Mitch Report

date generated: 2021-06-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##        t0_crp_RNA t0_crp_meth pod_crp_RNA pod_crp_meth
## A1BG  -3.00456260   0.9487855   0.2301905  0.100632259
## AAAS  -0.21556406   0.4334437   0.1059355  0.230035602
## AACS  -1.05346370   0.8690806   0.2587493  0.682403328
## AAGAB  1.57942406   0.5727567   0.8530991  0.001540913
## AAK1  -0.09752886   0.7201373  -1.5284346  0.360863030
## AAMDC -1.53003779   0.8935852   0.3093931  0.383673218

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	9281
duplicated_genes_present	0
num_profile_genes_in_sets	5590
num_profile_genes_not_in_sets	3691

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2484
num_genesets_excluded	1323
num_genesets_included	1161

Genes by sector

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth	Count
1	-1	-1	-1	-1	101
2	1	-1	-1	-1	92
3	-1	1	-1	-1	375
4	1	1	-1	-1	344
5	-1	-1	1	-1	101
6	1	-1	1	-1	120
7	-1	1	1	-1	450
8	1	1	1	-1	415
9	-1	-1	1	0	1
10	-1	-1	-1	1	122
11	1	-1	-1	1	122
12	-1	0	-1	1	1
13	-1	1	-1	1	1763
14	0	1	-1	1	1
15	1	1	-1	1	1770
16	-1	1	0	1	1
17	-1	-1	1	1	101
18	1	-1	1	1	101
19	-1	1	1	1	1732
20	1	1	1	1	1568

Number of significant gene sets (FDR<0.05)= 310

Gene sets by sector

Gene sets by sector

	s.t0_crp_RNA	s.t0_crp_meth	s.pod_crp_RNA	s.pod_crp_meth	Count
1	-1	-1	-1	-1	1
2	1	-1	-1	-1	8
3	1	1	-1	-1	1
4	-1	-1	1	-1	8
5	1	-1	1	-1	6
6	-1	1	1	-1	25
7	1	1	1	-1	11
8	-1	-1	-1	1	34
9	1	-1	-1	1	29
10	-1	1	-1	1	2
11	1	1	-1	1	48
12	-1	-1	1	1	16
13	1	-1	1	1	61
14	-1	1	1	1	41
15	1	1	1	1	19

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 30 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.t0_crp_RNA	s.t0_crp_meth	s.pod_crp_RNA	s.pod_crp_meth	p.t0_crp_RNA	p.t0_crp_meth	p.pod_crp_RNA	p.pod_crp_meth
Eukaryotic Translation Elongation	70	7.69e-38	8.93e-35	0.935	-0.62500	-0.09000	-0.658	0.20500	1.50e-19	0.1940	1.73e-21	3.04e-03
Neutrophil degranulation	305	1.65e-35	9.58e-33	0.439	-0.02440	-0.02700	0.432	-0.06370	4.69e-01	0.4210	3.42e-38	5.80e-02
Peptide chain elongation	67	2.56e-35	9.90e-33	0.923	-0.61000	-0.10200	-0.653	0.20800	5.99e-18	0.1480	2.26e-20	3.29e-03
Formation of a pool of free 40S subunits	76	4.35e-34	1.12e-31	0.853	-0.55000	-0.08240	-0.621	0.18200	1.11e-16	0.2150	8.44e-21	6.21e-03
rRNA processing	159	4.81e-34	1.12e-31	0.593	-0.24000	-0.06210	-0.524	0.12300	1.88e-07	0.1780	4.58e-30	7.84e-03
rRNA processing in the nucleus and cytosol	154	8.88e-34	1.72e-31	0.601	-0.24700	-0.06040	-0.528	0.13300	1.42e-07	0.1980	1.50e-29	4.57e-03
Major pathway of rRNA processing in the nucleolus and cytosol	147	3.30e-33	5.48e-31	0.609	-0.23900	-0.06700	-0.540	0.13500	6.34e-07	0.1630	1.54e-29	5.04e-03
Selenocysteine synthesis	68	4.67e-32	6.78e-30	0.876	-0.58500	-0.06580	-0.622	0.18400	7.35e-17	0.3490	7.45e-19	8.82e-03
Viral mRNA Translation	67	1.62e-31	2.09e-29	0.876	-0.56900	-0.08150	-0.623	0.22000	7.86e-16	0.2500	1.18e-18	1.89e-03
Eukaryotic Translation Termination	70	2.46e-31	2.86e-29	0.852	-0.56400	-0.08150	-0.613	0.15800	3.47e-16	0.2390	7.08e-19	2.24e-02
Innate Immune System	616	2.03e-30	2.14e-28	0.288	-0.01050	-0.00718	0.287	0.00104	6.62e-01	0.7660	4.70e-33	9.66e-01
L13a-mediated translational silencing of Ceruloplasmin expression	85	1.24e-29	1.20e-27	0.757	-0.47200	-0.05410	-0.558	0.19000	5.85e-14	0.3900	6.43e-19	2.46e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	72	1.02e-28	8.69e-27	0.808	-0.51200	-0.07390	-0.586	0.20600	6.27e-14	0.2790	8.03e-18	2.58e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	86	1.05e-28	8.69e-27	0.742	-0.45100	-0.04390	-0.555	0.19500	5.30e-13	0.4830	6.36e-19	1.78e-03
Selenoamino acid metabolism	76	2.14e-27	1.66e-25	0.767	-0.51300	-0.08420	-0.538	0.16600	1.12e-14	0.2050	5.05e-16	1.24e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency	76	7.66e-27	5.56e-25	0.761	-0.48000	-0.06350	-0.563	0.16700	5.13e-13	0.3390	2.20e-17	1.20e-02
Cap-dependent Translation Initiation	93	7.50e-26	4.84e-24	0.679	-0.40800	-0.04090	-0.506	0.19300	1.19e-11	0.4960	3.40e-17	1.33e-03
Eukaryotic Translation Initiation	93	7.50e-26	4.84e-24	0.679	-0.40800	-0.04090	-0.506	0.19300	1.19e-11	0.4960	3.40e-17	1.33e-03
Influenza Viral RNA Transcription and Replication	110	1.08e-25	6.59e-24	0.626	-0.32100	-0.03140	-0.492	0.21500	6.52e-09	0.5700	5.69e-19	1.03e-04
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	86	1.31e-24	7.22e-23	0.689	-0.40700	-0.05420	-0.511	0.21500	7.72e-11	0.3870	2.86e-16	5.78e-04
Nonsense-Mediated Decay (NMD)	86	1.31e-24	7.22e-23	0.689	-0.40700	-0.05420	-0.511	0.21500	7.72e-11	0.3870	2.86e-16	5.78e-04
Immune System	1142	3.00e-22	1.58e-20	0.184	0.03580	-0.01120	0.176	0.03490	4.95e-02	0.5380	3.52e-22	5.55e-02
SRP-dependent cotranslational protein targeting to membrane	85	1.04e-21	5.26e-20	0.650	-0.33900	-0.09140	-0.507	0.20500	6.85e-08	0.1460	6.97e-16	1.13e-03
Influenza Infection	128	1.43e-21	6.90e-20	0.535	-0.23300	-0.02970	-0.434	0.20700	5.78e-06	0.5640	2.76e-17	5.63e-05
Metabolism of RNA	535	3.65e-20	1.69e-18	0.257	0.00411	-0.04120	-0.234	0.09640	8.73e-01	0.1100	7.18e-20	1.76e-04
Translation	234	7.39e-19	3.30e-17	0.366	-0.11700	-0.08780	-0.332	0.04730	2.30e-03	0.0217	3.10e-18	2.16e-01
Membrane Trafficking	436	2.18e-14	9.39e-13	0.237	0.01270	0.03890	0.233	-0.00230	6.54e-01	0.1690	1.50e-16	9.35e-01
Vesicle-mediated transport	442	6.28e-14	2.60e-12	0.232	0.01520	0.04080	0.227	0.00407	5.89e-01	0.1470	5.80e-16	8.85e-01
Gene expression (Transcription)	1002	7.09e-14	2.84e-12	0.163	0.06810	0.02490	-0.123	0.07880	4.23e-04	0.1980	1.83e-10	4.43e-05
Regulation of expression of SLITs and ROBOs	122	7.41e-14	2.87e-12	0.437	-0.28000	-0.05040	-0.269	0.19500	9.97e-08	0.3390	3.26e-07	2.02e-04

