date generated: 2024-10-08

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
bl gu
A1BG -0.1852624 -0.1294987
A1BG-AS1 -0.1441626 -0.0729665
A1CF -0.4179755 -0.4653975
A2M -0.8839529 -0.2984456
A2M-AS1 1.1227075 1.0645683
A2ML1 -0.4522837 -0.3052802

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 22269
duplicated_genes_present 0
num_profile_genes_in_sets 10596
num_profile_genes_not_in_sets 11673
profile_pearson_correl 0.18209
profile_spearman_correl 0.20741

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2694
num_genesets_excluded 1063
num_genesets_included 1631

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 520

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.bl s.gu p.bl p.gu
RNA Polymerase I Promoter Opening 26 1.16e-09 2.03e-08 0.795 0.632 0.481 2.39e-08 2.13e-05
Pexophagy 10 1.05e-03 4.81e-03 0.738 0.603 0.425 9.57e-04 2.00e-02
SIRT1 negatively regulates rRNA expression 30 1.68e-09 2.77e-08 0.733 0.584 0.442 2.99e-08 2.75e-05
Packaging Of Telomere Ends 29 6.57e-09 9.32e-08 0.722 0.549 0.469 3.01e-07 1.25e-05
Class C/3 (Metabotropic glutamate/pheromone receptors) 39 5.16e-11 1.20e-09 0.699 -0.507 -0.482 4.19e-08 1.93e-07
Assembly of the ORC complex at the origin of replication 32 1.11e-08 1.47e-07 0.679 0.477 0.484 3.05e-06 2.17e-06
DNA methylation 28 1.95e-07 1.81e-06 0.666 0.504 0.434 3.81e-06 6.92e-05
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 32 3.14e-08 3.77e-07 0.659 0.456 0.476 7.90e-06 3.13e-06
Defective pyroptosis 34 1.30e-08 1.68e-07 0.656 0.446 0.481 6.90e-06 1.19e-06
Deposition of new CENPA-containing nucleosomes at the centromere 46 2.88e-11 6.90e-10 0.652 0.475 0.447 2.48e-08 1.58e-07
Nucleosome assembly 46 2.88e-11 6.90e-10 0.652 0.475 0.447 2.48e-08 1.58e-07
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 29 2.42e-07 2.20e-06 0.651 0.463 0.457 1.56e-05 2.08e-05
Eicosanoids 12 1.99e-04 1.05e-03 0.650 0.639 -0.118 1.26e-04 4.81e-01
Inhibition of DNA recombination at telomere 43 2.00e-10 4.12e-09 0.640 0.535 0.352 1.27e-09 6.57e-05
SARS-CoV-1 modulates host translation machinery 34 2.43e-08 3.01e-07 0.633 0.551 0.311 2.67e-08 1.69e-03
Cleavage of the damaged pyrimidine 38 6.31e-09 9.11e-08 0.633 0.450 0.444 1.54e-06 2.13e-06
Depyrimidination 38 6.31e-09 9.11e-08 0.633 0.450 0.444 1.54e-06 2.13e-06
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 38 6.31e-09 9.11e-08 0.633 0.450 0.444 1.54e-06 2.13e-06
TICAM1-dependent activation of IRF3/IRF7 13 1.90e-03 7.98e-03 0.623 0.447 0.434 5.30e-03 6.70e-03
Scavenging of heme from plasma 12 3.27e-03 1.25e-02 0.620 -0.440 -0.436 8.24e-03 8.94e-03
Chromatin modifications during the maternal to zygotic transition (MZT) 32 2.49e-07 2.24e-06 0.617 0.483 0.384 2.26e-06 1.73e-04
Cleavage of the damaged purine 33 1.91e-07 1.80e-06 0.615 0.437 0.432 1.36e-05 1.76e-05
Depurination 33 1.91e-07 1.80e-06 0.615 0.437 0.432 1.36e-05 1.76e-05
Recognition and association of DNA glycosylase with site containing an affected purine 33 1.91e-07 1.80e-06 0.615 0.437 0.432 1.36e-05 1.76e-05
Sensory perception of sweet, bitter, and umami (glutamate) taste 41 4.38e-09 6.61e-08 0.613 -0.482 -0.379 9.39e-08 2.69e-05
Condensation of Prophase Chromosomes 36 6.52e-08 6.82e-07 0.608 0.452 0.406 2.64e-06 2.43e-05
Base-Excision Repair, AP Site Formation 40 1.16e-08 1.52e-07 0.607 0.412 0.445 6.57e-06 1.09e-06
Complex III assembly 24 1.54e-05 9.98e-05 0.601 0.313 0.513 7.91e-03 1.34e-05
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 7.54e-03 2.64e-02 0.598 0.431 0.414 1.33e-02 1.73e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 38 7.66e-08 7.86e-07 0.589 0.393 0.438 2.72e-05 2.89e-06
PRC2 methylates histones and DNA 35 2.60e-07 2.32e-06 0.589 0.363 0.463 2.01e-04 2.09e-06
Senescence-Associated Secretory Phenotype (SASP) 74 2.21e-14 8.86e-13 0.585 0.400 0.427 2.54e-09 2.13e-10
APC/C:Cdc20 mediated degradation of Cyclin B 24 4.35e-05 2.61e-04 0.574 0.310 0.483 8.52e-03 4.23e-05
PINK1-PRKN Mediated Mitophagy 31 3.93e-06 2.89e-05 0.568 0.366 0.434 4.20e-04 2.87e-05
B-WICH complex positively regulates rRNA expression 54 8.52e-10 1.53e-08 0.556 0.444 0.334 1.62e-08 2.22e-05
Diseases of programmed cell death 66 1.10e-11 2.85e-10 0.555 0.386 0.399 5.83e-08 2.02e-08
Assembly of the pre-replicative complex 105 3.92e-18 2.66e-16 0.555 0.382 0.403 1.37e-11 9.34e-13
Peptide chain elongation 84 3.13e-15 1.46e-13 0.554 0.488 0.262 9.66e-15 3.19e-05
Eukaryotic Translation Termination 87 1.05e-15 5.53e-14 0.553 0.490 0.256 2.69e-15 3.64e-05
SCF(Skp2)-mediated degradation of p27/p21 59 2.95e-10 5.80e-09 0.547 0.417 0.353 2.90e-08 2.71e-06
TICAM1,TRAF6-dependent induction of TAK1 complex 10 2.40e-02 7.08e-02 0.547 0.421 0.348 2.10e-02 5.66e-02
Formation of ATP by chemiosmotic coupling 18 1.26e-03 5.62e-03 0.547 0.385 0.388 4.70e-03 4.36e-03
Glucuronidation 24 1.39e-04 7.63e-04 0.545 -0.357 -0.412 2.45e-03 4.77e-04
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 11 1.62e-02 5.06e-02 0.544 0.452 0.303 9.44e-03 8.19e-02
Sensory perception of taste 47 3.47e-08 4.01e-07 0.543 -0.383 -0.385 5.68e-06 4.91e-06
Eukaryotic Translation Elongation 88 2.96e-15 1.42e-13 0.540 0.482 0.244 5.25e-15 7.38e-05
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 51 1.08e-08 1.46e-07 0.537 0.412 0.345 3.61e-07 1.97e-05
Viral mRNA Translation 84 3.03e-14 1.18e-12 0.536 0.469 0.259 9.91e-14 4.06e-05
Mitophagy 37 1.75e-06 1.38e-05 0.535 0.325 0.425 6.13e-04 7.83e-06
Selenocysteine synthesis 87 1.30e-14 5.42e-13 0.533 0.470 0.250 3.20e-14 5.46e-05


