-01	2.20e-01
Signaling by ERBB2 KD Mutants	24	1.60e-01	-1.66e-01	2.31e-01
Interleukin-12 signaling	44	5.85e-02	-1.65e-01	1.02e-01
Regulation of MECP2 expression and activity	30	1.20e-01	-1.64e-01	1.83e-01
Response to metal ions	14	2.88e-01	-1.64e-01	3.72e-01
Hormone ligand-binding receptors	13	3.06e-01	1.64e-01	3.92e-01
Synthesis of PIPs at the late endosome membrane	10	3.70e-01	1.64e-01	4.56e-01
Platelet calcium homeostasis	27	1.42e-01	-1.63e-01	2.10e-01
Drug ADME	98	5.28e-03	1.63e-01	1.47e-02
FOXO-mediated transcription	65	2.34e-02	-1.62e-01	5.09e-02
Transferrin endocytosis and recycling	30	1.26e-01	-1.61e-01	1.90e-01
Nicotinate metabolism	29	1.33e-01	1.61e-01	1.98e-01
Vesicle-mediated transport	624	5.61e-12	-1.61e-01	1.11e-10
Caspase activation via Death Receptors in the presence of ligand	16	2.65e-01	-1.61e-01	3.48e-01
p75 NTR receptor-mediated signalling	89	8.65e-03	-1.61e-01	2.20e-02
Molecules associated with elastic fibres	30	1.28e-01	-1.61e-01	1.92e-01
Sema4D induced cell migration and growth-cone collapse	20	2.14e-01	-1.60e-01	2.91e-01
ABC transporters in lipid homeostasis	17	2.52e-01	1.60e-01	3.35e-01
Oncogene Induced Senescence	35	1.01e-01	-1.60e-01	1.60e-01
Thromboxane signalling through TP receptor	24	1.75e-01	-1.60e-01	2.49e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	31	1.24e-01	-1.60e-01	1.87e-01
Macroautophagy	111	3.66e-03	-1.60e-01	1.08e-02
Constitutive Signaling by AKT1 E17K in Cancer	25	1.67e-01	-1.60e-01	2.40e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	1.08e-01	-1.59e-01	1.68e-01
Constitutive Signaling by EGFRvIII	15	2.85e-01	-1.59e-01	3.70e-01
Signaling by EGFRvIII in Cancer	15	2.85e-01	-1.59e-01	3.70e-01
Purine catabolism	17	2.56e-01	-1.59e-01	3.38e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	604	2.13e-11	-1.59e-01	3.88e-10
Defective B3GAT3 causes JDSSDHD	17	2.56e-01	-1.59e-01	3.39e-01
Kinesins	42	7.52e-02	-1.59e-01	1.26e-01
Signaling by Non-Receptor Tyrosine Kinases	55	4.33e-02	-1.57e-01	8.06e-02
Signaling by PTK6	55	4.33e-02	-1.57e-01	8.06e-02
Activation of NMDA receptors and postsynaptic events	69	2.37e-02	-1.57e-01	5.14e-02
COPI-independent Golgi-to-ER retrograde traffic	34	1.12e-01	-1.57e-01	1.75e-01
Signaling by Hippo	19	2.38e-01	-1.56e-01	3.19e-01
Amino acids regulate mTORC1	52	5.13e-02	-1.56e-01	9.15e-02
RHOF GTPase cycle	40	8.84e-02	-1.56e-01	1.45e-01
RHO GTPases activate PKNs	34	1.17e-01	-1.55e-01	1.80e-01
Gene Silencing by RNA	80	1.67e-02	-1.55e-01	3.87e-02
Role of LAT2/NTAL/LAB on calcium mobilization	13	3.34e-01	-1.55e-01	4.20e-01
RHOBTB2 GTPase cycle	22	2.10e-01	-1.54e-01	2.88e-01
Autophagy	125	2.89e-03	-1.54e-01	8.84e-03
FGFR1 mutant receptor activation	30	1.44e-01	-1.54e-01	2.12e-01
Signaling by Rho GTPases	590	1.52e-10	-1.54e-01	2.55e-09
Sensory processing of sound by inner hair cells of the cochlea	62	3.61e-02	-1.54e-01	7.07e-02
Glutathione conjugation	37	1.06e-01	-1.53e-01	1.67e-01
Insulin receptor recycling	25	1.84e-01	-1.53e-01	2.59e-01
Phosphorylation of CD3 and TCR zeta chains	20	2.37e-01	1.53e-01	3.18e-01
A tetrasaccharide linker sequence is required for GAG synthesis	23	2.06e-01	-1.52e-01	2.84e-01
VEGFR2 mediated cell proliferation	19	2.50e-01	-1.52e-01	3.32e-01
Apoptotic cleavage of cellular proteins	35	1.20e-01	-1.52e-01	1.83e-01
Disorders of transmembrane transporters	167	6.97e-04	-1.52e-01	2.49e-03
Visual phototransduction	93	1.14e-02	1.52e-01	2.82e-02
Post-chaperonin tubulin folding pathway	23	2.08e-01	-1.52e-01	2.86e-01
PI3K/AKT Signaling in Cancer	103	7.89e-03	-1.51e-01	2.03e-02
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	1.91e-01	-1.51e-01	2.65e-01
Opioid Signalling	88	1.42e-02	-1.51e-01	3.39e-02
Transcriptional Regulation by VENTX	41	9.44e-02	-1.51e-01	1.52e-01
Acyl chain remodelling of PS	21	2.31e-01	1.51e-01	3.12e-01
IRF3-mediated induction of type I IFN	11	3.87e-01	-1.51e-01	4.73e-01
DCC mediated attractive signaling	14	3.30e-01	1.50e-01	4.16e-01
G beta:gamma signalling through PI3Kgamma	25	1.93e-01	-1.50e-01	2.68e-01
Signaling by FGFR1 in disease	37	1.13e-01	-1.50e-01	1.76e-01
RHOD GTPase cycle	49	7.02e-02	-1.49e-01	1.19e-01
DAP12 signaling	28	1.71e-01	-1.49e-01	2.44e-01
Negative regulation of the PI3K/AKT network	111	6.58e-03	-1.49e-01	1.78e-02
Signal Transduction	2408	1.17e-33	-1.49e-01	1.63e-31
Rab regulation of trafficking	114	5.95e-03	-1.49e-01	1.63e-02
Synthesis of bile acids and bile salts	34	1.38e-01	1.47e-01	2.04e-01
Sialic acid metabolism	33	1.44e-01	-1.47e-01	2.12e-01
Signaling by EGFR	49	7.53e-02	-1.47e-01	1.26e-01
CRMPs in Sema3A signaling	15	3.26e-01	-1.46e-01	4.13e-01
ADP signalling through P2Y purinoceptor 1	25	2.06e-01	-1.46e-01	2.84e-01
Basigin interactions	24	2.16e-01	-1.46e-01	2.94e-01
Chondroitin sulfate/dermatan sulfate metabolism	45	9.24e-02	-1.45e-01	1.50e-01
Downregulation of ERBB2:ERBB3 signaling	13	3.67e-01	-1.45e-01	4.54e-01
Rap1 signalling	16	3.17e-01	-1.44e-01	4.02e-01
Interferon alpha/beta signaling	71	3.53e-02	-1.44e-01	6.97e-02
E2F mediated regulation of DNA replication	20	2.64e-01	-1.44e-01	3.47e-01
PI3K Cascade	43	1.02e-01	-1.44e-01	1.61e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	2.13e-01	-1.44e-01	2.91e-01
Signaling by Insulin receptor	76	3.02e-02	-1.44e-01	6.20e-02
Metabolism of carbohydrates	275	4.08e-05	-1.44e-01	2.00e-04
Metabolism	1967	4.26e-26	-1.43e-01	4.07e-24
cGMP effects	15	3.39e-01	-1.43e-01	4.24e-01
RORA activates gene expression	17	3.11e-01	-1.42e-01	3.97e-01
GPER1 signaling	44	1.03e-01	-1.42e-01	1.63e-01
Tandem pore domain potassium channels	12	3.95e-01	-1.42e-01	4.82e-01
TAK1-dependent IKK and NF-kappa-B activation	25	2.22e-01	-1.41e-01	3.00e-01
Meiotic synapsis	32	1.67e-01	-1.41e-01	2.40e-01
Maturation of nucleoprotein	11	4.18e-01	-1.41e-01	5.05e-01
Signaling by Interleukins	426	5.76e-07	-1.41e-01	4.25e-06
RHOC GTPase cycle	69	4.35e-02	-1.40e-01	8.06e-02
G-protein beta:gamma signalling	30	1.83e-01	-1.40e-01	2.58e-01
Apoptotic cleavage of cell adhesion proteins	11	4.21e-01	-1.40e-01	5.08e-01
Interleukin-37 signaling	21	2.66e-01	-1.40e-01	3.49e-01
Constitutive Signaling by Aberrant PI3K in Cancer	77	3.35e-02	-1.40e-01	6.71e-02
Post NMDA receptor activation events	58	6.59e-02	-1.40e-01	1.12e-01
Nucleotide catabolism	35	1.56e-01	-1.39e-01	2.26e-01
RND2 GTPase cycle	42	1.21e-01	-1.38e-01	1.84e-01
Oncogenic MAPK signaling	76	3.71e-02	-1.38e-01	7.20e-02
Insulin receptor signalling cascade	53	8.22e-02	-1.38e-01	1.37e-01
GABA receptor activation	57	7.23e-02	-1.38e-01	1.22e-01
RAS processing	19	3.00e-01	-1.37e-01	3.86e-01
Pregnenolone biosynthesis	10	4.53e-01	1.37e-01	5.40e-01
Nucleotide-like (purinergic) receptors	13	3.95e-01	1.36e-01	4.82e-01
NOD1/2 Signaling Pathway	29	2.07e-01	-1.35e-01	2.85e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21	2.84e-01	1.35e-01	3.69e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	3.66e-01	-1.35e-01	4.54e-01
Phase 0 - rapid depolarisation	31	1.95e-01	-1.35e-01	2.69e-01
IGF1R signaling cascade	51	9.63e-02	-1.35e-01	1.55e-01
Heme signaling	45	1.19e-01	-1.34e-01	1.82e-01
Cargo concentration in the ER	32	1.88e-01	-1.34e-01	2.63e-01
Neuronal System	371	9.49e-06	-1.34e-01	5.25e-05
Regulation of TP53 Activity through Methylation	18	3.26e-01	-1.34e-01	4.13e-01
NCAM1 interactions	36	1.66e-01	-1.33e-01	2.39e-01
p130Cas linkage to MAPK signaling for integrins	15	3.72e-01	1.33e-01	4.58e-01
GPVI-mediated activation cascade	32	1.93e-01	-1.33e-01	2.68e-01
MET activates RAP1 and RAC1	11	4.46e-01	-1.33e-01	5.33e-01
Long-term potentiation	22	2.81e-01	-1.33e-01	3.65e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	52	9.81e-02	-1.33e-01	1.57e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	120	1.22e-02	1.32e-01	2.98e-02
Miscellaneous substrates	12	4.28e-01	1.32e-01	5.16e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	3.62e-01	-1.32e-01	4.49e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	3.48e-01	-1.31e-01	4.35e-01
Reduction of cytosolic Ca++ levels	11	4.54e-01	-1.30e-01	5.41e-01
IRS-mediated signalling	47	1.22e-01	-1.30e-01	1.85e-01
Synthesis of PIPs at the early endosome membrane	15	3.82e-01	1.30e-01	4.69e-01
Trafficking of GluR2-containing AMPA receptors	15	3.84e-01	1.30e-01	4.71e-01
Receptor Mediated Mitophagy	10	4.79e-01	-1.29e-01	5.65e-01
Peptide hormone biosynthesis	11	4.62e-01	1.28e-01	5.48e-01
Signaling by SCF-KIT	43	1.47e-01	-1.28e-01	2.16e-01
NOTCH3 Intracellular Domain Regulates Transcription	24	2.79e-01	-1.28e-01	3.63e-01
Developmental Biology	1020	5.40e-12	-1.27e-01	1.09e-10
Transmission across Chemical Synapses	237	7.45e-04	-1.27e-01	2.64e-03
Nitric oxide stimulates guanylate cyclase	22	3.03e-01	-1.27e-01	3.89e-01
activated TAK1 mediates p38 MAPK activation	16	3.81e-01	-1.27e-01	4.67e-01
IRS-related events triggered by IGF1R	50	1.26e-01	-1.25e-01	1.90e-01
Synthesis of PIPs at the plasma membrane	48	1.38e-01	-1.24e-01	2.04e-01
Signaling by FLT3 fusion proteins	19	3.51e-01	-1.24e-01	4.37e-01
Synthesis of PE	12	4.59e-01	-1.23e-01	5.46e-01
Signaling by ERBB4	57	1.07e-01	-1.23e-01	1.68e-01
Sensory processing of sound	69	7.68e-02	-1.23e-01	1.28e-01
Vasopressin regulates renal water homeostasis via Aquaporins	42	1.70e-01	-1.22e-01	2.43e-01
Signaling by ERBB2 TMD/JMD mutants	21	3.33e-01	-1.22e-01	4.20e-01
PI3K events in ERBB4 signaling	10	5.05e-01	-1.22e-01	5.89e-01
CLEC7A (Dectin-1) induces NFAT activation	11	4.89e-01	-1.21e-01	5.75e-01
Signaling by BMP	27	2.79e-01	-1.20e-01	3.63e-01
Receptor-type tyrosine-protein phosphatases	16	4.08e-01	-1.19e-01	4.95e-01
Signaling by ERBB2	49	1.50e-01	-1.19e-01	2.20e-01
Vitamin B5 (pantothenate) metabolism	16	4.11e-01	-1.19e-01	4.97e-01
Fatty acid metabolism	167	8.11e-03	-1.19e-01	2.07e-02
Signaling by EGFR in Cancer	25	3.08e-01	-1.18e-01	3.95e-01
Glycosaminoglycan metabolism	116	2.86e-02	-1.18e-01	5.90e-02
Sensory processing of sound by outer hair cells of the cochlea	49	1.55e-01	-1.17e-01	2.26e-01
RHO GTPase cycle	421	3.92e-05	-1.17e-01	1.93e-04
Cytokine Signaling in Immune system	667	2.85e-07	-1.16e-01	2.25e-06
FCGR activation	12	4.87e-01	1.16e-01	5.74e-01
Biotin transport and metabolism	10	5.26e-01	-1.16e-01	6.05e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	112	3.48e-02	-1.15e-01	6.89e-02
Dermatan sulfate biosynthesis	10	5.28e-01	-1.15e-01	6.06e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	5.09e-01	-1.15e-01	5.90e-01
Peptide ligand-binding receptors	190	6.24e-03	1.15e-01	1.70e-02
Regulation of lipid metabolism by PPARalpha	116	3.28e-02	-1.15e-01	6.60e-02
Acyl chain remodelling of PC	26	3.15e-01	1.14e-01	4.01e-01
Cell death signalling via NRAGE, NRIF and NADE	69	1.02e-01	-1.14e-01	1.61e-01
Triglyceride catabolism	23	3.47e-01	-1.13e-01	4.33e-01
CTLA4 inhibitory signaling	21	3.69e-01	-1.13e-01	4.56e-01
Regulation of signaling by NODAL	11	5.18e-01	1.13e-01	5.98e-01
Fatty acyl-CoA biosynthesis	35	2.50e-01	-1.12e-01	3.32e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77	8.83e-02	-1.12e-01	1.45e-01
Interleukin-4 and Interleukin-13 signaling	104	4.78e-02	-1.12e-01	8.67e-02
STING mediated induction of host immune responses	13	4.84e-01	-1.12e-01	5.71e-01
Phase 4 - resting membrane potential	19	3.97e-01	-1.12e-01	4.85e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	4.39e-01	-1.12e-01	5.26e-01
HSF1 activation	27	3.17e-01	-1.11e-01	4.02e-01
Protein-protein interactions at synapses	78	8.93e-02	-1.11e-01	1.46e-01
Pre-NOTCH Expression and Processing	61	1.34e-01	-1.11e-01	1.99e-01
Prolactin receptor signaling	15	4.57e-01	1.11e-01	5.44e-01
ALK mutants bind TKIs	12	5.06e-01	-1.11e-01	5.89e-01
Signaling by NODAL	22	3.69e-01	-1.11e-01	4.55e-01
Semaphorin interactions	61	1.35e-01	-1.11e-01	2.00e-01
GRB2 events in EGFR signaling	13	4.95e-01	1.09e-01	5.79e-01
Reactions specific to the complex N-glycan synthesis pathway	10	5.49e-01	-1.09e-01	6.28e-01
Azathioprine ADME	22	3.75e-01	-1.09e-01	4.61e-01
Regulation of KIT signaling	16	4.50e-01	-1.09e-01	5.37e-01
ERBB2 Activates PTK6 Signaling	13	4.97e-01	1.09e-01	5.81e-01
Paracetamol ADME	30	3.05e-01	1.08e-01	3.91e-01
PPARA activates gene expression	114	4.60e-02	-1.08e-01	8.39e-02
Na+/Cl- dependent neurotransmitter transporters	18	4.28e-01	1.08e-01	5.16e-01
HDL remodeling	10	5.56e-01	-1.08e-01	6.33e-01
Passive transport by Aquaporins	13	5.05e-01	1.07e-01	5.89e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	4.90e-01	-1.07e-01	5.75e-01
Pre-NOTCH Transcription and Translation	45	2.18e-01	-1.06e-01	2.96e-01
CD28 dependent PI3K/Akt signaling	22	3.92e-01	-1.05e-01	4.80e-01
CD28 co-stimulation	32	3.03e-01	-1.05e-01	3.89e-01
VxPx cargo-targeting to cilium	20	4.16e-01	-1.05e-01	5.03e-01
Ketone body metabolism	10	5.66e-01	-1.05e-01	6.43e-01
Scavenging of heme from plasma	12	5.30e-01	1.05e-01	6.08e-01
RAB GEFs exchange GTP for GDP on RABs	83	9.89e-02	-1.05e-01	1.58e-01
CD209 (DC-SIGN) signaling	20	4.18e-01	1.05e-01	5.05e-01
Interaction between L1 and Ankyrins	28	3.38e-01	1.05e-01	4.24e-01
Regulation of RUNX1 Expression and Activity	25	3.66e-01	-1.04e-01	4.54e-01
Generation of second messenger molecules	30	3.23e-01	1.04e-01	4.10e-01
Growth hormone receptor signaling	24	3.78e-01	-1.04e-01	4.65e-01
Adaptive Immune System	711	2.31e-06	-1.04e-01	1.47e-05
Alpha-protein kinase 1 signaling pathway	10	5.70e-01	-1.04e-01	6.47e-01
Eicosanoid ligand-binding receptors	14	5.04e-01	-1.03e-01	5.88e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14	5.08e-01	1.02e-01	5.90e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	2.20e-01	-1.01e-01	2.98e-01
Glucagon-type ligand receptors	33	3.15e-01	-1.01e-01	4.01e-01
RHOJ GTPase cycle	51	2.13e-01	-1.01e-01	2.91e-01
Glucagon signaling in metabolic regulation	33	3.17e-01	-1.01e-01	4.02e-01
Signaling by VEGF	101	8.20e-02	-1.00e-01	1.36e-01
PD-1 signaling	21	4.30e-01	9.94e-02	5.17e-01
Interleukin receptor SHC signaling	24	4.01e-01	-9.91e-02	4.87e-01
Pyroptosis	26	3.83e-01	9.88e-02	4.70e-01
VEGFA-VEGFR2 Pathway	93	9.98e-02	-9.87e-02	1.59e-01
SHC1 events in ERBB4 signaling	14	5.23e-01	-9.86e-02	6.03e-01
PKMTs methylate histone lysines	37	2.99e-01	-9.86e-02	3.86e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	16	4.95e-01	-9.84e-02	5.80e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	5.24e-01	-9.82e-02	6.04e-01
Other semaphorin interactions	18	4.77e-01	9.68e-02	5.64e-01
RA biosynthesis pathway	22	4.34e-01	-9.63e-02	5.21e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	2.86e-01	-9.62e-02	3.71e-01
Diseases of carbohydrate metabolism	30	3.62e-01	-9.62e-02	4.49e-01
Costimulation by the CD28 family	65	1.80e-01	-9.62e-02	2.55e-01
Tryptophan catabolism	12	5.67e-01	9.54e-02	6.44e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	5.69e-01	-9.50e-02	6.45e-01
Defective EXT2 causes exostoses 2	12	5.69e-01	-9.50e-02	6.45e-01
HSF1-dependent transactivation	35	3.31e-01	-9.50e-02	4.17e-01
Metabolism of lipids	696	1.84e-05	-9.50e-02	9.64e-05
Gap junction assembly	18	4.85e-01	9.49e-02	5.72e-01
CaM pathway	33	3.45e-01	-9.49e-02	4.31e-01
Calmodulin induced events	33	3.45e-01	-9.49e-02	4.31e-01
Synthesis of IP3 and IP4 in the cytosol	25	4.14e-01	-9.43e-02	5.01e-01
Signal regulatory protein family interactions	13	5.58e-01	9.37e-02	6.36e-01
Organic anion transporters	10	6.08e-01	-9.37e-02	6.76e-01
Interferon Signaling	194	2.44e-02	-9.36e-02	5.25e-02
Advanced glycosylation endproduct receptor signaling	13	5.60e-01	-9.34e-02	6.37e-01
Regulated Necrosis	53	2.41e-01	-9.31e-02	3.23e-01
Regulation of actin dynamics for phagocytic cup formation	59	2.17e-01	-9.28e-02	2.95e-01
Class A/1 (Rhodopsin-like receptors)	312	4.83e-03	9.26e-02	1.36e-02
Sealing of the nuclear envelope (NE) by ESCRT-III	31	3.72e-01	-9.25e-02	4.58e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	5.81e-01	-9.21e-02	6.54e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	15	5.37e-01	-9.20e-02	6.15e-01
Pre-NOTCH Processing in Golgi	18	4.99e-01	-9.19e-02	5.83e-01
MET activates RAS signaling	11	5.98e-01	-9.17e-02	6.68e-01
Metabolism of vitamins and cofactors	181	3.34e-02	-9.16e-02	6.69e-02
RHO GTPases Activate NADPH Oxidases	22	4.58e-01	9.13e-02	5.45e-01
Metabolic disorders of biological oxidation enzymes	32	3.73e-01	-9.09e-02	4.59e-01
Binding and Uptake of Ligands by Scavenger Receptors	41	3.15e-01	9.06e-02	4.01e-01
PI3K events in ERBB2 signaling	16	5.32e-01	-9.02e-02	6.10e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	6.08e-01	-8.92e-02	6.76e-01
Activation of BAD and translocation to mitochondria	15	5.50e-01	-8.92e-02	6.28e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	38	3.44e-01	-8.86e-02	4.31e-01
NCAM signaling for neurite out-growth	57	2.49e-01	-8.83e-02	3.31e-01
