date generated: 2023-11-14

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
mean
PRDM16 0.6501046
CDH4 0.6997851
SEPT9 0.6428529
KCNQ1 0.5587846
GNAS 0.6544056
SHANK2 0.4526450

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2630
num_genes_in_profile 25739
duplicated_genes_present 0
num_profile_genes_in_sets 10334
num_profile_genes_not_in_sets 15405

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways.gmt
Gene set metrics
Gene sets metrics
num_genesets 2630
num_genesets_excluded 1044
num_genesets_included 1586

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
Chylomicron remodeling 10 2.54e-03 0.551 4.82e-02
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 11 1.65e-03 0.548 3.59e-02
SARS-CoV-1 modulates host translation machinery 34 1.73e-07 0.518 9.79e-06
Josephin domain DUBs 11 5.49e-03 0.483 8.05e-02
TRAF6 mediated IRF7 activation 25 5.09e-05 -0.468 1.72e-03
Class C/3 (Metabotropic glutamate/pheromone receptors) 39 6.08e-07 -0.461 3.33e-05
SUMOylation of immune response proteins 11 8.67e-03 0.457 1.12e-01
Pexophagy 11 8.89e-03 0.455 1.14e-01
Phase 4 - resting membrane potential 19 1.10e-03 0.432 2.77e-02
Interaction With Cumulus Cells And The Zona Pellucida 11 1.43e-02 -0.426 1.55e-01
Regulation of CDH11 gene transcription 10 2.08e-02 0.422 1.90e-01
Expression and translocation of olfactory receptors 358 3.01e-42 -0.418 4.77e-39
NF-kB is activated and signals survival 12 1.25e-02 0.416 1.43e-01
Peptide chain elongation 84 6.63e-11 0.412 1.31e-08
Regulation of NF-kappa B signaling 17 3.41e-03 0.410 5.89e-02
Olfactory Signaling Pathway 365 3.28e-41 -0.409 2.60e-38
Viral mRNA Translation 84 1.32e-10 0.405 2.12e-08
APC/C:Cdc20 mediated degradation of Cyclin B 24 6.62e-04 0.401 1.88e-02
Eukaryotic Translation Termination 87 1.35e-10 0.398 2.12e-08
Eukaryotic Translation Elongation 88 1.47e-10 0.395 2.12e-08
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 2.68e-02 -0.385 2.25e-01
Selenocysteine synthesis 87 1.02e-09 0.378 1.29e-07
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 89 1.18e-09 0.373 1.29e-07
NRIF signals cell death from the nucleus 16 1.00e-02 0.372 1.26e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 10 4.44e-02 0.367 2.96e-01
Intrinsic Pathway of Fibrin Clot Formation 21 3.81e-03 -0.365 6.36e-02
Tandem pore domain potassium channels 12 2.88e-02 0.365 2.36e-01
Regulation of IFNA/IFNB signaling 22 3.31e-03 -0.362 5.84e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency 95 1.17e-09 0.361 1.29e-07
Formation of a pool of free 40S subunits 94 1.71e-09 0.359 1.69e-07
Signaling by cytosolic FGFR1 fusion mutants 17 1.08e-02 -0.357 1.31e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 41 7.68e-05 -0.357 2.44e-03
Pausing and recovery of Tat-mediated HIV elongation 27 1.37e-03 0.356 3.11e-02
Tat-mediated HIV elongation arrest and recovery 27 1.37e-03 0.356 3.11e-02
Caspase activation via Death Receptors in the presence of ligand 16 1.42e-02 -0.354 1.55e-01
p75NTR recruits signalling complexes 12 3.56e-02 0.350 2.58e-01
HIV elongation arrest and recovery 29 1.16e-03 0.348 2.81e-02
Pausing and recovery of HIV elongation 29 1.16e-03 0.348 2.81e-02
Formation of the ternary complex, and subsequently, the 43S complex 46 4.47e-05 0.348 1.58e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 4.67e-02 0.346 2.97e-01
Interleukin-15 signaling 13 3.08e-02 -0.346 2.44e-01
SARS-CoV-2 modulates host translation machinery 46 6.31e-05 0.341 2.04e-03
Selenoamino acid metabolism 103 3.25e-09 0.337 2.72e-07
Attenuation phase 25 3.51e-03 0.337 5.93e-02
Chylomicron assembly 10 6.52e-02 0.337 3.38e-01
L13a-mediated translational silencing of Ceruloplasmin expression 103 4.02e-09 0.335 3.03e-07
GTP hydrolysis and joining of the 60S ribosomal subunit 104 3.93e-09 0.334 3.03e-07
Biosynthesis of DHA-derived SPMs 17 1.73e-02 0.334 1.72e-01
Ribosomal scanning and start codon recognition 53 2.82e-05 0.332 1.09e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 54 2.39e-05 0.332 9.72e-04


