Source: https://github.com/markziemann/asd_meth/cohort_characterisation.Rmd
library("kableExtra")
library("magrittr")Clinical characterisation of the cohort, shown in table 1 of the manuscript.
There are 3 samplesheets provided. Separate ones for blood and guthrie and also a combined one where the
19 ASD_blood_summarysheet.csv 40 ASD_guthrie_blood_combined_summarysheet.csv 23 ASD_guthrie_summarysheet.csv
datg <- read.table("ASD_guthrie_summarysheet.csv",sep=",",header=TRUE)
datb <- read.table("ASD_blood_summarysheet.csv",sep=",",header=TRUE)
dat <- datg
dat$Guthrie_sample <- TRUE
dat$Blood_sample <- datg$SampleName %in% datb$Sample_Name
dat %>%
kbl(caption="Full sample sheet of the anonymous participant data") %>%
kable_paper("hover", full_width = FALSE)| SampleID | ChipID | Sentrix_ID | Sentrix_Position | SampleName | Sex | Age_months | Age_years | Birth_mode | Birth_complications | gestational_age | Birth_weight.g. | Birth_order | Help_breathing_start | Motor_skills | Social_interaction_on_ADOS | Diagnosis | SRS_social_scores | language | IQ | Family_ID | Guthrie_sample | Blood_sample |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S3 | 202047860135_R03C01 | 202047860135 | R03C01 | ASD001.1 | 1 | 163 | 17 | 1 | 0 | 35.0 | 2112.000 | 1 | 1 | 2 | 3 | 0 | 103 | 53 | 62 | 1 | TRUE | TRUE |
| S4 | 202047860135_R04C01 | 202047860135 | R04C01 | ASD001.2 | 1 | 163 | 17 | 1 | 0 | 35.0 | 2680.000 | 2 | 1 | 2 | 12 | 2 | 121 | 61 | 68 | 1 | TRUE | TRUE |
| S31 | 202010290151_R07C01 | 202010290151 | R07C01 | ASD002.1 | 2 | 95 | 11 | 1 | 0 | 36.0 | 2240.000 | 1 | 0 | 2 | 9 | 1 | 84 | 113 | 98 | 2 | TRUE | TRUE |
| S32 | 202010290151_R08C01 | 202010290151 | R08C01 | ASD002.2 | 2 | 95 | 11 | 1 | 0 | 36.0 | 3395.000 | 2 | 0 | 0 | 13 | 2 | 47 | 113 | 105 | 2 | TRUE | TRUE |
| S11 | 202013790140_R03C01 | 202013790140 | R03C01 | ASD003.1 | 1 | 44 | 7 | 1 | 0 | 36.0 | 2220.000 | 2 | 1 | 1 | 15 | 2 | 74 | 102 | 110 | 3 | TRUE | TRUE |
| S12 | 202013790140_R04C01 | 202013790140 | R04C01 | ASD003.2 | 1 | 44 | 7 | 1 | 0 | 36.0 | 2020.000 | 1 | 1 | 1 | 12 | 1 | 94 | 108 | 103 | 3 | TRUE | TRUE |
| S13 | 202013790140_R05C01 | 202013790140 | R05C01 | ASD004.1 | 2 | 80 | 10 | 1 | 0 | 36.7 | 2400.000 | 1 | 0 | 0 | 1 | 0 | 35 | 99 | 94 | 4 | TRUE | TRUE |
| S14 | 202013790140_R06C01 | 202013790140 | R06C01 | ASD004.2 | 2 | 80 | 10 | 1 | 0 | 36.7 | 1900.000 | 2 | 0 | 0 | 8 | 1 | 61 | 66 | 67 | 4 | TRUE | TRUE |
