Mitch Report

date generated: 2022-05-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             metric
## PDE4D   -11.973717
## DAB1    -11.614000
## PCDHGA1   5.901466
## HOXC4   -11.363650
## LPP      -6.110680
## PTPRN2   -2.331781

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2546
num_genes_in_profile	26148
duplicated_genes_present	0
num_profile_genes_in_sets	10252
num_profile_genes_not_in_sets	15896

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2546
num_genesets_excluded	1018
num_genesets_included	1528

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Folding of actin by CCT/TriC	10	2.12e-04	-0.676	8.52e-04
FOXO-mediated transcription of cell cycle genes	16	1.18e-05	-0.632	8.23e-05
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	6.00e-04	-0.597	1.99e-03
Repression of WNT target genes	13	3.20e-04	-0.576	1.20e-03
Crosslinking of collagen fibrils	10	2.15e-03	-0.560	5.89e-03
Processing of Intronless Pre-mRNAs	19	2.36e-05	-0.560	1.41e-04
Disorders of Developmental Biology	11	2.04e-03	-0.537	5.65e-03
Disorders of Nervous System Development	11	2.04e-03	-0.537	5.65e-03
Loss of function of MECP2 in Rett syndrome	11	2.04e-03	-0.537	5.65e-03
Pervasive developmental disorders	11	2.04e-03	-0.537	5.65e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	3.31e-03	-0.536	8.35e-03
Transcriptional regulation of testis differentiation	12	1.52e-03	-0.529	4.47e-03
Beta defensins	32	2.31e-07	0.528	2.70e-06
Regulated proteolysis of p75NTR	11	2.50e-03	-0.526	6.65e-03
Diseases associated with glycosylation precursor biosynthesis	15	4.33e-04	-0.525	1.53e-03
Processing of Capped Intronless Pre-mRNA	28	1.57e-06	-0.524	1.59e-05
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	7.00e-04	-0.523	2.25e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	2.75e-03	-0.521	7.22e-03
Beta-catenin phosphorylation cascade	16	3.30e-04	-0.518	1.23e-03
Defensins	40	1.96e-08	0.513	2.98e-07
Physiological factors	12	2.49e-03	-0.504	6.64e-03
SLBP independent Processing of Histone Pre-mRNAs	10	7.21e-03	-0.491	1.62e-02
Signaling by FGFR2 IIIa TM	19	2.14e-04	-0.490	8.52e-04
Signaling by PDGFRA extracellular domain mutants	12	4.00e-03	-0.480	9.79e-03
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	4.00e-03	-0.480	9.79e-03
MET receptor recycling	10	9.46e-03	-0.474	2.05e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	3.13e-03	-0.473	8.03e-03
CTNNB1 S33 mutants aren’t phosphorylated	14	2.19e-03	-0.473	5.94e-03
CTNNB1 S37 mutants aren’t phosphorylated	14	2.19e-03	-0.473	5.94e-03
CTNNB1 S45 mutants aren’t phosphorylated	14	2.19e-03	-0.473	5.94e-03
CTNNB1 T41 mutants aren’t phosphorylated	14	2.19e-03	-0.473	5.94e-03
Signaling by CTNNB1 phospho-site mutants	14	2.19e-03	-0.473	5.94e-03
Signaling by GSK3beta mutants	14	2.19e-03	-0.473	5.94e-03
Antimicrobial peptides	82	3.37e-13	0.464	1.01e-11
RAF-independent MAPK1/3 activation	22	1.65e-04	-0.464	6.83e-04
RUNX3 regulates p14-ARF	10	1.15e-02	-0.461	2.41e-02
RUNX2 regulates bone development	29	1.96e-05	-0.458	1.24e-04
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	6.09e-03	-0.457	1.40e-02
alpha-linolenic acid (ALA) metabolism	12	6.09e-03	-0.457	1.40e-02
RUNX2 regulates osteoblast differentiation	22	2.13e-04	-0.456	8.52e-04
APC truncation mutants have impaired AXIN binding	13	4.45e-03	-0.455	1.07e-02
AXIN missense mutants destabilize the destruction complex	13	4.45e-03	-0.455	1.07e-02
Signaling by AMER1 mutants	13	4.45e-03	-0.455	1.07e-02
Signaling by APC mutants	13	4.45e-03	-0.455	1.07e-02
Signaling by AXIN mutants	13	4.45e-03	-0.455	1.07e-02
Truncations of AMER1 destabilize the destruction complex	13	4.45e-03	-0.455	1.07e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	4.18e-05	-0.455	2.23e-04
Nephrin family interactions	21	3.31e-04	-0.452	1.23e-03
Cleavage of the damaged purine	11	9.51e-03	-0.451	2.06e-02
Depurination	11	9.51e-03	-0.451	2.06e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Folding of actin by CCT/TriC	10	2.12e-04	-0.676000	8.52e-04
FOXO-mediated transcription of cell cycle genes	16	1.18e-05	-0.632000	8.23e-05
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	6.00e-04	-0.597000	1.99e-03
Repression of WNT target genes	13	3.20e-04	-0.576000	1.20e-03
Crosslinking of collagen fibrils	10	2.15e-03	-0.560000	5.89e-03
Processing of Intronless Pre-mRNAs	19	2.36e-05	-0.560000	1.41e-04
Disorders of Developmental Biology	11	2.04e-03	-0.537000	5.65e-03
Disorders of Nervous System Development	11	2.04e-03	-0.537000	5.65e-03
Loss of function of MECP2 in Rett syndrome	11	2.04e-03	-0.537000	5.65e-03
Pervasive developmental disorders	11	2.04e-03	-0.537000	5.65e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	3.31e-03	-0.536000	8.35e-03
Transcriptional regulation of testis differentiation	12	1.52e-03	-0.529000	4.47e-03
Beta defensins	32	2.31e-07	0.528000	2.70e-06
Regulated proteolysis of p75NTR	11	2.50e-03	-0.526000	6.65e-03
Diseases associated with glycosylation precursor biosynthesis	15	4.33e-04	-0.525000	1.53e-03
Processing of Capped Intronless Pre-mRNA	28	1.57e-06	-0.524000	1.59e-05
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	7.00e-04	-0.523000	2.25e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	2.75e-03	-0.521000	7.22e-03
Beta-catenin phosphorylation cascade	16	3.30e-04	-0.518000	1.23e-03
Defensins	40	1.96e-08	0.513000	2.98e-07
Physiological factors	12	2.49e-03	-0.504000	6.64e-03
SLBP independent Processing of Histone Pre-mRNAs	10	7.21e-03	-0.491000	1.62e-02
Signaling by FGFR2 IIIa TM	19	2.14e-04	-0.490000	8.52e-04
Signaling by PDGFRA extracellular domain mutants	12	4.00e-03	-0.480000	9.79e-03
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	4.00e-03	-0.480000	9.79e-03
MET receptor recycling	10	9.46e-03	-0.474000	2.05e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	3.13e-03	-0.473000	8.03e-03
CTNNB1 S33 mutants aren’t phosphorylated	14	2.19e-03	-0.473000	5.94e-03
CTNNB1 S37 mutants aren’t phosphorylated	14	2.19e-03	-0.473000	5.94e-03
CTNNB1 S45 mutants aren’t phosphorylated	14	2.19e-03	-0.473000	5.94e-03
CTNNB1 T41 mutants aren’t phosphorylated	14	2.19e-03	-0.473000	5.94e-03
Signaling by CTNNB1 phospho-site mutants	14	2.19e-03	-0.473000	5.94e-03
Signaling by GSK3beta mutants	14	2.19e-03	-0.473000	5.94e-03
Antimicrobial peptides	82	3.37e-13	0.464000	1.01e-11
RAF-independent MAPK1/3 activation	22	1.65e-04	-0.464000	6.83e-04
RUNX3 regulates p14-ARF	10	1.15e-02	-0.461000	2.41e-02
RUNX2 regulates bone development	29	1.96e-05	-0.458000	1.24e-04
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	6.09e-03	-0.457000	1.40e-02
alpha-linolenic acid (ALA) metabolism	12	6.09e-03	-0.457000	1.40e-02
RUNX2 regulates osteoblast differentiation	22	2.13e-04	-0.456000	8.52e-04
APC truncation mutants have impaired AXIN binding	13	4.45e-03	-0.455000	1.07e-02
AXIN missense mutants destabilize the destruction complex	13	4.45e-03	-0.455000	1.07e-02
Signaling by AMER1 mutants	13	4.45e-03	-0.455000	1.07e-02
Signaling by APC mutants	13	4.45e-03	-0.455000	1.07e-02
Signaling by AXIN mutants	13	4.45e-03	-0.455000	1.07e-02
Truncations of AMER1 destabilize the destruction complex	13	4.45e-03	-0.455000	1.07e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	4.18e-05	-0.455000	2.23e-04
Nephrin family interactions	21	3.31e-04	-0.452000	1.23e-03
Cleavage of the damaged purine	11	9.51e-03	-0.451000	2.06e-02
Depurination	11	9.51e-03	-0.451000	2.06e-02
Recognition and association of DNA glycosylase with site containing an affected purine	11	9.51e-03	-0.451000	2.06e-02
RNA Polymerase III Transcription Termination	23	1.91e-04	-0.449000	7.77e-04
Glucocorticoid biosynthesis	10	1.39e-02	0.449000	2.83e-02
FGFR2 alternative splicing	26	7.40e-05	-0.449000	3.53e-04
mRNA Capping	28	5.87e-05	-0.438000	2.98e-04
RNA Polymerase III Chain Elongation	18	1.34e-03	-0.436000	4.01e-03
SUMOylation of immune response proteins	10	1.69e-02	-0.436000	3.33e-02
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	9.04e-03	-0.435000	1.97e-02
Condensation of Prophase Chromosomes	12	9.07e-03	-0.435000	1.97e-02
Uptake and function of anthrax toxins	11	1.33e-02	-0.431000	2.73e-02
Base-Excision Repair, AP Site Formation	18	1.73e-03	-0.426000	5.00e-03
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	1.01e-04	-0.424000	4.60e-04
Polymerase switching on the C-strand of the telomere	24	3.27e-04	-0.423000	1.22e-03
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	1.11e-02	-0.423000	2.35e-02
Defective EXT2 causes exostoses 2	12	1.11e-02	-0.423000	2.35e-02
Endosomal/Vacuolar pathway	12	1.12e-02	-0.423000	2.37e-02
Mitochondrial tRNA aminoacylation	18	2.03e-03	-0.420000	5.65e-03
Early Phase of HIV Life Cycle	14	6.61e-03	-0.419000	1.50e-02
ERK/MAPK targets	20	1.18e-03	-0.419000	3.60e-03
NGF-stimulated transcription	39	5.99e-06	-0.419000	4.77e-05
Initiation of Nuclear Envelope (NE) Reformation	18	2.12e-03	-0.418000	5.83e-03
tRNA Aminoacylation	24	3.92e-04	-0.418000	1.41e-03
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	5.30e-03	-0.416000	1.24e-02
HS-GAG biosynthesis	28	1.42e-04	-0.415000	6.09e-04
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	1.09e-04	-0.415000	4.90e-04
RHO GTPases Activate Formins	114	1.89e-14	-0.415000	7.03e-13
Transport of Mature mRNAs Derived from Intronless Transcripts	41	4.29e-06	-0.415000	3.79e-05
Expression and translocation of olfactory receptors	365	5.99e-42	0.412000	1.31e-39
Acetylcholine Neurotransmitter Release Cycle	16	4.32e-03	-0.412000	1.05e-02
Resolution of Sister Chromatid Cohesion	98	1.86e-12	-0.411000	5.08e-11
Signaling by ALK	26	2.84e-04	-0.411000	1.08e-03
Association of TriC/CCT with target proteins during biosynthesis	38	1.21e-05	-0.410000	8.33e-05
Serotonin Neurotransmitter Release Cycle	16	4.54e-03	-0.410000	1.09e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	22	8.89e-04	-0.409000	2.76e-03
Neurodegenerative Diseases	22	8.89e-04	-0.409000	2.76e-03
RMTs methylate histone arginines	29	1.38e-04	-0.409000	5.99e-04
Activation of HOX genes during differentiation	61	3.54e-08	-0.408000	5.20e-07
Activation of anterior HOX genes in hindbrain development during early embryogenesis	61	3.54e-08	-0.408000	5.20e-07
DARPP-32 events	24	5.44e-04	-0.408000	1.85e-03
RNA Pol II CTD phosphorylation and interaction with CE	26	3.32e-04	-0.406000	1.23e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	3.32e-04	-0.406000	1.23e-03
eNOS activation	11	2.01e-02	-0.405000	3.83e-02
Transport of Mature mRNA Derived from an Intronless Transcript	40	9.57e-06	-0.404000	7.00e-05
EGR2 and SOX10-mediated initiation of Schwann cell myelination	27	2.93e-04	-0.402000	1.11e-03
Dopamine Neurotransmitter Release Cycle	20	1.83e-03	-0.402000	5.25e-03
Nuclear Events (kinase and transcription factor activation)	60	7.10e-08	-0.402000	9.60e-07
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	89	6.02e-11	-0.401000	1.31e-09
Amplification of signal from the kinetochores	89	6.02e-11	-0.401000	1.31e-09
Signaling by PDGFR in disease	20	1.91e-03	-0.401000	5.42e-03
ERKs are inactivated	13	1.24e-02	-0.400000	2.56e-02
Cleavage of the damaged pyrimidine	16	5.55e-03	-0.400000	1.29e-02
Depyrimidination	16	5.55e-03	-0.400000	1.29e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	5.55e-03	-0.400000	1.29e-02
Leading Strand Synthesis	13	1.25e-02	-0.400000	2.58e-02
Polymerase switching	13	1.25e-02	-0.400000	2.58e-02
Olfactory Signaling Pathway	372	6.84e-40	0.398000	1.16e-37
Signaling by WNT in cancer	32	9.81e-05	-0.398000	4.51e-04
Inhibition of DNA recombination at telomere	20	2.07e-03	-0.398000	5.72e-03
EPH-ephrin mediated repulsion of cells	48	2.11e-06	-0.395000	2.02e-05
Cyclin A/B1/B2 associated events during G2/M transition	24	8.05e-04	-0.395000	2.54e-03
RND1 GTPase cycle	41	1.24e-05	-0.394000	8.53e-05
EML4 and NUDC in mitotic spindle formation	93	4.92e-11	-0.394000	1.16e-09
Signaling by FGFR2 in disease	42	1.01e-05	-0.394000	7.28e-05
Interactions of Vpr with host cellular proteins	33	9.22e-05	-0.393000	4.30e-04
RET signaling	41	1.33e-05	-0.393000	9.01e-05
Diseases associated with N-glycosylation of proteins	19	3.04e-03	-0.393000	7.87e-03
HDMs demethylate histones	18	3.94e-03	-0.392000	9.69e-03
PI-3K cascade:FGFR4	19	3.09e-03	-0.392000	7.97e-03
Vpr-mediated nuclear import of PICs	32	1.35e-04	-0.390000	5.88e-04
Role of LAT2/NTAL/LAB on calcium mobilization	13	1.50e-02	-0.389000	3.02e-02
Sulfur amino acid metabolism	27	4.82e-04	-0.388000	1.67e-03
Interleukin-27 signaling	11	2.69e-02	-0.385000	4.90e-02
Downstream signaling of activated FGFR4	26	6.77e-04	-0.385000	2.20e-03
Postmitotic nuclear pore complex (NPC) reformation	26	6.80e-04	-0.385000	2.21e-03
Purine ribonucleoside monophosphate biosynthesis	11	2.72e-02	-0.384000	4.94e-02
ALK mutants bind TKIs	12	2.12e-02	-0.384000	3.99e-02
FGFR2 mutant receptor activation	32	1.74e-04	-0.383000	7.15e-04
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	6.25e-03	-0.383000	1.43e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	6.25e-03	-0.383000	1.43e-02
DNA Damage/Telomere Stress Induced Senescence	28	4.51e-04	-0.383000	1.58e-03
RNA Polymerase III Abortive And Retractive Initiation	41	2.26e-05	-0.382000	1.36e-04
RNA Polymerase III Transcription	41	2.26e-05	-0.382000	1.36e-04
Gap junction degradation	10	3.63e-02	-0.382000	6.28e-02
Metabolism of folate and pterines	16	8.21e-03	-0.382000	1.82e-02
Negative regulation of NMDA receptor-mediated neuronal transmission	20	3.18e-03	-0.381000	8.14e-03
cGMP effects	15	1.07e-02	-0.381000	2.27e-02
TRAF3-dependent IRF activation pathway	15	1.07e-02	-0.380000	2.27e-02
mRNA Editing	10	3.75e-02	0.380000	6.46e-02
MECP2 regulates neuronal receptors and channels	17	6.72e-03	-0.380000	1.52e-02
Cytosolic iron-sulfur cluster assembly	10	3.76e-02	-0.380000	6.47e-02
Signal attenuation	10	3.79e-02	-0.379000	6.48e-02
Fatty acids	15	1.13e-02	0.378000	2.37e-02
Viral Messenger RNA Synthesis	42	2.45e-05	-0.376000	1.45e-04
CRMPs in Sema3A signaling	15	1.19e-02	-0.375000	2.46e-02
MicroRNA (miRNA) biogenesis	26	9.41e-04	-0.375000	2.91e-03
RHO GTPases activate IQGAPs	11	3.14e-02	-0.375000	5.56e-02
Degradation of beta-catenin by the destruction complex	81	5.56e-09	-0.374000	9.23e-08
Pentose phosphate pathway	12	2.50e-02	-0.374000	4.62e-02
mRNA decay by 5’ to 3’ exoribonuclease	15	1.22e-02	-0.374000	2.53e-02
Platelet sensitization by LDL	17	7.65e-03	-0.373000	1.71e-02
Signaling by NTRK2 (TRKB)	25	1.29e-03	-0.372000	3.86e-03
Signaling by ALK fusions and activated point mutants	51	4.54e-06	-0.371000	3.96e-05
Signaling by ALK in cancer	51	4.54e-06	-0.371000	3.96e-05
Abortive elongation of HIV-1 transcript in the absence of Tat	23	2.08e-03	-0.371000	5.75e-03
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	3.33e-02	-0.370000	5.84e-02
Formation of the beta-catenin:TCF transactivating complex	32	2.85e-04	-0.370000	1.08e-03
PI-3K cascade:FGFR3	17	8.24e-03	-0.370000	1.82e-02
Downstream signaling of activated FGFR3	24	1.76e-03	-0.369000	5.07e-03
Signaling by NOTCH1	70	1.03e-07	-0.368000	1.33e-06
Rev-mediated nuclear export of HIV RNA	33	2.59e-04	-0.367000	1.00e-03
Defective pyroptosis	11	3.49e-02	-0.367000	6.09e-02
FOXO-mediated transcription of cell death genes	15	1.38e-02	-0.367000	2.83e-02
RNA Polymerase III Transcription Initiation	36	1.40e-04	-0.367000	6.04e-04
TRAF6 mediated NF-kB activation	24	1.90e-03	-0.366000	5.40e-03
Telomere C-strand synthesis initiation	11	3.58e-02	-0.365000	6.21e-02
Nitric oxide stimulates guanylate cyclase	22	3.10e-03	-0.364000	7.98e-03
Apoptotic cleavage of cell adhesion proteins	11	3.68e-02	-0.364000	6.34e-02
Diseases of DNA repair	49	1.09e-05	-0.363000	7.66e-05
SCF(Skp2)-mediated degradation of p27/p21	58	1.73e-06	-0.363000	1.72e-05
RND3 GTPase cycle	41	5.86e-05	-0.362000	2.98e-04
Export of Viral Ribonucleoproteins from Nucleus	31	4.84e-04	-0.362000	1.68e-03
Initial triggering of complement	21	4.10e-03	0.362000	1.00e-02
Downstream signal transduction	29	7.48e-04	-0.362000	2.39e-03
Condensation of Prometaphase Chromosomes	11	3.79e-02	-0.361000	6.48e-02
ZBP1(DAI) mediated induction of type I IFNs	20	5.21e-03	-0.361000	1.22e-02
Digestion of dietary carbohydrate	10	4.85e-02	0.360000	7.98e-02
tRNA processing in the nucleus	55	3.83e-06	-0.360000	3.44e-05
Formation of HIV elongation complex in the absence of HIV Tat	40	8.22e-05	-0.360000	3.89e-04
Translesion synthesis by POLI	17	1.03e-02	-0.359000	2.19e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	4.92e-02	-0.359000	8.07e-02
Cell-extracellular matrix interactions	14	2.00e-02	-0.359000	3.81e-02
Signaling by NTRK1 (TRKA)	114	3.46e-11	-0.359000	8.38e-10
Defective Intrinsic Pathway for Apoptosis	25	1.91e-03	-0.358000	5.42e-03
Defects in cobalamin (B12) metabolism	12	3.17e-02	-0.358000	5.59e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	5.42e-06	-0.358000	4.50e-05
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	5.42e-06	-0.358000	4.50e-05
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	5.42e-06	-0.358000	4.50e-05
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	5.42e-06	-0.358000	4.50e-05
Signaling by NOTCH1 in Cancer	54	5.42e-06	-0.358000	4.50e-05
Signaling by NOTCH4	79	4.00e-08	-0.357000	5.83e-07
Transport of Ribonucleoproteins into the Host Nucleus	30	7.66e-04	-0.355000	2.43e-03
NEP/NS2 Interacts with the Cellular Export Machinery	30	7.90e-04	-0.354000	2.49e-03
Transport of the SLBP Dependant Mature mRNA	34	3.63e-04	-0.353000	1.33e-03
Activation of the AP-1 family of transcription factors	10	5.31e-02	-0.353000	8.53e-02
Defects in vitamin and cofactor metabolism	20	6.26e-03	-0.353000	1.43e-02
Norepinephrine Neurotransmitter Release Cycle	16	1.45e-02	-0.353000	2.94e-02
MAPK targets/ Nuclear events mediated by MAP kinases	29	1.01e-03	-0.353000	3.10e-03
HIV Transcription Initiation	43	6.27e-05	-0.353000	3.10e-04
RNA Polymerase II HIV Promoter Escape	43	6.27e-05	-0.353000	3.10e-04
RNA Polymerase II Promoter Escape	43	6.27e-05	-0.353000	3.10e-04
RNA Polymerase II Transcription Initiation	43	6.27e-05	-0.353000	3.10e-04
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	6.27e-05	-0.353000	3.10e-04
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	6.27e-05	-0.353000	3.10e-04
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	1.37e-05	-0.352000	9.19e-05
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	4.34e-02	-0.352000	7.29e-02
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27	1.60e-03	-0.351000	4.67e-03
Heme biosynthesis	13	2.87e-02	-0.350000	5.15e-02
Mitotic Prometaphase	175	1.32e-15	-0.350000	5.47e-14
Translation	263	1.38e-22	-0.350000	8.81e-21
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	1.94e-02	-0.349000	3.73e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	1.94e-02	-0.349000	3.73e-02
RND2 GTPase cycle	42	9.34e-05	-0.348000	4.31e-04
Formation of the Early Elongation Complex	32	6.49e-04	-0.348000	2.12e-03
Formation of the HIV-1 Early Elongation Complex	32	6.49e-04	-0.348000	2.12e-03
Interleukin-6 signaling	11	4.55e-02	-0.348000	7.59e-02
Metabolism of cofactors	19	8.63e-03	-0.348000	1.89e-02
Transcriptional regulation by RUNX2	116	1.01e-10	-0.347000	2.06e-09
HIV elongation arrest and recovery	29	1.22e-03	-0.347000	3.71e-03
Pausing and recovery of HIV elongation	29	1.22e-03	-0.347000	3.71e-03
VxPx cargo-targeting to cilium	20	7.30e-03	-0.346000	1.64e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat	38	2.19e-04	-0.346000	8.61e-04
HIV Transcription Elongation	38	2.19e-04	-0.346000	8.61e-04
Tat-mediated elongation of the HIV-1 transcript	38	2.19e-04	-0.346000	8.61e-04
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	4.92e-03	-0.346000	1.16e-02
Transcriptional regulation by small RNAs	46	4.82e-05	-0.346000	2.51e-04
HDR through Single Strand Annealing (SSA)	36	3.24e-04	-0.346000	1.21e-03
Interactions of Rev with host cellular proteins	35	3.98e-04	-0.346000	1.43e-03
Signaling by Activin	15	2.06e-02	-0.345000	3.90e-02
Negative regulation of NOTCH4 signaling	52	1.68e-05	-0.345000	1.08e-04
EPHB-mediated forward signaling	34	5.08e-04	-0.344000	1.75e-03
Activation of AMPK downstream of NMDARs	10	5.93e-02	-0.344000	9.40e-02
Translesion synthesis by REV1	16	1.72e-02	-0.344000	3.37e-02
Cyclin E associated events during G1/S transition	81	8.66e-08	-0.344000	1.16e-06
CaMK IV-mediated phosphorylation of CREB	10	5.99e-02	-0.344000	9.44e-02
Mitotic Spindle Checkpoint	106	9.64e-10	-0.343000	1.78e-08
Cyclin A:Cdk2-associated events at S phase entry	83	6.43e-08	-0.343000	8.77e-07
Downstream signaling of activated FGFR2	29	1.38e-03	-0.343000	4.13e-03
G0 and Early G1	27	2.04e-03	-0.343000	5.65e-03
RNA polymerase II transcribes snRNA genes	77	2.05e-07	-0.342000	2.45e-06
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	1.76e-03	-0.341000	5.07e-03
Regulation of IFNG signaling	14	2.71e-02	-0.341000	4.93e-02
TP53 Regulates Transcription of DNA Repair Genes	57	8.77e-06	-0.340000	6.53e-05
Asymmetric localization of PCP proteins	62	3.56e-06	-0.340000	3.22e-05
Signaling by FGFR4 in disease	11	5.09e-02	-0.340000	8.29e-02
Activation of RAC1	11	5.09e-02	-0.340000	8.29e-02
Creation of C4 and C2 activators	14	2.79e-02	0.339000	5.03e-02
Deposition of new CENPA-containing nucleosomes at the centromere	26	2.76e-03	-0.339000	7.25e-03
