Mitch Report

date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##           metric
## HOXC4 -20.795272
## SEPT9  -9.353202
## PAX6  -13.889120
## BRD2  -12.030452
## HOXC5 -15.303482
## GNL1  -10.941771

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2546
num_genes_in_profile	26148
duplicated_genes_present	0
num_profile_genes_in_sets	10252
num_profile_genes_not_in_sets	15896

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1018
num_genesets_included	1528

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
RUNX3 regulates p14-ARF	10	2.58e-04	-0.667	1.04e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	7.97e-04	-0.612	2.80e-03
Digestion of dietary carbohydrate	10	7.98e-04	0.612	2.80e-03
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	1.00e-04	-0.600	4.51e-04
SUMOylation of immune response proteins	10	1.36e-03	-0.585	4.51e-03
Activation of the TFAP2 (AP-2) family of transcription factors	11	8.45e-04	-0.581	2.93e-03
Eukaryotic Translation Elongation	88	4.99e-21	-0.579	2.18e-19
Viral mRNA Translation	84	8.07e-20	-0.574	3.01e-18
Peptide chain elongation	84	8.92e-20	-0.574	3.25e-18
Condensation of Prometaphase Chromosomes	11	1.05e-03	-0.570	3.58e-03
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	6.43e-04	-0.569	2.34e-03
Beta defensins	32	2.54e-08	0.569	2.38e-07
Constitutive Signaling by Overexpressed ERBB2	10	1.87e-03	-0.568	5.95e-03
SRP-dependent cotranslational protein targeting to membrane	105	1.70e-23	-0.563	1.00e-21
Eukaryotic Translation Termination	87	1.24e-19	-0.562	4.41e-18
Formation of a pool of free 40S subunits	95	2.40e-20	-0.548	9.39e-19
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	2.89e-20	-0.547	1.11e-18
Defensins	40	2.56e-09	0.544	3.11e-08
GTP hydrolysis and joining of the 60S ribosomal subunit	105	7.61e-22	-0.542	3.63e-20
ERKs are inactivated	13	7.36e-04	-0.541	2.63e-03
Cap-dependent Translation Initiation	112	1.14e-22	-0.535	6.03e-21
Eukaryotic Translation Initiation	112	1.14e-22	-0.535	6.03e-21
Expression and translocation of olfactory receptors	365	1.75e-69	0.535	2.68e-66
L13a-mediated translational silencing of Ceruloplasmin expression	104	4.59e-21	-0.534	2.06e-19
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	3.01e-18	-0.534	9.03e-17
Mitochondrial translation termination	87	7.37e-18	-0.533	2.11e-16
Selenocysteine synthesis	87	7.47e-18	-0.533	2.11e-16
Mitochondrial translation	93	1.12e-18	-0.529	3.57e-17
Mitochondrial translation elongation	87	2.59e-17	-0.524	7.20e-16
Mitochondrial translation initiation	87	2.94e-17	-0.523	8.02e-16
Olfactory Signaling Pathway	372	3.10e-67	0.521	1.58e-64
Folding of actin by CCT/TriC	10	4.40e-03	-0.520	1.26e-02
Crosslinking of collagen fibrils	10	4.45e-03	-0.519	1.27e-02
Translation	263	1.77e-47	-0.517	3.00e-45
NGF-stimulated transcription	39	3.78e-08	-0.509	3.42e-07
SCF(Skp2)-mediated degradation of p27/p21	58	2.07e-11	-0.508	3.60e-10
SUMOylation of transcription factors	20	8.92e-05	-0.506	4.12e-04
Purine ribonucleoside monophosphate biosynthesis	11	3.81e-03	-0.504	1.11e-02
Interaction With Cumulus Cells And The Zona Pellucida	11	4.24e-03	0.498	1.22e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	108	5.33e-19	-0.495	1.77e-17
Nonsense-Mediated Decay (NMD)	108	5.33e-19	-0.495	1.77e-17
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	6.70e-03	-0.495	1.78e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	4.66e-03	-0.493	1.31e-02
Pexophagy	11	4.83e-03	-0.491	1.36e-02
FOXO-mediated transcription of cell cycle genes	16	7.41e-04	-0.487	2.64e-03
Interleukin-2 signaling	11	5.16e-03	-0.487	1.43e-02
Inhibition of DNA recombination at telomere	20	1.66e-04	-0.486	7.04e-04
Influenza Viral RNA Transcription and Replication	129	1.97e-21	-0.484	9.13e-20
Regulation of expression of SLITs and ROBOs	159	6.09e-26	-0.483	4.65e-24
Formation of the ternary complex, and subsequently, the 43S complex	47	1.29e-08	-0.479	1.28e-07