MET activates PTK2 signaling	18	5.18e-01	8.80e-02	5.98e-01
Sphingolipid de novo biosynthesis	41	3.31e-01	-8.78e-02	4.17e-01
NR1H2 and NR1H3-mediated signaling	53	2.70e-01	8.75e-02	3.53e-01
FCGR3A-mediated phagocytosis	57	2.59e-01	-8.64e-02	3.41e-01
Leishmania phagocytosis	57	2.59e-01	-8.64e-02	3.41e-01
Parasite infection	57	2.59e-01	-8.64e-02	3.41e-01
Cardiac conduction	120	1.03e-01	-8.61e-02	1.62e-01
Frs2-mediated activation	12	6.08e-01	-8.54e-02	6.76e-01
Striated Muscle Contraction	33	3.98e-01	8.50e-02	4.85e-01
C-type lectin receptors (CLRs)	137	8.68e-02	-8.47e-02	1.43e-01
CD28 dependent Vav1 pathway	11	6.27e-01	-8.46e-02	6.92e-01
Regulation of TP53 Activity through Acetylation	29	4.33e-01	-8.41e-02	5.19e-01
Cell surface interactions at the vascular wall	129	9.91e-02	8.40e-02	1.58e-01
Diseases of metabolism	234	2.68e-02	-8.39e-02	5.65e-02
Recycling pathway of L1	23	4.90e-01	-8.31e-02	5.75e-01
Prolonged ERK activation events	14	5.94e-01	-8.22e-02	6.65e-01
Ca-dependent events	35	4.01e-01	-8.21e-02	4.87e-01
Aquaporin-mediated transport	51	3.15e-01	-8.14e-02	4.01e-01
Nuclear signaling by ERBB4	32	4.29e-01	-8.07e-02	5.16e-01
EGFR downregulation	30	4.46e-01	-8.04e-02	5.33e-01
Metabolism of water-soluble vitamins and cofactors	118	1.32e-01	-8.01e-02	1.98e-01
G-protein activation	24	4.98e-01	-7.99e-02	5.81e-01
Diseases of glycosylation	137	1.07e-01	-7.96e-02	1.68e-01
SLC transporter disorders	92	1.87e-01	-7.95e-02	2.62e-01
Attenuation phase	25	4.97e-01	-7.84e-02	5.81e-01
Neurexins and neuroligins	52	3.30e-01	-7.81e-02	4.16e-01
DAG and IP3 signaling	39	4.00e-01	-7.79e-02	4.87e-01
Xenobiotics	24	5.12e-01	7.73e-02	5.93e-01
Adenylate cyclase inhibitory pathway	14	6.17e-01	-7.72e-02	6.82e-01
Collagen degradation	39	4.09e-01	7.64e-02	4.95e-01
Fcgamma receptor (FCGR) dependent phagocytosis	82	2.33e-01	-7.62e-02	3.14e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	6.29e-01	-7.45e-02	6.93e-01
Diseases associated with visual transduction	11	6.69e-01	7.44e-02	7.30e-01
Diseases of the neuronal system	11	6.69e-01	7.44e-02	7.30e-01
Retinoid cycle disease events	11	6.69e-01	7.44e-02	7.30e-01
ERBB2 Regulates Cell Motility	15	6.18e-01	-7.44e-02	6.82e-01
Keratan sulfate/keratin metabolism	33	4.59e-01	-7.44e-02	5.46e-01
Plasma lipoprotein assembly, remodeling, and clearance	73	2.72e-01	-7.42e-02	3.56e-01
Scavenging by Class A Receptors	19	5.76e-01	7.40e-02	6.52e-01
Neurotransmitter receptors and postsynaptic signal transmission	175	9.11e-02	-7.40e-02	1.48e-01
O-linked glycosylation of mucins	62	3.14e-01	7.38e-02	4.01e-01
Diseases associated with O-glycosylation of proteins	66	3.00e-01	7.37e-02	3.86e-01
Insulin processing	26	5.15e-01	-7.37e-02	5.96e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	43	4.05e-01	7.34e-02	4.92e-01
Plasma lipoprotein remodeling	32	4.76e-01	7.28e-02	5.63e-01
RHOA GTPase cycle	140	1.40e-01	-7.22e-02	2.07e-01
Plasma lipoprotein assembly	19	5.88e-01	7.18e-02	6.60e-01
Metalloprotease DUBs	19	5.89e-01	-7.16e-02	6.60e-01
Amyloid fiber formation	53	3.68e-01	-7.14e-02	4.55e-01
FCERI mediated Ca+2 mobilization	27	5.24e-01	-7.08e-02	6.04e-01
Phase I - Functionalization of compounds	100	2.24e-01	7.04e-02	3.03e-01
PI Metabolism	79	2.80e-01	-7.03e-02	3.64e-01
Effects of PIP2 hydrolysis	26	5.36e-01	-7.01e-02	6.14e-01
RHOB GTPase cycle	66	3.27e-01	-6.97e-02	4.13e-01
Glyoxylate metabolism and glycine degradation	30	5.15e-01	-6.87e-02	5.96e-01
Signaling by MET	66	3.34e-01	-6.87e-02	4.20e-01
Transport of small molecules	689	2.21e-03	-6.82e-02	7.01e-03
Beta-oxidation of very long chain fatty acids	10	7.09e-01	-6.81e-02	7.67e-01
FCGR3A-mediated IL10 synthesis	37	4.74e-01	6.80e-02	5.62e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	23	5.78e-01	-6.70e-02	6.52e-01
Aflatoxin activation and detoxification	20	6.04e-01	-6.70e-02	6.73e-01
GAB1 signalosome	17	6.34e-01	-6.67e-02	6.97e-01
The role of Nef in HIV-1 replication and disease pathogenesis	27	5.49e-01	-6.66e-02	6.28e-01
Inositol phosphate metabolism	45	4.48e-01	-6.54e-02	5.35e-01
Assembly of active LPL and LIPC lipase complexes	17	6.50e-01	6.35e-02	7.13e-01
Chaperone Mediated Autophagy	19	6.32e-01	-6.35e-02	6.95e-01
Glycerophospholipid biosynthesis	114	2.42e-01	-6.34e-02	3.24e-01
Acyl chain remodelling of PI	16	6.61e-01	6.33e-02	7.23e-01
Neutrophil degranulation	458	2.03e-02	-6.32e-02	4.56e-02
Regulation of insulin secretion	77	3.39e-01	-6.30e-02	4.24e-01
MHC class II antigen presentation	104	2.68e-01	-6.28e-02	3.51e-01
Phospholipid metabolism	192	1.35e-01	-6.25e-02	2.01e-01
Blood group systems biosynthesis	22	6.12e-01	6.24e-02	6.79e-01
Factors involved in megakaryocyte development and platelet production	130	2.25e-01	-6.16e-02	3.04e-01
Platelet activation, signaling and aggregation	246	9.71e-02	-6.13e-02	1.56e-01
Regulation of BACH1 activity	15	6.82e-01	-6.10e-02	7.44e-01
Cell recruitment (pro-inflammatory response)	25	5.98e-01	6.09e-02	6.68e-01
Purinergic signaling in leishmaniasis infection	25	5.98e-01	6.09e-02	6.68e-01
Chylomicron assembly	10	7.40e-01	6.05e-02	7.91e-01
RHO GTPases activate PAKs	19	6.51e-01	-5.99e-02	7.13e-01
Downregulation of ERBB2 signaling	28	5.87e-01	-5.92e-02	6.60e-01
O-linked glycosylation	107	2.90e-01	5.92e-02	3.74e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	5.89e-01	5.89e-02	6.60e-01
RAC2 GTPase cycle	80	3.62e-01	-5.89e-02	4.49e-01
Keratan sulfate degradation	12	7.24e-01	5.88e-02	7.80e-01
Integration of energy metabolism	106	2.97e-01	-5.86e-02	3.83e-01
Netrin-1 signaling	49	4.78e-01	-5.86e-02	5.65e-01
ROS and RNS production in phagocytes	35	5.51e-01	-5.82e-02	6.29e-01
Surfactant metabolism	29	5.88e-01	5.82e-02	6.60e-01
SHC1 events in EGFR signaling	14	7.06e-01	5.81e-02	7.65e-01
Diseases associated with the TLR signaling cascade	29	5.98e-01	5.65e-02	6.68e-01
Diseases of Immune System	29	5.98e-01	5.65e-02	6.68e-01
RHOQ GTPase cycle	57	4.67e-01	-5.57e-02	5.53e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	29	6.05e-01	5.55e-02	6.74e-01
Signaling by high-kinase activity BRAF mutants	32	5.88e-01	5.53e-02	6.60e-01
Nicotinamide salvaging	17	6.97e-01	5.44e-02	7.57e-01
Triglyceride metabolism	36	5.73e-01	-5.42e-02	6.49e-01
G alpha (i) signalling events	306	1.04e-01	5.40e-02	1.63e-01
Detoxification of Reactive Oxygen Species	35	5.81e-01	-5.39e-02	6.54e-01
Organic cation transport	10	7.70e-01	-5.33e-02	8.16e-01
Depolymerisation of the Nuclear Lamina	14	7.30e-01	-5.32e-02	7.85e-01
PKA activation	18	7.01e-01	-5.23e-02	7.60e-01
CS/DS degradation	12	7.56e-01	-5.18e-02	8.04e-01
Thrombin signalling through proteinase activated receptors (PARs)	32	6.13e-01	-5.16e-02	6.79e-01
Assembly of collagen fibrils and other multimeric structures	56	5.07e-01	-5.12e-02	5.89e-01
Signaling by BRAF and RAF1 fusions	60	4.94e-01	-5.10e-02	5.79e-01
Integrin cell surface interactions	66	4.75e-01	-5.08e-02	5.62e-01
Acyl chain remodelling of PG	18	7.09e-01	5.08e-02	7.67e-01
Immune System	1877	2.47e-04	-5.07e-02	9.99e-04
Smooth Muscle Contraction	39	5.84e-01	-5.06e-02	6.57e-01
Amine ligand-binding receptors	41	5.76e-01	-5.05e-02	6.52e-01
Triglyceride biosynthesis	13	7.54e-01	5.02e-02	8.03e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	16	7.28e-01	5.02e-02	7.83e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	7.54e-01	-5.01e-02	8.03e-01
Cellular hexose transport	21	6.92e-01	4.99e-02	7.54e-01
Collagen chain trimerization	42	5.77e-01	4.97e-02	6.52e-01
The NLRP3 inflammasome	16	7.38e-01	-4.84e-02	7.90e-01
RHOU GTPase cycle	37	6.16e-01	-4.77e-02	6.81e-01
Laminin interactions	23	6.93e-01	-4.76e-02	7.54e-01
Trafficking and processing of endosomal TLR	11	7.85e-01	4.76e-02	8.28e-01
Negative regulation of MET activity	20	7.15e-01	-4.72e-02	7.72e-01
Cytochrome P450 - arranged by substrate type	64	5.15e-01	4.70e-02	5.96e-01
PKA-mediated phosphorylation of CREB	19	7.24e-01	-4.68e-02	7.80e-01
PECAM1 interactions	12	7.79e-01	-4.67e-02	8.24e-01
DAP12 interactions	40	6.11e-01	-4.64e-02	6.78e-01
Retinoid metabolism and transport	42	6.14e-01	4.49e-02	6.80e-01
G alpha (12/13) signalling events	74	5.06e-01	-4.47e-02	5.89e-01
Interleukin-2 family signaling	40	6.29e-01	-4.41e-02	6.93e-01
Phase II - Conjugation of compounds	109	4.30e-01	4.38e-02	5.16e-01
Adenylate cyclase activating pathway	10	8.13e-01	4.31e-02	8.52e-01
Cell-Cell communication	112	4.37e-01	-4.24e-02	5.24e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	13	7.91e-01	4.24e-02	8.34e-01
Gastrin-CREB signalling pathway via PKC and MAPK	17	7.66e-01	4.16e-02	8.12e-01
Biological oxidations	216	3.00e-01	4.09e-02	3.86e-01
Pyrimidine catabolism	12	8.10e-01	-4.01e-02	8.50e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	8.27e-01	-3.99e-02	8.60e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	7.58e-01	-3.98e-02	8.05e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	101	4.89e-01	-3.98e-02	5.75e-01
Signal transduction by L1	20	7.59e-01	3.97e-02	8.05e-01
Muscle contraction	186	3.51e-01	-3.96e-02	4.37e-01
Collagen formation	88	5.21e-01	-3.96e-02	6.01e-01
GPCR ligand binding	444	1.53e-01	3.95e-02	2.23e-01
TRP channels	24	7.42e-01	3.88e-02	7.92e-01
RHOG GTPase cycle	69	5.81e-01	-3.84e-02	6.54e-01
L1CAM interactions	92	5.25e-01	-3.84e-02	6.04e-01
G-protein mediated events	52	6.37e-01	-3.79e-02	6.99e-01
MAP2K and MAPK activation	36	6.95e-01	3.77e-02	7.56e-01
Late endosomal microautophagy	32	7.15e-01	-3.72e-02	7.72e-01
Presynaptic depolarization and calcium channel opening	12	8.26e-01	3.67e-02	8.60e-01
GRB2 events in ERBB2 signaling	16	8.01e-01	3.64e-02	8.43e-01
Sema3A PAK dependent Axon repulsion	14	8.18e-01	3.55e-02	8.54e-01
Transport of vitamins, nucleosides, and related molecules	38	7.05e-01	3.54e-02	7.64e-01
Carnitine metabolism	11	8.39e-01	-3.54e-02	8.68e-01
Organic cation/anion/zwitterion transport	15	8.13e-01	3.53e-02	8.52e-01
Cell-cell junction organization	56	6.49e-01	3.51e-02	7.12e-01
Degradation of the extracellular matrix	108	5.28e-01	3.51e-02	6.06e-01
Synthesis of PA	35	7.21e-01	3.48e-02	7.78e-01
Chondroitin sulfate biosynthesis	18	8.01e-01	-3.43e-02	8.43e-01
ECM proteoglycans	55	6.61e-01	3.42e-02	7.23e-01
Adherens junctions interactions	26	7.64e-01	3.40e-02	8.10e-01
PIWI-interacting RNA (piRNA) biogenesis	29	7.51e-01	-3.40e-02	8.02e-01
Lewis blood group biosynthesis	18	8.04e-01	3.38e-02	8.45e-01
GPCR downstream signalling	604	1.61e-01	3.33e-02	2.32e-01
Phase 2 - plateau phase	14	8.29e-01	-3.33e-02	8.60e-01
Metabolism of steroids	148	4.90e-01	-3.29e-02	5.75e-01
Hemostasis	560	1.89e-01	-3.24e-02	2.64e-01
N-glycan antennae elongation in the medial/trans-Golgi	26	7.83e-01	-3.12e-02	8.27e-01
Diseases associated with glycosaminoglycan metabolism	38	7.40e-01	-3.11e-02	7.91e-01
Leishmania infection	245	4.05e-01	-3.08e-02	4.92e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	7.34e-01	-3.06e-02	7.87e-01
Signaling by RAS mutants	41	7.34e-01	-3.06e-02	7.87e-01
Signaling by moderate kinase activity BRAF mutants	41	7.34e-01	-3.06e-02	7.87e-01
Signaling downstream of RAS mutants	41	7.34e-01	-3.06e-02	7.87e-01
RAC3 GTPase cycle	84	6.27e-01	-3.06e-02	6.92e-01
Arachidonic acid metabolism	56	6.93e-01	-3.05e-02	7.54e-01
PKA activation in glucagon signalling	17	8.30e-01	3.00e-02	8.61e-01
MET promotes cell motility	29	7.80e-01	3.00e-02	8.24e-01
Signaling by RAF1 mutants	37	7.52e-01	3.00e-02	8.02e-01
Gap junction trafficking	27	7.90e-01	-2.96e-02	8.33e-01
Ion transport by P-type ATPases	51	7.25e-01	2.85e-02	7.81e-01
Stimuli-sensing channels	96	6.36e-01	2.79e-02	6.99e-01
Endogenous sterols	26	8.07e-01	2.76e-02	8.48e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	117	6.10e-01	2.73e-02	6.77e-01
Assembly of the ORC complex at the origin of replication	10	8.82e-01	-2.70e-02	9.07e-01
Mucopolysaccharidoses	10	8.83e-01	2.68e-02	9.07e-01
SHC1 events in ERBB2 signaling	22	8.28e-01	2.67e-02	8.60e-01
Cytosolic sulfonation of small molecules	23	8.26e-01	2.64e-02	8.60e-01
VEGFR2 mediated vascular permeability	26	8.16e-01	-2.63e-02	8.54e-01
G alpha (s) signalling events	153	5.77e-01	-2.61e-02	6.52e-01
Notch-HLH transcription pathway	24	8.27e-01	-2.58e-02	8.60e-01
Response to elevated platelet cytosolic Ca2+	121	6.25e-01	-2.57e-02	6.90e-01
Regulation of IFNA/IFNB signaling	24	8.28e-01	2.55e-02	8.60e-01
Pyrimidine salvage	10	8.89e-01	-2.54e-02	9.11e-01
Hyaluronan metabolism	17	8.56e-01	-2.54e-02	8.85e-01
Signaling by cytosolic FGFR1 fusion mutants	17	8.57e-01	-2.53e-02	8.85e-01
TRAF6 mediated IRF7 activation	28	8.17e-01	-2.53e-02	8.54e-01
Integrin signaling	27	8.23e-01	-2.48e-02	8.59e-01
Innate Immune System	999	1.87e-01	-2.45e-02	2.62e-01
Sodium/Calcium exchangers	11	8.90e-01	2.40e-02	9.11e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	8.81e-01	2.39e-02	9.07e-01
Interferon gamma signaling	90	6.96e-01	-2.38e-02	7.56e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	10	8.96e-01	-2.38e-02	9.16e-01
G alpha (q) signalling events	206	5.56e-01	2.38e-02	6.33e-01
Myogenesis	29	8.27e-01	-2.35e-02	8.60e-01
NOTCH2 intracellular domain regulates transcription	11	8.95e-01	-2.30e-02	9.15e-01
Gap junction trafficking and regulation	29	8.35e-01	-2.24e-02	8.65e-01
Post-translational protein phosphorylation	100	7.02e-01	-2.21e-02	7.61e-01
N-Glycan antennae elongation	15	8.84e-01	-2.17e-02	9.07e-01
Synthesis of very long-chain fatty acyl-CoAs	23	8.60e-01	-2.13e-02	8.88e-01
Reproduction	82	7.39e-01	-2.13e-02	7.91e-01
Non-integrin membrane-ECM interactions	40	8.17e-01	-2.11e-02	8.54e-01
Lysine catabolism	12	9.01e-01	2.07e-02	9.21e-01
Interleukin-20 family signaling	25	8.67e-01	1.93e-02	8.95e-01
Peptide hormone metabolism	83	7.75e-01	-1.82e-02	8.20e-01
Metabolism of porphyrins	27	8.76e-01	-1.73e-02	9.03e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	9.18e-01	1.72e-02	9.36e-01
Platelet degranulation	116	7.58e-01	-1.66e-02	8.05e-01
Collagen biosynthesis and modifying enzymes	65	8.19e-01	-1.64e-02	8.55e-01
Transport of bile salts and organic acids, metal ions and amine compounds	84	8.04e-01	1.57e-02	8.45e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	9.32e-01	-1.56e-02	9.47e-01
O-glycosylation of TSR domain-containing proteins	37	8.72e-01	1.54e-02	8.99e-01
Serotonin receptors	11	9.34e-01	-1.44e-02	9.48e-01
Bicarbonate transporters	10	9.40e-01	1.37e-02	9.52e-01
Ion channel transport	168	7.62e-01	1.35e-02	8.08e-01
Metabolism of fat-soluble vitamins	46	8.82e-01	-1.26e-02	9.07e-01
Ion homeostasis	50	8.81e-01	-1.22e-02	9.07e-01
Aspartate and asparagine metabolism	12	9.42e-01	1.22e-02	9.53e-01
Acyl chain remodelling of PE	24	9.21e-01	1.18e-02	9.38e-01
Post-translational modification: synthesis of GPI-anchored proteins	90	8.48e-01	-1.17e-02	8.77e-01
Inflammasomes	21	9.28e-01	-1.14e-02	9.43e-01
Tie2 Signaling	18	9.35e-01	-1.11e-02	9.48e-01
CYP2E1 reactions	11	9.54e-01	-1.01e-02	9.63e-01
Cell junction organization	79	8.87e-01	-9.22e-03	9.10e-01
Role of phospholipids in phagocytosis	23	9.40e-01	9.07e-03	9.52e-01
SLC-mediated transmembrane transport	238	8.12e-01	-8.93e-03	8.52e-01
Keratan sulfate biosynthesis	28	9.35e-01	8.86e-03	9.48e-01
Platelet Aggregation (Plug Formation)	37	9.26e-01	-8.78e-03	9.42e-01
NRAGE signals death through JNK	53	9.14e-01	8.56e-03	9.33e-01
EPHA-mediated growth cone collapse	15	9.54e-01	-8.51e-03	9.63e-01
Abacavir ADME	10	9.65e-01	8.08e-03	9.71e-01
Signaling by GPCR	671	7.29e-01	7.83e-03	7.84e-01
FGFR2b ligand binding and activation	10	9.69e-01	-7.18e-03	9.74e-01
Tight junction interactions	28	9.49e-01	6.93e-03	9.59e-01
CDC42 GTPase cycle	144	8.88e-01	-6.80e-03	9.10e-01
Amino acid transport across the plasma membrane	30	9.50e-01	-6.57e-03	9.60e-01
TNFs bind their physiological receptors	25	9.57e-01	-6.29e-03	9.64e-01
Chylomicron remodeling	10	9.78e-01	-5.11e-03	9.80e-01
Hyaluronan uptake and degradation	12	9.77e-01	-4.87e-03	9.80e-01
Carboxyterminal post-translational modifications of tubulin	40	9.58e-01	-4.79e-03	9.65e-01
Anti-inflammatory response favouring Leishmania parasite infection	164	9.22e-01	-4.45e-03	9.38e-01
Leishmania parasite growth and survival	164	9.22e-01	-4.45e-03	9.38e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	9.76e-01	-3.25e-03	9.80e-01
Trafficking of AMPA receptors	29	9.76e-01	-3.25e-03	9.80e-01
Activation of RAC1	11	9.86e-01	3.10e-03	9.88e-01
RAC1 GTPase cycle	170	9.49e-01	-2.86e-03	9.59e-01
ADORA2B mediated anti-inflammatory cytokines production	132	9.74e-01	-1.66e-03	9.79e-01
PLC beta mediated events	47	9.91e-01	-9.32e-04	9.92e-01
Extracellular matrix organization	288	9.90e-01	4.48e-04	9.91e-01
Defective B3GALTL causes PpS	36	1.00e+00	-5.11e-05	1.00e+00

