Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2022-05-18
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## metric
## PTPRN2 18.35412
## ATP11A 25.57120
## DIP2C 17.74760
## MAD1L1 11.06716
## INPP5A 18.06203
## PCDHGA1 15.82281| Profile metrics | |
|---|---|
| num_genesets | 2546 |
| num_genes_in_profile | 26148 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 10252 |
| num_profile_genes_not_in_sets | 15896 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes.
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt| Gene sets metrics | |
|---|---|
| num_genesets | 2546 |
| num_genesets_excluded | 1018 |
| num_genesets_included | 1528 |
Differential pathway expression
Interactive enrichment scatterplot
Significance is calculated by -log10(p-value). All points shown are FDR<0.05.
Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.
Results table
Top N= 50 gene sets| set | setSize | pANOVA | s.dist | p.adjustANOVA |
|---|---|---|---|---|
| Digestion of dietary carbohydrate | 10 | 6.77e-04 | 0.621 | 4.02e-03 |
| Eukaryotic Translation Elongation | 88 | 8.18e-24 | -0.620 | 9.61e-22 |
| Peptide chain elongation | 84 | 2.15e-22 | -0.614 | 2.19e-20 |
| Viral mRNA Translation | 84 | 2.62e-22 | -0.612 | 2.50e-20 |
| SUMOylation of immune response proteins | 10 | 8.77e-04 | -0.607 | 5.02e-03 |
| Eukaryotic Translation Termination | 87 | 9.34e-22 | -0.594 | 7.93e-20 |
| Interaction With Cumulus Cells And The Zona Pellucida | 11 | 6.64e-04 | 0.593 | 3.96e-03 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 14 | 1.36e-04 | -0.589 | 1.01e-03 |
| Selenocysteine synthesis | 87 | 1.12e-20 | -0.578 | 6.86e-19 |
| Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 15 | 1.08e-04 | 0.577 | 8.21e-04 |
| DCC mediated attractive signaling | 14 | 1.93e-04 | 0.575 | 1.38e-03 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 95 | 4.94e-22 | -0.572 | 4.44e-20 |
| SRP-dependent cotranslational protein targeting to membrane | 105 | 3.69e-24 | -0.572 | 4.70e-22 |
| Formation of a pool of free 40S subunits | 95 | 5.45e-21 | -0.557 | 3.47e-19 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 89 | 2.28e-19 | -0.551 | 1.20e-17 |
| SARS-CoV-2 modulates host translation machinery | 46 | 2.58e-10 | -0.538 | 8.40e-09 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 105 | 1.69e-21 | -0.537 | 1.17e-19 |
| Recycling of bile acids and salts | 18 | 9.04e-05 | 0.533 | 6.94e-04 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 104 | 1.90e-20 | -0.525 | 1.11e-18 |
| Cap-dependent Translation Initiation | 112 | 1.21e-21 | -0.522 | 9.26e-20 |
| Eukaryotic Translation Initiation | 112 | 1.21e-21 | -0.522 | 9.26e-20 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 24 | 1.10e-05 | 0.518 | 1.06e-04 |
| Formation of the ternary complex, and subsequently, the 43S complex | 47 | 2.93e-09 | -0.500 | 7.72e-08 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | 39 | 7.16e-08 | 0.498 | 1.29e-06 |
| NGF-stimulated transcription | 39 | 1.01e-07 | -0.492 | 1.68e-06 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 108 | 2.54e-18 | -0.486 | 1.21e-16 |
| Nonsense-Mediated Decay (NMD) | 108 | 2.54e-18 | -0.486 | 1.21e-16 |
| Selenoamino acid metabolism | 103 | 1.60e-17 | -0.485 | 7.42e-16 |
| Activation of the phototransduction cascade | 11 | 5.64e-03 | 0.482 | 2.42e-02 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 171 | 1.34e-26 | -0.472 | 2.27e-24 |
| Influenza Viral RNA Transcription and Replication | 129 | 1.95e-20 | -0.472 | 1.11e-18 |
| POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 10 | 9.78e-03 | -0.472 | 3.86e-02 |
| SCF(Skp2)-mediated degradation of p27/p21 | 58 | 5.60e-10 | -0.470 | 1.78e-08 |
| Inhibition of DNA recombination at telomere | 20 | 2.70e-04 | -0.470 | 1.85e-03 |
| ERKs are inactivated | 13 | 3.38e-03 | -0.469 | 1.59e-02 |
| Ribosomal scanning and start codon recognition | 54 | 2.90e-09 | -0.467 | 7.72e-08 |
| rRNA processing in the nucleus and cytosol | 180 | 9.85e-27 | -0.462 | 1.88e-24 |
| Intrinsic Pathway of Fibrin Clot Formation | 21 | 2.68e-04 | 0.459 | 1.85e-03 |
| Regulation of expression of SLITs and ROBOs | 159 | 1.46e-23 | -0.459 | 1.59e-21 |
| Mitochondrial translation initiation | 87 | 2.04e-13 | -0.455 | 7.99e-12 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | 10 | 1.27e-02 | 0.455 | 4.77e-02 |
| Transcriptional regulation of testis differentiation | 12 | 6.47e-03 | -0.454 | 2.72e-02 |
| RNA Polymerase III Chain Elongation | 18 | 9.07e-04 | -0.452 | 5.17e-03 |
| Mitochondrial translation termination | 87 | 3.48e-13 | -0.451 | 1.33e-11 |
| rRNA processing | 186 | 4.30e-26 | -0.448 | 6.58e-24 |
| Folding of actin by CCT/TriC | 10 | 1.47e-02 | -0.445 | 5.31e-02 |
| Digestion and absorption | 26 | 8.58e-05 | 0.445 | 6.69e-04 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 55 | 1.17e-08 | -0.444 | 2.79e-07 |
| Mitochondrial translation | 93 | 1.27e-13 | -0.444 | 5.17e-12 |
| NRIF signals cell death from the nucleus | 16 | 2.11e-03 | -0.444 | 1.11e-02 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pANOVA | s.dist | p.adjustANOVA |
|---|---|---|---|---|
| Digestion of dietary carbohydrate | 10 | 6.77e-04 | 0.621000 | 4.02e-03 |
| Eukaryotic Translation Elongation | 88 | 8.18e-24 | -0.620000 | 9.61e-22 |
| Peptide chain elongation | 84 | 2.15e-22 | -0.614000 | 2.19e-20 |
| Viral mRNA Translation | 84 | 2.62e-22 | -0.612000 | 2.50e-20 |
| SUMOylation of immune response proteins | 10 | 8.77e-04 | -0.607000 | 5.02e-03 |
| Eukaryotic Translation Termination | 87 | 9.34e-22 | -0.594000 | 7.93e-20 |
| Interaction With Cumulus Cells And The Zona Pellucida | 11 | 6.64e-04 | 0.593000 | 3.96e-03 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 14 | 1.36e-04 | -0.589000 | 1.01e-03 |
| Selenocysteine synthesis | 87 | 1.12e-20 | -0.578000 | 6.86e-19 |
| Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 15 | 1.08e-04 | 0.577000 | 8.21e-04 |
| DCC mediated attractive signaling | 14 | 1.93e-04 | 0.575000 | 1.38e-03 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 95 | 4.94e-22 | -0.572000 | 4.44e-20 |
| SRP-dependent cotranslational protein targeting to membrane | 105 | 3.69e-24 | -0.572000 | 4.70e-22 |
| Formation of a pool of free 40S subunits | 95 | 5.45e-21 | -0.557000 | 3.47e-19 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 89 | 2.28e-19 | -0.551000 | 1.20e-17 |
| SARS-CoV-2 modulates host translation machinery | 46 | 2.58e-10 | -0.538000 | 8.40e-09 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 105 | 1.69e-21 | -0.537000 | 1.17e-19 |
| Recycling of bile acids and salts | 18 | 9.04e-05 | 0.533000 | 6.94e-04 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 104 | 1.90e-20 | -0.525000 | 1.11e-18 |
| Cap-dependent Translation Initiation | 112 | 1.21e-21 | -0.522000 | 9.26e-20 |
| Eukaryotic Translation Initiation | 112 | 1.21e-21 | -0.522000 | 9.26e-20 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 24 | 1.10e-05 | 0.518000 | 1.06e-04 |
| Formation of the ternary complex, and subsequently, the 43S complex | 47 | 2.93e-09 | -0.500000 | 7.72e-08 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | 39 | 7.16e-08 | 0.498000 | 1.29e-06 |
| NGF-stimulated transcription | 39 | 1.01e-07 | -0.492000 | 1.68e-06 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 108 | 2.54e-18 | -0.486000 | 1.21e-16 |
| Nonsense-Mediated Decay (NMD) | 108 | 2.54e-18 | -0.486000 | 1.21e-16 |
| Selenoamino acid metabolism | 103 | 1.60e-17 | -0.485000 | 7.42e-16 |
| Activation of the phototransduction cascade | 11 | 5.64e-03 | 0.482000 | 2.42e-02 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 171 | 1.34e-26 | -0.472000 | 2.27e-24 |
| Influenza Viral RNA Transcription and Replication | 129 | 1.95e-20 | -0.472000 | 1.11e-18 |
| POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 10 | 9.78e-03 | -0.472000 | 3.86e-02 |
| SCF(Skp2)-mediated degradation of p27/p21 | 58 | 5.60e-10 | -0.470000 | 1.78e-08 |
| Inhibition of DNA recombination at telomere | 20 | 2.70e-04 | -0.470000 | 1.85e-03 |
| ERKs are inactivated | 13 | 3.38e-03 | -0.469000 | 1.59e-02 |
| Ribosomal scanning and start codon recognition | 54 | 2.90e-09 | -0.467000 | 7.72e-08 |
| rRNA processing in the nucleus and cytosol | 180 | 9.85e-27 | -0.462000 | 1.88e-24 |
| Intrinsic Pathway of Fibrin Clot Formation | 21 | 2.68e-04 | 0.459000 | 1.85e-03 |
| Regulation of expression of SLITs and ROBOs | 159 | 1.46e-23 | -0.459000 | 1.59e-21 |
| Mitochondrial translation initiation | 87 | 2.04e-13 | -0.455000 | 7.99e-12 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | 10 | 1.27e-02 | 0.455000 | 4.77e-02 |
| Transcriptional regulation of testis differentiation | 12 | 6.47e-03 | -0.454000 | 2.72e-02 |
| RNA Polymerase III Chain Elongation | 18 | 9.07e-04 | -0.452000 | 5.17e-03 |
| Mitochondrial translation termination | 87 | 3.48e-13 | -0.451000 | 1.33e-11 |
| rRNA processing | 186 | 4.30e-26 | -0.448000 | 6.58e-24 |
| Folding of actin by CCT/TriC | 10 | 1.47e-02 | -0.445000 | 5.31e-02 |
| Digestion and absorption | 26 | 8.58e-05 | 0.445000 | 6.69e-04 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 55 | 1.17e-08 | -0.444000 | 2.79e-07 |
| Mitochondrial translation | 93 | 1.27e-13 | -0.444000 | 5.17e-12 |
| NRIF signals cell death from the nucleus | 16 | 2.11e-03 | -0.444000 | 1.11e-02 |
| Digestion | 21 | 4.31e-04 | 0.444000 | 2.80e-03 |
| Activation of RAC1 | 11 | 1.10e-02 | 0.442000 | 4.27e-02 |
| Translation | 263 | 3.39e-35 | -0.442000 | 1.73e-32 |
| Translation initiation complex formation | 54 | 1.99e-08 | -0.441000 | 4.53e-07 |
| cGMP effects | 15 | 3.12e-03 | 0.441000 | 1.49e-02 |
| Mitochondrial translation elongation | 87 | 1.64e-12 | -0.438000 | 5.82e-11 |
| Influenza Infection | 148 | 6.09e-20 | -0.435000 | 3.33e-18 |
| Response of EIF2AK1 (HRI) to heme deficiency | 14 | 4.99e-03 | -0.433000 | 2.14e-02 |
| Negative regulation of NOTCH4 signaling | 52 | 9.15e-08 | -0.428000 | 1.59e-06 |
| Cellular response to starvation | 147 | 4.84e-19 | -0.425000 | 2.46e-17 |
| Hh mutants are degraded by ERAD | 54 | 6.98e-08 | -0.424000 | 1.27e-06 |
| RUNX3 regulates p14-ARF | 10 | 2.20e-02 | -0.418000 | 7.15e-02 |
| Zinc influx into cells by the SLC39 gene family | 10 | 2.24e-02 | -0.417000 | 7.21e-02 |
| Hh mutants abrogate ligand secretion | 57 | 5.87e-08 | -0.415000 | 1.15e-06 |
| Heme degradation | 16 | 4.16e-03 | 0.414000 | 1.86e-02 |
| Pexophagy | 11 | 1.76e-02 | -0.413000 | 6.04e-02 |
| Nuclear Events (kinase and transcription factor activation) | 60 | 3.13e-08 | -0.413000 | 6.55e-07 |
| Aspirin ADME | 44 | 2.20e-06 | 0.412000 | 2.66e-05 |
| Regulation of RUNX3 expression and activity | 53 | 2.33e-07 | -0.410000 | 3.71e-06 |
| Endosomal/Vacuolar pathway | 12 | 1.40e-02 | -0.410000 | 5.16e-02 |
| KSRP (KHSRP) binds and destabilizes mRNA | 17 | 3.45e-03 | -0.410000 | 1.60e-02 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | 53 | 2.66e-07 | -0.408000 | 4.10e-06 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 50 | 6.71e-07 | -0.406000 | 9.76e-06 |
| Early Phase of HIV Life Cycle | 14 | 8.65e-03 | -0.405000 | 3.48e-02 |
| Androgen biosynthesis | 11 | 2.07e-02 | 0.403000 | 6.90e-02 |
| Ubiquitin-dependent degradation of Cyclin D | 50 | 8.22e-07 | -0.403000 | 1.17e-05 |
| Vpu mediated degradation of CD4 | 50 | 9.62e-07 | -0.400000 | 1.32e-05 |
| HIV elongation arrest and recovery | 29 | 1.96e-04 | -0.399000 | 1.39e-03 |
| Pausing and recovery of HIV elongation | 29 | 1.96e-04 | -0.399000 | 1.39e-03 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 71 | 5.94e-09 | -0.399000 | 1.51e-07 |
| Autodegradation of the E3 ubiquitin ligase COP1 | 50 | 1.06e-06 | -0.399000 | 1.45e-05 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 11 | 2.21e-02 | -0.399000 | 7.16e-02 |
| p75NTR recruits signalling complexes | 12 | 1.68e-02 | -0.398000 | 5.89e-02 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | 48 | 1.82e-06 | -0.398000 | 2.27e-05 |
| Bile acid and bile salt metabolism | 45 | 3.89e-06 | 0.398000 | 4.41e-05 |
| Base-Excision Repair, AP Site Formation | 18 | 3.50e-03 | -0.397000 | 1.60e-02 |
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | 12 | 1.72e-02 | -0.397000 | 5.95e-02 |
| Sensory perception of sweet, bitter, and umami (glutamate) taste | 41 | 1.13e-05 | 0.396000 | 1.08e-04 |
| Asymmetric localization of PCP proteins | 62 | 6.86e-08 | -0.396000 | 1.27e-06 |
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 50 | 1.29e-06 | -0.395000 | 1.68e-05 |
| p53-Independent DNA Damage Response | 50 | 1.29e-06 | -0.395000 | 1.68e-05 |
| p53-Independent G1/S DNA damage checkpoint | 50 | 1.29e-06 | -0.395000 | 1.68e-05 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 17 | 4.80e-03 | -0.395000 | 2.08e-02 |
| Condensation of Prometaphase Chromosomes | 11 | 2.37e-02 | -0.394000 | 7.44e-02 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 72 | 7.46e-09 | -0.394000 | 1.84e-07 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 17 | 4.96e-03 | -0.393000 | 2.14e-02 |
| p53-Dependent G1 DNA Damage Response | 64 | 5.42e-08 | -0.393000 | 1.09e-06 |
| p53-Dependent G1/S DNA damage checkpoint | 64 | 5.42e-08 | -0.393000 | 1.09e-06 |
| MET activates PTK2 signaling | 18 | 3.99e-03 | 0.392000 | 1.80e-02 |
| Autodegradation of Cdh1 by Cdh1:APC/C | 62 | 9.54e-08 | -0.392000 | 1.62e-06 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | 74 | 6.88e-09 | -0.389000 | 1.72e-07 |
| FGFR2 alternative splicing | 26 | 5.90e-04 | -0.389000 | 3.62e-03 |
| TICAM1-dependent activation of IRF3/IRF7 | 12 | 2.00e-02 | -0.388000 | 6.73e-02 |
| Synthesis of PIPs at the early endosome membrane | 15 | 9.40e-03 | 0.387000 | 3.74e-02 |
| CDK-mediated phosphorylation and removal of Cdc6 | 71 | 1.68e-08 | -0.387000 | 3.89e-07 |
| Pausing and recovery of Tat-mediated HIV elongation | 27 | 5.22e-04 | -0.386000 | 3.27e-03 |
| Tat-mediated HIV elongation arrest and recovery | 27 | 5.22e-04 | -0.386000 | 3.27e-03 |
| Vif-mediated degradation of APOBEC3G | 50 | 2.59e-06 | -0.384000 | 3.09e-05 |
| G1/S DNA Damage Checkpoints | 66 | 6.83e-08 | -0.384000 | 1.27e-06 |
| Adherens junctions interactions | 26 | 7.04e-04 | 0.384000 | 4.15e-03 |
| Glucuronidation | 25 | 9.22e-04 | 0.383000 | 5.24e-03 |
| Synthesis of PIPs at the late endosome membrane | 10 | 3.66e-02 | 0.382000 | 1.05e-01 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 75 | 1.15e-08 | -0.381000 | 2.79e-07 |
| APC/C:Cdc20 mediated degradation of Securin | 66 | 9.15e-08 | -0.380000 | 1.59e-06 |
| Prefoldin mediated transfer of substrate to CCT/TriC | 27 | 6.31e-04 | -0.380000 | 3.81e-03 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | 23 | 1.65e-03 | -0.379000 | 8.94e-03 |
| Degradation of AXIN | 53 | 1.82e-06 | -0.379000 | 2.27e-05 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 53 | 1.85e-06 | -0.378000 | 2.28e-05 |
| p75NTR signals via NF-kB | 15 | 1.12e-02 | -0.378000 | 4.31e-02 |
| Metabolism of polyamines | 55 | 1.25e-06 | -0.378000 | 1.66e-05 |
| Processing of Intronless Pre-mRNAs | 19 | 4.37e-03 | -0.378000 | 1.92e-02 |
| Interaction between L1 and Ankyrins | 28 | 5.57e-04 | 0.377000 | 3.45e-03 |
| Regulation of ornithine decarboxylase (ODC) | 49 | 5.03e-06 | -0.377000 | 5.53e-05 |
| mRNA Splicing - Minor Pathway | 53 | 2.15e-06 | -0.376000 | 2.63e-05 |
| Synthesis of bile acids and bile salts | 34 | 1.50e-04 | 0.375000 | 1.09e-03 |
| SCF-beta-TrCP mediated degradation of Emi1 | 53 | 2.24e-06 | -0.375000 | 2.69e-05 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | 10 | 4.00e-02 | -0.375000 | 1.13e-01 |
| Constitutive Signaling by Overexpressed ERBB2 | 10 | 4.06e-02 | -0.374000 | 1.14e-01 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | 58 | 8.99e-07 | -0.373000 | 1.26e-05 |
| Processing of Capped Intronless Pre-mRNA | 28 | 6.46e-04 | -0.372000 | 3.88e-03 |
| RNA Polymerase III Transcription Termination | 23 | 2.10e-03 | -0.370000 | 1.11e-02 |
| Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 14 | 1.64e-02 | 0.370000 | 5.77e-02 |
| Diseases of hemostasis | 14 | 1.64e-02 | 0.370000 | 5.77e-02 |
| Nitric oxide stimulates guanylate cyclase | 22 | 2.68e-03 | 0.370000 | 1.33e-02 |
| Free fatty acids regulate insulin secretion | 10 | 4.49e-02 | 0.366000 | 1.24e-01 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 95 | 6.85e-10 | -0.366000 | 2.09e-08 |
| SUMOylation of transcription factors | 20 | 4.62e-03 | -0.366000 | 2.01e-02 |
| UCH proteinases | 81 | 1.24e-08 | -0.366000 | 2.92e-07 |
| Degradation of cysteine and homocysteine | 14 | 1.81e-02 | -0.365000 | 6.19e-02 |
| Cytosolic iron-sulfur cluster assembly | 10 | 4.74e-02 | -0.362000 | 1.27e-01 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | 27 | 1.14e-03 | -0.362000 | 6.39e-03 |
| Synthesis of glycosylphosphatidylinositol (GPI) | 17 | 9.84e-03 | -0.361000 | 3.88e-02 |
| RNA Polymerase I Promoter Escape | 28 | 9.41e-04 | -0.361000 | 5.32e-03 |
| Formation of TC-NER Pre-Incision Complex | 51 | 8.74e-06 | -0.360000 | 8.67e-05 |
| Creation of C4 and C2 activators | 14 | 1.99e-02 | 0.359000 | 6.70e-02 |
| NIK–>noncanonical NF-kB signaling | 57 | 2.67e-06 | -0.359000 | 3.16e-05 |
| Zinc transporters | 17 | 1.04e-02 | -0.359000 | 4.06e-02 |
| Respiratory electron transport | 90 | 3.92e-09 | -0.359000 | 1.01e-07 |
| SLBP independent Processing of Histone Pre-mRNAs | 10 | 4.95e-02 | -0.359000 | 1.32e-01 |
| NF-kB is activated and signals survival | 12 | 3.22e-02 | -0.357000 | 9.48e-02 |
| DNA Damage Recognition in GG-NER | 36 | 2.13e-04 | -0.357000 | 1.49e-03 |
| Cyclin E associated events during G1/S transition | 81 | 2.98e-08 | -0.356000 | 6.33e-07 |
| Expression and translocation of olfactory receptors | 365 | 1.18e-31 | 0.356000 | 3.67e-29 |
| Regulation of Apoptosis | 51 | 1.18e-05 | -0.354000 | 1.12e-04 |
| mRNA Capping | 28 | 1.17e-03 | -0.354000 | 6.53e-03 |
| Hedgehog ligand biogenesis | 63 | 1.20e-06 | -0.354000 | 1.61e-05 |
| Cleavage of the damaged pyrimidine | 16 | 1.44e-02 | -0.353000 | 5.23e-02 |
| Depyrimidination | 16 | 1.44e-02 | -0.353000 | 5.23e-02 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | 16 | 1.44e-02 | -0.353000 | 5.23e-02 |
| Cyclin A:Cdk2-associated events at S phase entry | 83 | 2.73e-08 | -0.353000 | 6.04e-07 |
| Olfactory Signaling Pathway | 372 | 1.20e-31 | 0.352000 | 3.67e-29 |
| Apoptotic factor-mediated response | 17 | 1.20e-02 | -0.352000 | 4.57e-02 |
| Regulation of APC/C activators between G1/S and early anaphase | 79 | 6.69e-08 | -0.351000 | 1.27e-06 |
| Stabilization of p53 | 55 | 6.60e-06 | -0.351000 | 6.88e-05 |
| HIV Transcription Initiation | 43 | 7.45e-05 | -0.349000 | 5.93e-04 |
| RNA Polymerase II HIV Promoter Escape | 43 | 7.45e-05 | -0.349000 | 5.93e-04 |
| RNA Polymerase II Promoter Escape | 43 | 7.45e-05 | -0.349000 | 5.93e-04 |
| RNA Polymerase II Transcription Initiation | 43 | 7.45e-05 | -0.349000 | 5.93e-04 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | 43 | 7.45e-05 | -0.349000 | 5.93e-04 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 43 | 7.45e-05 | -0.349000 | 5.93e-04 |
| FGFRL1 modulation of FGFR1 signaling | 13 | 2.95e-02 | -0.349000 | 8.86e-02 |
| Formation of HIV elongation complex in the absence of HIV Tat | 40 | 1.43e-04 | -0.347000 | 1.05e-03 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | 87 | 2.12e-08 | -0.347000 | 4.76e-07 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 72 | 3.72e-07 | -0.346000 | 5.58e-06 |
| Platelet Adhesion to exposed collagen | 13 | 3.07e-02 | 0.346000 | 9.09e-02 |
| Complement cascade | 56 | 7.42e-06 | 0.346000 | 7.61e-05 |
| Regulation of Complement cascade | 45 | 5.94e-05 | 0.346000 | 5.01e-04 |
| RNA Polymerase I Transcription Termination | 27 | 1.89e-03 | -0.345000 | 1.00e-02 |
| Sensory perception of taste | 47 | 4.59e-05 | 0.343000 | 3.92e-04 |
| GLI3 is processed to GLI3R by the proteasome | 58 | 6.17e-06 | -0.343000 | 6.60e-05 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 32 | 7.86e-04 | -0.343000 | 4.56e-03 |
| Collagen chain trimerization | 42 | 1.32e-04 | 0.341000 | 9.88e-04 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | 28 | 1.82e-03 | -0.340000 | 9.77e-03 |
| Bicarbonate transporters | 10 | 6.41e-02 | 0.338000 | 1.60e-01 |
| RNA Pol II CTD phosphorylation and interaction with CE | 26 | 2.86e-03 | -0.338000 | 1.40e-02 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 26 | 2.86e-03 | -0.338000 | 1.40e-02 |
| Transcription of the HIV genome | 62 | 4.23e-06 | -0.338000 | 4.72e-05 |
| Dectin-1 mediated noncanonical NF-kB signaling | 60 | 6.34e-06 | -0.337000 | 6.73e-05 |
| PINK1-PRKN Mediated Mitophagy | 21 | 7.53e-03 | -0.337000 | 3.11e-02 |
| Orc1 removal from chromatin | 69 | 1.35e-06 | -0.336000 | 1.72e-05 |
| APC/C-mediated degradation of cell cycle proteins | 86 | 6.94e-08 | -0.336000 | 1.27e-06 |
| Regulation of mitotic cell cycle | 86 | 6.94e-08 | -0.336000 | 1.27e-06 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | 38 | 3.52e-04 | -0.335000 | 2.34e-03 |
| HIV Transcription Elongation | 38 | 3.52e-04 | -0.335000 | 2.34e-03 |
| Tat-mediated elongation of the HIV-1 transcript | 38 | 3.52e-04 | -0.335000 | 2.34e-03 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | 11 | 5.54e-02 | -0.333000 | 1.44e-01 |
| Regulated proteolysis of p75NTR | 11 | 5.56e-02 | -0.333000 | 1.44e-01 |
| Defective CFTR causes cystic fibrosis | 59 | 9.64e-06 | -0.333000 | 9.50e-05 |
| RIP-mediated NFkB activation via ZBP1 | 16 | 2.15e-02 | -0.332000 | 7.04e-02 |
| p38MAPK events | 13 | 3.83e-02 | -0.332000 | 1.09e-01 |
| Cross-presentation of soluble exogenous antigens (endosomes) | 48 | 7.00e-05 | -0.332000 | 5.75e-04 |
| CASP8 activity is inhibited | 11 | 5.71e-02 | -0.331000 | 1.47e-01 |
| Dimerization of procaspase-8 | 11 | 5.71e-02 | -0.331000 | 1.47e-01 |
| Regulation by c-FLIP | 11 | 5.71e-02 | -0.331000 | 1.47e-01 |
| Initial triggering of complement | 21 | 8.68e-03 | 0.331000 | 3.48e-02 |
| Regulation of TP53 Activity through Phosphorylation | 88 | 9.63e-08 | -0.329000 | 1.62e-06 |
| Degradation of GLI2 by the proteasome | 58 | 1.51e-05 | -0.328000 | 1.41e-04 |
| Signaling by ROBO receptors | 203 | 6.72e-16 | -0.328000 | 2.93e-14 |
| Degradation of DVL | 55 | 2.64e-05 | -0.327000 | 2.39e-04 |
| VLDLR internalisation and degradation | 16 | 2.38e-02 | -0.326000 | 7.47e-02 |
| APC-Cdc20 mediated degradation of Nek2A | 26 | 3.98e-03 | -0.326000 | 1.80e-02 |
| RIPK1-mediated regulated necrosis | 27 | 3.43e-03 | -0.325000 | 1.59e-02 |
| Regulation of necroptotic cell death | 27 | 3.43e-03 | -0.325000 | 1.59e-02 |
| rRNA modification in the nucleus and cytosol | 55 | 3.05e-05 | -0.325000 | 2.69e-04 |
| Hormone ligand-binding receptors | 13 | 4.33e-02 | 0.324000 | 1.21e-01 |
| TP53 Regulates Transcription of Cell Cycle Genes | 49 | 8.96e-05 | -0.323000 | 6.91e-04 |
| Diseases associated with glycosylation precursor biosynthesis | 15 | 3.03e-02 | -0.323000 | 9.06e-02 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 17 | 2.14e-02 | -0.322000 | 7.04e-02 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 17 | 2.14e-02 | -0.322000 | 7.04e-02 |
| FOXO-mediated transcription of cell cycle genes | 16 | 2.57e-02 | -0.322000 | 7.93e-02 |
| Nuclear events mediated by NFE2L2 | 76 | 1.20e-06 | -0.322000 | 1.61e-05 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 10 | 7.81e-02 | -0.322000 | 1.85e-01 |
| TP53 Regulates Transcription of DNA Repair Genes | 57 | 2.64e-05 | -0.322000 | 2.39e-04 |
| Metallothioneins bind metals | 11 | 6.59e-02 | -0.320000 | 1.64e-01 |
| Signaling by NOTCH4 | 79 | 8.80e-07 | -0.320000 | 1.25e-05 |
| Mitochondrial iron-sulfur cluster biogenesis | 12 | 5.52e-02 | -0.320000 | 1.44e-01 |
| Switching of origins to a post-replicative state | 90 | 1.62e-07 | -0.319000 | 2.60e-06 |
| Josephin domain DUBs | 11 | 6.68e-02 | -0.319000 | 1.65e-01 |
| Fertilization | 26 | 4.85e-03 | 0.319000 | 2.09e-02 |
| mRNA Editing | 10 | 8.12e-02 | 0.318000 | 1.91e-01 |
| NRAGE signals death through JNK | 53 | 6.17e-05 | 0.318000 | 5.18e-04 |
| mRNA decay by 5’ to 3’ exoribonuclease | 15 | 3.32e-02 | -0.317000 | 9.70e-02 |
| Sensory Perception | 576 | 5.50e-39 | 0.317000 | 4.20e-36 |
| Degradation of GLI1 by the proteasome | 58 | 2.92e-05 | -0.317000 | 2.59e-04 |
| Apoptotic cleavage of cell adhesion proteins | 11 | 6.87e-02 | 0.317000 | 1.68e-01 |
| Signaling by FGFR2 IIIa TM | 19 | 1.71e-02 | -0.316000 | 5.95e-02 |
| Assembly of the pre-replicative complex | 82 | 7.62e-07 | -0.316000 | 1.10e-05 |
| Metabolism of RNA | 638 | 1.67e-42 | -0.316000 | 2.55e-39 |
| Glutamate and glutamine metabolism | 12 | 5.88e-02 | -0.315000 | 1.51e-01 |
| RAF-independent MAPK1/3 activation | 22 | 1.05e-02 | -0.315000 | 4.10e-02 |
| Glucocorticoid biosynthesis | 10 | 8.50e-02 | 0.314000 | 1.96e-01 |
| RNA Polymerase II Pre-transcription Events | 73 | 3.45e-06 | -0.314000 | 3.98e-05 |
| Adenylate cyclase activating pathway | 10 | 8.64e-02 | 0.313000 | 1.97e-01 |
| Activation of the TFAP2 (AP-2) family of transcription factors | 11 | 7.21e-02 | -0.313000 | 1.75e-01 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | 68 | 8.13e-06 | -0.313000 | 8.23e-05 |
