Mitch Report

date generated: 2022-10-15

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    t        fry
## A1BG     -0.08338947 -0.1865151
## A1BG-AS1  0.05475914  0.1708984
## A1CF     -0.51895782 -0.9863933
## A2BP1    -0.84205677 -0.4879107
## A2LD1    -0.09367611 -0.1458347
## A2M      -4.54554802 -0.5801419

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	25739
duplicated_genes_present	0
num_profile_genes_in_sets	10218
num_profile_genes_not_in_sets	15521
profile_pearson_correl	0.46932
profile_spearman_correl	0.7967

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2584
num_genesets_excluded	1038
num_genesets_included	1546

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 334

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.t	s.fry	p.t	p.fry
Activation of RAC1	11	1.62e-04	1.61e-03	0.931	-0.727	-0.581	2.94e-05	8.50e-04
Eicosanoids	12	2.49e-04	2.28e-03	0.909	0.633	0.653	1.46e-04	9.03e-05
Apoptotic cleavage of cell adhesion proteins	11	3.21e-03	1.94e-02	0.788	-0.575	-0.539	9.67e-04	1.97e-03
Carnitine metabolism	11	1.20e-02	5.49e-02	0.682	-0.514	-0.449	3.18e-03	9.97e-03
SARS-CoV-1 modulates host translation machinery	34	1.72e-07	5.55e-06	0.674	0.548	0.392	3.17e-08	7.52e-05
ALK mutants bind TKIs	12	1.33e-02	5.94e-02	0.650	-0.434	-0.483	9.22e-03	3.73e-03
Regulation of TP53 Activity through Association with Co-factors	14	2.16e-05	3.56e-04	0.626	-0.586	-0.219	1.45e-04	1.55e-01
CASP8 activity is inhibited	11	2.00e-02	8.18e-02	0.601	0.355	0.484	4.14e-02	5.41e-03
Dimerization of procaspase-8	11	2.00e-02	8.18e-02	0.601	0.355	0.484	4.14e-02	5.41e-03
Regulation by c-FLIP	11	2.00e-02	8.18e-02	0.601	0.355	0.484	4.14e-02	5.41e-03
Peptide chain elongation	84	6.09e-12	5.89e-10	0.583	0.453	0.367	6.72e-13	5.92e-09
Pexophagy	11	4.34e-02	1.43e-01	0.583	0.402	0.423	2.10e-02	1.52e-02
MET activates PTK2 signaling	18	9.21e-05	1.00e-03	0.583	-0.523	-0.257	1.21e-04	5.94e-02
VEGFR2 mediated vascular permeability	26	7.32e-07	2.10e-05	0.571	-0.521	-0.233	4.16e-06	3.93e-02
Eukaryotic Translation Elongation	88	7.06e-12	6.06e-10	0.569	0.441	0.359	7.86e-13	5.74e-09
Eukaryotic Translation Termination	87	6.72e-12	6.06e-10	0.567	0.445	0.351	7.36e-13	1.45e-08
RHOJ GTPase cycle	51	4.06e-07	1.23e-05	0.560	-0.439	-0.348	5.79e-08	1.72e-05
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	6.94e-03	3.60e-02	0.560	-0.471	-0.302	2.26e-03	5.01e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	16	1.54e-02	6.74e-02	0.559	-0.391	-0.399	6.80e-03	5.67e-03
Selenocysteine synthesis	87	2.77e-11	2.14e-09	0.558	0.432	0.353	3.19e-12	1.28e-08
Fatty acids	15	8.84e-03	4.32e-02	0.557	0.454	0.323	2.33e-03	3.04e-02
MET activates RAS signaling	11	4.00e-02	1.36e-01	0.555	-0.441	-0.338	1.13e-02	5.26e-02
Free fatty acids regulate insulin secretion	10	1.70e-02	7.23e-02	0.552	-0.483	-0.267	8.13e-03	1.44e-01
Viral mRNA Translation	84	8.38e-11	4.63e-09	0.552	0.430	0.346	9.65e-12	4.18e-08
RHOU GTPase cycle	37	2.57e-05	3.94e-04	0.551	-0.436	-0.337	4.35e-06	3.86e-04
RHOV GTPase cycle	36	9.56e-05	1.03e-03	0.551	-0.407	-0.371	2.39e-05	1.14e-04
TICAM1-dependent activation of IRF3/IRF7	12	4.94e-02	1.56e-01	0.547	0.377	0.396	2.35e-02	1.76e-02
PRC2 methylates histones and DNA	13	3.83e-02	1.32e-01	0.539	-0.355	-0.406	2.65e-02	1.13e-02
TICAM1,TRAF6-dependent induction of TAK1 complex	10	8.52e-02	2.29e-01	0.538	0.360	0.399	4.84e-02	2.88e-02
Laminin interactions	23	7.51e-05	8.41e-04	0.537	-0.477	-0.247	7.52e-05	4.00e-02
Acetylcholine regulates insulin secretion	10	5.81e-02	1.76e-01	0.536	-0.433	-0.316	1.77e-02	8.37e-02
Termination of O-glycan biosynthesis	25	4.60e-04	3.84e-03	0.534	-0.443	-0.297	1.24e-04	1.00e-02
MET activates RAP1 and RAC1	11	7.36e-02	2.09e-01	0.530	-0.389	-0.360	2.55e-02	3.86e-02
Autodegradation of the E3 ubiquitin ligase COP1	50	9.13e-06	1.90e-04	0.528	0.374	0.372	4.62e-06	5.36e-06
Assembly of the ORC complex at the origin of replication	10	6.43e-02	1.91e-01	0.527	-0.311	-0.425	8.85e-02	1.99e-02
Synthesis of PIPs at the plasma membrane	48	1.22e-05	2.35e-04	0.526	-0.391	-0.352	2.73e-06	2.45e-05
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	4.87e-06	1.14e-04	0.526	0.366	0.377	4.02e-06	1.98e-06
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	3.91e-11	2.88e-09	0.525	0.411	0.327	4.42e-12	3.58e-08
Regulation of RUNX1 Expression and Activity	25	3.01e-04	2.72e-03	0.524	-0.446	-0.275	1.13e-04	1.72e-02
MECP2 regulates neuronal receptors and channels	17	2.09e-02	8.47e-02	0.521	-0.375	-0.362	7.35e-03	9.79e-03
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	3.78e-05	5.12e-04	0.520	-0.407	-0.324	6.39e-06	3.33e-04
Formation of a pool of free 40S subunits	94	4.21e-11	2.88e-09	0.520	0.412	0.317	4.98e-12	1.03e-07
RHO GTPases activate IQGAPs	11	3.95e-02	1.35e-01	0.518	-0.432	-0.285	1.31e-02	1.01e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	1.67e-05	2.99e-04	0.516	-0.426	-0.291	4.06e-06	1.68e-03
Scavenging of heme from plasma	12	3.64e-02	1.27e-01	0.514	-0.423	-0.292	1.12e-02	7.96e-02
Thyroxine biosynthesis	10	1.06e-01	2.60e-01	0.511	-0.383	-0.338	3.59e-02	6.40e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	3.26e-10	1.57e-08	0.510	0.405	0.311	4.04e-11	3.88e-07
Vif-mediated degradation of APOBEC3G	50	1.97e-05	3.40e-04	0.509	0.352	0.368	1.66e-05	6.84e-06
Uptake and function of anthrax toxins	11	9.08e-02	2.38e-01	0.509	-0.372	-0.347	3.26e-02	4.64e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	3.44e-05	4.75e-04	0.507	0.355	0.361	2.05e-05	1.48e-05

