Mitch Report

date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##           metric
## HOXC4 -20.409676
## DAB1   -9.785635
## PDE4D  -8.885264
## PAX6  -13.516826
## IRX4  -18.417743
## BRD2  -11.070393

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2546
num_genes_in_profile	26148
duplicated_genes_present	0
num_profile_genes_in_sets	10252
num_profile_genes_not_in_sets	15896

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1018
num_genesets_included	1528

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	8.76e-05	-0.683	3.19e-04
Folding of actin by CCT/TriC	10	3.21e-04	-0.657	1.02e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	4.41e-04	-0.642	1.34e-03
FOXO-mediated transcription of cell cycle genes	16	1.14e-05	-0.633	5.38e-05
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	6.49e-05	-0.616	2.42e-04
Crosslinking of collagen fibrils	10	9.19e-04	-0.605	2.56e-03
Beta defensins	32	4.06e-09	0.600	4.37e-08
Processing of Intronless Pre-mRNAs	19	5.84e-06	-0.600	2.96e-05
RUNX3 regulates p14-ARF	10	1.03e-03	-0.599	2.84e-03
Defensins	40	1.94e-10	0.581	2.41e-09
Disorders of Developmental Biology	11	1.20e-03	-0.564	3.17e-03
Disorders of Nervous System Development	11	1.20e-03	-0.564	3.17e-03
Loss of function of MECP2 in Rett syndrome	11	1.20e-03	-0.564	3.17e-03
Pervasive developmental disorders	11	1.20e-03	-0.564	3.17e-03
Processing of Capped Intronless Pre-mRNA	28	2.76e-07	-0.561	2.03e-06
Beta-catenin phosphorylation cascade	16	1.32e-04	-0.552	4.64e-04
RAF-independent MAPK1/3 activation	22	7.82e-06	-0.550	3.84e-05
Regulated proteolysis of p75NTR	11	1.81e-03	-0.543	4.48e-03
Repression of WNT target genes	13	7.78e-04	-0.538	2.19e-03
FGFR2 alternative splicing	26	2.90e-06	-0.530	1.63e-05
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	2.72e-03	-0.522	6.38e-03
SUMOylation of immune response proteins	10	4.34e-03	-0.521	9.55e-03
ERKs are inactivated	13	1.16e-03	-0.520	3.12e-03
Activation of the TFAP2 (AP-2) family of transcription factors	11	3.28e-03	-0.512	7.55e-03
Transcriptional regulation of testis differentiation	12	2.24e-03	-0.509	5.44e-03
NGF-stimulated transcription	39	4.08e-08	-0.507	3.80e-07
Expression and translocation of olfactory receptors	365	1.20e-62	0.507	3.66e-60
Antimicrobial peptides	82	2.06e-15	0.506	5.82e-14
Glucocorticoid biosynthesis	10	5.73e-03	0.504	1.20e-02
Signaling by FGFR2 IIIa TM	19	1.76e-04	-0.497	6.00e-04
Condensation of Prometaphase Chromosomes	11	4.37e-03	-0.496	9.58e-03
CTNNB1 S33 mutants aren’t phosphorylated	14	1.32e-03	-0.496	3.42e-03
CTNNB1 S37 mutants aren’t phosphorylated	14	1.32e-03	-0.496	3.42e-03
CTNNB1 S45 mutants aren’t phosphorylated	14	1.32e-03	-0.496	3.42e-03
CTNNB1 T41 mutants aren’t phosphorylated	14	1.32e-03	-0.496	3.42e-03
Signaling by CTNNB1 phospho-site mutants	14	1.32e-03	-0.496	3.42e-03
Signaling by GSK3beta mutants	14	1.32e-03	-0.496	3.42e-03
Digestion of dietary carbohydrate	10	6.73e-03	0.495	1.38e-02
SLBP independent Processing of Histone Pre-mRNAs	10	6.76e-03	-0.494	1.39e-02
Initiation of Nuclear Envelope (NE) Reformation	18	2.82e-04	-0.494	9.18e-04
Inhibition of DNA recombination at telomere	20	1.31e-04	-0.494	4.59e-04
RNA Polymerase III Transcription Termination	23	4.35e-05	-0.492	1.75e-04
Olfactory Signaling Pathway	372	4.29e-60	0.492	9.36e-58
ERK/MAPK targets	20	1.48e-04	-0.490	5.12e-04
APC truncation mutants have impaired AXIN binding	13	2.50e-03	-0.484	5.93e-03
AXIN missense mutants destabilize the destruction complex	13	2.50e-03	-0.484	5.93e-03
Signaling by AMER1 mutants	13	2.50e-03	-0.484	5.93e-03
Signaling by APC mutants	13	2.50e-03	-0.484	5.93e-03
Signaling by AXIN mutants	13	2.50e-03	-0.484	5.93e-03
Truncations of AMER1 destabilize the destruction complex	13	2.50e-03	-0.484	5.93e-03