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
RUNX3 regulates p14-ARF	10	2.58e-04	-0.667000	1.04e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	7.97e-04	-0.612000	2.80e-03
Digestion of dietary carbohydrate	10	7.98e-04	0.612000	2.80e-03
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	1.00e-04	-0.600000	4.51e-04
SUMOylation of immune response proteins	10	1.36e-03	-0.585000	4.51e-03
Activation of the TFAP2 (AP-2) family of transcription factors	11	8.45e-04	-0.581000	2.93e-03
Eukaryotic Translation Elongation	88	4.99e-21	-0.579000	2.18e-19
Viral mRNA Translation	84	8.07e-20	-0.574000	3.01e-18
Peptide chain elongation	84	8.92e-20	-0.574000	3.25e-18
Condensation of Prometaphase Chromosomes	11	1.05e-03	-0.570000	3.58e-03
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	6.43e-04	-0.569000	2.34e-03
Beta defensins	32	2.54e-08	0.569000	2.38e-07
Constitutive Signaling by Overexpressed ERBB2	10	1.87e-03	-0.568000	5.95e-03
SRP-dependent cotranslational protein targeting to membrane	105	1.70e-23	-0.563000	1.00e-21
Eukaryotic Translation Termination	87	1.24e-19	-0.562000	4.41e-18
Formation of a pool of free 40S subunits	95	2.40e-20	-0.548000	9.39e-19
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	2.89e-20	-0.547000	1.11e-18
Defensins	40	2.56e-09	0.544000	3.11e-08
GTP hydrolysis and joining of the 60S ribosomal subunit	105	7.61e-22	-0.542000	3.63e-20
ERKs are inactivated	13	7.36e-04	-0.541000	2.63e-03
Cap-dependent Translation Initiation	112	1.14e-22	-0.535000	6.03e-21
Eukaryotic Translation Initiation	112	1.14e-22	-0.535000	6.03e-21
Expression and translocation of olfactory receptors	365	1.75e-69	0.535000	2.68e-66
L13a-mediated translational silencing of Ceruloplasmin expression	104	4.59e-21	-0.534000	2.06e-19
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	3.01e-18	-0.534000	9.03e-17
Mitochondrial translation termination	87	7.37e-18	-0.533000	2.11e-16
Selenocysteine synthesis	87	7.47e-18	-0.533000	2.11e-16
Mitochondrial translation	93	1.12e-18	-0.529000	3.57e-17
Mitochondrial translation elongation	87	2.59e-17	-0.524000	7.20e-16
Mitochondrial translation initiation	87	2.94e-17	-0.523000	8.02e-16
Olfactory Signaling Pathway	372	3.10e-67	0.521000	1.58e-64
Folding of actin by CCT/TriC	10	4.40e-03	-0.520000	1.26e-02
Crosslinking of collagen fibrils	10	4.45e-03	-0.519000	1.27e-02
Translation	263	1.77e-47	-0.517000	3.00e-45
NGF-stimulated transcription	39	3.78e-08	-0.509000	3.42e-07
SCF(Skp2)-mediated degradation of p27/p21	58	2.07e-11	-0.508000	3.60e-10
SUMOylation of transcription factors	20	8.92e-05	-0.506000	4.12e-04
Purine ribonucleoside monophosphate biosynthesis	11	3.81e-03	-0.504000	1.11e-02
Interaction With Cumulus Cells And The Zona Pellucida	11	4.24e-03	0.498000	1.22e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	108	5.33e-19	-0.495000	1.77e-17
Nonsense-Mediated Decay (NMD)	108	5.33e-19	-0.495000	1.77e-17
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	6.70e-03	-0.495000	1.78e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	4.66e-03	-0.493000	1.31e-02
Pexophagy	11	4.83e-03	-0.491000	1.36e-02
FOXO-mediated transcription of cell cycle genes	16	7.41e-04	-0.487000	2.64e-03
Interleukin-2 signaling	11	5.16e-03	-0.487000	1.43e-02
Inhibition of DNA recombination at telomere	20	1.66e-04	-0.486000	7.04e-04
Influenza Viral RNA Transcription and Replication	129	1.97e-21	-0.484000	9.13e-20
Regulation of expression of SLITs and ROBOs	159	6.09e-26	-0.483000	4.65e-24
Formation of the ternary complex, and subsequently, the 43S complex	47	1.29e-08	-0.479000	1.28e-07
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	4.57e-09	-0.479000	5.06e-08
Nuclear Events (kinase and transcription factor activation)	60	1.43e-10	-0.478000	2.18e-09
Major pathway of rRNA processing in the nucleolus and cytosol	171	3.88e-27	-0.477000	3.29e-25
Unwinding of DNA	12	4.44e-03	-0.474000	1.27e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	1.48e-03	0.474000	4.83e-03
Negative regulation of NOTCH4 signaling	52	4.26e-09	-0.470000	4.76e-08
CASP8 activity is inhibited	11	7.12e-03	-0.468000	1.86e-02
Dimerization of procaspase-8	11	7.12e-03	-0.468000	1.86e-02
Regulation by c-FLIP	11	7.12e-03	-0.468000	1.86e-02
Initiation of Nuclear Envelope (NE) Reformation	18	5.94e-04	-0.467000	2.18e-03
Selenoamino acid metabolism	103	2.39e-16	-0.467000	6.31e-15
Ribosomal scanning and start codon recognition	54	2.84e-09	-0.467000	3.39e-08
FGFR2 alternative splicing	26	3.98e-05	-0.465000	1.98e-04
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	9.36e-04	-0.463000	3.20e-03
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	9.36e-04	-0.463000	3.20e-03
rRNA processing in the nucleus and cytosol	180	6.58e-27	-0.463000	5.29e-25
Erythropoietin activates RAS	14	2.76e-03	-0.462000	8.37e-03
Influenza Infection	148	3.51e-22	-0.460000	1.73e-20
Processing of Intronless Pre-mRNAs	19	5.11e-04	-0.460000	1.93e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	55	3.75e-09	-0.459000	4.21e-08
Translation initiation complex formation	54	6.15e-09	-0.457000	6.52e-08
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	21	3.01e-04	-0.455000	1.19e-03
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	1.30e-02	-0.454000	3.15e-02
Synthesis of glycosylphosphatidylinositol (GPI)	17	1.27e-03	-0.451000	4.23e-03
Digestion and absorption	26	6.73e-05	0.451000	3.18e-04
SCF-beta-TrCP mediated degradation of Emi1	53	1.38e-08	-0.450000	1.35e-07
Cyclin A:Cdk2-associated events at S phase entry	83	1.42e-12	-0.449000	3.14e-11
Negative epigenetic regulation of rRNA expression	45	1.86e-07	-0.449000	1.46e-06
B-WICH complex positively regulates rRNA expression	29	2.97e-05	-0.448000	1.54e-04
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	1.48e-06	0.445000	9.81e-06
NoRC negatively regulates rRNA expression	43	4.68e-07	-0.444000	3.39e-06
Ubiquitin-dependent degradation of Cyclin D	50	5.71e-08	-0.443000	4.98e-07
Cyclin E associated events during G1/S transition	81	5.05e-12	-0.443000	9.52e-11
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	2.35e-08	-0.443000	2.22e-07
rRNA processing	186	1.67e-25	-0.443000	1.22e-23
Autodegradation of Cdh1 by Cdh1:APC/C	62	1.66e-09	-0.442000	2.17e-08
RNA Polymerase III Transcription Termination	23	2.48e-04	-0.441000	9.99e-04
Signaling by NOTCH4	79	1.16e-11	-0.441000	2.06e-10
RNA Polymerase I Promoter Escape	28	5.39e-05	-0.441000	2.63e-04
TP53 Regulates Transcription of Cell Cycle Genes	49	9.58e-08	-0.440000	7.87e-07
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	8.02e-08	-0.438000	6.66e-07
p53-Independent DNA Damage Response	50	8.02e-08	-0.438000	6.66e-07
p53-Independent G1/S DNA damage checkpoint	50	8.02e-08	-0.438000	6.66e-07
Digestion	21	5.18e-04	0.437000	1.95e-03
ERK/MAPK targets	20	7.06e-04	-0.437000	2.53e-03
Autodegradation of the E3 ubiquitin ligase COP1	50	9.72e-08	-0.436000	7.94e-07
RNA Polymerase III Chain Elongation	18	1.41e-03	-0.435000	4.61e-03
RNA Polymerase I Transcription Termination	27	9.56e-05	-0.434000	4.38e-04
Antimicrobial peptides	82	1.11e-11	0.433000	2.00e-10
APC/C-mediated degradation of cell cycle proteins	86	3.62e-12	-0.433000	7.10e-11
Regulation of mitotic cell cycle	86	3.62e-12	-0.433000	7.10e-11
SARS-CoV-2 modulates host translation machinery	46	3.68e-07	-0.433000	2.69e-06
Processing of Capped Intronless Pre-mRNA	28	7.33e-05	-0.433000	3.44e-04
KSRP (KHSRP) binds and destabilizes mRNA	17	2.01e-03	-0.432000	6.36e-03
APC/C:Cdc20 mediated degradation of mitotic proteins	74	1.27e-10	-0.432000	1.98e-09
p53-Dependent G1 DNA Damage Response	64	2.48e-09	-0.431000	3.03e-08
p53-Dependent G1/S DNA damage checkpoint	64	2.48e-09	-0.431000	3.03e-08
The role of GTSE1 in G2/M progression after G2 checkpoint	58	1.43e-08	-0.430000	1.40e-07
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	1.19e-10	-0.430000	1.87e-09
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	2.92e-10	-0.429000	4.18e-09
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	4.19e-10	-0.428000	5.87e-09
Regulation of RUNX3 expression and activity	53	6.73e-08	-0.428000	5.71e-07
Cellular response to starvation	147	3.05e-19	-0.428000	1.06e-17
Metabolism of polyamines	55	4.08e-08	-0.427000	3.64e-07
G1/S DNA Damage Checkpoints	66	1.85e-09	-0.427000	2.36e-08
Asymmetric localization of PCP proteins	62	5.90e-09	-0.427000	6.31e-08
Intrinsic Pathway of Fibrin Clot Formation	21	7.35e-04	0.425000	2.63e-03
Regulation of ornithine decarboxylase (ODC)	49	2.53e-07	-0.425000	1.93e-06
Vpu mediated degradation of CD4	50	1.96e-07	-0.425000	1.52e-06
Positive epigenetic regulation of rRNA expression	43	1.41e-06	-0.425000	9.47e-06
Transcriptional regulation of granulopoiesis	31	4.72e-05	-0.422000	2.32e-04
RAF-independent MAPK1/3 activation	22	6.17e-04	-0.422000	2.26e-03
Regulation of APC/C activators between G1/S and early anaphase	79	9.26e-11	-0.421000	1.49e-09
Prefoldin mediated transfer of substrate to CCT/TriC	27	1.53e-04	-0.421000	6.56e-04
GLI3 is processed to GLI3R by the proteasome	58	3.23e-08	-0.419000	2.97e-07
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	7.49e-10	-0.419000	1.02e-08
NIK–>noncanonical NF-kB signaling	57	4.31e-08	-0.419000	3.83e-07
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	5.74e-07	-0.417000	4.10e-06
APC/C:Cdc20 mediated degradation of Securin	66	4.72e-09	-0.417000	5.13e-08
Response of EIF2AK1 (HRI) to heme deficiency	14	6.95e-03	-0.417000	1.83e-02
TICAM1, RIP1-mediated IKK complex recruitment	18	2.25e-03	-0.416000	7.07e-03
WNT ligand biogenesis and trafficking	25	3.21e-04	-0.416000	1.26e-03
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	1.85e-04	-0.415000	7.73e-04
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	1.76e-07	-0.414000	1.39e-06
Signaling by Activin	15	5.48e-03	-0.414000	1.49e-02
Defects in cobalamin (B12) metabolism	12	1.33e-02	-0.412000	3.22e-02
Mitochondrial iron-sulfur cluster biogenesis	12	1.34e-02	-0.412000	3.23e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	3.26e-03	-0.412000	9.59e-03
Dectin-1 mediated noncanonical NF-kB signaling	60	3.49e-08	-0.411000	3.19e-07
RIPK1-mediated regulated necrosis	27	2.15e-04	-0.411000	8.80e-04
Regulation of necroptotic cell death	27	2.15e-04	-0.411000	8.80e-04
DNA Damage/Telomere Stress Induced Senescence	28	1.67e-04	-0.411000	7.07e-04
Hh mutants are degraded by ERAD	54	1.92e-07	-0.409000	1.50e-06
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	1.82e-04	-0.408000	7.64e-04
CDK-mediated phosphorylation and removal of Cdc6	71	2.60e-09	-0.408000	3.13e-08
Degradation of cysteine and homocysteine	14	8.23e-03	-0.408000	2.11e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	1.09e-02	-0.407000	2.72e-02
mRNA decay by 5’ to 3’ exoribonuclease	15	6.28e-03	-0.407000	1.67e-02
Signaling by ROBO receptors	203	1.18e-23	-0.407000	7.23e-22
RIP-mediated NFkB activation via ZBP1	16	4.81e-03	-0.407000	1.35e-02
TP53 Regulates Transcription of Death Receptors and Ligands	12	1.47e-02	-0.407000	3.48e-02
Hh mutants abrogate ligand secretion	57	1.16e-07	-0.406000	9.39e-07
Defective Intrinsic Pathway for Apoptosis	25	4.51e-04	-0.405000	1.74e-03
Diseases of programmed cell death	41	7.23e-06	-0.405000	4.36e-05
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	95	9.62e-12	-0.404000	1.75e-10
Respiratory electron transport	90	3.50e-11	-0.404000	5.81e-10
Diseases associated with N-glycosylation of proteins	19	2.33e-03	-0.403000	7.26e-03
Regulation of Apoptosis	51	6.93e-07	-0.401000	4.90e-06
mRNA decay by 3’ to 5’ exoribonuclease	16	5.48e-03	-0.401000	1.49e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	14	9.37e-03	0.401000	2.37e-02
Diseases of hemostasis	14	9.37e-03	0.401000	2.37e-02
Activation of HOX genes during differentiation	61	6.01e-08	-0.401000	5.16e-07
Activation of anterior HOX genes in hindbrain development during early embryogenesis	61	6.01e-08	-0.401000	5.16e-07
Regulation of RAS by GAPs	66	1.88e-08	-0.400000	1.78e-07
Stabilization of p53	55	3.17e-07	-0.398000	2.37e-06
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	7.56e-03	-0.398000	1.96e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	32	9.65e-05	-0.398000	4.38e-04
Degradation of AXIN	53	5.44e-07	-0.398000	3.90e-06
Vif-mediated degradation of APOBEC3G	50	1.14e-06	-0.398000	7.73e-06
Apoptotic factor-mediated response	17	4.58e-03	-0.397000	1.30e-02
FGFRL1 modulation of FGFR1 signaling	13	1.32e-02	-0.397000	3.19e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs	68	1.52e-08	-0.397000	1.47e-07
Diseases of mitotic cell cycle	37	3.06e-05	-0.396000	1.58e-04
Formation of TC-NER Pre-Incision Complex	51	1.02e-06	-0.395000	7.01e-06
Metabolism of cofactors	19	2.96e-03	-0.394000	8.91e-03
Degradation of GLI2 by the proteasome	58	2.13e-07	-0.394000	1.64e-06
Cyclin A/B1/B2 associated events during G2/M transition	24	8.54e-04	-0.393000	2.95e-03
mRNA Splicing - Minor Pathway	53	7.41e-07	-0.393000	5.21e-06
HDR through MMEJ (alt-NHEJ)	11	2.42e-02	-0.392000	5.31e-02
Polo-like kinase mediated events	16	6.59e-03	-0.392000	1.75e-02
G1/S Transition	126	2.88e-14	-0.392000	6.88e-13
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	2.45e-02	-0.392000	5.35e-02
Signaling by FGFR2 IIIa TM	19	3.23e-03	-0.390000	9.55e-03
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	4.21e-03	-0.389000	1.22e-02
Cellular response to hypoxia	71	1.36e-08	-0.389000	1.34e-07
Degradation of GLI1 by the proteasome	58	3.01e-07	-0.389000	2.26e-06
Assembly of the pre-replicative complex	82	1.19e-09	-0.388000	1.57e-08
Signalling to RAS	20	2.64e-03	-0.388000	8.05e-03
Regulation of mRNA stability by proteins that bind AU-rich elements	87	4.23e-10	-0.387000	5.88e-09
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	7.34e-03	-0.387000	1.91e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	5.88e-05	-0.387000	2.84e-04
NRIF signals cell death from the nucleus	16	7.40e-03	-0.387000	1.92e-02
Keratinization	214	1.70e-22	0.386000	8.65e-21
Glucocorticoid biosynthesis	10	3.47e-02	0.386000	7.10e-02
Activation of the phototransduction cascade	11	2.68e-02	0.385000	5.77e-02
Mitotic G1 phase and G1/S transition	144	1.33e-15	-0.385000	3.38e-14
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	16	7.64e-03	-0.385000	1.98e-02
Pausing and recovery of Tat-mediated HIV elongation	27	5.32e-04	-0.385000	1.99e-03
Tat-mediated HIV elongation arrest and recovery	27	5.32e-04	-0.385000	1.99e-03
Orc1 removal from chromatin	69	3.16e-08	-0.385000	2.93e-07
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	62	1.57e-07	-0.385000	1.25e-06
mRNA Capping	28	4.24e-04	-0.385000	1.64e-03
Cross-presentation of soluble exogenous antigens (endosomes)	48	4.18e-06	-0.384000	2.63e-05
HDACs deacetylate histones	29	3.54e-04	-0.383000	1.38e-03
RNA Polymerase I Transcription	47	5.49e-06	-0.383000	3.40e-05
SLBP independent Processing of Histone Pre-mRNAs	10	3.60e-02	-0.383000	7.29e-02
Regulation of PTEN gene transcription	59	3.64e-07	-0.383000	2.68e-06
Transcriptional regulation by RUNX3	93	1.75e-10	-0.383000	2.58e-09
Interleukin-15 signaling	13	1.73e-02	-0.381000	4.01e-02
Complex I biogenesis	49	3.87e-06	-0.381000	2.44e-05
Hormone ligand-binding receptors	13	1.74e-02	0.381000	4.01e-02
Nuclear events mediated by NFE2L2	76	9.36e-09	-0.381000	9.59e-08
Synthesis of PE	12	2.24e-02	-0.381000	4.96e-02
Degradation of beta-catenin by the destruction complex	81	3.12e-09	-0.381000	3.66e-08
mRNA Splicing	183	7.15e-19	-0.380000	2.32e-17
tRNA processing in the nucleus	55	1.11e-06	-0.379000	7.58e-06
mRNA Splicing - Major Pathway	173	7.12e-18	-0.379000	2.09e-16
UCH proteinases	81	3.75e-09	-0.379000	4.21e-08
Defective pyroptosis	11	2.97e-02	-0.379000	6.25e-02
Degradation of DVL	55	1.19e-06	-0.378000	8.06e-06
TICAM1-dependent activation of IRF3/IRF7	12	2.32e-02	-0.378000	5.11e-02
Processing and activation of SUMO	10	3.83e-02	-0.378000	7.70e-02
RNA Pol II CTD phosphorylation and interaction with CE	26	8.46e-04	-0.378000	2.93e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	8.46e-04	-0.378000	2.93e-03
Sensory Perception	576	1.25e-54	0.378000	2.39e-52
RNA Polymerase I Promoter Clearance	46	9.44e-06	-0.377000	5.59e-05
FOXO-mediated transcription of cell death genes	15	1.18e-02	-0.375000	2.90e-02
Mitochondrial protein import	54	1.84e-06	-0.375000	1.20e-05
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	2.41e-04	-0.375000	9.75e-04
Switching of origins to a post-replicative state	90	8.04e-10	-0.374000	1.09e-08
Regulation of RUNX2 expression and activity	71	4.80e-08	-0.374000	4.24e-07
Regulation of TP53 Activity through Phosphorylation	88	1.24e-09	-0.374000	1.64e-08
Metabolism of RNA	638	8.31e-59	-0.373000	2.12e-56
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	34	1.69e-04	-0.373000	7.12e-04
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	1.63e-03	0.371000	5.28e-03
Aspirin ADME	44	2.03e-05	0.371000	1.13e-04
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	5.19e-03	-0.370000	1.43e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	2.65e-03	-0.370000	8.05e-03
STAT5 activation downstream of FLT3 ITD mutants	10	4.29e-02	-0.370000	8.39e-02
p38MAPK events	13	2.12e-02	-0.369000	4.77e-02
Regulation of gene expression by Hypoxia-inducible Factor	11	3.40e-02	-0.369000	6.97e-02
RMTs methylate histone arginines	29	5.81e-04	-0.369000	2.14e-03
HIV elongation arrest and recovery	29	5.82e-04	-0.369000	2.14e-03
Pausing and recovery of HIV elongation	29	5.82e-04	-0.369000	2.14e-03
HIV Transcription Initiation	43	2.83e-05	-0.369000	1.49e-04
RNA Polymerase II HIV Promoter Escape	43	2.83e-05	-0.369000	1.49e-04
RNA Polymerase II Promoter Escape	43	2.83e-05	-0.369000	1.49e-04
RNA Polymerase II Transcription Initiation	43	2.83e-05	-0.369000	1.49e-04
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	2.83e-05	-0.369000	1.49e-04
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	2.83e-05	-0.369000	1.49e-04
DNA Replication Pre-Initiation	97	3.33e-10	-0.369000	4.71e-09
Base-Excision Repair, AP Site Formation	18	6.77e-03	-0.369000	1.79e-02
G0 and Early G1	27	9.20e-04	-0.368000	3.16e-03
Epigenetic regulation of gene expression	83	6.85e-09	-0.368000	7.17e-08
Inactivation of APC/C via direct inhibition of the APC/C complex	21	3.77e-03	-0.365000	1.10e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	3.77e-03	-0.365000	1.10e-02
Cleavage of the damaged purine	11	3.60e-02	-0.365000	7.29e-02
Depurination	11	3.60e-02	-0.365000	7.29e-02
Recognition and association of DNA glycosylase with site containing an affected purine	11	3.60e-02	-0.365000	7.29e-02
MAPK targets/ Nuclear events mediated by MAP kinases	29	6.69e-04	-0.365000	2.41e-03
Defective CFTR causes cystic fibrosis	59	1.24e-06	-0.365000	8.35e-06
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.81e-02	-0.365000	4.15e-02
Separation of Sister Chromatids	161	1.35e-15	-0.364000	3.39e-14
Mitochondrial tRNA aminoacylation	18	7.53e-03	-0.364000	1.95e-02
Metallothioneins bind metals	11	3.67e-02	-0.364000	7.41e-02
TP53 Regulates Transcription of DNA Repair Genes	57	2.07e-06	-0.363000	1.35e-05
RUNX2 regulates osteoblast differentiation	22	3.20e-03	-0.363000	9.49e-03
Sulfur amino acid metabolism	27	1.09e-03	-0.363000	3.72e-03
ZBP1(DAI) mediated induction of type I IFNs	20	5.00e-03	-0.362000	1.40e-02
Purine salvage	12	2.99e-02	-0.362000	6.29e-02
Estrogen-dependent gene expression	91	2.45e-09	-0.361000	3.03e-08
PCP/CE pathway	90	3.27e-09	-0.361000	3.82e-08
Heme degradation	16	1.28e-02	0.360000	3.10e-02
Hedgehog ligand biogenesis	63	8.44e-07	-0.359000	5.86e-06
APC-Cdc20 mediated degradation of Nek2A	26	1.58e-03	-0.358000	5.12e-03
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	5.66e-03	-0.357000	1.53e-02
G2/M Checkpoints	129	2.32e-12	-0.357000	4.92e-11
Processing of Capped Intron-Containing Pre-mRNA	231	8.18e-21	-0.357000	3.47e-19
G1/S-Specific Transcription	28	1.09e-03	-0.356000	3.72e-03
Methylation	14	2.10e-02	-0.356000	4.72e-02
SHC-mediated cascade:FGFR1	21	4.72e-03	-0.356000	1.33e-02
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	12	3.30e-02	-0.355000	6.82e-02
Disorders of Developmental Biology	11	4.14e-02	-0.355000	8.14e-02
Disorders of Nervous System Development	11	4.14e-02	-0.355000	8.14e-02
Loss of function of MECP2 in Rett syndrome	11	4.14e-02	-0.355000	8.14e-02
Pervasive developmental disorders	11	4.14e-02	-0.355000	8.14e-02
Cyclin D associated events in G1	46	3.13e-05	-0.355000	1.60e-04
G1 Phase	46	3.13e-05	-0.355000	1.60e-04
Association of TriC/CCT with target proteins during biosynthesis	38	1.57e-04	-0.354000	6.71e-04
RNA Polymerase I Transcription Initiation	42	7.35e-05	-0.353000	3.44e-04
DNA Damage Recognition in GG-NER	36	2.49e-04	-0.353000	1.00e-03
Signaling by NTRK1 (TRKA)	114	7.59e-11	-0.352000	1.23e-09
Transcriptional regulation of pluripotent stem cells	30	8.31e-04	-0.352000	2.90e-03
Heme biosynthesis	13	2.79e-02	-0.352000	5.97e-02
Signaling by Leptin	11	4.32e-02	-0.352000	8.43e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	1.21e-02	-0.351000	2.96e-02
PINK1-PRKN Mediated Mitophagy	21	5.33e-03	-0.351000	1.46e-02
Early Phase of HIV Life Cycle	14	2.29e-02	-0.351000	5.05e-02
Senescence-Associated Secretory Phenotype (SASP)	53	1.01e-05	-0.350000	5.94e-05
Calnexin/calreticulin cycle	25	2.45e-03	-0.350000	7.53e-03
Other interleukin signaling	24	3.04e-03	-0.349000	9.08e-03
Beta-catenin phosphorylation cascade	16	1.55e-02	-0.349000	3.66e-02
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	1.10e-04	0.349000	4.94e-04
Negative regulation of MAPK pathway	41	1.12e-04	-0.348000	5.00e-04
Formation of HIV-1 elongation complex containing HIV-1 Tat	38	2.11e-04	-0.347000	8.70e-04
HIV Transcription Elongation	38	2.11e-04	-0.347000	8.70e-04
Tat-mediated elongation of the HIV-1 transcript	38	2.11e-04	-0.347000	8.70e-04
Abortive elongation of HIV-1 transcript in the absence of Tat	23	3.98e-03	-0.347000	1.15e-02
DNA Replication	125	2.35e-11	-0.346000	4.04e-10
XBP1(S) activates chaperone genes	48	3.45e-05	-0.345000	1.76e-04
AKT phosphorylates targets in the cytosol	14	2.54e-02	-0.345000	5.51e-02
Viral Messenger RNA Synthesis	42	1.09e-04	-0.345000	4.92e-04
Transcriptional regulation by RUNX2	116	1.39e-10	-0.345000	2.15e-09
G2/M DNA damage checkpoint	58	5.64e-06	-0.344000	3.45e-05
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	2.09e-02	-0.344000	4.72e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	22	5.20e-03	-0.344000	1.43e-02
Neurodegenerative Diseases	22	5.20e-03	-0.344000	1.43e-02
Glucuronidation	25	2.91e-03	0.344000	8.77e-03
Metabolism of Angiotensinogen to Angiotensins	15	2.13e-02	0.343000	4.80e-02
S Phase	157	1.12e-13	-0.343000	2.56e-12
Cell Cycle Checkpoints	248	1.21e-20	-0.343000	4.88e-19
Regulation of PTEN stability and activity	66	1.45e-06	-0.343000	9.67e-06
Mitotic Metaphase and Anaphase	222	1.21e-18	-0.343000	3.77e-17
Impaired BRCA2 binding to RAD51	33	6.58e-04	-0.342000	2.38e-03
Activation of NF-kappaB in B cells	64	2.21e-06	-0.342000	1.43e-05
Transcription of E2F targets under negative control by DREAM complex	19	9.91e-03	-0.342000	2.49e-02
Glutamate and glutamine metabolism	12	4.08e-02	-0.341000	8.08e-02
Mitotic Anaphase	221	2.39e-18	-0.340000	7.29e-17
Activation of SMO	17	1.55e-02	-0.339000	3.66e-02
The citric acid (TCA) cycle and respiratory electron transport	143	2.65e-12	-0.338000	5.54e-11
SUMOylation of DNA methylation proteins	16	1.92e-02	-0.338000	4.38e-02
Zinc influx into cells by the SLC39 gene family	10	6.44e-02	-0.338000	1.17e-01
Formation of HIV elongation complex in the absence of HIV Tat	40	2.20e-04	-0.337000	8.98e-04
TCF dependent signaling in response to WNT	168	4.18e-14	-0.337000	9.82e-13
eNOS activation	11	5.31e-02	-0.337000	9.96e-02
Synthesis of DNA	118	2.86e-10	-0.336000	4.12e-09
Hedgehog ‘on’ state	83	1.23e-07	-0.336000	9.93e-07
Postmitotic nuclear pore complex (NPC) reformation	26	3.07e-03	-0.335000	9.13e-03
Deadenylation-dependent mRNA decay	56	1.41e-05	-0.335000	8.17e-05
RNA Polymerase II Pre-transcription Events	73	7.43e-07	-0.335000	5.21e-06
Resolution of Sister Chromatid Cohesion	98	1.06e-08	-0.334000	1.08e-07
RNA Polymerase II Transcription Termination	62	5.31e-06	-0.334000	3.30e-05
tRNA processing	98	1.08e-08	-0.334000	1.08e-07
Regulation of pyruvate dehydrogenase (PDH) complex	14	3.06e-02	-0.334000	6.38e-02
Formation of RNA Pol II elongation complex	53	2.63e-05	-0.334000	1.43e-04
RNA Polymerase II Transcription Elongation	53	2.63e-05	-0.334000	1.43e-04
Transport of organic anions	10	6.77e-02	0.333000	1.21e-01
IRE1alpha activates chaperones	50	4.52e-05	-0.333000	2.23e-04
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	5.65e-02	-0.332000	1.04e-01
Caspase activation via Death Receptors in the presence of ligand	16	2.21e-02	-0.330000	4.91e-02
Transcriptional regulation of testis differentiation	12	4.76e-02	-0.330000	9.17e-02
APC/C:Cdc20 mediated degradation of Cyclin B	24	5.11e-03	-0.330000	1.42e-02
APC truncation mutants have impaired AXIN binding	13	3.93e-02	-0.330000	7.83e-02
AXIN missense mutants destabilize the destruction complex	13	3.93e-02	-0.330000	7.83e-02
Signaling by AMER1 mutants	13	3.93e-02	-0.330000	7.83e-02
Signaling by APC mutants	13	3.93e-02	-0.330000	7.83e-02
Signaling by AXIN mutants	13	3.93e-02	-0.330000	7.83e-02
Truncations of AMER1 destabilize the destruction complex	13	3.93e-02	-0.330000	7.83e-02
Regulation of Complement cascade	45	1.28e-04	0.330000	5.57e-04
Activation of AMPK downstream of NMDARs	10	7.11e-02	-0.330000	1.26e-01
Regulation of beta-cell development	41	2.59e-04	-0.330000	1.04e-03
Deactivation of the beta-catenin transactivating complex	39	3.68e-04	-0.329000	1.43e-03
tRNA Aminoacylation	24	5.30e-03	-0.329000	1.46e-02
Nucleotide biosynthesis	14	3.36e-02	-0.328000	6.92e-02
Regulation of TP53 Activity	154	2.14e-12	-0.328000	4.60e-11
mRNA 3’-end processing	53	3.77e-05	-0.327000	1.89e-04
Reversible hydration of carbon dioxide	11	6.08e-02	-0.326000	1.11e-01
Translation of Structural Proteins	29	2.45e-03	-0.325000	7.53e-03
Activated NTRK2 signals through FRS2 and FRS3	11	6.21e-02	-0.325000	1.13e-01
NOTCH1 Intracellular Domain Regulates Transcription	44	2.01e-04	-0.324000	8.33e-04
Transcription of the HIV genome	62	1.03e-05	-0.324000	6.05e-05
RHO GTPases Activate Formins	114	2.30e-09	-0.324000	2.89e-08
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	1.22e-02	-0.323000	2.99e-02
Downstream signaling events of B Cell Receptor (BCR)	78	7.73e-07	-0.323000	5.39e-06
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	89	1.31e-07	-0.323000	1.04e-06
Amplification of signal from the kinetochores	89	1.31e-07	-0.323000	1.04e-06
HDR through Single Strand Annealing (SSA)	36	7.90e-04	-0.323000	2.79e-03
Ub-specific processing proteases	157	2.72e-12	-0.323000	5.62e-11
Transcriptional Regulation by TP53	346	4.54e-25	-0.323000	3.15e-23
Complement cascade	56	2.94e-05	0.323000	1.53e-04
Signaling by FLT3 ITD and TKD mutants	16	2.56e-02	-0.322000	5.54e-02
FGFR2 mutant receptor activation	32	1.62e-03	-0.322000	5.23e-03
Transcriptional regulation by small RNAs	46	1.60e-04	-0.322000	6.79e-04
RUNX3 regulates NOTCH signaling	13	4.49e-02	-0.321000	8.70e-02
NOTCH4 Intracellular Domain Regulates Transcription	19	1.54e-02	-0.321000	3.63e-02
Nucleotide Excision Repair	107	9.41e-09	-0.321000	9.59e-08
Mitotic Spindle Checkpoint	106	1.14e-08	-0.321000	1.14e-07
Interleukin-27 signaling	11	6.60e-02	-0.320000	1.18e-01
MAPK6/MAPK4 signaling	89	1.80e-07	-0.320000	1.42e-06
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	1.25e-03	-0.320000	4.20e-03
SHC-mediated cascade:FGFR3	17	2.24e-02	-0.320000	4.96e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.48e-06	-0.319000	9.81e-06
SUMOylation of SUMOylation proteins	33	1.54e-03	-0.319000	5.00e-03
RUNX2 regulates bone development	29	3.03e-03	-0.318000	9.07e-03
Mitophagy	27	4.33e-03	-0.317000	1.24e-02
Glutathione synthesis and recycling	13	4.78e-02	-0.317000	9.20e-02
RHO GTPases Activate WASPs and WAVEs	34	1.40e-03	-0.316000	4.61e-03
p75NTR recruits signalling complexes	12	5.81e-02	-0.316000	1.06e-01
Repression of WNT target genes	13	4.87e-02	-0.316000	9.35e-02
Regulation of TNFR1 signaling	32	2.01e-03	-0.315000	6.36e-03
Fertilization	26	5.39e-03	0.315000	1.47e-02
RNA polymerase II transcribes snRNA genes	77	1.74e-06	-0.315000	1.14e-05
SUMOylation of chromatin organization proteins	54	6.46e-05	-0.314000	3.07e-04
RNA Polymerase III Abortive And Retractive Initiation	41	4.99e-04	-0.314000	1.89e-03
RNA Polymerase III Transcription	41	4.99e-04	-0.314000	1.89e-03
Cleavage of the damaged pyrimidine	16	3.02e-02	-0.313000	6.32e-02
Depyrimidination	16	3.02e-02	-0.313000	6.32e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	3.02e-02	-0.313000	6.32e-02
FCERI mediated NF-kB activation	74	3.39e-06	-0.312000	2.16e-05
Interactions of Rev with host cellular proteins	35	1.39e-03	-0.312000	4.58e-03
Rev-mediated nuclear export of HIV RNA	33	1.92e-03	-0.312000	6.10e-03
Phosphorylation of the APC/C	20	1.58e-02	-0.312000	3.71e-02
Transcriptional Regulation by E2F6	32	2.29e-03	-0.311000	7.16e-03
Telomere Maintenance	62	2.32e-05	-0.311000	1.28e-04
IKK complex recruitment mediated by RIP1	22	1.17e-02	-0.310000	2.89e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	6.29e-02	-0.310000	1.14e-01
TRAF3-dependent IRF activation pathway	15	3.76e-02	-0.310000	7.59e-02
Unfolded Protein Response (UPR)	91	3.21e-07	-0.310000	2.38e-06
Metabolism of non-coding RNA	50	1.53e-04	-0.309000	6.56e-04
snRNP Assembly	50	1.53e-04	-0.309000	6.56e-04
Maturation of nucleoprotein	11	7.61e-02	-0.309000	1.33e-01
GABA synthesis, release, reuptake and degradation	19	1.98e-02	-0.309000	4.50e-02
Activation of the AP-1 family of transcription factors	10	9.14e-02	-0.308000	1.54e-01
Export of Viral Ribonucleoproteins from Nucleus	31	3.00e-03	-0.308000	9.02e-03
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	5.46e-02	-0.308000	1.01e-01
Signaling by Erythropoietin	25	7.74e-03	-0.308000	1.99e-02
Chemokine receptors bind chemokines	56	6.80e-05	0.308000	3.21e-04
Scavenging of heme from plasma	12	6.52e-02	0.307000	1.17e-01
TNFR1-induced proapoptotic signaling	13	5.51e-02	-0.307000	1.02e-01
Diseases of DNA repair	49	1.98e-04	-0.307000	8.23e-04
Formation of the Early Elongation Complex	32	2.63e-03	-0.307000	8.04e-03
Formation of the HIV-1 Early Elongation Complex	32	2.63e-03	-0.307000	8.04e-03
Condensation of Prophase Chromosomes	12	6.55e-02	-0.307000	1.18e-01
Interleukin-7 signaling	21	1.49e-02	-0.307000	3.53e-02
Phospholipase C-mediated cascade: FGFR1	16	3.36e-02	-0.307000	6.92e-02
KEAP1-NFE2L2 pathway	103	8.33e-08	-0.305000	6.88e-07
ATF6 (ATF6-alpha) activates chaperone genes	10	9.45e-02	-0.305000	1.58e-01
Mitotic G2-G2/M phases	178	2.05e-12	-0.305000	4.47e-11
Activation of gene expression by SREBF (SREBP)	42	6.37e-04	-0.304000	2.33e-03
Dectin-2 family	28	5.29e-03	0.304000	1.46e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	3.90e-03	-0.304000	1.14e-02
Processing of DNA double-strand break ends	61	3.94e-05	-0.304000	1.97e-04
Response to metal ions	14	4.88e-02	-0.304000	9.35e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	1.14e-04	-0.303000	5.06e-04
Recycling of bile acids and salts	18	2.58e-02	0.303000	5.58e-02
Intrinsic Pathway for Apoptosis	52	1.53e-04	-0.303000	6.56e-04
Negative regulators of DDX58/IFIH1 signaling	34	2.20e-03	-0.303000	6.92e-03
G2/M Transition	176	3.67e-12	-0.303000	7.10e-11
Formation of the cornified envelope	74	6.54e-06	0.303000	3.97e-05
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	1.17e-04	-0.303000	5.12e-04
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	1.17e-04	-0.303000	5.12e-04
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	1.17e-04	-0.303000	5.12e-04
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	1.17e-04	-0.303000	5.12e-04
Signaling by NOTCH1 in Cancer	54	1.17e-04	-0.303000	5.12e-04
DNA Double Strand Break Response	42	6.92e-04	-0.302000	2.49e-03
SUMOylation of RNA binding proteins	45	4.47e-04	-0.302000	1.73e-03
Regulation of TP53 Activity through Acetylation	29	4.89e-03	-0.302000	1.37e-02
Toll Like Receptor 3 (TLR3) Cascade	88	9.94e-07	-0.302000	6.84e-06
Signaling by NTRKs	133	1.89e-09	-0.301000	2.39e-08
Zinc transporters	17	3.15e-02	-0.301000	6.53e-02
EML4 and NUDC in mitotic spindle formation	93	5.08e-07	-0.301000	3.66e-06
Defects in vitamin and cofactor metabolism	20	1.98e-02	-0.301000	4.50e-02
Branched-chain amino acid catabolism	20	1.98e-02	-0.301000	4.50e-02
rRNA modification in the nucleus and cytosol	55	1.14e-04	-0.301000	5.06e-04
Cell Cycle, Mitotic	477	1.99e-29	-0.300000	1.79e-27
CLEC7A (Dectin-1) signaling	96	3.99e-07	-0.299000	2.91e-06
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	1.66e-03	-0.299000	5.34e-03
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	1.27e-03	-0.298000	4.23e-03
Diseases of DNA Double-Strand Break Repair	39	1.27e-03	-0.298000	4.23e-03
Syndecan interactions	19	2.48e-02	-0.297000	5.42e-02
Sensory perception of taste	47	4.21e-04	0.297000	1.63e-03
Killing mechanisms	11	8.78e-02	-0.297000	1.50e-01
WNT5:FZD7-mediated leishmania damping	11	8.78e-02	-0.297000	1.50e-01
LDL clearance	19	2.49e-02	-0.297000	5.43e-02
SARS-CoV-2 modulates autophagy	11	8.84e-02	-0.297000	1.50e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	44	6.62e-04	-0.297000	2.39e-03
Dual incision in TC-NER	63	4.76e-05	-0.296000	2.34e-04
Neddylation	228	1.26e-14	-0.296000	3.05e-13
HATs acetylate histones	71	1.62e-05	-0.296000	9.22e-05
Nuclear Envelope (NE) Reassembly	73	1.23e-05	-0.296000	7.19e-05
Formation of tubulin folding intermediates by CCT/TriC	26	9.13e-03	-0.295000	2.32e-02
M Phase	336	1.15e-20	-0.295000	4.74e-19
Cellular responses to stimuli	697	1.53e-40	-0.295000	2.34e-38
Homologous DNA Pairing and Strand Exchange	41	1.10e-03	-0.294000	3.72e-03
Cellular responses to stress	683	1.20e-39	-0.294000	1.67e-37
Transport of Mature Transcript to Cytoplasm	76	9.07e-06	-0.294000	5.39e-05
SHC-mediated cascade:FGFR4	19	2.64e-02	-0.294000	5.68e-02
DNA Double-Strand Break Repair	130	6.72e-09	-0.294000	7.08e-08
MicroRNA (miRNA) biogenesis	26	9.41e-03	-0.294000	2.38e-02