| S17 | 202010290146_R01C01 | 202010290146 | R01C01 | ASD005.1 | 1 | 73 | 8 | 2 | 0 | 37.5 | 2296.000 | 1 | 0 | 0 | 16 | 2 | 95 | 50 | 0 | 5 | TRUE | FALSE |
| S18 | 202010290146_R02C01 | 202010290146 | R02C01 | ASD005.2 | 1 | 73 | 8 | 2 | 3 | 37.5 | 3120.000 | 2 | 1 | 0 | 5 | 0 | 79 | 68 | 102 | 5 | TRUE | FALSE |
| S21 | 202010290146_R05C01 | 202010290146 | R05C01 | ASD006.1 | 1 | 37 | 5 | 1 | 0 | 36.4 | 2400.000 | 1 | 0 | 0 | 16 | 2 | 125 | 50 | 53 | 6 | TRUE | TRUE |
| S22 | 202010290146_R06C01 | 202010290146 | R06C01 | ASD006.2 | 1 | 37 | 5 | 1 | 0 | 36.4 | 2.500 | 2 | 0 | 0 | 11 | 1 | 73 | 81 | 86 | 6 | TRUE | TRUE |
| S27 | 202010290151_R03C01 | 202010290151 | R03C01 | ASD007.1 | 2 | 131 | 14 | 0 | 3 | 34.0 | 1927.700 | 1 | 0 | 2 | 10 | 2 | 78 | 66 | 71 | 7 | TRUE | TRUE |
| S28 | 202010290151_R04C01 | 202010290151 | R04C01 | ASD007.2 | 2 | 10 | 14 | 3 | 3 | 34.0 | 1814.000 | 2 | 0 | 2 | 18 | 2 | 100 | 50 | 62 | 7 | TRUE | TRUE |
| S7 | 202047860135_R07C01 | 202047860135 | R07C01 | ASD008.1 | 2 | 69 | 8 | 1 | 0 | 37.0 | 2610.000 | 1 | 0 | 2 | 18 | 2 | 111 | 50 | 60 | 8 | TRUE | TRUE |
| S8 | 202047860135_R08C01 | 202047860135 | R08C01 | ASD008.2 | 2 | 69 | 8 | 1 | 0 | 37.0 | 2684.000 | 2 | 0 | 2 | 20 | 2 | 104 | 50 | 64 | 8 | TRUE | TRUE |
| S23 | 202010290146_R07C01 | 202010290146 | R07C01 | ASD009.1 | 2 | 41 | 6 | 2 | 1 | 31.0 | 1817.000 | 1 | 1 | 2 | 7 | 0 | 102 | 95 | 100 | 9 | TRUE | FALSE |
| S24 | 202010290146_R08C01 | 202010290146 | R08C01 | ASD009.2 | 2 | 41 | 6 | 2 | 1 | 31.0 | 2093.000 | 2 | 1 | 2 | 9 | 1 | 127 | 87 | 105 | 9 | TRUE | FALSE |
| S39 | 202010290176_R07C01 | 202010290176 | R07C01 | ASD012.1 | 2 | 136 | 13 | 1 | 0 | 38.0 | 2336.001 | 1 | 0 | 0 | 17 | 2 | 45 | 99 | 88 | 12 | TRUE | TRUE |
| S40 | 202010290176_R08C01 | 202010290176 | R08C01 | ASD012.2 | 2 | 136 | 13 | 1 | 0 | 38.0 | 2630.840 | 2 | 0 | 0 | 12 | 1 | 52 | 79 | 80 | 12 | TRUE | TRUE |
| S35 | 202010290176_R03C01 | 202010290176 | R03C01 | ASD013.1 | 2 | 12 | 13 | 2 | 2 | 31.0 | 1551.000 | 1 | 1 | 0 | 1 | 0 | 4 | 120 | 106 | 13 | TRUE | TRUE |
| S36 | 202010290176_R04C01 | 202010290176 | R04C01 | ASD013.2 | 2 | 146 | 13 | 2 | 2 | 31.0 | 1055.000 | 2 | 1 | 0 | 13 | 2 | 34 | 41 | 60 | 13 | TRUE | TRUE |
Provide some summary statistics for the Guthrie arm of the project.
message("summary stats")## summary statssummary(datg)## SampleID ChipID Sentrix_ID Sentrix_Position