| Mitochondrial protein import | 54 | 6.99e-05 | -0.313000 | 5.75e-04 |
| Defects in cobalamin (B12) metabolism | 12 | 6.16e-02 | -0.311000 | 1.55e-01 |
| Keratinization | 214 | 3.73e-15 | 0.311000 | 1.58e-13 |
| Presynaptic depolarization and calcium channel opening | 12 | 6.36e-02 | 0.309000 | 1.59e-01 |
| APC/C:Cdc20 mediated degradation of Cyclin B | 24 | 8.74e-03 | -0.309000 | 3.50e-02 |
| Formation of the Early Elongation Complex | 32 | 2.47e-03 | -0.309000 | 1.25e-02 |
| Formation of the HIV-1 Early Elongation Complex | 32 | 2.47e-03 | -0.309000 | 1.25e-02 |
| Scavenging by Class A Receptors | 19 | 1.97e-02 | 0.309000 | 6.67e-02 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | 15 | 3.83e-02 | 0.309000 | 1.09e-01 |
| Regulation of innate immune responses to cytosolic DNA | 14 | 4.57e-02 | -0.308000 | 1.25e-01 |
| The phototransduction cascade | 32 | 2.57e-03 | 0.308000 | 1.29e-02 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 32 | 2.58e-03 | -0.308000 | 1.29e-02 |
| Unwinding of DNA | 12 | 6.52e-02 | -0.307000 | 1.62e-01 |
| Thyroxine biosynthesis | 10 | 9.26e-02 | 0.307000 | 2.07e-01 |
| Cellular response to hypoxia | 71 | 8.20e-06 | -0.306000 | 8.24e-05 |
| Abacavir ADME | 10 | 9.43e-02 | 0.306000 | 2.10e-01 |
| Common Pathway of Fibrin Clot Formation | 21 | 1.54e-02 | 0.305000 | 5.50e-02 |
| mRNA Splicing | 183 | 1.08e-12 | -0.305000 | 3.92e-11 |
| ALK mutants bind TKIs | 12 | 6.83e-02 | 0.304000 | 1.68e-01 |
| Formation of apoptosome | 10 | 9.63e-02 | -0.304000 | 2.13e-01 |
| Regulation of the apoptosome activity | 10 | 9.63e-02 | -0.304000 | 2.13e-01 |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | 17 | 3.04e-02 | -0.303000 | 9.06e-02 |
| Cytochrome c-mediated apoptotic response | 12 | 6.90e-02 | -0.303000 | 1.69e-01 |
| Formation of the cornified envelope | 74 | 6.62e-06 | 0.303000 | 6.88e-05 |
| Senescence-Associated Secretory Phenotype (SASP) | 53 | 1.40e-04 | -0.302000 | 1.04e-03 |
| Negative epigenetic regulation of rRNA expression | 45 | 4.89e-04 | -0.300000 | 3.12e-03 |
| NoRC negatively regulates rRNA expression | 43 | 6.54e-04 | -0.300000 | 3.92e-03 |
| p130Cas linkage to MAPK signaling for integrins | 15 | 4.42e-02 | 0.300000 | 1.23e-01 |
| Collagen degradation | 39 | 1.23e-03 | 0.299000 | 6.81e-03 |
| Formation of RNA Pol II elongation complex | 53 | 1.72e-04 | -0.298000 | 1.24e-03 |
| RNA Polymerase II Transcription Elongation | 53 | 1.72e-04 | -0.298000 | 1.24e-03 |
| Activation of NF-kappaB in B cells | 64 | 3.68e-05 | -0.298000 | 3.21e-04 |
| Regulation of RAS by GAPs | 66 | 2.86e-05 | -0.298000 | 2.56e-04 |
| Signaling by Activin | 15 | 4.61e-02 | -0.297000 | 1.26e-01 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 62 | 5.42e-05 | -0.296000 | 4.60e-04 |
| Drug ADME | 98 | 3.98e-07 | 0.296000 | 5.91e-06 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | 21 | 1.92e-02 | -0.295000 | 6.51e-02 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | 21 | 1.92e-02 | -0.295000 | 6.51e-02 |
| Inactivation, recovery and regulation of the phototransduction cascade | 31 | 4.60e-03 | 0.294000 | 2.01e-02 |
| PKA activation in glucagon signalling | 17 | 3.58e-02 | 0.294000 | 1.04e-01 |
| Acetylcholine regulates insulin secretion | 10 | 1.08e-01 | 0.294000 | 2.31e-01 |
| mRNA Splicing - Major Pathway | 173 | 2.46e-11 | -0.294000 | 8.18e-10 |
| ZBP1(DAI) mediated induction of type I IFNs | 20 | 2.31e-02 | -0.293000 | 7.30e-02 |
| Purine ribonucleoside monophosphate biosynthesis | 11 | 9.46e-02 | -0.291000 | 2.10e-01 |
| Nephrin family interactions | 21 | 2.11e-02 | 0.291000 | 6.99e-02 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | 28 | 7.92e-03 | -0.290000 | 3.25e-02 |
| Trafficking of GluR2-containing AMPA receptors | 15 | 5.20e-02 | 0.290000 | 1.38e-01 |
| DNA Replication Pre-Initiation | 97 | 9.41e-07 | -0.288000 | 1.31e-05 |
| XBP1(S) activates chaperone genes | 48 | 5.57e-04 | -0.288000 | 3.45e-03 |
| The citric acid (TCA) cycle and respiratory electron transport | 143 | 2.73e-09 | -0.288000 | 7.60e-08 |
| Complex I biogenesis | 49 | 4.90e-04 | -0.288000 | 3.12e-03 |
| Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 14 | 6.32e-02 | 0.287000 | 1.59e-01 |
| TICAM1, RIP1-mediated IKK complex recruitment | 18 | 3.53e-02 | -0.287000 | 1.02e-01 |
| B-WICH complex positively regulates rRNA expression | 29 | 7.69e-03 | -0.286000 | 3.17e-02 |
| Glycogen breakdown (glycogenolysis) | 12 | 8.66e-02 | -0.286000 | 1.97e-01 |
| G1/S Transition | 126 | 3.28e-08 | -0.285000 | 6.76e-07 |
| Formation of Fibrin Clot (Clotting Cascade) | 37 | 2.71e-03 | 0.285000 | 1.34e-02 |
| Diseases associated with visual transduction | 11 | 1.03e-01 | 0.284000 | 2.24e-01 |
| Diseases of the neuronal system | 11 | 1.03e-01 | 0.284000 | 2.24e-01 |
| Retinoid cycle disease events | 11 | 1.03e-01 | 0.284000 | 2.24e-01 |
| G2/M Checkpoints | 129 | 2.77e-08 | -0.283000 | 6.05e-07 |
| Transport of organic anions | 10 | 1.22e-01 | 0.283000 | 2.53e-01 |
| The canonical retinoid cycle in rods (twilight vision) | 23 | 1.90e-02 | 0.282000 | 6.47e-02 |
| Regulation of RUNX2 expression and activity | 71 | 4.03e-05 | -0.282000 | 3.48e-04 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | 22 | 2.25e-02 | -0.281000 | 7.22e-02 |
| tRNA processing in the nucleus | 55 | 3.12e-04 | -0.281000 | 2.11e-03 |
| ER-Phagosome pathway | 87 | 5.98e-06 | -0.281000 | 6.44e-05 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | 21 | 2.66e-02 | -0.279000 | 8.10e-02 |
| Cleavage of the damaged purine | 11 | 1.10e-01 | -0.278000 | 2.35e-01 |
| Depurination | 11 | 1.10e-01 | -0.278000 | 2.35e-01 |
| Recognition and association of DNA glycosylase with site containing an affected purine | 11 | 1.10e-01 | -0.278000 | 2.35e-01 |
| Caspase activation via Death Receptors in the presence of ligand | 16 | 5.46e-02 | -0.277000 | 1.43e-01 |
| Neurotoxicity of clostridium toxins | 10 | 1.29e-01 | -0.277000 | 2.61e-01 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 18 | 4.19e-02 | -0.277000 | 1.18e-01 |
| Processing of Capped Intron-Containing Pre-mRNA | 231 | 4.92e-13 | -0.276000 | 1.83e-11 |
| Defective B3GALTL causes PpS | 36 | 4.37e-03 | 0.274000 | 1.92e-02 |
| G1/S-Specific Transcription | 28 | 1.20e-02 | -0.274000 | 4.57e-02 |
| PCP/CE pathway | 90 | 7.04e-06 | -0.274000 | 7.27e-05 |
| DNA Damage/Telomere Stress Induced Senescence | 28 | 1.22e-02 | -0.274000 | 4.62e-02 |
| MAPK6/MAPK4 signaling | 89 | 8.41e-06 | -0.273000 | 8.40e-05 |
| Transcriptional regulation of granulopoiesis | 31 | 8.66e-03 | -0.272000 | 3.48e-02 |
| Other semaphorin interactions | 18 | 4.58e-02 | 0.272000 | 1.25e-01 |
| O-glycosylation of TSR domain-containing proteins | 37 | 4.29e-03 | 0.271000 | 1.90e-02 |
| Synthesis of DNA | 118 | 3.59e-07 | -0.271000 | 5.42e-06 |
| Methylation | 14 | 7.94e-02 | -0.271000 | 1.87e-01 |
| Processing of DNA double-strand break ends | 61 | 2.58e-04 | -0.270000 | 1.78e-03 |
| IRE1alpha activates chaperones | 50 | 9.57e-04 | -0.270000 | 5.39e-03 |
| Cyclin A/B1/B2 associated events during G2/M transition | 24 | 2.22e-02 | -0.270000 | 7.17e-02 |
| Degradation of beta-catenin by the destruction complex | 81 | 2.75e-05 | -0.269000 | 2.47e-04 |
| Organic cation/anion/zwitterion transport | 15 | 7.13e-02 | 0.269000 | 1.73e-01 |
| FGFR2 mutant receptor activation | 32 | 8.62e-03 | -0.268000 | 3.48e-02 |
| Activation of the AP-1 family of transcription factors | 10 | 1.42e-01 | -0.268000 | 2.80e-01 |
| DNA Replication | 125 | 2.41e-07 | -0.267000 | 3.76e-06 |
| Keratan sulfate degradation | 12 | 1.11e-01 | 0.266000 | 2.37e-01 |
| PERK regulates gene expression | 32 | 9.45e-03 | -0.265000 | 3.75e-02 |
| Organic cation transport | 10 | 1.47e-01 | 0.265000 | 2.87e-01 |
| GABA synthesis, release, reuptake and degradation | 19 | 4.56e-02 | -0.265000 | 1.25e-01 |
| Sulfur amino acid metabolism | 27 | 1.72e-02 | -0.265000 | 5.95e-02 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 13 | 9.87e-02 | 0.264000 | 2.17e-01 |
| Visual phototransduction | 93 | 1.04e-05 | 0.264000 | 1.01e-04 |
| Mitophagy | 27 | 1.79e-02 | -0.263000 | 6.14e-02 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 12 | 1.14e-01 | 0.263000 | 2.42e-01 |
| Defective EXT2 causes exostoses 2 | 12 | 1.14e-01 | 0.263000 | 2.42e-01 |
| Initiation of Nuclear Envelope (NE) Reformation | 18 | 5.32e-02 | -0.263000 | 1.41e-01 |
| Mitotic G1 phase and G1/S transition | 144 | 5.78e-08 | -0.262000 | 1.15e-06 |
| Cytosolic sensors of pathogen-associated DNA | 60 | 4.60e-04 | -0.261000 | 2.97e-03 |
| Unfolded Protein Response (UPR) | 91 | 1.70e-05 | -0.261000 | 1.58e-04 |
| RNA polymerase II transcribes snRNA genes | 77 | 7.67e-05 | -0.261000 | 6.07e-04 |
| WNT ligand biogenesis and trafficking | 25 | 2.48e-02 | -0.259000 | 7.67e-02 |
| RNA Polymerase III Transcription Initiation | 36 | 7.07e-03 | -0.259000 | 2.94e-02 |
| FCERI mediated NF-kB activation | 74 | 1.17e-04 | -0.259000 | 8.88e-04 |
| ERK/MAPK targets | 20 | 4.56e-02 | -0.258000 | 1.25e-01 |
| Signalling to RAS | 20 | 4.57e-02 | -0.258000 | 1.25e-01 |
| tRNA processing | 98 | 1.03e-05 | -0.258000 | 1.01e-04 |
| Killing mechanisms | 11 | 1.40e-01 | -0.257000 | 2.77e-01 |
| WNT5:FZD7-mediated leishmania damping | 11 | 1.40e-01 | -0.257000 | 2.77e-01 |
| TP53 Regulates Transcription of Death Receptors and Ligands | 12 | 1.23e-01 | -0.257000 | 2.55e-01 |
| Activation of Matrix Metalloproteinases | 31 | 1.33e-02 | 0.257000 | 4.97e-02 |
| Diseases of mitotic cell cycle | 37 | 7.01e-03 | -0.256000 | 2.92e-02 |
| Golgi Cisternae Pericentriolar Stack Reorganization | 14 | 9.98e-02 | -0.254000 | 2.19e-01 |
| Metabolism of non-coding RNA | 50 | 1.88e-03 | -0.254000 | 1.00e-02 |
| snRNP Assembly | 50 | 1.88e-03 | -0.254000 | 1.00e-02 |
| Transcriptional regulation by small RNAs | 46 | 2.91e-03 | -0.254000 | 1.41e-02 |
| HIV Life Cycle | 139 | 2.40e-07 | -0.254000 | 3.76e-06 |
| Regulation of PTEN stability and activity | 66 | 3.77e-04 | -0.253000 | 2.49e-03 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 76 | 1.37e-04 | -0.253000 | 1.01e-03 |
| Metabolism of Angiotensinogen to Angiotensins | 15 | 9.02e-02 | 0.253000 | 2.03e-01 |
| Telomere Maintenance | 62 | 6.03e-04 | -0.252000 | 3.66e-03 |
| Downregulation of TGF-beta receptor signaling | 26 | 2.65e-02 | -0.251000 | 8.10e-02 |
| Role of LAT2/NTAL/LAB on calcium mobilization | 13 | 1.17e-01 | 0.251000 | 2.46e-01 |
| Dectin-2 family | 28 | 2.15e-02 | 0.251000 | 7.04e-02 |
| Defective pyroptosis | 11 | 1.51e-01 | -0.250000 | 2.90e-01 |
| Nucleotide Excision Repair | 107 | 7.80e-06 | -0.250000 | 7.95e-05 |
| Netrin-1 signaling | 49 | 2.46e-03 | 0.250000 | 1.25e-02 |
| Crosslinking of collagen fibrils | 10 | 1.72e-01 | -0.250000 | 3.19e-01 |
| G0 and Early G1 | 27 | 2.50e-02 | -0.249000 | 7.72e-02 |
| Collagen biosynthesis and modifying enzymes | 65 | 5.19e-04 | 0.249000 | 3.27e-03 |
| mRNA decay by 3’ to 5’ exoribonuclease | 16 | 8.61e-02 | -0.248000 | 1.97e-01 |
| TNFR2 non-canonical NF-kB pathway | 94 | 3.26e-05 | -0.248000 | 2.86e-04 |
| RNA Polymerase II Transcription Termination | 62 | 7.61e-04 | -0.247000 | 4.46e-03 |
| Chemokine receptors bind chemokines | 56 | 1.46e-03 | 0.246000 | 8.00e-03 |
| Aspartate and asparagine metabolism | 12 | 1.41e-01 | 0.246000 | 2.78e-01 |
| MET promotes cell motility | 29 | 2.22e-02 | 0.245000 | 7.17e-02 |
| Myogenesis | 29 | 2.23e-02 | 0.245000 | 7.17e-02 |
| Synthesis of IP2, IP, and Ins in the cytosol | 13 | 1.26e-01 | 0.245000 | 2.59e-01 |
| Association of TriC/CCT with target proteins during biosynthesis | 38 | 9.00e-03 | -0.245000 | 3.59e-02 |
| Spry regulation of FGF signaling | 16 | 9.14e-02 | -0.244000 | 2.05e-01 |
| Downstream signaling events of B Cell Receptor (BCR) | 78 | 1.97e-04 | -0.244000 | 1.39e-03 |
| Processing and activation of SUMO | 10 | 1.82e-01 | -0.244000 | 3.34e-01 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | 36 | 1.16e-02 | -0.243000 | 4.45e-02 |
| Viral Messenger RNA Synthesis | 42 | 6.41e-03 | -0.243000 | 2.70e-02 |
| S Phase | 157 | 1.45e-07 | -0.243000 | 2.35e-06 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 19 | 6.68e-02 | -0.243000 | 1.65e-01 |
| LGI-ADAM interactions | 14 | 1.16e-01 | -0.243000 | 2.44e-01 |
| Negative regulation of TCF-dependent signaling by WNT ligand antagonists | 15 | 1.03e-01 | -0.243000 | 2.25e-01 |
| TRP channels | 24 | 4.04e-02 | 0.242000 | 1.14e-01 |
| ATF4 activates genes in response to endoplasmic reticulum stress | 28 | 2.71e-02 | -0.241000 | 8.23e-02 |
| Paracetamol ADME | 30 | 2.23e-02 | 0.241000 | 7.17e-02 |
| HIV Infection | 216 | 1.12e-09 | -0.240000 | 3.35e-08 |
| Formation of tubulin folding intermediates by CCT/TriC | 26 | 3.40e-02 | -0.240000 | 9.88e-02 |
| Signaling by NTRK1 (TRKA) | 114 | 1.07e-05 | -0.238000 | 1.04e-04 |
| Calnexin/calreticulin cycle | 25 | 3.90e-02 | -0.238000 | 1.11e-01 |
| Lysine catabolism | 12 | 1.53e-01 | 0.238000 | 2.92e-01 |
| MAPK targets/ Nuclear events mediated by MAP kinases | 29 | 2.66e-02 | -0.238000 | 8.10e-02 |
| Late Phase of HIV Life Cycle | 126 | 4.02e-06 | -0.238000 | 4.52e-05 |
| RNA Polymerase III Abortive And Retractive Initiation | 41 | 8.55e-03 | -0.237000 | 3.48e-02 |
| RNA Polymerase III Transcription | 41 | 8.55e-03 | -0.237000 | 3.48e-02 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 36 | 1.38e-02 | -0.237000 | 5.10e-02 |
| STAT5 activation downstream of FLT3 ITD mutants | 10 | 1.95e-01 | -0.237000 | 3.49e-01 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 34 | 1.69e-02 | -0.237000 | 5.92e-02 |
| Regulation of pyruvate dehydrogenase (PDH) complex | 14 | 1.26e-01 | -0.236000 | 2.59e-01 |
| Host Interactions of HIV factors | 122 | 6.53e-06 | -0.236000 | 6.88e-05 |
| RAC1 GTPase cycle | 170 | 1.10e-07 | 0.236000 | 1.81e-06 |
| Transcriptional regulation by RUNX3 | 93 | 8.64e-05 | -0.235000 | 6.70e-04 |
| Diseases of DNA repair | 49 | 4.43e-03 | -0.235000 | 1.94e-02 |
| Effects of PIP2 hydrolysis | 26 | 3.84e-02 | 0.235000 | 1.09e-01 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | 15 | 1.16e-01 | -0.234000 | 2.45e-01 |
| Protein methylation | 16 | 1.05e-01 | -0.234000 | 2.27e-01 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | 62 | 1.42e-03 | -0.234000 | 7.82e-03 |
| Interconversion of nucleotide di- and triphosphates | 29 | 2.94e-02 | -0.234000 | 8.84e-02 |
| Sema3A PAK dependent Axon repulsion | 14 | 1.31e-01 | 0.233000 | 2.65e-01 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | 13 | 1.47e-01 | -0.232000 | 2.87e-01 |
| Signaling by Hippo | 19 | 7.96e-02 | 0.232000 | 1.87e-01 |
| ABC transporters in lipid homeostasis | 17 | 9.81e-02 | 0.232000 | 2.16e-01 |
| IKK complex recruitment mediated by RIP1 | 22 | 6.01e-02 | -0.231000 | 1.53e-01 |
| Transcriptional Regulation by TP53 | 346 | 1.28e-13 | -0.231000 | 5.17e-12 |
| Signaling by high-kinase activity BRAF mutants | 32 | 2.40e-02 | 0.230000 | 7.47e-02 |
| Neurexins and neuroligins | 52 | 4.11e-03 | 0.230000 | 1.85e-02 |
| G2/M DNA damage checkpoint | 58 | 2.48e-03 | -0.230000 | 1.25e-02 |
| Regulation of PTEN gene transcription | 59 | 2.32e-03 | -0.229000 | 1.20e-02 |
| Antigen processing-Cross presentation | 102 | 6.36e-05 | -0.229000 | 5.31e-04 |
| Stimuli-sensing channels | 96 | 1.06e-04 | 0.229000 | 8.09e-04 |
| mRNA 3’-end processing | 53 | 4.14e-03 | -0.228000 | 1.86e-02 |
| BBSome-mediated cargo-targeting to cilium | 23 | 5.92e-02 | -0.227000 | 1.51e-01 |
| KEAP1-NFE2L2 pathway | 103 | 6.82e-05 | -0.227000 | 5.66e-04 |
| Phase 2 - plateau phase | 14 | 1.43e-01 | 0.226000 | 2.81e-01 |
| Binding and Uptake of Ligands by Scavenger Receptors | 41 | 1.22e-02 | 0.226000 | 4.64e-02 |
| MicroRNA (miRNA) biogenesis | 26 | 4.61e-02 | -0.226000 | 1.26e-01 |
| ECM proteoglycans | 55 | 3.76e-03 | 0.226000 | 1.72e-02 |
| Postmitotic nuclear pore complex (NPC) reformation | 26 | 4.64e-02 | -0.226000 | 1.26e-01 |
| Response to metal ions | 14 | 1.44e-01 | -0.226000 | 2.82e-01 |
| Non-integrin membrane-ECM interactions | 40 | 1.36e-02 | 0.225000 | 5.07e-02 |
| Assembly Of The HIV Virion | 16 | 1.19e-01 | -0.225000 | 2.48e-01 |
| Impaired BRCA2 binding to RAD51 | 33 | 2.52e-02 | -0.225000 | 7.78e-02 |
| Diseases of programmed cell death | 41 | 1.29e-02 | -0.224000 | 4.84e-02 |
| CDC42 GTPase cycle | 144 | 3.47e-06 | 0.224000 | 3.98e-05 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 14 | 1.49e-01 | -0.223000 | 2.89e-01 |
| Cell-cell junction organization | 56 | 3.93e-03 | 0.223000 | 1.78e-02 |
| ER Quality Control Compartment (ERQC) | 20 | 8.48e-02 | -0.223000 | 1.95e-01 |
| Signaling by FGFR2 in disease | 42 | 1.26e-02 | -0.222000 | 4.75e-02 |
| Dual incision in TC-NER | 63 | 2.27e-03 | -0.222000 | 1.17e-02 |
| Antimicrobial peptides | 82 | 5.02e-04 | 0.222000 | 3.18e-03 |
| Phospholipase C-mediated cascade: FGFR1 | 16 | 1.25e-01 | -0.221000 | 2.58e-01 |
| Ub-specific processing proteases | 157 | 1.75e-06 | -0.221000 | 2.21e-05 |
| Regulation of IFNG signaling | 14 | 1.52e-01 | -0.221000 | 2.92e-01 |
| Separation of Sister Chromatids | 161 | 1.34e-06 | -0.221000 | 1.72e-05 |
| VEGFR2 mediated vascular permeability | 26 | 5.19e-02 | 0.220000 | 1.38e-01 |
| Hedgehog ‘on’ state | 83 | 5.25e-04 | -0.220000 | 3.28e-03 |
| O-linked glycosylation | 107 | 8.43e-05 | 0.220000 | 6.60e-04 |
| Defensins | 40 | 1.64e-02 | 0.219000 | 5.77e-02 |
| Cell Cycle Checkpoints | 248 | 2.88e-09 | -0.219000 | 7.72e-08 |
| PLC beta mediated events | 47 | 9.57e-03 | 0.218000 | 3.79e-02 |
| Signaling by RAF1 mutants | 37 | 2.15e-02 | 0.218000 | 7.04e-02 |
| Global Genome Nucleotide Excision Repair (GG-NER) | 81 | 6.85e-04 | -0.218000 | 4.06e-03 |
| Phenylalanine and tyrosine metabolism | 10 | 2.33e-01 | 0.218000 | 3.93e-01 |
| Nucleotide biosynthesis | 14 | 1.58e-01 | -0.218000 | 3.00e-01 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 13 | 1.74e-01 | -0.218000 | 3.23e-01 |
| TP53 Regulates Transcription of Cell Death Genes | 42 | 1.48e-02 | -0.217000 | 5.34e-02 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 20 | 9.30e-02 | -0.217000 | 2.08e-01 |
| Activation of HOX genes during differentiation | 61 | 3.41e-03 | -0.217000 | 1.59e-02 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | 61 | 3.41e-03 | -0.217000 | 1.59e-02 |
| CRMPs in Sema3A signaling | 15 | 1.46e-01 | 0.217000 | 2.87e-01 |
| Beta defensins | 32 | 3.40e-02 | 0.217000 | 9.88e-02 |
| PRC2 methylates histones and DNA | 13 | 1.78e-01 | -0.216000 | 3.28e-01 |
| Acyl chain remodelling of PS | 21 | 8.73e-02 | 0.215000 | 1.98e-01 |
| Diseases associated with O-glycosylation of proteins | 66 | 2.49e-03 | 0.215000 | 1.25e-02 |
| Signaling by FGFR2 | 72 | 1.59e-03 | -0.215000 | 8.67e-03 |
| RHOU GTPase cycle | 37 | 2.39e-02 | 0.214000 | 7.47e-02 |
| Chromosome Maintenance | 86 | 5.83e-04 | -0.214000 | 3.59e-03 |
| Laminin interactions | 23 | 7.55e-02 | 0.214000 | 1.80e-01 |
| Diseases associated with N-glycosylation of proteins | 19 | 1.07e-01 | -0.214000 | 2.30e-01 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 12 | 2.00e-01 | -0.213000 | 3.55e-01 |
| Biotin transport and metabolism | 10 | 2.43e-01 | 0.213000 | 4.03e-01 |
| Downstream TCR signaling | 92 | 4.20e-04 | -0.213000 | 2.74e-03 |
| Degradation of the extracellular matrix | 108 | 1.44e-04 | 0.212000 | 1.05e-03 |
| Cellular responses to stimuli | 697 | 1.47e-21 | -0.211000 | 1.07e-19 |
| Cellular responses to stress | 683 | 4.54e-21 | -0.211000 | 3.02e-19 |
| Interleukin-7 signaling | 21 | 9.59e-02 | -0.210000 | 2.13e-01 |
| Mitotic Metaphase and Anaphase | 222 | 7.29e-08 | -0.209000 | 1.30e-06 |
| RAB geranylgeranylation | 57 | 6.29e-03 | -0.209000 | 2.66e-02 |
| Synthesis of PA | 35 | 3.25e-02 | 0.209000 | 9.52e-02 |
| Mitotic Anaphase | 221 | 9.32e-08 | -0.208000 | 1.60e-06 |
| Dissolution of Fibrin Clot | 13 | 1.94e-01 | 0.208000 | 3.48e-01 |
| Interleukin-1 signaling | 97 | 4.04e-04 | -0.208000 | 2.65e-03 |
| Endogenous sterols | 26 | 6.72e-02 | 0.207000 | 1.65e-01 |
| Insulin receptor recycling | 25 | 7.29e-02 | -0.207000 | 1.75e-01 |
| Regulation of gene expression by Hypoxia-inducible Factor | 11 | 2.34e-01 | -0.207000 | 3.96e-01 |
| Interleukin-2 signaling | 11 | 2.37e-01 | -0.206000 | 3.97e-01 |
| Cyclin D associated events in G1 | 46 | 1.57e-02 | -0.206000 | 5.55e-02 |
| G1 Phase | 46 | 1.57e-02 | -0.206000 | 5.55e-02 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 39 | 2.61e-02 | -0.206000 | 8.02e-02 |
| Diseases of DNA Double-Strand Break Repair | 39 | 2.61e-02 | -0.206000 | 8.02e-02 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 16 | 1.55e-01 | -0.205000 | 2.95e-01 |
| Extracellular matrix organization | 288 | 1.97e-09 | 0.205000 | 5.79e-08 |
| Purine salvage | 12 | 2.19e-01 | -0.205000 | 3.76e-01 |
| TRAF6 mediated NF-kB activation | 24 | 8.20e-02 | -0.205000 | 1.91e-01 |
| Assembly of the ORC complex at the origin of replication | 10 | 2.64e-01 | 0.204000 | 4.25e-01 |
| Ketone body metabolism | 10 | 2.65e-01 | 0.204000 | 4.25e-01 |
| Deactivation of the beta-catenin transactivating complex | 39 | 2.79e-02 | -0.203000 | 8.45e-02 |
| Defective Intrinsic Pathway for Apoptosis | 25 | 7.87e-02 | -0.203000 | 1.86e-01 |
| tRNA modification in the nucleus and cytosol | 38 | 3.03e-02 | -0.203000 | 9.06e-02 |
| L1CAM interactions | 92 | 7.80e-04 | 0.203000 | 4.55e-03 |
| G alpha (12/13) signalling events | 74 | 2.59e-03 | 0.202000 | 1.29e-02 |
| Regulation of TNFR1 signaling | 32 | 4.77e-02 | -0.202000 | 1.28e-01 |
| Signaling by FLT3 ITD and TKD mutants | 16 | 1.62e-01 | -0.202000 | 3.05e-01 |
| Mitotic G2-G2/M phases | 178 | 3.50e-06 | -0.201000 | 3.99e-05 |
| Cytoprotection by HMOX1 | 58 | 7.97e-03 | -0.201000 | 3.26e-02 |
| RHOQ GTPase cycle | 57 | 8.62e-03 | 0.201000 | 3.48e-02 |
| Phosphorylation of the APC/C | 20 | 1.20e-01 | -0.201000 | 2.49e-01 |
| RNA Polymerase I Transcription | 47 | 1.72e-02 | -0.201000 | 5.95e-02 |
| TNFR1-induced proapoptotic signaling | 13 | 2.10e-01 | -0.201000 | 3.68e-01 |
| Metabolism of steroid hormones | 33 | 4.59e-02 | 0.201000 | 1.25e-01 |
| Regulation of TP53 Activity | 154 | 1.71e-05 | -0.201000 | 1.58e-04 |
| G2/M Transition | 176 | 4.37e-06 | -0.200000 | 4.84e-05 |
| HDR through Single Strand Annealing (SSA) | 36 | 3.75e-02 | -0.200000 | 1.08e-01 |
| Metal ion SLC transporters | 25 | 8.30e-02 | -0.200000 | 1.93e-01 |
| Positive epigenetic regulation of rRNA expression | 43 | 2.31e-02 | -0.200000 | 7.30e-02 |
| Sodium/Calcium exchangers | 11 | 2.51e-01 | 0.200000 | 4.12e-01 |
| Trafficking and processing of endosomal TLR | 11 | 2.55e-01 | -0.198000 | 4.15e-01 |
| Regulation of localization of FOXO transcription factors | 11 | 2.55e-01 | 0.198000 | 4.15e-01 |
| Transcriptional regulation by RUNX2 | 116 | 2.23e-04 | -0.198000 | 1.56e-03 |
| Homologous DNA Pairing and Strand Exchange | 41 | 2.83e-02 | -0.198000 | 8.56e-02 |
| Negative regulation of FLT3 | 15 | 1.85e-01 | -0.197000 | 3.38e-01 |
| Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 10 | 2.80e-01 | -0.197000 | 4.41e-01 |
| O-linked glycosylation of mucins | 62 | 7.31e-03 | 0.197000 | 3.03e-02 |
| FGFR1 ligand binding and activation | 15 | 1.88e-01 | -0.196000 | 3.40e-01 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 19 | 1.39e-01 | -0.196000 | 2.77e-01 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | 19 | 1.39e-01 | -0.196000 | 2.77e-01 |
| Collagen formation | 88 | 1.53e-03 | 0.195000 | 8.35e-03 |
| Epigenetic regulation of gene expression | 83 | 2.10e-03 | -0.195000 | 1.11e-02 |
| Synthesis of PIPs at the plasma membrane | 48 | 2.00e-02 | 0.194000 | 6.73e-02 |
| MyD88 dependent cascade initiated on endosome | 84 | 2.15e-03 | -0.194000 | 1.12e-02 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | 84 | 2.15e-03 | -0.194000 | 1.12e-02 |
| DNA Repair | 277 | 2.84e-08 | -0.193000 | 6.12e-07 |
| SHC-mediated cascade:FGFR1 | 21 | 1.25e-01 | -0.193000 | 2.57e-01 |
| Presynaptic phase of homologous DNA pairing and strand exchange | 38 | 3.91e-02 | -0.193000 | 1.11e-01 |
| Homology Directed Repair | 100 | 8.38e-04 | -0.193000 | 4.83e-03 |
| Negative regulators of DDX58/IFIH1 signaling | 34 | 5.15e-02 | -0.193000 | 1.37e-01 |
| TP53 Regulates Metabolic Genes | 83 | 2.39e-03 | -0.193000 | 1.23e-02 |
| Activation of ATR in response to replication stress | 37 | 4.29e-02 | -0.192000 | 1.20e-01 |
| Cellular response to chemical stress | 187 | 5.73e-06 | -0.192000 | 6.26e-05 |
| Signaling by NTRKs | 133 | 1.32e-04 | -0.192000 | 9.88e-04 |
| RNA Polymerase I Promoter Clearance | 46 | 2.44e-02 | -0.192000 | 7.58e-02 |
| Signaling by BRAF and RAF1 fusions | 60 | 1.02e-02 | 0.192000 | 3.98e-02 |
| MyD88 cascade initiated on plasma membrane | 79 | 3.24e-03 | -0.191000 | 1.54e-02 |
| Toll Like Receptor 10 (TLR10) Cascade | 79 | 3.24e-03 | -0.191000 | 1.54e-02 |
| Toll Like Receptor 5 (TLR5) Cascade | 79 | 3.24e-03 | -0.191000 | 1.54e-02 |
| Negative regulation of MAPK pathway | 41 | 3.39e-02 | -0.191000 | 9.88e-02 |
| Notch-HLH transcription pathway | 24 | 1.05e-01 | 0.191000 | 2.27e-01 |
| Intrinsic Pathway for Apoptosis | 52 | 1.71e-02 | -0.191000 | 5.95e-02 |