Nucleosome assembly	26	2.76e-03	-0.339000	7.25e-03
Mitochondrial protein import	54	1.64e-05	-0.339000	1.07e-04
Transport of the SLBP independent Mature mRNA	33	7.55e-04	-0.339000	2.40e-03
Transcription of the HIV genome	62	3.96e-06	-0.339000	3.54e-05
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37	3.71e-04	-0.338000	1.35e-03
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	3.53e-05	-0.338000	1.96e-04
Presynaptic nicotinic acetylcholine receptors	12	4.28e-02	0.338000	7.21e-02
Signaling by FGFR3 in disease	21	7.51e-03	-0.337000	1.68e-02
Formation of RNA Pol II elongation complex	53	2.20e-05	-0.337000	1.34e-04
RNA Polymerase II Transcription Elongation	53	2.20e-05	-0.337000	1.34e-04
Impaired BRCA2 binding to RAD51	33	8.16e-04	-0.337000	2.57e-03
Estrogen-dependent gene expression	91	2.87e-08	-0.336000	4.30e-07
Separation of Sister Chromatids	161	1.68e-13	-0.336000	5.35e-12
Phospholipase C-mediated cascade; FGFR4	14	2.94e-02	-0.336000	5.26e-02
TNFR1-induced proapoptotic signaling	13	3.58e-02	-0.336000	6.21e-02
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	44	1.15e-04	-0.336000	5.11e-04
Transcriptional Regulation by MECP2	60	6.72e-06	-0.336000	5.15e-05
PI-3K cascade:FGFR2	22	6.40e-03	-0.336000	1.45e-02
TCF dependent signaling in response to WNT	168	5.59e-14	-0.336000	1.86e-12
Polo-like kinase mediated events	16	2.01e-02	-0.336000	3.82e-02
Erythrocytes take up carbon dioxide and release oxygen	12	4.42e-02	-0.335000	7.39e-02
O2/CO2 exchange in erythrocytes	12	4.42e-02	-0.335000	7.39e-02
Signaling by NTRKs	133	2.34e-11	-0.335000	5.77e-10
G1/S Transition	126	8.55e-11	-0.334000	1.81e-09
NOTCH1 Intracellular Domain Regulates Transcription	44	1.23e-04	-0.334000	5.45e-04
Transcriptional regulation of pluripotent stem cells	30	1.53e-03	-0.334000	4.51e-03
Downregulation of SMAD2/3:SMAD4 transcriptional activity	26	3.21e-03	-0.334000	8.20e-03
Ca2+ pathway	62	5.46e-06	-0.334000	4.51e-05
MET activates RAP1 and RAC1	11	5.54e-02	-0.333000	8.86e-02
Activation of ATR in response to replication stress	37	4.55e-04	-0.333000	1.59e-03
NRIF signals cell death from the nucleus	16	2.11e-02	-0.333000	3.99e-02
Phase 0 - rapid depolarisation	31	1.47e-03	-0.330000	4.34e-03
Signaling by Hippo	19	1.29e-02	-0.330000	2.65e-02
RIP-mediated NFkB activation via ZBP1	16	2.25e-02	-0.329000	4.20e-02
Mitochondrial translation	93	4.20e-08	-0.329000	6.05e-07
Regulation of TP53 Activity through Association with Co-factors	14	3.34e-02	-0.328000	5.86e-02
LDL clearance	19	1.33e-02	-0.328000	2.73e-02
Mitochondrial translation initiation	87	1.21e-07	-0.328000	1.51e-06
Unblocking of NMDA receptors, glutamate binding and activation	19	1.33e-02	-0.328000	2.73e-02
Pausing and recovery of Tat-mediated HIV elongation	27	3.25e-03	-0.327000	8.24e-03
Tat-mediated HIV elongation arrest and recovery	27	3.25e-03	-0.327000	8.24e-03
XBP1(S) activates chaperone genes	48	9.28e-05	-0.326000	4.31e-04
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	2.00e-03	-0.326000	5.64e-03
Retrograde neurotrophin signalling	14	3.48e-02	-0.326000	6.07e-02
NOTCH4 Intracellular Domain Regulates Transcription	19	1.39e-02	-0.326000	2.84e-02
RNA Polymerase II Pre-transcription Events	73	1.49e-06	-0.326000	1.52e-05
Dual incision in TC-NER	63	7.85e-06	-0.325000	5.91e-05
RHOC GTPase cycle	69	2.97e-06	-0.325000	2.74e-05
Defective B4GALT7 causes EDS, progeroid type	17	2.03e-02	-0.325000	3.86e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	4.26e-02	-0.325000	7.19e-02
Mitotic G1 phase and G1/S transition	144	1.70e-11	-0.324000	4.34e-10
Mitochondrial translation termination	87	1.66e-07	-0.324000	2.02e-06
Degradation of AXIN	53	4.48e-05	-0.324000	2.36e-04
Activation of SMO	17	2.09e-02	-0.324000	3.94e-02
Incretin synthesis, secretion, and inactivation	23	7.25e-03	-0.323000	1.63e-02
VEGFR2 mediated vascular permeability	26	4.36e-03	-0.323000	1.06e-02
Retrograde transport at the Trans-Golgi-Network	47	1.28e-04	-0.323000	5.64e-04
Anchoring of the basal body to the plasma membrane	92	8.92e-08	-0.322000	1.18e-06
HCMV Early Events	55	3.54e-05	-0.322000	1.96e-04
Telomere C-strand (Lagging Strand) Synthesis	32	1.62e-03	-0.322000	4.73e-03
Activated NOTCH1 Transmits Signal to the Nucleus	31	1.94e-03	-0.322000	5.46e-03
Hedgehog ligand biogenesis	63	1.02e-05	-0.321000	7.30e-05
Regulation of PTEN stability and activity	66	6.34e-06	-0.321000	4.95e-05
Cell Cycle Checkpoints	248	2.86e-18	-0.321000	1.41e-16
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	5.24e-04	-0.321000	1.79e-03
Diseases of DNA Double-Strand Break Repair	39	5.24e-04	-0.321000	1.79e-03
Mitochondrial iron-sulfur cluster biogenesis	12	5.43e-02	-0.321000	8.71e-02
G1/S-Specific Transcription	28	3.31e-03	-0.321000	8.35e-03
FRS-mediated FGFR4 signaling	21	1.10e-02	-0.320000	2.32e-02
Diseases of programmed cell death	41	3.84e-04	-0.320000	1.39e-03
Presynaptic phase of homologous DNA pairing and strand exchange	38	6.39e-04	-0.320000	2.10e-03
Mitotic Telophase/Cytokinesis	10	7.97e-02	-0.320000	1.19e-01
Degradation of cysteine and homocysteine	14	3.82e-02	-0.320000	6.52e-02
Metabolism of polyamines	55	4.10e-05	-0.320000	2.20e-04
RUNX1 regulates transcription of genes involved in differentiation of HSCs	68	5.11e-06	-0.320000	4.39e-05
Cargo trafficking to the periciliary membrane	49	1.08e-04	-0.320000	4.89e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	9.22e-05	-0.319000	4.30e-04
p53-Independent DNA Damage Response	50	9.22e-05	-0.319000	4.30e-04
p53-Independent G1/S DNA damage checkpoint	50	9.22e-05	-0.319000	4.30e-04
SUMOylation of DNA replication proteins	44	2.49e-04	-0.319000	9.62e-04
Diseases of signal transduction by growth factor receptors and second messengers	410	1.43e-28	-0.318000	1.29e-26
Regulation of RAS by GAPs	66	7.69e-06	-0.318000	5.82e-05
Transcriptional regulation by RUNX3	93	1.12e-07	-0.318000	1.42e-06
RORA activates gene expression	17	2.33e-02	-0.318000	4.33e-02
Chromosome Maintenance	86	3.48e-07	-0.318000	3.91e-06
Host Interactions of HIV factors	122	1.33e-09	-0.317000	2.43e-08
Interleukin-35 Signalling	12	5.72e-02	-0.317000	9.09e-02
Cap-dependent Translation Initiation	112	6.67e-09	-0.317000	1.07e-07
Eukaryotic Translation Initiation	112	6.67e-09	-0.317000	1.07e-07
Signaling by WNT	263	9.47e-19	-0.316000	4.99e-17
Beta-catenin independent WNT signaling	144	5.70e-11	-0.316000	1.28e-09
EPH-Ephrin signaling	90	2.23e-07	-0.316000	2.62e-06
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	20	1.45e-02	-0.316000	2.94e-02
Ubiquitin-dependent degradation of Cyclin D	50	1.12e-04	-0.316000	5.02e-04
Loss of Nlp from mitotic centrosomes	65	1.07e-05	-0.316000	7.57e-05
Loss of proteins required for interphase microtubule organization from the centrosome	65	1.07e-05	-0.316000	7.57e-05
Activation of NMDA receptors and postsynaptic events	69	5.99e-06	-0.315000	4.77e-05
Transcriptional regulation of white adipocyte differentiation	81	9.66e-07	-0.315000	1.01e-05
HS-GAG degradation	18	2.08e-02	-0.315000	3.94e-02
PCP/CE pathway	90	2.46e-07	-0.314000	2.83e-06
Golgi Associated Vesicle Biogenesis	51	1.01e-04	-0.314000	4.62e-04
VEGFR2 mediated cell proliferation	19	1.76e-02	-0.314000	3.43e-02
Mitochondrial translation elongation	87	3.95e-07	-0.314000	4.34e-06
HIV Life Cycle	139	1.54e-10	-0.314000	3.05e-09
Nuclear Pore Complex (NPC) Disassembly	34	1.53e-03	-0.314000	4.51e-03
GLI3 is processed to GLI3R by the proteasome	58	3.55e-05	-0.314000	1.97e-04
DAG and IP3 signaling	39	7.00e-04	-0.314000	2.25e-03
Defective B3GAT3 causes JDSSDHD	17	2.52e-02	-0.313000	4.64e-02
Metabolism of nitric oxide: NOS3 activation and regulation	15	3.55e-02	-0.313000	6.17e-02
Regulation of RUNX2 expression and activity	71	4.87e-06	-0.313000	4.23e-05
Signaling by FGFR in disease	61	2.29e-05	-0.313000	1.37e-04
Regulation of ornithine decarboxylase (ODC)	49	1.48e-04	-0.313000	6.24e-04
DNA Damage Bypass	46	2.42e-04	-0.313000	9.43e-04
Keratinization	214	3.10e-15	0.312000	1.25e-13
TNFR1-induced NFkappaB signaling pathway	22	1.12e-02	-0.312000	2.37e-02
SUMOylation of SUMOylation proteins	33	1.91e-03	-0.312000	5.42e-03
Cilium Assembly	174	1.17e-12	-0.312000	3.38e-11
B-WICH complex positively regulates rRNA expression	29	3.63e-03	-0.312000	8.99e-03
MAPK3 (ERK1) activation	10	8.75e-02	-0.312000	1.29e-01
tRNA processing	98	9.44e-08	-0.312000	1.23e-06
Intraflagellar transport	36	1.23e-03	-0.311000	3.73e-03
Translocation of ZAP-70 to Immunological synapse	17	2.65e-02	0.311000	4.83e-02
Homologous DNA Pairing and Strand Exchange	41	5.73e-04	-0.311000	1.93e-03
Activated NTRK2 signals through FRS2 and FRS3	11	7.43e-02	-0.311000	1.13e-01
SUMOylation of transcription factors	20	1.63e-02	-0.310000	3.24e-02
Hh mutants abrogate ligand secretion	57	5.10e-05	-0.310000	2.63e-04
Regulation of expression of SLITs and ROBOs	159	1.48e-11	-0.310000	3.83e-10
RHO GTPases activate CIT	19	1.94e-02	-0.310000	3.73e-02
G2/M DNA damage checkpoint	58	4.44e-05	-0.310000	2.35e-04
Regulation of Apoptosis	51	1.29e-04	-0.310000	5.64e-04
Metabolism of Angiotensinogen to Angiotensins	15	3.78e-02	0.310000	6.48e-02
Telomere Maintenance	62	2.45e-05	-0.310000	1.45e-04
SHC-mediated cascade:FGFR4	19	1.94e-02	-0.310000	3.73e-02
Constitutive Signaling by AKT1 E17K in Cancer	25	7.47e-03	-0.309000	1.68e-02
Regulation of pyruvate dehydrogenase (PDH) complex	14	4.53e-02	-0.309000	7.57e-02
Recognition of DNA damage by PCNA-containing replication complex	29	3.98e-03	-0.309000	9.78e-03
Dermatan sulfate biosynthesis	10	9.08e-02	-0.309000	1.33e-01
Nervous system development	527	4.56e-34	-0.309000	6.97e-32
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	3.42e-03	-0.309000	8.50e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	3.42e-03	-0.309000	8.50e-03
Activation of BH3-only proteins	30	3.49e-03	-0.308000	8.65e-03
CLEC7A (Dectin-1) induces NFAT activation	11	7.70e-02	-0.308000	1.16e-01
Purine salvage	12	6.52e-02	-0.307000	1.01e-01
Negative epigenetic regulation of rRNA expression	45	3.59e-04	-0.307000	1.32e-03
SRP-dependent cotranslational protein targeting to membrane	105	5.27e-08	-0.307000	7.25e-07
Signaling by ROBO receptors	203	4.27e-14	-0.307000	1.52e-12
Base Excision Repair	45	3.66e-04	-0.307000	1.34e-03
FGFR2c ligand binding and activation	12	6.58e-02	-0.307000	1.02e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	62	3.00e-05	-0.306000	1.74e-04
Organelle biogenesis and maintenance	243	1.79e-16	-0.306000	7.80e-15
SARS-CoV-2 modulates autophagy	11	7.89e-02	-0.306000	1.18e-01
HIV Infection	216	8.68e-15	-0.306000	3.40e-13
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	6.66e-02	-0.306000	1.03e-01
RHOV GTPase cycle	36	1.50e-03	-0.306000	4.44e-03
RNA Polymerase I Promoter Escape	28	5.11e-03	-0.306000	1.20e-02
FGFR4 ligand binding and activation	13	5.64e-02	-0.305000	8.99e-02
RNA Polymerase II Transcription Termination	62	3.18e-05	-0.305000	1.82e-04
Syndecan interactions	19	2.12e-02	-0.305000	3.99e-02
Axon guidance	503	6.18e-32	-0.305000	7.86e-30
IRE1alpha activates chaperones	50	1.88e-04	-0.305000	7.68e-04
Biotin transport and metabolism	10	9.48e-02	-0.305000	1.38e-01
Mitochondrial Fatty Acid Beta-Oxidation	35	1.79e-03	-0.305000	5.14e-03
Transcriptional regulation of granulopoiesis	31	3.29e-03	-0.305000	8.33e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	108	4.33e-08	-0.305000	6.12e-07
Nonsense-Mediated Decay (NMD)	108	4.33e-08	-0.305000	6.12e-07
Response of EIF2AK1 (HRI) to heme deficiency	14	4.83e-02	-0.305000	7.95e-02
Ub-specific processing proteases	157	4.21e-11	-0.305000	1.00e-09
Ephrin signaling	17	2.96e-02	-0.305000	5.28e-02
FGFRL1 modulation of FGFR1 signaling	13	5.71e-02	-0.305000	9.09e-02
G1/S DNA Damage Checkpoints	66	1.85e-05	-0.305000	1.17e-04
Neurotransmitter release cycle	47	3.04e-04	-0.304000	1.14e-03
Deactivation of the beta-catenin transactivating complex	39	9.99e-04	-0.304000	3.08e-03
BBSome-mediated cargo-targeting to cilium	23	1.16e-02	-0.304000	2.42e-02
Neurexins and neuroligins	52	1.48e-04	-0.304000	6.24e-04
Regulation of beta-cell development	41	7.51e-04	-0.304000	2.40e-03
Late Phase of HIV Life Cycle	126	3.67e-09	-0.304000	6.16e-08
Influenza Viral RNA Transcription and Replication	129	2.45e-09	-0.304000	4.31e-08
trans-Golgi Network Vesicle Budding	67	1.72e-05	-0.304000	1.10e-04
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	11	8.17e-02	0.303000	1.22e-01
Assembly and cell surface presentation of NMDA receptors	23	1.18e-02	-0.303000	2.46e-02
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	2.24e-02	-0.302000	4.19e-02
Vpu mediated degradation of CD4	50	2.14e-04	-0.302000	8.52e-04
DNA Double-Strand Break Repair	130	2.51e-09	-0.302000	4.36e-08
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	6.83e-06	-0.302000	5.19e-05
Antigen processing: Ubiquitination & Proteasome degradation	293	4.77e-19	-0.302000	2.60e-17
Nuclear import of Rev protein	32	3.12e-03	-0.302000	8.02e-03
Regulation of gene expression in beta cells	21	1.66e-02	-0.302000	3.29e-02
Influenza Infection	148	2.24e-10	-0.302000	4.33e-09
COPI-mediated anterograde transport	83	1.98e-06	-0.302000	1.92e-05
Regulation of RUNX3 expression and activity	53	1.44e-04	-0.302000	6.14e-04
Protein-protein interactions at synapses	78	4.05e-06	-0.302000	3.59e-05
Hh mutants are degraded by ERAD	54	1.29e-04	-0.301000	5.64e-04
Transport of Mature Transcript to Cytoplasm	76	5.62e-06	-0.301000	4.62e-05
G2/M Checkpoints	129	3.67e-09	-0.300000	6.16e-08
p53-Dependent G1 DNA Damage Response	64	3.30e-05	-0.300000	1.86e-04
p53-Dependent G1/S DNA damage checkpoint	64	3.30e-05	-0.300000	1.86e-04
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	3.25e-02	-0.299000	5.72e-02
Signaling by TGF-beta Receptor Complex	86	1.56e-06	-0.299000	1.59e-05
ESR-mediated signaling	160	6.08e-11	-0.299000	1.31e-09
Signaling by PDGF	52	1.87e-04	-0.299000	7.66e-04
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	3.38e-03	-0.299000	8.47e-03
SUMOylation of RNA binding proteins	45	5.13e-04	-0.299000	1.76e-03
PI-3K cascade:FGFR1	21	1.76e-02	-0.299000	3.43e-02
Regulation of FZD by ubiquitination	21	1.77e-02	-0.299000	3.44e-02
Energy dependent regulation of mTOR by LKB1-AMPK	28	6.24e-03	-0.298000	1.43e-02
Sensory processing of sound by inner hair cells of the cochlea	62	4.84e-05	-0.298000	2.51e-04
Processing of DNA double-strand break ends	61	5.59e-05	-0.298000	2.86e-04
AURKA Activation by TPX2	68	2.11e-05	-0.298000	1.31e-04
Vif-mediated degradation of APOBEC3G	50	2.66e-04	-0.298000	1.02e-03
DNA Repair	277	1.67e-17	-0.297000	7.99e-16
GABA synthesis, release, reuptake and degradation	19	2.51e-02	-0.297000	4.63e-02
Interaction With Cumulus Cells And The Zona Pellucida	11	8.86e-02	0.296000	1.30e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	6.47e-02	-0.296000	1.01e-01
Signaling by NOTCH2	32	3.77e-03	-0.296000	9.30e-03
Phospholipase C-mediated cascade; FGFR3	12	7.60e-02	-0.296000	1.15e-01
FOXO-mediated transcription	65	3.81e-05	-0.295000	2.08e-04
Reactions specific to the complex N-glycan synthesis pathway	10	1.06e-01	-0.295000	1.52e-01
PRC2 methylates histones and DNA	13	6.55e-02	-0.295000	1.02e-01
Protein ubiquitination	61	6.76e-05	-0.295000	3.29e-04
HATs acetylate histones	71	1.74e-05	-0.295000	1.11e-04
TP53 Regulates Transcription of Cell Cycle Genes	49	3.57e-04	-0.295000	1.31e-03
Neddylation	228	1.73e-14	-0.294000	6.63e-13
MyD88 cascade initiated on plasma membrane	79	6.06e-06	-0.294000	4.77e-05
Toll Like Receptor 10 (TLR10) Cascade	79	6.06e-06	-0.294000	4.77e-05
Toll Like Receptor 5 (TLR5) Cascade	79	6.06e-06	-0.294000	4.77e-05
Long-term potentiation	22	1.69e-02	-0.294000	3.33e-02
Degradation of GLI1 by the proteasome	58	1.07e-04	-0.294000	4.87e-04
SCF-beta-TrCP mediated degradation of Emi1	53	2.16e-04	-0.294000	8.57e-04
FRS-mediated FGFR3 signaling	19	2.68e-02	-0.293000	4.88e-02
Formation of the cornified envelope	74	1.29e-05	0.293000	8.78e-05
GTP hydrolysis and joining of the 60S ribosomal subunit	105	2.09e-07	-0.293000	2.48e-06
Sensory processing of sound by outer hair cells of the cochlea	49	3.87e-04	-0.293000	1.40e-03
Defective CFTR causes cystic fibrosis	59	9.90e-05	-0.293000	4.54e-04
Receptor-type tyrosine-protein phosphatases	16	4.27e-02	-0.293000	7.20e-02
SUMOylation of chromatin organization proteins	54	2.01e-04	-0.292000	8.09e-04
RHOF GTPase cycle	40	1.39e-03	-0.292000	4.13e-03
Formation of the ternary complex, and subsequently, the 43S complex	47	5.43e-04	-0.291000	1.85e-03
Gap-filling DNA repair synthesis and ligation in TC-NER	62	7.30e-05	-0.291000	3.51e-04
Formation of a pool of free 40S subunits	95	9.61e-07	-0.291000	1.01e-05
Acetylcholine binding and downstream events	14	5.98e-02	0.290000	9.43e-02
Postsynaptic nicotinic acetylcholine receptors	14	5.98e-02	0.290000	9.43e-02
NS1 Mediated Effects on Host Pathways	39	1.68e-03	-0.290000	4.90e-03
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	8.17e-02	-0.290000	1.22e-01
Eukaryotic Translation Elongation	88	2.50e-06	-0.290000	2.34e-05
TBC/RABGAPs	42	1.14e-03	-0.290000	3.48e-03
ISG15 antiviral mechanism	71	2.38e-05	-0.290000	1.41e-04
RHO GTPase Effectors	232	3.03e-14	-0.289000	1.10e-12
Degradation of GLI2 by the proteasome	58	1.41e-04	-0.289000	6.06e-04
STAT5 activation downstream of FLT3 ITD mutants	10	1.14e-01	-0.289000	1.60e-01
Ethanol oxidation	12	8.32e-02	0.289000	1.23e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	2.45e-04	-0.288000	9.52e-04
Toll Like Receptor 3 (TLR3) Cascade	88	2.90e-06	-0.288000	2.69e-05
Negative regulation of MAPK pathway	41	1.40e-03	-0.288000	4.17e-03
Elevation of cytosolic Ca2+ levels	16	4.60e-02	-0.288000	7.66e-02
Signaling by KIT in disease	20	2.57e-02	-0.288000	4.71e-02
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	2.57e-02	-0.288000	4.71e-02
Orc1 removal from chromatin	69	3.52e-05	-0.288000	1.96e-04
DCC mediated attractive signaling	14	6.22e-02	-0.288000	9.74e-02
Signaling by BMP	27	9.62e-03	-0.288000	2.07e-02
Chromatin modifying enzymes	185	1.41e-11	-0.288000	3.72e-10
Chromatin organization	185	1.41e-11	-0.288000	3.72e-10
Mitochondrial biogenesis	69	3.56e-05	-0.288000	1.97e-04
Metabolism of non-coding RNA	50	4.41e-04	-0.287000	1.55e-03
snRNP Assembly	50	4.41e-04	-0.287000	1.55e-03
Phosphorylation of CD3 and TCR zeta chains	20	2.62e-02	0.287000	4.78e-02
RAF activation	33	4.30e-03	-0.287000	1.05e-02
Resolution of Abasic Sites (AP sites)	37	2.52e-03	-0.287000	6.67e-03
Nuclear events mediated by NFE2L2	76	1.53e-05	-0.287000	1.01e-04
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.53e-05	-0.287000	1.01e-04
Regulation of PLK1 Activity at G2/M Transition	83	6.34e-06	-0.286000	4.95e-05
Mitotic Metaphase and Anaphase	222	1.81e-13	-0.286000	5.66e-12
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	5.99e-04	-0.286000	1.98e-03
Formation of TC-NER Pre-Incision Complex	51	4.08e-04	-0.286000	1.46e-03
Post NMDA receptor activation events	58	1.64e-04	-0.286000	6.83e-04
Recruitment of NuMA to mitotic centrosomes	76	1.62e-05	-0.286000	1.06e-04
Signaling by FGFR2	72	2.78e-05	-0.285000	1.63e-04
Cellular response to hypoxia	71	3.25e-05	-0.285000	1.85e-04
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	94	1.77e-06	-0.285000	1.75e-05
Cytosolic sensors of pathogen-associated DNA	60	1.35e-04	-0.285000	5.88e-04
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	55	2.60e-04	-0.285000	1.00e-03
Antiviral mechanism by IFN-stimulated genes	78	1.41e-05	-0.284000	9.42e-05
E3 ubiquitin ligases ubiquitinate target proteins	43	1.26e-03	-0.284000	3.79e-03
PCNA-Dependent Long Patch Base Excision Repair	21	2.42e-02	-0.284000	4.48e-02
NoRC negatively regulates rRNA expression	43	1.27e-03	-0.284000	3.81e-03
Platelet homeostasis	85	5.94e-06	-0.284000	4.77e-05
Citric acid cycle (TCA cycle)	21	2.42e-02	-0.284000	4.49e-02
MyD88 dependent cascade initiated on endosome	84	6.74e-06	-0.284000	5.15e-05
Toll Like Receptor 7/8 (TLR7/8) Cascade	84	6.74e-06	-0.284000	5.15e-05
NCAM1 interactions	36	3.19e-03	-0.284000	8.15e-03
CD28 dependent PI3K/Akt signaling	22	2.12e-02	-0.284000	3.99e-02
RHOU GTPase cycle	37	2.80e-03	-0.284000	7.33e-03
Mitotic Anaphase	221	3.33e-13	-0.284000	1.01e-11
CaM pathway	33	4.84e-03	-0.283000	1.14e-02
Calmodulin induced events	33	4.84e-03	-0.283000	1.14e-02
Branched-chain amino acid catabolism	20	2.87e-02	-0.282000	5.15e-02
L13a-mediated translational silencing of Ceruloplasmin expression	104	6.39e-07	-0.282000	6.97e-06
Voltage gated Potassium channels	42	1.55e-03	-0.282000	4.54e-03
FCERI mediated NF-kB activation	74	2.72e-05	-0.282000	1.60e-04
Heparan sulfate/heparin (HS-GAG) metabolism	49	6.40e-04	-0.282000	2.10e-03
Regulation of MECP2 expression and activity	30	7.54e-03	-0.282000	1.69e-02
Interleukin-15 signaling	13	7.86e-02	-0.282000	1.18e-01
Signaling by TGFB family members	114	2.01e-07	-0.282000	2.42e-06
Ribosomal scanning and start codon recognition	54	3.44e-04	-0.281000	1.27e-03
HDACs deacetylate histones	29	8.73e-03	-0.281000	1.91e-02
Glutamate Neurotransmitter Release Cycle	23	1.96e-02	-0.281000	3.75e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	38	2.71e-03	-0.281000	7.14e-03
Synthesis of substrates in N-glycan biosythesis	60	1.66e-04	-0.281000	6.87e-04
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	83	9.52e-06	-0.281000	7.00e-05
mRNA 3’-end processing	53	4.01e-04	-0.281000	1.44e-03
