Mitch Report

date generated: 2023-01-24

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                  bl          gu
## A1BG     -0.1688419 -0.06961266
## A1BG-AS1  0.2601311 -0.65669533
## A1CF     -0.5671655 -0.29613953
## A2BP1    -0.2903348 -0.21182307
## A2LD1    -0.2300991 -0.39584954
## A2M      -1.1598597 -0.31302236

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	25716
duplicated_genes_present	0
num_profile_genes_in_sets	10215
num_profile_genes_not_in_sets	15501
profile_pearson_correl	0.1922
profile_spearman_correl	0.22567

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2584
num_genesets_excluded	1038
num_genesets_included	1546

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 334

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.bl	s.gu	p.bl	p.gu
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	1.33e-10	4.66e-09	0.689	-0.526	-0.445	1.29e-08	1.49e-06
Eicosanoids	12	8.41e-05	7.70e-04	0.669	0.650	-0.159	9.59e-05	3.40e-01
Scavenging of heme from plasma	12	2.05e-03	1.33e-02	0.637	-0.553	-0.316	9.15e-04	5.82e-02
Prednisone ADME	10	6.78e-03	3.57e-02	0.630	-0.333	-0.534	6.84e-02	3.43e-03
Glucuronidation	25	8.10e-06	9.14e-05	0.617	-0.485	-0.381	2.72e-05	9.62e-04
SARS-CoV-1 modulates host translation machinery	34	1.07e-07	2.22e-06	0.609	0.529	0.301	9.22e-08	2.35e-03
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	1.59e-07	3.03e-06	0.555	-0.448	-0.329	7.04e-07	2.71e-04
Peptide chain elongation	84	1.58e-14	1.16e-12	0.548	0.468	0.285	1.16e-13	6.49e-06
Eukaryotic Translation Elongation	88	7.71e-15	6.62e-13	0.541	0.464	0.278	5.12e-14	6.66e-06
TICAM1-dependent activation of IRF3/IRF7	12	1.42e-02	6.18e-02	0.538	0.368	0.393	2.74e-02	1.84e-02
Aspirin ADME	44	1.76e-07	3.28e-06	0.538	-0.372	-0.388	1.92e-05	8.43e-06
Eukaryotic Translation Termination	87	5.27e-14	3.54e-12	0.526	0.456	0.262	1.83e-13	2.34e-05
Selenocysteine synthesis	87	5.84e-14	3.61e-12	0.525	0.455	0.262	2.01e-13	2.42e-05
Viral mRNA Translation	84	3.14e-13	1.67e-11	0.522	0.445	0.272	1.74e-12	1.61e-05
PINK1-PRKN Mediated Mitophagy	21	1.06e-03	7.80e-03	0.516	0.348	0.382	5.81e-03	2.46e-03
Pexophagy	11	2.64e-02	1.00e-01	0.516	0.420	0.299	1.59e-02	8.60e-02
TICAM1,TRAF6-dependent induction of TAK1 complex	10	3.87e-02	1.34e-01	0.515	0.348	0.380	5.70e-02	3.72e-02
SCF(Skp2)-mediated degradation of p27/p21	58	9.06e-09	2.50e-07	0.511	0.355	0.368	2.91e-06	1.25e-06
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	5.58e-14	3.60e-12	0.504	0.435	0.254	2.25e-13	1.89e-05
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	6.26e-13	2.85e-11	0.501	0.426	0.263	3.56e-12	1.75e-05
Digestion	18	3.38e-03	2.03e-02	0.498	-0.241	-0.435	7.67e-02	1.39e-03
cGMP effects	15	6.92e-03	3.58e-02	0.497	-0.175	-0.465	2.41e-01	1.83e-03
Apoptotic cleavage of cell adhesion proteins	11	2.62e-02	1.00e-01	0.493	-0.467	-0.160	7.37e-03	3.58e-01
Autodegradation of Cdh1 by Cdh1:APC/C	62	1.34e-08	3.45e-07	0.489	0.321	0.368	1.23e-05	5.20e-07
Formation of a pool of free 40S subunits	94	3.80e-13	1.84e-11	0.488	0.428	0.234	6.78e-13	8.80e-05
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.72e-02	7.26e-02	0.485	0.294	0.385	5.69e-02	1.26e-02
Expression and translocation of olfactory receptors	356	1.04e-44	1.61e-41	0.483	-0.301	-0.377	1.26e-22	1.49e-34
Sensory perception of taste	47	1.51e-06	2.20e-05	0.483	-0.356	-0.326	2.34e-05	1.12e-04
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	16	1.23e-03	8.68e-03	0.482	-0.456	0.157	1.58e-03	2.76e-01
TICAM1, RIP1-mediated IKK complex recruitment	18	5.99e-03	3.27e-02	0.482	0.335	0.347	1.38e-02	1.09e-02
Mitophagy	27	4.87e-04	3.84e-03	0.480	0.312	0.364	4.95e-03	1.05e-03
Activation of the TFAP2 (AP-2) family of transcription factors	11	4.53e-02	1.50e-01	0.479	0.351	0.326	4.37e-02	6.08e-02
Senescence-Associated Secretory Phenotype (SASP)	53	2.63e-07	4.72e-06	0.478	0.265	0.398	8.29e-04	5.31e-07
APC/C:Cdc20 mediated degradation of Cyclin B	24	1.14e-03	8.25e-03	0.478	0.286	0.383	1.54e-02	1.17e-03
Olfactory Signaling Pathway	363	3.44e-44	1.77e-41	0.475	-0.293	-0.374	7.56e-22	1.25e-34
SARS-CoV-2 modulates host translation machinery	46	2.34e-06	3.12e-05	0.474	0.400	0.253	2.62e-06	2.95e-03
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	1.25e-06	1.86e-05	0.471	0.321	0.345	8.54e-05	2.40e-05
The role of GTSE1 in G2/M progression after G2 checkpoint	58	1.45e-07	2.81e-06	0.471	0.356	0.308	2.66e-06	5.07e-05
SUMOylation of immune response proteins	10	6.51e-02	1.95e-01	0.470	0.286	0.373	1.17e-01	4.10e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	104	2.76e-13	1.52e-11	0.467	0.410	0.223	4.97e-13	8.24e-05
Hh mutants are degraded by ERAD	54	5.85e-07	9.32e-06	0.466	0.349	0.309	9.11e-06	8.65e-05
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	7.67e-07	1.17e-05	0.466	0.353	0.304	8.89e-06	1.28e-04
Mitochondrial iron-sulfur cluster biogenesis	12	4.18e-02	1.42e-01	0.464	0.305	0.350	6.75e-02	3.56e-02
Ubiquitin-dependent degradation of Cyclin D	50	1.92e-06	2.72e-05	0.462	0.363	0.287	9.15e-06	4.47e-04
SRP-dependent cotranslational protein targeting to membrane	105	6.66e-13	2.94e-11	0.462	0.390	0.247	5.11e-12	1.17e-05
Vpu mediated degradation of CD4	50	2.21e-06	3.02e-05	0.461	0.344	0.307	2.56e-05	1.70e-04
Activation of RAC1	11	4.50e-02	1.50e-01	0.461	-0.425	-0.178	1.46e-02	3.06e-01
Autodegradation of the E3 ubiquitin ligase COP1	50	1.99e-06	2.78e-05	0.461	0.367	0.279	6.93e-06	6.54e-04
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	3.19e-05	3.18e-04	0.460	0.152	0.435	1.14e-01	6.38e-06
Formation of the ternary complex, and subsequently, the 43S complex	46	3.43e-06	4.31e-05	0.458	0.414	0.195	1.14e-06	2.21e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.bl	s.gu	p.bl	p.gu
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	1.33e-10	4.66e-09	0.68900	-5.26e-01	-0.445000	1.29e-08	1.49e-06
Eicosanoids	12	8.41e-05	7.70e-04	0.66900	6.50e-01	-0.159000	9.59e-05	3.40e-01
Scavenging of heme from plasma	12	2.05e-03	1.33e-02	0.63700	-5.53e-01	-0.316000	9.15e-04	5.82e-02
Prednisone ADME	10	6.78e-03	3.57e-02	0.63000	-3.33e-01	-0.534000	6.84e-02	3.43e-03
Glucuronidation	25	8.10e-06	9.14e-05	0.61700	-4.85e-01	-0.381000	2.72e-05	9.62e-04
SARS-CoV-1 modulates host translation machinery	34	1.07e-07	2.22e-06	0.60900	5.29e-01	0.301000	9.22e-08	2.35e-03
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	1.59e-07	3.03e-06	0.55500	-4.48e-01	-0.329000	7.04e-07	2.71e-04
Peptide chain elongation	84	1.58e-14	1.16e-12	0.54800	4.68e-01	0.285000	1.16e-13	6.49e-06
Eukaryotic Translation Elongation	88	7.71e-15	6.62e-13	0.54100	4.64e-01	0.278000	5.12e-14	6.66e-06
TICAM1-dependent activation of IRF3/IRF7	12	1.42e-02	6.18e-02	0.53800	3.68e-01	0.393000	2.74e-02	1.84e-02
Aspirin ADME	44	1.76e-07	3.28e-06	0.53800	-3.72e-01	-0.388000	1.92e-05	8.43e-06
Eukaryotic Translation Termination	87	5.27e-14	3.54e-12	0.52600	4.56e-01	0.262000	1.83e-13	2.34e-05
Selenocysteine synthesis	87	5.84e-14	3.61e-12	0.52500	4.55e-01	0.262000	2.01e-13	2.42e-05
Viral mRNA Translation	84	3.14e-13	1.67e-11	0.52200	4.45e-01	0.272000	1.74e-12	1.61e-05
PINK1-PRKN Mediated Mitophagy	21	1.06e-03	7.80e-03	0.51600	3.48e-01	0.382000	5.81e-03	2.46e-03
Pexophagy	11	2.64e-02	1.00e-01	0.51600	4.20e-01	0.299000	1.59e-02	8.60e-02
TICAM1,TRAF6-dependent induction of TAK1 complex	10	3.87e-02	1.34e-01	0.51500	3.48e-01	0.380000	5.70e-02	3.72e-02
SCF(Skp2)-mediated degradation of p27/p21	58	9.06e-09	2.50e-07	0.51100	3.55e-01	0.368000	2.91e-06	1.25e-06
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	5.58e-14	3.60e-12	0.50400	4.35e-01	0.254000	2.25e-13	1.89e-05
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	6.26e-13	2.85e-11	0.50100	4.26e-01	0.263000	3.56e-12	1.75e-05
Digestion	18	3.38e-03	2.03e-02	0.49800	-2.41e-01	-0.435000	7.67e-02	1.39e-03
cGMP effects	15	6.92e-03	3.58e-02	0.49700	-1.75e-01	-0.465000	2.41e-01	1.83e-03
Apoptotic cleavage of cell adhesion proteins	11	2.62e-02	1.00e-01	0.49300	-4.67e-01	-0.160000	7.37e-03	3.58e-01
Autodegradation of Cdh1 by Cdh1:APC/C	62	1.34e-08	3.45e-07	0.48900	3.21e-01	0.368000	1.23e-05	5.20e-07
Formation of a pool of free 40S subunits	94	3.80e-13	1.84e-11	0.48800	4.28e-01	0.234000	6.78e-13	8.80e-05
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.72e-02	7.26e-02	0.48500	2.94e-01	0.385000	5.69e-02	1.26e-02
Expression and translocation of olfactory receptors	356	1.04e-44	1.61e-41	0.48300	-3.01e-01	-0.377000	1.26e-22	1.49e-34
Sensory perception of taste	47	1.51e-06	2.20e-05	0.48300	-3.56e-01	-0.326000	2.34e-05	1.12e-04
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	16	1.23e-03	8.68e-03	0.48200	-4.56e-01	0.157000	1.58e-03	2.76e-01
TICAM1, RIP1-mediated IKK complex recruitment	18	5.99e-03	3.27e-02	0.48200	3.35e-01	0.347000	1.38e-02	1.09e-02
Mitophagy	27	4.87e-04	3.84e-03	0.48000	3.12e-01	0.364000	4.95e-03	1.05e-03
Activation of the TFAP2 (AP-2) family of transcription factors	11	4.53e-02	1.50e-01	0.47900	3.51e-01	0.326000	4.37e-02	6.08e-02
Senescence-Associated Secretory Phenotype (SASP)	53	2.63e-07	4.72e-06	0.47800	2.65e-01	0.398000	8.29e-04	5.31e-07
APC/C:Cdc20 mediated degradation of Cyclin B	24	1.14e-03	8.25e-03	0.47800	2.86e-01	0.383000	1.54e-02	1.17e-03
Olfactory Signaling Pathway	363	3.44e-44	1.77e-41	0.47500	-2.93e-01	-0.374000	7.56e-22	1.25e-34
SARS-CoV-2 modulates host translation machinery	46	2.34e-06	3.12e-05	0.47400	4.00e-01	0.253000	2.62e-06	2.95e-03
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	1.25e-06	1.86e-05	0.47100	3.21e-01	0.345000	8.54e-05	2.40e-05
The role of GTSE1 in G2/M progression after G2 checkpoint	58	1.45e-07	2.81e-06	0.47100	3.56e-01	0.308000	2.66e-06	5.07e-05
SUMOylation of immune response proteins	10	6.51e-02	1.95e-01	0.47000	2.86e-01	0.373000	1.17e-01	4.10e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	104	2.76e-13	1.52e-11	0.46700	4.10e-01	0.223000	4.97e-13	8.24e-05
Hh mutants are degraded by ERAD	54	5.85e-07	9.32e-06	0.46600	3.49e-01	0.309000	9.11e-06	8.65e-05
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	7.67e-07	1.17e-05	0.46600	3.53e-01	0.304000	8.89e-06	1.28e-04
Mitochondrial iron-sulfur cluster biogenesis	12	4.18e-02	1.42e-01	0.46400	3.05e-01	0.350000	6.75e-02	3.56e-02
Ubiquitin-dependent degradation of Cyclin D	50	1.92e-06	2.72e-05	0.46200	3.63e-01	0.287000	9.15e-06	4.47e-04
SRP-dependent cotranslational protein targeting to membrane	105	6.66e-13	2.94e-11	0.46200	3.90e-01	0.247000	5.11e-12	1.17e-05
Vpu mediated degradation of CD4	50	2.21e-06	3.02e-05	0.46100	3.44e-01	0.307000	2.56e-05	1.70e-04
Activation of RAC1	11	4.50e-02	1.50e-01	0.46100	-4.25e-01	-0.178000	1.46e-02	3.06e-01
Autodegradation of the E3 ubiquitin ligase COP1	50	1.99e-06	2.78e-05	0.46100	3.67e-01	0.279000	6.93e-06	6.54e-04
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	3.19e-05	3.18e-04	0.46000	1.52e-01	0.435000	1.14e-01	6.38e-06
Formation of the ternary complex, and subsequently, the 43S complex	46	3.43e-06	4.31e-05	0.45800	4.14e-01	0.195000	1.14e-06	2.21e-02
L13a-mediated translational silencing of Ceruloplasmin expression	103	1.06e-12	4.42e-11	0.45800	4.02e-01	0.220000	1.74e-12	1.17e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	2.70e-06	3.51e-05	0.45800	3.41e-01	0.305000	2.93e-05	1.93e-04
p53-Independent DNA Damage Response	50	2.70e-06	3.51e-05	0.45800	3.41e-01	0.305000	2.93e-05	1.93e-04
p53-Independent G1/S DNA damage checkpoint	50	2.70e-06	3.51e-05	0.45800	3.41e-01	0.305000	2.93e-05	1.93e-04
Selenoamino acid metabolism	103	1.26e-12	5.13e-11	0.45800	3.98e-01	0.226000	2.92e-12	7.18e-05
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	6.84e-03	3.57e-02	0.45600	1.13e-01	0.442000	4.20e-01	1.60e-03
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	6.84e-03	3.57e-02	0.45600	1.13e-01	0.442000	4.20e-01	1.60e-03
Cap-dependent Translation Initiation	111	1.64e-13	9.39e-12	0.45600	3.99e-01	0.221000	3.54e-13	5.74e-05
Eukaryotic Translation Initiation	111	1.64e-13	9.39e-12	0.45600	3.99e-01	0.221000	3.54e-13	5.74e-05
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	1.27e-08	3.40e-07	0.45500	3.25e-01	0.318000	1.88e-06	2.97e-06
APC/C:Cdc20 mediated degradation of Securin	66	5.89e-08	1.28e-06	0.45400	3.33e-01	0.309000	2.84e-06	1.42e-05
Regulation of RUNX3 expression and activity	53	2.02e-06	2.79e-05	0.45000	3.24e-01	0.312000	4.51e-05	8.31e-05
SCF-beta-TrCP mediated degradation of Emi1	53	2.23e-06	3.02e-05	0.44800	3.32e-01	0.301000	2.93e-05	1.49e-04
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	7.21e-06	8.38e-05	0.44800	3.47e-01	0.283000	3.09e-05	7.02e-04
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	2.29e-06	3.08e-05	0.44700	3.43e-01	0.286000	1.55e-05	3.10e-04
NF-kB is activated and signals survival	12	5.33e-02	1.69e-01	0.44600	3.39e-01	0.290000	4.18e-02	8.24e-02
Diseases of mitotic cell cycle	37	5.34e-05	5.12e-04	0.44500	1.55e-01	0.417000	1.02e-01	1.16e-05
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	108	2.58e-12	9.72e-11	0.44400	3.74e-01	0.239000	1.78e-11	1.72e-05
Nonsense-Mediated Decay (NMD)	108	2.58e-12	9.72e-11	0.44400	3.74e-01	0.239000	1.78e-11	1.72e-05
Stabilization of p53	55	1.67e-06	2.40e-05	0.44400	3.40e-01	0.286000	1.32e-05	2.42e-04
RIPK1-mediated regulated necrosis	27	1.37e-03	9.48e-03	0.44300	3.63e-01	0.254000	1.09e-03	2.24e-02
Regulation of necroptotic cell death	27	1.37e-03	9.48e-03	0.44300	3.63e-01	0.254000	1.09e-03	2.24e-02
MET activates RAS signaling	11	1.73e-02	7.28e-02	0.44300	-3.88e-01	0.214000	2.59e-02	2.20e-01
Major pathway of rRNA processing in the nucleolus and cytosol	171	7.00e-19	9.84e-17	0.44300	3.70e-01	0.243000	6.15e-17	4.13e-08
Negative regulation of NOTCH4 signaling	52	4.11e-06	5.08e-05	0.44200	3.15e-01	0.310000	8.64e-05	1.08e-04
Phosphorylation of the APC/C	20	6.56e-03	3.50e-02	0.44100	1.98e-01	0.394000	1.24e-01	2.30e-03
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	5.73e-03	3.15e-02	0.44000	1.65e-01	0.408000	2.02e-01	1.57e-03
p53-Dependent G1 DNA Damage Response	64	2.84e-07	4.88e-06	0.43900	3.09e-01	0.312000	1.94e-05	1.53e-05
p53-Dependent G1/S DNA damage checkpoint	64	2.84e-07	4.88e-06	0.43900	3.09e-01	0.312000	1.94e-05	1.53e-05
CDK-mediated phosphorylation and removal of Cdc6	71	5.79e-08	1.28e-06	0.43800	2.88e-01	0.330000	2.66e-05	1.54e-06
Cross-presentation of soluble exogenous antigens (endosomes)	46	1.90e-05	1.96e-04	0.43500	3.61e-01	0.243000	2.24e-05	4.40e-03
rRNA processing in the nucleus and cytosol	180	5.58e-19	8.63e-17	0.43400	3.55e-01	0.250000	1.96e-16	6.69e-09
Hh mutants abrogate ligand secretion	57	1.94e-06	2.72e-05	0.43400	3.23e-01	0.291000	2.49e-05	1.46e-04
Digestion and absorption	23	4.06e-03	2.37e-02	0.43400	-2.15e-01	-0.377000	7.42e-02	1.76e-03
Fatty acids	15	7.35e-03	3.74e-02	0.43300	4.19e-01	-0.107000	4.94e-03	4.73e-01
Defective CFTR causes cystic fibrosis	59	1.43e-06	2.11e-05	0.42900	3.45e-01	0.255000	4.47e-06	6.92e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	1.19e-07	2.42e-06	0.42900	3.05e-01	0.301000	8.48e-06	1.15e-05
Vif-mediated degradation of APOBEC3G	50	1.41e-05	1.48e-04	0.42600	3.30e-01	0.270000	5.47e-05	9.38e-04
G1/S DNA Damage Checkpoints	66	4.32e-07	7.02e-06	0.42600	2.92e-01	0.311000	4.10e-05	1.26e-05
Unwinding of DNA	12	6.71e-02	1.98e-01	0.42600	2.53e-01	0.343000	1.30e-01	3.95e-02
Influenza Viral RNA Transcription and Replication	129	3.33e-13	1.72e-11	0.42500	3.37e-01	0.260000	3.69e-11	3.50e-07
Processing and activation of SUMO	10	9.27e-02	2.45e-01	0.42100	1.50e-01	0.393000	4.12e-01	3.13e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	3.14e-02	1.15e-01	0.42000	2.86e-01	0.308000	4.78e-02	3.28e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	1.79e-07	3.30e-06	0.42000	3.02e-01	0.293000	9.61e-06	1.72e-05
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	1.00e-07	2.09e-06	0.42000	2.95e-01	0.298000	1.01e-05	7.76e-06
APC/C:Cdc20 mediated degradation of mitotic proteins	74	1.33e-07	2.65e-06	0.41900	2.95e-01	0.297000	1.16e-05	9.75e-06
Dectin-1 mediated noncanonical NF-kB signaling	60	2.79e-06	3.53e-05	0.41800	3.06e-01	0.284000	4.17e-05	1.38e-04
Regulation of APC/C activators between G1/S and early anaphase	79	4.88e-08	1.12e-06	0.41700	2.71e-01	0.317000	3.18e-05	1.07e-06
Interaction With Cumulus Cells And The Zona Pellucida	11	4.64e-02	1.53e-01	0.41700	1.50e-02	-0.417000	9.31e-01	1.67e-02
NRIF signals cell death from the nucleus	16	3.30e-02	1.20e-01	0.41700	3.18e-01	0.269000	2.74e-02	6.28e-02
rRNA processing	186	6.40e-18	7.61e-16	0.41500	3.36e-01	0.244000	2.63e-15	8.62e-09
Regulation of expression of SLITs and ROBOs	159	2.22e-15	2.01e-13	0.41400	3.36e-01	0.243000	2.70e-13	1.16e-07
Early Phase of HIV Life Cycle	14	4.20e-02	1.42e-01	0.41400	1.64e-01	0.380000	2.89e-01	1.37e-02
Degradation of DVL	55	9.93e-06	1.08e-04	0.41400	3.03e-01	0.282000	1.01e-04	2.95e-04
Respiratory electron transport	90	3.66e-09	1.11e-07	0.41400	2.14e-01	0.354000	4.41e-04	6.34e-09
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	1.23e-01	2.99e-01	0.41400	3.04e-01	0.281000	9.64e-02	1.24e-01
Ribosomal scanning and start codon recognition	53	7.66e-06	8.71e-05	0.41300	3.73e-01	0.178000	2.60e-06	2.51e-02
Activation of the phototransduction cascade	11	1.00e-01	2.60e-01	0.41300	-2.75e-01	-0.308000	1.14e-01	7.69e-02
NIK–>noncanonical NF-kB signaling	57	7.20e-06	8.38e-05	0.41200	3.01e-01	0.281000	8.22e-05	2.39e-04
GLI3 is processed to GLI3R by the proteasome	58	6.55e-06	7.79e-05	0.41000	3.10e-01	0.269000	4.51e-05	4.02e-04
APC/C-mediated degradation of cell cycle proteins	86	2.36e-08	5.69e-07	0.40900	2.69e-01	0.307000	1.58e-05	8.26e-07
Regulation of mitotic cell cycle	86	2.36e-08	5.69e-07	0.40900	2.69e-01	0.307000	1.58e-05	8.26e-07
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	54	9.21e-06	1.02e-04	0.40600	3.67e-01	0.173000	3.02e-06	2.78e-02
Purine ribonucleoside monophosphate biosynthesis	11	6.57e-02	1.96e-01	0.40600	4.34e-02	0.403000	8.03e-01	2.05e-02
Degradation of GLI2 by the proteasome	58	8.19e-06	9.17e-05	0.40600	3.12e-01	0.259000	3.87e-05	6.50e-04
Regulation of ornithine decarboxylase (ODC)	49	6.30e-05	5.90e-04	0.40200	2.89e-01	0.280000	4.70e-04	7.06e-04
Assembly of the pre-replicative complex	82	7.51e-08	1.61e-06	0.40100	2.24e-01	0.332000	4.60e-04	1.94e-07
Nitric oxide stimulates guanylate cyclase	22	8.11e-03	4.03e-02	0.40000	-1.26e-01	-0.380000	3.05e-01	2.04e-03
Translation initiation complex formation	53	1.52e-05	1.59e-04	0.40000	3.63e-01	0.168000	4.70e-06	3.46e-02
Degradation of GLI1 by the proteasome	58	1.22e-05	1.30e-04	0.40000	2.91e-01	0.274000	1.25e-04	3.11e-04
Defective C1GALT1C1 causes TNPS	18	2.96e-02	1.10e-01	0.39900	-2.56e-01	-0.306000	6.05e-02	2.44e-02
mRNA Splicing - Minor Pathway	51	3.37e-05	3.34e-04	0.39800	3.47e-01	0.195000	1.77e-05	1.61e-02
Assembly of the ORC complex at the origin of replication	10	5.18e-02	1.66e-01	0.39700	-3.49e-01	0.189000	5.60e-02	3.00e-01
Cytosolic iron-sulfur cluster assembly	10	1.44e-01	3.31e-01	0.39700	2.52e-01	0.307000	1.68e-01	9.30e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	1.56e-02	6.69e-02	0.39700	1.55e-01	0.365000	2.29e-01	4.72e-03
Cyclin E associated events during G1/S transition	81	1.75e-07	3.28e-06	0.39600	2.54e-01	0.303000	7.59e-05	2.32e-06
Response of EIF2AK1 (HRI) to heme deficiency	14	6.64e-02	1.97e-01	0.39500	3.19e-01	0.234000	3.88e-02	1.30e-01
Influenza Infection	148	5.50e-13	2.58e-11	0.39500	3.01e-01	0.255000	2.38e-10	8.14e-08
APC-Cdc20 mediated degradation of Nek2A	26	6.65e-03	3.53e-02	0.39400	2.30e-01	0.320000	4.19e-02	4.76e-03
Josephin domain DUBs	11	1.18e-01	2.93e-01	0.39400	2.15e-01	0.330000	2.17e-01	5.83e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	95	7.15e-09	2.01e-07	0.39300	1.90e-01	0.345000	1.38e-03	6.27e-09
Cyclin A:Cdk2-associated events at S phase entry	83	1.44e-07	2.81e-06	0.39300	2.52e-01	0.303000	7.40e-05	1.87e-06
Suppression of phagosomal maturation	13	8.79e-02	2.36e-01	0.39100	2.80e-01	0.273000	8.00e-02	8.89e-02
Lysosome Vesicle Biogenesis	33	3.69e-04	2.97e-03	0.39000	1.32e-03	0.390000	9.90e-01	1.06e-04
TNFR1-induced proapoptotic signaling	13	8.81e-02	2.36e-01	0.38900	2.40e-01	0.306000	1.33e-01	5.60e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	16	2.13e-02	8.52e-02	0.38900	-5.39e-03	0.389000	9.70e-01	7.06e-03
Defective GALNT12 causes CRCS1	18	3.42e-02	1.22e-01	0.38900	-2.30e-01	-0.314000	9.17e-02	2.11e-02
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	6.50e-03	3.48e-02	0.38700	2.24e-01	0.316000	4.41e-02	4.45e-03
Switching of origins to a post-replicative state	90	4.93e-08	1.12e-06	0.38700	2.14e-01	0.322000	4.37e-04	1.24e-07
ERKs are inactivated	13	8.36e-02	2.30e-01	0.38700	1.89e-01	0.337000	2.37e-01	3.52e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	3.62e-02	1.27e-01	0.38700	2.40e-01	0.303000	7.83e-02	2.58e-02
Asymmetric localization of PCP proteins	62	1.25e-05	1.32e-04	0.38600	2.87e-01	0.258000	9.34e-05	4.37e-04
Heme degradation	16	3.61e-02	1.27e-01	0.38400	-9.74e-02	-0.372000	5.00e-01	1.00e-02
Pausing and recovery of Tat-mediated HIV elongation	27	7.62e-03	3.84e-02	0.38400	2.70e-01	0.274000	1.53e-02	1.37e-02
Tat-mediated HIV elongation arrest and recovery	27	7.62e-03	3.84e-02	0.38400	2.70e-01	0.274000	1.53e-02	1.37e-02
Glucocorticoid biosynthesis	10	1.20e-01	2.95e-01	0.38300	-7.31e-02	-0.376000	6.89e-01	3.95e-02
Transcriptional regulation of granulopoiesis	31	5.94e-04	4.61e-03	0.38200	-3.24e-02	0.381000	7.55e-01	2.40e-04
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	62	1.55e-05	1.61e-04	0.38200	2.91e-01	0.247000	7.37e-05	7.64e-04
Sensory Perception	567	2.25e-44	1.74e-41	0.38200	-2.27e-01	-0.307000	2.22e-20	4.38e-36
DNA Replication Pre-Initiation	97	2.78e-08	6.51e-07	0.38100	2.27e-01	0.306000	1.12e-04	1.84e-07
p75NTR signals via NF-kB	15	6.67e-02	1.98e-01	0.38100	3.11e-01	0.219000	3.68e-02	1.41e-01
Regulation of Apoptosis	51	1.17e-04	1.04e-03	0.38100	2.89e-01	0.247000	3.48e-04	2.27e-03
tRNA processing in the nucleus	55	5.57e-05	5.29e-04	0.38000	2.28e-01	0.303000	3.42e-03	9.84e-05
mRNA Splicing	184	8.99e-15	7.32e-13	0.37900	2.92e-01	0.242000	8.19e-12	1.44e-08
SUMOylation of transcription factors	20	1.95e-02	7.99e-02	0.37900	1.15e-01	0.361000	3.72e-01	5.22e-03
Translation	262	1.10e-20	2.44e-18	0.37800	3.00e-01	0.231000	6.20e-17	1.12e-10
Class I peroxisomal membrane protein import	19	3.06e-02	1.13e-01	0.37800	3.34e-01	0.178000	1.18e-02	1.79e-01
Defective GALNT3 causes HFTC	18	4.27e-02	1.44e-01	0.37800	-2.49e-01	-0.284000	6.69e-02	3.69e-02
Mitochondrial translation termination	87	2.95e-07	5.01e-06	0.37600	2.86e-01	0.244000	3.98e-06	8.51e-05
Spry regulation of FGF signaling	16	6.11e-02	1.86e-01	0.37400	2.11e-01	0.309000	1.45e-01	3.22e-02
SARS-CoV-1-host interactions	90	2.14e-07	3.90e-06	0.37400	2.60e-01	0.268000	1.95e-05	1.07e-05
Mitochondrial translation	93	1.27e-07	2.56e-06	0.37400	2.82e-01	0.245000	2.61e-06	4.35e-05
Diseases associated with glycosylation precursor biosynthesis	15	7.20e-02	2.08e-01	0.37300	1.96e-01	0.317000	1.89e-01	3.34e-02
NGF-stimulated transcription	39	1.12e-03	8.12e-03	0.37100	1.88e-01	0.320000	4.25e-02	5.47e-04
Mitochondrial translation initiation	87	4.79e-07	7.71e-06	0.36900	2.84e-01	0.236000	4.69e-06	1.38e-04
MyD88 deficiency (TLR2/4)	16	1.57e-02	6.70e-02	0.36900	-2.00e-01	0.310000	1.66e-01	3.15e-02
Cellular response to hypoxia	71	7.36e-06	8.43e-05	0.36900	2.65e-01	0.257000	1.13e-04	1.78e-04
Infection with Mycobacterium tuberculosis	25	1.55e-02	6.67e-02	0.36900	2.68e-01	0.253000	2.02e-02	2.83e-02
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	7.42e-02	2.12e-01	0.36800	1.14e-01	0.350000	4.58e-01	2.33e-02
Condensation of Prometaphase Chromosomes	11	1.26e-01	3.03e-01	0.36700	9.72e-02	0.354000	5.77e-01	4.19e-02
Aspartate and asparagine metabolism	11	1.60e-01	3.53e-01	0.36700	-2.91e-01	-0.224000	9.45e-02	1.98e-01
Metabolism of polyamines	55	1.14e-04	1.02e-03	0.36700	2.74e-01	0.244000	4.30e-04	1.73e-03
Orc1 removal from chromatin	69	1.10e-05	1.18e-04	0.36700	2.31e-01	0.285000	8.83e-04	4.27e-05
Mitochondrial translation elongation	87	6.52e-07	1.03e-05	0.36600	2.77e-01	0.239000	7.85e-06	1.18e-04
Response of Mtb to phagocytosis	22	2.80e-02	1.05e-01	0.36400	2.71e-01	0.244000	2.78e-02	4.80e-02
Signaling by NOTCH4	79	2.72e-06	3.51e-05	0.36400	2.72e-01	0.242000	2.87e-05	1.99e-04
Processing of Capped Intron-Containing Pre-mRNA	232	9.08e-17	1.00e-14	0.36200	2.62e-01	0.250000	5.62e-12	5.46e-11
Degradation of AXIN	53	1.98e-04	1.68e-03	0.36200	2.79e-01	0.231000	4.51e-04	3.58e-03
HIV elongation arrest and recovery	29	9.59e-03	4.49e-02	0.36200	2.63e-01	0.248000	1.40e-02	2.07e-02
Pausing and recovery of HIV elongation	29	9.59e-03	4.49e-02	0.36200	2.63e-01	0.248000	1.40e-02	2.07e-02
SARS-CoV-1 activates/modulates innate immune responses	37	1.62e-03	1.10e-02	0.36200	1.38e-01	0.334000	1.47e-01	4.31e-04
Polo-like kinase mediated events	16	4.98e-02	1.62e-01	0.36200	7.57e-02	0.354000	6.00e-01	1.43e-02
PERK regulates gene expression	32	3.39e-03	2.03e-02	0.36100	3.42e-01	0.115000	8.05e-04	2.61e-01
Dectin-2 family	28	1.05e-02	4.88e-02	0.36100	-3.01e-01	-0.199000	5.84e-03	6.87e-02
ATF4 activates genes in response to endoplasmic reticulum stress	28	7.28e-03	3.73e-02	0.36000	3.40e-01	0.120000	1.87e-03	2.71e-01
Erythrocytes take up carbon dioxide and release oxygen	12	1.47e-01	3.32e-01	0.36000	-2.23e-01	-0.283000	1.82e-01	8.97e-02
O2/CO2 exchange in erythrocytes	12	1.47e-01	3.32e-01	0.36000	-2.23e-01	-0.283000	1.82e-01	8.97e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	3.61e-02	1.27e-01	0.36000	3.59e-02	0.358000	7.97e-01	1.06e-02
TNFR2 non-canonical NF-kB pathway	94	3.45e-07	5.73e-06	0.36000	2.74e-01	0.233000	4.30e-06	9.67e-05
RUNX1 regulates transcription of genes involved in differentiation of HSCs	68	2.02e-05	2.07e-04	0.35900	2.22e-01	0.283000	1.54e-03	5.55e-05
CASP8 activity is inhibited	11	1.47e-01	3.32e-01	0.35900	3.38e-01	0.122000	5.23e-02	4.82e-01
Dimerization of procaspase-8	11	1.47e-01	3.32e-01	0.35900	3.38e-01	0.122000	5.23e-02	4.82e-01
Regulation by c-FLIP	11	1.47e-01	3.32e-01	0.35900	3.38e-01	0.122000	5.23e-02	4.82e-01
Activation of NF-kappaB in B cells	64	4.18e-05	4.09e-04	0.35900	2.70e-01	0.236000	1.87e-04	1.08e-03
mRNA Splicing - Major Pathway	174	1.55e-12	6.16e-11	0.35800	2.73e-01	0.230000	4.71e-10	1.53e-07
RHO GTPases activate KTN1	11	7.71e-02	2.16e-01	0.35700	-1.31e-01	0.332000	4.51e-01	5.62e-02
Hedgehog ligand biogenesis	63	5.42e-05	5.17e-04	0.35700	2.65e-01	0.239000	2.74e-04	1.02e-03
Nuclear events mediated by NFE2L2	76	4.81e-06	5.90e-05	0.35600	1.78e-01	0.309000	7.38e-03	3.19e-06
E2F mediated regulation of DNA replication	20	7.56e-03	3.83e-02	0.35600	-2.32e-01	0.269000	7.23e-02	3.70e-02
Regulation of TNFR1 signaling	37	3.25e-03	1.97e-02	0.35500	2.73e-01	0.227000	4.05e-03	1.68e-02
DNA Damage Recognition in GG-NER	36	4.22e-03	2.42e-02	0.35300	2.44e-01	0.254000	1.12e-02	8.30e-03
Defective Intrinsic Pathway for Apoptosis	25	2.22e-02	8.76e-02	0.35200	2.68e-01	0.229000	2.04e-02	4.75e-02
p75NTR recruits signalling complexes	12	1.61e-01	3.54e-01	0.35200	2.65e-01	0.232000	1.12e-01	1.64e-01
Diseases of programmed cell death	43	1.32e-03	9.26e-03	0.35100	1.96e-01	0.292000	2.63e-02	9.31e-04
Inactivation of APC/C via direct inhibition of the APC/C complex	21	3.58e-02	1.26e-01	0.34900	1.51e-01	0.315000	2.31e-01	1.25e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	3.58e-02	1.26e-01	0.34900	1.51e-01	0.315000	2.31e-01	1.25e-02
DNA Replication	125	6.69e-09	1.91e-07	0.34900	2.02e-01	0.285000	9.90e-05	3.85e-08
Synthesis of DNA	118	1.93e-08	4.90e-07	0.34800	1.94e-01	0.288000	2.65e-04	6.14e-08
Cyclin D associated events in G1	46	9.54e-04	7.13e-03	0.34700	1.86e-01	0.293000	2.90e-02	5.85e-04
G1 Phase	46	9.54e-04	7.13e-03	0.34700	1.86e-01	0.293000	2.90e-02	5.85e-04
Nucleotide biosynthesis	14	7.65e-02	2.15e-01	0.34600	2.40e-02	0.346000	8.76e-01	2.52e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	14	7.07e-02	2.06e-01	0.34600	-7.23e-05	0.346000	1.00e+00	2.49e-02
G1/S Transition	126	6.52e-09	1.90e-07	0.34600	1.87e-01	0.291000	2.95e-04	1.63e-08
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	1.13e-01	2.82e-01	0.34500	-2.42e-01	-0.246000	1.05e-01	9.87e-02
TBC/RABGAPs	42	6.96e-04	5.32e-03	0.34500	5.99e-02	0.340000	5.02e-01	1.40e-04
Thyroxine biosynthesis	10	2.31e-01	4.38e-01	0.34400	-2.77e-01	-0.204000	1.29e-01	2.64e-01
FGFR1c ligand binding and activation	11	2.06e-01	4.02e-01	0.34300	2.42e-01	0.243000	1.65e-01	1.63e-01
Signaling by activated point mutants of FGFR1	11	2.06e-01	4.02e-01	0.34300	2.42e-01	0.243000	1.65e-01	1.63e-01
Regulation of signaling by NODAL	10	1.03e-01	2.65e-01	0.34300	2.47e-01	-0.238000	1.76e-01	1.93e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	3.80e-02	1.32e-01	0.34100	2.47e-01	0.235000	4.00e-02	5.14e-02
Regulation of TP53 Activity through Methylation	18	7.34e-02	2.10e-01	0.34100	2.83e-01	0.190000	3.75e-02	1.64e-01
Recycling of bile acids and salts	18	7.55e-02	2.13e-01	0.34100	-2.05e-01	-0.272000	1.33e-01	4.54e-02
Regulation of TLR by endogenous ligand	17	2.23e-02	8.80e-02	0.34000	-2.56e-01	0.224000	6.73e-02	1.10e-01
UCH proteinases	81	9.44e-06	1.03e-04	0.34000	2.75e-01	0.200000	1.92e-05	1.84e-03
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	1.22e-01	2.98e-01	0.34000	-1.26e-01	0.316000	4.92e-01	8.40e-02
Methylation	14	1.01e-01	2.63e-01	0.33900	3.30e-01	0.078500	3.24e-02	6.11e-01
Mitotic G1 phase and G1/S transition	144	9.61e-10	3.16e-08	0.33800	1.71e-01	0.291000	3.89e-04	1.53e-09
Adherens junctions interactions	26	2.67e-02	1.01e-01	0.33700	-2.14e-01	-0.260000	5.85e-02	2.19e-02
MET activates PTK2 signaling	18	8.25e-02	2.29e-01	0.33600	-2.60e-01	-0.212000	5.59e-02	1.20e-01
Cellular response to starvation	147	1.55e-09	4.78e-08	0.33600	2.61e-01	0.212000	4.86e-08	9.36e-06
Folding of actin by CCT/TriC	10	1.96e-01	3.94e-01	0.33600	3.30e-01	0.063200	7.11e-02	7.29e-01
Interactions of Rev with host cellular proteins	35	4.08e-03	2.37e-02	0.33500	8.53e-02	0.324000	3.82e-01	9.17e-04
Receptor Mediated Mitophagy	10	2.07e-01	4.03e-01	0.33500	8.27e-02	0.324000	6.51e-01	7.58e-02
Constitutive Signaling by Overexpressed ERBB2	10	1.71e-01	3.69e-01	0.33500	8.87e-04	0.335000	9.96e-01	6.70e-02
Lysine catabolism	12	1.54e-01	3.43e-01	0.33400	-8.92e-02	-0.322000	5.93e-01	5.34e-02
Phospholipase C-mediated cascade: FGFR1	16	1.11e-01	2.79e-01	0.33400	2.65e-01	0.203000	6.67e-02	1.60e-01
IKK complex recruitment mediated by RIP1	22	3.41e-02	1.22e-01	0.33400	9.78e-02	0.319000	4.27e-01	9.59e-03
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	2.16e-02	8.62e-02	0.33300	2.07e-01	0.261000	5.82e-02	1.66e-02
Nuclear import of Rev protein	32	7.65e-03	3.84e-02	0.33300	1.01e-01	0.317000	3.22e-01	1.89e-03
Regulation of mRNA stability by proteins that bind AU-rich elements	87	7.31e-06	8.43e-05	0.33300	2.55e-01	0.215000	4.04e-05	5.28e-04
Passive transport by Aquaporins	13	1.45e-01	3.31e-01	0.33300	-1.18e-01	-0.311000	4.60e-01	5.22e-02
FGFR1 ligand binding and activation	15	1.30e-01	3.10e-01	0.33100	2.68e-01	0.194000	7.21e-02	1.94e-01
TNF signaling	45	2.46e-03	1.55e-02	0.33100	2.40e-01	0.228000	5.38e-03	8.26e-03
Complex I biogenesis	49	1.11e-03	8.08e-03	0.32900	1.57e-01	0.290000	5.78e-02	4.47e-04
G1/S-Specific Transcription	28	1.21e-02	5.45e-02	0.32900	5.89e-02	0.324000	5.90e-01	3.00e-03
SUMOylation of SUMOylation proteins	33	8.25e-03	4.07e-02	0.32900	1.16e-01	0.308000	2.50e-01	2.20e-03
Regulation of BACH1 activity	15	1.31e-01	3.12e-01	0.32900	1.80e-01	0.275000	2.27e-01	6.51e-02
Regulation of RAS by GAPs	65	1.89e-04	1.61e-03	0.32800	2.11e-01	0.251000	3.28e-03	4.60e-04
Rev-mediated nuclear export of HIV RNA	33	5.77e-03	3.16e-02	0.32800	5.74e-02	0.323000	5.68e-01	1.34e-03
Translesion Synthesis by POLH	19	7.79e-02	2.17e-01	0.32700	1.75e-01	0.276000	1.86e-01	3.72e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.55e-01	3.45e-01	0.32600	-5.87e-03	0.326000	9.73e-01	6.10e-02
Cleavage of the damaged pyrimidine	16	8.71e-02	2.36e-01	0.32600	6.81e-02	0.319000	6.37e-01	2.72e-02
Depyrimidination	16	8.71e-02	2.36e-01	0.32600	6.81e-02	0.319000	6.37e-01	2.72e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	8.71e-02	2.36e-01	0.32600	6.81e-02	0.319000	6.37e-01	2.72e-02
Metabolism of RNA	639	7.30e-36	2.82e-33	0.32500	2.42e-01	0.217000	1.06e-25	6.89e-21
rRNA modification in the nucleus and cytosol	55	7.39e-04	5.60e-03	0.32500	1.85e-01	0.267000	1.77e-02	6.17e-04
Carnitine metabolism	11	1.08e-01	2.75e-01	0.32500	-1.91e-01	0.263000	2.74e-01	1.31e-01
TRAF3-dependent IRF activation pathway	15	1.06e-01	2.70e-01	0.32500	7.39e-02	0.316000	6.20e-01	3.41e-02
Mitochondrial protein import	54	7.06e-04	5.37e-03	0.32400	1.52e-01	0.286000	5.30e-02	2.80e-04
Formation of apoptosome	10	1.56e-01	3.47e-01	0.32300	3.10e-01	-0.092100	8.95e-02	6.14e-01