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	8.76e-05	-0.683000	3.19e-04
Folding of actin by CCT/TriC	10	3.21e-04	-0.657000	1.02e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	4.41e-04	-0.642000	1.34e-03
FOXO-mediated transcription of cell cycle genes	16	1.14e-05	-0.633000	5.38e-05
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	6.49e-05	-0.616000	2.42e-04
Crosslinking of collagen fibrils	10	9.19e-04	-0.605000	2.56e-03
Beta defensins	32	4.06e-09	0.600000	4.37e-08
Processing of Intronless Pre-mRNAs	19	5.84e-06	-0.600000	2.96e-05
RUNX3 regulates p14-ARF	10	1.03e-03	-0.599000	2.84e-03
Defensins	40	1.94e-10	0.581000	2.41e-09
Disorders of Developmental Biology	11	1.20e-03	-0.564000	3.17e-03
Disorders of Nervous System Development	11	1.20e-03	-0.564000	3.17e-03
Loss of function of MECP2 in Rett syndrome	11	1.20e-03	-0.564000	3.17e-03
Pervasive developmental disorders	11	1.20e-03	-0.564000	3.17e-03
Processing of Capped Intronless Pre-mRNA	28	2.76e-07	-0.561000	2.03e-06
Beta-catenin phosphorylation cascade	16	1.32e-04	-0.552000	4.64e-04
RAF-independent MAPK1/3 activation	22	7.82e-06	-0.550000	3.84e-05
Regulated proteolysis of p75NTR	11	1.81e-03	-0.543000	4.48e-03
Repression of WNT target genes	13	7.78e-04	-0.538000	2.19e-03
FGFR2 alternative splicing	26	2.90e-06	-0.530000	1.63e-05
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	2.72e-03	-0.522000	6.38e-03
SUMOylation of immune response proteins	10	4.34e-03	-0.521000	9.55e-03
ERKs are inactivated	13	1.16e-03	-0.520000	3.12e-03
Activation of the TFAP2 (AP-2) family of transcription factors	11	3.28e-03	-0.512000	7.55e-03
Transcriptional regulation of testis differentiation	12	2.24e-03	-0.509000	5.44e-03
NGF-stimulated transcription	39	4.08e-08	-0.507000	3.80e-07
Expression and translocation of olfactory receptors	365	1.20e-62	0.507000	3.66e-60
Antimicrobial peptides	82	2.06e-15	0.506000	5.82e-14
Glucocorticoid biosynthesis	10	5.73e-03	0.504000	1.20e-02
Signaling by FGFR2 IIIa TM	19	1.76e-04	-0.497000	6.00e-04
Condensation of Prometaphase Chromosomes	11	4.37e-03	-0.496000	9.58e-03
CTNNB1 S33 mutants aren’t phosphorylated	14	1.32e-03	-0.496000	3.42e-03
CTNNB1 S37 mutants aren’t phosphorylated	14	1.32e-03	-0.496000	3.42e-03
CTNNB1 S45 mutants aren’t phosphorylated	14	1.32e-03	-0.496000	3.42e-03
CTNNB1 T41 mutants aren’t phosphorylated	14	1.32e-03	-0.496000	3.42e-03
Signaling by CTNNB1 phospho-site mutants	14	1.32e-03	-0.496000	3.42e-03
Signaling by GSK3beta mutants	14	1.32e-03	-0.496000	3.42e-03
Digestion of dietary carbohydrate	10	6.73e-03	0.495000	1.38e-02
SLBP independent Processing of Histone Pre-mRNAs	10	6.76e-03	-0.494000	1.39e-02
Initiation of Nuclear Envelope (NE) Reformation	18	2.82e-04	-0.494000	9.18e-04
Inhibition of DNA recombination at telomere	20	1.31e-04	-0.494000	4.59e-04
RNA Polymerase III Transcription Termination	23	4.35e-05	-0.492000	1.75e-04
Olfactory Signaling Pathway	372	4.29e-60	0.492000	9.36e-58
ERK/MAPK targets	20	1.48e-04	-0.490000	5.12e-04
APC truncation mutants have impaired AXIN binding	13	2.50e-03	-0.484000	5.93e-03
AXIN missense mutants destabilize the destruction complex	13	2.50e-03	-0.484000	5.93e-03
Signaling by AMER1 mutants	13	2.50e-03	-0.484000	5.93e-03
Signaling by APC mutants	13	2.50e-03	-0.484000	5.93e-03
Signaling by AXIN mutants	13	2.50e-03	-0.484000	5.93e-03
Truncations of AMER1 destabilize the destruction complex	13	2.50e-03	-0.484000	5.93e-03
RNA Polymerase III Chain Elongation	18	3.80e-04	-0.484000	1.18e-03
mRNA Capping	28	9.48e-06	-0.483000	4.57e-05
RMTs methylate histone arginines	29	6.94e-06	-0.482000	3.44e-05
Signaling by PDGFRA extracellular domain mutants	12	3.83e-03	-0.482000	8.63e-03
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	3.83e-03	-0.482000	8.63e-03
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	4.01e-03	-0.480000	8.95e-03
Nuclear Events (kinase and transcription factor activation)	60	1.30e-10	-0.479000	1.64e-09
Signaling by ALK	26	2.38e-05	-0.479000	1.02e-04
Diseases associated with glycosylation precursor biosynthesis	15	1.37e-03	-0.477000	3.55e-03
Activation of HOX genes during differentiation	61	1.26e-10	-0.476000	1.60e-09
Activation of anterior HOX genes in hindbrain development during early embryogenesis	61	1.26e-10	-0.476000	1.60e-09
FOXO-mediated transcription of cell death genes	15	1.47e-03	-0.474000	3.76e-03
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	2.05e-05	-0.473000	8.90e-05
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	4.64e-03	-0.472000	1.01e-02
alpha-linolenic acid (ALA) metabolism	12	4.64e-03	-0.472000	1.01e-02
SUMOylation of transcription factors	20	3.04e-04	-0.466000	9.69e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	3.60e-03	-0.466000	8.18e-03
Defective pyroptosis	11	7.47e-03	-0.466000	1.51e-02
RNA Pol II CTD phosphorylation and interaction with CE	26	4.08e-05	-0.465000	1.66e-04
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	4.08e-05	-0.465000	1.66e-04
Cleavage of the damaged purine	11	7.68e-03	-0.464000	1.54e-02
Depurination	11	7.68e-03	-0.464000	1.54e-02
Recognition and association of DNA glycosylase with site containing an affected purine	11	7.68e-03	-0.464000	1.54e-02
Association of TriC/CCT with target proteins during biosynthesis	38	7.58e-07	-0.463000	4.89e-06
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	1.14e-02	-0.462000	2.16e-02
Diseases associated with N-glycosylation of proteins	19	5.02e-04	-0.461000	1.49e-03
DNA Damage/Telomere Stress Induced Senescence	28	3.38e-05	-0.452000	1.41e-04
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	4.14e-05	-0.447000	1.68e-04
Acetylcholine Neurotransmitter Release Cycle	16	1.94e-03	-0.447000	4.79e-03
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	22	2.83e-04	-0.447000	9.18e-04
Neurodegenerative Diseases	22	2.83e-04	-0.447000	9.18e-04
SCF(Skp2)-mediated degradation of p27/p21	58	3.88e-09	-0.447000	4.20e-08
mRNA decay by 5’ to 3’ exoribonuclease	15	2.73e-03	-0.447000	6.39e-03
RUNX2 regulates osteoblast differentiation	22	2.99e-04	-0.445000	9.59e-04
Uptake and function of anthrax toxins	11	1.06e-02	-0.445000	2.02e-02
Purine ribonucleoside monophosphate biosynthesis	11	1.08e-02	-0.444000	2.05e-02
NRIF signals cell death from the nucleus	16	2.12e-03	-0.443000	5.19e-03
RUNX2 regulates bone development	29	3.69e-05	-0.442000	1.52e-04
Base-Excision Repair, AP Site Formation	18	1.16e-03	-0.442000	3.12e-03
Mitochondrial translation	93	1.77e-13	-0.441000	3.56e-12
Defective Intrinsic Pathway for Apoptosis	25	1.35e-04	-0.441000	4.70e-04
Mitochondrial translation termination	87	1.19e-12	-0.440000	2.17e-11
Translation	263	8.79e-35	-0.439000	7.07e-33
Serotonin Neurotransmitter Release Cycle	16	2.39e-03	-0.438000	5.75e-03
RHO GTPases Activate Formins	114	5.93e-16	-0.438000	1.81e-14
Leading Strand Synthesis	13	6.23e-03	-0.438000	1.29e-02
Polymerase switching	13	6.23e-03	-0.438000	1.29e-02
Metabolism of cofactors	19	9.89e-04	-0.436000	2.72e-03
Signaling by NOTCH4	79	2.02e-11	-0.436000	2.86e-10
Mitochondrial translation initiation	87	2.34e-12	-0.434000	4.02e-11
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	1.74e-02	-0.434000	3.06e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	4.51e-04	-0.432000	1.36e-03
Early Phase of HIV Life Cycle	14	5.14e-03	-0.432000	1.10e-02
Mitochondrial tRNA aminoacylation	18	1.58e-03	-0.430000	4.01e-03
Resolution of Sister Chromatid Cohesion	98	2.00e-13	-0.429000	3.93e-12
Polymerase switching on the C-strand of the telomere	24	2.80e-04	-0.428000	9.14e-04
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	2.24e-03	-0.428000	5.44e-03
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	2.24e-03	-0.428000	5.44e-03
Negative regulation of NOTCH4 signaling	52	9.25e-08	-0.428000	7.77e-07
DARPP-32 events	24	2.85e-04	-0.428000	9.22e-04
Cyclin A/B1/B2 associated events during G2/M transition	24	2.86e-04	-0.428000	9.24e-04
Nephrin family interactions	21	7.15e-04	-0.426000	2.04e-03
Mitochondrial translation elongation	87	7.19e-12	-0.425000	1.14e-10
Diseases of programmed cell death	41	2.90e-06	-0.422000	1.63e-05
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	4.69e-03	-0.422000	1.02e-02
tRNA Aminoacylation	24	3.63e-04	-0.420000	1.14e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	89	6.98e-12	-0.420000	1.12e-10
Amplification of signal from the kinetochores	89	6.98e-12	-0.420000	1.12e-10
Degradation of beta-catenin by the destruction complex	81	6.38e-11	-0.420000	8.56e-10
Activation of the AP-1 family of transcription factors	10	2.16e-02	-0.420000	3.68e-02
Dopamine Neurotransmitter Release Cycle	20	1.18e-03	-0.419000	3.16e-03
Condensation of Prophase Chromosomes	12	1.20e-02	-0.419000	2.25e-02
RHO GTPases activate IQGAPs	11	1.64e-02	-0.418000	2.90e-02
SRP-dependent cotranslational protein targeting to membrane	105	1.40e-13	-0.417000	2.85e-12
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	3.40e-07	-0.417000	2.43e-06
Cyclin A:Cdk2-associated events at S phase entry	83	5.22e-11	-0.416000	7.05e-10
Interleukin-35 Signalling	12	1.25e-02	-0.416000	2.34e-02
MET receptor recycling	10	2.27e-02	-0.416000	3.83e-02
Cyclin E associated events during G1/S transition	81	9.28e-11	-0.416000	1.22e-09
Interleukin-27 signaling	11	1.71e-02	-0.415000	3.02e-02
Physiological factors	12	1.28e-02	-0.415000	2.38e-02
Sulfur amino acid metabolism	27	1.89e-04	-0.415000	6.36e-04
Signaling by Activin	15	5.46e-03	-0.414000	1.16e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	5.69e-03	-0.412000	1.20e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	5.69e-03	-0.412000	1.20e-02
Mitochondrial protein import	54	1.63e-07	-0.412000	1.28e-06
eNOS activation	11	1.80e-02	-0.412000	3.16e-02
Signal attenuation	10	2.43e-02	-0.411000	4.03e-02
Signaling by NTRK1 (TRKA)	114	3.52e-14	-0.410000	8.40e-13
Norepinephrine Neurotransmitter Release Cycle	16	4.48e-03	-0.410000	9.79e-03
FGFR2 mutant receptor activation	32	6.09e-05	-0.409000	2.31e-04
Signaling by FGFR2 in disease	42	4.44e-06	-0.409000	2.41e-05
Diseases of DNA repair	49	7.66e-07	-0.408000	4.92e-06
Cap-dependent Translation Initiation	112	8.31e-14	-0.408000	1.81e-12
Eukaryotic Translation Initiation	112	8.31e-14	-0.408000	1.81e-12
Eukaryotic Translation Elongation	88	4.02e-11	-0.407000	5.48e-10
RIP-mediated NFkB activation via ZBP1	16	4.83e-03	-0.407000	1.04e-02
Endosomal/Vacuolar pathway	12	1.48e-02	-0.406000	2.66e-02
Formation of the beta-catenin:TCF transactivating complex	32	7.50e-05	-0.404000	2.78e-04
Platelet sensitization by LDL	17	3.89e-03	-0.404000	8.74e-03
MAPK targets/ Nuclear events mediated by MAP kinases	29	1.65e-04	-0.404000	5.68e-04
TP53 Regulates Transcription of Cell Cycle Genes	49	1.02e-06	-0.403000	6.32e-06
EML4 and NUDC in mitotic spindle formation	93	1.71e-11	-0.403000	2.46e-10
HIV Transcription Initiation	43	4.87e-06	-0.403000	2.55e-05
RNA Polymerase II HIV Promoter Escape	43	4.87e-06	-0.403000	2.55e-05
RNA Polymerase II Promoter Escape	43	4.87e-06	-0.403000	2.55e-05
RNA Polymerase II Transcription Initiation	43	4.87e-06	-0.403000	2.55e-05
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	4.87e-06	-0.403000	2.55e-05
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	4.87e-06	-0.403000	2.55e-05
Impaired BRCA2 binding to RAD51	33	6.27e-05	-0.402000	2.36e-04
ZBP1(DAI) mediated induction of type I IFNs	20	1.84e-03	-0.402000	4.54e-03
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	21	1.42e-03	-0.402000	3.64e-03
Downstream signal transduction	29	1.78e-04	-0.402000	6.07e-04
Activation of SMO	17	4.12e-03	-0.402000	9.19e-03
G0 and Early G1	27	3.16e-04	-0.400000	1.01e-03
RET signaling	41	9.41e-06	-0.400000	4.55e-05
Asymmetric localization of PCP proteins	62	5.33e-08	-0.399000	4.80e-07
Regulation of expression of SLITs and ROBOs	159	4.12e-18	-0.398000	1.62e-16
Cleavage of the damaged pyrimidine	16	5.82e-03	-0.398000	1.21e-02
Depyrimidination	16	5.82e-03	-0.398000	1.21e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	5.82e-03	-0.398000	1.21e-02
Transcriptional regulation of granulopoiesis	31	1.28e-04	-0.397000	4.52e-04
TP53 Regulates Transcription of DNA Repair Genes	57	2.10e-07	-0.397000	1.59e-06
Downstream signaling of activated FGFR4	26	4.63e-04	-0.396000	1.39e-03
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	4.75e-07	-0.396000	3.18e-06
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	4.75e-07	-0.396000	3.18e-06
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	4.75e-07	-0.396000	3.18e-06
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	4.75e-07	-0.396000	3.18e-06
Signaling by NOTCH1 in Cancer	54	4.75e-07	-0.396000	3.18e-06
Translesion synthesis by POLI	17	4.70e-03	-0.396000	1.02e-02
Mitochondrial iron-sulfur cluster biogenesis	12	1.76e-02	-0.396000	3.09e-02
Negative epigenetic regulation of rRNA expression	45	4.51e-06	-0.395000	2.44e-05
Metabolism of Angiotensinogen to Angiotensins	15	8.21e-03	0.394000	1.62e-02
Defects in cobalamin (B12) metabolism	12	1.83e-02	-0.393000	3.18e-02
HDACs deacetylate histones	29	2.44e-04	-0.393000	8.06e-04
GTP hydrolysis and joining of the 60S ribosomal subunit	105	3.29e-12	-0.393000	5.54e-11
PI-3K cascade:FGFR4	19	3.06e-03	-0.392000	7.05e-03
Interaction With Cumulus Cells And The Zona Pellucida	11	2.43e-02	0.392000	4.03e-02
Formation of a pool of free 40S subunits	95	3.89e-11	-0.392000	5.36e-10
EPH-ephrin mediated repulsion of cells	48	2.65e-06	-0.392000	1.50e-05
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	108	1.96e-12	-0.391000	3.45e-11
Nonsense-Mediated Decay (NMD)	108	1.96e-12	-0.391000	3.45e-11
Viral mRNA Translation	84	5.44e-10	-0.391000	6.49e-09
MAPK3 (ERK1) activation	10	3.21e-02	-0.391000	5.10e-02
MicroRNA (miRNA) biogenesis	26	5.56e-04	-0.391000	1.63e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	1.79e-06	-0.390000	1.05e-05
p53-Independent DNA Damage Response	50	1.79e-06	-0.390000	1.05e-05
p53-Independent G1/S DNA damage checkpoint	50	1.79e-06	-0.390000	1.05e-05
Downstream signaling of activated FGFR3	24	9.32e-04	-0.390000	2.59e-03
Signaling by PDGFR in disease	20	2.52e-03	-0.390000	5.98e-03
G1/S DNA Damage Checkpoints	66	4.34e-08	-0.390000	4.02e-07
G1/S Transition	126	4.11e-14	-0.389000	9.65e-13
RNA Polymerase III Abortive And Retractive Initiation	41	1.62e-05	-0.389000	7.23e-05
RNA Polymerase III Transcription	41	1.62e-05	-0.389000	7.23e-05
Eukaryotic Translation Termination	87	3.57e-10	-0.389000	4.36e-09
Peptide chain elongation	84	7.34e-10	-0.388000	8.69e-09
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	34	9.09e-05	-0.388000	3.29e-04
Transcriptional regulation by RUNX3	93	1.02e-10	-0.387000	1.33e-09
Ubiquitin-dependent degradation of Cyclin D	50	2.21e-06	-0.387000	1.27e-05
Estrogen-dependent gene expression	91	1.75e-10	-0.387000	2.19e-09
p53-Dependent G1 DNA Damage Response	64	8.72e-08	-0.387000	7.36e-07
p53-Dependent G1/S DNA damage checkpoint	64	8.72e-08	-0.387000	7.36e-07
Cytosolic iron-sulfur cluster assembly	10	3.43e-02	-0.386000	5.40e-02
Neurotoxicity of clostridium toxins	10	3.44e-02	-0.386000	5.41e-02
Gap junction degradation	10	3.48e-02	-0.385000	5.45e-02
Transcriptional regulation of pluripotent stem cells	30	2.62e-04	-0.385000	8.60e-04
tRNA processing in the nucleus	55	7.81e-07	-0.385000	4.98e-06
TRAF6 mediated NF-kB activation	24	1.10e-03	-0.385000	2.99e-03
RNA Polymerase I Promoter Escape	28	4.35e-04	-0.384000	1.32e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	1.02e-10	-0.383000	1.33e-09
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	3.82e-03	-0.383000	8.63e-03
PI-3K cascade:FGFR3	17	6.25e-03	-0.383000	1.30e-02
L13a-mediated translational silencing of Ceruloplasmin expression	104	1.44e-11	-0.383000	2.16e-10
Degradation of AXIN	53	1.44e-06	-0.382000	8.77e-06
Formation of HIV elongation complex in the absence of HIV Tat	40	2.83e-05	-0.382000	1.19e-04
Telomere C-strand synthesis initiation	11	2.82e-02	-0.382000	4.56e-02
Interleukin-6 signaling	11	2.83e-02	-0.382000	4.57e-02
NOTCH4 Intracellular Domain Regulates Transcription	19	3.96e-03	-0.382000	8.86e-03
Formation of HIV-1 elongation complex containing HIV-1 Tat	38	4.67e-05	-0.381000	1.86e-04
HIV Transcription Elongation	38	4.67e-05	-0.381000	1.86e-04
Tat-mediated elongation of the HIV-1 transcript	38	4.67e-05	-0.381000	1.86e-04
EGR2 and SOX10-mediated initiation of Schwann cell myelination	27	6.01e-04	-0.381000	1.75e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	4.91e-10	-0.381000	5.91e-09
Separation of Sister Chromatids	161	6.33e-17	-0.381000	2.15e-15
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	44	1.20e-05	-0.381000	5.59e-05
Response of EIF2AK1 (HRI) to heme deficiency	14	1.35e-02	-0.381000	2.50e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	1.91e-04	-0.381000	6.40e-04
Regulation of RUNX3 expression and activity	53	1.62e-06	-0.381000	9.62e-06
Viral Messenger RNA Synthesis	42	1.99e-05	-0.380000	8.67e-05
RUNX1 regulates transcription of genes involved in differentiation of HSCs	68	5.80e-08	-0.380000	5.15e-07
Transport of Mature mRNAs Derived from Intronless Transcripts	41	2.51e-05	-0.380000	1.07e-04
Keratinization	214	8.31e-22	0.380000	3.97e-20
RHO GTPases activate CIT	19	4.15e-03	-0.380000	9.23e-03
Dual incision in TC-NER	63	1.86e-07	-0.379000	1.44e-06
Telomere Maintenance	62	2.34e-07	-0.379000	1.76e-06
HDR through Single Strand Annealing (SSA)	36	8.15e-05	-0.379000	2.98e-04
Signaling by WNT in cancer	32	2.04e-04	-0.379000	6.82e-04
Influenza Viral RNA Transcription and Replication	129	9.78e-14	-0.379000	2.05e-12
Transcriptional regulation by RUNX2	116	1.69e-12	-0.379000	3.04e-11
NoRC negatively regulates rRNA expression	43	1.74e-05	-0.378000	7.62e-05
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27	6.64e-04	-0.378000	1.91e-03
Mitotic Spindle Checkpoint	106	1.67e-11	-0.378000	2.45e-10
HS-GAG biosynthesis	28	5.32e-04	-0.378000	1.57e-03
Signaling by NOTCH1	70	4.49e-08	-0.378000	4.13e-07
Mitotic G1 phase and G1/S transition	144	4.80e-15	-0.378000	1.29e-13
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37	7.04e-05	-0.377000	2.62e-04
Abortive elongation of HIV-1 transcript in the absence of Tat	23	1.73e-03	-0.377000	4.30e-03
Regulation of Apoptosis	51	3.21e-06	-0.377000	1.77e-05
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	4.69e-05	-0.376000	1.86e-04
Diseases of DNA Double-Strand Break Repair	39	4.69e-05	-0.376000	1.86e-04
NOTCH1 Intracellular Domain Regulates Transcription	44	1.54e-05	-0.376000	6.95e-05
Hh mutants abrogate ligand secretion	57	8.74e-07	-0.376000	5.52e-06
Autodegradation of the E3 ubiquitin ligase COP1	50	4.17e-06	-0.376000	2.27e-05
HIV elongation arrest and recovery	29	4.58e-04	-0.376000	1.38e-03
Pausing and recovery of HIV elongation	29	4.58e-04	-0.376000	1.38e-03
Signaling by NTRKs	133	7.14e-14	-0.375000	1.65e-12
Metabolism of polyamines	55	1.49e-06	-0.375000	9.04e-06
KSRP (KHSRP) binds and destabilizes mRNA	17	7.45e-03	-0.375000	1.51e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	2.35e-06	-0.375000	1.35e-05
Signaling by ROBO receptors	203	3.15e-20	-0.374000	1.38e-18
Degradation of cysteine and homocysteine	14	1.53e-02	-0.374000	2.75e-02
Heme biosynthesis	13	1.94e-02	-0.374000	3.37e-02
Metabolism of folate and pterines	16	9.54e-03	-0.374000	1.85e-02
Pausing and recovery of Tat-mediated HIV elongation	27	7.62e-04	-0.374000	2.15e-03
Tat-mediated HIV elongation arrest and recovery	27	7.62e-04	-0.374000	2.15e-03
Signaling by NTRK2 (TRKB)	25	1.21e-03	-0.374000	3.18e-03
Postmitotic nuclear pore complex (NPC) reformation	26	9.69e-04	-0.374000	2.68e-03
TCF dependent signaling in response to WNT	168	5.82e-17	-0.374000	2.02e-15
Downregulation of SMAD2/3:SMAD4 transcriptional activity	26	9.84e-04	-0.373000	2.71e-03
Regulation of RAS by GAPs	66	1.57e-07	-0.373000	1.25e-06
HDR through MMEJ (alt-NHEJ)	11	3.22e-02	-0.373000	5.10e-02
Formation of TC-NER Pre-Incision Complex	51	4.04e-06	-0.373000	2.21e-05
Hh mutants are degraded by ERAD	54	2.14e-06	-0.373000	1.23e-05
GLI3 is processed to GLI3R by the proteasome	58	9.23e-07	-0.372000	5.81e-06
Activation of AMPK downstream of NMDARs	10	4.17e-02	-0.372000	6.37e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	2.59e-02	-0.371000	4.21e-02
Defective EXT2 causes exostoses 2	12	2.59e-02	-0.371000	4.21e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	1.29e-02	-0.371000	2.39e-02
SCF-beta-TrCP mediated degradation of Emi1	53	2.97e-06	-0.371000	1.66e-05
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	4.58e-06	-0.371000	2.45e-05
Presynaptic phase of homologous DNA pairing and strand exchange	38	7.60e-05	-0.371000	2.81e-04
Selenocysteine synthesis	87	2.24e-09	-0.371000	2.55e-08
RNA Polymerase III Transcription Initiation	36	1.20e-04	-0.370000	4.28e-04
Translesion synthesis by REV1	16	1.04e-02	-0.370000	1.98e-02
Influenza Infection	148	7.18e-15	-0.370000	1.89e-13
Regulation of ornithine decarboxylase (ODC)	49	7.33e-06	-0.370000	3.62e-05
Vpu mediated degradation of CD4	50	5.95e-06	-0.370000	3.00e-05
Transport of Mature mRNA Derived from an Intronless Transcript	40	5.16e-05	-0.370000	2.02e-04
Hedgehog ligand biogenesis	63	3.94e-07	-0.369000	2.72e-06
FGFRL1 modulation of FGFR1 signaling	13	2.12e-02	-0.369000	3.63e-02
Activation of ATR in response to replication stress	37	1.02e-04	-0.369000	3.67e-04
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	4.72e-04	-0.369000	1.41e-03
Regulation of RUNX2 expression and activity	71	7.66e-08	-0.369000	6.65e-07
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	62	5.27e-07	-0.368000	3.52e-06
Fatty acids	15	1.36e-02	0.368000	2.51e-02
Mitotic Prometaphase	175	4.33e-17	-0.368000	1.54e-15
EPHB-mediated forward signaling	34	2.09e-04	-0.367000	6.96e-04
Polo-like kinase mediated events	16	1.11e-02	-0.367000	2.11e-02
PCP/CE pathway	90	1.80e-09	-0.367000	2.10e-08
Transcription of the HIV genome	62	5.96e-07	-0.366000	3.94e-06
PRC2 methylates histones and DNA	13	2.22e-02	-0.366000	3.78e-02
Cell Cycle Checkpoints	248	2.54e-23	-0.366000	1.29e-21
The role of GTSE1 in G2/M progression after G2 checkpoint	58	1.40e-06	-0.366000	8.57e-06
XBP1(S) activates chaperone genes	48	1.15e-05	-0.366000	5.38e-05
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	2.84e-02	-0.365000	4.59e-02
Cellular response to hypoxia	71	1.04e-07	-0.365000	8.59e-07
G2/M DNA damage checkpoint	58	1.54e-06	-0.365000	9.29e-06
Defects in vitamin and cofactor metabolism	20	4.79e-03	-0.364000	1.04e-02
Formation of the Early Elongation Complex	32	3.77e-04	-0.363000	1.17e-03
Formation of the HIV-1 Early Elongation Complex	32	3.77e-04	-0.363000	1.17e-03
Synthesis of glycosylphosphatidylinositol (GPI)	17	9.57e-03	-0.363000	1.85e-02
Digestion and absorption	26	1.36e-03	0.363000	3.54e-03
Prefoldin mediated transfer of substrate to CCT/TriC	27	1.12e-03	-0.362000	3.02e-03
B-WICH complex positively regulates rRNA expression	29	7.41e-04	-0.362000	2.10e-03
Transcriptional regulation by small RNAs	46	2.17e-05	-0.362000	9.36e-05
RND1 GTPase cycle	41	6.15e-05	-0.361000	2.33e-04
TNFR1-induced proapoptotic signaling	13	2.41e-02	-0.361000	4.00e-02
Glutathione synthesis and recycling	13	2.42e-02	-0.361000	4.01e-02
APC/C:Cdc20 mediated degradation of mitotic proteins	74	7.87e-08	-0.361000	6.79e-07
TRAF3-dependent IRF activation pathway	15	1.56e-02	-0.360000	2.81e-02
Activated NTRK2 signals through FRS2 and FRS3	11	3.86e-02	-0.360000	5.96e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	2.47e-02	-0.360000	4.05e-02
HDMs demethylate histones	18	8.23e-03	-0.360000	1.62e-02
Vif-mediated degradation of APOBEC3G	50	1.10e-05	-0.359000	5.22e-05
Role of LAT2/NTAL/LAB on calcium mobilization	13	2.49e-02	-0.359000	4.08e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	7.53e-08	-0.359000	6.58e-07
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	1.67e-07	-0.359000	1.31e-06
Negative regulation of MAPK pathway	41	6.96e-05	-0.359000	2.59e-04
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	1.72e-05	-0.358000	7.55e-05
Gap-filling DNA repair synthesis and ligation in TC-NER	62	1.08e-06	-0.358000	6.66e-06
Formation of RNA Pol II elongation complex	53	6.52e-06	-0.358000	3.26e-05
RNA Polymerase II Transcription Elongation	53	6.52e-06	-0.358000	3.26e-05
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	5.45e-06	-0.357000	2.79e-05
Chromosome Maintenance	86	9.99e-09	-0.357000	1.02e-07
Regulation of IFNG signaling	14	2.07e-02	-0.357000	3.57e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	1.60e-07	-0.357000	1.27e-06
Defective CFTR causes cystic fibrosis	59	2.09e-06	-0.357000	1.21e-05
Phospholipase C-mediated cascade; FGFR4	14	2.08e-02	-0.357000	3.57e-02
Nuclear events mediated by NFE2L2	76	7.47e-08	-0.357000	6.58e-07
Deactivation of the beta-catenin transactivating complex	39	1.17e-04	-0.356000	4.16e-04
Homologous DNA Pairing and Strand Exchange	41	7.86e-05	-0.356000	2.89e-04
Formation of the ternary complex, and subsequently, the 43S complex	47	2.42e-05	-0.356000	1.03e-04
Processing of DNA double-strand break ends	61	1.54e-06	-0.356000	9.28e-06
GABA synthesis, release, reuptake and degradation	19	7.27e-03	-0.356000	1.48e-02
Syndecan interactions	19	7.32e-03	-0.355000	1.49e-02
RORA activates gene expression	17	1.13e-02	-0.355000	2.13e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	1.15e-03	-0.355000	3.09e-03
Formation of the cornified envelope	74	1.31e-07	0.354000	1.06e-06
Transport of organic anions	10	5.22e-02	0.354000	7.67e-02
RNA polymerase II transcribes snRNA genes	77	7.92e-08	-0.354000	6.80e-07
G2/M Checkpoints	129	3.84e-12	-0.354000	6.38e-11
Regulation of PTEN stability and activity	66	6.67e-07	-0.354000	4.36e-06