---

Detailed Gene set reports

Digestion of dietary carbohydrate

Digestion of dietary carbohydrate

	318
set	Digestion of dietary carbohydrate
setSize	10
pANOVA	0.000283
s.dist	0.663
p.adjustANOVA	0.00113

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AMY1B	6733.5
AMY1C	6733.5
AMY1A	6733.5
AMY2A	6239.5
LCT	5431.5
CHIA	2744.5
MGAM	1929.5
AMY2B	1661.5
CHIT1	-1300.5
TREH	-8363.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AMY1B	6733.5
AMY1C	6733.5
AMY1A	6733.5
AMY2A	6239.5
LCT	5431.5
CHIA	2744.5
MGAM	1929.5
AMY2B	1661.5
CHIT1	-1300.5
TREH	-8363.5

---

NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus

	781
set	NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize	11
pANOVA	0.000239
s.dist	-0.639
p.adjustANOVA	0.000972

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSENEN	-17203.5
JAG1	-17107.5
YWHAZ	-16547.5
DLL4	-16194.5
NCSTN	-15390.5
NOTCH4	-13867.5
APH1B	-12971.5
PSEN2	-12904.5
ADAM10	-12189.5
APH1A	-10726.5
PSEN1	-10681.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSENEN	-17203.5
JAG1	-17107.5
YWHAZ	-16547.5
DLL4	-16194.5
NCSTN	-15390.5
NOTCH4	-13867.5
APH1B	-12971.5
PSEN2	-12904.5
ADAM10	-12189.5
APH1A	-10726.5
PSEN1	-10681.5

---

Folding of actin by CCT/TriC

Folding of actin by CCT/TriC

	441
set	Folding of actin by CCT/TriC
setSize	10
pANOVA	0.000646
s.dist	-0.623
p.adjustANOVA	0.00235

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACTB	-18830.5
CCT8	-18224.5
CCT7	-17489.5
CCT6A	-16518.5
CCT6B	-16356.5
CCT3	-12958.5
CCT5	-12509.5
CCT4	-11816.5
TCP1	-8963.5
CCT2	-5785.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACTB	-18830.5
CCT8	-18224.5
CCT7	-17489.5
CCT6A	-16518.5
CCT6B	-16356.5
CCT3	-12958.5
CCT5	-12509.5
CCT4	-11816.5
TCP1	-8963.5
CCT2	-5785.5

---

SUMOylation of immune response proteins

SUMOylation of immune response proteins

	1183
set	SUMOylation of immune response proteins
setSize	10
pANOVA	0.000672
s.dist	-0.621
p.adjustANOVA	0.00241

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NFKBIA	-18560.5
NFKB2	-18182.5
PIAS3	-16952.5
TOPORS	-16457.5
SUMO1	-13441.5
IKBKE	-13403.5
PIAS4	-11622.5
SUMO3	-11505.5
UBE2I	-10849.5
RELA	-8224.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NFKBIA	-18560.5
NFKB2	-18182.5
PIAS3	-16952.5
TOPORS	-16457.5
SUMO1	-13441.5
IKBKE	-13403.5
PIAS4	-11622.5
SUMO3	-11505.5
UBE2I	-10849.5
RELA	-8224.5

---

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

	1364
set	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
setSize	14
pANOVA	7.74e-05
s.dist	-0.61
p.adjustANOVA	0.000356

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1B	-18818.5
CCNA1	-18253.5
CCNA2	-17945.5
E2F8	-17914.5
CCNE1	-17507.5
TP53	-16930.5
E2F1	-14115.5
ZNF385A	-13252.5
CDKN1A	-12290.5
PCBP4	-12030.5
CCNE2	-11056.5
E2F7	-10073.5
CDK2	-8162.5
ARID3A	-4496.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1B	-18818.5
CCNA1	-18253.5
CCNA2	-17945.5
E2F8	-17914.5
CCNE1	-17507.5
TP53	-16930.5
E2F1	-14115.5
ZNF385A	-13252.5
CDKN1A	-12290.5
PCBP4	-12030.5
CCNE2	-11056.5
E2F7	-10073.5
CDK2	-8162.5
ARID3A	-4496.5

---

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

	884
set	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
setSize	10
pANOVA	0.00131
s.dist	-0.586
p.adjustANOVA	0.0044

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDX2	-18802.5
GSC	-18500.5
EOMES	-18045.5
SOX2	-17486.5
GATA6	-16693.5
TSC22D1	-15904.5
DKK1	-15897.5
HHEX	-13912.5
POU5F1	-2892.5
NANOG	3421.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDX2	-18802.5
GSC	-18500.5
EOMES	-18045.5
SOX2	-17486.5
GATA6	-16693.5
TSC22D1	-15904.5
DKK1	-15897.5
HHEX	-13912.5
POU5F1	-2892.5
NANOG	3421.5

---

Beta defensins

Beta defensins

	117
set	Beta defensins
setSize	32
pANOVA	3.73e-08
s.dist	0.562
p.adjustANOVA	3.7e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DEFB118	6945.5
DEFB133	6861.5
DEFB123	6856.5
DEFB108B	6821.5
DEFB125	6819.5
DEFB105A	6696.0
CCR2	6416.5
DEFB132	6349.5
DEFB107A	4914.0
TLR1	4839.5
DEFB135	4741.5
DEFB116	4357.5
DEFB129	4356.5
DEFB115	4070.5
CCR6	3909.5
DEFB1	3589.5
DEFB121	2660.5
DEFB131	2597.5
DEFB134	0.5
DEFB114	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DEFB118	6945.5
DEFB133	6861.5
DEFB123	6856.5
DEFB108B	6821.5
DEFB125	6819.5
DEFB105A	6696.0
CCR2	6416.5
DEFB132	6349.5
DEFB107A	4914.0
TLR1	4839.5
DEFB135	4741.5
DEFB116	4357.5
DEFB129	4356.5
DEFB115	4070.5
CCR6	3909.5
DEFB1	3589.5
DEFB121	2660.5
DEFB131	2597.5
DEFB134	0.5
DEFB114	0.5
DEFB106A	0.5
DEFB119	0.5
DEFB113	0.5
DEFB103A	0.5
DEFB110	0.5
DEFB124	-1793.5
DEFB127	-2223.5
DEFB104A	-2981.0
DEFB126	-6683.5
DEFB136	-7790.5
DEFB128	-9437.5
TLR2	-14019.5

---

Defensins

Defensins

	299
set	Defensins
setSize	40
pANOVA	1.27e-09
s.dist	0.554
p.adjustANOVA	1.8e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DEFB118	6945.5
DEFB133	6861.5
DEFB123	6856.5
DEFB108B	6821.5
DEFB125	6819.5
DEFA1	6806.0
DEFB105A	6696.0
CCR2	6416.5
DEFB132	6349.5
DEFA3	6188.5
DEFA4	5007.5
DEFA6	4997.5
DEFB107A	4914.0
TLR1	4839.5
DEFB135	4741.5
DEFB116	4357.5
DEFB129	4356.5
DEFB115	4070.5
CCR6	3909.5
DEFB1	3589.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DEFB118	6945.5
DEFB133	6861.5
DEFB123	6856.5
DEFB108B	6821.5
DEFB125	6819.5
DEFA1	6806.0
DEFB105A	6696.0
CCR2	6416.5
DEFB132	6349.5
DEFA3	6188.5
DEFA4	5007.5
DEFA6	4997.5
DEFB107A	4914.0
TLR1	4839.5
DEFB135	4741.5
DEFB116	4357.5
DEFB129	4356.5
DEFB115	4070.5
CCR6	3909.5
DEFB1	3589.5
DEFB121	2660.5
DEFB131	2597.5
PRSS3	1860.5
DEFB134	0.5
DEFB114	0.5
DEFB106A	0.5
DEFB119	0.5
DEFB113	0.5
DEFB103A	0.5
DEFB110	0.5
DEFA5	-1717.5
DEFB124	-1793.5
DEFB127	-2223.5
DEFB104A	-2981.0
DEFB126	-6683.5
ART1	-7253.5
CD4	-7620.5
DEFB136	-7790.5
DEFB128	-9437.5
TLR2	-14019.5

---

FOXO-mediated transcription of cell cycle genes

FOXO-mediated transcription of cell cycle genes

	426
set	FOXO-mediated transcription of cell cycle genes
setSize	16
pANOVA	0.000137
s.dist	-0.55
p.adjustANOVA	0.000593

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1B	-18818.5
BTG1	-18526.5
FOXG1	-18038.5
KLF4	-17822.5
GADD45A	-16673.5
CCNG2	-16025.5
SMAD4	-15382.5
CAV1	-13724.5
CDKN1A	-12290.5
RBL2	-12143.5
PCBP4	-12030.5
SMAD2	-11205.5
FOXO3	-9161.5
MSTN	-7628.5
FOXO1	-4426.5
SMAD3	-4062.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1B	-18818.5
BTG1	-18526.5
FOXG1	-18038.5
KLF4	-17822.5
GADD45A	-16673.5
CCNG2	-16025.5
SMAD4	-15382.5
CAV1	-13724.5
CDKN1A	-12290.5
RBL2	-12143.5
PCBP4	-12030.5
SMAD2	-11205.5
FOXO3	-9161.5
MSTN	-7628.5
FOXO1	-4426.5
SMAD3	-4062.5

---

Inhibition of DNA recombination at telomere

Inhibition of DNA recombination at telomere

	596
set	Inhibition of DNA recombination at telomere
setSize	20
pANOVA	2.17e-05
s.dist	-0.548
p.adjustANOVA	0.000112

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2D	-18309.5
TERF2IP	-17942.5
POLR2I	-17740.5
POLR2L	-17726.5
TINF2	-17444.5
H2AFX	-16232.5
POLR2A	-15976.5
POLR2B	-15522.5
POLR2F	-15151.5
POLR2C	-14409.5
POLR2E	-13593.5
ACD	-12772.0
POLR2K	-11800.5
POLR2G	-11643.5
DAXX	-11459.5
POLR2H	-10479.5
POT1	-8011.5
POLR2J	-7501.5
TERF1	-7354.5
TERF2	1687.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2D	-18309.5
TERF2IP	-17942.5
POLR2I	-17740.5
POLR2L	-17726.5
TINF2	-17444.5
H2AFX	-16232.5
POLR2A	-15976.5
POLR2B	-15522.5
POLR2F	-15151.5
POLR2C	-14409.5
POLR2E	-13593.5
ACD	-12772.0
POLR2K	-11800.5
POLR2G	-11643.5
DAXX	-11459.5
POLR2H	-10479.5
POT1	-8011.5
POLR2J	-7501.5
TERF1	-7354.5
TERF2	1687.5

---

RNA Polymerase III Chain Elongation

RNA Polymerase III Chain Elongation

	1033
set	RNA Polymerase III Chain Elongation
setSize	18
pANOVA	6.85e-05
s.dist	-0.542
p.adjustANOVA	0.000319