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Chylomicron remodeling 10 2.54e-03 0.551000 4.82e-02
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 11 1.65e-03 0.548000 3.59e-02
SARS-CoV-1 modulates host translation machinery 34 1.73e-07 0.518000 9.79e-06
Josephin domain DUBs 11 5.49e-03 0.483000 8.05e-02
TRAF6 mediated IRF7 activation 25 5.09e-05 -0.468000 1.72e-03
Class C/3 (Metabotropic glutamate/pheromone receptors) 39 6.08e-07 -0.461000 3.33e-05
SUMOylation of immune response proteins 11 8.67e-03 0.457000 1.12e-01
Pexophagy 11 8.89e-03 0.455000 1.14e-01
Phase 4 - resting membrane potential 19 1.10e-03 0.432000 2.77e-02
Interaction With Cumulus Cells And The Zona Pellucida 11 1.43e-02 -0.426000 1.55e-01
Regulation of CDH11 gene transcription 10 2.08e-02 0.422000 1.90e-01
Expression and translocation of olfactory receptors 358 3.01e-42 -0.418000 4.77e-39
NF-kB is activated and signals survival 12 1.25e-02 0.416000 1.43e-01
Peptide chain elongation 84 6.63e-11 0.412000 1.31e-08
Regulation of NF-kappa B signaling 17 3.41e-03 0.410000 5.89e-02
Olfactory Signaling Pathway 365 3.28e-41 -0.409000 2.60e-38
Viral mRNA Translation 84 1.32e-10 0.405000 2.12e-08
APC/C:Cdc20 mediated degradation of Cyclin B 24 6.62e-04 0.401000 1.88e-02
Eukaryotic Translation Termination 87 1.35e-10 0.398000 2.12e-08
Eukaryotic Translation Elongation 88 1.47e-10 0.395000 2.12e-08
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 2.68e-02 -0.385000 2.25e-01
Selenocysteine synthesis 87 1.02e-09 0.378000 1.29e-07
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 89 1.18e-09 0.373000 1.29e-07
NRIF signals cell death from the nucleus 16 1.00e-02 0.372000 1.26e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 10 4.44e-02 0.367000 2.96e-01
Intrinsic Pathway of Fibrin Clot Formation 21 3.81e-03 -0.365000 6.36e-02
Tandem pore domain potassium channels 12 2.88e-02 0.365000 2.36e-01
Regulation of IFNA/IFNB signaling 22 3.31e-03 -0.362000 5.84e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency 95 1.17e-09 0.361000 1.29e-07
Formation of a pool of free 40S subunits 94 1.71e-09 0.359000 1.69e-07
Signaling by cytosolic FGFR1 fusion mutants 17 1.08e-02 -0.357000 1.31e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 41 7.68e-05 -0.357000 2.44e-03
Pausing and recovery of Tat-mediated HIV elongation 27 1.37e-03 0.356000 3.11e-02
Tat-mediated HIV elongation arrest and recovery 27 1.37e-03 0.356000 3.11e-02
Caspase activation via Death Receptors in the presence of ligand 16 1.42e-02 -0.354000 1.55e-01
p75NTR recruits signalling complexes 12 3.56e-02 0.350000 2.58e-01
HIV elongation arrest and recovery 29 1.16e-03 0.348000 2.81e-02
Pausing and recovery of HIV elongation 29 1.16e-03 0.348000 2.81e-02
Formation of the ternary complex, and subsequently, the 43S complex 46 4.47e-05 0.348000 1.58e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 4.67e-02 0.346000 2.97e-01
Interleukin-15 signaling 13 3.08e-02 -0.346000 2.44e-01
SARS-CoV-2 modulates host translation machinery 46 6.31e-05 0.341000 2.04e-03
Selenoamino acid metabolism 103 3.25e-09 0.337000 2.72e-07
Attenuation phase 25 3.51e-03 0.337000 5.93e-02
Chylomicron assembly 10 6.52e-02 0.337000 3.38e-01
L13a-mediated translational silencing of Ceruloplasmin expression 103 4.02e-09 0.335000 3.03e-07
GTP hydrolysis and joining of the 60S ribosomal subunit 104 3.93e-09 0.334000 3.03e-07
Biosynthesis of DHA-derived SPMs 17 1.73e-02 0.334000 1.72e-01
Ribosomal scanning and start codon recognition 53 2.82e-05 0.332000 1.09e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 54 2.39e-05 0.332000 9.72e-04
Translation initiation complex formation 53 3.12e-05 0.331000 1.17e-03
Platelet Adhesion to exposed collagen 15 2.66e-02 -0.331000 2.25e-01
IRAK1 recruits IKK complex 12 4.76e-02 0.330000 2.97e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 12 4.76e-02 0.330000 2.97e-01
p75NTR signals via NF-kB 15 2.70e-02 0.330000 2.26e-01
Assembly Of The HIV Virion 16 2.25e-02 0.330000 2.00e-01
Downregulation of ERBB2:ERBB3 signaling 13 4.02e-02 0.329000 2.80e-01
Regulation of signaling by NODAL 10 7.45e-02 0.326000 3.56e-01
Metabolism of folate and pterines 16 2.41e-02 -0.326000 2.09e-01
Cap-dependent Translation Initiation 111 3.04e-09 0.326000 2.67e-07
Eukaryotic Translation Initiation 111 3.04e-09 0.326000 2.67e-07
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 108 5.73e-09 0.324000 3.63e-07
Nonsense-Mediated Decay (NMD) 108 5.73e-09 0.324000 3.63e-07
Membrane binding and targetting of GAG proteins 14 3.60e-02 0.324000 2.58e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 3.60e-02 0.324000 2.58e-01
STAT5 activation downstream of FLT3 ITD mutants 10 7.65e-02 -0.323000 3.60e-01
APC-Cdc20 mediated degradation of Nek2A 26 4.39e-03 0.323000 6.96e-02
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 2.81e-02 0.317000 2.33e-01
HSF1 activation 27 4.38e-03 0.317000 6.96e-02
Major pathway of rRNA processing in the nucleolus and cytosol 171 1.05e-12 0.315000 4.17e-10
Recycling of bile acids and salts 18 2.08e-02 -0.315000 1.90e-01
CYP2E1 reactions 11 7.18e-02 -0.313000 3.50e-01
Alpha-protein kinase 1 signaling pathway 10 8.69e-02 0.313000 3.88e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 4.35e-02 0.312000 2.91e-01
Prednisone ADME 10 8.79e-02 -0.312000 3.90e-01
HSF1-dependent transactivation 35 1.50e-03 0.310000 3.30e-02
Zinc influx into cells by the SLC39 gene family 10 8.96e-02 0.310000 3.91e-01
NPAS4 regulates expression of target genes 21 1.51e-02 0.306000 1.59e-01
Signal regulatory protein family interactions 16 3.56e-02 -0.303000 2.58e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 3.12e-02 0.302000 2.44e-01
Role of LAT2/NTAL/LAB on calcium mobilization 16 3.72e-02 -0.301000 2.66e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 1.47e-02 0.301000 1.55e-01
SRP-dependent cotranslational protein targeting to membrane 105 1.14e-07 0.299000 6.72e-06
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 7.31e-02 0.299000 3.53e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 4.51e-02 0.299000 2.97e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 4.51e-02 0.299000 2.97e-01
rRNA processing in the nucleus and cytosol 180 4.64e-12 0.299000 1.47e-09
Golgi Cisternae Pericentriolar Stack Reorganization 14 5.48e-02 0.296000 3.19e-01
Cellular response to starvation 147 1.22e-09 0.290000 1.29e-07
Chemokine receptors bind chemokines 56 1.81e-04 -0.289000 5.61e-03
rRNA processing 186 1.48e-11 0.287000 3.35e-09
Regulation of localization of FOXO transcription factors 11 1.02e-01 0.285000 4.15e-01
Cell-extracellular matrix interactions 16 4.88e-02 0.285000 3.03e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 10 1.22e-01 0.283000 4.56e-01
Cytosolic iron-sulfur cluster assembly 10 1.22e-01 0.283000 4.56e-01
mRNA Editing 10 1.23e-01 -0.282000 4.57e-01
Synthesis of PIPs at the late endosome membrane 10 1.24e-01 -0.281000 4.59e-01
Interleukin-2 family signaling 40 2.17e-03 -0.280000 4.35e-02
Regulation of innate immune responses to cytosolic DNA 14 6.99e-02 0.280000 3.43e-01
Mitochondrial iron-sulfur cluster biogenesis 12 9.53e-02 0.278000 4.03e-01
HDL remodeling 10 1.29e-01 0.277000 4.70e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 3.38e-02 0.274000 2.52e-01
Diseases associated with glycosylation precursor biosynthesis 15 6.63e-02 0.274000 3.38e-01
Assembly of active LPL and LIPC lipase complexes 17 5.16e-02 0.273000 3.13e-01
Glutamate and glutamine metabolism 12 1.03e-01 0.272000 4.15e-01
Influenza Viral RNA Transcription and Replication 129 9.45e-08 0.272000 5.77e-06
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 4.83e-03 0.271000 7.44e-02
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.41e-01 0.269000 4.94e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 2.00e-02 0.269000 1.87e-01
Regulation of expression of SLITs and ROBOs 159 4.83e-09 0.269000 3.33e-07
Sensory Perception 571 3.98e-28 -0.268000 2.10e-25
Glucuronidation 25 2.03e-02 -0.268000 1.89e-01
TRAF3-dependent IRF activation pathway 14 8.74e-02 -0.264000 3.89e-01
Pregnenolone biosynthesis 10 1.49e-01 0.263000 5.06e-01
Synthesis of PIPs at the early endosome membrane 15 7.82e-02 -0.263000 3.64e-01
Spry regulation of FGF signaling 16 6.96e-02 0.262000 3.43e-01
Sensory perception of taste 47 1.98e-03 -0.261000 4.03e-02
VLDLR internalisation and degradation 16 7.47e-02 0.257000 3.56e-01
Interleukin-6 signaling 11 1.41e-01 -0.256000 4.94e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 15 8.57e-02 -0.256000 3.86e-01
rRNA modification in the nucleus and cytosol 55 1.06e-03 0.255000 2.70e-02
XBP1(S) activates chaperone genes 47 2.55e-03 0.254000 4.82e-02
FGFR1 ligand binding and activation 17 6.97e-02 0.254000 3.43e-01
Formation of TC-NER Pre-Incision Complex 51 1.70e-03 0.254000 3.64e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 38 6.79e-03 0.254000 9.05e-02
HIV Transcription Elongation 38 6.79e-03 0.254000 9.05e-02
Tat-mediated elongation of the HIV-1 transcript 38 6.79e-03 0.254000 9.05e-02
ERKs are inactivated 13 1.14e-01 0.253000 4.41e-01
Formation of HIV elongation complex in the absence of HIV Tat 40 5.53e-03 0.253000 8.05e-02
Biosynthesis of specialized proresolving mediators (SPMs) 19 5.59e-02 0.253000 3.23e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 1.14e-01 0.253000 4.41e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 5.82e-02 0.251000 3.25e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 5.82e-02 0.251000 3.25e-01
IRE1alpha activates chaperones 49 2.40e-03 0.251000 4.65e-02
Phosphorylation of the APC/C 20 5.26e-02 0.250000 3.14e-01
Regulation of TLR by endogenous ligand 20 5.28e-02 -0.250000 3.14e-01
Protein hydroxylation 18 6.68e-02 0.250000 3.38e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 3.11e-02 0.249000 2.44e-01
SARS-CoV-1-host interactions 90 4.85e-05 0.248000 1.67e-03
Abortive elongation of HIV-1 transcript in the absence of Tat 23 4.01e-02 0.247000 2.80e-01
Diseases of mitotic cell cycle 37 9.69e-03 0.246000 1.23e-01
RNA Polymerase III Transcription Termination 23 4.17e-02 0.245000 2.85e-01
Defensins 36 1.12e-02 -0.244000 1.33e-01
Signaling by EGFR in Cancer 25 3.49e-02 0.244000 2.57e-01
TICAM1-dependent activation of IRF3/IRF7 12 1.44e-01 0.244000 4.99e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 20 5.99e-02 -0.243000 3.28e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 15 1.03e-01 -0.243000 4.17e-01
RNA Polymerase III Chain Elongation 18 7.51e-02 0.242000 3.56e-01
Interleukin-2 signaling 11 1.65e-01 -0.242000 5.34e-01
Regulated proteolysis of p75NTR 11 1.65e-01 0.242000 5.34e-01
RNA Pol II CTD phosphorylation and interaction with CE 26 3.38e-02 0.240000 2.52e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 26 3.38e-02 0.240000 2.52e-01
mRNA Splicing - Minor Pathway 51 3.06e-03 0.240000 5.59e-02
Triglyceride catabolism 23 4.68e-02 -0.239000 2.97e-01
Formation of RNA Pol II elongation complex 52 2.92e-03 0.238000 5.39e-02
RNA Polymerase II Transcription Elongation 52 2.92e-03 0.238000 5.39e-02
MyD88 deficiency (TLR2/4) 16 1.01e-01 -0.237000 4.14e-01
Zinc transporters 15 1.14e-01 0.236000 4.41e-01
DAP12 interactions 40 1.04e-02 -0.234000 1.27e-01
Bile acid and bile salt metabolism 45 6.64e-03 -0.234000 9.05e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 7.26e-02 0.232000 3.52e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 6.71e-02 0.231000 3.38e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 6.71e-02 0.231000 3.38e-01
Glycogen storage diseases 14 1.35e-01 0.230000 4.85e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.67e-02 0.230000 1.69e-01
Methylation 14 1.37e-01 0.230000 4.87e-01
Signaling by NODAL 21 6.87e-02 0.229000 3.43e-01
RNA Polymerase I Transcription Termination 27 4.01e-02 0.228000 2.80e-01
Translesion Synthesis by POLH 19 8.80e-02 0.226000 3.90e-01
Phospholipase C-mediated cascade: FGFR1 16 1.18e-01 0.226000 4.51e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 18 9.86e-02 0.225000 4.11e-01
Senescence-Associated Secretory Phenotype (SASP) 53 4.91e-03 0.223000 7.45e-02
Gap-filling DNA repair synthesis and ligation in TC-NER 62 2.39e-03 0.223000 4.65e-02
Formation of Fibrin Clot (Clotting Cascade) 37 1.91e-02 -0.223000 1.84e-01
Negative regulation of FGFR1 signaling 32 2.95e-02 0.222000 2.41e-01
DNA Damage Recognition in GG-NER 36 2.22e-02 0.220000 1.99e-01
Influenza Infection 148 3.83e-06 0.220000 1.79e-04
FGFRL1 modulation of FGFR1 signaling 13 1.71e-01 0.219000 5.46e-01
Transcriptional Regulation by NPAS4 33 3.03e-02 0.218000 2.43e-01
CASP8 activity is inhibited 11 2.11e-01 -0.218000 5.98e-01
Dimerization of procaspase-8 11 2.11e-01 -0.218000 5.98e-01
Regulation by c-FLIP 11 2.11e-01 -0.218000 5.98e-01
Mitochondrial translation initiation 87 4.54e-04 0.217000 1.33e-02
Signaling by Leptin 11 2.14e-01 -0.217000 5.99e-01
Degradation of cysteine and homocysteine 15 1.46e-01 0.217000 5.00e-01
Hh mutants are degraded by ERAD 54 5.96e-03 0.216000 8.52e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 1.13e-01 0.216000 4.41e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 76 1.17e-03 0.215000 2.81e-02
Inhibition of DNA recombination at telomere 20 9.59e-02 0.215000 4.04e-01
Incretin synthesis, secretion, and inactivation 23 7.49e-02 -0.215000 3.56e-01
Activation of RAC1 11 2.19e-01 -0.214000 6.09e-01
TAK1-dependent IKK and NF-kappa-B activation 41 1.84e-02 0.213000 1.79e-01
Lysine catabolism 12 2.03e-01 -0.212000 5.88e-01
Activation of HOX genes during differentiation 62 3.96e-03 0.211000 6.48e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 62 3.96e-03 0.211000 6.48e-02
Aspirin ADME 44 1.54e-02 -0.211000 1.59e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 2.26e-01 0.211000 6.15e-01
TP53 Regulates Transcription of DNA Repair Genes 57 5.91e-03 0.211000 8.52e-02
Autodegradation of Cdh1 by Cdh1:APC/C 62 4.16e-03 0.210000 6.72e-02
Translation 262 4.37e-09 0.210000 3.15e-07
Mitochondrial translation elongation 87 6.92e-04 0.210000 1.93e-02
NOTCH2 intracellular domain regulates transcription 11 2.30e-01 -0.209000 6.19e-01
Interconversion of nucleotide di- and triphosphates 29 5.13e-02 0.209000 3.13e-01
Ketone body metabolism 10 2.53e-01 -0.209000 6.53e-01
SCF(Skp2)-mediated degradation of p27/p21 58 6.02e-03 0.208000 8.53e-02
Mitochondrial translation termination 87 7.84e-04 0.208000 2.11e-02
ER Quality Control Compartment (ERQC) 20 1.09e-01 0.207000 4.30e-01
Mitochondrial translation 93 5.97e-04 0.206000 1.72e-02
DAP12 signaling 28 6.05e-02 -0.205000 3.30e-01
IRAK4 deficiency (TLR2/4) 17 1.44e-01 -0.204000 4.99e-01
Chaperone Mediated Autophagy 20 1.14e-01 0.204000 4.41e-01
Formation of the Early Elongation Complex 32 4.62e-02 0.204000 2.97e-01
Formation of the HIV-1 Early Elongation Complex 32 4.62e-02 0.204000 2.97e-01
Plasma lipoprotein remodeling 32 4.63e-02 0.203000 2.97e-01
Beta defensins 28 6.29e-02 -0.203000 3.35e-01
Regulation of FZD by ubiquitination 21 1.08e-01 0.203000 4.28e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 6.91e-02 0.202000 3.43e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 1.12e-02 0.201000 1.33e-01
Hormone ligand-binding receptors 13 2.09e-01 -0.201000 5.98e-01
Sema4D induced cell migration and growth-cone collapse 20 1.19e-01 0.201000 4.52e-01
CDK-mediated phosphorylation and removal of Cdc6 71 3.42e-03 0.201000 5.89e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 3.47e-03 0.201000 5.92e-02
Deactivation of the beta-catenin transactivating complex 39 3.03e-02 0.200000 2.43e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 3.30e-03 0.200000 5.84e-02
FGFR1c ligand binding and activation 13 2.11e-01 0.200000 5.98e-01
N-Glycan antennae elongation 15 1.80e-01 -0.200000 5.57e-01
FCERI mediated Ca+2 mobilization 30 5.92e-02 -0.199000 3.27e-01
Negative regulation of FGFR4 signaling 30 5.98e-02 0.198000 3.28e-01
APC/C:Cdc20 mediated degradation of Securin 66 5.34e-03 0.198000 7.94e-02
Tie2 Signaling 18 1.46e-01 -0.198000 5.00e-01
SUMOylation of transcription factors 20 1.25e-01 0.198000 4.60e-01
RHO GTPases activate PKNs 34 4.57e-02 0.198000 2.97e-01
Specification of primordial germ cells 12 2.39e-01 0.196000 6.32e-01
Regulation of CDH11 mRNA translation by microRNAs 10 2.82e-01 -0.196000 6.87e-01
AKT phosphorylates targets in the cytosol 14 2.07e-01 0.195000 5.94e-01
mRNA Capping 28 7.43e-02 0.195000 3.56e-01
Negative regulation of FGFR2 signaling 33 5.30e-02 0.195000 3.14e-01
Interleukin-20 family signaling 24 9.89e-02 -0.195000 4.11e-01
Other interleukin signaling 24 9.92e-02 0.194000 4.11e-01
Formation of the posterior neural plate 10 2.87e-01 0.194000 6.89e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 23 1.07e-01 0.194000 4.28e-01
Hh mutants abrogate ligand secretion 57 1.15e-02 0.193000 1.35e-01
Signaling by FLT3 fusion proteins 19 1.45e-01 -0.193000 5.00e-01
Constitutive Signaling by Overexpressed ERBB2 10 2.91e-01 0.193000 6.91e-01
Pyroptosis 26 8.86e-02 -0.193000 3.90e-01
LGI-ADAM interactions 14 2.11e-01 0.193000 5.98e-01
Synthesis of PE 12 2.48e-01 0.192000 6.46e-01
Signaling by FGFR1 51 1.76e-02 0.192000 1.73e-01
Interleukin-10 signaling 45 2.58e-02 -0.192000 2.19e-01
Eicosanoid ligand-binding receptors 14 2.14e-01 -0.192000 5.99e-01
Dual incision in TC-NER 63 8.40e-03 0.192000 1.09e-01
RHOU GTPase cycle 37 4.47e-02 -0.191000 2.96e-01
Signaling by ROBO receptors 203 2.83e-06 0.190000 1.36e-04
APC/C:Cdc20 mediated degradation of mitotic proteins 74 4.63e-03 0.190000 7.28e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.74e-01 0.190000 5.50e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.74e-01 0.190000 5.50e-01
cGMP effects 15 2.03e-01 -0.190000 5.88e-01
Signaling by Activin 17 1.76e-01 0.190000 5.50e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 24 1.09e-01 -0.189000 4.29e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 1.02e-01 -0.189000 4.15e-01
p38MAPK events 13 2.40e-01 0.188000 6.33e-01
RNA Polymerase I Promoter Escape 28 8.51e-02 0.188000 3.86e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 14 2.26e-01 -0.187000 6.15e-01
Diseases of hemostasis 14 2.26e-01 -0.187000 6.15e-01
FGFR2 mutant receptor activation 32 6.78e-02 0.187000 3.40e-01
PI3K events in ERBB4 signaling 10 3.09e-01 -0.186000 7.00e-01
Phenylalanine and tyrosine metabolism 10 3.10e-01 0.185000 7.00e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 34 6.17e-02 0.185000 3.32e-01
GPVI-mediated activation cascade 34 6.19e-02 -0.185000 3.32e-01
Activated NOTCH1 Transmits Signal to the Nucleus 31 7.50e-02 0.185000 3.56e-01
Defective CFTR causes cystic fibrosis 59 1.46e-02 0.184000 1.55e-01
Regulation of APC/C activators between G1/S and early anaphase 79 4.93e-03 0.183000 7.45e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 12 2.74e-01 -0.182000 6.75e-01
Synthesis of bile acids and bile salts 34 6.63e-02 -0.182000 3.38e-01
Keratan sulfate degradation 15 2.23e-01 -0.182000 6.12e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 6.57e-03 0.181000 9.05e-02
Retinoid metabolism and transport 42 4.19e-02 0.181000 2.85e-01
RNA Polymerase I Transcription 47 3.14e-02 0.181000 2.44e-01
p130Cas linkage to MAPK signaling for integrins 15 2.25e-01 -0.181000 6.15e-01
SCF-beta-TrCP mediated degradation of Emi1 53 2.28e-02 0.181000 2.02e-01
Type I hemidesmosome assembly 11 3.01e-01 0.180000 6.96e-01
p53-Dependent G1 DNA Damage Response 64 1.29e-02 0.180000 1.45e-01
p53-Dependent G1/S DNA damage checkpoint 64 1.29e-02 0.180000 1.45e-01
Ubiquitin-dependent degradation of Cyclin D 50 2.82e-02 0.179000 2.33e-01
Common Pathway of Fibrin Clot Formation 21 1.56e-01 -0.179000 5.17e-01
Negative regulation of FGFR3 signaling 28 1.02e-01 0.178000 4.15e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 3.32e-01 -0.177000 7.23e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 5.90e-02 0.177000 3.27e-01
Gluconeogenesis 33 7.89e-02 0.177000 3.66e-01
G1/S DNA Damage Checkpoints 66 1.34e-02 0.176000 1.50e-01
RHO GTPases activate CIT 19 1.85e-01 0.176000 5.60e-01
Phospholipase C-mediated cascade; FGFR4 14 2.56e-01 0.175000 6.56e-01
Induction of Cell-Cell Fusion 12 2.93e-01 0.175000 6.92e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.08e-01 0.175000 4.29e-01
Regulation of PTEN mRNA translation 25 1.29e-01 0.175000 4.70e-01
Folding of actin by CCT/TriC 10 3.39e-01 -0.175000 7.26e-01
Nucleotide Excision Repair 107 1.81e-03 0.175000 3.82e-02
Androgen biosynthesis 11 3.17e-01 -0.174000 7.05e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 31 9.34e-02 0.174000 3.97e-01
Pyrimidine salvage 10 3.41e-01 -0.174000 7.26e-01
mRNA Splicing 199 2.39e-05 0.174000 9.72e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 1.10e-02 0.173000 1.32e-01
Acyl chain remodelling of PE 24 1.43e-01 0.173000 4.98e-01
RNA Polymerase I Promoter Clearance 46 4.26e-02 0.173000 2.88e-01
Signaling by KIT in disease 20 1.82e-01 -0.172000 5.57e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 1.82e-01 -0.172000 5.57e-01
Translesion synthesis by POLI 17 2.19e-01 0.172000 6.09e-01
MECP2 regulates neuronal receptors and channels 17 2.20e-01 -0.172000 6.09e-01
Phospholipase C-mediated cascade; FGFR2 17 2.20e-01 0.172000 6.09e-01
Telomere C-strand synthesis initiation 11 3.25e-01 -0.171000 7.17e-01
RNA Polymerase II Pre-transcription Events 72 1.20e-02 0.171000 1.39e-01
RMTs methylate histone arginines 30 1.05e-01 0.171000 4.23e-01
SHC-mediated cascade:FGFR1 21 1.76e-01 0.171000 5.50e-01
Na+/Cl- dependent neurotransmitter transporters 18 2.10e-01 0.171000 5.98e-01
Calnexin/calreticulin cycle 25 1.40e-01 0.171000 4.94e-01
Striated Muscle Contraction 35 8.09e-02 0.170000 3.72e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 34 8.56e-02 0.170000 3.86e-01
Hedgehog ligand biogenesis 63 1.94e-02 0.170000 1.86e-01
activated TAK1 mediates p38 MAPK activation 20 1.88e-01 0.170000 5.66e-01
Mitotic Telophase/Cytokinesis 10 3.52e-01 -0.170000 7.34e-01
N-glycan antennae elongation in the medial/trans-Golgi 26 1.34e-01 -0.170000 4.83e-01
Autodegradation of the E3 ubiquitin ligase COP1 50 3.77e-02 0.170000 2.68e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 126 9.91e-04 -0.170000 2.58e-02
RHOV GTPase cycle 36 7.81e-02 -0.170000 3.64e-01
Formation of axial mesoderm 13 2.90e-01 0.170000 6.91e-01
Dectin-1 mediated noncanonical NF-kB signaling 60 2.33e-02 0.169000 2.05e-01
Fertilization 26 1.36e-01 -0.169000 4.86e-01
Signaling by NOTCH3 48 4.30e-02 0.169000 2.89e-01
Transport of organic anions 10 3.57e-01 -0.168000 7.40e-01
Signaling by FGFR 87 6.79e-03 0.168000 9.05e-02
Signaling by NTRK3 (TRKC) 17 2.31e-01 0.168000 6.20e-01
mTORC1-mediated signalling 23 1.66e-01 0.167000 5.34e-01
Keratinization 213 2.66e-05 -0.167000 1.06e-03
Transcription of the HIV genome 62 2.33e-02 0.167000 2.05e-01
Positive epigenetic regulation of rRNA expression 43 5.95e-02 0.166000 3.27e-01
Sema4D in semaphorin signaling 24 1.60e-01 0.166000 5.24e-01
Recognition of DNA damage by PCNA-containing replication complex 29 1.22e-01 0.166000 4.57e-01
Organic cation transport 10 3.65e-01 -0.165000 7.45e-01
Aggrephagy 42 6.36e-02 0.165000 3.35e-01
CD209 (DC-SIGN) signaling 20 2.01e-01 -0.165000 5.87e-01
Fanconi Anemia Pathway 36 8.64e-02 0.165000 3.87e-01
Neurotoxicity of clostridium toxins 10 3.66e-01 0.165000 7.45e-01
Other semaphorin interactions 18 2.26e-01 -0.165000 6.15e-01
B-WICH complex positively regulates rRNA expression 29 1.24e-01 0.165000 4.59e-01
ABC transporter disorders 75 1.37e-02 0.165000 1.51e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 15 2.72e-01 0.164000 6.73e-01
Prolactin receptor signaling 15 2.72e-01 -0.164000 6.73e-01
TBC/RABGAPs 42 6.63e-02 0.164000 3.38e-01
Signaling by BMP 30 1.22e-01 -0.163000 4.56e-01
Signaling by FLT3 ITD and TKD mutants 16 2.59e-01 -0.163000 6.56e-01
Vpu mediated degradation of CD4 50 4.62e-02 0.163000 2.97e-01
Cyclin D associated events in G1 46 5.62e-02 0.163000 3.23e-01
G1 Phase 46 5.62e-02 0.163000 3.23e-01
Regulation of signaling by CBL 22 1.86e-01 0.163000 5.62e-01
NIK–>noncanonical NF-kB signaling 57 3.37e-02 0.163000 2.52e-01
Nucleotide biosynthesis 14 2.93e-01 0.162000 6.92e-01
Signaling by FGFR4 40 7.64e-02 0.162000 3.60e-01
Activation of the AP-1 family of transcription factors 10 3.75e-01 0.162000 7.48e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 13 3.13e-01 -0.162000 7.04e-01
Activation of BAD and translocation to mitochondria 15 2.80e-01 0.161000 6.85e-01
Budding and maturation of HIV virion 28 1.40e-01 0.161000 4.94e-01
FGFR4 ligand binding and activation 13 3.15e-01 0.161000 7.04e-01
SARS-CoV-1 Infection 134 1.35e-03 0.160000 3.11e-02
Synaptic adhesion-like molecules 19 2.27e-01 0.160000 6.16e-01
Termination of translesion DNA synthesis 31 1.23e-01 0.160000 4.58e-01
Activated point mutants of FGFR2 16 2.69e-01 0.160000 6.70e-01
Amino acids regulate mTORC1 52 4.75e-02 0.159000 2.97e-01
Condensation of Prometaphase Chromosomes 11 3.62e-01 0.159000 7.42e-01
IRF3-mediated induction of type I IFN 11 3.63e-01 -0.158000 7.42e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 5.80e-02 0.158000 3.25e-01
Regulation of RUNX3 expression and activity 53 4.66e-02 0.158000 2.97e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 5.34e-02 0.158000 3.14e-01
p53-Independent DNA Damage Response 50 5.34e-02 0.158000 3.14e-01
p53-Independent G1/S DNA damage checkpoint 50 5.34e-02 0.158000 3.14e-01
Signaling by FGFR2 IIIa TM 19 2.34e-01 0.158000 6.24e-01
Metabolism of fat-soluble vitamins 46 6.56e-02 0.157000 3.38e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 1.97e-02 0.157000 1.87e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 2.64e-01 0.157000 6.65e-01
mRNA Splicing - Major Pathway 189 2.15e-04 0.156000 6.57e-03
Advanced glycosylation endproduct receptor signaling 13 3.31e-01 0.156000 7.21e-01
Antimicrobial peptides 78 1.75e-02 -0.156000 1.73e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 10 3.96e-01 0.155000 7.65e-01
Negative regulation of NOTCH4 signaling 52 5.35e-02 0.155000 3.14e-01
TP53 Regulates Transcription of Cell Cycle Genes 49 6.14e-02 0.154000 3.32e-01
G beta:gamma signalling through BTK 17 2.72e-01 -0.154000 6.73e-01
Initial triggering of complement 21 2.22e-01 0.154000 6.11e-01
Transcriptional regulation of testis differentiation 12 3.59e-01 -0.153000 7.40e-01
PINK1-PRKN Mediated Mitophagy 21 2.25e-01 0.153000 6.15e-01
Synthesis of substrates in N-glycan biosythesis 60 4.16e-02 0.152000 2.85e-01
Metabolism of RNA 678 1.36e-11 0.152000 3.35e-09
MicroRNA (miRNA) biogenesis 26 1.81e-01 0.152000 5.57e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 3.09e-01 0.152000 7.00e-01
Metabolism of amino acids and derivatives 345 1.31e-06 0.151000 6.72e-05
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 1.74e-01 0.151000 5.50e-01
APC/C-mediated degradation of cell cycle proteins 86 1.54e-02 0.151000 1.59e-01
Regulation of mitotic cell cycle 86 1.54e-02 0.151000 1.59e-01
FGFR2 alternative splicing 26 1.82e-01 0.151000 5.57e-01
Signaling by NOTCH2 32 1.41e-01 0.150000 4.94e-01
Xenobiotics 24 2.02e-01 -0.150000 5.87e-01
Signaling by NOTCH4 79 2.11e-02 0.150000 1.91e-01
Receptor Mediated Mitophagy 10 4.12e-01 0.150000 7.77e-01
MTOR signalling 40 1.01e-01 0.150000 4.14e-01
Initiation of Nuclear Envelope (NE) Reformation 18 2.73e-01 0.149000 6.74e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 87 1.62e-02 0.149000 1.65e-01
MAP2K and MAPK activation 38 1.12e-01 -0.149000 4.38e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 2.88e-01 0.149000 6.89e-01
Insulin receptor recycling 29 1.66e-01 0.149000 5.34e-01
Glutathione synthesis and recycling 12 3.73e-01 0.148000 7.48e-01
Cyclin E associated events during G1/S transition 81 2.14e-02 0.148000 1.93e-01
ABC transporters in lipid homeostasis 17 2.92e-01 0.148000 6.91e-01
Organic anion transporters 10 4.20e-01 0.147000 7.82e-01
Cyclin A:Cdk2-associated events at S phase entry 83 2.04e-02 0.147000 1.89e-01
Metabolism of Angiotensinogen to Angiotensins 15 3.25e-01 -0.147000 7.17e-01
Signaling by FGFR2 in disease 42 1.00e-01 0.147000 4.13e-01
Transport of vitamins, nucleosides, and related molecules 38 1.18e-01 0.146000 4.51e-01
Heme degradation 16 3.11e-01 -0.146000 7.00e-01
Interleukin-37 signaling 20 2.57e-01 -0.146000 6.56e-01
Transcriptional Regulation by MECP2 60 4.99e-02 -0.146000 3.07e-01
Processing of Capped Intron-Containing Pre-mRNA 263 4.45e-05 0.146000 1.58e-03
DNA Damage Bypass 46 8.86e-02 0.145000 3.90e-01
Dectin-2 family 28 1.84e-01 -0.145000 5.59e-01
Reactions specific to the complex N-glycan synthesis pathway 10 4.28e-01 -0.145000 7.84e-01
Stabilization of p53 55 6.34e-02 0.145000 3.35e-01
Telomere Maintenance 62 4.89e-02 0.145000 3.03e-01
Regulation of TP53 Activity through Methylation 18 2.88e-01 0.145000 6.89e-01
Metabolism of polyamines 55 6.48e-02 0.144000 3.38e-01
Negative epigenetic regulation of rRNA expression 45 9.49e-02 0.144000 4.02e-01
Signaling by FGFR2 72 3.48e-02 0.144000 2.57e-01
Plasma lipoprotein assembly, remodeling, and clearance 73 3.36e-02 0.144000 2.52e-01
Signaling by FGFR3 39 1.21e-01 0.144000 4.55e-01
TICAM1, RIP1-mediated IKK complex recruitment 18 2.92e-01 0.143000 6.91e-01
Global Genome Nucleotide Excision Repair (GG-NER) 81 2.57e-02 0.143000 2.19e-01
Attachment and Entry 9694614 16 3.24e-01 0.142000 7.17e-01
RHO GTPases Activate ROCKs 19 2.83e-01 0.142000 6.88e-01
HS-GAG degradation 21 2.60e-01 0.142000 6.56e-01
NoRC negatively regulates rRNA expression 43 1.08e-01 0.142000 4.28e-01
Selective autophagy 78 3.13e-02 0.141000 2.44e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 3.62e-01 0.141000 7.42e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 38 1.34e-01 -0.140000 4.83e-01
Interleukin-7 signaling 21 2.67e-01 -0.140000 6.68e-01
SHC1 events in ERBB2 signaling 22 2.56e-01 -0.140000 6.56e-01
Activation of NF-kappaB in B cells 64 5.31e-02 0.140000 3.14e-01
Regulation of ornithine decarboxylase (ODC) 49 9.15e-02 0.139000 3.94e-01
Signaling by activated point mutants of FGFR1 11 4.24e-01 0.139000 7.83e-01
PI3K events in ERBB2 signaling 16 3.35e-01 -0.139000 7.26e-01
Acetylcholine regulates insulin secretion 10 4.48e-01 -0.139000 7.86e-01
Laminin interactions 28 2.05e-01 0.138000 5.92e-01
Heme signaling 45 1.09e-01 -0.138000 4.29e-01
Receptor-type tyrosine-protein phosphatases 16 3.39e-01 0.138000 7.26e-01
Interleukin-35 Signalling 12 4.08e-01 -0.138000 7.74e-01
Plasma lipoprotein clearance 37 1.48e-01 0.137000 5.02e-01
InlB-mediated entry of Listeria monocytogenes into host cell 14 3.74e-01 0.137000 7.48e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 49 9.71e-02 0.137000 4.07e-01
RNA Polymerase I Transcription Initiation 42 1.25e-01 0.137000 4.60e-01
Homology Directed Repair 99 1.88e-02 0.137000 1.82e-01
Erythrocytes take up carbon dioxide and release oxygen 12 4.13e-01 0.136000 7.77e-01
O2/CO2 exchange in erythrocytes 12 4.13e-01 0.136000 7.77e-01
Scavenging by Class A Receptors 19 3.04e-01 -0.136000 6.98e-01
FGFR1 mutant receptor activation 30 1.97e-01 -0.136000 5.80e-01
Regulation of TP53 Degradation 36 1.58e-01 0.136000 5.20e-01
Citric acid cycle (TCA cycle) 21 2.81e-01 0.136000 6.85e-01
Maturation of spike protein 9694548 35 1.65e-01 -0.136000 5.34e-01
Glycogen synthesis 13 3.98e-01 0.135000 7.65e-01
Plasma lipoprotein assembly 19 3.07e-01 0.135000 7.00e-01
RNA Polymerase II Transcription Termination 62 6.69e-02 0.135000 3.38e-01
Reversible hydration of carbon dioxide 11 4.40e-01 -0.134000 7.84e-01
Assembly of the pre-replicative complex 82 3.56e-02 0.134000 2.58e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 55 8.54e-02 0.134000 3.86e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 20 3.00e-01 0.134000 6.96e-01
RORA activates gene expression 17 3.40e-01 -0.134000 7.26e-01
Cleavage of the damaged purine 11 4.43e-01 -0.134000 7.84e-01
Depurination 11 4.43e-01 -0.134000 7.84e-01
Recognition and association of DNA glycosylase with site containing an affected purine 11 4.43e-01 -0.134000 7.84e-01
Phosphorylation of CD3 and TCR zeta chains 20 3.01e-01 -0.134000 6.96e-01
RAS processing 23 2.68e-01 0.133000 6.69e-01
Sulfur amino acid metabolism 28 2.22e-01 0.133000 6.11e-01
Regulation of RAS by GAPs 65 6.32e-02 0.133000 3.35e-01
G alpha (i) signalling events 305 6.24e-05 -0.133000 2.04e-03
Regulation of gene expression by Hypoxia-inducible Factor 11 4.45e-01 0.133000 7.85e-01
Ribavirin ADME 11 4.46e-01 0.133000 7.86e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 54 9.22e-02 0.132000 3.94e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 54 9.22e-02 0.132000 3.94e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 54 9.22e-02 0.132000 3.94e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 54 9.22e-02 0.132000 3.94e-01
Signaling by NOTCH1 in Cancer 54 9.22e-02 0.132000 3.94e-01
Signaling by ERBB2 ECD mutants 15 3.75e-01 0.132000 7.48e-01
Suppression of phagosomal maturation 13 4.09e-01 0.132000 7.76e-01
G beta:gamma signalling through PLC beta 20 3.07e-01 -0.132000 7.00e-01
MET activates RAP1 and RAC1 11 4.49e-01 -0.132000 7.86e-01
Unfolded Protein Response (UPR) 91 2.97e-02 0.132000 2.41e-01
Degradation of DVL 55 9.07e-02 0.132000 3.94e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 76 4.70e-02 0.132000 2.97e-01
Translesion synthesis by REV1 16 3.62e-01 0.132000 7.42e-01
SHC-mediated cascade:FGFR2 22 2.86e-01 0.131000 6.89e-01
Diseases of carbohydrate metabolism 30 2.13e-01 0.131000 5.99e-01
Defective B4GALT7 causes EDS, progeroid type 17 3.49e-01 0.131000 7.33e-01
Regulation of pyruvate dehydrogenase (PDH) complex 14 3.96e-01 0.131000 7.65e-01
Switching of origins to a post-replicative state 90 3.15e-02 0.131000 2.44e-01
Purine salvage 12 4.32e-01 0.131000 7.84e-01
RNA Polymerase III Abortive And Retractive Initiation 41 1.47e-01 0.131000 5.00e-01
RNA Polymerase III Transcription 41 1.47e-01 0.131000 5.00e-01
Cytosolic sensors of pathogen-associated DNA 60 7.96e-02 0.131000 3.67e-01
Scavenging of heme from plasma 12 4.33e-01 -0.131000 7.84e-01
Downregulation of ERBB2 signaling 28 2.32e-01 0.130000 6.20e-01
mRNA 3’-end processing 53 1.00e-01 0.130000 4.13e-01
DNA Replication 125 1.17e-02 0.130000 1.37e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 16 3.68e-01 0.130000 7.47e-01
Synthesis of DNA 118 1.46e-02 0.130000 1.55e-01
Glyoxylate metabolism and glycine degradation 30 2.18e-01 0.130000 6.09e-01
Processing of DNA double-strand break ends 61 7.92e-02 0.130000 3.66e-01
A tetrasaccharide linker sequence is required for GAG synthesis 23 2.81e-01 0.130000 6.85e-01
Elastic fibre formation 44 1.37e-01 0.130000 4.87e-01
G beta:gamma signalling through CDC42 19 3.29e-01 -0.129000 7.20e-01
Intra-Golgi traffic 43 1.43e-01 -0.129000 4.98e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 1.04e-01 0.129000 4.20e-01
HDR through Homologous Recombination (HRR) 64 7.44e-02 0.129000 3.56e-01
Regulation of NPAS4 gene expression 13 4.21e-01 0.129000 7.82e-01