Cytosolic sensors of pathogen-associated DNA	60	8.12e-05	-0.294000	3.78e-04
Selective autophagy	59	9.67e-05	-0.293000	4.38e-04
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	7.85e-02	-0.293000	1.37e-01
alpha-linolenic acid (ALA) metabolism	12	7.85e-02	-0.293000	1.37e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	41	1.16e-03	-0.293000	3.92e-03
RNA Polymerase III Transcription Initiation	36	2.34e-03	-0.293000	7.26e-03
TRAF6 mediated NF-kB activation	24	1.32e-02	-0.292000	3.19e-02
Interleukin-1 signaling	97	6.49e-07	-0.292000	4.61e-06
Common Pathway of Fibrin Clot Formation	21	2.05e-02	0.292000	4.63e-02
Regulated proteolysis of p75NTR	11	9.36e-02	-0.292000	1.56e-01
Mitotic Prometaphase	175	2.69e-11	-0.292000	4.56e-10
FGFR1 ligand binding and activation	15	5.07e-02	-0.291000	9.63e-02
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	41	1.25e-03	-0.291000	4.20e-03
Acetylcholine regulates insulin secretion	10	1.11e-01	0.291000	1.81e-01
Downregulation of TGF-beta receptor signaling	26	1.02e-02	-0.291000	2.55e-02
Basigin interactions	24	1.37e-02	-0.291000	3.26e-02
Mitochondrial biogenesis	69	3.01e-05	-0.290000	1.56e-04
Cholesterol biosynthesis	24	1.38e-02	-0.290000	3.29e-02
Synthesis of PC	27	9.06e-03	-0.290000	2.31e-02
Apoptosis	164	1.56e-10	-0.289000	2.31e-09
Formation of the beta-catenin:TCF transactivating complex	32	4.63e-03	-0.289000	1.31e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	5.28e-02	-0.289000	9.92e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	5.28e-02	-0.289000	9.92e-02
Metabolism of nitric oxide: NOS3 activation and regulation	15	5.28e-02	-0.289000	9.92e-02
Transport of Mature mRNA Derived from an Intronless Transcript	40	1.59e-03	-0.288000	5.16e-03
ATF6 (ATF6-alpha) activates chaperones	11	9.77e-02	-0.288000	1.62e-01
Negative regulation of FLT3	15	5.39e-02	-0.287000	1.01e-01
Cytosolic iron-sulfur cluster assembly	10	1.16e-01	-0.287000	1.86e-01
Downstream signal transduction	29	7.40e-03	-0.287000	1.92e-02
Gap-filling DNA repair synthesis and ligation in TC-NER	62	9.11e-05	-0.287000	4.19e-04
ER-Phagosome pathway	87	3.60e-06	-0.287000	2.28e-05
Protein localization	147	1.81e-09	-0.287000	2.33e-08
NEP/NS2 Interacts with the Cellular Export Machinery	30	6.54e-03	-0.287000	1.74e-02
HIV Life Cycle	139	5.27e-09	-0.287000	5.68e-08
DNA strand elongation	31	5.80e-03	-0.286000	1.56e-02
Formation of Incision Complex in GG-NER	40	1.75e-03	-0.286000	5.63e-03
Presynaptic phase of homologous DNA pairing and strand exchange	38	2.35e-03	-0.285000	7.29e-03
Potential therapeutics for SARS	83	7.25e-06	-0.285000	4.36e-05
FRS-mediated FGFR1 signaling	23	1.81e-02	-0.285000	4.15e-02
Signaling by CSF3 (G-CSF)	28	9.18e-03	-0.284000	2.33e-02
Activation of ATR in response to replication stress	37	2.80e-03	-0.284000	8.47e-03
Diseases associated with glycosylation precursor biosynthesis	15	5.72e-02	-0.284000	1.05e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	1.08e-02	-0.283000	2.69e-02
p75NTR signals via NF-kB	15	5.79e-02	-0.283000	1.06e-01
AURKA Activation by TPX2	68	5.65e-05	-0.282000	2.75e-04
Signaling by WNT	263	2.94e-15	-0.282000	7.25e-14
Class I peroxisomal membrane protein import	19	3.31e-02	-0.282000	6.83e-02
Sema4D induced cell migration and growth-cone collapse	20	2.89e-02	-0.282000	6.14e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	2.68e-05	-0.282000	1.45e-04
Nuclear import of Rev protein	32	5.75e-03	-0.282000	1.55e-02
Telomere Extension By Telomerase	22	2.22e-02	-0.282000	4.93e-02
Hedgehog ‘off’ state	97	1.63e-06	-0.281000	1.07e-05
SUMOylation of transcription cofactors	43	1.40e-03	-0.281000	4.61e-03
PRC2 methylates histones and DNA	13	7.90e-02	-0.281000	1.38e-01
Vpr-mediated nuclear import of PICs	32	5.94e-03	-0.281000	1.59e-02
Signaling by ALK	26	1.32e-02	-0.281000	3.19e-02
Cell Cycle	602	3.52e-32	-0.281000	4.13e-30
Regulation of HSF1-mediated heat shock response	78	1.80e-05	-0.281000	1.02e-04
Removal of the Flap Intermediate from the C-strand	17	4.53e-02	-0.280000	8.76e-02
SARS-CoV-1 Infection	51	5.36e-04	-0.280000	2.00e-03
Generic Transcription Pathway	1150	2.24e-58	-0.280000	4.88e-56
Energy dependent regulation of mTOR by LKB1-AMPK	28	1.04e-02	-0.280000	2.60e-02
Late Phase of HIV Life Cycle	126	5.87e-08	-0.279000	5.10e-07
PERK regulates gene expression	32	6.22e-03	-0.279000	1.66e-02
VLDLR internalisation and degradation	16	5.32e-02	-0.279000	9.96e-02
DNA Repair	277	1.20e-15	-0.279000	3.11e-14
Transport of Mature mRNA derived from an Intron-Containing Transcript	67	7.83e-05	-0.279000	3.66e-04
RNA Polymerase II Transcription	1271	1.57e-63	-0.279000	5.98e-61
Interactions of Vpr with host cellular proteins	33	5.61e-03	-0.278000	1.52e-02
RHO GTPases activate CIT	19	3.62e-02	-0.278000	7.31e-02
Global Genome Nucleotide Excision Repair (GG-NER)	81	1.55e-05	-0.278000	8.95e-05
SUMOylation of DNA replication proteins	44	1.44e-03	-0.278000	4.71e-03
Signaling by FGFR2 in disease	42	1.85e-03	-0.277000	5.92e-03
HS-GAG degradation	18	4.17e-02	-0.277000	8.20e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	1.12e-02	-0.277000	2.76e-02
Gene expression (Transcription)	1407	6.19e-69	-0.277000	4.73e-66
Regulation of IFNG signaling	14	7.33e-02	-0.276000	1.29e-01
TP53 Regulates Transcription of Cell Death Genes	42	1.93e-03	-0.276000	6.14e-03
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	23	2.17e-02	-0.276000	4.85e-02
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	23	2.17e-02	-0.276000	4.85e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	23	2.17e-02	-0.276000	4.85e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	23	2.17e-02	-0.276000	4.85e-02
Impaired BRCA2 binding to PALB2	23	2.17e-02	-0.276000	4.85e-02
Receptor Mediated Mitophagy	10	1.31e-01	-0.276000	2.05e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	4.27e-02	-0.276000	8.35e-02
Transcriptional activation of mitochondrial biogenesis	51	6.58e-04	-0.276000	2.38e-03
ESR-mediated signaling	160	1.73e-09	-0.276000	2.24e-08
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	7.43e-02	-0.275000	1.31e-01
Protein folding	96	3.08e-06	-0.275000	1.97e-05
Deubiquitination	230	5.93e-13	-0.275000	1.33e-11
Inactivation of CSF3 (G-CSF) signaling	23	2.23e-02	-0.275000	4.96e-02
MyD88 cascade initiated on plasma membrane	79	2.35e-05	-0.275000	1.28e-04
Toll Like Receptor 10 (TLR10) Cascade	79	2.35e-05	-0.275000	1.28e-04
Toll Like Receptor 5 (TLR5) Cascade	79	2.35e-05	-0.275000	1.28e-04
Signaling by NOTCH2	32	7.16e-03	-0.275000	1.87e-02
Regulation of TP53 Expression and Degradation	37	3.84e-03	-0.275000	1.12e-02
MyD88-independent TLR4 cascade	92	5.59e-06	-0.274000	3.43e-05
TRIF(TICAM1)-mediated TLR4 signaling	92	5.59e-06	-0.274000	3.43e-05
Cellular Senescence	130	7.12e-08	-0.273000	6.01e-07
Free fatty acids regulate insulin secretion	10	1.35e-01	0.273000	2.09e-01
Chromatin modifying enzymes	185	1.46e-10	-0.273000	2.19e-09
Chromatin organization	185	1.46e-10	-0.273000	2.19e-09
Miscellaneous transport and binding events	21	3.05e-02	-0.273000	6.37e-02
Chaperonin-mediated protein folding	90	7.83e-06	-0.272000	4.69e-05
Signaling by FGFR2	72	6.44e-05	-0.272000	3.07e-04
Chromosome Maintenance	86	1.27e-05	-0.272000	7.37e-05
Removal of the Flap Intermediate	13	8.94e-02	-0.272000	1.52e-01
ER Quality Control Compartment (ERQC)	20	3.55e-02	-0.272000	7.23e-02
Gluconeogenesis	32	7.95e-03	-0.271000	2.04e-02
Cytochrome c-mediated apoptotic response	12	1.04e-01	-0.271000	1.72e-01
MASTL Facilitates Mitotic Progression	10	1.38e-01	-0.270000	2.13e-01
Androgen biosynthesis	11	1.21e-01	0.270000	1.92e-01
TNFR2 non-canonical NF-kB pathway	94	6.16e-06	-0.270000	3.75e-05
Interleukin-35 Signalling	12	1.06e-01	-0.269000	1.74e-01
Signaling by NOTCH1	70	9.59e-05	-0.269000	4.38e-04
Host Interactions of HIV factors	122	2.69e-07	-0.269000	2.03e-06
HIV Infection	216	8.33e-12	-0.269000	1.53e-10
ATF4 activates genes in response to endoplasmic reticulum stress	28	1.36e-02	-0.269000	3.26e-02
MyD88 dependent cascade initiated on endosome	84	1.98e-05	-0.269000	1.10e-04
Toll Like Receptor 7/8 (TLR7/8) Cascade	84	1.98e-05	-0.269000	1.10e-04
DARPP-32 events	24	2.33e-02	-0.267000	5.12e-02
SUMOylation	164	3.38e-09	-0.267000	3.91e-08
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	1.43e-01	-0.267000	2.19e-01
PTEN Regulation	150	1.76e-08	-0.266000	1.68e-07
Oncogene Induced Senescence	35	6.41e-03	-0.266000	1.71e-02
COPI-dependent Golgi-to-ER retrograde traffic	81	3.50e-05	-0.266000	1.77e-04
Synaptic adhesion-like molecules	19	4.49e-02	-0.266000	8.70e-02
CaMK IV-mediated phosphorylation of CREB	10	1.46e-01	-0.266000	2.22e-01
Regulation of TP53 Degradation	36	5.90e-03	-0.265000	1.58e-02
Homology Directed Repair	100	4.76e-06	-0.265000	2.98e-05
Base Excision Repair	45	2.14e-03	-0.264000	6.73e-03
SUMO E3 ligases SUMOylate target proteins	158	9.33e-09	-0.264000	9.59e-08
Nonhomologous End-Joining (NHEJ)	32	9.67e-03	-0.264000	2.43e-02
Metabolism of amino acids and derivatives	345	3.43e-17	-0.264000	9.19e-16
NF-kB is activated and signals survival	12	1.14e-01	-0.263000	1.85e-01
Resolution of Abasic Sites (AP sites)	37	5.61e-03	-0.263000	1.52e-02
Caspase activation via extrinsic apoptotic signalling pathway	25	2.29e-02	-0.263000	5.05e-02
Transport of the SLBP Dependant Mature mRNA	34	8.01e-03	-0.263000	2.06e-02
TBC/RABGAPs	42	3.24e-03	-0.262000	9.55e-03
Formation of Fibrin Clot (Clotting Cascade)	37	5.85e-03	0.262000	1.57e-02
Loss of Nlp from mitotic centrosomes	65	2.67e-04	-0.261000	1.06e-03
Loss of proteins required for interphase microtubule organization from the centrosome	65	2.67e-04	-0.261000	1.06e-03
Beta-catenin independent WNT signaling	144	6.19e-08	-0.261000	5.28e-07
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	83	3.90e-05	-0.261000	1.96e-04
RAB geranylgeranylation	57	6.55e-04	-0.261000	2.38e-03
TNF signaling	40	4.31e-03	-0.261000	1.24e-02
Keratan sulfate degradation	12	1.18e-01	0.261000	1.89e-01
CTNNB1 S33 mutants aren’t phosphorylated	14	9.16e-02	-0.260000	1.54e-01
CTNNB1 S37 mutants aren’t phosphorylated	14	9.16e-02	-0.260000	1.54e-01
CTNNB1 S45 mutants aren’t phosphorylated	14	9.16e-02	-0.260000	1.54e-01
CTNNB1 T41 mutants aren’t phosphorylated	14	9.16e-02	-0.260000	1.54e-01
Signaling by CTNNB1 phospho-site mutants	14	9.16e-02	-0.260000	1.54e-01
Signaling by GSK3beta mutants	14	9.16e-02	-0.260000	1.54e-01
Nervous system development	527	1.79e-24	-0.259000	1.14e-22
Transport of Ribonucleoproteins into the Host Nucleus	30	1.40e-02	-0.259000	3.33e-02
HDR through Homologous Recombination (HRR)	65	3.03e-04	-0.259000	1.19e-03
Downstream TCR signaling	92	1.74e-05	-0.259000	9.85e-05
VEGFR2 mediated cell proliferation	19	5.07e-02	-0.259000	9.63e-02
Transferrin endocytosis and recycling	30	1.43e-02	-0.258000	3.40e-02
Iron uptake and transport	57	7.45e-04	-0.258000	2.65e-03
Axon guidance	503	3.12e-23	-0.258000	1.77e-21
Signaling by TGF-beta Receptor Complex	86	3.61e-05	-0.258000	1.82e-04
Synthesis of substrates in N-glycan biosythesis	60	5.73e-04	-0.257000	2.13e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	2.65e-02	-0.256000	5.71e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	94	1.74e-05	-0.256000	9.85e-05
Transport of the SLBP independent Mature mRNA	33	1.09e-02	-0.256000	2.70e-02
Cellular response to heat stress	95	1.59e-05	-0.256000	9.12e-05
LGI-ADAM interactions	14	9.72e-02	-0.256000	1.61e-01
Glycolysis	68	2.60e-04	-0.256000	1.04e-03
EPH-Ephrin signaling	90	2.70e-05	-0.256000	1.45e-04
mRNA Editing	10	1.61e-01	0.256000	2.41e-01
Toll Like Receptor 9 (TLR9) Cascade	88	3.55e-05	-0.255000	1.80e-04
TP53 Regulates Metabolic Genes	83	6.10e-05	-0.254000	2.93e-04
Neurotoxicity of clostridium toxins	10	1.64e-01	-0.254000	2.44e-01
tRNA modification in the nucleus and cytosol	38	6.91e-03	-0.253000	1.82e-02
Activation of BAD and translocation to mitochondria	15	8.98e-02	-0.253000	1.52e-01
RHO GTPases activate KTN1	11	1.48e-01	-0.252000	2.25e-01
HDMs demethylate histones	18	6.47e-02	-0.251000	1.17e-01
Signaling by FGFR	85	6.23e-05	-0.251000	2.98e-04
Cellular response to chemical stress	187	3.09e-09	-0.251000	3.66e-08
Signaling by NOTCH	183	4.73e-09	-0.251000	5.13e-08
Caspase-mediated cleavage of cytoskeletal proteins	12	1.33e-01	-0.250000	2.08e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	31	1.61e-02	-0.250000	3.76e-02
Mitotic Prophase	78	1.38e-04	-0.249000	6.00e-04
SUMOylation of DNA damage response and repair proteins	71	2.78e-04	-0.249000	1.10e-03
Activation of Matrix Metalloproteinases	31	1.64e-02	0.249000	3.82e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity	26	2.80e-02	-0.249000	5.98e-02
Deadenylation of mRNA	25	3.12e-02	-0.249000	6.50e-02
EPH-ephrin mediated repulsion of cells	48	2.88e-03	-0.249000	8.70e-03
EGR2 and SOX10-mediated initiation of Schwann cell myelination	27	2.54e-02	-0.249000	5.50e-02
Signaling by PDGFRA extracellular domain mutants	12	1.36e-01	-0.248000	2.11e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	1.36e-01	-0.248000	2.11e-01
Glucose metabolism	87	6.35e-05	-0.248000	3.03e-04
Antigen processing-Cross presentation	102	1.56e-05	-0.247000	8.95e-05
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	9.75e-02	-0.247000	1.62e-01
RHOBTB1 GTPase cycle	22	4.48e-02	-0.247000	8.70e-02
Regulation of PLK1 Activity at G2/M Transition	83	1.00e-04	-0.247000	4.51e-04
Programmed Cell Death	192	3.53e-09	-0.247000	4.06e-08
Signaling by KIT in disease	20	5.70e-02	-0.246000	1.05e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	5.70e-02	-0.246000	1.05e-01
Creation of C4 and C2 activators	14	1.13e-01	0.245000	1.83e-01
Synthesis, secretion, and deacylation of Ghrelin	19	6.47e-02	-0.245000	1.17e-01
SUMOylation of ubiquitinylation proteins	37	1.01e-02	-0.244000	2.52e-02
Class B/2 (Secretin family receptors)	94	4.18e-05	-0.244000	2.07e-04
Regulation of FZD by ubiquitination	21	5.28e-02	-0.244000	9.92e-02
Mitochondrial calcium ion transport	22	4.75e-02	-0.244000	9.17e-02
Regulation of TP53 Activity through Methylation	18	7.32e-02	-0.244000	1.29e-01
MAP kinase activation	58	1.34e-03	-0.243000	4.45e-03
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.63e-01	-0.243000	2.43e-01
ABC transporter disorders	75	2.83e-04	-0.242000	1.12e-03
Resolution of D-Loop Structures	32	1.77e-02	-0.242000	4.06e-02
Lysosome Vesicle Biogenesis	33	1.60e-02	-0.242000	3.75e-02
Transcriptional regulation by RUNX1	183	1.67e-08	-0.242000	1.60e-07
Signaling by NTRK3 (TRKC)	17	8.47e-02	-0.241000	1.46e-01
NOTCH3 Intracellular Domain Regulates Transcription	24	4.07e-02	-0.241000	8.07e-02
Interleukin-6 signaling	11	1.68e-01	-0.240000	2.48e-01
Nuclear Pore Complex (NPC) Disassembly	34	1.54e-02	-0.240000	3.63e-02
FLT3 signaling in disease	28	2.81e-02	-0.240000	5.99e-02
RHO GTPases activate PKNs	34	1.57e-02	-0.239000	3.69e-02
Ethanol oxidation	12	1.51e-01	0.239000	2.28e-01
Phospholipase C-mediated cascade; FGFR3	12	1.52e-01	-0.239000	2.29e-01
Platelet Adhesion to exposed collagen	13	1.37e-01	0.238000	2.11e-01
Glutathione conjugation	37	1.23e-02	-0.238000	2.99e-02
Activation of BH3-only proteins	30	2.44e-02	-0.237000	5.35e-02
FRS-mediated FGFR3 signaling	19	7.36e-02	-0.237000	1.30e-01
Signaling by NOTCH3	48	4.55e-03	-0.237000	1.29e-02
SHC-mediated cascade:FGFR2	22	5.48e-02	-0.236000	1.02e-01
MAPK3 (ERK1) activation	10	1.96e-01	-0.236000	2.80e-01
Signaling by Hedgehog	133	2.58e-06	-0.236000	1.66e-05
RHOBTB GTPase Cycle	34	1.74e-02	-0.236000	4.01e-02
Calcitonin-like ligand receptors	10	1.98e-01	-0.235000	2.82e-01
Synthesis of bile acids and bile salts	34	1.85e-02	0.233000	4.23e-02
Post-chaperonin tubulin folding pathway	23	5.29e-02	-0.233000	9.92e-02
Butyrophilin (BTN) family interactions	12	1.62e-01	0.233000	2.42e-01
RHO GTPase Effectors	232	9.15e-10	-0.233000	1.23e-08
Elastic fibre formation	41	9.91e-03	-0.233000	2.49e-02
Signaling by FLT3 fusion proteins	19	7.93e-02	-0.232000	1.38e-01
Extension of Telomeres	48	5.33e-03	-0.232000	1.46e-02
TGF-beta receptor signaling activates SMADs	45	7.06e-03	-0.232000	1.86e-02
BBSome-mediated cargo-targeting to cilium	23	5.43e-02	-0.232000	1.01e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	1.48e-01	-0.232000	2.25e-01
Signaling by FGFR1	49	5.06e-03	-0.231000	1.41e-02
FLT3 Signaling	38	1.36e-02	-0.231000	3.26e-02
ISG15 antiviral mechanism	71	7.54e-04	-0.231000	2.67e-03
Circadian Clock	69	8.97e-04	-0.231000	3.09e-03
Processive synthesis on the C-strand of the telomere	19	8.17e-02	-0.231000	1.41e-01
Signal attenuation	10	2.07e-01	-0.230000	2.93e-01
Asparagine N-linked glycosylation	278	4.21e-11	-0.230000	6.92e-10
Metabolism of proteins	1774	5.10e-59	-0.229000	1.56e-56
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	1.01e-01	-0.229000	1.68e-01
Sema4D in semaphorin signaling	24	5.23e-02	-0.229000	9.90e-02
Platelet sensitization by LDL	17	1.03e-01	-0.228000	1.70e-01
Oxidative Stress Induced Senescence	66	1.35e-03	-0.228000	4.48e-03
Signaling by TGFB family members	114	2.70e-05	-0.227000	1.45e-04
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	4.90e-02	-0.227000	9.36e-02
Insulin receptor recycling	25	4.90e-02	-0.227000	9.36e-02
Regulation of gene expression in beta cells	21	7.17e-02	-0.227000	1.27e-01
Physiological factors	12	1.74e-01	-0.227000	2.55e-01
RET signaling	41	1.21e-02	-0.226000	2.96e-02
COPI-mediated anterograde transport	83	3.62e-04	-0.226000	1.41e-03
MTOR signalling	40	1.34e-02	-0.226000	3.23e-02
RAS processing	19	8.87e-02	-0.226000	1.51e-01
Pyruvate metabolism	29	3.55e-02	-0.225000	7.24e-02
Formation of apoptosome	10	2.17e-01	-0.225000	3.05e-01
Regulation of the apoptosome activity	10	2.17e-01	-0.225000	3.05e-01
Signaling by FGFR in disease	61	2.36e-03	-0.225000	7.29e-03
Negative regulation of FGFR1 signaling	32	2.77e-02	-0.225000	5.94e-02
RAF activation	33	2.60e-02	-0.224000	5.62e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	5.68e-03	-0.224000	1.54e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	3.40e-02	-0.224000	6.97e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	3.40e-02	-0.224000	6.97e-02
FGFR3 ligand binding and activation	12	1.80e-01	-0.223000	2.62e-01
FGFR3c ligand binding and activation	12	1.80e-01	-0.223000	2.62e-01
HCMV Late Events	54	4.50e-03	-0.223000	1.28e-02
Retrograde neurotrophin signalling	14	1.48e-01	-0.223000	2.25e-01
Activation of the pre-replicative complex	31	3.14e-02	-0.223000	6.53e-02
Initial triggering of complement	21	7.67e-02	0.223000	1.34e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	1.81e-01	-0.223000	2.64e-01
Clathrin-mediated endocytosis	135	7.95e-06	-0.222000	4.75e-05
Attenuation phase	25	5.44e-02	-0.222000	1.01e-01
WNT5A-dependent internalization of FZD4	15	1.36e-01	-0.222000	2.11e-01
Anchoring of the basal body to the plasma membrane	92	2.32e-04	-0.222000	9.40e-04
FRS-mediated FGFR4 signaling	21	7.84e-02	-0.222000	1.37e-01
Telomere C-strand synthesis initiation	11	2.03e-01	-0.221000	2.89e-01
Endosomal/Vacuolar pathway	12	1.85e-01	-0.221000	2.68e-01
Cargo recognition for clathrin-mediated endocytosis	98	1.67e-04	-0.220000	7.07e-04
MET activates RAS signaling	11	2.07e-01	-0.220000	2.93e-01
Antiviral mechanism by IFN-stimulated genes	78	8.22e-04	-0.219000	2.87e-03
HuR (ELAVL1) binds and stabilizes mRNA	10	2.31e-01	-0.219000	3.19e-01
SARS-CoV Infections	339	4.20e-12	-0.219000	8.02e-11
Antigen processing: Ubiquitination & Proteasome degradation	293	1.14e-10	-0.219000	1.81e-09
Acetylcholine Neurotransmitter Release Cycle	16	1.30e-01	-0.218000	2.05e-01
Organelle biogenesis and maintenance	243	4.70e-09	-0.218000	5.13e-08
Nuclear Envelope Breakdown	50	7.68e-03	-0.218000	1.98e-02
Signalling to ERKs	34	2.80e-02	-0.218000	5.98e-02
Bile acid and bile salt metabolism	45	1.15e-02	0.218000	2.85e-02
Toll Like Receptor 4 (TLR4) Cascade	124	2.93e-05	-0.217000	1.53e-04
Golgi-to-ER retrograde transport	115	5.71e-05	-0.217000	2.77e-04
Spry regulation of FGF signaling	16	1.34e-01	-0.217000	2.08e-01
Processing of SMDT1	15	1.47e-01	-0.216000	2.24e-01
Signaling by Retinoic Acid	41	1.65e-02	-0.216000	3.84e-02
Drug ADME	98	2.14e-04	0.216000	8.79e-04
RHO GTPases Activate ROCKs	19	1.03e-01	-0.216000	1.70e-01
EPHB-mediated forward signaling	34	2.93e-02	-0.216000	6.19e-02
Phospholipase C-mediated cascade; FGFR4	14	1.62e-01	-0.216000	2.42e-01
Recruitment of NuMA to mitotic centrosomes	76	1.14e-03	-0.216000	3.85e-03
FGFR1c ligand binding and activation	11	2.16e-01	-0.216000	3.03e-01
Signaling by activated point mutants of FGFR1	11	2.16e-01	-0.216000	3.03e-01
Downstream signaling of activated FGFR3	24	6.76e-02	-0.215000	1.21e-01
Diseases of signal transduction by growth factor receptors and second messengers	410	7.15e-14	-0.215000	1.65e-12
Polymerase switching on the C-strand of the telomere	24	6.86e-02	-0.215000	1.22e-01
Signaling by FGFR3	39	2.03e-02	-0.215000	4.60e-02
Glycogen breakdown (glycogenolysis)	12	1.99e-01	-0.214000	2.83e-01
Leading Strand Synthesis	13	1.82e-01	-0.214000	2.64e-01
Polymerase switching	13	1.82e-01	-0.214000	2.64e-01
Cytoprotection by HMOX1	58	4.86e-03	-0.214000	1.36e-02
Protein ubiquitination	61	3.96e-03	-0.213000	1.15e-02
TCR signaling	112	9.59e-05	-0.213000	4.38e-04
Transcriptional regulation of white adipocyte differentiation	81	9.09e-04	-0.213000	3.13e-03
Processive synthesis on the lagging strand	14	1.68e-01	-0.213000	2.48e-01
Josephin domain DUBs	11	2.22e-01	-0.213000	3.10e-01
Signaling by ERBB2 ECD mutants	15	1.54e-01	-0.213000	2.32e-01
Downstream signaling of activated FGFR1	31	4.07e-02	-0.212000	8.07e-02
Pyruvate metabolism and Citric Acid (TCA) cycle	52	8.14e-03	-0.212000	2.09e-02
Signaling by the B Cell Receptor (BCR)	105	1.73e-04	-0.212000	7.28e-04
FGFR3 mutant receptor activation	11	2.24e-01	-0.212000	3.11e-01
Signaling by activated point mutants of FGFR3	11	2.24e-01	-0.212000	3.11e-01
Interconversion of nucleotide di- and triphosphates	29	4.88e-02	-0.211000	9.35e-02
Protein methylation	16	1.43e-01	-0.211000	2.19e-01
Transcriptional Regulation by VENTX	41	1.92e-02	-0.211000	4.38e-02
Nuclear events stimulated by ALK signaling in cancer	18	1.21e-01	-0.211000	1.92e-01
COPII-mediated vesicle transport	66	3.06e-03	-0.211000	9.10e-03
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27	5.80e-02	-0.211000	1.06e-01
Mismatch Repair	15	1.58e-01	-0.210000	2.38e-01
Peroxisomal protein import	62	4.47e-03	-0.209000	1.28e-02
Glycosphingolipid metabolism	40	2.24e-02	-0.209000	4.96e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	94	4.73e-04	-0.208000	1.80e-03
Toll Like Receptor 2 (TLR2) Cascade	94	4.73e-04	-0.208000	1.80e-03
Toll Like Receptor TLR1:TLR2 Cascade	94	4.73e-04	-0.208000	1.80e-03
Toll Like Receptor TLR6:TLR2 Cascade	94	4.73e-04	-0.208000	1.80e-03
SUMOylation of intracellular receptors	29	5.21e-02	-0.208000	9.88e-02
ER to Golgi Anterograde Transport	134	3.10e-05	-0.208000	1.59e-04
Infection with Mycobacterium tuberculosis	26	6.63e-02	-0.208000	1.19e-01
Regulation of actin dynamics for phagocytic cup formation	59	5.74e-03	-0.208000	1.55e-02
Retrograde transport at the Trans-Golgi-Network	47	1.37e-02	-0.208000	3.26e-02
Uptake and function of anthrax toxins	11	2.33e-01	-0.208000	3.21e-01
Amino acids regulate mTORC1	52	9.53e-03	-0.208000	2.40e-02
Activated NOTCH1 Transmits Signal to the Nucleus	31	4.53e-02	-0.208000	8.76e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37	2.90e-02	-0.207000	6.16e-02
Fc epsilon receptor (FCERI) signaling	126	5.97e-05	-0.207000	2.88e-04
Telomere C-strand (Lagging Strand) Synthesis	32	4.35e-02	-0.206000	8.47e-02
Downstream signaling of activated FGFR4	26	7.06e-02	-0.205000	1.25e-01
SARS-CoV-2 Infection	265	9.38e-09	-0.205000	9.59e-08
trans-Golgi Network Vesicle Budding	67	3.78e-03	-0.204000	1.11e-02
Abacavir ADME	10	2.63e-01	0.204000	3.52e-01
Signaling by FGFR4	40	2.53e-02	-0.204000	5.49e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	38	2.95e-02	-0.204000	6.23e-02
Biotin transport and metabolism	10	2.66e-01	-0.203000	3.55e-01
Infectious disease	885	8.09e-25	-0.203000	5.37e-23
Toll-like Receptor Cascades	143	2.77e-05	-0.203000	1.49e-04
The canonical retinoid cycle in rods (twilight vision)	23	9.33e-02	0.202000	1.56e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	181	2.69e-06	-0.202000	1.73e-05
Adrenaline,noradrenaline inhibits insulin secretion	28	6.46e-02	-0.202000	1.17e-01
Centrosome maturation	77	2.33e-03	-0.201000	7.26e-03
Recruitment of mitotic centrosome proteins and complexes	77	2.33e-03	-0.201000	7.26e-03
Neurotransmitter release cycle	47	1.75e-02	-0.200000	4.03e-02
Regulated Necrosis	53	1.21e-02	-0.199000	2.96e-02
Recognition of DNA damage by PCNA-containing replication complex	29	6.51e-02	-0.198000	1.17e-01
NS1 Mediated Effects on Host Pathways	39	3.28e-02	-0.197000	6.77e-02
Deposition of new CENPA-containing nucleosomes at the centromere	26	8.16e-02	-0.197000	1.41e-01
Nucleosome assembly	26	8.16e-02	-0.197000	1.41e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	1.37e-01	-0.197000	2.11e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	1.37e-01	-0.197000	2.11e-01
RAF/MAP kinase cascade	265	3.52e-08	-0.196000	3.20e-07
MAPK1/MAPK3 signaling	271	2.57e-08	-0.196000	2.40e-07
G beta:gamma signalling through BTK	17	1.62e-01	-0.196000	2.42e-01
Meiotic recombination	26	8.39e-02	-0.196000	1.45e-01
HCMV Early Events	55	1.20e-02	-0.196000	2.96e-02
Elevation of cytosolic Ca2+ levels	16	1.75e-01	-0.196000	2.57e-01
ERBB2 Activates PTK6 Signaling	13	2.22e-01	0.196000	3.10e-01
Signaling by Nuclear Receptors	237	2.11e-07	-0.195000	1.63e-06
Dual Incision in GG-NER	39	3.49e-02	-0.195000	7.13e-02
Assembly Of The HIV Virion	16	1.77e-01	-0.195000	2.59e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	2.63e-01	-0.195000	3.52e-01
Signaling by WNT in cancer	32	5.69e-02	-0.194000	1.05e-01
TNFR1-induced NFkappaB signaling pathway	22	1.15e-01	-0.194000	1.86e-01
Regulation of TP53 Activity through Association with Co-factors	14	2.08e-01	-0.194000	2.94e-01
MAPK family signaling cascades	312	3.62e-09	-0.194000	4.13e-08
Plasma lipoprotein clearance	37	4.18e-02	-0.193000	8.21e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14	2.12e-01	0.193000	2.99e-01
Nuclear Receptor transcription pathway	51	1.74e-02	-0.192000	4.01e-02
Mucopolysaccharidoses	10	2.93e-01	-0.192000	3.83e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	2.51e-01	-0.191000	3.40e-01
Metabolism of nucleotides	95	1.27e-03	-0.191000	4.23e-03
FGFR4 ligand binding and activation	13	2.33e-01	-0.191000	3.21e-01
Defective GALNT12 causes CRCS1	18	1.61e-01	0.191000	2.41e-01
PIP3 activates AKT signaling	275	5.08e-08	-0.191000	4.46e-07
Acyl chain remodelling of PS	21	1.31e-01	0.191000	2.05e-01
Cell-extracellular matrix interactions	14	2.18e-01	-0.190000	3.05e-01
Interleukin-1 family signaling	134	1.46e-04	-0.190000	6.34e-04
Post-translational protein modification	1294	1.16e-30	-0.189000	1.19e-28
Macroautophagy	111	5.76e-04	-0.189000	2.14e-03
Class I MHC mediated antigen processing & presentation	363	6.61e-10	-0.188000	9.10e-09
DNA Damage Bypass	46	2.71e-02	-0.188000	5.81e-02
HSF1 activation	27	9.04e-02	-0.188000	1.53e-01
Rap1 signalling	16	1.92e-01	-0.188000	2.75e-01
Cilium Assembly	174	1.88e-05	-0.188000	1.05e-04
PCNA-Dependent Long Patch Base Excision Repair	21	1.36e-01	-0.188000	2.11e-01
SARS-CoV-2-host interactions	185	1.13e-05	-0.187000	6.63e-05
A tetrasaccharide linker sequence is required for GAG synthesis	23	1.21e-01	-0.187000	1.92e-01
Ovarian tumor domain proteases	36	5.27e-02	-0.187000	9.92e-02
Sealing of the nuclear envelope (NE) by ESCRT-III	31	7.22e-02	-0.187000	1.28e-01
Chondroitin sulfate/dermatan sulfate metabolism	45	3.04e-02	-0.186000	6.36e-02
HCMV Infection	79	4.29e-03	-0.186000	1.24e-02
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	5.37e-02	-0.186000	1.00e-01
IRF3-mediated induction of type I IFN	11	2.88e-01	-0.185000	3.77e-01
InlB-mediated entry of Listeria monocytogenes into host cell	14	2.31e-01	-0.185000	3.19e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	43	3.58e-02	0.185000	7.29e-02
Disease	1624	7.69e-36	-0.185000	9.80e-34
Interleukin-10 signaling	45	3.23e-02	0.184000	6.69e-02
Interleukin-6 family signaling	24	1.18e-01	-0.184000	1.89e-01
Translesion synthesis by POLI	17	1.88e-01	-0.184000	2.72e-01
Glutamate Neurotransmitter Release Cycle	23	1.26e-01	-0.184000	1.99e-01
Negative regulation of FGFR3 signaling	28	9.20e-02	-0.184000	1.54e-01
The phototransduction cascade	32	7.20e-02	0.184000	1.28e-01
Transport to the Golgi and subsequent modification	165	4.78e-05	-0.183000	2.34e-04
Defective C1GALT1C1 causes TNPS	18	1.79e-01	0.183000	2.61e-01
DCC mediated attractive signaling	14	2.36e-01	0.183000	3.24e-01
ALK mutants bind TKIs	12	2.73e-01	0.183000	3.62e-01
Phase 4 - resting membrane potential	19	1.68e-01	-0.182000	2.49e-01
ABC-family proteins mediated transport	98	1.80e-03	-0.182000	5.79e-03
Response of Mtb to phagocytosis	22	1.39e-01	-0.182000	2.13e-01
Signaling by NTRK2 (TRKB)	25	1.16e-01	-0.182000	1.86e-01
Thyroxine biosynthesis	10	3.20e-01	0.181000	4.10e-01
Termination of translesion DNA synthesis	31	8.04e-02	-0.181000	1.39e-01
Intracellular signaling by second messengers	313	3.89e-08	-0.180000	3.50e-07
Metal ion SLC transporters	25	1.20e-01	-0.179000	1.92e-01
ROS and RNS production in phagocytes	35	6.64e-02	-0.179000	1.19e-01
Death Receptor Signalling	129	4.59e-04	-0.178000	1.76e-03
Defective B4GALT7 causes EDS, progeroid type	17	2.03e-01	-0.178000	2.88e-01
Signaling by NODAL	22	1.48e-01	-0.178000	2.25e-01
FRS-mediated FGFR2 signaling	24	1.31e-01	-0.178000	2.05e-01
Signaling by Receptor Tyrosine Kinases	492	1.27e-11	-0.178000	2.23e-10
Gap junction degradation	10	3.30e-01	-0.178000	4.20e-01
Gap junction assembly	18	1.92e-01	0.178000	2.75e-01
E3 ubiquitin ligases ubiquitinate target proteins	43	4.39e-02	-0.178000	8.53e-02
Negative regulation of FGFR4 signaling	30	9.36e-02	-0.177000	1.56e-01
Xenobiotics	24	1.34e-01	0.177000	2.09e-01
Defective GALNT3 causes HFTC	18	1.94e-01	0.177000	2.77e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	38	5.96e-02	-0.177000	1.08e-01
Extra-nuclear estrogen signaling	73	9.10e-03	-0.176000	2.32e-02
Assembly and cell surface presentation of NMDA receptors	23	1.45e-01	-0.176000	2.21e-01
Glycogen synthesis	15	2.39e-01	-0.175000	3.28e-01
RHOBTB2 GTPase cycle	22	1.54e-01	-0.175000	2.33e-01
Transcriptional Regulation by MECP2	60	1.87e-02	-0.175000	4.28e-02
Interleukin-17 signaling	66	1.38e-02	-0.175000	3.28e-02
Signaling by FGFR3 in disease	21	1.65e-01	-0.175000	2.44e-01
FGFR1 mutant receptor activation	30	9.72e-02	-0.175000	1.61e-01
G beta:gamma signalling through CDC42	19	1.88e-01	-0.174000	2.72e-01
Autophagy	125	7.72e-04	-0.174000	2.73e-03
Constitutive Signaling by EGFRvIII	15	2.46e-01	-0.173000	3.35e-01
Signaling by EGFRvIII in Cancer	15	2.46e-01	-0.173000	3.35e-01
Integrin signaling	27	1.20e-01	-0.173000	1.92e-01
Nucleotide salvage	21	1.71e-01	-0.173000	2.51e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	1.45e-01	-0.172000	2.22e-01
Presynaptic function of Kainate receptors	21	1.73e-01	-0.172000	2.54e-01
FOXO-mediated transcription	65	1.67e-02	-0.172000	3.88e-02
Citric acid cycle (TCA cycle)	21	1.74e-01	-0.171000	2.55e-01
Downregulation of ERBB2:ERBB3 signaling	13	2.86e-01	-0.171000	3.76e-01
PI-3K cascade:FGFR1	21	1.76e-01	-0.171000	2.57e-01
Incretin synthesis, secretion, and inactivation	23	1.57e-01	-0.170000	2.36e-01
Downstream signaling of activated FGFR2	29	1.13e-01	-0.170000	1.83e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	7.01e-02	-0.170000	1.25e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	1.14e-01	-0.170000	1.85e-01
Metabolism of folate and pterines	16	2.41e-01	-0.169000	3.29e-01
SHC1 events in ERBB4 signaling	14	2.75e-01	-0.169000	3.64e-01
Paracetamol ADME	30	1.11e-01	0.168000	1.81e-01
Membrane Trafficking	586	3.24e-12	-0.168000	6.61e-11
Signaling by SCF-KIT	43	5.67e-02	-0.168000	1.05e-01
Lagging Strand Synthesis	19	2.07e-01	-0.167000	2.93e-01
Membrane binding and targetting of GAG proteins	14	2.79e-01	-0.167000	3.68e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	2.79e-01	-0.167000	3.68e-01
Regulation of PTEN mRNA translation	25	1.48e-01	0.167000	2.25e-01
FCGR3A-mediated phagocytosis	57	2.91e-02	-0.167000	6.16e-02
Leishmania phagocytosis	57	2.91e-02	-0.167000	6.16e-02
Parasite infection	57	2.91e-02	-0.167000	6.16e-02
ABC transporters in lipid homeostasis	17	2.33e-01	0.167000	3.21e-01
Intraflagellar transport	36	8.32e-02	-0.167000	1.43e-01
Apoptotic execution phase	43	5.84e-02	-0.167000	1.06e-01
Platelet calcium homeostasis	27	1.35e-01	-0.166000	2.10e-01
HSF1-dependent transactivation	35	8.89e-02	-0.166000	1.51e-01
Signaling by FGFR1 in disease	37	8.04e-02	-0.166000	1.39e-01
Molecules associated with elastic fibres	30	1.15e-01	-0.166000	1.86e-01
Regulation of MECP2 expression and activity	30	1.17e-01	-0.165000	1.87e-01
Activation of G protein gated Potassium channels	29	1.23e-01	-0.165000	1.95e-01
G protein gated Potassium channels	29	1.23e-01	-0.165000	1.95e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	29	1.23e-01	-0.165000	1.95e-01
NCAM1 interactions	36	8.66e-02	-0.165000	1.48e-01
RHOH GTPase cycle	36	8.72e-02	-0.165000	1.49e-01
FCERI mediated MAPK activation	29	1.25e-01	-0.164000	1.98e-01
NOD1/2 Signaling Pathway	29	1.26e-01	-0.164000	1.98e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	31	1.14e-01	-0.164000	1.85e-01
G beta:gamma signalling through PI3Kgamma	25	1.56e-01	-0.164000	2.34e-01
FGFR2c ligand binding and activation	12	3.26e-01	-0.164000	4.16e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	604	5.77e-12	-0.164000	1.08e-10
NR1H2 and NR1H3-mediated signaling	53	3.94e-02	0.163000	7.84e-02
Inactivation, recovery and regulation of the phototransduction cascade	31	1.15e-01	0.163000	1.86e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	2.91e-01	-0.163000	3.80e-01
Prostacyclin signalling through prostacyclin receptor	19	2.18e-01	-0.163000	3.06e-01
Growth hormone receptor signaling	24	1.67e-01	-0.163000	2.48e-01
Mitochondrial Fatty Acid Beta-Oxidation	35	9.67e-02	-0.162000	1.61e-01
Regulation of innate immune responses to cytosolic DNA	14	2.96e-01	-0.161000	3.85e-01