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.t0_crp_RNA	s.t0_crp_meth	s.pod_crp_RNA	s.pod_crp_meth	p.t0_crp_RNA	p.t0_crp_meth	p.pod_crp_RNA	p.pod_crp_meth
Eukaryotic Translation Elongation	70	7.69e-38	8.93e-35	0.9350	-6.25e-01	-9.00e-02	-0.658000	0.205000	1.50e-19	0.19400	1.73e-21	3.04e-03
Neutrophil degranulation	305	1.65e-35	9.58e-33	0.4390	-2.44e-02	-2.70e-02	0.432000	-0.063700	4.69e-01	0.42100	3.42e-38	5.80e-02
Peptide chain elongation	67	2.56e-35	9.90e-33	0.9230	-6.10e-01	-1.02e-01	-0.653000	0.208000	5.99e-18	0.14800	2.26e-20	3.29e-03
Formation of a pool of free 40S subunits	76	4.35e-34	1.12e-31	0.8530	-5.50e-01	-8.24e-02	-0.621000	0.182000	1.11e-16	0.21500	8.44e-21	6.21e-03
rRNA processing	159	4.81e-34	1.12e-31	0.5930	-2.40e-01	-6.21e-02	-0.524000	0.123000	1.88e-07	0.17800	4.58e-30	7.84e-03
rRNA processing in the nucleus and cytosol	154	8.88e-34	1.72e-31	0.6010	-2.47e-01	-6.04e-02	-0.528000	0.133000	1.42e-07	0.19800	1.50e-29	4.57e-03
Major pathway of rRNA processing in the nucleolus and cytosol	147	3.30e-33	5.48e-31	0.6090	-2.39e-01	-6.70e-02	-0.540000	0.135000	6.34e-07	0.16300	1.54e-29	5.04e-03
Selenocysteine synthesis	68	4.67e-32	6.78e-30	0.8760	-5.85e-01	-6.58e-02	-0.622000	0.184000	7.35e-17	0.34900	7.45e-19	8.82e-03
Viral mRNA Translation	67	1.62e-31	2.09e-29	0.8760	-5.69e-01	-8.15e-02	-0.623000	0.220000	7.86e-16	0.25000	1.18e-18	1.89e-03
Eukaryotic Translation Termination	70	2.46e-31	2.86e-29	0.8520	-5.64e-01	-8.15e-02	-0.613000	0.158000	3.47e-16	0.23900	7.08e-19	2.24e-02
Innate Immune System	616	2.03e-30	2.14e-28	0.2880	-1.05e-02	-7.18e-03	0.287000	0.001040	6.62e-01	0.76600	4.70e-33	9.66e-01
L13a-mediated translational silencing of Ceruloplasmin expression	85	1.24e-29	1.20e-27	0.7570	-4.72e-01	-5.41e-02	-0.558000	0.190000	5.85e-14	0.39000	6.43e-19	2.46e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	72	1.02e-28	8.69e-27	0.8080	-5.12e-01	-7.39e-02	-0.586000	0.206000	6.27e-14	0.27900	8.03e-18	2.58e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	86	1.05e-28	8.69e-27	0.7420	-4.51e-01	-4.39e-02	-0.555000	0.195000	5.30e-13	0.48300	6.36e-19	1.78e-03
Selenoamino acid metabolism	76	2.14e-27	1.66e-25	0.7670	-5.13e-01	-8.42e-02	-0.538000	0.166000	1.12e-14	0.20500	5.05e-16	1.24e-02
Response of EIF2AK4 (GCN2) to amino acid deficiency	76	7.66e-27	5.56e-25	0.7610	-4.80e-01	-6.35e-02	-0.563000	0.167000	5.13e-13	0.33900	2.20e-17	1.20e-02
Cap-dependent Translation Initiation	93	7.50e-26	4.84e-24	0.6790	-4.08e-01	-4.09e-02	-0.506000	0.193000	1.19e-11	0.49600	3.40e-17	1.33e-03
Eukaryotic Translation Initiation	93	7.50e-26	4.84e-24	0.6790	-4.08e-01	-4.09e-02	-0.506000	0.193000	1.19e-11	0.49600	3.40e-17	1.33e-03
Influenza Viral RNA Transcription and Replication	110	1.08e-25	6.59e-24	0.6260	-3.21e-01	-3.14e-02	-0.492000	0.215000	6.52e-09	0.57000	5.69e-19	1.03e-04
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	86	1.31e-24	7.22e-23	0.6890	-4.07e-01	-5.42e-02	-0.511000	0.215000	7.72e-11	0.38700	2.86e-16	5.78e-04
Nonsense-Mediated Decay (NMD)	86	1.31e-24	7.22e-23	0.6890	-4.07e-01	-5.42e-02	-0.511000	0.215000	7.72e-11	0.38700	2.86e-16	5.78e-04
Immune System	1142	3.00e-22	1.58e-20	0.1840	3.58e-02	-1.12e-02	0.176000	0.034900	4.95e-02	0.53800	3.52e-22	5.55e-02
SRP-dependent cotranslational protein targeting to membrane	85	1.04e-21	5.26e-20	0.6500	-3.39e-01	-9.14e-02	-0.507000	0.205000	6.85e-08	0.14600	6.97e-16	1.13e-03
Influenza Infection	128	1.43e-21	6.90e-20	0.5350	-2.33e-01	-2.97e-02	-0.434000	0.207000	5.78e-06	0.56400	2.76e-17	5.63e-05
Metabolism of RNA	535	3.65e-20	1.69e-18	0.2570	4.11e-03	-4.12e-02	-0.234000	0.096400	8.73e-01	0.11000	7.18e-20	1.76e-04
Translation	234	7.39e-19	3.30e-17	0.3660	-1.17e-01	-8.78e-02	-0.332000	0.047300	2.30e-03	0.02170	3.10e-18	2.16e-01
Membrane Trafficking	436	2.18e-14	9.39e-13	0.2370	1.27e-02	3.89e-02	0.233000	-0.002300	6.54e-01	0.16900	1.50e-16	9.35e-01
Vesicle-mediated transport	442	6.28e-14	2.60e-12	0.2320	1.52e-02	4.08e-02	0.227000	0.004070	5.89e-01	0.14700	5.80e-16	8.85e-01
Gene expression (Transcription)	1002	7.09e-14	2.84e-12	0.1630	6.81e-02	2.49e-02	-0.123000	0.078800	4.23e-04	0.19800	1.83e-10	4.43e-05
Regulation of expression of SLITs and ROBOs	122	7.41e-14	2.87e-12	0.4370	-2.80e-01	-5.04e-02	-0.269000	0.195000	9.97e-08	0.33900	3.26e-07	2.02e-04
Formation of the ternary complex, and subsequently, the 43S complex	40	1.46e-12	5.46e-11	0.7230	-4.08e-01	-1.10e-01	-0.560000	0.175000	8.29e-06	0.23000	8.94e-10	5.64e-02
Cell Cycle	514	2.08e-12	7.56e-11	0.2040	1.65e-01	-2.03e-02	-0.104000	0.054500	2.75e-10	0.43900	7.33e-05	3.77e-02
Signal Transduction	1289	2.88e-12	1.01e-10	0.1310	-3.62e-02	1.41e-02	0.114000	0.052300	3.69e-02	0.41500	5.43e-11	2.53e-03
Cellular response to starvation	119	3.33e-12	1.14e-10	0.4190	-3.08e-01	-1.24e-03	-0.254000	0.129000	7.17e-09	0.98100	1.91e-06	1.51e-02
Translation initiation complex formation	47	1.34e-10	4.44e-09	0.6160	-3.43e-01	-7.76e-02	-0.476000	0.172000	4.85e-05	0.35800	1.71e-08	4.15e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	48	2.35e-10	7.58e-09	0.6030	-3.44e-01	-7.58e-02	-0.457000	0.176000	3.85e-05	0.36400	4.55e-08	3.47e-02
Signaling by Receptor Tyrosine Kinases	284	3.13e-10	9.82e-09	0.2460	-8.98e-02	4.17e-02	0.222000	0.033000	9.83e-03	0.23100	1.58e-10	3.43e-01
Ribosomal scanning and start codon recognition	47	3.58e-10	1.09e-08	0.6050	-3.32e-01	-6.19e-02	-0.470000	0.178000	8.45e-05	0.46300	2.54e-08	3.49e-02
Cell Cycle, Mitotic	416	4.16e-10	1.24e-08	0.2030	1.67e-01	-2.40e-02	-0.093400	0.063500	7.48e-09	0.40700	1.26e-03	2.83e-02
Cell Cycle Checkpoints	221	1.25e-09	3.64e-08	0.2690	2.40e-01	-1.19e-02	-0.097700	0.072100	9.56e-10	0.76300	1.29e-02	6.66e-02
Metabolism of lipids	427	1.54e-09	4.35e-08	0.1960	2.38e-02	7.08e-02	0.178000	-0.037100	4.06e-01	0.01340	5.10e-10	1.94e-01
Signaling by ROBO receptors	153	3.43e-09	9.49e-08	0.3230	-2.14e-01	-1.72e-02	-0.186000	0.153000	5.15e-06	0.71500	7.75e-05	1.16e-03
rRNA modification in the nucleus and cytosol	47	5.46e-09	1.47e-07	0.5660	-9.69e-02	-1.40e-01	-0.525000	0.123000	2.51e-01	0.09730	4.83e-10	1.44e-01
RNA Polymerase II Transcription	891	6.42e-09	1.69e-07	0.1380	6.41e-02	2.07e-02	-0.100000	0.067500	1.63e-03	0.30800	8.20e-07	9.07e-04
Metabolism	1215	4.09e-08	1.06e-06	0.1130	-6.00e-02	3.46e-02	0.088400	-0.012900	7.28e-04	0.05120	6.48e-07	4.67e-01
Signaling by Interleukins	263	4.28e-08	1.08e-06	0.2170	-3.80e-02	-5.27e-03	0.182000	0.111000	2.92e-01	0.88400	4.30e-07	2.12e-03
Generic Transcription Pathway	799	7.61e-08	1.88e-06	0.1370	3.80e-02	1.93e-02	-0.114000	0.064500	7.52e-02	0.36700	1.06e-07	2.55e-03
Cytokine Signaling in Immune system	424	1.02e-07	2.46e-06	0.1660	7.61e-02	-1.69e-02	0.102000	0.105000	8.02e-03	0.55600	3.96e-04	2.49e-04
Interferon Signaling	142	1.23e-07	2.92e-06	0.2980	2.88e-01	-3.51e-02	-0.031600	0.059600	3.54e-09	0.47200	5.17e-01	2.23e-01
Platelet activation, signaling and aggregation	133	1.35e-07	3.13e-06	0.3070	-1.10e-01	5.35e-02	0.273000	0.068000	2.96e-02	0.28900	5.81e-08	1.78e-01
Nervous system development	305	4.05e-07	9.21e-06	0.1950	-1.71e-01	-2.89e-02	0.026100	0.083600	3.41e-07	0.39100	4.38e-01	1.29e-02
Signaling by NOTCH	129	5.22e-07	1.15e-05	0.2880	-2.53e-02	1.68e-02	0.225000	0.178000	6.21e-01	0.74300	1.12e-05	5.15e-04
Hemostasis	303	5.23e-07	1.15e-05	0.1990	-7.29e-02	7.70e-03	0.184000	-0.012300	3.08e-02	0.81900	4.55e-08	7.15e-01
Metabolism of amino acids and derivatives	218	5.91e-07	1.27e-05	0.2340	-1.53e-01	-3.84e-02	-0.156000	0.075700	1.15e-04	0.33100	8.21e-05	5.57e-02
Antiviral mechanism by IFN-stimulated genes	77	9.89e-07	2.09e-05	0.3820	3.16e-01	-8.74e-02	-0.189000	0.054900	1.77e-06	0.18600	4.20e-03	4.06e-01
Axon guidance	293	1.19e-06	2.47e-05	0.1920	-1.73e-01	-2.89e-02	0.021600	0.076400	4.56e-07	0.40000	5.28e-01	2.58e-02
tRNA processing	93	1.39e-06	2.83e-05	0.3470	1.45e-01	-9.10e-03	-0.304000	0.082500	1.58e-02	0.88000	4.32e-07	1.71e-01
Signaling by WNT	174	2.03e-06	4.06e-05	0.2560	-2.27e-02	1.03e-01	0.129000	0.194000	6.08e-01	0.01980	3.54e-03	1.13e-05
Developmental Biology	449	2.83e-06	5.57e-05	0.1500	-1.23e-01	-2.24e-02	0.051900	0.065600	1.08e-05	0.42300	6.30e-02	1.89e-02
PIP3 activates AKT signaling	181	2.92e-06	5.65e-05	0.2410	-1.12e-01	4.86e-02	0.129000	0.162000	9.67e-03	0.26200	2.94e-03	1.77e-04
EPH-Ephrin signaling	54	3.71e-06	7.07e-05	0.4310	-6.00e-02	-1.29e-02	0.427000	0.015700	4.46e-01	0.87000	5.99e-08	8.43e-01
Intracellular signaling by second messengers	206	5.63e-06	1.06e-04	0.2250	-1.15e-01	6.87e-02	0.124000	0.132000	4.76e-03	0.09140	2.30e-03	1.15e-03
Activation of ATR in response to replication stress	33	5.88e-06	1.08e-04	0.5510	3.01e-01	3.82e-02	-0.445000	0.115000	2.83e-03	0.70400	9.75e-06	2.54e-01
Leishmania infection	110	6.63e-06	1.20e-04	0.3020	-7.02e-02	8.93e-02	0.279000	-0.020800	2.05e-01	0.10700	4.82e-07	7.07e-01
Mitotic Prometaphase	154	8.43e-06	1.51e-04	0.2510	2.15e-01	3.14e-02	-0.119000	0.040600	4.62e-06	0.50300	1.13e-02	3.87e-01
Resolution of Sister Chromatid Cohesion	90	1.17e-05	2.06e-04	0.3250	2.74e-01	-4.81e-02	-0.168000	-0.008570	7.37e-06	0.43100	5.98e-03	8.89e-01
Transport of small molecules	342	1.35e-05	2.35e-04	0.1690	-4.39e-02	-1.54e-02	0.160000	-0.027000	1.68e-01	0.62800	4.87e-07	3.97e-01
Activation of the pre-replicative complex	28	1.52e-05	2.60e-04	0.5810	2.25e-01	5.02e-02	-0.511000	0.151000	3.94e-02	0.64600	2.89e-06	1.67e-01
Degradation of the extracellular matrix	35	1.61e-05	2.71e-04	0.5080	-8.48e-02	2.77e-02	0.500000	0.029400	3.86e-01	0.77700	3.17e-07	7.64e-01
Infectious disease	530	2.07e-05	3.42e-04	0.1310	-6.19e-02	1.30e-03	0.018000	0.114000	1.65e-02	0.96000	4.87e-01	1.02e-05
Metabolism of non-coding RNA	47	2.12e-05	3.42e-04	0.4400	2.29e-01	-2.89e-02	-0.361000	0.104000	6.79e-03	0.73200	1.94e-05	2.16e-01
snRNP Assembly	47	2.12e-05	3.42e-04	0.4400	2.29e-01	-2.89e-02	-0.361000	0.104000	6.79e-03	0.73200	1.94e-05	2.16e-01
Homologous DNA Pairing and Strand Exchange	38	2.48e-05	3.94e-04	0.4790	4.13e-01	6.83e-02	-0.229000	0.033800	1.05e-05	0.46700	1.45e-02	7.19e-01
M Phase	291	2.57e-05	4.03e-04	0.1740	1.56e-01	-1.72e-02	-0.029900	0.068500	5.38e-06	0.61600	3.84e-01	4.63e-02
trans-Golgi Network Vesicle Budding	52	2.63e-05	4.07e-04	0.4160	-3.48e-02	7.86e-02	0.398000	-0.083300	6.65e-01	0.32800	6.89e-07	3.00e-01
Presynaptic phase of homologous DNA pairing and strand exchange	35	2.74e-05	4.19e-04	0.4980	4.44e-01	3.19e-02	-0.223000	0.018100	5.65e-06	0.74400	2.25e-02	8.53e-01
Signaling by GPCR	199	2.81e-05	4.24e-04	0.2130	-1.11e-01	2.83e-02	0.175000	-0.039200	7.47e-03	0.49400	2.21e-05	3.44e-01
MHC class II antigen presentation	70	2.92e-05	4.35e-04	0.3550	8.28e-02	1.02e-01	0.329000	-0.033900	2.32e-01	0.14100	2.08e-06	6.24e-01
Disease	928	3.08e-05	4.52e-04	0.0981	-3.60e-02	5.68e-03	0.058500	0.069800	7.15e-02	0.77600	3.38e-03	4.77e-04
Clathrin-mediated endocytosis	90	3.12e-05	4.52e-04	0.3100	-4.94e-02	5.45e-02	0.297000	0.051100	4.20e-01	0.37300	1.21e-06	4.03e-01
S Phase	138	3.86e-05	5.54e-04	0.2490	1.45e-01	-3.92e-02	-0.142000	0.139000	3.43e-03	0.42800	4.25e-03	5.13e-03
Gene Silencing by RNA	60	3.95e-05	5.59e-04	0.3940	8.93e-02	6.46e-02	-0.248000	0.286000	2.32e-01	0.38800	9.20e-04	1.28e-04
Diseases of signal transduction by growth factor receptors and second messengers	264	4.57e-05	6.39e-04	0.1770	1.47e-02	3.14e-02	0.156000	0.075900	6.83e-01	0.38400	1.48e-05	3.52e-02
GPCR downstream signalling	183	5.54e-05	7.66e-04	0.2160	-9.68e-02	3.13e-02	0.185000	-0.046300	2.47e-02	0.46800	1.80e-05	2.83e-01
Beta-catenin independent WNT signaling	105	5.85e-05	7.88e-04	0.2790	-4.67e-02	7.05e-02	0.167000	0.207000	4.09e-01	0.21400	3.15e-03	2.56e-04
NS1 Mediated Effects on Host Pathways	38	5.87e-05	7.88e-04	0.4710	2.84e-01	3.52e-02	-0.334000	0.168000	2.45e-03	0.70700	3.67e-04	7.33e-02
Programmed Cell Death	153	5.91e-05	7.88e-04	0.2200	8.93e-02	-5.89e-02	0.174000	0.081900	5.79e-02	0.21100	2.25e-04	8.18e-02
G2/M Checkpoints	115	6.33e-05	8.35e-04	0.2670	2.30e-01	9.07e-03	-0.067800	0.115000	2.09e-05	0.86700	2.10e-01	3.36e-02
ISG15 antiviral mechanism	70	7.78e-05	1.01e-03	0.3410	2.65e-01	-7.67e-02	-0.197000	0.033500	1.31e-04	0.26800	4.37e-03	6.29e-01
G1/S Transition	113	7.79e-05	1.01e-03	0.2640	1.72e-01	-4.72e-02	-0.131000	0.145000	1.68e-03	0.38700	1.68e-02	7.76e-03
Rab regulation of trafficking	89	8.25e-05	1.05e-03	0.2980	-9.06e-02	1.95e-02	0.282000	0.029800	1.41e-01	0.75100	4.63e-06	6.28e-01
G2/M DNA damage checkpoint	52	9.26e-05	1.17e-03	0.3860	3.58e-01	4.57e-02	-0.136000	-0.016500	8.15e-06	0.57000	9.11e-02	8.37e-01
Signaling by NTRKs	90	9.81e-05	1.22e-03	0.2940	-1.27e-01	4.35e-02	0.246000	0.086900	3.84e-02	0.47700	5.59e-05	1.56e-01
Mitotic Metaphase and Anaphase	194	1.06e-04	1.31e-03	0.1980	1.75e-01	-4.77e-02	-0.031600	0.073000	2.86e-05	0.25500	4.50e-01	8.14e-02
Interactions of Vpr with host cellular proteins	33	1.15e-04	1.41e-03	0.4970	1.90e-01	8.14e-02	-0.408000	0.193000	5.94e-02	0.41900	4.95e-05	5.58e-02
PTEN Regulation	114	1.27e-04	1.54e-03	0.2490	-6.31e-02	9.65e-03	0.153000	0.185000	2.46e-01	0.85900	4.93e-03	6.51e-04
Cellular responses to external stimuli	457	1.40e-04	1.67e-03	0.1290	-9.12e-02	-1.42e-02	-0.003280	0.090200	9.95e-04	0.60900	9.06e-01	1.12e-03
Cellular responses to stress	452	1.41e-04	1.67e-03	0.1300	-9.23e-02	-1.31e-02	-0.009180	0.090600	9.15e-04	0.63800	7.42e-01	1.13e-03
DNA Repair	239	1.53e-04	1.80e-03	0.1840	1.09e-01	3.85e-02	-0.114000	0.086200	3.93e-03	0.30900	2.66e-03	2.27e-02
tRNA processing in the nucleus	55	1.73e-04	2.00e-03	0.3700	1.99e-01	3.72e-03	-0.307000	0.052700	1.09e-02	0.96200	8.31e-05	5.00e-01
Mitotic Anaphase	193	1.76e-04	2.02e-03	0.1940	1.71e-01	-4.63e-02	-0.026900	0.073200	4.52e-05	0.27000	5.22e-01	8.15e-02
Regulation of actin dynamics for phagocytic cup formation	45	2.02e-04	2.30e-03	0.4050	-4.07e-02	7.24e-02	0.396000	0.000284	6.38e-01	0.40100	4.32e-06	9.97e-01
ER to Golgi Anterograde Transport	105	2.07e-04	2.34e-03	0.2700	7.53e-02	2.64e-03	0.251000	-0.066800	1.84e-01	0.96300	9.52e-06	2.38e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	2.17e-04	2.39e-03	0.8550	2.69e-01	3.42e-01	0.656000	0.332000	1.40e-01	0.06100	3.28e-04	6.93e-02
alpha-linolenic acid (ALA) metabolism	10	2.17e-04	2.39e-03	0.8550	2.69e-01	3.42e-01	0.656000	0.332000	1.40e-01	0.06100	3.28e-04	6.93e-02
Metabolism of carbohydrates	177	2.24e-04	2.46e-03	0.2060	-1.39e-01	6.52e-02	0.138000	-0.004290	1.57e-03	0.13700	1.67e-03	9.22e-01
Transport of the SLBP Dependant Mature mRNA	34	2.29e-04	2.46e-03	0.4710	2.62e-01	7.08e-02	-0.325000	0.207000	8.34e-03	0.47500	1.05e-03	3.68e-02
Signaling by NOTCH4	67	2.29e-04	2.46e-03	0.3020	7.48e-03	-6.76e-02	0.232000	0.181000	9.16e-01	0.33900	1.04e-03	1.06e-02
Interleukin-1 family signaling	98	2.37e-04	2.51e-03	0.2540	1.11e-02	-5.21e-02	0.217000	0.119000	8.50e-01	0.37500	2.09e-04	4.19e-02
Separation of Sister Chromatids	145	2.37e-04	2.51e-03	0.2210	1.97e-01	-5.05e-02	-0.048500	0.071700	4.40e-05	0.29600	3.16e-01	1.38e-01
TCF dependent signaling in response to WNT	117	2.42e-04	2.54e-03	0.2640	-5.34e-02	1.23e-01	0.076600	0.214000	3.20e-01	0.02160	1.54e-01	6.61e-05
Rev-mediated nuclear export of HIV RNA	33	2.45e-04	2.54e-03	0.4800	1.68e-01	6.41e-02	-0.395000	0.206000	9.54e-02	0.52400	8.86e-05	4.11e-02
Mitotic Spindle Checkpoint	96	2.56e-04	2.63e-03	0.2760	2.35e-01	-5.58e-02	-0.133000	-0.003630	7.08e-05	0.34600	2.49e-02	9.51e-01
Interactions of Rev with host cellular proteins	34	2.64e-04	2.69e-03	0.4700	1.81e-01	7.57e-02	-0.383000	0.190000	6.87e-02	0.44500	1.13e-04	5.54e-02
Post-translational protein modification	888	2.74e-04	2.77e-03	0.0915	5.46e-02	6.25e-03	0.064800	0.033900	7.33e-03	0.75900	1.48e-03	9.62e-02
PCP/CE pathway	71	2.81e-04	2.81e-03	0.3140	-1.26e-01	5.88e-02	0.183000	0.213000	6.60e-02	0.39300	7.77e-03	1.94e-03
Interferon alpha/beta signaling	51	3.11e-04	3.08e-03	0.3650	3.39e-01	-7.67e-02	0.012500	0.109000	2.88e-05	0.34400	8.77e-01	1.78e-01
Transport of the SLBP independent Mature mRNA	33	3.29e-04	3.24e-03	0.4700	2.50e-01	5.30e-02	-0.322000	0.228000	1.31e-02	0.59800	1.39e-03	2.36e-02
NEP/NS2 Interacts with the Cellular Export Machinery	30	3.42e-04	3.29e-03	0.4900	2.45e-01	4.42e-02	-0.379000	0.185000	2.01e-02	0.67500	3.35e-04	7.94e-02
Vpr-mediated nuclear import of PICs	32	3.43e-04	3.29e-03	0.4760	1.87e-01	5.91e-02	-0.398000	0.171000	6.67e-02	0.56400	9.74e-05	9.48e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	81	3.46e-04	3.29e-03	0.2940	2.51e-01	-3.93e-02	-0.149000	-0.008620	9.75e-05	0.54200	2.10e-02	8.94e-01
Amplification of signal from the kinetochores	81	3.46e-04	3.29e-03	0.2940	2.51e-01	-3.93e-02	-0.149000	-0.008620	9.75e-05	0.54200	2.10e-02	8.94e-01
Chromosome Maintenance	74	3.56e-04	3.34e-03	0.3160	4.17e-02	4.66e-02	-0.287000	0.116000	5.36e-01	0.48900	2.03e-05	8.58e-02
Signal transduction by L1	11	3.57e-04	3.34e-03	0.7880	-8.79e-02	2.03e-01	0.715000	0.248000	6.14e-01	0.24500	4.01e-05	1.54e-01
Cellular response to chemical stress	116	3.73e-04	3.46e-03	0.2380	-5.00e-03	-5.84e-02	0.230000	0.022600	9.26e-01	0.27900	2.02e-05	6.75e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	53	4.17e-04	3.84e-03	0.3280	6.43e-02	-6.84e-02	0.218000	0.226000	4.19e-01	0.39000	6.21e-03	4.47e-03
Mitotic G1 phase and G1/S transition	127	4.29e-04	3.91e-03	0.2290	1.62e-01	-4.37e-02	-0.103000	0.117000	1.68e-03	0.39700	4.69e-02	2.28e-02
DNA Replication	110	4.31e-04	3.91e-03	0.2460	1.59e-01	-2.64e-02	-0.097900	0.158000	4.04e-03	0.63300	7.71e-02	4.40e-03
Fcgamma receptor (FCGR) dependent phagocytosis	63	4.35e-04	3.92e-03	0.3310	-7.12e-02	8.38e-02	0.308000	-0.047900	3.29e-01	0.25100	2.39e-05	5.11e-01
Regulation of PTEN stability and activity	56	5.09e-04	4.55e-03	0.3290	3.96e-02	1.80e-02	0.240000	0.221000	6.09e-01	0.81600	1.96e-03	4.38e-03
EML4 and NUDC in mitotic spindle formation	85	5.16e-04	4.55e-03	0.2820	2.37e-01	-5.37e-02	-0.144000	0.004310	1.68e-04	0.39300	2.25e-02	9.45e-01
RAB GEFs exchange GTP for GDP on RABs	61	5.17e-04	4.55e-03	0.3340	-3.57e-02	-3.56e-02	0.325000	-0.059700	6.30e-01	0.63100	1.16e-05	4.21e-01
Mitotic G2-G2/M phases	155	5.80e-04	5.07e-03	0.2040	1.82e-01	2.76e-03	0.014700	0.090300	1.01e-04	0.95300	7.54e-01	5.35e-02
Golgi-to-ER retrograde transport	92	6.27e-04	5.41e-03	0.2670	1.15e-01	8.57e-02	0.225000	0.004510	5.73e-02	0.15700	1.99e-04	9.41e-01
COPI-mediated anterograde transport	68	6.30e-04	5.41e-03	0.3160	9.12e-02	-2.39e-02	0.294000	-0.070300	1.95e-01	0.73400	2.91e-05	3.17e-01
Cellular response to hypoxia	60	6.42e-04	5.48e-03	0.3040	2.49e-02	-6.05e-02	0.243000	0.170000	7.39e-01	0.41800	1.13e-03	2.28e-02
Lysosome Vesicle Biogenesis	25	7.16e-04	6.07e-03	0.5100	-1.54e-01	1.13e-01	0.463000	-0.093500	1.83e-01	0.32800	6.08e-05	4.19e-01
FCGR3A-mediated phagocytosis	43	7.32e-04	6.07e-03	0.3870	-7.37e-02	8.10e-02	0.371000	0.010300	4.04e-01	0.35900	2.63e-05	9.07e-01
Leishmania phagocytosis	43	7.32e-04	6.07e-03	0.3870	-7.37e-02	8.10e-02	0.371000	0.010300	4.04e-01	0.35900	2.63e-05	9.07e-01
Parasite infection	43	7.32e-04	6.07e-03	0.3870	-7.37e-02	8.10e-02	0.371000	0.010300	4.04e-01	0.35900	2.63e-05	9.07e-01
Pre-NOTCH Processing in Golgi	15	7.55e-04	6.22e-03	0.6620	-2.68e-01	2.12e-01	0.377000	0.424000	7.25e-02	0.15500	1.16e-02	4.53e-03
PI3K/AKT Signaling in Cancer	50	7.77e-04	6.35e-03	0.3630	-2.79e-01	7.43e-02	0.128000	0.177000	6.46e-04	0.36400	1.17e-01	3.02e-02
E2F mediated regulation of DNA replication	18	7.95e-04	6.45e-03	0.6050	5.02e-01	-2.07e-01	-0.250000	-0.093600	2.27e-04	0.12900	6.66e-02	4.92e-01
Ion channel transport	80	8.38e-04	6.73e-03	0.2880	-2.79e-02	1.30e-02	0.248000	-0.143000	6.67e-01	0.84200	1.28e-04	2.72e-02
G2/M Transition	153	8.44e-04	6.73e-03	0.2010	1.78e-01	3.97e-03	0.011200	0.091500	1.54e-04	0.93300	8.12e-01	5.20e-02
DNA strand elongation	27	8.46e-04	6.73e-03	0.4890	8.30e-02	8.71e-03	-0.470000	0.102000	4.56e-01	0.93800	2.34e-05	3.61e-01
Transport of Ribonucleoproteins into the Host Nucleus	30	8.63e-04	6.79e-03	0.4650	2.41e-01	7.43e-02	-0.355000	0.165000	2.26e-02	0.48200	7.84e-04	1.17e-01
Peptide hormone metabolism	26	8.66e-04	6.79e-03	0.4840	3.79e-01	9.40e-02	0.159000	0.239000	8.39e-04	0.40700	1.61e-01	3.50e-02
HDR through Single Strand Annealing (SSA)	34	9.51e-04	7.41e-03	0.4220	3.70e-01	1.11e-01	-0.166000	0.034300	1.90e-04	0.26500	9.39e-02	7.30e-01
MAP2K and MAPK activation	25	9.67e-04	7.48e-03	0.4860	-4.53e-02	-1.06e-01	0.470000	0.038800	6.95e-01	0.36100	4.75e-05	7.37e-01
Glycosaminoglycan metabolism	61	9.79e-04	7.49e-03	0.3220	-2.14e-01	1.68e-01	0.172000	-0.016300	3.96e-03	0.02390	2.05e-02	8.26e-01
CDC42 GTPase cycle	95	9.80e-04	7.49e-03	0.2570	-7.54e-02	6.24e-02	0.237000	0.013200	2.06e-01	0.29400	6.79e-05	8.24e-01
Golgi Associated Vesicle Biogenesis	39	9.95e-04	7.55e-03	0.4020	-4.16e-02	8.12e-02	0.359000	-0.156000	6.54e-01	0.38100	1.05e-04	9.23e-02
Signaling by NTRK1 (TRKA)	82	1.04e-03	7.82e-03	0.2710	-1.17e-01	3.30e-02	0.228000	0.080400	6.89e-02	0.60600	3.60e-04	2.09e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	41	1.08e-03	8.07e-03	0.3930	2.48e-01	7.37e-02	-0.241000	0.173000	6.03e-03	0.41500	7.76e-03	5.61e-02
Asparagine N-linked glycosylation	222	1.13e-03	8.39e-03	0.1680	4.21e-02	-1.03e-02	0.162000	-0.017700	2.83e-01	0.79300	3.66e-05	6.51e-01
ROS sensing by NFE2L2	48	1.24e-03	9.16e-03	0.3350	6.83e-02	6.87e-03	0.238000	0.226000	4.14e-01	0.93400	4.45e-03	6.90e-03
Extracellular matrix organization	91	1.25e-03	9.16e-03	0.2580	-1.57e-01	2.56e-02	0.202000	-0.026200	1.00e-02	0.67300	8.82e-04	6.67e-01
Neuronal System	128	1.28e-03	9.36e-03	0.2200	-1.32e-01	-4.97e-03	0.132000	-0.116000	1.03e-02	0.92300	1.02e-02	2.40e-02
Transport of Mature Transcript to Cytoplasm	63	1.29e-03	9.36e-03	0.3140	2.10e-01	5.54e-02	-0.160000	0.160000	4.01e-03	0.44800	2.80e-02	2.84e-02
EPHB-mediated forward signaling	24	1.32e-03	9.51e-03	0.5010	1.82e-01	-1.34e-02	0.465000	-0.034800	1.23e-01	0.91000	8.07e-05	7.68e-01
Collagen degradation	14	1.46e-03	1.05e-02	0.6480	-1.17e-01	1.44e-01	0.619000	0.053000	4.49e-01	0.35100	6.12e-05	7.31e-01
Regulation of RUNX3 expression and activity	49	1.48e-03	1.05e-02	0.3080	2.35e-02	-1.12e-01	0.157000	0.239000	7.76e-01	0.17500	5.82e-02	3.86e-03
WNT5A-dependent internalization of FZD4	10	1.51e-03	1.07e-02	0.7420	-5.07e-01	-8.73e-02	0.502000	0.183000	5.48e-03	0.63300	6.02e-03	3.17e-01
Nuclear import of Rev protein	31	1.56e-03	1.09e-02	0.4420	1.94e-01	6.50e-02	-0.363000	0.147000	6.17e-02	0.53200	4.73e-04	1.58e-01
Transport of Mature mRNA Derived from an Intronless Transcript	40	1.58e-03	1.11e-02	0.3890	2.38e-01	5.91e-02	-0.236000	0.189000	9.26e-03	0.51800	9.97e-03	3.90e-02
L1CAM interactions	40	1.66e-03	1.15e-02	0.3810	-8.14e-02	-7.99e-03	0.371000	-0.033500	3.73e-01	0.93000	4.97e-05	7.14e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	54	1.70e-03	1.17e-02	0.3330	1.91e-01	3.37e-02	-0.205000	0.178000	1.55e-02	0.66900	9.41e-03	2.35e-02
Signaling by high-kinase activity BRAF mutants	22	1.70e-03	1.17e-02	0.4920	-1.89e-02	-1.51e-01	0.463000	0.071700	8.78e-01	0.22100	1.72e-04	5.61e-01
Ub-specific processing proteases	131	1.71e-03	1.17e-02	0.2020	1.68e-01	-5.62e-02	0.022400	0.094400	9.45e-04	0.26900	6.60e-01	6.32e-02
Export of Viral Ribonucleoproteins from Nucleus	31	1.72e-03	1.17e-02	0.4380	2.14e-01	2.42e-02	-0.349000	0.154000	3.94e-02	0.81600	7.90e-04	1.37e-01
DNA Double-Strand Break Repair	113	1.77e-03	1.20e-02	0.2290	1.63e-01	3.57e-02	-0.118000	0.105000	2.89e-03	0.51400	3.12e-02	5.55e-02
PPARA activates gene expression	79	1.79e-03	1.20e-02	0.2680	9.23e-02	3.93e-02	0.246000	0.036300	1.57e-01	0.54700	1.63e-04	5.77e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	28	1.83e-03	1.21e-02	0.4600	2.13e-01	4.49e-02	-0.366000	0.175000	5.15e-02	0.68100	8.01e-04	1.09e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	28	1.83e-03	1.21e-02	0.4600	2.13e-01	4.49e-02	-0.366000	0.175000	5.15e-02	0.68100	8.01e-04	1.09e-01
Postmitotic nuclear pore complex (NPC) reformation	26	1.88e-03	1.24e-02	0.4720	2.00e-01	4.47e-02	-0.414000	0.097100	7.80e-02	0.69300	2.63e-04	3.92e-01
Processing of Capped Intron-Containing Pre-mRNA	191	1.93e-03	1.27e-02	0.1770	6.95e-02	1.92e-02	-0.152000	0.055700	9.96e-02	0.65000	3.26e-04	1.87e-01
Transport to the Golgi and subsequent modification	127	1.96e-03	1.28e-02	0.2160	3.12e-02	8.59e-03	0.207000	-0.054300	5.45e-01	0.86800	6.14e-05	2.92e-01
Synthesis of DNA	103	1.97e-03	1.28e-02	0.2330	1.36e-01	-2.24e-02	-0.110000	0.153000	1.77e-02	0.69600	5.47e-02	7.35e-03
Regulation of HSF1-mediated heat shock response	66	1.99e-03	1.28e-02	0.3020	6.32e-02	5.83e-03	-0.234000	0.180000	3.76e-01	0.93500	1.05e-03	1.17e-02
Cargo recognition for clathrin-mediated endocytosis	65	1.99e-03	1.28e-02	0.2940	-6.32e-02	4.15e-02	0.282000	0.032400	3.79e-01	0.56400	8.52e-05	6.53e-01
RHO GTPases Activate ROCKs	13	2.05e-03	1.31e-02	0.6500	9.67e-02	-1.63e-01	0.622000	-0.000133	5.46e-01	0.30900	1.03e-04	9.99e-01
Interleukin-1 signaling	78	2.10e-03	1.33e-02	0.2500	1.90e-02	-7.32e-02	0.215000	0.102000	7.73e-01	0.26500	1.06e-03	1.19e-01
Regulation of RUNX2 expression and activity	57	2.17e-03	1.36e-02	0.2850	9.56e-02	-6.79e-02	0.092100	0.243000	2.13e-01	0.37600	2.30e-01	1.52e-03
Degradation of DVL	48	2.18e-03	1.36e-02	0.3150	1.48e-02	-3.34e-02	0.203000	0.239000	8.60e-01	0.68900	1.51e-02	4.30e-03
Signaling by RAF1 mutants	25	2.18e-03	1.36e-02	0.4480	2.82e-02	-1.51e-01	0.407000	0.106000	8.08e-01	0.19200	4.27e-04	3.61e-01
Adaptive Immune System	475	2.30e-03	1.43e-02	0.1060	4.87e-02	-3.17e-03	0.080600	0.048200	7.36e-02	0.90700	3.04e-03	7.63e-02
SUMOylation of DNA replication proteins	43	2.34e-03	1.44e-02	0.3680	2.05e-01	1.14e-01	-0.234000	0.161000	2.01e-02	0.19600	8.00e-03	6.79e-02
Processing of DNA double-strand break ends	54	2.44e-03	1.50e-02	0.3190	2.66e-01	9.11e-02	-0.133000	0.068400	7.33e-04	0.24800	9.05e-02	3.85e-01
Negative regulation of NOTCH4 signaling	48	2.53e-03	1.54e-02	0.3080	4.89e-02	-5.84e-02	0.192000	0.229000	5.59e-01	0.48400	2.16e-02	6.15e-03
Regulated Necrosis	42	2.54e-03	1.54e-02	0.3260	1.46e-01	-1.84e-01	0.153000	0.168000	1.02e-01	0.03990	8.64e-02	6.05e-02
Cellular response to heat stress	79	2.70e-03	1.63e-02	0.2690	1.17e-02	-1.35e-02	-0.212000	0.165000	8.58e-01	0.83600	1.16e-03	1.13e-02
Stabilization of p53	48	3.03e-03	1.83e-02	0.3000	8.48e-02	-9.86e-02	0.153000	0.222000	3.10e-01	0.23800	6.68e-02	7.83e-03
p75 NTR receptor-mediated signalling	60	3.06e-03	1.83e-02	0.2960	-1.13e-01	5.64e-02	0.248000	0.101000	1.29e-01	0.45100	9.00e-04	1.78e-01
Semaphorin interactions	39	3.17e-03	1.89e-02	0.3770	-6.97e-02	-2.36e-02	0.351000	-0.115000	4.52e-01	0.79900	1.52e-04	2.14e-01
Cross-presentation of soluble exogenous antigens (endosomes)	38	3.28e-03	1.94e-02	0.3490	1.03e-01	-2.10e-02	0.232000	0.238000	2.73e-01	0.82300	1.34e-02	1.12e-02
Extension of Telomeres	44	3.36e-03	1.98e-02	0.3600	-1.10e-03	8.04e-02	-0.321000	0.142000	9.90e-01	0.35700	2.35e-04	1.04e-01
Nuclear Pore Complex (NPC) Disassembly	34	3.45e-03	2.02e-02	0.3970	2.18e-01	-3.00e-03	-0.304000	0.133000	2.82e-02	0.97600	2.18e-03	1.79e-01
RAC1 GTPase cycle	109	3.51e-03	2.05e-02	0.2220	-1.08e-02	-1.66e-02	0.218000	-0.036300	8.46e-01	0.76600	8.61e-05	5.15e-01
Toll-like Receptor Cascades	108	3.57e-03	2.07e-02	0.2190	9.90e-03	3.21e-02	0.213000	0.037500	8.59e-01	0.56600	1.40e-04	5.02e-01
SUMOylation of DNA damage response and repair proteins	67	3.58e-03	2.07e-02	0.2860	1.55e-01	6.09e-02	-0.199000	0.121000	2.89e-02	0.38900	4.95e-03	8.87e-02
SARS-CoV Infections	115	3.60e-03	2.07e-02	0.2000	-4.27e-02	-1.10e-02	0.093400	0.172000	4.31e-01	0.84000	8.46e-02	1.52e-03
MAPK6/MAPK4 signaling	66	3.68e-03	2.10e-02	0.2670	8.23e-02	1.30e-02	0.161000	0.196000	2.48e-01	0.85500	2.43e-02	5.95e-03
RHOC GTPase cycle	49	3.70e-03	2.11e-02	0.3290	-1.83e-02	1.27e-01	0.255000	0.163000	8.25e-01	0.12500	2.08e-03	4.81e-02
Regulation of ornithine decarboxylase (ODC)	43	3.76e-03	2.13e-02	0.3270	8.31e-02	-3.00e-03	0.220000	0.227000	3.47e-01	0.97300	1.27e-02	1.02e-02
RHO GTPases activate PKNs	24	3.87e-03	2.18e-02	0.4580	1.82e-01	9.29e-02	0.394000	0.112000	1.22e-01	0.43100	8.29e-04	3.43e-01
SUMOylation of ubiquitinylation proteins	37	3.90e-03	2.18e-02	0.3810	2.37e-01	7.22e-02	-0.196000	0.214000	1.27e-02	0.44800	3.93e-02	2.47e-02
p53-Dependent G1 DNA Damage Response	55	3.93e-03	2.18e-02	0.2850	1.01e-01	-2.35e-02	0.106000	0.244000	1.97e-01	0.76300	1.73e-01	1.80e-03
p53-Dependent G1/S DNA damage checkpoint	55	3.93e-03	2.18e-02	0.2850	1.01e-01	-2.35e-02	0.106000	0.244000	1.97e-01	0.76300	1.73e-01	1.80e-03
HDR through Homologous Recombination (HRR)	58	3.94e-03	2.18e-02	0.2990	2.33e-01	-6.46e-03	-0.180000	0.051200	2.22e-03	0.93200	1.80e-02	5.01e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	155	4.02e-03	2.21e-02	0.1840	4.15e-02	4.17e-02	0.174000	-0.005480	3.75e-01	0.37300	2.00e-04	9.07e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	433	4.08e-03	2.23e-02	0.1060	3.47e-02	-2.39e-02	0.090700	0.033700	2.22e-01	0.40100	1.41e-03	2.35e-01
Telomere Maintenance	55	4.12e-03	2.24e-02	0.3210	-4.99e-02	7.61e-02	-0.269000	0.151000	5.22e-01	0.33000	5.76e-04	5.31e-02
Negative regulation of the PI3K/AKT network	53	4.14e-03	2.24e-02	0.3210	-2.32e-01	1.00e-01	0.115000	0.161000	3.53e-03	0.20900	1.49e-01	4.30e-02
G-protein beta:gamma signalling	20	4.21e-03	2.26e-02	0.4920	-7.04e-02	2.88e-02	0.464000	0.145000	5.86e-01	0.82400	3.28e-04	2.61e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	42	4.22e-03	2.26e-02	0.3180	6.25e-02	-6.85e-02	0.208000	0.221000	4.84e-01	0.44300	1.97e-02	1.33e-02
RHO GTPase cycle	281	4.27e-03	2.26e-02	0.1300	8.82e-03	-1.70e-02	0.123000	0.039300	8.01e-01	0.62600	4.41e-04	2.61e-01
Regulation of lipid metabolism by PPARalpha	81	4.27e-03	2.26e-02	0.2490	8.21e-02	2.14e-02	0.232000	0.030400	2.03e-01	0.73900	3.19e-04	6.37e-01
Regulation of Apoptosis	45	4.30e-03	2.26e-02	0.3120	1.04e-01	-3.49e-02	0.188000	0.222000	2.27e-01	0.68600	2.90e-02	9.94e-03
CDT1 association with the CDC6:ORC:origin complex	50	4.31e-03	2.26e-02	0.2900	1.31e-01	-8.24e-02	0.103000	0.223000	1.11e-01	0.31400	2.10e-01	6.46e-03
Heparan sulfate/heparin (HS-GAG) metabolism	19	4.34e-03	2.26e-02	0.5440	-3.72e-01	3.54e-01	0.106000	0.146000	5.05e-03	0.00758	4.24e-01	2.71e-01
Hedgehog ‘on’ state	61	4.38e-03	2.26e-02	0.2630	6.69e-02	-6.06e-02	0.176000	0.174000	3.67e-01	0.41400	1.79e-02	1.87e-02
Plasma lipoprotein assembly, remodeling, and clearance	32	4.38e-03	2.26e-02	0.4000	-2.04e-01	1.08e-01	0.317000	0.080400	4.59e-02	0.29000	1.94e-03	4.31e-01
Response to elevated platelet cytosolic Ca2+	53	4.38e-03	2.26e-02	0.3110	-1.55e-01	5.26e-02	0.263000	-0.024700	5.14e-02	0.50800	9.37e-04	7.56e-01
Growth hormone receptor signaling	17	4.39e-03	2.26e-02	0.5140	-7.45e-02	-1.71e-02	0.398000	0.316000	5.95e-01	0.90300	4.47e-03	2.42e-02
Transferrin endocytosis and recycling	19	4.39e-03	2.26e-02	0.5200	8.64e-02	1.32e-01	0.470000	-0.155000	5.15e-01	0.32100	3.87e-04	2.43e-01
RAC2 GTPase cycle	58	4.48e-03	2.28e-02	0.2980	-3.62e-02	5.65e-02	0.283000	-0.066400	6.34e-01	0.45800	1.98e-04	3.83e-01
Signaling by Rho GTPases	421	4.50e-03	2.28e-02	0.1060	3.88e-02	-1.98e-02	0.090600	0.035000	1.78e-01	0.49100	1.64e-03	2.24e-01
Degradation of GLI1 by the proteasome	51	4.51e-03	2.28e-02	0.2880	8.11e-02	-5.90e-02	0.184000	0.198000	3.17e-01	0.46700	2.36e-02	1.46e-02
Detoxification of Reactive Oxygen Species	23	4.61e-03	2.33e-02	0.4750	-8.75e-02	1.66e-02	0.444000	-0.143000	4.68e-01	0.89100	2.28e-04	2.35e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	10	4.64e-03	2.33e-02	0.7350	2.18e-03	-4.79e-02	0.623000	-0.387000	9.90e-01	0.79300	6.45e-04	3.43e-02
RHO GTPases Activate WASPs and WAVEs	29	4.65e-03	2.33e-02	0.4190	1.33e-02	7.47e-02	0.407000	-0.065000	9.01e-01	0.48700	1.48e-04	5.45e-01
Vif-mediated degradation of APOBEC3G	43	4.69e-03	2.34e-02	0.3150	7.46e-02	-4.01e-02	0.195000	0.232000	3.98e-01	0.64900	2.73e-02	8.42e-03
RNA polymerase II transcribes snRNA genes	63	4.76e-03	2.36e-02	0.2670	2.06e-01	-7.36e-02	0.087900	0.126000	4.73e-03	0.31300	2.29e-01	8.47e-02
TNFR2 non-canonical NF-kB pathway	67	4.82e-03	2.38e-02	0.2420	6.18e-02	-1.13e-01	0.098400	0.179000	3.83e-01	0.11000	1.65e-01	1.14e-02
Mitochondrial translation elongation	83	5.12e-03	2.51e-02	0.2470	-9.96e-05	-1.09e-01	-0.208000	-0.078200	9.99e-01	0.08820	1.08e-03	2.19e-01
Telomere C-strand (Lagging Strand) Synthesis	29	5.14e-03	2.51e-02	0.4270	2.07e-02	6.38e-02	-0.387000	0.167000	8.47e-01	0.55300	3.11e-04	1.19e-01
Antigen processing-Cross presentation	77	5.14e-03	2.51e-02	0.2460	6.58e-02	-5.44e-02	0.226000	0.043300	3.19e-01	0.41100	6.13e-04	5.12e-01
Transcriptional regulation by RUNX2	82	5.17e-03	2.51e-02	0.2250	4.53e-02	-4.10e-02	0.149000	0.157000	4.79e-01	0.52200	1.97e-02	1.40e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF)	46	5.18e-03	2.51e-02	0.3150	1.06e-01	1.34e-01	0.180000	-0.195000	2.15e-01	0.11600	3.46e-02	2.26e-02
Transcriptional regulation by RUNX3	75	5.86e-03	2.82e-02	0.2350	6.34e-03	-2.69e-02	0.149000	0.180000	9.25e-01	0.68800	2.64e-02	7.28e-03
Toll Like Receptor 4 (TLR4) Cascade	93	5.89e-03	2.83e-02	0.2250	3.02e-03	-1.65e-03	0.223000	0.028300	9.60e-01	0.97800	2.03e-04	6.38e-01
SUMOylation	136	5.93e-03	2.83e-02	0.1990	4.83e-02	4.93e-02	-0.144000	0.119000	3.33e-01	0.32300	3.84e-03	1.70e-02
DNA Replication Pre-Initiation	72	6.14e-03	2.92e-02	0.2520	1.33e-01	-2.14e-02	-0.063400	0.203000	5.08e-02	0.75400	3.53e-01	2.92e-03
Phospholipid metabolism	129	6.16e-03	2.92e-02	0.1950	-4.51e-02	6.36e-02	0.169000	-0.055400	3.78e-01	0.21400	9.33e-04	2.79e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	44	6.33e-03	2.96e-02	0.3000	6.29e-02	-6.36e-02	0.176000	0.226000	4.71e-01	0.46600	4.42e-02	9.51e-03
p53-Independent DNA Damage Response	44	6.33e-03	2.96e-02	0.3000	6.29e-02	-6.36e-02	0.176000	0.226000	4.71e-01	0.46600	4.42e-02	9.51e-03
p53-Independent G1/S DNA damage checkpoint	44	6.33e-03	2.96e-02	0.3000	6.29e-02	-6.36e-02	0.176000	0.226000	4.71e-01	0.46600	4.42e-02	9.51e-03
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	46	6.43e-03	3.00e-02	0.2960	1.03e-01	-5.34e-02	0.176000	0.208000	2.28e-01	0.53100	3.97e-02	1.46e-02
HIV Infection	188	6.53e-03	3.03e-02	0.1630	6.15e-02	4.33e-02	0.007580	0.144000	1.48e-01	0.30900	8.59e-01	6.97e-04
Interleukin-4 and Interleukin-13 signaling	48	6.81e-03	3.15e-02	0.3050	-1.12e-01	1.83e-03	0.053900	0.278000	1.81e-01	0.98300	5.19e-01	8.66e-04
Insulin receptor recycling	17	6.86e-03	3.16e-02	0.5300	8.05e-02	1.12e-01	0.509000	-0.049000	5.66e-01	0.42200	2.82e-04	7.26e-01
Phosphorylation of CD3 and TCR zeta chains	10	6.91e-03	3.17e-02	0.6290	-4.76e-02	-2.62e-01	-0.140000	0.552000	7.95e-01	0.15200	4.44e-01	2.49e-03
Regulation of IFNG signaling	13	7.10e-03	3.25e-02	0.5840	3.17e-01	5.67e-02	0.423000	0.241000	4.78e-02	0.72400	8.24e-03	1.33e-01
Collagen formation	27	7.16e-03	3.26e-02	0.4120	-2.33e-01	1.07e-01	0.248000	-0.207000	3.66e-02	0.33500	2.61e-02	6.35e-02
Cyclin A/B1/B2 associated events during G2/M transition	21	7.29e-03	3.30e-02	0.4670	4.29e-01	-9.80e-02	-0.091800	0.126000	6.70e-04	0.43700	4.67e-01	3.19e-01
Hedgehog ligand biogenesis	51	7.42e-03	3.35e-02	0.2860	7.79e-02	-3.88e-03	0.220000	0.166000	3.36e-01	0.96200	6.62e-03	4.09e-02
Defective CFTR causes cystic fibrosis	52	7.47e-03	3.36e-02	0.2790	5.27e-02	-3.12e-02	0.214000	0.168000	5.11e-01	0.69700	7.66e-03	3.64e-02
Regulation of TP53 Activity through Phosphorylation	76	7.58e-03	3.40e-02	0.2480	2.17e-01	1.27e-02	-0.092300	0.075800	1.13e-03	0.84800	1.65e-01	2.54e-01
SARS-CoV-2 Infection	56	7.71e-03	3.44e-02	0.2720	-1.13e-01	-1.53e-02	0.128000	0.212000	1.43e-01	0.84400	9.82e-02	6.25e-03
ER-Phagosome pathway	69	7.91e-03	3.48e-02	0.2430	7.21e-02	-7.08e-02	0.202000	0.089000	3.01e-01	0.31100	3.75e-03	2.02e-01
G1/S DNA Damage Checkpoints	57	7.92e-03	3.48e-02	0.2660	1.03e-01	-2.03e-02	0.089000	0.228000	1.78e-01	0.79100	2.46e-01	2.99e-03
ROS and RNS production in phagocytes	23	7.94e-03	3.48e-02	0.4550	-4.31e-02	-3.68e-03	0.437000	-0.121000	7.21e-01	0.97600	2.89e-04	3.14e-01
Metabolism of steroids	81	7.94e-03	3.48e-02	0.2400	1.16e-01	6.11e-02	0.186000	-0.077900	7.25e-02	0.34300	3.97e-03	2.27e-01
Activated NOTCH1 Transmits Signal to the Nucleus	19	7.95e-03	3.48e-02	0.4680	-1.86e-01	-1.11e-01	0.394000	0.129000	1.60e-01	0.40200	2.98e-03	3.32e-01
TBC/RABGAPs	38	8.15e-03	3.56e-02	0.3490	-1.41e-01	1.01e-01	0.281000	0.114000	1.32e-01	0.28200	2.77e-03	2.23e-01
CDK-mediated phosphorylation and removal of Cdc6	62	8.25e-03	3.57e-02	0.2500	8.74e-02	-4.15e-02	0.111000	0.202000	2.35e-01	0.57300	1.32e-01	6.01e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA	46	8.26e-03	3.57e-02	0.2850	2.22e-03	-8.60e-02	0.195000	0.189000	9.79e-01	0.31400	2.23e-02	2.70e-02
Homology Directed Repair	88	8.27e-03	3.57e-02	0.2300	1.77e-01	3.88e-02	-0.121000	0.076200	4.28e-03	0.53100	5.13e-02	2.18e-01
Synthesis of IP3 and IP4 in the cytosol	15	8.55e-03	3.68e-02	0.5470	-2.60e-01	2.33e-01	0.388000	-0.163000	8.09e-02	0.11900	9.36e-03	2.74e-01
RAB geranylgeranylation	38	8.62e-03	3.69e-02	0.3420	1.29e-01	-1.88e-01	0.255000	-0.001730	1.71e-01	0.04560	6.63e-03	9.85e-01
Ubiquitin-dependent degradation of Cyclin D	44	8.65e-03	3.69e-02	0.2940	2.11e-02	-4.67e-02	0.166000	0.237000	8.09e-01	0.59200	5.67e-02	6.62e-03
Assembly of the pre-replicative complex	59	8.71e-03	3.69e-02	0.2560	1.03e-01	-5.59e-02	0.044400	0.223000	1.73e-01	0.45900	5.56e-01	3.11e-03
Transmission across Chemical Synapses	95	8.72e-03	3.69e-02	0.2210	-1.07e-01	3.36e-02	0.169000	-0.086600	7.11e-02	0.57300	4.56e-03	1.46e-01
Constitutive Signaling by Aberrant PI3K in Cancer	26	8.81e-03	3.72e-02	0.4350	-3.07e-01	1.23e-01	0.069700	0.273000	6.78e-03	0.27700	5.39e-01	1.59e-02
Mitochondrial translation	88	8.95e-03	3.75e-02	0.2310	3.91e-02	-1.05e-01	-0.187000	-0.076000	5.27e-01	0.08960	2.44e-03	2.19e-01
Signaling by BRAF and RAF fusions	42	8.95e-03	3.75e-02	0.3180	9.80e-02	-1.73e-01	0.247000	0.025900	2.72e-01	0.05340	5.73e-03	7.72e-01
SUMOylation of SUMOylation proteins	32	9.03e-03	3.77e-02	0.3850	1.75e-01	5.78e-02	-0.294000	0.167000	8.74e-02	0.57200	4.08e-03	1.02e-01
Platelet degranulation	49	9.06e-03	3.77e-02	0.3050	-1.56e-01	2.51e-02	0.258000	-0.040400	5.95e-02	0.76200	1.82e-03	6.25e-01
Transcriptional regulation by small RNAs	43	9.13e-03	3.79e-02	0.3320	8.60e-02	9.98e-03	-0.228000	0.225000	3.30e-01	0.91000	9.66e-03	1.06e-02
RHO GTPases activate CIT	14	9.24e-03	3.81e-02	0.5260	1.85e-01	-1.96e-01	0.404000	0.203000	2.31e-01	0.20500	8.91e-03	1.88e-01
COPI-independent Golgi-to-ER retrograde traffic	28	9.29e-03	3.81e-02	0.3970	9.25e-02	-3.07e-02	0.385000	0.015100	3.97e-01	0.77900	4.31e-04	8.90e-01
Hh mutants are degraded by ERAD	47	9.29e-03	3.81e-02	0.2880	7.57e-02	-4.24e-02	0.227000	0.156000	3.70e-01	0.61500	7.27e-03	6.46e-02
Degradation of beta-catenin by the destruction complex	68	9.31e-03	3.81e-02	0.2470	5.38e-02	3.01e-02	0.154000	0.183000	4.44e-01	0.66800	2.83e-02	9.04e-03
Mitochondrial translation initiation	83	9.41e-03	3.83e-02	0.2360	2.33e-02	-9.94e-02	-0.194000	-0.086500	7.15e-01	0.11800	2.28e-03	1.74e-01
Sphingolipid metabolism	50	9.45e-03	3.83e-02	0.2950	-1.17e-02	1.64e-01	0.229000	-0.086800	8.86e-01	0.04530	5.17e-03	2.89e-01
G1/S-Specific Transcription	25	9.51e-03	3.83e-02	0.4240	2.24e-01	-1.14e-01	-0.326000	0.103000	5.25e-02	0.32300	4.87e-03	3.73e-01
SUMO E3 ligases SUMOylate target proteins	130	9.52e-03	3.83e-02	0.1990	2.87e-02	6.19e-02	-0.134000	0.130000	5.74e-01	0.22500	8.57e-03	1.08e-02
EPH-ephrin mediated repulsion of cells	25	9.53e-03	3.83e-02	0.4120	-1.95e-01	-1.23e-02	0.348000	0.102000	9.14e-02	0.91500	2.62e-03	3.78e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	82	9.59e-03	3.84e-02	0.2350	1.93e-01	5.59e-02	-0.096600	0.073700	2.56e-03	0.38300	1.31e-01	2.50e-01
Mitochondrial translation termination	82	9.65e-03	3.84e-02	0.2370	1.94e-02	-1.03e-01	-0.197000	-0.078500	7.63e-01	0.10800	2.05e-03	2.20e-01
Autodegradation of the E3 ubiquitin ligase COP1	43	9.65e-03	3.84e-02	0.2900	3.56e-02	-7.63e-02	0.155000	0.230000	6.87e-01	0.38700	7.85e-02	9.13e-03