Maturation of nucleoprotein 9683610 11 4.61e-01 0.128000 7.91e-01
Association of TriC/CCT with target proteins during biosynthesis 36 1.83e-01 -0.128000 5.57e-01
Vif-mediated degradation of APOBEC3G 50 1.18e-01 0.128000 4.51e-01
SHC-mediated cascade:FGFR4 19 3.35e-01 0.128000 7.26e-01
Triglyceride metabolism 35 1.93e-01 -0.127000 5.69e-01
SHC1 events in ERBB4 signaling 14 4.10e-01 -0.127000 7.76e-01
Early Phase of HIV Life Cycle 14 4.10e-01 0.127000 7.76e-01
ADP signalling through P2Y purinoceptor 12 22 3.06e-01 -0.126000 7.00e-01
Resolution of Abasic Sites (AP sites) 37 1.86e-01 0.126000 5.60e-01
Detoxification of Reactive Oxygen Species 35 1.98e-01 0.126000 5.81e-01
DCC mediated attractive signaling 14 4.15e-01 -0.126000 7.80e-01
Interleukin receptor SHC signaling 24 2.87e-01 -0.125000 6.89e-01
Mitophagy 27 2.59e-01 0.125000 6.56e-01
Signal attenuation 10 4.94e-01 0.125000 8.17e-01
Phase 2 - plateau phase 14 4.18e-01 0.125000 7.82e-01
Phospholipase C-mediated cascade; FGFR3 12 4.54e-01 0.125000 7.90e-01
Miscellaneous transport and binding events 23 3.00e-01 -0.125000 6.96e-01
Uptake and actions of bacterial toxins 29 2.45e-01 0.125000 6.39e-01
Dual Incision in GG-NER 39 1.78e-01 0.125000 5.55e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 93 3.84e-02 0.124000 2.72e-01
DNA Double Strand Break Response 42 1.66e-01 0.124000 5.34e-01
Frs2-mediated activation 12 4.60e-01 0.123000 7.91e-01
Signalling to ERKs 34 2.14e-01 0.123000 5.99e-01
Regulation of TNFR1 signaling 45 1.53e-01 0.123000 5.12e-01
VEGFR2 mediated cell proliferation 19 3.54e-01 0.123000 7.36e-01
Defective B3GAT3 causes JDSSDHD 17 3.82e-01 0.123000 7.52e-01
FCERI mediated MAPK activation 32 2.30e-01 -0.123000 6.19e-01
Sodium/Calcium exchangers 11 4.82e-01 -0.122000 8.07e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 3.98e-01 0.122000 7.65e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 50 1.35e-01 0.122000 4.85e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 113 2.52e-02 -0.122000 2.17e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 4.86e-01 -0.121000 8.10e-01
Glycosphingolipid biosynthesis 10 5.08e-01 0.121000 8.18e-01
TNFR1-induced NF-kappa-B signaling pathway 29 2.60e-01 0.121000 6.56e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 2.96e-01 0.121000 6.93e-01
RNA polymerase II transcribes snRNA genes 77 6.72e-02 0.121000 3.38e-01
GP1b-IX-V activation signalling 11 4.89e-01 -0.121000 8.12e-01
ERK/MAPK targets 20 3.52e-01 0.120000 7.34e-01
Transport of Ribonucleoproteins into the Host Nucleus 30 2.55e-01 -0.120000 6.56e-01
Cross-presentation of soluble exogenous antigens (endosomes) 46 1.60e-01 0.120000 5.24e-01
Translation of Structural Proteins 9683701 29 2.65e-01 0.120000 6.68e-01
Regulation of Apoptosis 51 1.41e-01 0.119000 4.94e-01
FGFR2c ligand binding and activation 12 4.75e-01 0.119000 8.02e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 5.14e-01 0.119000 8.20e-01
Downstream signaling events of B Cell Receptor (BCR) 78 6.92e-02 0.119000 3.43e-01
Passive transport by Aquaporins 13 4.59e-01 0.119000 7.91e-01
DNA Double-Strand Break Repair 129 1.99e-02 0.119000 1.87e-01
Regulation of TP53 Activity through Phosphorylation 88 5.49e-02 0.118000 3.19e-01
Class I peroxisomal membrane protein import 19 3.72e-01 0.118000 7.48e-01
BBSome-mediated cargo-targeting to cilium 23 3.26e-01 -0.118000 7.18e-01
RAC1 GTPase cycle 170 7.82e-03 -0.118000 1.03e-01
UCH proteinases 81 6.67e-02 0.118000 3.38e-01
Interactions of Vpr with host cellular proteins 33 2.45e-01 -0.117000 6.39e-01
ERBB2 Regulates Cell Motility 15 4.33e-01 -0.117000 7.84e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 20 3.66e-01 0.117000 7.45e-01
Regulation of TP53 Expression and Degradation 37 2.19e-01 0.117000 6.09e-01
Generation of second messenger molecules 30 2.70e-01 -0.116000 6.72e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 25 3.14e-01 0.116000 7.04e-01
Activation of the TFAP2 (AP-2) family of transcription factors 11 5.04e-01 0.116000 8.18e-01
Metabolism of nucleotides 95 5.02e-02 0.116000 3.07e-01
Downregulation of TGF-beta receptor signaling 26 3.05e-01 0.116000 6.99e-01
Defective pyroptosis 11 5.05e-01 -0.116000 8.18e-01
HIV Life Cycle 139 1.80e-02 0.116000 1.76e-01
Insulin processing 24 3.25e-01 -0.116000 7.17e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 41 1.99e-01 0.116000 5.83e-01
Erythropoietin activates RAS 14 4.53e-01 0.116000 7.90e-01
NS1 Mediated Effects on Host Pathways 39 2.11e-01 -0.116000 5.98e-01
PIWI-interacting RNA (piRNA) biogenesis 29 2.81e-01 0.116000 6.85e-01
Processive synthesis on the lagging strand 14 4.54e-01 0.116000 7.90e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 95 5.20e-02 0.115000 3.14e-01
DNA Replication Pre-Initiation 97 4.96e-02 0.115000 3.06e-01
HIV Transcription Initiation 43 1.92e-01 0.115000 5.68e-01
RNA Polymerase II HIV Promoter Escape 43 1.92e-01 0.115000 5.68e-01
RNA Polymerase II Promoter Escape 43 1.92e-01 0.115000 5.68e-01
RNA Polymerase II Transcription Initiation 43 1.92e-01 0.115000 5.68e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 43 1.92e-01 0.115000 5.68e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 43 1.92e-01 0.115000 5.68e-01
Late Phase of HIV Life Cycle 126 2.58e-02 0.115000 2.19e-01
IL-6-type cytokine receptor ligand interactions 17 4.12e-01 0.115000 7.77e-01
MyD88 cascade initiated on plasma membrane 91 5.80e-02 0.115000 3.25e-01
Toll Like Receptor 10 (TLR10) Cascade 91 5.80e-02 0.115000 3.25e-01
Toll Like Receptor 5 (TLR5) Cascade 91 5.80e-02 0.115000 3.25e-01
PCNA-Dependent Long Patch Base Excision Repair 21 3.65e-01 0.114000 7.45e-01
Meiotic recombination 26 3.15e-01 -0.114000 7.04e-01
Trafficking and processing of endosomal TLR 11 5.14e-01 0.114000 8.20e-01
RNA Polymerase III Transcription Initiation 36 2.38e-01 0.114000 6.32e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 52 1.57e-01 0.113000 5.20e-01
Iron uptake and transport 57 1.40e-01 0.113000 4.94e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 14 4.64e-01 -0.113000 7.93e-01
Cellular response to heat stress 95 5.72e-02 0.113000 3.25e-01
Retrograde transport at the Trans-Golgi-Network 47 1.81e-01 -0.113000 5.57e-01
Regulation of MECP2 expression and activity 30 2.86e-01 -0.113000 6.89e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29 2.95e-01 -0.112000 6.92e-01
Nitric oxide stimulates guanylate cyclase 22 3.62e-01 -0.112000 7.42e-01
Asymmetric localization of PCP proteins 62 1.26e-01 0.112000 4.60e-01
Translesion synthesis by POLK 17 4.24e-01 0.112000 7.83e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 3.06e-01 0.112000 7.00e-01
Mitochondrial RNA degradation 10 5.43e-01 0.111000 8.38e-01
Late endosomal microautophagy 33 2.74e-01 0.110000 6.75e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 4.94e-01 0.110000 8.17e-01
EPH-ephrin mediated repulsion of cells 50 1.81e-01 0.109000 5.57e-01
Degradation of GLI2 by the proteasome 58 1.51e-01 0.109000 5.07e-01
G2/M Checkpoints 129 3.25e-02 0.109000 2.49e-01
Cell Cycle Checkpoints 248 3.10e-03 0.109000 5.59e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 4.38e-01 0.109000 7.84e-01
Cell recruitment (pro-inflammatory response) 26 3.38e-01 -0.109000 7.26e-01
Purinergic signaling in leishmaniasis infection 26 3.38e-01 -0.109000 7.26e-01
Formation of Incision Complex in GG-NER 40 2.36e-01 0.108000 6.28e-01
Prolonged ERK activation events 14 4.83e-01 0.108000 8.07e-01
Chromosome Maintenance 86 8.31e-02 0.108000 3.80e-01
Signaling by FGFR1 in disease 37 2.57e-01 -0.108000 6.56e-01
Somitogenesis 53 1.76e-01 0.107000 5.50e-01
TNF signaling 53 1.77e-01 0.107000 5.51e-01
GRB2 events in ERBB2 signaling 16 4.58e-01 -0.107000 7.91e-01
FGFR2 ligand binding and activation 19 4.21e-01 0.107000 7.82e-01
MAPK6/MAPK4 signaling 89 8.25e-02 0.106000 3.78e-01
Epigenetic regulation of gene expression 118 4.57e-02 0.106000 2.97e-01
Metabolic disorders of biological oxidation enzymes 32 2.98e-01 0.106000 6.96e-01
Cellular responses to stress 714 1.22e-06 0.106000 6.46e-05
Muscle contraction 197 1.03e-02 0.106000 1.27e-01
G0 and Early G1 27 3.41e-01 0.106000 7.26e-01
Leading Strand Synthesis 13 5.10e-01 0.106000 8.19e-01
Polymerase switching 13 5.10e-01 0.106000 8.19e-01
Glycogen metabolism 22 3.94e-01 0.105000 7.65e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 54 1.82e-01 0.105000 5.57e-01
Cell surface interactions at the vascular wall 129 3.95e-02 -0.105000 2.79e-01
G-protein activation 24 3.76e-01 -0.104000 7.48e-01
Signalling to RAS 20 4.20e-01 0.104000 7.82e-01
Estrogen-dependent gene expression 91 8.62e-02 0.104000 3.87e-01
FOXO-mediated transcription 65 1.47e-01 0.104000 5.00e-01
Phase 0 - rapid depolarisation 31 3.18e-01 0.104000 7.06e-01
Adenylate cyclase inhibitory pathway 14 5.02e-01 0.104000 8.18e-01
MET receptor recycling 10 5.71e-01 0.104000 8.52e-01
Cellular responses to stimuli 728 1.83e-06 0.104000 9.06e-05
Interleukin-1 signaling 109 6.19e-02 0.103000 3.32e-01
NCAM1 interactions 41 2.53e-01 0.103000 6.53e-01
Binding and Uptake of Ligands by Scavenger Receptors 41 2.53e-01 -0.103000 6.53e-01
G beta:gamma signalling through PI3Kgamma 25 3.73e-01 -0.103000 7.48e-01
EGFR downregulation 30 3.29e-01 0.103000 7.20e-01
FGFR3 mutant receptor activation 11 5.55e-01 0.103000 8.43e-01
Signaling by activated point mutants of FGFR3 11 5.55e-01 0.103000 8.43e-01
CD28 dependent Vav1 pathway 11 5.55e-01 -0.103000 8.43e-01
PTEN Regulation 150 2.98e-02 0.103000 2.41e-01
Oncogene Induced Senescence 35 2.94e-01 0.102000 6.92e-01
Depolymerization of the Nuclear Lamina 14 5.07e-01 0.102000 8.18e-01
Cellular response to hypoxia 71 1.35e-01 0.102000 4.85e-01
FGFR3 ligand binding and activation 12 5.43e-01 0.101000 8.38e-01
FGFR3c ligand binding and activation 12 5.43e-01 0.101000 8.38e-01
Degradation of AXIN 53 2.02e-01 0.101000 5.87e-01
Acyl chain remodelling of PI 16 4.83e-01 0.101000 8.07e-01
Signaling by PDGFR in disease 20 4.34e-01 -0.101000 7.84e-01
Acyl chain remodelling of PC 26 3.74e-01 0.101000 7.48e-01
Transferrin endocytosis and recycling 30 3.41e-01 0.100000 7.26e-01
CLEC7A (Dectin-1) signaling 96 8.94e-02 0.100000 3.91e-01
ADP signalling through P2Y purinoceptor 1 25 3.86e-01 -0.100000 7.55e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 15 5.02e-01 0.100000 8.18e-01
Amino acid transport across the plasma membrane 30 3.43e-01 0.100000 7.27e-01
VxPx cargo-targeting to cilium 20 4.39e-01 0.099900 7.84e-01
Sphingolipid de novo biosynthesis 32 3.29e-01 -0.099600 7.20e-01
PKR-mediated signaling 72 1.44e-01 0.099600 4.99e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 30 3.46e-01 -0.099500 7.29e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 30 3.46e-01 -0.099500 7.29e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 68 1.56e-01 0.099500 5.17e-01
Presynaptic depolarization and calcium channel opening 12 5.51e-01 0.099400 8.43e-01
S Phase 157 3.16e-02 0.099300 2.44e-01
Cytosolic sulfonation of small molecules 21 4.32e-01 0.099100 7.84e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 5.52e-01 -0.099000 8.43e-01
TP53 Regulates Metabolic Genes 83 1.19e-01 0.098900 4.52e-01
TGF-beta receptor signaling activates SMADs 47 2.42e-01 0.098700 6.35e-01
FOXO-mediated transcription of cell death genes 15 5.09e-01 0.098500 8.19e-01
Molecules associated with elastic fibres 37 3.00e-01 0.098400 6.96e-01
FOXO-mediated transcription of cell cycle genes 16 4.96e-01 0.098400 8.17e-01
Respiratory electron transport 90 1.07e-01 0.098200 4.28e-01
Myogenesis 29 3.60e-01 -0.098200 7.42e-01
Gastrulation 113 7.20e-02 0.097900 3.50e-01
Smooth Muscle Contraction 43 2.66e-01 0.097900 6.68e-01
Neddylation 232 1.03e-02 0.097700 1.27e-01
G1/S Transition 126 5.82e-02 0.097700 3.25e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 62 1.83e-01 0.097700 5.57e-01
Inflammasomes 21 4.39e-01 -0.097500 7.84e-01
Vpr-mediated nuclear import of PICs 32 3.40e-01 -0.097400 7.26e-01
HIV Infection 216 1.36e-02 0.097300 1.51e-01
Tryptophan catabolism 12 5.60e-01 -0.097300 8.48e-01
COPII-mediated vesicle transport 66 1.73e-01 0.097000 5.49e-01
Signaling by ALK fusions and activated point mutants 51 2.31e-01 -0.097000 6.19e-01
Signaling by ALK in cancer 51 2.31e-01 -0.097000 6.19e-01
Regulation of CDH11 Expression and Function 28 3.75e-01 0.096900 7.48e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 3.75e-01 0.096800 7.48e-01
RUNX2 regulates osteoblast differentiation 22 4.33e-01 0.096600 7.84e-01
Formation of the anterior neural plate 11 5.79e-01 0.096500 8.56e-01
Activation of kainate receptors upon glutamate binding 29 3.69e-01 -0.096400 7.48e-01
Transcriptional regulation by RUNX3 93 1.08e-01 0.096400 4.28e-01
Vitamin B5 (pantothenate) metabolism 19 4.68e-01 -0.096100 7.98e-01
Degradation of GLI1 by the proteasome 58 2.06e-01 0.096100 5.92e-01
DNA Repair 276 6.08e-03 0.095900 8.53e-02
ERBB2 Activates PTK6 Signaling 13 5.50e-01 -0.095800 8.43e-01
SUMOylation of intracellular receptors 29 3.72e-01 -0.095700 7.48e-01
RHOJ GTPase cycle 51 2.37e-01 -0.095700 6.30e-01
Surfactant metabolism 28 3.81e-01 0.095600 7.52e-01
Presynaptic function of Kainate receptors 21 4.49e-01 -0.095500 7.86e-01
Downstream signaling of activated FGFR1 31 3.58e-01 0.095300 7.40e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 28 3.83e-01 -0.095200 7.54e-01
Deadenylation of mRNA 25 4.10e-01 -0.095100 7.76e-01
LDL clearance 19 4.75e-01 0.094700 8.02e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 17 5.01e-01 -0.094200 8.18e-01
Nuclear events mediated by NFE2L2 94 1.15e-01 0.094100 4.42e-01
SUMOylation of DNA damage response and repair proteins 71 1.71e-01 -0.094000 5.46e-01
Regulation of HSF1-mediated heat shock response 78 1.51e-01 0.094000 5.07e-01
Peptide hormone metabolism 81 1.44e-01 -0.093800 4.99e-01
Constitutive Signaling by EGFRvIII 15 5.30e-01 0.093600 8.31e-01
Signaling by EGFRvIII in Cancer 15 5.30e-01 0.093600 8.31e-01
O-glycosylation of TSR domain-containing proteins 37 3.26e-01 0.093400 7.17e-01
Regulation of Complement cascade 45 2.80e-01 -0.093100 6.85e-01
Mitotic G1 phase and G1/S transition 144 5.38e-02 0.093000 3.15e-01
TNFs bind their physiological receptors 25 4.21e-01 -0.093000 7.82e-01
Mitotic Spindle Checkpoint 106 9.80e-02 0.093000 4.10e-01
Mitotic Metaphase and Anaphase 222 1.69e-02 0.092900 1.70e-01
Protein methylation 16 5.20e-01 0.092900 8.21e-01
Drug ADME 106 9.86e-02 -0.092800 4.11e-01
GLI3 is processed to GLI3R by the proteasome 58 2.21e-01 0.092800 6.11e-01
SARS-CoV-2 modulates autophagy 11 5.94e-01 -0.092800 8.64e-01
Germ layer formation at gastrulation 16 5.22e-01 -0.092500 8.23e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 23 4.42e-01 0.092500 7.84e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 23 4.42e-01 0.092500 7.84e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 23 4.42e-01 0.092500 7.84e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 23 4.42e-01 0.092500 7.84e-01
Impaired BRCA2 binding to PALB2 23 4.42e-01 0.092500 7.84e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 42 3.00e-01 -0.092400 6.96e-01
Formation of tubulin folding intermediates by CCT/TriC 26 4.15e-01 -0.092300 7.80e-01
NEP/NS2 Interacts with the Cellular Export Machinery 30 3.82e-01 -0.092300 7.52e-01
Signaling by TGF-beta Receptor Complex 92 1.26e-01 0.092300 4.60e-01
Formation of annular gap junctions 11 5.96e-01 0.092300 8.64e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 74 1.70e-01 -0.092200 5.46e-01
Regulation of RUNX2 expression and activity 71 1.79e-01 0.092100 5.57e-01
Butyrophilin (BTN) family interactions 12 5.81e-01 -0.092000 8.56e-01
RAC2 GTPase cycle 80 1.56e-01 -0.091800 5.17e-01
DAG and IP3 signaling 39 3.22e-01 -0.091600 7.15e-01
Regulation of TP53 Activity through Acetylation 29 3.94e-01 0.091500 7.65e-01
Disorders of transmembrane transporters 167 4.23e-02 0.091000 2.86e-01
Separation of Sister Chromatids 179 3.56e-02 0.091000 2.58e-01
ABC-family proteins mediated transport 98 1.20e-01 0.090900 4.52e-01
RHOG GTPase cycle 69 1.92e-01 -0.090800 5.68e-01
Thromboxane signalling through TP receptor 24 4.41e-01 -0.090800 7.84e-01
CDC42 GTPase cycle 143 6.09e-02 -0.090700 3.31e-01
Ca-dependent events 35 3.54e-01 -0.090600 7.36e-01
Transcriptional regulation by RUNX2 116 9.28e-02 0.090300 3.96e-01
Mitotic Anaphase 221 2.08e-02 0.090200 1.90e-01
Nuclear Events (kinase and transcription factor activation) 60 2.27e-01 0.090100 6.16e-01
Cytochrome c-mediated apoptotic response 12 5.89e-01 -0.090100 8.60e-01
Killing mechanisms 11 6.05e-01 0.090000 8.66e-01
WNT5:FZD7-mediated leishmania damping 11 6.05e-01 0.090000 8.66e-01
Uptake and function of anthrax toxins 11 6.06e-01 -0.089900 8.66e-01
PI-3K cascade:FGFR1 21 4.76e-01 0.089800 8.03e-01
RHO GTPases activate KTN1 11 6.06e-01 0.089800 8.66e-01
Orc1 removal from chromatin 69 1.98e-01 0.089600 5.81e-01
Signaling by SCF-KIT 43 3.11e-01 -0.089300 7.00e-01
Lysosome Vesicle Biogenesis 33 3.76e-01 0.089100 7.48e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 6.11e-01 -0.088600 8.70e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 5.97e-01 -0.088200 8.64e-01
Prostacyclin signalling through prostacyclin receptor 19 5.06e-01 -0.088100 8.18e-01
Branched-chain amino acid catabolism 20 4.95e-01 0.088100 8.17e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 5.68e-01 0.088100 8.52e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 19 5.06e-01 -0.088000 8.18e-01
Triglyceride biosynthesis 12 5.98e-01 0.088000 8.65e-01
Transport of bile salts and organic acids, metal ions and amine compounds 82 1.69e-01 0.087800 5.43e-01
Signaling by Non-Receptor Tyrosine Kinases 55 2.60e-01 0.087800 6.56e-01
Signaling by PTK6 55 2.60e-01 0.087800 6.56e-01
FRS-mediated FGFR1 signaling 23 4.66e-01 0.087700 7.95e-01
Regulation of PTEN gene transcription 59 2.44e-01 0.087600 6.39e-01
Regulation of TP53 Activity through Association with Co-factors 14 5.71e-01 0.087400 8.52e-01
PLC beta mediated events 47 3.01e-01 -0.087300 6.96e-01
G2/M DNA damage checkpoint 58 2.51e-01 0.087100 6.51e-01
SHC1 events in EGFR signaling 14 5.74e-01 0.086800 8.54e-01
Voltage gated Potassium channels 42 3.31e-01 0.086700 7.21e-01
TNFR2 non-canonical NF-kB pathway 94 1.47e-01 0.086500 5.00e-01
Azathioprine ADME 22 4.83e-01 0.086400 8.07e-01
NCAM signaling for neurite out-growth 62 2.40e-01 0.086300 6.33e-01
CLEC7A (Dectin-1) induces NFAT activation 11 6.20e-01 -0.086300 8.76e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 14 5.76e-01 -0.086300 8.56e-01
SHC-mediated cascade:FGFR3 17 5.38e-01 0.086200 8.36e-01
Homologous DNA Pairing and Strand Exchange 41 3.40e-01 0.086200 7.26e-01
GPCR ligand binding 443 1.84e-03 -0.086200 3.85e-02
Maturation of nucleoprotein 9694631 15 5.64e-01 0.086100 8.48e-01
Cardiac conduction 125 9.66e-02 0.086000 4.06e-01
Hedgehog ‘on’ state 83 1.77e-01 0.085800 5.51e-01
The citric acid (TCA) cycle and respiratory electron transport 143 7.67e-02 0.085700 3.60e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 5.41e-01 0.085700 8.37e-01
RHO GTPases activate PAKs 19 5.18e-01 0.085700 8.21e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 15 5.66e-01 0.085600 8.50e-01
WNT ligand biogenesis and trafficking 25 4.59e-01 0.085500 7.91e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 5.94e-01 0.085500 8.64e-01
Synthesis of IP3 and IP4 in the cytosol 25 4.62e-01 0.085000 7.91e-01
RHOQ GTPase cycle 57 2.67e-01 -0.085000 6.68e-01
Netrin-1 signaling 49 3.04e-01 -0.084900 6.98e-01
Signaling by high-kinase activity BRAF mutants 34 3.93e-01 -0.084700 7.65e-01
Acyl chain remodelling of PS 21 5.04e-01 0.084300 8.18e-01
KEAP1-NFE2L2 pathway 126 1.02e-01 0.084300 4.15e-01
Negative regulators of DDX58/IFIH1 signaling 33 4.03e-01 0.084100 7.69e-01
Formation of paraxial mesoderm 65 2.42e-01 0.083900 6.35e-01
RHOBTB1 GTPase cycle 22 4.96e-01 -0.083900 8.17e-01
Axon guidance 526 9.80e-04 0.083800 2.58e-02
Glycerophospholipid biosynthesis 114 1.23e-01 0.083600 4.57e-01
GRB2 events in EGFR signaling 13 6.02e-01 0.083600 8.66e-01
RHOBTB2 GTPase cycle 22 4.98e-01 -0.083500 8.17e-01
FLT3 signaling in disease 28 4.45e-01 -0.083300 7.85e-01
Potassium Channels 102 1.46e-01 0.083200 5.00e-01
RIP-mediated NFkB activation via ZBP1 16 5.66e-01 0.083000 8.50e-01
Transcriptional Regulation by TP53 346 8.00e-03 0.082900 1.05e-01
Sensory processing of sound by inner hair cells of the cochlea 64 2.51e-01 0.082900 6.52e-01
Metabolism of cofactors 19 5.32e-01 0.082800 8.31e-01
Heparan sulfate/heparin (HS-GAG) metabolism 52 3.03e-01 0.082500 6.98e-01
MyD88 dependent cascade initiated on endosome 96 1.62e-01 0.082500 5.30e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 96 1.62e-01 0.082500 5.30e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 71 2.29e-01 0.082500 6.19e-01
Complement cascade 56 2.87e-01 -0.082300 6.89e-01
Ion transport by P-type ATPases 51 3.09e-01 -0.082300 7.00e-01
Metal ion SLC transporters 23 4.95e-01 0.082200 8.17e-01
Signaling by ERBB2 49 3.20e-01 0.082100 7.11e-01
Unwinding of DNA 12 6.23e-01 0.082000 8.76e-01
MAPK3 (ERK1) activation 10 6.53e-01 -0.082000 8.94e-01
Activation of gene expression by SREBF (SREBP) 42 3.59e-01 0.081800 7.40e-01
ROS and RNS production in phagocytes 35 4.03e-01 0.081700 7.69e-01
G-protein beta:gamma signalling 30 4.40e-01 -0.081500 7.84e-01
Glutamate Neurotransmitter Release Cycle 23 4.99e-01 0.081400 8.18e-01
Regulation of gene expression in beta cells 21 5.19e-01 0.081300 8.21e-01
Mitochondrial Fatty Acid Beta-Oxidation 35 4.05e-01 0.081300 7.71e-01
Metabolism of amine-derived hormones 17 5.62e-01 0.081100 8.48e-01
NGF-stimulated transcription 39 3.82e-01 0.080900 7.52e-01
Activation of BH3-only proteins 30 4.43e-01 0.080900 7.84e-01
SUMOylation of ubiquitinylation proteins 37 3.95e-01 -0.080800 7.65e-01
ESR-mediated signaling 161 7.79e-02 0.080500 3.64e-01
ATF6 (ATF6-alpha) activates chaperones 11 6.44e-01 0.080400 8.89e-01
Inactivation of CSF3 (G-CSF) signaling 23 5.05e-01 0.080300 8.18e-01
GPCR downstream signalling 604 7.50e-04 -0.080100 2.05e-02
Nervous system development 550 1.32e-03 0.079900 3.11e-02
Nuclear Pore Complex (NPC) Disassembly 34 4.23e-01 -0.079400 7.83e-01
Signaling by NOTCH 183 6.57e-02 0.078800 3.38e-01
Assembly of the ORC complex at the origin of replication 10 6.67e-01 -0.078500 9.04e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 19 5.54e-01 0.078500 8.43e-01
NOD1/2 Signaling Pathway 33 4.36e-01 0.078400 7.84e-01
Transport of the SLBP independent Mature mRNA 33 4.37e-01 -0.078200 7.84e-01
DNA strand elongation 31 4.52e-01 0.078100 7.89e-01
Keratan sulfate/keratin metabolism 36 4.17e-01 -0.078100 7.81e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 5.89e-01 0.078100 8.60e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 39 4.02e-01 0.077500 7.69e-01
Diseases of DNA Double-Strand Break Repair 39 4.02e-01 0.077500 7.69e-01
Fatty acids 15 6.03e-01 -0.077500 8.66e-01
Diseases of metabolism 234 4.11e-02 0.077400 2.84e-01
Beta-catenin phosphorylation cascade 16 5.94e-01 -0.077000 8.64e-01
SUMOylation of chromatin organization proteins 54 3.28e-01 -0.076900 7.19e-01
Formation of WDR5-containing histone-modifying complexes 37 4.19e-01 0.076800 7.82e-01
eNOS activation 10 6.75e-01 0.076600 9.06e-01
Ethanol oxidation 12 6.46e-01 0.076500 8.90e-01
Defective B3GALTL causes PpS 36 4.27e-01 0.076500 7.84e-01
Metabolism of porphyrins 27 4.92e-01 -0.076400 8.17e-01
Resolution of D-Loop Structures 31 4.62e-01 0.076300 7.91e-01
Beta-oxidation of very long chain fatty acids 10 6.76e-01 -0.076300 9.06e-01
RHO GTPases Activate NADPH Oxidases 22 5.36e-01 -0.076200 8.36e-01
SUMOylation of RNA binding proteins 45 3.78e-01 -0.075900 7.51e-01
Transport of Mature mRNA Derived from an Intronless Transcript 40 4.06e-01 -0.075900 7.72e-01
Diseases associated with the TLR signaling cascade 29 4.79e-01 -0.075900 8.07e-01
Diseases of Immune System 29 4.79e-01 -0.075900 8.07e-01
Base Excision Repair 45 3.79e-01 0.075800 7.52e-01
Lagging Strand Synthesis 19 5.68e-01 0.075600 8.52e-01
Peroxisomal protein import 62 3.03e-01 0.075600 6.98e-01
Acyl chain remodelling of PG 18 5.80e-01 0.075300 8.56e-01
Signaling by EGFR 49 3.63e-01 0.075100 7.42e-01
CTNNB1 S33 mutants aren’t phosphorylated 14 6.27e-01 -0.075100 8.76e-01
CTNNB1 S37 mutants aren’t phosphorylated 14 6.27e-01 -0.075100 8.76e-01
CTNNB1 S45 mutants aren’t phosphorylated 14 6.27e-01 -0.075100 8.76e-01
CTNNB1 T41 mutants aren’t phosphorylated 14 6.27e-01 -0.075100 8.76e-01
Signaling by CTNNB1 phospho-site mutants 14 6.27e-01 -0.075100 8.76e-01
Signaling by GSK3beta mutants 14 6.27e-01 -0.075100 8.76e-01
Regulation of Expression and Function of Type II Classical Cadherins 31 4.70e-01 0.074900 7.99e-01
Regulation of Homotypic Cell-Cell Adhesion 31 4.70e-01 0.074900 7.99e-01
CaM pathway 33 4.57e-01 -0.074900 7.91e-01
Calmodulin induced events 33 4.57e-01 -0.074900 7.91e-01
Cellular response to chemical stress 207 6.32e-02 0.074800 3.35e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 95 2.08e-01 0.074800 5.96e-01
Regulation of PTEN stability and activity 66 2.94e-01 0.074600 6.92e-01
Class A/1 (Rhodopsin-like receptors) 311 2.38e-02 -0.074500 2.07e-01
Protein localization 147 1.20e-01 0.074300 4.52e-01
RHOH GTPase cycle 36 4.41e-01 -0.074300 7.84e-01
RNA Polymerase II Transcription 1282 7.13e-06 0.074300 3.23e-04
Downregulation of SMAD2/3:SMAD4 transcriptional activity 29 4.89e-01 0.074200 8.12e-01
Tight junction interactions 28 4.97e-01 -0.074100 8.17e-01
Signaling by NTRK1 (TRKA) 114 1.72e-01 0.074100 5.47e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 6.33e-01 0.073700 8.82e-01
Regulation of BACH1 activity 15 6.23e-01 0.073400 8.76e-01
Processing of Capped Intronless Pre-mRNA 28 5.02e-01 0.073200 8.18e-01
FCERI mediated NF-kB activation 77 2.66e-01 0.073200 6.68e-01
Glutathione conjugation 36 4.47e-01 0.073200 7.86e-01
Effects of PIP2 hydrolysis 26 5.19e-01 -0.073100 8.21e-01
Metabolism of non-coding RNA 50 3.71e-01 -0.073100 7.48e-01
snRNP Assembly 50 3.71e-01 -0.073100 7.48e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11 6.76e-01 0.072900 9.06e-01
Pyrimidine catabolism 12 6.62e-01 -0.072800 8.98e-01
Regulation of TP53 Activity 154 1.19e-01 0.072700 4.52e-01
Generic Transcription Pathway 1162 3.18e-05 0.072100 1.17e-03
Inactivation, recovery and regulation of the phototransduction cascade 31 4.88e-01 -0.072000 8.12e-01
Keratan sulfate biosynthesis 28 5.10e-01 -0.071900 8.19e-01
Asparagine N-linked glycosylation 296 3.38e-02 0.071700 2.52e-01
Aspartate and asparagine metabolism 11 6.81e-01 -0.071500 9.08e-01
Signaling by NOTCH1 70 3.01e-01 0.071400 6.96e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 5.46e-01 0.071200 8.40e-01
Toll Like Receptor 3 (TLR3) Cascade 99 2.22e-01 0.071000 6.11e-01
Transcriptional Regulation by VENTX 41 4.31e-01 0.071000 7.84e-01
NOTCH3 Intracellular Domain Regulates Transcription 24 5.47e-01 0.071000 8.40e-01
Purine ribonucleoside monophosphate biosynthesis 11 6.85e-01 0.070700 9.08e-01
Reduction of cytosolic Ca++ levels 11 6.85e-01 0.070700 9.08e-01
Macroautophagy 130 1.65e-01 0.070500 5.34e-01
Listeria monocytogenes entry into host cells 19 5.95e-01 0.070400 8.64e-01
Activation of G protein gated Potassium channels 29 5.12e-01 -0.070400 8.19e-01
G protein gated Potassium channels 29 5.12e-01 -0.070400 8.19e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 29 5.12e-01 -0.070400 8.19e-01
Eicosanoids 12 6.73e-01 0.070300 9.06e-01
EPHA-mediated growth cone collapse 29 5.13e-01 0.070200 8.20e-01
Nicotinamide salvaging 17 6.16e-01 0.070200 8.74e-01
Signaling by GPCR 671 1.97e-03 -0.069900 4.03e-02
Gene expression (Transcription) 1441 8.39e-06 0.069700 3.69e-04
Defective Intrinsic Pathway for Apoptosis 25 5.46e-01 0.069700 8.40e-01
Diseases associated with O-glycosylation of proteins 66 3.28e-01 0.069600 7.19e-01
Viral Infection Pathways 662 2.21e-03 0.069600 4.38e-02
G alpha (q) signalling events 206 8.50e-02 -0.069600 3.86e-01
Regulation of CDH11 function 10 7.04e-01 -0.069500 9.10e-01
Cargo recognition for clathrin-mediated endocytosis 98 2.34e-01 0.069500 6.25e-01
Thrombin signalling through proteinase activated receptors (PARs) 32 4.96e-01 -0.069500 8.17e-01
RHO GTPase Effectors 250 5.85e-02 0.069400 3.25e-01
Autophagy 144 1.50e-01 0.069400 5.06e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 37 4.66e-01 -0.069300 7.95e-01
Signaling by BRAF and RAF1 fusions 62 3.45e-01 -0.069300 7.29e-01
CTLA4 inhibitory signaling 21 5.83e-01 -0.069200 8.56e-01
Sensory processing of sound 71 3.14e-01 0.069100 7.04e-01
Signaling by Insulin receptor 80 2.86e-01 0.069000 6.89e-01
Adenylate cyclase activating pathway 10 7.07e-01 0.068700 9.10e-01
Signaling by FGFR4 in disease 11 6.94e-01 0.068500 9.09e-01
The phototransduction cascade 32 5.03e-01 -0.068400 8.18e-01
Transcriptional regulation by small RNAs 46 4.23e-01 0.068200 7.83e-01
Removal of the Flap Intermediate 13 6.71e-01 0.068000 9.06e-01
Transcriptional Regulation by E2F6 32 5.07e-01 -0.067800 8.18e-01
RHO GTPases Activate Formins 132 1.80e-01 0.067500 5.57e-01
HDACs deacetylate histones 29 5.30e-01 0.067400 8.31e-01
Interleukin-27 signaling 11 6.99e-01 -0.067300 9.10e-01
Cell Cycle 601 4.80e-03 0.067200 7.44e-02
RAB geranylgeranylation 57 3.80e-01 0.067200 7.52e-01
Regulated Necrosis 56 3.84e-01 -0.067200 7.54e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 29 5.31e-01 0.067200 8.31e-01
Defects in cobalamin (B12) metabolism 12 6.87e-01 0.067100 9.08e-01
Host Interactions of HIV factors 122 2.01e-01 0.066900 5.87e-01
Organic cation/anion/zwitterion transport 15 6.55e-01 0.066600 8.95e-01
Activated NTRK2 signals through FRS2 and FRS3 11 7.02e-01 -0.066600 9.10e-01
Potential therapeutics for SARS 92 2.70e-01 0.066500 6.72e-01
Adrenaline,noradrenaline inhibits insulin secretion 28 5.43e-01 0.066400 8.38e-01
ADORA2B mediated anti-inflammatory cytokines production 42 4.60e-01 -0.065800 7.91e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 4.51e-01 0.065700 7.88e-01
Regulation of PLK1 Activity at G2/M Transition 83 3.01e-01 0.065600 6.96e-01
Mucopolysaccharidoses 10 7.21e-01 0.065200 9.11e-01
Formation of the beta-catenin:TCF transactivating complex 32 5.24e-01 0.065200 8.24e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 30 5.38e-01 0.064900 8.36e-01
PCP/CE pathway 90 2.87e-01 0.064900 6.89e-01
Hedgehog ‘off’ state 110 2.40e-01 0.064900 6.33e-01
Export of Viral Ribonucleoproteins from Nucleus 31 5.32e-01 -0.064900 8.31e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 30 5.39e-01 -0.064900 8.36e-01
Inositol phosphate metabolism 45 4.53e-01 0.064600 7.90e-01
Regulation of beta-cell development 41 4.74e-01 0.064600 8.02e-01
Degradation of beta-catenin by the destruction complex 81 3.16e-01 0.064500 7.04e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 27 5.63e-01 -0.064400 8.48e-01
p75 NTR receptor-mediated signalling 90 2.92e-01 0.064200 6.91e-01
Complex I biogenesis 49 4.37e-01 0.064100 7.84e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 12 7.01e-01 -0.064000 9.10e-01
ATF4 activates genes in response to endoplasmic reticulum stress 28 5.58e-01 0.063900 8.46e-01
Disorders of Developmental Biology 11 7.14e-01 0.063800 9.11e-01
Disorders of Nervous System Development 11 7.14e-01 0.063800 9.11e-01
Loss of function of MECP2 in Rett syndrome 11 7.14e-01 0.063800 9.11e-01
Pervasive developmental disorders 11 7.14e-01 0.063800 9.11e-01
Antiviral mechanism by IFN-stimulated genes 143 1.88e-01 0.063700 5.66e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 41 4.80e-01 -0.063700 8.07e-01
Nephrin family interactions 22 6.05e-01 -0.063600 8.66e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 35 5.15e-01 0.063600 8.20e-01
Signaling by Nuclear Receptors 238 9.12e-02 0.063500 3.94e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 106 2.59e-01 0.063500 6.56e-01
Toll Like Receptor TLR6:TLR2 Cascade 106 2.59e-01 0.063500 6.56e-01
Transport of the SLBP Dependant Mature mRNA 34 5.23e-01 -0.063300 8.23e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 7.30e-01 0.062900 9.14e-01
TCF dependent signaling in response to WNT 168 1.60e-01 0.062800 5.24e-01
Signaling by FGFR3 in disease 21 6.18e-01 0.062800 8.76e-01
Factors involved in megakaryocyte development and platelet production 147 1.89e-01 -0.062800 5.66e-01
Thyroxine biosynthesis 10 7.31e-01 -0.062700 9.14e-01
MAPK targets/ Nuclear events mediated by MAP kinases 29 5.61e-01 0.062300 8.48e-01
Hemostasis 575 1.07e-02 -0.062200 1.30e-01
Endogenous sterols 26 5.84e-01 0.062100 8.56e-01
PKA-mediated phosphorylation of CREB 19 6.39e-01 -0.062100 8.85e-01
G-protein mediated events 52 4.40e-01 -0.061900 7.84e-01
DARPP-32 events 24 6.00e-01 0.061800 8.66e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 15 6.79e-01 0.061800 9.08e-01
Post-translational modification: synthesis of GPI-anchored proteins 89 3.14e-01 0.061800 7.04e-01
RUNX3 regulates NOTCH signaling 13 7.00e-01 0.061700 9.10e-01
Clathrin-mediated endocytosis 137 2.12e-01 0.061700 5.99e-01
O-linked glycosylation of mucins 62 4.04e-01 -0.061200 7.71e-01
Diseases associated with visual transduction 11 7.25e-01 -0.061200 9.11e-01
Diseases of the neuronal system 11 7.25e-01 -0.061200 9.11e-01
Retinoid cycle disease events 11 7.25e-01 -0.061200 9.11e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 43 4.88e-01 0.061200 8.12e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 13 7.03e-01 0.061200 9.10e-01
Signaling by Hedgehog 146 2.02e-01 0.061100 5.87e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 21 6.28e-01 0.061100 8.77e-01
Downstream signaling of activated FGFR2 29 5.70e-01 0.060900 8.52e-01
Post-translational protein phosphorylation 100 2.94e-01 -0.060700 6.92e-01
Constitutive Signaling by Aberrant PI3K in Cancer 77 3.58e-01 -0.060600 7.40e-01
MAP kinase activation 58 4.25e-01 0.060600 7.83e-01
Nuclear events stimulated by ALK signaling in cancer 18 6.57e-01 -0.060500 8.95e-01
Presynaptic phase of homologous DNA pairing and strand exchange 38 5.19e-01 0.060500 8.21e-01
RAB GEFs exchange GTP for GDP on RABs 82 3.45e-01 -0.060400 7.29e-01
Signaling by the B Cell Receptor (BCR) 105 2.86e-01 0.060300 6.89e-01
Peptide ligand-binding receptors 190 1.52e-01 -0.060200 5.08e-01
Transcriptional activation of mitochondrial biogenesis 51 4.58e-01 0.060100 7.91e-01
ER to Golgi Anterograde Transport 152 2.04e-01 0.059700 5.89e-01
Digestion and absorption 23 6.21e-01 -0.059600 8.76e-01
Regulation of KIT signaling 16 6.81e-01 -0.059300 9.08e-01
Cell death signalling via NRAGE, NRIF and NADE 69 3.97e-01 0.058900 7.65e-01
Toll Like Receptor 9 (TLR9) Cascade 100 3.09e-01 0.058900 7.00e-01
PECAM1 interactions 12 7.24e-01 -0.058800 9.11e-01
Extra-nuclear estrogen signaling 74 3.83e-01 0.058600 7.54e-01
Neutrophil degranulation 456 3.18e-02 -0.058600 2.45e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 7.05e-01 0.058400 9.10e-01