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.t	s.fry	p.t	p.fry
Activation of RAC1	11	1.62e-04	1.61e-03	0.93100	-0.727000	-5.81e-01	2.94e-05	8.50e-04
Eicosanoids	12	2.49e-04	2.28e-03	0.90900	0.633000	6.53e-01	1.46e-04	9.03e-05
Apoptotic cleavage of cell adhesion proteins	11	3.21e-03	1.94e-02	0.78800	-0.575000	-5.39e-01	9.67e-04	1.97e-03
Carnitine metabolism	11	1.20e-02	5.49e-02	0.68200	-0.514000	-4.49e-01	3.18e-03	9.97e-03
SARS-CoV-1 modulates host translation machinery	34	1.72e-07	5.55e-06	0.67400	0.548000	3.92e-01	3.17e-08	7.52e-05
ALK mutants bind TKIs	12	1.33e-02	5.94e-02	0.65000	-0.434000	-4.83e-01	9.22e-03	3.73e-03
Regulation of TP53 Activity through Association with Co-factors	14	2.16e-05	3.56e-04	0.62600	-0.586000	-2.19e-01	1.45e-04	1.55e-01
CASP8 activity is inhibited	11	2.00e-02	8.18e-02	0.60100	0.355000	4.84e-01	4.14e-02	5.41e-03
Dimerization of procaspase-8	11	2.00e-02	8.18e-02	0.60100	0.355000	4.84e-01	4.14e-02	5.41e-03
Regulation by c-FLIP	11	2.00e-02	8.18e-02	0.60100	0.355000	4.84e-01	4.14e-02	5.41e-03
Peptide chain elongation	84	6.09e-12	5.89e-10	0.58300	0.453000	3.67e-01	6.72e-13	5.92e-09
Pexophagy	11	4.34e-02	1.43e-01	0.58300	0.402000	4.23e-01	2.10e-02	1.52e-02
MET activates PTK2 signaling	18	9.21e-05	1.00e-03	0.58300	-0.523000	-2.57e-01	1.21e-04	5.94e-02
VEGFR2 mediated vascular permeability	26	7.32e-07	2.10e-05	0.57100	-0.521000	-2.33e-01	4.16e-06	3.93e-02
Eukaryotic Translation Elongation	88	7.06e-12	6.06e-10	0.56900	0.441000	3.59e-01	7.86e-13	5.74e-09
Eukaryotic Translation Termination	87	6.72e-12	6.06e-10	0.56700	0.445000	3.51e-01	7.36e-13	1.45e-08
RHOJ GTPase cycle	51	4.06e-07	1.23e-05	0.56000	-0.439000	-3.48e-01	5.79e-08	1.72e-05
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	6.94e-03	3.60e-02	0.56000	-0.471000	-3.02e-01	2.26e-03	5.01e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	16	1.54e-02	6.74e-02	0.55900	-0.391000	-3.99e-01	6.80e-03	5.67e-03
Selenocysteine synthesis	87	2.77e-11	2.14e-09	0.55800	0.432000	3.53e-01	3.19e-12	1.28e-08
Fatty acids	15	8.84e-03	4.32e-02	0.55700	0.454000	3.23e-01	2.33e-03	3.04e-02
MET activates RAS signaling	11	4.00e-02	1.36e-01	0.55500	-0.441000	-3.38e-01	1.13e-02	5.26e-02
Free fatty acids regulate insulin secretion	10	1.70e-02	7.23e-02	0.55200	-0.483000	-2.67e-01	8.13e-03	1.44e-01
Viral mRNA Translation	84	8.38e-11	4.63e-09	0.55200	0.430000	3.46e-01	9.65e-12	4.18e-08
RHOU GTPase cycle	37	2.57e-05	3.94e-04	0.55100	-0.436000	-3.37e-01	4.35e-06	3.86e-04
RHOV GTPase cycle	36	9.56e-05	1.03e-03	0.55100	-0.407000	-3.71e-01	2.39e-05	1.14e-04
TICAM1-dependent activation of IRF3/IRF7	12	4.94e-02	1.56e-01	0.54700	0.377000	3.96e-01	2.35e-02	1.76e-02
PRC2 methylates histones and DNA	13	3.83e-02	1.32e-01	0.53900	-0.355000	-4.06e-01	2.65e-02	1.13e-02
TICAM1,TRAF6-dependent induction of TAK1 complex	10	8.52e-02	2.29e-01	0.53800	0.360000	3.99e-01	4.84e-02	2.88e-02
Laminin interactions	23	7.51e-05	8.41e-04	0.53700	-0.477000	-2.47e-01	7.52e-05	4.00e-02
Acetylcholine regulates insulin secretion	10	5.81e-02	1.76e-01	0.53600	-0.433000	-3.16e-01	1.77e-02	8.37e-02
Termination of O-glycan biosynthesis	25	4.60e-04	3.84e-03	0.53400	-0.443000	-2.97e-01	1.24e-04	1.00e-02
MET activates RAP1 and RAC1	11	7.36e-02	2.09e-01	0.53000	-0.389000	-3.60e-01	2.55e-02	3.86e-02
Autodegradation of the E3 ubiquitin ligase COP1	50	9.13e-06	1.90e-04	0.52800	0.374000	3.72e-01	4.62e-06	5.36e-06
Assembly of the ORC complex at the origin of replication	10	6.43e-02	1.91e-01	0.52700	-0.311000	-4.25e-01	8.85e-02	1.99e-02
Synthesis of PIPs at the plasma membrane	48	1.22e-05	2.35e-04	0.52600	-0.391000	-3.52e-01	2.73e-06	2.45e-05
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	4.87e-06	1.14e-04	0.52600	0.366000	3.77e-01	4.02e-06	1.98e-06
Response of EIF2AK4 (GCN2) to amino acid deficiency	95	3.91e-11	2.88e-09	0.52500	0.411000	3.27e-01	4.42e-12	3.58e-08
Regulation of RUNX1 Expression and Activity	25	3.01e-04	2.72e-03	0.52400	-0.446000	-2.75e-01	1.13e-04	1.72e-02
MECP2 regulates neuronal receptors and channels	17	2.09e-02	8.47e-02	0.52100	-0.375000	-3.62e-01	7.35e-03	9.79e-03
Sensory perception of sweet, bitter, and umami (glutamate) taste	41	3.78e-05	5.12e-04	0.52000	-0.407000	-3.24e-01	6.39e-06	3.33e-04
Formation of a pool of free 40S subunits	94	4.21e-11	2.88e-09	0.52000	0.412000	3.17e-01	4.98e-12	1.03e-07
RHO GTPases activate IQGAPs	11	3.95e-02	1.35e-01	0.51800	-0.432000	-2.85e-01	1.31e-02	1.01e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	39	1.67e-05	2.99e-04	0.51600	-0.426000	-2.91e-01	4.06e-06	1.68e-03
Scavenging of heme from plasma	12	3.64e-02	1.27e-01	0.51400	-0.423000	-2.92e-01	1.12e-02	7.96e-02
Thyroxine biosynthesis	10	1.06e-01	2.60e-01	0.51100	-0.383000	-3.38e-01	3.59e-02	6.40e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	89	3.26e-10	1.57e-08	0.51000	0.405000	3.11e-01	4.04e-11	3.88e-07
Vif-mediated degradation of APOBEC3G	50	1.97e-05	3.40e-04	0.50900	0.352000	3.68e-01	1.66e-05	6.84e-06
Uptake and function of anthrax toxins	11	9.08e-02	2.38e-01	0.50900	-0.372000	-3.47e-01	3.26e-02	4.64e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	3.44e-05	4.75e-04	0.50700	0.355000	3.61e-01	2.05e-05	1.48e-05
Vpu mediated degradation of CD4	50	2.25e-05	3.67e-04	0.50600	0.353000	3.63e-01	1.55e-05	8.97e-06
Ubiquitin-dependent degradation of Cyclin D	50	2.30e-05	3.67e-04	0.50600	0.364000	3.51e-01	8.59e-06	1.72e-05
Recycling pathway of L1	23	4.55e-03	2.59e-02	0.50600	-0.395000	-3.15e-01	1.02e-03	8.92e-03
SRP-dependent cotranslational protein targeting to membrane	105	5.37e-11	3.20e-09	0.50400	0.387000	3.23e-01	6.66e-12	1.08e-08
Cross-presentation of soluble exogenous antigens (endosomes)	46	6.80e-05	7.79e-04	0.50000	0.353000	3.54e-01	3.34e-05	3.25e-05
Role of LAT2/NTAL/LAB on calcium mobilization	13	3.42e-02	1.22e-01	0.49900	-0.410000	-2.84e-01	1.04e-02	7.64e-02
DCC mediated attractive signaling	14	2.50e-02	9.77e-02	0.49600	-0.411000	-2.78e-01	7.73e-03	7.17e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	3.36e-05	4.68e-04	0.49600	0.360000	3.41e-01	1.05e-05	3.09e-05
p53-Independent DNA Damage Response	50	3.36e-05	4.68e-04	0.49600	0.360000	3.41e-01	1.05e-05	3.09e-05
p53-Independent G1/S DNA damage checkpoint	50	3.36e-05	4.68e-04	0.49600	0.360000	3.41e-01	1.05e-05	3.09e-05
Hh mutants are degraded by ERAD	54	1.60e-05	2.94e-04	0.49500	0.357000	3.43e-01	5.74e-06	1.32e-05
MET promotes cell motility	29	6.92e-05	7.81e-04	0.49200	-0.433000	-2.35e-01	5.46e-05	2.86e-02
Beta defensins	28	3.14e-03	1.90e-02	0.48900	0.324000	3.67e-01	3.03e-03	7.73e-04
Mucopolysaccharidoses	10	7.85e-02	2.18e-01	0.48700	-0.404000	-2.72e-01	2.70e-02	1.36e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	2.77e-05	4.15e-04	0.48700	0.339000	3.50e-01	1.94e-05	1.06e-05
SUMOylation of DNA methylation proteins	16	4.16e-02	1.39e-01	0.48700	-0.353000	-3.36e-01	1.46e-02	2.01e-02
Formation of the ternary complex, and subsequently, the 43S complex	46	3.10e-06	7.61e-05	0.48600	0.412000	2.57e-01	1.29e-06	2.55e-03
Signaling by WNT in cancer	32	1.11e-03	8.01e-03	0.48500	-0.377000	-3.05e-01	2.26e-04	2.83e-03
Aspartate and asparagine metabolism	11	9.41e-02	2.44e-01	0.48400	-0.378000	-3.02e-01	2.97e-02	8.27e-02
SCF(Skp2)-mediated degradation of p27/p21	58	1.23e-05	2.35e-04	0.48400	0.341000	3.43e-01	7.18e-06	6.05e-06
Presynaptic depolarization and calcium channel opening	12	3.59e-02	1.26e-01	0.48200	-0.411000	-2.52e-01	1.36e-02	1.31e-01
Notch-HLH transcription pathway	24	2.30e-03	1.50e-02	0.48100	-0.401000	-2.66e-01	6.66e-04	2.41e-02
L13a-mediated translational silencing of Ceruloplasmin expression	103	1.77e-10	9.45e-09	0.48100	0.381000	2.93e-01	2.18e-11	2.80e-07
RHOQ GTPase cycle	57	7.51e-07	2.11e-05	0.48000	-0.398000	-2.68e-01	1.96e-07	4.65e-04
VEGFR2 mediated cell proliferation	19	7.92e-03	4.01e-02	0.47800	-0.401000	-2.61e-01	2.49e-03	4.90e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	104	4.51e-11	2.88e-09	0.47800	0.388000	2.79e-01	7.69e-12	9.08e-07
Stabilization of p53	55	2.93e-05	4.32e-04	0.47700	0.342000	3.32e-01	1.14e-05	2.02e-05
SCF-beta-TrCP mediated degradation of Emi1	53	4.69e-05	5.95e-04	0.47500	0.332000	3.40e-01	2.91e-05	1.89e-05
Metabolism of amine-derived hormones	17	3.71e-02	1.29e-01	0.47400	-0.356000	-3.12e-01	1.09e-02	2.59e-02
Defective GALNT3 causes HFTC	18	1.56e-02	6.76e-02	0.47000	-0.387000	-2.68e-01	4.47e-03	4.94e-02
Selenoamino acid metabolism	103	1.27e-09	5.32e-08	0.47000	0.365000	2.96e-01	1.57e-10	2.07e-07
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	50	1.05e-04	1.11e-03	0.46800	0.339000	3.22e-01	3.32e-05	8.19e-05
SARS-CoV-2 modulates host translation machinery	46	2.23e-06	5.76e-05	0.46600	0.406000	2.30e-01	1.89e-06	7.02e-03
Cap-dependent Translation Initiation	111	4.65e-11	2.88e-09	0.46400	0.376000	2.72e-01	7.51e-12	7.37e-07
Eukaryotic Translation Initiation	111	4.65e-11	2.88e-09	0.46400	0.376000	2.72e-01	7.51e-12	7.37e-07
The role of GTSE1 in G2/M progression after G2 checkpoint	58	2.82e-05	4.19e-04	0.45900	0.343000	3.05e-01	6.04e-06	5.76e-05
Dectin-2 family	28	7.19e-04	5.50e-03	0.45900	-0.394000	-2.35e-01	3.05e-04	3.14e-02
APC/C:Cdc20 mediated degradation of Securin	66	9.56e-06	1.92e-04	0.45800	0.326000	3.22e-01	4.63e-06	5.84e-06
Regulation of commissural axon pathfinding by SLIT and ROBO	10	1.05e-01	2.59e-01	0.45800	-0.380000	-2.55e-01	3.75e-02	1.62e-01
Negative regulation of NOTCH4 signaling	52	9.06e-05	9.93e-04	0.45700	0.302000	3.42e-01	1.64e-04	1.93e-05
Defective C1GALT1C1 causes TNPS	18	8.40e-03	4.20e-02	0.45600	-0.395000	-2.28e-01	3.67e-03	9.40e-02
Chemokine receptors bind chemokines	56	6.04e-05	7.12e-04	0.45300	0.334000	3.06e-01	1.54e-05	7.39e-05
Myogenesis	29	5.52e-03	2.98e-02	0.45000	-0.345000	-2.89e-01	1.29e-03	7.14e-03
Endosomal/Vacuolar pathway	12	1.04e-01	2.59e-01	0.44900	0.275000	3.54e-01	9.88e-02	3.35e-02
Elevation of cytosolic Ca2+ levels	16	6.68e-03	3.50e-02	0.44800	-0.404000	-1.94e-01	5.09e-03	1.80e-01
DSCAM interactions	11	1.35e-01	3.06e-01	0.44800	-0.349000	-2.82e-01	4.53e-02	1.06e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	5.71e-02	1.74e-01	0.44500	-0.388000	-2.17e-01	2.59e-02	2.12e-01
Autodegradation of Cdh1 by Cdh1:APC/C	62	3.75e-05	5.12e-04	0.44400	0.312000	3.16e-01	2.16e-05	1.64e-05
Regulation of RUNX3 expression and activity	53	1.66e-04	1.63e-03	0.44300	0.307000	3.20e-01	1.09e-04	5.68e-05
RORA activates gene expression	17	3.66e-03	2.15e-02	0.44300	-0.405000	-1.80e-01	3.83e-03	2.00e-01
Non-integrin membrane-ECM interactions	40	2.97e-04	2.70e-03	0.44300	-0.363000	-2.53e-01	6.97e-05	5.54e-03
Defective GALNT12 causes CRCS1	18	1.32e-02	5.93e-02	0.44200	-0.380000	-2.26e-01	5.26e-03	9.69e-02
Glucuronidation	25	2.01e-03	1.33e-02	0.44000	-0.219000	-3.82e-01	5.81e-02	9.46e-04
Defensins	36	2.66e-03	1.66e-02	0.43900	0.327000	2.93e-01	6.77e-04	2.35e-03
Regulation of innate immune responses to cytosolic DNA	14	1.06e-01	2.60e-01	0.43900	0.312000	3.08e-01	4.29e-02	4.62e-02
Defective CFTR causes cystic fibrosis	59	3.96e-05	5.33e-04	0.43800	0.338000	2.78e-01	6.85e-06	2.17e-04
Signaling by PDGFR in disease	20	3.56e-02	1.25e-01	0.43800	-0.332000	-2.85e-01	1.02e-02	2.71e-02
Adherens junctions interactions	26	7.98e-03	4.02e-02	0.43700	-0.351000	-2.61e-01	1.95e-03	2.10e-02
Hh mutants abrogate ligand secretion	57	1.07e-04	1.13e-03	0.43700	0.318000	2.99e-01	3.19e-05	9.20e-05
TICAM1, RIP1-mediated IKK complex recruitment	18	5.70e-02	1.74e-01	0.43500	0.317000	2.98e-01	1.99e-02	2.86e-02
Ketone body metabolism	10	1.89e-01	3.73e-01	0.43400	-0.279000	-3.33e-01	1.26e-01	6.86e-02
Reactions specific to the complex N-glycan synthesis pathway	10	5.74e-02	1.74e-01	0.43400	-0.390000	-1.92e-01	3.29e-02	2.94e-01
Synthesis of PIPs at the late endosome membrane	10	2.06e-01	3.88e-01	0.43300	-0.317000	-2.96e-01	8.30e-02	1.05e-01
PLC beta mediated events	47	6.21e-06	1.39e-04	0.43200	-0.380000	-2.06e-01	6.45e-06	1.46e-02
G-protein mediated events	52	6.97e-06	1.52e-04	0.43200	-0.371000	-2.21e-01	3.73e-06	5.81e-03
Gap junction degradation	10	1.55e-01	3.34e-01	0.43100	-0.350000	-2.52e-01	5.53e-02	1.67e-01
Tie2 Signaling	18	2.82e-02	1.07e-01	0.43100	-0.357000	-2.42e-01	8.74e-03	7.52e-02
Methylation	14	1.09e-01	2.66e-01	0.43000	0.287000	3.21e-01	6.34e-02	3.76e-02
Degradation of GLI2 by the proteasome	58	1.30e-04	1.34e-03	0.43000	0.302000	3.06e-01	6.75e-05	5.54e-05
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	12	1.27e-01	2.93e-01	0.43000	-0.338000	-2.65e-01	4.23e-02	1.12e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	1.59e-05	2.94e-04	0.42900	0.303000	3.04e-01	8.55e-06	8.20e-06
MET receptor recycling	10	2.13e-01	3.96e-01	0.42900	-0.312000	-2.95e-01	8.78e-02	1.07e-01
Major pathway of rRNA processing in the nucleolus and cytosol	171	6.06e-14	1.04e-11	0.42800	0.344000	2.54e-01	8.08e-15	9.68e-09
Degradation of DVL	55	2.39e-04	2.20e-03	0.42700	0.302000	3.02e-01	1.08e-04	1.09e-04
Platelet Adhesion to exposed collagen	13	2.44e-03	1.57e-02	0.42700	-0.413000	-1.05e-01	9.84e-03	5.12e-01
Cleavage of the damaged purine	11	1.76e-01	3.59e-01	0.42600	-0.278000	-3.23e-01	1.11e-01	6.35e-02
Depurination	11	1.76e-01	3.59e-01	0.42600	-0.278000	-3.23e-01	1.11e-01	6.35e-02
Recognition and association of DNA glycosylase with site containing an affected purine	11	1.76e-01	3.59e-01	0.42600	-0.278000	-3.23e-01	1.11e-01	6.35e-02
SUMOylation of intracellular receptors	29	1.84e-04	1.73e-03	0.42500	-0.387000	-1.76e-01	3.06e-04	1.01e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	1.21e-02	5.49e-02	0.42500	-0.323000	-2.77e-01	3.10e-03	1.12e-02
Regulation of ornithine decarboxylase (ODC)	49	6.03e-04	4.73e-03	0.42500	0.294000	3.08e-01	3.76e-04	1.95e-04
Induction of Cell-Cell Fusion	12	4.01e-02	1.36e-01	0.42500	-0.380000	-1.91e-01	2.27e-02	2.53e-01
RHOB GTPase cycle	66	3.66e-07	1.13e-05	0.42400	-0.366000	-2.15e-01	2.69e-07	2.52e-03
GLI3 is processed to GLI3R by the proteasome	58	1.66e-04	1.63e-03	0.42400	0.300000	3.00e-01	7.84e-05	7.51e-05
Regulation of Apoptosis	51	4.73e-04	3.93e-03	0.42300	0.291000	3.07e-01	3.18e-04	1.48e-04
Signaling by Hippo	19	4.60e-02	1.49e-01	0.42000	-0.262000	-3.29e-01	4.79e-02	1.31e-02
Synthesis of PIPs at the early endosome membrane	15	1.08e-01	2.65e-01	0.41900	-0.307000	-2.86e-01	3.95e-02	5.53e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.10e-03	8.01e-03	0.41900	-0.037400	-4.17e-01	8.30e-01	1.65e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	54	1.89e-05	3.33e-04	0.41500	0.353000	2.20e-01	7.34e-06	5.19e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	108	5.26e-09	2.04e-07	0.41400	0.339000	2.38e-01	1.07e-09	1.93e-05
Nonsense-Mediated Decay (NMD)	108	5.26e-09	2.04e-07	0.41400	0.339000	2.38e-01	1.07e-09	1.93e-05
Netrin-1 signaling	49	5.61e-04	4.54e-03	0.41400	-0.319000	-2.65e-01	1.12e-04	1.35e-03
Pyrimidine salvage	10	1.75e-01	3.59e-01	0.41400	-0.338000	-2.40e-01	6.44e-02	1.89e-01
Sensory perception of taste	47	4.31e-04	3.66e-03	0.41300	-0.331000	-2.47e-01	8.72e-05	3.36e-03
Nephrin family interactions	21	3.43e-02	1.22e-01	0.41200	-0.327000	-2.51e-01	9.49e-03	4.65e-02
Translation initiation complex formation	53	2.41e-05	3.76e-04	0.41000	0.350000	2.14e-01	1.05e-05	7.15e-03
Metabolism of polyamines	55	4.56e-04	3.83e-03	0.40900	0.283000	2.95e-01	2.78e-04	1.53e-04
E2F mediated regulation of DNA replication	20	6.21e-02	1.85e-01	0.40800	-0.289000	-2.88e-01	2.54e-02	2.55e-02
Integrin signaling	27	4.19e-03	2.42e-02	0.40800	-0.350000	-2.10e-01	1.66e-03	5.94e-02
rRNA processing in the nucleus and cytosol	180	1.11e-13	1.71e-11	0.40700	0.331000	2.38e-01	1.86e-14	3.76e-08
Activation of the phototransduction cascade	11	5.31e-03	2.91e-02	0.40700	-0.400000	-7.81e-02	2.18e-02	6.54e-01
Neurexins and neuroligins	52	4.78e-05	6.00e-04	0.40600	-0.344000	-2.16e-01	1.74e-05	7.00e-03
Chondroitin sulfate biosynthesis	18	7.36e-02	2.09e-01	0.40600	-0.310000	-2.63e-01	2.28e-02	5.36e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	5.53e-05	6.68e-04	0.40600	0.294000	2.80e-01	1.83e-05	4.36e-05
Heme signaling	45	3.79e-04	3.29e-03	0.40600	-0.336000	-2.29e-01	9.69e-05	7.97e-03
Ribosomal scanning and start codon recognition	53	9.89e-06	1.96e-04	0.40600	0.355000	1.98e-01	7.95e-06	1.26e-02
PI Metabolism	79	5.62e-06	1.30e-04	0.40600	-0.320000	-2.50e-01	8.83e-07	1.20e-04
VEGFA-VEGFR2 Pathway	93	9.91e-10	4.38e-08	0.40600	-0.356000	-1.94e-01	2.78e-09	1.20e-03
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	2.20e-01	4.05e-01	0.40600	-0.286000	-2.88e-01	1.01e-01	9.78e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37	5.67e-03	3.05e-02	0.40500	-0.301000	-2.70e-01	1.51e-03	4.44e-03
Antimicrobial peptides	78	9.57e-06	1.92e-04	0.40400	0.253000	3.15e-01	1.12e-04	1.53e-06
Effects of PIP2 hydrolysis	26	9.44e-03	4.55e-02	0.40400	-0.337000	-2.22e-01	2.92e-03	5.03e-02
Syndecan interactions	19	7.58e-02	2.13e-01	0.40300	-0.283000	-2.88e-01	3.28e-02	3.00e-02
p53-Dependent G1 DNA Damage Response	64	1.79e-04	1.73e-03	0.40200	0.284000	2.84e-01	8.25e-05	8.24e-05
p53-Dependent G1/S DNA damage checkpoint	64	1.79e-04	1.73e-03	0.40200	0.284000	2.84e-01	8.25e-05	8.24e-05
Tryptophan catabolism	12	1.56e-01	3.36e-01	0.40100	-0.321000	-2.42e-01	5.45e-02	1.47e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	6.44e-05	7.44e-04	0.40100	0.288000	2.79e-01	2.35e-05	4.34e-05
Transcriptional Regulation by MECP2	60	3.09e-05	4.42e-04	0.40100	-0.333000	-2.23e-01	8.18e-06	2.81e-03
RHOC GTPase cycle	69	9.23e-06	1.90e-04	0.39900	-0.329000	-2.25e-01	2.21e-06	1.22e-03
Degradation of GLI1 by the proteasome	58	4.35e-04	3.68e-03	0.39900	0.274000	2.90e-01	3.08e-04	1.32e-04
Activation of the TFAP2 (AP-2) family of transcription factors	11	1.19e-01	2.80e-01	0.39800	0.204000	3.41e-01	2.41e-01	4.99e-02
RAC2 GTPase cycle	80	6.90e-06	1.52e-04	0.39600	-0.315000	-2.40e-01	1.13e-06	2.05e-04
Degradation of AXIN	53	1.01e-03	7.44e-03	0.39500	0.280000	2.79e-01	4.20e-04	4.39e-04
Signaling by VEGF	101	8.70e-10	3.95e-08	0.39500	-0.345000	-1.91e-01	2.01e-09	8.80e-04
Processive synthesis on the C-strand of the telomere	19	1.60e-02	6.89e-02	0.39300	-0.183000	-3.48e-01	1.67e-01	8.66e-03
RHO GTPases activate KTN1	11	2.19e-01	4.04e-01	0.39200	-0.303000	-2.49e-01	8.17e-02	1.53e-01
Apoptotic cleavage of cellular proteins	35	1.04e-02	4.89e-02	0.39200	-0.290000	-2.63e-01	2.95e-03	6.98e-03
Inositol phosphate metabolism	45	3.00e-03	1.84e-02	0.39200	-0.286000	-2.68e-01	8.95e-04	1.88e-03
Caspase activation via Death Receptors in the presence of ligand	16	4.15e-02	1.39e-01	0.39100	0.193000	3.40e-01	1.82e-01	1.84e-02
RHOH GTPase cycle	36	7.56e-03	3.86e-02	0.39100	-0.250000	-3.00e-01	9.30e-03	1.81e-03
RIPK1-mediated regulated necrosis	27	2.87e-02	1.08e-01	0.38900	0.294000	2.55e-01	8.12e-03	2.18e-02
Regulation of necroptotic cell death	27	2.87e-02	1.08e-01	0.38900	0.294000	2.55e-01	8.12e-03	2.18e-02
Regulation of expression of SLITs and ROBOs	159	2.64e-10	1.32e-08	0.38900	0.305000	2.42e-01	3.10e-11	1.43e-07
PKA-mediated phosphorylation of CREB	19	4.92e-02	1.56e-01	0.38900	-0.320000	-2.20e-01	1.57e-02	9.63e-02
Prednisone ADME	10	2.79e-01	4.62e-01	0.38900	-0.263000	-2.86e-01	1.50e-01	1.17e-01
Regulation of localization of FOXO transcription factors	11	1.45e-02	6.39e-02	0.38800	-0.376000	-9.45e-02	3.07e-02	5.87e-01
rRNA processing	186	5.25e-13	5.97e-11	0.38600	0.316000	2.22e-01	1.08e-13	1.77e-07
Diseases associated with O-glycosylation of proteins	66	2.34e-05	3.70e-04	0.38500	-0.321000	-2.13e-01	6.43e-06	2.70e-03
SLBP independent Processing of Histone Pre-mRNAs	10	6.96e-03	3.60e-02	0.38500	-0.044800	-3.82e-01	8.06e-01	3.62e-02
APC/C:Cdc20 mediated degradation of mitotic proteins	74	1.01e-04	1.08e-03	0.38500	0.280000	2.64e-01	3.04e-05	8.58e-05
SHC1 events in ERBB4 signaling	14	1.77e-01	3.60e-01	0.38500	-0.273000	-2.71e-01	7.67e-02	7.92e-02
Mitotic Telophase/Cytokinesis	10	1.69e-01	3.52e-01	0.38400	-0.199000	-3.28e-01	2.77e-01	7.21e-02
CDK-mediated phosphorylation and removal of Cdc6	71	1.81e-04	1.73e-03	0.38200	0.272000	2.68e-01	7.26e-05	9.64e-05
Deadenylation of mRNA	25	1.32e-02	5.93e-02	0.38100	-0.198000	-3.25e-01	8.60e-02	4.92e-03
G1/S DNA Damage Checkpoints	66	3.40e-04	3.02e-03	0.38000	0.275000	2.63e-01	1.11e-04	2.22e-04
Adenylate cyclase inhibitory pathway	14	1.75e-01	3.59e-01	0.37900	-0.286000	-2.48e-01	6.39e-02	1.08e-01
Signal amplification	33	1.80e-02	7.50e-02	0.37800	-0.281000	-2.52e-01	5.13e-03	1.23e-02
RND1 GTPase cycle	41	7.56e-03	3.86e-02	0.37700	-0.272000	-2.62e-01	2.56e-03	3.75e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	1.16e-04	1.22e-03	0.37700	0.280000	2.53e-01	2.81e-05	1.48e-04
N-glycan antennae elongation in the medial/trans-Golgi	26	1.72e-02	7.29e-02	0.37700	-0.315000	-2.07e-01	5.46e-03	6.72e-02
Bicarbonate transporters	10	9.98e-02	2.53e-01	0.37500	-0.341000	-1.55e-01	6.17e-02	3.96e-01
GRB2 events in EGFR signaling	13	1.85e-01	3.70e-01	0.37400	-0.294000	-2.31e-01	6.62e-02	1.50e-01
NIK–>noncanonical NF-kB signaling	57	1.23e-03	8.64e-03	0.37400	0.274000	2.55e-01	3.52e-04	8.76e-04
Collagen biosynthesis and modifying enzymes	65	8.68e-07	2.40e-05	0.37400	-0.336000	-1.63e-01	2.72e-06	2.33e-02
Gastrulation	21	7.89e-02	2.19e-01	0.37300	-0.282000	-2.43e-01	2.50e-02	5.37e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	3.30e-03	1.98e-02	0.37300	-0.067600	-3.67e-01	6.62e-01	1.76e-02
Other semaphorin interactions	18	1.72e-03	1.17e-02	0.37200	-0.361000	-9.11e-02	8.01e-03	5.03e-01
NRAGE signals death through JNK	53	1.61e-05	2.94e-04	0.37200	-0.334000	-1.65e-01	2.65e-05	3.77e-02
FCERI mediated MAPK activation	29	2.31e-02	9.23e-02	0.37100	-0.294000	-2.27e-01	6.10e-03	3.46e-02
PKA activation in glucagon signalling	17	2.58e-02	1.00e-01	0.37000	-0.335000	-1.59e-01	1.69e-02	2.56e-01
Insulin processing	26	4.41e-02	1.45e-01	0.37000	-0.240000	-2.82e-01	3.39e-02	1.29e-02
Pyrimidine catabolism	12	2.38e-01	4.25e-01	0.37000	-0.281000	-2.41e-01	9.20e-02	1.48e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	10	2.55e-01	4.40e-01	0.36900	-0.299000	-2.16e-01	1.01e-01	2.37e-01
Influenza Viral RNA Transcription and Replication	129	3.06e-08	1.15e-06	0.36900	0.298000	2.18e-01	4.98e-09	1.93e-05
Dectin-1 mediated noncanonical NF-kB signaling	60	9.91e-04	7.37e-03	0.36900	0.273000	2.48e-01	2.56e-04	8.84e-04
O-linked glycosylation of mucins	62	5.77e-06	1.31e-04	0.36800	-0.327000	-1.68e-01	8.50e-06	2.18e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	62	9.89e-04	7.37e-03	0.36600	0.258000	2.60e-01	4.39e-04	4.07e-04
Nucleotide-like (purinergic) receptors	13	1.37e-02	6.08e-02	0.36600	-0.353000	-9.49e-02	2.74e-02	5.54e-01
DAG and IP3 signaling	39	4.60e-05	5.88e-04	0.36600	-0.341000	-1.31e-01	2.24e-04	1.57e-01
RND2 GTPase cycle	42	6.89e-03	3.58e-02	0.36500	-0.281000	-2.34e-01	1.63e-03	8.78e-03
Energy dependent regulation of mTOR by LKB1-AMPK	28	4.48e-02	1.46e-01	0.36500	-0.256000	-2.60e-01	1.91e-02	1.73e-02
Pre-NOTCH Processing in Golgi	18	1.81e-02	7.52e-02	0.36300	-0.332000	-1.46e-01	1.48e-02	2.84e-01
Adenylate cyclase activating pathway	10	2.08e-01	3.90e-01	0.36200	-0.309000	-1.89e-01	9.04e-02	3.01e-01
ATF4 activates genes in response to endoplasmic reticulum stress	28	1.54e-02	6.74e-02	0.35900	0.304000	1.91e-01	5.37e-03	8.00e-02
CTNNB1 S33 mutants aren’t phosphorylated	14	2.05e-01	3.86e-01	0.35900	-0.274000	-2.32e-01	7.58e-02	1.33e-01
CTNNB1 S37 mutants aren’t phosphorylated	14	2.05e-01	3.86e-01	0.35900	-0.274000	-2.32e-01	7.58e-02	1.33e-01
CTNNB1 S45 mutants aren’t phosphorylated	14	2.05e-01	3.86e-01	0.35900	-0.274000	-2.32e-01	7.58e-02	1.33e-01
CTNNB1 T41 mutants aren’t phosphorylated	14	2.05e-01	3.86e-01	0.35900	-0.274000	-2.32e-01	7.58e-02	1.33e-01
Signaling by CTNNB1 phospho-site mutants	14	2.05e-01	3.86e-01	0.35900	-0.274000	-2.32e-01	7.58e-02	1.33e-01
Signaling by GSK3beta mutants	14	2.05e-01	3.86e-01	0.35900	-0.274000	-2.32e-01	7.58e-02	1.33e-01
p75NTR recruits signalling complexes	12	2.72e-01	4.54e-01	0.35800	0.243000	2.64e-01	1.45e-01	1.14e-01
Miscellaneous substrates	12	2.68e-01	4.53e-01	0.35800	0.239000	2.67e-01	1.51e-01	1.10e-01
Signaling by FLT3 fusion proteins	19	5.25e-02	1.63e-01	0.35800	-0.306000	-1.85e-01	2.08e-02	1.64e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15	1.20e-01	2.82e-01	0.35700	-0.299000	-1.96e-01	4.50e-02	1.88e-01
Synthesis of IP3 and IP4 in the cytosol	25	4.37e-02	1.44e-01	0.35700	-0.288000	-2.12e-01	1.28e-02	6.64e-02
Glutamate and glutamine metabolism	12	2.78e-02	1.05e-01	0.35700	-0.100000	-3.43e-01	5.49e-01	3.99e-02
Asymmetric localization of PCP proteins	62	1.40e-03	9.69e-03	0.35700	0.255000	2.50e-01	5.26e-04	6.67e-04
Metabolism of nitric oxide: NOS3 activation and regulation	15	1.48e-01	3.28e-01	0.35700	-0.289000	-2.09e-01	5.25e-02	1.62e-01
NF-kB is activated and signals survival	12	2.34e-01	4.20e-01	0.35600	0.284000	2.15e-01	8.89e-02	1.96e-01
Folding of actin by CCT/TriC	10	2.17e-01	4.01e-01	0.35600	0.305000	1.85e-01	9.54e-02	3.12e-01
Removal of the Flap Intermediate from the C-strand	17	4.13e-02	1.39e-01	0.35500	-0.159000	-3.18e-01	2.56e-01	2.33e-02
TNFR2 non-canonical NF-kB pathway	94	4.06e-05	5.42e-04	0.35500	0.237000	2.65e-01	7.23e-05	9.00e-06
GRB2 events in ERBB2 signaling	16	1.86e-01	3.70e-01	0.35500	-0.248000	-2.54e-01	8.52e-02	7.90e-02
Ephrin signaling	17	2.14e-03	1.41e-02	0.35500	-0.348000	-6.80e-02	1.29e-02	6.27e-01
Regulation of signaling by NODAL	10	3.47e-01	5.20e-01	0.35300	0.238000	2.61e-01	1.92e-01	1.53e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	43	6.50e-04	5.05e-03	0.35300	-0.311000	-1.67e-01	4.25e-04	5.75e-02
PERK regulates gene expression	32	8.41e-03	4.20e-02	0.35200	0.301000	1.83e-01	3.19e-03	7.37e-02
Kinesins	42	9.84e-03	4.68e-02	0.35200	-0.271000	-2.25e-01	2.41e-03	1.15e-02
PKA activation	18	9.34e-02	2.43e-01	0.35100	-0.291000	-1.97e-01	3.27e-02	1.49e-01
Gastrin-CREB signalling pathway via PKC and MAPK	17	1.69e-01	3.52e-01	0.35100	-0.260000	-2.35e-01	6.36e-02	9.29e-02
eNOS activation	11	3.13e-01	4.91e-01	0.35000	-0.263000	-2.31e-01	1.31e-01	1.85e-01
Signal regulatory protein family interactions	13	1.24e-01	2.87e-01	0.35000	-0.305000	-1.71e-01	5.69e-02	2.86e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	5.60e-03	3.02e-02	0.34900	-0.246000	-2.48e-01	2.34e-03	2.21e-03
p75NTR signals via NF-kB	15	2.00e-01	3.86e-01	0.34900	0.267000	2.25e-01	7.38e-02	1.32e-01
Paracetamol ADME	27	2.01e-02	8.22e-02	0.34800	-0.297000	-1.82e-01	7.52e-03	1.02e-01
Regulation of KIT signaling	16	1.41e-01	3.15e-01	0.34600	-0.283000	-1.99e-01	5.03e-02	1.68e-01
O-linked glycosylation	107	5.97e-07	1.74e-05	0.34500	-0.290000	-1.87e-01	2.10e-07	8.33e-04
RND3 GTPase cycle	41	1.59e-02	6.83e-02	0.34500	-0.256000	-2.31e-01	4.59e-03	1.04e-02
RHOG GTPase cycle	69	1.83e-04	1.73e-03	0.34500	-0.284000	-1.95e-01	4.46e-05	5.01e-03
Post NMDA receptor activation events	58	9.32e-04	7.00e-03	0.34500	-0.281000	-2.00e-01	2.16e-04	8.46e-03
ADP signalling through P2Y purinoceptor 1	25	6.19e-02	1.85e-01	0.34500	-0.272000	-2.11e-01	1.84e-02	6.77e-02
Sphingolipid de novo biosynthesis	41	1.58e-02	6.83e-02	0.34400	-0.256000	-2.30e-01	4.49e-03	1.08e-02
GABA receptor activation	57	3.41e-03	2.03e-02	0.34400	-0.251000	-2.35e-01	1.02e-03	2.11e-03
RAC1 GTPase cycle	170	5.41e-13	5.97e-11	0.34400	-0.305000	-1.60e-01	6.83e-12	3.05e-04
SHC1 events in EGFR signaling	14	1.87e-01	3.71e-01	0.34400	-0.280000	-2.00e-01	6.96e-02	1.94e-01
CS/DS degradation	12	1.70e-01	3.53e-01	0.34400	-0.297000	-1.75e-01	7.51e-02	2.95e-01
Ca-dependent events	35	1.08e-03	7.96e-03	0.34400	-0.313000	-1.41e-01	1.33e-03	1.48e-01
Nuclear Receptor transcription pathway	51	4.94e-03	2.75e-02	0.34300	-0.263000	-2.20e-01	1.15e-03	6.46e-03
NR1H2 and NR1H3-mediated signaling	53	1.68e-04	1.65e-03	0.34300	-0.303000	-1.61e-01	1.35e-04	4.27e-02
Transcriptional Regulation by E2F6	32	3.92e-02	1.35e-01	0.34300	-0.227000	-2.57e-01	2.66e-02	1.17e-02
RHOF GTPase cycle	40	1.04e-02	4.89e-02	0.34100	-0.275000	-2.02e-01	2.63e-03	2.69e-02
cGMP effects	15	1.00e-01	2.53e-01	0.34100	-0.298000	-1.66e-01	4.59e-02	2.65e-01
Apoptotic execution phase	43	1.52e-02	6.66e-02	0.34100	-0.247000	-2.35e-01	5.02e-03	7.71e-03
Collagen degradation	39	3.50e-03	2.08e-02	0.34100	-0.294000	-1.72e-01	1.49e-03	6.23e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	1.92e-01	3.75e-01	0.34100	-0.290000	-1.78e-01	8.17e-02	2.84e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	12	2.84e-01	4.69e-01	0.34000	-0.264000	-2.14e-01	1.13e-01	2.00e-01
Activation of BH3-only proteins	30	1.83e-02	7.58e-02	0.33900	-0.287000	-1.80e-01	6.45e-03	8.75e-02
Receptor Mediated Mitophagy	10	2.86e-01	4.70e-01	0.33900	-0.188000	-2.82e-01	3.04e-01	1.22e-01
Glucagon signaling in metabolic regulation	33	8.99e-03	4.38e-02	0.33900	-0.292000	-1.72e-01	3.71e-03	8.78e-02
Synthesis of PC	27	6.95e-02	2.01e-01	0.33800	-0.222000	-2.55e-01	4.58e-02	2.19e-02
Synthesis of bile acids and bile salts	34	3.90e-02	1.34e-01	0.33700	-0.245000	-2.32e-01	1.35e-02	1.91e-02
Transcriptional regulation of pluripotent stem cells	30	3.01e-02	1.12e-01	0.33700	-0.276000	-1.94e-01	8.90e-03	6.61e-02
Hedgehog ligand biogenesis	63	2.56e-03	1.63e-02	0.33700	0.241000	2.35e-01	9.24e-04	1.23e-03
p38MAPK events	13	2.91e-01	4.77e-01	0.33700	-0.240000	-2.37e-01	1.34e-01	1.39e-01
Maturation of spike protein 9694548	35	2.46e-02	9.71e-02	0.33600	-0.266000	-2.06e-01	6.52e-03	3.46e-02
APC/C:Cdc20 mediated degradation of Cyclin B	24	9.11e-02	2.39e-01	0.33600	0.257000	2.16e-01	2.90e-02	6.68e-02
Defective B4GALT7 causes EDS, progeroid type	17	9.00e-02	2.37e-01	0.33600	-0.290000	-1.69e-01	3.84e-02	2.27e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	25	3.70e-02	1.29e-01	0.33500	-0.285000	-1.77e-01	1.37e-02	1.26e-01
Regulation of TP53 Activity through Acetylation	29	4.79e-02	1.53e-01	0.33400	-0.264000	-2.05e-01	1.38e-02	5.63e-02
Protein-protein interactions at synapses	78	5.47e-05	6.66e-04	0.33300	-0.281000	-1.79e-01	1.82e-05	6.22e-03
Germ layer formation at gastrulation	16	1.77e-01	3.60e-01	0.33200	-0.267000	-1.97e-01	6.40e-02	1.72e-01
Elastic fibre formation	40	2.60e-03	1.64e-02	0.33200	-0.291000	-1.59e-01	1.43e-03	8.09e-02
Regulation of APC/C activators between G1/S and early anaphase	79	5.65e-04	4.55e-03	0.33200	0.249000	2.19e-01	1.26e-04	7.76e-04
Sensory processing of sound by outer hair cells of the cochlea	49	3.74e-04	3.27e-03	0.33200	-0.296000	-1.50e-01	3.41e-04	6.94e-02
Defective B3GALTL causes PpS	36	3.02e-02	1.12e-01	0.33100	-0.254000	-2.12e-01	8.27e-03	2.74e-02
Collagen formation	88	7.48e-08	2.57e-06	0.33100	-0.304000	-1.33e-01	8.45e-07	3.12e-02
APC truncation mutants have impaired AXIN binding	13	3.04e-01	4.84e-01	0.33100	-0.236000	-2.33e-01	1.41e-01	1.46e-01
AXIN missense mutants destabilize the destruction complex	13	3.04e-01	4.84e-01	0.33100	-0.236000	-2.33e-01	1.41e-01	1.46e-01
Signaling by AMER1 mutants	13	3.04e-01	4.84e-01	0.33100	-0.236000	-2.33e-01	1.41e-01	1.46e-01
Signaling by APC mutants	13	3.04e-01	4.84e-01	0.33100	-0.236000	-2.33e-01	1.41e-01	1.46e-01
Signaling by AXIN mutants	13	3.04e-01	4.84e-01	0.33100	-0.236000	-2.33e-01	1.41e-01	1.46e-01
Truncations of AMER1 destabilize the destruction complex	13	3.04e-01	4.84e-01	0.33100	-0.236000	-2.33e-01	1.41e-01	1.46e-01
G alpha (12/13) signalling events	74	7.48e-06	1.61e-04	0.33100	-0.295000	-1.50e-01	1.14e-05	2.54e-02
Regulation of MECP2 expression and activity	30	3.69e-03	2.16e-02	0.33100	-0.303000	-1.32e-01	4.04e-03	2.09e-01
Collagen chain trimerization	42	2.08e-05	3.45e-04	0.33100	-0.318000	-9.27e-02	3.66e-04	2.99e-01
Suppression of phagosomal maturation	13	3.06e-01	4.84e-01	0.33000	0.239000	2.27e-01	1.36e-01	1.56e-01
Glycogen breakdown (glycogenolysis)	11	3.55e-01	5.25e-01	0.32900	-0.214000	-2.49e-01	2.19e-01	1.52e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	2.24e-01	4.10e-01	0.32800	0.215000	2.48e-01	1.36e-01	8.57e-02
Attachment and Entry 9694614	16	1.42e-01	3.18e-01	0.32800	-0.276000	-1.77e-01	5.58e-02	2.20e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	87	3.95e-04	3.41e-03	0.32700	0.223000	2.39e-01	3.15e-04	1.12e-04
Sema3A PAK dependent Axon repulsion	14	3.06e-02	1.13e-01	0.32700	-0.314000	-9.29e-02	4.20e-02	5.47e-01
Opioid Signalling	88	1.08e-05	2.11e-04	0.32700	-0.281000	-1.69e-01	5.35e-06	6.23e-03
Regulation of PTEN mRNA translation	25	1.04e-01	2.59e-01	0.32700	-0.241000	-2.21e-01	3.69e-02	5.58e-02
Erythrocytes take up carbon dioxide and release oxygen	12	3.22e-01	5.01e-01	0.32600	-0.250000	-2.09e-01	1.33e-01	2.09e-01
O2/CO2 exchange in erythrocytes	12	3.22e-01	5.01e-01	0.32600	-0.250000	-2.09e-01	1.33e-01	2.09e-01
Golgi Associated Vesicle Biogenesis	51	1.07e-02	4.99e-02	0.32600	-0.236000	-2.25e-01	3.55e-03	5.45e-03
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15	1.85e-01	3.70e-01	0.32500	-0.269000	-1.83e-01	7.15e-02	2.20e-01
Influenza Infection	148	1.02e-07	3.44e-06	0.32200	0.266000	1.83e-01	2.37e-08	1.25e-04
Synthesis of IP2, IP, and Ins in the cytosol	13	1.62e-01	3.43e-01	0.32200	-0.282000	-1.54e-01	7.78e-02	3.35e-01
Signaling by cytosolic FGFR1 fusion mutants	17	1.56e-02	6.76e-02	0.32200	-0.309000	-8.91e-02	2.73e-02	5.25e-01
APC/C-mediated degradation of cell cycle proteins	86	5.46e-04	4.44e-03	0.32100	0.238000	2.16e-01	1.38e-04	5.30e-04
Regulation of mitotic cell cycle	86	5.46e-04	4.44e-03	0.32100	0.238000	2.16e-01	1.38e-04	5.30e-04
PKMTs methylate histone lysines	37	7.13e-03	3.68e-02	0.32100	-0.279000	-1.59e-01	3.28e-03	9.52e-02
Heparan sulfate/heparin (HS-GAG) metabolism	49	6.44e-03	3.39e-02	0.32100	-0.260000	-1.87e-01	1.62e-03	2.31e-02
CaM pathway	33	1.45e-03	9.93e-03	0.32000	-0.300000	-1.14e-01	2.90e-03	2.57e-01
Calmodulin induced events	33	1.45e-03	9.93e-03	0.32000	-0.300000	-1.14e-01	2.90e-03	2.57e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	10	2.27e-01	4.13e-01	0.32000	0.146000	2.85e-01	4.23e-01	1.19e-01
Cytosolic sulfonation of small molecules	21	1.68e-01	3.52e-01	0.31900	-0.226000	-2.25e-01	7.26e-02	7.44e-02
ER-Phagosome pathway	87	2.18e-04	2.03e-03	0.31900	0.193000	2.54e-01	1.88e-03	4.17e-05
Activation of NMDA receptors and postsynaptic events	69	1.34e-03	9.30e-03	0.31900	-0.253000	-1.94e-01	2.79e-04	5.27e-03
A tetrasaccharide linker sequence is required for GAG synthesis	23	3.19e-02	1.16e-01	0.31900	-0.285000	-1.43e-01	1.81e-02	2.34e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	20	1.27e-01	2.93e-01	0.31700	-0.259000	-1.82e-01	4.45e-02	1.58e-01
Translation	262	1.84e-13	2.59e-11	0.31600	0.266000	1.71e-01	1.14e-13	1.80e-06
Plasma lipoprotein assembly	19	1.90e-01	3.74e-01	0.31600	-0.204000	-2.41e-01	1.23e-01	6.92e-02
Depolymerisation of the Nuclear Lamina	14	2.94e-01	4.77e-01	0.31500	-0.203000	-2.41e-01	1.89e-01	1.18e-01
Interleukin-10 signaling	45	1.87e-02	7.69e-02	0.31500	0.201000	2.43e-01	1.99e-02	4.82e-03
Defects in cobalamin (B12) metabolism	12	6.73e-02	1.96e-01	0.31500	-0.092400	-3.01e-01	5.79e-01	7.10e-02
MASTL Facilitates Mitotic Progression	10	3.65e-01	5.32e-01	0.31500	-0.182000	-2.57e-01	3.19e-01	1.60e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	1.37e-01	3.10e-01	0.31400	-0.287000	-1.28e-01	8.49e-02	4.43e-01
Defective EXT2 causes exostoses 2	12	1.37e-01	3.10e-01	0.31400	-0.287000	-1.28e-01	8.49e-02	4.43e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	38	1.20e-04	1.25e-03	0.31400	-0.303000	-8.49e-02	1.24e-03	3.65e-01
HS-GAG biosynthesis	28	7.81e-02	2.18e-01	0.31400	-0.247000	-1.95e-01	2.39e-02	7.40e-02
Platelet calcium homeostasis	27	1.42e-02	6.31e-02	0.31400	-0.285000	-1.33e-01	1.05e-02	2.32e-01
Dermatan sulfate biosynthesis	10	4.33e-01	5.87e-01	0.31400	-0.233000	-2.10e-01	2.03e-01	2.49e-01
Extracellular matrix organization	287	1.23e-15	3.80e-13	0.31300	-0.269000	-1.60e-01	3.93e-15	3.04e-06
RHO GTPases Activate NADPH Oxidases	22	6.02e-02	1.81e-01	0.31300	-0.273000	-1.54e-01	2.69e-02	2.12e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	1.87e-01	3.71e-01	0.31200	-0.287000	-1.24e-01	1.17e-01	4.96e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	1.19e-02	5.45e-02	0.31200	-0.041100	-3.09e-01	7.90e-01	4.50e-02
ADORA2B mediated anti-inflammatory cytokines production	42	8.58e-03	4.24e-02	0.31200	-0.264000	-1.65e-01	3.02e-03	6.42e-02
Factors involved in megakaryocyte development and platelet production	128	2.57e-05	3.94e-04	0.31200	-0.232000	-2.08e-01	5.71e-06	4.80e-05
TNFs bind their physiological receptors	25	5.25e-02	1.63e-01	0.31100	0.160000	2.67e-01	1.67e-01	2.10e-02
Antigen processing-Cross presentation	100	9.89e-05	1.06e-03	0.31000	0.186000	2.48e-01	1.29e-03	1.85e-05
O-glycosylation of TSR domain-containing proteins	37	4.02e-02	1.36e-01	0.31000	-0.241000	-1.95e-01	1.12e-02	4.00e-02
CD28 co-stimulation	32	9.38e-03	4.53e-02	0.30900	-0.278000	-1.36e-01	6.48e-03	1.83e-01
CDC42 GTPase cycle	143	7.13e-11	4.08e-09	0.30900	-0.284000	-1.23e-01	4.54e-09	1.09e-02
Regulation of NPAS4 gene expression	13	4.78e-02	1.53e-01	0.30900	-0.298000	-8.09e-02	6.27e-02	6.14e-01
Integrin cell surface interactions	66	6.21e-04	4.85e-03	0.30900	-0.262000	-1.63e-01	2.26e-04	2.24e-02
Long-term potentiation	22	1.60e-01	3.40e-01	0.30900	-0.235000	-2.00e-01	5.64e-02	1.04e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	15	8.10e-02	2.22e-01	0.30700	-0.283000	-1.18e-01	5.77e-02	4.29e-01
Ras activation upon Ca2+ influx through NMDA receptor	19	1.94e-01	3.78e-01	0.30400	-0.240000	-1.87e-01	7.01e-02	1.58e-01
Downstream TCR signaling	92	8.11e-04	6.18e-03	0.30400	0.210000	2.20e-01	4.86e-04	2.65e-04
EPH-ephrin mediated repulsion of cells	48	2.12e-02	8.56e-02	0.30400	-0.230000	-1.98e-01	5.77e-03	1.75e-02
RAC3 GTPase cycle	84	3.12e-04	2.80e-03	0.30400	-0.250000	-1.73e-01	7.53e-05	6.18e-03
Activation of NF-kappaB in B cells	64	6.03e-03	3.19e-02	0.30300	0.230000	1.97e-01	1.47e-03	6.34e-03
Mismatch Repair	15	5.45e-03	2.97e-02	0.30200	-0.013900	-3.02e-01	9.26e-01	4.29e-02
Cell-Cell communication	112	5.29e-07	1.57e-05	0.30200	-0.267000	-1.39e-01	9.96e-07	1.08e-02
Signaling by PDGFRA extracellular domain mutants	12	3.07e-01	4.84e-01	0.30100	-0.251000	-1.67e-01	1.33e-01	3.16e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	3.07e-01	4.84e-01	0.30100	-0.251000	-1.67e-01	1.33e-01	3.16e-01
Repression of WNT target genes	13	6.99e-02	2.01e-01	0.30100	-0.288000	-8.92e-02	7.24e-02	5.77e-01
Pausing and recovery of Tat-mediated HIV elongation	27	1.30e-01	2.96e-01	0.30100	0.211000	2.14e-01	5.72e-02	5.40e-02
Tat-mediated HIV elongation arrest and recovery	27	1.30e-01	2.96e-01	0.30100	0.211000	2.14e-01	5.72e-02	5.40e-02
Role of phospholipids in phagocytosis	23	1.56e-02	6.76e-02	0.30100	-0.283000	-1.03e-01	1.89e-02	3.92e-01
Signalling to RAS	20	1.75e-01	3.59e-01	0.30100	-0.241000	-1.81e-01	6.25e-02	1.62e-01
Glycosaminoglycan metabolism	116	3.03e-05	4.41e-04	0.30100	-0.243000	-1.77e-01	5.88e-06	1.01e-03
Circadian Clock	69	1.17e-03	8.36e-03	0.30000	-0.250000	-1.67e-01	3.28e-04	1.67e-02
Phospholipid metabolism	192	5.36e-08	1.93e-06	0.30000	-0.241000	-1.79e-01	8.19e-09	1.82e-05
L1CAM interactions	92	4.15e-04	3.55e-03	0.30000	-0.238000	-1.83e-01	8.07e-05	2.44e-03
N-Glycan antennae elongation	15	3.06e-01	4.84e-01	0.30000	-0.229000	-1.94e-01	1.25e-01	1.94e-01
Organic cation transport	10	1.62e-01	3.44e-01	0.29900	-0.282000	-1.01e-01	1.23e-01	5.80e-01
Signaling by BRAF and RAF1 fusions	60	1.14e-03	8.17e-03	0.29900	-0.259000	-1.51e-01	5.22e-04	4.37e-02
trans-Golgi Network Vesicle Budding	67	6.72e-03	3.51e-02	0.29900	-0.213000	-2.11e-01	2.60e-03	2.85e-03
Cellular response to hypoxia	71	5.04e-03	2.79e-02	0.29900	0.213000	2.10e-01	1.88e-03	2.25e-03
Orc1 removal from chromatin	69	5.50e-03	2.98e-02	0.29900	0.220000	2.03e-01	1.58e-03	3.60e-03
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27	8.17e-02	2.23e-01	0.29900	-0.245000	-1.71e-01	2.73e-02	1.25e-01
HDR through MMEJ (alt-NHEJ)	11	7.04e-02	2.02e-01	0.29900	-0.065400	-2.91e-01	7.07e-01	9.43e-02