Protein methylation	16	5.17e-02	-0.281000	8.37e-02
Glucuronidation	25	1.50e-02	0.281000	3.02e-02
Regulation of signaling by CBL	18	3.91e-02	-0.281000	6.64e-02
Autodegradation of the E3 ubiquitin ligase COP1	50	5.93e-04	-0.281000	1.97e-03
MyD88-independent TLR4 cascade	92	3.29e-06	-0.280000	3.00e-05
TRIF(TICAM1)-mediated TLR4 signaling	92	3.29e-06	-0.280000	3.00e-05
Centrosome maturation	77	2.14e-05	-0.280000	1.32e-04
Recruitment of mitotic centrosome proteins and complexes	77	2.14e-05	-0.280000	1.32e-04
Signaling by FLT3 ITD and TKD mutants	16	5.25e-02	-0.280000	8.46e-02
p75NTR signals via NF-kB	15	6.05e-02	-0.280000	9.53e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	34	4.76e-03	-0.280000	1.13e-02
Interleukin-1 signaling	97	1.92e-06	-0.280000	1.87e-05
Ketone body metabolism	10	1.26e-01	-0.279000	1.73e-01
Extension of Telomeres	48	8.18e-04	-0.279000	2.57e-03
G2/M Transition	176	1.64e-10	-0.279000	3.21e-09
TNF signaling	40	2.27e-03	-0.279000	6.13e-03
Extra-nuclear estrogen signaling	73	3.76e-05	-0.279000	2.06e-04
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	2.64e-06	-0.279000	2.46e-05
Nuclear Envelope Breakdown	50	6.50e-04	-0.279000	2.12e-03
Mitotic G2-G2/M phases	178	1.42e-10	-0.278000	2.86e-09
Signaling by FGFR1 in disease	37	3.38e-03	-0.278000	8.47e-03
SHC-mediated cascade:FGFR3	17	4.71e-02	-0.278000	7.80e-02
p75 NTR receptor-mediated signalling	89	5.74e-06	-0.278000	4.69e-05
FRS-mediated FGFR2 signaling	24	1.84e-02	-0.278000	3.56e-02
Hedgehog ‘off’ state	97	2.23e-06	-0.278000	2.12e-05
Regulation of KIT signaling	16	5.45e-02	-0.278000	8.72e-02
Deubiquitination	230	3.75e-13	-0.278000	1.10e-11
Sensory processing of sound	69	6.66e-05	-0.277000	3.27e-04
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	42	1.87e-03	-0.277000	5.34e-03
Mitotic Prophase	78	2.29e-05	-0.277000	1.37e-04
Translesion synthesis by POLK	17	4.80e-02	-0.277000	7.92e-02
M Phase	336	2.58e-18	-0.276000	1.31e-16
Rap1 signalling	16	5.56e-02	-0.276000	8.87e-02
Glutamate and glutamine metabolism	12	9.73e-02	-0.276000	1.40e-01
Cell Cycle, Mitotic	477	3.53e-25	-0.276000	2.84e-23
CTLA4 inhibitory signaling	21	2.84e-02	-0.276000	5.12e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	5.14e-04	-0.276000	1.76e-03
Synthesis of IP3 and IP4 in the cytosol	25	1.70e-02	-0.276000	3.35e-02
mRNA Splicing - Major Pathway	173	3.83e-10	-0.276000	7.31e-09
The role of GTSE1 in G2/M progression after G2 checkpoint	58	2.84e-04	-0.275000	1.08e-03
Glycosphingolipid metabolism	40	2.59e-03	-0.275000	6.84e-03
Ras activation upon Ca2+ influx through NMDA receptor	19	3.78e-02	-0.275000	6.48e-02
Signaling by VEGF	101	1.77e-06	-0.275000	1.75e-05
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	3.38e-03	-0.275000	8.47e-03
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	1.75e-02	-0.274000	3.41e-02
Digestion and absorption	26	1.55e-02	0.274000	3.09e-02
APC/C:Cdc20 mediated degradation of mitotic proteins	74	4.52e-05	-0.274000	2.38e-04
Translation initiation complex formation	54	4.98e-04	-0.274000	1.72e-03
UCH proteinases	81	2.03e-05	-0.274000	1.27e-04
RHOJ GTPase cycle	51	7.16e-04	-0.274000	2.29e-03
Eukaryotic Translation Termination	87	1.02e-05	-0.274000	7.30e-05
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	4.19e-05	-0.273000	2.23e-04
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	5.76e-04	-0.273000	1.94e-03
Phospholipase C-mediated cascade; FGFR2	17	5.11e-02	-0.273000	8.30e-02
Homology Directed Repair	100	2.32e-06	-0.273000	2.19e-05
NF-kB is activated and signals survival	12	1.01e-01	-0.273000	1.46e-01
Viral mRNA Translation	84	1.52e-05	-0.273000	1.01e-04
Platelet calcium homeostasis	27	1.42e-02	-0.273000	2.88e-02
Elastic fibre formation	41	2.53e-03	-0.272000	6.68e-03
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	7.14e-05	-0.272000	3.44e-04
Opioid Signalling	88	9.86e-06	-0.272000	7.17e-05
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	8.91e-06	-0.272000	6.58e-05
Degradation of DVL	55	4.80e-04	-0.272000	1.67e-03
APC/C-mediated degradation of cell cycle proteins	86	1.28e-05	-0.272000	8.76e-05
Regulation of mitotic cell cycle	86	1.28e-05	-0.272000	8.76e-05
HDR through MMEJ (alt-NHEJ)	11	1.19e-01	-0.272000	1.66e-01
Peptide chain elongation	84	1.68e-05	-0.271000	1.09e-04
G-protein mediated events	52	7.10e-04	-0.271000	2.28e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	6.83e-05	-0.271000	3.31e-04
Netrin-1 signaling	49	1.03e-03	-0.271000	3.17e-03
Activation of NF-kappaB in B cells	64	1.79e-04	-0.271000	7.33e-04
TGF-beta receptor signaling activates SMADs	45	1.69e-03	-0.270000	4.91e-03
MyD88 deficiency (TLR2/4)	16	6.12e-02	0.270000	9.61e-02
Kinesins	42	2.45e-03	-0.270000	6.56e-03
NIK–>noncanonical NF-kB signaling	57	4.24e-04	-0.270000	1.51e-03
Nucleotide Excision Repair	107	1.40e-06	-0.270000	1.45e-05
FGFR1 mutant receptor activation	30	1.06e-02	-0.270000	2.25e-02
Activation of the TFAP2 (AP-2) family of transcription factors	11	1.22e-01	-0.270000	1.69e-01
Meiotic recombination	26	1.73e-02	-0.269000	3.39e-02
Ca-dependent events	35	5.79e-03	-0.269000	1.34e-02
Processing of Capped Intron-Containing Pre-mRNA	231	1.60e-12	-0.269000	4.44e-11
Cell Cycle	602	1.02e-29	-0.269000	1.20e-27
Signaling by ERBB2 ECD mutants	15	7.11e-02	-0.269000	1.09e-01
Complement cascade	56	4.94e-04	0.269000	1.71e-03
RHOB GTPase cycle	66	1.57e-04	-0.269000	6.57e-04
Regulation of APC/C activators between G1/S and early anaphase	79	3.60e-05	-0.269000	1.98e-04
Nonhomologous End-Joining (NHEJ)	32	8.52e-03	-0.269000	1.87e-02
S Phase	157	6.12e-09	-0.269000	1.00e-07
Downstream signaling events of B Cell Receptor (BCR)	78	4.09e-05	-0.268000	2.20e-04
Dual Incision in GG-NER	39	3.70e-03	-0.268000	9.16e-03
Termination of translesion DNA synthesis	31	9.80e-03	-0.268000	2.10e-02
MTOR signalling	40	3.39e-03	-0.268000	8.47e-03
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	8.35e-02	-0.267000	1.24e-01
Miscellaneous transport and binding events	21	3.42e-02	-0.267000	5.97e-02
RHOBTB1 GTPase cycle	22	3.08e-02	-0.266000	5.46e-02
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	1.68e-02	-0.266000	3.32e-02
Regulation of TP53 Activity through Phosphorylation	88	1.63e-05	-0.266000	1.06e-04
ER to Golgi Anterograde Transport	134	1.10e-07	-0.265000	1.41e-06
Hormone ligand-binding receptors	13	9.80e-02	-0.265000	1.41e-01
Chemokine receptors bind chemokines	56	6.04e-04	0.265000	1.99e-03
SUMO E3 ligases SUMOylate target proteins	158	8.97e-09	-0.265000	1.41e-07
SHC-mediated cascade:FGFR2	22	3.16e-02	-0.265000	5.59e-02
Hedgehog ‘on’ state	83	3.06e-05	-0.265000	1.76e-04
Digestion	21	3.58e-02	0.264000	6.21e-02
Interaction between L1 and Ankyrins	28	1.54e-02	-0.264000	3.07e-02
VEGFA-VEGFR2 Pathway	93	1.04e-05	-0.264000	7.40e-05
mRNA Splicing	183	6.71e-10	-0.264000	1.25e-08
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	604	9.57e-29	-0.264000	9.14e-27
Nucleotide biosynthesis	14	8.75e-02	-0.264000	1.29e-01
Selenocysteine synthesis	87	2.11e-05	-0.264000	1.31e-04
RNA Polymerase I Transcription Termination	27	1.78e-02	-0.263000	3.44e-02
MAPK6/MAPK4 signaling	89	1.73e-05	-0.263000	1.11e-04
COPI-dependent Golgi-to-ER retrograde traffic	81	4.15e-05	-0.263000	2.22e-04
Signaling by Leptin	11	1.31e-01	-0.263000	1.79e-01
RUNX3 regulates NOTCH signaling	13	1.01e-01	-0.263000	1.45e-01
Interleukin-10 signaling	45	2.31e-03	0.262000	6.23e-03
Asparagine N-linked glycosylation	278	4.74e-14	-0.262000	1.61e-12
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	7.91e-02	-0.262000	1.18e-01
Laminin interactions	23	3.01e-02	-0.261000	5.35e-02
Downstream signaling of activated FGFR1	31	1.19e-02	-0.261000	2.46e-02
SUMOylation of ubiquitinylation proteins	37	6.00e-03	-0.261000	1.38e-02
Activation of gene expression by SREBF (SREBP)	42	3.42e-03	-0.261000	8.50e-03
DNA Replication Pre-Initiation	97	8.85e-06	-0.261000	6.57e-05
Transcriptional activation of mitochondrial biogenesis	51	1.27e-03	-0.261000	3.81e-03
Signaling by Rho GTPases	590	1.92e-27	-0.261000	1.63e-25
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	9.14e-02	-0.260000	1.33e-01
Regulation of Complement cascade	45	2.51e-03	0.260000	6.66e-03
VLDLR internalisation and degradation	16	7.19e-02	-0.260000	1.10e-01
Synaptic adhesion-like molecules	19	4.99e-02	-0.260000	8.17e-02
Defective GALNT3 causes HFTC	18	5.66e-02	0.259000	9.01e-02
Formation of Incision Complex in GG-NER	40	4.51e-03	-0.259000	1.08e-02
Signaling by NOTCH	183	1.39e-09	-0.259000	2.50e-08
HDR through Homologous Recombination (HRR)	65	3.04e-04	-0.259000	1.14e-03
Adrenaline,noradrenaline inhibits insulin secretion	28	1.77e-02	-0.259000	3.44e-02
Intra-Golgi and retrograde Golgi-to-ER traffic	181	1.82e-09	-0.259000	3.24e-08
Death Receptor Signalling	129	3.77e-07	-0.259000	4.18e-06
Interleukin-7 signaling	21	4.01e-02	-0.259000	6.80e-02
Lagging Strand Synthesis	19	5.10e-02	-0.259000	8.29e-02
Cytoprotection by HMOX1	58	6.56e-04	-0.258000	2.14e-03
Signaling by FGFR	85	3.86e-05	-0.258000	2.10e-04
PECAM1 interactions	12	1.22e-01	-0.258000	1.69e-01
DSCAM interactions	11	1.39e-01	-0.258000	1.88e-01
Deadenylation-dependent mRNA decay	56	8.54e-04	-0.257000	2.66e-03
Metabolism of RNA	638	8.36e-29	-0.257000	8.51e-27
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	1.39e-01	-0.257000	1.88e-01
Golgi-to-ER retrograde transport	115	1.83e-06	-0.257000	1.79e-05
Cell death signalling via NRAGE, NRIF and NADE	69	2.21e-04	-0.257000	8.68e-04
Class I MHC mediated antigen processing & presentation	363	3.64e-17	-0.257000	1.68e-15
Toll Like Receptor 9 (TLR9) Cascade	88	3.12e-05	-0.257000	1.79e-04
Heme signaling	45	2.89e-03	-0.257000	7.50e-03
DNA Replication	125	7.24e-07	-0.256000	7.73e-06
Assembly of the pre-replicative complex	82	6.00e-05	-0.256000	3.04e-04
AKT phosphorylates targets in the cytosol	14	9.71e-02	-0.256000	1.40e-01
FGFR3 mutant receptor activation	11	1.42e-01	-0.256000	1.91e-01
Signaling by activated point mutants of FGFR3	11	1.42e-01	-0.256000	1.91e-01
SUMOylation of intracellular receptors	29	1.71e-02	-0.256000	3.35e-02
Regulation of TNFR1 signaling	32	1.23e-02	-0.256000	2.54e-02
SUMOylation of DNA damage response and repair proteins	71	1.93e-04	-0.256000	7.82e-04
Fc epsilon receptor (FCERI) signaling	126	7.23e-07	-0.255000	7.73e-06
Signaling by Hedgehog	133	3.59e-07	-0.255000	4.00e-06
RHOD GTPase cycle	49	2.01e-03	-0.255000	5.64e-03
Signaling by Erythropoietin	25	2.76e-02	-0.254000	5.00e-02
Oncogenic MAPK signaling	76	1.25e-04	-0.254000	5.53e-04
Prefoldin mediated transfer of substrate to CCT/TriC	27	2.22e-02	-0.254000	4.17e-02
Signaling by CSF3 (G-CSF)	28	1.99e-02	-0.254000	3.81e-02
Signalling to RAS	20	4.93e-02	-0.254000	8.08e-02
SUMOylation	164	1.97e-08	-0.254000	2.98e-07
MASTL Facilitates Mitotic Progression	10	1.65e-01	-0.254000	2.16e-01
Autodegradation of Cdh1 by Cdh1:APC/C	62	5.65e-04	-0.253000	1.91e-03
Signaling by Receptor Tyrosine Kinases	492	5.55e-22	-0.253000	3.26e-20
CDK-mediated phosphorylation and removal of Cdc6	71	2.27e-04	-0.253000	8.86e-04
Transcriptional Regulation by TP53	346	5.78e-16	-0.253000	2.45e-14
Cross-presentation of soluble exogenous antigens (endosomes)	48	2.49e-03	-0.252000	6.65e-03
Activation of the pre-replicative complex	31	1.52e-02	-0.252000	3.04e-02
WNT5A-dependent internalization of FZD4	15	9.12e-02	-0.252000	1.33e-01
PI3K Cascade	43	4.28e-03	-0.252000	1.05e-02
Regulation of TP53 Expression and Degradation	37	8.28e-03	-0.251000	1.83e-02
Intrinsic Pathway for Apoptosis	52	1.76e-03	-0.251000	5.07e-03
Protein folding	96	2.24e-05	-0.250000	1.36e-04
Stabilization of p53	55	1.34e-03	-0.250000	4.01e-03
Reduction of cytosolic Ca++ levels	11	1.51e-01	-0.250000	2.02e-01
Synthesis, secretion, and deacylation of Ghrelin	19	5.94e-02	-0.250000	9.40e-02
IGF1R signaling cascade	51	2.03e-03	-0.250000	5.65e-03
MAP kinase activation	58	1.01e-03	-0.250000	3.10e-03
Non-integrin membrane-ECM interactions	40	6.32e-03	-0.249000	1.44e-02
Circadian Clock	69	3.38e-04	-0.249000	1.25e-03
tRNA modification in the nucleus and cytosol	38	7.80e-03	-0.249000	1.73e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	1.35e-01	-0.249000	1.84e-01
DNA strand elongation	31	1.65e-02	-0.249000	3.26e-02
Signaling by NOTCH3	48	2.87e-03	-0.249000	7.49e-03
Transcription of E2F targets under negative control by DREAM complex	19	6.07e-02	-0.248000	9.54e-02
Glycogen breakdown (glycogenolysis)	12	1.36e-01	-0.248000	1.85e-01
Adenylate cyclase inhibitory pathway	14	1.08e-01	-0.248000	1.53e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	1.21e-01	-0.248000	1.69e-01
Aspirin ADME	44	4.38e-03	0.248000	1.06e-02
HCMV Infection	79	1.36e-04	-0.248000	5.92e-04
G alpha (z) signalling events	48	2.93e-03	-0.248000	7.60e-03
Dectin-2 family	28	2.32e-02	0.248000	4.33e-02
L1CAM interactions	92	4.00e-05	-0.248000	2.17e-04
Regulation of TP53 Degradation	36	1.01e-02	-0.247000	2.17e-02
Calcitonin-like ligand receptors	10	1.76e-01	-0.247000	2.28e-01
Selenoamino acid metabolism	103	1.47e-05	-0.247000	9.81e-05
Transport of Mature mRNA derived from an Intron-Containing Transcript	67	4.76e-04	-0.247000	1.66e-03
Dissolution of Fibrin Clot	13	1.24e-01	0.247000	1.71e-01
Activation of kainate receptors upon glutamate binding	29	2.15e-02	-0.247000	4.04e-02
Respiratory electron transport	90	5.28e-05	-0.246000	2.71e-04
Insulin receptor signalling cascade	53	1.92e-03	-0.246000	5.43e-03
Killing mechanisms	11	1.57e-01	-0.246000	2.08e-01
WNT5:FZD7-mediated leishmania damping	11	1.57e-01	-0.246000	2.08e-01
Signaling by NTRK3 (TRKC)	17	7.90e-02	-0.246000	1.18e-01
Transport of organic anions	10	1.78e-01	0.246000	2.30e-01
Fertilization	26	2.99e-02	0.246000	5.33e-02
Inositol phosphate metabolism	45	4.37e-03	-0.245000	1.06e-02
Epigenetic regulation of gene expression	83	1.13e-04	-0.245000	5.04e-04
Defective B3GALTL causes PpS	36	1.09e-02	-0.245000	2.32e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	87	7.99e-05	-0.244000	3.80e-04
Activated point mutants of FGFR2	16	9.06e-02	-0.244000	1.33e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	52	2.30e-03	-0.244000	6.20e-03
SUMOylation of transcription cofactors	43	5.64e-03	-0.244000	1.31e-02
TICAM1, RIP1-mediated IKK complex recruitment	18	7.33e-02	-0.244000	1.11e-01
Signaling by FLT3 fusion proteins	19	6.59e-02	-0.244000	1.02e-01
Gene expression (Transcription)	1407	1.05e-53	-0.244000	5.37e-51
Dectin-1 mediated noncanonical NF-kB signaling	60	1.11e-03	-0.243000	3.40e-03
Switching of origins to a post-replicative state	90	6.73e-05	-0.243000	3.28e-04
Unfolded Protein Response (UPR)	91	6.35e-05	-0.242000	3.13e-04
FRS-mediated FGFR1 signaling	23	4.45e-02	-0.242000	7.44e-02
Major pathway of rRNA processing in the nucleolus and cytosol	171	4.63e-08	-0.242000	6.50e-07
Glycolysis	68	5.58e-04	-0.242000	1.89e-03
Metal ion SLC transporters	25	3.62e-02	-0.242000	6.27e-02
Apoptosis	164	8.92e-08	-0.242000	1.18e-06
COPI-independent Golgi-to-ER retrograde traffic	34	1.47e-02	-0.242000	2.97e-02
Signaling by cytosolic FGFR1 fusion mutants	17	8.47e-02	-0.241000	1.25e-01
APC/C:Cdc20 mediated degradation of Securin	66	6.92e-04	-0.241000	2.24e-03
Synthesis of DNA	118	5.95e-06	-0.241000	4.77e-05
TP53 Regulates Metabolic Genes	83	1.45e-04	-0.241000	6.17e-04
RHO GTPases Activate WASPs and WAVEs	34	1.50e-02	-0.241000	3.02e-02
IRS-related events triggered by IGF1R	50	3.23e-03	-0.241000	8.22e-03
NRAGE signals death through JNK	53	2.44e-03	-0.241000	6.54e-03
ADP signalling through P2Y purinoceptor 12	22	5.11e-02	-0.240000	8.30e-02
Meiosis	56	1.88e-03	-0.240000	5.37e-03
Regulation of TP53 Activity	154	2.69e-07	-0.240000	3.06e-06
Reversible hydration of carbon dioxide	11	1.69e-01	-0.240000	2.20e-01
Transport to the Golgi and subsequent modification	165	1.12e-07	-0.239000	1.42e-06
Sensory Perception	576	8.04e-23	0.239000	5.59e-21
Telomere Extension By Telomerase	22	5.24e-02	-0.239000	8.45e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	4.28e-02	-0.239000	7.21e-02
IRS-mediated signalling	47	4.69e-03	-0.238000	1.12e-02
RHO GTPase cycle	421	4.25e-17	-0.238000	1.91e-15
Neurotoxicity of clostridium toxins	10	1.92e-01	-0.238000	2.47e-01
RNA Polymerase II Transcription	1271	1.52e-46	-0.237000	4.64e-44
Toll Like Receptor 4 (TLR4) Cascade	124	4.95e-06	-0.237000	4.27e-05
Fatty acyl-CoA biosynthesis	35	1.53e-02	-0.237000	3.05e-02
Mismatch Repair	15	1.13e-01	-0.236000	1.60e-01
PD-1 signaling	21	6.07e-02	0.236000	9.54e-02
RHOBTB GTPase Cycle	34	1.70e-02	-0.236000	3.35e-02
Activation of BAD and translocation to mitochondria	15	1.13e-01	-0.236000	1.60e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	1.57e-01	-0.236000	2.07e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	95	6.99e-05	-0.236000	3.38e-04
MAPK1/MAPK3 signaling	271	2.21e-11	-0.236000	5.53e-10
Chaperonin-mediated protein folding	90	1.10e-04	-0.236000	4.94e-04
Signaling by FGFR4	40	9.90e-03	-0.236000	2.12e-02
Glucose metabolism	87	1.44e-04	-0.236000	6.14e-04
mRNA Splicing - Minor Pathway	53	3.04e-03	-0.235000	7.87e-03
Potential therapeutics for SARS	83	2.13e-04	-0.235000	8.52e-04
PLC beta mediated events	47	5.41e-03	-0.234000	1.26e-02
Metabolism of proteins	1774	1.52e-61	-0.234000	1.16e-58
Global Genome Nucleotide Excision Repair (GG-NER)	81	2.67e-04	-0.234000	1.02e-03
Signaling by Nuclear Receptors	237	5.03e-10	-0.234000	9.49e-09
RAF/MAP kinase cascade	265	5.07e-11	-0.234000	1.17e-09
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	1.17e-01	-0.234000	1.64e-01
Membrane Trafficking	586	3.48e-22	-0.233000	2.13e-20
KEAP1-NFE2L2 pathway	103	4.24e-05	-0.233000	2.25e-04
NCAM signaling for neurite out-growth	57	2.32e-03	-0.233000	6.23e-03
Presynaptic function of Kainate receptors	21	6.43e-02	-0.233000	1.00e-01
MAPK family signaling cascades	312	1.31e-12	-0.233000	3.70e-11
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	1.07e-01	-0.233000	1.52e-01
Unwinding of DNA	12	1.63e-01	-0.233000	2.14e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	21	6.48e-02	-0.233000	1.01e-01
Translesion Synthesis by POLH	19	7.94e-02	-0.232000	1.19e-01
RHOA GTPase cycle	140	2.06e-06	-0.232000	1.98e-05
PKA activation	18	8.81e-02	-0.232000	1.30e-01
Transcriptional Regulation by E2F6	32	2.30e-02	-0.232000	4.30e-02
SUMOylation of DNA methylation proteins	16	1.08e-01	-0.232000	1.53e-01
Generic Transcription Pathway	1150	1.21e-40	-0.232000	2.30e-38
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	1.33e-01	-0.232000	1.81e-01
Eicosanoids	12	1.64e-01	0.232000	2.15e-01
Myogenesis	29	3.10e-02	-0.231000	5.50e-02
Uptake and actions of bacterial toxins	29	3.10e-02	-0.231000	5.50e-02
Negative regulators of DDX58/IFIH1 signaling	34	1.96e-02	-0.231000	3.75e-02
TICAM1-dependent activation of IRF3/IRF7	12	1.66e-01	-0.231000	2.17e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	6.95e-04	-0.231000	2.24e-03
Molecules associated with elastic fibres	30	2.85e-02	-0.231000	5.13e-02
CD28 co-stimulation	32	2.41e-02	-0.230000	4.48e-02
PINK1-PRKN Mediated Mitophagy	21	6.80e-02	-0.230000	1.05e-01
G beta:gamma signalling through PLC beta	20	7.52e-02	-0.230000	1.14e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	2.08e-01	-0.230000	2.64e-01
Cellular response to starvation	147	1.62e-06	-0.229000	1.63e-05
Bicarbonate transporters	10	2.10e-01	-0.229000	2.65e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	2.10e-01	-0.229000	2.65e-01
Sphingolipid metabolism	81	3.77e-04	-0.228000	1.37e-03
Cellular responses to stress	683	2.32e-24	-0.228000	1.77e-22
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	12	1.72e-01	-0.228000	2.24e-01
PI3K/AKT Signaling in Cancer	103	6.69e-05	-0.227000	3.27e-04
Activation of Matrix Metalloproteinases	31	2.85e-02	0.227000	5.14e-02
Disease	1624	4.22e-53	-0.226000	1.61e-50
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.43e-01	-0.226000	1.92e-01
Complex I biogenesis	49	6.22e-03	-0.226000	1.43e-02
Sialic acid metabolism	33	2.54e-02	-0.225000	4.67e-02
SHC-mediated cascade:FGFR1	21	7.46e-02	-0.225000	1.13e-01
rRNA processing in the nucleus and cytosol	180	1.98e-07	-0.225000	2.40e-06
PKA-mediated phosphorylation of CREB	19	9.02e-02	-0.224000	1.32e-01
O-glycosylation of TSR domain-containing proteins	37	1.82e-02	-0.224000	3.52e-02
Receptor Mediated Mitophagy	10	2.20e-01	-0.224000	2.75e-01
rRNA processing	186	1.32e-07	-0.224000	1.64e-06
Post-translational protein modification	1294	3.79e-42	-0.224000	9.65e-40
Deadenylation of mRNA	25	5.33e-02	-0.223000	8.55e-02
DNA Double Strand Break Response	42	1.23e-02	-0.223000	2.54e-02
Infectious disease	885	1.13e-29	-0.223000	1.24e-27
Cellular responses to stimuli	697	7.24e-24	-0.223000	5.27e-22
Recycling pathway of L1	23	6.40e-02	-0.223000	1.00e-01
Neuronal System	371	1.47e-13	-0.223000	4.78e-12
Prolonged ERK activation events	14	1.49e-01	-0.223000	1.99e-01
Cellular response to chemical stress	187	1.47e-07	-0.223000	1.81e-06
Glycogen synthesis	15	1.36e-01	-0.222000	1.84e-01
IRF3-mediated induction of type I IFN	11	2.02e-01	-0.222000	2.58e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	1.82e-01	-0.222000	2.35e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	2.51e-02	-0.222000	4.63e-02
Trafficking and processing of endosomal TLR	11	2.03e-01	0.222000	2.59e-01
Effects of PIP2 hydrolysis	26	5.05e-02	-0.222000	8.24e-02