Interactions of Vpr with host cellular proteins	33	4.39e-04	-0.353000	1.33e-03
RNA Polymerase I Transcription Termination	27	1.48e-03	-0.353000	3.77e-03
APC/C-mediated degradation of cell cycle proteins	86	1.47e-08	-0.353000	1.47e-07
Regulation of mitotic cell cycle	86	1.47e-08	-0.353000	1.47e-07
Signaling by ALK fusions and activated point mutants	51	1.30e-05	-0.353000	5.95e-05
Signaling by ALK in cancer	51	1.30e-05	-0.353000	5.95e-05
Digestion	21	5.13e-03	0.353000	1.10e-02
CaMK IV-mediated phosphorylation of CREB	10	5.36e-02	-0.352000	7.84e-02
Vpr-mediated nuclear import of PICs	32	5.60e-04	-0.352000	1.64e-03
RNA Polymerase II Pre-transcription Events	73	1.93e-07	-0.352000	1.47e-06
Regulation of TP53 Expression and Degradation	37	2.09e-04	-0.352000	6.96e-04
Major pathway of rRNA processing in the nucleolus and cytosol	171	1.96e-15	-0.352000	5.65e-14
Activation of gene expression by SREBF (SREBP)	42	8.02e-05	-0.351000	2.95e-04
Regulation of TP53 Activity through Association with Co-factors	14	2.30e-02	-0.351000	3.86e-02
Signaling by FGFR3 in disease	21	5.36e-03	-0.351000	1.14e-02
Signaling by NOTCH2	32	6.03e-04	-0.350000	1.76e-03
Beta-catenin independent WNT signaling	144	3.92e-13	-0.350000	7.49e-12
Autodegradation of Cdh1 by Cdh1:APC/C	62	1.88e-06	-0.350000	1.09e-05
UCH proteinases	81	5.16e-08	-0.350000	4.66e-07
Regulation of APC/C activators between G1/S and early anaphase	79	7.53e-08	-0.350000	6.58e-07
MECP2 regulates neuronal receptors and channels	17	1.26e-02	-0.349000	2.35e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	4.51e-02	-0.349000	6.80e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	1.14e-03	-0.349000	3.09e-03
Regulation of TP53 Degradation	36	2.91e-04	-0.349000	9.38e-04
CRMPs in Sema3A signaling	15	1.94e-02	-0.349000	3.36e-02
Signaling by WNT	263	1.79e-22	-0.349000	8.80e-21
G1/S-Specific Transcription	28	1.41e-03	-0.349000	3.62e-03
Initial triggering of complement	21	5.69e-03	0.348000	1.20e-02
Regulation of beta-cell development	41	1.16e-04	-0.348000	4.15e-04
Regulation of gene expression by Hypoxia-inducible Factor	11	4.59e-02	-0.348000	6.90e-02
Downstream signaling of activated FGFR2	29	1.20e-03	-0.347000	3.18e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	55	8.31e-06	-0.347000	4.07e-05
Recognition of DNA damage by PCNA-containing replication complex	29	1.20e-03	-0.347000	3.18e-03
Transcriptional Regulation by E2F6	32	6.73e-04	-0.347000	1.93e-03
tRNA processing	98	2.81e-09	-0.347000	3.13e-08
Ribosomal scanning and start codon recognition	54	1.02e-05	-0.347000	4.89e-05
Regulation of pyruvate dehydrogenase (PDH) complex	14	2.46e-02	-0.347000	4.05e-02
NIK–>noncanonical NF-kB signaling	57	5.96e-06	-0.346000	3.00e-05
Orc1 removal from chromatin	69	6.37e-07	-0.346000	4.18e-06
Telomere C-strand (Lagging Strand) Synthesis	32	7.00e-04	-0.346000	2.00e-03
Degradation of GLI1 by the proteasome	58	5.15e-06	-0.346000	2.66e-05
Ub-specific processing proteases	157	7.28e-14	-0.346000	1.66e-12
Degradation of GLI2 by the proteasome	58	5.25e-06	-0.346000	2.71e-05
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.90e-07	-0.345000	1.46e-06
Interleukin-15 signaling	13	3.11e-02	-0.345000	4.96e-02
SUMOylation of DNA methylation proteins	16	1.69e-02	-0.345000	2.99e-02
Base Excision Repair	45	6.44e-05	-0.344000	2.41e-04
Rev-mediated nuclear export of HIV RNA	33	6.22e-04	-0.344000	1.80e-03
BBSome-mediated cargo-targeting to cilium	23	4.28e-03	-0.344000	9.46e-03
Loss of Nlp from mitotic centrosomes	65	1.60e-06	-0.344000	9.54e-06
Loss of proteins required for interphase microtubule organization from the centrosome	65	1.60e-06	-0.344000	9.54e-06
Retrograde transport at the Trans-Golgi-Network	47	4.51e-05	-0.344000	1.81e-04
IRE1alpha activates chaperones	50	2.60e-05	-0.344000	1.10e-04
RUNX3 regulates NOTCH signaling	13	3.20e-02	-0.343000	5.09e-02
FRS-mediated FGFR4 signaling	21	6.44e-03	-0.343000	1.33e-02
STAT5 activation downstream of FLT3 ITD mutants	10	6.02e-02	-0.343000	8.66e-02
HS-GAG degradation	18	1.18e-02	-0.343000	2.22e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	1.61e-05	-0.342000	7.22e-05
mRNA Editing	10	6.13e-02	0.342000	8.79e-02
DNA Double-Strand Break Repair	130	1.70e-11	-0.341000	2.46e-10
Transcriptional Regulation by MECP2	60	4.84e-06	-0.341000	2.55e-05
Stabilization of p53	55	1.21e-05	-0.341000	5.60e-05
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	3.95e-07	-0.341000	2.72e-06
Energy dependent regulation of mTOR by LKB1-AMPK	28	1.81e-03	-0.341000	4.48e-03
Pexophagy	11	5.05e-02	-0.340000	7.45e-02
Regulation of TP53 Activity through Phosphorylation	88	3.31e-08	-0.340000	3.14e-07
SHC-mediated cascade:FGFR4	19	1.02e-02	-0.340000	1.95e-02
EPH-Ephrin signaling	90	2.38e-08	-0.340000	2.33e-07
PI-3K cascade:FGFR1	21	6.96e-03	-0.340000	1.42e-02
Export of Viral Ribonucleoproteins from Nucleus	31	1.06e-03	-0.340000	2.89e-03
AKT phosphorylates targets in the cytosol	14	2.77e-02	-0.340000	4.49e-02
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	3.44e-02	-0.339000	5.41e-02
Translation initiation complex formation	54	1.69e-05	-0.338000	7.49e-05
Mitotic Metaphase and Anaphase	222	3.66e-18	-0.338000	1.47e-16
Selenoamino acid metabolism	103	3.04e-09	-0.338000	3.37e-08
Signaling by FGFR2	72	7.06e-07	-0.338000	4.57e-06
SUMOylation of chromatin organization proteins	54	1.76e-05	-0.338000	7.69e-05
Phospholipase C-mediated cascade; FGFR3	12	4.29e-02	-0.338000	6.51e-02
mRNA Splicing - Major Pathway	173	1.80e-14	-0.337000	4.50e-13
TP53 Regulates Transcription of Death Receptors and Ligands	12	4.30e-02	-0.337000	6.53e-02
Telomere Extension By Telomerase	22	6.26e-03	-0.337000	1.30e-02
Regulation of FZD by ubiquitination	21	7.58e-03	-0.336000	1.53e-02
TICAM1, RIP1-mediated IKK complex recruitment	18	1.34e-02	-0.336000	2.49e-02
LDL clearance	19	1.13e-02	-0.336000	2.13e-02
CDK-mediated phosphorylation and removal of Cdc6	71	9.97e-07	-0.336000	6.24e-06
Anchoring of the basal body to the plasma membrane	92	2.60e-08	-0.335000	2.53e-07
Mitotic Anaphase	221	7.59e-18	-0.335000	2.90e-16
Ca2+ pathway	62	4.89e-06	-0.335000	2.55e-05
Deadenylation-dependent mRNA decay	56	1.41e-05	-0.335000	6.42e-05
AURKA Activation by TPX2	68	1.80e-06	-0.335000	1.05e-05
Extension of Telomeres	48	6.03e-05	-0.335000	2.30e-04
Cargo trafficking to the periciliary membrane	49	5.05e-05	-0.335000	1.98e-04
Mitotic Telophase/Cytokinesis	10	6.69e-02	-0.335000	9.48e-02
Metabolism of nitric oxide: NOS3 activation and regulation	15	2.49e-02	-0.334000	4.07e-02
Nucleotide Excision Repair	107	2.21e-09	-0.334000	2.54e-08
MyD88 cascade initiated on plasma membrane	79	2.74e-07	-0.334000	2.03e-06
Toll Like Receptor 10 (TLR10) Cascade	79	2.74e-07	-0.334000	2.03e-06
Toll Like Receptor 5 (TLR5) Cascade	79	2.74e-07	-0.334000	2.03e-06
Chromatin modifying enzymes	185	4.38e-15	-0.334000	1.19e-13
Chromatin organization	185	4.38e-15	-0.334000	1.19e-13
DNA Damage Bypass	46	9.07e-05	-0.333000	3.29e-04
rRNA processing in the nucleus and cytosol	180	1.15e-14	-0.333000	2.98e-13
Mitochondrial biogenesis	69	1.68e-06	-0.333000	9.93e-06
Diseases of signal transduction by growth factor receptors and second messengers	410	4.05e-31	-0.333000	2.95e-29
Resolution of Abasic Sites (AP sites)	37	4.59e-04	-0.333000	1.38e-03
HIV Life Cycle	139	1.22e-11	-0.333000	1.90e-10
Glucuronidation	25	4.02e-03	0.332000	8.97e-03
APC/C:Cdc20 mediated degradation of Securin	66	3.07e-06	-0.332000	1.71e-05
COPI-mediated anterograde transport	83	1.72e-07	-0.332000	1.34e-06
Nervous system development	527	4.68e-39	-0.332000	5.96e-37
Activation of BH3-only proteins	30	1.67e-03	-0.332000	4.17e-03
Respiratory electron transport	90	5.43e-08	-0.331000	4.85e-07
Signaling by TGF-beta Receptor Complex	86	1.09e-07	-0.331000	8.87e-07
Signaling by FGFR4 in disease	11	5.77e-02	-0.330000	8.34e-02
ESR-mediated signaling	160	5.30e-13	-0.330000	1.00e-11
RNA Polymerase II Transcription Termination	62	6.82e-06	-0.330000	3.39e-05
Activated NOTCH1 Transmits Signal to the Nucleus	31	1.46e-03	-0.330000	3.74e-03
MASTL Facilitates Mitotic Progression	10	7.06e-02	-0.330000	9.93e-02
SUMOylation of RNA binding proteins	45	1.27e-04	-0.330000	4.49e-04
SUMOylation of intracellular receptors	29	2.10e-03	-0.330000	5.14e-03
FRS-mediated FGFR3 signaling	19	1.28e-02	-0.330000	2.39e-02
Axon guidance	503	5.84e-37	-0.330000	5.95e-35
DNA Repair	277	3.17e-21	-0.329000	1.47e-19
Transcriptional regulation of white adipocyte differentiation	81	2.90e-07	-0.329000	2.10e-06
Host Interactions of HIV factors	122	3.38e-10	-0.329000	4.17e-09
Regulation of mRNA stability by proteins that bind AU-rich elements	87	1.18e-07	-0.328000	9.51e-07
PI-3K cascade:FGFR2	22	7.72e-03	-0.328000	1.54e-02
Degradation of DVL	55	2.58e-05	-0.328000	1.10e-04
Regulation of KIT signaling	16	2.34e-02	-0.327000	3.91e-02
mRNA Splicing	183	2.10e-14	-0.327000	5.09e-13
Formation of Incision Complex in GG-NER	40	3.43e-04	-0.327000	1.08e-03
COPI-dependent Golgi-to-ER retrograde traffic	81	3.56e-07	-0.327000	2.50e-06
Cytosolic sensors of pathogen-associated DNA	60	1.18e-05	-0.327000	5.53e-05
Negative regulation of NMDA receptor-mediated neuronal transmission	20	1.14e-02	-0.327000	2.16e-02
Protein methylation	16	2.37e-02	-0.327000	3.95e-02
Neddylation	228	1.75e-17	-0.326000	6.53e-16
DNA Replication Pre-Initiation	97	2.67e-08	-0.326000	2.58e-07
Interactions of Rev with host cellular proteins	35	8.32e-04	-0.326000	2.34e-03
FGFR4 ligand binding and activation	13	4.18e-02	-0.326000	6.38e-02
HIV Infection	216	1.40e-16	-0.326000	4.55e-15
rRNA processing	186	1.69e-14	-0.326000	4.32e-13
Glutamate and glutamine metabolism	12	5.11e-02	-0.325000	7.54e-02
SHC-mediated cascade:FGFR3	17	2.04e-02	-0.325000	3.52e-02
Constitutive Signaling by Overexpressed ERBB2	10	7.54e-02	-0.325000	1.05e-01
Hedgehog ‘on’ state	83	3.13e-07	-0.325000	2.25e-06
p75NTR signals via NF-kB	15	2.95e-02	-0.324000	4.74e-02
Assembly of the pre-replicative complex	82	3.73e-07	-0.324000	2.60e-06
Organelle biogenesis and maintenance	243	2.64e-18	-0.324000	1.09e-16
Metabolism of RNA	638	9.29e-45	-0.324000	1.42e-42
S Phase	157	2.26e-12	-0.324000	3.93e-11
Signaling by FGFR in disease	61	1.20e-05	-0.324000	5.58e-05
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	95	4.97e-08	-0.323000	4.52e-07
Epigenetic regulation of gene expression	83	3.46e-07	-0.323000	2.46e-06
G2/M Transition	176	1.27e-13	-0.323000	2.63e-12
NF-kB is activated and signals survival	12	5.25e-02	-0.323000	7.70e-02
Unwinding of DNA	12	5.25e-02	-0.323000	7.70e-02
Cell-extracellular matrix interactions	14	3.62e-02	-0.323000	5.64e-02
Mitotic G2-G2/M phases	178	9.61e-14	-0.323000	2.05e-12
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	5.26e-02	-0.323000	7.70e-02
Late Phase of HIV Life Cycle	126	3.72e-10	-0.323000	4.51e-09
Biotin transport and metabolism	10	7.72e-02	-0.323000	1.07e-01
Creation of C4 and C2 activators	14	3.68e-02	0.322000	5.71e-02
Regulation of TNFR1 signaling	32	1.62e-03	-0.322000	4.06e-03
Neurotransmitter release cycle	47	1.34e-04	-0.322000	4.68e-04
Aspirin ADME	44	2.20e-04	0.322000	7.32e-04
NEP/NS2 Interacts with the Cellular Export Machinery	30	2.30e-03	-0.321000	5.55e-03
Dectin-1 mediated noncanonical NF-kB signaling	60	1.64e-05	-0.321000	7.28e-05
MyD88 dependent cascade initiated on endosome	84	3.54e-07	-0.321000	2.49e-06
Toll Like Receptor 7/8 (TLR7/8) Cascade	84	3.54e-07	-0.321000	2.49e-06
Signaling by FLT3 ITD and TKD mutants	16	2.61e-02	-0.321000	4.25e-02
Toll Like Receptor 3 (TLR3) Cascade	88	1.90e-07	-0.321000	1.46e-06
SUMOylation of SUMOylation proteins	33	1.41e-03	-0.321000	3.62e-03
PERK regulates gene expression	32	1.68e-03	-0.321000	4.21e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	2.60e-06	-0.320000	1.48e-05
Regulation of PLK1 Activity at G2/M Transition	83	4.55e-07	-0.320000	3.12e-06
Regulation of PTEN gene transcription	59	2.10e-05	-0.320000	9.07e-05
Translesion synthesis by POLK	17	2.23e-02	-0.320000	3.79e-02
HATs acetylate histones	71	3.16e-06	-0.320000	1.75e-05
Cilium Assembly	174	3.51e-13	-0.319000	6.78e-12
Signaling by Erythropoietin	25	5.73e-03	-0.319000	1.20e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	2.71e-02	-0.319000	4.39e-02
VEGFR2 mediated cell proliferation	19	1.60e-02	-0.319000	2.86e-02
TNF signaling	40	4.78e-04	-0.319000	1.42e-03
RND3 GTPase cycle	41	4.13e-04	-0.319000	1.27e-03
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	94	9.37e-08	-0.318000	7.78e-07
Signaling by KIT in disease	20	1.37e-02	-0.318000	2.52e-02
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	1.37e-02	-0.318000	2.52e-02
PCNA-Dependent Long Patch Base Excision Repair	21	1.16e-02	-0.318000	2.19e-02
Cell Cycle, Mitotic	477	9.61e-33	-0.317000	7.34e-31
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	83	5.72e-07	-0.317000	3.80e-06
Purine salvage	12	5.70e-02	-0.317000	8.26e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	2.36e-02	-0.317000	3.94e-02
CLEC7A (Dectin-1) induces NFAT activation	11	6.88e-02	-0.317000	9.68e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	6.88e-02	-0.317000	9.68e-02
TNFR1-induced NFkappaB signaling pathway	22	1.02e-02	-0.316000	1.95e-02
Homology Directed Repair	100	4.66e-08	-0.316000	4.26e-07
Glutamate Neurotransmitter Release Cycle	23	8.79e-03	-0.315000	1.72e-02
M Phase	336	2.23e-23	-0.315000	1.17e-21
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	5.87e-02	-0.315000	8.47e-02
Transport of Ribonucleoproteins into the Host Nucleus	30	2.82e-03	-0.315000	6.56e-03
SUMOylation of DNA replication proteins	44	3.00e-04	-0.315000	9.60e-04
Interleukin-1 signaling	97	8.21e-08	-0.315000	7.01e-07
Unfolded Protein Response (UPR)	91	2.09e-07	-0.315000	1.59e-06
Transport of the SLBP Dependant Mature mRNA	34	1.51e-03	-0.314000	3.83e-03
Processing of Capped Intron-Containing Pre-mRNA	231	1.66e-16	-0.314000	5.28e-15
RHOV GTPase cycle	36	1.10e-03	-0.314000	2.99e-03
Sensory Perception	576	2.81e-38	0.314000	3.30e-36
DNA Replication	125	1.30e-09	-0.314000	1.52e-08
MAPK6/MAPK4 signaling	89	3.09e-07	-0.314000	2.23e-06
Transcriptional activation of mitochondrial biogenesis	51	1.06e-04	-0.314000	3.81e-04
FCERI mediated NF-kB activation	74	3.14e-06	-0.313000	1.75e-05
Transcription of E2F targets under negative control by DREAM complex	19	1.81e-02	-0.313000	3.17e-02
Regulation of TP53 Activity	154	1.90e-11	-0.313000	2.71e-10
Antigen processing: Ubiquitination & Proteasome degradation	293	2.74e-20	-0.313000	1.23e-18
Golgi Cisternae Pericentriolar Stack Reorganization	14	4.28e-02	-0.313000	6.51e-02
Transcriptional Regulation by TP53	346	1.30e-23	-0.313000	7.33e-22
E3 ubiquitin ligases ubiquitinate target proteins	43	3.88e-04	-0.313000	1.20e-03
ATF4 activates genes in response to endoplasmic reticulum stress	28	4.20e-03	-0.312000	9.32e-03
mRNA decay by 3’ to 5’ exoribonuclease	16	3.05e-02	-0.312000	4.89e-02
HCMV Early Events	55	6.17e-05	-0.312000	2.33e-04
Activation of NF-kappaB in B cells	64	1.57e-05	-0.312000	7.05e-05
Cross-presentation of soluble exogenous antigens (endosomes)	48	1.84e-04	-0.312000	6.20e-04
SUMO E3 ligases SUMOylate target proteins	158	1.27e-11	-0.312000	1.93e-10
FGFR2c ligand binding and activation	12	6.15e-02	-0.312000	8.80e-02
mRNA Splicing - Minor Pathway	53	8.58e-05	-0.312000	3.13e-04
Signaling by Leptin	11	7.35e-02	-0.312000	1.03e-01
SUMOylation of transcription cofactors	43	4.07e-04	-0.311000	1.25e-03
Hedgehog ‘off’ state	97	1.17e-07	-0.311000	9.50e-07
Deubiquitination	230	4.10e-16	-0.311000	1.28e-14
Erythropoietin activates RAS	14	4.41e-02	-0.311000	6.66e-02
DNA strand elongation	31	2.77e-03	-0.310000	6.46e-03
Protein ubiquitination	61	2.76e-05	-0.310000	1.16e-04
trans-Golgi Network Vesicle Budding	67	1.12e-05	-0.310000	5.27e-05
Switching of origins to a post-replicative state	90	3.78e-07	-0.310000	2.63e-06
Cellular response to starvation	147	8.90e-11	-0.309000	1.18e-09
VLDLR internalisation and degradation	16	3.20e-02	-0.309000	5.09e-02
MyD88-independent TLR4 cascade	92	2.85e-07	-0.309000	2.08e-06
TRIF(TICAM1)-mediated TLR4 signaling	92	2.85e-07	-0.309000	2.08e-06
Signalling to RAS	20	1.66e-02	-0.309000	2.94e-02
Constitutive Signaling by AKT1 E17K in Cancer	25	7.42e-03	-0.309000	1.51e-02
Signaling by FGFR	85	8.23e-07	-0.309000	5.22e-06
Complement cascade	56	6.37e-05	0.309000	2.39e-04
MET activates RAP1 and RAC1	11	7.61e-02	-0.309000	1.06e-01
Signaling by CSF3 (G-CSF)	28	4.69e-03	-0.309000	1.02e-02
Phase 0 - rapid depolarisation	31	2.94e-03	-0.309000	6.79e-03
Synthesis of substrates in N-glycan biosythesis	60	3.55e-05	-0.308000	1.47e-04
HDR through Homologous Recombination (HRR)	65	1.71e-05	-0.308000	7.55e-05
Dectin-2 family	28	4.77e-03	0.308000	1.03e-02
Regulation of Complement cascade	45	3.48e-04	0.308000	1.10e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	32	2.57e-03	-0.308000	6.06e-03
Complex I biogenesis	49	1.91e-04	-0.308000	6.41e-04
Signaling by ERBB2 ECD mutants	15	3.91e-02	-0.308000	6.02e-02
Miscellaneous transport and binding events	21	1.47e-02	-0.307000	2.66e-02
Adrenaline,noradrenaline inhibits insulin secretion	28	4.86e-03	-0.307000	1.05e-02
RHO GTPase Effectors	232	7.07e-16	-0.307000	2.08e-14
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	7.92e-03	-0.307000	1.57e-02
Cell Cycle	602	4.40e-38	-0.307000	4.80e-36
SUMOylation	164	1.24e-11	-0.306000	1.91e-10
Metabolism of non-coding RNA	50	1.82e-04	-0.306000	6.17e-04
snRNP Assembly	50	1.82e-04	-0.306000	6.17e-04
mRNA 3’-end processing	53	1.21e-04	-0.305000	4.30e-04
Retrograde neurotrophin signalling	14	4.83e-02	-0.305000	7.20e-02
p75NTR recruits signalling complexes	12	6.77e-02	-0.304000	9.57e-02
Signaling by TGFB family members	114	1.92e-08	-0.304000	1.89e-07
Protein folding	96	2.51e-07	-0.304000	1.88e-06
Intrinsic Pathway for Apoptosis	52	1.49e-04	-0.304000	5.15e-04
TICAM1-dependent activation of IRF3/IRF7	12	6.85e-02	-0.304000	9.66e-02
Dual Incision in GG-NER	39	1.05e-03	-0.303000	2.88e-03
Golgi Associated Vesicle Biogenesis	51	1.83e-04	-0.303000	6.19e-04
Termination of translesion DNA synthesis	31	3.58e-03	-0.302000	8.13e-03
Deposition of new CENPA-containing nucleosomes at the centromere	26	7.64e-03	-0.302000	1.53e-02
Nucleosome assembly	26	7.64e-03	-0.302000	1.53e-02
Lagging Strand Synthesis	19	2.26e-02	-0.302000	3.82e-02
Downstream signaling events of B Cell Receptor (BCR)	78	3.97e-06	-0.302000	2.18e-05
TBC/RABGAPs	42	7.21e-04	-0.301000	2.05e-03
Fertilization	26	7.80e-03	0.301000	1.56e-02
Chemokine receptors bind chemokines	56	9.58e-05	0.301000	3.46e-04
Chaperonin-mediated protein folding	90	7.80e-07	-0.301000	4.98e-06
cGMP effects	15	4.36e-02	-0.301000	6.60e-02
TGF-beta receptor signaling activates SMADs	45	4.77e-04	-0.301000	1.42e-03
Regulation of gene expression in beta cells	21	1.70e-02	-0.301000	3.00e-02
Synthesis of DNA	118	1.67e-08	-0.300000	1.66e-07
FRS-mediated FGFR1 signaling	23	1.28e-02	-0.300000	2.38e-02
Elevation of cytosolic Ca2+ levels	16	3.78e-02	-0.300000	5.85e-02
PINK1-PRKN Mediated Mitophagy	21	1.74e-02	-0.300000	3.06e-02
Transport of the SLBP independent Mature mRNA	33	2.87e-03	-0.300000	6.66e-03
Class I peroxisomal membrane protein import	19	2.37e-02	-0.300000	3.95e-02
Golgi-to-ER retrograde transport	115	2.78e-08	-0.300000	2.67e-07
FGFR3 mutant receptor activation	11	8.54e-02	-0.299000	1.18e-01
Signaling by activated point mutants of FGFR3	11	8.54e-02	-0.299000	1.18e-01
Ephrin signaling	17	3.27e-02	-0.299000	5.17e-02
Incretin synthesis, secretion, and inactivation	23	1.30e-02	-0.299000	2.41e-02
Apoptosis	164	3.63e-11	-0.299000	5.09e-10
Recruitment of NuMA to mitotic centrosomes	76	6.48e-06	-0.299000	3.26e-05
RHOC GTPase cycle	69	1.80e-05	-0.298000	7.85e-05
Uptake and actions of bacterial toxins	29	5.44e-03	-0.298000	1.15e-02
Intraflagellar transport	36	1.98e-03	-0.298000	4.86e-03
Elastic fibre formation	41	9.64e-04	-0.298000	2.67e-03
p75 NTR receptor-mediated signalling	89	1.21e-06	-0.297000	7.41e-06
RHO GTPases Activate WASPs and WAVEs	34	2.68e-03	-0.297000	6.29e-03
DNA Double Strand Break Response	42	8.51e-04	-0.297000	2.38e-03
Intra-Golgi and retrograde Golgi-to-ER traffic	181	5.69e-12	-0.296000	9.34e-11
Regulation of signaling by CBL	18	2.96e-02	-0.296000	4.75e-02
MTOR signalling	40	1.20e-03	-0.296000	3.17e-03
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	1.59e-03	-0.296000	4.03e-03
ATF6 (ATF6-alpha) activates chaperone genes	10	1.05e-01	-0.296000	1.40e-01
Downstream signaling of activated FGFR1	31	4.37e-03	-0.296000	9.58e-03
VxPx cargo-targeting to cilium	20	2.22e-02	-0.295000	3.78e-02
RAF activation	33	3.35e-03	-0.295000	7.67e-03
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	23	1.44e-02	-0.295000	2.62e-02
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	23	1.44e-02	-0.295000	2.62e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	23	1.44e-02	-0.295000	2.62e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	23	1.44e-02	-0.295000	2.62e-02
Impaired BRCA2 binding to PALB2	23	1.44e-02	-0.295000	2.62e-02
Apoptotic cleavage of cell adhesion proteins	11	9.08e-02	-0.294000	1.24e-01
Removal of the Flap Intermediate	13	6.64e-02	-0.294000	9.42e-02
tRNA modification in the nucleus and cytosol	38	1.71e-03	-0.294000	4.26e-03
Synaptic adhesion-like molecules	19	2.66e-02	-0.294000	4.32e-02
Heparan sulfate/heparin (HS-GAG) metabolism	49	3.80e-04	-0.293000	1.18e-03
Signaling by NTRK3 (TRKC)	17	3.63e-02	-0.293000	5.64e-02
Glycogen synthesis	15	4.93e-02	-0.293000	7.31e-02
Platelet calcium homeostasis	27	8.40e-03	-0.293000	1.65e-02
SHC-mediated cascade:FGFR1	21	2.01e-02	-0.293000	3.47e-02
Mitochondrial Fatty Acid Beta-Oxidation	35	2.71e-03	-0.293000	6.37e-03
Asparagine N-linked glycosylation	278	4.02e-17	-0.293000	1.46e-15
Phospholipase C-mediated cascade: FGFR1	16	4.27e-02	-0.293000	6.50e-02
Transport of Mature Transcript to Cytoplasm	76	1.02e-05	-0.293000	4.89e-05
Positive epigenetic regulation of rRNA expression	43	9.10e-04	-0.292000	2.54e-03
ATF6 (ATF6-alpha) activates chaperones	11	9.34e-02	-0.292000	1.27e-01
Signaling by PDGF	52	2.68e-04	-0.292000	8.78e-04
Global Genome Nucleotide Excision Repair (GG-NER)	81	5.83e-06	-0.291000	2.96e-05
Removal of the Flap Intermediate from the C-strand	17	3.77e-02	-0.291000	5.83e-02
Defective B4GALT7 causes EDS, progeroid type	17	3.77e-02	-0.291000	5.83e-02
Cyclin D associated events in G1	46	6.41e-04	-0.291000	1.85e-03
G1 Phase	46	6.41e-04	-0.291000	1.85e-03
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	41	1.27e-03	-0.291000	3.33e-03
RHOBTB1 GTPase cycle	22	1.82e-02	-0.291000	3.18e-02
MAP kinase activation	58	1.28e-04	-0.291000	4.52e-04
FRS-mediated FGFR2 signaling	24	1.37e-02	-0.290000	2.53e-02
Toll Like Receptor 9 (TLR9) Cascade	88	2.49e-06	-0.290000	1.42e-05
Signaling by NOTCH	183	1.26e-11	-0.290000	1.92e-10
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	42	1.15e-03	-0.290000	3.09e-03
Centrosome maturation	77	1.09e-05	-0.290000	5.16e-05
Recruitment of mitotic centrosome proteins and complexes	77	1.09e-05	-0.290000	5.16e-05
Potential therapeutics for SARS	83	5.09e-06	-0.289000	2.65e-05
FOXO-mediated transcription	65	5.42e-05	-0.289000	2.10e-04
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	3.50e-03	-0.289000	7.99e-03
ER to Golgi Anterograde Transport	134	7.20e-09	-0.289000	7.48e-08
RNA Polymerase I Transcription	47	5.99e-04	-0.289000	1.75e-03
IKK complex recruitment mediated by RIP1	22	1.89e-02	-0.289000	3.29e-02
Circadian Clock	69	3.27e-05	-0.289000	1.36e-04
Branched-chain amino acid catabolism	20	2.52e-02	-0.289000	4.13e-02
Voltage gated Potassium channels	42	1.22e-03	-0.288000	3.21e-03
Citric acid cycle (TCA cycle)	21	2.25e-02	-0.287000	3.82e-02
Presynaptic function of Kainate receptors	21	2.25e-02	-0.287000	3.82e-02
Nuclear import of Rev protein	32	4.93e-03	-0.287000	1.06e-02
Interleukin-7 signaling	21	2.28e-02	-0.287000	3.84e-02
Gene expression (Transcription)	1407	8.74e-74	-0.287000	6.68e-71
Activation of kainate receptors upon glutamate binding	29	7.54e-03	-0.287000	1.52e-02
Nonhomologous End-Joining (NHEJ)	32	5.03e-03	-0.286000	1.08e-02
Extra-nuclear estrogen signaling	73	2.35e-05	-0.286000	1.01e-04
Activation of RAC1	11	1.01e-01	-0.286000	1.35e-01
Signaling by FGFR1 in disease	37	2.65e-03	-0.285000	6.24e-03
Platelet homeostasis	85	5.35e-06	-0.285000	2.75e-05
Signaling by Hedgehog	133	1.32e-08	-0.285000	1.34e-07
FGFR1 mutant receptor activation	30	6.86e-03	-0.285000	1.41e-02
RNA Polymerase I Transcription Initiation	42	1.38e-03	-0.285000	3.57e-03
Translocation of ZAP-70 to Immunological synapse	17	4.22e-02	0.284000	6.44e-02
Mitotic Prophase	78	1.39e-05	-0.284000	6.35e-05
Fc epsilon receptor (FCERI) signaling	126	3.52e-08	-0.284000	3.32e-07
ER-Phagosome pathway	87	4.58e-06	-0.284000	2.45e-05
SARS-CoV-2 modulates autophagy	11	1.03e-01	-0.284000	1.37e-01
RNA Polymerase II Transcription	1271	6.47e-66	-0.284000	2.47e-63
KEAP1-NFE2L2 pathway	103	6.31e-07	-0.284000	4.15e-06
Diseases of mitotic cell cycle	37	2.82e-03	-0.284000	6.56e-03
Reversible hydration of carbon dioxide	11	1.04e-01	-0.283000	1.38e-01
SHC-mediated cascade:FGFR2	22	2.15e-02	-0.283000	3.68e-02
RND2 GTPase cycle	42	1.50e-03	-0.283000	3.82e-03
Reduction of cytosolic Ca++ levels	11	1.04e-01	-0.283000	1.38e-01
Generic Transcription Pathway	1150	1.50e-59	-0.283000	2.86e-57
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	38	2.56e-03	-0.283000	6.06e-03
Death Receptor Signalling	129	2.89e-08	-0.283000	2.76e-07
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	3.34e-03	-0.282000	7.67e-03
Nuclear Pore Complex (NPC) Disassembly	34	4.36e-03	-0.282000	9.58e-03
Signaling by NOTCH3	48	7.08e-04	-0.282000	2.02e-03