Neurotransmitter receptors and postsynaptic signal transmission	73	9.73e-03	3.85e-02	0.2490	-1.19e-01	4.18e-02	0.209000	-0.050800	8.02e-02	0.53800	2.06e-03	4.54e-01
Regulation of HMOX1 expression and activity	55	1.01e-02	3.98e-02	0.2650	8.09e-02	-3.34e-02	0.198000	0.152000	3.00e-01	0.66900	1.10e-02	5.10e-02
Glycerophospholipid biosynthesis	71	1.02e-02	4.01e-02	0.2490	-3.57e-02	1.10e-01	0.208000	-0.073000	6.04e-01	0.10900	2.53e-03	2.89e-01
Pre-NOTCH Expression and Processing	41	1.05e-02	4.11e-02	0.3300	-9.47e-02	1.03e-01	0.226000	0.195000	2.95e-01	0.25500	1.25e-02	3.05e-02
Amino acids regulate mTORC1	43	1.06e-02	4.12e-02	0.3210	-7.00e-04	1.09e-01	0.296000	0.061100	9.94e-01	0.21900	8.08e-04	4.89e-01
Signaling by NOTCH1	50	1.06e-02	4.14e-02	0.2870	-6.34e-02	1.44e-02	0.250000	0.124000	4.39e-01	0.86100	2.23e-03	1.30e-01
G beta:gamma signalling through PI3Kgamma	16	1.08e-02	4.19e-02	0.4890	-1.24e-01	-5.46e-02	0.374000	0.284000	3.91e-01	0.70600	9.63e-03	4.92e-02
Apoptosis	132	1.09e-02	4.22e-02	0.1740	6.74e-02	-4.57e-02	0.146000	0.049700	1.83e-01	0.36700	3.99e-03	3.26e-01
Inositol phosphate metabolism	29	1.09e-02	4.22e-02	0.3900	-1.11e-01	9.76e-02	0.332000	-0.142000	3.02e-01	0.36300	2.00e-03	1.88e-01
Cytoprotection by HMOX1	94	1.11e-02	4.27e-02	0.2000	2.19e-02	-7.91e-02	0.169000	0.069500	7.14e-01	0.18600	4.74e-03	2.46e-01
Switching of origins to a post-replicative state	79	1.13e-02	4.34e-02	0.2240	1.28e-01	-3.06e-02	-0.017600	0.181000	5.03e-02	0.63900	7.87e-01	5.58e-03
Degradation of GLI2 by the proteasome	50	1.22e-02	4.61e-02	0.2660	6.57e-02	-6.82e-02	0.161000	0.188000	4.22e-01	0.40500	4.87e-02	2.14e-02
GLI3 is processed to GLI3R by the proteasome	50	1.22e-02	4.61e-02	0.2660	6.57e-02	-6.82e-02	0.161000	0.188000	4.22e-01	0.40500	4.87e-02	2.14e-02
MAPK family signaling cascades	184	1.22e-02	4.61e-02	0.1500	-4.36e-03	2.89e-02	0.096500	0.111000	9.19e-01	0.50100	2.47e-02	9.59e-03
Deposition of new CENPA-containing nucleosomes at the centromere	20	1.22e-02	4.61e-02	0.4620	2.90e-01	-1.22e-02	-0.358000	0.035000	2.48e-02	0.92500	5.61e-03	7.86e-01
Nucleosome assembly	20	1.22e-02	4.61e-02	0.4620	2.90e-01	-1.22e-02	-0.358000	0.035000	2.48e-02	0.92500	5.61e-03	7.86e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	64	1.23e-02	4.64e-02	0.2390	9.70e-02	-4.03e-02	0.144000	0.160000	1.80e-01	0.57800	4.75e-02	2.74e-02
RHOH GTPase cycle	28	1.24e-02	4.66e-02	0.3540	8.96e-02	-2.52e-01	0.191000	0.131000	4.12e-01	0.02090	8.12e-02	2.31e-01
Uptake and function of anthrax toxins	10	1.37e-02	5.13e-02	0.5970	-1.67e-01	-1.56e-01	0.463000	0.299000	3.62e-01	0.39500	1.12e-02	1.01e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	20	1.45e-02	5.41e-02	0.4630	5.81e-02	-4.57e-02	-0.407000	0.210000	6.53e-01	0.72400	1.66e-03	1.04e-01
Deubiquitination	192	1.47e-02	5.43e-02	0.1400	9.62e-02	-3.34e-02	0.072900	0.062600	2.23e-02	0.42800	8.32e-02	1.37e-01
Class I MHC mediated antigen processing & presentation	282	1.47e-02	5.45e-02	0.1210	9.23e-02	5.29e-03	0.074900	0.023000	8.19e-03	0.88000	3.20e-02	5.10e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	30	1.48e-02	5.45e-02	0.3690	-1.36e-01	8.74e-02	0.284000	0.173000	1.97e-01	0.40800	7.20e-03	1.02e-01
Diseases of carbohydrate metabolism	22	1.48e-02	5.45e-02	0.4360	-2.54e-01	3.01e-02	0.318000	-0.154000	3.91e-02	0.80700	9.86e-03	2.11e-01
BBSome-mediated cargo-targeting to cilium	19	1.53e-02	5.62e-02	0.4620	1.71e-01	-1.06e-01	-0.357000	-0.213000	1.97e-01	0.42300	7.05e-03	1.09e-01
RHO GTPases Activate NADPH Oxidases	14	1.59e-02	5.79e-02	0.5360	-3.42e-01	5.11e-02	0.397000	0.098600	2.66e-02	0.74100	1.02e-02	5.23e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	27	1.60e-02	5.83e-02	0.3670	-5.91e-02	-5.50e-02	0.329000	0.142000	5.95e-01	0.62100	3.15e-03	2.01e-01
Arachidonic acid metabolism	20	1.64e-02	5.94e-02	0.4600	-9.21e-02	-6.93e-03	0.290000	-0.346000	4.76e-01	0.95700	2.50e-02	7.47e-03
RHO GTPases activate PAKs	13	1.67e-02	6.03e-02	0.5510	2.12e-01	-8.82e-02	0.500000	0.028400	1.86e-01	0.58200	1.81e-03	8.60e-01
Orc1 removal from chromatin	61	1.68e-02	6.05e-02	0.2450	1.27e-01	-3.21e-02	-0.015600	0.207000	8.68e-02	0.66600	8.33e-01	5.34e-03
Asymmetric localization of PCP proteins	51	1.70e-02	6.11e-02	0.2650	-3.22e-02	-4.11e-03	0.135000	0.226000	6.92e-01	0.96000	9.70e-02	5.40e-03
Autodegradation of Cdh1 by Cdh1:APC/C	56	1.70e-02	6.11e-02	0.2400	4.89e-02	-8.69e-02	0.140000	0.167000	5.28e-01	0.26100	7.06e-02	3.04e-02
SUMOylation of RNA binding proteins	42	1.71e-02	6.12e-02	0.3130	1.22e-01	2.14e-02	-0.276000	0.081800	1.72e-01	0.81000	1.99e-03	3.60e-01
Regulation of RAS by GAPs	56	1.72e-02	6.12e-02	0.2530	6.95e-02	3.53e-03	0.169000	0.176000	3.69e-01	0.96400	2.92e-02	2.33e-02
Interferon gamma signaling	55	1.72e-02	6.12e-02	0.2690	2.21e-01	6.08e-02	0.135000	0.032900	4.56e-03	0.43600	8.27e-02	6.74e-01
Collagen biosynthesis and modifying enzymes	17	1.74e-02	6.17e-02	0.4960	-2.77e-01	-7.93e-02	0.251000	-0.317000	4.83e-02	0.57200	7.35e-02	2.36e-02
Cilium Assembly	147	1.76e-02	6.23e-02	0.1660	1.46e-01	1.93e-02	-0.067100	0.034500	2.34e-03	0.68700	1.62e-01	4.72e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	29	1.80e-02	6.28e-02	0.3540	1.32e-02	-7.65e-02	0.334000	0.086900	9.02e-01	0.47600	1.85e-03	4.18e-01
Signaling by RAS mutants	29	1.80e-02	6.28e-02	0.3540	1.32e-02	-7.65e-02	0.334000	0.086900	9.02e-01	0.47600	1.85e-03	4.18e-01
Signaling by moderate kinase activity BRAF mutants	29	1.80e-02	6.28e-02	0.3540	1.32e-02	-7.65e-02	0.334000	0.086900	9.02e-01	0.47600	1.85e-03	4.18e-01
Signaling downstream of RAS mutants	29	1.80e-02	6.28e-02	0.3540	1.32e-02	-7.65e-02	0.334000	0.086900	9.02e-01	0.47600	1.85e-03	4.18e-01
FLT3 Signaling	33	1.81e-02	6.28e-02	0.3400	-2.44e-01	8.19e-04	0.117000	0.205000	1.53e-02	0.99400	2.44e-01	4.17e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	10	1.82e-02	6.28e-02	0.6180	1.26e-01	-1.27e-01	-0.337000	0.486000	4.90e-01	0.48700	6.53e-02	7.83e-03
Oncogenic MAPK signaling	56	1.82e-02	6.28e-02	0.2660	1.18e-01	-6.96e-02	0.228000	-0.002230	1.28e-01	0.36800	3.27e-03	9.77e-01
Death Receptor Signalling	96	1.82e-02	6.28e-02	0.1910	-1.36e-02	-5.57e-02	0.170000	0.065800	8.19e-01	0.34700	4.14e-03	2.67e-01
Diseases associated with glycosaminoglycan metabolism	15	1.84e-02	6.33e-02	0.5590	-2.98e-01	4.04e-01	0.013000	0.245000	4.59e-02	0.00681	9.31e-01	1.00e-01
Mitochondrial tRNA aminoacylation	18	1.86e-02	6.37e-02	0.4850	8.89e-02	-3.04e-01	-0.331000	-0.158000	5.14e-01	0.02540	1.52e-02	2.45e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	47	1.91e-02	6.53e-02	0.2940	-2.12e-01	7.16e-02	0.140000	0.129000	1.20e-02	0.39600	9.75e-02	1.25e-01
Integration of energy metabolism	58	1.92e-02	6.53e-02	0.2630	-9.62e-02	4.10e-02	0.219000	-0.101000	2.06e-01	0.59000	3.95e-03	1.83e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	26	1.95e-02	6.59e-02	0.3880	3.54e-01	-1.09e-01	-0.105000	0.050100	1.79e-03	0.33800	3.56e-01	6.58e-01
APC/C:Cdc20 mediated degradation of Securin	58	1.95e-02	6.59e-02	0.2370	8.19e-02	-6.09e-02	0.131000	0.168000	2.82e-01	0.42300	8.44e-02	2.69e-02
RHOA GTPase cycle	91	1.96e-02	6.62e-02	0.2040	-7.16e-02	3.57e-03	0.185000	0.044800	2.39e-01	0.95300	2.30e-03	4.62e-01
Gluconeogenesis	24	1.98e-02	6.66e-02	0.4060	-2.13e-01	3.75e-02	0.331000	-0.094200	7.13e-02	0.75100	5.07e-03	4.25e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	45	1.99e-02	6.67e-02	0.2990	2.29e-01	-1.44e-02	0.187000	-0.041800	8.08e-03	0.86700	3.01e-02	6.28e-01
Hh mutants abrogate ligand secretion	48	2.01e-02	6.73e-02	0.2670	7.94e-02	-2.82e-02	0.210000	0.143000	3.42e-01	0.73600	1.20e-02	8.72e-02
G alpha (i) signalling events	87	2.03e-02	6.78e-02	0.2150	-2.10e-02	2.50e-02	0.197000	-0.080000	7.36e-01	0.68700	1.50e-03	1.99e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	56	2.04e-02	6.78e-02	0.2410	6.83e-02	-5.34e-02	0.164000	0.155000	3.78e-01	0.49000	3.43e-02	4.54e-02
The role of GTSE1 in G2/M progression after G2 checkpoint	52	2.18e-02	7.25e-02	0.2500	1.19e-01	-5.48e-02	0.129000	0.169000	1.37e-01	0.49500	1.07e-01	3.56e-02
tRNA Aminoacylation	23	2.23e-02	7.35e-02	0.4170	9.27e-02	-2.26e-01	-0.319000	-0.111000	4.42e-01	0.06110	8.09e-03	3.55e-01
G alpha (q) signalling events	72	2.23e-02	7.35e-02	0.2330	-1.48e-01	6.46e-02	0.167000	0.013300	3.08e-02	0.34400	1.43e-02	8.46e-01
Signalling to ERKs	26	2.24e-02	7.36e-02	0.3550	4.62e-02	-1.08e-01	0.301000	0.147000	6.84e-01	0.34100	7.96e-03	1.95e-01
Plasma lipoprotein clearance	19	2.25e-02	7.36e-02	0.4440	-2.39e-01	5.83e-02	0.358000	0.093700	7.13e-02	0.66000	6.93e-03	4.80e-01
Nuclear Events (kinase and transcription factor activation)	43	2.25e-02	7.36e-02	0.2980	-2.03e-01	1.90e-02	0.217000	-0.014900	2.17e-02	0.83000	1.40e-02	8.66e-01
Deadenylation of mRNA	21	2.26e-02	7.36e-02	0.4160	2.59e-01	-5.63e-02	-0.146000	0.286000	4.03e-02	0.65500	2.48e-01	2.35e-02
Regulation of TP53 Activity	131	2.26e-02	7.36e-02	0.1740	7.56e-02	-6.50e-03	-0.127000	0.091800	1.37e-01	0.89800	1.27e-02	7.09e-02
RHOB GTPase cycle	44	2.29e-02	7.42e-02	0.2980	-1.13e-02	1.41e-01	0.245000	0.094800	8.97e-01	0.10700	4.98e-03	2.77e-01
SUMOylation of chromatin organization proteins	49	2.30e-02	7.43e-02	0.2880	8.87e-02	9.85e-02	-0.229000	0.112000	2.84e-01	0.23400	5.56e-03	1.74e-01
Nuclear Envelope Breakdown	49	2.34e-02	7.55e-02	0.2840	1.45e-01	2.91e-02	-0.193000	0.146000	7.89e-02	0.72500	1.95e-02	7.73e-02
RHOQ GTPase cycle	39	2.35e-02	7.55e-02	0.3060	5.84e-02	1.19e-01	0.231000	-0.152000	5.29e-01	0.20000	1.27e-02	1.01e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	32	2.36e-02	7.57e-02	0.3160	-1.88e-01	-1.95e-01	-0.053000	0.155000	6.63e-02	0.05610	6.04e-01	1.30e-01
SCF(Skp2)-mediated degradation of p27/p21	52	2.38e-02	7.61e-02	0.2490	9.71e-02	-3.28e-02	0.088200	0.209000	2.27e-01	0.68300	2.72e-01	9.12e-03
Regulation of TP53 Activity through Acetylation	26	2.39e-02	7.62e-02	0.3940	-2.54e-01	2.70e-02	-0.166000	0.249000	2.50e-02	0.81200	1.42e-01	2.80e-02
CDC6 association with the ORC:origin complex	10	2.41e-02	7.66e-02	0.6080	5.42e-01	-1.76e-01	-0.170000	0.128000	3.02e-03	0.33400	3.52e-01	4.85e-01
COPI-dependent Golgi-to-ER retrograde traffic	64	2.46e-02	7.81e-02	0.2400	1.24e-01	1.36e-01	0.153000	-0.000170	8.65e-02	0.05990	3.41e-02	9.98e-01
NOD1/2 Signaling Pathway	23	2.51e-02	7.95e-02	0.3700	2.33e-01	-1.85e-01	0.106000	0.193000	5.33e-02	0.12500	3.81e-01	1.10e-01
Vpu mediated degradation of CD4	44	2.55e-02	8.05e-02	0.2620	4.99e-02	-6.95e-02	0.150000	0.197000	5.67e-01	0.42600	8.48e-02	2.41e-02
Base Excision Repair	36	2.62e-02	8.25e-02	0.3260	-2.82e-02	-4.45e-02	-0.283000	0.152000	7.70e-01	0.64400	3.29e-03	1.16e-01
Positive epigenetic regulation of rRNA expression	37	2.67e-02	8.39e-02	0.3290	1.88e-02	3.14e-02	-0.237000	0.225000	8.44e-01	0.74200	1.28e-02	1.80e-02
HCMV Early Events	50	2.68e-02	8.40e-02	0.2750	1.27e-01	-1.11e-02	-0.217000	0.110000	1.20e-01	0.89200	8.14e-03	1.78e-01
HIV Life Cycle	127	2.71e-02	8.44e-02	0.1770	7.29e-02	4.29e-02	-0.067600	0.140000	1.58e-01	0.40600	1.90e-01	6.61e-03
Sealing of the nuclear envelope (NE) by ESCRT-III	19	2.72e-02	8.44e-02	0.4210	-7.40e-02	1.66e-03	0.370000	0.185000	5.77e-01	0.99000	5.22e-03	1.62e-01
Viral Messenger RNA Synthesis	40	2.72e-02	8.44e-02	0.3140	7.13e-02	3.83e-02	-0.242000	0.183000	4.36e-01	0.67500	8.07e-03	4.56e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	63	2.74e-02	8.47e-02	0.2200	1.17e-01	-7.81e-02	0.070900	0.153000	1.08e-01	0.28500	3.32e-01	3.65e-02
Resolution of Abasic Sites (AP sites)	30	2.86e-02	8.83e-02	0.3500	-4.07e-02	-8.72e-02	-0.304000	0.143000	7.00e-01	0.40900	3.96e-03	1.76e-01
Recycling pathway of L1	16	2.87e-02	8.83e-02	0.4760	-1.42e-01	1.85e-02	0.452000	-0.044700	3.27e-01	0.89800	1.74e-03	7.57e-01
NIK–>noncanonical NF-kB signaling	51	3.01e-02	9.22e-02	0.2390	5.24e-02	-8.47e-02	0.158000	0.149000	5.18e-01	0.29600	5.19e-02	6.55e-02
Golgi Cisternae Pericentriolar Stack Reorganization	14	3.01e-02	9.22e-02	0.5180	1.91e-01	-3.13e-01	0.352000	-0.101000	2.15e-01	0.04260	2.26e-02	5.13e-01
Other semaphorin interactions	10	3.05e-02	9.33e-02	0.6400	-7.13e-02	-2.55e-01	0.430000	-0.393000	6.97e-01	0.16300	1.85e-02	3.16e-02
APC/C:Cdc20 mediated degradation of mitotic proteins	65	3.09e-02	9.37e-02	0.2160	1.33e-01	-7.32e-02	0.068300	0.137000	6.51e-02	0.30900	3.42e-01	5.57e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	23	3.09e-02	9.37e-02	0.3920	3.81e-01	-1.60e-02	-0.087700	0.027300	1.56e-03	0.89400	4.67e-01	8.21e-01
NRAGE signals death through JNK	31	3.11e-02	9.37e-02	0.3450	-1.58e-01	1.55e-01	0.258000	0.054300	1.28e-01	0.13500	1.29e-02	6.01e-01
MAPK1/MAPK3 signaling	160	3.11e-02	9.37e-02	0.1440	-2.23e-02	1.20e-02	0.092800	0.107000	6.29e-01	0.79500	4.38e-02	2.02e-02
Nonhomologous End-Joining (NHEJ)	28	3.12e-02	9.37e-02	0.3530	3.24e-01	1.08e-01	-0.069300	0.055800	3.04e-03	0.32200	5.26e-01	6.10e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	71	3.14e-02	9.37e-02	0.2270	-3.54e-02	-1.68e-02	0.218000	-0.046400	6.07e-01	0.80700	1.50e-03	5.00e-01
Toll Like Receptor 2 (TLR2) Cascade	71	3.14e-02	9.37e-02	0.2270	-3.54e-02	-1.68e-02	0.218000	-0.046400	6.07e-01	0.80700	1.50e-03	5.00e-01
Toll Like Receptor TLR1:TLR2 Cascade	71	3.14e-02	9.37e-02	0.2270	-3.54e-02	-1.68e-02	0.218000	-0.046400	6.07e-01	0.80700	1.50e-03	5.00e-01
Toll Like Receptor TLR6:TLR2 Cascade	71	3.14e-02	9.37e-02	0.2270	-3.54e-02	-1.68e-02	0.218000	-0.046400	6.07e-01	0.80700	1.50e-03	5.00e-01
Unwinding of DNA	10	3.16e-02	9.40e-02	0.6030	-2.98e-02	1.03e-01	-0.582000	0.112000	8.70e-01	0.57200	1.43e-03	5.41e-01
Nuclear Receptor transcription pathway	25	3.17e-02	9.40e-02	0.3850	-3.47e-01	4.20e-02	-0.110000	0.118000	2.70e-03	0.71600	3.39e-01	3.07e-01
G beta:gamma signalling through CDC42	12	3.19e-02	9.40e-02	0.5370	1.96e-01	1.62e-01	0.352000	0.314000	2.39e-01	0.33100	3.46e-02	5.93e-02
Transcriptional Regulation by E2F6	29	3.20e-02	9.40e-02	0.3560	2.42e-01	-1.56e-01	-0.205000	-0.045400	2.42e-02	0.14600	5.65e-02	6.72e-01
G-protein mediated events	32	3.20e-02	9.40e-02	0.3280	-1.24e-01	1.59e-01	0.235000	-0.107000	2.24e-01	0.12000	2.15e-02	2.94e-01
Insulin processing	17	3.21e-02	9.40e-02	0.4470	3.78e-01	4.82e-02	0.106000	0.208000	6.95e-03	0.73100	4.49e-01	1.38e-01
SUMOylation of intracellular receptors	18	3.21e-02	9.40e-02	0.4790	-8.13e-02	3.63e-01	0.152000	0.260000	5.50e-01	0.00765	2.65e-01	5.65e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	66	3.21e-02	9.40e-02	0.2130	1.28e-01	-6.92e-02	0.071200	0.138000	7.33e-02	0.33200	3.18e-01	5.25e-02
Degradation of AXIN	47	3.24e-02	9.44e-02	0.2500	6.01e-02	-4.44e-02	0.145000	0.190000	4.77e-01	0.59900	8.66e-02	2.44e-02
Regulation of FZD by ubiquitination	11	3.27e-02	9.52e-02	0.5550	-4.23e-01	2.61e-01	-0.239000	-0.062500	1.52e-02	0.13300	1.71e-01	7.20e-01
PCNA-Dependent Long Patch Base Excision Repair	18	3.30e-02	9.58e-02	0.4580	4.26e-02	3.38e-02	-0.373000	0.259000	7.54e-01	0.80400	6.12e-03	5.73e-02
GPVI-mediated activation cascade	24	3.36e-02	9.71e-02	0.3770	-1.03e-01	6.32e-02	0.338000	0.115000	3.81e-01	0.59300	4.21e-03	3.30e-01
Stimuli-sensing channels	39	3.36e-02	9.71e-02	0.2930	-3.41e-02	1.01e-01	0.201000	-0.184000	7.13e-01	0.27700	2.98e-02	4.67e-02
Signaling by Erythropoietin	20	3.41e-02	9.81e-02	0.4200	-1.96e-01	1.23e-01	0.311000	0.162000	1.29e-01	0.34200	1.63e-02	2.11e-01
APC/C-mediated degradation of cell cycle proteins	77	3.42e-02	9.81e-02	0.2030	1.63e-01	-5.29e-02	0.021400	0.107000	1.37e-02	0.42400	7.46e-01	1.07e-01
Regulation of mitotic cell cycle	77	3.42e-02	9.81e-02	0.2030	1.63e-01	-5.29e-02	0.021400	0.107000	1.37e-02	0.42400	7.46e-01	1.07e-01
G alpha (12/13) signalling events	40	3.52e-02	1.00e-01	0.2940	-5.07e-02	9.27e-02	0.257000	0.096600	5.80e-01	0.31100	4.91e-03	2.91e-01
Chromatin modifying enzymes	150	3.52e-02	1.00e-01	0.1570	-9.49e-02	1.12e-02	-0.045400	0.116000	4.58e-02	0.81300	3.40e-01	1.46e-02
Chromatin organization	150	3.52e-02	1.00e-01	0.1570	-9.49e-02	1.12e-02	-0.045400	0.116000	4.58e-02	0.81300	3.40e-01	1.46e-02
Regulation of signaling by CBL	14	3.61e-02	1.02e-01	0.5030	-1.24e-01	1.65e-01	0.254000	0.382000	4.24e-01	0.28400	1.00e-01	1.34e-02
SLC-mediated transmembrane transport	97	3.67e-02	1.04e-01	0.1930	-1.09e-01	-4.25e-02	0.119000	-0.097000	6.39e-02	0.47100	4.30e-02	9.98e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	38	3.68e-02	1.04e-01	0.2780	1.71e-01	-1.34e-01	0.120000	0.125000	6.89e-02	0.15400	2.02e-01	1.82e-01
NGF-stimulated transcription	25	3.72e-02	1.05e-01	0.3620	-3.30e-01	-7.06e-02	0.125000	0.037400	4.32e-03	0.54100	2.80e-01	7.46e-01
O-linked glycosylation	42	3.75e-02	1.05e-01	0.2800	-1.33e-01	1.80e-02	0.090900	-0.228000	1.38e-01	0.84000	3.09e-01	1.06e-02
Dectin-1 mediated noncanonical NF-kB signaling	52	3.78e-02	1.06e-01	0.2300	3.36e-02	-7.49e-02	0.150000	0.153000	6.75e-01	0.35100	6.10e-02	5.59e-02
PLC beta mediated events	29	3.82e-02	1.07e-01	0.3330	-1.24e-01	1.84e-01	0.213000	-0.128000	2.50e-01	0.08620	4.78e-02	2.33e-01
Opioid Signalling	56	3.82e-02	1.07e-01	0.2480	-1.99e-02	9.64e-02	0.227000	0.015100	7.97e-01	0.21300	3.35e-03	8.45e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	82	3.84e-02	1.07e-01	0.1950	-1.08e-01	-3.36e-02	0.146000	0.060600	9.15e-02	0.60000	2.24e-02	3.44e-01
Formation of the beta-catenin:TCF transactivating complex	24	3.88e-02	1.08e-01	0.4080	-8.36e-02	1.83e-01	-0.028000	0.354000	4.79e-01	0.12200	8.13e-01	2.73e-03
Chondroitin sulfate/dermatan sulfate metabolism	26	3.95e-02	1.09e-01	0.3510	-2.83e-01	1.95e-01	0.000964	-0.073600	1.27e-02	0.08520	9.93e-01	5.16e-01
Generation of second messenger molecules	16	3.98e-02	1.10e-01	0.4530	-3.39e-02	-2.06e-01	-0.374000	0.146000	8.15e-01	0.15300	9.55e-03	3.11e-01
Cell death signalling via NRAGE, NRIF and NADE	46	3.99e-02	1.10e-01	0.2720	-1.30e-01	6.85e-02	0.227000	0.019200	1.27e-01	0.42200	7.71e-03	8.22e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	62	4.06e-02	1.12e-01	0.2110	1.06e-01	-7.46e-02	0.071300	0.150000	1.51e-01	0.31000	3.32e-01	4.09e-02
RNA Polymerase I Transcription Initiation	38	4.07e-02	1.12e-01	0.3120	7.15e-03	5.37e-02	-0.249000	0.179000	9.39e-01	0.56700	7.95e-03	5.62e-02
Transcriptional Regulation by TP53	295	4.11e-02	1.12e-01	0.1030	4.40e-02	-1.81e-02	-0.028400	0.087400	1.98e-01	0.59600	4.05e-01	1.05e-02
RAF/MAP kinase cascade	155	4.15e-02	1.13e-01	0.1410	-2.84e-02	1.09e-02	0.091000	0.104000	5.44e-01	0.81500	5.17e-02	2.64e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	33	4.15e-02	1.13e-01	0.3230	-6.16e-02	-2.04e-02	0.304000	-0.085700	5.40e-01	0.83900	2.51e-03	3.95e-01
Budding and maturation of HIV virion	24	4.16e-02	1.13e-01	0.3550	-8.50e-02	-3.37e-02	0.320000	0.125000	4.71e-01	0.77600	6.75e-03	2.90e-01
Sensory processing of sound by outer hair cells of the cochlea	16	4.20e-02	1.14e-01	0.4990	-2.73e-01	2.59e-01	-0.036800	0.325000	5.85e-02	0.07330	7.99e-01	2.44e-02
RHO GTPases Activate Formins	100	4.23e-02	1.14e-01	0.1830	1.54e-01	-1.43e-02	-0.094700	0.021800	8.01e-03	0.80500	1.03e-01	7.07e-01
Hyaluronan uptake and degradation	10	4.23e-02	1.14e-01	0.5680	-1.57e-01	-7.71e-02	0.540000	-0.000496	3.90e-01	0.67300	3.10e-03	9.98e-01
Muscle contraction	62	4.24e-02	1.14e-01	0.2460	-7.99e-02	-1.45e-01	0.123000	-0.135000	2.77e-01	0.04930	9.51e-02	6.70e-02
Recognition of DNA damage by PCNA-containing replication complex	26	4.28e-02	1.15e-01	0.3660	7.43e-02	2.08e-02	-0.324000	0.152000	5.12e-01	0.85400	4.32e-03	1.81e-01
Activation of NF-kappaB in B cells	57	4.32e-02	1.16e-01	0.2180	2.95e-02	-4.90e-02	0.138000	0.160000	7.01e-01	0.52300	7.30e-02	3.75e-02
Lagging Strand Synthesis	17	4.34e-02	1.16e-01	0.4430	1.49e-01	-4.69e-02	-0.404000	0.095400	2.87e-01	0.73800	3.97e-03	4.96e-01
ADP signalling through P2Y purinoceptor 12	12	4.37e-02	1.16e-01	0.5010	9.13e-02	5.62e-02	0.336000	0.355000	5.84e-01	0.73600	4.37e-02	3.31e-02
Erythropoietin activates RAS	11	4.37e-02	1.16e-01	0.5580	-7.28e-02	2.61e-01	0.404000	0.274000	6.76e-01	0.13400	2.05e-02	1.16e-01
Resolution of D-Loop Structures	27	4.40e-02	1.17e-01	0.3490	3.21e-01	-1.07e-01	-0.078700	0.032700	3.94e-03	0.33400	4.79e-01	7.69e-01
ABC transporter disorders	56	4.46e-02	1.18e-01	0.2270	1.03e-02	-1.93e-02	0.188000	0.125000	8.94e-01	0.80300	1.52e-02	1.06e-01
TP53 Regulates Metabolic Genes	72	4.54e-02	1.20e-01	0.2070	3.33e-02	-9.56e-02	0.180000	0.012800	6.26e-01	0.16200	8.55e-03	8.52e-01
Sphingolipid de novo biosynthesis	23	4.60e-02	1.21e-01	0.3530	1.15e-01	2.42e-01	0.175000	-0.151000	3.42e-01	0.04510	1.47e-01	2.11e-01
tRNA modification in the nucleus and cytosol	34	4.60e-02	1.21e-01	0.3120	7.09e-02	-4.88e-02	-0.276000	0.119000	4.75e-01	0.62300	5.42e-03	2.32e-01
Peptide ligand-binding receptors	16	4.60e-02	1.21e-01	0.4740	-9.77e-02	-1.49e-01	0.351000	-0.265000	4.99e-01	0.30100	1.52e-02	6.64e-02
Signaling by Hippo	12	4.67e-02	1.22e-01	0.4950	2.25e-01	3.65e-01	0.219000	-0.113000	1.77e-01	0.02860	1.90e-01	4.99e-01
G0 and Early G1	24	4.71e-02	1.23e-01	0.3700	2.03e-01	6.08e-02	-0.286000	0.100000	8.52e-02	0.60600	1.54e-02	3.97e-01
Hyaluronan metabolism	11	4.77e-02	1.24e-01	0.5410	-1.66e-01	-6.48e-02	0.506000	-0.068500	3.39e-01	0.71000	3.68e-03	6.94e-01
Negative regulation of FLT3	13	4.81e-02	1.25e-01	0.5000	-2.95e-01	6.17e-02	0.068200	0.393000	6.59e-02	0.70000	6.70e-01	1.41e-02
Neddylation	179	4.85e-02	1.26e-01	0.1290	5.32e-02	8.39e-03	0.052500	0.105000	2.22e-01	0.84700	2.28e-01	1.64e-02
AKT phosphorylates targets in the cytosol	13	4.89e-02	1.26e-01	0.4950	-2.35e-01	9.93e-02	0.418000	0.070600	1.43e-01	0.53500	9.03e-03	6.60e-01
Fanconi Anemia Pathway	28	4.89e-02	1.26e-01	0.3300	8.66e-02	1.19e-01	-0.295000	0.001020	4.28e-01	0.27600	6.88e-03	9.93e-01
EGFR downregulation	20	5.02e-02	1.29e-01	0.4020	-2.58e-01	1.46e-01	0.271000	0.004980	4.55e-02	0.25800	3.59e-02	9.69e-01
Late Phase of HIV Life Cycle	115	5.14e-02	1.32e-01	0.1680	6.62e-02	2.37e-02	-0.036300	0.148000	2.22e-01	0.66200	5.03e-01	6.28e-03
Host Interactions of HIV factors	106	5.14e-02	1.32e-01	0.1820	3.96e-02	4.73e-02	-0.070400	0.156000	4.82e-01	0.40100	2.12e-01	5.67e-03
UCH proteinases	74	5.21e-02	1.33e-01	0.1930	-4.91e-02	-1.42e-02	0.128000	0.135000	4.66e-01	0.83300	5.68e-02	4.54e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	25	5.21e-02	1.33e-01	0.3710	-2.03e-01	2.70e-01	0.127000	0.086200	7.95e-02	0.01970	2.70e-01	4.56e-01
Condensation of Prophase Chromosomes	11	5.32e-02	1.36e-01	0.5450	2.87e-01	-2.10e-01	-0.341000	-0.235000	1.00e-01	0.22800	5.06e-02	1.77e-01
Activation of gene expression by SREBF (SREBP)	34	5.42e-02	1.38e-01	0.2820	9.59e-03	1.77e-01	0.140000	-0.169000	9.23e-01	0.07470	1.59e-01	8.88e-02
MTOR signalling	37	5.53e-02	1.40e-01	0.2900	-1.74e-02	9.75e-02	0.265000	0.064700	8.55e-01	0.30500	5.38e-03	4.96e-01
Class A/1 (Rhodopsin-like receptors)	40	5.53e-02	1.40e-01	0.2890	-1.12e-01	-5.72e-02	0.173000	-0.194000	2.20e-01	0.53200	5.89e-02	3.37e-02
Ca2+ pathway	39	5.54e-02	1.40e-01	0.2950	8.12e-02	1.72e-01	0.105000	0.199000	3.81e-01	0.06300	2.55e-01	3.18e-02
Respiratory electron transport	81	5.60e-02	1.41e-01	0.1870	-1.03e-01	-4.10e-02	0.141000	0.050500	1.10e-01	0.52500	2.82e-02	4.33e-01
Signaling by MET	42	5.76e-02	1.45e-01	0.2760	4.94e-02	1.57e-01	0.194000	0.106000	5.80e-01	0.07940	2.96e-02	2.35e-01
Autophagy	104	5.80e-02	1.46e-01	0.1720	-4.76e-02	-2.87e-02	0.161000	-0.023200	4.03e-01	0.61400	4.56e-03	6.83e-01
Epigenetic regulation of gene expression	72	5.91e-02	1.48e-01	0.2090	4.90e-02	-4.64e-03	-0.125000	0.160000	4.73e-01	0.94600	6.78e-02	1.93e-02
Organelle biogenesis and maintenance	197	5.95e-02	1.49e-01	0.1230	1.05e-01	3.44e-02	-0.054800	0.008740	1.18e-02	0.40800	1.88e-01	8.34e-01
Cyclin E associated events during G1/S transition	72	5.98e-02	1.49e-01	0.1890	1.02e-01	-5.48e-02	0.036700	0.145000	1.37e-01	0.42300	5.91e-01	3.43e-02
TCR signaling	88	6.03e-02	1.50e-01	0.1650	2.20e-02	-6.10e-02	0.038200	0.147000	7.22e-01	0.32400	5.37e-01	1.71e-02
Downstream signaling events of B Cell Receptor (BCR)	70	6.07e-02	1.51e-01	0.1920	4.74e-02	-2.58e-02	0.059400	0.174000	4.94e-01	0.70900	3.91e-01	1.19e-02
SCF-beta-TrCP mediated degradation of Emi1	47	6.12e-02	1.52e-01	0.2280	7.21e-02	-6.57e-02	0.111000	0.174000	3.93e-01	0.43700	1.87e-01	3.95e-02
RNA Polymerase II Transcription Termination	42	6.17e-02	1.53e-01	0.2740	1.83e-01	1.52e-01	-0.058900	0.122000	4.02e-02	0.08830	5.09e-01	1.70e-01
Fatty acid metabolism	102	6.25e-02	1.54e-01	0.1730	2.36e-02	1.07e-01	0.133000	0.016600	6.81e-01	0.06380	2.03e-02	7.73e-01
Mitotic Prophase	73	6.30e-02	1.55e-01	0.2020	1.50e-01	-8.10e-02	-0.097600	0.044600	2.69e-02	0.23300	1.50e-01	5.11e-01
Cyclin A:Cdk2-associated events at S phase entry	74	6.31e-02	1.55e-01	0.1850	9.00e-02	-5.01e-02	0.024900	0.152000	1.82e-01	0.45800	7.12e-01	2.45e-02
MyD88 dependent cascade initiated on endosome	67	6.48e-02	1.58e-01	0.2110	-6.66e-02	-3.86e-02	0.194000	-0.025500	3.47e-01	0.58600	6.05e-03	7.18e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	67	6.48e-02	1.58e-01	0.2110	-6.66e-02	-3.86e-02	0.194000	-0.025500	3.47e-01	0.58600	6.05e-03	7.18e-01
Notch-HLH transcription pathway	21	6.48e-02	1.58e-01	0.3700	-1.54e-01	2.37e-02	0.330000	0.065200	2.22e-01	0.85100	8.97e-03	6.05e-01
COPII-mediated vesicle transport	51	6.54e-02	1.59e-01	0.2430	7.53e-02	9.66e-03	0.229000	-0.023500	3.53e-01	0.90500	4.70e-03	7.72e-01
mRNA 3’-end processing	35	6.69e-02	1.63e-01	0.2940	2.10e-01	9.49e-02	-0.019500	0.181000	3.15e-02	0.33200	8.42e-01	6.45e-02
Prolonged ERK activation events	13	6.72e-02	1.63e-01	0.4430	2.91e-02	-3.13e-02	0.340000	0.280000	8.56e-01	0.84500	3.36e-02	8.03e-02
Pausing and recovery of Tat-mediated HIV elongation	25	6.79e-02	1.64e-01	0.3510	-3.27e-01	7.27e-02	-0.011400	0.106000	4.74e-03	0.53000	9.21e-01	3.60e-01
Tat-mediated HIV elongation arrest and recovery	25	6.79e-02	1.64e-01	0.3510	-3.27e-01	7.27e-02	-0.011400	0.106000	4.74e-03	0.53000	9.21e-01	3.60e-01
ABC-family proteins mediated transport	72	6.79e-02	1.64e-01	0.1810	3.60e-02	-5.83e-02	0.110000	0.127000	5.98e-01	0.39300	1.07e-01	6.36e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	77	6.85e-02	1.65e-01	0.1760	2.65e-02	-4.72e-02	0.115000	0.122000	6.88e-01	0.47500	8.08e-02	6.49e-02
Signal amplification	19	6.92e-02	1.66e-01	0.3800	3.16e-03	3.59e-02	0.350000	0.144000	9.81e-01	0.78600	8.31e-03	2.77e-01
Late endosomal microautophagy	23	6.96e-02	1.67e-01	0.3490	-1.78e-01	-1.59e-02	0.297000	0.039400	1.40e-01	0.89500	1.36e-02	7.44e-01
Pyroptosis	18	7.13e-02	1.70e-01	0.3600	1.54e-01	-1.73e-01	0.179000	0.210000	2.59e-01	0.20500	1.89e-01	1.23e-01
Signaling by Insulin receptor	42	7.13e-02	1.70e-01	0.2540	-9.02e-02	-2.22e-02	0.229000	0.059200	3.12e-01	0.80300	1.05e-02	5.07e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	66	7.16e-02	1.71e-01	0.2090	-7.62e-02	-4.84e-02	0.186000	-0.028900	2.85e-01	0.49700	8.94e-03	6.85e-01
Post-translational protein phosphorylation	32	7.17e-02	1.71e-01	0.3030	-7.41e-02	1.01e-02	0.288000	-0.057100	4.69e-01	0.92100	4.89e-03	5.77e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	15	7.19e-02	1.71e-01	0.4100	-2.35e-01	-1.35e-01	0.275000	0.138000	1.16e-01	0.36600	6.53e-02	3.55e-01
Sema4D in semaphorin signaling	15	7.21e-02	1.71e-01	0.4250	-6.14e-02	3.66e-02	0.386000	0.164000	6.80e-01	0.80600	9.66e-03	2.73e-01
SUMOylation of transcription factors	12	7.23e-02	1.71e-01	0.4870	3.18e-01	3.05e-01	0.187000	0.089800	5.65e-02	0.06730	2.62e-01	5.90e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	15	7.33e-02	1.73e-01	0.4530	-3.61e-02	-4.13e-01	-0.123000	-0.135000	8.09e-01	0.00565	4.09e-01	3.65e-01
Translesion synthesis by POLI	15	7.34e-02	1.73e-01	0.4680	3.92e-02	1.76e-01	-0.320000	0.289000	7.93e-01	0.23700	3.19e-02	5.25e-02
Cell surface interactions at the vascular wall	57	7.38e-02	1.73e-01	0.2160	-1.59e-01	-1.34e-01	0.058800	-0.001570	3.83e-02	0.08050	4.43e-01	9.84e-01
Anti-inflammatory response favouring Leishmania parasite infection	51	7.39e-02	1.73e-01	0.2390	-1.01e-01	9.57e-02	0.194000	-0.010500	2.15e-01	0.23800	1.68e-02	8.97e-01
Leishmania parasite growth and survival	51	7.39e-02	1.73e-01	0.2390	-1.01e-01	9.57e-02	0.194000	-0.010500	2.15e-01	0.23800	1.68e-02	8.97e-01
Processing of Capped Intronless Pre-mRNA	21	7.45e-02	1.74e-01	0.3660	2.01e-01	2.75e-01	-0.111000	0.072000	1.11e-01	0.02910	3.79e-01	5.68e-01
RHOG GTPase cycle	51	7.50e-02	1.75e-01	0.2310	1.93e-02	1.91e-02	0.222000	0.058000	8.12e-01	0.81400	6.07e-03	4.74e-01
Pexophagy	10	7.57e-02	1.76e-01	0.5190	-3.66e-01	-3.62e-01	0.050200	-0.047500	4.50e-02	0.04780	7.84e-01	7.95e-01
Metabolism of polyamines	48	7.66e-02	1.77e-01	0.2200	6.97e-02	-6.52e-02	0.132000	0.148000	4.04e-01	0.43500	1.15e-01	7.69e-02
G beta:gamma signalling through BTK	10	7.67e-02	1.77e-01	0.5170	8.62e-02	9.88e-02	0.272000	0.420000	6.37e-01	0.58900	1.36e-01	2.15e-02
MET promotes cell motility	13	7.67e-02	1.77e-01	0.4890	1.61e-01	3.44e-01	0.150000	0.268000	3.14e-01	0.03180	3.49e-01	9.39e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	10	7.68e-02	1.77e-01	0.5520	3.28e-01	-4.53e-02	0.247000	-0.365000	7.22e-02	0.80400	1.77e-01	4.56e-02
Regulation of PTEN gene transcription	49	7.70e-02	1.77e-01	0.2410	-2.09e-01	1.88e-02	0.064700	0.097400	1.13e-02	0.82000	4.34e-01	2.39e-01
TRAF6 mediated IRF7 activation	15	7.85e-02	1.80e-01	0.4270	2.78e-01	2.32e-01	0.226000	0.012100	6.22e-02	0.12000	1.30e-01	9.35e-01
Thrombin signalling through proteinase activated receptors (PARs)	19	7.88e-02	1.81e-01	0.3780	-1.26e-01	3.26e-02	0.343000	0.088700	3.43e-01	0.80600	9.62e-03	5.03e-01
Signaling by Leptin	10	7.96e-02	1.82e-01	0.5260	-3.33e-01	8.83e-02	0.314000	0.244000	6.83e-02	0.62900	8.60e-02	1.81e-01
PI3K Cascade	18	7.97e-02	1.82e-01	0.3900	-2.86e-01	-6.28e-02	-0.120000	0.227000	3.55e-02	0.64500	3.78e-01	9.60e-02
Transcriptional regulation by RUNX1	133	8.01e-02	1.83e-01	0.1340	-2.89e-02	-2.05e-02	0.056200	0.116000	5.67e-01	0.68500	2.65e-01	2.11e-02
Metabolism of proteins	1261	8.10e-02	1.84e-01	0.0472	2.67e-02	-1.14e-02	-0.001390	0.037200	1.27e-01	0.51400	9.37e-01	3.36e-02
Energy dependent regulation of mTOR by LKB1-AMPK	26	8.27e-02	1.86e-01	0.3260	5.46e-02	9.10e-02	0.308000	0.006770	6.30e-01	0.42200	6.52e-03	9.52e-01
MicroRNA (miRNA) biogenesis	20	8.28e-02	1.86e-01	0.3870	-1.46e-01	7.93e-02	-0.054900	0.345000	2.60e-01	0.54000	6.71e-01	7.52e-03
DNA Damage Bypass	41	8.29e-02	1.86e-01	0.2700	1.18e-01	8.99e-02	-0.180000	0.136000	1.91e-01	0.32000	4.70e-02	1.33e-01
Signaling by CSF3 (G-CSF)	24	8.30e-02	1.86e-01	0.3260	-9.80e-03	-6.10e-03	0.305000	0.115000	9.34e-01	0.95900	9.74e-03	3.32e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	40	8.33e-02	1.86e-01	0.2450	-1.19e-02	-5.60e-02	0.216000	0.101000	8.96e-01	0.54100	1.83e-02	2.70e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	40	8.33e-02	1.86e-01	0.2450	-1.19e-02	-5.60e-02	0.216000	0.101000	8.96e-01	0.54100	1.83e-02	2.70e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	40	8.33e-02	1.86e-01	0.2450	-1.19e-02	-5.60e-02	0.216000	0.101000	8.96e-01	0.54100	1.83e-02	2.70e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	40	8.33e-02	1.86e-01	0.2450	-1.19e-02	-5.60e-02	0.216000	0.101000	8.96e-01	0.54100	1.83e-02	2.70e-01
Signaling by NOTCH1 in Cancer	40	8.33e-02	1.86e-01	0.2450	-1.19e-02	-5.60e-02	0.216000	0.101000	8.96e-01	0.54100	1.83e-02	2.70e-01
Early Phase of HIV Life Cycle	13	8.38e-02	1.87e-01	0.4610	1.22e-01	2.37e-01	-0.366000	0.088300	4.48e-01	0.13900	2.24e-02	5.82e-01
VEGFA-VEGFR2 Pathway	71	8.43e-02	1.87e-01	0.1980	-7.57e-02	3.64e-02	0.176000	-0.035400	2.71e-01	0.59700	1.04e-02	6.07e-01
MyD88 cascade initiated on plasma membrane	65	8.44e-02	1.87e-01	0.2070	-5.92e-02	-2.62e-02	0.194000	-0.029100	4.10e-01	0.71600	6.95e-03	6.86e-01
Toll Like Receptor 10 (TLR10) Cascade	65	8.44e-02	1.87e-01	0.2070	-5.92e-02	-2.62e-02	0.194000	-0.029100	4.10e-01	0.71600	6.95e-03	6.86e-01
Toll Like Receptor 5 (TLR5) Cascade	65	8.44e-02	1.87e-01	0.2070	-5.92e-02	-2.62e-02	0.194000	-0.029100	4.10e-01	0.71600	6.95e-03	6.86e-01
Cell recruitment (pro-inflammatory response)	15	8.49e-02	1.87e-01	0.4460	2.20e-01	-1.15e-01	0.338000	-0.150000	1.41e-01	0.44000	2.33e-02	3.15e-01
Purinergic signaling in leishmaniasis infection	15	8.49e-02	1.87e-01	0.4460	2.20e-01	-1.15e-01	0.338000	-0.150000	1.41e-01	0.44000	2.33e-02	3.15e-01
Signaling by VEGF	73	8.49e-02	1.87e-01	0.1950	-9.14e-02	2.99e-02	0.167000	-0.032400	1.78e-01	0.66000	1.39e-02	6.33e-01
Biological oxidations	77	8.53e-02	1.87e-01	0.1790	3.56e-02	4.18e-02	0.042800	-0.165000	5.90e-01	0.52700	5.17e-01	1.24e-02
SARS-CoV-1 Infection	43	8.54e-02	1.87e-01	0.2360	-1.01e-01	-3.28e-02	0.147000	0.151000	2.54e-01	0.71000	9.58e-02	8.81e-02
Response of Mtb to phagocytosis	20	8.55e-02	1.87e-01	0.3430	-1.50e-01	-1.47e-01	0.251000	0.102000	2.47e-01	0.25400	5.18e-02	4.28e-01
Regulation of APC/C activators between G1/S and early anaphase	70	8.60e-02	1.88e-01	0.1830	1.24e-01	-7.71e-02	0.018300	0.110000	7.41e-02	0.26600	7.91e-01	1.13e-01
Oncogene Induced Senescence	30	8.68e-02	1.90e-01	0.2710	-9.79e-02	-1.22e-01	0.168000	0.144000	3.54e-01	0.24800	1.12e-01	1.72e-01
VxPx cargo-targeting to cilium	16	8.72e-02	1.90e-01	0.3960	1.95e-01	-1.58e-02	0.311000	0.148000	1.78e-01	0.91300	3.12e-02	3.06e-01
HIV elongation arrest and recovery	26	8.75e-02	1.90e-01	0.3310	-2.97e-01	5.60e-02	0.006010	0.135000	8.75e-03	0.62100	9.58e-01	2.35e-01
Pausing and recovery of HIV elongation	26	8.75e-02	1.90e-01	0.3310	-2.97e-01	5.60e-02	0.006010	0.135000	8.75e-03	0.62100	9.58e-01	2.35e-01
Meiotic recombination	16	8.77e-02	1.90e-01	0.4140	3.37e-01	-1.20e-01	-0.208000	0.016300	1.96e-02	0.40400	1.51e-01	9.10e-01
Signaling by the B Cell Receptor (BCR)	91	8.86e-02	1.91e-01	0.1610	1.18e-02	-1.12e-02	0.071300	0.143000	8.47e-01	0.85400	2.41e-01	1.88e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	14	8.86e-02	1.91e-01	0.4320	-3.05e-01	2.19e-01	0.182000	-0.113000	4.79e-02	0.15700	2.40e-01	4.66e-01
Nucleobase biosynthesis	10	8.90e-02	1.92e-01	0.5200	-1.97e-01	-1.20e-01	-0.465000	0.037600	2.81e-01	0.51100	1.09e-02	8.37e-01
Iron uptake and transport	38	8.95e-02	1.92e-01	0.2730	7.11e-02	1.08e-02	0.245000	-0.096300	4.49e-01	0.90800	9.09e-03	3.05e-01
Antigen processing: Ubiquitination & Proteasome degradation	236	9.00e-02	1.93e-01	0.1040	7.95e-02	1.21e-03	0.031400	0.059800	3.68e-02	0.97500	4.10e-01	1.16e-01
G beta:gamma signalling through PLC beta	12	9.02e-02	1.93e-01	0.4670	-4.71e-03	1.23e-01	0.376000	0.248000	9.77e-01	0.46000	2.41e-02	1.36e-01
Presynaptic function of Kainate receptors	12	9.02e-02	1.93e-01	0.4670	-4.71e-03	1.23e-01	0.376000	0.248000	9.77e-01	0.46000	2.41e-02	1.36e-01
RIPK1-mediated regulated necrosis	24	9.20e-02	1.96e-01	0.3030	1.39e-01	-1.91e-01	0.133000	0.135000	2.38e-01	0.10600	2.59e-01	2.52e-01
Regulation of necroptotic cell death	24	9.20e-02	1.96e-01	0.3030	1.39e-01	-1.91e-01	0.133000	0.135000	2.38e-01	0.10600	2.59e-01	2.52e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	14	9.21e-02	1.96e-01	0.4270	1.60e-01	2.51e-01	0.294000	-0.087800	3.00e-01	0.10500	5.67e-02	5.70e-01
Signaling by Nuclear Receptors	147	9.23e-02	1.96e-01	0.1330	-1.12e-01	-1.30e-02	0.007180	0.070300	1.95e-02	0.78600	8.81e-01	1.43e-01
Glycosphingolipid metabolism	27	9.33e-02	1.97e-01	0.3160	-1.19e-01	9.70e-02	0.274000	-0.031900	2.84e-01	0.38400	1.38e-02	7.74e-01
RHOJ GTPase cycle	36	9.33e-02	1.97e-01	0.2740	5.08e-03	7.08e-02	0.244000	-0.102000	9.58e-01	0.46300	1.14e-02	2.92e-01
ERK/MAPK targets	17	9.45e-02	1.99e-01	0.3920	2.26e-02	1.82e-01	0.332000	-0.100000	8.72e-01	0.19500	1.79e-02	4.74e-01
Metabolism of steroid hormones	12	9.60e-02	2.02e-01	0.4390	1.16e-01	-3.16e-02	0.339000	0.253000	4.89e-01	0.85000	4.23e-02	1.29e-01
Translesion synthesis by REV1	14	9.64e-02	2.03e-01	0.4600	-1.65e-02	1.29e-01	-0.361000	0.253000	9.15e-01	0.40500	1.94e-02	1.01e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	10	9.70e-02	2.03e-01	0.5320	-1.31e-01	-7.95e-02	0.409000	-0.304000	4.72e-01	0.66300	2.52e-02	9.59e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	22	9.72e-02	2.03e-01	0.3150	-1.04e-01	-7.22e-02	0.177000	0.228000	3.97e-01	0.55800	1.51e-01	6.44e-02
ESR-mediated signaling	112	9.72e-02	2.03e-01	0.1550	-9.46e-02	1.66e-02	0.016500	0.120000	8.47e-02	0.76200	7.63e-01	2.83e-02
O-linked glycosylation of mucins	26	9.76e-02	2.04e-01	0.3240	-1.74e-02	1.74e-02	0.240000	-0.217000	8.78e-01	0.87800	3.45e-02	5.55e-02
Peroxisomal lipid metabolism	22	9.84e-02	2.05e-01	0.3460	1.07e-01	1.22e-01	0.170000	0.254000	3.86e-01	0.32400	1.68e-01	3.93e-02
GABA receptor activation	18	9.85e-02	2.05e-01	0.3760	-2.64e-04	8.03e-02	0.347000	0.122000	9.98e-01	0.55500	1.09e-02	3.69e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	17	9.89e-02	2.05e-01	0.3910	6.69e-02	-5.03e-02	-0.234000	0.302000	6.33e-01	0.72000	9.57e-02	3.12e-02
Downstream TCR signaling	72	9.97e-02	2.07e-01	0.1730	2.33e-02	-4.25e-02	0.033300	0.163000	7.33e-01	0.53400	6.26e-01	1.70e-02
RHO GTPase Effectors	183	1.01e-01	2.08e-01	0.1210	8.15e-02	-2.00e-02	0.086600	-0.004750	5.88e-02	0.64300	4.45e-02	9.12e-01
Complex I biogenesis	43	1.02e-01	2.10e-01	0.2390	-1.31e-01	-6.70e-02	0.189000	0.006810	1.37e-01	0.44800	3.25e-02	9.39e-01
Constitutive Signaling by AKT1 E17K in Cancer	23	1.02e-01	2.10e-01	0.3340	-2.79e-01	2.30e-02	0.173000	0.055400	2.05e-02	0.84900	1.51e-01	6.46e-01
Post NMDA receptor activation events	37	1.03e-01	2.11e-01	0.2800	-7.78e-02	-9.01e-02	0.153000	-0.202000	4.13e-01	0.34300	1.07e-01	3.36e-02
Transcription of E2F targets under negative control by DREAM complex	18	1.05e-01	2.16e-01	0.3790	1.59e-01	-9.38e-02	-0.317000	0.092700	2.43e-01	0.49100	1.98e-02	4.96e-01
mRNA Splicing - Major Pathway	144	1.06e-01	2.18e-01	0.1360	3.68e-03	9.88e-03	-0.132000	0.030700	9.40e-01	0.83900	6.41e-03	5.27e-01
Synthesis of PC	19	1.07e-01	2.18e-01	0.3640	1.80e-01	1.25e-01	0.248000	0.153000	1.75e-01	0.34600	6.18e-02	2.50e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	19	1.07e-01	2.18e-01	0.3690	-4.23e-02	1.48e-01	0.322000	0.094400	7.50e-01	0.26300	1.53e-02	4.77e-01
Neurodegenerative Diseases	19	1.07e-01	2.18e-01	0.3690	-4.23e-02	1.48e-01	0.322000	0.094400	7.50e-01	0.26300	1.53e-02	4.77e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	24	1.07e-01	2.19e-01	0.3570	-6.94e-02	2.21e-01	-0.183000	0.201000	5.57e-01	0.06080	1.21e-01	8.85e-02
C-type lectin receptors (CLRs)	100	1.08e-01	2.19e-01	0.1520	2.40e-02	3.26e-03	0.118000	0.091700	6.80e-01	0.95500	4.14e-02	1.14e-01
ADP signalling through P2Y purinoceptor 1	15	1.09e-01	2.21e-01	0.4080	4.64e-02	1.02e-01	0.378000	0.104000	7.56e-01	0.49600	1.13e-02	4.87e-01
FOXO-mediated transcription of cell death genes	14	1.10e-01	2.23e-01	0.4250	-3.06e-01	7.30e-02	0.286000	-0.001790	4.74e-02	0.63600	6.39e-02	9.91e-01
Processive synthesis on the C-strand of the telomere	17	1.10e-01	2.23e-01	0.4000	-1.72e-02	2.44e-02	-0.318000	0.241000	9.02e-01	0.86200	2.33e-02	8.49e-02
Processive synthesis on the lagging strand	13	1.11e-01	2.23e-01	0.4420	7.72e-02	-1.47e-01	-0.408000	0.029800	6.30e-01	0.35800	1.08e-02	8.52e-01
Post-translational modification: synthesis of GPI-anchored proteins	28	1.11e-01	2.23e-01	0.3180	5.21e-02	2.81e-01	0.005640	0.140000	6.34e-01	0.01010	9.59e-01	1.99e-01
Gap junction trafficking and regulation	10	1.11e-01	2.24e-01	0.5100	-1.88e-01	-7.10e-02	0.439000	-0.165000	3.05e-01	0.69800	1.63e-02	3.66e-01
Activation of HOX genes during differentiation	38	1.12e-01	2.25e-01	0.2640	-1.19e-01	6.21e-02	0.041400	0.223000	2.04e-01	0.50800	6.59e-01	1.74e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis	38	1.12e-01	2.25e-01	0.2640	-1.19e-01	6.21e-02	0.041400	0.223000	2.04e-01	0.50800	6.59e-01	1.74e-02
TNF signaling	37	1.14e-01	2.27e-01	0.2350	3.76e-02	-2.15e-01	0.020800	0.086000	6.93e-01	0.02390	8.27e-01	3.66e-01
Meiosis	38	1.14e-01	2.27e-01	0.2590	1.45e-01	-1.03e-01	-0.188000	-0.004280	1.21e-01	0.27100	4.54e-02	9.64e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	10	1.14e-01	2.27e-01	0.5200	4.19e-01	-2.57e-01	-0.106000	-0.135000	2.19e-02	0.16000	5.62e-01	4.58e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	25	1.14e-01	2.27e-01	0.3440	-5.48e-02	1.84e-01	-0.209000	0.195000	6.35e-01	0.11100	7.12e-02	9.19e-02