| Tryptophan catabolism | 12 | 2.52e-01 | 0.191000 | 4.12e-01 |
| Negative regulation of FGFR1 signaling | 32 | 6.16e-02 | -0.191000 | 1.55e-01 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 29 | 7.52e-02 | 0.191000 | 1.80e-01 |
| CLEC7A (Dectin-1) signaling | 96 | 1.23e-03 | -0.191000 | 6.81e-03 |
| RHO GTPases activate IQGAPs | 11 | 2.74e-01 | 0.191000 | 4.33e-01 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 94 | 1.42e-03 | -0.190000 | 7.82e-03 |
| Selective autophagy | 59 | 1.18e-02 | -0.189000 | 4.53e-02 |
| RUNX2 regulates osteoblast differentiation | 22 | 1.24e-01 | -0.189000 | 2.56e-01 |
| Membrane binding and targetting of GAG proteins | 14 | 2.21e-01 | -0.189000 | 3.77e-01 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | 14 | 2.21e-01 | -0.189000 | 3.77e-01 |
| Base Excision Repair | 45 | 2.87e-02 | -0.188000 | 8.65e-02 |
| Ion transport by P-type ATPases | 51 | 2.01e-02 | 0.188000 | 6.73e-02 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 14 | 2.23e-01 | -0.188000 | 3.80e-01 |
| Metabolism of porphyrins | 27 | 9.13e-02 | 0.188000 | 2.05e-01 |
| Iron uptake and transport | 57 | 1.42e-02 | -0.188000 | 5.20e-02 |
| TRAF3-dependent IRF activation pathway | 15 | 2.09e-01 | -0.187000 | 3.67e-01 |
| Polo-like kinase mediated events | 16 | 1.95e-01 | -0.187000 | 3.48e-01 |
| Export of Viral Ribonucleoproteins from Nucleus | 31 | 7.12e-02 | -0.187000 | 1.73e-01 |
| Metabolism of amino acids and derivatives | 345 | 2.32e-09 | -0.187000 | 6.70e-08 |
| Signaling by FGFR | 85 | 2.97e-03 | -0.186000 | 1.43e-02 |
| Translesion Synthesis by POLH | 19 | 1.60e-01 | -0.186000 | 3.02e-01 |
| Oncogene Induced Senescence | 35 | 5.64e-02 | -0.186000 | 1.46e-01 |
| Other interleukin signaling | 24 | 1.14e-01 | -0.186000 | 2.42e-01 |
| Nuclear Envelope (NE) Reassembly | 73 | 6.03e-03 | -0.186000 | 2.56e-02 |
| DAG and IP3 signaling | 39 | 4.47e-02 | 0.186000 | 1.24e-01 |
| Retinoid metabolism and transport | 42 | 3.75e-02 | 0.185000 | 1.08e-01 |
| SUMOylation of SUMOylation proteins | 33 | 6.53e-02 | -0.185000 | 1.62e-01 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 83 | 3.55e-03 | -0.185000 | 1.62e-02 |
| Protein-protein interactions at synapses | 78 | 4.71e-03 | 0.185000 | 2.05e-02 |
| Signaling by NOTCH2 | 32 | 7.02e-02 | -0.185000 | 1.71e-01 |
| Signaling by ALK | 26 | 1.04e-01 | -0.184000 | 2.25e-01 |
| TCF dependent signaling in response to WNT | 168 | 3.75e-05 | -0.184000 | 3.26e-04 |
| Translesion synthesis by POLI | 17 | 1.90e-01 | -0.184000 | 3.43e-01 |
| FCGR3A-mediated IL10 synthesis | 37 | 5.34e-02 | 0.183000 | 1.41e-01 |
| Scavenging of heme from plasma | 12 | 2.72e-01 | 0.183000 | 4.32e-01 |
| Toll Like Receptor 3 (TLR3) Cascade | 88 | 3.01e-03 | -0.183000 | 1.45e-02 |
| Erythropoietin activates RAS | 14 | 2.36e-01 | -0.183000 | 3.97e-01 |
| Deadenylation-dependent mRNA decay | 56 | 1.80e-02 | -0.183000 | 6.16e-02 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 16 | 2.06e-01 | -0.183000 | 3.64e-01 |
| SARS-CoV-2-host interactions | 185 | 1.84e-05 | -0.182000 | 1.70e-04 |
| G-protein mediated events | 52 | 2.34e-02 | 0.182000 | 7.36e-02 |
| Interferon alpha/beta signaling | 71 | 8.09e-03 | -0.182000 | 3.31e-02 |
| Formation of Incision Complex in GG-NER | 40 | 4.67e-02 | -0.182000 | 1.26e-01 |
| Class B/2 (Secretin family receptors) | 94 | 2.34e-03 | -0.182000 | 1.20e-02 |
| Chaperonin-mediated protein folding | 90 | 2.98e-03 | -0.181000 | 1.44e-02 |
| AKT phosphorylates targets in the cytosol | 14 | 2.42e-01 | -0.181000 | 4.01e-01 |
| Mucopolysaccharidoses | 10 | 3.23e-01 | 0.181000 | 4.84e-01 |
| Generic Transcription Pathway | 1150 | 2.98e-25 | -0.181000 | 4.14e-23 |
| Activation of SMO | 17 | 1.98e-01 | -0.180000 | 3.51e-01 |
| Cell-Cell communication | 112 | 9.70e-04 | 0.180000 | 5.45e-03 |
| Resolution of Abasic Sites (AP sites) | 37 | 5.84e-02 | -0.180000 | 1.50e-01 |
| Deubiquitination | 230 | 2.95e-06 | -0.179000 | 3.47e-05 |
| RNA Polymerase II Transcription | 1271 | 4.86e-27 | -0.179000 | 1.06e-24 |
| CLEC7A (Dectin-1) induces NFAT activation | 11 | 3.05e-01 | 0.178000 | 4.68e-01 |
| Cell junction organization | 79 | 6.13e-03 | 0.178000 | 2.60e-02 |
| eNOS activation | 11 | 3.06e-01 | -0.178000 | 4.68e-01 |
| Synthesis of very long-chain fatty acyl-CoAs | 23 | 1.40e-01 | 0.178000 | 2.77e-01 |
| Interleukin-12 family signaling | 54 | 2.40e-02 | -0.178000 | 7.47e-02 |
| Downregulation of ERBB2:ERBB3 signaling | 13 | 2.68e-01 | -0.177000 | 4.29e-01 |
| Rev-mediated nuclear export of HIV RNA | 33 | 7.80e-02 | -0.177000 | 1.85e-01 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 38 | 5.87e-02 | -0.177000 | 1.51e-01 |
| Interleukin-12 signaling | 44 | 4.20e-02 | -0.177000 | 1.18e-01 |
| RMTs methylate histone arginines | 29 | 9.91e-02 | -0.177000 | 2.18e-01 |
| Alpha-protein kinase 1 signaling pathway | 10 | 3.33e-01 | -0.177000 | 4.98e-01 |
| Glutathione synthesis and recycling | 13 | 2.70e-01 | -0.177000 | 4.30e-01 |
| TNF signaling | 40 | 5.31e-02 | -0.177000 | 1.41e-01 |
| Toll Like Receptor 9 (TLR9) Cascade | 88 | 4.24e-03 | -0.176000 | 1.89e-02 |
| MyD88-independent TLR4 cascade | 92 | 3.49e-03 | -0.176000 | 1.60e-02 |
| TRIF(TICAM1)-mediated TLR4 signaling | 92 | 3.49e-03 | -0.176000 | 1.60e-02 |
| Post-translational protein phosphorylation | 100 | 2.43e-03 | 0.175000 | 1.24e-02 |
| Integrin cell surface interactions | 66 | 1.41e-02 | 0.175000 | 5.18e-02 |
| Transport of the SLBP Dependant Mature mRNA | 34 | 7.81e-02 | -0.175000 | 1.85e-01 |
| Glycogen metabolism | 24 | 1.39e-01 | -0.175000 | 2.77e-01 |
| Class I peroxisomal membrane protein import | 19 | 1.88e-01 | -0.174000 | 3.41e-01 |
| Neddylation | 228 | 5.86e-06 | -0.174000 | 6.35e-05 |
| Telomere Extension By Telomerase | 22 | 1.58e-01 | -0.174000 | 3.00e-01 |
| PTEN Regulation | 150 | 2.38e-04 | -0.174000 | 1.66e-03 |
| SARS-CoV-2 modulates autophagy | 11 | 3.19e-01 | -0.173000 | 4.81e-01 |
| VxPx cargo-targeting to cilium | 20 | 1.79e-01 | 0.173000 | 3.30e-01 |
| HDR through Homologous Recombination (HRR) | 65 | 1.57e-02 | -0.173000 | 5.55e-02 |
| Ethanol oxidation | 12 | 2.99e-01 | 0.173000 | 4.61e-01 |
| Protein folding | 96 | 3.38e-03 | -0.173000 | 1.59e-02 |
| Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function | 23 | 1.51e-01 | -0.173000 | 2.90e-01 |
| Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function | 23 | 1.51e-01 | -0.173000 | 2.90e-01 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | 23 | 1.51e-01 | -0.173000 | 2.90e-01 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | 23 | 1.51e-01 | -0.173000 | 2.90e-01 |
| Impaired BRCA2 binding to PALB2 | 23 | 1.51e-01 | -0.173000 | 2.90e-01 |
| Protein localization | 147 | 2.96e-04 | -0.173000 | 2.01e-03 |
| PI-3K cascade:FGFR1 | 21 | 1.71e-01 | -0.173000 | 3.18e-01 |
| Gene expression (Transcription) | 1407 | 1.19e-27 | -0.172000 | 3.04e-25 |
| Estrogen-dependent gene expression | 91 | 4.51e-03 | -0.172000 | 1.97e-02 |
| MAP2K and MAPK activation | 36 | 7.43e-02 | 0.172000 | 1.78e-01 |
| DNA Double-Strand Break Repair | 130 | 7.50e-04 | -0.171000 | 4.41e-03 |
| RNA Polymerase I Transcription Initiation | 42 | 5.51e-02 | -0.171000 | 1.44e-01 |
| Calcitonin-like ligand receptors | 10 | 3.50e-01 | -0.171000 | 5.17e-01 |
| Transferrin endocytosis and recycling | 30 | 1.06e-01 | -0.171000 | 2.28e-01 |
| ABC transporter disorders | 75 | 1.07e-02 | -0.170000 | 4.14e-02 |
| Triglyceride biosynthesis | 13 | 2.91e-01 | 0.169000 | 4.53e-01 |
| Ca-dependent events | 35 | 8.33e-02 | 0.169000 | 1.93e-01 |
| DNA Damage Bypass | 46 | 4.73e-02 | -0.169000 | 1.27e-01 |
| Beta-catenin independent WNT signaling | 144 | 4.60e-04 | -0.169000 | 2.97e-03 |
| EPHA-mediated growth cone collapse | 15 | 2.58e-01 | 0.169000 | 4.19e-01 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | 27 | 1.29e-01 | 0.169000 | 2.61e-01 |
| PKA activation | 18 | 2.17e-01 | 0.168000 | 3.74e-01 |
| Interactions of Rev with host cellular proteins | 35 | 8.63e-02 | -0.167000 | 1.97e-01 |
| Ion channel transport | 168 | 1.81e-04 | 0.167000 | 1.30e-03 |
| Purine catabolism | 17 | 2.33e-01 | -0.167000 | 3.93e-01 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | 25 | 1.49e-01 | -0.166000 | 2.90e-01 |
| RHOJ GTPase cycle | 51 | 3.99e-02 | 0.166000 | 1.13e-01 |
| PKA-mediated phosphorylation of CREB | 19 | 2.10e-01 | 0.166000 | 3.68e-01 |
| Transcription of E2F targets under negative control by DREAM complex | 19 | 2.11e-01 | -0.166000 | 3.68e-01 |
| SUMOylation of RNA binding proteins | 45 | 5.44e-02 | -0.166000 | 1.43e-01 |
| SUMOylation of DNA methylation proteins | 16 | 2.52e-01 | -0.165000 | 4.13e-01 |
| Synthesis of PE | 12 | 3.21e-01 | -0.165000 | 4.83e-01 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 25 | 1.53e-01 | -0.165000 | 2.92e-01 |
| Regulation of TLR by endogenous ligand | 17 | 2.38e-01 | 0.165000 | 4.00e-01 |
| Cell Cycle, Mitotic | 477 | 6.35e-10 | -0.165000 | 1.98e-08 |
| Apoptosis | 164 | 2.84e-04 | -0.164000 | 1.94e-03 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 44 | 5.98e-02 | -0.164000 | 1.52e-01 |
| Pyruvate metabolism | 29 | 1.28e-01 | -0.163000 | 2.60e-01 |
| RORA activates gene expression | 17 | 2.44e-01 | 0.163000 | 4.03e-01 |
| Vpr-mediated nuclear import of PICs | 32 | 1.10e-01 | -0.163000 | 2.35e-01 |
| RHOB GTPase cycle | 66 | 2.19e-02 | 0.163000 | 7.15e-02 |
| Transport of Mature Transcript to Cytoplasm | 76 | 1.42e-02 | -0.163000 | 5.19e-02 |
| Adenylate cyclase inhibitory pathway | 14 | 2.93e-01 | 0.162000 | 4.54e-01 |
| Recycling pathway of L1 | 23 | 1.80e-01 | 0.162000 | 3.31e-01 |
| Glutathione conjugation | 37 | 8.97e-02 | -0.161000 | 2.02e-01 |
| Metabolism of cofactors | 19 | 2.24e-01 | -0.161000 | 3.81e-01 |
| ERBB2 Activates PTK6 Signaling | 13 | 3.15e-01 | 0.161000 | 4.77e-01 |
| TCR signaling | 112 | 3.29e-03 | -0.161000 | 1.56e-02 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | 37 | 9.08e-02 | -0.161000 | 2.04e-01 |
| NEP/NS2 Interacts with the Cellular Export Machinery | 30 | 1.29e-01 | -0.160000 | 2.61e-01 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 117 | 2.80e-03 | 0.160000 | 1.37e-02 |
| CD209 (DC-SIGN) signaling | 20 | 2.17e-01 | 0.160000 | 3.74e-01 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | 41 | 7.79e-02 | -0.159000 | 1.85e-01 |
| Cell Cycle | 602 | 2.44e-11 | -0.159000 | 8.18e-10 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 11 | 3.62e-01 | -0.159000 | 5.29e-01 |
| Interactions of Vpr with host cellular proteins | 33 | 1.16e-01 | -0.158000 | 2.45e-01 |
| Regulation of TP53 Expression and Degradation | 37 | 9.67e-02 | -0.158000 | 2.13e-01 |
| Disorders of Developmental Biology | 11 | 3.65e-01 | -0.158000 | 5.30e-01 |
| Disorders of Nervous System Development | 11 | 3.65e-01 | -0.158000 | 5.30e-01 |
| Loss of function of MECP2 in Rett syndrome | 11 | 3.65e-01 | -0.158000 | 5.30e-01 |
| Pervasive developmental disorders | 11 | 3.65e-01 | -0.158000 | 5.30e-01 |
| M Phase | 336 | 6.59e-07 | -0.158000 | 9.68e-06 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | 20 | 2.23e-01 | -0.157000 | 3.80e-01 |
| PI Metabolism | 79 | 1.55e-02 | 0.157000 | 5.54e-02 |
| Lysosome Vesicle Biogenesis | 33 | 1.18e-01 | -0.157000 | 2.48e-01 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | 41 | 8.22e-02 | 0.157000 | 1.91e-01 |
| Signaling by RAS mutants | 41 | 8.22e-02 | 0.157000 | 1.91e-01 |
| Signaling by moderate kinase activity BRAF mutants | 41 | 8.22e-02 | 0.157000 | 1.91e-01 |
| Signaling downstream of RAS mutants | 41 | 8.22e-02 | 0.157000 | 1.91e-01 |
| Translesion synthesis by POLK | 17 | 2.64e-01 | -0.156000 | 4.25e-01 |
| Transcriptional regulation of pluripotent stem cells | 30 | 1.38e-01 | -0.156000 | 2.76e-01 |
| SUMOylation of DNA replication proteins | 44 | 7.28e-02 | -0.156000 | 1.75e-01 |
| Transcriptional Regulation by E2F6 | 32 | 1.27e-01 | -0.156000 | 2.59e-01 |
| Transport of the SLBP independent Mature mRNA | 33 | 1.22e-01 | -0.156000 | 2.53e-01 |
| mTORC1-mediated signalling | 23 | 1.96e-01 | -0.156000 | 3.50e-01 |
| Presynaptic nicotinic acetylcholine receptors | 12 | 3.51e-01 | -0.155000 | 5.18e-01 |
| Cholesterol biosynthesis | 24 | 1.88e-01 | -0.155000 | 3.40e-01 |
| RHOV GTPase cycle | 36 | 1.07e-01 | 0.155000 | 2.30e-01 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | 67 | 2.82e-02 | -0.155000 | 8.53e-02 |
| DNA strand elongation | 31 | 1.36e-01 | -0.155000 | 2.72e-01 |
| Amino acids regulate mTORC1 | 52 | 5.34e-02 | -0.155000 | 1.41e-01 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models | 22 | 2.09e-01 | -0.155000 | 3.67e-01 |
| Neurodegenerative Diseases | 22 | 2.09e-01 | -0.155000 | 3.67e-01 |
| Fanconi Anemia Pathway | 37 | 1.04e-01 | -0.154000 | 2.27e-01 |
| Mitochondrial calcium ion transport | 22 | 2.11e-01 | -0.154000 | 3.68e-01 |
| RHO GTPases activate KTN1 | 11 | 3.76e-01 | -0.154000 | 5.39e-01 |
| Defective GALNT12 causes CRCS1 | 18 | 2.58e-01 | 0.154000 | 4.19e-01 |
| Glycogen storage diseases | 14 | 3.18e-01 | -0.154000 | 4.81e-01 |
| Nuclear import of Rev protein | 32 | 1.32e-01 | -0.154000 | 2.66e-01 |
| Blood group systems biosynthesis | 22 | 2.12e-01 | 0.154000 | 3.69e-01 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 27 | 1.70e-01 | -0.153000 | 3.17e-01 |
| PKMTs methylate histone lysines | 37 | 1.10e-01 | 0.152000 | 2.35e-01 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | 74 | 2.40e-02 | -0.152000 | 7.47e-02 |
| Gluconeogenesis | 32 | 1.38e-01 | -0.152000 | 2.75e-01 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | 20 | 2.40e-01 | -0.152000 | 4.00e-01 |
| CaM pathway | 33 | 1.32e-01 | 0.151000 | 2.66e-01 |
| Calmodulin induced events | 33 | 1.32e-01 | 0.151000 | 2.66e-01 |
| Pyrimidine catabolism | 12 | 3.65e-01 | 0.151000 | 5.30e-01 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 34 | 1.29e-01 | -0.150000 | 2.61e-01 |
| Sensory processing of sound | 69 | 3.08e-02 | 0.150000 | 9.12e-02 |
| Nonhomologous End-Joining (NHEJ) | 32 | 1.41e-01 | -0.150000 | 2.79e-01 |
| NR1H2 and NR1H3-mediated signaling | 53 | 5.92e-02 | 0.150000 | 1.51e-01 |
| Plasma lipoprotein clearance | 37 | 1.15e-01 | -0.150000 | 2.43e-01 |
| Regulation of gene expression in beta cells | 21 | 2.37e-01 | -0.149000 | 3.97e-01 |
| Signaling by EGFR in Cancer | 25 | 1.97e-01 | -0.149000 | 3.50e-01 |
| Signaling by ERBB2 ECD mutants | 15 | 3.19e-01 | -0.149000 | 4.81e-01 |
| Signaling by FGFR1 | 49 | 7.23e-02 | -0.148000 | 1.75e-01 |
| Translesion synthesis by REV1 | 16 | 3.04e-01 | -0.148000 | 4.68e-01 |
| Nicotinate metabolism | 29 | 1.67e-01 | 0.148000 | 3.13e-01 |
| Interleukin receptor SHC signaling | 24 | 2.10e-01 | 0.148000 | 3.68e-01 |
| ISG15 antiviral mechanism | 71 | 3.13e-02 | -0.148000 | 9.25e-02 |
| Plasma lipoprotein assembly | 19 | 2.65e-01 | 0.148000 | 4.25e-01 |
| Synthesis of PIPs at the Golgi membrane | 17 | 2.93e-01 | 0.147000 | 4.54e-01 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | 31 | 1.58e-01 | -0.147000 | 2.99e-01 |
| SARS-CoV-2 Infection | 265 | 4.35e-05 | -0.146000 | 3.73e-04 |
| RND2 GTPase cycle | 42 | 1.03e-01 | 0.145000 | 2.24e-01 |
| RHOG GTPase cycle | 69 | 3.67e-02 | 0.145000 | 1.06e-01 |
| Acyl chain remodelling of PC | 26 | 2.00e-01 | 0.145000 | 3.54e-01 |
| Antiviral mechanism by IFN-stimulated genes | 78 | 2.66e-02 | -0.145000 | 8.10e-02 |
| Regulation of TP53 Degradation | 36 | 1.33e-01 | -0.145000 | 2.68e-01 |
| Signaling by BMP | 27 | 1.94e-01 | 0.144000 | 3.48e-01 |
| Telomere C-strand synthesis initiation | 11 | 4.07e-01 | -0.144000 | 5.72e-01 |
| Metabolism of nucleotides | 95 | 1.51e-02 | -0.144000 | 5.41e-02 |
| G alpha (i) signalling events | 306 | 1.44e-05 | 0.144000 | 1.36e-04 |
| Termination of O-glycan biosynthesis | 25 | 2.14e-01 | 0.143000 | 3.71e-01 |
| Carnitine metabolism | 11 | 4.11e-01 | 0.143000 | 5.75e-01 |
| Transport of Mature mRNA Derived from an Intronless Transcript | 40 | 1.17e-01 | -0.143000 | 2.46e-01 |
| FLT3 signaling in disease | 28 | 1.91e-01 | -0.143000 | 3.44e-01 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 28 | 1.91e-01 | 0.143000 | 3.44e-01 |
| Chylomicron assembly | 10 | 4.37e-01 | 0.142000 | 5.98e-01 |
| Condensation of Prophase Chromosomes | 12 | 3.94e-01 | -0.142000 | 5.58e-01 |
| Sensory processing of sound by outer hair cells of the cochlea | 49 | 8.56e-02 | 0.142000 | 1.96e-01 |
| AURKA Activation by TPX2 | 68 | 4.32e-02 | -0.142000 | 1.20e-01 |
| Biosynthesis of DHA-derived SPMs | 17 | 3.12e-01 | -0.142000 | 4.74e-01 |
| Metabolism of steroids | 148 | 2.91e-03 | 0.142000 | 1.41e-02 |
| Role of phospholipids in phagocytosis | 23 | 2.39e-01 | 0.142000 | 4.00e-01 |
| GPCR downstream signalling | 604 | 2.53e-09 | 0.142000 | 7.15e-08 |
| HCMV Late Events | 54 | 7.20e-02 | -0.141000 | 1.75e-01 |
| RHO GTPases Activate WASPs and WAVEs | 34 | 1.54e-01 | -0.141000 | 2.93e-01 |
| Extension of Telomeres | 48 | 9.03e-02 | -0.141000 | 2.03e-01 |
| Receptor-type tyrosine-protein phosphatases | 16 | 3.28e-01 | 0.141000 | 4.91e-01 |
| Metabolism of amine-derived hormones | 17 | 3.14e-01 | 0.141000 | 4.76e-01 |
| Lewis blood group biosynthesis | 18 | 3.02e-01 | 0.141000 | 4.65e-01 |
| ROS and RNS production in phagocytes | 35 | 1.50e-01 | -0.140000 | 2.90e-01 |
| FCERI mediated Ca+2 mobilization | 27 | 2.07e-01 | 0.140000 | 3.64e-01 |
| Regulation of beta-cell development | 41 | 1.20e-01 | -0.140000 | 2.50e-01 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 52 | 8.12e-02 | -0.140000 | 1.91e-01 |
| Defective C1GALT1C1 causes TNPS | 18 | 3.05e-01 | 0.140000 | 4.68e-01 |
| Glycogen synthesis | 15 | 3.51e-01 | -0.139000 | 5.18e-01 |
| HDACs deacetylate histones | 29 | 1.95e-01 | -0.139000 | 3.48e-01 |
| Dermatan sulfate biosynthesis | 10 | 4.47e-01 | -0.139000 | 6.06e-01 |
| Synthesis of substrates in N-glycan biosythesis | 60 | 6.29e-02 | -0.139000 | 1.58e-01 |
| Aggrephagy | 23 | 2.50e-01 | -0.138000 | 4.11e-01 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | 29 | 1.97e-01 | 0.138000 | 3.50e-01 |
| Trafficking of AMPA receptors | 29 | 1.97e-01 | 0.138000 | 3.50e-01 |
| activated TAK1 mediates p38 MAPK activation | 16 | 3.38e-01 | -0.138000 | 5.04e-01 |
| Signaling by CSF3 (G-CSF) | 28 | 2.05e-01 | -0.138000 | 3.62e-01 |
| Cellular Senescence | 130 | 6.54e-03 | -0.138000 | 2.74e-02 |
| HDR through MMEJ (alt-NHEJ) | 11 | 4.29e-01 | -0.138000 | 5.93e-01 |
| Sphingolipid de novo biosynthesis | 41 | 1.28e-01 | 0.137000 | 2.60e-01 |
| COPI-mediated anterograde transport | 83 | 3.04e-02 | -0.137000 | 9.06e-02 |
| Activated NTRK2 signals through FRS2 and FRS3 | 11 | 4.31e-01 | -0.137000 | 5.93e-01 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | 101 | 1.73e-02 | 0.137000 | 5.96e-02 |
| Reversible hydration of carbon dioxide | 11 | 4.32e-01 | -0.137000 | 5.94e-01 |
| Integrin signaling | 27 | 2.19e-01 | 0.137000 | 3.76e-01 |
| Resolution of D-Loop Structures | 32 | 1.81e-01 | -0.137000 | 3.32e-01 |
| Signaling by the B Cell Receptor (BCR) | 105 | 1.56e-02 | -0.137000 | 5.54e-02 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | 15 | 3.60e-01 | -0.136000 | 5.28e-01 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | 15 | 3.62e-01 | 0.136000 | 5.29e-01 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 94 | 2.29e-02 | -0.136000 | 7.26e-02 |
| Toll Like Receptor 2 (TLR2) Cascade | 94 | 2.29e-02 | -0.136000 | 7.26e-02 |
| Toll Like Receptor TLR1:TLR2 Cascade | 94 | 2.29e-02 | -0.136000 | 7.26e-02 |
| Toll Like Receptor TLR6:TLR2 Cascade | 94 | 2.29e-02 | -0.136000 | 7.26e-02 |
| Assembly of collagen fibrils and other multimeric structures | 56 | 7.91e-02 | 0.136000 | 1.87e-01 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | 11 | 4.37e-01 | 0.135000 | 5.98e-01 |
| G alpha (q) signalling events | 206 | 8.04e-04 | 0.135000 | 4.66e-03 |
| Aflatoxin activation and detoxification | 20 | 2.96e-01 | -0.135000 | 4.57e-01 |
| FRS-mediated FGFR1 signaling | 23 | 2.63e-01 | -0.135000 | 4.25e-01 |
| SARS-CoV Infections | 339 | 1.94e-05 | -0.135000 | 1.78e-04 |
| Citric acid cycle (TCA cycle) | 21 | 2.85e-01 | -0.135000 | 4.47e-01 |
| Post-chaperonin tubulin folding pathway | 23 | 2.64e-01 | -0.134000 | 4.25e-01 |
| Platelet degranulation | 116 | 1.24e-02 | 0.134000 | 4.69e-02 |
| Infection with Mycobacterium tuberculosis | 26 | 2.36e-01 | -0.134000 | 3.97e-01 |
| RHOA GTPase cycle | 140 | 6.19e-03 | 0.134000 | 2.62e-02 |
| Caspase activation via extrinsic apoptotic signalling pathway | 25 | 2.47e-01 | -0.134000 | 4.07e-01 |
| Hedgehog ‘off’ state | 97 | 2.28e-02 | -0.134000 | 7.26e-02 |
| Infectious disease | 885 | 1.28e-11 | -0.134000 | 4.45e-10 |
| G beta:gamma signalling through BTK | 17 | 3.40e-01 | -0.134000 | 5.06e-01 |
| Sensory processing of sound by inner hair cells of the cochlea | 62 | 6.90e-02 | 0.133000 | 1.69e-01 |
| Triglyceride metabolism | 36 | 1.66e-01 | 0.133000 | 3.11e-01 |
| HS-GAG biosynthesis | 28 | 2.24e-01 | 0.133000 | 3.81e-01 |
| Signaling by NTRK3 (TRKC) | 17 | 3.43e-01 | -0.133000 | 5.09e-01 |
| Suppression of phagosomal maturation | 13 | 4.07e-01 | -0.133000 | 5.72e-01 |
| FOXO-mediated transcription of cell death genes | 15 | 3.74e-01 | -0.133000 | 5.37e-01 |
| RHO GTPases Activate Formins | 114 | 1.46e-02 | -0.132000 | 5.27e-02 |
| Fatty acids | 15 | 3.76e-01 | -0.132000 | 5.39e-01 |
| MAP kinase activation | 58 | 8.37e-02 | -0.131000 | 1.94e-01 |
| Acetylcholine Neurotransmitter Release Cycle | 16 | 3.63e-01 | -0.131000 | 5.30e-01 |
| Regulation of HSF1-mediated heat shock response | 78 | 4.51e-02 | -0.131000 | 1.25e-01 |
| Mismatch Repair | 15 | 3.79e-01 | -0.131000 | 5.42e-01 |
| Regulation of TP53 Activity through Methylation | 18 | 3.36e-01 | -0.131000 | 5.02e-01 |
| Xenobiotics | 24 | 2.67e-01 | 0.131000 | 4.28e-01 |
| Termination of translesion DNA synthesis | 31 | 2.12e-01 | -0.130000 | 3.68e-01 |
| Acyl chain remodelling of PI | 16 | 3.70e-01 | 0.130000 | 5.35e-01 |
| Mitotic Spindle Checkpoint | 106 | 2.14e-02 | -0.129000 | 7.04e-02 |
| Energy dependent regulation of mTOR by LKB1-AMPK | 28 | 2.37e-01 | -0.129000 | 3.97e-01 |
| Signaling by WNT | 263 | 3.17e-04 | -0.129000 | 2.14e-03 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | 25 | 2.65e-01 | -0.129000 | 4.25e-01 |
| Glycolysis | 68 | 6.68e-02 | -0.129000 | 1.65e-01 |
| Signaling by cytosolic FGFR1 fusion mutants | 17 | 3.60e-01 | 0.128000 | 5.28e-01 |
| Cell death signalling via NRAGE, NRIF and NADE | 69 | 6.58e-02 | 0.128000 | 1.63e-01 |
| SUMOylation of transcription cofactors | 43 | 1.47e-01 | -0.128000 | 2.87e-01 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 10 | 4.84e-01 | -0.128000 | 6.39e-01 |
| DNA Double Strand Break Response | 42 | 1.54e-01 | -0.127000 | 2.93e-01 |
| Cellular response to heat stress | 95 | 3.23e-02 | -0.127000 | 9.50e-02 |
| Processing of SMDT1 | 15 | 3.94e-01 | -0.127000 | 5.58e-01 |
| Regulation of signaling by CBL | 18 | 3.54e-01 | 0.126000 | 5.20e-01 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | 31 | 2.24e-01 | -0.126000 | 3.81e-01 |
| Maturation of nucleoprotein | 11 | 4.69e-01 | -0.126000 | 6.26e-01 |
| Attenuation phase | 25 | 2.75e-01 | -0.126000 | 4.36e-01 |
| MAPK3 (ERK1) activation | 10 | 4.91e-01 | -0.126000 | 6.44e-01 |
| Regulation of IFNA/IFNB signaling | 24 | 2.86e-01 | -0.126000 | 4.48e-01 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 14 | 4.16e-01 | -0.125000 | 5.79e-01 |
| Deposition of new CENPA-containing nucleosomes at the centromere | 26 | 2.70e-01 | -0.125000 | 4.30e-01 |
| Nucleosome assembly | 26 | 2.70e-01 | -0.125000 | 4.30e-01 |
| Ion homeostasis | 50 | 1.26e-01 | 0.125000 | 2.59e-01 |
| NOTCH1 Intracellular Domain Regulates Transcription | 44 | 1.53e-01 | -0.125000 | 2.92e-01 |
| Beta-catenin phosphorylation cascade | 16 | 3.89e-01 | -0.124000 | 5.54e-01 |
| Response to elevated platelet cytosolic Ca2+ | 121 | 1.86e-02 | 0.124000 | 6.34e-02 |
| RAS processing | 19 | 3.51e-01 | -0.124000 | 5.18e-01 |
| Metabolism of fat-soluble vitamins | 46 | 1.47e-01 | 0.123000 | 2.87e-01 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | 41 | 1.72e-01 | -0.123000 | 3.20e-01 |
| Phase 0 - rapid depolarisation | 31 | 2.37e-01 | 0.123000 | 3.97e-01 |
| Tandem pore domain potassium channels | 12 | 4.61e-01 | -0.123000 | 6.18e-01 |
| Negative regulation of FGFR3 signaling | 28 | 2.61e-01 | -0.123000 | 4.23e-01 |
| Signaling by NOTCH | 183 | 4.24e-03 | -0.122000 | 1.89e-02 |
| Glucose metabolism | 87 | 4.83e-02 | -0.122000 | 1.29e-01 |
| Advanced glycosylation endproduct receptor signaling | 13 | 4.46e-01 | -0.122000 | 6.06e-01 |
| Activation of the pre-replicative complex | 31 | 2.40e-01 | -0.122000 | 4.00e-01 |
| RND1 GTPase cycle | 41 | 1.77e-01 | 0.122000 | 3.28e-01 |
| Ephrin signaling | 17 | 3.85e-01 | 0.122000 | 5.50e-01 |
| Reduction of cytosolic Ca++ levels | 11 | 4.85e-01 | 0.122000 | 6.39e-01 |
| Asparagine N-linked glycosylation | 278 | 4.84e-04 | -0.121000 | 3.10e-03 |
| Oncogenic MAPK signaling | 76 | 6.72e-02 | 0.121000 | 1.65e-01 |
| Nuclear events stimulated by ALK signaling in cancer | 18 | 3.73e-01 | -0.121000 | 5.37e-01 |