Regulation of the apoptosome activity	10	1.56e-01	3.47e-01	0.32300	3.10e-01	-0.092100	8.95e-02	6.14e-01
NEP/NS2 Interacts with the Cellular Export Machinery	30	1.04e-02	4.85e-02	0.32300	5.72e-02	0.318000	5.88e-01	2.55e-03
Signaling by ROBO receptors	203	5.29e-12	1.95e-10	0.32300	2.57e-01	0.195000	2.52e-10	1.69e-06
Androgen biosynthesis	11	2.02e-01	4.01e-01	0.32200	-8.39e-02	-0.311000	6.30e-01	7.41e-02
RNA Polymerase III Transcription Initiation	36	9.11e-03	4.38e-02	0.32200	1.67e-01	0.275000	8.25e-02	4.33e-03
Regulation of innate immune responses to cytosolic DNA	14	1.66e-01	3.61e-01	0.32100	2.64e-01	0.182000	8.68e-02	2.39e-01
Export of Viral Ribonucleoproteins from Nucleus	31	1.16e-02	5.29e-02	0.32100	8.31e-02	0.310000	4.23e-01	2.85e-03
Beta defensins	28	4.11e-03	2.38e-02	0.32000	2.57e-01	-0.190000	1.84e-02	8.23e-02
Metabolism of amine-derived hormones	17	1.17e-01	2.92e-01	0.31900	-2.58e-01	-0.187000	6.57e-02	1.81e-01
Attenuation phase	25	4.48e-02	1.50e-01	0.31900	2.37e-01	0.213000	4.02e-02	6.55e-02
Energy dependent regulation of mTOR by LKB1-AMPK	28	6.21e-03	3.34e-02	0.31600	-1.11e-01	0.296000	3.10e-01	6.62e-03
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	13	1.07e-01	2.72e-01	0.31600	-6.44e-02	0.309000	6.87e-01	5.35e-02
Apoptotic factor-mediated response	17	8.82e-02	2.36e-01	0.31600	3.09e-01	0.065900	2.76e-02	6.38e-01
TRAF6 mediated NF-kB activation	24	3.29e-02	1.20e-01	0.31600	6.79e-02	0.308000	5.65e-01	8.96e-03
FCERI mediated NF-kB activation	74	1.30e-04	1.14e-03	0.31500	2.28e-01	0.216000	6.76e-04	1.28e-03
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	9.66e-02	2.52e-01	0.31500	1.94e-03	0.315000	9.90e-01	3.49e-02
ER-Phagosome pathway	87	2.74e-05	2.75e-04	0.31400	2.04e-01	0.239000	1.01e-03	1.17e-04
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	1.34e-01	3.17e-01	0.31400	1.53e-01	0.274000	2.88e-01	5.80e-02
PCP/CE pathway	90	2.12e-05	2.15e-04	0.31300	2.13e-01	0.229000	4.68e-04	1.71e-04
Bicarbonate transporters	10	2.94e-01	5.14e-01	0.31300	-1.73e-01	-0.260000	3.43e-01	1.54e-01
Purine salvage	12	1.87e-01	3.82e-01	0.31300	6.79e-02	0.305000	6.84e-01	6.72e-02
Free fatty acids regulate insulin secretion	10	1.72e-01	3.69e-01	0.31200	-2.95e-01	0.104000	1.07e-01	5.68e-01
Nuclear Events (kinase and transcription factor activation)	60	4.66e-04	3.69e-03	0.31200	1.28e-01	0.285000	8.60e-02	1.35e-04
XBP1(S) activates chaperone genes	47	1.81e-03	1.19e-02	0.31100	8.70e-02	0.299000	3.02e-01	3.90e-04
Host Interactions of HIV factors	122	4.29e-07	7.02e-06	0.31100	1.79e-01	0.255000	6.56e-04	1.12e-06
Miscellaneous substrates	12	1.10e-01	2.78e-01	0.30900	2.50e-01	-0.182000	1.34e-01	2.74e-01
Negative regulation of FGFR1 signaling	32	2.38e-02	9.29e-02	0.30900	2.15e-01	0.222000	3.49e-02	2.99e-02
KEAP1-NFE2L2 pathway	103	3.57e-06	4.45e-05	0.30900	1.47e-01	0.272000	9.94e-03	1.89e-06
Formation of HIV-1 elongation complex containing HIV-1 Tat	38	1.21e-02	5.45e-02	0.30800	2.13e-01	0.223000	2.31e-02	1.74e-02
HIV Transcription Elongation	38	1.21e-02	5.45e-02	0.30800	2.13e-01	0.223000	2.31e-02	1.74e-02
Tat-mediated elongation of the HIV-1 transcript	38	1.21e-02	5.45e-02	0.30800	2.13e-01	0.223000	2.31e-02	1.74e-02
SUMOylation of ubiquitinylation proteins	37	6.92e-03	3.58e-02	0.30700	6.69e-02	0.300000	4.81e-01	1.61e-03
Keratinization	213	8.76e-12	3.15e-10	0.30700	-1.49e-01	-0.269000	1.85e-04	1.34e-11
FCGR activation	12	1.21e-01	2.97e-01	0.30700	1.42e-01	-0.272000	3.96e-01	1.03e-01
Zinc influx into cells by the SLC39 gene family	10	3.05e-01	5.20e-01	0.30700	1.59e-01	0.262000	3.85e-01	1.51e-01
Selective autophagy	59	1.15e-03	8.25e-03	0.30600	2.11e-01	0.222000	4.97e-03	3.18e-03
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	1.75e-01	3.73e-01	0.30600	1.27e-02	0.306000	9.39e-01	6.65e-02
The NLRP3 inflammasome	16	1.29e-01	3.09e-01	0.30600	9.50e-02	0.290000	5.11e-01	4.43e-02
Transcriptional regulation of testis differentiation	12	1.90e-01	3.85e-01	0.30500	3.98e-02	0.302000	8.11e-01	6.96e-02
Transport of the SLBP Dependant Mature mRNA	34	1.41e-02	6.18e-02	0.30400	1.03e-01	0.286000	2.98e-01	3.83e-03
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	22	8.29e-02	2.29e-01	0.30400	2.22e-01	0.208000	7.10e-02	9.19e-02
Neurodegenerative Diseases	22	8.29e-02	2.29e-01	0.30400	2.22e-01	0.208000	7.10e-02	9.19e-02
Gap junction degradation	10	3.02e-01	5.18e-01	0.30400	-2.72e-01	-0.136000	1.36e-01	4.56e-01
Platelet Adhesion to exposed collagen	13	1.97e-01	3.95e-01	0.30400	-2.86e-01	-0.103000	7.43e-02	5.22e-01
STAT5 activation downstream of FLT3 ITD mutants	10	2.96e-01	5.16e-01	0.30400	1.20e-01	0.279000	5.11e-01	1.27e-01
IRE1alpha activates chaperones	49	2.04e-03	1.33e-02	0.30300	9.06e-02	0.289000	2.73e-01	4.54e-04
Metabolism of non-coding RNA	50	2.23e-03	1.43e-02	0.30300	1.13e-01	0.281000	1.68e-01	5.82e-04
snRNP Assembly	50	2.23e-03	1.43e-02	0.30300	1.13e-01	0.281000	1.68e-01	5.82e-04
Positive epigenetic regulation of rRNA expression	43	6.86e-03	3.57e-02	0.30300	1.54e-01	0.260000	7.96e-02	3.15e-03
Base-Excision Repair, AP Site Formation	18	8.38e-02	2.31e-01	0.30200	2.93e-02	0.301000	8.30e-01	2.73e-02
RNA Polymerase II Pre-transcription Events	73	3.00e-04	2.46e-03	0.30200	2.15e-01	0.212000	1.52e-03	1.72e-03
Hedgehog ‘on’ state	83	1.03e-04	9.28e-04	0.30100	2.10e-01	0.216000	9.50e-04	6.64e-04
Chylomicron remodeling	10	2.06e-01	4.02e-01	0.30100	7.11e-02	-0.293000	6.97e-01	1.09e-01
VLDLR internalisation and degradation	16	1.70e-01	3.66e-01	0.30100	1.99e-01	0.226000	1.69e-01	1.18e-01
SUMOylation of DNA replication proteins	44	4.20e-03	2.42e-02	0.30000	8.85e-02	0.287000	3.10e-01	9.80e-04
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	2.65e-01	4.79e-01	0.30000	2.31e-01	0.192000	1.66e-01	2.50e-01
Paracetamol ADME	27	3.34e-02	1.21e-01	0.30000	-2.90e-01	-0.077200	9.20e-03	4.87e-01
Inflammasomes	21	9.11e-02	2.43e-01	0.29900	1.48e-01	0.260000	2.41e-01	3.89e-02
Regulation of TP53 Activity through Association with Co-factors	14	1.10e-01	2.78e-01	0.29900	-2.88e-01	0.080200	6.18e-02	6.03e-01
Synthesis of PIPs at the late endosome membrane	10	1.78e-01	3.76e-01	0.29900	-2.26e-01	0.196000	2.16e-01	2.84e-01
Transcription of the HIV genome	62	1.16e-03	8.27e-03	0.29900	2.22e-01	0.200000	2.51e-03	6.46e-03
S Phase	157	2.72e-08	6.47e-07	0.29900	1.65e-01	0.249000	3.59e-04	7.24e-08
Assembly Of The HIV Virion	16	1.47e-01	3.33e-01	0.29700	9.96e-02	0.280000	4.90e-01	5.24e-02
PRC2 methylates histones and DNA	13	1.20e-01	2.95e-01	0.29700	-1.23e-01	0.271000	4.42e-01	9.12e-02
Transport of Mature mRNAs Derived from Intronless Transcripts	41	6.28e-03	3.37e-02	0.29700	7.43e-02	0.287000	4.11e-01	1.46e-03
Formation of HIV elongation complex in the absence of HIV Tat	40	1.39e-02	6.13e-02	0.29600	2.11e-01	0.207000	2.07e-02	2.36e-02
HIV Transcription Initiation	43	9.28e-03	4.38e-02	0.29600	2.43e-01	0.168000	5.72e-03	5.71e-02
RNA Polymerase II HIV Promoter Escape	43	9.28e-03	4.38e-02	0.29600	2.43e-01	0.168000	5.72e-03	5.71e-02
RNA Polymerase II Promoter Escape	43	9.28e-03	4.38e-02	0.29600	2.43e-01	0.168000	5.72e-03	5.71e-02
RNA Polymerase II Transcription Initiation	43	9.28e-03	4.38e-02	0.29600	2.43e-01	0.168000	5.72e-03	5.71e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	9.28e-03	4.38e-02	0.29600	2.43e-01	0.168000	5.72e-03	5.71e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	9.28e-03	4.38e-02	0.29600	2.43e-01	0.168000	5.72e-03	5.71e-02
Tie2 Signaling	18	7.09e-02	2.06e-01	0.29600	-2.92e-01	0.043400	3.17e-02	7.50e-01
Regulation of RUNX1 Expression and Activity	25	2.18e-02	8.66e-02	0.29500	-2.86e-01	0.074500	1.33e-02	5.19e-01
IRAK4 deficiency (TLR2/4)	17	5.84e-02	1.80e-01	0.29500	-1.73e-01	0.239000	2.17e-01	8.77e-02
G2/M Checkpoints	129	8.44e-07	1.28e-05	0.29500	1.62e-01	0.246000	1.45e-03	1.35e-06
Degradation of beta-catenin by the destruction complex	81	1.81e-04	1.55e-03	0.29500	1.93e-01	0.223000	2.67e-03	5.22e-04
Negative regulation of FLT3	15	1.80e-01	3.78e-01	0.29500	2.70e-01	0.118000	7.03e-02	4.28e-01
Chemokine receptors bind chemokines	56	1.26e-04	1.11e-03	0.29500	2.68e-01	-0.123000	5.24e-04	1.12e-01
Transcriptional regulation by RUNX3	93	5.27e-05	5.09e-04	0.29400	2.18e-01	0.197000	2.69e-04	9.95e-04
Cytochrome c-mediated apoptotic response	12	1.57e-01	3.48e-01	0.29400	2.80e-01	-0.089600	9.34e-02	5.91e-01
RIP-mediated NFkB activation via ZBP1	16	1.82e-01	3.80e-01	0.29300	1.71e-01	0.238000	2.37e-01	9.94e-02
Membrane binding and targetting of GAG proteins	14	2.05e-01	4.02e-01	0.29300	1.15e-01	0.269000	4.57e-01	8.10e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	2.05e-01	4.02e-01	0.29300	1.15e-01	0.269000	4.57e-01	8.10e-02
Nucleotide salvage	21	4.37e-02	1.47e-01	0.29200	-7.02e-02	0.284000	5.78e-01	2.44e-02
Viral Messenger RNA Synthesis	42	1.11e-02	5.07e-02	0.29200	1.56e-01	0.247000	8.11e-02	5.55e-03
Interactions of Vpr with host cellular proteins	33	1.37e-02	6.03e-02	0.29200	2.11e-02	0.291000	8.33e-01	3.79e-03
Collagen chain trimerization	42	6.20e-03	3.34e-02	0.29200	-6.59e-02	-0.284000	4.60e-01	1.43e-03
HSF1 activation	27	6.00e-02	1.83e-01	0.29200	2.15e-01	0.197000	5.30e-02	7.62e-02
Nuclear events stimulated by ALK signaling in cancer	18	8.72e-02	2.36e-01	0.29200	-6.14e-03	0.292000	9.64e-01	3.22e-02
Regulation of PTEN stability and activity	66	1.06e-03	7.80e-03	0.29100	1.97e-01	0.215000	5.65e-03	2.54e-03
Synthesis of glycosylphosphatidylinositol (GPI)	17	8.73e-02	2.36e-01	0.29100	-4.64e-02	0.287000	7.41e-01	4.02e-02
RNA polymerase II transcribes snRNA genes	77	3.40e-04	2.76e-03	0.29100	1.86e-01	0.224000	4.84e-03	6.83e-04
Alpha-protein kinase 1 signaling pathway	10	3.52e-01	5.68e-01	0.29100	1.76e-01	0.231000	3.34e-01	2.06e-01
Defective pyroptosis	11	2.19e-01	4.20e-01	0.29100	-2.29e-02	0.290000	8.95e-01	9.60e-02
ABC transporter disorders	75	3.19e-04	2.59e-03	0.29100	2.53e-01	0.143000	1.50e-04	3.26e-02
ABC transporters in lipid homeostasis	17	1.37e-01	3.21e-01	0.29000	-8.07e-02	-0.279000	5.65e-01	4.65e-02
Transport of the SLBP independent Mature mRNA	33	2.43e-02	9.41e-02	0.29000	1.05e-01	0.271000	2.97e-01	7.14e-03
Formation of TC-NER Pre-Incision Complex	51	5.22e-03	2.89e-02	0.29000	2.22e-01	0.186000	6.06e-03	2.14e-02
MET activates RAP1 and RAC1	11	1.79e-01	3.78e-01	0.28900	-2.59e-01	0.129000	1.37e-01	4.59e-01
Downstream TCR signaling	92	6.07e-05	5.73e-04	0.28900	2.49e-01	0.147000	3.64e-05	1.51e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	2.21e-01	4.23e-01	0.28900	-2.67e-02	0.288000	8.78e-01	9.86e-02
HIV Infection	216	2.74e-10	9.21e-09	0.28800	1.77e-01	0.227000	6.83e-06	8.11e-09
Pyrimidine salvage	10	2.07e-01	4.03e-01	0.28800	-1.47e-01	0.248000	4.21e-01	1.74e-01
Vpr-mediated nuclear import of PICs	32	1.79e-02	7.41e-02	0.28800	2.45e-02	0.287000	8.11e-01	4.98e-03
ATF6 (ATF6-alpha) activates chaperone genes	10	3.60e-01	5.74e-01	0.28700	1.74e-01	0.229000	3.42e-01	2.10e-01
B-WICH complex positively regulates rRNA expression	29	5.37e-02	1.69e-01	0.28700	2.03e-01	0.203000	5.83e-02	5.84e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	5.19e-02	1.66e-01	0.28700	2.81e-01	0.058000	1.50e-02	6.16e-01
Cleavage of the damaged purine	11	1.76e-01	3.73e-01	0.28700	-1.75e-01	0.227000	3.15e-01	1.92e-01
Depurination	11	1.76e-01	3.73e-01	0.28700	-1.75e-01	0.227000	3.15e-01	1.92e-01
Recognition and association of DNA glycosylase with site containing an affected purine	11	1.76e-01	3.73e-01	0.28700	-1.75e-01	0.227000	3.15e-01	1.92e-01
Formation of RNA Pol II elongation complex	53	4.94e-03	2.75e-02	0.28600	1.96e-01	0.209000	1.34e-02	8.63e-03
RNA Polymerase II Transcription Elongation	53	4.94e-03	2.75e-02	0.28600	1.96e-01	0.209000	1.34e-02	8.63e-03
Advanced glycosylation endproduct receptor signaling	13	2.72e-01	4.87e-01	0.28600	2.06e-01	0.199000	1.99e-01	2.14e-01
The citric acid (TCA) cycle and respiratory electron transport	143	3.17e-07	5.32e-06	0.28600	1.35e-01	0.252000	5.30e-03	1.84e-07
Termination of O-glycan biosynthesis	25	8.07e-02	2.24e-01	0.28500	-2.27e-01	-0.173000	4.94e-02	1.34e-01
Ketone body metabolism	10	3.66e-01	5.80e-01	0.28500	-1.75e-01	-0.225000	3.38e-01	2.17e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	1.86e-01	3.81e-01	0.28500	4.09e-02	0.282000	7.91e-01	6.76e-02
Signal regulatory protein family interactions	13	1.33e-01	3.14e-01	0.28500	-1.64e-01	0.233000	3.06e-01	1.46e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	1.23e-01	2.98e-01	0.28500	-6.00e-02	0.278000	6.87e-01	6.20e-02
HIV Life Cycle	139	6.98e-07	1.09e-05	0.28500	1.47e-01	0.244000	2.82e-03	6.78e-07
SARS-CoV-1 Infection	134	1.56e-06	2.26e-05	0.28400	1.68e-01	0.229000	7.92e-04	4.45e-06
Transport of Mature mRNA Derived from an Intronless Transcript	40	1.10e-02	5.07e-02	0.28400	7.51e-02	0.274000	4.11e-01	2.70e-03
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	3.34e-02	1.21e-01	0.28300	1.60e-01	0.234000	1.06e-01	1.83e-02
Negative regulation of FGFR3 signaling	28	6.24e-02	1.89e-01	0.28300	1.68e-01	0.228000	1.25e-01	3.69e-02
TP53 Regulates Transcription of DNA Repair Genes	57	3.83e-03	2.27e-02	0.28300	2.02e-01	0.197000	8.19e-03	9.93e-03
RAB geranylgeranylation	57	2.40e-03	1.53e-02	0.28200	1.07e-01	0.261000	1.64e-01	6.41e-04
Killing mechanisms	11	3.10e-01	5.27e-01	0.28200	9.95e-02	0.263000	5.68e-01	1.30e-01
WNT5:FZD7-mediated leishmania damping	11	3.10e-01	5.27e-01	0.28200	9.95e-02	0.263000	5.68e-01	1.30e-01
Antigen processing-Cross presentation	100	6.60e-05	6.11e-04	0.28100	1.94e-01	0.203000	7.94e-04	4.45e-04
Assembly of active LPL and LIPC lipase complexes	17	7.48e-02	2.13e-01	0.28100	2.02e-01	-0.195000	1.49e-01	1.65e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	1.84e-01	3.80e-01	0.28100	2.40e-01	0.145000	8.63e-02	3.00e-01
Nuclear Pore Complex (NPC) Disassembly	34	1.95e-02	7.99e-02	0.28000	4.01e-02	0.277000	6.86e-01	5.18e-03
Regulation of PTEN mRNA translation	25	3.50e-02	1.24e-01	0.27800	-2.71e-01	0.062400	1.90e-02	5.89e-01
GRB2 events in EGFR signaling	13	1.97e-01	3.95e-01	0.27800	-2.77e-01	0.015100	8.33e-02	9.25e-01
Tryptophan catabolism	12	2.88e-01	5.08e-01	0.27700	-2.60e-01	-0.096000	1.18e-01	5.65e-01
Endosomal/Vacuolar pathway	12	2.63e-01	4.78e-01	0.27700	2.72e-01	0.051200	1.02e-01	7.59e-01
Downstream signaling events of B Cell Receptor (BCR)	78	6.60e-04	5.10e-03	0.27700	2.08e-01	0.183000	1.48e-03	5.20e-03
Cytosolic sulfonation of small molecules	21	4.51e-02	1.50e-01	0.27700	-1.71e-01	0.218000	1.75e-01	8.43e-02
Transport of organic anions	10	3.88e-01	5.98e-01	0.27600	-2.22e-01	-0.164000	2.23e-01	3.70e-01
CLEC7A (Dectin-1) signaling	96	1.27e-04	1.12e-03	0.27600	1.72e-01	0.216000	3.57e-03	2.61e-04
Protein ubiquitination	61	2.49e-03	1.56e-02	0.27600	1.23e-01	0.247000	9.71e-02	8.51e-04
Formation of the Early Elongation Complex	32	5.10e-02	1.65e-01	0.27600	2.05e-01	0.184000	4.43e-02	7.21e-02
Formation of the HIV-1 Early Elongation Complex	32	5.10e-02	1.65e-01	0.27600	2.05e-01	0.184000	4.43e-02	7.21e-02
Late Phase of HIV Life Cycle	126	6.43e-06	7.71e-05	0.27500	1.48e-01	0.232000	4.19e-03	6.58e-06
Transport of Ribonucleoproteins into the Host Nucleus	30	4.41e-02	1.48e-01	0.27500	8.32e-02	0.262000	4.30e-01	1.29e-02
CYP2E1 reactions	11	3.45e-01	5.61e-01	0.27500	-2.41e-01	-0.132000	1.66e-01	4.48e-01
Presynaptic nicotinic acetylcholine receptors	12	3.30e-01	5.45e-01	0.27500	1.98e-01	0.191000	2.36e-01	2.52e-01
Downregulation of ERBB2:ERBB3 signaling	13	2.99e-01	5.16e-01	0.27500	1.75e-01	0.212000	2.76e-01	1.86e-01
Glutamate and glutamine metabolism	12	2.21e-01	4.24e-01	0.27400	-3.81e-02	0.271000	8.19e-01	1.04e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	3.58e-01	5.73e-01	0.27400	8.40e-02	0.260000	6.46e-01	1.54e-01
Unfolded Protein Response (UPR)	90	2.56e-04	2.14e-03	0.27300	1.71e-01	0.214000	5.14e-03	4.54e-04
Transcriptional Regulation by E2F6	32	1.50e-02	6.48e-02	0.27300	-7.08e-02	0.264000	4.88e-01	9.72e-03
Postmitotic nuclear pore complex (NPC) reformation	26	8.66e-02	2.36e-01	0.27300	1.43e-01	0.233000	2.07e-01	3.99e-02
WNT5A-dependent internalization of FZD4	15	2.51e-01	4.66e-01	0.27300	2.20e-01	0.161000	1.40e-01	2.79e-01
FGFR2c ligand binding and activation	12	3.29e-01	5.45e-01	0.27200	1.52e-01	0.226000	3.61e-01	1.76e-01
NS1 Mediated Effects on Host Pathways	39	2.01e-02	8.18e-02	0.27200	8.96e-02	0.256000	3.33e-01	5.57e-03
Defective B3GALTL causes PpS	36	2.43e-02	9.41e-02	0.27100	-6.97e-02	-0.262000	4.69e-01	6.44e-03
Signaling by Activin	15	2.55e-01	4.70e-01	0.27100	2.17e-01	0.162000	1.45e-01	2.76e-01
Phospholipase C-mediated cascade; FGFR3	12	3.38e-01	5.53e-01	0.27100	1.70e-01	0.211000	3.09e-01	2.05e-01
Acyl chain remodelling of PI	16	1.21e-01	2.97e-01	0.27100	8.57e-02	-0.257000	5.53e-01	7.49e-02
Xenobiotics	24	1.11e-01	2.79e-01	0.27100	-1.50e-01	-0.225000	2.03e-01	5.58e-02
Negative regulators of DDX58/IFIH1 signaling	34	2.88e-02	1.08e-01	0.27100	5.97e-02	0.264000	5.47e-01	7.73e-03
E3 ubiquitin ligases ubiquitinate target proteins	43	1.72e-02	7.26e-02	0.27000	1.22e-01	0.242000	1.67e-01	6.12e-03
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	7.60e-02	2.14e-01	0.27000	1.41e-01	0.231000	1.98e-01	3.47e-02
G0 and Early G1	27	6.55e-02	1.96e-01	0.27000	7.60e-02	0.259000	4.94e-01	1.99e-02
Fanconi Anemia Pathway	36	4.06e-02	1.39e-01	0.27000	1.79e-01	0.201000	6.28e-02	3.65e-02
Laminin interactions	23	1.30e-01	3.09e-01	0.26900	-1.82e-01	-0.198000	1.30e-01	9.95e-02
Regulation of NF-kappa B signaling	17	2.11e-01	4.08e-01	0.26900	2.29e-01	0.141000	1.01e-01	3.14e-01
SHC1 events in EGFR signaling	14	1.65e-01	3.60e-01	0.26900	-2.57e-01	0.079200	9.61e-02	6.08e-01
SARS-CoV-2 modulates autophagy	11	3.03e-01	5.18e-01	0.26800	2.71e-02	0.267000	8.76e-01	1.25e-01
Regulation of TP53 Activity through Phosphorylation	88	4.25e-04	3.40e-03	0.26800	1.74e-01	0.204000	4.73e-03	9.19e-04
Interaction between L1 and Ankyrins	28	3.39e-02	1.22e-01	0.26800	3.74e-02	-0.266000	7.32e-01	1.49e-02
SHC1 events in ERBB4 signaling	14	1.54e-01	3.43e-01	0.26800	-2.41e-01	0.117000	1.18e-01	4.47e-01
Transcription of E2F targets under negative control by DREAM complex	19	1.72e-01	3.69e-01	0.26800	1.23e-01	0.238000	3.54e-01	7.22e-02
tRNA processing	98	1.74e-04	1.50e-03	0.26800	1.61e-01	0.214000	5.83e-03	2.55e-04
TNFR1-induced NFkappaB signaling pathway	22	1.46e-01	3.32e-01	0.26800	1.86e-01	0.192000	1.30e-01	1.19e-01
Induction of Cell-Cell Fusion	12	3.45e-01	5.61e-01	0.26700	-1.59e-01	-0.215000	3.41e-01	1.97e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	1.97e-01	3.95e-01	0.26700	-6.49e-02	0.259000	6.86e-01	1.05e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	2.65e-01	4.79e-01	0.26700	5.67e-02	0.261000	7.23e-01	1.03e-01
Calnexin/calreticulin cycle	25	1.13e-01	2.82e-01	0.26700	1.79e-01	0.198000	1.22e-01	8.58e-02
Reactions specific to the complex N-glycan synthesis pathway	10	4.10e-01	6.16e-01	0.26700	-2.24e-01	-0.144000	2.19e-01	4.31e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	5.37e-02	1.69e-01	0.26600	8.09e-02	0.254000	4.43e-01	1.61e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	5.37e-02	1.69e-01	0.26600	8.09e-02	0.254000	4.43e-01	1.61e-02
FOXO-mediated transcription of cell death genes	15	2.59e-01	4.73e-01	0.26600	2.30e-01	0.133000	1.22e-01	3.71e-01
ER Quality Control Compartment (ERQC)	20	1.77e-01	3.74e-01	0.26600	2.01e-01	0.174000	1.19e-01	1.78e-01
WNT ligand biogenesis and trafficking	25	1.15e-01	2.87e-01	0.26600	1.77e-01	0.198000	1.26e-01	8.61e-02
SUMOylation of RNA binding proteins	45	9.85e-03	4.60e-02	0.26600	4.62e-02	0.262000	5.92e-01	2.40e-03
NoRC negatively regulates rRNA expression	43	2.08e-02	8.38e-02	0.26500	1.26e-01	0.233000	1.53e-01	8.09e-03
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	4.15e-01	6.20e-01	0.26500	2.21e-01	0.147000	2.27e-01	4.21e-01
Regulated proteolysis of p75NTR	11	3.59e-01	5.73e-01	0.26500	2.45e-01	0.102000	1.60e-01	5.59e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	1.66e-01	3.61e-01	0.26500	2.63e-01	0.027900	6.00e-02	8.42e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	1.28e-01	3.08e-01	0.26500	-1.94e-01	-0.180000	1.01e-01	1.26e-01
Antiviral mechanism by IFN-stimulated genes	78	1.07e-03	7.84e-03	0.26500	1.42e-01	0.223000	2.99e-02	6.57e-04
Drug ADME	104	1.34e-04	1.16e-03	0.26400	-2.06e-01	-0.166000	2.89e-04	3.41e-03
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	9.58e-02	2.51e-01	0.26400	1.46e-01	0.219000	1.88e-01	4.85e-02
FGFR2 ligand binding and activation	19	1.87e-01	3.82e-01	0.26400	2.28e-01	0.133000	8.57e-02	3.16e-01
Inhibition of DNA recombination at telomere	20	1.84e-01	3.80e-01	0.26300	1.82e-01	0.190000	1.60e-01	1.41e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	67	3.29e-03	1.99e-02	0.26200	1.54e-01	0.213000	2.92e-02	2.61e-03
Cellular response to chemical stress	187	7.84e-08	1.66e-06	0.26200	1.26e-01	0.230000	2.84e-03	5.72e-08
Activation of AMPK downstream of NMDARs	10	3.95e-01	6.04e-01	0.26200	8.85e-02	0.246000	6.28e-01	1.77e-01
MTOR signalling	40	8.14e-03	4.03e-02	0.26200	-6.83e-02	0.253000	4.55e-01	5.71e-03
Regulation of IFNA/IFNB signaling	22	1.52e-01	3.43e-01	0.26100	-1.44e-01	-0.218000	2.41e-01	7.67e-02
Regulation of RUNX2 expression and activity	71	2.70e-03	1.68e-02	0.26100	1.84e-01	0.185000	7.32e-03	6.87e-03
O-glycosylation of TSR domain-containing proteins	37	2.73e-02	1.03e-01	0.26100	-5.57e-02	-0.255000	5.58e-01	7.27e-03
Bile acid and bile salt metabolism	45	1.96e-02	8.01e-02	0.26100	-1.22e-01	-0.231000	1.56e-01	7.45e-03
Signaling by WNT in cancer	32	1.55e-02	6.67e-02	0.26100	-1.52e-01	0.212000	1.37e-01	3.80e-02
RNA Pol II CTD phosphorylation and interaction with CE	26	1.04e-01	2.65e-01	0.26100	2.30e-01	0.122000	4.21e-02	2.81e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	1.04e-01	2.65e-01	0.26100	2.30e-01	0.122000	4.21e-02	2.81e-01
Regulation of gene expression by Hypoxia-inducible Factor	11	3.84e-01	5.94e-01	0.26100	1.24e-01	0.229000	4.77e-01	1.88e-01
Mitochondrial tRNA aminoacylation	18	2.03e-01	4.01e-01	0.26100	1.11e-01	0.236000	4.16e-01	8.32e-02
Nucleotide-like (purinergic) receptors	13	3.33e-01	5.48e-01	0.26100	-2.15e-01	-0.147000	1.80e-01	3.58e-01
Mismatch Repair	15	2.87e-01	5.07e-01	0.26000	1.71e-01	0.196000	2.51e-01	1.88e-01
mTORC1-mediated signalling	23	7.17e-02	2.07e-01	0.26000	-4.10e-02	0.257000	7.34e-01	3.28e-02
HCMV Late Events	54	6.71e-03	3.55e-02	0.26000	7.99e-02	0.248000	3.10e-01	1.64e-03
RUNX3 regulates p14-ARF	10	4.18e-01	6.24e-01	0.26000	1.19e-01	0.231000	5.14e-01	2.06e-01
HSF1-dependent transactivation	35	5.31e-02	1.68e-01	0.26000	2.13e-01	0.149000	2.92e-02	1.28e-01
Negative epigenetic regulation of rRNA expression	45	2.09e-02	8.38e-02	0.26000	1.26e-01	0.227000	1.45e-01	8.37e-03
ISG15 antiviral mechanism	71	2.41e-03	1.53e-02	0.25900	1.33e-01	0.222000	5.21e-02	1.19e-03
SHC-mediated cascade:FGFR1	21	1.60e-01	3.53e-01	0.25900	1.14e-01	0.233000	3.68e-01	6.44e-02
FGFR3 mutant receptor activation	11	4.03e-01	6.11e-01	0.25900	1.66e-01	0.199000	3.41e-01	2.52e-01
Signaling by activated point mutants of FGFR3	11	4.03e-01	6.11e-01	0.25900	1.66e-01	0.199000	3.41e-01	2.52e-01
Transport of Mature Transcript to Cytoplasm	76	1.67e-03	1.11e-02	0.25900	1.37e-01	0.219000	3.82e-02	9.43e-04
tRNA Aminoacylation	24	1.04e-01	2.66e-01	0.25800	5.99e-02	0.251000	6.11e-01	3.35e-02
Collagen biosynthesis and modifying enzymes	65	4.00e-03	2.35e-02	0.25700	-1.20e-01	-0.228000	9.45e-02	1.50e-03
Purine catabolism	17	2.36e-01	4.46e-01	0.25700	2.27e-01	0.121000	1.06e-01	3.86e-01
Mitotic Metaphase and Anaphase	222	1.18e-08	3.21e-07	0.25700	1.40e-01	0.216000	3.31e-04	2.96e-08
ATF6 (ATF6-alpha) activates chaperones	11	4.08e-01	6.16e-01	0.25700	1.57e-01	0.203000	3.67e-01	2.43e-01
Regulated Necrosis	53	1.39e-02	6.13e-02	0.25700	1.92e-01	0.171000	1.57e-02	3.16e-02
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	2.78e-01	4.96e-01	0.25700	-7.03e-02	0.247000	6.87e-01	1.56e-01
Processing of Intronless Pre-mRNAs	19	1.80e-01	3.79e-01	0.25700	7.92e-02	0.244000	5.50e-01	6.55e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	2.67e-01	4.83e-01	0.25600	-2.51e-01	-0.054000	1.04e-01	7.26e-01
Budding and maturation of HIV virion	28	9.44e-02	2.48e-01	0.25600	1.18e-01	0.227000	2.79e-01	3.76e-02
FGFR2 alternative splicing	26	1.23e-01	2.99e-01	0.25600	2.01e-01	0.158000	7.67e-02	1.62e-01
Diseases associated with N-glycosylation of proteins	19	1.40e-01	3.26e-01	0.25500	-2.90e-03	0.255000	9.83e-01	5.38e-02
mRNA decay by 3’ to 5’ exoribonuclease	16	1.86e-01	3.81e-01	0.25500	2.55e-01	-0.011900	7.72e-02	9.34e-01
AKT phosphorylates targets in the cytosol	14	3.24e-01	5.42e-01	0.25500	1.54e-01	0.204000	3.19e-01	1.87e-01
RNA Polymerase III Abortive And Retractive Initiation	41	3.38e-02	1.22e-01	0.25500	1.26e-01	0.222000	1.63e-01	1.41e-02
RNA Polymerase III Transcription	41	3.38e-02	1.22e-01	0.25500	1.26e-01	0.222000	1.63e-01	1.41e-02
Detoxification of Reactive Oxygen Species	35	5.83e-02	1.79e-01	0.25500	1.39e-01	0.213000	1.54e-01	2.90e-02
Separation of Sister Chromatids	161	2.77e-06	3.53e-05	0.25400	1.53e-01	0.203000	8.33e-04	8.41e-06
Mitotic Anaphase	221	1.98e-08	4.95e-07	0.25400	1.37e-01	0.214000	4.50e-04	4.26e-08
Protein localization	147	8.40e-06	9.35e-05	0.25400	1.49e-01	0.205000	1.83e-03	1.68e-05
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	4.82e-02	1.58e-01	0.25400	2.21e-01	0.124000	1.99e-02	1.91e-01
Cell Cycle Checkpoints	248	1.53e-09	4.78e-08	0.25400	1.19e-01	0.224000	1.23e-03	1.22e-09
TP53 Regulates Transcription of Cell Cycle Genes	49	1.85e-02	7.65e-02	0.25300	1.25e-01	0.220000	1.29e-01	7.75e-03
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	11	3.11e-01	5.28e-01	0.25300	2.51e-01	-0.029000	1.49e-01	8.68e-01
Cytosolic sensors of pathogen-associated DNA	60	9.28e-03	4.38e-02	0.25300	1.78e-01	0.179000	1.68e-02	1.65e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	3.31e-01	5.46e-01	0.25200	1.45e-01	0.206000	3.49e-01	1.81e-01
RNA Polymerase III Chain Elongation	18	2.47e-01	4.61e-01	0.25200	1.81e-01	0.175000	1.83e-01	1.98e-01
Negative regulation of MAPK pathway	41	2.71e-02	1.02e-01	0.25200	6.97e-02	0.242000	4.40e-01	7.35e-03
Plasma lipoprotein remodeling	32	3.85e-02	1.34e-01	0.25200	9.99e-03	-0.251000	9.22e-01	1.38e-02
Transcriptional regulation by small RNAs	46	2.09e-02	8.38e-02	0.25200	9.50e-02	0.233000	2.65e-01	6.27e-03
Translocation of ZAP-70 to Immunological synapse	17	1.32e-01	3.13e-01	0.25100	2.15e-01	-0.129000	1.25e-01	3.56e-01
mRNA Capping	28	1.10e-01	2.78e-01	0.25000	2.11e-01	0.135000	5.30e-02	2.18e-01
RHO GTPases Activate NADPH Oxidases	22	7.50e-02	2.13e-01	0.25000	-1.20e-01	0.219000	3.29e-01	7.47e-02
DNA strand elongation	31	8.78e-02	2.36e-01	0.25000	1.36e-01	0.210000	1.89e-01	4.31e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	1.30e-01	3.09e-01	0.25000	-8.92e-02	0.233000	5.13e-01	8.63e-02
HDACs deacetylate histones	29	5.93e-02	1.81e-01	0.25000	6.12e-03	0.250000	9.55e-01	1.99e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	34	6.58e-02	1.96e-01	0.24900	1.14e-01	0.222000	2.52e-01	2.52e-02
SUMOylation of chromatin organization proteins	54	3.93e-03	2.32e-02	0.24900	-2.80e-02	0.247000	7.22e-01	1.67e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	3.65e-01	5.79e-01	0.24900	2.46e-01	0.034500	1.57e-01	8.43e-01
RHO GTPases Activate WASPs and WAVEs	34	7.66e-02	2.15e-01	0.24900	1.77e-01	0.175000	7.45e-02	7.75e-02
Intrinsic Pathway of Fibrin Clot Formation	21	1.97e-01	3.95e-01	0.24800	-1.34e-01	-0.209000	2.87e-01	9.77e-02
IRF3-mediated induction of type I IFN	11	3.87e-01	5.96e-01	0.24800	2.40e-01	0.064000	1.69e-01	7.13e-01
Fertilization	26	1.22e-01	2.97e-01	0.24700	-9.40e-02	-0.228000	4.07e-01	4.38e-02
Metabolism of porphyrins	27	1.02e-01	2.63e-01	0.24700	-6.85e-02	-0.237000	5.38e-01	3.30e-02
TP53 Regulates Metabolic Genes	83	1.02e-03	7.60e-03	0.24600	7.64e-02	0.234000	2.29e-01	2.23e-04
SHC-mediated cascade:FGFR3	17	2.03e-01	4.01e-01	0.24600	1.09e-02	0.246000	9.38e-01	7.92e-02
Acetylcholine binding and downstream events	14	3.22e-01	5.39e-01	0.24600	2.29e-01	0.089700	1.38e-01	5.61e-01
Postsynaptic nicotinic acetylcholine receptors	14	3.22e-01	5.39e-01	0.24600	2.29e-01	0.089700	1.38e-01	5.61e-01
Resolution of Abasic Sites (AP sites)	37	5.17e-02	1.66e-01	0.24600	9.43e-02	0.227000	3.21e-01	1.69e-02
p38MAPK events	13	2.34e-01	4.41e-01	0.24600	-1.04e-01	0.223000	5.18e-01	1.64e-01
MAPK6/MAPK4 signaling	89	1.42e-03	9.71e-03	0.24600	1.83e-01	0.164000	2.82e-03	7.59e-03
mRNA 3’-end processing	53	2.03e-02	8.20e-02	0.24500	1.62e-01	0.184000	4.09e-02	2.07e-02
FGFR2 mutant receptor activation	32	9.43e-02	2.48e-01	0.24500	1.93e-01	0.151000	5.91e-02	1.40e-01
RUNX3 regulates NOTCH signaling	13	3.33e-01	5.48e-01	0.24300	2.38e-01	0.052800	1.38e-01	7.42e-01
RAF-independent MAPK1/3 activation	22	2.03e-01	4.01e-01	0.24300	1.83e-01	0.160000	1.38e-01	1.93e-01
Pyrimidine catabolism	12	4.10e-01	6.16e-01	0.24300	-2.06e-01	-0.128000	2.16e-01	4.42e-01
Epigenetic regulation of gene expression	83	1.41e-03	9.71e-03	0.24200	8.38e-02	0.227000	1.87e-01	3.38e-04
Cell recruitment (pro-inflammatory response)	25	1.44e-01	3.31e-01	0.24200	9.52e-02	0.223000	4.10e-01	5.37e-02
Purinergic signaling in leishmaniasis infection	25	1.44e-01	3.31e-01	0.24200	9.52e-02	0.223000	4.10e-01	5.37e-02
Inactivation of CSF3 (G-CSF) signaling	23	1.78e-01	3.76e-01	0.24200	2.13e-01	0.114000	7.68e-02	3.43e-01
Signalling to RAS	20	1.19e-01	2.95e-01	0.24100	-9.45e-02	0.221000	4.65e-01	8.67e-02
Acetylcholine regulates insulin secretion	10	3.27e-01	5.45e-01	0.24000	-1.65e-01	0.175000	3.67e-01	3.39e-01
Activation of ATR in response to replication stress	37	4.81e-02	1.58e-01	0.24000	5.41e-02	0.234000	5.69e-01	1.38e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	2.59e-01	4.73e-01	0.24000	1.91e-01	0.145000	1.50e-01	2.72e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	2.59e-01	4.73e-01	0.24000	1.91e-01	0.145000	1.50e-01	2.72e-01
TP53 Regulates Transcription of Cell Death Genes	42	2.30e-02	9.03e-02	0.23900	3.47e-03	0.239000	9.69e-01	7.27e-03
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	2.46e-01	4.61e-01	0.23900	1.72e-01	0.167000	1.84e-01	1.97e-01
ZBP1(DAI) mediated induction of type I IFNs	20	2.47e-01	4.61e-01	0.23900	1.63e-01	0.175000	2.07e-01	1.76e-01
VEGFR2 mediated vascular permeability	26	8.84e-02	2.36e-01	0.23800	-2.37e-01	0.021700	3.62e-02	8.48e-01
Chaperone Mediated Autophagy	19	2.02e-01	4.00e-01	0.23800	2.36e-01	0.031600	7.48e-02	8.12e-01
Collagen degradation	39	6.36e-02	1.92e-01	0.23800	-1.35e-01	-0.196000	1.45e-01	3.38e-02
MET receptor recycling	10	3.35e-01	5.50e-01	0.23800	-1.81e-01	0.155000	3.23e-01	3.96e-01
Phosphorylation of CD3 and TCR zeta chains	20	1.38e-01	3.22e-01	0.23800	2.30e-01	-0.059800	7.46e-02	6.43e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	41	5.90e-02	1.81e-01	0.23700	1.54e-01	0.180000	8.71e-02	4.58e-02
Recognition of DNA damage by PCNA-containing replication complex	29	1.36e-01	3.21e-01	0.23700	1.74e-01	0.161000	1.05e-01	1.34e-01
Signal amplification	33	2.81e-02	1.05e-01	0.23700	-1.79e-01	0.155000	7.46e-02	1.24e-01
Processing of DNA double-strand break ends	61	1.26e-02	5.63e-02	0.23700	1.11e-01	0.209000	1.32e-01	4.80e-03
TCR signaling	112	2.90e-04	2.38e-03	0.23600	2.15e-01	0.097000	8.41e-05	7.59e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	2.56e-01	4.70e-01	0.23600	2.31e-01	0.046100	9.87e-02	7.42e-01
Regulation of PTEN gene transcription	59	3.82e-03	2.27e-02	0.23600	-4.11e-02	0.232000	5.85e-01	2.05e-03
RNA Polymerase II Transcription Termination	62	1.49e-02	6.45e-02	0.23600	1.57e-01	0.176000	3.28e-02	1.66e-02
Pentose phosphate pathway	12	2.99e-01	5.16e-01	0.23500	-8.37e-02	0.220000	6.15e-01	1.87e-01
Cyclin A/B1/B2 associated events during G2/M transition	24	1.53e-01	3.43e-01	0.23500	5.66e-02	0.228000	6.31e-01	5.27e-02
Signaling by NOTCH3	48	2.49e-02	9.54e-02	0.23500	2.26e-01	0.063400	6.65e-03	4.48e-01
Triglyceride catabolism	23	1.68e-01	3.64e-01	0.23500	-6.04e-02	-0.227000	6.16e-01	5.93e-02
Negative regulation of FGFR2 signaling	33	1.06e-01	2.70e-01	0.23500	1.44e-01	0.185000	1.51e-01	6.54e-02
Role of LAT2/NTAL/LAB on calcium mobilization	13	3.87e-01	5.96e-01	0.23500	-2.17e-01	-0.089900	1.76e-01	5.75e-01
Signaling by FGFR2	72	7.95e-03	3.97e-02	0.23400	1.60e-01	0.171000	1.89e-02	1.19e-02
Mitotic G2-G2/M phases	177	5.95e-06	7.19e-05	0.23400	1.32e-01	0.194000	2.51e-03	8.75e-06
Metalloprotease DUBs	19	2.01e-01	4.00e-01	0.23300	9.03e-03	0.233000	9.46e-01	7.85e-02
Base Excision Repair	45	3.20e-02	1.17e-01	0.23300	5.56e-02	0.226000	5.19e-01	8.72e-03
Diseases associated with O-glycosylation of proteins	66	1.20e-02	5.45e-02	0.23300	-1.37e-01	-0.188000	5.47e-02	8.20e-03
Degradation of cysteine and homocysteine	14	3.48e-01	5.64e-01	0.23300	6.24e-02	0.224000	6.86e-01	1.47e-01
Thromboxane signalling through TP receptor	24	8.60e-02	2.36e-01	0.23200	-1.21e-01	0.198000	3.05e-01	9.27e-02