Signal amplification 33 5.62e-01 -0.058300 8.48e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 89 3.42e-01 0.058300 7.26e-01
Amplification of signal from the kinetochores 89 3.42e-01 0.058300 7.26e-01
Metabolism of steroids 148 2.22e-01 -0.058100 6.11e-01
Cellular hexose transport 21 6.45e-01 0.058000 8.90e-01
Metabolism of vitamins and cofactors 184 1.75e-01 0.058000 5.50e-01
Metabolism 1969 1.98e-05 0.057800 8.48e-04
Diseases of glycosylation 137 2.43e-01 0.057700 6.37e-01
Chondroitin sulfate biosynthesis 18 6.73e-01 -0.057500 9.06e-01
FCGR3A-mediated IL10 synthesis 37 5.47e-01 -0.057300 8.40e-01
M Phase 335 7.13e-02 0.057300 3.49e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 21 6.50e-01 0.057200 8.92e-01
GAB1 signalosome 17 6.85e-01 0.056900 9.08e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 7.44e-01 0.056900 9.18e-01
Mismatch Repair 15 7.03e-01 0.056800 9.10e-01
Signaling by ERBB4 57 4.58e-01 0.056800 7.91e-01
Mitochondrial biogenesis 69 4.16e-01 0.056600 7.80e-01
The role of Nef in HIV-1 replication and disease pathogenesis 27 6.11e-01 0.056500 8.70e-01
Activation of the pre-replicative complex 31 5.86e-01 -0.056400 8.59e-01
Glucose metabolism 89 3.58e-01 0.056400 7.40e-01
Signaling by PDGFRA extracellular domain mutants 12 7.35e-01 -0.056300 9.16e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 7.35e-01 -0.056300 9.16e-01
Norepinephrine Neurotransmitter Release Cycle 16 6.97e-01 0.056300 9.09e-01
Trafficking of GluR2-containing AMPA receptors 15 7.07e-01 -0.056100 9.10e-01
Bicarbonate transporters 10 7.59e-01 -0.056100 9.22e-01
Amyloid fiber formation 53 4.82e-01 0.055900 8.07e-01
Signaling by ALK 26 6.22e-01 0.055900 8.76e-01
Signaling by Erythropoietin 25 6.29e-01 -0.055900 8.77e-01
Synthesis of PIPs at the plasma membrane 48 5.04e-01 -0.055700 8.18e-01
Creation of C4 and C2 activators 14 7.18e-01 0.055700 9.11e-01
Regulation of actin dynamics for phagocytic cup formation 59 4.61e-01 0.055400 7.91e-01
Platelet activation, signaling and aggregation 247 1.34e-01 -0.055300 4.83e-01
Mitochondrial calcium ion transport 22 6.54e-01 -0.055200 8.94e-01
FRS-mediated FGFR2 signaling 24 6.40e-01 0.055200 8.85e-01
Defective GALNT3 causes HFTC 18 6.86e-01 0.055000 9.08e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 20 6.71e-01 -0.054900 9.06e-01
Acetylcholine binding and downstream events 14 7.22e-01 0.054900 9.11e-01
Postsynaptic nicotinic acetylcholine receptors 14 7.22e-01 0.054900 9.11e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 12 7.42e-01 0.054900 9.18e-01
Defective EXT2 causes exostoses 2 12 7.42e-01 0.054900 9.18e-01
Nuclear Envelope Breakdown 50 5.03e-01 -0.054700 8.18e-01
Cell Cycle, Mitotic 476 4.09e-02 0.054600 2.83e-01
Antigen processing-Cross presentation 100 3.46e-01 0.054500 7.29e-01
Signaling by NTRKs 133 2.77e-01 0.054500 6.81e-01
PKMTs methylate histone lysines 36 5.73e-01 -0.054300 8.53e-01
ALK mutants bind TKIs 12 7.45e-01 -0.054300 9.18e-01
PI-3K cascade:FGFR2 22 6.59e-01 0.054300 8.96e-01
COPI-mediated anterograde transport 101 3.47e-01 0.054200 7.29e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 16 7.08e-01 0.054100 9.10e-01
HDR through MMEJ (alt-NHEJ) 11 7.56e-01 -0.054000 9.21e-01
Extension of Telomeres 48 5.20e-01 0.053700 8.21e-01
SLC-mediated transmembrane transport 236 1.56e-01 0.053600 5.17e-01
Processing and activation of SUMO 10 7.70e-01 0.053500 9.27e-01
Cargo concentration in the ER 32 6.01e-01 0.053400 8.66e-01
Protein folding 94 3.73e-01 -0.053200 7.48e-01
Vasopressin regulates renal water homeostasis via Aquaporins 42 5.52e-01 -0.053000 8.43e-01
EPH-Ephrin signaling 90 3.86e-01 0.052900 7.55e-01
Adaptive Immune System 733 1.46e-02 -0.052800 1.55e-01
Integration of energy metabolism 105 3.51e-01 0.052600 7.34e-01
Unblocking of NMDA receptors, glutamate binding and activation 19 6.91e-01 -0.052600 9.08e-01
Post-chaperonin tubulin folding pathway 23 6.63e-01 -0.052400 8.99e-01
Response of Mtb to phagocytosis 22 6.72e-01 0.052200 9.06e-01
Formation of apoptosome 10 7.75e-01 -0.052200 9.27e-01
Regulation of the apoptosome activity 10 7.75e-01 -0.052200 9.27e-01
Transport of Mature Transcript to Cytoplasm 76 4.32e-01 0.052200 7.84e-01
Toll Like Receptor 2 (TLR2) Cascade 109 3.51e-01 0.051700 7.34e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 3.51e-01 0.051700 7.34e-01
Apoptotic factor-mediated response 17 7.13e-01 -0.051600 9.11e-01
IKK complex recruitment mediated by RIP1 22 6.75e-01 -0.051600 9.06e-01
Cardiogenesis 25 6.57e-01 0.051300 8.95e-01
WNT5A-dependent internalization of FZD4 15 7.31e-01 -0.051200 9.14e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 7.59e-01 0.051000 9.22e-01
COPI-dependent Golgi-to-ER retrograde traffic 99 3.81e-01 0.050900 7.52e-01
Downstream TCR signaling 92 3.99e-01 0.050900 7.66e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 67 4.72e-01 0.050800 8.01e-01
Signaling by TGFB family members 121 3.36e-01 0.050600 7.26e-01
Infectious disease 848 1.22e-02 0.050500 1.40e-01
Cyclin A/B1/B2 associated events during G2/M transition 24 6.69e-01 0.050500 9.05e-01
Ras activation upon Ca2+ influx through NMDA receptor 19 7.05e-01 0.050100 9.10e-01
Downstream signaling of activated FGFR4 26 6.59e-01 0.050000 8.96e-01
Elevation of cytosolic Ca2+ levels 16 7.29e-01 -0.050000 9.14e-01
Transcriptional regulation of pluripotent stem cells 30 6.36e-01 0.050000 8.84e-01
Metabolism of carbohydrates 281 1.50e-01 0.049900 5.06e-01
GABA receptor activation 57 5.16e-01 -0.049800 8.21e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 6.40e-01 -0.049300 8.85e-01
Immune System 1921 3.52e-04 -0.048900 1.05e-02
Phase I - Functionalization of compounds 100 3.98e-01 0.048900 7.65e-01
RHO GTPase cycle 419 8.88e-02 -0.048400 3.90e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 43 5.83e-01 -0.048300 8.56e-01
Signaling by RAS mutants 43 5.83e-01 -0.048300 8.56e-01
Signaling by moderate kinase activity BRAF mutants 43 5.83e-01 -0.048300 8.56e-01
Signaling downstream of RAS mutants 43 5.83e-01 -0.048300 8.56e-01
RHOBTB GTPase Cycle 34 6.27e-01 -0.048100 8.76e-01
Signaling by VEGF 103 4.00e-01 0.048000 7.66e-01
Visual phototransduction 93 4.24e-01 0.047900 7.83e-01
Signaling by Receptor Tyrosine Kinases 511 6.42e-02 0.047800 3.37e-01
Nuclear Envelope (NE) Reassembly 73 4.83e-01 0.047500 8.07e-01
CS/DS degradation 12 7.76e-01 0.047500 9.27e-01
Signal transduction by L1 20 7.16e-01 0.047100 9.11e-01
SUMOylation of transcription cofactors 43 5.98e-01 0.046400 8.65e-01
STING mediated induction of host immune responses 13 7.73e-01 -0.046300 9.27e-01
Regulation of lipid metabolism by PPARalpha 116 3.89e-01 0.046300 7.61e-01
Golgi-to-ER retrograde transport 133 3.58e-01 0.046200 7.40e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 22 7.08e-01 0.046100 9.10e-01
Neurodegenerative Diseases 22 7.08e-01 0.046100 9.10e-01
Platelet homeostasis 85 4.62e-01 -0.046100 7.91e-01
Condensation of Prophase Chromosomes 12 7.82e-01 -0.046100 9.30e-01
Nuclear import of Rev protein 32 6.53e-01 -0.045900 8.94e-01
NRAGE signals death through JNK 53 5.64e-01 -0.045900 8.48e-01
Reproduction 94 4.44e-01 -0.045700 7.84e-01
Activation of Matrix Metalloproteinases 31 6.60e-01 0.045600 8.96e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 117 3.96e-01 -0.045400 7.65e-01
Metabolism of proteins 1777 1.40e-03 0.045300 3.12e-02
GABA synthesis, release, reuptake and degradation 19 7.33e-01 0.045300 9.15e-01
Stimuli-sensing channels 101 4.33e-01 0.045100 7.84e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 12 7.87e-01 0.045000 9.30e-01
Mitotic G2-G2/M phases 191 2.85e-01 0.044800 6.89e-01
Innate Immune System 999 1.66e-02 -0.044600 1.69e-01
G2/M Transition 189 2.91e-01 0.044600 6.91e-01
Negative regulation of MAPK pathway 41 6.24e-01 0.044300 8.76e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 29 6.80e-01 0.044300 9.08e-01
Trafficking of AMPA receptors 29 6.80e-01 0.044300 9.08e-01
Cell junction organization 107 4.32e-01 0.044000 7.84e-01
Sensory processing of sound by outer hair cells of the cochlea 51 5.89e-01 0.043800 8.60e-01
G alpha (12/13) signalling events 74 5.17e-01 -0.043600 8.21e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 37 6.47e-01 -0.043500 8.90e-01
Activation of the phototransduction cascade 11 8.03e-01 0.043400 9.30e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 25 7.08e-01 0.043300 9.10e-01
Collagen degradation 61 5.64e-01 -0.042700 8.48e-01
PPARA activates gene expression 114 4.31e-01 0.042700 7.84e-01
RAF activation 33 6.72e-01 0.042600 9.06e-01
Formation of definitive endoderm 15 7.76e-01 0.042500 9.27e-01
Arachidonic acid metabolism 56 5.83e-01 0.042500 8.56e-01
Protein-protein interactions at synapses 78 5.17e-01 0.042400 8.21e-01
Resolution of Sister Chromatid Cohesion 116 4.31e-01 0.042300 7.84e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 12 8.00e-01 -0.042200 9.30e-01
Synthesis of PIPs at the Golgi membrane 17 7.64e-01 -0.042100 9.26e-01
Chaperonin-mediated protein folding 88 4.96e-01 -0.042000 8.17e-01
RIPK1-mediated regulated necrosis 30 6.91e-01 0.041900 9.08e-01
Regulation of necroptotic cell death 30 6.91e-01 0.041900 9.08e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 7.94e-01 0.041800 9.30e-01
Disease 1584 5.35e-03 0.041700 7.94e-02
TP53 Regulates Transcription of Cell Death Genes 42 6.40e-01 -0.041700 8.85e-01
MASTL Facilitates Mitotic Progression 10 8.20e-01 0.041500 9.36e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 7.96e-01 -0.041300 9.30e-01
Signaling by RAF1 mutants 39 6.57e-01 -0.041100 8.95e-01
CD28 co-stimulation 32 6.88e-01 -0.041000 9.08e-01
FRS-mediated FGFR4 signaling 21 7.45e-01 0.040900 9.18e-01
Oncogenic MAPK signaling 78 5.32e-01 -0.040900 8.31e-01
NFE2L2 regulating tumorigenic genes 11 8.14e-01 0.040900 9.33e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 6.10e-01 0.040900 8.70e-01
Meiotic synapsis 32 6.90e-01 0.040700 9.08e-01
Insulin receptor signalling cascade 53 6.08e-01 0.040700 8.68e-01
Peroxisomal lipid metabolism 28 7.09e-01 0.040700 9.11e-01
Ca2+ pathway 62 5.80e-01 -0.040600 8.56e-01
PIP3 activates AKT signaling 276 2.47e-01 0.040500 6.43e-01
Nuclear signaling by ERBB4 32 6.92e-01 -0.040400 9.08e-01
Paracetamol ADME 27 7.16e-01 -0.040400 9.11e-01
Phospholipid metabolism 192 3.35e-01 0.040300 7.26e-01
Postmitotic nuclear pore complex (NPC) reformation 26 7.22e-01 0.040300 9.11e-01
Blood group systems biosynthesis 22 7.44e-01 -0.040200 9.18e-01
TNFR1-induced proapoptotic signaling 24 7.33e-01 0.040200 9.15e-01
Meiosis 56 6.03e-01 -0.040200 8.66e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 32 6.95e-01 0.040000 9.09e-01
Rev-mediated nuclear export of HIV RNA 33 6.92e-01 -0.039800 9.08e-01
Defective GALNT12 causes CRCS1 18 7.70e-01 0.039700 9.27e-01
Formation of the cornified envelope 127 4.41e-01 -0.039600 7.84e-01
FLT3 Signaling 38 6.73e-01 -0.039500 9.06e-01
Interaction between L1 and Ankyrins 30 7.08e-01 0.039500 9.10e-01
Negative regulation of the PI3K/AKT network 111 4.72e-01 -0.039500 8.01e-01
Phase II - Conjugation of compounds 106 4.82e-01 -0.039500 8.07e-01
Anti-inflammatory response favouring Leishmania parasite infection 75 5.55e-01 -0.039400 8.43e-01
Leishmania parasite growth and survival 75 5.55e-01 -0.039400 8.43e-01
Biotin transport and metabolism 10 8.30e-01 0.039300 9.40e-01
Heme biosynthesis 13 8.06e-01 -0.039300 9.30e-01
Nucleotide catabolism 35 6.90e-01 0.039000 9.08e-01
PKA activation 18 7.76e-01 -0.038700 9.27e-01
Costimulation by the CD28 family 65 5.91e-01 -0.038500 8.62e-01
Fatty acid metabolism 168 3.90e-01 0.038400 7.62e-01
APC truncation mutants have impaired AXIN binding 13 8.11e-01 -0.038400 9.30e-01
AXIN missense mutants destabilize the destruction complex 13 8.11e-01 -0.038400 9.30e-01
Signaling by AMER1 mutants 13 8.11e-01 -0.038400 9.30e-01
Signaling by APC mutants 13 8.11e-01 -0.038400 9.30e-01
Signaling by AXIN mutants 13 8.11e-01 -0.038400 9.30e-01
Truncations of AMER1 destabilize the destruction complex 13 8.11e-01 -0.038400 9.30e-01
Purine catabolism 17 7.84e-01 0.038400 9.30e-01
PI-3K cascade:FGFR4 19 7.72e-01 0.038300 9.27e-01
Interleukin-17 signaling 66 5.90e-01 0.038300 8.61e-01
Response to metal ions 14 8.04e-01 -0.038300 9.30e-01
Transcriptional regulation of white adipocyte differentiation 81 5.53e-01 0.038100 8.43e-01
ER-Phagosome pathway 87 5.40e-01 0.038000 8.37e-01
Regulation of insulin secretion 77 5.69e-01 0.037500 8.52e-01
HS-GAG biosynthesis 28 7.32e-01 0.037400 9.14e-01
Opioid Signalling 88 5.45e-01 -0.037300 8.40e-01
Regulation of RUNX1 Expression and Activity 25 7.47e-01 -0.037300 9.19e-01
Extracellular matrix organization 292 2.74e-01 0.037200 6.75e-01
tRNA processing in the nucleus 55 6.34e-01 0.037100 8.82e-01
Hyaluronan uptake and degradation 12 8.24e-01 0.037100 9.37e-01
Golgi Associated Vesicle Biogenesis 51 6.48e-01 -0.036900 8.90e-01
ECM proteoglycans 73 5.87e-01 -0.036800 8.59e-01
RHOF GTPase cycle 40 6.88e-01 -0.036700 9.08e-01
VEGFA-VEGFR2 Pathway 95 5.38e-01 0.036600 8.36e-01
Signaling by MET 78 5.78e-01 0.036400 8.56e-01
Chromatin modifying enzymes 185 3.96e-01 0.036200 7.65e-01
Chromatin organization 185 3.96e-01 0.036200 7.65e-01
Glucagon signaling in metabolic regulation 32 7.23e-01 -0.036200 9.11e-01
Sialic acid metabolism 33 7.20e-01 -0.036100 9.11e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 12 8.29e-01 -0.036100 9.39e-01
Class B/2 (Secretin family receptors) 93 5.48e-01 0.036000 8.41e-01
Serotonin Neurotransmitter Release Cycle 16 8.05e-01 0.035700 9.30e-01
Transport of small molecules 694 1.10e-01 0.035500 4.30e-01
G alpha (s) signalling events 154 4.47e-01 -0.035500 7.86e-01
Amine ligand-binding receptors 41 6.95e-01 0.035400 9.09e-01
Prefoldin mediated transfer of substrate to CCT/TriC 27 7.50e-01 0.035400 9.20e-01
Interferon alpha/beta signaling 74 5.99e-01 -0.035300 8.65e-01
Circadian Clock 69 6.12e-01 0.035300 8.70e-01
Hyaluronan metabolism 17 8.02e-01 0.035200 9.30e-01
TRP channels 27 7.54e-01 0.034800 9.20e-01
Death Receptor Signaling 143 4.73e-01 0.034800 8.01e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 8.50e-01 0.034600 9.51e-01
Pre-NOTCH Transcription and Translation 45 6.89e-01 0.034500 9.08e-01
Assembly and cell surface presentation of NMDA receptors 41 7.02e-01 -0.034500 9.10e-01
Centrosome maturation 76 6.05e-01 -0.034300 8.66e-01
Recruitment of mitotic centrosome proteins and complexes 76 6.05e-01 -0.034300 8.66e-01
tRNA Aminoacylation 24 7.72e-01 -0.034200 9.27e-01
Platelet sensitization by LDL 17 8.07e-01 -0.034100 9.30e-01
Endosomal/Vacuolar pathway 12 8.40e-01 0.033600 9.45e-01
RAF-independent MAPK1/3 activation 22 7.87e-01 0.033300 9.30e-01
Synthesis, secretion, and deacylation of Ghrelin 19 8.01e-01 0.033300 9.30e-01
Oxidative Stress Induced Senescence 66 6.40e-01 -0.033200 8.85e-01
Repression of WNT target genes 13 8.36e-01 0.033200 9.43e-01
Processing of Intronless Pre-mRNAs 19 8.03e-01 0.033000 9.30e-01
Signaling by FGFR in disease 61 6.57e-01 0.032900 8.95e-01
Mitochondrial tRNA aminoacylation 18 8.10e-01 0.032700 9.30e-01
Diseases of DNA repair 49 6.92e-01 0.032700 9.08e-01
G alpha (z) signalling events 48 6.97e-01 -0.032500 9.09e-01
RHOC GTPase cycle 69 6.41e-01 -0.032400 8.86e-01
Membrane Trafficking 605 1.74e-01 0.032300 5.50e-01
Signaling by Hippo 19 8.09e-01 -0.032100 9.30e-01
Transport of connexons to the plasma membrane 20 8.04e-01 -0.032000 9.30e-01
Transcriptional regulation by RUNX1 182 4.60e-01 0.031700 7.91e-01
HDR through Single Strand Annealing (SSA) 36 7.42e-01 0.031700 9.18e-01
Glycolysis 70 6.48e-01 0.031500 8.90e-01
Developmental Biology 1158 6.99e-02 0.031500 3.43e-01
Glycogen breakdown (glycogenolysis) 11 8.57e-01 0.031400 9.52e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 8.13e-01 0.031300 9.32e-01
Deposition of new CENPA-containing nucleosomes at the centromere 26 7.82e-01 0.031300 9.30e-01
Nucleosome assembly 26 7.82e-01 0.031300 9.30e-01
Acetylcholine Neurotransmitter Release Cycle 16 8.28e-01 0.031300 9.39e-01
SLC transporter disorders 92 6.12e-01 0.030600 8.70e-01
C-type lectin receptors (CLRs) 137 5.37e-01 0.030500 8.36e-01
PERK regulates gene expression 32 7.67e-01 0.030200 9.27e-01
Interleukin-6 family signaling 24 7.98e-01 -0.030100 9.30e-01
Cholesterol biosynthesis 24 7.99e-01 -0.030000 9.30e-01
SARS-CoV Infections 386 3.11e-01 0.030000 7.00e-01
Serotonin receptors 11 8.63e-01 -0.030000 9.52e-01
Notch-HLH transcription pathway 24 7.99e-01 -0.030000 9.30e-01
Negative regulation of FLT3 15 8.42e-01 0.029700 9.47e-01
Diseases associated with glycosaminoglycan metabolism 38 7.52e-01 -0.029600 9.20e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 8.60e-01 0.029500 9.52e-01
alpha-linolenic acid (ALA) metabolism 12 8.60e-01 0.029500 9.52e-01
Synthesis of very long-chain fatty acyl-CoAs 23 8.07e-01 -0.029400 9.30e-01
tRNA modification in the nucleus and cytosol 38 7.55e-01 -0.029300 9.20e-01
Pyruvate metabolism 29 7.86e-01 -0.029100 9.30e-01
Nonhomologous End-Joining (NHEJ) 32 7.76e-01 0.029000 9.27e-01
RHOB GTPase cycle 66 6.84e-01 -0.029000 9.08e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 8.52e-01 0.028700 9.51e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 45 7.39e-01 0.028700 9.18e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 27 7.97e-01 -0.028700 9.30e-01
Ovarian tumor domain proteases 35 7.69e-01 -0.028600 9.27e-01
Retrograde neurotrophin signalling 14 8.53e-01 -0.028600 9.51e-01
Neuronal System 389 3.35e-01 0.028400 7.26e-01
Intrinsic Pathway for Apoptosis 52 7.25e-01 0.028200 9.11e-01
Neurotransmitter receptors and postsynaptic signal transmission 193 5.01e-01 -0.028100 8.18e-01
Nicotinate metabolism 29 7.94e-01 0.028000 9.30e-01
Cargo trafficking to the periciliary membrane 49 7.35e-01 -0.027900 9.16e-01
The NLRP3 inflammasome 16 8.47e-01 -0.027900 9.51e-01
The canonical retinoid cycle in rods (twilight vision) 23 8.17e-01 0.027900 9.35e-01
Adherens junctions interactions 52 7.28e-01 0.027900 9.14e-01
MyD88-independent TLR4 cascade 103 6.27e-01 0.027700 8.76e-01
TRIF(TICAM1)-mediated TLR4 signaling 103 6.27e-01 0.027700 8.76e-01
Signaling by WNT 263 4.39e-01 0.027700 7.84e-01
trans-Golgi Network Vesicle Budding 67 6.97e-01 -0.027500 9.09e-01
Viral Messenger RNA Synthesis 42 7.58e-01 0.027400 9.22e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 8.81e-01 -0.027400 9.56e-01
Glucagon-type ligand receptors 32 7.89e-01 0.027400 9.30e-01
Signaling by PDGF 57 7.22e-01 -0.027200 9.11e-01
Rap1 signalling 16 8.51e-01 0.027100 9.51e-01
SUMOylation of SUMOylation proteins 33 7.88e-01 -0.027100 9.30e-01
Semaphorin interactions 61 7.15e-01 0.027100 9.11e-01
SUMOylation of DNA methylation proteins 16 8.54e-01 -0.026600 9.51e-01
Interleukin-1 family signaling 145 5.80e-01 0.026600 8.56e-01
Platelet degranulation 115 6.23e-01 -0.026500 8.76e-01
Cilium Assembly 185 5.38e-01 -0.026300 8.36e-01
Leishmania infection 157 5.71e-01 -0.026200 8.52e-01
Parasitic Infection Pathways 157 5.71e-01 -0.026200 8.52e-01
Crosslinking of collagen fibrils 16 8.56e-01 0.026100 9.52e-01
PI Metabolism 79 6.88e-01 -0.026100 9.08e-01
Ephrin signaling 17 8.53e-01 0.026000 9.51e-01
Aquaporin-mediated transport 51 7.48e-01 -0.026000 9.19e-01
EML4 and NUDC in mitotic spindle formation 111 6.39e-01 0.025800 8.85e-01
RND2 GTPase cycle 41 7.75e-01 -0.025800 9.27e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 53 7.46e-01 0.025700 9.19e-01
Intracellular signaling by second messengers 314 4.33e-01 0.025700 7.84e-01
Regulation of IFNG signaling 14 8.69e-01 0.025500 9.52e-01
Physiological factors 14 8.70e-01 0.025300 9.52e-01
Anchoring of the basal body to the plasma membrane 92 6.76e-01 -0.025200 9.06e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 8.49e-01 -0.025200 9.51e-01
Deadenylation-dependent mRNA decay 53 7.53e-01 0.025000 9.20e-01
SUMOylation 165 5.80e-01 -0.024900 8.56e-01
RHO GTPases Activate WASPs and WAVEs 34 8.03e-01 0.024700 9.30e-01
Post-translational protein modification 1313 1.31e-01 0.024700 4.76e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 52 7.59e-01 0.024600 9.22e-01
Interactions of Rev with host cellular proteins 35 8.01e-01 -0.024600 9.30e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 19 8.53e-01 -0.024500 9.51e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 8.74e-01 0.024500 9.54e-01
Integrin signaling 27 8.26e-01 -0.024500 9.38e-01
Recycling pathway of L1 43 7.82e-01 -0.024400 9.30e-01
Response to elevated platelet cytosolic Ca2+ 120 6.47e-01 -0.024200 8.90e-01
Interferon gamma signaling 93 6.87e-01 -0.024200 9.08e-01
DSCAM interactions 11 8.90e-01 -0.024100 9.62e-01
RUNX2 regulates bone development 29 8.23e-01 0.024000 9.37e-01
FCGR3A-mediated phagocytosis 57 7.55e-01 0.023900 9.20e-01
Leishmania phagocytosis 57 7.55e-01 0.023900 9.20e-01
Parasite infection 57 7.55e-01 0.023900 9.20e-01
SUMOylation of DNA replication proteins 44 7.84e-01 0.023900 9.30e-01
Digestion 18 8.61e-01 -0.023800 9.52e-01
HDMs demethylate histones 18 8.64e-01 -0.023400 9.52e-01
PD-1 signaling 21 8.55e-01 0.023100 9.51e-01
Anchoring fibril formation 13 8.86e-01 0.022900 9.61e-01
Bacterial Infection Pathways 68 7.44e-01 0.022900 9.18e-01
Processing of SMDT1 15 8.78e-01 -0.022800 9.56e-01
Sphingolipid metabolism 83 7.19e-01 -0.022800 9.11e-01
Downstream signal transduction 29 8.31e-01 0.022800 9.41e-01
Transport to the Golgi and subsequent modification 183 5.95e-01 0.022800 8.64e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 8.75e-01 -0.022700 9.55e-01
Vitamin D (calciferol) metabolism 12 8.92e-01 -0.022700 9.62e-01
Carnitine metabolism 13 8.89e-01 0.022400 9.62e-01
IGF1R signaling cascade 51 7.83e-01 0.022300 9.30e-01
Glycosphingolipid metabolism 42 8.06e-01 0.021900 9.30e-01
Aflatoxin activation and detoxification 19 8.69e-01 0.021800 9.52e-01
TRAF6 mediated NF-kB activation 23 8.57e-01 0.021800 9.52e-01
ZBP1(DAI) mediated induction of type I IFNs 20 8.66e-01 -0.021700 9.52e-01
Vesicle-mediated transport 643 3.46e-01 0.021700 7.29e-01
Neurexins and neuroligins 52 7.87e-01 -0.021700 9.30e-01
Activation of ATR in response to replication stress 37 8.21e-01 0.021500 9.37e-01
SUMO E3 ligases SUMOylate target proteins 159 6.40e-01 -0.021500 8.85e-01
Fcgamma receptor (FCGR) dependent phagocytosis 82 7.38e-01 0.021400 9.17e-01
Chondroitin sulfate/dermatan sulfate metabolism 45 8.05e-01 0.021200 9.30e-01
Translocation of ZAP-70 to Immunological synapse 17 8.80e-01 -0.021200 9.56e-01
GPER1 signaling 45 8.07e-01 0.021000 9.30e-01
Pre-NOTCH Expression and Processing 61 7.78e-01 0.020900 9.28e-01
PI3K/AKT Signaling in Cancer 103 7.14e-01 -0.020900 9.11e-01
Collagen biosynthesis and modifying enzymes 65 7.71e-01 0.020900 9.27e-01
Gastrin-CREB signalling pathway via PKC and MAPK 17 8.82e-01 0.020700 9.57e-01
Collagen formation 88 7.37e-01 0.020700 9.17e-01
Collagen chain trimerization 42 8.20e-01 -0.020300 9.36e-01
Telomere Extension By Telomerase 22 8.70e-01 0.020200 9.52e-01
NR1H2 and NR1H3-mediated signaling 53 7.99e-01 0.020200 9.30e-01
IRS-related events triggered by IGF1R 50 8.05e-01 0.020200 9.30e-01
Signaling by Retinoic Acid 41 8.23e-01 0.020200 9.37e-01
Non-integrin membrane-ECM interactions 55 7.96e-01 0.020100 9.30e-01
Interleukin-12 family signaling 53 8.00e-01 -0.020100 9.30e-01
Rab regulation of trafficking 113 7.13e-01 0.020100 9.11e-01
SLBP independent Processing of Histone Pre-mRNAs 10 9.13e-01 0.020000 9.69e-01
SARS-CoV-1 activates/modulates innate immune responses 36 8.36e-01 0.020000 9.43e-01
Long-term potentiation 22 8.71e-01 -0.020000 9.52e-01
Growth hormone receptor signaling 24 8.68e-01 0.019700 9.52e-01
Defects in vitamin and cofactor metabolism 20 8.81e-01 0.019400 9.56e-01
SARS-CoV-2-host interactions 185 6.51e-01 0.019200 8.93e-01
PKA activation in glucagon signalling 17 8.91e-01 0.019200 9.62e-01
HCMV Late Events 54 8.07e-01 -0.019200 9.30e-01
Beta-catenin independent WNT signaling 144 6.94e-01 0.019000 9.09e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 15 9.01e-01 -0.018600 9.65e-01
Integrin cell surface interactions 83 7.70e-01 -0.018500 9.27e-01
FGFR2b ligand binding and activation 10 9.20e-01 0.018400 9.69e-01
Early SARS-CoV-2 Infection Events 34 8.54e-01 0.018200 9.51e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 104 7.50e-01 -0.018100 9.20e-01
Basigin interactions 24 8.80e-01 0.017900 9.56e-01
Metalloprotease DUBs 19 8.95e-01 0.017500 9.62e-01
Nucleotide-like (purinergic) receptors 13 9.13e-01 -0.017400 9.69e-01
RND1 GTPase cycle 41 8.48e-01 -0.017300 9.51e-01
Late SARS-CoV-2 Infection Events 67 8.07e-01 0.017300 9.30e-01
Dermatan sulfate biosynthesis 10 9.25e-01 0.017300 9.69e-01
Translation of Structural Proteins 9694635 55 8.25e-01 -0.017300 9.37e-01
Apoptotic execution phase 43 8.45e-01 -0.017200 9.49e-01
Peptide hormone biosynthesis 11 9.22e-01 0.017000 9.69e-01
Ub-specific processing proteases 152 7.18e-01 0.017000 9.11e-01
AURKA Activation by TPX2 68 8.14e-01 0.016500 9.32e-01
Toll-like Receptor Cascades 157 7.24e-01 -0.016300 9.11e-01
Defective C1GALT1C1 causes TNPS 18 9.05e-01 0.016300 9.68e-01
RHOA GTPase cycle 140 7.42e-01 -0.016100 9.18e-01
Ion channel transport 173 7.15e-01 0.016100 9.11e-01
Synthesis of PA 35 8.70e-01 -0.016000 9.52e-01
Metallothioneins bind metals 11 9.27e-01 -0.016000 9.70e-01
Inwardly rectifying K+ channels 35 8.70e-01 -0.016000 9.52e-01
Mitotic Prometaphase 188 7.06e-01 0.016000 9.10e-01
Signaling by ERBB2 in Cancer 25 8.90e-01 -0.016000 9.62e-01
Free fatty acids regulate insulin secretion 10 9.31e-01 -0.015800 9.70e-01
E3 ubiquitin ligases ubiquitinate target proteins 42 8.61e-01 -0.015600 9.52e-01
Polo-like kinase mediated events 16 9.14e-01 0.015600 9.69e-01
Toll Like Receptor 4 (TLR4) Cascade 138 7.52e-01 -0.015600 9.20e-01
Cellular Senescence 130 7.63e-01 0.015300 9.25e-01
Infection with Mycobacterium tuberculosis 25 8.95e-01 0.015200 9.62e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 11 9.31e-01 -0.015100 9.70e-01
Metabolism of water-soluble vitamins and cofactors 121 7.75e-01 0.015000 9.27e-01
MET activates RAS signaling 11 9.31e-01 -0.015000 9.70e-01
Dopamine Neurotransmitter Release Cycle 20 9.08e-01 0.015000 9.69e-01
Fc epsilon receptor (FCERI) signaling 126 7.72e-01 0.014900 9.27e-01
Mitochondrial protein import 54 8.49e-01 -0.014900 9.51e-01
FCGR activation 12 9.29e-01 -0.014900 9.70e-01
Presynaptic nicotinic acetylcholine receptors 12 9.29e-01 -0.014800 9.70e-01
Signaling by CSF3 (G-CSF) 28 8.93e-01 0.014700 9.62e-01
Glycosaminoglycan metabolism 120 7.83e-01 0.014600 9.30e-01
Apoptosis 164 7.48e-01 0.014500 9.19e-01
Activation of AMPK downstream of NMDARs 28 8.95e-01 0.014400 9.62e-01
Diseases of programmed cell death 43 8.71e-01 -0.014400 9.52e-01
VEGFR2 mediated vascular permeability 26 8.99e-01 -0.014300 9.65e-01
Downstream signaling of activated FGFR3 24 9.04e-01 0.014200 9.68e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 9.36e-01 -0.013900 9.71e-01
ISG15 antiviral mechanism 71 8.40e-01 0.013900 9.45e-01
Activation of GABAB receptors 43 8.76e-01 -0.013700 9.55e-01
GABA B receptor activation 43 8.76e-01 -0.013700 9.55e-01
DNA Damage/Telomere Stress Induced Senescence 28 9.00e-01 0.013700 9.65e-01
PI-3K cascade:FGFR3 17 9.23e-01 -0.013600 9.69e-01
IRS-mediated signalling 47 8.74e-01 0.013300 9.54e-01
RAC3 GTPase cycle 84 8.34e-01 -0.013200 9.42e-01
Interleukin-4 and Interleukin-13 signaling 104 8.20e-01 -0.012900 9.36e-01
Transcription of E2F targets under negative control by DREAM complex 19 9.24e-01 0.012700 9.69e-01
Diseases associated with N-glycosylation of proteins 19 9.24e-01 -0.012700 9.69e-01
Signaling by NTRK2 (TRKB) 25 9.15e-01 -0.012400 9.69e-01
Nucleotide salvage 21 9.22e-01 -0.012400 9.69e-01
Cytochrome P450 - arranged by substrate type 64 8.65e-01 -0.012300 9.52e-01
HATs acetylate histones 71 8.60e-01 0.012100 9.52e-01
O-linked glycosylation 107 8.32e-01 0.011800 9.41e-01
EPHB-mediated forward signaling 41 8.98e-01 -0.011600 9.64e-01
HCMV Early Events 73 8.65e-01 -0.011500 9.52e-01
Maternal to zygotic transition (MZT) 76 8.65e-01 0.011300 9.52e-01
Metabolism of lipids 697 6.14e-01 0.011200 8.71e-01
Activation of SMO 17 9.36e-01 -0.011200 9.71e-01
L1CAM interactions 112 8.38e-01 0.011200 9.45e-01
Syndecan interactions 26 9.23e-01 0.010900 9.69e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 31 9.17e-01 0.010800 9.69e-01
Transcriptional regulation of granulopoiesis 31 9.17e-01 -0.010700 9.69e-01
Termination of O-glycan biosynthesis 25 9.26e-01 0.010700 9.70e-01
Apoptotic cleavage of cellular proteins 35 9.14e-01 -0.010500 9.69e-01
Class I MHC mediated antigen processing & presentation 361 7.31e-01 -0.010500 9.14e-01
Platelet Aggregation (Plug Formation) 39 9.10e-01 -0.010500 9.69e-01
Transmission across Chemical Synapses 255 7.74e-01 -0.010400 9.27e-01
Impaired BRCA2 binding to RAD51 33 9.17e-01 0.010400 9.69e-01
Programmed Cell Death 195 8.03e-01 -0.010300 9.30e-01
Cytoprotection by HMOX1 58 8.93e-01 0.010200 9.62e-01
tRNA processing 98 8.62e-01 -0.010100 9.52e-01
Cell-Cell communication 144 8.34e-01 -0.010100 9.42e-01
Pentose phosphate pathway 12 9.53e-01 0.009810 9.82e-01
TCR signaling 112 8.60e-01 -0.009630 9.52e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 619 6.90e-01 -0.009360 9.08e-01
CRMPs in Sema3A signaling 15 9.51e-01 -0.009200 9.81e-01
Glycosphingolipid catabolism 32 9.29e-01 -0.009150 9.70e-01
Gene Silencing by RNA 80 8.89e-01 0.009050 9.62e-01
Signaling by ERBB2 KD Mutants 24 9.39e-01 -0.009000 9.74e-01
Mitotic Prophase 78 8.92e-01 -0.008930 9.62e-01
G1/S-Specific Transcription 28 9.36e-01 -0.008830 9.71e-01
Nuclear Receptor transcription pathway 51 9.14e-01 -0.008700 9.69e-01
Kinesins 60 9.08e-01 -0.008640 9.69e-01
Neurotransmitter release cycle 47 9.19e-01 -0.008520 9.69e-01
Metabolism of steroid hormones 33 9.33e-01 0.008410 9.71e-01
Signaling by WNT in cancer 32 9.34e-01 0.008410 9.71e-01
COPI-independent Golgi-to-ER retrograde traffic 52 9.19e-01 0.008140 9.69e-01
Miscellaneous substrates 12 9.61e-01 0.008070 9.87e-01
Gap junction degradation 12 9.62e-01 0.007980 9.87e-01
CD28 dependent PI3K/Akt signaling 22 9.49e-01 -0.007920 9.80e-01
Ion homeostasis 52 9.22e-01 -0.007870 9.69e-01
Signal Transduction 2447 5.23e-01 -0.007840 8.23e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 11 9.64e-01 -0.007820 9.88e-01
Gap junction trafficking and regulation 49 9.25e-01 0.007780 9.69e-01
Signaling by ERBB2 TMD/JMD mutants 21 9.51e-01 -0.007710 9.81e-01
SARS-CoV-2 Infection 275 8.26e-01 0.007700 9.38e-01
Loss of Nlp from mitotic centrosomes 65 9.16e-01 -0.007600 9.69e-01
Loss of proteins required for interphase microtubule organization from the centrosome 65 9.16e-01 -0.007600 9.69e-01
MAPK family signaling cascades 313 8.24e-01 0.007320 9.37e-01
Cell-cell junction organization 82 9.09e-01 -0.007300 9.69e-01
Diseases of signal transduction by growth factor receptors and second messengers 412 7.99e-01 0.007290 9.30e-01
RAF/MAP kinase cascade 266 8.39e-01 0.007240 9.45e-01
Signaling by Rho GTPases 605 7.61e-01 -0.007240 9.23e-01
Cytokine Signaling in Immune system 728 7.39e-01 -0.007220 9.18e-01
Recruitment of NuMA to mitotic centrosomes 89 9.06e-01 -0.007220 9.69e-01
Synthesis of PC 27 9.50e-01 0.007020 9.81e-01
Intraflagellar transport 47 9.36e-01 0.006730 9.71e-01
RHOD GTPase cycle 48 9.36e-01 -0.006690 9.71e-01
Calcitonin-like ligand receptors 10 9.71e-01 0.006680 9.88e-01
Sema3A PAK dependent Axon repulsion 14 9.66e-01 -0.006580 9.88e-01
Removal of the Flap Intermediate from the C-strand 17 9.63e-01 -0.006540 9.88e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 101 9.10e-01 0.006510 9.69e-01
Carboxyterminal post-translational modifications of tubulin 44 9.41e-01 -0.006430 9.75e-01
RUNX3 regulates p14-ARF 10 9.72e-01 -0.006310 9.88e-01
PRC2 methylates histones and DNA 13 9.70e-01 -0.006060 9.88e-01
MAPK1/MAPK3 signaling 272 8.66e-01 0.005950 9.52e-01
PI3K Cascade 43 9.47e-01 0.005890 9.79e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 14 9.70e-01 0.005710 9.88e-01
Dissolution of Fibrin Clot 13 9.72e-01 0.005590 9.88e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 199 8.94e-01 -0.005470 9.62e-01
Glucocorticoid biosynthesis 10 9.76e-01 -0.005440 9.89e-01
MHC class II antigen presentation 122 9.19e-01 0.005340 9.69e-01
FRS-mediated FGFR3 signaling 19 9.68e-01 -0.005260 9.88e-01
RND3 GTPase cycle 41 9.56e-01 0.005020 9.84e-01
Base-Excision Repair, AP Site Formation 18 9.71e-01 0.004990 9.88e-01
Processive synthesis on the C-strand of the telomere 19 9.70e-01 -0.004990 9.88e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 45 9.58e-01 -0.004530 9.85e-01
Activation of NMDA receptors and postsynaptic events 87 9.43e-01 -0.004430 9.76e-01
RET signaling 41 9.63e-01 -0.004150 9.88e-01
RA biosynthesis pathway 22 9.74e-01 0.003980 9.89e-01
MET promotes cell motility 41 9.66e-01 -0.003850 9.88e-01
Gap junction assembly 36 9.68e-01 0.003820 9.88e-01
Pre-NOTCH Processing in Golgi 18 9.78e-01 -0.003780 9.90e-01
Organelle biogenesis and maintenance 254 9.19e-01 -0.003680 9.69e-01
Antigen processing: Ubiquitination & Proteasome degradation 293 9.18e-01 0.003490 9.69e-01
Cleavage of the damaged pyrimidine 16 9.82e-01 0.003250 9.91e-01
Depyrimidination 16 9.82e-01 0.003250 9.91e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 16 9.82e-01 0.003250 9.91e-01
Protein ubiquitination 60 9.66e-01 0.003150 9.88e-01
RHO GTPases activate IQGAPs 31 9.76e-01 0.003070 9.89e-01
Polymerase switching on the C-strand of the telomere 24 9.79e-01 -0.003040 9.90e-01
HCMV Infection 97 9.61e-01 0.002890 9.87e-01
Post NMDA receptor activation events 76 9.68e-01 -0.002700 9.88e-01
Lewis blood group biosynthesis 18 9.86e-01 -0.002450 9.92e-01
Interferon Signaling 256 9.47e-01 0.002420 9.79e-01
Deubiquitination 225 9.52e-01 -0.002310 9.81e-01
Interleukin-12 signaling 43 9.80e-01 -0.002240 9.90e-01
Role of phospholipids in phagocytosis 23 9.86e-01 -0.002180 9.92e-01
E2F mediated regulation of DNA replication 20 9.87e-01 0.002150 9.92e-01
Zygotic genome activation (ZGA) 15 9.90e-01 -0.001800 9.94e-01
Apoptotic cleavage of cell adhesion proteins 11 9.92e-01 -0.001740 9.94e-01
Telomere C-strand (Lagging Strand) Synthesis 32 9.87e-01 0.001690 9.92e-01
Degradation of the extracellular matrix 135 9.74e-01 -0.001650 9.88e-01
MET activates PTK2 signaling 30 9.88e-01 -0.001590 9.93e-01
CaMK IV-mediated phosphorylation of CREB 10 9.94e-01 0.001340 9.94e-01
Fatty acyl-CoA biosynthesis 36 9.90e-01 -0.001180 9.94e-01
Negative regulation of MET activity 20 9.93e-01 -0.001070 9.94e-01
Biological oxidations 213 9.79e-01 0.001050 9.90e-01
Platelet calcium homeostasis 27 9.94e-01 -0.000833 9.94e-01
Gap junction trafficking 47 9.94e-01 0.000658 9.94e-01
Assembly of collagen fibrils and other multimeric structures 59 9.93e-01 0.000635 9.94e-01
Signaling by Interleukins 434 9.84e-01 0.000548 9.92e-01