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR3GL	-18027.5
POLR1D	-17806.5
POLR3G	-17746.5
POLR2L	-17726.5
POLR3C	-17638.5
POLR1C	-16177.5
POLR2F	-15151.5
POLR3K	-14090.5
POLR2E	-13593.5
POLR3D	-13450.5
POLR3F	-12646.5
POLR3E	-12120.5
POLR2K	-11800.5
POLR2H	-10479.5
POLR3B	-8734.5
POLR3H	-6909.5
POLR3A	-5679.5
CRCP	-2148.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR3GL	-18027.5
POLR1D	-17806.5
POLR3G	-17746.5
POLR2L	-17726.5
POLR3C	-17638.5
POLR1C	-16177.5
POLR2F	-15151.5
POLR3K	-14090.5
POLR2E	-13593.5
POLR3D	-13450.5
POLR3F	-12646.5
POLR3E	-12120.5
POLR2K	-11800.5
POLR2H	-10479.5
POLR3B	-8734.5
POLR3H	-6909.5
POLR3A	-5679.5
CRCP	-2148.5

---

NGF-stimulated transcription

NGF-stimulated transcription

	773
set	NGF-stimulated transcription
setSize	39
pANOVA	4.66e-09
s.dist	-0.542
p.adjustANOVA	5.99e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDK5R2	-18801.5
EGR3	-18601.5
ASCL1	-18566.5
VGF	-18433.5
EGR1	-18432.5
FOS	-18194.5
JUNB	-18103.5
ID2	-18084.5
CDK5	-17940.5
ID1	-17772.5
F3	-17649.5
JUND	-17563.5
SRF	-17508.5
FOSB	-17264.5
NAB2	-16760.5
ID4	-16729.5
REST	-16639.5
FOSL1	-16624.5
EGR4	-16570.5
DNM2	-16114.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDK5R2	-18801.5
EGR3	-18601.5
ASCL1	-18566.5
VGF	-18433.5
EGR1	-18432.5
FOS	-18194.5
JUNB	-18103.5
ID2	-18084.5
CDK5	-17940.5
ID1	-17772.5
F3	-17649.5
JUND	-17563.5
SRF	-17508.5
FOSB	-17264.5
NAB2	-16760.5
ID4	-16729.5
REST	-16639.5
FOSL1	-16624.5
EGR4	-16570.5
DNM2	-16114.5
LYL1	-15595.5
ID3	-13523.5
ARC	-12641.5
RRAD	-12406.5
TF	-12215.5
CDK5R1	-12140.5
ATF2	-11989.5
TRIB1	-11526.5
EGR2	-10690.5
EP300	-7235.5
SH3GL3	-5853.5
SGK1	-5727.5
NAB1	-5196.5
ATF1	-5191.5
CREB1	-5133.5
MEF2D	-4780.5
TCF12	-4423.5
TPH1	1993.5
CHD4	4355.5

---

ERKs are inactivated

ERKs are inactivated

	375
set	ERKs are inactivated
setSize	13
pANOVA	0.000728
s.dist	-0.541
p.adjustANOVA	0.00259

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DUSP6	-18774.5
PPP2R5D	-18483.5
MAPK7	-18336.5
PPP2CA	-18127.5
PPP2R1A	-17915.5
DUSP7	-17247.5
DUSP4	-16920.5
VRK3	-13660.5
MAPK3	-9406.5
DUSP3	-8451.5
PPP2R1B	-8235.5
MAPK1	-6252.5
PPP2CB	4425.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DUSP6	-18774.5
PPP2R5D	-18483.5
MAPK7	-18336.5
PPP2CA	-18127.5
PPP2R1A	-17915.5
DUSP7	-17247.5
DUSP4	-16920.5
VRK3	-13660.5
MAPK3	-9406.5
DUSP3	-8451.5
PPP2R1B	-8235.5
MAPK1	-6252.5
PPP2CB	4425.5

---

FGFR2 alternative splicing

FGFR2 alternative splicing

	413
set	FGFR2 alternative splicing
setSize	26
pANOVA	3.31e-06
s.dist	-0.527
p.adjustANOVA	2.04e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HNRNPF	-18773.5
NCBP1	-18515.5
POLR2D	-18309.5
POLR2I	-17740.5
POLR2L	-17726.5
GTF2F1	-17225.5
POLR2A	-15976.5
POLR2B	-15522.5
ESRP2	-15498.5
POLR2F	-15151.5
HNRNPH1	-14926.5
POLR2C	-14409.5
POLR2E	-13593.5
HNRNPA1	-12516.5
ESRP1	-12332.5
POLR2K	-11800.5
POLR2G	-11643.5
TIA1	-10678.5
POLR2H	-10479.5
TIAL1	-8923.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HNRNPF	-18773.5
NCBP1	-18515.5
POLR2D	-18309.5
POLR2I	-17740.5
POLR2L	-17726.5
GTF2F1	-17225.5
POLR2A	-15976.5
POLR2B	-15522.5
ESRP2	-15498.5
POLR2F	-15151.5
HNRNPH1	-14926.5
POLR2C	-14409.5
POLR2E	-13593.5
HNRNPA1	-12516.5
ESRP1	-12332.5
POLR2K	-11800.5
POLR2G	-11643.5
TIA1	-10678.5
POLR2H	-10479.5
TIAL1	-8923.5
NCBP2	-7657.5
POLR2J	-7501.5
HNRNPM	-7138.5
PTBP1	-7112.5
GTF2F2	-5589.5
RBFOX2	-3067.5

---

Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs

	955
set	Processing of Intronless Pre-mRNAs
setSize	19
pANOVA	8.77e-05
s.dist	-0.52
p.adjustANOVA	0.000398

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-18515.5
CPSF2	-18423.5
CLP1	-17838.5
CSTF3	-17828.5
CSTF1	-17440.5
PAPOLA	-16164.5
SYMPK	-16069.5
CPSF4	-15873.5
NUDT21	-14925.5
FIP1L1	-14440.5
CPSF3	-14322.5
PCF11	-13532.5
CPSF6	-12966.5
CPSF7	-9384.5
CSTF2T	-9113.5
CPSF1	-8900.5
NCBP2	-7657.5
WDR33	1582.5
PABPN1	2528.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-18515.5
CPSF2	-18423.5
CLP1	-17838.5
CSTF3	-17828.5
CSTF1	-17440.5
PAPOLA	-16164.5
SYMPK	-16069.5
CPSF4	-15873.5
NUDT21	-14925.5
FIP1L1	-14440.5
CPSF3	-14322.5
PCF11	-13532.5
CPSF6	-12966.5
CPSF7	-9384.5
CSTF2T	-9113.5
CPSF1	-8900.5
NCBP2	-7657.5
WDR33	1582.5
PABPN1	2528.5

---

Mitochondrial translation termination

Mitochondrial translation termination

	746
set	Mitochondrial translation termination
setSize	87
pANOVA	1.22e-16
s.dist	-0.513
p.adjustANOVA	4.9e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL41	-18603.5
GFM2	-18507.5
MRPL55	-18331.5
MRPL17	-18326.5
AURKAIP1	-18287.5
OXA1L	-18053.5
MRPS34	-18040.5
MRPS12	-17987.5
MRPL49	-17926.5
MRPL32	-17921.5
MTRF1L	-17869.5
MRPS26	-17733.5
MRPL40	-17713.5
MRPL47	-17449.5
MRPL53	-17302.5
MRPS11	-16872.5
MRPL36	-16731.5
MRPL51	-16690.5
MRPS7	-16544.5
MRPS15	-16439.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL41	-18603.5
GFM2	-18507.5
MRPL55	-18331.5
MRPL17	-18326.5
AURKAIP1	-18287.5
OXA1L	-18053.5
MRPS34	-18040.5
MRPS12	-17987.5
MRPL49	-17926.5
MRPL32	-17921.5
MTRF1L	-17869.5
MRPS26	-17733.5
MRPL40	-17713.5
MRPL47	-17449.5
MRPL53	-17302.5
MRPS11	-16872.5
MRPL36	-16731.5
MRPL51	-16690.5
MRPS7	-16544.5
MRPS15	-16439.5
MRPL38	-16317.5
MRPL54	-16228.5
MRPS30	-16203.5
MRPS2	-15951.5
MRPL18	-15855.5
MRPS9	-15764.5
MRPL13	-15668.5
MRPS16	-15610.5
PTCD3	-15551.5
MRPS24	-15546.5
MRPL12	-15478.5
MRPL37	-15238.5
MRPL46	-15236.5
MRPL30	-15103.5
MRPS18B	-14945.5
MRPS23	-14808.5
MRPL19	-14658.5
MRPL21	-14617.5
MRPL57	-14561.5
MRPL42	-14404.5
MRPL39	-14218.5
MRPL44	-14181.5
MRPL24	-14111.5
MRPS5	-13949.5
CHCHD1	-13909.5
MRPS25	-13529.5
MRPS17	-13398.5
ERAL1	-13033.5
MRPL10	-12913.5
MRPL43	-12898.5
MRPS10	-12828.5
MRRF	-12623.5
MRPL52	-12345.5
MRPS31	-12217.5
MRPL3	-11826.5
MRPS27	-11472.5
MRPS18A	-11164.5
MRPS28	-11160.5
MRPL50	-11107.5
MRPL14	-10783.5
MRPL28	-10682.5
MRPL15	-10341.5
MRPS36	-10151.5
MRPL27	-10068.5
MRPL48	-9815.5
MRPL20	-9542.5
MRPL35	-9444.5
MRPL34	-9390.5
MRPL23	-8484.5
MRPL4	-7942.5
MRPL22	-7754.5
MRPL11	-7211.5
MRPL9	-6922.5
MRPS18C	-6313.5
DAP3	-6191.5
GADD45GIP1	-6005.5
MRPS22	-5610.5
MRPS35	-5500.5
MRPL33	-5275.5
MRPS33	-4697.5
MRPS6	-4246.5
MRPS21	-4210.5
MRPL1	-3123.5
MRPS14	-3030.5
MRPL2	-2181.5
MRPL16	-1482.5
MRPL45	3635.5

---

NRIF signals cell death from the nucleus

NRIF signals cell death from the nucleus

	786
set	NRIF signals cell death from the nucleus
setSize	16
pANOVA	0.000403
s.dist	-0.511
p.adjustANOVA	0.00155

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRAF6	-17513.5
PSENEN	-17203.5
NGFR	-16289.5
ITGB3BP	-16134.5
NCSTN	-15390.5
SQSTM1	-14298.5
RPS27A	-13086.5
APH1B	-12971.5
PSEN2	-12904.5
MAPK8	-11853.5
APH1A	-10726.5
PSEN1	-10681.5
UBB	-9131.5
UBA52	-8709.5
NGF	-6705.5
UBC	-6069.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRAF6	-17513.5
PSENEN	-17203.5
NGFR	-16289.5
ITGB3BP	-16134.5
NCSTN	-15390.5
SQSTM1	-14298.5
RPS27A	-13086.5
APH1B	-12971.5
PSEN2	-12904.5
MAPK8	-11853.5
APH1A	-10726.5
PSEN1	-10681.5
UBB	-9131.5
UBA52	-8709.5
NGF	-6705.5
UBC	-6069.5

---

Mitochondrial translation initiation

Mitochondrial translation initiation

	745
set	Mitochondrial translation initiation
setSize	87
pANOVA	2.01e-16
s.dist	-0.509
p.adjustANOVA	7.68e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL41	-18603.5
MRPL55	-18331.5
MRPL17	-18326.5
MTIF3	-18304.5
AURKAIP1	-18287.5
OXA1L	-18053.5
MRPS34	-18040.5
MRPS12	-17987.5
MRPL49	-17926.5
MRPL32	-17921.5
MRPS26	-17733.5
MRPL40	-17713.5
MRPL47	-17449.5
MRPL53	-17302.5
MTFMT	-17009.5
MRPS11	-16872.5
MRPL36	-16731.5
MRPL51	-16690.5
MRPS7	-16544.5
MRPS15	-16439.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL41	-18603.5
MRPL55	-18331.5
MRPL17	-18326.5
MTIF3	-18304.5
AURKAIP1	-18287.5
OXA1L	-18053.5
MRPS34	-18040.5
MRPS12	-17987.5
MRPL49	-17926.5
MRPL32	-17921.5
MRPS26	-17733.5
MRPL40	-17713.5
MRPL47	-17449.5
MRPL53	-17302.5
MTFMT	-17009.5
MRPS11	-16872.5
MRPL36	-16731.5
MRPL51	-16690.5
MRPS7	-16544.5
MRPS15	-16439.5
MRPL38	-16317.5
MRPL54	-16228.5
MRPS30	-16203.5
MRPS2	-15951.5
MRPL18	-15855.5
MRPS9	-15764.5
MRPL13	-15668.5
MRPS16	-15610.5
PTCD3	-15551.5
MRPS24	-15546.5
MRPL12	-15478.5
MRPL37	-15238.5
MRPL46	-15236.5
MRPL30	-15103.5
MRPS18B	-14945.5
MRPS23	-14808.5
MRPL19	-14658.5
MRPL21	-14617.5
MRPL57	-14561.5
MRPL42	-14404.5
MRPL39	-14218.5
MRPL44	-14181.5
MRPL24	-14111.5
MRPS5	-13949.5
CHCHD1	-13909.5
MRPS25	-13529.5
MRPS17	-13398.5
ERAL1	-13033.5
MRPL10	-12913.5
MRPL43	-12898.5
MRPS10	-12828.5
MRPL52	-12345.5
MRPS31	-12217.5
MRPL3	-11826.5
MRPS27	-11472.5
MRPS18A	-11164.5
MRPS28	-11160.5
MRPL50	-11107.5
MRPL14	-10783.5
MRPL28	-10682.5
MRPL15	-10341.5
MRPS36	-10151.5
MRPL27	-10068.5
MRPL48	-9815.5
MRPL20	-9542.5
MTIF2	-9488.5
MRPL35	-9444.5
MRPL34	-9390.5
MRPL23	-8484.5
MRPL4	-7942.5
MRPL22	-7754.5
MRPL11	-7211.5
MRPL9	-6922.5
MRPS18C	-6313.5
DAP3	-6191.5
GADD45GIP1	-6005.5
MRPS22	-5610.5
MRPS35	-5500.5
MRPL33	-5275.5
MRPS33	-4697.5
MRPS6	-4246.5
MRPS21	-4210.5
MRPL1	-3123.5
MRPS14	-3030.5
MRPL2	-2181.5
MRPL16	-1482.5
MRPL45	3635.5

---

Mitochondrial translation

Mitochondrial translation

	743
set	Mitochondrial translation
setSize	93
pANOVA	2.51e-17
s.dist	-0.507
p.adjustANOVA	1.07e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL41	-18603.5
GFM2	-18507.5
MRPL55	-18331.5
MRPL17	-18326.5
MTIF3	-18304.5
AURKAIP1	-18287.5
OXA1L	-18053.5
MRPS34	-18040.5
MRPS12	-17987.5
MRPL49	-17926.5
MRPL32	-17921.5
MTRF1L	-17869.5
MRPS26	-17733.5
MRPL40	-17713.5
MRPL47	-17449.5
MRPL53	-17302.5
MTFMT	-17009.5
MRPS11	-16872.5
MRPL36	-16731.5
MRPL51	-16690.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL41	-18603.5
GFM2	-18507.5
MRPL55	-18331.5
MRPL17	-18326.5
MTIF3	-18304.5
AURKAIP1	-18287.5
OXA1L	-18053.5
MRPS34	-18040.5
MRPS12	-17987.5
MRPL49	-17926.5
MRPL32	-17921.5
MTRF1L	-17869.5
MRPS26	-17733.5
MRPL40	-17713.5
MRPL47	-17449.5
MRPL53	-17302.5
MTFMT	-17009.5
MRPS11	-16872.5
MRPL36	-16731.5
MRPL51	-16690.5
MRPS7	-16544.5
MRPS15	-16439.5
MRPL38	-16317.5
MRPL54	-16228.5
MRPS30	-16203.5
MRPS2	-15951.5
MRPL18	-15855.5
MRPS9	-15764.5
MRPL13	-15668.5
MRPS16	-15610.5
PTCD3	-15551.5
MRPS24	-15546.5
MRPL12	-15478.5
MRPL37	-15238.5
MRPL46	-15236.5
MRPL30	-15103.5
MRPS18B	-14945.5
MRPS23	-14808.5
MRPL19	-14658.5
MRPL21	-14617.5
GFM1	-14599.5
MRPL57	-14561.5
MRPL42	-14404.5
MRPL39	-14218.5
MRPL44	-14181.5
MRPL24	-14111.5
MRPS5	-13949.5
CHCHD1	-13909.5
MRPS25	-13529.5
MRPS17	-13398.5
ERAL1	-13033.5
MRPL10	-12913.5
MRPL43	-12898.5
MRPS10	-12828.5
MRRF	-12623.5
MRPL52	-12345.5
MRPS31	-12217.5
MRPL3	-11826.5
MRPS27	-11472.5
MRPS18A	-11164.5
MRPS28	-11160.5
MRPL50	-11107.5
TUFM	-11087.5
MRPL14	-10783.5
MRPL28	-10682.5
MRPL15	-10341.5
MRPS36	-10151.5
MRPL27	-10068.5
MRPL48	-9815.5
MRPL20	-9542.5
MTIF2	-9488.5
MRPL35	-9444.5
MRPL34	-9390.5
MRPL23	-8484.5
MRPL4	-7942.5
MRPL22	-7754.5
MRPL11	-7211.5
MRPL9	-6922.5
MRPS18C	-6313.5
DAP3	-6191.5
GADD45GIP1	-6005.5
MRPS22	-5610.5
MRPS35	-5500.5
MRPL33	-5275.5
MRPS33	-4697.5
MRPS6	-4246.5
MRPS21	-4210.5
MRPL1	-3123.5
MRPS14	-3030.5
MRPL2	-2181.5
MRPL16	-1482.5
TSFM	2508.5
MRPL45	3635.5

---

Regulated proteolysis of p75NTR

Regulated proteolysis of p75NTR

	1069
set	Regulated proteolysis of p75NTR
setSize	11
pANOVA	0.00366
s.dist	-0.506
p.adjustANOVA	0.0108

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRAF6	-17513.5
PSENEN	-17203.5
NGFR	-16289.5
NCSTN	-15390.5
APH1B	-12971.5
PSEN2	-12904.5
ADAM17	-12398.5
APH1A	-10726.5
PSEN1	-10681.5
RELA	-8224.5
NFKB1	-2277.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRAF6	-17513.5
PSENEN	-17203.5
NGFR	-16289.5
NCSTN	-15390.5
APH1B	-12971.5
PSEN2	-12904.5
ADAM17	-12398.5
APH1A	-10726.5
PSEN1	-10681.5
RELA	-8224.5
NFKB1	-2277.5

---

Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

	1340
set	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
setSize	12
pANOVA	0.00254
s.dist	-0.503
p.adjustANOVA	0.00792

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SPCS1	-18871.5
PAX6	-18859.5
ISL1	-18671.5
GATA4	-17870.5
SPCS3	-15754.5
SPCS2	-14772.5
SEC11A	-14563.5
PCSK1	-12550.5
DPP4	-9246.5
SEC11C	-6126.5
FFAR1	-2861.5
GIP	1579.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SPCS1	-18871.5
PAX6	-18859.5
ISL1	-18671.5
GATA4	-17870.5
SPCS3	-15754.5
SPCS2	-14772.5
SEC11A	-14563.5
PCSK1	-12550.5
DPP4	-9246.5
SEC11C	-6126.5
FFAR1	-2861.5
GIP	1579.5