Cellular response to heat stress	95	1.66e-03	1.11e-02	0.23200	1.27e-01	0.194000	3.25e-02	1.05e-03
Chylomicron assembly	10	5.12e-01	7.00e-01	0.23200	-1.32e-01	-0.191000	4.70e-01	2.96e-01
Regulation of HSF1-mediated heat shock response	78	4.88e-03	2.73e-02	0.23100	1.11e-01	0.203000	8.96e-02	1.95e-03
MET promotes cell motility	29	1.40e-01	3.26e-01	0.23100	-2.00e-01	-0.116000	6.22e-02	2.80e-01
SUMOylation of DNA methylation proteins	16	1.95e-01	3.94e-01	0.23100	-1.36e-01	0.186000	3.46e-01	1.97e-01
PCNA-Dependent Long Patch Base Excision Repair	21	2.50e-01	4.66e-01	0.23000	1.34e-01	0.188000	2.88e-01	1.37e-01
Nuclear Envelope Breakdown	50	2.03e-02	8.21e-02	0.23000	3.37e-02	0.227000	6.80e-01	5.40e-03
G2/M Transition	175	1.08e-05	1.17e-04	0.22900	1.28e-01	0.190000	3.34e-03	1.42e-05
Signaling by CSF3 (G-CSF)	28	1.67e-01	3.62e-01	0.22800	1.57e-01	0.166000	1.50e-01	1.29e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	3.84e-01	5.94e-01	0.22800	1.67e-01	0.155000	2.63e-01	2.97e-01
Disorders of Developmental Biology	11	3.74e-01	5.85e-01	0.22800	-4.69e-02	0.223000	7.88e-01	2.00e-01
Disorders of Nervous System Development	11	3.74e-01	5.85e-01	0.22800	-4.69e-02	0.223000	7.88e-01	2.00e-01
Loss of function of MECP2 in Rett syndrome	11	3.74e-01	5.85e-01	0.22800	-4.69e-02	0.223000	7.88e-01	2.00e-01
Pervasive developmental disorders	11	3.74e-01	5.85e-01	0.22800	-4.69e-02	0.223000	7.88e-01	2.00e-01
HDL remodeling	10	4.58e-01	6.66e-01	0.22800	-2.34e-02	-0.227000	8.98e-01	2.15e-01
Interleukin-10 signaling	45	4.68e-02	1.54e-01	0.22700	2.08e-01	0.090800	1.56e-02	2.92e-01
Processing of Capped Intronless Pre-mRNA	28	1.50e-01	3.39e-01	0.22700	9.34e-02	0.207000	3.92e-01	5.77e-02
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	3.57e-01	5.72e-01	0.22700	-2.85e-02	0.225000	8.64e-01	1.77e-01
SUMOylation of intracellular receptors	29	5.57e-02	1.74e-01	0.22700	-1.66e-01	0.155000	1.22e-01	1.50e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	12	3.42e-01	5.59e-01	0.22700	-2.20e-01	0.052800	1.86e-01	7.52e-01
Cell Cycle, Mitotic	476	2.59e-14	1.82e-12	0.22700	9.83e-02	0.204000	2.34e-04	1.99e-14
MECP2 regulates neuronal receptors and channels	17	2.12e-01	4.09e-01	0.22700	-2.17e-01	0.065400	1.21e-01	6.40e-01
Activation of HOX genes during differentiation	61	8.99e-03	4.36e-02	0.22600	2.28e-02	0.225000	7.58e-01	2.33e-03
Activation of anterior HOX genes in hindbrain development during early embryogenesis	61	8.99e-03	4.36e-02	0.22600	2.28e-02	0.225000	7.58e-01	2.33e-03
Cellular responses to stress	682	3.08e-19	5.29e-17	0.22600	1.24e-01	0.189000	3.43e-08	2.80e-17
Metabolism of steroid hormones	33	5.51e-02	1.72e-01	0.22600	4.61e-02	-0.221000	6.47e-01	2.78e-02
Cholesterol biosynthesis	24	2.23e-01	4.26e-01	0.22600	1.73e-01	0.145000	1.43e-01	2.18e-01
Cellular responses to stimuli	696	1.62e-19	3.14e-17	0.22500	1.22e-01	0.189000	3.36e-08	1.38e-17
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	8.73e-02	2.36e-01	0.22400	1.08e-01	0.196000	2.48e-01	3.62e-02
DNA Double Strand Break Response	42	7.39e-02	2.11e-01	0.22400	1.36e-01	0.178000	1.28e-01	4.56e-02
Transcriptional Regulation by TP53	346	1.75e-10	6.02e-09	0.22400	9.32e-02	0.204000	2.85e-03	7.01e-11
Keratan sulfate degradation	12	3.95e-01	6.04e-01	0.22300	-2.23e-01	-0.008010	1.81e-01	9.62e-01
Neddylation	228	7.35e-07	1.14e-05	0.22300	1.20e-01	0.188000	1.81e-03	9.83e-07
Regulation of localization of FOXO transcription factors	11	4.81e-01	6.78e-01	0.22300	-2.08e-01	-0.080900	2.33e-01	6.42e-01
Macroautophagy	111	4.39e-04	3.50e-03	0.22300	5.47e-02	0.216000	3.19e-01	8.48e-05
Interleukin-1 signaling	109	1.39e-03	9.63e-03	0.22200	1.55e-01	0.159000	5.13e-03	4.01e-03
Interconversion of nucleotide di- and triphosphates	29	1.20e-01	2.96e-01	0.22200	2.99e-02	0.220000	7.80e-01	4.04e-02
Nucleotide Excision Repair	107	1.64e-03	1.10e-02	0.22200	1.56e-01	0.158000	5.27e-03	4.85e-03
Hedgehog ‘off’ state	97	2.87e-03	1.77e-02	0.22100	1.76e-01	0.134000	2.73e-03	2.23e-02
Signaling by FGFR2 IIIa TM	19	3.13e-01	5.30e-01	0.22100	1.84e-01	0.122000	1.64e-01	3.57e-01
Deposition of new CENPA-containing nucleosomes at the centromere	26	1.35e-01	3.18e-01	0.22100	-2.47e-04	0.221000	9.98e-01	5.12e-02
Nucleosome assembly	26	1.35e-01	3.18e-01	0.22100	-2.47e-04	0.221000	9.98e-01	5.12e-02
DNA Damage Bypass	46	5.81e-02	1.79e-01	0.22000	1.08e-01	0.192000	2.07e-01	2.40e-02
Negative regulation of FGFR4 signaling	30	1.65e-01	3.60e-01	0.22000	1.31e-01	0.177000	2.15e-01	9.31e-02
Transcriptional regulation of pluripotent stem cells	30	6.04e-02	1.84e-01	0.22000	-1.49e-01	0.162000	1.58e-01	1.25e-01
Phase 0 - rapid depolarisation	31	6.10e-02	1.86e-01	0.22000	1.00e-01	-0.195000	3.33e-01	5.96e-02
Signaling by PDGFR in disease	20	2.08e-01	4.04e-01	0.22000	-2.19e-01	0.014400	8.98e-02	9.11e-01
Nuclear Envelope (NE) Reassembly	73	1.10e-02	5.07e-02	0.21900	1.02e-01	0.194000	1.32e-01	4.11e-03
Oncogene Induced Senescence	35	1.28e-01	3.08e-01	0.21900	1.48e-01	0.162000	1.31e-01	9.72e-02
ERK/MAPK targets	20	2.28e-01	4.32e-01	0.21900	1.09e-02	0.219000	9.33e-01	9.05e-02
Initial triggering of complement	21	1.53e-01	3.43e-01	0.21900	1.01e-01	-0.194000	4.25e-01	1.23e-01
Biosynthesis of specialized proresolving mediators (SPMs)	19	1.72e-01	3.69e-01	0.21900	-1.51e-01	0.159000	2.56e-01	2.32e-01
The phototransduction cascade	32	1.28e-01	3.08e-01	0.21800	-7.51e-02	-0.205000	4.62e-01	4.48e-02
Synthesis of PE	12	4.00e-01	6.09e-01	0.21800	-7.51e-03	0.218000	9.64e-01	1.91e-01
M Phase	335	1.29e-09	4.16e-08	0.21800	9.47e-02	0.196000	2.85e-03	6.14e-10
Binding and Uptake of Ligands by Scavenger Receptors	41	8.69e-02	2.36e-01	0.21800	-1.84e-01	-0.117000	4.17e-02	1.95e-01
Synthesis of bile acids and bile salts	34	1.39e-01	3.26e-01	0.21700	-1.42e-01	-0.165000	1.51e-01	9.68e-02
ADP signalling through P2Y purinoceptor 1	25	1.03e-01	2.65e-01	0.21700	-1.71e-01	0.135000	1.40e-01	2.43e-01
Neutrophil degranulation	458	9.69e-16	9.98e-14	0.21700	-1.42e-02	0.217000	6.02e-01	1.63e-15
Collagen formation	88	5.37e-03	2.97e-02	0.21700	-1.11e-01	-0.186000	7.15e-02	2.51e-03
Calcitonin-like ligand receptors	10	5.32e-01	7.13e-01	0.21700	-2.03e-01	-0.077300	2.67e-01	6.72e-01
Na+/Cl- dependent neurotransmitter transporters	18	2.01e-01	4.00e-01	0.21600	1.82e-01	-0.116000	1.80e-01	3.93e-01
Pre-NOTCH Processing in Golgi	18	2.34e-01	4.41e-01	0.21600	-4.75e-02	0.211000	7.27e-01	1.22e-01
Hormone ligand-binding receptors	13	4.22e-01	6.27e-01	0.21600	-4.80e-02	-0.210000	7.64e-01	1.89e-01
Maturation of nucleoprotein 9683610	11	4.12e-01	6.18e-01	0.21600	4.70e-02	-0.211000	7.87e-01	2.26e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	1.33e-02	5.90e-02	0.21600	1.53e-01	0.152000	2.12e-02	2.17e-02
Autophagy	125	2.87e-04	2.37e-03	0.21500	5.21e-02	0.209000	3.14e-01	5.39e-05
Protein methylation	16	3.37e-01	5.53e-01	0.21500	3.46e-02	0.212000	8.11e-01	1.41e-01
Homology Directed Repair	99	2.99e-03	1.83e-02	0.21500	1.06e-01	0.187000	6.92e-02	1.28e-03
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	2.42e-01	4.54e-01	0.21300	9.29e-02	0.192000	4.31e-01	1.03e-01
Beta-catenin phosphorylation cascade	16	2.76e-01	4.93e-01	0.21300	-5.91e-02	0.205000	6.82e-01	1.56e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	31	1.61e-01	3.54e-01	0.21300	9.38e-02	0.191000	3.66e-01	6.50e-02
Mitotic Prophase	78	7.09e-03	3.64e-02	0.21300	5.28e-02	0.206000	4.20e-01	1.66e-03
trans-Golgi Network Vesicle Budding	67	4.37e-03	2.49e-02	0.21300	-6.91e-02	0.201000	3.28e-01	4.44e-03
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	4.28e-01	6.33e-01	0.21200	1.79e-01	0.115000	2.31e-01	4.41e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	4.28e-01	6.33e-01	0.21200	1.79e-01	0.115000	2.31e-01	4.41e-01
Cell-cell junction organization	56	4.58e-02	1.52e-01	0.21200	-1.44e-01	-0.156000	6.25e-02	4.33e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	25	2.52e-01	4.66e-01	0.21200	1.53e-01	0.148000	1.87e-01	2.02e-01
TNFs bind their physiological receptors	25	1.88e-01	3.82e-01	0.21200	2.10e-01	0.027700	6.88e-02	8.10e-01
Activation of SMO	17	3.53e-01	5.69e-01	0.21200	6.84e-02	0.201000	6.25e-01	1.52e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	93	4.78e-03	2.69e-02	0.21200	9.96e-02	0.187000	9.67e-02	1.82e-03
Global Genome Nucleotide Excision Repair (GG-NER)	81	1.17e-02	5.32e-02	0.21200	1.37e-01	0.161000	3.24e-02	1.21e-02
Signaling by FLT3 fusion proteins	19	2.02e-01	4.00e-01	0.21200	-1.86e-01	0.101000	1.60e-01	4.45e-01
Signaling by FGFR3	39	9.80e-02	2.55e-01	0.21200	8.02e-02	0.196000	3.86e-01	3.42e-02
Telomere C-strand synthesis initiation	11	4.67e-01	6.71e-01	0.21200	9.64e-03	0.211000	9.56e-01	2.25e-01
HCMV Infection	79	7.34e-03	3.74e-02	0.21100	5.36e-02	0.204000	4.10e-01	1.73e-03
Generation of second messenger molecules	30	7.73e-02	2.16e-01	0.21100	1.31e-01	-0.165000	2.15e-01	1.18e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	3.40e-02	1.22e-01	0.21000	1.65e-01	0.131000	2.45e-02	7.53e-02
DNA Repair	276	2.72e-07	4.84e-06	0.21000	1.15e-01	0.176000	1.04e-03	4.66e-07
Cellular hexose transport	21	1.91e-01	3.86e-01	0.21000	1.99e-01	-0.066100	1.14e-01	6.00e-01
Diseases associated with the TLR signaling cascade	29	9.58e-02	2.51e-01	0.21000	-8.28e-02	0.193000	4.40e-01	7.23e-02
Diseases of Immune System	29	9.58e-02	2.51e-01	0.21000	-8.28e-02	0.193000	4.40e-01	7.23e-02
RNA Polymerase I Transcription Termination	27	2.34e-01	4.41e-01	0.21000	1.55e-01	0.142000	1.64e-01	2.02e-01
Peroxisomal lipid metabolism	28	2.16e-01	4.15e-01	0.20900	1.16e-01	0.174000	2.88e-01	1.11e-01
RNA Polymerase I Promoter Clearance	46	7.09e-02	2.06e-01	0.20900	8.35e-02	0.192000	3.27e-01	2.45e-02
RHOJ GTPase cycle	51	3.42e-02	1.22e-01	0.20900	-2.08e-01	-0.017900	1.01e-02	8.25e-01
Cell Cycle	601	2.17e-15	2.01e-13	0.20800	8.16e-02	0.192000	6.15e-04	8.32e-16
Initiation of Nuclear Envelope (NE) Reformation	18	3.87e-01	5.96e-01	0.20700	1.32e-01	0.160000	3.32e-01	2.41e-01
Signaling by FGFR1	49	6.82e-02	2.00e-01	0.20700	9.95e-02	0.182000	2.28e-01	2.78e-02
BBSome-mediated cargo-targeting to cilium	23	2.71e-01	4.87e-01	0.20700	1.91e-01	0.080200	1.13e-01	5.06e-01
PI-3K cascade:FGFR1	21	3.26e-01	5.45e-01	0.20700	1.71e-01	0.115000	1.74e-01	3.60e-01
Plasma lipoprotein assembly	19	3.73e-01	5.85e-01	0.20600	-1.52e-01	-0.139000	2.50e-01	2.96e-01
Toll Like Receptor 3 (TLR3) Cascade	99	4.01e-03	2.35e-02	0.20600	8.17e-02	0.189000	1.60e-01	1.15e-03
FRS-mediated FGFR1 signaling	23	2.88e-01	5.08e-01	0.20600	9.91e-02	0.180000	4.10e-01	1.34e-01
PD-1 signaling	21	1.86e-01	3.81e-01	0.20600	1.76e-01	-0.106000	1.62e-01	4.01e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	3.76e-01	5.86e-01	0.20500	1.41e-01	0.149000	2.86e-01	2.61e-01
Inactivation, recovery and regulation of the phototransduction cascade	31	1.77e-01	3.75e-01	0.20500	-7.79e-02	-0.190000	4.53e-01	6.74e-02
Caspase activation via Death Receptors in the presence of ligand	16	4.37e-01	6.44e-01	0.20500	1.27e-01	0.161000	3.79e-01	2.66e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	15	3.21e-01	5.39e-01	0.20400	-1.90e-01	0.074200	2.03e-01	6.19e-01
NOTCH3 Intracellular Domain Regulates Transcription	24	2.74e-01	4.92e-01	0.20400	1.83e-01	0.089800	1.21e-01	4.46e-01
Ribavirin ADME	11	4.71e-01	6.72e-01	0.20400	-2.04e-02	0.203000	9.07e-01	2.44e-01
TAK1-dependent IKK and NF-kappa-B activation	41	1.23e-01	2.98e-01	0.20300	1.22e-01	0.163000	1.75e-01	7.17e-02
Triglyceride metabolism	36	9.80e-02	2.55e-01	0.20300	-4.68e-03	-0.203000	9.61e-01	3.48e-02
TP53 Regulates Transcription of Death Receptors and Ligands	12	5.18e-01	7.04e-01	0.20300	7.75e-02	0.188000	6.42e-01	2.60e-01
Metabolism of cofactors	19	3.82e-01	5.93e-01	0.20300	1.32e-01	0.155000	3.20e-01	2.43e-01
RNA Polymerase I Transcription	47	7.64e-02	2.15e-01	0.20300	7.67e-02	0.188000	3.63e-01	2.58e-02
Interleukin-20 family signaling	24	2.51e-01	4.66e-01	0.20300	-5.25e-02	-0.196000	6.56e-01	9.66e-02
Transcriptional regulation by RUNX2	116	2.79e-03	1.73e-02	0.20300	1.22e-01	0.162000	2.34e-02	2.54e-03
Organic anion transporters	10	4.68e-01	6.71e-01	0.20200	8.72e-02	-0.182000	6.33e-01	3.18e-01
Dual incision in TC-NER	63	4.37e-02	1.47e-01	0.20100	1.57e-01	0.125000	3.09e-02	8.54e-02
SUMOylation of DNA damage response and repair proteins	71	9.29e-03	4.38e-02	0.20100	-1.56e-02	0.200000	8.20e-01	3.49e-03
Presynaptic depolarization and calcium channel opening	12	5.39e-01	7.21e-01	0.20100	-9.78e-02	-0.175000	5.58e-01	2.93e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	3.90e-01	5.98e-01	0.20100	3.31e-02	0.198000	8.19e-01	1.71e-01
Cargo concentration in the ER	32	9.38e-02	2.47e-01	0.20000	-8.04e-02	0.184000	4.31e-01	7.21e-02
COPII-mediated vesicle transport	66	1.33e-02	5.90e-02	0.20000	-1.57e-02	0.200000	8.25e-01	5.01e-03
CD28 dependent Vav1 pathway	11	4.69e-01	6.71e-01	0.20000	1.96e-01	-0.039900	2.60e-01	8.19e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	5.04e-01	6.95e-01	0.20000	1.32e-01	0.150000	3.92e-01	3.32e-01
Mucopolysaccharidoses	10	5.20e-01	7.04e-01	0.20000	-1.99e-01	0.017600	2.76e-01	9.23e-01
Transcriptional Regulation by VENTX	41	7.53e-02	2.13e-01	0.20000	-1.60e-03	0.200000	9.86e-01	2.70e-02
Polymerase switching on the C-strand of the telomere	24	2.52e-01	4.66e-01	0.19900	3.81e-02	0.196000	7.47e-01	9.72e-02
Synthesis of PIPs at the plasma membrane	48	3.87e-02	1.34e-01	0.19900	-1.95e-01	0.038700	1.94e-02	6.43e-01
Cellular Senescence	130	6.89e-04	5.30e-03	0.19800	4.29e-02	0.194000	3.99e-01	1.36e-04
STING mediated induction of host immune responses	13	5.02e-01	6.93e-01	0.19800	1.86e-01	0.069200	2.46e-01	6.66e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	7.23e-02	2.08e-01	0.19800	6.12e-02	0.188000	4.58e-01	2.26e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	5.01e-01	6.92e-01	0.19800	1.03e-01	0.169000	5.03e-01	2.74e-01
Signaling by BMP	27	1.93e-01	3.90e-01	0.19800	-4.85e-03	-0.198000	9.65e-01	7.55e-02
Defensins	36	7.04e-02	2.05e-01	0.19800	1.71e-01	-0.099000	7.57e-02	3.04e-01
SUMOylation	164	6.37e-05	5.93e-04	0.19800	1.70e-02	0.197000	7.07e-01	1.35e-05
Glycolysis	68	2.44e-02	9.41e-02	0.19800	5.09e-02	0.191000	4.68e-01	6.48e-03
Receptor-type tyrosine-protein phosphatases	16	4.10e-01	6.16e-01	0.19800	-4.24e-02	-0.193000	7.69e-01	1.82e-01
Interleukin-6 signaling	11	4.83e-01	6.78e-01	0.19700	3.43e-02	-0.194000	8.44e-01	2.65e-01
Erythropoietin activates RAS	14	3.54e-01	5.69e-01	0.19600	-1.22e-01	0.154000	4.29e-01	3.19e-01
MAPK targets/ Nuclear events mediated by MAP kinases	29	1.85e-01	3.81e-01	0.19600	1.84e-02	0.195000	8.63e-01	6.87e-02
DCC mediated attractive signaling	14	5.16e-01	7.04e-01	0.19600	-1.20e-01	-0.155000	4.38e-01	3.15e-01
Peroxisomal protein import	62	5.40e-02	1.69e-01	0.19600	1.52e-01	0.123000	3.83e-02	9.32e-02
Ub-specific processing proteases	153	7.43e-04	5.61e-03	0.19600	1.18e-01	0.156000	1.15e-02	8.72e-04
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21	3.06e-01	5.21e-01	0.19600	1.93e-01	0.029100	1.25e-01	8.18e-01
Signaling by NTRK1 (TRKA)	114	2.27e-03	1.45e-02	0.19600	5.02e-02	0.189000	3.54e-01	4.89e-04
Acyl chain remodelling of PG	18	2.81e-01	5.01e-01	0.19500	8.11e-02	-0.178000	5.51e-01	1.92e-01
Cytoprotection by HMOX1	58	5.33e-02	1.69e-01	0.19500	7.39e-02	0.181000	3.30e-01	1.73e-02
G2/M DNA damage checkpoint	58	4.94e-02	1.62e-01	0.19500	6.16e-02	0.185000	4.17e-01	1.48e-02
NOTCH1 Intracellular Domain Regulates Transcription	44	8.67e-02	2.36e-01	0.19500	3.23e-02	0.192000	7.11e-01	2.73e-02
Activation of the pre-replicative complex	31	1.89e-01	3.83e-01	0.19500	4.60e-02	0.189000	6.57e-01	6.78e-02
PTEN Regulation	150	2.06e-04	1.73e-03	0.19400	2.07e-02	0.193000	6.61e-01	4.32e-05
Signaling by NOTCH2	32	2.09e-01	4.05e-01	0.19400	1.74e-01	0.086300	8.81e-02	3.98e-01
HDR through Homologous Recombination (HRR)	64	5.15e-02	1.66e-01	0.19400	1.22e-01	0.151000	9.22e-02	3.62e-02
Formation of Fibrin Clot (Clotting Cascade)	37	1.82e-01	3.80e-01	0.19400	-1.43e-01	-0.131000	1.31e-01	1.69e-01
Diseases of DNA repair	49	1.02e-01	2.63e-01	0.19400	1.13e-01	0.158000	1.71e-01	5.62e-02
Dual Incision in GG-NER	39	1.66e-01	3.61e-01	0.19300	1.23e-01	0.149000	1.84e-01	1.06e-01
Ovarian tumor domain proteases	36	1.22e-01	2.98e-01	0.19300	4.80e-03	0.193000	9.60e-01	4.46e-02
MyD88-independent TLR4 cascade	103	4.47e-03	2.53e-02	0.19300	4.68e-02	0.187000	4.11e-01	1.01e-03
TRIF(TICAM1)-mediated TLR4 signaling	103	4.47e-03	2.53e-02	0.19300	4.68e-02	0.187000	4.11e-01	1.01e-03
Nephrin family interactions	21	3.81e-01	5.92e-01	0.19300	-1.21e-01	-0.151000	3.37e-01	2.32e-01
Leading Strand Synthesis	13	5.55e-01	7.34e-01	0.19200	1.28e-01	0.144000	4.25e-01	3.70e-01
Polymerase switching	13	5.55e-01	7.34e-01	0.19200	1.28e-01	0.144000	4.25e-01	3.70e-01
Biosynthesis of DHA-derived SPMs	17	3.00e-01	5.17e-01	0.19200	-1.16e-01	0.153000	4.06e-01	2.76e-01
Chromosome Maintenance	86	1.43e-02	6.22e-02	0.19200	6.70e-02	0.180000	2.83e-01	3.95e-03
RHO GTPases activate IQGAPs	11	5.21e-01	7.04e-01	0.19100	-1.90e-01	0.014900	2.75e-01	9.32e-01
DNA Damage/Telomere Stress Induced Senescence	28	2.15e-01	4.13e-01	0.19000	1.62e-02	0.190000	8.82e-01	8.25e-02
FGFR3 ligand binding and activation	12	5.78e-01	7.47e-01	0.19000	9.77e-02	0.163000	5.58e-01	3.28e-01
FGFR3c ligand binding and activation	12	5.78e-01	7.47e-01	0.19000	9.77e-02	0.163000	5.58e-01	3.28e-01
Formation of Incision Complex in GG-NER	40	1.62e-01	3.54e-01	0.19000	9.93e-02	0.162000	2.77e-01	7.60e-02
Termination of translesion DNA synthesis	31	2.52e-01	4.66e-01	0.19000	1.16e-01	0.150000	2.63e-01	1.48e-01
SUMO E3 ligases SUMOylate target proteins	158	1.79e-04	1.54e-03	0.18900	1.10e-02	0.189000	8.12e-01	4.24e-05
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14	4.09e-01	6.16e-01	0.18900	5.91e-02	-0.179000	7.02e-01	2.46e-01
Mitotic Spindle Checkpoint	106	6.87e-03	3.57e-02	0.18900	7.30e-02	0.174000	1.94e-01	1.96e-03
FGFR2b ligand binding and activation	10	5.19e-01	7.04e-01	0.18900	1.73e-01	-0.075800	3.44e-01	6.78e-01
RNA Polymerase I Promoter Escape	28	2.96e-01	5.16e-01	0.18900	1.37e-01	0.129000	2.09e-01	2.36e-01
Signaling by ALK fusions and activated point mutants	51	4.20e-02	1.42e-01	0.18800	-4.78e-02	0.182000	5.55e-01	2.44e-02
Signaling by ALK in cancer	51	4.20e-02	1.42e-01	0.18800	-4.78e-02	0.182000	5.55e-01	2.44e-02
Eicosanoid ligand-binding receptors	14	3.83e-01	5.94e-01	0.18800	-1.29e-01	0.137000	4.03e-01	3.75e-01
Signaling by FGFR4 in disease	11	5.90e-01	7.54e-01	0.18800	-1.77e-01	-0.063200	3.09e-01	7.17e-01
Telomere Maintenance	62	6.26e-02	1.89e-01	0.18800	9.55e-02	0.162000	1.93e-01	2.74e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	3.76e-02	1.31e-01	0.18800	-6.96e-02	0.175000	3.90e-01	3.10e-02
Response to metal ions	14	5.12e-01	7.00e-01	0.18800	6.20e-02	0.177000	6.88e-01	2.51e-01
Metabolism of amino acids and derivatives	344	2.78e-07	4.88e-06	0.18800	1.60e-01	0.097800	3.22e-07	1.81e-03
Signaling by FLT3 ITD and TKD mutants	16	4.31e-01	6.36e-01	0.18700	2.21e-02	0.186000	8.79e-01	1.97e-01
Integrin signaling	27	1.87e-01	3.82e-01	0.18700	-1.80e-01	0.053000	1.06e-01	6.34e-01
Dissolution of Fibrin Clot	13	5.72e-01	7.43e-01	0.18700	1.22e-01	0.142000	4.47e-01	3.75e-01
FLT3 signaling in disease	28	2.51e-01	4.66e-01	0.18700	4.60e-02	0.181000	6.73e-01	9.65e-02
Citric acid cycle (TCA cycle)	21	4.09e-01	6.16e-01	0.18600	1.25e-01	0.139000	3.23e-01	2.71e-01
Signaling by FGFR4	40	1.62e-01	3.54e-01	0.18600	7.54e-02	0.170000	4.09e-01	6.24e-02
O-linked glycosylation of mucins	62	5.73e-02	1.77e-01	0.18600	-1.73e-01	-0.068100	1.84e-02	3.53e-01
Triglyceride biosynthesis	13	4.28e-01	6.33e-01	0.18600	9.38e-02	-0.160000	5.58e-01	3.16e-01
Zinc transporters	17	4.88e-01	6.83e-01	0.18600	1.27e-01	0.135000	3.64e-01	3.34e-01
Gap junction assembly	18	3.14e-01	5.31e-01	0.18600	8.42e-02	-0.165000	5.36e-01	2.25e-01
Uptake and function of anthrax toxins	11	6.28e-01	7.88e-01	0.18500	-1.19e-01	-0.142000	4.94e-01	4.14e-01
DNA Double-Strand Break Repair	129	4.23e-03	2.42e-02	0.18500	1.10e-01	0.149000	3.10e-02	3.42e-03
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	3.59e-01	5.73e-01	0.18500	1.75e-01	0.060200	1.55e-01	6.25e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	6.21e-01	7.81e-01	0.18500	9.42e-02	0.159000	5.88e-01	3.60e-01
Insulin processing	26	3.37e-01	5.52e-01	0.18500	-1.37e-01	-0.125000	2.28e-01	2.71e-01
Platelet sensitization by LDL	17	3.53e-01	5.69e-01	0.18400	-6.21e-02	0.173000	6.57e-01	2.16e-01
Regulation of NPAS4 gene expression	13	5.83e-01	7.49e-01	0.18400	-1.20e-01	-0.139000	4.53e-01	3.84e-01
Signaling by FGFR	85	3.04e-02	1.12e-01	0.18300	1.24e-01	0.135000	4.79e-02	3.12e-02
Regulation of beta-cell development	41	1.82e-01	3.80e-01	0.18300	1.10e-01	0.147000	2.22e-01	1.04e-01
Glutathione synthesis and recycling	12	5.24e-01	7.07e-01	0.18300	-5.69e-03	0.183000	9.73e-01	2.72e-01
Transcriptional regulation of white adipocyte differentiation	81	3.13e-02	1.15e-01	0.18300	8.83e-02	0.160000	1.69e-01	1.25e-02
RHOV GTPase cycle	36	1.50e-01	3.39e-01	0.18300	-1.83e-01	-0.001430	5.74e-02	9.88e-01
ABC-family proteins mediated transport	98	1.57e-02	6.71e-02	0.18300	1.58e-01	0.091400	6.72e-03	1.18e-01
Beta-oxidation of very long chain fatty acids	10	5.63e-01	7.39e-01	0.18300	-3.68e-02	0.179000	8.40e-01	3.27e-01
Mitotic Telophase/Cytokinesis	10	5.25e-01	7.07e-01	0.18300	-1.37e-01	0.120000	4.53e-01	5.09e-01
RNA Polymerase I Transcription Initiation	42	1.63e-01	3.56e-01	0.18200	7.95e-02	0.164000	3.72e-01	6.56e-02
Phospholipase C-mediated cascade; FGFR2	17	5.01e-01	6.92e-01	0.18200	1.24e-01	0.134000	3.76e-01	3.40e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	20	4.20e-01	6.25e-01	0.18200	-7.68e-02	-0.165000	5.52e-01	2.01e-01
HDR through Single Strand Annealing (SSA)	36	2.22e-01	4.24e-01	0.18200	9.15e-02	0.157000	3.42e-01	1.03e-01
HCMV Early Events	55	7.79e-02	2.17e-01	0.18100	4.15e-02	0.176000	5.94e-01	2.39e-02
FRS-mediated FGFR3 signaling	19	3.79e-01	5.90e-01	0.18100	4.23e-03	0.181000	9.75e-01	1.73e-01
Synthesis of PA	35	2.08e-01	4.04e-01	0.18000	-4.90e-02	-0.173000	6.16e-01	7.70e-02
Prefoldin mediated transfer of substrate to CCT/TriC	27	3.15e-01	5.31e-01	0.17900	1.66e-01	0.065800	1.34e-01	5.54e-01
Synthesis of PIPs at the early endosome membrane	15	4.50e-01	6.57e-01	0.17800	-1.77e-01	0.024000	2.36e-01	8.72e-01
SHC-mediated cascade:FGFR2	22	3.42e-01	5.59e-01	0.17800	1.17e-02	0.178000	9.25e-01	1.48e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	2.53e-01	4.66e-01	0.17800	3.51e-02	0.175000	7.39e-01	9.75e-02
Regulation of TP53 Activity through Acetylation	29	1.95e-01	3.94e-01	0.17800	-5.15e-02	0.170000	6.31e-01	1.12e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	2.51e-01	4.66e-01	0.17700	1.31e-01	0.119000	1.75e-01	2.15e-01
Maturation of spike protein 9694548	35	1.28e-01	3.08e-01	0.17600	-8.89e-02	0.152000	3.63e-01	1.19e-01
Regulation of TP53 Activity	154	1.62e-03	1.10e-02	0.17600	6.08e-02	0.166000	1.93e-01	3.88e-04
NOTCH2 intracellular domain regulates transcription	11	6.55e-01	8.02e-01	0.17600	1.42e-01	0.105000	4.16e-01	5.48e-01
Heme signaling	45	1.43e-01	3.31e-01	0.17600	-1.70e-01	-0.046900	4.89e-02	5.86e-01
Aggrephagy	23	3.67e-01	5.81e-01	0.17600	1.70e-01	0.044000	1.57e-01	7.15e-01
O-linked glycosylation	107	1.75e-02	7.34e-02	0.17600	-1.33e-01	-0.115000	1.71e-02	4.03e-02
Signaling by NTRKs	133	3.49e-03	2.08e-02	0.17500	4.74e-02	0.169000	3.45e-01	7.83e-04
RHOU GTPase cycle	37	1.54e-01	3.43e-01	0.17500	-1.73e-01	0.020300	6.78e-02	8.31e-01
Interleukin-35 Signalling	12	5.37e-01	7.19e-01	0.17400	3.05e-02	-0.172000	8.55e-01	3.03e-01
Gene expression (Transcription)	1420	2.57e-24	7.94e-22	0.17400	6.47e-02	0.162000	3.99e-05	1.09e-24
RHOQ GTPase cycle	57	8.22e-02	2.28e-01	0.17400	-1.71e-01	-0.032200	2.55e-02	6.74e-01
Interleukin-2 signaling	11	5.45e-01	7.24e-01	0.17400	1.61e-01	-0.064900	3.54e-01	7.09e-01
RNA Polymerase II Transcription	1284	9.70e-22	2.50e-19	0.17400	7.26e-02	0.158000	1.13e-05	1.12e-21
Antimicrobial peptides	78	1.24e-02	5.58e-02	0.17400	1.55e-01	-0.078500	1.79e-02	2.31e-01
Diseases associated with visual transduction	11	6.65e-01	8.07e-01	0.17400	-1.33e-01	-0.111000	4.45e-01	5.22e-01
Diseases of the neuronal system	11	6.65e-01	8.07e-01	0.17400	-1.33e-01	-0.111000	4.45e-01	5.22e-01
Retinoid cycle disease events	11	6.65e-01	8.07e-01	0.17400	-1.33e-01	-0.111000	4.45e-01	5.22e-01
APC truncation mutants have impaired AXIN binding	13	4.93e-01	6.85e-01	0.17300	-5.98e-02	0.163000	7.09e-01	3.10e-01
AXIN missense mutants destabilize the destruction complex	13	4.93e-01	6.85e-01	0.17300	-5.98e-02	0.163000	7.09e-01	3.10e-01
Signaling by AMER1 mutants	13	4.93e-01	6.85e-01	0.17300	-5.98e-02	0.163000	7.09e-01	3.10e-01
Signaling by APC mutants	13	4.93e-01	6.85e-01	0.17300	-5.98e-02	0.163000	7.09e-01	3.10e-01
Signaling by AXIN mutants	13	4.93e-01	6.85e-01	0.17300	-5.98e-02	0.163000	7.09e-01	3.10e-01
Truncations of AMER1 destabilize the destruction complex	13	4.93e-01	6.85e-01	0.17300	-5.98e-02	0.163000	7.09e-01	3.10e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	5.64e-02	1.75e-01	0.17300	7.37e-02	0.156000	2.73e-01	2.01e-02
Processive synthesis on the lagging strand	14	5.87e-01	7.52e-01	0.17200	8.17e-02	0.152000	5.97e-01	3.25e-01
GRB2 events in ERBB2 signaling	16	4.71e-01	6.72e-01	0.17200	-1.72e-01	0.000783	2.32e-01	9.96e-01
TCF dependent signaling in response to WNT	168	1.90e-03	1.24e-02	0.17200	8.82e-02	0.148000	4.84e-02	9.38e-04
ERBB2 Activates PTK6 Signaling	13	5.59e-01	7.37e-01	0.17200	-1.65e-02	-0.171000	9.18e-01	2.85e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	4.12e-01	6.18e-01	0.17200	-1.00e-04	0.172000	9.99e-01	1.95e-01
Acyl chain remodelling of PC	26	2.64e-01	4.78e-01	0.17200	4.01e-02	-0.167000	7.24e-01	1.41e-01
Thrombin signalling through proteinase activated receptors (PARs)	32	1.78e-01	3.76e-01	0.17100	-6.65e-02	0.158000	5.15e-01	1.22e-01
Signaling by Hedgehog	133	8.67e-03	4.23e-02	0.17100	1.15e-01	0.126000	2.16e-02	1.18e-02
Acyl chain remodelling of PS	21	3.81e-01	5.92e-01	0.17000	6.00e-04	-0.170000	9.96e-01	1.76e-01
Signaling by the B Cell Receptor (BCR)	105	2.44e-02	9.41e-02	0.17000	1.21e-01	0.120000	3.26e-02	3.32e-02
Extracellular matrix organization	287	4.48e-05	4.36e-04	0.17000	-1.19e-01	-0.121000	5.09e-04	4.16e-04
CTNNB1 S33 mutants aren’t phosphorylated	14	4.62e-01	6.68e-01	0.16900	-1.06e-01	0.131000	4.91e-01	3.94e-01
CTNNB1 S37 mutants aren’t phosphorylated	14	4.62e-01	6.68e-01	0.16900	-1.06e-01	0.131000	4.91e-01	3.94e-01
CTNNB1 S45 mutants aren’t phosphorylated	14	4.62e-01	6.68e-01	0.16900	-1.06e-01	0.131000	4.91e-01	3.94e-01
CTNNB1 T41 mutants aren’t phosphorylated	14	4.62e-01	6.68e-01	0.16900	-1.06e-01	0.131000	4.91e-01	3.94e-01
Signaling by CTNNB1 phospho-site mutants	14	4.62e-01	6.68e-01	0.16900	-1.06e-01	0.131000	4.91e-01	3.94e-01
Signaling by GSK3beta mutants	14	4.62e-01	6.68e-01	0.16900	-1.06e-01	0.131000	4.91e-01	3.94e-01
TRP channels	24	3.60e-01	5.74e-01	0.16900	-2.09e-02	-0.168000	8.60e-01	1.55e-01
Activated point mutants of FGFR2	16	5.72e-01	7.44e-01	0.16900	1.18e-01	0.120000	4.12e-01	4.04e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	27	2.82e-01	5.02e-01	0.16900	1.59e-02	-0.168000	8.86e-01	1.31e-01
Activated NOTCH1 Transmits Signal to the Nucleus	30	2.37e-01	4.46e-01	0.16900	1.67e-01	-0.026100	1.14e-01	8.04e-01
Mitochondrial biogenesis	69	6.59e-02	1.96e-01	0.16900	4.67e-02	0.162000	5.02e-01	2.00e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	4.42e-01	6.50e-01	0.16800	-1.30e-01	0.106000	3.84e-01	4.76e-01
Infectious disease	830	3.74e-13	1.84e-11	0.16800	8.67e-02	0.144000	2.07e-05	1.77e-12
Ethanol oxidation	12	5.41e-01	7.22e-01	0.16700	6.23e-02	-0.155000	7.08e-01	3.51e-01
Generic Transcription Pathway	1163	1.59e-18	2.04e-16	0.16700	6.69e-02	0.153000	1.12e-04	8.91e-19
Assembly of collagen fibrils and other multimeric structures	56	1.12e-01	2.82e-01	0.16700	-4.34e-02	-0.161000	5.74e-01	3.66e-02
Metabolism of nucleotides	95	1.26e-02	5.64e-02	0.16700	-1.79e-02	0.166000	7.63e-01	5.15e-03
ECM proteoglycans	55	1.53e-01	3.43e-01	0.16700	-1.08e-01	-0.127000	1.67e-01	1.02e-01
SHC-mediated cascade:FGFR4	19	4.06e-01	6.14e-01	0.16700	-3.06e-02	0.164000	8.18e-01	2.16e-01
Meiotic synapsis	32	1.86e-01	3.81e-01	0.16600	-1.42e-01	0.087500	1.66e-01	3.92e-01
SARS-CoV-2-host interactions	183	1.48e-03	1.01e-02	0.16600	7.19e-02	0.150000	9.32e-02	4.80e-04
Signaling by PDGFRA extracellular domain mutants	12	5.59e-01	7.37e-01	0.16600	-1.59e-01	0.045200	3.39e-01	7.86e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	5.59e-01	7.37e-01	0.16600	-1.59e-01	0.045200	3.39e-01	7.86e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	38	1.82e-01	3.80e-01	0.16500	-1.65e-01	0.014000	7.85e-02	8.81e-01
Downstream signaling of activated FGFR3	24	3.72e-01	5.85e-01	0.16500	1.65e-02	0.164000	8.89e-01	1.63e-01
RHOBTB2 GTPase cycle	22	4.74e-01	6.74e-01	0.16500	1.35e-01	0.095900	2.75e-01	4.36e-01
Acyl chain remodelling of PE	24	3.12e-01	5.29e-01	0.16500	4.82e-02	-0.158000	6.83e-01	1.80e-01
Nicotinamide salvaging	17	4.20e-01	6.25e-01	0.16500	7.69e-02	-0.146000	5.83e-01	2.97e-01
Creation of C4 and C2 activators	14	5.96e-01	7.59e-01	0.16500	-5.41e-02	-0.156000	7.26e-01	3.13e-01
Activation of Matrix Metalloproteinases	31	3.28e-01	5.45e-01	0.16500	-6.43e-02	-0.152000	5.36e-01	1.44e-01
Impaired BRCA2 binding to RAD51	33	3.29e-01	5.45e-01	0.16500	9.63e-02	0.134000	3.39e-01	1.84e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	75	4.76e-02	1.57e-01	0.16400	1.59e-02	0.163000	8.11e-01	1.44e-02
Deubiquitination	226	4.98e-04	3.91e-03	0.16400	8.43e-02	0.140000	2.88e-02	2.73e-04
mRNA decay by 5’ to 3’ exoribonuclease	15	5.67e-01	7.43e-01	0.16400	3.95e-02	0.159000	7.91e-01	2.87e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	31	3.49e-01	5.65e-01	0.16300	8.01e-02	0.142000	4.40e-01	1.71e-01
Non-integrin membrane-ECM interactions	40	2.63e-01	4.78e-01	0.16300	-1.38e-01	-0.087500	1.32e-01	3.38e-01
Signaling by NODAL	21	3.91e-01	6.00e-01	0.16200	1.60e-01	-0.026600	2.04e-01	8.33e-01
Maturation of nucleoprotein 9694631	15	4.70e-01	6.71e-01	0.16200	9.18e-02	-0.134000	5.38e-01	3.69e-01
Downstream signaling of activated FGFR1	31	3.43e-01	5.59e-01	0.16200	6.64e-02	0.148000	5.22e-01	1.54e-01
MAP2K and MAPK activation	36	1.87e-01	3.82e-01	0.16200	-4.71e-02	0.155000	6.25e-01	1.08e-01
CS/DS degradation	12	5.46e-01	7.25e-01	0.16200	-1.01e-01	0.127000	5.46e-01	4.48e-01
Potential therapeutics for SARS	92	1.95e-02	7.99e-02	0.16200	-1.44e-02	0.161000	8.12e-01	7.59e-03
Regulation of FZD by ubiquitination	21	5.11e-01	7.00e-01	0.16200	1.09e-01	0.119000	3.87e-01	3.44e-01
Negative regulation of MET activity	20	4.40e-01	6.48e-01	0.16200	1.78e-03	0.162000	9.89e-01	2.11e-01
Reversible hydration of carbon dioxide	11	7.04e-01	8.35e-01	0.16200	1.12e-01	0.117000	5.22e-01	5.02e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	2.90e-01	5.09e-01	0.16100	1.21e-01	0.106000	1.90e-01	2.53e-01
Diseases of DNA Double-Strand Break Repair	39	2.90e-01	5.09e-01	0.16100	1.21e-01	0.106000	1.90e-01	2.53e-01
NPAS4 regulates expression of target genes	21	4.81e-01	6.78e-01	0.16100	1.51e-01	0.054400	2.31e-01	6.66e-01
Rab regulation of trafficking	113	6.12e-03	3.33e-02	0.16000	-4.17e-02	0.155000	4.44e-01	4.42e-03
Translesion synthesis by REV1	16	6.03e-01	7.64e-01	0.16000	1.02e-01	0.124000	4.80e-01	3.91e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	23	4.84e-01	6.78e-01	0.16000	1.22e-01	0.104000	3.11e-01	3.88e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	23	4.84e-01	6.78e-01	0.16000	1.22e-01	0.104000	3.11e-01	3.88e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	23	4.84e-01	6.78e-01	0.16000	1.22e-01	0.104000	3.11e-01	3.88e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	23	4.84e-01	6.78e-01	0.16000	1.22e-01	0.104000	3.11e-01	3.88e-01
Impaired BRCA2 binding to PALB2	23	4.84e-01	6.78e-01	0.16000	1.22e-01	0.104000	3.11e-01	3.88e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	35	2.89e-01	5.09e-01	0.16000	4.46e-02	0.154000	6.48e-01	1.16e-01
Butyrophilin (BTN) family interactions	12	6.30e-01	7.89e-01	0.16000	1.59e-01	0.015900	3.40e-01	9.24e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	14	6.35e-01	7.92e-01	0.15900	-1.39e-01	-0.077700	3.68e-01	6.15e-01
Diseases of hemostasis	14	6.35e-01	7.92e-01	0.15900	-1.39e-01	-0.077700	3.68e-01	6.15e-01
NCAM1 interactions	36	1.73e-01	3.70e-01	0.15900	1.24e-01	-0.099500	1.98e-01	3.01e-01
Translesion synthesis by POLI	17	5.77e-01	7.47e-01	0.15900	1.40e-01	0.075800	3.18e-01	5.88e-01
FGFR1 mutant receptor activation	30	3.62e-01	5.76e-01	0.15900	5.73e-02	0.148000	5.87e-01	1.60e-01
RHOB GTPase cycle	66	9.65e-02	2.52e-01	0.15900	-1.54e-01	-0.040300	3.07e-02	5.71e-01