Detailed Gene set reports



Chylomicron remodeling

Chylomicron remodeling
210
set Chylomicron remodeling
setSize 10
pANOVA 0.00254
s.dist 0.551
p.adjustANOVA 0.0482



Top enriched genes

Top 20 genes
GeneID Gene Rank
APOA2 17615
LPL 17101
APOC3 15561
APOC2 14895
APOA5 14684
APOA1 12062
GPIHBP1 10408
APOA4 10060
APOE 9123
APOB 3390

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOA2 17615
LPL 17101
APOC3 15561
APOC2 14895
APOA5 14684
APOA1 12062
GPIHBP1 10408
APOA4 10060
APOE 9123
APOB 3390


TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
1419
set TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
setSize 11
pANOVA 0.00165
s.dist 0.548
p.adjustANOVA 0.0359



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
IRF7 15832
UBA52 15146
UBB 15063
UBE2V1 14282
MYD88 10379
TRAF6 9524
IRAK4 9466
TLR9 8295
UBE2N 4251

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
IRF7 15832
UBA52 15146
UBB 15063
UBE2V1 14282
MYD88 10379
TRAF6 9524
IRAK4 9466
TLR9 8295
UBE2N 4251


SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery
1194
set SARS-CoV-1 modulates host translation machinery
setSize 34
pANOVA 1.73e-07
s.dist 0.518
p.adjustANOVA 9.79e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPS27A 17623
RPS14 17460
RPSA 16750
RPS27 16701
RPS28 16547
RPS16 16394
RPS10 16101
HNRNPA1 16020
RPS21 15733
RPS24 15434
RPS11 15381
RPS26 15184
RPS23 15084
RPS25 14869
RPS6 14761
RPS9 14415
RPS29 14234
RPS2 12789
RPS7 12370

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998
RPS27A 17623
RPS14 17460
RPSA 16750
RPS27 16701
RPS28 16547
RPS16 16394
RPS10 16101
HNRNPA1 16020
RPS21 15733
RPS24 15434
RPS11 15381
RPS26 15184
RPS23 15084
RPS25 14869
RPS6 14761
RPS9 14415
RPS29 14234
RPS2 12789
RPS7 12370
RPS5 11632
RPS18 11410
RPS3A 11123
RPS19 10890
RPS8 10296
RPS27L 9869
EEF1A1 9096
RPS13 7369
RPS20 7077
RPS3 5505
RPS15A 3120
RPS12 2257
RPS15 -220
FAU -1469


Josephin domain DUBs

Josephin domain DUBs
669
set Josephin domain DUBs
setSize 11
pANOVA 0.00549
s.dist 0.483
p.adjustANOVA 0.0805



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 17623
JOSD2 17047
UBC 17042
RAD23A 15562
UBA52 15146
UBB 15063
JOSD1 12720
VCP 11557
RAD23B 4991
ATXN3 3743
PARK2 -2692

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 17623
JOSD2 17047
UBC 17042
RAD23A 15562
UBA52 15146
UBB 15063
JOSD1 12720
VCP 11557
RAD23B 4991
ATXN3 3743
PARK2 -2692


TRAF6 mediated IRF7 activation

TRAF6 mediated IRF7 activation
1418
set TRAF6 mediated IRF7 activation
setSize 25
pANOVA 5.09e-05
s.dist -0.468
p.adjustANOVA 0.00172



Top enriched genes

Top 20 genes
GeneID Gene Rank
IFNA6 -7454
IFNA16 -7423
IFNA2 -7251
IFNA21 -7180
IFNA14 -7099
IFNB1 -7088
IFNA1 -7038
TRIM4 -6652
IFNA5 -5828
TANK -5660
IFNA7 -4450
SIKE1 -4057
IFNA8 -2780
TBK1 -2417
TRIM25 -1856
EP300 381
CREBBP 955
IRF3 3496
RNF135 4528
IFIH1 5240

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFNA6 -7454
IFNA16 -7423
IFNA2 -7251
IFNA21 -7180
IFNA14 -7099
IFNB1 -7088
IFNA1 -7038
TRIM4 -6652
IFNA5 -5828
TANK -5660
IFNA7 -4450
SIKE1 -4057
IFNA8 -2780
TBK1 -2417
TRIM25 -1856
EP300 381
CREBBP 955
IRF3 3496
RNF135 4528
IFIH1 5240
MAVS 5384
TRAF2 8353
TRAF6 9524
IKBKE 15091
IRF7 15832


Class C/3 (Metabotropic glutamate/pheromone receptors)

Class C/3 (Metabotropic glutamate/pheromone receptors)
216
set Class C/3 (Metabotropic glutamate/pheromone receptors)
setSize 39
pANOVA 6.08e-07
s.dist -0.461
p.adjustANOVA 3.33e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAS2R46 -7339
TAS2R10 -7306
TAS2R4 -7233
TAS2R14 -6983
TAS2R50 -6656
TAS2R8 -6601
TAS2R43 -6600
TAS2R39 -6469
TAS2R13 -6411
TAS2R3 -6389
TAS2R60 -5931
TAS2R31 -5781
TAS2R30 -5769
TAS2R5 -5318
TAS2R42 -5043
GRM5 -4895
TAS2R19 -4787
TAS2R7 -4436
TAS2R16 -4099
TAS2R1 -3267

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAS2R46 -7339
TAS2R10 -7306
TAS2R4 -7233
TAS2R14 -6983
TAS2R50 -6656
TAS2R8 -6601
TAS2R43 -6600
TAS2R39 -6469
TAS2R13 -6411
TAS2R3 -6389
TAS2R60 -5931
TAS2R31 -5781
TAS2R30 -5769
TAS2R5 -5318
TAS2R42 -5043
GRM5 -4895
TAS2R19 -4787
TAS2R7 -4436
TAS2R16 -4099
TAS2R1 -3267
TAS2R38 -2766
TAS1R2 -767
TAS2R20 -749
TAS2R9 481
GRM7 954
CASR 1209
GRM8 1491
GRM1 2427
GABBR1 5279
TAS1R3 5729
GRM2 5849
GABBR2 6454
TAS2R40 7295
GRM6 7787
GRM4 8862
GPRC6A 9013
TAS2R41 9019
GRM3 12208
TAS1R1 16838


SUMOylation of immune response proteins

SUMOylation of immune response proteins
1229
set SUMOylation of immune response proteins
setSize 11
pANOVA 0.00867
s.dist 0.457
p.adjustANOVA 0.112



Top enriched genes

Top 20 genes
GeneID Gene Rank
PIAS3 16789
SUMO1 15514
NFKBIA 15415
IKBKE 15091
NFKB2 13895
RELA 12906
TOPORS 11451
UBE2I 10454
PIAS4 9746
SUMO3 3785
EIF2AK2 -993

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIAS3 16789
SUMO1 15514
NFKBIA 15415
IKBKE 15091
NFKB2 13895
RELA 12906
TOPORS 11451
UBE2I 10454
PIAS4 9746
SUMO3 3785
EIF2AK2 -993


Pexophagy

Pexophagy
934
set Pexophagy
setSize 11
pANOVA 0.00889
s.dist 0.455
p.adjustANOVA 0.114



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
PEX5 17036
MAP1LC3B 15762
UBA52 15146
UBB 15063
NBR1 14839
ATM 10689
SQSTM1 5152
EPAS1 -2163
USP30 -2346

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
PEX5 17036
MAP1LC3B 15762
UBA52 15146
UBB 15063
NBR1 14839
ATM 10689
SQSTM1 5152
EPAS1 -2163
USP30 -2346


Phase 4 - resting membrane potential

Phase 4 - resting membrane potential
937
set Phase 4 - resting membrane potential
setSize 19
pANOVA 0.0011
s.dist 0.432
p.adjustANOVA 0.0277



Top enriched genes

Top 20 genes
GeneID Gene Rank
KCNK16 17421
KCNJ4 16930
KCNK18 16819
KCNJ12 16370
KCNK15 15074
KCNK6 14501
KCNK7 13732
KCNJ14 12733
KCNK17 12557
KCNK10 11671
KCNK4 10547
KCNK12 9301
KCNK3 9192
KCNK5 8778
KCNK9 8381
KCNJ2 7972
KCNK1 4007
KCNK13 1366
KCNK2 866

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KCNK16 17421
KCNJ4 16930
KCNK18 16819
KCNJ12 16370
KCNK15 15074
KCNK6 14501
KCNK7 13732
KCNJ14 12733
KCNK17 12557
KCNK10 11671
KCNK4 10547
KCNK12 9301
KCNK3 9192
KCNK5 8778
KCNK9 8381
KCNJ2 7972
KCNK1 4007
KCNK13 1366
KCNK2 866


Interaction With Cumulus Cells And The Zona Pellucida

Interaction With Cumulus Cells And The Zona Pellucida
630
set Interaction With Cumulus Cells And The Zona Pellucida
setSize 11
pANOVA 0.0143
s.dist -0.426
p.adjustANOVA 0.155



Top enriched genes

Top 20 genes
GeneID Gene Rank
ADAM20 -6401
SPAM1 -6352
ADAM2 -4855
ADAM21 -4386
B4GALT1 -1620
ZP4 -1539
OVGP1 -444
ZP2 2669
ADAM30 3126
ZP3 7641
ZP1 11219