Cargo trafficking to the periciliary membrane	49	5.07e-02	-0.161000	9.63e-02
Adherens junctions interactions	26	1.55e-01	0.161000	2.33e-01
ADP signalling through P2Y purinoceptor 12	22	1.91e-01	-0.161000	2.74e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	2.97e-01	-0.161000	3.87e-01
IL-6-type cytokine receptor ligand interactions	17	2.51e-01	-0.161000	3.40e-01
Pre-NOTCH Processing in Golgi	18	2.38e-01	-0.160000	3.27e-01
Regulation of BACH1 activity	15	2.83e-01	-0.160000	3.73e-01
Signaling by Rho GTPases	590	3.01e-11	-0.160000	5.05e-10
Rab regulation of trafficking	114	3.20e-03	-0.160000	9.49e-03
Interleukin-12 family signaling	54	4.24e-02	-0.160000	8.30e-02
Sialic acid metabolism	33	1.12e-01	-0.160000	1.83e-01
G beta:gamma signalling through PLC beta	20	2.21e-01	-0.158000	3.09e-01
Purine catabolism	17	2.59e-01	-0.158000	3.49e-01
Fatty acids	15	2.90e-01	0.158000	3.79e-01
Peroxisomal lipid metabolism	28	1.50e-01	-0.157000	2.28e-01
Regulation of TLR by endogenous ligand	17	2.64e-01	0.156000	3.53e-01
Heparan sulfate/heparin (HS-GAG) metabolism	49	5.84e-02	-0.156000	1.06e-01
Golgi Associated Vesicle Biogenesis	51	5.38e-02	-0.156000	1.00e-01
Fanconi Anemia Pathway	37	1.02e-01	-0.155000	1.69e-01
Phospholipase C-mediated cascade; FGFR2	17	2.69e-01	-0.155000	3.58e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	2.70e-01	-0.155000	3.58e-01
Cargo concentration in the ER	32	1.30e-01	-0.154000	2.05e-01
Thromboxane signalling through TP receptor	24	1.91e-01	-0.154000	2.75e-01
Signaling by ALK fusions and activated point mutants	51	5.71e-02	-0.154000	1.05e-01
Signaling by ALK in cancer	51	5.71e-02	-0.154000	1.05e-01
Regulation of KIT signaling	16	2.88e-01	-0.153000	3.77e-01
Signaling by Non-Receptor Tyrosine Kinases	55	4.92e-02	-0.153000	9.37e-02
Signaling by PTK6	55	4.92e-02	-0.153000	9.37e-02
Metabolism	1967	8.90e-30	-0.153000	8.50e-28
Metabolic disorders of biological oxidation enzymes	32	1.35e-01	-0.153000	2.10e-01
Synthesis of IP3 and IP4 in the cytosol	25	1.88e-01	-0.152000	2.72e-01
Vitamin D (calciferol) metabolism	12	3.63e-01	-0.152000	4.54e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	10	4.07e-01	-0.151000	4.99e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	1.92e-01	-0.151000	2.75e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	6.88e-02	-0.150000	1.22e-01
PKMTs methylate histone lysines	37	1.14e-01	-0.150000	1.85e-01
C-type lectin receptors (CLRs)	137	2.42e-03	-0.150000	7.47e-03
MyD88 deficiency (TLR2/4)	16	3.00e-01	0.150000	3.88e-01
RHOV GTPase cycle	36	1.21e-01	-0.149000	1.92e-01
cGMP effects	15	3.18e-01	0.149000	4.08e-01
Negative regulation of FGFR2 signaling	33	1.39e-01	-0.149000	2.13e-01
Kinesins	42	9.51e-02	-0.149000	1.58e-01
Metabolism of vitamins and cofactors	181	5.60e-04	-0.149000	2.09e-03
Vesicle-mediated transport	624	2.32e-10	-0.148000	3.38e-09
Signaling by ERBB2 TMD/JMD mutants	21	2.40e-01	-0.148000	3.29e-01
Defective B3GAT3 causes JDSSDHD	17	2.92e-01	-0.147000	3.82e-01
Meiosis	56	5.65e-02	-0.147000	1.04e-01
Ras activation upon Ca2+ influx through NMDA receptor	19	2.66e-01	-0.147000	3.55e-01
Glycogen metabolism	24	2.14e-01	-0.146000	3.02e-01
Signaling by PDGFR in disease	20	2.58e-01	-0.146000	3.49e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	2.09e-01	-0.145000	2.95e-01
Aggrephagy	23	2.29e-01	-0.145000	3.17e-01
Depolymerisation of the Nuclear Lamina	14	3.49e-01	-0.144000	4.39e-01
Translesion synthesis by REV1	16	3.18e-01	-0.144000	4.08e-01
Signaling by Interleukins	426	3.22e-07	-0.144000	2.38e-06
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	3.53e-01	-0.143000	4.43e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	3.36e-01	-0.143000	4.25e-01
Synthesis of PIPs at the late endosome membrane	10	4.34e-01	0.143000	5.27e-01
Activation of NMDA receptors and postsynaptic events	69	4.06e-02	-0.142000	8.07e-02
Vitamin B5 (pantothenate) metabolism	16	3.24e-01	-0.142000	4.15e-01
Laminin interactions	23	2.38e-01	-0.142000	3.26e-01
Interleukin-4 and Interleukin-13 signaling	104	1.22e-02	-0.142000	2.98e-02
Signal Transduction	2408	1.04e-30	-0.142000	1.14e-28
Budding and maturation of HIV virion	28	1.94e-01	-0.142000	2.77e-01
HDL remodeling	10	4.39e-01	-0.141000	5.31e-01
Activation of GABAB receptors	43	1.09e-01	-0.141000	1.79e-01
GABA B receptor activation	43	1.09e-01	-0.141000	1.79e-01
TAK1-dependent IKK and NF-kappa-B activation	25	2.24e-01	-0.141000	3.11e-01
Aspartate and asparagine metabolism	12	4.00e-01	0.140000	4.92e-01
Signal amplification	33	1.63e-01	-0.140000	2.43e-01
Nitric oxide stimulates guanylate cyclase	22	2.55e-01	0.140000	3.45e-01
Glyoxylate metabolism and glycine degradation	30	1.84e-01	-0.140000	2.67e-01
Suppression of phagosomal maturation	13	3.83e-01	-0.140000	4.75e-01
Notch-HLH transcription pathway	24	2.36e-01	-0.140000	3.25e-01
Diseases of carbohydrate metabolism	30	1.86e-01	-0.140000	2.69e-01
Norepinephrine Neurotransmitter Release Cycle	16	3.34e-01	-0.140000	4.23e-01
activated TAK1 mediates p38 MAPK activation	16	3.34e-01	-0.140000	4.23e-01
p75 NTR receptor-mediated signalling	89	2.29e-02	-0.139000	5.05e-02
Interleukin-12 signaling	44	1.09e-01	-0.139000	1.79e-01
Intra-Golgi traffic	43	1.13e-01	-0.139000	1.85e-01
Regulation of RUNX1 Expression and Activity	25	2.28e-01	-0.139000	3.16e-01
Voltage gated Potassium channels	42	1.19e-01	-0.139000	1.90e-01
Signaling by PDGF	52	8.45e-02	-0.138000	1.45e-01
Oncogenic MAPK signaling	76	3.78e-02	-0.138000	7.61e-02
GPER1 signaling	44	1.15e-01	-0.137000	1.86e-01
PI3K events in ERBB2 signaling	16	3.43e-01	0.137000	4.32e-01
Fcgamma receptor (FCGR) dependent phagocytosis	82	3.21e-02	-0.137000	6.65e-02
Potassium Channels	102	1.71e-02	-0.137000	3.97e-02
NCAM signaling for neurite out-growth	57	7.45e-02	-0.136000	1.31e-01
Trafficking of GluR2-containing AMPA receptors	15	3.61e-01	0.136000	4.52e-01
Cytosolic sulfonation of small molecules	23	2.59e-01	0.136000	3.49e-01
Disorders of transmembrane transporters	167	2.43e-03	-0.136000	7.48e-03
Tandem pore domain potassium channels	12	4.16e-01	-0.136000	5.08e-01
Metabolism of water-soluble vitamins and cofactors	118	1.10e-02	-0.135000	2.72e-02
Ephrin signaling	17	3.34e-01	-0.135000	4.23e-01
Apoptotic cleavage of cellular proteins	35	1.66e-01	-0.135000	2.46e-01
Inwardly rectifying K+ channels	35	1.68e-01	-0.135000	2.48e-01
Metabolism of carbohydrates	275	1.27e-04	-0.134000	5.55e-04
RORA activates gene expression	17	3.39e-01	-0.134000	4.27e-01
Glycogen storage diseases	14	3.85e-01	-0.134000	4.77e-01
Signaling by Hippo	19	3.18e-01	-0.132000	4.08e-01
Mitotic Telophase/Cytokinesis	10	4.71e-01	-0.131000	5.61e-01
FCERI mediated Ca+2 mobilization	27	2.38e-01	-0.131000	3.26e-01
Activated point mutants of FGFR2	16	3.65e-01	-0.131000	4.55e-01
Peptide ligand-binding receptors	190	1.85e-03	0.131000	5.92e-03
Gene Silencing by RNA	80	4.32e-02	-0.131000	8.43e-02
G-protein beta:gamma signalling	30	2.16e-01	-0.131000	3.03e-01
Advanced glycosylation endproduct receptor signaling	13	4.18e-01	-0.130000	5.10e-01
Pentose phosphate pathway	12	4.40e-01	-0.129000	5.32e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	2.65e-01	-0.129000	3.54e-01
Developmental Biology	1020	3.39e-12	-0.128000	6.82e-11
Listeria monocytogenes entry into host cells	19	3.34e-01	-0.128000	4.23e-01
Amyloid fiber formation	53	1.08e-01	-0.128000	1.77e-01
mTORC1-mediated signalling	23	2.89e-01	-0.128000	3.79e-01
Signaling by FGFR4 in disease	11	4.65e-01	-0.127000	5.55e-01
Peptide hormone biosynthesis	11	4.67e-01	0.127000	5.56e-01
Detoxification of Reactive Oxygen Species	35	1.96e-01	-0.126000	2.80e-01
Activation of kainate receptors upon glutamate binding	29	2.41e-01	-0.126000	3.29e-01
CS/DS degradation	12	4.54e-01	-0.125000	5.46e-01
Neutrophil degranulation	458	5.19e-06	-0.124000	3.24e-05
Trafficking and processing of endosomal TLR	11	4.77e-01	-0.124000	5.66e-01
Reduction of cytosolic Ca++ levels	11	4.80e-01	-0.123000	5.68e-01
Metabolism of steroid hormones	33	2.22e-01	0.123000	3.10e-01
Translesion synthesis by POLK	17	3.82e-01	-0.122000	4.75e-01
Dopamine Neurotransmitter Release Cycle	20	3.49e-01	-0.121000	4.39e-01
Post NMDA receptor activation events	58	1.11e-01	-0.121000	1.81e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	2.23e-01	-0.121000	3.11e-01
Diseases associated with visual transduction	11	4.89e-01	0.120000	5.75e-01
Diseases of the neuronal system	11	4.89e-01	0.120000	5.75e-01
Retinoid cycle disease events	11	4.89e-01	0.120000	5.75e-01
Dermatan sulfate biosynthesis	10	5.12e-01	-0.120000	5.93e-01
Meiotic synapsis	32	2.43e-01	-0.119000	3.31e-01
Signaling by Insulin receptor	76	7.29e-02	-0.119000	1.29e-01
Regulation of IFNA/IFNB signaling	24	3.19e-01	0.118000	4.08e-01
Signaling by EGFR in Cancer	25	3.11e-01	-0.117000	4.00e-01
CLEC7A (Dectin-1) induces NFAT activation	11	5.02e-01	-0.117000	5.85e-01
Visual phototransduction	93	5.24e-02	0.116000	9.90e-02
Interaction between L1 and Ankyrins	28	2.87e-01	0.116000	3.76e-01
Pre-NOTCH Expression and Processing	61	1.16e-01	-0.116000	1.87e-01
RND3 GTPase cycle	41	1.98e-01	-0.116000	2.82e-01
Cytokine Signaling in Immune system	667	3.02e-07	-0.116000	2.26e-06
CaM pathway	33	2.50e-01	-0.116000	3.40e-01
Calmodulin induced events	33	2.50e-01	-0.116000	3.40e-01
MET receptor recycling	10	5.27e-01	-0.115000	6.07e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	29	2.82e-01	0.115000	3.72e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77	8.04e-02	-0.115000	1.39e-01
Chaperone Mediated Autophagy	19	3.85e-01	-0.115000	4.77e-01
Synthesis of PIPs at the early endosome membrane	15	4.43e-01	0.114000	5.35e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	42	2.00e-01	-0.114000	2.84e-01
Nicotinamide salvaging	17	4.15e-01	-0.114000	5.07e-01
Signaling by EGFR	49	1.69e-01	-0.113000	2.49e-01
Diseases of metabolism	234	3.01e-03	-0.112000	9.02e-03
Glycerophospholipid biosynthesis	114	3.85e-02	-0.112000	7.74e-02
Nucleotide-like (purinergic) receptors	13	4.84e-01	0.112000	5.71e-01
Beta-oxidation of very long chain fatty acids	10	5.40e-01	-0.112000	6.21e-01
Eicosanoids	12	5.03e-01	0.112000	5.85e-01
RHO GTPase cycle	421	8.51e-05	-0.111000	3.94e-04
Signaling by ERBB2 in Cancer	25	3.35e-01	-0.111000	4.24e-01
Uptake and actions of bacterial toxins	29	3.01e-01	-0.111000	3.90e-01
EGFR downregulation	30	2.94e-01	-0.111000	3.83e-01
Sphingolipid metabolism	81	8.62e-02	-0.110000	1.48e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	5.09e-01	-0.110000	5.91e-01
Defective EXT2 causes exostoses 2	12	5.09e-01	-0.110000	5.91e-01
Ca2+ pathway	62	1.34e-01	-0.110000	2.09e-01
PKA activation	18	4.20e-01	-0.110000	5.12e-01
Effects of PIP2 hydrolysis	26	3.35e-01	-0.109000	4.24e-01
Triglyceride catabolism	23	3.64e-01	-0.109000	4.55e-01
CRMPs in Sema3A signaling	15	4.64e-01	-0.109000	5.54e-01
Eicosanoid ligand-binding receptors	14	4.80e-01	-0.109000	5.68e-01
Translesion Synthesis by POLH	19	4.13e-01	-0.108000	5.05e-01
Signaling by ERBB4	57	1.56e-01	-0.108000	2.35e-01
Signaling by ERBB2	49	1.90e-01	-0.108000	2.73e-01
Adaptive Immune System	711	9.08e-07	-0.108000	6.28e-06
Cardiac conduction	120	4.14e-02	-0.108000	8.14e-02
DAP12 signaling	28	3.24e-01	-0.108000	4.15e-01
RA biosynthesis pathway	22	3.86e-01	-0.107000	4.77e-01
Triglyceride metabolism	36	2.68e-01	-0.107000	3.57e-01
Hyaluronan metabolism	17	4.46e-01	-0.107000	5.38e-01
Phase 0 - rapid depolarisation	31	3.05e-01	-0.106000	3.94e-01
Cell-cell junction organization	56	1.69e-01	0.106000	2.49e-01
GPVI-mediated activation cascade	32	2.98e-01	-0.106000	3.87e-01
Pyrimidine catabolism	12	5.25e-01	0.106000	6.06e-01
Signaling by VEGF	101	6.66e-02	-0.106000	1.19e-01
Signaling by MET	66	1.38e-01	-0.105000	2.13e-01
RHOF GTPase cycle	40	2.49e-01	-0.105000	3.38e-01
IRAK4 deficiency (TLR2/4)	17	4.53e-01	0.105000	5.45e-01
E2F mediated regulation of DNA replication	20	4.21e-01	-0.104000	5.13e-01
Tryptophan catabolism	12	5.34e-01	0.104000	6.15e-01
Platelet Aggregation (Plug Formation)	37	2.76e-01	-0.103000	3.66e-01
Phospholipid metabolism	192	1.35e-02	-0.103000	3.23e-02
Signaling by cytosolic FGFR1 fusion mutants	17	4.62e-01	-0.103000	5.53e-01
VEGFA-VEGFR2 Pathway	93	8.63e-02	-0.103000	1.48e-01
G alpha (i) signalling events	306	1.97e-03	0.103000	6.24e-03
Triglyceride biosynthesis	13	5.24e-01	-0.102000	6.05e-01
Binding and Uptake of Ligands by Scavenger Receptors	41	2.58e-01	0.102000	3.49e-01
GAB1 signalosome	17	4.66e-01	0.102000	5.55e-01
Nucleotide catabolism	35	2.98e-01	-0.102000	3.87e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	2.60e-01	-0.102000	3.49e-01
Signaling by RAS mutants	41	2.60e-01	-0.102000	3.49e-01
Signaling by moderate kinase activity BRAF mutants	41	2.60e-01	-0.102000	3.49e-01
Signaling downstream of RAS mutants	41	2.60e-01	-0.102000	3.49e-01
MHC class II antigen presentation	104	7.42e-02	-0.101000	1.30e-01
Neuronal System	371	8.01e-04	-0.101000	2.81e-03
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	20	4.34e-01	-0.101000	5.27e-01
ADP signalling through P2Y purinoceptor 1	25	3.82e-01	-0.101000	4.74e-01
The NLRP3 inflammasome	16	4.84e-01	-0.101000	5.71e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	104	7.71e-02	-0.100000	1.35e-01
Cell death signalling via NRAGE, NRIF and NADE	69	1.51e-01	-0.100000	2.28e-01
Nuclear signaling by ERBB4	32	3.28e-01	-0.099900	4.17e-01
COPI-independent Golgi-to-ER retrograde traffic	34	3.13e-01	-0.099900	4.03e-01
Fatty acyl-CoA biosynthesis	35	3.10e-01	-0.099000	4.00e-01
Regulation of localization of FOXO transcription factors	11	5.70e-01	0.098900	6.51e-01
Transmission across Chemical Synapses	237	8.81e-03	-0.098700	2.25e-02
Class A/1 (Rhodopsin-like receptors)	312	2.75e-03	0.098500	8.34e-03
Semaphorin interactions	61	1.85e-01	-0.098100	2.68e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	23	4.15e-01	-0.098100	5.08e-01
Signaling by ERBB2 KD Mutants	24	4.07e-01	-0.097800	4.99e-01
Serotonin Neurotransmitter Release Cycle	16	4.99e-01	-0.097600	5.84e-01
FGFR2b ligand binding and activation	10	5.94e-01	0.097400	6.71e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	5.96e-01	0.096800	6.73e-01
HS-GAG biosynthesis	28	3.75e-01	-0.096700	4.68e-01
Fatty acid metabolism	167	3.10e-02	-0.096600	6.47e-02
Apoptotic cleavage of cell adhesion proteins	11	5.80e-01	0.096300	6.60e-01
Vasopressin regulates renal water homeostasis via Aquaporins	42	2.81e-01	-0.096100	3.70e-01
PI Metabolism	79	1.40e-01	-0.096100	2.14e-01
Collagen degradation	39	2.99e-01	0.096000	3.88e-01
Platelet homeostasis	85	1.27e-01	-0.095800	1.99e-01
G alpha (z) signalling events	48	2.53e-01	-0.095400	3.42e-01
Non-integrin membrane-ECM interactions	40	2.99e-01	-0.094900	3.88e-01
DAG and IP3 signaling	39	3.07e-01	-0.094500	3.96e-01
RAB GEFs exchange GTP for GDP on RABs	83	1.37e-01	-0.094500	2.11e-01
Presynaptic depolarization and calcium channel opening	12	5.71e-01	-0.094400	6.52e-01
Erythrocytes take up carbon dioxide and release oxygen	12	5.73e-01	-0.094000	6.53e-01
O2/CO2 exchange in erythrocytes	12	5.73e-01	-0.094000	6.53e-01
Chylomicron remodeling	10	6.07e-01	-0.094000	6.82e-01
RND1 GTPase cycle	41	2.98e-01	-0.093900	3.87e-01
Opioid Signalling	88	1.28e-01	-0.093800	2.02e-01
FGFR2 ligand binding and activation	19	4.79e-01	-0.093700	5.68e-01
Na+/Cl- dependent neurotransmitter transporters	18	4.91e-01	0.093700	5.77e-01
Plasma lipoprotein assembly, remodeling, and clearance	73	1.73e-01	-0.092100	2.54e-01
PKA-mediated phosphorylation of CREB	19	4.87e-01	-0.092100	5.74e-01
Pre-NOTCH Transcription and Translation	45	2.85e-01	-0.092000	3.76e-01
MET activates PTK2 signaling	18	5.02e-01	0.091400	5.85e-01
Metabolism of amine-derived hormones	17	5.15e-01	0.091300	5.96e-01
PI-3K cascade:FGFR3	17	5.17e-01	-0.090800	5.97e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	4.82e-01	-0.090800	5.70e-01
Organic cation transport	10	6.20e-01	-0.090600	6.95e-01
Adenylate cyclase inhibitory pathway	14	5.58e-01	-0.090400	6.39e-01
Glycosaminoglycan metabolism	116	9.37e-02	-0.090000	1.56e-01
RHOD GTPase cycle	49	2.76e-01	-0.090000	3.65e-01
PI3K events in ERBB4 signaling	10	6.23e-01	0.089700	6.96e-01
PI-3K cascade:FGFR4	19	5.00e-01	-0.089400	5.84e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	5.51e-01	0.088800	6.32e-01
Myogenesis	29	4.10e-01	0.088400	5.02e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	20	4.95e-01	-0.088100	5.81e-01
Tie2 Signaling	18	5.19e-01	-0.087800	5.99e-01
Scavenging by Class A Receptors	19	5.08e-01	0.087700	5.91e-01
Metabolism of lipids	696	8.44e-05	-0.087200	3.92e-04
Keratan sulfate biosynthesis	28	4.25e-01	0.087100	5.17e-01
Inflammasomes	21	4.92e-01	-0.086700	5.77e-01
Biosynthesis of DHA-derived SPMs	17	5.37e-01	-0.086500	6.18e-01
GABA receptor activation	57	2.58e-01	-0.086500	3.49e-01
Thrombin signalling through proteinase activated receptors (PARs)	32	3.99e-01	-0.086100	4.91e-01
Glucagon-type ligand receptors	33	3.92e-01	-0.086000	4.83e-01
Hyaluronan uptake and degradation	12	6.06e-01	-0.086000	6.81e-01
Integration of energy metabolism	106	1.27e-01	-0.085800	1.99e-01
The role of Nef in HIV-1 replication and disease pathogenesis	27	4.41e-01	0.085700	5.33e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	4.34e-01	0.085400	5.27e-01
Integrin cell surface interactions	66	2.31e-01	-0.085200	3.20e-01
Diseases of glycosylation	137	8.61e-02	-0.084900	1.48e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	6.32e-01	-0.083300	7.03e-01
Negative regulation of the PI3K/AKT network	111	1.30e-01	-0.083000	2.05e-01
RAC3 GTPase cycle	84	1.89e-01	-0.082800	2.72e-01
Regulation of signaling by NODAL	11	6.36e-01	-0.082300	7.07e-01
Frs2-mediated activation	12	6.23e-01	-0.081900	6.96e-01
Synthesis of PIPs at the Golgi membrane	17	5.61e-01	0.081400	6.42e-01
Interferon alpha/beta signaling	71	2.37e-01	-0.081200	3.25e-01
Lysine catabolism	12	6.29e-01	0.080500	7.00e-01
Ion homeostasis	50	3.25e-01	-0.080400	4.15e-01
Interferon Signaling	194	5.40e-02	-0.080100	1.01e-01
Azathioprine ADME	22	5.15e-01	-0.080100	5.96e-01
PECAM1 interactions	12	6.32e-01	0.079900	7.02e-01
Other semaphorin interactions	18	5.58e-01	0.079800	6.39e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	52	3.22e-01	-0.079400	4.12e-01
Dissolution of Fibrin Clot	13	6.20e-01	0.079300	6.95e-01
Smooth Muscle Contraction	39	3.99e-01	-0.078000	4.91e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	3.88e-01	-0.077900	4.80e-01
Chylomicron assembly	10	6.70e-01	-0.077700	7.39e-01
STING mediated induction of host immune responses	13	6.28e-01	-0.077600	7.00e-01
Prolactin receptor signaling	15	6.04e-01	-0.077400	6.80e-01
PI3K/AKT Signaling in Cancer	103	1.75e-01	-0.077200	2.57e-01
Interleukin-2 family signaling	40	4.05e-01	-0.076100	4.97e-01
Translocation of ZAP-70 to Immunological synapse	17	5.87e-01	0.076000	6.66e-01
Regulation of lipid metabolism by PPARalpha	116	1.59e-01	-0.075700	2.38e-01
Chondroitin sulfate biosynthesis	18	5.80e-01	-0.075400	6.59e-01
IGF1R signaling cascade	51	3.57e-01	-0.074600	4.47e-01
Activation of RAC1	11	6.69e-01	0.074500	7.38e-01
Acyl chain remodelling of PC	26	5.12e-01	0.074300	5.93e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	6.19e-01	-0.074000	6.95e-01
Metabolism of fat-soluble vitamins	46	3.89e-01	-0.073400	4.81e-01
Sensory processing of sound by inner hair cells of the cochlea	62	3.18e-01	-0.073300	4.08e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	112	1.81e-01	-0.073200	2.63e-01
RAC2 GTPase cycle	80	2.59e-01	-0.072900	3.49e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	13	6.51e-01	-0.072400	7.22e-01
Ca-dependent events	35	4.59e-01	-0.072300	5.50e-01
Aquaporin-mediated transport	51	3.72e-01	-0.072200	4.64e-01
Miscellaneous substrates	12	6.65e-01	0.072200	7.34e-01
Unblocking of NMDA receptors, glutamate binding and activation	19	5.86e-01	-0.072100	6.65e-01
Phase 2 - plateau phase	14	6.41e-01	-0.071900	7.12e-01
Amino acid transport across the plasma membrane	30	4.97e-01	-0.071600	5.82e-01
Transport of vitamins, nucleosides, and related molecules	38	4.45e-01	0.071500	5.37e-01
Immune System	1877	2.50e-07	-0.071300	1.91e-06
ECM proteoglycans	55	3.66e-01	0.070400	4.57e-01
Protein-protein interactions at synapses	78	2.87e-01	-0.069700	3.76e-01
Carboxyterminal post-translational modifications of tubulin	40	4.53e-01	-0.068600	5.45e-01
Innate Immune System	999	2.30e-04	-0.068600	9.36e-04
Neurotransmitter receptors and postsynaptic signal transmission	175	1.18e-01	-0.068500	1.89e-01
Insulin receptor signalling cascade	53	3.92e-01	-0.068000	4.83e-01
Termination of O-glycan biosynthesis	25	5.57e-01	0.067900	6.38e-01
Glucagon signaling in metabolic regulation	33	5.00e-01	-0.067800	5.84e-01
Signal regulatory protein family interactions	13	6.75e-01	-0.067200	7.43e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	7.00e-01	-0.067000	7.67e-01
Muscle contraction	186	1.15e-01	-0.067000	1.86e-01
CD209 (DC-SIGN) signaling	20	6.04e-01	0.066900	6.80e-01
Inositol phosphate metabolism	45	4.38e-01	-0.066800	5.31e-01
Stimuli-sensing channels	96	2.59e-01	0.066600	3.49e-01
RHOC GTPase cycle	69	3.40e-01	-0.066400	4.28e-01
Plasma lipoprotein assembly	19	6.18e-01	0.066000	6.94e-01
O-linked glycosylation of mucins	62	3.70e-01	0.065800	4.62e-01
PPARA activates gene expression	114	2.26e-01	-0.065700	3.13e-01
VEGFR2 mediated vascular permeability	26	5.64e-01	0.065400	6.44e-01
Collagen chain trimerization	42	4.65e-01	0.065100	5.55e-01
p130Cas linkage to MAPK signaling for integrins	15	6.63e-01	0.065000	7.33e-01
Biosynthesis of specialized proresolving mediators (SPMs)	19	6.24e-01	-0.064900	6.97e-01
Reactions specific to the complex N-glycan synthesis pathway	10	7.25e-01	0.064200	7.88e-01
Heme signaling	45	4.57e-01	-0.064000	5.49e-01
Platelet activation, signaling and aggregation	246	8.53e-02	-0.063600	1.46e-01
Transport of small molecules	689	4.52e-03	-0.063300	1.28e-02
IRS-mediated signalling	47	4.58e-01	-0.062600	5.49e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	7.08e-01	-0.062400	7.74e-01
Presynaptic nicotinic acetylcholine receptors	12	7.10e-01	-0.062000	7.75e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	6.68e-01	-0.061900	7.37e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	6.70e-01	-0.061500	7.39e-01
Serotonin receptors	11	7.24e-01	0.061400	7.88e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	7.13e-01	-0.061300	7.78e-01
Regulation of insulin secretion	77	3.55e-01	-0.060900	4.45e-01
Downregulation of ERBB2 signaling	28	5.77e-01	-0.060900	6.57e-01
RND2 GTPase cycle	42	5.00e-01	-0.060100	5.84e-01
PI-3K cascade:FGFR2	22	6.29e-01	-0.059500	7.00e-01
Phase I - Functionalization of compounds	100	3.05e-01	0.059300	3.94e-01
Role of phospholipids in phagocytosis	23	6.23e-01	-0.059200	6.96e-01
RHOA GTPase cycle	140	2.27e-01	-0.059100	3.15e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	120	2.69e-01	0.058300	3.58e-01
IRS-related events triggered by IGF1R	50	4.76e-01	-0.058300	5.65e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	11	7.39e-01	-0.058100	7.99e-01
Tight junction interactions	28	6.01e-01	0.057000	6.78e-01
GPCR downstream signalling	604	1.72e-02	0.056600	4.00e-02
MECP2 regulates neuronal receptors and channels	17	6.86e-01	-0.056600	7.53e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	7.25e-01	-0.056300	7.88e-01
Costimulation by the CD28 family	65	4.35e-01	-0.056000	5.27e-01
Nicotinate metabolism	29	6.02e-01	-0.056000	6.78e-01
Hemostasis	560	2.49e-02	-0.055300	5.43e-02
Insulin processing	26	6.27e-01	-0.055100	6.99e-01
SHC1 events in ERBB2 signaling	22	6.55e-01	-0.055000	7.25e-01
GPCR ligand binding	444	4.83e-02	0.054600	9.29e-02
Late endosomal microautophagy	32	5.95e-01	-0.054200	6.73e-01
Carnitine metabolism	11	7.59e-01	-0.053500	8.18e-01
Sensory processing of sound	69	4.44e-01	-0.053300	5.36e-01
CYP2E1 reactions	11	7.63e-01	0.052500	8.21e-01
Interleukin-37 signaling	21	6.77e-01	-0.052400	7.45e-01
Metalloprotease DUBs	19	6.93e-01	-0.052300	7.60e-01
Cytochrome P450 - arranged by substrate type	64	4.83e-01	0.050700	5.70e-01
Synthesis of PIPs at the plasma membrane	48	5.45e-01	-0.050500	6.26e-01
Signaling by BRAF and RAF1 fusions	60	5.06e-01	-0.049600	5.89e-01
Phosphorylation of CD3 and TCR zeta chains	20	7.02e-01	0.049400	7.69e-01
G alpha (12/13) signalling events	74	4.64e-01	-0.049300	5.54e-01
O-linked glycosylation	107	3.82e-01	0.048900	4.74e-01
Factors involved in megakaryocyte development and platelet production	130	3.37e-01	-0.048700	4.25e-01
DSCAM interactions	11	7.80e-01	-0.048600	8.36e-01
SLC transporter disorders	92	4.23e-01	-0.048300	5.15e-01
Prolonged ERK activation events	14	7.55e-01	-0.048200	8.14e-01
Phenylalanine and tyrosine metabolism	10	7.92e-01	-0.048100	8.46e-01
Phase II - Conjugation of compounds	109	3.90e-01	0.047600	4.81e-01
Gap junction trafficking and regulation	29	6.63e-01	0.046800	7.33e-01
TRAF6 mediated IRF7 activation	28	6.72e-01	0.046200	7.40e-01
Assembly of collagen fibrils and other multimeric structures	56	5.50e-01	-0.046200	6.31e-01
Pregnenolone biosynthesis	10	8.02e-01	-0.045700	8.54e-01
Negative regulation of MET activity	20	7.24e-01	-0.045500	7.88e-01
Cellular hexose transport	21	7.19e-01	0.045400	7.84e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	7.27e-01	-0.045100	7.89e-01
Amine ligand-binding receptors	41	6.21e-01	-0.044600	6.95e-01
Gap junction trafficking	27	6.88e-01	0.044600	7.55e-01
G alpha (q) signalling events	206	2.80e-01	0.043600	3.70e-01
Constitutive Signaling by Aberrant PI3K in Cancer	77	5.08e-01	-0.043600	5.91e-01
L1CAM interactions	92	4.75e-01	-0.043100	5.64e-01
CD28 dependent Vav1 pathway	11	8.09e-01	-0.042100	8.58e-01
Metabolism of steroids	148	3.81e-01	-0.041600	4.74e-01
Long-term potentiation	22	7.36e-01	-0.041400	7.98e-01
Sodium/Calcium exchangers	11	8.13e-01	0.041100	8.61e-01
Degradation of the extracellular matrix	108	4.62e-01	0.040900	5.53e-01
PD-1 signaling	21	7.51e-01	0.040000	8.11e-01
Assembly of the ORC complex at the origin of replication	10	8.26e-01	0.040000	8.73e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	101	4.98e-01	-0.039000	5.83e-01
Biological oxidations	216	3.27e-01	0.038700	4.17e-01
Adenylate cyclase activating pathway	10	8.34e-01	-0.038200	8.77e-01
Acyl chain remodelling of PE	24	7.48e-01	0.037800	8.09e-01
ADORA2B mediated anti-inflammatory cytokines production	132	4.55e-01	0.037700	5.46e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	117	4.83e-01	0.037500	5.71e-01
Cell surface interactions at the vascular wall	129	4.63e-01	-0.037400	5.54e-01
Synthesis of PA	35	7.03e-01	0.037200	7.69e-01
Acetylcholine binding and downstream events	14	8.11e-01	-0.036900	8.59e-01
Postsynaptic nicotinic acetylcholine receptors	14	8.11e-01	-0.036900	8.59e-01
MET promotes cell motility	29	7.32e-01	0.036700	7.94e-01
Aflatoxin activation and detoxification	20	7.77e-01	-0.036600	8.33e-01
Assembly of active LPL and LIPC lipase complexes	17	7.94e-01	0.036500	8.47e-01
Neurexins and neuroligins	52	6.48e-01	-0.036500	7.19e-01
RHOG GTPase cycle	69	6.00e-01	-0.036500	6.77e-01
Cell junction organization	79	5.83e-01	0.035700	6.62e-01
Leishmania infection	245	3.36e-01	-0.035600	4.25e-01
Synthesis of very long-chain fatty acyl-CoAs	23	7.71e-01	0.035100	8.29e-01
CD28 dependent PI3K/Akt signaling	22	7.76e-01	-0.035000	8.33e-01
CD28 co-stimulation	32	7.37e-01	-0.034300	7.98e-01
GRB2 events in EGFR signaling	13	8.34e-01	0.033700	8.77e-01
Interleukin-20 family signaling	25	7.73e-01	-0.033400	8.30e-01
PIWI-interacting RNA (piRNA) biogenesis	29	7.63e-01	0.032400	8.21e-01
CTLA4 inhibitory signaling	21	7.98e-01	-0.032300	8.51e-01
Interleukin receptor SHC signaling	24	7.84e-01	-0.032300	8.39e-01
SHC1 events in EGFR signaling	14	8.35e-01	-0.032200	8.77e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21	7.99e-01	0.032100	8.51e-01
Alpha-protein kinase 1 signaling pathway	10	8.63e-01	0.031400	8.99e-01
Signal transduction by L1	20	8.08e-01	-0.031400	8.57e-01
TRP channels	24	7.90e-01	-0.031300	8.45e-01
Role of LAT2/NTAL/LAB on calcium mobilization	13	8.46e-01	0.031000	8.88e-01
PI3K Cascade	43	7.26e-01	-0.030900	7.88e-01
FCGR activation	12	8.54e-01	0.030700	8.92e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	16	8.32e-01	0.030700	8.76e-01
RHO GTPases activate IQGAPs	11	8.67e-01	0.029200	9.01e-01
MAP2K and MAPK activation	36	7.64e-01	-0.028900	8.22e-01
NOTCH2 intracellular domain regulates transcription	11	8.69e-01	-0.028700	9.03e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	8.53e-01	-0.028700	8.92e-01
G-protein mediated events	52	7.23e-01	-0.028400	7.88e-01
Sensory processing of sound by outer hair cells of the cochlea	49	7.32e-01	-0.028200	7.94e-01
VxPx cargo-targeting to cilium	20	8.29e-01	0.027900	8.75e-01
Organic cation/anion/zwitterion transport	15	8.55e-01	-0.027200	8.93e-01
RHO GTPases Activate NADPH Oxidases	22	8.37e-01	-0.025300	8.79e-01
Collagen formation	88	6.85e-01	-0.025000	7.53e-01
Gastrin-CREB signalling pathway via PKC and MAPK	17	8.61e-01	0.024500	8.98e-01
Anti-inflammatory response favouring Leishmania parasite infection	164	5.91e-01	0.024300	6.69e-01
Leishmania parasite growth and survival	164	5.91e-01	0.024300	6.69e-01
RAC1 GTPase cycle	170	5.88e-01	-0.024100	6.66e-01
Signaling by RAF1 mutants	37	8.06e-01	-0.023300	8.57e-01
Organic anion transporters	10	9.00e-01	0.023000	9.26e-01
MET activates RAP1 and RAC1	11	8.96e-01	0.022800	9.23e-01
Bicarbonate transporters	10	9.02e-01	0.022400	9.27e-01
Defective B3GALTL causes PpS	36	8.16e-01	-0.022300	8.63e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	15	8.81e-01	0.022200	9.12e-01
Netrin-1 signaling	49	7.92e-01	0.021800	8.46e-01
Signaling by GPCR	671	3.40e-01	0.021500	4.28e-01
Regulation of signaling by CBL	18	8.74e-01	-0.021500	9.07e-01
Pyroptosis	26	8.49e-01	0.021500	8.91e-01
RHO GTPases activate PAKs	19	8.74e-01	-0.021100	9.07e-01
Diseases associated with glycosaminoglycan metabolism	38	8.30e-01	-0.020100	8.75e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	8.51e-01	-0.020100	8.92e-01
Trafficking of AMPA receptors	29	8.51e-01	-0.020100	8.92e-01
DAP12 interactions	40	8.31e-01	-0.019500	8.75e-01
Surfactant metabolism	29	8.60e-01	0.018900	8.97e-01
Blood group systems biosynthesis	22	8.79e-01	0.018800	9.10e-01
NRAGE signals death through JNK	53	8.18e-01	0.018300	8.64e-01
GRB2 events in ERBB2 signaling	16	9.05e-01	-0.017300	9.28e-01
Diseases associated with O-glycosylation of proteins	66	8.08e-01	0.017300	8.57e-01
TNFs bind their physiological receptors	25	8.84e-01	-0.016900	9.13e-01
N-glycan antennae elongation in the medial/trans-Golgi	26	8.84e-01	0.016600	9.13e-01
Recycling pathway of L1	23	8.94e-01	-0.016000	9.21e-01
O-glycosylation of TSR domain-containing proteins	37	8.67e-01	-0.015900	9.01e-01
Cell-Cell communication	112	7.73e-01	0.015800	8.30e-01
Lewis blood group biosynthesis	18	9.10e-01	-0.015400	9.31e-01
Endogenous sterols	26	8.94e-01	0.015100	9.21e-01
Pyrimidine salvage	10	9.37e-01	-0.014500	9.56e-01
Ion transport by P-type ATPases	51	8.60e-01	-0.014300	8.97e-01
Generation of second messenger molecules	30	8.93e-01	0.014200	9.21e-01
Sphingolipid de novo biosynthesis	41	8.77e-01	-0.013900	9.09e-01
Metabolism of porphyrins	27	9.02e-01	0.013700	9.27e-01
Sema3A PAK dependent Axon repulsion	14	9.30e-01	0.013600	9.50e-01
CDC42 GTPase cycle	144	7.83e-01	-0.013300	8.39e-01
RHOB GTPase cycle	66	8.53e-01	-0.013200	8.92e-01
Arachidonic acid metabolism	56	8.66e-01	-0.013100	9.01e-01
Platelet degranulation	116	8.08e-01	0.013000	8.57e-01
RHOQ GTPase cycle	57	8.78e-01	-0.011800	9.09e-01
Keratan sulfate/keratin metabolism	33	9.09e-01	0.011600	9.31e-01
Ion channel transport	168	8.08e-01	0.010900	8.57e-01
Collagen biosynthesis and modifying enzymes	65	8.93e-01	0.009620	9.21e-01
Nephrin family interactions	21	9.39e-01	-0.009590	9.57e-01
RHOU GTPase cycle	37	9.23e-01	-0.009230	9.44e-01
Ketone body metabolism	10	9.61e-01	-0.008850	9.73e-01
Acyl chain remodelling of PG	18	9.51e-01	0.008390	9.67e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	9.59e-01	0.008310	9.72e-01
Passive transport by Aquaporins	13	9.59e-01	0.008260	9.72e-01
ERBB2 Regulates Cell Motility	15	9.58e-01	0.007940	9.72e-01
Peptide hormone metabolism	83	9.07e-01	0.007450	9.30e-01
Transport of bile salts and organic acids, metal ions and amine compounds	84	9.09e-01	0.007200	9.31e-01
RHOJ GTPase cycle	51	9.35e-01	-0.006600	9.54e-01
Signaling by high-kinase activity BRAF mutants	32	9.49e-01	-0.006570	9.66e-01
Signaling by BMP	27	9.54e-01	-0.006380	9.69e-01
Retinoid metabolism and transport	42	9.45e-01	-0.006170	9.62e-01
Striated Muscle Contraction	33	9.53e-01	-0.005980	9.68e-01
Post-translational protein phosphorylation	100	9.23e-01	0.005580	9.44e-01
Extracellular matrix organization	288	9.01e-01	0.004250	9.27e-01
N-Glycan antennae elongation	15	9.78e-01	-0.004020	9.86e-01
Cell recruitment (pro-inflammatory response)	25	9.74e-01	-0.003790	9.82e-01
Purinergic signaling in leishmaniasis infection	25	9.74e-01	-0.003790	9.82e-01
PKA activation in glucagon signalling	17	9.78e-01	-0.003780	9.86e-01
Post-translational modification: synthesis of GPI-anchored proteins	90	9.60e-01	0.003040	9.72e-01
Response to elevated platelet cytosolic Ca2+	121	9.56e-01	0.002930	9.70e-01
Interferon gamma signaling	90	9.64e-01	-0.002750	9.75e-01
G-protein activation	24	9.82e-01	-0.002610	9.87e-01
Diseases associated with the TLR signaling cascade	29	9.82e-01	0.002430	9.87e-01
Diseases of Immune System	29	9.82e-01	0.002430	9.87e-01
EPHA-mediated growth cone collapse	15	9.87e-01	-0.002420	9.91e-01
Regulation of commissural axon pathfinding by SLIT and ROBO	10	9.91e-01	-0.001950	9.94e-01
Plasma lipoprotein remodeling	32	9.86e-01	-0.001850	9.90e-01
G alpha (s) signalling events	153	9.73e-01	0.001610	9.82e-01
SLC-mediated transmembrane transport	238	9.72e-01	0.001320	9.82e-01
FCGR3A-mediated IL10 synthesis	37	9.90e-01	-0.001210	9.93e-01
PLC beta mediated events	47	9.92e-01	0.000824	9.94e-01
Receptor-type tyrosine-protein phosphatases	16	9.96e-01	-0.000799	9.96e-01
Reproduction	82	9.94e-01	-0.000510	9.95e-01
Acyl chain remodelling of PI	16	9.99e-01	0.000165	9.99e-01