Signaling by the B Cell Receptor (BCR)	105	8.68e-05	-0.221000	4.10e-04
Phospholipase C-mediated cascade: FGFR1	16	1.25e-01	-0.221000	1.73e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	5.54e-02	-0.221000	8.86e-02
IKK complex recruitment mediated by RIP1	22	7.24e-02	-0.221000	1.10e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	23	6.65e-02	-0.221000	1.03e-01
Cardiac conduction	120	2.90e-05	-0.221000	1.69e-04
Signaling by Non-Receptor Tyrosine Kinases	55	4.61e-03	-0.221000	1.10e-02
Signaling by PTK6	55	4.61e-03	-0.221000	1.10e-02
HCMV Late Events	54	5.00e-03	-0.221000	1.17e-02
FGFR1c ligand binding and activation	11	2.05e-01	-0.220000	2.61e-01
Signaling by activated point mutants of FGFR1	11	2.05e-01	-0.220000	2.61e-01
Cargo recognition for clathrin-mediated endocytosis	98	1.65e-04	-0.220000	6.83e-04
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	2.06e-01	-0.220000	2.62e-01
ER-Phagosome pathway	87	3.91e-04	-0.220000	1.41e-03
A tetrasaccharide linker sequence is required for GAG synthesis	23	6.82e-02	-0.220000	1.05e-01
Erythropoietin activates RAS	14	1.55e-01	-0.220000	2.05e-01
Interleukin-17 signaling	66	2.07e-03	-0.219000	5.72e-03
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	120	3.39e-05	0.219000	1.91e-04
RAC1 GTPase cycle	170	8.33e-07	-0.219000	8.84e-06
Regulation of lipid metabolism by PPARalpha	116	4.74e-05	-0.218000	2.48e-04
Listeria monocytogenes entry into host cells	19	9.93e-02	-0.218000	1.43e-01
Clathrin-mediated endocytosis	135	1.19e-05	-0.218000	8.24e-05
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	41	1.58e-02	-0.218000	3.14e-02
Constitutive Signaling by EGFRvIII	15	1.44e-01	-0.218000	1.93e-01
Signaling by EGFRvIII in Cancer	15	1.44e-01	-0.218000	1.93e-01
Apoptotic cleavage of cellular proteins	35	2.57e-02	-0.218000	4.71e-02
Collagen biosynthesis and modifying enzymes	65	2.40e-03	-0.218000	6.44e-03
Intra-Golgi traffic	43	1.37e-02	-0.217000	2.81e-02
Apoptotic execution phase	43	1.39e-02	-0.217000	2.83e-02
Collagen formation	88	4.36e-04	-0.217000	1.54e-03
Butyrophilin (BTN) family interactions	12	1.93e-01	0.217000	2.48e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	1.22e-01	-0.217000	1.69e-01
Synthesis of glycosylphosphatidylinositol (GPI)	17	1.22e-01	-0.217000	1.69e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	23	7.21e-02	-0.217000	1.10e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	23	7.21e-02	-0.217000	1.10e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	23	7.21e-02	-0.217000	1.10e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	23	7.21e-02	-0.217000	1.10e-01
Impaired BRCA2 binding to PALB2	23	7.21e-02	-0.217000	1.10e-01
Cellular Senescence	130	2.01e-05	-0.216000	1.26e-04
Negative regulation of the PI3K/AKT network	111	8.19e-05	-0.216000	3.89e-04
Synthesis of PIPs at the plasma membrane	48	9.53e-03	-0.216000	2.06e-02
Insulin processing	26	5.64e-02	-0.216000	8.99e-02
Regulation of commissural axon pathfinding by SLIT and ROBO	10	2.37e-01	-0.216000	2.95e-01
Regulation of PTEN mRNA translation	25	6.16e-02	0.216000	9.66e-02
ABC-family proteins mediated transport	98	2.20e-04	-0.216000	8.63e-04
Zinc transporters	17	1.24e-01	-0.216000	1.71e-01
Intracellular signaling by second messengers	313	5.38e-11	-0.215000	1.23e-09
The citric acid (TCA) cycle and respiratory electron transport	143	8.74e-06	-0.215000	6.53e-05
Cyclin D associated events in G1	46	1.17e-02	-0.215000	2.43e-02
G1 Phase	46	1.17e-02	-0.215000	2.43e-02
PPARA activates gene expression	114	7.38e-05	-0.215000	3.53e-04
Nuclear Envelope (NE) Reassembly	73	1.55e-03	-0.214000	4.54e-03
Gene Silencing by RNA	80	9.25e-04	-0.214000	2.87e-03
GPER1 signaling	44	1.40e-02	-0.214000	2.85e-02
G beta:gamma signalling through BTK	17	1.27e-01	-0.214000	1.74e-01
FCERI mediated MAPK activation	29	4.67e-02	-0.213000	7.74e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	104	1.69e-04	-0.213000	6.98e-04
Triglyceride catabolism	23	7.68e-02	-0.213000	1.16e-01
Vesicle-mediated transport	624	8.28e-20	-0.213000	4.69e-18
Transcriptional regulation by RUNX1	183	6.90e-07	-0.213000	7.47e-06
Signalling to ERKs	34	3.26e-02	-0.212000	5.74e-02
Gluconeogenesis	32	3.86e-02	-0.211000	6.57e-02
Regulation of TLR by endogenous ligand	17	1.32e-01	0.211000	1.81e-01
Assembly of collagen fibrils and other multimeric structures	56	6.38e-03	-0.211000	1.45e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	1.33e-01	-0.211000	1.81e-01
Ovarian tumor domain proteases	36	2.89e-02	-0.210000	5.18e-02
RHO GTPases activate PKNs	34	3.38e-02	-0.210000	5.91e-02
Signal Transduction	2408	3.33e-65	-0.210000	5.09e-62
Signaling by SCF-KIT	43	1.73e-02	-0.210000	3.38e-02
Phase 2 - plateau phase	14	1.75e-01	-0.209000	2.27e-01
Signaling by ERBB2 KD Mutants	24	7.60e-02	-0.209000	1.15e-01
Regulation of PTEN gene transcription	59	5.50e-03	-0.209000	1.28e-02
Lysosome Vesicle Biogenesis	33	3.84e-02	-0.208000	6.55e-02
Presynaptic depolarization and calcium channel opening	12	2.12e-01	-0.208000	2.67e-01
CLEC7A (Dectin-1) signaling	96	4.27e-04	-0.208000	1.51e-03
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14	1.78e-01	-0.208000	2.30e-01
Inactivation of CSF3 (G-CSF) signaling	23	8.47e-02	-0.208000	1.25e-01
Interleukin-1 family signaling	134	3.30e-05	-0.208000	1.86e-04
Frs2-mediated activation	12	2.15e-01	-0.207000	2.70e-01
RHOQ GTPase cycle	57	7.14e-03	-0.206000	1.61e-02
Oxidative Stress Induced Senescence	66	3.82e-03	-0.206000	9.42e-03
RHOH GTPase cycle	36	3.30e-02	-0.205000	5.80e-02
ABC transporter disorders	75	2.12e-03	-0.205000	5.83e-03
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	94	5.87e-04	-0.205000	1.96e-03
Toll Like Receptor 2 (TLR2) Cascade	94	5.87e-04	-0.205000	1.96e-03
Toll Like Receptor TLR1:TLR2 Cascade	94	5.87e-04	-0.205000	1.96e-03
Toll Like Receptor TLR6:TLR2 Cascade	94	5.87e-04	-0.205000	1.96e-03
Transmission across Chemical Synapses	237	5.22e-08	-0.205000	7.25e-07
Apoptotic factor-mediated response	17	1.44e-01	-0.205000	1.93e-01
Trafficking of GluR2-containing AMPA receptors	15	1.70e-01	-0.205000	2.22e-01
SARS-CoV Infections	339	8.94e-11	-0.205000	1.87e-09
Constitutive Signaling by Overexpressed ERBB2	10	2.64e-01	-0.204000	3.24e-01
Metabolism of nucleotides	95	5.86e-04	-0.204000	1.96e-03
Iron uptake and transport	57	7.76e-03	-0.204000	1.73e-02
p75NTR recruits signalling complexes	12	2.22e-01	-0.204000	2.77e-01
Recycling of bile acids and salts	18	1.35e-01	0.203000	1.84e-01
Removal of the Flap Intermediate from the C-strand	17	1.46e-01	-0.203000	1.96e-01
PKMTs methylate histone lysines	37	3.23e-02	-0.203000	5.70e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	1.73e-01	-0.203000	2.25e-01
PKA activation in glucagon signalling	17	1.47e-01	-0.203000	1.97e-01
Removal of the Flap Intermediate	13	2.05e-01	-0.203000	2.61e-01
MET promotes cell motility	29	5.89e-02	-0.203000	9.34e-02
PERK regulates gene expression	32	4.75e-02	-0.202000	7.86e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	32	4.77e-02	-0.202000	7.87e-02
Potassium Channels	102	4.16e-04	-0.202000	1.48e-03
CDC42 GTPase cycle	144	2.82e-05	-0.202000	1.65e-04
SARS-CoV-2 Infection	265	1.52e-08	-0.202000	2.34e-07
FCGR3A-mediated phagocytosis	57	8.49e-03	-0.201000	1.87e-02
Leishmania phagocytosis	57	8.49e-03	-0.201000	1.87e-02
Parasite infection	57	8.49e-03	-0.201000	1.87e-02
RAC2 GTPase cycle	80	1.83e-03	-0.201000	5.25e-03
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	1.51e-01	-0.201000	2.01e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	3.66e-02	-0.201000	6.31e-02
mRNA decay by 3’ to 5’ exoribonuclease	16	1.64e-01	-0.201000	2.15e-01
Synthesis of PC	27	7.06e-02	-0.201000	1.08e-01
Maturation of nucleoprotein	11	2.49e-01	-0.201000	3.07e-01
G alpha (12/13) signalling events	74	2.82e-03	-0.201000	7.37e-03
Signaling by FGFR1	49	1.51e-02	-0.201000	3.02e-02
Signal amplification	33	4.61e-02	-0.200000	7.68e-02
NOTCH3 Intracellular Domain Regulates Transcription	24	8.90e-02	-0.200000	1.31e-01
Signaling by Insulin receptor	76	2.51e-03	-0.200000	6.66e-03
PIP3 activates AKT signaling	275	1.07e-08	-0.200000	1.67e-07
Defective GALNT12 causes CRCS1	18	1.42e-01	0.200000	1.91e-01
Downregulation of TGF-beta receptor signaling	26	7.74e-02	-0.200000	1.16e-01
Diseases of glycosylation	137	5.28e-05	-0.200000	2.71e-04
Selective autophagy	59	7.94e-03	-0.200000	1.76e-02
IRAK4 deficiency (TLR2/4)	17	1.54e-01	0.200000	2.04e-01
Cellular response to heat stress	95	7.71e-04	-0.200000	2.44e-03
Common Pathway of Fibrin Clot Formation	21	1.13e-01	0.199000	1.60e-01
Fcgamma receptor (FCGR) dependent phagocytosis	82	1.81e-03	-0.199000	5.20e-03
Meiotic synapsis	32	5.17e-02	-0.199000	8.37e-02
Glucagon signaling in metabolic regulation	33	4.87e-02	-0.198000	8.01e-02
Downstream TCR signaling	92	1.02e-03	-0.198000	3.12e-03
Glutathione synthesis and recycling	13	2.19e-01	-0.197000	2.75e-01
Rab regulation of trafficking	114	2.81e-04	-0.197000	1.07e-03
Glycogen metabolism	24	9.57e-02	-0.196000	1.39e-01
Positive epigenetic regulation of rRNA expression	43	2.59e-02	-0.196000	4.73e-02
Signaling by BRAF and RAF1 fusions	60	8.78e-03	-0.195000	1.92e-02
ER Quality Control Compartment (ERQC)	20	1.30e-01	-0.195000	1.78e-01
Regulation of HSF1-mediated heat shock response	78	2.88e-03	-0.195000	7.49e-03
Pyruvate metabolism and Citric Acid (TCA) cycle	52	1.50e-02	-0.195000	3.02e-02
Signal regulatory protein family interactions	13	2.24e-01	0.195000	2.80e-01
SARS-CoV-2 modulates host translation machinery	46	2.25e-02	-0.194000	4.20e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	9.25e-02	-0.194000	1.35e-01
TAK1-dependent IKK and NF-kappa-B activation	25	9.26e-02	-0.194000	1.35e-01
Chondroitin sulfate/dermatan sulfate metabolism	45	2.41e-02	-0.194000	4.48e-02
RNA Polymerase I Transcription Initiation	42	2.93e-02	-0.194000	5.26e-02
Protein localization	147	4.75e-05	-0.194000	2.48e-04
Prostacyclin signalling through prostacyclin receptor	19	1.43e-01	-0.194000	1.93e-01
Activation of GABAB receptors	43	2.79e-02	-0.194000	5.03e-02
GABA B receptor activation	43	2.79e-02	-0.194000	5.03e-02
Constitutive Signaling by Aberrant PI3K in Cancer	77	3.34e-03	-0.193000	8.41e-03
Factors involved in megakaryocyte development and platelet production	130	1.47e-04	-0.193000	6.21e-04
Diseases of mitotic cell cycle	37	4.29e-02	-0.192000	7.21e-02
FLT3 Signaling	38	4.04e-02	-0.192000	6.84e-02
ATF6 (ATF6-alpha) activates chaperones	11	2.70e-01	-0.192000	3.31e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	31	6.54e-02	-0.191000	1.02e-01
ATF4 activates genes in response to endoplasmic reticulum stress	28	8.00e-02	-0.191000	1.19e-01
Signaling by FGFR3	39	3.94e-02	-0.191000	6.70e-02
Interleukin-6 family signaling	24	1.06e-01	-0.190000	1.52e-01
Nuclear events stimulated by ALK signaling in cancer	18	1.62e-01	-0.190000	2.14e-01
Programmed Cell Death	192	5.41e-06	-0.190000	4.50e-05
Response of Mtb to phagocytosis	22	1.23e-01	-0.190000	1.70e-01
Nucleotide catabolism	35	5.27e-02	-0.189000	8.47e-02
G beta:gamma signalling through CDC42	19	1.54e-01	-0.189000	2.04e-01
mTORC1-mediated signalling	23	1.18e-01	-0.188000	1.65e-01
RNA Polymerase I Transcription	47	2.57e-02	-0.188000	4.71e-02
Nuclear Receptor transcription pathway	51	2.02e-02	-0.188000	3.85e-02
Toll-like Receptor Cascades	143	1.06e-04	-0.188000	4.81e-04
SARS-CoV-2-host interactions	185	1.08e-05	-0.187000	7.60e-05
Processive synthesis on the C-strand of the telomere	19	1.58e-01	-0.187000	2.08e-01
RHOBTB2 GTPase cycle	22	1.29e-01	-0.187000	1.76e-01
FGFR1 ligand binding and activation	15	2.10e-01	-0.187000	2.65e-01
Zinc influx into cells by the SLC39 gene family	10	3.06e-01	-0.187000	3.68e-01
Calnexin/calreticulin cycle	25	1.06e-01	-0.187000	1.52e-01
E2F mediated regulation of DNA replication	20	1.49e-01	-0.186000	2.00e-01
Resolution of D-Loop Structures	32	6.84e-02	-0.186000	1.05e-01
Interconversion of nucleotide di- and triphosphates	29	8.31e-02	-0.186000	1.23e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	3.09e-01	-0.186000	3.71e-01
Cholesterol biosynthesis	24	1.15e-01	-0.186000	1.63e-01
Regulation of signaling by NODAL	11	2.87e-01	0.186000	3.47e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	3.10e-01	-0.186000	3.72e-01
Peroxisomal lipid metabolism	28	8.94e-02	-0.185000	1.31e-01
FCERI mediated Ca+2 mobilization	27	9.59e-02	-0.185000	1.39e-01
COPII-mediated vesicle transport	66	9.35e-03	-0.185000	2.03e-02
DAP12 signaling	28	9.08e-02	-0.185000	1.33e-01
Mitophagy	27	9.69e-02	-0.184000	1.40e-01
Plasma lipoprotein clearance	37	5.23e-02	-0.184000	8.45e-02
Role of phospholipids in phagocytosis	23	1.27e-01	-0.184000	1.74e-01
Cell-Cell communication	112	7.71e-04	-0.184000	2.44e-03
RHO GTPases Activate ROCKs	19	1.67e-01	-0.183000	2.18e-01
Sphingolipid de novo biosynthesis	41	4.36e-02	-0.182000	7.31e-02
WNT ligand biogenesis and trafficking	25	1.16e-01	-0.182000	1.63e-01
Downregulation of ERBB2:ERBB3 signaling	13	2.57e-01	-0.181000	3.17e-01
Metabolism of amino acids and derivatives	345	6.70e-09	-0.181000	1.07e-07
Metabolism of carbohydrates	275	2.36e-07	-0.181000	2.74e-06
IL-6-type cytokine receptor ligand interactions	17	1.97e-01	-0.181000	2.52e-01
Developmental Biology	1020	1.35e-22	-0.180000	8.81e-21
Glycosaminoglycan metabolism	116	8.25e-04	-0.180000	2.58e-03
RNA Polymerase I Promoter Clearance	46	3.53e-02	-0.179000	6.15e-02
Notch-HLH transcription pathway	24	1.29e-01	-0.179000	1.76e-01
FGFR2 ligand binding and activation	19	1.77e-01	-0.179000	2.29e-01
MET activates PTK2 signaling	18	1.89e-01	-0.179000	2.43e-01
Senescence-Associated Secretory Phenotype (SASP)	53	2.44e-02	-0.179000	4.51e-02
Cytochrome c-mediated apoptotic response	12	2.84e-01	-0.179000	3.45e-01
FLT3 signaling in disease	28	1.02e-01	-0.178000	1.46e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	15	2.32e-01	-0.178000	2.90e-01
Signaling by ERBB2 in Cancer	25	1.24e-01	-0.178000	1.71e-01
Regulation of gene expression by Hypoxia-inducible Factor	11	3.08e-01	-0.178000	3.70e-01
Vasopressin regulates renal water homeostasis via Aquaporins	42	4.71e-02	-0.177000	7.80e-02
Infection with Mycobacterium tuberculosis	26	1.18e-01	-0.177000	1.66e-01
G-protein beta:gamma signalling	30	9.36e-02	-0.177000	1.36e-01
Growth hormone receptor signaling	24	1.35e-01	-0.176000	1.84e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	3.12e-01	-0.176000	3.74e-01
G beta:gamma signalling through PI3Kgamma	25	1.29e-01	-0.175000	1.77e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	1.02e-01	-0.175000	1.46e-01
Trafficking of AMPA receptors	29	1.02e-01	-0.175000	1.46e-01
Fatty acid metabolism	167	9.32e-05	-0.175000	4.31e-04
Semaphorin interactions	61	1.81e-02	-0.175000	3.51e-02
TNFR2 non-canonical NF-kB pathway	94	3.42e-03	-0.175000	8.50e-03
PTEN Regulation	150	2.25e-04	-0.174000	8.78e-04
Mitochondrial calcium ion transport	22	1.57e-01	-0.174000	2.07e-01
The role of Nef in HIV-1 replication and disease pathogenesis	27	1.17e-01	-0.174000	1.64e-01
Collagen chain trimerization	42	5.17e-02	-0.173000	8.37e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	6.80e-02	-0.173000	1.05e-01
Integrin cell surface interactions	66	1.50e-02	-0.173000	3.02e-02
Diseases associated with glycosaminoglycan metabolism	38	6.50e-02	-0.173000	1.01e-01
DNA Damage Recognition in GG-NER	36	7.48e-02	-0.172000	1.13e-01
Signaling by ERBB2	49	3.78e-02	-0.171000	6.48e-02
Purine catabolism	17	2.21e-01	-0.171000	2.77e-01
STING mediated induction of host immune responses	13	2.90e-01	-0.170000	3.51e-01
Disorders of transmembrane transporters	167	1.55e-04	-0.170000	6.49e-04
Neurotransmitter receptors and postsynaptic signal transmission	175	1.10e-04	-0.169000	4.94e-04
Signal transduction by L1	20	1.90e-01	-0.169000	2.44e-01
Class B/2 (Secretin family receptors)	94	4.66e-03	-0.169000	1.11e-02
Interleukin-37 signaling	21	1.81e-01	-0.169000	2.33e-01
PI Metabolism	79	9.54e-03	-0.169000	2.06e-02
Smooth Muscle Contraction	39	6.87e-02	-0.168000	1.05e-01
Regulation of insulin secretion	77	1.09e-02	-0.168000	2.32e-02
Negative regulation of FGFR4 signaling	30	1.13e-01	-0.167000	1.60e-01
RHOG GTPase cycle	69	1.63e-02	-0.167000	3.23e-02
Activation of G protein gated Potassium channels	29	1.19e-01	-0.167000	1.66e-01
G protein gated Potassium channels	29	1.19e-01	-0.167000	1.66e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	29	1.19e-01	-0.167000	1.66e-01
Metabolism of lipids	696	4.74e-14	-0.167000	1.61e-12
Depolymerisation of the Nuclear Lamina	14	2.80e-01	-0.167000	3.42e-01
GABA receptor activation	57	2.96e-02	-0.167000	5.28e-02
Signaling by MET	66	1.96e-02	-0.166000	3.75e-02
InlB-mediated entry of Listeria monocytogenes into host cell	14	2.83e-01	-0.166000	3.45e-01
Azathioprine ADME	22	1.79e-01	-0.165000	2.31e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	1.53e-01	-0.165000	2.03e-01
FGFR3 ligand binding and activation	12	3.22e-01	-0.165000	3.84e-01
FGFR3c ligand binding and activation	12	3.22e-01	-0.165000	3.84e-01
SHC1 events in ERBB4 signaling	14	2.85e-01	-0.165000	3.46e-01
Defective C1GALT1C1 causes TNPS	18	2.26e-01	0.165000	2.82e-01
Acetylcholine regulates insulin secretion	10	3.68e-01	0.164000	4.31e-01
Cell junction organization	79	1.15e-02	-0.164000	2.41e-02
Signaling by EGFR	49	4.65e-02	-0.164000	7.73e-02
MET activates RAS signaling	11	3.46e-01	-0.164000	4.07e-01
Interleukin receptor SHC signaling	24	1.65e-01	-0.164000	2.16e-01
Class I peroxisomal membrane protein import	19	2.17e-01	-0.163000	2.73e-01
Metabolism	1967	1.31e-33	-0.163000	1.82e-31
RAB GEFs exchange GTP for GDP on RABs	83	1.02e-02	-0.163000	2.18e-02
HuR (ELAVL1) binds and stabilizes mRNA	10	3.74e-01	-0.162000	4.36e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	112	3.19e-03	-0.161000	8.15e-03
PI3K events in ERBB4 signaling	10	3.77e-01	-0.161000	4.39e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	2.13e-01	-0.161000	2.68e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	1.05e-01	-0.161000	1.50e-01
Muscle contraction	186	1.70e-04	-0.160000	7.02e-04
Integration of energy metabolism	106	4.78e-03	-0.159000	1.13e-02
Suppression of phagosomal maturation	13	3.24e-01	-0.158000	3.85e-01
ADP signalling through P2Y purinoceptor 1	25	1.72e-01	-0.158000	2.24e-01
Regulation of actin dynamics for phagocytic cup formation	59	3.69e-02	-0.157000	6.35e-02
HDL remodeling	10	3.91e-01	-0.157000	4.53e-01
PI3K events in ERBB2 signaling	16	2.81e-01	-0.156000	3.43e-01
Integrin signaling	27	1.63e-01	-0.155000	2.14e-01
Nuclear signaling by ERBB4	32	1.30e-01	-0.155000	1.78e-01
TCR signaling	112	4.70e-03	-0.154000	1.12e-02
Adherens junctions interactions	26	1.73e-01	-0.154000	2.25e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	101	7.58e-03	-0.154000	1.69e-02
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	29	1.52e-01	-0.154000	2.02e-01
Triglyceride metabolism	36	1.12e-01	-0.153000	1.59e-01
Processing of SMDT1	15	3.06e-01	-0.153000	3.68e-01
Josephin domain DUBs	11	3.81e-01	-0.152000	4.43e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	2.78e-01	-0.152000	3.40e-01
Macroautophagy	111	5.73e-03	-0.152000	1.33e-02
Signaling by ERBB2 TMD/JMD mutants	21	2.30e-01	-0.151000	2.87e-01
Synthesis of very long-chain fatty acyl-CoAs	23	2.10e-01	-0.151000	2.65e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	2.69e-01	-0.150000	3.31e-01
Negative regulation of FGFR2 signaling	33	1.35e-01	-0.150000	1.84e-01
TP53 Regulates Transcription of Cell Death Genes	42	9.24e-02	-0.150000	1.35e-01
Aggrephagy	23	2.13e-01	-0.150000	2.68e-01
Antigen processing-Cross presentation	102	8.94e-03	-0.150000	1.95e-02
Formation of tubulin folding intermediates by CCT/TriC	26	1.87e-01	-0.150000	2.40e-01
CS/DS degradation	12	3.71e-01	-0.149000	4.34e-01
Signaling by ERBB4	57	5.20e-02	-0.149000	8.40e-02
Pyrimidine catabolism	12	3.72e-01	-0.149000	4.35e-01
Vitamin D (calciferol) metabolism	12	3.73e-01	-0.148000	4.36e-01
Tryptophan catabolism	12	3.74e-01	0.148000	4.36e-01
Interleukin-12 family signaling	54	6.06e-02	-0.148000	9.53e-02
SARS-CoV-1 Infection	51	6.85e-02	-0.147000	1.05e-01
Processive synthesis on the lagging strand	14	3.41e-01	-0.147000	4.02e-01
Generation of second messenger molecules	30	1.65e-01	0.146000	2.16e-01
Pyruvate metabolism	29	1.73e-01	-0.146000	2.25e-01
Assembly of the ORC complex at the origin of replication	10	4.24e-01	-0.146000	4.88e-01
Inwardly rectifying K+ channels	35	1.37e-01	-0.145000	1.86e-01
Sema4D in semaphorin signaling	24	2.19e-01	-0.145000	2.75e-01
Transport of small molecules	689	9.40e-11	-0.144000	1.94e-09
Diseases of metabolism	234	1.42e-04	-0.144000	6.09e-04
Metabolism of vitamins and cofactors	181	8.29e-04	-0.144000	2.59e-03
Ion transport by P-type ATPases	51	7.78e-02	-0.143000	1.17e-01
p38MAPK events	13	3.74e-01	-0.142000	4.36e-01
Ion homeostasis	50	8.27e-02	-0.142000	1.23e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	1.16e-01	-0.142000	1.64e-01
Metabolism of water-soluble vitamins and cofactors	118	7.88e-03	-0.141000	1.75e-02
Miscellaneous substrates	12	3.96e-01	0.141000	4.59e-01
Autophagy	125	6.59e-03	-0.141000	1.50e-02
Abacavir ADME	10	4.42e-01	-0.140000	5.05e-01
Signaling by Retinoic Acid	41	1.21e-01	-0.140000	1.69e-01
SLC transporter disorders	92	2.07e-02	-0.139000	3.91e-02
Budding and maturation of HIV virion	28	2.01e-01	-0.139000	2.57e-01