LGI-ADAM interactions	14	6.15e-01	7.74e-01	0.15900	4.63e-02	0.152000	7.64e-01	3.25e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	32	3.74e-01	5.85e-01	0.15800	1.09e-01	0.115000	2.85e-01	2.61e-01
Programmed Cell Death	192	2.48e-03	1.56e-02	0.15800	8.54e-02	0.133000	4.10e-02	1.44e-03
Telomere C-strand (Lagging Strand) Synthesis	32	2.81e-01	5.01e-01	0.15800	-1.82e-03	0.158000	9.86e-01	1.22e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	1.84e-01	3.80e-01	0.15700	8.00e-02	0.136000	3.09e-01	8.49e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	1.84e-01	3.80e-01	0.15700	8.00e-02	0.136000	3.09e-01	8.49e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	1.84e-01	3.80e-01	0.15700	8.00e-02	0.136000	3.09e-01	8.49e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	1.84e-01	3.80e-01	0.15700	8.00e-02	0.136000	3.09e-01	8.49e-02
Signaling by NOTCH1 in Cancer	54	1.84e-01	3.80e-01	0.15700	8.00e-02	0.136000	3.09e-01	8.49e-02
Early SARS-CoV-2 Infection Events	34	2.68e-01	4.83e-01	0.15700	3.07e-03	0.157000	9.75e-01	1.12e-01
Glutathione conjugation	36	2.37e-01	4.46e-01	0.15700	-1.00e-02	0.157000	9.17e-01	1.04e-01
RHOH GTPase cycle	36	1.85e-01	3.81e-01	0.15700	-8.45e-02	0.132000	3.80e-01	1.70e-01
Cell junction organization	79	8.88e-02	2.37e-01	0.15700	-8.80e-02	-0.130000	1.76e-01	4.59e-02
PI Metabolism	79	2.96e-02	1.10e-01	0.15600	-1.44e-01	0.060500	2.71e-02	3.52e-01
Retrograde neurotrophin signalling	14	6.59e-01	8.03e-01	0.15600	1.03e-01	0.117000	5.03e-01	4.49e-01
Removal of the Flap Intermediate	13	6.81e-01	8.20e-01	0.15500	1.03e-01	0.116000	5.19e-01	4.69e-01
Extension of Telomeres	48	1.89e-01	3.83e-01	0.15500	3.00e-02	0.152000	7.19e-01	6.79e-02
Apoptosis	164	7.94e-03	3.97e-02	0.15500	9.35e-02	0.123000	3.88e-02	6.33e-03
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	106	1.77e-02	7.34e-02	0.15500	-3.97e-03	0.155000	9.44e-01	5.94e-03
Toll Like Receptor 2 (TLR2) Cascade	106	1.77e-02	7.34e-02	0.15500	-3.97e-03	0.155000	9.44e-01	5.94e-03
Toll Like Receptor TLR1:TLR2 Cascade	106	1.77e-02	7.34e-02	0.15500	-3.97e-03	0.155000	9.44e-01	5.94e-03
Toll Like Receptor TLR6:TLR2 Cascade	106	1.77e-02	7.34e-02	0.15500	-3.97e-03	0.155000	9.44e-01	5.94e-03
Transcriptional activation of mitochondrial biogenesis	51	2.12e-01	4.08e-01	0.15500	7.57e-02	0.135000	3.50e-01	9.57e-02
SUMOylation of transcription cofactors	43	1.96e-01	3.94e-01	0.15500	-2.09e-03	0.155000	9.81e-01	7.95e-02
Telomere Extension By Telomerase	22	4.69e-01	6.71e-01	0.15400	2.99e-02	0.152000	8.08e-01	2.18e-01
Homologous DNA Pairing and Strand Exchange	41	3.03e-01	5.18e-01	0.15400	1.08e-01	0.111000	2.33e-01	2.20e-01
Regulation of Complement cascade	45	2.70e-01	4.86e-01	0.15400	-9.68e-02	-0.120000	2.61e-01	1.65e-01
tRNA modification in the nucleus and cytosol	38	3.24e-01	5.42e-01	0.15400	8.42e-02	0.129000	3.69e-01	1.70e-01
NR1H2 and NR1H3-mediated signaling	53	2.00e-01	3.99e-01	0.15400	-1.36e-01	-0.071000	8.60e-02	3.71e-01
Regulation of TP53 Expression and Degradation	37	3.23e-01	5.41e-01	0.15300	6.69e-02	0.138000	4.81e-01	1.46e-01
Signaling by NTRK3 (TRKC)	17	4.72e-01	6.73e-01	0.15300	-7.27e-02	0.135000	6.04e-01	3.35e-01
Asparagine N-linked glycosylation	278	1.15e-04	1.03e-03	0.15300	3.70e-02	0.148000	2.87e-01	2.07e-05
Signaling by FGFR2 in disease	42	3.02e-01	5.18e-01	0.15300	1.03e-01	0.113000	2.48e-01	2.06e-01
Sphingolipid de novo biosynthesis	41	2.32e-01	4.39e-01	0.15300	-1.52e-01	-0.010300	9.13e-02	9.09e-01
G-protein activation	24	3.41e-01	5.58e-01	0.15200	-1.09e-01	0.106000	3.55e-01	3.68e-01
MASTL Facilitates Mitotic Progression	10	6.49e-01	8.01e-01	0.15100	-7.61e-02	0.131000	6.77e-01	4.74e-01
Stimuli-sensing channels	96	6.73e-02	1.98e-01	0.15100	-9.24e-02	-0.120000	1.17e-01	4.28e-02
Cell-extracellular matrix interactions	14	6.33e-01	7.91e-01	0.15100	1.48e-01	0.031400	3.39e-01	8.39e-01
Toll Like Receptor 4 (TLR4) Cascade	135	8.28e-03	4.08e-02	0.15100	3.09e-03	0.151000	9.51e-01	2.45e-03
Synthesis of substrates in N-glycan biosythesis	60	1.75e-01	3.73e-01	0.15100	7.37e-02	0.132000	3.23e-01	7.75e-02
Regulation of commissural axon pathfinding by SLIT and ROBO	10	7.57e-01	8.65e-01	0.15100	-1.08e-01	-0.105000	5.53e-01	5.65e-01
Signaling by NOTCH	182	6.19e-03	3.34e-02	0.15100	8.92e-02	0.121000	3.77e-02	4.73e-03
Glucose metabolism	87	6.83e-02	2.00e-01	0.15100	4.81e-02	0.143000	4.38e-01	2.13e-02
Glycosphingolipid metabolism	40	2.91e-01	5.10e-01	0.15000	4.76e-02	0.143000	6.02e-01	1.18e-01
SARS-CoV Infections	387	5.81e-06	7.08e-05	0.15000	3.98e-02	0.145000	1.78e-01	9.38e-07
Gap junction trafficking	27	4.03e-01	6.11e-01	0.15000	-1.87e-02	-0.149000	8.66e-01	1.80e-01
Organic cation transport	10	6.72e-01	8.11e-01	0.15000	-4.09e-02	0.144000	8.23e-01	4.30e-01
ALK mutants bind TKIs	12	6.45e-01	8.00e-01	0.15000	-1.49e-01	0.010500	3.70e-01	9.50e-01
Signalling to ERKs	34	2.40e-01	4.51e-01	0.15000	-7.01e-02	0.132000	4.79e-01	1.82e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	5.06e-01	6.97e-01	0.14900	1.04e-01	0.107000	3.69e-01	3.54e-01
Regulation of TP53 Degradation	36	3.34e-01	5.50e-01	0.14900	4.57e-02	0.142000	6.35e-01	1.41e-01
Visual phototransduction	93	5.28e-02	1.68e-01	0.14900	-3.21e-02	-0.145000	5.93e-01	1.53e-02
Toll Like Receptor 9 (TLR9) Cascade	100	3.90e-02	1.34e-01	0.14900	2.36e-02	0.147000	6.83e-01	1.10e-02
VEGFA-VEGFR2 Pathway	93	2.27e-02	8.93e-02	0.14900	-1.35e-01	0.062000	2.44e-02	3.01e-01
Presynaptic phase of homologous DNA pairing and strand exchange	38	3.55e-01	5.71e-01	0.14800	8.92e-02	0.119000	3.41e-01	2.05e-01
Platelet Aggregation (Plug Formation)	37	2.26e-01	4.31e-01	0.14800	-1.37e-01	0.056400	1.49e-01	5.53e-01
Degradation of the extracellular matrix	108	5.16e-02	1.66e-01	0.14800	-7.91e-02	-0.125000	1.55e-01	2.46e-02
MyD88 dependent cascade initiated on endosome	96	5.04e-02	1.64e-01	0.14700	3.03e-02	0.144000	6.08e-01	1.45e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade	96	5.04e-02	1.64e-01	0.14700	3.03e-02	0.144000	6.08e-01	1.45e-02
Vitamin B5 (pantothenate) metabolism	16	6.50e-01	8.01e-01	0.14700	8.69e-02	0.119000	5.47e-01	4.10e-01
Interleukin-1 family signaling	145	2.21e-02	8.76e-02	0.14700	1.05e-01	0.103000	2.93e-02	3.22e-02
InlB-mediated entry of Listeria monocytogenes into host cell	14	6.90e-01	8.28e-01	0.14700	1.15e-01	0.090700	4.56e-01	5.57e-01
G beta:gamma signalling through PI3Kgamma	25	3.71e-01	5.84e-01	0.14700	-1.33e-01	0.060900	2.49e-01	5.98e-01
FCERI mediated MAPK activation	29	3.04e-01	5.19e-01	0.14600	-1.20e-01	0.084500	2.65e-01	4.31e-01
RNA Polymerase III Transcription Termination	23	5.48e-01	7.27e-01	0.14600	1.05e-01	0.102000	3.84e-01	3.98e-01
Fc epsilon receptor (FCERI) signaling	126	3.55e-02	1.26e-01	0.14600	8.23e-02	0.121000	1.11e-01	1.93e-02
Amino acids regulate mTORC1	52	1.30e-01	3.10e-01	0.14600	-5.96e-02	0.133000	4.57e-01	9.68e-02
Activated NTRK2 signals through FRS2 and FRS3	11	6.44e-01	7.99e-01	0.14600	-7.18e-02	0.127000	6.80e-01	4.66e-01
GPVI-mediated activation cascade	32	3.01e-01	5.18e-01	0.14600	-4.07e-02	0.140000	6.90e-01	1.71e-01
Phase II - Conjugation of compounds	106	4.37e-02	1.47e-01	0.14500	-1.41e-01	-0.034800	1.24e-02	5.36e-01
Myogenesis	29	3.28e-01	5.45e-01	0.14500	-1.33e-01	0.057100	2.15e-01	5.94e-01
Interleukin-4 and Interleukin-13 signaling	104	7.18e-02	2.07e-01	0.14400	9.74e-02	0.106000	8.58e-02	6.14e-02
Phenylalanine and tyrosine metabolism	10	7.11e-01	8.39e-01	0.14400	-1.44e-01	0.012500	4.32e-01	9.45e-01
Deactivation of the beta-catenin transactivating complex	39	2.97e-01	5.16e-01	0.14400	1.63e-02	0.143000	8.60e-01	1.22e-01
Metabolism of Angiotensinogen to Angiotensins	15	6.84e-01	8.23e-01	0.14400	-9.61e-02	-0.107000	5.19e-01	4.74e-01
Branched-chain amino acid catabolism	20	5.92e-01	7.56e-01	0.14300	6.88e-02	0.126000	5.94e-01	3.31e-01
Antigen processing: Ubiquitination & Proteasome degradation	293	2.72e-04	2.26e-03	0.14200	3.76e-02	0.137000	2.68e-01	5.18e-05
Reduction of cytosolic Ca++ levels	11	6.70e-01	8.11e-01	0.14200	1.34e-01	-0.047300	4.42e-01	7.86e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	95	6.37e-02	1.92e-01	0.14200	2.80e-02	0.139000	6.37e-01	1.90e-02
Processive synthesis on the C-strand of the telomere	19	4.92e-01	6.85e-01	0.14200	-6.24e-02	0.127000	6.38e-01	3.37e-01
Apoptotic cleavage of cellular proteins	35	2.79e-01	4.98e-01	0.14200	-1.32e-01	0.051100	1.76e-01	6.01e-01
Late endosomal microautophagy	32	4.46e-01	6.54e-01	0.14200	7.47e-02	0.120000	4.64e-01	2.39e-01
Retinoid metabolism and transport	42	2.56e-01	4.71e-01	0.14100	8.49e-03	-0.141000	9.24e-01	1.13e-01
Disorders of transmembrane transporters	167	1.61e-02	6.83e-02	0.14100	1.17e-01	0.079400	9.21e-03	7.64e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	7.26e-01	8.47e-01	0.14100	8.44e-02	0.113000	5.98e-01	4.81e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	89	9.16e-02	2.43e-01	0.14100	4.67e-02	0.133000	4.46e-01	3.01e-02
Amplification of signal from the kinetochores	89	9.16e-02	2.43e-01	0.14100	4.67e-02	0.133000	4.46e-01	3.01e-02
Retrograde transport at the Trans-Golgi-Network	47	2.60e-01	4.74e-01	0.14100	2.62e-02	0.138000	7.56e-01	1.01e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	43	3.15e-01	5.31e-01	0.14100	-1.33e-01	-0.046000	1.31e-01	6.02e-01
Formation of the cornified envelope	73	1.72e-01	3.69e-01	0.14100	-9.74e-02	-0.101000	1.50e-01	1.35e-01
Neurexins and neuroligins	52	2.86e-01	5.05e-01	0.14000	-9.71e-02	-0.102000	2.26e-01	2.05e-01
Signaling by VEGF	101	2.72e-02	1.03e-01	0.14000	-1.31e-01	0.050400	2.29e-02	3.81e-01
G alpha (s) signalling events	153	2.43e-02	9.41e-02	0.14000	-1.14e-01	-0.082100	1.51e-02	7.95e-02
Lagging Strand Synthesis	19	6.17e-01	7.76e-01	0.14000	6.26e-02	0.125000	6.37e-01	3.44e-01
Golgi Associated Vesicle Biogenesis	51	1.44e-01	3.31e-01	0.14000	-9.77e-02	0.100000	2.27e-01	2.15e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	7.17e-01	8.43e-01	0.14000	3.29e-02	0.136000	8.43e-01	4.15e-01
Translesion synthesis by POLK	17	6.54e-01	8.01e-01	0.14000	6.77e-02	0.122000	6.29e-01	3.82e-01
Interferon Signaling	191	1.05e-02	4.88e-02	0.14000	8.96e-02	0.107000	3.27e-02	1.05e-02
Signaling by high-kinase activity BRAF mutants	32	2.99e-01	5.16e-01	0.14000	-9.56e-02	0.102000	3.49e-01	3.18e-01
Complement cascade	56	2.58e-01	4.73e-01	0.14000	-8.13e-02	-0.113000	2.93e-01	1.42e-01
Other semaphorin interactions	18	5.79e-01	7.47e-01	0.13900	-1.39e-01	-0.003970	3.06e-01	9.77e-01
Toll-like Receptor Cascades	154	8.67e-03	4.23e-02	0.13900	-3.47e-03	0.139000	9.41e-01	2.84e-03
Metallothioneins bind metals	11	7.61e-01	8.67e-01	0.13900	6.67e-02	0.122000	7.02e-01	4.83e-01
Downregulation of ERBB2 signaling	28	5.08e-01	6.98e-01	0.13900	1.16e-01	0.077700	2.90e-01	4.77e-01
Trafficking and processing of endosomal TLR	11	7.66e-01	8.69e-01	0.13900	7.85e-02	0.115000	6.52e-01	5.09e-01
Synthesis of PIPs at the Golgi membrane	17	5.41e-01	7.22e-01	0.13900	-1.24e-01	0.062800	3.75e-01	6.54e-01
Elevation of cytosolic Ca2+ levels	16	5.68e-01	7.43e-01	0.13900	-1.29e-01	0.053000	3.73e-01	7.13e-01
Phospholipase C-mediated cascade; FGFR4	14	7.18e-01	8.43e-01	0.13900	9.08e-02	0.105000	5.56e-01	4.96e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	120	2.01e-02	8.18e-02	0.13900	1.37e-01	-0.022800	9.53e-03	6.66e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	7.21e-01	8.44e-01	0.13900	3.30e-02	0.135000	8.43e-01	4.19e-01
alpha-linolenic acid (ALA) metabolism	12	7.21e-01	8.44e-01	0.13900	3.30e-02	0.135000	8.43e-01	4.19e-01
Cell-Cell communication	112	7.22e-02	2.08e-01	0.13900	-1.03e-01	-0.092500	5.87e-02	9.08e-02
Gap junction trafficking and regulation	29	4.65e-01	6.70e-01	0.13900	-4.20e-02	-0.132000	6.95e-01	2.18e-01
MAP kinase activation	58	2.00e-01	3.99e-01	0.13800	2.30e-02	0.136000	7.62e-01	7.34e-02
Downstream signal transduction	29	3.46e-01	5.62e-01	0.13800	-1.01e-01	0.093400	3.47e-01	3.84e-01
Pre-NOTCH Expression and Processing	61	1.24e-01	2.99e-01	0.13700	-5.17e-02	0.127000	4.85e-01	8.66e-02
SLBP independent Processing of Histone Pre-mRNAs	10	7.95e-01	8.80e-01	0.13700	9.95e-02	0.094000	5.86e-01	6.07e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	7.06e-01	8.36e-01	0.13700	-5.98e-02	0.123000	7.43e-01	5.00e-01
Amine ligand-binding receptors	41	2.43e-01	4.55e-01	0.13700	-1.24e-01	0.056800	1.69e-01	5.29e-01
Activation of gene expression by SREBF (SREBP)	42	3.15e-01	5.31e-01	0.13600	1.85e-02	0.135000	8.35e-01	1.30e-01
FOXO-mediated transcription	65	1.57e-01	3.47e-01	0.13600	1.36e-01	0.007350	5.80e-02	9.18e-01
Chondroitin sulfate biosynthesis	18	5.25e-01	7.07e-01	0.13600	-1.02e-01	0.089900	4.53e-01	5.09e-01
Beta-catenin independent WNT signaling	144	3.89e-02	1.34e-01	0.13600	9.39e-02	0.098500	5.16e-02	4.12e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	2.20e-01	4.23e-01	0.13600	1.06e-02	0.135000	8.93e-01	8.55e-02
Transcriptional Regulation by MECP2	60	1.45e-01	3.31e-01	0.13600	-1.31e-01	0.034600	7.90e-02	6.43e-01
Signaling by EGFR in Cancer	25	5.28e-01	7.08e-01	0.13500	3.47e-02	0.131000	7.64e-01	2.59e-01
Glutamate Neurotransmitter Release Cycle	23	5.40e-01	7.21e-01	0.13500	1.33e-01	0.019600	2.68e-01	8.70e-01
Resolution of Sister Chromatid Cohesion	98	7.55e-02	2.13e-01	0.13500	2.35e-02	0.133000	6.88e-01	2.32e-02
Activation of the AP-1 family of transcription factors	10	8.01e-01	8.80e-01	0.13400	1.02e-01	0.087400	5.76e-01	6.32e-01
Sema4D induced cell migration and growth-cone collapse	20	6.10e-01	7.71e-01	0.13400	4.05e-02	0.128000	7.54e-01	3.22e-01
Class I MHC mediated antigen processing & presentation	361	9.62e-05	8.74e-04	0.13400	2.50e-02	0.132000	4.15e-01	1.72e-05
ER to Golgi Anterograde Transport	134	2.46e-02	9.47e-02	0.13400	4.74e-03	0.134000	9.25e-01	7.56e-03
FGFRL1 modulation of FGFR1 signaling	13	7.20e-01	8.44e-01	0.13400	3.13e-02	0.130000	8.45e-01	4.18e-01
Oxidative Stress Induced Senescence	66	1.29e-01	3.08e-01	0.13300	-3.26e-02	0.129000	6.47e-01	6.89e-02
CLEC7A (Dectin-1) induces NFAT activation	11	7.66e-01	8.69e-01	0.13300	-4.30e-02	-0.126000	8.05e-01	4.68e-01
Post-translational protein phosphorylation	100	1.14e-01	2.85e-01	0.13300	-1.02e-01	-0.085200	7.71e-02	1.41e-01
Removal of the Flap Intermediate from the C-strand	17	5.96e-01	7.59e-01	0.13300	-2.67e-02	0.130000	8.49e-01	3.52e-01
Activation of BH3-only proteins	30	3.60e-01	5.74e-01	0.13300	-1.05e-01	0.081500	3.19e-01	4.40e-01
VEGFR2 mediated cell proliferation	19	5.43e-01	7.24e-01	0.13300	-1.23e-01	0.048800	3.51e-01	7.12e-01
PIP3 activates AKT signaling	275	5.54e-04	4.32e-03	0.13300	3.09e-03	0.133000	9.30e-01	1.50e-04
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	4.81e-01	6.78e-01	0.13300	8.68e-02	0.100000	3.81e-01	3.12e-01
FOXO-mediated transcription of cell cycle genes	16	6.94e-01	8.29e-01	0.13200	1.20e-01	0.055700	4.06e-01	7.00e-01
FRS-mediated FGFR2 signaling	24	5.24e-01	7.07e-01	0.13200	6.35e-03	0.132000	9.57e-01	2.63e-01
Arachidonic acid metabolism	56	2.99e-01	5.16e-01	0.13200	1.08e-01	0.076100	1.64e-01	3.25e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	7.46e-01	8.60e-01	0.13100	-3.16e-02	-0.127000	8.50e-01	4.44e-01
Defective EXT2 causes exostoses 2	12	7.46e-01	8.60e-01	0.13100	-3.16e-02	-0.127000	8.50e-01	4.44e-01
RHO GTPases Activate Formins	114	6.70e-02	1.98e-01	0.13100	3.80e-02	0.126000	4.83e-01	2.04e-02
HDMs demethylate histones	18	5.79e-01	7.47e-01	0.13100	-3.49e-02	0.127000	7.98e-01	3.53e-01
HDR through MMEJ (alt-NHEJ)	11	7.62e-01	8.67e-01	0.13100	2.69e-02	0.128000	8.77e-01	4.61e-01
Signal transduction by L1	20	6.07e-01	7.68e-01	0.13000	1.29e-01	0.020700	3.19e-01	8.73e-01
PI3K events in ERBB4 signaling	10	8.11e-01	8.87e-01	0.13000	-1.03e-01	-0.079900	5.74e-01	6.62e-01
Axon guidance	503	2.16e-05	2.18e-04	0.13000	1.15e-01	0.061100	9.73e-06	1.88e-02
Caspase activation via extrinsic apoptotic signalling pathway	25	5.88e-01	7.53e-01	0.13000	6.99e-02	0.110000	5.45e-01	3.42e-01
Integrin cell surface interactions	66	2.27e-01	4.32e-01	0.13000	-1.20e-01	-0.049000	9.04e-02	4.91e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	6.54e-01	8.01e-01	0.13000	-1.83e-02	-0.129000	8.96e-01	3.58e-01
PI-3K cascade:FGFR3	17	7.03e-01	8.35e-01	0.13000	8.24e-02	0.100000	5.57e-01	4.73e-01
Gastrulation	21	5.18e-01	7.04e-01	0.12900	-1.14e-01	0.061400	3.67e-01	6.26e-01
Ca2+ pathway	62	2.83e-01	5.03e-01	0.12900	-8.23e-02	-0.099100	2.62e-01	1.77e-01
RORA activates gene expression	17	5.86e-01	7.52e-01	0.12900	-1.09e-01	0.068300	4.36e-01	6.26e-01
ERBB2 Regulates Cell Motility	15	7.31e-01	8.52e-01	0.12800	-1.11e-01	-0.064800	4.58e-01	6.64e-01
EML4 and NUDC in mitotic spindle formation	93	1.19e-01	2.95e-01	0.12800	3.42e-02	0.124000	5.69e-01	3.95e-02
Death Receptor Signalling	134	6.73e-02	1.98e-01	0.12800	1.01e-01	0.078400	4.29e-02	1.17e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	7.39e-01	8.57e-01	0.12800	-5.23e-02	0.117000	7.75e-01	5.22e-01
Nonhomologous End-Joining (NHEJ)	32	5.27e-01	7.08e-01	0.12800	8.69e-02	0.093900	3.95e-01	3.58e-01
Downstream signaling of activated FGFR2	29	4.93e-01	6.85e-01	0.12800	1.61e-02	0.127000	8.80e-01	2.37e-01
Common Pathway of Fibrin Clot Formation	21	6.45e-01	8.00e-01	0.12800	-6.30e-02	-0.111000	6.17e-01	3.77e-01
Protein-protein interactions at synapses	78	2.00e-01	3.99e-01	0.12800	-6.38e-02	-0.110000	3.30e-01	9.17e-02
G-protein beta:gamma signalling	30	4.13e-01	6.18e-01	0.12700	-1.19e-01	0.045500	2.59e-01	6.66e-01
The role of Nef in HIV-1 replication and disease pathogenesis	27	5.77e-01	7.47e-01	0.12700	1.08e-01	0.067800	3.33e-01	5.42e-01
RND3 GTPase cycle	41	4.13e-01	6.18e-01	0.12700	-1.18e-01	-0.045700	1.89e-01	6.12e-01
SARS-CoV-2 Infection	276	2.82e-03	1.74e-02	0.12700	4.71e-02	0.118000	1.78e-01	7.42e-04
p130Cas linkage to MAPK signaling for integrins	15	6.54e-01	8.01e-01	0.12700	-1.22e-01	0.033700	4.13e-01	8.21e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	5.45e-01	7.24e-01	0.12700	6.60e-02	-0.108000	6.09e-01	4.03e-01
Signaling by Erythropoietin	25	4.70e-01	6.71e-01	0.12600	-6.38e-02	0.109000	5.81e-01	3.44e-01
Depolymerisation of the Nuclear Lamina	14	7.27e-01	8.47e-01	0.12600	2.76e-02	0.123000	8.58e-01	4.24e-01
PLC beta mediated events	47	3.50e-01	5.66e-01	0.12600	-1.22e-01	-0.031900	1.48e-01	7.05e-01
Diseases of signal transduction by growth factor receptors and second messengers	410	8.42e-05	7.70e-04	0.12600	1.87e-02	0.124000	5.16e-01	1.57e-05
Gastrin-CREB signalling pathway via PKC and MAPK	17	6.25e-01	7.85e-01	0.12500	-1.21e-01	0.032700	3.87e-01	8.15e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	7.83e-01	8.74e-01	0.12500	-1.12e-01	-0.056100	5.01e-01	7.36e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	30	5.62e-01	7.39e-01	0.12500	8.86e-02	0.088700	4.01e-01	4.00e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	110	5.52e-02	1.72e-01	0.12500	-1.86e-02	0.124000	7.36e-01	2.47e-02
Interleukin-12 signaling	43	3.69e-01	5.83e-01	0.12500	1.80e-02	0.124000	8.38e-01	1.59e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	7.23e-01	8.45e-01	0.12500	-5.99e-02	0.110000	7.31e-01	5.27e-01
MyD88 cascade initiated on plasma membrane	91	1.45e-01	3.31e-01	0.12500	4.06e-02	0.118000	5.03e-01	5.10e-02
Toll Like Receptor 10 (TLR10) Cascade	91	1.45e-01	3.31e-01	0.12500	4.06e-02	0.118000	5.03e-01	5.10e-02
Toll Like Receptor 5 (TLR5) Cascade	91	1.45e-01	3.31e-01	0.12500	4.06e-02	0.118000	5.03e-01	5.10e-02
Condensation of Prophase Chromosomes	12	7.06e-01	8.36e-01	0.12500	-5.28e-02	0.113000	7.52e-01	4.97e-01
Sensory processing of sound by outer hair cells of the cochlea	49	3.57e-01	5.72e-01	0.12500	-4.30e-02	-0.117000	6.02e-01	1.55e-01
Regulation of actin dynamics for phagocytic cup formation	59	3.17e-01	5.33e-01	0.12500	1.04e-01	0.069400	1.67e-01	3.57e-01
Role of phospholipids in phagocytosis	23	6.13e-01	7.74e-01	0.12500	-3.96e-02	-0.118000	7.42e-01	3.26e-01
Azathioprine ADME	22	5.18e-01	7.04e-01	0.12500	-9.76e-02	0.077500	4.28e-01	5.29e-01
GAB1 signalosome	17	6.13e-01	7.74e-01	0.12500	-1.13e-01	0.053400	4.22e-01	7.03e-01
Sodium/Calcium exchangers	11	7.19e-01	8.44e-01	0.12500	8.14e-02	-0.094200	6.40e-01	5.88e-01
HS-GAG biosynthesis	28	5.86e-01	7.52e-01	0.12400	-7.76e-02	-0.097300	4.77e-01	3.73e-01
Unblocking of NMDA receptors, glutamate binding and activation	19	6.30e-01	7.89e-01	0.12400	-9.28e-04	-0.124000	9.94e-01	3.48e-01
Inositol phosphate metabolism	45	4.13e-01	6.18e-01	0.12400	-1.08e-01	-0.061300	2.10e-01	4.77e-01
N-glycan antennae elongation in the medial/trans-Golgi	26	5.12e-01	7.00e-01	0.12400	-1.23e-01	0.016800	2.78e-01	8.82e-01
Interleukin-12 family signaling	53	3.11e-01	5.28e-01	0.12400	2.50e-02	0.121000	7.53e-01	1.26e-01
Mitotic Prometaphase	174	1.81e-02	7.49e-02	0.12400	1.18e-02	0.123000	7.89e-01	5.00e-03
RND2 GTPase cycle	42	4.16e-01	6.20e-01	0.12400	-1.18e-01	-0.038100	1.87e-01	6.69e-01
Metabolism of proteins	1767	1.32e-14	1.02e-12	0.12300	6.07e-02	0.107000	1.99e-05	4.39e-14
G-protein mediated events	52	3.12e-01	5.28e-01	0.12300	-1.22e-01	-0.017800	1.28e-01	8.24e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	49	3.65e-01	5.79e-01	0.12300	4.00e-02	0.116000	6.28e-01	1.59e-01
COPI-mediated anterograde transport	83	2.09e-01	4.05e-01	0.12300	6.90e-02	0.102000	2.77e-01	1.09e-01
Plasma lipoprotein clearance	37	5.00e-01	6.92e-01	0.12300	1.01e-01	0.070600	2.90e-01	4.58e-01
Resolution of D-Loop Structures	31	5.64e-01	7.40e-01	0.12300	8.01e-02	0.093000	4.40e-01	3.70e-01
RAC2 GTPase cycle	80	1.15e-01	2.87e-01	0.12300	-1.16e-01	0.040100	7.27e-02	5.35e-01
Notch-HLH transcription pathway	24	4.98e-01	6.91e-01	0.12300	-7.96e-02	0.093400	5.00e-01	4.28e-01
Keratan sulfate/keratin metabolism	33	3.91e-01	5.99e-01	0.12200	-6.71e-02	0.102000	5.05e-01	3.09e-01
C-type lectin receptors (CLRs)	137	6.86e-02	2.00e-01	0.12200	4.96e-02	0.112000	3.16e-01	2.39e-02
Nervous system development	527	3.96e-05	3.90e-04	0.12200	1.12e-01	0.049500	1.11e-05	5.15e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	5.89e-01	7.53e-01	0.12200	-1.06e-01	-0.061100	3.33e-01	5.76e-01
RHOC GTPase cycle	69	1.83e-01	3.80e-01	0.12200	-1.21e-01	0.013800	8.20e-02	8.42e-01
Cytokine Signaling in Immune system	670	7.01e-06	8.27e-05	0.12200	7.92e-02	0.092400	4.60e-04	4.34e-05
TRAF6 mediated IRF7 activation	26	4.77e-01	6.76e-01	0.12100	-8.25e-02	0.088900	4.66e-01	4.32e-01
RHOBTB GTPase Cycle	34	5.44e-01	7.24e-01	0.12100	9.18e-02	0.078500	3.54e-01	4.28e-01
FLT3 Signaling	38	4.95e-01	6.88e-01	0.12100	1.05e-01	0.060200	2.64e-01	5.20e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	6.89e-01	8.28e-01	0.12100	1.19e-01	-0.022000	4.27e-01	8.83e-01
Listeria monocytogenes entry into host cells	19	6.58e-01	8.03e-01	0.12000	9.36e-03	0.120000	9.44e-01	3.65e-01
Miscellaneous transport and binding events	21	6.63e-01	8.07e-01	0.12000	-4.07e-02	-0.113000	7.47e-01	3.69e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	29	4.84e-01	6.78e-01	0.12000	-2.64e-02	0.117000	8.05e-01	2.74e-01
Signaling by FGFR1 in disease	37	4.04e-01	6.12e-01	0.12000	-2.02e-02	0.118000	8.32e-01	2.12e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27	5.80e-01	7.47e-01	0.12000	-3.12e-02	-0.116000	7.79e-01	2.97e-01
Disease	1567	6.99e-13	3.00e-11	0.11900	4.19e-02	0.111000	5.41e-03	1.43e-13
Phase I - Functionalization of compounds	100	6.70e-02	1.98e-01	0.11900	7.07e-02	-0.095500	2.22e-01	9.88e-02
FGFR4 ligand binding and activation	13	7.99e-01	8.80e-01	0.11900	8.13e-02	0.086600	6.12e-01	5.89e-01
Synthesis of very long-chain fatty acyl-CoAs	23	6.39e-01	7.94e-01	0.11900	-3.41e-02	-0.114000	7.77e-01	3.45e-01
Glucagon signaling in metabolic regulation	33	4.07e-01	6.15e-01	0.11900	-8.42e-02	0.083600	4.02e-01	4.06e-01
Iron uptake and transport	57	3.53e-01	5.69e-01	0.11800	4.85e-02	0.108000	5.27e-01	1.59e-01
Elastic fibre formation	40	3.83e-01	5.94e-01	0.11800	-1.16e-01	0.024100	2.06e-01	7.92e-01
IL-6-type cytokine receptor ligand interactions	17	7.49e-01	8.60e-01	0.11800	-8.58e-02	-0.081000	5.40e-01	5.63e-01
LDL clearance	19	6.65e-01	8.07e-01	0.11800	1.18e-01	0.005110	3.75e-01	9.69e-01
Metal ion SLC transporters	25	6.04e-01	7.66e-01	0.11800	2.02e-02	0.116000	8.61e-01	3.16e-01
Signaling by cytosolic FGFR1 fusion mutants	17	6.38e-01	7.94e-01	0.11700	-9.62e-02	0.067400	4.92e-01	6.30e-01
Organic cation/anion/zwitterion transport	15	6.94e-01	8.29e-01	0.11700	3.21e-02	-0.113000	8.30e-01	4.49e-01
Heme biosynthesis	13	7.87e-01	8.77e-01	0.11700	-4.28e-02	-0.109000	7.89e-01	4.95e-01
FRS-mediated FGFR4 signaling	21	6.00e-01	7.62e-01	0.11700	-3.26e-02	0.113000	7.96e-01	3.71e-01
Interferon alpha/beta signaling	69	2.94e-01	5.13e-01	0.11700	1.06e-01	0.050400	1.30e-01	4.69e-01
ADP signalling through P2Y purinoceptor 12	22	5.81e-01	7.47e-01	0.11700	-1.10e-01	0.040200	3.73e-01	7.44e-01
Transport to the Golgi and subsequent modification	165	2.37e-02	9.29e-02	0.11700	-1.54e-02	0.116000	7.33e-01	1.03e-02
Formation of tubulin folding intermediates by CCT/TriC	26	6.36e-01	7.92e-01	0.11600	1.03e-01	0.054200	3.63e-01	6.33e-01
Gene Silencing by RNA	80	1.46e-01	3.32e-01	0.11600	-3.43e-02	0.111000	5.96e-01	8.56e-02
RND1 GTPase cycle	41	4.03e-01	6.11e-01	0.11600	-1.16e-01	0.010400	2.00e-01	9.09e-01
Sema4D in semaphorin signaling	24	6.35e-01	7.92e-01	0.11600	2.97e-02	0.112000	8.01e-01	3.41e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	7.78e-01	8.74e-01	0.11600	-1.16e-01	-0.004720	4.87e-01	9.77e-01
Estrogen-dependent gene expression	91	2.06e-01	4.02e-01	0.11600	5.23e-02	0.104000	3.88e-01	8.75e-02
Netrin-1 signaling	49	4.23e-01	6.29e-01	0.11600	-4.95e-02	-0.105000	5.49e-01	2.04e-01
Regulation of KIT signaling	16	7.66e-01	8.69e-01	0.11600	-6.63e-02	-0.094600	6.46e-01	5.12e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37	3.89e-01	5.98e-01	0.11500	-9.28e-02	0.068500	3.29e-01	4.71e-01
CRMPs in Sema3A signaling	15	6.80e-01	8.20e-01	0.11500	8.09e-02	-0.082000	5.87e-01	5.82e-01
Endogenous sterols	26	6.53e-01	8.01e-01	0.11500	-6.99e-02	-0.091600	5.37e-01	4.19e-01
N-Glycan antennae elongation	15	7.09e-01	8.38e-01	0.11500	-2.54e-02	0.112000	8.65e-01	4.52e-01
EGFR downregulation	30	5.94e-01	7.58e-01	0.11500	1.05e-01	0.046600	3.19e-01	6.59e-01
Association of TriC/CCT with target proteins during biosynthesis	38	5.45e-01	7.24e-01	0.11400	8.03e-02	0.081400	3.91e-01	3.85e-01
Other interleukin signaling	24	6.69e-01	8.10e-01	0.11400	4.91e-02	0.102000	6.77e-01	3.85e-01
Sensory processing of sound	69	2.85e-01	5.05e-01	0.11300	-2.60e-02	-0.110000	7.08e-01	1.13e-01
Signaling by Interleukins	434	1.16e-03	8.27e-03	0.11300	7.00e-02	0.089100	1.23e-02	1.44e-03
Regulation of PLK1 Activity at G2/M Transition	83	2.26e-01	4.31e-01	0.11300	2.79e-02	0.109000	6.60e-01	8.48e-02
Intrinsic Pathway for Apoptosis	52	4.45e-01	6.53e-01	0.11200	8.96e-02	0.067700	2.63e-01	3.99e-01
Signaling by Leptin	11	8.35e-01	9.01e-01	0.11200	4.89e-02	0.101000	7.79e-01	5.62e-01
Synthesis of PC	27	5.63e-01	7.39e-01	0.11200	-1.88e-02	0.111000	8.66e-01	3.20e-01
Factors involved in megakaryocyte development and platelet production	128	5.16e-02	1.66e-01	0.11200	-1.01e-01	0.048000	4.81e-02	3.48e-01
RAB GEFs exchange GTP for GDP on RABs	82	1.38e-01	3.22e-01	0.11200	-7.86e-02	0.079700	2.18e-01	2.12e-01
Downstream signaling of activated FGFR4	26	5.82e-01	7.49e-01	0.11200	-1.42e-02	0.111000	9.00e-01	3.28e-01
Metabolism of fat-soluble vitamins	46	3.63e-01	5.77e-01	0.11200	3.14e-02	-0.107000	7.13e-01	2.09e-01
Intracellular signaling by second messengers	313	2.11e-03	1.36e-02	0.11100	-3.70e-03	0.111000	9.10e-01	6.91e-04
Signaling by NTRK2 (TRKB)	25	5.78e-01	7.47e-01	0.11100	-3.11e-02	0.107000	7.88e-01	3.55e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	29	5.06e-01	6.97e-01	0.11100	9.32e-02	-0.060300	3.85e-01	5.74e-01
Sensory processing of sound by inner hair cells of the cochlea	62	2.99e-01	5.16e-01	0.11100	1.33e-03	-0.111000	9.86e-01	1.31e-01
Synthesis of IP3 and IP4 in the cytosol	25	6.50e-01	8.01e-01	0.11100	-2.82e-02	-0.107000	8.07e-01	3.54e-01
DSCAM interactions	11	8.25e-01	8.99e-01	0.11100	-1.08e-01	-0.024300	5.36e-01	8.89e-01
RHOF GTPase cycle	40	5.50e-01	7.29e-01	0.11000	-8.35e-02	-0.072300	3.61e-01	4.29e-01
Apoptotic execution phase	43	3.75e-01	5.85e-01	0.11000	-9.76e-02	0.051700	2.68e-01	5.58e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	7.70e-01	8.70e-01	0.11000	1.08e-01	0.023100	4.69e-01	8.77e-01
Signaling by WNT	263	1.52e-02	6.55e-02	0.11000	4.30e-02	0.102000	2.30e-01	4.56e-03
PI3K events in ERBB2 signaling	16	7.68e-01	8.70e-01	0.11000	-3.40e-02	-0.104000	8.14e-01	4.70e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	117	1.40e-01	3.26e-01	0.10900	-2.73e-02	-0.106000	6.10e-01	4.75e-02
Growth hormone receptor signaling	24	6.00e-01	7.62e-01	0.10900	3.20e-02	-0.105000	7.86e-01	3.75e-01
Chromatin modifying enzymes	186	2.64e-02	1.00e-01	0.10900	-1.07e-02	0.109000	8.01e-01	1.05e-02
Chromatin organization	186	2.64e-02	1.00e-01	0.10900	-1.07e-02	0.109000	8.01e-01	1.05e-02
Blood group systems biosynthesis	22	7.04e-01	8.35e-01	0.10900	-1.02e-01	-0.039500	4.09e-01	7.49e-01
Signaling by FGFR in disease	61	3.98e-01	6.08e-01	0.10900	5.17e-02	0.095500	4.85e-01	1.97e-01
Post-chaperonin tubulin folding pathway	23	6.56e-01	8.02e-01	0.10900	3.49e-03	0.108000	9.77e-01	3.68e-01
Signaling by ERBB2 ECD mutants	15	7.77e-01	8.74e-01	0.10800	2.27e-02	0.106000	8.79e-01	4.77e-01
Ion channel transport	168	9.01e-02	2.40e-01	0.10800	-6.50e-02	-0.086200	1.46e-01	5.39e-02
Defective B3GAT3 causes JDSSDHD	17	7.68e-01	8.70e-01	0.10700	-3.76e-02	-0.101000	7.88e-01	4.72e-01
Interleukin-17 signaling	66	2.71e-01	4.87e-01	0.10700	-2.21e-02	0.105000	7.56e-01	1.40e-01
Ion transport by P-type ATPases	51	3.99e-01	6.08e-01	0.10700	-1.32e-03	-0.107000	9.87e-01	1.85e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	8.09e-01	8.85e-01	0.10700	-8.28e-02	-0.068000	5.79e-01	6.49e-01
Lewis blood group biosynthesis	18	7.32e-01	8.53e-01	0.10700	-1.06e-01	-0.010000	4.34e-01	9.41e-01
Serotonin receptors	11	8.52e-01	9.08e-01	0.10700	-5.15e-02	-0.093600	7.67e-01	5.91e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	101	1.61e-01	3.54e-01	0.10700	2.05e-03	-0.107000	9.72e-01	6.40e-02
Innate Immune System	999	5.84e-08	1.28e-06	0.10600	6.89e-03	0.106000	7.12e-01	1.24e-08
FCGR3A-mediated phagocytosis	57	4.55e-01	6.63e-01	0.10600	8.10e-02	0.068600	2.90e-01	3.71e-01
Leishmania phagocytosis	57	4.55e-01	6.63e-01	0.10600	8.10e-02	0.068600	2.90e-01	3.71e-01
Parasite infection	57	4.55e-01	6.63e-01	0.10600	8.10e-02	0.068600	2.90e-01	3.71e-01
Prostacyclin signalling through prostacyclin receptor	19	6.65e-01	8.07e-01	0.10600	-5.85e-02	0.088400	6.59e-01	5.05e-01
Signaling by KIT in disease	20	6.51e-01	8.01e-01	0.10600	-6.07e-02	0.086800	6.38e-01	5.02e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	6.51e-01	8.01e-01	0.10600	-6.07e-02	0.086800	6.38e-01	5.02e-01
Regulation of signaling by CBL	18	7.57e-01	8.65e-01	0.10600	-3.08e-02	-0.101000	8.21e-01	4.57e-01
Ras activation upon Ca2+ influx through NMDA receptor	19	7.72e-01	8.71e-01	0.10600	-7.12e-02	-0.078000	5.91e-01	5.56e-01
Cytochrome P450 - arranged by substrate type	64	3.01e-01	5.17e-01	0.10500	1.73e-02	-0.104000	8.11e-01	1.50e-01
Recycling pathway of L1	23	6.45e-01	8.00e-01	0.10500	-1.03e-01	0.020700	3.91e-01	8.64e-01
Incretin synthesis, secretion, and inactivation	23	6.13e-01	7.74e-01	0.10500	-6.13e-02	0.085700	6.11e-01	4.77e-01
Glycogen breakdown (glycogenolysis)	11	7.96e-01	8.80e-01	0.10500	-8.98e-02	0.053500	6.06e-01	7.59e-01
NOD1/2 Signaling Pathway	29	5.72e-01	7.43e-01	0.10400	-3.14e-02	0.099100	7.69e-01	3.56e-01
Reproduction	82	3.30e-01	5.45e-01	0.10400	-8.78e-02	-0.055500	1.69e-01	3.85e-01
RHO GTPases activate PAKs	19	7.13e-01	8.40e-01	0.10400	1.09e-02	-0.103000	9.35e-01	4.36e-01
Molecules associated with elastic fibres	29	6.31e-01	7.90e-01	0.10400	-1.03e-01	-0.014600	3.39e-01	8.92e-01
RHOBTB1 GTPase cycle	22	7.49e-01	8.60e-01	0.10400	7.14e-02	0.075100	5.62e-01	5.42e-01
Interleukin-37 signaling	20	6.97e-01	8.31e-01	0.10400	-1.02e-01	0.015000	4.27e-01	9.07e-01
Scavenging by Class A Receptors	19	7.80e-01	8.74e-01	0.10300	-7.24e-02	-0.073900	5.85e-01	5.77e-01
Diseases associated with glycosaminoglycan metabolism	38	5.98e-01	7.60e-01	0.10300	-8.96e-02	-0.051300	3.39e-01	5.84e-01
Signaling by Hippo	19	7.80e-01	8.74e-01	0.10300	-7.59e-02	-0.070000	5.67e-01	5.97e-01
Mitochondrial Fatty Acid Beta-Oxidation	35	5.24e-01	7.07e-01	0.10300	-2.42e-02	0.100000	8.04e-01	3.05e-01
activated TAK1 mediates p38 MAPK activation	16	7.23e-01	8.45e-01	0.10300	-6.54e-02	0.079000	6.51e-01	5.84e-01
Centrosome maturation	76	2.93e-01	5.12e-01	0.10200	4.75e-03	0.102000	9.43e-01	1.23e-01
Recruitment of mitotic centrosome proteins and complexes	76	2.93e-01	5.12e-01	0.10200	4.75e-03	0.102000	9.43e-01	1.23e-01
AURKA Activation by TPX2	68	3.77e-01	5.88e-01	0.10200	3.04e-02	0.097500	6.65e-01	1.64e-01
mRNA Editing	10	8.78e-01	9.26e-01	0.10200	8.56e-02	0.055600	6.39e-01	7.61e-01