---

Crosslinking of collagen fibrils

Crosslinking of collagen fibrils

	243
set	Crosslinking of collagen fibrils
setSize	10
pANOVA	0.00635
s.dist	-0.498
p.adjustANOVA	0.0173

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LOXL3	-18295.5
LOX	-17955.5
TLL1	-16937.5
PCOLCE	-16189.5
TLL2	-16179.5
LOXL1	-12765.5
LOXL4	-8467.5
LOXL2	-8048.5
BMP1	-5953.5
PXDN	-2382.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LOXL3	-18295.5
LOX	-17955.5
TLL1	-16937.5
PCOLCE	-16189.5
TLL2	-16179.5
LOXL1	-12765.5
LOXL4	-8467.5
LOXL2	-8048.5
BMP1	-5953.5
PXDN	-2382.5

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	395
set	Eukaryotic Translation Elongation
setSize	88
pANOVA	6.2e-16
s.dist	-0.498
p.adjustANOVA	2.26e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	-18753.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
RPL10A	-17335.5
EEF1A2	-17299.5
RPL41	-17298.5
EEF1B2	-17296.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	-18753.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
RPL10A	-17335.5
EEF1A2	-17299.5
RPL41	-17298.5
EEF1B2	-17296.5
EEF1D	-17282.5
RPS15	-16904.5
RPL12	-16833.5
RPL39L	-16785.5
RPL36AL	-16745.5
RPL7	-16696.5
RPL26	-16612.5
RPS3A	-16535.5
RPL11	-16448.5
RPL36	-16436.5
RPL18A	-16395.5
RPLP0	-16315.5
RPL17	-16078.5
EEF1A1	-16051.5
EEF1G	-16000.5
RPL14	-15979.5
RPL27	-15955.5
RPL37A	-15628.5
RPS28	-15367.5
RPS25	-15248.5
RPS13	-15062.5
RPS29	-14798.5
RPS18	-14256.5
RPS23	-14233.5
RPS5	-13741.5
RPL30	-13428.5
RPL21	-13384.0
RPL32	-13137.5
RPS27A	-13086.5
RPL37	-13044.5
RPL22	-13022.5
RPL29	-12825.5
RPS27	-12488.5
RPL31	-12397.5
RPL8	-11935.5
RPSA	-11874.5
RPL13A	-11540.0
RPS11	-11531.5
RPS15A	-11448.5
RPS3	-11188.5
RPLP1	-10916.5
RPL23	-10744.5
RPL6	-10548.5
RPL19	-9774.5
RPL5	-9652.5
RPS14	-9097.5
UBA52	-8709.5
RPS26	-8333.5
RPL35A	-7574.5
RPS12	-7221.5
EEF2	-6814.5
RPS20	-6516.5
RPS24	-4512.5
RPS7	-4479.5
RPL7A	-4437.5
RPL24	-4018.5
RPS6	-3673.5
RPL9	-3553.5
RPL3L	-3327.5
RPL38	-2842.5
RPS8	-2717.5
RPS19	-2624.5
RPL10L	-1873.5
RPL4	-1829.5
RPS17	0.5
RPS9	1795.5
RPL34	2134.5
RPL3	3441.5

---

Interaction With Cumulus Cells And The Zona Pellucida

Interaction With Cumulus Cells And The Zona Pellucida

	611
set	Interaction With Cumulus Cells And The Zona Pellucida
setSize	11
pANOVA	0.00431
s.dist	0.497
p.adjustANOVA	0.0124

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADAM30	7198.5
SPAM1	6930.5
ZP3	6686.5
ZP2	5150.5
ADAM21	4835.5
OVGP1	1153.5
ADAM2	-1783.5
ZP4	-3274.5
ADAM20	-3357.5
B4GALT1	-6858.5
ZP1	-9126.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADAM30	7198.5
SPAM1	6930.5
ZP3	6686.5
ZP2	5150.5
ADAM21	4835.5
OVGP1	1153.5
ADAM2	-1783.5
ZP4	-3274.5
ADAM20	-3357.5
B4GALT1	-6858.5
ZP1	-9126.5

---

RUNX3 regulates p14-ARF

RUNX3 regulates p14-ARF

	1052
set	RUNX3 regulates p14-ARF
setSize	10
pANOVA	0.00666
s.dist	-0.495
p.adjustANOVA	0.0179

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BRD2	-18851.5
KRAS	-18783.5
CCND1	-16516.5
RUNX3	-16371.5
CBFB	-16309.5
TGFB1	-15949.5
CDKN2A	-9740.5
EP300	-7235.5
RUNX1	-6157.5
HDAC4	3115.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BRD2	-18851.5
KRAS	-18783.5
CCND1	-16516.5
RUNX3	-16371.5
CBFB	-16309.5
TGFB1	-15949.5
CDKN2A	-9740.5
EP300	-7235.5
RUNX1	-6157.5
HDAC4	3115.5

---

RNA Polymerase III Transcription Termination

RNA Polymerase III Transcription Termination

	1039
set	RNA Polymerase III Transcription Termination
setSize	23
pANOVA	4.15e-05
s.dist	-0.493
p.adjustANOVA	0.000202

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NFIX	-18823.5
POLR3GL	-18027.5
POLR1D	-17806.5
POLR3G	-17746.5
POLR2L	-17726.5
POLR3C	-17638.5
SSB	-16219.5
POLR1C	-16177.5
POLR2F	-15151.5
POLR3K	-14090.5
POLR2E	-13593.5
POLR3D	-13450.5
POLR3F	-12646.5
POLR3E	-12120.5
POLR2K	-11800.5
POLR2H	-10479.5
POLR3B	-8734.5
NFIA	-7144.5
POLR3H	-6909.5
POLR3A	-5679.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NFIX	-18823.5
POLR3GL	-18027.5
POLR1D	-17806.5
POLR3G	-17746.5
POLR2L	-17726.5
POLR3C	-17638.5
SSB	-16219.5
POLR1C	-16177.5
POLR2F	-15151.5
POLR3K	-14090.5
POLR2E	-13593.5
POLR3D	-13450.5
POLR3F	-12646.5
POLR3E	-12120.5
POLR2K	-11800.5
POLR2H	-10479.5
POLR3B	-8734.5
NFIA	-7144.5
POLR3H	-6909.5
POLR3A	-5679.5
NFIC	-5465.5
NFIB	-2239.5
CRCP	-2148.5

---

Processing of Capped Intronless Pre-mRNA

Processing of Capped Intronless Pre-mRNA

	953
set	Processing of Capped Intronless Pre-mRNA
setSize	28
pANOVA	6.68e-06
s.dist	-0.491
p.adjustANOVA	3.79e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-18515.5
CPSF2	-18423.5
CLP1	-17838.5
CSTF3	-17828.5
SNRPG	-17704.5
CSTF1	-17440.5
LSM11	-17116.5
SLBP	-16839.5
PAPOLA	-16164.5
SYMPK	-16069.5
CPSF4	-15873.5
SNRPF	-15579.5
LSM10	-15492.5
NUDT21	-14925.5
SNRPD3	-14590.5
FIP1L1	-14440.5
CPSF3	-14322.5
PCF11	-13532.5
CPSF6	-12966.5
ZNF473	-12112.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-18515.5
CPSF2	-18423.5
CLP1	-17838.5
CSTF3	-17828.5
SNRPG	-17704.5
CSTF1	-17440.5
LSM11	-17116.5
SLBP	-16839.5
PAPOLA	-16164.5
SYMPK	-16069.5
CPSF4	-15873.5
SNRPF	-15579.5
LSM10	-15492.5
NUDT21	-14925.5
SNRPD3	-14590.5
FIP1L1	-14440.5
CPSF3	-14322.5
PCF11	-13532.5
CPSF6	-12966.5
ZNF473	-12112.5
CPSF7	-9384.5
CSTF2T	-9113.5
CPSF1	-8900.5
NCBP2	-7657.5
SNRPE	1334.5
WDR33	1582.5
PABPN1	2528.5
SNRPB	5084.5

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	1172
set	SRP-dependent cotranslational protein targeting to membrane
setSize	105
pANOVA	3.15e-18
s.dist	-0.491
p.adjustANOVA	1.55e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SPCS1	-18871.5
RPS27L	-18753.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
SRP9	-18351.5
SRP14	-18322.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
RPL10A	-17335.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SPCS1	-18871.5
RPS27L	-18753.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
SRP9	-18351.5
SRP14	-18322.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
RPL10A	-17335.5
RPL41	-17298.5
SRP72	-17172.5
RPS15	-16904.5
RPL12	-16833.5
RPL39L	-16785.5
RPL36AL	-16745.5
RPL7	-16696.5
RPL26	-16612.5
RPS3A	-16535.5
RPL11	-16448.5
RPL36	-16436.5
RPL18A	-16395.5
RPLP0	-16315.5
RPL17	-16078.5
RPL14	-15979.5
RPL27	-15955.5
SPCS3	-15754.5
RPL37A	-15628.5
SEC61B	-15604.5
RPS28	-15367.5
RPS25	-15248.5
RPS13	-15062.5
RPS29	-14798.5
SPCS2	-14772.5
SEC61G	-14684.5
SEC11A	-14563.5
SRPRB	-14482.5
SRP54	-14308.5
RPS18	-14256.5
RPS23	-14233.5
RPS5	-13741.5
RPL30	-13428.5
RPL21	-13384.0
SRP19	-13332.5
RPN2	-13329.5
RPL32	-13137.5
RPS27A	-13086.5
RPL37	-13044.5
RPL22	-13022.5
RPL29	-12825.5
RPS27	-12488.5
RPL31	-12397.5
RPL8	-11935.5
RPSA	-11874.5
DDOST	-11617.5
RPL13A	-11540.0
RPS11	-11531.5
RPS15A	-11448.5
RPS3	-11188.5
RPLP1	-10916.5
TRAM1	-10770.5
RPL23	-10744.5
RPL6	-10548.5
SEC61A1	-10531.5
RPN1	-10186.5
SSR2	-10015.5
RPL19	-9774.5
RPL5	-9652.5
SEC61A2	-9277.5
RPS14	-9097.5
UBA52	-8709.5
RPS26	-8333.5
RPL35A	-7574.5
RPS12	-7221.5
SSR3	-6995.5
SRP68	-6581.5
RPS20	-6516.5
SEC11C	-6126.5
RPS24	-4512.5
RPS7	-4479.5
RPL7A	-4437.5
SSR1	-4118.5
RPL24	-4018.5
RPS6	-3673.5
RPL9	-3553.5
RPL3L	-3327.5
RPL38	-2842.5
RPS8	-2717.5
RPS19	-2624.5
RPL10L	-1873.5
RPL4	-1829.5
RPS17	0.5
RPS9	1795.5
RPL34	2134.5
RPL3	3441.5

---

Nuclear Events (kinase and transcription factor activation)

Nuclear Events (kinase and transcription factor activation)

	828
set	Nuclear Events (kinase and transcription factor activation)
setSize	60
pANOVA	4.68e-11
s.dist	-0.491
p.adjustANOVA	8.12e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDK5R2	-18801.5
DUSP6	-18774.5
EGR3	-18601.5
ASCL1	-18566.5
PPP2R5D	-18483.5
VGF	-18433.5
EGR1	-18432.5
MAPK7	-18336.5
FOS	-18194.5
PPP2CA	-18127.5
JUNB	-18103.5
ID2	-18084.5
CDK5	-17940.5
PPP2R1A	-17915.5
ID1	-17772.5
F3	-17649.5
JUND	-17563.5
SRF	-17508.5
FOSB	-17264.5
DUSP7	-17247.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDK5R2	-18801.5
DUSP6	-18774.5
EGR3	-18601.5
ASCL1	-18566.5
PPP2R5D	-18483.5
VGF	-18433.5
EGR1	-18432.5
MAPK7	-18336.5
FOS	-18194.5
PPP2CA	-18127.5
JUNB	-18103.5
ID2	-18084.5
CDK5	-17940.5
PPP2R1A	-17915.5
ID1	-17772.5
F3	-17649.5
JUND	-17563.5
SRF	-17508.5
FOSB	-17264.5
DUSP7	-17247.5
DUSP4	-16920.5
NAB2	-16760.5
ID4	-16729.5
REST	-16639.5
FOSL1	-16624.5
EGR4	-16570.5
DNM2	-16114.5
MAPK11	-16049.5
LYL1	-15595.5
MAPK14	-15169.5
VRK3	-13660.5
ID3	-13523.5
ARC	-12641.5
RRAD	-12406.5
RPS6KA5	-12312.5
TF	-12215.5
CDK5R1	-12140.5
ATF2	-11989.5
TRIB1	-11526.5
EGR2	-10690.5
MAPK3	-9406.5
DUSP3	-8451.5
PPP2R1B	-8235.5
MEF2A	-8117.5
EP300	-7235.5
MAPK1	-6252.5
MEF2C	-6014.5
SH3GL3	-5853.5
SGK1	-5727.5
RPS6KA1	-5349.5
NAB1	-5196.5
ATF1	-5191.5
CREB1	-5133.5
MEF2D	-4780.5
TCF12	-4423.5
RPS6KA2	-2812.5
TPH1	1993.5
MAPKAPK2	3005.5
CHD4	4355.5
PPP2CB	4425.5

---

Mitochondrial translation elongation

Mitochondrial translation elongation

	744
set	Mitochondrial translation elongation
setSize	87
pANOVA	2.51e-15
s.dist	-0.49
p.adjustANOVA	7.67e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL41	-18603.5
MRPL55	-18331.5
MRPL17	-18326.5
AURKAIP1	-18287.5
OXA1L	-18053.5
MRPS34	-18040.5
MRPS12	-17987.5
MRPL49	-17926.5
MRPL32	-17921.5
MRPS26	-17733.5
MRPL40	-17713.5
MRPL47	-17449.5
MRPL53	-17302.5
MRPS11	-16872.5
MRPL36	-16731.5
MRPL51	-16690.5
MRPS7	-16544.5
MRPS15	-16439.5
MRPL38	-16317.5
MRPL54	-16228.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL41	-18603.5
MRPL55	-18331.5
MRPL17	-18326.5
AURKAIP1	-18287.5
OXA1L	-18053.5
MRPS34	-18040.5
MRPS12	-17987.5
MRPL49	-17926.5
MRPL32	-17921.5
MRPS26	-17733.5
MRPL40	-17713.5
MRPL47	-17449.5
MRPL53	-17302.5
MRPS11	-16872.5
MRPL36	-16731.5
MRPL51	-16690.5
MRPS7	-16544.5
MRPS15	-16439.5
MRPL38	-16317.5
MRPL54	-16228.5
MRPS30	-16203.5
MRPS2	-15951.5
MRPL18	-15855.5
MRPS9	-15764.5
MRPL13	-15668.5
MRPS16	-15610.5
PTCD3	-15551.5
MRPS24	-15546.5
MRPL12	-15478.5
MRPL37	-15238.5
MRPL46	-15236.5
MRPL30	-15103.5
MRPS18B	-14945.5
MRPS23	-14808.5
MRPL19	-14658.5
MRPL21	-14617.5
GFM1	-14599.5
MRPL57	-14561.5
MRPL42	-14404.5
MRPL39	-14218.5
MRPL44	-14181.5
MRPL24	-14111.5
MRPS5	-13949.5
CHCHD1	-13909.5
MRPS25	-13529.5
MRPS17	-13398.5
ERAL1	-13033.5
MRPL10	-12913.5
MRPL43	-12898.5
MRPS10	-12828.5
MRPL52	-12345.5
MRPS31	-12217.5
MRPL3	-11826.5
MRPS27	-11472.5
MRPS18A	-11164.5
MRPS28	-11160.5
MRPL50	-11107.5
TUFM	-11087.5
MRPL14	-10783.5
MRPL28	-10682.5
MRPL15	-10341.5
MRPS36	-10151.5
MRPL27	-10068.5
MRPL48	-9815.5
MRPL20	-9542.5
MRPL35	-9444.5
MRPL34	-9390.5
MRPL23	-8484.5
MRPL4	-7942.5
MRPL22	-7754.5
MRPL11	-7211.5
MRPL9	-6922.5
MRPS18C	-6313.5
DAP3	-6191.5
GADD45GIP1	-6005.5
MRPS22	-5610.5
MRPS35	-5500.5
MRPL33	-5275.5
MRPS33	-4697.5
MRPS6	-4246.5
MRPS21	-4210.5
MRPL1	-3123.5
MRPS14	-3030.5
MRPL2	-2181.5
MRPL16	-1482.5
TSFM	2508.5
MRPL45	3635.5

---

Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes

	227
set	Condensation of Prometaphase Chromosomes
setSize	11
pANOVA	0.00496
s.dist	-0.489
p.adjustANOVA	0.0139

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSNK2B	-18852.5
SMC4	-16719.5
CDK1	-16357.5
NCAPG	-15978.5
NCAPH	-15417.5
CCNB2	-14866.5
SMC2	-14168.5
CCNB1	-6940.5
CSNK2A2	-5394.5
CSNK2A1	-4776.5
NCAPD2	-4698.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSNK2B	-18852.5
SMC4	-16719.5
CDK1	-16357.5
NCAPG	-15978.5
NCAPH	-15417.5
CCNB2	-14866.5
SMC2	-14168.5
CCNB1	-6940.5
CSNK2A2	-5394.5
CSNK2A1	-4776.5
NCAPD2	-4698.5

---

Viral mRNA Translation

Viral mRNA Translation

	1478
set	Viral mRNA Translation
setSize	84
pANOVA	9.63e-15
s.dist	-0.488
p.adjustANOVA	2.78e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	-18753.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
RPL10A	-17335.5
RPL41	-17298.5
RPS15	-16904.5
RPL12	-16833.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	-18753.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
RPL10A	-17335.5
RPL41	-17298.5
RPS15	-16904.5
RPL12	-16833.5
RPL39L	-16785.5
RPL36AL	-16745.5
RPL7	-16696.5
RPL26	-16612.5
RPS3A	-16535.5
RPL11	-16448.5
RPL36	-16436.5
RPL18A	-16395.5
RPLP0	-16315.5
RPL17	-16078.5
RPL14	-15979.5
RPL27	-15955.5
RPL37A	-15628.5
DNAJC3	-15598.5
RPS28	-15367.5
GRSF1	-15313.5
RPS25	-15248.5
RPS13	-15062.5
RPS29	-14798.5
RPS18	-14256.5
RPS23	-14233.5
RPS5	-13741.5
RPL30	-13428.5
RPL21	-13384.0
RPL32	-13137.5
RPS27A	-13086.5
RPL37	-13044.5
RPL22	-13022.5
RPL29	-12825.5
RPS27	-12488.5
RPL31	-12397.5
RPL8	-11935.5
RPSA	-11874.5
RPL13A	-11540.0
RPS11	-11531.5
RPS15A	-11448.5
RPS3	-11188.5
RPLP1	-10916.5
RPL23	-10744.5
RPL6	-10548.5
RPL19	-9774.5
RPL5	-9652.5
RPS14	-9097.5
UBA52	-8709.5
RPS26	-8333.5
RPL35A	-7574.5
RPS12	-7221.5
RPS20	-6516.5
RPS24	-4512.5
RPS7	-4479.5
RPL7A	-4437.5
RPL24	-4018.5
RPS6	-3673.5
RPL9	-3553.5
RPL3L	-3327.5
RPL38	-2842.5
RPS8	-2717.5
RPS19	-2624.5
RPL10L	-1873.5
RPL4	-1829.5
RPS17	0.5
RPS9	1795.5
RPL34	2134.5
RPL3	3441.5