| Neurotransmitter release cycle | 47 | 1.51e-01 | -0.121000 | 2.90e-01 |
| Regulation of PLK1 Activity at G2/M Transition | 83 | 5.67e-02 | -0.121000 | 1.47e-01 |
| Programmed Cell Death | 192 | 3.92e-03 | -0.121000 | 1.78e-02 |
| Toll-like Receptor Cascades | 143 | 1.30e-02 | -0.120000 | 4.85e-02 |
| Toll Like Receptor 4 (TLR4) Cascade | 124 | 2.10e-02 | -0.120000 | 6.99e-02 |
| Signaling by Retinoic Acid | 41 | 1.85e-01 | -0.120000 | 3.38e-01 |
| Potential therapeutics for SARS | 83 | 6.01e-02 | -0.119000 | 1.53e-01 |
| Resolution of Sister Chromatid Cohesion | 98 | 4.29e-02 | -0.118000 | 1.20e-01 |
| Translation of Structural Proteins | 29 | 2.71e-01 | -0.118000 | 4.32e-01 |
| ESR-mediated signaling | 160 | 9.99e-03 | -0.118000 | 3.91e-02 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | 15 | 4.30e-01 | -0.118000 | 5.93e-01 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | 15 | 4.30e-01 | -0.118000 | 5.93e-01 |
| Negative regulation of FGFR2 signaling | 33 | 2.43e-01 | -0.117000 | 4.03e-01 |
| MyD88 deficiency (TLR2/4) | 16 | 4.18e-01 | 0.117000 | 5.82e-01 |
| Pentose phosphate pathway | 12 | 4.86e-01 | -0.116000 | 6.39e-01 |
| Reactions specific to the complex N-glycan synthesis pathway | 10 | 5.25e-01 | 0.116000 | 6.76e-01 |
| Metabolism of proteins | 1774 | 2.68e-16 | -0.116000 | 1.21e-14 |
| Uptake and function of anthrax toxins | 11 | 5.05e-01 | 0.116000 | 6.58e-01 |
| Downstream signaling of activated FGFR1 | 31 | 2.63e-01 | -0.116000 | 4.25e-01 |
| RAC2 GTPase cycle | 80 | 7.28e-02 | 0.116000 | 1.75e-01 |
| Pyroptosis | 26 | 3.07e-01 | 0.116000 | 4.69e-01 |
| Diseases associated with glycosaminoglycan metabolism | 38 | 2.17e-01 | 0.116000 | 3.74e-01 |
| MTOR signalling | 40 | 2.06e-01 | -0.115000 | 3.64e-01 |
| Signaling by FGFR3 | 39 | 2.13e-01 | -0.115000 | 3.70e-01 |
| Removal of the Flap Intermediate from the C-strand | 17 | 4.12e-01 | -0.115000 | 5.76e-01 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | 77 | 8.15e-02 | -0.115000 | 1.91e-01 |
| Signalling to ERKs | 34 | 2.47e-01 | -0.115000 | 4.07e-01 |
| Nucleotide salvage | 21 | 3.63e-01 | -0.115000 | 5.30e-01 |
| Cardiac conduction | 120 | 3.05e-02 | 0.114000 | 9.06e-02 |
| Acetylcholine binding and downstream events | 14 | 4.59e-01 | -0.114000 | 6.17e-01 |
| Postsynaptic nicotinic acetylcholine receptors | 14 | 4.59e-01 | -0.114000 | 6.17e-01 |
| RHO GTPases activate PAKs | 19 | 3.89e-01 | 0.114000 | 5.54e-01 |
| Prolactin receptor signaling | 15 | 4.47e-01 | 0.113000 | 6.06e-01 |
| Triglyceride catabolism | 23 | 3.48e-01 | 0.113000 | 5.15e-01 |
| Mitotic Prometaphase | 175 | 9.95e-03 | -0.113000 | 3.91e-02 |
| G beta:gamma signalling through CDC42 | 19 | 3.94e-01 | -0.113000 | 5.58e-01 |
| Protein ubiquitination | 61 | 1.28e-01 | -0.113000 | 2.60e-01 |
| Presynaptic function of Kainate receptors | 21 | 3.74e-01 | -0.112000 | 5.37e-01 |
| TGF-beta receptor signaling activates SMADs | 45 | 1.93e-01 | -0.112000 | 3.48e-01 |
| Regulation of KIT signaling | 16 | 4.38e-01 | 0.112000 | 5.99e-01 |
| Loss of Nlp from mitotic centrosomes | 65 | 1.19e-01 | -0.112000 | 2.48e-01 |
| Loss of proteins required for interphase microtubule organization from the centrosome | 65 | 1.19e-01 | -0.112000 | 2.48e-01 |
| Phospholipid metabolism | 192 | 7.53e-03 | 0.112000 | 3.11e-02 |
| Nucleotide-like (purinergic) receptors | 13 | 4.86e-01 | 0.112000 | 6.39e-01 |
| Biosynthesis of specialized proresolving mediators (SPMs) | 19 | 4.02e-01 | -0.111000 | 5.66e-01 |
| Telomere C-strand (Lagging Strand) Synthesis | 32 | 2.77e-01 | -0.111000 | 4.38e-01 |
| SHC1 events in ERBB2 signaling | 22 | 3.68e-01 | 0.111000 | 5.33e-01 |
| Plasma lipoprotein remodeling | 32 | 2.78e-01 | 0.111000 | 4.38e-01 |
| Signal transduction by L1 | 20 | 3.92e-01 | 0.110000 | 5.57e-01 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | 30 | 2.96e-01 | -0.110000 | 4.57e-01 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | 30 | 2.96e-01 | -0.110000 | 4.57e-01 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | 89 | 7.25e-02 | -0.110000 | 1.75e-01 |
| Amplification of signal from the kinetochores | 89 | 7.25e-02 | -0.110000 | 1.75e-01 |
| Interleukin-17 signaling | 66 | 1.24e-01 | -0.110000 | 2.56e-01 |
| Budding and maturation of HIV virion | 28 | 3.16e-01 | -0.110000 | 4.77e-01 |
| Basigin interactions | 24 | 3.54e-01 | -0.109000 | 5.20e-01 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 14 | 4.79e-01 | -0.109000 | 6.35e-01 |
| Regulation of PTEN mRNA translation | 25 | 3.44e-01 | 0.109000 | 5.11e-01 |
| Regulated Necrosis | 53 | 1.69e-01 | -0.109000 | 3.17e-01 |
| Interleukin-1 family signaling | 134 | 3.06e-02 | -0.108000 | 9.08e-02 |
| Signaling by VEGF | 101 | 6.03e-02 | 0.108000 | 1.53e-01 |
| Recognition of DNA damage by PCNA-containing replication complex | 29 | 3.14e-01 | -0.108000 | 4.76e-01 |
| Muscle contraction | 186 | 1.11e-02 | 0.108000 | 4.27e-02 |
| Incretin synthesis, secretion, and inactivation | 23 | 3.71e-01 | -0.108000 | 5.36e-01 |
| Metabolism of folate and pterines | 16 | 4.57e-01 | -0.107000 | 6.16e-01 |
| HCMV Infection | 79 | 9.96e-02 | -0.107000 | 2.19e-01 |
| Glucagon signaling in metabolic regulation | 33 | 2.87e-01 | 0.107000 | 4.48e-01 |
| Polymerase switching on the C-strand of the telomere | 24 | 3.64e-01 | -0.107000 | 5.30e-01 |
| Unblocking of NMDA receptors, glutamate binding and activation | 19 | 4.21e-01 | 0.107000 | 5.84e-01 |
| DSCAM interactions | 11 | 5.41e-01 | 0.106000 | 6.90e-01 |
| Signaling by TGF-beta Receptor Complex | 86 | 8.77e-02 | -0.106000 | 1.99e-01 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | 31 | 3.05e-01 | -0.106000 | 4.68e-01 |
| MET receptor recycling | 10 | 5.60e-01 | -0.106000 | 7.09e-01 |
| Negative regulation of FGFR4 signaling | 30 | 3.15e-01 | -0.106000 | 4.77e-01 |
| Defective GALNT3 causes HFTC | 18 | 4.37e-01 | 0.106000 | 5.98e-01 |
| FCGR activation | 12 | 5.27e-01 | 0.105000 | 6.77e-01 |
| Tie2 Signaling | 18 | 4.39e-01 | 0.105000 | 5.99e-01 |
| Transcriptional regulation by RUNX1 | 183 | 1.39e-02 | -0.105000 | 5.13e-02 |
| Passive transport by Aquaporins | 13 | 5.11e-01 | 0.105000 | 6.64e-01 |
| Interleukin-2 family signaling | 40 | 2.50e-01 | 0.105000 | 4.11e-01 |
| Response of Mtb to phagocytosis | 22 | 3.95e-01 | -0.105000 | 5.58e-01 |
| Chaperone Mediated Autophagy | 19 | 4.29e-01 | -0.105000 | 5.93e-01 |
| Signaling by GPCR | 671 | 3.44e-06 | 0.105000 | 3.98e-05 |
| TRAF6 mediated IRF7 activation | 28 | 3.38e-01 | -0.105000 | 5.04e-01 |
| Peptide ligand-binding receptors | 190 | 1.29e-02 | 0.104000 | 4.84e-02 |
| Interleukin-10 signaling | 45 | 2.26e-01 | 0.104000 | 3.83e-01 |
| Signaling by FGFR4 | 40 | 2.54e-01 | -0.104000 | 4.14e-01 |
| ADP signalling through P2Y purinoceptor 12 | 22 | 3.98e-01 | -0.104000 | 5.62e-01 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 54 | 1.86e-01 | -0.104000 | 3.38e-01 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | 54 | 1.86e-01 | -0.104000 | 3.38e-01 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 54 | 1.86e-01 | -0.104000 | 3.38e-01 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | 54 | 1.86e-01 | -0.104000 | 3.38e-01 |
| Signaling by NOTCH1 in Cancer | 54 | 1.86e-01 | -0.104000 | 3.38e-01 |
| RUNX2 regulates bone development | 29 | 3.33e-01 | -0.104000 | 4.98e-01 |
| Downregulation of ERBB2 signaling | 28 | 3.42e-01 | -0.104000 | 5.08e-01 |
| Butyrophilin (BTN) family interactions | 12 | 5.34e-01 | 0.104000 | 6.85e-01 |
| Caspase-mediated cleavage of cytoskeletal proteins | 12 | 5.35e-01 | -0.103000 | 6.85e-01 |
| RHOC GTPase cycle | 69 | 1.37e-01 | 0.103000 | 2.75e-01 |
| Cargo recognition for clathrin-mediated endocytosis | 98 | 7.75e-02 | -0.103000 | 1.85e-01 |
| HSF1-dependent transactivation | 35 | 2.92e-01 | -0.103000 | 4.54e-01 |
| RET signaling | 41 | 2.56e-01 | -0.102000 | 4.17e-01 |
| Interleukin-6 family signaling | 24 | 3.85e-01 | -0.102000 | 5.50e-01 |
| SUMOylation of chromatin organization proteins | 54 | 1.94e-01 | -0.102000 | 3.48e-01 |
| TBC/RABGAPs | 42 | 2.52e-01 | -0.102000 | 4.12e-01 |
| Repression of WNT target genes | 13 | 5.24e-01 | -0.102000 | 6.76e-01 |
| G beta:gamma signalling through PLC beta | 20 | 4.30e-01 | -0.102000 | 5.93e-01 |
| PPARA activates gene expression | 114 | 6.12e-02 | 0.101000 | 1.55e-01 |
| RHOH GTPase cycle | 36 | 2.93e-01 | -0.101000 | 4.54e-01 |
| Fc epsilon receptor (FCERI) signaling | 126 | 4.98e-02 | -0.101000 | 1.33e-01 |
| Signaling by Leptin | 11 | 5.63e-01 | -0.101000 | 7.11e-01 |
| Insulin processing | 26 | 3.74e-01 | 0.101000 | 5.37e-01 |
| ABC-family proteins mediated transport | 98 | 8.57e-02 | -0.100000 | 1.96e-01 |
| Nicotinamide salvaging | 17 | 4.73e-01 | 0.100000 | 6.30e-01 |
| Inactivation of CSF3 (G-CSF) signaling | 23 | 4.05e-01 | -0.100000 | 5.69e-01 |
| Dual Incision in GG-NER | 39 | 2.78e-01 | -0.100000 | 4.38e-01 |
| Platelet homeostasis | 85 | 1.11e-01 | 0.099900 | 2.37e-01 |
| Processive synthesis on the C-strand of the telomere | 19 | 4.51e-01 | -0.099800 | 6.10e-01 |
| PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | 14 | 5.18e-01 | 0.099700 | 6.69e-01 |
| ER to Golgi Anterograde Transport | 134 | 4.64e-02 | -0.099600 | 1.26e-01 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | 20 | 4.42e-01 | 0.099400 | 6.01e-01 |
| Removal of the Flap Intermediate | 13 | 5.35e-01 | -0.099300 | 6.85e-01 |
| Oxidative Stress Induced Senescence | 66 | 1.63e-01 | -0.099200 | 3.07e-01 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | 43 | 2.64e-01 | 0.098500 | 4.25e-01 |
| Interleukin-4 and Interleukin-13 signaling | 104 | 8.39e-02 | -0.098000 | 1.94e-01 |
| HATs acetylate histones | 71 | 1.53e-01 | -0.098000 | 2.92e-01 |
| Fatty acyl-CoA biosynthesis | 35 | 3.19e-01 | 0.097300 | 4.81e-01 |
| Constitutive Signaling by EGFRvIII | 15 | 5.16e-01 | -0.096800 | 6.68e-01 |
| Signaling by EGFRvIII in Cancer | 15 | 5.16e-01 | -0.096800 | 6.68e-01 |
| trans-Golgi Network Vesicle Budding | 67 | 1.72e-01 | -0.096300 | 3.20e-01 |
| Signaling by Hedgehog | 133 | 5.51e-02 | -0.096300 | 1.44e-01 |
| Integration of energy metabolism | 106 | 8.67e-02 | 0.096200 | 1.97e-01 |
| Interleukin-20 family signaling | 25 | 4.05e-01 | 0.096100 | 5.70e-01 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | 41 | 2.90e-01 | 0.095400 | 4.53e-01 |
| MET activates RAP1 and RAC1 | 11 | 5.84e-01 | 0.095200 | 7.32e-01 |
| GRB2 events in EGFR signaling | 13 | 5.52e-01 | 0.095200 | 7.03e-01 |
| RHO GTPase cycle | 421 | 8.45e-04 | 0.094700 | 4.86e-03 |
| Transport of Ribonucleoproteins into the Host Nucleus | 30 | 3.73e-01 | -0.093900 | 5.37e-01 |
| COPI-dependent Golgi-to-ER retrograde traffic | 81 | 1.44e-01 | -0.093800 | 2.83e-01 |
| SUMOylation | 164 | 3.83e-02 | -0.093700 | 1.09e-01 |
| E3 ubiquitin ligases ubiquitinate target proteins | 43 | 2.92e-01 | -0.092800 | 4.54e-01 |
| PECAM1 interactions | 12 | 5.78e-01 | 0.092700 | 7.26e-01 |
| Inositol phosphate metabolism | 45 | 2.83e-01 | 0.092600 | 4.43e-01 |
| Nuclear Pore Complex (NPC) Disassembly | 34 | 3.51e-01 | -0.092400 | 5.18e-01 |
| Clathrin-mediated endocytosis | 135 | 6.44e-02 | -0.092100 | 1.61e-01 |
| Transcriptional Regulation by VENTX | 41 | 3.08e-01 | -0.091900 | 4.70e-01 |
| CTLA4 inhibitory signaling | 21 | 4.67e-01 | 0.091800 | 6.23e-01 |
| NOD1/2 Signaling Pathway | 29 | 3.92e-01 | -0.091800 | 5.57e-01 |
| VEGFA-VEGFR2 Pathway | 93 | 1.26e-01 | 0.091700 | 2.59e-01 |
| Regulation of lipid metabolism by PPARalpha | 116 | 8.94e-02 | 0.091200 | 2.02e-01 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | 13 | 5.69e-01 | 0.091100 | 7.18e-01 |
| HSF1 activation | 27 | 4.13e-01 | -0.091000 | 5.76e-01 |
| HCMV Early Events | 55 | 2.45e-01 | -0.090600 | 4.04e-01 |
| Platelet calcium homeostasis | 27 | 4.16e-01 | 0.090500 | 5.79e-01 |
| Class A/1 (Rhodopsin-like receptors) | 312 | 5.97e-03 | 0.090400 | 2.55e-02 |
| Cargo concentration in the ER | 32 | 3.76e-01 | -0.090400 | 5.39e-01 |
| Long-term potentiation | 22 | 4.64e-01 | 0.090200 | 6.20e-01 |
| Prolonged ERK activation events | 14 | 5.60e-01 | 0.089900 | 7.09e-01 |
| Signaling by FGFR in disease | 61 | 2.26e-01 | -0.089600 | 3.83e-01 |
| Processive synthesis on the lagging strand | 14 | 5.62e-01 | -0.089500 | 7.10e-01 |
| Na+/Cl- dependent neurotransmitter transporters | 18 | 5.11e-01 | 0.089500 | 6.64e-01 |
| Axon guidance | 503 | 5.99e-04 | -0.089200 | 3.65e-03 |
| Signaling by ERBB2 in Cancer | 25 | 4.40e-01 | -0.089100 | 6.00e-01 |
| N-glycan antennae elongation in the medial/trans-Golgi | 26 | 4.32e-01 | 0.089000 | 5.94e-01 |
| COPII-mediated vesicle transport | 66 | 2.12e-01 | -0.088900 | 3.68e-01 |
| SUMO E3 ligases SUMOylate target proteins | 158 | 5.40e-02 | -0.088800 | 1.42e-01 |
| Signaling by PDGF | 52 | 2.70e-01 | 0.088400 | 4.30e-01 |
| Heme signaling | 45 | 3.05e-01 | 0.088300 | 4.68e-01 |
| Regulation of FZD by ubiquitination | 21 | 4.85e-01 | -0.088100 | 6.39e-01 |
| Apoptotic cleavage of cellular proteins | 35 | 3.67e-01 | 0.088000 | 5.32e-01 |
| Signaling by NODAL | 22 | 4.75e-01 | -0.087900 | 6.31e-01 |
| Hemostasis | 560 | 3.82e-04 | 0.087600 | 2.52e-03 |
| Mitotic Prophase | 78 | 1.82e-01 | -0.087400 | 3.33e-01 |
| Regulation of RUNX1 Expression and Activity | 25 | 4.50e-01 | -0.087300 | 6.09e-01 |
| Meiotic recombination | 26 | 4.42e-01 | -0.087100 | 6.01e-01 |
| Growth hormone receptor signaling | 24 | 4.60e-01 | -0.087100 | 6.18e-01 |
| Semaphorin interactions | 61 | 2.40e-01 | 0.087000 | 4.00e-01 |
| Thromboxane signalling through TP receptor | 24 | 4.62e-01 | -0.086700 | 6.18e-01 |
| TAK1-dependent IKK and NF-kappa-B activation | 25 | 4.53e-01 | -0.086600 | 6.12e-01 |
| PCNA-Dependent Long Patch Base Excision Repair | 21 | 4.92e-01 | -0.086600 | 6.45e-01 |
| CYP2E1 reactions | 11 | 6.20e-01 | -0.086400 | 7.65e-01 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 16 | 5.50e-01 | -0.086300 | 7.00e-01 |
| Signaling by Interleukins | 426 | 2.22e-03 | -0.086300 | 1.15e-02 |
| Physiological factors | 12 | 6.06e-01 | -0.086000 | 7.52e-01 |
| SARS-CoV-1 Infection | 51 | 2.88e-01 | -0.086000 | 4.49e-01 |
| Platelet activation, signaling and aggregation | 246 | 2.02e-02 | 0.085900 | 6.76e-02 |
| RHO GTPases activate CIT | 19 | 5.18e-01 | -0.085700 | 6.69e-01 |
| Recruitment of NuMA to mitotic centrosomes | 76 | 1.96e-01 | -0.085700 | 3.50e-01 |
| Eicosanoids | 12 | 6.09e-01 | 0.085300 | 7.53e-01 |
| Activation of BH3-only proteins | 30 | 4.19e-01 | -0.085200 | 5.82e-01 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 18 | 5.32e-01 | -0.085000 | 6.83e-01 |
| G alpha (s) signalling events | 153 | 7.07e-02 | 0.084600 | 1.72e-01 |
| Cargo trafficking to the periciliary membrane | 49 | 3.06e-01 | -0.084500 | 4.68e-01 |
| C-type lectin receptors (CLRs) | 137 | 8.80e-02 | -0.084400 | 1.99e-01 |
| CaMK IV-mediated phosphorylation of CREB | 10 | 6.44e-01 | -0.084300 | 7.78e-01 |
| Platelet Aggregation (Plug Formation) | 37 | 3.77e-01 | 0.084000 | 5.39e-01 |
| E2F mediated regulation of DNA replication | 20 | 5.16e-01 | 0.083800 | 6.68e-01 |
| Signaling by TGFB family members | 114 | 1.22e-01 | -0.083800 | 2.53e-01 |
| mitochondrial fatty acid beta-oxidation of saturated fatty acids | 11 | 6.31e-01 | 0.083600 | 7.72e-01 |
| Interleukin-27 signaling | 11 | 6.32e-01 | -0.083300 | 7.72e-01 |
| Eicosanoid ligand-binding receptors | 14 | 5.90e-01 | 0.083200 | 7.38e-01 |
| SHC-mediated cascade:FGFR2 | 22 | 5.00e-01 | -0.083000 | 6.54e-01 |
| FGFR2b ligand binding and activation | 10 | 6.50e-01 | 0.082800 | 7.84e-01 |
| Metabolism of nitric oxide: NOS3 activation and regulation | 15 | 5.80e-01 | -0.082500 | 7.28e-01 |
| NS1 Mediated Effects on Host Pathways | 39 | 3.73e-01 | -0.082400 | 5.37e-01 |
| EML4 and NUDC in mitotic spindle formation | 93 | 1.70e-01 | -0.082300 | 3.17e-01 |
| SHC-mediated cascade:FGFR3 | 17 | 5.59e-01 | -0.081900 | 7.08e-01 |
| Pyrimidine salvage | 10 | 6.54e-01 | -0.081900 | 7.87e-01 |
| Phase II - Conjugation of compounds | 109 | 1.40e-01 | 0.081800 | 2.77e-01 |
| Gap junction degradation | 10 | 6.56e-01 | 0.081400 | 7.88e-01 |
| Reproduction | 82 | 2.03e-01 | 0.081300 | 3.59e-01 |
| Centrosome maturation | 77 | 2.20e-01 | -0.080900 | 3.76e-01 |
| Recruitment of mitotic centrosome proteins and complexes | 77 | 2.20e-01 | -0.080900 | 3.76e-01 |
| RHOBTB1 GTPase cycle | 22 | 5.12e-01 | -0.080800 | 6.64e-01 |
| SLC-mediated transmembrane transport | 238 | 3.24e-02 | 0.080400 | 9.51e-02 |
| PIP3 activates AKT signaling | 275 | 2.20e-02 | -0.080100 | 7.15e-02 |
| Defects in vitamin and cofactor metabolism | 20 | 5.36e-01 | -0.080000 | 6.85e-01 |
| Nervous system development | 527 | 1.71e-03 | -0.079700 | 9.22e-03 |
| Mitotic Telophase/Cytokinesis | 10 | 6.63e-01 | 0.079600 | 7.91e-01 |
| MASTL Facilitates Mitotic Progression | 10 | 6.64e-01 | -0.079400 | 7.91e-01 |
| Negative regulation of MET activity | 20 | 5.42e-01 | 0.078800 | 6.91e-01 |
| Gastrin-CREB signalling pathway via PKC and MAPK | 17 | 5.74e-01 | 0.078800 | 7.22e-01 |
| Antigen processing: Ubiquitination & Proteasome degradation | 293 | 2.10e-02 | -0.078300 | 6.99e-02 |
| RAC3 GTPase cycle | 84 | 2.17e-01 | 0.077800 | 3.74e-01 |
| Synthesis of IP3 and IP4 in the cytosol | 25 | 5.03e-01 | 0.077400 | 6.57e-01 |
| Regulation of insulin secretion | 77 | 2.41e-01 | 0.077300 | 4.00e-01 |
| FLT3 Signaling | 38 | 4.12e-01 | -0.076900 | 5.76e-01 |
| Phospholipase C-mediated cascade; FGFR2 | 17 | 5.83e-01 | -0.076800 | 7.31e-01 |
| RHO GTPases activate PKNs | 34 | 4.40e-01 | -0.076400 | 6.00e-01 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 38 | 4.15e-01 | -0.076300 | 5.79e-01 |
| RUNX3 regulates NOTCH signaling | 13 | 6.34e-01 | 0.076300 | 7.72e-01 |
| RAF activation | 33 | 4.49e-01 | 0.076200 | 6.08e-01 |
| Metabolism of lipids | 696 | 5.96e-04 | 0.076100 | 3.64e-03 |
| NCAM signaling for neurite out-growth | 57 | 3.20e-01 | 0.076100 | 4.82e-01 |
| Disease | 1624 | 2.87e-07 | -0.075900 | 4.38e-06 |
| Ovarian tumor domain proteases | 36 | 4.31e-01 | -0.075800 | 5.93e-01 |
| Neurotransmitter receptors and postsynaptic signal transmission | 175 | 8.47e-02 | 0.075500 | 1.95e-01 |
| Regulation of BACH1 activity | 15 | 6.13e-01 | -0.075500 | 7.57e-01 |
| p75 NTR receptor-mediated signalling | 89 | 2.19e-01 | 0.075300 | 3.76e-01 |
| Transport to the Golgi and subsequent modification | 165 | 9.50e-02 | -0.075300 | 2.11e-01 |
| Signal attenuation | 10 | 6.81e-01 | -0.075200 | 8.01e-01 |
| Formation of the beta-catenin:TCF transactivating complex | 32 | 4.62e-01 | -0.075100 | 6.18e-01 |
| Anchoring of the basal body to the plasma membrane | 92 | 2.14e-01 | -0.075000 | 3.71e-01 |
| Gap junction trafficking and regulation | 29 | 4.85e-01 | 0.075000 | 6.39e-01 |
| Glycerophospholipid biosynthesis | 114 | 1.67e-01 | 0.074900 | 3.13e-01 |
| Mitochondrial biogenesis | 69 | 2.83e-01 | -0.074800 | 4.43e-01 |
| Signaling by Nuclear Receptors | 237 | 4.74e-02 | -0.074700 | 1.27e-01 |
| Peptide hormone biosynthesis | 11 | 6.68e-01 | 0.074700 | 7.94e-01 |
| Cell surface interactions at the vascular wall | 129 | 1.43e-01 | 0.074600 | 2.81e-01 |
| Signaling by ERBB2 KD Mutants | 24 | 5.28e-01 | -0.074500 | 6.77e-01 |
| GRB2 events in ERBB2 signaling | 16 | 6.06e-01 | 0.074500 | 7.52e-01 |
| Diseases of glycosylation | 137 | 1.33e-01 | 0.074300 | 2.67e-01 |
| Peptide hormone metabolism | 83 | 2.42e-01 | 0.074300 | 4.02e-01 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | 27 | 5.04e-01 | -0.074200 | 6.58e-01 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | 30 | 4.82e-01 | -0.074200 | 6.38e-01 |
| Downstream signaling of activated FGFR2 | 29 | 4.90e-01 | -0.074100 | 6.44e-01 |
| Transport of bile salts and organic acids, metal ions and amine compounds | 84 | 2.41e-01 | 0.074000 | 4.00e-01 |
| Signaling by ERBB2 TMD/JMD mutants | 21 | 5.58e-01 | -0.073800 | 7.08e-01 |
| NOTCH2 intracellular domain regulates transcription | 11 | 6.73e-01 | 0.073400 | 7.97e-01 |
| COPI-independent Golgi-to-ER retrograde traffic | 34 | 4.58e-01 | 0.073400 | 6.17e-01 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | 112 | 1.80e-01 | -0.073300 | 3.31e-01 |
| Opioid Signalling | 88 | 2.35e-01 | 0.073200 | 3.97e-01 |
| Branched-chain amino acid catabolism | 20 | 5.71e-01 | -0.073100 | 7.20e-01 |
| Phospholipase C-mediated cascade; FGFR3 | 12 | 6.63e-01 | -0.072700 | 7.91e-01 |
| Molecules associated with elastic fibres | 30 | 4.92e-01 | 0.072400 | 6.45e-01 |
| Post NMDA receptor activation events | 58 | 3.40e-01 | 0.072400 | 5.06e-01 |
| Golgi Associated Vesicle Biogenesis | 51 | 3.71e-01 | -0.072300 | 5.37e-01 |
| Hyaluronan uptake and degradation | 12 | 6.66e-01 | 0.071900 | 7.93e-01 |
| Downstream signaling of activated FGFR3 | 24 | 5.45e-01 | -0.071400 | 6.94e-01 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | 15 | 6.33e-01 | -0.071200 | 7.72e-01 |
| Transcriptional regulation of white adipocyte differentiation | 81 | 2.68e-01 | -0.071200 | 4.29e-01 |
| RHO GTPase Effectors | 232 | 6.24e-02 | -0.070900 | 1.57e-01 |
| Activation of NMDA receptors and postsynaptic events | 69 | 3.10e-01 | 0.070600 | 4.72e-01 |
| Signaling by NOTCH1 | 70 | 3.08e-01 | -0.070400 | 4.70e-01 |
| SUMOylation of DNA damage response and repair proteins | 71 | 3.06e-01 | -0.070300 | 4.68e-01 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 11 | 6.87e-01 | -0.070100 | 8.06e-01 |
| Cytokine Signaling in Immune system | 667 | 1.99e-03 | -0.070000 | 1.06e-02 |
| Interferon Signaling | 194 | 9.31e-02 | -0.069900 | 2.08e-01 |
| RHOBTB GTPase Cycle | 34 | 4.81e-01 | -0.069800 | 6.38e-01 |
| Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane | 10 | 7.04e-01 | 0.069500 | 8.13e-01 |
| Elevation of cytosolic Ca2+ levels | 16 | 6.32e-01 | 0.069100 | 7.72e-01 |
| Kinesins | 42 | 4.39e-01 | 0.069000 | 5.99e-01 |
| Signaling by PDGFRA extracellular domain mutants | 12 | 6.79e-01 | -0.068900 | 8.01e-01 |
| Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 12 | 6.79e-01 | -0.068900 | 8.01e-01 |
| Transcriptional activation of mitochondrial biogenesis | 51 | 3.94e-01 | -0.068900 | 5.58e-01 |
| SUMOylation of ubiquitinylation proteins | 37 | 4.68e-01 | -0.068900 | 6.25e-01 |
| RAB GEFs exchange GTP for GDP on RABs | 83 | 2.81e-01 | 0.068500 | 4.41e-01 |
| Striated Muscle Contraction | 33 | 4.96e-01 | 0.068400 | 6.50e-01 |
| Signaling by Erythropoietin | 25 | 5.58e-01 | -0.067700 | 7.08e-01 |
| CS/DS degradation | 12 | 6.86e-01 | -0.067500 | 8.05e-01 |
| Acyl chain remodelling of PG | 18 | 6.21e-01 | 0.067300 | 7.65e-01 |
| GPCR ligand binding | 444 | 1.49e-02 | 0.067300 | 5.36e-02 |
| Phase I - Functionalization of compounds | 100 | 2.47e-01 | 0.066900 | 4.07e-01 |
| FGFR1c ligand binding and activation | 11 | 7.02e-01 | -0.066700 | 8.13e-01 |
| Signaling by activated point mutants of FGFR1 | 11 | 7.02e-01 | -0.066700 | 8.13e-01 |
| Aquaporin-mediated transport | 51 | 4.12e-01 | 0.066300 | 5.76e-01 |
| Signaling by NOTCH3 | 48 | 4.28e-01 | -0.066200 | 5.92e-01 |
| Interleukin-35 Signalling | 12 | 6.95e-01 | -0.065400 | 8.11e-01 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | 17 | 6.40e-01 | 0.065400 | 7.74e-01 |
| Synthesis, secretion, and deacylation of Ghrelin | 19 | 6.23e-01 | -0.065100 | 7.65e-01 |
| Glycosphingolipid metabolism | 40 | 4.77e-01 | -0.064900 | 6.34e-01 |
| GPVI-mediated activation cascade | 32 | 5.25e-01 | 0.064800 | 6.76e-01 |
| Post-translational protein modification | 1294 | 8.31e-05 | -0.064800 | 6.55e-04 |
| Organic anion transporters | 10 | 7.25e-01 | -0.064300 | 8.27e-01 |
| Pre-NOTCH Transcription and Translation | 45 | 4.57e-01 | 0.064100 | 6.16e-01 |
| Organelle biogenesis and maintenance | 243 | 8.55e-02 | -0.064000 | 1.96e-01 |
| PI3K events in ERBB2 signaling | 16 | 6.60e-01 | 0.063500 | 7.91e-01 |
| PI-3K cascade:FGFR2 | 22 | 6.07e-01 | -0.063300 | 7.52e-01 |
| Anti-inflammatory response favouring Leishmania parasite infection | 164 | 1.62e-01 | 0.063200 | 3.06e-01 |
| Leishmania parasite growth and survival | 164 | 1.62e-01 | 0.063200 | 3.06e-01 |
| RHOD GTPase cycle | 49 | 4.48e-01 | 0.062700 | 6.07e-01 |
| RHO GTPases Activate NADPH Oxidases | 22 | 6.11e-01 | 0.062600 | 7.55e-01 |
| FGFR2 ligand binding and activation | 19 | 6.38e-01 | -0.062400 | 7.74e-01 |
| ADORA2B mediated anti-inflammatory cytokines production | 132 | 2.17e-01 | 0.062200 | 3.74e-01 |
| Downstream signal transduction | 29 | 5.64e-01 | -0.061900 | 7.11e-01 |
| MAPK family signaling cascades | 312 | 6.12e-02 | -0.061600 | 1.55e-01 |
| IRAK4 deficiency (TLR2/4) | 17 | 6.62e-01 | 0.061100 | 7.91e-01 |
| Leading Strand Synthesis | 13 | 7.03e-01 | -0.061100 | 8.13e-01 |
| Polymerase switching | 13 | 7.03e-01 | -0.061100 | 8.13e-01 |
| Signaling by Insulin receptor | 76 | 3.58e-01 | -0.060900 | 5.26e-01 |
| Class I MHC mediated antigen processing & presentation | 363 | 4.63e-02 | -0.060800 | 1.26e-01 |
| Interleukin-6 signaling | 11 | 7.28e-01 | -0.060600 | 8.30e-01 |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 11 | 7.29e-01 | 0.060400 | 8.30e-01 |