---

Detailed Gene set reports

RUNX3 regulates p14-ARF

RUNX3 regulates p14-ARF

	1052
set	RUNX3 regulates p14-ARF
setSize	10
pANOVA	0.000258
s.dist	-0.667
p.adjustANOVA	0.00104

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BRD2	-18564
KRAS	-18405
CCND1	-17934
RUNX3	-16698
CDKN2A	-15805
TGFB1	-15355
CBFB	-14689
RUNX1	-11096
EP300	-7133
HDAC4	-6590

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BRD2	-18564
KRAS	-18405
CCND1	-17934
RUNX3	-16698
CDKN2A	-15805
TGFB1	-15355
CBFB	-14689
RUNX1	-11096
EP300	-7133
HDAC4	-6590

---

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

	884
set	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
setSize	10
pANOVA	0.000797
s.dist	-0.612
p.adjustANOVA	0.0028

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDX2	-18427
TSC22D1	-18189
SOX2	-18095
HHEX	-18035
EOMES	-17860
GSC	-17616
DKK1	-14786
GATA6	-11630
POU5F1	-7886
NANOG	7413

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDX2	-18427
TSC22D1	-18189
SOX2	-18095
HHEX	-18035
EOMES	-17860
GSC	-17616
DKK1	-14786
GATA6	-11630
POU5F1	-7886
NANOG	7413

---

Digestion of dietary carbohydrate

Digestion of dietary carbohydrate

	318
set	Digestion of dietary carbohydrate
setSize	10
pANOVA	0.000798
s.dist	0.612
p.adjustANOVA	0.0028

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CHIA	6960
MGAM	6845
AMY1B	5912
AMY1C	5912
AMY1A	5912
AMY2A	5724
LCT	3221
CHIT1	-2792
TREH	-5501
AMY2B	-7279

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CHIA	6960
MGAM	6845
AMY1B	5912
AMY1C	5912
AMY1A	5912
AMY2A	5724
LCT	3221
CHIT1	-2792
TREH	-5501
AMY2B	-7279

---

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

	1364
set	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
setSize	14
pANOVA	1e-04
s.dist	-0.6
p.adjustANOVA	0.000451

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1B	-18553
TP53	-18115
E2F8	-18090
CCNA1	-15733
ZNF385A	-15144
CCNE1	-14745
CCNA2	-14537
CCNE2	-13663
PCBP4	-13158
CDKN1A	-12698
E2F1	-11507
ARID3A	-10892
E2F7	-5103
CDK2	-5005

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1B	-18553
TP53	-18115
E2F8	-18090
CCNA1	-15733
ZNF385A	-15144
CCNE1	-14745
CCNA2	-14537
CCNE2	-13663
PCBP4	-13158
CDKN1A	-12698
E2F1	-11507
ARID3A	-10892
E2F7	-5103
CDK2	-5005

---

SUMOylation of immune response proteins

SUMOylation of immune response proteins

	1183
set	SUMOylation of immune response proteins
setSize	10
pANOVA	0.00136
s.dist	-0.585
p.adjustANOVA	0.00451

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TOPORS	-17178
PIAS3	-17089
NFKB2	-16966
NFKBIA	-14792
IKBKE	-14457
PIAS4	-13250
SUMO1	-13076
RELA	-10345
UBE2I	-9524
SUMO3	-4815

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TOPORS	-17178
PIAS3	-17089
NFKB2	-16966
NFKBIA	-14792
IKBKE	-14457
PIAS4	-13250
SUMO1	-13076
RELA	-10345
UBE2I	-9524
SUMO3	-4815

---

Activation of the TFAP2 (AP-2) family of transcription factors

Activation of the TFAP2 (AP-2) family of transcription factors

	54
set	Activation of the TFAP2 (AP-2) family of transcription factors
setSize	11
pANOVA	0.000845
s.dist	-0.581
p.adjustANOVA	0.00293

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TFAP2B	-18471
TFAP2A	-18394
CITED2	-18372
TFAP2D	-18357
TFAP2E	-17907
CITED4	-17421
YEATS4	-14645
TFAP2C	-11452
CREBBP	-7878
EP300	-7133
WWOX	5914

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TFAP2B	-18471
TFAP2A	-18394
CITED2	-18372
TFAP2D	-18357
TFAP2E	-17907
CITED4	-17421
YEATS4	-14645
TFAP2C	-11452
CREBBP	-7878
EP300	-7133
WWOX	5914

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	395
set	Eukaryotic Translation Elongation
setSize	88
pANOVA	4.99e-21
s.dist	-0.579
p.adjustANOVA	2.18e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
RPS21	-17992
EEF1B2	-17849
FAU	-17763
RPL41	-17725
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
RPL13	-17240
RPS10	-17143
EEF1A1	-17137

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
RPS21	-17992.0
EEF1B2	-17849.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
RPS10	-17143.0
EEF1A1	-17137.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
RPL36	-16817.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
EEF1A2	-15575.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
EEF1D	-14805.0
RPL35	-14710.0
RPL18A	-14604.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
RPS15A	-10561.0
RPL8	-10300.0
EEF1G	-10263.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
EEF2	-9928.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
RPS20	-7800.0
RPL3L	-7402.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
RPS6	-4952.0
RPS7	-4816.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
RPS9	0.5
RPS17	0.5

---

Viral mRNA Translation

Viral mRNA Translation

	1478
set	Viral mRNA Translation
setSize	84
pANOVA	8.07e-20
s.dist	-0.574
p.adjustANOVA	3.01e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
RPS21	-17992
FAU	-17763
RPL41	-17725
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
RPL13	-17240
RPS10	-17143
RPL31	-17100
RPS16	-17067

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
RPS21	-17992.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
RPL36	-16817.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
RPL18A	-14604.0
DNAJC3	-14594.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
GRSF1	-13222.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
RPS15A	-10561.0
RPL8	-10300.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
RPS20	-7800.0
RPL3L	-7402.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
RPS6	-4952.0
RPS7	-4816.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
RPS9	0.5
RPS17	0.5

---

Peptide chain elongation

Peptide chain elongation

	896
set	Peptide chain elongation
setSize	84
pANOVA	8.92e-20
s.dist	-0.574
p.adjustANOVA	3.25e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
RPS21	-17992
FAU	-17763
RPL41	-17725
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
RPL13	-17240
RPS10	-17143
EEF1A1	-17137
RPL31	-17100

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
RPS21	-17992.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
RPS10	-17143.0
EEF1A1	-17137.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
RPL36	-16817.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
RPL18A	-14604.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
RPS15A	-10561.0
RPL8	-10300.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
EEF2	-9928.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
RPS20	-7800.0
RPL3L	-7402.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
RPS6	-4952.0
RPS7	-4816.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
RPS9	0.5
RPS17	0.5

---

Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes

	227
set	Condensation of Prometaphase Chromosomes
setSize	11
pANOVA	0.00105
s.dist	-0.57
p.adjustANOVA	0.00358

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSNK2B	-18485
SMC2	-17576
SMC4	-16947
NCAPG	-16323
CDK1	-14000
NCAPH	-13829
CCNB2	-13717
CSNK2A1	-10601
NCAPD2	-8495
CCNB1	-7457
CSNK2A2	-5161