Deadenylation of mRNA	25	1.46e-02	-0.282000	2.64e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	7.48e-03	-0.282000	1.51e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	7.48e-03	-0.282000	1.51e-02
The citric acid (TCA) cycle and respiratory electron transport	143	5.62e-09	-0.282000	5.96e-08
FGFR3 ligand binding and activation	12	9.09e-02	-0.282000	1.24e-01
FGFR3c ligand binding and activation	12	9.09e-02	-0.282000	1.24e-01
Eicosanoids	12	9.12e-02	0.282000	1.24e-01
SUMOylation of DNA damage response and repair proteins	71	4.05e-05	-0.282000	1.66e-04
Protein localization	147	3.78e-09	-0.281000	4.12e-08
Rap1 signalling	16	5.17e-02	-0.281000	7.60e-02
Kinesins	42	1.65e-03	-0.281000	4.13e-03
Cytoprotection by HMOX1	58	2.21e-04	-0.280000	7.33e-04
Phospholipase C-mediated cascade; FGFR2	17	4.58e-02	-0.280000	6.89e-02
Signaling by VEGF	101	1.18e-06	-0.280000	7.29e-06
SARS-CoV-2 modulates host translation machinery	46	1.03e-03	-0.279000	2.84e-03
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	1.09e-01	-0.279000	1.43e-01
RNA Polymerase I Promoter Clearance	46	1.06e-03	-0.279000	2.88e-03
Apoptotic factor-mediated response	17	4.64e-02	-0.279000	6.97e-02
WNT ligand biogenesis and trafficking	25	1.57e-02	-0.279000	2.82e-02
Meiotic recombination	26	1.38e-02	-0.279000	2.54e-02
Cellular Senescence	130	3.95e-08	-0.279000	3.70e-07
Signaling by FGFR4	40	2.28e-03	-0.279000	5.51e-03
Defective B3GAT3 causes JDSSDHD	17	4.67e-02	-0.279000	6.99e-02
Cellular responses to stress	683	1.21e-35	-0.278000	1.15e-33
Signaling by Hippo	19	3.55e-02	-0.278000	5.56e-02
ADP signalling through P2Y purinoceptor 12	22	2.38e-02	-0.278000	3.96e-02
ISG15 antiviral mechanism	71	4.98e-05	-0.278000	1.96e-04
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	20	3.12e-02	-0.278000	4.98e-02
Zinc transporters	17	4.72e-02	-0.278000	7.06e-02
FLT3 Signaling	38	3.03e-03	-0.278000	7.00e-03
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	4.14e-02	-0.278000	6.33e-02
Unblocking of NMDA receptors, glutamate binding and activation	19	3.62e-02	-0.277000	5.64e-02
Senescence-Associated Secretory Phenotype (SASP)	53	4.72e-04	-0.277000	1.41e-03
Processing and activation of SUMO	10	1.29e-01	-0.277000	1.65e-01
Sensory processing of sound by inner hair cells of the cochlea	62	1.68e-04	-0.276000	5.78e-04
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	1.92e-02	-0.276000	3.33e-02
DAG and IP3 signaling	39	2.85e-03	-0.276000	6.63e-03
TP53 Regulates Metabolic Genes	83	1.51e-05	-0.275000	6.81e-05
G beta:gamma signalling through PLC beta	20	3.36e-02	-0.274000	5.30e-02
Killing mechanisms	11	1.15e-01	-0.274000	1.50e-01
WNT5:FZD7-mediated leishmania damping	11	1.15e-01	-0.274000	1.50e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	1.15e-01	-0.274000	1.50e-01
Signaling by Receptor Tyrosine Kinases	492	1.67e-25	-0.274000	1.02e-23
Cellular responses to stimuli	697	3.62e-35	-0.274000	3.25e-33
Pentose phosphate pathway	12	1.01e-01	-0.273000	1.35e-01
Antiviral mechanism by IFN-stimulated genes	78	3.02e-05	-0.273000	1.27e-04
G beta:gamma signalling through BTK	17	5.17e-02	-0.272000	7.60e-02
Nucleotide biosynthesis	14	7.74e-02	-0.272000	1.08e-01
Opioid Signalling	88	1.03e-05	-0.272000	4.91e-05
Calnexin/calreticulin cycle	25	1.86e-02	-0.272000	3.24e-02
Nitric oxide stimulates guanylate cyclase	22	2.73e-02	-0.272000	4.42e-02
Glycosphingolipid metabolism	40	2.93e-03	-0.272000	6.79e-03
Erythrocytes take up carbon dioxide and release oxygen	12	1.03e-01	-0.272000	1.38e-01
O2/CO2 exchange in erythrocytes	12	1.03e-01	-0.272000	1.38e-01
Oncogenic MAPK signaling	76	4.22e-05	-0.272000	1.71e-04
Calcitonin-like ligand receptors	10	1.37e-01	-0.272000	1.74e-01
Activation of NMDA receptors and postsynaptic events	69	9.71e-05	-0.271000	3.50e-04
Activation of the pre-replicative complex	31	8.99e-03	-0.271000	1.76e-02
Assembly and cell surface presentation of NMDA receptors	23	2.47e-02	-0.271000	4.05e-02
NCAM1 interactions	36	4.98e-03	-0.270000	1.07e-02
Zinc influx into cells by the SLC39 gene family	10	1.39e-01	-0.270000	1.76e-01
MAPK1/MAPK3 signaling	271	1.91e-14	-0.270000	4.71e-13
ER Quality Control Compartment (ERQC)	20	3.69e-02	-0.269000	5.72e-02
Selective autophagy	59	3.42e-04	-0.269000	1.08e-03
Regulation of MECP2 expression and activity	30	1.06e-02	-0.269000	2.02e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	8.11e-02	-0.269000	1.12e-01
VEGFA-VEGFR2 Pathway	93	7.38e-06	-0.269000	3.64e-05
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	604	1.02e-29	-0.269000	7.08e-28
Presynaptic nicotinic acetylcholine receptors	12	1.07e-01	0.269000	1.41e-01
Activation of Matrix Metalloproteinases	31	9.66e-03	0.268000	1.86e-02
Downregulation of TGF-beta receptor signaling	26	1.79e-02	-0.268000	3.13e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	8.28e-02	-0.268000	1.15e-01
Ras activation upon Ca2+ influx through NMDA receptor	19	4.37e-02	-0.267000	6.62e-02
Class I MHC mediated antigen processing & presentation	363	2.03e-18	-0.267000	8.60e-17
Oxidative Stress Induced Senescence	66	1.78e-04	-0.267000	6.06e-04
RAF/MAP kinase cascade	265	7.71e-14	-0.266000	1.73e-12
CTLA4 inhibitory signaling	21	3.49e-02	-0.266000	5.46e-02
FGFR1c ligand binding and activation	11	1.27e-01	-0.266000	1.63e-01
Signaling by activated point mutants of FGFR1	11	1.27e-01	-0.266000	1.63e-01
Iron uptake and transport	57	5.22e-04	-0.266000	1.54e-03
MAPK family signaling cascades	312	6.67e-16	-0.265000	2.00e-14
ALK mutants bind TKIs	12	1.11e-01	-0.265000	1.46e-01
Cargo recognition for clathrin-mediated endocytosis	98	5.74e-06	-0.265000	2.93e-05
Clathrin-mediated endocytosis	135	1.05e-07	-0.265000	8.60e-07
Gluconeogenesis	32	9.50e-03	-0.265000	1.84e-02
Protein-protein interactions at synapses	78	5.22e-05	-0.265000	2.03e-04
Negative regulators of DDX58/IFIH1 signaling	34	7.53e-03	-0.265000	1.52e-02
HCMV Infection	79	4.71e-05	-0.265000	1.87e-04
Metabolism of proteins	1774	4.57e-78	-0.265000	6.98e-75
Signaling by Rho GTPases	590	3.17e-28	-0.265000	2.11e-26
FCERI mediated MAPK activation	29	1.37e-02	-0.264000	2.52e-02
Maturation of nucleoprotein	11	1.30e-01	-0.264000	1.66e-01
Signaling by FGFR3	39	4.33e-03	-0.264000	9.55e-03
Cell death signalling via NRAGE, NRIF and NADE	69	1.52e-04	-0.264000	5.24e-04
RHOBTB GTPase Cycle	34	7.85e-03	-0.263000	1.56e-02
Inactivation of CSF3 (G-CSF) signaling	23	2.88e-02	-0.263000	4.63e-02
Receptor Mediated Mitophagy	10	1.49e-01	-0.263000	1.87e-01
CD28 dependent PI3K/Akt signaling	22	3.25e-02	-0.263000	5.16e-02
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	1.80e-02	-0.263000	3.16e-02
Synthesis of IP3 and IP4 in the cytosol	25	2.31e-02	-0.262000	3.87e-02
Metal ion SLC transporters	25	2.32e-02	-0.262000	3.89e-02
Intra-Golgi traffic	43	2.93e-03	-0.262000	6.79e-03
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	14	8.95e-02	0.262000	1.22e-01
Diseases of hemostasis	14	8.95e-02	0.262000	1.22e-01
VEGFR2 mediated vascular permeability	26	2.07e-02	-0.262000	3.57e-02
Interleukin-10 signaling	45	2.36e-03	0.262000	5.68e-03
Mismatch Repair	15	7.92e-02	-0.262000	1.10e-01
FGFR1 ligand binding and activation	15	7.93e-02	-0.262000	1.10e-01
Translesion Synthesis by POLH	19	4.84e-02	-0.262000	7.21e-02
Transport to the Golgi and subsequent modification	165	6.56e-09	-0.261000	6.87e-08
Neurexins and neuroligins	52	1.10e-03	-0.261000	2.99e-03
NS1 Mediated Effects on Host Pathways	39	4.75e-03	-0.261000	1.03e-02
CaM pathway	33	9.46e-03	-0.261000	1.84e-02
Calmodulin induced events	33	9.46e-03	-0.261000	1.84e-02
DSCAM interactions	11	1.34e-01	-0.261000	1.70e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	6.26e-02	-0.261000	8.94e-02
RHO GTPases Activate ROCKs	19	4.91e-02	-0.261000	7.29e-02
Glycogen breakdown (glycogenolysis)	12	1.18e-01	-0.260000	1.53e-01
Defective GALNT3 causes HFTC	18	5.58e-02	0.260000	8.10e-02
Meiosis	56	7.66e-04	-0.260000	2.16e-03
Nuclear Envelope (NE) Reassembly	73	1.25e-04	-0.260000	4.43e-04
G alpha (z) signalling events	48	1.87e-03	-0.259000	4.62e-03
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	11	1.38e-01	0.259000	1.74e-01
Mitophagy	27	2.00e-02	-0.258000	3.46e-02
Phosphorylation of CD3 and TCR zeta chains	20	4.56e-02	0.258000	6.88e-02
Effects of PIP2 hydrolysis	26	2.27e-02	-0.258000	3.83e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	6.60e-03	-0.258000	1.36e-02
Toll Like Receptor 4 (TLR4) Cascade	124	7.06e-07	-0.258000	4.57e-06
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	6.60e-02	-0.257000	9.39e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	2.58e-02	-0.257000	4.21e-02
Nuclear Envelope Breakdown	50	1.63e-03	-0.257000	4.09e-03
SUMOylation of ubiquitinylation proteins	37	6.75e-03	-0.257000	1.39e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	6.63e-02	-0.257000	9.40e-02
Nuclear Receptor transcription pathway	51	1.53e-03	-0.256000	3.88e-03
WNT5A-dependent internalization of FZD4	15	8.56e-02	-0.256000	1.18e-01
Molecules associated with elastic fibres	30	1.51e-02	-0.256000	2.73e-02
Membrane Trafficking	586	2.16e-26	-0.256000	1.38e-24
CLEC7A (Dectin-1) signaling	96	1.46e-05	-0.256000	6.63e-05
Acetylcholine binding and downstream events	14	9.86e-02	0.255000	1.33e-01
Postsynaptic nicotinic acetylcholine receptors	14	9.86e-02	0.255000	1.33e-01
Listeria monocytogenes entry into host cells	19	5.44e-02	-0.255000	7.94e-02
Signaling by SCF-KIT	43	3.83e-03	-0.255000	8.63e-03
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	9.95e-02	-0.254000	1.34e-01
Apoptotic execution phase	43	3.91e-03	-0.254000	8.76e-03
Signaling by Nuclear Receptors	237	1.57e-11	-0.254000	2.33e-10
Sensory processing of sound by outer hair cells of the cochlea	49	2.11e-03	-0.254000	5.16e-03
Activation of BAD and translocation to mitochondria	15	8.88e-02	-0.254000	1.21e-01
Transcriptional regulation by RUNX1	183	3.09e-09	-0.254000	3.40e-08
Apoptotic cleavage of cellular proteins	35	9.46e-03	-0.253000	1.84e-02
Defective GALNT12 causes CRCS1	18	6.31e-02	0.253000	8.99e-02
RHOF GTPase cycle	40	5.74e-03	-0.252000	1.20e-02
Ethanol oxidation	12	1.31e-01	0.252000	1.67e-01
Signaling by FGFR1	49	2.30e-03	-0.252000	5.55e-03
Glucose metabolism	87	5.08e-05	-0.251000	1.99e-04
PECAM1 interactions	12	1.32e-01	-0.251000	1.68e-01
ABC transporter disorders	75	1.69e-04	-0.251000	5.80e-04
DNA Damage Recognition in GG-NER	36	9.13e-03	-0.251000	1.78e-02
Recycling of bile acids and salts	18	6.54e-02	0.251000	9.31e-02
Inactivation of APC/C via direct inhibition of the APC/C complex	21	4.67e-02	-0.251000	6.99e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	4.67e-02	-0.251000	6.99e-02
Glycolysis	68	3.49e-04	-0.251000	1.10e-03
Post NMDA receptor activation events	58	9.70e-04	-0.250000	2.68e-03
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	9.37e-02	-0.250000	1.27e-01
Activated point mutants of FGFR2	16	8.34e-02	-0.250000	1.15e-01
G beta:gamma signalling through CDC42	19	5.96e-02	-0.250000	8.58e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	9.50e-02	-0.249000	1.28e-01
Interleukin-17 signaling	66	4.71e-04	-0.249000	1.41e-03
Sensory processing of sound	69	3.63e-04	-0.248000	1.14e-03
Downregulation of ERBB2:ERBB3 signaling	13	1.21e-01	-0.248000	1.57e-01
Processive synthesis on the C-strand of the telomere	19	6.13e-02	-0.248000	8.79e-02
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	12	1.38e-01	-0.248000	1.74e-01
Assembly Of The HIV Virion	16	8.65e-02	-0.247000	1.19e-01
PKMTs methylate histone lysines	37	9.20e-03	-0.247000	1.79e-02
Cellular response to chemical stress	187	5.38e-09	-0.247000	5.75e-08
Adenylate cyclase inhibitory pathway	14	1.09e-01	-0.247000	1.44e-01
Laminin interactions	23	4.07e-02	-0.246000	6.24e-02
Heme signaling	45	4.21e-03	-0.246000	9.32e-03
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	1.24e-01	-0.246000	1.60e-01
Cholesterol biosynthesis	24	3.66e-02	-0.246000	5.69e-02
Ca-dependent events	35	1.16e-02	-0.246000	2.19e-02
Lysosome Vesicle Biogenesis	33	1.43e-02	-0.246000	2.61e-02
Post-translational protein modification	1294	4.16e-50	-0.244000	7.06e-48
Intracellular signaling by second messengers	313	9.70e-14	-0.244000	2.05e-12
Disease	1624	1.44e-61	-0.244000	3.65e-59
Infectious disease	885	3.94e-35	-0.244000	3.34e-33
Signalling to ERKs	34	1.40e-02	-0.243000	2.56e-02
Activation of GABAB receptors	43	5.78e-03	-0.243000	1.21e-02
GABA B receptor activation	43	5.78e-03	-0.243000	1.21e-02
Dermatan sulfate biosynthesis	10	1.83e-01	-0.243000	2.25e-01
Constitutive Signaling by EGFRvIII	15	1.03e-01	-0.243000	1.38e-01
Signaling by EGFRvIII in Cancer	15	1.03e-01	-0.243000	1.38e-01
RHOU GTPase cycle	37	1.06e-02	-0.243000	2.02e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript	67	5.89e-04	-0.243000	1.72e-03
Synthesis, secretion, and deacylation of Ghrelin	19	6.72e-02	-0.242000	9.51e-02
A tetrasaccharide linker sequence is required for GAG synthesis	23	4.47e-02	-0.242000	6.75e-02
Prostacyclin signalling through prostacyclin receptor	19	6.81e-02	-0.242000	9.62e-02
Non-integrin membrane-ECM interactions	40	8.17e-03	-0.242000	1.61e-02
FCGR3A-mediated phagocytosis	57	1.61e-03	-0.241000	4.05e-03
Leishmania phagocytosis	57	1.61e-03	-0.241000	4.05e-03
Parasite infection	57	1.61e-03	-0.241000	4.05e-03
Other interleukin signaling	24	4.06e-02	-0.241000	6.24e-02
Activation of G protein gated Potassium channels	29	2.46e-02	-0.241000	4.05e-02
G protein gated Potassium channels	29	2.46e-02	-0.241000	4.05e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	29	2.46e-02	-0.241000	4.05e-02
Synthesis of PC	27	3.04e-02	-0.241000	4.87e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	94	5.47e-05	-0.241000	2.10e-04
Toll Like Receptor 2 (TLR2) Cascade	94	5.47e-05	-0.241000	2.10e-04
Toll Like Receptor TLR1:TLR2 Cascade	94	5.47e-05	-0.241000	2.10e-04
Toll Like Receptor TLR6:TLR2 Cascade	94	5.47e-05	-0.241000	2.10e-04
HCMV Late Events	54	2.24e-03	-0.240000	5.44e-03
ABC-family proteins mediated transport	98	3.95e-05	-0.240000	1.62e-04
Mitochondrial calcium ion transport	22	5.13e-02	-0.240000	7.56e-02
Programmed Cell Death	192	9.76e-09	-0.240000	1.00e-07
Ovarian tumor domain proteases	36	1.32e-02	-0.239000	2.44e-02
Potassium Channels	102	3.07e-05	-0.239000	1.28e-04
Long-term potentiation	22	5.26e-02	-0.239000	7.70e-02
Regulation of PTEN mRNA translation	25	3.89e-02	0.239000	6.00e-02
Signaling by cytosolic FGFR1 fusion mutants	17	8.87e-02	-0.238000	1.21e-01
GPER1 signaling	44	6.28e-03	-0.238000	1.30e-02
RHOJ GTPase cycle	51	3.27e-03	-0.238000	7.52e-03
RHO GTPases activate PKNs	34	1.63e-02	-0.238000	2.90e-02
PIP3 activates AKT signaling	275	1.06e-11	-0.238000	1.66e-10
Resolution of D-loop Structures through Holliday Junction Intermediates	31	2.27e-02	-0.236000	3.83e-02
PI3K/AKT Signaling in Cancer	103	3.42e-05	-0.236000	1.42e-04
TP53 Regulates Transcription of Cell Death Genes	42	8.17e-03	-0.236000	1.61e-02
Signaling by Non-Receptor Tyrosine Kinases	55	2.49e-03	-0.236000	5.93e-03
Signaling by PTK6	55	2.49e-03	-0.236000	5.93e-03
Resolution of D-Loop Structures	32	2.13e-02	-0.235000	3.64e-02
RHO GTPase cycle	421	1.09e-16	-0.235000	3.61e-15
IGF1R signaling cascade	51	3.69e-03	-0.235000	8.37e-03
Netrin-1 signaling	49	4.45e-03	-0.235000	9.73e-03
Cellular response to heat stress	95	7.70e-05	-0.235000	2.84e-04
Signaling by FLT3 fusion proteins	19	7.68e-02	-0.234000	1.07e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	104	3.59e-05	-0.234000	1.48e-04
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	16	1.06e-01	-0.233000	1.40e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	2.01e-01	-0.233000	2.45e-01
Vesicle-mediated transport	624	1.87e-23	-0.233000	1.02e-21
CD28 co-stimulation	32	2.24e-02	-0.233000	3.80e-02
Synthesis of PIPs at the plasma membrane	48	5.20e-03	-0.233000	1.11e-02
Meiotic synapsis	32	2.26e-02	-0.233000	3.82e-02
Signaling by the B Cell Receptor (BCR)	105	3.78e-05	-0.233000	1.55e-04
COPI-independent Golgi-to-ER retrograde traffic	34	1.89e-02	-0.233000	3.29e-02
InlB-mediated entry of Listeria monocytogenes into host cell	14	1.32e-01	-0.232000	1.68e-01
NOTCH3 Intracellular Domain Regulates Transcription	24	4.88e-02	-0.232000	7.25e-02
RHOB GTPase cycle	66	1.11e-03	-0.232000	3.00e-03
Josephin domain DUBs	11	1.83e-01	-0.232000	2.25e-01
Glycogen metabolism	24	4.94e-02	-0.232000	7.31e-02
Common Pathway of Fibrin Clot Formation	21	6.61e-02	0.232000	9.40e-02
Insulin receptor signalling cascade	53	3.53e-03	-0.232000	8.04e-03
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	52	3.86e-03	-0.231000	8.68e-03
Peroxisomal lipid metabolism	28	3.40e-02	-0.231000	5.36e-02
Cytochrome c-mediated apoptotic response	12	1.65e-01	-0.231000	2.05e-01
PTEN Regulation	150	1.01e-06	-0.231000	6.31e-06
Regulation of HSF1-mediated heat shock response	78	4.32e-04	-0.230000	1.32e-03
Interleukin-1 family signaling	134	4.09e-06	-0.230000	2.23e-05
Negative regulation of the PI3K/AKT network	111	2.74e-05	-0.230000	1.16e-04
Response of Mtb to phagocytosis	22	6.17e-02	-0.230000	8.83e-02
Downstream TCR signaling	92	1.37e-04	-0.230000	4.75e-04
Prolonged ERK activation events	14	1.37e-01	-0.230000	1.73e-01
Formation of tubulin folding intermediates by CCT/TriC	26	4.29e-02	-0.229000	6.51e-02
Processing of SMDT1	15	1.25e-01	-0.229000	1.60e-01
MyD88 deficiency (TLR2/4)	16	1.13e-01	0.229000	1.48e-01
G-protein mediated events	52	4.33e-03	-0.229000	9.55e-03
FCERI mediated Ca+2 mobilization	27	3.98e-02	-0.228000	6.12e-02
RHOD GTPase cycle	49	5.69e-03	-0.228000	1.20e-02
Sialic acid metabolism	33	2.38e-02	-0.227000	3.96e-02
Receptor-type tyrosine-protein phosphatases	16	1.17e-01	-0.226000	1.52e-01
PI3K Cascade	43	1.02e-02	-0.226000	1.95e-02
G beta:gamma signalling through PI3Kgamma	25	5.01e-02	-0.226000	7.40e-02
Interleukin-2 signaling	11	1.95e-01	-0.225000	2.38e-01
Negative regulation of FGFR4 signaling	30	3.26e-02	-0.225000	5.17e-02
SARS-CoV Infections	339	1.06e-12	-0.225000	1.95e-11
Translation of Structural Proteins	29	3.62e-02	-0.225000	5.64e-02
NCAM signaling for neurite out-growth	57	3.49e-03	-0.224000	7.97e-03
IRS-related events triggered by IGF1R	50	6.26e-03	-0.223000	1.30e-02
DCC mediated attractive signaling	14	1.48e-01	-0.223000	1.86e-01
MET activates RAS signaling	11	2.01e-01	-0.223000	2.44e-01
Heme degradation	16	1.25e-01	0.222000	1.60e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	5.52e-02	-0.221000	8.03e-02
Signal Transduction	2408	2.26e-72	-0.221000	1.15e-69
Sema4D in semaphorin signaling	24	6.03e-02	-0.221000	8.67e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	23	6.62e-02	-0.221000	9.40e-02
Defective C1GALT1C1 causes TNPS	18	1.04e-01	0.221000	1.38e-01
Frs2-mediated activation	12	1.85e-01	-0.221000	2.27e-01
G-protein beta:gamma signalling	30	3.63e-02	-0.221000	5.64e-02
Signaling by ERBB2 KD Mutants	24	6.13e-02	-0.221000	8.79e-02
Sema4D induced cell migration and growth-cone collapse	20	8.86e-02	-0.220000	1.21e-01
IRS-mediated signalling	47	9.57e-03	-0.218000	1.85e-02
L1CAM interactions	92	3.01e-04	-0.218000	9.64e-04
COPII-mediated vesicle transport	66	2.20e-03	-0.218000	5.36e-03
Metabolism of amino acids and derivatives	345	3.30e-12	-0.218000	5.54e-11
APC-Cdc20 mediated degradation of Nek2A	26	5.46e-02	-0.218000	7.96e-02
Class B/2 (Secretin family receptors)	94	2.65e-04	-0.218000	8.70e-04
Rab regulation of trafficking	114	5.99e-05	-0.217000	2.29e-04
Fcgamma receptor (FCGR) dependent phagocytosis	82	6.73e-04	-0.217000	1.93e-03
Regulation of lipid metabolism by PPARalpha	116	5.31e-05	-0.217000	2.06e-04
RHOA GTPase cycle	140	9.35e-06	-0.217000	4.55e-05
Signal amplification	33	3.13e-02	-0.217000	4.99e-02
PKA activation	18	1.12e-01	-0.216000	1.46e-01
Neuronal System	371	7.25e-13	-0.216000	1.35e-11
RHOH GTPase cycle	36	2.46e-02	-0.216000	4.05e-02
Regulation of TLR by endogenous ligand	17	1.23e-01	0.216000	1.59e-01
Processive synthesis on the lagging strand	14	1.62e-01	-0.216000	2.02e-01
Inwardly rectifying K+ channels	35	2.73e-02	-0.216000	4.42e-02
Transferrin endocytosis and recycling	30	4.11e-02	-0.215000	6.29e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	9.66e-02	-0.215000	1.30e-01
Nuclear events stimulated by ALK signaling in cancer	18	1.15e-01	-0.214000	1.50e-01
Infection with Mycobacterium tuberculosis	26	5.93e-02	-0.214000	8.54e-02
PPARA activates gene expression	114	8.08e-05	-0.214000	2.96e-04
Signaling by EGFR	49	9.78e-03	-0.213000	1.88e-02
Sphingolipid metabolism	81	9.03e-04	-0.213000	2.52e-03
Cardiac conduction	120	5.58e-05	-0.213000	2.14e-04
Negative regulation of FLT3	15	1.54e-01	-0.213000	1.92e-01
Signaling by ERBB2	49	1.01e-02	-0.212000	1.93e-02
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	2.17e-02	0.212000	3.71e-02
Chondroitin sulfate/dermatan sulfate metabolism	45	1.38e-02	-0.212000	2.53e-02
Signaling by Insulin receptor	76	1.37e-03	-0.212000	3.55e-03
Pyruvate metabolism and Citric Acid (TCA) cycle	52	8.14e-03	-0.212000	1.61e-02
Plasma lipoprotein clearance	37	2.57e-02	-0.212000	4.20e-02
TNFR2 non-canonical NF-kB pathway	94	3.85e-04	-0.212000	1.19e-03
SARS-CoV-2 Infection	265	2.81e-09	-0.212000	3.13e-08
Toll-like Receptor Cascades	143	1.22e-05	-0.212000	5.63e-05
Inositol phosphate metabolism	45	1.41e-02	-0.211000	2.58e-02
RHO GTPases activate KTN1	11	2.25e-01	-0.211000	2.71e-01
Insulin processing	26	6.24e-02	-0.211000	8.92e-02
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	6.84e-02	-0.211000	9.64e-02
Signaling by Retinoic Acid	41	1.99e-02	-0.210000	3.44e-02
Ketone body metabolism	10	2.50e-01	-0.210000	2.98e-01
Interleukin receptor SHC signaling	24	7.49e-02	-0.210000	1.05e-01
Notch-HLH transcription pathway	24	7.50e-02	-0.210000	1.05e-01
FLT3 signaling in disease	28	5.48e-02	-0.210000	7.98e-02
Antigen processing-Cross presentation	102	2.58e-04	-0.209000	8.49e-04
Interleukin-6 family signaling	24	7.65e-02	-0.209000	1.07e-01
Membrane binding and targetting of GAG proteins	14	1.77e-01	-0.208000	2.19e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	1.77e-01	-0.208000	2.19e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	10	2.54e-01	-0.208000	3.03e-01
Negative regulation of FGFR3 signaling	28	5.71e-02	-0.208000	8.27e-02
Fatty acyl-CoA biosynthesis	35	3.40e-02	-0.207000	5.36e-02
Peroxisomal protein import	62	4.80e-03	-0.207000	1.04e-02
Signaling by BMP	27	6.30e-02	-0.207000	8.99e-02
Gene Silencing by RNA	80	1.40e-03	-0.206000	3.61e-03
DAP12 signaling	28	5.92e-02	-0.206000	8.54e-02
Regulation of TP53 Activity through Acetylation	29	5.58e-02	-0.205000	8.10e-02
Signaling by ERBB2 in Cancer	25	7.59e-02	-0.205000	1.06e-01
Constitutive Signaling by Aberrant PI3K in Cancer	77	1.95e-03	-0.204000	4.80e-03
NRAGE signals death through JNK	53	1.02e-02	-0.204000	1.95e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	2.47e-02	-0.203000	4.05e-02
RHOBTB2 GTPase cycle	22	9.99e-02	-0.203000	1.34e-01
SARS-CoV-1 Infection	51	1.23e-02	-0.202000	2.31e-02
mTORC1-mediated signalling	23	9.43e-02	-0.201000	1.27e-01
Regulation of actin dynamics for phagocytic cup formation	59	7.41e-03	-0.201000	1.51e-02
Negative regulation of FGFR1 signaling	32	4.85e-02	-0.201000	7.22e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	1.29e-01	-0.201000	1.65e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	1.29e-01	-0.201000	1.65e-01
PKA-mediated phosphorylation of CREB	19	1.30e-01	-0.201000	1.66e-01
Acetylcholine regulates insulin secretion	10	2.72e-01	0.201000	3.20e-01
PD-1 signaling	21	1.12e-01	0.200000	1.46e-01
Presynaptic depolarization and calcium channel opening	12	2.29e-01	-0.200000	2.77e-01
Signaling by BRAF and RAF1 fusions	60	7.86e-03	-0.198000	1.56e-02
TP53 Regulates Transcription of Caspase Activators and Caspases	12	2.35e-01	-0.198000	2.82e-01
Reactions specific to the complex N-glycan synthesis pathway	10	2.78e-01	-0.198000	3.27e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	3.97e-02	-0.198000	6.10e-02
E2F mediated regulation of DNA replication	20	1.25e-01	-0.198000	1.61e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	2.36e-01	-0.198000	2.83e-01
Glucagon signaling in metabolic regulation	33	4.94e-02	-0.198000	7.31e-02
Negative regulation of FGFR2 signaling	33	4.94e-02	-0.198000	7.31e-02
Transmission across Chemical Synapses	237	1.56e-07	-0.198000	1.25e-06
Semaphorin interactions	61	7.84e-03	-0.197000	1.56e-02
G alpha (12/13) signalling events	74	3.48e-03	-0.196000	7.95e-03
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	3.08e-02	0.195000	4.92e-02
Budding and maturation of HIV virion	28	7.47e-02	-0.195000	1.05e-01
RAC2 GTPase cycle	80	2.66e-03	-0.194000	6.25e-03
Aggrephagy	23	1.09e-01	-0.193000	1.44e-01
Phase 2 - plateau phase	14	2.12e-01	-0.192000	2.58e-01
RAC1 GTPase cycle	170	1.50e-05	-0.192000	6.79e-05
p38MAPK events	13	2.31e-01	-0.192000	2.78e-01
PLC beta mediated events	47	2.28e-02	-0.192000	3.84e-02
Integrin signaling	27	8.64e-02	-0.191000	1.19e-01
Phosphorylation of the APC/C	20	1.40e-01	-0.190000	1.77e-01
TAK1-dependent IKK and NF-kappa-B activation	25	9.97e-02	-0.190000	1.34e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	1.07e-01	-0.190000	1.41e-01
Interleukin-37 signaling	21	1.32e-01	-0.190000	1.68e-01
Defective B3GALTL causes PpS	36	4.84e-02	-0.190000	7.21e-02
Sensory perception of taste	47	2.42e-02	0.190000	4.01e-02
FGFR2 ligand binding and activation	19	1.53e-01	-0.190000	1.91e-01
SARS-CoV-2-host interactions	185	8.60e-06	-0.189000	4.20e-05
Butyrophilin (BTN) family interactions	12	2.56e-01	0.189000	3.04e-01
Interleukin-12 family signaling	54	1.64e-02	-0.189000	2.90e-02
GABA receptor activation	57	1.40e-02	-0.188000	2.56e-02
rRNA modification in the nucleus and cytosol	55	1.59e-02	-0.188000	2.84e-02
