date generated: 2023-10-06

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
bu
FLNC 0.4697347
TMEM91 0.4610404
CSNK1A1 0.5673118
LINC01273 -0.1819099
MIR124-2 -0.8328384
CPN2 0.7720343

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2584
num_genes_in_profile 25739
duplicated_genes_present 0
num_profile_genes_in_sets 10218
num_profile_genes_not_in_sets 15521

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways.gmt
Gene set metrics
Gene sets metrics
num_genesets 2584
num_genesets_excluded 1038
num_genesets_included 1546

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
Chylomicron remodeling 10 3.05e-03 0.541 8.13e-02
TRAF6 mediated IRF7 activation 26 2.37e-05 -0.479 1.27e-03
SARS-CoV-1 modulates host translation machinery 34 8.57e-06 0.441 5.09e-04
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 9.89e-03 -0.430 2.07e-01
Interaction With Cumulus Cells And The Zona Pellucida 11 1.70e-02 -0.416 2.91e-01
Expression and translocation of olfactory receptors 358 2.87e-37 -0.391 4.43e-34
Class C/3 (Metabotropic glutamate/pheromone receptors) 39 2.37e-05 -0.391 1.27e-03
Caspase activation via Death Receptors in the presence of ligand 16 8.13e-03 -0.382 1.75e-01
Olfactory Signaling Pathway 365 4.02e-36 -0.381 3.11e-33
Glucuronidation 25 1.16e-03 -0.375 4.17e-02
Diseases associated with glycosylation precursor biosynthesis 15 1.19e-02 0.375 2.30e-01
Chylomicron assembly 10 4.23e-02 0.371 4.91e-01
Phase 4 - resting membrane potential 19 6.33e-03 0.362 1.46e-01
mRNA Editing 10 5.27e-02 -0.354 5.69e-01
NF-kB is activated and signals survival 12 3.44e-02 0.353 4.38e-01
Signaling by cytosolic FGFR1 fusion mutants 17 1.24e-02 -0.350 2.36e-01
Synthesis of PIPs at the late endosome membrane 10 6.56e-02 -0.336 6.11e-01
Viral mRNA Translation 84 1.40e-07 0.332 2.70e-05
Cytosolic iron-sulfur cluster assembly 10 7.01e-02 0.331 6.23e-01
Regulation of NF-kappa B signaling 17 1.83e-02 0.330 3.05e-01
Eukaryotic Translation Termination 87 1.07e-07 0.329 2.70e-05
Peptide chain elongation 84 2.21e-07 0.327 3.45e-05
Regulation of IFNA/IFNB signaling 22 8.14e-03 -0.326 1.75e-01
Pexophagy 11 6.45e-02 0.322 6.08e-01
Telomere C-strand synthesis initiation 11 6.69e-02 -0.319 6.17e-01
p75NTR recruits signalling complexes 12 5.57e-02 0.319 5.83e-01
p75NTR signals via NF-kB 15 3.27e-02 0.318 4.29e-01
Intrinsic Pathway of Fibrin Clot Formation 21 1.15e-02 -0.318 2.29e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 89 2.67e-07 0.315 3.45e-05
Selenocysteine synthesis 87 4.02e-07 0.314 4.61e-05
Eukaryotic Translation Elongation 88 4.17e-07 0.312 4.61e-05
TRAF3-dependent IRF activation pathway 15 3.68e-02 -0.311 4.41e-01
Platelet Adhesion to exposed collagen 13 5.24e-02 -0.311 5.69e-01
SUMOylation of immune response proteins 10 9.25e-02 0.307 6.73e-01
Metabolism of folate and pterines 16 3.41e-02 -0.306 4.38e-01
Alpha-protein kinase 1 signaling pathway 10 9.69e-02 0.303 6.75e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 54 1.48e-04 0.298 6.55e-03
Translation initiation complex formation 53 1.78e-04 0.298 7.64e-03
Biosynthesis of DHA-derived SPMs 17 3.48e-02 0.296 4.38e-01
Pausing and recovery of Tat-mediated HIV elongation 27 8.16e-03 0.294 1.75e-01
Tat-mediated HIV elongation arrest and recovery 27 8.16e-03 0.294 1.75e-01
Selenoamino acid metabolism 103 2.62e-07 0.293 3.45e-05
Formation of the ternary complex, and subsequently, the 43S complex 46 5.76e-04 0.293 2.33e-02
SARS-CoV-2 modulates host translation machinery 46 5.87e-04 0.293 2.33e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 9.64e-02 0.289 6.75e-01
STAT5 activation downstream of FLT3 ITD mutants 10 1.13e-01 -0.289 7.01e-01
Receptor Mediated Mitophagy 10 1.13e-01 0.289 7.01e-01
DAP12 interactions 40 1.56e-03 -0.289 5.36e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.16e-01 0.287 7.06e-01
Ribosomal scanning and start codon recognition 53 3.12e-04 0.286 1.30e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Chylomicron remodeling 10 3.05e-03 5.41e-01 8.13e-02
TRAF6 mediated IRF7 activation 26 2.37e-05 -4.79e-01 1.27e-03
SARS-CoV-1 modulates host translation machinery 34 8.57e-06 4.41e-01 5.09e-04
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 9.89e-03 -4.30e-01 2.07e-01
Interaction With Cumulus Cells And The Zona Pellucida 11 1.70e-02 -4.16e-01 2.91e-01
Expression and translocation of olfactory receptors 358 2.87e-37 -3.91e-01 4.43e-34
Class C/3 (Metabotropic glutamate/pheromone receptors) 39 2.37e-05 -3.91e-01 1.27e-03
Caspase activation via Death Receptors in the presence of ligand 16 8.13e-03 -3.82e-01 1.75e-01
Olfactory Signaling Pathway 365 4.02e-36 -3.81e-01 3.11e-33
Glucuronidation 25 1.16e-03 -3.75e-01 4.17e-02
Diseases associated with glycosylation precursor biosynthesis 15 1.19e-02 3.75e-01 2.30e-01
Chylomicron assembly 10 4.23e-02 3.71e-01 4.91e-01
Phase 4 - resting membrane potential 19 6.33e-03 3.62e-01 1.46e-01
mRNA Editing 10 5.27e-02 -3.54e-01 5.69e-01
NF-kB is activated and signals survival 12 3.44e-02 3.53e-01 4.38e-01
Signaling by cytosolic FGFR1 fusion mutants 17 1.24e-02 -3.50e-01 2.36e-01
Synthesis of PIPs at the late endosome membrane 10 6.56e-02 -3.36e-01 6.11e-01
Viral mRNA Translation 84 1.40e-07 3.32e-01 2.70e-05
Cytosolic iron-sulfur cluster assembly 10 7.01e-02 3.31e-01 6.23e-01
Regulation of NF-kappa B signaling 17 1.83e-02 3.30e-01 3.05e-01
Eukaryotic Translation Termination 87 1.07e-07 3.29e-01 2.70e-05
Peptide chain elongation 84 2.21e-07 3.27e-01 3.45e-05
Regulation of IFNA/IFNB signaling 22 8.14e-03 -3.26e-01 1.75e-01
Pexophagy 11 6.45e-02 3.22e-01 6.08e-01
Telomere C-strand synthesis initiation 11 6.69e-02 -3.19e-01 6.17e-01
p75NTR recruits signalling complexes 12 5.57e-02 3.19e-01 5.83e-01
p75NTR signals via NF-kB 15 3.27e-02 3.18e-01 4.29e-01
Intrinsic Pathway of Fibrin Clot Formation 21 1.15e-02 -3.18e-01 2.29e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 89 2.67e-07 3.15e-01 3.45e-05
Selenocysteine synthesis 87 4.02e-07 3.14e-01 4.61e-05
Eukaryotic Translation Elongation 88 4.17e-07 3.12e-01 4.61e-05
TRAF3-dependent IRF activation pathway 15 3.68e-02 -3.11e-01 4.41e-01
Platelet Adhesion to exposed collagen 13 5.24e-02 -3.11e-01 5.69e-01
SUMOylation of immune response proteins 10 9.25e-02 3.07e-01 6.73e-01
Metabolism of folate and pterines 16 3.41e-02 -3.06e-01 4.38e-01
Alpha-protein kinase 1 signaling pathway 10 9.69e-02 3.03e-01 6.75e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 54 1.48e-04 2.98e-01 6.55e-03
Translation initiation complex formation 53 1.78e-04 2.98e-01 7.64e-03
Biosynthesis of DHA-derived SPMs 17 3.48e-02 2.96e-01 4.38e-01
Pausing and recovery of Tat-mediated HIV elongation 27 8.16e-03 2.94e-01 1.75e-01
Tat-mediated HIV elongation arrest and recovery 27 8.16e-03 2.94e-01 1.75e-01
Selenoamino acid metabolism 103 2.62e-07 2.93e-01 3.45e-05
Formation of the ternary complex, and subsequently, the 43S complex 46 5.76e-04 2.93e-01 2.33e-02
SARS-CoV-2 modulates host translation machinery 46 5.87e-04 2.93e-01 2.33e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 9.64e-02 2.89e-01 6.75e-01
STAT5 activation downstream of FLT3 ITD mutants 10 1.13e-01 -2.89e-01 7.01e-01
Receptor Mediated Mitophagy 10 1.13e-01 2.89e-01 7.01e-01
DAP12 interactions 40 1.56e-03 -2.89e-01 5.36e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.16e-01 2.87e-01 7.06e-01
Ribosomal scanning and start codon recognition 53 3.12e-04 2.86e-01 1.30e-02
Interleukin-15 signaling 13 7.56e-02 -2.85e-01 6.32e-01
Recycling of bile acids and salts 18 3.69e-02 -2.84e-01 4.41e-01
Synthesis of PIPs at the early endosome membrane 15 5.82e-02 -2.82e-01 5.84e-01
Formation of a pool of free 40S subunits 94 2.23e-06 2.82e-01 1.50e-04
Response of EIF2AK4 (GCN2) to amino acid deficiency 95 1.98e-06 2.82e-01 1.39e-04
Interleukin-2 family signaling 40 2.06e-03 -2.82e-01 6.36e-02
Downregulation of ERBB2:ERBB3 signaling 13 8.02e-02 2.80e-01 6.39e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 10 1.28e-01 2.78e-01 7.28e-01
Josephin domain DUBs 11 1.15e-01 2.74e-01 7.06e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 41 2.38e-03 -2.74e-01 6.95e-02
Neurotoxicity of clostridium toxins 10 1.35e-01 2.73e-01 7.33e-01
L13a-mediated translational silencing of Ceruloplasmin expression 103 1.66e-06 2.73e-01 1.22e-04
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 108 1.32e-06 2.69e-01 1.13e-04
Nonsense-Mediated Decay (NMD) 108 1.32e-06 2.69e-01 1.13e-04
HSF1-dependent transactivation 35 5.87e-03 2.69e-01 1.38e-01
Assembly of active LPL and LIPC lipase complexes 17 5.61e-02 2.68e-01 5.83e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 104 2.40e-06 2.67e-01 1.55e-04
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 8.40e-02 2.67e-01 6.52e-01
HIV elongation arrest and recovery 29 1.29e-02 2.67e-01 2.38e-01
Pausing and recovery of HIV elongation 29 1.29e-02 2.67e-01 2.38e-01
Cap-dependent Translation Initiation 111 1.57e-06 2.64e-01 1.21e-04
Eukaryotic Translation Initiation 111 1.57e-06 2.64e-01 1.21e-04
Early Phase of HIV Life Cycle 14 9.98e-02 2.54e-01 6.75e-01
Regulation of signaling by NODAL 10 1.64e-01 2.54e-01 7.41e-01
Triglyceride catabolism 23 3.71e-02 -2.51e-01 4.41e-01
Major pathway of rRNA processing in the nucleolus and cytosol 171 1.52e-08 2.51e-01 5.89e-06
CASP8 activity is inhibited 11 1.50e-01 -2.50e-01 7.37e-01
Dimerization of procaspase-8 11 1.50e-01 -2.50e-01 7.37e-01
Regulation by c-FLIP 11 1.50e-01 -2.50e-01 7.37e-01
SRP-dependent cotranslational protein targeting to membrane 105 1.06e-05 2.49e-01 6.09e-04
Sema4D induced cell migration and growth-cone collapse 20 5.77e-02 2.45e-01 5.83e-01
NRIF signals cell death from the nucleus 16 9.07e-02 2.44e-01 6.71e-01
Assembly Of The HIV Virion 16 9.08e-02 2.44e-01 6.71e-01
Role of LAT2/NTAL/LAB on calcium mobilization 13 1.29e-01 -2.43e-01 7.28e-01
MyD88 deficiency (TLR2/4) 16 9.25e-02 -2.43e-01 6.73e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 23 4.45e-02 2.42e-01 5.02e-01
Sensory Perception 569 6.53e-23 -2.41e-01 3.36e-20
VLDLR internalisation and degradation 16 9.60e-02 2.40e-01 6.75e-01
DAP12 signaling 28 2.79e-02 -2.40e-01 3.85e-01
Tandem pore domain potassium channels 12 1.50e-01 2.40e-01 7.37e-01
Tie2 Signaling 18 7.85e-02 -2.40e-01 6.39e-01
IRAK4 deficiency (TLR2/4) 17 8.75e-02 -2.39e-01 6.63e-01
Signaling by FLT3 fusion proteins 19 7.33e-02 -2.37e-01 6.28e-01
Cellular response to starvation 147 7.98e-07 2.36e-01 8.22e-05
Attenuation phase 25 4.29e-02 2.34e-01 4.95e-01
rRNA processing in the nucleus and cytosol 180 6.92e-08 2.33e-01 2.14e-05
Signal regulatory protein family interactions 13 1.48e-01 -2.32e-01 7.37e-01
Interleukin-2 signaling 11 1.84e-01 -2.31e-01 7.67e-01
Phospholipase C-mediated cascade: FGFR1 16 1.11e-01 2.30e-01 6.96e-01
Chemokine receptors bind chemokines 56 2.91e-03 -2.30e-01 7.98e-02
Glyoxylate metabolism and glycine degradation 30 2.95e-02 2.30e-01 3.94e-01
Degradation of cysteine and homocysteine 14 1.39e-01 2.28e-01 7.37e-01
Spry regulation of FGF signaling 16 1.16e-01 2.27e-01 7.06e-01
Regulation of localization of FOXO transcription factors 11 1.93e-01 2.26e-01 7.73e-01
Organic cation transport 10 2.15e-01 -2.26e-01 7.82e-01
Plasma lipoprotein assembly 19 8.95e-02 2.25e-01 6.71e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 6.20e-02 2.25e-01 6.02e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 1.33e-01 2.24e-01 7.28e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 1.33e-01 2.24e-01 7.28e-01
rRNA processing 186 1.39e-07 2.24e-01 2.70e-05
Caspase activation via extrinsic apoptotic signalling pathway 25 5.35e-02 -2.23e-01 5.74e-01
Signaling by EGFR in Cancer 25 5.45e-02 2.22e-01 5.81e-01
Gap junction degradation 10 2.24e-01 -2.22e-01 7.82e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 6.10e-02 2.21e-01 6.01e-01
Regulation of PTEN mRNA translation 25 5.72e-02 2.20e-01 5.83e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 2.42e-02 2.17e-01 3.64e-01
NPAS4 regulates expression of target genes 21 8.53e-02 2.17e-01 6.53e-01
rRNA modification in the nucleus and cytosol 55 5.42e-03 2.17e-01 1.29e-01
MET receptor recycling 10 2.37e-01 2.16e-01 7.98e-01
Transcriptional regulation of testis differentiation 12 1.96e-01 -2.16e-01 7.73e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 7.99e-02 2.16e-01 6.39e-01
Scavenging of heme from plasma 12 1.96e-01 -2.16e-01 7.73e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.63e-01 2.15e-01 7.37e-01
Negative regulation of FGFR1 signaling 32 3.54e-02 2.15e-01 4.41e-01
FGFR1 ligand binding and activation 15 1.50e-01 2.15e-01 7.37e-01
Regulation of expression of SLITs and ROBOs 159 3.18e-06 2.14e-01 1.97e-04
mTORC1-mediated signalling 23 7.63e-02 2.14e-01 6.34e-01
Acyl chain remodelling of PE 24 7.18e-02 2.12e-01 6.27e-01
Regulation of innate immune responses to cytosolic DNA 14 1.69e-01 2.12e-01 7.53e-01
Initial triggering of complement 21 9.28e-02 2.12e-01 6.73e-01
Regulation of TLR by endogenous ligand 17 1.30e-01 -2.12e-01 7.28e-01
Methylation 14 1.71e-01 2.12e-01 7.53e-01
Formation of Fibrin Clot (Clotting Cascade) 37 2.64e-02 -2.11e-01 3.76e-01
Sema4D in semaphorin signaling 24 7.44e-02 2.10e-01 6.28e-01
HSF1 activation 27 5.86e-02 2.10e-01 5.85e-01
Cleavage of the damaged purine 11 2.27e-01 -2.10e-01 7.82e-01
Depurination 11 2.27e-01 -2.10e-01 7.82e-01
Recognition and association of DNA glycosylase with site containing an affected purine 11 2.27e-01 -2.10e-01 7.82e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 15 1.61e-01 -2.09e-01 7.37e-01
cGMP effects 15 1.61e-01 -2.09e-01 7.37e-01
N-Glycan antennae elongation 15 1.62e-01 -2.09e-01 7.37e-01
Reactions specific to the complex N-glycan synthesis pathway 10 2.54e-01 -2.08e-01 8.14e-01
Membrane binding and targetting of GAG proteins 14 1.79e-01 2.08e-01 7.64e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 1.79e-01 2.08e-01 7.64e-01
XBP1(S) activates chaperone genes 47 1.39e-02 2.07e-01 2.47e-01
Biosynthesis of specialized proresolving mediators (SPMs) 19 1.18e-01 2.07e-01 7.09e-01
Influenza Viral RNA Transcription and Replication 129 5.17e-05 2.06e-01 2.42e-03
Receptor-type tyrosine-protein phosphatases 16 1.54e-01 2.06e-01 7.37e-01
GPVI-mediated activation cascade 32 4.41e-02 -2.06e-01 5.01e-01
Aspirin ADME 44 1.91e-02 -2.04e-01 3.10e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 38 2.96e-02 2.04e-01 3.94e-01
HIV Transcription Elongation 38 2.96e-02 2.04e-01 3.94e-01
Tat-mediated elongation of the HIV-1 transcript 38 2.96e-02 2.04e-01 3.94e-01
Keratan sulfate degradation 12 2.25e-01 -2.02e-01 7.82e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 15 1.79e-01 -2.00e-01 7.64e-01
Aggrephagy 23 9.74e-02 2.00e-01 6.75e-01
Interconversion of nucleotide di- and triphosphates 29 6.32e-02 1.99e-01 6.03e-01
N-glycan antennae elongation in the medial/trans-Golgi 26 7.89e-02 -1.99e-01 6.39e-01
Bile acid and bile salt metabolism 45 2.10e-02 -1.99e-01 3.21e-01
Regulation of NPAS4 gene expression 13 2.15e-01 1.99e-01 7.82e-01
Condensation of Prometaphase Chromosomes 11 2.55e-01 1.98e-01 8.14e-01
Thyroxine biosynthesis 10 2.81e-01 -1.97e-01 8.20e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 20 1.30e-01 -1.96e-01 7.28e-01
IRE1alpha activates chaperones 49 1.82e-02 1.95e-01 3.05e-01
Mitochondrial translation termination 87 1.69e-03 1.95e-01 5.45e-02
Acyl chain remodelling of PC 26 8.64e-02 1.94e-01 6.58e-01
Mitochondrial translation initiation 87 1.77e-03 1.94e-01 5.60e-02
Acyl chain remodelling of PI 16 1.80e-01 1.94e-01 7.64e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 20 1.35e-01 1.93e-01 7.33e-01
Na+/Cl- dependent neurotransmitter transporters 18 1.56e-01 1.93e-01 7.37e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 2.48e-01 1.93e-01 8.07e-01
Budding and maturation of HIV virion 28 7.90e-02 1.92e-01 6.39e-01
SARS-CoV-1-host interactions 90 1.66e-03 1.92e-01 5.45e-02
Signaling by FGFR1 49 2.02e-02 1.92e-01 3.19e-01
MAP2K and MAPK activation 36 4.66e-02 -1.92e-01 5.22e-01
MTOR signalling 40 3.61e-02 1.91e-01 4.41e-01
TAK1-dependent IKK and NF-kappa-B activation 41 3.40e-02 1.91e-01 4.38e-01
Negative regulation of FGFR4 signaling 30 7.01e-02 1.91e-01 6.23e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 1.75e-01 -1.90e-01 7.59e-01
Synthesis of PE 12 2.55e-01 1.90e-01 8.14e-01
Signaling by NODAL 21 1.33e-01 1.89e-01 7.28e-01
Regulation of gene expression by Hypoxia-inducible Factor 11 2.78e-01 1.89e-01 8.20e-01
Formation of HIV elongation complex in the absence of HIV Tat 40 3.90e-02 1.89e-01 4.61e-01
Sensory perception of taste 47 2.54e-02 -1.88e-01 3.73e-01
Transcriptional Regulation by NPAS4 33 6.14e-02 1.88e-01 6.01e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 1.04e-01 1.88e-01 6.75e-01
GAB1 signalosome 17 1.82e-01 1.87e-01 7.64e-01
Retinoid metabolism and transport 42 3.67e-02 1.86e-01 4.41e-01
Mitochondrial translation elongation 87 2.70e-03 1.86e-01 7.59e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 1.72e-01 1.86e-01 7.57e-01
Heme degradation 16 1.98e-01 -1.86e-01 7.73e-01
Signaling by FLT3 ITD and TKD mutants 16 1.99e-01 -1.85e-01 7.73e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 31 7.41e-02 1.85e-01 6.28e-01
Translation 262 2.42e-07 1.85e-01 3.45e-05
RNA Polymerase III Transcription Termination 23 1.25e-01 1.85e-01 7.22e-01
Defective pyroptosis 11 2.89e-01 -1.85e-01 8.21e-01
Mitochondrial translation 93 2.20e-03 1.84e-01 6.68e-02
RMTs methylate histone arginines 30 8.25e-02 1.83e-01 6.48e-01
Phospholipase C-mediated cascade; FGFR4 14 2.40e-01 1.81e-01 8.04e-01
Signaling by KIT in disease 20 1.61e-01 -1.81e-01 7.37e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 1.61e-01 -1.81e-01 7.37e-01
ERKs are inactivated 13 2.62e-01 1.80e-01 8.19e-01
Organic anion transporters 10 3.29e-01 1.78e-01 8.37e-01
Common Pathway of Fibrin Clot Formation 21 1.58e-01 -1.78e-01 7.37e-01
ER Quality Control Compartment (ERQC) 20 1.70e-01 1.77e-01 7.53e-01
Formation of RNA Pol II elongation complex 53 2.61e-02 1.77e-01 3.76e-01
RNA Polymerase II Transcription Elongation 53 2.61e-02 1.77e-01 3.76e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 3.11e-01 1.77e-01 8.23e-01
Prednisone ADME 10 3.34e-01 -1.77e-01 8.37e-01
Selective autophagy 59 1.93e-02 1.76e-01 3.10e-01
RHO GTPases Activate ROCKs 19 1.86e-01 1.75e-01 7.67e-01
RHO GTPases activate CIT 19 1.86e-01 1.75e-01 7.67e-01
Phase 2 - plateau phase 14 2.57e-01 1.75e-01 8.17e-01
Signaling by BMP 27 1.17e-01 -1.74e-01 7.06e-01
Other interleukin signaling 24 1.40e-01 1.74e-01 7.37e-01
Regulated proteolysis of p75NTR 11 3.19e-01 1.73e-01 8.29e-01
A tetrasaccharide linker sequence is required for GAG synthesis 23 1.52e-01 1.73e-01 7.37e-01
Triglyceride metabolism 36 7.31e-02 -1.73e-01 6.28e-01
SUMOylation of ubiquitinylation proteins 37 6.99e-02 -1.72e-01 6.23e-01
Citric acid cycle (TCA cycle) 21 1.74e-01 1.72e-01 7.58e-01
Zinc influx into cells by the SLC39 gene family 10 3.50e-01 1.71e-01 8.37e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 2.23e-01 1.71e-01 7.82e-01
Negative regulation of FGFR2 signaling 33 9.03e-02 1.70e-01 6.71e-01
Androgen biosynthesis 11 3.30e-01 -1.70e-01 8.37e-01
Activation of AMPK downstream of NMDARs 10 3.57e-01 1.68e-01 8.43e-01
Signaling by ROBO receptors 203 3.85e-05 1.67e-01 1.98e-03
Formation of the Early Elongation Complex 32 1.01e-01 1.67e-01 6.75e-01
Formation of the HIV-1 Early Elongation Complex 32 1.01e-01 1.67e-01 6.75e-01
Plasma lipoprotein remodeling 32 1.02e-01 1.67e-01 6.75e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 120 1.63e-03 -1.66e-01 5.45e-02
NCAM1 interactions 36 8.45e-02 1.66e-01 6.52e-01
Insulin receptor recycling 26 1.43e-01 1.66e-01 7.37e-01
Sulfur amino acid metabolism 27 1.36e-01 1.66e-01 7.37e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 18 2.25e-01 1.65e-01 7.82e-01
Hormone ligand-binding receptors 13 3.03e-01 -1.65e-01 8.21e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 3.03e-01 1.65e-01 8.21e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 25 1.54e-01 1.65e-01 7.37e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 110 2.94e-03 -1.64e-01 7.98e-02
RHO GTPases activate PKNs 34 9.84e-02 1.64e-01 6.75e-01
Activation of HOX genes during differentiation 61 2.71e-02 1.64e-01 3.78e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 61 2.71e-02 1.64e-01 3.78e-01
Signaling by FGFR4 40 7.38e-02 1.63e-01 6.28e-01
NOTCH2 intracellular domain regulates transcription 11 3.48e-01 -1.63e-01 8.37e-01
mRNA Splicing - Minor Pathway 51 4.39e-02 1.63e-01 5.01e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11 3.50e-01 1.63e-01 8.37e-01
MECP2 regulates neuronal receptors and channels 17 2.46e-01 -1.63e-01 8.07e-01
GRB2 events in EGFR signaling 13 3.11e-01 1.62e-01 8.23e-01
Antimicrobial peptides 78 1.43e-02 -1.60e-01 2.51e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 2.27e-01 1.60e-01 7.82e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 2.27e-01 1.60e-01 7.82e-01
TBC/RABGAPs 42 7.30e-02 1.60e-01 6.28e-01
FGFR4 ligand binding and activation 13 3.19e-01 1.60e-01 8.29e-01
Cell-extracellular matrix interactions 14 3.01e-01 1.60e-01 8.21e-01
Defective B4GALT7 causes EDS, progeroid type 17 2.55e-01 1.59e-01 8.14e-01
Interactions of Vpr with host cellular proteins 33 1.13e-01 -1.59e-01 7.01e-01
Germ layer formation at gastrulation 16 2.70e-01 -1.59e-01 8.19e-01
SUMOylation of DNA damage response and repair proteins 71 2.08e-02 -1.59e-01 3.21e-01
Myogenesis 29 1.40e-01 -1.58e-01 7.37e-01
Regulation of FZD by ubiquitination 21 2.10e-01 1.58e-01 7.82e-01
FLT3 signaling in disease 28 1.52e-01 -1.56e-01 7.37e-01
Synthesis of substrates in N-glycan biosythesis 60 3.63e-02 1.56e-01 4.41e-01
Activation of RAC1 11 3.73e-01 -1.55e-01 8.58e-01
RHOU GTPase cycle 37 1.03e-01 -1.55e-01 6.75e-01
Glutamate Neurotransmitter Release Cycle 23 1.98e-01 1.55e-01 7.73e-01
Transport of organic anions 10 3.96e-01 -1.55e-01 8.64e-01
Influenza Infection 148 1.19e-03 1.54e-01 4.19e-02
Signaling by Leptin 11 3.77e-01 -1.54e-01 8.58e-01
SUMOylation of intracellular receptors 29 1.51e-01 -1.54e-01 7.37e-01
SARS-CoV-2 modulates autophagy 11 3.77e-01 -1.54e-01 8.58e-01
Negative regulation of FGFR3 signaling 28 1.59e-01 1.54e-01 7.37e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 1.59e-01 1.54e-01 7.37e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 2.25e-02 1.53e-01 3.42e-01
Mitotic Telophase/Cytokinesis 10 4.02e-01 -1.53e-01 8.65e-01
Downstream signaling of activated FGFR1 31 1.41e-01 1.53e-01 7.37e-01
Erythrocytes take up carbon dioxide and release oxygen 12 3.61e-01 1.52e-01 8.43e-01
O2/CO2 exchange in erythrocytes 12 3.61e-01 1.52e-01 8.43e-01
Incretin synthesis, secretion, and inactivation 23 2.06e-01 -1.52e-01 7.79e-01
Calnexin/calreticulin cycle 25 1.88e-01 1.52e-01 7.71e-01
p38MAPK events 13 3.42e-01 1.52e-01 8.37e-01
Association of TriC/CCT with target proteins during biosynthesis 38 1.05e-01 -1.52e-01 6.75e-01
Pregnenolone biosynthesis 10 4.06e-01 1.52e-01 8.66e-01
Metabolism of Angiotensinogen to Angiotensins 15 3.11e-01 -1.51e-01 8.23e-01
RHO GTPases activate PAKs 19 2.54e-01 1.51e-01 8.14e-01
FCERI mediated Ca+2 mobilization 27 1.75e-01 -1.51e-01 7.59e-01
Transport of Ribonucleoproteins into the Host Nucleus 30 1.53e-01 -1.51e-01 7.37e-01
Norepinephrine Neurotransmitter Release Cycle 16 2.97e-01 1.51e-01 8.21e-01
EGFR downregulation 30 1.54e-01 1.50e-01 7.37e-01
Folding of actin by CCT/TriC 10 4.11e-01 -1.50e-01 8.66e-01
NS1 Mediated Effects on Host Pathways 39 1.05e-01 -1.50e-01 6.75e-01
Formation of TC-NER Pre-Incision Complex 51 6.50e-02 1.49e-01 6.09e-01
FOXO-mediated transcription of cell cycle genes 16 3.01e-01 1.49e-01 8.21e-01
Amino acids regulate mTORC1 52 6.28e-02 1.49e-01 6.03e-01
G beta:gamma signalling through BTK 17 2.88e-01 -1.49e-01 8.21e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 3.35e-01 1.49e-01 8.37e-01
ADP signalling through P2Y purinoceptor 12 22 2.27e-01 -1.49e-01 7.82e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 75 2.65e-02 -1.48e-01 3.76e-01
NEP/NS2 Interacts with the Cellular Export Machinery 30 1.61e-01 -1.48e-01 7.37e-01
RNA Polymerase III Chain Elongation 18 2.78e-01 1.48e-01 8.20e-01
Acyl chain remodelling of PG 18 2.78e-01 1.48e-01 8.20e-01
Eicosanoids 12 3.76e-01 1.47e-01 8.58e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 37 1.21e-01 1.47e-01 7.12e-01
Uptake and function of anthrax toxins 11 3.99e-01 -1.47e-01 8.64e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 3.10e-01 1.47e-01 8.23e-01
Signaling by FGFR 85 1.97e-02 1.46e-01 3.14e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 3.61e-01 1.46e-01 8.44e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 28 1.82e-01 -1.46e-01 7.64e-01
Lysine catabolism 12 3.83e-01 -1.46e-01 8.60e-01
FGFRL1 modulation of FGFR1 signaling 13 3.64e-01 1.45e-01 8.47e-01
RNA Polymerase I Transcription Termination 27 1.92e-01 1.45e-01 7.71e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 15 3.33e-01 1.44e-01 8.37e-01
Apoptotic factor-mediated response 17 3.03e-01 -1.44e-01 8.21e-01
Signaling by SCF-KIT 43 1.03e-01 -1.44e-01 6.75e-01
p130Cas linkage to MAPK signaling for integrins 15 3.35e-01 -1.44e-01 8.37e-01
Formation of tubulin folding intermediates by CCT/TriC 26 2.05e-01 -1.43e-01 7.79e-01
CYP2E1 reactions 11 4.10e-01 -1.43e-01 8.66e-01
Intra-Golgi traffic 43 1.04e-01 -1.43e-01 6.75e-01
FGFR2 mutant receptor activation 32 1.62e-01 1.43e-01 7.37e-01
Regulation of TP53 Activity through Association with Co-factors 14 3.55e-01 1.43e-01 8.43e-01
Phospholipase C-mediated cascade; FGFR2 17 3.08e-01 1.43e-01 8.23e-01
Defective B3GAT3 causes JDSSDHD 17 3.08e-01 1.43e-01 8.23e-01
Cytochrome c-mediated apoptotic response 12 3.92e-01 -1.43e-01 8.64e-01
Cyclin D associated events in G1 46 9.37e-02 1.43e-01 6.74e-01
G1 Phase 46 9.37e-02 1.43e-01 6.74e-01
Induction of Cell-Cell Fusion 12 3.92e-01 1.43e-01 8.64e-01
Glutamate and glutamine metabolism 12 3.92e-01 1.43e-01 8.64e-01
Transcriptional Regulation by MECP2 60 5.70e-02 -1.42e-01 5.83e-01
Positive epigenetic regulation of rRNA expression 43 1.07e-01 1.42e-01 6.81e-01
Hh mutants are degraded by ERAD 54 7.14e-02 1.42e-01 6.27e-01
Metabolism of fat-soluble vitamins 46 9.61e-02 1.42e-01 6.75e-01
Zinc transporters 17 3.12e-01 1.42e-01 8.23e-01
Glucocorticoid biosynthesis 10 4.38e-01 1.42e-01 8.76e-01
DNA Damage Recognition in GG-NER 36 1.41e-01 1.42e-01 7.37e-01