## Length:22 Length:22 Min. :2.02e+11 Length:22
## Class :character Class :character 1st Qu.:2.02e+11 Class :character
## Mode :character Mode :character Median :2.02e+11 Mode :character
## Mean :2.02e+11
## 3rd Qu.:2.02e+11
## Max. :2.02e+11
## SampleName Sex Age_months Age_years
## Length:22 Min. :1.000 Min. : 10.00 Min. : 5.00
## Class :character 1st Qu.:1.000 1st Qu.: 41.75 1st Qu.: 7.25
## Mode :character Median :2.000 Median : 73.00 Median :10.00
## Mean :1.636 Mean : 80.68 Mean :10.18
## 3rd Qu.:2.000 3rd Qu.:122.00 3rd Qu.:13.00
## Max. :2.000 Max. :163.00 Max. :17.00
## Birth_mode Birth_complications gestational_age Birth_weight.g.
## Min. :0.000 Min. :0.0000 Min. :31.00 Min. : 2.5
## 1st Qu.:1.000 1st Qu.:0.0000 1st Qu.:34.25 1st Qu.:1906.9
## Median :1.000 Median :0.0000 Median :36.00 Median :2230.0
## Mean :1.318 Mean :0.6818 Mean :35.33 Mean :2150.2
## 3rd Qu.:2.000 3rd Qu.:1.0000 3rd Qu.:36.92 3rd Qu.:2557.5
## Max. :3.000 Max. :3.0000 Max. :38.00 Max. :3395.0
## Birth_order Help_breathing_start Motor_skills Social_interaction_on_ADOS
## Min. :1.0 Min. :0.0000 Min. :0.0000 Min. : 1.00
## 1st Qu.:1.0 1st Qu.:0.0000 1st Qu.:0.0000 1st Qu.: 8.25
## Median :1.5 Median :0.0000 Median :0.5000 Median :12.00
## Mean :1.5 Mean :0.4091 Mean :0.9091 Mean :11.18
## 3rd Qu.:2.0 3rd Qu.:1.0000 3rd Qu.:2.0000 3rd Qu.:15.75
## Max. :2.0 Max. :1.0000 Max. :2.0000 Max. :20.00
## Diagnosis SRS_social_scores language IQ
## Min. :0.000 Min. : 4.00 Min. : 41.00 Min. : 0.00
## 1st Qu.:1.000 1st Qu.: 54.25 1st Qu.: 50.75 1st Qu.: 62.50
## Median :1.500 Median : 81.50 Median : 73.50 Median : 83.00
## Mean :1.273 Mean : 79.45 Mean : 77.32 Mean : 79.27
## 3rd Qu.:2.000 3rd Qu.:102.75 3rd Qu.: 99.00 3rd Qu.:101.50
## Max. :2.000 Max. :127.00 Max. :120.00 Max. :110.00
## Family_ID
## Min. : 1.000
## 1st Qu.: 3.250
## Median : 6.000
## Mean : 6.364
## 3rd Qu.: 8.750
## Max. :13.000message("standard deviation")## standard deviationmysd <- apply(datg,2,sd)## Warning in var(if (is.vector(x) || is.factor(x)) x else as.double(x), na.rm =