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.bl s.gu p.bl p.gu
RNA Polymerase I Promoter Opening 26 1.16e-09 2.03e-08 0.79500 6.32e-01 4.81e-01 2.39e-08 2.13e-05
Pexophagy 10 1.05e-03 4.81e-03 0.73800 6.03e-01 4.25e-01 9.57e-04 2.00e-02
SIRT1 negatively regulates rRNA expression 30 1.68e-09 2.77e-08 0.73300 5.84e-01 4.42e-01 2.99e-08 2.75e-05
Packaging Of Telomere Ends 29 6.57e-09 9.32e-08 0.72200 5.49e-01 4.69e-01 3.01e-07 1.25e-05
Class C/3 (Metabotropic glutamate/pheromone receptors) 39 5.16e-11 1.20e-09 0.69900 -5.07e-01 -4.82e-01 4.19e-08 1.93e-07
Assembly of the ORC complex at the origin of replication 32 1.11e-08 1.47e-07 0.67900 4.77e-01 4.84e-01 3.05e-06 2.17e-06
DNA methylation 28 1.95e-07 1.81e-06 0.66600 5.04e-01 4.34e-01 3.81e-06 6.92e-05
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 32 3.14e-08 3.77e-07 0.65900 4.56e-01 4.76e-01 7.90e-06 3.13e-06
Defective pyroptosis 34 1.30e-08 1.68e-07 0.65600 4.46e-01 4.81e-01 6.90e-06 1.19e-06
Deposition of new CENPA-containing nucleosomes at the centromere 46 2.88e-11 6.90e-10 0.65200 4.75e-01 4.47e-01 2.48e-08 1.58e-07
Nucleosome assembly 46 2.88e-11 6.90e-10 0.65200 4.75e-01 4.47e-01 2.48e-08 1.58e-07
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 29 2.42e-07 2.20e-06 0.65100 4.63e-01 4.57e-01 1.56e-05 2.08e-05
Eicosanoids 12 1.99e-04 1.05e-03 0.65000 6.39e-01 -1.18e-01 1.26e-04 4.81e-01
Inhibition of DNA recombination at telomere 43 2.00e-10 4.12e-09 0.64000 5.35e-01 3.52e-01 1.27e-09 6.57e-05
SARS-CoV-1 modulates host translation machinery 34 2.43e-08 3.01e-07 0.63300 5.51e-01 3.11e-01 2.67e-08 1.69e-03
Cleavage of the damaged pyrimidine 38 6.31e-09 9.11e-08 0.63300 4.50e-01 4.44e-01 1.54e-06 2.13e-06
Depyrimidination 38 6.31e-09 9.11e-08 0.63300 4.50e-01 4.44e-01 1.54e-06 2.13e-06
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 38 6.31e-09 9.11e-08 0.63300 4.50e-01 4.44e-01 1.54e-06 2.13e-06
TICAM1-dependent activation of IRF3/IRF7 13 1.90e-03 7.98e-03 0.62300 4.47e-01 4.34e-01 5.30e-03 6.70e-03
Scavenging of heme from plasma 12 3.27e-03 1.25e-02 0.62000 -4.40e-01 -4.36e-01 8.24e-03 8.94e-03
Chromatin modifications during the maternal to zygotic transition (MZT) 32 2.49e-07 2.24e-06 0.61700 4.83e-01 3.84e-01 2.26e-06 1.73e-04
Cleavage of the damaged purine 33 1.91e-07 1.80e-06 0.61500 4.37e-01 4.32e-01 1.36e-05 1.76e-05
Depurination 33 1.91e-07 1.80e-06 0.61500 4.37e-01 4.32e-01 1.36e-05 1.76e-05
Recognition and association of DNA glycosylase with site containing an affected purine 33 1.91e-07 1.80e-06 0.61500 4.37e-01 4.32e-01 1.36e-05 1.76e-05
Sensory perception of sweet, bitter, and umami (glutamate) taste 41 4.38e-09 6.61e-08 0.61300 -4.82e-01 -3.79e-01 9.39e-08 2.69e-05
Condensation of Prophase Chromosomes 36 6.52e-08 6.82e-07 0.60800 4.52e-01 4.06e-01 2.64e-06 2.43e-05
Base-Excision Repair, AP Site Formation 40 1.16e-08 1.52e-07 0.60700 4.12e-01 4.45e-01 6.57e-06 1.09e-06
Complex III assembly 24 1.54e-05 9.98e-05 0.60100 3.13e-01 5.13e-01 7.91e-03 1.34e-05
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 11 7.54e-03 2.64e-02 0.59800 4.31e-01 4.14e-01 1.33e-02 1.73e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 38 7.66e-08 7.86e-07 0.58900 3.93e-01 4.38e-01 2.72e-05 2.89e-06
PRC2 methylates histones and DNA 35 2.60e-07 2.32e-06 0.58900 3.63e-01 4.63e-01 2.01e-04 2.09e-06
Senescence-Associated Secretory Phenotype (SASP) 74 2.21e-14 8.86e-13 0.58500 4.00e-01 4.27e-01 2.54e-09 2.13e-10
APC/C:Cdc20 mediated degradation of Cyclin B 24 4.35e-05 2.61e-04 0.57400 3.10e-01 4.83e-01 8.52e-03 4.23e-05
PINK1-PRKN Mediated Mitophagy 31 3.93e-06 2.89e-05 0.56800 3.66e-01 4.34e-01 4.20e-04 2.87e-05
B-WICH complex positively regulates rRNA expression 54 8.52e-10 1.53e-08 0.55600 4.44e-01 3.34e-01 1.62e-08 2.22e-05
Diseases of programmed cell death 66 1.10e-11 2.85e-10 0.55500 3.86e-01 3.99e-01 5.83e-08 2.02e-08
Assembly of the pre-replicative complex 105 3.92e-18 2.66e-16 0.55500 3.82e-01 4.03e-01 1.37e-11 9.34e-13
Peptide chain elongation 84 3.13e-15 1.46e-13 0.55400 4.88e-01 2.62e-01 9.66e-15 3.19e-05
Eukaryotic Translation Termination 87 1.05e-15 5.53e-14 0.55300 4.90e-01 2.56e-01 2.69e-15 3.64e-05
SCF(Skp2)-mediated degradation of p27/p21 59 2.95e-10 5.80e-09 0.54700 4.17e-01 3.53e-01 2.90e-08 2.71e-06
TICAM1,TRAF6-dependent induction of TAK1 complex 10 2.40e-02 7.08e-02 0.54700 4.21e-01 3.48e-01 2.10e-02 5.66e-02
Formation of ATP by chemiosmotic coupling 18 1.26e-03 5.62e-03 0.54700 3.85e-01 3.88e-01 4.70e-03 4.36e-03
Glucuronidation 24 1.39e-04 7.63e-04 0.54500 -3.57e-01 -4.12e-01 2.45e-03 4.77e-04
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 11 1.62e-02 5.06e-02 0.54400 4.52e-01 3.03e-01 9.44e-03 8.19e-02
Sensory perception of taste 47 3.47e-08 4.01e-07 0.54300 -3.83e-01 -3.85e-01 5.68e-06 4.91e-06
Eukaryotic Translation Elongation 88 2.96e-15 1.42e-13 0.54000 4.82e-01 2.44e-01 5.25e-15 7.38e-05
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 51 1.08e-08 1.46e-07 0.53700 4.12e-01 3.45e-01 3.61e-07 1.97e-05
Viral mRNA Translation 84 3.03e-14 1.18e-12 0.53600 4.69e-01 2.59e-01 9.91e-14 4.06e-05
Mitophagy 37 1.75e-06 1.38e-05 0.53500 3.25e-01 4.25e-01 6.13e-04 7.83e-06
Selenocysteine synthesis 87 1.30e-14 5.42e-13 0.53300 4.70e-01 2.50e-01 3.20e-14 5.46e-05
RNA Polymerase I Promoter Escape 53 6.41e-09 9.17e-08 0.53300 4.28e-01 3.17e-01 6.99e-08 6.44e-05
CASP8 activity is inhibited 11 1.50e-02 4.72e-02 0.53200 4.97e-01 1.92e-01 4.34e-03 2.71e-01
Dimerization of procaspase-8 11 1.50e-02 4.72e-02 0.53200 4.97e-01 1.92e-01 4.34e-03 2.71e-01
Regulation by c-FLIP 11 1.50e-02 4.72e-02 0.53200 4.97e-01 1.92e-01 4.34e-03 2.71e-01
DNA Replication Pre-Initiation 120 5.41e-19 4.20e-17 0.53200 3.70e-01 3.83e-01 2.54e-12 4.37e-13
Autodegradation of Cdh1 by Cdh1:APC/C 63 3.15e-10 6.12e-09 0.52900 3.71e-01 3.78e-01 3.56e-07 2.16e-07
TICAM1, RIP1-mediated IKK complex recruitment 18 1.92e-03 8.05e-03 0.52900 3.58e-01 3.89e-01 8.57e-03 4.25e-03
DNA Damage/Telomere Stress Induced Senescence 57 2.80e-09 4.39e-08 0.52800 3.91e-01 3.54e-01 3.32e-07 3.67e-06
Replacement of protamines by nucleosomes in the male pronucleus 22 3.48e-04 1.79e-03 0.52600 4.72e-01 2.30e-01 1.25e-04 6.15e-02
Digestion 18 1.86e-03 7.80e-03 0.52500 -2.93e-01 -4.36e-01 3.15e-02 1.35e-03
Autodegradation of the E3 ubiquitin ligase COP1 50 2.75e-08 3.37e-07 0.52500 4.36e-01 2.92e-01 9.70e-08 3.48e-04
Stabilization of p53 55 7.33e-09 1.02e-07 0.52200 4.15e-01 3.15e-01 9.81e-08 5.19e-05
Transcriptional regulation of granulopoiesis 53 1.10e-08 1.47e-07 0.52000 2.65e-01 4.47e-01 8.30e-04 1.80e-08
Defective C1GALT1C1 causes TNPS 18 2.43e-03 9.69e-03 0.51900 -3.83e-01 -3.51e-01 4.96e-03 1.00e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 54 1.04e-08 1.43e-07 0.51900 4.32e-01 2.87e-01 4.02e-08 2.58e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 51 3.35e-08 3.90e-07 0.51800 4.19e-01 3.05e-01 2.22e-07 1.64e-04
p53-Independent DNA Damage Response 51 3.35e-08 3.90e-07 0.51800 4.19e-01 3.05e-01 2.22e-07 1.64e-04
p53-Independent G1/S DNA damage checkpoint 51 3.35e-08 3.90e-07 0.51800 4.19e-01 3.05e-01 2.22e-07 1.64e-04
Formation of the posterior neural plate 10 1.27e-02 4.11e-02 0.51800 -4.68e-02 5.16e-01 7.98e-01 4.72e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs 91 8.34e-14 2.78e-12 0.51700 3.77e-01 3.54e-01 5.22e-10 5.35e-09
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 89 4.52e-14 1.71e-12 0.51700 4.56e-01 2.44e-01 1.05e-13 7.12e-05
Response of EIF2AK4 (GCN2) to amino acid deficiency 95 7.85e-15 3.37e-13 0.51500 4.51e-01 2.49e-01 2.92e-14 2.77e-05
Hh mutants are degraded by ERAD 55 1.25e-08 1.63e-07 0.51500 4.01e-01 3.23e-01 2.63e-07 3.43e-05
APC-Cdc20 mediated degradation of Nek2A 26 1.67e-04 8.95e-04 0.51100 2.61e-01 4.39e-01 2.11e-02 1.05e-04
Complex IV assembly 44 6.71e-07 5.59e-06 0.51000 3.64e-01 3.58e-01 2.98e-05 3.97e-05
Condensation of Prometaphase Chromosomes 11 1.86e-02 5.70e-02 0.51000 1.40e-01 4.90e-01 4.21e-01 4.89e-03
Ubiquitin-dependent degradation of Cyclin D 51 6.12e-08 6.53e-07 0.50800 4.16e-01 2.92e-01 2.70e-07 3.07e-04
APC/C:Cdc20 mediated degradation of Securin 67 4.55e-10 8.54e-09 0.50800 3.81e-01 3.37e-01 6.81e-08 1.89e-06
Mitochondrial iron-sulfur cluster biogenesis 13 1.42e-02 4.53e-02 0.50800 2.78e-01 4.25e-01 8.24e-02 7.98e-03
Apoptosis induced DNA fragmentation 13 1.49e-02 4.72e-02 0.50700 4.15e-01 2.92e-01 9.65e-03 6.88e-02
Defective GALNT3 causes HFTC 18 3.23e-03 1.24e-02 0.50600 -3.79e-01 -3.35e-01 5.32e-03 1.39e-02
Josephin domain DUBs 10 3.86e-02 1.06e-01 0.50500 2.69e-01 4.28e-01 1.41e-01 1.91e-02
Expression and translocation of olfactory receptors 355 5.19e-50 4.23e-47 0.50500 -2.83e-01 -4.18e-01 4.12e-20 5.82e-42
Regulation of endogenous retroelements by KRAB-ZFP proteins 70 2.37e-10 4.77e-09 0.50400 3.25e-01 3.86e-01 2.58e-06 2.33e-08
Phosphorylation of the APC/C 20 1.34e-03 5.91e-03 0.50400 2.30e-01 4.48e-01 7.47e-02 5.18e-04
Defective GALNT12 causes CRCS1 18 3.49e-03 1.33e-02 0.50300 -3.77e-01 -3.33e-01 5.65e-03 1.45e-02
Negative regulation of NOTCH4 signaling 53 5.64e-08 6.13e-07 0.50200 3.92e-01 3.15e-01 8.07e-07 7.38e-05
Vpu mediated degradation of CD4 51 1.03e-07 1.03e-06 0.50200 3.97e-01 3.08e-01 9.39e-07 1.42e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 73 1.20e-10 2.67e-09 0.50200 3.71e-01 3.38e-01 4.13e-08 5.73e-07
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 1.79e-04 9.56e-04 0.50100 2.70e-01 4.22e-01 1.50e-02 1.46e-04
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 16 6.03e-04 3.00e-03 0.50000 -4.26e-01 2.61e-01 3.19e-03 7.01e-02
Aspirin ADME 43 1.15e-06 9.27e-06 0.49800 -2.53e-01 -4.29e-01 4.08e-03 1.11e-06
SRP-dependent cotranslational protein targeting to membrane 106 1.69e-15 8.35e-14 0.49800 4.41e-01 2.31e-01 4.23e-15 4.03e-05
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 54 5.00e-08 5.55e-07 0.49700 4.07e-01 2.86e-01 2.31e-07 2.78e-04
SCF-beta-TrCP mediated degradation of Emi1 54 6.23e-08 6.55e-07 0.49700 3.84e-01 3.15e-01 1.07e-06 6.17e-05
Olfactory Signaling Pathway 362 2.82e-49 1.53e-46 0.49600 -2.74e-01 -4.14e-01 3.48e-19 6.98e-42
Formation of a pool of free 40S subunits 94 8.87e-14 2.89e-12 0.49500 4.43e-01 2.20e-01 1.04e-13 2.29e-04
Regulation of activated PAK-2p34 by proteasome mediated degradation 49 2.81e-07 2.49e-06 0.49500 4.02e-01 2.88e-01 1.09e-06 4.93e-04
p53-Dependent G1 DNA Damage Response 64 3.69e-09 5.62e-08 0.49400 3.76e-01 3.20e-01 1.97e-07 9.23e-06
p53-Dependent G1/S DNA damage checkpoint 64 3.69e-09 5.62e-08 0.49400 3.76e-01 3.20e-01 1.97e-07 9.23e-06
RIPK1-mediated regulated necrosis 29 1.57e-04 8.47e-04 0.49300 3.40e-01 3.58e-01 1.55e-03 8.53e-04
Regulation of necroptotic cell death 29 1.57e-04 8.47e-04 0.49300 3.40e-01 3.58e-01 1.55e-03 8.53e-04
NoRC negatively regulates rRNA expression 68 1.36e-09 2.28e-08 0.49200 3.43e-01 3.53e-01 9.71e-07 4.91e-07
Vif-mediated degradation of APOBEC3G 53 8.95e-08 9.12e-07 0.49100 4.12e-01 2.68e-01 2.12e-07 7.32e-04
TNFR1-induced proapoptotic signaling 24 7.51e-04 3.65e-03 0.49100 3.47e-01 3.48e-01 3.26e-03 3.16e-03
G1/S DNA Damage Checkpoints 66 2.74e-09 4.34e-08 0.49000 3.73e-01 3.18e-01 1.59e-07 7.91e-06
Apoptotic cleavage of cell adhesion proteins 11 3.57e-02 9.90e-02 0.48800 -4.11e-01 -2.62e-01 1.81e-02 1.32e-01
CDK-mediated phosphorylation and removal of Cdc6 72 6.94e-10 1.27e-08 0.48600 3.45e-01 3.43e-01 4.15e-07 4.94e-07
Regulation of RUNX3 expression and activity 54 1.40e-07 1.37e-06 0.48400 3.74e-01 3.08e-01 1.98e-06 9.17e-05
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 2.03e-03 8.30e-03 0.48400 2.00e-01 4.41e-01 1.22e-01 6.34e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 72 8.05e-10 1.46e-08 0.48400 3.58e-01 3.26e-01 1.52e-07 1.68e-06
Transcriptional regulation by small RNAs 70 1.57e-09 2.62e-08 0.48300 3.26e-01 3.56e-01 2.31e-06 2.54e-07
Early Phase of HIV Life Cycle 14 1.20e-02 3.93e-02 0.48300 1.68e-01 4.52e-01 2.75e-01 3.37e-03
Positive epigenetic regulation of rRNA expression 68 3.26e-09 5.06e-08 0.48100 3.51e-01 3.29e-01 5.38e-07 2.69e-06
Membrane binding and targetting of GAG proteins 14 1.05e-02 3.53e-02 0.48100 1.23e-01 4.65e-01 4.24e-01 2.58e-03
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 1.05e-02 3.53e-02 0.48100 1.23e-01 4.65e-01 4.24e-01 2.58e-03
SARS-CoV-2 modulates host translation machinery 46 1.15e-06 9.27e-06 0.48100 4.17e-01 2.40e-01 9.90e-07 4.84e-03
Hh mutants abrogate ligand secretion 58 5.41e-08 5.93e-07 0.48100 3.75e-01 3.01e-01 7.63e-07 7.45e-05
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 76 3.70e-10 7.09e-09 0.48000 3.45e-01 3.34e-01 2.03e-07 4.61e-07
Negative epigenetic regulation of rRNA expression 70 2.29e-09 3.69e-08 0.47900 3.37e-01 3.41e-01 1.10e-06 8.31e-07
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 73 9.70e-10 1.72e-08 0.47900 3.51e-01 3.25e-01 2.09e-07 1.53e-06
APC/C:Cdc20 mediated degradation of mitotic proteins 75 5.69e-10 1.05e-08 0.47900 3.43e-01 3.33e-01 2.69e-07 5.97e-07
Cross-presentation of soluble exogenous antigens (endosomes) 47 1.02e-06 8.31e-06 0.47800 4.14e-01 2.40e-01 9.12e-07 4.45e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 104 5.28e-14 1.87e-12 0.47500 4.25e-01 2.13e-01 6.94e-14 1.76e-04
Assembly Of The HIV Virion 16 6.25e-03 2.23e-02 0.47300 1.11e-01 4.60e-01 4.42e-01 1.45e-03
STAT5 activation downstream of FLT3 ITD mutants 10 5.70e-02 1.44e-01 0.47300 2.40e-01 4.07e-01 1.88e-01 2.58e-02
HDACs deacetylate histones 55 2.47e-07 2.24e-06 0.47200 3.36e-01 3.32e-01 1.65e-05 2.01e-05
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 2.76e-03 1.08e-02 0.47000 1.85e-01 4.32e-01 1.51e-01 8.13e-04
L13a-mediated translational silencing of Ceruloplasmin expression 103 1.19e-13 3.81e-12 0.47000 4.23e-01 2.04e-01 1.11e-13 3.46e-04
Formation of the ternary complex, and subsequently, the 43S complex 46 1.77e-06 1.38e-05 0.46900 4.21e-01 2.06e-01 7.63e-07 1.54e-02
DNA Replication 148 3.35e-18 2.48e-16 0.46900 3.31e-01 3.32e-01 3.48e-12 2.97e-12
Regulation of APC/C activators between G1/S and early anaphase 80 3.87e-10 7.34e-09 0.46700 3.18e-01 3.42e-01 8.44e-07 1.20e-07
SARS-CoV-1 activates/modulates innate immune responses 39 1.58e-05 1.03e-04 0.46700 2.17e-01 4.14e-01 1.93e-02 7.66e-06
Degradation of DVL 56 2.60e-07 2.32e-06 0.46500 3.72e-01 2.79e-01 1.47e-06 3.05e-04
GLI3 is processed to GLI3R by the proteasome 59 1.14e-07 1.13e-06 0.46500 3.75e-01 2.75e-01 6.46e-07 2.55e-04
Cap-dependent Translation Initiation 111 4.85e-14 1.76e-12 0.46100 4.12e-01 2.07e-01 6.49e-14 1.70e-04
Eukaryotic Translation Initiation 111 4.85e-14 1.76e-12 0.46100 4.12e-01 2.07e-01 6.49e-14 1.70e-04
Dectin-2 family 28 5.02e-04 2.53e-03 0.46000 -3.95e-01 -2.36e-01 2.92e-04 3.07e-02
Defective CFTR causes cystic fibrosis 60 1.17e-07 1.16e-06 0.46000 3.72e-01 2.70e-01 6.00e-07 2.90e-04
Degradation of GLI2 by the proteasome 59 1.51e-07 1.46e-06 0.46000 3.76e-01 2.65e-01 5.81e-07 4.37e-04
APC/C-mediated degradation of cell cycle proteins 87 1.27e-10 2.75e-09 0.46000 3.17e-01 3.33e-01 3.14e-07 7.95e-08
Regulation of mitotic cell cycle 87 1.27e-10 2.75e-09 0.46000 3.17e-01 3.33e-01 3.14e-07 7.95e-08
Suppression of phagosomal maturation 13 3.34e-02 9.30e-02 0.45900 3.36e-01 3.13e-01 3.62e-02 5.07e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 4.73e-05 2.81e-04 0.45600 1.81e-01 4.19e-01 6.05e-02 1.36e-05
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 108 2.89e-13 8.89e-12 0.45500 4.01e-01 2.15e-01 5.86e-13 1.15e-04
Nonsense-Mediated Decay (NMD) 108 2.89e-13 8.89e-12 0.45500 4.01e-01 2.15e-01 5.86e-13 1.15e-04
Switching of origins to a post-replicative state 91 7.22e-11 1.63e-09 0.45500 2.99e-01 3.42e-01 7.83e-07 1.67e-08
Interaction With Cumulus Cells And The Zona Pellucida 11 2.45e-02 7.17e-02 0.45500 4.58e-02 -4.52e-01 7.93e-01 9.38e-03
Prednisone ADME 10 8.01e-02 1.86e-01 0.45100 -3.18e-01 -3.20e-01 8.18e-02 8.00e-02
Digestion and absorption 23 2.96e-03 1.16e-02 0.45100 -2.87e-01 -3.47e-01 1.72e-02 3.92e-03
Regulation of ornithine decarboxylase (ODC) 50 3.35e-06 2.53e-05 0.44900 3.54e-01 2.77e-01 1.51e-05 7.01e-04
rRNA processing in the nucleus and cytosol 182 6.90e-21 6.25e-19 0.44900 3.80e-01 2.38e-01 8.36e-19 2.92e-08
Influenza Viral RNA Transcription and Replication 131 5.25e-15 2.38e-13 0.44800 3.57e-01 2.71e-01 1.61e-12 8.49e-08
Inactivation of APC/C via direct inhibition of the APC/C complex 21 3.83e-03 1.43e-02 0.44800 1.86e-01 4.08e-01 1.40e-01 1.22e-03
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 3.83e-03 1.43e-02 0.44800 1.86e-01 4.08e-01 1.40e-01 1.22e-03
Major pathway of rRNA processing in the nucleolus and cytosol 173 5.26e-20 4.29e-18 0.44800 3.88e-01 2.23e-01 1.15e-18 4.01e-07
HCMV Late Events 82 1.32e-09 2.24e-08 0.44600 2.62e-01 3.61e-01 4.13e-05 1.60e-08
Thyroxine biosynthesis 10 8.24e-02 1.90e-01 0.44500 -3.66e-01 -2.52e-01 4.50e-02 1.67e-01
Degradation of GLI1 by the proteasome 59 4.92e-07 4.25e-06 0.44400 3.46e-01 2.79e-01 4.38e-06 2.07e-04
NIK–>noncanonical NF-kB signaling 58 6.46e-07 5.40e-06 0.44300 3.50e-01 2.72e-01 3.92e-06 3.42e-04
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 1.52e-07 1.46e-06 0.44300 3.54e-01 2.65e-01 9.30e-07 2.46e-04
Activation of RAC1 12 3.41e-02 9.48e-02 0.44200 -4.33e-01 -8.86e-02 9.32e-03 5.95e-01
Diseases of mitotic cell cycle 37 7.44e-05 4.22e-04 0.44200 1.86e-01 4.01e-01 5.06e-02 2.46e-05
MET activates RAS signaling 11 1.81e-02 5.58e-02 0.44100 -2.52e-01 3.62e-01 1.48e-01 3.74e-02
Influenza Infection 150 1.98e-16 1.07e-14 0.44100 3.39e-01 2.82e-01 7.76e-13 2.49e-09
Orc1 removal from chromatin 70 4.88e-08 5.45e-07 0.44000 3.23e-01 2.99e-01 2.95e-06 1.48e-05
Dectin-1 mediated noncanonical NF-kB signaling 61 4.32e-07 3.77e-06 0.43800 3.50e-01 2.64e-01 2.31e-06 3.63e-04
Regulation of expression of SLITs and ROBOs 162 6.14e-18 4.01e-16 0.43800 3.77e-01 2.23e-01 1.15e-16 9.82e-07
rRNA processing 191 1.22e-20 1.05e-18 0.43600 3.66e-01 2.36e-01 2.28e-18 1.80e-08
Selenoamino acid metabolism 110 2.64e-12 7.29e-11 0.43600 3.74e-01 2.25e-01 1.25e-11 4.70e-05
cGMP effects 16 9.82e-03 3.34e-02 0.43600 -3.08e-02 -4.35e-01 8.31e-01 2.60e-03
Regulation of Apoptosis 52 4.32e-06 3.13e-05 0.43500 3.51e-01 2.57e-01 1.21e-05 1.32e-03
Metabolism of polyamines 56 1.70e-06 1.34e-05 0.43400 3.58e-01 2.45e-01 3.61e-06 1.52e-03
Mitochondrial RNA degradation 10 8.65e-02 1.97e-01 0.43300 1.96e-01 3.86e-01 2.82e-01 3.45e-02
Meiotic recombination 52 5.35e-06 3.83e-05 0.43300 3.32e-01 2.77e-01 3.35e-05 5.39e-04
Androgen biosynthesis 11 4.98e-02 1.30e-01 0.43200 -7.12e-02 -4.26e-01 6.83e-01 1.44e-02
Regulation of innate immune responses to cytosolic DNA 15 3.06e-02 8.67e-02 0.43100 3.44e-01 2.59e-01 2.10e-02 8.27e-02
Spry regulation of FGF signaling 16 2.40e-02 7.08e-02 0.42900 2.36e-01 3.58e-01 1.02e-01 1.32e-02
RNA Polymerase I Promoter Clearance 71 1.00e-07 1.01e-06 0.42800 3.01e-01 3.04e-01 1.12e-05 9.46e-06
RNA Polymerase I Transcription 71 1.00e-07 1.01e-06 0.42800 3.01e-01 3.04e-01 1.12e-05 9.46e-06
Class I peroxisomal membrane protein import 19 1.26e-02 4.08e-02 0.42600 3.55e-01 2.36e-01 7.34e-03 7.54e-02
Regulation of TP53 Activity through Methylation 19 1.39e-02 4.48e-02 0.42600 2.96e-01 3.06e-01 2.54e-02 2.11e-02
NF-kB is activated and signals survival 12 5.63e-02 1.43e-01 0.42500 3.88e-01 1.74e-01 1.99e-02 2.96e-01
Chromosome Maintenance 109 2.44e-11 6.02e-10 0.42500 3.13e-01 2.88e-01 1.67e-08 1.94e-07
The role of GTSE1 in G2/M progression after G2 checkpoint 76 3.30e-08 3.90e-07 0.42500 3.41e-01 2.54e-01 2.71e-07 1.26e-04
Somitogenesis 54 4.66e-06 3.34e-05 0.42500 3.46e-01 2.47e-01 1.09e-05 1.67e-03
SARS-CoV-1-host interactions 92 1.18e-09 2.04e-08 0.42500 2.96e-01 3.05e-01 9.30e-07 4.28e-07
Ribosomal scanning and start codon recognition 53 3.46e-06 2.59e-05 0.42500 3.85e-01 1.80e-01 1.25e-06 2.37e-02
Carnitine metabolism 13 1.40e-02 4.50e-02 0.42400 -3.78e-01 1.91e-01 1.81e-02 2.34e-01
Respiratory electron transport 142 2.23e-14 8.86e-13 0.42300 2.82e-01 3.15e-01 6.39e-09 8.95e-11
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 18 1.49e-02 4.72e-02 0.42200 1.87e-01 3.79e-01 1.70e-01 5.37e-03
Activation of the TFAP2 (AP-2) family of transcription factors 11 8.41e-02 1.93e-01 0.42100 3.51e-01 2.33e-01 4.38e-02 1.81e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 14 4.07e-02 1.11e-01 0.42100 -3.66e-01 -2.08e-01 1.76e-02 1.77e-01
E3 ubiquitin ligases ubiquitinate target proteins 55 5.52e-06 3.91e-05 0.42100 3.02e-01 2.94e-01 1.09e-04 1.60e-04
Cyclin E associated events during G1/S transition 82 1.71e-08 2.19e-07 0.42000 3.02e-01 2.91e-01 2.25e-06 5.10e-06
TNFR1-induced NF-kappa-B signaling pathway 30 1.41e-03 6.11e-03 0.41900 3.17e-01 2.75e-01 2.69e-03 9.15e-03
Degradation of AXIN 54 6.84e-06 4.77e-05 0.41800 3.44e-01 2.38e-01 1.23e-05 2.52e-03
Telomere Maintenance 86 7.82e-09 1.08e-07 0.41700 3.26e-01 2.60e-01 1.65e-07 3.08e-05
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 54 4.64e-06 3.34e-05 0.41500 3.79e-01 1.69e-01 1.48e-06 3.14e-02
Translation initiation complex formation 53 5.90e-06 4.16e-05 0.41400 3.79e-01 1.68e-01 1.83e-06 3.45e-02
Signaling by NOTCH4 80 3.60e-08 4.14e-07 0.41400 3.29e-01 2.51e-01 3.47e-07 1.06e-04
Cyclin A:Cdk2-associated events at S phase entry 84 1.92e-08 2.43e-07 0.41300 2.98e-01 2.86e-01 2.36e-06 5.65e-06
Mitochondrial translation termination 87 1.06e-08 1.43e-07 0.41300 2.89e-01 2.95e-01 3.17e-06 1.96e-06
DNA Double Strand Break Response 56 7.04e-06 4.86e-05 0.41200 3.22e-01 2.57e-01 3.01e-05 8.89e-04
Sensory Perception 567 1.04e-52 1.69e-49 0.41200 -2.25e-01 -3.45e-01 4.99e-20 4.92e-45
G2/M Checkpoints 144 7.86e-14 2.67e-12 0.41200 2.98e-01 2.84e-01 6.66e-10 3.87e-09
Protein lipoylation 10 1.20e-01 2.47e-01 0.41000 3.37e-01 2.33e-01 6.49e-02 2.02e-01
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 60 3.83e-06 2.82e-05 0.41000 2.89e-01 2.90e-01 1.07e-04 1.01e-04
Nuclear import of Rev protein 34 2.97e-04 1.54e-03 0.40900 8.97e-02 3.99e-01 3.66e-01 5.59e-05
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 3.48e-02 9.65e-02 0.40900 2.46e-01 3.27e-01 8.82e-02 2.36e-02
Pausing and recovery of Tat-mediated HIV elongation 31 1.36e-03 5.92e-03 0.40800 3.48e-01 2.13e-01 7.87e-04 3.98e-02
Tat-mediated HIV elongation arrest and recovery 31 1.36e-03 5.92e-03 0.40800 3.48e-01 2.13e-01 7.87e-04 3.98e-02
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 10 1.03e-01 2.23e-01 0.40800 3.86e-01 1.32e-01 3.46e-02 4.69e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 55 1.13e-05 7.45e-05 0.40700 3.25e-01 2.45e-01 3.11e-05 1.68e-03
Cellular response to hypoxia 73 2.94e-07 2.59e-06 0.40700 3.17e-01 2.55e-01 2.90e-06 1.63e-04
Regulation of TNFR1 signaling 46 8.05e-05 4.52e-04 0.40700 2.88e-01 2.87e-01 7.17e-04 7.68e-04
Golgi Cisternae Pericentriolar Stack Reorganization 14 4.67e-02 1.23e-01 0.40600 1.62e-01 3.72e-01 2.94e-01 1.59e-02
Mitochondrial translation 93 5.86e-09 8.69e-08 0.40600 2.87e-01 2.87e-01 1.71e-06 1.74e-06
Termination of O-glycan biosynthesis 25 5.71e-03 2.08e-02 0.40500 -3.28e-01 -2.38e-01 4.51e-03 3.92e-02
CYP2E1 reactions 11 9.87e-02 2.16e-01 0.40400 -3.53e-01 -1.96e-01 4.25e-02 2.61e-01
p75NTR signals via NF-kB 15 4.12e-02 1.12e-01 0.40300 3.61e-01 1.80e-01 1.55e-02 2.27e-01
Infection with Mycobacterium tuberculosis 25 6.20e-03 2.22e-02 0.40300 3.22e-01 2.41e-01 5.25e-03 3.69e-02
Response of Mtb to phagocytosis 22 1.13e-02 3.72e-02 0.40200 3.29e-01 2.30e-01 7.46e-03 6.14e-02
Protein ubiquitination 73 4.40e-07 3.81e-06 0.40200 2.68e-01 2.99e-01 7.31e-05 9.77e-06
Mitochondrial translation initiation 87 2.85e-08 3.47e-07 0.40200 2.85e-01 2.83e-01 4.46e-06 4.89e-06
Mitochondrial translation elongation 87 2.91e-08 3.51e-07 0.40100 2.82e-01 2.85e-01 5.31e-06 4.20e-06
Defective Intrinsic Pathway for Apoptosis 25 6.53e-03 2.32e-02 0.40100 3.20e-01 2.41e-01 5.59e-03 3.71e-02
p75NTR recruits signalling complexes 12 8.31e-02 1.91e-01 0.40000 3.52e-01 1.91e-01 3.49e-02 2.51e-01
Asymmetric localization of PCP proteins 63 3.24e-06 2.46e-05 0.40000 3.20e-01 2.40e-01 1.10e-05 9.79e-04
Complex I biogenesis 58 1.05e-05 6.97e-05 0.39900 2.66e-01 2.98e-01 4.66e-04 8.74e-05
Polo-like kinase mediated events 16 2.75e-02 7.91e-02 0.39800 9.57e-02 3.87e-01 5.08e-01 7.40e-03
Erythrocytes take up carbon dioxide and release oxygen 12 9.38e-02 2.09e-01 0.39700 -2.46e-01 -3.12e-01 1.41e-01 6.13e-02
O2/CO2 exchange in erythrocytes 12 9.38e-02 2.09e-01 0.39700 -2.46e-01 -3.12e-01 1.41e-01 6.13e-02
Nitric oxide stimulates guanylate cyclase 21 6.50e-03 2.31e-02 0.39600 -2.36e-02 -3.96e-01 8.51e-01 1.70e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript 70 1.11e-06 8.98e-06 0.39600 2.40e-01 3.14e-01 5.04e-04 5.34e-06
DNA Damage Recognition in GG-NER 36 9.22e-04 4.36e-03 0.39500 2.69e-01 2.90e-01 5.16e-03 2.64e-03
Unwinding of DNA 12 9.66e-02 2.13e-01 0.39500 2.56e-01 3.01e-01 1.25e-01 7.06e-02
Nonhomologous End-Joining (NHEJ) 46 1.29e-04 7.10e-04 0.39500 3.08e-01 2.48e-01 3.05e-04 3.63e-03
Mitochondrial protein import 58 9.93e-06 6.67e-05 0.39500 2.07e-01 3.36e-01 6.33e-03 9.52e-06
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 2.77e-02 7.93e-02 0.39400 1.36e-01 3.70e-01 3.32e-01 8.20e-03
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 2.77e-02 7.93e-02 0.39400 1.36e-01 3.70e-01 3.32e-01 8.20e-03
Activation of NF-kappaB in B cells 65 3.40e-06 2.55e-05 0.39400 3.08e-01 2.46e-01 1.75e-05 6.02e-04
ATF6 (ATF6-alpha) activates chaperone genes 10 1.42e-01 2.82e-01 0.39400 2.29e-01 3.20e-01 2.10e-01 7.95e-02
Hedgehog ligand biogenesis 64 4.28e-06 3.11e-05 0.39400 3.06e-01 2.47e-01 2.24e-05 6.27e-04
mRNA 3’-end processing 54 3.43e-05 2.08e-04 0.39200 2.72e-01 2.82e-01 5.50e-04 3.33e-04
HIV elongation arrest and recovery 33 1.40e-03 6.07e-03 0.39100 3.48e-01 1.79e-01 5.45e-04 7.44e-02
Pausing and recovery of HIV elongation 33 1.40e-03 6.07e-03 0.39100 3.48e-01 1.79e-01 5.45e-04 7.44e-02
G1/S Transition 127 3.29e-11 7.78e-10 0.39100 2.49e-01 3.01e-01 1.22e-06 4.39e-09
Metalloprotease DUBs 27 5.95e-03 2.15e-02 0.39100 2.72e-01 2.81e-01 1.43e-02 1.16e-02
Cristae formation 29 3.22e-03 1.24e-02 0.39000 1.79e-01 3.47e-01 9.55e-02 1.23e-03
Receptor Mediated Mitophagy 10 9.66e-02 2.13e-01 0.39000 1.77e-02 3.90e-01 9.23e-01 3.29e-02
Synthesis of DNA 119 2.08e-10 4.23e-09 0.38900 2.57e-01 2.92e-01 1.29e-06 3.75e-08
UCH proteinases 93 1.88e-08 2.40e-07 0.38900 3.26e-01 2.12e-01 5.56e-08 4.08e-04
Formation of the beta-catenin:TCF transactivating complex 55 2.01e-05 1.27e-04 0.38900 3.46e-01 1.76e-01 8.83e-06 2.36e-02
Base Excision Repair 68 2.81e-06 2.14e-05 0.38800 2.45e-01 3.02e-01 4.81e-04 1.70e-05
Activation of HOX genes during differentiation 83 1.93e-07 1.80e-06 0.38800 2.61e-01 2.87e-01 3.93e-05 6.37e-06
Activation of anterior HOX genes in hindbrain development during early embryogenesis 83 1.93e-07 1.80e-06 0.38800 2.61e-01 2.87e-01 3.93e-05 6.37e-06
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 8.04e-04 3.87e-03 0.38700 1.33e-01 3.64e-01 1.74e-01 1.94e-04
NEP/NS2 Interacts with the Cellular Export Machinery 32 9.71e-04 4.55e-03 0.38700 7.14e-02 3.80e-01 4.84e-01 1.96e-04
Sphingolipid catabolism 12 9.81e-02 2.15e-01 0.38700 -1.85e-01 -3.40e-01 2.67e-01 4.17e-02
Translation 278 4.85e-23 6.08e-21 0.38600 3.03e-01 2.40e-01 3.57e-18 5.26e-12
Processing of DNA double-strand break ends 75 9.31e-07 7.67e-06 0.38600 2.92e-01 2.53e-01 1.22e-05 1.56e-04
mRNA Splicing 200 9.69e-17 5.45e-15 0.38600 2.97e-01 2.46e-01 4.02e-13 2.04e-09
Regulation of endogenous retroelements 103 4.71e-09 7.04e-08 0.38500 2.20e-01 3.15e-01 1.10e-04 3.16e-08
Folding of actin by CCT/TriC 10 1.23e-01 2.52e-01 0.38400 3.74e-01 8.98e-02 4.07e-02 6.23e-01
Metabolism of amine-derived hormones 17 4.33e-02 1.17e-01 0.38400 -3.02e-01 -2.37e-01 3.10e-02 9.01e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 23 1.46e-02 4.64e-02 0.38200 3.12e-01 2.21e-01 9.69e-03 6.62e-02
Export of Viral Ribonucleoproteins from Nucleus 33 1.16e-03 5.21e-03 0.38200 9.69e-02 3.69e-01 3.36e-01 2.41e-04
Diseases associated with glycosylation precursor biosynthesis 15 5.78e-02 1.46e-01 0.38100 1.70e-01 3.41e-01 2.55e-01 2.20e-02
mRNA Splicing - Minor Pathway 52 5.80e-05 3.36e-04 0.38100 3.35e-01 1.83e-01 2.99e-05 2.27e-02
Processing of Capped Intron-Containing Pre-mRNA 266 2.34e-21 2.38e-19 0.38100 2.66e-01 2.73e-01 7.64e-14 1.82e-14
Interactions of Rev with host cellular proteins 37 4.39e-04 2.24e-03 0.38100 7.48e-02 3.73e-01 4.31e-01 8.42e-05
tRNA processing in the nucleus 58 2.35e-05 1.45e-04 0.38100 2.07e-01 3.20e-01 6.45e-03 2.53e-05
Regulation of RAS by GAPs 66 7.11e-06 4.89e-05 0.38000 2.91e-01 2.44e-01 4.26e-05 6.07e-04
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 14 4.86e-02 1.28e-01 0.38000 3.92e-02 3.78e-01 8.00e-01 1.44e-02
Transport of Mature Transcript to Cytoplasm 79 6.26e-07 5.29e-06 0.37900 2.15e-01 3.12e-01 9.77e-04 1.60e-06
TNF signaling 54 6.75e-05 3.88e-04 0.37900 2.59e-01 2.76e-01 9.91e-04 4.46e-04
MET activates PTK2 signaling 30 4.77e-03 1.76e-02 0.37800 -2.45e-01 -2.88e-01 2.03e-02 6.26e-03
IKK complex recruitment mediated by RIP1 22 1.63e-02 5.09e-02 0.37800 1.68e-01 3.39e-01 1.72e-01 5.94e-03
Anchoring fibril formation 13 3.63e-02 9.98e-02 0.37800 1.35e-01 -3.53e-01 3.99e-01 2.74e-02
Collagen chain trimerization 42 2.93e-04 1.52e-03 0.37800 -1.29e-01 -3.55e-01 1.49e-01 6.78e-05
Telomere C-strand synthesis initiation 12 1.08e-01 2.32e-01 0.37600 1.63e-01 3.39e-01 3.28e-01 4.21e-02
Pyrimidine salvage 10 7.65e-02 1.80e-01 0.37600 -1.63e-01 3.39e-01 3.73e-01 6.36e-02
Pre-NOTCH Transcription and Translation 67 8.07e-06 5.48e-05 0.37600 2.49e-01 2.81e-01 4.17e-04 7.01e-05
Mitotic G1 phase and G1/S transition 145 8.51e-12 2.24e-10 0.37500 2.25e-01 3.00e-01 2.78e-06 4.37e-10
TNFR2 non-canonical NF-kB pathway 95 5.72e-08 6.18e-07 0.37500 2.95e-01 2.32e-01 6.62e-07 9.47e-05
HATs acetylate histones 98 3.63e-08 4.14e-07 0.37500 2.89e-01 2.40e-01 7.93e-07 4.16e-05
IRAK1 recruits IKK complex 12 1.21e-01 2.48e-01 0.37500 2.27e-01 2.98e-01 1.74e-01 7.34e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 12 1.21e-01 2.48e-01 0.37500 2.27e-01 2.98e-01 1.74e-01 7.34e-02
G1/S-Specific Transcription 28 6.06e-03 2.19e-02 0.37400 1.67e-01 3.34e-01 1.27e-01 2.19e-03
mRNA Splicing - Major Pathway 190 6.04e-15 2.66e-13 0.37300 2.86e-01 2.40e-01 1.05e-11 1.22e-08
Calnexin/calreticulin cycle 26 8.43e-03 2.92e-02 0.37300 1.52e-01 3.40e-01 1.80e-01 2.68e-03
Methylation 14 5.67e-02 1.44e-01 0.37200 3.69e-01 5.13e-02 1.69e-02 7.40e-01
Budding and maturation of HIV virion 28 3.93e-03 1.47e-02 0.37200 8.05e-02 3.63e-01 4.61e-01 8.74e-04
ATF4 activates genes in response to endoplasmic reticulum stress 27 3.19e-03 1.23e-02 0.37200 3.71e-01 1.38e-02 8.36e-04 9.01e-01
rRNA modification in the nucleus and cytosol 57 5.39e-05 3.15e-04 0.37200 2.30e-01 2.92e-01 2.69e-03 1.36e-04
Processing and activation of SUMO 10 1.39e-01 2.78e-01 0.37000 7.16e-02 3.63e-01 6.95e-01 4.71e-02
Formation of paraxial mesoderm 67 1.13e-05 7.45e-05 0.36900 2.89e-01 2.30e-01 4.32e-05 1.14e-03
SUMOylation of SUMOylation proteins 35 1.35e-03 5.91e-03 0.36900 1.05e-01 3.54e-01 2.81e-01 2.94e-04
Translesion Synthesis by POLH 18 4.53e-02 1.20e-01 0.36900 2.07e-01 3.05e-01 1.28e-01 2.50e-02
RHO GTPases activate KTN1 11 6.31e-02 1.55e-01 0.36900 -1.84e-01 3.19e-01 2.90e-01 6.67e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 4.36e-02 1.17e-01 0.36900 1.88e-01 3.17e-01 1.67e-01 1.99e-02
NS1 Mediated Effects on Host Pathways 41 5.10e-04 2.57e-03 0.36800 1.21e-01 3.48e-01 1.79e-01 1.16e-04
Reactions specific to the complex N-glycan synthesis pathway 10 1.86e-01 3.46e-01 0.36800 -2.62e-01 -2.59e-01 1.52e-01 1.56e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 8.56e-03 2.96e-02 0.36700 2.10e-01 3.01e-01 5.40e-02 5.83e-03
Transport of Ribonucleoproteins into the Host Nucleus 32 2.05e-03 8.39e-03 0.36600 6.99e-02 3.59e-01 4.94e-01 4.35e-04
Nuclear events mediated by NFE2L2 94 1.62e-07 1.55e-06 0.36600 2.38e-01 2.78e-01 6.78e-05 3.09e-06
NRIF signals cell death from the nucleus 16 6.18e-02 1.53e-01 0.36600 3.25e-01 1.68e-01 2.45e-02 2.44e-01
Cellular response to starvation 146 2.35e-11 5.89e-10 0.36600 2.98e-01 2.11e-01 4.71e-10 1.05e-05
Constitutive Signaling by Overexpressed ERBB2 11 1.07e-01 2.32e-01 0.36500 2.66e-02 3.65e-01 8.79e-01 3.63e-02
Bicarbonate transporters 10 1.72e-01 3.26e-01 0.36500 -1.53e-01 -3.32e-01 4.02e-01 6.91e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 88 3.17e-07 2.78e-06 0.36500 3.13e-01 1.88e-01 3.94e-07 2.24e-03
ER Quality Control Compartment (ERQC) 21 2.74e-02 7.89e-02 0.36500 1.81e-01 3.17e-01 1.51e-01 1.19e-02
ER-Phagosome pathway 88 5.73e-07 4.90e-06 0.36300 2.66e-01 2.47e-01 1.59e-05 6.19e-05
Response of EIF2AK1 (HRI) to heme deficiency 14 1.01e-01 2.20e-01 0.36300 2.52e-01 2.62e-01 1.03e-01 9.02e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 7.07e-02 1.69e-01 0.36300 2.94e-01 2.13e-01 4.18e-02 1.40e-01
RNA Polymerase III Transcription Initiation 36 2.34e-03 9.42e-03 0.36200 1.85e-01 3.12e-01 5.50e-02 1.20e-03
Postmitotic nuclear pore complex (NPC) reformation 27 1.01e-02 3.42e-02 0.36200 1.67e-01 3.21e-01 1.33e-01 3.86e-03