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSNK2B	-18485
SMC2	-17576
SMC4	-16947
NCAPG	-16323
CDK1	-14000
NCAPH	-13829
CCNB2	-13717
CSNK2A1	-10601
NCAPD2	-8495
CCNB1	-7457
CSNK2A2	-5161

---

Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

	1340
set	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
setSize	12
pANOVA	0.000643
s.dist	-0.569
p.adjustANOVA	0.00234

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PAX6	-18577
SPCS1	-18491
ISL1	-18085
SPCS3	-15153
SEC11C	-14981
GATA4	-14248
SEC11A	-14143
PCSK1	-13665
SPCS2	-11202
GIP	-8991
DPP4	-4719
FFAR1	-3049

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PAX6	-18577
SPCS1	-18491
ISL1	-18085
SPCS3	-15153
SEC11C	-14981
GATA4	-14248
SEC11A	-14143
PCSK1	-13665
SPCS2	-11202
GIP	-8991
DPP4	-4719
FFAR1	-3049

---

Beta defensins

Beta defensins

	117
set	Beta defensins
setSize	32
pANOVA	2.54e-08
s.dist	0.569
p.adjustANOVA	2.38e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DEFB132	7424.0
DEFB105A	7375.5
DEFB1	7276.0
DEFB129	7156.0
DEFB116	7034.0
DEFB104A	7008.5
DEFB108B	6902.0
DEFB123	6885.0
DEFB118	6488.0
DEFB106A	6116.5
DEFB113	5988.0
DEFB134	5688.0
CCR6	5518.0
CCR2	5257.0
DEFB135	4930.0
DEFB115	4379.0
TLR1	4344.0
DEFB114	4086.0
DEFB133	1260.0
DEFB127	0.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DEFB132	7424.0
DEFB105A	7375.5
DEFB1	7276.0
DEFB129	7156.0
DEFB116	7034.0
DEFB104A	7008.5
DEFB108B	6902.0
DEFB123	6885.0
DEFB118	6488.0
DEFB106A	6116.5
DEFB113	5988.0
DEFB134	5688.0
CCR6	5518.0
CCR2	5257.0
DEFB135	4930.0
DEFB115	4379.0
TLR1	4344.0
DEFB114	4086.0
DEFB133	1260.0
DEFB127	0.5
DEFB126	0.5
DEFB110	0.5
DEFB107A	0.5
DEFB125	0.5
DEFB103A	0.5
DEFB124	-1931.0
DEFB136	-4205.0
DEFB128	-6913.0
DEFB121	-7537.0
DEFB131	-8708.0
TLR2	-9339.0
DEFB119	-11197.0

---

Constitutive Signaling by Overexpressed ERBB2

Constitutive Signaling by Overexpressed ERBB2

	236
set	Constitutive Signaling by Overexpressed ERBB2
setSize	10
pANOVA	0.00187
s.dist	-0.568
p.adjustANOVA	0.00595

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KRAS	-18405
SHC1	-17113
HSP90AA1	-16118
CDC37	-14502
HRAS	-14339
ERBB2	-13877
GRB2	-13425
PTPN12	-11186
NRAS	-5537
SOS1	-4813

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KRAS	-18405
SHC1	-17113
HSP90AA1	-16118
CDC37	-14502
HRAS	-14339
ERBB2	-13877
GRB2	-13425
PTPN12	-11186
NRAS	-5537
SOS1	-4813

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	1172
set	SRP-dependent cotranslational protein targeting to membrane
setSize	105
pANOVA	1.7e-23
s.dist	-0.563
p.adjustANOVA	1e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SPCS1	-18491
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
SRP72	-18067
RPL18	-18029
RPS21	-17992
FAU	-17763
RPL41	-17725
SRP14	-17717
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
SRP54	-17345
RPS13	-17324

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SPCS1	-18491.0
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
SRP72	-18067.0
RPL18	-18029.0
RPS21	-17992.0
FAU	-17763.0
RPL41	-17725.0
SRP14	-17717.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
SRP54	-17345.0
RPS13	-17324.0
RPL13	-17240.0
SEC61G	-17182.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
RPL36	-16817.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
SRP9	-15608.0
RPL37A	-15505.0
RPL7	-15268.0
SPCS3	-15153.0
RPL17	-15007.0
SEC11C	-14981.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
SEC61A1	-14695.0
RPL18A	-14604.0
RPN2	-14488.0
SSR3	-14297.0
RPL32	-14215.0
SEC11A	-14143.0
SRP19	-14064.0
RPL35A	-13949.0
RPL22L1	-13936.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPN1	-12715.0
RPL37	-12236.0
RPL19	-12092.0
SEC61B	-12083.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
SPCS2	-11202.0
RPS15A	-10561.0
RPL8	-10300.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
RPL36AL	-9579.0
RPS12	-9472.0
DDOST	-9175.0
RPL34	-8988.0
RPS19	-8827.0
SRPRB	-8239.0
RPS20	-7800.0
TRAM1	-7796.0
RPL3L	-7402.0
SEC61A2	-7246.0
SSR2	-6671.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
RPS6	-4952.0
RPS7	-4816.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
SRP68	-2412.0
SSR1	-1169.0
RPS9	0.5
RPS17	0.5

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	397
set	Eukaryotic Translation Termination
setSize	87
pANOVA	1.24e-19
s.dist	-0.562
p.adjustANOVA	4.41e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRMT112	-18345
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
RPS21	-17992
FAU	-17763
RPL41	-17725
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
RPL13	-17240
RPS10	-17143
RPL31	-17100

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRMT112	-18345.0
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
RPS21	-17992.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
RPL36	-16817.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
RPL18A	-14604.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
RPS15A	-10561.0
RPL8	-10300.0
GSPT1	-10150.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
APEH	-9854.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
RPS20	-7800.0
RPL3L	-7402.0
N6AMT1	-7188.0
ETF1	-6614.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
RPS6	-4952.0
RPS7	-4816.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
RPS9	0.5
RPS17	0.5

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	449
set	Formation of a pool of free 40S subunits
setSize	95
pANOVA	2.4e-20
s.dist	-0.548
p.adjustANOVA	9.39e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
EIF3I	-18000
RPS21	-17992
EIF3J	-17815
FAU	-17763
RPL41	-17725
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
RPL13	-17240
RPS10	-17143

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
EIF3I	-18000.0
RPS21	-17992.0
EIF3J	-17815.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
RPL36	-16817.0
EIF3K	-16720.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
EIF3M	-14684.0
RPL18A	-14604.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
EIF3L	-13293.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
EIF3F	-12161.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
EIF3B	-11318.0
RPLP1	-11260.0
RPS8	-11243.0
RPS15A	-10561.0
RPL8	-10300.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
EIF3G	-8766.0
EIF3E	-8286.0
RPS20	-7800.0
RPL3L	-7402.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
EIF3A	-5427.0
EIF3C	-5008.0
RPS6	-4952.0
RPS7	-4816.0
EIF3D	-4766.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
EIF3H	-1517.0
RPS9	0.5
RPS17	0.5

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

	1135
set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	95
pANOVA	2.89e-20
s.dist	-0.547
p.adjustANOVA	1.11e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
RPS21	-17992
FAU	-17763
RPL41	-17725
ATF4	-17689
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
CEBPG	-17253
RPL13	-17240
RPS10	-17143

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
RPS21	-17992.0
FAU	-17763.0
RPL41	-17725.0
ATF4	-17689.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
CEBPG	-17253.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
EIF2S2	-16852.0
RPL36	-16817.0
RPS18	-16566.0
DDIT3	-16564.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
CEBPB	-15905.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
RPL18A	-14604.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
ASNS	-11238.0
ATF2	-11009.0
EIF2S1	-10838.0
RPS15A	-10561.0
RPL8	-10300.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
ATF3	-8602.0
RPS20	-7800.0
RPL3L	-7402.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
EIF2AK4	-5744.0
RPS6	-4952.0
RPS7	-4816.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
TRIB3	-3275.0
RPL10L	-3163.0
RPS24	-2438.0
IMPACT	-2347.0
RPS9	0.5
RPS17	0.5
GCN1	1034.0

---

Defensins

Defensins

	299
set	Defensins
setSize	40
pANOVA	2.56e-09
s.dist	0.544
p.adjustANOVA	3.11e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DEFB132	7424.0
DEFB105A	7375.5
DEFB1	7276.0
DEFB129	7156.0
DEFB116	7034.0
DEFB104A	7008.5
DEFB108B	6902.0
DEFB123	6885.0
DEFB118	6488.0
DEFB106A	6116.5
DEFB113	5988.0
DEFB134	5688.0
CCR6	5518.0
CCR2	5257.0
DEFA1	5106.5
DEFA6	4989.0
DEFB135	4930.0
DEFB115	4379.0
TLR1	4344.0
DEFA3	4163.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DEFB132	7424.0
DEFB105A	7375.5
DEFB1	7276.0
DEFB129	7156.0
DEFB116	7034.0
DEFB104A	7008.5
DEFB108B	6902.0
DEFB123	6885.0
DEFB118	6488.0
DEFB106A	6116.5
DEFB113	5988.0
DEFB134	5688.0
CCR6	5518.0
CCR2	5257.0
DEFA1	5106.5
DEFA6	4989.0
DEFB135	4930.0
DEFB115	4379.0
TLR1	4344.0
DEFA3	4163.0
DEFB114	4086.0
DEFA5	3341.0
DEFB133	1260.0
DEFB127	0.5
DEFB126	0.5
DEFB110	0.5
DEFB107A	0.5
DEFB125	0.5
DEFB103A	0.5
DEFB124	-1931.0
PRSS3	-2216.0
DEFA4	-3477.0
CD4	-4053.0
DEFB136	-4205.0
ART1	-5480.0
DEFB128	-6913.0
DEFB121	-7537.0
DEFB131	-8708.0
TLR2	-9339.0
DEFB119	-11197.0

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	493
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	105
pANOVA	7.61e-22
s.dist	-0.542
p.adjustANOVA	3.63e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
EIF3I	-18000
RPS21	-17992
EIF3J	-17815
FAU	-17763
RPL41	-17725
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
RPL13	-17240
RPS10	-17143

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
EIF3I	-18000.0
RPS21	-17992.0
EIF3J	-17815.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
EIF2S2	-16852.0
RPL36	-16817.0
EIF3K	-16720.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
EIF5B	-16282.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
EIF4H	-15938.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
EIF5	-15532.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
EIF3M	-14684.0
RPL18A	-14604.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
EIF4A2	-13846.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
EIF3L	-13293.0
EIF4B	-13109.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
EIF3F	-12161.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
EIF3B	-11318.0
RPLP1	-11260.0
RPS8	-11243.0
EIF2S1	-10838.0
RPS15A	-10561.0
RPL8	-10300.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
EIF4A1	-9770.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
EIF3G	-8766.0
EIF3E	-8286.0
RPS20	-7800.0
RPL3L	-7402.0
EIF4E	-6926.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
EIF3A	-5427.0
EIF3C	-5008.0
RPS6	-4952.0
RPS7	-4816.0
EIF3D	-4766.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
EIF3H	-1517.0
RPS9	0.5
RPS17	0.5
EIF4G1	1462.0

---

ERKs are inactivated

ERKs are inactivated

	375
set	ERKs are inactivated
setSize	13
pANOVA	0.000736
s.dist	-0.541
p.adjustANOVA	0.00263

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DUSP6	-18550
MAPK7	-17794
PPP2R5D	-17678
DUSP7	-17591
PPP2CA	-17436
PPP2R1A	-17243
DUSP4	-16615
VRK3	-14146
MAPK3	-13940
DUSP3	-12648
PPP2R1B	-4016
MAPK1	1912
PPP2CB	2294

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DUSP6	-18550
MAPK7	-17794
PPP2R5D	-17678
DUSP7	-17591
PPP2CA	-17436
PPP2R1A	-17243
DUSP4	-16615
VRK3	-14146
MAPK3	-13940
DUSP3	-12648
PPP2R1B	-4016
MAPK1	1912
PPP2CB	2294

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

	165
set	Cap-dependent Translation Initiation
setSize	112
pANOVA	1.14e-22
s.dist	-0.535
p.adjustANOVA	6.03e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
EIF3I	-18000
RPS21	-17992
EIF3J	-17815
FAU	-17763
RPL41	-17725
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
RPL13	-17240
RPS10	-17143

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
EIF3I	-18000.0
RPS21	-17992.0
EIF3J	-17815.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
EIF2S2	-16852.0
RPL36	-16817.0
EIF2B4	-16802.0
EIF3K	-16720.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
EIF5B	-16282.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
EIF4H	-15938.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
EIF2B2	-15615.0
EIF5	-15532.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
EIF3M	-14684.0
RPL18A	-14604.0
RPL32	-14215.0
EIF2B1	-14114.0
RPL35A	-13949.0
RPL22L1	-13936.0
EIF4A2	-13846.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
EIF3L	-13293.0
EIF4B	-13109.0
EIF4EBP1	-13068.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
EIF2B5	-12663.0
RPL37	-12236.0
EIF3F	-12161.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
EIF3B	-11318.0
RPLP1	-11260.0
RPS8	-11243.0
EIF2S1	-10838.0
RPS15A	-10561.0
RPL8	-10300.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
EIF4A1	-9770.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
EIF3G	-8766.0
PABPC1	-8458.0
EIF3E	-8286.0
RPS20	-7800.0
RPL3L	-7402.0
EIF4E	-6926.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
EIF3A	-5427.0
EIF3C	-5008.0
RPS6	-4952.0
RPS7	-4816.0
EIF3D	-4766.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
EIF3H	-1517.0
RPS9	0.5
RPS17	0.5
EIF4G1	1462.0
EIF2B3	2605.0

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

	396
set	Eukaryotic Translation Initiation
setSize	112
pANOVA	1.14e-22
s.dist	-0.535
p.adjustANOVA	6.03e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
EIF3I	-18000
RPS21	-17992
EIF3J	-17815
FAU	-17763
RPL41	-17725
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
RPL13	-17240
RPS10	-17143

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
EIF3I	-18000.0
RPS21	-17992.0
EIF3J	-17815.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
EIF2S2	-16852.0
RPL36	-16817.0
EIF2B4	-16802.0
EIF3K	-16720.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
EIF5B	-16282.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
EIF4H	-15938.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
EIF2B2	-15615.0
EIF5	-15532.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
EIF3M	-14684.0
RPL18A	-14604.0
RPL32	-14215.0
EIF2B1	-14114.0
RPL35A	-13949.0
RPL22L1	-13936.0
EIF4A2	-13846.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
EIF3L	-13293.0
EIF4B	-13109.0
EIF4EBP1	-13068.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
EIF2B5	-12663.0
RPL37	-12236.0
EIF3F	-12161.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
EIF3B	-11318.0
RPLP1	-11260.0
RPS8	-11243.0
EIF2S1	-10838.0
RPS15A	-10561.0
RPL8	-10300.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
EIF4A1	-9770.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
EIF3G	-8766.0
PABPC1	-8458.0
EIF3E	-8286.0
RPS20	-7800.0
RPL3L	-7402.0
EIF4E	-6926.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
EIF3A	-5427.0
EIF3C	-5008.0
RPS6	-4952.0
RPS7	-4816.0
EIF3D	-4766.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
EIF3H	-1517.0
RPS9	0.5
RPS17	0.5
EIF4G1	1462.0
EIF2B3	2605.0

---

Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors

	399
set	Expression and translocation of olfactory receptors
setSize	365
pANOVA	1.75e-69
s.dist	0.535
p.adjustANOVA	2.68e-66

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR2L8	7406
OR52E8	7401
RTP1	7385
OR1D2	7370
OR8B8	7362
OR2AG2	7350
OR5V1	7344
OR1N1	7334
OR1J4	7289
OR9A2	7275
OR2A5	7267
OR6A2	7262
OR13C8	7221
OR13A1	7215
OR11G2	7201
OR8U8	7158
OR11H4	7128
OR5M8	7095
OR7C1	7090
OR2B2	7086

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR2L8	7406.0
OR52E8	7401.0
RTP1	7385.0
OR1D2	7370.0
OR8B8	7362.0
OR2AG2	7350.0
OR5V1	7344.0
OR1N1	7334.0
OR1J4	7289.0
OR9A2	7275.0
OR2A5	7267.0
OR6A2	7262.0
OR13C8	7221.0
OR13A1	7215.0
OR11G2	7201.0
OR8U8	7158.0
OR11H4	7128.0
OR5M8	7095.0
OR7C1	7090.0
OR2B2	7086.0
OR8D1	7040.0
OR51F2	7039.0
OR10G8	7012.0
OR5B21	6956.0
OR2T8	6917.0
OR6C1	6911.0
OR2H1	6903.0
OR5AS1	6890.0
OR51E2	6862.0
OR8H3	6842.0
OR52I2	6818.0
OR51A7	6788.0
OR2A2	6743.0
OR8A1	6742.0
OR8K3	6715.0
OR5M9	6696.0
OR10G7	6648.0
OR1J2	6619.0
OR56A4	6607.0
OR6B1	6564.0
OR5T2	6489.0
OR9Q1	6487.0
OR10H4	6467.0
OR2D2	6420.0
OR6K6	6417.0
OR9A4	6414.0
OR13G1	6396.0
OR8H2	6349.0
OR10G9	6310.0
OR7C2	6295.0
OR6X1	6289.0
OR2F1	6286.0
OR2AE1	6274.0
OR52J3	6226.0
OR13C3	6218.0
OR8K1	6216.0
OR52N1	6199.0
OR52D1	6168.0
OR7E24	6146.0
OR1N2	6139.0
OR10H3	6078.0
OR4N5	6069.0
OR2W1	6021.0
OR7A10	5996.0
OR5P2	5984.0
OR10Q1	5970.0
OR5H2	5966.0
OR6K2	5965.0
OR5L1	5921.0
OR52A1	5920.0
OR9I1	5900.0
OR10X1	5865.0
OR5AP2	5859.0
OR2AK2	5793.0
OR2L3	5789.0
OR6C65	5774.0
OR1S2	5716.0
OR4K13	5701.0
OR1J1	5641.0
OR2B3	5636.0
OR11A1	5583.0
OR10G3	5578.0
OR2J3	5529.0
OR2G2	5515.0
OR6C75	5511.0
OR2V2	5503.0
OR6M1	5465.0
OR6C76	5455.0
OR4K1	5453.0
OR4E2	5435.0
OR7G1	5432.0
OR5A1	5427.0
OR2B6	5424.0
OR10J1	5411.0
OR56A3	5375.0
OR2M5	5359.0
OR2M7	5331.0
OR5A2	5315.0
OR12D2	5275.0
OR56B1	5255.0
OR10A6	5191.0
OR6T1	5188.0
OR5C1	5187.0
OR2T33	5174.0
OR5T3	5154.0
OR2A14	5152.0
OR51G1	5149.0
OR13C9	5102.0
OR52K1	5025.0
OR6C2	4994.0
OR7D2	4984.0
OR5I1	4982.0
OR4K5	4976.0
OR10AG1	4924.0
OR8G2	4920.0
OR2L2	4826.0
OR8B2	4816.0
OR4N2	4811.0
OR2AG1	4788.0
OR6C68	4687.0
OR5M3	4680.0
OR5R1	4642.0
OR6B2	4551.0
OR7A17	4525.0
OR9G4	4519.0
OR10H5	4482.0
OR2M3	4431.0
OR9Q2	4425.0
OR5M11	4424.0
OR52E6	4377.0
OR10G4	4361.0
OR12D3	4358.0
OR51B5	4349.0
OR1Q1	4300.0
OR2M2	4299.0
OR2D3	4289.0
OR2J2	4275.0
OR4D2	4135.0
OR2L13	4116.0
OR4A15	4064.0
OR6K3	3996.0
OR8J3	3984.0
OR10G2	3983.0
OR10K2	3980.0
OR10K1	3965.0
OR2C3	3949.0
OR2W5	3879.0
OR5K4	3799.0
OR51Q1	3738.0
OR7A5	3731.0
OR8G1	3672.0
OR2G3	3650.0
OR2T11	3639.0
OR6C70	3615.0
OR10S1	3567.0
OR8B4	3499.0
OR8D2	3397.0
OR13F1	3378.0
OR51T1	3377.0
OR6Y1	3276.0
OR52L1	3273.0
OR2H2	3180.0
OR5F1	3174.0
OR5B3	3158.0
OR52K2	3145.0
OR6C4	3139.0
OR2T6	3120.0
OR1K1	3069.0
OR9K2	3057.0
OR51B2	2998.0
OR2T1	2969.0
OR8K5	2785.0
OR3A2	2682.0
OR51A2	2577.0
OR4F15	2543.0
OR51E1	2501.0
OR6V1	2490.0
OR51I1	2415.0
OR51S1	2297.0
OR10H1	2282.0
EBF1	2152.0
OR4A47	2028.0
OR51L1	2003.0
OR4D10	1960.0
OR10A3	1850.0
OR5W2	1353.0
OR1B1	1352.0
OR4K17	1270.0
OR5B12	1094.0
OR5T1	0.5
OR10Z1	0.5
OR52A5	0.5
OR5K2	0.5
OR4A5	0.5
OR51D1	0.5
OR10W1	0.5
OR2A12	0.5
OR1I1	0.5
OR52H1	0.5
OR52E2	0.5
OR5D16	0.5
OR52B2	0.5
OR6B3	0.5
OR4C46	0.5
OR2S2	0.5
OR56A1	0.5
OR1S1	0.5
OR6N1	0.5
OR6F1	0.5
OR2A25	0.5
OR8I2	0.5
OR51V1	0.5
OR14J1	0.5
OR5H1	0.5
OR2T2	0.5
OR4F4	0.5
OR10J5	0.5
OR5D13	0.5
OR5D14	0.5
OR2T12	0.5
OR51B4	0.5
OR52E4	0.5
OR52N2	0.5
OR52N5	0.5
OR2A1	0.5
OR5K3	0.5
OR4K15	0.5
OR4C6	0.5
OR4B1	0.5
OR2K2	0.5
OR8D4	0.5
OR6S1	0.5
OR52M1	0.5
OR2T35	0.5
OR5J2	0.5
OR51G2	0.5
OR1D5	0.5
OR1D4	0.5
OR5M1	0.5
OR4D6	0.5
OR56A5	0.5
OR6C3	0.5
OR5K1	0.5
OR56B4	0.5
OR8B3	0.5
OR4C16	0.5
OR8U1	0.5
OR5AN1	0.5
OR13C4	0.5
OR4X2	0.5
OR13C2	0.5
OR8J1	0.5
OR4S1	0.5
OR4C13	0.5
OR2Y1	0.5
OR6Q1	0.5
OR4N4	0.5
OR4D9	0.5
OR5AR1	0.5
OR51F1	0.5
OR5B2	0.5
OR2W3	0.5
OR5H14	0.5
OR2F2	0.5
OR8H1	0.5
OR8G5	0.5
OR6C6	0.5
OR5AK2	0.5
OR5L2	0.5
OR10R2	0.5
OR2A4	0.5
OR52N4	0.5
OR4D5	0.5
OR2L5	0.5
OR1L4	0.5
OR1L6	0.5
OR13D1	0.5
OR2AP1	0.5
OR4K14	0.5
OR2C1	-1077.0
OR4D1	-1099.0
OR6N2	-1372.0
OR4D11	-1532.0
OR8B12	-1579.0
OR1L3	-1602.0
OR1A1	-1627.0
OR4M2	-1873.0
OR2V1	-1878.0
OR1L1	-2056.0
OR52B6	-2059.0
OR5D18	-2122.0
OR4K2	-2123.0
OR5AU1	-2183.0
RTP2	-2236.0
OR10A4	-2270.0
OR2G6	-2271.0
OR10J3	-2328.0
OR10AD1	-2475.0
OR2T29	-2511.0
OR10H2	-2558.0
OR4F6	-2770.0
OR4A16	-2829.0
OR13J1	-2999.0
OR5AC2	-3060.0
OR11L1	-3235.0
OR2T5	-3245.0
OR51M1	-3456.0
OR4M1	-3467.0
OR1E1	-3549.0
OR4X1	-3668.0
OR9G1	-3822.5
OR9G9	-3822.5
OR52I1	-3828.0
OR7G3	-4117.0
OR10V1	-4155.0
OR1A2	-4173.0
OR14A16	-4241.0
OR52R1	-4246.0
OR10A5	-4400.0
OR2Z1	-4600.0
OR2M4	-4666.0
OR14C36	-4769.0
OR51B6	-4881.0
OR10T2	-5043.0
OR10P1	-5110.0
OR1L8	-5279.0
OR7G2	-5335.0
OR1C1	-5538.0
OR8S1	-5621.0
OR5H6	-5700.0
OR51I2	-5714.0
OR3A1	-5799.0
OR6C74	-5941.0
OR4C12	-5950.0
OR5B17	-6005.0
OR7D4	-6047.0
OR10A7	-6305.0
OR1E2	-6338.0
OR4C15	-6367.0
OR11H6	-6375.0
OR5M10	-6556.0
OR2T4	-6581.0
OR4L1	-6679.0
OR2T3	-7086.0
OR4C45	-7637.0
OR10A2	-7807.0
OR4Q3	-7837.0
OR1F1	-8004.0
OR2T34	-8011.0
OR5P3	-8036.0
OR6P1	-8163.0
OR2B11	-8173.0
OR2T27	-8370.0
OR52W1	-8489.0
OR2AT4	-8983.0
OR3A3	-9302.0
OR1M1	-9387.0
OR4F5	-9440.0
OR14I1	-10018.0
OR10C1	-10068.0
REEP1	-11079.0
OR1G1	-12224.0
OR4C3	-13127.0
LHX2	-17131.0
LDB1	-17974.0

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	660
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	104
pANOVA	4.59e-21
s.dist	-0.534
p.adjustANOVA	2.06e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
EIF3I	-18000
RPS21	-17992
EIF3J	-17815
FAU	-17763
RPL41	-17725
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
RPL13	-17240
RPS10	-17143

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
EIF3I	-18000.0
RPS21	-17992.0
EIF3J	-17815.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
EIF2S2	-16852.0
RPL36	-16817.0
EIF3K	-16720.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
EIF4H	-15938.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
EIF3M	-14684.0
RPL18A	-14604.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
EIF4A2	-13846.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
EIF3L	-13293.0
EIF4B	-13109.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
EIF3F	-12161.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
EIF3B	-11318.0
RPLP1	-11260.0
RPS8	-11243.0
EIF2S1	-10838.0
RPS15A	-10561.0
RPL8	-10300.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
EIF4A1	-9770.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
EIF3G	-8766.0
PABPC1	-8458.0
EIF3E	-8286.0
RPS20	-7800.0
RPL3L	-7402.0
EIF4E	-6926.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
EIF3A	-5427.0
EIF3C	-5008.0
RPS6	-4952.0
RPS7	-4816.0
EIF3D	-4766.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
EIF3H	-1517.0
RPS9	0.5
RPS17	0.5
EIF4G1	1462.0

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	822
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	89
pANOVA	3.01e-18
s.dist	-0.534
p.adjustANOVA	9.03e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
RPS21	-17992
FAU	-17763
RPL41	-17725
RPS25	-17651
NCBP1	-17533
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
RPL13	-17240
RPS10	-17143
RPL31	-17100

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
RPS21	-17992.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
NCBP1	-17533.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
RPL36	-16817.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
RPL18A	-14604.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
RPS15A	-10561.0
RPL8	-10300.0
GSPT1	-10150.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
PABPC1	-8458.0
RPS20	-7800.0
RPL3L	-7402.0
ETF1	-6614.0
RPL3	-6287.0
RPL38	-6212.0
NCBP2	-5801.0
RPL7A	-5788.0
RPS6	-4952.0
RPS7	-4816.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
RPS9	0.5
RPS17	0.5
EIF4G1	1462.0
UPF1	1808.0

---

Mitochondrial translation termination

Mitochondrial translation termination

	746
set	Mitochondrial translation termination
setSize	87
pANOVA	7.37e-18
s.dist	-0.533
p.adjustANOVA	2.11e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS18B	-18393
MRPL41	-18391
GFM2	-18256
MRPS11	-18028
MRPL51	-17993
MRPL46	-17951
MTRF1L	-17812
MRPS26	-17629
MRPL17	-17331
AURKAIP1	-17254
MRPS2	-17122
MRPS7	-17059
MRPL38	-16998
MRPS16	-16944
MRPL49	-16785
MRPS12	-16777
OXA1L	-16745
MRPS30	-16660
MRPL32	-16598
MRPL40	-16572