Macroautophagy	111	6.25e-04	-0.188000	1.81e-03
Developmental Biology	1020	2.71e-24	-0.187000	1.59e-22
RIPK1-mediated regulated necrosis	27	9.23e-02	-0.187000	1.25e-01
Regulation of necroptotic cell death	27	9.23e-02	-0.187000	1.25e-01
Dissolution of Fibrin Clot	13	2.43e-01	0.187000	2.91e-01
Metabolism of carbohydrates	275	9.33e-08	-0.187000	7.78e-07
PI Metabolism	79	4.15e-03	-0.186000	9.23e-03
IL-6-type cytokine receptor ligand interactions	17	1.83e-01	-0.186000	2.25e-01
Diseases of glycosylation	137	1.66e-04	-0.186000	5.71e-04
Metabolism of nucleotides	95	1.72e-03	-0.186000	4.27e-03
Integrin cell surface interactions	66	9.13e-03	-0.185000	1.78e-02
TCR signaling	112	7.31e-04	-0.185000	2.07e-03
IRF3-mediated induction of type I IFN	11	2.89e-01	-0.184000	3.39e-01
ADP signalling through P2Y purinoceptor 1	25	1.10e-01	-0.184000	1.45e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	1.76e-01	-0.184000	2.18e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	120	4.94e-04	0.184000	1.47e-03
RHOQ GTPase cycle	57	1.62e-02	-0.184000	2.89e-02
RAB GEFs exchange GTP for GDP on RABs	83	3.75e-03	-0.184000	8.49e-03
Regulation of insulin secretion	77	5.51e-03	-0.183000	1.17e-02
Suppression of phagosomal maturation	13	2.54e-01	-0.183000	3.03e-01
Intrinsic Pathway of Fibrin Clot Formation	21	1.47e-01	0.183000	1.85e-01
Autophagy	125	4.28e-04	-0.182000	1.31e-03
Vasopressin regulates renal water homeostasis via Aquaporins	42	4.12e-02	-0.182000	6.31e-02
Insulin receptor recycling	25	1.19e-01	-0.180000	1.55e-01
Disorders of transmembrane transporters	167	6.25e-05	-0.179000	2.36e-04
Glycosaminoglycan metabolism	116	8.42e-04	-0.179000	2.36e-03
Signaling by ERBB2 TMD/JMD mutants	21	1.55e-01	-0.179000	1.93e-01
Myogenesis	29	9.50e-02	-0.179000	1.28e-01
GPVI-mediated activation cascade	32	7.95e-02	-0.179000	1.10e-01
Azathioprine ADME	22	1.49e-01	-0.177000	1.87e-01
Metabolism	1967	2.90e-39	-0.177000	4.04e-37
Signaling by ERBB4	57	2.08e-02	-0.177000	3.57e-02
Vitamin D (calciferol) metabolism	12	2.89e-01	-0.177000	3.39e-01
Interconversion of nucleotide di- and triphosphates	29	1.01e-01	-0.176000	1.35e-01
Interleukin-12 signaling	44	4.36e-02	-0.176000	6.60e-02
Recycling pathway of L1	23	1.45e-01	-0.176000	1.83e-01
RHOG GTPase cycle	69	1.19e-02	-0.175000	2.24e-02
Caspase-mediated cleavage of cytoskeletal proteins	12	2.95e-01	-0.175000	3.45e-01
Transcriptional Regulation by VENTX	41	5.39e-02	-0.174000	7.87e-02
Factors involved in megakaryocyte development and platelet production	130	6.10e-04	-0.174000	1.77e-03
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	1.78e-01	-0.174000	2.20e-01
Miscellaneous substrates	12	2.99e-01	0.173000	3.49e-01
EPHA-mediated growth cone collapse	15	2.46e-01	-0.173000	2.95e-01
LGI-ADAM interactions	14	2.63e-01	-0.173000	3.12e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	1.82e-01	-0.172000	2.24e-01
Amino acids regulate mTORC1	52	3.14e-02	-0.172000	5.00e-02
Signaling by MET	66	1.54e-02	-0.172000	2.77e-02
Collagen formation	88	5.19e-03	-0.172000	1.11e-02
O-glycosylation of TSR domain-containing proteins	37	7.07e-02	-0.172000	9.93e-02
Integration of energy metabolism	106	2.27e-03	-0.171000	5.50e-03
Glycogen storage diseases	14	2.68e-01	-0.171000	3.16e-01
Purine catabolism	17	2.24e-01	-0.170000	2.71e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	3.29e-01	-0.170000	3.81e-01
CDC42 GTPase cycle	144	4.29e-04	-0.170000	1.31e-03
Triglyceride catabolism	23	1.60e-01	-0.169000	1.99e-01
Growth hormone receptor signaling	24	1.51e-01	-0.169000	1.90e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	31	1.04e-01	-0.169000	1.38e-01
Activation of the phototransduction cascade	11	3.32e-01	0.169000	3.85e-01
Basigin interactions	24	1.52e-01	-0.169000	1.91e-01
PKA activation in glucagon signalling	17	2.33e-01	-0.167000	2.80e-01
Thromboxane signalling through TP receptor	24	1.58e-01	-0.167000	1.96e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	15	2.65e-01	-0.166000	3.13e-01
Collagen biosynthesis and modifying enzymes	65	2.03e-02	-0.166000	3.51e-02
Depolymerisation of the Nuclear Lamina	14	2.84e-01	-0.165000	3.35e-01
Synthesis of PE	12	3.22e-01	-0.165000	3.74e-01
Androgen biosynthesis	11	3.43e-01	0.165000	3.95e-01
Fatty acid metabolism	167	2.40e-04	-0.165000	7.95e-04
Interaction between L1 and Ankyrins	28	1.34e-01	-0.164000	1.70e-01
SHC1 events in ERBB4 signaling	14	2.89e-01	-0.164000	3.39e-01
Metabolism of lipids	696	1.87e-13	-0.163000	3.70e-12
Pyruvate metabolism	29	1.29e-01	-0.163000	1.65e-01
Assembly of collagen fibrils and other multimeric structures	56	3.49e-02	-0.163000	5.46e-02
RHO GTPases activate PAKs	19	2.20e-01	-0.163000	2.66e-01
Signaling by Interleukins	426	8.12e-09	-0.163000	8.38e-08
IRAK4 deficiency (TLR2/4)	17	2.50e-01	0.161000	2.98e-01
Methylation	14	2.96e-01	-0.161000	3.47e-01
RAB geranylgeranylation	57	3.57e-02	-0.161000	5.58e-02
Scavenging of heme from plasma	12	3.35e-01	0.161000	3.87e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	2.70e-01	-0.159000	3.19e-01
The role of Nef in HIV-1 replication and disease pathogenesis	27	1.57e-01	-0.157000	1.96e-01
MET promotes cell motility	29	1.45e-01	-0.156000	1.83e-01
Oncogene Induced Senescence	35	1.10e-01	-0.156000	1.44e-01
Formation of apoptosome	10	3.93e-01	-0.156000	4.44e-01
Regulation of the apoptosome activity	10	3.93e-01	-0.156000	4.44e-01
Nucleotide catabolism	35	1.10e-01	-0.156000	1.45e-01
Sphingolipid de novo biosynthesis	41	8.49e-02	-0.155000	1.17e-01
CASP8 activity is inhibited	11	3.73e-01	-0.155000	4.27e-01
Dimerization of procaspase-8	11	3.73e-01	-0.155000	4.27e-01
Regulation by c-FLIP	11	3.73e-01	-0.155000	4.27e-01
Neurotransmitter receptors and postsynaptic signal transmission	175	4.14e-04	-0.155000	1.27e-03
Muscle contraction	186	2.88e-04	-0.154000	9.27e-04
Diseases of metabolism	234	4.91e-05	-0.154000	1.94e-04
Nuclear signaling by ERBB4	32	1.33e-01	-0.153000	1.70e-01
Role of phospholipids in phagocytosis	23	2.04e-01	-0.153000	2.48e-01
Trafficking and processing of endosomal TLR	11	3.80e-01	0.153000	4.34e-01
Metabolism of vitamins and cofactors	181	3.94e-04	-0.153000	1.22e-03
Carnitine metabolism	11	3.84e-01	-0.152000	4.36e-01
Regulation of signaling by NODAL	11	3.84e-01	0.151000	4.37e-01
Phospholipid metabolism	192	3.31e-04	-0.150000	1.05e-03
Smooth Muscle Contraction	39	1.09e-01	-0.148000	1.43e-01
Metabolism of steroid hormones	33	1.42e-01	0.148000	1.79e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	4.19e-01	-0.148000	4.69e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	2.01e-01	-0.148000	2.45e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	3.07e-01	-0.147000	3.57e-01
Adaptive Immune System	711	3.78e-11	-0.145000	5.24e-10
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21	2.50e-01	0.145000	2.99e-01
Tie2 Signaling	18	2.89e-01	-0.144000	3.39e-01
Cell-Cell communication	112	8.43e-03	-0.144000	1.65e-02
Signal transduction by L1	20	2.67e-01	-0.143000	3.16e-01
Generation of second messenger molecules	30	1.75e-01	0.143000	2.17e-01
Vitamin B5 (pantothenate) metabolism	16	3.22e-01	-0.143000	3.74e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	101	1.35e-02	-0.142000	2.50e-02
Ion homeostasis	50	8.33e-02	-0.142000	1.15e-01
Metabolism of water-soluble vitamins and cofactors	118	7.88e-03	-0.142000	1.56e-02
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	1.18e-01	-0.141000	1.53e-01
Signaling by RAS mutants	41	1.18e-01	-0.141000	1.53e-01
Signaling by moderate kinase activity BRAF mutants	41	1.18e-01	-0.141000	1.53e-01
Signaling downstream of RAS mutants	41	1.18e-01	-0.141000	1.53e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	1.91e-01	-0.140000	2.34e-01
Trafficking of AMPA receptors	29	1.91e-01	-0.140000	2.34e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	3.82e-01	-0.140000	4.35e-01
Formation of Fibrin Clot (Clotting Cascade)	37	1.40e-01	0.140000	1.77e-01
Diseases associated with glycosaminoglycan metabolism	38	1.35e-01	-0.140000	1.72e-01
Drug ADME	98	1.68e-02	0.140000	2.96e-02
Platelet Adhesion to exposed collagen	13	3.84e-01	0.139000	4.37e-01
Interleukin-4 and Interleukin-13 signaling	104	1.52e-02	-0.138000	2.75e-02
PI3K events in ERBB2 signaling	16	3.42e-01	-0.137000	3.94e-01
Costimulation by the CD28 family	65	5.58e-02	-0.137000	8.10e-02
Cargo concentration in the ER	32	1.82e-01	-0.136000	2.24e-01
Aquaporin-mediated transport	51	9.38e-02	-0.136000	1.27e-01
Adenylate cyclase activating pathway	10	4.59e-01	-0.135000	5.08e-01
Cytokine Signaling in Immune system	667	2.57e-09	-0.135000	2.91e-08
RAC3 GTPase cycle	84	3.27e-02	-0.135000	5.17e-02
SARS-CoV-2 activates/modulates innate and adaptive immune responses	112	1.39e-02	-0.135000	2.54e-02
Spry regulation of FGF signaling	16	3.52e-01	-0.134000	4.05e-01
Pre-NOTCH Transcription and Translation	45	1.20e-01	-0.134000	1.55e-01
Transport of small molecules	689	1.98e-09	-0.134000	2.29e-08
Negative regulation of MET activity	20	3.01e-01	-0.133000	3.51e-01
Ion transport by P-type ATPases	51	1.00e-01	-0.133000	1.34e-01
Biosynthesis of specialized proresolving mediators (SPMs)	19	3.16e-01	-0.133000	3.68e-01
Triglyceride metabolism	36	1.68e-01	-0.133000	2.09e-01
Regulation of RUNX1 Expression and Activity	25	2.53e-01	-0.132000	3.01e-01
HSF1-dependent transactivation	35	1.77e-01	-0.132000	2.19e-01
Caspase activation via Death Receptors in the presence of ligand	16	3.65e-01	-0.131000	4.19e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	38	1.63e-01	-0.131000	2.02e-01
Glycerophospholipid biosynthesis	114	1.58e-02	-0.131000	2.83e-02
Signaling by EGFR in Cancer	25	2.60e-01	-0.130000	3.09e-01
CS/DS degradation	12	4.37e-01	-0.129000	4.87e-01
EGFR downregulation	30	2.23e-01	-0.129000	2.69e-01
Platelet activation, signaling and aggregation	246	5.28e-04	-0.128000	1.56e-03
Pre-NOTCH Expression and Processing	61	8.49e-02	-0.127000	1.17e-01
RAS processing	19	3.40e-01	-0.126000	3.93e-01
CD28 dependent Vav1 pathway	11	4.71e-01	-0.126000	5.20e-01
PI3K events in ERBB4 signaling	10	4.97e-01	-0.124000	5.44e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	4.07e-01	0.124000	4.57e-01
The NLRP3 inflammasome	16	3.95e-01	-0.123000	4.45e-01
Nucleotide salvage	21	3.33e-01	-0.122000	3.85e-01
Regulation of TP53 Activity through Methylation	18	3.72e-01	-0.121000	4.27e-01
Bicarbonate transporters	10	5.07e-01	-0.121000	5.54e-01
SLC transporter disorders	92	4.68e-02	-0.120000	7.00e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	1.47e-01	-0.120000	1.84e-01
NOTCH2 intracellular domain regulates transcription	11	4.92e-01	-0.120000	5.40e-01
Biosynthesis of DHA-derived SPMs	17	3.93e-01	-0.120000	4.44e-01
C-type lectin receptors (CLRs)	137	1.61e-02	-0.119000	2.87e-02
Interleukin-2 family signaling	40	1.94e-01	-0.119000	2.37e-01
Peptide ligand-binding receptors	190	4.89e-03	0.118000	1.05e-02
Fanconi Anemia Pathway	37	2.14e-01	-0.118000	2.60e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	2.36e-01	-0.117000	2.83e-01
Pregnenolone biosynthesis	10	5.21e-01	0.117000	5.68e-01
Metabolism of amine-derived hormones	17	4.03e-01	0.117000	4.54e-01
Sema3A PAK dependent Axon repulsion	14	4.52e-01	-0.116000	5.02e-01
Thyroxine biosynthesis	10	5.26e-01	0.116000	5.72e-01
STING mediated induction of host immune responses	13	4.73e-01	-0.115000	5.22e-01
ERBB2 Regulates Cell Motility	15	4.41e-01	-0.115000	4.91e-01
MET activates PTK2 signaling	18	3.99e-01	-0.115000	4.50e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	16	4.27e-01	0.115000	4.77e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	3.34e-01	0.114000	3.86e-01
Phase 4 - resting membrane potential	19	3.90e-01	-0.114000	4.42e-01
Tryptophan catabolism	12	4.97e-01	0.113000	5.44e-01
Metalloprotease DUBs	19	3.94e-01	-0.113000	4.45e-01
Free fatty acids regulate insulin secretion	10	5.37e-01	0.113000	5.82e-01
Interferon alpha/beta signaling	71	1.01e-01	-0.113000	1.35e-01
Passive transport by Aquaporins	13	4.83e-01	0.112000	5.31e-01
Organic cation transport	10	5.38e-01	-0.112000	5.83e-01
Termination of O-glycan biosynthesis	25	3.33e-01	0.112000	3.85e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77	9.02e-02	-0.112000	1.23e-01
NOD1/2 Signaling Pathway	29	2.99e-01	-0.111000	3.49e-01
Extracellular matrix organization	288	1.15e-03	-0.111000	3.09e-03
Post-translational protein phosphorylation	100	5.65e-02	-0.110000	8.20e-02
Organic anion transporters	10	5.46e-01	-0.110000	5.90e-01
Plasma lipoprotein assembly, remodeling, and clearance	73	1.04e-01	-0.110000	1.38e-01
Signaling by NODAL	22	3.72e-01	-0.110000	4.27e-01
Platelet Aggregation (Plug Formation)	37	2.49e-01	-0.109000	2.98e-01
Hemostasis	560	9.39e-06	-0.109000	4.55e-05
Hyaluronan metabolism	17	4.36e-01	-0.109000	4.86e-01
Post-chaperonin tubulin folding pathway	23	3.68e-01	-0.108000	4.23e-01
Diseases of carbohydrate metabolism	30	3.11e-01	-0.107000	3.62e-01
FCGR3A-mediated IL10 synthesis	37	2.63e-01	-0.106000	3.12e-01
Tandem pore domain potassium channels	12	5.27e-01	-0.105000	5.73e-01
Synthesis of very long-chain fatty acyl-CoAs	23	3.83e-01	-0.105000	4.36e-01
Sodium/Calcium exchangers	11	5.47e-01	-0.105000	5.90e-01
The canonical retinoid cycle in rods (twilight vision)	23	3.85e-01	0.105000	4.37e-01
Collagen chain trimerization	42	2.42e-01	-0.104000	2.90e-01
Metabolism of steroids	148	2.86e-02	-0.104000	4.60e-02
Beta-oxidation of very long chain fatty acids	10	5.75e-01	-0.102000	6.18e-01
Pre-NOTCH Processing in Golgi	18	4.56e-01	-0.101000	5.05e-01
Interferon Signaling	194	1.59e-02	-0.100000	2.84e-02
Glutathione conjugation	37	2.91e-01	-0.100000	3.41e-01
Leishmania infection	245	7.04e-03	-0.099800	1.44e-02
MHC class II antigen presentation	104	7.86e-02	-0.099700	1.09e-01
Adherens junctions interactions	26	3.82e-01	-0.098900	4.36e-01
Cell junction organization	79	1.29e-01	-0.098800	1.65e-01
G-protein activation	24	4.04e-01	-0.098400	4.54e-01
Signaling by RAF1 mutants	37	3.00e-01	-0.098400	3.50e-01
Inflammasomes	21	4.36e-01	-0.098100	4.86e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	5.26e-01	-0.097900	5.72e-01
Ion channel transport	168	2.93e-02	-0.097400	4.71e-02
Metabolic disorders of biological oxidation enzymes	32	3.44e-01	-0.096600	3.96e-01
N-glycan antennae elongation in the medial/trans-Golgi	26	3.94e-01	-0.096600	4.45e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	4.56e-01	-0.096200	5.05e-01
Xenobiotics	24	4.15e-01	0.096200	4.65e-01
Regulation of innate immune responses to cytosolic DNA	14	5.37e-01	-0.095200	5.82e-01
CYP2E1 reactions	11	5.85e-01	0.095100	6.25e-01
Chylomicron assembly	10	6.05e-01	0.094500	6.45e-01
activated TAK1 mediates p38 MAPK activation	16	5.14e-01	-0.094200	5.61e-01
Advanced glycosylation endproduct receptor signaling	13	5.61e-01	-0.093200	6.04e-01
SHC1 events in ERBB2 signaling	22	4.55e-01	-0.092100	5.04e-01
HSF1 activation	27	4.11e-01	-0.091400	4.61e-01
Glucagon-type ligand receptors	33	3.71e-01	-0.089900	4.26e-01
p130Cas linkage to MAPK signaling for integrins	15	5.47e-01	-0.089800	5.90e-01
Gap junction trafficking and regulation	29	4.03e-01	-0.089600	4.54e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	10	6.26e-01	-0.088900	6.65e-01
Amyloid fiber formation	53	2.64e-01	-0.088700	3.12e-01
Gap junction trafficking	27	4.25e-01	-0.088700	4.75e-01
Regulation of IFNA/IFNB signaling	24	4.54e-01	0.088400	5.04e-01
Nicotinamide salvaging	17	5.28e-01	-0.088300	5.74e-01
Downregulation of ERBB2 signaling	28	4.26e-01	-0.087000	4.76e-01
HDL remodeling	10	6.36e-01	-0.086500	6.74e-01
ECM proteoglycans	55	2.69e-01	-0.086100	3.18e-01
Class A/1 (Rhodopsin-like receptors)	312	8.88e-03	0.086000	1.74e-02
ABC transporters in lipid homeostasis	17	5.39e-01	0.086000	5.83e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	29	4.26e-01	-0.085400	4.76e-01
Signal regulatory protein family interactions	13	5.96e-01	0.084900	6.36e-01
Synthesis of PIPs at the Golgi membrane	17	5.44e-01	0.084900	5.88e-01
Metabolism of fat-soluble vitamins	46	3.26e-01	-0.083700	3.78e-01
Lysine catabolism	12	6.17e-01	-0.083400	6.56e-01
Reproduction	82	2.00e-01	-0.081900	2.43e-01
Attenuation phase	25	4.84e-01	-0.080800	5.32e-01
Hyaluronan uptake and degradation	12	6.29e-01	-0.080600	6.67e-01
Immune System	1877	5.73e-09	-0.080500	6.04e-08
TNFs bind their physiological receptors	25	4.94e-01	0.079000	5.42e-01
GAB1 signalosome	17	5.77e-01	-0.078200	6.19e-01
Stimuli-sensing channels	96	1.89e-01	-0.077500	2.32e-01
Prolactin receptor signaling	15	6.07e-01	0.076700	6.46e-01
RHO GTPases Activate NADPH Oxidases	22	5.33e-01	0.076700	5.79e-01
Thrombin signalling through proteinase activated receptors (PARs)	32	4.60e-01	-0.075500	5.08e-01
Response to elevated platelet cytosolic Ca2+	121	1.52e-01	-0.075300	1.90e-01
Amine ligand-binding receptors	41	4.09e-01	-0.074400	4.60e-01
G alpha (s) signalling events	153	1.12e-01	-0.074300	1.47e-01
O-linked glycosylation	107	1.86e-01	-0.073900	2.29e-01
The phototransduction cascade	32	4.78e-01	0.072400	5.26e-01
Transport of vitamins, nucleosides, and related molecules	38	4.43e-01	0.071900	4.93e-01
Aspartate and asparagine metabolism	12	6.67e-01	-0.071800	7.00e-01
Na+/Cl- dependent neurotransmitter transporters	18	6.00e-01	0.071400	6.40e-01
Neutrophil degranulation	458	9.26e-03	-0.070800	1.80e-02
Amino acid transport across the plasma membrane	30	5.03e-01	-0.070600	5.51e-01
Peptide hormone metabolism	83	2.70e-01	-0.070000	3.19e-01
Acyl chain remodelling of PS	21	5.80e-01	0.069800	6.22e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	6.44e-01	-0.069000	6.79e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	6.44e-01	-0.069000	6.79e-01
DAP12 interactions	40	4.57e-01	-0.068000	5.06e-01
Phase II - Conjugation of compounds	109	2.21e-01	0.067800	2.67e-01
RA biosynthesis pathway	22	5.82e-01	-0.067800	6.23e-01
Triglyceride biosynthesis	13	6.73e-01	-0.067600	7.05e-01
Regulated Necrosis	53	4.01e-01	-0.066700	4.52e-01
Keratan sulfate/keratin metabolism	33	5.11e-01	-0.066200	5.58e-01
Trafficking of GluR2-containing AMPA receptors	15	6.58e-01	-0.066100	6.93e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	31	5.29e-01	-0.065300	5.74e-01
Platelet degranulation	116	2.25e-01	-0.065200	2.71e-01
Detoxification of Reactive Oxygen Species	35	5.07e-01	-0.064800	5.54e-01
Paracetamol ADME	30	5.41e-01	0.064500	5.85e-01
Alpha-protein kinase 1 signaling pathway	10	7.26e-01	-0.064100	7.56e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14	6.78e-01	-0.064100	7.11e-01
Chondroitin sulfate biosynthesis	18	6.38e-01	-0.064000	6.76e-01
Pyrimidine catabolism	12	7.02e-01	-0.063900	7.33e-01
Endogenous sterols	26	5.76e-01	-0.063400	6.19e-01
Gap junction assembly	18	6.42e-01	0.063300	6.78e-01
Peptide hormone biosynthesis	11	7.17e-01	0.063200	7.48e-01
Diseases associated with O-glycosylation of proteins	66	3.77e-01	-0.062900	4.31e-01
Phase I - Functionalization of compounds	100	2.87e-01	0.061600	3.37e-01
Binding and Uptake of Ligands by Scavenger Receptors	41	4.95e-01	0.061500	5.43e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	5.77e-01	-0.060900	6.19e-01
Cellular hexose transport	21	6.39e-01	0.059100	6.76e-01
Anti-inflammatory response favouring Leishmania parasite infection	164	1.94e-01	-0.058700	2.37e-01
Leishmania parasite growth and survival	164	1.94e-01	-0.058700	2.37e-01
Pyroptosis	26	6.05e-01	0.058500	6.45e-01
Signaling by high-kinase activity BRAF mutants	32	5.69e-01	-0.058100	6.12e-01
Chaperone Mediated Autophagy	19	6.63e-01	-0.057700	6.97e-01
Assembly of the ORC complex at the origin of replication	10	7.53e-01	-0.057400	7.81e-01
Inactivation, recovery and regulation of the phototransduction cascade	31	5.81e-01	0.057200	6.23e-01
ROS and RNS production in phagocytes	35	5.59e-01	-0.057000	6.02e-01
Organic cation/anion/zwitterion transport	15	7.06e-01	0.056300	7.36e-01
Keratan sulfate degradation	12	7.36e-01	0.056200	7.64e-01
SLC-mediated transmembrane transport	238	1.53e-01	-0.053700	1.91e-01
CD209 (DC-SIGN) signaling	20	6.79e-01	-0.053400	7.11e-01
Synthesis of PA	35	5.86e-01	-0.053100	6.26e-01
Interferon gamma signaling	90	3.89e-01	-0.052500	4.41e-01
Other semaphorin interactions	18	7.01e-01	-0.052200	7.33e-01
TRP channels	24	6.59e-01	-0.051900	6.94e-01
N-Glycan antennae elongation	15	7.31e-01	-0.051300	7.60e-01
Biological oxidations	216	1.97e-01	0.050900	2.40e-01
Blood group systems biosynthesis	22	6.80e-01	0.050800	7.12e-01
Surfactant metabolism	29	6.39e-01	0.050400	6.76e-01
Eicosanoid ligand-binding receptors	14	7.52e-01	-0.048900	7.80e-01
ERBB2 Activates PTK6 Signaling	13	7.63e-01	0.048200	7.90e-01
O-linked glycosylation of mucins	62	5.12e-01	-0.048200	5.59e-01
Tight junction interactions	28	6.59e-01	0.048100	6.94e-01
Chylomicron remodeling	10	7.93e-01	0.047900	8.18e-01
Mucopolysaccharidoses	10	8.01e-01	-0.046100	8.26e-01
Bile acid and bile salt metabolism	45	5.96e-01	0.045700	6.36e-01
Innate Immune System	999	1.63e-02	-0.044700	2.90e-02
Signaling by GPCR	671	4.76e-02	-0.044700	7.11e-02
Visual phototransduction	93	4.57e-01	0.044600	5.06e-01
Synthesis of PIPs at the early endosome membrane	15	7.68e-01	-0.044000	7.94e-01
Late endosomal microautophagy	32	6.71e-01	-0.043400	7.04e-01
MAP2K and MAPK activation	36	6.55e-01	-0.043000	6.90e-01
Cell surface interactions at the vascular wall	129	4.20e-01	0.041100	4.70e-01
Interleukin-20 family signaling	25	7.23e-01	-0.040900	7.54e-01
SHC1 events in EGFR signaling	14	7.92e-01	-0.040700	8.18e-01
Retinoid metabolism and transport	42	6.50e-01	-0.040400	6.86e-01
Cytochrome P450 - arranged by substrate type	64	5.85e-01	0.039500	6.25e-01
Pyrimidine salvage	10	8.30e-01	0.039200	8.51e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	117	4.75e-01	-0.038200	5.23e-01
Gastrin-CREB signalling pathway via PKC and MAPK	17	7.87e-01	-0.037800	8.13e-01
Cell-cell junction organization	56	6.25e-01	-0.037800	6.64e-01
Response to metal ions	14	8.08e-01	-0.037400	8.32e-01
Metallothioneins bind metals	11	8.31e-01	-0.037100	8.52e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	8.12e-01	-0.036800	8.34e-01
Cytosolic sulfonation of small molecules	23	7.63e-01	0.036300	7.90e-01
ADORA2B mediated anti-inflammatory cytokines production	132	4.73e-01	-0.036200	5.21e-01
GRB2 events in ERBB2 signaling	16	8.02e-01	-0.036100	8.27e-01
G alpha (q) signalling events	206	3.78e-01	-0.035600	4.32e-01
Glyoxylate metabolism and glycine degradation	30	7.37e-01	-0.035300	7.66e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	43	6.91e-01	0.035000	7.23e-01
Plasma lipoprotein remodeling	32	7.34e-01	0.034600	7.63e-01
Diseases associated with visual transduction	11	8.43e-01	-0.034500	8.61e-01
Diseases of the neuronal system	11	8.43e-01	-0.034500	8.61e-01
Retinoid cycle disease events	11	8.43e-01	-0.034500	8.61e-01
GPCR ligand binding	444	2.64e-01	0.030800	3.13e-01
Lewis blood group biosynthesis	18	8.23e-01	0.030500	8.44e-01
Acyl chain remodelling of PE	24	8.07e-01	-0.028800	8.31e-01
Plasma lipoprotein assembly	19	8.33e-01	0.028000	8.53e-01
Abacavir ADME	10	8.80e-01	-0.027700	8.90e-01
GPCR downstream signalling	604	2.46e-01	-0.027600	2.95e-01
Aflatoxin activation and detoxification	20	8.35e-01	-0.026800	8.55e-01
Keratan sulfate biosynthesis	28	8.09e-01	0.026400	8.32e-01
Metabolism of porphyrins	27	8.14e-01	-0.026100	8.36e-01
Degradation of the extracellular matrix	108	6.42e-01	-0.025900	6.78e-01
Phenylalanine and tyrosine metabolism	10	8.89e-01	0.025600	8.99e-01
Nucleotide-like (purinergic) receptors	13	8.79e-01	0.024400	8.90e-01
NR1H2 and NR1H3-mediated signaling	53	7.64e-01	0.023900	7.90e-01
Assembly of active LPL and LIPC lipase complexes	17	8.71e-01	0.022700	8.86e-01
Serotonin receptors	11	8.98e-01	-0.022400	9.07e-01
Acyl chain remodelling of PG	18	8.71e-01	0.022100	8.86e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	9.04e-01	-0.022000	9.13e-01
Post-translational modification: synthesis of GPI-anchored proteins	90	7.31e-01	-0.021000	7.60e-01
FGFR2b ligand binding and activation	10	9.09e-01	-0.020900	9.15e-01
PIWI-interacting RNA (piRNA) biogenesis	29	8.53e-01	-0.019900	8.70e-01
Striated Muscle Contraction	33	8.44e-01	0.019800	8.61e-01
Nicotinate metabolism	29	8.55e-01	0.019600	8.72e-01
GRB2 events in EGFR signaling	13	9.08e-01	0.018500	9.15e-01
Cell recruitment (pro-inflammatory response)	25	8.77e-01	0.017900	8.89e-01
Purinergic signaling in leishmaniasis infection	25	8.77e-01	0.017900	8.89e-01
Regulation of BACH1 activity	15	9.06e-01	0.017500	9.15e-01
Diseases associated with the TLR signaling cascade	29	8.76e-01	-0.016700	8.89e-01
Diseases of Immune System	29	8.76e-01	-0.016700	8.89e-01
Synthesis of bile acids and bile salts	34	8.71e-01	-0.016100	8.86e-01
Hormone ligand-binding receptors	13	9.21e-01	-0.015900	9.26e-01
Regulation of localization of FOXO transcription factors	11	9.31e-01	-0.015100	9.35e-01
Carboxyterminal post-translational modifications of tubulin	40	8.74e-01	-0.014500	8.88e-01
Acyl chain remodelling of PI	16	9.30e-01	-0.012600	9.35e-01
Acyl chain remodelling of PC	26	9.11e-01	0.012600	9.17e-01
Transport of bile salts and organic acids, metal ions and amine compounds	84	8.62e-01	-0.011000	8.78e-01
Arachidonic acid metabolism	56	9.07e-01	-0.009020	9.15e-01
TRAF6 mediated IRF7 activation	28	9.44e-01	-0.007630	9.48e-01
Synthesis of PIPs at the late endosome membrane	10	9.71e-01	-0.006730	9.72e-01
Collagen degradation	39	9.47e-01	-0.006180	9.49e-01
Scavenging by Class A Receptors	19	9.64e-01	-0.005970	9.66e-01
FCGR activation	12	9.77e-01	0.004800	9.78e-01
G alpha (i) signalling events	306	9.47e-01	0.002230	9.49e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	13	9.98e-01	-0.000412	9.98e-01