STING mediated induction of host immune responses 16 7.10e-02 1.70e-01 0.36100 3.01e-01 2.01e-01 3.74e-02 1.65e-01
Rev-mediated nuclear export of HIV RNA 35 1.22e-03 5.44e-03 0.36100 5.35e-02 3.57e-01 5.84e-01 2.55e-04
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.08e-02 3.59e-02 0.36000 2.31e-01 2.76e-01 3.43e-02 1.13e-02
Maturation of hRSV A proteins 13 1.18e-01 2.44e-01 0.36000 1.97e-01 3.02e-01 2.19e-01 5.96e-02
SUMOylation of immune response proteins 11 1.68e-01 3.21e-01 0.36000 2.85e-01 2.19e-01 1.02e-01 2.08e-01
Vpr-mediated nuclear import of PICs 34 1.15e-03 5.21e-03 0.35900 1.26e-02 3.59e-01 8.99e-01 2.91e-04
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.22e-01 2.50e-01 0.35800 1.17e-01 3.39e-01 4.84e-01 4.22e-02
Aerobic respiration and respiratory electron transport 236 6.53e-17 3.81e-15 0.35800 2.33e-01 2.71e-01 6.85e-10 6.79e-13
PERK regulates gene expression 31 2.68e-03 1.06e-02 0.35700 3.55e-01 3.74e-02 6.20e-04 7.19e-01
RNA Polymerase II Transcription Termination 63 4.84e-05 2.86e-04 0.35700 2.46e-01 2.59e-01 7.42e-04 3.85e-04
Cyclin D associated events in G1 46 6.67e-04 3.29e-03 0.35700 2.20e-01 2.81e-01 9.91e-03 9.78e-04
G1 Phase 46 6.67e-04 3.29e-03 0.35700 2.20e-01 2.81e-01 9.91e-03 9.78e-04
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 1.41e-02 4.51e-02 0.35600 2.35e-01 2.68e-01 3.44e-02 1.61e-02
Nuclear Pore Complex (NPC) Disassembly 36 9.83e-04 4.59e-03 0.35500 2.25e-02 3.55e-01 8.15e-01 2.31e-04
Interactions of Vpr with host cellular proteins 35 1.26e-03 5.62e-03 0.35400 2.62e-02 3.54e-01 7.89e-01 2.95e-04
Beta defensins 28 1.44e-03 6.21e-03 0.35400 2.95e-01 -1.95e-01 6.84e-03 7.36e-02
RUNX3 regulates p14-ARF 10 1.71e-01 3.24e-01 0.35400 8.75e-02 3.43e-01 6.32e-01 6.03e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 43 4.29e-04 2.20e-03 0.35300 6.72e-02 3.47e-01 4.46e-01 8.23e-05
Fatty acids 15 4.13e-02 1.12e-01 0.35300 3.45e-01 -7.58e-02 2.07e-02 6.11e-01
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 14 1.05e-01 2.28e-01 0.35300 1.69e-01 3.10e-01 2.72e-01 4.48e-02
Mitotic Prophase 104 6.01e-08 6.45e-07 0.35300 1.71e-01 3.08e-01 2.52e-03 5.59e-08
Metabolism of RNA 691 8.53e-46 3.48e-43 0.35200 2.66e-01 2.31e-01 9.09e-33 3.66e-25
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 17 6.98e-02 1.68e-01 0.35200 1.94e-01 2.93e-01 1.66e-01 3.63e-02
NGF-stimulated transcription 38 2.51e-03 9.94e-03 0.35100 1.84e-01 2.99e-01 4.96e-02 1.40e-03
Transport of Mature mRNA Derived from an Intronless Transcript 42 5.37e-04 2.69e-03 0.35100 6.17e-02 3.46e-01 4.89e-01 1.05e-04
Caspase activation via Death Receptors in the presence of ligand 16 8.24e-02 1.90e-01 0.35100 2.94e-01 1.92e-01 4.21e-02 1.84e-01
SUMOylation of transcription factors 20 4.65e-02 1.23e-01 0.35100 2.22e-01 2.71e-01 8.52e-02 3.58e-02
ERKs are inactivated 13 1.34e-01 2.70e-01 0.35000 2.84e-01 2.06e-01 7.65e-02 1.99e-01
Amyloid fiber formation 73 1.12e-05 7.43e-05 0.35000 2.98e-01 1.84e-01 1.07e-05 6.53e-03
Diseases associated with N-glycosylation of proteins 19 3.59e-02 9.92e-02 0.35000 7.49e-02 3.42e-01 5.72e-01 9.90e-03
TP53 Regulates Transcription of DNA Repair Genes 61 8.05e-05 4.52e-04 0.35000 2.90e-01 1.96e-01 8.95e-05 8.19e-03
Activation of the phototransduction cascade 11 1.78e-01 3.34e-01 0.34900 -3.03e-01 -1.74e-01 8.16e-02 3.18e-01
Transcriptional regulation of testis differentiation 12 1.18e-01 2.45e-01 0.34900 5.89e-02 3.44e-01 7.24e-01 3.88e-02
MyD88 deficiency (TLR2/4) 16 3.23e-02 9.06e-02 0.34900 -1.11e-01 3.31e-01 4.42e-01 2.20e-02
Keratinization 213 1.38e-15 7.01e-14 0.34900 -1.37e-01 -3.21e-01 5.50e-04 7.08e-16
Signaling by activated point mutants of FGFR1 11 1.88e-01 3.49e-01 0.34900 2.71e-01 2.19e-01 1.19e-01 2.09e-01
Formation of the anterior neural plate 10 1.27e-01 2.59e-01 0.34900 -7.14e-02 3.41e-01 6.96e-01 6.17e-02
SUMOylation of ubiquitinylation proteins 39 1.16e-03 5.22e-03 0.34900 7.64e-02 3.40e-01 4.09e-01 2.37e-04
RNA Pol II CTD phosphorylation and interaction with CE 26 1.90e-02 5.79e-02 0.34800 2.85e-01 1.99e-01 1.18e-02 7.93e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 26 1.90e-02 5.79e-02 0.34800 2.85e-01 1.99e-01 1.18e-02 7.93e-02
Regulation of RUNX2 expression and activity 71 2.30e-05 1.43e-04 0.34700 2.70e-01 2.19e-01 8.30e-05 1.44e-03
Transport of the SLBP Dependant Mature mRNA 36 2.33e-03 9.40e-03 0.34700 9.32e-02 3.34e-01 3.33e-01 5.16e-04
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 1.85e-03 7.80e-03 0.34700 2.65e-01 2.24e-01 3.01e-03 1.18e-02
HIV Transcription Elongation 42 1.85e-03 7.80e-03 0.34700 2.65e-01 2.24e-01 3.01e-03 1.18e-02
Tat-mediated elongation of the HIV-1 transcript 42 1.85e-03 7.80e-03 0.34700 2.65e-01 2.24e-01 3.01e-03 1.18e-02
TRAF3-dependent IRF activation pathway 15 9.94e-02 2.17e-01 0.34700 1.79e-01 2.97e-01 2.31e-01 4.63e-02
G2/M DNA damage checkpoint 72 2.29e-05 1.43e-04 0.34600 2.50e-01 2.39e-01 2.39e-04 4.56e-04
SUMOylation of DNA replication proteins 46 5.54e-04 2.76e-03 0.34500 1.09e-01 3.27e-01 2.02e-01 1.22e-04
Viral Messenger RNA Synthesis 44 1.29e-03 5.71e-03 0.34500 1.83e-01 2.92e-01 3.54e-02 8.03e-04
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 4.96e-03 1.82e-02 0.34500 9.28e-02 3.32e-01 3.64e-01 1.16e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 4.96e-03 1.82e-02 0.34500 9.28e-02 3.32e-01 3.64e-01 1.16e-03
Cell Cycle Checkpoints 264 1.75e-17 1.06e-15 0.34400 2.28e-01 2.58e-01 1.78e-10 4.91e-13
Ub-specific processing proteases 178 4.94e-12 1.32e-10 0.34400 2.53e-01 2.34e-01 6.03e-09 7.37e-08
Transport of the SLBP independent Mature mRNA 35 2.97e-03 1.16e-02 0.34400 8.74e-02 3.33e-01 3.71e-01 6.59e-04
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 6.13e-02 1.53e-01 0.34400 2.57e-01 2.28e-01 5.25e-02 8.49e-02
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 6.13e-02 1.53e-01 0.34400 2.57e-01 2.28e-01 5.25e-02 8.49e-02
Downstream signaling events of B Cell Receptor (BCR) 79 9.46e-06 6.41e-05 0.34300 2.63e-01 2.21e-01 5.43e-05 6.85e-04
RNA Polymerase III Chain Elongation 18 7.16e-02 1.71e-01 0.34300 2.65e-01 2.17e-01 5.16e-02 1.11e-01
HIV Transcription Initiation 43 1.97e-03 8.09e-03 0.34100 2.59e-01 2.22e-01 3.30e-03 1.17e-02
RNA Polymerase II HIV Promoter Escape 43 1.97e-03 8.09e-03 0.34100 2.59e-01 2.22e-01 3.30e-03 1.17e-02
RNA Polymerase II Promoter Escape 43 1.97e-03 8.09e-03 0.34100 2.59e-01 2.22e-01 3.30e-03 1.17e-02
RNA Polymerase II Transcription Initiation 43 1.97e-03 8.09e-03 0.34100 2.59e-01 2.22e-01 3.30e-03 1.17e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 43 1.97e-03 8.09e-03 0.34100 2.59e-01 2.22e-01 3.30e-03 1.17e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 43 1.97e-03 8.09e-03 0.34100 2.59e-01 2.22e-01 3.30e-03 1.17e-02
Lysosome Vesicle Biogenesis 33 3.13e-03 1.21e-02 0.34100 3.39e-02 3.40e-01 7.36e-01 7.36e-04
Signaling by ROBO receptors 207 5.74e-14 1.99e-12 0.34100 2.91e-01 1.78e-01 5.60e-13 9.62e-06
Hormone ligand-binding receptors 13 1.20e-01 2.47e-01 0.34100 -8.71e-02 -3.30e-01 5.87e-01 3.96e-02
ATF6 (ATF6-alpha) activates chaperones 11 2.05e-01 3.70e-01 0.33900 2.14e-01 2.64e-01 2.20e-01 1.30e-01
Hedgehog ‘on’ state 85 5.51e-06 3.91e-05 0.33900 2.52e-01 2.27e-01 5.92e-05 3.00e-04
Formation of the Early Elongation Complex 32 1.09e-02 3.62e-02 0.33700 2.42e-01 2.35e-01 1.80e-02 2.12e-02
Formation of the HIV-1 Early Elongation Complex 32 1.09e-02 3.62e-02 0.33700 2.42e-01 2.35e-01 1.80e-02 2.12e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 13 9.32e-02 2.09e-01 0.33700 -2.36e-02 3.36e-01 8.83e-01 3.61e-02
Signaling by FLT3 ITD and TKD mutants 16 9.44e-02 2.10e-01 0.33600 1.52e-01 3.00e-01 2.92e-01 3.78e-02
S Phase 159 2.52e-10 5.02e-09 0.33500 2.20e-01 2.53e-01 1.63e-06 3.84e-08
Cellular Senescence 159 1.55e-10 3.25e-09 0.33500 1.77e-01 2.84e-01 1.14e-04 6.30e-10
Transcriptional regulation by RUNX3 93 2.30e-06 1.79e-05 0.33500 2.62e-01 2.09e-01 1.27e-05 5.08e-04
Regulation of PTEN mRNA translation 25 5.81e-03 2.11e-02 0.33500 -2.93e-01 1.61e-01 1.12e-02 1.63e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 1.89e-01 3.49e-01 0.33400 2.50e-01 2.22e-01 1.34e-01 1.83e-01
HCMV Early Events 100 9.62e-07 7.89e-06 0.33400 2.13e-01 2.57e-01 2.24e-04 9.12e-06
Formation of HIV elongation complex in the absence of HIV Tat 44 2.16e-03 8.80e-03 0.33300 2.68e-01 1.99e-01 2.10e-03 2.27e-02
Oxidative Stress Induced Senescence 88 3.82e-06 2.82e-05 0.33300 1.71e-01 2.86e-01 5.62e-03 3.48e-06
Host Interactions of HIV factors 127 2.41e-08 3.00e-07 0.33300 2.05e-01 2.62e-01 6.46e-05 3.30e-07
KSRP (KHSRP) binds and destabilizes mRNA 17 3.61e-02 9.95e-02 0.33300 3.14e-01 -1.08e-01 2.48e-02 4.40e-01
RNA polymerase II transcribes snRNA genes 74 3.91e-05 2.35e-04 0.33200 2.13e-01 2.55e-01 1.56e-03 1.48e-04
Glucocorticoid biosynthesis 10 1.63e-01 3.13e-01 0.33100 4.57e-02 -3.28e-01 8.02e-01 7.28e-02
HCMV Infection 124 3.81e-08 4.32e-07 0.33100 1.86e-01 2.74e-01 3.47e-04 1.42e-07
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 22 4.96e-02 1.30e-01 0.33000 2.64e-01 1.98e-01 3.20e-02 1.08e-01
Neurodegenerative Diseases 22 4.96e-02 1.30e-01 0.33000 2.64e-01 1.98e-01 3.20e-02 1.08e-01
Meiotic synapsis 54 7.02e-04 3.45e-03 0.32900 2.25e-01 2.41e-01 4.25e-03 2.23e-03
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 6.99e-02 1.68e-01 0.32900 1.42e-02 3.29e-01 9.22e-01 2.29e-02
Antigen processing-Cross presentation 101 1.40e-06 1.12e-05 0.32800 2.42e-01 2.21e-01 2.57e-05 1.20e-04
Regulation of BACH1 activity 15 1.35e-01 2.71e-01 0.32700 2.12e-01 2.50e-01 1.55e-01 9.42e-02
Transcription of the HIV genome 66 1.56e-04 8.47e-04 0.32700 2.50e-01 2.11e-01 4.46e-04 3.09e-03
FCERI mediated NF-kB activation 78 3.14e-05 1.91e-04 0.32700 2.54e-01 2.05e-01 1.02e-04 1.75e-03
Activation of ATR in response to replication stress 37 7.38e-03 2.58e-02 0.32700 2.13e-01 2.48e-01 2.52e-02 9.08e-03
Signaling by CSF3 (G-CSF) 30 1.93e-02 5.85e-02 0.32500 2.17e-01 2.43e-01 3.99e-02 2.13e-02
Ketone body metabolism 10 2.70e-01 4.48e-01 0.32400 -2.45e-01 -2.13e-01 1.80e-01 2.43e-01
HIV Life Cycle 145 2.69e-09 4.30e-08 0.32400 1.49e-01 2.88e-01 1.97e-03 2.10e-09
mRNA Capping 28 2.56e-02 7.48e-02 0.32300 2.56e-01 1.98e-01 1.91e-02 7.01e-02
SARS-CoV-1 Infection 136 2.16e-08 2.71e-07 0.32300 1.97e-01 2.55e-01 7.12e-05 2.67e-07
RNA Polymerase II Pre-transcription Events 77 4.84e-05 2.86e-04 0.32300 2.41e-01 2.14e-01 2.56e-04 1.14e-03
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 59 4.98e-04 2.52e-03 0.32200 2.23e-01 2.33e-01 3.00e-03 2.00e-03
Selective autophagy 84 2.01e-05 1.27e-04 0.32200 2.16e-01 2.39e-01 6.09e-04 1.53e-04
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 1.16e-01 2.41e-01 0.32100 1.45e-01 2.87e-01 3.16e-01 4.70e-02
VLDLR internalisation and degradation 16 1.29e-01 2.61e-01 0.32100 2.15e-01 2.38e-01 1.36e-01 9.88e-02
RHO GTPases activate PKNs 56 7.77e-04 3.75e-03 0.32100 2.42e-01 2.11e-01 1.74e-03 6.39e-03
Nucleotide salvage 21 2.64e-02 7.65e-02 0.32000 -6.01e-02 3.15e-01 6.34e-01 1.25e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 15 1.24e-01 2.54e-01 0.32000 1.12e-01 3.00e-01 4.53e-01 4.40e-02
PCP/CE pathway 91 9.53e-06 6.43e-05 0.32000 2.33e-01 2.20e-01 1.25e-04 2.83e-04
Oncogene Induced Senescence 35 1.08e-02 3.60e-02 0.32000 1.83e-01 2.63e-01 6.09e-02 7.14e-03
Heme degradation 16 8.84e-02 2.00e-01 0.32000 -4.19e-02 -3.17e-01 7.72e-01 2.81e-02
Downstream TCR signaling 93 4.08e-06 2.98e-05 0.32000 2.87e-01 1.41e-01 1.69e-06 1.92e-02
activated TAK1 mediates p38 MAPK activation 20 7.00e-02 1.68e-01 0.31900 1.45e-01 2.85e-01 2.63e-01 2.75e-02
Nucleotide biosynthesis 12 2.01e-01 3.65e-01 0.31900 1.39e-01 2.87e-01 4.03e-01 8.50e-02
Formation of apoptosome 10 1.53e-01 2.97e-01 0.31900 2.77e-01 -1.58e-01 1.29e-01 3.86e-01
Regulation of the apoptosome activity 10 1.53e-01 2.97e-01 0.31900 2.77e-01 -1.58e-01 1.29e-01 3.86e-01
Signaling by FGFR2 IIIa TM 19 7.99e-02 1.86e-01 0.31900 2.86e-01 1.41e-01 3.10e-02 2.86e-01
HIV Infection 223 6.97e-13 2.11e-11 0.31800 1.91e-01 2.54e-01 8.57e-07 6.50e-11
Degradation of beta-catenin by the destruction complex 83 3.05e-05 1.87e-04 0.31800 2.41e-01 2.07e-01 1.46e-04 1.13e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.54e-01 2.98e-01 0.31700 6.64e-02 3.10e-01 6.79e-01 5.29e-02
Elevation of cytosolic Ca2+ levels 16 4.90e-02 1.28e-01 0.31600 -2.47e-01 1.97e-01 8.69e-02 1.71e-01
ISG15 antiviral mechanism 74 8.27e-05 4.62e-04 0.31600 1.70e-01 2.67e-01 1.15e-02 7.15e-05
Regulation of PTEN stability and activity 67 2.46e-04 1.30e-03 0.31600 2.31e-01 2.16e-01 1.06e-03 2.25e-03
Processing of Intronless Pre-mRNAs 19 6.71e-02 1.63e-01 0.31600 7.17e-02 3.08e-01 5.88e-01 2.01e-02
RNA Polymerase I Transcription Termination 29 2.65e-02 7.68e-02 0.31600 2.52e-01 1.91e-01 1.90e-02 7.44e-02
Regulation of NF-kappa B signaling 17 1.14e-01 2.40e-01 0.31600 2.70e-01 1.65e-01 5.44e-02 2.39e-01
Formation of RNA Pol II elongation complex 57 8.34e-04 3.98e-03 0.31600 2.46e-01 1.99e-01 1.34e-03 9.48e-03
RNA Polymerase II Transcription Elongation 57 8.34e-04 3.98e-03 0.31600 2.46e-01 1.99e-01 1.34e-03 9.48e-03
FGFR2 alternative splicing 26 3.78e-02 1.04e-01 0.31500 2.65e-01 1.71e-01 1.95e-02 1.32e-01
Formation of TC-NER Pre-Incision Complex 49 2.30e-03 9.27e-03 0.31500 2.50e-01 1.92e-01 2.50e-03 2.01e-02
FLT3 signaling in disease 28 2.46e-02 7.19e-02 0.31400 1.17e-01 2.92e-01 2.83e-01 7.57e-03
SARS-CoV-2 modulates autophagy 11 1.76e-01 3.31e-01 0.31400 -1.71e-02 3.14e-01 9.22e-01 7.16e-02
Pre-NOTCH Expression and Processing 83 2.96e-05 1.81e-04 0.31400 1.63e-01 2.68e-01 1.04e-02 2.35e-05
ABC transporter disorders 76 7.25e-05 4.15e-04 0.31300 2.69e-01 1.61e-01 5.00e-05 1.54e-02
Transcriptional Regulation by E2F6 32 4.62e-03 1.71e-02 0.31300 -7.23e-02 3.05e-01 4.79e-01 2.83e-03
Aspartate and asparagine metabolism 11 2.53e-01 4.31e-01 0.31300 -2.65e-01 -1.67e-01 1.28e-01 3.37e-01
Interaction between L1 and Ankyrins 30 7.58e-03 2.64e-02 0.31300 4.54e-02 -3.10e-01 6.67e-01 3.30e-03
Negative regulation of FGFR1 signaling 32 2.02e-02 6.11e-02 0.31300 2.36e-01 2.05e-01 2.07e-02 4.45e-02
Late Phase of HIV Life Cycle 132 6.22e-08 6.55e-07 0.31300 1.50e-01 2.74e-01 2.86e-03 5.34e-08
Passive transport by Aquaporins 13 1.95e-01 3.57e-01 0.31200 -1.52e-01 -2.73e-01 3.44e-01 8.83e-02
Collagen biosynthesis and modifying enzymes 65 2.86e-04 1.49e-03 0.31200 -1.53e-01 -2.73e-01 3.34e-02 1.44e-04
Mitotic Metaphase and Anaphase 226 1.54e-12 4.41e-11 0.31100 1.88e-01 2.48e-01 1.12e-06 1.30e-10
Activation of the pre-replicative complex 31 2.13e-02 6.35e-02 0.31100 1.52e-01 2.71e-01 1.42e-01 9.09e-03
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 14 1.74e-01 3.29e-01 0.31000 1.46e-01 2.74e-01 3.44e-01 7.60e-02
Transcription of E2F targets under negative control by DREAM complex 19 1.01e-01 2.20e-01 0.31000 1.87e-01 2.47e-01 1.57e-01 6.21e-02
Negative regulation of FGFR3 signaling 28 3.46e-02 9.62e-02 0.31000 1.89e-01 2.46e-01 8.40e-02 2.44e-02
Mitotic Anaphase 225 2.58e-12 7.27e-11 0.30900 1.85e-01 2.47e-01 1.64e-06 1.72e-10
mRNA decay by 3’ to 5’ exoribonuclease 16 8.91e-02 2.01e-01 0.30900 3.08e-01 -9.84e-03 3.27e-02 9.46e-01
TRAF6 mediated NF-kB activation 24 5.16e-02 1.34e-01 0.30800 1.41e-01 2.74e-01 2.32e-01 2.02e-02
Eicosanoid ligand-binding receptors 14 8.21e-02 1.90e-01 0.30800 -1.92e-01 2.40e-01 2.13e-01 1.19e-01
Inactivation of CSF3 (G-CSF) signaling 25 5.13e-02 1.33e-01 0.30800 2.47e-01 1.83e-01 3.24e-02 1.13e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 110 2.58e-06 2.00e-05 0.30700 1.97e-01 2.35e-01 3.52e-04 2.02e-05
MAPK6/MAPK4 signaling 90 2.55e-05 1.57e-04 0.30600 2.46e-01 1.82e-01 5.35e-05 2.80e-03
Butyrophilin (BTN) family interactions 12 1.55e-01 3.00e-01 0.30600 3.03e-01 -4.15e-02 6.88e-02 8.03e-01
IRE1alpha activates chaperones 45 3.66e-03 1.38e-02 0.30600 1.17e-01 2.82e-01 1.73e-01 1.05e-03
Homology Directed Repair 116 1.47e-06 1.17e-05 0.30600 1.99e-01 2.32e-01 2.12e-04 1.60e-05
XBP1(S) activates chaperone genes 43 4.56e-03 1.70e-02 0.30600 1.12e-01 2.84e-01 2.02e-01 1.26e-03
Epigenetic regulation of gene expression 209 1.61e-11 4.10e-10 0.30400 1.44e-01 2.68e-01 3.19e-04 2.45e-11
Gene Silencing by RNA 104 5.97e-06 4.20e-05 0.30400 1.77e-01 2.47e-01 1.77e-03 1.39e-05
SUMOylation of chromatin organization proteins 57 2.37e-04 1.25e-03 0.30300 -1.26e-02 3.03e-01 8.69e-01 7.51e-05
Platelet Adhesion to exposed collagen 16 1.27e-01 2.58e-01 0.30300 -2.93e-01 -7.92e-02 4.26e-02 5.83e-01
Regulation of RUNX1 Expression and Activity 25 1.55e-02 4.88e-02 0.30300 -2.76e-01 1.26e-01 1.70e-02 2.74e-01
KEAP1-NFE2L2 pathway 125 6.42e-07 5.40e-06 0.30300 1.91e-01 2.35e-01 2.24e-04 5.62e-06
IRAK4 deficiency (TLR2/4) 17 6.21e-02 1.53e-01 0.30300 -1.09e-01 2.82e-01 4.36e-01 4.39e-02
SUMOylation of RNA binding proteins 47 1.76e-03 7.48e-03 0.30300 4.25e-02 3.00e-01 6.14e-01 3.79e-04
Cytosolic sensors of pathogen-associated DNA 63 7.77e-04 3.75e-03 0.30300 2.27e-01 1.99e-01 1.79e-03 6.17e-03
Xenobiotics 24 6.58e-02 1.60e-01 0.30200 -2.13e-01 -2.14e-01 7.07e-02 6.91e-02
Acetylcholine regulates insulin secretion 10 1.90e-01 3.51e-01 0.30200 -2.71e-01 1.33e-01 1.38e-01 4.67e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 23 5.21e-02 1.35e-01 0.30100 -2.93e-01 -7.07e-02 1.51e-02 5.57e-01
CLEC7A (Dectin-1) signaling 97 1.91e-05 1.22e-04 0.30100 2.16e-01 2.09e-01 2.32e-04 3.69e-04
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 4.37e-02 1.18e-01 0.30100 2.88e-01 8.86e-02 1.28e-02 4.43e-01
Formation of Incision Complex in GG-NER 40 8.63e-03 2.98e-02 0.30100 1.29e-01 2.72e-01 1.59e-01 2.93e-03
Nucleotide-like (purinergic) receptors 13 2.02e-01 3.66e-01 0.29900 -2.84e-01 -9.29e-02 7.59e-02 5.62e-01
Attenuation phase 25 5.57e-02 1.42e-01 0.29900 2.62e-01 1.45e-01 2.35e-02 2.10e-01
G0 and Early G1 27 4.41e-02 1.18e-01 0.29900 1.42e-01 2.63e-01 2.03e-01 1.80e-02
Nuclear Envelope Breakdown 52 7.46e-04 3.63e-03 0.29800 4.17e-03 2.98e-01 9.59e-01 1.97e-04
Maturation of TCA enzymes and regulation of TCA cycle 20 8.77e-02 1.99e-01 0.29800 9.66e-02 2.82e-01 4.55e-01 2.88e-02
NFE2L2 regulating tumorigenic genes 11 2.48e-01 4.26e-01 0.29800 6.65e-02 2.91e-01 7.03e-01 9.48e-02
Separation of Sister Chromatids 182 2.15e-09 3.50e-08 0.29800 2.13e-01 2.09e-01 7.47e-07 1.13e-06
Metabolism of non-coding RNA 52 1.65e-03 7.05e-03 0.29800 8.49e-02 2.86e-01 2.90e-01 3.63e-04
snRNP Assembly 52 1.65e-03 7.05e-03 0.29800 8.49e-02 2.86e-01 2.90e-01 3.63e-04
IRF3-mediated induction of type I IFN 13 2.19e-01 3.88e-01 0.29800 2.70e-01 1.26e-01 9.24e-02 4.30e-01
Alpha-protein kinase 1 signaling pathway 10 3.30e-01 5.20e-01 0.29800 2.34e-01 1.84e-01 2.00e-01 3.15e-01
Cytosolic tRNA aminoacylation 22 4.88e-02 1.28e-01 0.29700 4.01e-03 2.97e-01 9.74e-01 1.59e-02
Collagen degradation 61 1.00e-03 4.66e-03 0.29700 -1.47e-01 -2.58e-01 4.70e-02 4.92e-04
Fertilization 26 3.02e-02 8.58e-02 0.29700 -1.66e-02 -2.96e-01 8.83e-01 8.93e-03
Phospholipase C-mediated cascade: FGFR1 16 1.48e-01 2.89e-01 0.29600 2.79e-01 9.74e-02 5.30e-02 5.00e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 1.13e-01 2.39e-01 0.29600 2.92e-01 4.66e-02 3.72e-02 7.39e-01
Regulation of TP53 Activity through Phosphorylation 89 6.67e-05 3.85e-04 0.29500 2.14e-01 2.04e-01 4.89e-04 8.87e-04
Initiation of Nuclear Envelope (NE) Reformation 18 1.05e-01 2.28e-01 0.29500 6.06e-02 2.89e-01 6.56e-01 3.39e-02
Nuclear Events (kinase and transcription factor activation) 59 1.32e-03 5.82e-03 0.29500 1.39e-01 2.60e-01 6.48e-02 5.52e-04
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 1.75e-01 3.31e-01 0.29400 5.92e-02 2.88e-01 7.01e-01 6.19e-02
Free fatty acids regulate insulin secretion 10 2.71e-01 4.49e-01 0.29400 -2.93e-01 -2.42e-02 1.09e-01 8.95e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 31 2.29e-02 6.78e-02 0.29400 7.02e-02 2.85e-01 4.99e-01 6.02e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 2.19e-01 3.88e-01 0.29300 2.93e-01 -1.80e-02 9.27e-02 9.18e-01
Mitochondrial protein degradation 85 1.14e-04 6.32e-04 0.29300 1.85e-01 2.27e-01 3.18e-03 2.94e-04
MET promotes cell motility 41 1.28e-02 4.13e-02 0.29300 -2.04e-01 -2.10e-01 2.40e-02 1.98e-02
Cytochrome c-mediated apoptotic response 12 1.47e-01 2.88e-01 0.29200 2.34e-01 -1.74e-01 1.60e-01 2.97e-01
Regulated Necrosis 56 2.06e-03 8.39e-03 0.29100 1.33e-01 2.59e-01 8.49e-02 7.87e-04
Energy dependent regulation of mTOR by LKB1-AMPK 28 1.74e-02 5.42e-02 0.29100 -6.38e-02 2.84e-01 5.59e-01 9.23e-03
M Phase 367 1.61e-17 1.01e-15 0.29100 1.64e-01 2.40e-01 6.51e-08 2.69e-15
Estrogen-dependent gene expression 113 7.85e-06 5.36e-05 0.29000 1.94e-01 2.15e-01 3.57e-04 7.83e-05
Protein localization 153 1.26e-07 1.24e-06 0.29000 1.89e-01 2.20e-01 5.62e-05 2.70e-06
TBC/RABGAPs 42 6.85e-03 2.43e-02 0.28900 6.81e-02 2.81e-01 4.45e-01 1.60e-03
Chylomicron remodeling 10 2.83e-01 4.59e-01 0.28900 -2.56e-02 -2.88e-01 8.89e-01 1.15e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 15 2.05e-01 3.70e-01 0.28900 1.62e-01 2.39e-01 2.78e-01 1.09e-01
Fanconi Anemia Pathway 34 2.82e-02 8.04e-02 0.28900 1.68e-01 2.35e-01 9.05e-02 1.76e-02
tRNA processing 105 1.92e-05 1.22e-04 0.28900 1.84e-01 2.22e-01 1.12e-03 8.33e-05
RNA Polymerase III Abortive And Retractive Initiation 41 1.20e-02 3.93e-02 0.28800 1.34e-01 2.55e-01 1.38e-01 4.66e-03
RNA Polymerase III Transcription 41 1.20e-02 3.93e-02 0.28800 1.34e-01 2.55e-01 1.38e-01 4.66e-03
Purine salvage 12 2.62e-01 4.43e-01 0.28800 1.05e-01 2.68e-01 5.27e-01 1.08e-01
VEGFR2 mediated vascular permeability 26 2.54e-02 7.42e-02 0.28800 -2.80e-01 6.52e-02 1.34e-02 5.65e-01
Negative regulation of FLT3 15 2.14e-01 3.82e-01 0.28800 2.15e-01 1.91e-01 1.49e-01 2.01e-01
Negative regulation of MAPK pathway 41 1.26e-02 4.08e-02 0.28600 1.25e-01 2.57e-01 1.65e-01 4.46e-03
Unfolded Protein Response (UPR) 86 1.66e-04 8.94e-04 0.28500 2.18e-01 1.84e-01 4.71e-04 3.17e-03
FGFR2c ligand binding and activation 12 2.97e-01 4.77e-01 0.28500 1.95e-01 2.09e-01 2.43e-01 2.11e-01
FGFR1c ligand binding and activation 13 2.70e-01 4.48e-01 0.28500 2.05e-01 1.98e-01 2.00e-01 2.17e-01
Cytosolic iron-sulfur cluster assembly 12 2.86e-01 4.63e-01 0.28500 2.47e-01 1.41e-01 1.38e-01 3.97e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 1.22e-01 2.49e-01 0.28500 -2.41e-01 1.52e-01 1.19e-01 3.26e-01
tRNA Aminoacylation 40 9.02e-03 3.11e-02 0.28300 4.27e-02 2.80e-01 6.40e-01 2.19e-03
Degradation of cysteine and homocysteine 14 1.78e-01 3.34e-01 0.28300 1.01e-02 2.83e-01 9.48e-01 6.72e-02
Cell Cycle, Mitotic 508 1.40e-22 1.52e-20 0.28200 1.56e-01 2.35e-01 1.60e-09 1.01e-19
Role of LAT2/NTAL/LAB on calcium mobilization 16 1.55e-01 3.00e-01 0.28200 -2.78e-01 -4.67e-02 5.38e-02 7.46e-01
Transcriptional Regulation by VENTX 41 7.94e-03 2.76e-02 0.28200 3.60e-02 2.80e-01 6.90e-01 1.94e-03
RAF-independent MAPK1/3 activation 22 9.91e-02 2.17e-01 0.28200 2.57e-01 1.16e-01 3.69e-02 3.48e-01
Cargo concentration in the ER 32 2.05e-02 6.17e-02 0.28200 1.50e-02 2.81e-01 8.83e-01 5.88e-03
DNA Double-Strand Break Repair 146 6.18e-07 5.25e-06 0.28100 1.83e-01 2.14e-01 1.36e-04 8.38e-06
E2F mediated regulation of DNA replication 20 8.02e-02 1.86e-01 0.28100 -1.38e-02 2.81e-01 9.15e-01 2.98e-02
Mitochondrial tRNA aminoacylation 20 1.09e-01 2.32e-01 0.28100 7.09e-02 2.72e-01 5.83e-01 3.54e-02
HDL remodeling 10 3.40e-01 5.33e-01 0.28000 -8.52e-02 -2.66e-01 6.41e-01 1.45e-01
p38MAPK events 13 1.61e-01 3.09e-01 0.28000 -1.09e-01 2.58e-01 4.98e-01 1.08e-01
Regulation of IFNA/IFNB signaling 22 8.61e-02 1.96e-01 0.27900 -6.11e-02 -2.73e-01 6.20e-01 2.68e-02
Protein hydroxylation 17 1.86e-01 3.46e-01 0.27900 2.34e-01 1.51e-01 9.43e-02 2.81e-01
MET activates RAP1 and RAC1 11 2.08e-01 3.74e-01 0.27900 -2.43e-01 1.35e-01 1.62e-01 4.37e-01
Na+/Cl- dependent neurotransmitter transporters 18 7.16e-02 1.71e-01 0.27800 2.07e-01 -1.86e-01 1.29e-01 1.71e-01
Specification of the neural plate border 16 1.93e-01 3.55e-01 0.27800 1.10e-01 2.55e-01 4.47e-01 7.69e-02
Cholesterol biosynthesis 25 8.71e-02 1.98e-01 0.27800 1.57e-01 2.29e-01 1.73e-01 4.72e-02
Telomere Extension By Telomerase 22 1.15e-01 2.40e-01 0.27800 1.46e-01 2.36e-01 2.34e-01 5.53e-02
WNT5A-dependent internalization of FZD4 15 2.38e-01 4.13e-01 0.27800 1.90e-01 2.03e-01 2.03e-01 1.74e-01
Deubiquitination 247 6.76e-11 1.55e-09 0.27700 1.84e-01 2.08e-01 6.59e-07 1.82e-08
SHC-mediated cascade:FGFR3 17 1.72e-01 3.26e-01 0.27700 9.88e-02 2.59e-01 4.81e-01 6.47e-02
Negative regulators of DDX58/IFIH1 signaling 34 3.28e-02 9.16e-02 0.27500 1.10e-01 2.52e-01 2.65e-01 1.09e-02
Signaling by FGFR2 72 1.15e-03 5.21e-03 0.27500 2.11e-01 1.77e-01 1.97e-03 9.59e-03
Organic anion transporters 12 1.81e-01 3.39e-01 0.27400 1.92e-01 -1.96e-01 2.49e-01 2.40e-01
DNA Repair 298 8.46e-13 2.46e-11 0.27400 1.64e-01 2.20e-01 1.13e-06 6.46e-11
Induction of Cell-Cell Fusion 12 3.16e-01 5.03e-01 0.27300 -1.36e-01 -2.37e-01 4.13e-01 1.55e-01
Regulation of pyruvate metabolism 31 5.68e-02 1.44e-01 0.27300 1.88e-01 1.98e-01 7.05e-02 5.61e-02
Gastrulation 125 1.03e-05 6.87e-05 0.27300 1.86e-01 1.99e-01 3.28e-04 1.19e-04
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 12 3.20e-01 5.06e-01 0.27200 2.34e-01 1.39e-01 1.60e-01 4.05e-01
Diseases associated with visual transduction 11 3.65e-01 5.58e-01 0.27100 -1.76e-01 -2.06e-01 3.11e-01 2.37e-01
Diseases of the neuronal system 11 3.65e-01 5.58e-01 0.27100 -1.76e-01 -2.06e-01 3.11e-01 2.37e-01
Retinoid cycle disease events 11 3.65e-01 5.58e-01 0.27100 -1.76e-01 -2.06e-01 3.11e-01 2.37e-01
SHC-mediated cascade:FGFR1 21 1.47e-01 2.89e-01 0.27100 1.89e-01 1.95e-01 1.35e-01 1.22e-01
Formation of definitive endoderm 16 1.15e-01 2.40e-01 0.27100 -1.34e-01 2.35e-01 3.53e-01 1.03e-01
Diseases associated with the TLR signaling cascade 29 2.67e-02 7.69e-02 0.27100 -6.04e-02 2.64e-01 5.73e-01 1.39e-02
Diseases of Immune System 29 2.67e-02 7.69e-02 0.27100 -6.04e-02 2.64e-01 5.73e-01 1.39e-02
Transcriptional regulation of pluripotent stem cells 28 2.38e-02 7.05e-02 0.26900 -1.33e-01 2.34e-01 2.22e-01 3.24e-02
FOXO-mediated transcription of cell death genes 15 2.30e-01 4.04e-01 0.26900 2.52e-01 9.34e-02 9.10e-02 5.31e-01
Interleukin-1 signaling 110 5.34e-05 3.13e-04 0.26900 1.99e-01 1.80e-01 3.01e-04 1.10e-03
Downregulation of ERBB2:ERBB3 signaling 13 2.95e-01 4.74e-01 0.26800 1.21e-01 2.40e-01 4.51e-01 1.35e-01
TCR signaling 112 2.29e-05 1.43e-04 0.26700 2.48e-01 9.87e-02 5.68e-06 7.12e-02
Signaling by NOTCH3 48 1.08e-02 3.60e-02 0.26600 2.45e-01 1.05e-01 3.35e-03 2.08e-01
Nuclear Envelope (NE) Reassembly 73 1.12e-03 5.11e-03 0.26600 1.11e-01 2.42e-01 1.00e-01 3.58e-04
Activation of SMO 18 1.89e-01 3.49e-01 0.26600 1.16e-01 2.39e-01 3.96e-01 7.87e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.33e-01 2.68e-01 0.26600 2.61e-01 -4.92e-02 6.25e-02 7.25e-01
HSF1 activation 27 9.29e-02 2.09e-01 0.26500 2.10e-01 1.61e-01 5.84e-02 1.47e-01
Cell Cycle 633 1.47e-24 2.18e-22 0.26500 1.48e-01 2.20e-01 2.22e-10 2.90e-21
Laminin interactions 28 8.23e-02 1.90e-01 0.26500 -1.43e-01 -2.23e-01 1.91e-01 4.10e-02
Miscellaneous transport and binding events 24 1.10e-01 2.34e-01 0.26500 -1.15e-01 -2.38e-01 3.30e-01 4.32e-02
NOTCH2 intracellular domain regulates transcription 11 3.85e-01 5.74e-01 0.26400 1.88e-01 1.86e-01 2.80e-01 2.86e-01
FGFR2 mutant receptor activation 32 5.00e-02 1.30e-01 0.26400 2.45e-01 9.79e-02 1.63e-02 3.38e-01
TCF dependent signaling in response to WNT 192 7.11e-08 7.38e-07 0.26400 1.91e-01 1.82e-01 5.18e-06 1.34e-05
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 19 1.60e-01 3.09e-01 0.26300 7.15e-02 2.53e-01 5.90e-01 5.63e-02
Trafficking and processing of endosomal TLR 11 3.15e-01 5.02e-01 0.26200 1.37e-02 2.61e-01 9.37e-01 1.33e-01
Interleukin-20 family signaling 26 4.27e-02 1.16e-01 0.26200 8.73e-02 -2.47e-01 4.41e-01 2.94e-02
ZBP1(DAI) mediated induction of type I IFNs 20 1.82e-01 3.39e-01 0.26100 2.03e-01 1.64e-01 1.16e-01 2.03e-01
MET receptor recycling 10 2.76e-01 4.54e-01 0.26100 -1.67e-01 2.01e-01 3.62e-01 2.71e-01
Cellular responses to stress 742 3.78e-27 8.80e-25 0.26100 1.75e-01 1.93e-01 4.75e-16 2.66e-19
Hedgehog ‘off’ state 110 7.33e-05 4.17e-04 0.26000 2.26e-01 1.29e-01 4.35e-05 1.92e-02
Detoxification of Reactive Oxygen Species 34 5.79e-02 1.46e-01 0.25900 1.98e-01 1.68e-01 4.58e-02 9.05e-02
Negative regulation of FGFR4 signaling 30 8.12e-02 1.88e-01 0.25900 1.67e-01 1.98e-01 1.13e-01 6.04e-02
RORA activates gene expression 17 1.21e-01 2.48e-01 0.25900 -2.22e-01 1.34e-01 1.14e-01 3.38e-01
Signaling by NOTCH 205 4.64e-08 5.22e-07 0.25900 1.76e-01 1.89e-01 1.40e-05 2.92e-06
Processing of Capped Intronless Pre-mRNA 28 7.64e-02 1.80e-01 0.25800 7.72e-02 2.46e-01 4.80e-01 2.41e-02
Cellular responses to stimuli 756 5.83e-27 1.19e-24 0.25800 1.74e-01 1.90e-01 3.63e-16 5.76e-19
Regulation of TP53 Activity through Association with Co-factors 14 2.05e-01 3.70e-01 0.25700 -2.51e-01 5.69e-02 1.04e-01 7.12e-01
Phase 0 - rapid depolarisation 31 3.16e-02 8.92e-02 0.25700 4.90e-02 -2.52e-01 6.37e-01 1.50e-02
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 10 3.19e-01 5.06e-01 0.25700 -2.48e-01 6.66e-02 1.74e-01 7.15e-01
NOTCH3 Intracellular Domain Regulates Transcription 24 1.36e-01 2.74e-01 0.25700 2.08e-01 1.51e-01 7.74e-02 2.02e-01
Antiviral mechanism by IFN-stimulated genes 144 7.58e-06 5.20e-05 0.25700 1.64e-01 1.98e-01 6.83e-04 4.15e-05
Nephron development 13 3.15e-01 5.03e-01 0.25700 9.29e-02 2.39e-01 5.62e-01 1.35e-01
Signaling by WNT in cancer 32 1.92e-02 5.85e-02 0.25600 -1.54e-01 2.05e-01 1.32e-01 4.46e-02
NFE2L2 regulating anti-oxidant/detoxification enzymes 19 1.12e-01 2.38e-01 0.25600 -7.58e-02 2.45e-01 5.67e-01 6.45e-02
NOTCH4 Intracellular Domain Regulates Transcription 19 2.13e-01 3.82e-01 0.25600 1.77e-01 1.85e-01 1.81e-01 1.63e-01
Chemokine receptors bind chemokines 56 1.03e-03 4.76e-03 0.25500 1.96e-01 -1.64e-01 1.14e-02 3.34e-02
MTOR signalling 40 1.21e-02 3.94e-02 0.25500 -5.16e-02 2.50e-01 5.73e-01 6.21e-03
Maturation of nucleoprotein 9683610 11 2.63e-01 4.43e-01 0.25500 1.43e-01 -2.11e-01 4.13e-01 2.25e-01
Mitochondrial biogenesis 87 5.23e-04 2.63e-03 0.25400 9.32e-02 2.37e-01 1.33e-01 1.34e-04
Collagen formation 88 7.07e-04 3.46e-03 0.25400 -1.33e-01 -2.17e-01 3.11e-02 4.33e-04
Viral Infection Pathways 757 1.96e-26 3.56e-24 0.25400 1.57e-01 2.00e-01 1.74e-13 8.44e-21
BBSome-mediated cargo-targeting to cilium 23 1.55e-01 3.00e-01 0.25400 2.07e-01 1.47e-01 8.64e-02 2.22e-01
Synthesis of bile acids and bile salts 33 5.36e-02 1.38e-01 0.25300 -2.42e-01 -7.55e-02 1.62e-02 4.53e-01
Signaling by FGFR3 39 4.25e-02 1.15e-01 0.25300 1.39e-01 2.11e-01 1.33e-01 2.24e-02
Recycling of bile acids and salts 18 2.40e-01 4.16e-01 0.25300 -1.81e-01 -1.76e-01 1.83e-01 1.96e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 2.66e-01 4.44e-01 0.25300 2.42e-01 7.45e-02 1.05e-01 6.17e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 2.66e-01 4.44e-01 0.25300 2.42e-01 7.45e-02 1.05e-01 6.17e-01
TGFBR3 expression 28 6.99e-02 1.68e-01 0.25200 -2.51e-01 -2.93e-02 2.16e-02 7.88e-01
Signaling by EGFR in Cancer 25 1.26e-01 2.57e-01 0.25200 1.16e-01 2.24e-01 3.17e-01 5.22e-02
COPII-mediated vesicle transport 67 1.83e-03 7.79e-03 0.25200 3.27e-02 2.50e-01 6.44e-01 4.01e-04
FCGR activation 12 2.51e-01 4.29e-01 0.25100 1.11e-01 -2.26e-01 5.06e-01 1.76e-01
mTORC1-mediated signalling 23 1.07e-01 2.32e-01 0.25100 1.16e-02 2.51e-01 9.24e-01 3.72e-02
Peptide hormone biosynthesis 11 3.88e-01 5.76e-01 0.25100 -2.37e-01 -8.18e-02 1.73e-01 6.39e-01
The NLRP3 inflammasome 16 2.42e-01 4.18e-01 0.25100 6.09e-02 2.43e-01 6.73e-01 9.24e-02
Chaperone Mediated Autophagy 20 1.68e-01 3.20e-01 0.25000 2.44e-01 5.66e-02 5.89e-02 6.61e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 53 1.23e-02 4.00e-02 0.25000 9.84e-02 2.30e-01 2.15e-01 3.82e-03
Assembly of collagen fibrils and other multimeric structures 59 7.07e-03 2.49e-02 0.24900 -8.53e-02 -2.34e-01 2.57e-01 1.89e-03
RHOJ GTPase cycle 50 1.05e-02 3.54e-02 0.24900 -2.46e-01 -3.55e-02 2.60e-03 6.64e-01
Macroautophagy 135 2.28e-05 1.43e-04 0.24800 1.20e-01 2.17e-01 1.60e-02 1.30e-05
Acyl chain remodelling of PI 17 1.41e-01 2.80e-01 0.24800 1.46e-01 -2.01e-01 2.98e-01 1.52e-01
Autophagy 149 6.91e-06 4.80e-05 0.24800 1.11e-01 2.22e-01 1.95e-02 3.01e-06
Cellular response to chemical stress 201 2.40e-07 2.20e-06 0.24800 1.59e-01 1.90e-01 1.06e-04 3.32e-06
Signaling by NOTCH2 32 8.47e-02 1.93e-01 0.24700 2.03e-01 1.41e-01 4.66e-02 1.67e-01
Synthesis of PIPs at the late endosome membrane 10 3.17e-01 5.04e-01 0.24700 -1.99e-01 1.47e-01 2.76e-01 4.22e-01
Mitotic Spindle Checkpoint 108 2.54e-04 1.33e-03 0.24700 1.38e-01 2.05e-01 1.34e-02 2.39e-04
Mitotic G2-G2/M phases 193 5.30e-07 4.55e-06 0.24600 1.70e-01 1.79e-01 4.77e-05 1.85e-05
Assembly of active LPL and LIPC lipase complexes 18 1.28e-01 2.60e-01 0.24600 1.62e-01 -1.85e-01 2.33e-01 1.75e-01
Metabolism of cofactors 25 1.46e-01 2.88e-01 0.24600 1.32e-01 2.07e-01 2.53e-01 7.26e-02
Signal amplification 33 2.42e-02 7.11e-02 0.24600 -1.36e-01 2.05e-01 1.77e-01 4.16e-02
Purine catabolism 17 2.51e-01 4.29e-01 0.24600 2.29e-01 9.01e-02 1.02e-01 5.20e-01