Cell-cell junction organization	56	1.32e-03	9.25e-03	0.29800	-0.261000	-1.44e-01	7.31e-04	6.15e-02
ECM proteoglycans	55	4.90e-04	4.05e-03	0.29800	-0.269000	-1.28e-01	5.61e-04	1.00e-01
RHO GTPase cycle	420	2.23e-18	1.72e-15	0.29800	-0.249000	-1.63e-01	1.72e-18	9.76e-09
Rap1 signalling	16	3.07e-01	4.84e-01	0.29800	-0.210000	-2.11e-01	1.46e-01	1.45e-01
G-protein beta:gamma signalling	30	1.45e-02	6.39e-02	0.29700	-0.269000	-1.26e-01	1.06e-02	2.33e-01
FCERI mediated Ca+2 mobilization	27	1.07e-02	4.99e-02	0.29700	-0.277000	-1.07e-01	1.28e-02	3.38e-01
Response of Mtb to phagocytosis	22	1.36e-01	3.08e-01	0.29600	0.170000	2.43e-01	1.69e-01	4.87e-02
GAB1 signalosome	17	2.64e-01	4.48e-01	0.29600	-0.228000	-1.88e-01	1.03e-01	1.79e-01
Infection with Mycobacterium tuberculosis	25	1.10e-01	2.68e-01	0.29600	0.172000	2.40e-01	1.37e-01	3.74e-02
HIV elongation arrest and recovery	29	1.16e-01	2.75e-01	0.29500	0.220000	1.97e-01	4.04e-02	6.67e-02
Pausing and recovery of HIV elongation	29	1.16e-01	2.75e-01	0.29500	0.220000	1.97e-01	4.04e-02	6.67e-02
Signaling by MET	66	2.77e-03	1.71e-02	0.29500	-0.241000	-1.70e-01	6.97e-04	1.72e-02
Ca2+ pathway	62	1.80e-04	1.73e-03	0.29400	-0.267000	-1.24e-01	2.74e-04	9.12e-02
Signaling by NOTCH4	79	3.32e-03	1.98e-02	0.29400	0.205000	2.11e-01	1.59e-03	1.18e-03
Signaling by SCF-KIT	43	3.66e-02	1.28e-01	0.29400	-0.226000	-1.88e-01	1.02e-02	3.32e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	2.82e-02	1.07e-01	0.29400	-0.291000	-4.21e-02	6.94e-02	7.93e-01
mRNA decay by 3’ to 5’ exoribonuclease	16	2.88e-01	4.73e-01	0.29400	0.228000	1.85e-01	1.15e-01	1.99e-01
Molecules associated with elastic fibres	29	7.91e-02	2.19e-01	0.29300	-0.239000	-1.70e-01	2.58e-02	1.14e-01
Activation of AMPK downstream of NMDARs	10	4.23e-01	5.80e-01	0.29300	-0.171000	-2.38e-01	3.48e-01	1.93e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	68	2.57e-03	1.64e-02	0.29300	0.169000	2.39e-01	1.61e-02	6.39e-04
MTOR signalling	40	5.14e-02	1.60e-01	0.29300	-0.221000	-1.92e-01	1.56e-02	3.54e-02
Uptake and actions of bacterial toxins	29	6.50e-02	1.92e-01	0.29200	-0.160000	-2.44e-01	1.35e-01	2.28e-02
CLEC7A (Dectin-1) induces NFAT activation	11	9.45e-02	2.44e-01	0.29200	-0.283000	-7.31e-02	1.05e-01	6.74e-01
Disorders of Developmental Biology	11	3.38e-01	5.11e-01	0.29000	-0.246000	-1.53e-01	1.57e-01	3.78e-01
Disorders of Nervous System Development	11	3.38e-01	5.11e-01	0.29000	-0.246000	-1.53e-01	1.57e-01	3.78e-01
Loss of function of MECP2 in Rett syndrome	11	3.38e-01	5.11e-01	0.29000	-0.246000	-1.53e-01	1.57e-01	3.78e-01
Pervasive developmental disorders	11	3.38e-01	5.11e-01	0.29000	-0.246000	-1.53e-01	1.57e-01	3.78e-01
Thromboxane signalling through TP receptor	24	1.56e-01	3.36e-01	0.29000	-0.227000	-1.80e-01	5.39e-02	1.26e-01
RHO GTPases activate PAKs	19	1.43e-01	3.19e-01	0.29000	-0.249000	-1.50e-01	6.06e-02	2.59e-01
Regulation of BACH1 activity	15	2.53e-01	4.38e-01	0.29000	0.160000	2.41e-01	2.84e-01	1.05e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21	4.63e-02	1.50e-01	0.29000	0.113000	2.66e-01	3.68e-01	3.46e-02
UCH proteinases	81	3.06e-03	1.87e-02	0.28900	0.216000	1.92e-01	7.74e-04	2.74e-03
Activation of BAD and translocation to mitochondria	15	2.41e-01	4.28e-01	0.28900	-0.243000	-1.56e-01	1.02e-01	2.95e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	17	1.46e-01	3.24e-01	0.28900	-0.254000	-1.38e-01	6.99e-02	3.23e-01
NRIF signals cell death from the nucleus	16	2.53e-01	4.38e-01	0.28900	0.237000	1.66e-01	1.01e-01	2.52e-01
ERBB2 Regulates Cell Motility	15	3.49e-01	5.23e-01	0.28900	-0.211000	-1.97e-01	1.57e-01	1.87e-01
RAS processing	19	4.06e-02	1.37e-01	0.28800	-0.096800	-2.71e-01	4.65e-01	4.07e-02
GPER1 signaling	44	4.68e-03	2.64e-02	0.28800	-0.257000	-1.30e-01	3.18e-03	1.36e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	3.54e-01	5.25e-01	0.28800	-0.163000	-2.37e-01	3.27e-01	1.56e-01
alpha-linolenic acid (ALA) metabolism	12	3.54e-01	5.25e-01	0.28800	-0.163000	-2.37e-01	3.27e-01	1.56e-01
PI3K events in ERBB4 signaling	10	3.91e-01	5.52e-01	0.28700	-0.155000	-2.42e-01	3.96e-01	1.85e-01
Chylomicron assembly	10	2.37e-01	4.24e-01	0.28700	-0.113000	-2.64e-01	5.37e-01	1.48e-01
Defective B3GAT3 causes JDSSDHD	17	1.65e-01	3.48e-01	0.28700	-0.249000	-1.43e-01	7.52e-02	3.08e-01
Regulation of signaling by CBL	18	2.63e-01	4.48e-01	0.28700	-0.182000	-2.22e-01	1.82e-01	1.02e-01
Chondroitin sulfate/dermatan sulfate metabolism	45	9.80e-03	4.68e-02	0.28700	-0.247000	-1.45e-01	4.06e-03	9.18e-02
Sensory processing of sound	69	5.63e-05	6.74e-04	0.28700	-0.263000	-1.14e-01	1.53e-04	1.02e-01
RHOD GTPase cycle	48	3.69e-02	1.28e-01	0.28700	-0.208000	-1.98e-01	1.28e-02	1.78e-02
Platelet sensitization by LDL	17	2.86e-01	4.71e-01	0.28600	-0.221000	-1.81e-01	1.14e-01	1.97e-01
Alpha-protein kinase 1 signaling pathway	10	4.14e-01	5.72e-01	0.28500	0.158000	2.37e-01	3.86e-01	1.94e-01
Mitochondrial translation initiation	87	2.65e-05	4.02e-04	0.28500	0.255000	1.27e-01	3.91e-05	4.09e-02
Mitochondrial translation	93	1.90e-05	3.33e-04	0.28500	0.253000	1.30e-01	2.41e-05	3.01e-02
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24	1.07e-01	2.62e-01	0.28400	-0.241000	-1.52e-01	4.14e-02	1.98e-01
Mitochondrial translation termination	87	1.98e-05	3.40e-04	0.28400	0.256000	1.23e-01	3.68e-05	4.69e-02
Signaling by Non-Receptor Tyrosine Kinases	55	2.34e-02	9.31e-02	0.28400	-0.210000	-1.91e-01	7.08e-03	1.42e-02
Signaling by PTK6	55	2.34e-02	9.31e-02	0.28400	-0.210000	-1.91e-01	7.08e-03	1.42e-02
Signaling by NTRK3 (TRKC)	17	3.19e-01	4.97e-01	0.28400	-0.201000	-2.00e-01	1.51e-01	1.54e-01
Platelet Aggregation (Plug Formation)	37	5.85e-03	3.12e-02	0.28300	-0.260000	-1.12e-01	6.11e-03	2.38e-01
Regulation of PTEN gene transcription	59	1.79e-02	7.47e-02	0.28300	-0.189000	-2.10e-01	1.19e-02	5.17e-03
Condensation of Prophase Chromosomes	12	3.78e-01	5.41e-01	0.28300	-0.164000	-2.30e-01	3.24e-01	1.67e-01
Serotonin Neurotransmitter Release Cycle	16	2.44e-01	4.31e-01	0.28300	-0.236000	-1.55e-01	1.02e-01	2.83e-01
Vasopressin regulates renal water homeostasis via Aquaporins	42	1.08e-02	5.00e-02	0.28200	-0.248000	-1.35e-01	5.43e-03	1.29e-01
SHC1 events in ERBB2 signaling	22	1.84e-01	3.69e-01	0.28200	-0.226000	-1.68e-01	6.67e-02	1.71e-01
Mitochondrial translation elongation	87	6.20e-05	7.21e-04	0.28100	0.249000	1.31e-01	5.94e-05	3.50e-02
Nitric oxide stimulates guanylate cyclase	22	5.02e-02	1.58e-01	0.28000	-0.257000	-1.10e-01	3.66e-02	3.70e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	2.68e-01	4.53e-01	0.28000	0.226000	1.65e-01	1.07e-01	2.39e-01
Synthesis of PIPs at the Golgi membrane	17	2.27e-01	4.13e-01	0.27900	-0.234000	-1.52e-01	9.44e-02	2.77e-01
mRNA Splicing - Minor Pathway	51	3.27e-04	2.92e-03	0.27900	0.263000	9.47e-02	1.16e-03	2.42e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	16	2.31e-01	4.17e-01	0.27900	-0.237000	-1.47e-01	1.00e-01	3.08e-01
Diseases of glycosylation	137	4.38e-05	5.64e-04	0.27800	-0.221000	-1.68e-01	7.75e-06	6.80e-04
Beta-catenin phosphorylation cascade	16	3.57e-01	5.27e-01	0.27800	-0.199000	-1.94e-01	1.69e-01	1.79e-01
RET signaling	41	2.59e-03	1.64e-02	0.27700	-0.258000	-9.99e-02	4.27e-03	2.68e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	3.38e-01	5.12e-01	0.27600	0.197000	1.94e-01	1.59e-01	1.66e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	1.72e-03	1.17e-02	0.27600	-0.274000	-3.23e-02	1.77e-02	7.80e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	23	5.99e-02	1.80e-01	0.27600	-0.250000	-1.16e-01	3.78e-02	3.36e-01
Cellular response to starvation	147	5.00e-05	6.18e-04	0.27500	0.212000	1.75e-01	8.74e-06	2.51e-04
FCERI mediated NF-kB activation	74	9.53e-03	4.58e-02	0.27500	0.193000	1.96e-01	4.14e-03	3.57e-03
COPI-dependent Golgi-to-ER retrograde traffic	81	4.50e-03	2.58e-02	0.27500	-0.176000	-2.11e-01	6.14e-03	1.04e-03
FGFRL1 modulation of FGFR1 signaling	13	2.77e-01	4.60e-01	0.27400	-0.134000	-2.39e-01	4.02e-01	1.36e-01
Regulation of RAS by GAPs	65	1.35e-02	6.01e-02	0.27400	0.176000	2.10e-01	1.41e-02	3.41e-03
CYP2E1 reactions	11	1.89e-01	3.74e-01	0.27400	-0.092900	-2.58e-01	5.94e-01	1.39e-01
Oncogenic MAPK signaling	76	4.53e-03	2.59e-02	0.27300	-0.217000	-1.65e-01	1.04e-03	1.29e-02
Cyclin E associated events during G1/S transition	81	6.14e-03	3.24e-02	0.27300	0.184000	2.01e-01	4.08e-03	1.75e-03
Transport of organic anions	10	2.93e-01	4.77e-01	0.27300	-0.248000	-1.12e-01	1.74e-01	5.39e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	12	3.97e-01	5.58e-01	0.27200	0.155000	2.24e-01	3.51e-01	1.80e-01
Assembly of the pre-replicative complex	82	5.77e-03	3.09e-02	0.27200	0.202000	1.82e-01	1.54e-03	4.45e-03
Keratan sulfate biosynthesis	28	1.07e-01	2.63e-01	0.27100	-0.226000	-1.51e-01	3.87e-02	1.67e-01
RAF activation	33	1.12e-01	2.70e-01	0.27100	-0.210000	-1.71e-01	3.64e-02	8.87e-02
Integration of energy metabolism	106	6.91e-05	7.81e-04	0.27100	-0.233000	-1.38e-01	3.34e-05	1.38e-02
ABC transporter disorders	75	3.57e-03	2.11e-02	0.27100	0.221000	1.56e-01	9.09e-04	1.97e-02
Diseases associated with glycosaminoglycan metabolism	38	1.05e-02	4.94e-02	0.27000	-0.246000	-1.11e-01	8.70e-03	2.35e-01
Cyclin A:Cdk2-associated events at S phase entry	83	5.89e-03	3.13e-02	0.27000	0.180000	2.01e-01	4.56e-03	1.57e-03
Anti-inflammatory response favouring Leishmania parasite infection	75	1.43e-04	1.45e-03	0.26900	-0.245000	-1.12e-01	2.46e-04	9.43e-02
Leishmania parasite growth and survival	75	1.43e-04	1.45e-03	0.26900	-0.245000	-1.12e-01	2.46e-04	9.43e-02
SARS-CoV-1-host interactions	90	8.35e-04	6.33e-03	0.26900	0.224000	1.49e-01	2.36e-04	1.47e-02
Signaling by FGFR4 in disease	11	4.95e-01	6.41e-01	0.26800	-0.206000	-1.72e-01	2.36e-01	3.24e-01
Switching of origins to a post-replicative state	90	4.42e-03	2.54e-02	0.26800	0.195000	1.85e-01	1.42e-03	2.42e-03
Class I peroxisomal membrane protein import	19	2.58e-01	4.43e-01	0.26800	0.217000	1.58e-01	1.02e-01	2.33e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	120	5.45e-04	4.44e-03	0.26700	0.173000	2.04e-01	1.07e-03	1.12e-04
Signaling by PDGF	52	3.68e-04	3.25e-03	0.26700	-0.253000	-8.49e-02	1.57e-03	2.89e-01
G beta:gamma signalling through PI3Kgamma	25	2.71e-02	1.04e-01	0.26700	-0.251000	-9.01e-02	2.96e-02	4.35e-01
Extra-nuclear estrogen signaling	73	1.95e-03	1.30e-02	0.26700	-0.228000	-1.39e-01	7.48e-04	4.05e-02
Sensory processing of sound by inner hair cells of the cochlea	62	6.70e-04	5.18e-03	0.26600	-0.243000	-1.09e-01	9.28e-04	1.38e-01
Biotin transport and metabolism	10	4.35e-01	5.90e-01	0.26600	-0.226000	-1.40e-01	2.15e-01	4.42e-01
Defects in vitamin and cofactor metabolism	20	1.88e-01	3.72e-01	0.26600	-0.140000	-2.26e-01	2.79e-01	7.97e-02
Butyrophilin (BTN) family interactions	12	4.92e-01	6.39e-01	0.26600	0.191000	1.85e-01	2.53e-01	2.66e-01
Synthesis of PE	12	4.91e-01	6.39e-01	0.26600	-0.183000	-1.93e-01	2.71e-01	2.48e-01
FCGR3A-mediated IL10 synthesis	37	4.16e-03	2.41e-02	0.26600	-0.251000	-8.61e-02	8.12e-03	3.65e-01
Respiratory electron transport	90	5.91e-04	4.66e-03	0.26600	0.226000	1.40e-01	2.13e-04	2.15e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	14	2.69e-01	4.53e-01	0.26500	-0.232000	-1.29e-01	1.32e-01	4.05e-01
Diseases of hemostasis	14	2.69e-01	4.53e-01	0.26500	-0.232000	-1.29e-01	1.32e-01	4.05e-01
Trafficking of GluR2-containing AMPA receptors	15	3.15e-01	4.94e-01	0.26500	-0.221000	-1.46e-01	1.38e-01	3.27e-01
Cell junction organization	79	4.17e-05	5.51e-04	0.26500	-0.245000	-9.97e-02	1.62e-04	1.25e-01
Calcitonin-like ligand receptors	10	4.09e-01	5.70e-01	0.26500	-0.229000	-1.32e-01	2.09e-01	4.69e-01
RHOA GTPase cycle	140	6.58e-08	2.31e-06	0.26400	-0.242000	-1.06e-01	7.52e-07	3.00e-02
Nucleotide salvage	21	2.07e-01	3.89e-01	0.26400	-0.219000	-1.47e-01	8.21e-02	2.43e-01
Tandem pore domain potassium channels	12	4.43e-01	5.97e-01	0.26400	-0.157000	-2.12e-01	3.46e-01	2.04e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	42	1.65e-02	7.07e-02	0.26300	-0.233000	-1.23e-01	8.93e-03	1.69e-01
Assembly and cell surface presentation of NMDA receptors	23	2.51e-01	4.38e-01	0.26300	-0.199000	-1.71e-01	9.79e-02	1.55e-01
Unblocking of NMDA receptors, glutamate binding and activation	19	3.30e-01	5.06e-01	0.26200	-0.194000	-1.76e-01	1.43e-01	1.84e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	2.61e-01	4.46e-01	0.26200	-0.140000	-2.21e-01	3.19e-01	1.14e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	2.61e-01	4.46e-01	0.26200	-0.140000	-2.21e-01	3.19e-01	1.14e-01
ADP signalling through P2Y purinoceptor 12	22	2.70e-01	4.54e-01	0.26100	-0.198000	-1.70e-01	1.07e-01	1.68e-01
Transcriptional regulation of granulopoiesis	31	1.26e-02	5.68e-02	0.26100	-0.246000	-8.56e-02	1.76e-02	4.10e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	18	2.71e-01	4.54e-01	0.26000	-0.216000	-1.46e-01	1.13e-01	2.85e-01
Initial triggering of complement	21	5.37e-02	1.66e-01	0.25900	0.085300	2.45e-01	4.99e-01	5.21e-02
Neurotoxicity of clostridium toxins	10	3.36e-01	5.11e-01	0.25800	-0.107000	-2.35e-01	5.57e-01	1.98e-01
Sphingolipid metabolism	81	8.63e-03	4.25e-02	0.25800	-0.166000	-1.98e-01	9.87e-03	2.10e-03
Neuronal System	371	2.85e-12	2.94e-10	0.25700	-0.215000	-1.42e-01	1.11e-12	2.52e-06
PINK1-PRKN Mediated Mitophagy	21	1.18e-03	8.41e-03	0.25700	0.255000	-3.04e-02	4.32e-02	8.09e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	29	1.53e-01	3.34e-01	0.25500	-0.206000	-1.50e-01	5.43e-02	1.63e-01
Phospholipase C-mediated cascade: FGFR1	16	4.14e-01	5.72e-01	0.25400	0.170000	1.89e-01	2.38e-01	1.90e-01
G-protein activation	24	1.76e-01	3.59e-01	0.25400	-0.214000	-1.38e-01	7.02e-02	2.40e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	3.75e-01	5.39e-01	0.25400	-0.216000	-1.35e-01	1.78e-01	4.01e-01
Biosynthesis of specialized proresolving mediators (SPMs)	19	3.27e-01	5.04e-01	0.25400	-0.198000	-1.59e-01	1.35e-01	2.30e-01
Prolonged ERK activation events	14	4.28e-01	5.84e-01	0.25400	-0.201000	-1.56e-01	1.93e-01	3.14e-01
FGFR1 ligand binding and activation	15	4.45e-01	5.99e-01	0.25400	0.177000	1.83e-01	2.37e-01	2.21e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	2.55e-01	4.40e-01	0.25400	0.188000	1.70e-01	1.03e-01	1.41e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	16	3.70e-01	5.36e-01	0.25300	-0.152000	-2.03e-01	2.93e-01	1.60e-01
Erythropoietin activates RAS	14	3.56e-01	5.26e-01	0.25300	-0.214000	-1.35e-01	1.66e-01	3.81e-01
Post-translational protein phosphorylation	100	4.75e-03	2.66e-02	0.25300	-0.183000	-1.75e-01	1.57e-03	2.50e-03
Neurotransmitter receptors and postsynaptic signal transmission	175	2.06e-05	3.45e-04	0.25300	-0.203000	-1.51e-01	3.67e-06	5.57e-04
KSRP (KHSRP) binds and destabilizes mRNA	17	2.89e-01	4.74e-01	0.25300	0.213000	1.36e-01	1.28e-01	3.33e-01
Keratan sulfate/keratin metabolism	33	1.15e-01	2.75e-01	0.25300	-0.207000	-1.46e-01	4.00e-02	1.48e-01
Regulation of NF-kappa B signaling	17	3.11e-01	4.89e-01	0.25300	0.141000	2.10e-01	3.14e-01	1.34e-01
Voltage gated Potassium channels	42	6.45e-02	1.91e-01	0.25300	-0.206000	-1.46e-01	2.06e-02	1.03e-01
DNA Replication Pre-Initiation	97	4.57e-03	2.59e-02	0.25300	0.192000	1.64e-01	1.09e-03	5.19e-03
Meiotic synapsis	32	4.48e-02	1.46e-01	0.25200	-0.227000	-1.11e-01	2.64e-02	2.78e-01
Diseases associated with visual transduction	11	3.78e-01	5.41e-01	0.25200	-0.223000	-1.18e-01	2.01e-01	4.96e-01
Diseases of the neuronal system	11	3.78e-01	5.41e-01	0.25200	-0.223000	-1.18e-01	2.01e-01	4.96e-01
Retinoid cycle disease events	11	3.78e-01	5.41e-01	0.25200	-0.223000	-1.18e-01	2.01e-01	4.96e-01
Lewis blood group biosynthesis	18	1.10e-01	2.67e-01	0.25200	-0.236000	-8.94e-02	8.35e-02	5.11e-01
Signaling by high-kinase activity BRAF mutants	32	1.03e-01	2.58e-01	0.25200	-0.211000	-1.37e-01	3.87e-02	1.81e-01
Purine catabolism	17	3.90e-01	5.52e-01	0.25100	0.191000	1.62e-01	1.72e-01	2.47e-01
CD209 (DC-SIGN) signaling	20	2.58e-01	4.43e-01	0.25100	-0.208000	-1.40e-01	1.07e-01	2.80e-01
Signal attenuation	10	1.46e-01	3.25e-01	0.25000	-0.247000	-3.97e-02	1.77e-01	8.28e-01
Condensation of Prometaphase Chromosomes	11	2.29e-02	9.15e-02	0.25000	0.054900	-2.44e-01	7.53e-01	1.62e-01
RAB GEFs exchange GTP for GDP on RABs	82	3.71e-03	2.16e-02	0.25000	-0.208000	-1.38e-01	1.10e-03	3.12e-02
Branched-chain amino acid catabolism	20	5.06e-02	1.59e-01	0.25000	-0.067800	-2.40e-01	6.00e-01	6.29e-02
HS-GAG degradation	18	2.70e-01	4.54e-01	0.25000	-0.212000	-1.32e-01	1.20e-01	3.32e-01
Signaling by ALK fusions and activated point mutants	51	6.46e-02	1.91e-01	0.24900	-0.188000	-1.64e-01	2.02e-02	4.29e-02
Signaling by ALK in cancer	51	6.46e-02	1.91e-01	0.24900	-0.188000	-1.64e-01	2.02e-02	4.29e-02
mRNA Splicing	184	1.59e-07	5.22e-06	0.24900	0.219000	1.18e-01	2.77e-07	5.86e-03
Signaling by ROBO receptors	203	2.02e-05	3.44e-04	0.24900	0.188000	1.64e-01	3.96e-06	5.75e-05
Activation of GABAB receptors	43	8.00e-02	2.20e-01	0.24800	-0.198000	-1.49e-01	2.49e-02	9.00e-02
GABA B receptor activation	43	8.00e-02	2.20e-01	0.24800	-0.198000	-1.49e-01	2.49e-02	9.00e-02
Xenobiotics	24	1.80e-01	3.63e-01	0.24800	-0.131000	-2.10e-01	2.66e-01	7.49e-02
Golgi-to-ER retrograde transport	115	2.10e-03	1.38e-02	0.24800	-0.160000	-1.89e-01	3.02e-03	4.65e-04
Signalling to ERKs	34	1.57e-01	3.38e-01	0.24700	-0.190000	-1.58e-01	5.48e-02	1.10e-01
Mitochondrial iron-sulfur cluster biogenesis	12	3.98e-01	5.59e-01	0.24700	0.213000	1.25e-01	2.01e-01	4.55e-01
PI3K events in ERBB2 signaling	16	4.15e-01	5.72e-01	0.24700	-0.156000	-1.91e-01	2.79e-01	1.85e-01
ERK/MAPK targets	20	3.55e-01	5.25e-01	0.24700	-0.183000	-1.65e-01	1.56e-01	2.01e-01
Platelet homeostasis	85	3.98e-04	3.42e-03	0.24700	-0.221000	-1.09e-01	4.16e-04	8.34e-02
HDL remodeling	10	6.02e-01	7.21e-01	0.24600	-0.170000	-1.78e-01	3.51e-01	3.30e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	2.66e-01	4.52e-01	0.24500	-0.075200	-2.34e-01	6.81e-01	2.01e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	3.90e-02	1.34e-01	0.24500	0.002280	-2.45e-01	9.89e-01	1.27e-01
Stimuli-sensing channels	96	3.07e-05	4.42e-04	0.24400	-0.226000	-9.23e-02	1.26e-04	1.18e-01
HDMs demethylate histones	18	2.50e-02	9.77e-02	0.24400	-0.243000	-2.51e-02	7.44e-02	8.54e-01
Semaphorin interactions	61	1.19e-03	8.42e-03	0.24400	-0.227000	-9.02e-02	2.19e-03	2.23e-01
TCR signaling	112	2.28e-03	1.50e-02	0.24400	0.152000	1.91e-01	5.46e-03	4.87e-04
Regulation of pyruvate dehydrogenase (PDH) complex	14	2.48e-01	4.34e-01	0.24400	-0.099000	-2.23e-01	5.21e-01	1.49e-01
Lysine catabolism	12	5.53e-01	6.85e-01	0.24300	-0.169000	-1.75e-01	3.10e-01	2.95e-01
APC-Cdc20 mediated degradation of Nek2A	26	2.44e-01	4.31e-01	0.24300	0.190000	1.51e-01	9.31e-02	1.83e-01
Bile acid and bile salt metabolism	45	8.01e-02	2.20e-01	0.24300	-0.193000	-1.47e-01	2.49e-02	8.77e-02
Processive synthesis on the lagging strand	14	1.20e-01	2.81e-01	0.24100	-0.057100	-2.35e-01	7.12e-01	1.28e-01
Regulation of TLR by endogenous ligand	17	4.73e-02	1.52e-01	0.24100	-0.238000	-3.83e-02	8.88e-02	7.84e-01
Na+/Cl- dependent neurotransmitter transporters	18	6.62e-02	1.94e-01	0.24100	0.057600	2.34e-01	6.72e-01	8.51e-02
Formation of apoptosome	10	4.30e-01	5.84e-01	0.24100	0.215000	1.10e-01	2.40e-01	5.47e-01
Regulation of the apoptosome activity	10	4.30e-01	5.84e-01	0.24100	0.215000	1.10e-01	2.40e-01	5.47e-01
G beta:gamma signalling through PLC beta	20	2.73e-01	4.55e-01	0.24100	-0.202000	-1.31e-01	1.18e-01	3.10e-01
Recycling of bile acids and salts	18	9.93e-02	2.53e-01	0.24100	-0.229000	-7.30e-02	9.19e-02	5.92e-01
Activation of kainate receptors upon glutamate binding	29	1.68e-01	3.52e-01	0.24100	-0.199000	-1.35e-01	6.36e-02	2.07e-01
Assembly of collagen fibrils and other multimeric structures	56	1.44e-04	1.45e-03	0.24100	-0.235000	-5.17e-02	2.34e-03	5.03e-01
Endogenous sterols	26	2.08e-01	3.90e-01	0.24000	-0.198000	-1.36e-01	8.10e-02	2.30e-01
Synthesis of very long-chain fatty acyl-CoAs	23	2.46e-01	4.32e-01	0.23900	-0.198000	-1.35e-01	1.00e-01	2.64e-01
HDACs deacetylate histones	29	2.51e-01	4.38e-01	0.23900	-0.170000	-1.68e-01	1.12e-01	1.18e-01
IRF3-mediated induction of type I IFN	11	5.39e-01	6.75e-01	0.23900	0.193000	1.41e-01	2.69e-01	4.17e-01
Signaling by Rho GTPases	589	6.10e-16	2.36e-13	0.23900	-0.198000	-1.34e-01	2.12e-16	2.51e-08
Metabolism of folate and pterines	16	4.52e-01	6.07e-01	0.23800	-0.155000	-1.81e-01	2.83e-01	2.10e-01
p130Cas linkage to MAPK signaling for integrins	15	1.17e-01	2.78e-01	0.23800	-0.231000	-5.97e-02	1.22e-01	6.89e-01
ABC transporters in lipid homeostasis	17	2.77e-01	4.60e-01	0.23800	-0.208000	-1.15e-01	1.37e-01	4.10e-01
Binding and Uptake of Ligands by Scavenger Receptors	41	7.96e-03	4.02e-02	0.23800	-0.225000	-7.79e-02	1.27e-02	3.88e-01
G alpha (z) signalling events	48	5.01e-02	1.58e-01	0.23800	-0.199000	-1.30e-01	1.72e-02	1.18e-01
Dopamine Neurotransmitter Release Cycle	20	3.81e-01	5.45e-01	0.23800	-0.177000	-1.58e-01	1.70e-01	2.21e-01
Telomere C-strand (Lagging Strand) Synthesis	32	3.28e-02	1.19e-01	0.23700	-0.085800	-2.21e-01	4.01e-01	3.04e-02
Lysosome Vesicle Biogenesis	33	1.92e-01	3.75e-01	0.23700	-0.151000	-1.82e-01	1.33e-01	6.96e-02
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	603	1.49e-15	3.83e-13	0.23600	-0.194000	-1.35e-01	3.67e-16	1.50e-08
Assembly of active LPL and LIPC lipase complexes	17	1.87e-01	3.71e-01	0.23600	0.091000	2.17e-01	5.16e-01	1.21e-01
Lagging Strand Synthesis	19	6.34e-02	1.88e-01	0.23600	-0.055200	-2.29e-01	6.77e-01	8.38e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12	2.40e-01	4.28e-01	0.23500	-0.223000	-7.44e-02	1.80e-01	6.55e-01
Regulation of insulin secretion	77	2.36e-03	1.53e-02	0.23500	-0.209000	-1.09e-01	1.54e-03	9.83e-02
Vitamin D (calciferol) metabolism	12	5.74e-01	7.03e-01	0.23500	-0.167000	-1.66e-01	3.16e-01	3.20e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	11	5.23e-01	6.62e-01	0.23500	0.132000	1.95e-01	4.49e-01	2.64e-01
Regulation of TP53 Activity through Methylation	18	3.28e-01	5.04e-01	0.23500	0.128000	1.97e-01	3.48e-01	1.47e-01
Metabolism of cofactors	19	7.86e-03	4.00e-02	0.23400	0.019700	-2.33e-01	8.82e-01	7.83e-02
Aquaporin-mediated transport	51	2.08e-02	8.46e-02	0.23400	-0.206000	-1.10e-01	1.08e-02	1.75e-01
Cellular hexose transport	21	3.54e-01	5.25e-01	0.23300	0.147000	1.82e-01	2.45e-01	1.50e-01
Downstream signal transduction	29	3.38e-02	1.22e-01	0.23300	-0.221000	-7.28e-02	3.94e-02	4.97e-01
Defective pyroptosis	11	6.06e-01	7.25e-01	0.23200	-0.158000	-1.70e-01	3.64e-01	3.28e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	21	5.48e-02	1.68e-01	0.23200	-0.055700	-2.25e-01	6.58e-01	7.44e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins	15	2.82e-01	4.66e-01	0.23200	-0.209000	-9.91e-02	1.61e-01	5.06e-01
Glutathione synthesis and recycling	12	4.12e-01	5.71e-01	0.23100	-0.109000	-2.04e-01	5.15e-01	2.22e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	27	3.01e-01	4.84e-01	0.23000	-0.158000	-1.67e-01	1.54e-01	1.33e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	3.71e-01	5.36e-01	0.23000	0.117000	1.98e-01	4.34e-01	1.83e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	3.71e-01	5.36e-01	0.23000	0.117000	1.98e-01	4.34e-01	1.83e-01
Biosynthesis of DHA-derived SPMs	17	4.72e-01	6.22e-01	0.23000	-0.161000	-1.64e-01	2.50e-01	2.41e-01
NOTCH1 Intracellular Domain Regulates Transcription	44	1.25e-01	2.89e-01	0.23000	-0.178000	-1.46e-01	4.16e-02	9.30e-02
Signaling by NTRK2 (TRKB)	25	3.26e-01	5.03e-01	0.23000	-0.170000	-1.55e-01	1.41e-01	1.80e-01
Negative regulation of MET activity	20	4.13e-01	5.72e-01	0.23000	-0.160000	-1.65e-01	2.15e-01	2.02e-01
Glycerophospholipid biosynthesis	114	2.68e-03	1.66e-02	0.23000	-0.185000	-1.36e-01	6.21e-04	1.23e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	95	1.77e-03	1.20e-02	0.23000	0.199000	1.15e-01	8.08e-04	5.21e-02
Digestion	18	1.56e-01	3.36e-01	0.23000	-0.215000	-8.05e-02	1.14e-01	5.54e-01
Ion homeostasis	50	1.76e-02	7.40e-02	0.22900	-0.206000	-1.00e-01	1.16e-02	2.21e-01
Translocation of ZAP-70 to Immunological synapse	17	3.70e-01	5.36e-01	0.22900	0.125000	1.92e-01	3.71e-01	1.70e-01
Regulation of TNFR1 signaling	37	2.02e-01	3.86e-01	0.22800	0.159000	1.63e-01	9.35e-02	8.67e-02
Hemostasis	555	5.17e-14	1.00e-11	0.22700	-0.189000	-1.26e-01	2.09e-14	3.59e-07
Transmission across Chemical Synapses	237	2.03e-06	5.31e-05	0.22700	-0.189000	-1.27e-01	5.35e-07	7.67e-04
FGFR1c ligand binding and activation	11	6.19e-01	7.38e-01	0.22700	0.154000	1.67e-01	3.76e-01	3.38e-01
Signaling by activated point mutants of FGFR1	11	6.19e-01	7.38e-01	0.22700	0.154000	1.67e-01	3.76e-01	3.38e-01
Blood group systems biosynthesis	22	1.49e-01	3.28e-01	0.22700	-0.207000	-9.19e-02	9.21e-02	4.55e-01
G alpha (s) signalling events	153	2.30e-05	3.67e-04	0.22600	-0.199000	-1.08e-01	2.08e-05	2.13e-02
Chaperone Mediated Autophagy	19	4.37e-01	5.92e-01	0.22600	0.152000	1.68e-01	2.51e-01	2.05e-01
Interleukin receptor SHC signaling	24	1.82e-01	3.66e-01	0.22600	-0.200000	-1.06e-01	9.06e-02	3.68e-01
Negative regulation of the PI3K/AKT network	111	4.73e-03	2.66e-02	0.22600	-0.179000	-1.37e-01	1.08e-03	1.24e-02
Oxidative Stress Induced Senescence	66	5.67e-02	1.73e-01	0.22600	-0.168000	-1.51e-01	1.80e-02	3.44e-02
PPARA activates gene expression	114	7.26e-03	3.73e-02	0.22500	-0.168000	-1.50e-01	1.96e-03	5.50e-03
Apoptotic factor-mediated response	17	7.66e-02	2.14e-01	0.22500	0.222000	3.93e-02	1.13e-01	7.79e-01
RHO GTPases activate PKNs	34	2.25e-01	4.12e-01	0.22500	-0.170000	-1.48e-01	8.67e-02	1.35e-01
RHO GTPases Activate ROCKs	19	2.09e-01	3.90e-01	0.22500	-0.204000	-9.32e-02	1.23e-01	4.82e-01
Potassium Channels	102	5.00e-03	2.77e-02	0.22400	-0.184000	-1.28e-01	1.32e-03	2.49e-02
Attenuation phase	25	3.46e-01	5.20e-01	0.22400	0.164000	1.53e-01	1.55e-01	1.87e-01
Thrombin signalling through proteinase activated receptors (PARs)	32	7.36e-02	2.09e-01	0.22400	-0.203000	-9.32e-02	4.63e-02	3.62e-01
Digestion and absorption	23	3.41e-02	1.22e-01	0.22300	-0.220000	-4.02e-02	6.82e-02	7.38e-01
mRNA Splicing - Major Pathway	174	4.43e-06	1.05e-04	0.22300	0.198000	1.03e-01	6.40e-06	1.91e-02
Cargo concentration in the ER	32	1.86e-01	3.71e-01	0.22300	-0.126000	-1.84e-01	2.17e-01	7.13e-02
Eicosanoid ligand-binding receptors	14	3.23e-01	5.01e-01	0.22300	-0.203000	-9.30e-02	1.89e-01	5.47e-01
EPHB-mediated forward signaling	34	2.22e-01	4.08e-01	0.22300	-0.172000	-1.42e-01	8.34e-02	1.51e-01
Degradation of the extracellular matrix	108	5.90e-04	4.66e-03	0.22300	-0.197000	-1.05e-01	4.10e-04	5.98e-02
Hedgehog ‘on’ state	83	2.68e-02	1.04e-01	0.22200	0.142000	1.70e-01	2.48e-02	7.27e-03
Phase 2 - plateau phase	14	6.25e-02	1.86e-01	0.22200	-0.222000	-2.60e-03	1.51e-01	9.87e-01
HCMV Early Events	55	3.56e-02	1.25e-01	0.22200	-0.113000	-1.91e-01	1.48e-01	1.44e-02
Amine ligand-binding receptors	41	1.79e-01	3.63e-01	0.22200	-0.165000	-1.48e-01	6.72e-02	1.02e-01
Sema4D induced cell migration and growth-cone collapse	20	7.37e-02	2.09e-01	0.22100	-0.216000	-5.02e-02	9.49e-02	6.97e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	14	3.01e-01	4.84e-01	0.22100	0.086100	2.04e-01	5.77e-01	1.87e-01
Regulation of IFNG signaling	14	4.56e-01	6.11e-01	0.22000	-0.118000	-1.86e-01	4.46e-01	2.27e-01
Nuclear events mediated by NFE2L2	76	4.60e-02	1.49e-01	0.22000	0.152000	1.59e-01	2.15e-02	1.66e-02
SUMOylation of chromatin organization proteins	54	8.28e-02	2.25e-01	0.22000	-0.133000	-1.75e-01	9.02e-02	2.59e-02
STING mediated induction of host immune responses	13	5.07e-01	6.49e-01	0.22000	0.183000	1.23e-01	2.54e-01	4.44e-01
Sema4D in semaphorin signaling	24	8.06e-02	2.21e-01	0.22000	-0.209000	-6.84e-02	7.63e-02	5.62e-01
Phosphorylation of CD3 and TCR zeta chains	20	4.24e-01	5.81e-01	0.22000	0.140000	1.69e-01	2.77e-01	1.91e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	6.46e-01	7.55e-01	0.22000	0.138000	1.71e-01	4.50e-01	3.50e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	2.19e-01	4.04e-01	0.21900	0.186000	1.16e-01	9.41e-02	2.98e-01
Inactivation, recovery and regulation of the phototransduction cascade	31	1.27e-01	2.93e-01	0.21900	-0.193000	-1.03e-01	6.27e-02	3.21e-01
Potential therapeutics for SARS	92	2.48e-02	9.73e-02	0.21900	-0.149000	-1.60e-01	1.32e-02	8.04e-03
Ion channel transport	168	1.02e-06	2.76e-05	0.21900	-0.201000	-8.66e-02	6.94e-06	5.25e-02
Keratan sulfate degradation	12	2.43e-01	4.30e-01	0.21900	-0.211000	-5.67e-02	2.05e-01	7.34e-01
TRP channels	24	1.48e-01	3.28e-01	0.21800	-0.199000	-8.90e-02	9.08e-02	4.50e-01
Vesicle-mediated transport	623	1.62e-11	1.32e-09	0.21800	-0.163000	-1.45e-01	3.12e-12	6.38e-10
Platelet activation, signaling and aggregation	245	2.65e-06	6.60e-05	0.21800	-0.182000	-1.18e-01	8.51e-07	1.40e-03
Polo-like kinase mediated events	16	5.96e-02	1.80e-01	0.21700	-0.012100	-2.17e-01	9.33e-01	1.33e-01
CD28 dependent PI3K/Akt signaling	22	4.11e-02	1.38e-01	0.21700	-0.214000	-3.42e-02	8.20e-02	7.81e-01
Scavenging by Class A Receptors	19	3.62e-01	5.30e-01	0.21700	-0.183000	-1.16e-01	1.68e-01	3.80e-01
Cardiac conduction	123	2.48e-03	1.59e-02	0.21700	-0.178000	-1.23e-01	6.43e-04	1.82e-02
Aspirin ADME	44	1.19e-01	2.80e-01	0.21600	-0.124000	-1.78e-01	1.55e-01	4.16e-02
Complex I biogenesis	49	4.31e-02	1.43e-01	0.21600	0.190000	1.03e-01	2.11e-02	2.14e-01
SUMOylation of DNA damage response and repair proteins	71	3.41e-02	1.22e-01	0.21600	-0.125000	-1.76e-01	6.83e-02	1.01e-02
Processing of Capped Intron-Containing Pre-mRNA	232	3.56e-08	1.31e-06	0.21600	0.196000	9.16e-02	2.68e-07	1.61e-02
Signaling by TGF-beta Receptor Complex	90	3.03e-02	1.12e-01	0.21600	-0.153000	-1.53e-01	1.21e-02	1.23e-02
TNFR1-induced proapoptotic signaling	13	5.72e-01	7.01e-01	0.21600	0.134000	1.69e-01	4.03e-01	2.91e-01
Membrane Trafficking	585	2.09e-10	1.08e-08	0.21500	-0.157000	-1.47e-01	7.71e-11	1.14e-09
Miscellaneous transport and binding events	21	4.43e-01	5.97e-01	0.21500	-0.147000	-1.56e-01	2.43e-01	2.15e-01
Rab regulation of trafficking	113	2.76e-03	1.71e-02	0.21400	-0.181000	-1.15e-01	9.03e-04	3.45e-02
Pre-NOTCH Expression and Processing	61	2.62e-03	1.65e-02	0.21400	-0.203000	-6.79e-02	6.16e-03	3.59e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	13	3.69e-01	5.36e-01	0.21400	-0.086600	-1.95e-01	5.89e-01	2.23e-01
Metabolism of RNA	639	7.14e-17	3.68e-14	0.21400	0.186000	1.05e-01	8.56e-16	5.76e-06
Regulation of lipid metabolism by PPARalpha	116	1.06e-02	4.99e-02	0.21300	-0.161000	-1.41e-01	2.80e-03	8.88e-03
Nuclear Envelope Breakdown	50	6.63e-02	1.94e-01	0.21300	-0.111000	-1.82e-01	1.74e-01	2.60e-02
Diseases of metabolism	234	4.82e-05	6.01e-04	0.21300	-0.169000	-1.29e-01	8.46e-06	6.37e-04
Interleukin-37 signaling	20	1.82e-01	3.66e-01	0.21200	-0.197000	-7.64e-02	1.27e-01	5.54e-01
RMTs methylate histone arginines	30	3.18e-01	4.97e-01	0.21100	-0.158000	-1.41e-01	1.35e-01	1.81e-01
Late SARS-CoV-2 Infection Events	67	4.50e-02	1.47e-01	0.21100	-0.173000	-1.21e-01	1.40e-02	8.71e-02
VxPx cargo-targeting to cilium	20	1.69e-01	3.52e-01	0.21100	-0.198000	-7.25e-02	1.25e-01	5.75e-01
The phototransduction cascade	32	1.27e-01	2.93e-01	0.21100	-0.188000	-9.64e-02	6.58e-02	3.45e-01
Fatty acyl-CoA biosynthesis	36	2.63e-01	4.48e-01	0.21100	-0.151000	-1.47e-01	1.17e-01	1.26e-01
activated TAK1 mediates p38 MAPK activation	16	4.18e-01	5.73e-01	0.21100	-0.181000	-1.08e-01	2.10e-01	4.55e-01
Cell death signalling via NRAGE, NRIF and NADE	69	1.66e-02	7.09e-02	0.21000	-0.184000	-1.01e-01	8.07e-03	1.46e-01
Pentose phosphate pathway	12	6.33e-01	7.45e-01	0.21000	-0.158000	-1.38e-01	3.42e-01	4.08e-01
DARPP-32 events	24	3.25e-01	5.02e-01	0.21000	-0.174000	-1.18e-01	1.41e-01	3.17e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	5.75e-01	7.04e-01	0.20900	-0.132000	-1.62e-01	3.93e-01	2.93e-01
SUMOylation of transcription cofactors	43	2.04e-01	3.86e-01	0.20900	-0.141000	-1.54e-01	1.09e-01	8.03e-02
Downstream signaling events of B Cell Receptor (BCR)	78	5.47e-02	1.68e-01	0.20900	0.156000	1.38e-01	1.70e-02	3.48e-02
Signaling by Receptor Tyrosine Kinases	493	7.89e-10	3.69e-08	0.20800	-0.169000	-1.21e-01	1.35e-10	3.98e-06
RUNX2 regulates bone development	29	2.52e-01	4.38e-01	0.20700	-0.173000	-1.14e-01	1.06e-01	2.89e-01
Transport to the Golgi and subsequent modification	165	1.88e-03	1.26e-02	0.20700	-0.133000	-1.59e-01	3.27e-03	4.05e-04
Intrinsic Pathway of Fibrin Clot Formation	21	1.06e-01	2.61e-01	0.20700	-0.200000	-5.32e-02	1.12e-01	6.73e-01
Glucocorticoid biosynthesis	10	2.89e-01	4.74e-01	0.20700	0.039300	2.04e-01	8.29e-01	2.65e-01
MAPK targets/ Nuclear events mediated by MAP kinases	29	3.52e-01	5.24e-01	0.20700	-0.151000	-1.42e-01	1.59e-01	1.86e-01
rRNA modification in the nucleus and cytosol	55	3.54e-02	1.25e-01	0.20700	0.183000	9.59e-02	1.86e-02	2.18e-01
Inwardly rectifying K+ channels	35	2.30e-01	4.16e-01	0.20700	-0.167000	-1.23e-01	8.82e-02	2.09e-01
Sialic acid metabolism	33	3.04e-01	4.84e-01	0.20700	-0.152000	-1.40e-01	1.31e-01	1.64e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	6.30e-01	7.44e-01	0.20600	-0.130000	-1.60e-01	4.36e-01	3.36e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	2.37e-01	4.24e-01	0.20600	-0.202000	-4.12e-02	2.26e-01	8.05e-01
Mitochondrial Fatty Acid Beta-Oxidation	35	2.31e-01	4.16e-01	0.20500	-0.120000	-1.66e-01	2.20e-01	8.91e-02
CTLA4 inhibitory signaling	21	1.17e-01	2.78e-01	0.20400	-0.197000	-5.38e-02	1.18e-01	6.70e-01
Phase 4 - resting membrane potential	19	5.17e-01	6.58e-01	0.20400	-0.145000	-1.43e-01	2.73e-01	2.80e-01
Meiosis	56	1.40e-01	3.14e-01	0.20400	-0.150000	-1.38e-01	5.17e-02	7.41e-02
Regulation of RUNX2 expression and activity	71	7.47e-02	2.11e-01	0.20400	0.131000	1.56e-01	5.54e-02	2.32e-02
Synthesis of PA	35	9.74e-02	2.51e-01	0.20300	-0.184000	-8.53e-02	5.89e-02	3.82e-01
Transcriptional regulation by RUNX3	93	1.21e-02	5.49e-02	0.20300	0.108000	1.72e-01	7.09e-02	4.17e-03
EPH-Ephrin signaling	90	2.47e-02	9.73e-02	0.20300	-0.164000	-1.18e-01	6.97e-03	5.21e-02
p75 NTR receptor-mediated signalling	89	2.27e-02	9.12e-02	0.20200	-0.166000	-1.15e-01	6.70e-03	6.04e-02
RUNX2 regulates osteoblast differentiation	22	3.60e-01	5.30e-01	0.20200	-0.170000	-1.09e-01	1.67e-01	3.78e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	4.11e-01	5.71e-01	0.20200	0.160000	1.22e-01	1.83e-01	3.10e-01
Purine ribonucleoside monophosphate biosynthesis	11	3.03e-01	4.84e-01	0.20100	-0.045000	-1.96e-01	7.96e-01	2.60e-01
Interaction With Cumulus Cells And The Zona Pellucida	11	4.85e-01	6.34e-01	0.20100	0.083900	1.83e-01	6.30e-01	2.94e-01
GPVI-mediated activation cascade	32	7.42e-02	2.10e-01	0.20100	-0.189000	-6.83e-02	6.42e-02	5.03e-01
Degradation of beta-catenin by the destruction complex	81	4.19e-02	1.40e-01	0.20000	0.119000	1.61e-01	6.35e-02	1.22e-02
Senescence-Associated Secretory Phenotype (SASP)	53	1.69e-01	3.52e-01	0.20000	0.139000	1.44e-01	7.99e-02	6.92e-02
Diseases associated with N-glycosylation of proteins	19	2.32e-01	4.17e-01	0.20000	-0.071800	-1.87e-01	5.88e-01	1.58e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	2.13e-01	3.96e-01	0.20000	-0.158000	-1.22e-01	7.91e-02	1.78e-01
Presynaptic function of Kainate receptors	21	3.25e-01	5.02e-01	0.19900	-0.175000	-9.58e-02	1.65e-01	4.47e-01
Processing of Capped Intronless Pre-mRNA	28	3.17e-02	1.16e-01	0.19900	-0.030500	-1.97e-01	7.80e-01	7.16e-02
Physiological factors	14	6.28e-01	7.43e-01	0.19900	-0.135000	-1.46e-01	3.81e-01	3.46e-01
MAPK6/MAPK4 signaling	89	5.35e-02	1.66e-01	0.19900	0.138000	1.43e-01	2.46e-02	1.97e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	1.73e-01	3.57e-01	0.19800	-0.073100	-1.84e-01	5.35e-01	1.18e-01
EPHA-mediated growth cone collapse	15	1.71e-01	3.54e-01	0.19800	-0.195000	-3.40e-02	1.91e-01	8.20e-01
Anchoring of the basal body to the plasma membrane	92	3.16e-02	1.16e-01	0.19800	-0.119000	-1.58e-01	4.83e-02	8.75e-03
Signaling by RAF1 mutants	37	7.78e-02	2.18e-01	0.19800	-0.182000	-7.69e-02	5.49e-02	4.18e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	11	6.28e-01	7.43e-01	0.19800	-0.164000	-1.10e-01	3.45e-01	5.28e-01
DNA Replication	125	8.53e-03	4.23e-02	0.19700	0.159000	1.16e-01	2.15e-03	2.48e-02
Inactivation of CSF3 (G-CSF) signaling	23	4.72e-01	6.22e-01	0.19700	0.144000	1.34e-01	2.31e-01	2.67e-01
Mitotic Prophase	78	3.13e-02	1.15e-01	0.19700	-0.105000	-1.66e-01	1.09e-01	1.11e-02
Initiation of Nuclear Envelope (NE) Reformation	18	1.91e-01	3.75e-01	0.19600	-0.053600	-1.89e-01	6.94e-01	1.66e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	20	3.11e-01	4.89e-01	0.19500	-0.085300	-1.75e-01	5.09e-01	1.74e-01
Detoxification of Reactive Oxygen Species	35	3.28e-01	5.04e-01	0.19500	0.134000	1.41e-01	1.69e-01	1.47e-01
Pyruvate metabolism	29	3.54e-01	5.25e-01	0.19500	-0.118000	-1.54e-01	2.70e-01	1.50e-01
Norepinephrine Neurotransmitter Release Cycle	16	3.66e-01	5.32e-01	0.19500	-0.177000	-7.97e-02	2.19e-01	5.81e-01
Signaling by Nuclear Receptors	237	6.14e-05	7.19e-04	0.19400	-0.162000	-1.07e-01	1.75e-05	4.64e-03
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	104	2.87e-02	1.08e-01	0.19300	-0.151000	-1.20e-01	7.69e-03	3.37e-02
G beta:gamma signalling through CDC42	19	5.26e-01	6.62e-01	0.19300	-0.150000	-1.21e-01	2.57e-01	3.60e-01
Formation of Fibrin Clot (Clotting Cascade)	37	4.98e-02	1.58e-01	0.19300	-0.184000	-5.99e-02	5.33e-02	5.28e-01
HCMV Infection	79	1.46e-02	6.44e-02	0.19200	-0.087800	-1.71e-01	1.77e-01	8.51e-03
G alpha (q) signalling events	206	7.92e-06	1.68e-04	0.19200	-0.173000	-8.28e-02	1.80e-05	4.03e-02
FGFR2 ligand binding and activation	19	5.58e-01	6.90e-01	0.19200	0.137000	1.34e-01	3.01e-01	3.11e-01
Base Excision Repair	45	5.42e-02	1.67e-01	0.19200	-0.074500	-1.77e-01	3.87e-01	4.02e-02
CaMK IV-mediated phosphorylation of CREB	10	8.21e-02	2.24e-01	0.19200	-0.169000	8.98e-02	3.54e-01	6.23e-01
IKK complex recruitment mediated by RIP1	22	4.38e-01	5.93e-01	0.19100	0.110000	1.56e-01	3.73e-01	2.04e-01
Regulation of PTEN stability and activity	66	1.18e-01	2.79e-01	0.19000	0.121000	1.47e-01	8.90e-02	3.88e-02
Synthesis of DNA	118	1.74e-02	7.33e-02	0.19000	0.151000	1.15e-01	4.48e-03	3.02e-02
Activation of gene expression by SREBF (SREBP)	42	1.97e-01	3.82e-01	0.18900	-0.157000	-1.05e-01	7.78e-02	2.38e-01
Transferrin endocytosis and recycling	30	3.34e-01	5.10e-01	0.18800	-0.108000	-1.54e-01	3.06e-01	1.44e-01
Inhibition of DNA recombination at telomere	20	3.69e-01	5.36e-01	0.18800	0.166000	8.74e-02	1.98e-01	4.98e-01
Josephin domain DUBs	11	2.13e-01	3.96e-01	0.18800	0.188000	3.14e-03	2.82e-01	9.86e-01
Hyaluronan metabolism	17	2.38e-01	4.25e-01	0.18700	-0.180000	-5.05e-02	1.98e-01	7.18e-01
ATF6 (ATF6-alpha) activates chaperones	11	5.80e-01	7.06e-01	0.18700	0.086900	1.66e-01	6.18e-01	3.41e-01
Metal ion SLC transporters	25	2.42e-01	4.28e-01	0.18700	-0.077400	-1.70e-01	5.03e-01	1.42e-01
Metabolism of lipids	696	1.12e-09	4.82e-08	0.18700	-0.142000	-1.21e-01	1.66e-10	4.57e-08
Crosslinking of collagen fibrils	10	1.22e-01	2.85e-01	0.18600	-0.176000	6.01e-02	3.36e-01	7.42e-01
Signaling by Retinoic Acid	41	3.04e-01	4.84e-01	0.18500	-0.126000	-1.36e-01	1.63e-01	1.31e-01
RNA Pol II CTD phosphorylation and interaction with CE	26	4.30e-01	5.84e-01	0.18500	0.147000	1.13e-01	1.94e-01	3.18e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	26	4.30e-01	5.84e-01	0.18500	0.147000	1.13e-01	1.94e-01	3.18e-01
Chromatin modifying enzymes	186	8.25e-05	9.11e-04	0.18500	-0.166000	-8.31e-02	9.70e-05	5.04e-02
Chromatin organization	186	8.25e-05	9.11e-04	0.18500	-0.166000	-8.31e-02	9.70e-05	5.04e-02
Signaling by NOTCH1	69	1.27e-01	2.93e-01	0.18500	-0.141000	-1.21e-01	4.34e-02	8.30e-02
ER to Golgi Anterograde Transport	134	5.35e-03	2.92e-02	0.18500	-0.099400	-1.56e-01	4.68e-02	1.77e-03
Activation of G protein gated Potassium channels	29	3.35e-01	5.10e-01	0.18500	-0.155000	-1.02e-01	1.49e-01	3.44e-01