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ADAM20 -6401
SPAM1 -6352
ADAM2 -4855
ADAM21 -4386
B4GALT1 -1620
ZP4 -1539
OVGP1 -444
ZP2 2669
ADAM30 3126
ZP3 7641
ZP1 11219


Regulation of CDH11 gene transcription

Regulation of CDH11 gene transcription
1109
set Regulation of CDH11 gene transcription
setSize 10
pANOVA 0.0208
s.dist 0.422
p.adjustANOVA 0.19



Top enriched genes

Top 20 genes
GeneID Gene Rank
HOXC8 17775
SP1 16404
BHLHE22 16156
PRDM8 15535
FOXF1 14246
HEYL 13939
ILF3 7799
SNAI1 4808
ZEB2 3623
CDH11 -1980

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HOXC8 17775
SP1 16404
BHLHE22 16156
PRDM8 15535
FOXF1 14246
HEYL 13939
ILF3 7799
SNAI1 4808
ZEB2 3623
CDH11 -1980


Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors
403
set Expression and translocation of olfactory receptors
setSize 358
pANOVA 3.01e-42
s.dist -0.418
p.adjustANOVA 4.77e-39



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR2A12 -7381
OR7E24 -7370
OR8U1 -7368
OR52A5 -7357
OR52D1 -7353
OR4Q3 -7352
OR13C8 -7292
OR10H3 -7285
OR52E4 -7279
OR5K1 -7254
OR8B2 -7245
OR4N4 -7225
OR8H1 -7216
OR6C1 -7212
OR2G6 -7211
OR5AC2 -7206
OR51G2 -7199
OR5T2 -7182
OR4D5 -7160
OR2W3 -7151

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR2A12 -7381.0
OR7E24 -7370.0
OR8U1 -7368.0
OR52A5 -7357.0
OR52D1 -7353.0
OR4Q3 -7352.0
OR13C8 -7292.0
OR10H3 -7285.0
OR52E4 -7279.0
OR5K1 -7254.0
OR8B2 -7245.0
OR4N4 -7225.0
OR8H1 -7216.0
OR6C1 -7212.0
OR2G6 -7211.0
OR5AC2 -7206.0
OR51G2 -7199.0
OR5T2 -7182.0
OR4D5 -7160.0
OR2W3 -7151.0
OR1J2 -7147.0
OR2G3 -7137.0
OR8D1 -7128.0
OR5K2 -7124.0
OR5P2 -7115.0
OR5K4 -7106.0
OR2T33 -7059.0
OR5B12 -7058.0
OR4F15 -7048.0
OR4E2 -7013.0
OR2B6 -7012.0
OR6Q1 -7011.0
OR7G2 -6985.0
OR52H1 -6976.0
OR6M1 -6975.0
OR11G2 -6970.0
OR13F1 -6959.0
OR10G9 -6944.0
OR52I2 -6940.0
OR8I2 -6922.0
OR51I1 -6895.0
OR2K2 -6891.0
OR7D4 -6884.0
OR5K3 -6882.0
OR5AP2 -6877.0
OR6C2 -6858.0
OR9G1 -6835.5
OR9G9 -6835.5
OR4C45 -6834.0
OR5D18 -6810.0
OR13C4 -6790.0
OR14A16 -6781.0
OR12D2 -6765.0
OR51B6 -6753.0
OR5F1 -6736.0
OR2B3 -6721.0
OR8D2 -6714.0
OR52I1 -6682.0
OR10K2 -6671.0
OR5AK2 -6666.0
OR1S1 -6615.0
OR13C2 -6588.0
OR6K6 -6556.0
OR2A2 -6552.0
OR5AN1 -6525.0
OR10J1 -6509.0
OR4K14 -6507.0
OR6C75 -6488.0
OR10J5 -6486.0
OR10G8 -6474.0
OR56A1 -6409.0
OR8K3 -6403.0
OR13G1 -6377.0
OR1Q1 -6372.0
OR2T10 -6350.0
OR2M5 -6345.0
OR13C3 -6339.0
OR5P3 -6333.0
OR10W1 -6317.0
OR4N5 -6306.0
OR5AS1 -6278.0
OR5H1 -6252.0
OR10G4 -6218.0
OR6C6 -6213.0
OR6N2 -6200.0
OR10Q1 -6180.0
OR8U8 -6153.0
OR51V1 -6140.0
OR8H2 -6098.0
OR5M9 -6090.0
OR6C3 -6089.0
OR4B1 -6088.0
OR1J1 -6071.0
OR5D14 -6062.0
OR5L2 -6055.0
OR4C46 -5996.0
OR6B1 -5960.0
OR2A14 -5920.0
OR52E6 -5900.0
OR4D10 -5889.0
OR11A1 -5871.0
OR6C74 -5838.0
OR6C4 -5836.0
OR5W2 -5825.0
OR2W1 -5811.0
OR8H3 -5790.0
OR3A2 -5776.0
OR7A10 -5772.0
OR2M4 -5748.0
OR5M11 -5726.0
OR51I2 -5649.0
OR51A7 -5647.0
OR5M10 -5630.0
OR5H2 -5605.0
OR9G4 -5594.0
OR5D16 -5563.0
OR2D3 -5546.0
OR1K1 -5497.0
OR6F1 -5459.0
OR1L3 -5413.0
OR11H4 -5359.0
OR4A16 -5356.0
OR52N2 -5327.0
OR51B5 -5325.0
OR5B3 -5286.0
OR2AK2 -5177.0
OR4P4 -5158.0
OR4M1 -5143.0
OR8J3 -5140.0
OR10A6 -5124.0
OR8J1 -5121.0
OR1A2 -5098.0
OR4C13 -5097.0
OR2T1 -5034.0
OR2J2 -5002.0
OR1A1 -4982.0
OR1N2 -4924.0
OR4K13 -4922.0
OR4D1 -4911.0
OR8A1 -4865.0
OR52M1 -4652.0
OR2T8 -4611.0
OR10A4 -4558.0
OR10AD1 -4545.0
OR52E8 -4542.0
OR4A47 -4495.0
OR6B3 -4493.0
OR5M8 -4482.0
OR1E1 -4435.0
OR6A2 -4158.0
OR2Y1 -4123.0
OR5M3 -4106.0
OR52A1 -4101.0
OR52B6 -4041.0
OR9A2 -4028.0
OR5T3 -3979.0
OR5M1 -3966.0
OR7G1 -3955.0
OR4C12 -3940.0
OR6C70 -3937.0
OR10A7 -3934.0
OR2T34 -3916.0
OR6C76 -3912.0
OR6T1 -3825.0
OR8S1 -3730.0
OR2L8 -3715.0
OR2H1 -3700.0
OR2AG1 -3691.0
OR3A1 -3664.0
OR5H6 -3651.0
OR10G3 -3640.0
OR52K2 -3629.0
OR1I1 -3613.0
OR4C6 -3499.0
OR51L1 -3475.0
OR10G7 -3459.0
OR51E2 -3430.0
OR4K17 -3422.0
OR2L5 -3421.0
OR2B2 -3311.0
OR10G2 -3176.0
OR8K1 -3167.0
OR51A2 -3135.0
OR8G1 -3112.0
OR10H1 -3075.0
OR51F2 -3040.0
OR2L13 -2985.0
OR2T6 -2956.0
OR52N1 -2928.0
OR4D11 -2894.0
OR4N2 -2891.0
OR10AG1 -2553.0
OR52R1 -2519.0
OR1B1 -2477.0
OR2J3 -2412.0
OR5V1 -2284.0
OR51T1 -2207.0
OR51B4 -2171.0
OR4K1 -2153.0
OR14C36 -2066.0
OR4D9 -1979.0
OR2G2 -1911.0
OR51B2 -1813.0
OR4X2 -1674.0
OR5B2 -1670.0
OR2M3 -1627.0
OR10S1 -1558.0
OR2T3 -1489.0
OR5H15 -1427.0
OR6P1 -1408.0
OR7A5 -1357.0
OR4F6 -1282.0
OR5C1 -1268.0
OR10A3 -1203.0
OR9Q1 -1199.0
OR6C65 -1188.0
OR1J4 -1182.0
OR2T4 -1063.0
OR56A3 -1024.0
OR2F1 -957.0
OR5T1 -950.0
OR6S1 -839.0
OR5R1 -770.0
OR6X1 -670.0
OR7C1 -596.0
OR1C1 -469.0
OR10H4 -416.0
OR7D2 -245.0
OR10C1 189.0
REEP1 222.0
OR51D1 350.0
OR4D6 393.0
OR14I1 439.0
OR52E2 529.0
OR5AU1 826.0
OR1L6 884.0
OR5A1 981.0
OR56A4 1233.0
OR12D3 1425.0
OR52N5 1434.0
OR4K15 1581.0
OR1M1 1617.0
OR5I1 1930.0
OR52K1 2152.0
OR7A17 2227.0
OR52J3 2294.0
OR8B12 2362.0
OR4S2 2386.0
OR6Y1 2477.0
OR4K2 2788.0
OR9K2 2795.0
OR2L3 2808.0
OR7C2 2904.0
OR14J1 2966.0
OR10T2 3085.0
OR2C1 3091.0
OR6V1 3199.0
OR4D2 3275.0
OR13C9 3403.0
OR1E2 3635.0
OR11L1 3856.0
OR2AG2 3965.0
OR11H6 3984.0
OR8D4 4764.0
OR1L8 4766.0
OR4L1 4792.0
OR8G5 4800.0
OR6B2 5006.0
EBF1 5132.0
OR2A25 5362.0
OR5D13 5440.0
OR5B17 5595.0
OR4C3 5647.0
OR56A5 5830.0
OR13J1 5895.0
OR2Z1 6091.0
OR9Q2 6260.0
OR9I1 6545.0
OR4K5 6553.0
OR2M7 6606.0
OR51M1 6711.0
OR6K2 6910.0
OR2D2 6931.0
OR2AT4 7019.0
RTP1 7037.0
OR2H2 7205.0
OR4M2 7432.0
OR51S1 7615.0
OR2T27 7636.0
OR4C15 7930.0
OR10A5 8093.0
OR51E1 8132.0
OR2T11 8306.0
OR1L4 8788.0
OR2W5 8872.0
OR10K1 8931.0
OR1D2 9324.0
OR10X1 9650.0
OR4X1 10189.0
OR8K5 10313.0
OR1N1 10825.0
OR2S2 10832.0
OR10A2 10874.0
OR52L1 11054.0
OR1L1 11223.0
OR2V2 11274.0
OR2F2 11301.0
OR1F1 11439.0
OR5J2 11629.0
OR2AE1 11641.0
OR5A2 12082.0
LHX2 12100.0
OR11H2 12259.0
OR9A4 12413.0
OR51G1 12446.0
OR1G1 12459.0
OR4S1 12547.0
OR3A3 12685.0
LDB1 12794.0
OR8B4 12984.0
OR10H5 13076.0
OR4A15 13189.0
OR13A1 13331.0
OR10Z1 13351.0
OR2B11 13393.0
OR52W1 13423.0
OR5B21 13461.0
OR10J3 13598.0
OR2C3 13675.0
OR6N1 13782.0
OR4A5 14912.0
OR4C16 14952.0
OR10P1 15124.0
OR2L2 15471.0
OR1S2 15520.0
OR5L1 15697.0
OR51A4 15799.0
OR6K3 15979.0
OR5AR1 16000.0
OR56B1 16282.0
OR2V1 16351.0
OR10R2 16396.0
OR52B2 16410.0
OR2M2 16490.0
OR10H2 16512.0
OR10V1 16587.0
OR51F1 16686.0
OR8B8 16831.0
OR51Q1 16994.0
OR2AP1 17117.0
RTP2 17287.0
OR6C68 17620.0
OR56B4 17811.0
OR2A5 17820.0
OR8G2 18086.0
OR13D1 18192.0
OR4C11 18210.0
OR7G3 18227.0


NF-kB is activated and signals survival

NF-kB is activated and signals survival
798
set NF-kB is activated and signals survival
setSize 12
pANOVA 0.0125
s.dist 0.416
p.adjustANOVA 0.143



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
NFKBIA 15415
UBA52 15146
UBB 15063
RELA 12906
TRAF6 9524
NGF 8768
NGFR 7653
IKBKB 7359
SQSTM1 5152
NFKB1 -2596

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
NFKBIA 15415
UBA52 15146
UBB 15063
RELA 12906
TRAF6 9524
NGF 8768
NGFR 7653
IKBKB 7359
SQSTM1 5152
NFKB1 -2596


Peptide chain elongation

Peptide chain elongation
927
set Peptide chain elongation
setSize 84
pANOVA 6.63e-11
s.dist 0.412
p.adjustANOVA 1.31e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPL35A 17964
RPS27A 17623
RPL34 17570
RPS14 17460
RPL27 17419
RPL18A 17406
RPSA 16750
RPS27 16701
RPS28 16547
RPL32 16401
RPS16 16394
RPL28 16373
RPS10 16101
EEF2 15877
RPL7 15788
RPS21 15733
RPL29 15716
RPL10L 15577
RPL17 15487

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPL35A 17964.0
RPS27A 17623.0
RPL34 17570.0
RPS14 17460.0
RPL27 17419.0
RPL18A 17406.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPL32 16401.0
RPS16 16394.0
RPL28 16373.0
RPS10 16101.0
EEF2 15877.0
RPL7 15788.0
RPS21 15733.0
RPL29 15716.0
RPL10L 15577.0
RPL17 15487.0
RPS24 15434.0
RPL23 15404.0
RPS11 15381.0
RPL38 15324.0
RPS26 15184.0
UBA52 15146.0
RPS23 15084.0
RPL24 14927.0
RPS25 14869.0
RPS6 14761.0
RPL9 14519.0
RPS9 14415.0
RPS29 14234.0
RPL26L1 14132.0
RPL30 13945.0
RPL14 13883.0
RPL26 13496.0
RPL7A 13425.0
RPS2 12789.0
RPL12 12744.0
RPL41 12555.0
RPS7 12370.0
RPL37A 11838.0
RPL3L 11730.0
RPS5 11632.0
RPS18 11410.0
RPL13A 11201.5
RPS3A 11123.0
RPL19 10992.0
RPS19 10890.0
RPL13 10808.0
RPS8 10296.0
RPS27L 9869.0
RPL39L 9655.0
RPL18 9621.0
EEF1A1 9096.0
RPL23A 8852.0
RPLP1 8689.0
RPLP2 8239.0
RPL37 7695.0
RPS13 7369.0
RPL36AL 7147.0
RPS20 7077.0
RPL4 6779.0
RPL36 6145.0
RPS3 5505.0
RPL8 5310.0
RPL10A 5072.0
RPL15 4446.0
RPL3 4267.0
RPLP0 3455.0
RPS15A 3120.0
RPL11 2419.0
RPS12 2257.0
RPL27A 1306.0
RPL22 1272.0
RPL5 852.0
RPL31 733.0
RPL35 467.0
RPS15 -220.0
RPL21 -682.0
FAU -1469.0
RPL22L1 -1702.0
RPL6 -4235.0


Regulation of NF-kappa B signaling

Regulation of NF-kappa B signaling
1122
set Regulation of NF-kappa B signaling
setSize 17
pANOVA 0.00341
s.dist 0.41
p.adjustANOVA 0.0589



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
UBA52 15146
LRRC14 15139
UBB 15063
USP18 14882
IKBIP 12610
NLRX1 12126
TP53 11464
NLRC5 9936
TRAF6 9524
USP14 8938
TRAF2 8353
IKBKB 7359
CASP8 7096
N4BP1 1599
CHUK -2452

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
UBA52 15146
LRRC14 15139
UBB 15063
USP18 14882
IKBIP 12610
NLRX1 12126
TP53 11464
NLRC5 9936
TRAF6 9524
USP14 8938
TRAF2 8353
IKBKB 7359
CASP8 7096
N4BP1 1599
CHUK -2452


Olfactory Signaling Pathway

Olfactory Signaling Pathway
875
set Olfactory Signaling Pathway
setSize 365
pANOVA 3.28e-41
s.dist -0.409
p.adjustANOVA 2.6e-38



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR2A12 -7381
OR7E24 -7370
OR8U1 -7368
OR52A5 -7357
OR52D1 -7353
OR4Q3 -7352
OR13C8 -7292
OR10H3 -7285
OR52E4 -7279
OR5K1 -7254
OR8B2 -7245
OR4N4 -7225
OR8H1 -7216
OR6C1 -7212
OR2G6 -7211
OR5AC2 -7206
OR51G2 -7199
OR5T2 -7182
OR4D5 -7160
OR2W3 -7151

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR2A12 -7381.0
OR7E24 -7370.0
OR8U1 -7368.0
OR52A5 -7357.0
OR52D1 -7353.0
OR4Q3 -7352.0
OR13C8 -7292.0
OR10H3 -7285.0
OR52E4 -7279.0
OR5K1 -7254.0
OR8B2 -7245.0
OR4N4 -7225.0
OR8H1 -7216.0
OR6C1 -7212.0
OR2G6 -7211.0
OR5AC2 -7206.0
OR51G2 -7199.0
OR5T2 -7182.0
OR4D5 -7160.0
OR2W3 -7151.0
OR1J2 -7147.0
OR2G3 -7137.0
OR8D1 -7128.0
OR5K2 -7124.0
OR5P2 -7115.0
OR5K4 -7106.0
OR2T33 -7059.0
OR5B12 -7058.0
OR4F15 -7048.0
OR4E2 -7013.0
OR2B6 -7012.0
OR6Q1 -7011.0
OR7G2 -6985.0
OR52H1 -6976.0
OR6M1 -6975.0
OR11G2 -6970.0
OR13F1 -6959.0
OR10G9 -6944.0
OR52I2 -6940.0
OR8I2 -6922.0
OR51I1 -6895.0
OR2K2 -6891.0
OR7D4 -6884.0
OR5K3 -6882.0
OR5AP2 -6877.0
OR6C2 -6858.0
OR9G1 -6835.5
OR9G9 -6835.5
OR4C45 -6834.0
OR5D18 -6810.0
OR13C4 -6790.0
OR14A16 -6781.0
OR12D2 -6765.0
OR51B6 -6753.0
OR5F1 -6736.0
OR2B3 -6721.0
OR8D2 -6714.0
OR52I1 -6682.0
OR10K2 -6671.0
OR5AK2 -6666.0
OR1S1 -6615.0
OR13C2 -6588.0
OR6K6 -6556.0
OR2A2 -6552.0
OR5AN1 -6525.0
OR10J1 -6509.0
OR4K14 -6507.0
OR6C75 -6488.0
OR10J5 -6486.0
OR10G8 -6474.0
OR56A1 -6409.0
OR8K3 -6403.0
OR13G1 -6377.0
OR1Q1 -6372.0
OR2T10 -6350.0
OR2M5 -6345.0
OR13C3 -6339.0
OR5P3 -6333.0
OR10W1 -6317.0
OR4N5 -6306.0
OR5AS1 -6278.0
OR5H1 -6252.0
OR10G4 -6218.0
OR6C6 -6213.0
OR6N2 -6200.0
OR10Q1 -6180.0
OR8U8 -6153.0
OR51V1 -6140.0
OR8H2 -6098.0
OR5M9 -6090.0
OR6C3 -6089.0
OR4B1 -6088.0
OR1J1 -6071.0
OR5D14 -6062.0
OR5L2 -6055.0
OR4C46 -5996.0
OR6B1 -5960.0
OR2A14 -5920.0
OR52E6 -5900.0
OR4D10 -5889.0
OR11A1 -5871.0
OR6C74 -5838.0
OR6C4 -5836.0
OR5W2 -5825.0
OR2W1 -5811.0
OR8H3 -5790.0
OR3A2 -5776.0
OR7A10 -5772.0
OR2M4 -5748.0
OR5M11 -5726.0
OR51I2 -5649.0
OR51A7 -5647.0
OR5M10 -5630.0
OR5H2 -5605.0
OR9G4 -5594.0
OR5D16 -5563.0
OR2D3 -5546.0
OR1K1 -5497.0
OR6F1 -5459.0
OR1L3 -5413.0
OR11H4 -5359.0
OR4A16 -5356.0
OR52N2 -5327.0
OR51B5 -5325.0
OR5B3 -5286.0
OR2AK2 -5177.0
OR4P4 -5158.0
OR4M1 -5143.0
OR8J3 -5140.0
OR10A6 -5124.0
OR8J1 -5121.0
OR1A2 -5098.0
OR4C13 -5097.0
OR2T1 -5034.0
OR2J2 -5002.0
OR1A1 -4982.0
OR1N2 -4924.0
OR4K13 -4922.0
OR4D1 -4911.0
OR8A1 -4865.0
OR52M1 -4652.0
OR2T8 -4611.0
OR10A4 -4558.0
OR10AD1 -4545.0
OR52E8 -4542.0
OR4A47 -4495.0
OR6B3 -4493.0
OR5M8 -4482.0
OR1E1 -4435.0
OR6A2 -4158.0
OR2Y1 -4123.0
OR5M3 -4106.0
OR52A1 -4101.0
GNG13 -4054.0
OR52B6 -4041.0
OR9A2 -4028.0
OR5T3 -3979.0
OR5M1 -3966.0
OR7G1 -3955.0
OR4C12 -3940.0
OR6C70 -3937.0
OR10A7 -3934.0
OR2T34 -3916.0
OR6C76 -3912.0
OR6T1 -3825.0
OR8S1 -3730.0
OR2L8 -3715.0
OR2H1 -3700.0
OR2AG1 -3691.0
OR3A1 -3664.0
OR5H6 -3651.0
OR10G3 -3640.0
OR52K2 -3629.0
OR1I1 -3613.0
OR4C6 -3499.0
OR51L1 -3475.0
OR10G7 -3459.0
OR51E2 -3430.0
OR4K17 -3422.0
OR2L5 -3421.0
OR2B2 -3311.0
OR10G2 -3176.0
OR8K1 -3167.0
OR51A2 -3135.0
OR8G1 -3112.0
OR10H1 -3075.0
OR51F2 -3040.0
OR2L13 -2985.0
OR2T6 -2956.0
OR52N1 -2928.0
OR4D11 -2894.0
OR4N2 -2891.0
OR10AG1 -2553.0
OR52R1 -2519.0
OR1B1 -2477.0
OR2J3 -2412.0
OR5V1 -2284.0
OR51T1 -2207.0
OR51B4 -2171.0
OR4K1 -2153.0
OR14C36 -2066.0
OR4D9 -1979.0
OR2G2 -1911.0
OR51B2 -1813.0
OR4X2 -1674.0
OR5B2 -1670.0
OR2M3 -1627.0
OR10S1 -1558.0
OR2T3 -1489.0
OR5H15 -1427.0
OR6P1 -1408.0
OR7A5 -1357.0
OR4F6 -1282.0
OR5C1 -1268.0
OR10A3 -1203.0
OR9Q1 -1199.0
OR6C65 -1188.0
OR1J4 -1182.0
OR2T4 -1063.0
OR56A3 -1024.0
OR2F1 -957.0
OR5T1 -950.0
OR6S1 -839.0
OR5R1 -770.0
OR6X1 -670.0
OR7C1 -596.0
OR1C1 -469.0
OR10H4 -416.0
OR7D2 -245.0
OR10C1 189.0
REEP1 222.0
OR51D1 350.0
OR4D6 393.0
OR14I1 439.0
OR52E2 529.0
OR5AU1 826.0
OR1L6 884.0
OR5A1 981.0
OR56A4 1233.0
OR12D3 1425.0
OR52N5 1434.0
OR4K15 1581.0
OR1M1 1617.0
OR5I1 1930.0
ANO2 2111.0
OR52K1 2152.0
OR7A17 2227.0
OR52J3 2294.0
OR8B12 2362.0
OR4S2 2386.0
OR6Y1 2477.0
GNB1 2634.0
OR4K2 2788.0
OR9K2 2795.0
OR2L3 2808.0
OR7C2 2904.0
OR14J1 2966.0
OR10T2 3085.0
OR2C1 3091.0
OR6V1 3199.0
OR4D2 3275.0
OR13C9 3403.0
OR1E2 3635.0
OR11L1 3856.0
OR2AG2 3965.0
OR11H6 3984.0
OR8D4 4764.0
OR1L8 4766.0
OR4L1 4792.0
OR8G5 4800.0
OR6B2 5006.0
EBF1 5132.0
OR2A25 5362.0
OR5D13 5440.0
OR5B17 5595.0
OR4C3 5647.0
OR56A5 5830.0
OR13J1 5895.0
OR2Z1 6091.0
OR9Q2 6260.0
OR9I1 6545.0
OR4K5 6553.0
OR2M7 6606.0
OR51M1 6711.0
OR6K2 6910.0
GNAL 6927.0
OR2D2 6931.0
OR2AT4 7019.0
RTP1 7037.0
OR2H2 7205.0
OR4M2 7432.0
OR51S1 7615.0
OR2T27 7636.0
OR4C15 7930.0
OR10A5 8093.0
OR51E1 8132.0
OR2T11 8306.0
OR1L4 8788.0
OR2W5 8872.0
OR10K1 8931.0
OR1D2 9324.0
OR10X1 9650.0
ADCY3 9770.0
OR4X1 10189.0
OR8K5 10313.0
OR1N1 10825.0
OR2S2 10832.0
OR10A2 10874.0
OR52L1 11054.0
OR1L1 11223.0
OR2V2 11274.0
OR2F2 11301.0
OR1F1 11439.0
OR5J2 11629.0
OR2AE1 11641.0
OR5A2 12082.0
LHX2 12100.0
CNGA4 12115.0
OR11H2 12259.0
OR9A4 12413.0
OR51G1 12446.0
OR1G1 12459.0
OR4S1 12547.0
OR3A3 12685.0
LDB1 12794.0
OR8B4 12984.0
OR10H5 13076.0
OR4A15 13189.0
OR13A1 13331.0
OR10Z1 13351.0
OR2B11 13393.0
OR52W1 13423.0
OR5B21 13461.0
OR10J3 13598.0
OR2C3 13675.0
OR6N1 13782.0
CNGB1 14697.0
OR4A5 14912.0
OR4C16 14952.0
OR10P1 15124.0
OR2L2 15471.0
OR1S2 15520.0
OR5L1 15697.0
OR51A4 15799.0
OR6K3 15979.0
OR5AR1 16000.0
OR56B1 16282.0
OR2V1 16351.0
OR10R2 16396.0
OR52B2 16410.0
OR2M2 16490.0
OR10H2 16512.0
OR10V1 16587.0
OR51F1 16686.0
OR8B8 16831.0
OR51Q1 16994.0
OR2AP1 17117.0
RTP2 17287.0
OR6C68 17620.0
OR56B4 17811.0
OR2A5 17820.0
OR8G2 18086.0
OR13D1 18192.0
OR4C11 18210.0
OR7G3 18227.0


Viral mRNA Translation

Viral mRNA Translation
1534
set Viral mRNA Translation
setSize 84
pANOVA 1.32e-10
s.dist 0.405
p.adjustANOVA 2.12e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPL35A 17964
RPS27A 17623
RPL34 17570
RPS14 17460
RPL27 17419
RPL18A 17406
RPSA 16750
RPS27 16701
RPS28 16547
RPL32 16401
RPS16 16394
RPL28 16373
RPS10 16101
RPL7 15788
RPS21 15733
RPL29 15716
RPL10L 15577
RPL17 15487
RPS24 15434

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPL35A 17964.0
RPS27A 17623.0
RPL34 17570.0
RPS14 17460.0
RPL27 17419.0
RPL18A 17406.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPL32 16401.0
RPS16 16394.0
RPL28 16373.0
RPS10 16101.0
RPL7 15788.0
RPS21 15733.0
RPL29 15716.0
RPL10L 15577.0
RPL17 15487.0
RPS24 15434.0
RPL23 15404.0
RPS11 15381.0
RPL38 15324.0
RPS26 15184.0
UBA52 15146.0
RPS23 15084.0
RPL24 14927.0
RPS25 14869.0
RPS6 14761.0
RPL9 14519.0
RPS9 14415.0
RPS29 14234.0
RPL26L1 14132.0
RPL30 13945.0
RPL14 13883.0
RPL26 13496.0
RPL7A 13425.0
RPS2 12789.0
RPL12 12744.0
RPL41 12555.0
RPS7 12370.0
RPL37A 11838.0
RPL3L 11730.0
RPS5 11632.0
RPS18 11410.0
RPL13A 11201.5
RPS3A 11123.0
RPL19 10992.0
RPS19 10890.0
RPL13 10808.0
RPS8 10296.0
RPS27L 9869.0
RPL39L 9655.0
RPL18 9621.0
GRSF1 9256.0
RPL23A 8852.0
RPLP1 8689.0
DNAJC3 8665.0
RPLP2 8239.0
RPL37 7695.0
RPS13 7369.0
RPL36AL 7147.0
RPS20 7077.0
RPL4 6779.0
RPL36 6145.0
RPS3 5505.0
RPL8 5310.0
RPL10A 5072.0
RPL15 4446.0
RPL3 4267.0
RPLP0 3455.0
RPS15A 3120.0
RPL11 2419.0
RPS12 2257.0
RPL27A 1306.0
RPL22 1272.0
RPL5 852.0
RPL31 733.0
RPL35 467.0
RPS15 -220.0
RPL21 -682.0
FAU -1469.0
RPL22L1 -1702.0
RPL6 -4235.0