---

Activation of the AP-1 family of transcription factors

Activation of the AP-1 family of transcription factors

	53
set	Activation of the AP-1 family of transcription factors
setSize	10
pANOVA	0.00751
s.dist	-0.488
p.adjustANOVA	0.0197

Top enriched genes

Top 20 genes

GeneID	Gene Rank
JUN	-18340.5
FOS	-18194.5
MAPK9	-17253.5
MAPK11	-16049.5
MAPK14	-15169.5
ATF2	-11989.5
MAPK8	-11853.5
MAPK3	-9406.5
MAPK1	-6252.5
MAPK10	2664.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
JUN	-18340.5
FOS	-18194.5
MAPK9	-17253.5
MAPK11	-16049.5
MAPK14	-15169.5
ATF2	-11989.5
MAPK8	-11853.5
MAPK3	-9406.5
MAPK1	-6252.5
MAPK10	2664.5

---

Signaling by FGFR2 IIIa TM

Signaling by FGFR2 IIIa TM

	1240
set	Signaling by FGFR2 IIIa TM
setSize	19
pANOVA	0.000251
s.dist	-0.485
p.adjustANOVA	0.00101

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-18515.5
POLR2D	-18309.5
POLR2I	-17740.5
POLR2L	-17726.5
GTF2F1	-17225.5
POLR2A	-15976.5
POLR2B	-15522.5
POLR2F	-15151.5
POLR2C	-14409.5
POLR2E	-13593.5
POLR2K	-11800.5
POLR2G	-11643.5
POLR2H	-10479.5
NCBP2	-7657.5
POLR2J	-7501.5
FGF2	-5950.5
GTF2F2	-5589.5
FGFR2	-3884.5
FGF1	-2034.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-18515.5
POLR2D	-18309.5
POLR2I	-17740.5
POLR2L	-17726.5
GTF2F1	-17225.5
POLR2A	-15976.5
POLR2B	-15522.5
POLR2F	-15151.5
POLR2C	-14409.5
POLR2E	-13593.5
POLR2K	-11800.5
POLR2G	-11643.5
POLR2H	-10479.5
NCBP2	-7657.5
POLR2J	-7501.5
FGF2	-5950.5
GTF2F2	-5589.5
FGFR2	-3884.5
FGF1	-2034.5

---

Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors

	399
set	Expression and translocation of olfactory receptors
setSize	365
pANOVA	2.25e-57
s.dist	0.485
p.adjustANOVA	1.13e-54

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR4M2	7194.5
OR7C1	7121.5
OR2Z1	7090.5
OR5H2	7063.5
OR2AG1	7052.5
OR11H4	6994.5
OR12D2	6966.5
OR2AG2	6962.5
OR9Q1	6957.5
OR7E24	6928.5
OR1D2	6918.5
OR8B8	6822.5
OR52I2	6811.5
OR5P2	6800.5
OR6V1	6781.5
OR2M5	6772.5
OR10Q1	6757.5
OR7G1	6727.5
OR4E2	6691.5
OR5A2	6620.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR4M2	7194.5
OR7C1	7121.5
OR2Z1	7090.5
OR5H2	7063.5
OR2AG1	7052.5
OR11H4	6994.5
OR12D2	6966.5
OR2AG2	6962.5
OR9Q1	6957.5
OR7E24	6928.5
OR1D2	6918.5
OR8B8	6822.5
OR52I2	6811.5
OR5P2	6800.5
OR6V1	6781.5
OR2M5	6772.5
OR10Q1	6757.5
OR7G1	6727.5
OR4E2	6691.5
OR5A2	6620.5
OR7D2	6595.5
OR2D2	6562.5
OR7A17	6559.5
OR9A2	6476.5
OR51A7	6469.5
OR4A15	6448.5
OR2L8	6442.5
OR1J4	6405.5
OR2A5	6400.5
OR8H3	6380.5
OR4N2	6305.5
OR8H1	6297.5
OR6B2	6273.5
OR8H2	6232.5
OR13J1	6197.5
OR4C16	6152.5
OR7C2	6122.5
OR7A10	6119.5
OR4C46	6026.5
OR9Q2	6020.5
OR2J3	6000.5
OR10G3	5986.5
OR13C9	5976.5
OR5T2	5974.5
OR6K3	5943.5
OR9I1	5937.5
OR4A47	5933.5
OR2A2	5924.5
OR56A4	5853.5
OR8K1	5849.5
OR10G8	5839.5
OR52A5	5795.5
OR8G2	5794.5
OR8U8	5776.5
OR2AE1	5742.5
OR4N5	5728.5
OR13C8	5722.5
OR2L3	5619.5
OR10H5	5594.5
OR2T5	5581.5
OR1E1	5541.5
OR5AS1	5529.5
OR4K13	5523.5
OR2B2	5513.5
OR2M2	5501.5
OR10H3	5450.5
OR52L1	5383.5
OR5M3	5367.5
OR52E6	5338.5
OR11H6	5335.5
OR6K6	5322.5
OR6C1	5275.5
OR5A1	5262.5
OR2B3	5254.5
OR5M8	5211.5
OR6C75	5195.5
OR10G7	5188.5
OR5M9	5179.5
OR11A1	5157.5
RTP1	5110.5
OR2T33	5099.5
OR5B2	5079.5
OR51T1	5014.5
OR4D5	4991.5
OR2D3	4887.5
OR1B1	4876.5
OR2C1	4842.5
OR5C1	4751.5
OR2V2	4742.5
OR51G1	4639.5
OR4L1	4611.5
OR51B2	4579.5
OR10J1	4516.5
OR8K3	4446.5
OR6C68	4424.5
OR52N1	4354.5
OR52A1	4304.5
OR7D4	4288.5
OR52E8	4245.5
OR8A1	4178.5
OR2J2	4165.5
OR4C6	4086.5
OR5V1	4085.5
OR10AD1	4072.5
OR5I1	4031.5
OR10H1	4028.5
OR14J1	3921.5
OR6N1	3901.5
OR5B3	3725.5
OR4K1	3706.5
OR5L1	3699.5
OR5K3	3689.5
OR6A2	3651.5
OR10G2	3631.5
OR2L2	3625.5
OR13G1	3588.5
OR1N1	3542.5
OR8B4	3527.5
OR10H4	3503.5
OR2V1	3459.5
OR6C65	3428.5
OR7G2	3381.5
OR13C3	3342.5
OR5L2	3305.5
OR10A6	3291.5
OR2L13	3290.5
RTP2	3266.5
OR2Y1	3251.5
OR2K2	3244.5
OR10G9	3207.5
OR1S2	3136.5
OR1A1	3082.5
OR2T29	3052.5
OR1F1	2908.5
OR51F2	2886.5
OR52B6	2788.5
OR10C1	2771.5
OR6F1	2743.5
OR2AK2	2552.5
OR10X1	2546.5
OR1I1	2507.5
OR6N2	2450.5
OR10K1	2331.5
OR6T1	2258.5
OR6X1	2250.5
OR5AP2	2203.5
OR2C3	2059.5
OR6B1	2036.5
OR10V1	2011.5
OR9K2	1986.5
OR1G1	1984.5
OR2F1	1962.5
OR1L3	1940.5
OR51S1	1738.5
OR11G2	1736.5
OR5AU1	1659.5
OR12D3	1624.5
OR56A1	1526.5
OR2T4	1180.5
OR7A5	1159.5
OR5T1	0.5
OR5H1	0.5
OR2S2	0.5
OR2A25	0.5
OR10Z1	0.5
OR8I2	0.5
OR2G6	0.5
OR2A14	0.5
OR9G4	0.5
OR52K2	0.5
OR4S1	0.5
OR2A12	0.5
OR2T2	0.5
OR2AP1	0.5
OR4A16	0.5
OR10K2	0.5
OR4A5	0.5
OR10J5	0.5
OR5D13	0.5
OR51D1	0.5
OR4B1	0.5
OR4N4	0.5
OR51G2	0.5
OR10AG1	0.5
OR2M7	0.5
OR52J3	0.5
OR4K15	0.5
OR2A4	0.5
OR6K2	0.5
OR6B3	0.5
OR5H14	0.5
OR56B4	0.5
OR5B17	0.5
OR6S1	0.5
OR2T35	0.5
OR5AR1	0.5
OR5M11	0.5
OR52N4	0.5
OR7G3	0.5
OR5K1	0.5
OR6C4	0.5
OR4D2	0.5
OR5K4	0.5
OR9A4	0.5
OR5D16	0.5
OR2B11	0.5
OR8J1	0.5
OR4F4	0.5
OR2B6	0.5
OR2G3	0.5
OR51F1	0.5
OR6Y1	0.5
OR5AN1	0.5
OR5M10	0.5
OR1L1	0.5
OR4C12	0.5
OR5P3	0.5
OR6C6	0.5
OR8U1	0.5
OR6M1	0.5
OR5T3	0.5
OR6Q1	0.5
OR14I1	0.5
OR2G2	0.5
OR1D5	0.5
OR1D4	0.5
OR13C4	0.5
OR5B21	0.5
OR51V1	0.5
OR13C2	0.5
OR10A2	0.5
OR13D1	0.5
OR5J2	0.5
OR6C74	0.5
OR52E2	0.5
OR4K14	0.5
OR4C45	0.5
OR4X2	0.5
OR1J1	0.5
OR52N2	0.5
OR4M1	0.5
OR56B1	0.5
OR5AK2	0.5
OR4K17	0.5
OR6C3	0.5
OR1Q1	0.5
OR6C70	0.5
OR6C2	0.5
OR4Q3	0.5
OR4C15	0.5
OR10R2	0.5
OR10T2	0.5
OR2A1	0.5
OR52D1	0.5
OR8B3	0.5
OR2F2	0.5
OR1L4	0.5
OR52N5	0.5
OR52E4	0.5
OR4C13	0.5
OR1L6	0.5
OR1N2	0.5
OR2L5	0.5
OR4D1	-1377.5
OR56A3	-1595.5
OR4F5	-1640.5
OR51E2	-1821.5
OR1E2	-1840.5
OR13A1	-1907.5
OR9G1	-1960.0
OR9G9	-1960.0
OR2M3	-2027.5
OR5AC2	-2115.5
OR5D18	-2224.5
OR4F15	-2305.5
OR4F6	-2326.5
OR2T12	-2391.5
OR2W1	-2470.5
OR1C1	-2534.5
OR10H2	-2626.5
OR5H6	-2635.5
OR4D9	-2636.5
OR2H1	-2645.5
OR8B2	-2686.5
OR1K1	-2832.5
OR8D1	-2878.5
OR52K1	-2930.5
OR1S1	-2940.5
OR10A4	-2960.5
OR51I1	-2975.5
OR8J3	-3116.5
OR4D10	-3133.5
OR1A2	-3173.5
OR8D2	-3226.5
OR5D14	-3510.5
OR8K5	-3557.5
OR1J2	-3572.5
OR6P1	-3579.5
OR10J3	-3889.5
OR8G1	-3907.5
OR2T8	-4125.5
OR1L8	-4175.5
OR2T34	-4278.5
OR14C36	-4281.5
OR3A3	-4393.5
OR4D11	-4401.5
OR10G4	-4522.5
OR10A3	-4600.5
OR2T11	-4758.5
OR8B12	-4827.5
OR6C76	-5021.5
OR52H1	-5145.5
OR4K5	-5292.5
OR5W2	-5347.5
OR51L1	-5351.5
OR1M1	-5382.5
OR2W3	-5508.5
OR8S1	-5701.5
OR2T1	-5729.5
OR8D4	-5819.5
OR4X1	-5875.5
OR51B4	-6018.5
OR10A5	-6066.5
OR2W5	-6201.5
OR51B6	-6216.5
OR4D6	-6329.5
OR2T3	-6386.5
OR3A1	-6391.5
OR2T6	-6535.5
OR11L1	-6591.5
EBF1	-6636.5
OR10P1	-6780.5
OR2T27	-6970.5
OR56A5	-7005.5
OR10W1	-7019.5
OR5F1	-7293.5
OR5B12	-7356.5
OR3A2	-7445.5
OR51A2	-7471.5
OR8G5	-7780.5
OR14A16	-7878.5
OR10S1	-8147.5
OR52R1	-8408.5
OR2H2	-8458.5
OR4K2	-8511.5
OR51E1	-8538.5
OR5K2	-8625.5
OR5R1	-8805.5
OR10A7	-9200.5
OR52B2	-9386.5
OR13F1	-9402.5
OR2AT4	-9727.5
OR51Q1	-10195.5
OR2M4	-10200.5
OR52I1	-10230.5
OR51B5	-10430.5
OR52W1	-10485.5
OR51M1	-10934.5
OR4C3	-11001.5
OR52M1	-11632.5
OR5M1	-11648.5
LHX2	-13379.5
OR51I2	-15582.5
REEP1	-15890.5
LDB1	-18364.5

---

Transcriptional regulation of testis differentiation

Transcriptional regulation of testis differentiation

	1426
set	Transcriptional regulation of testis differentiation
setSize	12
pANOVA	0.00369
s.dist	-0.484
p.adjustANOVA	0.0109

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FOXL2	-18868.5
WT1	-18784.5
SOX9	-18243.5
GATA4	-17870.5
DHH	-17539.5
FGF9	-14676.5
DMRT1	-14622.5
AMH	-10654.5
PTGDS	-5830.5
WNT4	-5665.5
NR5A1	-1555.5
ZFPM2	-1244.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FOXL2	-18868.5
WT1	-18784.5
SOX9	-18243.5
GATA4	-17870.5
DHH	-17539.5
FGF9	-14676.5
DMRT1	-14622.5
AMH	-10654.5
PTGDS	-5830.5
WNT4	-5665.5
NR5A1	-1555.5
ZFPM2	-1244.5

---

RAF-independent MAPK1/3 activation

RAF-independent MAPK1/3 activation

	984
set	RAF-independent MAPK1/3 activation
setSize	22
pANOVA	8.74e-05
s.dist	-0.483
p.adjustANOVA	0.000398

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DUSP6	-18774.5
DUSP1	-18415.5
DUSP2	-17882.5
DUSP8	-17534.5
DUSP7	-17247.5
DUSP4	-16920.5
JAK1	-16666.5
CDK1	-16357.5
PEA15	-13521.5
IL6ST	-13476.5
DUSP16	-13389.5
IL6R	-13320.5
DUSP5	-12425.5
PTPN11	-11195.5
MAP2K2	-10803.5
MAPK3	-9406.5
DUSP10	-9229.5
TYK2	-7976.5
MAPK1	-6252.5
MAP2K1	-5296.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DUSP6	-18774.5
DUSP1	-18415.5
DUSP2	-17882.5
DUSP8	-17534.5
DUSP7	-17247.5
DUSP4	-16920.5
JAK1	-16666.5
CDK1	-16357.5
PEA15	-13521.5
IL6ST	-13476.5
DUSP16	-13389.5
IL6R	-13320.5
DUSP5	-12425.5
PTPN11	-11195.5
MAP2K2	-10803.5
MAPK3	-9406.5
DUSP10	-9229.5
TYK2	-7976.5
MAPK1	-6252.5
MAP2K1	-5296.5
JAK2	-4543.5
IL6	4101.5

---

Translation

Translation

	1429
set	Translation
setSize	263
pANOVA	1.76e-41
s.dist	-0.482
p.adjustANOVA	2.99e-39