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS18B	-18393
MRPL41	-18391
GFM2	-18256
MRPS11	-18028
MRPL51	-17993
MRPL46	-17951
MTRF1L	-17812
MRPS26	-17629
MRPL17	-17331
AURKAIP1	-17254
MRPS2	-17122
MRPS7	-17059
MRPL38	-16998
MRPS16	-16944
MRPL49	-16785
MRPS12	-16777
OXA1L	-16745
MRPS30	-16660
MRPL32	-16598
MRPL40	-16572
MRPL53	-16537
MRPL30	-16488
MRPL55	-16411
MRPL36	-16381
MRPS5	-16088
MRPL54	-16000
MRPS34	-15882
CHCHD1	-15791
MRPS15	-15740
MRPL57	-15726
MRPL37	-15540
MRPL47	-15298
MRPS31	-15145
MRPL43	-14902
MRPL10	-14826
MRPS18C	-14513
MRPS23	-14458
MRPL50	-13972
PTCD3	-13932
MRPS24	-13585
MRPL11	-13539
ERAL1	-13515
MRPS33	-13337
MRPS18A	-13331
MRPL12	-13230
MRPS10	-13036
MRPL44	-12940
MRPL4	-12597
MRPS9	-12505
MRPL3	-12280
MRPL14	-12121
MRPL13	-11757
MRPL15	-11680
MRPL24	-11369
MRPL2	-11290
MRPS17	-11108
MRPL39	-11066
MRPS25	-10790
MRPL42	-10577
MRPL27	-10322
MRPL21	-10164
MRPL9	-10027
MRPL1	-9933
MRPL18	-9780
MRPL33	-9729
MRPL52	-9393
MRPL23	-9350
DAP3	-9134
MRRF	-9114
MRPS35	-8363
MRPS22	-8186
MRPL28	-8155
MRPL19	-8042
GADD45GIP1	-7961
MRPS6	-7875
MRPL34	-7707
MRPS36	-7680
MRPL35	-7174
MRPS27	-7135
MRPL20	-6324
MRPL16	-5712
MRPS28	-5568
MRPS21	-4530
MRPS14	-4094
MRPL22	-2713
MRPL48	1052
MRPL45	5801

---

Selenocysteine synthesis

Selenocysteine synthesis

	1193
set	Selenocysteine synthesis
setSize	87
pANOVA	7.47e-18
s.dist	-0.533
p.adjustANOVA	2.11e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
RPS21	-17992
FAU	-17763
RPL41	-17725
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
RPL13	-17240
RPS10	-17143
RPL31	-17100
RPS16	-17067

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
RPS21	-17992.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
RPL36	-16817.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
RPL18A	-14604.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
RPS15A	-10561.0
RPL8	-10300.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
SEPHS2	-9892.0
RPL36AL	-9579.0
RPS12	-9472.0
RPL34	-8988.0
RPS19	-8827.0
RPS20	-7800.0
RPL3L	-7402.0
RPL3	-6287.0
SEPSECS	-6223.0
RPL38	-6212.0
RPL7A	-5788.0
EEFSEC	-5223.0
RPS6	-4952.0
RPS7	-4816.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
SECISBP2	-1193.0
RPS9	0.5
RPS17	0.5
PSTK	2488.0

---

Mitochondrial translation

Mitochondrial translation

	743
set	Mitochondrial translation
setSize	93
pANOVA	1.12e-18
s.dist	-0.529
p.adjustANOVA	3.57e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS18B	-18393
MRPL41	-18391
GFM2	-18256
MRPS11	-18028
MRPL51	-17993
MRPL46	-17951
MTRF1L	-17812
MRPS26	-17629
MTIF3	-17382
MRPL17	-17331
AURKAIP1	-17254
MRPS2	-17122
MRPS7	-17059
MRPL38	-16998
MRPS16	-16944
MRPL49	-16785
MRPS12	-16777
OXA1L	-16745
MRPS30	-16660
MRPL32	-16598

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS18B	-18393
MRPL41	-18391
GFM2	-18256
MRPS11	-18028
MRPL51	-17993
MRPL46	-17951
MTRF1L	-17812
MRPS26	-17629
MTIF3	-17382
MRPL17	-17331
AURKAIP1	-17254
MRPS2	-17122
MRPS7	-17059
MRPL38	-16998
MRPS16	-16944
MRPL49	-16785
MRPS12	-16777
OXA1L	-16745
MRPS30	-16660
MRPL32	-16598
MRPL40	-16572
MRPL53	-16537
MRPL30	-16488
MRPL55	-16411
MRPL36	-16381
MRPS5	-16088
MRPL54	-16000
MRPS34	-15882
CHCHD1	-15791
MRPS15	-15740
MRPL57	-15726
MRPL37	-15540
MRPL47	-15298
MRPS31	-15145
MRPL43	-14902
MRPL10	-14826
TUFM	-14732
MRPS18C	-14513
MRPS23	-14458
MTFMT	-14120
MRPL50	-13972
PTCD3	-13932
MRPS24	-13585
MRPL11	-13539
ERAL1	-13515
MRPS33	-13337
MRPS18A	-13331
MRPL12	-13230
MRPS10	-13036
GFM1	-12958
MRPL44	-12940
MRPL4	-12597
MRPS9	-12505
MRPL3	-12280
MRPL14	-12121
MRPL13	-11757
MRPL15	-11680
MRPL24	-11369
MRPL2	-11290
MRPS17	-11108
MRPL39	-11066
MRPS25	-10790
MRPL42	-10577
MRPL27	-10322
MRPL21	-10164
MRPL9	-10027
MRPL1	-9933
MRPL18	-9780
MRPL33	-9729
MRPL52	-9393
MRPL23	-9350
DAP3	-9134
MRRF	-9114
MRPS35	-8363
MRPS22	-8186
MRPL28	-8155
MRPL19	-8042
GADD45GIP1	-7961
MRPS6	-7875
MRPL34	-7707
MRPS36	-7680
TSFM	-7299
MRPL35	-7174
MRPS27	-7135
MRPL20	-6324
MRPL16	-5712
MRPS28	-5568
MRPS21	-4530
MRPS14	-4094
MRPL22	-2713
MTIF2	-2456
MRPL48	1052
MRPL45	5801

---

Mitochondrial translation elongation

Mitochondrial translation elongation

	744
set	Mitochondrial translation elongation
setSize	87
pANOVA	2.59e-17
s.dist	-0.524
p.adjustANOVA	7.2e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS18B	-18393
MRPL41	-18391
MRPS11	-18028
MRPL51	-17993
MRPL46	-17951
MRPS26	-17629
MRPL17	-17331
AURKAIP1	-17254
MRPS2	-17122
MRPS7	-17059
MRPL38	-16998
MRPS16	-16944
MRPL49	-16785
MRPS12	-16777
OXA1L	-16745
MRPS30	-16660
MRPL32	-16598
MRPL40	-16572
MRPL53	-16537
MRPL30	-16488

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS18B	-18393
MRPL41	-18391
MRPS11	-18028
MRPL51	-17993
MRPL46	-17951
MRPS26	-17629
MRPL17	-17331
AURKAIP1	-17254
MRPS2	-17122
MRPS7	-17059
MRPL38	-16998
MRPS16	-16944
MRPL49	-16785
MRPS12	-16777
OXA1L	-16745
MRPS30	-16660
MRPL32	-16598
MRPL40	-16572
MRPL53	-16537
MRPL30	-16488
MRPL55	-16411
MRPL36	-16381
MRPS5	-16088
MRPL54	-16000
MRPS34	-15882
CHCHD1	-15791
MRPS15	-15740
MRPL57	-15726
MRPL37	-15540
MRPL47	-15298
MRPS31	-15145
MRPL43	-14902
MRPL10	-14826
TUFM	-14732
MRPS18C	-14513
MRPS23	-14458
MRPL50	-13972
PTCD3	-13932
MRPS24	-13585
MRPL11	-13539
ERAL1	-13515
MRPS33	-13337
MRPS18A	-13331
MRPL12	-13230
MRPS10	-13036
GFM1	-12958
MRPL44	-12940
MRPL4	-12597
MRPS9	-12505
MRPL3	-12280
MRPL14	-12121
MRPL13	-11757
MRPL15	-11680
MRPL24	-11369
MRPL2	-11290
MRPS17	-11108
MRPL39	-11066
MRPS25	-10790
MRPL42	-10577
MRPL27	-10322
MRPL21	-10164
MRPL9	-10027
MRPL1	-9933
MRPL18	-9780
MRPL33	-9729
MRPL52	-9393
MRPL23	-9350
DAP3	-9134
MRPS35	-8363
MRPS22	-8186
MRPL28	-8155
MRPL19	-8042
GADD45GIP1	-7961
MRPS6	-7875
MRPL34	-7707
MRPS36	-7680
TSFM	-7299
MRPL35	-7174
MRPS27	-7135
MRPL20	-6324
MRPL16	-5712
MRPS28	-5568
MRPS21	-4530
MRPS14	-4094
MRPL22	-2713
MRPL48	1052
MRPL45	5801

---

Mitochondrial translation initiation

Mitochondrial translation initiation

	745
set	Mitochondrial translation initiation
setSize	87
pANOVA	2.94e-17
s.dist	-0.523
p.adjustANOVA	8.02e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPS18B	-18393
MRPL41	-18391
MRPS11	-18028
MRPL51	-17993
MRPL46	-17951
MRPS26	-17629
MTIF3	-17382
MRPL17	-17331
AURKAIP1	-17254
MRPS2	-17122
MRPS7	-17059
MRPL38	-16998
MRPS16	-16944
MRPL49	-16785
MRPS12	-16777
OXA1L	-16745
MRPS30	-16660
MRPL32	-16598
MRPL40	-16572
MRPL53	-16537

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPS18B	-18393
MRPL41	-18391
MRPS11	-18028
MRPL51	-17993
MRPL46	-17951
MRPS26	-17629
MTIF3	-17382
MRPL17	-17331
AURKAIP1	-17254
MRPS2	-17122
MRPS7	-17059
MRPL38	-16998
MRPS16	-16944
MRPL49	-16785
MRPS12	-16777
OXA1L	-16745
MRPS30	-16660
MRPL32	-16598
MRPL40	-16572
MRPL53	-16537
MRPL30	-16488
MRPL55	-16411
MRPL36	-16381
MRPS5	-16088
MRPL54	-16000
MRPS34	-15882
CHCHD1	-15791
MRPS15	-15740
MRPL57	-15726
MRPL37	-15540
MRPL47	-15298
MRPS31	-15145
MRPL43	-14902
MRPL10	-14826
MRPS18C	-14513
MRPS23	-14458
MTFMT	-14120
MRPL50	-13972
PTCD3	-13932
MRPS24	-13585
MRPL11	-13539
ERAL1	-13515
MRPS33	-13337
MRPS18A	-13331
MRPL12	-13230
MRPS10	-13036
MRPL44	-12940
MRPL4	-12597
MRPS9	-12505
MRPL3	-12280
MRPL14	-12121
MRPL13	-11757
MRPL15	-11680
MRPL24	-11369
MRPL2	-11290
MRPS17	-11108
MRPL39	-11066
MRPS25	-10790
MRPL42	-10577
MRPL27	-10322
MRPL21	-10164
MRPL9	-10027
MRPL1	-9933
MRPL18	-9780
MRPL33	-9729
MRPL52	-9393
MRPL23	-9350
DAP3	-9134
MRPS35	-8363
MRPS22	-8186
MRPL28	-8155
MRPL19	-8042
GADD45GIP1	-7961
MRPS6	-7875
MRPL34	-7707
MRPS36	-7680
MRPL35	-7174
MRPS27	-7135
MRPL20	-6324
MRPL16	-5712
MRPS28	-5568
MRPS21	-4530
MRPS14	-4094
MRPL22	-2713
MTIF2	-2456
MRPL48	1052
MRPL45	5801

---

Olfactory Signaling Pathway

Olfactory Signaling Pathway

	846
set	Olfactory Signaling Pathway
setSize	372
pANOVA	3.1e-67
s.dist	0.521
p.adjustANOVA	1.58e-64

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR2L8	7406
OR52E8	7401
RTP1	7385
OR1D2	7370
OR8B8	7362
OR2AG2	7350
OR5V1	7344
OR1N1	7334
OR1J4	7289
OR9A2	7275
OR2A5	7267
OR6A2	7262
OR13C8	7221
OR13A1	7215
OR11G2	7201
OR8U8	7158
OR11H4	7128
OR5M8	7095
OR7C1	7090
OR2B2	7086

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR2L8	7406.0
OR52E8	7401.0
RTP1	7385.0
OR1D2	7370.0
OR8B8	7362.0
OR2AG2	7350.0
OR5V1	7344.0
OR1N1	7334.0
OR1J4	7289.0
OR9A2	7275.0
OR2A5	7267.0
OR6A2	7262.0
OR13C8	7221.0
OR13A1	7215.0
OR11G2	7201.0
OR8U8	7158.0
OR11H4	7128.0
OR5M8	7095.0
OR7C1	7090.0
OR2B2	7086.0
OR8D1	7040.0
OR51F2	7039.0
OR10G8	7012.0
OR5B21	6956.0
OR2T8	6917.0
OR6C1	6911.0
OR2H1	6903.0
OR5AS1	6890.0
OR51E2	6862.0
OR8H3	6842.0
OR52I2	6818.0
OR51A7	6788.0
OR2A2	6743.0
OR8A1	6742.0
OR8K3	6715.0
OR5M9	6696.0
OR10G7	6648.0
OR1J2	6619.0
OR56A4	6607.0
OR6B1	6564.0
OR5T2	6489.0
OR9Q1	6487.0
OR10H4	6467.0
OR2D2	6420.0
OR6K6	6417.0
OR9A4	6414.0
OR13G1	6396.0
OR8H2	6349.0
OR10G9	6310.0
OR7C2	6295.0
OR6X1	6289.0
OR2F1	6286.0
OR2AE1	6274.0
OR52J3	6226.0
OR13C3	6218.0
OR8K1	6216.0
OR52N1	6199.0
OR52D1	6168.0
OR7E24	6146.0
OR1N2	6139.0
OR10H3	6078.0
OR4N5	6069.0
OR2W1	6021.0
OR7A10	5996.0
OR5P2	5984.0
OR10Q1	5970.0
OR5H2	5966.0
OR6K2	5965.0
OR5L1	5921.0
OR52A1	5920.0
OR9I1	5900.0
OR10X1	5865.0
OR5AP2	5859.0
OR2AK2	5793.0
OR2L3	5789.0
OR6C65	5774.0
OR1S2	5716.0
OR4K13	5701.0
OR1J1	5641.0
OR2B3	5636.0
OR11A1	5583.0
OR10G3	5578.0
OR2J3	5529.0
OR2G2	5515.0
OR6C75	5511.0
OR2V2	5503.0
OR6M1	5465.0
OR6C76	5455.0
OR4K1	5453.0
OR4E2	5435.0
OR7G1	5432.0
OR5A1	5427.0
OR2B6	5424.0
OR10J1	5411.0
OR56A3	5375.0
OR2M5	5359.0
OR2M7	5331.0
OR5A2	5315.0
OR12D2	5275.0
OR56B1	5255.0
OR10A6	5191.0
OR6T1	5188.0
OR5C1	5187.0
OR2T33	5174.0
OR5T3	5154.0
OR2A14	5152.0
OR51G1	5149.0
OR13C9	5102.0
OR52K1	5025.0
OR6C2	4994.0
OR7D2	4984.0
OR5I1	4982.0
OR4K5	4976.0
OR10AG1	4924.0
OR8G2	4920.0
OR2L2	4826.0
OR8B2	4816.0
OR4N2	4811.0
OR2AG1	4788.0
OR6C68	4687.0
OR5M3	4680.0
OR5R1	4642.0
OR6B2	4551.0
OR7A17	4525.0
OR9G4	4519.0
OR10H5	4482.0
OR2M3	4431.0
OR9Q2	4425.0
OR5M11	4424.0
OR52E6	4377.0
OR10G4	4361.0
OR12D3	4358.0
OR51B5	4349.0
OR1Q1	4300.0
OR2M2	4299.0
OR2D3	4289.0
OR2J2	4275.0
OR4D2	4135.0
OR2L13	4116.0
OR4A15	4064.0
OR6K3	3996.0
OR8J3	3984.0
OR10G2	3983.0
OR10K2	3980.0
OR10K1	3965.0
OR2C3	3949.0
OR2W5	3879.0
OR5K4	3799.0
OR51Q1	3738.0
OR7A5	3731.0
OR8G1	3672.0
OR2G3	3650.0
OR2T11	3639.0
OR6C70	3615.0
OR10S1	3567.0
OR8B4	3499.0
OR8D2	3397.0
OR13F1	3378.0
OR51T1	3377.0
OR6Y1	3276.0
OR52L1	3273.0
OR2H2	3180.0
OR5F1	3174.0
OR5B3	3158.0
OR52K2	3145.0
OR6C4	3139.0
OR2T6	3120.0
OR1K1	3069.0
OR9K2	3057.0
OR51B2	2998.0
OR2T1	2969.0
OR8K5	2785.0
OR3A2	2682.0
OR51A2	2577.0
OR4F15	2543.0
OR51E1	2501.0
OR6V1	2490.0
OR51I1	2415.0
OR51S1	2297.0
OR10H1	2282.0
EBF1	2152.0
OR4A47	2028.0
OR51L1	2003.0
OR4D10	1960.0
OR10A3	1850.0
OR5W2	1353.0
OR1B1	1352.0
OR4K17	1270.0
OR5B12	1094.0
OR5T1	0.5
OR10Z1	0.5
OR52A5	0.5
OR5K2	0.5
OR4A5	0.5
OR51D1	0.5
OR10W1	0.5
OR2A12	0.5
OR1I1	0.5
OR52H1	0.5
OR52E2	0.5
OR5D16	0.5
OR52B2	0.5
OR6B3	0.5
OR4C46	0.5
OR2S2	0.5
OR56A1	0.5
OR1S1	0.5
OR6N1	0.5
OR6F1	0.5
OR2A25	0.5
OR8I2	0.5
OR51V1	0.5
OR14J1	0.5
OR5H1	0.5
OR2T2	0.5
OR4F4	0.5
OR10J5	0.5
OR5D13	0.5
OR5D14	0.5
OR2T12	0.5
OR51B4	0.5
OR52E4	0.5
OR52N2	0.5
OR52N5	0.5
OR2A1	0.5
OR5K3	0.5
OR4K15	0.5
OR4C6	0.5
OR4B1	0.5
OR2K2	0.5
OR8D4	0.5
OR6S1	0.5
OR52M1	0.5
OR2T35	0.5
OR5J2	0.5
OR51G2	0.5
OR1D5	0.5
OR1D4	0.5
OR5M1	0.5
OR4D6	0.5
OR56A5	0.5
OR6C3	0.5
OR5K1	0.5
OR56B4	0.5
OR8B3	0.5
OR4C16	0.5
OR8U1	0.5
OR5AN1	0.5
OR13C4	0.5
OR4X2	0.5
OR13C2	0.5
OR8J1	0.5
OR4S1	0.5
OR4C13	0.5
OR2Y1	0.5
OR6Q1	0.5
OR4N4	0.5
OR4D9	0.5
OR5AR1	0.5
OR51F1	0.5
OR5B2	0.5
OR2W3	0.5
OR5H14	0.5
OR2F2	0.5
OR8H1	0.5
OR8G5	0.5
OR6C6	0.5
OR5AK2	0.5
OR5L2	0.5
OR10R2	0.5
OR2A4	0.5
OR52N4	0.5
OR4D5	0.5
OR2L5	0.5
OR1L4	0.5
OR1L6	0.5
OR13D1	0.5
OR2AP1	0.5
OR4K14	0.5
OR2C1	-1077.0
OR4D1	-1099.0
OR6N2	-1372.0
OR4D11	-1532.0
OR8B12	-1579.0
OR1L3	-1602.0
OR1A1	-1627.0
GNB1	-1775.0
OR4M2	-1873.0
OR2V1	-1878.0
OR1L1	-2056.0
OR52B6	-2059.0
OR5D18	-2122.0
OR4K2	-2123.0
OR5AU1	-2183.0
RTP2	-2236.0
OR10A4	-2270.0
OR2G6	-2271.0
OR10J3	-2328.0
OR10AD1	-2475.0
OR2T29	-2511.0
OR10H2	-2558.0
ANO2	-2582.0
OR4F6	-2770.0
OR4A16	-2829.0
OR13J1	-2999.0
OR5AC2	-3060.0
OR11L1	-3235.0
OR2T5	-3245.0
OR51M1	-3456.0
OR4M1	-3467.0
OR1E1	-3549.0
OR4X1	-3668.0
OR9G1	-3822.5
OR9G9	-3822.5
OR52I1	-3828.0
OR7G3	-4117.0
OR10V1	-4155.0
OR1A2	-4173.0
OR14A16	-4241.0
OR52R1	-4246.0
OR10A5	-4400.0
OR2Z1	-4600.0
OR2M4	-4666.0
OR14C36	-4769.0
OR51B6	-4881.0
OR10T2	-5043.0
OR10P1	-5110.0
OR1L8	-5279.0
OR7G2	-5335.0
OR1C1	-5538.0
OR8S1	-5621.0
OR5H6	-5700.0
OR51I2	-5714.0
OR3A1	-5799.0
OR6C74	-5941.0
OR4C12	-5950.0
OR5B17	-6005.0
OR7D4	-6047.0
OR10A7	-6305.0
OR1E2	-6338.0
OR4C15	-6367.0
OR11H6	-6375.0
CNGA4	-6448.0
OR5M10	-6556.0
OR2T4	-6581.0
OR4L1	-6679.0
ADCY3	-6749.0
OR2T3	-7086.0
OR4C45	-7637.0
OR10A2	-7807.0
OR4Q3	-7837.0
OR1F1	-8004.0
OR2T34	-8011.0
OR5P3	-8036.0
OR6P1	-8163.0
OR2B11	-8173.0
OR2T27	-8370.0
OR52W1	-8489.0
OR2AT4	-8983.0
OR3A3	-9302.0
OR1M1	-9387.0
OR4F5	-9440.0
OR14I1	-10018.0
OR10C1	-10068.0
REEP1	-11079.0
OR1G1	-12224.0
GNG13	-12471.0
OR4C3	-13127.0
CNGB1	-13485.0
GNAL	-13701.0
LHX2	-17131.0
LDB1	-17974.0

---

Folding of actin by CCT/TriC

Folding of actin by CCT/TriC

	441
set	Folding of actin by CCT/TriC
setSize	10
pANOVA	0.0044
s.dist	-0.52
p.adjustANOVA	0.0126

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACTB	-18370
CCT6A	-16234
CCT7	-16086
CCT8	-15723
CCT3	-15101
CCT6B	-15096
CCT5	-14662
CCT4	-10286
TCP1	-3658
CCT2	2167

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACTB	-18370
CCT6A	-16234
CCT7	-16086
CCT8	-15723
CCT3	-15101
CCT6B	-15096
CCT5	-14662
CCT4	-10286
TCP1	-3658
CCT2	2167

---

Crosslinking of collagen fibrils

Crosslinking of collagen fibrils

	243
set	Crosslinking of collagen fibrils
setSize	10
pANOVA	0.00445
s.dist	-0.519
p.adjustANOVA	0.0127

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LOX	-17978
LOXL3	-17904
PCOLCE	-17326
LOXL2	-16749
TLL1	-15512
TLL2	-12889
LOXL1	-11265
LOXL4	-9236
BMP1	-6572
PXDN	2475

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LOX	-17978
LOXL3	-17904
PCOLCE	-17326
LOXL2	-16749
TLL1	-15512
TLL2	-12889
LOXL1	-11265
LOXL4	-9236
BMP1	-6572
PXDN	2475

---

Translation

Translation

	1429
set	Translation
setSize	263
pANOVA	1.77e-47
s.dist	-0.517
p.adjustANOVA	3e-45

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SPCS1	-18491
MRPS18B	-18393
MRPL41	-18391
TRMT112	-18345
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
GFM2	-18256
RPL26L1	-18152
RPL23A	-18108
SRP72	-18067
RPL18	-18029
MRPS11	-18028
EIF3I	-18000
MRPL51	-17993
RPS21	-17992
AIMP1	-17990
MRPL46	-17951
EEF1B2	-17849

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SPCS1	-18491.0
MRPS18B	-18393.0
MRPL41	-18391.0
TRMT112	-18345.0
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
GFM2	-18256.0
RPL26L1	-18152.0
RPL23A	-18108.0
SRP72	-18067.0
RPL18	-18029.0
MRPS11	-18028.0
EIF3I	-18000.0
MRPL51	-17993.0
RPS21	-17992.0
AIMP1	-17990.0
MRPL46	-17951.0
EEF1B2	-17849.0
EIF3J	-17815.0
MTRF1L	-17812.0
FAU	-17763.0
RPL41	-17725.0
SRP14	-17717.0
RPS25	-17651.0
MRPS26	-17629.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
MTIF3	-17382.0
SRP54	-17345.0
MRPL17	-17331.0
RPS13	-17324.0
AURKAIP1	-17254.0
HARS2	-17248.0
RPL13	-17240.0
SEC61G	-17182.0
RPS10	-17143.0
EEF1A1	-17137.0
MRPS2	-17122.0
RPL31	-17100.0
RPS16	-17067.0
MRPS7	-17059.0
RPS23	-17014.0
RPL6	-17005.0
MRPL38	-16998.0
MRPS16	-16944.0
EIF2S2	-16852.0
RPL36	-16817.0
EIF2B4	-16802.0
MRPL49	-16785.0
MRPS12	-16777.0
OXA1L	-16745.0
EIF3K	-16720.0
DARS2	-16677.0
MRPS30	-16660.0
MARS2	-16650.0
MRPL32	-16598.0
MRPL40	-16572.0
RPS18	-16566.0
MRPL53	-16537.0
MRPL30	-16488.0
SARS2	-16482.0
RPL28	-16427.0
MRPL55	-16411.0
RPS14	-16396.0
MRPL36	-16381.0
RPL23	-16350.0
EIF5B	-16282.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
MRPS5	-16088.0
RPL26	-16076.0
MRPL54	-16000.0
RARS2	-15954.0
EIF4H	-15938.0
MRPS34	-15882.0
RPL22	-15825.0
RPL39L	-15803.0
CHCHD1	-15791.0
MRPS15	-15740.0
MRPL57	-15726.0
RPLP2	-15631.0
EIF2B2	-15615.0
SRP9	-15608.0
EEF1A2	-15575.0
MRPL37	-15540.0
EIF5	-15532.0
RPL37A	-15505.0
MRPL47	-15298.0
RPL7	-15268.0
SPCS3	-15153.0
MRPS31	-15145.0
RPL17	-15007.0
SEC11C	-14981.0
RPS27	-14914.0
MRPL43	-14902.0
RPS15	-14876.0
MRPL10	-14826.0
EEF1D	-14805.0
TUFM	-14732.0
RPL35	-14710.0
SEC61A1	-14695.0
EIF3M	-14684.0
RPL18A	-14604.0
MRPS18C	-14513.0
RPN2	-14488.0
MRPS23	-14458.0
AARS2	-14403.0
SSR3	-14297.0
RPL32	-14215.0
YARS2	-14185.0
SEC11A	-14143.0
MTFMT	-14120.0
EIF2B1	-14114.0
FARSB	-14085.0
SRP19	-14064.0
TARS2	-13998.0
MRPL50	-13972.0
RPL35A	-13949.0
RPL22L1	-13936.0
PTCD3	-13932.0
EIF4A2	-13846.0
RPS3A	-13728.0
MRPS24	-13585.0
MRPL11	-13539.0
ERAL1	-13515.0
RPS29	-13378.0
MRPS33	-13337.0
MRPS18A	-13331.0
RPL24	-13302.0
EIF3L	-13293.0
MRPL12	-13230.0
EIF4B	-13109.0
EIF4EBP1	-13068.0
MRPS10	-13036.0
RPL21	-13022.5
RPS5	-12993.0
GFM1	-12958.0
MRPL44	-12940.0
RPLP0	-12842.0
RPS28	-12739.0
RPN1	-12715.0
EIF2B5	-12663.0
MRPL4	-12597.0
MRPS9	-12505.0
MRPL3	-12280.0
RPL37	-12236.0
EIF3F	-12161.0
MRPL14	-12121.0
RPL19	-12092.0
SEC61B	-12083.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
MRPL13	-11757.0
MRPL15	-11680.0
PPA2	-11563.0
RPL30	-11458.0
MRPL24	-11369.0
EIF3B	-11318.0
AIMP2	-11310.0
MRPL2	-11290.0
RPLP1	-11260.0
RPS8	-11243.0
SPCS2	-11202.0
MRPS17	-11108.0
MRPL39	-11066.0
VARS2	-11049.0
PARS2	-10963.0
EIF2S1	-10838.0
MRPS25	-10790.0
MRPL42	-10577.0
RPS15A	-10561.0
MRPL27	-10322.0
RPL8	-10300.0
EEF1G	-10263.0
MRPL21	-10164.0
GSPT1	-10150.0
RPL9	-10147.0
RPS26	-10126.0
MRPL9	-10027.0
RPS11	-9951.0
MRPL1	-9933.0
EEF2	-9928.0
APEH	-9854.0
MRPL18	-9780.0
EIF4A1	-9770.0
MRPL33	-9729.0
RPL36AL	-9579.0
RPS12	-9472.0
MRPL52	-9393.0
MRPL23	-9350.0
DDOST	-9175.0
DAP3	-9134.0
MRRF	-9114.0
RPL34	-8988.0
RPS19	-8827.0
EIF3G	-8766.0
WARS2	-8689.0
PABPC1	-8458.0
MRPS35	-8363.0
EIF3E	-8286.0
SRPRB	-8239.0
MRPS22	-8186.0
MRPL28	-8155.0
MRPL19	-8042.0
GADD45GIP1	-7961.0
MRPS6	-7875.0
LARS2	-7827.0
RPS20	-7800.0
TRAM1	-7796.0
MRPL34	-7707.0
MRPS36	-7680.0
EARS2	-7658.0
RPL3L	-7402.0
TSFM	-7299.0
SEC61A2	-7246.0
N6AMT1	-7188.0
MRPL35	-7174.0
MRPS27	-7135.0
EIF4E	-6926.0
SSR2	-6671.0
ETF1	-6614.0
PPA1	-6594.0
MRPL20	-6324.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
MRPL16	-5712.0
MRPS28	-5568.0
EIF3A	-5427.0
EIF3C	-5008.0
RPS6	-4952.0
RPS7	-4816.0
EIF3D	-4766.0
MRPS21	-4530.0
MRPS14	-4094.0
FARSA	-3968.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
CARS2	-3122.0
MRPL22	-2713.0
MTIF2	-2456.0
RPS24	-2438.0
SRP68	-2412.0
FARS2	-1896.0
EIF3H	-1517.0
SSR1	-1169.0
RPS9	0.5
RPS17	0.5
MRPL48	1052.0
IARS2	1257.0
EIF4G1	1462.0
NARS2	2400.0
EIF2B3	2605.0
EEF1E1	3392.0
MRPL45	5801.0