## na.rm): NAs introduced by coercion
## Warning in var(if (is.vector(x) || is.factor(x)) x else as.double(x), na.rm =
## na.rm): NAs introduced by coercion
## Warning in var(if (is.vector(x) || is.factor(x)) x else as.double(x), na.rm =
## na.rm): NAs introduced by coercion
## Warning in var(if (is.vector(x) || is.factor(x)) x else as.double(x), na.rm =
## na.rm): NAs introduced by coercionformat(mysd,scientific=FALSE)## SampleID ChipID
## " NA" " NA"
## Sentrix_ID Sentrix_Position
## "14586836.0205855" " NA"
## SampleName Sex
## " NA" " 0.4923660"
## Age_months Age_years
## " 47.1283823" " 3.6727616"
## Birth_mode Birth_complications
## " 0.6463350" " 1.1291111"
## gestational_age Birth_weight.g.
## " 2.3486940" " 697.6346866"
## Birth_order Help_breathing_start
## " 0.5117663" " 0.5032363"
## Motor_skills Social_interaction_on_ADOS
## " 0.9714540" " 5.4566374"
## Diagnosis SRS_social_scores
## " 0.8270325" " 32.9223144"
## language IQ
## " 25.3853846" " 25.8883718"
## Family_ID
## " 3.8115795"message("categorical counts")## categorical countsmytab <- apply(datg,2,table)
mytab## $SampleID
##
## S11 S12 S13 S14 S17 S18 S21 S22 S23 S24 S27 S28 S3 S31 S32 S35 S36 S39 S4 S40
## 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
## S7 S8
## 1 1
##
## $ChipID
##
## 202010290146_R01C01 202010290146_R02C01 202010290146_R05C01 202010290146_R06C01
## 1 1 1 1
## 202010290146_R07C01 202010290146_R08C01 202010290151_R03C01 202010290151_R04C01
## 1 1 1 1
## 202010290151_R07C01 202010290151_R08C01 202010290176_R03C01 202010290176_R04C01
## 1 1 1 1
## 202010290176_R07C01 202010290176_R08C01 202013790140_R03C01 202013790140_R04C01
## 1 1 1 1
## 202013790140_R05C01 202013790140_R06C01 202047860135_R03C01 202047860135_R04C01
## 1 1 1 1
## 202047860135_R07C01 202047860135_R08C01
## 1 1
##
## $Sentrix_ID
##
## 202010290146 202010290151 202010290176 202013790140 202047860135
## 6 4 4 4 4
##
## $Sentrix_Position
##
## R01C01 R02C01 R03C01 R04C01 R05C01 R06C01 R07C01 R08C01
## 1 1 4 4 2 2 4 4
##
## $SampleName
##
## ASD001.1 ASD001.2 ASD002.1 ASD002.2 ASD003.1 ASD003.2 ASD004.1 ASD004.2
## 1 1 1 1 1 1 1 1
## ASD005.1 ASD005.2 ASD006.1 ASD006.2 ASD007.1 ASD007.2 ASD008.1 ASD008.2
## 1 1 1 1 1 1 1 1
## ASD009.1 ASD009.2 ASD012.1 ASD012.2 ASD013.1 ASD013.2
## 1 1 1 1 1 1
##
## $Sex
##
## 1 2
## 8 14
##
## $Age_months
##
## 10 12 37 41 44 69 73 80 95 131 136 146 163
## 1 1 2 2 2 2 2 2 2 1 2 1 2
##
## $Age_years
##
## 5 6 7 8 10 11 13 14 17
## 2 2 2 4 2 2 4 2 2
##
## $Birth_mode
##
## 0 1 2 3
## 1 14 6 1
##
## $Birth_complications
##
## 0 1 2 3
## 15 2 2 3
##
## $gestational_age
##
## 31.0 34.0 35.0 36.0 36.4 36.7 37.0 37.5 38.0
## 4 2 2 4 2 2 2 2 2
##
## $Birth_weight.g.
##
## 2.500 1055.000 1551.000 1814.000 1817.000 1900.000 1927.700 2020.000
## 1 1 1 1 1 1 1 1
## 2093.000 2112.000 2220.000 2240.000 2296.000 2336.001 2400.000 2610.000
## 1 1 1 1 1 1 2 1
## 2630.840 2680.000 2684.000 3120.000 3395.000
## 1 1 1 1 1
##
## $Birth_order
##
## 1 2
## 11 11
##
## $Help_breathing_start
##
## 0 1
## 13 9
##
## $Motor_skills
##
## 0 1 2
## 11 2 9
##
## $Social_interaction_on_ADOS
##
## 1 3 5 7 8 9 10 11 12 13 15 16 17 18 20
## 2 1 1 1 1 2 1 1 3 2 1 2 1 2 1
##
## $Diagnosis
##
## 0 1 2
## 5 6 11
##
## $SRS_social_scores
##
## 4 34 35 45 47 52 61 73 74 78 79 84 94 95 100 102 103 104 111 121
## 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
## 125 127
## 1 1
##
## $language
##
## 41 50 53 61 66 68 79 81 87 95 99 102 108 113 120
## 1 5 1 1 2 1 1 1 1 1 2 1 1 2 1
##
## $IQ
##
## 0 53 60 62 64 67 68 71 80 86 88 94 98 100 102 103 105 106 110
## 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1
##
## $Family_ID
##
## 1 2 3 4 5 6 7 8 9 12 13
## 2 2 2 2 2 2 2 2 2 2 2Now for the follow-up blood samples.
message("summary stats")## summary statssummary(datb)## SampleID ChipID Sentrix_ID Sentrix_Position