Condensation of Prometaphase Chromosomes	10	1.15e-01	2.28e-01	0.4970	4.83e-01	6.47e-05	-0.113000	0.029500	8.24e-03	1.00000	5.37e-01	8.72e-01
Mismatch Repair	13	1.15e-01	2.28e-01	0.4400	1.79e-02	-7.79e-02	-0.341000	0.266000	9.11e-01	0.62700	3.34e-02	9.66e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	16	1.15e-01	2.28e-01	0.3980	-3.45e-01	4.31e-02	0.071800	0.179000	1.70e-02	0.76500	6.19e-01	2.14e-01
Macroautophagy	95	1.16e-01	2.29e-01	0.1620	-3.92e-02	-2.97e-02	0.153000	-0.014700	5.10e-01	0.61800	1.00e-02	8.05e-01
RAF activation	28	1.16e-01	2.30e-01	0.2950	2.34e-01	-7.42e-03	0.177000	0.029700	3.24e-02	0.94600	1.05e-01	7.86e-01
SUMOylation of immune response proteins	10	1.17e-01	2.31e-01	0.5200	-8.86e-02	2.95e-01	0.294000	0.299000	6.28e-01	0.10600	1.08e-01	1.02e-01
PIWI-interacting RNA (piRNA) biogenesis	15	1.19e-01	2.34e-01	0.4360	-1.82e-01	1.34e-01	-0.256000	0.270000	2.22e-01	0.36900	8.56e-02	6.99e-02
Toll Like Receptor 9 (TLR9) Cascade	70	1.19e-01	2.35e-01	0.1850	-5.42e-02	-3.68e-02	0.173000	-0.006050	4.34e-01	0.59600	1.23e-02	9.30e-01
Extra-nuclear estrogen signaling	48	1.20e-01	2.36e-01	0.2190	-1.39e-01	-1.21e-02	0.047500	0.161000	9.50e-02	0.88500	5.70e-01	5.38e-02
Transport of bile salts and organic acids, metal ions and amine compounds	30	1.21e-01	2.37e-01	0.2930	5.04e-04	-9.16e-02	0.266000	-0.082200	9.96e-01	0.38500	1.18e-02	4.36e-01
Regulation of IFNA signaling	12	1.23e-01	2.40e-01	0.4150	7.28e-02	-2.18e-01	0.320000	0.130000	6.62e-01	0.19100	5.48e-02	4.36e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	1.24e-01	2.42e-01	0.4550	2.85e-02	-5.32e-02	-0.353000	0.281000	8.64e-01	0.75000	3.45e-02	9.16e-02
RMTs methylate histone arginines	25	1.24e-01	2.42e-01	0.3270	-2.39e-01	1.17e-01	-0.155000	0.109000	3.84e-02	0.31300	1.80e-01	3.45e-01
Mitophagy	23	1.28e-01	2.49e-01	0.3070	-2.19e-01	2.53e-02	-0.117000	-0.178000	6.90e-02	0.83400	3.30e-01	1.40e-01
Deadenylation-dependent mRNA decay	50	1.28e-01	2.49e-01	0.2200	9.53e-02	-3.69e-02	-0.186000	0.059200	2.44e-01	0.65200	2.30e-02	4.70e-01
mRNA Splicing	151	1.29e-01	2.50e-01	0.1280	1.60e-02	3.04e-03	-0.125000	0.024200	7.35e-01	0.94900	8.58e-03	6.09e-01
B-WICH complex positively regulates rRNA expression	24	1.30e-01	2.51e-01	0.3290	7.26e-02	7.02e-02	-0.254000	0.184000	5.39e-01	0.55200	3.16e-02	1.19e-01
Translation of structural proteins	26	1.31e-01	2.54e-01	0.2850	-2.23e-01	-8.65e-02	0.064700	0.140000	4.88e-02	0.44500	5.68e-01	2.18e-01
Amino acid transport across the plasma membrane	16	1.32e-01	2.55e-01	0.4110	-1.38e-01	-2.17e-01	0.054900	-0.316000	3.38e-01	0.13300	7.04e-01	2.88e-02
Platelet sensitization by LDL	13	1.32e-01	2.55e-01	0.4130	1.15e-01	-1.77e-02	0.382000	0.106000	4.71e-01	0.91200	1.71e-02	5.10e-01
GPCR ligand binding	67	1.33e-01	2.55e-01	0.1910	-1.03e-01	-7.81e-03	0.138000	-0.081800	1.47e-01	0.91200	5.05e-02	2.48e-01
TP53 Regulates Transcription of Cell Cycle Genes	42	1.33e-01	2.55e-01	0.2320	7.97e-02	-8.01e-02	-0.155000	0.132000	3.72e-01	0.37000	8.30e-02	1.41e-01
Oxidative Stress Induced Senescence	54	1.33e-01	2.55e-01	0.1930	-1.11e-01	-1.15e-01	0.097100	0.049700	1.59e-01	0.14500	2.18e-01	5.28e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	12	1.35e-01	2.58e-01	0.4650	3.87e-01	-2.06e-01	0.042600	-0.147000	2.03e-02	0.21600	7.98e-01	3.78e-01
HATs acetylate histones	58	1.35e-01	2.58e-01	0.2100	-7.46e-02	2.04e-02	-0.167000	0.102000	3.27e-01	0.78900	2.82e-02	1.81e-01
Interleukin-17 signaling	53	1.35e-01	2.58e-01	0.2200	-4.17e-02	-5.51e-02	0.179000	-0.107000	6.00e-01	0.48900	2.42e-02	1.78e-01
Signaling by NOTCH3	29	1.35e-01	2.58e-01	0.2710	-1.50e-01	-5.33e-02	0.205000	0.078500	1.63e-01	0.62000	5.58e-02	4.65e-01
Cholesterol biosynthesis	20	1.40e-01	2.66e-01	0.3260	1.63e-01	2.02e-01	0.171000	-0.099200	2.08e-01	0.11700	1.86e-01	4.43e-01
Activation of GABAB receptors	17	1.40e-01	2.66e-01	0.3630	-2.49e-02	7.40e-02	0.319000	0.154000	8.59e-01	0.59800	2.29e-02	2.71e-01
GABA B receptor activation	17	1.40e-01	2.66e-01	0.3630	-2.49e-02	7.40e-02	0.319000	0.154000	8.59e-01	0.59800	2.29e-02	2.71e-01
Mitochondrial protein import	47	1.41e-01	2.67e-01	0.2270	-7.00e-02	1.83e-02	-0.208000	0.056600	4.07e-01	0.82800	1.40e-02	5.03e-01
SHC1 events in ERBB2 signaling	11	1.42e-01	2.68e-01	0.4390	-1.01e-01	3.75e-01	0.180000	-0.099000	5.62e-01	0.03150	3.00e-01	5.70e-01
Costimulation by the CD28 family	45	1.47e-01	2.77e-01	0.2120	-5.60e-02	-4.40e-02	-0.024900	0.199000	5.17e-01	0.61000	7.73e-01	2.13e-02
G-protein activation	12	1.48e-01	2.79e-01	0.4320	5.52e-02	1.43e-01	0.358000	0.188000	7.41e-01	0.39200	3.17e-02	2.61e-01
Anchoring of the basal body to the plasma membrane	79	1.49e-01	2.79e-01	0.1690	1.53e-01	1.73e-02	-0.015400	0.067400	1.92e-02	0.79000	8.13e-01	3.02e-01
G alpha (z) signalling events	24	1.49e-01	2.79e-01	0.3140	-1.12e-01	1.25e-01	0.212000	0.159000	3.43e-01	0.29000	7.22e-02	1.79e-01
Diseases associated with the TLR signaling cascade	16	1.50e-01	2.80e-01	0.3650	6.71e-02	-5.31e-02	0.349000	0.062500	6.43e-01	0.71300	1.58e-02	6.66e-01
Diseases of Immune System	16	1.50e-01	2.80e-01	0.3650	6.71e-02	-5.31e-02	0.349000	0.062500	6.43e-01	0.71300	1.58e-02	6.66e-01
Interleukin-10 signaling	13	1.51e-01	2.81e-01	0.4360	-5.79e-02	-7.22e-02	0.284000	-0.318000	7.18e-01	0.65300	7.62e-02	4.72e-02
RHOF GTPase cycle	25	1.53e-01	2.85e-01	0.2950	1.15e-01	6.62e-02	0.104000	0.242000	3.18e-01	0.56700	3.69e-01	3.64e-02
TNFR1-induced NFkappaB signaling pathway	19	1.53e-01	2.85e-01	0.3370	1.09e-01	-3.12e-01	-0.063400	0.019400	4.10e-01	0.01880	6.33e-01	8.83e-01
Post-chaperonin tubulin folding pathway	13	1.53e-01	2.85e-01	0.3870	5.18e-02	-7.34e-02	0.332000	0.177000	7.46e-01	0.64700	3.81e-02	2.70e-01
Hedgehog ‘off’ state	75	1.54e-01	2.86e-01	0.1540	2.24e-02	-5.64e-02	0.095300	0.105000	7.38e-01	0.39900	1.55e-01	1.16e-01
RNA Polymerase I Promoter Clearance	41	1.55e-01	2.86e-01	0.2410	2.37e-02	7.69e-03	-0.191000	0.145000	7.93e-01	0.93200	3.48e-02	1.08e-01
RNA Polymerase I Transcription	41	1.55e-01	2.86e-01	0.2410	2.37e-02	7.69e-03	-0.191000	0.145000	7.93e-01	0.93200	3.48e-02	1.08e-01
Insulin receptor signalling cascade	26	1.55e-01	2.86e-01	0.2740	-2.10e-01	-9.35e-02	0.064900	0.135000	6.43e-02	0.40900	5.67e-01	2.33e-01
Cellular Senescence	105	1.56e-01	2.88e-01	0.1390	-9.62e-02	-2.36e-02	0.080300	0.055900	8.97e-02	0.67600	1.57e-01	3.24e-01
Integrin signaling	17	1.58e-01	2.91e-01	0.3630	-3.95e-02	-5.90e-02	0.351000	-0.057000	7.78e-01	0.67400	1.22e-02	6.84e-01
Platelet Aggregation (Plug Formation)	17	1.58e-01	2.91e-01	0.3630	-3.95e-02	-5.90e-02	0.351000	-0.057000	7.78e-01	0.67400	1.22e-02	6.84e-01
Cardiac conduction	40	1.59e-01	2.91e-01	0.2550	-6.30e-02	-1.77e-01	0.015300	-0.171000	4.91e-01	0.05270	8.67e-01	6.12e-02
Interleukin-20 family signaling	13	1.59e-01	2.91e-01	0.3730	5.43e-02	-1.11e-01	0.269000	0.228000	7.35e-01	0.48900	9.36e-02	1.55e-01
FCERI mediated MAPK activation	25	1.60e-01	2.92e-01	0.2980	-6.71e-02	1.09e-01	0.268000	-0.024500	5.62e-01	0.34500	2.03e-02	8.32e-01
PINK1-PRKN Mediated Mitophagy	18	1.60e-01	2.92e-01	0.3390	-2.16e-01	-3.53e-02	-0.202000	-0.162000	1.12e-01	0.79600	1.38e-01	2.35e-01
The citric acid (TCA) cycle and respiratory electron transport	120	1.60e-01	2.92e-01	0.1270	-3.85e-02	-2.56e-02	0.103000	0.058200	4.67e-01	0.63000	5.24e-02	2.72e-01
AURKA Activation by TPX2	58	1.61e-01	2.93e-01	0.1970	1.55e-01	8.16e-02	0.008610	0.088600	4.14e-02	0.28300	9.10e-01	2.44e-01
mTORC1-mediated signalling	22	1.61e-01	2.93e-01	0.3140	-1.01e-01	7.85e-02	0.255000	0.132000	4.11e-01	0.52400	3.85e-02	2.85e-01
Sema4D induced cell migration and growth-cone collapse	12	1.63e-01	2.96e-01	0.4080	-1.39e-01	-7.42e-02	0.363000	0.100000	4.05e-01	0.65600	2.96e-02	5.47e-01
MyD88-independent TLR4 cascade	75	1.64e-01	2.96e-01	0.1640	6.52e-03	-1.68e-02	0.156000	0.047700	9.22e-01	0.80200	1.98e-02	4.76e-01
TRIF(TICAM1)-mediated TLR4 signaling	75	1.64e-01	2.96e-01	0.1640	6.52e-03	-1.68e-02	0.156000	0.047700	9.22e-01	0.80200	1.98e-02	4.76e-01
Activation of G protein gated Potassium channels	11	1.66e-01	2.99e-01	0.4220	1.18e-01	2.70e-02	0.269000	0.301000	4.97e-01	0.87700	1.22e-01	8.42e-02
G protein gated Potassium channels	11	1.66e-01	2.99e-01	0.4220	1.18e-01	2.70e-02	0.269000	0.301000	4.97e-01	0.87700	1.22e-01	8.42e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	11	1.66e-01	2.99e-01	0.4220	1.18e-01	2.70e-02	0.269000	0.301000	4.97e-01	0.87700	1.22e-01	8.42e-02
Nicotinate metabolism	19	1.67e-01	2.99e-01	0.3360	1.62e-01	-1.95e-01	0.221000	-0.013800	2.21e-01	0.14200	9.60e-02	9.17e-01
Synthesis of very long-chain fatty acyl-CoAs	16	1.67e-01	2.99e-01	0.3720	1.62e-01	8.59e-02	-0.014300	0.323000	2.63e-01	0.55200	9.21e-01	2.52e-02
Platelet homeostasis	47	1.68e-01	3.00e-01	0.2120	-3.74e-02	-9.22e-02	0.186000	-0.014100	6.58e-01	0.27500	2.75e-02	8.67e-01
HSF1-dependent transactivation	25	1.70e-01	3.04e-01	0.2790	-2.28e-01	-1.46e-01	-0.007470	0.065700	4.88e-02	0.20600	9.49e-01	5.70e-01
Smooth Muscle Contraction	19	1.70e-01	3.04e-01	0.3400	-1.72e-01	-5.50e-02	0.272000	-0.096500	1.96e-01	0.67800	4.05e-02	4.67e-01
Protein folding	62	1.71e-01	3.05e-01	0.1840	4.07e-02	4.97e-02	0.143000	0.096400	5.80e-01	0.49900	5.27e-02	1.90e-01
Nuclear signaling by ERBB4	16	1.71e-01	3.05e-01	0.3660	-1.64e-01	-2.10e-01	0.238000	-0.077300	2.55e-01	0.14500	1.00e-01	5.93e-01
Platelet calcium homeostasis	16	1.72e-01	3.05e-01	0.3810	-2.08e-01	-1.99e-01	0.145000	-0.202000	1.49e-01	0.16800	3.16e-01	1.61e-01
RHOBTB GTPase Cycle	28	1.72e-01	3.05e-01	0.2680	1.99e-01	-4.54e-02	-0.061100	0.163000	6.88e-02	0.67800	5.76e-01	1.36e-01
Signaling by BMP	14	1.72e-01	3.05e-01	0.3750	3.18e-01	-8.25e-02	0.045000	0.176000	3.98e-02	0.59300	7.71e-01	2.55e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	1.72e-01	3.05e-01	0.4200	-1.21e-02	-1.26e-01	-0.334000	0.220000	9.42e-01	0.45000	4.51e-02	1.88e-01
Prostacyclin signalling through prostacyclin receptor	11	1.73e-01	3.05e-01	0.4150	6.45e-02	1.04e-02	0.245000	0.329000	7.11e-01	0.95300	1.60e-01	5.91e-02
Cargo concentration in the ER	20	1.73e-01	3.05e-01	0.3200	1.77e-01	3.69e-02	0.249000	0.089100	1.71e-01	0.77500	5.42e-02	4.90e-01
Josephin domain DUBs	10	1.74e-01	3.06e-01	0.4570	-4.18e-01	-1.02e-01	0.141000	-0.058500	2.20e-02	0.57800	4.40e-01	7.49e-01
Glycogen storage diseases	10	1.75e-01	3.08e-01	0.4610	-3.63e-01	-3.02e-02	0.185000	-0.213000	4.67e-02	0.86900	3.10e-01	2.45e-01
Thromboxane signalling through TP receptor	14	1.76e-01	3.09e-01	0.3810	-1.48e-02	8.46e-02	0.283000	0.240000	9.24e-01	0.58400	6.67e-02	1.20e-01
Signaling by FGFR1 in disease	25	1.76e-01	3.09e-01	0.2880	1.39e-01	3.91e-02	0.110000	-0.224000	2.29e-01	0.73500	3.41e-01	5.30e-02
Keratan sulfate/keratin metabolism	19	1.77e-01	3.09e-01	0.3490	-1.50e-01	2.55e-01	0.159000	0.094700	2.57e-01	0.05420	2.31e-01	4.75e-01
Termination of translesion DNA synthesis	28	1.77e-01	3.09e-01	0.2840	1.04e-01	7.90e-02	-0.217000	0.129000	3.41e-01	0.47000	4.71e-02	2.36e-01
Sema3A PAK dependent Axon repulsion	11	1.77e-01	3.09e-01	0.4710	1.49e-02	-1.44e-01	0.293000	-0.340000	9.32e-01	0.40900	9.29e-02	5.13e-02
Abortive elongation of HIV-1 transcript in the absence of Tat	21	1.77e-01	3.09e-01	0.3400	-2.26e-01	1.72e-01	0.054500	0.178000	7.29e-02	0.17300	6.66e-01	1.59e-01
LDL clearance	13	1.78e-01	3.10e-01	0.3870	-1.06e-01	-3.48e-02	0.354000	0.111000	5.09e-01	0.82800	2.73e-02	4.90e-01
Regulation of TP53 Activity through Methylation	17	1.79e-01	3.11e-01	0.3300	-1.60e-01	-1.96e-01	-0.138000	0.162000	2.55e-01	0.16300	3.25e-01	2.48e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	41	1.81e-01	3.14e-01	0.2310	-1.66e-01	-1.08e-01	0.049600	-0.107000	6.55e-02	0.23400	5.83e-01	2.36e-01
SUMOylation of DNA methylation proteins	14	1.82e-01	3.16e-01	0.3800	-3.42e-01	4.89e-02	-0.140000	-0.072900	2.67e-02	0.75200	3.64e-01	6.37e-01
Gastrin-CREB signalling pathway via PKC and MAPK	12	1.84e-01	3.18e-01	0.4090	-2.11e-01	1.53e-01	0.262000	-0.175000	2.05e-01	0.35800	1.16e-01	2.94e-01
Translesion synthesis by POLK	15	1.85e-01	3.19e-01	0.3940	4.45e-02	1.46e-01	-0.298000	0.207000	7.65e-01	0.32900	4.57e-02	1.65e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	27	1.86e-01	3.21e-01	0.2420	2.74e-02	-1.67e-01	0.012900	0.173000	8.06e-01	0.13300	9.08e-01	1.20e-01
Processing of Intronless Pre-mRNAs	14	1.87e-01	3.22e-01	0.3920	2.78e-01	1.94e-01	-0.038500	0.193000	7.17e-02	0.20900	8.03e-01	2.12e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	10	1.88e-01	3.23e-01	0.4460	1.86e-01	4.06e-02	0.391000	0.096800	3.09e-01	0.82400	3.22e-02	5.96e-01
Calnexin/calreticulin cycle	23	1.89e-01	3.24e-01	0.2750	-8.11e-02	-2.08e-01	0.151000	0.054400	5.01e-01	0.08420	2.09e-01	6.52e-01
Removal of the Flap Intermediate	12	1.90e-01	3.25e-01	0.4150	1.24e-01	-1.25e-01	-0.371000	0.060300	4.57e-01	0.45400	2.60e-02	7.18e-01
DAG and IP3 signaling	26	1.91e-01	3.27e-01	0.2630	-1.04e-01	2.11e-01	0.069000	-0.095300	3.60e-01	0.06220	5.43e-01	4.01e-01
CLEC7A (Dectin-1) signaling	84	1.91e-01	3.27e-01	0.1480	1.94e-02	2.39e-03	0.108000	0.099200	7.59e-01	0.97000	8.87e-02	1.17e-01
The role of Nef in HIV-1 replication and disease pathogenesis	19	1.92e-01	3.27e-01	0.3250	-2.38e-01	1.78e-01	0.118000	-0.056000	7.26e-02	0.17900	3.72e-01	6.73e-01
Activation of NMDA receptors and postsynaptic events	42	1.92e-01	3.27e-01	0.2260	-1.05e-01	-3.44e-02	0.108000	-0.165000	2.38e-01	0.70000	2.27e-01	6.46e-02
CD28 dependent PI3K/Akt signaling	18	1.93e-01	3.28e-01	0.3390	-2.80e-01	-2.05e-02	-0.127000	0.143000	4.00e-02	0.88000	3.51e-01	2.94e-01
Deactivation of the beta-catenin transactivating complex	28	1.95e-01	3.31e-01	0.2920	-1.73e-01	1.50e-01	0.018000	0.180000	1.13e-01	0.17100	8.69e-01	9.92e-02
activated TAK1 mediates p38 MAPK activation	13	1.95e-01	3.32e-01	0.3690	1.15e-01	-1.69e-01	0.289000	0.104000	4.73e-01	0.29200	7.09e-02	5.17e-01
Regulation of MECP2 expression and activity	23	1.99e-01	3.37e-01	0.2640	3.78e-02	-8.33e-02	0.077900	0.235000	7.54e-01	0.48900	5.18e-01	5.09e-02
Regulation of beta-cell development	14	2.00e-01	3.38e-01	0.3780	-3.09e-01	3.65e-02	0.206000	0.055400	4.52e-02	0.81300	1.82e-01	7.20e-01
Signaling by EGFR	36	2.01e-01	3.39e-01	0.2360	-1.70e-01	2.91e-02	0.161000	-0.009470	7.74e-02	0.76300	9.57e-02	9.22e-01
Loss of Nlp from mitotic centrosomes	55	2.01e-01	3.39e-01	0.1940	1.39e-01	9.85e-02	0.013200	0.092800	7.58e-02	0.20700	8.66e-01	2.35e-01
Loss of proteins required for interphase microtubule organization from the centrosome	55	2.01e-01	3.39e-01	0.1940	1.39e-01	9.85e-02	0.013200	0.092800	7.58e-02	0.20700	8.66e-01	2.35e-01
Removal of the Flap Intermediate from the C-strand	15	2.03e-01	3.42e-01	0.3830	-1.09e-02	5.36e-02	-0.277000	0.258000	9.42e-01	0.72000	6.33e-02	8.34e-02
Polymerase switching on the C-strand of the telomere	22	2.03e-01	3.42e-01	0.3110	-6.23e-03	5.68e-02	-0.285000	0.110000	9.60e-01	0.64500	2.09e-02	3.70e-01
Formation of Incision Complex in GG-NER	36	2.05e-01	3.44e-01	0.2340	2.09e-01	5.89e-02	-0.066100	0.055100	3.00e-02	0.54100	4.93e-01	5.68e-01
Infection with Mycobacterium tuberculosis	22	2.05e-01	3.44e-01	0.2800	-6.23e-02	-1.06e-01	0.238000	0.081700	6.13e-01	0.39000	5.37e-02	5.08e-01
Glucagon signaling in metabolic regulation	17	2.05e-01	3.44e-01	0.3440	-4.48e-02	5.80e-02	0.326000	-0.082300	7.49e-01	0.67900	1.99e-02	5.57e-01
FCGR3A-mediated IL10 synthesis	22	2.06e-01	3.44e-01	0.2820	-1.36e-01	6.53e-02	0.039800	-0.235000	2.68e-01	0.59600	7.47e-01	5.66e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	23	2.06e-01	3.44e-01	0.3030	-9.55e-02	1.86e-02	-0.259000	0.124000	4.28e-01	0.87800	3.15e-02	3.03e-01
IRS-related events triggered by IGF1R	22	2.07e-01	3.44e-01	0.2930	-2.36e-01	-1.11e-01	-0.113000	0.071200	5.59e-02	0.36600	3.60e-01	5.64e-01
Regulation of insulin secretion	38	2.12e-01	3.53e-01	0.2330	-6.42e-02	-9.95e-03	0.183000	-0.128000	4.94e-01	0.91600	5.11e-02	1.71e-01
Translesion Synthesis by POLH	16	2.14e-01	3.55e-01	0.3740	-9.12e-02	1.01e-01	-0.254000	0.237000	5.28e-01	0.48300	7.83e-02	1.01e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	10	2.16e-01	3.58e-01	0.4160	1.30e-01	1.64e-02	0.209000	0.335000	4.75e-01	0.92800	2.53e-01	6.64e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	14	2.18e-01	3.61e-01	0.3830	-1.26e-01	4.16e-03	-0.236000	0.274000	4.15e-01	0.97800	1.27e-01	7.59e-02
Cobalamin (Cbl, vitamin B12) transport and metabolism	10	2.23e-01	3.69e-01	0.4230	2.63e-01	-1.69e-01	-0.197000	0.206000	1.50e-01	0.35500	2.80e-01	2.60e-01
Spry regulation of FGF signaling	15	2.24e-01	3.69e-01	0.3510	-1.83e-01	-1.59e-01	0.251000	-0.043100	2.19e-01	0.28700	9.29e-02	7.73e-01
NR1H2 and NR1H3-mediated signaling	26	2.24e-01	3.69e-01	0.2530	-1.47e-01	-4.38e-02	0.104000	0.173000	1.96e-01	0.69900	3.58e-01	1.27e-01
Interleukin receptor SHC signaling	16	2.24e-01	3.69e-01	0.3410	-1.65e-01	5.77e-02	0.181000	0.231000	2.55e-01	0.68900	2.10e-01	1.10e-01
Caspase activation via extrinsic apoptotic signalling pathway	15	2.25e-01	3.69e-01	0.3580	2.04e-01	-1.48e-01	0.253000	-0.024800	1.71e-01	0.32200	8.97e-02	8.68e-01
Chaperonin-mediated protein folding	56	2.26e-01	3.70e-01	0.1850	4.00e-02	7.88e-02	0.142000	0.080600	6.06e-01	0.30800	6.74e-02	2.97e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	26	2.26e-01	3.71e-01	0.2690	-6.60e-02	-2.19e-01	-0.140000	-0.017900	5.61e-01	0.05380	2.16e-01	8.75e-01
Recruitment of NuMA to mitotic centrosomes	63	2.28e-01	3.73e-01	0.1800	9.69e-02	1.26e-01	-0.009500	0.083900	1.84e-01	0.08490	8.96e-01	2.51e-01
Nicotinamide salvaging	11	2.31e-01	3.77e-01	0.4120	3.16e-01	-1.56e-01	0.212000	0.009390	6.94e-02	0.37200	2.23e-01	9.57e-01
Activation of kainate receptors upon glutamate binding	16	2.31e-01	3.77e-01	0.3450	-6.75e-05	1.26e-01	0.213000	0.240000	1.00e+00	0.38100	1.41e-01	9.61e-02
Negative regulation of MET activity	16	2.32e-01	3.78e-01	0.3310	-2.41e-02	-6.83e-03	0.316000	0.093100	8.68e-01	0.96200	2.86e-02	5.19e-01
XBP1(S) activates chaperone genes	36	2.32e-01	3.78e-01	0.2270	-7.78e-02	2.06e-02	0.212000	0.007170	4.20e-01	0.83000	2.77e-02	9.41e-01
Telomere C-strand synthesis initiation	10	2.33e-01	3.78e-01	0.4440	4.90e-02	2.60e-01	-0.331000	0.132000	7.89e-01	0.15400	7.01e-02	4.71e-01
Intraflagellar transport	31	2.33e-01	3.78e-01	0.2450	9.87e-02	7.33e-02	-0.209000	0.034600	3.42e-01	0.48100	4.47e-02	7.39e-01
Metabolism of porphyrins	15	2.34e-01	3.78e-01	0.3520	-2.82e-01	4.25e-02	0.146000	0.148000	5.91e-02	0.77600	3.28e-01	3.23e-01
Centrosome maturation	64	2.34e-01	3.78e-01	0.1750	1.13e-01	1.11e-01	0.000793	0.074100	1.18e-01	0.12700	9.91e-01	3.06e-01
Recruitment of mitotic centrosome proteins and complexes	64	2.34e-01	3.78e-01	0.1750	1.13e-01	1.11e-01	0.000793	0.074100	1.18e-01	0.12700	9.91e-01	3.06e-01
RAC3 GTPase cycle	59	2.34e-01	3.79e-01	0.1810	-8.42e-04	1.12e-02	0.172000	-0.054000	9.91e-01	0.88200	2.23e-02	4.74e-01
Regulation of PLK1 Activity at G2/M Transition	73	2.35e-01	3.79e-01	0.1590	1.52e-01	-9.36e-03	-0.036500	0.027100	2.47e-02	0.89000	5.91e-01	6.90e-01
Transcriptional Regulation by MECP2	31	2.37e-01	3.81e-01	0.2160	-6.23e-02	-1.03e-01	0.109000	0.142000	5.48e-01	0.32000	2.93e-01	1.70e-01
Apoptotic execution phase	33	2.39e-01	3.84e-01	0.2410	1.74e-01	5.72e-03	0.132000	-0.102000	8.35e-02	0.95500	1.89e-01	3.10e-01
Factors involved in megakaryocyte development and platelet production	86	2.40e-01	3.86e-01	0.1440	6.98e-02	9.19e-02	0.085400	-0.010800	2.65e-01	0.14200	1.72e-01	8.63e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	12	2.45e-01	3.92e-01	0.4090	1.67e-01	2.43e-01	-0.198000	0.203000	3.16e-01	0.14500	2.36e-01	2.25e-01
Signaling by NOTCH2	18	2.46e-01	3.94e-01	0.3060	-1.41e-01	-7.74e-02	0.256000	0.044800	3.00e-01	0.57000	6.02e-02	7.43e-01
RET signaling	22	2.50e-01	3.99e-01	0.2790	-1.78e-01	-5.29e-02	0.206000	0.027200	1.49e-01	0.66800	9.44e-02	8.25e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	54	2.51e-01	4.01e-01	0.1920	-5.26e-02	1.76e-02	-0.134000	0.126000	5.05e-01	0.82300	9.01e-02	1.11e-01
Metabolism of cofactors	17	2.52e-01	4.01e-01	0.3210	2.40e-01	-2.16e-02	0.208000	0.043000	8.71e-02	0.87800	1.39e-01	7.59e-01
Signaling by SCF-KIT	33	2.52e-01	4.01e-01	0.2230	3.88e-02	-1.33e-02	0.201000	0.085900	7.00e-01	0.89500	4.54e-02	3.93e-01
Interleukin-37 signaling	17	2.54e-01	4.03e-01	0.3020	1.27e-02	-2.88e-02	0.232000	0.190000	9.28e-01	0.83700	9.79e-02	1.75e-01
ER Quality Control Compartment (ERQC)	18	2.55e-01	4.05e-01	0.3130	-5.43e-02	-2.73e-01	0.133000	-0.049700	6.90e-01	0.04470	3.28e-01	7.15e-01
Glutathione conjugation	20	2.56e-01	4.05e-01	0.3120	1.38e-01	-3.11e-02	0.214000	-0.177000	2.84e-01	0.81000	9.70e-02	1.70e-01
Synthesis of PIPs at the early endosome membrane	12	2.56e-01	4.06e-01	0.3440	1.18e-01	-1.44e-01	0.171000	0.233000	4.81e-01	0.38900	3.04e-01	1.63e-01
FGFR1 mutant receptor activation	20	2.57e-01	4.06e-01	0.2950	1.18e-01	9.40e-02	0.211000	-0.141000	3.63e-01	0.46700	1.02e-01	2.74e-01
Amyloid fiber formation	24	2.57e-01	4.06e-01	0.2550	-1.15e-01	-7.08e-02	0.198000	0.087900	3.30e-01	0.54900	9.34e-02	4.56e-01
Potential therapeutics for SARS	60	2.61e-01	4.11e-01	0.1640	7.92e-03	9.86e-03	0.073000	0.146000	9.16e-01	0.89500	3.29e-01	5.09e-02
Negative epigenetic regulation of rRNA expression	40	2.65e-01	4.17e-01	0.2160	1.09e-01	4.50e-02	-0.111000	0.142000	2.32e-01	0.62200	2.26e-01	1.20e-01
Frs2-mediated activation	11	2.68e-01	4.21e-01	0.3680	-4.21e-02	-4.69e-02	0.277000	0.234000	8.09e-01	0.78800	1.11e-01	1.79e-01
Nucleobase catabolism	21	2.69e-01	4.23e-01	0.2860	6.62e-02	4.68e-02	0.272000	0.028300	6.00e-01	0.71000	3.08e-02	8.22e-01
RNA Polymerase I Promoter Escape	24	2.70e-01	4.23e-01	0.2750	1.44e-01	6.79e-02	-0.192000	0.116000	2.22e-01	0.56500	1.04e-01	3.25e-01
Beta-catenin phosphorylation cascade	15	2.73e-01	4.27e-01	0.3450	7.25e-02	1.98e-01	0.242000	0.126000	6.27e-01	0.18400	1.05e-01	3.99e-01
Toll Like Receptor 3 (TLR3) Cascade	75	2.75e-01	4.30e-01	0.1460	9.02e-03	-8.06e-03	0.140000	0.041600	8.93e-01	0.90400	3.69e-02	5.34e-01
Disorders of transmembrane transporters	105	2.77e-01	4.33e-01	0.1150	2.23e-02	-3.32e-02	0.037500	0.101000	6.94e-01	0.55800	5.09e-01	7.45e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	2.79e-01	4.35e-01	0.3380	1.71e-01	-6.68e-02	-0.283000	0.018800	2.52e-01	0.65400	5.78e-02	9.00e-01
Regulation of TNFR1 signaling	30	2.81e-01	4.38e-01	0.2250	1.54e-02	-2.21e-01	-0.016500	0.033300	8.84e-01	0.03590	8.76e-01	7.52e-01
Transcriptional regulation of white adipocyte differentiation	55	2.83e-01	4.40e-01	0.1760	1.71e-02	6.19e-02	0.162000	-0.026000	8.27e-01	0.42800	3.84e-02	7.39e-01
Neurexins and neuroligins	19	2.83e-01	4.41e-01	0.2950	-2.54e-01	1.19e-01	-0.086300	-0.029200	5.54e-02	0.36800	5.15e-01	8.26e-01
Interleukin-2 family signaling	29	2.85e-01	4.42e-01	0.2300	-4.53e-02	2.63e-03	0.188000	0.123000	6.73e-01	0.98000	7.96e-02	2.50e-01
MAP kinase activation	50	2.85e-01	4.42e-01	0.1920	-2.00e-02	-6.34e-02	0.160000	-0.083300	8.07e-01	0.43900	5.13e-02	3.09e-01
Dual Incision in GG-NER	35	2.87e-01	4.44e-01	0.2210	7.67e-02	-2.46e-02	-0.200000	0.048500	4.33e-01	0.80200	4.12e-02	6.20e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	14	2.88e-01	4.45e-01	0.3760	-8.29e-02	-2.44e-01	0.077600	-0.263000	5.91e-01	0.11400	6.16e-01	8.82e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	12	2.89e-01	4.46e-01	0.3490	-1.60e-01	-2.17e-01	0.216000	0.048500	3.37e-01	0.19200	1.95e-01	7.71e-01
IRE1alpha activates chaperones	37	2.90e-01	4.48e-01	0.2120	-7.51e-02	3.78e-02	0.192000	0.025500	4.30e-01	0.69100	4.30e-02	7.88e-01
Nuclear Envelope (NE) Reassembly	60	2.91e-01	4.48e-01	0.1640	1.36e-01	-1.46e-02	-0.043400	0.080200	6.93e-02	0.84500	5.62e-01	2.84e-01
Senescence-Associated Secretory Phenotype (SASP)	41	2.92e-01	4.50e-01	0.2000	-1.90e-01	-1.88e-03	0.058900	0.023000	3.57e-02	0.98300	5.15e-01	7.99e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	37	2.93e-01	4.50e-01	0.2170	-7.52e-03	-2.07e-01	-0.040000	-0.047900	9.37e-01	0.02920	6.74e-01	6.15e-01
GAB1 signalosome	10	2.93e-01	4.50e-01	0.4110	-3.20e-01	9.61e-02	0.204000	0.126000	8.02e-02	0.59900	2.63e-01	4.90e-01
Signaling by Hedgehog	97	2.94e-01	4.51e-01	0.1250	4.36e-02	-3.08e-02	0.109000	0.032000	4.60e-01	0.60200	6.54e-02	5.87e-01
Assembly of collagen fibrils and other multimeric structures	14	2.95e-01	4.52e-01	0.3440	-1.22e-01	1.92e-01	0.255000	-0.032300	4.29e-01	0.21300	9.85e-02	8.35e-01
RNA Polymerase III Chain Elongation	16	2.99e-01	4.57e-01	0.3450	-4.70e-02	1.67e-01	-0.236000	0.182000	7.45e-01	0.24800	1.02e-01	2.08e-01
Apoptotic factor-mediated response	15	3.00e-01	4.58e-01	0.3180	5.39e-02	-1.82e-01	0.253000	0.021700	7.18e-01	0.22200	8.94e-02	8.85e-01
ZBP1(DAI) mediated induction of type I IFNs	17	3.03e-01	4.61e-01	0.2880	-1.00e-01	-4.72e-02	0.219000	0.151000	4.74e-01	0.73700	1.18e-01	2.80e-01
PKMTs methylate histone lysines	30	3.03e-01	4.61e-01	0.2090	-7.06e-03	-7.86e-02	0.008010	0.194000	9.47e-01	0.45700	9.40e-01	6.68e-02
HDACs deacetylate histones	28	3.04e-01	4.62e-01	0.2350	-7.67e-02	3.23e-02	0.114000	0.189000	4.83e-01	0.76800	2.97e-01	8.45e-02
RHOBTB1 GTPase cycle	18	3.06e-01	4.64e-01	0.2890	2.18e-01	-2.59e-02	-0.010600	0.187000	1.09e-01	0.84900	9.38e-01	1.69e-01
IRS-mediated signalling	21	3.08e-01	4.65e-01	0.2710	-2.01e-01	-8.04e-02	-0.116000	0.116000	1.12e-01	0.52400	3.59e-01	3.57e-01
Carboxyterminal post-translational modifications of tubulin	22	3.08e-01	4.65e-01	0.2640	-1.78e-02	1.36e-02	0.255000	0.063800	8.85e-01	0.91200	3.83e-02	6.05e-01
IGF1R signaling cascade	23	3.09e-01	4.65e-01	0.2590	-2.24e-01	-7.35e-02	-0.079800	0.073400	6.31e-02	0.54200	5.08e-01	5.43e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	23	3.09e-01	4.65e-01	0.2590	-2.24e-01	-7.35e-02	-0.079800	0.073400	6.31e-02	0.54200	5.08e-01	5.43e-01
Reproduction	43	3.09e-01	4.65e-01	0.1960	9.27e-02	-1.16e-01	-0.128000	-0.006280	2.94e-01	0.19000	1.46e-01	9.43e-01
Role of phospholipids in phagocytosis	16	3.09e-01	4.65e-01	0.3040	-1.47e-01	2.07e-01	0.131000	-0.104000	3.09e-01	0.15100	3.65e-01	4.74e-01
Inactivation, recovery and regulation of the phototransduction cascade	15	3.10e-01	4.65e-01	0.3200	9.72e-02	2.33e-01	-0.194000	0.034100	5.15e-01	0.11900	1.92e-01	8.19e-01
The phototransduction cascade	15	3.10e-01	4.65e-01	0.3200	9.72e-02	2.33e-01	-0.194000	0.034100	5.15e-01	0.11900	1.92e-01	8.19e-01
Cytochrome c-mediated apoptotic response	10	3.11e-01	4.67e-01	0.3910	2.11e-01	-1.38e-01	0.297000	0.035500	2.49e-01	0.45000	1.04e-01	8.46e-01
Diseases associated with N-glycosylation of proteins	15	3.16e-01	4.74e-01	0.2880	2.00e-02	-1.18e-01	0.056000	0.256000	8.93e-01	0.43100	7.08e-01	8.66e-02
CTLA4 inhibitory signaling	16	3.17e-01	4.74e-01	0.2830	-7.69e-02	-1.97e-01	-0.061900	0.177000	5.94e-01	0.17300	6.68e-01	2.20e-01
Glucagon-type ligand receptors	13	3.19e-01	4.77e-01	0.3130	5.61e-02	-8.03e-02	0.110000	0.277000	7.26e-01	0.61600	4.91e-01	8.44e-02
mRNA decay by 3’ to 5’ exoribonuclease	14	3.21e-01	4.79e-01	0.3280	-7.33e-02	-7.85e-02	-0.255000	-0.177000	6.35e-01	0.61100	9.90e-02	2.52e-01
Dual incision in TC-NER	55	3.22e-01	4.80e-01	0.1760	-2.32e-03	1.48e-02	-0.134000	0.114000	9.76e-01	0.85000	8.72e-02	1.45e-01
Cytochrome P450 - arranged by substrate type	14	3.22e-01	4.80e-01	0.3320	2.11e-01	6.70e-02	0.242000	0.046600	1.71e-01	0.66500	1.17e-01	7.63e-01
Cell-Cell communication	46	3.23e-01	4.80e-01	0.1830	-1.53e-01	-9.28e-02	-0.012200	-0.039700	7.38e-02	0.27700	8.86e-01	6.42e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	13	3.23e-01	4.80e-01	0.3430	-3.26e-01	-9.19e-02	-0.019000	-0.054600	4.21e-02	0.56600	9.06e-01	7.33e-01
RNA Polymerase I Transcription Termination	23	3.24e-01	4.80e-01	0.2670	1.30e-01	3.88e-02	-0.184000	0.137000	2.79e-01	0.74800	1.26e-01	2.56e-01
Adrenaline,noradrenaline inhibits insulin secretion	14	3.26e-01	4.82e-01	0.3180	-3.67e-02	2.42e-02	0.204000	0.240000	8.12e-01	0.87500	1.86e-01	1.20e-01
Peroxisomal protein import	48	3.26e-01	4.82e-01	0.1710	1.85e-02	-2.92e-03	0.149000	0.082100	8.25e-01	0.97200	7.41e-02	3.26e-01
Interleukin-15 signaling	12	3.29e-01	4.86e-01	0.3580	-6.57e-02	1.63e-01	0.305000	-0.067100	6.94e-01	0.32900	6.74e-02	6.87e-01
Cytosolic sensors of pathogen-associated DNA	51	3.30e-01	4.86e-01	0.1760	-5.33e-02	4.05e-02	0.046000	0.156000	5.11e-01	0.61700	5.70e-01	5.39e-02
Uptake and actions of bacterial toxins	19	3.31e-01	4.86e-01	0.2650	-8.94e-02	-2.19e-01	0.115000	0.032800	5.00e-01	0.09810	3.86e-01	8.05e-01
Sensory processing of sound	25	3.31e-01	4.86e-01	0.2590	-2.11e-01	8.29e-02	0.027300	0.122000	6.79e-02	0.47300	8.13e-01	2.90e-01
Sensory processing of sound by inner hair cells of the cochlea	25	3.31e-01	4.86e-01	0.2590	-2.11e-01	8.29e-02	0.027300	0.122000	6.79e-02	0.47300	8.13e-01	2.90e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	68	3.31e-01	4.86e-01	0.1560	-5.46e-03	3.32e-03	-0.118000	0.102000	9.38e-01	0.96200	9.27e-02	1.48e-01
Heme signaling	24	3.34e-01	4.89e-01	0.2580	-5.90e-02	2.37e-01	0.074100	0.037600	6.17e-01	0.04440	5.30e-01	7.50e-01
RNA Polymerase III Transcription Initiation	33	3.35e-01	4.90e-01	0.2360	-7.03e-03	1.13e-01	-0.123000	0.167000	9.44e-01	0.26200	2.22e-01	9.78e-02
FCERI mediated NF-kB activation	64	3.37e-01	4.93e-01	0.1420	3.47e-02	-1.61e-02	0.069600	0.118000	6.32e-01	0.82400	3.37e-01	1.03e-01
Trafficking and processing of endosomal TLR	10	3.37e-01	4.93e-01	0.3860	1.75e-02	3.45e-01	0.171000	0.005200	9.24e-01	0.05870	3.48e-01	9.77e-01
NCAM signaling for neurite out-growth	22	3.40e-01	4.95e-01	0.2730	-2.09e-02	-1.53e-01	-0.139000	-0.178000	8.66e-01	0.21400	2.59e-01	1.50e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	19	3.40e-01	4.95e-01	0.2890	1.80e-01	-1.47e-01	-0.167000	-0.037300	1.76e-01	0.26800	2.07e-01	7.79e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	19	3.40e-01	4.95e-01	0.2890	1.80e-01	-1.47e-01	-0.167000	-0.037300	1.76e-01	0.26800	2.07e-01	7.79e-01
Signaling by Retinoic Acid	17	3.40e-01	4.95e-01	0.3100	-5.68e-02	-1.56e-01	-0.127000	-0.228000	6.86e-01	0.26500	3.65e-01	1.04e-01
Interleukin-7 signaling	14	3.41e-01	4.95e-01	0.3530	-1.82e-01	1.82e-01	0.086800	0.225000	2.38e-01	0.23900	5.74e-01	1.46e-01
NOTCH1 Intracellular Domain Regulates Transcription	36	3.43e-01	4.97e-01	0.2020	-7.29e-02	4.01e-02	0.133000	0.127000	4.50e-01	0.67800	1.67e-01	1.88e-01
RHOBTB2 GTPase cycle	19	3.43e-01	4.97e-01	0.2810	2.17e-01	-7.72e-02	-0.152000	0.054800	1.02e-01	0.56000	2.52e-01	6.79e-01
Negative regulation of FGFR1 signaling	17	3.45e-01	4.97e-01	0.3010	-1.89e-01	-1.49e-01	0.149000	-0.104000	1.77e-01	0.28900	2.88e-01	4.60e-01
Negative regulation of FGFR2 signaling	17	3.45e-01	4.97e-01	0.3010	-1.89e-01	-1.49e-01	0.149000	-0.104000	1.77e-01	0.28900	2.88e-01	4.60e-01
Negative regulation of FGFR3 signaling	17	3.45e-01	4.97e-01	0.3010	-1.89e-01	-1.49e-01	0.149000	-0.104000	1.77e-01	0.28900	2.88e-01	4.60e-01
Negative regulation of FGFR4 signaling	17	3.45e-01	4.97e-01	0.3010	-1.89e-01	-1.49e-01	0.149000	-0.104000	1.77e-01	0.28900	2.88e-01	4.60e-01
Ion transport by P-type ATPases	27	3.46e-01	4.97e-01	0.2500	-5.47e-02	-1.42e-01	0.154000	-0.126000	6.23e-01	0.20300	1.67e-01	2.57e-01
APC-Cdc20 mediated degradation of Nek2A	24	3.46e-01	4.97e-01	0.2540	8.41e-02	-1.74e-01	-0.163000	-0.015500	4.76e-01	0.14000	1.67e-01	8.96e-01
Phase II - Conjugation of compounds	44	3.48e-01	4.99e-01	0.1850	6.81e-02	5.75e-03	0.065800	-0.159000	4.35e-01	0.94700	4.50e-01	6.80e-02
Signaling by ERBB2 KD Mutants	11	3.48e-01	4.99e-01	0.3520	1.60e-02	3.04e-01	-0.175000	-0.009920	9.27e-01	0.08060	3.15e-01	9.55e-01
G alpha (s) signalling events	38	3.51e-01	5.02e-01	0.1980	-4.90e-02	6.29e-02	0.174000	0.050600	6.01e-01	0.50300	6.31e-02	5.90e-01
Cyclin D associated events in G1	41	3.52e-01	5.03e-01	0.1940	1.35e-01	-1.27e-01	-0.056900	-0.012100	1.36e-01	0.16000	5.29e-01	8.93e-01
G1 Phase	41	3.52e-01	5.03e-01	0.1940	1.35e-01	-1.27e-01	-0.056900	-0.012100	1.36e-01	0.16000	5.29e-01	8.93e-01
NOTCH4 Intracellular Domain Regulates Transcription	13	3.56e-01	5.07e-01	0.3280	-2.04e-01	-7.70e-03	0.239000	0.091300	2.03e-01	0.96200	1.35e-01	5.69e-01
Formation of the Early Elongation Complex	29	3.56e-01	5.07e-01	0.2440	-8.56e-02	1.51e-01	0.073400	0.154000	4.25e-01	0.15900	4.94e-01	1.52e-01
Formation of the HIV-1 Early Elongation Complex	29	3.56e-01	5.07e-01	0.2440	-8.56e-02	1.51e-01	0.073400	0.154000	4.25e-01	0.15900	4.94e-01	1.52e-01
Signaling by Non-Receptor Tyrosine Kinases	33	3.57e-01	5.07e-01	0.2160	-1.37e-01	8.64e-02	0.128000	0.065900	1.75e-01	0.39100	2.05e-01	5.13e-01
Signaling by PTK6	33	3.57e-01	5.07e-01	0.2160	-1.37e-01	8.64e-02	0.128000	0.065900	1.75e-01	0.39100	2.05e-01	5.13e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	15	3.58e-01	5.07e-01	0.3230	-1.70e-01	-1.33e-01	0.186000	-0.152000	2.56e-01	0.37300	2.11e-01	3.10e-01
Assembly Of The HIV Virion	14	3.59e-01	5.09e-01	0.3240	-2.40e-01	6.08e-02	0.198000	0.064000	1.19e-01	0.69400	1.99e-01	6.79e-01
Mitochondrial Fatty Acid Beta-Oxidation	25	3.60e-01	5.09e-01	0.2350	-2.47e-02	2.33e-01	0.012900	-0.004580	8.31e-01	0.04350	9.11e-01	9.68e-01
Interleukin-6 signaling	10	3.60e-01	5.09e-01	0.3880	1.27e-02	1.58e-01	0.212000	0.284000	9.44e-01	0.38600	2.45e-01	1.20e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	34	3.66e-01	5.16e-01	0.2220	3.56e-02	9.38e-02	-0.133000	0.146000	7.20e-01	0.34500	1.80e-01	1.40e-01
Sensory Perception	61	3.67e-01	5.16e-01	0.1660	-1.15e-01	9.39e-02	-0.023400	0.070100	1.21e-01	0.20500	7.52e-01	3.45e-01
Leading Strand Synthesis	12	3.67e-01	5.16e-01	0.3470	2.09e-01	-5.39e-02	-0.268000	0.046500	2.09e-01	0.74700	1.09e-01	7.80e-01
Polymerase switching	12	3.67e-01	5.16e-01	0.3470	2.09e-01	-5.39e-02	-0.268000	0.046500	2.09e-01	0.74700	1.09e-01	7.80e-01
TRAF3-dependent IRF activation pathway	13	3.69e-01	5.17e-01	0.3310	1.76e-01	1.61e-01	0.227000	0.023300	2.71e-01	0.31600	1.56e-01	8.84e-01
Intra-Golgi traffic	39	3.69e-01	5.18e-01	0.1930	-3.41e-02	2.90e-02	0.185000	-0.032100	7.13e-01	0.75400	4.56e-02	7.29e-01
RHOD GTPase cycle	37	3.71e-01	5.19e-01	0.1970	1.43e-01	5.80e-02	0.028800	0.119000	1.33e-01	0.54200	7.62e-01	2.11e-01
ECM proteoglycans	12	3.71e-01	5.19e-01	0.3110	-1.31e-02	9.03e-02	-0.057100	-0.292000	9.37e-01	0.58800	7.32e-01	8.03e-02
Cargo trafficking to the periciliary membrane	40	3.72e-01	5.19e-01	0.1920	1.75e-01	-3.39e-02	-0.044000	-0.056400	5.62e-02	0.71100	6.31e-01	5.38e-01
Chaperone Mediated Autophagy	12	3.73e-01	5.19e-01	0.3450	-2.23e-01	-1.78e-01	-0.169000	-0.096300	1.82e-01	0.28700	3.12e-01	5.64e-01
Global Genome Nucleotide Excision Repair (GG-NER)	76	3.73e-01	5.19e-01	0.1410	7.88e-02	3.64e-02	-0.082600	0.074600	2.36e-01	0.58400	2.14e-01	2.62e-01
Nucleotide salvage	18	3.74e-01	5.19e-01	0.2750	-1.15e-01	1.21e-01	0.186000	-0.117000	3.99e-01	0.37400	1.73e-01	3.92e-01
ADORA2B mediated anti-inflammatory cytokines production	30	3.74e-01	5.19e-01	0.2200	-4.11e-02	1.01e-01	0.188000	0.034000	6.97e-01	0.33900	7.45e-02	7.47e-01
DCC mediated attractive signaling	11	3.74e-01	5.19e-01	0.3600	1.53e-02	2.89e-01	-0.206000	0.062700	9.30e-01	0.09760	2.37e-01	7.19e-01
Myogenesis	13	3.75e-01	5.20e-01	0.3370	5.81e-02	-1.34e-01	0.295000	-0.073300	7.17e-01	0.40500	6.53e-02	6.47e-01
RIP-mediated NFkB activation via ZBP1	14	3.77e-01	5.22e-01	0.2880	-9.20e-02	-1.08e-01	0.199000	0.152000	5.51e-01	0.48300	1.98e-01	3.25e-01
Fc epsilon receptor (FCERI) signaling	109	3.77e-01	5.22e-01	0.1130	-1.20e-02	2.84e-02	0.077400	0.076200	8.29e-01	0.61000	1.64e-01	1.71e-01
Retinoid metabolism and transport	10	3.81e-01	5.27e-01	0.3690	-1.34e-01	6.46e-02	0.307000	0.143000	4.64e-01	0.72400	9.32e-02	4.35e-01
Heme biosynthesis	10	3.82e-01	5.27e-01	0.3900	-2.77e-01	9.01e-02	-0.007290	0.259000	1.30e-01	0.62200	9.68e-01	1.56e-01
Regulation of RUNX1 Expression and Activity	15	3.82e-01	5.27e-01	0.2780	8.57e-02	-2.40e-01	0.049800	0.099400	5.66e-01	0.10800	7.39e-01	5.05e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	21	3.83e-01	5.28e-01	0.2500	4.55e-02	-5.05e-02	0.237000	0.040700	7.19e-01	0.68900	6.06e-02	7.47e-01
Defects in vitamin and cofactor metabolism	16	3.85e-01	5.29e-01	0.2960	7.26e-02	-7.81e-02	-0.259000	0.096500	6.15e-01	0.58900	7.31e-02	5.04e-01
ATF4 activates genes in response to endoplasmic reticulum stress	23	3.85e-01	5.29e-01	0.2440	1.49e-01	-2.18e-02	-0.073800	-0.177000	2.16e-01	0.85700	5.41e-01	1.43e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	19	3.87e-01	5.31e-01	0.2800	-2.44e-01	1.02e-01	-0.065900	0.065000	6.61e-02	0.44100	6.19e-01	6.24e-01
Circadian Clock	50	3.88e-01	5.32e-01	0.1620	-9.09e-02	1.26e-01	0.030900	-0.031400	2.67e-01	0.12400	7.06e-01	7.02e-01
Signaling by cytosolic FGFR1 fusion mutants	17	3.89e-01	5.33e-01	0.2860	1.64e-01	6.13e-02	0.204000	-0.098600	2.43e-01	0.66200	1.46e-01	4.82e-01
Nephrin family interactions	13	3.90e-01	5.33e-01	0.3250	-1.73e-01	-1.06e-01	-0.249000	0.044600	2.80e-01	0.50800	1.20e-01	7.81e-01
p75NTR signals via NF-kB	11	3.90e-01	5.33e-01	0.3510	-3.36e-01	-6.75e-02	-0.005590	-0.075300	5.37e-02	0.69800	9.74e-01	6.66e-01
TP53 Regulates Transcription of DNA Repair Genes	51	3.91e-01	5.33e-01	0.1760	-9.53e-02	4.29e-02	-0.081400	0.116000	2.40e-01	0.59600	3.16e-01	1.54e-01
Metabolism of vitamins and cofactors	107	3.91e-01	5.33e-01	0.1110	4.28e-02	1.08e-02	0.094100	0.038700	4.46e-01	0.84800	9.36e-02	4.91e-01
Triglyceride metabolism	16	3.91e-01	5.33e-01	0.2750	5.52e-02	1.79e-01	0.144000	-0.141000	7.03e-01	0.21500	3.20e-01	3.30e-01
Estrogen-dependent gene expression	68	3.93e-01	5.34e-01	0.1540	-7.24e-02	5.05e-02	-0.042600	0.118000	3.03e-01	0.47300	5.45e-01	9.19e-02
PERK regulates gene expression	26	3.94e-01	5.34e-01	0.2240	1.76e-01	1.10e-02	-0.109000	-0.084400	1.20e-01	0.92300	3.37e-01	4.57e-01
Diseases of DNA repair	10	3.94e-01	5.35e-01	0.3710	2.22e-01	-2.41e-02	-0.225000	0.193000	2.25e-01	0.89500	2.19e-01	2.90e-01
CLEC7A (Dectin-1) induces NFAT activation	11	3.95e-01	5.35e-01	0.3810	2.30e-02	2.26e-01	-0.220000	0.212000	8.95e-01	0.19400	2.06e-01	2.24e-01
ERKs are inactivated	12	3.98e-01	5.39e-01	0.3380	-2.14e-02	6.24e-02	0.329000	-0.043600	8.98e-01	0.70800	4.86e-02	7.94e-01
Branched-chain amino acid catabolism	19	4.00e-01	5.41e-01	0.2620	2.29e-01	-6.46e-02	-0.067600	0.088300	8.44e-02	0.62600	6.10e-01	5.06e-01
Downregulation of ERBB2 signaling	15	4.05e-01	5.46e-01	0.2980	-2.87e-01	-3.53e-03	0.078400	0.010000	5.45e-02	0.98100	5.99e-01	9.46e-01
Metabolism of fat-soluble vitamins	12	4.05e-01	5.46e-01	0.3470	-1.60e-01	1.76e-01	0.209000	0.141000	3.38e-01	0.29100	2.10e-01	3.98e-01
Class I peroxisomal membrane protein import	19	4.05e-01	5.46e-01	0.2720	1.48e-01	4.86e-02	-0.132000	0.180000	2.65e-01	0.71400	3.19e-01	1.75e-01
InlB-mediated entry of Listeria monocytogenes into host cell	11	4.06e-01	5.46e-01	0.3400	-1.03e-01	4.57e-02	0.273000	0.170000	5.54e-01	0.79300	1.17e-01	3.30e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	28	4.06e-01	5.46e-01	0.2210	1.25e-01	1.60e-01	0.061400	0.061500	2.54e-01	0.14300	5.75e-01	5.74e-01
SLC transporter disorders	49	4.11e-01	5.52e-01	0.1640	3.57e-02	-4.86e-02	-0.135000	0.072400	6.66e-01	0.55700	1.03e-01	3.81e-01
Inhibition of DNA recombination at telomere	16	4.11e-01	5.52e-01	0.3140	-1.76e-01	1.31e-01	-0.084500	0.207000	2.22e-01	0.36600	5.59e-01	1.51e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	22	4.12e-01	5.52e-01	0.2720	5.82e-02	-2.00e-01	-0.015900	-0.174000	6.37e-01	0.10500	8.97e-01	1.59e-01
Inwardly rectifying K+ channels	12	4.13e-01	5.52e-01	0.3050	5.87e-02	-5.08e-02	0.213000	0.203000	7.25e-01	0.76100	2.02e-01	2.22e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	13	4.14e-01	5.54e-01	0.3240	-1.26e-01	8.40e-02	0.107000	0.265000	4.30e-01	0.60000	5.03e-01	9.84e-02
Synthesis of PIPs at the plasma membrane	36	4.16e-01	5.55e-01	0.1940	-1.03e-01	-1.08e-02	0.142000	-0.083000	2.86e-01	0.91100	1.41e-01	3.89e-01
RAF-independent MAPK1/3 activation	20	4.18e-01	5.57e-01	0.2440	-1.49e-01	-2.11e-02	0.091700	0.169000	2.49e-01	0.87000	4.78e-01	1.92e-01