Defective GALNT12 causes CRCS1 18 2.98e-01 1.42e-01 8.21e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.03e-01 1.41e-01 7.79e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 3.60e-01 1.41e-01 8.43e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29 1.88e-01 -1.41e-01 7.71e-01
Fertilization 26 2.14e-01 -1.41e-01 7.82e-01
CD209 (DC-SIGN) signaling 20 2.77e-01 -1.40e-01 8.20e-01
MicroRNA (miRNA) biogenesis 26 2.16e-01 1.40e-01 7.82e-01
RNA Pol II CTD phosphorylation and interaction with CE 26 2.17e-01 1.40e-01 7.82e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 26 2.17e-01 1.40e-01 7.82e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 29 1.92e-01 1.40e-01 7.71e-01
Meiotic recombination 26 2.17e-01 -1.40e-01 7.82e-01
Interleukin-20 family signaling 24 2.36e-01 -1.40e-01 7.98e-01
Downregulation of ERBB2 signaling 28 2.03e-01 1.39e-01 7.79e-01
Butyrophilin (BTN) family interactions 12 4.04e-01 -1.39e-01 8.66e-01
Transferrin endocytosis and recycling 30 1.87e-01 1.39e-01 7.71e-01
Laminin interactions 23 2.50e-01 1.39e-01 8.09e-01
Vpr-mediated nuclear import of PICs 32 1.75e-01 -1.38e-01 7.59e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 30 1.90e-01 -1.38e-01 7.71e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 30 1.90e-01 -1.38e-01 7.71e-01
PI-3K cascade:FGFR1 21 2.74e-01 1.38e-01 8.20e-01
Serotonin Neurotransmitter Release Cycle 16 3.40e-01 1.38e-01 8.37e-01
Depolymerisation of the Nuclear Lamina 14 3.73e-01 1.37e-01 8.58e-01
Peroxisomal lipid metabolism 28 2.09e-01 1.37e-01 7.82e-01
SLBP independent Processing of Histone Pre-mRNAs 10 4.53e-01 1.37e-01 8.76e-01
Smooth Muscle Contraction 43 1.20e-01 1.37e-01 7.12e-01
Voltage gated Potassium channels 42 1.25e-01 1.37e-01 7.22e-01
SUMOylation of chromatin organization proteins 54 8.23e-02 -1.37e-01 6.48e-01
FOXO-mediated transcription 65 5.69e-02 1.37e-01 5.83e-01
Transport of vitamins, nucleosides, and related molecules 38 1.47e-01 1.36e-01 7.37e-01
LGI-ADAM interactions 14 3.78e-01 1.36e-01 8.59e-01
Uptake and actions of bacterial toxins 29 2.07e-01 1.35e-01 7.79e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 3.34e-01 1.35e-01 8.37e-01
APC-Cdc20 mediated degradation of Nek2A 26 2.34e-01 1.35e-01 7.96e-01
Pyrimidine salvage 10 4.60e-01 -1.35e-01 8.77e-01
Glycogen storage diseases 14 3.83e-01 1.35e-01 8.60e-01
SHC-mediated cascade:FGFR1 21 2.85e-01 1.35e-01 8.21e-01
RHOV GTPase cycle 36 1.63e-01 -1.34e-01 7.37e-01
TP53 Regulates Transcription of DNA Repair Genes 57 7.95e-02 1.34e-01 6.39e-01
Creation of C4 and C2 activators 14 3.84e-01 1.34e-01 8.60e-01
SUMOylation of RNA binding proteins 45 1.19e-01 -1.34e-01 7.11e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 4.62e-01 -1.34e-01 8.77e-01
Diseases of mitotic cell cycle 37 1.59e-01 1.34e-01 7.37e-01
Dermatan sulfate biosynthesis 10 4.64e-01 1.34e-01 8.77e-01
RNA Polymerase II Pre-transcription Events 73 4.85e-02 1.33e-01 5.32e-01
Signaling by FGFR2 IIIa TM 19 3.14e-01 1.33e-01 8.23e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 23 2.72e-01 1.32e-01 8.19e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 23 2.72e-01 1.32e-01 8.19e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 23 2.72e-01 1.32e-01 8.19e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 23 2.72e-01 1.32e-01 8.19e-01
Impaired BRCA2 binding to PALB2 23 2.72e-01 1.32e-01 8.19e-01
FGFR1 mutant receptor activation 30 2.10e-01 -1.32e-01 7.82e-01
FGFR1c ligand binding and activation 11 4.48e-01 1.32e-01 8.76e-01
Signaling by activated point mutants of FGFR1 11 4.48e-01 1.32e-01 8.76e-01
SHC1 events in EGFR signaling 14 3.93e-01 1.32e-01 8.64e-01
Acetylcholine binding and downstream events 14 3.95e-01 1.31e-01 8.64e-01
Postsynaptic nicotinic acetylcholine receptors 14 3.95e-01 1.31e-01 8.64e-01
Signaling by FGFR4 in disease 11 4.52e-01 1.31e-01 8.76e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 4.83e-02 1.31e-01 5.32e-01
RNA Polymerase I Transcription 47 1.21e-01 1.31e-01 7.12e-01
Phenylalanine and tyrosine metabolism 10 4.75e-01 1.31e-01 8.82e-01
G beta:gamma signalling through PLC beta 20 3.13e-01 -1.30e-01 8.23e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 2.60e-01 1.30e-01 8.19e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 15 3.84e-01 1.30e-01 8.60e-01
Fatty acids 15 3.85e-01 1.30e-01 8.60e-01
MASTL Facilitates Mitotic Progression 10 4.78e-01 1.30e-01 8.84e-01
Diseases associated with the TLR signaling cascade 29 2.28e-01 -1.29e-01 7.82e-01
Diseases of Immune System 29 2.28e-01 -1.29e-01 7.82e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 12 4.38e-01 -1.29e-01 8.76e-01
Mitophagy 27 2.46e-01 1.29e-01 8.07e-01
SUMOylation of DNA methylation proteins 16 3.73e-01 -1.29e-01 8.58e-01
mRNA Splicing 184 2.59e-03 1.29e-01 7.41e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 3.58e-01 1.29e-01 8.43e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 3.58e-01 1.29e-01 8.43e-01
Diseases associated with O-glycosylation of proteins 66 7.14e-02 1.28e-01 6.27e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 1.07e-01 1.28e-01 6.81e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 62 8.15e-02 1.28e-01 6.46e-01
Dopamine Neurotransmitter Release Cycle 20 3.23e-01 1.28e-01 8.37e-01
Listeria monocytogenes entry into host cells 19 3.36e-01 1.28e-01 8.37e-01
RHO GTPases Activate NADPH Oxidases 22 3.01e-01 -1.27e-01 8.21e-01
Eicosanoid ligand-binding receptors 14 4.10e-01 -1.27e-01 8.66e-01
B-WICH complex positively regulates rRNA expression 29 2.36e-01 1.27e-01 7.98e-01
TP53 Regulates Transcription of Cell Cycle Genes 49 1.25e-01 1.27e-01 7.22e-01
Maturation of spike protein 9694548 35 1.95e-01 -1.27e-01 7.73e-01
Export of Viral Ribonucleoproteins from Nucleus 31 2.23e-01 -1.26e-01 7.82e-01
Signaling by Non-Receptor Tyrosine Kinases 55 1.05e-01 1.26e-01 6.75e-01
Signaling by PTK6 55 1.05e-01 1.26e-01 6.75e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 14 4.14e-01 -1.26e-01 8.69e-01
Diseases of hemostasis 14 4.14e-01 -1.26e-01 8.69e-01
Regulation of KIT signaling 16 3.83e-01 -1.26e-01 8.60e-01
RNA Polymerase I Promoter Clearance 46 1.40e-01 1.26e-01 7.37e-01
Acetylcholine regulates insulin secretion 10 4.91e-01 -1.26e-01 8.92e-01
Resolution of D-Loop Structures 31 2.27e-01 1.25e-01 7.82e-01
FRS-mediated FGFR1 signaling 23 2.98e-01 1.25e-01 8.21e-01
Hh mutants abrogate ligand secretion 57 1.02e-01 1.25e-01 6.75e-01
Prolactin receptor signaling 15 4.01e-01 -1.25e-01 8.64e-01
Signaling by FGFR2 in disease 42 1.62e-01 1.25e-01 7.37e-01
SCF(Skp2)-mediated degradation of p27/p21 58 1.00e-01 1.25e-01 6.75e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 3.34e-01 1.25e-01 8.37e-01
Nuclear Pore Complex (NPC) Disassembly 34 2.08e-01 -1.25e-01 7.82e-01
Activated NOTCH1 Transmits Signal to the Nucleus 31 2.30e-01 1.25e-01 7.85e-01
Constitutive Signaling by Overexpressed ERBB2 10 4.96e-01 1.24e-01 8.92e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 58 1.02e-01 1.24e-01 6.75e-01
Miscellaneous transport and binding events 21 3.25e-01 -1.24e-01 8.37e-01
RHOH GTPase cycle 36 1.97e-01 -1.24e-01 7.73e-01
Plasma lipoprotein assembly, remodeling, and clearance 73 6.72e-02 1.24e-01 6.17e-01
Signaling by FGFR2 72 6.94e-02 1.24e-01 6.23e-01
Carnitine metabolism 11 4.79e-01 1.23e-01 8.84e-01
Non-integrin membrane-ECM interactions 40 1.77e-01 1.23e-01 7.64e-01
FOXO-mediated transcription of cell death genes 15 4.10e-01 1.23e-01 8.66e-01
Activated point mutants of FGFR2 16 3.95e-01 1.23e-01 8.64e-01
SARS-CoV-1 Infection 134 1.45e-02 1.22e-01 2.52e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 43 1.66e-01 1.22e-01 7.44e-01
Signaling by PDGFR in disease 20 3.44e-01 -1.22e-01 8.37e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 2.05e-01 1.22e-01 7.79e-01
Defensins 36 2.06e-01 -1.22e-01 7.79e-01
Transcriptional Regulation by E2F6 32 2.35e-01 -1.21e-01 7.96e-01
Interleukin-37 signaling 20 3.48e-01 -1.21e-01 8.37e-01
Metabolism of amino acids and derivatives 344 1.14e-04 1.21e-01 5.21e-03
Transcription of the HIV genome 62 1.00e-01 1.21e-01 6.75e-01
Defective CFTR causes cystic fibrosis 59 1.09e-01 1.21e-01 6.88e-01
Interleukin receptor SHC signaling 24 3.07e-01 -1.20e-01 8.23e-01
BBSome-mediated cargo-targeting to cilium 23 3.19e-01 -1.20e-01 8.29e-01
Defective C1GALT1C1 causes TNPS 18 3.78e-01 1.20e-01 8.59e-01
Cleavage of the damaged pyrimidine 16 4.07e-01 -1.20e-01 8.66e-01
Depyrimidination 16 4.07e-01 -1.20e-01 8.66e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 16 4.07e-01 -1.20e-01 8.66e-01
Signaling by EGFR 49 1.47e-01 1.20e-01 7.37e-01
Defective GALNT3 causes HFTC 18 3.80e-01 1.20e-01 8.60e-01
RAC1 GTPase cycle 170 7.14e-03 -1.20e-01 1.62e-01
Signaling by FGFR3 39 1.98e-01 1.19e-01 7.73e-01
Acyl chain remodelling of PS 21 3.45e-01 1.19e-01 8.37e-01
Epigenetic regulation of gene expression 83 6.08e-02 1.19e-01 6.01e-01
FGFR2 alternative splicing 26 2.94e-01 1.19e-01 8.21e-01
HS-GAG degradation 18 3.83e-01 1.19e-01 8.60e-01
Heparan sulfate/heparin (HS-GAG) metabolism 49 1.53e-01 1.18e-01 7.37e-01
HDL remodeling 10 5.19e-01 1.18e-01 8.95e-01
Ketone body metabolism 10 5.20e-01 -1.18e-01 8.95e-01
ABC transporter disorders 75 7.84e-02 1.18e-01 6.39e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 5.20e-01 1.17e-01 8.95e-01
RHOBTB2 GTPase cycle 22 3.41e-01 -1.17e-01 8.37e-01
Vitamin B5 (pantothenate) metabolism 16 4.17e-01 -1.17e-01 8.71e-01
Hedgehog ligand biogenesis 63 1.08e-01 1.17e-01 6.81e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 2.84e-01 1.17e-01 8.21e-01
Striated Muscle Contraction 33 2.46e-01 1.17e-01 8.07e-01
IKK complex recruitment mediated by RIP1 22 3.44e-01 -1.17e-01 8.37e-01
mRNA Capping 28 2.86e-01 1.16e-01 8.21e-01
Glycogen breakdown (glycogenolysis) 11 5.07e-01 1.16e-01 8.93e-01
FLT3 Signaling 38 2.20e-01 -1.15e-01 7.82e-01
RNA Polymerase I Transcription Initiation 42 1.98e-01 1.15e-01 7.73e-01
Apoptotic cleavage of cell adhesion proteins 11 5.11e-01 1.14e-01 8.93e-01
Calcitonin-like ligand receptors 10 5.31e-01 -1.14e-01 9.03e-01
Peroxisomal protein import 62 1.21e-01 1.14e-01 7.12e-01
Erythropoietin activates RAS 14 4.62e-01 1.14e-01 8.77e-01
Complex I biogenesis 49 1.72e-01 1.13e-01 7.57e-01
Signaling by high-kinase activity BRAF mutants 32 2.70e-01 -1.13e-01 8.19e-01
Synaptic adhesion-like molecules 19 3.96e-01 1.13e-01 8.64e-01
Metabolism of RNA 639 1.13e-06 1.13e-01 1.09e-04
Transport of bile salts and organic acids, metal ions and amine compounds 84 7.48e-02 1.12e-01 6.28e-01
Signaling by ERBB2 ECD mutants 15 4.51e-01 1.12e-01 8.76e-01
Polymerase switching on the C-strand of the telomere 24 3.42e-01 -1.12e-01 8.37e-01
Cytosolic sulfonation of small molecules 21 3.75e-01 1.12e-01 8.58e-01
G beta:gamma signalling through PI3Kgamma 25 3.33e-01 -1.12e-01 8.37e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 5.21e-01 -1.12e-01 8.96e-01
Lysosome Vesicle Biogenesis 33 2.67e-01 1.12e-01 8.19e-01
G beta:gamma signalling through CDC42 19 4.01e-01 -1.11e-01 8.64e-01
mRNA Splicing - Major Pathway 174 1.13e-02 1.11e-01 2.29e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 34 2.62e-01 1.11e-01 8.19e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 30 2.92e-01 1.11e-01 8.21e-01
Diseases of glycosylation 137 2.47e-02 1.11e-01 3.68e-01
Transport of Mature mRNA Derived from an Intronless Transcript 40 2.25e-01 -1.11e-01 7.82e-01
Late endosomal microautophagy 32 2.80e-01 1.10e-01 8.20e-01
Surfactant metabolism 28 3.13e-01 1.10e-01 8.23e-01
Dual incision in TC-NER 63 1.30e-01 1.10e-01 7.28e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 41 2.22e-01 -1.10e-01 7.82e-01
Condensation of Prophase Chromosomes 12 5.09e-01 -1.10e-01 8.93e-01
FCERI mediated MAPK activation 29 3.05e-01 -1.10e-01 8.23e-01
InlB-mediated entry of Listeria monocytogenes into host cell 14 4.76e-01 1.10e-01 8.83e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 5.28e-01 -1.10e-01 9.00e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 16 4.47e-01 1.10e-01 8.76e-01
TP53 Regulates Metabolic Genes 83 8.43e-02 1.10e-01 6.52e-01
Regulation of Complement cascade 45 2.03e-01 -1.10e-01 7.79e-01
Synthesis of bile acids and bile salts 34 2.69e-01 -1.10e-01 8.19e-01
Signaling by NTRK3 (TRKC) 17 4.36e-01 1.09e-01 8.76e-01
ROS and RNS production in phagocytes 35 2.64e-01 1.09e-01 8.19e-01
G alpha (i) signalling events 305 1.04e-03 -1.09e-01 3.92e-02
SUMOylation of SUMOylation proteins 33 2.79e-01 -1.09e-01 8.20e-01
Presynaptic depolarization and calcium channel opening 12 5.13e-01 1.09e-01 8.94e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 4.52e-01 1.09e-01 8.76e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 95 6.75e-02 1.09e-01 6.17e-01
Phase 0 - rapid depolarisation 31 2.96e-01 1.08e-01 8.21e-01
Cell surface interactions at the vascular wall 127 3.48e-02 -1.08e-01 4.38e-01
RHOBTB1 GTPase cycle 22 3.80e-01 -1.08e-01 8.60e-01
Mitochondrial iron-sulfur cluster biogenesis 12 5.18e-01 1.08e-01 8.95e-01
O-glycosylation of TSR domain-containing proteins 37 2.57e-01 1.08e-01 8.17e-01
Vitamin D (calciferol) metabolism 12 5.19e-01 -1.08e-01 8.95e-01
Processing of Capped Intron-Containing Pre-mRNA 232 4.76e-03 1.07e-01 1.21e-01
Heme signaling 45 2.12e-01 -1.07e-01 7.82e-01
Metabolism of polyamines 55 1.69e-01 1.07e-01 7.53e-01
Diseases of carbohydrate metabolism 30 3.11e-01 1.07e-01 8.23e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 20 4.09e-01 1.07e-01 8.66e-01
IL-6-type cytokine receptor ligand interactions 17 4.47e-01 1.07e-01 8.76e-01
Transport of the SLBP independent Mature mRNA 33 2.91e-01 -1.06e-01 8.21e-01
RHOG GTPase cycle 69 1.28e-01 -1.06e-01 7.28e-01
Nitric oxide stimulates guanylate cyclase 22 3.91e-01 -1.06e-01 8.64e-01
Ovarian tumor domain proteases 36 2.73e-01 -1.06e-01 8.20e-01
Cytosolic sensors of pathogen-associated DNA 60 1.57e-01 1.06e-01 7.37e-01
ABC transporters in lipid homeostasis 17 4.58e-01 1.04e-01 8.76e-01
Defective B3GALTL causes PpS 36 2.80e-01 1.04e-01 8.20e-01
The citric acid (TCA) cycle and respiratory electron transport 143 3.19e-02 1.04e-01 4.21e-01
Ubiquitin-dependent degradation of Cyclin D 50 2.05e-01 1.04e-01 7.79e-01
Attachment and Entry 9694614 16 4.74e-01 1.03e-01 8.81e-01
RNA Polymerase II Transcription Termination 62 1.59e-01 1.03e-01 7.37e-01
Plasma lipoprotein clearance 37 2.78e-01 1.03e-01 8.20e-01
Phosphorylation of the APC/C 20 4.26e-01 1.03e-01 8.76e-01
Autodegradation of Cdh1 by Cdh1:APC/C 62 1.62e-01 1.03e-01 7.37e-01
SCF-beta-TrCP mediated degradation of Emi1 53 1.96e-01 1.03e-01 7.73e-01
Adherens junctions interactions 26 3.67e-01 -1.02e-01 8.48e-01
VEGFR2 mediated cell proliferation 19 4.42e-01 1.02e-01 8.76e-01
Macroautophagy 111 6.38e-02 1.02e-01 6.05e-01
RUNX3 regulates p14-ARF 10 5.78e-01 -1.02e-01 9.23e-01
Regulation of ornithine decarboxylase (ODC) 49 2.18e-01 1.02e-01 7.82e-01
CRMPs in Sema3A signaling 15 4.96e-01 1.02e-01 8.92e-01
Oxidative Stress Induced Senescence 66 1.54e-01 -1.01e-01 7.37e-01
Binding and Uptake of Ligands by Scavenger Receptors 41 2.62e-01 -1.01e-01 8.19e-01
Deactivation of the beta-catenin transactivating complex 39 2.77e-01 1.01e-01 8.20e-01
Reproduction 82 1.16e-01 -1.00e-01 7.06e-01
Glutathione synthesis and recycling 12 5.49e-01 1.00e-01 9.14e-01
Respiratory electron transport 90 1.01e-01 9.99e-02 6.75e-01
Dectin-1 mediated noncanonical NF-kB signaling 60 1.81e-01 9.99e-02 7.64e-01
Signaling by NOTCH2 32 3.30e-01 9.95e-02 8.37e-01
Muscle contraction 193 1.72e-02 9.94e-02 2.91e-01
Signaling by MET 66 1.62e-01 9.94e-02 7.37e-01
Interferon alpha/beta signaling 69 1.54e-01 -9.93e-02 7.37e-01
Telomere C-strand (Lagging Strand) Synthesis 32 3.31e-01 -9.92e-02 8.37e-01
Keratinization 213 1.27e-02 -9.90e-02 2.38e-01
Other semaphorin interactions 18 4.68e-01 -9.88e-02 8.80e-01
The role of Nef in HIV-1 replication and disease pathogenesis 27 3.76e-01 9.85e-02 8.58e-01
NCAM signaling for neurite out-growth 57 1.98e-01 9.85e-02 7.73e-01
LDL clearance 19 4.58e-01 9.84e-02 8.76e-01
Negative regulation of NOTCH4 signaling 52 2.21e-01 9.81e-02 7.82e-01
Gluconeogenesis 32 3.38e-01 9.79e-02 8.37e-01
MET promotes cell motility 29 3.64e-01 9.75e-02 8.47e-01
PIWI-interacting RNA (piRNA) biogenesis 29 3.66e-01 9.69e-02 8.48e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 54 2.19e-01 9.66e-02 7.82e-01
Autophagy 125 6.25e-02 9.64e-02 6.03e-01
Negative epigenetic regulation of rRNA expression 45 2.65e-01 9.61e-02 8.19e-01
p53-Dependent G1 DNA Damage Response 64 1.85e-01 9.58e-02 7.67e-01
p53-Dependent G1/S DNA damage checkpoint 64 1.85e-01 9.58e-02 7.67e-01
FCGR activation 12 5.66e-01 -9.57e-02 9.18e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 38 3.07e-01 -9.57e-02 8.23e-01
Xenobiotics 24 4.17e-01 -9.57e-02 8.71e-01
Iron uptake and transport 57 2.12e-01 9.55e-02 7.82e-01
Pyroptosis 26 4.00e-01 -9.54e-02 8.64e-01
Nucleotide Excision Repair 107 8.86e-02 9.53e-02 6.68e-01
APC/C:Cdc20 mediated degradation of Securin 66 1.81e-01 9.51e-02 7.64e-01
HS-GAG biosynthesis 28 3.87e-01 9.45e-02 8.61e-01
Fanconi Anemia Pathway 36 3.27e-01 9.45e-02 8.37e-01
Nuclear Envelope Breakdown 50 2.48e-01 -9.44e-02 8.07e-01
CDK-mediated phosphorylation and removal of Cdc6 71 1.69e-01 9.44e-02 7.53e-01
Regulation of TP53 Degradation 36 3.27e-01 9.43e-02 8.37e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 41 2.97e-01 -9.41e-02 8.21e-01
VxPx cargo-targeting to cilium 20 4.67e-01 9.40e-02 8.79e-01
Interleukin-6 signaling 11 5.89e-01 -9.40e-02 9.27e-01
HIV Life Cycle 139 5.56e-02 9.40e-02 5.83e-01
Negative regulation of FLT3 15 5.29e-01 -9.39e-02 9.00e-01
Signaling by NOTCH3 48 2.62e-01 9.35e-02 8.19e-01
AKT phosphorylates targets in the cytosol 14 5.45e-01 9.33e-02 9.11e-01
Rev-mediated nuclear export of HIV RNA 33 3.54e-01 -9.33e-02 8.43e-01
Diseases of metabolism 234 1.39e-02 9.33e-02 2.47e-01
Complement cascade 56 2.29e-01 -9.30e-02 7.82e-01
Phospholipase C-mediated cascade; FGFR3 12 5.77e-01 9.29e-02 9.23e-01
Presynaptic function of Kainate receptors 21 4.62e-01 -9.26e-02 8.77e-01
MET activates PTK2 signaling 18 4.97e-01 9.25e-02 8.92e-01
Formation of apoptosome 10 6.13e-01 -9.25e-02 9.28e-01
Regulation of the apoptosome activity 10 6.13e-01 -9.25e-02 9.28e-01
NoRC negatively regulates rRNA expression 43 2.94e-01 9.25e-02 8.21e-01
Senescence-Associated Secretory Phenotype (SASP) 53 2.44e-01 9.25e-02 8.07e-01
HDR through Homologous Recombination (HRR) 64 2.01e-01 9.24e-02 7.77e-01
Advanced glycosylation endproduct receptor signaling 13 5.64e-01 9.23e-02 9.18e-01
p75 NTR receptor-mediated signalling 89 1.32e-01 9.23e-02 7.28e-01
PI-3K cascade:FGFR4 19 4.86e-01 9.23e-02 8.92e-01
Signaling by FGFR1 in disease 37 3.32e-01 -9.22e-02 8.37e-01
Adrenaline,noradrenaline inhibits insulin secretion 28 4.00e-01 9.20e-02 8.64e-01
Initiation of Nuclear Envelope (NE) Reformation 18 5.00e-01 9.17e-02 8.92e-01
RAC2 GTPase cycle 80 1.56e-01 -9.17e-02 7.37e-01
Cyclin A:Cdk2-associated events at S phase entry 83 1.49e-01 9.15e-02 7.37e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 10 6.17e-01 9.13e-02 9.28e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 21 4.70e-01 9.11e-02 8.80e-01
Nucleotide biosynthesis 14 5.55e-01 9.10e-02 9.18e-01
Signaling by NOTCH4 79 1.62e-01 9.09e-02 7.37e-01
Metabolism of non-coding RNA 50 2.66e-01 -9.08e-02 8.19e-01
snRNP Assembly 50 2.66e-01 -9.08e-02 8.19e-01
Inhibition of DNA recombination at telomere 20 4.82e-01 9.08e-02 8.87e-01
Autodegradation of the E3 ubiquitin ligase COP1 50 2.68e-01 9.06e-02 8.19e-01
Cyclin E associated events during G1/S transition 81 1.61e-01 9.00e-02 7.37e-01
Activation of gene expression by SREBF (SREBP) 42 3.13e-01 9.00e-02 8.23e-01
EPH-ephrin mediated repulsion of cells 48 2.82e-01 8.98e-02 8.20e-01
Translesion Synthesis by POLH 19 5.00e-01 8.94e-02 8.92e-01
Sensory processing of sound by inner hair cells of the cochlea 62 2.23e-01 8.94e-02 7.82e-01
Nuclear events stimulated by ALK signaling in cancer 18 5.12e-01 -8.93e-02 8.94e-01
Adenylate cyclase activating pathway 10 6.25e-01 8.92e-02 9.29e-01
Interleukin-10 signaling 45 3.01e-01 -8.92e-02 8.21e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 87 1.51e-01 8.91e-02 7.37e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 1.94e-01 8.91e-02 7.73e-01
Passive transport by Aquaporins 13 5.78e-01 8.91e-02 9.23e-01
Activation of BH3-only proteins 30 3.99e-01 8.90e-02 8.64e-01
SHC-mediated cascade:FGFR4 19 5.04e-01 8.86e-02 8.93e-01
Potassium Channels 102 1.23e-01 8.83e-02 7.20e-01
Post-chaperonin tubulin folding pathway 23 4.64e-01 -8.81e-02 8.77e-01
RHO GTPases activate KTN1 11 6.14e-01 8.79e-02 9.28e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 4.97e-01 8.77e-02 8.92e-01
ADP signalling through P2Y purinoceptor 1 25 4.48e-01 -8.77e-02 8.76e-01
Unfolded Protein Response (UPR) 90 1.51e-01 8.76e-02 7.37e-01
HDACs deacetylate histones 29 4.15e-01 8.75e-02 8.70e-01
Post-translational protein phosphorylation 100 1.31e-01 -8.73e-02 7.28e-01
Metabolism of nucleotides 95 1.43e-01 8.70e-02 7.37e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 2.79e-01 8.68e-02 8.20e-01
Unblocking of NMDA receptors, glutamate binding and activation 19 5.13e-01 -8.66e-02 8.94e-01
Scavenging by Class A Receptors 19 5.14e-01 -8.65e-02 8.94e-01
Downstream signaling of activated FGFR4 26 4.45e-01 8.65e-02 8.76e-01
PD-1 signaling 21 4.93e-01 8.64e-02 8.92e-01
Vpu mediated degradation of CD4 50 2.91e-01 8.64e-02 8.21e-01
Glycerophospholipid biosynthesis 114 1.11e-01 8.63e-02 6.96e-01
Transport of the SLBP Dependant Mature mRNA 34 3.84e-01 -8.62e-02 8.60e-01
Nuclear import of Rev protein 32 3.99e-01 -8.62e-02 8.64e-01
Signaling by ERBB2 49 2.98e-01 8.60e-02 8.21e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 4.57e-01 8.59e-02 8.76e-01
Activation of BAD and translocation to mitochondria 15 5.65e-01 8.59e-02 9.18e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 2.08e-01 8.59e-02 7.81e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 3.60e-01 8.58e-02 8.43e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 20 5.06e-01 -8.58e-02 8.93e-01
Homology Directed Repair 99 1.40e-01 8.58e-02 7.37e-01
CS/DS degradation 12 6.08e-01 8.54e-02 9.28e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 3.01e-01 8.53e-02 8.21e-01
Axon guidance 503 1.07e-03 8.51e-02 3.94e-02
RNA Polymerase I Promoter Escape 28 4.36e-01 8.50e-02 8.76e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 12 6.11e-01 8.47e-02 9.28e-01
Defective EXT2 causes exostoses 2 12 6.11e-01 8.47e-02 9.28e-01
Nervous system development 527 8.64e-04 8.47e-02 3.34e-02
Aspartate and asparagine metabolism 11 6.29e-01 -8.41e-02 9.29e-01
Chaperone Mediated Autophagy 19 5.26e-01 8.41e-02 8.99e-01
G1/S DNA Damage Checkpoints 66 2.37e-01 8.41e-02 7.98e-01
Sodium/Calcium exchangers 11 6.30e-01 -8.38e-02 9.30e-01
PINK1-PRKN Mediated Mitophagy 21 5.07e-01 8.36e-02 8.93e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 74 2.14e-01 8.35e-02 7.82e-01
Phase I - Functionalization of compounds 100 1.50e-01 8.32e-02 7.37e-01
Endosomal/Vacuolar pathway 12 6.18e-01 8.31e-02 9.28e-01
Insulin processing 26 4.63e-01 -8.31e-02 8.77e-01
Frs2-mediated activation 12 6.19e-01 8.30e-02 9.28e-01
Metabolism of porphyrins 27 4.55e-01 -8.30e-02 8.76e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 6.04e-01 8.30e-02 9.28e-01
DNA Double-Strand Break Repair 129 1.04e-01 8.30e-02 6.75e-01
FRS-mediated FGFR4 signaling 21 5.11e-01 8.29e-02 8.93e-01
G0 and Early G1 27 4.56e-01 8.29e-02 8.76e-01
Translocation of ZAP-70 to Immunological synapse 17 5.55e-01 8.26e-02 9.18e-01
HIV Transcription Initiation 43 3.50e-01 8.24e-02 8.37e-01
RNA Polymerase II HIV Promoter Escape 43 3.50e-01 8.24e-02 8.37e-01
RNA Polymerase II Promoter Escape 43 3.50e-01 8.24e-02 8.37e-01
RNA Polymerase II Transcription Initiation 43 3.50e-01 8.24e-02 8.37e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 43 3.50e-01 8.24e-02 8.37e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 43 3.50e-01 8.24e-02 8.37e-01
Endogenous sterols 26 4.70e-01 8.19e-02 8.80e-01
G-protein beta:gamma signalling 30 4.37e-01 -8.19e-02 8.76e-01
Chondroitin sulfate/dermatan sulfate metabolism 45 3.43e-01 8.17e-02 8.37e-01
Meiosis 56 2.91e-01 -8.16e-02 8.21e-01
Suppression of phagosomal maturation 13 6.11e-01 8.15e-02 9.28e-01
Beta defensins 28 4.56e-01 -8.14e-02 8.76e-01
TICAM1-dependent activation of IRF3/IRF7 12 6.26e-01 8.13e-02 9.29e-01
G-protein activation 24 4.91e-01 -8.13e-02 8.92e-01
Potential therapeutics for SARS 92 1.78e-01 8.13e-02 7.64e-01
NIK–>noncanonical NF-kB signaling 57 2.89e-01 8.11e-02 8.21e-01
Regulation of TNFR1 signaling 37 3.94e-01 8.10e-02 8.64e-01
PECAM1 interactions 12 6.28e-01 -8.09e-02 9.29e-01
TNF signaling 45 3.48e-01 8.08e-02 8.37e-01
Regulation of APC/C activators between G1/S and early anaphase 79 2.14e-01 8.08e-02 7.82e-01
Cardiac conduction 123 1.22e-01 8.08e-02 7.12e-01
Late Phase of HIV Life Cycle 126 1.17e-01 8.08e-02 7.06e-01
Nicotinamide salvaging 17 5.66e-01 8.05e-02 9.18e-01
Neutrophil degranulation 458 3.20e-03 -8.02e-02 8.38e-02
Activation of the phototransduction cascade 11 6.46e-01 8.01e-02 9.42e-01
Thromboxane signalling through TP receptor 24 4.97e-01 -8.00e-02 8.92e-01
RNA polymerase II transcribes snRNA genes 77 2.25e-01 8.00e-02 7.82e-01
Integration of energy metabolism 106 1.55e-01 7.99e-02 7.37e-01
Semaphorin interactions 61 2.81e-01 7.98e-02 8.20e-01
Synthesis, secretion, and deacylation of Ghrelin 19 5.47e-01 7.98e-02 9.12e-01
Cell death signalling via NRAGE, NRIF and NADE 69 2.53e-01 7.96e-02 8.14e-01
Presynaptic nicotinic acetylcholine receptors 12 6.33e-01 7.96e-02 9.31e-01
Regulation of TP53 Expression and Degradation 37 4.03e-01 7.94e-02 8.66e-01
Acetylcholine Neurotransmitter Release Cycle 16 5.83e-01 7.93e-02 9.25e-01
Glycogen metabolism 22 5.20e-01 7.93e-02 8.95e-01
Processing of Capped Intronless Pre-mRNA 28 4.69e-01 7.91e-02 8.80e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 24 5.02e-01 -7.91e-02 8.92e-01
Visual phototransduction 93 1.88e-01 7.90e-02 7.71e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 3.45e-01 7.88e-02 8.37e-01
Homologous DNA Pairing and Strand Exchange 41 3.84e-01 7.86e-02 8.60e-01
Crosslinking of collagen fibrils 10 6.67e-01 7.86e-02 9.50e-01
Protein methylation 16 5.90e-01 -7.79e-02 9.27e-01
Organic cation/anion/zwitterion transport 15 6.04e-01 7.74e-02 9.28e-01
Signaling by Activin 15 6.04e-01 7.74e-02 9.28e-01
Mucopolysaccharidoses 10 6.72e-01 7.73e-02 9.51e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 29 4.72e-01 7.72e-02 8.80e-01