| Diseases of signal transduction by growth factor receptors and second messengers | 410 | 3.64e-02 | -0.060100 | 1.05e-01 |
| Fcgamma receptor (FCGR) dependent phagocytosis | 82 | 3.48e-01 | 0.059900 | 5.15e-01 |
| Activation of AMPK downstream of NMDARs | 10 | 7.43e-01 | -0.059800 | 8.42e-01 |
| Deadenylation of mRNA | 25 | 6.06e-01 | -0.059600 | 7.52e-01 |
| SHC-mediated cascade:FGFR4 | 19 | 6.53e-01 | -0.059600 | 7.87e-01 |
| MECP2 regulates neuronal receptors and channels | 17 | 6.71e-01 | 0.059400 | 7.96e-01 |
| Cellular hexose transport | 21 | 6.38e-01 | -0.059300 | 7.74e-01 |
| Cilium Assembly | 174 | 1.77e-01 | -0.059300 | 3.27e-01 |
| Neuronal System | 371 | 4.95e-02 | 0.059300 | 1.32e-01 |
| NCAM1 interactions | 36 | 5.38e-01 | 0.059300 | 6.87e-01 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 49 | 4.74e-01 | -0.059200 | 6.30e-01 |
| Macroautophagy | 111 | 2.86e-01 | -0.058600 | 4.48e-01 |
| Smooth Muscle Contraction | 39 | 5.27e-01 | 0.058500 | 6.77e-01 |
| Lagging Strand Synthesis | 19 | 6.60e-01 | -0.058400 | 7.91e-01 |
| Peroxisomal protein import | 62 | 4.28e-01 | -0.058200 | 5.92e-01 |
| Hyaluronan metabolism | 17 | 6.78e-01 | 0.058200 | 8.01e-01 |
| Amino acid transport across the plasma membrane | 30 | 5.82e-01 | 0.058000 | 7.30e-01 |
| CD28 dependent PI3K/Akt signaling | 22 | 6.37e-01 | 0.058000 | 7.74e-01 |
| tRNA Aminoacylation | 24 | 6.25e-01 | -0.057700 | 7.66e-01 |
| Metabolic disorders of biological oxidation enzymes | 32 | 5.73e-01 | 0.057600 | 7.21e-01 |
| Keratan sulfate biosynthesis | 28 | 5.98e-01 | 0.057500 | 7.47e-01 |
| Mitochondrial tRNA aminoacylation | 18 | 6.75e-01 | -0.057000 | 7.98e-01 |
| Extra-nuclear estrogen signaling | 73 | 4.00e-01 | -0.056900 | 5.64e-01 |
| Cytosolic sulfonation of small molecules | 23 | 6.36e-01 | 0.056900 | 7.74e-01 |
| Autophagy | 125 | 2.72e-01 | -0.056900 | 4.32e-01 |
| PI-3K cascade:FGFR3 | 17 | 6.87e-01 | -0.056300 | 8.06e-01 |
| Azathioprine ADME | 22 | 6.48e-01 | 0.056300 | 7.82e-01 |
| Regulation of TP53 Activity through Acetylation | 29 | 6.00e-01 | -0.056200 | 7.49e-01 |
| SHC1 events in EGFR signaling | 14 | 7.16e-01 | 0.056200 | 8.19e-01 |
| HDMs demethylate histones | 18 | 6.80e-01 | 0.056100 | 8.01e-01 |
| Adrenaline,noradrenaline inhibits insulin secretion | 28 | 6.07e-01 | -0.056100 | 7.52e-01 |
| Phase 4 - resting membrane potential | 19 | 6.72e-01 | -0.056100 | 7.97e-01 |
| WNT5A-dependent internalization of FZD4 | 15 | 7.07e-01 | -0.056000 | 8.14e-01 |
| Downstream signaling of activated FGFR4 | 26 | 6.22e-01 | -0.055900 | 7.65e-01 |
| MAPK1/MAPK3 signaling | 271 | 1.14e-01 | -0.055700 | 2.42e-01 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 12 | 7.39e-01 | -0.055500 | 8.39e-01 |
| alpha-linolenic acid (ALA) metabolism | 12 | 7.39e-01 | -0.055500 | 8.39e-01 |
| Factors involved in megakaryocyte development and platelet production | 130 | 2.76e-01 | 0.055200 | 4.37e-01 |
| IL-6-type cytokine receptor ligand interactions | 17 | 6.95e-01 | -0.055000 | 8.11e-01 |
| Transport of small molecules | 689 | 1.40e-02 | 0.054800 | 5.16e-02 |
| PD-1 signaling | 21 | 6.66e-01 | -0.054400 | 7.93e-01 |
| Activated NOTCH1 Transmits Signal to the Nucleus | 31 | 6.02e-01 | -0.054100 | 7.50e-01 |
| VEGFR2 mediated cell proliferation | 19 | 6.85e-01 | 0.053700 | 8.05e-01 |
| GABA receptor activation | 57 | 4.84e-01 | 0.053600 | 6.39e-01 |
| Biological oxidations | 216 | 1.74e-01 | 0.053600 | 3.23e-01 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | 51 | 5.12e-01 | -0.053000 | 6.65e-01 |
| IRF3-mediated induction of type I IFN | 11 | 7.63e-01 | -0.052600 | 8.56e-01 |
| Gap junction assembly | 18 | 7.01e-01 | 0.052300 | 8.13e-01 |
| Cytochrome P450 - arranged by substrate type | 64 | 4.70e-01 | 0.052200 | 6.26e-01 |
| Prostacyclin signalling through prostacyclin receptor | 19 | 6.94e-01 | -0.052200 | 8.11e-01 |
| Signal amplification | 33 | 6.05e-01 | -0.052100 | 7.52e-01 |
| Signaling by FGFR4 in disease | 11 | 7.66e-01 | -0.051700 | 8.59e-01 |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | 34 | 6.03e-01 | -0.051500 | 7.51e-01 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 25 | 6.56e-01 | 0.051500 | 7.88e-01 |
| Signaling by Non-Receptor Tyrosine Kinases | 55 | 5.09e-01 | -0.051500 | 6.62e-01 |
| Signaling by PTK6 | 55 | 5.09e-01 | -0.051500 | 6.62e-01 |
| N-Glycan antennae elongation | 15 | 7.32e-01 | 0.051100 | 8.33e-01 |
| RAF/MAP kinase cascade | 265 | 1.53e-01 | -0.050900 | 2.92e-01 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | 54 | 5.22e-01 | -0.050400 | 6.73e-01 |
| Disorders of transmembrane transporters | 167 | 2.61e-01 | -0.050400 | 4.23e-01 |
| Activation of G protein gated Potassium channels | 29 | 6.40e-01 | -0.050100 | 7.74e-01 |
| G protein gated Potassium channels | 29 | 6.40e-01 | -0.050100 | 7.74e-01 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 29 | 6.40e-01 | -0.050100 | 7.74e-01 |
| Nuclear signaling by ERBB4 | 32 | 6.25e-01 | 0.050000 | 7.66e-01 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 20 | 7.00e-01 | -0.049800 | 8.13e-01 |
| Serotonin Neurotransmitter Release Cycle | 16 | 7.32e-01 | 0.049400 | 8.33e-01 |
| LDL clearance | 19 | 7.10e-01 | -0.049300 | 8.16e-01 |
| Gap junction trafficking | 27 | 6.57e-01 | 0.049300 | 7.89e-01 |
| Signaling by FGFR3 in disease | 21 | 6.96e-01 | -0.049200 | 8.11e-01 |
| SHC1 events in ERBB4 signaling | 14 | 7.50e-01 | -0.049100 | 8.47e-01 |
| TNFR1-induced NFkappaB signaling pathway | 22 | 6.94e-01 | -0.048400 | 8.11e-01 |
| Chylomicron remodeling | 10 | 7.91e-01 | 0.048300 | 8.76e-01 |
| RA biosynthesis pathway | 22 | 6.95e-01 | -0.048300 | 8.11e-01 |
| CD28 co-stimulation | 32 | 6.39e-01 | 0.047900 | 7.74e-01 |
| SLC transporter disorders | 92 | 4.28e-01 | 0.047800 | 5.92e-01 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 12 | 7.75e-01 | 0.047700 | 8.65e-01 |
| Intracellular signaling by second messengers | 313 | 1.48e-01 | -0.047500 | 2.87e-01 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 29 | 6.61e-01 | -0.047000 | 7.91e-01 |
| Chromatin modifying enzymes | 185 | 2.73e-01 | -0.046700 | 4.32e-01 |
| Chromatin organization | 185 | 2.73e-01 | -0.046700 | 4.32e-01 |
| Negative regulation of the PI3K/AKT network | 111 | 3.96e-01 | 0.046600 | 5.59e-01 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 16 | 7.47e-01 | -0.046500 | 8.45e-01 |
| Circadian Clock | 69 | 5.05e-01 | -0.046400 | 6.58e-01 |
| Signaling by SCF-KIT | 43 | 6.04e-01 | 0.045700 | 7.52e-01 |
| Constitutive Signaling by Aberrant PI3K in Cancer | 77 | 4.90e-01 | 0.045500 | 6.44e-01 |
| Interferon gamma signaling | 90 | 4.62e-01 | 0.044800 | 6.18e-01 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | 38 | 6.34e-01 | -0.044600 | 7.72e-01 |
| Activated point mutants of FGFR2 | 16 | 7.58e-01 | -0.044400 | 8.52e-01 |
| Golgi-to-ER retrograde transport | 115 | 4.11e-01 | -0.044400 | 5.75e-01 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 42 | 6.20e-01 | 0.044200 | 7.65e-01 |
| Beta-oxidation of very long chain fatty acids | 10 | 8.10e-01 | 0.044000 | 8.90e-01 |
| Neutrophil degranulation | 458 | 1.06e-01 | -0.044000 | 2.28e-01 |
| Vasopressin regulates renal water homeostasis via Aquaporins | 42 | 6.22e-01 | 0.044000 | 7.65e-01 |
| Regulation of signaling by NODAL | 11 | 8.01e-01 | -0.043800 | 8.83e-01 |
| Carboxyterminal post-translational modifications of tubulin | 40 | 6.32e-01 | 0.043800 | 7.72e-01 |
| Cell-extracellular matrix interactions | 14 | 7.77e-01 | 0.043800 | 8.66e-01 |
| Phospholipase C-mediated cascade; FGFR4 | 14 | 7.77e-01 | -0.043700 | 8.66e-01 |
| Glutamate Neurotransmitter Release Cycle | 23 | 7.18e-01 | -0.043600 | 8.21e-01 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | 181 | 3.13e-01 | -0.043400 | 4.76e-01 |
| Assembly and cell surface presentation of NMDA receptors | 23 | 7.20e-01 | 0.043200 | 8.23e-01 |
| Transmission across Chemical Synapses | 237 | 2.57e-01 | 0.042700 | 4.17e-01 |
| Erythrocytes take up carbon dioxide and release oxygen | 12 | 7.98e-01 | -0.042700 | 8.81e-01 |
| O2/CO2 exchange in erythrocytes | 12 | 7.98e-01 | -0.042700 | 8.81e-01 |
| Signaling by NTRK2 (TRKB) | 25 | 7.12e-01 | -0.042700 | 8.17e-01 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | 12 | 7.98e-01 | 0.042600 | 8.81e-01 |
| Sema4D induced cell migration and growth-cone collapse | 20 | 7.45e-01 | -0.042100 | 8.43e-01 |
| Metabolism of carbohydrates | 275 | 2.40e-01 | -0.041100 | 4.00e-01 |
| Nucleotide catabolism | 35 | 6.74e-01 | -0.041000 | 7.98e-01 |
| RHOBTB2 GTPase cycle | 22 | 7.40e-01 | -0.040800 | 8.40e-01 |
| Metabolism | 1967 | 2.69e-03 | -0.040600 | 1.33e-02 |
| Signaling by ERBB2 | 49 | 6.25e-01 | -0.040400 | 7.66e-01 |
| Nuclear Envelope Breakdown | 50 | 6.28e-01 | -0.039600 | 7.69e-01 |
| Uptake and actions of bacterial toxins | 29 | 7.14e-01 | -0.039300 | 8.19e-01 |
| PI3K events in ERBB4 signaling | 10 | 8.30e-01 | -0.039200 | 9.04e-01 |
| DAP12 interactions | 40 | 6.68e-01 | -0.039200 | 7.94e-01 |
| Transport of vitamins, nucleosides, and related molecules | 38 | 6.76e-01 | 0.039200 | 7.98e-01 |
| Miscellaneous transport and binding events | 21 | 7.58e-01 | 0.038900 | 8.52e-01 |
| Gene Silencing by RNA | 80 | 5.54e-01 | -0.038300 | 7.04e-01 |
| Acyl chain remodelling of PE | 24 | 7.46e-01 | 0.038200 | 8.44e-01 |
| Signaling by FGFR1 in disease | 37 | 6.88e-01 | 0.038200 | 8.06e-01 |
| Listeria monocytogenes entry into host cells | 19 | 7.76e-01 | 0.037600 | 8.66e-01 |
| Sphingolipid metabolism | 81 | 5.59e-01 | 0.037600 | 7.08e-01 |
| Defective B3GAT3 causes JDSSDHD | 17 | 7.90e-01 | 0.037300 | 8.76e-01 |
| Regulation of TP53 Activity through Association with Co-factors | 14 | 8.10e-01 | -0.037100 | 8.90e-01 |
| ATF6 (ATF6-alpha) activates chaperone genes | 10 | 8.40e-01 | -0.036800 | 9.10e-01 |
| PI-3K cascade:FGFR4 | 19 | 7.82e-01 | -0.036700 | 8.69e-01 |
| Signaling by Rho GTPases | 590 | 1.28e-01 | 0.036600 | 2.60e-01 |
| Leishmania infection | 245 | 3.28e-01 | 0.036300 | 4.91e-01 |
| FRS-mediated FGFR2 signaling | 24 | 7.60e-01 | -0.036000 | 8.53e-01 |
| Receptor Mediated Mitophagy | 10 | 8.45e-01 | -0.035700 | 9.13e-01 |
| Interleukin-37 signaling | 21 | 7.77e-01 | 0.035600 | 8.66e-01 |
| Amyloid fiber formation | 53 | 6.54e-01 | -0.035600 | 7.87e-01 |
| Miscellaneous substrates | 12 | 8.33e-01 | 0.035200 | 9.04e-01 |
| Heparan sulfate/heparin (HS-GAG) metabolism | 49 | 6.71e-01 | 0.035100 | 7.96e-01 |
| Signaling by Receptor Tyrosine Kinases | 492 | 1.84e-01 | -0.034900 | 3.37e-01 |
| RHO GTPases Activate ROCKs | 19 | 7.94e-01 | -0.034600 | 8.78e-01 |
| Activation of gene expression by SREBF (SREBP) | 42 | 7.01e-01 | -0.034200 | 8.13e-01 |
| SUMOylation of intracellular receptors | 29 | 7.50e-01 | 0.034200 | 8.47e-01 |
| ERBB2 Regulates Cell Motility | 15 | 8.21e-01 | 0.033700 | 8.99e-01 |
| Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 604 | 1.64e-01 | 0.033000 | 3.09e-01 |
| Diseases of carbohydrate metabolism | 30 | 7.55e-01 | -0.033000 | 8.50e-01 |
| Interleukin-15 signaling | 13 | 8.37e-01 | -0.033000 | 9.08e-01 |
| Diseases of metabolism | 234 | 3.89e-01 | 0.032600 | 5.54e-01 |
| Pre-NOTCH Expression and Processing | 61 | 6.63e-01 | 0.032300 | 7.91e-01 |
| Chondroitin sulfate/dermatan sulfate metabolism | 45 | 7.10e-01 | -0.032000 | 8.16e-01 |
| IRS-related events triggered by IGF1R | 50 | 6.97e-01 | 0.031900 | 8.11e-01 |
| EPH-ephrin mediated repulsion of cells | 48 | 7.03e-01 | -0.031800 | 8.13e-01 |
| DARPP-32 events | 24 | 7.90e-01 | -0.031300 | 8.76e-01 |
| EPHB-mediated forward signaling | 34 | 7.56e-01 | 0.030700 | 8.51e-01 |
| Vitamin D (calciferol) metabolism | 12 | 8.54e-01 | -0.030700 | 9.20e-01 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | 21 | 8.08e-01 | -0.030700 | 8.89e-01 |
| Detoxification of Reactive Oxygen Species | 35 | 7.57e-01 | -0.030200 | 8.51e-01 |
| Tight junction interactions | 28 | 7.82e-01 | 0.030100 | 8.69e-01 |
| Thrombin signalling through proteinase activated receptors (PARs) | 32 | 7.68e-01 | -0.030100 | 8.60e-01 |
| Inflammasomes | 21 | 8.12e-01 | 0.030000 | 8.91e-01 |
| PI3K/AKT Signaling in Cancer | 103 | 5.99e-01 | 0.030000 | 7.48e-01 |
| Retrograde transport at the Trans-Golgi-Network | 47 | 7.22e-01 | -0.029900 | 8.25e-01 |
| Rap1 signalling | 16 | 8.39e-01 | -0.029400 | 9.09e-01 |
| Meiosis | 56 | 7.04e-01 | -0.029400 | 8.13e-01 |
| Frs2-mediated activation | 12 | 8.60e-01 | 0.029300 | 9.23e-01 |
| FOXO-mediated transcription | 65 | 6.84e-01 | -0.029200 | 8.04e-01 |
| Serotonin receptors | 11 | 8.67e-01 | 0.029200 | 9.26e-01 |
| RND3 GTPase cycle | 41 | 7.48e-01 | 0.029000 | 8.45e-01 |
| FCGR3A-mediated phagocytosis | 57 | 7.07e-01 | 0.028800 | 8.14e-01 |
| Leishmania phagocytosis | 57 | 7.07e-01 | 0.028800 | 8.14e-01 |
| Parasite infection | 57 | 7.07e-01 | 0.028800 | 8.14e-01 |
| Glyoxylate metabolism and glycine degradation | 30 | 7.85e-01 | -0.028700 | 8.72e-01 |
| FGFR3 ligand binding and activation | 12 | 8.66e-01 | -0.028200 | 9.26e-01 |
| FGFR3c ligand binding and activation | 12 | 8.66e-01 | -0.028200 | 9.26e-01 |
| NOTCH3 Intracellular Domain Regulates Transcription | 24 | 8.12e-01 | 0.028000 | 8.91e-01 |
| Regulation of actin dynamics for phagocytic cup formation | 59 | 7.16e-01 | -0.027400 | 8.19e-01 |
| The NLRP3 inflammasome | 16 | 8.51e-01 | -0.027200 | 9.17e-01 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 52 | 7.35e-01 | 0.027100 | 8.36e-01 |
| Signaling by MET | 66 | 7.05e-01 | 0.026900 | 8.14e-01 |
| Glycosaminoglycan metabolism | 116 | 6.23e-01 | 0.026400 | 7.65e-01 |
| Depolymerisation of the Nuclear Lamina | 14 | 8.64e-01 | 0.026400 | 9.25e-01 |
| RHOF GTPase cycle | 40 | 7.74e-01 | 0.026200 | 8.65e-01 |
| Apoptotic execution phase | 43 | 7.67e-01 | 0.026100 | 8.59e-01 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 24 | 8.27e-01 | -0.025800 | 9.03e-01 |
| GPER1 signaling | 44 | 7.69e-01 | 0.025500 | 8.61e-01 |
| Membrane Trafficking | 586 | 2.91e-01 | -0.025500 | 4.53e-01 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 23 | 8.33e-01 | -0.025400 | 9.04e-01 |
| Ras activation upon Ca2+ influx through NMDA receptor | 19 | 8.49e-01 | 0.025200 | 9.17e-01 |
| FGFR3 mutant receptor activation | 11 | 8.85e-01 | -0.025200 | 9.33e-01 |
| Signaling by activated point mutants of FGFR3 | 11 | 8.85e-01 | -0.025200 | 9.33e-01 |
| FGFR1 mutant receptor activation | 30 | 8.18e-01 | 0.024300 | 8.96e-01 |
| Synaptic adhesion-like molecules | 19 | 8.56e-01 | 0.024100 | 9.21e-01 |
| InlB-mediated entry of Listeria monocytogenes into host cell | 14 | 8.77e-01 | -0.024000 | 9.31e-01 |
| APC truncation mutants have impaired AXIN binding | 13 | 8.83e-01 | -0.023600 | 9.32e-01 |
| AXIN missense mutants destabilize the destruction complex | 13 | 8.83e-01 | -0.023600 | 9.32e-01 |
| Signaling by AMER1 mutants | 13 | 8.83e-01 | -0.023600 | 9.32e-01 |
| Signaling by APC mutants | 13 | 8.83e-01 | -0.023600 | 9.32e-01 |
| Signaling by AXIN mutants | 13 | 8.83e-01 | -0.023600 | 9.32e-01 |
| Truncations of AMER1 destabilize the destruction complex | 13 | 8.83e-01 | -0.023600 | 9.32e-01 |
| DAP12 signaling | 28 | 8.30e-01 | -0.023400 | 9.04e-01 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 13 | 8.85e-01 | -0.023100 | 9.33e-01 |
| Signaling by WNT in cancer | 32 | 8.22e-01 | 0.022900 | 9.00e-01 |
| TNFs bind their physiological receptors | 25 | 8.44e-01 | -0.022700 | 9.13e-01 |
| FRS-mediated FGFR3 signaling | 19 | 8.64e-01 | -0.022700 | 9.25e-01 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 104 | 6.93e-01 | 0.022400 | 8.11e-01 |
| IGF1R signaling cascade | 51 | 7.82e-01 | 0.022400 | 8.69e-01 |
| GAB1 signalosome | 17 | 8.73e-01 | 0.022300 | 9.29e-01 |
| A tetrasaccharide linker sequence is required for GAG synthesis | 23 | 8.57e-01 | 0.021700 | 9.21e-01 |
| STING mediated induction of host immune responses | 13 | 8.92e-01 | -0.021700 | 9.33e-01 |
| Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 16 | 8.81e-01 | -0.021600 | 9.32e-01 |
| Plasma lipoprotein assembly, remodeling, and clearance | 73 | 7.51e-01 | -0.021400 | 8.47e-01 |
| CD28 dependent Vav1 pathway | 11 | 9.02e-01 | 0.021400 | 9.38e-01 |
| MHC class II antigen presentation | 104 | 7.15e-01 | 0.020700 | 8.19e-01 |
| Metalloprotease DUBs | 19 | 8.76e-01 | -0.020600 | 9.31e-01 |
| CTNNB1 S33 mutants aren’t phosphorylated | 14 | 8.94e-01 | -0.020500 | 9.33e-01 |
| CTNNB1 S37 mutants aren’t phosphorylated | 14 | 8.94e-01 | -0.020500 | 9.33e-01 |
| CTNNB1 S45 mutants aren’t phosphorylated | 14 | 8.94e-01 | -0.020500 | 9.33e-01 |
| CTNNB1 T41 mutants aren’t phosphorylated | 14 | 8.94e-01 | -0.020500 | 9.33e-01 |
| Signaling by CTNNB1 phospho-site mutants | 14 | 8.94e-01 | -0.020500 | 9.33e-01 |
| Signaling by GSK3beta mutants | 14 | 8.94e-01 | -0.020500 | 9.33e-01 |
| ADP signalling through P2Y purinoceptor 1 | 25 | 8.59e-01 | -0.020500 | 9.22e-01 |
| G beta:gamma signalling through PI3Kgamma | 25 | 8.67e-01 | -0.019400 | 9.26e-01 |
| PI3K Cascade | 43 | 8.27e-01 | 0.019300 | 9.03e-01 |
| Activation of GABAB receptors | 43 | 8.29e-01 | 0.019000 | 9.04e-01 |
| GABA B receptor activation | 43 | 8.29e-01 | 0.019000 | 9.04e-01 |
| Pregnenolone biosynthesis | 10 | 9.17e-01 | -0.019000 | 9.47e-01 |
| Elastic fibre formation | 41 | 8.35e-01 | 0.018800 | 9.07e-01 |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 12 | 9.11e-01 | -0.018700 | 9.42e-01 |
| Keratan sulfate/keratin metabolism | 33 | 8.55e-01 | 0.018400 | 9.20e-01 |
| Signaling by ERBB4 | 57 | 8.11e-01 | -0.018300 | 8.90e-01 |
| Dopamine Neurotransmitter Release Cycle | 20 | 8.89e-01 | 0.018000 | 9.33e-01 |
| Sialic acid metabolism | 33 | 8.59e-01 | 0.017900 | 9.22e-01 |
| Activation of BAD and translocation to mitochondria | 15 | 9.05e-01 | -0.017800 | 9.39e-01 |
| Signaling by KIT in disease | 20 | 8.90e-01 | 0.017800 | 9.33e-01 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | 20 | 8.90e-01 | 0.017800 | 9.33e-01 |
| Activation of kainate receptors upon glutamate binding | 29 | 8.71e-01 | -0.017400 | 9.27e-01 |
| Nuclear Receptor transcription pathway | 51 | 8.32e-01 | -0.017200 | 9.04e-01 |
| Fatty acid metabolism | 167 | 7.02e-01 | 0.017200 | 8.13e-01 |
| Innate Immune System | 999 | 3.60e-01 | -0.017100 | 5.28e-01 |
| Syndecan interactions | 19 | 8.98e-01 | 0.017000 | 9.36e-01 |
| IRS-mediated signalling | 47 | 8.43e-01 | 0.016700 | 9.12e-01 |
| Adaptive Immune System | 711 | 4.49e-01 | -0.016600 | 6.08e-01 |
| Glucagon-type ligand receptors | 33 | 8.71e-01 | 0.016400 | 9.27e-01 |
| EPH-Ephrin signaling | 90 | 7.93e-01 | -0.016000 | 8.78e-01 |
| Transcriptional Regulation by MECP2 | 60 | 8.31e-01 | -0.015900 | 9.04e-01 |
| Pre-NOTCH Processing in Golgi | 18 | 9.09e-01 | -0.015500 | 9.42e-01 |
| G-protein activation | 24 | 8.95e-01 | -0.015500 | 9.34e-01 |
| Sema4D in semaphorin signaling | 24 | 8.98e-01 | -0.015100 | 9.36e-01 |
| Amine ligand-binding receptors | 41 | 8.68e-01 | -0.015000 | 9.26e-01 |
| G alpha (z) signalling events | 48 | 8.57e-01 | 0.015000 | 9.21e-01 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 12 | 9.28e-01 | 0.015000 | 9.54e-01 |
| NOTCH4 Intracellular Domain Regulates Transcription | 19 | 9.10e-01 | 0.014900 | 9.42e-01 |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | 20 | 9.09e-01 | -0.014800 | 9.42e-01 |
| Intra-Golgi traffic | 43 | 8.70e-01 | 0.014400 | 9.27e-01 |
| Defective B4GALT7 causes EDS, progeroid type | 17 | 9.21e-01 | 0.014000 | 9.50e-01 |
| Mitochondrial Fatty Acid Beta-Oxidation | 35 | 8.87e-01 | -0.013900 | 9.33e-01 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | 26 | 9.02e-01 | -0.013900 | 9.38e-01 |
| HuR (ELAVL1) binds and stabilizes mRNA | 10 | 9.41e-01 | 0.013600 | 9.64e-01 |
| Metabolism of water-soluble vitamins and cofactors | 118 | 8.03e-01 | -0.013300 | 8.84e-01 |
| Late endosomal microautophagy | 32 | 9.01e-01 | -0.012700 | 9.38e-01 |
| Signaling by EGFR | 49 | 8.79e-01 | 0.012500 | 9.32e-01 |
| Meiotic synapsis | 32 | 9.04e-01 | 0.012400 | 9.39e-01 |
| Signal regulatory protein family interactions | 13 | 9.39e-01 | 0.012200 | 9.64e-01 |
| FGFR2c ligand binding and activation | 12 | 9.42e-01 | -0.012200 | 9.64e-01 |
| Ca2+ pathway | 62 | 8.71e-01 | -0.011900 | 9.27e-01 |
| Diseases associated with the TLR signaling cascade | 29 | 9.18e-01 | -0.011100 | 9.47e-01 |
| Diseases of Immune System | 29 | 9.18e-01 | -0.011100 | 9.47e-01 |
| Arachidonic acid metabolism | 56 | 8.92e-01 | -0.010400 | 9.33e-01 |
| Assembly of active LPL and LIPC lipase complexes | 17 | 9.42e-01 | 0.010100 | 9.64e-01 |
| EGFR downregulation | 30 | 9.24e-01 | 0.010100 | 9.52e-01 |
| Surfactant metabolism | 29 | 9.26e-01 | -0.010000 | 9.53e-01 |
| Developmental Biology | 1020 | 5.92e-01 | -0.009880 | 7.40e-01 |
| Death Receptor Signalling | 129 | 8.49e-01 | -0.009680 | 9.17e-01 |
| Generation of second messenger molecules | 30 | 9.28e-01 | 0.009550 | 9.54e-01 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | 15 | 9.51e-01 | 0.009190 | 9.70e-01 |
| Cell recruitment (pro-inflammatory response) | 25 | 9.44e-01 | 0.008130 | 9.65e-01 |
| Purinergic signaling in leishmaniasis infection | 25 | 9.44e-01 | 0.008130 | 9.65e-01 |
| FRS-mediated FGFR4 signaling | 21 | 9.49e-01 | -0.008100 | 9.69e-01 |
| PIWI-interacting RNA (piRNA) biogenesis | 29 | 9.42e-01 | -0.007820 | 9.64e-01 |
| Voltage gated Potassium channels | 42 | 9.32e-01 | 0.007590 | 9.57e-01 |
| Rab regulation of trafficking | 114 | 8.90e-01 | 0.007460 | 9.33e-01 |
| Insulin receptor signalling cascade | 53 | 9.26e-01 | 0.007410 | 9.53e-01 |
| Norepinephrine Neurotransmitter Release Cycle | 16 | 9.62e-01 | -0.006880 | 9.78e-01 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | 12 | 9.68e-01 | -0.006700 | 9.82e-01 |
| Signaling by FLT3 fusion proteins | 19 | 9.61e-01 | -0.006520 | 9.77e-01 |
| Vesicle-mediated transport | 624 | 7.83e-01 | -0.006430 | 8.70e-01 |
| Platelet sensitization by LDL | 17 | 9.64e-01 | -0.006370 | 9.79e-01 |
| Metabolism of vitamins and cofactors | 181 | 8.86e-01 | 0.006190 | 9.33e-01 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 120 | 9.10e-01 | -0.005970 | 9.42e-01 |
| MET activates RAS signaling | 11 | 9.74e-01 | -0.005710 | 9.85e-01 |
| HDL remodeling | 10 | 9.76e-01 | -0.005560 | 9.85e-01 |
| Post-translational modification: synthesis of GPI-anchored proteins | 90 | 9.28e-01 | 0.005490 | 9.54e-01 |
| Peroxisomal lipid metabolism | 28 | 9.60e-01 | 0.005460 | 9.77e-01 |
| Signal Transduction | 2408 | 6.63e-01 | 0.005380 | 7.91e-01 |
| Retrograde neurotrophin signalling | 14 | 9.74e-01 | 0.005060 | 9.85e-01 |
| Phosphorylation of CD3 and TCR zeta chains | 20 | 9.71e-01 | 0.004730 | 9.83e-01 |
| Costimulation by the CD28 family | 65 | 9.50e-01 | 0.004540 | 9.69e-01 |
| Heme biosynthesis | 13 | 9.78e-01 | -0.004480 | 9.85e-01 |
| Signaling by ALK fusions and activated point mutants | 51 | 9.58e-01 | -0.004220 | 9.76e-01 |
| Signaling by ALK in cancer | 51 | 9.58e-01 | -0.004220 | 9.76e-01 |
| Inwardly rectifying K+ channels | 35 | 9.66e-01 | -0.004200 | 9.80e-01 |
| FCERI mediated MAPK activation | 29 | 9.69e-01 | -0.004190 | 9.82e-01 |
| G-protein beta:gamma signalling | 30 | 9.69e-01 | -0.004140 | 9.82e-01 |
| Signaling by PDGFR in disease | 20 | 9.75e-01 | 0.004060 | 9.85e-01 |
| Chondroitin sulfate biosynthesis | 18 | 9.77e-01 | -0.003960 | 9.85e-01 |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | 11 | 9.82e-01 | -0.003910 | 9.89e-01 |
| Immune System | 1877 | 8.12e-01 | -0.003280 | 8.91e-01 |
| Vitamin B5 (pantothenate) metabolism | 16 | 9.84e-01 | 0.002930 | 9.90e-01 |
| Translocation of ZAP-70 to Immunological synapse | 17 | 9.86e-01 | 0.002390 | 9.90e-01 |
| Intraflagellar transport | 36 | 9.80e-01 | -0.002370 | 9.88e-01 |
| ATF6 (ATF6-alpha) activates chaperones | 11 | 9.91e-01 | 0.002060 | 9.93e-01 |
| The role of Nef in HIV-1 replication and disease pathogenesis | 27 | 9.86e-01 | 0.001980 | 9.90e-01 |
| Regulation of MECP2 expression and activity | 30 | 9.86e-01 | 0.001830 | 9.90e-01 |
| Potassium Channels | 102 | 9.75e-01 | -0.001800 | 9.85e-01 |
| HS-GAG degradation | 18 | 9.91e-01 | -0.001600 | 9.93e-01 |
| FGFR4 ligand binding and activation | 13 | 9.94e-01 | -0.001290 | 9.96e-01 |
| Constitutive Signaling by AKT1 E17K in Cancer | 25 | 9.95e-01 | 0.000655 | 9.97e-01 |
| Synthesis of PC | 27 | 9.97e-01 | 0.000379 | 9.98e-01 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | 37 | 9.98e-01 | -0.000270 | 9.98e-01 |
Detailed Gene set reports
Digestion of dietary carbohydrate
| 318 | |
|---|---|
| set | Digestion of dietary carbohydrate |
| setSize | 10 |
| pANOVA | 0.000677 |
| s.dist | 0.621 |
| p.adjustANOVA | 0.00402 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MGAM | 15264 |
| LCT | 14248 |
| AMY2B | 14112 |
| CHIA | 13855 |
| AMY2A | 12239 |
| CHIT1 | 9664 |
| AMY1B | 8406 |
| AMY1C | 8406 |
| AMY1A | 8406 |
| TREH | 3800 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MGAM | 15264 |
| LCT | 14248 |
| AMY2B | 14112 |
| CHIA | 13855 |
| AMY2A | 12239 |
| CHIT1 | 9664 |
| AMY1B | 8406 |
| AMY1C | 8406 |
| AMY1A | 8406 |
| TREH | 3800 |