APC/C:Cdc20 mediated degradation of Cyclin B

APC/C:Cdc20 mediated degradation of Cyclin B
13
set APC/C:Cdc20 mediated degradation of Cyclin B
setSize 24
pANOVA 0.000662
s.dist 0.401
p.adjustANOVA 0.0188



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
ANAPC15 16288
UBE2S 15864
CDC20 15528
UBA52 15146
UBB 15063
CDK1 14620
ANAPC7 13840
ANAPC11 13372
ANAPC10 12673
CDC23 12635
ANAPC1 12119
ANAPC2 11107
ANAPC4 10052
UBE2C 7012
CCNB1 6871
CDC16 5961
ANAPC16 5542
UBE2D1 4603

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
ANAPC15 16288
UBE2S 15864
CDC20 15528
UBA52 15146
UBB 15063
CDK1 14620
ANAPC7 13840
ANAPC11 13372
ANAPC10 12673
CDC23 12635
ANAPC1 12119
ANAPC2 11107
ANAPC4 10052
UBE2C 7012
CCNB1 6871
CDC16 5961
ANAPC16 5542
UBE2D1 4603
ANAPC5 3493
UBE2E1 2742
CDC26 2559
CDC27 1689


Eukaryotic Translation Termination

Eukaryotic Translation Termination
401
set Eukaryotic Translation Termination
setSize 87
pANOVA 1.35e-10
s.dist 0.398
p.adjustANOVA 2.12e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPL35A 17964
APEH 17849
RPS27A 17623
RPL34 17570
RPS14 17460
RPL27 17419
RPL18A 17406
RPSA 16750
RPS27 16701
RPS28 16547
RPL32 16401
RPS16 16394
RPL28 16373
RPS10 16101
RPL7 15788
RPS21 15733
RPL29 15716
RPL10L 15577
RPL17 15487

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPL35A 17964.0
APEH 17849.0
RPS27A 17623.0
RPL34 17570.0
RPS14 17460.0
RPL27 17419.0
RPL18A 17406.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPL32 16401.0
RPS16 16394.0
RPL28 16373.0
RPS10 16101.0
RPL7 15788.0
RPS21 15733.0
RPL29 15716.0
RPL10L 15577.0
RPL17 15487.0
RPS24 15434.0
RPL23 15404.0
RPS11 15381.0
RPL38 15324.0
RPS26 15184.0
UBA52 15146.0
RPS23 15084.0
RPL24 14927.0
RPS25 14869.0
RPS6 14761.0
RPL9 14519.0
RPS9 14415.0
RPS29 14234.0
RPL26L1 14132.0
RPL30 13945.0
RPL14 13883.0
RPL26 13496.0
RPL7A 13425.0
RPS2 12789.0
RPL12 12744.0
RPL41 12555.0
RPS7 12370.0
RPL37A 11838.0
RPL3L 11730.0
N6AMT1 11698.0
RPS5 11632.0
RPS18 11410.0
RPL13A 11201.5
RPS3A 11123.0
RPL19 10992.0
RPS19 10890.0
RPL13 10808.0
RPS8 10296.0
RPS27L 9869.0
RPL39L 9655.0
RPL18 9621.0
RPL23A 8852.0
RPLP1 8689.0
RPLP2 8239.0
RPL37 7695.0
RPS13 7369.0
RPL36AL 7147.0
RPS20 7077.0
RPL4 6779.0
RPL36 6145.0
RPS3 5505.0
RPL8 5310.0
RPL10A 5072.0
ETF1 4788.0
RPL15 4446.0
RPL3 4267.0
GSPT1 4234.0
RPLP0 3455.0
RPS15A 3120.0
TRMT112 3046.0
RPL11 2419.0
RPS12 2257.0
RPL27A 1306.0
RPL22 1272.0
RPL5 852.0
RPL31 733.0
RPL35 467.0
RPS15 -220.0
RPL21 -682.0
FAU -1469.0
RPL22L1 -1702.0
RPL6 -4235.0


Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
399
set Eukaryotic Translation Elongation
setSize 88
pANOVA 1.47e-10
s.dist 0.395
p.adjustANOVA 2.12e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPL35A 17964
RPS27A 17623
RPL34 17570
RPS14 17460
RPL27 17419
RPL18A 17406
RPSA 16750
RPS27 16701
RPS28 16547
RPL32 16401
RPS16 16394
RPL28 16373
RPS10 16101
EEF2 15877
RPL7 15788
RPS21 15733
RPL29 15716
RPL10L 15577
RPL17 15487

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPL35A 17964.0
RPS27A 17623.0
RPL34 17570.0
RPS14 17460.0
RPL27 17419.0
RPL18A 17406.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPL32 16401.0
RPS16 16394.0
RPL28 16373.0
RPS10 16101.0
EEF2 15877.0
RPL7 15788.0
RPS21 15733.0
RPL29 15716.0
RPL10L 15577.0
RPL17 15487.0
RPS24 15434.0
RPL23 15404.0
RPS11 15381.0
RPL38 15324.0
RPS26 15184.0
UBA52 15146.0
RPS23 15084.0
RPL24 14927.0
RPS25 14869.0
RPS6 14761.0
RPL9 14519.0
RPS9 14415.0
RPS29 14234.0
RPL26L1 14132.0
RPL30 13945.0
RPL14 13883.0
RPL26 13496.0
RPL7A 13425.0
RPS2 12789.0
RPL12 12744.0
RPL41 12555.0
RPS7 12370.0
RPL37A 11838.0
RPL3L 11730.0
RPS5 11632.0
RPS18 11410.0
RPL13A 11201.5
RPS3A 11123.0
RPL19 10992.0
RPS19 10890.0
RPL13 10808.0
RPS8 10296.0
RPS27L 9869.0
RPL39L 9655.0
RPL18 9621.0
EEF1A1 9096.0
EEF1D 8934.0
RPL23A 8852.0
RPLP1 8689.0
EEF1A2 8347.0
RPLP2 8239.0
EEF1G 8025.0
RPL37 7695.0
RPS13 7369.0
RPL36AL 7147.0
RPS20 7077.0
RPL4 6779.0
RPL36 6145.0
RPS3 5505.0
RPL8 5310.0
RPL10A 5072.0
RPL15 4446.0
RPL3 4267.0
RPLP0 3455.0
RPS15A 3120.0
RPL11 2419.0
RPS12 2257.0
RPL27A 1306.0
RPL22 1272.0
RPL5 852.0
RPL31 733.0
RPL35 467.0
RPS15 -220.0
RPL21 -682.0
FAU -1469.0
EEF1B2 -1647.0
RPL22L1 -1702.0
RPL6 -4235.0


NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
797
set NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
setSize 11
pANOVA 0.0268
s.dist -0.385
p.adjustANOVA 0.225



Top enriched genes

Top 20 genes
GeneID Gene Rank
TRIM4 -6652
RIPK1 -5245
FADD -4998
CASP10 -3558
CHUK -2452
TRIM25 -1856
RNF135 4528
IFIH1 5240
MAVS 5384
CASP8 7096
IKBKB 7359

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRIM4 -6652
RIPK1 -5245
FADD -4998
CASP10 -3558
CHUK -2452
TRIM25 -1856
RNF135 4528
IFIH1 5240
MAVS 5384
CASP8 7096
IKBKB 7359


Selenocysteine synthesis

Selenocysteine synthesis
1239
set Selenocysteine synthesis
setSize 87
pANOVA 1.02e-09
s.dist 0.378
p.adjustANOVA 1.29e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPL35A 17964
RPS27A 17623
RPL34 17570
RPS14 17460
RPL27 17419
RPL18A 17406
RPSA 16750
RPS27 16701
RPS28 16547
RPL32 16401
RPS16 16394
RPL28 16373
RPS10 16101
RPL7 15788
RPS21 15733
RPL29 15716
RPL10L 15577
RPL17 15487
RPS24 15434

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPL35A 17964.0
RPS27A 17623.0
RPL34 17570.0
RPS14 17460.0
RPL27 17419.0
RPL18A 17406.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPL32 16401.0
RPS16 16394.0
RPL28 16373.0
RPS10 16101.0
RPL7 15788.0
RPS21 15733.0
RPL29 15716.0
RPL10L 15577.0
RPL17 15487.0
RPS24 15434.0
RPL23 15404.0
RPS11 15381.0
RPL38 15324.0
RPS26 15184.0
UBA52 15146.0
RPS23 15084.0
RPL24 14927.0
RPS25 14869.0
RPS6 14761.0
RPL9 14519.0
RPS9 14415.0
RPS29 14234.0
RPL26L1 14132.0
RPL30 13945.0
RPL14 13883.0
RPL26 13496.0
RPL7A 13425.0
RPS2 12789.0
RPL12 12744.0
RPL41 12555.0
RPS7 12370.0
RPL37A 11838.0
RPL3L 11730.0
RPS5 11632.0
RPS18 11410.0
RPL13A 11201.5
RPS3A 11123.0
RPL19 10992.0
RPS19 10890.0
RPL13 10808.0
RPS8 10296.0
RPS27L 9869.0
RPL39L 9655.0
RPL18 9621.0
RPL23A 8852.0
RPLP1 8689.0
RPLP2 8239.0
RPL37 7695.0
RPS13 7369.0
RPL36AL 7147.0
RPS20 7077.0
EEFSEC 6881.0
RPL4 6779.0
RPL36 6145.0
RPS3 5505.0
RPL8 5310.0
RPL10A 5072.0
RPL15 4446.0
SEPHS2 4404.0
RPL3 4267.0
SECISBP2 4184.0
RPLP0 3455.0
SEPSECS 3124.0
RPS15A 3120.0
RPL11 2419.0
RPS12 2257.0
RPL27A 1306.0
RPL22 1272.0
PSTK 1189.0
RPL5 852.0
RPL31 733.0
RPL35 467.0
RPS15 -220.0
RPL21 -682.0
FAU -1469.0
RPL22L1 -1702.0
RPL6 -4235.0


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
851
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 89
pANOVA 1.18e-09
s.dist 0.373
p.adjustANOVA 1.29e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPL35A 17964
RPS27A 17623
RPL34 17570
RPS14 17460
RPL27 17419
RPL18A 17406
RPSA 16750
RPS27 16701
RPS28 16547
RPL32 16401
RPS16 16394
RPL28 16373
RPS10 16101
RPL7 15788
RPS21 15733
RPL29 15716
RPL10L 15577
RPL17 15487
RPS24 15434

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPL35A 17964.0
RPS27A 17623.0
RPL34 17570.0
RPS14 17460.0
RPL27 17419.0
RPL18A 17406.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPL32 16401.0
RPS16 16394.0
RPL28 16373.0
RPS10 16101.0
RPL7 15788.0
RPS21 15733.0
RPL29 15716.0
RPL10L 15577.0
RPL17 15487.0
RPS24 15434.0
RPL23 15404.0
RPS11 15381.0
RPL38 15324.0
RPS26 15184.0
UBA52 15146.0
RPS23 15084.0
RPL24 14927.0
RPS25 14869.0
RPS6 14761.0
RPL9 14519.0
RPS9 14415.0
RPS29 14234.0
RPL26L1 14132.0
RPL30 13945.0
RPL14 13883.0
RPL26 13496.0
RPL7A 13425.0
EIF4G1 13114.0
RPS2 12789.0
RPL12 12744.0
RPL41 12555.0
RPS7 12370.0
RPL37A 11838.0
RPL3L 11730.0
RPS5 11632.0
RPS18 11410.0
RPL13A 11201.5
RPS3A 11123.0
RPL19 10992.0
RPS19 10890.0
RPL13 10808.0
RPS8 10296.0
RPS27L 9869.0
RPL39L 9655.0
RPL18 9621.0
UPF1 9418.0
RPL23A 8852.0
RPLP1 8689.0
RPLP2 8239.0
RPL37 7695.0
RPS13 7369.0
RPL36AL 7147.0
RPS20 7077.0
RPL4 6779.0
RPL36 6145.0
RPS3 5505.0
RPL8 5310.0
RPL10A 5072.0
ETF1 4788.0
RPL15 4446.0
RPL3 4267.0
GSPT1 4234.0
RPLP0 3455.0
RPS15A 3120.0
RPL11 2419.0
RPS12 2257.0
PABPC1 1667.0
NCBP1 1531.0
RPL27A 1306.0
RPL22 1272.0
RPL5 852.0
RPL31 733.0
RPL35 467.0
RPS15 -220.0
RPL21 -682.0
NCBP2 -975.0
FAU -1469.0
RPL22L1 -1702.0
RPL6 -4235.0


NRIF signals cell death from the nucleus

NRIF signals cell death from the nucleus
815
set NRIF signals cell death from the nucleus
setSize 16
pANOVA 0.01
s.dist 0.372
p.adjustANOVA 0.126



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 17623
APH1B 17290
UBC 17042
UBA52 15146
UBB 15063
APH1A 14609
PSEN2 13707
TRAF6 9524
NGF 8768
PSEN1 8681
PSENEN 8537
NGFR 7653
ITGB3BP 5286
SQSTM1 5152
NCSTN 2113
MAPK8 -3330

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 17623
APH1B 17290
UBC 17042
UBA52 15146
UBB 15063
APH1A 14609
PSEN2 13707
TRAF6 9524
NGF 8768
PSEN1 8681
PSENEN 8537
NGFR 7653
ITGB3BP 5286
SQSTM1 5152
NCSTN 2113
MAPK8 -3330


TICAM1,TRAF6-dependent induction of TAK1 complex

TICAM1,TRAF6-dependent induction of TAK1 complex
1398
set TICAM1,TRAF6-dependent induction of TAK1 complex
setSize 10
pANOVA 0.0444
s.dist 0.367
p.adjustANOVA 0.296



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
MAP3K7 16345
UBA52 15146
UBB 15063
TLR3 11133
TRAF6 9524
TAB1 2822
TICAM1 812
TAB2 -4298

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
MAP3K7 16345
UBA52 15146
UBB 15063
TLR3 11133
TRAF6 9524
TAB1 2822
TICAM1 812
TAB2 -4298


Intrinsic Pathway of Fibrin Clot Formation

Intrinsic Pathway of Fibrin Clot Formation
662
set Intrinsic Pathway of Fibrin Clot Formation
setSize 21
pANOVA 0.00381
s.dist -0.365
p.adjustANOVA 0.0636



Top enriched genes

Top 20 genes
GeneID Gene Rank
PROS1 -6679
GP5 -5879
SERPINC1 -5768
A2M -4977
F11 -3879
SERPIND1 -3063
SERPINE2 -2989
GP1BA -2009
PROC -1021
KNG1 -830
GP9 213
F12 293
F10 1817
PRCP 2075
VWF 4332
SERPINA5 4505
GP1BB 5527
SERPING1 5568
KLKB1 5924
C1QBP 7179

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PROS1 -6679
GP5 -5879
SERPINC1 -5768
A2M -4977
F11 -3879
SERPIND1 -3063
SERPINE2 -2989
GP1BA -2009
PROC -1021
KNG1 -830
GP9 213
F12 293
F10 1817
PRCP 2075
VWF 4332
SERPINA5 4505
GP1BB 5527
SERPING1 5568
KLKB1 5924
C1QBP 7179
F2 14563


Tandem pore domain potassium channels

Tandem pore domain potassium channels
1425
set Tandem pore domain potassium channels
setSize 12
pANOVA 0.0288
s.dist 0.365
p.adjustANOVA 0.236



Top enriched genes

Top 20 genes
GeneID Gene Rank
KCNK16 17421
KCNK18 16819
KCNK6 14501
KCNK7 13732
KCNK17 12557
KCNK10 11671
KCNK4 10547
KCNK3 9192
KCNK9 8381
KCNK1 4007
KCNK13 1366
KCNK2 866

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KCNK16 17421
KCNK18 16819
KCNK6 14501
KCNK7 13732
KCNK17 12557
KCNK10 11671
KCNK4 10547
KCNK3 9192
KCNK9 8381
KCNK1 4007
KCNK13 1366
KCNK2 866


Regulation of IFNA/IFNB signaling

Regulation of IFNA/IFNB signaling
1117
set Regulation of IFNA/IFNB signaling
setSize 22
pANOVA 0.00331
s.dist -0.362
p.adjustANOVA 0.0584



Top enriched genes

Top 20 genes
GeneID Gene Rank
IFNA6 -7454
IFNA16 -7423
IFNA2 -7251
IFNA21 -7180
IFNA14 -7099
IFNB1 -7088
IFNA1 -7038
IFNA5 -5828
PTPN11 -5020
IFNA7 -4450
STAT1 -4154
IFNA8 -2780
JAK1 -1659
STAT2 4463
IFNAR2 5854
TYK2 6414
SOCS3 7430
PTPN1 10443
PTPN6 11736
IFNAR1 13771

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IFNA6 -7454
IFNA16 -7423
IFNA2 -7251
IFNA21 -7180
IFNA14 -7099
IFNB1 -7088
IFNA1 -7038
IFNA5 -5828
PTPN11 -5020
IFNA7 -4450
STAT1 -4154
IFNA8 -2780
JAK1 -1659
STAT2 4463
IFNAR2 5854
TYK2 6414
SOCS3 7430
PTPN1 10443
PTPN6 11736
IFNAR1 13771
USP18 14882
SOCS1 15898


Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
1176
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 95
pANOVA 1.17e-09
s.dist 0.361
p.adjustANOVA 1.29e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPL35A 17964
RPS27A 17623
RPL34 17570
RPS14 17460
RPL27 17419
RPL18A 17406
RPSA 16750
RPS27 16701
RPS28 16547
RPL32 16401
RPS16 16394
RPL28 16373
RPS10 16101
RPL7 15788
RPS21 15733
RPL29 15716
RPL10L 15577
RPL17 15487
RPS24 15434

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPL35A 17964.0
RPS27A 17623.0
RPL34 17570.0
RPS14 17460.0
RPL27 17419.0
RPL18A 17406.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPL32 16401.0
RPS16 16394.0
RPL28 16373.0
RPS10 16101.0
RPL7 15788.0
RPS21 15733.0
RPL29 15716.0
RPL10L 15577.0
RPL17 15487.0
RPS24 15434.0
RPL23 15404.0
ATF2 15388.0
RPS11 15381.0
RPL38 15324.0
RPS26 15184.0
UBA52 15146.0
RPS23 15084.0
RPL24 14927.0
RPS25 14869.0
RPS6 14761.0
RPL9 14519.0
RPS9 14415.0
RPS29 14234.0
RPL26L1 14132.0
RPL30 13945.0
RPL14 13883.0
RPL26 13496.0
RPL7A 13425.0
DDIT3 13284.0
GCN1 13237.0
RPS2 12789.0
RPL12 12744.0
RPL41 12555.0
RPS7 12370.0
CEBPG 12189.0
RPL37A 11838.0
RPL3L 11730.0
RPS5 11632.0
EIF2AK4 11475.0
RPS18 11410.0
RPL13A 11201.5
RPS3A 11123.0
RPL19 10992.0
RPS19 10890.0
RPL13 10808.0
RPS8 10296.0
RPS27L 9869.0
RPL39L 9655.0
RPL18 9621.0
RPL23A 8852.0
RPLP1 8689.0
RPLP2 8239.0
ASNS 7915.0
RPL37 7695.0
RPS13 7369.0
RPL36AL 7147.0
RPS20 7077.0
RPL4 6779.0
RPL36 6145.0
RPS3 5505.0
RPL8 5310.0
RPL10A 5072.0
ATF4 4664.0
RPL15 4446.0
RPL3 4267.0
RPLP0 3455.0
RPS15A 3120.0
CEBPB 2992.0
RPL11 2419.0
RPS12 2257.0
EIF2S1 1847.0
ATF3 1514.0
RPL27A 1306.0
RPL22 1272.0
RPL5 852.0
RPL31 733.0
TRIB3 530.0
RPL35 467.0
RPS15 -220.0
RPL21 -682.0
EIF2S2 -941.0
FAU -1469.0
RPL22L1 -1702.0
IMPACT -3793.0
RPL6 -4235.0


Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
454
set Formation of a pool of free 40S subunits
setSize 94
pANOVA 1.71e-09
s.dist 0.359
p.adjustANOVA 1.69e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPL35A 17964
EIF3G 17865
RPS27A 17623
RPL34 17570
RPS14 17460
RPL27 17419
RPL18A 17406
RPSA 16750
RPS27 16701
RPS28 16547
RPL32 16401
RPS16 16394
RPL28 16373
RPS10 16101
RPL7 15788
RPS21 15733
RPL29 15716
RPL10L 15577
RPL17 15487

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPL35A 17964.0
EIF3G 17865.0
RPS27A 17623.0
RPL34 17570.0
RPS14 17460.0
RPL27 17419.0
RPL18A 17406.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPL32 16401.0
RPS16 16394.0
RPL28 16373.0
RPS10 16101.0
RPL7 15788.0
RPS21 15733.0
RPL29 15716.0
RPL10L 15577.0
RPL17 15487.0
RPS24 15434.0
RPL23 15404.0
RPS11 15381.0
RPL38 15324.0
RPS26 15184.0
UBA52 15146.0
RPS23 15084.0
RPL24 14927.0
RPS25 14869.0
RPS6 14761.0
EIF3D 14542.0
RPL9 14519.0
RPS9 14415.0
RPS29 14234.0
RPL26L1 14132.0
RPL30 13945.0
RPL14 13883.0
RPL26 13496.0
RPL7A 13425.0
EIF3I 12960.0
RPS2 12789.0
RPL12 12744.0
RPL41 12555.0
RPS7 12370.0
RPL37A 11838.0
RPL3L 11730.0
RPS5 11632.0
RPS18 11410.0
RPL13A 11201.5
RPS3A 11123.0
RPL19 10992.0
RPS19 10890.0
RPL13 10808.0
RPS8 10296.0
RPS27L 9869.0
RPL39L 9655.0
RPL18 9621.0
RPL23A 8852.0
RPLP1 8689.0
RPLP2 8239.0
RPL37 7695.0
EIF3B 7424.0
RPS13 7369.0
RPL36AL 7147.0
RPS20 7077.0
RPL4 6779.0
EIF3J 6721.0
EIF3E 6441.0
RPL36 6145.0
RPS3 5505.0
RPL8 5310.0
RPL10A 5072.0
EIF3K 4535.0
RPL15 4446.0
RPL3 4267.0
EIF3L 3545.0
RPLP0 3455.0
EIF3F 3217.0
RPS15A 3120.0
RPL11 2419.0
RPS12 2257.0
RPL27A 1306.0
RPL22 1272.0
RPL5 852.0
RPL31 733.0
RPL35 467.0
RPS15 -220.0
RPL21 -682.0
FAU -1469.0
EIF3H -1690.0
RPL22L1 -1702.0
EIF3A -3383.0
EIF3M -3931.0
RPL6 -4235.0


Signaling by cytosolic FGFR1 fusion mutants

Signaling by cytosolic FGFR1 fusion mutants
1342
set Signaling by cytosolic FGFR1 fusion mutants
setSize 17
pANOVA 0.0108
s.dist -0.357
p.adjustANOVA 0.131



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZMYM2 -5435
STAT1 -4154
TRIM24 -3939
STAT5A -3538
STAT5B -2708
GAB2 -2592
CNTRL -974
CUX1 -850
STAT3 454
LRRFIP1 987
FGFR1OP2 1031
GRB2 3241
CPSF6 3376
PIK3CA 5249
BCR 7309
MYO18A 7475
PIK3R1 8833

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZMYM2 -5435
STAT1 -4154
TRIM24 -3939
STAT5A -3538
STAT5B -2708
GAB2 -2592
CNTRL -974
CUX1 -850
STAT3 454
LRRFIP1 987
FGFR1OP2 1031
GRB2 3241
CPSF6 3376
PIK3CA 5249
BCR 7309
MYO18A 7475
PIK3R1 8833


Sensory perception of sweet, bitter, and umami (glutamate) taste

Sensory perception of sweet, bitter, and umami (glutamate) taste
1246
set Sensory perception of sweet, bitter, and umami (glutamate) taste
setSize 41
pANOVA 7.68e-05
s.dist -0.357
p.adjustANOVA 0.00244



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAS2R46 -7339
TAS2R10 -7306
TAS2R4 -7233
TAS2R14 -6983
TAS2R50 -6656
TAS2R8 -6601
TAS2R43 -6600
TAS2R39 -6469
TAS2R13 -6411
TAS2R3 -6389
TAS2R31 -5781
TAS2R30 -5769
TAS2R5 -5318
GNAT3 -4554
TAS2R7 -4436
TAS2R16 -4099
GNG13 -4054
TAS2R1 -3267
TAS2R38 -2766
SCN3A -1615

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAS2R46 -7339
TAS2R10 -7306
TAS2R4 -7233
TAS2R14 -6983
TAS2R50 -6656
TAS2R8 -6601
TAS2R43 -6600
TAS2R39 -6469
TAS2R13 -6411
TAS2R3 -6389
TAS2R31 -5781
TAS2R30 -5769
TAS2R5 -5318
GNAT3 -4554
TAS2R7 -4436
TAS2R16 -4099
GNG13 -4054
TAS2R1 -3267
TAS2R38 -2766
SCN3A -1615
TAS1R2 -767
TAS2R20 -749
GRM1 2427
GNB1 2634
SCN9A 2744
CALHM1 2907
PLCB2 3318
SCN2B 3609
CALHM3 4068
TAS1R3 5729
TAS2R40 7295
SCN2A 7350
GNB3 7987
SCN4B 8832
GRM4 8862
TAS2R41 9019
ITPR3 10927
TRPM5 11997
TRPM4 13148
SCN1B 14870
TAS1R1 16838


Pausing and recovery of Tat-mediated HIV elongation

Pausing and recovery of Tat-mediated HIV elongation
925
set Pausing and recovery of Tat-mediated HIV elongation
setSize 27
pANOVA 0.00137
s.dist 0.356
p.adjustANOVA 0.0311



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2K 18005
SUPT5H 17546
POLR2J 17537
NELFB 17306
CDK9 16364
TCEA1 16072
POLR2E 15351
SUPT4H1 15226
POLR2D 15138
SSRP1 14710
CCNT1 13227
POLR2H 11868
POLR2L 11588
POLR2F 11205
POLR2I 10571
ELL 9284
NELFA 7707
POLR2A 7258
POLR2B 5067
NELFE 5043

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2K 18005
SUPT5H 17546
POLR2J 17537
NELFB 17306
CDK9 16364
TCEA1 16072
POLR2E 15351
SUPT4H1 15226
POLR2D 15138
SSRP1 14710
CCNT1 13227
POLR2H 11868
POLR2L 11588
POLR2F 11205
POLR2I 10571
ELL 9284
NELFA 7707
POLR2A 7258
POLR2B 5067
NELFE 5043
POLR2C 4753
POLR2G 3709
SUPT16H 2892
CTDP1 2574
NELFCD 1651
GTF2F1 269
GTF2F2 -2649


Tat-mediated HIV elongation arrest and recovery

Tat-mediated HIV elongation arrest and recovery
1426
set Tat-mediated HIV elongation arrest and recovery
setSize 27
pANOVA 0.00137
s.dist 0.356
p.adjustANOVA 0.0311



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2K 18005
SUPT5H 17546
POLR2J 17537
NELFB 17306
CDK9 16364
TCEA1 16072
POLR2E 15351
SUPT4H1 15226
POLR2D 15138
SSRP1 14710
CCNT1 13227
POLR2H 11868
POLR2L 11588
POLR2F 11205
POLR2I 10571
ELL 9284
NELFA 7707
POLR2A 7258
POLR2B 5067
NELFE 5043

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2K 18005
SUPT5H 17546
POLR2J 17537
NELFB 17306
CDK9 16364
TCEA1 16072
POLR2E 15351
SUPT4H1 15226
POLR2D 15138
SSRP1 14710
CCNT1 13227
POLR2H 11868
POLR2L 11588
POLR2F 11205
POLR2I 10571
ELL 9284
NELFA 7707
POLR2A 7258
POLR2B 5067
NELFE 5043
POLR2C 4753
POLR2G 3709
SUPT16H 2892
CTDP1 2574
NELFCD 1651
GTF2F1 269
GTF2F2 -2649


Caspase activation via Death Receptors in the presence of ligand

Caspase activation via Death Receptors in the presence of ligand
175
set Caspase activation via Death Receptors in the presence of ligand
setSize 16
pANOVA 0.0142
s.dist -0.354
p.adjustANOVA 0.155



Top enriched genes

Top 20 genes
GeneID Gene Rank
LY96 -6864
CD14 -5904
FASLG -5653
RIPK1 -5245
FADD -4998
TLR4 -1575
TICAM2 -1504
TNFRSF10A -1218
TNFRSF10B 716
TICAM1 812
TNFSF10 1565
CFLAR 4199
CASP8 7096
FAS 7842
TRAF2 8353
TRADD 15909