Citric acid cycle (TCA cycle)	19	4.20e-01	5.59e-01	0.2570	6.98e-02	6.26e-02	0.172000	0.166000	5.99e-01	0.63700	1.95e-01	2.10e-01
Purine catabolism	10	4.21e-01	5.59e-01	0.3620	-5.16e-02	2.24e-01	0.279000	-0.011600	7.78e-01	0.22000	1.26e-01	9.49e-01
Telomere Extension By Telomerase	20	4.21e-01	5.59e-01	0.2750	-3.91e-02	1.57e-01	-0.179000	0.132000	7.62e-01	0.22600	1.67e-01	3.06e-01
VEGFR2 mediated vascular permeability	22	4.22e-01	5.60e-01	0.2540	-3.91e-02	2.06e-01	0.120000	0.080000	7.51e-01	0.09490	3.29e-01	5.16e-01
Sialic acid metabolism	23	4.25e-01	5.63e-01	0.2450	8.67e-02	-4.00e-02	0.211000	-0.081300	4.72e-01	0.74000	8.00e-02	5.00e-01
Cell-cell junction organization	12	4.29e-01	5.66e-01	0.3130	3.43e-02	-1.16e-02	-0.101000	-0.294000	8.37e-01	0.94500	5.44e-01	7.81e-02
Nucleotide Excision Repair	98	4.29e-01	5.66e-01	0.1200	1.11e-02	1.48e-02	-0.085300	0.082400	8.50e-01	0.80100	1.46e-01	1.60e-01
Signaling by WNT in cancer	22	4.29e-01	5.66e-01	0.2430	9.37e-03	2.34e-01	0.054500	0.030200	9.39e-01	0.05730	6.58e-01	8.06e-01
PKA activation	10	4.29e-01	5.66e-01	0.3400	-2.14e-01	1.47e-01	0.106000	-0.193000	2.41e-01	0.42200	5.63e-01	2.91e-01
The NLRP3 inflammasome	12	4.33e-01	5.70e-01	0.3180	1.27e-01	-9.51e-02	0.274000	0.030600	4.48e-01	0.56800	1.00e-01	8.54e-01
Apoptotic cleavage of cellular proteins	25	4.33e-01	5.70e-01	0.2310	1.37e-01	4.28e-03	0.167000	-0.083200	2.37e-01	0.97000	1.50e-01	4.72e-01
Signaling by TGFB family members	73	4.35e-01	5.71e-01	0.1170	-1.15e-02	-8.65e-02	0.059100	0.051100	8.65e-01	0.20200	3.83e-01	4.52e-01
NoRC negatively regulates rRNA expression	39	4.36e-01	5.71e-01	0.1850	9.46e-02	2.95e-02	-0.094500	0.124000	3.07e-01	0.75000	3.08e-01	1.80e-01
Initiation of Nuclear Envelope (NE) Reformation	17	4.38e-01	5.71e-01	0.2780	2.42e-01	-7.74e-02	0.107000	-0.037700	8.45e-02	0.58100	4.45e-01	7.88e-01
HIV Transcription Initiation	37	4.38e-01	5.71e-01	0.1770	1.39e-01	-2.17e-02	0.065400	0.085200	1.44e-01	0.82000	4.92e-01	3.70e-01
RNA Polymerase II HIV Promoter Escape	37	4.38e-01	5.71e-01	0.1770	1.39e-01	-2.17e-02	0.065400	0.085200	1.44e-01	0.82000	4.92e-01	3.70e-01
RNA Polymerase II Promoter Escape	37	4.38e-01	5.71e-01	0.1770	1.39e-01	-2.17e-02	0.065400	0.085200	1.44e-01	0.82000	4.92e-01	3.70e-01
RNA Polymerase II Transcription Initiation	37	4.38e-01	5.71e-01	0.1770	1.39e-01	-2.17e-02	0.065400	0.085200	1.44e-01	0.82000	4.92e-01	3.70e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	37	4.38e-01	5.71e-01	0.1770	1.39e-01	-2.17e-02	0.065400	0.085200	1.44e-01	0.82000	4.92e-01	3.70e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	37	4.38e-01	5.71e-01	0.1770	1.39e-01	-2.17e-02	0.065400	0.085200	1.44e-01	0.82000	4.92e-01	3.70e-01
Maturation of nucleoprotein	10	4.39e-01	5.71e-01	0.3350	2.33e-01	-1.93e-01	0.098000	0.107000	2.03e-01	0.29100	5.92e-01	5.59e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	61	4.41e-01	5.74e-01	0.1450	1.24e-01	-1.14e-02	0.073100	-0.017000	9.51e-02	0.87700	3.24e-01	8.19e-01
FCERI mediated Ca+2 mobilization	25	4.42e-01	5.74e-01	0.2230	-4.72e-02	2.17e-01	0.006600	0.011000	6.83e-01	0.06050	9.54e-01	9.24e-01
Diseases associated with glycosylation precursor biosynthesis	18	4.45e-01	5.77e-01	0.2630	7.04e-02	8.55e-02	0.237000	-0.028800	6.06e-01	0.53000	8.17e-02	8.32e-01
Interleukin-12 family signaling	41	4.46e-01	5.77e-01	0.1810	9.93e-02	9.78e-02	0.004500	0.116000	2.72e-01	0.27900	9.60e-01	2.00e-01
Selective autophagy	48	4.46e-01	5.77e-01	0.1590	-6.67e-02	-2.77e-03	0.042500	-0.138000	4.25e-01	0.97400	6.11e-01	9.75e-02
Inactivation of CSF3 (G-CSF) signaling	19	4.46e-01	5.77e-01	0.2450	-3.64e-02	-3.59e-02	0.229000	0.067100	7.84e-01	0.78600	8.35e-02	6.13e-01
Suppression of phagosomal maturation	12	4.47e-01	5.78e-01	0.2930	-6.72e-02	-1.74e-01	0.207000	0.091100	6.87e-01	0.29700	2.14e-01	5.85e-01
Role of LAT2/NTAL/LAB on calcium mobilization	11	4.50e-01	5.81e-01	0.3380	-1.21e-01	4.90e-02	0.295000	-0.099300	4.88e-01	0.77900	9.02e-02	5.69e-01
Synthesis of glycosylphosphatidylinositol (GPI)	13	4.51e-01	5.81e-01	0.3050	1.20e-01	2.70e-01	-0.054500	0.049800	4.53e-01	0.09180	7.34e-01	7.56e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	32	4.52e-01	5.81e-01	0.1870	-1.29e-01	-6.73e-02	0.113000	0.032300	2.06e-01	0.51100	2.71e-01	7.52e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	22	4.56e-01	5.86e-01	0.2340	-2.06e-01	9.31e-02	-0.059000	-0.019600	9.52e-02	0.45000	6.32e-01	8.73e-01
Formation of HIV elongation complex in the absence of HIV Tat	36	4.62e-01	5.94e-01	0.1960	-1.00e-01	7.82e-02	0.006740	0.150000	2.99e-01	0.41700	9.44e-01	1.21e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	4.64e-01	5.96e-01	0.2810	2.63e-02	-1.60e-01	-0.211000	-0.089000	8.56e-01	0.26800	1.44e-01	5.38e-01
Basigin interactions	14	4.71e-01	6.04e-01	0.2910	-2.29e-01	-1.47e-01	-0.057400	-0.084500	1.38e-01	0.34100	7.10e-01	5.84e-01
Retrograde transport at the Trans-Golgi-Network	45	4.76e-01	6.09e-01	0.1690	6.85e-02	-3.19e-02	0.137000	-0.064400	4.27e-01	0.71200	1.14e-01	4.55e-01
PKA-mediated phosphorylation of CREB	11	4.79e-01	6.12e-01	0.3010	-1.46e-01	1.58e-01	0.066800	-0.199000	4.03e-01	0.36400	7.01e-01	2.53e-01
Signaling by TGF-beta Receptor Complex	63	4.83e-01	6.16e-01	0.1290	-5.49e-02	-1.15e-01	0.011800	0.009450	4.52e-01	0.11400	8.72e-01	8.97e-01
Pre-NOTCH Transcription and Translation	27	4.83e-01	6.16e-01	0.1990	-4.12e-02	6.37e-03	0.166000	0.101000	7.11e-01	0.95400	1.35e-01	3.66e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	33	4.84e-01	6.17e-01	0.2010	-1.28e-01	1.33e-01	0.020500	0.077800	2.04e-01	0.18800	8.38e-01	4.40e-01
Fatty acyl-CoA biosynthesis	26	4.85e-01	6.17e-01	0.2090	4.55e-02	2.94e-02	0.013600	0.201000	6.88e-01	0.79600	9.05e-01	7.59e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter	25	4.87e-01	6.19e-01	0.2320	3.19e-02	1.01e-01	-0.116000	0.171000	7.83e-01	0.38200	3.14e-01	1.39e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	13	4.89e-01	6.21e-01	0.2780	-1.51e-01	-4.23e-02	0.136000	0.185000	3.48e-01	0.79200	3.95e-01	2.48e-01
Protein-protein interactions at synapses	31	4.90e-01	6.22e-01	0.1900	-1.45e-01	-2.14e-02	0.009200	-0.121000	1.63e-01	0.83700	9.29e-01	2.45e-01
Interleukin-6 family signaling	12	4.92e-01	6.23e-01	0.3180	-1.02e-01	1.46e-01	0.197000	0.176000	5.40e-01	0.38200	2.38e-01	2.92e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	35	4.93e-01	6.23e-01	0.1960	-1.15e-01	9.07e-02	-0.005710	0.130000	2.38e-01	0.35400	9.53e-01	1.85e-01
HIV Transcription Elongation	35	4.93e-01	6.23e-01	0.1960	-1.15e-01	9.07e-02	-0.005710	0.130000	2.38e-01	0.35400	9.53e-01	1.85e-01
Tat-mediated elongation of the HIV-1 transcript	35	4.93e-01	6.23e-01	0.1960	-1.15e-01	9.07e-02	-0.005710	0.130000	2.38e-01	0.35400	9.53e-01	1.85e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	11	4.93e-01	6.23e-01	0.3240	-1.51e-01	1.02e-01	0.265000	0.038200	3.86e-01	0.55700	1.28e-01	8.27e-01
Glycogen metabolism	17	4.95e-01	6.24e-01	0.2640	-1.59e-01	-1.39e-01	0.121000	-0.103000	2.57e-01	0.32300	3.88e-01	4.62e-01
Negative regulators of DDX58/IFIH1 signaling	33	4.96e-01	6.24e-01	0.1780	9.69e-02	-1.21e-01	-0.064600	0.059500	3.36e-01	0.23100	5.21e-01	5.55e-01
Purine salvage	11	4.97e-01	6.25e-01	0.3160	-9.92e-03	3.11e-01	0.053200	0.012300	9.55e-01	0.07390	7.60e-01	9.44e-01
Triglyceride catabolism	11	4.97e-01	6.25e-01	0.3210	1.40e-01	8.34e-02	0.258000	-0.099400	4.22e-01	0.63200	1.38e-01	5.68e-01
Inflammasomes	16	5.06e-01	6.34e-01	0.2470	1.28e-01	-1.07e-01	0.164000	0.079300	3.76e-01	0.45800	2.55e-01	5.83e-01
MAPK targets/ Nuclear events mediated by MAP kinases	24	5.06e-01	6.34e-01	0.2150	-3.81e-02	8.22e-02	0.184000	-0.063800	7.47e-01	0.48600	1.19e-01	5.89e-01
Regulation of TP53 Expression and Degradation	33	5.07e-01	6.36e-01	0.1830	-1.67e-02	-9.61e-02	-0.153000	0.023400	8.68e-01	0.34000	1.30e-01	8.16e-01
Signaling by ERBB4	31	5.09e-01	6.37e-01	0.1930	-7.88e-02	-9.62e-02	0.132000	-0.066200	4.48e-01	0.35500	2.02e-01	5.24e-01
Keratan sulfate biosynthesis	15	5.11e-01	6.38e-01	0.2820	-2.27e-01	1.51e-01	0.037900	0.064800	1.28e-01	0.31300	7.99e-01	6.64e-01
Zinc transporters	11	5.20e-01	6.49e-01	0.3480	1.31e-01	-2.25e-01	0.021300	-0.230000	4.50e-01	0.19600	9.03e-01	1.87e-01
Polo-like kinase mediated events	14	5.21e-01	6.49e-01	0.2760	2.40e-01	-2.96e-02	-0.108000	0.077000	1.20e-01	0.84800	4.83e-01	6.18e-01
Transcriptional regulation of granulopoiesis	24	5.21e-01	6.49e-01	0.2180	1.29e-01	-3.56e-03	0.154000	-0.084400	2.74e-01	0.97600	1.92e-01	4.74e-01
Downregulation of TGF-beta receptor signaling	26	5.22e-01	6.49e-01	0.1920	-7.54e-02	-1.30e-01	-0.093900	0.074900	5.06e-01	0.25200	4.07e-01	5.09e-01
Signaling by ERBB2 ECD mutants	10	5.22e-01	6.49e-01	0.3290	9.66e-02	2.41e-01	-0.190000	0.067800	5.97e-01	0.18800	2.98e-01	7.11e-01
Effects of PIP2 hydrolysis	19	5.25e-01	6.52e-01	0.2500	-1.86e-01	8.62e-02	-0.110000	0.091000	1.60e-01	0.51600	4.08e-01	4.92e-01
RUNX3 regulates NOTCH signaling	11	5.29e-01	6.56e-01	0.3130	-2.09e-01	6.49e-02	0.154000	0.161000	2.30e-01	0.70900	3.75e-01	3.54e-01
RNA Polymerase II Pre-transcription Events	65	5.37e-01	6.66e-01	0.1250	7.05e-02	2.50e-02	0.036000	0.093500	3.27e-01	0.72800	6.17e-01	1.93e-01
RUNX2 regulates bone development	16	5.41e-01	6.70e-01	0.2460	1.04e-02	-7.43e-02	0.233000	0.025600	9.43e-01	0.60700	1.06e-01	8.60e-01
HCMV Late Events	51	5.42e-01	6.70e-01	0.1470	1.69e-02	2.35e-02	-0.044100	0.137000	8.35e-01	0.77200	5.86e-01	9.10e-02
Response of EIF2AK1 (HRI) to heme deficiency	13	5.44e-01	6.71e-01	0.2900	2.33e-01	-1.41e-01	0.089500	-0.041400	1.46e-01	0.37800	5.77e-01	7.96e-01
Ca-dependent events	21	5.44e-01	6.71e-01	0.2260	-1.20e-01	1.37e-01	0.132000	0.014800	3.43e-01	0.27600	2.94e-01	9.06e-01
Cell junction organization	25	5.45e-01	6.72e-01	0.2030	-1.73e-01	-7.08e-02	0.000743	-0.080200	1.35e-01	0.54100	9.95e-01	4.88e-01
FGFR2 mutant receptor activation	15	5.47e-01	6.73e-01	0.2830	-1.36e-01	9.92e-02	-0.079400	0.214000	3.62e-01	0.50600	5.94e-01	1.52e-01
Transport of vitamins, nucleosides, and related molecules	21	5.48e-01	6.74e-01	0.2120	-8.77e-02	1.59e-01	0.090700	-0.062300	4.87e-01	0.20800	4.72e-01	6.22e-01
Glycogen synthesis	11	5.49e-01	6.74e-01	0.3040	-2.68e-01	6.72e-02	0.115000	-0.054200	1.24e-01	0.70000	5.10e-01	7.56e-01
Vasopressin regulates renal water homeostasis via Aquaporins	21	5.49e-01	6.74e-01	0.2180	-5.91e-02	3.23e-02	0.201000	0.051100	6.39e-01	0.79800	1.11e-01	6.86e-01
Protein localization	122	5.51e-01	6.75e-01	0.0906	-6.28e-03	-2.54e-03	-0.021100	0.087800	9.05e-01	0.96100	6.88e-01	9.52e-02
Synthesis of PA	18	5.53e-01	6.77e-01	0.2150	-2.73e-02	4.39e-02	-0.081100	-0.193000	8.41e-01	0.74700	5.52e-01	1.57e-01
Ion homeostasis	26	5.55e-01	6.79e-01	0.2020	-1.34e-01	-1.19e-01	0.028300	-0.088400	2.37e-01	0.29500	8.03e-01	4.36e-01
Dopamine Neurotransmitter Release Cycle	12	5.56e-01	6.80e-01	0.2850	-1.76e-01	1.70e-01	-0.145000	-0.016600	2.92e-01	0.30900	3.85e-01	9.21e-01
Regulation of TP53 Degradation	32	5.59e-01	6.82e-01	0.1740	-3.21e-02	-1.01e-01	-0.134000	0.034300	7.53e-01	0.32300	1.90e-01	7.37e-01
Diseases of metabolism	120	5.59e-01	6.82e-01	0.0914	-6.04e-02	7.05e-03	0.067800	0.006810	2.55e-01	0.89400	2.01e-01	8.98e-01
mRNA Splicing - Minor Pathway	44	5.61e-01	6.83e-01	0.1590	-6.22e-02	2.81e-02	-0.117000	0.083800	4.76e-01	0.74700	1.82e-01	3.37e-01
Signaling by FGFR2 IIIa TM	14	5.61e-01	6.83e-01	0.2770	-8.91e-02	6.09e-02	-0.023200	0.254000	5.64e-01	0.69300	8.81e-01	9.98e-02
E3 ubiquitin ligases ubiquitinate target proteins	41	5.63e-01	6.84e-01	0.1480	6.65e-02	5.50e-03	0.069500	0.112000	4.62e-01	0.95200	4.42e-01	2.13e-01
Phosphorylation of the APC/C	18	5.64e-01	6.85e-01	0.2370	1.82e-01	-1.38e-01	-0.063700	0.005000	1.82e-01	0.31200	6.40e-01	9.71e-01
Class B/2 (Secretin family receptors)	26	5.66e-01	6.87e-01	0.2050	-1.08e-01	9.44e-02	0.080400	0.123000	3.41e-01	0.40500	4.78e-01	2.78e-01
Sulfur amino acid metabolism	15	5.77e-01	6.99e-01	0.2630	-1.99e-01	3.39e-02	-0.122000	0.117000	1.82e-01	0.82000	4.13e-01	4.33e-01
Formation of RNA Pol II elongation complex	48	5.79e-01	6.99e-01	0.1520	-2.93e-02	7.25e-02	0.030700	0.126000	7.26e-01	0.38600	7.13e-01	1.31e-01
RNA Polymerase II Transcription Elongation	48	5.79e-01	6.99e-01	0.1520	-2.93e-02	7.25e-02	0.030700	0.126000	7.26e-01	0.38600	7.13e-01	1.31e-01
Caspase activation via Death Receptors in the presence of ligand	10	5.79e-01	6.99e-01	0.3210	1.97e-01	-2.08e-01	0.133000	-0.059300	2.82e-01	0.25600	4.68e-01	7.46e-01
Diseases of glycosylation	68	5.81e-01	6.99e-01	0.1220	-7.63e-02	4.42e-02	0.068100	0.049700	2.78e-01	0.52900	3.32e-01	4.80e-01
CaM pathway	20	5.81e-01	6.99e-01	0.2180	-1.19e-01	1.55e-01	0.093200	-0.021700	3.58e-01	0.22900	4.71e-01	8.67e-01
Calmodulin induced events	20	5.81e-01	6.99e-01	0.2180	-1.19e-01	1.55e-01	0.093200	-0.021700	3.58e-01	0.22900	4.71e-01	8.67e-01
Membrane binding and targetting of GAG proteins	12	5.82e-01	6.99e-01	0.2810	-1.95e-01	-4.40e-02	0.193000	-0.041300	2.42e-01	0.79200	2.47e-01	8.05e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	12	5.82e-01	6.99e-01	0.2810	-1.95e-01	-4.40e-02	0.193000	-0.041300	2.42e-01	0.79200	2.47e-01	8.05e-01
Interconversion of nucleotide di- and triphosphates	22	5.87e-01	7.04e-01	0.2040	5.28e-02	-1.33e-01	-0.140000	0.041200	6.68e-01	0.28000	2.56e-01	7.38e-01
Listeria monocytogenes entry into host cells	14	5.87e-01	7.04e-01	0.2550	-7.15e-03	9.11e-03	0.252000	0.040300	9.63e-01	0.95300	1.03e-01	7.94e-01
mRNA Capping	25	5.91e-01	7.08e-01	0.1980	6.25e-02	5.21e-02	-0.001520	0.180000	5.89e-01	0.65200	9.90e-01	1.19e-01
Signaling by ERBB2 in Cancer	12	5.96e-01	7.12e-01	0.2520	2.75e-02	2.00e-01	-0.130000	-0.074300	8.69e-01	0.23000	4.35e-01	6.56e-01
S33 mutants of beta-catenin aren’t phosphorylated	13	5.99e-01	7.12e-01	0.2660	1.77e-01	1.14e-01	0.147000	0.069400	2.70e-01	0.47700	3.60e-01	6.65e-01
S37 mutants of beta-catenin aren’t phosphorylated	13	5.99e-01	7.12e-01	0.2660	1.77e-01	1.14e-01	0.147000	0.069400	2.70e-01	0.47700	3.60e-01	6.65e-01
S45 mutants of beta-catenin aren’t phosphorylated	13	5.99e-01	7.12e-01	0.2660	1.77e-01	1.14e-01	0.147000	0.069400	2.70e-01	0.47700	3.60e-01	6.65e-01
Signaling by CTNNB1 phospho-site mutants	13	5.99e-01	7.12e-01	0.2660	1.77e-01	1.14e-01	0.147000	0.069400	2.70e-01	0.47700	3.60e-01	6.65e-01
Signaling by GSK3beta mutants	13	5.99e-01	7.12e-01	0.2660	1.77e-01	1.14e-01	0.147000	0.069400	2.70e-01	0.47700	3.60e-01	6.65e-01
T41 mutants of beta-catenin aren’t phosphorylated	13	5.99e-01	7.12e-01	0.2660	1.77e-01	1.14e-01	0.147000	0.069400	2.70e-01	0.47700	3.60e-01	6.65e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	10	6.01e-01	7.13e-01	0.3040	-2.61e-01	-2.25e-02	-0.151000	0.024700	1.53e-01	0.90200	4.08e-01	8.92e-01
Aquaporin-mediated transport	22	6.01e-01	7.13e-01	0.2040	-8.88e-02	3.60e-02	0.177000	0.030100	4.71e-01	0.77000	1.50e-01	8.07e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	23	6.03e-01	7.14e-01	0.1990	1.32e-01	6.20e-02	0.134000	-0.001830	2.72e-01	0.60700	2.65e-01	9.88e-01
Synthesis of substrates in N-glycan biosythesis	48	6.03e-01	7.14e-01	0.1400	8.55e-02	1.93e-02	0.098300	-0.047000	3.06e-01	0.81700	2.40e-01	5.74e-01
Kinesins	31	6.06e-01	7.16e-01	0.1680	1.25e-01	1.03e-01	-0.039200	0.019800	2.29e-01	0.32000	7.06e-01	8.49e-01
CD28 co-stimulation	27	6.06e-01	7.16e-01	0.1880	-1.23e-01	3.74e-02	0.029100	0.134000	2.67e-01	0.73700	7.94e-01	2.30e-01
SUMOylation of transcription cofactors	35	6.07e-01	7.16e-01	0.1630	-1.32e-01	9.45e-02	0.020600	0.003050	1.78e-01	0.33400	8.33e-01	9.75e-01
Transcription of the HIV genome	55	6.07e-01	7.16e-01	0.1250	6.63e-02	5.33e-03	0.011400	0.105000	3.96e-01	0.94600	8.84e-01	1.80e-01
Signaling by PDGFR in disease	16	6.08e-01	7.17e-01	0.2400	1.90e-01	8.40e-02	-0.042300	0.114000	1.89e-01	0.56100	7.70e-01	4.31e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	57	6.10e-01	7.18e-01	0.1210	9.50e-02	-6.38e-02	0.001050	0.039400	2.16e-01	0.40600	9.89e-01	6.07e-01
Netrin-1 signaling	25	6.12e-01	7.20e-01	0.1910	2.61e-02	1.34e-01	-0.128000	0.037600	8.21e-01	0.24600	2.70e-01	7.45e-01
N-Glycan antennae elongation	11	6.13e-01	7.21e-01	0.2880	-2.81e-01	3.48e-02	-0.040800	0.029300	1.06e-01	0.84200	8.15e-01	8.67e-01
Regulation of pyruvate dehydrogenase (PDH) complex	11	6.17e-01	7.24e-01	0.2840	2.44e-01	4.88e-02	-0.109000	0.081800	1.61e-01	0.77900	5.30e-01	6.39e-01
HDMs demethylate histones	13	6.18e-01	7.24e-01	0.2700	-1.06e-01	-3.93e-02	0.174000	-0.173000	5.10e-01	0.80600	2.78e-01	2.82e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR)	32	6.20e-01	7.26e-01	0.1590	4.63e-02	-3.77e-02	0.143000	0.037600	6.51e-01	0.71300	1.63e-01	7.13e-01
RAS processing	15	6.23e-01	7.28e-01	0.2370	-9.14e-02	-5.77e-02	-0.174000	-0.119000	5.40e-01	0.69900	2.42e-01	4.23e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	12	6.23e-01	7.28e-01	0.2590	-1.75e-01	-4.90e-02	0.171000	0.071000	2.95e-01	0.76900	3.05e-01	6.70e-01
Trafficking of AMPA receptors	12	6.23e-01	7.28e-01	0.2590	-1.75e-01	-4.90e-02	0.171000	0.071000	2.95e-01	0.76900	3.05e-01	6.70e-01
Constitutive Signaling by EGFRvIII	10	6.25e-01	7.28e-01	0.2830	1.56e-01	2.35e-01	-0.030700	-0.000108	3.95e-01	0.19900	8.67e-01	1.00e+00
Signaling by EGFRvIII in Cancer	10	6.25e-01	7.28e-01	0.2830	1.56e-01	2.35e-01	-0.030700	-0.000108	3.95e-01	0.19900	8.67e-01	1.00e+00
Molecules associated with elastic fibres	12	6.28e-01	7.31e-01	0.2870	-2.05e-02	-1.77e-01	-0.095200	-0.203000	9.02e-01	0.28900	5.68e-01	2.23e-01
Regulation of BACH1 activity	11	6.30e-01	7.33e-01	0.2930	-1.80e-02	-2.10e-01	-0.158000	-0.128000	9.18e-01	0.22800	3.65e-01	4.62e-01
HCMV Infection	71	6.31e-01	7.34e-01	0.1050	4.17e-02	-1.84e-02	-0.018800	0.092600	5.44e-01	0.78900	7.85e-01	1.78e-01
Diseases associated with O-glycosylation of proteins	21	6.32e-01	7.34e-01	0.2070	-1.33e-01	-9.26e-02	-0.012600	-0.128000	2.91e-01	0.46300	9.21e-01	3.09e-01
DARPP-32 events	20	6.35e-01	7.35e-01	0.2190	8.86e-02	-6.98e-02	0.163000	-0.091800	4.93e-01	0.58900	2.06e-01	4.78e-01
RND2 GTPase cycle	32	6.35e-01	7.35e-01	0.1520	-3.48e-02	1.40e-01	0.018400	-0.045100	7.34e-01	0.17200	8.57e-01	6.59e-01
Signaling by EGFR in Cancer	16	6.37e-01	7.37e-01	0.2250	-1.19e-01	1.89e-01	-0.017500	-0.019300	4.09e-01	0.19000	9.04e-01	8.93e-01
Formation of TC-NER Pre-Incision Complex	45	6.42e-01	7.42e-01	0.1350	-4.81e-03	-2.16e-02	-0.067700	0.115000	9.56e-01	0.80200	4.33e-01	1.84e-01
DNA Damage/Telomere Stress Induced Senescence	23	6.44e-01	7.44e-01	0.2010	4.64e-02	1.47e-01	-0.093900	0.089200	7.00e-01	0.22200	4.36e-01	4.59e-01
Glyoxylate metabolism and glycine degradation	19	6.45e-01	7.44e-01	0.2080	1.62e-01	8.21e-03	-0.050000	0.121000	2.23e-01	0.95100	7.06e-01	3.62e-01
PRC2 methylates histones and DNA	11	6.59e-01	7.59e-01	0.2610	4.83e-02	6.72e-02	-0.245000	-0.038100	7.81e-01	0.70000	1.60e-01	8.27e-01
PI Metabolism	59	6.59e-01	7.59e-01	0.1180	-3.89e-02	8.00e-03	0.109000	-0.024800	6.06e-01	0.91500	1.49e-01	7.43e-01
Meiotic synapsis	23	6.63e-01	7.63e-01	0.1900	3.44e-02	-1.13e-01	-0.146000	-0.028300	7.75e-01	0.34800	2.25e-01	8.14e-01
NRIF signals cell death from the nucleus	14	6.65e-01	7.64e-01	0.2370	-2.00e-01	-1.09e-01	0.041400	-0.053600	1.96e-01	0.48000	7.89e-01	7.29e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	6.66e-01	7.64e-01	0.2350	1.65e-02	-1.46e-01	-0.127000	-0.132000	9.09e-01	0.31300	3.78e-01	3.63e-01
APC/C:Cdc20 mediated degradation of Cyclin B	22	6.66e-01	7.64e-01	0.1910	5.03e-02	-1.51e-01	-0.107000	-0.002240	6.83e-01	0.22100	3.87e-01	9.86e-01
FGFR2 alternative splicing	21	6.66e-01	7.64e-01	0.2090	-5.46e-02	6.99e-02	-0.044900	0.184000	6.65e-01	0.57900	7.22e-01	1.44e-01
Termination of O-glycan biosynthesis	10	6.71e-01	7.68e-01	0.2700	-1.88e-01	-3.38e-02	0.166000	0.092800	3.04e-01	0.85300	3.62e-01	6.12e-01
RNA Polymerase III Abortive And Retractive Initiation	37	6.73e-01	7.68e-01	0.1560	1.68e-02	5.13e-02	-0.092700	0.114000	8.60e-01	0.58900	3.30e-01	2.33e-01
RNA Polymerase III Transcription	37	6.73e-01	7.68e-01	0.1560	1.68e-02	5.13e-02	-0.092700	0.114000	8.60e-01	0.58900	3.30e-01	2.33e-01
HSF1 activation	21	6.73e-01	7.68e-01	0.1930	-9.41e-02	-6.50e-02	-0.150000	0.037800	4.56e-01	0.60600	2.34e-01	7.65e-01
RND3 GTPase cycle	28	6.75e-01	7.70e-01	0.1740	-1.40e-02	1.46e-01	0.077700	0.055100	8.98e-01	0.18300	4.77e-01	6.14e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	22	6.76e-01	7.71e-01	0.1960	6.75e-02	1.10e-01	0.066900	0.131000	5.84e-01	0.37200	5.87e-01	2.88e-01
Negative regulation of MAPK pathway	36	6.86e-01	7.81e-01	0.1310	-1.55e-02	-6.27e-02	0.093500	0.064400	8.72e-01	0.51600	3.32e-01	5.04e-01
Glutamate Neurotransmitter Release Cycle	11	6.91e-01	7.85e-01	0.2690	-7.67e-03	-1.46e-01	-0.174000	-0.144000	9.65e-01	0.40100	3.18e-01	4.08e-01
DAP12 interactions	23	6.94e-01	7.89e-01	0.1720	-1.38e-02	1.40e-01	0.088400	-0.046300	9.09e-01	0.24600	4.63e-01	7.01e-01
Intrinsic Pathway for Apoptosis	46	6.98e-01	7.92e-01	0.1160	-2.31e-03	-5.34e-02	0.092400	0.045000	9.78e-01	0.53100	2.79e-01	5.98e-01
Phase I - Functionalization of compounds	30	6.98e-01	7.92e-01	0.1430	2.67e-02	6.59e-02	0.027300	-0.121000	8.01e-01	0.53300	7.96e-01	2.54e-01
Regulation of KIT signaling	11	7.01e-01	7.94e-01	0.2470	-9.42e-02	-1.17e-02	0.046100	0.223000	5.89e-01	0.94700	7.91e-01	2.00e-01
Non-integrin membrane-ECM interactions	14	7.03e-01	7.95e-01	0.2250	-2.13e-01	1.68e-02	-0.057900	-0.043200	1.68e-01	0.91300	7.08e-01	7.80e-01
RUNX3 regulates p14-ARF	10	7.04e-01	7.96e-01	0.2440	-6.66e-02	-6.37e-02	0.127000	0.187000	7.16e-01	0.72800	4.88e-01	3.07e-01
Transcriptional activation of mitochondrial biogenesis	36	7.06e-01	7.97e-01	0.1280	-6.40e-02	7.70e-02	-0.036300	-0.070800	5.07e-01	0.42400	7.06e-01	4.63e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	13	7.09e-01	8.00e-01	0.2280	-6.65e-02	-1.47e-01	-0.149000	0.059700	6.78e-01	0.36000	3.51e-01	7.10e-01
Mitochondrial biogenesis	50	7.10e-01	8.00e-01	0.1050	-1.91e-02	7.70e-02	-0.017300	-0.066500	8.15e-01	0.34700	8.33e-01	4.17e-01
DNA Double Strand Break Response	35	7.11e-01	8.01e-01	0.1460	-1.70e-02	1.55e-02	-0.040400	0.139000	8.62e-01	0.87400	6.80e-01	1.57e-01
DAP12 signaling	21	7.13e-01	8.02e-01	0.1760	-9.36e-03	1.56e-01	0.074100	-0.034600	9.41e-01	0.21700	5.57e-01	7.84e-01
RHOV GTPase cycle	24	7.14e-01	8.02e-01	0.1770	7.77e-02	-1.56e-01	0.007630	-0.028700	5.11e-01	0.18600	9.48e-01	8.08e-01
FOXO-mediated transcription of cell cycle genes	13	7.14e-01	8.02e-01	0.2340	5.43e-02	-6.20e-02	-0.219000	0.008100	7.35e-01	0.69900	1.71e-01	9.60e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	7.17e-01	8.04e-01	0.2020	1.69e-01	-1.07e-01	0.013900	-0.014000	2.14e-01	0.43000	9.19e-01	9.18e-01
Protein ubiquitination	59	7.19e-01	8.05e-01	0.1040	7.43e-02	-8.92e-03	0.042600	0.058100	3.25e-01	0.90600	5.72e-01	4.41e-01
Neurotransmitter release cycle	19	7.20e-01	8.05e-01	0.1680	-3.52e-03	9.22e-02	-0.087800	-0.109000	9.79e-01	0.48700	5.08e-01	4.09e-01
Caspase-mediated cleavage of cytoskeletal proteins	10	7.21e-01	8.05e-01	0.2720	-7.01e-02	-9.04e-02	0.225000	-0.102000	7.01e-01	0.62100	2.18e-01	5.76e-01
N-glycan antennae elongation in the medial/trans-Golgi	17	7.21e-01	8.05e-01	0.2080	-1.85e-01	9.02e-02	-0.008620	0.028600	1.87e-01	0.52000	9.51e-01	8.38e-01
Rap1 signalling	10	7.24e-01	8.05e-01	0.2630	1.69e-01	1.04e-01	0.116000	0.128000	3.56e-01	0.57000	5.24e-01	4.83e-01
Signaling by NTRK3 (TRKC)	12	7.24e-01	8.05e-01	0.2270	-1.36e-01	1.09e-02	-0.075900	-0.165000	4.16e-01	0.94800	6.49e-01	3.23e-01
Disorders of Developmental Biology	10	7.25e-01	8.05e-01	0.2380	-6.32e-02	-1.76e-01	0.128000	0.070600	7.29e-01	0.33500	4.82e-01	6.99e-01
Disorders of Nervous System Development	10	7.25e-01	8.05e-01	0.2380	-6.32e-02	-1.76e-01	0.128000	0.070600	7.29e-01	0.33500	4.82e-01	6.99e-01
Loss of function of MECP2 in Rett syndrome	10	7.25e-01	8.05e-01	0.2380	-6.32e-02	-1.76e-01	0.128000	0.070600	7.29e-01	0.33500	4.82e-01	6.99e-01
Pervasive developmental disorders	10	7.25e-01	8.05e-01	0.2380	-6.32e-02	-1.76e-01	0.128000	0.070600	7.29e-01	0.33500	4.82e-01	6.99e-01
Metalloprotease DUBs	16	7.25e-01	8.05e-01	0.1980	1.38e-01	-1.77e-02	0.110000	0.088900	3.39e-01	0.90300	4.48e-01	5.38e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	14	7.27e-01	8.06e-01	0.2160	-2.14e-03	4.19e-02	0.145000	0.154000	9.89e-01	0.78600	3.49e-01	3.18e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	33	7.28e-01	8.06e-01	0.1450	1.26e-01	-6.24e-02	-0.036800	0.004180	2.11e-01	0.53500	7.15e-01	9.67e-01
Diseases of mitotic cell cycle	34	7.28e-01	8.06e-01	0.1440	1.22e-01	-6.22e-02	-0.044900	-0.002740	2.20e-01	0.53100	6.51e-01	9.78e-01
Attenuation phase	19	7.29e-01	8.06e-01	0.1800	-1.48e-01	-9.38e-02	-0.002640	0.041200	2.64e-01	0.47900	9.84e-01	7.56e-01
Interleukin-35 Signalling	11	7.33e-01	8.09e-01	0.2510	1.45e-01	7.26e-02	-0.174000	0.079400	4.06e-01	0.67700	3.17e-01	6.48e-01
TICAM1-dependent activation of IRF3/IRF7	12	7.33e-01	8.09e-01	0.2410	-6.31e-02	6.66e-02	0.076000	0.209000	7.05e-01	0.69000	6.49e-01	2.09e-01
Signaling by ERBB2	32	7.36e-01	8.12e-01	0.1480	-1.11e-01	7.98e-02	0.053800	0.008770	2.76e-01	0.43500	5.99e-01	9.32e-01
DNA Damage Recognition in GG-NER	35	7.45e-01	8.21e-01	0.1290	-7.20e-02	-9.52e-02	-0.039500	0.029700	4.61e-01	0.33000	6.86e-01	7.61e-01
Regulation of innate immune responses to cytosolic DNA	12	7.53e-01	8.28e-01	0.2110	-1.14e-01	-1.65e-01	0.029600	0.059500	4.94e-01	0.32400	8.59e-01	7.21e-01
RUNX2 regulates osteoblast differentiation	11	7.56e-01	8.32e-01	0.2140	-3.79e-02	-1.19e-01	0.143000	0.099600	8.28e-01	0.49600	4.12e-01	5.67e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	34	7.58e-01	8.33e-01	0.1430	-3.30e-02	3.47e-02	-0.031800	0.131000	7.40e-01	0.72600	7.49e-01	1.86e-01
Assembly and cell surface presentation of NMDA receptors	11	7.60e-01	8.33e-01	0.2600	-9.12e-02	1.69e-01	-0.122000	0.125000	6.01e-01	0.33200	4.82e-01	4.72e-01
TICAM1, RIP1-mediated IKK complex recruitment	17	7.60e-01	8.33e-01	0.1860	1.60e-01	-8.18e-02	0.017200	0.047700	2.55e-01	0.56000	9.02e-01	7.33e-01
Interleukin-12 signaling	35	7.63e-01	8.36e-01	0.1390	4.12e-02	1.16e-01	0.033800	0.055100	6.73e-01	0.23800	7.29e-01	5.73e-01
Ephrin signaling	11	7.66e-01	8.38e-01	0.2500	-1.08e-01	-1.69e-01	0.037300	-0.145000	5.36e-01	0.33200	8.31e-01	4.05e-01
Signalling to RAS	13	7.66e-01	8.38e-01	0.1990	6.50e-02	-9.16e-02	0.140000	0.085800	6.85e-01	0.56800	3.84e-01	5.93e-01
Potassium Channels	25	7.67e-01	8.38e-01	0.1570	-9.09e-02	1.04e-02	0.126000	-0.018400	4.32e-01	0.92800	2.76e-01	8.73e-01
RNA Polymerase III Transcription Termination	20	7.70e-01	8.40e-01	0.1820	5.00e-03	4.23e-02	-0.157000	0.080500	9.69e-01	0.74400	2.23e-01	5.33e-01
TNFR1-induced proapoptotic signaling	11	7.72e-01	8.41e-01	0.2430	3.98e-02	-1.74e-01	-0.148000	-0.072600	8.19e-01	0.31700	3.96e-01	6.77e-01
RORA activates gene expression	10	7.82e-01	8.51e-01	0.2360	-6.96e-02	1.36e-01	0.159000	-0.084500	7.03e-01	0.45700	3.85e-01	6.44e-01
VEGFR2 mediated cell proliferation	16	7.90e-01	8.59e-01	0.1850	-1.43e-01	-4.80e-03	0.002320	-0.117000	3.22e-01	0.97300	9.87e-01	4.20e-01
Synthesis of bile acids and bile salts	13	7.97e-01	8.67e-01	0.2140	1.80e-01	-3.61e-02	0.064900	-0.090100	2.61e-01	0.82200	6.85e-01	5.74e-01
Activation of BAD and translocation to mitochondria	14	8.01e-01	8.69e-01	0.1930	-2.57e-02	-1.80e-02	0.189000	0.024100	8.68e-01	0.90700	2.20e-01	8.76e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	8.02e-01	8.69e-01	0.1840	2.30e-02	2.95e-02	-0.176000	-0.038200	8.77e-01	0.84300	2.38e-01	7.98e-01
Signaling by FGFR3	26	8.03e-01	8.69e-01	0.1480	-5.54e-02	-1.07e-02	0.082200	-0.109000	6.25e-01	0.92500	4.68e-01	3.34e-01
RNA Pol II CTD phosphorylation and interaction with CE	23	8.03e-01	8.69e-01	0.1540	-1.28e-02	3.15e-02	0.037400	0.145000	9.15e-01	0.79400	7.56e-01	2.28e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	23	8.03e-01	8.69e-01	0.1540	-1.28e-02	3.15e-02	0.037400	0.145000	9.15e-01	0.79400	7.56e-01	2.28e-01
Signaling by FGFR1	28	8.04e-01	8.69e-01	0.1380	-6.08e-02	-1.64e-02	0.123000	-0.002740	5.78e-01	0.88100	2.61e-01	9.80e-01
Syndecan interactions	10	8.07e-01	8.71e-01	0.2300	-2.07e-01	-8.75e-02	0.006020	-0.048600	2.56e-01	0.63200	9.74e-01	7.90e-01
Signaling by FGFR4	25	8.09e-01	8.72e-01	0.1510	-9.18e-02	-4.68e-02	0.070100	-0.084900	4.27e-01	0.68600	5.45e-01	4.63e-01
Base-Excision Repair, AP Site Formation	13	8.11e-01	8.75e-01	0.2010	-5.12e-02	-1.15e-01	-0.157000	0.004220	7.49e-01	0.47300	3.27e-01	9.79e-01
TP53 Regulates Transcription of Cell Death Genes	30	8.15e-01	8.78e-01	0.1420	7.53e-02	-7.26e-02	0.076500	-0.057400	4.76e-01	0.49200	4.69e-01	5.87e-01
Transcriptional Regulation by VENTX	30	8.16e-01	8.78e-01	0.1200	4.77e-02	-3.80e-02	0.070600	0.075400	6.52e-01	0.71900	5.04e-01	4.75e-01
Signaling by FGFR2 in disease	23	8.23e-01	8.85e-01	0.1590	-2.93e-02	5.41e-02	-0.121000	0.082800	8.08e-01	0.65400	3.17e-01	4.92e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	41	8.27e-01	8.86e-01	0.1080	8.22e-02	1.06e-02	0.033100	0.060700	3.63e-01	0.90600	7.14e-01	5.02e-01
Metabolism of water-soluble vitamins and cofactors	79	8.27e-01	8.86e-01	0.0752	3.58e-02	-1.75e-02	0.056000	0.030500	5.83e-01	0.78900	3.91e-01	6.41e-01
Signaling by FGFR in disease	39	8.27e-01	8.86e-01	0.1100	5.73e-02	4.70e-02	0.062300	-0.052100	5.36e-01	0.61200	5.01e-01	5.74e-01
RHOU GTPase cycle	26	8.28e-01	8.86e-01	0.1280	-3.48e-02	-9.69e-02	0.072700	0.023200	7.59e-01	0.39300	5.21e-01	8.38e-01
Bile acid and bile salt metabolism	14	8.31e-01	8.86e-01	0.2020	1.17e-01	-8.19e-02	0.097900	-0.105000	4.50e-01	0.59600	5.26e-01	4.95e-01
APC truncation mutants have impaired AXIN binding	12	8.33e-01	8.86e-01	0.2010	1.53e-01	7.08e-02	0.104000	0.031500	3.58e-01	0.67100	5.34e-01	8.50e-01
AXIN missense mutants destabilize the destruction complex	12	8.33e-01	8.86e-01	0.2010	1.53e-01	7.08e-02	0.104000	0.031500	3.58e-01	0.67100	5.34e-01	8.50e-01
Signaling by AMER1 mutants	12	8.33e-01	8.86e-01	0.2010	1.53e-01	7.08e-02	0.104000	0.031500	3.58e-01	0.67100	5.34e-01	8.50e-01
Signaling by APC mutants	12	8.33e-01	8.86e-01	0.2010	1.53e-01	7.08e-02	0.104000	0.031500	3.58e-01	0.67100	5.34e-01	8.50e-01
Signaling by AXIN mutants	12	8.33e-01	8.86e-01	0.2010	1.53e-01	7.08e-02	0.104000	0.031500	3.58e-01	0.67100	5.34e-01	8.50e-01
Truncations of AMER1 destabilize the destruction complex	12	8.33e-01	8.86e-01	0.2010	1.53e-01	7.08e-02	0.104000	0.031500	3.58e-01	0.67100	5.34e-01	8.50e-01
RND1 GTPase cycle	29	8.34e-01	8.87e-01	0.1290	1.17e-01	2.41e-02	-0.035700	0.033200	2.75e-01	0.82300	7.39e-01	7.57e-01
Signaling by PDGF	25	8.37e-01	8.88e-01	0.1380	-1.51e-02	3.74e-02	0.125000	0.044400	8.96e-01	0.74600	2.81e-01	7.01e-01
Signaling by FLT3 ITD and TKD mutants	13	8.39e-01	8.88e-01	0.1930	-2.92e-02	2.92e-02	0.186000	-0.035300	8.55e-01	0.85500	2.47e-01	8.26e-01
Signaling by FGFR	51	8.39e-01	8.88e-01	0.1010	-4.75e-02	4.72e-02	0.056500	0.050000	5.58e-01	0.56000	4.86e-01	5.38e-01
KSRP (KHSRP) binds and destabilizes mRNA	15	8.39e-01	8.88e-01	0.1830	-8.29e-03	-9.44e-02	-0.119000	-0.102000	9.56e-01	0.52700	4.24e-01	4.94e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	11	8.39e-01	8.88e-01	0.2080	-1.47e-01	-1.33e-01	0.039700	-0.050300	3.99e-01	0.44700	8.20e-01	7.73e-01
TGF-beta receptor signaling activates SMADs	32	8.40e-01	8.89e-01	0.1190	-1.12e-01	-3.22e-02	0.009350	0.021600	2.73e-01	0.75300	9.27e-01	8.33e-01
Unfolded Protein Response (UPR)	70	8.43e-01	8.91e-01	0.0815	3.86e-02	3.18e-02	0.061600	-0.018900	5.77e-01	0.64600	3.74e-01	7.85e-01
Vitamin B5 (pantothenate) metabolism	11	8.51e-01	8.98e-01	0.1940	-4.29e-02	-2.97e-02	0.177000	0.060200	8.05e-01	0.86500	3.11e-01	7.30e-01
Metabolism of folate and pterines	11	8.53e-01	8.98e-01	0.1960	5.05e-02	-1.14e-02	0.182000	0.051900	7.72e-01	0.94800	2.97e-01	7.66e-01
Glucose metabolism	72	8.53e-01	8.98e-01	0.0808	-2.64e-02	3.24e-02	0.058600	0.036800	6.99e-01	0.63600	3.91e-01	5.90e-01
Signaling by KIT in disease	17	8.54e-01	8.98e-01	0.1520	5.98e-02	-7.89e-02	-0.060600	0.098500	6.70e-01	0.57300	6.65e-01	4.82e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	17	8.54e-01	8.98e-01	0.1520	5.98e-02	-7.89e-02	-0.060600	0.098500	6.70e-01	0.57300	6.65e-01	4.82e-01
Elastic fibre formation	17	8.55e-01	8.98e-01	0.1620	-9.89e-02	2.49e-03	0.065400	-0.110000	4.81e-01	0.98600	6.41e-01	4.34e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	8.56e-01	8.98e-01	0.1380	8.16e-02	-1.00e-01	-0.003250	-0.047500	4.64e-01	0.36800	9.77e-01	6.70e-01
Visual phototransduction	30	8.57e-01	8.98e-01	0.1300	-4.89e-02	8.67e-02	-0.068800	0.046600	6.44e-01	0.41100	5.15e-01	6.59e-01
Cleavage of the damaged pyrimidine	12	8.58e-01	8.98e-01	0.1960	5.68e-03	-1.41e-01	-0.131000	-0.036100	9.73e-01	0.39900	4.33e-01	8.29e-01
Depyrimidination	12	8.58e-01	8.98e-01	0.1960	5.68e-03	-1.41e-01	-0.131000	-0.036100	9.73e-01	0.39900	4.33e-01	8.29e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	12	8.58e-01	8.98e-01	0.1960	5.68e-03	-1.41e-01	-0.131000	-0.036100	9.73e-01	0.39900	4.33e-01	8.29e-01
Signaling by FLT3 fusion proteins	17	8.60e-01	8.98e-01	0.1650	1.91e-02	9.25e-03	0.137000	-0.088500	8.92e-01	0.94700	3.28e-01	5.28e-01
Metal ion SLC transporters	15	8.60e-01	8.98e-01	0.1770	1.14e-01	-6.34e-02	0.111000	-0.046700	4.46e-01	0.67100	4.57e-01	7.54e-01
TRAF6 mediated NF-kB activation	18	8.61e-01	8.98e-01	0.1550	7.88e-03	7.80e-02	0.130000	-0.028900	9.54e-01	0.56700	3.39e-01	8.32e-01
Mitochondrial calcium ion transport	18	8.62e-01	8.98e-01	0.1480	-8.85e-02	-6.91e-02	-0.059100	0.075900	5.16e-01	0.61200	6.64e-01	5.77e-01
IKK complex recruitment mediated by RIP1	17	8.63e-01	8.99e-01	0.1490	1.09e-01	-6.44e-02	0.030700	0.071800	4.35e-01	0.64600	8.27e-01	6.09e-01
Metabolism of nitric oxide: NOS3 activation and regulation	11	8.66e-01	9.01e-01	0.2190	-2.61e-02	1.45e-01	-0.074400	0.143000	8.81e-01	0.40600	6.69e-01	4.10e-01
Diseases of programmed cell death	34	8.68e-01	9.02e-01	0.1210	1.79e-02	8.04e-02	0.018300	0.086000	8.57e-01	0.41700	8.53e-01	3.86e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	15	8.69e-01	9.03e-01	0.1680	7.94e-03	-3.89e-03	-0.166000	0.025100	9.58e-01	0.97900	2.65e-01	8.66e-01
CD209 (DC-SIGN) signaling	15	8.73e-01	9.06e-01	0.1680	-8.49e-02	6.20e-02	0.128000	0.025000	5.69e-01	0.67800	3.90e-01	8.67e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	22	8.74e-01	9.06e-01	0.1380	-8.81e-02	3.76e-02	0.083600	0.053700	4.75e-01	0.76000	4.98e-01	6.63e-01
Depolymerisation of the Nuclear Lamina	13	8.78e-01	9.09e-01	0.1820	2.28e-02	9.03e-02	0.078000	0.136000	8.87e-01	0.57300	6.26e-01	3.96e-01
FLT3 signaling in disease	25	8.83e-01	9.14e-01	0.1260	-1.07e-01	1.95e-02	0.062400	0.012200	3.57e-01	0.86600	5.89e-01	9.16e-01
Mitochondrial iron-sulfur cluster biogenesis	10	8.85e-01	9.15e-01	0.2030	1.36e-01	-1.25e-01	-0.079100	-0.026100	4.56e-01	0.49400	6.65e-01	8.86e-01
Synthesis of PIPs at the Golgi membrane	12	8.88e-01	9.17e-01	0.1800	-4.38e-02	2.88e-02	0.158000	-0.069600	7.93e-01	0.86300	3.44e-01	6.77e-01
Signaling by FGFR2	47	8.96e-01	9.25e-01	0.0897	-8.24e-02	1.71e-02	0.017100	0.026000	3.29e-01	0.84000	8.39e-01	7.58e-01
Activation of BH3-only proteins	27	8.97e-01	9.25e-01	0.1150	-9.04e-02	-6.38e-02	-0.016400	-0.028100	4.16e-01	0.56700	8.83e-01	8.01e-01
Downstream signaling of activated FGFR1	12	9.00e-01	9.25e-01	0.1620	3.79e-02	1.40e-01	-0.069500	-0.014600	8.20e-01	0.40100	6.77e-01	9.30e-01
Downstream signaling of activated FGFR2	12	9.00e-01	9.25e-01	0.1620	3.79e-02	1.40e-01	-0.069500	-0.014600	8.20e-01	0.40100	6.77e-01	9.30e-01
Downstream signaling of activated FGFR3	12	9.00e-01	9.25e-01	0.1620	3.79e-02	1.40e-01	-0.069500	-0.014600	8.20e-01	0.40100	6.77e-01	9.30e-01
Downstream signaling of activated FGFR4	12	9.00e-01	9.25e-01	0.1620	3.79e-02	1.40e-01	-0.069500	-0.014600	8.20e-01	0.40100	6.77e-01	9.30e-01
Glycolysis	57	9.05e-01	9.29e-01	0.0862	-2.96e-03	5.30e-02	-0.010100	0.067200	9.69e-01	0.49000	8.95e-01	3.81e-01
Metabolic disorders of biological oxidation enzymes	14	9.09e-01	9.32e-01	0.1630	1.30e-01	-5.19e-02	0.037100	-0.075200	3.99e-01	0.73700	8.10e-01	6.26e-01
Pyruvate metabolism	20	9.10e-01	9.32e-01	0.1310	1.01e-01	4.25e-02	-0.036200	0.061700	4.34e-01	0.74200	7.79e-01	6.33e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	19	9.13e-01	9.35e-01	0.1340	3.92e-02	6.68e-02	0.071500	0.082800	7.67e-01	0.61400	5.90e-01	5.32e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	18	9.16e-01	9.36e-01	0.1300	-3.09e-02	1.85e-02	0.073200	0.101000	8.21e-01	0.89200	5.91e-01	4.57e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	12	9.16e-01	9.36e-01	0.1650	1.07e-01	4.51e-03	-0.097700	0.077500	5.20e-01	0.97800	5.58e-01	6.42e-01
NOTCH3 Intracellular Domain Regulates Transcription	14	9.23e-01	9.42e-01	0.1470	-5.85e-02	3.43e-02	0.130000	0.014400	7.05e-01	0.82400	3.99e-01	9.26e-01
Signaling by NTRK2 (TRKB)	16	9.24e-01	9.42e-01	0.1450	4.96e-02	1.14e-01	0.025300	0.068700	7.32e-01	0.42900	8.61e-01	6.34e-01
Integrin cell surface interactions	25	9.24e-01	9.42e-01	0.1070	-7.41e-02	-6.46e-03	0.070900	0.029400	5.22e-01	0.95500	5.40e-01	7.99e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	9.32e-01	9.48e-01	0.1260	7.84e-02	-4.75e-03	-0.093600	0.031700	5.65e-01	0.97200	4.92e-01	8.16e-01
Processing of SMDT1	12	9.32e-01	9.48e-01	0.1350	-5.32e-03	-1.10e-01	0.013300	0.076500	9.75e-01	0.51000	9.37e-01	6.47e-01
Tie2 Signaling	10	9.32e-01	9.48e-01	0.1660	5.37e-03	2.56e-02	0.159000	0.040200	9.77e-01	0.88900	3.85e-01	8.26e-01
STING mediated induction of host immune responses	10	9.43e-01	9.58e-01	0.1610	-3.75e-02	5.77e-02	0.146000	-0.003900	8.37e-01	0.75200	4.26e-01	9.83e-01
Ovarian tumor domain proteases	28	9.47e-01	9.61e-01	0.0946	-1.17e-03	1.52e-02	0.092500	-0.012900	9.91e-01	0.89000	3.98e-01	9.06e-01
Long-term potentiation	10	9.50e-01	9.63e-01	0.1530	-1.11e-01	-5.59e-02	-0.084700	0.024100	5.42e-01	0.76000	6.43e-01	8.95e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	14	9.51e-01	9.63e-01	0.1280	-4.81e-02	8.96e-02	-0.077300	0.003470	7.56e-01	0.56200	6.17e-01	9.82e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	14	9.51e-01	9.63e-01	0.1280	-4.81e-02	8.96e-02	-0.077300	0.003470	7.56e-01	0.56200	6.17e-01	9.82e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	9.56e-01	9.66e-01	0.1190	1.05e-01	-3.82e-02	-0.040600	0.003780	4.69e-01	0.79200	7.79e-01	9.79e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	9.56e-01	9.66e-01	0.1190	1.05e-01	-3.82e-02	-0.040600	0.003780	4.69e-01	0.79200	7.79e-01	9.79e-01
Other interleukin signaling	15	9.58e-01	9.67e-01	0.1250	-9.80e-02	5.91e-02	0.035300	0.035800	5.11e-01	0.69200	8.13e-01	8.11e-01
Endosomal/Vacuolar pathway	11	9.64e-01	9.72e-01	0.1290	-1.03e-01	2.09e-02	-0.003900	-0.074400	5.54e-01	0.90500	9.82e-01	6.70e-01
Protein methylation	12	9.69e-01	9.77e-01	0.1280	-6.26e-02	1.03e-01	-0.032200	0.030000	7.07e-01	0.53700	8.47e-01	8.57e-01
Formation of tubulin folding intermediates by CCT/TriC	14	9.73e-01	9.79e-01	0.1110	6.63e-02	3.38e-02	0.006710	0.082300	6.68e-01	0.82700	9.65e-01	5.94e-01
Association of TriC/CCT with target proteins during biosynthesis	29	9.74e-01	9.79e-01	0.0766	3.70e-02	3.14e-02	-0.054800	0.022500	7.31e-01	0.77000	6.10e-01	8.34e-01
Miscellaneous transport and binding events	14	9.74e-01	9.79e-01	0.1070	6.17e-05	6.78e-03	-0.106000	-0.008220	1.00e+00	0.96500	4.92e-01	9.58e-01
FOXO-mediated transcription	46	9.76e-01	9.80e-01	0.0522	-6.84e-03	-2.46e-02	0.030400	0.033900	9.36e-01	0.77300	7.22e-01	6.91e-01
Prefoldin mediated transfer of substrate to CCT/TriC	17	9.78e-01	9.82e-01	0.0994	1.24e-02	8.07e-02	0.034300	0.045100	9.29e-01	0.56500	8.07e-01	7.48e-01
Downstream signal transduction	21	9.82e-01	9.85e-01	0.0818	7.23e-03	3.52e-02	0.043900	0.058900	9.54e-01	0.78000	7.28e-01	6.40e-01
Aggrephagy	18	9.83e-01	9.85e-01	0.0850	-8.26e-02	-4.37e-03	-0.016900	0.009880	5.44e-01	0.97400	9.01e-01	9.42e-01
Metabolism of nucleotides	68	9.89e-01	9.89e-01	0.0418	-3.16e-02	1.05e-02	-0.016900	0.018800	6.52e-01	0.88200	8.10e-01	7.89e-01
Methylation	10	9.96e-01	9.96e-01	0.0799	1.25e-02	8.18e-03	-0.065500	0.043300	9.46e-01	0.96400	7.20e-01	8.13e-01