Lysine catabolism	12	4.04e-01	-0.139000	4.67e-01
Thromboxane signalling through TP receptor	24	2.38e-01	-0.139000	2.96e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	1.51e-01	-0.138000	2.01e-01
Assembly Of The HIV Virion	16	3.39e-01	-0.138000	4.01e-01
EPHA-mediated growth cone collapse	15	3.55e-01	-0.138000	4.17e-01
Negative regulation of FGFR3 signaling	28	2.07e-01	-0.138000	2.62e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	2.78e-01	-0.137000	3.40e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	2.78e-01	-0.137000	3.40e-01
Amino acids regulate mTORC1	52	8.81e-02	-0.137000	1.30e-01
Sema4D induced cell migration and growth-cone collapse	20	2.90e-01	-0.137000	3.51e-01
Nucleotide salvage	21	2.80e-01	-0.136000	3.42e-01
Post-translational protein phosphorylation	100	1.92e-02	-0.135000	3.71e-02
Carnitine metabolism	11	4.37e-01	-0.135000	5.01e-01
Peroxisomal protein import	62	6.57e-02	-0.135000	1.02e-01
Sensory perception of taste	47	1.10e-01	0.135000	1.56e-01
RHO GTPases activate PAKs	19	3.13e-01	-0.134000	3.75e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	3.14e-01	-0.133000	3.75e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	3.14e-01	-0.133000	3.75e-01
Phospholipid metabolism	192	1.42e-03	-0.133000	4.21e-03
Synthesis of IP2, IP, and Ins in the cytosol	13	4.06e-01	-0.133000	4.69e-01
The NLRP3 inflammasome	16	3.58e-01	-0.133000	4.20e-01
Aquaporin-mediated transport	51	1.01e-01	-0.133000	1.46e-01
Pexophagy	11	4.48e-01	-0.132000	5.12e-01
Regulation of RUNX1 Expression and Activity	25	2.54e-01	-0.132000	3.13e-01
Adaptive Immune System	711	2.69e-09	-0.131000	4.62e-08
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	1.51e-01	0.129000	2.02e-01
Synthesis of PIPs at the early endosome membrane	15	3.85e-01	-0.129000	4.47e-01
Aspartate and asparagine metabolism	12	4.38e-01	-0.129000	5.02e-01
Interleukin-12 signaling	44	1.39e-01	-0.129000	1.88e-01
Plasma lipoprotein assembly, remodeling, and clearance	73	5.80e-02	-0.128000	9.20e-02
Stimuli-sensing channels	96	2.99e-02	-0.128000	5.33e-02
Biosynthesis of specialized proresolving mediators (SPMs)	19	3.34e-01	-0.128000	3.95e-01
Sodium/Calcium exchangers	11	4.63e-01	-0.128000	5.25e-01
Extracellular matrix organization	288	1.93e-04	-0.127000	7.82e-04
Organic cation transport	10	4.86e-01	-0.127000	5.48e-01
Signaling by Interleukins	426	6.60e-06	-0.127000	5.12e-05
Transferrin endocytosis and recycling	30	2.32e-01	-0.126000	2.90e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	3.30e-01	-0.126000	3.91e-01
N-glycan antennae elongation in the medial/trans-Golgi	26	2.67e-01	-0.126000	3.29e-01
activated TAK1 mediates p38 MAPK activation	16	3.84e-01	-0.126000	4.46e-01
Translation of Structural Proteins	29	2.42e-01	-0.126000	3.00e-01
RAC3 GTPase cycle	84	4.67e-02	-0.125000	7.74e-02
Fanconi Anemia Pathway	37	1.91e-01	-0.124000	2.45e-01
Negative regulation of MET activity	20	3.39e-01	-0.123000	4.01e-01
Synthesis of PIPs at the late endosome membrane	10	5.03e-01	-0.122000	5.63e-01
FCGR3A-mediated IL10 synthesis	37	1.99e-01	-0.122000	2.54e-01
Adenylate cyclase activating pathway	10	5.04e-01	-0.122000	5.64e-01
CD209 (DC-SIGN) signaling	20	3.46e-01	-0.122000	4.07e-01
Tie2 Signaling	18	3.72e-01	-0.121000	4.35e-01
Biosynthesis of DHA-derived SPMs	17	3.88e-01	-0.121000	4.49e-01
Ion channel transport	168	6.96e-03	-0.121000	1.57e-02
Negative regulation of FGFR1 signaling	32	2.39e-01	-0.120000	2.97e-01
NOTCH2 intracellular domain regulates transcription	11	4.90e-01	-0.120000	5.51e-01
Passive transport by Aquaporins	13	4.54e-01	0.120000	5.16e-01
Interferon alpha/beta signaling	71	8.04e-02	-0.120000	1.20e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	4.06e-01	-0.120000	4.69e-01
Cell-cell junction organization	56	1.22e-01	-0.119000	1.69e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	14	4.40e-01	0.119000	5.04e-01
Diseases of hemostasis	14	4.40e-01	0.119000	5.04e-01
Peptide hormone metabolism	83	6.24e-02	-0.118000	9.76e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	4.14e-01	-0.118000	4.77e-01
Scavenging of heme from plasma	12	4.81e-01	0.117000	5.42e-01
Organic anion transporters	10	5.22e-01	-0.117000	5.82e-01
Regulation of BACH1 activity	15	4.36e-01	0.116000	5.01e-01
Cytokine Signaling in Immune system	667	3.26e-07	-0.116000	3.68e-06
Gap junction trafficking	27	3.00e-01	-0.115000	3.62e-01
Glycerophospholipid biosynthesis	114	3.35e-02	-0.115000	5.87e-02
Synthesis of bile acids and bile salts	34	2.47e-01	-0.115000	3.05e-01
RHO GTPases activate KTN1	11	5.12e-01	-0.114000	5.72e-01
Metabolism of steroids	148	1.65e-02	-0.114000	3.26e-02
Insulin receptor recycling	25	3.23e-01	-0.114000	3.85e-01
Processing and activation of SUMO	10	5.33e-01	-0.114000	5.92e-01
Gap junction trafficking and regulation	29	2.88e-01	-0.114000	3.49e-01
Leishmania infection	245	2.20e-03	-0.113000	5.96e-03
Sema3A PAK dependent Axon repulsion	14	4.63e-01	-0.113000	5.25e-01
Detoxification of Reactive Oxygen Species	35	2.53e-01	-0.111000	3.13e-01
Regulation of TP53 Activity through Acetylation	29	2.99e-01	-0.111000	3.61e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21	3.78e-01	0.111000	4.39e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	16	4.42e-01	0.111000	5.06e-01
Costimulation by the CD28 family	65	1.23e-01	-0.111000	1.70e-01
Heme degradation	16	4.45e-01	0.110000	5.08e-01
Surfactant metabolism	29	3.09e-01	0.109000	3.71e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	3.17e-01	-0.109000	3.79e-01
Cargo concentration in the ER	32	2.85e-01	-0.109000	3.46e-01
Platelet activation, signaling and aggregation	246	3.27e-03	-0.109000	8.28e-03
Peptide ligand-binding receptors	190	9.79e-03	0.109000	2.10e-02
O-linked glycosylation	107	5.27e-02	-0.108000	8.47e-02
Serotonin receptors	11	5.35e-01	-0.108000	5.93e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	5.22e-01	-0.107000	5.82e-01
Vitamin B5 (pantothenate) metabolism	16	4.61e-01	-0.106000	5.23e-01
Drug ADME	98	6.91e-02	0.106000	1.06e-01
RAS processing	19	4.24e-01	-0.106000	4.88e-01
Signaling by NODAL	22	3.90e-01	-0.106000	4.52e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	2.44e-01	-0.105000	3.02e-01
Signaling by RAS mutants	41	2.44e-01	-0.105000	3.02e-01
Signaling by moderate kinase activity BRAF mutants	41	2.44e-01	-0.105000	3.02e-01
Signaling downstream of RAS mutants	41	2.44e-01	-0.105000	3.02e-01
Methylation	14	5.02e-01	-0.104000	5.63e-01
p130Cas linkage to MAPK signaling for integrins	15	4.93e-01	-0.102000	5.54e-01
Advanced glycosylation endproduct receptor signaling	13	5.26e-01	-0.102000	5.85e-01
GPVI-mediated activation cascade	32	3.20e-01	-0.102000	3.82e-01
Interferon Signaling	194	1.51e-02	-0.101000	3.03e-02
C-type lectin receptors (CLRs)	137	4.11e-02	-0.101000	6.94e-02
Keratan sulfate/keratin metabolism	33	3.16e-01	-0.101000	3.78e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	5.47e-01	-0.100000	6.05e-01
Metalloprotease DUBs	19	4.54e-01	-0.099100	5.16e-01
Hemostasis	560	6.23e-05	-0.098700	3.10e-04
Synthesis of PE	12	5.56e-01	-0.098000	6.13e-01
RAB geranylgeranylation	57	2.03e-01	-0.097300	2.59e-01
Interleukin-4 and Interleukin-13 signaling	104	8.93e-02	-0.096400	1.31e-01
Inflammasomes	21	4.52e-01	-0.094700	5.15e-01
Pregnenolone biosynthesis	10	6.08e-01	0.093600	6.62e-01
Endogenous sterols	26	4.11e-01	-0.093000	4.74e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77	1.58e-01	-0.093000	2.09e-01
G alpha (s) signalling events	153	4.80e-02	-0.092500	7.92e-02
Endosomal Sorting Complex Required For Transport (ESCRT)	31	3.74e-01	-0.092200	4.36e-01
RHO GTPases Activate NADPH Oxidases	22	4.54e-01	0.092100	5.16e-01
HSF1-dependent transactivation	35	3.45e-01	-0.092100	4.07e-01
Metabolism of fat-soluble vitamins	46	2.83e-01	-0.091400	3.45e-01
Negative regulation of FLT3	15	5.42e-01	-0.090900	6.00e-01
Response to elevated platelet cytosolic Ca2+	121	8.56e-02	-0.090400	1.26e-01
Platelet Aggregation (Plug Formation)	37	3.43e-01	-0.090000	4.05e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	3.33e-01	0.089500	3.94e-01
APC-Cdc20 mediated degradation of Nek2A	26	4.30e-01	-0.089500	4.93e-01
Transcriptional Regulation by VENTX	41	3.24e-01	-0.088900	3.85e-01
Amine ligand-binding receptors	41	3.24e-01	-0.088900	3.85e-01
Formation of apoptosome	10	6.26e-01	-0.088900	6.78e-01
Regulation of the apoptosome activity	10	6.26e-01	-0.088900	6.78e-01
Chylomicron assembly	10	6.27e-01	0.088700	6.78e-01
Anti-inflammatory response favouring Leishmania parasite infection	164	5.04e-02	-0.088500	8.23e-02
Leishmania parasite growth and survival	164	5.04e-02	-0.088500	8.23e-02
Phosphorylation of the APC/C	20	4.97e-01	-0.087700	5.58e-01
MHC class II antigen presentation	104	1.22e-01	-0.087700	1.69e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	5.01e-01	-0.086800	5.62e-01
Signaling by RAF1 mutants	37	3.65e-01	-0.086000	4.28e-01
Platelet degranulation	116	1.10e-01	-0.085900	1.56e-01
Reproduction	82	1.78e-01	-0.085900	2.30e-01
rRNA modification in the nucleus and cytosol	55	2.73e-01	-0.085400	3.35e-01
ECM proteoglycans	55	2.74e-01	-0.085300	3.35e-01
Prolactin receptor signaling	15	5.68e-01	0.085200	6.24e-01
Signaling by EGFR in Cancer	25	4.65e-01	-0.084400	5.25e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	3.07e-01	-0.084400	3.69e-01
Regulation of localization of FOXO transcription factors	11	6.28e-01	-0.084400	6.78e-01
Pre-NOTCH Transcription and Translation	45	3.27e-01	-0.084300	3.88e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	38	3.68e-01	-0.084300	4.31e-01
Other semaphorin interactions	18	5.36e-01	-0.084300	5.93e-01
Diseases associated with visual transduction	11	6.32e-01	-0.083300	6.81e-01
Diseases of the neuronal system	11	6.32e-01	-0.083300	6.81e-01
Retinoid cycle disease events	11	6.32e-01	-0.083300	6.81e-01
Pre-NOTCH Expression and Processing	61	2.63e-01	-0.082900	3.23e-01
Diseases associated with O-glycosylation of proteins	66	2.44e-01	-0.082900	3.02e-01
Chondroitin sulfate biosynthesis	18	5.44e-01	-0.082600	6.01e-01
Cell surface interactions at the vascular wall	129	1.07e-01	0.082200	1.52e-01
Pyroptosis	26	4.69e-01	0.082000	5.30e-01
Metabolism of steroid hormones	33	4.17e-01	0.081700	4.80e-01
Regulation of IFNA/IFNB signaling	24	4.90e-01	0.081300	5.51e-01
Glycogen storage diseases	14	6.01e-01	-0.080800	6.56e-01
Termination of O-glycan biosynthesis	25	4.88e-01	0.080100	5.49e-01
Other interleukin signaling	24	4.98e-01	-0.079800	5.59e-01
SLC-mediated transmembrane transport	238	3.83e-02	-0.077900	6.53e-02
Phase II - Conjugation of compounds	109	1.62e-01	0.077500	2.13e-01
Androgen biosynthesis	11	6.58e-01	0.077100	7.03e-01
SHC1 events in ERBB2 signaling	22	5.32e-01	-0.077000	5.91e-01
TRP channels	24	5.23e-01	-0.075200	5.83e-01
Hyaluronan uptake and degradation	12	6.53e-01	-0.074900	6.99e-01
Nicotinamide salvaging	17	5.93e-01	-0.074800	6.49e-01
Striated Muscle Contraction	33	4.64e-01	0.073600	5.25e-01
Membrane binding and targetting of GAG proteins	14	6.34e-01	-0.073500	6.81e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	6.34e-01	-0.073500	6.81e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	6.23e-01	-0.073300	6.75e-01
Xenobiotics	24	5.35e-01	0.073200	5.93e-01
Phase I - Functionalization of compounds	100	2.08e-01	0.072800	2.64e-01
Beta-oxidation of very long chain fatty acids	10	6.90e-01	-0.072700	7.34e-01
Platelet Adhesion to exposed collagen	13	6.51e-01	0.072400	6.98e-01
ERBB2 Regulates Cell Motility	15	6.31e-01	-0.071700	6.81e-01
Oncogene Induced Senescence	35	4.64e-01	-0.071500	5.25e-01
Hyaluronan metabolism	17	6.11e-01	-0.071300	6.64e-01
O-linked glycosylation of mucins	62	3.32e-01	-0.071300	3.93e-01
Organic cation/anion/zwitterion transport	15	6.36e-01	0.070700	6.83e-01
Class A/1 (Rhodopsin-like receptors)	312	3.19e-02	0.070500	5.63e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	16	6.27e-01	-0.070100	6.78e-01
Scavenging by Class A Receptors	19	6.02e-01	-0.069000	6.57e-01
FGFR2b ligand binding and activation	10	7.07e-01	-0.068700	7.49e-01
Basigin interactions	24	5.65e-01	-0.067900	6.21e-01
Immune System	1877	9.93e-07	-0.067600	1.03e-05
Phenylalanine and tyrosine metabolism	10	7.11e-01	0.067600	7.53e-01
Interleukin-2 family signaling	40	4.60e-01	-0.067500	5.22e-01
CYP2E1 reactions	11	6.99e-01	0.067300	7.42e-01
Retinoid metabolism and transport	42	4.52e-01	-0.067000	5.15e-01
ADORA2B mediated anti-inflammatory cytokines production	132	1.85e-01	-0.066700	2.39e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	6.07e-01	-0.066400	6.61e-01
Chylomicron remodeling	10	7.17e-01	0.066200	7.58e-01
G-protein activation	24	5.75e-01	-0.066200	6.30e-01
Metabolism of porphyrins	27	5.54e-01	-0.065700	6.11e-01
Blood group systems biosynthesis	22	5.95e-01	0.065500	6.50e-01
RIPK1-mediated regulated necrosis	27	5.57e-01	-0.065300	6.13e-01
Regulation of necroptotic cell death	27	5.57e-01	-0.065300	6.13e-01
Thyroxine biosynthesis	10	7.23e-01	-0.064800	7.62e-01
Glucagon-type ligand receptors	33	5.20e-01	-0.064700	5.80e-01
Paracetamol ADME	30	5.42e-01	0.064400	6.00e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	6.80e-01	-0.063700	7.25e-01
Pre-NOTCH Processing in Golgi	18	6.44e-01	-0.062900	6.91e-01
Formation of Fibrin Clot (Clotting Cascade)	37	5.09e-01	0.062700	5.69e-01
Interferon gamma signaling	90	3.13e-01	-0.061500	3.75e-01
NOD1/2 Signaling Pathway	29	5.70e-01	-0.060900	6.26e-01
Acyl chain remodelling of PE	24	6.06e-01	-0.060800	6.61e-01
FCGR activation	12	7.19e-01	0.060100	7.59e-01
Degradation of the extracellular matrix	108	2.85e-01	-0.059500	3.46e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	6.65e-01	-0.058900	7.11e-01
Diseases of carbohydrate metabolism	30	5.77e-01	-0.058900	6.32e-01
Synthesis of PA	35	5.48e-01	-0.058600	6.05e-01
Biological oxidations	216	1.44e-01	0.057600	1.93e-01
GAB1 signalosome	17	6.82e-01	-0.057400	7.27e-01
Signaling by GPCR	671	1.13e-02	-0.057200	2.38e-02
Nucleotide-like (purinergic) receptors	13	7.21e-01	0.057100	7.61e-01
Activation of the phototransduction cascade	11	7.43e-01	0.057000	7.82e-01
Regulation of TP53 Activity through Methylation	18	6.77e-01	0.056700	7.23e-01
HSF1 activation	27	6.11e-01	-0.056600	6.64e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	117	2.96e-01	-0.055900	3.58e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	6.36e-01	-0.055800	6.83e-01
The phototransduction cascade	32	5.91e-01	0.054800	6.48e-01
Na+/Cl- dependent neurotransmitter transporters	18	6.87e-01	0.054800	7.32e-01
CD28 dependent Vav1 pathway	11	7.54e-01	-0.054500	7.91e-01
Tight junction interactions	28	6.19e-01	-0.054200	6.73e-01
Eicosanoid ligand-binding receptors	14	7.32e-01	-0.052800	7.72e-01
Peptide hormone biosynthesis	11	7.65e-01	-0.052100	7.99e-01
Amino acid transport across the plasma membrane	30	6.23e-01	-0.051900	6.75e-01
TNFs bind their physiological receptors	25	6.54e-01	0.051800	7.00e-01
Amyloid fiber formation	53	5.19e-01	-0.051200	5.79e-01
G alpha (q) signalling events	206	2.13e-01	-0.050200	2.69e-01
ERBB2 Activates PTK6 Signaling	13	7.55e-01	0.050000	7.91e-01
Inactivation, recovery and regulation of the phototransduction cascade	31	6.38e-01	0.048800	6.85e-01
GPCR downstream signalling	604	4.10e-02	-0.048600	6.94e-02
DAP12 interactions	40	6.00e-01	-0.047900	6.55e-01
N-Glycan antennae elongation	15	7.50e-01	-0.047500	7.87e-01
Triglyceride biosynthesis	13	7.72e-01	-0.046300	8.05e-01
NR1H2 and NR1H3-mediated signaling	53	5.65e-01	-0.045700	6.21e-01
ABC transporters in lipid homeostasis	17	7.47e-01	0.045200	7.85e-01
Regulation of innate immune responses to cytosolic DNA	14	7.70e-01	-0.045100	8.04e-01
Neutrophil degranulation	458	9.73e-02	-0.045100	1.40e-01
Binding and Uptake of Ligands by Scavenger Receptors	41	6.20e-01	0.044700	6.73e-01
Assembly of active LPL and LIPC lipase complexes	17	7.50e-01	-0.044500	7.88e-01
Gastrin-CREB signalling pathway via PKC and MAPK	17	7.60e-01	-0.042800	7.95e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	13	7.91e-01	-0.042400	8.24e-01
EGFR downregulation	30	6.89e-01	-0.042200	7.33e-01
Arachidonic acid metabolism	56	6.02e-01	-0.040300	6.57e-01
Metabolic disorders of biological oxidation enzymes	32	6.99e-01	-0.039500	7.42e-01
Post-chaperonin tubulin folding pathway	23	7.44e-01	-0.039400	7.82e-01
Downregulation of ERBB2 signaling	28	7.21e-01	-0.039000	7.61e-01
Collagen degradation	39	6.88e-01	-0.037200	7.32e-01
Carboxyterminal post-translational modifications of tubulin	40	6.86e-01	0.036900	7.31e-01
LGI-ADAM interactions	14	8.13e-01	-0.036400	8.45e-01
Spry regulation of FGF signaling	16	8.03e-01	-0.036100	8.34e-01
Free fatty acids regulate insulin secretion	10	8.46e-01	0.035400	8.74e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	7.60e-01	-0.035200	7.95e-01
Interleukin-2 signaling	11	8.42e-01	-0.034600	8.72e-01
Alpha-protein kinase 1 signaling pathway	10	8.52e-01	-0.034100	8.78e-01
TRAF6 mediated IRF7 activation	28	7.55e-01	-0.034000	7.91e-01
Phase 4 - resting membrane potential	19	8.00e-01	-0.033500	8.32e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	43	7.10e-01	-0.032800	7.52e-01
CASP8 activity is inhibited	11	8.53e-01	0.032200	8.78e-01
Dimerization of procaspase-8	11	8.53e-01	0.032200	8.78e-01
Regulation by c-FLIP	11	8.53e-01	0.032200	8.78e-01
Bile acid and bile salt metabolism	45	7.09e-01	-0.032100	7.51e-01
Signaling by high-kinase activity BRAF mutants	32	7.58e-01	-0.031400	7.94e-01
Metallothioneins bind metals	11	8.65e-01	0.029700	8.87e-01
Innate Immune System	999	1.21e-01	-0.028900	1.68e-01
Lewis blood group biosynthesis	18	8.32e-01	0.028900	8.63e-01
Acyl chain remodelling of PI	16	8.43e-01	-0.028500	8.72e-01
GRB2 events in EGFR signaling	13	8.60e-01	0.028300	8.83e-01
Keratan sulfate degradation	12	8.67e-01	0.028000	8.88e-01
GRB2 events in ERBB2 signaling	16	8.50e-01	-0.027300	8.77e-01
Gap junction assembly	18	8.45e-01	0.026700	8.73e-01
Glutathione conjugation	37	7.84e-01	0.026000	8.17e-01
G alpha (i) signalling events	306	4.50e-01	-0.025100	5.14e-01
Cytochrome P450 - arranged by substrate type	64	7.40e-01	0.024000	7.79e-01
SHC1 events in EGFR signaling	14	8.79e-01	-0.023500	8.99e-01
Synthesis of PIPs at the Golgi membrane	17	8.70e-01	0.023000	8.91e-01
Cytosolic sulfonation of small molecules	23	8.49e-01	-0.022900	8.77e-01
Keratan sulfate biosynthesis	28	8.37e-01	-0.022500	8.67e-01
Plasma lipoprotein assembly	19	8.67e-01	-0.022200	8.88e-01
Plasma lipoprotein remodeling	32	8.29e-01	-0.022100	8.60e-01
Intrinsic Pathway of Fibrin Clot Formation	21	8.62e-01	0.022000	8.85e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	8.87e-01	-0.021200	9.06e-01
Attenuation phase	25	8.58e-01	-0.020700	8.82e-01
GPCR ligand binding	444	4.79e-01	0.019600	5.40e-01
Chaperone Mediated Autophagy	19	8.87e-01	0.018800	9.06e-01
Transport of bile salts and organic acids, metal ions and amine compounds	84	7.73e-01	-0.018200	8.05e-01
Acyl chain remodelling of PC	26	8.77e-01	-0.017600	8.97e-01
Cell recruitment (pro-inflammatory response)	25	8.89e-01	0.016100	9.07e-01
Purinergic signaling in leishmaniasis infection	25	8.89e-01	0.016100	9.07e-01
Mucopolysaccharidoses	10	9.31e-01	-0.015900	9.40e-01
Aflatoxin activation and detoxification	20	9.05e-01	-0.015400	9.20e-01
The canonical retinoid cycle in rods (twilight vision)	23	9.01e-01	0.015000	9.16e-01
PIWI-interacting RNA (piRNA) biogenesis	29	8.90e-01	-0.014800	9.07e-01
Tandem pore domain potassium channels	12	9.30e-01	-0.014700	9.40e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	9.23e-01	-0.014300	9.35e-01
Post-translational modification: synthesis of GPI-anchored proteins	90	8.19e-01	-0.014000	8.50e-01
Diseases associated with the TLR signaling cascade	29	8.99e-01	0.013600	9.15e-01
Diseases of Immune System	29	8.99e-01	0.013600	9.15e-01
Acyl chain remodelling of PS	21	9.14e-01	0.013600	9.27e-01
Cellular hexose transport	21	9.22e-01	0.012400	9.34e-01
Response to metal ions	14	9.37e-01	0.012100	9.47e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	9.38e-01	0.012000	9.47e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	31	9.13e-01	0.011300	9.27e-01
Late endosomal microautophagy	32	9.13e-01	0.011200	9.27e-01
RA biosynthesis pathway	22	9.45e-01	-0.008490	9.53e-01
Thrombin signalling through proteinase activated receptors (PARs)	32	9.40e-01	-0.007750	9.48e-01
Regulated Necrosis	53	9.30e-01	0.006980	9.40e-01
Visual phototransduction	93	9.16e-01	0.006300	9.29e-01
Nicotinate metabolism	29	9.58e-01	0.005680	9.65e-01
Caspase activation via Death Receptors in the presence of ligand	16	9.71e-01	0.005260	9.76e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	10	9.78e-01	-0.005030	9.83e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	9.70e-01	0.004470	9.76e-01
Interleukin-20 family signaling	25	9.70e-01	0.004290	9.76e-01
Glyoxylate metabolism and glycine degradation	30	9.83e-01	0.002190	9.87e-01
ROS and RNS production in phagocytes	35	9.86e-01	0.001710	9.89e-01
Metabolism of amine-derived hormones	17	9.91e-01	0.001660	9.93e-01
Pyrimidine salvage	10	9.96e-01	-0.000903	9.97e-01
MAP2K and MAPK activation	36	9.94e-01	-0.000723	9.96e-01
Acyl chain remodelling of PG	18	9.96e-01	0.000668	9.97e-01
Transport of vitamins, nucleosides, and related molecules	38	9.98e-01	0.000179	9.98e-01