EPH-ephrin mediated repulsion of cells	48	4.49e-01	6.57e-01	0.10200	-3.55e-03	0.102000	9.66e-01	2.21e-01
RAF/MAP kinase cascade	264	3.40e-02	1.22e-01	0.10200	5.89e-02	0.083300	9.94e-02	1.97e-02
Recruitment of NuMA to mitotic centrosomes	75	2.91e-01	5.10e-01	0.10200	-1.47e-03	0.102000	9.82e-01	1.27e-01
Transcriptional regulation by RUNX1	183	5.79e-02	1.79e-01	0.10200	1.01e-02	0.101000	8.13e-01	1.79e-02
SHC1 events in ERBB2 signaling	22	6.50e-01	8.01e-01	0.10200	-8.71e-02	0.052500	4.79e-01	6.70e-01
Post-translational protein modification	1289	1.33e-08	3.45e-07	0.10200	2.17e-02	0.099300	1.88e-01	1.72e-09
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	42	4.33e-01	6.39e-01	0.10100	-7.27e-02	0.070800	4.15e-01	4.27e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	52	5.11e-01	7.00e-01	0.10100	5.42e-02	0.085700	4.99e-01	2.85e-01
Tight junction interactions	28	6.95e-01	8.29e-01	0.10100	-8.79e-02	-0.049900	4.21e-01	6.48e-01
RHO GTPase Effectors	232	3.02e-02	1.12e-01	0.10100	1.26e-02	0.100000	7.42e-01	8.50e-03
Signaling by EGFR	49	4.78e-01	6.77e-01	0.10100	1.43e-02	0.099900	8.63e-01	2.26e-01
CaMK IV-mediated phosphorylation of CREB	10	8.41e-01	9.03e-01	0.10100	1.96e-02	-0.098600	9.14e-01	5.89e-01
Signaling by FGFR3 in disease	21	7.15e-01	8.41e-01	0.10000	-1.01e-03	0.100000	9.94e-01	4.26e-01
Translation of Structural Proteins 9683701	29	6.93e-01	8.29e-01	0.10000	5.37e-02	0.084600	6.17e-01	4.30e-01
Interleukin-7 signaling	21	6.93e-01	8.29e-01	0.10000	9.73e-02	-0.023400	4.40e-01	8.53e-01
Signaling by BRAF and RAF1 fusions	60	3.27e-01	5.45e-01	0.09970	-8.77e-02	0.047400	2.40e-01	5.26e-01
Protein folding	96	2.52e-01	4.66e-01	0.09960	1.82e-02	0.097900	7.57e-01	9.71e-02
MAPK1/MAPK3 signaling	270	3.75e-02	1.31e-01	0.09960	5.92e-02	0.080100	9.38e-02	2.34e-02
TP53 Regulates Transcription of Caspase Activators and Caspases	12	8.38e-01	9.02e-01	0.09950	-9.86e-02	-0.013400	5.54e-01	9.36e-01
Pre-NOTCH Transcription and Translation	45	4.77e-01	6.76e-01	0.09940	-1.20e-02	0.098700	8.90e-01	2.52e-01
RHO GTPases activate CIT	19	7.42e-01	8.59e-01	0.09920	9.92e-02	-0.002010	4.54e-01	9.88e-01
Processing of SMDT1	15	7.63e-01	8.68e-01	0.09920	3.79e-02	-0.091700	7.99e-01	5.39e-01
Regulation of MECP2 expression and activity	30	6.05e-01	7.66e-01	0.09860	-9.66e-02	0.020100	3.60e-01	8.49e-01
Cell surface interactions at the vascular wall	127	9.32e-02	2.46e-01	0.09850	-7.09e-02	0.068300	1.67e-01	1.84e-01
Activation of BAD and translocation to mitochondria	15	7.78e-01	8.74e-01	0.09840	-9.61e-02	0.021000	5.19e-01	8.88e-01
Regulation of IFNG signaling	14	7.73e-01	8.72e-01	0.09840	-5.36e-02	0.082400	7.28e-01	5.93e-01
Neurotransmitter release cycle	47	4.65e-01	6.70e-01	0.09830	9.72e-02	-0.015000	2.49e-01	8.59e-01
PECAM1 interactions	12	8.65e-01	9.16e-01	0.09810	5.20e-02	0.083100	7.55e-01	6.18e-01
Extra-nuclear estrogen signaling	73	2.65e-01	4.79e-01	0.09800	-8.33e-02	0.051700	2.19e-01	4.45e-01
Basigin interactions	24	7.49e-01	8.60e-01	0.09790	5.32e-02	0.082200	6.52e-01	4.86e-01
ADORA2B mediated anti-inflammatory cytokines production	42	5.12e-01	7.00e-01	0.09790	-9.72e-02	0.011900	2.76e-01	8.94e-01
Signaling by SCF-KIT	43	4.96e-01	6.88e-01	0.09780	-9.62e-02	0.017700	2.75e-01	8.41e-01
Defects in vitamin and cofactor metabolism	20	7.83e-01	8.74e-01	0.09770	4.59e-02	0.086200	7.22e-01	5.04e-01
GPER1 signaling	44	4.49e-01	6.57e-01	0.09750	-7.94e-02	0.056500	3.62e-01	5.17e-01
Regulation of gene expression in beta cells	21	7.83e-01	8.74e-01	0.09730	6.22e-02	0.074800	6.22e-01	5.53e-01
Nuclear Receptor transcription pathway	51	4.27e-01	6.33e-01	0.09710	-9.32e-02	0.027300	2.50e-01	7.36e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	6.47e-01	8.01e-01	0.09670	-4.34e-02	0.086400	7.07e-01	4.55e-01
Class B/2 (Secretin family receptors)	94	2.08e-01	4.04e-01	0.09660	-3.13e-02	0.091400	5.99e-01	1.26e-01
Synaptic adhesion-like molecules	19	7.12e-01	8.39e-01	0.09650	7.79e-02	-0.057000	5.56e-01	6.67e-01
RMTs methylate histone arginines	30	6.71e-01	8.11e-01	0.09640	2.03e-02	0.094200	8.48e-01	3.72e-01
HATs acetylate histones	71	3.70e-01	5.84e-01	0.09620	8.80e-03	0.095800	8.98e-01	1.62e-01
Opioid Signalling	88	2.76e-01	4.93e-01	0.09620	-9.62e-02	0.000823	1.19e-01	9.89e-01
RUNX2 regulates osteoblast differentiation	22	7.37e-01	8.55e-01	0.09620	1.04e-02	0.095600	9.33e-01	4.37e-01
Signaling by PDGF	52	5.16e-01	7.04e-01	0.09600	-9.19e-02	-0.027700	2.52e-01	7.29e-01
Deadenylation of mRNA	25	7.03e-01	8.35e-01	0.09580	-9.56e-02	-0.006240	4.08e-01	9.57e-01
Ca-dependent events	35	6.76e-01	8.15e-01	0.09560	-6.49e-02	-0.070200	5.06e-01	4.72e-01
Hyaluronan metabolism	17	7.66e-01	8.69e-01	0.09560	-1.92e-02	0.093700	8.91e-01	5.04e-01
RAS processing	19	7.91e-01	8.79e-01	0.09470	-9.03e-02	-0.028600	4.96e-01	8.29e-01
Aquaporin-mediated transport	51	5.72e-01	7.43e-01	0.09430	-7.47e-02	-0.057500	3.56e-01	4.78e-01
Translation of Structural Proteins 9694635	55	4.68e-01	6.71e-01	0.09430	2.91e-03	0.094200	9.70e-01	2.27e-01
G beta:gamma signalling through PLC beta	20	7.34e-01	8.54e-01	0.09420	-9.17e-02	0.021700	4.78e-01	8.66e-01
Signaling by NOTCH1	69	4.68e-01	6.71e-01	0.09420	5.43e-02	0.077000	4.35e-01	2.69e-01
RHOG GTPase cycle	69	4.29e-01	6.34e-01	0.09410	-9.04e-02	-0.026000	1.94e-01	7.09e-01
PI-3K cascade:FGFR2	22	7.90e-01	8.78e-01	0.09370	6.69e-02	0.065600	5.87e-01	5.94e-01
Long-term potentiation	22	7.58e-01	8.66e-01	0.09360	-1.89e-02	-0.091600	8.78e-01	4.57e-01
PKMTs methylate histone lysines	37	5.60e-01	7.37e-01	0.09320	-8.75e-02	0.031900	3.57e-01	7.37e-01
Fatty acid metabolism	167	1.54e-01	3.43e-01	0.09300	3.99e-02	0.084000	3.73e-01	6.08e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	20	7.41e-01	8.58e-01	0.09300	-2.08e-02	0.090700	8.72e-01	4.83e-01
Attachment and Entry 9694614	16	8.34e-01	9.01e-01	0.09250	-8.56e-02	-0.034900	5.53e-01	8.09e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	8.38e-01	9.02e-01	0.09230	-1.71e-03	0.092300	9.91e-01	5.65e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	6.90e-01	8.28e-01	0.09220	9.17e-02	0.009200	3.93e-01	9.32e-01
Trafficking of AMPA receptors	29	6.90e-01	8.28e-01	0.09220	9.17e-02	0.009200	3.93e-01	9.32e-01
MAPK3 (ERK1) activation	10	8.49e-01	9.07e-01	0.09210	6.41e-02	-0.066100	7.25e-01	7.17e-01
Chaperonin-mediated protein folding	90	3.36e-01	5.52e-01	0.09210	1.93e-02	0.090000	7.51e-01	1.40e-01
Dermatan sulfate biosynthesis	10	8.85e-01	9.31e-01	0.09200	-1.80e-02	-0.090200	9.22e-01	6.21e-01
CD28 co-stimulation	32	6.32e-01	7.90e-01	0.09180	-9.04e-02	0.016300	3.76e-01	8.73e-01
Signaling by ERBB2 TMD/JMD mutants	21	7.17e-01	8.43e-01	0.09180	-4.39e-02	0.080600	7.28e-01	5.22e-01
Pregnenolone biosynthesis	10	8.96e-01	9.36e-01	0.09140	8.30e-02	0.038300	6.49e-01	8.34e-01
Integration of energy metabolism	106	1.83e-01	3.80e-01	0.09130	-5.69e-02	0.071400	3.11e-01	2.04e-01
RA biosynthesis pathway	22	7.10e-01	8.39e-01	0.09120	-4.21e-02	0.080800	7.32e-01	5.12e-01
Carboxyterminal post-translational modifications of tubulin	40	5.56e-01	7.35e-01	0.09110	8.76e-02	-0.025100	3.38e-01	7.84e-01
Regulation of insulin secretion	77	2.97e-01	5.16e-01	0.09110	-4.89e-02	0.076900	4.58e-01	2.43e-01
MHC class II antigen presentation	104	3.45e-01	5.61e-01	0.09050	4.95e-02	0.075800	3.83e-01	1.82e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	7.73e-01	8.72e-01	0.09030	-7.69e-02	-0.047300	5.05e-01	6.82e-01
Signaling by MET	66	3.68e-01	5.81e-01	0.09010	-8.02e-02	0.041100	2.59e-01	5.64e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	23	7.03e-01	8.35e-01	0.09010	-7.80e-02	0.045200	5.17e-01	7.07e-01
GABA synthesis, release, reuptake and degradation	19	7.52e-01	8.62e-01	0.08950	7.91e-02	-0.042000	5.51e-01	7.51e-01
G alpha (i) signalling events	305	5.19e-02	1.66e-01	0.08940	-6.74e-02	-0.058700	4.26e-02	7.74e-02
GABA receptor activation	57	5.19e-01	7.04e-01	0.08940	-8.77e-02	-0.017200	2.52e-01	8.22e-01
Interleukin receptor SHC signaling	24	7.70e-01	8.70e-01	0.08910	-8.50e-02	-0.026800	4.71e-01	8.20e-01
Immune System	1870	4.57e-09	1.36e-07	0.08900	2.39e-02	0.085800	8.51e-02	6.08e-10
GPCR downstream signalling	603	2.91e-03	1.78e-02	0.08890	-7.46e-02	-0.048400	1.72e-03	4.21e-02
Signaling by ERBB2	49	5.32e-01	7.13e-01	0.08890	-6.89e-03	0.088600	9.34e-01	2.83e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	8.53e-01	9.09e-01	0.08860	-3.45e-02	0.081600	8.43e-01	6.39e-01
Defects in cobalamin (B12) metabolism	12	8.89e-01	9.31e-01	0.08850	4.80e-02	0.074400	7.73e-01	6.56e-01
EPHA-mediated growth cone collapse	15	7.99e-01	8.80e-01	0.08830	5.03e-02	-0.072600	7.36e-01	6.26e-01
Meiosis	56	4.62e-01	6.68e-01	0.08830	-8.47e-02	0.025000	2.73e-01	7.47e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	21	8.09e-01	8.85e-01	0.08800	7.98e-02	0.037200	5.27e-01	7.68e-01
A tetrasaccharide linker sequence is required for GAG synthesis	23	8.00e-01	8.80e-01	0.08770	-4.53e-02	-0.075100	7.07e-01	5.33e-01
Inwardly rectifying K+ channels	35	7.11e-01	8.39e-01	0.08760	-4.34e-02	-0.076100	6.57e-01	4.36e-01
CD209 (DC-SIGN) signaling	20	8.33e-01	9.01e-01	0.08640	-6.37e-02	-0.058400	6.22e-01	6.51e-01
Loss of Nlp from mitotic centrosomes	65	4.73e-01	6.73e-01	0.08610	2.86e-03	0.086000	9.68e-01	2.30e-01
Loss of proteins required for interphase microtubule organization from the centrosome	65	4.73e-01	6.73e-01	0.08610	2.86e-03	0.086000	9.68e-01	2.30e-01
ROS and RNS production in phagocytes	35	6.25e-01	7.85e-01	0.08590	-3.17e-02	0.079800	7.46e-01	4.14e-01
RHO GTPase cycle	420	4.74e-03	2.67e-02	0.08520	-8.12e-02	0.025800	4.27e-03	3.64e-01
Pyroptosis	26	7.60e-01	8.67e-01	0.08490	1.35e-02	0.083800	9.05e-01	4.59e-01
RAC1 GTPase cycle	170	1.41e-01	3.27e-01	0.08480	-8.47e-02	0.004130	5.67e-02	9.26e-01
Sphingolipid metabolism	81	3.28e-01	5.45e-01	0.08460	-5.37e-02	0.065400	4.03e-01	3.09e-01
MAPK family signaling cascades	311	6.32e-02	1.91e-01	0.08460	4.58e-02	0.071200	1.65e-01	3.08e-02
Organelle biogenesis and maintenance	243	8.66e-02	2.36e-01	0.08440	1.87e-02	0.082300	6.15e-01	2.70e-02
G beta:gamma signalling through BTK	17	7.92e-01	8.80e-01	0.08440	-6.63e-02	0.052300	6.36e-01	7.09e-01
Adaptive Immune System	709	1.69e-03	1.12e-02	0.08430	3.63e-02	0.076100	9.92e-02	5.42e-04
Metabolic disorders of biological oxidation enzymes	32	7.56e-01	8.65e-01	0.08420	-5.32e-02	-0.065300	6.03e-01	5.22e-01
L1CAM interactions	92	3.95e-01	6.04e-01	0.08410	-1.75e-02	-0.082200	7.71e-01	1.73e-01
NRAGE signals death through JNK	53	6.34e-01	7.92e-01	0.08390	-6.14e-02	-0.057200	4.39e-01	4.71e-01
Effects of PIP2 hydrolysis	26	7.99e-01	8.80e-01	0.08390	-6.32e-02	-0.055100	5.77e-01	6.27e-01
Regulation of lipid metabolism by PPARalpha	116	2.62e-01	4.76e-01	0.08360	-9.50e-03	0.083100	8.60e-01	1.22e-01
Glucagon-type ligand receptors	33	6.57e-01	8.03e-01	0.08360	-7.78e-02	0.030500	4.39e-01	7.62e-01
Metabolism of carbohydrates	275	4.12e-02	1.41e-01	0.08330	-1.31e-02	0.082200	7.09e-01	1.88e-02
Diseases of glycosylation	137	2.98e-01	5.16e-01	0.08320	-7.33e-02	-0.039400	1.38e-01	4.26e-01
Insulin receptor recycling	26	7.46e-01	8.60e-01	0.08320	-5.69e-03	0.083000	9.60e-01	4.64e-01
Defective B4GALT7 causes EDS, progeroid type	17	8.66e-01	9.17e-01	0.08310	-5.43e-02	-0.063000	6.99e-01	6.53e-01
Membrane Trafficking	585	1.20e-03	8.50e-03	0.08310	-1.45e-02	0.081800	5.49e-01	6.99e-04
Biotin transport and metabolism	10	9.01e-01	9.38e-01	0.08300	7.47e-03	0.082700	9.67e-01	6.51e-01
G alpha (q) signalling events	206	1.21e-01	2.97e-01	0.08300	-8.25e-02	-0.009350	4.12e-02	8.17e-01
Muscle contraction	193	1.03e-01	2.65e-01	0.08300	1.68e-02	-0.081200	6.87e-01	5.15e-02
Keratan sulfate biosynthesis	28	6.94e-01	8.29e-01	0.08280	-7.00e-02	0.044200	5.21e-01	6.85e-01
Synthesis, secretion, and deacylation of Ghrelin	19	8.38e-01	9.02e-01	0.08270	7.80e-02	0.027400	5.56e-01	8.36e-01
NCAM signaling for neurite out-growth	57	4.77e-01	6.76e-01	0.08240	6.73e-02	-0.047600	3.79e-01	5.35e-01
Adenylate cyclase activating pathway	10	8.88e-01	9.31e-01	0.08220	2.05e-02	-0.079600	9.11e-01	6.63e-01
Smooth Muscle Contraction	43	5.71e-01	7.43e-01	0.08220	6.28e-02	-0.053000	4.76e-01	5.48e-01
Prolonged ERK activation events	14	8.91e-01	9.32e-01	0.08170	-6.57e-02	-0.048500	6.70e-01	7.53e-01
Syndecan interactions	19	7.89e-01	8.78e-01	0.08160	-7.25e-02	0.037500	5.84e-01	7.77e-01
ESR-mediated signaling	160	1.73e-01	3.70e-01	0.08100	-1.16e-02	0.080200	8.01e-01	7.99e-02
Plasma lipoprotein assembly, remodeling, and clearance	73	4.02e-01	6.11e-01	0.08100	4.52e-02	-0.067200	5.04e-01	3.21e-01
Heparan sulfate/heparin (HS-GAG) metabolism	49	6.69e-01	8.10e-01	0.08090	-6.85e-02	-0.042900	4.07e-01	6.03e-01
PPARA activates gene expression	114	2.85e-01	5.05e-01	0.08030	-1.53e-02	0.078800	7.77e-01	1.46e-01
Germ layer formation at gastrulation	16	8.33e-01	9.01e-01	0.08030	-7.68e-02	0.023300	5.95e-01	8.72e-01
Cardiac conduction	123	2.68e-01	4.84e-01	0.07990	1.14e-02	-0.079100	8.27e-01	1.29e-01
Interleukin-6 family signaling	24	8.24e-01	8.98e-01	0.07990	-4.07e-02	-0.068700	7.30e-01	5.60e-01
Metabolism of steroids	148	2.38e-01	4.47e-01	0.07980	-5.63e-03	-0.079600	9.06e-01	9.43e-02
Phospholipid metabolism	192	1.14e-01	2.84e-01	0.07940	-7.45e-02	0.027500	7.50e-02	5.11e-01
Hemostasis	555	1.73e-03	1.14e-02	0.07920	-7.07e-02	0.035700	4.32e-03	1.50e-01
Intraflagellar transport	36	6.94e-01	8.29e-01	0.07900	-5.23e-03	0.078800	9.57e-01	4.13e-01
Sema3A PAK dependent Axon repulsion	14	8.98e-01	9.37e-01	0.07860	-6.33e-02	-0.046500	6.82e-01	7.63e-01
Anti-inflammatory response favouring Leishmania parasite infection	75	5.70e-01	7.43e-01	0.07840	-5.67e-02	-0.054100	3.96e-01	4.17e-01
Leishmania parasite growth and survival	75	5.70e-01	7.43e-01	0.07840	-5.67e-02	-0.054100	3.96e-01	4.17e-01
EPH-Ephrin signaling	90	5.11e-01	7.00e-01	0.07810	5.16e-02	0.058700	3.98e-01	3.36e-01
FCERI mediated Ca+2 mobilization	27	8.19e-01	8.94e-01	0.07770	-5.44e-02	-0.055500	6.25e-01	6.17e-01
DAG and IP3 signaling	39	7.42e-01	8.59e-01	0.07740	-6.75e-02	-0.038000	4.66e-01	6.82e-01
Pyruvate metabolism	29	7.75e-01	8.73e-01	0.07740	1.20e-02	0.076400	9.11e-01	4.76e-01
Metabolism of folate and pterines	16	8.47e-01	9.07e-01	0.07670	-2.00e-02	0.074000	8.90e-01	6.08e-01
Signaling by ALK	26	7.82e-01	8.74e-01	0.07660	7.65e-02	-0.003530	4.99e-01	9.75e-01
Prolactin receptor signaling	15	8.57e-01	9.12e-01	0.07630	-2.07e-02	0.073400	8.90e-01	6.23e-01
Oncogenic MAPK signaling	76	4.31e-01	6.36e-01	0.07590	-5.90e-02	0.047800	3.74e-01	4.71e-01
Glyoxylate metabolism and glycine degradation	30	7.98e-01	8.80e-01	0.07570	3.06e-02	0.069200	7.72e-01	5.12e-01
Crosslinking of collagen fibrils	10	9.21e-01	9.53e-01	0.07530	7.42e-02	0.013000	6.85e-01	9.43e-01
Constitutive Signaling by EGFRvIII	15	9.01e-01	9.38e-01	0.07530	5.48e-02	0.051600	7.13e-01	7.29e-01
Signaling by EGFRvIII in Cancer	15	9.01e-01	9.38e-01	0.07530	5.48e-02	0.051600	7.13e-01	7.29e-01
Signaling by TGF-beta Receptor Complex	90	4.56e-01	6.64e-01	0.07520	3.39e-03	0.075100	9.56e-01	2.18e-01
Clathrin-mediated endocytosis	135	3.73e-01	5.85e-01	0.07520	3.29e-02	0.067600	5.09e-01	1.75e-01
Platelet activation, signaling and aggregation	245	7.32e-02	2.10e-01	0.07470	-5.77e-02	0.047500	1.20e-01	2.00e-01
Metabolism	1963	1.13e-06	1.70e-05	0.07470	2.54e-02	0.070300	6.11e-02	2.19e-07
G alpha (12/13) signalling events	74	5.25e-01	7.07e-01	0.07420	-7.42e-02	0.000371	2.69e-01	9.96e-01
Vasopressin regulates renal water homeostasis via Aquaporins	42	6.72e-01	8.11e-01	0.07420	-7.27e-02	0.014800	4.15e-01	8.68e-01
Peptide hormone metabolism	83	5.28e-01	7.08e-01	0.07420	-7.17e-02	-0.018800	2.58e-01	7.67e-01
Peptide ligand-binding receptors	190	1.41e-01	3.27e-01	0.07350	5.79e-02	-0.045300	1.68e-01	2.82e-01
Cargo trafficking to the periciliary membrane	49	6.53e-01	8.01e-01	0.07340	7.33e-02	-0.003890	3.75e-01	9.62e-01
RAC3 GTPase cycle	84	4.63e-01	6.68e-01	0.07320	-7.18e-02	0.014300	2.55e-01	8.20e-01
FCGR3A-mediated IL10 synthesis	37	7.35e-01	8.55e-01	0.07300	-1.64e-03	-0.072900	9.86e-01	4.43e-01
Fcgamma receptor (FCGR) dependent phagocytosis	82	5.77e-01	7.47e-01	0.07290	3.72e-02	0.062700	5.60e-01	3.26e-01
Interleukin-27 signaling	11	8.96e-01	9.36e-01	0.07230	6.02e-02	-0.040200	7.30e-01	8.18e-01
Vesicle-mediated transport	623	3.09e-03	1.88e-02	0.07220	-2.65e-02	0.067100	2.57e-01	4.14e-03
Rap1 signalling	16	8.68e-01	9.18e-01	0.07200	-1.26e-02	0.070900	9.31e-01	6.23e-01
Hyaluronan uptake and degradation	12	9.26e-01	9.56e-01	0.07180	5.85e-02	0.041600	7.26e-01	8.03e-01
Phase 4 - resting membrane potential	19	8.41e-01	9.03e-01	0.07150	2.16e-02	-0.068200	8.71e-01	6.07e-01
Platelet homeostasis	85	5.88e-01	7.53e-01	0.07120	-5.61e-02	-0.043900	3.71e-01	4.84e-01
G beta:gamma signalling through CDC42	19	8.34e-01	9.01e-01	0.07120	-3.46e-02	0.062300	7.94e-01	6.38e-01
Glycosaminoglycan metabolism	116	3.48e-01	5.64e-01	0.07080	-6.60e-02	0.025600	2.19e-01	6.33e-01
Signaling by Retinoic Acid	41	7.05e-01	8.36e-01	0.07060	-1.29e-02	0.069500	8.87e-01	4.41e-01
Signaling by Insulin receptor	77	5.17e-01	7.04e-01	0.07040	-1.57e-02	0.068600	8.12e-01	2.98e-01
Glycogen metabolism	22	8.24e-01	8.98e-01	0.06980	-2.28e-02	0.066000	8.53e-01	5.92e-01
Nuclear signaling by ERBB4	32	7.82e-01	8.74e-01	0.06910	3.22e-03	-0.069100	9.75e-01	4.99e-01
Cargo recognition for clathrin-mediated endocytosis	98	5.67e-01	7.43e-01	0.06890	4.80e-02	0.049500	4.12e-01	3.97e-01
Leishmania infection	156	3.58e-01	5.73e-01	0.06820	1.52e-02	0.066500	7.43e-01	1.52e-01
Phase 2 - plateau phase	14	8.87e-01	9.31e-01	0.06810	6.20e-02	-0.028200	6.88e-01	8.55e-01
Biological oxidations	213	2.96e-01	5.16e-01	0.06790	-3.80e-02	-0.056200	3.38e-01	1.57e-01
Sulfur amino acid metabolism	27	8.50e-01	9.07e-01	0.06780	2.83e-02	0.061700	7.99e-01	5.79e-01
Neurotoxicity of clostridium toxins	10	9.45e-01	9.66e-01	0.06770	5.09e-02	0.044600	7.80e-01	8.07e-01
COPI-independent Golgi-to-ER retrograde traffic	34	7.47e-01	8.60e-01	0.06760	5.96e-02	-0.032000	5.48e-01	7.47e-01
RUNX2 regulates bone development	29	8.40e-01	9.03e-01	0.06760	2.69e-02	0.062100	8.02e-01	5.63e-01
Interferon gamma signaling	89	5.97e-01	7.59e-01	0.06760	3.33e-02	0.058800	5.87e-01	3.37e-01
Presynaptic function of Kainate receptors	21	8.57e-01	9.12e-01	0.06720	-6.71e-02	0.003910	5.94e-01	9.75e-01
CaM pathway	33	8.34e-01	9.01e-01	0.06690	-4.46e-02	-0.049900	6.57e-01	6.20e-01
Calmodulin induced events	33	8.34e-01	9.01e-01	0.06690	-4.46e-02	-0.049900	6.57e-01	6.20e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	603	6.96e-03	3.59e-02	0.06650	-3.67e-02	0.055400	1.23e-01	1.98e-02
Signaling by Rho GTPases	589	8.48e-03	4.16e-02	0.06560	-4.08e-02	0.051300	8.98e-02	3.30e-02
IGF1R signaling cascade	51	6.61e-01	8.05e-01	0.06530	-3.56e-02	0.054800	6.60e-01	4.98e-01
Circadian Clock	69	5.70e-01	7.43e-01	0.06490	-4.44e-02	0.047400	5.24e-01	4.96e-01
Signaling by Nuclear Receptors	237	1.64e-01	3.58e-01	0.06490	-2.44e-02	0.060100	5.17e-01	1.10e-01
Post-translational modification: synthesis of GPI-anchored proteins	89	5.18e-01	7.04e-01	0.06470	1.80e-02	-0.062100	7.68e-01	3.11e-01
eNOS activation	11	9.43e-01	9.65e-01	0.06460	-3.25e-02	-0.055800	8.52e-01	7.49e-01
Kinesins	42	7.80e-01	8.74e-01	0.06460	-6.28e-02	-0.015100	4.81e-01	8.65e-01
Signaling by Receptor Tyrosine Kinases	493	3.18e-02	1.16e-01	0.06450	-1.23e-02	0.063300	6.39e-01	1.59e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	8.05e-01	8.82e-01	0.06430	-2.17e-02	0.060500	8.40e-01	5.72e-01
Signaling by Non-Receptor Tyrosine Kinases	55	6.50e-01	8.01e-01	0.06390	-5.22e-02	0.037000	5.03e-01	6.35e-01
Signaling by PTK6	55	6.50e-01	8.01e-01	0.06390	-5.22e-02	0.037000	5.03e-01	6.35e-01
Glycogen storage diseases	14	9.32e-01	9.59e-01	0.06380	4.95e-02	0.040300	7.49e-01	7.94e-01
Surfactant metabolism	28	8.05e-01	8.82e-01	0.06340	-4.94e-02	0.039600	6.51e-01	7.17e-01
CDC42 GTPase cycle	143	3.84e-01	5.94e-01	0.06260	-6.13e-02	0.012400	2.05e-01	7.97e-01
CTLA4 inhibitory signaling	21	8.66e-01	9.17e-01	0.06250	-6.04e-02	0.015900	6.32e-01	9.00e-01
Transferrin endocytosis and recycling	30	7.98e-01	8.80e-01	0.06240	-4.32e-02	0.045000	6.82e-01	6.70e-01
Assembly and cell surface presentation of NMDA receptors	23	8.94e-01	9.35e-01	0.06190	-3.13e-02	-0.053400	7.95e-01	6.57e-01
DARPP-32 events	24	8.46e-01	9.07e-01	0.06180	-2.29e-02	0.057400	8.46e-01	6.27e-01
Serotonin Neurotransmitter Release Cycle	16	9.22e-01	9.53e-01	0.06170	-5.73e-02	-0.022800	6.92e-01	8.74e-01
Signaling by GPCR	670	4.50e-02	1.50e-01	0.06100	-5.34e-02	-0.029400	1.82e-02	1.93e-01
Anchoring of the basal body to the plasma membrane	92	5.76e-01	7.47e-01	0.06050	-5.27e-03	0.060300	9.30e-01	3.17e-01
Vitamin D (calciferol) metabolism	12	9.32e-01	9.59e-01	0.06050	-6.05e-02	0.001340	7.17e-01	9.94e-01
DAP12 signaling	28	8.26e-01	8.99e-01	0.06040	-5.33e-02	0.028400	6.26e-01	7.95e-01
Amyloid fiber formation	53	7.49e-01	8.60e-01	0.06020	5.99e-02	0.005940	4.51e-01	9.40e-01
Negative regulation of the PI3K/AKT network	111	4.69e-01	6.71e-01	0.05990	-3.34e-02	0.049700	5.43e-01	3.65e-01
IRS-mediated signalling	47	7.23e-01	8.45e-01	0.05980	-3.73e-02	0.046800	6.59e-01	5.79e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	52	7.00e-01	8.34e-01	0.05970	-4.72e-02	0.036600	5.56e-01	6.48e-01
Peptide hormone biosynthesis	11	9.27e-01	9.57e-01	0.05960	-4.29e-02	0.041300	8.05e-01	8.12e-01
Intra-Golgi traffic	43	7.80e-01	8.74e-01	0.05880	-7.35e-03	0.058400	9.34e-01	5.08e-01
Chondroitin sulfate/dermatan sulfate metabolism	45	7.43e-01	8.59e-01	0.05870	-3.48e-02	0.047300	6.87e-01	5.83e-01
Adenylate cyclase inhibitory pathway	14	9.40e-01	9.65e-01	0.05830	-2.62e-02	-0.052000	8.65e-01	7.36e-01
Ephrin signaling	17	9.08e-01	9.43e-01	0.05810	-5.73e-02	0.009380	6.83e-01	9.47e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	8.34e-01	9.01e-01	0.05770	-5.33e-02	-0.022000	5.55e-01	8.07e-01
SLC-mediated transmembrane transport	238	2.58e-01	4.73e-01	0.05750	1.32e-02	-0.055900	7.25e-01	1.37e-01
Nicotinate metabolism	29	8.58e-01	9.12e-01	0.05720	5.71e-02	-0.002870	5.94e-01	9.79e-01
Fatty acyl-CoA biosynthesis	36	8.27e-01	8.99e-01	0.05720	3.07e-03	-0.057100	9.75e-01	5.53e-01
Activation of GABAB receptors	43	8.36e-01	9.01e-01	0.05660	-2.42e-02	-0.051100	7.84e-01	5.62e-01
GABA B receptor activation	43	8.36e-01	9.01e-01	0.05660	-2.42e-02	-0.051100	7.84e-01	5.62e-01
Signaling by RAF1 mutants	37	7.98e-01	8.80e-01	0.05640	-3.31e-02	0.045600	7.28e-01	6.31e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	8.00e-01	8.80e-01	0.05630	-1.13e-02	0.055100	9.00e-01	5.41e-01
Signaling by RAS mutants	41	8.00e-01	8.80e-01	0.05630	-1.13e-02	0.055100	9.00e-01	5.41e-01
Signaling by moderate kinase activity BRAF mutants	41	8.00e-01	8.80e-01	0.05630	-1.13e-02	0.055100	9.00e-01	5.41e-01
Signaling downstream of RAS mutants	41	8.00e-01	8.80e-01	0.05630	-1.13e-02	0.055100	9.00e-01	5.41e-01
Insulin receptor signalling cascade	53	7.41e-01	8.59e-01	0.05620	-1.74e-02	0.053400	8.26e-01	5.01e-01
Aflatoxin activation and detoxification	19	9.21e-01	9.53e-01	0.05570	-1.51e-02	-0.053600	9.09e-01	6.86e-01
Activation of G protein gated Potassium channels	29	8.89e-01	9.31e-01	0.05570	-2.32e-02	-0.050600	8.29e-01	6.37e-01
G protein gated Potassium channels	29	8.89e-01	9.31e-01	0.05570	-2.32e-02	-0.050600	8.29e-01	6.37e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	29	8.89e-01	9.31e-01	0.05570	-2.32e-02	-0.050600	8.29e-01	6.37e-01
EPHB-mediated forward signaling	34	8.54e-01	9.10e-01	0.05540	5.37e-03	0.055100	9.57e-01	5.78e-01
Glycogen synthesis	13	9.43e-01	9.65e-01	0.05510	5.46e-02	0.007370	7.33e-01	9.63e-01
Signal attenuation	10	9.55e-01	9.73e-01	0.05500	4.34e-03	0.054800	9.81e-01	7.64e-01
RET signaling	41	7.90e-01	8.78e-01	0.05500	-4.57e-02	0.030600	6.13e-01	7.35e-01
Deadenylation-dependent mRNA decay	56	8.14e-01	8.90e-01	0.05470	4.09e-02	0.036400	5.97e-01	6.37e-01
Striated Muscle Contraction	33	8.84e-01	9.30e-01	0.05470	-2.94e-02	-0.046100	7.70e-01	6.47e-01
Cell death signalling via NRAGE, NRIF and NADE	69	7.80e-01	8.74e-01	0.05430	4.07e-02	0.035900	5.58e-01	6.06e-01
GPCR ligand binding	443	2.05e-01	4.02e-01	0.05350	-4.63e-02	-0.026900	9.45e-02	3.31e-01
Formation of the beta-catenin:TCF transactivating complex	32	8.65e-01	9.16e-01	0.05330	5.33e-02	-0.001350	6.02e-01	9.89e-01
Signaling by ERBB2 KD Mutants	24	8.80e-01	9.28e-01	0.05260	-3.46e-02	0.039600	7.69e-01	7.37e-01
Signaling by ERBB4	57	8.23e-01	8.98e-01	0.05250	3.07e-02	0.042500	6.88e-01	5.78e-01
IRS-related events triggered by IGF1R	50	7.67e-01	8.69e-01	0.05240	-3.65e-02	0.037600	6.56e-01	6.45e-01
Interleukin-15 signaling	13	9.55e-01	9.73e-01	0.05240	4.63e-02	0.024500	7.73e-01	8.78e-01
Transport of small molecules	689	5.71e-02	1.77e-01	0.05230	-1.56e-03	-0.052300	9.44e-01	1.90e-02
Regulation of pyruvate dehydrogenase (PDH) complex	14	9.42e-01	9.65e-01	0.05190	5.19e-02	-0.000172	7.37e-01	9.99e-01
Post NMDA receptor activation events	58	7.81e-01	8.74e-01	0.05170	-5.17e-02	0.001160	4.96e-01	9.88e-01
Activation of kainate receptors upon glutamate binding	29	9.11e-01	9.45e-01	0.05120	-3.88e-02	-0.033500	7.18e-01	7.55e-01
RAF activation	33	8.50e-01	9.07e-01	0.05100	-2.55e-02	0.044200	8.00e-01	6.60e-01
CD28 dependent PI3K/Akt signaling	22	9.03e-01	9.38e-01	0.05100	-4.85e-02	0.015900	6.94e-01	8.97e-01
Cilium Assembly	174	5.19e-01	7.04e-01	0.05070	7.47e-03	0.050200	8.65e-01	2.53e-01
RHO GTPases activate PKNs	34	8.49e-01	9.07e-01	0.05010	-3.01e-02	0.040100	7.61e-01	6.86e-01
DAP12 interactions	40	8.82e-01	9.29e-01	0.04950	-4.33e-02	-0.023900	6.35e-01	7.94e-01
Transcriptional Regulation by NPAS4	33	8.77e-01	9.26e-01	0.04890	4.86e-02	-0.005750	6.29e-01	9.54e-01
Nucleotide catabolism	35	8.80e-01	9.28e-01	0.04840	-4.84e-02	-0.001650	6.20e-01	9.87e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	104	6.59e-01	8.03e-01	0.04820	-1.08e-02	0.046900	8.50e-01	4.08e-01
Activation of NMDA receptors and postsynaptic events	69	7.96e-01	8.80e-01	0.04770	-4.70e-02	-0.008450	5.00e-01	9.03e-01
PI-3K cascade:FGFR4	19	9.49e-01	9.69e-01	0.04750	3.34e-02	0.033800	8.01e-01	7.99e-01
The canonical retinoid cycle in rods (twilight vision)	23	9.37e-01	9.63e-01	0.04740	-3.96e-02	-0.026000	7.42e-01	8.29e-01
Metabolism of water-soluble vitamins and cofactors	118	7.04e-01	8.35e-01	0.04700	1.60e-02	0.044200	7.64e-01	4.07e-01
Diseases of metabolism	234	5.01e-01	6.92e-01	0.04680	-4.43e-02	-0.015100	2.43e-01	6.91e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	38	8.89e-01	9.31e-01	0.04670	1.08e-02	0.045500	9.09e-01	6.27e-01
Late SARS-CoV-2 Infection Events	67	7.57e-01	8.65e-01	0.04670	-2.61e-02	0.038700	7.12e-01	5.83e-01
RHOA GTPase cycle	140	5.69e-01	7.43e-01	0.04610	-3.86e-02	0.025300	4.31e-01	6.06e-01
Voltage gated Potassium channels	42	8.48e-01	9.07e-01	0.04600	-2.05e-02	0.041200	8.18e-01	6.44e-01
VxPx cargo-targeting to cilium	20	9.43e-01	9.65e-01	0.04590	-1.18e-02	-0.044300	9.27e-01	7.31e-01
Repression of WNT target genes	13	9.49e-01	9.69e-01	0.04550	3.56e-02	-0.028400	8.24e-01	8.59e-01
Downregulation of TGF-beta receptor signaling	26	9.26e-01	9.56e-01	0.04530	8.61e-03	0.044400	9.39e-01	6.95e-01
p75 NTR receptor-mediated signalling	89	8.05e-01	8.82e-01	0.04400	3.76e-02	0.022800	5.39e-01	7.10e-01
Platelet degranulation	115	7.46e-01	8.60e-01	0.04260	-4.13e-02	-0.010300	4.44e-01	8.48e-01
Neuronal System	371	4.48e-01	6.57e-01	0.04230	-2.77e-02	-0.031900	3.58e-01	2.91e-01
Sialic acid metabolism	33	9.28e-01	9.57e-01	0.04180	1.82e-02	0.037600	8.56e-01	7.09e-01
Gluconeogenesis	32	9.20e-01	9.53e-01	0.04170	4.77e-03	0.041500	9.63e-01	6.85e-01
Semaphorin interactions	61	8.49e-01	9.07e-01	0.04150	1.39e-03	0.041500	9.85e-01	5.75e-01
Signal Transduction	2409	1.28e-03	8.96e-03	0.04080	-1.59e-02	0.037500	1.97e-01	2.40e-03
Tandem pore domain potassium channels	12	9.76e-01	9.84e-01	0.04070	2.84e-02	0.029200	8.65e-01	8.61e-01
PI3K/AKT Signaling in Cancer	103	7.60e-01	8.67e-01	0.03990	-5.42e-03	0.039600	9.24e-01	4.88e-01
PKA-mediated phosphorylation of CREB	19	9.58e-01	9.75e-01	0.03990	-3.89e-02	-0.009130	7.69e-01	9.45e-01
Potassium Channels	102	8.28e-01	8.99e-01	0.03900	-2.78e-02	-0.027300	6.27e-01	6.33e-01
MicroRNA (miRNA) biogenesis	26	9.30e-01	9.58e-01	0.03880	-1.58e-02	0.035500	8.89e-01	7.54e-01
Signaling by TGFB family members	118	8.01e-01	8.80e-01	0.03870	3.28e-02	0.020600	5.39e-01	6.99e-01
G alpha (z) signalling events	48	8.77e-01	9.26e-01	0.03810	-3.34e-02	0.018300	6.89e-01	8.27e-01
Signaling by ERBB2 in Cancer	25	9.45e-01	9.66e-01	0.03720	-2.38e-03	0.037100	9.84e-01	7.48e-01
Physiological factors	14	9.65e-01	9.79e-01	0.03690	1.81e-02	-0.032100	9.07e-01	8.35e-01
Metabolism of vitamins and cofactors	181	7.36e-01	8.55e-01	0.03670	3.16e-02	0.018600	4.63e-01	6.66e-01
PI3K Cascade	43	9.09e-01	9.44e-01	0.03650	-4.44e-03	0.036200	9.60e-01	6.81e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	181	7.55e-01	8.65e-01	0.03540	2.03e-02	0.029000	6.37e-01	5.01e-01
Developmental Biology	1027	2.05e-01	4.02e-01	0.03530	3.13e-02	0.016400	8.87e-02	3.71e-01
COPI-dependent Golgi-to-ER retrograde traffic	81	8.36e-01	9.01e-01	0.03440	-1.63e-02	0.030200	7.99e-01	6.38e-01
Acetylcholine Neurotransmitter Release Cycle	16	9.65e-01	9.79e-01	0.03410	2.90e-02	-0.017900	8.41e-01	9.01e-01
Frs2-mediated activation	12	9.74e-01	9.84e-01	0.03370	2.75e-02	-0.019400	8.69e-01	9.07e-01
PKA activation in glucagon signalling	17	9.75e-01	9.84e-01	0.03350	-3.03e-02	-0.014500	8.29e-01	9.18e-01
RHOD GTPase cycle	48	9.14e-01	9.48e-01	0.03320	-3.28e-02	0.005450	6.94e-01	9.48e-01
HS-GAG degradation	18	9.71e-01	9.83e-01	0.03240	7.65e-04	0.032300	9.96e-01	8.12e-01
Amino acid transport across the plasma membrane	30	9.41e-01	9.65e-01	0.03230	2.40e-02	-0.021500	8.20e-01	8.39e-01
Adrenaline,noradrenaline inhibits insulin secretion	28	9.64e-01	9.79e-01	0.03220	-1.74e-02	-0.027100	8.73e-01	8.04e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	16	9.75e-01	9.84e-01	0.03170	1.32e-03	0.031600	9.93e-01	8.27e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	9.85e-01	9.89e-01	0.02950	-1.04e-02	-0.027600	9.48e-01	8.63e-01
Response to elevated platelet cytosolic Ca2+	120	8.59e-01	9.13e-01	0.02880	-2.87e-02	-0.001870	5.87e-01	9.72e-01
Glycerophospholipid biosynthesis	114	8.63e-01	9.16e-01	0.02790	-2.76e-02	0.003500	6.10e-01	9.49e-01
SLC transporter disorders	92	9.02e-01	9.38e-01	0.02780	4.81e-03	0.027400	9.36e-01	6.50e-01
Uptake and actions of bacterial toxins	29	9.58e-01	9.75e-01	0.02760	2.07e-02	-0.018300	8.47e-01	8.64e-01
RHO GTPases Activate ROCKs	19	9.75e-01	9.84e-01	0.02650	1.63e-02	-0.020900	9.02e-01	8.74e-01
Ion homeostasis	50	9.58e-01	9.75e-01	0.02650	-1.92e-02	-0.018200	8.14e-01	8.23e-01
Trafficking of GluR2-containing AMPA receptors	15	9.80e-01	9.86e-01	0.02650	1.33e-02	-0.022900	9.29e-01	8.78e-01
Constitutive Signaling by Aberrant PI3K in Cancer	77	9.34e-01	9.60e-01	0.02490	4.95e-03	0.024400	9.40e-01	7.11e-01
Neurotransmitter receptors and postsynaptic signal transmission	175	8.45e-01	9.07e-01	0.02490	-2.49e-02	-0.000632	5.70e-01	9.88e-01
Platelet calcium homeostasis	27	9.69e-01	9.82e-01	0.02480	-2.16e-02	0.012200	8.46e-01	9.13e-01
Metabolism of lipids	696	4.80e-01	6.78e-01	0.02420	-2.18e-02	0.010400	3.25e-01	6.41e-01
PIWI-interacting RNA (piRNA) biogenesis	29	9.75e-01	9.84e-01	0.02360	2.36e-02	-0.000603	8.26e-01	9.96e-01
Meiotic recombination	26	9.83e-01	9.89e-01	0.02150	-6.15e-03	-0.020600	9.57e-01	8.56e-01
Mitochondrial calcium ion transport	22	9.88e-01	9.90e-01	0.02120	1.16e-02	0.017700	9.25e-01	8.86e-01
Dopamine Neurotransmitter Release Cycle	20	9.87e-01	9.90e-01	0.02100	-2.09e-02	-0.002740	8.72e-01	9.83e-01
Interleukin-2 family signaling	40	9.79e-01	9.85e-01	0.02100	-1.38e-02	-0.015800	8.80e-01	8.62e-01
PKA activation	18	9.89e-01	9.91e-01	0.02050	-5.23e-03	-0.019800	9.69e-01	8.84e-01
Norepinephrine Neurotransmitter Release Cycle	16	9.93e-01	9.94e-01	0.01770	-1.63e-02	-0.007050	9.10e-01	9.61e-01
Diseases of carbohydrate metabolism	30	9.87e-01	9.90e-01	0.01540	-7.67e-03	0.013400	9.42e-01	8.99e-01
Transport of bile salts and organic acids, metal ions and amine compounds	84	9.70e-01	9.82e-01	0.01440	4.06e-03	-0.013800	9.49e-01	8.27e-01
Costimulation by the CD28 family	65	9.78e-01	9.85e-01	0.01340	9.17e-03	-0.009810	8.98e-01	8.91e-01
Golgi-to-ER retrograde transport	115	9.74e-01	9.84e-01	0.01330	6.16e-03	0.011800	9.09e-01	8.26e-01
Transmission across Chemical Synapses	237	9.60e-01	9.76e-01	0.01140	-1.05e-02	-0.004450	7.80e-01	9.06e-01
Class A/1 (Rhodopsin-like receptors)	311	9.29e-01	9.58e-01	0.01110	8.08e-03	-0.007640	8.06e-01	8.17e-01
Transport of vitamins, nucleosides, and related molecules	38	9.93e-01	9.94e-01	0.01060	1.33e-03	-0.010500	9.89e-01	9.11e-01
TGF-beta receptor signaling activates SMADs	45	9.94e-01	9.94e-01	0.00892	8.33e-03	-0.003190	9.23e-01	9.70e-01