Trafficking of AMPA receptors 29 4.72e-01 7.72e-02 8.80e-01
mRNA 3’-end processing 53 3.31e-01 7.71e-02 8.37e-01
Interleukin-7 signaling 21 5.41e-01 -7.71e-02 9.11e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 16 5.93e-01 7.71e-02 9.28e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 5.44e-01 7.65e-02 9.11e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 5.44e-01 7.65e-02 9.11e-01
Activation of NF-kappaB in B cells 64 2.91e-01 7.63e-02 8.21e-01
Adenylate cyclase inhibitory pathway 14 6.21e-01 7.63e-02 9.28e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 2.55e-01 7.60e-02 8.14e-01
PKMTs methylate histone lysines 37 4.25e-01 -7.58e-02 8.76e-01
FGFR2c ligand binding and activation 12 6.50e-01 7.57e-02 9.43e-01
Azathioprine ADME 22 5.40e-01 7.55e-02 9.11e-01
Intraflagellar transport 36 4.33e-01 -7.55e-02 8.76e-01
Keratan sulfate/keratin metabolism 33 4.54e-01 -7.53e-02 8.76e-01
RHOBTB GTPase Cycle 34 4.48e-01 -7.51e-02 8.76e-01
Mitochondrial protein import 54 3.40e-01 -7.51e-02 8.37e-01
HIV Infection 216 5.74e-02 7.50e-02 5.83e-01
PI-3K cascade:FGFR2 22 5.44e-01 7.47e-02 9.11e-01
EPHA-mediated growth cone collapse 15 6.17e-01 7.45e-02 9.28e-01
Peptide hormone biosynthesis 11 6.70e-01 7.43e-02 9.50e-01
Drug ADME 104 1.92e-01 -7.41e-02 7.71e-01
PTEN Regulation 150 1.17e-01 7.40e-02 7.06e-01
Regulation of BACH1 activity 15 6.20e-01 7.39e-02 9.28e-01
Downstream signaling of activated FGFR2 29 4.92e-01 7.37e-02 8.92e-01
SUMOylation of transcription factors 20 5.69e-01 7.35e-02 9.18e-01
Signalling to RAS 20 5.70e-01 7.34e-02 9.18e-01
Molecules associated with elastic fibres 29 4.94e-01 7.34e-02 8.92e-01
Base-Excision Repair, AP Site Formation 18 5.90e-01 -7.34e-02 9.27e-01
RHOJ GTPase cycle 51 3.65e-01 -7.33e-02 8.48e-01
FCGR3A-mediated IL10 synthesis 37 4.40e-01 -7.33e-02 8.76e-01
Transcriptional Regulation by TP53 346 1.91e-02 7.32e-02 3.10e-01
Regulation of insulin secretion 77 2.67e-01 7.32e-02 8.19e-01
Activation of SMO 17 6.03e-01 -7.29e-02 9.28e-01
Killing mechanisms 11 6.75e-01 -7.29e-02 9.51e-01
WNT5:FZD7-mediated leishmania damping 11 6.75e-01 -7.29e-02 9.51e-01
Regulation of RUNX3 expression and activity 53 3.59e-01 7.28e-02 8.43e-01
Downstream signaling events of B Cell Receptor (BCR) 78 2.68e-01 7.26e-02 8.19e-01
Assembly of the ORC complex at the origin of replication 10 6.91e-01 -7.25e-02 9.56e-01
Regulation of TP53 Activity through Phosphorylation 88 2.40e-01 7.25e-02 8.03e-01
Sensory processing of sound 69 3.00e-01 7.21e-02 8.21e-01
Metabolic disorders of biological oxidation enzymes 32 4.81e-01 7.20e-02 8.86e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 12 6.66e-01 7.20e-02 9.49e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 2.92e-01 7.18e-02 8.21e-01
Resolution of Abasic Sites (AP sites) 37 4.50e-01 7.17e-02 8.76e-01
Telomere Extension By Telomerase 22 5.60e-01 -7.17e-02 9.18e-01
Interactions of Rev with host cellular proteins 35 4.63e-01 -7.17e-02 8.77e-01
SHC-mediated cascade:FGFR2 22 5.61e-01 7.16e-02 9.18e-01
Processive synthesis on the C-strand of the telomere 19 5.90e-01 -7.13e-02 9.27e-01
CDC42 GTPase cycle 143 1.41e-01 -7.12e-02 7.37e-01
RORA activates gene expression 17 6.13e-01 -7.09e-02 9.28e-01
FGFR2 ligand binding and activation 19 5.93e-01 7.09e-02 9.28e-01
Interleukin-1 signaling 109 2.03e-01 7.06e-02 7.79e-01
MyD88 cascade initiated on plasma membrane 91 2.45e-01 7.04e-02 8.07e-01
Toll Like Receptor 10 (TLR10) Cascade 91 2.45e-01 7.04e-02 8.07e-01
Toll Like Receptor 5 (TLR5) Cascade 91 2.45e-01 7.04e-02 8.07e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 39 4.47e-01 7.04e-02 8.76e-01
Diseases of DNA Double-Strand Break Repair 39 4.47e-01 7.04e-02 8.76e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 14 6.48e-01 -7.04e-02 9.42e-01
Dectin-2 family 28 5.20e-01 -7.03e-02 8.95e-01
RHO GTPases activate IQGAPs 11 6.88e-01 7.00e-02 9.56e-01
PLC beta mediated events 47 4.07e-01 -6.99e-02 8.66e-01
RIP-mediated NFkB activation via ZBP1 16 6.29e-01 6.97e-02 9.29e-01
GPCR ligand binding 443 1.19e-02 -6.96e-02 2.30e-01
Cargo recognition for clathrin-mediated endocytosis 98 2.34e-01 6.95e-02 7.96e-01
Glycogen synthesis 13 6.65e-01 6.94e-02 9.49e-01
Ca-dependent events 35 4.79e-01 -6.92e-02 8.84e-01
Thrombin signalling through proteinase activated receptors (PARs) 32 4.99e-01 -6.90e-02 8.92e-01
RNA Polymerase III Abortive And Retractive Initiation 41 4.44e-01 6.90e-02 8.76e-01
RNA Polymerase III Transcription 41 4.44e-01 6.90e-02 8.76e-01
GABA synthesis, release, reuptake and degradation 19 6.03e-01 6.89e-02 9.28e-01
CLEC7A (Dectin-1) induces NFAT activation 11 6.93e-01 -6.87e-02 9.56e-01
Diseases of programmed cell death 43 4.36e-01 -6.87e-02 8.76e-01
Basigin interactions 24 5.62e-01 6.84e-02 9.18e-01
Regulation of RAS by GAPs 65 3.42e-01 6.81e-02 8.37e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 37 4.74e-01 -6.81e-02 8.81e-01
Signal amplification 33 4.99e-01 -6.80e-02 8.92e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 12 6.83e-01 -6.80e-02 9.54e-01
FRS-mediated FGFR2 signaling 24 5.64e-01 6.80e-02 9.18e-01
Global Genome Nucleotide Excision Repair (GG-NER) 81 2.90e-01 6.79e-02 8.21e-01
Regulation of TP53 Activity through Acetylation 29 5.28e-01 6.77e-02 9.00e-01
Gap junction trafficking 27 5.43e-01 -6.76e-02 9.11e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 93 2.61e-01 6.75e-02 8.19e-01
Signalling to ERKs 34 4.97e-01 6.73e-02 8.92e-01
CLEC7A (Dectin-1) signaling 96 2.55e-01 6.71e-02 8.14e-01
Prostacyclin signalling through prostacyclin receptor 19 6.13e-01 -6.71e-02 9.28e-01
Activation of the TFAP2 (AP-2) family of transcription factors 11 7.01e-01 -6.70e-02 9.59e-01
Ethanol oxidation 12 6.89e-01 6.68e-02 9.56e-01
Regulation of PTEN gene transcription 59 3.76e-01 6.67e-02 8.58e-01
Deadenylation of mRNA 25 5.64e-01 -6.67e-02 9.18e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 51 4.10e-01 6.66e-02 8.66e-01
Constitutive Signaling by EGFRvIII 15 6.55e-01 6.66e-02 9.47e-01
Signaling by EGFRvIII in Cancer 15 6.55e-01 6.66e-02 9.47e-01
Retrograde transport at the Trans-Golgi-Network 47 4.31e-01 -6.64e-02 8.76e-01
Activation of kainate receptors upon glutamate binding 29 5.37e-01 -6.62e-02 9.10e-01
DNA Damage Bypass 46 4.38e-01 6.61e-02 8.76e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 6.94e-01 6.57e-02 9.56e-01
Phase II - Conjugation of compounds 106 2.43e-01 -6.56e-02 8.07e-01
RAF activation 33 5.15e-01 6.55e-02 8.95e-01
Termination of O-glycan biosynthesis 25 5.73e-01 6.51e-02 9.21e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 14 6.73e-01 6.51e-02 9.51e-01
Activation of the pre-replicative complex 31 5.32e-01 -6.48e-02 9.03e-01
Anti-inflammatory response favouring Leishmania parasite infection 75 3.34e-01 -6.45e-02 8.37e-01
Leishmania parasite growth and survival 75 3.34e-01 -6.45e-02 8.37e-01
UCH proteinases 81 3.16e-01 6.44e-02 8.26e-01
Ephrin signaling 17 6.46e-01 6.43e-02 9.42e-01
SHC1 events in ERBB4 signaling 14 6.77e-01 -6.42e-02 9.51e-01
ADORA2B mediated anti-inflammatory cytokines production 42 4.72e-01 -6.42e-02 8.80e-01
WNT ligand biogenesis and trafficking 25 5.81e-01 6.38e-02 9.24e-01
Signaling by ALK fusions and activated point mutants 51 4.31e-01 -6.37e-02 8.76e-01
Signaling by ALK in cancer 51 4.31e-01 -6.37e-02 8.76e-01
Regulation of Apoptosis 51 4.32e-01 6.36e-02 8.76e-01
Recognition of DNA damage by PCNA-containing replication complex 29 5.53e-01 6.36e-02 9.18e-01
Digestion and absorption 23 5.99e-01 -6.33e-02 9.28e-01
Serotonin receptors 11 7.16e-01 6.33e-02 9.66e-01
Cellular responses to stress 682 4.75e-03 6.33e-02 1.21e-01
Degradation of DVL 55 4.17e-01 6.33e-02 8.71e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 54 4.23e-01 6.31e-02 8.76e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 54 4.23e-01 6.31e-02 8.76e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 54 4.23e-01 6.31e-02 8.76e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 54 4.23e-01 6.31e-02 8.76e-01
Signaling by NOTCH1 in Cancer 54 4.23e-01 6.31e-02 8.76e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 4.41e-01 6.30e-02 8.76e-01
p53-Independent DNA Damage Response 50 4.41e-01 6.30e-02 8.76e-01
p53-Independent G1/S DNA damage checkpoint 50 4.41e-01 6.30e-02 8.76e-01
NR1H2 and NR1H3-mediated signaling 53 4.29e-01 6.28e-02 8.76e-01
Amino acid transport across the plasma membrane 30 5.52e-01 6.28e-02 9.16e-01
Termination of translesion DNA synthesis 31 5.46e-01 6.27e-02 9.11e-01
Hemostasis 555 1.15e-02 -6.26e-02 2.29e-01
Sema3A PAK dependent Axon repulsion 14 6.85e-01 6.25e-02 9.56e-01
Signaling by FGFR3 in disease 21 6.20e-01 6.25e-02 9.28e-01
Signaling by PDGFRA extracellular domain mutants 12 7.08e-01 -6.25e-02 9.60e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 7.08e-01 -6.25e-02 9.60e-01
Platelet activation, signaling and aggregation 245 9.24e-02 -6.24e-02 6.73e-01
Regulation of TP53 Activity 154 1.82e-01 6.23e-02 7.64e-01
Signaling by NTRK2 (TRKB) 25 5.90e-01 6.22e-02 9.27e-01
Regulation of PLK1 Activity at G2/M Transition 83 3.28e-01 6.21e-02 8.37e-01
Signaling by BRAF and RAF1 fusions 60 4.05e-01 -6.21e-02 8.66e-01
Cellular responses to stimuli 696 5.25e-03 6.19e-02 1.29e-01
Regulation of MECP2 expression and activity 30 5.58e-01 -6.19e-02 9.18e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 117 2.48e-01 -6.18e-02 8.07e-01
Protein-protein interactions at synapses 78 3.45e-01 6.18e-02 8.37e-01
EPH-Ephrin signaling 90 3.11e-01 6.18e-02 8.23e-01
MAPK6/MAPK4 signaling 89 3.14e-01 6.18e-02 8.23e-01
Vif-mediated degradation of APOBEC3G 50 4.50e-01 6.17e-02 8.76e-01
DARPP-32 events 24 6.02e-01 6.16e-02 9.28e-01
Removal of the Flap Intermediate from the C-strand 17 6.61e-01 -6.14e-02 9.49e-01
Metabolism of carbohydrates 275 7.95e-02 6.14e-02 6.39e-01
Free fatty acids regulate insulin secretion 10 7.38e-01 6.10e-02 9.66e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 5.38e-01 6.10e-02 9.10e-01
Estrogen-dependent gene expression 91 3.15e-01 6.10e-02 8.23e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 5.01e-01 -6.07e-02 8.92e-01
Signaling by RAS mutants 41 5.01e-01 -6.07e-02 8.92e-01
Signaling by moderate kinase activity BRAF mutants 41 5.01e-01 -6.07e-02 8.92e-01
Signaling downstream of RAS mutants 41 5.01e-01 -6.07e-02 8.92e-01
SUMO E3 ligases SUMOylate target proteins 158 1.92e-01 -6.02e-02 7.71e-01
E3 ubiquitin ligases ubiquitinate target proteins 43 4.95e-01 -6.01e-02 8.92e-01
G-protein mediated events 52 4.55e-01 -5.99e-02 8.76e-01
Recycling pathway of L1 23 6.20e-01 -5.97e-02 9.28e-01
Regulation of actin dynamics for phagocytic cup formation 59 4.30e-01 5.94e-02 8.76e-01
Protein folding 96 3.14e-01 -5.94e-02 8.23e-01
SUMOylation 164 1.89e-01 -5.94e-02 7.71e-01
Phosphorylation of CD3 and TCR zeta chains 20 6.46e-01 -5.94e-02 9.42e-01
FGFR3 mutant receptor activation 11 7.34e-01 5.93e-02 9.66e-01
Signaling by activated point mutants of FGFR3 11 7.34e-01 5.93e-02 9.66e-01
Factors involved in megakaryocyte development and platelet production 128 2.48e-01 -5.91e-02 8.07e-01
GPCR downstream signalling 603 1.31e-02 -5.90e-02 2.39e-01
RHO GTPases Activate Formins 114 2.77e-01 5.89e-02 8.20e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 7.04e-01 5.87e-02 9.60e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 6.75e-01 5.87e-02 9.51e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 5.99e-01 5.85e-02 9.28e-01
Synthesis of PIPs at the Golgi membrane 17 6.77e-01 -5.84e-02 9.51e-01
Trafficking of GluR2-containing AMPA receptors 15 6.95e-01 5.84e-02 9.56e-01
TRP channels 24 6.21e-01 5.83e-02 9.28e-01
Trafficking and processing of endosomal TLR 11 7.38e-01 5.83e-02 9.66e-01
G1/S Transition 126 2.60e-01 5.81e-02 8.19e-01
Translesion synthesis by POLI 17 6.79e-01 5.81e-02 9.51e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 6.81e-01 5.75e-02 9.53e-01
Cellular response to heat stress 95 3.33e-01 5.74e-02 8.37e-01
RHO GTPase Effectors 232 1.32e-01 5.74e-02 7.28e-01
Activated NTRK2 signals through FRS2 and FRS3 11 7.42e-01 5.72e-02 9.66e-01
Class I peroxisomal membrane protein import 19 6.66e-01 5.71e-02 9.49e-01
Elastic fibre formation 40 5.33e-01 5.70e-02 9.03e-01
SLC-mediated transmembrane transport 238 1.29e-01 5.70e-02 7.28e-01
DNA Damage/Telomere Stress Induced Senescence 28 6.02e-01 -5.69e-02 9.28e-01
Innate Immune System 999 2.28e-03 -5.69e-02 6.76e-02
Immune System 1870 4.26e-05 -5.67e-02 2.06e-03
activated TAK1 mediates p38 MAPK activation 16 6.95e-01 5.65e-02 9.56e-01
Cellular Senescence 130 2.67e-01 -5.63e-02 8.19e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 7.47e-01 -5.61e-02 9.66e-01
Adaptive Immune System 709 1.08e-02 -5.60e-02 2.23e-01
E2F mediated regulation of DNA replication 20 6.65e-01 5.60e-02 9.49e-01
RAC3 GTPase cycle 84 3.76e-01 -5.58e-02 8.58e-01
Metabolism 1963 4.12e-05 5.56e-02 2.05e-03
TNFR1-induced NFkappaB signaling pathway 22 6.53e-01 5.54e-02 9.45e-01
Stabilization of p53 55 4.78e-01 5.53e-02 8.84e-01
Signaling by RAF1 mutants 37 5.61e-01 -5.52e-02 9.18e-01
Chaperonin-mediated protein folding 90 3.66e-01 -5.52e-02 8.48e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 27 6.20e-01 5.51e-02 9.28e-01
Synthesis of IP3 and IP4 in the cytosol 25 6.34e-01 5.51e-02 9.31e-01
Synthesis of PIPs at the plasma membrane 48 5.10e-01 -5.49e-02 8.93e-01
ERBB2 Activates PTK6 Signaling 13 7.32e-01 5.49e-02 9.66e-01
TNFR2 non-canonical NF-kB pathway 94 3.57e-01 5.49e-02 8.43e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 38 5.59e-01 -5.47e-02 9.18e-01
SHC1 events in ERBB2 signaling 22 6.59e-01 -5.44e-02 9.49e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 50 5.08e-01 5.42e-02 8.93e-01
NGF-stimulated transcription 39 5.59e-01 -5.41e-02 9.18e-01
Peptide hormone metabolism 83 3.95e-01 -5.40e-02 8.64e-01
ALK mutants bind TKIs 12 7.47e-01 -5.38e-02 9.66e-01
ABC-family proteins mediated transport 98 3.59e-01 5.36e-02 8.43e-01
TICAM1, RIP1-mediated IKK complex recruitment 18 6.94e-01 5.36e-02 9.56e-01
Death Receptor Signalling 134 2.85e-01 5.34e-02 8.21e-01
DAG and IP3 signaling 39 5.65e-01 -5.32e-02 9.18e-01
PKA activation in glucagon signalling 17 7.05e-01 5.30e-02 9.60e-01
Signaling by NOTCH 183 2.16e-01 5.29e-02 7.82e-01
Activation of G protein gated Potassium channels 29 6.22e-01 -5.29e-02 9.28e-01
G protein gated Potassium channels 29 6.22e-01 -5.29e-02 9.28e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 29 6.22e-01 -5.29e-02 9.28e-01
Regulation of signaling by CBL 18 6.99e-01 -5.27e-02 9.58e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 6.18e-01 -5.26e-02 9.28e-01
Signaling by Insulin receptor 77 4.25e-01 5.26e-02 8.76e-01
G2/M Checkpoints 129 3.02e-01 5.26e-02 8.21e-01
Signaling by GPCR 670 2.04e-02 -5.24e-02 3.19e-01
Formation of the cornified envelope 73 4.39e-01 5.23e-02 8.76e-01
Neddylation 228 1.73e-01 5.23e-02 7.58e-01
Switching of origins to a post-replicative state 90 3.92e-01 5.21e-02 8.64e-01
Dual Incision in GG-NER 39 5.73e-01 5.21e-02 9.21e-01
VEGFR2 mediated vascular permeability 26 6.48e-01 5.18e-02 9.42e-01
DCC mediated attractive signaling 14 7.38e-01 -5.17e-02 9.66e-01
HCMV Early Events 55 5.08e-01 -5.16e-02 8.93e-01
Transcriptional regulation of pluripotent stem cells 30 6.25e-01 5.16e-02 9.29e-01
TGF-beta receptor signaling activates SMADs 45 5.49e-01 5.16e-02 9.14e-01
PKA-mediated phosphorylation of CREB 19 6.98e-01 -5.14e-02 9.58e-01
Mitotic G1 phase and G1/S transition 144 2.87e-01 5.14e-02 8.21e-01
Clathrin-mediated endocytosis 135 3.03e-01 5.13e-02 8.21e-01
Pyruvate metabolism 29 6.34e-01 5.10e-02 9.32e-01
Cellular response to hypoxia 71 4.58e-01 5.09e-02 8.76e-01
Metabolism of steroids 148 2.86e-01 -5.08e-02 8.21e-01
APC truncation mutants have impaired AXIN binding 13 7.51e-01 5.08e-02 9.66e-01
AXIN missense mutants destabilize the destruction complex 13 7.51e-01 5.08e-02 9.66e-01
Signaling by AMER1 mutants 13 7.51e-01 5.08e-02 9.66e-01
Signaling by APC mutants 13 7.51e-01 5.08e-02 9.66e-01
Signaling by AXIN mutants 13 7.51e-01 5.08e-02 9.66e-01
Truncations of AMER1 destabilize the destruction complex 13 7.51e-01 5.08e-02 9.66e-01
Tryptophan catabolism 12 7.61e-01 -5.07e-02 9.68e-01
Cyclin A/B1/B2 associated events during G2/M transition 24 6.69e-01 5.04e-02 9.50e-01
Nucleotide salvage 21 6.91e-01 -5.01e-02 9.56e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 7.46e-01 -5.00e-02 9.66e-01
Signaling by TGF-beta Receptor Complex 90 4.13e-01 5.00e-02 8.69e-01
Stimuli-sensing channels 96 3.97e-01 5.00e-02 8.64e-01
Class A/1 (Rhodopsin-like receptors) 311 1.30e-01 -4.98e-02 7.28e-01
Mitotic Prophase 78 4.47e-01 -4.98e-02 8.76e-01
Effects of PIP2 hydrolysis 26 6.61e-01 -4.97e-02 9.49e-01
IRF3-mediated induction of type I IFN 11 7.76e-01 -4.95e-02 9.73e-01
Protein localization 147 3.00e-01 4.95e-02 8.21e-01
Signaling by ERBB2 in Cancer 25 6.70e-01 4.93e-02 9.50e-01
FCERI mediated NF-kB activation 74 4.64e-01 4.93e-02 8.77e-01
Miscellaneous substrates 12 7.68e-01 4.91e-02 9.70e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 15 7.42e-01 -4.91e-02 9.66e-01
Maturation of nucleoprotein 9694631 15 7.43e-01 4.90e-02 9.66e-01
Generation of second messenger molecules 30 6.42e-01 -4.90e-02 9.40e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 35 6.16e-01 4.89e-02 9.28e-01
Signaling by ERBB2 KD Mutants 24 6.78e-01 4.89e-02 9.51e-01
Deposition of new CENPA-containing nucleosomes at the centromere 26 6.66e-01 -4.89e-02 9.49e-01
Nucleosome assembly 26 6.66e-01 -4.89e-02 9.49e-01
Cross-presentation of soluble exogenous antigens (endosomes) 46 5.67e-01 4.88e-02 9.18e-01
Assembly of the pre-replicative complex 82 4.45e-01 4.88e-02 8.76e-01
Ion channel transport 168 2.77e-01 4.86e-02 8.20e-01
Syndecan interactions 19 7.14e-01 4.86e-02 9.66e-01
APC/C-mediated degradation of cell cycle proteins 86 4.37e-01 4.85e-02 8.76e-01
Regulation of mitotic cell cycle 86 4.37e-01 4.85e-02 8.76e-01
Netrin-1 signaling 49 5.58e-01 -4.83e-02 9.18e-01
ERK/MAPK targets 20 7.09e-01 4.82e-02 9.60e-01
Degradation of the extracellular matrix 108 3.86e-01 4.82e-02 8.61e-01
Toll-like Receptor Cascades 154 3.03e-01 -4.80e-02 8.21e-01
DNA Repair 276 1.69e-01 4.80e-02 7.53e-01
Extracellular matrix organization 287 1.61e-01 4.80e-02 7.37e-01
DNA Replication 125 3.54e-01 4.79e-02 8.43e-01
Activation of the AP-1 family of transcription factors 10 7.94e-01 4.78e-02 9.77e-01
ESR-mediated signaling 160 2.97e-01 4.78e-02 8.21e-01
Long-term potentiation 22 6.98e-01 -4.77e-02 9.58e-01
Collagen formation 88 4.42e-01 4.74e-02 8.76e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 7.51e-01 4.73e-02 9.66e-01
Reduction of cytosolic Ca++ levels 11 7.86e-01 4.73e-02 9.75e-01
Cell Cycle Checkpoints 248 2.00e-01 4.72e-02 7.74e-01
Nuclear Receptor transcription pathway 51 5.60e-01 -4.72e-02 9.18e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 7.61e-01 -4.69e-02 9.68e-01
Processing of DNA double-strand break ends 61 5.28e-01 4.68e-02 9.00e-01
Digestion 18 7.32e-01 -4.66e-02 9.66e-01
G alpha (q) signalling events 206 2.49e-01 -4.66e-02 8.07e-01
COPII-mediated vesicle transport 66 5.13e-01 4.65e-02 8.94e-01
DNA Double Strand Break Response 42 6.02e-01 4.65e-02 9.28e-01
Pentose phosphate pathway 12 7.81e-01 -4.64e-02 9.74e-01
Vasopressin regulates renal water homeostasis via Aquaporins 42 6.03e-01 -4.63e-02 9.28e-01
Toll Like Receptor 4 (TLR4) Cascade 135 3.53e-01 -4.62e-02 8.43e-01
RHO GTPase cycle 420 1.05e-01 -4.61e-02 6.75e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 7.65e-01 -4.61e-02 9.70e-01
Extension of Telomeres 48 5.81e-01 -4.61e-02 9.24e-01
RNA Polymerase II Transcription 1284 5.43e-03 4.60e-02 1.29e-01
Hedgehog ‘on’ state 83 4.70e-01 4.59e-02 8.80e-01
Early SARS-CoV-2 Infection Events 34 6.43e-01 4.59e-02 9.40e-01
Amine ligand-binding receptors 41 6.12e-01 -4.58e-02 9.28e-01
Purine ribonucleoside monophosphate biosynthesis 11 7.93e-01 -4.58e-02 9.77e-01
Signaling by Hippo 19 7.30e-01 4.57e-02 9.66e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 42 6.08e-01 -4.57e-02 9.28e-01
Oncogenic MAPK signaling 76 4.91e-01 -4.57e-02 8.92e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 15 7.60e-01 -4.56e-02 9.68e-01
Generic Transcription Pathway 1163 8.60e-03 4.55e-02 1.82e-01
Neuronal System 371 1.32e-01 4.55e-02 7.28e-01
Negative regulation of MET activity 20 7.25e-01 4.55e-02 9.66e-01
PCP/CE pathway 90 4.57e-01 4.54e-02 8.76e-01
Cell recruitment (pro-inflammatory response) 25 6.95e-01 -4.53e-02 9.56e-01
Purinergic signaling in leishmaniasis infection 25 6.95e-01 -4.53e-02 9.56e-01
Translation of Structural Proteins 9694635 55 5.61e-01 -4.53e-02 9.18e-01
Regulation of TP53 Activity through Methylation 18 7.39e-01 4.53e-02 9.66e-01
Degradation of GLI2 by the proteasome 58 5.51e-01 4.53e-02 9.16e-01
RAB GEFs exchange GTP for GDP on RABs 82 4.80e-01 -4.51e-02 8.85e-01
Synthesis of DNA 118 3.99e-01 4.49e-02 8.64e-01
Regulated Necrosis 53 5.76e-01 -4.44e-02 9.23e-01
Reversible hydration of carbon dioxide 11 7.99e-01 -4.43e-02 9.80e-01
SUMOylation of DNA replication proteins 44 6.11e-01 -4.43e-02 9.28e-01
Phospholipid metabolism 192 2.90e-01 4.43e-02 8.21e-01
Sialic acid metabolism 33 6.60e-01 -4.42e-02 9.49e-01
Gene expression (Transcription) 1420 5.19e-03 4.41e-02 1.29e-01
Transport of small molecules 689 4.84e-02 4.40e-02 5.32e-01
Glutathione conjugation 36 6.48e-01 4.40e-02 9.42e-01
Transcriptional regulation by RUNX3 93 4.63e-01 4.40e-02 8.77e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 41 6.27e-01 4.39e-02 9.29e-01
Signaling by VEGF 101 4.46e-01 4.39e-02 8.76e-01
Nucleotide-like (purinergic) receptors 13 7.86e-01 4.36e-02 9.75e-01
Bicarbonate transporters 10 8.12e-01 4.35e-02 9.83e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 5.84e-01 4.34e-02 9.26e-01
O-linked glycosylation 107 4.39e-01 4.33e-02 8.76e-01
Amyloid fiber formation 53 5.86e-01 4.33e-02 9.27e-01
Asparagine N-linked glycosylation 278 2.16e-01 4.30e-02 7.82e-01
Polo-like kinase mediated events 16 7.66e-01 -4.30e-02 9.70e-01
PIP3 activates AKT signaling 275 2.20e-01 4.29e-02 7.82e-01
Inactivation of CSF3 (G-CSF) signaling 23 7.23e-01 4.27e-02 9.66e-01
PI3K events in ERBB4 signaling 10 8.16e-01 -4.26e-02 9.83e-01
Deubiquitination 226 2.71e-01 -4.24e-02 8.19e-01
Metabolism of vitamins and cofactors 181 3.27e-01 4.22e-02 8.37e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 7.77e-01 4.22e-02 9.74e-01
Regulation of lipid metabolism by PPARalpha 116 4.33e-01 4.22e-02 8.76e-01
Collagen biosynthesis and modifying enzymes 65 5.57e-01 4.21e-02 9.18e-01
Disorders of transmembrane transporters 167 3.47e-01 4.21e-02 8.37e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 21 7.39e-01 4.21e-02 9.66e-01
Glycosaminoglycan metabolism 116 4.34e-01 4.20e-02 8.76e-01
RND1 GTPase cycle 41 6.42e-01 4.19e-02 9.40e-01
Presynaptic phase of homologous DNA pairing and strand exchange 38 6.56e-01 4.17e-02 9.47e-01
Separation of Sister Chromatids 161 3.61e-01 4.17e-02 8.43e-01
Keratan sulfate biosynthesis 28 7.03e-01 -4.16e-02 9.60e-01
RHOQ GTPase cycle 57 5.88e-01 -4.15e-02 9.27e-01
Signaling by Erythropoietin 25 7.20e-01 -4.14e-02 9.66e-01
Signaling by ERBB2 TMD/JMD mutants 21 7.43e-01 4.14e-02 9.66e-01
GABA receptor activation 57 5.89e-01 -4.13e-02 9.27e-01
Leishmania infection 156 3.73e-01 -4.13e-02 8.58e-01
Protein ubiquitination 61 5.78e-01 -4.12e-02 9.23e-01
Post-translational modification: synthesis of GPI-anchored proteins 89 5.02e-01 4.11e-02 8.92e-01
Signaling by Nuclear Receptors 237 2.75e-01 4.11e-02 8.20e-01
Glucose metabolism 87 5.07e-01 4.11e-02 8.93e-01
Disorders of Developmental Biology 11 8.15e-01 4.08e-02 9.83e-01
Disorders of Nervous System Development 11 8.15e-01 4.08e-02 9.83e-01
Loss of function of MECP2 in Rett syndrome 11 8.15e-01 4.08e-02 9.83e-01
Pervasive developmental disorders 11 8.15e-01 4.08e-02 9.83e-01
Cell-cell junction organization 56 5.98e-01 -4.08e-02 9.28e-01
Mitotic Metaphase and Anaphase 222 2.96e-01 4.07e-02 8.21e-01
Maturation of nucleoprotein 9683610 11 8.15e-01 4.06e-02 9.83e-01
Gap junction trafficking and regulation 29 7.08e-01 -4.02e-02 9.60e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 15 7.88e-01 -4.01e-02 9.75e-01
Interferon Signaling 191 3.40e-01 -4.00e-02 8.37e-01
Prolonged ERK activation events 14 7.97e-01 3.97e-02 9.79e-01
G alpha (s) signalling events 153 4.00e-01 -3.94e-02 8.64e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 68 5.75e-01 3.93e-02 9.22e-01
Detoxification of Reactive Oxygen Species 35 6.87e-01 3.93e-02 9.56e-01
Integrin signaling 27 7.25e-01 -3.92e-02 9.66e-01
Ribavirin ADME 11 8.22e-01 3.91e-02 9.84e-01
Metalloprotease DUBs 19 7.68e-01 -3.90e-02 9.70e-01
KEAP1-NFE2L2 pathway 103 4.94e-01 3.89e-02 8.92e-01
Cytochrome P450 - arranged by substrate type 64 5.94e-01 3.86e-02 9.28e-01
Extra-nuclear estrogen signaling 73 5.70e-01 3.85e-02 9.18e-01
RND3 GTPase cycle 41 6.72e-01 3.82e-02 9.51e-01
Regulation of RUNX2 expression and activity 71 5.79e-01 3.81e-02 9.23e-01
Glycosphingolipid metabolism 40 6.78e-01 3.80e-02 9.51e-01
CaM pathway 33 7.06e-01 -3.79e-02 9.60e-01
Calmodulin induced events 33 7.06e-01 -3.79e-02 9.60e-01
PPARA activates gene expression 114 4.86e-01 3.77e-02 8.92e-01
DNA Replication Pre-Initiation 97 5.22e-01 3.76e-02 8.96e-01
Assembly and cell surface presentation of NMDA receptors 23 7.55e-01 -3.76e-02 9.67e-01
MHC class II antigen presentation 104 5.08e-01 3.76e-02 8.93e-01
Platelet degranulation 115 4.87e-01 -3.75e-02 8.92e-01
Mitotic Anaphase 221 3.37e-01 3.75e-02 8.37e-01
Metal ion SLC transporters 25 7.47e-01 3.73e-02 9.66e-01
S Phase 157 4.20e-01 3.73e-02 8.76e-01
TRAF6 mediated NF-kB activation 24 7.52e-01 -3.73e-02 9.66e-01
RAF-independent MAPK1/3 activation 22 7.62e-01 3.73e-02 9.68e-01
The canonical retinoid cycle in rods (twilight vision) 23 7.57e-01 3.73e-02 9.67e-01
Physiological factors 14 8.10e-01 -3.72e-02 9.83e-01
Lewis blood group biosynthesis 18 7.85e-01 -3.71e-02 9.75e-01
Inflammasomes 21 7.69e-01 -3.70e-02 9.70e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 8.25e-01 -3.68e-02 9.84e-01
Ca2+ pathway 62 6.16e-01 -3.68e-02 9.28e-01
FGFR2b ligand binding and activation 10 8.41e-01 3.67e-02 9.90e-01
SUMOylation of transcription cofactors 43 6.78e-01 -3.66e-02 9.51e-01
Transcriptional regulation of white adipocyte differentiation 81 5.69e-01 3.66e-02 9.18e-01
Cellular hexose transport 21 7.73e-01 3.64e-02 9.70e-01