---

Detailed Gene set reports

Folding of actin by CCT/TriC

Folding of actin by CCT/TriC

	441
set	Folding of actin by CCT/TriC
setSize	10
pANOVA	0.000212
s.dist	-0.676
p.adjustANOVA	0.000852

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACTB	-21952.5
CCT7	-21406.5
CCT6A	-20888.5
CCT8	-20835.5
CCT6B	-18632.5
TCP1	-16726.5
CCT4	-16427.5
CCT5	-15859.5
CCT2	-14332.5
CCT3	-11795.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACTB	-21952.5
CCT7	-21406.5
CCT6A	-20888.5
CCT8	-20835.5
CCT6B	-18632.5
TCP1	-16726.5
CCT4	-16427.5
CCT5	-15859.5
CCT2	-14332.5
CCT3	-11795.5

---

FOXO-mediated transcription of cell cycle genes

FOXO-mediated transcription of cell cycle genes

	426
set	FOXO-mediated transcription of cell cycle genes
setSize	16
pANOVA	1.18e-05
s.dist	-0.632
p.adjustANOVA	8.23e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BTG1	-21718.5
KLF4	-21404.5
SMAD4	-20586.5
FOXO3	-19624.5
CAV1	-19555.5
FOXG1	-19268.5
CDKN1B	-19220.5
PCBP4	-18630.5
SMAD2	-17580.5
RBL2	-17219.5
CCNG2	-16510.5
MSTN	-15995.5
GADD45A	-15001.5
CDKN1A	-14105.5
SMAD3	-13045.5
FOXO1	-7497.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BTG1	-21718.5
KLF4	-21404.5
SMAD4	-20586.5
FOXO3	-19624.5
CAV1	-19555.5
FOXG1	-19268.5
CDKN1B	-19220.5
PCBP4	-18630.5
SMAD2	-17580.5
RBL2	-17219.5
CCNG2	-16510.5
MSTN	-15995.5
GADD45A	-15001.5
CDKN1A	-14105.5
SMAD3	-13045.5
FOXO1	-7497.5

---

NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus

	781
set	NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize	11
pANOVA	6e-04
s.dist	-0.597
p.adjustANOVA	0.00199

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NOTCH4	-21359.5
NCSTN	-20839.5
JAG1	-19940.5
ADAM10	-19689.5
DLL4	-19060.5
PSENEN	-18441.5
PSEN1	-18288.5
PSEN2	-17761.5
YWHAZ	-17474.5
APH1B	-6959.5
APH1A	-5574.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NOTCH4	-21359.5
NCSTN	-20839.5
JAG1	-19940.5
ADAM10	-19689.5
DLL4	-19060.5
PSENEN	-18441.5
PSEN1	-18288.5
PSEN2	-17761.5
YWHAZ	-17474.5
APH1B	-6959.5
APH1A	-5574.5

---

Repression of WNT target genes

Repression of WNT target genes

	1124
set	Repression of WNT target genes
setSize	13
pANOVA	0.00032
s.dist	-0.576
p.adjustANOVA	0.0012

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TCF7	-22074.5
AXIN2	-20162.5
MYC	-19668.5
TLE1	-18877.5
CTBP2	-18822.5
TLE3	-18435.5
TLE4	-18212.5
LEF1	-18002.5
TCF7L1	-16813.5
TLE2	-13046.5
HDAC1	-12954.5
TCF7L2	-12880.5
CTBP1	-5544.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TCF7	-22074.5
AXIN2	-20162.5
MYC	-19668.5
TLE1	-18877.5
CTBP2	-18822.5
TLE3	-18435.5
TLE4	-18212.5
LEF1	-18002.5
TCF7L1	-16813.5
TLE2	-13046.5
HDAC1	-12954.5
TCF7L2	-12880.5
CTBP1	-5544.5

---

Crosslinking of collagen fibrils

Crosslinking of collagen fibrils

	243
set	Crosslinking of collagen fibrils
setSize	10
pANOVA	0.00215
s.dist	-0.56
p.adjustANOVA	0.00589

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LOXL3	-21905.5
TLL1	-21683.5
TLL2	-21277.5
PCOLCE	-18008.5
LOX	-17263.5
LOXL1	-16120.5
PXDN	-15419.5
LOXL2	-12814.5
LOXL4	-12576.5
BMP1	-6631.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LOXL3	-21905.5
TLL1	-21683.5
TLL2	-21277.5
PCOLCE	-18008.5
LOX	-17263.5
LOXL1	-16120.5
PXDN	-15419.5
LOXL2	-12814.5
LOXL4	-12576.5
BMP1	-6631.5

---

Processing of Intronless Pre-mRNAs

Processing of Intronless Pre-mRNAs

	955
set	Processing of Intronless Pre-mRNAs
setSize	19
pANOVA	2.36e-05
s.dist	-0.56
p.adjustANOVA	0.000141