---

Detailed Gene set reports

Class C/3 (Metabotropic glutamate/pheromone receptors)

Class C/3 (Metabotropic glutamate/pheromone receptors)

metric	value
setSize	39
pMANOVA	1.33e-10
p.adjustMANOVA	4.66e-09
s.dist	0.689
s.bl	-0.526
s.gu	-0.445
p.bl	1.29e-08
p.gu	1.49e-06

Top 20 genes

Gene	bl	gu
TAS2R1	-20622	-17254
TAS2R30	-20349	-17048
TAS2R43	-19506	-17735
TAS2R20	-20843	-16146
TAS2R42	-20848	-16093
TAS2R39	-20436	-16166
TAS2R8	-20815	-15843
TAS2R9	-20449	-16060
TAS2R14	-20401	-15992
TAS2R10	-20808	-15531
TAS2R3	-20588	-15670
TAS2R50	-20655	-15542
TAS2R7	-20985	-14249
TAS2R19	-16709	-17435
TAS2R60	-17911	-16159
TAS2R4	-15734	-17801
TAS2R41	-17057	-15997
TAS2R16	-19868	-13499
GPRC6A	-20105	-12531
GRM5	-13515	-14261

Click HERE to show all gene set members

All member genes

	bl	gu
CASR	-12798	-7631
GABBR1	-9623	-8776
GABBR2	-4966	-3916
GPRC6A	-20105	-12531
GRM1	-15782	-11542
GRM2	-7185	2484
GRM3	-11590	-13657
GRM4	-6548	-5884
GRM5	-13515	-14261
GRM6	-10440	-10292
GRM7	-9547	-9894
GRM8	-2842	-12790
TAS1R1	-6476	-13299
TAS1R2	-3439	-222
TAS1R3	-8432	4321
TAS2R1	-20622	-17254
TAS2R10	-20808	-15531
TAS2R13	-16276	4054
TAS2R14	-20401	-15992
TAS2R16	-19868	-13499
TAS2R19	-16709	-17435
TAS2R20	-20843	-16146
TAS2R3	-20588	-15670
TAS2R30	-20349	-17048
TAS2R31	-19199	-3717
TAS2R38	-13472	-9265
TAS2R39	-20436	-16166
TAS2R4	-15734	-17801
TAS2R40	-16822	1556
TAS2R41	-17057	-15997
TAS2R42	-20848	-16093
TAS2R43	-19506	-17735
TAS2R46	-19962	1261
TAS2R5	-13596	-8572
TAS2R50	-20655	-15542
TAS2R60	-17911	-16159
TAS2R7	-20985	-14249
TAS2R8	-20815	-15843
TAS2R9	-20449	-16060

---

---

Eicosanoids

Eicosanoids

metric	value
setSize	12
pMANOVA	8.41e-05
p.adjustMANOVA	0.00077
s.dist	0.669
s.bl	0.65
s.gu	-0.159
p.bl	9.59e-05
p.gu	0.34

Top 20 genes

Gene	bl	gu
CYP4F8	3153	-17107
CYP8B1	2899	-16156
CYP4F2	2988	-14925
CYP4A22	1645	-13151
CYP4F22	1922	-2480
CYP4B1	205	-14818

Click HERE to show all gene set members

All member genes

	bl	gu
CYP4A11	3870	1221
CYP4A22	1645	-13151
CYP4B1	205	-14818
CYP4F11	-1381	-2558
CYP4F12	-1313	7038
CYP4F2	2988	-14925
CYP4F22	1922	-2480
CYP4F3	110	4267
CYP4F8	3153	-17107
CYP8B1	2899	-16156
PTGIS	-2561	-13164
TBXAS1	-13958	-4224

---

---

Scavenging of heme from plasma

Scavenging of heme from plasma

metric	value
setSize	12
pMANOVA	0.00205
p.adjustMANOVA	0.0133
s.dist	0.637
s.bl	-0.553
s.gu	-0.316
p.bl	0.000915
p.gu	0.0582

Top 20 genes

Gene	bl	gu
ALB	-20690	-16109
HBA1	-18856	-17464
JCHAIN	-16338	-17746
HBB	-20590	-13634
HPX	-19001	-11729
CD163	-18463	-9032
AMBP	-11876	-12750
APOA1	-7355	-8583
HPR	-16021	-3340
APOL1	-19296	-877

Click HERE to show all gene set members

All member genes

	bl	gu
ALB	-20690	-16109
AMBP	-11876	-12750
APOA1	-7355	-8583
APOL1	-19296	-877
CD163	-18463	-9032
HBA1	-18856	-17464
HBB	-20590	-13634
HP	-16691	918
HPR	-16021	-3340
HPX	-19001	-11729
JCHAIN	-16338	-17746
LRP1	-2759	140

---

---

Prednisone ADME

Prednisone ADME

metric	value
setSize	10
pMANOVA	0.00678
p.adjustMANOVA	0.0357
s.dist	0.63
s.bl	-0.333
s.gu	-0.534
p.bl	0.0684
p.gu	0.00343

Top 20 genes

Gene	bl	gu
UGT2B7	-20164	-16708
ALB	-20690	-16109
ABCB1	-17230	-12303
CYP3A4	-15535	-12500
UGT2B17	-20578	-8968
AKR1C1	-10541	-13832
UGT1A3	-13811	-9016
HSD11B1	-11190	-7324
HSD11B2	-1642	-6648

Click HERE to show all gene set members

All member genes

	bl	gu
ABCB1	-17230	-12303
AKR1C1	-10541	-13832
ALB	-20690	-16109
CYP3A4	-15535	-12500
HSD11B1	-11190	-7324
HSD11B2	-1642	-6648
SERPINA6	3020	-16533
UGT1A3	-13811	-9016
UGT2B17	-20578	-8968
UGT2B7	-20164	-16708

---

---

Glucuronidation

Glucuronidation

metric	value
setSize	25
pMANOVA	8.1e-06
p.adjustMANOVA	9.14e-05
s.dist	0.617
s.bl	-0.485
s.gu	-0.381
p.bl	2.72e-05
p.gu	0.000962

Top 20 genes

Gene	bl	gu
UGT2B11	-21141	-17514.0
UGT2B4	-21231	-16812.0
UGT2B7	-20164	-16708.0
UGT2B10	-21082	-15154.0
UGT2B28	-21375	-14348.0
UGT2A2	-19951	-15102.0
UGT2A3	-19429	-12501.0
UGT2B17	-20578	-8968.0
UGT2A1	-20793	-8680.0
UGT2B15	-15676	-10202.0
UGT1A1	-11834	-13300.0
UGT1A10	-13525	-10425.5
UGT3A1	-15075	-9076.0
UGT1A8	-13525	-9829.0
UGT1A7	-13525	-9432.0
SLC35D1	-15625	-8077.0
UGT1A3	-13811	-9016.0
UGT1A6	-11901	-10425.5
UGT1A5	-12793	-9016.0
UGT1A9	-12793	-9016.0

Click HERE to show all gene set members

All member genes

	bl	gu
ABHD10	-798	1174.0
SLC35D1	-15625	-8077.0
UGDH	-9189	-2183.0
UGP2	-4078	-3487.0
UGT1A1	-11834	-13300.0
UGT1A10	-13525	-10425.5
UGT1A3	-13811	-9016.0
UGT1A4	-12793	-7553.0
UGT1A5	-12793	-9016.0
UGT1A6	-11901	-10425.5
UGT1A7	-13525	-9432.0
UGT1A8	-13525	-9829.0
UGT1A9	-12793	-9016.0
UGT2A1	-20793	-8680.0
UGT2A2	-19951	-15102.0
UGT2A3	-19429	-12501.0
UGT2B10	-21082	-15154.0
UGT2B11	-21141	-17514.0
UGT2B15	-15676	-10202.0
UGT2B17	-20578	-8968.0
UGT2B28	-21375	-14348.0
UGT2B4	-21231	-16812.0
UGT2B7	-20164	-16708.0
UGT3A1	-15075	-9076.0
UGT3A2	-6919	-4957.0

---

---

SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery

metric	value
setSize	34
pMANOVA	1.07e-07
p.adjustMANOVA	2.22e-06
s.dist	0.609
s.bl	0.529
s.gu	0.301
p.bl	9.22e-08
p.gu	0.00235

Top 20 genes

Gene	bl	gu
HNRNPA1	3741.0	6223
RPS27A	2779.0	3982
RPS19	2386.0	3424
RPS12	3712.0	1981
RPSA	1158.5	3800
EEF1A1	486.0	7133
RPS17	1109.0	2983
RPS18	1884.0	929
RPS27	108.0	6831

Click HERE to show all gene set members

All member genes

	bl	gu
EEF1A1	486.0	7133.0
FAU	925.0	-3977.5
HNRNPA1	3741.0	6223.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0

---

---

Sensory perception of sweet, bitter, and umami (glutamate) taste

Sensory perception of sweet, bitter, and umami (glutamate) taste

metric	value
setSize	41
pMANOVA	1.59e-07
p.adjustMANOVA	3.03e-06
s.dist	0.555
s.bl	-0.448
s.gu	-0.329
p.bl	7.04e-07
p.gu	0.000271

Top 20 genes

Gene	bl	gu
TAS2R1	-20622	-17254
TAS2R30	-20349	-17048
GNAT3	-20925	-16539
TAS2R43	-19506	-17735
TAS2R20	-20843	-16146
TAS2R39	-20436	-16166
TAS2R8	-20815	-15843
TAS2R14	-20401	-15992
TAS2R10	-20808	-15531
TAS2R3	-20588	-15670
TAS2R50	-20655	-15542
TAS2R7	-20985	-14249
TAS2R4	-15734	-17801
TAS2R41	-17057	-15997
TAS2R16	-19868	-13499
SCN9A	-18868	-13444
GRM1	-15782	-11542
TAS2R38	-13472	-9265
ITPR3	-9888	-11907
TAS2R5	-13596	-8572

Click HERE to show all gene set members

All member genes

	bl	gu
CALHM1	-12188	-2677
CALHM3	-4746	-13693
GNAT3	-20925	-16539
GNB1	-14571	-6653
GNB3	-11537	545
GNG13	-11606	967
GRM1	-15782	-11542
GRM4	-6548	-5884
ITPR3	-9888	-11907
PLCB2	-10727	-6613
SCN1B	-12569	-5295
SCN2A	-8505	-11243
SCN2B	-8008	-502
SCN3A	-6568	-9542
SCN4B	-7359	-1722
SCN9A	-18868	-13444
TAS1R1	-6476	-13299
TAS1R2	-3439	-222
TAS1R3	-8432	4321
TAS2R1	-20622	-17254
TAS2R10	-20808	-15531
TAS2R13	-16276	4054
TAS2R14	-20401	-15992
TAS2R16	-19868	-13499
TAS2R20	-20843	-16146
TAS2R3	-20588	-15670
TAS2R30	-20349	-17048
TAS2R31	-19199	-3717
TAS2R38	-13472	-9265
TAS2R39	-20436	-16166
TAS2R4	-15734	-17801
TAS2R40	-16822	1556
TAS2R41	-17057	-15997
TAS2R43	-19506	-17735
TAS2R46	-19962	1261
TAS2R5	-13596	-8572
TAS2R50	-20655	-15542
TAS2R7	-20985	-14249
TAS2R8	-20815	-15843
TRPM4	-6659	-11180
TRPM5	-3048	-7798

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	84
pMANOVA	1.58e-14
p.adjustMANOVA	1.16e-12
s.dist	0.548
s.bl	0.468
s.gu	0.285
p.bl	1.16e-13
p.gu	6.49e-06

Top 20 genes

Gene	bl	gu
RPL35A	3401.0	6350
RPL41	3270.0	5146
RPL23	2192.0	6437
RPS27A	2779.0	3982
RPL34	2673.5	3911
RPS19	2386.0	3424
RPS12	3712.0	1981
RPSA	1158.5	3800
EEF1A1	486.0	7133
RPS17	1109.0	2983
RPL35	423.0	7570
RPS18	1884.0	929
RPS27	108.0	6831
RPL4	3510.0	124
RPL13	249.0	497

Click HERE to show all gene set members

All member genes

	bl	gu
EEF1A1	486.0	7133.0
EEF2	-6459.0	5327.0
FAU	925.0	-3977.5
RPL10A	-2725.0	1201.0
RPL10L	-17282.0	-14934.0
RPL11	-8184.0	4520.0
RPL12	-4128.0	2724.0
RPL13	249.0	497.0
RPL13A	-4766.5	-7927.5
RPL14	-1225.0	-9732.0
RPL15	-4028.0	2643.0
RPL17	398.0	-12856.0
RPL18	-152.0	6522.0
RPL18A	-498.0	-10349.0
RPL19	-4251.0	3231.0
RPL21	-2014.0	3806.0
RPL22	-6992.0	-5217.0
RPL22L1	-13316.0	-13765.0
RPL23	2192.0	6437.0
RPL23A	49.0	-3660.0
RPL24	-8846.0	4441.0
RPL26	-353.0	5155.0
RPL26L1	-2664.0	-2912.0
RPL27	-3413.0	-1641.0
RPL27A	-628.0	1877.0
RPL28	2808.0	-2646.0
RPL29	-2215.0	1142.0
RPL3	-2551.0	5035.0
RPL30	-2037.0	-7771.0
RPL31	-11010.0	537.0
RPL32	1166.0	-7362.0
RPL34	2673.5	3911.0
RPL35	423.0	7570.0
RPL35A	3401.0	6350.0
RPL36	-2802.0	-3096.0
RPL36AL	-3982.0	3938.0
RPL37	-1931.0	-8725.0
RPL37A	-2812.0	4394.0
RPL38	-10902.0	3642.0
RPL39L	1257.0	-6117.0
RPL3L	-7041.0	-16385.0
RPL4	3510.0	124.0
RPL41	3270.0	5146.0
RPL5	-366.0	-12499.0
RPL6	-5398.0	910.0
RPL7	-1160.0	5094.0
RPL7A	-1890.0	1508.5
RPL8	-1214.0	-4009.0
RPL9	-181.0	-6342.0
RPLP0	-5253.0	-3921.0
RPLP1	-12660.0	-5577.0
RPLP2	-821.0	-6905.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0
UBA52	-4599.0	1289.0

---

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	88
pMANOVA	7.71e-15
p.adjustMANOVA	6.62e-13
s.dist	0.541
s.bl	0.464
s.gu	0.278
p.bl	5.12e-14
p.gu	6.66e-06

Top 20 genes

Gene	bl	gu
RPL35A	3401.0	6350
RPL41	3270.0	5146
EEF1B2	3649.0	3917
RPL23	2192.0	6437
RPS27A	2779.0	3982
RPL34	2673.5	3911
RPS19	2386.0	3424
RPS12	3712.0	1981
RPSA	1158.5	3800
EEF1A1	486.0	7133
RPS17	1109.0	2983
RPL35	423.0	7570
RPS18	1884.0	929
RPS27	108.0	6831
RPL4	3510.0	124
RPL13	249.0	497

Click HERE to show all gene set members

All member genes

	bl	gu
EEF1A1	486.0	7133.0
EEF1A2	-6987.0	-8789.0
EEF1B2	3649.0	3917.0
EEF1D	-10748.0	-11943.0
EEF1G	-856.0	3117.0
EEF2	-6459.0	5327.0
FAU	925.0	-3977.5
RPL10A	-2725.0	1201.0
RPL10L	-17282.0	-14934.0
RPL11	-8184.0	4520.0
RPL12	-4128.0	2724.0
RPL13	249.0	497.0
RPL13A	-4766.5	-7927.5
RPL14	-1225.0	-9732.0
RPL15	-4028.0	2643.0
RPL17	398.0	-12856.0
RPL18	-152.0	6522.0
RPL18A	-498.0	-10349.0
RPL19	-4251.0	3231.0
RPL21	-2014.0	3806.0
RPL22	-6992.0	-5217.0
RPL22L1	-13316.0	-13765.0
RPL23	2192.0	6437.0
RPL23A	49.0	-3660.0
RPL24	-8846.0	4441.0
RPL26	-353.0	5155.0
RPL26L1	-2664.0	-2912.0
RPL27	-3413.0	-1641.0
RPL27A	-628.0	1877.0
RPL28	2808.0	-2646.0
RPL29	-2215.0	1142.0
RPL3	-2551.0	5035.0
RPL30	-2037.0	-7771.0
RPL31	-11010.0	537.0
RPL32	1166.0	-7362.0
RPL34	2673.5	3911.0
RPL35	423.0	7570.0
RPL35A	3401.0	6350.0
RPL36	-2802.0	-3096.0
RPL36AL	-3982.0	3938.0
RPL37	-1931.0	-8725.0
RPL37A	-2812.0	4394.0
RPL38	-10902.0	3642.0
RPL39L	1257.0	-6117.0
RPL3L	-7041.0	-16385.0
RPL4	3510.0	124.0
RPL41	3270.0	5146.0
RPL5	-366.0	-12499.0
RPL6	-5398.0	910.0
RPL7	-1160.0	5094.0
RPL7A	-1890.0	1508.5
RPL8	-1214.0	-4009.0
RPL9	-181.0	-6342.0
RPLP0	-5253.0	-3921.0
RPLP1	-12660.0	-5577.0
RPLP2	-821.0	-6905.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0
UBA52	-4599.0	1289.0

---

---

TICAM1-dependent activation of IRF3/IRF7

TICAM1-dependent activation of IRF3/IRF7

metric	value
setSize	12
pMANOVA	0.0142
p.adjustMANOVA	0.0618
s.dist	0.538
s.bl	0.368
s.gu	0.393
p.bl	0.0274
p.gu	0.0184

Top 20 genes

Gene	bl	gu
RPS27A	2779	3982
UBB	3388	1123
TLR3	3813	450
TICAM1	318	4885

Click HERE to show all gene set members

All member genes

	bl	gu
IKBKE	-456	-4044
IRF3	-5440	-2551
IRF7	-5337	2915
RPS27A	2779	3982
TANK	-13440	-2474
TBK1	-12430	-4098
TICAM1	318	4885
TLR3	3813	450
TRAF3	-14759	-1010
UBA52	-4599	1289
UBB	3388	1123
UBC	188	-1339

---

---

Aspirin ADME

Aspirin ADME

metric	value
setSize	44
pMANOVA	1.76e-07
p.adjustMANOVA	3.28e-06
s.dist	0.538
s.bl	-0.372
s.gu	-0.388
p.bl	1.92e-05
p.gu	8.43e-06

Top 20 genes

Gene	bl	gu
UGT2B11	-21141	-17514
UGT2B4	-21231	-16812
UGT2B7	-20164	-16708
ACSM2A	-19612	-17094
ALB	-20690	-16109
GLYATL3	-19734	-16645
UGT2B10	-21082	-15154
CYP2C19	-18416	-16723
UGT2B28	-21375	-14348
BCHE	-20900	-14660
UGT2A2	-19951	-15102
CYP2D6	-17750	-16931
GLYAT	-17476	-14156
UGT2A3	-19429	-12501
GLYATL2	-19966	-11724
SLC22A7	-12206	-16463
CYP3A4	-15535	-12500
UGT2B17	-20578	-8968
UGT2A1	-20793	-8680
UGT2B15	-15676	-10202

Click HERE to show all gene set members

All member genes

	bl	gu
ABCC2	-11618	-13675.0
ABCC3	-4960	-9459.0
ACSM2A	-19612	-17094.0
ACSM2B	3753	2302.0
ACSM4	698	-2769.0
ACSM5	2283	-13233.0
ALB	-20690	-16109.0
BCHE	-20900	-14660.0
BSG	-6269	1793.0
CES1	-5789	3008.0
CES2	-2808	341.0
CYP2C19	-18416	-16723.0
CYP2C8	-19894	-6182.0
CYP2C9	1685	-2047.0
CYP2D6	-17750	-16931.0
CYP2E1	-17785	-7379.0
CYP3A4	-15535	-12500.0
GLYAT	-17476	-14156.0
GLYATL1	-6569	-15756.0
GLYATL2	-19966	-11724.0
GLYATL3	-19734	-16645.0
SLC16A1	-11524	7022.0
SLC22A7	-12206	-16463.0
SLCO2B1	621	-7976.0
UGT1A1	-11834	-13300.0
UGT1A3	-13811	-9016.0
UGT1A4	-12793	-7553.0
UGT1A5	-12793	-9016.0
UGT1A6	-11901	-10425.5
UGT1A7	-13525	-9432.0
UGT1A8	-13525	-9829.0
UGT1A9	-12793	-9016.0
UGT2A1	-20793	-8680.0
UGT2A2	-19951	-15102.0
UGT2A3	-19429	-12501.0
UGT2B10	-21082	-15154.0
UGT2B11	-21141	-17514.0
UGT2B15	-15676	-10202.0
UGT2B17	-20578	-8968.0
UGT2B28	-21375	-14348.0
UGT2B4	-21231	-16812.0
UGT2B7	-20164	-16708.0
UGT3A1	-15075	-9076.0
UGT3A2	-6919	-4957.0

---

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

metric	value
setSize	87
pMANOVA	5.27e-14
p.adjustMANOVA	3.54e-12
s.dist	0.526
s.bl	0.456
s.gu	0.262
p.bl	1.83e-13
p.gu	2.34e-05

Top 20 genes

Gene	bl	gu
RPL35A	3401.0	6350
RPL41	3270.0	5146
RPL23	2192.0	6437
RPS27A	2779.0	3982
RPL34	2673.5	3911
RPS19	2386.0	3424
RPS12	3712.0	1981
RPSA	1158.5	3800
RPS17	1109.0	2983
RPL35	423.0	7570
RPS18	1884.0	929
RPS27	108.0	6831
RPL4	3510.0	124
RPL13	249.0	497

Click HERE to show all gene set members

All member genes

	bl	gu
APEH	-9934.0	-1004.0
ETF1	-5678.0	-8033.0
FAU	925.0	-3977.5
GSPT1	-8159.0	-3580.0
N6AMT1	-2789.0	-9479.0
RPL10A	-2725.0	1201.0
RPL10L	-17282.0	-14934.0
RPL11	-8184.0	4520.0
RPL12	-4128.0	2724.0
RPL13	249.0	497.0
RPL13A	-4766.5	-7927.5
RPL14	-1225.0	-9732.0
RPL15	-4028.0	2643.0
RPL17	398.0	-12856.0
RPL18	-152.0	6522.0
RPL18A	-498.0	-10349.0
RPL19	-4251.0	3231.0
RPL21	-2014.0	3806.0
RPL22	-6992.0	-5217.0
RPL22L1	-13316.0	-13765.0
RPL23	2192.0	6437.0
RPL23A	49.0	-3660.0
RPL24	-8846.0	4441.0
RPL26	-353.0	5155.0
RPL26L1	-2664.0	-2912.0
RPL27	-3413.0	-1641.0
RPL27A	-628.0	1877.0
RPL28	2808.0	-2646.0
RPL29	-2215.0	1142.0
RPL3	-2551.0	5035.0
RPL30	-2037.0	-7771.0
RPL31	-11010.0	537.0
RPL32	1166.0	-7362.0
RPL34	2673.5	3911.0
RPL35	423.0	7570.0
RPL35A	3401.0	6350.0
RPL36	-2802.0	-3096.0
RPL36AL	-3982.0	3938.0
RPL37	-1931.0	-8725.0
RPL37A	-2812.0	4394.0
RPL38	-10902.0	3642.0
RPL39L	1257.0	-6117.0
RPL3L	-7041.0	-16385.0
RPL4	3510.0	124.0
RPL41	3270.0	5146.0
RPL5	-366.0	-12499.0
RPL6	-5398.0	910.0
RPL7	-1160.0	5094.0
RPL7A	-1890.0	1508.5
RPL8	-1214.0	-4009.0
RPL9	-181.0	-6342.0
RPLP0	-5253.0	-3921.0
RPLP1	-12660.0	-5577.0
RPLP2	-821.0	-6905.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0
TRMT112	-342.0	5222.0
UBA52	-4599.0	1289.0

---

---

Selenocysteine synthesis

Selenocysteine synthesis

metric	value
setSize	87
pMANOVA	5.84e-14
p.adjustMANOVA	3.61e-12
s.dist	0.525
s.bl	0.455
s.gu	0.262
p.bl	2.01e-13
p.gu	2.42e-05

Top 20 genes

Gene	bl	gu
RPL35A	3401.0	6350
RPL41	3270.0	5146
RPL23	2192.0	6437
RPS27A	2779.0	3982
RPL34	2673.5	3911
RPS19	2386.0	3424
RPS12	3712.0	1981
RPSA	1158.5	3800
RPS17	1109.0	2983
RPL35	423.0	7570
RPS18	1884.0	929
RPS27	108.0	6831
RPL4	3510.0	124
RPL13	249.0	497

Click HERE to show all gene set members

All member genes

	bl	gu
EEFSEC	-8163.0	-2661.0
FAU	925.0	-3977.5
PSTK	-3073.0	-3629.0
RPL10A	-2725.0	1201.0
RPL10L	-17282.0	-14934.0
RPL11	-8184.0	4520.0
RPL12	-4128.0	2724.0
RPL13	249.0	497.0
RPL13A	-4766.5	-7927.5
RPL14	-1225.0	-9732.0
RPL15	-4028.0	2643.0
RPL17	398.0	-12856.0
RPL18	-152.0	6522.0
RPL18A	-498.0	-10349.0
RPL19	-4251.0	3231.0
RPL21	-2014.0	3806.0
RPL22	-6992.0	-5217.0
RPL22L1	-13316.0	-13765.0
RPL23	2192.0	6437.0
RPL23A	49.0	-3660.0
RPL24	-8846.0	4441.0
RPL26	-353.0	5155.0
RPL26L1	-2664.0	-2912.0
RPL27	-3413.0	-1641.0
RPL27A	-628.0	1877.0
RPL28	2808.0	-2646.0
RPL29	-2215.0	1142.0
RPL3	-2551.0	5035.0
RPL30	-2037.0	-7771.0
RPL31	-11010.0	537.0
RPL32	1166.0	-7362.0
RPL34	2673.5	3911.0
RPL35	423.0	7570.0
RPL35A	3401.0	6350.0
RPL36	-2802.0	-3096.0
RPL36AL	-3982.0	3938.0
RPL37	-1931.0	-8725.0
RPL37A	-2812.0	4394.0
RPL38	-10902.0	3642.0
RPL39L	1257.0	-6117.0
RPL3L	-7041.0	-16385.0
RPL4	3510.0	124.0
RPL41	3270.0	5146.0
RPL5	-366.0	-12499.0
RPL6	-5398.0	910.0
RPL7	-1160.0	5094.0
RPL7A	-1890.0	1508.5
RPL8	-1214.0	-4009.0
RPL9	-181.0	-6342.0
RPLP0	-5253.0	-3921.0
RPLP1	-12660.0	-5577.0
RPLP2	-821.0	-6905.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0
SECISBP2	-11432.0	-5569.0
SEPHS2	-5072.0	-2772.0
SEPSECS	-27.0	-2729.0
UBA52	-4599.0	1289.0

---

---

Viral mRNA Translation

Viral mRNA Translation

metric	value
setSize	84
pMANOVA	3.14e-13
p.adjustMANOVA	1.67e-11
s.dist	0.522
s.bl	0.445
s.gu	0.272
p.bl	1.74e-12
p.gu	1.61e-05

Top 20 genes

Gene	bl	gu
RPL35A	3401.0	6350
RPL41	3270.0	5146
RPL23	2192.0	6437
RPS27A	2779.0	3982
RPL34	2673.5	3911
RPS19	2386.0	3424
RPS12	3712.0	1981
RPSA	1158.5	3800
RPS17	1109.0	2983
RPL35	423.0	7570
RPS18	1884.0	929
RPS27	108.0	6831
RPL4	3510.0	124
RPL13	249.0	497

Click HERE to show all gene set members

All member genes

	bl	gu
DNAJC3	-15396.0	1469.0
FAU	925.0	-3977.5
GRSF1	-15459.0	-2336.0
RPL10A	-2725.0	1201.0
RPL10L	-17282.0	-14934.0
RPL11	-8184.0	4520.0
RPL12	-4128.0	2724.0
RPL13	249.0	497.0
RPL13A	-4766.5	-7927.5
RPL14	-1225.0	-9732.0
RPL15	-4028.0	2643.0
RPL17	398.0	-12856.0
RPL18	-152.0	6522.0
RPL18A	-498.0	-10349.0
RPL19	-4251.0	3231.0
RPL21	-2014.0	3806.0
RPL22	-6992.0	-5217.0
RPL22L1	-13316.0	-13765.0
RPL23	2192.0	6437.0
RPL23A	49.0	-3660.0
RPL24	-8846.0	4441.0
RPL26	-353.0	5155.0
RPL26L1	-2664.0	-2912.0
RPL27	-3413.0	-1641.0
RPL27A	-628.0	1877.0
RPL28	2808.0	-2646.0
RPL29	-2215.0	1142.0
RPL3	-2551.0	5035.0
RPL30	-2037.0	-7771.0
RPL31	-11010.0	537.0
RPL32	1166.0	-7362.0
RPL34	2673.5	3911.0
RPL35	423.0	7570.0
RPL35A	3401.0	6350.0
RPL36	-2802.0	-3096.0
RPL36AL	-3982.0	3938.0
RPL37	-1931.0	-8725.0
RPL37A	-2812.0	4394.0
RPL38	-10902.0	3642.0
RPL39L	1257.0	-6117.0
RPL3L	-7041.0	-16385.0
RPL4	3510.0	124.0
RPL41	3270.0	5146.0
RPL5	-366.0	-12499.0
RPL6	-5398.0	910.0
RPL7	-1160.0	5094.0
RPL7A	-1890.0	1508.5
RPL8	-1214.0	-4009.0
RPL9	-181.0	-6342.0
RPLP0	-5253.0	-3921.0
RPLP1	-12660.0	-5577.0
RPLP2	-821.0	-6905.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0
UBA52	-4599.0	1289.0

---

---

PINK1-PRKN Mediated Mitophagy

PINK1-PRKN Mediated Mitophagy

metric	value
setSize	21
pMANOVA	0.00106
p.adjustMANOVA	0.0078
s.dist	0.516
s.bl	0.348
s.gu	0.382
p.bl	0.00581
p.gu	0.00246

Top 20 genes

Gene	bl	gu
TOMM40	2415	6290
RPS27A	2779	3982
MFN1	2589	2907
UBB	3388	1123

Click HERE to show all gene set members

All member genes

	bl	gu
ATG12	-8297	-9286
ATG5	-11153	-1036
MAP1LC3A	-9396	3014
MAP1LC3B	-9320	5152
MFN1	2589	2907
MFN2	-2382	3794
MTERF3	2822	-3331
PARK2	-6751	-10836
PINK1	-6017	5689
RPS27A	2779	3982
SQSTM1	-8373	3979
TOMM20	-3644	2371
TOMM22	-1905	-5663
TOMM40	2415	6290
TOMM5	-11708	-5133
TOMM6	2452	-1322
TOMM7	-3185	-2887
UBA52	-4599	1289
UBB	3388	1123
UBC	188	-1339
VDAC1	-15839	-3429

---

---

Pexophagy

Pexophagy

metric	value
setSize	11
pMANOVA	0.0264
p.adjustMANOVA	0.1
s.dist	0.516
s.bl	0.42
s.gu	0.299
p.bl	0.0159
p.gu	0.086

Top 20 genes

Gene	bl	gu
RPS27A	2779	3982
UBB	3388	1123

Click HERE to show all gene set members

All member genes

	bl	gu
ATM	2590	-3415
EPAS1	-10957	-9288
MAP1LC3B	-9320	5152
NBR1	2327	-6166
PEX5	-8488	676
RPS27A	2779	3982
SQSTM1	-8373	3979
UBA52	-4599	1289
UBB	3388	1123
UBC	188	-1339
USP30	-4299	-10109

---

---

TICAM1,TRAF6-dependent induction of TAK1 complex

TICAM1,TRAF6-dependent induction of TAK1 complex

metric	value
setSize	10
pMANOVA	0.0387
p.adjustMANOVA	0.134
s.dist	0.515
s.bl	0.348
s.gu	0.38
p.bl	0.057
p.gu	0.0372

Top 20 genes

Gene	bl	gu
RPS27A	2779	3982
UBB	3388	1123
TLR3	3813	450
TICAM1	318	4885

Click HERE to show all gene set members

All member genes

	bl	gu
MAP3K7	-9651	-9493
RPS27A	2779	3982
TAB1	-11309	5319
TAB2	-11796	-9352
TICAM1	318	4885
TLR3	3813	450
TRAF6	-14050	774
UBA52	-4599	1289
UBB	3388	1123
UBC	188	-1339

---

---

SCF(Skp2)-mediated degradation of p27/p21

SCF(Skp2)-mediated degradation of p27/p21

metric	value
setSize	58
pMANOVA	9.06e-09
p.adjustMANOVA	2.5e-07
s.dist	0.511
s.bl	0.355
s.gu	0.368
p.bl	2.91e-06
p.gu	1.25e-06

Top 20 genes

Gene	bl	gu
PSMC2	3803	6031
CKS1B	2701	6695
PSMD7	2498	6265
PSMA5	2585	5285
RPS27A	2779	3982
CDK4	2873	2806
PSME1	1078	7207
PSMD3	1361	5234
SKP1	1474	4634
PSMD4	2353	1690
UBB	3388	1123
PSMC4	2132	1280

Click HERE to show all gene set members

All member genes

	bl	gu
CCNA1	-10926.0	-1832
CCNA2	-118.0	-26
CCND1	-8891.0	-12
CCNE1	-15507.0	303
CCNE2	-7615.0	5605
CDK2	-7142.0	-2291
CDK4	2873.0	2806
CDKN1A	-4543.0	4884
CDKN1B	-1471.0	3198
CKS1B	2701.0	6695
CUL1	-15085.0	-7180
PSMA1	-3412.0	3959
PSMA2	1412.0	-6569
PSMA3	-228.0	2621
PSMA4	-1743.0	-555
PSMA5	2585.0	5285
PSMA6	-6674.0	3459
PSMA7	-4079.0	6186
PSMB1	469.0	-7922
PSMB10	-11837.0	-4265
PSMB2	-6922.0	3968
PSMB3	-3000.0	-1468
PSMB4	-371.0	-15631
PSMB5	-4730.0	-8797
PSMB6	-8722.0	-5248
PSMB7	-9915.0	5802
PSMB8	-716.0	-5924
PSMB9	1092.0	-3360
PSMC1	-3206.0	-10570
PSMC2	3803.0	6031
PSMC3	-12761.0	4254
PSMC4	2132.0	1280
PSMC5	-1961.0	1861
PSMC6	-8378.0	6462
PSMD1	-19184.0	-10852
PSMD11	-4049.0	-3275
PSMD12	24.0	-7256
PSMD13	-2337.0	3893
PSMD14	-18126.0	-4800
PSMD2	-6559.0	2157
PSMD3	1361.0	5234
PSMD4	2353.0	1690
PSMD5	-65.5	2411
PSMD6	-17603.0	-12820
PSMD7	2498.0	6265
PSMD8	-9033.0	721
PSMD9	-12004.0	-5850
PSME1	1078.0	7207
PSME2	-464.0	2740
PSME3	1492.0	-773
PSMF1	-5127.0	-498
PTK6	-4323.0	-16269
RPS27A	2779.0	3982
SKP1	1474.0	4634
SKP2	-2600.0	3840
UBA52	-4599.0	1289
UBB	3388.0	1123
UBC	188.0	-1339

---

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

metric	value
setSize	95
pMANOVA	5.58e-14
p.adjustMANOVA	3.6e-12
s.dist	0.504
s.bl	0.435
s.gu	0.254
p.bl	2.25e-13
p.gu	1.89e-05

Top 20 genes

Gene	bl	gu
EIF2S2	3572.0	6992
RPL35A	3401.0	6350
RPL41	3270.0	5146
RPL23	2192.0	6437
RPS27A	2779.0	3982
RPL34	2673.5	3911
RPS19	2386.0	3424
RPS12	3712.0	1981
ATF4	795.0	6465
RPSA	1158.5	3800
RPS17	1109.0	2983
RPL35	423.0	7570
RPS18	1884.0	929
RPS27	108.0	6831
RPL4	3510.0	124
RPL13	249.0	497

Click HERE to show all gene set members

All member genes

	bl	gu
ASNS	-267.0	-8092.0
ATF2	1519.0	-609.0
ATF3	-3091.0	-4169.0
ATF4	795.0	6465.0
CEBPB	-8561.0	4504.0
CEBPG	-11859.0	3416.0
DDIT3	1898.0	-15808.0
EIF2AK4	-18500.0	-9280.0
EIF2S1	-8822.0	-8237.0
EIF2S2	3572.0	6992.0
FAU	925.0	-3977.5
GCN1	-13863.0	-1019.0
IMPACT	-16571.0	-14310.0
RPL10A	-2725.0	1201.0
RPL10L	-17282.0	-14934.0
RPL11	-8184.0	4520.0
RPL12	-4128.0	2724.0
RPL13	249.0	497.0
RPL13A	-4766.5	-7927.5
RPL14	-1225.0	-9732.0
RPL15	-4028.0	2643.0
RPL17	398.0	-12856.0
RPL18	-152.0	6522.0
RPL18A	-498.0	-10349.0
RPL19	-4251.0	3231.0
RPL21	-2014.0	3806.0
RPL22	-6992.0	-5217.0
RPL22L1	-13316.0	-13765.0
RPL23	2192.0	6437.0
RPL23A	49.0	-3660.0
RPL24	-8846.0	4441.0
RPL26	-353.0	5155.0
RPL26L1	-2664.0	-2912.0
RPL27	-3413.0	-1641.0
RPL27A	-628.0	1877.0
RPL28	2808.0	-2646.0
RPL29	-2215.0	1142.0
RPL3	-2551.0	5035.0
RPL30	-2037.0	-7771.0
RPL31	-11010.0	537.0
RPL32	1166.0	-7362.0
RPL34	2673.5	3911.0
RPL35	423.0	7570.0
RPL35A	3401.0	6350.0
RPL36	-2802.0	-3096.0
RPL36AL	-3982.0	3938.0
RPL37	-1931.0	-8725.0
RPL37A	-2812.0	4394.0
RPL38	-10902.0	3642.0
RPL39L	1257.0	-6117.0
RPL3L	-7041.0	-16385.0
RPL4	3510.0	124.0
RPL41	3270.0	5146.0
RPL5	-366.0	-12499.0
RPL6	-5398.0	910.0
RPL7	-1160.0	5094.0
RPL7A	-1890.0	1508.5
RPL8	-1214.0	-4009.0
RPL9	-181.0	-6342.0
RPLP0	-5253.0	-3921.0
RPLP1	-12660.0	-5577.0
RPLP2	-821.0	-6905.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0
TRIB3	-858.0	-1203.0
UBA52	-4599.0	1289.0

---

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

metric	value
setSize	89
pMANOVA	6.26e-13
p.adjustMANOVA	2.85e-11
s.dist	0.501
s.bl	0.426
s.gu	0.263
p.bl	3.56e-12
p.gu	1.75e-05

Top 20 genes

Gene	bl	gu
RPL35A	3401.0	6350
RPL41	3270.0	5146
RPL23	2192.0	6437
RPS27A	2779.0	3982
RPL34	2673.5	3911
RPS19	2386.0	3424
RPS12	3712.0	1981
RPSA	1158.5	3800
RPS17	1109.0	2983
RPL35	423.0	7570
RPS18	1884.0	929
RPS27	108.0	6831
RPL4	3510.0	124
RPL13	249.0	497

Click HERE to show all gene set members

All member genes

	bl	gu
EIF4G1	-5067.0	-3958.0
ETF1	-5678.0	-8033.0
FAU	925.0	-3977.5
GSPT1	-8159.0	-3580.0
NCBP1	-10015.0	-80.0
NCBP2	-8028.0	-2599.0
PABPC1	-19383.0	-3729.0
RPL10A	-2725.0	1201.0
RPL10L	-17282.0	-14934.0
RPL11	-8184.0	4520.0
RPL12	-4128.0	2724.0
RPL13	249.0	497.0
RPL13A	-4766.5	-7927.5
RPL14	-1225.0	-9732.0
RPL15	-4028.0	2643.0
RPL17	398.0	-12856.0
RPL18	-152.0	6522.0
RPL18A	-498.0	-10349.0
RPL19	-4251.0	3231.0
RPL21	-2014.0	3806.0
RPL22	-6992.0	-5217.0
RPL22L1	-13316.0	-13765.0
RPL23	2192.0	6437.0
RPL23A	49.0	-3660.0
RPL24	-8846.0	4441.0
RPL26	-353.0	5155.0
RPL26L1	-2664.0	-2912.0
RPL27	-3413.0	-1641.0
RPL27A	-628.0	1877.0
RPL28	2808.0	-2646.0
RPL29	-2215.0	1142.0
RPL3	-2551.0	5035.0
RPL30	-2037.0	-7771.0
RPL31	-11010.0	537.0
RPL32	1166.0	-7362.0
RPL34	2673.5	3911.0
RPL35	423.0	7570.0
RPL35A	3401.0	6350.0
RPL36	-2802.0	-3096.0
RPL36AL	-3982.0	3938.0
RPL37	-1931.0	-8725.0
RPL37A	-2812.0	4394.0
RPL38	-10902.0	3642.0
RPL39L	1257.0	-6117.0
RPL3L	-7041.0	-16385.0
RPL4	3510.0	124.0
RPL41	3270.0	5146.0
RPL5	-366.0	-12499.0
RPL6	-5398.0	910.0
RPL7	-1160.0	5094.0
RPL7A	-1890.0	1508.5
RPL8	-1214.0	-4009.0
RPL9	-181.0	-6342.0
RPLP0	-5253.0	-3921.0
RPLP1	-12660.0	-5577.0
RPLP2	-821.0	-6905.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0
UBA52	-4599.0	1289.0
UPF1	-10337.0	2776.0

---

---

Digestion

Digestion

metric	value
setSize	18
pMANOVA	0.00338
p.adjustMANOVA	0.0203
s.dist	0.498
s.bl	-0.241
s.gu	-0.435
p.bl	0.0767
p.gu	0.00139

Top 20 genes

Gene	bl	gu
LIPF	-20564	-17104
PNLIPRP3	-20687	-16062
AMY2A	-19810	-14644
CHIA	-20312	-13999
AMY2B	-18663	-14390
PNLIP	-20948	-12427
ALPI	-9659	-16814
CEL	-14510	-10772
PNLIPRP2	-14977	-10332
LCT	-7408	-12222
GUCA2B	-9054	-9808
TREH	-3390	-15321
PNLIPRP1	-1665	-15481
MGAM	-13079	-1358
CLPS	-272	-8469
CHIT1	-1801	-533

Click HERE to show all gene set members

All member genes

	bl	gu
ALPI	-9659	-16814
AMY2A	-19810	-14644
AMY2B	-18663	-14390
CEL	-14510	-10772
CHIA	-20312	-13999
CHIT1	-1801	-533
CLPS	-272	-8469
GUCA2A	-15132	4867
GUCA2B	-9054	-9808
GUCY2C	2145	-8055
LCT	-7408	-12222
LIPF	-20564	-17104
MGAM	-13079	-1358
PNLIP	-20948	-12427
PNLIPRP1	-1665	-15481
PNLIPRP2	-14977	-10332
PNLIPRP3	-20687	-16062
TREH	-3390	-15321

---

---

cGMP effects

cGMP effects

metric	value
setSize	15
pMANOVA	0.00692
p.adjustMANOVA	0.0358
s.dist	0.497
s.bl	-0.175
s.gu	-0.465
p.bl	0.241
p.gu	0.00183

Top 20 genes

Gene	bl	gu
PDE1A	-20126	-15813
KCNMB2	-19095	-16346
PDE5A	-16093	-13960
PDE10A	-16620	-13469
PDE11A	-15920	-13450
KCNMB3	-12965	-15714
KCNMB4	-13970	-14419
PRKG2	-7627	-14919
PRKG1	-6667	-10908
PDE1B	-9254	-5134
KCNMA1	-3268	-10584
PDE2A	-3316	-9660
KCNMB1	-978	-8952
PDE9A	-1697	-3127
ITPR1	-14464	-18

Click HERE to show all gene set members

All member genes

	bl	gu
ITPR1	-14464	-18
KCNMA1	-3268	-10584
KCNMB1	-978	-8952
KCNMB2	-19095	-16346
KCNMB3	-12965	-15714
KCNMB4	-13970	-14419
PDE10A	-16620	-13469
PDE11A	-15920	-13450
PDE1A	-20126	-15813
PDE1B	-9254	-5134
PDE2A	-3316	-9660
PDE5A	-16093	-13960
PDE9A	-1697	-3127
PRKG1	-6667	-10908
PRKG2	-7627	-14919

---

---

Apoptotic cleavage of cell adhesion proteins

Apoptotic cleavage of cell adhesion proteins

metric	value
setSize	11
pMANOVA	0.0262
p.adjustMANOVA	0.1
s.dist	0.493
s.bl	-0.467
s.gu	-0.16
p.bl	0.00737
p.gu	0.358

Top 20 genes

Gene	bl	gu
DSG1	-19812.5	-16026
DSG3	-21034.0	-11703
TJP2	-15915.0	-12400
CTNNB1	-17702.0	-8664
TJP1	-14612.0	-9609
OCLN	-15670.0	-7424
DSG2	-15416.0	-3491
CASP3	-9968.0	-5082
DSP	-12081.0	-3734
CDH1	-12881.0	-1437

Click HERE to show all gene set members

All member genes

	bl	gu
CASP3	-9968.0	-5082
CDH1	-12881.0	-1437
CTNNB1	-17702.0	-8664
DSG1	-19812.5	-16026
DSG2	-15416.0	-3491
DSG3	-21034.0	-11703
DSP	-12081.0	-3734
OCLN	-15670.0	-7424
PKP1	-5007.0	541
TJP1	-14612.0	-9609
TJP2	-15915.0	-12400

---

---

Autodegradation of Cdh1 by Cdh1:APC/C

Autodegradation of Cdh1 by Cdh1:APC/C

metric	value
setSize	62
pMANOVA	1.34e-08
p.adjustMANOVA	3.45e-07
s.dist	0.489
s.bl	0.321
s.gu	0.368
p.bl	1.23e-05
p.gu	5.2e-07

Top 20 genes

Gene	bl	gu
PSMC2	3803	6031
PSMD7	2498	6265
PSMA5	2585	5285
ANAPC10	2109	5652
RPS27A	2779	3982
PSME1	1078	7207
PSMD3	1361	5234
PSMD4	2353	1690
UBB	3388	1123
ANAPC1	824	3887
PSMC4	2132	1280