Ovarian tumor domain proteases 36 4.51e-02 1.20e-01 0.24600 5.32e-02 2.40e-01 5.81e-01 1.28e-02
Negative regulation of FGFR2 signaling 33 8.47e-02 1.93e-01 0.24600 1.68e-01 1.79e-01 9.54e-02 7.46e-02
Thromboxane signalling through TP receptor 24 7.86e-02 1.84e-01 0.24500 -7.83e-02 2.32e-01 5.07e-01 4.87e-02
RUNX3 regulates NOTCH signaling 13 3.70e-01 5.60e-01 0.24500 2.07e-01 1.32e-01 1.97e-01 4.10e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 35 6.76e-02 1.64e-01 0.24500 1.24e-01 2.11e-01 2.04e-01 3.04e-02
FRS-mediated FGFR1 signaling 23 1.79e-01 3.35e-01 0.24500 1.89e-01 1.56e-01 1.17e-01 1.94e-01
Pyruvate metabolism 46 3.27e-02 9.14e-02 0.24500 1.63e-01 1.83e-01 5.65e-02 3.18e-02
G2/M Transition 191 8.24e-07 6.82e-06 0.24400 1.67e-01 1.78e-01 6.83e-05 2.27e-05
Translesion synthesis by POLI 17 2.79e-01 4.54e-01 0.24400 2.03e-01 1.35e-01 1.48e-01 3.34e-01
Meiosis 82 2.37e-03 9.49e-03 0.24400 1.58e-01 1.86e-01 1.35e-02 3.65e-03
Prefoldin mediated transfer of substrate to CCT/TriC 26 1.12e-01 2.38e-01 0.24300 2.37e-01 5.58e-02 3.66e-02 6.22e-01
HSF1-dependent transactivation 35 6.49e-02 1.59e-01 0.24300 2.21e-01 1.01e-01 2.34e-02 3.02e-01
O-linked glycosylation of mucins 62 5.66e-03 2.06e-02 0.24300 -2.36e-01 -5.56e-02 1.30e-03 4.49e-01
Signaling by FGFR4 40 5.25e-02 1.35e-01 0.24200 1.44e-01 1.95e-01 1.16e-01 3.28e-02
FGFR1 ligand binding and activation 17 2.66e-01 4.45e-01 0.24200 2.22e-01 9.57e-02 1.13e-01 4.94e-01
Global Genome Nucleotide Excision Repair (GG-NER) 81 2.48e-03 9.85e-03 0.24200 1.31e-01 2.03e-01 4.19e-02 1.55e-03
RHOBTB1 GTPase cycle 22 1.96e-01 3.59e-01 0.24100 1.32e-01 2.02e-01 2.84e-01 1.00e-01
Zygotic genome activation (ZGA) 13 3.12e-01 4.98e-01 0.24100 -9.27e-03 -2.41e-01 9.54e-01 1.32e-01
Activated NTRK2 signals through FRS2 and FRS3 11 4.43e-01 6.25e-01 0.24100 1.28e-01 2.04e-01 4.62e-01 2.41e-01
TAK1-dependent IKK and NF-kappa-B activation 41 5.18e-02 1.34e-01 0.24000 1.50e-01 1.88e-01 9.71e-02 3.71e-02
Biosynthesis of specialized proresolving mediators (SPMs) 19 1.27e-01 2.58e-01 0.24000 -1.51e-01 1.87e-01 2.54e-01 1.59e-01
Phospholipase C-mediated cascade; FGFR3 12 4.23e-01 6.08e-01 0.24000 1.83e-01 1.56e-01 2.73e-01 3.50e-01
NOD1/2 Signaling Pathway 33 7.04e-02 1.69e-01 0.24000 6.49e-02 2.31e-01 5.19e-01 2.16e-02
Regulation of HSF1-mediated heat shock response 81 2.89e-03 1.13e-02 0.24000 1.38e-01 1.96e-01 3.20e-02 2.29e-03
YAP1- and WWTR1 (TAZ)-stimulated gene expression 14 2.76e-01 4.53e-01 0.24000 2.39e-01 -1.33e-02 1.21e-01 9.32e-01
Defensins 36 2.25e-02 6.67e-02 0.24000 2.10e-01 -1.15e-01 2.89e-02 2.34e-01
RHO GTPases Activate WASPs and WAVEs 34 8.02e-02 1.86e-01 0.23900 2.11e-01 1.13e-01 3.31e-02 2.56e-01
Cell recruitment (pro-inflammatory response) 26 1.15e-01 2.40e-01 0.23900 4.08e-02 2.35e-01 7.19e-01 3.77e-02
Purinergic signaling in leishmaniasis infection 26 1.15e-01 2.40e-01 0.23900 4.08e-02 2.35e-01 7.19e-01 3.77e-02
Cellular response to heat stress 98 9.28e-04 4.37e-03 0.23900 1.43e-01 1.91e-01 1.46e-02 1.07e-03
Intrinsic Pathway of Fibrin Clot Formation 21 2.26e-01 3.98e-01 0.23800 -1.53e-01 -1.83e-01 2.26e-01 1.47e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 4.05e-01 5.93e-01 0.23800 4.44e-02 2.34e-01 7.99e-01 1.79e-01
Recognition of DNA damage by PCNA-containing replication complex 29 1.18e-01 2.45e-01 0.23800 1.11e-01 2.11e-01 3.01e-01 4.96e-02
Regulation of gene expression by Hypoxia-inducible Factor 10 4.67e-01 6.49e-01 0.23800 8.64e-02 2.22e-01 6.36e-01 2.25e-01
Neutrophil degranulation 459 3.55e-18 2.51e-16 0.23800 -3.64e-03 2.38e-01 8.94e-01 2.32e-18
HDR through MMEJ (alt-NHEJ) 12 3.98e-01 5.86e-01 0.23800 8.17e-02 2.23e-01 6.24e-01 1.80e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 4.90e-01 6.67e-01 0.23800 1.37e-01 1.94e-01 4.53e-01 2.87e-01
Toll Like Receptor 3 (TLR3) Cascade 100 7.26e-04 3.54e-03 0.23700 1.12e-01 2.08e-01 5.28e-02 3.15e-04
Regulation of commissural axon pathfinding by SLIT and ROBO 10 4.78e-01 6.60e-01 0.23600 -9.76e-02 -2.15e-01 5.93e-01 2.39e-01
Diseases associated with O-glycosylation of proteins 68 9.13e-03 3.14e-02 0.23600 -1.62e-01 -1.71e-01 2.05e-02 1.46e-02
Dual Incision in GG-NER 39 5.33e-02 1.37e-01 0.23500 7.65e-02 2.22e-01 4.08e-01 1.65e-02
TP53 Regulates Metabolic Genes 80 2.64e-03 1.04e-02 0.23400 8.15e-02 2.20e-01 2.08e-01 6.78e-04
Nucleotide Excision Repair 105 8.48e-04 4.02e-03 0.23300 1.64e-01 1.66e-01 3.74e-03 3.23e-03
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 4.81e-01 6.60e-01 0.23300 8.61e-02 2.17e-01 6.37e-01 2.35e-01
Apoptotic factor-mediated response 18 2.58e-01 4.37e-01 0.23300 2.23e-01 6.66e-02 1.01e-01 6.24e-01
Cyclin A/B1/B2 associated events during G2/M transition 24 1.85e-01 3.44e-01 0.23300 1.08e-01 2.06e-01 3.62e-01 8.03e-02
FRS-mediated FGFR3 signaling 19 2.64e-01 4.43e-01 0.23200 1.08e-01 2.06e-01 4.13e-01 1.21e-01
FGFR1 mutant receptor activation 31 1.09e-01 2.33e-01 0.23200 9.41e-02 2.12e-01 3.64e-01 4.08e-02
Killing mechanisms 11 4.79e-01 6.60e-01 0.23200 1.72e-01 1.56e-01 3.23e-01 3.71e-01
WNT5:FZD7-mediated leishmania damping 11 4.79e-01 6.60e-01 0.23200 1.72e-01 1.56e-01 3.23e-01 3.71e-01
Generation of second messenger molecules 29 6.14e-02 1.53e-01 0.23100 9.01e-02 -2.13e-01 4.01e-01 4.70e-02
RIP-mediated NFkB activation via ZBP1 16 3.45e-01 5.38e-01 0.23100 1.55e-01 1.72e-01 2.84e-01 2.34e-01
HDMs demethylate histones 18 2.82e-01 4.57e-01 0.23100 9.69e-02 2.10e-01 4.76e-01 1.23e-01
Transcriptional regulation by RUNX2 116 4.76e-04 2.42e-03 0.23100 1.66e-01 1.60e-01 1.99e-03 2.84e-03
FGFR3 mutant receptor activation 11 4.83e-01 6.60e-01 0.23100 1.65e-01 1.61e-01 3.43e-01 3.55e-01
Signaling by activated point mutants of FGFR3 11 4.83e-01 6.60e-01 0.23100 1.65e-01 1.61e-01 3.43e-01 3.55e-01
Neddylation 233 2.22e-07 2.05e-06 0.23100 1.48e-01 1.77e-01 9.88e-05 3.23e-06
ALK mutants bind TKIs 12 3.46e-01 5.38e-01 0.23100 -2.28e-01 3.54e-02 1.72e-01 8.32e-01
Plasma lipoprotein remodeling 33 6.72e-02 1.63e-01 0.23100 -9.34e-03 -2.30e-01 9.26e-01 2.20e-02
Branched-chain amino acid catabolism 20 1.93e-01 3.55e-01 0.23100 6.01e-03 2.30e-01 9.63e-01 7.44e-02
DNA Damage Bypass 46 3.63e-02 9.98e-02 0.23000 7.56e-02 2.17e-01 3.75e-01 1.08e-02
Signaling by BMP 30 8.99e-02 2.03e-01 0.23000 -1.63e-02 -2.29e-01 8.77e-01 2.97e-02
Regulation of PTEN gene transcription 59 7.02e-03 2.48e-02 0.23000 -9.88e-03 2.30e-01 8.96e-01 2.28e-03
Non-integrin membrane-ECM interactions 55 2.64e-02 7.65e-02 0.23000 -1.38e-01 -1.84e-01 7.62e-02 1.85e-02
Endosomal/Vacuolar pathway 12 3.98e-01 5.86e-01 0.23000 2.26e-01 4.01e-02 1.75e-01 8.10e-01
Interleukin-10 signaling 43 5.61e-02 1.43e-01 0.22900 1.94e-01 1.22e-01 2.74e-02 1.66e-01
Tryptophan catabolism 14 3.59e-01 5.53e-01 0.22900 -2.20e-01 -6.39e-02 1.54e-01 6.79e-01
Impaired BRCA2 binding to PALB2 24 2.02e-01 3.65e-01 0.22900 1.94e-01 1.21e-01 9.99e-02 3.03e-01
ABC-family proteins mediated transport 99 1.45e-03 6.25e-03 0.22900 1.89e-01 1.28e-01 1.12e-03 2.72e-02
RHOV GTPase cycle 36 6.08e-02 1.52e-01 0.22900 -2.27e-01 -2.86e-02 1.84e-02 7.67e-01
Transcriptional Regulation by TP53 348 1.33e-10 2.82e-09 0.22900 1.25e-01 1.91e-01 5.88e-05 8.74e-10
ERBB2 Activates PTK6 Signaling 13 2.82e-01 4.58e-01 0.22700 1.43e-01 -1.77e-01 3.72e-01 2.70e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 2.36e-01 4.11e-01 0.22700 1.92e-01 1.20e-01 1.18e-01 3.29e-01
Thrombin signalling through proteinase activated receptors (PARs) 32 6.06e-02 1.52e-01 0.22700 -4.94e-02 2.21e-01 6.28e-01 3.02e-02
Paracetamol ADME 27 1.61e-01 3.09e-01 0.22700 -2.05e-01 -9.61e-02 6.48e-02 3.87e-01
Bile acid and bile salt metabolism 44 5.97e-02 1.50e-01 0.22600 -1.80e-01 -1.36e-01 3.83e-02 1.18e-01
Translesion synthesis by REV1 16 3.62e-01 5.56e-01 0.22600 1.61e-01 1.59e-01 2.64e-01 2.72e-01
Glutathione conjugation 36 9.79e-02 2.15e-01 0.22600 1.26e-01 1.87e-01 1.90e-01 5.16e-02
Cell-extracellular matrix interactions 16 2.97e-01 4.77e-01 0.22600 2.24e-01 2.84e-02 1.21e-01 8.44e-01
Interleukin-2 signaling 11 3.97e-01 5.85e-01 0.22600 2.24e-01 -2.83e-02 1.98e-01 8.71e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 77 4.97e-03 1.82e-02 0.22600 7.79e-02 2.12e-01 2.38e-01 1.31e-03
Transcriptional regulation of white adipocyte differentiation 81 3.82e-03 1.43e-02 0.22600 7.88e-02 2.11e-01 2.20e-01 1.00e-03
SUMOylation of DNA damage response and repair proteins 74 2.99e-03 1.16e-02 0.22600 6.54e-03 2.26e-01 9.23e-01 7.95e-04
Activation of Matrix Metalloproteinases 31 1.38e-01 2.76e-01 0.22600 -1.33e-01 -1.82e-01 2.01e-01 7.87e-02
ADP signalling through P2Y purinoceptor 1 25 9.37e-02 2.09e-01 0.22500 -1.29e-01 1.84e-01 2.64e-01 1.11e-01
FGFR2 ligand binding and activation 19 2.66e-01 4.44e-01 0.22500 2.14e-01 6.78e-02 1.06e-01 6.09e-01
Binding and Uptake of Ligands by Scavenger Receptors 41 7.32e-02 1.73e-01 0.22500 -1.25e-01 -1.87e-01 1.66e-01 3.87e-02
Tie2 Signaling 18 1.81e-01 3.39e-01 0.22400 -1.70e-01 1.46e-01 2.11e-01 2.85e-01
Degradation of the extracellular matrix 135 1.74e-04 9.30e-04 0.22400 -1.13e-01 -1.94e-01 2.39e-02 1.02e-04
Mitotic Telophase/Cytokinesis 11 3.79e-01 5.68e-01 0.22400 -6.88e-02 2.13e-01 6.93e-01 2.21e-01
ECM proteoglycans 73 9.15e-03 3.14e-02 0.22300 -1.08e-01 -1.96e-01 1.12e-01 3.83e-03
Ribavirin ADME 11 4.37e-01 6.20e-01 0.22300 2.02e-02 2.22e-01 9.08e-01 2.01e-01
MyD88-independent TLR4 cascade 104 1.03e-03 4.76e-03 0.22300 8.77e-02 2.05e-01 1.22e-01 2.96e-04
TRIF (TICAM1)-mediated TLR4 signaling 104 1.03e-03 4.76e-03 0.22300 8.77e-02 2.05e-01 1.22e-01 2.96e-04
Respiratory Syncytial Virus Infection Pathway 110 1.15e-03 5.21e-03 0.22300 1.55e-01 1.60e-01 4.86e-03 3.74e-03
Late endosomal microautophagy 33 1.04e-01 2.26e-01 0.22300 6.70e-02 2.13e-01 5.05e-01 3.46e-02
Translesion synthesis by POLK 17 3.51e-01 5.44e-01 0.22200 1.35e-01 1.76e-01 3.34e-01 2.10e-01
Glutamate and glutamine metabolism 12 3.70e-01 5.60e-01 0.22200 -4.19e-02 2.18e-01 8.02e-01 1.92e-01
Calcitonin-like ligand receptors 10 5.33e-01 6.99e-01 0.22100 -1.10e-01 -1.92e-01 5.48e-01 2.93e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 15 2.62e-01 4.43e-01 0.22000 -1.08e-01 1.91e-01 4.67e-01 1.99e-01
AKT phosphorylates targets in the cytosol 14 4.32e-01 6.18e-01 0.22000 1.63e-01 1.47e-01 2.90e-01 3.42e-01
Uptake and function of anthrax toxins 11 4.11e-01 5.98e-01 0.21900 -2.16e-01 4.00e-02 2.16e-01 8.18e-01
DCC mediated attractive signaling 14 4.29e-01 6.15e-01 0.21900 -1.26e-01 -1.79e-01 4.15e-01 2.45e-01
Inflammasomes 21 2.78e-01 4.54e-01 0.21900 1.15e-01 1.86e-01 3.60e-01 1.40e-01
Pre-NOTCH Processing in Golgi 18 1.99e-01 3.62e-01 0.21900 -1.30e-01 1.76e-01 3.40e-01 1.96e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 4.66e-02 1.23e-01 0.21800 3.53e-02 2.16e-01 6.86e-01 1.34e-02
Nuclear events stimulated by ALK signaling in cancer 34 1.34e-01 2.70e-01 0.21800 1.48e-01 1.60e-01 1.34e-01 1.06e-01
Regulation of CDH11 mRNA translation by microRNAs 11 4.76e-01 6.60e-01 0.21800 -2.12e-01 -5.04e-02 2.23e-01 7.72e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 3.84e-01 5.74e-01 0.21800 4.72e-03 2.18e-01 9.76e-01 1.74e-01
TP53 Regulates Transcription of Cell Death Genes 43 6.22e-02 1.53e-01 0.21800 7.06e-02 2.06e-01 4.23e-01 1.96e-02
GP1b-IX-V activation signalling 11 5.10e-01 6.86e-01 0.21700 -1.03e-01 -1.92e-01 5.56e-01 2.71e-01
HDR through Single Strand Annealing (SSA) 37 1.15e-01 2.40e-01 0.21700 1.59e-01 1.47e-01 9.37e-02 1.21e-01
HDR through Homologous Recombination (HRR) 68 1.84e-02 5.67e-02 0.21700 1.30e-01 1.73e-01 6.30e-02 1.36e-02
Chromatin modifying enzymes 217 2.81e-06 2.14e-05 0.21700 1.20e-01 1.80e-01 2.27e-03 4.75e-06
Chromatin organization 217 2.81e-06 2.14e-05 0.21700 1.20e-01 1.80e-01 2.27e-03 4.75e-06
Amine ligand-binding receptors 40 5.87e-02 1.48e-01 0.21600 -2.16e-01 -1.70e-02 1.82e-02 8.52e-01
RNA Polymerase I Transcription Initiation 45 6.86e-02 1.66e-01 0.21600 1.13e-01 1.84e-01 1.88e-01 3.27e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 54 3.15e-02 8.91e-02 0.21600 2.05e-01 6.65e-02 9.01e-03 3.98e-01
RAB geranylgeranylation 57 3.20e-02 9.00e-02 0.21600 1.01e-01 1.91e-01 1.87e-01 1.27e-02
PI-3K cascade:FGFR1 21 2.44e-01 4.22e-01 0.21600 2.12e-01 4.17e-02 9.33e-02 7.41e-01
Regulation of TP53 Expression and Degradation 37 1.14e-01 2.39e-01 0.21500 1.17e-01 1.81e-01 2.18e-01 5.74e-02
Drug ADME 105 2.18e-03 8.85e-03 0.21500 -1.19e-01 -1.79e-01 3.57e-02 1.50e-03
Apoptosis 172 5.54e-05 3.23e-04 0.21500 1.47e-01 1.56e-01 8.50e-04 4.02e-04
Infectious disease 941 1.89e-23 2.57e-21 0.21500 1.30e-01 1.71e-01 1.43e-11 5.05e-19
Specification of primordial germ cells 11 4.99e-01 6.76e-01 0.21500 6.79e-02 2.04e-01 6.97e-01 2.43e-01
PTEN Regulation 151 4.96e-05 2.92e-04 0.21500 4.43e-02 2.10e-01 3.47e-01 8.49e-06
CRMPs in Sema3A signaling 15 2.77e-01 4.54e-01 0.21400 1.16e-01 -1.80e-01 4.36e-01 2.27e-01
Polymerase switching on the C-strand of the telomere 25 2.10e-01 3.77e-01 0.21400 7.24e-02 2.02e-01 5.31e-01 8.08e-02
Signaling by the B Cell Receptor (BCR) 106 2.43e-03 9.69e-03 0.21400 1.55e-01 1.48e-01 5.84e-03 8.47e-03
SARS-CoV-2-host interactions 190 1.90e-05 1.22e-04 0.21400 1.24e-01 1.74e-01 3.23e-03 3.37e-05
CD28 dependent Vav1 pathway 11 4.81e-01 6.60e-01 0.21300 2.10e-01 3.10e-02 2.27e-01 8.59e-01
Miscellaneous substrates 12 3.71e-01 5.60e-01 0.21200 1.89e-01 -9.77e-02 2.58e-01 5.58e-01
RHOU GTPase cycle 37 8.33e-02 1.91e-01 0.21200 -2.11e-01 -2.47e-02 2.64e-02 7.95e-01
Translocation of ZAP-70 to Immunological synapse 17 2.39e-01 4.16e-01 0.21200 1.22e-01 -1.73e-01 3.83e-01 2.16e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 34 1.41e-01 2.81e-01 0.21200 1.06e-01 1.83e-01 2.84e-01 6.45e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1 11 5.15e-01 6.89e-01 0.21200 7.71e-02 1.97e-01 6.58e-01 2.58e-01
Synthesis of PIPs at the plasma membrane 48 2.88e-02 8.21e-02 0.21100 -2.09e-01 2.93e-02 1.21e-02 7.25e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 43 4.44e-02 1.19e-01 0.21100 -2.11e-01 1.85e-02 1.69e-02 8.34e-01
Citric acid cycle (TCA cycle) 32 1.61e-01 3.09e-01 0.21100 1.08e-01 1.82e-01 2.92e-01 7.51e-02
Presynaptic depolarization and calcium channel opening 12 4.98e-01 6.76e-01 0.21100 -9.62e-02 -1.88e-01 5.64e-01 2.60e-01
Formation of tubulin folding intermediates by CCT/TriC 25 2.14e-01 3.82e-01 0.21100 2.02e-01 6.20e-02 8.08e-02 5.92e-01
Sensory processing of sound by inner hair cells of the cochlea 63 1.80e-02 5.55e-02 0.21100 -4.34e-02 -2.07e-01 5.51e-01 4.58e-03
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 9.73e-02 2.14e-01 0.21100 1.81e-01 1.09e-01 4.53e-02 2.28e-01
Diseases of DNA Double-Strand Break Repair 41 9.73e-02 2.14e-01 0.21100 1.81e-01 1.09e-01 4.53e-02 2.28e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 15 4.35e-01 6.20e-01 0.21100 1.32e-01 1.65e-01 3.77e-01 2.70e-01
Programmed Cell Death 202 1.30e-05 8.50e-05 0.21100 1.19e-01 1.74e-01 3.47e-03 2.04e-05
Signalling to RAS 20 2.17e-01 3.86e-01 0.21100 -5.18e-02 2.04e-01 6.89e-01 1.14e-01
Insulin processing 24 1.98e-01 3.62e-01 0.21100 -2.10e-01 -1.54e-02 7.48e-02 8.96e-01
Regulation of CDH11 gene transcription 10 5.75e-01 7.38e-01 0.21000 1.62e-01 1.34e-01 3.74e-01 4.64e-01
Metabolism of amino acids and derivatives 345 6.74e-09 9.48e-08 0.20900 1.72e-01 1.19e-01 4.00e-08 1.37e-04
Metabolism of porphyrins 27 1.52e-01 2.95e-01 0.20900 9.16e-03 -2.09e-01 9.34e-01 6.00e-02
Regulation of FZD by ubiquitination 21 2.77e-01 4.54e-01 0.20900 5.61e-02 2.01e-01 6.56e-01 1.10e-01
Regulation of TLR by endogenous ligand 21 1.78e-01 3.34e-01 0.20900 -1.61e-01 1.33e-01 2.01e-01 2.92e-01
RHOBTB2 GTPase cycle 22 2.73e-01 4.51e-01 0.20900 1.96e-01 7.20e-02 1.12e-01 5.59e-01
Regulation of CDH11 function 10 5.38e-01 7.05e-01 0.20900 -2.03e-01 -4.76e-02 2.66e-01 7.94e-01
Regulation of TP53 Degradation 36 1.31e-01 2.65e-01 0.20900 9.63e-02 1.85e-01 3.17e-01 5.47e-02
Impaired BRCA2 binding to RAD51 35 1.51e-01 2.94e-01 0.20900 1.57e-01 1.37e-01 1.08e-01 1.59e-01
SUMOylation of DNA methylation proteins 16 2.72e-01 4.50e-01 0.20800 -1.69e-01 1.22e-01 2.41e-01 4.00e-01
Homologous DNA Pairing and Strand Exchange 43 9.37e-02 2.09e-01 0.20800 1.75e-01 1.13e-01 4.72e-02 1.99e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 31 1.64e-01 3.15e-01 0.20800 1.93e-01 7.73e-02 6.23e-02 4.56e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 74 1.88e-02 5.75e-02 0.20800 1.47e-01 1.48e-01 2.88e-02 2.82e-02
RNA Polymerase III Transcription Termination 23 2.89e-01 4.67e-01 0.20800 1.57e-01 1.37e-01 1.93e-01 2.55e-01
RHO GTPases Activate NADPH Oxidases 22 1.67e-01 3.19e-01 0.20800 -1.28e-01 1.64e-01 2.97e-01 1.84e-01
Formation of Fibrin Clot (Clotting Cascade) 37 1.34e-01 2.70e-01 0.20800 -1.69e-01 -1.21e-01 7.51e-02 2.02e-01
MECP2 regulates neuronal receptors and channels 17 3.48e-01 5.41e-01 0.20800 -2.04e-01 -4.21e-02 1.46e-01 7.64e-01
Chondroitin sulfate biosynthesis 18 2.35e-01 4.11e-01 0.20800 -1.13e-01 1.74e-01 4.05e-01 2.01e-01
SUMOylation of intracellular receptors 29 9.42e-02 2.10e-01 0.20800 -1.37e-01 1.56e-01 2.01e-01 1.46e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 1.14e-01 2.39e-01 0.20800 1.71e-01 1.18e-01 6.18e-02 1.95e-01
Cardiogenesis 26 2.01e-01 3.65e-01 0.20800 4.48e-02 2.03e-01 6.93e-01 7.35e-02
Signaling by cytosolic FGFR1 fusion mutants 18 2.72e-01 4.50e-01 0.20800 -3.68e-02 2.04e-01 7.87e-01 1.33e-01
RMTs methylate histone arginines 43 9.93e-02 2.17e-01 0.20800 1.60e-01 1.32e-01 6.86e-02 1.35e-01
Biosynthesis of DHA-derived SPMs 17 2.56e-01 4.36e-01 0.20800 -1.11e-01 1.75e-01 4.27e-01 2.11e-01
RSV-host interactions 88 9.34e-03 3.19e-02 0.20700 1.52e-01 1.41e-01 1.39e-02 2.22e-02
Interconversion of nucleotide di- and triphosphates 29 1.43e-01 2.83e-01 0.20700 -1.53e-03 2.07e-01 9.89e-01 5.40e-02
Signaling by Hedgehog 147 4.23e-04 2.18e-03 0.20700 1.58e-01 1.33e-01 9.70e-04 5.21e-03
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 15 4.16e-01 6.03e-01 0.20600 6.57e-02 1.96e-01 6.59e-01 1.89e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 60 4.04e-02 1.10e-01 0.20600 1.69e-01 1.18e-01 2.36e-02 1.13e-01
Gene expression (Transcription) 1490 4.08e-34 1.33e-31 0.20600 9.74e-02 1.82e-01 3.07e-10 6.91e-32
Maternal to zygotic transition (MZT) 96 5.84e-03 2.12e-02 0.20600 1.73e-01 1.11e-01 3.41e-03 5.91e-02
SHC1 events in EGFR signaling 14 3.39e-01 5.32e-01 0.20600 -9.19e-02 1.84e-01 5.52e-01 2.33e-01
Aggrephagy 40 1.13e-01 2.39e-01 0.20600 1.79e-01 1.01e-01 4.97e-02 2.71e-01
Diseases of DNA repair 51 6.93e-02 1.68e-01 0.20500 1.45e-01 1.46e-01 7.35e-02 7.17e-02
Signaling by FGFR 87 9.58e-03 3.27e-02 0.20500 1.72e-01 1.12e-01 5.47e-03 7.12e-02
Sensory processing of sound by outer hair cells of the cochlea 50 6.17e-02 1.53e-01 0.20500 -8.38e-02 -1.87e-01 3.05e-01 2.19e-02
Initial triggering of complement 21 1.96e-01 3.58e-01 0.20500 1.02e-01 -1.78e-01 4.18e-01 1.58e-01
Heme signaling 45 5.36e-02 1.38e-01 0.20500 -2.05e-01 -4.73e-03 1.74e-02 9.56e-01
Cytosolic sulfonation of small molecules 22 1.79e-01 3.35e-01 0.20500 -1.71e-01 1.13e-01 1.66e-01 3.59e-01
Ethanol oxidation 12 4.40e-01 6.22e-01 0.20400 2.47e-02 -2.03e-01 8.82e-01 2.24e-01
Early SARS-CoV-2 Infection Events 34 1.12e-01 2.38e-01 0.20400 5.53e-03 2.04e-01 9.55e-01 3.98e-02
Integrin cell surface interactions 83 1.20e-02 3.93e-02 0.20400 -1.00e-01 -1.77e-01 1.14e-01 5.25e-03
Sensory processing of sound 70 1.94e-02 5.87e-02 0.20400 -6.83e-02 -1.92e-01 3.23e-01 5.50e-03
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 2.74e-01 4.52e-01 0.20400 1.58e-01 1.28e-01 1.71e-01 2.67e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 2.74e-01 4.52e-01 0.20400 1.58e-01 1.28e-01 1.71e-01 2.67e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 2.74e-01 4.52e-01 0.20400 1.58e-01 1.28e-01 1.71e-01 2.67e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 2.74e-01 4.52e-01 0.20400 1.58e-01 1.28e-01 1.71e-01 2.67e-01
Signaling by FLT3 fusion proteins 19 2.52e-01 4.30e-01 0.20300 -6.24e-02 1.94e-01 6.38e-01 1.44e-01
Germ layer formation at gastrulation 16 4.24e-01 6.09e-01 0.20300 -1.80e-01 -9.41e-02 2.12e-01 5.14e-01
Signaling by FGFR1 51 7.35e-02 1.74e-01 0.20300 1.48e-01 1.39e-01 6.79e-02 8.49e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 1.21e-01 2.49e-01 0.20300 7.15e-02 1.90e-01 4.45e-01 4.30e-02
Interleukin-12 signaling 43 9.45e-02 2.10e-01 0.20300 7.78e-02 1.87e-01 3.77e-01 3.36e-02
Downstream signaling of activated FGFR3 24 2.90e-01 4.68e-01 0.20200 1.16e-01 1.66e-01 3.25e-01 1.60e-01
RNA Polymerase II Transcription 1304 2.13e-28 5.78e-26 0.20100 1.06e-01 1.71e-01 1.43e-10 2.15e-25
Extension of Telomeres 49 7.73e-02 1.82e-01 0.20100 9.76e-02 1.76e-01 2.37e-01 3.30e-02
Glycolysis 72 2.05e-02 6.17e-02 0.20100 7.51e-02 1.86e-01 2.70e-01 6.24e-03
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 4.37e-01 6.20e-01 0.20100 -4.70e-02 1.95e-01 7.78e-01 2.42e-01
alpha-linolenic acid (ALA) metabolism 12 4.37e-01 6.20e-01 0.20100 -4.70e-02 1.95e-01 7.78e-01 2.42e-01
Peroxisomal protein import 62 4.36e-02 1.17e-01 0.20100 1.63e-01 1.17e-01 2.64e-02 1.11e-01
Plasma lipoprotein assembly 19 3.53e-01 5.47e-01 0.20100 -1.89e-01 -6.65e-02 1.53e-01 6.16e-01
Interleukin-15 signaling 13 5.23e-01 6.94e-01 0.20000 1.48e-01 1.35e-01 3.56e-01 3.98e-01
Synthesis of PE 13 4.82e-01 6.60e-01 0.20000 5.41e-02 1.93e-01 7.35e-01 2.29e-01
SUMOylation 170 5.73e-05 3.33e-04 0.20000 3.89e-02 1.96e-01 3.82e-01 9.89e-06
RHOBTB GTPase Cycle 34 1.85e-01 3.44e-01 0.20000 1.50e-01 1.32e-01 1.31e-01 1.81e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 1.08e-02 3.59e-02 0.19900 1.18e-01 1.61e-01 5.15e-02 8.05e-03
Amplification of signal from the kinetochores 91 1.08e-02 3.59e-02 0.19900 1.18e-01 1.61e-01 5.15e-02 8.05e-03
Signaling by FGFR1 in disease 38 1.18e-01 2.44e-01 0.19900 4.67e-02 1.94e-01 6.18e-01 3.87e-02
Maturation of nucleoprotein 9694631 15 3.26e-01 5.14e-01 0.19900 1.53e-01 -1.28e-01 3.06e-01 3.91e-01
Signaling by FGFR2 in disease 42 1.10e-01 2.35e-01 0.19900 1.82e-01 8.10e-02 4.14e-02 3.64e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 8.75e-02 1.99e-01 0.19700 8.77e-02 1.77e-01 2.93e-01 3.43e-02
SHC-mediated cascade:FGFR4 19 3.73e-01 5.62e-01 0.19700 7.45e-02 1.82e-01 5.74e-01 1.69e-01
N-glycan antennae elongation in the medial/trans-Golgi 26 2.18e-01 3.87e-01 0.19700 -1.96e-01 -1.61e-02 8.33e-02 8.87e-01
Lewis blood group biosynthesis 18 4.16e-01 6.03e-01 0.19700 -1.59e-01 -1.16e-01 2.43e-01 3.94e-01
ESR-mediated signaling 183 1.39e-04 7.61e-04 0.19700 1.12e-01 1.62e-01 8.76e-03 1.62e-04
Protein methylation 15 4.42e-01 6.25e-01 0.19600 4.83e-02 1.90e-01 7.46e-01 2.02e-01
Transport of organic anions 10 6.19e-01 7.77e-01 0.19600 -1.55e-01 -1.20e-01 3.97e-01 5.10e-01
PD-1 signaling 21 2.18e-01 3.88e-01 0.19600 1.34e-01 -1.43e-01 2.88e-01 2.57e-01
Common Pathway of Fibrin Clot Formation 21 3.48e-01 5.41e-01 0.19600 -1.77e-01 -8.31e-02 1.60e-01 5.10e-01
DNA strand elongation 31 2.31e-01 4.05e-01 0.19500 1.27e-01 1.48e-01 2.19e-01 1.55e-01
Diseases of hemostasis 17 4.49e-01 6.30e-01 0.19500 -1.36e-01 -1.40e-01 3.32e-01 3.18e-01
Formation of axial mesoderm 14 3.85e-01 5.74e-01 0.19500 1.80e-01 -7.38e-02 2.43e-01 6.33e-01
Toll Like Receptor 9 (TLR9) Cascade 102 5.50e-03 2.01e-02 0.19400 6.74e-02 1.82e-01 2.40e-01 1.46e-03
Formation of the cornified envelope 127 1.14e-03 5.21e-03 0.19400 -4.47e-02 -1.89e-01 3.85e-01 2.34e-04
Signaling by NTRK1 (TRKA) 113 3.40e-03 1.30e-02 0.19400 7.20e-02 1.80e-01 1.86e-01 9.38e-04
Nephrin family interactions 21 3.69e-01 5.60e-01 0.19400 -1.10e-01 -1.60e-01 3.84e-01 2.05e-01
SUMO E3 ligases SUMOylate target proteins 164 1.50e-04 8.18e-04 0.19400 3.84e-02 1.90e-01 3.96e-01 2.71e-05
Triglyceride biosynthesis 13 4.16e-01 6.03e-01 0.19400 7.53e-02 -1.78e-01 6.38e-01 2.65e-01
Glycogen storage diseases 15 4.97e-01 6.76e-01 0.19300 1.52e-01 1.19e-01 3.08e-01 4.26e-01
Extracellular matrix organization 292 1.63e-06 1.29e-05 0.19300 -1.27e-01 -1.45e-01 1.88e-04 2.05e-05
WNT ligand biogenesis and trafficking 25 3.17e-01 5.04e-01 0.19200 1.42e-01 1.30e-01 2.19e-01 2.62e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 20 3.83e-01 5.73e-01 0.19200 8.81e-02 1.71e-01 4.95e-01 1.87e-01
Notch-HLH transcription pathway 24 1.88e-01 3.48e-01 0.19200 -1.36e-01 1.35e-01 2.47e-01 2.52e-01
Transcriptional activation of mitochondrial biogenesis 50 8.10e-02 1.88e-01 0.19200 6.22e-02 1.82e-01 4.47e-01 2.64e-02
Transcriptional regulation by RUNX1 204 7.34e-05 4.17e-04 0.19200 9.79e-02 1.65e-01 1.59e-02 4.96e-05
Myogenesis 29 1.84e-01 3.42e-01 0.19200 -1.91e-01 7.93e-03 7.44e-02 9.41e-01
Dual incision in TC-NER 61 6.21e-02 1.53e-01 0.19100 1.47e-01 1.23e-01 4.75e-02 9.68e-02
SARS-CoV-2 activates/modulates innate and adaptive immune responses 118 3.22e-03 1.24e-02 0.19100 7.40e-02 1.76e-01 1.65e-01 9.30e-04
Lysosphingolipid and LPA receptors 14 5.25e-01 6.95e-01 0.19100 1.56e-01 1.11e-01 3.13e-01 4.71e-01
Serotonin receptors 11 6.01e-01 7.62e-01 0.19100 -1.58e-01 -1.07e-01 3.63e-01 5.38e-01
PI3K events in ERBB4 signaling 10 5.07e-01 6.83e-01 0.19100 1.03e-01 -1.61e-01 5.73e-01 3.78e-01
Regulation of TP53 Activity 155 8.09e-04 3.88e-03 0.19100 1.02e-01 1.61e-01 2.76e-02 5.52e-04
Fc epsilon receptor (FCERI) signaling 127 3.43e-03 1.31e-02 0.19000 1.38e-01 1.31e-01 7.36e-03 1.07e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 2.98e-01 4.78e-01 0.19000 1.31e-01 1.38e-01 2.39e-01 2.15e-01
O-glycosylation of TSR domain-containing proteins 38 1.47e-01 2.89e-01 0.19000 -5.12e-02 -1.83e-01 5.85e-01 5.10e-02
Resolution of D-loop Structures through Holliday Junction Intermediates 34 2.19e-01 3.88e-01 0.18900 1.18e-01 1.48e-01 2.35e-01 1.35e-01
Blood group systems biosynthesis 22 3.72e-01 5.61e-01 0.18900 -1.54e-01 -1.09e-01 2.10e-01 3.77e-01
Defective B3GALTL causes PpS 37 1.68e-01 3.20e-01 0.18900 -6.43e-02 -1.77e-01 4.99e-01 6.20e-02
Signaling by NODAL 20 2.67e-01 4.45e-01 0.18800 1.10e-01 -1.53e-01 3.97e-01 2.37e-01
Synthesis of substrates in N-glycan biosythesis 63 5.20e-02 1.35e-01 0.18800 7.13e-02 1.73e-01 3.27e-01 1.73e-02
NR1H2 and NR1H3-mediated signaling 53 6.21e-02 1.53e-01 0.18700 -1.86e-01 -2.09e-02 1.90e-02 7.92e-01
Generic Transcription Pathway 1185 1.19e-22 1.39e-20 0.18700 9.77e-02 1.60e-01 1.44e-08 1.57e-20
Signaling by Leptin 11 6.11e-01 7.71e-01 0.18700 1.60e-01 9.76e-02 3.59e-01 5.75e-01
Chylomicron assembly 10 6.38e-01 7.88e-01 0.18700 -9.61e-02 -1.61e-01 5.99e-01 3.79e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 24 3.37e-01 5.30e-01 0.18700 -1.64e-01 -8.95e-02 1.63e-01 4.48e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 5.06e-01 6.83e-01 0.18700 -6.23e-02 1.76e-01 7.21e-01 3.11e-01
MAP kinase activation 58 6.40e-02 1.57e-01 0.18700 6.27e-02 1.76e-01 4.09e-01 2.04e-02
Type I hemidesmosome assembly 11 5.84e-01 7.46e-01 0.18600 -4.57e-02 -1.80e-01 7.93e-01 3.00e-01
TNFs bind their physiological receptors 25 3.26e-01 5.15e-01 0.18600 1.64e-01 8.77e-02 1.56e-01 4.48e-01
Resolution of Abasic Sites (AP sites) 38 1.44e-01 2.85e-01 0.18600 2.41e-02 1.84e-01 7.97e-01 4.97e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade 98 1.04e-02 3.52e-02 0.18600 6.33e-02 1.74e-01 2.79e-01 2.85e-03
PI3K events in ERBB2 signaling 16 3.56e-01 5.51e-01 0.18500 1.19e-01 -1.41e-01 4.08e-01 3.28e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 5.25e-01 6.95e-01 0.18500 -1.18e-01 1.42e-01 5.18e-01 4.36e-01
RHOQ GTPase cycle 57 5.78e-02 1.46e-01 0.18500 -1.83e-01 -2.74e-02 1.71e-02 7.21e-01
Crosslinking of collagen fibrils 16 3.92e-01 5.79e-01 0.18400 4.57e-02 -1.79e-01 7.52e-01 2.16e-01
LGI-ADAM interactions 14 5.54e-01 7.18e-01 0.18400 1.25e-01 1.36e-01 4.19e-01 3.79e-01
Inositol phosphate metabolism 45 1.40e-01 2.80e-01 0.18400 -1.62e-01 -8.78e-02 6.08e-02 3.08e-01
Syndecan interactions 26 3.34e-01 5.25e-01 0.18400 -1.43e-01 -1.15e-01 2.07e-01 3.08e-01
Resolution of D-Loop Structures 35 2.26e-01 3.98e-01 0.18400 1.06e-01 1.50e-01 2.80e-01 1.24e-01
Zinc influx into cells by the SLC39 gene family 10 6.58e-01 8.01e-01 0.18400 1.35e-01 1.24e-01 4.60e-01 4.96e-01
ERK/MAPK targets 20 3.85e-01 5.74e-01 0.18400 4.30e-02 1.78e-01 7.39e-01 1.67e-01
Interferon alpha/beta signaling 74 3.19e-02 8.99e-02 0.18300 1.76e-01 5.29e-02 8.98e-03 4.31e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 13 5.72e-01 7.35e-01 0.18300 -1.57e-01 -9.51e-02 3.28e-01 5.53e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 3.90e-01 5.77e-01 0.18300 -2.37e-02 1.82e-01 8.66e-01 1.94e-01
mRNA Editing 10 5.90e-01 7.53e-01 0.18300 8.18e-04 -1.83e-01 9.96e-01 3.16e-01
trans-Golgi Network Vesicle Budding 67 2.64e-02 7.65e-02 0.18300 -1.88e-02 1.82e-01 7.91e-01 1.02e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 106 6.21e-03 2.22e-02 0.18200 3.36e-02 1.79e-01 5.50e-01 1.44e-03
Toll Like Receptor TLR6:TLR2 Cascade 106 6.21e-03 2.22e-02 0.18200 3.36e-02 1.79e-01 5.50e-01 1.44e-03
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 2.58e-01 4.37e-01 0.18200 5.97e-02 1.72e-01 5.72e-01 1.03e-01
Adipogenesis 105 9.18e-03 3.15e-02 0.18200 6.30e-02 1.71e-01 2.65e-01 2.51e-03
Cellular hexose transport 22 3.05e-01 4.89e-01 0.18200 1.81e-01 -1.90e-02 1.42e-01 8.77e-01
Resolution of Sister Chromatid Cohesion 119 7.12e-03 2.51e-02 0.18100 9.96e-02 1.52e-01 6.07e-02 4.26e-03
Signaling by PDGFR in disease 20 2.96e-01 4.76e-01 0.18100 -1.51e-01 9.96e-02 2.43e-01 4.41e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 3.58e-01 5.52e-01 0.18000 1.49e-01 1.02e-01 1.98e-01 3.77e-01
SARS-CoV Infections 391 5.33e-08 5.88e-07 0.18000 6.84e-02 1.67e-01 2.01e-02 1.45e-08
NCAM1 interactions 41 1.13e-01 2.39e-01 0.18000 1.93e-02 -1.79e-01 8.31e-01 4.69e-02
Potential therapeutics for SARS 92 1.12e-02 3.70e-02 0.18000 1.48e-02 1.79e-01 8.06e-01 2.95e-03
MyD88 dependent cascade initiated on endosome 96 1.57e-02 4.93e-02 0.18000 6.52e-02 1.67e-01 2.70e-01 4.60e-03
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 54 1.08e-01 2.32e-01 0.17900 9.16e-02 1.54e-01 2.44e-01 4.98e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants 54 1.08e-01 2.32e-01 0.17900 9.16e-02 1.54e-01 2.44e-01 4.98e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 54 1.08e-01 2.32e-01 0.17900 9.16e-02 1.54e-01 2.44e-01 4.98e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer 54 1.08e-01 2.32e-01 0.17900 9.16e-02 1.54e-01 2.44e-01 4.98e-02
Signaling by NOTCH1 in Cancer 54 1.08e-01 2.32e-01 0.17900 9.16e-02 1.54e-01 2.44e-01 4.98e-02
SHC-mediated cascade:FGFR2 22 4.02e-01 5.89e-01 0.17900 8.78e-02 1.56e-01 4.76e-01 2.04e-01
Disorders of transmembrane transporters 170 1.15e-03 5.21e-03 0.17900 1.39e-01 1.13e-01 1.79e-03 1.08e-02
Toll-like Receptor Cascades 161 6.60e-04 3.27e-03 0.17900 3.71e-02 1.75e-01 4.16e-01 1.30e-04
MyD88 cascade initiated on plasma membrane 91 2.08e-02 6.24e-02 0.17800 6.63e-02 1.66e-01 2.74e-01 6.34e-03
Toll Like Receptor 10 (TLR10) Cascade 91 2.08e-02 6.24e-02 0.17800 6.63e-02 1.66e-01 2.74e-01 6.34e-03
Toll Like Receptor 5 (TLR5) Cascade 91 2.08e-02 6.24e-02 0.17800 6.63e-02 1.66e-01 2.74e-01 6.34e-03
Synthesis of IP2, IP, and Ins in the cytosol 13 5.48e-01 7.13e-01 0.17800 -1.76e-01 -3.03e-02 2.73e-01 8.50e-01
Molecules associated with elastic fibres 37 1.66e-01 3.17e-01 0.17800 -1.78e-01 -8.26e-03 6.13e-02 9.31e-01
Asparagine N-linked glycosylation 300 3.70e-06 2.76e-05 0.17700 6.42e-02 1.65e-01 5.56e-02 8.78e-07
Pyroptosis 27 2.09e-01 3.76e-01 0.17700 -8.91e-02 1.53e-01 4.23e-01 1.69e-01
Signaling by WNT 288 1.60e-05 1.03e-04 0.17700 1.15e-01 1.34e-01 7.59e-04 9.46e-05
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 5.68e-01 7.31e-01 0.17600 -2.38e-02 1.75e-01 8.91e-01 3.16e-01
Interleukin-1 family signaling 147 3.52e-03 1.33e-02 0.17600 1.32e-01 1.17e-01 5.88e-03 1.41e-02
Phosphorylation of CD3 and TCR zeta chains 20 3.20e-01 5.06e-01 0.17600 1.56e-01 -8.27e-02 2.28e-01 5.22e-01
O-linked glycosylation 110 1.19e-02 3.92e-02 0.17600 -1.57e-01 -8.01e-02 4.48e-03 1.47e-01
Organic cation transport 10 5.60e-01 7.23e-01 0.17600 -1.41e-01 1.05e-01 4.39e-01 5.67e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 21 3.99e-01 5.87e-01 0.17600 1.71e-01 4.22e-02 1.76e-01 7.38e-01
Retinoid metabolism and transport 42 1.37e-01 2.75e-01 0.17500 -6.31e-03 -1.75e-01 9.44e-01 4.96e-02
FLT3 Signaling 38 2.36e-01 4.11e-01 0.17500 1.22e-01 1.25e-01 1.92e-01 1.82e-01
Vitamin B5 (pantothenate) metabolism 19 4.62e-01 6.44e-01 0.17400 6.55e-02 1.61e-01 6.21e-01 2.23e-01
GRB2 events in EGFR signaling 13 4.74e-01 6.58e-01 0.17400 -1.17e-01 1.29e-01 4.63e-01 4.22e-01
Glycosphingolipid catabolism 33 2.56e-01 4.36e-01 0.17400 5.71e-02 1.64e-01 5.70e-01 1.02e-01
Signaling by NTRKs 132 5.35e-03 1.96e-02 0.17400 7.27e-02 1.58e-01 1.49e-01 1.74e-03
EML4 and NUDC in mitotic spindle formation 112 1.50e-02 4.74e-02 0.17400 1.11e-01 1.34e-01 4.28e-02 1.44e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 95 2.14e-02 6.37e-02 0.17300 6.07e-02 1.62e-01 3.06e-01 6.26e-03
Beta-catenin phosphorylation cascade 16 4.49e-01 6.30e-01 0.17300 -2.84e-02 1.71e-01 8.44e-01 2.37e-01
Regulation of beta-cell development 41 2.14e-01 3.82e-01 0.17300 1.01e-01 1.41e-01 2.64e-01 1.19e-01
Antimicrobial peptides 78 1.66e-02 5.17e-02 0.17300 1.64e-01 -5.50e-02 1.23e-02 4.01e-01