G protein gated Potassium channels	29	3.35e-01	5.10e-01	0.18500	-0.155000	-1.02e-01	1.49e-01	3.44e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	29	3.35e-01	5.10e-01	0.18500	-0.155000	-1.02e-01	1.49e-01	3.44e-01
TGF-beta receptor signaling activates SMADs	45	2.72e-01	4.54e-01	0.18500	-0.125000	-1.36e-01	1.47e-01	1.14e-01
Signaling by ERBB2 KD Mutants	24	5.04e-01	6.47e-01	0.18500	-0.132000	-1.30e-01	2.63e-01	2.72e-01
TNF signaling	45	2.63e-01	4.48e-01	0.18400	0.119000	1.40e-01	1.66e-01	1.03e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	3.82e-01	5.46e-01	0.18400	-0.170000	-7.11e-02	2.40e-01	6.22e-01
Phenylalanine and tyrosine metabolism	10	6.74e-01	7.79e-01	0.18400	-0.156000	-9.76e-02	3.93e-01	5.93e-01
Amino acids regulate mTORC1	52	1.60e-01	3.40e-01	0.18300	-0.151000	-1.04e-01	5.94e-02	1.95e-01
PCP/CE pathway	90	6.85e-02	1.99e-01	0.18300	0.117000	1.41e-01	5.44e-02	2.08e-02
Interleukin-17 signaling	66	1.03e-01	2.57e-01	0.18300	-0.150000	-1.05e-01	3.51e-02	1.39e-01
CRMPs in Sema3A signaling	15	5.35e-01	6.71e-01	0.18300	-0.158000	-9.28e-02	2.90e-01	5.34e-01
DNA Damage Recognition in GG-NER	36	2.36e-02	9.35e-02	0.18300	0.181000	2.78e-02	6.07e-02	7.73e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	3.35e-02	1.21e-01	0.18300	0.112000	-1.44e-01	4.68e-01	3.50e-01
Regulation of IFNA/IFNB signaling	22	8.48e-03	4.21e-02	0.18200	0.073600	-1.67e-01	5.50e-01	1.75e-01
SUMO E3 ligases SUMOylate target proteins	158	1.09e-02	5.03e-02	0.18200	-0.137000	-1.20e-01	2.85e-03	9.31e-03
COPI-independent Golgi-to-ER retrograde traffic	34	3.83e-01	5.47e-01	0.18200	-0.121000	-1.36e-01	2.23e-01	1.71e-01
TRAF3-dependent IRF activation pathway	15	5.34e-01	6.70e-01	0.18100	0.090700	1.57e-01	5.43e-01	2.92e-01
COPII-mediated vesicle transport	66	7.00e-02	2.01e-01	0.18100	-0.092300	-1.56e-01	1.95e-01	2.88e-02
Fcgamma receptor (FCGR) dependent phagocytosis	82	3.87e-03	2.25e-02	0.18100	-0.171000	-5.93e-02	7.49e-03	3.53e-01
G1/S-Specific Transcription	28	7.98e-02	2.20e-01	0.18100	-0.037600	-1.77e-01	7.30e-01	1.06e-01
G beta:gamma signalling through BTK	17	5.50e-01	6.82e-01	0.18000	-0.150000	-1.00e-01	2.84e-01	4.74e-01
Prefoldin mediated transfer of substrate to CCT/TriC	27	1.45e-01	3.23e-01	0.18000	0.172000	5.49e-02	1.23e-01	6.21e-01
Regulation of gene expression in beta cells	21	3.52e-02	1.25e-01	0.18000	-0.022700	1.79e-01	8.57e-01	1.57e-01
SUMOylation	164	1.17e-02	5.39e-02	0.18000	-0.132000	-1.23e-01	3.60e-03	6.74e-03
Signaling by Erythropoietin	25	2.26e-01	4.13e-01	0.18000	-0.167000	-6.68e-02	1.49e-01	5.63e-01
Removal of the Flap Intermediate	13	2.45e-01	4.31e-01	0.17900	-0.020400	-1.78e-01	8.99e-01	2.66e-01
Glycosphingolipid metabolism	40	1.15e-01	2.75e-01	0.17900	-0.072400	-1.64e-01	4.28e-01	7.30e-02
Intra-Golgi and retrograde Golgi-to-ER traffic	181	8.14e-03	4.09e-02	0.17900	-0.126000	-1.27e-01	3.43e-03	3.15e-03
Prostacyclin signalling through prostacyclin receptor	19	3.00e-01	4.84e-01	0.17800	-0.167000	-6.12e-02	2.07e-01	6.44e-01
Signal Transduction	2409	1.23e-34	1.90e-31	0.17800	-0.149000	-9.63e-02	8.87e-34	6.47e-15
Mitophagy	27	2.54e-02	9.88e-02	0.17700	0.177000	-6.00e-03	1.11e-01	9.57e-01
ERBB2 Activates PTK6 Signaling	13	7.10e-01	8.05e-01	0.17700	-0.128000	-1.23e-01	4.25e-01	4.43e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	7.50e-02	2.11e-01	0.17700	0.170000	-5.05e-02	2.71e-01	7.44e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	3.19e-01	4.97e-01	0.17700	-0.165000	-6.33e-02	2.12e-01	6.33e-01
Receptor-type tyrosine-protein phosphatases	16	1.49e-01	3.28e-01	0.17700	-0.177000	-8.36e-03	2.21e-01	9.54e-01
Leading Strand Synthesis	13	8.96e-02	2.37e-01	0.17700	0.052200	-1.69e-01	7.44e-01	2.92e-01
Polymerase switching	13	8.96e-02	2.37e-01	0.17700	0.052200	-1.69e-01	7.44e-01	2.92e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	101	1.10e-03	7.99e-03	0.17700	-0.168000	-5.49e-02	3.55e-03	3.40e-01
Defective Intrinsic Pathway for Apoptosis	25	2.82e-01	4.66e-01	0.17600	0.160000	7.36e-02	1.65e-01	5.24e-01
Amino acid transport across the plasma membrane	30	1.76e-01	3.59e-01	0.17600	-0.164000	-6.49e-02	1.20e-01	5.38e-01
mTORC1-mediated signalling	23	5.38e-01	6.74e-01	0.17600	-0.133000	-1.15e-01	2.68e-01	3.40e-01
Resolution of Abasic Sites (AP sites)	37	1.22e-01	2.85e-01	0.17600	-0.065700	-1.63e-01	4.89e-01	8.57e-02
Cell-extracellular matrix interactions	14	4.43e-02	1.45e-01	0.17500	-0.106000	1.39e-01	4.92e-01	3.67e-01
HIV Transcription Initiation	43	2.02e-01	3.86e-01	0.17400	0.150000	8.96e-02	8.94e-02	3.09e-01
RNA Polymerase II HIV Promoter Escape	43	2.02e-01	3.86e-01	0.17400	0.150000	8.96e-02	8.94e-02	3.09e-01
RNA Polymerase II Promoter Escape	43	2.02e-01	3.86e-01	0.17400	0.150000	8.96e-02	8.94e-02	3.09e-01
RNA Polymerase II Transcription Initiation	43	2.02e-01	3.86e-01	0.17400	0.150000	8.96e-02	8.94e-02	3.09e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	43	2.02e-01	3.86e-01	0.17400	0.150000	8.96e-02	8.94e-02	3.09e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	43	2.02e-01	3.86e-01	0.17400	0.150000	8.96e-02	8.94e-02	3.09e-01
PI3K/AKT Signaling in Cancer	103	5.16e-03	2.84e-02	0.17400	-0.159000	-7.03e-02	5.17e-03	2.18e-01
NOD1/2 Signaling Pathway	29	4.69e-01	6.20e-01	0.17400	-0.131000	-1.15e-01	2.22e-01	2.85e-01
Interleukin-2 signaling	11	6.98e-01	7.97e-01	0.17400	0.096700	1.45e-01	5.79e-01	4.07e-01
PD-1 signaling	21	5.89e-01	7.15e-01	0.17400	0.125000	1.20e-01	3.20e-01	3.40e-01
Signaling by KIT in disease	20	3.42e-01	5.16e-01	0.17300	-0.160000	-6.66e-02	2.15e-01	6.06e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	3.42e-01	5.16e-01	0.17300	-0.160000	-6.66e-02	2.15e-01	6.06e-01
Recruitment of NuMA to mitotic centrosomes	75	1.15e-01	2.75e-01	0.17300	-0.138000	-1.04e-01	3.81e-02	1.19e-01
Peptide hormone metabolism	83	7.37e-02	2.09e-01	0.17300	-0.143000	-9.80e-02	2.46e-02	1.23e-01
Cyclin A/B1/B2 associated events during G2/M transition	24	1.11e-01	2.70e-01	0.17300	-0.027600	-1.70e-01	8.15e-01	1.48e-01
Loss of Nlp from mitotic centrosomes	65	1.92e-01	3.75e-01	0.17200	-0.113000	-1.29e-01	1.15e-01	7.14e-02
Loss of proteins required for interphase microtubule organization from the centrosome	65	1.92e-01	3.75e-01	0.17200	-0.113000	-1.29e-01	1.15e-01	7.14e-02
Interaction between L1 and Ankyrins	28	4.96e-01	6.41e-01	0.17200	-0.115000	-1.27e-01	2.92e-01	2.44e-01
Interferon alpha/beta signaling	69	4.80e-02	1.53e-01	0.17100	0.154000	7.61e-02	2.73e-02	2.74e-01
ESR-mediated signaling	160	3.31e-03	1.98e-02	0.17100	-0.147000	-8.79e-02	1.32e-03	5.49e-02
PCNA-Dependent Long Patch Base Excision Repair	21	1.52e-01	3.33e-01	0.17100	-0.027600	-1.69e-01	8.27e-01	1.80e-01
SARS-CoV-2 modulates autophagy	11	7.61e-01	8.40e-01	0.17100	-0.115000	-1.27e-01	5.10e-01	4.67e-01
Synaptic adhesion-like molecules	19	6.06e-01	7.25e-01	0.17000	-0.107000	-1.33e-01	4.18e-01	3.17e-01
Muscle contraction	193	5.90e-05	7.02e-04	0.17000	-0.157000	-6.67e-02	1.70e-04	1.10e-01
Nucleotide biosynthesis	14	3.33e-01	5.10e-01	0.17000	-0.037400	-1.66e-01	8.09e-01	2.82e-01
Phosphorylation of the APC/C	20	4.16e-01	5.72e-01	0.17000	0.153000	7.49e-02	2.37e-01	5.62e-01
IRS-related events triggered by IGF1R	50	1.23e-01	2.87e-01	0.17000	-0.151000	-7.73e-02	6.43e-02	3.44e-01
Signaling by ERBB2 TMD/JMD mutants	21	5.91e-01	7.15e-01	0.17000	-0.129000	-1.10e-01	3.07e-01	3.81e-01
Cytochrome c-mediated apoptotic response	12	3.92e-01	5.52e-01	0.16900	0.165000	3.66e-02	3.21e-01	8.26e-01
MAP2K and MAPK activation	36	2.44e-01	4.31e-01	0.16900	-0.149000	-8.04e-02	1.22e-01	4.04e-01
Ion transport by P-type ATPases	51	1.70e-02	7.23e-02	0.16900	-0.165000	-3.42e-02	4.11e-02	6.73e-01
Activation of the AP-1 family of transcription factors	10	4.44e-01	5.98e-01	0.16900	-0.033000	-1.66e-01	8.57e-01	3.65e-01
Negative regulation of FLT3	15	7.00e-01	7.97e-01	0.16900	0.119000	1.20e-01	4.26e-01	4.21e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	5.16e-01	6.58e-01	0.16900	0.080400	1.48e-01	5.66e-01	2.89e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	1.54e-01	3.34e-01	0.16800	-0.153000	-7.09e-02	9.03e-02	4.32e-01
Signaling by RAS mutants	41	1.54e-01	3.34e-01	0.16800	-0.153000	-7.09e-02	9.03e-02	4.32e-01
Signaling by moderate kinase activity BRAF mutants	41	1.54e-01	3.34e-01	0.16800	-0.153000	-7.09e-02	9.03e-02	4.32e-01
Signaling downstream of RAS mutants	41	1.54e-01	3.34e-01	0.16800	-0.153000	-7.09e-02	9.03e-02	4.32e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	7.63e-01	8.41e-01	0.16800	-0.127000	-1.10e-01	4.65e-01	5.27e-01
GPCR downstream signalling	603	3.93e-15	8.67e-13	0.16800	-0.158000	-5.78e-02	3.28e-11	1.51e-02
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	7.37e-01	8.26e-01	0.16800	-0.135000	-9.96e-02	4.37e-01	5.67e-01
HSF1-dependent transactivation	35	2.30e-01	4.16e-01	0.16800	0.074600	1.50e-01	4.45e-01	1.25e-01
FOXO-mediated transcription of cell death genes	15	7.02e-01	7.99e-01	0.16700	0.114000	1.22e-01	4.45e-01	4.12e-01
Clathrin-mediated endocytosis	135	4.09e-02	1.38e-01	0.16700	-0.124000	-1.12e-01	1.27e-02	2.47e-02
Nuclear signaling by ERBB4	32	3.52e-01	5.24e-01	0.16700	-0.142000	-8.82e-02	1.65e-01	3.88e-01
NCAM signaling for neurite out-growth	57	1.03e-02	4.86e-02	0.16700	-0.164000	-3.17e-02	3.22e-02	6.79e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	1.71e-01	3.54e-01	0.16700	0.062300	-1.54e-01	7.33e-01	3.98e-01
Insulin receptor recycling	26	5.03e-01	6.47e-01	0.16700	-0.101000	-1.33e-01	3.73e-01	2.42e-01
IGF1R signaling cascade	51	1.12e-01	2.70e-01	0.16700	-0.150000	-7.20e-02	6.36e-02	3.73e-01
Translation of Structural Proteins 9694635	55	2.58e-01	4.43e-01	0.16600	-0.128000	-1.05e-01	9.99e-02	1.76e-01
Platelet degranulation	115	6.95e-02	2.01e-01	0.16600	-0.122000	-1.12e-01	2.36e-02	3.77e-02
Leishmania infection	156	5.80e-04	4.63e-03	0.16600	-0.152000	-6.48e-02	1.01e-03	1.62e-01
Transcription of the HIV genome	62	1.47e-01	3.26e-01	0.16600	0.139000	8.96e-02	5.77e-02	2.22e-01
Intracellular signaling by second messengers	313	5.42e-05	6.65e-04	0.16500	-0.140000	-8.78e-02	1.98e-05	7.49e-03
Formation of tubulin folding intermediates by CCT/TriC	26	9.00e-02	2.37e-01	0.16500	0.164000	1.81e-02	1.47e-01	8.73e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	52	9.81e-02	2.52e-01	0.16500	-0.150000	-6.84e-02	6.07e-02	3.94e-01
Signaling by FGFR1 in disease	37	1.15e-01	2.75e-01	0.16500	-0.156000	-5.19e-02	9.94e-02	5.84e-01
Formation of TC-NER Pre-Incision Complex	51	2.35e-01	4.21e-01	0.16500	0.136000	9.34e-02	9.37e-02	2.48e-01
IRS-mediated signalling	47	1.88e-01	3.72e-01	0.16400	-0.143000	-7.94e-02	8.95e-02	3.46e-01
Polymerase switching on the C-strand of the telomere	24	9.78e-02	2.51e-01	0.16400	-0.012100	-1.63e-01	9.19e-01	1.67e-01
CLEC7A (Dectin-1) signaling	96	4.72e-02	1.52e-01	0.16300	0.084800	1.39e-01	1.51e-01	1.83e-02
Class B/2 (Secretin family receptors)	94	9.44e-02	2.44e-01	0.16300	-0.129000	-9.89e-02	3.00e-02	9.73e-02
Centrosome maturation	76	1.58e-01	3.38e-01	0.16200	-0.127000	-9.99e-02	5.48e-02	1.32e-01
Recruitment of mitotic centrosome proteins and complexes	76	1.58e-01	3.38e-01	0.16200	-0.127000	-9.99e-02	5.48e-02	1.32e-01
Interleukin-35 Signalling	12	7.33e-01	8.22e-01	0.16200	-0.131000	-9.51e-02	4.33e-01	5.68e-01
TP53 Regulates Transcription of DNA Repair Genes	57	1.80e-01	3.64e-01	0.16100	0.136000	8.56e-02	7.46e-02	2.64e-01
NCAM1 interactions	36	2.16e-02	8.70e-02	0.16100	-0.161000	2.18e-04	9.46e-02	9.98e-01
Signaling by ERBB2	49	5.56e-02	1.70e-01	0.16000	-0.154000	-4.64e-02	6.28e-02	5.74e-01
Formation of HIV elongation complex in the absence of HIV Tat	40	3.32e-01	5.08e-01	0.16000	0.133000	8.95e-02	1.46e-01	3.27e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	49	3.50e-01	5.24e-01	0.16000	-0.115000	-1.12e-01	1.64e-01	1.76e-01
Glycogen metabolism	22	5.81e-01	7.07e-01	0.16000	-0.096300	-1.28e-01	4.34e-01	2.99e-01
Growth hormone receptor signaling	24	5.40e-01	6.76e-01	0.16000	-0.093100	-1.30e-01	4.30e-01	2.71e-01
Synthesis of glycosylphosphatidylinositol (GPI)	17	6.96e-01	7.97e-01	0.16000	-0.115000	-1.11e-01	4.12e-01	4.29e-01
Metabolism of carbohydrates	275	1.23e-03	8.64e-03	0.15900	-0.128000	-9.55e-02	2.63e-04	6.38e-03
tRNA processing in the nucleus	55	4.83e-02	1.54e-01	0.15900	0.151000	4.95e-02	5.20e-02	5.25e-01
Common Pathway of Fibrin Clot Formation	21	3.50e-02	1.24e-01	0.15900	-0.148000	5.78e-02	2.40e-01	6.47e-01
Negative regulation of FGFR1 signaling	32	4.68e-01	6.20e-01	0.15800	0.126000	9.61e-02	2.19e-01	3.47e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	4.99e-01	6.44e-01	0.15800	-0.150000	-4.99e-02	3.50e-01	7.55e-01
Diseases associated with the TLR signaling cascade	29	4.59e-01	6.13e-01	0.15700	-0.131000	-8.72e-02	2.23e-01	4.16e-01
Diseases of Immune System	29	4.59e-01	6.13e-01	0.15700	-0.131000	-8.72e-02	2.23e-01	4.16e-01
Trafficking and processing of endosomal TLR	11	5.49e-01	6.82e-01	0.15700	0.047800	1.50e-01	7.84e-01	3.90e-01
MyD88 deficiency (TLR2/4)	16	1.58e-01	3.38e-01	0.15700	-0.156000	1.38e-02	2.79e-01	9.24e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	117	9.04e-02	2.38e-01	0.15700	-0.113000	-1.09e-01	3.44e-02	4.20e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex	15	3.48e-01	5.22e-01	0.15600	0.030000	1.54e-01	8.40e-01	3.03e-01
KEAP1-NFE2L2 pathway	103	1.08e-01	2.65e-01	0.15600	0.100000	1.20e-01	7.81e-02	3.55e-02
IL-6-type cytokine receptor ligand interactions	17	2.14e-01	3.96e-01	0.15600	-0.156000	-9.31e-03	2.65e-01	9.47e-01
SARS-CoV-1 activates/modulates innate immune responses	37	4.72e-01	6.22e-01	0.15600	0.111000	1.10e-01	2.43e-01	2.47e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	38	4.27e-01	5.83e-01	0.15600	0.122000	9.63e-02	1.92e-01	3.04e-01
HIV Transcription Elongation	38	4.27e-01	5.83e-01	0.15600	0.122000	9.63e-02	1.92e-01	3.04e-01
Tat-mediated elongation of the HIV-1 transcript	38	4.27e-01	5.83e-01	0.15600	0.122000	9.63e-02	1.92e-01	3.04e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	54	2.04e-01	3.86e-01	0.15600	-0.133000	-8.01e-02	8.99e-02	3.08e-01
HSF1 activation	27	1.87e-01	3.71e-01	0.15500	0.151000	3.75e-02	1.75e-01	7.36e-01
Ethanol oxidation	12	7.09e-01	8.05e-01	0.15500	0.081100	1.32e-01	6.27e-01	4.28e-01
RNA Polymerase II Pre-transcription Events	73	1.51e-01	3.31e-01	0.15500	0.129000	8.60e-02	5.71e-02	2.04e-01
Acetylcholine binding and downstream events	14	7.44e-01	8.29e-01	0.15500	0.099400	1.18e-01	5.20e-01	4.43e-01
Postsynaptic nicotinic acetylcholine receptors	14	7.44e-01	8.29e-01	0.15500	0.099400	1.18e-01	5.20e-01	4.43e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	30	4.71e-01	6.22e-01	0.15500	-0.127000	-8.77e-02	2.27e-01	4.06e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	5.95e-01	7.18e-01	0.15400	0.085500	1.29e-01	5.08e-01	3.19e-01
Listeria monocytogenes entry into host cells	19	6.68e-01	7.73e-01	0.15400	-0.119000	-9.85e-02	3.70e-01	4.57e-01
Glucagon-type ligand receptors	33	1.91e-01	3.75e-01	0.15400	-0.146000	-4.97e-02	1.47e-01	6.22e-01
Signaling by Insulin receptor	77	1.46e-01	3.25e-01	0.15400	-0.127000	-8.71e-02	5.38e-02	1.86e-01
DNA Damage/Telomere Stress Induced Senescence	28	5.59e-01	6.90e-01	0.15400	-0.117000	-9.94e-02	2.83e-01	3.63e-01
Translation of Structural Proteins 9683701	29	4.94e-01	6.40e-01	0.15300	-0.087800	-1.26e-01	4.13e-01	2.41e-01
Response to elevated platelet cytosolic Ca2+	120	8.85e-02	2.36e-01	0.15300	-0.115000	-1.01e-01	2.89e-02	5.64e-02
Transcriptional Regulation by NPAS4	33	2.30e-01	4.16e-01	0.15300	-0.143000	-5.52e-02	1.56e-01	5.83e-01
Regulated proteolysis of p75NTR	11	1.77e-01	3.60e-01	0.15300	0.068600	-1.37e-01	6.94e-01	4.33e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	38	4.63e-01	6.17e-01	0.15300	-0.100000	-1.15e-01	2.86e-01	2.18e-01
Surfactant metabolism	28	1.40e-01	3.15e-01	0.15300	-0.151000	-2.61e-02	1.68e-01	8.11e-01
Metabolism of water-soluble vitamins and cofactors	118	8.40e-02	2.27e-01	0.15300	-0.096100	-1.19e-01	7.12e-02	2.61e-02
Host Interactions of HIV factors	122	8.97e-02	2.37e-01	0.15300	0.113000	1.02e-01	3.04e-02	5.14e-02
Frs2-mediated activation	12	7.76e-01	8.49e-01	0.15200	-0.119000	-9.56e-02	4.77e-01	5.66e-01
Drug ADME	104	1.32e-01	3.00e-01	0.15200	-0.112000	-1.04e-01	4.90e-02	6.80e-02
TRAF6 mediated IRF7 activation	26	2.11e-01	3.93e-01	0.15200	0.148000	3.62e-02	1.92e-01	7.49e-01
Insulin receptor signalling cascade	53	1.00e-01	2.53e-01	0.15200	-0.141000	-5.55e-02	7.47e-02	4.85e-01
ABC-family proteins mediated transport	98	1.52e-01	3.33e-01	0.15200	0.106000	1.09e-01	6.97e-02	6.26e-02
Vpr-mediated nuclear import of PICs	32	3.06e-01	4.84e-01	0.15200	-0.063600	-1.38e-01	5.33e-01	1.78e-01
COPI-mediated anterograde transport	83	4.43e-02	1.45e-01	0.15100	-0.062300	-1.38e-01	3.26e-01	3.00e-02
Organic cation/anion/zwitterion transport	15	9.08e-02	2.38e-01	0.15100	-0.129000	7.86e-02	3.87e-01	5.98e-01
Peptide hormone biosynthesis	11	3.90e-01	5.52e-01	0.15100	-0.151000	-7.92e-03	3.87e-01	9.64e-01
Tight junction interactions	28	2.63e-01	4.48e-01	0.15100	-0.143000	-4.88e-02	1.92e-01	6.55e-01
Processing of Intronless Pre-mRNAs	19	4.71e-01	6.22e-01	0.15100	-0.058900	-1.39e-01	6.57e-01	2.96e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	7.27e-01	8.19e-01	0.15100	-0.092300	-1.19e-01	5.36e-01	4.25e-01
IRAK4 deficiency (TLR2/4)	17	2.83e-01	4.67e-01	0.15000	-0.149000	-1.90e-02	2.87e-01	8.92e-01
Signaling by GPCR	670	3.20e-13	4.12e-11	0.15000	-0.140000	-5.21e-02	5.47e-10	2.11e-02
Regulation of gene expression by Hypoxia-inducible Factor	11	7.65e-01	8.42e-01	0.15000	-0.125000	-8.28e-02	4.74e-01	6.34e-01
Mitotic Prometaphase	174	2.75e-02	1.05e-01	0.14900	-0.091600	-1.18e-01	3.69e-02	7.36e-03
Hedgehog ‘off’ state	97	1.18e-01	2.79e-01	0.14900	0.087600	1.21e-01	1.36e-01	3.99e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	3.69e-01	5.36e-01	0.14900	0.008340	1.49e-01	9.60e-01	3.72e-01
Diseases of signal transduction by growth factor receptors and second messengers	410	4.34e-05	5.64e-04	0.14900	-0.125000	-8.09e-02	1.36e-05	4.88e-03
G0 and Early G1	27	3.41e-01	5.15e-01	0.14800	-0.056000	-1.37e-01	6.15e-01	2.17e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	4.65e-02	1.50e-01	0.14800	0.147000	-2.04e-02	1.79e-01	8.52e-01
Cell surface interactions at the vascular wall	127	9.19e-03	4.47e-02	0.14800	-0.135000	-5.96e-02	8.36e-03	2.46e-01
FCGR activation	12	3.00e-01	4.84e-01	0.14800	-0.011000	1.47e-01	9.48e-01	3.77e-01
Signaling by NOTCH3	48	3.86e-01	5.48e-01	0.14700	0.092100	1.15e-01	2.69e-01	1.68e-01
Ribavirin ADME	11	7.95e-01	8.61e-01	0.14700	-0.088100	-1.18e-01	6.13e-01	4.99e-01
Transcriptional Regulation by VENTX	41	5.03e-02	1.58e-01	0.14700	-0.146000	-1.61e-02	1.06e-01	8.59e-01
Sensory Perception	570	4.34e-05	5.64e-04	0.14700	-0.101000	-1.06e-01	3.43e-05	1.46e-05
Diseases associated with glycosylation precursor biosynthesis	15	1.69e-01	3.52e-01	0.14700	0.143000	-3.25e-02	3.38e-01	8.28e-01
Basigin interactions	24	5.22e-01	6.62e-01	0.14600	-0.126000	-7.32e-02	2.83e-01	5.35e-01
Incretin synthesis, secretion, and inactivation	23	7.04e-02	2.02e-01	0.14600	-0.143000	2.99e-02	2.35e-01	8.04e-01
BBSome-mediated cargo-targeting to cilium	23	6.01e-01	7.21e-01	0.14600	0.120000	8.32e-02	3.20e-01	4.90e-01
mRNA Editing	10	7.99e-01	8.63e-01	0.14600	0.082100	1.20e-01	6.53e-01	5.10e-01
Constitutive Signaling by Aberrant PI3K in Cancer	77	1.61e-01	3.43e-01	0.14500	-0.122000	-7.85e-02	6.41e-02	2.33e-01
Serotonin receptors	11	4.29e-01	5.84e-01	0.14500	-0.145000	-9.76e-03	4.06e-01	9.55e-01
Interleukin-1 signaling	109	1.10e-01	2.68e-01	0.14500	0.086400	1.16e-01	1.19e-01	3.64e-02
Meiotic recombination	26	2.64e-01	4.49e-01	0.14400	-0.037600	-1.39e-01	7.40e-01	2.19e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	106	1.01e-01	2.53e-01	0.14400	-0.119000	-8.20e-02	3.47e-02	1.44e-01
Toll Like Receptor 2 (TLR2) Cascade	106	1.01e-01	2.53e-01	0.14400	-0.119000	-8.20e-02	3.47e-02	1.44e-01
Toll Like Receptor TLR1:TLR2 Cascade	106	1.01e-01	2.53e-01	0.14400	-0.119000	-8.20e-02	3.47e-02	1.44e-01
Toll Like Receptor TLR6:TLR2 Cascade	106	1.01e-01	2.53e-01	0.14400	-0.119000	-8.20e-02	3.47e-02	1.44e-01
Mitochondrial biogenesis	69	3.01e-01	4.84e-01	0.14400	-0.104000	-9.95e-02	1.34e-01	1.53e-01
Metabolic disorders of biological oxidation enzymes	32	5.67e-01	6.97e-01	0.14400	-0.095700	-1.08e-01	3.49e-01	2.92e-01
G1/S Transition	126	8.56e-02	2.29e-01	0.14400	0.114000	8.76e-02	2.68e-02	8.95e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	25	5.98e-02	1.80e-01	0.14400	0.030300	-1.41e-01	7.93e-01	2.24e-01
Creation of C4 and C2 activators	14	1.51e-01	3.31e-01	0.14300	-0.059500	1.30e-01	7.00e-01	3.98e-01
TBC/RABGAPs	42	4.74e-01	6.23e-01	0.14300	-0.108000	-9.35e-02	2.25e-01	2.94e-01
Asparagine N-linked glycosylation	278	9.26e-04	6.98e-03	0.14300	-0.072700	-1.23e-01	3.67e-02	4.04e-04
Interleukin-2 family signaling	40	3.43e-01	5.16e-01	0.14300	-0.125000	-7.01e-02	1.73e-01	4.43e-01
Glyoxylate metabolism and glycine degradation	30	2.56e-01	4.41e-01	0.14300	-0.043100	-1.36e-01	6.83e-01	1.96e-01
Formation of RNA Pol II elongation complex	53	3.52e-01	5.24e-01	0.14300	0.114000	8.53e-02	1.50e-01	2.82e-01
RNA Polymerase II Transcription Elongation	53	3.52e-01	5.24e-01	0.14300	0.114000	8.53e-02	1.50e-01	2.82e-01
Visual phototransduction	93	4.32e-02	1.43e-01	0.14300	-0.130000	-5.82e-02	3.00e-02	3.32e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	32	8.59e-02	2.30e-01	0.14200	0.142000	6.91e-03	1.64e-01	9.46e-01
Early SARS-CoV-2 Infection Events	34	5.44e-01	6.78e-01	0.14200	-0.109000	-9.15e-02	2.71e-01	3.56e-01
Regulated Necrosis	53	2.52e-01	4.38e-01	0.14200	0.124000	7.05e-02	1.20e-01	3.74e-01
SUMOylation of immune response proteins	10	6.77e-01	7.80e-01	0.14200	0.133000	5.05e-02	4.67e-01	7.82e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	34	9.28e-03	4.50e-02	0.14200	0.068100	-1.24e-01	4.92e-01	2.10e-01
Adrenaline,noradrenaline inhibits insulin secretion	28	3.70e-01	5.36e-01	0.14200	-0.131000	-5.48e-02	2.32e-01	6.16e-01
Translesion synthesis by POLK	17	3.51e-01	5.24e-01	0.14100	-0.022300	-1.40e-01	8.74e-01	3.19e-01
Nuclear Pore Complex (NPC) Disassembly	34	2.94e-01	4.78e-01	0.14100	-0.053700	-1.31e-01	5.88e-01	1.87e-01
PIP3 activates AKT signaling	275	4.95e-03	2.75e-02	0.14100	-0.113000	-8.34e-02	1.19e-03	1.72e-02
Interactions of Vpr with host cellular proteins	33	3.11e-01	4.89e-01	0.14100	-0.053800	-1.30e-01	5.93e-01	1.97e-01
Chylomicron remodeling	10	4.30e-01	5.84e-01	0.14000	0.003800	-1.40e-01	9.83e-01	4.42e-01
RHO GTPase Effectors	232	8.73e-03	4.29e-02	0.14000	-0.115000	-7.95e-02	2.44e-03	3.69e-02
Pyruvate metabolism and Citric Acid (TCA) cycle	52	2.14e-01	3.97e-01	0.13900	-0.061100	-1.25e-01	4.45e-01	1.18e-01
TP53 Regulates Transcription of Cell Cycle Genes	49	9.39e-02	2.44e-01	0.13900	-0.035600	-1.35e-01	6.67e-01	1.03e-01
Triglyceride catabolism	23	6.85e-01	7.85e-01	0.13900	-0.103000	-9.42e-02	3.94e-01	4.34e-01
Signaling by EGFR	49	4.15e-01	5.72e-01	0.13900	-0.109000	-8.55e-02	1.85e-01	3.01e-01
Intra-Golgi traffic	43	3.46e-01	5.20e-01	0.13900	-0.120000	-6.91e-02	1.72e-01	4.33e-01
SUMOylation of RNA binding proteins	45	1.79e-01	3.63e-01	0.13900	-0.047800	-1.30e-01	5.79e-01	1.31e-01
Metabolism of amino acids and derivatives	344	1.88e-03	1.26e-02	0.13900	0.111000	8.34e-02	4.09e-04	7.81e-03
ER Quality Control Compartment (ERQC)	20	1.00e-01	2.53e-01	0.13900	0.132000	-4.17e-02	3.06e-01	7.47e-01
Protein methylation	16	6.99e-01	7.97e-01	0.13800	-0.073200	-1.17e-01	6.12e-01	4.16e-01
Metabolism of nucleotides	95	2.20e-01	4.05e-01	0.13800	-0.095700	-9.96e-02	1.07e-01	9.33e-02
Metalloprotease DUBs	19	7.17e-01	8.10e-01	0.13800	-0.085900	-1.08e-01	5.17e-01	4.14e-01
Constitutive Signaling by EGFRvIII	15	6.60e-01	7.66e-01	0.13800	-0.062900	-1.23e-01	6.73e-01	4.10e-01
Signaling by EGFRvIII in Cancer	15	6.60e-01	7.66e-01	0.13800	-0.062900	-1.23e-01	6.73e-01	4.10e-01
Signaling by ERBB2 in Cancer	25	6.76e-01	7.79e-01	0.13700	-0.095300	-9.83e-02	4.09e-01	3.95e-01
Killing mechanisms	11	3.06e-01	4.84e-01	0.13700	-0.036000	1.32e-01	8.36e-01	4.49e-01
WNT5:FZD7-mediated leishmania damping	11	3.06e-01	4.84e-01	0.13700	-0.036000	1.32e-01	8.36e-01	4.49e-01
The NLRP3 inflammasome	16	3.99e-01	5.60e-01	0.13600	-0.021200	-1.34e-01	8.83e-01	3.52e-01
Nonhomologous End-Joining (NHEJ)	32	1.69e-01	3.52e-01	0.13600	-0.023200	-1.34e-01	8.20e-01	1.89e-01
Epigenetic regulation of gene expression	83	2.02e-01	3.86e-01	0.13600	-0.077000	-1.12e-01	2.25e-01	7.81e-02
LGI-ADAM interactions	14	3.85e-01	5.48e-01	0.13500	-0.008130	-1.35e-01	9.58e-01	3.81e-01
Zinc transporters	17	1.28e-01	2.93e-01	0.13500	0.057000	-1.23e-01	6.84e-01	3.81e-01
Costimulation by the CD28 family	65	1.28e-01	2.93e-01	0.13500	-0.124000	-5.35e-02	8.29e-02	4.56e-01
Transcriptional regulation of testis differentiation	12	1.99e-01	3.85e-01	0.13500	-0.102000	8.90e-02	5.41e-01	5.94e-01
PI3K Cascade	43	2.95e-01	4.78e-01	0.13500	-0.122000	-5.85e-02	1.66e-01	5.07e-01
Extension of Telomeres	48	2.47e-01	4.33e-01	0.13500	-0.057200	-1.22e-01	4.93e-01	1.42e-01
Formation of the beta-catenin:TCF transactivating complex	32	4.03e-02	1.37e-01	0.13500	-0.132000	2.94e-02	1.96e-01	7.73e-01
G2/M Checkpoints	129	2.09e-02	8.47e-02	0.13500	0.123000	5.56e-02	1.57e-02	2.75e-01
Regulation of PLK1 Activity at G2/M Transition	83	2.29e-01	4.15e-01	0.13500	-0.080200	-1.09e-01	2.07e-01	8.73e-02
Resolution of Sister Chromatid Cohesion	98	8.35e-02	2.26e-01	0.13500	-0.063000	-1.19e-01	2.81e-01	4.16e-02
Autophagy	125	8.65e-02	2.31e-01	0.13500	-0.074700	-1.12e-01	1.49e-01	3.05e-02
MAP kinase activation	58	3.58e-01	5.27e-01	0.13500	-0.108000	-7.99e-02	1.53e-01	2.92e-01
Azathioprine ADME	22	6.67e-01	7.73e-01	0.13400	-0.110000	-7.75e-02	3.73e-01	5.29e-01
Maturation of nucleoprotein 9683610	11	5.98e-01	7.18e-01	0.13400	-0.031700	-1.30e-01	8.55e-01	4.54e-01
Mitochondrial calcium ion transport	22	7.18e-01	8.10e-01	0.13400	-0.096600	-9.30e-02	4.33e-01	4.50e-01
Interleukin-27 signaling	11	7.21e-01	8.12e-01	0.13400	-0.122000	-5.46e-02	4.84e-01	7.54e-01
Regulation of TP53 Activity	154	1.02e-01	2.56e-01	0.13300	-0.091600	-9.68e-02	4.97e-02	3.79e-02
Signaling by ERBB2 ECD mutants	15	7.74e-01	8.48e-01	0.13300	-0.106000	-8.02e-02	4.75e-01	5.91e-01
Deadenylation-dependent mRNA decay	56	1.53e-01	3.34e-01	0.13300	-0.048300	-1.24e-01	5.32e-01	1.08e-01
RA biosynthesis pathway	22	6.42e-01	7.51e-01	0.13300	-0.071600	-1.12e-01	5.61e-01	3.62e-01
Pyroptosis	26	4.66e-01	6.20e-01	0.13300	-0.054000	-1.21e-01	6.33e-01	2.85e-01
Organelle biogenesis and maintenance	243	3.01e-02	1.12e-01	0.13200	-0.092400	-9.43e-02	1.31e-02	1.13e-02
Signaling by TGFB family members	118	1.64e-01	3.46e-01	0.13200	-0.101000	-8.48e-02	5.79e-02	1.11e-01
RNA Polymerase III Chain Elongation	18	2.42e-01	4.29e-01	0.13200	0.131000	-8.87e-03	3.34e-01	9.48e-01
Unwinding of DNA	12	6.40e-01	7.51e-01	0.13200	0.125000	4.16e-02	4.54e-01	8.03e-01
Macroautophagy	111	1.20e-01	2.82e-01	0.13100	-0.071400	-1.10e-01	1.94e-01	4.55e-02
Signaling by Activin	15	8.05e-01	8.66e-01	0.13100	0.088500	9.64e-02	5.53e-01	5.18e-01
AURKA Activation by TPX2	68	3.51e-01	5.24e-01	0.13100	-0.082700	-1.01e-01	2.38e-01	1.48e-01
Cytosolic iron-sulfur cluster assembly	10	3.10e-01	4.88e-01	0.12900	0.111000	-6.67e-02	5.44e-01	7.15e-01
Deactivation of the beta-catenin transactivating complex	39	4.77e-02	1.53e-01	0.12900	-0.129000	1.14e-02	1.64e-01	9.02e-01
Gap junction trafficking and regulation	29	6.58e-01	7.65e-01	0.12900	-0.097500	-8.47e-02	3.64e-01	4.30e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	7.38e-01	8.26e-01	0.12900	0.105000	7.42e-02	4.40e-01	5.86e-01
Formation of the Early Elongation Complex	32	5.96e-01	7.18e-01	0.12800	0.103000	7.53e-02	3.12e-01	4.61e-01
Formation of the HIV-1 Early Elongation Complex	32	5.96e-01	7.18e-01	0.12800	0.103000	7.53e-02	3.12e-01	4.61e-01
Rev-mediated nuclear export of HIV RNA	33	2.53e-01	4.38e-01	0.12800	-0.031100	-1.24e-01	7.58e-01	2.18e-01
Nucleotide catabolism	35	5.96e-01	7.18e-01	0.12700	-0.099300	-7.98e-02	3.09e-01	4.14e-01
Activation of HOX genes during differentiation	61	2.86e-01	4.70e-01	0.12700	-0.110000	-6.39e-02	1.37e-01	3.88e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	61	2.86e-01	4.70e-01	0.12700	-0.110000	-6.39e-02	1.37e-01	3.88e-01
Activation of Matrix Metalloproteinases	31	6.31e-01	7.44e-01	0.12700	-0.079200	-9.96e-02	4.45e-01	3.37e-01
Downregulation of TGF-beta receptor signaling	26	6.57e-01	7.65e-01	0.12700	-0.103000	-7.45e-02	3.63e-01	5.11e-01
G2/M DNA damage checkpoint	58	4.24e-02	1.41e-01	0.12700	-0.014200	-1.26e-01	8.52e-01	9.61e-02
ERKs are inactivated	13	8.33e-01	8.84e-01	0.12700	0.082900	9.63e-02	6.05e-01	5.48e-01
Pre-NOTCH Transcription and Translation	45	2.73e-02	1.04e-01	0.12700	-0.126000	1.69e-02	1.44e-01	8.44e-01
Cellular Senescence	130	1.59e-01	3.40e-01	0.12700	-0.097100	-8.14e-02	5.59e-02	1.09e-01
Cilium Assembly	174	9.83e-02	2.52e-01	0.12600	-0.087100	-9.17e-02	4.74e-02	3.68e-02
Organic anion transporters	10	5.23e-01	6.62e-01	0.12600	0.000770	1.26e-01	9.97e-01	4.89e-01
MyD88 cascade initiated on plasma membrane	91	2.92e-01	4.77e-01	0.12600	-0.093600	-8.46e-02	1.23e-01	1.63e-01
Toll Like Receptor 10 (TLR10) Cascade	91	2.92e-01	4.77e-01	0.12600	-0.093600	-8.46e-02	1.23e-01	1.63e-01
Toll Like Receptor 5 (TLR5) Cascade	91	2.92e-01	4.77e-01	0.12600	-0.093600	-8.46e-02	1.23e-01	1.63e-01
TNFR1-induced NFkappaB signaling pathway	22	6.82e-01	7.84e-01	0.12600	0.069400	1.05e-01	5.73e-01	3.94e-01
Cargo recognition for clathrin-mediated endocytosis	98	2.51e-01	4.38e-01	0.12600	-0.079700	-9.71e-02	1.73e-01	9.65e-02
EML4 and NUDC in mitotic spindle formation	93	1.85e-01	3.70e-01	0.12600	-0.066900	-1.06e-01	2.65e-01	7.65e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	6.53e-01	7.62e-01	0.12500	0.111000	5.78e-02	4.01e-01	6.63e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	6.53e-01	7.62e-01	0.12500	0.111000	5.78e-02	4.01e-01	6.63e-01
DNA strand elongation	31	9.44e-02	2.44e-01	0.12500	0.014500	-1.24e-01	8.89e-01	2.31e-01
Signaling by FGFR3 in disease	21	6.52e-01	7.61e-01	0.12500	-0.109000	-6.15e-02	3.88e-01	6.26e-01
Transport of small molecules	689	5.27e-09	2.04e-07	0.12500	-0.116000	-4.72e-02	2.07e-07	3.41e-02
G alpha (i) signalling events	305	3.60e-06	8.69e-05	0.12500	-0.122000	-2.83e-02	2.52e-04	3.94e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	20	1.04e-01	2.59e-01	0.12500	-0.099900	7.50e-02	4.39e-01	5.62e-01
Cellular response to chemical stress	187	5.49e-02	1.69e-01	0.12500	0.072900	1.01e-01	8.54e-02	1.69e-02
Generation of second messenger molecules	30	1.75e-01	3.59e-01	0.12500	0.007060	1.25e-01	9.47e-01	2.38e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	5.84e-01	7.10e-01	0.12400	0.112000	5.30e-02	3.61e-01	6.67e-01
Metabolism of vitamins and cofactors	181	7.07e-02	2.02e-01	0.12400	-0.074700	-9.89e-02	8.29e-02	2.17e-02
Protein folding	96	1.15e-01	2.75e-01	0.12400	-0.055500	-1.10e-01	3.47e-01	6.15e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	4.62e-01	6.16e-01	0.12400	0.123000	-9.29e-03	4.79e-01	9.57e-01
Spry regulation of FGF signaling	16	6.34e-01	7.46e-01	0.12300	0.115000	4.54e-02	4.27e-01	7.53e-01
Calnexin/calreticulin cycle	25	6.21e-02	1.85e-01	0.12300	0.079800	-9.38e-02	4.90e-01	4.17e-01
Striated Muscle Contraction	33	6.61e-02	1.94e-01	0.12300	-0.120000	2.56e-02	2.31e-01	7.99e-01
Smooth Muscle Contraction	43	5.11e-02	1.60e-01	0.12300	-0.123000	9.09e-03	1.64e-01	9.18e-01
Peroxisomal protein import	62	4.41e-01	5.95e-01	0.12300	0.093700	7.91e-02	2.02e-01	2.81e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	14	5.06e-01	6.49e-01	0.12300	-0.016300	-1.21e-01	9.16e-01	4.31e-01
Post-translational protein modification	1289	2.15e-07	6.79e-06	0.12300	-0.086600	-8.66e-02	1.51e-07	1.50e-07
Signaling by ERBB4	57	4.67e-01	6.20e-01	0.12200	-0.094500	-7.76e-02	2.17e-01	3.11e-01
Acyl chain remodelling of PS	21	1.16e-01	2.75e-01	0.12200	-0.106000	6.06e-02	4.02e-01	6.31e-01
Chaperonin-mediated protein folding	90	9.25e-02	2.42e-01	0.12200	-0.046400	-1.12e-01	4.47e-01	6.54e-02
Signaling by NODAL	21	5.68e-01	6.98e-01	0.12100	0.045400	1.12e-01	7.18e-01	3.72e-01
Dissolution of Fibrin Clot	13	7.00e-01	7.97e-01	0.12100	0.044400	1.13e-01	7.81e-01	4.82e-01
Mitochondrial protein import	54	2.62e-01	4.48e-01	0.12100	0.111000	4.87e-02	1.59e-01	5.36e-01
Signaling by NTRKs	133	2.01e-01	3.86e-01	0.12100	-0.085000	-8.56e-02	9.05e-02	8.82e-02
mRNA Capping	28	4.61e-01	6.16e-01	0.12000	0.112000	4.35e-02	3.03e-01	6.90e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	41	2.36e-01	4.24e-01	0.12000	-0.032000	-1.16e-01	7.22e-01	1.98e-01
Regulation of beta-cell development	41	2.88e-02	1.08e-01	0.12000	-0.036000	1.15e-01	6.90e-01	2.03e-01
tRNA Aminoacylation	24	6.32e-01	7.45e-01	0.12000	-0.058400	-1.05e-01	6.20e-01	3.73e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	7.83e-01	8.53e-01	0.12000	0.088700	8.11e-02	4.92e-01	5.30e-01
Reproduction	82	2.76e-01	4.59e-01	0.12000	-0.100000	-6.65e-02	1.17e-01	2.98e-01
Phospholipase C-mediated cascade; FGFR3	12	6.40e-01	7.51e-01	0.12000	0.028700	1.16e-01	8.63e-01	4.85e-01
Phase 0 - rapid depolarisation	31	6.74e-01	7.79e-01	0.12000	-0.092100	-7.68e-02	3.75e-01	4.59e-01
FGFR2b ligand binding and activation	10	8.76e-01	9.12e-01	0.11900	0.094000	7.35e-02	6.07e-01	6.87e-01
Signal transduction by L1	20	4.15e-01	5.72e-01	0.11900	-0.118000	-1.87e-02	3.62e-01	8.85e-01
Separation of Sister Chromatids	161	9.92e-02	2.53e-01	0.11900	0.097200	6.91e-02	3.33e-02	1.30e-01
Metabolism of non-coding RNA	50	3.37e-02	1.21e-01	0.11900	0.013000	-1.18e-01	8.73e-01	1.49e-01
snRNP Assembly	50	3.37e-02	1.21e-01	0.11900	0.013000	-1.18e-01	8.73e-01	1.49e-01
Reduction of cytosolic Ca++ levels	11	7.52e-01	8.34e-01	0.11900	-0.110000	-4.43e-02	5.28e-01	7.99e-01
Interactions of Rev with host cellular proteins	35	1.54e-01	3.34e-01	0.11800	-0.005290	-1.18e-01	9.57e-01	2.26e-01
RNA Polymerase I Promoter Escape	28	7.17e-01	8.10e-01	0.11800	0.088100	7.83e-02	4.20e-01	4.73e-01
Regulation of TP53 Degradation	36	4.50e-01	6.03e-01	0.11800	-0.107000	-4.97e-02	2.68e-01	6.06e-01
Hyaluronan uptake and degradation	12	8.12e-01	8.71e-01	0.11800	-0.102000	-5.93e-02	5.43e-01	7.22e-01
DAP12 signaling	28	3.01e-01	4.84e-01	0.11700	-0.116000	-1.76e-02	2.89e-01	8.72e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	95	2.69e-01	4.54e-01	0.11700	-0.095200	-6.79e-02	1.09e-01	2.53e-01
S Phase	157	1.02e-01	2.56e-01	0.11700	0.096800	6.53e-02	3.63e-02	1.58e-01
Synthesis of substrates in N-glycan biosythesis	60	4.47e-01	6.00e-01	0.11600	-0.068500	-9.41e-02	3.59e-01	2.07e-01
Heme biosynthesis	13	7.98e-01	8.63e-01	0.11600	-0.057200	-1.01e-01	7.21e-01	5.29e-01
Arachidonic acid metabolism	56	4.80e-01	6.28e-01	0.11500	0.067300	9.30e-02	3.84e-01	2.29e-01
mRNA 3’-end processing	53	3.16e-01	4.95e-01	0.11500	0.105000	4.72e-02	1.88e-01	5.53e-01
Toll Like Receptor 4 (TLR4) Cascade	135	8.76e-02	2.34e-01	0.11500	-0.101000	-5.42e-02	4.26e-02	2.76e-01
Zinc influx into cells by the SLC39 gene family	10	3.93e-01	5.54e-01	0.11400	0.064000	-9.48e-02	7.26e-01	6.04e-01
ROS and RNS production in phagocytes	35	4.34e-01	5.88e-01	0.11400	-0.106000	-4.26e-02	2.79e-01	6.63e-01
HCMV Late Events	54	1.24e-01	2.88e-01	0.11400	-0.019400	-1.12e-01	8.05e-01	1.55e-01
FGFR2 alternative splicing	26	1.13e-01	2.71e-01	0.11300	0.103000	-4.65e-02	3.62e-01	6.81e-01
SARS-CoV-1 Infection	134	2.68e-02	1.04e-01	0.11300	0.107000	3.63e-02	3.20e-02	4.67e-01
Base-Excision Repair, AP Site Formation	18	7.77e-01	8.49e-01	0.11300	-0.062500	-9.43e-02	6.46e-01	4.88e-01
NGF-stimulated transcription	39	2.09e-01	3.91e-01	0.11300	0.112000	1.69e-02	2.27e-01	8.55e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	54	5.25e-01	6.62e-01	0.11300	-0.089200	-6.91e-02	2.57e-01	3.79e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	54	5.25e-01	6.62e-01	0.11300	-0.089200	-6.91e-02	2.57e-01	3.79e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	54	5.25e-01	6.62e-01	0.11300	-0.089200	-6.91e-02	2.57e-01	3.79e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	54	5.25e-01	6.62e-01	0.11300	-0.089200	-6.91e-02	2.57e-01	3.79e-01
Signaling by NOTCH1 in Cancer	54	5.25e-01	6.62e-01	0.11300	-0.089200	-6.91e-02	2.57e-01	3.79e-01
HIV Infection	216	3.55e-02	1.25e-01	0.11300	0.096800	5.79e-02	1.41e-02	1.42e-01
Peptide ligand-binding receptors	190	3.23e-02	1.18e-01	0.11300	0.051700	1.00e-01	2.19e-01	1.74e-02
Beta-oxidation of very long chain fatty acids	10	4.01e-01	5.61e-01	0.11300	-0.091000	6.62e-02	6.18e-01	7.17e-01
Diseases of programmed cell death	43	5.42e-01	6.76e-01	0.11300	0.094600	6.09e-02	2.83e-01	4.89e-01
B-WICH complex positively regulates rRNA expression	29	5.76e-01	7.04e-01	0.11200	0.101000	4.96e-02	3.48e-01	6.44e-01
FGFR2 mutant receptor activation	32	6.54e-01	7.62e-01	0.11200	0.092500	6.33e-02	3.65e-01	5.35e-01
MyD88 dependent cascade initiated on endosome	96	2.96e-01	4.79e-01	0.11200	-0.091300	-6.51e-02	1.22e-01	2.70e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	96	2.96e-01	4.79e-01	0.11200	-0.091300	-6.51e-02	1.22e-01	2.70e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	67	1.39e-01	3.14e-01	0.11200	0.108000	3.13e-02	1.28e-01	6.58e-01
Toll Like Receptor 9 (TLR9) Cascade	100	3.27e-01	5.04e-01	0.11200	-0.086400	-7.10e-02	1.35e-01	2.20e-01
Unfolded Protein Response (UPR)	90	3.84e-01	5.47e-01	0.11200	0.074400	8.33e-02	2.22e-01	1.72e-01
Cytosolic sensors of pathogen-associated DNA	60	2.16e-01	4.00e-01	0.11100	0.105000	3.61e-02	1.61e-01	6.29e-01
Translesion Synthesis by POLH	19	5.17e-01	6.58e-01	0.11100	0.108000	2.19e-02	4.13e-01	8.69e-01
RNA polymerase II transcribes snRNA genes	77	1.23e-01	2.86e-01	0.11100	0.105000	3.32e-02	1.09e-01	6.15e-01
Diseases of carbohydrate metabolism	30	5.22e-01	6.62e-01	0.11000	-0.102000	-4.24e-02	3.34e-01	6.87e-01
DNA Damage Bypass	46	8.42e-02	2.27e-01	0.11000	0.005550	-1.10e-01	9.48e-01	1.96e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	34	6.99e-01	7.97e-01	0.11000	-0.083200	-7.22e-02	4.01e-01	4.66e-01
TP53 Regulates Transcription of Cell Death Genes	42	5.11e-01	6.54e-01	0.11000	-0.096100	-5.37e-02	2.81e-01	5.47e-01
Retrograde neurotrophin signalling	14	8.20e-01	8.75e-01	0.11000	-0.093400	-5.81e-02	5.45e-01	7.06e-01
Interleukin-6 family signaling	24	5.51e-01	6.84e-01	0.11000	-0.104000	-3.65e-02	3.80e-01	7.57e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	3.04e-01	4.84e-01	0.11000	-0.053000	-9.61e-02	4.31e-01	1.53e-01
RNA Polymerase I Transcription Termination	27	7.53e-01	8.34e-01	0.11000	0.083500	7.10e-02	4.53e-01	5.23e-01
SLC-mediated transmembrane transport	238	1.09e-03	7.99e-03	0.10900	-0.105000	-2.92e-02	5.11e-03	4.38e-01
RUNX3 regulates p14-ARF	10	7.63e-01	8.40e-01	0.10900	-0.104000	-3.18e-02	5.68e-01	8.62e-01
Transport of the SLBP Dependant Mature mRNA	34	1.39e-01	3.14e-01	0.10900	0.013200	-1.08e-01	8.94e-01	2.75e-01
Activation of the pre-replicative complex	31	4.59e-01	6.13e-01	0.10900	-0.035000	-1.03e-01	7.36e-01	3.20e-01
Signaling by BMP	27	3.66e-01	5.32e-01	0.10900	-0.108000	-1.62e-02	3.33e-01	8.84e-01
Metallothioneins bind metals	11	5.91e-01	7.15e-01	0.10900	0.109000	1.11e-03	5.32e-01	9.95e-01
Toll-like Receptor Cascades	154	9.13e-02	2.39e-01	0.10800	-0.094800	-5.26e-02	4.22e-02	2.59e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	31	1.43e-01	3.20e-01	0.10800	0.106000	-2.11e-02	3.06e-01	8.39e-01
Passive transport by Aquaporins	13	8.02e-01	8.64e-01	0.10800	-0.096200	-4.91e-02	5.48e-01	7.59e-01
SHC-mediated cascade:FGFR4	19	8.30e-01	8.83e-01	0.10800	-0.079100	-7.31e-02	5.50e-01	5.81e-01
RHO GTPases Activate Formins	114	2.94e-01	4.77e-01	0.10800	-0.066300	-8.48e-02	2.22e-01	1.18e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	8.15e-01	8.72e-01	0.10800	-0.099200	-4.16e-02	5.87e-01	8.20e-01