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SPCS1	-18871.5
TRMT112	-18856.5
RPS27L	-18753.5
EIF2B4	-18743.5
RPL18	-18627.5
RPL15	-18621.5
MRPL41	-18603.5
GFM2	-18507.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
SRP9	-18351.5
MRPL55	-18331.5
MRPL17	-18326.5
SRP14	-18322.5
MTIF3	-18304.5
AURKAIP1	-18287.5
EIF3J	-18235.5
RPL23A	-18167.5
RPS21	-18100.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SPCS1	-18871.5
TRMT112	-18856.5
RPS27L	-18753.5
EIF2B4	-18743.5
RPL18	-18627.5
RPL15	-18621.5
MRPL41	-18603.5
GFM2	-18507.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
SRP9	-18351.5
MRPL55	-18331.5
MRPL17	-18326.5
SRP14	-18322.5
MTIF3	-18304.5
AURKAIP1	-18287.5
EIF3J	-18235.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
OXA1L	-18053.5
EIF5	-18047.5
MRPS34	-18040.5
EIF5B	-18039.5
RPS2	-17999.5
MRPS12	-17987.5
MRPL49	-17926.5
MRPL32	-17921.5
RPLP2	-17913.5
MTRF1L	-17869.5
MRPS26	-17733.5
MRPL40	-17713.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
MRPL47	-17449.5
RPS16	-17418.5
EIF3K	-17396.5
RPL10A	-17335.5
MRPL53	-17302.5
EEF1A2	-17299.5
RPL41	-17298.5
EEF1B2	-17296.5
EEF1D	-17282.5
EIF4EBP1	-17263.5
SRP72	-17172.5
DARS2	-17074.5
MTFMT	-17009.5
RPS15	-16904.5
MRPS11	-16872.5
RPL12	-16833.5
HARS2	-16821.5
RPL39L	-16785.5
RPL36AL	-16745.5
SARS2	-16738.5
MRPL36	-16731.5
RPL7	-16696.5
MRPL51	-16690.5
RPL26	-16612.5
MRPS7	-16544.5
RPS3A	-16535.5
RPL11	-16448.5
MRPS15	-16439.5
RPL36	-16436.5
RPL18A	-16395.5
MRPL38	-16317.5
RPLP0	-16315.5
MRPL54	-16228.5
MRPS30	-16203.5
EIF2B1	-16161.5
VARS2	-16158.5
YARS2	-16112.5
RPL17	-16078.5
EEF1A1	-16051.5
EEF1G	-16000.5
RPL14	-15979.5
RPL27	-15955.5
MRPS2	-15951.5
MRPL18	-15855.5
MRPS9	-15764.5
SPCS3	-15754.5
MRPL13	-15668.5
RPL37A	-15628.5
MRPS16	-15610.5
SEC61B	-15604.5
PTCD3	-15551.5
MRPS24	-15546.5
MRPL12	-15478.5
MARS2	-15460.5
RPS28	-15367.5
EIF2B2	-15357.5
RPS25	-15248.5
MRPL37	-15238.5
MRPL46	-15236.5
EIF2S1	-15187.5
MRPL30	-15103.5
RPS13	-15062.5
MRPS18B	-14945.5
MRPS23	-14808.5
RPS29	-14798.5
SPCS2	-14772.5
SEC61G	-14684.5
MRPL19	-14658.5
MRPL21	-14617.5
GFM1	-14599.5
EIF3I	-14578.5
SEC11A	-14563.5
MRPL57	-14561.5
EIF4H	-14510.5
SRPRB	-14482.5
MRPL42	-14404.5
SRP54	-14308.5
RPS18	-14256.5
RPS23	-14233.5
MRPL39	-14218.5
MRPL44	-14181.5
EIF3D	-14154.5
MRPL24	-14111.5
MRPS5	-13949.5
CHCHD1	-13909.5
RPS5	-13741.5
AIMP1	-13645.5
EIF2B5	-13568.5
FARSB	-13549.5
MRPS25	-13529.5
RPL30	-13428.5
MRPS17	-13398.5
RPL21	-13384.0
EIF3M	-13360.5
SRP19	-13332.5
RPN2	-13329.5
RPL32	-13137.5
RPS27A	-13086.5
RPL37	-13044.5
ERAL1	-13033.5
RPL22	-13022.5
APEH	-12946.5
MRPL10	-12913.5
MRPL43	-12898.5
MRPS10	-12828.5
RPL29	-12825.5
EIF4A2	-12714.5
MRRF	-12623.5
RPS27	-12488.5
RPL31	-12397.5
EIF3L	-12370.5
MRPL52	-12345.5
MRPS31	-12217.5
RARS2	-12031.5
RPL8	-11935.5
RPSA	-11874.5
MRPL3	-11826.5
EIF3F	-11823.5
EIF2S2	-11772.5
DDOST	-11617.5
RPL13A	-11540.0
RPS11	-11531.5
MRPS27	-11472.5
RPS15A	-11448.5
WARS2	-11344.5
IARS2	-11305.5
ETF1	-11258.5
RPS3	-11188.5
MRPS18A	-11164.5
MRPS28	-11160.5
MRPL50	-11107.5
TUFM	-11087.5
PPA2	-11071.5
RPLP1	-10916.5
EIF4E	-10885.5
MRPL14	-10783.5
TRAM1	-10770.5
RPL23	-10744.5
MRPL28	-10682.5
EIF3G	-10586.5
RPL6	-10548.5
SEC61A1	-10531.5
PPA1	-10427.5
MRPL15	-10341.5
RPN1	-10186.5
MRPS36	-10151.5
EIF4B	-10147.5
MRPL27	-10068.5
SSR2	-10015.5
MRPL48	-9815.5
RPL19	-9774.5
RPL5	-9652.5
MRPL20	-9542.5
MTIF2	-9488.5
AARS2	-9472.5
MRPL35	-9444.5
MRPL34	-9390.5
EIF3A	-9353.5
SEC61A2	-9277.5
AIMP2	-9235.5
RPS14	-9097.5
N6AMT1	-8974.5
LARS2	-8955.5
UBA52	-8709.5
MRPL23	-8484.5
RPS26	-8333.5
PABPC1	-8001.5
MRPL4	-7942.5
MRPL22	-7754.5
RPL35A	-7574.5
PARS2	-7547.5
EIF3C	-7427.5
RPS12	-7221.5
MRPL11	-7211.5
EIF3B	-7198.5
SSR3	-6995.5
MRPL9	-6922.5
EEF2	-6814.5
SRP68	-6581.5
RPS20	-6516.5
MRPS18C	-6313.5
DAP3	-6191.5
SEC11C	-6126.5
GADD45GIP1	-6005.5
EARS2	-5911.5
TARS2	-5872.5
MRPS22	-5610.5
MRPS35	-5500.5
MRPL33	-5275.5
EIF2B3	-5013.5
MRPS33	-4697.5
RPS24	-4512.5
RPS7	-4479.5
RPL7A	-4437.5
FARSA	-4414.5
EEF1E1	-4286.5
MRPS6	-4246.5
MRPS21	-4210.5
SSR1	-4118.5
EIF4G1	-4098.5
RPL24	-4018.5
RPS6	-3673.5
RPL9	-3553.5
RPL3L	-3327.5
EIF4A1	-3299.5
MRPL1	-3123.5
MRPS14	-3030.5
RPL38	-2842.5
RPS8	-2717.5
RPS19	-2624.5
EIF3H	-2468.5
GSPT1	-2209.5
MRPL2	-2181.5
RPL10L	-1873.5
RPL4	-1829.5
FARS2	-1696.5
MRPL16	-1482.5
CARS2	-1238.5
RPS17	0.5
RPS9	1795.5
RPL34	2134.5
TSFM	2508.5
EIF3E	2645.5
NARS2	3190.5
RPL3	3441.5
MRPL45	3635.5

---

SCF(Skp2)-mediated degradation of p27/p21

SCF(Skp2)-mediated degradation of p27/p21

	1157
set	SCF(Skp2)-mediated degradation of p27/p21
setSize	58
pANOVA	2.26e-10
s.dist	-0.481
p.adjustANOVA	3.67e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1B	-18818.5
PSMB8	-18363.5
CCNA1	-18253.5
PSMB9	-18251.5
PSMC3	-18176.5
PSMA7	-18147.5
PSME1	-18006.5
CCNA2	-17945.5
PSMB3	-17758.5
PSME2	-17594.5
CCNE1	-17507.5
PSMB6	-17477.5
PSMB5	-17167.5
PSMD13	-17137.5
CKS1B	-17072.5
PSME3	-16685.5
PSMC5	-16582.5
CCND1	-16516.5
PSMA5	-15925.5
PSMA2	-15880.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1B	-18818.5
PSMB8	-18363.5
CCNA1	-18253.5
PSMB9	-18251.5
PSMC3	-18176.5
PSMA7	-18147.5
PSME1	-18006.5
CCNA2	-17945.5
PSMB3	-17758.5
PSME2	-17594.5
CCNE1	-17507.5
PSMB6	-17477.5
PSMB5	-17167.5
PSMD13	-17137.5
CKS1B	-17072.5
PSME3	-16685.5
PSMC5	-16582.5
CCND1	-16516.5
PSMA5	-15925.5
PSMA2	-15880.5
PSMB4	-15798.5
PSMB1	-15702.5
PSMD1	-15587.5
CDK4	-15554.5
SKP1	-15373.5
PSMA3	-15114.5
PSMD3	-15088.5
PSMC1	-15000.5
PSMD11	-14567.5
PSMA6	-14547.5
PSMA4	-14088.5
PSMB10	-13456.5
PSMD4	-13353.5
RPS27A	-13086.5
PSMD8	-12316.5
CDKN1A	-12290.5
PSMD6	-12150.5
PSMD14	-12131.5
PSMD7	-11860.5
PSMB2	-11764.5
CCNE2	-11056.5
PSMD2	-10914.5
UBB	-9131.5
UBA52	-8709.5
CDK2	-8162.5
SKP2	-8016.5
PSMD9	-7958.5
PSMC4	-7233.5
PSMD12	-6447.5
UBC	-6069.5
PSMC6	-4427.5
PSMD5	-2452.5
PSMC2	-1487.5
PSMA1	2571.5
PTK6	2696.5
PSMF1	3885.5
CUL1	4360.5
PSMB7	5882.5

---

Peptide chain elongation

Peptide chain elongation

	896
set	Peptide chain elongation
setSize	84
pANOVA	2.4e-14
s.dist	-0.481
p.adjustANOVA	6.54e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	-18753.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
RPL10A	-17335.5
RPL41	-17298.5
RPS15	-16904.5
RPL12	-16833.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	-18753.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
RPL10A	-17335.5
RPL41	-17298.5
RPS15	-16904.5
RPL12	-16833.5
RPL39L	-16785.5
RPL36AL	-16745.5
RPL7	-16696.5
RPL26	-16612.5
RPS3A	-16535.5
RPL11	-16448.5
RPL36	-16436.5
RPL18A	-16395.5
RPLP0	-16315.5
RPL17	-16078.5
EEF1A1	-16051.5
RPL14	-15979.5
RPL27	-15955.5
RPL37A	-15628.5
RPS28	-15367.5
RPS25	-15248.5
RPS13	-15062.5
RPS29	-14798.5
RPS18	-14256.5
RPS23	-14233.5
RPS5	-13741.5
RPL30	-13428.5
RPL21	-13384.0
RPL32	-13137.5
RPS27A	-13086.5
RPL37	-13044.5
RPL22	-13022.5
RPL29	-12825.5
RPS27	-12488.5
RPL31	-12397.5
RPL8	-11935.5
RPSA	-11874.5
RPL13A	-11540.0
RPS11	-11531.5
RPS15A	-11448.5
RPS3	-11188.5
RPLP1	-10916.5
RPL23	-10744.5
RPL6	-10548.5
RPL19	-9774.5
RPL5	-9652.5
RPS14	-9097.5
UBA52	-8709.5
RPS26	-8333.5
RPL35A	-7574.5
RPS12	-7221.5
EEF2	-6814.5
RPS20	-6516.5
RPS24	-4512.5
RPS7	-4479.5
RPL7A	-4437.5
RPL24	-4018.5
RPS6	-3673.5
RPL9	-3553.5
RPL3L	-3327.5
RPL38	-2842.5
RPS8	-2717.5
RPS19	-2624.5
RPL10L	-1873.5
RPL4	-1829.5
RPS17	0.5
RPS9	1795.5
RPL34	2134.5
RPL3	3441.5

---

Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade

	119
set	Beta-catenin phosphorylation cascade
setSize	16
pANOVA	0.000893
s.dist	-0.479
p.adjustANOVA	0.00312

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FRAT1	-18642.5
PPP2R5D	-18483.5
PPP2CA	-18127.5
FRAT2	-18052.5
PPP2R1A	-17915.5
CSNK1A1	-17111.5
PPP2R5B	-16909.5
APC	-15124.5
CTNNB1	-13702.5
PPP2R5E	-11201.5
PPP2R1B	-8235.5
PPP2R5C	-7864.5
PPP2R5A	-6824.5
AXIN1	-6153.5
GSK3B	-3224.5
PPP2CB	4425.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FRAT1	-18642.5
PPP2R5D	-18483.5
PPP2CA	-18127.5
FRAT2	-18052.5
PPP2R1A	-17915.5
CSNK1A1	-17111.5
PPP2R5B	-16909.5
APC	-15124.5
CTNNB1	-13702.5
PPP2R5E	-11201.5
PPP2R1B	-8235.5
PPP2R5C	-7864.5
PPP2R5A	-6824.5
AXIN1	-6153.5
GSK3B	-3224.5
PPP2CB	4425.5

---

mRNA Capping

mRNA Capping

	1502
set	mRNA Capping
setSize	28
pANOVA	1.16e-05
s.dist	-0.478
p.adjustANOVA	6.33e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-18515.5
POLR2D	-18309.5
POLR2I	-17740.5
POLR2L	-17726.5
RNMT	-17716.5
GTF2F1	-17225.5
SUPT5H	-17160.5
CCNH	-16122.5
POLR2A	-15976.5
GTF2H1	-15658.5
POLR2B	-15522.5
GTF2H5	-15491.5
GTF2H3	-15207.5
POLR2F	-15151.5
POLR2C	-14409.5
POLR2E	-13593.5
CDK7	-12405.5
GTF2H4	-11975.5
POLR2K	-11800.5
POLR2G	-11643.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-18515.5
POLR2D	-18309.5
POLR2I	-17740.5
POLR2L	-17726.5
RNMT	-17716.5
GTF2F1	-17225.5
SUPT5H	-17160.5
CCNH	-16122.5
POLR2A	-15976.5
GTF2H1	-15658.5
POLR2B	-15522.5
GTF2H5	-15491.5
GTF2H3	-15207.5
POLR2F	-15151.5
POLR2C	-14409.5
POLR2E	-13593.5
CDK7	-12405.5
GTF2H4	-11975.5
POLR2K	-11800.5
POLR2G	-11643.5
POLR2H	-10479.5
ERCC2	-8987.5
NCBP2	-7657.5
POLR2J	-7501.5
GTF2F2	-5589.5
RNGTT	2619.5
ERCC3	4351.5
MNAT1	5060.5

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	397
set	Eukaryotic Translation Termination
setSize	87
pANOVA	1.43e-14
s.dist	-0.477
p.adjustANOVA	4.04e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRMT112	-18856.5
RPS27L	-18753.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
RPL10A	-17335.5
RPL41	-17298.5
RPS15	-16904.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRMT112	-18856.5
RPS27L	-18753.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
RPL10A	-17335.5
RPL41	-17298.5
RPS15	-16904.5
RPL12	-16833.5
RPL39L	-16785.5
RPL36AL	-16745.5
RPL7	-16696.5
RPL26	-16612.5
RPS3A	-16535.5
RPL11	-16448.5
RPL36	-16436.5
RPL18A	-16395.5
RPLP0	-16315.5
RPL17	-16078.5
RPL14	-15979.5
RPL27	-15955.5
RPL37A	-15628.5
RPS28	-15367.5
RPS25	-15248.5
RPS13	-15062.5
RPS29	-14798.5
RPS18	-14256.5
RPS23	-14233.5
RPS5	-13741.5
RPL30	-13428.5
RPL21	-13384.0
RPL32	-13137.5
RPS27A	-13086.5
RPL37	-13044.5
RPL22	-13022.5
APEH	-12946.5
RPL29	-12825.5
RPS27	-12488.5
RPL31	-12397.5
RPL8	-11935.5
RPSA	-11874.5
RPL13A	-11540.0
RPS11	-11531.5
RPS15A	-11448.5
ETF1	-11258.5
RPS3	-11188.5
RPLP1	-10916.5
RPL23	-10744.5
RPL6	-10548.5
RPL19	-9774.5
RPL5	-9652.5
RPS14	-9097.5
N6AMT1	-8974.5
UBA52	-8709.5
RPS26	-8333.5
RPL35A	-7574.5
RPS12	-7221.5
RPS20	-6516.5
RPS24	-4512.5
RPS7	-4479.5
RPL7A	-4437.5
RPL24	-4018.5
RPS6	-3673.5
RPL9	-3553.5
RPL3L	-3327.5
RPL38	-2842.5
RPS8	-2717.5
RPS19	-2624.5
GSPT1	-2209.5
RPL10L	-1873.5
RPL4	-1829.5
RPS17	0.5
RPS9	1795.5
RPL34	2134.5
RPL3	3441.5

---

Endosomal/Vacuolar pathway

Endosomal/Vacuolar pathway

	385
set	Endosomal/Vacuolar pathway
setSize	12
pANOVA	0.00437
s.dist	-0.475
p.adjustANOVA	0.0125

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HLA-H	-17429.5
HLA-C	-16993.5
HLA-E	-16967.5
HLA-A	-16816.5
LNPEP	-15044.5
HLA-B	-14797.5
CTSL	-14632.5
HLA-F	-14313.5
HLA-G	-11597.5
CTSV	-6734.5
B2M	-4986.5
CTSS	6149.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HLA-H	-17429.5
HLA-C	-16993.5
HLA-E	-16967.5
HLA-A	-16816.5
LNPEP	-15044.5
HLA-B	-14797.5
CTSL	-14632.5
HLA-F	-14313.5
HLA-G	-11597.5
CTSV	-6734.5
B2M	-4986.5
CTSS	6149.5

---

Antimicrobial peptides

Antimicrobial peptides

	85
set	Antimicrobial peptides
setSize	82
pANOVA	1.13e-13
s.dist	0.474
p.adjustANOVA	2.65e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RNASE7	7199.5
DEFB118	6945.5
ITLN1	6873.5
DEFB133	6861.5
DEFB123	6856.5
DEFB108B	6821.5
DEFB125	6819.5
DEFA1	6806.0
DEFB105A	6696.0
HTN1	6688.5
LYZ	6672.5
CCR2	6416.5
DEFB132	6349.5
DEFA3	6188.5
ELANE	6132.5
PI3	6101.5
REG3G	5507.5
BPIFB6	5504.5
PGLYRP3	5420.5
DCD	5123.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RNASE7	7199.5
DEFB118	6945.5
ITLN1	6873.5
DEFB133	6861.5
DEFB123	6856.5
DEFB108B	6821.5
DEFB125	6819.5
DEFA1	6806.0
DEFB105A	6696.0
HTN1	6688.5
LYZ	6672.5
CCR2	6416.5
DEFB132	6349.5
DEFA3	6188.5
ELANE	6132.5
PI3	6101.5
REG3G	5507.5
BPIFB6	5504.5
PGLYRP3	5420.5
DCD	5123.5
DEFA4	5007.5
DEFA6	4997.5
DEFB107A	4914.0
TLR1	4839.5
DEFB135	4741.5
CTSG	4603.5
SEMG1	4373.5
DEFB116	4357.5
DEFB129	4356.5
DEFB115	4070.5
CCR6	3909.5
S100A9	3634.5
DEFB1	3589.5
RNASE3	3469.5
RNASE6	3031.5
DEFB121	2660.5
GNLY	2636.5
DEFB131	2597.5
SLC11A1	2041.5
BPIFA2	2040.5
PRTN3	2019.5
PRSS3	1860.5
REG3A	1833.5
BPIFB4	1224.5
S100A8	1198.5
BPIFA1	0.5
DEFB134	0.5
DEFB114	0.5
DEFB106A	0.5
DEFB119	0.5
DEFB113	0.5
DEFB103A	0.5
HTN3	0.5
EPPIN	0.5
DEFB110	0.5
PGLYRP4	-1348.5
LCN2	-1517.5
DEFA5	-1717.5
PGLYRP2	-1750.5
DEFB124	-1793.5
S100A7A	-1978.5
BPIFB1	-2031.5
RNASE8	-2111.5
DEFB127	-2223.5
DEFB104A	-2981.0
BPI	-3539.5
PLA2G2A	-4287.5
DEFB126	-6683.5
ART1	-7253.5
S100A7	-7262.5
CD4	-7620.5
DEFB136	-7790.5
CAMP	-7884.5
BPIFB2	-8878.5
DEFB128	-9437.5
ATOX1	-10078.5
CLU	-11884.5
LEAP2	-12256.5
PGLYRP1	-13210.5
TLR2	-14019.5
LTF	-14961.5
CHGA	-15355.5