Negative regulation of MET activity 20 3.63e-01 5.57e-01 0.17300 -3.50e-02 1.69e-01 7.86e-01 1.90e-01
Aflatoxin activation and detoxification 19 3.58e-01 5.52e-01 0.17200 7.49e-02 -1.55e-01 5.72e-01 2.41e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 53 8.89e-02 2.01e-01 0.17200 6.49e-03 1.72e-01 9.35e-01 3.02e-02
FCERI mediated MAPK activation 32 1.75e-01 3.31e-01 0.17200 -1.51e-01 8.27e-02 1.39e-01 4.18e-01
Metabolism of nucleotides 93 1.60e-02 5.01e-02 0.17200 1.52e-02 1.71e-01 8.00e-01 4.31e-03
Glycogen synthesis 13 6.15e-01 7.75e-01 0.17200 9.57e-02 1.43e-01 5.50e-01 3.73e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 14 5.99e-01 7.60e-01 0.17200 -1.16e-01 -1.27e-01 4.52e-01 4.12e-01
Glucose metabolism 83 4.41e-02 1.18e-01 0.17200 8.73e-02 1.48e-01 1.69e-01 2.00e-02
PKR-mediated signaling 70 7.91e-02 1.85e-01 0.17100 1.26e-01 1.16e-01 6.87e-02 9.38e-02
InlB-mediated entry of Listeria monocytogenes into host cell 14 6.03e-01 7.63e-01 0.17100 1.14e-01 1.27e-01 4.61e-01 4.11e-01
Constitutive Signaling by EGFRvIII 15 5.82e-01 7.45e-01 0.17000 1.25e-01 1.16e-01 4.01e-01 4.38e-01
Signaling by EGFRvIII in Cancer 15 5.82e-01 7.45e-01 0.17000 1.25e-01 1.16e-01 4.01e-01 4.38e-01
Signaling by FGFR in disease 62 1.07e-01 2.32e-01 0.17000 1.22e-01 1.19e-01 9.76e-02 1.04e-01
Depolymerization of the Nuclear Lamina 14 5.12e-01 6.86e-01 0.17000 -2.16e-02 1.69e-01 8.89e-01 2.73e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 51 1.55e-01 3.00e-01 0.17000 9.81e-02 1.39e-01 2.25e-01 8.55e-02
Pentose phosphate pathway 12 5.23e-01 6.94e-01 0.17000 -1.01e-01 1.36e-01 5.45e-01 4.14e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 6.03e-01 7.63e-01 0.17000 5.92e-02 1.59e-01 7.12e-01 3.21e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 76 5.25e-02 1.35e-01 0.17000 5.94e-02 1.59e-01 3.71e-01 1.67e-02
Sodium/Calcium exchangers 11 5.55e-01 7.18e-01 0.16900 1.41e-01 -9.46e-02 4.19e-01 5.87e-01
tRNA modification in the nucleus and cytosol 41 2.32e-01 4.05e-01 0.16900 1.28e-01 1.11e-01 1.55e-01 2.20e-01
G-protein activation 24 2.86e-01 4.63e-01 0.16900 -7.32e-02 1.53e-01 5.35e-01 1.95e-01
Tight junction interactions 28 3.42e-01 5.34e-01 0.16900 -6.43e-02 -1.57e-01 5.56e-01 1.51e-01
Advanced glycosylation endproduct receptor signaling 13 6.10e-01 7.70e-01 0.16900 1.55e-01 6.85e-02 3.34e-01 6.69e-01
Downstream signaling of activated FGFR1 31 3.17e-01 5.04e-01 0.16900 1.50e-01 7.90e-02 1.50e-01 4.47e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 4.09e-01 5.97e-01 0.16900 1.02e-01 1.35e-01 3.77e-01 2.44e-01
Toll Like Receptor 4 (TLR4) Cascade 139 4.55e-03 1.69e-02 0.16800 4.98e-02 1.60e-01 3.11e-01 1.09e-03
mRNA decay by 5’ to 3’ exoribonuclease 15 5.40e-01 7.06e-01 0.16800 2.83e-02 1.66e-01 8.50e-01 2.67e-01
Receptor-type tyrosine-protein phosphatases 16 4.75e-01 6.58e-01 0.16800 2.27e-02 -1.66e-01 8.75e-01 2.50e-01
RHOF GTPase cycle 40 2.45e-01 4.22e-01 0.16700 -9.62e-02 -1.37e-01 2.93e-01 1.35e-01
SUMOylation of transcription cofactors 44 1.45e-01 2.87e-01 0.16700 -3.83e-03 1.67e-01 9.65e-01 5.59e-02
N-Glycan antennae elongation 15 4.56e-01 6.38e-01 0.16600 -1.21e-01 1.14e-01 4.15e-01 4.45e-01
Synthesis of PA 38 2.65e-01 4.44e-01 0.16600 -9.44e-02 -1.37e-01 3.14e-01 1.44e-01
Lysine catabolism 12 6.47e-01 7.95e-01 0.16600 -1.50e-01 -7.25e-02 3.70e-01 6.64e-01
Activation of gene expression by SREBF (SREBP) 41 1.47e-01 2.88e-01 0.16600 -3.49e-02 1.62e-01 6.99e-01 7.20e-02
FRS-mediated FGFR4 signaling 21 4.81e-01 6.60e-01 0.16500 8.54e-02 1.41e-01 4.98e-01 2.62e-01
Interleukin-12 family signaling 53 1.51e-01 2.95e-01 0.16500 7.10e-02 1.49e-01 3.71e-01 6.09e-02
RAS processing 23 4.36e-01 6.20e-01 0.16500 6.37e-02 1.52e-01 5.97e-01 2.08e-01
Mitotic Prometaphase 193 1.18e-03 5.27e-03 0.16400 7.17e-02 1.47e-01 8.58e-02 4.12e-04
Sealing of the nuclear envelope (NE) by ESCRT-III 30 3.65e-01 5.58e-01 0.16400 1.01e-01 1.29e-01 3.40e-01 2.21e-01
Antigen processing: Ubiquitination & Proteasome degradation 295 3.77e-05 2.27e-04 0.16400 7.44e-02 1.46e-01 2.79e-02 1.62e-05
Erythropoietin activates RAS 14 5.51e-01 7.16e-01 0.16400 -5.79e-03 1.64e-01 9.70e-01 2.89e-01
PI Metabolism 78 2.80e-02 8.02e-02 0.16400 -1.59e-01 3.85e-02 1.51e-02 5.56e-01
Keratan sulfate biosynthesis 28 3.60e-01 5.53e-01 0.16300 -1.55e-01 -5.23e-02 1.56e-01 6.32e-01
Retrograde neurotrophin signalling 14 6.28e-01 7.81e-01 0.16300 1.08e-01 1.23e-01 4.85e-01 4.26e-01
FGFR2b ligand binding and activation 10 6.10e-01 7.70e-01 0.16300 1.39e-01 -8.50e-02 4.46e-01 6.41e-01
CS/DS degradation 12 5.53e-01 7.18e-01 0.16300 -8.84e-02 1.37e-01 5.96e-01 4.12e-01
Toll Like Receptor 2 (TLR2) Cascade 109 1.77e-02 5.49e-02 0.16200 3.79e-02 1.57e-01 4.94e-01 4.54e-03
Toll Like Receptor TLR1:TLR2 Cascade 109 1.77e-02 5.49e-02 0.16200 3.79e-02 1.57e-01 4.94e-01 4.54e-03
Interferon Signaling 257 2.61e-04 1.36e-03 0.16200 1.10e-01 1.18e-01 2.35e-03 1.09e-03
Regulation of localization of FOXO transcription factors 11 7.01e-01 8.29e-01 0.16100 -1.22e-01 -1.05e-01 4.84e-01 5.45e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 37 1.67e-01 3.19e-01 0.16100 -1.29e-01 9.56e-02 1.74e-01 3.14e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 3.43e-01 5.36e-01 0.16100 1.53e-01 4.74e-02 1.46e-01 6.53e-01
Kidney development 45 1.77e-01 3.34e-01 0.16000 1.77e-02 1.59e-01 8.37e-01 6.42e-02
Beta-catenin independent WNT signaling 145 1.03e-02 3.47e-02 0.16000 1.18e-01 1.08e-01 1.43e-02 2.46e-02
Class I MHC mediated antigen processing & presentation 363 6.11e-06 4.27e-05 0.16000 6.84e-02 1.44e-01 2.53e-02 2.26e-06
RHO GTPase Effectors 274 1.87e-04 9.95e-04 0.16000 1.09e-01 1.16e-01 1.85e-03 9.03e-04
SARS-CoV-2 Infection 280 1.16e-04 6.43e-04 0.16000 8.04e-02 1.38e-01 2.05e-02 7.07e-05
Neurexins and neuroligins 52 1.90e-01 3.50e-01 0.16000 -9.51e-02 -1.28e-01 2.35e-01 1.10e-01
Regulation of MITF-M-dependent genes involved in apoptosis 19 5.11e-01 6.86e-01 0.16000 -1.53e-01 -4.50e-02 2.48e-01 7.34e-01
Synthesis of IP3 and IP4 in the cytosol 25 4.55e-01 6.38e-01 0.15900 -1.13e-01 -1.12e-01 3.29e-01 3.31e-01
Disorders of Developmental Biology 11 6.33e-01 7.84e-01 0.15900 -1.81e-02 1.58e-01 9.17e-01 3.64e-01
Disorders of Nervous System Development 11 6.33e-01 7.84e-01 0.15900 -1.81e-02 1.58e-01 9.17e-01 3.64e-01
Loss of function of MECP2 in Rett syndrome 11 6.33e-01 7.84e-01 0.15900 -1.81e-02 1.58e-01 9.17e-01 3.64e-01
Pervasive developmental disorders 11 6.33e-01 7.84e-01 0.15900 -1.81e-02 1.58e-01 9.17e-01 3.64e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 5.92e-01 7.55e-01 0.15900 -4.06e-02 1.54e-01 8.08e-01 3.56e-01
Metabolism of proteins 1919 7.42e-25 1.21e-22 0.15800 9.21e-02 1.29e-01 2.34e-11 8.28e-21
Regulated proteolysis of p75NTR 11 6.34e-01 7.85e-01 0.15800 1.57e-01 -2.09e-02 3.68e-01 9.05e-01
Post-translational protein phosphorylation 100 4.26e-02 1.15e-01 0.15800 -1.33e-01 -8.51e-02 2.16e-02 1.41e-01
Metabolism of fat-soluble vitamins 46 1.47e-01 2.88e-01 0.15800 2.81e-02 -1.55e-01 7.42e-01 6.87e-02
The phototransduction cascade 32 3.68e-01 5.59e-01 0.15700 -8.91e-02 -1.30e-01 3.83e-01 2.04e-01
MAP2K and MAPK activation 38 2.75e-01 4.53e-01 0.15700 4.87e-02 1.49e-01 6.04e-01 1.11e-01
MAPK targets/ Nuclear events mediated by MAP kinases 29 3.74e-01 5.62e-01 0.15700 4.80e-02 1.49e-01 6.55e-01 1.64e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 20 5.29e-01 6.98e-01 0.15700 7.31e-02 1.39e-01 5.71e-01 2.84e-01
ABC transporters in lipid homeostasis 17 5.71e-01 7.35e-01 0.15600 -5.72e-02 -1.46e-01 6.83e-01 2.99e-01
Scavenging by Class A Receptors 19 5.30e-01 6.99e-01 0.15600 -5.08e-02 -1.48e-01 7.01e-01 2.65e-01
Deactivation of the beta-catenin transactivating complex 39 2.78e-01 4.54e-01 0.15600 5.66e-02 1.46e-01 5.41e-01 1.16e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 4.00e-01 5.87e-01 0.15600 1.53e-02 1.55e-01 8.95e-01 1.79e-01
FRS-mediated FGFR2 signaling 24 4.82e-01 6.60e-01 0.15600 9.62e-02 1.23e-01 4.14e-01 2.98e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 28 4.12e-01 6.00e-01 0.15500 -1.40e-01 -6.63e-02 1.99e-01 5.43e-01
Signalling to ERKs 34 2.46e-01 4.23e-01 0.15500 -3.70e-02 1.51e-01 7.09e-01 1.29e-01
Termination of translesion DNA synthesis 32 3.75e-01 5.62e-01 0.15500 8.03e-02 1.33e-01 4.32e-01 1.94e-01
Signaling by ALK fusions and activated point mutants 91 4.45e-02 1.19e-01 0.15500 3.17e-02 1.51e-01 6.01e-01 1.26e-02
Signaling by ALK in cancer 91 4.45e-02 1.19e-01 0.15500 3.17e-02 1.51e-01 6.01e-01 1.26e-02
Prostacyclin signalling through prostacyclin receptor 19 4.80e-01 6.60e-01 0.15400 -1.34e-02 1.54e-01 9.19e-01 2.46e-01
Phase 4 - resting membrane potential 19 5.56e-01 7.19e-01 0.15400 -7.14e-02 -1.37e-01 5.90e-01 3.02e-01
Synthesis of very long-chain fatty acyl-CoAs 23 4.79e-01 6.60e-01 0.15400 -5.62e-02 -1.44e-01 6.41e-01 2.33e-01
Maturation of spike protein 9694548 35 2.28e-01 4.01e-01 0.15400 -5.44e-02 1.44e-01 5.77e-01 1.40e-01
Mismatch Repair 15 6.31e-01 7.83e-01 0.15400 7.17e-02 1.36e-01 6.31e-01 3.62e-01
MicroRNA (miRNA) biogenesis 26 4.18e-01 6.04e-01 0.15400 1.50e-01 3.53e-02 1.87e-01 7.55e-01
Phospholipase C-mediated cascade; FGFR2 17 5.82e-01 7.46e-01 0.15300 1.44e-01 5.34e-02 3.05e-01 7.03e-01
Formation of the nephric duct 17 5.33e-01 7.00e-01 0.15300 -2.25e-03 1.53e-01 9.87e-01 2.74e-01
Disease 1706 2.87e-21 2.76e-19 0.15300 8.07e-02 1.30e-01 2.88e-08 3.18e-19
Triglyceride metabolism 36 2.79e-01 4.55e-01 0.15300 -1.25e-02 -1.53e-01 8.96e-01 1.13e-01
Phospholipase C-mediated cascade; FGFR4 14 6.51e-01 7.96e-01 0.15300 1.38e-01 6.66e-02 3.73e-01 6.66e-01
Telomere C-strand (Lagging Strand) Synthesis 33 3.40e-01 5.32e-01 0.15300 3.97e-02 1.47e-01 6.93e-01 1.43e-01
Regulation of PLK1 Activity at G2/M Transition 84 6.98e-02 1.68e-01 0.15300 5.07e-02 1.44e-01 4.22e-01 2.25e-02
Peroxisomal lipid metabolism 28 4.47e-01 6.29e-01 0.15200 1.08e-01 1.07e-01 3.21e-01 3.27e-01
Downstream signaling of activated FGFR4 26 4.74e-01 6.58e-01 0.15200 9.69e-02 1.17e-01 3.92e-01 3.02e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 20 4.98e-01 6.76e-01 0.15200 1.14e-02 1.51e-01 9.30e-01 2.42e-01
Downregulation of ERBB2 signaling 29 4.37e-01 6.20e-01 0.15100 1.17e-01 9.64e-02 2.77e-01 3.69e-01
Glucagon signaling in metabolic regulation 32 2.78e-01 4.54e-01 0.15100 -4.59e-02 1.44e-01 6.53e-01 1.59e-01
Triglyceride catabolism 23 4.99e-01 6.76e-01 0.15100 -6.22e-02 -1.38e-01 6.05e-01 2.53e-01
EGFR downregulation 30 4.25e-01 6.10e-01 0.15100 9.25e-02 1.19e-01 3.81e-01 2.58e-01
RHO GTPases Activate Formins 134 2.32e-02 6.87e-02 0.15100 1.07e-01 1.06e-01 3.26e-02 3.35e-02
RHOB GTPase cycle 66 1.44e-01 2.85e-01 0.15100 -1.33e-01 -7.05e-02 6.17e-02 3.22e-01
Growth hormone receptor signaling 24 3.99e-01 5.87e-01 0.15000 2.91e-02 -1.48e-01 8.05e-01 2.11e-01
Creation of C4 and C2 activators 14 6.18e-01 7.77e-01 0.15000 -8.43e-03 -1.50e-01 9.56e-01 3.32e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 3.68e-01 5.59e-01 0.15000 1.06e-01 1.06e-01 2.72e-01 2.72e-01
RND2 GTPase cycle 41 2.78e-01 4.54e-01 0.15000 -1.44e-01 -4.11e-02 1.11e-01 6.48e-01
Acyl chain remodelling of PG 18 4.87e-01 6.64e-01 0.15000 5.41e-02 -1.39e-01 6.91e-01 3.06e-01
Inactivation, recovery and regulation of the phototransduction cascade 31 4.22e-01 6.08e-01 0.14900 -9.56e-02 -1.15e-01 3.57e-01 2.69e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 4.22e-01 6.08e-01 0.14900 7.30e-02 1.30e-01 4.89e-01 2.17e-01
Regulation of TP53 Activity through Acetylation 28 3.37e-01 5.30e-01 0.14900 -4.37e-02 1.42e-01 6.89e-01 1.92e-01
Interleukin-17 signaling 66 9.58e-02 2.12e-01 0.14900 -1.06e-02 1.48e-01 8.82e-01 3.73e-02
AURKA Activation by TPX2 69 1.41e-01 2.80e-01 0.14900 7.19e-02 1.30e-01 3.02e-01 6.18e-02
Metabolism of steroid hormones 35 2.74e-01 4.52e-01 0.14800 2.69e-02 -1.46e-01 7.83e-01 1.35e-01
Glutathione synthesis and recycling 12 6.57e-01 8.01e-01 0.14800 -7.13e-03 1.48e-01 9.66e-01 3.75e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11 6.56e-01 8.00e-01 0.14800 1.41e-01 -4.43e-02 4.18e-01 7.99e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 6.55e-01 7.99e-01 0.14800 4.26e-02 1.41e-01 7.83e-01 3.60e-01
Downstream signaling of activated FGFR2 29 4.57e-01 6.40e-01 0.14800 1.05e-01 1.04e-01 3.29e-01 3.33e-01
Transport of connexons to the plasma membrane 19 5.19e-01 6.92e-01 0.14700 1.47e-01 -5.06e-03 2.66e-01 9.70e-01
Glutamate Neurotransmitter Release Cycle 24 4.45e-01 6.26e-01 0.14700 1.47e-01 2.42e-03 2.12e-01 9.84e-01
Ubiquinol biosynthesis 13 6.87e-01 8.20e-01 0.14700 5.78e-02 1.35e-01 7.18e-01 3.98e-01
FGFR3 ligand binding and activation 12 7.25e-01 8.46e-01 0.14700 1.01e-01 1.06e-01 5.43e-01 5.24e-01
FGFR3c ligand binding and activation 12 7.25e-01 8.46e-01 0.14700 1.01e-01 1.06e-01 5.43e-01 5.24e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 12 6.49e-01 7.96e-01 0.14700 -2.41e-02 1.45e-01 8.85e-01 3.85e-01
Death Receptor Signaling 144 2.15e-02 6.40e-02 0.14700 1.11e-01 9.63e-02 2.17e-02 4.61e-02
Apoptotic execution phase 49 2.01e-01 3.65e-01 0.14600 7.15e-03 1.46e-01 9.31e-01 7.71e-02
PI-3K cascade:FGFR3 17 6.29e-01 7.82e-01 0.14500 1.27e-01 6.99e-02 3.64e-01 6.18e-01
Interleukin-6 signaling 11 6.50e-01 7.96e-01 0.14500 7.83e-02 -1.22e-01 6.53e-01 4.83e-01
Activation of AMPK downstream of NMDARs 27 4.79e-01 6.60e-01 0.14500 1.29e-01 6.53e-02 2.46e-01 5.57e-01
Pregnenolone biosynthesis 12 7.23e-01 8.45e-01 0.14500 6.90e-02 1.27e-01 6.79e-01 4.46e-01
Acyl chain remodelling of PC 27 3.68e-01 5.59e-01 0.14400 5.27e-02 -1.34e-01 6.35e-01 2.28e-01
ADP signalling through P2Y purinoceptor 12 22 4.38e-01 6.20e-01 0.14400 -6.01e-02 1.31e-01 6.25e-01 2.89e-01
Leading Strand Synthesis 13 7.16e-01 8.40e-01 0.14400 1.08e-01 9.49e-02 5.00e-01 5.54e-01
Polymerase switching 13 7.16e-01 8.40e-01 0.14400 1.08e-01 9.49e-02 5.00e-01 5.54e-01
Apoptotic cleavage of cellular proteins 35 2.58e-01 4.37e-01 0.14400 -1.15e-01 8.58e-02 2.38e-01 3.80e-01
Evasion by RSV of host interferon responses 31 3.61e-01 5.55e-01 0.14300 1.43e-01 -7.13e-03 1.68e-01 9.45e-01
G alpha (s) signalling events 155 1.94e-02 5.87e-02 0.14300 -1.13e-01 -8.80e-02 1.54e-02 5.87e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 20 5.96e-01 7.58e-01 0.14300 1.20e-01 7.72e-02 3.52e-01 5.50e-01
Transcriptional Regulation by MECP2 60 1.31e-01 2.66e-01 0.14200 -1.39e-01 2.75e-02 6.27e-02 7.13e-01
G beta:gamma signalling through PI3Kgamma 25 4.10e-01 5.98e-01 0.14100 -5.20e-02 1.31e-01 6.53e-01 2.56e-01
Association of TriC/CCT with target proteins during biosynthesis 38 3.88e-01 5.76e-01 0.14100 1.14e-01 8.20e-02 2.22e-01 3.82e-01
Elastic fibre formation 44 2.36e-01 4.11e-01 0.14100 -1.39e-01 2.15e-02 1.11e-01 8.05e-01
Cell-cell junction organization 88 1.09e-01 2.32e-01 0.14000 -7.18e-02 -1.21e-01 2.44e-01 5.02e-02
Reduction of cytosolic Ca++ levels 11 6.66e-01 8.06e-01 0.14000 8.02e-02 -1.15e-01 6.45e-01 5.08e-01
Amino acids regulate mTORC1 51 2.21e-01 3.91e-01 0.14000 1.24e-02 1.40e-01 8.79e-01 8.45e-02
PIWI-interacting RNA (piRNA) biogenesis 29 4.44e-01 6.25e-01 0.13900 1.37e-01 2.68e-02 2.02e-01 8.03e-01
VEGFA-VEGFR2 Pathway 95 3.16e-02 8.92e-02 0.13900 -1.10e-01 8.59e-02 6.47e-02 1.48e-01
Activated point mutants of FGFR2 16 6.60e-01 8.02e-01 0.13900 1.29e-01 5.08e-02 3.71e-01 7.25e-01
Circadian Clock 66 9.41e-02 2.10e-01 0.13900 -1.16e-01 7.65e-02 1.04e-01 2.82e-01
Reproduction 119 5.77e-02 1.46e-01 0.13800 1.12e-01 8.21e-02 3.56e-02 1.22e-01
Incretin synthesis, secretion, and inactivation 23 5.32e-01 6.99e-01 0.13800 2.64e-02 1.35e-01 8.26e-01 2.61e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 6.63e-01 8.04e-01 0.13800 -1.27e-01 5.41e-02 4.47e-01 7.46e-01
Visual phototransduction 93 9.49e-02 2.10e-01 0.13800 -5.15e-02 -1.28e-01 3.90e-01 3.33e-02
GABA synthesis, release, reuptake and degradation 19 5.12e-01 6.86e-01 0.13800 7.45e-02 -1.16e-01 5.74e-01 3.82e-01
Diseases of signal transduction by growth factor receptors and second messengers 449 1.26e-05 8.25e-05 0.13700 4.75e-02 1.29e-01 8.43e-02 2.77e-06
Synthesis of PC 27 4.38e-01 6.20e-01 0.13700 -1.19e-02 1.37e-01 9.14e-01 2.19e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 7.56e-01 8.65e-01 0.13700 4.93e-02 1.28e-01 7.77e-01 4.62e-01
Post-chaperonin tubulin folding pathway 22 6.00e-01 7.61e-01 0.13700 9.40e-02 9.93e-02 4.45e-01 4.20e-01
PLC beta mediated events 48 2.51e-01 4.29e-01 0.13700 -1.37e-01 -4.14e-03 1.02e-01 9.60e-01
Cytokine Signaling in Immune system 732 7.45e-08 7.69e-07 0.13700 9.30e-02 1.00e-01 1.83e-05 4.06e-06
Regulation of Expression and Function of Type II Classical Cadherins 32 4.15e-01 6.02e-01 0.13600 -1.35e-01 -1.77e-02 1.86e-01 8.62e-01
Regulation of Homotypic Cell-Cell Adhesion 32 4.15e-01 6.02e-01 0.13600 -1.35e-01 -1.77e-02 1.86e-01 8.62e-01
Presynaptic nicotinic acetylcholine receptors 12 7.40e-01 8.55e-01 0.13600 4.68e-02 1.28e-01 7.79e-01 4.43e-01
FGFR4 ligand binding and activation 13 7.34e-01 8.52e-01 0.13600 1.19e-01 6.43e-02 4.56e-01 6.88e-01
Interleukin-4 and Interleukin-13 signaling 103 9.34e-02 2.09e-01 0.13500 1.11e-01 7.80e-02 5.23e-02 1.71e-01
Interleukin-35 Signalling 12 7.14e-01 8.40e-01 0.13500 -6.80e-03 -1.35e-01 9.67e-01 4.18e-01
Cytoprotection by HMOX1 54 2.43e-01 4.20e-01 0.13500 2.79e-02 1.32e-01 7.23e-01 9.27e-02
Regulation of lipid metabolism by PPARalpha 115 3.23e-02 9.06e-02 0.13500 -1.67e-02 1.34e-01 7.57e-01 1.31e-02
Endogenous sterols 26 5.01e-01 6.78e-01 0.13500 -1.33e-01 -2.21e-02 2.40e-01 8.46e-01
Intraflagellar transport 51 2.63e-01 4.43e-01 0.13500 1.32e-01 2.57e-02 1.02e-01 7.51e-01
Regulation of CDH11 Expression and Function 29 4.29e-01 6.15e-01 0.13400 -1.34e-01 1.01e-02 2.11e-01 9.25e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 20 5.93e-01 7.56e-01 0.13400 -2.51e-02 -1.32e-01 8.46e-01 3.07e-01
Plasma lipoprotein clearance 37 4.18e-01 6.04e-01 0.13400 5.94e-02 1.20e-01 5.32e-01 2.05e-01
ER to Golgi Anterograde Transport 152 2.81e-02 8.03e-02 0.13400 5.71e-02 1.21e-01 2.24e-01 9.86e-03
Platelet calcium homeostasis 27 4.08e-01 5.97e-01 0.13400 -1.14e-01 7.01e-02 3.06e-01 5.29e-01
RA biosynthesis pathway 22 4.81e-01 6.60e-01 0.13400 -7.43e-02 1.11e-01 5.46e-01 3.68e-01
Synthesis of PIPs at the Golgi membrane 17 5.83e-01 7.46e-01 0.13300 -1.25e-01 4.75e-02 3.73e-01 7.35e-01
Repression of WNT target genes 14 6.53e-01 7.98e-01 0.13300 3.14e-02 -1.29e-01 8.39e-01 4.02e-01
Signaling by NOTCH1 69 1.96e-01 3.58e-01 0.13300 5.03e-02 1.23e-01 4.70e-01 7.69e-02
PPARA activates gene expression 113 3.59e-02 9.92e-02 0.13300 -2.37e-02 1.30e-01 6.63e-01 1.66e-02
Heme biosynthesis 13 6.69e-01 8.06e-01 0.13200 4.21e-02 -1.26e-01 7.93e-01 4.33e-01
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 15 6.96e-01 8.27e-01 0.13200 3.89e-02 1.26e-01 7.94e-01 3.97e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 117 7.76e-02 1.82e-01 0.13200 -7.68e-02 -1.07e-01 1.51e-01 4.48e-02
PIP3 activates AKT signaling 282 1.08e-03 4.94e-03 0.13200 3.29e-02 1.28e-01 3.42e-01 2.22e-04
Mucopolysaccharidoses 10 7.59e-01 8.66e-01 0.13200 -1.32e-01 4.49e-03 4.71e-01 9.80e-01
Signaling by KIT in disease 20 6.23e-01 7.78e-01 0.13100 3.91e-02 1.25e-01 7.62e-01 3.34e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 6.23e-01 7.78e-01 0.13100 3.91e-02 1.25e-01 7.62e-01 3.34e-01
RAC2 GTPase cycle 82 8.41e-02 1.93e-01 0.13100 -1.23e-01 4.45e-02 5.45e-02 4.86e-01
Golgi Associated Vesicle Biogenesis 51 2.22e-01 3.92e-01 0.13100 -3.51e-02 1.26e-01 6.65e-01 1.20e-01
Post-translational modification: synthesis of GPI-anchored proteins 91 7.25e-02 1.72e-01 0.13000 2.79e-02 -1.27e-01 6.46e-01 3.57e-02
Signaling by Nuclear Receptors 260 2.69e-03 1.06e-02 0.13000 4.42e-02 1.22e-01 2.20e-01 6.77e-04
Retrograde transport at the Trans-Golgi-Network 47 3.75e-01 5.62e-01 0.13000 8.80e-02 9.53e-02 2.96e-01 2.58e-01
Neurotransmitter release cycle 48 2.63e-01 4.43e-01 0.12900 1.28e-01 -1.95e-02 1.25e-01 8.15e-01
Post-translational protein modification 1359 7.66e-13 2.27e-11 0.12900 5.63e-02 1.16e-01 4.93e-04 6.71e-13
Acyl chain remodelling of PS 22 5.37e-01 7.03e-01 0.12800 3.06e-02 -1.25e-01 8.04e-01 3.11e-01
GPVI-mediated activation cascade 34 3.72e-01 5.61e-01 0.12800 -4.21e-02 1.21e-01 6.71e-01 2.21e-01
G-protein mediated events 53 2.49e-01 4.27e-01 0.12800 -1.28e-01 6.62e-03 1.07e-01 9.34e-01
SHC1 events in ERBB4 signaling 14 7.13e-01 8.40e-01 0.12700 1.59e-02 1.26e-01 9.18e-01 4.13e-01
PCNA-Dependent Long Patch Base Excision Repair 21 6.27e-01 7.81e-01 0.12700 3.92e-02 1.21e-01 7.56e-01 3.37e-01
G-protein beta:gamma signalling 30 4.00e-01 5.87e-01 0.12700 -9.22e-02 8.75e-02 3.82e-01 4.07e-01
Arachidonic acid metabolism 57 3.06e-01 4.89e-01 0.12700 1.12e-01 5.88e-02 1.43e-01 4.42e-01
MAPK3 (ERK1) activation 10 7.50e-01 8.61e-01 0.12600 1.15e-01 -5.15e-02 5.28e-01 7.78e-01
Prolactin receptor signaling 15 7.22e-01 8.45e-01 0.12600 3.84e-02 1.19e-01 7.97e-01 4.23e-01
Signaling by TGFBR3 48 2.94e-01 4.74e-01 0.12500 -1.25e-01 1.23e-02 1.35e-01 8.83e-01
Organelle biogenesis and maintenance 277 4.09e-03 1.52e-02 0.12500 6.20e-02 1.08e-01 7.55e-02 1.88e-03
RHO GTPases activate PAKs 19 6.96e-01 8.27e-01 0.12400 -8.98e-02 -8.53e-02 4.98e-01 5.20e-01
Signaling by FGFR3 in disease 21 6.70e-01 8.06e-01 0.12400 7.64e-02 9.71e-02 5.45e-01 4.41e-01
Axon guidance 523 2.92e-05 1.80e-04 0.12300 1.15e-01 4.56e-02 7.30e-06 7.41e-02
Signaling by Retinoic Acid 41 3.13e-01 5.00e-01 0.12300 -6.99e-02 1.01e-01 4.38e-01 2.61e-01
Loss of Nlp from mitotic centrosomes 66 2.64e-01 4.43e-01 0.12300 4.70e-02 1.14e-01 5.09e-01 1.10e-01
Loss of proteins required for interphase microtubule organization from the centrosome 66 2.64e-01 4.43e-01 0.12300 4.70e-02 1.14e-01 5.09e-01 1.10e-01
MAPK1/MAPK3 signaling 271 6.19e-03 2.22e-02 0.12300 9.91e-02 7.27e-02 4.98e-03 3.94e-02
C-type lectin receptors (CLRs) 138 7.28e-02 1.73e-01 0.12300 6.75e-02 1.02e-01 1.71e-01 3.76e-02
RAF/MAP kinase cascade 265 7.25e-03 2.54e-02 0.12200 9.79e-02 7.35e-02 6.07e-03 3.93e-02
Tandem pore domain potassium channels 12 7.87e-01 8.84e-01 0.12200 -1.12e-01 -4.82e-02 5.00e-01 7.72e-01
Activation of BH3-only proteins 30 4.36e-01 6.20e-01 0.12200 -6.32e-02 1.05e-01 5.49e-01 3.21e-01
Neurotoxicity of clostridium toxins 10 8.28e-01 9.02e-01 0.12200 -6.99e-02 -1.00e-01 7.02e-01 5.83e-01
Innate Immune System 1011 1.27e-09 2.18e-08 0.12200 2.77e-02 1.19e-01 1.36e-01 1.57e-10
NCAM signaling for neurite out-growth 62 2.16e-01 3.85e-01 0.12200 2.05e-02 -1.20e-01 7.80e-01 1.02e-01
Iron uptake and transport 56 3.49e-01 5.42e-01 0.12200 1.03e-01 6.45e-02 1.82e-01 4.04e-01
G beta:gamma signalling through BTK 17 6.67e-01 8.06e-01 0.12100 -9.32e-03 1.21e-01 9.47e-01 3.87e-01
Dermatan sulfate biosynthesis 10 7.59e-01 8.66e-01 0.12100 -9.77e-02 7.19e-02 5.93e-01 6.94e-01
Glycosphingolipid metabolism 52 3.86e-01 5.74e-01 0.12100 7.65e-02 9.41e-02 3.40e-01 2.41e-01
Signaling by Hippo 19 6.97e-01 8.27e-01 0.12100 -1.07e-01 -5.73e-02 4.20e-01 6.65e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 18 6.71e-01 8.07e-01 0.12100 1.21e-01 1.06e-02 3.76e-01 9.38e-01
Signaling by NTRK2 (TRKB) 25 6.28e-01 7.81e-01 0.12100 6.65e-02 1.01e-01 5.65e-01 3.81e-01
Phenylalanine and tyrosine metabolism 11 7.92e-01 8.87e-01 0.12100 2.17e-02 1.19e-01 9.01e-01 4.95e-01
Signaling by Erythropoietin 25 6.25e-01 7.80e-01 0.12100 5.96e-02 1.05e-01 6.06e-01 3.63e-01
Downstream signal transduction 29 5.11e-01 6.86e-01 0.12100 -4.19e-03 1.21e-01 9.69e-01 2.61e-01
G beta:gamma signalling through CDC42 19 6.28e-01 7.81e-01 0.12100 -2.21e-02 1.19e-01 8.68e-01 3.71e-01
Signaling by Interleukins 436 4.45e-04 2.27e-03 0.12100 8.61e-02 8.43e-02 2.04e-03 2.53e-03
Signaling by VEGF 103 6.27e-02 1.54e-01 0.12000 -1.00e-01 6.68e-02 7.96e-02 2.41e-01
Signaling by EGFR 52 3.67e-01 5.59e-01 0.12000 4.55e-02 1.11e-01 5.70e-01 1.65e-01
Rab regulation of trafficking 113 7.33e-02 1.73e-01 0.12000 -8.65e-03 1.20e-01 8.74e-01 2.79e-02
Nuclear signaling by ERBB4 32 4.36e-01 6.20e-01 0.12000 4.96e-02 -1.09e-01 6.27e-01 2.86e-01
Acyl chain remodelling of PE 29 4.60e-01 6.43e-01 0.11900 7.16e-02 -9.57e-02 5.05e-01 3.73e-01
Signaling by ERBB2 ECD mutants 16 7.47e-01 8.59e-01 0.11900 6.08e-02 1.03e-01 6.74e-01 4.77e-01
Signal transduction by L1 20 6.74e-01 8.09e-01 0.11900 1.14e-01 3.33e-02 3.77e-01 7.97e-01
Dissolution of Fibrin Clot 13 7.93e-01 8.87e-01 0.11800 1.00e-01 6.22e-02 5.30e-01 6.98e-01
Translation of Structural Proteins 9694635 55 3.59e-01 5.53e-01 0.11800 4.49e-02 1.09e-01 5.65e-01 1.61e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 103 8.85e-02 2.00e-01 0.11800 2.43e-02 -1.15e-01 6.70e-01 4.28e-02
Netrin-1 signaling 42 4.83e-01 6.60e-01 0.11800 -7.64e-02 -8.99e-02 3.91e-01 3.14e-01
Gap junction assembly 35 4.21e-01 6.07e-01 0.11700 1.09e-01 -4.43e-02 2.65e-01 6.50e-01
Removal of the Flap Intermediate from the C-strand 17 6.42e-01 7.92e-01 0.11700 -8.44e-02 8.16e-02 5.47e-01 5.60e-01
Adherens junctions interactions 58 3.70e-01 5.60e-01 0.11700 -7.57e-02 -8.97e-02 3.19e-01 2.38e-01
Response to metal ions 14 7.36e-01 8.53e-01 0.11700 1.17e-01 -4.96e-03 4.48e-01 9.74e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 29 4.73e-01 6.57e-01 0.11700 7.27e-02 -9.20e-02 4.98e-01 3.91e-01
Effects of PIP2 hydrolysis 26 6.42e-01 7.92e-01 0.11700 -7.82e-02 -8.73e-02 4.90e-01 4.41e-01
Regulation of actin dynamics for phagocytic cup formation 59 3.58e-01 5.53e-01 0.11700 9.82e-02 6.39e-02 1.92e-01 3.96e-01
Nervous system development 547 4.64e-05 2.77e-04 0.11700 1.10e-01 3.93e-02 1.00e-05 1.16e-01
Reversible hydration of carbon dioxide 11 8.19e-01 8.96e-01 0.11700 4.73e-02 1.07e-01 7.86e-01 5.38e-01
Synthesis of PIPs at the early endosome membrane 15 7.30e-01 8.49e-01 0.11700 -1.17e-01 -6.12e-03 4.33e-01 9.67e-01
Translation of Structural Proteins 9683701 29 6.03e-01 7.63e-01 0.11700 9.99e-02 6.05e-02 3.52e-01 5.73e-01
PKMTs methylate histone lysines 42 3.69e-01 5.60e-01 0.11700 -3.28e-02 1.12e-01 7.13e-01 2.09e-01
NPAS4 regulates expression of target genes 20 6.49e-01 7.96e-01 0.11700 1.16e-01 -4.32e-03 3.67e-01 9.73e-01
RHOH GTPase cycle 36 3.98e-01 5.86e-01 0.11700 -7.55e-02 8.88e-02 4.33e-01 3.57e-01
PECAM1 interactions 12 8.02e-01 8.92e-01 0.11600 1.10e-01 3.66e-02 5.10e-01 8.26e-01
Pyrimidine catabolism 12 7.42e-01 8.58e-01 0.11600 -5.90e-02 9.96e-02 7.23e-01 5.50e-01
Interleukin-37 signaling 21 6.22e-01 7.78e-01 0.11600 -1.13e-01 2.26e-02 3.68e-01 8.58e-01
Signaling by high-kinase activity BRAF mutants 34 5.12e-01 6.86e-01 0.11600 1.68e-02 1.14e-01 8.65e-01 2.48e-01
Signaling by NTRK3 (TRKC) 17 7.55e-01 8.64e-01 0.11500 7.79e-02 8.52e-02 5.78e-01 5.43e-01
Signaling by ERBB2 TMD/JMD mutants 22 6.96e-01 8.27e-01 0.11500 8.37e-02 7.92e-02 4.97e-01 5.20e-01
Interleukin-27 signaling 11 7.73e-01 8.73e-01 0.11500 3.80e-02 -1.09e-01 8.27e-01 5.32e-01
Protein folding 95 2.02e-01 3.65e-01 0.11500 6.02e-02 9.81e-02 3.10e-01 9.84e-02
Sulfur amino acid metabolism 27 6.15e-01 7.75e-01 0.11500 3.87e-02 1.08e-01 7.28e-01 3.30e-01
Intracellular signaling by second messengers 321 2.47e-03 9.83e-03 0.11500 2.32e-02 1.12e-01 4.75e-01 5.30e-04
Cell-Cell communication 148 7.86e-02 1.84e-01 0.11500 -4.99e-02 -1.03e-01 2.94e-01 2.99e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 70 2.25e-01 3.96e-01 0.11500 -1.08e-02 1.14e-01 8.76e-01 9.87e-02
Norepinephrine Neurotransmitter Release Cycle 17 7.50e-01 8.61e-01 0.11500 -5.50e-02 -1.00e-01 6.95e-01 4.73e-01
Mitochondrial calcium ion transport 21 6.44e-01 7.93e-01 0.11400 -6.87e-03 1.14e-01 9.57e-01 3.65e-01
Recruitment of NuMA to mitotic centrosomes 90 2.21e-01 3.91e-01 0.11400 5.58e-02 9.96e-02 3.60e-01 1.02e-01
Cell junction organization 113 1.41e-01 2.81e-01 0.11400 -4.34e-02 -1.05e-01 4.26e-01 5.28e-02
FOXO-mediated transcription 65 2.90e-01 4.68e-01 0.11400 1.13e-01 1.74e-02 1.16e-01 8.08e-01
Attachment and Entry 9694614 16 6.99e-01 8.29e-01 0.11400 -1.10e-01 3.05e-02 4.48e-01 8.33e-01
RND1 GTPase cycle 41 4.19e-01 6.05e-01 0.11400 -1.13e-01 1.35e-02 2.11e-01 8.81e-01
Regulation of signaling by CBL 22 7.01e-01 8.29e-01 0.11400 9.09e-02 6.81e-02 4.61e-01 5.80e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 21 6.45e-01 7.94e-01 0.11300 1.01e-02 -1.13e-01 9.36e-01 3.70e-01
Glycosphingolipid biosynthesis 19 6.57e-01 8.00e-01 0.11300 1.10e-01 -2.80e-02 4.07e-01 8.33e-01
Formation of the ureteric bud 21 6.77e-01 8.11e-01 0.11300 2.10e-02 1.11e-01 8.68e-01 3.77e-01
MAPK family signaling cascades 312 7.15e-03 2.51e-02 0.11300 8.96e-02 6.92e-02 6.50e-03 3.55e-02
Regulation of pyruvate dehydrogenase (PDH) complex 13 8.08e-01 8.96e-01 0.11300 5.76e-02 9.74e-02 7.19e-01 5.43e-01
Complement cascade 56 4.09e-01 5.97e-01 0.11300 -7.17e-02 -8.75e-02 3.53e-01 2.57e-01
Biotin transport and metabolism 10 7.96e-01 8.89e-01 0.11300 -4.02e-02 1.06e-01 8.26e-01 5.63e-01
Protein-protein interactions at synapses 78 2.81e-01 4.57e-01 0.11300 -5.91e-02 -9.64e-02 3.67e-01 1.41e-01
Intrinsic Pathway for Apoptosis 53 4.32e-01 6.18e-01 0.11300 8.22e-02 7.76e-02 3.01e-01 3.28e-01
Signaling by PDGFRA extracellular domain mutants 12 7.52e-01 8.62e-01 0.11300 -6.45e-02 9.24e-02 6.99e-01 5.79e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 7.52e-01 8.62e-01 0.11300 -6.45e-02 9.24e-02 6.99e-01 5.79e-01
Nicotinamide salvaging 19 6.60e-01 8.02e-01 0.11200 1.07e-01 -3.34e-02 4.21e-01 8.01e-01
RAF activation 32 4.80e-01 6.60e-01 0.11200 -5.40e-02 9.77e-02 5.97e-01 3.39e-01
VxPx cargo-targeting to cilium 20 7.26e-01 8.46e-01 0.11100 -5.37e-02 -9.76e-02 6.78e-01 4.50e-01
Cell surface interactions at the vascular wall 130 4.89e-02 1.28e-01 0.11100 -7.37e-02 8.33e-02 1.47e-01 1.01e-01
EPHA-mediated growth cone collapse 29 5.97e-01 7.59e-01 0.11100 -1.09e-01 -2.08e-02 3.09e-01 8.46e-01
Formation of WDR5-containing histone-modifying complexes 38 5.17e-01 6.90e-01 0.11100 2.72e-02 1.08e-01 7.72e-01 2.51e-01
Acetylcholine Neurotransmitter Release Cycle 17 6.82e-01 8.16e-01 0.11100 5.22e-02 -9.76e-02 7.09e-01 4.86e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 7.95e-01 8.88e-01 0.11100 6.60e-02 -8.86e-02 7.18e-01 6.27e-01
Peptide hormone metabolism 81 1.76e-01 3.32e-01 0.11000 -1.05e-01 3.52e-02 1.03e-01 5.84e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 38 5.27e-01 6.96e-01 0.11000 3.23e-02 1.06e-01 7.31e-01 2.60e-01
PI-3K cascade:FGFR2 22 6.69e-01 8.06e-01 0.11000 1.10e-01 1.03e-02 3.73e-01 9.33e-01
Metabolic disorders of biological oxidation enzymes 33 5.31e-01 6.99e-01 0.11000 3.21e-03 -1.10e-01 9.75e-01 2.74e-01
Processive synthesis on the C-strand of the telomere 19 6.48e-01 7.95e-01 0.11000 -7.72e-02 7.83e-02 5.60e-01 5.54e-01
Stimuli-sensing channels 101 2.18e-01 3.88e-01 0.11000 -6.68e-02 -8.72e-02 2.46e-01 1.30e-01
CD28 co-stimulation 32 4.85e-01 6.62e-01 0.11000 -8.53e-02 6.88e-02 4.04e-01 5.00e-01
Chaperonin-mediated protein folding 89 2.64e-01 4.43e-01 0.10900 6.52e-02 8.78e-02 2.87e-01 1.52e-01
Cardiac conduction 125 1.14e-01 2.39e-01 0.10900 -1.74e-02 -1.08e-01 7.37e-01 3.73e-02
Regulation of MECP2 expression and activity 30 5.19e-01 6.92e-01 0.10900 -9.65e-02 5.10e-02 3.60e-01 6.29e-01
Keratan sulfate degradation 15 8.02e-01 8.92e-01 0.10900 -6.97e-02 -8.32e-02 6.40e-01 5.77e-01
Other semaphorin interactions 18 7.38e-01 8.55e-01 0.10800 -1.06e-01 -2.09e-02 4.36e-01 8.78e-01
Gap junction trafficking 46 3.88e-01 5.76e-01 0.10800 1.01e-01 -3.64e-02 2.34e-01 6.69e-01
Signaling by ERBB2 in Cancer 26 6.68e-01 8.06e-01 0.10700 1.00e-01 3.94e-02 3.78e-01 7.28e-01
RND3 GTPase cycle 41 4.92e-01 6.69e-01 0.10700 -1.07e-01 -1.07e-02 2.37e-01 9.06e-01
Chondroitin sulfate/dermatan sulfate metabolism 45 4.06e-01 5.94e-01 0.10700 -3.01e-02 1.03e-01 7.27e-01 2.32e-01
NRAGE signals death through JNK 53 4.60e-01 6.43e-01 0.10700 -9.14e-02 -5.61e-02 2.50e-01 4.80e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 128 7.11e-02 1.70e-01 0.10700 9.82e-02 -4.31e-02 5.51e-02 3.99e-01
Regulation of Complement cascade 45 5.26e-01 6.96e-01 0.10700 -7.88e-02 -7.27e-02 3.61e-01 3.99e-01
GPER1 signaling 45 3.85e-01 5.74e-01 0.10700 -5.41e-02 9.25e-02 5.30e-01 2.83e-01
Ion transport by P-type ATPases 51 3.64e-01 5.58e-01 0.10600 3.17e-02 -1.02e-01 6.95e-01 2.10e-01
COPI-mediated anterograde transport 100 2.37e-01 4.13e-01 0.10600 9.08e-02 5.54e-02 1.17e-01 3.38e-01
Regulation of NPAS4 gene expression 13 8.23e-01 8.99e-01 0.10600 -9.77e-02 -4.10e-02 5.42e-01 7.98e-01
Acetylcholine binding and downstream events 14 8.18e-01 8.96e-01 0.10600 9.23e-02 5.11e-02 5.50e-01 7.41e-01
Postsynaptic nicotinic acetylcholine receptors 14 8.18e-01 8.96e-01 0.10600 9.23e-02 5.11e-02 5.50e-01 7.41e-01
Centrosome maturation 78 3.24e-01 5.12e-01 0.10500 4.67e-02 9.43e-02 4.76e-01 1.50e-01
Recruitment of mitotic centrosome proteins and complexes 78 3.24e-01 5.12e-01 0.10500 4.67e-02 9.43e-02 4.76e-01 1.50e-01
Uptake and actions of bacterial toxins 28 5.84e-01 7.46e-01 0.10500 -1.01e-01 2.87e-02 3.54e-01 7.93e-01
Role of phospholipids in phagocytosis 25 7.07e-01 8.34e-01 0.10500 -6.03e-02 -8.59e-02 6.02e-01 4.57e-01
Immune System 1934 3.80e-12 1.03e-10 0.10500 3.68e-02 9.81e-02 7.34e-03 8.84e-13
Cargo recognition for clathrin-mediated endocytosis 100 1.95e-01 3.57e-01 0.10500 1.15e-02 1.04e-01 8.42e-01 7.18e-02