Metabolism of steroids	148	1.66e-01	3.50e-01	0.10700	-0.088600	-6.06e-02	6.26e-02	2.03e-01
Transcription of E2F targets under negative control by DREAM complex	19	5.41e-01	6.76e-01	0.10700	-0.021700	-1.05e-01	8.70e-01	4.28e-01
Interconversion of nucleotide di- and triphosphates	29	6.24e-01	7.41e-01	0.10700	-0.049800	-9.50e-02	6.43e-01	3.76e-01
Processing of SMDT1	15	8.63e-01	9.07e-01	0.10700	-0.080000	-7.13e-02	5.92e-01	6.32e-01
Gene Silencing by RNA	80	1.40e-01	3.15e-01	0.10700	-0.102000	-3.37e-02	1.16e-01	6.03e-01
Synthesis, secretion, and deacylation of Ghrelin	19	7.35e-01	8.24e-01	0.10700	0.049400	9.47e-02	7.09e-01	4.75e-01
Expression and translocation of olfactory receptors	359	2.36e-04	2.19e-03	0.10700	-0.035000	-1.01e-01	2.53e-01	1.03e-03
Nuclear import of Rev protein	32	1.55e-01	3.34e-01	0.10700	0.017200	-1.05e-01	8.67e-01	3.03e-01
SUMOylation of transcription factors	20	5.20e-01	6.61e-01	0.10600	0.020200	1.05e-01	8.76e-01	4.18e-01
MHC class II antigen presentation	104	3.40e-01	5.14e-01	0.10600	-0.083300	-6.53e-02	1.42e-01	2.49e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	89	2.27e-01	4.13e-01	0.10600	-0.047200	-9.47e-02	4.42e-01	1.23e-01
Amplification of signal from the kinetochores	89	2.27e-01	4.13e-01	0.10600	-0.047200	-9.47e-02	4.42e-01	1.23e-01
Transport of Mature mRNA Derived from an Intronless Transcript	40	3.90e-01	5.52e-01	0.10500	-0.033800	-9.98e-02	7.12e-01	2.75e-01
Diseases of DNA repair	49	7.46e-02	2.11e-01	0.10500	0.011100	-1.05e-01	8.93e-01	2.05e-01
Estrogen-dependent gene expression	91	3.65e-01	5.32e-01	0.10500	-0.085300	-6.13e-02	1.59e-01	3.12e-01
PI-3K cascade:FGFR4	19	6.75e-01	7.79e-01	0.10500	-0.038300	-9.77e-02	7.72e-01	4.61e-01
Protein localization	147	1.76e-01	3.60e-01	0.10500	0.087100	5.83e-02	6.83e-02	2.22e-01
Olfactory Signaling Pathway	366	3.72e-04	3.27e-03	0.10500	-0.036000	-9.84e-02	2.36e-01	1.21e-03
Signaling by ALK	26	7.75e-01	8.49e-01	0.10500	-0.080700	-6.65e-02	4.76e-01	5.57e-01
Sulfur amino acid metabolism	27	5.44e-01	6.78e-01	0.10400	-0.034300	-9.85e-02	7.58e-01	3.76e-01
Association of TriC/CCT with target proteins during biosynthesis	38	2.29e-01	4.15e-01	0.10400	-0.008410	-1.04e-01	9.28e-01	2.68e-01
SUMOylation of ubiquitinylation proteins	37	5.31e-01	6.67e-01	0.10400	-0.044400	-9.41e-02	6.40e-01	3.22e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	6.66e-01	7.72e-01	0.10400	0.096100	3.99e-02	4.46e-01	7.51e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	6.66e-01	7.72e-01	0.10400	0.096100	3.99e-02	4.46e-01	7.51e-01
FGFR3 mutant receptor activation	11	7.33e-01	8.22e-01	0.10400	0.024200	1.01e-01	8.89e-01	5.62e-01
Signaling by activated point mutants of FGFR3	11	7.33e-01	8.22e-01	0.10400	0.024200	1.01e-01	8.89e-01	5.62e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	29	4.16e-01	5.72e-01	0.10400	-0.102000	-2.09e-02	3.44e-01	8.45e-01
Trafficking of AMPA receptors	29	4.16e-01	5.72e-01	0.10400	-0.102000	-2.09e-02	3.44e-01	8.45e-01
Transport of bile salts and organic acids, metal ions and amine compounds	84	1.05e-01	2.60e-01	0.10400	-0.100000	-2.61e-02	1.12e-01	6.79e-01
Budding and maturation of HIV virion	28	2.08e-01	3.90e-01	0.10300	0.018900	-1.01e-01	8.63e-01	3.53e-01
Signaling by NTRK1 (TRKA)	114	3.65e-01	5.32e-01	0.10300	-0.074700	-7.05e-02	1.68e-01	1.93e-01
Signaling by WNT	263	1.80e-03	1.22e-02	0.10300	-0.098400	-2.96e-02	5.98e-03	4.07e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	1.97e-01	3.82e-01	0.10300	-0.000563	-1.03e-01	9.95e-01	2.74e-01
Transcriptional regulation by RUNX1	183	2.64e-03	1.65e-02	0.10200	-0.101000	-1.55e-02	1.83e-02	7.17e-01
Retinoid metabolism and transport	42	6.41e-01	7.51e-01	0.10200	-0.083300	-5.93e-02	3.50e-01	5.06e-01
FCGR3A-mediated phagocytosis	57	1.97e-01	3.82e-01	0.10200	-0.099400	-2.15e-02	1.94e-01	7.79e-01
Leishmania phagocytosis	57	1.97e-01	3.82e-01	0.10200	-0.099400	-2.15e-02	1.94e-01	7.79e-01
Parasite infection	57	1.97e-01	3.82e-01	0.10200	-0.099400	-2.15e-02	1.94e-01	7.79e-01
Downstream signaling of activated FGFR4	26	7.91e-01	8.60e-01	0.10200	-0.066500	-7.70e-02	5.57e-01	4.97e-01
Metabolism of Angiotensinogen to Angiotensins	15	8.31e-01	8.84e-01	0.10200	-0.086700	-5.30e-02	5.61e-01	7.22e-01
Acetylcholine Neurotransmitter Release Cycle	16	5.38e-01	6.74e-01	0.10100	-0.101000	-5.29e-03	4.83e-01	9.71e-01
Disease	1567	1.40e-06	3.74e-05	0.10100	-0.078000	-6.48e-02	2.18e-07	1.65e-05
tRNA processing	98	2.89e-02	1.08e-01	0.10100	0.101000	8.94e-03	8.40e-02	8.78e-01
Signaling by NOTCH2	32	6.76e-01	7.79e-01	0.10100	0.086300	5.26e-02	3.98e-01	6.06e-01
Activated NTRK2 signals through FRS2 and FRS3	11	9.09e-01	9.38e-01	0.10100	-0.074900	-6.74e-02	6.67e-01	6.99e-01
The citric acid (TCA) cycle and respiratory electron transport	143	2.72e-02	1.04e-01	0.10100	0.097300	2.55e-02	4.44e-02	5.99e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	22	3.75e-01	5.39e-01	0.10000	0.100000	-5.22e-03	4.17e-01	9.66e-01
Neurodegenerative Diseases	22	3.75e-01	5.39e-01	0.10000	0.100000	-5.22e-03	4.17e-01	9.66e-01
Interleukin-6 signaling	11	9.11e-01	9.38e-01	0.10000	-0.073900	-6.75e-02	6.71e-01	6.98e-01
FRS-mediated FGFR4 signaling	21	8.14e-01	8.71e-01	0.10000	-0.059300	-8.05e-02	6.38e-01	5.23e-01
Interleukin-15 signaling	13	8.60e-01	9.05e-01	0.10000	-0.084700	-5.31e-02	5.97e-01	7.40e-01
Acyl chain remodelling of PG	18	4.12e-01	5.71e-01	0.09980	-0.012900	9.90e-02	9.24e-01	4.67e-01
FGFR1 mutant receptor activation	30	2.53e-01	4.38e-01	0.09950	-0.099100	8.11e-03	3.47e-01	9.39e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	31	2.72e-01	4.54e-01	0.09940	0.002120	-9.94e-02	9.84e-01	3.38e-01
Degradation of cysteine and homocysteine	14	6.36e-01	7.47e-01	0.09920	-0.012500	-9.84e-02	9.35e-01	5.24e-01
Translesion synthesis by REV1	16	4.86e-01	6.34e-01	0.09920	0.007440	-9.89e-02	9.59e-01	4.93e-01
CD28 dependent Vav1 pathway	11	5.99e-01	7.19e-01	0.09830	0.097700	-1.09e-02	5.75e-01	9.50e-01
PIWI-interacting RNA (piRNA) biogenesis	29	1.58e-01	3.38e-01	0.09800	-0.041800	8.86e-02	6.97e-01	4.09e-01
GABA synthesis, release, reuptake and degradation	19	4.96e-01	6.41e-01	0.09750	-0.097500	-3.31e-03	4.62e-01	9.80e-01
RHO GTPases activate CIT	19	6.81e-01	7.83e-01	0.09720	-0.092300	-3.07e-02	4.86e-01	8.17e-01
Deposition of new CENPA-containing nucleosomes at the centromere	26	2.71e-01	4.54e-01	0.09720	0.018300	-9.55e-02	8.72e-01	3.99e-01
Nucleosome assembly	26	2.71e-01	4.54e-01	0.09720	0.018300	-9.55e-02	8.72e-01	3.99e-01
FGFR2c ligand binding and activation	12	7.92e-01	8.60e-01	0.09690	0.032000	9.15e-02	8.48e-01	5.83e-01
Gap junction assembly	18	5.42e-01	6.76e-01	0.09670	0.096400	6.96e-03	4.79e-01	9.59e-01
SLC transporter disorders	92	2.55e-01	4.40e-01	0.09660	-0.087600	-4.09e-02	1.46e-01	4.98e-01
Acyl chain remodelling of PC	26	1.68e-01	3.52e-01	0.09650	-0.066700	6.97e-02	5.56e-01	5.38e-01
Plasma lipoprotein clearance	37	7.52e-01	8.34e-01	0.09600	-0.069500	-6.63e-02	4.64e-01	4.85e-01
AKT phosphorylates targets in the cytosol	14	4.00e-01	5.61e-01	0.09600	-0.080300	5.27e-02	6.03e-01	7.33e-01
Resolution of D-Loop Structures	31	5.97e-01	7.18e-01	0.09530	-0.035600	-8.84e-02	7.31e-01	3.94e-01
RHOBTB2 GTPase cycle	22	7.86e-01	8.55e-01	0.09490	0.081400	4.89e-02	5.09e-01	6.91e-01
The canonical retinoid cycle in rods (twilight vision)	23	3.30e-01	5.06e-01	0.09480	-0.093000	1.86e-02	4.40e-01	8.77e-01
RAF-independent MAPK1/3 activation	22	8.48e-01	8.96e-01	0.09480	0.068500	6.55e-02	5.78e-01	5.95e-01
Global Genome Nucleotide Excision Repair (GG-NER)	81	9.67e-03	4.63e-02	0.09460	0.036200	-8.74e-02	5.73e-01	1.74e-01
Phase II - Conjugation of compounds	106	2.00e-01	3.86e-01	0.09400	-0.037300	-8.63e-02	5.07e-01	1.24e-01
Activation of ATR in response to replication stress	37	1.94e-01	3.79e-01	0.09400	0.013200	-9.31e-02	8.90e-01	3.27e-01
RHO GTPases Activate WASPs and WAVEs	34	7.77e-01	8.49e-01	0.09400	0.064200	6.86e-02	5.17e-01	4.88e-01
RNA Polymerase II Transcription Termination	62	8.46e-02	2.28e-01	0.09390	0.093700	-6.08e-03	2.02e-01	9.34e-01
Activation of SMO	17	8.23e-01	8.77e-01	0.09380	-0.081700	-4.61e-02	5.60e-01	7.42e-01
RNA Polymerase III Transcription Termination	23	6.24e-01	7.41e-01	0.09380	-0.026500	-9.00e-02	8.26e-01	4.55e-01
Interleukin-1 family signaling	145	1.24e-01	2.88e-01	0.09350	0.038400	8.53e-02	4.25e-01	7.62e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	49	6.29e-01	7.44e-01	0.09340	-0.051800	-7.77e-02	5.30e-01	3.47e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	5.92e-01	7.16e-01	0.09310	-0.004500	-9.29e-02	9.75e-01	5.20e-01
Metabolism	1963	2.37e-06	6.00e-05	0.09240	-0.066100	-6.46e-02	1.07e-06	1.90e-06
Mitotic G1 phase and G1/S transition	144	2.29e-01	4.15e-01	0.09100	0.078400	4.63e-02	1.04e-01	3.38e-01
Phospholipase C-mediated cascade; FGFR2	17	6.42e-01	7.51e-01	0.09080	0.013100	8.98e-02	9.25e-01	5.21e-01
SHC-mediated cascade:FGFR3	17	6.34e-01	7.46e-01	0.09080	-0.090000	-1.20e-02	5.21e-01	9.32e-01
Fatty acid metabolism	167	3.07e-01	4.84e-01	0.09060	-0.068400	-5.94e-02	1.27e-01	1.85e-01
Triglyceride metabolism	36	7.44e-01	8.29e-01	0.09050	-0.073500	-5.28e-02	4.45e-01	5.83e-01
Citric acid cycle (TCA cycle)	21	3.20e-01	4.98e-01	0.09040	0.038900	-8.16e-02	7.58e-01	5.17e-01
PTEN Regulation	150	3.37e-01	5.11e-01	0.09020	-0.069600	-5.74e-02	1.41e-01	2.25e-01
Neutrophil degranulation	458	1.54e-04	1.55e-03	0.09010	-0.086800	-2.44e-02	1.43e-03	3.70e-01
Telomere C-strand synthesis initiation	11	5.26e-01	6.62e-01	0.09000	0.072800	-5.28e-02	6.76e-01	7.62e-01
PI-3K cascade:FGFR1	21	8.10e-01	8.69e-01	0.08990	0.077400	4.56e-02	5.39e-01	7.17e-01
Recognition of DNA damage by PCNA-containing replication complex	29	1.81e-01	3.66e-01	0.08940	0.063000	-6.34e-02	5.57e-01	5.55e-01
Transport of the SLBP independent Mature mRNA	33	2.69e-01	4.54e-01	0.08910	0.012500	-8.82e-02	9.01e-01	3.81e-01
Signaling by CSF3 (G-CSF)	28	7.72e-01	8.47e-01	0.08840	0.075300	4.63e-02	4.91e-01	6.72e-01
Advanced glycosylation endproduct receptor signaling	13	5.89e-01	7.15e-01	0.08810	0.086700	-1.56e-02	5.88e-01	9.22e-01
Fertilization	26	4.97e-01	6.42e-01	0.08790	0.008400	8.75e-02	9.41e-01	4.40e-01
Mitotic Metaphase and Anaphase	222	3.17e-02	1.16e-01	0.08780	0.082700	2.95e-02	3.37e-02	4.49e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	3.55e-01	5.25e-01	0.08740	0.087200	5.83e-03	3.59e-01	9.51e-01
HATs acetylate histones	71	9.61e-02	2.48e-01	0.08720	-0.087200	3.24e-03	2.04e-01	9.62e-01
RNA Polymerase III Transcription Initiation	36	2.23e-01	4.09e-01	0.08690	0.084800	-1.92e-02	3.79e-01	8.42e-01
Nuclear Envelope (NE) Reassembly	73	2.43e-02	9.61e-02	0.08690	0.039700	-7.73e-02	5.57e-01	2.54e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	4.82e-01	6.31e-01	0.08650	0.002740	8.65e-02	9.81e-01	4.54e-01
Fanconi Anemia Pathway	36	6.85e-01	7.85e-01	0.08650	0.076500	4.03e-02	4.27e-01	6.75e-01
DAP12 interactions	40	1.35e-01	3.06e-01	0.08640	-0.077400	3.85e-02	3.97e-01	6.74e-01
NEP/NS2 Interacts with the Cellular Export Machinery	30	4.46e-01	6.00e-01	0.08620	-0.006380	-8.60e-02	9.52e-01	4.15e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	7.07e-01	8.03e-01	0.08620	-0.083200	-2.25e-02	5.30e-01	8.65e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	5.78e-01	7.05e-01	0.08610	-0.028900	8.11e-02	8.62e-01	6.27e-01
Glutathione conjugation	36	6.82e-01	7.84e-01	0.08550	0.076100	3.89e-02	4.29e-01	6.86e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	30	5.15e-01	6.58e-01	0.08520	-0.014000	-8.41e-02	8.94e-01	4.25e-01
DNA Double-Strand Break Repair	129	5.08e-02	1.59e-01	0.08520	-0.011900	-8.43e-02	8.15e-01	9.80e-02
Ub-specific processing proteases	153	3.94e-01	5.55e-01	0.08480	0.062900	5.69e-02	1.79e-01	2.25e-01
Constitutive Signaling by Overexpressed ERBB2	10	8.45e-01	8.96e-01	0.08450	-0.081200	-2.35e-02	6.57e-01	8.98e-01
RHOBTB1 GTPase cycle	22	3.91e-01	5.52e-01	0.08440	0.025700	-8.04e-02	8.35e-01	5.14e-01
MicroRNA (miRNA) biogenesis	26	2.72e-01	4.54e-01	0.08420	-0.045300	7.09e-02	6.89e-01	5.31e-01
Mitotic Anaphase	221	3.76e-02	1.30e-01	0.08390	0.079500	2.68e-02	4.15e-02	4.92e-01
Viral Messenger RNA Synthesis	42	3.30e-01	5.06e-01	0.08380	0.083600	4.27e-03	3.48e-01	9.62e-01
PECAM1 interactions	12	5.42e-01	6.76e-01	0.08340	-0.053700	6.39e-02	7.47e-01	7.02e-01
Regulation of actin dynamics for phagocytic cup formation	59	3.62e-01	5.30e-01	0.08310	-0.080400	-2.11e-02	2.85e-01	7.79e-01
Dual Incision in GG-NER	39	4.54e-01	6.08e-01	0.08280	-0.014800	-8.15e-02	8.73e-01	3.78e-01
Plasma lipoprotein assembly, remodeling, and clearance	73	4.17e-01	5.73e-01	0.08270	-0.076100	-3.22e-02	2.61e-01	6.34e-01
Regulation of TP53 Expression and Degradation	37	5.61e-01	6.92e-01	0.08230	-0.078900	-2.36e-02	4.06e-01	8.04e-01
Intraflagellar transport	36	6.58e-01	7.65e-01	0.08190	-0.032300	-7.53e-02	7.37e-01	4.34e-01
Retrograde transport at the Trans-Golgi-Network	47	7.16e-01	8.10e-01	0.08170	-0.067600	-4.58e-02	4.22e-01	5.87e-01
The role of Nef in HIV-1 replication and disease pathogenesis	27	5.12e-01	6.54e-01	0.08130	-0.081200	-4.34e-03	4.65e-01	9.69e-01
Transport of Ribonucleoproteins into the Host Nucleus	30	4.08e-01	5.68e-01	0.08090	0.005820	-8.07e-02	9.56e-01	4.44e-01
Regulation of TP53 Activity through Phosphorylation	88	2.72e-02	1.04e-01	0.08090	0.075600	-2.88e-02	2.20e-01	6.41e-01
Signaling by FGFR2 IIIa TM	19	6.23e-01	7.41e-01	0.08080	0.080700	3.57e-03	5.42e-01	9.79e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	4.40e-01	5.95e-01	0.08080	0.080500	-6.85e-03	4.69e-01	9.51e-01
Downstream signaling of activated FGFR3	24	7.79e-01	8.50e-01	0.08060	-0.073100	-3.40e-02	5.35e-01	7.73e-01
Death Receptor Signalling	134	2.70e-01	4.54e-01	0.08030	-0.072100	-3.53e-02	1.49e-01	4.81e-01
Acyl chain remodelling of PE	24	3.30e-01	5.06e-01	0.07950	-0.050900	6.11e-02	6.66e-01	6.04e-01
Impaired BRCA2 binding to RAD51	33	2.37e-01	4.24e-01	0.07940	0.039500	-6.90e-02	6.95e-01	4.93e-01
Downregulation of ERBB2:ERBB3 signaling	13	5.80e-01	7.06e-01	0.07920	-0.034900	7.11e-02	8.28e-01	6.57e-01
Response to metal ions	14	6.79e-01	7.81e-01	0.07920	0.079100	-3.78e-03	6.08e-01	9.80e-01
Late endosomal microautophagy	32	7.11e-01	8.05e-01	0.07910	-0.031700	-7.25e-02	7.56e-01	4.78e-01
SHC-mediated cascade:FGFR1	21	8.52e-01	8.99e-01	0.07900	0.040500	6.78e-02	7.48e-01	5.91e-01
Ovarian tumor domain proteases	36	7.28e-01	8.19e-01	0.07880	-0.069900	-3.65e-02	4.68e-01	7.05e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	29	7.62e-01	8.40e-01	0.07860	-0.070600	-3.46e-02	5.11e-01	7.47e-01
VLDLR internalisation and degradation	16	8.91e-01	9.22e-01	0.07850	0.066700	4.14e-02	6.44e-01	7.74e-01
NoRC negatively regulates rRNA expression	43	1.63e-01	3.45e-01	0.07820	0.038300	-6.82e-02	6.64e-01	4.39e-01
Activated point mutants of FGFR2	16	7.21e-01	8.12e-01	0.07810	0.009100	7.76e-02	9.50e-01	5.91e-01
Negative regulation of FGFR3 signaling	28	8.64e-01	9.07e-01	0.07800	0.058500	5.17e-02	5.92e-01	6.36e-01
Antiviral mechanism by IFN-stimulated genes	78	3.84e-01	5.47e-01	0.07800	0.073400	2.65e-02	2.62e-01	6.86e-01
Transport of Mature Transcript to Cytoplasm	76	2.09e-01	3.90e-01	0.07700	0.076700	7.35e-03	2.48e-01	9.12e-01
Transport of vitamins, nucleosides, and related molecules	38	7.88e-01	8.58e-01	0.07660	-0.063400	-4.30e-02	4.99e-01	6.46e-01
Selective autophagy	59	7.83e-02	2.18e-01	0.07660	0.056300	-5.19e-02	4.54e-01	4.90e-01
E3 ubiquitin ligases ubiquitinate target proteins	43	7.39e-01	8.27e-01	0.07610	0.039200	6.52e-02	6.57e-01	4.59e-01
Plasma lipoprotein remodeling	32	4.98e-01	6.43e-01	0.07560	-0.075500	-3.34e-03	4.60e-01	9.74e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	4.89e-01	6.38e-01	0.07550	0.075400	-4.39e-03	4.90e-01	9.68e-01
SHC-mediated cascade:FGFR2	22	6.23e-01	7.41e-01	0.07510	-0.075100	-3.38e-03	5.42e-01	9.78e-01
Antigen processing: Ubiquitination & Proteasome degradation	293	1.83e-01	3.67e-01	0.07510	-0.061700	-4.28e-02	6.90e-02	2.07e-01
Presynaptic nicotinic acetylcholine receptors	12	9.39e-01	9.58e-01	0.07510	0.046300	5.91e-02	7.81e-01	7.23e-01
Gluconeogenesis	32	7.96e-01	8.63e-01	0.07500	-0.037700	-6.49e-02	7.12e-01	5.25e-01
Prolactin receptor signaling	15	9.21e-01	9.43e-01	0.07460	-0.044000	-6.02e-02	7.68e-01	6.86e-01
InlB-mediated entry of Listeria monocytogenes into host cell	14	6.31e-01	7.44e-01	0.07450	0.021800	-7.12e-02	8.87e-01	6.45e-01
Gap junction trafficking	27	8.75e-01	9.12e-01	0.07430	-0.047200	-5.73e-02	6.71e-01	6.06e-01
RIP-mediated NFkB activation via ZBP1	16	5.82e-01	7.07e-01	0.07410	0.024800	-6.98e-02	8.63e-01	6.29e-01
Metabolism of steroid hormones	33	6.98e-01	7.97e-01	0.07390	0.025500	6.94e-02	8.00e-01	4.90e-01
Processing and activation of SUMO	10	7.12e-01	8.06e-01	0.07390	0.025600	-6.94e-02	8.89e-01	7.04e-01
Early Phase of HIV Life Cycle	14	8.03e-01	8.64e-01	0.07380	0.072400	1.40e-02	6.39e-01	9.28e-01
Signaling by FLT3 ITD and TKD mutants	16	8.69e-01	9.10e-01	0.07370	-0.030800	-6.69e-02	8.31e-01	6.43e-01
SARS-CoV Infections	387	1.00e-01	2.53e-01	0.07330	-0.039800	-6.16e-02	1.78e-01	3.73e-02
Signaling by FGFR2	72	2.94e-01	4.78e-01	0.07300	0.072300	1.03e-02	2.89e-01	8.80e-01
Homology Directed Repair	99	1.78e-01	3.61e-01	0.07290	-0.009190	-7.24e-02	8.74e-01	2.13e-01
NOTCH3 Intracellular Domain Regulates Transcription	24	6.14e-01	7.32e-01	0.07280	0.002890	7.27e-02	9.80e-01	5.38e-01
Transcriptional Regulation by TP53	346	8.17e-02	2.23e-01	0.07230	-0.033800	-6.40e-02	2.79e-01	4.07e-02
Negative epigenetic regulation of rRNA expression	45	1.98e-01	3.83e-01	0.07210	0.035900	-6.26e-02	6.77e-01	4.68e-01
Nucleotide Excision Repair	107	1.73e-02	7.29e-02	0.07210	0.055500	-4.61e-02	3.21e-01	4.10e-01
FRS-mediated FGFR3 signaling	19	8.32e-01	8.84e-01	0.07210	-0.067000	-2.66e-02	6.13e-01	8.41e-01
Membrane binding and targetting of GAG proteins	14	8.48e-01	8.96e-01	0.07200	-0.021100	-6.88e-02	8.91e-01	6.56e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	8.48e-01	8.96e-01	0.07200	-0.021100	-6.88e-02	8.91e-01	6.56e-01
NS1 Mediated Effects on Host Pathways	39	2.39e-01	4.26e-01	0.07180	0.039900	-5.97e-02	6.66e-01	5.19e-01
GPCR ligand binding	443	6.91e-04	5.31e-03	0.07170	-0.071100	-9.51e-03	1.02e-02	7.31e-01
Termination of translesion DNA synthesis	31	4.86e-01	6.35e-01	0.07130	0.005180	-7.11e-02	9.60e-01	4.93e-01
Signaling by FGFR in disease	61	3.62e-01	5.30e-01	0.07080	-0.070300	-8.41e-03	3.42e-01	9.10e-01
Developmental Biology	1027	5.72e-04	4.58e-03	0.07040	-0.063300	-3.09e-02	5.76e-04	9.25e-02
TP53 Regulates Metabolic Genes	83	7.04e-01	8.01e-01	0.07040	-0.046900	-5.25e-02	4.60e-01	4.08e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	29	3.62e-01	5.30e-01	0.07010	-0.058200	3.92e-02	5.88e-01	7.15e-01
Disorders of transmembrane transporters	167	5.03e-01	6.47e-01	0.07010	0.051400	4.76e-02	2.51e-01	2.88e-01
Transcriptional regulation of white adipocyte differentiation	81	6.01e-01	7.21e-01	0.06990	-0.034700	-6.07e-02	5.89e-01	3.45e-01
Cholesterol biosynthesis	24	8.09e-01	8.69e-01	0.06990	0.064700	2.65e-02	5.83e-01	8.22e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	15	6.83e-01	7.84e-01	0.06930	-0.068100	1.28e-02	6.48e-01	9.32e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	23	4.75e-01	6.23e-01	0.06920	0.061600	-3.16e-02	6.09e-01	7.93e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	23	4.75e-01	6.23e-01	0.06920	0.061600	-3.16e-02	6.09e-01	7.93e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	23	4.75e-01	6.23e-01	0.06920	0.061600	-3.16e-02	6.09e-01	7.93e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	23	4.75e-01	6.23e-01	0.06920	0.061600	-3.16e-02	6.09e-01	7.93e-01
Impaired BRCA2 binding to PALB2	23	4.75e-01	6.23e-01	0.06920	0.061600	-3.16e-02	6.09e-01	7.93e-01
DNA Repair	276	3.09e-03	1.88e-02	0.06910	0.003410	-6.90e-02	9.22e-01	4.82e-02
Inflammasomes	21	5.06e-01	6.49e-01	0.06900	0.032400	-6.09e-02	7.97e-01	6.29e-01
Downstream signaling of activated FGFR2	29	7.60e-01	8.40e-01	0.06890	-0.064700	-2.37e-02	5.46e-01	8.25e-01
Transcriptional activation of mitochondrial biogenesis	51	6.23e-01	7.41e-01	0.06870	-0.064400	-2.40e-02	4.26e-01	7.67e-01
Translesion synthesis by POLI	17	5.59e-01	6.90e-01	0.06870	0.054800	-4.15e-02	6.96e-01	7.67e-01
FRS-mediated FGFR1 signaling	23	9.14e-01	9.39e-01	0.06860	0.048200	4.88e-02	6.89e-01	6.85e-01
Chromosome Maintenance	86	1.14e-01	2.74e-01	0.06700	0.016300	-6.50e-02	7.94e-01	2.97e-01
Regulation of FZD by ubiquitination	21	9.13e-01	9.39e-01	0.06680	-0.039900	-5.36e-02	7.52e-01	6.71e-01
Glutamate Neurotransmitter Release Cycle	23	5.70e-01	7.00e-01	0.06680	-0.014400	6.52e-02	9.05e-01	5.88e-01
MyD88-independent TLR4 cascade	103	5.66e-01	6.97e-01	0.06660	-0.057400	-3.37e-02	3.14e-01	5.54e-01
TRIF(TICAM1)-mediated TLR4 signaling	103	5.66e-01	6.97e-01	0.06660	-0.057400	-3.37e-02	3.14e-01	5.54e-01
NPAS4 regulates expression of target genes	21	9.13e-01	9.39e-01	0.06660	-0.053500	-3.96e-02	6.71e-01	7.53e-01
Interferon gamma signaling	89	5.59e-01	6.90e-01	0.06650	-0.059400	-2.99e-02	3.32e-01	6.26e-01
Intrinsic Pathway for Apoptosis	52	8.22e-01	8.77e-01	0.06650	-0.044400	-4.95e-02	5.80e-01	5.37e-01
Negative regulation of FGFR2 signaling	33	8.86e-01	9.20e-01	0.06630	0.046000	4.78e-02	6.48e-01	6.35e-01
Class I MHC mediated antigen processing & presentation	361	9.71e-02	2.50e-01	0.06580	-0.059000	-2.90e-02	5.38e-02	3.43e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	4.94e-01	6.40e-01	0.06550	0.004750	-6.53e-02	9.61e-01	4.98e-01
ZBP1(DAI) mediated induction of type I IFNs	20	7.65e-01	8.42e-01	0.06520	0.064500	9.72e-03	6.17e-01	9.40e-01
Sodium/Calcium exchangers	11	9.62e-01	9.72e-01	0.06520	-0.046500	-4.57e-02	7.90e-01	7.93e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	3.25e-01	5.02e-01	0.06440	0.055600	-3.25e-02	5.48e-01	7.25e-01
Diseases of DNA Double-Strand Break Repair	39	3.25e-01	5.02e-01	0.06440	0.055600	-3.25e-02	5.48e-01	7.25e-01
Negative regulators of DDX58/IFIH1 signaling	34	7.49e-01	8.32e-01	0.06420	-0.021200	-6.06e-02	8.30e-01	5.41e-01
Mitochondrial tRNA aminoacylation	18	9.39e-01	9.58e-01	0.06410	-0.042800	-4.77e-02	7.53e-01	7.26e-01
Assembly Of The HIV Virion	16	9.46e-01	9.62e-01	0.06390	-0.046800	-4.35e-02	7.46e-01	7.63e-01
MAPK3 (ERK1) activation	10	8.53e-01	8.99e-01	0.06390	-0.063900	-2.08e-03	7.27e-01	9.91e-01
RNA Polymerase III Abortive And Retractive Initiation	41	4.92e-01	6.39e-01	0.06350	0.001830	-6.35e-02	9.84e-01	4.82e-01
RNA Polymerase III Transcription	41	4.92e-01	6.39e-01	0.06350	0.001830	-6.35e-02	9.84e-01	4.82e-01
Negative regulation of MAPK pathway	41	8.46e-01	8.96e-01	0.06340	-0.036700	-5.17e-02	6.84e-01	5.67e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	93	3.85e-01	5.48e-01	0.06330	-0.015300	-6.14e-02	7.99e-01	3.06e-01
RNA Polymerase I Transcription Initiation	42	7.61e-01	8.40e-01	0.06330	-0.057500	-2.64e-02	5.19e-01	7.67e-01
WNT5A-dependent internalization of FZD4	15	7.46e-01	8.30e-01	0.06190	-0.009370	6.12e-02	9.50e-01	6.81e-01
Metabolism of porphyrins	27	9.12e-01	9.39e-01	0.06190	-0.039700	-4.75e-02	7.21e-01	6.69e-01
HDR through Homologous Recombination (HRR)	64	2.46e-01	4.32e-01	0.06180	0.016000	-5.97e-02	8.25e-01	4.08e-01
Postmitotic nuclear pore complex (NPC) reformation	26	4.92e-01	6.39e-01	0.06180	0.051100	-3.48e-02	6.52e-01	7.59e-01
Export of Viral Ribonucleoproteins from Nucleus	31	4.66e-01	6.20e-01	0.06160	0.024500	-5.65e-02	8.13e-01	5.86e-01
Metabolism of proteins	1767	2.34e-03	1.52e-02	0.06140	-0.036600	-4.93e-02	1.01e-02	5.27e-04
FOXO-mediated transcription	65	4.02e-01	5.61e-01	0.06120	0.003330	6.11e-02	9.63e-01	3.94e-01
Peroxisomal lipid metabolism	28	7.78e-01	8.49e-01	0.06120	0.016500	5.89e-02	8.80e-01	5.90e-01
RUNX3 regulates NOTCH signaling	13	8.53e-01	8.99e-01	0.06110	0.007950	6.06e-02	9.60e-01	7.05e-01
Nicotinamide salvaging	17	8.90e-01	9.22e-01	0.06110	0.056700	2.28e-02	6.86e-01	8.71e-01
XBP1(S) activates chaperone genes	47	5.02e-01	6.47e-01	0.06090	-0.060900	-1.40e-03	4.70e-01	9.87e-01
Glycogen storage diseases	14	9.58e-01	9.70e-01	0.06040	0.040900	4.45e-02	7.91e-01	7.73e-01
FRS-mediated FGFR2 signaling	24	8.08e-01	8.68e-01	0.06020	-0.058100	-1.57e-02	6.22e-01	8.94e-01
FLT3 Signaling	38	5.76e-01	7.04e-01	0.05990	-0.059900	-5.04e-04	5.22e-01	9.96e-01
Interleukin-7 signaling	21	9.36e-01	9.57e-01	0.05960	-0.038300	-4.57e-02	7.61e-01	7.17e-01
PI-3K cascade:FGFR3	17	9.50e-01	9.63e-01	0.05940	-0.044400	-3.94e-02	7.51e-01	7.79e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	8.56e-01	9.01e-01	0.05920	0.058600	8.52e-03	7.04e-01	9.56e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	62	2.20e-01	4.05e-01	0.05900	0.050300	-3.09e-02	4.93e-01	6.74e-01
MAPK family signaling cascades	311	8.14e-02	2.23e-01	0.05850	-0.056300	-1.60e-02	8.76e-02	6.27e-01
Gene expression (Transcription)	1420	1.86e-02	7.69e-02	0.05820	-0.037800	-4.43e-02	1.65e-02	4.95e-03
Presynaptic phase of homologous DNA pairing and strand exchange	38	4.02e-01	5.61e-01	0.05810	0.032200	-4.83e-02	7.31e-01	6.06e-01
Metabolism of fat-soluble vitamins	46	7.52e-01	8.34e-01	0.05790	-0.053800	-2.15e-02	5.28e-01	8.01e-01
Pregnenolone biosynthesis	10	9.70e-01	9.77e-01	0.05780	0.036200	4.51e-02	8.43e-01	8.05e-01
SARS-CoV-2-host interactions	183	1.62e-01	3.44e-01	0.05780	0.057000	9.99e-03	1.84e-01	8.16e-01
Cleavage of the damaged pyrimidine	16	7.42e-01	8.28e-01	0.05750	0.014000	-5.58e-02	9.23e-01	6.99e-01
Depyrimidination	16	7.42e-01	8.28e-01	0.05750	0.014000	-5.58e-02	9.23e-01	6.99e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	16	7.42e-01	8.28e-01	0.05750	0.014000	-5.58e-02	9.23e-01	6.99e-01
HDR through Single Strand Annealing (SSA)	36	5.50e-01	6.82e-01	0.05740	0.008420	-5.67e-02	9.30e-01	5.56e-01
Androgen biosynthesis	11	8.01e-01	8.64e-01	0.05720	-0.019200	5.39e-02	9.12e-01	7.57e-01
Late Phase of HIV Life Cycle	126	8.29e-02	2.25e-01	0.05690	0.053700	-1.88e-02	2.98e-01	7.16e-01
Mitotic Spindle Checkpoint	106	4.10e-01	5.70e-01	0.05680	-0.013300	-5.53e-02	8.13e-01	3.25e-01
Processing of DNA double-strand break ends	61	2.41e-01	4.28e-01	0.05640	0.042200	-3.73e-02	5.68e-01	6.14e-01
Post-chaperonin tubulin folding pathway	23	5.86e-01	7.12e-01	0.05630	0.035800	-4.35e-02	7.66e-01	7.18e-01
ISG15 antiviral mechanism	71	3.59e-01	5.29e-01	0.05630	0.056200	-3.93e-03	4.13e-01	9.54e-01
C-type lectin receptors (CLRs)	137	4.20e-02	1.40e-01	0.05630	-0.037000	4.24e-02	4.54e-01	3.92e-01
Homologous DNA Pairing and Strand Exchange	41	3.86e-01	5.48e-01	0.05620	0.039300	-4.01e-02	6.63e-01	6.57e-01
Negative regulation of FGFR4 signaling	30	7.45e-01	8.30e-01	0.05620	0.055500	8.66e-03	5.99e-01	9.35e-01
HIV Life Cycle	139	6.61e-02	1.94e-01	0.05610	0.052600	-1.95e-02	2.84e-01	6.91e-01
SUMOylation of SUMOylation proteins	33	4.69e-01	6.20e-01	0.05610	0.035500	-4.35e-02	7.24e-01	6.66e-01
Interleukin-4 and Interleukin-13 signaling	104	4.01e-01	5.61e-01	0.05590	0.011200	5.48e-02	8.43e-01	3.34e-01
Protein ubiquitination	61	7.92e-01	8.60e-01	0.05570	0.047900	2.85e-02	5.18e-01	7.00e-01
Cell Cycle Checkpoints	248	6.98e-02	2.01e-01	0.05550	0.055300	4.98e-03	1.34e-01	8.93e-01
G2/M Transition	175	6.27e-01	7.43e-01	0.05510	0.042200	3.55e-02	3.36e-01	4.18e-01
Mitotic G2-G2/M phases	177	6.06e-01	7.25e-01	0.05440	0.043400	3.28e-02	3.18e-01	4.51e-01
tRNA modification in the nucleus and cytosol	38	5.13e-01	6.56e-01	0.05420	0.016200	-5.17e-02	8.62e-01	5.81e-01
Regulation of HSF1-mediated heat shock response	78	2.45e-01	4.31e-01	0.05390	0.050600	-1.86e-02	4.40e-01	7.76e-01
IRE1alpha activates chaperones	49	5.59e-01	6.90e-01	0.05380	-0.053800	-1.43e-05	5.15e-01	1.00e+00
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	35	5.16e-01	6.58e-01	0.05350	0.048600	-2.25e-02	6.19e-01	8.18e-01
Immune System	1870	1.45e-05	2.73e-04	0.05350	-0.051100	-1.60e-02	2.28e-04	2.49e-01
FLT3 signaling in disease	28	9.07e-01	9.36e-01	0.05350	-0.045900	-2.75e-02	6.74e-01	8.01e-01
Adaptive Immune System	709	1.20e-02	5.49e-02	0.05340	-0.051000	-1.59e-02	2.04e-02	4.70e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	76	2.06e-01	3.88e-01	0.05320	0.040000	-3.51e-02	5.47e-01	5.96e-01
Cell Cycle	601	1.78e-02	7.46e-02	0.05300	-0.014000	-5.11e-02	5.57e-01	3.19e-02
Glycolysis	68	7.89e-01	8.58e-01	0.05290	-0.026800	-4.56e-02	7.02e-01	5.15e-01
Nicotinate metabolism	29	7.70e-01	8.46e-01	0.05280	-0.007070	-5.23e-02	9.47e-01	6.26e-01
Class A/1 (Rhodopsin-like receptors)	311	1.08e-02	5.00e-02	0.05270	-0.009780	5.18e-02	7.67e-01	1.16e-01
Signaling by Hedgehog	133	3.73e-01	5.38e-01	0.05260	0.011700	5.13e-02	8.16e-01	3.06e-01
RHOBTB GTPase Cycle	34	5.03e-01	6.47e-01	0.05260	0.040600	-3.34e-02	6.82e-01	7.36e-01
Neurotransmitter release cycle	47	3.91e-01	5.52e-01	0.05240	-0.041100	3.25e-02	6.26e-01	7.00e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	6.14e-01	7.32e-01	0.05240	0.015300	-5.01e-02	8.85e-01	6.34e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	6.14e-01	7.32e-01	0.05240	0.015300	-5.01e-02	8.85e-01	6.34e-01
Transcriptional regulation by RUNX2	116	5.31e-01	6.67e-01	0.05240	0.018000	4.92e-02	7.38e-01	3.60e-01
Signaling by Leptin	11	9.66e-01	9.74e-01	0.05220	-0.044200	-2.78e-02	8.00e-01	8.73e-01
Nervous system development	527	7.60e-02	2.13e-01	0.05220	-0.048400	-1.96e-02	5.68e-02	4.40e-01
Neddylation	228	5.94e-01	7.17e-01	0.05210	0.038500	3.52e-02	3.17e-01	3.59e-01
Innate Immune System	999	2.01e-04	1.88e-03	0.05180	-0.051400	-6.44e-03	5.78e-03	7.30e-01
Beta-catenin independent WNT signaling	144	5.96e-02	1.80e-01	0.05170	-0.034700	3.83e-02	4.72e-01	4.27e-01
STAT5 activation downstream of FLT3 ITD mutants	10	9.22e-01	9.44e-01	0.05150	0.050800	8.43e-03	7.81e-01	9.63e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	75	3.72e-01	5.37e-01	0.05070	0.008180	-5.00e-02	9.03e-01	4.54e-01
TAK1-dependent IKK and NF-kappa-B activation	41	7.59e-01	8.40e-01	0.05060	0.011700	4.92e-02	8.97e-01	5.86e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14	8.11e-01	8.70e-01	0.04980	0.015400	-4.74e-02	9.21e-01	7.59e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	15	7.81e-01	8.51e-01	0.04970	-0.044800	2.17e-02	7.64e-01	8.84e-01
Generic Transcription Pathway	1163	1.05e-01	2.59e-01	0.04920	-0.034000	-3.56e-02	4.97e-02	3.98e-02
Interferon Signaling	191	3.19e-01	4.97e-01	0.04890	0.047300	1.22e-02	2.59e-01	7.71e-01
Post-translational modification: synthesis of GPI-anchored proteins	89	2.64e-01	4.48e-01	0.04890	-0.045700	1.74e-02	4.56e-01	7.76e-01
Cell Cycle, Mitotic	476	2.59e-02	1.00e-01	0.04860	-0.005920	-4.82e-02	8.25e-01	7.12e-02
Axon guidance	503	8.47e-02	2.28e-01	0.04860	-0.046000	-1.55e-02	7.68e-02	5.50e-01
RNA Polymerase I Transcription	47	8.01e-01	8.64e-01	0.04840	-0.045500	-1.64e-02	5.89e-01	8.45e-01
TRAF6 mediated NF-kB activation	24	9.15e-01	9.39e-01	0.04790	-0.020100	-4.35e-02	8.64e-01	7.12e-01
Aggrephagy	23	6.98e-01	7.97e-01	0.04740	0.024000	-4.09e-02	8.42e-01	7.34e-01
Cytoprotection by HMOX1	58	5.77e-01	7.05e-01	0.04720	-0.047200	1.12e-03	5.34e-01	9.88e-01
Formation of Incision Complex in GG-NER	40	6.88e-01	7.88e-01	0.04690	0.000996	-4.69e-02	9.91e-01	6.07e-01
Transcriptional regulation by small RNAs	46	7.47e-01	8.31e-01	0.04680	0.046000	8.86e-03	5.89e-01	9.17e-01
PI-3K cascade:FGFR2	22	9.45e-01	9.62e-01	0.04680	-0.039800	-2.46e-02	7.46e-01	8.42e-01
Telomere Maintenance	62	4.10e-01	5.70e-01	0.04680	0.019600	-4.24e-02	7.89e-01	5.63e-01
Cytochrome P450 - arranged by substrate type	64	8.91e-01	9.22e-01	0.04660	-0.032600	-3.33e-02	6.51e-01	6.45e-01
RNA Polymerase I Promoter Clearance	46	8.46e-01	8.96e-01	0.04650	-0.042500	-1.88e-02	6.18e-01	8.25e-01
Downregulation of ERBB2 signaling	28	7.74e-01	8.48e-01	0.04640	-0.000986	4.64e-02	9.93e-01	6.71e-01
Signaling by NOTCH	182	6.74e-02	1.96e-01	0.04610	-0.039400	2.40e-02	3.59e-01	5.76e-01
LDL clearance	19	8.33e-01	8.84e-01	0.04610	-0.046000	3.03e-03	7.29e-01	9.82e-01
Interleukin-12 family signaling	53	8.49e-01	8.96e-01	0.04580	-0.020600	-4.09e-02	7.95e-01	6.06e-01
Glucose metabolism	87	8.20e-01	8.75e-01	0.04550	-0.024900	-3.80e-02	6.88e-01	5.40e-01
Heme degradation	16	9.64e-01	9.73e-01	0.04460	-0.037800	-2.37e-02	7.94e-01	8.70e-01
RNA Polymerase II Transcription	1284	1.04e-01	2.59e-01	0.04460	-0.027400	-3.52e-02	9.78e-02	3.34e-02
Maturation of nucleoprotein 9694631	15	8.78e-01	9.12e-01	0.04440	0.002060	-4.44e-02	9.89e-01	7.66e-01
Cargo trafficking to the periciliary membrane	49	5.47e-01	6.80e-01	0.04330	-0.039400	1.80e-02	6.33e-01	8.28e-01
Activated NOTCH1 Transmits Signal to the Nucleus	30	9.04e-01	9.33e-01	0.04330	0.016500	4.00e-02	8.76e-01	7.04e-01
Diseases of mitotic cell cycle	37	7.60e-01	8.40e-01	0.04280	-0.000397	-4.28e-02	9.97e-01	6.52e-01
Cellular responses to stimuli	696	3.64e-01	5.32e-01	0.04220	0.030500	2.91e-02	1.69e-01	1.89e-01
Nuclear Events (kinase and transcription factor activation)	60	5.26e-01	6.62e-01	0.04210	0.013200	-3.99e-02	8.59e-01	5.92e-01
Cellular responses to stress	682	3.78e-01	5.41e-01	0.04190	0.029500	2.98e-02	1.88e-01	1.84e-01
MAPK1/MAPK3 signaling	270	1.19e-01	2.80e-01	0.04160	-0.041500	3.17e-03	2.40e-01	9.29e-01
RAF/MAP kinase cascade	264	1.29e-01	2.95e-01	0.04140	-0.041300	3.00e-03	2.48e-01	9.33e-01
Signaling by FGFR	85	4.01e-01	5.61e-01	0.04110	0.038000	-1.55e-02	5.44e-01	8.05e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	41	9.41e-01	9.59e-01	0.04090	0.031300	2.63e-02	7.29e-01	7.70e-01
Amyloid fiber formation	53	9.10e-01	9.38e-01	0.04030	0.022200	3.37e-02	7.79e-01	6.72e-01
FGFR3 ligand binding and activation	12	8.77e-01	9.12e-01	0.04030	-0.035900	1.81e-02	8.29e-01	9.13e-01
FGFR3c ligand binding and activation	12	8.77e-01	9.12e-01	0.04030	-0.035900	1.81e-02	8.29e-01	9.13e-01
Cell recruitment (pro-inflammatory response)	25	8.20e-01	8.75e-01	0.04010	0.005160	-3.98e-02	9.64e-01	7.31e-01
Purinergic signaling in leishmaniasis infection	25	8.20e-01	8.75e-01	0.04010	0.005160	-3.98e-02	9.64e-01	7.31e-01
Signaling by the B Cell Receptor (BCR)	105	8.63e-01	9.07e-01	0.04000	0.025900	3.05e-02	6.46e-01	5.89e-01
Dual incision in TC-NER	63	5.94e-01	7.17e-01	0.04000	0.039400	-6.73e-03	5.88e-01	9.26e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	7.98e-01	8.63e-01	0.03970	-0.039700	7.30e-04	6.89e-01	9.94e-01
Toll Like Receptor 3 (TLR3) Cascade	99	7.98e-01	8.63e-01	0.03970	-0.035300	-1.80e-02	5.44e-01	7.56e-01
Other interleukin signaling	24	9.49e-01	9.62e-01	0.03960	-0.035000	-1.85e-02	7.67e-01	8.75e-01
FOXO-mediated transcription of cell cycle genes	16	8.63e-01	9.07e-01	0.03930	-0.037500	1.18e-02	7.95e-01	9.35e-01
TCF dependent signaling in response to WNT	168	1.51e-01	3.31e-01	0.03920	-0.027900	2.75e-02	5.32e-01	5.38e-01
Biological oxidations	213	4.67e-01	6.20e-01	0.03890	-0.010700	-3.74e-02	7.87e-01	3.46e-01
RAB geranylgeranylation	57	5.70e-01	7.00e-01	0.03840	0.017000	-3.44e-02	8.24e-01	6.53e-01
DNA Double Strand Break Response	42	9.47e-01	9.62e-01	0.03800	0.029400	2.41e-02	7.41e-01	7.87e-01
Downstream signaling of activated FGFR1	31	8.65e-01	9.07e-01	0.03750	0.004510	3.72e-02	9.65e-01	7.20e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	25	8.30e-01	8.83e-01	0.03640	0.008770	-3.54e-02	9.39e-01	7.60e-01
Interleukin-20 family signaling	24	8.77e-01	9.12e-01	0.03640	-0.036400	2.79e-04	7.58e-01	9.98e-01
Fc epsilon receptor (FCERI) signaling	126	3.94e-01	5.55e-01	0.03610	-0.009050	3.50e-02	8.61e-01	4.98e-01
Cellular response to heat stress	95	7.18e-01	8.10e-01	0.03610	0.035200	8.06e-03	5.53e-01	8.92e-01
Oncogene Induced Senescence	35	8.80e-01	9.14e-01	0.03600	0.007100	3.52e-02	9.42e-01	7.18e-01
Vitamin B5 (pantothenate) metabolism	16	8.73e-01	9.12e-01	0.03430	0.027300	-2.07e-02	8.50e-01	8.86e-01
Interleukin-12 signaling	43	8.75e-01	9.12e-01	0.03420	-0.007730	-3.33e-02	9.30e-01	7.05e-01
Aflatoxin activation and detoxification	19	9.75e-01	9.81e-01	0.03400	-0.028800	-1.80e-02	8.28e-01	8.92e-01
Acyl chain remodelling of PI	16	9.84e-01	9.88e-01	0.03400	0.025200	2.28e-02	8.61e-01	8.75e-01
SUMOylation of DNA replication proteins	44	7.17e-01	8.10e-01	0.03370	0.014600	-3.04e-02	8.67e-01	7.27e-01
Nuclear events stimulated by ALK signaling in cancer	18	8.68e-01	9.09e-01	0.03320	0.018700	-2.74e-02	8.91e-01	8.40e-01
Purine salvage	12	9.21e-01	9.43e-01	0.03180	-0.028200	1.47e-02	8.65e-01	9.30e-01
Telomere Extension By Telomerase	22	9.66e-01	9.74e-01	0.03160	-0.028600	-1.36e-02	8.16e-01	9.12e-01
SARS-CoV-2 Infection	276	6.37e-01	7.48e-01	0.03070	-0.012000	-2.83e-02	7.31e-01	4.18e-01
Phospholipase C-mediated cascade; FGFR4	14	9.83e-01	9.87e-01	0.03050	0.026500	1.51e-02	8.64e-01	9.22e-01
Triglyceride biosynthesis	13	9.18e-01	9.42e-01	0.02990	-0.021700	2.05e-02	8.92e-01	8.98e-01
Apoptosis	164	6.48e-01	7.57e-01	0.02970	0.005010	2.93e-02	9.12e-01	5.17e-01
Infectious disease	830	4.89e-01	6.38e-01	0.02970	-0.017300	-2.41e-02	3.97e-01	2.36e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	110	8.13e-01	8.71e-01	0.02940	-0.009090	-2.80e-02	8.69e-01	6.12e-01
M Phase	335	2.57e-01	4.42e-01	0.02930	0.003070	-2.92e-02	9.23e-01	3.59e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	8.75e-01	9.12e-01	0.02930	0.000949	-2.93e-02	9.92e-01	7.61e-01
WNT ligand biogenesis and trafficking	25	8.75e-01	9.12e-01	0.02900	0.026900	-1.07e-02	8.16e-01	9.26e-01
Reversible hydration of carbon dioxide	11	9.37e-01	9.57e-01	0.02840	-0.020000	2.01e-02	9.08e-01	9.08e-01
Signaling by EGFR in Cancer	25	9.80e-01	9.85e-01	0.02800	-0.015900	-2.31e-02	8.91e-01	8.41e-01
Iron uptake and transport	57	8.74e-01	9.12e-01	0.02790	-0.004600	-2.75e-02	9.52e-01	7.19e-01
Cytokine Signaling in Immune system	670	3.63e-01	5.31e-01	0.02740	0.009060	2.59e-02	6.89e-01	2.52e-01
Phase I - Functionalization of compounds	100	8.95e-01	9.26e-01	0.02690	0.024200	1.18e-02	6.76e-01	8.39e-01
Complement cascade	56	7.73e-01	8.48e-01	0.02500	-0.016600	1.87e-02	8.29e-01	8.09e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	15	9.46e-01	9.62e-01	0.02470	0.023400	-7.84e-03	8.75e-01	9.58e-01
Signaling by Interleukins	434	2.51e-01	4.38e-01	0.02390	-0.005850	2.32e-02	8.34e-01	4.07e-01
FGFR4 ligand binding and activation	13	9.61e-01	9.72e-01	0.02330	0.022600	-5.72e-03	8.88e-01	9.72e-01
Cyclin D associated events in G1	46	8.87e-01	9.20e-01	0.02320	0.023100	-2.63e-03	7.87e-01	9.75e-01
G1 Phase	46	8.87e-01	9.20e-01	0.02320	0.023100	-2.63e-03	7.87e-01	9.75e-01
EGFR downregulation	30	9.48e-01	9.62e-01	0.02270	-0.002290	-2.26e-02	9.83e-01	8.31e-01
NOTCH2 intracellular domain regulates transcription	11	9.95e-01	9.97e-01	0.02140	0.016800	1.32e-02	9.23e-01	9.40e-01
Carboxyterminal post-translational modifications of tubulin	40	8.98e-01	9.28e-01	0.01920	0.014500	-1.25e-02	8.74e-01	8.91e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	9.58e-01	9.70e-01	0.01780	-0.015800	8.10e-03	9.03e-01	9.50e-01
Signaling by FGFR4	40	9.29e-01	9.50e-01	0.01770	0.005040	-1.69e-02	9.56e-01	8.53e-01
Signaling by FGFR3	39	9.89e-01	9.91e-01	0.01670	-0.013400	-9.89e-03	8.85e-01	9.15e-01
Signaling by FGFR2 in disease	42	9.47e-01	9.62e-01	0.01320	0.009700	-8.99e-03	9.13e-01	9.20e-01
Signaling by FGFR1	49	9.82e-01	9.86e-01	0.01320	0.012500	4.20e-03	8.79e-01	9.59e-01
Deubiquitination	226	8.00e-01	8.63e-01	0.01320	0.003440	-1.27e-02	9.29e-01	7.42e-01
Positive epigenetic regulation of rRNA expression	43	9.71e-01	9.77e-01	0.01230	0.000920	-1.23e-02	9.92e-01	8.89e-01
Keratinization	213	9.59e-01	9.70e-01	0.01160	-0.010400	-5.22e-03	7.94e-01	8.95e-01
Glycogen synthesis	13	9.89e-01	9.91e-01	0.01090	0.008260	-7.03e-03	9.59e-01	9.65e-01
Formation of the cornified envelope	73	9.76e-01	9.82e-01	0.00977	0.000970	9.73e-03	9.89e-01	8.86e-01
Regulation of Complement cascade	45	9.97e-01	9.98e-01	0.00832	-0.005530	-6.21e-03	9.49e-01	9.43e-01
Programmed Cell Death	192	9.29e-01	9.50e-01	0.00727	-0.004700	5.54e-03	9.10e-01	8.95e-01
Hormone ligand-binding receptors	13	9.99e-01	9.99e-01	0.00722	0.003780	6.15e-03	9.81e-01	9.69e-01