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-21980.5
PAPOLA	-21384.5
FIP1L1	-21233.5
CPSF3	-20988.5
CPSF2	-20751.5
CPSF4	-20320.5
CLP1	-20138.5
CSTF1	-19976.5
WDR33	-19593.5
NCBP2	-18428.5
NUDT21	-18270.5
CSTF3	-16705.5
SYMPK	-16007.5
PCF11	-15073.5
CPSF7	-12935.5
CPSF6	-12106.5
CPSF1	-9582.5
CSTF2T	-7070.5
PABPN1	1646.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-21980.5
PAPOLA	-21384.5
FIP1L1	-21233.5
CPSF3	-20988.5
CPSF2	-20751.5
CPSF4	-20320.5
CLP1	-20138.5
CSTF1	-19976.5
WDR33	-19593.5
NCBP2	-18428.5
NUDT21	-18270.5
CSTF3	-16705.5
SYMPK	-16007.5
PCF11	-15073.5
CPSF7	-12935.5
CPSF6	-12106.5
CPSF1	-9582.5
CSTF2T	-7070.5
PABPN1	1646.5

---

Disorders of Developmental Biology

Disorders of Developmental Biology

	339
set	Disorders of Developmental Biology
setSize	11
pANOVA	0.00204
s.dist	-0.537
p.adjustANOVA	0.00565

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SIN3A	-20791.5
CAMK4	-20762.5
BDNF	-19343.5
CALM1	-19082.5
HDAC3	-17766.5
TBL1XR1	-17032.5
GPS2	-16994.5
PRKACA	-16613.5
NCOR1	-13722.5
HDAC1	-12954.5
NCOR2	-1658.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SIN3A	-20791.5
CAMK4	-20762.5
BDNF	-19343.5
CALM1	-19082.5
HDAC3	-17766.5
TBL1XR1	-17032.5
GPS2	-16994.5
PRKACA	-16613.5
NCOR1	-13722.5
HDAC1	-12954.5
NCOR2	-1658.5

---

Disorders of Nervous System Development

Disorders of Nervous System Development

	340
set	Disorders of Nervous System Development
setSize	11
pANOVA	0.00204
s.dist	-0.537
p.adjustANOVA	0.00565

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SIN3A	-20791.5
CAMK4	-20762.5
BDNF	-19343.5
CALM1	-19082.5
HDAC3	-17766.5
TBL1XR1	-17032.5
GPS2	-16994.5
PRKACA	-16613.5
NCOR1	-13722.5
HDAC1	-12954.5
NCOR2	-1658.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SIN3A	-20791.5
CAMK4	-20762.5
BDNF	-19343.5
CALM1	-19082.5
HDAC3	-17766.5
TBL1XR1	-17032.5
GPS2	-16994.5
PRKACA	-16613.5
NCOR1	-13722.5
HDAC1	-12954.5
NCOR2	-1658.5

---

Loss of function of MECP2 in Rett syndrome

Loss of function of MECP2 in Rett syndrome

	676
set	Loss of function of MECP2 in Rett syndrome
setSize	11
pANOVA	0.00204
s.dist	-0.537
p.adjustANOVA	0.00565

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SIN3A	-20791.5
CAMK4	-20762.5
BDNF	-19343.5
CALM1	-19082.5
HDAC3	-17766.5
TBL1XR1	-17032.5
GPS2	-16994.5
PRKACA	-16613.5
NCOR1	-13722.5
HDAC1	-12954.5
NCOR2	-1658.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SIN3A	-20791.5
CAMK4	-20762.5
BDNF	-19343.5
CALM1	-19082.5
HDAC3	-17766.5
TBL1XR1	-17032.5
GPS2	-16994.5
PRKACA	-16613.5
NCOR1	-13722.5
HDAC1	-12954.5
NCOR2	-1658.5

---

Pervasive developmental disorders

Pervasive developmental disorders

	902
set	Pervasive developmental disorders
setSize	11
pANOVA	0.00204
s.dist	-0.537
p.adjustANOVA	0.00565

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SIN3A	-20791.5
CAMK4	-20762.5
BDNF	-19343.5
CALM1	-19082.5
HDAC3	-17766.5
TBL1XR1	-17032.5
GPS2	-16994.5
PRKACA	-16613.5
NCOR1	-13722.5
HDAC1	-12954.5
NCOR2	-1658.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SIN3A	-20791.5
CAMK4	-20762.5
BDNF	-19343.5
CALM1	-19082.5
HDAC3	-17766.5
TBL1XR1	-17032.5
GPS2	-16994.5
PRKACA	-16613.5
NCOR1	-13722.5
HDAC1	-12954.5
NCOR2	-1658.5

---

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

	884
set	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
setSize	10
pANOVA	0.00331
s.dist	-0.536
p.adjustANOVA	0.00835

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GSC	-21580.5
GATA6	-20885.5
CDX2	-20629.5
SOX2	-17376.5
EOMES	-17246.5
TSC22D1	-16794.5
DKK1	-14601.5
NANOG	-10973.5
POU5F1	-10570.5
HHEX	-9901.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GSC	-21580.5
GATA6	-20885.5
CDX2	-20629.5
SOX2	-17376.5
EOMES	-17246.5
TSC22D1	-16794.5
DKK1	-14601.5
NANOG	-10973.5
POU5F1	-10570.5
HHEX	-9901.5

---

Transcriptional regulation of testis differentiation

Transcriptional regulation of testis differentiation

	1426
set	Transcriptional regulation of testis differentiation
setSize	12
pANOVA	0.00152
s.dist	-0.529
p.adjustANOVA	0.00447

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FOXL2	-22097.5
WT1	-21974.5
GATA4	-21358.5
FGF9	-19688.5
SOX9	-19384.5
DHH	-19175.5
ZFPM2	-16001.5
AMH	-15831.5
PTGDS	-11740.5
DMRT1	-10832.5
WNT4	-10808.5
NR5A1	-2564.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FOXL2	-22097.5
WT1	-21974.5
GATA4	-21358.5
FGF9	-19688.5
SOX9	-19384.5
DHH	-19175.5
ZFPM2	-16001.5
AMH	-15831.5
PTGDS	-11740.5
DMRT1	-10832.5
WNT4	-10808.5
NR5A1	-2564.5

---

Beta defensins

Beta defensins

	117
set	Beta defensins
setSize	32
pANOVA	2.31e-07
s.dist	0.528
p.adjustANOVA	2.7e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DEFB123	3904.5
DEFB118	3684.5
DEFB133	3577.5
DEFB125	3572.5
DEFB119	3366.5
DEFB107A	3338.0
TLR1	3265.5
DEFB108B	3259.5
CCR2	3178.5
DEFB1	0.5
DEFB105A	0.5
DEFB103A	0.5
DEFB110	0.5
DEFB132	-1109.5
DEFB131	-1481.5
DEFB127	-1528.5
CCR6	-1547.5
DEFB135	-1567.5
DEFB124	-1714.5
DEFB115	-2207.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DEFB123	3904.5
DEFB118	3684.5
DEFB133	3577.5
DEFB125	3572.5
DEFB119	3366.5
DEFB107A	3338.0
TLR1	3265.5
DEFB108B	3259.5
CCR2	3178.5
DEFB1	0.5
DEFB105A	0.5
DEFB103A	0.5
DEFB110	0.5
DEFB132	-1109.5
DEFB131	-1481.5
DEFB127	-1528.5
CCR6	-1547.5
DEFB135	-1567.5
DEFB124	-1714.5
DEFB115	-2207.5
DEFB116	-2448.5
DEFB121	-3234.5
DEFB128	-4019.5
DEFB126	-5150.5
DEFB113	-6447.5
DEFB114	-7523.5
DEFB106A	-7838.0
DEFB136	-8037.5
DEFB134	-8491.5
DEFB104A	-8764.0
DEFB129	-9184.5
TLR2	-17767.5

---

Regulated proteolysis of p75NTR

Regulated proteolysis of p75NTR

	1069
set	Regulated proteolysis of p75NTR
setSize	11
pANOVA	0.0025
s.dist	-0.526
p.adjustANOVA	0.00665

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRAF6	-21294.5
ADAM17	-21224.5
NCSTN	-20839.5
PSENEN	-18441.5
PSEN1	-18288.5
PSEN2	-17761.5
NFKB1	-16140.5
NGFR	-14853.5
RELA	-13808.5
APH1B	-6959.5
APH1A	-5574.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRAF6	-21294.5
ADAM17	-21224.5
NCSTN	-20839.5
PSENEN	-18441.5
PSEN1	-18288.5
PSEN2	-17761.5
NFKB1	-16140.5
NGFR	-14853.5
RELA	-13808.5
APH1B	-6959.5
APH1A	-5574.5

---

Diseases associated with glycosylation precursor biosynthesis

Diseases associated with glycosylation precursor biosynthesis

	325
set	Diseases associated with glycosylation precursor biosynthesis
setSize	15
pANOVA	0.000433
s.dist	-0.525
p.adjustANOVA	0.00153

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PGM1	-21936.5
GALE	-21873.5
DOLK	-20285.5
DPM3	-20160.5
SRD5A3	-19374.5
GFPT1	-18453.5
MPI	-18324.5
GALK1	-18190.5
GNE	-17746.5
DPM1	-17482.5
DHDDS	-16076.5
NUS1	-12517.5
PMM2	-9496.5
GALT	-4110.5
DPM2	-2510.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PGM1	-21936.5
GALE	-21873.5
DOLK	-20285.5
DPM3	-20160.5
SRD5A3	-19374.5
GFPT1	-18453.5
MPI	-18324.5
GALK1	-18190.5
GNE	-17746.5
DPM1	-17482.5
DHDDS	-16076.5
NUS1	-12517.5
PMM2	-9496.5
GALT	-4110.5
DPM2	-2510.5

---

Processing of Capped Intronless Pre-mRNA

Processing of Capped Intronless Pre-mRNA

	953
set	Processing of Capped Intronless Pre-mRNA
setSize	28
pANOVA	1.57e-06
s.dist	-0.524
p.adjustANOVA	1.59e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-21980.5
PAPOLA	-21384.5
LSM11	-21355.5
FIP1L1	-21233.5
CPSF3	-20988.5
CPSF2	-20751.5
LSM10	-20335.5
CPSF4	-20320.5
CLP1	-20138.5
CSTF1	-19976.5
SLBP	-19880.5
WDR33	-19593.5
SNRPD3	-19465.5
SNRPG	-19279.5
NCBP2	-18428.5
NUDT21	-18270.5
CSTF3	-16705.5
SNRPF	-16209.5
SYMPK	-16007.5
PCF11	-15073.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-21980.5
PAPOLA	-21384.5
LSM11	-21355.5
FIP1L1	-21233.5
CPSF3	-20988.5
CPSF2	-20751.5
LSM10	-20335.5
CPSF4	-20320.5
CLP1	-20138.5
CSTF1	-19976.5
SLBP	-19880.5
WDR33	-19593.5
SNRPD3	-19465.5
SNRPG	-19279.5
NCBP2	-18428.5
NUDT21	-18270.5
CSTF3	-16705.5
SNRPF	-16209.5
SYMPK	-16007.5
PCF11	-15073.5
CPSF7	-12935.5
CPSF6	-12106.5
ZNF473	-12032.5
CPSF1	-9582.5
CSTF2T	-7070.5
SNRPE	-3211.5
SNRPB	-2288.5
PABPN1	1646.5

---

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

	1364
set	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
setSize	14
pANOVA	7e-04
s.dist	-0.523
p.adjustANOVA	0.00225

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCNE1	-21436.5
CCNA1	-21140.5
E2F8	-20938.5
E2F1	-19632.5
CDKN1B	-19220.5
CCNA2	-19061.5
PCBP4	-18630.5
CDK2	-16367.5
E2F7	-15412.5
CDKN1A	-14105.5
CCNE2	-11345.5
ZNF385A	-11096.5
TP53	-8022.5
ARID3A	-5938.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCNE1	-21436.5
CCNA1	-21140.5
E2F8	-20938.5
E2F1	-19632.5
CDKN1B	-19220.5
CCNA2	-19061.5
PCBP4	-18630.5
CDK2	-16367.5
E2F7	-15412.5
CDKN1A	-14105.5
CCNE2	-11345.5
ZNF385A	-11096.5
TP53	-8022.5
ARID3A	-5938.5

---

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

	1167
set	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize	11
pANOVA	0.00275
s.dist	-0.521
p.adjustANOVA	0.00722

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-21980.5
LSM11	-21355.5
LSM10	-20335.5
SLBP	-19880.5
SNRPD3	-19465.5
SNRPG	-19279.5
NCBP2	-18428.5
SNRPF	-16209.5
ZNF473	-12032.5
SNRPE	-3211.5
SNRPB	-2288.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-21980.5
LSM11	-21355.5
LSM10	-20335.5
SLBP	-19880.5
SNRPD3	-19465.5
SNRPG	-19279.5
NCBP2	-18428.5
SNRPF	-16209.5
ZNF473	-12032.5
SNRPE	-3211.5
SNRPB	-2288.5

---

Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade

	119
set	Beta-catenin phosphorylation cascade
setSize	16
pANOVA	0.00033
s.dist	-0.518
p.adjustANOVA	0.00123

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
FRAT2	-19999.5
FRAT1	-19954.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
FRAT2	-19999.5
FRAT1	-19954.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

Defensins

Defensins

	299
set	Defensins
setSize	40
pANOVA	1.96e-08
s.dist	0.513
p.adjustANOVA	2.98e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DEFB123	3904.5
DEFA1	3897.0
DEFB118	3684.5
DEFA3	3618.5
DEFB133	3577.5
DEFB125	3572.5
DEFB119	3366.5
DEFB107A	3338.0
TLR1	3265.5
DEFB108B	3259.5
CCR2	3178.5
DEFA4	1631.5
DEFB1	0.5
DEFB105A	0.5
DEFB103A	0.5
DEFB110	0.5
DEFB132	-1109.5
DEFB131	-1481.5
DEFB127	-1528.5
CCR6	-1547.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DEFB123	3904.5
DEFA1	3897.0
DEFB118	3684.5
DEFA3	3618.5
DEFB133	3577.5
DEFB125	3572.5
DEFB119	3366.5
DEFB107A	3338.0
TLR1	3265.5
DEFB108B	3259.5
CCR2	3178.5
DEFA4	1631.5
DEFB1	0.5
DEFB105A	0.5
DEFB103A	0.5
DEFB110	0.5
DEFB132	-1109.5
DEFB131	-1481.5
DEFB127	-1528.5
CCR6	-1547.5
DEFB135	-1567.5
DEFB124	-1714.5
DEFB115	-2207.5
DEFB116	-2448.5
PRSS3	-2915.5
DEFA6	-3030.5
DEFB121	-3234.5
DEFB128	-4019.5
DEFB126	-5150.5
DEFB113	-6447.5
CD4	-6767.5
DEFB114	-7523.5
DEFB106A	-7838.0
DEFB136	-8037.5
DEFB134	-8491.5
DEFB104A	-8764.0
DEFA5	-9006.5
DEFB129	-9184.5
ART1	-12699.5
TLR2	-17767.5

---

Physiological factors

Physiological factors

	917
set	Physiological factors
setSize	12
pANOVA	0.00249
s.dist	-0.504
p.adjustANOVA	0.00664

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NKX2-5	-21746.5
TBX5	-21422.5
GATA4	-21358.5
WWTR1	-20496.5
NPPA	-20069.5
NPR1	-19685.5
NPPC	-17475.5
CORIN	-17396.5
KAT2B	-10519.5
HIPK2	-9029.5
NPR2	-6668.5
HIPK1	-1764.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NKX2-5	-21746.5
TBX5	-21422.5
GATA4	-21358.5
WWTR1	-20496.5
NPPA	-20069.5
NPR1	-19685.5
NPPC	-17475.5
CORIN	-17396.5
KAT2B	-10519.5
HIPK2	-9029.5
NPR2	-6668.5
HIPK1	-1764.5

---

SLBP independent Processing of Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs

	1168
set	SLBP independent Processing of Histone Pre-mRNAs
setSize	10
pANOVA	0.00721
s.dist	-0.491
p.adjustANOVA	0.0162

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP1	-21980.5
LSM11	-21355.5
LSM10	-20335.5
SNRPD3	-19465.5
SNRPG	-19279.5
NCBP2	-18428.5
SNRPF	-16209.5
ZNF473	-12032.5
SNRPE	-3211.5
SNRPB	-2288.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP1	-21980.5
LSM11	-21355.5
LSM10	-20335.5
SNRPD3	-19465.5
SNRPG	-19279.5
NCBP2	-18428.5
SNRPF	-16209.5
ZNF473	-12032.5
SNRPE	-3211.5
SNRPB	-2288.5

---

Signaling by FGFR2 IIIa TM

Signaling by FGFR2 IIIa TM

	1240
set	Signaling by FGFR2 IIIa TM
setSize	19
pANOVA	0.000214
s.dist	-0.49
p.adjustANOVA	0.000852

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2D	-22060.5
NCBP1	-21980.5
GTF2F1	-21038.5
POLR2L	-21029.5
POLR2A	-20617.5
POLR2F	-19650.5
POLR2C	-19178.5
POLR2I	-19009.5
NCBP2	-18428.5
FGFR2	-17537.5
POLR2G	-17424.5
GTF2F2	-16893.5
POLR2B	-16136.5
FGF1	-15290.5
POLR2H	-12642.5
FGF2	-6956.5
POLR2E	-6942.5
POLR2J	-2815.5
POLR2K	2010.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2D	-22060.5
NCBP1	-21980.5
GTF2F1	-21038.5
POLR2L	-21029.5
POLR2A	-20617.5
POLR2F	-19650.5
POLR2C	-19178.5
POLR2I	-19009.5
NCBP2	-18428.5
FGFR2	-17537.5
POLR2G	-17424.5
GTF2F2	-16893.5
POLR2B	-16136.5
FGF1	-15290.5
POLR2H	-12642.5
FGF2	-6956.5
POLR2E	-6942.5
POLR2J	-2815.5
POLR2K	2010.5

---

Signaling by PDGFRA extracellular domain mutants

Signaling by PDGFRA extracellular domain mutants

	1276
set	Signaling by PDGFRA extracellular domain mutants
setSize	12
pANOVA	0.004
s.dist	-0.48
p.adjustANOVA	0.00979

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KRAS	-21833.5
PIK3CB	-21815.5
PIK3CA	-20323.5
GRB2	-19995.5
PDGFRA	-19525.5
STAT1	-17869.5
STAT3	-15518.5
PIK3R2	-14009.5
PIK3R1	-13634.5
SOS1	-10230.5
HRAS	-7215.5
NRAS	-1825.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KRAS	-21833.5
PIK3CB	-21815.5
PIK3CA	-20323.5
GRB2	-19995.5
PDGFRA	-19525.5
STAT1	-17869.5
STAT3	-15518.5
PIK3R2	-14009.5
PIK3R1	-13634.5
SOS1	-10230.5
HRAS	-7215.5
NRAS	-1825.5

---

Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants

Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants

	1277
set	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
setSize	12
pANOVA	0.004
s.dist	-0.48
p.adjustANOVA	0.00979

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KRAS	-21833.5
PIK3CB	-21815.5
PIK3CA	-20323.5
GRB2	-19995.5
PDGFRA	-19525.5
STAT1	-17869.5
STAT3	-15518.5
PIK3R2	-14009.5
PIK3R1	-13634.5
SOS1	-10230.5
HRAS	-7215.5
NRAS	-1825.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KRAS	-21833.5
PIK3CB	-21815.5
PIK3CA	-20323.5
GRB2	-19995.5
PDGFRA	-19525.5
STAT1	-17869.5
STAT3	-15518.5
PIK3R2	-14009.5
PIK3R1	-13634.5
SOS1	-10230.5
HRAS	-7215.5
NRAS	-1825.5

---

MET receptor recycling

MET receptor recycling

	695
set	MET receptor recycling
setSize	10
pANOVA	0.00946
s.dist	-0.474
p.adjustANOVA	0.0205

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ARF6	-21769.5
GRB2	-19995.5
MET	-19397.5
GGA3	-17472.5
CRKL	-17305.5
GAB1	-17270.5
RAB4A	-17100.5
CRK	-14328.5
RAB4B	-5573.5
HGF	-2176.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ARF6	-21769.5
GRB2	-19995.5
MET	-19397.5
GGA3	-17472.5
CRKL	-17305.5
GAB1	-17270.5
RAB4A	-17100.5
CRK	-14328.5
RAB4B	-5573.5
HGF	-2176.5

---

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

	1488
set	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
setSize	13
pANOVA	0.00313
s.dist	-0.473
p.adjustANOVA	0.00803

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FZD2	-20397.5
CLTC	-18977.5
WNT5A	-18860.5
ROR1	-18603.5
CLTB	-17987.5
AP2B1	-16861.5
CLTA	-15443.5
ROR2	-15124.5
FZD5	-14696.5
AP2M1	-13420.5
AP2S1	-13057.5
AP2A1	-11961.5
AP2A2	-2607.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FZD2	-20397.5
CLTC	-18977.5
WNT5A	-18860.5
ROR1	-18603.5
CLTB	-17987.5
AP2B1	-16861.5
CLTA	-15443.5
ROR2	-15124.5
FZD5	-14696.5
AP2M1	-13420.5
AP2S1	-13057.5
AP2A1	-11961.5
AP2A2	-2607.5

---

CTNNB1 S33 mutants aren’t phosphorylated

CTNNB1 S33 mutants aren’t phosphorylated

	153
set	CTNNB1 S33 mutants aren’t phosphorylated
setSize	14
pANOVA	0.00219
s.dist	-0.473
p.adjustANOVA	0.00594

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

CTNNB1 S37 mutants aren’t phosphorylated

CTNNB1 S37 mutants aren’t phosphorylated

	154
set	CTNNB1 S37 mutants aren’t phosphorylated
setSize	14
pANOVA	0.00219
s.dist	-0.473
p.adjustANOVA	0.00594

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

CTNNB1 S45 mutants aren’t phosphorylated

CTNNB1 S45 mutants aren’t phosphorylated

	155
set	CTNNB1 S45 mutants aren’t phosphorylated
setSize	14
pANOVA	0.00219
s.dist	-0.473
p.adjustANOVA	0.00594

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

CTNNB1 T41 mutants aren’t phosphorylated

CTNNB1 T41 mutants aren’t phosphorylated

	156
set	CTNNB1 T41 mutants aren’t phosphorylated
setSize	14
pANOVA	0.00219
s.dist	-0.473
p.adjustANOVA	0.00594

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

Signaling by CTNNB1 phospho-site mutants

Signaling by CTNNB1 phospho-site mutants

	1224
set	Signaling by CTNNB1 phospho-site mutants
setSize	14
pANOVA	0.00219
s.dist	-0.473
p.adjustANOVA	0.00594

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

Signaling by GSK3beta mutants

Signaling by GSK3beta mutants

	1249
set	Signaling by GSK3beta mutants
setSize	14
pANOVA	0.00219
s.dist	-0.473
p.adjustANOVA	0.00594

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CTNNB1	-18143.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