SLBP independent Processing of Histone Pre-mRNAs 10 8.57e-01 9.18e-01 0.10400 2.48e-02 1.01e-01 8.92e-01 5.79e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 12 8.29e-01 9.02e-01 0.10400 -1.98e-02 -1.02e-01 9.06e-01 5.41e-01
Transport to the Golgi and subsequent modification 183 6.38e-02 1.56e-01 0.10300 2.48e-02 1.00e-01 5.63e-01 1.91e-02
G alpha (i) signalling events 307 1.81e-02 5.57e-02 0.10300 -8.06e-02 -6.40e-02 1.51e-02 5.39e-02
Synaptic adhesion-like molecules 19 7.70e-01 8.72e-01 0.10300 9.12e-02 4.72e-02 4.91e-01 7.21e-01
ADORA2B mediated anti-inflammatory cytokines production 42 4.37e-01 6.20e-01 0.10300 -5.86e-02 8.43e-02 5.11e-01 3.44e-01
Signaling by Non-Receptor Tyrosine Kinases 54 3.74e-01 5.62e-01 0.10200 -2.85e-02 9.84e-02 7.18e-01 2.11e-01
Signaling by PTK6 54 3.74e-01 5.62e-01 0.10200 -2.85e-02 9.84e-02 7.18e-01 2.11e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 5.41e-01 7.07e-01 0.10200 3.98e-02 9.43e-02 6.48e-01 2.79e-01
Adaptive Immune System 735 8.06e-05 4.52e-04 0.10200 5.71e-02 8.49e-02 8.40e-03 8.78e-05
Factors involved in megakaryocyte development and platelet production 148 5.51e-02 1.41e-01 0.10200 -7.80e-02 6.60e-02 1.01e-01 1.66e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 7.81e-01 8.79e-01 0.10200 -2.85e-02 -9.81e-02 8.39e-01 4.84e-01
LDL clearance 19 7.71e-01 8.72e-01 0.10200 9.26e-02 4.27e-02 4.85e-01 7.47e-01
Sphingolipid de novo biosynthesis 37 4.86e-01 6.63e-01 0.10200 -5.98e-02 8.26e-02 5.29e-01 3.85e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 4.81e-01 6.60e-01 0.10200 1.99e-02 9.99e-02 8.10e-01 2.26e-01
Basigin interactions 24 6.51e-01 7.96e-01 0.10100 -2.87e-02 9.73e-02 8.08e-01 4.09e-01
Ephrin signaling 17 8.02e-01 8.92e-01 0.10100 -8.52e-02 -5.46e-02 5.43e-01 6.97e-01
Signaling by ERBB4 57 4.62e-01 6.44e-01 0.10100 9.29e-02 3.99e-02 2.25e-01 6.03e-01
APC truncation mutants have impaired AXIN binding 13 8.18e-01 8.96e-01 0.10100 7.65e-03 1.01e-01 9.62e-01 5.29e-01
AXIN missense mutants destabilize the destruction complex 13 8.18e-01 8.96e-01 0.10100 7.65e-03 1.01e-01 9.62e-01 5.29e-01
Signaling by AMER1 mutants 13 8.18e-01 8.96e-01 0.10100 7.65e-03 1.01e-01 9.62e-01 5.29e-01
Signaling by APC mutants 13 8.18e-01 8.96e-01 0.10100 7.65e-03 1.01e-01 9.62e-01 5.29e-01
Signaling by AXIN mutants 13 8.18e-01 8.96e-01 0.10100 7.65e-03 1.01e-01 9.62e-01 5.29e-01
Truncations of AMER1 destabilize the destruction complex 13 8.18e-01 8.96e-01 0.10100 7.65e-03 1.01e-01 9.62e-01 5.29e-01
Membrane Trafficking 607 9.15e-05 5.09e-04 0.10100 3.11e-03 1.01e-01 8.96e-01 2.20e-05
PI-3K cascade:FGFR4 19 7.51e-01 8.62e-01 0.10100 9.99e-02 1.32e-02 4.51e-01 9.21e-01
Metabolism of folate and pterines 17 7.62e-01 8.68e-01 0.10100 -2.44e-03 1.01e-01 9.86e-01 4.73e-01
RAC1 GTPase cycle 172 5.88e-02 1.48e-01 0.10000 -9.96e-02 1.26e-02 2.43e-02 7.76e-01
MHC class II antigen presentation 121 2.13e-01 3.81e-01 0.10000 5.11e-02 8.62e-02 3.32e-01 1.02e-01
Formation of annular gap junctions 11 8.63e-01 9.20e-01 0.10000 9.26e-02 3.80e-02 5.95e-01 8.27e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 45 5.67e-01 7.30e-01 0.09940 5.15e-02 8.51e-02 5.50e-01 3.23e-01
CaMK IV-mediated phosphorylation of CREB 10 8.41e-01 9.10e-01 0.09920 9.43e-02 -3.07e-02 6.06e-01 8.67e-01
Azathioprine ADME 22 7.16e-01 8.40e-01 0.09900 2.21e-03 9.90e-02 9.86e-01 4.22e-01
Signaling by ERBB2 50 5.21e-01 6.93e-01 0.09870 3.68e-02 9.16e-02 6.53e-01 2.63e-01
Metallothioneins bind metals 11 8.21e-01 8.98e-01 0.09850 8.59e-02 -4.81e-02 6.22e-01 7.82e-01
HS-GAG biosynthesis 28 7.11e-01 8.39e-01 0.09800 -8.16e-02 -5.43e-02 4.55e-01 6.19e-01
Glycogen metabolism 22 7.40e-01 8.56e-01 0.09800 2.19e-02 9.55e-02 8.59e-01 4.38e-01
GPCR downstream signalling 606 8.37e-04 3.98e-03 0.09760 -7.96e-02 -5.65e-02 8.13e-04 1.75e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29 7.10e-01 8.38e-01 0.09760 7.10e-02 6.69e-02 5.08e-01 5.33e-01
Muscle contraction 196 6.17e-02 1.53e-01 0.09740 -8.52e-03 -9.71e-02 8.37e-01 1.91e-02
ERBB2 Regulates Cell Motility 15 7.65e-01 8.69e-01 0.09730 6.80e-02 -6.95e-02 6.48e-01 6.41e-01
Metabolism 2078 1.28e-10 2.75e-09 0.09690 4.84e-02 8.40e-02 2.75e-04 2.69e-10
Long-term potentiation 22 7.00e-01 8.29e-01 0.09670 2.62e-02 -9.31e-02 8.31e-01 4.50e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 42 4.87e-01 6.64e-01 0.09670 -4.46e-02 8.58e-02 6.17e-01 3.36e-01
FCERI mediated Ca+2 mobilization 30 6.79e-01 8.14e-01 0.09660 -9.22e-02 -2.89e-02 3.82e-01 7.84e-01
IL-6-type cytokine receptor ligand interactions 17 7.78e-01 8.78e-01 0.09610 5.04e-03 -9.59e-02 9.71e-01 4.93e-01
Signaling by MET 78 3.32e-01 5.23e-01 0.09580 -9.58e-02 -3.56e-03 1.44e-01 9.57e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 8.42e-01 9.10e-01 0.09580 -9.58e-02 -4.42e-04 5.66e-01 9.98e-01
RAC3 GTPase cycle 86 2.42e-01 4.18e-01 0.09550 -8.66e-02 4.02e-02 1.65e-01 5.19e-01
Synthesis, secretion, and deacylation of Ghrelin 19 8.08e-01 8.96e-01 0.09490 6.59e-02 6.83e-02 6.19e-01 6.06e-01
Sema3A PAK dependent Axon repulsion 14 8.16e-01 8.96e-01 0.09490 -9.47e-02 6.53e-03 5.40e-01 9.66e-01
Adenylate cyclase activating pathway 10 8.54e-01 9.17e-01 0.09480 2.89e-02 -9.03e-02 8.74e-01 6.21e-01
Recycling pathway of L1 42 5.58e-01 7.21e-01 0.09420 6.43e-06 9.42e-02 1.00e+00 2.91e-01
DARPP-32 events 24 7.63e-01 8.68e-01 0.09320 4.41e-02 8.21e-02 7.08e-01 4.86e-01
Interleukin-7 signaling 21 7.48e-01 8.60e-01 0.09280 9.27e-02 -5.82e-03 4.62e-01 9.63e-01
Ca2+ pathway 62 5.17e-01 6.90e-01 0.09270 -6.87e-02 -6.22e-02 3.49e-01 3.97e-01
Carboxyterminal post-translational modifications of tubulin 43 5.41e-01 7.07e-01 0.09180 8.98e-02 -1.90e-02 3.08e-01 8.29e-01
VEGFR2 mediated cell proliferation 19 7.46e-01 8.59e-01 0.09160 -8.04e-02 4.39e-02 5.44e-01 7.40e-01
Activation of the AP-1 family of transcription factors 10 8.61e-01 9.19e-01 0.09150 8.50e-02 -3.41e-02 6.42e-01 8.52e-01
Keratan sulfate/keratin metabolism 36 6.29e-01 7.81e-01 0.09140 -9.14e-02 -2.88e-03 3.43e-01 9.76e-01
Prolonged ERK activation events 14 8.61e-01 9.19e-01 0.09140 -7.91e-02 -4.58e-02 6.08e-01 7.67e-01
FCGR3A-mediated phagocytosis 57 5.42e-01 7.07e-01 0.09120 8.01e-02 4.37e-02 2.96e-01 5.68e-01
Leishmania phagocytosis 57 5.42e-01 7.07e-01 0.09120 8.01e-02 4.37e-02 2.96e-01 5.68e-01
Parasite infection 57 5.42e-01 7.07e-01 0.09120 8.01e-02 4.37e-02 2.96e-01 5.68e-01
G beta:gamma signalling through PLC beta 20 7.31e-01 8.49e-01 0.09110 -6.81e-02 6.04e-02 5.98e-01 6.40e-01
RHOC GTPase cycle 70 3.71e-01 5.61e-01 0.09090 -8.83e-02 2.17e-02 2.02e-01 7.54e-01
Sema4D in semaphorin signaling 24 7.03e-01 8.31e-01 0.09080 -3.25e-02 8.47e-02 7.83e-01 4.72e-01
A tetrasaccharide linker sequence is required for GAG synthesis 23 7.91e-01 8.86e-01 0.09040 -5.61e-02 -7.08e-02 6.41e-01 5.57e-01
Unblocking of NMDA receptors, glutamate binding and activation 19 7.61e-01 8.68e-01 0.09030 2.94e-02 -8.54e-02 8.25e-01 5.20e-01
Serotonin Neurotransmitter Release Cycle 17 8.40e-01 9.10e-01 0.09010 -5.08e-02 -7.44e-02 7.17e-01 5.95e-01
Nicotinate metabolism 31 7.18e-01 8.42e-01 0.08970 8.24e-02 3.55e-02 4.27e-01 7.32e-01
Phospholipid metabolism 200 5.52e-02 1.41e-01 0.08950 -8.06e-02 3.91e-02 4.95e-02 3.40e-01
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 17 7.86e-01 8.84e-01 0.08950 -3.00e-02 8.43e-02 8.31e-01 5.47e-01
Interleukin receptor SHC signaling 23 7.44e-01 8.58e-01 0.08940 -8.92e-02 6.10e-03 4.59e-01 9.60e-01
Phase I - Functionalization of compounds 103 2.37e-01 4.13e-01 0.08930 2.78e-02 -8.48e-02 6.26e-01 1.37e-01
Zinc transporters 15 8.58e-01 9.18e-01 0.08920 7.75e-02 4.41e-02 6.03e-01 7.68e-01
Signaling by SCF-KIT 43 5.27e-01 6.96e-01 0.08910 -5.38e-02 7.10e-02 5.41e-01 4.20e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 29 7.21e-01 8.44e-01 0.08900 8.67e-02 2.00e-02 4.19e-01 8.52e-01
Trafficking of AMPA receptors 29 7.21e-01 8.44e-01 0.08900 8.67e-02 2.00e-02 4.19e-01 8.52e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 8.24e-01 8.99e-01 0.08900 -8.52e-02 2.59e-02 5.81e-01 8.67e-01
CTNNB1 S33 mutants aren’t phosphorylated 14 8.18e-01 8.96e-01 0.08900 -3.73e-02 8.08e-02 8.09e-01 6.01e-01
CTNNB1 S37 mutants aren’t phosphorylated 14 8.18e-01 8.96e-01 0.08900 -3.73e-02 8.08e-02 8.09e-01 6.01e-01
CTNNB1 S45 mutants aren’t phosphorylated 14 8.18e-01 8.96e-01 0.08900 -3.73e-02 8.08e-02 8.09e-01 6.01e-01
CTNNB1 T41 mutants aren’t phosphorylated 14 8.18e-01 8.96e-01 0.08900 -3.73e-02 8.08e-02 8.09e-01 6.01e-01
Signaling by CTNNB1 phospho-site mutants 14 8.18e-01 8.96e-01 0.08900 -3.73e-02 8.08e-02 8.09e-01 6.01e-01
Signaling by GSK3beta mutants 14 8.18e-01 8.96e-01 0.08900 -3.73e-02 8.08e-02 8.09e-01 6.01e-01
Glyoxylate metabolism and glycine degradation 18 7.65e-01 8.69e-01 0.08880 -6.93e-02 5.56e-02 6.11e-01 6.83e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 8.64e-01 9.21e-01 0.08860 3.50e-02 8.14e-02 8.21e-01 5.98e-01
SHC1 events in ERBB2 signaling 22 8.08e-01 8.96e-01 0.08840 6.55e-02 5.94e-02 5.95e-01 6.30e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 27 7.56e-01 8.65e-01 0.08790 -3.26e-02 -8.17e-02 7.70e-01 4.63e-01
Clathrin-mediated endocytosis 139 2.03e-01 3.67e-01 0.08730 7.28e-03 8.70e-02 8.82e-01 7.64e-02
Gap junction trafficking and regulation 48 5.20e-01 6.92e-01 0.08690 7.93e-02 -3.55e-02 3.42e-01 6.70e-01
Listeria monocytogenes entry into host cells 19 8.23e-01 8.99e-01 0.08690 2.98e-02 8.16e-02 8.22e-01 5.38e-01
Transcriptional and post-translational regulation of MITF-M expression and activity 49 5.11e-01 6.86e-01 0.08680 -3.75e-02 7.83e-02 6.50e-01 3.43e-01
Heparan sulfate/heparin (HS-GAG) metabolism 52 6.16e-01 7.75e-01 0.08650 -6.60e-02 -5.59e-02 4.10e-01 4.85e-01
Bacterial Infection Pathways 67 5.16e-01 6.89e-01 0.08640 3.47e-02 7.91e-02 6.23e-01 2.63e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 42 6.68e-01 8.06e-01 0.08620 4.09e-02 7.59e-02 6.47e-01 3.95e-01
Signaling by RAS mutants 42 6.68e-01 8.06e-01 0.08620 4.09e-02 7.59e-02 6.47e-01 3.95e-01
Signaling by moderate kinase activity BRAF mutants 42 6.68e-01 8.06e-01 0.08620 4.09e-02 7.59e-02 6.47e-01 3.95e-01
Signaling downstream of RAS mutants 42 6.68e-01 8.06e-01 0.08620 4.09e-02 7.59e-02 6.47e-01 3.95e-01
PKA-mediated phosphorylation of CREB 19 7.69e-01 8.72e-01 0.08550 -6.44e-02 5.62e-02 6.27e-01 6.72e-01
MASTL Facilitates Mitotic Progression 10 8.76e-01 9.29e-01 0.08530 -3.61e-02 7.73e-02 8.43e-01 6.72e-01
CD28 dependent PI3K/Akt signaling 22 7.63e-01 8.68e-01 0.08520 -1.77e-02 8.33e-02 8.86e-01 4.99e-01
PKA activation in glucagon signalling 17 7.93e-01 8.87e-01 0.08510 -5.18e-02 6.75e-02 7.11e-01 6.30e-01
Ion channel transport 172 1.95e-01 3.58e-01 0.08460 -3.23e-02 -7.82e-02 4.65e-01 7.69e-02
Signaling by ERBB2 KD Mutants 25 7.88e-01 8.84e-01 0.08460 7.81e-02 3.25e-02 4.99e-01 7.79e-01
Removal of the Flap Intermediate 13 8.90e-01 9.32e-01 0.08450 4.86e-02 6.91e-02 7.62e-01 6.66e-01
Cytochrome P450 - arranged by substrate type 65 5.29e-01 6.98e-01 0.08380 -2.25e-02 -8.07e-02 7.54e-01 2.61e-01
Glycosaminoglycan metabolism 120 2.40e-01 4.16e-01 0.08360 -8.15e-02 1.86e-02 1.23e-01 7.25e-01
Signaling by BRAF and RAF1 fusions 63 4.49e-01 6.30e-01 0.08350 -3.75e-02 7.47e-02 6.07e-01 3.05e-01
Oncogenic MAPK signaling 78 3.89e-01 5.76e-01 0.08320 -2.53e-02 7.93e-02 6.99e-01 2.26e-01
Activation of BAD and translocation to mitochondria 15 8.30e-01 9.02e-01 0.08320 -7.68e-02 3.19e-02 6.06e-01 8.31e-01
Vesicle-mediated transport 645 9.31e-04 4.38e-03 0.08300 -6.45e-03 8.27e-02 7.80e-01 3.35e-04
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 644 1.96e-03 8.09e-03 0.08280 1.47e-02 8.15e-02 5.24e-01 4.16e-04
GAB1 signalosome 17 8.08e-01 8.96e-01 0.08260 -3.93e-02 7.27e-02 7.79e-01 6.04e-01
Deadenylation-dependent mRNA decay 53 5.99e-01 7.60e-01 0.08260 8.04e-02 1.91e-02 3.11e-01 8.09e-01
TGFBR3 PTM regulation 10 8.79e-01 9.31e-01 0.08240 5.80e-02 -5.85e-02 7.51e-01 7.49e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 8.50e-01 9.14e-01 0.08200 -4.34e-02 6.95e-02 7.86e-01 6.64e-01
Rap1 signalling 16 8.67e-01 9.23e-01 0.08190 3.28e-02 7.51e-02 8.20e-01 6.03e-01
Signaling by Activin 17 8.22e-01 8.98e-01 0.08150 2.26e-02 -7.84e-02 8.72e-01 5.76e-01
SLC transporter disorders 94 4.43e-01 6.25e-01 0.08090 3.26e-02 7.41e-02 5.85e-01 2.14e-01
Voltage gated Potassium channels 42 6.19e-01 7.77e-01 0.08090 -7.74e-02 2.35e-02 3.86e-01 7.92e-01
Defective B3GAT3 causes JDSSDHD 17 8.53e-01 9.17e-01 0.08090 -1.75e-02 -7.89e-02 9.01e-01 5.73e-01
Processive synthesis on the lagging strand 14 8.89e-01 9.32e-01 0.08000 3.51e-02 7.18e-02 8.20e-01 6.42e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 29 7.14e-01 8.40e-01 0.07990 -3.43e-02 7.22e-02 7.49e-01 5.01e-01
Aquaporin-mediated transport 51 6.35e-01 7.85e-01 0.07980 -7.69e-02 -2.11e-02 3.42e-01 7.94e-01
Signaling by Rho GTPases 630 3.50e-03 1.33e-02 0.07950 1.32e-02 7.84e-02 5.73e-01 7.79e-04
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 9.18e-01 9.48e-01 0.07920 2.57e-02 7.50e-02 8.88e-01 6.81e-01
Cargo trafficking to the periciliary membrane 49 6.50e-01 7.96e-01 0.07920 7.66e-02 2.03e-02 3.54e-01 8.06e-01
Integrin signaling 27 7.61e-01 8.68e-01 0.07900 -7.88e-02 6.46e-03 4.79e-01 9.54e-01
Glycogen breakdown (glycogenolysis) 11 9.18e-01 9.48e-01 0.07900 -5.47e-02 -5.70e-02 7.54e-01 7.44e-01
RHO GTPases activate CIT 19 8.00e-01 8.92e-01 0.07870 5.53e-02 -5.60e-02 6.76e-01 6.73e-01
The role of Nef in HIV-1 replication and disease pathogenesis 27 8.06e-01 8.96e-01 0.07830 6.95e-02 3.63e-02 5.32e-01 7.44e-01
Deadenylation of mRNA 22 8.46e-01 9.12e-01 0.07800 -5.03e-02 -5.97e-02 6.83e-01 6.28e-01
Platelet Aggregation (Plug Formation) 39 7.20e-01 8.44e-01 0.07800 -7.46e-02 -2.28e-02 4.20e-01 8.05e-01
RHOG GTPase cycle 71 5.04e-01 6.80e-01 0.07780 -7.77e-02 3.97e-03 2.58e-01 9.54e-01
Regulation of KIT signaling 16 8.86e-01 9.32e-01 0.07760 -6.40e-02 -4.39e-02 6.58e-01 7.61e-01
RHO GTPase cycle 420 9.94e-03 3.38e-02 0.07730 -6.32e-02 4.44e-02 2.62e-02 1.18e-01
Organic cation/anion/zwitterion transport 15 8.77e-01 9.29e-01 0.07650 -8.26e-03 -7.61e-02 9.56e-01 6.10e-01
Hemostasis 578 2.19e-03 8.87e-03 0.07640 -6.41e-02 4.15e-02 8.39e-03 8.83e-02
CLEC7A (Dectin-1) induces NFAT activation 11 9.04e-01 9.41e-01 0.07630 2.29e-04 -7.63e-02 9.99e-01 6.61e-01
Leishmania infection 157 2.70e-01 4.48e-01 0.07610 1.40e-02 7.48e-02 7.63e-01 1.06e-01
Parasitic Infection Pathways 157 2.70e-01 4.48e-01 0.07610 1.40e-02 7.48e-02 7.63e-01 1.06e-01
eNOS activation 10 9.19e-01 9.48e-01 0.07590 -7.51e-02 -1.09e-02 6.81e-01 9.52e-01
Platelet sensitization by LDL 17 8.45e-01 9.12e-01 0.07570 -1.90e-02 7.33e-02 8.92e-01 6.01e-01
CD209 (DC-SIGN) signaling 20 8.65e-01 9.21e-01 0.07560 -6.41e-02 -4.01e-02 6.20e-01 7.56e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 12 8.89e-01 9.32e-01 0.07520 1.95e-02 -7.26e-02 9.07e-01 6.63e-01
Defective EXT2 causes exostoses 2 12 8.89e-01 9.32e-01 0.07520 1.95e-02 -7.26e-02 9.07e-01 6.63e-01
Peptide ligand-binding receptors 190 1.37e-01 2.75e-01 0.07510 4.33e-02 -6.13e-02 3.03e-01 1.45e-01
GABA receptor activation 57 5.75e-01 7.38e-01 0.07490 -7.21e-02 2.03e-02 3.47e-01 7.91e-01
GPCR ligand binding 448 4.64e-02 1.23e-01 0.07460 -6.03e-02 -4.39e-02 2.87e-02 1.12e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 8.62e-01 9.20e-01 0.07450 -1.27e-02 7.34e-02 9.30e-01 6.11e-01
COPI-independent Golgi-to-ER retrograde traffic 51 6.21e-01 7.78e-01 0.07430 7.29e-02 -1.47e-02 3.68e-01 8.56e-01
Striated Muscle Contraction 35 7.86e-01 8.84e-01 0.07400 -4.46e-02 -5.91e-02 6.48e-01 5.45e-01
RHO GTPases Activate ROCKs 19 8.80e-01 9.31e-01 0.07350 -5.69e-02 -4.66e-02 6.68e-01 7.25e-01
SLC-mediated transmembrane transport 239 1.08e-01 2.32e-01 0.07330 2.15e-02 -7.01e-02 5.68e-01 6.20e-02
Mitochondrial Fatty Acid Beta-Oxidation 36 7.25e-01 8.46e-01 0.07300 -1.30e-02 7.18e-02 8.93e-01 4.56e-01
HS-GAG degradation 21 8.10e-01 8.96e-01 0.07290 5.65e-02 -4.61e-02 6.54e-01 7.14e-01
Diseases of glycosylation 139 3.57e-01 5.51e-01 0.07290 -7.04e-02 -1.87e-02 1.52e-01 7.04e-01
Phase II - Conjugation of compounds 106 5.02e-01 6.79e-01 0.07230 -4.57e-02 -5.60e-02 4.16e-01 3.19e-01
Signaling by GPCR 678 1.27e-02 4.09e-02 0.07230 -6.08e-02 -3.91e-02 6.94e-03 8.23e-02
Extra-nuclear estrogen signaling 74 5.11e-01 6.86e-01 0.07210 -2.12e-02 6.89e-02 7.52e-01 3.05e-01
Defective B4GALT7 causes EDS, progeroid type 17 8.95e-01 9.35e-01 0.07210 -5.78e-02 -4.32e-02 6.80e-01 7.58e-01
Phase 2 - plateau phase 14 9.01e-01 9.39e-01 0.07210 -1.58e-02 -7.03e-02 9.19e-01 6.49e-01
Signaling by RAF1 mutants 39 7.79e-01 8.78e-01 0.07190 4.83e-02 5.32e-02 6.02e-01 5.65e-01
Interferon gamma signaling 93 5.54e-01 7.18e-01 0.07140 4.33e-02 5.67e-02 4.71e-01 3.44e-01
Signaling by TGF-beta Receptor Complex 92 4.37e-01 6.20e-01 0.07140 -2.44e-02 6.71e-02 6.86e-01 2.66e-01
EPH-ephrin mediated repulsion of cells 50 6.48e-01 7.95e-01 0.07130 -1.61e-02 6.95e-02 8.43e-01 3.95e-01
Diseases associated with glycosaminoglycan metabolism 38 7.87e-01 8.84e-01 0.07130 -5.31e-02 -4.75e-02 5.71e-01 6.12e-01
Sialic acid metabolism 33 8.01e-01 8.92e-01 0.07080 2.70e-02 6.55e-02 7.89e-01 5.15e-01
Signal attenuation 10 9.19e-01 9.48e-01 0.07070 6.93e-02 -1.42e-02 7.04e-01 9.38e-01
Metabolism of Angiotensinogen to Angiotensins 15 8.87e-01 9.32e-01 0.07050 -7.04e-02 3.71e-03 6.37e-01 9.80e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 23 8.46e-01 9.12e-01 0.07050 -6.96e-02 -1.15e-02 5.64e-01 9.24e-01
Anchoring of the basal body to the plasma membrane 93 5.21e-01 6.93e-01 0.07040 1.65e-02 6.85e-02 7.83e-01 2.54e-01
Class B/2 (Secretin family receptors) 93 4.62e-01 6.45e-01 0.07040 -1.25e-02 6.93e-02 8.35e-01 2.48e-01
Fatty acyl-CoA biosynthesis 36 7.79e-01 8.78e-01 0.07010 -1.68e-02 -6.81e-02 8.62e-01 4.80e-01
Transport of bile salts and organic acids, metal ions and amine compounds 82 5.22e-01 6.93e-01 0.07010 5.78e-03 -6.98e-02 9.28e-01 2.74e-01
The canonical retinoid cycle in rods (twilight vision) 23 8.69e-01 9.25e-01 0.07000 -5.02e-02 -4.88e-02 6.77e-01 6.85e-01
Biological oxidations 216 2.09e-01 3.75e-01 0.07000 -7.91e-03 -6.96e-02 8.41e-01 7.80e-02
Opioid Signalling 89 4.67e-01 6.49e-01 0.06960 -6.55e-02 2.36e-02 2.86e-01 7.00e-01
COPI-dependent Golgi-to-ER retrograde traffic 98 5.31e-01 6.99e-01 0.06890 2.29e-02 6.50e-02 6.95e-01 2.66e-01
Assembly and cell surface presentation of NMDA receptors 40 7.29e-01 8.48e-01 0.06890 6.80e-02 -1.11e-02 4.57e-01 9.03e-01
Regulation of gene expression in beta cells 21 8.58e-01 9.18e-01 0.06840 6.84e-02 5.95e-04 5.87e-01 9.96e-01
Smooth Muscle Contraction 42 6.90e-01 8.22e-01 0.06840 5.06e-02 -4.61e-02 5.71e-01 6.05e-01
G alpha (12/13) signalling events 74 5.52e-01 7.17e-01 0.06820 -6.58e-02 1.79e-02 3.27e-01 7.90e-01
Lagging Strand Synthesis 19 8.96e-01 9.35e-01 0.06820 4.62e-02 5.01e-02 7.27e-01 7.05e-01
IGF1R signaling cascade 51 7.31e-01 8.49e-01 0.06790 2.62e-02 6.26e-02 7.46e-01 4.39e-01
Cilium Assembly 190 3.41e-01 5.34e-01 0.06780 4.72e-02 4.86e-02 2.61e-01 2.48e-01
Vitamin D (calciferol) metabolism 12 9.07e-01 9.41e-01 0.06720 2.74e-02 -6.14e-02 8.69e-01 7.13e-01
Vasopressin regulates renal water homeostasis via Aquaporins 42 7.06e-01 8.34e-01 0.06690 -5.73e-02 3.46e-02 5.20e-01 6.98e-01
Metabolism of carbohydrates 275 1.46e-01 2.88e-01 0.06610 -5.42e-03 6.59e-02 8.77e-01 5.99e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 198 3.49e-01 5.42e-01 0.06570 4.72e-02 4.57e-02 2.52e-01 2.67e-01
Nuclear Receptor transcription pathway 51 6.97e-01 8.28e-01 0.06550 -6.50e-02 8.50e-03 4.22e-01 9.16e-01
Hyaluronan uptake and degradation 12 9.14e-01 9.47e-01 0.06550 1.91e-02 -6.27e-02 9.09e-01 7.07e-01
Adrenaline,noradrenaline inhibits insulin secretion 28 8.26e-01 9.00e-01 0.06500 6.48e-02 -4.93e-03 5.53e-01 9.64e-01
CDC42 GTPase cycle 143 3.91e-01 5.78e-01 0.06500 -6.50e-02 1.06e-04 1.80e-01 9.98e-01
STAT3 nuclear events downstream of ALK signaling 10 9.25e-01 9.52e-01 0.06440 3.82e-02 -5.18e-02 8.34e-01 7.77e-01
G alpha (q) signalling events 207 2.57e-01 4.37e-01 0.06430 -6.42e-02 3.22e-03 1.11e-01 9.36e-01
Platelet activation, signaling and aggregation 249 1.51e-01 2.95e-01 0.06400 -5.25e-02 3.65e-02 1.53e-01 3.21e-01
Defects in vitamin and cofactor metabolism 21 8.71e-01 9.26e-01 0.06350 -6.21e-03 6.32e-02 9.61e-01 6.16e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 25 8.82e-01 9.32e-01 0.06340 -4.05e-02 -4.88e-02 7.26e-01 6.73e-01
p130Cas linkage to MAPK signaling for integrins 15 9.26e-01 9.52e-01 0.06330 -3.17e-02 -5.48e-02 8.32e-01 7.13e-01
RAB GEFs exchange GTP for GDP on RABs 82 5.43e-01 7.08e-01 0.06280 -4.45e-02 4.44e-02 4.86e-01 4.87e-01
Fatty acid metabolism 170 4.14e-01 6.02e-01 0.06280 2.55e-02 5.74e-02 5.66e-01 1.97e-01
DAG and IP3 signaling 40 7.77e-01 8.78e-01 0.06240 -6.22e-02 5.27e-03 4.96e-01 9.54e-01
Ion homeostasis 52 7.36e-01 8.53e-01 0.06220 -3.73e-03 -6.21e-02 9.63e-01 4.39e-01
Developmental Biology 1326 1.68e-03 7.18e-03 0.06220 5.68e-02 2.54e-02 5.18e-04 1.20e-01
Regulation of MITF-M-dependent genes involved in pigmentation 41 7.43e-01 8.58e-01 0.06200 4.89e-02 -3.82e-02 5.88e-01 6.72e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 8.76e-01 9.29e-01 0.06200 5.99e-02 -1.59e-02 6.43e-01 9.02e-01
Processing of SMDT1 14 9.07e-01 9.41e-01 0.06180 -2.65e-02 5.59e-02 8.64e-01 7.17e-01
Metal ion SLC transporters 23 8.47e-01 9.12e-01 0.06180 -4.64e-02 4.09e-02 7.00e-01 7.34e-01
Platelet degranulation 117 5.60e-01 7.23e-01 0.06170 -5.53e-02 -2.73e-02 3.02e-01 6.10e-01
FOXO-mediated transcription of cell cycle genes 16 9.27e-01 9.52e-01 0.06150 4.64e-02 4.03e-02 7.48e-01 7.80e-01
Potassium Channels 102 6.22e-01 7.78e-01 0.06140 -4.27e-02 -4.40e-02 4.56e-01 4.42e-01
Signaling by PDGF 57 7.68e-01 8.71e-01 0.06120 -4.53e-02 -4.11e-02 5.54e-01 5.91e-01
Interleukin-6 family signaling 24 8.48e-01 9.13e-01 0.06040 4.68e-02 -3.82e-02 6.92e-01 7.46e-01
Sema4D induced cell migration and growth-cone collapse 20 8.82e-01 9.32e-01 0.06010 -1.66e-02 5.78e-02 8.98e-01 6.55e-01
Dopamine Neurotransmitter Release Cycle 21 8.96e-01 9.35e-01 0.06010 -1.09e-02 -5.91e-02 9.31e-01 6.39e-01
Anti-inflammatory response favouring Leishmania parasite infection 75 6.72e-01 8.07e-01 0.05930 -5.91e-02 -4.95e-03 3.76e-01 9.41e-01
Leishmania parasite growth and survival 75 6.72e-01 8.07e-01 0.05930 -5.91e-02 -4.95e-03 3.76e-01 9.41e-01
Fcgamma receptor (FCGR) dependent phagocytosis 84 6.83e-01 8.16e-01 0.05910 2.70e-02 5.26e-02 6.69e-01 4.05e-01
RHO GTPases activate IQGAPs 30 8.49e-01 9.13e-01 0.05910 5.91e-02 -6.00e-05 5.75e-01 1.00e+00
Ca-dependent events 36 8.34e-01 9.07e-01 0.05900 -5.80e-02 -1.09e-02 5.47e-01 9.10e-01
Inwardly rectifying K+ channels 35 8.42e-01 9.10e-01 0.05850 -1.19e-02 -5.73e-02 9.03e-01 5.57e-01
Metabolism of water-soluble vitamins and cofactors 125 5.62e-01 7.24e-01 0.05780 1.65e-02 5.54e-02 7.50e-01 2.85e-01
PKA activation 18 8.96e-01 9.35e-01 0.05730 -3.11e-02 4.82e-02 8.19e-01 7.23e-01
TRAF6 mediated IRF7 activation 26 8.86e-01 9.32e-01 0.05700 1.15e-02 5.58e-02 9.19e-01 6.22e-01
Transcriptional regulation of brown and beige adipocyte differentiation 29 8.38e-01 9.08e-01 0.05690 -4.39e-02 3.62e-02 6.82e-01 7.36e-01
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 29 8.38e-01 9.08e-01 0.05690 -4.39e-02 3.62e-02 6.82e-01 7.36e-01
Insulin receptor signalling cascade 53 8.17e-01 8.96e-01 0.05550 3.82e-02 4.03e-02 6.31e-01 6.11e-01
Signaling by LTK 10 9.55e-01 9.72e-01 0.05550 5.61e-03 5.52e-02 9.76e-01 7.62e-01
Presynaptic function of Kainate receptors 21 8.85e-01 9.32e-01 0.05540 -3.60e-02 4.22e-02 7.75e-01 7.38e-01
MITF-M-regulated melanocyte development 131 5.45e-01 7.10e-01 0.05530 3.52e-03 5.51e-02 9.45e-01 2.76e-01
Signaling by Insulin receptor 79 7.46e-01 8.59e-01 0.05460 3.47e-02 4.22e-02 5.93e-01 5.17e-01
Constitutive Signaling by Aberrant PI3K in Cancer 82 6.82e-01 8.16e-01 0.05420 5.42e-02 -1.92e-03 3.96e-01 9.76e-01
Diseases of carbohydrate metabolism 31 8.91e-01 9.33e-01 0.05330 4.79e-02 2.33e-02 6.44e-01 8.22e-01
Gluconeogenesis 25 8.83e-01 9.32e-01 0.05250 4.81e-02 -2.12e-02 6.77e-01 8.55e-01
Ras activation upon Ca2+ influx through NMDA receptor 19 9.34e-01 9.55e-01 0.05230 -2.32e-02 -4.69e-02 8.61e-01 7.23e-01
Kinesins 59 7.57e-01 8.66e-01 0.05180 -1.61e-02 4.93e-02 8.31e-01 5.13e-01
TRP channels 27 9.07e-01 9.41e-01 0.05160 -4.86e-02 -1.72e-02 6.62e-01 8.77e-01
Surfactant metabolism 27 9.16e-01 9.47e-01 0.05100 -3.14e-02 -4.02e-02 7.78e-01 7.18e-01
RUNX2 regulates bone development 29 8.74e-01 9.29e-01 0.05090 4.73e-02 -1.88e-02 6.59e-01 8.61e-01
IRS-related events triggered by IGF1R 50 8.44e-01 9.12e-01 0.05080 2.19e-02 4.58e-02 7.89e-01 5.75e-01
Platelet homeostasis 84 7.68e-01 8.71e-01 0.05040 -3.70e-02 -3.42e-02 5.58e-01 5.88e-01
L1CAM interactions 111 6.73e-01 8.08e-01 0.05040 -1.23e-02 -4.89e-02 8.23e-01 3.74e-01
Insulin receptor recycling 28 9.15e-01 9.47e-01 0.05010 4.09e-02 2.90e-02 7.08e-01 7.90e-01
Trafficking of GluR2-containing AMPA receptors 15 9.54e-01 9.72e-01 0.04980 -2.89e-02 -4.06e-02 8.46e-01 7.86e-01
Response to elevated platelet cytosolic Ca2+ 122 6.83e-01 8.16e-01 0.04960 -4.19e-02 -2.66e-02 4.24e-01 6.12e-01
DAP12 signaling 28 8.87e-01 9.32e-01 0.04950 -1.53e-02 4.71e-02 8.89e-01 6.66e-01
IRS-mediated signalling 47 8.59e-01 9.18e-01 0.04920 1.82e-02 4.57e-02 8.29e-01 5.88e-01
Signaling by ALK 27 8.86e-01 9.32e-01 0.04890 2.92e-02 -3.92e-02 7.93e-01 7.24e-01
Late SARS-CoV-2 Infection Events 67 8.00e-01 8.92e-01 0.04870 1.24e-02 4.71e-02 8.61e-01 5.05e-01
Nucleotide catabolism 35 9.01e-01 9.39e-01 0.04840 2.68e-02 4.03e-02 7.84e-01 6.80e-01
EPH-Ephrin signaling 90 7.39e-01 8.55e-01 0.04810 8.47e-03 4.74e-02 8.90e-01 4.37e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 52 8.55e-01 9.17e-01 0.04810 2.17e-02 4.29e-02 7.86e-01 5.92e-01
Transport of small molecules 706 7.40e-02 1.75e-01 0.04730 1.01e-02 -4.62e-02 6.47e-01 3.65e-02
Glycerophospholipid biosynthesis 123 5.99e-01 7.60e-01 0.04710 -3.09e-02 3.55e-02 5.54e-01 4.96e-01
Transcriptional Regulation by NPAS4 32 8.95e-01 9.35e-01 0.04710 4.71e-02 -2.70e-04 6.45e-01 9.98e-01
Regulation of IFNG signaling 14 9.58e-01 9.74e-01 0.04700 1.35e-02 4.51e-02 9.30e-01 7.70e-01
Golgi-to-ER retrograde transport 132 6.96e-01 8.27e-01 0.04660 2.48e-02 3.94e-02 6.22e-01 4.35e-01
Integration of energy metabolism 105 6.59e-01 8.02e-01 0.04590 -3.37e-02 3.12e-02 5.51e-01 5.80e-01
Signaling by FGFR4 in disease 11 9.59e-01 9.74e-01 0.04500 3.29e-02 -3.06e-02 8.50e-01 8.60e-01
Neuronal System 389 3.91e-01 5.78e-01 0.04440 -2.89e-02 -3.37e-02 3.28e-01 2.53e-01
FGFRL1 modulation of FGFR1 signaling 13 9.65e-01 9.77e-01 0.04430 4.25e-02 1.27e-02 7.91e-01 9.37e-01
CaM pathway 34 8.85e-01 9.32e-01 0.04430 -3.92e-02 2.06e-02 6.92e-01 8.35e-01
Calmodulin induced events 34 8.85e-01 9.32e-01 0.04430 -3.92e-02 2.06e-02 6.92e-01 8.35e-01
FCGR3A-mediated IL10 synthesis 37 9.14e-01 9.47e-01 0.04420 -3.15e-02 -3.10e-02 7.40e-01 7.44e-01
Other interleukin signaling 24 9.32e-01 9.55e-01 0.04370 -2.11e-03 -4.36e-02 9.86e-01 7.11e-01
RUNX2 regulates osteoblast differentiation 22 9.39e-01 9.59e-01 0.04340 4.33e-02 2.53e-03 7.25e-01 9.84e-01
RHOA GTPase cycle 140 6.22e-01 7.78e-01 0.04310 -2.01e-02 3.81e-02 6.81e-01 4.36e-01
Signal Transduction 2495 1.35e-03 5.91e-03 0.04310 -2.72e-03 4.30e-02 8.25e-01 4.58e-04
Signaling by Receptor Tyrosine Kinases 516 2.49e-01 4.27e-01 0.04210 5.44e-04 4.21e-02 9.83e-01 1.02e-01
Gap junction degradation 12 9.61e-01 9.75e-01 0.04170 2.86e-02 -3.03e-02 8.64e-01 8.56e-01
G alpha (z) signalling events 48 8.82e-01 9.32e-01 0.04140 2.28e-03 4.14e-02 9.78e-01 6.20e-01
Metabolism of vitamins and cofactors 194 6.63e-01 8.04e-01 0.04130 3.20e-02 2.62e-02 4.42e-01 5.30e-01
RET signaling 41 9.06e-01 9.41e-01 0.04130 -4.01e-02 -9.89e-03 6.57e-01 9.13e-01
PI3K/AKT Signaling in Cancer 108 7.71e-01 8.72e-01 0.04120 4.01e-02 9.07e-03 4.71e-01 8.71e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 9.33e-01 9.55e-01 0.03960 -1.23e-02 3.77e-02 9.15e-01 7.44e-01
Diseases of metabolism 239 6.23e-01 7.78e-01 0.03960 -3.38e-02 -2.06e-02 3.69e-01 5.83e-01
Activation of kainate receptors upon glutamate binding 29 9.34e-01 9.55e-01 0.03940 -3.93e-02 -2.91e-03 7.14e-01 9.78e-01
Adenylate cyclase inhibitory pathway 14 9.69e-01 9.81e-01 0.03900 -6.73e-03 -3.84e-02 9.65e-01 8.03e-01
Sphingolipid metabolism 101 7.81e-01 8.79e-01 0.03870 -4.57e-03 3.84e-02 9.37e-01 5.05e-01
PI3K Cascade 43 9.21e-01 9.50e-01 0.03800 3.47e-02 1.54e-02 6.93e-01 8.61e-01
Plasma lipoprotein assembly, remodeling, and clearance 74 8.26e-01 9.00e-01 0.03760 1.74e-02 -3.34e-02 7.96e-01 6.20e-01
Respiratory syncytial virus (RSV) attachment and entry 21 9.52e-01 9.70e-01 0.03690 -3.55e-02 1.01e-02 7.78e-01 9.36e-01
EPHB-mediated forward signaling 41 9.15e-01 9.47e-01 0.03600 -6.32e-03 3.54e-02 9.44e-01 6.95e-01
RHOD GTPase cycle 49 9.22e-01 9.50e-01 0.03550 -3.22e-02 -1.49e-02 6.96e-01 8.57e-01
Regulation of insulin secretion 77 8.36e-01 9.07e-01 0.03540 -1.96e-02 2.95e-02 7.66e-01 6.55e-01
Downregulation of TGF-beta receptor signaling 26 9.42e-01 9.61e-01 0.03520 -1.92e-02 2.95e-02 8.65e-01 7.95e-01
GRB2 events in ERBB2 signaling 16 9.73e-01 9.83e-01 0.03500 3.40e-02 8.11e-03 8.14e-01 9.55e-01
TGF-beta receptor signaling activates SMADs 47 9.27e-01 9.52e-01 0.03470 -3.19e-02 -1.36e-02 7.05e-01 8.71e-01
Physiological factors 14 9.78e-01 9.85e-01 0.03390 3.17e-02 1.20e-02 8.37e-01 9.38e-01
MITF-M-dependent gene expression 91 8.38e-01 9.08e-01 0.03380 -7.80e-03 3.29e-02 8.98e-01 5.88e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 109 8.57e-01 9.18e-01 0.03310 2.93e-02 1.53e-02 5.97e-01 7.83e-01
Transferrin endocytosis and recycling 29 9.62e-01 9.75e-01 0.03290 2.57e-02 2.06e-02 8.11e-01 8.48e-01
Interleukin-2 family signaling 39 9.27e-01 9.52e-01 0.03260 -2.94e-02 1.41e-02 7.51e-01 8.78e-01
Beta-oxidation of very long chain fatty acids 10 9.86e-01 9.90e-01 0.03230 -2.97e-02 -1.26e-02 8.71e-01 9.45e-01
Metabolism of lipids 726 2.55e-01 4.35e-01 0.03210 -2.04e-02 2.48e-02 3.49e-01 2.56e-01
Amino acid transport across the plasma membrane 30 9.55e-01 9.72e-01 0.03110 -8.00e-04 3.11e-02 9.94e-01 7.68e-01
Activation of NMDA receptors and postsynaptic events 86 9.04e-01 9.40e-01 0.03040 1.58e-02 2.60e-02 8.00e-01 6.77e-01
Signaling by TGFB family members 157 7.91e-01 8.86e-01 0.03040 -3.03e-02 2.73e-03 5.13e-01 9.53e-01
Defects in cobalamin (B12) metabolism 13 9.86e-01 9.90e-01 0.02860 2.55e-02 1.29e-02 8.74e-01 9.36e-01
Class A/1 (Rhodopsin-like receptors) 316 7.29e-01 8.48e-01 0.02850 -1.79e-02 -2.22e-02 5.85e-01 4.97e-01
Post NMDA receptor activation events 75 9.33e-01 9.55e-01 0.02730 1.92e-02 1.94e-02 7.74e-01 7.71e-01
ROS and RNS production in phagocytes 34 9.60e-01 9.74e-01 0.02720 -3.25e-03 2.70e-02 9.74e-01 7.85e-01
Intra-Golgi traffic 43 9.61e-01 9.75e-01 0.02720 1.93e-02 1.91e-02 8.26e-01 8.28e-01
Frs2-mediated activation 12 9.87e-01 9.90e-01 0.02670 -2.55e-03 -2.66e-02 9.88e-01 8.73e-01
Metabolism of steroids 149 8.75e-01 9.29e-01 0.02670 -2.23e-02 -1.46e-02 6.38e-01 7.59e-01
Cell death signalling via NRAGE, NRIF and NADE 69 9.39e-01 9.59e-01 0.02650 1.20e-02 2.36e-02 8.63e-01 7.35e-01
p75 NTR receptor-mediated signalling 90 9.24e-01 9.52e-01 0.02570 2.35e-02 1.05e-02 7.00e-01 8.63e-01
Costimulation by the CD28 family 65 9.43e-01 9.62e-01 0.02570 -8.26e-03 -2.43e-02 9.08e-01 7.34e-01
Activation of G protein gated Potassium channels 29 9.78e-01 9.85e-01 0.02280 2.27e-02 2.02e-03 8.32e-01 9.85e-01
G protein gated Potassium channels 29 9.78e-01 9.85e-01 0.02280 2.27e-02 2.02e-03 8.32e-01 9.85e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 29 9.78e-01 9.85e-01 0.02280 2.27e-02 2.02e-03 8.32e-01 9.85e-01
Negative regulation of the PI3K/AKT network 116 9.28e-01 9.52e-01 0.02080 2.28e-03 2.06e-02 9.66e-01 7.01e-01
Hyaluronan metabolism 17 9.89e-01 9.92e-01 0.02050 2.35e-03 2.04e-02 9.87e-01 8.84e-01
Transport of vitamins, nucleosides, and related molecules 38 9.72e-01 9.83e-01 0.01990 -1.62e-02 1.14e-02 8.63e-01 9.03e-01
Glucagon-type ligand receptors 32 9.81e-01 9.86e-01 0.01980 7.76e-04 1.98e-02 9.94e-01 8.46e-01
Semaphorin interactions 61 9.63e-01 9.76e-01 0.01800 -1.13e-02 1.41e-02 8.79e-01 8.49e-01
DAP12 interactions 40 9.80e-01 9.86e-01 0.01790 -1.79e-02 -3.89e-04 8.44e-01 9.97e-01
Neurotransmitter receptors and postsynaptic signal transmission 192 8.94e-01 9.35e-01 0.01760 -1.11e-02 1.37e-02 7.90e-01 7.44e-01
Activation of GABAB receptors 43 9.76e-01 9.85e-01 0.01720 1.31e-02 -1.12e-02 8.82e-01 8.99e-01
GABA B receptor activation 43 9.76e-01 9.85e-01 0.01720 1.31e-02 -1.12e-02 8.82e-01 8.99e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 15 9.94e-01 9.96e-01 0.01600 2.31e-03 1.59e-02 9.88e-01 9.15e-01
Transmission across Chemical Synapses 255 9.83e-01 9.88e-01 0.00627 6.12e-03 -1.38e-03 8.66e-01 9.70e-01
CTLA4 inhibitory signaling 21 9.99e-01 1.00e+00 0.00481 -2.05e-04 4.81e-03 9.99e-01 9.70e-01
Signal regulatory protein family interactions 15 1.00e+00 1.00e+00 0.00401 -1.11e-03 -3.86e-03 9.94e-01 9.79e-01
Gastrin-CREB signalling pathway via PKC and MAPK 17 1.00e+00 1.00e+00 0.00371 -3.71e-03 -3.17e-05 9.79e-01 1.00e+00