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Detailed Gene set reports

Activation of RAC1

Activation of RAC1

metric	value
setSize	11
pMANOVA	0.000162
p.adjustMANOVA	0.00161
s.dist	0.931
s.t	-0.727
s.fry	-0.581
p.t	2.94e-05
p.fry	0.00085

Top 20 genes

Gene	t	fry
SLIT2	-21111.5	-20541
RAC1	-19561.5	-19996
SOS2	-19572.5	-19791
ROBO1	-19843.5	-19372
PAK2	-20027.5	-17613
NCK1	-16385.5	-17538
SOS1	-18542.5	-13991
NCK2	-19331.5	-13243
PAK6	-13168.5	-16106
PAK1	-16158.5	-11852
PAK4	-11411.5	-8352

Click HERE to show all gene set members

All member genes

	t	fry
NCK1	-16385.5	-17538
NCK2	-19331.5	-13243
PAK1	-16158.5	-11852
PAK2	-20027.5	-17613
PAK4	-11411.5	-8352
PAK6	-13168.5	-16106
RAC1	-19561.5	-19996
ROBO1	-19843.5	-19372
SLIT2	-21111.5	-20541
SOS1	-18542.5	-13991
SOS2	-19572.5	-19791

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Eicosanoids

Eicosanoids

metric	value
setSize	12
pMANOVA	0.000249
p.adjustMANOVA	0.00228
s.dist	0.909
s.t	0.633
s.fry	0.653
p.t	0.000146
p.fry	9.03e-05

Top 20 genes

Gene	t	fry
CYP8B1	3770.5	3395
CYP4A11	3492.5	3218
CYP4A22	3119.5	2309
CYP4F2	3048.5	2274
CYP4F8	2468.5	1177

Click HERE to show all gene set members

All member genes

	t	fry
CYP4A11	3492.5	3218
CYP4A22	3119.5	2309
CYP4B1	1486.5	-3641
CYP4F11	-1368.5	218
CYP4F12	-1486.5	-533
CYP4F2	3048.5	2274
CYP4F22	2162.5	-2229
CYP4F3	508.5	-227
CYP4F8	2468.5	1177
CYP8B1	3770.5	3395
PTGIS	-1526.5	-390
TBXAS1	-18505.5	-9782

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Apoptotic cleavage of cell adhesion proteins

Apoptotic cleavage of cell adhesion proteins

metric	value
setSize	11
pMANOVA	0.00321
p.adjustMANOVA	0.0194
s.dist	0.788
s.t	-0.575
s.fry	-0.539
p.t	0.000967
p.fry	0.00197

Top 20 genes

Gene	t	fry
TJP1	-19619.5	-21087
OCLN	-18351.5	-20081
DSG2	-17355.5	-19023
DSG1	-17822.5	-17889
DSP	-14463.5	-19367
CASP3	-13380.5	-20877
CTNNB1	-18325.5	-11591
TJP2	-16776.5	-11660
DSG3	-13748.5	-13268
CDH1	-14860.5	-10617
PKP1	-8777.5	-6973

Click HERE to show all gene set members

All member genes

	t	fry
CASP3	-13380.5	-20877
CDH1	-14860.5	-10617
CTNNB1	-18325.5	-11591
DSG1	-17822.5	-17889
DSG2	-17355.5	-19023
DSG3	-13748.5	-13268
DSP	-14463.5	-19367
OCLN	-18351.5	-20081
PKP1	-8777.5	-6973
TJP1	-19619.5	-21087
TJP2	-16776.5	-11660

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Carnitine metabolism

Carnitine metabolism

metric	value
setSize	11
pMANOVA	0.012
p.adjustMANOVA	0.0549
s.dist	0.682
s.t	-0.514
s.fry	-0.449
p.t	0.00318
p.fry	0.00997

Top 20 genes

Gene	t	fry
SLC22A5	-15959.5	-19067
CPT1A	-20801.5	-14211
CPT1B	-21079.5	-13288
CPT2	-18582.5	-13451
RXRA	-19898.5	-11950
PRKAA2	-10230.5	-21275
PRKAG2	-20773.5	-9837
PPARD	-9705.5	-16076
SLC25A20	-7165.5	-18430
PRKAB2	-9570.5	-13279
THRSP	-11089.5	-8834

Click HERE to show all gene set members

All member genes

	t	fry
CPT1A	-20801.5	-14211
CPT1B	-21079.5	-13288
CPT2	-18582.5	-13451
PPARD	-9705.5	-16076
PRKAA2	-10230.5	-21275
PRKAB2	-9570.5	-13279
PRKAG2	-20773.5	-9837
RXRA	-19898.5	-11950
SLC22A5	-15959.5	-19067
SLC25A20	-7165.5	-18430
THRSP	-11089.5	-8834

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SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery

metric	value
setSize	34
pMANOVA	1.72e-07
p.adjustMANOVA	5.55e-06
s.dist	0.674
s.t	0.548
s.fry	0.392
p.t	3.17e-08
p.fry	7.52e-05

Top 20 genes

Gene	t	fry
RPS12	4442.5	3999
HNRNPA1	4413.5	3857
RPS27A	3945.5	3331
RPS19	3500.5	3394
RPS11	1998.5	2177
RPS29	2499.5	1625
RPS27L	1726.5	1431
RPS18	2312.5	1041
RPS23	1573.5	1255
EEF1A1	1529.5	1261
RPS21	1289.5	1172
RPS27	795.5	1318
RPSA	1312.5	644
FAU	1029.5	358
RPS17	0.5	594

Click HERE to show all gene set members

All member genes

	t	fry
EEF1A1	1529.5	1261
FAU	1029.5	358
HNRNPA1	4413.5	3857
RPS10	-3622.5	-8002
RPS11	1998.5	2177
RPS12	4442.5	3999
RPS13	2859.5	-3324
RPS14	-3250.5	-11554
RPS15	-5736.5	-13164
RPS15A	-5843.5	-3391
RPS16	-2274.5	1705
RPS17	0.5	594
RPS18	2312.5	1041
RPS19	3500.5	3394
RPS2	-2384.5	-1176
RPS20	-2002.5	-1705
RPS21	1289.5	1172
RPS23	1573.5	1255
RPS24	-7343.5	-12237
RPS25	2765.5	-5634
RPS26	-7549.5	-10733
RPS27	795.5	1318
RPS27A	3945.5	3331
RPS27L	1726.5	1431
RPS28	-12309.5	-20224
RPS29	2499.5	1625
RPS3	-2501.5	-968
RPS3A	-1000.5	-746
RPS5	2320.5	-19598
RPS6	-8194.5	-8979
RPS7	-6542.5	-9140
RPS8	-5881.5	-5504
RPS9	-9374.5	-19042
RPSA	1312.5	644

---

---

ALK mutants bind TKIs

ALK mutants bind TKIs

metric	value
setSize	12
pMANOVA	0.0133
p.adjustMANOVA	0.0594
s.dist	0.65
s.t	-0.434
s.fry	-0.483
p.t	0.00922
p.fry	0.00373

Top 20 genes

Gene	t	fry
PRKAR1A	-19170.5	-20497
BIRC6	-20382.5	-18142
CLTC	-18899.5	-19383
EML4	-19302.5	-18542
STRN	-20987.5	-16680
FN1	-20093.5	-16817
HIP1	-17700.5	-16731
BCL11A	-12034.5	-20465
NPM1	-9728.5	-20459
EIF2AK3	-9154.5	-12297
ALK	-4055.5	-2707

Click HERE to show all gene set members

All member genes

	t	fry
ALK	-4055.5	-2707
BCL11A	-12034.5	-20465
BIRC6	-20382.5	-18142
CLTC	-18899.5	-19383
EIF2AK3	-9154.5	-12297
EML4	-19302.5	-18542
FN1	-20093.5	-16817
HIP1	-17700.5	-16731
NPM1	-9728.5	-20459
PPM1B	3941.5	3138
PRKAR1A	-19170.5	-20497
STRN	-20987.5	-16680

---

---

Regulation of TP53 Activity through Association with Co-factors

Regulation of TP53 Activity through Association with Co-factors

metric	value
setSize	14
pMANOVA	2.16e-05
p.adjustMANOVA	0.000356
s.dist	0.626
s.t	-0.586
s.fry	-0.219
p.t	0.000145
p.fry	0.155

Top 20 genes

Gene	t	fry
PHF20	-20009.5	-17027
TP63	-20827.5	-15497
PPP1R13L	-16052.5	-19321
AKT3	-21089.5	-13946
POU4F2	-14755.5	-16059
ZNF385A	-17652.5	-13221
PPP1R13B	-18143.5	-11796
BANP	-21049.5	-9834
AKT1	-19450.5	-9989
TP53BP2	-14123.5	-13119
AKT2	-18330.5	-9830
TP73	-13541.5	-6349
TP53	-4491.5	-4353
POU4F1	-3383.5	-1626

Click HERE to show all gene set members

All member genes

	t	fry
AKT1	-19450.5	-9989
AKT2	-18330.5	-9830
AKT3	-21089.5	-13946
BANP	-21049.5	-9834
PHF20	-20009.5	-17027
POU4F1	-3383.5	-1626
POU4F2	-14755.5	-16059
PPP1R13B	-18143.5	-11796
PPP1R13L	-16052.5	-19321
TP53	-4491.5	-4353
TP53BP2	-14123.5	-13119
TP63	-20827.5	-15497
TP73	-13541.5	-6349
ZNF385A	-17652.5	-13221

---

---

CASP8 activity is inhibited

CASP8 activity is inhibited

metric	value
setSize	11
pMANOVA	0.02
p.adjustMANOVA	0.0818
s.dist	0.601
s.t	0.355
s.fry	0.484
p.t	0.0414
p.fry	0.00541

Top 20 genes

Gene	t	fry
FASLG	4190.5	2427
CASP8	2701.5	3200

Click HERE to show all gene set members

All member genes

	t	fry
CASP8	2701.5	3200
CFLAR	-1032.5	197
FADD	-4485.5	-4513
FAS	-639.5	23
FASLG	4190.5	2427
RIPK1	-15377.5	-5755
TNFRSF10A	-9871.5	-10737
TNFRSF10B	-1811.5	-1082
TNFSF10	-3190.5	-2114
TRADD	-6653.5	-6106
TRAF2	-5778.5	-3210

---

---

Dimerization of procaspase-8

Dimerization of procaspase-8

metric	value
setSize	11
pMANOVA	0.02
p.adjustMANOVA	0.0818
s.dist	0.601
s.t	0.355
s.fry	0.484
p.t	0.0414
p.fry	0.00541

Top 20 genes

Gene	t	fry
FASLG	4190.5	2427
CASP8	2701.5	3200

Click HERE to show all gene set members

All member genes

	t	fry
CASP8	2701.5	3200
CFLAR	-1032.5	197
FADD	-4485.5	-4513
FAS	-639.5	23
FASLG	4190.5	2427
RIPK1	-15377.5	-5755
TNFRSF10A	-9871.5	-10737
TNFRSF10B	-1811.5	-1082
TNFSF10	-3190.5	-2114
TRADD	-6653.5	-6106
TRAF2	-5778.5	-3210

---

---

Regulation by c-FLIP

Regulation by c-FLIP

metric	value
setSize	11
pMANOVA	0.02
p.adjustMANOVA	0.0818
s.dist	0.601
s.t	0.355
s.fry	0.484
p.t	0.0414
p.fry	0.00541

Top 20 genes

Gene	t	fry
FASLG	4190.5	2427
CASP8	2701.5	3200

Click HERE to show all gene set members

All member genes

	t	fry
CASP8	2701.5	3200
CFLAR	-1032.5	197
FADD	-4485.5	-4513
FAS	-639.5	23
FASLG	4190.5	2427
RIPK1	-15377.5	-5755
TNFRSF10A	-9871.5	-10737
TNFRSF10B	-1811.5	-1082
TNFSF10	-3190.5	-2114
TRADD	-6653.5	-6106
TRAF2	-5778.5	-3210

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	84
pMANOVA	6.09e-12
p.adjustMANOVA	5.89e-10
s.dist	0.583
s.t	0.453
s.fry	0.367
p.t	6.72e-13
p.fry	5.92e-09

Top 20 genes

Gene	t	fry
RPS12	4442.5	3999
RPL35A	4081.5	3721
RPL34	3994.5	3529
RPL4	3769.5	3490
RPS27A	3945.5	3331
RPL41	4003.5	3262
RPL28	3929.5	3194
RPS19	3500.5	3394
RPL23	2913.5	3066
RPL32	2638.5	2750
RPS11	1998.5	2177
RPL35	1466.5	2921
RPS29	2499.5	1625
RPL39L	2140.5	1353
RPS27L	1726.5	1431
RPS18	2312.5	1041
RPS23	1573.5	1255
EEF1A1	1529.5	1261
RPS21	1289.5	1172
RPS27	795.5	1318

Click HERE to show all gene set members

All member genes

	t	fry
EEF1A1	1529.5	1261.0
EEF2	-12191.5	-13156.0
FAU	1029.5	358.0
RPL10A	-2906.5	-3724.0
RPL10L	-16334.5	-11519.0
RPL11	-8109.5	-16403.0
RPL12	-2240.5	-714.0
RPL13	571.5	-223.0
RPL13A	-7169.0	-6194.5
RPL14	-2303.5	2151.0
RPL15	-868.5	261.0
RPL17	1840.5	-4757.0
RPL18	-586.5	499.0
RPL18A	-979.5	-494.0
RPL19	-7251.5	-11176.0
RPL21	-4831.5	-9326.0
RPL22	-5310.5	-7738.0
RPL22L1	-11556.5	-12495.0
RPL23	2913.5	3066.0
RPL23A	626.5	-1277.0
RPL24	-5578.5	-8548.0
RPL26	-1432.5	-4386.0
RPL26L1	-7084.5	-16944.0
RPL27	-1532.5	-406.0
RPL27A	-1524.5	1726.0
RPL28	3929.5	3194.0
RPL29	-2277.5	-3035.0
RPL3	-4092.5	-11340.0
RPL30	-528.5	-248.0
RPL31	-13148.5	-13322.0
RPL32	2638.5	2750.0
RPL34	3994.5	3529.0
RPL35	1466.5	2921.0
RPL35A	4081.5	3721.0
RPL36	-2623.5	-2663.0
RPL36AL	-5460.5	-4233.0
RPL37	-3994.5	-3984.0
RPL37A	-4154.5	-2715.0
RPL38	-15057.5	-18437.0
RPL39L	2140.5	1353.0
RPL3L	-11023.5	-3306.0
RPL4	3769.5	3490.0
RPL41	4003.5	3262.0
RPL5	-2029.5	-7354.0
RPL6	-8585.5	-18755.0
RPL7	-2241.5	1376.0
RPL7A	-2123.5	-1243.0
RPL8	-1223.5	-1317.0
RPL9	-1192.5	-3922.0
RPLP0	-2082.5	255.0
RPLP1	-10891.5	-17514.0
RPLP2	-1960.5	1779.0
RPS10	-3622.5	-8002.0
RPS11	1998.5	2177.0
RPS12	4442.5	3999.0
RPS13	2859.5	-3324.0
RPS14	-3250.5	-11554.0
RPS15	-5736.5	-13164.0
RPS15A	-5843.5	-3391.0
RPS16	-2274.5	1705.0
RPS17	0.5	594.0
RPS18	2312.5	1041.0
RPS19	3500.5	3394.0
RPS2	-2384.5	-1176.0
RPS20	-2002.5	-1705.0
RPS21	1289.5	1172.0
RPS23	1573.5	1255.0
RPS24	-7343.5	-12237.0
RPS25	2765.5	-5634.0
RPS26	-7549.5	-10733.0
RPS27	795.5	1318.0
RPS27A	3945.5	3331.0
RPS27L	1726.5	1431.0
RPS28	-12309.5	-20224.0
RPS29	2499.5	1625.0
RPS3	-2501.5	-968.0
RPS3A	-1000.5	-746.0
RPS5	2320.5	-19598.0
RPS6	-8194.5	-8979.0
RPS7	-6542.5	-9140.0
RPS8	-5881.5	-5504.0
RPS9	-9374.5	-19042.0
RPSA	1312.5	644.0
UBA52	-3287.5	-1797.0

---

---

Pexophagy

Pexophagy

metric	value
setSize	11
pMANOVA	0.0434
p.adjustMANOVA	0.143
s.dist	0.583
s.t	0.402
s.fry	0.423
p.t	0.021
p.fry	0.0152

Top 20 genes

Gene	t	fry
UBB	4311.5	3147
RPS27A	3945.5	3331
ATM	3525.5	3131
NBR1	3496.5	2797

Click HERE to show all gene set members

All member genes

	t	fry
ATM	3525.5	3131
EPAS1	-16392.5	-9289
MAP1LC3B	-10433.5	-16927
NBR1	3496.5	2797
PEX5	-7205.5	-4343
RPS27A	3945.5	3331
SQSTM1	-9696.5	-10280
UBA52	-3287.5	-1797
UBB	4311.5	3147
UBC	815.5	-1813
USP30	-4420.5	-4355

---

---

MET activates PTK2 signaling

MET activates PTK2 signaling

metric	value
setSize	18
pMANOVA	9.21e-05
p.adjustMANOVA	0.001
s.dist	0.583
s.t	-0.523
s.fry	-0.257
p.t	0.000121
p.fry	0.0594

Top 20 genes

Gene	t	fry
LAMA2	-21075.5	-19859
LAMA1	-19671.5	-21161
MET	-20519.5	-20056
ITGA2	-19036.5	-21139
LAMB1	-17906.5	-19710
LAMA4	-20680.5	-15139
LAMC1	-16806.5	-18020
PTK2	-20496.5	-14294
HGF	-19420.5	-13401
ITGB1	-14247.5	-9885
SRC	-17084.5	-8079
LAMB2	-16883.5	-7157
LAMC3	-11636.5	-8837
LAMC2	-11001.5	-7945
LAMA5	-14590.5	-5816
LAMB3	-11202.5	-7089
LAMA3	-1258.5	-460

Click HERE to show all gene set members

All member genes

	t	fry
HGF	-19420.5	-13401
ITGA2	-19036.5	-21139
ITGA3	1516.5	1219
ITGB1	-14247.5	-9885
LAMA1	-19671.5	-21161
LAMA2	-21075.5	-19859
LAMA3	-1258.5	-460
LAMA4	-20680.5	-15139
LAMA5	-14590.5	-5816
LAMB1	-17906.5	-19710
LAMB2	-16883.5	-7157
LAMB3	-11202.5	-7089
LAMC1	-16806.5	-18020
LAMC2	-11001.5	-7945
LAMC3	-11636.5	-8837
MET	-20519.5	-20056
PTK2	-20496.5	-14294
SRC	-17084.5	-8079

---

---

VEGFR2 mediated vascular permeability

VEGFR2 mediated vascular permeability

metric	value
setSize	26
pMANOVA	7.32e-07
p.adjustMANOVA	2.1e-05
s.dist	0.571
s.t	-0.521
s.fry	-0.233
p.t	4.16e-06
p.fry	0.0393

Top 20 genes

Gene	t	fry
RAC1	-19561.5	-19996
VAV3	-20833.5	-16998
PAK2	-20027.5	-17613
MAPKAP1	-21110.5	-14431
AKT3	-21089.5	-13946
RICTOR	-19090.5	-15027
CTNND1	-20063.5	-14104
THEM4	-16480.5	-14720
PRR5	-17826.5	-12135
CTNNB1	-18325.5	-11591
MTOR	-20495.5	-10213
CTNNA1	-18965.5	-10679
AKT1	-19450.5	-9989
PAK1	-16158.5	-11852
JUP	-13346.5	-14340
AKT2	-18330.5	-9830
MLST8	-12571.5	-14177
CDH5	-18428.5	-9436
VAV2	-14440.5	-6869
PDPK1	-13556.5	-6761

Click HERE to show all gene set members

All member genes

	t	fry
AKT1	-19450.5	-9989
AKT2	-18330.5	-9830
AKT3	-21089.5	-13946
CALM1	-3142.5	-11117
CAV1	-7586.5	-8420
CDH5	-18428.5	-9436
CTNNA1	-18965.5	-10679
CTNNB1	-18325.5	-11591
CTNND1	-20063.5	-14104
HSP90AA1	-5283.5	-7200
JUP	-13346.5	-14340
MAPKAP1	-21110.5	-14431
MLST8	-12571.5	-14177
MTOR	-20495.5	-10213
NOS3	-5882.5	-2304
PAK1	-16158.5	-11852
PAK2	-20027.5	-17613
PDPK1	-13556.5	-6761
PRR5	-17826.5	-12135
RAC1	-19561.5	-19996
RICTOR	-19090.5	-15027
THEM4	-16480.5	-14720
TRIB3	-4166.5	-7350
VAV1	-5961.5	-14346
VAV2	-14440.5	-6869
VAV3	-20833.5	-16998

---

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	88
pMANOVA	7.06e-12
p.adjustMANOVA	6.06e-10
s.dist	0.569
s.t	0.441
s.fry	0.359
p.t	7.86e-13
p.fry	5.74e-09

Top 20 genes

Gene	t	fry
RPS12	4442.5	3999
EEF1B2	4316.5	4109
RPL35A	4081.5	3721
RPL34	3994.5	3529
RPL4	3769.5	3490
RPS27A	3945.5	3331
RPL41	4003.5	3262
RPL28	3929.5	3194
RPS19	3500.5	3394
RPL23	2913.5	3066
RPL32	2638.5	2750
RPS11	1998.5	2177
RPL35	1466.5	2921
RPS29	2499.5	1625
RPL39L	2140.5	1353
RPS27L	1726.5	1431
RPS18	2312.5	1041
RPS23	1573.5	1255
EEF1A1	1529.5	1261
RPS21	1289.5	1172

Click HERE to show all gene set members

All member genes

	t	fry
EEF1A1	1529.5	1261.0
EEF1A2	-10182.5	-13814.0
EEF1B2	4316.5	4109.0
EEF1D	-15346.5	-11187.0
EEF1G	-2344.5	-4457.0
EEF2	-12191.5	-13156.0
FAU	1029.5	358.0
RPL10A	-2906.5	-3724.0
RPL10L	-16334.5	-11519.0
RPL11	-8109.5	-16403.0
RPL12	-2240.5	-714.0
RPL13	571.5	-223.0
RPL13A	-7169.0	-6194.5
RPL14	-2303.5	2151.0
RPL15	-868.5	261.0
RPL17	1840.5	-4757.0
RPL18	-586.5	499.0
RPL18A	-979.5	-494.0
RPL19	-7251.5	-11176.0
RPL21	-4831.5	-9326.0
RPL22	-5310.5	-7738.0
RPL22L1	-11556.5	-12495.0
RPL23	2913.5	3066.0
RPL23A	626.5	-1277.0
RPL24	-5578.5	-8548.0
RPL26	-1432.5	-4386.0
RPL26L1	-7084.5	-16944.0
RPL27	-1532.5	-406.0
RPL27A	-1524.5	1726.0
RPL28	3929.5	3194.0
RPL29	-2277.5	-3035.0
RPL3	-4092.5	-11340.0
RPL30	-528.5	-248.0
RPL31	-13148.5	-13322.0
RPL32	2638.5	2750.0
RPL34	3994.5	3529.0
RPL35	1466.5	2921.0
RPL35A	4081.5	3721.0
RPL36	-2623.5	-2663.0
RPL36AL	-5460.5	-4233.0
RPL37	-3994.5	-3984.0
RPL37A	-4154.5	-2715.0
RPL38	-15057.5	-18437.0
RPL39L	2140.5	1353.0
RPL3L	-11023.5	-3306.0
RPL4	3769.5	3490.0
RPL41	4003.5	3262.0
RPL5	-2029.5	-7354.0
RPL6	-8585.5	-18755.0
RPL7	-2241.5	1376.0
RPL7A	-2123.5	-1243.0
RPL8	-1223.5	-1317.0
RPL9	-1192.5	-3922.0
RPLP0	-2082.5	255.0
RPLP1	-10891.5	-17514.0
RPLP2	-1960.5	1779.0
RPS10	-3622.5	-8002.0
RPS11	1998.5	2177.0
RPS12	4442.5	3999.0
RPS13	2859.5	-3324.0
RPS14	-3250.5	-11554.0
RPS15	-5736.5	-13164.0
RPS15A	-5843.5	-3391.0
RPS16	-2274.5	1705.0
RPS17	0.5	594.0
RPS18	2312.5	1041.0
RPS19	3500.5	3394.0
RPS2	-2384.5	-1176.0
RPS20	-2002.5	-1705.0
RPS21	1289.5	1172.0
RPS23	1573.5	1255.0
RPS24	-7343.5	-12237.0
RPS25	2765.5	-5634.0
RPS26	-7549.5	-10733.0
RPS27	795.5	1318.0
RPS27A	3945.5	3331.0
RPS27L	1726.5	1431.0
RPS28	-12309.5	-20224.0
RPS29	2499.5	1625.0
RPS3	-2501.5	-968.0
RPS3A	-1000.5	-746.0
RPS5	2320.5	-19598.0
RPS6	-8194.5	-8979.0
RPS7	-6542.5	-9140.0
RPS8	-5881.5	-5504.0
RPS9	-9374.5	-19042.0
RPSA	1312.5	644.0
UBA52	-3287.5	-1797.0

---

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

metric	value
setSize	87
pMANOVA	6.72e-12
p.adjustMANOVA	6.06e-10
s.dist	0.567
s.t	0.445
s.fry	0.351
p.t	7.36e-13
p.fry	1.45e-08

Top 20 genes

Gene	t	fry
RPS12	4442.5	3999
RPL35A	4081.5	3721
RPL34	3994.5	3529
RPL4	3769.5	3490
RPS27A	3945.5	3331
RPL41	4003.5	3262
RPL28	3929.5	3194
RPS19	3500.5	3394
RPL23	2913.5	3066
RPL32	2638.5	2750
RPS11	1998.5	2177
RPL35	1466.5	2921
RPS29	2499.5	1625
RPL39L	2140.5	1353
RPS27L	1726.5	1431
RPS18	2312.5	1041
RPS23	1573.5	1255
RPS21	1289.5	1172
RPS27	795.5	1318
RPSA	1312.5	644