---

Detailed Gene set reports

NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus

	781
set	NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize	11
pANOVA	8.76e-05
s.dist	-0.683
p.adjustANOVA	0.000319

Top enriched genes

Top 20 genes

GeneID	Gene Rank
JAG1	-21360
NOTCH4	-21287
DLL4	-20878
PSENEN	-19973
NCSTN	-19875
ADAM10	-19475
YWHAZ	-19306
PSEN2	-15833
APH1A	-14503
PSEN1	-14280
APH1B	-12418

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
JAG1	-21360
NOTCH4	-21287
DLL4	-20878
PSENEN	-19973
NCSTN	-19875
ADAM10	-19475
YWHAZ	-19306
PSEN2	-15833
APH1A	-14503
PSEN1	-14280
APH1B	-12418

---

Folding of actin by CCT/TriC

Folding of actin by CCT/TriC

	441
set	Folding of actin by CCT/TriC
setSize	10
pANOVA	0.000321
s.dist	-0.657
p.adjustANOVA	0.00102

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACTB	-22171
CCT7	-21412
CCT8	-21371
CCT6A	-20690
CCT6B	-20184
CCT5	-16918
CCT3	-15816
CCT4	-13890
TCP1	-13518
CCT2	-11715

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACTB	-22171
CCT7	-21412
CCT8	-21371
CCT6A	-20690
CCT6B	-20184
CCT5	-16918
CCT3	-15816
CCT4	-13890
TCP1	-13518
CCT2	-11715

---

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

	884
set	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
setSize	10
pANOVA	0.000441
s.dist	-0.642
p.adjustANOVA	0.00134

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GSC	-22136
CDX2	-21943
SOX2	-20908
GATA6	-20847
EOMES	-20771
TSC22D1	-20503
HHEX	-18090
DKK1	-17501
POU5F1	-11128
NANOG	-1871

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GSC	-22136
CDX2	-21943
SOX2	-20908
GATA6	-20847
EOMES	-20771
TSC22D1	-20503
HHEX	-18090
DKK1	-17501
POU5F1	-11128
NANOG	-1871

---

FOXO-mediated transcription of cell cycle genes

FOXO-mediated transcription of cell cycle genes

	426
set	FOXO-mediated transcription of cell cycle genes
setSize	16
pANOVA	1.14e-05
s.dist	-0.633
p.adjustANOVA	5.38e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1B	-21959
BTG1	-21748
FOXG1	-20809
KLF4	-20700
SMAD4	-20058
CAV1	-19497
FOXO3	-19271
CCNG2	-18266
GADD45A	-17402
RBL2	-17393
PCBP4	-17364
SMAD2	-15922
MSTN	-14864
CDKN1A	-14697
SMAD3	-12366
FOXO1	-7044

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1B	-21959
BTG1	-21748
FOXG1	-20809
KLF4	-20700
SMAD4	-20058
CAV1	-19497
FOXO3	-19271
CCNG2	-18266
GADD45A	-17402
RBL2	-17393
PCBP4	-17364
SMAD2	-15922
MSTN	-14864
CDKN1A	-14697
SMAD3	-12366
FOXO1	-7044

---

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

	1364
set	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
setSize	14
pANOVA	6.49e-05
s.dist	-0.616
p.adjustANOVA	0.000242

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1B	-21959
E2F8	-21720
CCNA1	-21312
CCNA2	-20564
CCNE1	-20486
E2F1	-18887
TP53	-17874
PCBP4	-17364
CDK2	-15834
CDKN1A	-14697
CCNE2	-14252
ZNF385A	-14207
E2F7	-13768
ARID3A	-8412

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1B	-21959
E2F8	-21720
CCNA1	-21312
CCNA2	-20564
CCNE1	-20486
E2F1	-18887
TP53	-17874
PCBP4	-17364
CDK2	-15834
CDKN1A	-14697
CCNE2	-14252
ZNF385A	-14207
E2F7	-13768
ARID3A	-8412

---

Crosslinking of collagen fibrils

Crosslinking of collagen fibrils

	243
set	Crosslinking of collagen fibrils
setSize	10
pANOVA	0.000919
s.dist	-0.605
p.adjustANOVA	0.00256

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LOXL3	-22111
TLL1	-20810
PCOLCE	-20556
TLL2	-20345
LOX	-20308
LOXL1	-17356
LOXL2	-16916
PXDN	-11580
BMP1	-11057
LOXL4	-9883

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LOXL3	-22111
TLL1	-20810
PCOLCE	-20556
TLL2	-20345
LOX	-20308
LOXL1	-17356
LOXL2	-16916
PXDN	-11580
BMP1	-11057
LOXL4	-9883

---

Beta defensins

Beta defensins

	117
set	Beta defensins
setSize	32
pANOVA	4.06e-09
s.dist	0.6
p.adjustANOVA	4.37e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DEFB123	3768.0
DEFB118	3552.0
DEFB133	3465.0
DEFB108B	3283.0
TLR1	3203.0
DEFB107A	3180.5
DEFB125	3161.0
CCR2	3019.0
DEFB132	2744.0
DEFB105A	2371.5
DEFB119	2113.0
CCR6	1702.0
DEFB1	1600.0
DEFB124	0.5
DEFB103A	0.5
DEFB113	0.5
DEFB110	0.5
DEFB115	-1287.0
DEFB135	-1288.0
DEFB129	-2039.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DEFB123	3768.0
DEFB118	3552.0
DEFB133	3465.0
DEFB108B	3283.0
TLR1	3203.0
DEFB107A	3180.5
DEFB125	3161.0
CCR2	3019.0
DEFB132	2744.0
DEFB105A	2371.5
DEFB119	2113.0
CCR6	1702.0
DEFB1	1600.0
DEFB124	0.5
DEFB103A	0.5
DEFB113	0.5
DEFB110	0.5
DEFB115	-1287.0
DEFB135	-1288.0
DEFB129	-2039.0
DEFB116	-2165.0
DEFB127	-2806.0
DEFB134	-3602.0
DEFB131	-3603.0
DEFB121	-5345.0
DEFB104A	-5438.5
DEFB106A	-5880.5
DEFB126	-5934.0
DEFB114	-6212.0
DEFB136	-9321.0
DEFB128	-9580.0
TLR2	-15735.0

---

Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs

	955
set	Processing of Intronless Pre-mRNAs
setSize	19
pANOVA	5.84e-06
s.dist	-0.6
p.adjustANOVA	2.96e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-22145
PAPOLA	-21456
CPSF2	-21426
CSTF3	-21221
CPSF3	-21122
CLP1	-20845
CSTF1	-20351
CPSF4	-19721
FIP1L1	-19191
SYMPK	-18128
NUDT21	-17457
PCF11	-16163
CPSF6	-15885
NCBP2	-15174
WDR33	-14523
CPSF7	-14212
CPSF1	-14065
CSTF2T	-8314
PABPN1	-2129

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-22145
PAPOLA	-21456
CPSF2	-21426
CSTF3	-21221
CPSF3	-21122
CLP1	-20845
CSTF1	-20351
CPSF4	-19721
FIP1L1	-19191
SYMPK	-18128
NUDT21	-17457
PCF11	-16163
CPSF6	-15885
NCBP2	-15174
WDR33	-14523
CPSF7	-14212
CPSF1	-14065
CSTF2T	-8314
PABPN1	-2129

---

RUNX3 regulates p14-ARF

RUNX3 regulates p14-ARF

	1052
set	RUNX3 regulates p14-ARF
setSize	10
pANOVA	0.00103
s.dist	-0.599
p.adjustANOVA	0.00284

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BRD2	-22218
KRAS	-22156
RUNX3	-20951
CCND1	-20852
CBFB	-20421
TGFB1	-16561
HDAC4	-13653
RUNX1	-13643
EP300	-11115
CDKN2A	-8573

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BRD2	-22218
KRAS	-22156
RUNX3	-20951
CCND1	-20852
CBFB	-20421
TGFB1	-16561
HDAC4	-13653
RUNX1	-13643
EP300	-11115
CDKN2A	-8573

---

Defensins

Defensins

	299
set	Defensins
setSize	40
pANOVA	1.94e-10
s.dist	0.581
p.adjustANOVA	2.41e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DEFB123	3768.0
DEFA1	3582.5
DEFB118	3552.0
DEFB133	3465.0
DEFB108B	3283.0
DEFA3	3257.0
TLR1	3203.0
DEFB107A	3180.5
DEFB125	3161.0
CCR2	3019.0
DEFB132	2744.0
DEFB105A	2371.5
DEFB119	2113.0
CCR6	1702.0
DEFB1	1600.0
DEFA6	0.5
DEFB124	0.5
DEFB103A	0.5
DEFB113	0.5
DEFB110	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DEFB123	3768.0
DEFA1	3582.5
DEFB118	3552.0
DEFB133	3465.0
DEFB108B	3283.0
DEFA3	3257.0
TLR1	3203.0
DEFB107A	3180.5
DEFB125	3161.0
CCR2	3019.0
DEFB132	2744.0
DEFB105A	2371.5
DEFB119	2113.0
CCR6	1702.0
DEFB1	1600.0
DEFA6	0.5
DEFB124	0.5
DEFB103A	0.5
DEFB113	0.5
DEFB110	0.5
DEFB115	-1287.0
DEFB135	-1288.0
DEFA4	-1517.0
PRSS3	-1961.0
DEFB129	-2039.0
DEFB116	-2165.0
DEFB127	-2806.0
DEFB134	-3602.0
DEFB131	-3603.0
DEFB121	-5345.0
DEFB104A	-5438.5
DEFA5	-5568.0
CD4	-5690.0
DEFB106A	-5880.5
DEFB126	-5934.0
DEFB114	-6212.0
DEFB136	-9321.0
DEFB128	-9580.0
ART1	-12947.0
TLR2	-15735.0

---

Disorders of Developmental Biology

Disorders of Developmental Biology

	339
set	Disorders of Developmental Biology
setSize	11
pANOVA	0.0012
s.dist	-0.564
p.adjustANOVA	0.00317

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BDNF	-21779
SIN3A	-21372
CAMK4	-20926
CALM1	-20409
HDAC3	-20063
PRKACA	-17536
HDAC1	-15992
GPS2	-15678
TBL1XR1	-15286
NCOR1	-9368
NCOR2	-3684

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BDNF	-21779
SIN3A	-21372
CAMK4	-20926
CALM1	-20409
HDAC3	-20063
PRKACA	-17536
HDAC1	-15992
GPS2	-15678
TBL1XR1	-15286
NCOR1	-9368
NCOR2	-3684

---

Disorders of Nervous System Development

Disorders of Nervous System Development

	340
set	Disorders of Nervous System Development
setSize	11
pANOVA	0.0012
s.dist	-0.564
p.adjustANOVA	0.00317

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BDNF	-21779
SIN3A	-21372
CAMK4	-20926
CALM1	-20409
HDAC3	-20063
PRKACA	-17536
HDAC1	-15992
GPS2	-15678
TBL1XR1	-15286
NCOR1	-9368
NCOR2	-3684

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BDNF	-21779
SIN3A	-21372
CAMK4	-20926
CALM1	-20409
HDAC3	-20063
PRKACA	-17536
HDAC1	-15992
GPS2	-15678
TBL1XR1	-15286
NCOR1	-9368
NCOR2	-3684

---

Loss of function of MECP2 in Rett syndrome

Loss of function of MECP2 in Rett syndrome

	676
set	Loss of function of MECP2 in Rett syndrome
setSize	11
pANOVA	0.0012
s.dist	-0.564
p.adjustANOVA	0.00317

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BDNF	-21779
SIN3A	-21372
CAMK4	-20926
CALM1	-20409
HDAC3	-20063
PRKACA	-17536
HDAC1	-15992
GPS2	-15678
TBL1XR1	-15286
NCOR1	-9368
NCOR2	-3684