Detailed Gene set reports


RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Opening
metric value
setSize 26
pMANOVA 1.16e-09
p.adjustMANOVA 2.03e-08
s.dist 0.795
s.bl 0.632
s.gu 0.481
p.bl 2.39e-08
p.gu 2.13e-05



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
MAPK3 -584.0 -6543.0
MBD2 -14677.0 64.0
UBTF -1144.0 -3199.0



Pexophagy
Pexophagy
metric value
setSize 10
pMANOVA 0.00105
p.adjustMANOVA 0.00481
s.dist 0.738
s.bl 0.603
s.gu 0.425
p.bl 0.000957
p.gu 0.02



Top 20 genes
Gene bl gu
RPS27A 2474 4870
UBB 2897 3835

Click HERE to show all gene set members

All member genes
bl gu
ATM 1403 -2649
MAP1LC3B -6219 2469
NBR1 2151 -8501
PEX5 -3257 882
RPS27A 2474 4870
SQSTM1 -3522 -746
UBA52 -1335 2310
UBB 2897 3835
UBC -1239 364
USP30 -2778 519



SIRT1 negatively regulates rRNA expression
SIRT1 negatively regulates rRNA expression
metric value
setSize 30
pMANOVA 1.68e-09
p.adjustMANOVA 2.77e-08
s.dist 0.733
s.bl 0.584
s.gu 0.442
p.bl 2.99e-08
p.gu 2.75e-05



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
TBP 2465.0 2118.0
H2BC15 1691.0 2415.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
RRP8 1246.0 -2386.0
SIRT1 -14090.0 -7987.0
TAF1A -11668.0 916.0
TAF1B -489.0 -8492.0
TAF1C -12070.0 -9033.0
TAF1D -242.0 5924.0
TBP 2465.0 2118.0



Packaging Of Telomere Ends
Packaging Of Telomere Ends
metric value
setSize 29
pMANOVA 6.57e-09
p.adjustMANOVA 9.32e-08
s.dist 0.722
s.bl 0.549
s.gu 0.469
p.bl 3.01e-07
p.gu 1.25e-05



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
TINF2 938.0 4053.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
ACD -10698.5 4997.5
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-4 410.0 -3534.0
H4C1 3228.0 5997.0
POT1 -13602.0 -10574.0
TERF1 -9783.0 -6937.0
TERF2 -13993.0 -2599.0
TERF2IP -1482.0 704.0
TINF2 938.0 4053.0



Class C/3 (Metabotropic glutamate/pheromone receptors)
Class C/3 (Metabotropic glutamate/pheromone receptors)
metric value
setSize 39
pMANOVA 5.16e-11
p.adjustMANOVA 1.2e-09
s.dist 0.699
s.bl -0.507
s.gu -0.482
p.bl 4.19e-08
p.gu 1.93e-07



Top 20 genes
Gene bl gu
TAS2R43 -17856 -15392
TAS2R39 -18435 -14596
TAS2R1 -18100 -14766
TAS2R3 -18482 -14363
TAS2R42 -18398 -14385
TAS2R20 -18429 -14250
TAS2R30 -17943 -14511
TAS2R50 -18497 -13978
TAS2R10 -18424 -13961
TAS2R8 -18332 -13704
TAS2R9 -18213 -13787
GPRC6A -17834 -13713
TAS2R19 -15936 -15251
TAS2R14 -18072 -13336
TAS2R41 -16568 -13775
TAS2R16 -15798 -13703
TAS2R7 -18030 -12000
TAS2R60 -14353 -14924
TAS2R4 -11890 -15336
TAS2R5 -16147 -9902

Click HERE to show all gene set members

All member genes
bl gu
CASR -4185 -671
GABBR1 -10134 -8723
GABBR2 -3658 -4632
GPRC6A -17834 -13713
GRM1 -14284 -10788
GRM2 -5504 776
GRM3 -7285 -9667
GRM4 -4486 -7923
GRM5 -14419 -7503
GRM6 -9564 -10725
GRM7 -7035 -10058
GRM8 -3002 -10836
TAS1R1 -2485 -10194
TAS1R2 -2101 3661
TAS1R3 -8648 3952
TAS2R1 -18100 -14766
TAS2R10 -18424 -13961
TAS2R13 -16324 4148
TAS2R14 -18072 -13336
TAS2R16 -15798 -13703
TAS2R19 -15936 -15251
TAS2R20 -18429 -14250
TAS2R3 -18482 -14363
TAS2R30 -17943 -14511
TAS2R31 -17684 -3837
TAS2R38 -7460 -10264
TAS2R39 -18435 -14596
TAS2R4 -11890 -15336
TAS2R40 -16226 1373
TAS2R41 -16568 -13775
TAS2R42 -18398 -14385
TAS2R43 -17856 -15392
TAS2R46 -18171 -8572
TAS2R5 -16147 -9902
TAS2R50 -18497 -13978
TAS2R60 -14353 -14924
TAS2R7 -18030 -12000
TAS2R8 -18332 -13704
TAS2R9 -18213 -13787



Assembly of the ORC complex at the origin of replication
Assembly of the ORC complex at the origin of replication
metric value
setSize 32
pMANOVA 1.11e-08
p.adjustMANOVA 1.47e-07
s.dist 0.679
s.bl 0.477
s.gu 0.484
p.bl 3.05e-06
p.gu 2.17e-06



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
H2BC9 3001.5 1112.5
ORC6 549.0 2795.0

Click HERE to show all gene set members

All member genes
bl gu
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
KPNA1 -14970.0 -1899.0
KPNA6 -6639.0 4126.0
KPNB1 2029.0 -128.0
ORC1 -4165.0 4487.0
ORC2 -11476.0 -7345.0
ORC3 -9469.0 2115.0
ORC4 -15664.0 -2229.0
ORC5 -15725.0 -5092.0
ORC6 549.0 2795.0



DNA methylation
DNA methylation
metric value
setSize 28
pMANOVA 1.95e-07
p.adjustMANOVA 1.81e-06
s.dist 0.666
s.bl 0.504
s.gu 0.434
p.bl 3.81e-06
p.gu 6.92e-05



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
DNMT1 -10941.0 -6087.0
DNMT3A -12498.0 -1582.0
DNMT3B -15370.0 -1653.0
DNMT3L -6330.0 -11777.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
UHRF1 -12272.0 -1344.0



Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
metric value
setSize 32
pMANOVA 3.14e-08
p.adjustMANOVA 3.77e-07
s.dist 0.659
s.bl 0.456
s.gu 0.476
p.bl 7.9e-06
p.gu 3.13e-06



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
ATF7IP -3220.0 -8233.0
EHMT1 -13462.0 -405.0
EHMT2 -9648.0 -1541.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
MORC2 -4314.0 -280.0
MPHOSPH8 -12864.0 1438.0
PPHLN1 -14325.0 -6264.0
RBM7 -6982.0 2026.0
SETDB1 -3635.0 4771.0
ZCCHC8 -14332.0 2603.0



Defective pyroptosis
Defective pyroptosis
metric value
setSize 34
pMANOVA 1.3e-08
p.adjustMANOVA 1.68e-07
s.dist 0.656
s.bl 0.446
s.gu 0.481
p.bl 6.9e-06
p.gu 1.19e-06



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
PRIM1 1900.0 4123.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
RBBP4 1101.0 3128.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
DNMT1 -10941.0 -6087.0
DNMT3A -12498.0 -1582.0
DNMT3B -15370.0 -1653.0
EED -6315.0 3767.0
EZH2 -16231.0 -760.0
GSDME -10038.0 -1079.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
POLA2 -382.0 2365.0
PRIM1 1900.0 4123.0
PRIM2 -5090.0 -7881.0
RBBP4 1101.0 3128.0
SUZ12 -18160.0 3473.0



Deposition of new CENPA-containing nucleosomes at the centromere
Deposition of new CENPA-containing nucleosomes at the centromere
metric value
setSize 46
pMANOVA 2.88e-11
p.adjustMANOVA 6.9e-10
s.dist 0.652
s.bl 0.475
s.gu 0.447
p.bl 2.48e-08
p.gu 1.58e-07



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
CENPK 2050.0 5619.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
RBBP4 1101.0 3128.0
H2BC9 3001.5 1112.5
CENPC 2620.0 680.0
CENPW 2602.0 420.0

Click HERE to show all gene set members

All member genes
bl gu
CENPA -12882.0 5433.0
CENPC 2620.0 680.0
CENPH -10144.0 382.0
CENPK 2050.0 5619.0
CENPL -3245.0 -2417.0
CENPM -5999.0 5841.0
CENPN 49.0 -1766.0
CENPO -10447.0 3800.0
CENPP -13811.0 -3578.0
CENPQ -287.0 -5255.0
CENPT -3226.0 -5183.0
CENPU -7442.0 -6819.0
CENPW 2602.0 420.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H4C1 3228.0 5997.0
HJURP -544.0 -6597.0
ITGB3BP -662.0 5006.0
KNL1 -4176.0 72.0
MIS18A -12177.0 -9603.0
MIS18BP1 -7878.0 242.0
NPM1 -7392.0 5985.0
OIP5 -41.0 4536.0
RBBP4 1101.0 3128.0
RSF1 -15707.0 -2802.0
RUVBL1 -3090.0 -10844.0
SMARCA5 -2082.0 2281.0



Nucleosome assembly
Nucleosome assembly
metric value
setSize 46
pMANOVA 2.88e-11
p.adjustMANOVA 6.9e-10
s.dist 0.652
s.bl 0.475
s.gu 0.447
p.bl 2.48e-08
p.gu 1.58e-07



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
CENPK 2050.0 5619.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
RBBP4 1101.0 3128.0
H2BC9 3001.5 1112.5
CENPC 2620.0 680.0
CENPW 2602.0 420.0

Click HERE to show all gene set members

All member genes
bl gu
CENPA -12882.0 5433.0
CENPC 2620.0 680.0
CENPH -10144.0 382.0
CENPK 2050.0 5619.0
CENPL -3245.0 -2417.0
CENPM -5999.0 5841.0
CENPN 49.0 -1766.0
CENPO -10447.0 3800.0
CENPP -13811.0 -3578.0
CENPQ -287.0 -5255.0
CENPT -3226.0 -5183.0
CENPU -7442.0 -6819.0
CENPW 2602.0 420.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H4C1 3228.0 5997.0
HJURP -544.0 -6597.0
ITGB3BP -662.0 5006.0
KNL1 -4176.0 72.0
MIS18A -12177.0 -9603.0
MIS18BP1 -7878.0 242.0
NPM1 -7392.0 5985.0
OIP5 -41.0 4536.0
RBBP4 1101.0 3128.0
RSF1 -15707.0 -2802.0
RUVBL1 -3090.0 -10844.0
SMARCA5 -2082.0 2281.0



Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
metric value
setSize 29
pMANOVA 2.42e-07
p.adjustMANOVA 2.2e-06
s.dist 0.651
s.bl 0.463
s.gu 0.457
p.bl 1.56e-05
p.gu 2.08e-05



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
KDM1A -12823.0 1013.0
KDM4C -13635.0 -7364.0
KLK2 -8019.0 -8726.0
KLK3 -11675.0 260.0
NCOA2 -15960.0 -5219.0
PKN1 -10596.0 5188.0



Eicosanoids
Eicosanoids
metric value
setSize 12
pMANOVA 0.000199
p.adjustMANOVA 0.00105
s.dist 0.65
s.bl 0.639
s.gu -0.118
p.bl 0.000126
p.gu 0.481



Top 20 genes
Gene bl gu
CYP8B1 2563 -13152
CYP4F2 2105 -11869
CYP4F8 1105 -13856
CYP4F11 605 -10802
PTGIS 152 -12374

Click HERE to show all gene set members

All member genes
bl gu
CYP4A11 3255 1201
CYP4A22 2674 3658
CYP4B1 -7931 -12664
CYP4F11 605 -10802
CYP4F12 -797 6212
CYP4F2 2105 -11869
CYP4F22 -868 -3527
CYP4F3 -22 3027
CYP4F8 1105 -13856
CYP8B1 2563 -13152
PTGIS 152 -12374
TBXAS1 -9364 -4282



Inhibition of DNA recombination at telomere
Inhibition of DNA recombination at telomere
metric value
setSize 43
pMANOVA 2e-10
p.adjustMANOVA 4.12e-09
s.dist 0.64
s.bl 0.535
s.gu 0.352
p.bl 1.27e-09
p.gu 6.57e-05



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
POLR2K 3400.0 5975.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
POLR2J 2869.0 5818.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
TINF2 938.0 4053.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
ACD -10698.5 4997.5
DAXX -3636.0 -7251.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H3-4 410.0 -3534.0
H4C1 3228.0 5997.0
POLR2A -8467.0 -4743.0
POLR2B -1287.0 -2694.0
POLR2C -1242.0 -9483.0
POLR2D -4681.0 -4783.0
POLR2E -104.0 -3006.0
POLR2F -6782.0 -10514.0
POLR2G 1811.0 -803.0
POLR2H 2455.0 -12983.0
POLR2I -1031.0 3729.0
POLR2J 2869.0 5818.0
POLR2K 3400.0 5975.0
POLR2L -8826.0 -906.0
POT1 -13602.0 -10574.0
TERF1 -9783.0 -6937.0
TERF2 -13993.0 -2599.0
TERF2IP -1482.0 704.0
TINF2 938.0 4053.0



SARS-CoV-1 modulates host translation machinery
SARS-CoV-1 modulates host translation machinery
metric value
setSize 34
pMANOVA 2.43e-08
p.adjustMANOVA 3.01e-07
s.dist 0.633
s.bl 0.551
s.gu 0.311
p.bl 2.67e-08
p.gu 0.00169



Top 20 genes
Gene bl gu
HNRNPA1 3017 5978
RPS17 3433 4407
RPS27A 2474 4870
RPS19 2467 4525
EEF1A1 1341 5960
RPS27 1007 5691
RPS23 1310 2106
RPSA 417 6081
RPS16 546 3749
RPS18 772 1775
RPS8 54 4142
RPS3 96 1863

Click HERE to show all gene set members

All member genes
bl gu
EEF1A1 1341 5960
FAU 501 -9349
HNRNPA1 3017 5978
RPS10 -3720 1709
RPS11 2174 -12139
RPS12 2996 -779
RPS13 -3689 -12947
RPS14 -8441 6040
RPS15 -3429 2966
RPS15A -3309 2257
RPS16 546 3749
RPS17 3433 4407
RPS18 772 1775
RPS19 2467 4525
RPS2 213 -11527
RPS20 -1332 -4105
RPS21 -78 -5475
RPS23 1310 2106
RPS24 -5323 5191
RPS25 -826 -1722
RPS26 -3319 5742
RPS27 1007 5691
RPS27A 2474 4870
RPS27L 670 -6194
RPS28 -12426 -3732
RPS29 1038 -11031
RPS3 96 1863
RPS3A -742 -2566
RPS5 -9328 -13724
RPS6 -9787 449
RPS7 -4504 -4285
RPS8 54 4142
RPS9 -6281 -7716
RPSA 417 6081



Cleavage of the damaged pyrimidine
Cleavage of the damaged pyrimidine
metric value
setSize 38
pMANOVA 6.31e-09
p.adjustMANOVA 9.11e-08
s.dist 0.633
s.bl 0.45
s.gu 0.444
p.bl 1.54e-06
p.gu 2.13e-06



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
TINF2 938.0 4053.0
H2BC9 3001.5 1112.5
SMUG1 802.0 1727.0
MBD4 141.0 2501.0

Click HERE to show all gene set members

All member genes
bl gu
ACD -10698.5 4997.5
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-4 410.0 -3534.0
H4C1 3228.0 5997.0
MBD4 141.0 2501.0
NEIL1 -13402.0 4332.0
NEIL2 -243.0 1434.0
NEIL3 -10254.0 -5603.0
NTHL1 -13199.0 987.0
OGG1 -14526.0 -6239.0
POT1 -13602.0 -10574.0
SMUG1 802.0 1727.0
TDG -4742.0 -3501.0
TERF1 -9783.0 -6937.0
TERF2 -13993.0 -2599.0
TERF2IP -1482.0 704.0
TINF2 938.0 4053.0
UNG -388.0 1356.0



Depyrimidination
Depyrimidination
metric value
setSize 38
pMANOVA 6.31e-09
p.adjustMANOVA 9.11e-08
s.dist 0.633
s.bl 0.45
s.gu 0.444
p.bl 1.54e-06
p.gu 2.13e-06



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
TINF2 938.0 4053.0
H2BC9 3001.5 1112.5
SMUG1 802.0 1727.0
MBD4 141.0 2501.0

Click HERE to show all gene set members

All member genes
bl gu
ACD -10698.5 4997.5
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-4 410.0 -3534.0
H4C1 3228.0 5997.0
MBD4 141.0 2501.0
NEIL1 -13402.0 4332.0
NEIL2 -243.0 1434.0
NEIL3 -10254.0 -5603.0
NTHL1 -13199.0 987.0
OGG1 -14526.0 -6239.0
POT1 -13602.0 -10574.0
SMUG1 802.0 1727.0
TDG -4742.0 -3501.0
TERF1 -9783.0 -6937.0
TERF2 -13993.0 -2599.0
TERF2IP -1482.0 704.0
TINF2 938.0 4053.0
UNG -388.0 1356.0



Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
metric value
setSize 38
pMANOVA 6.31e-09
p.adjustMANOVA 9.11e-08
s.dist 0.633
s.bl 0.45
s.gu 0.444
p.bl 1.54e-06
p.gu 2.13e-06



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
TINF2 938.0 4053.0
H2BC9 3001.5 1112.5
SMUG1 802.0 1727.0
MBD4 141.0 2501.0

Click HERE to show all gene set members

All member genes
bl gu
ACD -10698.5 4997.5
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-4 410.0 -3534.0
H4C1 3228.0 5997.0
MBD4 141.0 2501.0
NEIL1 -13402.0 4332.0
NEIL2 -243.0 1434.0
NEIL3 -10254.0 -5603.0
NTHL1 -13199.0 987.0
OGG1 -14526.0 -6239.0
POT1 -13602.0 -10574.0
SMUG1 802.0 1727.0
TDG -4742.0 -3501.0
TERF1 -9783.0 -6937.0
TERF2 -13993.0 -2599.0
TERF2IP -1482.0 704.0
TINF2 938.0 4053.0
UNG -388.0 1356.0



TICAM1-dependent activation of IRF3/IRF7
TICAM1-dependent activation of IRF3/IRF7
metric value
setSize 13
pMANOVA 0.0019
p.adjustMANOVA 0.00798
s.dist 0.623
s.bl 0.447
s.gu 0.434
p.bl 0.0053
p.gu 0.0067



Top 20 genes
Gene bl gu
TLR3 2913 4674
RPS27A 2474 4870
UBB 2897 3835

Click HERE to show all gene set members

All member genes
bl gu
IKBKE -2659 -6879
IRF3 -1223 552
IRF7 -2273 2749
OPTN -4563 -7998
RPS27A 2474 4870
TANK -8894 1711
TBK1 -5573 2895
TICAM1 -363 -281
TLR3 2913 4674
TRAF3 -15076 -3102
UBA52 -1335 2310
UBB 2897 3835
UBC -1239 364



Scavenging of heme from plasma
Scavenging of heme from plasma
metric value
setSize 12
pMANOVA 0.00327
p.adjustMANOVA 0.0125
s.dist 0.62
s.bl -0.44
s.gu -0.436
p.bl 0.00824
p.gu 0.00894



Top 20 genes
Gene bl gu
HBA1 -18032 -15071
HBB -17837 -14302
ALB -18284 -13666
APOL1 -18076 -10931
HPX -16481 -10766
AMBP -10437 -12833
CD163 -14719 -7877
HPR -13161 -6928
JCHAIN -5879 -14330
APOA1 -2396 -3390
LRP1 -2118 -2572

Click HERE to show all gene set members

All member genes
bl gu
ALB -18284 -13666
AMBP -10437 -12833
APOA1 -2396 -3390
APOL1 -18076 -10931
CD163 -14719 -7877
HBA1 -18032 -15071
HBB -17837 -14302
HP -13263 1736
HPR -13161 -6928
HPX -16481 -10766
JCHAIN -5879 -14330
LRP1 -2118 -2572



Chromatin modifications during the maternal to zygotic transition (MZT)
Chromatin modifications during the maternal to zygotic transition (MZT)
metric value
setSize 32
pMANOVA 2.49e-07
p.adjustMANOVA 2.24e-06
s.dist 0.617
s.bl 0.483
s.gu 0.384
p.bl 2.26e-06
p.gu 0.000173



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
AICDA -3871.0 -11343.0
DPPA3 -16152.0 -13392.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
KDM5A -10936.0 -5662.0
KDM5B -9422.0 -3364.0
KDM6B -5399.0 4696.0
METTL23 -1461.0 -10505.0
TET3 -13418.0 764.0
UHRF1 -12272.0 -1344.0
UNG -388.0 1356.0



Cleavage of the damaged purine
Cleavage of the damaged purine
metric value
setSize 33
pMANOVA 1.91e-07
p.adjustMANOVA 1.8e-06
s.dist 0.615
s.bl 0.437
s.gu 0.432
p.bl 1.36e-05
p.gu 1.76e-05



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
TINF2 938.0 4053.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
ACD -10698.5 4997.5
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-4 410.0 -3534.0
H4C1 3228.0 5997.0
MPG -13324.0 2739.0
MUTYH -9204.0 -1212.0
NEIL3 -10254.0 -5603.0
OGG1 -14526.0 -6239.0
POT1 -13602.0 -10574.0
TERF1 -9783.0 -6937.0
TERF2 -13993.0 -2599.0
TERF2IP -1482.0 704.0
TINF2 938.0 4053.0



Depurination
Depurination
metric value
setSize 33
pMANOVA 1.91e-07
p.adjustMANOVA 1.8e-06
s.dist 0.615
s.bl 0.437
s.gu 0.432
p.bl 1.36e-05
p.gu 1.76e-05



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
TINF2 938.0 4053.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
ACD -10698.5 4997.5
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-4 410.0 -3534.0
H4C1 3228.0 5997.0
MPG -13324.0 2739.0
MUTYH -9204.0 -1212.0
NEIL3 -10254.0 -5603.0
OGG1 -14526.0 -6239.0
POT1 -13602.0 -10574.0
TERF1 -9783.0 -6937.0
TERF2 -13993.0 -2599.0
TERF2IP -1482.0 704.0
TINF2 938.0 4053.0



Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
metric value
setSize 33
pMANOVA 1.91e-07
p.adjustMANOVA 1.8e-06
s.dist 0.615
s.bl 0.437
s.gu 0.432
p.bl 1.36e-05
p.gu 1.76e-05



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
TINF2 938.0 4053.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
ACD -10698.5 4997.5
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-4 410.0 -3534.0
H4C1 3228.0 5997.0
MPG -13324.0 2739.0
MUTYH -9204.0 -1212.0
NEIL3 -10254.0 -5603.0
OGG1 -14526.0 -6239.0
POT1 -13602.0 -10574.0
TERF1 -9783.0 -6937.0
TERF2 -13993.0 -2599.0
TERF2IP -1482.0 704.0
TINF2 938.0 4053.0



Sensory perception of sweet, bitter, and umami (glutamate) taste
Sensory perception of sweet, bitter, and umami (glutamate) taste
metric value
setSize 41
pMANOVA 4.38e-09
p.adjustMANOVA 6.61e-08
s.dist 0.613
s.bl -0.482
s.gu -0.379
p.bl 9.39e-08
p.gu 2.69e-05



Top 20 genes
Gene bl gu
TAS2R43 -17856 -15392
GNAT3 -18381 -14664
TAS2R39 -18435 -14596
TAS2R1 -18100 -14766
TAS2R3 -18482 -14363
TAS2R20 -18429 -14250
TAS2R30 -17943 -14511
TAS2R50 -18497 -13978
TAS2R10 -18424 -13961
TAS2R8 -18332 -13704
TAS2R14 -18072 -13336
TAS2R41 -16568 -13775
TAS2R16 -15798 -13703
TAS2R7 -18030 -12000
TAS2R4 -11890 -15336
TAS2R5 -16147 -9902
TAS2R46 -18171 -8572
GRM1 -14284 -10788
SCN1B -14370 -10242
SCN9A -13814 -9919

Click HERE to show all gene set members

All member genes
bl gu
CALHM1 -11267 -5599
CALHM3 -11738 -11535
GNAT3 -18381 -14664
GNB1 -14809 -3010
GNB3 -11468 5124
GNG13 -4194 28
GRM1 -14284 -10788
GRM4 -4486 -7923
ITPR3 -10289 -11406
PLCB2 -12756 -7112
SCN1B -14370 -10242
SCN2A -9740 -10416
SCN2B -8208 -650
SCN3A -9780 -8730
SCN4B -5614 -4956
SCN9A -13814 -9919
TAS1R1 -2485 -10194
TAS1R2 -2101 3661
TAS1R3 -8648 3952
TAS2R1 -18100 -14766
TAS2R10 -18424 -13961
TAS2R13 -16324 4148
TAS2R14 -18072 -13336
TAS2R16 -15798 -13703
TAS2R20 -18429 -14250
TAS2R3 -18482 -14363
TAS2R30 -17943 -14511
TAS2R31 -17684 -3837
TAS2R38 -7460 -10264
TAS2R39 -18435 -14596
TAS2R4 -11890 -15336
TAS2R40 -16226 1373
TAS2R41 -16568 -13775
TAS2R43 -17856 -15392
TAS2R46 -18171 -8572
TAS2R5 -16147 -9902
TAS2R50 -18497 -13978
TAS2R7 -18030 -12000
TAS2R8 -18332 -13704
TRPM4 -4963 -9369
TRPM5 -3066 -4322



Condensation of Prophase Chromosomes
Condensation of Prophase Chromosomes
metric value
setSize 36
pMANOVA 6.52e-08
p.adjustMANOVA 6.82e-07
s.dist 0.608
s.bl 0.452
s.gu 0.406
p.bl 2.64e-06
p.gu 2.43e-05



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
H2BC9 3001.5 1112.5
SMC2 103.0 5256.0

Click HERE to show all gene set members

All member genes
bl gu
CCNB1 -13974.0 4598.0
CDK1 -585.0 -901.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H3-4 410.0 -3534.0
H4C1 3228.0 5997.0
KMT5A -2900.0 4455.0
MCPH1 -17396.0 -9092.0
NCAPD3 -9396.0 -4662.0
NCAPG2 -15243.0 -9373.0
NCAPH2 -15700.0 -10861.0
PLK1 -2822.0 214.0
RB1 -9910.0 -3807.0
SET -1174.0 -5545.0
SMC2 103.0 5256.0
SMC4 -6143.0 3075.0



Base-Excision Repair, AP Site Formation
Base-Excision Repair, AP Site Formation
metric value
setSize 40
pMANOVA 1.16e-08
p.adjustMANOVA 1.52e-07
s.dist 0.607
s.bl 0.412
s.gu 0.445
p.bl 6.57e-06
p.gu 1.09e-06



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
TINF2 938.0 4053.0
H2BC9 3001.5 1112.5
SMUG1 802.0 1727.0
MBD4 141.0 2501.0

Click HERE to show all gene set members

All member genes
bl gu
ACD -10698.5 4997.5
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-4 410.0 -3534.0
H4C1 3228.0 5997.0
MBD4 141.0 2501.0
MPG -13324.0 2739.0
MUTYH -9204.0 -1212.0
NEIL1 -13402.0 4332.0
NEIL2 -243.0 1434.0
NEIL3 -10254.0 -5603.0
NTHL1 -13199.0 987.0
OGG1 -14526.0 -6239.0
POT1 -13602.0 -10574.0
SMUG1 802.0 1727.0
TDG -4742.0 -3501.0
TERF1 -9783.0 -6937.0
TERF2 -13993.0 -2599.0
TERF2IP -1482.0 704.0
TINF2 938.0 4053.0
UNG -388.0 1356.0



Complex III assembly
Complex III assembly
metric value
setSize 24
pMANOVA 1.54e-05
p.adjustMANOVA 9.98e-05
s.dist 0.601
s.bl 0.313
s.gu 0.513
p.bl 0.00791
p.gu 1.34e-05



Top 20 genes
Gene bl gu
UQCC6 3185 5201
ISCU 1860 5854
UQCC5 2573 3960
HSCB 1439 5012
UQCC2 1318 5262
UQCR11 1720 1053
UQCRFS1 295 5272
UQCRB 1663 343

Click HERE to show all gene set members

All member genes
bl gu
BCS1L -11029 -7455
CYC1 -1682 6252
FXN -10329 -4491
HSCB 1439 5012
HSPA9 -12540 -4829
ISCU 1860 5854
LETM1 -5239 2264
LYRM4 -11713 -5918
LYRM7 -9863 -461
NFS1 -7462 2490
TTC19 -11923 3542
UQCC1 -12810 3034
UQCC2 1318 5262
UQCC3 -4181 -3169
UQCC5 2573 3960
UQCC6 3185 5201
UQCR10 1851 -7168
UQCR11 1720 1053
UQCRB 1663 343
UQCRC1 -1391 4743
UQCRC2 -3888 2828
UQCRFS1 295 5272
UQCRH -3748 3583
UQCRQ -8229 4354



Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
metric value
setSize 11
pMANOVA 0.00754
p.adjustMANOVA 0.0264
s.dist 0.598
s.bl 0.431
s.gu 0.414
p.bl 0.0133
p.gu 0.0173



Top 20 genes
Gene bl gu
TLR3 2913 4674
RPS27A 2474 4870
UBB 2897 3835

Click HERE to show all gene set members

All member genes
bl gu
IKBKE -2659 -6879
OPTN -4563 -7998
RPS27A 2474 4870
TANK -8894 1711
TBK1 -5573 2895
TICAM1 -363 -281
TLR3 2913 4674
TRAF3 -15076 -3102
UBA52 -1335 2310
UBB 2897 3835
UBC -1239 364



ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
metric value
setSize 38
pMANOVA 7.66e-08
p.adjustMANOVA 7.86e-07
s.dist 0.589
s.bl 0.393
s.gu 0.438
p.bl 2.72e-05
p.gu 2.89e-06



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
RBBP4 1101.0 3128.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
CBX3 -3158.0 5067.0
CHD3 -8113.0 -4915.0
CHD4 -2033.0 -6172.0
EHMT2 -9648.0 -1541.0
ERCC6 -16567.0 -3184.0
GATAD2A -7443.0 1953.0
GATAD2B -4071.0 2305.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
HDAC1 -13726.0 2453.0
HDAC2 -11855.0 -6787.0
MBD3 -11439.0 -2012.0
MTA1 -14171.0 -454.0
MTA2 -3792.0 -5639.0
MTA3 -13921.0 -6452.0
RBBP4 1101.0 3128.0
TTF1 -6097.0 5826.0



PRC2 methylates histones and DNA
PRC2 methylates histones and DNA
metric value
setSize 35
pMANOVA 2.6e-07
p.adjustMANOVA 2.32e-06
s.dist 0.589
s.bl 0.363
s.gu 0.463
p.bl 0.000201
p.gu 2.09e-06



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
RBBP4 1101.0 3128.0
H2BC9 3001.5 1112.5

Click HERE to show all gene set members

All member genes
bl gu
AEBP2 -15485.0 -11267.0
DNMT1 -10941.0 -6087.0
DNMT3A -12498.0 -1582.0
DNMT3B -15370.0 -1653.0
EED -6315.0 3767.0
EZH2 -16231.0 -760.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
JARID2 -13676.0 1427.0
MTF2 -10972.0 5147.0
PHF1 -5305.0 -5327.0
PHF19 -2963.0 1564.0
RBBP4 1101.0 3128.0
SUZ12 -18160.0 3473.0



Senescence-Associated Secretory Phenotype (SASP)
Senescence-Associated Secretory Phenotype (SASP)
metric value
setSize 74
pMANOVA 2.21e-14
p.adjustMANOVA 8.86e-13
s.dist 0.585
s.bl 0.4
s.gu 0.427
p.bl 2.54e-09
p.gu 2.13e-10



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
CXCL8 3124.0 4948.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
RPS27A 2474.0 4870.0
ANAPC10 1889.0 6216.0
UBB 2897.0 3835.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
CDK4 1624.0 4652.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
H2BC9 3001.5 1112.5
ANAPC1 920.0 3151.0

Click HERE to show all gene set members

All member genes
bl gu
ANAPC1 920.0 3151.0
ANAPC10 1889.0 6216.0
ANAPC11 -209.0 206.0
ANAPC15 -348.0 4476.0
ANAPC16 -4019.0 4909.0
ANAPC2 -7946.0 3718.0
ANAPC4 -11522.0 -5185.0
ANAPC5 -12364.0 3458.0
ANAPC7 427.0 1604.0
CCNA1 -6749.0 -5180.0
CCNA2 -415.0 362.0
CDC16 -3440.0 -1814.0
CDC23 1842.0 -10239.0
CDC26 -3595.0 4573.0
CDC27 -15650.0 -11665.0
CDK2 -9336.0 -1131.0
CDK4 1624.0 4652.0
CDK6 -8699.0 -2598.0
CDKN1A -3477.0 5305.0
CDKN1B -344.0 -942.0
CDKN2A 748.0 2636.0
CDKN2B -447.0 6184.0
CDKN2C 646.0 3000.0
CDKN2D -11789.0 -804.0
CEBPB -8316.0 5524.0
CXCL8 3124.0 4948.0
EHMT1 -13462.0 -405.0
EHMT2 -9648.0 -1541.0
FOS -6090.0 -1403.0
FZR1 -13711.0 4744.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
IGFBP7 -5655.0 -5799.0
IL1A -1059.0 -13210.0
IL6 -2910.0 2086.0
JUN -100.0 -2472.0
MAPK1 -7631.0 -9142.0
MAPK3 -584.0 -6543.0
MAPK7 -6891.0 -5209.0
NFKB1 -1598.0 -5667.0
RELA -8702.0 -484.0
RPS27A 2474.0 4870.0
RPS6KA1 -14124.0 5831.0
RPS6KA2 -8392.0 -6724.0
STAT3 -881.0 -6798.0
UBA52 -1335.0 2310.0
UBB 2897.0 3835.0
UBC -1239.0 364.0
UBE2C 121.0 -2231.0
UBE2D1 -9408.0 1824.0
UBE2E1 -11525.0 325.0
UBE2S -9680.0 4625.0
VENTX -11173.0 2151.0



APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Cyclin B
metric value
setSize 24
pMANOVA 4.35e-05
p.adjustMANOVA 0.000261
s.dist 0.574
s.bl 0.31
s.gu 0.483
p.bl 0.00852
p.gu 4.23e-05



Top 20 genes
Gene bl gu
RPS27A 2474 4870
ANAPC10 1889 6216
UBB 2897 3835
ANAPC1 920 3151
ANAPC7 427 1604

Click HERE to show all gene set members

All member genes
bl gu
ANAPC1 920 3151
ANAPC10 1889 6216
ANAPC11 -209 206
ANAPC15 -348 4476
ANAPC16 -4019 4909
ANAPC2 -7946 3718
ANAPC4 -11522 -5185
ANAPC5 -12364 3458
ANAPC7 427 1604
CCNB1 -13974 4598
CDC16 -3440 -1814
CDC20 -4645 389
CDC23 1842 -10239
CDC26 -3595 4573
CDC27 -15650 -11665
CDK1 -585 -901
RPS27A 2474 4870
UBA52 -1335 2310
UBB 2897 3835
UBC -1239 364
UBE2C 121 -2231
UBE2D1 -9408 1824
UBE2E1 -11525 325
UBE2S -9680 4625



PINK1-PRKN Mediated Mitophagy
PINK1-PRKN Mediated Mitophagy
metric value
setSize 31
pMANOVA 3.93e-06
p.adjustMANOVA 2.89e-05
s.dist 0.568
s.bl 0.366
s.gu 0.434
p.bl 0.00042
p.gu 2.87e-05



Top 20 genes
Gene bl gu
RPS27A 2474 4870
UBB 2897 3835
TOMM70 1451 3613
UBE2L3 1309 1861
TOMM6 2058 1025

Click HERE to show all gene set members

All member genes
bl gu
ATG12 -6252 -5428
ATG5 -9771 1449
ATG9A -8391 661
MAP1LC3A -14093 2289
MAP1LC3B -6219 2469
MFN1 -446 3928
MFN2 -6954 959
MTERF3 -151 1858
OPTN -4563 -7998
PINK1 -1215 3320
RPS27A 2474 4870
SQSTM1 -3522 -746
TBK1 -5573 2895
TOMM20 -4413 -3711
TOMM22 -3414 -1736
TOMM40 -5420 6142
TOMM5 -11317 -1961
TOMM6 2058 1025
TOMM7 -2795 4553
TOMM70 1451 3613
UBA52 -1335 2310
UBB 2897 3835
UBC -1239 364
UBE2D2 -1377 3901
UBE2D3 -3083 -5312
UBE2L3 1309 1861
UBE2N -1608 -6247
UBE2V1 -1806 5345
VDAC1 -14399 -1002
VDAC2 -2768 -4433
VDAC3 771 -5678



B-WICH complex positively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
metric value
setSize 54
pMANOVA 8.52e-10
p.adjustMANOVA 1.53e-08
s.dist 0.556
s.bl 0.444
s.gu 0.334
p.bl 1.62e-08
p.gu 2.22e-05



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
POLR2K 3400.0 5975.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
H2BC26 1094.0 5119.0
TBP 2465.0 2118.0
POLR1H 2042.0 2060.0
H2BC15 1691.0 2415.0
H2BC9 3001.5 1112.5
DDX21 709.0 4226.0

Click HERE to show all gene set members

All member genes
bl gu
ACTB 1802.0 -4010.0
BAZ1B -2112.0 2447.0
DDX21 709.0 4226.0
DEK -979.0 2011.0
EP300 -3408.0 201.0
ERCC6 -16567.0 -3184.0
GSK3B -5010.0 -11030.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
KAT2A -11630.0 2329.0
KAT2B -3572.0 -726.0
MYBBP1A -11238.0 -5396.0
MYO1C -8988.0 113.0
POLR1A -5362.0 1239.0
POLR1B -8676.0 -10663.0
POLR1C -1702.0 -6407.0
POLR1D -8592.0 -2552.0
POLR1E -4774.0 3372.0
POLR1F 2307.0 -11659.0
POLR1G -14360.0 -1304.0
POLR1H 2042.0 2060.0
POLR2E -104.0 -3006.0
POLR2F -6782.0 -10514.0
POLR2H 2455.0 -12983.0
POLR2K 3400.0 5975.0
POLR2L -8826.0 -906.0
SF3B1 -13038.0 -5184.0
SMARCA5 -2082.0 2281.0
TAF1A -11668.0 916.0
TAF1B -489.0 -8492.0
TAF1C -12070.0 -9033.0
TAF1D -242.0 5924.0
TBP 2465.0 2118.0



Diseases of programmed cell death
Diseases of programmed cell death
metric value
setSize 66
pMANOVA 1.1e-11
p.adjustMANOVA 2.85e-10
s.dist 0.555
s.bl 0.386
s.gu 0.399
p.bl 5.83e-08
p.gu 2.02e-08



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
CAPNS1 2180.0 5486.0
C1QBP 2600.0 4528.0
CASP8 1965.0 4768.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
PRIM1 1900.0 4123.0
H2BC26 1094.0 5119.0
H2BC15 1691.0 2415.0
RBBP4 1101.0 3128.0
H2BC9 3001.5 1112.5
CDKN2A 748.0 2636.0

Click HERE to show all gene set members

All member genes
bl gu
APP -12539.0 -3920.0
BCL2L11 -8865.0 -2266.0
C1QBP 2600.0 4528.0
CAPN1 -9260.0 4725.0
CAPN2 -7158.0 -5399.0
CAPNS1 2180.0 5486.0
CAPNS2 -109.0 2833.0
CASP8 1965.0 4768.0
CAST -10020.0 -68.0
CDC25A -3962.0 -545.0
CDC25B 1157.0 -11602.0
CDC25C -717.0 -6073.0
CDK5 1356.0 948.0
CDK5R1 -6343.0 -4692.0
CDKN2A 748.0 2636.0
DNMT1 -10941.0 -6087.0
DNMT3A -12498.0 -1582.0
DNMT3B -15370.0 -1653.0
EED -6315.0 3767.0
EZH2 -16231.0 -760.0
FADD -5927.0 1536.0
FASLG 3029.0 -15296.0
FOXO3 -11273.0 -3259.0
GOLGA2 -3804.0 6310.0
GSDME -10038.0 -1079.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
JUN -100.0 -2472.0
LMNA -7388.0 3244.0
LMNB1 -10737.0 -637.0
MLKL -1022.0 1120.0
POLA2 -382.0 2365.0
PRDX1 -5537.0 -3945.0
PRDX2 -9006.0 -1290.0
PRIM1 1900.0 4123.0
PRIM2 -5090.0 -7881.0
RBBP4 1101.0 3128.0
RIPK1 -11102.0 -5780.0
RIPK3 -7079.0 5335.0
SOD2 201.0 -9952.0
SUZ12 -18160.0 3473.0
TP53 -1908.0 -1792.0
TRADD -2482.0 1233.0
TRAF2 -2587.0 4673.0
YWHAE -4903.0 -367.0



Assembly of the pre-replicative complex
Assembly of the pre-replicative complex
metric value
setSize 105
pMANOVA 3.92e-18
p.adjustMANOVA 2.66e-16
s.dist 0.555
s.bl 0.382
s.gu 0.403
p.bl 1.37e-11
p.gu 9.34e-13



Top 20 genes
Gene bl gu
H2AC7 3223.5 6529.5
H2BC5 3193.0 6363.0
H4C1 3228.0 5997.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2BC4 3170.0 5560.0
H2BC13 2215.0 6322.0
H2BC3 2331.0 5881.0
H2BC21 2156.0 5596.0
PSMC2 2039.0 5911.0
RPS27A 2474.0 4870.0
ANAPC10 1889.0 6216.0
PSMA5 2124.0 5492.0
UBB 2897.0 3835.0
H2AC14 3419.0 2680.0
H2BC14 3386.0 2412.0
PSME1 1258.0 6258.0
PSMD7 1938.0 3921.0
PSMD3 1296.0 5115.0
H2BC26 1094.0 5119.0