Click HERE to show all gene set members

All member genes

	t	fry
APEH	-10345.5	-19705.0
ETF1	-5582.5	-7950.0
FAU	1029.5	358.0
GSPT1	-9077.5	-13937.0
N6AMT1	-1813.5	1608.0
RPL10A	-2906.5	-3724.0
RPL10L	-16334.5	-11519.0
RPL11	-8109.5	-16403.0
RPL12	-2240.5	-714.0
RPL13	571.5	-223.0
RPL13A	-7169.0	-6194.5
RPL14	-2303.5	2151.0
RPL15	-868.5	261.0
RPL17	1840.5	-4757.0
RPL18	-586.5	499.0
RPL18A	-979.5	-494.0
RPL19	-7251.5	-11176.0
RPL21	-4831.5	-9326.0
RPL22	-5310.5	-7738.0
RPL22L1	-11556.5	-12495.0
RPL23	2913.5	3066.0
RPL23A	626.5	-1277.0
RPL24	-5578.5	-8548.0
RPL26	-1432.5	-4386.0
RPL26L1	-7084.5	-16944.0
RPL27	-1532.5	-406.0
RPL27A	-1524.5	1726.0
RPL28	3929.5	3194.0
RPL29	-2277.5	-3035.0
RPL3	-4092.5	-11340.0
RPL30	-528.5	-248.0
RPL31	-13148.5	-13322.0
RPL32	2638.5	2750.0
RPL34	3994.5	3529.0
RPL35	1466.5	2921.0
RPL35A	4081.5	3721.0
RPL36	-2623.5	-2663.0
RPL36AL	-5460.5	-4233.0
RPL37	-3994.5	-3984.0
RPL37A	-4154.5	-2715.0
RPL38	-15057.5	-18437.0
RPL39L	2140.5	1353.0
RPL3L	-11023.5	-3306.0
RPL4	3769.5	3490.0
RPL41	4003.5	3262.0
RPL5	-2029.5	-7354.0
RPL6	-8585.5	-18755.0
RPL7	-2241.5	1376.0
RPL7A	-2123.5	-1243.0
RPL8	-1223.5	-1317.0
RPL9	-1192.5	-3922.0
RPLP0	-2082.5	255.0
RPLP1	-10891.5	-17514.0
RPLP2	-1960.5	1779.0
RPS10	-3622.5	-8002.0
RPS11	1998.5	2177.0
RPS12	4442.5	3999.0
RPS13	2859.5	-3324.0
RPS14	-3250.5	-11554.0
RPS15	-5736.5	-13164.0
RPS15A	-5843.5	-3391.0
RPS16	-2274.5	1705.0
RPS17	0.5	594.0
RPS18	2312.5	1041.0
RPS19	3500.5	3394.0
RPS2	-2384.5	-1176.0
RPS20	-2002.5	-1705.0
RPS21	1289.5	1172.0
RPS23	1573.5	1255.0
RPS24	-7343.5	-12237.0
RPS25	2765.5	-5634.0
RPS26	-7549.5	-10733.0
RPS27	795.5	1318.0
RPS27A	3945.5	3331.0
RPS27L	1726.5	1431.0
RPS28	-12309.5	-20224.0
RPS29	2499.5	1625.0
RPS3	-2501.5	-968.0
RPS3A	-1000.5	-746.0
RPS5	2320.5	-19598.0
RPS6	-8194.5	-8979.0
RPS7	-6542.5	-9140.0
RPS8	-5881.5	-5504.0
RPS9	-9374.5	-19042.0
RPSA	1312.5	644.0
TRMT112	-1227.5	-1630.0
UBA52	-3287.5	-1797.0

---

---

RHOJ GTPase cycle

RHOJ GTPase cycle

metric	value
setSize	51
pMANOVA	4.06e-07
p.adjustMANOVA	1.23e-05
s.dist	0.56
s.t	-0.439
s.fry	-0.348
p.t	5.79e-08
p.fry	1.72e-05

Top 20 genes

Gene	t	fry
WASL	-20929.5	-21466
ARL13B	-19717.5	-21095
SLC4A7	-21067.5	-19676
DIAPH3	-20663.5	-19745
MPP7	-21180.5	-18047
ARHGAP26	-21198.5	-17516
TFRC	-17108.5	-20892
SYDE1	-18135.5	-19698
PAK2	-20027.5	-17613
FNBP1L	-18950.5	-18454
LAMTOR1	-18152.5	-18881
DOCK8	-18692.5	-18197
GIT2	-18018.5	-18205
GBAS	-16175.5	-19186
TRIO	-21188.5	-14212
ARHGAP32	-20842.5	-14164
GJA1	-14683.5	-19674
CDC42BPA	-19822.5	-13796
ARHGAP21	-16149.5	-16445
VANGL1	-13055.5	-19261

Click HERE to show all gene set members

All member genes

	t	fry
ARHGAP1	-10317.5	-14805
ARHGAP21	-16149.5	-16445
ARHGAP26	-21198.5	-17516
ARHGAP32	-20842.5	-14164
ARHGAP35	-3153.5	-3121
ARHGAP5	-3858.5	-5255
ARHGEF7	-18171.5	-11837
ARL13B	-19717.5	-21095
CAV1	-7586.5	-8420
CDC42	-4538.5	-13348
CDC42BPA	-19822.5	-13796
CDC42BPB	-19879.5	-11419
CDC42EP1	-3340.5	-3348
CPNE8	-12186.5	-16514
DEPDC1B	-3101.5	-3475
DIAPH3	-20663.5	-19745
DOCK8	-18692.5	-18197
FMNL3	-13942.5	-9741
FNBP1	-8008.5	-7792
FNBP1L	-18950.5	-18454
GBAS	-16175.5	-19186
GIT1	-12303.5	-6713
GIT2	-18018.5	-18205
GJA1	-14683.5	-19674
IQGAP3	-17688.5	-13413
JUP	-13346.5	-14340
LAMTOR1	-18152.5	-18881
MPP7	-21180.5	-18047
PAK1	-16158.5	-11852
PAK2	-20027.5	-17613
PAK4	-11411.5	-8352
PIK3R1	-9935.5	-17042
PIK3R2	-12609.5	-7716
PREX1	-18447.5	-12143
RAB7A	-9376.5	-8188
RHOJ	-7464.5	-14350
SCRIB	-17101.5	-8686
SLC1A5	-13995.5	-17539
SLC4A7	-21067.5	-19676
SNAP23	-9166.5	-6320
STEAP3	-11668.5	-6936
STOM	-7645.5	-10518
SYDE1	-18135.5	-19698
TFRC	-17108.5	-20892
TMPO	749.5	-1051
TRIO	-21188.5	-14212
VAMP3	-13326.5	-13476
VANGL1	-13055.5	-19261
WASL	-20929.5	-21466
WIPF2	-9922.5	-10597
WWP2	-20252.5	-9351

---

---

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

metric	value
setSize	14
pMANOVA	0.00694
p.adjustMANOVA	0.036
s.dist	0.56
s.t	-0.471
s.fry	-0.302
p.t	0.00226
p.fry	0.0501

Top 20 genes

Gene	t	fry
RAC1	-19561.5	-19996
DOCK1	-20716.5	-18052
ELMO2	-16403.5	-21375
PXN	-20123.5	-15216
ELMO1	-21093.5	-13408
RHOA	-15562.5	-16422
KRAS	-11842.5	-16612
HRAS	-15820.5	-12286
CRK	-15466.5	-11600
BCAR1	-18392.5	-7345
RASA1	-11299.5	-9903
NRAS	-6371.5	-7675
PTK6	-6393.5	-3890
ARHGAP35	-3153.5	-3121

Click HERE to show all gene set members

All member genes

	t	fry
ARHGAP35	-3153.5	-3121
BCAR1	-18392.5	-7345
CRK	-15466.5	-11600
DOCK1	-20716.5	-18052
ELMO1	-21093.5	-13408
ELMO2	-16403.5	-21375
HRAS	-15820.5	-12286
KRAS	-11842.5	-16612
NRAS	-6371.5	-7675
PTK6	-6393.5	-3890
PXN	-20123.5	-15216
RAC1	-19561.5	-19996
RASA1	-11299.5	-9903
RHOA	-15562.5	-16422

---

---

Competing endogenous RNAs (ceRNAs) regulate PTEN translation

Competing endogenous RNAs (ceRNAs) regulate PTEN translation

metric	value
setSize	16
pMANOVA	0.0154
p.adjustMANOVA	0.0674
s.dist	0.559
s.t	-0.391
s.fry	-0.399
p.t	0.0068
p.fry	0.00567

Top 20 genes

Gene	t	fry
VAPA	-17889.5	-20661
MIR106B	-17874.5	-19492
AGO4	-19034.5	-16955
TNRC6A	-20383.5	-15256
AGO1	-18198.5	-15518
CNOT6L	-13233.5	-20035
MIR19B1	-16542.5	-15595
TNRC6C	-20034.5	-11485
MIR19A	-11680.5	-17303
MIR20A	-10173.5	-17165
MOV10	-10270.5	-15127
AGO3	-11519.5	-9216
MIR17	-6310.5	-10650
TNRC6B	-8673.5	-7031
AGO2	-8596.5	-4508
PTENP1	-4083.5	-6126

Click HERE to show all gene set members

All member genes

	t	fry
AGO1	-18198.5	-15518
AGO2	-8596.5	-4508
AGO3	-11519.5	-9216
AGO4	-19034.5	-16955
CNOT6L	-13233.5	-20035
MIR106B	-17874.5	-19492
MIR17	-6310.5	-10650
MIR19A	-11680.5	-17303
MIR19B1	-16542.5	-15595
MIR20A	-10173.5	-17165
MOV10	-10270.5	-15127
PTENP1	-4083.5	-6126
TNRC6A	-20383.5	-15256
TNRC6B	-8673.5	-7031
TNRC6C	-20034.5	-11485
VAPA	-17889.5	-20661

---

---

Selenocysteine synthesis

Selenocysteine synthesis

metric	value
setSize	87
pMANOVA	2.77e-11
p.adjustMANOVA	2.14e-09
s.dist	0.558
s.t	0.432
s.fry	0.353
p.t	3.19e-12
p.fry	1.28e-08

Top 20 genes

Gene	t	fry
RPS12	4442.5	3999
RPL35A	4081.5	3721
RPL34	3994.5	3529
RPL4	3769.5	3490
RPS27A	3945.5	3331
RPL41	4003.5	3262
RPL28	3929.5	3194
RPS19	3500.5	3394
RPL23	2913.5	3066
RPL32	2638.5	2750
RPS11	1998.5	2177
RPL35	1466.5	2921
RPS29	2499.5	1625
RPL39L	2140.5	1353
RPS27L	1726.5	1431
RPS18	2312.5	1041
RPS23	1573.5	1255
RPS21	1289.5	1172
RPS27	795.5	1318
RPSA	1312.5	644

Click HERE to show all gene set members

All member genes

	t	fry
EEFSEC	-17927.5	-7278.0
FAU	1029.5	358.0
PSTK	-4813.5	-10166.0
RPL10A	-2906.5	-3724.0
RPL10L	-16334.5	-11519.0
RPL11	-8109.5	-16403.0
RPL12	-2240.5	-714.0
RPL13	571.5	-223.0
RPL13A	-7169.0	-6194.5
RPL14	-2303.5	2151.0
RPL15	-868.5	261.0
RPL17	1840.5	-4757.0
RPL18	-586.5	499.0
RPL18A	-979.5	-494.0
RPL19	-7251.5	-11176.0
RPL21	-4831.5	-9326.0
RPL22	-5310.5	-7738.0
RPL22L1	-11556.5	-12495.0
RPL23	2913.5	3066.0
RPL23A	626.5	-1277.0
RPL24	-5578.5	-8548.0
RPL26	-1432.5	-4386.0
RPL26L1	-7084.5	-16944.0
RPL27	-1532.5	-406.0
RPL27A	-1524.5	1726.0
RPL28	3929.5	3194.0
RPL29	-2277.5	-3035.0
RPL3	-4092.5	-11340.0
RPL30	-528.5	-248.0
RPL31	-13148.5	-13322.0
RPL32	2638.5	2750.0
RPL34	3994.5	3529.0
RPL35	1466.5	2921.0
RPL35A	4081.5	3721.0
RPL36	-2623.5	-2663.0
RPL36AL	-5460.5	-4233.0
RPL37	-3994.5	-3984.0
RPL37A	-4154.5	-2715.0
RPL38	-15057.5	-18437.0
RPL39L	2140.5	1353.0
RPL3L	-11023.5	-3306.0
RPL4	3769.5	3490.0
RPL41	4003.5	3262.0
RPL5	-2029.5	-7354.0
RPL6	-8585.5	-18755.0
RPL7	-2241.5	1376.0
RPL7A	-2123.5	-1243.0
RPL8	-1223.5	-1317.0
RPL9	-1192.5	-3922.0
RPLP0	-2082.5	255.0
RPLP1	-10891.5	-17514.0
RPLP2	-1960.5	1779.0
RPS10	-3622.5	-8002.0
RPS11	1998.5	2177.0
RPS12	4442.5	3999.0
RPS13	2859.5	-3324.0
RPS14	-3250.5	-11554.0
RPS15	-5736.5	-13164.0
RPS15A	-5843.5	-3391.0
RPS16	-2274.5	1705.0
RPS17	0.5	594.0
RPS18	2312.5	1041.0
RPS19	3500.5	3394.0
RPS2	-2384.5	-1176.0
RPS20	-2002.5	-1705.0
RPS21	1289.5	1172.0
RPS23	1573.5	1255.0
RPS24	-7343.5	-12237.0
RPS25	2765.5	-5634.0
RPS26	-7549.5	-10733.0
RPS27	795.5	1318.0
RPS27A	3945.5	3331.0
RPS27L	1726.5	1431.0
RPS28	-12309.5	-20224.0
RPS29	2499.5	1625.0
RPS3	-2501.5	-968.0
RPS3A	-1000.5	-746.0
RPS5	2320.5	-19598.0
RPS6	-8194.5	-8979.0
RPS7	-6542.5	-9140.0
RPS8	-5881.5	-5504.0
RPS9	-9374.5	-19042.0
RPSA	1312.5	644.0
SECISBP2	-15063.5	-14557.0
SEPHS2	-3604.5	-2789.0
SEPSECS	-683.5	-5351.0
UBA52	-3287.5	-1797.0

---

---

Fatty acids

Fatty acids

metric	value
setSize	15
pMANOVA	0.00884
p.adjustMANOVA	0.0432
s.dist	0.557
s.t	0.454
s.fry	0.323
p.t	0.00233
p.fry	0.0304

Top 20 genes

Gene	t	fry
CYP4A11	3492.5	3218
CYP4A22	3119.5	2309
CYP4F2	3048.5	2274
CYP4F8	2468.5	1177

Click HERE to show all gene set members

All member genes

	t	fry
CYP2A13	-9497.5	-19553
CYP2A7	-7529.5	-8868
CYP2B6	-4186.5	-15781
CYP2D6	-18597.5	-14342
CYP2F1	1557.5	-1101
CYP2J2	-13296.5	-11833
CYP4A11	3492.5	3218
CYP4A22	3119.5	2309
CYP4B1	1486.5	-3641
CYP4F11	-1368.5	218
CYP4F12	-1486.5	-533
CYP4F2	3048.5	2274
CYP4F22	2162.5	-2229
CYP4F3	508.5	-227
CYP4F8	2468.5	1177

---

---

MET activates RAS signaling

MET activates RAS signaling

metric	value
setSize	11
pMANOVA	0.04
p.adjustMANOVA	0.136
s.dist	0.555
s.t	-0.441
s.fry	-0.338
p.t	0.0113
p.fry	0.0526

Top 20 genes

Gene	t	fry
MET	-20519.5	-20056
HGF	-19420.5	-13401
SOS1	-18542.5	-13991
RANBP9	-16810.5	-13743
KRAS	-11842.5	-16612
HRAS	-15820.5	-12286
MUC20	-13641.5	-13955
RANBP10	-10835.5	-13420
GRB2	-11200.5	-12557
SHC1	-9611.5	-6269
NRAS	-6371.5	-7675

Click HERE to show all gene set members

All member genes

	t	fry
GRB2	-11200.5	-12557
HGF	-19420.5	-13401
HRAS	-15820.5	-12286
KRAS	-11842.5	-16612
MET	-20519.5	-20056
MUC20	-13641.5	-13955
NRAS	-6371.5	-7675
RANBP10	-10835.5	-13420
RANBP9	-16810.5	-13743
SHC1	-9611.5	-6269
SOS1	-18542.5	-13991

---

---

Free fatty acids regulate insulin secretion

Free fatty acids regulate insulin secretion

metric	value
setSize	10
pMANOVA	0.017
p.adjustMANOVA	0.0723
s.dist	0.552
s.t	-0.483
s.fry	-0.267
p.t	0.00813
p.fry	0.144

Top 20 genes

Gene	t	fry
GNAQ	-21106.5	-20753
PLCB1	-20686.5	-17098
GNA15	-21016.5	-13842
ACSL3	-19234.5	-14973
CD36	-16654.5	-14228
PLCB2	-13764.5	-11830
GNA11	-14475.5	-9697
PLCB3	-9882.5	-9101
GNA14	-5763.5	-11688

Click HERE to show all gene set members

All member genes

	t	fry
ACSL3	-19234.5	-14973
CD36	-16654.5	-14228
FFAR1	-3394.5	1390
GNA11	-14475.5	-9697
GNA14	-5763.5	-11688
GNA15	-21016.5	-13842
GNAQ	-21106.5	-20753
PLCB1	-20686.5	-17098
PLCB2	-13764.5	-11830
PLCB3	-9882.5	-9101

---

---

Viral mRNA Translation

Viral mRNA Translation

metric	value
setSize	84
pMANOVA	8.38e-11
p.adjustMANOVA	4.63e-09
s.dist	0.552
s.t	0.43
s.fry	0.346
p.t	9.65e-12
p.fry	4.18e-08

Top 20 genes

Gene	t	fry
RPS12	4442.5	3999
RPL35A	4081.5	3721
RPL34	3994.5	3529
RPL4	3769.5	3490
RPS27A	3945.5	3331
RPL41	4003.5	3262
RPL28	3929.5	3194
RPS19	3500.5	3394
RPL23	2913.5	3066
RPL32	2638.5	2750
RPS11	1998.5	2177
RPL35	1466.5	2921
RPS29	2499.5	1625
RPL39L	2140.5	1353
RPS27L	1726.5	1431
RPS18	2312.5	1041
RPS23	1573.5	1255
RPS21	1289.5	1172
RPS27	795.5	1318
RPSA	1312.5	644

Click HERE to show all gene set members

All member genes

	t	fry
DNAJC3	-18772.5	-14283.0
FAU	1029.5	358.0
GRSF1	-17241.5	-20443.0
RPL10A	-2906.5	-3724.0
RPL10L	-16334.5	-11519.0
RPL11	-8109.5	-16403.0
RPL12	-2240.5	-714.0
RPL13	571.5	-223.0
RPL13A	-7169.0	-6194.5
RPL14	-2303.5	2151.0
RPL15	-868.5	261.0
RPL17	1840.5	-4757.0
RPL18	-586.5	499.0
RPL18A	-979.5	-494.0
RPL19	-7251.5	-11176.0
RPL21	-4831.5	-9326.0
RPL22	-5310.5	-7738.0
RPL22L1	-11556.5	-12495.0
RPL23	2913.5	3066.0
RPL23A	626.5	-1277.0
RPL24	-5578.5	-8548.0
RPL26	-1432.5	-4386.0
RPL26L1	-7084.5	-16944.0
RPL27	-1532.5	-406.0
RPL27A	-1524.5	1726.0
RPL28	3929.5	3194.0
RPL29	-2277.5	-3035.0
RPL3	-4092.5	-11340.0
RPL30	-528.5	-248.0
RPL31	-13148.5	-13322.0
RPL32	2638.5	2750.0
RPL34	3994.5	3529.0
RPL35	1466.5	2921.0
RPL35A	4081.5	3721.0
RPL36	-2623.5	-2663.0
RPL36AL	-5460.5	-4233.0
RPL37	-3994.5	-3984.0
RPL37A	-4154.5	-2715.0
RPL38	-15057.5	-18437.0
RPL39L	2140.5	1353.0
RPL3L	-11023.5	-3306.0
RPL4	3769.5	3490.0
RPL41	4003.5	3262.0
RPL5	-2029.5	-7354.0
RPL6	-8585.5	-18755.0
RPL7	-2241.5	1376.0
RPL7A	-2123.5	-1243.0
RPL8	-1223.5	-1317.0
RPL9	-1192.5	-3922.0
RPLP0	-2082.5	255.0
RPLP1	-10891.5	-17514.0
RPLP2	-1960.5	1779.0
RPS10	-3622.5	-8002.0
RPS11	1998.5	2177.0
RPS12	4442.5	3999.0
RPS13	2859.5	-3324.0
RPS14	-3250.5	-11554.0
RPS15	-5736.5	-13164.0
RPS15A	-5843.5	-3391.0
RPS16	-2274.5	1705.0
RPS17	0.5	594.0
RPS18	2312.5	1041.0
RPS19	3500.5	3394.0
RPS2	-2384.5	-1176.0
RPS20	-2002.5	-1705.0
RPS21	1289.5	1172.0
RPS23	1573.5	1255.0
RPS24	-7343.5	-12237.0
RPS25	2765.5	-5634.0
RPS26	-7549.5	-10733.0
RPS27	795.5	1318.0
RPS27A	3945.5	3331.0
RPS27L	1726.5	1431.0
RPS28	-12309.5	-20224.0
RPS29	2499.5	1625.0
RPS3	-2501.5	-968.0
RPS3A	-1000.5	-746.0
RPS5	2320.5	-19598.0
RPS6	-8194.5	-8979.0
RPS7	-6542.5	-9140.0
RPS8	-5881.5	-5504.0
RPS9	-9374.5	-19042.0
RPSA	1312.5	644.0
UBA52	-3287.5	-1797.0

---

---

RHOU GTPase cycle

RHOU GTPase cycle

metric	value
setSize	37
pMANOVA	2.57e-05
p.adjustMANOVA	0.000394
s.dist	0.551
s.t	-0.436
s.fry	-0.337
p.t	4.35e-06
p.fry	0.000386

Top 20 genes

Gene	t	fry
DST	-21040.5	-20248.0
ITSN2	-20785.5	-19434.0
CLTC	-18899.5	-19383.0
PAK2	-20027.5	-17613.0
SPTBN1	-20623.5	-16664.0
MYO6	-18324.5	-18514.0
GIT2	-18018.5	-18205.0
IQGAP1	-18048.5	-17000.0
PTK2B	-20408.5	-14458.0
DLG5	-18923.5	-15574.0
NCK1	-16385.5	-17538.0
STAM2	-15047.5	-18966.0
EPHA2	-20591.5	-12867.0
PEAK1	-18246.5	-14224.0
NCK2	-19331.5	-13243.0
PARD6A	-14240.0	-17758.5
VANGL1	-13055.5	-19261.0
SRGAP2	-16549.5	-13041.0
ARHGEF7	-18171.5	-11837.0
ARHGAP31	-11271.5	-18220.0

Click HERE to show all gene set members

All member genes

	t	fry
ARHGAP30	2948.5	2932.0
ARHGAP31	-11271.5	-18220.0
ARHGEF7	-18171.5	-11837.0
CDC42	-4538.5	-13348.0
CLTC	-18899.5	-19383.0
DEPDC1B	-3101.5	-3475.0
DLG5	-18923.5	-15574.0
DST	-21040.5	-20248.0
EPHA2	-20591.5	-12867.0
GIT1	-12303.5	-6713.0
GIT2	-18018.5	-18205.0
GRB2	-11200.5	-12557.0
HGS	-8349.5	-6400.0
IQGAP1	-18048.5	-17000.0
ITSN2	-20785.5	-19434.0
MYO6	-18324.5	-18514.0
NCK1	-16385.5	-17538.0
NCK2	-19331.5	-13243.0
PAK1	-16158.5	-11852.0
PAK2	-20027.5	-17613.0
PAK4	-11411.5	-8352.0
PARD6A	-14240.0	-17758.5
PEAK1	-18246.5	-14224.0
PIK3R1	-9935.5	-17042.0
PIK3R2	-12609.5	-7716.0
PTK2B	-20408.5	-14458.0
RHOU	-9805.5	-19683.0
SPTAN1	-5825.5	-14432.0
SPTBN1	-20623.5	-16664.0
SRC	-17084.5	-8079.0
SRGAP2	-16549.5	-13041.0
STAM	-17681.5	-11427.0
STAM2	-15047.5	-18966.0
TXNL1	-736.5	-588.0
VANGL1	-13055.5	-19261.0
WDR6	-1479.5	-1757.0
WWP2	-20252.5	-9351.0

---

---

RHOV GTPase cycle

RHOV GTPase cycle

metric	value
setSize	36
pMANOVA	9.56e-05
p.adjustMANOVA	0.00103
s.dist	0.551
s.t	-0.407
s.fry	-0.371
p.t	2.39e-05
p.fry	0.000114

Top 20 genes

Gene	t	fry
WASL	-20929.5	-21466.0
DST	-21040.5	-20248.0
MYO9A	-21174.5	-18795.0
SH3RF1	-21072.5	-17507.0
CLTC	-18899.5	-19383.0
PAK2	-20027.5	-17613.0
SPTBN1	-20623.5	-16664.0
GIT2	-18018.5	-18205.0
IQGAP1	-18048.5	-17000.0
ARHGAP12	-17181.5	-17782.0
DLG5	-18923.5	-15574.0
NCK1	-16385.5	-17538.0
EPHA2	-20591.5	-12867.0
PEAK1	-18246.5	-14224.0
PARD6B	-13466.5	-19267.0
NCK2	-19331.5	-13243.0
PARD6A	-14240.0	-17758.5
VANGL1	-13055.5	-19261.0
TPM3	-14450.5	-15137.0
ARHGEF7	-18171.5	-11837.0

Click HERE to show all gene set members

All member genes

	t	fry
ARHGAP12	-17181.5	-17782.0
ARHGEF7	-18171.5	-11837.0
CCP110	-8981.5	-6661.0
CDC42	-4538.5	-13348.0
CEP97	2811.5	-6521.0
CLTC	-18899.5	-19383.0
DEPDC1B	-3101.5	-3475.0
DLG5	-18923.5	-15574.0
DST	-21040.5	-20248.0
EPHA2	-20591.5	-12867.0
GIT1	-12303.5	-6713.0
GIT2	-18018.5	-18205.0
IQGAP1	-18048.5	-17000.0
MAP3K11	-10292.5	-4107.0
MYO9A	-21174.5	-18795.0
NCK1	-16385.5	-17538.0
NCK2	-19331.5	-13243.0
PAK1	-16158.5	-11852.0
PAK2	-20027.5	-17613.0
PAK4	-11411.5	-8352.0
PAK6	-13168.5	-16106.0
PARD6A	-14240.0	-17758.5
PARD6B	-13466.5	-19267.0
PEAK1	-18246.5	-14224.0
PIK3R1	-9935.5	-17042.0
RHOV	-6457.5	-13250.0
SH3RF1	-21072.5	-17507.0
SPTAN1	-5825.5	-14432.0
SPTBN1	-20623.5	-16664.0
TPM3	-14450.5	-15137.0
TPM4	-12318.5	-15765.0
TXNL1	-736.5	-588.0
VANGL1	-13055.5	-19261.0
WASL	-20929.5	-21466.0
WDR6	-1479.5	-1757.0
ZNF512B	-12098.5	-5359.0

---

---

TICAM1-dependent activation of IRF3/IRF7

TICAM1-dependent activation of IRF3/IRF7

metric	value
setSize	12
pMANOVA	0.0494
p.adjustMANOVA	0.156
s.dist	0.547
s.t	0.377
s.fry	0.396
p.t	0.0235
p.fry	0.0176

Top 20 genes

Gene	t	fry
TLR3	4049.5	3914
UBB	4311.5	3147
RPS27A	3945.5	3331

Click HERE to show all gene set members

All member genes

	t	fry
IKBKE	-2627.5	-3119
IRF3	-5025.5	-2824
IRF7	-4746.5	-6246
RPS27A	3945.5	3331
TANK	-12847.5	-13003
TBK1	-7854.5	-7947
TICAM1	1247.5	-2172
TLR3	4049.5	3914
TRAF3	-20277.5	-15334
UBA52	-3287.5	-1797
UBB	4311.5	3147
UBC	815.5	-1813

---

---

PRC2 methylates histones and DNA

PRC2 methylates histones and DNA

metric	value
setSize	13
pMANOVA	0.0383
p.adjustMANOVA	0.132
s.dist	0.539
s.t	-0.355
s.fry	-0.406
p.t	0.0265
p.fry	0.0113

Top 20 genes

Gene	t	fry
EZH2	-18887.5	-21368
DNMT3B	-19992.5	-18681
SUZ12	-19169.5	-17327
DNMT3A	-20312.5	-15933
AEBP2	-19018.5	-16065
JARID2	-21169.5	-13429
MTF2	-10111.5	-20872
DNMT1	-15205.5	-12883
PHF1	-10522.5	-17447
EED	-4889.5	-14275
H2AFX	-7443.5	-4428
PHF19	-1077.5	-8994

Click HERE to show all gene set members

All member genes

	t	fry
AEBP2	-19018.5	-16065
DNMT1	-15205.5	-12883
DNMT3A	-20312.5	-15933
DNMT3B	-19992.5	-18681
EED	-4889.5	-14275
EZH2	-18887.5	-21368
H2AFX	-7443.5	-4428
JARID2	-21169.5	-13429
MTF2	-10111.5	-20872
PHF1	-10522.5	-17447
PHF19	-1077.5	-8994
RBBP4	-578.5	186
SUZ12	-19169.5	-17327

---

---

TICAM1,TRAF6-dependent induction of TAK1 complex

TICAM1,TRAF6-dependent induction of TAK1 complex

metric	value
setSize	10
pMANOVA	0.0852
p.adjustMANOVA	0.229
s.dist	0.538
s.t	0.36
s.fry	0.399
p.t	0.0484
p.fry	0.0288

Top 20 genes

Gene	t	fry
TLR3	4049.5	3914
UBB	4311.5	3147
RPS27A	3945.5	3331

Click HERE to show all gene set members

All member genes

	t	fry
MAP3K7	-9314.5	-15338
RPS27A	3945.5	3331
TAB1	-12099.5	-6676
TAB2	-14674.5	-8217
TICAM1	1247.5	-2172
TLR3	4049.5	3914
TRAF6	-12428.5	-10486
UBA52	-3287.5	-1797
UBB	4311.5	3147
UBC	815.5	-1813

---

---

Laminin interactions

Laminin interactions

metric	value
setSize	23
pMANOVA	7.51e-05
p.adjustMANOVA	0.000841
s.dist	0.537
s.t	-0.477
s.fry	-0.247
p.t	7.52e-05
p.fry	0.04

Top 20 genes

Gene	t	fry
LAMA2	-21075.5	-19859
LAMA1	-19671.5	-21161
ITGA2	-19036.5	-21139
ITGA6	-19963.5	-19551
LAMB1	-17906.5	-19710
ITGA1	-20587.5	-16039
LAMA4	-20680.5	-15139
LAMC1	-16806.5	-18020
NID2	-15437.5	-19411
NID1	-15502.5	-15699
ITGB4	-18269.5	-12370
ITGAV	-14469.5	-12437
ITGB1	-14247.5	-9885
LAMB2	-16883.5	-7157
LAMC3	-11636.5	-8837
COL18A1	-16292.5	-5938
LAMC2	-11001.5	-7945
LAMA5	-14590.5	-5816
LAMB3	-11202.5	-7089
ITGA7	-9185.5	-8082

Click HERE to show all gene set members

All member genes

	t	fry
COL18A1	-16292.5	-5938
HSPG2	-9566.5	-3774
ITGA1	-20587.5	-16039
ITGA2	-19036.5	-21139
ITGA3	1516.5	1219
ITGA6	-19963.5	-19551
ITGA7	-9185.5	-8082
ITGAV	-14469.5	-12437
ITGB1	-14247.5	-9885
ITGB4	-18269.5	-12370
LAMA1	-19671.5	-21161
LAMA2	-21075.5	-19859
LAMA3	-1258.5	-460
LAMA4	-20680.5	-15139
LAMA5	-14590.5	-5816
LAMB1	-17906.5	-19710
LAMB2	-16883.5	-7157
LAMB3	-11202.5	-7089
LAMC1	-16806.5	-18020
LAMC2	-11001.5	-7945
LAMC3	-11636.5	-8837
NID1	-15502.5	-15699
NID2	-15437.5	-19411

---

---

Acetylcholine regulates insulin secretion

Acetylcholine regulates insulin secretion

metric	value
setSize	10
pMANOVA	0.0581
p.adjustMANOVA	0.176
s.dist	0.536
s.t	-0.433
s.fry	-0.316
p.t	0.0177
p.fry	0.0837

Top 20 genes

Gene	t	fry
GNAQ	-21106.5	-20753
PLCB1	-20686.5	-17098
PRKCA	-20671.5	-16608
CHRM3	-15920.5	-20815
GNA15	-21016.5	-13842
PLCB2	-13764.5	-11830
GNA11	-14475.5	-9697
PLCB3	-9882.5	-9101
GNA14	-5763.5	-11688

Click HERE to show all gene set members

All member genes

	t	fry
CHRM3	-15920.5	-20815
GNA11	-14475.5	-9697
GNA14	-5763.5	-11688
GNA15	-21016.5	-13842
GNAQ	-21106.5	-20753
MARCKS	3782.5	3334
PLCB1	-20686.5	-17098
PLCB2	-13764.5	-11830
PLCB3	-9882.5	-9101
PRKCA	-20671.5	-16608

---

---

Termination of O-glycan biosynthesis

Termination of O-glycan biosynthesis

metric	value
setSize	25
pMANOVA	0.00046
p.adjustMANOVA	0.00384
s.dist	0.534
s.t	-0.443
s.fry	-0.297
p.t	0.000124
p.fry	0.01

Top 20 genes

Gene	t	fry
MUC7	-19376.5	-19187
ST6GALNAC3	-19909.5	-16867
ST3GAL2	-20038.5	-15551
ST3GAL1	-16356.5	-17240
ST3GAL3	-19503.5	-13637
MUC5B	-20443.5	-12806
ST6GALNAC2	-16305.5	-15554
MUC15	-11588.5	-20295
MUC2	-19719.5	-11144
MUC13	-15146.5	-14292
ST3GAL4	-19437.5	-11121
MUC20	-13641.5	-13955
MUC19	-9623.5	-18540
MUC12	-11775.5	-14769
MUC21	-14215.5	-10753
MUCL1	-11191.5	-12526
ST6GAL1	-11739.5	-11599
MUC4	-14935.5	-8119
MUC5AC	-16169.5	-7297
MUC1	-9743.5	-11654

Click HERE to show all gene set members

All member genes

	t	fry
MUC1	-9743.5	-11654
MUC12	-11775.5	-14769
MUC13	-15146.5	-14292
MUC15	-11588.5	-20295
MUC16	-9763.5	-8963
MUC17	-4847.5	-2300
MUC19	-9623.5	-18540
MUC2	-19719.5	-11144
MUC20	-13641.5	-13955
MUC21	-14215.5	-10753
MUC3A	-9826.5	-9000
MUC4	-14935.5	-8119
MUC5AC	-16169.5	-7297
MUC5B	-20443.5	-12806
MUC6	-11055.5	-3512
MUC7	-19376.5	-19187
MUCL1	-11191.5	-12526
ST3GAL1	-16356.5	-17240
ST3GAL2	-20038.5	-15551
ST3GAL3	-19503.5	-13637
ST3GAL4	-19437.5	-11121
ST6GAL1	-11739.5	-11599
ST6GALNAC2	-16305.5	-15554
ST6GALNAC3	-19909.5	-16867
ST6GALNAC4	-5664.5	-13582

---

---

MET activates RAP1 and RAC1

MET activates RAP1 and RAC1

metric	value
setSize	11
pMANOVA	0.0736
p.adjustMANOVA	0.209
s.dist	0.53
s.t	-0.389
s.fry	-0.36
p.t	0.0255
p.fry	0.0386

Top 20 genes

Gene	t	fry
MET	-20519.5	-20056
GAB1	-20518.5	-19636
RAC1	-19561.5	-19996
DOCK7	-21122.5	-17799
HGF	-19420.5	-13401
RAP1B	-10498.5	-20182
CRK	-15466.5	-11600
GRB2	-11200.5	-12557
RAPGEF1	-6962.5	-6414
CRKL	-3300.5	-4045

Click HERE to show all gene set members

All member genes

	t	fry
CRK	-15466.5	-11600
CRKL	-3300.5	-4045
DOCK7	-21122.5	-17799
GAB1	-20518.5	-19636
GRB2	-11200.5	-12557
HGF	-19420.5	-13401
MET	-20519.5	-20056
RAC1	-19561.5	-19996
RAP1A	1350.5	-1483
RAP1B	-10498.5	-20182
RAPGEF1	-6962.5	-6414

---

---

Autodegradation of the E3 ubiquitin ligase COP1

Autodegradation of the E3 ubiquitin ligase COP1

metric	value
setSize	50
pMANOVA	9.13e-06
p.adjustMANOVA	0.00019
s.dist	0.528
s.t	0.374
s.fry	0.372
p.t	4.62e-06
p.fry	5.36e-06

Top 20 genes

Gene	t	fry
UBB	4311.5	3147
RPS27A	3945.5	3331
PSMC2	3633.5	3282
PSMA5	3622.5	3082
ATM	3525.5	3131
PSMC4	3518.5	2489
PSME3	2784.5	2900
PSMD7	3174.5	2061
PSMA2	1921.5	2430
PSMB9	1700.5	1230
PSMD3	1886.5	964
PSMB11	1982.5	636
PSMD12	678.5	1670
PSME1	1438.5	773
PSMB1	713.5	392

Click HERE to show all gene set members

All member genes

	t	fry
ATM	3525.5	3131
PSMA1	-7249.5	-8787
PSMA2	1921.5	2430
PSMA3	-883.5	1117
PSMA4	-1248.5	-912
PSMA5	3622.5	3082
PSMA6	-3523.5	-2798
PSMA7	-4607.5	-4364
PSMA8	-4253.5	-2545
PSMB1	713.5	392
PSMB10	-9447.5	-8607
PSMB11	1982.5	636
PSMB2	-4046.5	-2961
PSMB3	-2368.5	-1867
PSMB4	-1938.5	-6925
PSMB5	-5107.5	-8535
PSMB6	-5511.5	-14238
PSMB7	-7935.5	-3197
PSMB8	-1609.5	-1641
PSMB9	1700.5	1230
PSMC1	-995.5	-520
PSMC2	3633.5	3282
PSMC3	-5003.5	-3621
PSMC4	3518.5	2489
PSMC5	-5616.5	-8155
PSMC6	-9203.5	-11150
PSMD1	-21024.5	-14763
PSMD11	-2579.5	-955
PSMD12	678.5	1670
PSMD13	-4590.5	-4837
PSMD14	-19831.5	-20698
PSMD2	-5162.5	-5850
PSMD3	1886.5	964
PSMD4	2425.5	-1895
PSMD5	-531.5	-236
PSMD6	-19512.5	-16261
PSMD7	3174.5	2061
PSMD8	-12774.5	-21155
PSMD9	-7505.5	-4424
PSME1	1438.5	773
PSME2	-500.5	105
PSME3	2784.5	2900
PSME4	-14980.5	-16231
PSMF1	-8946.5	-7306
RFWD2	-14404.5	-17847
RPS27A	3945.5	3331
TP53	-4491.5	-4353
UBA52	-3287.5	-1797
UBB	4311.5	3147
UBC	815.5	-1813

---

---

Assembly of the ORC complex at the origin of replication

Assembly of the ORC complex at the origin of replication

metric	value
setSize	10
pMANOVA	0.0643
p.adjustMANOVA	0.191
s.dist	0.527
s.t	-0.311
s.fry	-0.425
p.t	0.0885
p.fry	0.0199

Top 20 genes

Gene	t	fry
ORC4	-20994.5	-19559
KPNA1	-18532.5	-20914
ORC5	-17161.5	-18405
ORC2	-17398.5	-14773
ORC1	-14176.5	-17870
ORC6	-10792.5	-18999
ORC3	-14152.5	-11067
KPNA6	-6924.5	-18383
H2AFX	-7443.5	-4428

Click HERE to show all gene set members

All member genes

	t	fry
H2AFX	-7443.5	-4428
KPNA1	-18532.5	-20914
KPNA6	-6924.5	-18383
KPNB1	3759.5	2227
ORC1	-14176.5	-17870
ORC2	-17398.5	-14773
ORC3	-14152.5	-11067
ORC4	-20994.5	-19559
ORC5	-17161.5	-18405
ORC6	-10792.5	-18999

---

---

Synthesis of PIPs at the plasma membrane

Synthesis of PIPs at the plasma membrane

metric	value
setSize	48
pMANOVA	1.22e-05
p.adjustMANOVA	0.000235
s.dist	0.526
s.t	-0.391
s.fry	-0.352
p.t	2.73e-06
p.fry	2.45e-05

Top 20 genes

Gene	t	fry
PIK3C2G	-21191.5	-20842
MTMR9	-21017.5	-20336
SBF2	-20965.5	-18002
INPP4B	-20238.5	-18098
PIP5K1B	-17096.5	-21258
PIK3R3	-16778.5	-21545
PIK3C2A	-18391.5	-19576
PLEKHA5	-21212.5	-16639
MTMR3	-20889.5	-16896
PIK3CB	-21217.5	-16074
PIP4K2C	-15398.5	-21543
MTMR2	-15172.5	-21135
RAB14	-14999.5	-19545
PLEKHA1	-20064.5	-14271
PIP5K1C	-20223.5	-13851
PLEKHA8	-14037.5	-19781
INPP4A	-17582.5	-14987
PIK3R6	-17651.5	-14109
SYNJ1	-15421.5	-15678
SYNJ2	-20771.5	-11089

Click HERE to show all gene set members

All member genes

	t	fry
ARF1	-13022.5	-15177
INPP4A	-17582.5	-14987
INPP4B	-20238.5	-18098
INPP5D	-5400.5	-4476
INPP5J	-13516.5	-8619
INPP5K	-6902.5	-7464
INPPL1	-10455.5	-11203
MTMR14	-10142.5	-16275
MTMR2	-15172.5	-21135
MTMR3	-20889.5	-16896
MTMR6	-8292.5	-9447
MTMR9	-21017.5	-20336
PI4K2A	-7908.5	-15965
PI4K2B	-1508.5	-488
PIK3C2A	-18391.5	-19576
PIK3C2B	-18335.5	-11858
PIK3C2G	-21191.5	-20842
PIK3CA	-650.5	279
PIK3CB	-21217.5	-16074
PIK3CD	-7081.5	-5407
PIK3CG	-2685.5	-2649
PIK3R1	-9935.5	-17042
PIK3R2	-12609.5	-7716
PIK3R3	-16778.5	-21545
PIK3R5	-6704.5	-3311
PIK3R6	-17651.5	-14109
PIP4K2A	-13015.5	-12515
PIP4K2B	-12134.5	-18492
PIP4K2C	-15398.5	-21543
PIP5K1A	-10125.5	-15114
PIP5K1B	-17096.5	-21258
PIP5K1C	-20223.5	-13851
PLEKHA1	-20064.5	-14271
PLEKHA2	-13640.5	-8517
PLEKHA3	895.5	-2527
PLEKHA4	-11708.5	-18552
PLEKHA5	-21212.5	-16639
PLEKHA6	-12767.5	-5817
PLEKHA8	-14037.5	-19781
PTEN	-10170.5	-13554
PTPN13	-9337.5	-11569
RAB14	-14999.5	-19545
RAB4A	-17389.5	-12552
RAB5A	-10302.5	-16649
RUFY1	-18257.5	-8870
SBF2	-20965.5	-18002
SYNJ1	-15421.5	-15678
SYNJ2	-20771.5	-11089

---

---

AUF1 (hnRNP D0) binds and destabilizes mRNA

AUF1 (hnRNP D0) binds and destabilizes mRNA

metric	value
setSize	53
pMANOVA	4.87e-06
p.adjustMANOVA	0.000114
s.dist	0.526
s.t	0.366
s.fry	0.377
p.t	4.02e-06
p.fry	1.98e-06

Top 20 genes

Gene	t	fry
UBB	4311.5	3147
RPS27A	3945.5	3331
PSMC2	3633.5	3282
PSMA5	3622.5	3082
PSMC4	3518.5	2489
PSME3	2784.5	2900
HSPA1A	3853.5	1901
PSMD7	3174.5	2061
HNRNPD	3107.5	1770
PSMA2	1921.5	2430
PSMB9	1700.5	1230
PSMD3	1886.5	964
PSMB11	1982.5	636
PSMD12	678.5	1670
PSME1	1438.5	773
PSMB1	713.5	392