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BDNF	-21779
SIN3A	-21372
CAMK4	-20926
CALM1	-20409
HDAC3	-20063
PRKACA	-17536
HDAC1	-15992
GPS2	-15678
TBL1XR1	-15286
NCOR1	-9368
NCOR2	-3684

---

Pervasive developmental disorders

Pervasive developmental disorders

	902
set	Pervasive developmental disorders
setSize	11
pANOVA	0.0012
s.dist	-0.564
p.adjustANOVA	0.00317

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BDNF	-21779
SIN3A	-21372
CAMK4	-20926
CALM1	-20409
HDAC3	-20063
PRKACA	-17536
HDAC1	-15992
GPS2	-15678
TBL1XR1	-15286
NCOR1	-9368
NCOR2	-3684

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BDNF	-21779
SIN3A	-21372
CAMK4	-20926
CALM1	-20409
HDAC3	-20063
PRKACA	-17536
HDAC1	-15992
GPS2	-15678
TBL1XR1	-15286
NCOR1	-9368
NCOR2	-3684

---

Processing of Capped Intronless Pre-mRNA

Processing of Capped Intronless Pre-mRNA

	953
set	Processing of Capped Intronless Pre-mRNA
setSize	28
pANOVA	2.76e-07
s.dist	-0.561
p.adjustANOVA	2.03e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-22145
LSM11	-21620
PAPOLA	-21456
CPSF2	-21426
CSTF3	-21221
CPSF3	-21122
CLP1	-20845
SNRPG	-20461
SNRPD3	-20352
CSTF1	-20351
CPSF4	-19721
SLBP	-19567
SNRPF	-19234
FIP1L1	-19191
LSM10	-18878
SYMPK	-18128
NUDT21	-17457
PCF11	-16163
CPSF6	-15885
NCBP2	-15174

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-22145
LSM11	-21620
PAPOLA	-21456
CPSF2	-21426
CSTF3	-21221
CPSF3	-21122
CLP1	-20845
SNRPG	-20461
SNRPD3	-20352
CSTF1	-20351
CPSF4	-19721
SLBP	-19567
SNRPF	-19234
FIP1L1	-19191
LSM10	-18878
SYMPK	-18128
NUDT21	-17457
PCF11	-16163
CPSF6	-15885
NCBP2	-15174
WDR33	-14523
CPSF7	-14212
CPSF1	-14065
ZNF473	-13719
CSTF2T	-8314
SNRPE	-3237
PABPN1	-2129
SNRPB	-1655

---

Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade

	119
set	Beta-catenin phosphorylation cascade
setSize	16
pANOVA	0.000132
s.dist	-0.552
p.adjustANOVA	0.000464

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FRAT2	-21615
FRAT1	-21410
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FRAT2	-21615
FRAT1	-21410
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

RAF-independent MAPK1/3 activation

RAF-independent MAPK1/3 activation

	984
set	RAF-independent MAPK1/3 activation
setSize	22
pANOVA	7.82e-06
s.dist	-0.55
p.adjustANOVA	3.84e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DUSP6	-21834
JAK1	-21317
DUSP4	-21223
DUSP1	-21175
DUSP7	-20664
DUSP2	-19905
DUSP8	-19674
IL6R	-19645
DUSP16	-19476
CDK1	-18399
IL6ST	-18335
MAP2K2	-16616
TYK2	-16520
DUSP10	-16402
PEA15	-15888
DUSP5	-15176
PTPN11	-14775
MAP2K1	-14264
JAK2	-11382
MAPK1	-9185

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DUSP6	-21834.0
JAK1	-21317.0
DUSP4	-21223.0
DUSP1	-21175.0
DUSP7	-20664.0
DUSP2	-19905.0
DUSP8	-19674.0
IL6R	-19645.0
DUSP16	-19476.0
CDK1	-18399.0
IL6ST	-18335.0
MAP2K2	-16616.0
TYK2	-16520.0
DUSP10	-16402.0
PEA15	-15888.0
DUSP5	-15176.0
PTPN11	-14775.0
MAP2K1	-14264.0
JAK2	-11382.0
MAPK1	-9185.0
MAPK3	-8356.0
IL6	0.5

---

Regulated proteolysis of p75NTR

Regulated proteolysis of p75NTR

	1069
set	Regulated proteolysis of p75NTR
setSize	11
pANOVA	0.00181
s.dist	-0.543
p.adjustANOVA	0.00448

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRAF6	-20251
PSENEN	-19973
NCSTN	-19875
ADAM17	-19687
NGFR	-19085
PSEN2	-15833
APH1A	-14503
PSEN1	-14280
APH1B	-12418
NFKB1	-11658
RELA	-11539

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRAF6	-20251
PSENEN	-19973
NCSTN	-19875
ADAM17	-19687
NGFR	-19085
PSEN2	-15833
APH1A	-14503
PSEN1	-14280
APH1B	-12418
NFKB1	-11658
RELA	-11539

---

Repression of WNT target genes

Repression of WNT target genes

	1124
set	Repression of WNT target genes
setSize	13
pANOVA	0.000778
s.dist	-0.538
p.adjustANOVA	0.00219

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TCF7	-22213
MYC	-21888
TLE3	-20288
AXIN2	-20005
LEF1	-18398
TLE4	-16091
HDAC1	-15992
TLE1	-15645
CTBP2	-15136
TCF7L1	-14970
TLE2	-14637
TCF7L2	-9906
CTBP1	-5649

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TCF7	-22213
MYC	-21888
TLE3	-20288
AXIN2	-20005
LEF1	-18398
TLE4	-16091
HDAC1	-15992
TLE1	-15645
CTBP2	-15136
TCF7L1	-14970
TLE2	-14637
TCF7L2	-9906
CTBP1	-5649

---

FGFR2 alternative splicing

FGFR2 alternative splicing

	413
set	FGFR2 alternative splicing
setSize	26
pANOVA	2.9e-06
s.dist	-0.53
p.adjustANOVA	1.63e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-22145
HNRNPF	-22105
POLR2D	-21565
POLR2L	-20692
POLR2A	-20644
GTF2F1	-20169
POLR2I	-20007
HNRNPH1	-19411
POLR2F	-19214
ESRP2	-19202
POLR2C	-17687
POLR2B	-17590
POLR2G	-16833
TIA1	-16681
ESRP1	-15439
GTF2F2	-15226
NCBP2	-15174
TIAL1	-14231
POLR2H	-13846
RBFOX2	-12666

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-22145
HNRNPF	-22105
POLR2D	-21565
POLR2L	-20692
POLR2A	-20644
GTF2F1	-20169
POLR2I	-20007
HNRNPH1	-19411
POLR2F	-19214
ESRP2	-19202
POLR2C	-17687
POLR2B	-17590
POLR2G	-16833
TIA1	-16681
ESRP1	-15439
GTF2F2	-15226
NCBP2	-15174
TIAL1	-14231
POLR2H	-13846
RBFOX2	-12666
HNRNPM	-11734
HNRNPA1	-11547
POLR2K	-9985
PTBP1	-9937
POLR2E	-7880
POLR2J	-7102

---

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

	1167
set	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize	11
pANOVA	0.00272
s.dist	-0.522
p.adjustANOVA	0.00638

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-22145
LSM11	-21620
SNRPG	-20461
SNRPD3	-20352
SLBP	-19567
SNRPF	-19234
LSM10	-18878
NCBP2	-15174
ZNF473	-13719
SNRPE	-3237
SNRPB	-1655

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-22145
LSM11	-21620
SNRPG	-20461
SNRPD3	-20352
SLBP	-19567
SNRPF	-19234
LSM10	-18878
NCBP2	-15174
ZNF473	-13719
SNRPE	-3237
SNRPB	-1655

---

SUMOylation of immune response proteins

SUMOylation of immune response proteins

	1183
set	SUMOylation of immune response proteins
setSize	10
pANOVA	0.00434
s.dist	-0.521
p.adjustANOVA	0.00955

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NFKB2	-21140
NFKBIA	-20209
PIAS3	-19795
TOPORS	-17296
SUMO1	-15431
UBE2I	-14570
SUMO3	-14443
IKBKE	-13322
PIAS4	-12167
RELA	-11539

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NFKB2	-21140
NFKBIA	-20209
PIAS3	-19795
TOPORS	-17296
SUMO1	-15431
UBE2I	-14570
SUMO3	-14443
IKBKE	-13322
PIAS4	-12167
RELA	-11539

---

ERKs are inactivated

ERKs are inactivated

	375
set	ERKs are inactivated
setSize	13
pANOVA	0.00116
s.dist	-0.52
p.adjustANOVA	0.00312

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPK7	-22097
DUSP6	-21834
DUSP4	-21223
PPP2R5D	-21023
PPP2R1A	-20909
DUSP7	-20664
PPP2CA	-20652
VRK3	-15852
PPP2R1B	-15809
DUSP3	-11812
MAPK1	-9185
MAPK3	-8356
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPK7	-22097
DUSP6	-21834
DUSP4	-21223
PPP2R5D	-21023
PPP2R1A	-20909
DUSP7	-20664
PPP2CA	-20652
VRK3	-15852
PPP2R1B	-15809
DUSP3	-11812
MAPK1	-9185
MAPK3	-8356
PPP2CB	1675

---

Activation of the TFAP2 (AP-2) family of transcription factors

Activation of the TFAP2 (AP-2) family of transcription factors

	54
set	Activation of the TFAP2 (AP-2) family of transcription factors
setSize	11
pANOVA	0.00328
s.dist	-0.512
p.adjustANOVA	0.00755

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TFAP2A	-21188
CITED4	-20965
CITED2	-19264
TFAP2B	-19263
TFAP2E	-19061
CREBBP	-15528
YEATS4	-15330
TFAP2C	-14302
TFAP2D	-14027
EP300	-11115
WWOX	-4557

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TFAP2A	-21188
CITED4	-20965
CITED2	-19264
TFAP2B	-19263
TFAP2E	-19061
CREBBP	-15528
YEATS4	-15330
TFAP2C	-14302
TFAP2D	-14027
EP300	-11115
WWOX	-4557

---

Transcriptional regulation of testis differentiation

Transcriptional regulation of testis differentiation

	1426
set	Transcriptional regulation of testis differentiation
setSize	12
pANOVA	0.00224
s.dist	-0.509
p.adjustANOVA	0.00544

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FOXL2	-22183
WT1	-22086
GATA4	-20955
SOX9	-20877
FGF9	-19722
DHH	-17666
DMRT1	-17463
ZFPM2	-13176
AMH	-12214
WNT4	-10298
PTGDS	-9025
NR5A1	-4424

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FOXL2	-22183
WT1	-22086
GATA4	-20955
SOX9	-20877
FGF9	-19722
DHH	-17666
DMRT1	-17463
ZFPM2	-13176
AMH	-12214
WNT4	-10298
PTGDS	-9025
NR5A1	-4424

---

NGF-stimulated transcription

NGF-stimulated transcription

	773
set	NGF-stimulated transcription
setSize	39
pANOVA	4.08e-08
s.dist	-0.507
p.adjustANOVA	3.8e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDK5R2	-22160
VGF	-22007
ASCL1	-21869
EGR3	-21700
EGR1	-21370
ID2	-21170
JUNB	-21087
ID1	-20758
FOS	-20629
F3	-20529
CDK5	-20436
FOSB	-20155
ID4	-20059
FOSL1	-19636
EGR4	-19407
DNM2	-19186
SRF	-18743
TF	-18632
REST	-18384
JUND	-18359

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDK5R2	-22160
VGF	-22007
ASCL1	-21869
EGR3	-21700
EGR1	-21370
ID2	-21170
JUNB	-21087
ID1	-20758
FOS	-20629
F3	-20529
CDK5	-20436
FOSB	-20155
ID4	-20059
FOSL1	-19636
EGR4	-19407
DNM2	-19186
SRF	-18743
TF	-18632
REST	-18384
JUND	-18359
EGR2	-17520
NAB2	-16602
CDK5R1	-15822
TCF12	-15721
SH3GL3	-14686
LYL1	-13639
RRAD	-13492
NAB1	-11849
ID3	-11542
ARC	-11280
EP300	-11115
ATF2	-10719
SGK1	-10181
TRIB1	-9247
CREB1	-8121
ATF1	-6927
TPH1	-6091
MEF2D	-3202
CHD4	-2557

---

Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors

	399
set	Expression and translocation of olfactory receptors
setSize	365
pANOVA	1.2e-62
s.dist	0.507
p.adjustANOVA	3.66e-60

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR4M2	3836
OR2AG1	3797
OR1J4	3720
OR2Z1	3716
OR2D2	3692
OR7E24	3680
OR2AG2	3668
OR6K3	3615
OR7C1	3605
OR8H2	3530
OR4N2	3499
OR4C46	3497
OR5H2	3492
OR2A5	3482
OR11H4	3471
OR6B2	3458
OR51A7	3429
OR8B8	3424
OR9I1	3418
OR2J3	3407

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR4M2	3836.0
OR2AG1	3797.0
OR1J4	3720.0
OR2Z1	3716.0
OR2D2	3692.0
OR7E24	3680.0
OR2AG2	3668.0
OR6K3	3615.0
OR7C1	3605.0
OR8H2	3530.0
OR4N2	3499.0
OR4C46	3497.0
OR5H2	3492.0
OR2A5	3482.0
OR11H4	3471.0
OR6B2	3458.0
OR51A7	3429.0
OR8B8	3424.0
OR9I1	3418.0
OR2J3	3407.0
OR7D2	3398.0
OR56A4	3388.0
OR5P2	3386.0
OR7G1	3361.0
OR4C16	3351.0
OR56B4	3334.0
OR7A10	3321.0
OR6V1	3312.0
OR10Q1	3266.0
OR5A2	3191.0
OR52E6	3185.0
OR10G8	3162.0
OR5M3	3159.0
OR2T33	3126.0
OR1E1	3114.0
OR4A15	3079.0
OR10H3	3043.0
OR4A47	3035.0
OR52I2	3029.0
OR4K13	3017.0
OR4E2	2997.0
OR4N5	2995.0
OR11H6	2987.0
OR2C1	2915.0
OR9Q1	2900.0
OR12D2	2897.0
OR8K1	2892.0
OR51T1	2828.0
OR5B2	2817.0
OR1B1	2800.0
OR9A2	2747.0
OR1D2	2732.0
OR5AS1	2700.0
OR9Q2	2674.0
OR13C9	2630.0
OR5M8	2623.0
OR2B2	2600.0
OR4C6	2550.0
RTP1	2526.0
OR13C8	2525.0
OR7A17	2485.0
OR10K1	2472.0
OR6C3	2450.0
OR10G7	2370.0
OR7C2	2359.0
OR2L8	2284.0
OR1N1	2243.0
OR8H3	2199.0
OR56A3	2193.0
OR1I1	2170.0
OR5A1	2120.0
OR4C15	2088.0
OR10V1	1991.0
OR2L2	1940.0
OR6A2	1877.0
OR2AE1	1870.0
OR10G2	1852.0
OR52E8	1809.0
OR6B3	1761.0
OR2T29	1710.0
OR10G3	1629.0
OR52K2	1597.0
OR6K6	1525.0
OR52L1	1389.0
OR11A1	1339.0
OR2T4	1333.0
OR4K1	1324.0
OR6C68	1095.0
OR5T1	0.5
OR2S2	0.5
OR2AT4	0.5
OR1F1	0.5
OR5H1	0.5
OR2V2	0.5
OR2A25	0.5
OR8H1	0.5
OR2T2	0.5
OR4A5	0.5
OR8I2	0.5
OR10J1	0.5
OR56A1	0.5
OR2A14	0.5
OR5T2	0.5
OR6C75	0.5
OR6N1	0.5
OR5H6	0.5
OR9G4	0.5
OR10X1	0.5
OR5K1	0.5
OR2AP1	0.5
OR7G3	0.5
OR5AR1	0.5
OR2A2	0.5
OR8J1	0.5
OR5D16	0.5
OR2T35	0.5
OR4S1	0.5
OR4K15	0.5
OR6C1	0.5
OR8K3	0.5
OR6C6	0.5
OR4N4	0.5
OR5AN1	0.5
OR2A4	0.5
OR5J2	0.5
OR2G3	0.5
OR51G2	0.5
OR10AG1	0.5
OR2T5	0.5
OR5H14	0.5
OR5D13	0.5
OR1L3	0.5
OR52N4	0.5
OR4C12	0.5
OR4D5	0.5
OR5B3	0.5
OR8G2	0.5
OR13D1	0.5
OR52A5	0.5
OR2K2	0.5
OR2B3	0.5
OR13C4	0.5
OR52E4	0.5
OR52N2	0.5
OR5M11	0.5
OR6C65	0.5
OR51G1	0.5
OR13C2	0.5
OR13G1	0.5
OR5T3	0.5
OR2AK2	0.5
OR4X2	0.5
OR10A2	0.5
OR5L1	0.5
OR4F4	0.5
OR51F1	0.5
OR5C1	0.5
OR8B3	0.5
OR4C45	0.5
OR5L2	0.5
OR1Q1	0.5
OR10T2	0.5
OR1L6	0.5
OR10H4	0.5
OR6Q1	0.5
OR6N2	0.5
OR2A1	0.5
OR1L4	0.5
OR10R2	0.5
OR5M9	0.5
OR7D4	0.5
OR2L5	0.5
OR4K14	0.5
OR52N5	0.5
OR1D5	0.5
OR1D4	0.5
OR5AK2	0.5
OR4C13	0.5
OR4F5	-1064.0
OR5I1	-1074.0
OR1K1	-1079.0
RTP2	-1145.0
OR2Y1	-1146.0
OR10J5	-1224.0
OR2L3	-1284.0
OR10G9	-1300.0
OR10J3	-1336.0
OR51V1	-1421.0
OR13J1	-1436.0
OR2M5	-1443.0
OR8U8	-1498.0
OR1S2	-1557.0
OR2J2	-1634.0
OR1L1	-1687.0
OR7G2	-1789.0
OR52N1	-1806.0
OR6F1	-1848.0
OR8A1	-1890.0
OR51F2	-1906.0
OR4F6	-1923.0
OR4X1	-1925.0
OR10K2	-1948.0
OR1E2	-1964.0
OR52B6	-1970.0
OR2M2	-1983.0
OR6S1	-2013.0
OR52J3	-2062.0
OR4A16	-2074.0
OR10H2	-2183.0
OR51B2	-2184.0
OR9A4	-2198.0
OR10H1	-2243.0
OR10H5	-2314.0
OR2C3	-2442.0
OR8D1	-2471.0
OR4D10	-2668.0
OR1G1	-2761.0
OR52A1	-2790.0
OR3A3	-2797.0
OR51S1	-2842.0
OR2A12	-2945.0
OR6Y1	-3025.0
OR1N2	-3142.0
OR5V1	-3181.0
OR6T1	-3302.0
OR2M3	-3322.0
OR8B4	-3391.0
OR5AU1	-3433.0
OR10AD1	-3496.0
OR10A6	-3515.0
OR4D2	-3581.0
OR14J1	-3585.0
OR6M1	-3641.0
OR6B1	-3747.0
OR8K5	-3756.0
OR51D1	-3788.0
OR14I1	-3804.0
OR2V1	-3902.0
OR51I1	-3932.0
OR2G2	-3980.0
OR4D11	-3981.0
OR14C36	-3992.0
OR4Q3	-4010.0
OR6C4	-4012.0
OR2L13	-4041.0
OR2M7	-4331.0
OR5M10	-4443.0
OR4D9	-4766.0
OR9K2	-4851.0
OR7A5	-4925.0
OR5B21	-4946.0
OR52D1	-4989.0
OR10A4	-5027.0
OR5K3	-5032.0
OR12D3	-5088.0
OR2G6	-5160.0
OR5P3	-5172.0
OR2F2	-5300.0
OR52H1	-5301.0
OR2T11	-5330.0
OR2D3	-5369.0
OR6C76	-5446.0
OR2T27	-5505.0
OR10Z1	-5595.0
OR1L8	-5601.0
OR1J2	-5706.0
OR51B6	-5789.0
OR56A5	-5814.0
OR52E2	-5861.0
OR2T12	-5988.0
OR2W3	-5996.0
OR8U1	-6062.0
OR13C3	-6072.0
OR1S1	-6077.0
OR4K2	-6136.0
OR52K1	-6160.0
OR5AP2	-6242.0
OR6K2	-6245.0
OR56B1	-6300.0
OR4L1	-6312.0
OR1A1	-6317.0
OR5D14	-6337.0
OR2W1	-6546.0
OR8J3	-6552.0
OR5AC2	-6651.0
OR2W5	-6673.0
OR6C70	-6693.0
OR3A1	-6785.0
OR8D2	-6872.0
OR2B11	-6929.0
OR4K5	-7018.0
OR5K4	-7048.0
OR5D18	-7060.0
OR8B2	-7153.0
OR51Q1	-7155.0
OR5R1	-7410.0
OR10S1	-7523.0
OR2B6	-7556.0
OR6C2	-7584.0
OR2T6	-7587.0
OR1A2	-7659.0
OR6P1	-7789.0
OR4B1	-7824.0
OR8B12	-7827.0
OR51E2	-7926.0
OR1C1	-7977.0
OR10A5	-8171.0
OR5B17	-8294.0
OR2T8	-8307.0
OR9G1	-8380.5
OR9G9	-8380.5
OR4F15	-8399.0
OR6C74	-8425.0
OR11G2	-8434.0
OR1J1	-8463.0
OR2T34	-8558.0
OR4D1	-8715.0
OR3A2	-8720.0
OR8D4	-8837.0
OR51L1	-8854.0
OR4K17	-8894.0
OR4D6	-8937.0
OR11L1	-9116.0
OR5F1	-9508.0
OR2H1	-9570.0
OR2T3	-9643.0
OR10A3	-9688.0
OR52I1	-9704.0
OR6X1	-9728.0
OR8S1	-9745.0
OR2F1	-9864.0
OR52B2	-9875.0
OR10P1	-9877.0
OR5W2	-9925.0
OR13F1	-10190.0
OR8G5	-10258.0
OR4M1	-10410.0
OR4C3	-10437.0
OR5B12	-10649.0
OR10C1	-10725.0
OR51E1	-10856.0
OR52R1	-11012.0
OR2H2	-11013.0
OR10W1	-11015.0
OR10A7	-11090.0
OR1M1	-11178.0
OR5K2	-11303.0
OR8G1	-11383.0
OR10G4	-11608.0
OR51B4	-11937.0
OR51A2	-12377.0
OR14A16	-12445.0
OR2M4	-12773.0
OR51M1	-13413.0
OR52M1	-13566.0
OR2T1	-13968.0
OR13A1	-14846.0
LHX2	-15278.0
OR5M1	-15322.0
OR52W1	-16032.0
OR51I2	-16351.0
OR51B5	-17482.0
EBF1	-18710.0
LDB1	-21453.0
REEP1	-21579.0

---

Antimicrobial peptides

Antimicrobial peptides

	85
set	Antimicrobial peptides
setSize	82
pANOVA	2.06e-15
s.dist	0.506
p.adjustANOVA	5.82e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RNASE7	3794.0
DEFB123	3768.0
LYZ	3698.0
HTN1	3652.0
DEFA1	3582.5
DEFB118	3552.0
DEFB133	3465.0
DEFB108B	3283.0
DEFA3	3257.0
TLR1	3203.0
DEFB107A	3180.5
DEFB125	3161.0
CTSG	3071.0
CCR2	3019.0
BPIFB6	2834.0
PI3	2802.0
DEFB132	2744.0
ELANE	2444.0
REG3G	2441.0
ITLN1	2423.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RNASE7	3794.0
DEFB123	3768.0
LYZ	3698.0
HTN1	3652.0
DEFA1	3582.5
DEFB118	3552.0
DEFB133	3465.0
DEFB108B	3283.0
DEFA3	3257.0
TLR1	3203.0
DEFB107A	3180.5
DEFB125	3161.0
CTSG	3071.0
CCR2	3019.0
BPIFB6	2834.0
PI3	2802.0
DEFB132	2744.0
ELANE	2444.0
REG3G	2441.0
ITLN1	2423.0
DEFB105A	2371.5
DEFB119	2113.0
SEMG1	2035.0
PRTN3	1797.0
CCR6	1702.0
DEFB1	1600.0
BPIFA2	1524.0
DEFA6	0.5
DEFB124	0.5
BPIFA1	0.5
S100A8	0.5
DEFB103A	0.5
RNASE3	0.5
DEFB113	0.5
REG3A	0.5
EPPIN	0.5
DEFB110	0.5
S100A9	-1048.0
PGLYRP2	-1169.0
DEFB115	-1287.0
DEFB135	-1288.0
DCD	-1289.0
PGLYRP3	-1397.0
DEFA4	-1517.0
SLC11A1	-1915.0
PRSS3	-1961.0
DEFB129	-2039.0
LCN2	-2102.0
DEFB116	-2165.0
GNLY	-2203.0
BPI	-2423.0
RNASE8	-2479.0
DEFB127	-2806.0
S100A7A	-3079.0
BPIFB4	-3087.0
DEFB134	-3602.0
DEFB131	-3603.0
RNASE6	-3855.0
DEFB121	-5345.0
DEFB104A	-5438.5
DEFA5	-5568.0
CD4	-5690.0
PGLYRP4	-5788.0
DEFB106A	-5880.5
DEFB126	-5934.0
DEFB114	-6212.0
CAMP	-6605.0
HTN3	-7242.0
BPIFB1	-7609.0
PLA2G2A	-7665.0
BPIFB2	-8913.0
S100A7	-9051.0
DEFB136	-9321.0
DEFB128	-9580.0
ATOX1	-12604.0
ART1	-12947.0
TLR2	-15735.0
LEAP2	-16369.0
LTF	-16767.0
CLU	-17593.0
PGLYRP1	-18113.0
CHGA	-20161.0