Eukaryotic Translation Elongation
| 395 | |
|---|---|
| set | Eukaryotic Translation Elongation |
| setSize | 88 |
| pANOVA | 8.18e-24 |
| s.dist | -0.62 |
| p.adjustANOVA | 9.61e-22 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| EEF1B2 | -9306 |
| RPL19 | -9282 |
| RPL36 | -9233 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| EEF1B2 | -9306.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| EEF1A2 | -7693.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| EEF1G | -6379.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| EEF1A1 | -4747.0 |
| RPS20 | -4527.0 |
| EEF1D | -4491.0 |
| RPL21 | -4286.5 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| EEF2 | -2449.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| RPL3 | 5754.0 |
| RPL10L | 6857.0 |
| RPL5 | 9083.0 |
| RPL3L | 12071.0 |
Peptide chain elongation
| 896 | |
|---|---|
| set | Peptide chain elongation |
| setSize | 84 |
| pANOVA | 2.15e-22 |
| s.dist | -0.614 |
| p.adjustANOVA | 2.19e-20 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| RPL36 | -9233 |
| RPL7 | -9178 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| EEF1A1 | -4747.0 |
| RPS20 | -4527.0 |
| RPL21 | -4286.5 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| EEF2 | -2449.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| RPL3 | 5754.0 |
| RPL10L | 6857.0 |
| RPL5 | 9083.0 |
| RPL3L | 12071.0 |
Viral mRNA Translation
| 1478 | |
|---|---|
| set | Viral mRNA Translation |
| setSize | 84 |
| pANOVA | 2.62e-22 |
| s.dist | -0.612 |
| p.adjustANOVA | 2.5e-20 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| RPL36 | -9233 |
| RPL7 | -9178 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| GRSF1 | -7458.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| RPS20 | -4527.0 |
| RPL21 | -4286.5 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| DNAJC3 | 1650.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| RPL3 | 5754.0 |
| RPL10L | 6857.0 |
| RPL5 | 9083.0 |
| RPL3L | 12071.0 |
SUMOylation of immune response proteins
| 1183 | |
|---|---|
| set | SUMOylation of immune response proteins |
| setSize | 10 |
| pANOVA | 0.000877 |
| s.dist | -0.607 |
| p.adjustANOVA | 0.00502 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| NFKBIA | -10283 |
| PIAS3 | -9807 |
| NFKB2 | -9539 |
| TOPORS | -8604 |
| RELA | -7417 |
| IKBKE | -5556 |
| UBE2I | -4222 |
| SUMO1 | -2701 |
| PIAS4 | -1329 |
| SUMO3 | 7379 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| NFKBIA | -10283 |
| PIAS3 | -9807 |
| NFKB2 | -9539 |
| TOPORS | -8604 |
| RELA | -7417 |
| IKBKE | -5556 |
| UBE2I | -4222 |
| SUMO1 | -2701 |
| PIAS4 | -1329 |
| SUMO3 | 7379 |
Eukaryotic Translation Termination
| 397 | |
|---|---|
| set | Eukaryotic Translation Termination |
| setSize | 87 |
| pANOVA | 9.34e-22 |
| s.dist | -0.594 |
| p.adjustANOVA | 7.93e-20 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| TRMT112 | -10337 |
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| RPL36 | -9233 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| TRMT112 | -10337.0 |
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| APEH | -6121.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| RPS20 | -4527.0 |
| RPL21 | -4286.5 |
| N6AMT1 | -4181.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| ETF1 | 5376.0 |
| RPL3 | 5754.0 |
| RPL10L | 6857.0 |
| RPL5 | 9083.0 |
| RPL3L | 12071.0 |
| GSPT1 | 14967.0 |
Interaction With Cumulus Cells And The Zona Pellucida
| 611 | |
|---|---|
| set | Interaction With Cumulus Cells And The Zona Pellucida |
| setSize | 11 |
| pANOVA | 0.000664 |
| s.dist | 0.593 |
| p.adjustANOVA | 0.00396 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| SPAM1 | 15261.0 |
| ZP3 | 14856.0 |
| ADAM2 | 14678.0 |
| ZP2 | 13562.0 |
| ZP4 | 13504.0 |
| ADAM30 | 13154.0 |
| OVGP1 | 12945.0 |
| ADAM20 | 11076.0 |
| ADAM21 | 9754.0 |
| ZP1 | 0.5 |
| B4GALT1 | -3574.0 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| SPAM1 | 15261.0 |
| ZP3 | 14856.0 |
| ADAM2 | 14678.0 |
| ZP2 | 13562.0 |
| ZP4 | 13504.0 |
| ADAM30 | 13154.0 |
| OVGP1 | 12945.0 |
| ADAM20 | 11076.0 |
| ADAM21 | 9754.0 |
| ZP1 | 0.5 |
| B4GALT1 | -3574.0 |
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
| 1364 | |
|---|---|
| set | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| setSize | 14 |
| pANOVA | 0.000136 |
| s.dist | -0.589 |
| p.adjustANOVA | 0.00101 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| CDKN1B | -10339.0 |
| TP53 | -9937.0 |
| CCNA1 | -9890.0 |
| CCNA2 | -9341.0 |
| CCNE2 | -7017.0 |
| CCNE1 | -6025.0 |
| E2F8 | -5894.0 |
| E2F1 | -4198.0 |
| ZNF385A | -4127.0 |
| CDK2 | -3347.0 |
| PCBP4 | -1214.0 |
| E2F7 | 0.5 |
| CDKN1A | 0.5 |
| ARID3A | 1848.0 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| CDKN1B | -10339.0 |
| TP53 | -9937.0 |
| CCNA1 | -9890.0 |
| CCNA2 | -9341.0 |
| CCNE2 | -7017.0 |
| CCNE1 | -6025.0 |
| E2F8 | -5894.0 |
| E2F1 | -4198.0 |
| ZNF385A | -4127.0 |
| CDK2 | -3347.0 |
| PCBP4 | -1214.0 |
| E2F7 | 0.5 |
| CDKN1A | 0.5 |
| ARID3A | 1848.0 |
Selenocysteine synthesis
| 1193 | |
|---|---|
| set | Selenocysteine synthesis |
| setSize | 87 |
| pANOVA | 1.12e-20 |
| s.dist | -0.578 |
| p.adjustANOVA | 6.86e-19 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| RPL36 | -9233 |
| RPL7 | -9178 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| RPS20 | -4527.0 |
| SEPSECS | -4437.0 |
| RPL21 | -4286.5 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| SEPHS2 | 0.5 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| SECISBP2 | 2881.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| PSTK | 5284.0 |
| RPL3 | 5754.0 |
| RPL10L | 6857.0 |
| RPL5 | 9083.0 |
| RPL3L | 12071.0 |
| EEFSEC | 14214.0 |
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
| 1333 | |
|---|---|
| set | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| setSize | 15 |
| pANOVA | 0.000108 |
| s.dist | 0.577 |
| p.adjustANOVA | 0.000821 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| NCOA1 | 15583 |
| AKR1C2 | 15531 |
| AKR1C3 | 15390 |
| AKR1D1 | 15342 |
| NCOA2 | 15265 |
| AKR1C4 | 14564 |
| AKR1C1 | 14333 |
| NR1H4 | 12633 |
| CYP7A1 | 12478 |
| CYP8B1 | 10099 |
| CYP7B1 | 9208 |
| PTGIS | 2628 |
| HSD3B7 | 1740 |
| CYP27A1 | 1195 |
| RXRA | -1906 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| NCOA1 | 15583 |
| AKR1C2 | 15531 |
| AKR1C3 | 15390 |
| AKR1D1 | 15342 |
| NCOA2 | 15265 |
| AKR1C4 | 14564 |
| AKR1C1 | 14333 |
| NR1H4 | 12633 |
| CYP7A1 | 12478 |
| CYP8B1 | 10099 |
| CYP7B1 | 9208 |
| PTGIS | 2628 |
| HSD3B7 | 1740 |
| CYP27A1 | 1195 |
| RXRA | -1906 |
DCC mediated attractive signaling
| 259 | |
|---|---|
| set | DCC mediated attractive signaling |
| setSize | 14 |
| pANOVA | 0.000193 |
| s.dist | 0.575 |
| p.adjustANOVA | 0.00138 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| PTK2 | 15782 |
| TRIO | 15766 |
| DOCK1 | 15439 |
| FYN | 14272 |
| NCK1 | 14257 |
| DCC | 13727 |
| ABLIM3 | 12619 |
| ABLIM1 | 11876 |
| ABLIM2 | 10701 |
| NTN1 | 8370 |
| SRC | 4703 |
| WASL | 3908 |
| RAC1 | 1076 |
| CDC42 | 962 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| PTK2 | 15782 |
| TRIO | 15766 |
| DOCK1 | 15439 |
| FYN | 14272 |
| NCK1 | 14257 |
| DCC | 13727 |
| ABLIM3 | 12619 |
| ABLIM1 | 11876 |
| ABLIM2 | 10701 |
| NTN1 | 8370 |
| SRC | 4703 |
| WASL | 3908 |
| RAC1 | 1076 |
| CDC42 | 962 |
Response of EIF2AK4 (GCN2) to amino acid deficiency
| 1135 | |
|---|---|
| set | Response of EIF2AK4 (GCN2) to amino acid deficiency |
| setSize | 95 |
| pANOVA | 4.94e-22 |
| s.dist | -0.572 |
| p.adjustANOVA | 4.44e-20 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| CEBPG | -9250 |
| RPL36 | -9233 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| CEBPG | -9250.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| EIF2S2 | -8003.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| CEBPB | -7773.0 |
| ATF4 | -7704.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| DDIT3 | -6954.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| ATF2 | -5069.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| RPS20 | -4527.0 |
| RPL21 | -4286.5 |
| ATF3 | -4261.0 |
| EIF2S1 | -4046.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| ASNS | 2135.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| RPL3 | 5754.0 |
| EIF2AK4 | 6684.0 |
| RPL10L | 6857.0 |
| TRIB3 | 8224.0 |
| RPL5 | 9083.0 |
| GCN1 | 10616.0 |
| IMPACT | 12000.0 |
| RPL3L | 12071.0 |
SRP-dependent cotranslational protein targeting to membrane
| 1172 | |
|---|---|
| set | SRP-dependent cotranslational protein targeting to membrane |
| setSize | 105 |
| pANOVA | 3.69e-24 |
| s.dist | -0.572 |
| p.adjustANOVA | 4.7e-22 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| SPCS1 | -10230 |
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| SRP14 | -10144 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| SPCS1 | -10230.0 |
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| SRP14 | -10144.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| SEC61B | -9161.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| SRP9 | -7871.0 |
| RPS10 | -7813.0 |
| SRP72 | -7731.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| SSR2 | -7018.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| SEC11A | -6846.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| SRP54 | -6183.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| DDOST | -5044.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| SPCS2 | -4530.0 |
| RPS20 | -4527.0 |
| RPL21 | -4286.5 |
| SRP19 | -4114.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| TRAM1 | -2622.0 |
| SSR1 | -2503.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPN2 | -2030.0 |
| RPS11 | -1912.0 |
| SEC61G | -1902.0 |
| SEC61A1 | -1826.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| RPN1 | 0.5 |
| RPS17 | 0.5 |
| SEC11C | 963.0 |
| RPL24 | 988.0 |
| SRPRB | 1026.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| SPCS3 | 3642.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| RPL3 | 5754.0 |
| RPL10L | 6857.0 |
| SRP68 | 7534.0 |
| SSR3 | 7603.0 |
| SEC61A2 | 9001.0 |
| RPL5 | 9083.0 |
| RPL3L | 12071.0 |
Formation of a pool of free 40S subunits
| 449 | |
|---|---|
| set | Formation of a pool of free 40S subunits |
| setSize | 95 |
| pANOVA | 5.45e-21 |
| s.dist | -0.557 |
| p.adjustANOVA | 3.47e-19 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| RPL36 | -9233 |
| RPL7 | -9178 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| EIF3K | -6837.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| EIF3G | -6552.0 |
| RPS3A | -6470.0 |
| EIF3J | -6294.0 |
| EIF3I | -5845.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| EIF3C | -5092.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| EIF3B | -4720.0 |
| RPS20 | -4527.0 |
| RPL21 | -4286.5 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| EIF3D | 1054.0 |
| EIF3F | 1102.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| EIF3L | 2402.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| EIF3A | 5614.0 |
| RPL3 | 5754.0 |
| RPL10L | 6857.0 |
| EIF3E | 7984.0 |
| EIF3M | 8158.0 |
| RPL5 | 9083.0 |
| RPL3L | 12071.0 |
| EIF3H | 13890.0 |
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
| 822 | |
|---|---|
| set | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| setSize | 89 |
| pANOVA | 2.28e-19 |
| s.dist | -0.551 |
| p.adjustANOVA | 1.2e-17 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| RPL36 | -9233 |
| RPL7 | -9178 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| NCBP1 | -5821.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| RPS20 | -4527.0 |
| RPL21 | -4286.5 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| NCBP2 | -3568.0 |
| RPS29 | -3270.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| ETF1 | 5376.0 |
| RPL3 | 5754.0 |
| UPF1 | 6379.0 |
| RPL10L | 6857.0 |
| RPL5 | 9083.0 |
| EIF4G1 | 10468.0 |
| PABPC1 | 11193.0 |
| RPL3L | 12071.0 |
| GSPT1 | 14967.0 |
SARS-CoV-2 modulates host translation machinery
| 1154 | |
|---|---|
| set | SARS-CoV-2 modulates host translation machinery |
| setSize | 46 |
| pANOVA | 2.58e-10 |
| s.dist | -0.538 |
| p.adjustANOVA | 8.4e-09 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| SNRPD2 | -10187 |
| RPS21 | -10161 |
| RPS25 | -9987 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| DDX20 | -9480 |
| RPS2 | -9318 |
| SNRPD1 | -8977 |
| RPS16 | -8804 |
| RPS28 | -8415 |
| RPS18 | -8283 |
| RPS19 | -8195 |
| RPS27 | -7955 |
| SNRPF | -7885 |
| RPS10 | -7813 |
| SNRPG | -7713 |
| RPS14 | -7696 |
| GEMIN5 | -7657 |
| RPS26 | -6894 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| SNRPD2 | -10187.0 |
| RPS21 | -10161.0 |
| RPS25 | -9987.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| DDX20 | -9480.0 |
| RPS2 | -9318.0 |
| SNRPD1 | -8977.0 |
| RPS16 | -8804.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPS27 | -7955.0 |
| SNRPF | -7885.0 |
| RPS10 | -7813.0 |
| SNRPG | -7713.0 |
| RPS14 | -7696.0 |
| GEMIN5 | -7657.0 |
| RPS26 | -6894.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| GEMIN4 | -5667.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| RPS20 | -4527.0 |
| GEMIN6 | -4035.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| SNRPD3 | -3874.0 |
| RPS29 | -3270.0 |
| RPS13 | -2416.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPS11 | -1912.0 |
| RPS9 | -1389.0 |
| GEMIN2 | 0.5 |
| RPS17 | 0.5 |
| RPS3 | 1211.0 |
| RPS15A | 2520.0 |
| RPS24 | 4526.0 |
| SNRPE | 6022.0 |
| GEMIN7 | 9769.0 |
| SMN1 | 9828.5 |
| SNRPB | 13469.0 |
GTP hydrolysis and joining of the 60S ribosomal subunit
| 493 | |
|---|---|
| set | GTP hydrolysis and joining of the 60S ribosomal subunit |
| setSize | 105 |
| pANOVA | 1.69e-21 |
| s.dist | -0.537 |
| p.adjustANOVA | 1.17e-19 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| RPL36 | -9233 |
| RPL7 | -9178 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| EIF2S2 | -8003.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| EIF3K | -6837.0 |
| RPL39L | -6811.0 |
| EIF5 | -6750.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| EIF3G | -6552.0 |
| RPS3A | -6470.0 |
| EIF3J | -6294.0 |
| EIF3I | -5845.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| EIF3C | -5092.0 |
| EIF4E | -5005.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| EIF3B | -4720.0 |
| EIF4A2 | -4629.0 |
| RPS20 | -4527.0 |
| RPL21 | -4286.5 |
| EIF2S1 | -4046.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| EIF4B | -3180.0 |
| RPS13 | -2416.0 |
| EIF5B | -2340.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| EIF3D | 1054.0 |
| EIF3F | 1102.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| EIF3L | 2402.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| EIF4A1 | 2690.0 |
| EIF4H | 3415.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| EIF3A | 5614.0 |
| RPL3 | 5754.0 |
| RPL10L | 6857.0 |
| EIF3E | 7984.0 |
| EIF3M | 8158.0 |
| RPL5 | 9083.0 |
| EIF4G1 | 10468.0 |
| RPL3L | 12071.0 |
| EIF3H | 13890.0 |
Recycling of bile acids and salts
| 1065 | |
|---|---|
| set | Recycling of bile acids and salts |
| setSize | 18 |
| pANOVA | 9.04e-05 |
| s.dist | 0.533 |
| p.adjustANOVA | 0.000694 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| NCOA1 | 15583 |
| SLCO1A2 | 15368 |
| NCOA2 | 15265 |
| SLCO1B3 | 14946 |
| ALB | 14627 |
| BAAT | 14454 |
| ABCB11 | 14033 |
| NR1H4 | 12633 |
| SLC10A2 | 11778 |
| SLC10A1 | 11487 |
| FABP6 | 10460 |
| SLC27A5 | 7520 |
| SLCO1B1 | 7417 |
| SLC51A | 6057 |
| SLC51B | 5204 |
| ABCC3 | 1800 |
| RXRA | -1906 |
| STARD5 | -2281 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| NCOA1 | 15583 |
| SLCO1A2 | 15368 |
| NCOA2 | 15265 |
| SLCO1B3 | 14946 |
| ALB | 14627 |
| BAAT | 14454 |
| ABCB11 | 14033 |
| NR1H4 | 12633 |
| SLC10A2 | 11778 |
| SLC10A1 | 11487 |
| FABP6 | 10460 |
| SLC27A5 | 7520 |
| SLCO1B1 | 7417 |
| SLC51A | 6057 |
| SLC51B | 5204 |
| ABCC3 | 1800 |
| RXRA | -1906 |
| STARD5 | -2281 |
L13a-mediated translational silencing of Ceruloplasmin expression
| 660 | |
|---|---|
| set | L13a-mediated translational silencing of Ceruloplasmin expression |
| setSize | 104 |
| pANOVA | 1.9e-20 |
| s.dist | -0.525 |
| p.adjustANOVA | 1.11e-18 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| RPL36 | -9233 |
| RPL7 | -9178 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| EIF2S2 | -8003.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| EIF3K | -6837.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| EIF3G | -6552.0 |
| RPS3A | -6470.0 |
| EIF3J | -6294.0 |
| EIF3I | -5845.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| EIF3C | -5092.0 |
| EIF4E | -5005.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| EIF3B | -4720.0 |
| EIF4A2 | -4629.0 |
| RPS20 | -4527.0 |
| RPL21 | -4286.5 |
| EIF2S1 | -4046.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| EIF4B | -3180.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| EIF3D | 1054.0 |
| EIF3F | 1102.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| EIF3L | 2402.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| EIF4A1 | 2690.0 |
| EIF4H | 3415.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| EIF3A | 5614.0 |
| RPL3 | 5754.0 |
| RPL10L | 6857.0 |
| EIF3E | 7984.0 |
| EIF3M | 8158.0 |
| RPL5 | 9083.0 |
| EIF4G1 | 10468.0 |
| PABPC1 | 11193.0 |
| RPL3L | 12071.0 |
| EIF3H | 13890.0 |
Cap-dependent Translation Initiation
| 165 | |
|---|---|
| set | Cap-dependent Translation Initiation |
| setSize | 112 |
| pANOVA | 1.21e-21 |
| s.dist | -0.522 |
| p.adjustANOVA | 9.26e-20 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| EIF2B4 | -10208 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| RPL36 | -9233 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| EIF2B4 | -10208.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| EIF2S2 | -8003.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| EIF3K | -6837.0 |
| RPL39L | -6811.0 |
| EIF5 | -6750.0 |
| EIF2B5 | -6715.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| EIF3G | -6552.0 |
| RPS3A | -6470.0 |
| EIF3J | -6294.0 |
| EIF3I | -5845.0 |
| FAU | -5597.0 |
| EIF4EBP1 | -5218.0 |
| RPS12 | -5167.0 |
| EIF3C | -5092.0 |
| EIF4E | -5005.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| EIF3B | -4720.0 |
| EIF4A2 | -4629.0 |
| RPS20 | -4527.0 |
| RPL21 | -4286.5 |
| EIF2S1 | -4046.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| EIF4B | -3180.0 |
| RPS13 | -2416.0 |
| EIF5B | -2340.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| EIF2B2 | -1153.0 |
| EIF2B1 | -1048.0 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| EIF3D | 1054.0 |
| EIF3F | 1102.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| EIF3L | 2402.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| EIF4A1 | 2690.0 |
| EIF4H | 3415.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| EIF2B3 | 5550.0 |
| EIF3A | 5614.0 |
| RPL3 | 5754.0 |
| RPL10L | 6857.0 |
| EIF3E | 7984.0 |
| EIF3M | 8158.0 |
| RPL5 | 9083.0 |
| EIF4G1 | 10468.0 |
| PABPC1 | 11193.0 |
| RPL3L | 12071.0 |
| EIF3H | 13890.0 |
Eukaryotic Translation Initiation
| 396 | |
|---|---|
| set | Eukaryotic Translation Initiation |
| setSize | 112 |
| pANOVA | 1.21e-21 |
| s.dist | -0.522 |
| p.adjustANOVA | 9.26e-20 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| EIF2B4 | -10208 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| RPL36 | -9233 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| EIF2B4 | -10208.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| EIF2S2 | -8003.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| EIF3K | -6837.0 |
| RPL39L | -6811.0 |
| EIF5 | -6750.0 |
| EIF2B5 | -6715.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| EIF3G | -6552.0 |
| RPS3A | -6470.0 |
| EIF3J | -6294.0 |
| EIF3I | -5845.0 |
| FAU | -5597.0 |
| EIF4EBP1 | -5218.0 |
| RPS12 | -5167.0 |
| EIF3C | -5092.0 |
| EIF4E | -5005.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| EIF3B | -4720.0 |
| EIF4A2 | -4629.0 |
| RPS20 | -4527.0 |
| RPL21 | -4286.5 |
| EIF2S1 | -4046.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPS29 | -3270.0 |
| EIF4B | -3180.0 |
| RPS13 | -2416.0 |
| EIF5B | -2340.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| EIF2B2 | -1153.0 |
| EIF2B1 | -1048.0 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| EIF3D | 1054.0 |
| EIF3F | 1102.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| EIF3L | 2402.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| EIF4A1 | 2690.0 |
| EIF4H | 3415.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| EIF2B3 | 5550.0 |
| EIF3A | 5614.0 |
| RPL3 | 5754.0 |
| RPL10L | 6857.0 |
| EIF3E | 7984.0 |
| EIF3M | 8158.0 |
| RPL5 | 9083.0 |
| EIF4G1 | 10468.0 |
| PABPC1 | 11193.0 |
| RPL3L | 12071.0 |
| EIF3H | 13890.0 |
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
| 1334 | |
|---|---|
| set | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| setSize | 24 |
| pANOVA | 1.1e-05 |
| s.dist | 0.518 |
| p.adjustANOVA | 0.000106 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| NCOA1 | 15583 |
| AKR1C2 | 15531 |
| AKR1C3 | 15390 |
| AKR1D1 | 15342 |
| NCOA2 | 15265 |
| AKR1C4 | 14564 |
| BAAT | 14454 |
| AKR1C1 | 14333 |
| ABCB11 | 14033 |
| NR1H4 | 12633 |
| CYP7A1 | 12478 |
| HSD17B4 | 11834 |
| ACOX2 | 10569 |
| CYP8B1 | 10099 |
| SCP2 | 9490 |
| CYP7B1 | 9208 |
| SLC27A5 | 7520 |
| SLC27A2 | 7009 |
| PTGIS | 2628 |
| ACOT8 | 2156 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| NCOA1 | 15583 |
| AKR1C2 | 15531 |
| AKR1C3 | 15390 |
| AKR1D1 | 15342 |
| NCOA2 | 15265 |
| AKR1C4 | 14564 |
| BAAT | 14454 |
| AKR1C1 | 14333 |
| ABCB11 | 14033 |
| NR1H4 | 12633 |
| CYP7A1 | 12478 |
| HSD17B4 | 11834 |
| ACOX2 | 10569 |
| CYP8B1 | 10099 |
| SCP2 | 9490 |
| CYP7B1 | 9208 |
| SLC27A5 | 7520 |
| SLC27A2 | 7009 |
| PTGIS | 2628 |
| ACOT8 | 2156 |
| HSD3B7 | 1740 |
| CYP27A1 | 1195 |
| RXRA | -1906 |
| AMACR | -3175 |
Formation of the ternary complex, and subsequently, the 43S complex
| 455 | |
|---|---|
| set | Formation of the ternary complex, and subsequently, the 43S complex |
| setSize | 47 |
| pANOVA | 2.93e-09 |
| s.dist | -0.5 |
| p.adjustANOVA | 7.72e-08 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPS21 | -10161 |
| RPS25 | -9987 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPS2 | -9318 |
| RPS16 | -8804 |
| RPS28 | -8415 |
| RPS18 | -8283 |
| RPS19 | -8195 |
| EIF2S2 | -8003 |
| RPS27 | -7955 |
| RPS10 | -7813 |
| RPS14 | -7696 |
| RPS26 | -6894 |
| EIF3K | -6837 |
| RPS15 | -6628 |
| RPS8 | -6576 |
| EIF3G | -6552 |
| RPS3A | -6470 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPS21 | -10161.0 |
| RPS25 | -9987.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPS2 | -9318.0 |
| RPS16 | -8804.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| EIF2S2 | -8003.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPS26 | -6894.0 |
| EIF3K | -6837.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| EIF3G | -6552.0 |
| RPS3A | -6470.0 |
| EIF3J | -6294.0 |
| EIF3I | -5845.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| EIF3C | -5092.0 |
| EIF3B | -4720.0 |
| RPS20 | -4527.0 |
| EIF2S1 | -4046.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPS29 | -3270.0 |
| RPS13 | -2416.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPS11 | -1912.0 |
| RPS9 | -1389.0 |
| RPS17 | 0.5 |
| EIF3D | 1054.0 |
| EIF3F | 1102.0 |
| RPS3 | 1211.0 |
| EIF3L | 2402.0 |
| RPS15A | 2520.0 |
| RPS24 | 4526.0 |
| EIF3A | 5614.0 |
| EIF3E | 7984.0 |
| EIF3M | 8158.0 |
| EIF3H | 13890.0 |
Class C/3 (Metabotropic glutamate/pheromone receptors)
| 212 | |
|---|---|
| set | Class C/3 (Metabotropic glutamate/pheromone receptors) |
| setSize | 39 |
| pANOVA | 7.16e-08 |
| s.dist | 0.498 |
| p.adjustANOVA | 1.29e-06 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| GRM5 | 14995 |
| GRM7 | 14989 |
| TAS2R3 | 14632 |
| GABBR1 | 14511 |
| GRM8 | 14456 |
| TAS2R31 | 14173 |
| TAS2R50 | 13742 |
| TAS2R7 | 13492 |
| TAS2R38 | 13432 |
| TAS2R60 | 12999 |
| GPRC6A | 12994 |
| TAS2R1 | 12784 |
| TAS2R30 | 12331 |
| TAS2R39 | 11889 |
| TAS2R20 | 11789 |
| TAS2R8 | 11225 |
| TAS2R41 | 10689 |
| TAS2R5 | 10613 |
| TAS2R19 | 9726 |
| GRM1 | 9415 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| GRM5 | 14995.0 |
| GRM7 | 14989.0 |
| TAS2R3 | 14632.0 |
| GABBR1 | 14511.0 |
| GRM8 | 14456.0 |
| TAS2R31 | 14173.0 |
| TAS2R50 | 13742.0 |
| TAS2R7 | 13492.0 |
| TAS2R38 | 13432.0 |
| TAS2R60 | 12999.0 |
| GPRC6A | 12994.0 |
| TAS2R1 | 12784.0 |
| TAS2R30 | 12331.0 |
| TAS2R39 | 11889.0 |
| TAS2R20 | 11789.0 |
| TAS2R8 | 11225.0 |
| TAS2R41 | 10689.0 |
| TAS2R5 | 10613.0 |
| TAS2R19 | 9726.0 |
| GRM1 | 9415.0 |
| TAS2R40 | 8962.0 |
| TAS2R46 | 8898.0 |
| TAS2R43 | 8404.0 |
| GABBR2 | 8393.0 |
| TAS2R9 | 7792.0 |
| GRM2 | 7322.0 |
| TAS2R14 | 7044.0 |
| TAS2R10 | 7013.0 |
| TAS2R13 | 6500.0 |
| TAS1R1 | 5978.0 |
| TAS2R16 | 5439.0 |
| GRM4 | 4483.0 |
| TAS1R3 | 4109.0 |
| TAS1R2 | 4065.0 |
| CASR | 3902.0 |
| GRM6 | 3900.0 |
| GRM3 | 3055.0 |
| TAS2R4 | 0.5 |
| TAS2R42 | 0.5 |
NGF-stimulated transcription
| 773 | |