---

NGF-stimulated transcription

NGF-stimulated transcription

	773
set	NGF-stimulated transcription
setSize	39
pANOVA	3.78e-08
s.dist	-0.509
p.adjustANOVA	3.42e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
JUNB	-18422
EGR3	-18410
CDK5R2	-18296
FOS	-18110
NAB2	-17760
ASCL1	-17706
FOSB	-17590
ID2	-17545
EGR1	-17280
CDK5	-17031
LYL1	-16914
REST	-16871
ID4	-16800
EGR2	-16739
SRF	-16666
ID3	-16516
ID1	-15774
DNM2	-15722
F3	-15036
FOSL1	-14916

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
JUNB	-18422
EGR3	-18410
CDK5R2	-18296
FOS	-18110
NAB2	-17760
ASCL1	-17706
FOSB	-17590
ID2	-17545
EGR1	-17280
CDK5	-17031
LYL1	-16914
REST	-16871
ID4	-16800
EGR2	-16739
SRF	-16666
ID3	-16516
ID1	-15774
DNM2	-15722
F3	-15036
FOSL1	-14916
EGR4	-14471
JUND	-13794
VGF	-13738
TF	-11899
TRIB1	-11346
ATF2	-11009
ARC	-10442
CDK5R1	-9470
RRAD	-7987
ATF1	-7277
EP300	-7133
MEF2D	-4820
NAB1	-4260
TPH1	-3536
CREB1	-2528
SGK1	-1996
CHD4	-1237
SH3GL3	-1027
TCF12	4215

---

SCF(Skp2)-mediated degradation of p27/p21

SCF(Skp2)-mediated degradation of p27/p21

	1157
set	SCF(Skp2)-mediated degradation of p27/p21
setSize	58
pANOVA	2.07e-11
s.dist	-0.508
p.adjustANOVA	3.6e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1B	-18553
RPS27A	-18298
CCND1	-17934
PSMC3	-17774
PSMB9	-17698
PSMA7	-17618
PSMB8	-17603
PSME3	-17445
PSMD13	-17429
CKS1B	-17278
PSMA5	-17225
PSMB6	-16993
PSMC5	-16781
PSMB1	-16712
PSMB5	-16664
PSMB3	-16653
PSMA4	-16560
PSME2	-16457
PSMD7	-16198
PSMA2	-15927

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1B	-18553
RPS27A	-18298
CCND1	-17934
PSMC3	-17774
PSMB9	-17698
PSMA7	-17618
PSMB8	-17603
PSME3	-17445
PSMD13	-17429
CKS1B	-17278
PSMA5	-17225
PSMB6	-16993
PSMC5	-16781
PSMB1	-16712
PSMB5	-16664
PSMB3	-16653
PSMA4	-16560
PSME2	-16457
PSMD7	-16198
PSMA2	-15927
PSMD4	-15914
CCNA1	-15733
PSMA3	-15533
PSMD3	-15315
PSMC1	-15045
PSMA6	-14837
CDK4	-14760
CCNE1	-14745
CCNA2	-14537
PSME1	-14321
PSMB10	-14160
SKP1	-13849
CCNE2	-13663
PSMD12	-13430
PSMB4	-13312
CDKN1A	-12698
UBA52	-11952
PSMC6	-11645
PSMD2	-11596
PSMC4	-11033
PSMB2	-10588
PSMD8	-10575
CUL1	-10273
SKP2	-10226
PSMC2	-9648
UBC	-9384
PSMD1	-8760
PSMA1	-7634
PSMD9	-6355
CDK2	-5005
PSMD11	-3849
PSMF1	-3225
PSMD14	-2714
PTK6	1101
PSMD6	1389
UBB	2541
PSMB7	3820
PSMD5	7174

---

SUMOylation of transcription factors

SUMOylation of transcription factors

	1186
set	SUMOylation of transcription factors
setSize	20
pANOVA	8.92e-05
s.dist	-0.506
p.adjustANOVA	0.000412

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TFAP2B	-18471
TFAP2A	-18394
TP53	-18115
HIC1	-18042
FOXL2	-17769
SUMO2	-17567
PIAS3	-17089
CDKN2A	-15805
SP3	-15481
PIAS4	-13250
SUMO1	-13076
PIAS2	-12132
TFAP2C	-11452
TP53BP1	-11248
MTA1	-10675
UBE2I	-9524
PIAS1	-7433
SUMO3	-4815
MITF	3609
MDM2	4367

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TFAP2B	-18471
TFAP2A	-18394
TP53	-18115
HIC1	-18042
FOXL2	-17769
SUMO2	-17567
PIAS3	-17089
CDKN2A	-15805
SP3	-15481
PIAS4	-13250
SUMO1	-13076
PIAS2	-12132
TFAP2C	-11452
TP53BP1	-11248
MTA1	-10675
UBE2I	-9524
PIAS1	-7433
SUMO3	-4815
MITF	3609
MDM2	4367

---

Purine ribonucleoside monophosphate biosynthesis

Purine ribonucleoside monophosphate biosynthesis

	969
set	Purine ribonucleoside monophosphate biosynthesis
setSize	11
pANOVA	0.00381
s.dist	-0.504
p.adjustANOVA	0.0111

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PAICS	-17924
ADSL	-15100
PPAT	-14693
IMPDH1	-12949
PFAS	-12391
GMPS	-12309
GART	-12274
ADSSL1	-11862
ATIC	-10231
ADSS	-8384
IMPDH2	-4888

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PAICS	-17924
ADSL	-15100
PPAT	-14693
IMPDH1	-12949
PFAS	-12391
GMPS	-12309
GART	-12274
ADSSL1	-11862
ATIC	-10231
ADSS	-8384
IMPDH2	-4888

---

Interaction With Cumulus Cells And The Zona Pellucida

Interaction With Cumulus Cells And The Zona Pellucida

	611
set	Interaction With Cumulus Cells And The Zona Pellucida
setSize	11
pANOVA	0.00424
s.dist	0.498
p.adjustANOVA	0.0122

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADAM30	7127.0
ADAM2	5574.0
SPAM1	5030.0
OVGP1	4458.0
ZP4	4209.0
ZP2	3393.0
ADAM20	2345.0
ADAM21	0.5
ZP3	-2702.0
B4GALT1	-5064.0
ZP1	-13409.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADAM30	7127.0
ADAM2	5574.0
SPAM1	5030.0
OVGP1	4458.0
ZP4	4209.0
ZP2	3393.0
ADAM20	2345.0
ADAM21	0.5
ZP3	-2702.0
B4GALT1	-5064.0
ZP1	-13409.0

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

	821
set	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize	108
pANOVA	5.33e-19
s.dist	-0.495
p.adjustANOVA	1.77e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
PNRC2	-18325
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
RPS21	-17992
SMG7	-17856
FAU	-17763
RPL41	-17725
RPS25	-17651
NCBP1	-17533
RPS2	-17524
RPL11	-17518
RPL27	-17446
PPP2CA	-17436
RPL14	-17403
RPS13	-17324

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
PNRC2	-18325.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
RPS21	-17992.0
SMG7	-17856.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
NCBP1	-17533.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
PPP2CA	-17436.0
RPL14	-17403.0
RPS13	-17324.0
PPP2R1A	-17243.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
RPL36	-16817.0
MAGOH	-16756.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
UPF3A	-15567.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
RPL18A	-14604.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
RBM8A	-13812.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
MAGOHB	-10713.0
RPS15A	-10561.0
RPL8	-10300.0
GSPT1	-10150.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
DCP1A	-9817.0
RPL36AL	-9579.0
RPS12	-9472.0
PPP2R2A	-9418.0
RPL34	-8988.0
RPS19	-8827.0
SMG8	-8785.0
PABPC1	-8458.0
RPS20	-7800.0
SMG1	-7571.0
RPL3L	-7402.0
UPF2	-7298.0
ETF1	-6614.0
RPL3	-6287.0
SMG6	-6267.0
RPL38	-6212.0
NCBP2	-5801.0
RPL7A	-5788.0
EIF4A3	-5711.0
RNPS1	-5454.0
RPS6	-4952.0
RPS7	-4816.0
CASC3	-3952.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
RPS9	0.5
RPS17	0.5
EIF4G1	1462.0
UPF1	1808.0
SMG5	2510.0
SMG9	7027.0

---

Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)

	823
set	Nonsense-Mediated Decay (NMD)
setSize	108
pANOVA	5.33e-19
s.dist	-0.495
p.adjustANOVA	1.77e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
PNRC2	-18325
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
RPS21	-17992
SMG7	-17856
FAU	-17763
RPL41	-17725
RPS25	-17651
NCBP1	-17533
RPS2	-17524
RPL11	-17518
RPL27	-17446
PPP2CA	-17436
RPL14	-17403
RPS13	-17324

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
PNRC2	-18325.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
RPS21	-17992.0
SMG7	-17856.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
NCBP1	-17533.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
PPP2CA	-17436.0
RPL14	-17403.0
RPS13	-17324.0
PPP2R1A	-17243.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
RPL36	-16817.0
MAGOH	-16756.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
UPF3A	-15567.0
RPL37A	-15505.0
RPL7	-15268.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
RPL35	-14710.0
RPL18A	-14604.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
RBM8A	-13812.0
RPS3A	-13728.0
RPS29	-13378.0
RPL24	-13302.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
MAGOHB	-10713.0
RPS15A	-10561.0
RPL8	-10300.0
GSPT1	-10150.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
DCP1A	-9817.0
RPL36AL	-9579.0
RPS12	-9472.0
PPP2R2A	-9418.0
RPL34	-8988.0
RPS19	-8827.0
SMG8	-8785.0
PABPC1	-8458.0
RPS20	-7800.0
SMG1	-7571.0
RPL3L	-7402.0
UPF2	-7298.0
ETF1	-6614.0
RPL3	-6287.0
SMG6	-6267.0
RPL38	-6212.0
NCBP2	-5801.0
RPL7A	-5788.0
EIF4A3	-5711.0
RNPS1	-5454.0
RPS6	-4952.0
RPS7	-4816.0
CASC3	-3952.0
RPL4	-3850.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
RPS9	0.5
RPS17	0.5
EIF4G1	1462.0
UPF1	1808.0
SMG5	2510.0
SMG9	7027.0

---

Negative regulation of activity of TFAP2 (AP-2) family transcription factors

Negative regulation of activity of TFAP2 (AP-2) family transcription factors

	802
set	Negative regulation of activity of TFAP2 (AP-2) family transcription factors
setSize	10
pANOVA	0.0067
s.dist	-0.495
p.adjustANOVA	0.0178

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TFAP2B	-18471
TFAP2A	-18394
TFAP2D	-18357
TFAP2E	-17907
KCTD1	-14503
SUMO1	-13076
TFAP2C	-11452
UBE2I	-9524
KCTD15	-4011
WWOX	5914

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TFAP2B	-18471
TFAP2A	-18394
TFAP2D	-18357
TFAP2E	-17907
KCTD1	-14503
SUMO1	-13076
TFAP2C	-11452
UBE2I	-9524
KCTD15	-4011
WWOX	5914

---

NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus

	781
set	NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize	11
pANOVA	0.00466
s.dist	-0.493
p.adjustANOVA	0.0131

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSENEN	-18212
DLL4	-17645
JAG1	-17419
APH1A	-15861
YWHAZ	-14965
APH1B	-12218
PSEN2	-9612
NOTCH4	-8521
NCSTN	-8029
PSEN1	-5975
ADAM10	-2957

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSENEN	-18212
DLL4	-17645
JAG1	-17419
APH1A	-15861
YWHAZ	-14965
APH1B	-12218
PSEN2	-9612
NOTCH4	-8521
NCSTN	-8029
PSEN1	-5975
ADAM10	-2957

---

Pexophagy

Pexophagy

	903
set	Pexophagy
setSize	11
pANOVA	0.00483
s.dist	-0.491
p.adjustANOVA	0.0136

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-18298
NBR1	-18244
MAP1LC3B	-16917
SQSTM1	-16835
PEX5	-16267
ATM	-16240
UBA52	-11952
UBC	-9384
EPAS1	-4832
USP30	-4689
UBB	2541

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-18298
NBR1	-18244
MAP1LC3B	-16917
SQSTM1	-16835
PEX5	-16267
ATM	-16240
UBA52	-11952
UBC	-9384
EPAS1	-4832
USP30	-4689
UBB	2541

---

FOXO-mediated transcription of cell cycle genes

FOXO-mediated transcription of cell cycle genes

	426
set	FOXO-mediated transcription of cell cycle genes
setSize	16
pANOVA	0.000741
s.dist	-0.487
p.adjustANOVA	0.00264

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CDKN1B	-18553
FOXG1	-16934
BTG1	-16456
GADD45A	-15017
CCNG2	-14944
KLF4	-14561
CAV1	-14206
RBL2	-13530
PCBP4	-13158
CDKN1A	-12698
SMAD2	-12347
SMAD3	-9463
FOXO3	-8861
SMAD4	-7562
MSTN	-5328
FOXO1	3659

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CDKN1B	-18553
FOXG1	-16934
BTG1	-16456
GADD45A	-15017
CCNG2	-14944
KLF4	-14561
CAV1	-14206
RBL2	-13530
PCBP4	-13158
CDKN1A	-12698
SMAD2	-12347
SMAD3	-9463
FOXO3	-8861
SMAD4	-7562
MSTN	-5328
FOXO1	3659

---

Interleukin-2 signaling

Interleukin-2 signaling

	628
set	Interleukin-2 signaling
setSize	11
pANOVA	0.00516
s.dist	-0.487
p.adjustANOVA	0.0143

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAT5A	-17358
SHC1	-17113
LCK	-15687
STAT5B	-14273
PTK2B	-14246
IL2RB	-13468
JAK1	-12242
SYK	-9905
JAK3	-9359
IL2	-8415
IL2RA	1472

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAT5A	-17358
SHC1	-17113
LCK	-15687
STAT5B	-14273
PTK2B	-14246
IL2RB	-13468
JAK1	-12242
SYK	-9905
JAK3	-9359
IL2	-8415
IL2RA	1472

---

Inhibition of DNA recombination at telomere

Inhibition of DNA recombination at telomere

	596
set	Inhibition of DNA recombination at telomere
setSize	20
pANOVA	0.000166
s.dist	-0.486
p.adjustANOVA	0.000704

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TERF2IP	-18164.0
POLR2I	-17273.0
TINF2	-16868.0
POLR2H	-15949.0
H2AFX	-15693.0
POLR2A	-15680.0
POLR2L	-15396.0
POLR2E	-15178.0
DAXX	-14966.0
POLR2D	-14586.0
POLR2K	-13458.0
POLR2C	-12922.0
ACD	-12613.5
POLR2F	-11581.0
POLR2B	-10688.0
POLR2G	-7478.0
POT1	-5891.0
TERF1	-3875.0
POLR2J	-1824.0
TERF2	2850.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TERF2IP	-18164.0
POLR2I	-17273.0
TINF2	-16868.0
POLR2H	-15949.0
H2AFX	-15693.0
POLR2A	-15680.0
POLR2L	-15396.0
POLR2E	-15178.0
DAXX	-14966.0
POLR2D	-14586.0
POLR2K	-13458.0
POLR2C	-12922.0
ACD	-12613.5
POLR2F	-11581.0
POLR2B	-10688.0
POLR2G	-7478.0
POT1	-5891.0
TERF1	-3875.0
POLR2J	-1824.0
TERF2	2850.0

---

Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication

	594
set	Influenza Viral RNA Transcription and Replication
setSize	129
pANOVA	1.97e-21
s.dist	-0.484
p.adjustANOVA	9.13e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
RPL18	-18029
RPS21	-17992
FAU	-17763
RPL41	-17725
RPS25	-17651
RPS2	-17524
RPL11	-17518
RPL27	-17446
RPL14	-17403
RPS13	-17324
POLR2I	-17273
RPL13	-17240
RPS10	-17143
RPL31	-17100

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
RPL18	-18029.0
RPS21	-17992.0
FAU	-17763.0
RPL41	-17725.0
RPS25	-17651.0
RPS2	-17524.0
RPL11	-17518.0
RPL27	-17446.0
RPL14	-17403.0
RPS13	-17324.0
POLR2I	-17273.0
RPL13	-17240.0
RPS10	-17143.0
RPL31	-17100.0
RPS16	-17067.0
NUP88	-17042.0
RPS23	-17014.0
RPL6	-17005.0
NUP37	-16879.0
RPL36	-16817.0
RPS18	-16566.0
RPL28	-16427.0
RPS14	-16396.0
NUP153	-16394.0
SEH1L	-16356.0
RPL23	-16350.0
RPL12	-16218.0
POM121	-16212.0
RPL10A	-16158.0
HSP90AA1	-16118.0
RPL29	-16110.0
RPL26	-16076.0
POLR2H	-15949.0
RPL22	-15825.0
RPL39L	-15803.0
NUP155	-15716.0
POLR2A	-15680.0
RPLP2	-15631.0
RPL37A	-15505.0
POLR2L	-15396.0
RPL7	-15268.0
POLR2E	-15178.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
NUP62	-14839.0
RPL35	-14710.0
RPL18A	-14604.0
DNAJC3	-14594.0
POLR2D	-14586.0
GTF2F1	-14352.0
RPL32	-14215.0
RPL35A	-13949.0
RPL22L1	-13936.0
RPS3A	-13728.0
POLR2K	-13458.0
RPS29	-13378.0
RPL24	-13302.0
NUP188	-13260.0
TPR	-13255.0
GRSF1	-13222.0
RPL21	-13022.5
RPS5	-12993.0
POLR2C	-12922.0
NUP85	-12862.0
RPLP0	-12842.0
RPS28	-12739.0
NUP205	-12461.0
RPL37	-12236.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
NUP160	-11799.0
POLR2F	-11581.0
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
RAE1	-10995.0
RANBP2	-10734.0
POLR2B	-10688.0
RPS15A	-10561.0
RPL8	-10300.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
NUP43	-9827.0
POM121C	-9605.0
RPL36AL	-9579.0
RPS12	-9472.0
NUP50	-9256.0
NUP133	-9195.0
RPL34	-8988.0
NUP35	-8887.0
RPS19	-8827.0
NUP107	-8403.0
RPS20	-7800.0
POLR2G	-7478.0
RPL3L	-7402.0
RPL3	-6287.0
RPL38	-6212.0
RPL7A	-5788.0
GTF2F2	-5605.0
RPS6	-4952.0
RPS7	-4816.0
AAAS	-3860.0
RPL4	-3850.0
NUP54	-3797.0
RPL5	-3670.0
RPS3	-3533.0
RPL10L	-3163.0
RPS24	-2438.0
NUP98	-2259.0
POLR2J	-1824.0
PARP1	-1631.0
RPS9	0.5
RPS17	0.5
NUP93	1753.0
NUP214	2213.0
SEC13	3177.0
NUP210	3705.0
NDC1	4585.0
IPO5	6874.0

---

Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs

	1105
set	Regulation of expression of SLITs and ROBOs
setSize	159
pANOVA	6.09e-26
s.dist	-0.483
p.adjustANOVA	4.65e-24

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LHX9	-18568
HOXA2	-18461
RPL27A	-18337
RPS27A	-18298
RPL15	-18291
RPS27L	-18269
RPL26L1	-18152
RPL23A	-18108
ISL1	-18085
RPL18	-18029
RPS21	-17992
LDB1	-17974
PSMC3	-17774
FAU	-17763
RPL41	-17725
PSMB9	-17698
RPS25	-17651
PSMA7	-17618
PSMB8	-17603
NCBP1	-17533

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LHX9	-18568.0
HOXA2	-18461.0
RPL27A	-18337.0
RPS27A	-18298.0
RPL15	-18291.0
RPS27L	-18269.0
RPL26L1	-18152.0
RPL23A	-18108.0
ISL1	-18085.0
RPL18	-18029.0
RPS21	-17992.0
LDB1	-17974.0
PSMC3	-17774.0
FAU	-17763.0
RPL41	-17725.0
PSMB9	-17698.0
RPS25	-17651.0
PSMA7	-17618.0
PSMB8	-17603.0
NCBP1	-17533.0
RPS2	-17524.0
RPL11	-17518.0
MSI1	-17513.0
RPL27	-17446.0
PSME3	-17445.0
LHX4	-17442.0
PSMD13	-17429.0
RPL14	-17403.0
RPS13	-17324.0
RPL13	-17240.0
PSMA5	-17225.0
RPS10	-17143.0
LHX2	-17131.0
RPL31	-17100.0
RPS16	-17067.0
RPS23	-17014.0
RPL6	-17005.0
PSMB6	-16993.0
RPL36	-16817.0
PSMC5	-16781.0
MAGOH	-16756.0
PSMB1	-16712.0
PSMB5	-16664.0
PSMB3	-16653.0
RPS18	-16566.0
PSMA4	-16560.0
PSME2	-16457.0
RPL28	-16427.0
RPS14	-16396.0
RPL23	-16350.0
RPL12	-16218.0
PSMD7	-16198.0
RPL10A	-16158.0
RPL29	-16110.0
RPL26	-16076.0
PSMA2	-15927.0
PSMD4	-15914.0
RPL22	-15825.0
RPL39L	-15803.0
RPLP2	-15631.0
UPF3A	-15567.0
PSMA3	-15533.0
RPL37A	-15505.0
PSMD3	-15315.0
RPL7	-15268.0
PSMC1	-15045.0
RPL17	-15007.0
RPS27	-14914.0
RPS15	-14876.0
PSMA6	-14837.0
RPL35	-14710.0
RPL18A	-14604.0
PSME1	-14321.0
RPL32	-14215.0
PSMB10	-14160.0
RPL35A	-13949.0
RPL22L1	-13936.0
RBM8A	-13812.0
RPS3A	-13728.0
ROBO3	-13685.0
PSMD12	-13430.0
RPS29	-13378.0
PSMB4	-13312.0
RPL24	-13302.0
RPL21	-13022.5
RPS5	-12993.0
RPLP0	-12842.0
RPS28	-12739.0
RPL37	-12236.0
RPL19	-12092.0
RPSA	-12049.0
UBA52	-11952.0
RPL13A	-11828.5
PSMC6	-11645.0
PSMD2	-11596.0
RPL30	-11458.0
RPLP1	-11260.0
RPS8	-11243.0
PSMC4	-11033.0
MAGOHB	-10713.0
USP33	-10630.0
PSMB2	-10588.0
PSMD8	-10575.0
RPS15A	-10561.0
RPL8	-10300.0
GSPT1	-10150.0
RPL9	-10147.0
RPS26	-10126.0
RPS11	-9951.0
SLIT1	-9797.0
CUL2	-9750.0
PSMC2	-9648.0
RPL36AL	-9579.0
RPS12	-9472.0
UBC	-9384.0
RPL34	-8988.0
RPS19	-8827.0
PSMD1	-8760.0
RBX1	-8465.0
PABPC1	-8458.0
RPS20	-7800.0
PSMA1	-7634.0
RPL3L	-7402.0
UPF2	-7298.0
PSME4	-7237.0
ETF1	-6614.0
PSMD9	-6355.0
RPL3	-6287.0
RPL38	-6212.0
NCBP2	-5801.0
RPL7A	-5788.0
EIF4A3	-5711.0
RNPS1	-5454.0
RPS6	-4952.0
DAG1	-4852.0
RPS7	-4816.0
ROBO1	-4000.0
CASC3	-3952.0
RPL4	-3850.0
PSMD11	-3849.0
RPL5	-3670.0
RPS3	-3533.0
PSMF1	-3225.0
RPL10L	-3163.0
PSMD14	-2714.0
ZSWIM8	-2677.0
RPS24	-2438.0
PSMB11	-1972.0
ROBO2	-1165.0
RPS9	0.5
RPS17	0.5
PSMD6	1389.0
EIF4G1	1462.0
SLIT2	1598.0
LHX3	1824.0
UBB	2541.0
PSMB7	3820.0
PSMD5	7174.0
PSMA8	7531.0

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

	455
set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	47
pANOVA	1.29e-08
s.dist	-0.479
p.adjustANOVA	1.28e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27A	-18298
RPS27L	-18269
EIF3I	-18000
RPS21	-17992
EIF3J	-17815
FAU	-17763
RPS25	-17651
RPS2	-17524
RPS13	-17324
RPS10	-17143
RPS16	-17067
RPS23	-17014
EIF2S2	-16852
EIF3K	-16720
RPS18	-16566
RPS14	-16396
RPS27	-14914
RPS15	-14876
EIF3M	-14684
RPS3A	-13728

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27A	-18298.0
RPS27L	-18269.0
EIF3I	-18000.0
RPS21	-17992.0
EIF3J	-17815.0
FAU	-17763.0
RPS25	-17651.0
RPS2	-17524.0
RPS13	-17324.0
RPS10	-17143.0
RPS16	-17067.0
RPS23	-17014.0
EIF2S2	-16852.0
EIF3K	-16720.0
RPS18	-16566.0
RPS14	-16396.0
RPS27	-14914.0
RPS15	-14876.0
EIF3M	-14684.0
RPS3A	-13728.0
RPS29	-13378.0
EIF3L	-13293.0
RPS5	-12993.0
RPS28	-12739.0
EIF3F	-12161.0
RPSA	-12049.0
EIF3B	-11318.0
RPS8	-11243.0
EIF2S1	-10838.0
RPS15A	-10561.0
RPS26	-10126.0
RPS11	-9951.0
RPS12	-9472.0
RPS19	-8827.0
EIF3G	-8766.0
EIF3E	-8286.0
RPS20	-7800.0
EIF3A	-5427.0
EIF3C	-5008.0
RPS6	-4952.0
RPS7	-4816.0
EIF3D	-4766.0
RPS3	-3533.0
RPS24	-2438.0
EIF3H	-1517.0
RPS9	0.5
RPS17	0.5

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report