RUNX3 regulates NOTCH signaling 13 8.21e-01 3.63e-02 9.84e-01
Processive synthesis on the lagging strand 14 8.16e-01 3.60e-02 9.83e-01
MyD88 dependent cascade initiated on endosome 96 5.45e-01 3.58e-02 9.11e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 96 5.45e-01 3.58e-02 9.11e-01
Host Interactions of HIV factors 122 4.99e-01 3.54e-02 8.92e-01
O-linked glycosylation of mucins 62 6.31e-01 -3.53e-02 9.30e-01
Platelet calcium homeostasis 27 7.52e-01 3.52e-02 9.66e-01
Signaling by Receptor Tyrosine Kinases 493 1.81e-01 3.51e-02 7.64e-01
Infectious disease 830 8.48e-02 3.51e-02 6.52e-01
Processing of SMDT1 15 8.14e-01 3.50e-02 9.83e-01
Telomere Maintenance 62 6.36e-01 3.47e-02 9.33e-01
Pre-NOTCH Processing in Golgi 18 8.00e-01 -3.46e-02 9.80e-01
Biotin transport and metabolism 10 8.50e-01 3.46e-02 9.94e-01
RNA Polymerase III Transcription Initiation 36 7.22e-01 3.43e-02 9.66e-01
Downstream signaling of activated FGFR3 24 7.71e-01 3.43e-02 9.70e-01
Asymmetric localization of PCP proteins 62 6.43e-01 3.41e-02 9.40e-01
Nicotinate metabolism 29 7.53e-01 3.37e-02 9.67e-01
HDR through MMEJ (alt-NHEJ) 11 8.47e-01 3.36e-02 9.92e-01
COPI-independent Golgi-to-ER retrograde traffic 34 7.35e-01 3.35e-02 9.66e-01
Developmental Biology 1027 6.87e-02 3.35e-02 6.23e-01
Triglyceride biosynthesis 13 8.35e-01 -3.34e-02 9.90e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 62 6.51e-01 3.32e-02 9.43e-01
tRNA modification in the nucleus and cytosol 38 7.25e-01 3.30e-02 9.66e-01
Formation of Incision Complex in GG-NER 40 7.19e-01 3.29e-02 9.66e-01
Intracellular signaling by second messengers 313 3.18e-01 3.28e-02 8.29e-01
VEGFA-VEGFR2 Pathway 93 5.85e-01 3.27e-02 9.27e-01
TCF dependent signaling in response to WNT 168 4.65e-01 3.26e-02 8.77e-01
Degradation of AXIN 53 6.82e-01 3.26e-02 9.53e-01
Activation of Matrix Metalloproteinases 31 7.54e-01 3.24e-02 9.67e-01
TCR signaling 112 5.55e-01 -3.22e-02 9.18e-01
Inositol phosphate metabolism 45 7.08e-01 3.22e-02 9.60e-01
Opioid Signalling 88 6.03e-01 -3.21e-02 9.28e-01
Chromatin modifying enzymes 186 4.56e-01 3.17e-02 8.76e-01
Chromatin organization 186 4.56e-01 3.17e-02 8.76e-01
RAS processing 19 8.12e-01 -3.16e-02 9.83e-01
Glucagon signaling in metabolic regulation 33 7.55e-01 -3.14e-02 9.67e-01
Fatty acid metabolism 167 4.84e-01 3.14e-02 8.89e-01
Meiotic synapsis 32 7.60e-01 -3.12e-02 9.68e-01
Class I MHC mediated antigen processing & presentation 361 3.09e-01 -3.11e-02 8.23e-01
Ras activation upon Ca2+ influx through NMDA receptor 19 8.15e-01 3.10e-02 9.83e-01
tRNA Aminoacylation 24 7.93e-01 3.10e-02 9.77e-01
Synthesis of PC 27 7.81e-01 3.10e-02 9.74e-01
Disease 1567 4.03e-02 3.09e-02 4.72e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 14 8.42e-01 -3.08e-02 9.90e-01
Signaling by Hedgehog 133 5.39e-01 3.08e-02 9.11e-01
Transcriptional Regulation by VENTX 41 7.37e-01 3.03e-02 9.66e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 95 6.14e-01 2.99e-02 9.28e-01
Beta-catenin phosphorylation cascade 16 8.36e-01 -2.99e-02 9.90e-01
CD28 dependent PI3K/Akt signaling 22 8.08e-01 2.99e-02 9.83e-01
Response to elevated platelet cytosolic Ca2+ 120 5.74e-01 -2.97e-02 9.21e-01
Assembly of collagen fibrils and other multimeric structures 56 7.01e-01 2.96e-02 9.60e-01
Transcriptional regulation by RUNX2 116 5.82e-01 2.96e-02 9.25e-01
Viral Messenger RNA Synthesis 42 7.40e-01 -2.95e-02 9.66e-01
Downregulation of TGF-beta receptor signaling 26 7.94e-01 2.95e-02 9.77e-01
Cilium Assembly 174 5.02e-01 -2.95e-02 8.92e-01
Ub-specific processing proteases 153 5.33e-01 -2.92e-02 9.03e-01
Translation of Structural Proteins 9683701 29 7.86e-01 2.91e-02 9.75e-01
Mitotic Spindle Checkpoint 106 6.05e-01 2.90e-02 9.28e-01
GLI3 is processed to GLI3R by the proteasome 58 7.02e-01 2.90e-02 9.60e-01
Transcriptional regulation of granulopoiesis 31 7.80e-01 -2.90e-02 9.74e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 104 6.10e-01 2.89e-02 9.28e-01
Orc1 removal from chromatin 69 6.79e-01 2.88e-02 9.51e-01
Nuclear events mediated by NFE2L2 76 6.64e-01 2.88e-02 9.49e-01
PCNA-Dependent Long Patch Base Excision Repair 21 8.19e-01 2.88e-02 9.84e-01
Platelet sensitization by LDL 17 8.38e-01 2.87e-02 9.90e-01
HDMs demethylate histones 18 8.33e-01 2.87e-02 9.89e-01
NRAGE signals death through JNK 53 7.19e-01 2.85e-02 9.66e-01
Membrane Trafficking 585 2.43e-01 2.82e-02 8.07e-01
Nuclear signaling by ERBB4 32 7.83e-01 -2.81e-02 9.75e-01
Regulation of HSF1-mediated heat shock response 78 6.69e-01 2.80e-02 9.50e-01
Peptide ligand-binding receptors 190 5.09e-01 -2.78e-02 8.93e-01
Collagen degradation 39 7.66e-01 2.75e-02 9.70e-01
TNFs bind their physiological receptors 25 8.12e-01 -2.75e-02 9.83e-01
Rab regulation of trafficking 113 6.14e-01 2.74e-02 9.28e-01
Signaling by CSF3 (G-CSF) 28 8.02e-01 -2.74e-02 9.82e-01
Pre-NOTCH Transcription and Translation 45 7.51e-01 2.74e-02 9.66e-01
Branched-chain amino acid catabolism 20 8.32e-01 2.73e-02 9.89e-01
Transcriptional regulation by RUNX1 183 5.24e-01 2.73e-02 8.97e-01
Neurotransmitter release cycle 47 7.46e-01 2.73e-02 9.66e-01
Signaling by FGFR in disease 61 7.13e-01 2.72e-02 9.65e-01
Cellular response to chemical stress 187 5.22e-01 2.71e-02 8.96e-01
Retrograde neurotrophin signalling 14 8.61e-01 2.71e-02 9.96e-01
eNOS activation 11 8.76e-01 2.71e-02 9.96e-01
Fc epsilon receptor (FCERI) signaling 126 6.00e-01 -2.71e-02 9.28e-01
Transcription of E2F targets under negative control by DREAM complex 19 8.39e-01 2.70e-02 9.90e-01
Signal transduction by L1 20 8.35e-01 2.68e-02 9.90e-01
Elevation of cytosolic Ca2+ levels 16 8.53e-01 2.68e-02 9.96e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 10 8.84e-01 2.66e-02 9.96e-01
tRNA processing in the nucleus 55 7.33e-01 -2.66e-02 9.66e-01
Postmitotic nuclear pore complex (NPC) reformation 26 8.15e-01 -2.65e-02 9.83e-01
Toll Like Receptor 3 (TLR3) Cascade 99 6.51e-01 2.63e-02 9.43e-01
Golgi-to-ER retrograde transport 115 6.28e-01 2.62e-02 9.29e-01
Hyaluronan metabolism 17 8.52e-01 2.61e-02 9.96e-01
Glycolysis 68 7.17e-01 2.54e-02 9.66e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 8.90e-01 -2.53e-02 9.96e-01
Cytokine Signaling in Immune system 670 2.63e-01 -2.53e-02 8.19e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 8.57e-01 -2.52e-02 9.96e-01
Defects in cobalamin (B12) metabolism 12 8.81e-01 2.50e-02 9.96e-01
C-type lectin receptors (CLRs) 137 6.15e-01 2.49e-02 9.28e-01
HATs acetylate histones 71 7.18e-01 -2.48e-02 9.66e-01
Interleukin-35 Signalling 12 8.82e-01 -2.47e-02 9.96e-01
PKA activation 18 8.58e-01 -2.44e-02 9.96e-01
SARS-CoV-2-host interactions 183 5.70e-01 -2.43e-02 9.18e-01
Nonhomologous End-Joining (NHEJ) 32 8.12e-01 2.43e-02 9.83e-01
Mitochondrial tRNA aminoacylation 18 8.62e-01 2.38e-02 9.96e-01
Chondroitin sulfate biosynthesis 18 8.62e-01 -2.37e-02 9.96e-01
ECM proteoglycans 55 7.61e-01 2.37e-02 9.68e-01
Interleukin-12 signaling 43 7.88e-01 2.36e-02 9.75e-01
Antigen processing-Cross presentation 100 6.84e-01 2.36e-02 9.54e-01
Signaling by ERBB4 57 7.60e-01 2.34e-02 9.68e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 8.98e-01 -2.34e-02 9.96e-01
Metabolism of proteins 1767 1.02e-01 2.33e-02 6.75e-01
Signaling by WNT 263 5.17e-01 2.32e-02 8.95e-01
Signaling by WNT in cancer 32 8.21e-01 2.31e-02 9.84e-01
COPI-dependent Golgi-to-ER retrograde traffic 81 7.20e-01 2.30e-02 9.66e-01
Antigen processing: Ubiquitination & Proteasome degradation 293 5.03e-01 -2.27e-02 8.92e-01
GPER1 signaling 44 7.95e-01 2.26e-02 9.77e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 8.93e-01 2.25e-02 9.96e-01
alpha-linolenic acid (ALA) metabolism 12 8.93e-01 2.25e-02 9.96e-01
STING mediated induction of host immune responses 13 8.89e-01 2.24e-02 9.96e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 31 8.29e-01 2.24e-02 9.88e-01
ER to Golgi Anterograde Transport 134 6.57e-01 2.22e-02 9.47e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 106 6.93e-01 2.22e-02 9.56e-01
Toll Like Receptor 2 (TLR2) Cascade 106 6.93e-01 2.22e-02 9.56e-01
Toll Like Receptor TLR1:TLR2 Cascade 106 6.93e-01 2.22e-02 9.56e-01
Toll Like Receptor TLR6:TLR2 Cascade 106 6.93e-01 2.22e-02 9.56e-01
Degradation of beta-catenin by the destruction complex 81 7.31e-01 2.21e-02 9.66e-01
Gene Silencing by RNA 80 7.34e-01 -2.20e-02 9.66e-01
Fatty acyl-CoA biosynthesis 36 8.20e-01 2.20e-02 9.84e-01
Degradation of GLI1 by the proteasome 58 7.73e-01 2.19e-02 9.70e-01
Nuclear Events (kinase and transcription factor activation) 60 7.70e-01 -2.18e-02 9.70e-01
The NLRP3 inflammasome 16 8.81e-01 -2.16e-02 9.96e-01
Downstream TCR signaling 92 7.21e-01 2.15e-02 9.66e-01
Centrosome maturation 76 7.47e-01 -2.14e-02 9.66e-01
Recruitment of mitotic centrosome proteins and complexes 76 7.47e-01 -2.14e-02 9.66e-01
G2/M Transition 175 6.27e-01 2.13e-02 9.29e-01
Heme biosynthesis 13 8.95e-01 -2.12e-02 9.96e-01
Constitutive Signaling by Aberrant PI3K in Cancer 77 7.48e-01 -2.12e-02 9.66e-01
Resolution of Sister Chromatid Cohesion 98 7.18e-01 2.11e-02 9.66e-01
NOD1/2 Signaling Pathway 29 8.45e-01 -2.10e-02 9.90e-01
RHOF GTPase cycle 40 8.18e-01 -2.10e-02 9.84e-01
Regulation of beta-cell development 41 8.16e-01 -2.10e-02 9.83e-01
Interleukin-1 family signaling 145 6.63e-01 2.10e-02 9.49e-01
G2/M DNA damage checkpoint 58 7.84e-01 2.08e-02 9.75e-01
Mitotic G2-G2/M phases 177 6.33e-01 2.08e-02 9.31e-01
Cell Cycle 601 3.89e-01 2.05e-02 8.64e-01
Signaling by NOTCH1 70 7.67e-01 2.05e-02 9.70e-01
Signal attenuation 10 9.11e-01 2.04e-02 9.96e-01
RHOA GTPase cycle 140 6.77e-01 -2.04e-02 9.51e-01
Costimulation by the CD28 family 65 7.78e-01 2.02e-02 9.74e-01
tRNA processing 98 7.29e-01 -2.02e-02 9.66e-01
M Phase 335 5.26e-01 2.02e-02 8.99e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 34 8.40e-01 2.00e-02 9.90e-01
Fcgamma receptor (FCGR) dependent phagocytosis 82 7.56e-01 1.99e-02 9.67e-01
Signaling by PDGF 52 8.05e-01 -1.98e-02 9.83e-01
EPHB-mediated forward signaling 34 8.42e-01 -1.98e-02 9.90e-01
Organelle biogenesis and maintenance 243 5.97e-01 -1.97e-02 9.28e-01
SLC transporter disorders 92 7.45e-01 -1.96e-02 9.66e-01
Diseases associated with N-glycosylation of proteins 19 8.83e-01 -1.95e-02 9.96e-01
Diseases associated with visual transduction 11 9.11e-01 -1.94e-02 9.96e-01
Diseases of the neuronal system 11 9.11e-01 -1.94e-02 9.96e-01
Retinoid cycle disease events 11 9.11e-01 -1.94e-02 9.96e-01
RHOC GTPase cycle 69 7.80e-01 -1.94e-02 9.74e-01
PI-3K cascade:FGFR3 17 8.90e-01 1.94e-02 9.96e-01
RUNX2 regulates osteoblast differentiation 22 8.75e-01 1.94e-02 9.96e-01
Activation of ATR in response to replication stress 37 8.39e-01 -1.93e-02 9.90e-01
Circadian Clock 69 7.83e-01 1.92e-02 9.75e-01
Diseases associated with glycosaminoglycan metabolism 38 8.38e-01 1.92e-02 9.90e-01
Cell junction organization 79 7.69e-01 1.91e-02 9.70e-01
Sphingolipid metabolism 81 7.70e-01 1.88e-02 9.70e-01
Platelet homeostasis 85 7.65e-01 -1.88e-02 9.70e-01
Processing and activation of SUMO 10 9.19e-01 -1.85e-02 9.96e-01
Pre-NOTCH Expression and Processing 61 8.02e-01 1.85e-02 9.82e-01
Vesicle-mediated transport 623 4.32e-01 1.84e-02 8.76e-01
Pyrimidine catabolism 12 9.14e-01 -1.81e-02 9.96e-01
Aquaporin-mediated transport 51 8.25e-01 -1.79e-02 9.84e-01
ATF4 activates genes in response to endoplasmic reticulum stress 28 8.70e-01 1.79e-02 9.96e-01
PI3K events in ERBB2 signaling 16 9.01e-01 1.79e-02 9.96e-01
ERBB2 Regulates Cell Motility 15 9.05e-01 1.79e-02 9.96e-01
Growth hormone receptor signaling 24 8.80e-01 1.78e-02 9.96e-01
Signaling by NTRKs 133 7.23e-01 1.78e-02 9.66e-01
Mitochondrial Fatty Acid Beta-Oxidation 35 8.56e-01 1.77e-02 9.96e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 9.17e-01 -1.75e-02 9.96e-01
Negative regulators of DDX58/IFIH1 signaling 34 8.61e-01 -1.74e-02 9.96e-01
IRS-related events triggered by IGF1R 50 8.33e-01 1.73e-02 9.89e-01
DSCAM interactions 11 9.21e-01 1.73e-02 9.96e-01
PI Metabolism 79 7.91e-01 -1.72e-02 9.77e-01
Deadenylation-dependent mRNA decay 56 8.24e-01 -1.72e-02 9.84e-01
MET activates RAS signaling 11 9.22e-01 1.70e-02 9.96e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 8.77e-01 1.69e-02 9.96e-01
Gastrulation 21 8.94e-01 -1.68e-02 9.96e-01
Notch-HLH transcription pathway 24 8.87e-01 -1.68e-02 9.96e-01
G alpha (z) signalling events 48 8.41e-01 -1.68e-02 9.90e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 9.00e-01 1.67e-02 9.96e-01
Mitochondrial calcium ion transport 22 8.92e-01 -1.67e-02 9.96e-01
FRS-mediated FGFR3 signaling 19 9.00e-01 1.67e-02 9.96e-01
Metabolism of amine-derived hormones 17 9.06e-01 -1.65e-02 9.96e-01
Cargo trafficking to the periciliary membrane 49 8.43e-01 -1.64e-02 9.90e-01
Metabolism of lipids 696 4.62e-01 1.63e-02 8.77e-01
FGFR3 ligand binding and activation 12 9.22e-01 1.62e-02 9.96e-01
FGFR3c ligand binding and activation 12 9.22e-01 1.62e-02 9.96e-01
Cytoprotection by HMOX1 58 8.31e-01 1.62e-02 9.89e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 89 7.93e-01 1.61e-02 9.77e-01
Amplification of signal from the kinetochores 89 7.93e-01 1.61e-02 9.77e-01
Purine salvage 12 9.23e-01 1.60e-02 9.96e-01
Interleukin-17 signaling 66 8.22e-01 -1.60e-02 9.84e-01
RND2 GTPase cycle 42 8.58e-01 1.60e-02 9.96e-01
Beta-oxidation of very long chain fatty acids 10 9.31e-01 1.58e-02 9.96e-01
Infection with Mycobacterium tuberculosis 25 8.92e-01 -1.57e-02 9.96e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 67 8.25e-01 1.56e-02 9.84e-01
Toll Like Receptor 9 (TLR9) Cascade 100 7.87e-01 1.56e-02 9.75e-01
Signaling by NTRK1 (TRKA) 114 7.74e-01 1.56e-02 9.71e-01
CD28 dependent Vav1 pathway 11 9.29e-01 -1.55e-02 9.96e-01
Transport to the Golgi and subsequent modification 165 7.31e-01 -1.55e-02 9.66e-01
Metabolism of steroid hormones 33 8.78e-01 1.54e-02 9.96e-01
SARS-CoV-2 Infection 276 6.60e-01 -1.54e-02 9.49e-01
Lagging Strand Synthesis 19 9.08e-01 -1.54e-02 9.96e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 181 7.22e-01 -1.53e-02 9.66e-01
SHC-mediated cascade:FGFR3 17 9.13e-01 1.53e-02 9.96e-01
Cell Cycle, Mitotic 476 5.70e-01 1.52e-02 9.18e-01
SARS-CoV Infections 387 6.09e-01 1.51e-02 9.28e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 25 8.96e-01 -1.51e-02 9.96e-01
Defective Intrinsic Pathway for Apoptosis 25 8.97e-01 1.49e-02 9.96e-01
ATF6 (ATF6-alpha) activates chaperones 11 9.32e-01 -1.49e-02 9.96e-01
DNA strand elongation 31 8.88e-01 -1.47e-02 9.96e-01
Repression of WNT target genes 13 9.28e-01 1.45e-02 9.96e-01
Leading Strand Synthesis 13 9.28e-01 -1.44e-02 9.96e-01
Polymerase switching 13 9.28e-01 -1.44e-02 9.96e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 603 5.46e-01 -1.44e-02 9.11e-01
Metabolism of cofactors 19 9.14e-01 1.43e-02 9.96e-01
Gastrin-CREB signalling pathway via PKC and MAPK 17 9.19e-01 -1.43e-02 9.96e-01
Response of Mtb to phagocytosis 22 9.08e-01 -1.42e-02 9.96e-01
Impaired BRCA2 binding to RAD51 33 8.88e-01 -1.42e-02 9.96e-01
AURKA Activation by TPX2 68 8.40e-01 1.41e-02 9.90e-01
Loss of Nlp from mitotic centrosomes 65 8.44e-01 1.41e-02 9.90e-01
Loss of proteins required for interphase microtubule organization from the centrosome 65 8.44e-01 1.41e-02 9.90e-01
PERK regulates gene expression 32 8.91e-01 -1.40e-02 9.96e-01
Signaling by the B Cell Receptor (BCR) 105 8.06e-01 1.39e-02 9.83e-01
RUNX2 regulates bone development 29 8.99e-01 -1.36e-02 9.96e-01
Intrinsic Pathway for Apoptosis 52 8.65e-01 1.36e-02 9.96e-01
Unwinding of DNA 12 9.35e-01 -1.35e-02 9.96e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 9.41e-01 1.35e-02 9.96e-01
Programmed Cell Death 192 7.48e-01 -1.34e-02 9.66e-01
Signaling by Retinoic Acid 41 8.82e-01 1.34e-02 9.96e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 9.27e-01 1.33e-02 9.96e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 32 8.97e-01 -1.33e-02 9.96e-01
Beta-catenin independent WNT signaling 144 7.84e-01 1.32e-02 9.75e-01
Nucleotide catabolism 35 8.93e-01 1.31e-02 9.96e-01
TP53 Regulates Transcription of Cell Death Genes 42 8.84e-01 1.31e-02 9.96e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 9.22e-01 -1.30e-02 9.96e-01
Cell-Cell communication 112 8.13e-01 -1.30e-02 9.83e-01
CTLA4 inhibitory signaling 21 9.19e-01 1.29e-02 9.96e-01
Nuclear Envelope (NE) Reassembly 73 8.49e-01 1.29e-02 9.94e-01
Negative regulation of MAPK pathway 41 8.87e-01 1.28e-02 9.96e-01
MyD88-independent TLR4 cascade 103 8.24e-01 -1.27e-02 9.84e-01
TRIF(TICAM1)-mediated TLR4 signaling 103 8.24e-01 -1.27e-02 9.84e-01
Collagen chain trimerization 42 8.87e-01 1.27e-02 9.96e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 9.30e-01 -1.26e-02 9.96e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 22 9.18e-01 1.26e-02 9.96e-01
Neurodegenerative Diseases 22 9.18e-01 1.26e-02 9.96e-01
Purine catabolism 17 9.29e-01 1.25e-02 9.96e-01
MET activates RAP1 and RAC1 11 9.44e-01 -1.23e-02 9.96e-01
Transmission across Chemical Synapses 237 7.44e-01 1.23e-02 9.66e-01
Interleukin-4 and Interleukin-13 signaling 104 8.29e-01 1.23e-02 9.88e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 27 9.12e-01 1.23e-02 9.96e-01
Transport of Mature Transcript to Cytoplasm 76 8.56e-01 1.21e-02 9.96e-01
Kinesins 42 8.92e-01 1.21e-02 9.96e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 9.45e-01 1.20e-02 9.96e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 29 9.11e-01 -1.20e-02 9.96e-01
Dissolution of Fibrin Clot 13 9.40e-01 1.20e-02 9.96e-01
IGF1R signaling cascade 51 8.84e-01 1.18e-02 9.96e-01
Signaling by Rho GTPases 589 6.24e-01 -1.18e-02 9.29e-01
Translesion synthesis by REV1 16 9.35e-01 1.17e-02 9.96e-01
Late SARS-CoV-2 Infection Events 67 8.70e-01 -1.16e-02 9.96e-01
Insulin receptor signalling cascade 53 8.85e-01 1.15e-02 9.96e-01
Regulation of gene expression in beta cells 21 9.27e-01 -1.15e-02 9.96e-01
MAPK3 (ERK1) activation 10 9.50e-01 1.15e-02 9.96e-01
G1/S-Specific Transcription 28 9.16e-01 1.15e-02 9.96e-01
trans-Golgi Network Vesicle Budding 67 8.73e-01 1.13e-02 9.96e-01
Activation of NMDA receptors and postsynaptic events 69 8.74e-01 -1.10e-02 9.96e-01
PRC2 methylates histones and DNA 13 9.45e-01 1.10e-02 9.96e-01
Nephrin family interactions 21 9.31e-01 -1.10e-02 9.96e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 49 8.95e-01 -1.09e-02 9.96e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 52 8.92e-01 1.09e-02 9.96e-01
Prefoldin mediated transfer of substrate to CCT/TriC 27 9.22e-01 1.09e-02 9.96e-01
Activation of GABAB receptors 43 9.02e-01 -1.08e-02 9.96e-01
GABA B receptor activation 43 9.02e-01 -1.08e-02 9.96e-01
GRB2 events in ERBB2 signaling 16 9.41e-01 -1.07e-02 9.96e-01
Chromosome Maintenance 86 8.68e-01 1.04e-02 9.96e-01
G alpha (12/13) signalling events 74 8.77e-01 -1.04e-02 9.96e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 15 9.45e-01 -1.02e-02 9.96e-01
EML4 and NUDC in mitotic spindle formation 93 8.65e-01 -1.02e-02 9.96e-01
Mismatch Repair 15 9.45e-01 1.02e-02 9.96e-01
Carboxyterminal post-translational modifications of tubulin 40 9.11e-01 1.02e-02 9.96e-01
Translesion synthesis by POLK 17 9.43e-01 1.01e-02 9.96e-01
Signaling by TGFB family members 118 8.54e-01 9.83e-03 9.96e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 12 9.54e-01 -9.71e-03 9.97e-01
Interferon gamma signaling 89 8.79e-01 -9.35e-03 9.96e-01
Apoptotic execution phase 43 9.16e-01 -9.27e-03 9.96e-01
Removal of the Flap Intermediate 13 9.54e-01 9.14e-03 9.97e-01
Gap junction assembly 18 9.48e-01 8.96e-03 9.96e-01
MAP kinase activation 58 9.06e-01 8.94e-03 9.96e-01
Formation of the beta-catenin:TCF transactivating complex 32 9.31e-01 8.79e-03 9.96e-01
Cargo concentration in the ER 32 9.32e-01 -8.73e-03 9.96e-01
Signaling by Interleukins 434 7.56e-01 -8.68e-03 9.67e-01
Hyaluronan uptake and degradation 12 9.60e-01 8.45e-03 9.97e-01
Hedgehog ‘off’ state 97 8.86e-01 8.40e-03 9.96e-01
Integrin cell surface interactions 66 9.10e-01 -8.03e-03 9.96e-01
Tight junction interactions 28 9.43e-01 7.82e-03 9.96e-01
Platelet Aggregation (Plug Formation) 37 9.35e-01 -7.74e-03 9.96e-01
Rap1 signalling 16 9.57e-01 7.74e-03 9.97e-01
The phototransduction cascade 32 9.41e-01 7.61e-03 9.96e-01
L1CAM interactions 92 9.00e-01 7.59e-03 9.96e-01
PI3K Cascade 43 9.34e-01 7.25e-03 9.96e-01
Apoptosis 164 8.73e-01 -7.21e-03 9.96e-01
Regulation of PTEN stability and activity 66 9.23e-01 6.86e-03 9.96e-01
Neurotransmitter receptors and postsynaptic signal transmission 175 8.76e-01 -6.82e-03 9.96e-01
Interleukin-12 family signaling 53 9.32e-01 -6.79e-03 9.96e-01
Signal Transduction 2410 5.89e-01 -6.68e-03 9.27e-01
ER-Phagosome pathway 87 9.14e-01 -6.67e-03 9.96e-01
WNT5A-dependent internalization of FZD4 15 9.65e-01 -6.59e-03 9.97e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 9.68e-01 6.50e-03 9.97e-01
Regulation of RUNX1 Expression and Activity 25 9.56e-01 -6.43e-03 9.97e-01
Ion homeostasis 50 9.39e-01 6.26e-03 9.96e-01
Golgi Associated Vesicle Biogenesis 51 9.38e-01 -6.25e-03 9.96e-01
HDR through Single Strand Annealing (SSA) 36 9.49e-01 6.14e-03 9.96e-01
Post-translational protein modification 1289 7.16e-01 -6.01e-03 9.66e-01
Diseases of DNA repair 49 9.43e-01 5.89e-03 9.96e-01
HCMV Infection 79 9.29e-01 5.83e-03 9.96e-01
Transcriptional activation of mitochondrial biogenesis 51 9.43e-01 5.76e-03 9.96e-01
Aflatoxin activation and detoxification 19 9.65e-01 5.74e-03 9.97e-01
Anchoring of the basal body to the plasma membrane 92 9.25e-01 -5.69e-03 9.96e-01
Biological oxidations 213 8.86e-01 5.68e-03 9.96e-01
Processing of Intronless Pre-mRNAs 19 9.66e-01 -5.58e-03 9.97e-01
CD28 co-stimulation 32 9.57e-01 -5.48e-03 9.97e-01
Class B/2 (Secretin family receptors) 94 9.28e-01 -5.41e-03 9.96e-01
RHOB GTPase cycle 66 9.40e-01 5.38e-03 9.96e-01
Transcriptional regulation by small RNAs 46 9.50e-01 -5.37e-03 9.96e-01
Mitochondrial biogenesis 69 9.39e-01 5.34e-03 9.96e-01
Inactivation, recovery and regulation of the phototransduction cascade 31 9.59e-01 5.30e-03 9.97e-01
RA biosynthesis pathway 22 9.66e-01 -5.28e-03 9.97e-01
Defects in vitamin and cofactor metabolism 20 9.68e-01 -5.19e-03 9.97e-01
RET signaling 41 9.55e-01 5.12e-03 9.97e-01
Downstream signal transduction 29 9.62e-01 -5.09e-03 9.97e-01
Response to metal ions 14 9.74e-01 -4.94e-03 9.99e-01
RAF/MAP kinase cascade 264 8.92e-01 -4.85e-03 9.96e-01
RIPK1-mediated regulated necrosis 27 9.66e-01 4.81e-03 9.97e-01
Regulation of necroptotic cell death 27 9.66e-01 4.81e-03 9.97e-01
FCGR3A-mediated phagocytosis 57 9.51e-01 4.75e-03 9.96e-01
Leishmania phagocytosis 57 9.51e-01 4.75e-03 9.96e-01
Parasite infection 57 9.51e-01 4.75e-03 9.96e-01
Post NMDA receptor activation events 58 9.50e-01 -4.74e-03 9.96e-01
ISG15 antiviral mechanism 71 9.46e-01 -4.64e-03 9.96e-01
Apoptotic cleavage of cellular proteins 35 9.64e-01 -4.46e-03 9.97e-01
Negative regulation of the PI3K/AKT network 111 9.36e-01 4.39e-03 9.96e-01
RAB geranylgeranylation 57 9.54e-01 -4.39e-03 9.97e-01
MAPK1/MAPK3 signaling 270 9.04e-01 -4.25e-03 9.96e-01
CaMK IV-mediated phosphorylation of CREB 10 9.82e-01 -4.20e-03 9.99e-01
Synthesis of very long-chain fatty acyl-CoAs 23 9.74e-01 3.99e-03 9.99e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 11 9.82e-01 -3.96e-03 9.99e-01
MAPK targets/ Nuclear events mediated by MAP kinases 29 9.71e-01 -3.85e-03 9.99e-01
Interleukin-27 signaling 11 9.82e-01 3.84e-03 9.99e-01
Synthesis of PA 35 9.69e-01 3.82e-03 9.97e-01
TNFR1-induced proapoptotic signaling 13 9.81e-01 -3.77e-03 9.99e-01
RHOD GTPase cycle 48 9.65e-01 -3.71e-03 9.97e-01
Regulation of IFNG signaling 14 9.81e-01 -3.60e-03 9.99e-01
Sensory processing of sound by outer hair cells of the cochlea 49 9.67e-01 3.46e-03 9.97e-01
RHO GTPases Activate WASPs and WAVEs 34 9.73e-01 -3.32e-03 9.99e-01
IRS-mediated signalling 47 9.69e-01 3.31e-03 9.97e-01
Inwardly rectifying K+ channels 35 9.73e-01 3.27e-03 9.99e-01
Cholesterol biosynthesis 24 9.79e-01 3.14e-03 9.99e-01
Metabolism of water-soluble vitamins and cofactors 118 9.53e-01 3.12e-03 9.97e-01
Glucagon-type ligand receptors 33 9.77e-01 2.85e-03 9.99e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 9.82e-01 2.73e-03 9.99e-01
Antiviral mechanism by IFN-stimulated genes 78 9.69e-01 -2.58e-03 9.97e-01
Metallothioneins bind metals 11 9.88e-01 -2.57e-03 9.99e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 101 9.65e-01 2.55e-03 9.97e-01
NOTCH3 Intracellular Domain Regulates Transcription 24 9.83e-01 2.45e-03 9.99e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 9.78e-01 -2.38e-03 9.99e-01
Arachidonic acid metabolism 56 9.76e-01 2.31e-03 9.99e-01
Interleukin-6 family signaling 24 9.85e-01 2.23e-03 9.99e-01
Neurexins and neuroligins 52 9.78e-01 -2.23e-03 9.99e-01
ZBP1(DAI) mediated induction of type I IFNs 20 9.87e-01 -2.13e-03 9.99e-01
Diseases of signal transduction by growth factor receptors and second messengers 410 9.45e-01 -1.98e-03 9.96e-01
SARS-CoV-1 activates/modulates innate immune responses 37 9.84e-01 1.88e-03 9.99e-01
Signaling by ALK 26 9.89e-01 -1.61e-03 9.99e-01
MAPK family signaling cascades 311 9.64e-01 -1.50e-03 9.97e-01
Interaction between L1 and Ankyrins 28 9.89e-01 1.48e-03 9.99e-01
HCMV Late Events 54 9.85e-01 -1.46e-03 9.99e-01
Base Excision Repair 45 9.87e-01 1.44e-03 9.99e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 9.93e-01 -1.37e-03 9.99e-01
Paracetamol ADME 27 9.91e-01 1.30e-03 9.99e-01
Ion transport by P-type ATPases 51 9.87e-01 -1.27e-03 9.99e-01
COPI-mediated anterograde transport 83 9.84e-01 1.24e-03 9.99e-01
Recruitment of NuMA to mitotic centrosomes 75 9.86e-01 1.16e-03 9.99e-01
Mitotic Prometaphase 174 9.84e-01 -9.01e-04 9.99e-01
Blood group systems biosynthesis 22 9.95e-01 7.85e-04 9.99e-01
PI3K/AKT Signaling in Cancer 103 9.90e-01 -7.24e-04 9.99e-01
CTNNB1 S33 mutants aren’t phosphorylated 14 9.97e-01 -6.00e-04 9.99e-01
CTNNB1 S37 mutants aren’t phosphorylated 14 9.97e-01 -6.00e-04 9.99e-01
CTNNB1 S45 mutants aren’t phosphorylated 14 9.97e-01 -6.00e-04 9.99e-01
CTNNB1 T41 mutants aren’t phosphorylated 14 9.97e-01 -6.00e-04 9.99e-01
Signaling by CTNNB1 phospho-site mutants 14 9.97e-01 -6.00e-04 9.99e-01
Signaling by GSK3beta mutants 14 9.97e-01 -6.00e-04 9.99e-01
Role of phospholipids in phagocytosis 23 9.97e-01 5.07e-04 9.99e-01
Oncogene Induced Senescence 35 9.97e-01 -3.36e-04 9.99e-01
mRNA decay by 3’ to 5’ exoribonuclease 16 9.99e-01 -2.33e-04 1.00e+00
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 13 1.00e+00 -7.18e-05 1.00e+00
Sphingolipid de novo biosynthesis 41 1.00e+00 -4.18e-05 1.00e+00