Click HERE to show all gene set members

All member genes
bl gu
ANAPC1 920.0 3151.0
ANAPC10 1889.0 6216.0
ANAPC11 -209.0 206.0
ANAPC15 -348.0 4476.0
ANAPC16 -4019.0 4909.0
ANAPC2 -7946.0 3718.0
ANAPC4 -11522.0 -5185.0
ANAPC5 -12364.0 3458.0
ANAPC7 427.0 1604.0
CDC16 -3440.0 -1814.0
CDC23 1842.0 -10239.0
CDC26 -3595.0 4573.0
CDC27 -15650.0 -11665.0
CDC6 -8907.0 772.0
CDT1 -9541.0 -11285.0
FZR1 -13711.0 4744.0
GMNN 451.0 4907.0
H2AC14 3419.0 2680.0
H2AC18 2344.5 -14692.5
H2AC20 -5983.0 6432.0
H2AC4 2791.0 6470.0
H2AC6 2777.0 6468.0
H2AC7 3223.5 6529.5
H2AJ -7123.0 -466.0
H2AZ2 -6348.0 -3330.0
H2BC1 -17133.0 -10310.0
H2BC11 1468.0 -7008.0
H2BC12 -327.0 -8473.0
H2BC13 2215.0 6322.0
H2BC14 3386.0 2412.0
H2BC15 1691.0 2415.0
H2BC17 -1171.0 6518.0
H2BC21 2156.0 5596.0
H2BC26 1094.0 5119.0
H2BC3 2331.0 5881.0
H2BC4 3170.0 5560.0
H2BC5 3193.0 6363.0
H2BC9 3001.5 1112.5
H3-3A -3252.0 -2939.0
H4C1 3228.0 5997.0
KPNA1 -14970.0 -1899.0
KPNA6 -6639.0 4126.0
KPNB1 2029.0 -128.0
MCM2 -13361.0 4134.0
MCM3 -1286.0 3066.0
MCM4 -412.0 -5257.0
MCM5 -4327.0 1149.0
MCM6 -2608.0 -11117.0
MCM7 -10503.0 2085.0
MCM8 -10896.0 338.0
ORC1 -4165.0 4487.0
ORC2 -11476.0 -7345.0
ORC3 -9469.0 2115.0
ORC4 -15664.0 -2229.0
ORC5 -15725.0 -5092.0
ORC6 549.0 2795.0
PSMA1 -5786.0 3356.0
PSMA2 1536.0 -10732.0
PSMA3 810.0 3820.0
PSMA4 329.0 3030.0
PSMA5 2124.0 5492.0
PSMA6 -1232.0 5113.0
PSMA7 -1156.0 5681.0
PSMB1 845.0 -3582.0
PSMB10 -3130.0 2949.0
PSMB2 -1534.0 1235.0
PSMB3 -643.0 -5438.0
PSMB4 -9183.0 -11551.0
PSMB5 -3416.0 -1886.0
PSMB6 -3671.0 -9313.0
PSMB7 -4904.0 5390.0
PSMB8 -1072.0 -4426.0
PSMB9 447.0 -5314.0
PSMC1 160.0 -7293.0
PSMC2 2039.0 5911.0
PSMC3 -790.0 -4525.0
PSMC4 2755.0 -1268.0
PSMC5 -7133.0 -1777.0
PSMC6 -8882.0 3826.0
PSMD1 -16767.0 -8987.0
PSMD11 -888.0 2009.0
PSMD12 1861.0 -8762.0
PSMD13 -2968.0 3872.0
PSMD14 -16183.0 -4192.0
PSMD2 -3521.0 -2077.0
PSMD3 1296.0 5115.0
PSMD4 -2291.0 -1907.0
PSMD5 -214.0 -510.0
PSMD6 -14806.0 -9379.0
PSMD7 1938.0 3921.0
PSMD8 -10728.0 2096.0
PSMD9 -3140.0 34.0
PSME1 1258.0 6258.0
PSME2 3.0 227.0
PSME3 1771.0 77.0
PSMF1 -7191.0 -2062.0
RPS27A 2474.0 4870.0
SEM1 -15434.0 -1185.0
UBA52 -1335.0 2310.0
UBB 2897.0 3835.0
UBC -1239.0 364.0
UBE2C 121.0 -2231.0
UBE2D1 -9408.0 1824.0
UBE2E1 -11525.0 325.0
UBE2S -9680.0 4625.0



Peptide chain elongation
Peptide chain elongation
metric value
setSize 84
pMANOVA 3.13e-15
p.adjustMANOVA 1.46e-13
s.dist 0.554
s.bl 0.488
s.gu 0.262
p.bl 9.66e-15
p.gu 3.19e-05



Top 20 genes
Gene bl gu
RPS17 3433 4407
RPL35 1927 6578
RPL34 2689 4514
RPS27A 2474 4870
RPL35A 2785 4084
RPS19 2467 4525
RPL41 2706 3666
EEF1A1 1341 5960
RPL23 2084 3617
RPS27 1007 5691
RPL7 863 5284
RPL27A 1408 2302
RPL28 2435 1189
RPS23 1310 2106
RPSA 417 6081
RPS16 546 3749
RPS18 772 1775
RPS8 54 4142
RPS3 96 1863

Click HERE to show all gene set members

All member genes
bl gu
EEF1A1 1341.0 5960.0
EEF2 -10382.0 -1129.0
FAU 501.0 -9349.0
RPL10A -2013.0 4685.0
RPL10L -17670.0 5711.0
RPL11 -8037.0 -2061.0
RPL12 -130.0 1503.0
RPL13 -1548.0 -5574.0
RPL13A -4052.5 -9633.5
RPL14 1631.0 -5484.0
RPL15 250.0 -251.0
RPL17 -4437.0 -13234.0
RPL18 876.0 -1169.0
RPL18A -1317.0 -11710.0
RPL19 -8003.0 -3333.0
RPL21 -4376.0 1198.0
RPL22 -3975.0 -10581.0
RPL22L1 -9083.0 -12129.0
RPL23 2084.0 3617.0
RPL23A -773.0 1666.0
RPL24 -2235.0 5267.0
RPL26 -2956.0 4317.0
RPL26L1 -3209.0 -6118.0
RPL27 132.0 -8051.0
RPL27A 1408.0 2302.0
RPL28 2435.0 1189.0
RPL29 -815.0 -8220.0
RPL3 -3336.0 4801.0
RPL30 81.0 -3580.0
RPL31 -7339.0 2524.0
RPL32 2380.0 -6560.0
RPL34 2689.0 4514.0
RPL35 1927.0 6578.0
RPL35A 2785.0 4084.0
RPL36 -912.0 4044.0
RPL36AL -1366.0 -673.0
RPL37 -3865.0 -7333.0
RPL37A -3530.0 5135.0
RPL38 -12385.0 3878.0
RPL39L 2142.0 -3518.0
RPL3L -8236.0 -14786.0
RPL4 2479.0 -3514.0
RPL41 2706.0 3666.0
RPL5 -4507.0 -6166.0
RPL6 -14772.0 1510.0
RPL7 863.0 5284.0
RPL7A 485.0 -3611.0
RPL8 -1269.0 -1974.0
RPL9 -3338.0 2752.0
RPLP0 -222.0 -5055.0
RPLP1 -10495.0 -5762.0
RPLP2 1668.0 -8086.0
RPS10 -3720.0 1709.0
RPS11 2174.0 -12139.0
RPS12 2996.0 -779.0
RPS13 -3689.0 -12947.0
RPS14 -8441.0 6040.0
RPS15 -3429.0 2966.0
RPS15A -3309.0 2257.0
RPS16 546.0 3749.0
RPS17 3433.0 4407.0
RPS18 772.0 1775.0
RPS19 2467.0 4525.0
RPS2 213.0 -11527.0
RPS20 -1332.0 -4105.0
RPS21 -78.0 -5475.0
RPS23 1310.0 2106.0
RPS24 -5323.0 5191.0
RPS25 -826.0 -1722.0
RPS26 -3319.0 5742.0
RPS27 1007.0 5691.0
RPS27A 2474.0 4870.0
RPS27L 670.0 -6194.0
RPS28 -12426.0 -3732.0
RPS29 1038.0 -11031.0
RPS3 96.0 1863.0
RPS3A -742.0 -2566.0
RPS5 -9328.0 -13724.0
RPS6 -9787.0 449.0
RPS7 -4504.0 -4285.0
RPS8 54.0 4142.0
RPS9 -6281.0 -7716.0
RPSA 417.0 6081.0
UBA52 -1335.0 2310.0



Eukaryotic Translation Termination
Eukaryotic Translation Termination
metric value
setSize 87
pMANOVA 1.05e-15
p.adjustMANOVA 5.53e-14
s.dist 0.553
s.bl 0.49
s.gu 0.256
p.bl 2.69e-15
p.gu 3.64e-05



Top 20 genes
Gene bl gu
RPS17 3433 4407
RPL35 1927 6578
RPL34 2689 4514
RPS27A 2474 4870
RPL35A 2785 4084
RPS19 2467 4525
RPL41 2706 3666
RPL23 2084 3617
RPS27 1007 5691
RPL7 863 5284
RPL27A 1408 2302
RPL28 2435 1189
RPS23 1310 2106
RPSA 417 6081
RPS16 546 3749
RPS18 772 1775
RPS8 54 4142
RPS3 96 1863

Click HERE to show all gene set members

All member genes
bl gu
APEH -6264.0 1540.0
ETF1 -1681.0 -10143.0
FAU 501.0 -9349.0
GSPT1 -4769.0 1548.0
N6AMT1 917.0 -3488.0
RPL10A -2013.0 4685.0
RPL10L -17670.0 5711.0
RPL11 -8037.0 -2061.0
RPL12 -130.0 1503.0
RPL13 -1548.0 -5574.0
RPL13A -4052.5 -9633.5
RPL14 1631.0 -5484.0
RPL15 250.0 -251.0
RPL17 -4437.0 -13234.0
RPL18 876.0 -1169.0
RPL18A -1317.0 -11710.0
RPL19 -8003.0 -3333.0
RPL21 -4376.0 1198.0
RPL22 -3975.0 -10581.0
RPL22L1 -9083.0 -12129.0
RPL23 2084.0 3617.0
RPL23A -773.0 1666.0
RPL24 -2235.0 5267.0
RPL26 -2956.0 4317.0
RPL26L1 -3209.0 -6118.0
RPL27 132.0 -8051.0
RPL27A 1408.0 2302.0
RPL28 2435.0 1189.0
RPL29 -815.0 -8220.0
RPL3 -3336.0 4801.0
RPL30 81.0 -3580.0
RPL31 -7339.0 2524.0
RPL32 2380.0 -6560.0
RPL34 2689.0 4514.0
RPL35 1927.0 6578.0
RPL35A 2785.0 4084.0
RPL36 -912.0 4044.0
RPL36AL -1366.0 -673.0
RPL37 -3865.0 -7333.0
RPL37A -3530.0 5135.0
RPL38 -12385.0 3878.0
RPL39L 2142.0 -3518.0
RPL3L -8236.0 -14786.0
RPL4 2479.0 -3514.0
RPL41 2706.0 3666.0
RPL5 -4507.0 -6166.0
RPL6 -14772.0 1510.0
RPL7 863.0 5284.0
RPL7A 485.0 -3611.0
RPL8 -1269.0 -1974.0
RPL9 -3338.0 2752.0
RPLP0 -222.0 -5055.0
RPLP1 -10495.0 -5762.0
RPLP2 1668.0 -8086.0
RPS10 -3720.0 1709.0
RPS11 2174.0 -12139.0
RPS12 2996.0 -779.0
RPS13 -3689.0 -12947.0
RPS14 -8441.0 6040.0
RPS15 -3429.0 2966.0
RPS15A -3309.0 2257.0
RPS16 546.0 3749.0
RPS17 3433.0 4407.0
RPS18 772.0 1775.0
RPS19 2467.0 4525.0
RPS2 213.0 -11527.0
RPS20 -1332.0 -4105.0
RPS21 -78.0 -5475.0
RPS23 1310.0 2106.0
RPS24 -5323.0 5191.0
RPS25 -826.0 -1722.0
RPS26 -3319.0 5742.0
RPS27 1007.0 5691.0
RPS27A 2474.0 4870.0
RPS27L 670.0 -6194.0
RPS28 -12426.0 -3732.0
RPS29 1038.0 -11031.0
RPS3 96.0 1863.0
RPS3A -742.0 -2566.0
RPS5 -9328.0 -13724.0
RPS6 -9787.0 449.0
RPS7 -4504.0 -4285.0
RPS8 54.0 4142.0
RPS9 -6281.0 -7716.0
RPSA 417.0 6081.0
TRMT112 -2566.0 4684.0
UBA52 -1335.0 2310.0



SCF(Skp2)-mediated degradation of p27/p21
SCF(Skp2)-mediated degradation of p27/p21
metric value
setSize 59
pMANOVA 2.95e-10
p.adjustMANOVA 5.8e-09
s.dist 0.547
s.bl 0.417
s.gu 0.353
p.bl 2.9e-08
p.gu 2.71e-06



Top 20 genes
Gene bl gu
PSMC2 2039 5911
RPS27A 2474 4870
PSMA5 2124 5492
UBB 2897 3835
PSME1 1258 6258
PSMD7 1938 3921
CDK4 1624 4652
PSMD3 1296 5115
CKS1B 1777 3570
PSMA3 810 3820
SKP1 1137 1304
PSMA4 329 3030
PSME3 1771 77
PSME2 3 227

Click HERE to show all gene set members

All member genes
bl gu
CCNA1 -6749 -5180
CCNA2 -415 362
CCND1 -11030 672
CCNE1 -11404 -3150
CCNE2 -339 5928
CDK2 -9336 -1131
CDK4 1624 4652
CDKN1A -3477 5305
CDKN1B -344 -942
CKS1B 1777 3570
CUL1 -10249 -2896
PSMA1 -5786 3356
PSMA2 1536 -10732
PSMA3 810 3820
PSMA4 329 3030
PSMA5 2124 5492
PSMA6 -1232 5113
PSMA7 -1156 5681
PSMB1 845 -3582
PSMB10 -3130 2949
PSMB2 -1534 1235
PSMB3 -643 -5438
PSMB4 -9183 -11551
PSMB5 -3416 -1886
PSMB6 -3671 -9313
PSMB7 -4904 5390
PSMB8 -1072 -4426
PSMB9 447 -5314
PSMC1 160 -7293
PSMC2 2039 5911
PSMC3 -790 -4525
PSMC4 2755 -1268
PSMC5 -7133 -1777
PSMC6 -8882 3826
PSMD1 -16767 -8987
PSMD11 -888 2009
PSMD12 1861 -8762
PSMD13 -2968 3872
PSMD14 -16183 -4192
PSMD2 -3521 -2077
PSMD3 1296 5115
PSMD4 -2291 -1907
PSMD5 -214 -510
PSMD6 -14806 -9379
PSMD7 1938 3921
PSMD8 -10728 2096
PSMD9 -3140 34
PSME1 1258 6258
PSME2 3 227
PSME3 1771 77
PSMF1 -7191 -2062
PTK6 -4096 -12468
RPS27A 2474 4870
SEM1 -15434 -1185
SKP1 1137 1304
SKP2 -579 1405
UBA52 -1335 2310
UBB 2897 3835
UBC -1239 364



TICAM1,TRAF6-dependent induction of TAK1 complex
TICAM1,TRAF6-dependent induction of TAK1 complex
metric value
setSize 10
pMANOVA 0.024
p.adjustMANOVA 0.0708
s.dist 0.547
s.bl 0.421
s.gu 0.348
p.bl 0.021
p.gu 0.0566



Top 20 genes
Gene bl gu
TLR3 2913 4674
RPS27A 2474 4870
UBB 2897 3835

Click HERE to show all gene set members

All member genes
bl gu
MAP3K7 -6681 -9739
RPS27A 2474 4870
TAB1 -9338 2628
TAB2 -9842 -9002
TICAM1 -363 -281
TLR3 2913 4674
TRAF6 -9131 -4858
UBA52 -1335 2310
UBB 2897 3835
UBC -1239 364



Formation of ATP by chemiosmotic coupling
Formation of ATP by chemiosmotic coupling
metric value
setSize 18
pMANOVA 0.00126
p.adjustMANOVA 0.00562
s.dist 0.547
s.bl 0.385
s.gu 0.388
p.bl 0.0047
p.gu 0.00436



Top 20 genes
Gene bl gu
ATP5MG 1600 3233
ATP5PD 1185 4092

Click HERE to show all gene set members

All member genes
bl gu
ATP5F1A 2323 -11073
ATP5F1B -2276 5087
ATP5F1C -7602 -7320
ATP5F1D -2440 2177
ATP5F1E -956 4924
ATP5MC1 324 -556
ATP5MC2 -9026 3858
ATP5MC3 -1297 -14367
ATP5ME -10905 -1
ATP5MF -2641 -227
ATP5MG 1600 3233
ATP5MJ -3806 2856
ATP5MK -2223 4766
ATP5PB -11082 -590
ATP5PD 1185 4092
ATP5PF -368 4529
ATP5PO -4639 873
DMAC2L -6898 -3637



Glucuronidation
Glucuronidation
metric value
setSize 24
pMANOVA 0.000139
p.adjustMANOVA 0.000763
s.dist 0.545
s.bl -0.357
s.gu -0.412
p.bl 0.00245
p.gu 0.000477



Top 20 genes
Gene bl gu
UGT2B11 -18603 -15239
UGT2B4 -18589 -15004
UGT2B7 -17253 -14894
UGT2B10 -18572 -13737
UGT2B28 -18755 -13229
UGT2A1 -18128 -10203
UGT2A3 -18186 -8904
UGT1A1 -9776 -14878
UGT1A8 -11275 -12071
UGT1A10 -10952 -12246
UGT1A7 -10558 -11542
SLC35D1 -14395 -8366
UGT2B15 -11926 -9929
UGT1A9 -9584 -12116
UGT1A6 -8439 -12223
UGT1A5 -8363 -10912
UGT1A3 -7812 -11561
UGT1A4 -7598 -9869
UGDH -5360 -4690
UGP2 -6939 -835

Click HERE to show all gene set members

All member genes
bl gu
ABHD10 222 2781
SLC35D1 -14395 -8366
UGDH -5360 -4690
UGP2 -6939 -835
UGT1A1 -9776 -14878
UGT1A10 -10952 -12246
UGT1A3 -7812 -11561
UGT1A4 -7598 -9869
UGT1A5 -8363 -10912
UGT1A6 -8439 -12223
UGT1A7 -10558 -11542
UGT1A8 -11275 -12071
UGT1A9 -9584 -12116
UGT2A1 -18128 -10203
UGT2A3 -18186 -8904
UGT2B10 -18572 -13737
UGT2B11 -18603 -15239
UGT2B15 -11926 -9929
UGT2B17 -18335 1482
UGT2B28 -18755 -13229
UGT2B4 -18589 -15004
UGT2B7 -17253 -14894
UGT3A1 -1050 -2838
UGT3A2 -8839 5617



TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
metric value
setSize 11
pMANOVA 0.0162
p.adjustMANOVA 0.0506
s.dist 0.544
s.bl 0.452
s.gu 0.303
p.bl 0.00944
p.gu 0.0819



Top 20 genes
Gene bl gu
RPS27A 2474 4870
UBB 2897 3835

Click HERE to show all gene set members

All member genes
bl gu
IRAK4 -8542 -9871
IRF7 -2273 2749
MYD88 2481 -2824
RPS27A 2474 4870
TLR9 -10795 -6924
TRAF6 -9131 -4858
UBA52 -1335 2310
UBB 2897 3835
UBC -1239 364
UBE2N -1608 -6247
UBE2V1 -1806 5345



Sensory perception of taste
Sensory perception of taste
metric value
setSize 47
pMANOVA 3.47e-08
p.adjustMANOVA 4.01e-07
s.dist 0.543
s.bl -0.383
s.gu -0.385
p.bl 5.68e-06
p.gu 4.91e-06



Top 20 genes
Gene bl gu
TAS2R43 -17856 -15392
GNAT3 -18381 -14664
TAS2R39 -18435 -14596
TAS2R1 -18100 -14766
TAS2R3 -18482 -14363
TAS2R20 -18429 -14250
TAS2R30 -17943 -14511
TAS2R50 -18497 -13978
TAS2R10 -18424 -13961
TAS2R8 -18332 -13704
TAS2R14 -18072 -13336
TAS2R41 -16568 -13775
TAS2R16 -15798 -13703
TAS2R7 -18030 -12000
TAS2R4 -11890 -15336
TAS2R5 -16147 -9902
TAS2R46 -18171 -8572
GRM1 -14284 -10788
SCN1B -14370 -10242
SCN9A -13814 -9919

Click HERE to show all gene set members

All member genes
bl gu
CALHM1 -11267 -5599
CALHM3 -11738 -11535
GNAT3 -18381 -14664
GNB1 -14809 -3010
GNB3 -11468 5124
GNG13 -4194 28
GRM1 -14284 -10788
GRM4 -4486 -7923
ITPR3 -10289 -11406
KCNJ2 -11017 -9537
OTOP1 296 -15177
PLCB2 -12756 -7112
SCN1B -14370 -10242
SCN2A -9740 -10416
SCN2B -8208 -650
SCN3A -9780 -8730
SCN4B -5614 -4956
SCN9A -13814 -9919
SCNN1A -9167 -10670
SCNN1B 641 -5752
SCNN1D -5718 -11807
SCNN1G -1247 -1873
TAS1R1 -2485 -10194
TAS1R2 -2101 3661
TAS1R3 -8648 3952
TAS2R1 -18100 -14766
TAS2R10 -18424 -13961
TAS2R13 -16324 4148
TAS2R14 -18072 -13336
TAS2R16 -15798 -13703
TAS2R20 -18429 -14250
TAS2R3 -18482 -14363
TAS2R30 -17943 -14511
TAS2R31 -17684 -3837
TAS2R38 -7460 -10264
TAS2R39 -18435 -14596
TAS2R4 -11890 -15336
TAS2R40 -16226 1373
TAS2R41 -16568 -13775
TAS2R43 -17856 -15392
TAS2R46 -18171 -8572
TAS2R5 -16147 -9902
TAS2R50 -18497 -13978
TAS2R7 -18030 -12000
TAS2R8 -18332 -13704
TRPM4 -4963 -9369
TRPM5 -3066 -4322



Eukaryotic Translation Elongation
Eukaryotic Translation Elongation
metric value
setSize 88
pMANOVA 2.96e-15
p.adjustMANOVA 1.42e-13
s.dist 0.54
s.bl 0.482
s.gu 0.244
p.bl 5.25e-15
p.gu 7.38e-05



Top 20 genes
Gene bl gu
RPS17 3433 4407
RPL35 1927 6578
RPL34 2689 4514
RPS27A 2474 4870
RPL35A 2785 4084
RPS19 2467 4525
RPL41 2706 3666
EEF1A1 1341 5960
RPL23 2084 3617
RPS27 1007 5691
RPL7 863 5284
RPL27A 1408 2302
RPL28 2435 1189
RPS23 1310 2106
RPSA 417 6081
RPS16 546 3749
RPS18 772 1775
RPS8 54 4142
RPS3 96 1863

Click HERE to show all gene set members

All member genes
bl gu
EEF1A1 1341.0 5960.0
EEF1A2 -7898.0 -9876.0
EEF1B2 2767.0 -1277.0
EEF1D -9065.0 -11975.0
EEF1G -1124.0 -495.0
EEF2 -10382.0 -1129.0
FAU 501.0 -9349.0
RPL10A -2013.0 4685.0
RPL10L -17670.0 5711.0
RPL11 -8037.0 -2061.0
RPL12 -130.0 1503.0
RPL13 -1548.0 -5574.0
RPL13A -4052.5 -9633.5
RPL14 1631.0 -5484.0
RPL15 250.0 -251.0
RPL17 -4437.0 -13234.0
RPL18 876.0 -1169.0
RPL18A -1317.0 -11710.0
RPL19 -8003.0 -3333.0
RPL21 -4376.0 1198.0
RPL22 -3975.0 -10581.0
RPL22L1 -9083.0 -12129.0
RPL23 2084.0 3617.0
RPL23A -773.0 1666.0
RPL24 -2235.0 5267.0
RPL26 -2956.0 4317.0
RPL26L1 -3209.0 -6118.0
RPL27 132.0 -8051.0
RPL27A 1408.0 2302.0
RPL28 2435.0 1189.0
RPL29 -815.0 -8220.0
RPL3 -3336.0 4801.0
RPL30 81.0 -3580.0
RPL31 -7339.0 2524.0
RPL32 2380.0 -6560.0
RPL34 2689.0 4514.0
RPL35 1927.0 6578.0
RPL35A 2785.0 4084.0
RPL36 -912.0 4044.0
RPL36AL -1366.0 -673.0
RPL37 -3865.0 -7333.0
RPL37A -3530.0 5135.0
RPL38 -12385.0 3878.0
RPL39L 2142.0 -3518.0
RPL3L -8236.0 -14786.0
RPL4 2479.0 -3514.0
RPL41 2706.0 3666.0
RPL5 -4507.0 -6166.0
RPL6 -14772.0 1510.0
RPL7 863.0 5284.0
RPL7A 485.0 -3611.0
RPL8 -1269.0 -1974.0
RPL9 -3338.0 2752.0
RPLP0 -222.0 -5055.0
RPLP1 -10495.0 -5762.0
RPLP2 1668.0 -8086.0
RPS10 -3720.0 1709.0
RPS11 2174.0 -12139.0
RPS12 2996.0 -779.0
RPS13 -3689.0 -12947.0
RPS14 -8441.0 6040.0
RPS15 -3429.0 2966.0
RPS15A -3309.0 2257.0
RPS16 546.0 3749.0
RPS17 3433.0 4407.0
RPS18 772.0 1775.0
RPS19 2467.0 4525.0
RPS2 213.0 -11527.0
RPS20 -1332.0 -4105.0
RPS21 -78.0 -5475.0
RPS23 1310.0 2106.0
RPS24 -5323.0 5191.0
RPS25 -826.0 -1722.0
RPS26 -3319.0 5742.0
RPS27 1007.0 5691.0
RPS27A 2474.0 4870.0
RPS27L 670.0 -6194.0
RPS28 -12426.0 -3732.0
RPS29 1038.0 -11031.0
RPS3 96.0 1863.0
RPS3A -742.0 -2566.0
RPS5 -9328.0 -13724.0
RPS6 -9787.0 449.0
RPS7 -4504.0 -4285.0
RPS8 54.0 4142.0
RPS9 -6281.0 -7716.0
RPSA 417.0 6081.0
UBA52 -1335.0 2310.0



GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
metric value
setSize 51
pMANOVA 1.08e-08
p.adjustMANOVA 1.46e-07
s.dist 0.537
s.bl 0.412
s.gu 0.345
p.bl 3.61e-07
p.gu 1.97e-05



Top 20 genes
Gene bl gu
PSMC2 2039 5911
RPS27A 2474 4870
PSMA5 2124 5492
UBB 2897 3835
PSME1 1258 6258
PSMD7 1938 3921
PSMD3 1296 5115
PSMA3 810 3820
SKP1 1137 1304
PSMA4 329 3030
PSME3 1771 77
PSME2 3 227

Click HERE to show all gene set members

All member genes
bl gu
BTRC -16135 20
CUL1 -10249 -2896
GSK3B -5010 -11030
NFE2L2 -1484 4174
PSMA1 -5786 3356
PSMA2 1536 -10732
PSMA3 810 3820
PSMA4 329 3030
PSMA5 2124 5492
PSMA6 -1232 5113
PSMA7 -1156 5681
PSMB1 845 -3582
PSMB10 -3130 2949
PSMB2 -1534 1235
PSMB3 -643 -5438
PSMB4 -9183 -11551
PSMB5 -3416 -1886
PSMB6 -3671 -9313
PSMB7 -4904 5390
PSMB8 -1072 -4426
PSMB9 447 -5314
PSMC1 160 -7293
PSMC2 2039 5911
PSMC3 -790 -4525
PSMC4 2755 -1268
PSMC5 -7133 -1777
PSMC6 -8882 3826
PSMD1 -16767 -8987
PSMD11 -888 2009
PSMD12 1861 -8762
PSMD13 -2968 3872
PSMD14 -16183 -4192
PSMD2 -3521 -2077
PSMD3 1296 5115
PSMD4 -2291 -1907
PSMD5 -214 -510
PSMD6 -14806 -9379
PSMD7 1938 3921
PSMD8 -10728 2096
PSMD9 -3140 34
PSME1 1258 6258
PSME2 3 227
PSME3 1771 77
PSMF1 -7191 -2062
RBX1 -696 5396
RPS27A 2474 4870
SEM1 -15434 -1185
SKP1 1137 1304
UBA52 -1335 2310
UBB 2897 3835
UBC -1239 364



Viral mRNA Translation
Viral mRNA Translation
metric value
setSize 84
pMANOVA 3.03e-14
p.adjustMANOVA 1.18e-12
s.dist 0.536
s.bl 0.469
s.gu 0.259
p.bl 9.91e-14
p.gu 4.06e-05



Top 20 genes
Gene bl gu
RPS17 3433 4407
RPL35 1927 6578
RPL34 2689 4514
RPS27A 2474 4870
RPL35A 2785 4084
RPS19 2467 4525
RPL41 2706 3666
RPL23 2084 3617
RPS27 1007 5691
RPL7 863 5284
RPL27A 1408 2302
RPL28 2435 1189
RPS23 1310 2106
RPSA 417 6081
RPS16 546 3749
RPS18 772 1775
RPS8 54 4142
RPS3 96 1863

Click HERE to show all gene set members

All member genes
bl gu
DNAJC3 -14517.0 -733.0
FAU 501.0 -9349.0
GRSF1 -12220.0 2303.0
RPL10A -2013.0 4685.0
RPL10L -17670.0 5711.0
RPL11 -8037.0 -2061.0
RPL12 -130.0 1503.0
RPL13 -1548.0 -5574.0
RPL13A -4052.5 -9633.5
RPL14 1631.0 -5484.0
RPL15 250.0 -251.0
RPL17 -4437.0 -13234.0
RPL18 876.0 -1169.0
RPL18A -1317.0 -11710.0
RPL19 -8003.0 -3333.0
RPL21 -4376.0 1198.0
RPL22 -3975.0 -10581.0
RPL22L1 -9083.0 -12129.0
RPL23 2084.0 3617.0
RPL23A -773.0 1666.0
RPL24 -2235.0 5267.0
RPL26 -2956.0 4317.0
RPL26L1 -3209.0 -6118.0
RPL27 132.0 -8051.0
RPL27A 1408.0 2302.0
RPL28 2435.0 1189.0
RPL29 -815.0 -8220.0
RPL3 -3336.0 4801.0
RPL30 81.0 -3580.0
RPL31 -7339.0 2524.0
RPL32 2380.0 -6560.0
RPL34 2689.0 4514.0
RPL35 1927.0 6578.0
RPL35A 2785.0 4084.0
RPL36 -912.0 4044.0
RPL36AL -1366.0 -673.0
RPL37 -3865.0 -7333.0
RPL37A -3530.0 5135.0
RPL38 -12385.0 3878.0
RPL39L 2142.0 -3518.0
RPL3L -8236.0 -14786.0
RPL4 2479.0 -3514.0
RPL41 2706.0 3666.0
RPL5 -4507.0 -6166.0
RPL6 -14772.0 1510.0
RPL7 863.0 5284.0
RPL7A 485.0 -3611.0
RPL8 -1269.0 -1974.0
RPL9 -3338.0 2752.0
RPLP0 -222.0 -5055.0
RPLP1 -10495.0 -5762.0
RPLP2 1668.0 -8086.0
RPS10 -3720.0 1709.0
RPS11 2174.0 -12139.0
RPS12 2996.0 -779.0
RPS13 -3689.0 -12947.0
RPS14 -8441.0 6040.0
RPS15 -3429.0 2966.0
RPS15A -3309.0 2257.0
RPS16 546.0 3749.0
RPS17 3433.0 4407.0
RPS18 772.0 1775.0
RPS19 2467.0 4525.0
RPS2 213.0 -11527.0
RPS20 -1332.0 -4105.0
RPS21 -78.0 -5475.0
RPS23 1310.0 2106.0
RPS24 -5323.0 5191.0
RPS25 -826.0 -1722.0
RPS26 -3319.0 5742.0
RPS27 1007.0 5691.0
RPS27A 2474.0 4870.0
RPS27L 670.0 -6194.0
RPS28 -12426.0 -3732.0
RPS29 1038.0 -11031.0
RPS3 96.0 1863.0
RPS3A -742.0 -2566.0
RPS5 -9328.0 -13724.0
RPS6 -9787.0 449.0
RPS7 -4504.0 -4285.0
RPS8 54.0 4142.0
RPS9 -6281.0 -7716.0
RPSA 417.0 6081.0
UBA52 -1335.0 2310.0



Mitophagy
Mitophagy
metric value
setSize 37
pMANOVA 1.75e-06
p.adjustMANOVA 1.38e-05
s.dist 0.535
s.bl 0.325
s.gu 0.425
p.bl 0.000613
p.gu 7.83e-06



Top 20 genes
Gene bl gu
RPS27A 2474 4870
UBB 2897 3835
TOMM70 1451 3613
UBE2L3 1309 1861
TOMM6 2058 1025

Click HERE to show all gene set members

All member genes
bl gu
ATG12 -6252 -5428
ATG5 -9771 1449
ATG9A -8391 661
CSNK2A1 -5216 887
CSNK2A2 -9153 -1062
CSNK2B -2129 -4326
MAP1LC3A -14093 2289
MAP1LC3B -6219 2469
MFN1 -446 3928
MFN2 -6954 959
MTERF3 -151 1858
OPTN -4563 -7998
PGAM5 -6423 4417
PINK1 -1215 3320
RPS27A 2474 4870
SQSTM1 -3522 -746
SRC -9851 -1342
TBK1 -5573 2895
TOMM20 -4413 -3711
TOMM22 -3414 -1736
TOMM40 -5420 6142
TOMM5 -11317 -1961
TOMM6 2058 1025
TOMM7 -2795 4553
TOMM70 1451 3613
UBA52 -1335 2310
UBB 2897 3835
UBC -1239 364
UBE2D2 -1377 3901
UBE2D3 -3083 -5312
UBE2L3 1309 1861
UBE2N -1608 -6247
UBE2V1 -1806 5345
ULK1 -5468 57
VDAC1 -14399 -1002
VDAC2 -2768 -4433
VDAC3 771 -5678



Selenocysteine synthesis
Selenocysteine synthesis
metric value
setSize 87
pMANOVA 1.3e-14
p.adjustMANOVA 5.42e-13
s.dist 0.533
s.bl 0.47
s.gu 0.25
p.bl 3.2e-14
p.gu 5.46e-05



Top 20 genes
Gene bl gu
RPS17 3433 4407
RPL35 1927 6578
RPL34 2689 4514
RPS27A 2474 4870
RPL35A 2785 4084
RPS19 2467 4525
RPL41 2706 3666
RPL23 2084 3617
RPS27 1007 5691
RPL7 863 5284
RPL27A 1408 2302
RPL28 2435 1189
RPS23 1310 2106
RPSA 417 6081
RPS16 546 3749
RPS18 772 1775
RPS8 54 4142
RPS3 96 1863

Click HERE to show all gene set members

All member genes
bl gu
EEFSEC -10044.0 -6720.0
FAU 501.0 -9349.0
PSTK -8642.0 902.0
RPL10A -2013.0 4685.0
RPL10L -17670.0 5711.0
RPL11 -8037.0 -2061.0
RPL12 -130.0 1503.0
RPL13 -1548.0 -5574.0
RPL13A -4052.5 -9633.5
RPL14 1631.0 -5484.0
RPL15 250.0 -251.0
RPL17 -4437.0 -13234.0
RPL18 876.0 -1169.0
RPL18A -1317.0 -11710.0
RPL19 -8003.0 -3333.0
RPL21 -4376.0 1198.0
RPL22 -3975.0 -10581.0
RPL22L1 -9083.0 -12129.0
RPL23 2084.0 3617.0
RPL23A -773.0 1666.0
RPL24 -2235.0 5267.0
RPL26 -2956.0 4317.0
RPL26L1 -3209.0 -6118.0
RPL27 132.0 -8051.0
RPL27A 1408.0 2302.0
RPL28 2435.0 1189.0
RPL29 -815.0 -8220.0
RPL3 -3336.0 4801.0
RPL30 81.0 -3580.0
RPL31 -7339.0 2524.0
RPL32 2380.0 -6560.0
RPL34 2689.0 4514.0
RPL35 1927.0 6578.0
RPL35A 2785.0 4084.0
RPL36 -912.0 4044.0
RPL36AL -1366.0 -673.0
RPL37 -3865.0 -7333.0
RPL37A -3530.0 5135.0
RPL38 -12385.0 3878.0
RPL39L 2142.0 -3518.0
RPL3L -8236.0 -14786.0
RPL4 2479.0 -3514.0
RPL41 2706.0 3666.0
RPL5 -4507.0 -6166.0
RPL6 -14772.0 1510.0
RPL7 863.0 5284.0
RPL7A 485.0 -3611.0
RPL8 -1269.0 -1974.0
RPL9 -3338.0 2752.0
RPLP0 -222.0 -5055.0
RPLP1 -10495.0 -5762.0
RPLP2 1668.0 -8086.0
RPS10 -3720.0 1709.0
RPS11 2174.0 -12139.0
RPS12 2996.0 -779.0
RPS13 -3689.0 -12947.0
RPS14 -8441.0 6040.0
RPS15 -3429.0 2966.0
RPS15A -3309.0 2257.0
RPS16 546.0 3749.0
RPS17 3433.0 4407.0
RPS18 772.0 1775.0
RPS19 2467.0 4525.0
RPS2 213.0 -11527.0
RPS20 -1332.0 -4105.0
RPS21 -78.0 -5475.0
RPS23 1310.0 2106.0
RPS24 -5323.0 5191.0
RPS25 -826.0 -1722.0
RPS26 -3319.0 5742.0
RPS27 1007.0 5691.0
RPS27A 2474.0 4870.0
RPS27L 670.0 -6194.0
RPS28 -12426.0 -3732.0
RPS29 1038.0 -11031.0
RPS3 96.0 1863.0
RPS3A -742.0 -2566.0
RPS5 -9328.0 -13724.0
RPS6 -9787.0 449.0
RPS7 -4504.0 -4285.0
RPS8 54.0 4142.0
RPS9 -6281.0 -7716.0
RPSA 417.0 6081.0
SECISBP2 -10726.0 -1638.0
SEPHS2 -2315.0 -5566.0
SEPSECS -1427.0 1553.0
UBA52 -1335.0 2310.0



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    parallel  stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.4                                      
##  [2] GGally_2.2.1                                       
##  [3] ggplot2_3.5.1                                      
##  [4] reshape2_1.4.4                                     
##  [5] beeswarm_0.4.0                                     
##  [6] gplots_3.1.3.1                                     
##  [7] gtools_3.9.5                                       
##  [8] tibble_3.2.1                                       
##  [9] dplyr_1.1.4                                        
## [10] echarts4r_0.4.5                                    
## [11] RhpcBLASctl_0.23-42                                
## [12] eulerr_7.0.2                                       
## [13] kableExtra_1.4.0                                   
## [14] data.table_1.15.4                                  
## [15] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [16] minfi_1.50.0                                       
## [17] bumphunter_1.46.0                                  
## [18] locfit_1.5-9.10                                    
## [19] iterators_1.0.14                                   
## [20] foreach_1.5.2                                      
## [21] Biostrings_2.72.1                                  
## [22] XVector_0.44.0                                     
## [23] SummarizedExperiment_1.34.0                        
## [24] Biobase_2.64.0                                     
## [25] MatrixGenerics_1.16.0                              
## [26] matrixStats_1.3.0                                  
## [27] GenomicRanges_1.56.1                               
## [28] GenomeInfoDb_1.40.1                                
## [29] IRanges_2.38.1                                     
## [30] S4Vectors_0.42.1                                   
## [31] BiocGenerics_0.50.0                                
## [32] HGNChelper_0.8.14                                  
## [33] mitch_1.16.0                                       
## [34] limma_3.60.4                                       
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.4.1             later_1.3.2              
##   [3] BiocIO_1.14.0             bitops_1.0-8             
##   [5] preprocessCore_1.61.0     XML_3.99-0.17            
##   [7] lifecycle_1.0.4           lattice_0.22-6           
##   [9] MASS_7.3-61               base64_2.0.1             
##  [11] scrime_1.3.5              magrittr_2.0.3           
##  [13] sass_0.4.9                rmarkdown_2.27           
##  [15] jquerylib_0.1.4           yaml_2.3.8               
##  [17] httpuv_1.6.15             doRNG_1.8.6              
##  [19] askpass_1.2.0             DBI_1.2.3                
##  [21] RColorBrewer_1.1-3        abind_1.4-5              
##  [23] zlibbioc_1.50.0           quadprog_1.5-8           
##  [25] purrr_1.0.2               RCurl_1.98-1.16          
##  [27] GenomeInfoDbData_1.2.12   genefilter_1.86.0        
##  [29] annotate_1.82.0           svglite_2.1.3            
##  [31] DelayedMatrixStats_1.26.0 codetools_0.2-20         
##  [33] DelayedArray_0.30.1       xml2_1.3.6               
##  [35] tidyselect_1.2.1          farver_2.1.2             
##  [37] UCSC.utils_1.0.0          beanplot_1.3.1           
##  [39] illuminaio_0.46.0         GenomicAlignments_1.40.0 
##  [41] jsonlite_1.8.8            multtest_2.60.0          
##  [43] survival_3.7-0            systemfonts_1.1.0        
##  [45] tools_4.4.1               Rcpp_1.0.12              
##  [47] glue_1.7.0                gridExtra_2.3            
##  [49] SparseArray_1.4.8         xfun_0.45                
##  [51] HDF5Array_1.32.1          withr_3.0.0              
##  [53] fastmap_1.2.0             rhdf5filters_1.16.0      
##  [55] fansi_1.0.6               openssl_2.2.0            
##  [57] caTools_1.18.2            digest_0.6.36            
##  [59] R6_2.5.1                  mime_0.12                
##  [61] colorspace_2.1-1          RSQLite_2.3.7            
##  [63] utf8_1.2.4                tidyr_1.3.1              
##  [65] generics_0.1.3            rtracklayer_1.64.0       
##  [67] httr_1.4.7                htmlwidgets_1.6.4        
##  [69] S4Arrays_1.4.1            ggstats_0.6.0            
##  [71] pkgconfig_2.0.3           gtable_0.3.5             
##  [73] blob_1.2.4                siggenes_1.78.0          
##  [75] htmltools_0.5.8.1         scales_1.3.0             
##  [77] png_0.1-8                 knitr_1.47               
##  [79] rstudioapi_0.16.0         tzdb_0.4.0               
##  [81] rjson_0.2.22              nlme_3.1-165             
##  [83] curl_5.2.1                cachem_1.1.0             
##  [85] rhdf5_2.48.0              stringr_1.5.1            
##  [87] KernSmooth_2.23-24        AnnotationDbi_1.66.0     
##  [89] restfulr_0.0.15           GEOquery_2.72.0          
##  [91] pillar_1.9.0              grid_4.4.1               
##  [93] reshape_0.8.9             vctrs_0.6.5              
##  [95] promises_1.3.0            xtable_1.8-4             
##  [97] evaluate_0.24.0           readr_2.1.5              
##  [99] GenomicFeatures_1.56.0    cli_3.6.3                
## [101] compiler_4.4.1            Rsamtools_2.20.0         
## [103] rlang_1.1.4               crayon_1.5.3             
## [105] rngtools_1.5.2            labeling_0.4.3           
## [107] nor1mix_1.3-3             mclust_6.1.1             
## [109] plyr_1.8.9                stringi_1.8.4            
## [111] viridisLite_0.4.2         BiocParallel_1.38.0      
## [113] munsell_0.5.1             Matrix_1.7-0             
## [115] hms_1.1.3                 sparseMatrixStats_1.16.0 
## [117] bit64_4.0.5               Rhdf5lib_1.26.0          
## [119] KEGGREST_1.44.1           statmod_1.5.0            
## [121] shiny_1.8.1.1             highr_0.11               
## [123] memoise_2.0.1             bslib_0.7.0              
## [125] bit_4.0.5                 splitstackshape_1.4.8

END of report