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Detailed Gene set reports

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	70
pMANOVA	7.69e-38
p.adjustMANOVA	8.93e-35
s.dist	0.935
s.t0_crp_RNA	-0.625
s.t0_crp_meth	-0.09
s.pod_crp_RNA	-0.658
s.pod_crp_meth	0.205
p.t0_crp_RNA	1.5e-19
p.t0_crp_meth	0.194
p.pod_crp_RNA	1.73e-21
p.pod_crp_meth	0.00304

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
EEF1G	-4201	-4651
EEF1B2	-4265	-4461
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
EEF1A1	-4432	-3462
RPS27A	-4078	-3731
RPS16	-3448	-4379
EEF2	-3170	-4680
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
EEF1A1	-3462	2007	-4432	2941
EEF1B2	-4461	5596	-4265	3976
EEF1D	-4492	7623	-2131	5789
EEF1G	-4651	718	-4201	111
EEF2	-4680	1309	-3170	4195
FAU	-4223	5971	-437	6875
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
UBA52	-3208	4386	-596	-69

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Neutrophil degranulation

Neutrophil degranulation

metric	value
setSize	305
pMANOVA	1.65e-35
p.adjustMANOVA	9.58e-33
s.dist	0.439
s.t0_crp_RNA	-0.0244
s.t0_crp_meth	-0.027
s.pod_crp_RNA	0.432
s.pod_crp_meth	-0.0637
p.t0_crp_RNA	0.469
p.t0_crp_meth	0.421
p.pod_crp_RNA	3.42e-38
p.pod_crp_meth	0.058

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	pod_crp_meth
P2RX1	4586	-1947
UNC13D	4403	-1904
TYROBP	4152	-1995
CTSZ	4162	-1978
CD300A	4103	-1998
PYCARD	4319	-1818
TRPM2	4355	-1792
NAPRT	4098	-1869
C3AR1	4547	-1594
ATP6V0A1	4481	-1569
MNDA	3506	-1994
IGF2R	3850	-1657
SERPINB1	4236	-1477
CYSTM1	3572	-1740
AGPAT2	4455	-1386
ARSB	3997	-1526
LAMTOR1	3758	-1587
QPCT	3998	-1472
VAT1	4292	-1357
SLC15A4	3676	-1575

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
A1BG	-4720	7280	525	567
ACAA1	-1087	6265	4528	5788
ACLY	-1395	2347	3652	2976
ACTR10	2603	5113	1646	4867
ACTR1B	-3875	3798	-2148	2629
ACTR2	3144	4932	2747	3844
ADAM10	2914	3590	3423	2760
ADAM8	-2204	7454	2256	5096
ADGRE5	-2627	2052	3671	-1468
AGA	-2883	-401	-2619	2162
AGL	2065	2754	-959	1016
AGPAT2	-3761	-328	4455	-1386
ALAD	-4161	371	4014	1057
ALDOA	-1859	643	4238	5366
ALDOC	-367	7284	-2691	65
ALOX5	330	6127	4345	5385
AMPD3	-1687	4553	3545	3216
ANO6	-849	7646	-21	1102
AP1M1	-4217	2143	3873	1777
APAF1	1473	7512	2266	-809
APEH	-3872	429	1730	832
APRT	-4283	7658	-2811	2643
ARHGAP9	-2519	389	4113	6255
ARL8A	-3571	135	3462	-1057
ARMC8	3399	4263	67	2641
ARPC5	2109	2335	3836	2611
ARSA	1972	-580	3635	523
ARSB	1416	6851	3997	-1526
ASAH1	2991	3487	4461	2174
ATAD3B	-3224	5569	-2736	4810
ATG7	2082	1256	2282	3847
ATP11A	-1708	5464	4170	132
ATP11B	1100	-213	1786	-241
ATP6V0A1	-73	5522	4481	-1569
ATP6V0C	-819	2497	4204	2933
ATP6V1D	3158	446	3682	1096
ATP8A1	-1321	-197	-4498	-913
ATP8B4	80	-467	612	-1099
B2M	3496	3645	-3314	-9
B4GALT1	-2606	7929	1953	7041
BIN2	-3373	3302	4006	5389
BRI3	-1874	3754	4413	-1176
BST2	1250	-703	383	-1933
C3AR1	4000	1722	4547	-1594
C6orf120	-845	7883	319	3829
CAB39	2427	-206	2233	7106
CAND1	2021	1725	-3244	2163
CAP1	497	5559	3138	2034
CAPN1	-3906	5471	3918	1819
CAT	282	-220	3549	-1204
CCT2	1454	3443	-4591	194
CCT8	2610	2003	-111	2904
CD300A	2225	-861	4103	-1998
CD44	498	4392	3154	4897
CD47	2166	2442	-3816	6601
CD53	2247	-462	3926	6482
CD55	1738	3285	4145	1455
CD58	4062	5810	3835	-611
CD59	-1703	4468	-1328	-1682
CD63	-2910	7177	4520	5433
CDK13	-2241	5468	9	5777
CEACAM1	-237	822	1684	5458
CEP290	4268	7316	-2743	7000
CKAP4	-813	8287	3854	-987
CMTM6	3583	4072	2869	1926
CNN2	-1565	2034	1954	-418
COMMD3	3610	606	665	-1960
COMMD9	1680	85	3383	2239
COPB1	4354	2889	2313	2637
COTL1	671	2421	4276	6759
CPNE1	-1872	4807	-478	5131
CPNE3	1598	2499	-94	-1441
CPPED1	340	5747	4044	-641
CREG1	-2492	1563	2917	-1059
CSNK2B	63	7476	2450	4742
CSTB	469	6900	4229	2893
CTSA	-2481	2086	4047	2720
CTSB	83	7057	4475	-965
CTSC	2238	2310	3599	1311
CTSD	-3067	8404	4479	6620
CTSS	2274	-506	2686	-1544
CTSZ	-1191	-74	4162	-1978
CYB5R3	-4015	4980	3732	3239
CYBA	-2911	5359	4087	2019
CYFIP1	644	8297	4331	256
CYSTM1	594	7301	3572	-1740
DBNL	-4518	2964	3614	-406
DEGS1	-1317	4783	-164	3203
DERA	3518	7409	3669	3602
DGAT1	-3399	6428	2057	-576
DIAPH1	-659	5118	910	2371
DNAJC13	3873	207	3651	408
DNAJC3	2858	8289	3092	6470
DNAJC5	-2985	3110	3776	-1396
DPP7	-4644	7245	-1735	6584
DSN1	2407	2698	-1398	-996
DYNC1H1	-2872	1165	-441	4433
DYNC1LI1	3353	6061	2935	3242
DYNLL1	-405	5371	1250	5150
DYNLT1	2953	4660	2802	5599
EEF1A1	-3462	2007	-4432	2941
EEF2	-4680	1309	-3170	4195
ENPP4	1515	1338	-2234	3170
ERP44	3533	127	1159	920
FABP5	1248	3657	2416	2233
FAF2	230	7630	1614	2842
FGR	-1601	6431	4539	-1074
FTH1	-378	3718	2380	3117
FTL	609	3955	3972	-1424
FUCA1	-689	2325	2425	1656
FUCA2	1128	614	2428	-1234
GAA	-1924	1082	3079	2768
GALNS	-2319	6550	3709	3670
GCA	3226	2697	4151	5559
GDI2	3001	7874	2004	3343
GGH	2821	6701	1044	3861
GHDC	-3703	2847	1243	-571
GLB1	890	7186	4196	1828
GLIPR1	3846	390	2195	5591
GM2A	2719	6404	4388	6361
GMFG	254	6320	3611	6367
GNS	1404	5454	4533	4428
GOLGA7	1327	3410	-2030	3104
GPI	-2280	6574	1799	5672
GRN	-475	3078	4312	4937
GSDMD	-2417	4172	1671	-91
GSTP1	-976	6809	683	-1350
GUSB	-2488	4868	4470	2338
GYG1	-319	6447	3938	-231
HEBP2	-1887	5561	2156	552
HEXB	1519	7559	2594	2906
HGSNAT	-63	352	-1489	3342
HLA-A	-4080	2266	-2368	-1093
HLA-B	-821	510	896	-730
HLA-C	51	6767	1218	4448
HLA-H	-4350	7821	-546	4988
HMGB1	1943	2521	-3489	3222
HMOX2	-3769	699	-4339	6411
HSP90AA1	3100	4857	-2176	6208
HSP90AB1	1227	824	-4305	-1224
HSPA1A	-3490	1106	2517	-920
HSPA1B	1576	750	1718	655
HVCN1	-951	1427	1485	-385
IDH1	3628	3280	4526	3454
IGF2R	-4041	-23	3850	-1657
ILF2	2531	-350	-1689	2770
IMPDH1	-1286	6	4428	2600
IMPDH2	-3789	5334	-4679	250
IQGAP1	-6	372	3381	587
IQGAP2	2140	2768	3344	3888
IST1	2520	1926	2863	1014
ITGAL	-1994	4404	1129	7036
ITGAV	2010	3274	3023	-370
ITGB2	-4211	745	4253	6424
KCMF1	1322	-488	1586	3310
KCNAB2	-4643	5909	2760	-600
KPNB1	2659	5901	-47	1140
LAIR1	-901	6730	4482	3425
LAMP1	-4014	7954	3219	2553
LAMTOR1	-4534	-643	3758	-1587
LAMTOR2	-3989	-286	3497	-1340
LAMTOR3	3368	6744	792	957
LPCAT1	-2710	-419	1992	1418
LTA4H	2233	5699	4301	798
MAN2B1	-2647	7254	2518	6387
MANBA	3782	4762	2996	6844
MAPK1	-745	2758	4197	6097
MAPK14	1563	2227	4024	2465
MIF	-3715	2437	-3047	3355
MLEC	-1358	5314	-1498	2183
MMP25	-966	6396	4100	6852
MNDA	3361	1442	3506	-1994
MPO	-3878	344	-3645	-1967
MVP	-3502	7998	3433	6953
NAPRT	214	-73	4098	-1869
NBEAL2	-2403	5606	4127	1726
NCKAP1L	650	1928	4458	-320
NCSTN	1556	-453	4578	1224
NDUFC2	-2586	5313	2549	2881
NEU1	660	3057	4459	1899
NHLRC3	3852	5873	2633	4505
NIT2	2452	1153	-3459	-141
NME2	1390	1732	-173	-880
NPC2	2405	6347	2830	2198
ORMDL3	-3219	2570	-3756	3085
OSCAR	1666	2313	4583	7120
OSTF1	1009	7525	2469	6468
P2RX1	2272	2764	4586	-1947
PA2G4	1938	2826	-2412	5242
PAFAH1B2	2330	4486	909	2435
PDAP1	-4405	8096	3697	2952
PDXK	-1102	4954	2867	1492
PFKL	-4475	23	464	-1730
PGAM1	-1229	1586	4418	1307
PGM1	-3622	4559	1829	776
PGM2	1298	3342	3609	5133
PKM	-1111	1474	4062	3231
PLAC8	-1486	3803	4406	1235
PLAU	-1912	5281	914	-1527
PLAUR	226	4310	4189	-861
PLD1	2370	2188	4049	-902
PLEKHO2	703	6284	4254	6697
PNP	823	2158	3217	3516
PPIA	-239	5602	-1924	4554
PPIE	1995	6743	-2167	6025
PRCP	2944	6346	2835	611
PRDX6	-1247	4144	-345	5477
PRKCD	301	8167	4500	6358
PRTN3	-4653	8354	-2832	5619
PSAP	506	1283	3823	628
PSEN1	2104	1717	4209	4954
PSMA2	1509	4929	-836	5163
PSMA5	3047	4175	-2828	3319
PSMB1	-371	2981	-803	5409
PSMB7	-2378	1587	2955	4198
PSMC3	-2624	4680	847	736
PSMD1	2911	5546	2375	56
PSMD11	4009	2032	2637	3521
PSMD12	4511	5250	2167	3681
PSMD13	-998	7807	1482	561
PSMD14	3360	3896	85	6314
PSMD2	-3334	6719	2097	3610
PSMD3	-4637	3063	1629	5579
PSMD6	1854	3171	3275	2336
PSMD7	3595	864	596	2079
PTGES2	-4318	-433	-1375	-901
PTPN6	-1174	2534	4395	6540
PTPRC	3660	1759	2823	-936
PTPRJ	-2062	6860	3552	7167
PTPRN2	-1502	1639	-965	6583
PYCARD	-1515	3142	4319	-1818
PYGB	-3390	-229	-1259	141
QPCT	1033	1841	3998	-1472
QSOX1	-2300	6788	4519	5725
RAB10	2203	1022	4224	3067
RAB14	3720	1861	1150	-378
RAB18	4478	1161	1696	2764
RAB24	1932	257	4083	-168
RAB27A	3269	7260	2952	222
RAB37	-1677	7528	-2789	409
RAB3A	-4569	3507	482	4347
RAB3D	604	5944	3885	1148
RAB4B	-2727	7770	3909	4687
RAB5B	-516	1208	1896	1957
RAB5C	-2850	2984	3898	797
RAB6A	3034	6426	2839	3323
RAB7A	837	-522	3489	-124
RAC1	3574	7484	4225	5539
RAP1A	4512	2607	2624	6567
RAP1B	2749	6134	2033	5966
RAP2B	-283	6562	394	5291
RHOA	2796	1879	3280	4033
RHOF	-3403	3511	-4235	6476
RHOG	-703	3967	4093	3664
RNASET2	-1180	732	3304	7087
ROCK1	4037	2208	2623	2732
S100A11	1465	3952	4310	6087
S100P	-3641	627	3560	3303
SCAMP1	2598	7802	-3481	2645
SDCBP	3311	7419	3605	3834
SERPINB1	990	-241	4236	-1477
SERPINB6	-3927	7977	3455	2823
SLC11A1	-326	1277	4588	4001
SLC15A4	-384	-645	3676	-1575
SLC27A2	3534	3271	-3276	-1409
SLC2A3	-2653	4133	3706	-1209
SLC44A2	-3555	1449	11	4322
SLCO4C1	838	1673	1214	-99
SNAP23	2642	7973	1694	-471
SNAP29	-4308	6060	3209	3148
SPTAN1	-4171	369	-4508	-407
SRP14	2388	5802	1918	5762
STBD1	785	6119	-200	-658
STK10	-3634	3470	2725	-688
STK11IP	-4178	4530	3990	2122
STOM	312	-756	1358	-1584
SURF4	-2330	5219	1962	3679
SVIP	2044	4128	-3340	1104
TBC1D10C	-4516	3143	-3275	6910
TCIRG1	-2526	4545	4576	1353
TLR2	3806	6774	4156	4128
TMBIM1	-3251	2134	3467	-47
TMC6	-3434	1580	-1994	6748
TMEM179B	-176	1544	388	5595
TMEM30A	3654	7686	1750	6658
TMEM63A	-691	1367	-3328	2620
TNFRSF1B	-1307	1250	4281	6868
TOLLIP	-3659	1231	2911	664
TOM1	-3899	5174	4227	4279
TRAPPC1	-1916	3999	3336	5232
TRPM2	-2751	7757	4355	-1792
TSPAN14	-2003	917	4079	4962
TUBB	-357	3701	-2272	6246
TUBB4B	-2428	6398	2462	7160
TXNDC5	2037	7500	-1760	-1871
TYROBP	-1849	830	4152	-1995
UNC13D	-3097	481	4403	-1904
VAMP8	-2659	3376	1656	868
VAPA	2045	3824	3031	4245
VAT1	-3926	1426	4292	-1357
VCL	-1153	1830	476	3614
VCP	-2285	7849	1665	1908
XRCC5	1691	3512	-1013	1327
XRCC6	661	2803	-3543	3282
YPEL5	1717	-147	2447	3986