|---|---|
| set | NGF-stimulated transcription |
| setSize | 39 |
| pANOVA | 1.01e-07 |
| s.dist | -0.492 |
| p.adjustANOVA | 1.68e-06 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| CDK5R2 | -10329 |
| EGR3 | -10265 |
| FOS | -10211 |
| NAB2 | -10194 |
| JUNB | -10151 |
| ID2 | -10137 |
| CDK5 | -9963 |
| ID1 | -9472 |
| ASCL1 | -9201 |
| ID4 | -8849 |
| JUND | -8829 |
| SRF | -8752 |
| REST | -8503 |
| FOSL1 | -8497 |
| VGF | -8235 |
| ID3 | -8199 |
| LYL1 | -8017 |
| EGR1 | -7937 |
| TRIB1 | -7603 |
| FOSB | -7245 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| CDK5R2 | -10329 |
| EGR3 | -10265 |
| FOS | -10211 |
| NAB2 | -10194 |
| JUNB | -10151 |
| ID2 | -10137 |
| CDK5 | -9963 |
| ID1 | -9472 |
| ASCL1 | -9201 |
| ID4 | -8849 |
| JUND | -8829 |
| SRF | -8752 |
| REST | -8503 |
| FOSL1 | -8497 |
| VGF | -8235 |
| ID3 | -8199 |
| LYL1 | -8017 |
| EGR1 | -7937 |
| TRIB1 | -7603 |
| FOSB | -7245 |
| F3 | -6490 |
| MEF2D | -6480 |
| ARC | -6432 |
| DNM2 | -5402 |
| ATF2 | -5069 |
| EGR4 | -4451 |
| RRAD | -4343 |
| ATF1 | -4337 |
| EGR2 | -3739 |
| EP300 | -937 |
| CDK5R1 | 2797 |
| CREB1 | 4365 |
| TF | 5688 |
| NAB1 | 8777 |
| SH3GL3 | 8964 |
| SGK1 | 11679 |
| CHD4 | 13162 |
| TPH1 | 13182 |
| TCF12 | 15438 |
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
| 821 | |
|---|---|
| set | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| setSize | 108 |
| pANOVA | 2.54e-18 |
| s.dist | -0.486 |
| p.adjustANOVA | 1.21e-16 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| PNRC2 | -9935 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| MAGOH | -9436 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| PNRC2 | -9935.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| MAGOH | -9436.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| PPP2CA | -8630.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| SMG7 | -7370.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| PPP2R1A | -6077.0 |
| NCBP1 | -5821.0 |
| UPF3A | -5612.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| RPS20 | -4527.0 |
| MAGOHB | -4431.0 |
| RPL21 | -4286.5 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| NCBP2 | -3568.0 |
| RBM8A | -3284.0 |
| RPS29 | -3270.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| CASC3 | 0.5 |
| SMG8 | 0.5 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| RNPS1 | 3116.0 |
| EIF4A3 | 3126.0 |
| SMG5 | 3449.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| UPF2 | 5023.0 |
| ETF1 | 5376.0 |
| RPL3 | 5754.0 |
| SMG1 | 5910.0 |
| UPF1 | 6379.0 |
| RPL10L | 6857.0 |
| DCP1A | 8691.0 |
| RPL5 | 9083.0 |
| PPP2R2A | 9529.0 |
| EIF4G1 | 10468.0 |
| PABPC1 | 11193.0 |
| SMG9 | 12027.0 |
| RPL3L | 12071.0 |
| SMG6 | 12075.0 |
| GSPT1 | 14967.0 |
Nonsense-Mediated Decay (NMD)
| 823 | |
|---|---|
| set | Nonsense-Mediated Decay (NMD) |
| setSize | 108 |
| pANOVA | 2.54e-18 |
| s.dist | -0.486 |
| p.adjustANOVA | 1.21e-16 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| PNRC2 | -9935 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| MAGOH | -9436 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| PNRC2 | -9935.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| MAGOH | -9436.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| PPP2CA | -8630.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| SMG7 | -7370.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| PPP2R1A | -6077.0 |
| NCBP1 | -5821.0 |
| UPF3A | -5612.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| RPS20 | -4527.0 |
| MAGOHB | -4431.0 |
| RPL21 | -4286.5 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| NCBP2 | -3568.0 |
| RBM8A | -3284.0 |
| RPS29 | -3270.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| CASC3 | 0.5 |
| SMG8 | 0.5 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| RNPS1 | 3116.0 |
| EIF4A3 | 3126.0 |
| SMG5 | 3449.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| UPF2 | 5023.0 |
| ETF1 | 5376.0 |
| RPL3 | 5754.0 |
| SMG1 | 5910.0 |
| UPF1 | 6379.0 |
| RPL10L | 6857.0 |
| DCP1A | 8691.0 |
| RPL5 | 9083.0 |
| PPP2R2A | 9529.0 |
| EIF4G1 | 10468.0 |
| PABPC1 | 11193.0 |
| SMG9 | 12027.0 |
| RPL3L | 12071.0 |
| SMG6 | 12075.0 |
| GSPT1 | 14967.0 |
Selenoamino acid metabolism
| 1192 | |
|---|---|
| set | Selenoamino acid metabolism |
| setSize | 103 |
| pANOVA | 1.6e-17 |
| s.dist | -0.485 |
| p.adjustANOVA | 7.42e-16 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| RPL19 | -9282 |
| RPL36 | -9233 |
| RPL7 | -9178 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| AIMP1 | -6644.0 |
| RPS15 | -6628.0 |
| AHCY | -6589.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| GSR | -5669.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| RPL37 | -4995.0 |
| RPL22 | -4836.0 |
| RPS20 | -4527.0 |
| SEPSECS | -4437.0 |
| RPL21 | -4286.5 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| CBS | -3482.0 |
| CTH | -3294.0 |
| RPS29 | -3270.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| PAPSS1 | -1586.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| SEPHS2 | 0.5 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| SECISBP2 | 2881.0 |
| GNMT | 3382.0 |
| AIMP2 | 3450.0 |
| UBA52 | 4002.0 |
| SCLY | 4132.0 |
| RPS24 | 4526.0 |
| PSTK | 5284.0 |
| PAPSS2 | 5368.0 |
| RPL3 | 5754.0 |
| INMT | 6014.0 |
| MAT1A | 6062.0 |
| RPL10L | 6857.0 |
| TXNRD1 | 8112.0 |
| RPL5 | 9083.0 |
| NNMT | 11301.0 |
| RPL3L | 12071.0 |
| EEF1E1 | 12885.0 |
| HNMT | 14149.0 |
| EEFSEC | 14214.0 |
Activation of the phototransduction cascade
| 56 | |
|---|---|
| set | Activation of the phototransduction cascade |
| setSize | 11 |
| pANOVA | 0.00564 |
| s.dist | 0.482 |
| p.adjustANOVA | 0.0242 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| CNGA1 | 15178 |
| PDE6A | 14593 |
| SAG | 12785 |
| GNB1 | 12455 |
| SLC24A1 | 12327 |
| GNAT1 | 12014 |
| GNGT1 | 11448 |
| RHO | 6852 |
| CNGB1 | 3359 |
| PDE6G | 2401 |
| PDE6B | -4113 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| CNGA1 | 15178 |
| PDE6A | 14593 |
| SAG | 12785 |
| GNB1 | 12455 |
| SLC24A1 | 12327 |
| GNAT1 | 12014 |
| GNGT1 | 11448 |
| RHO | 6852 |
| CNGB1 | 3359 |
| PDE6G | 2401 |
| PDE6B | -4113 |
Major pathway of rRNA processing in the nucleolus and cytosol
| 699 | |
|---|---|
| set | Major pathway of rRNA processing in the nucleolus and cytosol |
| setSize | 171 |
| pANOVA | 1.34e-26 |
| s.dist | -0.472 |
| p.adjustANOVA | 2.27e-24 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| EXOSC4 | -10281 |
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| EXOSC8 | -10117 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| WDR75 | -9782 |
| RPL23A | -9774 |
| UTP15 | -9739 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| MPHOSPH10 | -9420 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| EXOSC4 | -10281.0 |
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| EXOSC8 | -10117.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| WDR75 | -9782.0 |
| RPL23A | -9774.0 |
| UTP15 | -9739.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| MPHOSPH10 | -9420.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| EXOSC5 | -9303.0 |
| RPL19 | -9282.0 |
| IMP3 | -9272.0 |
| RPL36 | -9233.0 |
| BYSL | -9202.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RIOK2 | -9065.0 |
| UTP3 | -9058.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RRP9 | -7991.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPP25 | -7785.0 |
| RPS14 | -7696.0 |
| FTSJ3 | -7683.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPP21 | -7416.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| NIP7 | -7225.0 |
| XRN2 | -7218.0 |
| RPL34 | -7211.0 |
| IMP4 | -7196.0 |
| DCAF13 | -7160.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| DDX21 | -6681.0 |
| ISG20L2 | -6649.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| EXOSC6 | -6520.0 |
| KRR1 | -6514.0 |
| RPS3A | -6470.0 |
| NOL11 | -6466.0 |
| NOL6 | -6451.0 |
| LTV1 | -6374.0 |
| EXOSC3 | -6277.0 |
| RPP38 | -6225.0 |
| WDR3 | -6043.0 |
| UTP20 | -6008.0 |
| FAU | -5597.0 |
| CSNK1E | -5549.0 |
| NOL12 | -5455.0 |
| TBL3 | -5314.0 |
| RPS12 | -5167.0 |
| DDX52 | -5162.0 |
| MPHOSPH6 | -5161.0 |
| EMG1 | -5053.0 |
| RPL37 | -4995.0 |
| RRP7A | -4860.0 |
| RPL22 | -4836.0 |
| RPS20 | -4527.0 |
| WDR12 | -4438.0 |
| RPL21 | -4286.5 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPP30 | -3627.0 |
| NOP56 | -3456.0 |
| PNO1 | -3388.0 |
| UTP6 | -3339.0 |
| SENP3 | -3325.0 |
| RPS29 | -3270.0 |
| PES1 | -3238.0 |
| EXOSC9 | -2880.0 |
| EXOSC1 | -2875.0 |
| WDR36 | -2858.0 |
| RIOK1 | -2646.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| EXOSC2 | -2291.0 |
| TSR1 | -2284.0 |
| RPS7 | -2277.0 |
| EBNA1BP2 | -2256.0 |
| RPP40 | -2189.0 |
| WDR46 | -2155.0 |
| RPLP1 | -2105.0 |
| EXOSC7 | -2066.0 |
| PWP2 | -2044.0 |
| RPS11 | -1912.0 |
| WDR18 | -1859.0 |
| WBSCR22 | -1824.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| PDCD11 | -1508.0 |
| RPL31 | -1504.0 |
| RBM28 | -1491.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| UTP18 | -1271.0 |
| DDX49 | -1102.0 |
| C1D | 0.5 |
| RRP36 | 0.5 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RRP1 | 1254.0 |
| RIOK3 | 1457.0 |
| FCF1 | 1747.0 |
| RPL13A | 2429.5 |
| RPP14 | 2476.0 |
| RPS15A | 2520.0 |
| BMS1 | 2907.0 |
| FBL | 3179.0 |
| NOB1 | 3391.0 |
| DIS3 | 3729.0 |
| UBA52 | 4002.0 |
| SNU13 | 4246.0 |
| RCL1 | 4267.0 |
| RPS24 | 4526.0 |
| NOP14 | 4941.0 |
| NCL | 5278.0 |
| RPL3 | 5754.0 |
| GNL3 | 6209.0 |
| DDX47 | 6602.0 |
| PELP1 | 6680.0 |
| RPL10L | 6857.0 |
| EXOSC10 | 6941.0 |
| NOP58 | 7355.0 |
| NOC4L | 8352.0 |
| NOL9 | 8452.0 |
| TEX10 | 8622.0 |
| BOP1 | 8779.0 |
| WDR43 | 8987.0 |
| RPL5 | 9083.0 |
| ERI1 | 9377.0 |
| HEATR1 | 10396.0 |
| DHX37 | 11434.0 |
| RPL3L | 12071.0 |
| CSNK1D | 12711.0 |
| UTP14C | 15409.0 |
Influenza Viral RNA Transcription and Replication
| 594 | |
|---|---|
| set | Influenza Viral RNA Transcription and Replication |
| setSize | 129 |
| pANOVA | 1.95e-20 |
| s.dist | -0.472 |
| p.adjustANOVA | 1.11e-18 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| NUP43 | -9970 |
| RPL23A | -9774 |
| POLR2E | -9725 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
| RPL10A | -9405 |
| RPS2 | -9318 |
| POLR2K | -9286 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| NUP43 | -9970.0 |
| RPL23A | -9774.0 |
| POLR2E | -9725.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| POLR2K | -9286.0 |
| RPL19 | -9282.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| POLR2I | -8858.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| POLR2D | -8627.0 |
| NUP37 | -8563.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| NUP155 | -7942.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| GRSF1 | -7458.0 |
| RPL29 | -7452.0 |
| HSP90AA1 | -7396.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| POLR2L | -7252.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| RPS3A | -6470.0 |
| NUP153 | -6133.0 |
| NUP205 | -5965.0 |
| NUP62 | -5685.0 |
| FAU | -5597.0 |
| NUP88 | -5278.0 |
| RPS12 | -5167.0 |
| RPL37 | -4995.0 |
| POLR2A | -4855.0 |
| RPL22 | -4836.0 |
| NUP188 | -4812.0 |
| POLR2C | -4568.0 |
| RPS20 | -4527.0 |
| POLR2F | -4384.0 |
| RPL21 | -4286.5 |
| POLR2J | -4265.0 |
| NUP133 | -3997.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| POM121C | -3409.0 |
| RPS29 | -3270.0 |
| NUP50 | -3069.0 |
| POLR2H | -2985.0 |
| NUP85 | -2966.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| NUP160 | -2148.0 |
| RPLP1 | -2105.0 |
| RPS11 | -1912.0 |
| POLR2B | -1847.0 |
| SEH1L | -1822.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| POM121 | -1308.0 |
| NUP35 | 0.5 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| GTF2F1 | 1304.0 |
| DNAJC3 | 1650.0 |
| NUP107 | 1875.0 |
| RANBP2 | 2229.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| POLR2G | 3829.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| RPL3 | 5754.0 |
| TPR | 6045.0 |
| AAAS | 6483.0 |
| RAE1 | 6613.0 |
| RPL10L | 6857.0 |
| NUP54 | 7342.0 |
| RPL5 | 9083.0 |
| SEC13 | 9448.0 |
| NDC1 | 11373.0 |
| GTF2F2 | 11813.0 |
| RPL3L | 12071.0 |
| PARP1 | 12250.0 |
| NUP98 | 12638.0 |
| NUP93 | 12815.0 |
| NUP210 | 13592.0 |
| NUP214 | 13775.0 |
| IPO5 | 15271.0 |
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
| 884 | |
|---|---|
| set | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation |
| setSize | 10 |
| pANOVA | 0.00978 |
| s.dist | -0.472 |
| p.adjustANOVA | 0.0386 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| CDX2 | -10330 |
| GSC | -9974 |
| EOMES | -8148 |
| SOX2 | -7809 |
| TSC22D1 | -7189 |
| DKK1 | -7028 |
| HHEX | -4874 |
| GATA6 | -4826 |
| POU5F1 | 12104 |
| NANOG | 13738 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| CDX2 | -10330 |
| GSC | -9974 |
| EOMES | -8148 |
| SOX2 | -7809 |
| TSC22D1 | -7189 |
| DKK1 | -7028 |
| HHEX | -4874 |
| GATA6 | -4826 |
| POU5F1 | 12104 |
| NANOG | 13738 |
SCF(Skp2)-mediated degradation of p27/p21
| 1157 | |
|---|---|
| set | SCF(Skp2)-mediated degradation of p27/p21 |
| setSize | 58 |
| pANOVA | 5.6e-10 |
| s.dist | -0.47 |
| p.adjustANOVA | 1.78e-08 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| CDKN1B | -10339 |
| RPS27A | -10227 |
| PSMA5 | -10158 |
| CCNA1 | -9890 |
| PSME1 | -9684 |
| CCNA2 | -9341 |
| PSMB5 | -9332 |
| PSMB8 | -9134 |
| CKS1B | -9120 |
| PSMA7 | -8854 |
| PSMC5 | -8758 |
| PSMB3 | -8486 |
| PSMA2 | -8250 |
| UBC | -8113 |
| PSME3 | -8046 |
| PSMD7 | -7531 |
| PSMB6 | -7292 |
| CCNE2 | -7017 |
| PSMD3 | -6333 |
| PSMB9 | -6219 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| CDKN1B | -10339.0 |
| RPS27A | -10227.0 |
| PSMA5 | -10158.0 |
| CCNA1 | -9890.0 |
| PSME1 | -9684.0 |
| CCNA2 | -9341.0 |
| PSMB5 | -9332.0 |
| PSMB8 | -9134.0 |
| CKS1B | -9120.0 |
| PSMA7 | -8854.0 |
| PSMC5 | -8758.0 |
| PSMB3 | -8486.0 |
| PSMA2 | -8250.0 |
| UBC | -8113.0 |
| PSME3 | -8046.0 |
| PSMD7 | -7531.0 |
| PSMB6 | -7292.0 |
| CCNE2 | -7017.0 |
| PSMD3 | -6333.0 |
| PSMB9 | -6219.0 |
| PSMC3 | -6201.0 |
| CCNE1 | -6025.0 |
| PSMB10 | -5878.0 |
| CDK4 | -5758.0 |
| CCND1 | -5650.0 |
| PSMC2 | -5452.0 |
| PSMC4 | -5411.0 |
| PSMA3 | -5280.0 |
| PSMD4 | -5220.0 |
| PSMC1 | -4896.0 |
| PSMA6 | -4821.0 |
| PSMD5 | -4653.0 |
| PSME2 | -4583.0 |
| UBB | -4405.0 |
| PSMC6 | -4037.0 |
| SKP1 | -3845.0 |
| PSMD13 | -3810.0 |
| PSMB4 | -3750.0 |
| PSMB1 | -3384.0 |
| CDK2 | -3347.0 |
| PSMB2 | -3084.0 |
| PSMD12 | -2133.0 |
| PSMD8 | -1983.0 |
| PSMA4 | -1392.0 |
| CDKN1A | 0.5 |
| PSMD2 | 2186.0 |
| PSMA1 | 2379.0 |
| PSMD11 | 3512.0 |
| UBA52 | 4002.0 |
| PSMD6 | 4531.0 |
| PTK6 | 5634.0 |
| PSMB7 | 6029.0 |
| PSMD9 | 6185.0 |
| SKP2 | 6254.0 |
| PSMF1 | 8157.0 |
| PSMD14 | 8247.0 |
| CUL1 | 11156.0 |
| PSMD1 | 11303.0 |
Inhibition of DNA recombination at telomere
| 596 | |
|---|---|
| set | Inhibition of DNA recombination at telomere |
| setSize | 20 |
| pANOVA | 0.00027 |
| s.dist | -0.47 |
| p.adjustANOVA | 0.00185 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| TERF2IP | -9827.0 |
| POLR2E | -9725.0 |
| POLR2K | -9286.0 |
| TINF2 | -9129.0 |
| POLR2I | -8858.0 |
| POLR2D | -8627.0 |
| H2AFX | -7312.0 |
| POLR2L | -7252.0 |
| DAXX | -6731.0 |
| POLR2A | -4855.0 |
| POLR2C | -4568.0 |
| POLR2F | -4384.0 |
| POLR2J | -4265.0 |
| ACD | -3199.5 |
| POLR2H | -2985.0 |
| POLR2B | -1847.0 |
| POLR2G | 3829.0 |
| POT1 | 6789.0 |
| TERF2 | 11486.0 |
| TERF1 | 12470.0 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| TERF2IP | -9827.0 |
| POLR2E | -9725.0 |
| POLR2K | -9286.0 |
| TINF2 | -9129.0 |
| POLR2I | -8858.0 |
| POLR2D | -8627.0 |
| H2AFX | -7312.0 |
| POLR2L | -7252.0 |
| DAXX | -6731.0 |
| POLR2A | -4855.0 |
| POLR2C | -4568.0 |
| POLR2F | -4384.0 |
| POLR2J | -4265.0 |
| ACD | -3199.5 |
| POLR2H | -2985.0 |
| POLR2B | -1847.0 |
| POLR2G | 3829.0 |
| POT1 | 6789.0 |
| TERF2 | 11486.0 |
| TERF1 | 12470.0 |
ERKs are inactivated
| 375 | |
|---|---|
| set | ERKs are inactivated |
| setSize | 13 |
| pANOVA | 0.00338 |
| s.dist | -0.469 |
| p.adjustANOVA | 0.0159 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| DUSP6 | -10239 |
| MAPK7 | -9415 |
| PPP2R5D | -8994 |
| PPP2CA | -8630 |
| DUSP7 | -7826 |
| PPP2R1A | -6077 |
| MAPK3 | -5863 |
| DUSP4 | -5581 |
| VRK3 | -4985 |
| DUSP3 | -2961 |
| MAPK1 | 2412 |
| PPP2R1B | 10895 |
| PPP2CB | 13042 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| DUSP6 | -10239 |
| MAPK7 | -9415 |
| PPP2R5D | -8994 |
| PPP2CA | -8630 |
| DUSP7 | -7826 |
| PPP2R1A | -6077 |
| MAPK3 | -5863 |
| DUSP4 | -5581 |
| VRK3 | -4985 |
| DUSP3 | -2961 |
| MAPK1 | 2412 |
| PPP2R1B | 10895 |
| PPP2CB | 13042 |
Ribosomal scanning and start codon recognition
| 1145 | |
|---|---|
| set | Ribosomal scanning and start codon recognition |
| setSize | 54 |
| pANOVA | 2.9e-09 |
| s.dist | -0.467 |
| p.adjustANOVA | 7.72e-08 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPS21 | -10161 |
| RPS25 | -9987 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPS2 | -9318 |
| RPS16 | -8804 |
| RPS28 | -8415 |
| RPS18 | -8283 |
| RPS19 | -8195 |
| EIF2S2 | -8003 |
| RPS27 | -7955 |
| RPS10 | -7813 |
| RPS14 | -7696 |
| RPS26 | -6894 |
| EIF3K | -6837 |
| EIF5 | -6750 |
| RPS15 | -6628 |
| RPS8 | -6576 |
| EIF3G | -6552 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPS21 | -10161.0 |
| RPS25 | -9987.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPS2 | -9318.0 |
| RPS16 | -8804.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| EIF2S2 | -8003.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPS26 | -6894.0 |
| EIF3K | -6837.0 |
| EIF5 | -6750.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| EIF3G | -6552.0 |
| RPS3A | -6470.0 |
| EIF3J | -6294.0 |
| EIF3I | -5845.0 |
| FAU | -5597.0 |
| RPS12 | -5167.0 |
| EIF3C | -5092.0 |
| EIF4E | -5005.0 |
| EIF3B | -4720.0 |
| EIF4A2 | -4629.0 |
| RPS20 | -4527.0 |
| EIF2S1 | -4046.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPS29 | -3270.0 |
| EIF4B | -3180.0 |
| RPS13 | -2416.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPS11 | -1912.0 |
| RPS9 | -1389.0 |
| RPS17 | 0.5 |
| EIF3D | 1054.0 |
| EIF3F | 1102.0 |
| RPS3 | 1211.0 |
| EIF3L | 2402.0 |
| RPS15A | 2520.0 |
| EIF4A1 | 2690.0 |
| EIF4H | 3415.0 |
| RPS24 | 4526.0 |
| EIF3A | 5614.0 |
| EIF3E | 7984.0 |
| EIF3M | 8158.0 |
| EIF4G1 | 10468.0 |
| EIF3H | 13890.0 |
rRNA processing in the nucleus and cytosol
| 1522 | |
|---|---|
| set | rRNA processing in the nucleus and cytosol |
| setSize | 180 |
| pANOVA | 9.85e-27 |
| s.dist | -0.462 |
| p.adjustANOVA | 1.88e-24 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| TRMT112 | -10337 |
| EXOSC4 | -10281 |
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| EXOSC8 | -10117 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| WDR75 | -9782 |
| RPL23A | -9774 |
| UTP15 | -9739 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| RPL27 | -9426 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| TRMT112 | -10337.0 |
| EXOSC4 | -10281.0 |
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| EXOSC8 | -10117.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| WDR75 | -9782.0 |
| RPL23A | -9774.0 |
| UTP15 | -9739.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| MPHOSPH10 | -9420.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| EXOSC5 | -9303.0 |
| RPL19 | -9282.0 |
| IMP3 | -9272.0 |
| RPL36 | -9233.0 |
| BYSL | -9202.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RIOK2 | -9065.0 |
| UTP3 | -9058.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| TSR3 | -8588.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RRP9 | -7991.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPP25 | -7785.0 |
| RPS14 | -7696.0 |
| FTSJ3 | -7683.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPP21 | -7416.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| GAR1 | -7242.0 |
| NIP7 | -7225.0 |
| XRN2 | -7218.0 |
| RPL34 | -7211.0 |
| IMP4 | -7196.0 |
| DCAF13 | -7160.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| DDX21 | -6681.0 |
| ISG20L2 | -6649.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| EXOSC6 | -6520.0 |
| KRR1 | -6514.0 |
| RPS3A | -6470.0 |
| NOL11 | -6466.0 |
| NOL6 | -6451.0 |
| LTV1 | -6374.0 |
| EXOSC3 | -6277.0 |
| RPP38 | -6225.0 |
| WDR3 | -6043.0 |
| UTP20 | -6008.0 |
| FAU | -5597.0 |
| CSNK1E | -5549.0 |
| NOL12 | -5455.0 |
| TBL3 | -5314.0 |
| RPS12 | -5167.0 |
| DDX52 | -5162.0 |
| MPHOSPH6 | -5161.0 |
| EMG1 | -5053.0 |
| RPL37 | -4995.0 |
| RRP7A | -4860.0 |
| RPL22 | -4836.0 |
| RPS20 | -4527.0 |
| WDR12 | -4438.0 |
| RPL21 | -4286.5 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPP30 | -3627.0 |
| NOP56 | -3456.0 |
| PNO1 | -3388.0 |
| UTP6 | -3339.0 |
| SENP3 | -3325.0 |
| RPS29 | -3270.0 |
| PES1 | -3238.0 |
| NOP2 | -3024.0 |
| EXOSC9 | -2880.0 |
| EXOSC1 | -2875.0 |
| WDR36 | -2858.0 |
| RIOK1 | -2646.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| EXOSC2 | -2291.0 |
| TSR1 | -2284.0 |
| RPS7 | -2277.0 |
| EBNA1BP2 | -2256.0 |
| RPP40 | -2189.0 |
| WDR46 | -2155.0 |
| RPLP1 | -2105.0 |
| EXOSC7 | -2066.0 |
| PWP2 | -2044.0 |
| RPS11 | -1912.0 |
| WDR18 | -1859.0 |
| WBSCR22 | -1824.0 |
| THUMPD1 | -1798.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| PDCD11 | -1508.0 |
| RPL31 | -1504.0 |
| RBM28 | -1491.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| UTP18 | -1271.0 |
| DDX49 | -1102.0 |
| C1D | 0.5 |
| RRP36 | 0.5 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RRP1 | 1254.0 |
| NHP2 | 1431.0 |
| RIOK3 | 1457.0 |
| FCF1 | 1747.0 |
| RPL13A | 2429.5 |
| RPP14 | 2476.0 |
| RPS15A | 2520.0 |
| BMS1 | 2907.0 |
| FBL | 3179.0 |
| NOB1 | 3391.0 |
| DIS3 | 3729.0 |
| UBA52 | 4002.0 |
| SNU13 | 4246.0 |
| RCL1 | 4267.0 |
| RPS24 | 4526.0 |
| NOP14 | 4941.0 |
| NCL | 5278.0 |
| RPL3 | 5754.0 |
| GNL3 | 6209.0 |
| DDX47 | 6602.0 |
| PELP1 | 6680.0 |
| NOP10 | 6776.0 |
| RPL10L | 6857.0 |
| EXOSC10 | 6941.0 |
| NOP58 | 7355.0 |
| NAT10 | 8005.0 |
| NOC4L | 8352.0 |
| NOL9 | 8452.0 |
| TEX10 | 8622.0 |
| BOP1 | 8779.0 |
| WDR43 | 8987.0 |
| RPL5 | 9083.0 |
| ERI1 | 9377.0 |
| DIMT1 | 9439.0 |
| HEATR1 | 10396.0 |
| DHX37 | 11434.0 |
| RPL3L | 12071.0 |
| CSNK1D | 12711.0 |
| UTP14C | 15409.0 |
Intrinsic Pathway of Fibrin Clot Formation
| 643 | |
|---|---|
| set | Intrinsic Pathway of Fibrin Clot Formation |
| setSize | 21 |
| pANOVA | 0.000268 |
| s.dist | 0.459 |
| p.adjustANOVA | 0.00185 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| A2M | 15654 |
| VWF | 14878 |
| KNG1 | 14379 |
| SERPINE2 | 14258 |
| PROS1 | 14202 |
| KLKB1 | 13368 |
| SERPIND1 | 13252 |
| SERPINC1 | 13006 |
| F2 | 11959 |
| SERPING1 | 10486 |
| F10 | 10216 |
| PROC | 8766 |
| GP5 | 8088 |
| F11 | 7896 |
| GP1BA | 5638 |
| F12 | 4542 |
| SERPINA5 | 3095 |
| C1QBP | 1812 |
| GP9 | 1597 |
| PRCP | 1425 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| A2M | 15654 |
| VWF | 14878 |
| KNG1 | 14379 |
| SERPINE2 | 14258 |
| PROS1 | 14202 |
| KLKB1 | 13368 |
| SERPIND1 | 13252 |
| SERPINC1 | 13006 |
| F2 | 11959 |
| SERPING1 | 10486 |
| F10 | 10216 |
| PROC | 8766 |
| GP5 | 8088 |
| F11 | 7896 |
| GP1BA | 5638 |
| F12 | 4542 |
| SERPINA5 | 3095 |
| C1QBP | 1812 |
| GP9 | 1597 |
| PRCP | 1425 |
| GP1BB | -5209 |
Regulation of expression of SLITs and ROBOs
| 1105 | |
|---|---|
| set | Regulation of expression of SLITs and ROBOs |
| setSize | 159 |
| pANOVA | 1.46e-23 |
| s.dist | -0.459 |
| p.adjustANOVA | 1.59e-21 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| LHX9 | -10340 |
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| PSMA5 | -10158 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| ISL1 | -9934 |
| RPL23A | -9774 |
| RPL41 | -9703 |
| PSME1 | -9684 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
| MAGOH | -9436 |
| RPL27 | -9426 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| LHX9 | -10340.0 |
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| PSMA5 | -10158.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| ISL1 | -9934.0 |
| RPL23A | -9774.0 |
| RPL41 | -9703.0 |
| PSME1 | -9684.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| MAGOH | -9436.0 |
| RPL27 | -9426.0 |
| RPL10A | -9405.0 |
| PSMB5 | -9332.0 |
| RPS2 | -9318.0 |
| RPL19 | -9282.0 |
| MSI1 | -9273.0 |
| RPL36 | -9233.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| LDB1 | -9136.0 |
| PSMB8 | -9134.0 |
| RPL35 | -9133.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| PSMA7 | -8854.0 |
| RPS16 | -8804.0 |
| PSMC5 | -8758.0 |
| RPL27A | -8637.0 |
| PSMB3 | -8486.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| PSMA2 | -8250.0 |
| RPS19 | -8195.0 |
| UBC | -8113.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| PSME3 | -8046.0 |
| RPL11 | -8002.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPL18A | -7611.0 |
| PSMD7 | -7531.0 |
| RPL29 | -7452.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| PSMB6 | -7292.0 |
| RPL26L1 | -7263.0 |
| RPL34 | -7211.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| ROBO3 | -6789.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| LHX4 | -6532.0 |
| RPS3A | -6470.0 |