---

Glucocorticoid biosynthesis

Glucocorticoid biosynthesis

	511
set	Glucocorticoid biosynthesis
setSize	10
pANOVA	0.00573
s.dist	0.504
p.adjustANOVA	0.012

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HSD3B1	3702.0
CYP11B1	3058.0
HSD11B1	2037.0
HSD3B2	0.5
CYP17A1	-1050.0
POMC	-2050.0
SERPINA6	-2435.0
CYP21A2	-2443.0
CYP11B2	-6634.0
HSD11B2	-20117.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HSD3B1	3702.0
CYP11B1	3058.0
HSD11B1	2037.0
HSD3B2	0.5
CYP17A1	-1050.0
POMC	-2050.0
SERPINA6	-2435.0
CYP21A2	-2443.0
CYP11B2	-6634.0
HSD11B2	-20117.0

---

Signaling by FGFR2 IIIa TM

Signaling by FGFR2 IIIa TM

	1240
set	Signaling by FGFR2 IIIa TM
setSize	19
pANOVA	0.000176
s.dist	-0.497
p.adjustANOVA	6e-04

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-22145
POLR2D	-21565
POLR2L	-20692
POLR2A	-20644
GTF2F1	-20169
POLR2I	-20007
POLR2F	-19214
POLR2C	-17687
POLR2B	-17590
POLR2G	-16833
GTF2F2	-15226
NCBP2	-15174
POLR2H	-13846
FGF1	-11572
FGF2	-10419
FGFR2	-10130
POLR2K	-9985
POLR2E	-7880
POLR2J	-7102

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-22145
POLR2D	-21565
POLR2L	-20692
POLR2A	-20644
GTF2F1	-20169
POLR2I	-20007
POLR2F	-19214
POLR2C	-17687
POLR2B	-17590
POLR2G	-16833
GTF2F2	-15226
NCBP2	-15174
POLR2H	-13846
FGF1	-11572
FGF2	-10419
FGFR2	-10130
POLR2K	-9985
POLR2E	-7880
POLR2J	-7102

---

Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes

	227
set	Condensation of Prometaphase Chromosomes
setSize	11
pANOVA	0.00437
s.dist	-0.496
p.adjustANOVA	0.00958

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSNK2B	-22234
NCAPG	-20696
SMC4	-19837
CDK1	-18399
CCNB2	-18212
NCAPH	-16938
SMC2	-14216
CCNB1	-12251
CSNK2A2	-11220
CSNK2A1	-10229
NCAPD2	-8131

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSNK2B	-22234
NCAPG	-20696
SMC4	-19837
CDK1	-18399
CCNB2	-18212
NCAPH	-16938
SMC2	-14216
CCNB1	-12251
CSNK2A2	-11220
CSNK2A1	-10229
NCAPD2	-8131

---

CTNNB1 S33 mutants aren’t phosphorylated

CTNNB1 S33 mutants aren’t phosphorylated

	153
set	CTNNB1 S33 mutants aren’t phosphorylated
setSize	14
pANOVA	0.00132
s.dist	-0.496
p.adjustANOVA	0.00342

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

CTNNB1 S37 mutants aren’t phosphorylated

CTNNB1 S37 mutants aren’t phosphorylated

	154
set	CTNNB1 S37 mutants aren’t phosphorylated
setSize	14
pANOVA	0.00132
s.dist	-0.496
p.adjustANOVA	0.00342

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

CTNNB1 S45 mutants aren’t phosphorylated

CTNNB1 S45 mutants aren’t phosphorylated

	155
set	CTNNB1 S45 mutants aren’t phosphorylated
setSize	14
pANOVA	0.00132
s.dist	-0.496
p.adjustANOVA	0.00342

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

CTNNB1 T41 mutants aren’t phosphorylated

CTNNB1 T41 mutants aren’t phosphorylated

	156
set	CTNNB1 T41 mutants aren’t phosphorylated
setSize	14
pANOVA	0.00132
s.dist	-0.496
p.adjustANOVA	0.00342

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

Signaling by CTNNB1 phospho-site mutants

Signaling by CTNNB1 phospho-site mutants

	1224
set	Signaling by CTNNB1 phospho-site mutants
setSize	14
pANOVA	0.00132
s.dist	-0.496
p.adjustANOVA	0.00342

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

Signaling by GSK3beta mutants

Signaling by GSK3beta mutants

	1249
set	Signaling by GSK3beta mutants
setSize	14
pANOVA	0.00132
s.dist	-0.496
p.adjustANOVA	0.00342

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
CTNNB1	-17620
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

Digestion of dietary carbohydrate

Digestion of dietary carbohydrate

	318
set	Digestion of dietary carbohydrate
setSize	10
pANOVA	0.00673
s.dist	0.495
p.adjustANOVA	0.0138

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AMY1B	3650
AMY1C	3650
AMY1A	3650
AMY2A	3459
LCT	2322
CHIT1	-4378
CHIA	-5291
AMY2B	-9350
MGAM	-11927
TREH	-12979

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AMY1B	3650
AMY1C	3650
AMY1A	3650
AMY2A	3459
LCT	2322
CHIT1	-4378
CHIA	-5291
AMY2B	-9350
MGAM	-11927
TREH	-12979

---

SLBP independent Processing of Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs

	1168
set	SLBP independent Processing of Histone Pre-mRNAs
setSize	10
pANOVA	0.00676
s.dist	-0.494
p.adjustANOVA	0.0139

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-22145
LSM11	-21620
SNRPG	-20461
SNRPD3	-20352
SNRPF	-19234
LSM10	-18878
NCBP2	-15174
ZNF473	-13719
SNRPE	-3237
SNRPB	-1655

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-22145
LSM11	-21620
SNRPG	-20461
SNRPD3	-20352
SNRPF	-19234
LSM10	-18878
NCBP2	-15174
ZNF473	-13719
SNRPE	-3237
SNRPB	-1655

---

Initiation of Nuclear Envelope (NE) Reformation

Initiation of Nuclear Envelope (NE) Reformation

	600
set	Initiation of Nuclear Envelope (NE) Reformation
setSize	18
pANOVA	0.000282
s.dist	-0.494
p.adjustANOVA	0.000918

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R1A	-20909
PPP2CA	-20652
BANF1	-20633
LEMD2	-20584
KPNB1	-20357
CDK1	-18399
CCNB2	-18212
VRK1	-17336
SIRT2	-16896
LMNB1	-16188
ANKLE2	-14631
LMNA	-13794
LEMD3	-13229
CCNB1	-12251
PPP2R2A	-11512
VRK2	-11367
TMPO	-11347
LBR	-3256

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R1A	-20909
PPP2CA	-20652
BANF1	-20633
LEMD2	-20584
KPNB1	-20357
CDK1	-18399
CCNB2	-18212
VRK1	-17336
SIRT2	-16896
LMNB1	-16188
ANKLE2	-14631
LMNA	-13794
LEMD3	-13229
CCNB1	-12251
PPP2R2A	-11512
VRK2	-11367
TMPO	-11347
LBR	-3256

---

Inhibition of DNA recombination at telomere

Inhibition of DNA recombination at telomere

	596
set	Inhibition of DNA recombination at telomere
setSize	20
pANOVA	0.000131
s.dist	-0.494
p.adjustANOVA	0.000459

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2D	-21565.0
TERF2IP	-20967.0
POLR2L	-20692.0
POLR2A	-20644.0
POLR2I	-20007.0
H2AFX	-19372.0
POLR2F	-19214.0
TINF2	-18348.0
POLR2C	-17687.0
POLR2B	-17590.0
POLR2G	-16833.0
TERF1	-14978.0
ACD	-14709.5
POLR2H	-13846.0
DAXX	-13430.0
POT1	-12617.0
POLR2K	-9985.0
POLR2E	-7880.0
POLR2J	-7102.0
TERF2	-5281.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2D	-21565.0
TERF2IP	-20967.0
POLR2L	-20692.0
POLR2A	-20644.0
POLR2I	-20007.0
H2AFX	-19372.0
POLR2F	-19214.0
TINF2	-18348.0
POLR2C	-17687.0
POLR2B	-17590.0
POLR2G	-16833.0
TERF1	-14978.0
ACD	-14709.5
POLR2H	-13846.0
DAXX	-13430.0
POT1	-12617.0
POLR2K	-9985.0
POLR2E	-7880.0
POLR2J	-7102.0
TERF2	-5281.0

---

RNA Polymerase III Transcription Termination

RNA Polymerase III Transcription Termination

	1039
set	RNA Polymerase III Transcription Termination
setSize	23
pANOVA	4.35e-05
s.dist	-0.492
p.adjustANOVA	0.000175

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NFIX	-22210
POLR1D	-22055
POLR3C	-20853
POLR2L	-20692
POLR3G	-20643
POLR3GL	-19690
NFIA	-19599
POLR3D	-19443
POLR2F	-19214
POLR3E	-18965
SSB	-18425
POLR3F	-16840
POLR1C	-16628
POLR3A	-15105
POLR3B	-14499
POLR3K	-14300
POLR2H	-13846
NFIC	-10293
POLR2K	-9985
NFIB	-9533

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NFIX	-22210
POLR1D	-22055
POLR3C	-20853
POLR2L	-20692
POLR3G	-20643
POLR3GL	-19690
NFIA	-19599
POLR3D	-19443
POLR2F	-19214
POLR3E	-18965
SSB	-18425
POLR3F	-16840
POLR1C	-16628
POLR3A	-15105
POLR3B	-14499
POLR3K	-14300
POLR2H	-13846
NFIC	-10293
POLR2K	-9985
NFIB	-9533
POLR2E	-7880
CRCP	-4485
POLR3H	-3953

---

Olfactory Signaling Pathway

Olfactory Signaling Pathway

	846
set	Olfactory Signaling Pathway
setSize	372
pANOVA	4.29e-60
s.dist	0.492
p.adjustANOVA	9.36e-58

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR4M2	3836
OR2AG1	3797
OR1J4	3720
OR2Z1	3716
OR2D2	3692
OR7E24	3680
OR2AG2	3668
OR6K3	3615
OR7C1	3605
OR8H2	3530
OR4N2	3499
OR4C46	3497
OR5H2	3492
OR2A5	3482
OR11H4	3471
OR6B2	3458
OR51A7	3429
OR8B8	3424
OR9I1	3418
OR2J3	3407

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR4M2	3836.0
OR2AG1	3797.0
OR1J4	3720.0
OR2Z1	3716.0
OR2D2	3692.0
OR7E24	3680.0
OR2AG2	3668.0
OR6K3	3615.0
OR7C1	3605.0
OR8H2	3530.0
OR4N2	3499.0
OR4C46	3497.0
OR5H2	3492.0
OR2A5	3482.0
OR11H4	3471.0
OR6B2	3458.0
OR51A7	3429.0
OR8B8	3424.0
OR9I1	3418.0
OR2J3	3407.0
OR7D2	3398.0
OR56A4	3388.0
OR5P2	3386.0
OR7G1	3361.0
OR4C16	3351.0
OR56B4	3334.0
OR7A10	3321.0
OR6V1	3312.0
OR10Q1	3266.0
OR5A2	3191.0
OR52E6	3185.0
OR10G8	3162.0
OR5M3	3159.0
OR2T33	3126.0
OR1E1	3114.0
OR4A15	3079.0
OR10H3	3043.0
OR4A47	3035.0
OR52I2	3029.0
OR4K13	3017.0
OR4E2	2997.0
OR4N5	2995.0
OR11H6	2987.0
OR2C1	2915.0
OR9Q1	2900.0
OR12D2	2897.0
OR8K1	2892.0
OR51T1	2828.0
OR5B2	2817.0
OR1B1	2800.0
OR9A2	2747.0
OR1D2	2732.0
OR5AS1	2700.0
OR9Q2	2674.0
OR13C9	2630.0
OR5M8	2623.0
OR2B2	2600.0
OR4C6	2550.0
RTP1	2526.0
OR13C8	2525.0
OR7A17	2485.0
OR10K1	2472.0
OR6C3	2450.0
OR10G7	2370.0
OR7C2	2359.0
OR2L8	2284.0
OR1N1	2243.0
OR8H3	2199.0
OR56A3	2193.0
OR1I1	2170.0
OR5A1	2120.0
OR4C15	2088.0
OR10V1	1991.0
OR2L2	1940.0
OR6A2	1877.0
OR2AE1	1870.0
OR10G2	1852.0
OR52E8	1809.0
OR6B3	1761.0
OR2T29	1710.0
OR10G3	1629.0
OR52K2	1597.0
OR6K6	1525.0
OR52L1	1389.0
OR11A1	1339.0
OR2T4	1333.0
OR4K1	1324.0
OR6C68	1095.0
OR5T1	0.5
OR2S2	0.5
OR2AT4	0.5
OR1F1	0.5
OR5H1	0.5
OR2V2	0.5
OR2A25	0.5
OR8H1	0.5
OR2T2	0.5
OR4A5	0.5
OR8I2	0.5
OR10J1	0.5
OR56A1	0.5
OR2A14	0.5
OR5T2	0.5
OR6C75	0.5
OR6N1	0.5
OR5H6	0.5
OR9G4	0.5
OR10X1	0.5
OR5K1	0.5
OR2AP1	0.5
OR7G3	0.5
OR5AR1	0.5
OR2A2	0.5
OR8J1	0.5
OR5D16	0.5
OR2T35	0.5
OR4S1	0.5
OR4K15	0.5
OR6C1	0.5
OR8K3	0.5
OR6C6	0.5
OR4N4	0.5
OR5AN1	0.5
OR2A4	0.5
OR5J2	0.5
OR2G3	0.5
OR51G2	0.5
OR10AG1	0.5
OR2T5	0.5
OR5H14	0.5
OR5D13	0.5
OR1L3	0.5
OR52N4	0.5
OR4C12	0.5
OR4D5	0.5
OR5B3	0.5
OR8G2	0.5
OR13D1	0.5
OR52A5	0.5
OR2K2	0.5
OR2B3	0.5
OR13C4	0.5
OR52E4	0.5
OR52N2	0.5
OR5M11	0.5
OR6C65	0.5
OR51G1	0.5
OR13C2	0.5
OR13G1	0.5
OR5T3	0.5
OR2AK2	0.5
OR4X2	0.5
OR10A2	0.5
OR5L1	0.5
OR4F4	0.5
OR51F1	0.5
OR5C1	0.5
OR8B3	0.5
OR4C45	0.5
OR5L2	0.5
OR1Q1	0.5
OR10T2	0.5
OR1L6	0.5
OR10H4	0.5
OR6Q1	0.5
OR6N2	0.5
OR2A1	0.5
OR1L4	0.5
OR10R2	0.5
OR5M9	0.5
OR7D4	0.5
OR2L5	0.5
OR4K14	0.5
OR52N5	0.5
OR1D5	0.5
OR1D4	0.5
OR5AK2	0.5
OR4C13	0.5
OR4F5	-1064.0
OR5I1	-1074.0
OR1K1	-1079.0
RTP2	-1145.0
OR2Y1	-1146.0
OR10J5	-1224.0
OR2L3	-1284.0
OR10G9	-1300.0
OR10J3	-1336.0
OR51V1	-1421.0
OR13J1	-1436.0
OR2M5	-1443.0
OR8U8	-1498.0
OR1S2	-1557.0
OR2J2	-1634.0
OR1L1	-1687.0
OR7G2	-1789.0
OR52N1	-1806.0
OR6F1	-1848.0
OR8A1	-1890.0
OR51F2	-1906.0
OR4F6	-1923.0
OR4X1	-1925.0
OR10K2	-1948.0
OR1E2	-1964.0
OR52B6	-1970.0
OR2M2	-1983.0
OR6S1	-2013.0
OR52J3	-2062.0
OR4A16	-2074.0
OR10H2	-2183.0
OR51B2	-2184.0
OR9A4	-2198.0
OR10H1	-2243.0
OR10H5	-2314.0
OR2C3	-2442.0
OR8D1	-2471.0
OR4D10	-2668.0
OR1G1	-2761.0
OR52A1	-2790.0
OR3A3	-2797.0
OR51S1	-2842.0
OR2A12	-2945.0
OR6Y1	-3025.0
OR1N2	-3142.0
OR5V1	-3181.0
OR6T1	-3302.0
OR2M3	-3322.0
OR8B4	-3391.0
OR5AU1	-3433.0
OR10AD1	-3496.0
OR10A6	-3515.0
OR4D2	-3581.0
OR14J1	-3585.0
OR6M1	-3641.0
OR6B1	-3747.0
OR8K5	-3756.0
OR51D1	-3788.0
OR14I1	-3804.0
OR2V1	-3902.0
OR51I1	-3932.0
OR2G2	-3980.0
OR4D11	-3981.0
OR14C36	-3992.0
OR4Q3	-4010.0
OR6C4	-4012.0
OR2L13	-4041.0
OR2M7	-4331.0
OR5M10	-4443.0
OR4D9	-4766.0
OR9K2	-4851.0
OR7A5	-4925.0
OR5B21	-4946.0
OR52D1	-4989.0
OR10A4	-5027.0
OR5K3	-5032.0
OR12D3	-5088.0
OR2G6	-5160.0
OR5P3	-5172.0
OR2F2	-5300.0
OR52H1	-5301.0
OR2T11	-5330.0
OR2D3	-5369.0
OR6C76	-5446.0
OR2T27	-5505.0
OR10Z1	-5595.0
OR1L8	-5601.0
OR1J2	-5706.0
OR51B6	-5789.0
OR56A5	-5814.0
OR52E2	-5861.0
OR2T12	-5988.0
OR2W3	-5996.0
OR8U1	-6062.0
OR13C3	-6072.0
OR1S1	-6077.0
OR4K2	-6136.0
OR52K1	-6160.0
OR5AP2	-6242.0
OR6K2	-6245.0
OR56B1	-6300.0
OR4L1	-6312.0
OR1A1	-6317.0
OR5D14	-6337.0
OR2W1	-6546.0
OR8J3	-6552.0
OR5AC2	-6651.0
OR2W5	-6673.0
OR6C70	-6693.0
OR3A1	-6785.0
OR8D2	-6872.0
OR2B11	-6929.0
OR4K5	-7018.0
OR5K4	-7048.0
OR5D18	-7060.0
OR8B2	-7153.0
OR51Q1	-7155.0
OR5R1	-7410.0
OR10S1	-7523.0
OR2B6	-7556.0
OR6C2	-7584.0
OR2T6	-7587.0
OR1A2	-7659.0
OR6P1	-7789.0
OR4B1	-7824.0
OR8B12	-7827.0
OR51E2	-7926.0
OR1C1	-7977.0
OR10A5	-8171.0
OR5B17	-8294.0
OR2T8	-8307.0
OR9G1	-8380.5
OR9G9	-8380.5
OR4F15	-8399.0
OR6C74	-8425.0
OR11G2	-8434.0
OR1J1	-8463.0
OR2T34	-8558.0
OR4D1	-8715.0
OR3A2	-8720.0
OR8D4	-8837.0
OR51L1	-8854.0
OR4K17	-8894.0
OR4D6	-8937.0
OR11L1	-9116.0
OR5F1	-9508.0
GNB1	-9548.0
OR2H1	-9570.0
OR2T3	-9643.0
OR10A3	-9688.0
OR52I1	-9704.0
OR6X1	-9728.0
OR8S1	-9745.0
OR2F1	-9864.0
OR52B2	-9875.0
OR10P1	-9877.0
OR5W2	-9925.0
OR13F1	-10190.0
OR8G5	-10258.0
OR4M1	-10410.0
OR4C3	-10437.0
CNGA4	-10487.0
OR5B12	-10649.0
OR10C1	-10725.0
ADCY3	-10732.0
OR51E1	-10856.0
OR52R1	-11012.0
OR2H2	-11013.0
OR10W1	-11015.0
OR10A7	-11090.0
OR1M1	-11178.0
OR5K2	-11303.0
OR8G1	-11383.0
OR10G4	-11608.0
OR51B4	-11937.0
OR51A2	-12377.0
OR14A16	-12445.0
ANO2	-12490.0
OR2M4	-12773.0
GNG13	-13273.0
OR51M1	-13413.0
OR52M1	-13566.0
OR2T1	-13968.0
OR13A1	-14846.0
LHX2	-15278.0
OR5M1	-15322.0
OR52W1	-16032.0
OR51I2	-16351.0
CNGB1	-17105.0
OR51B5	-17482.0
EBF1	-18710.0
GNAL	-19071.0
LDB1	-21453.0
REEP1	-21579.0

---

ERK/MAPK targets

ERK/MAPK targets

	374
set	ERK/MAPK targets
setSize	20
pANOVA	0.000148
s.dist	-0.49
p.adjustANOVA	0.000512

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPK7	-22097
DUSP6	-21834
DUSP4	-21223
PPP2R5D	-21023
PPP2R1A	-20909
DUSP7	-20664
PPP2CA	-20652
MAPK14	-19827
RPS6KA5	-17153
MEF2A	-16911
MEF2C	-16262
VRK3	-15852
PPP2R1B	-15809
MAPK11	-14678
DUSP3	-11812
RPS6KA2	-11098
MAPK1	-9185
MAPK3	-8356
RPS6KA1	-8062
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPK7	-22097
DUSP6	-21834
DUSP4	-21223
PPP2R5D	-21023
PPP2R1A	-20909
DUSP7	-20664
PPP2CA	-20652
MAPK14	-19827
RPS6KA5	-17153
MEF2A	-16911
MEF2C	-16262
VRK3	-15852
PPP2R1B	-15809
MAPK11	-14678
DUSP3	-11812
RPS6KA2	-11098
MAPK1	-9185
MAPK3	-8356
RPS6KA1	-8062
PPP2CB	1675

---

APC truncation mutants have impaired AXIN binding

APC truncation mutants have impaired AXIN binding

	10
set	APC truncation mutants have impaired AXIN binding
setSize	13
pANOVA	0.0025
s.dist	-0.484
p.adjustANOVA	0.00593

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

AXIN missense mutants destabilize the destruction complex

AXIN missense mutants destabilize the destruction complex

	23
set	AXIN missense mutants destabilize the destruction complex
setSize	13
pANOVA	0.0025
s.dist	-0.484
p.adjustANOVA	0.00593

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

Signaling by AMER1 mutants

Signaling by AMER1 mutants

	1217
set	Signaling by AMER1 mutants
setSize	13
pANOVA	0.0025
s.dist	-0.484
p.adjustANOVA	0.00593

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

Signaling by APC mutants

Signaling by APC mutants

	1218
set	Signaling by APC mutants
setSize	13
pANOVA	0.0025
s.dist	-0.484
p.adjustANOVA	0.00593

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

Signaling by AXIN mutants

Signaling by AXIN mutants

	1219
set	Signaling by AXIN mutants
setSize	13
pANOVA	0.0025
s.dist	-0.484
p.adjustANOVA	0.00593

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

Truncations of AMER1 destabilize the destruction complex

Truncations of AMER1 destabilize the destruction complex

	1459
set	Truncations of AMER1 destabilize the destruction complex
setSize	13
pANOVA	0.0025
s.dist	-0.484
p.adjustANOVA	0.00593

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PPP2R5D	-21023
APC	-20929
PPP2R1A	-20909
PPP2CA	-20652
CSNK1A1	-19368
PPP2R5B	-19285
PPP2R5E	-17335
PPP2R1B	-15809
PPP2R5C	-15247
AXIN1	-12464
GSK3B	-10866
PPP2R5A	-9438
PPP2CB	1675

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report