Click HERE to show all gene set members

All member genes

	bl	gu
ANAPC1	824.0	3887.0
ANAPC10	2109.0	5652.0
ANAPC11	-2940.0	559.0
ANAPC15	-13367.0	1632.0
ANAPC16	-2837.0	3549.0
ANAPC2	-7259.0	4672.0
ANAPC4	-6445.0	-2337.0
ANAPC5	-15161.0	-437.0
ANAPC7	-2356.0	1878.0
CDC16	-1149.0	-35.5
CDC23	2732.0	-6247.0
CDC26	-2798.0	2516.0
CDC27	-16955.0	-12615.0
FZR1	-14570.0	5723.0
PSMA1	-3412.0	3959.0
PSMA2	1412.0	-6569.0
PSMA3	-228.0	2621.0
PSMA4	-1743.0	-555.0
PSMA5	2585.0	5285.0
PSMA6	-6674.0	3459.0
PSMA7	-4079.0	6186.0
PSMB1	469.0	-7922.0
PSMB10	-11837.0	-4265.0
PSMB2	-6922.0	3968.0
PSMB3	-3000.0	-1468.0
PSMB4	-371.0	-15631.0
PSMB5	-4730.0	-8797.0
PSMB6	-8722.0	-5248.0
PSMB7	-9915.0	5802.0
PSMB8	-716.0	-5924.0
PSMB9	1092.0	-3360.0
PSMC1	-3206.0	-10570.0
PSMC2	3803.0	6031.0
PSMC3	-12761.0	4254.0
PSMC4	2132.0	1280.0
PSMC5	-1961.0	1861.0
PSMC6	-8378.0	6462.0
PSMD1	-19184.0	-10852.0
PSMD11	-4049.0	-3275.0
PSMD12	24.0	-7256.0
PSMD13	-2337.0	3893.0
PSMD14	-18126.0	-4800.0
PSMD2	-6559.0	2157.0
PSMD3	1361.0	5234.0
PSMD4	2353.0	1690.0
PSMD5	-65.5	2411.0
PSMD6	-17603.0	-12820.0
PSMD7	2498.0	6265.0
PSMD8	-9033.0	721.0
PSMD9	-12004.0	-5850.0
PSME1	1078.0	7207.0
PSME2	-464.0	2740.0
PSME3	1492.0	-773.0
PSMF1	-5127.0	-498.0
RPS27A	2779.0	3982.0
UBA52	-4599.0	1289.0
UBB	3388.0	1123.0
UBC	188.0	-1339.0
UBE2C	-1179.0	-590.0
UBE2D1	-15009.0	2477.0
UBE2E1	-13606.0	-5318.0
UBE2S	-4287.0	-1901.0

---

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

metric	value
setSize	94
pMANOVA	3.8e-13
p.adjustMANOVA	1.84e-11
s.dist	0.488
s.bl	0.428
s.gu	0.234
p.bl	6.78e-13
p.gu	8.8e-05

Top 20 genes

Gene	bl	gu
RPL35A	3401.0	6350
RPL41	3270.0	5146
RPL23	2192.0	6437
RPS27A	2779.0	3982
RPL34	2673.5	3911
RPS19	2386.0	3424
RPS12	3712.0	1981
RPSA	1158.5	3800
RPS17	1109.0	2983
RPL35	423.0	7570
RPS18	1884.0	929
RPS27	108.0	6831
RPL4	3510.0	124
EIF3D	56.0	2540
RPL13	249.0	497

Click HERE to show all gene set members

All member genes

	bl	gu
EIF3A	-12510.0	-8479.0
EIF3B	-3365.0	493.0
EIF3D	56.0	2540.0
EIF3E	-17188.0	1232.0
EIF3F	-11740.0	-12449.0
EIF3G	715.0	-1643.0
EIF3H	-14063.0	-13479.0
EIF3I	-6309.0	-10546.0
EIF3J	-4722.0	-6336.0
EIF3K	2965.0	-5480.0
EIF3L	-11637.0	-8130.0
EIF3M	-1730.0	-1102.0
FAU	925.0	-3977.5
RPL10A	-2725.0	1201.0
RPL10L	-17282.0	-14934.0
RPL11	-8184.0	4520.0
RPL12	-4128.0	2724.0
RPL13	249.0	497.0
RPL13A	-4766.5	-7927.5
RPL14	-1225.0	-9732.0
RPL15	-4028.0	2643.0
RPL17	398.0	-12856.0
RPL18	-152.0	6522.0
RPL18A	-498.0	-10349.0
RPL19	-4251.0	3231.0
RPL21	-2014.0	3806.0
RPL22	-6992.0	-5217.0
RPL22L1	-13316.0	-13765.0
RPL23	2192.0	6437.0
RPL23A	49.0	-3660.0
RPL24	-8846.0	4441.0
RPL26	-353.0	5155.0
RPL26L1	-2664.0	-2912.0
RPL27	-3413.0	-1641.0
RPL27A	-628.0	1877.0
RPL28	2808.0	-2646.0
RPL29	-2215.0	1142.0
RPL3	-2551.0	5035.0
RPL30	-2037.0	-7771.0
RPL31	-11010.0	537.0
RPL32	1166.0	-7362.0
RPL34	2673.5	3911.0
RPL35	423.0	7570.0
RPL35A	3401.0	6350.0
RPL36	-2802.0	-3096.0
RPL36AL	-3982.0	3938.0
RPL37	-1931.0	-8725.0
RPL37A	-2812.0	4394.0
RPL38	-10902.0	3642.0
RPL39L	1257.0	-6117.0
RPL3L	-7041.0	-16385.0
RPL4	3510.0	124.0
RPL41	3270.0	5146.0
RPL5	-366.0	-12499.0
RPL6	-5398.0	910.0
RPL7	-1160.0	5094.0
RPL7A	-1890.0	1508.5
RPL8	-1214.0	-4009.0
RPL9	-181.0	-6342.0
RPLP0	-5253.0	-3921.0
RPLP1	-12660.0	-5577.0
RPLP2	-821.0	-6905.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0
UBA52	-4599.0	1289.0

---

---

Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization

metric	value
setSize	14
pMANOVA	0.0172
p.adjustMANOVA	0.0726
s.dist	0.485
s.bl	0.294
s.gu	0.385
p.bl	0.0569
p.gu	0.0126

Top 20 genes

Gene	bl	gu
BLZF1	2719	5382
MAPK3	571	1283
USO1	26	6533

Click HERE to show all gene set members

All member genes

	bl	gu
BLZF1	2719	5382.0
CCNB1	-14474	4209.0
CCNB2	-15031	670.0
CDK1	-1283	-2793.5
GOLGA2	-2325	7394.0
GORASP1	-4368	-886.0
GORASP2	-7250	-10596.0
MAPK1	-7756	-9326.0
MAPK3	571	1283.0
PLK1	-4741	-91.0
RAB1A	-4554	-8038.0
RAB1B	-4352	6424.0
RAB2A	-4119	-2605.0
USO1	26	6533.0

---

---

Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors

metric	value
setSize	356
pMANOVA	1.04e-44
p.adjustMANOVA	1.61e-41
s.dist	0.483
s.bl	-0.301
s.gu	-0.377
p.bl	1.26e-22
p.gu	1.49e-34

Top 20 genes

Gene	bl	gu
OR8H3	-21295	-17966
OR2L2	-21412	-17740
OR2J2	-21111	-17767
OR4D5	-21207	-17593
OR2M7	-21139	-17540
OR13C2	-21040	-17548
OR6T1	-20889	-17509
OR52E4	-21016	-17389
OR4N4	-20817	-17452
OR4K13	-21317	-17030
OR10A6	-20802	-17388
OR52E8	-20603	-17455
OR4P4	-20996	-17114
OR5I1	-21033	-17033
OR5F1	-20414	-17467
OR13F1	-20176	-17643
OR14A16	-20867	-17057
OR2W3	-20737	-16990
OR5M1	-20550	-17119
OR2A2	-19977	-17556

Click HERE to show all gene set members

All member genes

	bl	gu
EBF1	-4607.0	-7614.0
LDB1	-11257.0	-2638.0
LHX2	-8474.0	1928.0
OR10A2	-20763.0	-15507.0
OR10A3	-355.0	-15310.0
OR10A4	-18812.0	-17278.0
OR10A5	-20903.0	-15667.0
OR10A6	-20802.0	-17388.0
OR10A7	-21274.0	-13436.0
OR10AD1	-1622.0	-13356.0
OR10AG1	3830.0	-13668.0
OR10C1	-17424.0	-14677.0
OR10G2	-10006.0	-15965.0
OR10G3	-8565.0	3345.0
OR10G4	-16716.0	-13162.0
OR10G7	-18505.0	-11695.0
OR10G8	-19541.0	-13250.0
OR10G9	-21308.0	-12269.0
OR10H1	-9570.0	-15466.0
OR10H2	2053.0	-7383.0
OR10H3	-6678.0	143.0
OR10H4	-20437.0	-16979.0
OR10H5	3826.0	6069.0
OR10J1	-20267.0	-14811.0
OR10J3	-3352.0	-3751.0
OR10J5	-3484.0	-6964.0
OR10K1	-19645.0	4573.0
OR10K2	-16929.0	-15838.0
OR10P1	351.0	-15934.0
OR10Q1	-20829.0	-5118.0
OR10R2	-20796.0	7729.0
OR10S1	1816.0	-3647.0
OR10T2	2803.0	4190.0
OR10V1	-9125.0	-16782.0
OR10W1	-21210.0	-16004.0
OR10X1	-18965.0	-14049.0
OR10Z1	-12477.0	-9585.0
OR11A1	-3059.0	-11489.0
OR11G2	-17321.0	-7259.0
OR11H2	-21362.0	-10990.0
OR11H4	-813.0	7109.0
OR11H6	1684.0	-17199.0
OR11L1	-20701.0	-4094.0
OR12D2	-20376.0	-16547.0
OR12D3	-6424.0	-11374.0
OR13A1	-16139.0	-15683.0
OR13C2	-21040.0	-17548.0
OR13C3	-20098.0	-11234.0
OR13C4	2512.0	-17377.0
OR13C8	-20350.0	-17190.0
OR13C9	-20669.0	-11343.0
OR13D1	-20870.0	-1605.0
OR13F1	-20176.0	-17643.0
OR13G1	-21241.0	-16236.0
OR13J1	-5366.0	-14519.0
OR14A16	-20867.0	-17057.0
OR14C36	4085.0	-17517.0
OR14I1	-16199.0	-15044.0
OR14J1	-11682.0	-10594.0
OR1A1	-13388.0	-15482.0
OR1A2	-16873.0	-16173.0
OR1B1	3319.0	-13807.0
OR1C1	-19789.0	-15645.0
OR1D2	-19602.0	-1492.0
OR1E1	3772.0	-2806.0
OR1E2	3960.0	-8351.0
OR1F1	148.0	-14911.0
OR1G1	2922.0	-11715.0
OR1I1	3740.0	1336.0
OR1J1	-18408.0	-9276.0
OR1J2	-16330.0	-13462.0
OR1J4	4116.0	6550.0
OR1K1	-1672.0	-15198.0
OR1L1	-4957.0	426.0
OR1L3	2967.0	3087.0
OR1L4	-21286.0	3871.0
OR1L6	-20261.0	7427.0
OR1L8	-19004.0	-12813.0
OR1M1	-6683.0	5268.0
OR1N1	1070.0	-16650.0
OR1N2	-20498.0	-5719.0
OR1Q1	4233.0	-13760.0
OR1S1	-19821.0	-14546.0
OR1S2	-7802.0	-16740.0
OR2A12	-19823.0	-11640.0
OR2A14	-19848.0	-17012.0
OR2A2	-19977.0	-17556.0
OR2A25	-21085.0	-11815.0
OR2A5	-18411.0	-15200.0
OR2AE1	-10611.0	3339.0
OR2AG1	3699.0	-15888.0
OR2AG2	-16828.0	-16415.0
OR2AK2	-21134.0	601.0
OR2AP1	561.0	-432.0
OR2AT4	-19115.0	-15960.0
OR2B11	-2663.0	-3263.0
OR2B2	-18109.0	-11104.0
OR2B3	-19155.0	-16552.0
OR2B6	-14116.0	-10859.0
OR2C1	76.0	5286.0
OR2C3	-16344.0	2812.0
OR2D2	3770.0	-16104.0
OR2D3	-20619.0	-1568.0
OR2F1	-17126.0	-5207.0
OR2F2	362.0	-17316.0
OR2G2	-15328.0	-17822.0
OR2G3	-20934.0	-13010.0
OR2G6	-20344.0	-14994.0
OR2H1	-15882.0	-10344.0
OR2H2	2088.0	-9186.0
OR2J2	-21111.0	-17767.0
OR2K2	-19742.0	-13930.0
OR2L13	-20152.0	-15080.0
OR2L2	-21412.0	-17740.0
OR2L3	-20371.0	-16106.0
OR2L5	-21135.0	-10376.0
OR2L8	-20540.0	-12310.0
OR2M2	-9817.0	-14536.0
OR2M3	-2930.0	-14126.0
OR2M4	-20538.0	-15869.0
OR2M5	-16892.0	-2830.0
OR2M7	-21139.0	-17540.0
OR2S2	3516.0	-6983.0
OR2T1	-16639.0	-11877.0
OR2T10	-10146.0	-5833.0
OR2T11	3028.0	-14696.0
OR2T12	-20997.0	-4899.0
OR2T27	3968.0	-11369.0
OR2T3	3644.0	-9521.0
OR2T33	3747.0	-14061.0
OR2T34	4011.0	-14045.0
OR2T4	3374.0	-3300.0
OR2T6	-6588.0	-13835.0
OR2T8	-20662.0	-16637.0
OR2V1	356.0	-9433.0
OR2V2	-5955.0	6323.0
OR2W1	-21300.0	-15900.5
OR2W3	-20737.0	-16990.0
OR2W5	-2257.0	-612.0
OR2Y1	-20620.0	-10502.0
OR2Z1	-20044.0	-10749.0
OR3A1	-4525.0	2860.0
OR3A2	-18052.0	6549.0
OR3A3	967.0	5247.0
OR4A15	-17516.0	-5199.0
OR4A16	2343.0	-10009.0
OR4A47	-1767.0	-17521.0
OR4A5	3532.0	5463.0
OR4B1	-19101.0	-16291.0
OR4C12	3397.0	-5228.0
OR4C13	3571.0	7555.0
OR4C15	-12371.0	-14347.0
OR4C16	2897.0	-9707.0
OR4C3	3936.0	1969.0
OR4C45	-20099.0	-14133.0
OR4C46	4257.0	7679.0
OR4C6	4158.0	5887.0
OR4D1	-20008.0	-14019.0
OR4D10	-20560.0	3873.0
OR4D11	-2652.0	-15821.0
OR4D2	-19039.0	-15047.0
OR4D5	-21207.0	-17593.0
OR4D6	-7285.0	-17584.0
OR4D9	-20396.0	5408.0
OR4E2	-1159.0	-17725.0
OR4F15	-20965.0	-12338.0
OR4F6	887.0	-1699.0
OR4K1	3994.0	-16555.0
OR4K13	-21317.0	-17030.0
OR4K14	-21309.0	-3625.0
OR4K15	-9912.0	6349.0
OR4K17	-14503.0	-15400.0
OR4K2	-19628.0	-12433.0
OR4K5	-21246.0	44.0
OR4L1	-20478.0	-16227.0
OR4M1	-21336.0	-15705.0
OR4M2	-1223.0	-15547.0
OR4N2	-1906.0	-370.0
OR4N4	-20817.0	-17452.0
OR4N5	3050.0	-11226.0
OR4P4	-20996.0	-17114.0
OR4Q3	4035.0	4667.0
OR4S1	-16916.0	-17019.0
OR4S2	-9074.0	-11520.0
OR4X1	4244.0	6389.0
OR4X2	4229.0	-410.0
OR51A2	-21180.0	-6267.0
OR51A4	-20495.0	-6757.0
OR51A7	1675.0	6961.0
OR51B2	-19548.0	-13037.0
OR51B4	-18902.0	-16465.0
OR51B5	-12215.0	-12925.0
OR51B6	-11456.0	-15128.0
OR51D1	-361.0	-17586.0
OR51E1	-2769.0	-16297.0
OR51E2	-20766.0	-12881.0
OR51F1	786.0	-4678.0
OR51F2	-19156.0	-15289.0
OR51G1	-10614.0	-14625.0
OR51G2	-86.0	-17512.0
OR51I1	-6848.0	-1712.0
OR51I2	-17444.0	-7944.0
OR51L1	-20523.0	-10390.0
OR51M1	-21037.0	-12015.0
OR51Q1	2256.0	-13486.0
OR51S1	-16017.0	-14886.0
OR51T1	-4238.0	-12802.0
OR51V1	-20693.0	-16891.0
OR52A1	-14681.0	-3691.0
OR52A5	-19667.0	4683.0
OR52B2	-15790.0	-15269.0
OR52B6	-10135.0	-8030.0
OR52D1	-19847.0	-15149.0
OR52E2	-14459.0	4383.0
OR52E4	-21016.0	-17389.0
OR52E6	35.0	-16713.0
OR52E8	-20603.0	-17455.0
OR52H1	-13588.0	-14008.0
OR52I1	-17627.0	-13728.0
OR52I2	-20425.0	-16755.0
OR52J3	-19755.0	-17468.0
OR52K1	-19186.0	-12261.0
OR52K2	-18425.0	4346.0
OR52L1	1362.0	-10064.0
OR52M1	520.0	-14102.0
OR52N1	-21363.0	-9945.0
OR52N2	-13520.0	2974.0
OR52N5	-19171.0	-14296.0
OR52R1	-16823.0	-12552.0
OR52W1	-14364.0	-15639.0
OR56A1	-17671.0	-17041.0
OR56A3	-17669.0	6778.0
OR56A4	-9866.0	-11362.0
OR56A5	3525.0	-14146.0
OR56B1	-19856.0	-12537.0
OR56B4	3035.0	-14490.0
OR5A1	3335.0	-14356.0
OR5A2	-8467.0	-15500.0
OR5AC2	-20424.0	-17102.0
OR5AK2	-21391.0	-15108.0
OR5AN1	-20881.0	-6671.0
OR5AP2	-20009.0	803.0
OR5AR1	-20764.0	-14184.0
OR5AS1	-19958.0	1460.0
OR5AU1	3505.0	-3375.0
OR5B12	-19924.0	-17120.0
OR5B17	3686.0	-17888.0
OR5B2	-20568.0	6216.0
OR5B21	-14065.0	-12758.0
OR5B3	-14598.0	-17487.0
OR5C1	-13387.0	-12676.0
OR5D13	-7839.0	-17621.0
OR5D14	4270.0	-17743.0
OR5D16	-15849.0	-17646.0
OR5D18	-20627.0	2444.0
OR5F1	-20414.0	-17467.0
OR5H1	-12305.0	-17723.0
OR5H15	-13963.0	-15973.0
OR5H2	-15583.0	-15643.0
OR5H6	3882.0	-6637.0
OR5I1	-21033.0	-17033.0
OR5J2	-20101.0	-16328.0
OR5K1	-20839.0	-12822.0
OR5K2	-21268.0	-16441.0
OR5K3	-20139.0	-7667.0
OR5K4	-19331.0	-16844.0
OR5L1	-19242.0	-16241.0
OR5L2	-19366.0	-17441.0
OR5M1	-20550.0	-17119.0
OR5M10	-15700.0	-13199.0
OR5M11	-20634.0	-14129.0
OR5M3	-20165.0	7624.0
OR5M8	-16159.0	-8017.0
OR5M9	-20418.0	-15416.0
OR5P2	-14546.0	-10528.0
OR5P3	-18273.0	-17005.0
OR5R1	-21379.0	1826.0
OR5T1	-16253.0	-11675.0
OR5T2	-16781.0	-13179.0
OR5T3	-21388.0	-12293.0
OR5V1	-20496.0	-6517.0
OR5W2	-18808.0	-16870.0
OR6A2	-18405.0	-12495.0
OR6B1	-19898.0	-16076.0
OR6B2	-1570.0	2625.0
OR6B3	2212.0	-11539.0
OR6C1	-21008.0	-14079.0
OR6C2	-20663.0	-7392.0
OR6C3	173.0	-12201.0
OR6C4	-20660.0	2222.0
OR6C6	-21175.0	7465.0
OR6C65	-19573.0	-9634.0
OR6C68	-20524.0	-16352.0
OR6C70	-20353.0	-16228.0
OR6C74	-13304.0	-16687.0
OR6C75	-21050.0	-15649.0
OR6C76	-21002.0	-14597.0
OR6F1	-21277.0	-13087.0
OR6K2	-18223.0	-10981.0
OR6K3	2122.0	-14065.0
OR6K6	-14920.0	-16846.0
OR6M1	-20061.0	-16481.0
OR6N1	-3986.0	-17052.0
OR6N2	-10439.0	459.0
OR6P1	-12225.0	-6467.0
OR6Q1	3286.0	-17905.0
OR6S1	-15771.0	2662.0
OR6T1	-20889.0	-17509.0
OR6V1	2458.0	3606.0
OR6X1	-19978.0	-12087.0
OR6Y1	-16624.0	-15641.0
OR7A10	-16750.0	-17271.0
OR7A17	-19386.0	4435.0
OR7A5	-19361.0	-12513.0
OR7C1	-17807.0	-6752.0
OR7C2	-17874.0	-12138.0
OR7D2	-20377.0	-11053.0
OR7D4	-16252.0	568.0
OR7E24	-12614.0	-17939.0
OR7G1	-15408.0	3204.0
OR7G2	-17575.0	-17854.0
OR7G3	1722.0	5036.0
OR8A1	-20654.0	-15734.0
OR8B12	-20800.0	504.0
OR8B2	-20249.0	-17168.0
OR8B4	4112.0	-16267.0
OR8B8	-2684.0	-12175.0
OR8D1	-19381.0	-16682.0
OR8D2	-20295.0	-14492.0
OR8D4	-5207.0	-8839.0
OR8G1	-21287.0	-9239.0
OR8G2	-18458.0	-17348.0
OR8G5	-21183.0	-574.0
OR8H1	-19984.0	-4583.0
OR8H2	-3353.0	-15098.0
OR8H3	-21295.0	-17966.0
OR8I2	-18708.0	-8253.0
OR8J3	-19033.0	-8395.0
OR8K1	-21019.0	-16569.0
OR8K3	-20645.0	-14600.0
OR8K5	-20499.0	-7930.0
OR8S1	-3383.0	-6322.0
OR8U1	-21214.0	-8866.0
OR8U8	-18259.0	-8274.0
OR9A2	-10349.0	-2819.0
OR9A4	-16754.0	-16152.0
OR9G1	-11101.5	2872.5
OR9G4	-13372.0	-16761.0
OR9G9	-11101.5	2872.5
OR9I1	-15646.0	6168.0
OR9K2	3444.0	-15811.0
OR9Q1	183.0	-4560.0
OR9Q2	-10478.0	1344.0
REEP1	-397.0	-3685.0
RTP1	-3826.0	-1237.0
RTP2	-3984.5	-17516.0

---

---

Sensory perception of taste

Sensory perception of taste

metric	value
setSize	47
pMANOVA	1.51e-06
p.adjustMANOVA	2.2e-05
s.dist	0.483
s.bl	-0.356
s.gu	-0.326
p.bl	2.34e-05
p.gu	0.000112

Top 20 genes

Gene	bl	gu
TAS2R1	-20622	-17254
TAS2R30	-20349	-17048
GNAT3	-20925	-16539
TAS2R43	-19506	-17735
TAS2R20	-20843	-16146
TAS2R39	-20436	-16166
TAS2R8	-20815	-15843
TAS2R14	-20401	-15992
TAS2R10	-20808	-15531
TAS2R3	-20588	-15670
TAS2R50	-20655	-15542
TAS2R7	-20985	-14249
TAS2R4	-15734	-17801
TAS2R41	-17057	-15997
TAS2R16	-19868	-13499
SCN9A	-18868	-13444
GRM1	-15782	-11542
SCNN1A	-14674	-12204
KCNJ2	-11645	-11590
TAS2R38	-13472	-9265

Click HERE to show all gene set members

All member genes

	bl	gu
CALHM1	-12188	-2677
CALHM3	-4746	-13693
GNAT3	-20925	-16539
GNB1	-14571	-6653
GNB3	-11537	545
GNG13	-11606	967
GRM1	-15782	-11542
GRM4	-6548	-5884
ITPR3	-9888	-11907
KCNJ2	-11645	-11590
OTOP1	1246	-17535
PLCB2	-10727	-6613
SCN1B	-12569	-5295
SCN2A	-8505	-11243
SCN2B	-8008	-502
SCN3A	-6568	-9542
SCN4B	-7359	-1722
SCN9A	-18868	-13444
SCNN1A	-14674	-12204
SCNN1B	-344	-4562
SCNN1D	-7541	-11728
SCNN1G	2133	3347
TAS1R1	-6476	-13299
TAS1R2	-3439	-222
TAS1R3	-8432	4321
TAS2R1	-20622	-17254
TAS2R10	-20808	-15531
TAS2R13	-16276	4054
TAS2R14	-20401	-15992
TAS2R16	-19868	-13499
TAS2R20	-20843	-16146
TAS2R3	-20588	-15670
TAS2R30	-20349	-17048
TAS2R31	-19199	-3717
TAS2R38	-13472	-9265
TAS2R39	-20436	-16166
TAS2R4	-15734	-17801
TAS2R40	-16822	1556
TAS2R41	-17057	-15997
TAS2R43	-19506	-17735
TAS2R46	-19962	1261
TAS2R5	-13596	-8572
TAS2R50	-20655	-15542
TAS2R7	-20985	-14249
TAS2R8	-20815	-15843
TRPM4	-6659	-11180
TRPM5	-3048	-7798

---

---

Competing endogenous RNAs (ceRNAs) regulate PTEN translation

Competing endogenous RNAs (ceRNAs) regulate PTEN translation

metric	value
setSize	16
pMANOVA	0.00123
p.adjustMANOVA	0.00868
s.dist	0.482
s.bl	-0.456
s.gu	0.157
p.bl	0.00158
p.gu	0.276

Top 20 genes

Gene	bl	gu
MIR19A	-20776.5	7452.0
MIR20A	-16334.0	7304.5
MIR17	-10949.0	6611.0
MIR106B	-16526.5	1207.0
MOV10	-4460.0	4163.0

Click HERE to show all gene set members

All member genes

	bl	gu
AGO1	-19706.0	-17640.0
AGO2	-5507.0	-1003.0
AGO3	-14355.0	-6753.0
AGO4	-19346.0	-14073.0
CNOT6L	-14309.0	-5432.0
MIR106B	-16526.5	1207.0
MIR17	-10949.0	6611.0
MIR19A	-20776.5	7452.0
MIR19B1	-20004.0	-1283.0
MIR20A	-16334.0	7304.5
MOV10	-4460.0	4163.0
PTENP1	-13616.0	-5412.0
TNRC6A	-17740.0	-10466.0
TNRC6B	-5736.0	-6748.0
TNRC6C	-16064.0	-6749.0
VAPA	-15272.0	-839.0

---

---

TICAM1, RIP1-mediated IKK complex recruitment

TICAM1, RIP1-mediated IKK complex recruitment

metric	value
setSize	18
pMANOVA	0.00599
p.adjustMANOVA	0.0327
s.dist	0.482
s.bl	0.335
s.gu	0.347
p.bl	0.0138
p.gu	0.0109

Top 20 genes

Gene	bl	gu
RPS27A	2779	3982
UBB	3388	1123
TLR3	3813	450
TICAM1	318	4885
BIRC3	2409	595

Click HERE to show all gene set members

All member genes

	bl	gu
BIRC2	-131.0	-4287
BIRC3	2409.0	595
CHUK	-10721.0	-6697
IKBKB	-15244.0	-13212
RIPK1	-15294.0	-3624
RIPK3	-7192.0	6416
RPS27A	2779.0	3982
TICAM1	318.0	4885
TLR3	3813.0	450
TRAF6	-14050.0	774
UBA52	-4599.0	1289
UBB	3388.0	1123
UBC	188.0	-1339
UBE2D1	-15009.0	2477
UBE2D2	393.0	-3347
UBE2D3	-163.5	2184
UBE2N	-6105.0	-8198
UBE2V1	-1331.0	4428

---

---

Mitophagy

Mitophagy

metric	value
setSize	27
pMANOVA	0.000487
p.adjustMANOVA	0.00384
s.dist	0.48
s.bl	0.312
s.gu	0.364
p.bl	0.00495
p.gu	0.00105

Top 20 genes

Gene	bl	gu
TOMM40	2415	6290
RPS27A	2779	3982
MFN1	2589	2907
UBB	3388	1123

Click HERE to show all gene set members

All member genes

	bl	gu
ATG12	-8297	-9286
ATG5	-11153	-1036
CSNK2A1	-2316	2242
CSNK2A2	-10434	-8385
CSNK2B	-3093	-6766
MAP1LC3A	-9396	3014
MAP1LC3B	-9320	5152
MFN1	2589	2907
MFN2	-2382	3794
MTERF3	2822	-3331
PARK2	-6751	-10836
PGAM5	-6354	5293
PINK1	-6017	5689
RPS27A	2779	3982
SQSTM1	-8373	3979
SRC	-11667	1857
TOMM20	-3644	2371
TOMM22	-1905	-5663
TOMM40	2415	6290
TOMM5	-11708	-5133
TOMM6	2452	-1322
TOMM7	-3185	-2887
UBA52	-4599	1289
UBB	3388	1123
UBC	188	-1339
ULK1	-2924	-1671
VDAC1	-15839	-3429

---

---

Activation of the TFAP2 (AP-2) family of transcription factors

Activation of the TFAP2 (AP-2) family of transcription factors

metric	value
setSize	11
pMANOVA	0.0453
p.adjustMANOVA	0.15
s.dist	0.479
s.bl	0.351
s.gu	0.326
p.bl	0.0437
p.gu	0.0608

Top 20 genes

Gene	bl	gu
CITED2	3353	6224
TFAP2D	1113	648

Click HERE to show all gene set members

All member genes

	bl	gu
CITED2	3353	6224
CITED4	-11655	5852
CREBBP	-15071	-6721
EP300	-2523	-721
TFAP2A	-1766	3002
TFAP2B	-1444	5310
TFAP2C	-2977	432
TFAP2D	1113	648
TFAP2E	-2597	-629
WWOX	-14115	-11194
YEATS4	3179	-12437

---

---

Senescence-Associated Secretory Phenotype (SASP)

Senescence-Associated Secretory Phenotype (SASP)

metric	value
setSize	53
pMANOVA	2.63e-07
p.adjustMANOVA	4.72e-06
s.dist	0.478
s.bl	0.265
s.gu	0.398
p.bl	0.000829
p.gu	5.31e-07

Top 20 genes

Gene	bl	gu
CXCL8	4091	4571
ANAPC10	2109	5652
RPS27A	2779	3982
CDK4	2873	2806
IL8	1506	5149
UBB	3388	1123
ANAPC1	824	3887
CDKN2C	973	2973
MAPK3	571	1283

Click HERE to show all gene set members

All member genes

	bl	gu
ANAPC1	824	3887.0
ANAPC10	2109	5652.0
ANAPC11	-2940	559.0
ANAPC15	-13367	1632.0
ANAPC16	-2837	3549.0
ANAPC2	-7259	4672.0
ANAPC4	-6445	-2337.0
ANAPC5	-15161	-437.0
ANAPC7	-2356	1878.0
CCNA1	-10926	-1832.0
CCNA2	-118	-26.0
CDC16	-1149	-35.5
CDC23	2732	-6247.0
CDC26	-2798	2516.0
CDC27	-16955	-12615.0
CDK2	-7142	-2291.0
CDK4	2873	2806.0
CDK6	-11928	-7135.0
CDKN1A	-4543	4884.0
CDKN1B	-1471	3198.0
CDKN2A	-2236	473.0
CDKN2B	-2016	6691.0
CDKN2C	973	2973.0
CDKN2D	-6909	1623.0
CEBPB	-8561	4504.0
CXCL8	4091	4571.0
EHMT1	-12184	376.0
EHMT2	-9236	-4062.0
FOS	-2827	2330.0
FZR1	-14570	5723.0
H2AFX	-9694	1749.0
IGFBP7	-5807	-3528.0
IL1A	-2156	-10487.0
IL6	-7806	-330.0
IL8	1506	5149.0
JUN	-4070	2093.0
MAPK1	-7756	-9326.0
MAPK3	571	1283.0
MAPK7	-7081	-4652.0
NFKB1	-322	-7808.0
RELA	-7051	4282.0
RPS27A	2779	3982.0
RPS6KA1	-14060	5752.0
RPS6KA2	-9046	-7783.0
STAT3	-2724	-6236.0
UBA52	-4599	1289.0
UBB	3388	1123.0
UBC	188	-1339.0
UBE2C	-1179	-590.0
UBE2D1	-15009	2477.0
UBE2E1	-13606	-5318.0
UBE2S	-4287	-1901.0
VENTX	-12979	1674.0

---

---

APC/C:Cdc20 mediated degradation of Cyclin B

APC/C:Cdc20 mediated degradation of Cyclin B

metric	value
setSize	24
pMANOVA	0.00114
p.adjustMANOVA	0.00825
s.dist	0.478
s.bl	0.286
s.gu	0.383
p.bl	0.0154
p.gu	0.00117

Top 20 genes

Gene	bl	gu
ANAPC10	2109	5652
RPS27A	2779	3982
UBB	3388	1123
ANAPC1	824	3887

Click HERE to show all gene set members

All member genes

	bl	gu
ANAPC1	824	3887.0
ANAPC10	2109	5652.0
ANAPC11	-2940	559.0
ANAPC15	-13367	1632.0
ANAPC16	-2837	3549.0
ANAPC2	-7259	4672.0
ANAPC4	-6445	-2337.0
ANAPC5	-15161	-437.0
ANAPC7	-2356	1878.0
CCNB1	-14474	4209.0
CDC16	-1149	-35.5
CDC20	-3637	-8857.0
CDC23	2732	-6247.0
CDC26	-2798	2516.0
CDC27	-16955	-12615.0
CDK1	-1283	-2793.5
RPS27A	2779	3982.0
UBA52	-4599	1289.0
UBB	3388	1123.0
UBC	188	-1339.0
UBE2C	-1179	-590.0
UBE2D1	-15009	2477.0
UBE2E1	-13606	-5318.0
UBE2S	-4287	-1901.0

---

---

Olfactory Signaling Pathway

Olfactory Signaling Pathway

metric	value
setSize	363
pMANOVA	3.44e-44
p.adjustMANOVA	1.77e-41
s.dist	0.475
s.bl	-0.293
s.gu	-0.374
p.bl	7.56e-22
p.gu	1.25e-34

Top 20 genes

Gene	bl	gu
OR8H3	-21295	-17966
OR2L2	-21412	-17740
OR2J2	-21111	-17767
OR4D5	-21207	-17593
OR2M7	-21139	-17540
OR13C2	-21040	-17548
OR6T1	-20889	-17509
OR52E4	-21016	-17389
OR4N4	-20817	-17452
OR4K13	-21317	-17030
OR10A6	-20802	-17388
OR52E8	-20603	-17455
OR4P4	-20996	-17114
OR5I1	-21033	-17033
OR5F1	-20414	-17467
OR13F1	-20176	-17643
OR14A16	-20867	-17057
OR2W3	-20737	-16990
OR5M1	-20550	-17119
OR2A2	-19977	-17556

Click HERE to show all gene set members

All member genes

	bl	gu
ADCY3	-5064.0	-8919.0
ANO2	-4337.0	-13706.0
CNGA4	-999.0	-17264.0
CNGB1	-1816.0	-10056.0
EBF1	-4607.0	-7614.0
GNAL	-8995.0	1359.0
GNB1	-14571.0	-6653.0
GNG13	-11606.0	967.0
LDB1	-11257.0	-2638.0
LHX2	-8474.0	1928.0
OR10A2	-20763.0	-15507.0
OR10A3	-355.0	-15310.0
OR10A4	-18812.0	-17278.0
OR10A5	-20903.0	-15667.0
OR10A6	-20802.0	-17388.0
OR10A7	-21274.0	-13436.0
OR10AD1	-1622.0	-13356.0
OR10AG1	3830.0	-13668.0
OR10C1	-17424.0	-14677.0
OR10G2	-10006.0	-15965.0
OR10G3	-8565.0	3345.0
OR10G4	-16716.0	-13162.0
OR10G7	-18505.0	-11695.0
OR10G8	-19541.0	-13250.0
OR10G9	-21308.0	-12269.0
OR10H1	-9570.0	-15466.0
OR10H2	2053.0	-7383.0
OR10H3	-6678.0	143.0
OR10H4	-20437.0	-16979.0
OR10H5	3826.0	6069.0
OR10J1	-20267.0	-14811.0
OR10J3	-3352.0	-3751.0
OR10J5	-3484.0	-6964.0
OR10K1	-19645.0	4573.0
OR10K2	-16929.0	-15838.0
OR10P1	351.0	-15934.0
OR10Q1	-20829.0	-5118.0
OR10R2	-20796.0	7729.0
OR10S1	1816.0	-3647.0
OR10T2	2803.0	4190.0
OR10V1	-9125.0	-16782.0
OR10W1	-21210.0	-16004.0
OR10X1	-18965.0	-14049.0
OR10Z1	-12477.0	-9585.0
OR11A1	-3059.0	-11489.0
OR11G2	-17321.0	-7259.0
OR11H2	-21362.0	-10990.0
OR11H4	-813.0	7109.0
OR11H6	1684.0	-17199.0
OR11L1	-20701.0	-4094.0
OR12D2	-20376.0	-16547.0
OR12D3	-6424.0	-11374.0
OR13A1	-16139.0	-15683.0
OR13C2	-21040.0	-17548.0
OR13C3	-20098.0	-11234.0
OR13C4	2512.0	-17377.0
OR13C8	-20350.0	-17190.0
OR13C9	-20669.0	-11343.0
OR13D1	-20870.0	-1605.0
OR13F1	-20176.0	-17643.0
OR13G1	-21241.0	-16236.0
OR13J1	-5366.0	-14519.0
OR14A16	-20867.0	-17057.0
OR14C36	4085.0	-17517.0
OR14I1	-16199.0	-15044.0
OR14J1	-11682.0	-10594.0
OR1A1	-13388.0	-15482.0
OR1A2	-16873.0	-16173.0
OR1B1	3319.0	-13807.0
OR1C1	-19789.0	-15645.0
OR1D2	-19602.0	-1492.0
OR1E1	3772.0	-2806.0
OR1E2	3960.0	-8351.0
OR1F1	148.0	-14911.0
OR1G1	2922.0	-11715.0
OR1I1	3740.0	1336.0
OR1J1	-18408.0	-9276.0
OR1J2	-16330.0	-13462.0
OR1J4	4116.0	6550.0
OR1K1	-1672.0	-15198.0
OR1L1	-4957.0	426.0
OR1L3	2967.0	3087.0
OR1L4	-21286.0	3871.0
OR1L6	-20261.0	7427.0
OR1L8	-19004.0	-12813.0
OR1M1	-6683.0	5268.0
OR1N1	1070.0	-16650.0
OR1N2	-20498.0	-5719.0
OR1Q1	4233.0	-13760.0
OR1S1	-19821.0	-14546.0
OR1S2	-7802.0	-16740.0
OR2A12	-19823.0	-11640.0
OR2A14	-19848.0	-17012.0
OR2A2	-19977.0	-17556.0
OR2A25	-21085.0	-11815.0
OR2A5	-18411.0	-15200.0
OR2AE1	-10611.0	3339.0
OR2AG1	3699.0	-15888.0
OR2AG2	-16828.0	-16415.0
OR2AK2	-21134.0	601.0
OR2AP1	561.0	-432.0
OR2AT4	-19115.0	-15960.0
OR2B11	-2663.0	-3263.0
OR2B2	-18109.0	-11104.0
OR2B3	-19155.0	-16552.0
OR2B6	-14116.0	-10859.0
OR2C1	76.0	5286.0
OR2C3	-16344.0	2812.0
OR2D2	3770.0	-16104.0
OR2D3	-20619.0	-1568.0
OR2F1	-17126.0	-5207.0
OR2F2	362.0	-17316.0
OR2G2	-15328.0	-17822.0
OR2G3	-20934.0	-13010.0
OR2G6	-20344.0	-14994.0
OR2H1	-15882.0	-10344.0
OR2H2	2088.0	-9186.0
OR2J2	-21111.0	-17767.0
OR2K2	-19742.0	-13930.0
OR2L13	-20152.0	-15080.0
OR2L2	-21412.0	-17740.0
OR2L3	-20371.0	-16106.0
OR2L5	-21135.0	-10376.0
OR2L8	-20540.0	-12310.0
OR2M2	-9817.0	-14536.0
OR2M3	-2930.0	-14126.0
OR2M4	-20538.0	-15869.0
OR2M5	-16892.0	-2830.0
OR2M7	-21139.0	-17540.0
OR2S2	3516.0	-6983.0
OR2T1	-16639.0	-11877.0
OR2T10	-10146.0	-5833.0
OR2T11	3028.0	-14696.0
OR2T12	-20997.0	-4899.0
OR2T27	3968.0	-11369.0
OR2T3	3644.0	-9521.0
OR2T33	3747.0	-14061.0
OR2T34	4011.0	-14045.0
OR2T4	3374.0	-3300.0
OR2T6	-6588.0	-13835.0
OR2T8	-20662.0	-16637.0
OR2V1	356.0	-9433.0
OR2V2	-5955.0	6323.0
OR2W1	-21300.0	-15900.5
OR2W3	-20737.0	-16990.0
OR2W5	-2257.0	-612.0
OR2Y1	-20620.0	-10502.0
OR2Z1	-20044.0	-10749.0
OR3A1	-4525.0	2860.0
OR3A2	-18052.0	6549.0
OR3A3	967.0	5247.0
OR4A15	-17516.0	-5199.0
OR4A16	2343.0	-10009.0
OR4A47	-1767.0	-17521.0
OR4A5	3532.0	5463.0
OR4B1	-19101.0	-16291.0
OR4C12	3397.0	-5228.0
OR4C13	3571.0	7555.0
OR4C15	-12371.0	-14347.0
OR4C16	2897.0	-9707.0
OR4C3	3936.0	1969.0
OR4C45	-20099.0	-14133.0
OR4C46	4257.0	7679.0
OR4C6	4158.0	5887.0
OR4D1	-20008.0	-14019.0
OR4D10	-20560.0	3873.0
OR4D11	-2652.0	-15821.0
OR4D2	-19039.0	-15047.0
OR4D5	-21207.0	-17593.0
OR4D6	-7285.0	-17584.0
OR4D9	-20396.0	5408.0
OR4E2	-1159.0	-17725.0
OR4F15	-20965.0	-12338.0
OR4F6	887.0	-1699.0
OR4K1	3994.0	-16555.0
OR4K13	-21317.0	-17030.0
OR4K14	-21309.0	-3625.0
OR4K15	-9912.0	6349.0
OR4K17	-14503.0	-15400.0
OR4K2	-19628.0	-12433.0
OR4K5	-21246.0	44.0
OR4L1	-20478.0	-16227.0
OR4M1	-21336.0	-15705.0
OR4M2	-1223.0	-15547.0
OR4N2	-1906.0	-370.0
OR4N4	-20817.0	-17452.0
OR4N5	3050.0	-11226.0
OR4P4	-20996.0	-17114.0
OR4Q3	4035.0	4667.0
OR4S1	-16916.0	-17019.0
OR4S2	-9074.0	-11520.0
OR4X1	4244.0	6389.0
OR4X2	4229.0	-410.0
OR51A2	-21180.0	-6267.0
OR51A4	-20495.0	-6757.0
OR51A7	1675.0	6961.0
OR51B2	-19548.0	-13037.0
OR51B4	-18902.0	-16465.0
OR51B5	-12215.0	-12925.0
OR51B6	-11456.0	-15128.0
OR51D1	-361.0	-17586.0
OR51E1	-2769.0	-16297.0
OR51E2	-20766.0	-12881.0
OR51F1	786.0	-4678.0
OR51F2	-19156.0	-15289.0
OR51G1	-10614.0	-14625.0
OR51G2	-86.0	-17512.0
OR51I1	-6848.0	-1712.0
OR51I2	-17444.0	-7944.0
OR51L1	-20523.0	-10390.0
OR51M1	-21037.0	-12015.0
OR51Q1	2256.0	-13486.0
OR51S1	-16017.0	-14886.0
OR51T1	-4238.0	-12802.0
OR51V1	-20693.0	-16891.0
OR52A1	-14681.0	-3691.0
OR52A5	-19667.0	4683.0
OR52B2	-15790.0	-15269.0
OR52B6	-10135.0	-8030.0
OR52D1	-19847.0	-15149.0
OR52E2	-14459.0	4383.0
OR52E4	-21016.0	-17389.0
OR52E6	35.0	-16713.0
OR52E8	-20603.0	-17455.0
OR52H1	-13588.0	-14008.0
OR52I1	-17627.0	-13728.0
OR52I2	-20425.0	-16755.0
OR52J3	-19755.0	-17468.0
OR52K1	-19186.0	-12261.0
OR52K2	-18425.0	4346.0
OR52L1	1362.0	-10064.0
OR52M1	520.0	-14102.0
OR52N1	-21363.0	-9945.0
OR52N2	-13520.0	2974.0
OR52N5	-19171.0	-14296.0
OR52R1	-16823.0	-12552.0
OR52W1	-14364.0	-15639.0
OR56A1	-17671.0	-17041.0
OR56A3	-17669.0	6778.0
OR56A4	-9866.0	-11362.0
OR56A5	3525.0	-14146.0
OR56B1	-19856.0	-12537.0
OR56B4	3035.0	-14490.0
OR5A1	3335.0	-14356.0
OR5A2	-8467.0	-15500.0
OR5AC2	-20424.0	-17102.0
OR5AK2	-21391.0	-15108.0
OR5AN1	-20881.0	-6671.0
OR5AP2	-20009.0	803.0
OR5AR1	-20764.0	-14184.0
OR5AS1	-19958.0	1460.0
OR5AU1	3505.0	-3375.0
OR5B12	-19924.0	-17120.0
OR5B17	3686.0	-17888.0
OR5B2	-20568.0	6216.0
OR5B21	-14065.0	-12758.0
OR5B3	-14598.0	-17487.0
OR5C1	-13387.0	-12676.0
OR5D13	-7839.0	-17621.0
OR5D14	4270.0	-17743.0
OR5D16	-15849.0	-17646.0
OR5D18	-20627.0	2444.0
OR5F1	-20414.0	-17467.0
OR5H1	-12305.0	-17723.0
OR5H15	-13963.0	-15973.0
OR5H2	-15583.0	-15643.0
OR5H6	3882.0	-6637.0
OR5I1	-21033.0	-17033.0
OR5J2	-20101.0	-16328.0
OR5K1	-20839.0	-12822.0
OR5K2	-21268.0	-16441.0
OR5K3	-20139.0	-7667.0
OR5K4	-19331.0	-16844.0
OR5L1	-19242.0	-16241.0
OR5L2	-19366.0	-17441.0
OR5M1	-20550.0	-17119.0
OR5M10	-15700.0	-13199.0
OR5M11	-20634.0	-14129.0
OR5M3	-20165.0	7624.0
OR5M8	-16159.0	-8017.0
OR5M9	-20418.0	-15416.0
OR5P2	-14546.0	-10528.0
OR5P3	-18273.0	-17005.0
OR5R1	-21379.0	1826.0
OR5T1	-16253.0	-11675.0
OR5T2	-16781.0	-13179.0
OR5T3	-21388.0	-12293.0
OR5V1	-20496.0	-6517.0
OR5W2	-18808.0	-16870.0
OR6A2	-18405.0	-12495.0
OR6B1	-19898.0	-16076.0
OR6B2	-1570.0	2625.0
OR6B3	2212.0	-11539.0
OR6C1	-21008.0	-14079.0
OR6C2	-20663.0	-7392.0
OR6C3	173.0	-12201.0
OR6C4	-20660.0	2222.0
OR6C6	-21175.0	7465.0
OR6C65	-19573.0	-9634.0
OR6C68	-20524.0	-16352.0
OR6C70	-20353.0	-16228.0
OR6C74	-13304.0	-16687.0
OR6C75	-21050.0	-15649.0
OR6C76	-21002.0	-14597.0
OR6F1	-21277.0	-13087.0
OR6K2	-18223.0	-10981.0
OR6K3	2122.0	-14065.0
OR6K6	-14920.0	-16846.0
OR6M1	-20061.0	-16481.0
OR6N1	-3986.0	-17052.0
OR6N2	-10439.0	459.0
OR6P1	-12225.0	-6467.0
OR6Q1	3286.0	-17905.0
OR6S1	-15771.0	2662.0
OR6T1	-20889.0	-17509.0
OR6V1	2458.0	3606.0
OR6X1	-19978.0	-12087.0
OR6Y1	-16624.0	-15641.0
OR7A10	-16750.0	-17271.0
OR7A17	-19386.0	4435.0
OR7A5	-19361.0	-12513.0
OR7C1	-17807.0	-6752.0
OR7C2	-17874.0	-12138.0
OR7D2	-20377.0	-11053.0
OR7D4	-16252.0	568.0
OR7E24	-12614.0	-17939.0
OR7G1	-15408.0	3204.0
OR7G2	-17575.0	-17854.0
OR7G3	1722.0	5036.0
OR8A1	-20654.0	-15734.0
OR8B12	-20800.0	504.0
OR8B2	-20249.0	-17168.0
OR8B4	4112.0	-16267.0
OR8B8	-2684.0	-12175.0
OR8D1	-19381.0	-16682.0
OR8D2	-20295.0	-14492.0
OR8D4	-5207.0	-8839.0
OR8G1	-21287.0	-9239.0
OR8G2	-18458.0	-17348.0
OR8G5	-21183.0	-574.0
OR8H1	-19984.0	-4583.0
OR8H2	-3353.0	-15098.0
OR8H3	-21295.0	-17966.0
OR8I2	-18708.0	-8253.0
OR8J3	-19033.0	-8395.0
OR8K1	-21019.0	-16569.0
OR8K3	-20645.0	-14600.0
OR8K5	-20499.0	-7930.0
OR8S1	-3383.0	-6322.0
OR8U1	-21214.0	-8866.0
OR8U8	-18259.0	-8274.0
OR9A2	-10349.0	-2819.0
OR9A4	-16754.0	-16152.0
OR9G1	-11101.5	2872.5
OR9G4	-13372.0	-16761.0
OR9G9	-11101.5	2872.5
OR9I1	-15646.0	6168.0
OR9K2	3444.0	-15811.0
OR9Q1	183.0	-4560.0
OR9Q2	-10478.0	1344.0
REEP1	-397.0	-3685.0
RTP1	-3826.0	-1237.0
RTP2	-3984.5	-17516.0