Antimicrobial peptides

Antimicrobial peptides

	85
set	Antimicrobial peptides
setSize	82
pANOVA	3.37e-13
s.dist	0.464
p.adjustANOVA	1.01e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DEFB123	3904.5
DEFA1	3897.0
LYZ	3836.5
DEFB118	3684.5
DEFA3	3618.5
HTN1	3587.5
DEFB133	3577.5
DEFB125	3572.5
PRTN3	3486.5
DEFB119	3366.5
RNASE7	3351.5
DEFB107A	3338.0
TLR1	3265.5
DEFB108B	3259.5
CTSG	3211.5
CCR2	3178.5
PI3	3162.5
BPIFB6	3112.5
ELANE	2540.5
S100A9	2428.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DEFB123	3904.5
DEFA1	3897.0
LYZ	3836.5
DEFB118	3684.5
DEFA3	3618.5
HTN1	3587.5
DEFB133	3577.5
DEFB125	3572.5
PRTN3	3486.5
DEFB119	3366.5
RNASE7	3351.5
DEFB107A	3338.0
TLR1	3265.5
DEFB108B	3259.5
CTSG	3211.5
CCR2	3178.5
PI3	3162.5
BPIFB6	3112.5
ELANE	2540.5
S100A9	2428.5
REG3G	2364.5
PLA2G2A	1976.5
BPI	1701.5
DEFA4	1631.5
DCD	1378.5
BPIFA2	0.5
SEMG1	0.5
S100A8	0.5
BPIFA1	0.5
GNLY	0.5
DEFB1	0.5
DEFB105A	0.5
DEFB103A	0.5
RNASE3	0.5
LCN2	0.5
DEFB110	0.5
DEFB132	-1109.5
SLC11A1	-1303.5
DEFB131	-1481.5
DEFB127	-1528.5
CCR6	-1547.5
DEFB135	-1567.5
DEFB124	-1714.5
ITLN1	-1797.5
BPIFB4	-1810.5
CAMP	-2043.5
DEFB115	-2207.5
S100A7A	-2400.5
DEFB116	-2448.5
REG3A	-2713.5
PRSS3	-2915.5
DEFA6	-3030.5
DEFB121	-3234.5
PGLYRP2	-3295.5
DEFB128	-4019.5
RNASE6	-4266.5
DEFB126	-5150.5
EPPIN	-5322.5
PGLYRP4	-5675.5
DEFB113	-6447.5
S100A7	-6490.5
CD4	-6767.5
RNASE8	-6848.5
PGLYRP3	-7254.5
DEFB114	-7523.5
DEFB106A	-7838.0
DEFB136	-8037.5
DEFB134	-8491.5
BPIFB2	-8740.5
DEFB104A	-8764.0
DEFA5	-9006.5
DEFB129	-9184.5
BPIFB1	-9296.5
HTN3	-11424.5
ART1	-12699.5
CLU	-14608.5
ATOX1	-16699.5
TLR2	-17767.5
LTF	-18268.5
LEAP2	-18403.5
CHGA	-19032.5
PGLYRP1	-19820.5

---

RAF-independent MAPK1/3 activation

RAF-independent MAPK1/3 activation

	984
set	RAF-independent MAPK1/3 activation
setSize	22
pANOVA	0.000165
s.dist	-0.464
p.adjustANOVA	0.000683

Top enriched genes

Top 20 genes

GeneID	Gene Rank
JAK1	-21183.5
DUSP6	-20489.5
DUSP4	-20217.5
DUSP16	-20055.5
DUSP2	-19867.5
DUSP1	-19414.5
DUSP7	-19254.5
IL6ST	-18503.5
CDK1	-16471.5
DUSP10	-16460.5
PEA15	-16372.5
MAP2K1	-16196.5
IL6R	-15462.5
TYK2	-14619.5
DUSP8	-14085.5
DUSP5	-13826.5
PTPN11	-13336.5
JAK2	-12393.5
MAP2K2	-11136.5
MAPK1	-9933.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
JAK1	-21183.5
DUSP6	-20489.5
DUSP4	-20217.5
DUSP16	-20055.5
DUSP2	-19867.5
DUSP1	-19414.5
DUSP7	-19254.5
IL6ST	-18503.5
CDK1	-16471.5
DUSP10	-16460.5
PEA15	-16372.5
MAP2K1	-16196.5
IL6R	-15462.5
TYK2	-14619.5
DUSP8	-14085.5
DUSP5	-13826.5
PTPN11	-13336.5
JAK2	-12393.5
MAP2K2	-11136.5
MAPK1	-9933.5
MAPK3	-3079.5
IL6	0.5

---

RUNX3 regulates p14-ARF

RUNX3 regulates p14-ARF

	1052
set	RUNX3 regulates p14-ARF
setSize	10
pANOVA	0.0115
s.dist	-0.461
p.adjustANOVA	0.0241

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BRD2	-21879.5
KRAS	-21833.5
RUNX3	-19897.5
CBFB	-19675.5
CCND1	-19110.5
HDAC4	-14651.5
EP300	-10926.5
TGFB1	-10577.5
RUNX1	-10285.5
CDKN2A	-1930.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BRD2	-21879.5
KRAS	-21833.5
RUNX3	-19897.5
CBFB	-19675.5
CCND1	-19110.5
HDAC4	-14651.5
EP300	-10926.5
TGFB1	-10577.5
RUNX1	-10285.5
CDKN2A	-1930.5

---

RUNX2 regulates bone development

RUNX2 regulates bone development

	1049
set	RUNX2 regulates bone development
setSize	29
pANOVA	1.96e-05
s.dist	-0.458
p.adjustANOVA	0.000124

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HEY1	-21716.5
SATB2	-21708.5
HES1	-21328.5
YES1	-21017.5
MAF	-20992.5
GLI3	-20691.5
SMAD4	-20586.5
SMAD6	-20523.5
WWTR1	-20496.5
RBM14	-20353.5
CBFB	-19675.5
HDAC3	-17766.5
RB1	-16862.5
HEY2	-16750.5
RUNX2	-16321.5
ZNF521	-16201.5
COL1A1	-15705.5
HDAC4	-14651.5
SMAD1	-14513.5
IHH	-13261.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HEY1	-21716.5
SATB2	-21708.5
HES1	-21328.5
YES1	-21017.5
MAF	-20992.5
GLI3	-20691.5
SMAD4	-20586.5
SMAD6	-20523.5
WWTR1	-20496.5
RBM14	-20353.5
CBFB	-19675.5
HDAC3	-17766.5
RB1	-16862.5
HEY2	-16750.5
RUNX2	-16321.5
ZNF521	-16201.5
COL1A1	-15705.5
HDAC4	-14651.5
SMAD1	-14513.5
IHH	-13261.5
BGLAP	-10681.5
YAP1	-10314.5
MAPK1	-9933.5
SP7	-9895.5
SRC	-6832.5
ABL1	-6737.5
UCMA	-5331.5
MAPK3	-3079.5
GLI2	-1860.5

---

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

	1497
set	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize	12
pANOVA	0.00609
s.dist	-0.457
p.adjustANOVA	0.014

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FADS1	-20574.5
ELOVL2	-19945.5
ACOX1	-19896.5
ELOVL5	-19201.5
ACSL1	-18473.5
ELOVL1	-17675.5
ACOT8	-15932.5
SCP2	-15636.5
FADS2	-13079.5
ACAA1	-8759.5
ELOVL3	-7600.5
HSD17B4	-3478.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FADS1	-20574.5
ELOVL2	-19945.5
ACOX1	-19896.5
ELOVL5	-19201.5
ACSL1	-18473.5
ELOVL1	-17675.5
ACOT8	-15932.5
SCP2	-15636.5
FADS2	-13079.5
ACAA1	-8759.5
ELOVL3	-7600.5
HSD17B4	-3478.5

---

alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism

	1498
set	alpha-linolenic acid (ALA) metabolism
setSize	12
pANOVA	0.00609
s.dist	-0.457
p.adjustANOVA	0.014

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FADS1	-20574.5
ELOVL2	-19945.5
ACOX1	-19896.5
ELOVL5	-19201.5
ACSL1	-18473.5
ELOVL1	-17675.5
ACOT8	-15932.5
SCP2	-15636.5
FADS2	-13079.5
ACAA1	-8759.5
ELOVL3	-7600.5
HSD17B4	-3478.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FADS1	-20574.5
ELOVL2	-19945.5
ACOX1	-19896.5
ELOVL5	-19201.5
ACSL1	-18473.5
ELOVL1	-17675.5
ACOT8	-15932.5
SCP2	-15636.5
FADS2	-13079.5
ACAA1	-8759.5
ELOVL3	-7600.5
HSD17B4	-3478.5

---

RUNX2 regulates osteoblast differentiation

RUNX2 regulates osteoblast differentiation

	1050
set	RUNX2 regulates osteoblast differentiation
setSize	22
pANOVA	0.000213
s.dist	-0.456
p.adjustANOVA	0.000852

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HEY1	-21716.5
SATB2	-21708.5
HES1	-21328.5
YES1	-21017.5
MAF	-20992.5
GLI3	-20691.5
WWTR1	-20496.5
CBFB	-19675.5
HDAC3	-17766.5
RB1	-16862.5
HEY2	-16750.5
RUNX2	-16321.5
ZNF521	-16201.5
COL1A1	-15705.5
BGLAP	-10681.5
YAP1	-10314.5
MAPK1	-9933.5
SP7	-9895.5
SRC	-6832.5
ABL1	-6737.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HEY1	-21716.5
SATB2	-21708.5
HES1	-21328.5
YES1	-21017.5
MAF	-20992.5
GLI3	-20691.5
WWTR1	-20496.5
CBFB	-19675.5
HDAC3	-17766.5
RB1	-16862.5
HEY2	-16750.5
RUNX2	-16321.5
ZNF521	-16201.5
COL1A1	-15705.5
BGLAP	-10681.5
YAP1	-10314.5
MAPK1	-9933.5
SP7	-9895.5
SRC	-6832.5
ABL1	-6737.5
UCMA	-5331.5
MAPK3	-3079.5

---

APC truncation mutants have impaired AXIN binding

APC truncation mutants have impaired AXIN binding

	10
set	APC truncation mutants have impaired AXIN binding
setSize	13
pANOVA	0.00445
s.dist	-0.455
p.adjustANOVA	0.0107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

AXIN missense mutants destabilize the destruction complex

AXIN missense mutants destabilize the destruction complex

	23
set	AXIN missense mutants destabilize the destruction complex
setSize	13
pANOVA	0.00445
s.dist	-0.455
p.adjustANOVA	0.0107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

Signaling by AMER1 mutants

Signaling by AMER1 mutants

	1217
set	Signaling by AMER1 mutants
setSize	13
pANOVA	0.00445
s.dist	-0.455
p.adjustANOVA	0.0107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

Signaling by APC mutants

Signaling by APC mutants

	1218
set	Signaling by APC mutants
setSize	13
pANOVA	0.00445
s.dist	-0.455
p.adjustANOVA	0.0107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

Signaling by AXIN mutants

Signaling by AXIN mutants

	1219
set	Signaling by AXIN mutants
setSize	13
pANOVA	0.00445
s.dist	-0.455
p.adjustANOVA	0.0107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

Truncations of AMER1 destabilize the destruction complex

Truncations of AMER1 destabilize the destruction complex

	1459
set	Truncations of AMER1 destabilize the destruction complex
setSize	13
pANOVA	0.00445
s.dist	-0.455
p.adjustANOVA	0.0107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APC	-21266.5
PPP2R5D	-20498.5
PPP2R1A	-19916.5
PPP2R5B	-19700.5
PPP2R5E	-18559.5
CSNK1A1	-17637.5
PPP2CA	-17300.5
PPP2R5C	-15192.5
PPP2R1B	-15087.5
GSK3B	-12908.5
PPP2R5A	-9471.5
AXIN1	-8669.5
PPP2CB	1209.5

---

RNA Polymerase III Transcription Initiation From Type 2 Promoter

RNA Polymerase III Transcription Initiation From Type 2 Promoter

	1037
set	RNA Polymerase III Transcription Initiation From Type 2 Promoter
setSize	27
pANOVA	4.18e-05
s.dist	-0.455
p.adjustANOVA	0.000223

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR1D	-22069.5
GTF3C4	-21636.5
GTF3C5	-21507.5
POLR3C	-21172.5
POLR2L	-21029.5
TBP	-20975.5
POLR3G	-20575.5
POLR2F	-19650.5
POLR3F	-19387.5
POLR3A	-18155.5
BRF1	-17876.5
POLR3B	-17796.5
POLR3GL	-17541.5
POLR3E	-17398.5
GTF3C2	-16806.5
POLR3D	-15907.5
GTF3C6	-13777.5
GTF3C3	-13676.5
POLR3K	-13612.5
POLR2H	-12642.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR1D	-22069.5
GTF3C4	-21636.5
GTF3C5	-21507.5
POLR3C	-21172.5
POLR2L	-21029.5
TBP	-20975.5
POLR3G	-20575.5
POLR2F	-19650.5
POLR3F	-19387.5
POLR3A	-18155.5
BRF1	-17876.5
POLR3B	-17796.5
POLR3GL	-17541.5
POLR3E	-17398.5
GTF3C2	-16806.5
POLR3D	-15907.5
GTF3C6	-13777.5
GTF3C3	-13676.5
POLR3K	-13612.5
POLR2H	-12642.5
POLR1C	-11111.5
GTF3C1	-10860.5
POLR3H	-8931.5
POLR2E	-6942.5
CRCP	-3591.5
BDP1	-2231.5
POLR2K	2010.5

---

Nephrin family interactions

Nephrin family interactions

	805
set	Nephrin family interactions
setSize	21
pANOVA	0.000331
s.dist	-0.452
p.adjustANOVA	0.00123

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FYN	-21951.5
WASL	-21834.5
PIK3CB	-21815.5
PIK3CA	-20323.5
MAGI2	-20244.5
CD2AP	-19679.5
SPTBN1	-19454.5
ACTN3	-19142.5
KIRREL3	-19031.5
NPHS1	-18484.5
IQGAP1	-16749.5
PIK3R2	-14009.5
KIRREL2	-14004.5
PIK3R1	-13634.5
ACTN4	-13002.5
NCK1	-11715.5
NCK2	-10484.5
SPTAN1	-7766.5
KIRREL	-7307.5
ACTN2	-2173.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FYN	-21951.5
WASL	-21834.5
PIK3CB	-21815.5
PIK3CA	-20323.5
MAGI2	-20244.5
CD2AP	-19679.5
SPTBN1	-19454.5
ACTN3	-19142.5
KIRREL3	-19031.5
NPHS1	-18484.5
IQGAP1	-16749.5
PIK3R2	-14009.5
KIRREL2	-14004.5
PIK3R1	-13634.5
ACTN4	-13002.5
NCK1	-11715.5
NCK2	-10484.5
SPTAN1	-7766.5
KIRREL	-7307.5
ACTN2	-2173.5
ACTN1	-1265.5

---

Cleavage of the damaged purine

Cleavage of the damaged purine

	216
set	Cleavage of the damaged purine
setSize	11
pANOVA	0.00951
s.dist	-0.451
p.adjustANOVA	0.0206

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2AFX	-19427.5
TERF1	-19003.5
TERF2IP	-18747.5
MUTYH	-18425.5
MPG	-16274.5
OGG1	-15696.5
ACD	-13964.0
TINF2	-13631.5
POT1	-12498.5
NEIL3	-11997.5
TERF2	-4746.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2AFX	-19427.5
TERF1	-19003.5
TERF2IP	-18747.5
MUTYH	-18425.5
MPG	-16274.5
OGG1	-15696.5
ACD	-13964.0
TINF2	-13631.5
POT1	-12498.5
NEIL3	-11997.5
TERF2	-4746.5

---

Depurination

Depurination

	309
set	Depurination
setSize	11
pANOVA	0.00951
s.dist	-0.451
p.adjustANOVA	0.0206

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2AFX	-19427.5
TERF1	-19003.5
TERF2IP	-18747.5
MUTYH	-18425.5
MPG	-16274.5
OGG1	-15696.5
ACD	-13964.0
TINF2	-13631.5
POT1	-12498.5
NEIL3	-11997.5
TERF2	-4746.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2AFX	-19427.5
TERF1	-19003.5
TERF2IP	-18747.5
MUTYH	-18425.5
MPG	-16274.5
OGG1	-15696.5
ACD	-13964.0
TINF2	-13631.5
POT1	-12498.5
NEIL3	-11997.5
TERF2	-4746.5

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.2                                       
##  [5] tibble_3.1.7                                       
##  [6] echarts4r_0.4.3                                    
##  [7] ENmix_1.32.0                                       
##  [8] doParallel_1.0.17                                  
##  [9] qqman_0.1.8                                        
## [10] RCircos_1.2.2                                      
## [11] beeswarm_0.4.0                                     
## [12] forestplot_2.0.1                                   
## [13] checkmate_2.1.0                                    
## [14] magrittr_2.0.3                                     
## [15] reshape2_1.4.4                                     
## [16] gplots_3.1.3                                       
## [17] GEOquery_2.64.2                                    
## [18] RColorBrewer_1.1-3                                 
## [19] IlluminaHumanMethylation450kmanifest_0.4.0         
## [20] topconfects_1.12.0                                 
## [21] DMRcatedata_2.14.0                                 
## [22] ExperimentHub_2.4.0                                
## [23] AnnotationHub_3.4.0                                
## [24] BiocFileCache_2.4.0                                
## [25] dbplyr_2.1.1                                       
## [26] DMRcate_2.10.0                                     
## [27] limma_3.52.1                                       
## [28] missMethyl_1.30.0                                  
## [29] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [30] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [31] minfi_1.42.0                                       
## [32] bumphunter_1.38.0                                  
## [33] locfit_1.5-9.5                                     
## [34] iterators_1.0.14                                   
## [35] foreach_1.5.2                                      
## [36] Biostrings_2.64.0                                  
## [37] XVector_0.36.0                                     
## [38] SummarizedExperiment_1.26.1                        
## [39] Biobase_2.56.0                                     
## [40] MatrixGenerics_1.8.0                               
## [41] matrixStats_0.62.0                                 
## [42] GenomicRanges_1.48.0                               
## [43] GenomeInfoDb_1.32.2                                
## [44] IRanges_2.30.0                                     
## [45] S4Vectors_0.34.0                                   
## [46] BiocGenerics_0.42.0                                
## [47] R.utils_2.11.0                                     
## [48] R.oo_1.24.0                                        
## [49] R.methodsS3_1.8.1                                  
## [50] plyr_1.8.7                                         
## [51] tictoc_1.0.1                                       
## [52] mitch_1.8.0                                        
## [53] eulerr_6.1.1                                       
## [54] kableExtra_1.3.4                                   
## [55] dplyr_1.0.9                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.0           
##   [3] tidyr_1.2.0                   bit64_4.0.5                  
##   [5] knitr_1.39                    DelayedArray_0.22.0          
##   [7] data.table_1.14.2             rpart_4.1.16                 
##   [9] KEGGREST_1.36.0               RCurl_1.98-1.6               
##  [11] AnnotationFilter_1.20.0       generics_0.1.2               
##  [13] GenomicFeatures_1.48.1        preprocessCore_1.58.0        
##  [15] RSQLite_2.2.14                bit_4.0.4                    
##  [17] tzdb_0.3.0                    webshot_0.5.3                
##  [19] xml2_1.3.3                    httpuv_1.6.5                 
##  [21] assertthat_0.2.1              xfun_0.31                    
##  [23] hms_1.1.1                     jquerylib_0.1.4              
##  [25] evaluate_0.15                 promises_1.2.0.1             
##  [27] fansi_1.0.3                   restfulr_0.0.13              
##  [29] scrime_1.3.5                  progress_1.2.2               
##  [31] caTools_1.18.2                readxl_1.4.0                 
##  [33] DBI_1.1.2                     geneplotter_1.74.0           
##  [35] htmlwidgets_1.5.4             reshape_0.8.9                
##  [37] purrr_0.3.4                   ellipsis_0.3.2               
##  [39] backports_1.4.1               permute_0.9-7                
##  [41] calibrate_1.7.7               annotate_1.74.0              
##  [43] biomaRt_2.52.0                sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.1                   ensembldb_2.20.1             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.0      prettyunits_1.1.1            
##  [53] mclust_5.4.9                  svglite_2.1.0                
##  [55] cluster_2.1.3                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.1                 
##  [59] genefilter_1.78.0             edgeR_3.38.1                 
##  [61] pkgconfig_2.0.3               nlme_3.1-157                 
##  [63] ProtGenerics_1.28.0           nnet_7.3-17                  
##  [65] rlang_1.0.2                   lifecycle_1.0.1              
##  [67] filelock_1.0.2                dichromat_2.0-0.1            
##  [69] rprojroot_2.0.3               cellranger_1.1.0             
##  [71] rngtools_1.5.2                base64_2.0                   
##  [73] Matrix_1.4-1                  Rhdf5lib_1.18.2              
##  [75] base64enc_0.1-3               png_0.1-7                    
##  [77] viridisLite_0.4.0             rjson_0.2.21                 
##  [79] bitops_1.0-7                  KernSmooth_2.23-20           
##  [81] rhdf5filters_1.8.0            blob_1.2.3                   
##  [83] DelayedMatrixStats_1.18.0     doRNG_1.8.2                  
##  [85] stringr_1.4.0                 nor1mix_1.3-0                
##  [87] readr_2.1.2                   jpeg_0.1-9                   
##  [89] scales_1.2.0                  memoise_2.0.1                
##  [91] zlibbioc_1.42.0               compiler_4.2.0               
##  [93] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [95] Rsamtools_2.12.0              cli_3.3.0                    
##  [97] DSS_2.44.0                    htmlTable_2.4.0              
##  [99] Formula_1.2-4                 MASS_7.3-57                  
## [101] tidyselect_1.1.2              stringi_1.7.6                
## [103] highr_0.9                     yaml_2.3.5                   
## [105] askpass_1.1                   latticeExtra_0.6-29          
## [107] sass_0.4.1                    VariantAnnotation_1.42.1     
## [109] tools_4.2.0                   rstudioapi_0.13              
## [111] foreign_0.8-82                bsseq_1.32.0                 
## [113] gridExtra_2.3                 digest_0.6.29                
## [115] BiocManager_1.30.17           shiny_1.7.1                  
## [117] quadprog_1.5-8                Rcpp_1.0.8.3                 
## [119] siggenes_1.70.0               BiocVersion_3.15.2           
## [121] later_1.3.0                   org.Hs.eg.db_3.15.0          
## [123] httr_1.4.3                    AnnotationDbi_1.58.0         
## [125] biovizBase_1.44.0             colorspace_2.0-3             
## [127] brio_1.1.3                    rvest_1.0.2                  
## [129] XML_3.99-0.9                  splines_4.2.0                
## [131] statmod_1.4.36                multtest_2.52.0              
## [133] systemfonts_1.0.4             xtable_1.8-4                 
## [135] jsonlite_1.8.0                dynamicTreeCut_1.63-1        
## [137] testthat_3.1.4                R6_2.5.1                     
## [139] Hmisc_4.7-0                   pillar_1.7.0                 
## [141] htmltools_0.5.2               mime_0.12                    
## [143] glue_1.6.2                    fastmap_1.1.0                
## [145] BiocParallel_1.30.2           interactiveDisplayBase_1.34.0
## [147] beanplot_1.3.1                codetools_0.2-18             
## [149] utf8_1.2.2                    bslib_0.3.1                  
## [151] lattice_0.20-45               curl_4.3.2                   
## [153] openssl_2.0.1                 survival_3.3-1               
## [155] rmarkdown_2.14                desc_1.4.1                   
## [157] munsell_0.5.0                 rhdf5_2.40.0                 
## [159] GenomeInfoDbData_1.2.8        HDF5Array_1.24.0             
## [161] impute_1.70.0                 gtable_0.3.0

END of report