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	67
pMANOVA	2.56e-35
p.adjustMANOVA	9.9e-33
s.dist	0.923
s.t0_crp_RNA	-0.61
s.t0_crp_meth	-0.102
s.pod_crp_RNA	-0.653
s.pod_crp_meth	0.208
p.t0_crp_RNA	5.99e-18
p.t0_crp_meth	0.148
p.pod_crp_RNA	2.26e-20
p.pod_crp_meth	0.00329

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
EEF1A1	-4432	-3462
RPS27A	-4078	-3731
RPS16	-3448	-4379
EEF2	-3170	-4680
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
EEF1A1	-3462	2007	-4432	2941
EEF2	-4680	1309	-3170	4195
FAU	-4223	5971	-437	6875
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
UBA52	-3208	4386	-596	-69

---

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

metric	value
setSize	76
pMANOVA	4.35e-34
p.adjustMANOVA	1.12e-31
s.dist	0.853
s.t0_crp_RNA	-0.55
s.t0_crp_meth	-0.0824
s.pod_crp_RNA	-0.621
s.pod_crp_meth	0.182
p.t0_crp_RNA	1.11e-16
p.t0_crp_meth	0.215
p.pod_crp_RNA	8.44e-21
p.pod_crp_meth	0.00621

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
EIF3B	-4157	-3948
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
EIF3L	-3540	-4194
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
EIF3A	728	186	-641	5853
EIF3B	-3948	-637	-4157	-704
EIF3E	3043	3996	-4004	503
EIF3F	-4699	1781	-1541	1471
EIF3G	-4429	1815	-692	3038
EIF3H	-554	4996	-2590	3706
EIF3I	-3483	2651	-1095	696
EIF3J	3642	3047	-2652	737
EIF3K	-2643	8378	-128	6634
EIF3L	-4194	6675	-3540	2568
EIF3M	3156	7216	-2454	5834
FAU	-4223	5971	-437	6875
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
UBA52	-3208	4386	-596	-69

---

---

rRNA processing

rRNA processing

metric	value
setSize	159
pMANOVA	4.81e-34
p.adjustMANOVA	1.12e-31
s.dist	0.593
s.t0_crp_RNA	-0.24
s.t0_crp_meth	-0.0621
s.pod_crp_RNA	-0.524
s.pod_crp_meth	0.123
p.t0_crp_RNA	1.88e-07
p.t0_crp_meth	0.178
p.pod_crp_RNA	4.58e-30
p.pod_crp_meth	0.00784

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
FBL	-4594	-4678
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RRP9	-3731	-4587
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
EXOSC2	-3761	-3836
RPS10	-3457	-4168
EXOSC5	-3823	-3756
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
BMS1	-1273	279	-4313	-1753
BYSL	-2328	5900	-2573	6806
C1D	4279	3651	206	2322
CSNK1D	-4441	6564	2787	3046
CSNK1E	-3951	7015	-3414	3000
DCAF13	-562	1410	-1783	862
DDX21	2972	7462	-1540	3312
DDX47	4326	892	-3647	-50
DDX49	-4479	3907	1633	5580
DDX52	4531	3595	579	-204
DHX37	-3145	6236	-2526	4194
DIS3	4375	4884	-1622	-754
EBNA1BP2	-556	1401	-3067	6233
ELAC2	-936	5459	-1517	275
ERI1	3766	-203	768	-139
EXOSC1	2149	7237	992	316
EXOSC10	1827	1777	-2188	802
EXOSC2	-3836	-378	-3761	5343
EXOSC3	851	4957	110	3245
EXOSC4	-2860	5195	3343	64
EXOSC5	-3756	469	-3823	790
EXOSC6	-1352	3467	-3661	1534
EXOSC7	-4443	4094	-2938	-158
EXOSC8	3032	5356	-3616	1364
FAU	-4223	5971	-437	6875
FBL	-4678	-91	-4594	-43
FCF1	2808	5725	-1239	6761
FTSJ3	-2540	4963	1385	4235
GAR1	-224	3758	-2986	879
GNL3	2241	1853	-4428	1201
HEATR1	566	6362	-3326	5200
IMP3	-1621	6086	-3137	5540
IMP4	-2501	4256	-3803	3786
ISG20L2	530	2755	-15	6436
KRR1	2893	-801	-2865	-1950
LTV1	2852	2898	-1941	2915
MPHOSPH10	4488	5449	-2942	5400
MPHOSPH6	1961	6222	-949	5533
MRM1	-2461	2109	-3228	-159
MTERF4	-2411	5813	-4491	3503
NCL	-1980	6791	-4315	5053
NHP2	-3191	6971	-2519	4826
NIP7	1970	5730	-3733	4218
NOB1	-2719	-262	-4364	2003
NOC4L	-1413	5509	2788	-799
NOL11	3694	-390	-4414	2571
NOL12	-297	5999	2186	-1549
NOL6	-4372	6081	-3107	4556
NOL9	1673	-787	-3236	-1444
NOP10	-1724	2394	4174	2081
NOP14	-2035	-731	-4619	2209
NOP2	-3532	5036	-2782	6401
NOP56	-390	117	-3865	996
NOP58	3566	2112	-4420	1333
NSUN4	1766	777	1615	3316
PDCD11	-2808	1973	-3660	3455
PELP1	-637	6658	-3306	2742
PES1	-4103	222	-2386	3288
PNO1	2611	1456	-3399	6494
PWP2	-3288	3400	-3239	5075
RBM28	-2460	5591	-2557	3412
RCL1	-2020	7155	-3537	6341
RIOK1	2656	7804	-1376	6496
RIOK2	3564	1632	-3897	1638
RIOK3	3495	2135	1073	3472
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPP14	3290	6084	-993	2236
RPP21	-3292	6702	-86	2599
RPP25	-2510	7139	-3453	5743
RPP30	3476	4936	-3223	668
RPP38	3369	1308	-2914	4779
RPP40	1457	2935	-4562	570
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
RRP1	-894	4246	340	5199
RRP7A	-281	3244	-1932	1582
RRP9	-4587	-253	-3731	653
SENP3	-1093	8054	1649	5393
SNU13	-1800	-638	-3664	7052
TBL3	-3751	5261	19	5417
TEX10	3497	-297	-4086	1204
TFB1M	2498	2147	-1945	1831
THUMPD1	3126	1431	-4395	-871
TRMT112	-4008	7769	-160	1929
TSR1	-341	6406	-4621	6837
TSR3	-4199	1625	-151	6368
UBA52	-3208	4386	-596	-69
UTP15	4103	2192	-3831	5062
UTP18	1555	4515	1472	3357
UTP20	2389	4984	-3079	5084
UTP3	-823	5891	-608	3926
UTP6	3752	1891	-2359	3932
WDR12	2088	2282	-541	6792
WDR18	-2689	2119	-1828	-1077
WDR3	-11	550	-3655	-1385
WDR36	2325	4898	-2570	6599
WDR43	1173	2125	-4139	5508
WDR75	2774	3709	-4340	4613
XRN2	1078	2908	3514	-29

---

---

rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol

metric	value
setSize	154
pMANOVA	8.88e-34
p.adjustMANOVA	1.72e-31
s.dist	0.601
s.t0_crp_RNA	-0.247
s.t0_crp_meth	-0.0604
s.pod_crp_RNA	-0.528
s.pod_crp_meth	0.133
p.t0_crp_RNA	1.42e-07
p.t0_crp_meth	0.198
p.pod_crp_RNA	1.5e-29
p.pod_crp_meth	0.00457

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
FBL	-4594	-4678
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RRP9	-3731	-4587
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
EXOSC2	-3761	-3836
RPS10	-3457	-4168
EXOSC5	-3823	-3756
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
BMS1	-1273	279	-4313	-1753
BYSL	-2328	5900	-2573	6806
C1D	4279	3651	206	2322
CSNK1D	-4441	6564	2787	3046
CSNK1E	-3951	7015	-3414	3000
DCAF13	-562	1410	-1783	862
DDX21	2972	7462	-1540	3312
DDX47	4326	892	-3647	-50
DDX49	-4479	3907	1633	5580
DDX52	4531	3595	579	-204
DHX37	-3145	6236	-2526	4194
DIS3	4375	4884	-1622	-754
EBNA1BP2	-556	1401	-3067	6233
ERI1	3766	-203	768	-139
EXOSC1	2149	7237	992	316
EXOSC10	1827	1777	-2188	802
EXOSC2	-3836	-378	-3761	5343
EXOSC3	851	4957	110	3245
EXOSC4	-2860	5195	3343	64
EXOSC5	-3756	469	-3823	790
EXOSC6	-1352	3467	-3661	1534
EXOSC7	-4443	4094	-2938	-158
EXOSC8	3032	5356	-3616	1364
FAU	-4223	5971	-437	6875
FBL	-4678	-91	-4594	-43
FCF1	2808	5725	-1239	6761
FTSJ3	-2540	4963	1385	4235
GAR1	-224	3758	-2986	879
GNL3	2241	1853	-4428	1201
HEATR1	566	6362	-3326	5200
IMP3	-1621	6086	-3137	5540
IMP4	-2501	4256	-3803	3786
ISG20L2	530	2755	-15	6436
KRR1	2893	-801	-2865	-1950
LTV1	2852	2898	-1941	2915
MPHOSPH10	4488	5449	-2942	5400
MPHOSPH6	1961	6222	-949	5533
NCL	-1980	6791	-4315	5053
NHP2	-3191	6971	-2519	4826
NIP7	1970	5730	-3733	4218
NOB1	-2719	-262	-4364	2003
NOC4L	-1413	5509	2788	-799
NOL11	3694	-390	-4414	2571
NOL12	-297	5999	2186	-1549
NOL6	-4372	6081	-3107	4556
NOL9	1673	-787	-3236	-1444
NOP10	-1724	2394	4174	2081
NOP14	-2035	-731	-4619	2209
NOP2	-3532	5036	-2782	6401
NOP56	-390	117	-3865	996
NOP58	3566	2112	-4420	1333
PDCD11	-2808	1973	-3660	3455
PELP1	-637	6658	-3306	2742
PES1	-4103	222	-2386	3288
PNO1	2611	1456	-3399	6494
PWP2	-3288	3400	-3239	5075
RBM28	-2460	5591	-2557	3412
RCL1	-2020	7155	-3537	6341
RIOK1	2656	7804	-1376	6496
RIOK2	3564	1632	-3897	1638
RIOK3	3495	2135	1073	3472
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPP14	3290	6084	-993	2236
RPP21	-3292	6702	-86	2599
RPP25	-2510	7139	-3453	5743
RPP30	3476	4936	-3223	668
RPP38	3369	1308	-2914	4779
RPP40	1457	2935	-4562	570
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
RRP1	-894	4246	340	5199
RRP7A	-281	3244	-1932	1582
RRP9	-4587	-253	-3731	653
SENP3	-1093	8054	1649	5393
SNU13	-1800	-638	-3664	7052
TBL3	-3751	5261	19	5417
TEX10	3497	-297	-4086	1204
THUMPD1	3126	1431	-4395	-871
TRMT112	-4008	7769	-160	1929
TSR1	-341	6406	-4621	6837
TSR3	-4199	1625	-151	6368
UBA52	-3208	4386	-596	-69
UTP15	4103	2192	-3831	5062
UTP18	1555	4515	1472	3357
UTP20	2389	4984	-3079	5084
UTP3	-823	5891	-608	3926
UTP6	3752	1891	-2359	3932
WDR12	2088	2282	-541	6792
WDR18	-2689	2119	-1828	-1077
WDR3	-11	550	-3655	-1385
WDR36	2325	4898	-2570	6599
WDR43	1173	2125	-4139	5508
WDR75	2774	3709	-4340	4613
XRN2	1078	2908	3514	-29

---

---

Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol

metric	value
setSize	147
pMANOVA	3.3e-33
p.adjustMANOVA	5.48e-31
s.dist	0.609
s.t0_crp_RNA	-0.239
s.t0_crp_meth	-0.067
s.pod_crp_RNA	-0.54
s.pod_crp_meth	0.135
p.t0_crp_RNA	6.34e-07
p.t0_crp_meth	0.163
p.pod_crp_RNA	1.54e-29
p.pod_crp_meth	0.00504

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
FBL	-4594	-4678
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RRP9	-3731	-4587
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
EXOSC2	-3761	-3836
RPS10	-3457	-4168
EXOSC5	-3823	-3756
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
BMS1	-1273	279	-4313	-1753
BYSL	-2328	5900	-2573	6806
C1D	4279	3651	206	2322
CSNK1D	-4441	6564	2787	3046
CSNK1E	-3951	7015	-3414	3000
DCAF13	-562	1410	-1783	862
DDX21	2972	7462	-1540	3312
DDX47	4326	892	-3647	-50
DDX49	-4479	3907	1633	5580
DDX52	4531	3595	579	-204
DHX37	-3145	6236	-2526	4194
DIS3	4375	4884	-1622	-754
EBNA1BP2	-556	1401	-3067	6233
ERI1	3766	-203	768	-139
EXOSC1	2149	7237	992	316
EXOSC10	1827	1777	-2188	802
EXOSC2	-3836	-378	-3761	5343
EXOSC3	851	4957	110	3245
EXOSC4	-2860	5195	3343	64
EXOSC5	-3756	469	-3823	790
EXOSC6	-1352	3467	-3661	1534
EXOSC7	-4443	4094	-2938	-158
EXOSC8	3032	5356	-3616	1364
FAU	-4223	5971	-437	6875
FBL	-4678	-91	-4594	-43
FCF1	2808	5725	-1239	6761
FTSJ3	-2540	4963	1385	4235
GNL3	2241	1853	-4428	1201
HEATR1	566	6362	-3326	5200
IMP3	-1621	6086	-3137	5540
IMP4	-2501	4256	-3803	3786
ISG20L2	530	2755	-15	6436
KRR1	2893	-801	-2865	-1950
LTV1	2852	2898	-1941	2915
MPHOSPH10	4488	5449	-2942	5400
MPHOSPH6	1961	6222	-949	5533
NCL	-1980	6791	-4315	5053
NIP7	1970	5730	-3733	4218
NOB1	-2719	-262	-4364	2003
NOC4L	-1413	5509	2788	-799
NOL11	3694	-390	-4414	2571
NOL12	-297	5999	2186	-1549
NOL6	-4372	6081	-3107	4556
NOL9	1673	-787	-3236	-1444
NOP14	-2035	-731	-4619	2209
NOP56	-390	117	-3865	996
NOP58	3566	2112	-4420	1333
PDCD11	-2808	1973	-3660	3455
PELP1	-637	6658	-3306	2742
PES1	-4103	222	-2386	3288
PNO1	2611	1456	-3399	6494
PWP2	-3288	3400	-3239	5075
RBM28	-2460	5591	-2557	3412
RCL1	-2020	7155	-3537	6341
RIOK1	2656	7804	-1376	6496
RIOK2	3564	1632	-3897	1638
RIOK3	3495	2135	1073	3472
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPP14	3290	6084	-993	2236
RPP21	-3292	6702	-86	2599
RPP25	-2510	7139	-3453	5743
RPP30	3476	4936	-3223	668
RPP38	3369	1308	-2914	4779
RPP40	1457	2935	-4562	570
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
RRP1	-894	4246	340	5199
RRP7A	-281	3244	-1932	1582
RRP9	-4587	-253	-3731	653
SENP3	-1093	8054	1649	5393
SNU13	-1800	-638	-3664	7052
TBL3	-3751	5261	19	5417
TEX10	3497	-297	-4086	1204
TSR1	-341	6406	-4621	6837
UBA52	-3208	4386	-596	-69
UTP15	4103	2192	-3831	5062
UTP18	1555	4515	1472	3357
UTP20	2389	4984	-3079	5084
UTP3	-823	5891	-608	3926
UTP6	3752	1891	-2359	3932
WDR12	2088	2282	-541	6792
WDR18	-2689	2119	-1828	-1077
WDR3	-11	550	-3655	-1385
WDR36	2325	4898	-2570	6599
WDR43	1173	2125	-4139	5508
WDR75	2774	3709	-4340	4613
XRN2	1078	2908	3514	-29

---

---

Selenocysteine synthesis

Selenocysteine synthesis

metric	value
setSize	68
pMANOVA	4.67e-32
p.adjustMANOVA	6.78e-30
s.dist	0.876
s.t0_crp_RNA	-0.585
s.t0_crp_meth	-0.0658
s.pod_crp_RNA	-0.622
s.pod_crp_meth	0.184
p.t0_crp_RNA	7.35e-17
p.t0_crp_meth	0.349
p.pod_crp_RNA	7.45e-19
p.pod_crp_meth	0.00882

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938
RPS23	-3858	-3376
RPL38	-2941	-4417

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
EEFSEC	-2212	6213	-2244	1972
FAU	-4223	5971	-437	6875
PSTK	-1027	7764	-1264	-729
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
SEPHS2	-23	4118	2705	1949
UBA52	-3208	4386	-596	-69

---

---

Viral mRNA Translation

Viral mRNA Translation

metric	value
setSize	67
pMANOVA	1.62e-31
p.adjustMANOVA	2.09e-29
s.dist	0.876
s.t0_crp_RNA	-0.569
s.t0_crp_meth	-0.0815
s.pod_crp_RNA	-0.623
s.pod_crp_meth	0.22
p.t0_crp_RNA	7.86e-16
p.t0_crp_meth	0.25
p.pod_crp_RNA	1.18e-18
p.pod_crp_meth	0.00189

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938
RPS23	-3858	-3376
RPL38	-2941	-4417

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
DNAJC3	2858	8289	3092	6470
FAU	-4223	5971	-437	6875
GRSF1	1523	1467	-1290	4315
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
UBA52	-3208	4386	-596	-69

---

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

metric	value
setSize	70
pMANOVA	2.46e-31
p.adjustMANOVA	2.86e-29
s.dist	0.852
s.t0_crp_RNA	-0.564
s.t0_crp_meth	-0.0815
s.pod_crp_RNA	-0.613
s.pod_crp_meth	0.158
p.t0_crp_RNA	3.47e-16
p.t0_crp_meth	0.239
p.pod_crp_RNA	7.08e-19
p.pod_crp_meth	0.0224

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938
RPS23	-3858	-3376
RPL38	-2941	-4417

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
APEH	-3872	429	1730	832
ETF1	3017	7097	1676	151
FAU	-4223	5971	-437	6875
GSPT1	2757	4351	-2932	-1153
N6AMT1	96	323	-4168	62
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
TRMT112	-4008	7769	-160	1929
UBA52	-3208	4386	-596	-69

---

---

Innate Immune System

Innate Immune System

metric	value
setSize	616
pMANOVA	2.03e-30
p.adjustMANOVA	2.14e-28
s.dist	0.288
s.t0_crp_RNA	-0.0105
s.t0_crp_meth	-0.00718
s.pod_crp_RNA	0.287
s.pod_crp_meth	0.00104
p.t0_crp_RNA	0.662
p.t0_crp_meth	0.766
p.pod_crp_RNA	4.7e-33
p.pod_crp_meth	0.966

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
PELI3	4288	-4660
NLRX1	4251	-4356
ITGB2	4253	-4211
LAMTOR1	3758	-4534
MAPK3	3649	-4620
VAT1	4292	-3926
AGPAT2	4455	-3761
ALAD	4014	-4161
STK11IP	3990	-4178
TOM1	4227	-3899
AP1M1	3873	-4217
DBNL	3614	-4518
PDAP1	3697	-4405
DNM2	3699	-4239
IGF2R	3850	-4041
CAPN1	3918	-3906
CYB5R3	3732	-4015
DTX4	3400	-4129
LAMTOR2	3497	-3989
SNAP29	3209	-4308

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
A1BG	-4720	7280	525	567
AAMP	-4607	1163	-1372	7118
ABI1	4121	520	2868	3253
ABI2	570	1453	-3567	-206
ABL1	-3241	5957	1585	2469
ACAA1	-1087	6265	4528	5788
ACLY	-1395	2347	3652	2976
ACTB	-373	4248	4005	5446
ACTG1	-3456	6407	3191	1603
ACTR10	2603	5113	1646	4867
ACTR1B	-3875	3798	-2148	2629
ACTR2	3144	4932	2747	3844
ACTR3	2753	4481	2482	5950
ADAM10	2914	3590	3423	2760
ADAM8	-2204	7454	2256	5096
ADGRE5	-2627	2052	3671	-1468
AGA	-2883	-401	-2619	2162
AGL	2065	2754	-959	1016
AGPAT2	-3761	-328	4455	-1386
AHCYL1	1297	6888	1605	2692
AIM2	2677	-558	720	-1275
ALAD	-4161	371	4014	1057
ALDOA	-1859	643	4238	5366
ALDOC	-367	7284	-2691	65
ALOX5	330	6127	4345	5385
AMPD3	-1687	4553	3545	3216
ANO6	-849	7646	-21	1102
AP1M1	-4217	2143	3873	1777
APAF1	1473	7512	2266	-809
APEH	-3872	429	1730	832
APP	-1029	7569	1303	6621
APRT	-4283	7658	-2811	2643
ARHGAP9	-2519	389	4113	6255
ARL8A	-3571	135	3462	-1057
ARMC8	3399	4263	67	2641
ARPC1B	-3236	2831	4244	1709
ARPC2	1775	5683	3457	2292
ARPC3	2785	4820	3580	3208
ARPC5	2109	2335	3836	2611
ARSA	1972	-580	3635	523
ARSB	1416	6851	3997	-1526
ASAH1	2991	3487	4461	2174
ATAD3B	-3224	5569	-2736	4810
ATF1	4365	685	1579	2989
ATG12	4083	4620	-2436	6821
ATG5	4418	1135	-2277	-680
ATG7	2082	1256	2282	3847
ATOX1	-2402	7999	2468	390
ATP11A	-1708	5464	4170	132
ATP11B	1100	-213	1786	-241
ATP6V0A1	-73	5522	4481	-1569
ATP6V0A2	1039	5229	-2100	6651
ATP6V0B	-2906	4920	4040	5502
ATP6V0C	-819	2497	4204	2933
ATP6V0D1	-717	5801	4411	6934
ATP6V0E1	-98	5534	3098	1836
ATP6V0E2	688	-8	-3868	-1325
ATP6V1A	2260	3916	3165	-1495
ATP6V1B2	1335	2965	3679	-1553
ATP6V1C1	3195	3435	3307	6757
ATP6V1D	3158	446	3682	1096
ATP6V1E1	3127	6210	2844	4775
ATP6V1F	-2969	2955	1967	-699
ATP6V1G2	-783	7744	-3696	3740
ATP6V1H	2094	5695	1932	2559
ATP8A1	-1321	-197	-4498	-913
ATP8B4	80	-467	612	-1099
B2M	3496	3645	-3314	-9
B4GALT1	-2606	7929	1953	7041
BAIAP2	-3214	6287	-510	2757
BCL10	3129	6246	1603	2575
BCL2	891	55	-3102	7020
BCL2L1	168	5903	-129	5968
BIN2	-3373	3302	4006	5389
BIRC2	4449	4494	-741	6624
BIRC3	3504	588	-4618	4816
BRI3	-1874	3754	4413	-1176
BRK1	-4091	8027	-825	3071
BST2	1250	-703	383	-1933
BTRC	-2069	66	-3130	-923
C3AR1	4000	1722	4547	-1594
C6orf120	-845	7883	319	3829
C8G	-1876	4665	114	-1364
CAB39	2427	-206	2233	7106
CALM1	1287	3980	-2201	4501
CAND1	2021	1725	-3244	2163
CAP1	497	5559	3138	2034
CAPN1	-3906	5471	3918	1819
CAPZA1	4166	7801	2992	999
CAPZA2	3798	3735	2976	4666
CARD11	-3851	5791	-4243	6542
CARD9	-3315	-774	3670	-1761
CASP1	4199	-379	2331	7029
CASP10	2029	1610	1690	-1805
CASP4	3211	507	2271	-96
CASP8	2071	5784	-2229	5447
CASP9	110	698	4367	3202
CAT	282	-220	3549	-1204
CCT2	1454	3443	-4591	194
CCT8	2610	2003	-111	2904
CD247	-4182	3160	-4496	6034
CD300A	2225	-861	4103	-1998
CD4	-528	5984	-2076	909
CD44	498	4392	3154	4897
CD46	4402	5368	2807	5538
CD47	2166	2442	-3816	6601
CD53	2247	-462	3926	6482
CD55	1738	3285	4145	1455
CD58	4062	5810	3835	-611
CD59	-1703	4468	-1328	-1682
CD63	-2910	7177	4520	5433
CD81	-2406	2412	-2059	3296
CDC34	-4179	6224	2873	-408
CDC42	3320	7040	2741	856
CDK13	-2241	5468	9	5777
CEACAM1	-237	822	1684	5458
CEP290	4268	7316	-2743	7000
CFL1	-3249	4059	3672	1646
CHUK	2695	2702	2681	1111
CKAP4	-813	8287	3854	-987
CMTM6	3583	4072	2869	1926
CNN2	-1565	2034	1954	-418
CNPY3	-2430	3188	3017	1242
COMMD3	3610	606	665	-1960
COMMD9	1680	85	3383	2239
COPB1	4354	2889	2313	2637
COTL1	671	2421	4276	6759
CPNE1	-1872	4807	-478	5131
CPNE3	1598	2499	-94	-1441
CPPED1	340	5747	4044	-641
CRCP	998	6155	1033	4707
CREB1	2387	5046	-1542	1422
CREBBP	-4011	6807	2122	892
CREG1	-2492	1563	2917	-1059
CRK	3068	5936	3523	6596
CSNK2B	63	7476	2450	4742
CSTB	469	6900	4229	2893
CTNNB1	2009	6708	3025	5069
CTSA	-2481	2086	4047	2720
CTSB	83	7057	4475	-965
CTSC	2238	2310	3599	1311
CTSD	-3067	8404	4479	6620
CTSL	873	8363	4377	3028
CTSS	2274	-506	2686	-1544
CTSV	-308	7141	-258	5169
CTSZ	-1191	-74	4162	-1978
CUL1	4355	1572	-4161	-1190
CYB5R3	-4015	4980	3732	3239
CYBA	-2911	5359	4087	2019
CYFIP1	644	8297	4331	256
CYFIP2	-1585	4227	-2032	6157
CYLD	1079	5350	-4487	5704
CYSTM1	594	7301	3572	-1740
DBNL	-4518	2964	3614	-406
DDX41	-4055	5715	1011	4425
DDX58	4465	2907	-3747	185
DEGS1	-1317	4783	-164	3203
DERA	3518	7409	3669	3602
DGAT1	-3399	6428	2057	-576
DHX36	3868	1789	-1657	6438
DHX58	3998	1444	-1341	-30
DHX9	243	6405	-2418	5545
DIAPH1	-659	5118	910	2371
DNAJC13	3873	207	3651	408
DNAJC3	2858	8289	3092	6470
DNAJC5	-2985	3110	3776	-1396
DNM1	2874	2154	2211	1607
DNM2	-4239	6583	3699	3063
DPP7	-4644	7245	-1735	6584
DSN1	2407	2698	-1398	-996
DTX4	-4129	5372	3400	5143
DUSP3	-328	6561	3398	2260
DUSP4	1176	3581	-1089	2494
DUSP6	-534	7727	-1313	-1941
DUSP7	-2585	6442	-1315	722
DYNC1H1	-2872	1165	-441	4433
DYNC1LI1	3353	6061	2935	3242
DYNLL1	-405	5371	1250	5150
DYNLT1	2953	4660	2802	5599
ECSIT	-1973	6302	1201	1450
EEA1	3244	1440	-457	5334
EEF1A1	-3462	2007	-4432	2941
EEF2	-4680	1309	-3170	4195
ELMO1	-2007	4440	-587	939
ELMO2	2276	3622	3753	6108
ENPP4	1515	1338	-2234	3170
EP300	-1082	3351	3310	4900
ERP44	3533	127	1159	920
FABP5	1248	3657	2416	2233
FADD	-32	2272	2169	-329
FAF2	230	7630	1614	2842
FBXW11	-1449	8406	480	-1506
FGR	-1601	6431	4539	-1074
FOS	-4562	4067	-1568	5645
FTH1	-378	3718	2380	3117
FTL	609	3955	3972	-1424
FUCA1	-689	2325	2425	1656
FUCA2	1128	614	2428	-1234
FYN	-2118	2799	-2956	2793
GAA	-1924	1082	3079	2768
GAB2	-2692	347	3912	2390
GALNS	-2319	6550	3709	3670
GCA	3226	2697	4151	5559
GDI2	3001	7874	2004	3343
GGH	2821	6701	1044	3861
GHDC	-3703	2847	1243	-571
GLB1	890	7186	4196	1828
GLIPR1	3846	390	2195	5591
GM2A	2719	6404	4388	6361
GMFG	254	6320	3611	6367
GNS	1404	5454	4533	4428
GOLGA7	1327	3410	-2030	3104
GPI	-2280	6574	1799	5672
GRAP2	-2746	6230	-2761	3631
GRB2	29	5972	4230	6239
GRN	-475	3078	4312	4937
GSDMD	-2417	4172	1671	-91
GSTP1	-976	6809	683	-1350
GUSB	-2488	4868	4470	2338
GYG1	-319	6447	3938	-231
GZMM	-3093	-219	-3628	7249
HEBP2	-1887	5561	2156	552
HERC5	4477	1222	-3630	-1037
HEXB	1519	7559	2594	2906
HGSNAT	-63	352	-1489	3342
HLA-A	-4080	2266	-2368	-1093
HLA-B	-821	510	896	-730
HLA-C	51	6767	1218	4448
HLA-E	-950	3730	-1002	5634
HLA-H	-4350	7821	-546	4988
HMGB1	1943	2521	-3489	3222
HMOX2	-3769	699	-4339	6411
HRAS	-3453	1483	-1282	-823
HSP90AA1	3100	4857	-2176	6208
HSP90AB1	1227	824	-4305	-1224
HSP90B1	4301	7702	-1893	2127
HSPA1A	-3490	1106	2517	-920
HSPA1B	1576	750	1718	655
HVCN1	-951	1427	1485	-385
ICAM2	-608	980	-4564	4818
ICAM3	-4729	900	2016	6838
IDH1	3628	3280	4526	3454
IFIH1	4466	4707	-2544	2681
IGF2R	-4041	-23	3850	-1657
IKBKB	-1861	958	1970	-912
IKBKE	-39	5956	3231	6703
ILF2	2531	-350	-1689	2770
IMPDH1	-1286	6	4428	2600
IMPDH2	-3789	5334	-4679	250
IQGAP1	-6	372	3381	587
IQGAP2	2140	2768	3344	3888
IRAK2	-3547	7809	-2980	4685
IRAK3	1420	2776	4357	666
IRF3	-2649	2791	-1301	4240
IRF7	2494	6595	3230	3556
ISG15	3651	-537	-3046	6539
IST1	2520	1926	2863	1014
ITCH	421	6841	732	4853
ITGAL	-1994	4404	1129	7036
ITGAV	2010	3274	3023	-370
ITGB2	-4211	745	4253	6424
ITK	-839	-349	-4350	-1699
ITPR1	-1901	6612	-1565	1789
ITPR2	1162	4456	2298	-44
ITPR3	-748	2875	-2503	2189
JUN	-3724	2763	-598	1283
KCMF1	1322	-488	1586	3310
KCNAB2	-4643	5909	2760	-600
KPNB1	2659	5901	-47	1140
KRAS	4442	4004	1217	3139
LAIR1	-901	6730	4482	3425
LAMP1	-4014	7954	3219	2553
LAMTOR1	-4534	-643	3758	-1587
LAMTOR2	-3989	-286	3497	-1340
LAMTOR3	3368	6744	792	957
LAT2	-1732	6599	4173	-1714
LCK	-1825	2493	-4488	7243
LCP2	2815	-273	200	-428
LGMN	-2484	6373	-3917	2706
LIMK1	-3358	-627	3471	-1748
LPCAT1	-2710	-419	1992	1418
LRRFIP1	3522	4814	3045	5296
LTA4H	2233	5699	4301	798
MALT1	633	7648	-4558	2545
MAN2B1	-2647	7254	2518	6387
MANBA	3782	4762	2996	6844
MAP2K1	-1421	-148	3921	1533
MAP2K3	-2498	38	3714	2411
MAP2K4	1784	3155	1767	4763
MAP2K6	3151	2164	3939	4791
MAP2K7	-4193	2092	431	1764
MAP3K1	1458	3815	1771	2247
MAP3K14	-2001	1381	-3221	4220
MAP3K7	2692	3839	1057	-147
MAP3K8	826	6359	4551	3266
MAPK1	-745	2758	4197	6097
MAPK14	1563	2227	4024	2465
MAPK3	-4620	-475	3649	1978
MAPK7	-2209	3007	3966	-244
MAPK8	-1037	6156	-3737	4553
MAPK9	-260	1152	-2605	157
MAPKAPK2	-3939	1416	2421	3265
MAPKAPK3	-1142	58	4580	2896
MAVS	-3312	5447	2245	4280
MEF2A	2271	7441	3276	3013
MIF	-3715	2437	-3047	3355
MLEC	-1358	5314	-1498	2183
MMP25	-966	6396	4100	6852
MNDA	3361	1442	3506	-1994
MPO	-3878	344	-3645	-1967
MUC1	-1022	6782	2987	6713
MUC12	3257	3997	-166	4640
MUC5B	758	-829	2510	-1743
MVP	-3502	7998	3433	6953
MYD88	1536	2750	4540	1945
MYH9	-3635	3380	2352	6144
MYO9B	-2080	3138	4362	6775
NAPRT	214	-73	4098	-1869
NBEAL2	-2403	5606	4127	1726
NCF4	-2178	-141	4210	-1939
NCK1	3861	1096	-4123	1018
NCKAP1L	650	1928	4458	-320
NCKIPSD	-3678	7993	-3134	667
NCSTN	1556	-453	4578	1224
NDUFC2	-2586	5313	2549	2881
NEU1	660	3057	4459	1899
NF2	54	981	522	1410
NFATC1	-3266	6729	-1906	6945
NFATC2	-2966	5180	-4600	7156
NFATC3	514	4876	-3772	1668
NFKB2	-128	2515	499	5250
NFKBIA	-1959	3670	1551	6812
NFKBIB	-4043	4651	2779	5572
NHLRC3	3852	5873	2633	4505
NIT2	2452	1153	-3459	-141
NKIRAS1	-1254	4201	-3568	348
NKIRAS2	-2892	2008	4410	-1130
NLRC5	-108	-233	1147	1905
NLRP1	-1719	7053	-761	3033
NLRP3	-16	6382	3342	-847
NLRX1	-4356	-359	4251	768
NME2	1390	1732	-173	-880
NOD1	702	2037	268	-321
NOD2	948	2355	4498	6608
NOS3	929	4038	-3056	4048
NPC2	2405	6347	2830	2198
ORMDL3	-3219	2570	-3756	3085
OSCAR	1666	2313	4583	7120
OSTF1	1009	7525	2469	6468
P2RX1	2272	2764	4586	-1947
PA2G4	1938	2826	-2412	5242
PAFAH1B2	2330	4486	909	2435
PAK1	3393	4953	4129	2452
PAK2	3060	2498	2198	283
PANX1	894	1287	2763	3960
PCBP2	-2726	1016	-881	3201
PDAP1	-4405	8096	3697	2952
PDPK1	-3330	144	2187	346
PDXK	-1102	4954	2867	1492
PELI1	829	1534	725	1867
PELI2	-80	8419	1276	7033
PELI3	-4660	3884	4288	-1121
PFKL	-4475	23	464	-1730
PGAM1	-1229	1586	4418	1307
PGM1	-3622	4559	1829	776
PGM2	1298	3342	3609	5133
PIK3CA	2884	3277	-475	1470
PIK3R1	-2132	5137	-4392	6991
PIK3R2	-2279	5345	2344	3831
PIK3R4	2189	2075	-1855	2170
PIN1	-4611	3766	76	4014
PKM	-1111	1474	4062	3231
PLA2G6	-4368	2559	-2235	826
PLAC8	-1486	3803	4406	1235
PLAU	-1912	5281	914	-1527
PLAUR	226	4310	4189	-861
PLCG1	-749	5789	-3949	958
PLCG2	-1458	6158	3982	2803
PLD1	2370	2188	4049	-902
PLD3	-2550	2237	2394	354
PLEKHO2	703	6284	4254	6697
PNP	823	2158	3217	3516
POLR1C	2228	2648	-3560	5328
POLR1D	804	3932	385	6780
POLR2E	-4070	2983	1998	3712
POLR2F	-4130	6520	2177	509
POLR2H	-1987	7555	-1495	6297
POLR2K	3699	2452	-1615	3853
POLR3A	386	3837	301	5225
POLR3C	3386	7974	466	3978
POLR3D	-2976	180	-3773	1967
POLR3E	-4047	6433	-3136	1113
POLR3F	3336	7901	-2866	-1022
POLR3G	587	7022	-3591	6659
POLR3GL	192	230	-854	204
POLR3H	-4544	6311	-4490	5544
POLR3K	926	708	710	891
PPIA	-239	5602	-1924	4554
PPIE	1995	6743	-2167	6025
PPP2CA	2133	7688	1877	2598
PPP2CB	3173	15	2037	2771
PPP2R1B	1368	607	-1191	6169
PPP2R5D	-1009	5720	986	3470
PPP3CA	-123	1244	-187	5978
PPP3CB	4151	5256	913	4044
PPP3R1	579	5005	124	2945
PRCP	2944	6346	2835	611
PRDX6	-1247	4144	-345	5477
PRKACA	-1378	3969	4529	890
PRKACB	559	7713	-4630	1712
PRKCD	301	8167	4500	6358
PRKCE	-1194	7105	3475	-1183
PRKCQ	-1185	3922	-4577	4207
PRKCSH	-4486	5300	2163	4697
PRKDC	-1551	8114	-2256	6474
PRTN3	-4653	8354	-2832	5619
PSAP	506	1283	3823	628
PSEN1	2104	1717	4209	4954
PSMA1	2917	5206	1363	4758
PSMA2	1509	4929	-836	5163
PSMA3	4416	1432	-1823	3586
PSMA5	3047	4175	-2828	3319
PSMA6	3897	6144	1661	6676
PSMA7	-246	5863	3266	6901
PSMB1	-371	2981	-803	5409
PSMB10	-3433	689	-161	6388
PSMB2	835	-501	1803	1518
PSMB3	23	780	3778	4305
PSMB5	-2694	183	3229	269
PSMB6	-3103	5638	3472	5817
PSMB7	-2378	1587	2955	4198
PSMB8	949	1746	2054	5155
PSMB9	-217	3058	-3454	4468
PSMC1	928	2242	2194	1413
PSMC3	-2624	4680	847	736
PSMC4	-1230	1188	537	3431
PSMC5	-1694	2039	-2600	5094
PSMC6	4108	118	1373	2356
PSMD1	2911	5546	2375	56
PSMD11	4009	2032	2637	3521
PSMD12	4511	5250	2167	3681
PSMD13	-998	7807	1482	561
PSMD14	3360	3896	85	6314
PSMD2	-3334	6719	2097	3610
PSMD3	-4637	3063	1629	5579
PSMD4	-1530	1685	3940	5313
PSMD6	1854	3171	3275	2336
PSMD7	3595	864	596	2079
PSMD8	-2435	7747	2069	4665
PSMD9	-3510	-186	3384	3375
PSME1	1353	7210	-2849	1614
PSME2	3304	7208	-1478	778
PSME3	802	6539	2470	5231
PSME4	3349	7885	-461	5908
PSMF1	-1946	2260	416	7179
PSTPIP1	-3181	2316	4195	680
PTGES2	-4318	-433	-1375	-901
PTK2	-814	2487	-1377	-475
PTPN11	-256	3762	1122	5061
PTPN4	-398	1836	-4481	784
PTPN6	-1174	2534	4395	6540
PTPRC	3660	1759	2823	-936
PTPRJ	-2062	6860	3552	7167
PTPRN2	-1502	1639	-965	6583
PYCARD	-1515	3142	4319	-1818
PYGB	-3390	-229	-1259	141
QPCT	1033	1841	3998	-1472
QSOX1	-2300	6788	4519	5725
RAB10	2203	1022	4224	3067
RAB14	3720	1861	1150	-378
RAB18	4478	1161	1696	2764
RAB24	1932	257	4083	-168
RAB27A	3269	7260	2952	222
RAB37	-1677	7528	-2789	409
RAB3A	-4569	3507	482	4347
RAB3D	604	5944	3885	1148
RAB4B	-2727	7770	3909	4687
RAB5B	-516	1208	1896	1957
RAB5C	-2850	2984	3898	797
RAB6A	3034	6426	2839	3323
RAB7A	837	-522	3489	-124
RAC1	3574	7484	4225	5539
RAC2	-3760	6815	1945	4576
RAF1	537	4277	3739	6571
RAP1A	4512	2607	2624	6567
RAP1B	2749	6134	2033	5966
RAP2B	-283	6562	394	5291
RASGRP1	500	3237	-4511	5886
RASGRP2	-3881	4893	-1986	-413
RBSN	-2650	7872	-1916	6352
RELA	-4376	5729	-1050	4332
RELB	-1928	4179	2626	577
RHOA	2796	1879	3280	4033
RHOF	-3403	3511	-4235	6476
RHOG	-703	3967	4093	3664
RIPK3	1097	1791	4431	6793
RNASET2	-1180	732	3304	7087
RNF125	-499	4923	-4473	6174
RNF135	1671	2669	4476	-1613
RNF216	-3207	1260	-3286	4490
ROCK1	4037	2208	2623	2732
RPS27A	-3731	2481	-4078	2589
RPS6KA1	-2393	6272	4241	-1857
RPS6KA2	-3185	6436	-715	2117
RPS6KA5	4173	7351	-3252	1991
S100A11	1465	3952	4310	6087
S100P	-3641	627	3560	3303
SARM1	-3359	8141	-3432	4841
SCAMP1	2598	7802	-3481	2645
SDCBP	3311	7419	3605	3834
SERPINB1	990	-241	4236	-1477
SERPINB6	-3927	7977	3455	2823
SHC1	47	7294	2954	3205
SIGIRR	-3514	8336	-2448	6805
SIKE1	3833	950	-2073	1675
SKP1	3454	3180	-2543	2680
SLC11A1	-326	1277	4588	4001
SLC15A4	-384	-645	3676	-1575
SLC27A2	3534	3271	-3276	-1409
SLC2A3	-2653	4133	3706	-1209
SLC44A2	-3555	1449	11	4322
SLCO4C1	838	1673	1214	-99
SNAP23	2642	7973	1694	-471
SNAP29	-4308	6060	3209	3148
SOCS1	3263	5646	2492	4130
SOS1	3053	3267	-1345	-1984
SPTAN1	-4171	369	-4508	-407
SRC	-1769	-92	-2399	-1474
SRP14	2388	5802	1918	5762
STAT6	-2092	3383	4260	3854
STBD1	785	6119	-200	-658
STK10	-3634	3470	2725	-688
STK11IP	-4178	4530	3990	2122
STOM	312	-756	1358	-1584
SUGT1	3689	6377	-97	5004
SURF4	-2330	5219	1962	3679
SVIP	2044	4128	-3340	1104
SYK	927	3885	3853	431
TAB2	1280	-849	-1462	6399
TANK	4486	5680	3220	6237
TAX1BP1	4184	1932	1345	1037
TBC1D10C	-4516	3143	-3275	6910
TBK1	4522	6493	2094	599
TCIRG1	-2526	4545	4576	1353
TEC	1638	2871	4185	170
TICAM1	-372	1210	3650	1060
TIFA	1152	8170	-1422	4847
TIRAP	-1492	3362	2573	1661
TLR1	2786	2626	3278	-1111
TLR2	3806	6774	4156	4128
TLR3	605	6769	-4494	2949
TLR5	1902	3910	4264	5699
TLR6	1146	-591	2855	-1199
TLR9	-3285	-405	-837	7201
TMBIM1	-3251	2134	3467	-47
TMC6	-3434	1580	-1994	6748
TMEM179B	-176	1544	388	5595
TMEM30A	3654	7686	1750	6658
TMEM63A	-691	1367	-3328	2620
TNFAIP3	-2738	1870	-572	6103
TNFRSF1B	-1307	1250	4281	6868
TNIP2	-2442	793	2575	287
TOLLIP	-3659	1231	2911	664
TOM1	-3899	5174	4227	4279
TRAF2	40	5279	-2998	5763
TRAF3	-3088	3505	-2224	7206
TRAF6	878	6544	-562	-71
TRAPPC1	-1916	3999	3336	5232
TREX1	1500	2324	592	-1434
TRIM21	3284	-41	2994	-1671
TRIM25	1951	6633	4223	446
TRIM56	1413	2971	-1165	5738
TRPM2	-2751	7757	4355	-1792
TSPAN14	-2003	917	4079	4962
TUBB	-357	3701	-2272	6246
TUBB4B	-2428	6398	2462	7160
TXK	-3364	2757	-4527	4859
TXN	1873	336	3237	-1733
TXNDC5	2037	7500	-1760	-1871
TXNIP	4106	3959	-1903	6152
TYROBP	-1849	830	4152	-1995
UBA3	4072	719	3656	4052
UBA52	-3208	4386	-596	-69
UBA7	-1691	3029	575	-1589
UBB	-2084	561	-996	5058
UBC	-1739	2624	1876	3220
UBE2D1	1930	4687	3454	2741
UBE2D2	-56	4255	-1159	2134
UBE2D3	3202	2444	2392	3005
UBE2K	3615	7162	1074	3260
UBE2L6	2934	760	-3002	1295
UBE2M	-4705	5150	1539	2052
UBE2N	3397	6741	-1303	4833
UBE2V1	2034	4568	-1420	2792
UNC13D	-3097	481	4403	-1904
UNC93B1	100	8116	4277	4748
VAMP8	-2659	3376	1656	868
VAPA	2045	3824	3031	4245
VAT1	-3926	1426	4292	-1357
VAV1	-2612	6923	3874	5832
VAV2	-832	7700	2796	4133
VAV3	-4054	8267	2141	-685
VCL	-1153	1830	476	3614
VCP	-2285	7849	1665	1908
VRK3	1695	5188	2478	2903
VTN	-210	2502	1272	-1925
WASF1	-547	758	4502	-830
WASF2	-2160	1232	3929	-134
WASL	2751	7375	-567	4644
WIPF1	-2325	2893	-1463	-784
WIPF2	655	565	2515	-1017
XRCC5	1691	3512	-1013	1327
XRCC6	661	2803	-3543	3282
YES1	677	-619	-2471	5197
YPEL5	1717	-147	2447	3986
ZBP1	3229	515	-2798	7174