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LY96 -6864
CD14 -5904
FASLG -5653
RIPK1 -5245
FADD -4998
TLR4 -1575
TICAM2 -1504
TNFRSF10A -1218
TNFRSF10B 716
TICAM1 812
TNFSF10 1565
CFLAR 4199
CASP8 7096
FAS 7842
TRAF2 8353
TRADD 15909


p75NTR recruits signalling complexes

p75NTR recruits signalling complexes
1576
set p75NTR recruits signalling complexes
setSize 12
pANOVA 0.0356
s.dist 0.35
p.adjustANOVA 0.258



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
UBA52 15146
UBB 15063
MYD88 10379
TRAF6 9524
NGF 8768
NGFR 7653
IKBKB 7359
PRKCI 5995
SQSTM1 5152
RIPK2 -840

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS27A 17623
UBC 17042
UBA52 15146
UBB 15063
MYD88 10379
TRAF6 9524
NGF 8768
NGFR 7653
IKBKB 7359
PRKCI 5995
SQSTM1 5152
RIPK2 -840


HIV elongation arrest and recovery

HIV elongation arrest and recovery
564
set HIV elongation arrest and recovery
setSize 29
pANOVA 0.00116
s.dist 0.348
p.adjustANOVA 0.0281



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2K 18005
SUPT5H 17546
POLR2J 17537
NELFB 17306
CDK9 16364
TCEA1 16072
POLR2E 15351
SUPT4H1 15226
POLR2D 15138
SSRP1 14710
CCNT1 13227
POLR2H 11868
CCNK 11598
POLR2L 11588
POLR2F 11205
POLR2I 10571
ELL 9284
NELFA 7707
POLR2A 7258
CCNT2 5581

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2K 18005
SUPT5H 17546
POLR2J 17537
NELFB 17306
CDK9 16364
TCEA1 16072
POLR2E 15351
SUPT4H1 15226
POLR2D 15138
SSRP1 14710
CCNT1 13227
POLR2H 11868
CCNK 11598
POLR2L 11588
POLR2F 11205
POLR2I 10571
ELL 9284
NELFA 7707
POLR2A 7258
CCNT2 5581
POLR2B 5067
NELFE 5043
POLR2C 4753
POLR2G 3709
SUPT16H 2892
CTDP1 2574
NELFCD 1651
GTF2F1 269
GTF2F2 -2649


Pausing and recovery of HIV elongation

Pausing and recovery of HIV elongation
924
set Pausing and recovery of HIV elongation
setSize 29
pANOVA 0.00116
s.dist 0.348
p.adjustANOVA 0.0281



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2K 18005
SUPT5H 17546
POLR2J 17537
NELFB 17306
CDK9 16364
TCEA1 16072
POLR2E 15351
SUPT4H1 15226
POLR2D 15138
SSRP1 14710
CCNT1 13227
POLR2H 11868
CCNK 11598
POLR2L 11588
POLR2F 11205
POLR2I 10571
ELL 9284
NELFA 7707
POLR2A 7258
CCNT2 5581

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2K 18005
SUPT5H 17546
POLR2J 17537
NELFB 17306
CDK9 16364
TCEA1 16072
POLR2E 15351
SUPT4H1 15226
POLR2D 15138
SSRP1 14710
CCNT1 13227
POLR2H 11868
CCNK 11598
POLR2L 11588
POLR2F 11205
POLR2I 10571
ELL 9284
NELFA 7707
POLR2A 7258
CCNT2 5581
POLR2B 5067
NELFE 5043
POLR2C 4753
POLR2G 3709
SUPT16H 2892
CTDP1 2574
NELFCD 1651
GTF2F1 269
GTF2F2 -2649


Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
466
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 46
pANOVA 4.47e-05
s.dist 0.348
p.adjustANOVA 0.00158



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
EIF3G 17865
RPS27A 17623
RPS14 17460
RPSA 16750
RPS27 16701
RPS28 16547
RPS16 16394
RPS10 16101
RPS21 15733
RPS24 15434
RPS11 15381
RPS26 15184
RPS23 15084
RPS25 14869
RPS6 14761
EIF3D 14542
RPS9 14415
RPS29 14234
EIF3I 12960

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998
EIF3G 17865
RPS27A 17623
RPS14 17460
RPSA 16750
RPS27 16701
RPS28 16547
RPS16 16394
RPS10 16101
RPS21 15733
RPS24 15434
RPS11 15381
RPS26 15184
RPS23 15084
RPS25 14869
RPS6 14761
EIF3D 14542
RPS9 14415
RPS29 14234
EIF3I 12960
RPS2 12789
RPS7 12370
RPS5 11632
RPS18 11410
RPS3A 11123
RPS19 10890
RPS8 10296
RPS27L 9869
EIF3B 7424
RPS13 7369
RPS20 7077
EIF3J 6721
EIF3E 6441
RPS3 5505
EIF3K 4535
EIF3L 3545
EIF3F 3217
RPS15A 3120
RPS12 2257
EIF2S1 1847
RPS15 -220
EIF2S2 -941
FAU -1469
EIF3H -1690
EIF3A -3383
EIF3M -3931


NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus
809
set NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize 11
pANOVA 0.0467
s.dist 0.346
p.adjustANOVA 0.297



Top enriched genes

Top 20 genes
GeneID Gene Rank
APH1B 17290
YWHAZ 15102
APH1A 14609
DLL4 13911
PSEN2 13707
PSEN1 8681
PSENEN 8537
JAG1 7042
NOTCH4 4531
ADAM10 2882
NCSTN 2113

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APH1B 17290
YWHAZ 15102
APH1A 14609
DLL4 13911
PSEN2 13707
PSEN1 8681
PSENEN 8537
JAG1 7042
NOTCH4 4531
ADAM10 2882
NCSTN 2113


Interleukin-15 signaling

Interleukin-15 signaling
644
set Interleukin-15 signaling
setSize 13
pANOVA 0.0308
s.dist -0.346
p.adjustANOVA 0.244



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAT5A -3538
SOS2 -3122
STAT5B -2708
GAB2 -2592
SOS1 -2269
JAK1 -1659
IL15 -1584
STAT3 454
GRB2 3241
IL15RA 3385
IL2RB 6203
SHC1 7057
JAK3 9478

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT5A -3538
SOS2 -3122
STAT5B -2708
GAB2 -2592
SOS1 -2269
JAK1 -1659
IL15 -1584
STAT3 454
GRB2 3241
IL15RA 3385
IL2RB 6203
SHC1 7057
JAK3 9478


SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery
1200
set SARS-CoV-2 modulates host translation machinery
setSize 46
pANOVA 6.31e-05
s.dist 0.341
p.adjustANOVA 0.00204



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPS27A 17623
RPS14 17460
GEMIN4 17233
GEMIN6 17215
RPSA 16750
RPS27 16701
RPS28 16547
RPS16 16394
RPS10 16101
RPS21 15733
RPS24 15434
RPS11 15381
RPS26 15184
RPS23 15084
RPS25 14869
RPS6 14761
RPS9 14415
RPS29 14234
RPS2 12789

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPS27A 17623.0
RPS14 17460.0
GEMIN4 17233.0
GEMIN6 17215.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPS16 16394.0
RPS10 16101.0
RPS21 15733.0
RPS24 15434.0
RPS11 15381.0
RPS26 15184.0
RPS23 15084.0
RPS25 14869.0
RPS6 14761.0
RPS9 14415.0
RPS29 14234.0
RPS2 12789.0
RPS7 12370.0
SNRPE 11674.0
RPS5 11632.0
RPS18 11410.0
RPS3A 11123.0
RPS19 10890.0
RPS8 10296.0
SNRPD2 9917.0
RPS27L 9869.0
SNRPB 7901.0
SNRPD1 7756.0
RPS13 7369.0
RPS20 7077.0
SNRPF 6044.0
RPS3 5505.0
SNRPG 4432.0
RPS15A 3120.0
SNRPD3 2542.0
RPS12 2257.0
GEMIN5 544.0
RPS15 -220.0
FAU -1469.0
DDX20 -2110.0
GEMIN2 -4722.0
GEMIN7 -5985.0
SMN1 -7354.5


Selenoamino acid metabolism

Selenoamino acid metabolism
1238
set Selenoamino acid metabolism
setSize 103
pANOVA 3.25e-09
s.dist 0.337
p.adjustANOVA 2.72e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPL35A 17964
RPS27A 17623
RPL34 17570
RPS14 17460
RPL27 17419
RPL18A 17406
RPSA 16750
RPS27 16701
RPS28 16547
RPL32 16401
RPS16 16394
RPL28 16373
RPS10 16101
RPL7 15788
RPS21 15733
RPL29 15716
RPL10L 15577
RPL17 15487
RPS24 15434

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPL35A 17964.0
RPS27A 17623.0
RPL34 17570.0
RPS14 17460.0
RPL27 17419.0
RPL18A 17406.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPL32 16401.0
RPS16 16394.0
RPL28 16373.0
RPS10 16101.0
RPL7 15788.0
RPS21 15733.0
RPL29 15716.0
RPL10L 15577.0
RPL17 15487.0
RPS24 15434.0
RPL23 15404.0
RPS11 15381.0
RPL38 15324.0
RPS26 15184.0
UBA52 15146.0
RPS23 15084.0
GSR 15015.0
RPL24 14927.0
RPS25 14869.0
RPS6 14761.0
GNMT 14576.0
RPL9 14519.0
RPS9 14415.0
RPS29 14234.0
RPL26L1 14132.0
RPL30 13945.0
RPL14 13883.0
RPL26 13496.0
RPL7A 13425.0
MAT1A 13366.0
RPS2 12789.0
RPL12 12744.0
RPL41 12555.0
RPS7 12370.0
RPL37A 11838.0
RPL3L 11730.0
RPS5 11632.0
RPS18 11410.0
RPL13A 11201.5
RPS3A 11123.0
RPL19 10992.0
RPS19 10890.0
RPL13 10808.0
RPS8 10296.0
TXNRD1 10171.0
AHCY 10121.0
CTH 10038.0
PAPSS2 9945.0
RPS27L 9869.0
RPL39L 9655.0
RPL18 9621.0
RPL23A 8852.0
RPLP1 8689.0
RPLP2 8239.0
NNMT 7725.0
RPL37 7695.0
RPS13 7369.0
RPL36AL 7147.0
RPS20 7077.0
PAPSS1 7051.0
EEFSEC 6881.0
RPL4 6779.0
CBS 6598.0
RPL36 6145.0
RPS3 5505.0
RPL8 5310.0
RPL10A 5072.0
RPL15 4446.0
SEPHS2 4404.0
INMT 4311.0
RPL3 4267.0
SECISBP2 4184.0
RPLP0 3455.0
HNMT 3216.0
SEPSECS 3124.0
RPS15A 3120.0
RPL11 2419.0
RPS12 2257.0
AIMP1 1642.0
RPL27A 1306.0
RPL22 1272.0
PSTK 1189.0
RPL5 852.0
RPL31 733.0
RPL35 467.0
RPS15 -220.0
RPL21 -682.0
AIMP2 -702.0
FAU -1469.0
EEF1E1 -1527.0
RPL22L1 -1702.0
SCLY -2228.0
RPL6 -4235.0


Attenuation phase

Attenuation phase
106
set Attenuation phase
setSize 25
pANOVA 0.00351
s.dist 0.337
p.adjustANOVA 0.0593



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSPA1B 17619
DNAJB1 17407
RLN1 16258
SERPINH1 15956
HSPA6 15776
HSPA1A 15149
UBB 15063
HSBP1 14924
HSPA2 14666
HSP90AA1 14304
PTGES3 13287
CRYBA4 13066
FKBP4 12309
HSF1 10287
HSPA8 10210
HSPA1L 7148
GML 5432
DEDD2 4935
HSPH1 4283
MRPL18 3284

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA1B 17619
DNAJB1 17407
RLN1 16258
SERPINH1 15956
HSPA6 15776
HSPA1A 15149
UBB 15063
HSBP1 14924
HSPA2 14666
HSP90AA1 14304
PTGES3 13287
CRYBA4 13066
FKBP4 12309
HSF1 10287
HSPA8 10210
HSPA1L 7148
GML 5432
DEDD2 4935
HSPH1 4283
MRPL18 3284
TNFRSF21 2226
CREBBP 955
HSP90AB1 555
EP300 381
DNAJB6 -2121


Chylomicron assembly

Chylomicron assembly
209
set Chylomicron assembly
setSize 10
pANOVA 0.0652
s.dist 0.337
p.adjustANOVA 0.338



Top enriched genes

Top 20 genes
GeneID Gene Rank
APOA2 17615
APOC3 15561
APOC2 14895
APOA1 12062
APOA4 10060
APOE 9123
MTTP 9001
SAR1B 7480
APOB 3390
P4HB -1886

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
APOA2 17615
APOC3 15561
APOC2 14895
APOA1 12062
APOA4 10060
APOE 9123
MTTP 9001
SAR1B 7480
APOB 3390
P4HB -1886


L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
679
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 103
pANOVA 4.02e-09
s.dist 0.335
p.adjustANOVA 3.03e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPL35A 17964
EIF3G 17865
RPS27A 17623
RPL34 17570
RPS14 17460
RPL27 17419
RPL18A 17406
RPSA 16750
RPS27 16701
RPS28 16547
RPL32 16401
RPS16 16394
RPL28 16373
RPS10 16101
RPL7 15788
RPS21 15733
RPL29 15716
RPL10L 15577
RPL17 15487

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPL35A 17964.0
EIF3G 17865.0
RPS27A 17623.0
RPL34 17570.0
RPS14 17460.0
RPL27 17419.0
RPL18A 17406.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPL32 16401.0
RPS16 16394.0
RPL28 16373.0
RPS10 16101.0
RPL7 15788.0
RPS21 15733.0
RPL29 15716.0
RPL10L 15577.0
RPL17 15487.0
RPS24 15434.0
RPL23 15404.0
RPS11 15381.0
RPL38 15324.0
RPS26 15184.0
UBA52 15146.0
RPS23 15084.0
RPL24 14927.0
RPS25 14869.0
RPS6 14761.0
EIF3D 14542.0
RPL9 14519.0
RPS9 14415.0
EIF4A2 14275.0
RPS29 14234.0
RPL26L1 14132.0
RPL30 13945.0
RPL14 13883.0
RPL26 13496.0
RPL7A 13425.0
EIF4G1 13114.0
EIF4E 13005.0
EIF3I 12960.0
RPS2 12789.0
RPL12 12744.0
RPL41 12555.0
RPS7 12370.0
RPL37A 11838.0
RPL3L 11730.0
RPS5 11632.0
RPS18 11410.0
RPL13A 11201.5
RPS3A 11123.0
RPL19 10992.0
RPS19 10890.0
RPL13 10808.0
RPS8 10296.0
RPS27L 9869.0
RPL39L 9655.0
RPL18 9621.0
RPL23A 8852.0
RPLP1 8689.0
RPLP2 8239.0
RPL37 7695.0
EIF3B 7424.0
RPS13 7369.0
RPL36AL 7147.0
RPS20 7077.0
RPL4 6779.0
EIF4B 6741.0
EIF3J 6721.0
EIF3E 6441.0
RPL36 6145.0
EIF4H 6065.0
RPS3 5505.0
RPL8 5310.0
RPL10A 5072.0
EIF3K 4535.0
RPL15 4446.0
RPL3 4267.0
EIF3L 3545.0
RPLP0 3455.0
EIF3F 3217.0
RPS15A 3120.0
EIF4A1 2463.0
RPL11 2419.0
RPS12 2257.0
EIF2S1 1847.0
PABPC1 1667.0
RPL27A 1306.0
RPL22 1272.0
RPL5 852.0
RPL31 733.0
RPL35 467.0
RPS15 -220.0
RPL21 -682.0
EIF2S2 -941.0
FAU -1469.0
EIF3H -1690.0
RPL22L1 -1702.0
EIF3A -3383.0
EIF3M -3931.0
RPL6 -4235.0


GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
505
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 104
pANOVA 3.93e-09
s.dist 0.334
p.adjustANOVA 3.03e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
RPL35A 17964
EIF3G 17865
RPS27A 17623
RPL34 17570
RPS14 17460
RPL27 17419
RPL18A 17406
RPSA 16750
RPS27 16701
RPS28 16547
RPL32 16401
RPS16 16394
RPL28 16373
RPS10 16101
RPL7 15788
RPS21 15733
RPL29 15716
RPL10L 15577
RPL17 15487

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998.0
RPL35A 17964.0
EIF3G 17865.0
RPS27A 17623.0
RPL34 17570.0
RPS14 17460.0
RPL27 17419.0
RPL18A 17406.0
RPSA 16750.0
RPS27 16701.0
RPS28 16547.0
RPL32 16401.0
RPS16 16394.0
RPL28 16373.0
RPS10 16101.0
RPL7 15788.0
RPS21 15733.0
RPL29 15716.0
RPL10L 15577.0
RPL17 15487.0
RPS24 15434.0
RPL23 15404.0
RPS11 15381.0
RPL38 15324.0
RPS26 15184.0
UBA52 15146.0
RPS23 15084.0
RPL24 14927.0
RPS25 14869.0
RPS6 14761.0
EIF3D 14542.0
RPL9 14519.0
RPS9 14415.0
EIF4A2 14275.0
RPS29 14234.0
RPL26L1 14132.0
RPL30 13945.0
RPL14 13883.0
RPL26 13496.0
RPL7A 13425.0
EIF4G1 13114.0
EIF4E 13005.0
EIF3I 12960.0
RPS2 12789.0
RPL12 12744.0
RPL41 12555.0
RPS7 12370.0
RPL37A 11838.0
RPL3L 11730.0
RPS5 11632.0
RPS18 11410.0
RPL13A 11201.5
RPS3A 11123.0
RPL19 10992.0
RPS19 10890.0
RPL13 10808.0
RPS8 10296.0
RPS27L 9869.0
RPL39L 9655.0
RPL18 9621.0
RPL23A 8852.0
RPLP1 8689.0
RPLP2 8239.0
RPL37 7695.0
EIF3B 7424.0
RPS13 7369.0
RPL36AL 7147.0
RPS20 7077.0
RPL4 6779.0
EIF4B 6741.0
EIF3J 6721.0
EIF5B 6601.0
EIF3E 6441.0
RPL36 6145.0
EIF4H 6065.0
RPS3 5505.0
RPL8 5310.0
RPL10A 5072.0
EIF3K 4535.0
RPL15 4446.0
RPL3 4267.0
EIF3L 3545.0
RPLP0 3455.0
EIF3F 3217.0
RPS15A 3120.0
EIF5 2884.0
EIF4A1 2463.0
RPL11 2419.0
RPS12 2257.0
EIF2S1 1847.0
RPL27A 1306.0
RPL22 1272.0
RPL5 852.0
RPL31 733.0
RPL35 467.0
RPS15 -220.0
RPL21 -682.0
EIF2S2 -941.0
FAU -1469.0
EIF3H -1690.0
RPL22L1 -1702.0
EIF3A -3383.0
EIF3M -3931.0
RPL6 -4235.0


Biosynthesis of DHA-derived SPMs

Biosynthesis of DHA-derived SPMs
127
set Biosynthesis of DHA-derived SPMs
setSize 17
pANOVA 0.0173
s.dist 0.334
p.adjustANOVA 0.172



Top enriched genes

Top 20 genes
GeneID Gene Rank
PTGS2 17868
CYP2E1 17310
ALOX12 17279
CYP1A2 15894
CYP2D6 14012
GPX4 12680
CYP3A4 11967
LTC4S 10798
GSTM4 10453
ALOX5 9755
HPGD 9371
LTA4H 8036
ALOX15 7416
CYP1A1 7088
EPHX2 5655
CYP2C8 -5402
CYP2C9 -5476

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTGS2 17868
CYP2E1 17310
ALOX12 17279
CYP1A2 15894
CYP2D6 14012
GPX4 12680
CYP3A4 11967
LTC4S 10798
GSTM4 10453
ALOX5 9755
HPGD 9371
LTA4H 8036
ALOX15 7416
CYP1A1 7088
EPHX2 5655
CYP2C8 -5402
CYP2C9 -5476


Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
1187
set Ribosomal scanning and start codon recognition
setSize 53
pANOVA 2.82e-05
s.dist 0.332
p.adjustANOVA 0.00109



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
EIF3G 17865
RPS27A 17623
RPS14 17460
RPSA 16750
RPS27 16701
RPS28 16547
RPS16 16394
RPS10 16101
RPS21 15733
RPS24 15434
RPS11 15381
RPS26 15184
RPS23 15084
RPS25 14869
RPS6 14761
EIF3D 14542
RPS9 14415
EIF4A2 14275
RPS29 14234

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998
EIF3G 17865
RPS27A 17623
RPS14 17460
RPSA 16750
RPS27 16701
RPS28 16547
RPS16 16394
RPS10 16101
RPS21 15733
RPS24 15434
RPS11 15381
RPS26 15184
RPS23 15084
RPS25 14869
RPS6 14761
EIF3D 14542
RPS9 14415
EIF4A2 14275
RPS29 14234
EIF4G1 13114
EIF4E 13005
EIF3I 12960
RPS2 12789
RPS7 12370
RPS5 11632
RPS18 11410
RPS3A 11123
RPS19 10890
RPS8 10296
RPS27L 9869
EIF3B 7424
RPS13 7369
RPS20 7077
EIF4B 6741
EIF3J 6721
EIF3E 6441
EIF4H 6065
RPS3 5505
EIF3K 4535
EIF3L 3545
EIF3F 3217
RPS15A 3120
EIF5 2884
EIF4A1 2463
RPS12 2257
EIF2S1 1847
RPS15 -220
EIF2S2 -941
FAU -1469
EIF3H -1690
EIF3A -3383
EIF3M -3931


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
54
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 54
pANOVA 2.39e-05
s.dist 0.332
p.adjustANOVA 0.000972



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS17 17998
EIF3G 17865
RPS27A 17623
RPS14 17460
RPSA 16750
RPS27 16701
RPS28 16547
RPS16 16394
RPS10 16101
RPS21 15733
RPS24 15434
RPS11 15381
RPS26 15184
RPS23 15084
RPS25 14869
RPS6 14761
EIF3D 14542
RPS9 14415
EIF4A2 14275
RPS29 14234

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS17 17998
EIF3G 17865
RPS27A 17623
RPS14 17460
RPSA 16750
RPS27 16701
RPS28 16547
RPS16 16394
RPS10 16101
RPS21 15733
RPS24 15434
RPS11 15381
RPS26 15184
RPS23 15084
RPS25 14869
RPS6 14761
EIF3D 14542
RPS9 14415
EIF4A2 14275
RPS29 14234
EIF4G1 13114
EIF4E 13005
EIF3I 12960
RPS2 12789
RPS7 12370
RPS5 11632
RPS18 11410
RPS3A 11123
RPS19 10890
EIF4EBP1 10805
RPS8 10296
RPS27L 9869
EIF3B 7424
RPS13 7369
RPS20 7077
EIF4B 6741
EIF3J 6721
EIF3E 6441
EIF4H 6065
RPS3 5505
EIF3K 4535
EIF3L 3545
EIF3F 3217
RPS15A 3120
EIF4A1 2463
RPS12 2257
EIF2S1 1847
PABPC1 1667
RPS15 -220
EIF2S2 -941
FAU -1469
EIF3H -1690
EIF3A -3383
EIF3M -3931


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    parallel  stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.3                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.4.4                                      
##  [4] reshape2_1.4.4                                     
##  [5] beeswarm_0.4.0                                     
##  [6] gplots_3.1.3                                       
##  [7] gtools_3.9.4                                       
##  [8] tibble_3.2.1                                       
##  [9] dplyr_1.1.3                                        
## [10] echarts4r_0.4.5                                    
## [11] eulerr_7.0.0                                       
## [12] kableExtra_1.3.4                                   
## [13] data.table_1.14.8                                  
## [14] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [15] minfi_1.48.0                                       
## [16] bumphunter_1.44.0                                  
## [17] locfit_1.5-9.8                                     
## [18] iterators_1.0.14                                   
## [19] foreach_1.5.2                                      
## [20] Biostrings_2.70.1                                  
## [21] XVector_0.42.0                                     
## [22] SummarizedExperiment_1.32.0                        
## [23] Biobase_2.62.0                                     
## [24] MatrixGenerics_1.14.0                              
## [25] matrixStats_1.1.0                                  
## [26] GenomicRanges_1.54.1                               
## [27] GenomeInfoDb_1.38.1                                
## [28] IRanges_2.36.0                                     
## [29] S4Vectors_0.40.1                                   
## [30] BiocGenerics_0.48.1                                
## [31] mitch_1.14.0                                       
## [32] limma_3.58.1                                       
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.3.2             later_1.3.1              
##   [3] BiocIO_1.12.0             bitops_1.0-7             
##   [5] filelock_1.0.2            preprocessCore_1.64.0    
##   [7] XML_3.99-0.15             lifecycle_1.0.4          
##   [9] lattice_0.22-5            MASS_7.3-60              
##  [11] base64_2.0.1              scrime_1.3.5             
##  [13] magrittr_2.0.3            sass_0.4.7               
##  [15] rmarkdown_2.25            jquerylib_0.1.4          
##  [17] yaml_2.3.7                httpuv_1.6.12            
##  [19] doRNG_1.8.6               askpass_1.2.0            
##  [21] DBI_1.1.3                 RColorBrewer_1.1-3       
##  [23] abind_1.4-5               zlibbioc_1.48.0          
##  [25] rvest_1.0.3               quadprog_1.5-8           
##  [27] purrr_1.0.2               RCurl_1.98-1.13          
##  [29] rappdirs_0.3.3            GenomeInfoDbData_1.2.11  
##  [31] genefilter_1.84.0         annotate_1.80.0          
##  [33] svglite_2.1.2             DelayedMatrixStats_1.24.0
##  [35] codetools_0.2-19          DelayedArray_0.28.0      
##  [37] xml2_1.3.5                tidyselect_1.2.0         
##  [39] beanplot_1.3.1            BiocFileCache_2.10.1     
##  [41] illuminaio_0.44.0         webshot_0.5.5            
##  [43] GenomicAlignments_1.38.0  jsonlite_1.8.7           
##  [45] multtest_2.58.0           ellipsis_0.3.2           
##  [47] survival_3.5-7            systemfonts_1.0.5        
##  [49] tools_4.3.2               progress_1.2.2           
##  [51] Rcpp_1.0.11               glue_1.6.2               
##  [53] gridExtra_2.3             SparseArray_1.2.2        
##  [55] xfun_0.41                 HDF5Array_1.30.0         
##  [57] withr_2.5.2               fastmap_1.1.1            
##  [59] rhdf5filters_1.14.1       fansi_1.0.5              
##  [61] openssl_2.1.1             caTools_1.18.2           
##  [63] digest_0.6.33             R6_2.5.1                 
##  [65] mime_0.12                 colorspace_2.1-0         
##  [67] biomaRt_2.58.0            RSQLite_2.3.3            
##  [69] tidyr_1.3.0               utf8_1.2.4               
##  [71] generics_0.1.3            rtracklayer_1.62.0       
##  [73] prettyunits_1.2.0         httr_1.4.7               
##  [75] htmlwidgets_1.6.2         S4Arrays_1.2.0           
##  [77] pkgconfig_2.0.3           gtable_0.3.4             
##  [79] blob_1.2.4                siggenes_1.76.0          
##  [81] htmltools_0.5.7           scales_1.2.1             
##  [83] png_0.1-8                 knitr_1.45               
##  [85] rstudioapi_0.15.0         tzdb_0.4.0               
##  [87] rjson_0.2.21              nlme_3.1-163             
##  [89] curl_5.1.0                cachem_1.0.8             
##  [91] rhdf5_2.46.0              stringr_1.5.0            
##  [93] KernSmooth_2.23-22        AnnotationDbi_1.64.1     
##  [95] restfulr_0.0.15           GEOquery_2.70.0          
##  [97] pillar_1.9.0              grid_4.3.2               
##  [99] reshape_0.8.9             vctrs_0.6.4              
## [101] promises_1.2.1            dbplyr_2.4.0             
## [103] xtable_1.8-4              evaluate_0.23            
## [105] readr_2.1.4               GenomicFeatures_1.54.1   
## [107] cli_3.6.1                 compiler_4.3.2           
## [109] Rsamtools_2.18.0          rlang_1.1.2              
## [111] crayon_1.5.2              rngtools_1.5.2           
## [113] nor1mix_1.3-0             mclust_6.0.0             
## [115] plyr_1.8.9                stringi_1.7.12           
## [117] viridisLite_0.4.2         BiocParallel_1.36.0      
## [119] munsell_0.5.0             Matrix_1.6-2             
## [121] hms_1.1.3                 sparseMatrixStats_1.14.0 
## [123] bit64_4.0.5               Rhdf5lib_1.24.0          
## [125] KEGGREST_1.42.0           statmod_1.5.0            
## [127] shiny_1.7.5.1             highr_0.10               
## [129] memoise_2.0.1             bslib_0.5.1              
## [131] bit_4.0.5

END of report