Detailed Gene set reports



Chylomicron remodeling

Chylomicron remodeling
206
set Chylomicron remodeling
setSize 10
pANOVA 0.00305
s.dist 0.541
p.adjustANOVA 0.0813



Top enriched genes

Top 20 genes
GeneID Gene Rank
APOA2 17217
APOA4 17129
LPL 16862
APOC3 15625
APOA5 15294
APOC2 14770
GPIHBP1 8361
APOA1 8252
APOE 5656
APOB 4266

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOA2 17217
APOA4 17129
LPL 16862
APOC3 15625
APOA5 15294
APOC2 14770
GPIHBP1 8361
APOA1 8252
APOE 5656
APOB 4266


TRAF6 mediated IRF7 activation

TRAF6 mediated IRF7 activation
1384
set TRAF6 mediated IRF7 activation
setSize 26
pANOVA 2.37e-05
s.dist -0.479
p.adjustANOVA 0.00127



Top enriched genes

Top 20 genes
GeneID Gene Rank
IFNA6 -7468
IFNA16 -7435
IFNA2 -7322
IFNA21 -7163
IFNB1 -7151
IFNA14 -7144
IFNA1 -7016
TRIM4 -6997
TANK -5818
IFNA5 -5642
SIKE1 -5193
IFNA7 -4213
DDX58 -3097
TBK1 -3086
IFNA8 -2552
EP300 -1077
TRIM25 -689
MAVS 1150
CREBBP 1815
IRF3 6357

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFNA6 -7468
IFNA16 -7435
IFNA2 -7322
IFNA21 -7163
IFNB1 -7151
IFNA14 -7144
IFNA1 -7016
TRIM4 -6997
TANK -5818
IFNA5 -5642
SIKE1 -5193
IFNA7 -4213
DDX58 -3097
TBK1 -3086
IFNA8 -2552
EP300 -1077
TRIM25 -689
MAVS 1150
CREBBP 1815
IRF3 6357
TRAF2 7594
RNF135 7867
IFIH1 7936
IKBKE 10394
TRAF6 12950
IRF7 12961


SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery
1163
set SARS-CoV-1 modulates host translation machinery
setSize 34
pANOVA 8.57e-06
s.dist 0.441
p.adjustANOVA 0.000509