## Length:18 Length:18 Min. :2.02e+11 Length:18
## Class :character Class :character 1st Qu.:2.02e+11 Class :character
## Mode :character Mode :character Median :2.02e+11 Mode :character
## Mean :2.02e+11
## 3rd Qu.:2.02e+11
## Max. :2.02e+11
## Sample_Name Sex Age_months Age_years
## Length:18 Min. :1.000 Min. : 10.00 Min. : 5.00
## Class :character 1st Qu.:1.000 1st Qu.: 44.00 1st Qu.: 8.00
## Mode :character Median :2.000 Median : 80.00 Median :11.00
## Mean :1.667 Mean : 85.94 Mean :10.89
## 3rd Qu.:2.000 3rd Qu.:134.75 3rd Qu.:13.00
## Max. :2.000 Max. :163.00 Max. :17.00
## Birth_mode Birth_complications gestational_age Birth_weight.g.
## Min. :0.000 Min. :0.0000 Min. :31.00 Min. : 2.5
## 1st Qu.:1.000 1st Qu.:0.0000 1st Qu.:35.00 1st Qu.:1906.9
## Median :1.000 Median :0.0000 Median :36.00 Median :2230.0
## Mean :1.167 Mean :0.5556 Mean :35.57 Mean :2109.9
## 3rd Qu.:1.000 3rd Qu.:0.0000 3rd Qu.:36.70 3rd Qu.:2557.5
## Max. :3.000 Max. :3.0000 Max. :38.00 Max. :3395.0
## Birth_order Help_breathing_start Motor_skills Social_interaction_on_ADOS
## Min. :1.0 Min. :0.0000 Min. :0.0000 Min. : 1.00
## 1st Qu.:1.0 1st Qu.:0.0000 1st Qu.:0.0000 1st Qu.: 9.25
## Median :1.5 Median :0.0000 Median :0.5000 Median :12.00
## Mean :1.5 Mean :0.3333 Mean :0.8889 Mean :11.61
## 3rd Qu.:2.0 3rd Qu.:1.0000 3rd Qu.:2.0000 3rd Qu.:15.75
## Max. :2.0 Max. :1.0000 Max. :2.0000 Max. :20.00
## Diagnosis SRS_social_scores language IQ
## Min. :0.000 Min. : 4.00 Min. : 41.00 Min. : 53.00
## 1st Qu.:1.000 1st Qu.: 48.25 1st Qu.: 50.75 1st Qu.: 62.50
## Median :2.000 Median : 76.00 Median : 72.50 Median : 75.50
## Mean :1.389 Mean : 74.72 Mean : 77.83 Mean : 79.83
## 3rd Qu.:2.000 3rd Qu.:102.25 3rd Qu.:101.25 3rd Qu.: 97.00
## Max. :2.000 Max. :125.00 Max. :120.00 Max. :110.00
## Family_ID
## Min. : 1.000
## 1st Qu.: 3.000
## Median : 6.000
## Mean : 6.222
## 3rd Qu.: 8.000
## Max. :13.000message("standard deviation")## standard deviationmysd <- apply(datb,2,sd)## Warning in var(if (is.vector(x) || is.factor(x)) x else as.double(x), na.rm =