---

---

SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery

metric	value
setSize	46
pMANOVA	2.34e-06
p.adjustMANOVA	3.12e-05
s.dist	0.474
s.bl	0.4
s.gu	0.253
p.bl	2.62e-06
p.gu	0.00295

Top 20 genes

Gene	bl	gu
GEMIN6	3410.0	3366
RPS27A	2779.0	3982
RPS19	2386.0	3424
RPS12	3712.0	1981
SNRPD3	2044.0	2913
RPSA	1158.5	3800
RPS17	1109.0	2983
RPS18	1884.0	929
RPS27	108.0	6831

Click HERE to show all gene set members

All member genes

	bl	gu
DDX20	-9359.5	3846.0
FAU	925.0	-3977.5
GEMIN2	-9777.0	314.0
GEMIN4	-5948.0	1156.5
GEMIN5	-5953.0	5518.0
GEMIN6	3410.0	3366.0
GEMIN7	-7641.0	-7237.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0
SMN1	-18140.5	-6496.5
SNRPB	-9444.0	-15598.0
SNRPD1	-1691.0	5435.0
SNRPD2	-849.0	-2166.0
SNRPD3	2044.0	2913.0
SNRPE	-11187.0	-6572.0
SNRPF	-12431.0	-10074.0
SNRPG	-6201.0	-4638.0

---

---

GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

metric	value
setSize	50
pMANOVA	1.25e-06
p.adjustMANOVA	1.86e-05
s.dist	0.471
s.bl	0.321
s.gu	0.345
p.bl	8.54e-05
p.gu	2.4e-05

Top 20 genes

Gene	bl	gu
PSMC2	3803	6031
PSMD7	2498	6265
PSMA5	2585	5285
RPS27A	2779	3982
PSME1	1078	7207
PSMD3	1361	5234
SKP1	1474	4634
PSMD4	2353	1690
UBB	3388	1123
PSMC4	2132	1280

Click HERE to show all gene set members

All member genes

	bl	gu
BTRC	-19196.0	-1991
CUL1	-15085.0	-7180
GSK3B	-11076.0	-12454
NFE2L2	-9157.0	5598
PSMA1	-3412.0	3959
PSMA2	1412.0	-6569
PSMA3	-228.0	2621
PSMA4	-1743.0	-555
PSMA5	2585.0	5285
PSMA6	-6674.0	3459
PSMA7	-4079.0	6186
PSMB1	469.0	-7922
PSMB10	-11837.0	-4265
PSMB2	-6922.0	3968
PSMB3	-3000.0	-1468
PSMB4	-371.0	-15631
PSMB5	-4730.0	-8797
PSMB6	-8722.0	-5248
PSMB7	-9915.0	5802
PSMB8	-716.0	-5924
PSMB9	1092.0	-3360
PSMC1	-3206.0	-10570
PSMC2	3803.0	6031
PSMC3	-12761.0	4254
PSMC4	2132.0	1280
PSMC5	-1961.0	1861
PSMC6	-8378.0	6462
PSMD1	-19184.0	-10852
PSMD11	-4049.0	-3275
PSMD12	24.0	-7256
PSMD13	-2337.0	3893
PSMD14	-18126.0	-4800
PSMD2	-6559.0	2157
PSMD3	1361.0	5234
PSMD4	2353.0	1690
PSMD5	-65.5	2411
PSMD6	-17603.0	-12820
PSMD7	2498.0	6265
PSMD8	-9033.0	721
PSMD9	-12004.0	-5850
PSME1	1078.0	7207
PSME2	-464.0	2740
PSME3	1492.0	-773
PSMF1	-5127.0	-498
RBX1	-7728.0	4516
RPS27A	2779.0	3982
SKP1	1474.0	4634
UBA52	-4599.0	1289
UBB	3388.0	1123
UBC	188.0	-1339

---

---

The role of GTSE1 in G2/M progression after G2 checkpoint

The role of GTSE1 in G2/M progression after G2 checkpoint

metric	value
setSize	58
pMANOVA	1.45e-07
p.adjustMANOVA	2.81e-06
s.dist	0.471
s.bl	0.356
s.gu	0.308
p.bl	2.66e-06
p.gu	5.07e-05

Top 20 genes

Gene	bl	gu
PSMC2	3803	6031
PSMD7	2498	6265
PSMA5	2585	5285
RPS27A	2779	3982
PSME1	1078	7207
PSMD3	1361	5234
PSMD4	2353	1690
UBB	3388	1123
PSMC4	2132	1280

Click HERE to show all gene set members

All member genes

	bl	gu
CCNB1	-14474.0	4209.0
CCNB2	-15031.0	670.0
CDK1	-1283.0	-2793.5
CDKN1A	-4543.0	4884.0
FKBPL	-2686.0	-6397.0
GTSE1	-2762.0	-1890.0
HSP90AA1	-3149.0	-3689.0
HSP90AB1	-1015.0	5443.0
MAPRE1	-1085.0	393.0
PLK1	-4741.0	-91.0
PSMA1	-3412.0	3959.0
PSMA2	1412.0	-6569.0
PSMA3	-228.0	2621.0
PSMA4	-1743.0	-555.0
PSMA5	2585.0	5285.0
PSMA6	-6674.0	3459.0
PSMA7	-4079.0	6186.0
PSMA8	-5795.0	-10342.0
PSMB1	469.0	-7922.0
PSMB10	-11837.0	-4265.0
PSMB11	2188.0	-16619.0
PSMB2	-6922.0	3968.0
PSMB3	-3000.0	-1468.0
PSMB4	-371.0	-15631.0
PSMB5	-4730.0	-8797.0
PSMB6	-8722.0	-5248.0
PSMB7	-9915.0	5802.0
PSMB8	-716.0	-5924.0
PSMB9	1092.0	-3360.0
PSMC1	-3206.0	-10570.0
PSMC2	3803.0	6031.0
PSMC3	-12761.0	4254.0
PSMC4	2132.0	1280.0
PSMC5	-1961.0	1861.0
PSMC6	-8378.0	6462.0
PSMD1	-19184.0	-10852.0
PSMD11	-4049.0	-3275.0
PSMD12	24.0	-7256.0
PSMD13	-2337.0	3893.0
PSMD14	-18126.0	-4800.0
PSMD2	-6559.0	2157.0
PSMD3	1361.0	5234.0
PSMD4	2353.0	1690.0
PSMD5	-65.5	2411.0
PSMD6	-17603.0	-12820.0
PSMD7	2498.0	6265.0
PSMD8	-9033.0	721.0
PSMD9	-12004.0	-5850.0
PSME1	1078.0	7207.0
PSME2	-464.0	2740.0
PSME3	1492.0	-773.0
PSME4	-13459.0	-7666.0
PSMF1	-5127.0	-498.0
RPS27A	2779.0	3982.0
TP53	-2299.0	-6686.0
UBA52	-4599.0	1289.0
UBB	3388.0	1123.0
UBC	188.0	-1339.0

---

---

SUMOylation of immune response proteins

SUMOylation of immune response proteins

metric	value
setSize	10
pMANOVA	0.0651
p.adjustMANOVA	0.195
s.dist	0.47
s.bl	0.286
s.gu	0.373
p.bl	0.117
p.gu	0.041

Top 20 genes

Gene	bl	gu
TOPORS	2147	2721.5

Click HERE to show all gene set members

All member genes

	bl	gu
IKBKE	-456	-4044.0
NFKB2	-10502	4607.0
NFKBIA	861	-5349.0
PIAS3	-5498	-5578.0
PIAS4	-10592	4527.0
RELA	-7051	4282.0
SUMO1	3004	-7954.0
SUMO3	-15097	4649.0
TOPORS	2147	2721.5
UBE2I	-5644	-1146.0

---

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

metric	value
setSize	104
pMANOVA	2.76e-13
p.adjustMANOVA	1.52e-11
s.dist	0.467
s.bl	0.41
s.gu	0.223
p.bl	4.97e-13
p.gu	8.24e-05

Top 20 genes

Gene	bl	gu
EIF2S2	3572.0	6992
RPL35A	3401.0	6350
RPL41	3270.0	5146
RPL23	2192.0	6437
RPS27A	2779.0	3982
RPL34	2673.5	3911
RPS19	2386.0	3424
RPS12	3712.0	1981
RPSA	1158.5	3800
RPS17	1109.0	2983
RPL35	423.0	7570
RPS18	1884.0	929
RPS27	108.0	6831
RPL4	3510.0	124
EIF3D	56.0	2540
RPL13	249.0	497

Click HERE to show all gene set members

All member genes

	bl	gu
EIF2S1	-8822.0	-8237.0
EIF2S2	3572.0	6992.0
EIF3A	-12510.0	-8479.0
EIF3B	-3365.0	493.0
EIF3D	56.0	2540.0
EIF3E	-17188.0	1232.0
EIF3F	-11740.0	-12449.0
EIF3G	715.0	-1643.0
EIF3H	-14063.0	-13479.0
EIF3I	-6309.0	-10546.0
EIF3J	-4722.0	-6336.0
EIF3K	2965.0	-5480.0
EIF3L	-11637.0	-8130.0
EIF3M	-1730.0	-1102.0
EIF4A1	-6150.0	1094.0
EIF4A2	1387.0	-15213.0
EIF4B	-12128.0	-7218.0
EIF4E	-1522.0	-10603.0
EIF4G1	-5067.0	-3958.0
EIF4H	-14651.0	2677.0
EIF5	-12770.0	3157.0
EIF5B	404.0	-4203.0
FAU	925.0	-3977.5
RPL10A	-2725.0	1201.0
RPL10L	-17282.0	-14934.0
RPL11	-8184.0	4520.0
RPL12	-4128.0	2724.0
RPL13	249.0	497.0
RPL13A	-4766.5	-7927.5
RPL14	-1225.0	-9732.0
RPL15	-4028.0	2643.0
RPL17	398.0	-12856.0
RPL18	-152.0	6522.0
RPL18A	-498.0	-10349.0
RPL19	-4251.0	3231.0
RPL21	-2014.0	3806.0
RPL22	-6992.0	-5217.0
RPL22L1	-13316.0	-13765.0
RPL23	2192.0	6437.0
RPL23A	49.0	-3660.0
RPL24	-8846.0	4441.0
RPL26	-353.0	5155.0
RPL26L1	-2664.0	-2912.0
RPL27	-3413.0	-1641.0
RPL27A	-628.0	1877.0
RPL28	2808.0	-2646.0
RPL29	-2215.0	1142.0
RPL3	-2551.0	5035.0
RPL30	-2037.0	-7771.0
RPL31	-11010.0	537.0
RPL32	1166.0	-7362.0
RPL34	2673.5	3911.0
RPL35	423.0	7570.0
RPL35A	3401.0	6350.0
RPL36	-2802.0	-3096.0
RPL36AL	-3982.0	3938.0
RPL37	-1931.0	-8725.0
RPL37A	-2812.0	4394.0
RPL38	-10902.0	3642.0
RPL39L	1257.0	-6117.0
RPL3L	-7041.0	-16385.0
RPL4	3510.0	124.0
RPL41	3270.0	5146.0
RPL5	-366.0	-12499.0
RPL6	-5398.0	910.0
RPL7	-1160.0	5094.0
RPL7A	-1890.0	1508.5
RPL8	-1214.0	-4009.0
RPL9	-181.0	-6342.0
RPLP0	-5253.0	-3921.0
RPLP1	-12660.0	-5577.0
RPLP2	-821.0	-6905.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0
UBA52	-4599.0	1289.0

---

---

Hh mutants are degraded by ERAD

Hh mutants are degraded by ERAD

metric	value
setSize	54
pMANOVA	5.85e-07
p.adjustMANOVA	9.32e-06
s.dist	0.466
s.bl	0.349
s.gu	0.309
p.bl	9.11e-06
p.gu	8.65e-05

Top 20 genes

Gene	bl	gu
PSMC2	3803	6031
PSMD7	2498	6265
PSMA5	2585	5285
RPS27A	2779	3982
PSME1	1078	7207
PSMD3	1361	5234
OS9	2813	2421
PSMD4	2353	1690
UBB	3388	1123
PSMC4	2132	1280
ERLEC1	44	2230

Click HERE to show all gene set members

All member genes

	bl	gu
DERL2	1732.0	-2889
ERLEC1	44.0	2230
OS9	2813.0	2421
PSMA1	-3412.0	3959
PSMA2	1412.0	-6569
PSMA3	-228.0	2621
PSMA4	-1743.0	-555
PSMA5	2585.0	5285
PSMA6	-6674.0	3459
PSMA7	-4079.0	6186
PSMA8	-5795.0	-10342
PSMB1	469.0	-7922
PSMB10	-11837.0	-4265
PSMB11	2188.0	-16619
PSMB2	-6922.0	3968
PSMB3	-3000.0	-1468
PSMB4	-371.0	-15631
PSMB5	-4730.0	-8797
PSMB6	-8722.0	-5248
PSMB7	-9915.0	5802
PSMB8	-716.0	-5924
PSMB9	1092.0	-3360
PSMC1	-3206.0	-10570
PSMC2	3803.0	6031
PSMC3	-12761.0	4254
PSMC4	2132.0	1280
PSMC5	-1961.0	1861
PSMC6	-8378.0	6462
PSMD1	-19184.0	-10852
PSMD11	-4049.0	-3275
PSMD12	24.0	-7256
PSMD13	-2337.0	3893
PSMD14	-18126.0	-4800
PSMD2	-6559.0	2157
PSMD3	1361.0	5234
PSMD4	2353.0	1690
PSMD5	-65.5	2411
PSMD6	-17603.0	-12820
PSMD7	2498.0	6265
PSMD8	-9033.0	721
PSMD9	-12004.0	-5850
PSME1	1078.0	7207
PSME2	-464.0	2740
PSME3	1492.0	-773
PSME4	-13459.0	-7666
PSMF1	-5127.0	-498
RPS27A	2779.0	3982
SEL1L	-17071.0	-14813
SHH	-9135.0	1765
SYVN1	-8176.0	5099
UBA52	-4599.0	1289
UBB	3388.0	1123
UBC	188.0	-1339
VCP	-12374.0	5829

---

---

AUF1 (hnRNP D0) binds and destabilizes mRNA

AUF1 (hnRNP D0) binds and destabilizes mRNA

metric	value
setSize	53
pMANOVA	7.67e-07
p.adjustMANOVA	1.17e-05
s.dist	0.466
s.bl	0.353
s.gu	0.304
p.bl	8.89e-06
p.gu	0.000128

Top 20 genes

Gene	bl	gu
PSMC2	3803	6031
PSMD7	2498	6265
HNRNPD	2982	4743
PSMA5	2585	5285
RPS27A	2779	3982
PSME1	1078	7207
PSMD3	1361	5234
PSMD4	2353	1690
UBB	3388	1123
PSMC4	2132	1280

Click HERE to show all gene set members

All member genes

	bl	gu
EIF4G1	-5067.0	-3958
HNRNPD	2982.0	4743
HSPA1A	2506.0	-4510
HSPA8	-3124.0	4881
HSPB1	-13489.0	179
PABPC1	-19383.0	-3729
PSMA1	-3412.0	3959
PSMA2	1412.0	-6569
PSMA3	-228.0	2621
PSMA4	-1743.0	-555
PSMA5	2585.0	5285
PSMA6	-6674.0	3459
PSMA7	-4079.0	6186
PSMA8	-5795.0	-10342
PSMB1	469.0	-7922
PSMB10	-11837.0	-4265
PSMB11	2188.0	-16619
PSMB2	-6922.0	3968
PSMB3	-3000.0	-1468
PSMB4	-371.0	-15631
PSMB5	-4730.0	-8797
PSMB6	-8722.0	-5248
PSMB7	-9915.0	5802
PSMB8	-716.0	-5924
PSMB9	1092.0	-3360
PSMC1	-3206.0	-10570
PSMC2	3803.0	6031
PSMC3	-12761.0	4254
PSMC4	2132.0	1280
PSMC5	-1961.0	1861
PSMC6	-8378.0	6462
PSMD1	-19184.0	-10852
PSMD11	-4049.0	-3275
PSMD12	24.0	-7256
PSMD13	-2337.0	3893
PSMD14	-18126.0	-4800
PSMD2	-6559.0	2157
PSMD3	1361.0	5234
PSMD4	2353.0	1690
PSMD5	-65.5	2411
PSMD6	-17603.0	-12820
PSMD7	2498.0	6265
PSMD8	-9033.0	721
PSMD9	-12004.0	-5850
PSME1	1078.0	7207
PSME2	-464.0	2740
PSME3	1492.0	-773
PSME4	-13459.0	-7666
PSMF1	-5127.0	-498
RPS27A	2779.0	3982
UBA52	-4599.0	1289
UBB	3388.0	1123
UBC	188.0	-1339

---

---

Mitochondrial iron-sulfur cluster biogenesis

Mitochondrial iron-sulfur cluster biogenesis

metric	value
setSize	12
pMANOVA	0.0418
p.adjustMANOVA	0.142
s.dist	0.464
s.bl	0.305
s.gu	0.35
p.bl	0.0675
p.gu	0.0356

Top 20 genes

Gene	bl	gu
ISCU	2193	5476
HSCB	1798	5386

Click HERE to show all gene set members

All member genes

	bl	gu
FDX1	-15627	66
FDXR	-77	-5579
FXN	-9872	84
GLRX5	1187	-1369
HSCB	1798	5386
ISCA1	-4825	4058
ISCA2	3075	-16432
ISCU	2193	5476
LYRM4	-11650	-6025
NFS1	-6949	-1786
SLC25A28	-6558	3843
SLC25A37	-8391	4805

---

---

Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D

metric	value
setSize	50
pMANOVA	1.92e-06
p.adjustMANOVA	2.72e-05
s.dist	0.462
s.bl	0.363
s.gu	0.287
p.bl	9.15e-06
p.gu	0.000447

Top 20 genes

Gene	bl	gu
PSMC2	3803	6031
PSMD7	2498	6265
PSMA5	2585	5285
RPS27A	2779	3982
CDK4	2873	2806
PSME1	1078	7207
PSMD3	1361	5234
PSMD4	2353	1690
UBB	3388	1123
PSMC4	2132	1280

Click HERE to show all gene set members

All member genes

	bl	gu
CCND1	-8891.0	-12
CDK4	2873.0	2806
GSK3B	-11076.0	-12454
PSMA1	-3412.0	3959
PSMA2	1412.0	-6569
PSMA3	-228.0	2621
PSMA4	-1743.0	-555
PSMA5	2585.0	5285
PSMA6	-6674.0	3459
PSMA7	-4079.0	6186
PSMA8	-5795.0	-10342
PSMB1	469.0	-7922
PSMB10	-11837.0	-4265
PSMB11	2188.0	-16619
PSMB2	-6922.0	3968
PSMB3	-3000.0	-1468
PSMB4	-371.0	-15631
PSMB5	-4730.0	-8797
PSMB6	-8722.0	-5248
PSMB7	-9915.0	5802
PSMB8	-716.0	-5924
PSMB9	1092.0	-3360
PSMC1	-3206.0	-10570
PSMC2	3803.0	6031
PSMC3	-12761.0	4254
PSMC4	2132.0	1280
PSMC5	-1961.0	1861
PSMC6	-8378.0	6462
PSMD1	-19184.0	-10852
PSMD11	-4049.0	-3275
PSMD12	24.0	-7256
PSMD13	-2337.0	3893
PSMD14	-18126.0	-4800
PSMD2	-6559.0	2157
PSMD3	1361.0	5234
PSMD4	2353.0	1690
PSMD5	-65.5	2411
PSMD6	-17603.0	-12820
PSMD7	2498.0	6265
PSMD8	-9033.0	721
PSMD9	-12004.0	-5850
PSME1	1078.0	7207
PSME2	-464.0	2740
PSME3	1492.0	-773
PSME4	-13459.0	-7666
PSMF1	-5127.0	-498
RPS27A	2779.0	3982
UBA52	-4599.0	1289
UBB	3388.0	1123
UBC	188.0	-1339

---

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

metric	value
setSize	105
pMANOVA	6.66e-13
p.adjustMANOVA	2.94e-11
s.dist	0.462
s.bl	0.39
s.gu	0.247
p.bl	5.11e-12
p.gu	1.17e-05

Top 20 genes

Gene	bl	gu
RPL35A	3401.0	6350
RPL41	3270.0	5146
RPL23	2192.0	6437
SEC11C	2684.0	4358
RPS27A	2779.0	3982
RPL34	2673.5	3911
RPS19	2386.0	3424
RPS12	3712.0	1981
RPSA	1158.5	3800
RPS17	1109.0	2983
RPL35	423.0	7570
RPS18	1884.0	929
RPS27	108.0	6831
RPL4	3510.0	124
RPL13	249.0	497

Click HERE to show all gene set members

All member genes

	bl	gu
DDOST	-10367.0	-2048.0
FAU	925.0	-3977.5
RPL10A	-2725.0	1201.0
RPL10L	-17282.0	-14934.0
RPL11	-8184.0	4520.0
RPL12	-4128.0	2724.0
RPL13	249.0	497.0
RPL13A	-4766.5	-7927.5
RPL14	-1225.0	-9732.0
RPL15	-4028.0	2643.0
RPL17	398.0	-12856.0
RPL18	-152.0	6522.0
RPL18A	-498.0	-10349.0
RPL19	-4251.0	3231.0
RPL21	-2014.0	3806.0
RPL22	-6992.0	-5217.0
RPL22L1	-13316.0	-13765.0
RPL23	2192.0	6437.0
RPL23A	49.0	-3660.0
RPL24	-8846.0	4441.0
RPL26	-353.0	5155.0
RPL26L1	-2664.0	-2912.0
RPL27	-3413.0	-1641.0
RPL27A	-628.0	1877.0
RPL28	2808.0	-2646.0
RPL29	-2215.0	1142.0
RPL3	-2551.0	5035.0
RPL30	-2037.0	-7771.0
RPL31	-11010.0	537.0
RPL32	1166.0	-7362.0
RPL34	2673.5	3911.0
RPL35	423.0	7570.0
RPL35A	3401.0	6350.0
RPL36	-2802.0	-3096.0
RPL36AL	-3982.0	3938.0
RPL37	-1931.0	-8725.0
RPL37A	-2812.0	4394.0
RPL38	-10902.0	3642.0
RPL39L	1257.0	-6117.0
RPL3L	-7041.0	-16385.0
RPL4	3510.0	124.0
RPL41	3270.0	5146.0
RPL5	-366.0	-12499.0
RPL6	-5398.0	910.0
RPL7	-1160.0	5094.0
RPL7A	-1890.0	1508.5
RPL8	-1214.0	-4009.0
RPL9	-181.0	-6342.0
RPLP0	-5253.0	-3921.0
RPLP1	-12660.0	-5577.0
RPLP2	-821.0	-6905.0
RPN1	-8527.0	3107.0
RPN2	-296.0	-1442.0
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0
SEC11A	-1299.0	4830.0
SEC11C	2684.0	4358.0
SEC61A1	-9318.0	-3536.0
SEC61A2	-17901.0	-11364.0
SEC61B	-6766.5	-758.0
SEC61G	2164.0	-3735.0
SPCS1	-4345.0	3594.0
SPCS2	-3607.0	5096.0
SPCS3	-5549.0	-12237.0
SRP14	262.0	-10175.5
SRP19	536.0	-7154.0
SRP54	1946.0	-11638.0
SRP68	-11958.0	-12611.0
SRP72	-12666.0	-1147.0
SRP9	-9521.0	-7037.0
SRPRB	-16831.0	-3116.0
SSR1	-19253.0	5091.0
SSR2	-6370.0	-6693.0
SSR3	-13036.0	1559.0
TRAM1	-15754.0	-1654.0
UBA52	-4599.0	1289.0

---

---

Vpu mediated degradation of CD4

Vpu mediated degradation of CD4

metric	value
setSize	50
pMANOVA	2.21e-06
p.adjustMANOVA	3.02e-05
s.dist	0.461
s.bl	0.344
s.gu	0.307
p.bl	2.56e-05
p.gu	0.00017

Top 20 genes

Gene	bl	gu
PSMC2	3803	6031
PSMD7	2498	6265
PSMA5	2585	5285
RPS27A	2779	3982
PSME1	1078	7207
PSMD3	1361	5234
SKP1	1474	4634
PSMD4	2353	1690
UBB	3388	1123
PSMC4	2132	1280

Click HERE to show all gene set members

All member genes

	bl	gu
BTRC	-19196.0	-1991
CD4	-11284.0	761
PSMA1	-3412.0	3959
PSMA2	1412.0	-6569
PSMA3	-228.0	2621
PSMA4	-1743.0	-555
PSMA5	2585.0	5285
PSMA6	-6674.0	3459
PSMA7	-4079.0	6186
PSMA8	-5795.0	-10342
PSMB1	469.0	-7922
PSMB10	-11837.0	-4265
PSMB11	2188.0	-16619
PSMB2	-6922.0	3968
PSMB3	-3000.0	-1468
PSMB4	-371.0	-15631
PSMB5	-4730.0	-8797
PSMB6	-8722.0	-5248
PSMB7	-9915.0	5802
PSMB8	-716.0	-5924
PSMB9	1092.0	-3360
PSMC1	-3206.0	-10570
PSMC2	3803.0	6031
PSMC3	-12761.0	4254
PSMC4	2132.0	1280
PSMC5	-1961.0	1861
PSMC6	-8378.0	6462
PSMD1	-19184.0	-10852
PSMD11	-4049.0	-3275
PSMD12	24.0	-7256
PSMD13	-2337.0	3893
PSMD14	-18126.0	-4800
PSMD2	-6559.0	2157
PSMD3	1361.0	5234
PSMD4	2353.0	1690
PSMD5	-65.5	2411
PSMD6	-17603.0	-12820
PSMD7	2498.0	6265
PSMD8	-9033.0	721
PSMD9	-12004.0	-5850
PSME1	1078.0	7207
PSME2	-464.0	2740
PSME3	1492.0	-773
PSME4	-13459.0	-7666
PSMF1	-5127.0	-498
RPS27A	2779.0	3982
SKP1	1474.0	4634
UBA52	-4599.0	1289
UBB	3388.0	1123
UBC	188.0	-1339

---

---

Activation of RAC1

Activation of RAC1

metric	value
setSize	11
pMANOVA	0.045
p.adjustMANOVA	0.15
s.dist	0.461
s.bl	-0.425
s.gu	-0.178
p.bl	0.0146
p.gu	0.306

Top 20 genes

Gene	bl	gu
NCK1	-17050	-13937
ROBO1	-16128	-12358
NCK2	-14838	-12108
PAK2	-18520	-9392
SLIT2	-18970	-6177
SOS2	-16242	-6878
SOS1	-15898	-5922
PAK1	-9683	-7416
PAK4	-5646	-9403

Click HERE to show all gene set members

All member genes

	bl	gu
NCK1	-17050	-13937
NCK2	-14838	-12108
PAK1	-9683	-7416
PAK2	-18520	-9392
PAK4	-5646	-9403
PAK6	-5212	979
RAC1	-16097	1046
ROBO1	-16128	-12358
SLIT2	-18970	-6177
SOS1	-15898	-5922
SOS2	-16242	-6878

---

---

Autodegradation of the E3 ubiquitin ligase COP1

Autodegradation of the E3 ubiquitin ligase COP1

metric	value
setSize	50
pMANOVA	1.99e-06
p.adjustMANOVA	2.78e-05
s.dist	0.461
s.bl	0.367
s.gu	0.279
p.bl	6.93e-06
p.gu	0.000654

Top 20 genes

Gene	bl	gu
PSMC2	3803	6031
PSMD7	2498	6265
PSMA5	2585	5285
RPS27A	2779	3982
PSME1	1078	7207
PSMD3	1361	5234
PSMD4	2353	1690
UBB	3388	1123
PSMC4	2132	1280

Click HERE to show all gene set members

All member genes

	bl	gu
ATM	2590.0	-3415
PSMA1	-3412.0	3959
PSMA2	1412.0	-6569
PSMA3	-228.0	2621
PSMA4	-1743.0	-555
PSMA5	2585.0	5285
PSMA6	-6674.0	3459
PSMA7	-4079.0	6186
PSMA8	-5795.0	-10342
PSMB1	469.0	-7922
PSMB10	-11837.0	-4265
PSMB11	2188.0	-16619
PSMB2	-6922.0	3968
PSMB3	-3000.0	-1468
PSMB4	-371.0	-15631
PSMB5	-4730.0	-8797
PSMB6	-8722.0	-5248
PSMB7	-9915.0	5802
PSMB8	-716.0	-5924
PSMB9	1092.0	-3360
PSMC1	-3206.0	-10570
PSMC2	3803.0	6031
PSMC3	-12761.0	4254
PSMC4	2132.0	1280
PSMC5	-1961.0	1861
PSMC6	-8378.0	6462
PSMD1	-19184.0	-10852
PSMD11	-4049.0	-3275
PSMD12	24.0	-7256
PSMD13	-2337.0	3893
PSMD14	-18126.0	-4800
PSMD2	-6559.0	2157
PSMD3	1361.0	5234
PSMD4	2353.0	1690
PSMD5	-65.5	2411
PSMD6	-17603.0	-12820
PSMD7	2498.0	6265
PSMD8	-9033.0	721
PSMD9	-12004.0	-5850
PSME1	1078.0	7207
PSME2	-464.0	2740
PSME3	1492.0	-773
PSME4	-13459.0	-7666
PSMF1	-5127.0	-498
RFWD2	-14273.0	-4943
RPS27A	2779.0	3982
TP53	-2299.0	-6686
UBA52	-4599.0	1289
UBB	3388.0	1123
UBC	188.0	-1339

---

---

Aberrant regulation of mitotic cell cycle due to RB1 defects

Aberrant regulation of mitotic cell cycle due to RB1 defects

metric	value
setSize	36
pMANOVA	3.19e-05
p.adjustMANOVA	0.000318
s.dist	0.46
s.bl	0.152
s.gu	0.435
p.bl	0.114
p.gu	6.38e-06

Top 20 genes

Gene	bl	gu
ANAPC10	2109	5652
CDK4	2873	2806
ANAPC1	824	3887

Click HERE to show all gene set members

All member genes

	bl	gu
ANAPC1	824	3887.0
ANAPC10	2109	5652.0
ANAPC11	-2940	559.0
ANAPC15	-13367	1632.0
ANAPC16	-2837	3549.0
ANAPC2	-7259	4672.0
ANAPC4	-6445	-2337.0
ANAPC5	-15161	-437.0
ANAPC7	-2356	1878.0
CCND1	-8891	-12.0
CCND2	-4106	-215.0
CCND3	-3520	-571.0
CCNE1	-15507	303.0
CCNE2	-7615	5605.0
CDC16	-1149	-35.5
CDC23	2732	-6247.0
CDC26	-2798	2516.0
CDC27	-16955	-12615.0
CDK2	-7142	-2291.0
CDK4	2873	2806.0
CDK6	-11928	-7135.0
CDKN1A	-4543	4884.0
CDKN1B	-1471	3198.0
CDKN1C	-5811	1646.0
E2F1	-2258	3439.0
E2F2	-2296	2238.0
E2F3	-4616	-996.0
FZR1	-14570	5723.0
RB1	-11978	-4529.0
SKP2	-2600	3840.0
TFDP1	-13600	2870.0
TFDP2	-18428	-1802.0
UBE2C	-1179	-590.0
UBE2D1	-15009	2477.0
UBE2E1	-13606	-5318.0
UBE2S	-4287	-1901.0

---

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

metric	value
setSize	46
pMANOVA	3.43e-06
p.adjustMANOVA	4.31e-05
s.dist	0.458
s.bl	0.414
s.gu	0.195
p.bl	1.14e-06
p.gu	0.0221

Top 20 genes

Gene	bl	gu
EIF2S2	3572.0	6992
RPS27A	2779.0	3982
RPS19	2386.0	3424
RPS12	3712.0	1981
RPSA	1158.5	3800
RPS17	1109.0	2983
RPS18	1884.0	929
RPS27	108.0	6831
EIF3D	56.0	2540

Click HERE to show all gene set members

All member genes

	bl	gu
EIF2S1	-8822.0	-8237.0
EIF2S2	3572.0	6992.0
EIF3A	-12510.0	-8479.0
EIF3B	-3365.0	493.0
EIF3D	56.0	2540.0
EIF3E	-17188.0	1232.0
EIF3F	-11740.0	-12449.0
EIF3G	715.0	-1643.0
EIF3H	-14063.0	-13479.0
EIF3I	-6309.0	-10546.0
EIF3J	-4722.0	-6336.0
EIF3K	2965.0	-5480.0
EIF3L	-11637.0	-8130.0
EIF3M	-1730.0	-1102.0
FAU	925.0	-3977.5
RPS10	-2088.0	1545.0
RPS11	798.0	-16303.0
RPS12	3712.0	1981.0
RPS13	2197.0	-13465.0
RPS14	-589.0	6540.0
RPS15	-4132.0	-1438.0
RPS15A	-5328.0	2607.0
RPS16	-740.0	4122.0
RPS17	1109.0	2983.0
RPS18	1884.0	929.0
RPS19	2386.0	3424.0
RPS2	-4691.0	-6919.0
RPS20	-1196.5	-12290.0
RPS21	702.0	-6009.0
RPS23	1154.0	-1150.0
RPS24	-8255.0	2331.0
RPS25	1541.0	-987.0
RPS26	-6362.0	6532.0
RPS27	108.0	6831.0
RPS27A	2779.0	3982.0
RPS27L	1133.0	-5329.0
RPS28	-11779.0	3028.0
RPS29	2459.0	-10294.0
RPS3	-5395.5	1888.0
RPS3A	-929.0	2226.0
RPS5	541.0	-15111.0
RPS6	-9781.0	-511.0
RPS7	-7993.0	-11980.0
RPS8	-8456.0	5697.5
RPS9	-11078.0	-10694.0
RPSA	1158.5	3800.0

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.2 Patched (2022-11-10 r83330)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      parallel  stats4    stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.2                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.4.0                                      
##  [4] gtools_3.9.4                                       
##  [5] tibble_3.1.8                                       
##  [6] dplyr_1.0.10                                       
##  [7] echarts4r_0.4.4                                    
##  [8] vioplot_0.4.0                                      
##  [9] zoo_1.8-11                                         
## [10] sm_2.2-5.7.1                                       
## [11] tictoc_1.1                                         
## [12] RIdeogram_0.2.2                                    
## [13] kableExtra_1.3.4                                   
## [14] data.table_1.14.6                                  
## [15] ENmix_1.34.0                                       
## [16] doParallel_1.0.17                                  
## [17] qqman_0.1.8                                        
## [18] RCircos_1.2.2                                      
## [19] beeswarm_0.4.0                                     
## [20] forestplot_3.1.1                                   
## [21] abind_1.4-5                                        
## [22] checkmate_2.1.0                                    
## [23] reshape2_1.4.4                                     
## [24] gplots_3.1.3                                       
## [25] eulerr_7.0.0                                       
## [26] GEOquery_2.66.0                                    
## [27] RColorBrewer_1.1-3                                 
## [28] IlluminaHumanMethylation450kmanifest_0.4.0         
## [29] topconfects_1.14.0                                 
## [30] DMRcatedata_2.16.0                                 
## [31] ExperimentHub_2.6.0                                
## [32] AnnotationHub_3.6.0                                
## [33] BiocFileCache_2.6.0                                
## [34] dbplyr_2.3.0                                       
## [35] limma_3.54.0                                       
## [36] missMethyl_1.32.0                                  
## [37] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [38] R.utils_2.12.2                                     
## [39] R.oo_1.25.0                                        
## [40] R.methodsS3_1.8.2                                  
## [41] plyr_1.8.8                                         
## [42] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [43] mitch_1.10.0                                       
## [44] ebGSEA_0.1.0                                       
## [45] ChAMP_2.28.0                                       
## [46] RPMM_1.25                                          
## [47] cluster_2.1.4                                      
## [48] DT_0.27                                            
## [49] IlluminaHumanMethylationEPICmanifest_0.3.0         
## [50] Illumina450ProbeVariants.db_1.34.0                 
## [51] DMRcate_2.12.0                                     
## [52] ChAMPdata_2.30.0                                   
## [53] minfi_1.44.0                                       
## [54] bumphunter_1.40.0                                  
## [55] locfit_1.5-9.7                                     
## [56] iterators_1.0.14                                   
## [57] foreach_1.5.2                                      
## [58] Biostrings_2.66.0                                  
## [59] XVector_0.38.0                                     
## [60] SummarizedExperiment_1.28.0                        
## [61] Biobase_2.58.0                                     
## [62] MatrixGenerics_1.10.0                              
## [63] matrixStats_0.63.0                                 
## [64] GenomicRanges_1.50.2                               
## [65] GenomeInfoDb_1.34.6                                
## [66] IRanges_2.32.0                                     
## [67] S4Vectors_0.36.1                                   
## [68] BiocGenerics_0.44.0                                
## [69] EBSEA_1.26.0                                       
## [70] globaltest_5.52.0                                  
## [71] survival_3.5-0                                     
## 
## loaded via a namespace (and not attached):
##   [1] svglite_2.1.1                 Hmisc_4.7-2                  
##   [3] rsvg_2.4.0                    Rsamtools_2.14.0             
##   [5] crayon_1.5.2                  MASS_7.3-58.2                
##   [7] rhdf5filters_1.10.0           nlme_3.1-161                 
##   [9] backports_1.4.1               sva_3.46.0                   
##  [11] impute_1.72.3                 rlang_1.0.6                  
##  [13] readxl_1.4.1                  DSS_2.46.0                   
##  [15] filelock_1.0.2                BiocParallel_1.32.5          
##  [17] rjson_0.2.21                  bit64_4.0.5                  
##  [19] glue_1.6.2                    isva_1.9                     
##  [21] rngtools_1.5.2                methylumi_2.44.0             
##  [23] AnnotationDbi_1.60.0          tidyselect_1.2.0             
##  [25] XML_3.99-0.13                 nleqslv_3.3.4                
##  [27] tidyr_1.2.1                   calibrate_1.7.7              
##  [29] GenomicAlignments_1.34.0      xtable_1.8-4                 
##  [31] magrittr_2.0.3                evaluate_0.20                
##  [33] cli_3.6.0                     zlibbioc_1.44.0              
##  [35] grImport2_0.2-0               rstudioapi_0.14              
##  [37] doRNG_1.8.6                   bslib_0.4.2                  
##  [39] rpart_4.1.19                  ensembldb_2.22.0             
##  [41] shiny_1.7.4                   xfun_0.36                    
##  [43] askpass_1.1                   clue_0.3-63                  
##  [45] multtest_2.54.0               caTools_1.18.2               
##  [47] KEGGREST_1.38.0               interactiveDisplayBase_1.36.0
##  [49] base64_2.0.1                  biovizBase_1.46.0            
##  [51] scrime_1.3.5                  dendextend_1.16.0            
##  [53] png_0.1-8                     permute_0.9-7                
##  [55] reshape_0.8.9                 withr_2.5.0                  
##  [57] lumi_2.50.0                   bitops_1.0-7                 
##  [59] cellranger_1.1.0              AnnotationFilter_1.22.0      
##  [61] JADE_2.0-3                    pillar_1.8.1                 
##  [63] cachem_1.0.6                  GenomicFeatures_1.50.3       
##  [65] DelayedMatrixStats_1.20.0     vctrs_0.5.2                  
##  [67] ellipsis_0.3.2                generics_0.1.3               
##  [69] tools_4.2.2                   EmpiricalBrownsMethod_1.26.0 
##  [71] foreign_0.8-84                munsell_0.5.0                
##  [73] DelayedArray_0.24.0           fastmap_1.1.0                
##  [75] compiler_4.2.2                httpuv_1.6.8                 
##  [77] rtracklayer_1.58.0            geneLenDataBase_1.34.0       
##  [79] beanplot_1.3.1                Gviz_1.42.0                  
##  [81] plotly_4.10.1                 GenomeInfoDbData_1.2.9       
##  [83] gridExtra_2.3                 DNAcopy_1.72.3               
##  [85] edgeR_3.40.2                  lattice_0.20-45              
##  [87] deldir_1.0-6                  utf8_1.2.2                   
##  [89] later_1.3.0                   jsonlite_1.8.4               
##  [91] affy_1.76.0                   scales_1.2.1                 
##  [93] sparseMatrixStats_1.10.0      genefilter_1.80.3            
##  [95] lazyeval_0.2.2                promises_1.2.0.1             
##  [97] latticeExtra_0.6-30           goseq_1.50.0                 
##  [99] rmarkdown_2.20                nor1mix_1.3-0                
## [101] webshot_0.5.4                 statmod_1.5.0                
## [103] siggenes_1.72.0               dichromat_2.0-0.1            
## [105] BSgenome_1.66.2               HDF5Array_1.26.0             
## [107] bsseq_1.34.0                  yaml_2.3.7                   
## [109] systemfonts_1.0.4             htmltools_0.5.4              
## [111] memoise_2.0.1                 VariantAnnotation_1.44.0     
## [113] BiocIO_1.8.0                  quadprog_1.5-8               
## [115] viridisLite_0.4.1             digest_0.6.31                
## [117] assertthat_0.2.1              mime_0.12                    
## [119] rappdirs_0.3.3                BiasedUrn_2.0.8              
## [121] RSQLite_2.2.20                blob_1.2.3                   
## [123] preprocessCore_1.60.2         labeling_0.4.2               
## [125] fastICA_1.2-3                 shinythemes_1.2.0            
## [127] splines_4.2.2                 Formula_1.2-4                
## [129] Rhdf5lib_1.20.0               illuminaio_0.40.0            
## [131] ProtGenerics_1.30.0           RCurl_1.98-1.9               
## [133] hms_1.1.2                     rhdf5_2.42.0                 
## [135] colorspace_2.1-0              base64enc_0.1-3              
## [137] BiocManager_1.30.19           nnet_7.3-18                  
## [139] sass_0.4.5                    Rcpp_1.0.10                  
## [141] mclust_6.0.0                  fansi_1.0.4                  
## [143] tzdb_0.3.0                    R6_2.5.1                     
## [145] lifecycle_1.0.3               curl_5.0.0                   
## [147] kpmt_0.1.0                    affyio_1.68.0                
## [149] jquerylib_0.1.4               Matrix_1.5-3                 
## [151] qvalue_2.30.0                 ROC_1.74.0                   
## [153] org.Hs.eg.db_3.16.0           stringr_1.5.0                
## [155] htmlwidgets_1.6.1             biomaRt_2.54.0               
## [157] purrr_1.0.1                   marray_1.76.0                
## [159] rvest_1.0.3                   mgcv_1.8-41                  
## [161] openssl_2.0.5                 htmlTable_2.4.1              
## [163] codetools_0.2-18              GO.db_3.16.0                 
## [165] prettyunits_1.1.1             gtable_0.3.1                 
## [167] DBI_1.1.3                     dynamicTreeCut_1.63-1        
## [169] wateRmelon_2.4.0              highr_0.10                   
## [171] httr_1.4.4                    KernSmooth_2.23-20           
## [173] stringi_1.7.12                progress_1.2.2               
## [175] farver_2.1.1                  annotate_1.76.0              
## [177] viridis_0.6.2                 xml2_1.3.3                   
## [179] combinat_0.0-8                restfulr_0.0.15              
## [181] interp_1.1-3                  readr_2.1.3                  
## [183] geneplotter_1.76.0            BiocVersion_3.16.0           
## [185] DESeq2_1.38.3                 bit_4.0.5                    
## [187] jpeg_0.1-10                   pkgconfig_2.0.3              
## [189] knitr_1.41

END of report