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928.0
RPS10 17181.0
RPS16 16779.0
RPS27A 16523.0
RPS28 16458.0
RPS14 16358.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
HNRNPA1 13954.0
RPS27L 13689.0
RPS23 12899.0
RPS25 12714.5
RPS6 11935.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPS10 17181.0
RPS16 16779.0
RPS27A 16523.0
RPS28 16458.0
RPS14 16358.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
HNRNPA1 13954.0
RPS27L 13689.0
RPS23 12899.0
RPS25 12714.5
RPS6 11935.0
RPS7 11217.0
RPS8 10835.0
RPS2 9470.5
RPS18 8661.0
RPS15 7536.0
RPS5 6716.0
RPS15A 6158.0
RPS3A 4909.0
RPS3 4337.0
RPS13 4131.0
RPS20 2265.0
EEF1A1 748.0
RPS12 -575.0
FAU -3698.0


NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
777
set NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
setSize 12
pANOVA 0.00989
s.dist -0.43
p.adjustANOVA 0.207



Top enriched genes

Top 20 genes
GeneID Gene Rank
TRIM4 -6997
FADD -5407
CHUK -3917
CASP10 -3872
RIPK1 -3687
DDX58 -3097
TRIM25 -689
MAVS 1150
CASP8 3851
IKBKB 5090
RNF135 7867
IFIH1 7936

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRIM4 -6997
FADD -5407
CHUK -3917
CASP10 -3872
RIPK1 -3687
DDX58 -3097
TRIM25 -689
MAVS 1150
CASP8 3851
IKBKB 5090
RNF135 7867
IFIH1 7936


Interaction With Cumulus Cells And The Zona Pellucida

Interaction With Cumulus Cells And The Zona Pellucida
614
set Interaction With Cumulus Cells And The Zona Pellucida
setSize 11
pANOVA 0.017
s.dist -0.416
p.adjustANOVA 0.291



Top enriched genes

Top 20 genes
GeneID Gene Rank
SPAM1 -6586
ADAM2 -4450
ADAM21 -4309
B4GALT1 -3784
ADAM20 -1435
ZP2 315
OVGP1 738
ADAM30 1659
ZP4 1996
ZP1 7373
ZP3 8909

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SPAM1 -6586
ADAM2 -4450
ADAM21 -4309
B4GALT1 -3784
ADAM20 -1435
ZP2 315
OVGP1 738
ADAM30 1659
ZP4 1996
ZP1 7373
ZP3 8909


Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors
399
set Expression and translocation of olfactory receptors
setSize 358
pANOVA 2.87e-37
s.dist -0.391
p.adjustANOVA 4.43e-34



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR8U1 -7415
OR2A12 -7413
OR52D1 -7401
OR52A5 -7378
OR7E24 -7374
OR4Q3 -7353
OR2W3 -7342
OR5P2 -7314
OR10H3 -7308
OR52E4 -7283
OR8D1 -7276
OR6C1 -7261
OR1J2 -7257
OR5K1 -7250
OR2G6 -7245
OR5AC2 -7221
OR52H1 -7217
OR4N4 -7215
OR51G2 -7197
OR5T2 -7167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR8U1 -7415.0
OR2A12 -7413.0
OR52D1 -7401.0
OR52A5 -7378.0
OR7E24 -7374.0
OR4Q3 -7353.0
OR2W3 -7342.0
OR5P2 -7314.0
OR10H3 -7308.0
OR52E4 -7283.0
OR8D1 -7276.0
OR6C1 -7261.0
OR1J2 -7257.0
OR5K1 -7250.0
OR2G6 -7245.0
OR5AC2 -7221.0
OR52H1 -7217.0
OR4N4 -7215.0
OR51G2 -7197.0
OR5T2 -7167.0
OR6M1 -7162.0
OR5F1 -7155.0
OR8H1 -7141.0
OR2G3 -7131.0
OR6K6 -7111.0
OR5K4 -7089.0
OR9G1 -7079.5
OR9G9 -7079.5
OR14A16 -7078.0
OR2B6 -7058.0
OR8B2 -7044.0
OR8K3 -7017.0
OR13C8 -7004.0
OR5AP2 -6995.0
OR6Q1 -6987.0
OR6C75 -6982.0
OR2T10 -6956.0
OR5D18 -6950.0
OR10G8 -6949.0
OR4E2 -6945.0
OR8D2 -6934.0
OR2T33 -6894.0
OR5B12 -6882.0
OR8I2 -6881.0
OR51A7 -6876.0
OR52I2 -6858.0
OR5K3 -6845.0
OR5K2 -6803.0
OR9G4 -6794.0
OR5M9 -6769.0
OR13C4 -6767.0
OR6C3 -6755.0
OR8K1 -6748.0
OR2K2 -6744.0
OR4F15 -6741.0
OR5AN1 -6705.0
OR10W1 -6693.0
OR6C2 -6629.0
OR5AK2 -6622.0
OR2B3 -6599.0
OR6N2 -6597.0
OR6C74 -6594.0
OR4C45 -6582.0
OR12D2 -6563.0
OR51I2 -6552.0
OR4N5 -6525.0
OR10G4 -6502.0
OR8U8 -6474.0
OR1S1 -6468.0
OR10G9 -6425.0
OR56A3 -6423.0
OR4D10 -6390.0
OR7G2 -6385.0
OR11G2 -6311.0
OR2W1 -6253.0
OR10J5 -6237.0
OR5M10 -6207.0
OR4K14 -6193.0
OR51I1 -6187.0
OR5H6 -6135.0
OR5H1 -6116.0
OR3A2 -6102.0
OR13C3 -6079.0
OR6C6 -6059.0
OR1B1 -6013.0
OR2T1 -5989.0
OR8H2 -5919.0
OR5D16 -5918.0
OR10Q1 -5916.0
OR13F1 -5915.0
OR1J1 -5885.0
OR5P3 -5853.0
OR51V1 -5847.0
OR4B1 -5842.0
OR51B6 -5810.0
OR4C46 -5799.0
OR13G1 -5760.0
OR4A16 -5755.0
OR1A1 -5717.0
OR52E6 -5707.0
OR2J2 -5690.0
OR10A4 -5689.0
OR6P1 -5653.0
OR2AG1 -5641.0
OR5AS1 -5633.0
OR6C70 -5600.0
OR8H3 -5585.0
OR5M11 -5579.0
OR10A3 -5426.0
OR13C2 -5349.0
OR10H4 -5297.0
OR1N2 -5266.0
OR2M5 -5243.0
OR5W2 -5238.0
OR10AG1 -5117.0
OR52K2 -5107.0
OR2D3 -5067.0
OR2M4 -5042.0
OR1L3 -5023.0
OR9A2 -4989.0
OR8G1 -4984.0
OR52I1 -4983.0
OR10A6 -4963.0
OR8J1 -4942.0
OR5A1 -4916.0
OR2T6 -4912.0
OR4C13 -4911.0
OR6C4 -4891.0
OR5B3 -4796.0
OR52B6 -4712.0
OR10J1 -4688.0
OR7D4 -4606.0
OR51E2 -4564.0
OR4C6 -4554.0
OR6B3 -4542.0
OR4P4 -4500.0
OR10A7 -4448.0
OR4D5 -4446.0
OR1K1 -4430.0
OR5B2 -4429.0
OR7C1 -4291.0
OR2A14 -4259.0
OR4A47 -4244.0
OR1E1 -4195.0
OR52R1 -4137.0
OR52M1 -4117.0
OR52E8 -4102.0
OR2AK2 -4085.0
OR6F1 -4068.0
OR2T8 -3960.0
OR51B5 -3930.0
OR5M8 -3883.0
OR5M3 -3864.0
OR6T1 -3857.0
OR3A1 -3848.0
OR2S2 -3838.0
OR2L8 -3769.0
OR10H1 -3732.0
OR5T3 -3725.0
OR11A1 -3695.0
OR4C12 -3693.0
OR2H1 -3665.0
OR6C76 -3663.0
OR5I1 -3654.0
OR8J3 -3642.0
OR10G3 -3633.0
OR6B1 -3604.0
OR56A1 -3541.0
OR14J1 -3539.0
OR10K2 -3442.0
OR7A10 -3399.0
OR6A2 -3204.0
OR2L5 -3158.0
OR10AD1 -3091.0
OR11H4 -3064.0
OR51B4 -3056.0
OR51B2 -3038.0
OR2L13 -2905.0
OR4M1 -2777.0
OR7G1 -2716.0
OR4N2 -2660.0
OR2B2 -2565.0
OR5R1 -2549.0
OR1A2 -2366.0
OR1Q1 -2210.0
OR4K13 -2196.0
OR1C1 -2191.0
OR2J3 -2176.0
OR7D2 -2098.0
OR52N1 -1926.0
OR10G2 -1792.0
OR5L2 -1734.0
OR51D1 -1660.0
OR10T2 -1561.0
OR2Y1 -1477.0
OR4X2 -1471.0
OR8B12 -1453.0
OR7A5 -1450.0
OR5M1 -1399.0
OR51L1 -1394.0
OR51T1 -1377.0
OR2T3 -1289.0
OR4K17 -1260.0
OR5H15 -1237.0
OR5AU1 -1176.0
OR5H2 -1170.0
OR2F1 -1152.0
OR10G7 -1122.0
OR5C1 -1040.0
OR1J4 -1033.0
OR4D9 -963.0
OR5V1 -892.0
OR5T1 -865.0
OR4F6 -377.0
OR12D3 -246.0
OR1N1 -203.0
OR13C9 -182.0
OR14C36 -139.0
OR1D2 5.0
OR2V2 107.0
REEP1 338.0
OR52E2 485.0
OR14I1 553.0
OR10P1 630.0
OR10S1 728.0
OR2T34 756.0
OR6X1 773.0
OR4K1 993.0
OR52A1 1216.0
OR52N5 1226.0
OR7C2 1251.0
OR5A2 1277.0
OR51A2 1341.0
OR4K15 1465.0
OR1I1 1479.0
OR9Q1 1502.0
OR9Q2 1602.0
OR8S1 1629.0
OR5D14 1654.0
OR6C65 1715.0
OR6V1 2074.0
OR4X1 2329.0
OR56A4 2333.0
OR2A2 2444.0
OR11H6 2448.0
OR2T4 2667.0
OR1M1 2782.0
OR51M1 2883.0
OR52N2 2924.0
OR2T11 2943.0
OR52J3 2998.0
OR4A15 3223.0
OR10C1 3369.0
OR6S1 3452.0
OR2M3 3493.0
OR4L1 3533.0
OR4D1 3576.0
OR2T27 4184.0
OR4D2 4330.0
OR4K2 4470.0
OR8A1 4564.0
OR4D11 4681.0
OR2A25 4747.0
EBF1 4836.0
OR5B17 4937.0
OR9K2 5359.0
OR1E2 5639.0
OR52K1 5680.0
OR1L6 5790.0
OR9I1 5810.0
OR2M7 5875.0
OR4C15 6193.0
OR51S1 6242.0
OR4M2 6605.0
OR4D6 6636.0
OR6B2 6778.0
OR7A17 6824.0
OR13J1 6913.0
OR8G5 7155.0
OR1L8 7189.0
OR11L1 7390.0
OR2AE1 7447.0
OR4K5 7610.0
OR1L4 7886.0
OR1L1 8541.0
OR2W5 8612.0
OR6Y1 8617.0
OR6K3 8641.0
OR4C16 8753.0
OR56B1 8832.0
OR1F1 8880.0
OR8K5 8895.0
RTP1 9085.0
OR51G1 9321.0
OR10X1 9519.0
OR5D13 9650.0
OR51E1 9770.0
OR10A5 9803.0
OR2B11 9874.0
OR10A2 9973.0
OR52L1 10107.0
OR2C1 10203.0
OR2F2 10446.0
OR2Z1 10616.0
OR5J2 10713.0
OR2C3 10797.0
OR2AT4 10809.0
OR2H2 10855.0
OR5B21 11248.0
OR51F2 11292.0
OR11H2 11369.0
OR10Z1 11503.0
LHX2 11824.0
OR51A4 11831.0
OR10K1 12149.0
OR13A1 12233.0
OR2D2 12286.0
OR4S2 12406.0
OR3A3 12412.0
LDB1 12926.0
OR4C3 13177.0
OR2G2 13257.0
OR2L3 13426.0
OR4S1 13694.0
OR8D4 13815.0
OR9A4 14233.0
OR4A5 14257.0
OR10H5 14526.0
OR6K2 14556.0
OR1S2 14969.0
OR5L1 15152.0
OR10V1 15399.0
OR1G1 15541.0
OR5AR1 15552.0
OR51Q1 15584.0
OR10J3 15681.0
OR10R2 16010.0
OR10H2 16153.0
OR6N1 16233.0
OR56A5 16326.0
OR2V1 16484.0
OR2M2 16504.0
OR8B4 16713.0
OR2AP1 16838.0
OR6C68 16889.0
OR52B2 17034.0
OR2AG2 17037.0
OR51F1 17180.0
OR52W1 17351.0
OR2L2 17379.0
OR8B8 17557.0
RTP2 17644.0
OR56B4 17651.0
OR2A5 18021.0
OR8G2 18054.0
OR13D1 18175.0
OR4C11 18193.0
OR7G3 18240.0


Class C/3 (Metabotropic glutamate/pheromone receptors)

Class C/3 (Metabotropic glutamate/pheromone receptors)
212
set Class C/3 (Metabotropic glutamate/pheromone receptors)
setSize 39
pANOVA 2.37e-05
s.dist -0.391
p.adjustANOVA 0.00127



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAS2R46 -7452
TAS2R10 -7310
TAS2R14 -6919
TAS2R30 -6829
TAS2R50 -6669
TAS2R4 -6595
TAS2R3 -6571
TAS2R43 -6544
TAS2R39 -6461
TAS2R13 -6294
TAS2R8 -6293
TAS2R60 -6164
TAS2R7 -5710
TAS2R31 -5577
TAS2R16 -4849
TAS2R5 -4738
TAS2R42 -4731
GRM5 -3756
TAS1R2 -1546
CASR -216

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAS2R46 -7452
TAS2R10 -7310
TAS2R14 -6919
TAS2R30 -6829
TAS2R50 -6669
TAS2R4 -6595
TAS2R3 -6571
TAS2R43 -6544
TAS2R39 -6461
TAS2R13 -6294
TAS2R8 -6293
TAS2R60 -6164
TAS2R7 -5710
TAS2R31 -5577
TAS2R16 -4849
TAS2R5 -4738
TAS2R42 -4731
GRM5 -3756
TAS1R2 -1546
CASR -216
GRM2 1073
TAS2R20 1309
GRM1 1770
TAS2R19 2118
TAS2R1 2865
GRM7 3154
TAS2R9 3397
TAS1R3 4261
GRM6 4303
GABBR2 5340
GRM8 5532
GPRC6A 7900
TAS2R41 9704
GRM4 9830
TAS2R38 10441
GABBR1 11256
TAS2R40 11572
GRM3 12751
TAS1R1 16655


Caspase activation via Death Receptors in the presence of ligand

Caspase activation via Death Receptors in the presence of ligand
172
set Caspase activation via Death Receptors in the presence of ligand
setSize 16
pANOVA 0.00813
s.dist -0.382
p.adjustANOVA 0.175



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD14 -6790
LY96 -6284
FADD -5407
FASLG -5334
RIPK1 -3687
TICAM2 -2212
CFLAR -1598
TLR4 -1541
TICAM1 541
TNFSF10 2616
TNFRSF10B 2934
FAS 3536
CASP8 3851
TNFRSF10A 4713
TRAF2 7594
TRADD 14572

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD14 -6790
LY96 -6284
FADD -5407
FASLG -5334
RIPK1 -3687
TICAM2 -2212
CFLAR -1598
TLR4 -1541
TICAM1 541
TNFSF10 2616
TNFRSF10B 2934
FAS 3536
CASP8 3851
TNFRSF10A 4713
TRAF2 7594
TRADD 14572


Olfactory Signaling Pathway

Olfactory Signaling Pathway
853
set Olfactory Signaling Pathway
setSize 365
pANOVA 4.02e-36
s.dist -0.381
p.adjustANOVA 3.11e-33



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR8U1 -7415
OR2A12 -7413
OR52D1 -7401
OR52A5 -7378
OR7E24 -7374
OR4Q3 -7353
OR2W3 -7342
OR5P2 -7314
OR10H3 -7308
OR52E4 -7283
OR8D1 -7276
OR6C1 -7261
OR1J2 -7257
OR5K1 -7250
OR2G6 -7245
OR5AC2 -7221
OR52H1 -7217
OR4N4 -7215
OR51G2 -7197
OR5T2 -7167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR8U1 -7415.0
OR2A12 -7413.0
OR52D1 -7401.0
OR52A5 -7378.0
OR7E24 -7374.0
OR4Q3 -7353.0
OR2W3 -7342.0
OR5P2 -7314.0
OR10H3 -7308.0
OR52E4 -7283.0
OR8D1 -7276.0
OR6C1 -7261.0
OR1J2 -7257.0
OR5K1 -7250.0
OR2G6 -7245.0
OR5AC2 -7221.0
OR52H1 -7217.0
OR4N4 -7215.0
OR51G2 -7197.0
OR5T2 -7167.0
OR6M1 -7162.0
OR5F1 -7155.0
OR8H1 -7141.0
OR2G3 -7131.0
OR6K6 -7111.0
OR5K4 -7089.0
OR9G1 -7079.5
OR9G9 -7079.5
OR14A16 -7078.0
OR2B6 -7058.0
OR8B2 -7044.0
OR8K3 -7017.0
OR13C8 -7004.0
OR5AP2 -6995.0
OR6Q1 -6987.0
OR6C75 -6982.0
OR2T10 -6956.0
OR5D18 -6950.0
OR10G8 -6949.0
OR4E2 -6945.0
OR8D2 -6934.0
OR2T33 -6894.0
OR5B12 -6882.0
OR8I2 -6881.0
OR51A7 -6876.0
OR52I2 -6858.0
OR5K3 -6845.0
OR5K2 -6803.0
OR9G4 -6794.0
OR5M9 -6769.0
OR13C4 -6767.0
OR6C3 -6755.0
OR8K1 -6748.0
OR2K2 -6744.0
OR4F15 -6741.0
OR5AN1 -6705.0
OR10W1 -6693.0
OR6C2 -6629.0
OR5AK2 -6622.0
OR2B3 -6599.0
OR6N2 -6597.0
OR6C74 -6594.0
OR4C45 -6582.0
OR12D2 -6563.0
OR51I2 -6552.0
OR4N5 -6525.0
OR10G4 -6502.0
OR8U8 -6474.0
OR1S1 -6468.0
OR10G9 -6425.0
OR56A3 -6423.0
OR4D10 -6390.0
OR7G2 -6385.0
OR11G2 -6311.0
OR2W1 -6253.0
OR10J5 -6237.0
OR5M10 -6207.0
OR4K14 -6193.0
OR51I1 -6187.0
OR5H6 -6135.0
OR5H1 -6116.0
OR3A2 -6102.0
OR13C3 -6079.0
OR6C6 -6059.0
OR1B1 -6013.0
OR2T1 -5989.0
OR8H2 -5919.0
OR5D16 -5918.0
OR10Q1 -5916.0
OR13F1 -5915.0
OR1J1 -5885.0
OR5P3 -5853.0
OR51V1 -5847.0
OR4B1 -5842.0
OR51B6 -5810.0
OR4C46 -5799.0
OR13G1 -5760.0
OR4A16 -5755.0
OR1A1 -5717.0
OR52E6 -5707.0
OR2J2 -5690.0
OR10A4 -5689.0
OR6P1 -5653.0
OR2AG1 -5641.0
OR5AS1 -5633.0
OR6C70 -5600.0
OR8H3 -5585.0
OR5M11 -5579.0
OR10A3 -5426.0
OR13C2 -5349.0
OR10H4 -5297.0
OR1N2 -5266.0
OR2M5 -5243.0
OR5W2 -5238.0
OR10AG1 -5117.0
OR52K2 -5107.0
OR2D3 -5067.0
OR2M4 -5042.0
OR1L3 -5023.0
OR9A2 -4989.0
OR8G1 -4984.0
OR52I1 -4983.0
OR10A6 -4963.0
OR8J1 -4942.0
OR5A1 -4916.0
OR2T6 -4912.0
OR4C13 -4911.0
OR6C4 -4891.0
OR5B3 -4796.0
OR52B6 -4712.0
OR10J1 -4688.0
OR7D4 -4606.0
OR51E2 -4564.0
OR4C6 -4554.0
OR6B3 -4542.0
OR4P4 -4500.0
OR10A7 -4448.0
OR4D5 -4446.0
OR1K1 -4430.0
OR5B2 -4429.0
OR7C1 -4291.0
OR2A14 -4259.0
OR4A47 -4244.0
OR1E1 -4195.0
OR52R1 -4137.0
OR52M1 -4117.0
OR52E8 -4102.0
OR2AK2 -4085.0
OR6F1 -4068.0
OR2T8 -3960.0
OR51B5 -3930.0
OR5M8 -3883.0
OR5M3 -3864.0
OR6T1 -3857.0
OR3A1 -3848.0
OR2S2 -3838.0
OR2L8 -3769.0
OR10H1 -3732.0
OR5T3 -3725.0
OR11A1 -3695.0
OR4C12 -3693.0
OR2H1 -3665.0
OR6C76 -3663.0
OR5I1 -3654.0
OR8J3 -3642.0
OR10G3 -3633.0
OR6B1 -3604.0
GNG13 -3542.0
OR56A1 -3541.0
OR14J1 -3539.0
OR10K2 -3442.0
OR7A10 -3399.0
OR6A2 -3204.0
OR2L5 -3158.0
OR10AD1 -3091.0
OR11H4 -3064.0
OR51B4 -3056.0
OR51B2 -3038.0
OR2L13 -2905.0
OR4M1 -2777.0
OR7G1 -2716.0
OR4N2 -2660.0
OR2B2 -2565.0
OR5R1 -2549.0
OR1A2 -2366.0
OR1Q1 -2210.0
OR4K13 -2196.0
OR1C1 -2191.0
OR2J3 -2176.0
OR7D2 -2098.0
OR52N1 -1926.0
OR10G2 -1792.0
OR5L2 -1734.0
OR51D1 -1660.0
OR10T2 -1561.0
OR2Y1 -1477.0
OR4X2 -1471.0
OR8B12 -1453.0
OR7A5 -1450.0
OR5M1 -1399.0
OR51L1 -1394.0
OR51T1 -1377.0
OR2T3 -1289.0
OR4K17 -1260.0
OR5H15 -1237.0
OR5AU1 -1176.0
OR5H2 -1170.0
OR2F1 -1152.0
OR10G7 -1122.0
OR5C1 -1040.0
OR1J4 -1033.0
OR4D9 -963.0
OR5V1 -892.0
OR5T1 -865.0
OR4F6 -377.0
OR12D3 -246.0
OR1N1 -203.0
OR13C9 -182.0
OR14C36 -139.0
OR1D2 5.0
OR2V2 107.0
REEP1 338.0
OR52E2 485.0
OR14I1 553.0
OR10P1 630.0
OR10S1 728.0
OR2T34 756.0
OR6X1 773.0
OR4K1 993.0
OR52A1 1216.0
OR52N5 1226.0
OR7C2 1251.0
OR5A2 1277.0
OR51A2 1341.0
OR4K15 1465.0
OR1I1 1479.0
OR9Q1 1502.0
OR9Q2 1602.0
OR8S1 1629.0
OR5D14 1654.0
OR6C65 1715.0
OR6V1 2074.0
OR4X1 2329.0
OR56A4 2333.0
OR2A2 2444.0
OR11H6 2448.0
OR2T4 2667.0
OR1M1 2782.0
OR51M1 2883.0
OR52N2 2924.0
OR2T11 2943.0
OR52J3 2998.0
ANO2 3156.0
OR4A15 3223.0
OR10C1 3369.0
OR6S1 3452.0
OR2M3 3493.0
OR4L1 3533.0
OR4D1 3576.0
OR2T27 4184.0
OR4D2 4330.0
OR4K2 4470.0
OR8A1 4564.0
OR4D11 4681.0
OR2A25 4747.0
GNB1 4758.0
EBF1 4836.0
OR5B17 4937.0
GNAL 5309.0
OR9K2 5359.0
OR1E2 5639.0
OR52K1 5680.0
OR1L6 5790.0
OR9I1 5810.0
OR2M7 5875.0
OR4C15 6193.0
OR51S1 6242.0
OR4M2 6605.0
OR4D6 6636.0
OR6B2 6778.0
OR7A17 6824.0
OR13J1 6913.0
OR8G5 7155.0
OR1L8 7189.0
OR11L1 7390.0
OR2AE1 7447.0
OR4K5 7610.0
OR1L4 7886.0
OR1L1 8541.0
OR2W5 8612.0
OR6Y1 8617.0
OR6K3 8641.0
OR4C16 8753.0
OR56B1 8832.0
OR1F1 8880.0
OR8K5 8895.0
RTP1 9085.0
OR51G1 9321.0
OR10X1 9519.0
OR5D13 9650.0
OR51E1 9770.0
OR10A5 9803.0
OR2B11 9874.0
OR10A2 9973.0
OR52L1 10107.0
OR2C1 10203.0
OR2F2 10446.0
OR2Z1 10616.0
OR5J2 10713.0
OR2C3 10797.0
OR2AT4 10809.0
OR2H2 10855.0
OR5B21 11248.0
OR51F2 11292.0
OR11H2 11369.0
OR10Z1 11503.0
LHX2 11824.0
OR51A4 11831.0
OR10K1 12149.0
OR13A1 12233.0
OR2D2 12286.0
ADCY3 12397.0
OR4S2 12406.0
OR3A3 12412.0
LDB1 12926.0
CNGA4 13050.0
OR4C3 13177.0
OR2G2 13257.0
OR2L3 13426.0
OR4S1 13694.0
OR8D4 13815.0
OR9A4 14233.0
OR4A5 14257.0
OR10H5 14526.0
OR6K2 14556.0
CNGB1 14611.0
OR1S2 14969.0
OR5L1 15152.0
OR10V1 15399.0
OR1G1 15541.0
OR5AR1 15552.0
OR51Q1 15584.0
OR10J3 15681.0
OR10R2 16010.0
OR10H2 16153.0
OR6N1 16233.0
OR56A5 16326.0
OR2V1 16484.0
OR2M2 16504.0
OR8B4 16713.0
OR2AP1 16838.0
OR6C68 16889.0
OR52B2 17034.0
OR2AG2 17037.0
OR51F1 17180.0
OR52W1 17351.0
OR2L2 17379.0
OR8B8 17557.0
RTP2 17644.0
OR56B4 17651.0
OR2A5 18021.0
OR8G2 18054.0
OR13D1 18175.0
OR4C11 18193.0
OR7G3 18240.0


Glucuronidation

Glucuronidation
516
set Glucuronidation
setSize 25
pANOVA 0.00116
s.dist -0.375
p.adjustANOVA 0.0417



Top enriched genes

Top 20 genes
GeneID Gene Rank
UGT2A3 -7350.0
UGT2A2 -7243.0
UGT2B10 -7237.0
UGT2A1 -6534.0
UGT2B17 -6267.0
UGT2B15 -6266.0
UGT2B28 -6112.0
UGT2B4 -5459.0
SLC35D1 -4152.0
UGT2B11 -3483.0
UGT3A2 -2945.0
UGT3A1 -688.0
UGT1A1 -650.0
UGP2 101.0
UGT1A4 1402.5
UGT1A5 1402.5
UGT1A3 3217.0
UGT2B7 6422.0
UGDH 7285.0
UGT1A10 9182.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UGT2A3 -7350.0
UGT2A2 -7243.0
UGT2B10 -7237.0
UGT2A1 -6534.0
UGT2B17 -6267.0
UGT2B15 -6266.0
UGT2B28 -6112.0
UGT2B4 -5459.0
SLC35D1 -4152.0
UGT2B11 -3483.0
UGT3A2 -2945.0
UGT3A1 -688.0
UGT1A1 -650.0
UGP2 101.0
UGT1A4 1402.5
UGT1A5 1402.5
UGT1A3 3217.0
UGT2B7 6422.0
UGDH 7285.0
UGT1A10 9182.0
UGT1A9 9455.0
UGT1A7 9811.5
UGT1A8 9811.5
UGT1A6 10117.0
ABHD10 10144.0


Diseases associated with glycosylation precursor biosynthesis

Diseases associated with glycosylation precursor biosynthesis
324
set Diseases associated with glycosylation precursor biosynthesis
setSize 15
pANOVA 0.0119
s.dist 0.375
p.adjustANOVA 0.23