## na.rm): NAs introduced by coercion
## Warning in var(if (is.vector(x) || is.factor(x)) x else as.double(x), na.rm =
## na.rm): NAs introduced by coercion
## Warning in var(if (is.vector(x) || is.factor(x)) x else as.double(x), na.rm =
## na.rm): NAs introduced by coercion
## Warning in var(if (is.vector(x) || is.factor(x)) x else as.double(x), na.rm =
## na.rm): NAs introduced by coercionformat(mysd,scientific=FALSE)## SampleID ChipID
## " NA" " NA"
## Sentrix_ID Sentrix_Position
## "15710030.5380391" " NA"
## Sample_Name Sex
## " NA" " 0.4850713"
## Age_months Age_years
## " 50.2212425" " 3.6764575"
## Birth_mode Birth_complications
## " 0.6183469" " 1.0966378"
## gestational_age Birth_weight.g.
## " 1.9988232" " 732.2514469"
## Birth_order Help_breathing_start
## " 0.5144958" " 0.4850713"
## Motor_skills Social_interaction_on_ADOS
## " 0.9633818" " 5.6270240"
## Diagnosis SRS_social_scores
## " 0.7775443" " 33.7356602"
## language IQ
## " 26.8859246" " 19.0610474"
## Family_ID
## " 4.1096093"message("categorical counts")## categorical countsmytab <- apply(datb,2,table)
mytab## $SampleID
##
## S1 S10 S15 S16 S19 S2 S20 S25 S26 S29 S30 S33 S34 S37 S38 S5 S6 S9
## 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
##
## $ChipID
##
## 202010290146_R03C01 202010290146_R04C01 202010290151_R01C01 202010290151_R02C01
## 1 1 1 1
## 202010290151_R05C01 202010290151_R06C01 202010290176_R01C01 202010290176_R02C01
## 1 1 1 1
## 202010290176_R05C01 202010290176_R06C01 202013790140_R01C01 202013790140_R02C01
## 1 1 1 1
## 202013790140_R07C01 202013790140_R08C01 202047860135_R01C01 202047860135_R02C01
## 1 1 1 1
## 202047860135_R05C01 202047860135_R06C01
## 1 1
##
## $Sentrix_ID
##
## 202010290146 202010290151 202010290176 202013790140 202047860135
## 2 4 4 4 4
##
## $Sentrix_Position
##
## R01C01 R02C01 R03C01 R04C01 R05C01 R06C01 R07C01 R08C01
## 4 4 1 1 3 3 1 1
##
## $Sample_Name
##
## ASD001.1 ASD001.2 ASD002.1 ASD002.2 ASD003.1 ASD003.2 ASD004.1 ASD004.2
## 1 1 1 1 1 1 1 1
## ASD006.1 ASD006.2 ASD007.1 ASD007.2 ASD008.1 ASD008.2 ASD012.1 ASD012.2
## 1 1 1 1 1 1 1 1
## ASD013.1 ASD013.2
## 1 1
##
## $Sex
##
## 1 2
## 6 12
##
## $Age_months
##
## 10 12 37 44 69 80 95 131 136 146 163
## 1 1 2 2 2 2 2 1 2 1 2
##
## $Age_years
##
## 5 7 8 10 11 13 14 17
## 2 2 2 2 2 4 2 2
##
## $Birth_mode
##
## 0 1 2 3
## 1 14 2 1
##
## $Birth_complications
##
## 0 2 3
## 14 2 2
##
## $gestational_age
##
## 31.0 34.0 35.0 36.0 36.4 36.7 37.0 38.0
## 2 2 2 4 2 2 2 2
##
## $Birth_weight.g.
##
## 2.500 1055.000 1551.000 1814.000 1900.000 1927.700 2020.000 2112.000
## 1 1 1 1 1 1 1 1
## 2220.000 2240.000 2336.001 2400.000 2610.000 2630.840 2680.000 2684.000
## 1 1 1 2 1 1 1 1
## 3395.000
## 1
##
## $Birth_order
##
## 1 2
## 9 9
##
## $Help_breathing_start
##
## 0 1
## 12 6
##
## $Motor_skills
##
## 0 1 2
## 9 2 7
##
## $Social_interaction_on_ADOS
##
## 1 3 8 9 10 11 12 13 15 16 17 18 20
## 2 1 1 1 1 1 3 2 1 1 1 2 1
##
## $Diagnosis
##
## 0 1 2
## 3 5 10
##
## $SRS_social_scores
##
## 4 34 35 45 47 52 61 73 74 78 84 94 100 103 104 111 121 125
## 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
##
## $language
##
## 41 50 53 61 66 79 81 99 102 108 113 120
## 1 4 1 1 2 1 1 2 1 1 2 1
##
## $IQ
##
## 53 60 62 64 67 68 71 80 86 88 94 98 103 105 106 110
## 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1
##
## $Family_ID
##
## 1 2 3 4 6 7 8 12 13
## 2 2 2 2 2 2 2 2 2sessionInfo()## R version 4.2.2 Patched (2022-11-10 r83330)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] stats graphics grDevices utils datasets methods base
##
## other attached packages:
## [1] magrittr_2.0.3 kableExtra_1.3.4
##
## loaded via a namespace (and not attached):
## [1] rstudioapi_0.14 knitr_1.41 xml2_1.3.3 munsell_0.5.0
## [5] rvest_1.0.3 viridisLite_0.4.1 colorspace_2.0-3 R6_2.5.1
## [9] rlang_1.0.6 fastmap_1.1.0 highr_0.9 stringr_1.5.0
## [13] httr_1.4.4 tools_4.2.2 webshot_0.5.4 xfun_0.35
## [17] cli_3.4.1 jquerylib_0.1.4 systemfonts_1.0.4 htmltools_0.5.4
## [21] yaml_2.3.6 digest_0.6.31 lifecycle_1.0.3 sass_0.4.4
## [25] vctrs_0.5.1 glue_1.6.2 cachem_1.0.6 evaluate_0.19
## [29] rmarkdown_2.19 stringi_1.7.8 compiler_4.2.2 bslib_0.4.2
## [33] scales_1.2.1 svglite_2.1.0 jsonlite_1.8.4