Click HERE to show all gene set members

All member genes

	t	fry
EIF4G1	-7345.5	-4999
HNRNPD	3107.5	1770
HSPA1A	3853.5	1901
HSPA8	-3209.5	-2375
HSPB1	-10681.5	-12473
PABPC1	-17586.5	-10991
PSMA1	-7249.5	-8787
PSMA2	1921.5	2430
PSMA3	-883.5	1117
PSMA4	-1248.5	-912
PSMA5	3622.5	3082
PSMA6	-3523.5	-2798
PSMA7	-4607.5	-4364
PSMA8	-4253.5	-2545
PSMB1	713.5	392
PSMB10	-9447.5	-8607
PSMB11	1982.5	636
PSMB2	-4046.5	-2961
PSMB3	-2368.5	-1867
PSMB4	-1938.5	-6925
PSMB5	-5107.5	-8535
PSMB6	-5511.5	-14238
PSMB7	-7935.5	-3197
PSMB8	-1609.5	-1641
PSMB9	1700.5	1230
PSMC1	-995.5	-520
PSMC2	3633.5	3282
PSMC3	-5003.5	-3621
PSMC4	3518.5	2489
PSMC5	-5616.5	-8155
PSMC6	-9203.5	-11150
PSMD1	-21024.5	-14763
PSMD11	-2579.5	-955
PSMD12	678.5	1670
PSMD13	-4590.5	-4837
PSMD14	-19831.5	-20698
PSMD2	-5162.5	-5850
PSMD3	1886.5	964
PSMD4	2425.5	-1895
PSMD5	-531.5	-236
PSMD6	-19512.5	-16261
PSMD7	3174.5	2061
PSMD8	-12774.5	-21155
PSMD9	-7505.5	-4424
PSME1	1438.5	773
PSME2	-500.5	105
PSME3	2784.5	2900
PSME4	-14980.5	-16231
PSMF1	-8946.5	-7306
RPS27A	3945.5	3331
UBA52	-3287.5	-1797
UBB	4311.5	3147
UBC	815.5	-1813

---

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

metric	value
setSize	95
pMANOVA	3.91e-11
p.adjustMANOVA	2.88e-09
s.dist	0.525
s.t	0.411
s.fry	0.327
p.t	4.42e-12
p.fry	3.58e-08

Top 20 genes

Gene	t	fry
RPS12	4442.5	3999
RPL35A	4081.5	3721
EIF2S2	4117.5	3541
RPL34	3994.5	3529
RPL4	3769.5	3490
RPS27A	3945.5	3331
RPL41	4003.5	3262
RPL28	3929.5	3194
RPS19	3500.5	3394
RPL23	2913.5	3066
DDIT3	2885.5	2549
RPL32	2638.5	2750
RPS11	1998.5	2177
RPL35	1466.5	2921
RPS29	2499.5	1625
RPL39L	2140.5	1353
RPS27L	1726.5	1431
RPS18	2312.5	1041
RPS23	1573.5	1255
ATF2	1834.5	1055

Click HERE to show all gene set members

All member genes

	t	fry
ASNS	-1185.5	-3325.0
ATF2	1834.5	1055.0
ATF3	-4724.5	-13680.0
ATF4	1217.5	187.0
CEBPB	-7362.5	-13316.0
CEBPG	-16300.5	-21360.0
DDIT3	2885.5	2549.0
EIF2AK4	-20812.5	-18295.0
EIF2S1	-8139.5	-10547.0
EIF2S2	4117.5	3541.0
FAU	1029.5	358.0
GCN1	-19228.5	-12849.0
IMPACT	-19004.5	-11990.0
RPL10A	-2906.5	-3724.0
RPL10L	-16334.5	-11519.0
RPL11	-8109.5	-16403.0
RPL12	-2240.5	-714.0
RPL13	571.5	-223.0
RPL13A	-7169.0	-6194.5
RPL14	-2303.5	2151.0
RPL15	-868.5	261.0
RPL17	1840.5	-4757.0
RPL18	-586.5	499.0
RPL18A	-979.5	-494.0
RPL19	-7251.5	-11176.0
RPL21	-4831.5	-9326.0
RPL22	-5310.5	-7738.0
RPL22L1	-11556.5	-12495.0
RPL23	2913.5	3066.0
RPL23A	626.5	-1277.0
RPL24	-5578.5	-8548.0
RPL26	-1432.5	-4386.0
RPL26L1	-7084.5	-16944.0
RPL27	-1532.5	-406.0
RPL27A	-1524.5	1726.0
RPL28	3929.5	3194.0
RPL29	-2277.5	-3035.0
RPL3	-4092.5	-11340.0
RPL30	-528.5	-248.0
RPL31	-13148.5	-13322.0
RPL32	2638.5	2750.0
RPL34	3994.5	3529.0
RPL35	1466.5	2921.0
RPL35A	4081.5	3721.0
RPL36	-2623.5	-2663.0
RPL36AL	-5460.5	-4233.0
RPL37	-3994.5	-3984.0
RPL37A	-4154.5	-2715.0
RPL38	-15057.5	-18437.0
RPL39L	2140.5	1353.0
RPL3L	-11023.5	-3306.0
RPL4	3769.5	3490.0
RPL41	4003.5	3262.0
RPL5	-2029.5	-7354.0
RPL6	-8585.5	-18755.0
RPL7	-2241.5	1376.0
RPL7A	-2123.5	-1243.0
RPL8	-1223.5	-1317.0
RPL9	-1192.5	-3922.0
RPLP0	-2082.5	255.0
RPLP1	-10891.5	-17514.0
RPLP2	-1960.5	1779.0
RPS10	-3622.5	-8002.0
RPS11	1998.5	2177.0
RPS12	4442.5	3999.0
RPS13	2859.5	-3324.0
RPS14	-3250.5	-11554.0
RPS15	-5736.5	-13164.0
RPS15A	-5843.5	-3391.0
RPS16	-2274.5	1705.0
RPS17	0.5	594.0
RPS18	2312.5	1041.0
RPS19	3500.5	3394.0
RPS2	-2384.5	-1176.0
RPS20	-2002.5	-1705.0
RPS21	1289.5	1172.0
RPS23	1573.5	1255.0
RPS24	-7343.5	-12237.0
RPS25	2765.5	-5634.0
RPS26	-7549.5	-10733.0
RPS27	795.5	1318.0
RPS27A	3945.5	3331.0
RPS27L	1726.5	1431.0
RPS28	-12309.5	-20224.0
RPS29	2499.5	1625.0
RPS3	-2501.5	-968.0
RPS3A	-1000.5	-746.0
RPS5	2320.5	-19598.0
RPS6	-8194.5	-8979.0
RPS7	-6542.5	-9140.0
RPS8	-5881.5	-5504.0
RPS9	-9374.5	-19042.0
RPSA	1312.5	644.0
TRIB3	-4166.5	-7350.0
UBA52	-3287.5	-1797.0

---

---

Regulation of RUNX1 Expression and Activity

Regulation of RUNX1 Expression and Activity

metric	value
setSize	25
pMANOVA	0.000301
p.adjustMANOVA	0.00272
s.dist	0.524
s.t	-0.446
s.fry	-0.275
p.t	0.000113
p.fry	0.0172

Top 20 genes

Gene	t	fry
AGO4	-19034.5	-16955.0
CDK6	-18288.5	-17056.0
TNRC6A	-20383.5	-15256.0
CBFB	-17357.5	-16642.0
AGO1	-18198.5	-15518.0
MIR215	-19923.0	-13644.5
CCND1	-15240.5	-15679.0
PML	-18913.5	-12536.0
TNRC6C	-20034.5	-11485.0
MIR18A	-10984.5	-19063.0
RUNX1	-17747.5	-11499.0
MIR302B	-19774.5	-10176.0
MIR20A	-10173.5	-17165.0
CCND2	-9259.5	-18140.0
MOV10	-10270.5	-15127.0
SRC	-17084.5	-8079.0
H19	-19159.5	-6312.0
AGO3	-11519.5	-9216.0
MIR675	-13329.5	-6472.0
PTPN11	-6749.5	-12640.0

Click HERE to show all gene set members

All member genes

	t	fry
AGO1	-18198.5	-15518.0
AGO2	-8596.5	-4508.0
AGO3	-11519.5	-9216.0
AGO4	-19034.5	-16955.0
CBFB	-17357.5	-16642.0
CCND1	-15240.5	-15679.0
CCND2	-9259.5	-18140.0
CCND3	-5534.5	-10526.0
CDK6	-18288.5	-17056.0
H19	-19159.5	-6312.0
MIR17	-6310.5	-10650.0
MIR18A	-10984.5	-19063.0
MIR20A	-10173.5	-17165.0
MIR215	-19923.0	-13644.5
MIR27A	-10296.5	-5717.0
MIR302B	-19774.5	-10176.0
MIR675	-13329.5	-6472.0
MOV10	-10270.5	-15127.0
PML	-18913.5	-12536.0
PTPN11	-6749.5	-12640.0
RUNX1	-17747.5	-11499.0
SRC	-17084.5	-8079.0
TNRC6A	-20383.5	-15256.0
TNRC6B	-8673.5	-7031.0
TNRC6C	-20034.5	-11485.0

---

---

MECP2 regulates neuronal receptors and channels

MECP2 regulates neuronal receptors and channels

metric	value
setSize	17
pMANOVA	0.0209
p.adjustMANOVA	0.0847
s.dist	0.521
s.t	-0.375
s.fry	-0.362
p.t	0.00735
p.fry	0.00979

Top 20 genes

Gene	t	fry
MET	-20519.5	-20056
OPRK1	-18489.5	-19273
CREB1	-19308.5	-17097
PTPN1	-15467.5	-20821
PTPN4	-21009.5	-15004
FKBP5	-20000.5	-15353
GRIN2B	-16441.5	-16902
HDAC1	-17692.5	-15702
TRPC3	-14273.5	-17373
OPRM1	-15399.5	-14248
HDAC2	-8685.5	-19720
NOTCH1	-17206.5	-7025
GPRIN1	-6222.5	-16860
GRIA2	-9123.5	-9753
SLC2A3	-3806.5	-1590
GRIN2A	-1752.5	-2977

Click HERE to show all gene set members

All member genes

	t	fry
CREB1	-19308.5	-17097
FKBP5	-20000.5	-15353
GPRIN1	-6222.5	-16860
GRIA2	-9123.5	-9753
GRIN2A	-1752.5	-2977
GRIN2B	-16441.5	-16902
HDAC1	-17692.5	-15702
HDAC2	-8685.5	-19720
MET	-20519.5	-20056
NOTCH1	-17206.5	-7025
OPRK1	-18489.5	-19273
OPRM1	-15399.5	-14248
PTPN1	-15467.5	-20821
PTPN4	-21009.5	-15004
SIN3A	838.5	1963
SLC2A3	-3806.5	-1590
TRPC3	-14273.5	-17373

---

---

Sensory perception of sweet, bitter, and umami (glutamate) taste

Sensory perception of sweet, bitter, and umami (glutamate) taste

metric	value
setSize	41
pMANOVA	3.78e-05
p.adjustMANOVA	0.000512
s.dist	0.52
s.t	-0.407
s.fry	-0.324
p.t	6.39e-06
p.fry	0.000333

Top 20 genes

Gene	t	fry
TAS2R1	-19113.5	-21124
TAS2R20	-20351.5	-19407
TAS2R3	-20396.5	-18194
SCN9A	-17825.5	-20426
TAS2R39	-17173.5	-20346
GRM1	-19257.5	-17483
GNB1	-19965.5	-16002
GNAT3	-21158.5	-14821
TAS2R7	-19603.5	-15407
TAS2R50	-20040.5	-15059
TAS2R14	-19526.5	-15152
TAS2R8	-20364.5	-13744
TAS2R40	-13787.5	-19931
TAS2R10	-19352.5	-14114
TAS2R16	-12702.5	-20738
SCN1B	-15269.5	-17136
TAS2R30	-16154.5	-15164
TAS2R41	-13908.5	-15969
TAS2R46	-17690.5	-11896
GNG13	-9704.5	-19045

Click HERE to show all gene set members

All member genes

	t	fry
CALHM1	-14226.5	-5308
CALHM3	-9496.5	-9781
GNAT3	-21158.5	-14821
GNB1	-19965.5	-16002
GNB3	-11882.5	-6559
GNG13	-9704.5	-19045
GRM1	-19257.5	-17483
GRM4	-13027.5	-2818
ITPR3	-16003.5	-11243
PLCB2	-13764.5	-11830
SCN1B	-15269.5	-17136
SCN2A	-8350.5	-17974
SCN2B	-11584.5	-8754
SCN3A	-6986.5	-17386
SCN4B	-11649.5	-14919
SCN9A	-17825.5	-20426
TAS1R1	-6254.5	-5541
TAS1R2	-3280.5	-1362
TAS1R3	-9439.5	-4078
TAS2R1	-19113.5	-21124
TAS2R10	-19352.5	-14114
TAS2R13	-9328.5	-12880
TAS2R14	-19526.5	-15152
TAS2R16	-12702.5	-20738
TAS2R20	-20351.5	-19407
TAS2R3	-20396.5	-18194
TAS2R30	-16154.5	-15164
TAS2R31	-13874.5	-10175
TAS2R38	-6937.5	-13724
TAS2R39	-17173.5	-20346
TAS2R4	-8536.5	-6913
TAS2R40	-13787.5	-19931
TAS2R41	-13908.5	-15969
TAS2R43	0.5	-11882
TAS2R46	-17690.5	-11896
TAS2R5	-14284.5	-8957
TAS2R50	-20040.5	-15059
TAS2R7	-19603.5	-15407
TAS2R8	-20364.5	-13744
TRPM4	-9862.5	-3605
TRPM5	-5990.5	-2314

---

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

metric	value
setSize	94
pMANOVA	4.21e-11
p.adjustMANOVA	2.88e-09
s.dist	0.52
s.t	0.412
s.fry	0.317
p.t	4.98e-12
p.fry	1.03e-07

Top 20 genes

Gene	t	fry
RPS12	4442.5	3999
RPL35A	4081.5	3721
RPL34	3994.5	3529
RPL4	3769.5	3490
RPS27A	3945.5	3331
RPL41	4003.5	3262
RPL28	3929.5	3194
RPS19	3500.5	3394
RPL23	2913.5	3066
EIF3K	3626.5	2149
RPL32	2638.5	2750
RPS11	1998.5	2177
RPL35	1466.5	2921
RPS29	2499.5	1625
RPL39L	2140.5	1353
RPS27L	1726.5	1431
RPS18	2312.5	1041
RPS23	1573.5	1255
RPS21	1289.5	1172
EIF3D	780.5	1882

Click HERE to show all gene set members

All member genes

	t	fry
EIF3A	-13203.5	-11320.0
EIF3B	-4973.5	-2350.0
EIF3D	780.5	1882.0
EIF3E	-17384.5	-14613.0
EIF3F	-11169.5	-19680.0
EIF3G	2047.5	-4519.0
EIF3H	-13771.5	-12317.0
EIF3I	-7301.5	-14078.0
EIF3J	-5532.5	-7139.0
EIF3K	3626.5	2149.0
EIF3L	-13142.5	-10441.0
EIF3M	-6314.5	-19912.0
FAU	1029.5	358.0
RPL10A	-2906.5	-3724.0
RPL10L	-16334.5	-11519.0
RPL11	-8109.5	-16403.0
RPL12	-2240.5	-714.0
RPL13	571.5	-223.0
RPL13A	-7169.0	-6194.5
RPL14	-2303.5	2151.0
RPL15	-868.5	261.0
RPL17	1840.5	-4757.0
RPL18	-586.5	499.0
RPL18A	-979.5	-494.0
RPL19	-7251.5	-11176.0
RPL21	-4831.5	-9326.0
RPL22	-5310.5	-7738.0
RPL22L1	-11556.5	-12495.0
RPL23	2913.5	3066.0
RPL23A	626.5	-1277.0
RPL24	-5578.5	-8548.0
RPL26	-1432.5	-4386.0
RPL26L1	-7084.5	-16944.0
RPL27	-1532.5	-406.0
RPL27A	-1524.5	1726.0
RPL28	3929.5	3194.0
RPL29	-2277.5	-3035.0
RPL3	-4092.5	-11340.0
RPL30	-528.5	-248.0
RPL31	-13148.5	-13322.0
RPL32	2638.5	2750.0
RPL34	3994.5	3529.0
RPL35	1466.5	2921.0
RPL35A	4081.5	3721.0
RPL36	-2623.5	-2663.0
RPL36AL	-5460.5	-4233.0
RPL37	-3994.5	-3984.0
RPL37A	-4154.5	-2715.0
RPL38	-15057.5	-18437.0
RPL39L	2140.5	1353.0
RPL3L	-11023.5	-3306.0
RPL4	3769.5	3490.0
RPL41	4003.5	3262.0
RPL5	-2029.5	-7354.0
RPL6	-8585.5	-18755.0
RPL7	-2241.5	1376.0
RPL7A	-2123.5	-1243.0
RPL8	-1223.5	-1317.0
RPL9	-1192.5	-3922.0
RPLP0	-2082.5	255.0
RPLP1	-10891.5	-17514.0
RPLP2	-1960.5	1779.0
RPS10	-3622.5	-8002.0
RPS11	1998.5	2177.0
RPS12	4442.5	3999.0
RPS13	2859.5	-3324.0
RPS14	-3250.5	-11554.0
RPS15	-5736.5	-13164.0
RPS15A	-5843.5	-3391.0
RPS16	-2274.5	1705.0
RPS17	0.5	594.0
RPS18	2312.5	1041.0
RPS19	3500.5	3394.0
RPS2	-2384.5	-1176.0
RPS20	-2002.5	-1705.0
RPS21	1289.5	1172.0
RPS23	1573.5	1255.0
RPS24	-7343.5	-12237.0
RPS25	2765.5	-5634.0
RPS26	-7549.5	-10733.0
RPS27	795.5	1318.0
RPS27A	3945.5	3331.0
RPS27L	1726.5	1431.0
RPS28	-12309.5	-20224.0
RPS29	2499.5	1625.0
RPS3	-2501.5	-968.0
RPS3A	-1000.5	-746.0
RPS5	2320.5	-19598.0
RPS6	-8194.5	-8979.0
RPS7	-6542.5	-9140.0
RPS8	-5881.5	-5504.0
RPS9	-9374.5	-19042.0
RPSA	1312.5	644.0
UBA52	-3287.5	-1797.0

---

---

RHO GTPases activate IQGAPs

RHO GTPases activate IQGAPs

metric	value
setSize	11
pMANOVA	0.0395
p.adjustMANOVA	0.135
s.dist	0.518
s.t	-0.432
s.fry	-0.285
p.t	0.0131
p.fry	0.101

Top 20 genes

Gene	t	fry
RAC1	-19561.5	-19996
CLIP1	-21015.5	-17992
IQGAP1	-18048.5	-17000
IQGAP3	-17688.5	-13413
IQGAP2	-19434.5	-11986
CTNNB1	-18325.5	-11591
CTNNA1	-18965.5	-10679
CDH1	-14860.5	-10617
CDC42	-4538.5	-13348
CALM1	-3142.5	-11117

Click HERE to show all gene set members

All member genes

	t	fry
CALM1	-3142.5	-11117
CDC42	-4538.5	-13348
CDH1	-14860.5	-10617
CLIP1	-21015.5	-17992
CTNNA1	-18965.5	-10679
CTNNB1	-18325.5	-11591
IQGAP1	-18048.5	-17000
IQGAP2	-19434.5	-11986
IQGAP3	-17688.5	-13413
MEN1	2284.5	1153
RAC1	-19561.5	-19996

---

---

Class C/3 (Metabotropic glutamate/pheromone receptors)

Class C/3 (Metabotropic glutamate/pheromone receptors)

metric	value
setSize	39
pMANOVA	1.67e-05
p.adjustMANOVA	0.000299
s.dist	0.516
s.t	-0.426
s.fry	-0.291
p.t	4.06e-06
p.fry	0.00168

Top 20 genes

Gene	t	fry
TAS2R1	-19113.5	-21124
TAS2R20	-20351.5	-19407
TAS2R3	-20396.5	-18194
TAS2R39	-17173.5	-20346
TAS2R42	-18228.5	-18670
GRM1	-19257.5	-17483
TAS2R9	-19797.5	-16782
TAS2R7	-19603.5	-15407
TAS2R50	-20040.5	-15059
TAS2R14	-19526.5	-15152
TAS2R8	-20364.5	-13744
GPRC6A	-19567.5	-14091
TAS2R40	-13787.5	-19931
TAS2R10	-19352.5	-14114
GRM5	-15839.5	-16910
TAS2R16	-12702.5	-20738
TAS2R30	-16154.5	-15164
TAS2R41	-13908.5	-15969
TAS2R46	-17690.5	-11896
GABBR1	-19747.5	-9752

Click HERE to show all gene set members

All member genes

	t	fry
CASR	-9767.5	-7554
GABBR1	-19747.5	-9752
GABBR2	-7919.5	-8125
GPRC6A	-19567.5	-14091
GRM1	-19257.5	-17483
GRM2	-8987.5	-3257
GRM3	-10047.5	-14567
GRM4	-13027.5	-2818
GRM5	-15839.5	-16910
GRM6	-13218.5	-6212
GRM7	-11682.5	-13919
GRM8	-5119.5	-5260
TAS1R1	-6254.5	-5541
TAS1R2	-3280.5	-1362
TAS1R3	-9439.5	-4078
TAS2R1	-19113.5	-21124
TAS2R10	-19352.5	-14114
TAS2R13	-9328.5	-12880
TAS2R14	-19526.5	-15152
TAS2R16	-12702.5	-20738
TAS2R19	-13929.5	-9720
TAS2R20	-20351.5	-19407
TAS2R3	-20396.5	-18194
TAS2R30	-16154.5	-15164
TAS2R31	-13874.5	-10175
TAS2R38	-6937.5	-13724
TAS2R39	-17173.5	-20346
TAS2R4	-8536.5	-6913
TAS2R40	-13787.5	-19931
TAS2R41	-13908.5	-15969
TAS2R42	-18228.5	-18670
TAS2R43	0.5	-11882
TAS2R46	-17690.5	-11896
TAS2R5	-14284.5	-8957
TAS2R50	-20040.5	-15059
TAS2R60	-12242.5	-9896
TAS2R7	-19603.5	-15407
TAS2R8	-20364.5	-13744
TAS2R9	-19797.5	-16782

---

---

Scavenging of heme from plasma

Scavenging of heme from plasma

metric	value
setSize	12
pMANOVA	0.0364
p.adjustMANOVA	0.127
s.dist	0.514
s.t	-0.423
s.fry	-0.292
p.t	0.0112
p.fry	0.0796

Top 20 genes

Gene	t	fry
APOL1	-19942.5	-19618
ALB	-21143.5	-17964
CD163	-16657.5	-20157
HBA1	-13299.5	-20903
HBB	-19007.5	-12525
HPX	-16065.5	-14664
APOA1	-7702.5	-19325
AMBP	-13378.5	-6858
HPR	-14225.5	-6010
HP	-12743.5	-5995
JCHAIN	-5804.5	-3986
LRP1	-5842.5	-2057

Click HERE to show all gene set members

All member genes

	t	fry
ALB	-21143.5	-17964
AMBP	-13378.5	-6858
APOA1	-7702.5	-19325
APOL1	-19942.5	-19618
CD163	-16657.5	-20157
HBA1	-13299.5	-20903
HBB	-19007.5	-12525
HP	-12743.5	-5995
HPR	-14225.5	-6010
HPX	-16065.5	-14664
JCHAIN	-5804.5	-3986
LRP1	-5842.5	-2057

---

---

Thyroxine biosynthesis

Thyroxine biosynthesis

metric	value
setSize	10
pMANOVA	0.106
p.adjustMANOVA	0.26
s.dist	0.511
s.t	-0.383
s.fry	-0.338
p.t	0.0359
p.fry	0.064

Top 20 genes

Gene	t	fry
CGA	-21179.5	-17019
DUOX1	-19880.5	-14966
TSHB	-19636.5	-14797
DIO3	-17311.5	-16044
SLC5A5	-11206.5	-15651
IYD	-9322.5	-18427
DIO2	-8978.5	-11880
DIO1	-8969.5	-8931
TPO	-12250.5	-5116
DUOX2	-4368.5	-8133

Click HERE to show all gene set members

All member genes

	t	fry
CGA	-21179.5	-17019
DIO1	-8969.5	-8931
DIO2	-8978.5	-11880
DIO3	-17311.5	-16044
DUOX1	-19880.5	-14966
DUOX2	-4368.5	-8133
IYD	-9322.5	-18427
SLC5A5	-11206.5	-15651
TPO	-12250.5	-5116
TSHB	-19636.5	-14797

---

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

metric	value
setSize	89
pMANOVA	3.26e-10
p.adjustMANOVA	1.57e-08
s.dist	0.51
s.t	0.405
s.fry	0.311
p.t	4.04e-11
p.fry	3.88e-07

Top 20 genes

Gene	t	fry
RPS12	4442.5	3999
RPL35A	4081.5	3721
RPL34	3994.5	3529
RPL4	3769.5	3490
RPS27A	3945.5	3331
RPL41	4003.5	3262
RPL28	3929.5	3194
RPS19	3500.5	3394
RPL23	2913.5	3066
RPL32	2638.5	2750
RPS11	1998.5	2177
RPL35	1466.5	2921
RPS29	2499.5	1625
RPL39L	2140.5	1353
RPS27L	1726.5	1431
RPS18	2312.5	1041
RPS23	1573.5	1255
RPS21	1289.5	1172
RPS27	795.5	1318
RPSA	1312.5	644

Click HERE to show all gene set members

All member genes

	t	fry
EIF4G1	-7345.5	-4999.0
ETF1	-5582.5	-7950.0
FAU	1029.5	358.0
GSPT1	-9077.5	-13937.0
NCBP1	-11783.5	-19711.0
NCBP2	-13668.5	-19914.0
PABPC1	-17586.5	-10991.0
RPL10A	-2906.5	-3724.0
RPL10L	-16334.5	-11519.0
RPL11	-8109.5	-16403.0
RPL12	-2240.5	-714.0
RPL13	571.5	-223.0
RPL13A	-7169.0	-6194.5
RPL14	-2303.5	2151.0
RPL15	-868.5	261.0
RPL17	1840.5	-4757.0
RPL18	-586.5	499.0
RPL18A	-979.5	-494.0
RPL19	-7251.5	-11176.0
RPL21	-4831.5	-9326.0
RPL22	-5310.5	-7738.0
RPL22L1	-11556.5	-12495.0
RPL23	2913.5	3066.0
RPL23A	626.5	-1277.0
RPL24	-5578.5	-8548.0
RPL26	-1432.5	-4386.0
RPL26L1	-7084.5	-16944.0
RPL27	-1532.5	-406.0
RPL27A	-1524.5	1726.0
RPL28	3929.5	3194.0
RPL29	-2277.5	-3035.0
RPL3	-4092.5	-11340.0
RPL30	-528.5	-248.0
RPL31	-13148.5	-13322.0
RPL32	2638.5	2750.0
RPL34	3994.5	3529.0
RPL35	1466.5	2921.0
RPL35A	4081.5	3721.0
RPL36	-2623.5	-2663.0
RPL36AL	-5460.5	-4233.0
RPL37	-3994.5	-3984.0
RPL37A	-4154.5	-2715.0
RPL38	-15057.5	-18437.0
RPL39L	2140.5	1353.0
RPL3L	-11023.5	-3306.0
RPL4	3769.5	3490.0
RPL41	4003.5	3262.0
RPL5	-2029.5	-7354.0
RPL6	-8585.5	-18755.0
RPL7	-2241.5	1376.0
RPL7A	-2123.5	-1243.0
RPL8	-1223.5	-1317.0
RPL9	-1192.5	-3922.0
RPLP0	-2082.5	255.0
RPLP1	-10891.5	-17514.0
RPLP2	-1960.5	1779.0
RPS10	-3622.5	-8002.0
RPS11	1998.5	2177.0
RPS12	4442.5	3999.0
RPS13	2859.5	-3324.0
RPS14	-3250.5	-11554.0
RPS15	-5736.5	-13164.0
RPS15A	-5843.5	-3391.0
RPS16	-2274.5	1705.0
RPS17	0.5	594.0
RPS18	2312.5	1041.0
RPS19	3500.5	3394.0
RPS2	-2384.5	-1176.0
RPS20	-2002.5	-1705.0
RPS21	1289.5	1172.0
RPS23	1573.5	1255.0
RPS24	-7343.5	-12237.0
RPS25	2765.5	-5634.0
RPS26	-7549.5	-10733.0
RPS27	795.5	1318.0
RPS27A	3945.5	3331.0
RPS27L	1726.5	1431.0
RPS28	-12309.5	-20224.0
RPS29	2499.5	1625.0
RPS3	-2501.5	-968.0
RPS3A	-1000.5	-746.0
RPS5	2320.5	-19598.0
RPS6	-8194.5	-8979.0
RPS7	-6542.5	-9140.0
RPS8	-5881.5	-5504.0
RPS9	-9374.5	-19042.0
RPSA	1312.5	644.0
UBA52	-3287.5	-1797.0
UPF1	-13937.5	-18616.0

---

---

Vif-mediated degradation of APOBEC3G

Vif-mediated degradation of APOBEC3G

metric	value
setSize	50
pMANOVA	1.97e-05
p.adjustMANOVA	0.00034
s.dist	0.509
s.t	0.352
s.fry	0.368
p.t	1.66e-05
p.fry	6.84e-06

Top 20 genes

Gene	t	fry
UBB	4311.5	3147
RPS27A	3945.5	3331
PSMC2	3633.5	3282
PSMA5	3622.5	3082
PSMC4	3518.5	2489
PSME3	2784.5	2900
PSMD7	3174.5	2061
PSMA2	1921.5	2430
PSMB9	1700.5	1230
PSMD3	1886.5	964
PSMB11	1982.5	636
PSMD12	678.5	1670
PSME1	1438.5	773
PSMB1	713.5	392

Click HERE to show all gene set members

All member genes

	t	fry
APOBEC3G	-12070.5	-8883
CUL5	-12405.5	-8345
PSMA1	-7249.5	-8787
PSMA2	1921.5	2430
PSMA3	-883.5	1117
PSMA4	-1248.5	-912
PSMA5	3622.5	3082
PSMA6	-3523.5	-2798
PSMA7	-4607.5	-4364
PSMA8	-4253.5	-2545
PSMB1	713.5	392
PSMB10	-9447.5	-8607
PSMB11	1982.5	636
PSMB2	-4046.5	-2961
PSMB3	-2368.5	-1867
PSMB4	-1938.5	-6925
PSMB5	-5107.5	-8535
PSMB6	-5511.5	-14238
PSMB7	-7935.5	-3197
PSMB8	-1609.5	-1641
PSMB9	1700.5	1230
PSMC1	-995.5	-520
PSMC2	3633.5	3282
PSMC3	-5003.5	-3621
PSMC4	3518.5	2489
PSMC5	-5616.5	-8155
PSMC6	-9203.5	-11150
PSMD1	-21024.5	-14763
PSMD11	-2579.5	-955
PSMD12	678.5	1670
PSMD13	-4590.5	-4837
PSMD14	-19831.5	-20698
PSMD2	-5162.5	-5850
PSMD3	1886.5	964
PSMD4	2425.5	-1895
PSMD5	-531.5	-236
PSMD6	-19512.5	-16261
PSMD7	3174.5	2061
PSMD8	-12774.5	-21155
PSMD9	-7505.5	-4424
PSME1	1438.5	773
PSME2	-500.5	105
PSME3	2784.5	2900
PSME4	-14980.5	-16231
PSMF1	-8946.5	-7306
RBX1	-5294.5	-4540
RPS27A	3945.5	3331
UBA52	-3287.5	-1797
UBB	4311.5	3147
UBC	815.5	-1813

---

---

Uptake and function of anthrax toxins

Uptake and function of anthrax toxins

metric	value
setSize	11
pMANOVA	0.0908
p.adjustMANOVA	0.238
s.dist	0.509
s.t	-0.372
s.fry	-0.347
p.t	0.0326
p.fry	0.0464

Top 20 genes

Gene	t	fry
ANTXR2	-19415.5	-19024
MAP2K1	-18453.5	-19687
MAP2K4	-21142.5	-15812
MAP2K6	-17740.5	-16347
PDCD6IP	-13321.5	-21226
FURIN	-20287.5	-12338
MAP2K3	-8839.5	-10008
ANTXR1	-9541.5	-7270
MAP2K2	-7988.5	-6930
CALM1	-3142.5	-11117
MAP2K7	-4976.5	-5529

Click HERE to show all gene set members

All member genes

	t	fry
ANTXR1	-9541.5	-7270
ANTXR2	-19415.5	-19024
CALM1	-3142.5	-11117
FURIN	-20287.5	-12338
MAP2K1	-18453.5	-19687
MAP2K2	-7988.5	-6930
MAP2K3	-8839.5	-10008
MAP2K4	-21142.5	-15812
MAP2K6	-17740.5	-16347
MAP2K7	-4976.5	-5529
PDCD6IP	-13321.5	-21226

---

---

Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation

metric	value
setSize	48
pMANOVA	3.44e-05
p.adjustMANOVA	0.000475
s.dist	0.507
s.t	0.355
s.fry	0.361
p.t	2.05e-05
p.fry	1.48e-05

Top 20 genes

Gene	t	fry
UBB	4311.5	3147
RPS27A	3945.5	3331
PSMC2	3633.5	3282
PSMA5	3622.5	3082
PSMC4	3518.5	2489
PSME3	2784.5	2900
PSMD7	3174.5	2061
PSMA2	1921.5	2430
PSMB9	1700.5	1230
PSMD3	1886.5	964
PSMB11	1982.5	636
PSMD12	678.5	1670
PSME1	1438.5	773
PSMB1	713.5	392

Click HERE to show all gene set members

All member genes

	t	fry
PAK2	-20027.5	-17613
PSMA1	-7249.5	-8787
PSMA2	1921.5	2430
PSMA3	-883.5	1117
PSMA4	-1248.5	-912
PSMA5	3622.5	3082
PSMA6	-3523.5	-2798
PSMA7	-4607.5	-4364
PSMA8	-4253.5	-2545
PSMB1	713.5	392
PSMB10	-9447.5	-8607
PSMB11	1982.5	636
PSMB2	-4046.5	-2961
PSMB3	-2368.5	-1867
PSMB4	-1938.5	-6925
PSMB5	-5107.5	-8535
PSMB6	-5511.5	-14238
PSMB7	-7935.5	-3197
PSMB8	-1609.5	-1641
PSMB9	1700.5	1230
PSMC1	-995.5	-520
PSMC2	3633.5	3282
PSMC3	-5003.5	-3621
PSMC4	3518.5	2489
PSMC5	-5616.5	-8155
PSMC6	-9203.5	-11150
PSMD1	-21024.5	-14763
PSMD11	-2579.5	-955
PSMD12	678.5	1670
PSMD13	-4590.5	-4837
PSMD14	-19831.5	-20698
PSMD2	-5162.5	-5850
PSMD3	1886.5	964
PSMD4	2425.5	-1895
PSMD5	-531.5	-236
PSMD6	-19512.5	-16261
PSMD7	3174.5	2061
PSMD8	-12774.5	-21155
PSMD9	-7505.5	-4424
PSME1	1438.5	773
PSME2	-500.5	105
PSME3	2784.5	2900
PSME4	-14980.5	-16231
PSMF1	-8946.5	-7306
RPS27A	3945.5	3331
UBA52	-3287.5	-1797
UBB	4311.5	3147
UBC	815.5	-1813

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
##  [1] grid      stats4    parallel  stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.0                                      
##  [2] GGally_2.1.2                                       
##  [3] ggplot2_3.3.6                                      
##  [4] gtools_3.9.3                                       
##  [5] tibble_3.1.8                                       
##  [6] dplyr_1.0.10                                       
##  [7] echarts4r_0.4.4                                    
##  [8] tictoc_1.1                                         
##  [9] kableExtra_1.3.4                                   
## [10] data.table_1.14.2                                  
## [11] ENmix_1.32.0                                       
## [12] doParallel_1.0.17                                  
## [13] qqman_0.1.8                                        
## [14] RCircos_1.2.2                                      
## [15] beeswarm_0.4.0                                     
## [16] forestplot_3.1.0                                   
## [17] abind_1.4-5                                        
## [18] checkmate_2.1.0                                    
## [19] reshape2_1.4.4                                     
## [20] gplots_3.1.3                                       
## [21] eulerr_6.1.1                                       
## [22] GEOquery_2.64.2                                    
## [23] RColorBrewer_1.1-3                                 
## [24] IlluminaHumanMethylation450kmanifest_0.4.0         
## [25] topconfects_1.12.0                                 
## [26] DMRcatedata_2.14.0                                 
## [27] ExperimentHub_2.4.0                                
## [28] AnnotationHub_3.4.0                                
## [29] BiocFileCache_2.4.0                                
## [30] dbplyr_2.2.1                                       
## [31] DMRcate_2.10.0                                     
## [32] limma_3.52.4                                       
## [33] missMethyl_1.30.0                                  
## [34] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [35] R.utils_2.12.0                                     
## [36] R.oo_1.25.0                                        
## [37] R.methodsS3_1.8.2                                  
## [38] plyr_1.8.7                                         
## [39] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [40] minfi_1.42.0                                       
## [41] bumphunter_1.38.0                                  
## [42] locfit_1.5-9.6                                     
## [43] iterators_1.0.14                                   
## [44] foreach_1.5.2                                      
## [45] Biostrings_2.64.1                                  
## [46] XVector_0.36.0                                     
## [47] SummarizedExperiment_1.26.1                        
## [48] Biobase_2.56.0                                     
## [49] MatrixGenerics_1.8.1                               
## [50] matrixStats_0.62.0                                 
## [51] GenomicRanges_1.48.0                               
## [52] GenomeInfoDb_1.32.4                                
## [53] IRanges_2.30.1                                     
## [54] S4Vectors_0.34.0                                   
## [55] BiocGenerics_0.42.0                                
## [56] mitch_1.8.0                                        
## 
## loaded via a namespace (and not attached):
##   [1] rappdirs_0.3.3                rtracklayer_1.56.1           
##   [3] tidyr_1.2.1                   bit64_4.0.5                  
##   [5] knitr_1.40                    DelayedArray_0.22.0          
##   [7] rpart_4.1.16                  KEGGREST_1.36.3              
##   [9] RCurl_1.98-1.9                AnnotationFilter_1.20.0      
##  [11] generics_0.1.3                GenomicFeatures_1.48.4       
##  [13] preprocessCore_1.58.0         RSQLite_2.2.18               
##  [15] bit_4.0.4                     tzdb_0.3.0                   
##  [17] webshot_0.5.4                 xml2_1.3.3                   
##  [19] httpuv_1.6.6                  assertthat_0.2.1             
##  [21] xfun_0.33                     hms_1.1.2                    
##  [23] jquerylib_0.1.4               evaluate_0.17                
##  [25] promises_1.2.0.1              fansi_1.0.3                  
##  [27] restfulr_0.0.15               scrime_1.3.5                 
##  [29] progress_1.2.2                caTools_1.18.2               
##  [31] readxl_1.4.1                  DBI_1.1.3                    
##  [33] geneplotter_1.74.0            htmlwidgets_1.5.4            
##  [35] reshape_0.8.9                 purrr_0.3.5                  
##  [37] ellipsis_0.3.2                backports_1.4.1              
##  [39] permute_0.9-7                 calibrate_1.7.7              
##  [41] annotate_1.74.0               biomaRt_2.52.0               
##  [43] deldir_1.0-6                  sparseMatrixStats_1.8.0      
##  [45] vctrs_0.4.2                   ensembldb_2.20.2             
##  [47] withr_2.5.0                   cachem_1.0.6                 
##  [49] Gviz_1.40.1                   BSgenome_1.64.0              
##  [51] GenomicAlignments_1.32.1      prettyunits_1.1.1            
##  [53] mclust_5.4.10                 svglite_2.1.0                
##  [55] cluster_2.1.4                 RPMM_1.25                    
##  [57] lazyeval_0.2.2                crayon_1.5.2                 
##  [59] genefilter_1.78.0             labeling_0.4.2               
##  [61] edgeR_3.38.4                  pkgconfig_2.0.3              
##  [63] nlme_3.1-160                  ProtGenerics_1.28.0          
##  [65] nnet_7.3-18                   rlang_1.0.6                  
##  [67] lifecycle_1.0.3               filelock_1.0.2               
##  [69] dichromat_2.0-0.1             polyclip_1.10-0              
##  [71] cellranger_1.1.0              rngtools_1.5.2               
##  [73] base64_2.0.1                  Matrix_1.5-1                 
##  [75] Rhdf5lib_1.18.2               base64enc_0.1-3              
##  [77] viridisLite_0.4.1             png_0.1-7                    
##  [79] rjson_0.2.21                  bitops_1.0-7                 
##  [81] KernSmooth_2.23-20            rhdf5filters_1.8.0           
##  [83] blob_1.2.3                    DelayedMatrixStats_1.18.1    
##  [85] doRNG_1.8.2                   stringr_1.4.1                
##  [87] nor1mix_1.3-0                 readr_2.1.3                  
##  [89] jpeg_0.1-9                    scales_1.2.1                 
##  [91] memoise_2.0.1                 magrittr_2.0.3               
##  [93] zlibbioc_1.42.0               compiler_4.2.1               
##  [95] BiocIO_1.6.0                  illuminaio_0.38.0            
##  [97] Rsamtools_2.12.0              cli_3.4.1                    
##  [99] DSS_2.44.0                    htmlTable_2.4.1              
## [101] Formula_1.2-4                 MASS_7.3-58.1                
## [103] tidyselect_1.2.0              stringi_1.7.8                
## [105] highr_0.9                     yaml_2.3.5                   
## [107] askpass_1.1                   latticeExtra_0.6-30          
## [109] sass_0.4.2                    VariantAnnotation_1.42.1     
## [111] tools_4.2.1                   rstudioapi_0.14              
## [113] foreign_0.8-83                bsseq_1.32.0                 
## [115] gridExtra_2.3                 farver_2.1.1                 
## [117] digest_0.6.29                 BiocManager_1.30.18          
## [119] shiny_1.7.2                   quadprog_1.5-8               
## [121] Rcpp_1.0.9                    siggenes_1.70.0              
## [123] BiocVersion_3.15.2            later_1.3.0                  
## [125] org.Hs.eg.db_3.15.0           httr_1.4.4                   
## [127] AnnotationDbi_1.58.0          biovizBase_1.44.0            
## [129] colorspace_2.0-3              polylabelr_0.2.0             
## [131] rvest_1.0.3                   XML_3.99-0.11                
## [133] splines_4.2.1                 statmod_1.4.37               
## [135] multtest_2.52.0               systemfonts_1.0.4            
## [137] xtable_1.8-4                  jsonlite_1.8.2               
## [139] dynamicTreeCut_1.63-1         R6_2.5.1                     
## [141] Hmisc_4.7-1                   pillar_1.8.1                 
## [143] htmltools_0.5.3               mime_0.12                    
## [145] glue_1.6.2                    fastmap_1.1.0                
## [147] BiocParallel_1.30.4           interactiveDisplayBase_1.34.0
## [149] beanplot_1.3.1                codetools_0.2-18             
## [151] utf8_1.2.2                    lattice_0.20-45              
## [153] bslib_0.4.0                   curl_4.3.3                   
## [155] openssl_2.0.3                 interp_1.1-3                 
## [157] survival_3.4-0                rmarkdown_2.17               
## [159] munsell_0.5.0                 rhdf5_2.40.0                 
## [161] GenomeInfoDbData_1.2.8        HDF5Array_1.24.2             
## [163] impute_1.70.0                 gtable_0.3.1

END of report