Top enriched genes

Top 20 genes
GeneID Gene Rank
DPM3 17740.0
GFPT1 16865.0
DPM1 16184.5
DOLK 15670.0
PGM1 15109.0
GALE 13102.0
DPM2 13096.0
GALK1 13024.0
SRD5A3 10709.0
NUS1 10233.0
DHDDS 9745.0
PMM2 2695.0
GALT 2605.0
MPI 73.0
GNE -3747.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DPM3 17740.0
GFPT1 16865.0
DPM1 16184.5
DOLK 15670.0
PGM1 15109.0
GALE 13102.0
DPM2 13096.0
GALK1 13024.0
SRD5A3 10709.0
NUS1 10233.0
DHDDS 9745.0
PMM2 2695.0
GALT 2605.0
MPI 73.0
GNE -3747.0


Chylomicron assembly

Chylomicron assembly
205
set Chylomicron assembly
setSize 10
pANOVA 0.0423
s.dist 0.371
p.adjustANOVA 0.491



Top enriched genes

Top 20 genes
GeneID Gene Rank
APOA2 17217.0
APOA4 17129.0
APOC3 15625.0
APOC2 14770.0
MTTP 12552.5
APOA1 8252.0
SAR1B 7161.0
APOE 5656.0
APOB 4266.0
P4HB -1080.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOA2 17217.0
APOA4 17129.0
APOC3 15625.0
APOC2 14770.0
MTTP 12552.5
APOA1 8252.0
SAR1B 7161.0
APOE 5656.0
APOB 4266.0
P4HB -1080.0


Phase 4 - resting membrane potential

Phase 4 - resting membrane potential
913
set Phase 4 - resting membrane potential
setSize 19
pANOVA 0.00633
s.dist 0.362
p.adjustANOVA 0.146



Top enriched genes

Top 20 genes
GeneID Gene Rank
KCNK18 17657
KCNK16 17623
KCNJ4 16023
KCNJ14 15907
KCNJ12 15499
KCNK6 14054
KCNK5 12973
KCNK15 11712
KCNJ2 11455
KCNK7 10824
KCNK17 9354
KCNK4 9125
KCNK3 9118
KCNK10 8755
KCNK12 5494
KCNK9 3675
KCNK13 1281
KCNK1 261
KCNK2 -103

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KCNK18 17657
KCNK16 17623
KCNJ4 16023
KCNJ14 15907
KCNJ12 15499
KCNK6 14054
KCNK5 12973
KCNK15 11712
KCNJ2 11455
KCNK7 10824
KCNK17 9354
KCNK4 9125
KCNK3 9118
KCNK10 8755
KCNK12 5494
KCNK9 3675
KCNK13 1281
KCNK1 261
KCNK2 -103


mRNA Editing

mRNA Editing
1521
set mRNA Editing
setSize 10
pANOVA 0.0527
s.dist -0.354
p.adjustANOVA 0.569



Top enriched genes

Top 20 genes
GeneID Gene Rank
A1CF -6315
APOBEC4 -3549
APOBEC3B -2492
APOBEC3C -1811
APOBEC3H -1121
APOBEC3A -1102
APOBEC1 982
ADARB1 3072
APOBEC2 5695
ADAR 14963

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
A1CF -6315
APOBEC4 -3549
APOBEC3B -2492
APOBEC3C -1811
APOBEC3H -1121
APOBEC3A -1102
APOBEC1 982
ADARB1 3072
APOBEC2 5695
ADAR 14963


NF-kB is activated and signals survival

NF-kB is activated and signals survival
778
set NF-kB is activated and signals survival
setSize 12
pANOVA 0.0344
s.dist 0.353
p.adjustANOVA 0.438



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 16523
NFKBIA 15601
UBC 13572
TRAF6 12950
UBB 12753
RELA 12174
NGF 9591
NGFR 8785
SQSTM1 6440
IKBKB 5090
UBA52 4986
NFKB1 571

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 16523
NFKBIA 15601
UBC 13572
TRAF6 12950
UBB 12753
RELA 12174
NGF 9591
NGFR 8785
SQSTM1 6440
IKBKB 5090
UBA52 4986
NFKB1 571


Signaling by cytosolic FGFR1 fusion mutants

Signaling by cytosolic FGFR1 fusion mutants
1310
set Signaling by cytosolic FGFR1 fusion mutants
setSize 17
pANOVA 0.0124
s.dist -0.35
p.adjustANOVA 0.236



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZMYM2 -5033.0
GAB2 -3577.0
STAT5B -3526.0
FGFR1OP2 -3190.5
STAT1 -2931.0
TRIM24 -2631.0
STAT5A -2524.0
CNTRL -1927.0
CUX1 -1153.0
STAT3 287.0
LRRFIP1 2119.0
BCR 4764.0
PIK3CA 5312.0
GRB2 5702.0
PIK3R1 6497.0
CPSF6 7431.0
MYO18A 9301.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZMYM2 -5033.0
GAB2 -3577.0
STAT5B -3526.0
FGFR1OP2 -3190.5
STAT1 -2931.0
TRIM24 -2631.0
STAT5A -2524.0
CNTRL -1927.0
CUX1 -1153.0
STAT3 287.0
LRRFIP1 2119.0
BCR 4764.0
PIK3CA 5312.0
GRB2 5702.0
PIK3R1 6497.0
CPSF6 7431.0
MYO18A 9301.0


Synthesis of PIPs at the late endosome membrane

Synthesis of PIPs at the late endosome membrane
1342
set Synthesis of PIPs at the late endosome membrane
setSize 10
pANOVA 0.0656
s.dist -0.336
p.adjustANOVA 0.611



Top enriched genes

Top 20 genes
GeneID Gene Rank
PIK3C2A -6704
PIK3C3 -4860
MTMR9 -4044
PIKFYVE -1808
MTMR2 -1503
PIK3R4 -343
MTMR7 537
FIG4 4347
VAC14 12173
MTMR4 12796

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIK3C2A -6704
PIK3C3 -4860
MTMR9 -4044
PIKFYVE -1808
MTMR2 -1503
PIK3R4 -343
MTMR7 537
FIG4 4347
VAC14 12173
MTMR4 12796


Viral mRNA Translation

Viral mRNA Translation
1496
set Viral mRNA Translation
setSize 84
pANOVA 1.4e-07
s.dist 0.332
p.adjustANOVA 2.7e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928
RPL10L 17345
RPL34 17330
RPL27 17307
RPL23 17292
RPL18A 17183
RPS10 17181
RPL35A 17098
RPS16 16779
RPL32 16664
RPS27A 16523
RPL24 16506
RPS28 16458
RPS14 16358
RPL17 16189
RPS29 16138
RPS9 16050
RPSA 16030
RPS19 15679
RPL28 15605

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPL10L 17345.0
RPL34 17330.0
RPL27 17307.0
RPL23 17292.0
RPL18A 17183.0
RPS10 17181.0
RPL35A 17098.0
RPS16 16779.0
RPL32 16664.0
RPS27A 16523.0
RPL24 16506.0
RPS28 16458.0
RPS14 16358.0
RPL17 16189.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
RPL28 15605.0
RPL26L1 15561.5
RPL38 14997.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
RPL7 13881.0
RPL13A 13855.5
RPS27L 13689.0
GRSF1 13560.0
RPS23 12899.0
RPS25 12714.5
RPL19 12327.0
RPS6 11935.0
RPL41 11601.0
RPS7 11217.0
RPL7A 11203.5
RPS8 10835.0
RPL3L 10775.0
RPL9 10376.0
RPLP2 10294.0
RPL36AL 9850.0
RPLP1 9499.0
RPS2 9470.5
RPL13 9381.5
RPL30 9189.0
RPL29 9040.0
RPS18 8661.0
DNAJC3 8441.0
RPL4 8015.0
RPL14 7987.0
RPL26 7877.0
RPS15 7536.0
RPL23A 7183.0
RPL12 7117.0
RPS5 6716.0
RPL21 6561.0
RPL8 6517.0
RPL37 6491.0
RPL37A 6372.0
RPS15A 6158.0
RPL22 5299.0
UBA52 4986.0
RPS3A 4909.0
RPL22L1 4649.0
RPL3 4399.5
RPS3 4337.0
RPS13 4131.0
RPL5 2965.0
RPL31 2893.0
RPS20 2265.0
RPL18 2245.0
RPL11 1692.0
RPL36 1435.0
RPL39L 484.0
RPL10A 307.0
RPLP0 -192.0
RPS12 -575.0
RPL35 -1039.0
RPL6 -1615.0
RPL15 -2406.5
RPL27A -3404.0
FAU -3698.0


Cytosolic iron-sulfur cluster assembly

Cytosolic iron-sulfur cluster assembly
252
set Cytosolic iron-sulfur cluster assembly
setSize 10
pANOVA 0.0701
s.dist 0.331
p.adjustANOVA 0.623



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDOR1 14654.0
POLD1 14360.0
CIAPIN1 12843.0
RTEL1 12506.0
NUBP1 10970.0
MMS19 9469.0
BRIP1 6658.0
NUBP2 6265.0
CIAO1 5409.5
ERCC2 3252.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDOR1 14654.0
POLD1 14360.0
CIAPIN1 12843.0
RTEL1 12506.0
NUBP1 10970.0
MMS19 9469.0
BRIP1 6658.0
NUBP2 6265.0
CIAO1 5409.5
ERCC2 3252.0


Regulation of NF-kappa B signaling

Regulation of NF-kappa B signaling
1091
set Regulation of NF-kappa B signaling
setSize 17
pANOVA 0.0183
s.dist 0.33
p.adjustANOVA 0.305



Top enriched genes

Top 20 genes
GeneID Gene Rank
LRRC14 16756
RPS27A 16523
USP18 15611
UBC 13572
TRAF6 12950
UBB 12753
NLRC5 12511
IKBIP 12175
USP14 11471
NLRX1 11084
TP53 10118
TRAF2 7594
IKBKB 5090
UBA52 4986
CASP8 3851
N4BP1 642
CHUK -3917

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LRRC14 16756
RPS27A 16523
USP18 15611
UBC 13572
TRAF6 12950
UBB 12753
NLRC5 12511
IKBIP 12175
USP14 11471
NLRX1 11084
TP53 10118
TRAF2 7594
IKBKB 5090
UBA52 4986
CASP8 3851
N4BP1 642
CHUK -3917


Eukaryotic Translation Termination

Eukaryotic Translation Termination
397
set Eukaryotic Translation Termination
setSize 87
pANOVA 1.07e-07
s.dist 0.329
p.adjustANOVA 2.7e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928
RPL10L 17345
RPL34 17330
RPL27 17307
RPL23 17292
RPL18A 17183
RPS10 17181
RPL35A 17098
APEH 17003
RPS16 16779
RPL32 16664
RPS27A 16523
RPL24 16506
RPS28 16458
RPS14 16358
RPL17 16189
RPS29 16138
RPS9 16050
RPSA 16030
RPS19 15679

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPL10L 17345.0
RPL34 17330.0
RPL27 17307.0
RPL23 17292.0
RPL18A 17183.0
RPS10 17181.0
RPL35A 17098.0
APEH 17003.0
RPS16 16779.0
RPL32 16664.0
RPS27A 16523.0
RPL24 16506.0
RPS28 16458.0
RPS14 16358.0
RPL17 16189.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
RPL28 15605.0
RPL26L1 15561.5
RPL38 14997.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
RPL7 13881.0
RPL13A 13855.5
RPS27L 13689.0
RPS23 12899.0
RPS25 12714.5
RPL19 12327.0
RPS6 11935.0
RPL41 11601.0
N6AMT1 11257.0
RPS7 11217.0
RPL7A 11203.5
RPS8 10835.0
RPL3L 10775.0
ETF1 10700.0
RPL9 10376.0
RPLP2 10294.0
RPL36AL 9850.0
RPLP1 9499.0
RPS2 9470.5
RPL13 9381.5
RPL30 9189.0
RPL29 9040.0
RPS18 8661.0
RPL4 8015.0
RPL14 7987.0
RPL26 7877.0
RPS15 7536.0
RPL23A 7183.0
RPL12 7117.0
RPS5 6716.0
RPL21 6561.0
RPL8 6517.0
RPL37 6491.0
RPL37A 6372.0
GSPT1 6259.0
RPS15A 6158.0
RPL22 5299.0
UBA52 4986.0
RPS3A 4909.0
RPL22L1 4649.0
RPL3 4399.5
RPS3 4337.0
RPS13 4131.0
RPL5 2965.0
RPL31 2893.0
TRMT112 2583.5
RPS20 2265.0
RPL18 2245.0
RPL11 1692.0
RPL36 1435.0
RPL39L 484.0
RPL10A 307.0
RPLP0 -192.0
RPS12 -575.0
RPL35 -1039.0
RPL6 -1615.0
RPL15 -2406.5
RPL27A -3404.0
FAU -3698.0


Peptide chain elongation

Peptide chain elongation
903
set Peptide chain elongation
setSize 84
pANOVA 2.21e-07
s.dist 0.327
p.adjustANOVA 3.45e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928
RPL10L 17345
RPL34 17330
RPL27 17307
RPL23 17292
RPL18A 17183
RPS10 17181
RPL35A 17098
RPS16 16779
RPL32 16664
RPS27A 16523
RPL24 16506
RPS28 16458
RPS14 16358
RPL17 16189
RPS29 16138
RPS9 16050
RPSA 16030
RPS19 15679
RPL28 15605

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPL10L 17345.0
RPL34 17330.0
RPL27 17307.0
RPL23 17292.0
RPL18A 17183.0
RPS10 17181.0
RPL35A 17098.0
RPS16 16779.0
RPL32 16664.0
RPS27A 16523.0
RPL24 16506.0
RPS28 16458.0
RPS14 16358.0
RPL17 16189.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
RPL28 15605.0
RPL26L1 15561.5
EEF2 15497.5
RPL38 14997.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
RPL7 13881.0
RPL13A 13855.5
RPS27L 13689.0
RPS23 12899.0
RPS25 12714.5
RPL19 12327.0
RPS6 11935.0
RPL41 11601.0
RPS7 11217.0
RPL7A 11203.5
RPS8 10835.0
RPL3L 10775.0
RPL9 10376.0
RPLP2 10294.0
RPL36AL 9850.0
RPLP1 9499.0
RPS2 9470.5
RPL13 9381.5
RPL30 9189.0
RPL29 9040.0
RPS18 8661.0
RPL4 8015.0
RPL14 7987.0
RPL26 7877.0
RPS15 7536.0
RPL23A 7183.0
RPL12 7117.0
RPS5 6716.0
RPL21 6561.0
RPL8 6517.0
RPL37 6491.0
RPL37A 6372.0
RPS15A 6158.0
RPL22 5299.0
UBA52 4986.0
RPS3A 4909.0
RPL22L1 4649.0
RPL3 4399.5
RPS3 4337.0
RPS13 4131.0
RPL5 2965.0
RPL31 2893.0
RPS20 2265.0
RPL18 2245.0
RPL11 1692.0
RPL36 1435.0
EEF1A1 748.0
RPL39L 484.0
RPL10A 307.0
RPLP0 -192.0
RPS12 -575.0
RPL35 -1039.0
RPL6 -1615.0
RPL15 -2406.5
RPL27A -3404.0
FAU -3698.0


Regulation of IFNA/IFNB signaling

Regulation of IFNA/IFNB signaling
1086
set Regulation of IFNA/IFNB signaling
setSize 22
pANOVA 0.00814
s.dist -0.326
p.adjustANOVA 0.175



Top enriched genes

Top 20 genes
GeneID Gene Rank
IFNA6 -7468
IFNA16 -7435
IFNA2 -7322
IFNA21 -7163
IFNB1 -7151
IFNA14 -7144
IFNA1 -7016
IFNA5 -5642
IFNA7 -4213
PTPN11 -3314
STAT1 -2931
IFNA8 -2552
IFNAR2 3502
JAK1 4808
TYK2 7179
PTPN6 8314
PTPN1 8759
STAT2 8811
IFNAR1 10813
SOCS3 12384

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFNA6 -7468
IFNA16 -7435
IFNA2 -7322
IFNA21 -7163
IFNB1 -7151
IFNA14 -7144
IFNA1 -7016
IFNA5 -5642
IFNA7 -4213
PTPN11 -3314
STAT1 -2931
IFNA8 -2552
IFNAR2 3502
JAK1 4808
TYK2 7179
PTPN6 8314
PTPN1 8759
STAT2 8811
IFNAR1 10813
SOCS3 12384
SOCS1 15437
USP18 15611


Pexophagy

Pexophagy
910
set Pexophagy
setSize 11
pANOVA 0.0645
s.dist 0.322
p.adjustANOVA 0.608



Top enriched genes

Top 20 genes
GeneID Gene Rank
PEX5 16952
RPS27A 16523
NBR1 14948
UBC 13572
UBB 12753
MAP1LC3B 12681
ATM 11795
SQSTM1 6440
UBA52 4986
EPAS1 -89
USP30 -5787

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PEX5 16952
RPS27A 16523
NBR1 14948
UBC 13572
UBB 12753
MAP1LC3B 12681
ATM 11795
SQSTM1 6440
UBA52 4986
EPAS1 -89
USP30 -5787


Telomere C-strand synthesis initiation

Telomere C-strand synthesis initiation
1394
set Telomere C-strand synthesis initiation
setSize 11
pANOVA 0.0669
s.dist -0.319
p.adjustANOVA 0.617



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACD -4052.5
TERF1 -2922.0
POT1 -1335.0
POLA2 -633.0
TERF2 639.0
PRIM1 1086.0
PRIM2 2034.0
TERF2IP 2397.0
TINF2 4897.0
CTC1 5758.0
TEN1 6202.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACD -4052.5
TERF1 -2922.0
POT1 -1335.0
POLA2 -633.0
TERF2 639.0
PRIM1 1086.0
PRIM2 2034.0
TERF2IP 2397.0
TINF2 4897.0
CTC1 5758.0
TEN1 6202.5


p75NTR recruits signalling complexes

p75NTR recruits signalling complexes
1536
set p75NTR recruits signalling complexes
setSize 12
pANOVA 0.0557
s.dist 0.319
p.adjustANOVA 0.583



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 16523.0
UBC 13572.0
TRAF6 12950.0
UBB 12753.0
PRKCI 10853.0
MYD88 10683.0
NGF 9591.0
NGFR 8785.0
SQSTM1 6440.0
IKBKB 5090.0
UBA52 4986.0
RIPK2 1622.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 16523.0
UBC 13572.0
TRAF6 12950.0
UBB 12753.0
PRKCI 10853.0
MYD88 10683.0
NGF 9591.0
NGFR 8785.0
SQSTM1 6440.0
IKBKB 5090.0
UBA52 4986.0
RIPK2 1622.5


p75NTR signals via NF-kB

p75NTR signals via NF-kB
1537
set p75NTR signals via NF-kB
setSize 15
pANOVA 0.0327
s.dist 0.318
p.adjustANOVA 0.429



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 16523.0
NFKBIA 15601.0
UBC 13572.0
TRAF6 12950.0
UBB 12753.0
RELA 12174.0
PRKCI 10853.0
MYD88 10683.0
NGF 9591.0
NGFR 8785.0
SQSTM1 6440.0
IKBKB 5090.0
UBA52 4986.0
RIPK2 1622.5
NFKB1 571.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 16523.0
NFKBIA 15601.0
UBC 13572.0
TRAF6 12950.0
UBB 12753.0
RELA 12174.0
PRKCI 10853.0
MYD88 10683.0
NGF 9591.0
NGFR 8785.0
SQSTM1 6440.0
IKBKB 5090.0
UBA52 4986.0
RIPK2 1622.5
NFKB1 571.0


Intrinsic Pathway of Fibrin Clot Formation

Intrinsic Pathway of Fibrin Clot Formation
646
set Intrinsic Pathway of Fibrin Clot Formation
setSize 21
pANOVA 0.0115
s.dist -0.318
p.adjustANOVA 0.229



Top enriched genes

Top 20 genes
GeneID Gene Rank
PROS1 -6588
SERPINC1 -4940
GP5 -4342
GP1BA -3551
A2M -3529
SERPINE2 -3345
KLKB1 -2046
PRCP -1365
KNG1 -978
GP9 -235
SERPIND1 535
F10 1413
PROC 2747
C1QBP 3344
SERPING1 4245
F12 4865
SERPINA5 5251
F11 5906
GP1BB 7191
VWF 8926

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PROS1 -6588
SERPINC1 -4940
GP5 -4342
GP1BA -3551
A2M -3529
SERPINE2 -3345
KLKB1 -2046
PRCP -1365
KNG1 -978
GP9 -235
SERPIND1 535
F10 1413
PROC 2747
C1QBP 3344
SERPING1 4245
F12 4865
SERPINA5 5251
F11 5906
GP1BB 7191
VWF 8926
F2 13579


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
829
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 89
pANOVA 2.67e-07
s.dist 0.315
p.adjustANOVA 3.45e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928
RPL10L 17345
RPL34 17330
RPL27 17307
RPL23 17292
RPL18A 17183
RPS10 17181
RPL35A 17098
RPS16 16779
RPL32 16664
RPS27A 16523
RPL24 16506
RPS28 16458
RPS14 16358
RPL17 16189
RPS29 16138
RPS9 16050
RPSA 16030
RPS19 15679
RPL28 15605

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPL10L 17345.0
RPL34 17330.0
RPL27 17307.0
RPL23 17292.0
RPL18A 17183.0
RPS10 17181.0
RPL35A 17098.0
RPS16 16779.0
RPL32 16664.0
RPS27A 16523.0
RPL24 16506.0
RPS28 16458.0
RPS14 16358.0
RPL17 16189.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
RPL28 15605.0
RPL26L1 15561.5
RPL38 14997.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
RPL7 13881.0
RPL13A 13855.5
RPS27L 13689.0
EIF4G1 13084.0
RPS23 12899.0
RPS25 12714.5
RPL19 12327.0
RPS6 11935.0
RPL41 11601.0
RPS7 11217.0
RPL7A 11203.5
RPS8 10835.0
RPL3L 10775.0
ETF1 10700.0
RPL9 10376.0
RPLP2 10294.0
RPL36AL 9850.0
RPLP1 9499.0
RPS2 9470.5
RPL13 9381.5
RPL30 9189.0
RPL29 9040.0
RPS18 8661.0
PABPC1 8154.0
RPL4 8015.0
RPL14 7987.0
RPL26 7877.0
RPS15 7536.0
RPL23A 7183.0
RPL12 7117.0
UPF1 6830.0
RPS5 6716.0
RPL21 6561.0
RPL8 6517.0
RPL37 6491.0
RPL37A 6372.0
GSPT1 6259.0
RPS15A 6158.0
NCBP1 5667.0
RPL22 5299.0
UBA52 4986.0
RPS3A 4909.0
RPL22L1 4649.0
RPL3 4399.5
RPS3 4337.0
RPS13 4131.0
RPL5 2965.0
RPL31 2893.0
RPS20 2265.0
RPL18 2245.0
RPL11 1692.0
RPL36 1435.0
RPL39L 484.0
RPL10A 307.0
NCBP2 247.0
RPLP0 -192.0
RPS12 -575.0
RPL35 -1039.0
RPL6 -1615.0
RPL15 -2406.5
RPL27A -3404.0
FAU -3698.0


Selenocysteine synthesis

Selenocysteine synthesis
1208
set Selenocysteine synthesis
setSize 87
pANOVA 4.02e-07
s.dist 0.314
p.adjustANOVA 4.61e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928
RPL10L 17345
RPL34 17330
RPL27 17307
RPL23 17292
RPL18A 17183
RPS10 17181
RPL35A 17098
RPS16 16779
RPL32 16664
RPS27A 16523
RPL24 16506
RPS28 16458
RPS14 16358
RPL17 16189
RPS29 16138
RPS9 16050
RPSA 16030
RPS19 15679
RPL28 15605

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPL10L 17345.0
RPL34 17330.0
RPL27 17307.0
RPL23 17292.0
RPL18A 17183.0
RPS10 17181.0
RPL35A 17098.0
RPS16 16779.0
RPL32 16664.0
RPS27A 16523.0
RPL24 16506.0
RPS28 16458.0
RPS14 16358.0
RPL17 16189.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
RPL28 15605.0
RPL26L1 15561.5
RPL38 14997.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
RPL7 13881.0
RPL13A 13855.5
RPS27L 13689.0
RPS23 12899.0
RPS25 12714.5
RPL19 12327.0
RPS6 11935.0
RPL41 11601.0
RPS7 11217.0
RPL7A 11203.5
RPS8 10835.0
RPL3L 10775.0
RPL9 10376.0
RPLP2 10294.0
RPL36AL 9850.0
EEFSEC 9735.0
RPLP1 9499.0
RPS2 9470.5
RPL13 9381.5
RPL30 9189.0
RPL29 9040.0
RPS18 8661.0
RPL4 8015.0
RPL14 7987.0
RPL26 7877.0
RPS15 7536.0
SEPHS2 7289.0
RPL23A 7183.0
RPL12 7117.0
RPS5 6716.0
RPL21 6561.0
RPL8 6517.0
RPL37 6491.0
RPL37A 6372.0
RPS15A 6158.0
RPL22 5299.0
SEPSECS 5265.0
PSTK 5077.0
UBA52 4986.0
RPS3A 4909.0
RPL22L1 4649.0
RPL3 4399.5
RPS3 4337.0
RPS13 4131.0
SECISBP2 3413.0
RPL5 2965.0
RPL31 2893.0
RPS20 2265.0
RPL18 2245.0
RPL11 1692.0
RPL36 1435.0
RPL39L 484.0
RPL10A 307.0
RPLP0 -192.0
RPS12 -575.0
RPL35 -1039.0
RPL6 -1615.0
RPL15 -2406.5
RPL27A -3404.0
FAU -3698.0


Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
395
set Eukaryotic Translation Elongation
setSize 88
pANOVA 4.17e-07
s.dist 0.312
p.adjustANOVA 4.61e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928
RPL10L 17345
RPL34 17330
RPL27 17307
RPL23 17292
RPL18A 17183
RPS10 17181
RPL35A 17098
RPS16 16779
RPL32 16664
RPS27A 16523
RPL24 16506
RPS28 16458
RPS14 16358
RPL17 16189
RPS29 16138
RPS9 16050
RPSA 16030
RPS19 15679
RPL28 15605

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPL10L 17345.0
RPL34 17330.0
RPL27 17307.0
RPL23 17292.0
RPL18A 17183.0
RPS10 17181.0
RPL35A 17098.0
RPS16 16779.0
RPL32 16664.0
RPS27A 16523.0
RPL24 16506.0
RPS28 16458.0
RPS14 16358.0
RPL17 16189.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
RPL28 15605.0
RPL26L1 15561.5
EEF2 15497.5
RPL38 14997.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
RPL7 13881.0
RPL13A 13855.5
RPS27L 13689.0
RPS23 12899.0
RPS25 12714.5
RPL19 12327.0
RPS6 11935.0
RPL41 11601.0
RPS7 11217.0
RPL7A 11203.5
RPS8 10835.0
RPL3L 10775.0
EEF1D 10534.0
RPL9 10376.0
RPLP2 10294.0
RPL36AL 9850.0
RPLP1 9499.0
RPS2 9470.5
RPL13 9381.5
RPL30 9189.0
RPL29 9040.0
RPS18 8661.0
RPL4 8015.0
RPL14 7987.0
RPL26 7877.0
EEF1G 7745.0
RPS15 7536.0
RPL23A 7183.0
RPL12 7117.0
RPS5 6716.0
RPL21 6561.0
RPL8 6517.0
RPL37 6491.0
RPL37A 6372.0
RPS15A 6158.0
RPL22 5299.0
UBA52 4986.0
RPS3A 4909.0
RPL22L1 4649.0
RPL3 4399.5
RPS3 4337.0
RPS13 4131.0
EEF1A2 4115.0
RPL5 2965.0
RPL31 2893.0
RPS20 2265.0
RPL18 2245.0
RPL11 1692.0
RPL36 1435.0
EEF1A1 748.0
RPL39L 484.0
RPL10A 307.0
RPLP0 -192.0
RPS12 -575.0
EEF1B2 -960.0
RPL35 -1039.0
RPL6 -1615.0
RPL15 -2406.5
RPL27A -3404.0
FAU -3698.0


TRAF3-dependent IRF activation pathway

TRAF3-dependent IRF activation pathway
1383
set TRAF3-dependent IRF activation pathway
setSize 15
pANOVA 0.0368
s.dist -0.311
p.adjustANOVA 0.441



Top enriched genes

Top 20 genes
GeneID Gene Rank
IFNB1 -7151
TRIM4 -6997
SIKE1 -5193
DDX58 -3097
TBK1 -3086
EP300 -1077
TRIM25 -689
TRAF3 -490
MAVS 1150
CREBBP 1815
IRF3 6357
RNF135 7867
IFIH1 7936
IKBKE 10394
IRF7 12961