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

	165
set	Cap-dependent Translation Initiation
setSize	112
pANOVA	4.5e-18
s.dist	-0.473
p.adjustANOVA	2.09e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	-18753.5
EIF2B4	-18743.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
EIF3J	-18235.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
EIF5	-18047.5
EIF5B	-18039.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	-18753.5
EIF2B4	-18743.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
EIF3J	-18235.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
EIF5	-18047.5
EIF5B	-18039.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
EIF3K	-17396.5
RPL10A	-17335.5
RPL41	-17298.5
EIF4EBP1	-17263.5
RPS15	-16904.5
RPL12	-16833.5
RPL39L	-16785.5
RPL36AL	-16745.5
RPL7	-16696.5
RPL26	-16612.5
RPS3A	-16535.5
RPL11	-16448.5
RPL36	-16436.5
RPL18A	-16395.5
RPLP0	-16315.5
EIF2B1	-16161.5
RPL17	-16078.5
RPL14	-15979.5
RPL27	-15955.5
RPL37A	-15628.5
RPS28	-15367.5
EIF2B2	-15357.5
RPS25	-15248.5
EIF2S1	-15187.5
RPS13	-15062.5
RPS29	-14798.5
EIF3I	-14578.5
EIF4H	-14510.5
RPS18	-14256.5
RPS23	-14233.5
EIF3D	-14154.5
RPS5	-13741.5
EIF2B5	-13568.5
RPL30	-13428.5
RPL21	-13384.0
EIF3M	-13360.5
RPL32	-13137.5
RPS27A	-13086.5
RPL37	-13044.5
RPL22	-13022.5
RPL29	-12825.5
EIF4A2	-12714.5
RPS27	-12488.5
RPL31	-12397.5
EIF3L	-12370.5
RPL8	-11935.5
RPSA	-11874.5
EIF3F	-11823.5
EIF2S2	-11772.5
RPL13A	-11540.0
RPS11	-11531.5
RPS15A	-11448.5
RPS3	-11188.5
RPLP1	-10916.5
EIF4E	-10885.5
RPL23	-10744.5
EIF3G	-10586.5
RPL6	-10548.5
EIF4B	-10147.5
RPL19	-9774.5
RPL5	-9652.5
EIF3A	-9353.5
RPS14	-9097.5
UBA52	-8709.5
RPS26	-8333.5
PABPC1	-8001.5
RPL35A	-7574.5
EIF3C	-7427.5
RPS12	-7221.5
EIF3B	-7198.5
RPS20	-6516.5
EIF2B3	-5013.5
RPS24	-4512.5
RPS7	-4479.5
RPL7A	-4437.5
EIF4G1	-4098.5
RPL24	-4018.5
RPS6	-3673.5
RPL9	-3553.5
RPL3L	-3327.5
EIF4A1	-3299.5
RPL38	-2842.5
RPS8	-2717.5
RPS19	-2624.5
EIF3H	-2468.5
RPL10L	-1873.5
RPL4	-1829.5
RPS17	0.5
RPS9	1795.5
RPL34	2134.5
EIF3E	2645.5
RPL3	3441.5

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

	396
set	Eukaryotic Translation Initiation
setSize	112
pANOVA	4.5e-18
s.dist	-0.473
p.adjustANOVA	2.09e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	-18753.5
EIF2B4	-18743.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
EIF3J	-18235.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
EIF5	-18047.5
EIF5B	-18039.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	-18753.5
EIF2B4	-18743.5
RPL18	-18627.5
RPL15	-18621.5
RPL27A	-18471.5
RPL13	-18454.5
RPL26L1	-18382.5
EIF3J	-18235.5
RPL23A	-18167.5
RPS21	-18100.5
FAU	-18080.5
RPL28	-18064.5
EIF5	-18047.5
EIF5B	-18039.5
RPS2	-17999.5
RPLP2	-17913.5
RPS10	-17573.5
RPL35	-17561.5
RPL22L1	-17481.5
RPS16	-17418.5
EIF3K	-17396.5
RPL10A	-17335.5
RPL41	-17298.5
EIF4EBP1	-17263.5
RPS15	-16904.5
RPL12	-16833.5
RPL39L	-16785.5
RPL36AL	-16745.5
RPL7	-16696.5
RPL26	-16612.5
RPS3A	-16535.5
RPL11	-16448.5
RPL36	-16436.5
RPL18A	-16395.5
RPLP0	-16315.5
EIF2B1	-16161.5
RPL17	-16078.5
RPL14	-15979.5
RPL27	-15955.5
RPL37A	-15628.5
RPS28	-15367.5
EIF2B2	-15357.5
RPS25	-15248.5
EIF2S1	-15187.5
RPS13	-15062.5
RPS29	-14798.5
EIF3I	-14578.5
EIF4H	-14510.5
RPS18	-14256.5
RPS23	-14233.5
EIF3D	-14154.5
RPS5	-13741.5
EIF2B5	-13568.5
RPL30	-13428.5
RPL21	-13384.0
EIF3M	-13360.5
RPL32	-13137.5
RPS27A	-13086.5
RPL37	-13044.5
RPL22	-13022.5
RPL29	-12825.5
EIF4A2	-12714.5
RPS27	-12488.5
RPL31	-12397.5
EIF3L	-12370.5
RPL8	-11935.5
RPSA	-11874.5
EIF3F	-11823.5
EIF2S2	-11772.5
RPL13A	-11540.0
RPS11	-11531.5
RPS15A	-11448.5
RPS3	-11188.5
RPLP1	-10916.5
EIF4E	-10885.5
RPL23	-10744.5
EIF3G	-10586.5
RPL6	-10548.5
EIF4B	-10147.5
RPL19	-9774.5
RPL5	-9652.5
EIF3A	-9353.5
RPS14	-9097.5
UBA52	-8709.5
RPS26	-8333.5
PABPC1	-8001.5
RPL35A	-7574.5
EIF3C	-7427.5
RPS12	-7221.5
EIF3B	-7198.5
RPS20	-6516.5
EIF2B3	-5013.5
RPS24	-4512.5
RPS7	-4479.5
RPL7A	-4437.5
EIF4G1	-4098.5
RPL24	-4018.5
RPS6	-3673.5
RPL9	-3553.5
RPL3L	-3327.5
EIF4A1	-3299.5
RPL38	-2842.5
RPS8	-2717.5
RPS19	-2624.5
EIF3H	-2468.5
RPL10L	-1873.5
RPL4	-1829.5
RPS17	0.5
RPS9	1795.5
RPL34	2134.5
EIF3E	2645.5
RPL3	3441.5

---

Glucocorticoid biosynthesis

Glucocorticoid biosynthesis

	511
set	Glucocorticoid biosynthesis
setSize	10
pANOVA	0.00957
s.dist	0.473
p.adjustANOVA	0.0241

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HSD3B1	7168.5
HSD11B1	6379.5
CYP11B1	5531.5
CYP17A1	4410.5
HSD3B2	4005.5
SERPINA6	2444.5
CYP21A2	-1524.5
POMC	-1886.5
CYP11B2	-4432.5
HSD11B2	-18349.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HSD3B1	7168.5
HSD11B1	6379.5
CYP11B1	5531.5
CYP17A1	4410.5
HSD3B2	4005.5
SERPINA6	2444.5
CYP21A2	-1524.5
POMC	-1886.5
CYP11B2	-4432.5
HSD11B2	-18349.5

---

Olfactory Signaling Pathway

Olfactory Signaling Pathway

	846
set	Olfactory Signaling Pathway
setSize	372
pANOVA	1.23e-55
s.dist	0.472
p.adjustANOVA	3.75e-53

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR4M2	7194.5
OR7C1	7121.5
OR2Z1	7090.5
OR5H2	7063.5
OR2AG1	7052.5
OR11H4	6994.5
OR12D2	6966.5
OR2AG2	6962.5
OR9Q1	6957.5
OR7E24	6928.5
OR1D2	6918.5
OR8B8	6822.5
OR52I2	6811.5
OR5P2	6800.5
OR6V1	6781.5
OR2M5	6772.5
OR10Q1	6757.5
OR7G1	6727.5
OR4E2	6691.5
OR5A2	6620.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR4M2	7194.5
OR7C1	7121.5
OR2Z1	7090.5
OR5H2	7063.5
OR2AG1	7052.5
OR11H4	6994.5
OR12D2	6966.5
OR2AG2	6962.5
OR9Q1	6957.5
OR7E24	6928.5
OR1D2	6918.5
OR8B8	6822.5
OR52I2	6811.5
OR5P2	6800.5
OR6V1	6781.5
OR2M5	6772.5
OR10Q1	6757.5
OR7G1	6727.5
OR4E2	6691.5
OR5A2	6620.5
OR7D2	6595.5
OR2D2	6562.5
OR7A17	6559.5
OR9A2	6476.5
OR51A7	6469.5
OR4A15	6448.5
OR2L8	6442.5
OR1J4	6405.5
OR2A5	6400.5
OR8H3	6380.5
OR4N2	6305.5
OR8H1	6297.5
OR6B2	6273.5
OR8H2	6232.5
OR13J1	6197.5
OR4C16	6152.5
OR7C2	6122.5
OR7A10	6119.5
OR4C46	6026.5
OR9Q2	6020.5
OR2J3	6000.5
OR10G3	5986.5
OR13C9	5976.5
OR5T2	5974.5
OR6K3	5943.5
OR9I1	5937.5
OR4A47	5933.5
OR2A2	5924.5
OR56A4	5853.5
OR8K1	5849.5
OR10G8	5839.5
OR52A5	5795.5
OR8G2	5794.5
OR8U8	5776.5
OR2AE1	5742.5
OR4N5	5728.5
OR13C8	5722.5
OR2L3	5619.5
OR10H5	5594.5
OR2T5	5581.5
OR1E1	5541.5
OR5AS1	5529.5
OR4K13	5523.5
OR2B2	5513.5
OR2M2	5501.5
OR10H3	5450.5
OR52L1	5383.5
OR5M3	5367.5
OR52E6	5338.5
OR11H6	5335.5
OR6K6	5322.5
OR6C1	5275.5
OR5A1	5262.5
OR2B3	5254.5
OR5M8	5211.5
OR6C75	5195.5
OR10G7	5188.5
OR5M9	5179.5
OR11A1	5157.5
RTP1	5110.5
OR2T33	5099.5
OR5B2	5079.5
OR51T1	5014.5
OR4D5	4991.5
OR2D3	4887.5
OR1B1	4876.5
OR2C1	4842.5
OR5C1	4751.5
OR2V2	4742.5
OR51G1	4639.5
OR4L1	4611.5
OR51B2	4579.5
OR10J1	4516.5
OR8K3	4446.5
OR6C68	4424.5
OR52N1	4354.5
OR52A1	4304.5
OR7D4	4288.5
OR52E8	4245.5
OR8A1	4178.5
OR2J2	4165.5
OR4C6	4086.5
OR5V1	4085.5
OR10AD1	4072.5
OR5I1	4031.5
OR10H1	4028.5
OR14J1	3921.5
OR6N1	3901.5
OR5B3	3725.5
OR4K1	3706.5
OR5L1	3699.5
OR5K3	3689.5
OR6A2	3651.5
OR10G2	3631.5
OR2L2	3625.5
OR13G1	3588.5
OR1N1	3542.5
OR8B4	3527.5
OR10H4	3503.5
OR2V1	3459.5
OR6C65	3428.5
OR7G2	3381.5
OR13C3	3342.5
OR5L2	3305.5
OR10A6	3291.5
OR2L13	3290.5
RTP2	3266.5
OR2Y1	3251.5
OR2K2	3244.5
OR10G9	3207.5
OR1S2	3136.5
OR1A1	3082.5
OR2T29	3052.5
OR1F1	2908.5
OR51F2	2886.5
OR52B6	2788.5
OR10C1	2771.5
OR6F1	2743.5
OR2AK2	2552.5
OR10X1	2546.5
OR1I1	2507.5
OR6N2	2450.5
OR10K1	2331.5
OR6T1	2258.5
OR6X1	2250.5
OR5AP2	2203.5
OR2C3	2059.5
OR6B1	2036.5
OR10V1	2011.5
OR9K2	1986.5
OR1G1	1984.5
OR2F1	1962.5
OR1L3	1940.5
OR51S1	1738.5
OR11G2	1736.5
OR5AU1	1659.5
OR12D3	1624.5
OR56A1	1526.5
OR2T4	1180.5
OR7A5	1159.5
OR5T1	0.5
OR5H1	0.5
OR2S2	0.5
OR2A25	0.5
OR10Z1	0.5
OR8I2	0.5
OR2G6	0.5
OR2A14	0.5
OR9G4	0.5
OR52K2	0.5
OR4S1	0.5
OR2A12	0.5
OR2T2	0.5
OR2AP1	0.5
OR4A16	0.5
OR10K2	0.5
OR4A5	0.5
OR10J5	0.5
OR5D13	0.5
OR51D1	0.5
OR4B1	0.5
OR4N4	0.5
OR51G2	0.5
OR10AG1	0.5
OR2M7	0.5
OR52J3	0.5
OR4K15	0.5
OR2A4	0.5
OR6K2	0.5
OR6B3	0.5
OR5H14	0.5
OR56B4	0.5
OR5B17	0.5
OR6S1	0.5
OR2T35	0.5
OR5AR1	0.5
OR5M11	0.5
OR52N4	0.5
OR7G3	0.5
OR5K1	0.5
OR6C4	0.5
OR4D2	0.5
OR5K4	0.5
OR9A4	0.5
OR5D16	0.5
OR2B11	0.5
OR8J1	0.5
OR4F4	0.5
OR2B6	0.5
OR2G3	0.5
OR51F1	0.5
OR6Y1	0.5
OR5AN1	0.5
OR5M10	0.5
OR1L1	0.5
OR4C12	0.5
OR5P3	0.5
OR6C6	0.5
OR8U1	0.5
OR6M1	0.5
OR5T3	0.5
OR6Q1	0.5
OR14I1	0.5
OR2G2	0.5
OR1D5	0.5
OR1D4	0.5
OR13C4	0.5
OR5B21	0.5
OR51V1	0.5
OR13C2	0.5
OR10A2	0.5
OR13D1	0.5
OR5J2	0.5
OR6C74	0.5
OR52E2	0.5
OR4K14	0.5
OR4C45	0.5
OR4X2	0.5
OR1J1	0.5
OR52N2	0.5
OR4M1	0.5
OR56B1	0.5
OR5AK2	0.5
OR4K17	0.5
OR6C3	0.5
OR1Q1	0.5
OR6C70	0.5
OR6C2	0.5
OR4Q3	0.5
OR4C15	0.5
OR10R2	0.5
OR10T2	0.5
OR2A1	0.5
OR52D1	0.5
OR8B3	0.5
OR2F2	0.5
OR1L4	0.5
OR52N5	0.5
OR52E4	0.5
OR4C13	0.5
OR1L6	0.5
OR1N2	0.5
OR2L5	0.5
OR4D1	-1377.5
OR56A3	-1595.5
OR4F5	-1640.5
OR51E2	-1821.5
OR1E2	-1840.5
OR13A1	-1907.5
OR9G1	-1960.0
OR9G9	-1960.0
OR2M3	-2027.5
OR5AC2	-2115.5
ANO2	-2146.5
OR5D18	-2224.5
OR4F15	-2305.5
OR4F6	-2326.5
OR2T12	-2391.5
OR2W1	-2470.5
OR1C1	-2534.5
OR10H2	-2626.5
OR5H6	-2635.5
OR4D9	-2636.5
OR2H1	-2645.5
OR8B2	-2686.5
OR1K1	-2832.5
OR8D1	-2878.5
OR52K1	-2930.5
OR1S1	-2940.5
OR10A4	-2960.5
OR51I1	-2975.5
OR8J3	-3116.5
OR4D10	-3133.5
OR1A2	-3173.5
OR8D2	-3226.5
OR5D14	-3510.5
OR8K5	-3557.5
OR1J2	-3572.5
OR6P1	-3579.5
GNB1	-3725.5
OR10J3	-3889.5
OR8G1	-3907.5
OR2T8	-4125.5
OR1L8	-4175.5
OR2T34	-4278.5
OR14C36	-4281.5
OR3A3	-4393.5
OR4D11	-4401.5
OR10G4	-4522.5
OR10A3	-4600.5
OR2T11	-4758.5
OR8B12	-4827.5
OR6C76	-5021.5
OR52H1	-5145.5
OR4K5	-5292.5
OR5W2	-5347.5
OR51L1	-5351.5
OR1M1	-5382.5
ADCY3	-5413.5
OR2W3	-5508.5
OR8S1	-5701.5
OR2T1	-5729.5
OR8D4	-5819.5
OR4X1	-5875.5
OR51B4	-6018.5
OR10A5	-6066.5
OR2W5	-6201.5
OR51B6	-6216.5
OR4D6	-6329.5
OR2T3	-6386.5
OR3A1	-6391.5
OR2T6	-6535.5
OR11L1	-6591.5
EBF1	-6636.5
OR10P1	-6780.5
OR2T27	-6970.5
OR56A5	-7005.5
OR10W1	-7019.5
OR5F1	-7293.5
OR5B12	-7356.5
OR3A2	-7445.5
OR51A2	-7471.5
OR8G5	-7780.5
OR14A16	-7878.5
OR10S1	-8147.5
OR52R1	-8408.5
OR2H2	-8458.5
OR4K2	-8511.5
OR51E1	-8538.5
OR5K2	-8625.5
OR5R1	-8805.5
CNGB1	-9165.5
OR10A7	-9200.5
OR52B2	-9386.5
OR13F1	-9402.5
OR2AT4	-9727.5
CNGA4	-9804.5
OR51Q1	-10195.5
OR2M4	-10200.5
OR52I1	-10230.5
OR51B5	-10430.5
OR52W1	-10485.5
OR51M1	-10934.5
OR4C3	-11001.5
GNAL	-11150.5
OR52M1	-11632.5
OR5M1	-11648.5
LHX2	-13379.5
GNG13	-13866.5
OR51I2	-15582.5
REEP1	-15890.5
LDB1	-18364.5

---

RNA Pol II CTD phosphorylation and interaction with CE

RNA Pol II CTD phosphorylation and interaction with CE

	1016
set	RNA Pol II CTD phosphorylation and interaction with CE
setSize	26
pANOVA	3.03e-05
s.dist	-0.472
p.adjustANOVA	0.000152

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2D	-18309.5
POLR2I	-17740.5
POLR2L	-17726.5
RNMT	-17716.5
GTF2F1	-17225.5
SUPT5H	-17160.5
CCNH	-16122.5
POLR2A	-15976.5
GTF2H1	-15658.5
POLR2B	-15522.5
GTF2H5	-15491.5
GTF2H3	-15207.5
POLR2F	-15151.5
POLR2C	-14409.5
POLR2E	-13593.5
CDK7	-12405.5
GTF2H4	-11975.5
POLR2K	-11800.5
POLR2G	-11643.5
POLR2H	-10479.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2D	-18309.5
POLR2I	-17740.5
POLR2L	-17726.5
RNMT	-17716.5
GTF2F1	-17225.5
SUPT5H	-17160.5
CCNH	-16122.5
POLR2A	-15976.5
GTF2H1	-15658.5
POLR2B	-15522.5
GTF2H5	-15491.5
GTF2H3	-15207.5
POLR2F	-15151.5
POLR2C	-14409.5
POLR2E	-13593.5
CDK7	-12405.5
GTF2H4	-11975.5
POLR2K	-11800.5
POLR2G	-11643.5
POLR2H	-10479.5
ERCC2	-8987.5
POLR2J	-7501.5
GTF2F2	-5589.5
RNGTT	2619.5
ERCC3	4351.5
MNAT1	5060.5

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report