| PSMD3 | -6333.0 |
| PSMB9 | -6219.0 |
| PSMC3 | -6201.0 |
| PSMB10 | -5878.0 |
| NCBP1 | -5821.0 |
| LHX3 | -5625.0 |
| UPF3A | -5612.0 |
| FAU | -5597.0 |
| PSMC2 | -5452.0 |
| PSMC4 | -5411.0 |
| PSMA3 | -5280.0 |
| PSMD4 | -5220.0 |
| RPS12 | -5167.0 |
| RPL37 | -4995.0 |
| PSMC1 | -4896.0 |
| RPL22 | -4836.0 |
| PSMA6 | -4821.0 |
| PSMD5 | -4653.0 |
| PSME2 | -4583.0 |
| RPS20 | -4527.0 |
| MAGOHB | -4431.0 |
| UBB | -4405.0 |
| RPL21 | -4286.5 |
| RBX1 | -4278.0 |
| PSMC6 | -4037.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| PSMD13 | -3810.0 |
| PSMB4 | -3750.0 |
| NCBP2 | -3568.0 |
| PSMB1 | -3384.0 |
| LHX2 | -3334.0 |
| RBM8A | -3284.0 |
| RPS29 | -3270.0 |
| PSMB2 | -3084.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| PSMD12 | -2133.0 |
| RPLP1 | -2105.0 |
| PSMD8 | -1983.0 |
| RPS11 | -1912.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| RPL31 | -1504.0 |
| PSMA4 | -1392.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| ZSWIM8 | 0.5 |
| CASC3 | 0.5 |
| RPS17 | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| PSMD2 | 2186.0 |
| PSMA1 | 2379.0 |
| RPL13A | 2429.5 |
| RPS15A | 2520.0 |
| RNPS1 | 3116.0 |
| EIF4A3 | 3126.0 |
| USP33 | 3484.0 |
| PSMD11 | 3512.0 |
| PSMB11 | 3936.0 |
| UBA52 | 4002.0 |
| RPS24 | 4526.0 |
| PSMD6 | 4531.0 |
| UPF2 | 5023.0 |
| HOXA2 | 5133.0 |
| PSME4 | 5136.0 |
| ETF1 | 5376.0 |
| SLIT1 | 5546.0 |
| RPL3 | 5754.0 |
| PSMB7 | 6029.0 |
| PSMD9 | 6185.0 |
| RPL10L | 6857.0 |
| PSMF1 | 8157.0 |
| PSMD14 | 8247.0 |
| RPL5 | 9083.0 |
| EIF4G1 | 10468.0 |
| PABPC1 | 11193.0 |
| PSMD1 | 11303.0 |
| RPL3L | 12071.0 |
| CUL2 | 12230.0 |
| DAG1 | 14131.0 |
| ROBO1 | 14467.0 |
| SLIT2 | 14755.0 |
| GSPT1 | 14967.0 |
| ROBO2 | 15063.0 |
| PSMA8 | 15244.0 |
Mitochondrial translation initiation
| 745 | |
|---|---|
| set | Mitochondrial translation initiation |
| setSize | 87 |
| pANOVA | 2.04e-13 |
| s.dist | -0.455 |
| p.adjustANOVA | 7.99e-12 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MRPL41 | -10260 |
| MRPL17 | -10157 |
| MRPL54 | -10079 |
| MRPL36 | -10054 |
| MRPS12 | -9957 |
| MRPL50 | -9841 |
| MRPS11 | -9745 |
| MRPL46 | -9737 |
| MTIF3 | -9383 |
| MRPL39 | -9323 |
| MRPL57 | -9163 |
| MRPL51 | -9126 |
| MRPS26 | -9012 |
| MRPS18B | -8816 |
| MRPS2 | -8592 |
| MRPL2 | -8528 |
| MRPL18 | -8525 |
| MRPS18C | -8310 |
| MRPL32 | -8179 |
| AURKAIP1 | -8029 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MRPL41 | -10260.0 |
| MRPL17 | -10157.0 |
| MRPL54 | -10079.0 |
| MRPL36 | -10054.0 |
| MRPS12 | -9957.0 |
| MRPL50 | -9841.0 |
| MRPS11 | -9745.0 |
| MRPL46 | -9737.0 |
| MTIF3 | -9383.0 |
| MRPL39 | -9323.0 |
| MRPL57 | -9163.0 |
| MRPL51 | -9126.0 |
| MRPS26 | -9012.0 |
| MRPS18B | -8816.0 |
| MRPS2 | -8592.0 |
| MRPL2 | -8528.0 |
| MRPL18 | -8525.0 |
| MRPS18C | -8310.0 |
| MRPL32 | -8179.0 |
| AURKAIP1 | -8029.0 |
| MRPS36 | -7925.0 |
| MRPL55 | -7783.0 |
| MRPS34 | -7774.0 |
| MRPS30 | -7665.0 |
| MRPL47 | -7608.0 |
| OXA1L | -7581.0 |
| MRPS7 | -7385.0 |
| MRPL24 | -7055.0 |
| MRPS15 | -6964.0 |
| CHCHD1 | -6957.0 |
| MRPS16 | -6918.0 |
| MRPL12 | -6707.0 |
| MRPL53 | -6602.0 |
| MRPL43 | -6419.0 |
| MRPL30 | -6418.0 |
| MRPL10 | -6147.0 |
| MRPL37 | -5856.0 |
| GADD45GIP1 | -5648.0 |
| MRPS17 | -5644.0 |
| MRPL44 | -5586.0 |
| MRPL21 | -5475.0 |
| MRPS24 | -5418.0 |
| MRPL27 | -5003.0 |
| MRPL34 | -4662.0 |
| MRPS31 | -4339.0 |
| MRPL40 | -4158.0 |
| MRPS23 | -4000.0 |
| MRPS33 | -3741.0 |
| MRPS35 | -3732.0 |
| MRPL14 | -3547.0 |
| MRPL49 | -3473.0 |
| MRPL4 | -3331.0 |
| MRPS10 | -3202.0 |
| MRPL42 | -3139.0 |
| MTIF2 | -3050.0 |
| MRPS5 | -2949.0 |
| MTFMT | -2849.0 |
| PTCD3 | -2052.0 |
| MRPL35 | -1780.0 |
| MRPL1 | -1713.0 |
| MRPL3 | -1693.0 |
| MRPL15 | 0.5 |
| MRPL33 | 1057.0 |
| ERAL1 | 1112.0 |
| MRPL52 | 1209.0 |
| MRPL20 | 1379.0 |
| DAP3 | 1678.0 |
| MRPL38 | 2518.0 |
| MRPS21 | 2627.0 |
| MRPL13 | 2725.0 |
| MRPS22 | 2752.0 |
| MRPL28 | 3316.0 |
| MRPS18A | 3348.0 |
| MRPL9 | 3445.0 |
| MRPS25 | 4177.0 |
| MRPS14 | 4187.0 |
| MRPL11 | 4570.0 |
| MRPS9 | 4784.0 |
| MRPL19 | 4973.0 |
| MRPL23 | 5021.0 |
| MRPL16 | 5442.0 |
| MRPS28 | 7840.0 |
| MRPS6 | 8050.0 |
| MRPL48 | 8508.0 |
| MRPL45 | 9812.0 |
| MRPL22 | 9861.0 |
| MRPS27 | 11908.0 |
Regulation of commissural axon pathfinding by SLIT and ROBO
| 1104 | |
|---|---|
| set | Regulation of commissural axon pathfinding by SLIT and ROBO |
| setSize | 10 |
| pANOVA | 0.0127 |
| s.dist | 0.455 |
| p.adjustANOVA | 0.0477 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| ROBO2 | 15063 |
| SLIT3 | 14795 |
| SLIT2 | 14755 |
| ROBO1 | 14467 |
| DCC | 13727 |
| NTN1 | 8370 |
| SLIT1 | 5546 |
| SRC | 4703 |
| NELL2 | 2150 |
| ROBO3 | -6789 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| ROBO2 | 15063 |
| SLIT3 | 14795 |
| SLIT2 | 14755 |
| ROBO1 | 14467 |
| DCC | 13727 |
| NTN1 | 8370 |
| SLIT1 | 5546 |
| SRC | 4703 |
| NELL2 | 2150 |
| ROBO3 | -6789 |
Transcriptional regulation of testis differentiation
| 1426 | |
|---|---|
| set | Transcriptional regulation of testis differentiation |
| setSize | 12 |
| pANOVA | 0.00647 |
| s.dist | -0.454 |
| p.adjustANOVA | 0.0272 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| FOXL2 | -10319 |
| WT1 | -10264 |
| SOX9 | -9917 |
| DHH | -9838 |
| DMRT1 | -9579 |
| GATA4 | -8988 |
| FGF9 | -4185 |
| PTGDS | -1523 |
| WNT4 | 1019 |
| NR5A1 | 3216 |
| AMH | 6516 |
| ZFPM2 | 15460 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| FOXL2 | -10319 |
| WT1 | -10264 |
| SOX9 | -9917 |
| DHH | -9838 |
| DMRT1 | -9579 |
| GATA4 | -8988 |
| FGF9 | -4185 |
| PTGDS | -1523 |
| WNT4 | 1019 |
| NR5A1 | 3216 |
| AMH | 6516 |
| ZFPM2 | 15460 |
RNA Polymerase III Chain Elongation
| 1033 | |
|---|---|
| set | RNA Polymerase III Chain Elongation |
| setSize | 18 |
| pANOVA | 0.000907 |
| s.dist | -0.452 |
| p.adjustANOVA | 0.00517 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| POLR3GL | -10025.0 |
| POLR2E | -9725.0 |
| POLR2K | -9286.0 |
| POLR1C | -8420.0 |
| POLR2L | -7252.0 |
| POLR3D | -7100.0 |
| POLR3H | -6937.0 |
| POLR3G | -6875.0 |
| POLR3K | -5807.0 |
| POLR3C | -5243.0 |
| POLR2F | -4384.0 |
| POLR2H | -2985.0 |
| POLR1D | -2271.0 |
| POLR3F | 0.5 |
| POLR3E | 992.0 |
| POLR3B | 5658.0 |
| CRCP | 9390.0 |
| POLR3A | 13224.0 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| POLR3GL | -10025.0 |
| POLR2E | -9725.0 |
| POLR2K | -9286.0 |
| POLR1C | -8420.0 |
| POLR2L | -7252.0 |
| POLR3D | -7100.0 |
| POLR3H | -6937.0 |
| POLR3G | -6875.0 |
| POLR3K | -5807.0 |
| POLR3C | -5243.0 |
| POLR2F | -4384.0 |
| POLR2H | -2985.0 |
| POLR1D | -2271.0 |
| POLR3F | 0.5 |
| POLR3E | 992.0 |
| POLR3B | 5658.0 |
| CRCP | 9390.0 |
| POLR3A | 13224.0 |
Mitochondrial translation termination
| 746 | |
|---|---|
| set | Mitochondrial translation termination |
| setSize | 87 |
| pANOVA | 3.48e-13 |
| s.dist | -0.451 |
| p.adjustANOVA | 1.33e-11 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MRPL41 | -10260 |
| MRPL17 | -10157 |
| MRPL54 | -10079 |
| MRPL36 | -10054 |
| MRPS12 | -9957 |
| MRPL50 | -9841 |
| MTRF1L | -9817 |
| MRPS11 | -9745 |
| MRPL46 | -9737 |
| MRPL39 | -9323 |
| MRPL57 | -9163 |
| MRPL51 | -9126 |
| MRPS26 | -9012 |
| MRPS18B | -8816 |
| MRPS2 | -8592 |
| MRPL2 | -8528 |
| MRPL18 | -8525 |
| MRPS18C | -8310 |
| MRPL32 | -8179 |
| AURKAIP1 | -8029 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MRPL41 | -10260.0 |
| MRPL17 | -10157.0 |
| MRPL54 | -10079.0 |
| MRPL36 | -10054.0 |
| MRPS12 | -9957.0 |
| MRPL50 | -9841.0 |
| MTRF1L | -9817.0 |
| MRPS11 | -9745.0 |
| MRPL46 | -9737.0 |
| MRPL39 | -9323.0 |
| MRPL57 | -9163.0 |
| MRPL51 | -9126.0 |
| MRPS26 | -9012.0 |
| MRPS18B | -8816.0 |
| MRPS2 | -8592.0 |
| MRPL2 | -8528.0 |
| MRPL18 | -8525.0 |
| MRPS18C | -8310.0 |
| MRPL32 | -8179.0 |
| AURKAIP1 | -8029.0 |
| MRPS36 | -7925.0 |
| MRPL55 | -7783.0 |
| MRPS34 | -7774.0 |
| MRPS30 | -7665.0 |
| MRPL47 | -7608.0 |
| OXA1L | -7581.0 |
| MRPS7 | -7385.0 |
| MRPL24 | -7055.0 |
| MRPS15 | -6964.0 |
| CHCHD1 | -6957.0 |
| MRPS16 | -6918.0 |
| MRPL12 | -6707.0 |
| MRPL53 | -6602.0 |
| MRPL43 | -6419.0 |
| MRPL30 | -6418.0 |
| GFM2 | -6263.0 |
| MRPL10 | -6147.0 |
| MRPL37 | -5856.0 |
| GADD45GIP1 | -5648.0 |
| MRPS17 | -5644.0 |
| MRPL44 | -5586.0 |
| MRPL21 | -5475.0 |
| MRPS24 | -5418.0 |
| MRPL27 | -5003.0 |
| MRPL34 | -4662.0 |
| MRPS31 | -4339.0 |
| MRPL40 | -4158.0 |
| MRPS23 | -4000.0 |
| MRPS33 | -3741.0 |
| MRPS35 | -3732.0 |
| MRPL14 | -3547.0 |
| MRPL49 | -3473.0 |
| MRPL4 | -3331.0 |
| MRPS10 | -3202.0 |
| MRPL42 | -3139.0 |
| MRPS5 | -2949.0 |
| PTCD3 | -2052.0 |
| MRPL35 | -1780.0 |
| MRPL1 | -1713.0 |
| MRPL3 | -1693.0 |
| MRPL15 | 0.5 |
| MRPL33 | 1057.0 |
| ERAL1 | 1112.0 |
| MRPL52 | 1209.0 |
| MRPL20 | 1379.0 |
| DAP3 | 1678.0 |
| MRPL38 | 2518.0 |
| MRPS21 | 2627.0 |
| MRPL13 | 2725.0 |
| MRPS22 | 2752.0 |
| MRPL28 | 3316.0 |
| MRPS18A | 3348.0 |
| MRPL9 | 3445.0 |
| MRPS25 | 4177.0 |
| MRPS14 | 4187.0 |
| MRPL11 | 4570.0 |
| MRPS9 | 4784.0 |
| MRPL19 | 4973.0 |
| MRPL23 | 5021.0 |
| MRPL16 | 5442.0 |
| MRRF | 5837.0 |
| MRPS28 | 7840.0 |
| MRPS6 | 8050.0 |
| MRPL48 | 8508.0 |
| MRPL45 | 9812.0 |
| MRPL22 | 9861.0 |
| MRPS27 | 11908.0 |
rRNA processing
| 1521 | |
|---|---|
| set | rRNA processing |
| setSize | 186 |
| pANOVA | 4.3e-26 |
| s.dist | -0.448 |
| p.adjustANOVA | 6.58e-24 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| TRMT112 | -10337 |
| EXOSC4 | -10281 |
| RPS27A | -10227 |
| RPL28 | -10222 |
| RPS21 | -10161 |
| EXOSC8 | -10117 |
| RPL15 | -10104 |
| RPL12 | -10024 |
| RPS25 | -9987 |
| WDR75 | -9782 |
| RPL23A | -9774 |
| UTP15 | -9739 |
| RPL41 | -9703 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| MRM1 | -9614 |
| RPL36AL | -9587 |
| RPL23 | -9582 |
| RPLP2 | -9524 |
| RPL14 | -9498 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| TRMT112 | -10337.0 |
| EXOSC4 | -10281.0 |
| RPS27A | -10227.0 |
| RPL28 | -10222.0 |
| RPS21 | -10161.0 |
| EXOSC8 | -10117.0 |
| RPL15 | -10104.0 |
| RPL12 | -10024.0 |
| RPS25 | -9987.0 |
| WDR75 | -9782.0 |
| RPL23A | -9774.0 |
| UTP15 | -9739.0 |
| RPL41 | -9703.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| MRM1 | -9614.0 |
| RPL36AL | -9587.0 |
| RPL23 | -9582.0 |
| RPLP2 | -9524.0 |
| RPL14 | -9498.0 |
| RPL27 | -9426.0 |
| MPHOSPH10 | -9420.0 |
| RPL10A | -9405.0 |
| RPS2 | -9318.0 |
| EXOSC5 | -9303.0 |
| RPL19 | -9282.0 |
| IMP3 | -9272.0 |
| RPL36 | -9233.0 |
| BYSL | -9202.0 |
| RPL7 | -9178.0 |
| RPLP0 | -9142.0 |
| RPL35 | -9133.0 |
| RIOK2 | -9065.0 |
| UTP3 | -9058.0 |
| RPL32 | -9038.0 |
| RPL26 | -9033.0 |
| RPL18 | -8916.0 |
| RPS16 | -8804.0 |
| RPL27A | -8637.0 |
| TSR3 | -8588.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| RPL17 | -8109.0 |
| RPL37A | -8068.0 |
| RPL11 | -8002.0 |
| RRP9 | -7991.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPP25 | -7785.0 |
| RPS14 | -7696.0 |
| FTSJ3 | -7683.0 |
| RPL18A | -7611.0 |
| RPL29 | -7452.0 |
| RPP21 | -7416.0 |
| RPL22L1 | -7362.0 |
| RPL35A | -7318.0 |
| RPL26L1 | -7263.0 |
| GAR1 | -7242.0 |
| NIP7 | -7225.0 |
| XRN2 | -7218.0 |
| RPL34 | -7211.0 |
| IMP4 | -7196.0 |
| DCAF13 | -7160.0 |
| RPL6 | -7044.0 |
| RPS26 | -6894.0 |
| RPL30 | -6868.0 |
| RPL39L | -6811.0 |
| DDX21 | -6681.0 |
| ISG20L2 | -6649.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| EXOSC6 | -6520.0 |
| KRR1 | -6514.0 |
| RPS3A | -6470.0 |
| NOL11 | -6466.0 |
| NOL6 | -6451.0 |
| LTV1 | -6374.0 |
| EXOSC3 | -6277.0 |
| RPP38 | -6225.0 |
| WDR3 | -6043.0 |
| UTP20 | -6008.0 |
| FAU | -5597.0 |
| CSNK1E | -5549.0 |
| NOL12 | -5455.0 |
| TBL3 | -5314.0 |
| RPS12 | -5167.0 |
| DDX52 | -5162.0 |
| MPHOSPH6 | -5161.0 |
| EMG1 | -5053.0 |
| RPL37 | -4995.0 |
| RRP7A | -4860.0 |
| RPL22 | -4836.0 |
| RPS20 | -4527.0 |
| WDR12 | -4438.0 |
| RPL21 | -4286.5 |
| NSUN4 | -4117.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPL9 | -3875.0 |
| RPP30 | -3627.0 |
| NOP56 | -3456.0 |
| PNO1 | -3388.0 |
| UTP6 | -3339.0 |
| SENP3 | -3325.0 |
| RPS29 | -3270.0 |
| PES1 | -3238.0 |
| NOP2 | -3024.0 |
| EXOSC9 | -2880.0 |
| EXOSC1 | -2875.0 |
| WDR36 | -2858.0 |
| RIOK1 | -2646.0 |
| RPS13 | -2416.0 |
| RPL13 | -2328.0 |
| RPS6 | -2305.0 |
| EXOSC2 | -2291.0 |
| TSR1 | -2284.0 |
| RPS7 | -2277.0 |
| EBNA1BP2 | -2256.0 |
| RPP40 | -2189.0 |
| WDR46 | -2155.0 |
| RPLP1 | -2105.0 |
| EXOSC7 | -2066.0 |
| PWP2 | -2044.0 |
| RPS11 | -1912.0 |
| WDR18 | -1859.0 |
| WBSCR22 | -1824.0 |
| THUMPD1 | -1798.0 |
| RPL38 | -1742.0 |
| RPL4 | -1652.0 |
| PDCD11 | -1508.0 |
| RPL31 | -1504.0 |
| RBM28 | -1491.0 |
| RPS9 | -1389.0 |
| RPL7A | -1375.0 |
| UTP18 | -1271.0 |
| DDX49 | -1102.0 |
| C1D | 0.5 |
| RRP36 | 0.5 |
| RPS17 | 0.5 |
| TRMT10C | 0.5 |
| RPL24 | 988.0 |
| RPL8 | 1168.0 |
| RPS3 | 1211.0 |
| RRP1 | 1254.0 |
| NHP2 | 1431.0 |
| RIOK3 | 1457.0 |
| FCF1 | 1747.0 |
| RPL13A | 2429.5 |
| RPP14 | 2476.0 |
| RPS15A | 2520.0 |
| BMS1 | 2907.0 |
| FBL | 3179.0 |
| ELAC2 | 3181.0 |
| NOB1 | 3391.0 |
| DIS3 | 3729.0 |
| UBA52 | 4002.0 |
| SNU13 | 4246.0 |
| RCL1 | 4267.0 |
| RPS24 | 4526.0 |
| NOP14 | 4941.0 |
| NCL | 5278.0 |
| RPL3 | 5754.0 |
| GNL3 | 6209.0 |
| DDX47 | 6602.0 |
| PELP1 | 6680.0 |
| NOP10 | 6776.0 |
| RPL10L | 6857.0 |
| EXOSC10 | 6941.0 |
| NOP58 | 7355.0 |
| NAT10 | 8005.0 |
| NOC4L | 8352.0 |
| NOL9 | 8452.0 |
| TEX10 | 8622.0 |
| BOP1 | 8779.0 |
| WDR43 | 8987.0 |
| RPL5 | 9083.0 |
| ERI1 | 9377.0 |
| DIMT1 | 9439.0 |
| MTERF4 | 9905.0 |
| HEATR1 | 10396.0 |
| DHX37 | 11434.0 |
| RPL3L | 12071.0 |
| CSNK1D | 12711.0 |
| TFB1M | 13379.0 |
| UTP14C | 15409.0 |
Folding of actin by CCT/TriC
| 441 | |
|---|---|
| set | Folding of actin by CCT/TriC |
| setSize | 10 |
| pANOVA | 0.0147 |
| s.dist | -0.445 |
| p.adjustANOVA | 0.0531 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| ACTB | -10333 |
| CCT3 | -6408 |
| CCT7 | -5623 |
| CCT8 | -5275 |
| CCT6B | -5135 |
| CCT6A | -4844 |
| CCT5 | -3106 |
| TCP1 | -1319 |
| CCT4 | 5291 |
| CCT2 | 5849 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| ACTB | -10333 |
| CCT3 | -6408 |
| CCT7 | -5623 |
| CCT8 | -5275 |
| CCT6B | -5135 |
| CCT6A | -4844 |
| CCT5 | -3106 |
| TCP1 | -1319 |
| CCT4 | 5291 |
| CCT2 | 5849 |
Digestion and absorption
| 317 | |
|---|---|
| set | Digestion and absorption |
| setSize | 26 |
| pANOVA | 8.58e-05 |
| s.dist | 0.445 |
| p.adjustANOVA | 0.000669 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MGAM | 15264 |
| PNLIP | 14625 |
| LCT | 14248 |
| SLC2A5 | 14200 |
| AMY2B | 14112 |
| LIPF | 13884 |
| CHIA | 13855 |
| PNLIPRP3 | 13439 |
| AMY2A | 12239 |
| CHIT1 | 9664 |
| NPC1L1 | 9631 |
| RSC1A1 | 9586 |
| GUCY2C | 8576 |
| AMY1B | 8406 |
| AMY1C | 8406 |
| AMY1A | 8406 |
| SLC2A2 | 5959 |
| PNLIPRP1 | 4937 |
| ALPI | 4297 |
| CLPS | 4240 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MGAM | 15264 |
| PNLIP | 14625 |
| LCT | 14248 |
| SLC2A5 | 14200 |
| AMY2B | 14112 |
| LIPF | 13884 |
| CHIA | 13855 |
| PNLIPRP3 | 13439 |
| AMY2A | 12239 |
| CHIT1 | 9664 |
| NPC1L1 | 9631 |
| RSC1A1 | 9586 |
| GUCY2C | 8576 |
| AMY1B | 8406 |
| AMY1C | 8406 |
| AMY1A | 8406 |
| SLC2A2 | 5959 |
| PNLIPRP1 | 4937 |
| ALPI | 4297 |
| CLPS | 4240 |
| PNLIPRP2 | 4189 |
| TREH | 3800 |
| SLC5A1 | 3637 |
| GUCA2B | 2969 |
| GUCA2A | 2264 |
| CEL | -2784 |
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
| 55 | |
|---|---|
| set | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| setSize | 55 |
| pANOVA | 1.17e-08 |
| s.dist | -0.444 |
| p.adjustANOVA | 2.79e-07 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| RPS21 | -10161 |
| RPS25 | -9987 |
| RPS27L | -9625 |
| RPS23 | -9619 |
| RPS2 | -9318 |
| RPS16 | -8804 |
| RPS28 | -8415 |
| RPS18 | -8283 |
| RPS19 | -8195 |
| EIF2S2 | -8003 |
| RPS27 | -7955 |
| RPS10 | -7813 |
| RPS14 | -7696 |
| RPS26 | -6894 |
| EIF3K | -6837 |
| RPS15 | -6628 |
| RPS8 | -6576 |
| EIF3G | -6552 |
| RPS3A | -6470 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227.0 |
| RPS21 | -10161.0 |
| RPS25 | -9987.0 |
| RPS27L | -9625.0 |
| RPS23 | -9619.0 |
| RPS2 | -9318.0 |
| RPS16 | -8804.0 |
| RPS28 | -8415.0 |
| RPS18 | -8283.0 |
| RPS19 | -8195.0 |
| EIF2S2 | -8003.0 |
| RPS27 | -7955.0 |
| RPS10 | -7813.0 |
| RPS14 | -7696.0 |
| RPS26 | -6894.0 |
| EIF3K | -6837.0 |
| RPS15 | -6628.0 |
| RPS8 | -6576.0 |
| EIF3G | -6552.0 |
| RPS3A | -6470.0 |
| EIF3J | -6294.0 |
| EIF3I | -5845.0 |
| FAU | -5597.0 |
| EIF4EBP1 | -5218.0 |
| RPS12 | -5167.0 |
| EIF3C | -5092.0 |
| EIF4E | -5005.0 |
| EIF3B | -4720.0 |
| EIF4A2 | -4629.0 |
| RPS20 | -4527.0 |
| EIF2S1 | -4046.0 |
| RPSA | -3980.0 |
| RPS5 | -3960.0 |
| RPS29 | -3270.0 |
| EIF4B | -3180.0 |
| RPS13 | -2416.0 |
| RPS6 | -2305.0 |
| RPS7 | -2277.0 |
| RPS11 | -1912.0 |
| RPS9 | -1389.0 |
| RPS17 | 0.5 |
| EIF3D | 1054.0 |
| EIF3F | 1102.0 |
| RPS3 | 1211.0 |
| EIF3L | 2402.0 |
| RPS15A | 2520.0 |
| EIF4A1 | 2690.0 |
| EIF4H | 3415.0 |
| RPS24 | 4526.0 |
| EIF3A | 5614.0 |
| EIF3E | 7984.0 |
| EIF3M | 8158.0 |
| EIF4G1 | 10468.0 |
| PABPC1 | 11193.0 |
| EIF3H | 13890.0 |
Mitochondrial translation
| 743 | |
|---|---|
| set | Mitochondrial translation |
| setSize | 93 |
| pANOVA | 1.27e-13 |
| s.dist | -0.444 |
| p.adjustANOVA | 5.17e-12 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| MRPL41 | -10260 |
| MRPL17 | -10157 |
| MRPL54 | -10079 |
| MRPL36 | -10054 |
| MRPS12 | -9957 |
| MRPL50 | -9841 |
| MTRF1L | -9817 |
| MRPS11 | -9745 |
| MRPL46 | -9737 |
| MTIF3 | -9383 |
| MRPL39 | -9323 |
| MRPL57 | -9163 |
| MRPL51 | -9126 |
| MRPS26 | -9012 |
| MRPS18B | -8816 |
| MRPS2 | -8592 |
| MRPL2 | -8528 |
| MRPL18 | -8525 |
| MRPS18C | -8310 |
| MRPL32 | -8179 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| MRPL41 | -10260.0 |
| MRPL17 | -10157.0 |
| MRPL54 | -10079.0 |
| MRPL36 | -10054.0 |
| MRPS12 | -9957.0 |
| MRPL50 | -9841.0 |
| MTRF1L | -9817.0 |
| MRPS11 | -9745.0 |
| MRPL46 | -9737.0 |
| MTIF3 | -9383.0 |
| MRPL39 | -9323.0 |
| MRPL57 | -9163.0 |
| MRPL51 | -9126.0 |
| MRPS26 | -9012.0 |
| MRPS18B | -8816.0 |
| MRPS2 | -8592.0 |
| MRPL2 | -8528.0 |
| MRPL18 | -8525.0 |
| MRPS18C | -8310.0 |
| MRPL32 | -8179.0 |
| AURKAIP1 | -8029.0 |
| MRPS36 | -7925.0 |
| MRPL55 | -7783.0 |
| MRPS34 | -7774.0 |
| MRPS30 | -7665.0 |
| MRPL47 | -7608.0 |
| OXA1L | -7581.0 |
| MRPS7 | -7385.0 |
| MRPL24 | -7055.0 |
| MRPS15 | -6964.0 |
| CHCHD1 | -6957.0 |
| MRPS16 | -6918.0 |
| MRPL12 | -6707.0 |
| MRPL53 | -6602.0 |
| MRPL43 | -6419.0 |
| MRPL30 | -6418.0 |
| GFM2 | -6263.0 |
| MRPL10 | -6147.0 |
| MRPL37 | -5856.0 |
| GADD45GIP1 | -5648.0 |
| MRPS17 | -5644.0 |
| MRPL44 | -5586.0 |
| MRPL21 | -5475.0 |
| MRPS24 | -5418.0 |
| MRPL27 | -5003.0 |
| MRPL34 | -4662.0 |
| TUFM | -4601.0 |
| MRPS31 | -4339.0 |
| MRPL40 | -4158.0 |
| MRPS23 | -4000.0 |
| MRPS33 | -3741.0 |
| MRPS35 | -3732.0 |
| MRPL14 | -3547.0 |
| MRPL49 | -3473.0 |
| MRPL4 | -3331.0 |
| MRPS10 | -3202.0 |
| MRPL42 | -3139.0 |
| MTIF2 | -3050.0 |
| MRPS5 | -2949.0 |
| MTFMT | -2849.0 |
| PTCD3 | -2052.0 |
| MRPL35 | -1780.0 |
| MRPL1 | -1713.0 |
| MRPL3 | -1693.0 |
| MRPL15 | 0.5 |
| MRPL33 | 1057.0 |
| ERAL1 | 1112.0 |
| MRPL52 | 1209.0 |
| MRPL20 | 1379.0 |
| DAP3 | 1678.0 |
| MRPL38 | 2518.0 |
| MRPS21 | 2627.0 |
| MRPL13 | 2725.0 |
| MRPS22 | 2752.0 |
| GFM1 | 2897.0 |
| MRPL28 | 3316.0 |
| MRPS18A | 3348.0 |
| MRPL9 | 3445.0 |
| MRPS25 | 4177.0 |
| MRPS14 | 4187.0 |
| MRPL11 | 4570.0 |
| MRPS9 | 4784.0 |
| MRPL19 | 4973.0 |
| MRPL23 | 5021.0 |
| MRPL16 | 5442.0 |
| MRRF | 5837.0 |
| TSFM | 6349.0 |
| MRPS28 | 7840.0 |
| MRPS6 | 8050.0 |
| MRPL48 | 8508.0 |
| MRPL45 | 9812.0 |
| MRPL22 | 9861.0 |
| MRPS27 | 11908.0 |
NRIF signals cell death from the nucleus
| 786 | |
|---|---|
| set | NRIF signals cell death from the nucleus |
| setSize | 16 |
| pANOVA | 0.00211 |
| s.dist | -0.444 |
| p.adjustANOVA | 0.0111 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| PSENEN | -10116 |
| NGFR | -9690 |
| APH1A | -8488 |
| UBC | -8113 |
| TRAF6 | -7019 |
| ITGB3BP | -6920 |
| APH1B | -6353 |
| SQSTM1 | -5082 |
| UBB | -4405 |
| PSEN2 | -2194 |
| NCSTN | -1564 |
| UBA52 | 4002 |
| PSEN1 | 7932 |
| NGF | 8086 |
| MAPK8 | 11082 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| RPS27A | -10227 |
| PSENEN | -10116 |
| NGFR | -9690 |
| APH1A | -8488 |
| UBC | -8113 |
| TRAF6 | -7019 |
| ITGB3BP | -6920 |
| APH1B | -6353 |
| SQSTM1 | -5082 |
| UBB | -4405 |
| PSEN2 | -2194 |
| NCSTN | -1564 |
| UBA52 | 4002 |
| PSEN1 | 7932 |
| NGF | 8086 |
| MAPK8 | 11082 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] grid stats4 parallel stats graphics grDevices utils
## [8] datasets methods base
##
## other attached packages:
## [1] pkgload_1.2.4
## [2] GGally_2.1.2
## [3] ggplot2_3.3.6
## [4] gtools_3.9.2
## [5] tibble_3.1.7
## [6] echarts4r_0.4.3
## [7] ENmix_1.32.0
## [8] doParallel_1.0.17
## [9] qqman_0.1.8
## [10] RCircos_1.2.2
## [11] beeswarm_0.4.0
## [12] forestplot_2.0.1
## [13] checkmate_2.1.0
## [14] magrittr_2.0.3
## [15] reshape2_1.4.4
## [16] gplots_3.1.3
## [17] GEOquery_2.64.2
## [18] RColorBrewer_1.1-3
## [19] IlluminaHumanMethylation450kmanifest_0.4.0
## [20] topconfects_1.12.0
## [21] DMRcatedata_2.14.0
## [22] ExperimentHub_2.4.0
## [23] AnnotationHub_3.4.0
## [24] BiocFileCache_2.4.0
## [25] dbplyr_2.1.1
## [26] DMRcate_2.10.0
## [27] limma_3.52.1
## [28] missMethyl_1.30.0
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1
## [31] minfi_1.42.0
## [32] bumphunter_1.38.0
## [33] locfit_1.5-9.5
## [34] iterators_1.0.14
## [35] foreach_1.5.2
## [36] Biostrings_2.64.0
## [37] XVector_0.36.0
## [38] SummarizedExperiment_1.26.1
## [39] Biobase_2.56.0
## [40] MatrixGenerics_1.8.0
## [41] matrixStats_0.62.0
## [42] GenomicRanges_1.48.0
## [43] GenomeInfoDb_1.32.2
## [44] IRanges_2.30.0
## [45] S4Vectors_0.34.0
## [46] BiocGenerics_0.42.0
## [47] R.utils_2.11.0
## [48] R.oo_1.24.0
## [49] R.methodsS3_1.8.1
## [50] plyr_1.8.7
## [51] tictoc_1.0.1
## [52] mitch_1.8.0
## [53] eulerr_6.1.1
## [54] kableExtra_1.3.4
## [55] dplyr_1.0.9
##
## loaded via a namespace (and not attached):
## [1] rappdirs_0.3.3 rtracklayer_1.56.0
## [3] tidyr_1.2.0 bit64_4.0.5
## [5] knitr_1.39 DelayedArray_0.22.0
## [7] data.table_1.14.2 rpart_4.1.16
## [9] KEGGREST_1.36.0 RCurl_1.98-1.6
## [11] AnnotationFilter_1.20.0 generics_0.1.2
## [13] GenomicFeatures_1.48.1 preprocessCore_1.58.0
## [15] RSQLite_2.2.14 bit_4.0.4
## [17] tzdb_0.3.0 webshot_0.5.3
## [19] xml2_1.3.3 httpuv_1.6.5
## [21] assertthat_0.2.1 xfun_0.31
## [23] hms_1.1.1 jquerylib_0.1.4
## [25] evaluate_0.15 promises_1.2.0.1
## [27] fansi_1.0.3 restfulr_0.0.13
## [29] scrime_1.3.5 progress_1.2.2
## [31] caTools_1.18.2 readxl_1.4.0
## [33] DBI_1.1.2 geneplotter_1.74.0
## [35] htmlwidgets_1.5.4 reshape_0.8.9
## [37] purrr_0.3.4 ellipsis_0.3.2
## [39] backports_1.4.1 permute_0.9-7
## [41] calibrate_1.7.7 annotate_1.74.0
## [43] biomaRt_2.52.0 sparseMatrixStats_1.8.0
## [45] vctrs_0.4.1 ensembldb_2.20.1
## [47] withr_2.5.0 cachem_1.0.6
## [49] Gviz_1.40.1 BSgenome_1.64.0
## [51] GenomicAlignments_1.32.0 prettyunits_1.1.1
## [53] mclust_5.4.9 svglite_2.1.0
## [55] cluster_2.1.3 RPMM_1.25
## [57] lazyeval_0.2.2 crayon_1.5.1
## [59] genefilter_1.78.0 edgeR_3.38.1
## [61] pkgconfig_2.0.3 nlme_3.1-157
## [63] ProtGenerics_1.28.0 nnet_7.3-17
## [65] rlang_1.0.2 lifecycle_1.0.1
## [67] filelock_1.0.2 dichromat_2.0-0.1
## [69] rprojroot_2.0.3 cellranger_1.1.0
## [71] rngtools_1.5.2 base64_2.0
## [73] Matrix_1.4-1 Rhdf5lib_1.18.2
## [75] base64enc_0.1-3 png_0.1-7
## [77] viridisLite_0.4.0 rjson_0.2.21
## [79] bitops_1.0-7 KernSmooth_2.23-20
## [81] rhdf5filters_1.8.0 blob_1.2.3
## [83] DelayedMatrixStats_1.18.0 doRNG_1.8.2
## [85] stringr_1.4.0 nor1mix_1.3-0
## [87] readr_2.1.2 jpeg_0.1-9
## [89] scales_1.2.0 memoise_2.0.1
## [91] zlibbioc_1.42.0 compiler_4.2.0
## [93] BiocIO_1.6.0 illuminaio_0.38.0
## [95] Rsamtools_2.12.0 cli_3.3.0
## [97] DSS_2.44.0 htmlTable_2.4.0
## [99] Formula_1.2-4 MASS_7.3-57
## [101] tidyselect_1.1.2 stringi_1.7.6
## [103] highr_0.9 yaml_2.3.5
## [105] askpass_1.1 latticeExtra_0.6-29
## [107] sass_0.4.1 VariantAnnotation_1.42.1
## [109] tools_4.2.0 rstudioapi_0.13
## [111] foreign_0.8-82 bsseq_1.32.0
## [113] gridExtra_2.3 digest_0.6.29
## [115] BiocManager_1.30.17 shiny_1.7.1
## [117] quadprog_1.5-8 Rcpp_1.0.8.3
## [119] siggenes_1.70.0 BiocVersion_3.15.2
## [121] later_1.3.0 org.Hs.eg.db_3.15.0
## [123] httr_1.4.3 AnnotationDbi_1.58.0
## [125] biovizBase_1.44.0 colorspace_2.0-3
## [127] brio_1.1.3 rvest_1.0.2
## [129] XML_3.99-0.9 splines_4.2.0
## [131] statmod_1.4.36 multtest_2.52.0
## [133] systemfonts_1.0.4 xtable_1.8-4
## [135] jsonlite_1.8.0 dynamicTreeCut_1.63-1
## [137] testthat_3.1.4 R6_2.5.1
## [139] Hmisc_4.7-0 pillar_1.7.0
## [141] htmltools_0.5.2 mime_0.12
## [143] glue_1.6.2 fastmap_1.1.0
## [145] BiocParallel_1.30.2 interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1 codetools_0.2-18
## [149] utf8_1.2.2 bslib_0.3.1
## [151] lattice_0.20-45 curl_4.3.2
## [153] openssl_2.0.1 survival_3.3-1
## [155] rmarkdown_2.14 desc_1.4.1
## [157] munsell_0.5.0 rhdf5_2.40.0
## [159] GenomeInfoDbData_1.2.8 HDF5Array_1.24.0
## [161] impute_1.70.0 gtable_0.3.0END of report