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFNB1 -7151
TRIM4 -6997
SIKE1 -5193
DDX58 -3097
TBK1 -3086
EP300 -1077
TRIM25 -689
TRAF3 -490
MAVS 1150
CREBBP 1815
IRF3 6357
RNF135 7867
IFIH1 7936
IKBKE 10394
IRF7 12961


Platelet Adhesion to exposed collagen

Platelet Adhesion to exposed collagen
929
set Platelet Adhesion to exposed collagen
setSize 13
pANOVA 0.0524
s.dist -0.311
p.adjustANOVA 0.569



Top enriched genes

Top 20 genes
GeneID Gene Rank
FCER1G -6019
GP6 -5420
LYN -4971
GP5 -4342
GP1BA -3551
FYN -3315
GP9 -235
ITGA10 910
ITGA1 5468
GP1BB 7191
VWF 8926
ITGB1 10814
ITGA2 12572

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FCER1G -6019
GP6 -5420
LYN -4971
GP5 -4342
GP1BA -3551
FYN -3315
GP9 -235
ITGA10 910
ITGA1 5468
GP1BB 7191
VWF 8926
ITGB1 10814
ITGA2 12572


SUMOylation of immune response proteins

SUMOylation of immune response proteins
1198
set SUMOylation of immune response proteins
setSize 10
pANOVA 0.0925
s.dist 0.307
p.adjustANOVA 0.673



Top enriched genes

Top 20 genes
GeneID Gene Rank
PIAS3 17371
NFKBIA 15601
RELA 12174
NFKB2 11668
IKBKE 10394
UBE2I 8613
TOPORS 7344
PIAS4 6354
SUMO1 2999
SUMO3 846

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIAS3 17371
NFKBIA 15601
RELA 12174
NFKB2 11668
IKBKE 10394
UBE2I 8613
TOPORS 7344
PIAS4 6354
SUMO1 2999
SUMO3 846


Metabolism of folate and pterines

Metabolism of folate and pterines
721
set Metabolism of folate and pterines
setSize 16
pANOVA 0.0341
s.dist -0.306
p.adjustANOVA 0.438



Top enriched genes

Top 20 genes
GeneID Gene Rank
MTHFS -5372
MTHFD2 -4969
MTHFD2L -4123
DHFR -3241
FOLR2 -2112
MTHFD1L -1006
MTHFD1 111
ALDH1L1 1046
SLC46A1 1126
SHMT1 1228
ALDH1L2 2746
SHMT2 4529
FPGS 5485
SLC25A32 5630
MTHFR 10439
SLC19A1 11687

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTHFS -5372
MTHFD2 -4969
MTHFD2L -4123
DHFR -3241
FOLR2 -2112
MTHFD1L -1006
MTHFD1 111
ALDH1L1 1046
SLC46A1 1126
SHMT1 1228
ALDH1L2 2746
SHMT2 4529
FPGS 5485
SLC25A32 5630
MTHFR 10439
SLC19A1 11687


Alpha-protein kinase 1 signaling pathway

Alpha-protein kinase 1 signaling pathway
70
set Alpha-protein kinase 1 signaling pathway
setSize 10
pANOVA 0.0969
s.dist 0.303
p.adjustANOVA 0.675



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAP3K7 17659
RPS27A 16523
UBC 13572
TRAF6 12950
UBB 12753
TIFA 9992
TAB1 7528
UBA52 4986
ALPK1 2214
TAB2 -5339

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAP3K7 17659
RPS27A 16523
UBC 13572
TRAF6 12950
UBB 12753
TIFA 9992
TAB1 7528
UBA52 4986
ALPK1 2214
TAB2 -5339


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
54
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 54
pANOVA 0.000148
s.dist 0.298
p.adjustANOVA 0.00655



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928
RPS10 17181
RPS16 16779
EIF3G 16747
RPS27A 16523
RPS28 16458
RPS14 16358
RPS29 16138
RPS9 16050
RPSA 16030
RPS19 15679
EIF3I 15333
RPS26 14854
RPS11 14847
RPS27 14838
RPS21 14082
RPS24 14073
EIF4A2 13943
RPS27L 13689
EIF4G1 13084

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPS10 17181.0
RPS16 16779.0
EIF3G 16747.0
RPS27A 16523.0
RPS28 16458.0
RPS14 16358.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
EIF3I 15333.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
EIF4A2 13943.0
RPS27L 13689.0
EIF4G1 13084.0
RPS23 12899.0
RPS25 12714.5
EIF3D 12117.0
RPS6 11935.0
RPS7 11217.0
EIF4B 10978.0
RPS8 10835.0
EIF3J 10022.0
EIF4EBP1 9749.0
RPS2 9470.5
RPS18 8661.0
EIF4E 8302.0
PABPC1 8154.0
RPS15 7536.0
EIF3E 7423.0
EIF4H 6966.0
RPS5 6716.0
RPS15A 6158.0
EIF4A1 5479.0
RPS3A 4909.0
RPS3 4337.0
RPS13 4131.0
EIF3L 3674.0
EIF2S1 2961.0
EIF3B 2802.0
EIF3F 2533.0
RPS20 2265.0
EIF3H 157.0
RPS12 -575.0
EIF2S2 -1094.0
EIF3K -2241.0
FAU -3698.0
EIF3M -4899.0
EIF3A -5567.0


Translation initiation complex formation

Translation initiation complex formation
1446
set Translation initiation complex formation
setSize 53
pANOVA 0.000178
s.dist 0.298
p.adjustANOVA 0.00764



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928
RPS10 17181
RPS16 16779
EIF3G 16747
RPS27A 16523
RPS28 16458
RPS14 16358
RPS29 16138
RPS9 16050
RPSA 16030
RPS19 15679
EIF3I 15333
RPS26 14854
RPS11 14847
RPS27 14838
RPS21 14082
RPS24 14073
EIF4A2 13943
RPS27L 13689
EIF4G1 13084

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPS10 17181.0
RPS16 16779.0
EIF3G 16747.0
RPS27A 16523.0
RPS28 16458.0
RPS14 16358.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
EIF3I 15333.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
EIF4A2 13943.0
RPS27L 13689.0
EIF4G1 13084.0
RPS23 12899.0
RPS25 12714.5
EIF3D 12117.0
RPS6 11935.0
RPS7 11217.0
EIF4B 10978.0
RPS8 10835.0
EIF3J 10022.0
RPS2 9470.5
RPS18 8661.0
EIF4E 8302.0
PABPC1 8154.0
RPS15 7536.0
EIF3E 7423.0
EIF4H 6966.0
RPS5 6716.0
RPS15A 6158.0
EIF4A1 5479.0
RPS3A 4909.0
RPS3 4337.0
RPS13 4131.0
EIF3L 3674.0
EIF2S1 2961.0
EIF3B 2802.0
EIF3F 2533.0
RPS20 2265.0
EIF3H 157.0
RPS12 -575.0
EIF2S2 -1094.0
EIF3K -2241.0
FAU -3698.0
EIF3M -4899.0
EIF3A -5567.0


Biosynthesis of DHA-derived SPMs

Biosynthesis of DHA-derived SPMs
125
set Biosynthesis of DHA-derived SPMs
setSize 17
pANOVA 0.0348
s.dist 0.296
p.adjustANOVA 0.438



Top enriched genes

Top 20 genes
GeneID Gene Rank
PTGS2 17390
CYP2E1 16999
CYP2D6 16570
ALOX12 16192
GPX4 15656
CYP3A4 15346
LTA4H 12808
HPGD 12543
CYP1A2 8917
ALOX5 8859
LTC4S 8623
ALOX15 7382
CYP1A1 5259
GSTM4 3097
EPHX2 341
CYP2C9 -4318
CYP2C8 -5503

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTGS2 17390
CYP2E1 16999
CYP2D6 16570
ALOX12 16192
GPX4 15656
CYP3A4 15346
LTA4H 12808
HPGD 12543
CYP1A2 8917
ALOX5 8859
LTC4S 8623
ALOX15 7382
CYP1A1 5259
GSTM4 3097
EPHX2 341
CYP2C9 -4318
CYP2C8 -5503


Pausing and recovery of Tat-mediated HIV elongation

Pausing and recovery of Tat-mediated HIV elongation
901
set Pausing and recovery of Tat-mediated HIV elongation
setSize 27
pANOVA 0.00816
s.dist 0.294
p.adjustANOVA 0.175



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2K 17670
POLR2J 17325
SUPT5H 17078
CDK9 16907
NELFB 15934
POLR2E 15207
CCNT1 13852
SSRP1 13740
ELL 13364
NELFE 12928
POLR2L 12768
POLR2G 11535
POLR2F 11524
POLR2D 11325
POLR2I 10998
NELFCD 10258
SUPT4H1 9057
TCEA1 8945
NELFA 6999
POLR2H 5804

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2K 17670
POLR2J 17325
SUPT5H 17078
CDK9 16907
NELFB 15934
POLR2E 15207
CCNT1 13852
SSRP1 13740
ELL 13364
NELFE 12928
POLR2L 12768
POLR2G 11535
POLR2F 11524
POLR2D 11325
POLR2I 10998
NELFCD 10258
SUPT4H1 9057
TCEA1 8945
NELFA 6999
POLR2H 5804
POLR2A 2766
GTF2F2 1608
POLR2B 172
POLR2C -1472
CTDP1 -1587
GTF2F1 -3495
SUPT16H -3766


Tat-mediated HIV elongation arrest and recovery

Tat-mediated HIV elongation arrest and recovery
1391
set Tat-mediated HIV elongation arrest and recovery
setSize 27
pANOVA 0.00816
s.dist 0.294
p.adjustANOVA 0.175



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2K 17670
POLR2J 17325
SUPT5H 17078
CDK9 16907
NELFB 15934
POLR2E 15207
CCNT1 13852
SSRP1 13740
ELL 13364
NELFE 12928
POLR2L 12768
POLR2G 11535
POLR2F 11524
POLR2D 11325
POLR2I 10998
NELFCD 10258
SUPT4H1 9057
TCEA1 8945
NELFA 6999
POLR2H 5804

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2K 17670
POLR2J 17325
SUPT5H 17078
CDK9 16907
NELFB 15934
POLR2E 15207
CCNT1 13852
SSRP1 13740
ELL 13364
NELFE 12928
POLR2L 12768
POLR2G 11535
POLR2F 11524
POLR2D 11325
POLR2I 10998
NELFCD 10258
SUPT4H1 9057
TCEA1 8945
NELFA 6999
POLR2H 5804
POLR2A 2766
GTF2F2 1608
POLR2B 172
POLR2C -1472
CTDP1 -1587
GTF2F1 -3495
SUPT16H -3766


Selenoamino acid metabolism

Selenoamino acid metabolism
1207
set Selenoamino acid metabolism
setSize 103
pANOVA 2.62e-07
s.dist 0.293
p.adjustANOVA 3.45e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928
RPL10L 17345
RPL34 17330
RPL27 17307
RPL23 17292
RPL18A 17183
RPS10 17181
RPL35A 17098
RPS16 16779
RPL32 16664
RPS27A 16523
RPL24 16506
RPS28 16458
RPS14 16358
RPL17 16189
RPS29 16138
RPS9 16050
RPSA 16030
RPS19 15679
RPL28 15605

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPL10L 17345.0
RPL34 17330.0
RPL27 17307.0
RPL23 17292.0
RPL18A 17183.0
RPS10 17181.0
RPL35A 17098.0
RPS16 16779.0
RPL32 16664.0
RPS27A 16523.0
RPL24 16506.0
RPS28 16458.0
RPS14 16358.0
RPL17 16189.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
RPL28 15605.0
RPL26L1 15561.5
GSR 15369.0
RPL38 14997.0
RPS26 14854.0
MAT1A 14850.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
RPL7 13881.0
RPL13A 13855.5
RPS27L 13689.0
PAPSS2 13191.0
RPS23 12899.0
RPS25 12714.5
RPL19 12327.0
RPS6 11935.0
GNMT 11828.0
AHCY 11748.0
RPL41 11601.0
RPS7 11217.0
RPL7A 11203.5
CBS 11070.0
RPS8 10835.0
RPL3L 10775.0
RPL9 10376.0
RPLP2 10294.0
EEF1E1 10008.0
RPL36AL 9850.0
EEFSEC 9735.0
RPLP1 9499.0
RPS2 9470.5
RPL13 9381.5
RPL30 9189.0
RPL29 9040.0
RPS18 8661.0
NNMT 8299.0
RPL4 8015.0
RPL14 7987.0
RPL26 7877.0
RPS15 7536.0
SEPHS2 7289.0
RPL23A 7183.0
RPL12 7117.0
RPS5 6716.0
RPL21 6561.0
RPL8 6517.0
RPL37 6491.0
TXNRD1 6407.0
RPL37A 6372.0
PAPSS1 6297.0
RPS15A 6158.0
HNMT 5720.0
RPL22 5299.0
SEPSECS 5265.0
PSTK 5077.0
UBA52 4986.0
RPS3A 4909.0
RPL22L1 4649.0
RPL3 4399.5
RPS3 4337.0
RPS13 4131.0
SECISBP2 3413.0
AIMP2 3119.0
RPL5 2965.0
AIMP1 2909.0
RPL31 2893.0
RPS20 2265.0
RPL18 2245.0
CTH 2035.0
RPL11 1692.0
RPL36 1435.0
INMT 650.0
RPL39L 484.0
RPL10A 307.0
RPLP0 -192.0
SCLY -516.0
RPS12 -575.0
RPL35 -1039.0
RPL6 -1615.0
RPL15 -2406.5
RPL27A -3404.0
FAU -3698.0


Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
455
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 46
pANOVA 0.000576
s.dist 0.293
p.adjustANOVA 0.0233



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928.0
RPS10 17181.0
RPS16 16779.0
EIF3G 16747.0
RPS27A 16523.0
RPS28 16458.0
RPS14 16358.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
EIF3I 15333.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
RPS27L 13689.0
RPS23 12899.0
RPS25 12714.5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPS10 17181.0
RPS16 16779.0
EIF3G 16747.0
RPS27A 16523.0
RPS28 16458.0
RPS14 16358.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
EIF3I 15333.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
RPS27L 13689.0
RPS23 12899.0
RPS25 12714.5
EIF3D 12117.0
RPS6 11935.0
RPS7 11217.0
RPS8 10835.0
EIF3J 10022.0
RPS2 9470.5
RPS18 8661.0
RPS15 7536.0
EIF3E 7423.0
RPS5 6716.0
RPS15A 6158.0
RPS3A 4909.0
RPS3 4337.0
RPS13 4131.0
EIF3L 3674.0
EIF2S1 2961.0
EIF3B 2802.0
EIF3F 2533.0
RPS20 2265.0
EIF3H 157.0
RPS12 -575.0
EIF2S2 -1094.0
EIF3K -2241.0
FAU -3698.0
EIF3M -4899.0
EIF3A -5567.0


SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery
1169
set SARS-CoV-2 modulates host translation machinery
setSize 46
pANOVA 0.000587
s.dist 0.293
p.adjustANOVA 0.0233



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928.0
RPS10 17181.0
GEMIN6 17164.0
RPS16 16779.0
GEMIN4 16532.0
RPS27A 16523.0
RPS28 16458.0
RPS14 16358.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
SNRPB 14437.5
RPS21 14082.0
RPS24 14073.0
SNRPE 13819.0
RPS27L 13689.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPS10 17181.0
GEMIN6 17164.0
RPS16 16779.0
GEMIN4 16532.0
RPS27A 16523.0
RPS28 16458.0
RPS14 16358.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
SNRPB 14437.5
RPS21 14082.0
RPS24 14073.0
SNRPE 13819.0
RPS27L 13689.0
RPS23 12899.0
RPS25 12714.5
RPS6 11935.0
RPS7 11217.0
RPS8 10835.0
RPS2 9470.5
SNRPD2 8748.0
RPS18 8661.0
RPS15 7536.0
RPS5 6716.0
RPS15A 6158.0
SNRPD3 5707.0
RPS3A 4909.0
SNRPD1 4550.0
RPS3 4337.0
RPS13 4131.0
RPS20 2265.0
SNRPG 1630.0
SNRPF 369.0
RPS12 -575.0
GEMIN5 -1013.0
FAU -3698.0
DDX20 -3847.0
GEMIN2 -5153.0
GEMIN7 -5868.0
SMN1 -7355.5


NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus
787
set NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize 11
pANOVA 0.0964
s.dist 0.289
p.adjustANOVA 0.675



Top enriched genes

Top 20 genes
GeneID Gene Rank
APH1B 17267
YWHAZ 15300
APH1A 15158
DLL4 13982
JAG1 10182
PSEN2 10125
ADAM10 6531
NOTCH4 6026
PSENEN 4324
PSEN1 1535
NCSTN -243

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APH1B 17267
YWHAZ 15300
APH1A 15158
DLL4 13982
JAG1 10182
PSEN2 10125
ADAM10 6531
NOTCH4 6026
PSENEN 4324
PSEN1 1535
NCSTN -243


STAT5 activation downstream of FLT3 ITD mutants

STAT5 activation downstream of FLT3 ITD mutants
1188
set STAT5 activation downstream of FLT3 ITD mutants
setSize 10
pANOVA 0.113
s.dist -0.289
p.adjustANOVA 0.701



Top enriched genes

Top 20 genes
GeneID Gene Rank
NOX4 -4403
GAB2 -3577
STAT5B -3526
PTPN11 -3314
FLT3 -2953
STAT5A -2524
GRB2 5702
BCL2L1 6626
CDKN1A 9088
PIM1 15521

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOX4 -4403
GAB2 -3577
STAT5B -3526
PTPN11 -3314
FLT3 -2953
STAT5A -2524
GRB2 5702
BCL2L1 6626
CDKN1A 9088
PIM1 15521


Receptor Mediated Mitophagy

Receptor Mediated Mitophagy
1065
set Receptor Mediated Mitophagy
setSize 10
pANOVA 0.113
s.dist 0.289
p.adjustANOVA 0.701



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSNK2A1 15819.0
SRC 15597.0
MAP1LC3B 12681.0
ATG12 11335.0
ULK1 10261.0
MAP1LC3A 10197.0
PGAM5 9388.0
CSNK2B 6917.5
ATG5 2301.0
CSNK2A2 -3460.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSNK2A1 15819.0
SRC 15597.0
MAP1LC3B 12681.0
ATG12 11335.0
ULK1 10261.0
MAP1LC3A 10197.0
PGAM5 9388.0
CSNK2B 6917.5
ATG5 2301.0
CSNK2A2 -3460.0


DAP12 interactions

DAP12 interactions
256
set DAP12 interactions
setSize 40
pANOVA 0.00156
s.dist -0.289
p.adjustANOVA 0.0536



Top enriched genes

Top 20 genes
GeneID Gene Rank
KLRC2 -7324
KLRK1 -6536
PIK3CB -6323
TREM2 -6249
SIGLEC14 -5757
TREM1 -5726
CD300LB -5380
CLEC5A -5190
SIRPB1 -4824
SOS1 -4576
KLRD1 -4335
TYROBP -3829
GRAP2 -3586
FYN -3315
HLA-E -2302
HLA-C -1817
LCP2 -1259
HLA-B -1136
SIGLEC16 262
PLCG2 1272

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KLRC2 -7324
KLRK1 -6536
PIK3CB -6323
TREM2 -6249
SIGLEC14 -5757
TREM1 -5726
CD300LB -5380
CLEC5A -5190
SIRPB1 -4824
SOS1 -4576
KLRD1 -4335
TYROBP -3829
GRAP2 -3586
FYN -3315
HLA-E -2302
HLA-C -1817
LCP2 -1259
HLA-B -1136
SIGLEC16 262
PLCG2 1272
SHC1 2027
SYK 2787
KIR2DS4 2937
KRAS 3589
VAV3 4129
B2M 5148
PIK3CA 5312
GRB2 5702
NRAS 6359
PIK3R1 6497
VAV2 6610
LCK 7358
RAC1 8519
SIGLEC15 9193
NCR2 9731
CD300E 10183
LAT 10400
PLCG1 11334
PIK3R2 12787
HRAS 14159


Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Activation of PPARGC1A (PGC-1alpha) by phosphorylation
46
set Activation of PPARGC1A (PGC-1alpha) by phosphorylation
setSize 10
pANOVA 0.116
s.dist 0.287
p.adjustANOVA 0.706



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKAA2 17065
PRKAG1 15990
PPARGC1A 15908
PRKAG3 13702
PRKAB1 13281
MAPK11 7550
PRKAG2 5531
MAPK12 3099
MAPK14 2376
PRKAB2 -3763

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKAA2 17065
PRKAG1 15990
PPARGC1A 15908
PRKAG3 13702
PRKAB1 13281
MAPK11 7550
PRKAG2 5531
MAPK12 3099
MAPK14 2376
PRKAB2 -3763


Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
1156
set Ribosomal scanning and start codon recognition
setSize 53
pANOVA 0.000312
s.dist 0.286
p.adjustANOVA 0.013



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17928
RPS10 17181
RPS16 16779
EIF3G 16747
RPS27A 16523
RPS28 16458
RPS14 16358
RPS29 16138
RPS9 16050
RPSA 16030
RPS19 15679
EIF3I 15333
RPS26 14854
RPS11 14847
RPS27 14838
RPS21 14082
RPS24 14073
EIF4A2 13943
RPS27L 13689
EIF4G1 13084

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17928.0
RPS10 17181.0
RPS16 16779.0
EIF3G 16747.0
RPS27A 16523.0
RPS28 16458.0
RPS14 16358.0
RPS29 16138.0
RPS9 16050.0
RPSA 16030.0
RPS19 15679.0
EIF3I 15333.0
RPS26 14854.0
RPS11 14847.0
RPS27 14838.0
RPS21 14082.0
RPS24 14073.0
EIF4A2 13943.0
RPS27L 13689.0
EIF4G1 13084.0
RPS23 12899.0
RPS25 12714.5
EIF3D 12117.0
RPS6 11935.0
RPS7 11217.0
EIF4B 10978.0
RPS8 10835.0
EIF3J 10022.0
RPS2 9470.5
RPS18 8661.0
EIF4E 8302.0
RPS15 7536.0
EIF3E 7423.0
EIF4H 6966.0
RPS5 6716.0
RPS15A 6158.0
EIF4A1 5479.0
RPS3A 4909.0
RPS3 4337.0
RPS13 4131.0
EIF3L 3674.0
EIF2S1 2961.0
EIF3B 2802.0
EIF3F 2533.0
RPS20 2265.0
EIF5 404.0
EIF3H 157.0
RPS12 -575.0
EIF2S2 -1094.0
EIF3K -2241.0
FAU -3698.0
EIF3M -4899.0
EIF3A -5567.0


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    parallel  stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.2.1                                    
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.4.3                                      
##  [4] reshape2_1.4.4                                     
##  [5] beeswarm_0.4.0                                     
##  [6] gplots_3.1.3                                       
##  [7] gtools_3.9.4                                       
##  [8] tibble_3.2.1                                       
##  [9] dplyr_1.1.3                                        
## [10] echarts4r_0.4.5                                    
## [11] ebGSEA_0.1.0                                       
## [12] globaltest_5.54.0                                  
## [13] survival_3.5-7                                     
## [14] tictoc_1.2                                         
## [15] RIdeogram_0.2.2                                    
## [16] eulerr_7.0.0                                       
## [17] kableExtra_1.3.4                                   
## [18] data.table_1.14.8                                  
## [19] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [20] minfi_1.46.0                                       
## [21] bumphunter_1.42.0                                  
## [22] locfit_1.5-9.8                                     
## [23] iterators_1.0.14                                   
## [24] foreach_1.5.2                                      
## [25] Biostrings_2.68.1                                  
## [26] XVector_0.40.0                                     
## [27] SummarizedExperiment_1.30.2                        
## [28] Biobase_2.60.0                                     
## [29] MatrixGenerics_1.12.3                              
## [30] matrixStats_1.0.0                                  
## [31] GenomicRanges_1.52.0                               
## [32] GenomeInfoDb_1.36.3                                
## [33] IRanges_2.34.1                                     
## [34] S4Vectors_0.38.1                                   
## [35] BiocGenerics_0.46.0                                
## [36] mitch_1.12.0                                       
## [37] limma_3.56.2                                       
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.3.1             later_1.3.1              
##   [3] BiocIO_1.10.0             bitops_1.0-7             
##   [5] filelock_1.0.2            preprocessCore_1.62.1    
##   [7] XML_3.99-0.14             lifecycle_1.0.3          
##   [9] lattice_0.21-8            MASS_7.3-60              
##  [11] base64_2.0.1              scrime_1.3.5             
##  [13] magrittr_2.0.3            sass_0.4.7               
##  [15] rmarkdown_2.24            jquerylib_0.1.4          
##  [17] yaml_2.3.7                httpuv_1.6.11            
##  [19] grImport2_0.2-0           doRNG_1.8.6              
##  [21] askpass_1.2.0             DBI_1.1.3                
##  [23] RColorBrewer_1.1-3        abind_1.4-5              
##  [25] zlibbioc_1.46.0           rvest_1.0.3              
##  [27] quadprog_1.5-8            purrr_1.0.2              
##  [29] RCurl_1.98-1.12           rappdirs_0.3.3           
##  [31] GenomeInfoDbData_1.2.10   genefilter_1.82.1        
##  [33] annotate_1.78.0           svglite_2.1.1            
##  [35] DelayedMatrixStats_1.22.6 codetools_0.2-19         
##  [37] DelayedArray_0.26.7       xml2_1.3.5               
##  [39] tidyselect_1.2.0          beanplot_1.3.1           
##  [41] base64enc_0.1-3           BiocFileCache_2.8.0      
##  [43] illuminaio_0.42.0         webshot_0.5.5            
##  [45] GenomicAlignments_1.36.0  jsonlite_1.8.7           
##  [47] multtest_2.56.0           ellipsis_0.3.2           
##  [49] systemfonts_1.0.4         tools_4.3.1              
##  [51] progress_1.2.2            Rcpp_1.0.11              
##  [53] glue_1.6.2                gridExtra_2.3            
##  [55] xfun_0.40                 HDF5Array_1.28.1         
##  [57] withr_2.5.0               fastmap_1.1.1            
##  [59] rhdf5filters_1.12.1       fansi_1.0.4              
##  [61] openssl_2.1.0             caTools_1.18.2           
##  [63] digest_0.6.33             R6_2.5.1                 
##  [65] mime_0.12                 colorspace_2.1-0         
##  [67] rsvg_2.4.0                jpeg_0.1-10              
##  [69] biomaRt_2.56.1            RSQLite_2.3.1            
##  [71] tidyr_1.3.0               utf8_1.2.3               
##  [73] generics_0.1.3            rtracklayer_1.60.1       
##  [75] prettyunits_1.1.1         httr_1.4.7               
##  [77] htmlwidgets_1.6.2         S4Arrays_1.0.6           
##  [79] pkgconfig_2.0.3           gtable_0.3.4             
##  [81] blob_1.2.4                siggenes_1.74.0          
##  [83] htmltools_0.5.6           scales_1.2.1             
##  [85] png_0.1-8                 knitr_1.44               
##  [87] rstudioapi_0.15.0         tzdb_0.4.0               
##  [89] rjson_0.2.21              nlme_3.1-163             
##  [91] curl_5.0.2                org.Hs.eg.db_3.17.0      
##  [93] cachem_1.0.8              rhdf5_2.44.0             
##  [95] stringr_1.5.0             KernSmooth_2.23-22       
##  [97] AnnotationDbi_1.62.2      restfulr_0.0.15          
##  [99] GEOquery_2.68.0           pillar_1.9.0             
## [101] grid_4.3.1                reshape_0.8.9            
## [103] vctrs_0.6.3               promises_1.2.1           
## [105] dbplyr_2.3.3              xtable_1.8-4             
## [107] evaluate_0.21             readr_2.1.4              
## [109] GenomicFeatures_1.52.2    cli_3.6.1                
## [111] compiler_4.3.1            Rsamtools_2.16.0         
## [113] rlang_1.1.1               crayon_1.5.2             
## [115] rngtools_1.5.2            kpmt_0.1.0               
## [117] nor1mix_1.3-0             mclust_6.0.0             
## [119] plyr_1.8.8                stringi_1.7.12           
## [121] viridisLite_0.4.2         BiocParallel_1.34.2      
## [123] munsell_0.5.0             Matrix_1.6-1             
## [125] hms_1.1.3                 sparseMatrixStats_1.12.2 
## [127] bit64_4.0.5               Rhdf5lib_1.22.1          
## [129] KEGGREST_1.40.0           shiny_1.7.5              
## [131] highr_0.10                memoise_2.0.1            
## [133] bslib_0.5.1               bit_4.0.5

END of report