---

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

metric	value
setSize	85
pMANOVA	1.24e-29
p.adjustMANOVA	1.2e-27
s.dist	0.757
s.t0_crp_RNA	-0.472
s.t0_crp_meth	-0.0541
s.pod_crp_RNA	-0.558
s.pod_crp_meth	0.19
p.t0_crp_RNA	5.85e-14
p.t0_crp_meth	0.39
p.pod_crp_RNA	6.43e-19
p.pod_crp_meth	0.00246

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
EIF3B	-4157	-3948
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
EIF3L	-3540	-4194
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
EIF2S1	3538	6680	-1389	4744
EIF2S2	3430	5111	116	6252
EIF3A	728	186	-641	5853
EIF3B	-3948	-637	-4157	-704
EIF3E	3043	3996	-4004	503
EIF3F	-4699	1781	-1541	1471
EIF3G	-4429	1815	-692	3038
EIF3H	-554	4996	-2590	3706
EIF3I	-3483	2651	-1095	696
EIF3J	3642	3047	-2652	737
EIF3K	-2643	8378	-128	6634
EIF3L	-4194	6675	-3540	2568
EIF3M	3156	7216	-2454	5834
EIF4A1	568	5332	2238	881
EIF4A2	3750	5307	-4415	3601
EIF4B	-2849	3070	-3855	5585
EIF4E	4474	5594	818	6719
EIF4G1	-3029	3207	3785	5764
EIF4H	-4464	3662	2777	-1986
FAU	-4223	5971	-437	6875
PABPC1	1721	3723	-1442	3011
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
UBA52	-3208	4386	-596	-69

---

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

metric	value
setSize	72
pMANOVA	1.02e-28
p.adjustMANOVA	8.69e-27
s.dist	0.808
s.t0_crp_RNA	-0.512
s.t0_crp_meth	-0.0739
s.pod_crp_RNA	-0.586
s.pod_crp_meth	0.206
p.t0_crp_RNA	6.27e-14
p.t0_crp_meth	0.279
p.pod_crp_RNA	8.03e-18
p.pod_crp_meth	0.00258

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938
RPS23	-3858	-3376
RPL38	-2941	-4417

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
EIF4G1	-3029	3207	3785	5764
ETF1	3017	7097	1676	151
FAU	-4223	5971	-437	6875
GSPT1	2757	4351	-2932	-1153
NCBP1	4110	6523	-472	5857
NCBP2	4266	3714	-3787	4776
PABPC1	1721	3723	-1442	3011
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
UBA52	-3208	4386	-596	-69
UPF1	-2902	707	2612	5956

---

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

metric	value
setSize	86
pMANOVA	1.05e-28
p.adjustMANOVA	8.69e-27
s.dist	0.742
s.t0_crp_RNA	-0.451
s.t0_crp_meth	-0.0439
s.pod_crp_RNA	-0.555
s.pod_crp_meth	0.195
p.t0_crp_RNA	5.3e-13
p.t0_crp_meth	0.483
p.pod_crp_RNA	6.36e-19
p.pod_crp_meth	0.00178

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
EIF3B	-4157	-3948
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
EIF3L	-3540	-4194
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
EIF2S1	3538	6680	-1389	4744
EIF2S2	3430	5111	116	6252
EIF3A	728	186	-641	5853
EIF3B	-3948	-637	-4157	-704
EIF3E	3043	3996	-4004	503
EIF3F	-4699	1781	-1541	1471
EIF3G	-4429	1815	-692	3038
EIF3H	-554	4996	-2590	3706
EIF3I	-3483	2651	-1095	696
EIF3J	3642	3047	-2652	737
EIF3K	-2643	8378	-128	6634
EIF3L	-4194	6675	-3540	2568
EIF3M	3156	7216	-2454	5834
EIF4A1	568	5332	2238	881
EIF4A2	3750	5307	-4415	3601
EIF4B	-2849	3070	-3855	5585
EIF4E	4474	5594	818	6719
EIF4G1	-3029	3207	3785	5764
EIF4H	-4464	3662	2777	-1986
EIF5	4129	7119	-179	4312
EIF5B	3653	4185	-2613	4182
FAU	-4223	5971	-437	6875
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
UBA52	-3208	4386	-596	-69

---

---

Selenoamino acid metabolism

Selenoamino acid metabolism

metric	value
setSize	76
pMANOVA	2.14e-27
p.adjustMANOVA	1.66e-25
s.dist	0.767
s.t0_crp_RNA	-0.513
s.t0_crp_meth	-0.0842
s.pod_crp_RNA	-0.538
s.pod_crp_meth	0.166
p.t0_crp_RNA	1.12e-14
p.t0_crp_meth	0.205
p.pod_crp_RNA	5.05e-16
p.pod_crp_meth	0.0124

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938
RPS23	-3858	-3376
RPL38	-2941	-4417

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
AHCY	-4086	1889	-1118	5994
AIMP2	-1469	5991	-1076	5641
CTH	2812	1177	-897	3809
EEF1E1	3841	3253	858	-948
EEFSEC	-2212	6213	-2244	1972
FAU	-4223	5971	-437	6875
GSR	-680	1983	4161	4125
PAPSS1	3740	6202	3664	2272
PSTK	-1027	7764	-1264	-729
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
SCLY	-2800	676	-2589	2139
SEPHS2	-23	4118	2705	1949
TXNRD1	1650	211	3064	-1400
UBA52	-3208	4386	-596	-69

---

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

metric	value
setSize	76
pMANOVA	7.66e-27
p.adjustMANOVA	5.56e-25
s.dist	0.761
s.t0_crp_RNA	-0.48
s.t0_crp_meth	-0.0635
s.pod_crp_RNA	-0.563
s.pod_crp_meth	0.167
p.t0_crp_RNA	5.13e-13
p.t0_crp_meth	0.339
p.pod_crp_RNA	2.2e-17
p.pod_crp_meth	0.012

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938
RPS23	-3858	-3376
RPL38	-2941	-4417

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
ASNS	3401	2234	-2739	-387
ATF3	170	4987	-1185	2814
ATF4	-1467	3832	-425	765
CEBPB	225	2576	4283	337
CEBPG	4212	4992	755	1321
DDIT3	1121	1634	1381	5191
EIF2AK4	-837	6842	-663	2103
EIF2S1	3538	6680	-1389	4744
EIF2S2	3430	5111	116	6252
FAU	-4223	5971	-437	6875
GCN1	-1836	7255	-2919	-1759
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
TRIB3	-565	560	-565	3767
UBA52	-3208	4386	-596	-69

---

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

metric	value
setSize	93
pMANOVA	7.5e-26
p.adjustMANOVA	4.84e-24
s.dist	0.679
s.t0_crp_RNA	-0.408
s.t0_crp_meth	-0.0409
s.pod_crp_RNA	-0.506
s.pod_crp_meth	0.193
p.t0_crp_RNA	1.19e-11
p.t0_crp_meth	0.496
p.pod_crp_RNA	3.4e-17
p.pod_crp_meth	0.00133

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
EIF3B	-4157	-3948
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
EIF3L	-3540	-4194
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
EIF2B1	3618	4999	615	6667
EIF2B2	242	6490	1939	-173
EIF2B3	1210	805	-2084	1141
EIF2B4	-1954	5644	2504	3641
EIF2B5	402	832	-990	5041
EIF2S1	3538	6680	-1389	4744
EIF2S2	3430	5111	116	6252
EIF3A	728	186	-641	5853
EIF3B	-3948	-637	-4157	-704
EIF3E	3043	3996	-4004	503
EIF3F	-4699	1781	-1541	1471
EIF3G	-4429	1815	-692	3038
EIF3H	-554	4996	-2590	3706
EIF3I	-3483	2651	-1095	696
EIF3J	3642	3047	-2652	737
EIF3K	-2643	8378	-128	6634
EIF3L	-4194	6675	-3540	2568
EIF3M	3156	7216	-2454	5834
EIF4A1	568	5332	2238	881
EIF4A2	3750	5307	-4415	3601
EIF4B	-2849	3070	-3855	5585
EIF4E	4474	5594	818	6719
EIF4EBP1	-1882	3825	2028	4397
EIF4G1	-3029	3207	3785	5764
EIF4H	-4464	3662	2777	-1986
EIF5	4129	7119	-179	4312
EIF5B	3653	4185	-2613	4182
FAU	-4223	5971	-437	6875
PABPC1	1721	3723	-1442	3011
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
UBA52	-3208	4386	-596	-69

---

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

metric	value
setSize	93
pMANOVA	7.5e-26
p.adjustMANOVA	4.84e-24
s.dist	0.679
s.t0_crp_RNA	-0.408
s.t0_crp_meth	-0.0409
s.pod_crp_RNA	-0.506
s.pod_crp_meth	0.193
p.t0_crp_RNA	1.19e-11
p.t0_crp_meth	0.496
p.pod_crp_RNA	3.4e-17
p.pod_crp_meth	0.00133

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
EIF3B	-4157	-3948
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
EIF3L	-3540	-4194
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
EIF2B1	3618	4999	615	6667
EIF2B2	242	6490	1939	-173
EIF2B3	1210	805	-2084	1141
EIF2B4	-1954	5644	2504	3641
EIF2B5	402	832	-990	5041
EIF2S1	3538	6680	-1389	4744
EIF2S2	3430	5111	116	6252
EIF3A	728	186	-641	5853
EIF3B	-3948	-637	-4157	-704
EIF3E	3043	3996	-4004	503
EIF3F	-4699	1781	-1541	1471
EIF3G	-4429	1815	-692	3038
EIF3H	-554	4996	-2590	3706
EIF3I	-3483	2651	-1095	696
EIF3J	3642	3047	-2652	737
EIF3K	-2643	8378	-128	6634
EIF3L	-4194	6675	-3540	2568
EIF3M	3156	7216	-2454	5834
EIF4A1	568	5332	2238	881
EIF4A2	3750	5307	-4415	3601
EIF4B	-2849	3070	-3855	5585
EIF4E	4474	5594	818	6719
EIF4EBP1	-1882	3825	2028	4397
EIF4G1	-3029	3207	3785	5764
EIF4H	-4464	3662	2777	-1986
EIF5	4129	7119	-179	4312
EIF5B	3653	4185	-2613	4182
FAU	-4223	5971	-437	6875
PABPC1	1721	3723	-1442	3011
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
UBA52	-3208	4386	-596	-69

---

---

Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication

metric	value
setSize	110
pMANOVA	1.08e-25
p.adjustMANOVA	6.59e-24
s.dist	0.626
s.t0_crp_RNA	-0.321
s.t0_crp_meth	-0.0314
s.pod_crp_RNA	-0.492
s.pod_crp_meth	0.215
p.t0_crp_RNA	6.52e-09
p.t0_crp_meth	0.57
p.pod_crp_RNA	5.69e-19
p.pod_crp_meth	0.000103

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938
RPS23	-3858	-3376
RPL38	-2941	-4417

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
AAAS	-638	2718	243	1467
DNAJC3	2858	8289	3092	6470
FAU	-4223	5971	-437	6875
GRSF1	1523	1467	-1290	4315
GTF2F1	-4236	1342	2079	558
GTF2F2	2000	4258	2006	5306
HSP90AA1	3100	4857	-2176	6208
IPO5	-775	8332	-4676	4874
NDC1	-28	-272	-4667	6480
NUP107	2943	1017	-4115	6299
NUP133	2030	1473	-2474	935
NUP153	1372	7264	-1870	4343
NUP155	1163	5083	-3460	3043
NUP160	1232	5781	-4066	1293
NUP188	-2474	591	-3287	2922
NUP205	1308	370	-3162	1670
NUP210	-4099	775	-1841	690
NUP214	779	7322	3866	4368
NUP35	3287	7567	-4566	-557
NUP37	1488	500	-594	3398
NUP43	3972	139	-3557	6344
NUP50	2599	5772	-517	6704
NUP54	4432	6517	-2306	831
NUP62	-1277	2703	156	4608
NUP85	2428	5395	-713	4517
NUP88	1692	6430	-4454	7082
NUP93	1140	7850	-1307	2006
NUP98	808	1649	64	-747
PARP1	-2044	374	-4291	3582
POLR2A	-2661	-175	2387	4046
POLR2B	2791	1490	-2187	5561
POLR2C	-1223	4488	-1052	6354
POLR2D	1826	1345	-3754	-614
POLR2E	-4070	2983	1998	3712
POLR2F	-4130	6520	2177	509
POLR2G	-3529	8023	2161	1604
POLR2H	-1987	7555	-1495	6297
POLR2I	-4150	6339	-662	5655
POLR2K	3699	2452	-1615	3853
POM121	-4007	5147	-934	4680
POM121C	-4243	5643	-2686	2061
RAE1	2280	705	1931	2634
RANBP2	2136	4418	-1280	5164
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
SEC13	-1298	7330	2552	6209
SEH1L	3665	6621	-4109	3577
TPR	1846	5115	-1721	4615
UBA52	-3208	4386	-596	-69

---

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

metric	value
setSize	86
pMANOVA	1.31e-24
p.adjustMANOVA	7.22e-23
s.dist	0.689
s.t0_crp_RNA	-0.407
s.t0_crp_meth	-0.0542
s.pod_crp_RNA	-0.511
s.pod_crp_meth	0.215
p.t0_crp_RNA	7.72e-11
p.t0_crp_meth	0.387
p.pod_crp_RNA	2.86e-16
p.pod_crp_meth	0.000578

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938
RPS23	-3858	-3376
RPL38	-2941	-4417

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
CASC3	-2211	3328	2647	5105
DCP1A	2646	4253	-3323	5068
EIF4A3	-2476	5309	-384	4597
EIF4G1	-3029	3207	3785	5764
ETF1	3017	7097	1676	151
FAU	-4223	5971	-437	6875
GSPT1	2757	4351	-2932	-1153
NCBP1	4110	6523	-472	5857
NCBP2	4266	3714	-3787	4776
PABPC1	1721	3723	-1442	3011
PNRC2	4481	3773	-2191	5676
PPP2CA	2133	7688	1877	2598
PPP2R2A	4508	542	-554	-752
RNPS1	-2473	2186	-3151	537
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
SMG1	55	8307	-687	4788
SMG5	-2955	-215	-767	5172
SMG6	-2359	-678	-1874	6205
SMG7	1612	3107	3551	2361
SMG8	2347	7988	255	1691
UBA52	-3208	4386	-596	-69
UPF1	-2902	707	2612	5956
UPF2	3948	4005	-99	3840
UPF3A	-1847	6389	-3579	6961

---

---

Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)

metric	value
setSize	86
pMANOVA	1.31e-24
p.adjustMANOVA	7.22e-23
s.dist	0.689
s.t0_crp_RNA	-0.407
s.t0_crp_meth	-0.0542
s.pod_crp_RNA	-0.511
s.pod_crp_meth	0.215
p.t0_crp_RNA	7.72e-11
p.t0_crp_meth	0.387
p.pod_crp_RNA	2.86e-16
p.pod_crp_meth	0.000578

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938
RPS23	-3858	-3376
RPL38	-2941	-4417

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
CASC3	-2211	3328	2647	5105
DCP1A	2646	4253	-3323	5068
EIF4A3	-2476	5309	-384	4597
EIF4G1	-3029	3207	3785	5764
ETF1	3017	7097	1676	151
FAU	-4223	5971	-437	6875
GSPT1	2757	4351	-2932	-1153
NCBP1	4110	6523	-472	5857
NCBP2	4266	3714	-3787	4776
PABPC1	1721	3723	-1442	3011
PNRC2	4481	3773	-2191	5676
PPP2CA	2133	7688	1877	2598
PPP2R2A	4508	542	-554	-752
RNPS1	-2473	2186	-3151	537
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
SMG1	55	8307	-687	4788
SMG5	-2955	-215	-767	5172
SMG6	-2359	-678	-1874	6205
SMG7	1612	3107	3551	2361
SMG8	2347	7988	255	1691
UBA52	-3208	4386	-596	-69
UPF1	-2902	707	2612	5956
UPF2	3948	4005	-99	3840
UPF3A	-1847	6389	-3579	6961

---

---

Immune System

Immune System

metric	value
setSize	1142
pMANOVA	3e-22
p.adjustMANOVA	1.58e-20
s.dist	0.184
s.t0_crp_RNA	0.0358
s.t0_crp_meth	-0.0112
s.pod_crp_RNA	0.176
s.pod_crp_meth	0.0349
p.t0_crp_RNA	0.0495
p.t0_crp_meth	0.538
p.pod_crp_RNA	3.52e-22
p.pod_crp_meth	0.0555

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
WSB1	4190	4440
C3AR1	4547	4000
MX2	4101	4270
IDH1	4526	3628
LMNB1	4311	3711
TLR2	4156	3806
CD58	3835	4062
DCTN6	3502	4349
RAC1	4225	3574
SP100	3388	4417
SLA	3680	4046
UBA3	3656	4072
KLHL2	4184	3485
LGALS9	4298	3366
TANK	3220	4486
ADAM17	4464	3217
DNAJC13	3651	3873
PAK1	4129	3393
OASL	3095	4406
IFNGR1	3984	3407

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
A1BG	-4720	7280	525	567
AAAS	-638	2718	243	1467
AAMP	-4607	1163	-1372	7118
ABCE1	3662	2890	-4608	6004
ABI1	4121	520	2868	3253
ABI2	570	1453	-3567	-206
ABL1	-3241	5957	1585	2469
ABL2	-280	4972	-684	5307
ACAA1	-1087	6265	4528	5788
ACLY	-1395	2347	3652	2976
ACTB	-373	4248	4005	5446
ACTG1	-3456	6407	3191	1603
ACTR10	2603	5113	1646	4867
ACTR1A	-1288	879	3846	1932
ACTR1B	-3875	3798	-2148	2629
ACTR2	3144	4932	2747	3844
ACTR3	2753	4481	2482	5950
ADAM10	2914	3590	3423	2760
ADAM17	3217	4696	4464	4154
ADAM8	-2204	7454	2256	5096
ADAR	2970	5925	1386	3087
ADGRE5	-2627	2052	3671	-1468
AGA	-2883	-401	-2619	2162
AGL	2065	2754	-959	1016
AGPAT2	-3761	-328	4455	-1386
AHCYL1	1297	6888	1605	2692
AIM2	2677	-558	720	-1275
AIP	-4146	1494	-31	6682
AKT1	-4471	4213	2297	1109
AKT2	-4622	3462	2041	5430
ALAD	-4161	371	4014	1057
ALDOA	-1859	643	4238	5366
ALDOC	-367	7284	-2691	65
ALOX5	330	6127	4345	5385
AMPD3	-1687	4553	3545	3216
ANAPC1	-1080	3338	-4436	2990
ANAPC10	2049	-304	48	-1324
ANAPC11	-4132	7036	1733	3188
ANAPC13	2519	2410	-1936	493
ANAPC2	-4276	1380	-883	2865
ANAPC4	4253	1488	341	-687
ANAPC5	1471	3129	-1620	5212
ANAPC7	4117	862	1103	1873
ANO6	-849	7646	-21	1102
AP1B1	-3672	7580	4242	5781
AP1G1	1620	6342	1504	2214
AP1M1	-4217	2143	3873	1777
AP1S3	938	5055	686	1942
AP2A1	-2927	1888	4575	-316
AP2M1	-4018	5714	2737	3723
AP2S1	-1597	3981	3589	6037
APAF1	1473	7512	2266	-809
APEH	-3872	429	1730	832
APP	-1029	7569	1303	6621
APRT	-4283	7658	-2811	2643
AREL1	-694	2081	3585	5152
ARF1	-3573	8373	3973	-1819
ARHGAP9	-2519	389	4113	6255
ARIH1	2666	5821	-1008	3751
ARIH2	-3057	1230	-3373	3734
ARL8A	-3571	135	3462	-1057
ARMC8	3399	4263	67	2641
ARPC1B	-3236	2831	4244	1709
ARPC2	1775	5683	3457	2292
ARPC3	2785	4820	3580	3208
ARPC5	2109	2335	3836	2611
ARSA	1972	-580	3635	523
ARSB	1416	6851	3997	-1526
ASAH1	2991	3487	4461	2174
ASB1	-3201	-377	3505	6029
ASB13	401	6720	-773	1754
ASB2	-2074	-447	-2489	6211
ASB6	-2439	2646	1941	-1068
ASB7	-758	3722	-1329	6527
ASB8	695	929	989	5452
ATAD3B	-3224	5569	-2736	4810
ATF1	4365	685	1579	2989
ATG12	4083	4620	-2436	6821
ATG5	4418	1135	-2277	-680
ATG7	2082	1256	2282	3847
ATOX1	-2402	7999	2468	390
ATP11A	-1708	5464	4170	132
ATP11B	1100	-213	1786	-241
ATP6V0A1	-73	5522	4481	-1569
ATP6V0A2	1039	5229	-2100	6651
ATP6V0B	-2906	4920	4040	5502
ATP6V0C	-819	2497	4204	2933
ATP6V0D1	-717	5801	4411	6934
ATP6V0E1	-98	5534	3098	1836
ATP6V0E2	688	-8	-3868	-1325
ATP6V1A	2260	3916	3165	-1495
ATP6V1B2	1335	2965	3679	-1553
ATP6V1C1	3195	3435	3307	6757
ATP6V1D	3158	446	3682	1096
ATP6V1E1	3127	6210	2844	4775
ATP6V1F	-2969	2955	1967	-699
ATP6V1G2	-783	7744	-3696	3740
ATP6V1H	2094	5695	1932	2559
ATP8A1	-1321	-197	-4498	-913
ATP8B4	80	-467	612	-1099
B2M	3496	3645	-3314	-9
B4GALT1	-2606	7929	1953	7041
BAIAP2	-3214	6287	-510	2757
BATF	-1671	2924	1438	6677
BCL10	3129	6246	1603	2575
BCL2	891	55	-3102	7020
BCL2L1	168	5903	-129	5968
BCL2L11	72	5304	2972	5662
BCL6	-1059	973	4510	3669
BIN2	-3373	3302	4006	5389
BIRC2	4449	4494	-741	6624
BIRC3	3504	588	-4618	4816
BIRC5	2315	6240	-142	1965
BLMH	738	1330	-1570	-120
BRI3	-1874	3754	4413	-1176
BRK1	-4091	8027	-825	3071
BRWD1	817	-90	-2860	-349
BST2	1250	-703	383	-1933
BTBD1	3809	4362	-1966	120
BTBD6	-4485	1663	-3446	3006
BTN2A1	3255	2288	1451	1617
BTN2A2	776	6643	-2397	108
BTN3A1	2243	3036	-2606	1278
BTN3A2	-1663	5782	-4090	3317
BTN3A3	416	3557	-3440	6402
BTRC	-2069	66	-3130	-923
C3AR1	4000	1722	4547	-1594
C6orf120	-845	7883	319	3829
C8G	-1876	4665	114	-1364
CAB39	2427	-206	2233	7106
CALM1	1287	3980	-2201	4501
CALR	1148	3542	1904	5712
CAMK2D	-1499	3793	-4469	-529
CAMK2G	943	31	471	6716
CAND1	2021	1725	-3244	2163
CANX	1285	7328	-533	3479
CAP1	497	5559	3138	2034
CAPN1	-3906	5471	3918	1819
CAPZA1	4166	7801	2992	999
CAPZA2	3798	3735	2976	4666
CAPZB	-747	3052	3210	-308
CARD11	-3851	5791	-4243	6542
CARD9	-3315	-774	3670	-1761
CASP1	4199	-379	2331	7029
CASP10	2029	1610	1690	-1805
CASP3	4360	3118	1576	5689
CASP4	3211	507	2271	-96
CASP8	2071	5784	-2229	5447
CASP9	110	698	4367	3202
CAT	282	-220	3549	-1204
CBL	-1090	7589	3285	1012
CBLB	-2176	3114	-4258	343
CCND1	-2434	3555	-1529	1006
CCNF	-988	3827	-1935	392
CCR1	2329	4664	3112	-1919
CCT2	1454	3443	-4591	194
CCT8	2610	2003	-111	2904
CD247	-4182	3160	-4496	6034
CD274	2935	-9	-3362	-305
CD300A	2225	-861	4103	-1998
CD3D	799	-531	-4088	7271
CD3E	2250	-641	-4427	7190
CD4	-528	5984	-2076	909
CD44	498	4392	3154	4897
CD46	4402	5368	2807	5538
CD47	2166	2442	-3816	6601
CD53	2247	-462	3926	6482
CD55	1738	3285	4145	1455
CD58	4062	5810	3835	-611
CD59	-1703	4468	-1328	-1682
CD63	-2910	7177	4520	5433
CD74	-1224	-79	-2623	-648
CD79B	-2270	5017	-3176	-1165
CD81	-2406	2412	-2059	3296
CD96	-1754	1424	-4660	6876
CDC16	1700	7029	-672	3340
CDC20	-670	5825	-791	2639
CDC23	3736	4379	-3706	1597
CDC34	-4179	6224	2873	-408
CDC42	3320	7040	2741	856
CDK13	-2241	5468	9	5777
CDKN1A	1249	7552	1225	2427
CDKN1B	-532	1651	-3401	3367
CEACAM1	-237	822	1684	5458
CEBPD	-2296	1317	3893	-907
CENPE	4361	2608	751	-74
CEP290	4268	7316	-2743	7000
CFL1	-3249	4059	3672	1646
CHUK	2695	2702	2681	1111
CISH	3901	4706	292	4927
CKAP4	-813	8287	3854	-987
CLEC2B	2572	2977	-2710	2668
CLTA	185	1469	2876	-546
CLTC	461	2670	3511	7256
CMTM6	3583	4072	2869	1926
CNN2	-1565	2034	1954	-418
CNPY3	-2430	3188	3017	1242
COMMD3	3610	606	665	-1960
COMMD9	1680	85	3383	2239
COPB1	4354	2889	2313	2637
COTL1	671	2421	4276	6759
CPNE1	-1872	4807	-478	5131
CPNE3	1598	2499	-94	-1441
CPPED1	340	5747	4044	-641
CRCP	998	6155	1033	4707
CREB1	2387	5046	-1542	1422
CREBBP	-4011	6807	2122	892
CREG1	-2492	1563	2917	-1059
CRK	3068	5936	3523	6596
CRKL	-1398	7466	-102	5166
CSF1	916	1541	-2144	356
CSK	-2994	1998	3950	4889
CSNK2B	63	7476	2450	4742
CSTB	469	6900	4229	2893
CTF1	-2377	7037	825	543
CTLA4	-1839	-754	-2871	7088
CTNNB1	2009	6708	3025	5069
CTSA	-2481	2086	4047	2720
CTSB	83	7057	4475	-965
CTSC	2238	2310	3599	1311
CTSD	-3067	8404	4479	6620
CTSL	873	8363	4377	3028
CTSO	2777	7410	-3278	5110
CTSS	2274	-506	2686	-1544
CTSV	-308	7141	-258	5169
CTSZ	-1191	-74	4162	-1978
CUL1	4355	1572	-4161	-1190
CUL2	4307	5990	178	2207
CUL3	1497	3752	642	-873
CUL5	4190	5397	-1036	344
CUL7	-2371	2156	2841	6186
CXCL2	-4220	7587	1113	-1988
CYB5R3	-4015	4980	3732	3239
CYBA	-2911	5359	4087	2019
CYFIP1	644	8297	4331	256
CYFIP2	-1585	4227	-2032	6157
CYLD	1079	5350	-4487	5704
CYSTM1	594	7301	3572	-1740
DAPP1	3557	7887	182	6836
DBNL	-4518	2964	3614	-406
DCTN2	-3591	-463	4022	-727
DCTN3	-2237	4070	2936	2751
DCTN4	3328	3748	3561	4416
DCTN5	-4299	7627	-377	6058
DCTN6	4349	6414	3502	6880
DDX41	-4055	5715	1011	4425
DDX58	4465	2907	-3747	185
DEGS1	-1317	4783	-164	3203
DERA	3518	7409	3669	3602
DET1	2062	4399	-2294	122
DGAT1	-3399	6428	2057	-576
DHX36	3868	1789	-1657	6438
DHX58	3998	1444	-1341	-30
DHX9	243	6405	-2418	5545
DIAPH1	-659	5118	910	2371
DNAJC13	3873	207	3651	408
DNAJC3	2858	8289	3092	6470
DNAJC5	-2985	3110	3776	-1396
DNM1	2874	2154	2211	1607
DNM2	-4239	6583	3699	3063
DPP7	-4644	7245	-1735	6584
DSN1	2407	2698	-1398	-996
DTX4	-4129	5372	3400	5143
DUSP3	-328	6561	3398	2260
DUSP4	1176	3581	-1089	2494
DUSP6	-534	7727	-1313	-1941
DUSP7	-2585	6442	-1315	722
DYNC1H1	-2872	1165	-441	4433
DYNC1I2	3141	258	2171	693
DYNC1LI1	3353	6061	2935	3242
DYNC1LI2	1369	3124	3014	-185
DYNLL1	-405	5371	1250	5150
DYNLL2	-3503	3295	-3679	-924
DYNLT1	2953	4660	2802	5599
DZIP3	391	378	-4227	-958
ECSIT	-1973	6302	1201	1450
EDARADD	1265	7621	-3682	6839
EEA1	3244	1440	-457	5334
EEF1A1	-3462	2007	-4432	2941
EEF2	-4680	1309	-3170	4195
EGR1	-4716	7086	-3070	1893
EIF2AK2	4506	187	169	683
EIF4A1	568	5332	2238	881
EIF4A2	3750	5307	-4415	3601
EIF4A3	-2476	5309	-384	4597
EIF4E	4474	5594	818	6719
EIF4E2	-432	2798	2567	5874
EIF4E3	4105	-720	3038	-661
EIF4G1	-3029	3207	3785	5764
EIF4G2	1621	6211	552	6371
EIF4G3	-331	893	4056	1034
ELMO1	-2007	4440	-587	939
ELMO2	2276	3622	3753	6108
ENPP4	1515	1338	-2234	3170
EP300	-1082	3351	3310	4900
ERAP1	-2570	2680	-1115	1806
ERAP2	3962	4	2368	-756
ERP44	3533	127	1159	920
EVL	-2581	3789	-3990	7073
FABP5	1248	3657	2416	2233
FADD	-32	2272	2169	-329
FAF2	230	7630	1614	2842
FBXL12	-3258	945	196	4059
FBXL14	-4389	1537	-2683	6754
FBXL15	-2923	3574	1356	970
FBXL16	-4026	7450	-4623	6376
FBXL18	-948	5478	2834	853
FBXL19	-3282	7568	4517	-220
FBXL20	3871	7030	2442	1213
FBXL22	-2807	7779	-2664	5650
FBXL3	2952	7436	-2105	2065
FBXL4	3807	3684	1020	1511
FBXL5	3400	6904	3439	6718
FBXL8	-3113	7487	-426	5372
FBXO11	4419	1968	1922	7062
FBXO15	3435	5306	1026	2131
FBXO21	1051	4757	-3028	6288
FBXO22	4322	1300	461	-930
FBXO30	3411	6130	-576	1907
FBXO31	-2815	5960	-4612	4755
FBXO32	-2830	6776	-4547	6486
FBXO4	1020	4804	-4282	106
FBXO6	235	75	3428	92
FBXO7	1953	2193	-93	2923
FBXO9	2621	5830	4508	3195
FBXW11	-1449	8406	480	-1506
FBXW2	1823	709	3786	2654
FBXW4	-95	1675	-3195	136
FBXW5	-4477	-593	1507	-1870
FBXW7	1395	6293	-812	6665
FBXW8	-2672	2431	-2647	4558
FGR	-1601	6431	4539	-1074
FKBP1A	2460	6115	3110	1814
FLNB	-2802	3880	2494	675
FLT3LG	-2752	4449	-4476	6675
FOS	-4562	4067	-1568	5645
FOXO1	-3602	816	-4632	3034
FOXO3	-3051	7309	2545	5022
FTH1	-378	3718	2380	3117
FTL	609	3955	3972	-1424
FUCA1	-689	2325	2425	1656
FUCA2	1128	614	2428	-1234
FYN	-2118	2799	-2956	2793
FZR1	-3205	7403	689	2326
GAA	-1924	1082	3079	2768
GAB2	-2692	347	3912	2390
GALNS	-2319	6550	3709	3670
GAN	305	4487	362	3655
GATA3	-395	8146	-4535	6272
GBP3	2699	7680	-3061	89
GCA	3226	2697	4151	5559
GDI2	3001	7874	2004	3343
GGH	2821	6701	1044	3861
GHDC	-3703	2847	1243	-571
GLB1	890	7186	4196	1828
GLIPR1	3846	390	2195	5591
GLMN	4382	7415	-3770	-22
GM2A	2719	6404	4388	6361
GMFG	254	6320	3611	6367
GNS	1404	5454	4533	4428
GOLGA7	1327	3410	-2030	3104
GPI	-2280	6574	1799	5672
GRAP2	-2746	6230	-2761	3631
GRB10	561	190	4532	3328
GRB2	29	5972	4230	6239
GRN	-475	3078	4312	4937
GSDMD	-2417	4172	1671	-91
GSTO1	347	7221	3900	3633
GSTP1	-976	6809	683	-1350
GUSB	-2488	4868	4470	2338
GYG1	-319	6447	3938	-231
GZMM	-3093	-219	-3628	7249
HACE1	1927	5481	-841	-395
HCST	-3713	2904	521	1324
HEBP2	-1887	5561	2156	552
HECTD1	-719	4129	185	5899
HECTD3	-797	7407	3479	463
HERC1	480	3575	-1171	1913
HERC3	772	3454	1230	3912
HERC4	4524	-156	1233	232
HERC5	4477	1222	-3630	-1037
HEXB	1519	7559	2594	2906
HGSNAT	-63	352	-1489	3342
HIF1A	1346	4099	2872	2448
HLA-A	-4080	2266	-2368	-1093
HLA-B	-821	510	896	-730
HLA-C	51	6767	1218	4448
HLA-DMA	869	1536	-1299	-1926
HLA-E	-950	3730	-1002	5634
HLA-F	-3752	-24	-904	2974
HLA-H	-4350	7821	-546	4988
HMGB1	1943	2521	-3489	3222
HMOX2	-3769	699	-4339	6411
HNRNPA2B1	1271	2586	2367	2721
HNRNPF	-3188	3524	-532	5855
HRAS	-3453	1483	-1282	-823
HSP90AA1	3100	4857	-2176	6208
HSP90AB1	1227	824	-4305	-1224
HSP90B1	4301	7702	-1893	2127
HSPA1A	-3490	1106	2517	-920
HSPA1B	1576	750	1718	655
HSPA9	-243	5862	-4493	6549
HVCN1	-951	1427	1485	-385
ICAM1	-1757	6181	1880	2036
ICAM2	-608	980	-4564	4818
ICAM3	-4729	900	2016	6838
ICAM5	-1816	7084	4495	4185
ICOSLG	-1952	8090	-2193	4496
IDH1	3628	3280	4526	3454
IFI30	2632	3541	4450	-1602
IFI35	3572	205	3006	1292
IFI6	3862	913	967	5535
IFIH1	4466	4707	-2544	2681
IFIT1	4407	25	-3881	312
IFIT2	4291	-226	-3900	1477
IFIT3	4438	7094	-2788	6159
IFIT5	4463	7233	-4089	3745
IFITM1	1081	813	-1754	6983
IFNAR1	2671	6039	3008	1219
IFNAR2	-1339	1943	3116	1115
IFNGR1	3407	4319	3984	4124
IFNGR2	2871	6499	4530	4230
IGF2R	-4041	-23	3850	-1657
IKBKB	-1861	958	1970	-912
IKBKE	-39	5956	3231	6703
IL10RA	-2658	3506	605	5516
IL10RB	2492	1088	4296	-1075
IL12A	1447	2118	-2780	-1315
IL12RB1	-2291	-670	-1696	6630
IL12RB2	-4567	1065	-4043	-1859
IL15	1769	6831	1135	3611
IL15RA	3307	3533	2179	-1086
IL16	-3248	4110	-2267	5457
IL17C	-2577	-487	3055	-1128
IL17RA	388	5913	4322	130
IL17RC	-3722	7073	-539	1939
IL18BP	1389	-326	316	-1638
IL18R1	-2304	7423	850	6742
IL19	2005	-683	2850	7263
IL1RAP	2063	39	2084	-1120
IL21R	-2031	2004	-3090	2722
IL23A	1948	-668	-4551	7076
IL27RA	295	4390	2711	6657
IL2RA	1014	432	-3039	6866
IL2RB	-4721	5850	-4587	7234
IL32	616	212	-4349	7265
IL4R	-494	-410	3746	1274
IL6R	-583	6529	1258	5065
IL6ST	3221	3452	-1202	1708
ILF2	2531	-350	-1689	2770
IMPDH1	-1286	6	4428	2600
IMPDH2	-3789	5334	-4679	250
INPP5D	-3830	1160	2964	55
INPPL1	-2826	7266	4370	588
IP6K2	1553	7287	744	799
IQGAP1	-6	372	3381	587
IQGAP2	2140	2768	3344	3888
IRAK2	-3547	7809	-2980	4685
IRAK3	1420	2776	4357	666
IRF1	302	5434	-2536	5830
IRF2	3372	5303	2864	2365
IRF3	-2649	2791	-1301	4240
IRF4	2179	4585	-3146	5939
IRF5	-223	8174	2710	-1649
IRF7	2494	6595	3230	3556
IRF9	4132	5108	884	4774
IRS1	-4535	4409	-2997	4307
IRS2	-4076	5285	3498	6150
ISG15	3651	-537	-3046	6539
ISG20	-143	-116	-2935	7058
IST1	2520	1926	2863	1014
ITCH	421	6841	732	4853
ITGA4	1894	4646	-3651	-394
ITGAL	-1994	4404	1129	7036
ITGAV	2010	3274	3023	-370
ITGB2	-4211	745	4253	6424
ITGB7	2421	362	-3588	-1689
ITK	-839	-349	-4350	-1699
ITPR1	-1901	6612	-1565	1789
ITPR2	1162	4456	2298	-44
ITPR3	-748	2875	-2503	2189
JAK1	-3630	6963	-3720	-283
JAK2	4309	6228	1486	6487
JUN	-3724	2763	-598	1283
JUNB	-4339	4464	541	5017
KBTBD6	541	5636	-1355	80
KBTBD7	1063	6403	893	-381
KBTBD8	1753	665	-760	834
KCMF1	1322	-488	1586	3310
KCNAB2	-4643	5909	2760	-600
KCTD6	2713	7603	2328	-621
KCTD7	-1407	7819	-3875	1682
KEAP1	-3069	5029	2242	1379
KIF11	2296	7352	-1688	1895
KIF15	1694	6303	-1340	6307
KIF18A	2515	2110	32	3290
KIF20A	627	-149	-591	1403
KIF22	-1338	3577	-4145	6181
KIF23	1258	2564	1959	805
KIF2A	-2414	107	-3921	4006
KIF2C	3056	5593	433	-12
KIF3A	1773	3240	-4199	6172
KIF3B	765	1867	1704	2018
KIF3C	-3143	2102	1672	-1428
KIF5B	3638	7491	2378	4669
KIFAP3	3661	5881	-2260	-68
KLC1	-2743	7465	2962	4385
KLC2	-1865	5384	-1364	1505
KLC4	-2811	2807	-494	4366
KLHL11	-3410	7014	-1379	5348
KLHL2	3485	5667	4184	6409
KLHL20	1080	2462	-2537	1429
KLHL21	-4647	2533	-395	5915
KLHL22	-4131	2637	-3639	1129
KLHL25	-4483	2495	-4514	4488
KLHL5	718	2938	-2940	3248
KPNA1	2982	6152	-1803	4422
KPNA2	2320	838	-1587	4420
KPNA3	3326	1397	-1791	4399
KPNA4	3677	8123	-297	4999
KPNA5	3718	1682	-3426	1847
KPNB1	2659	5901	-47	1140
KRAS	4442	4004	1217	3139
LAIR1	-901	6730	4482	3425
LAMP1	-4014	7954	3219	2553
LAMTOR1	-4534	-643	3758	-1587
LAMTOR2	-3989	-286	3497	-1340
LAMTOR3	3368	6744	792	957
LAT2	-1732	6599	4173	-1714
LCK	-1825	2493	-4488	7243
LCP1	1687	4158	3798	4311
LCP2	2815	-273	200	-428
LGALS9	3366	3238	4298	-1460
LGMN	-2484	6373	-3917	2706
LIMK1	-3358	-627	3471	-1748
LMNB1	3711	4088	4311	1051
LMO7	-3850	7894	-4172	7259
LNPEP	1126	2921	-1545	2406
LONRF1	905	4500	3456	6151
LPCAT1	-2710	-419	1992	1418
LRR1	819	8304	-2604	3790
LRRC41	-454	1095	4215	2878
LRRFIP1	3522	4814	3045	5296
LRSAM1	1862	7458	3833	5942
LTA	2971	-622	-4104	7253
LTA4H	2233	5699	4301	798
LTB	-2128	4959	-4443	5584
LTN1	2994	-772	-1685	7195
MALT1	633	7648	-4558	2545
MAN2B1	-2647	7254	2518	6387
MANBA	3782	4762	2996	6844
MAP2K1	-1421	-148	3921	1533
MAP2K3	-2498	38	3714	2411
MAP2K4	1784	3155	1767	4763
MAP2K6	3151	2164	3939	4791
MAP2K7	-4193	2092	431	1764
MAP3K1	1458	3815	1771	2247
MAP3K14	-2001	1381	-3221	4220
MAP3K3	-3332	2306	4125	3121
MAP3K7	2692	3839	1057	-147
MAP3K8	826	6359	4551	3266
MAPK1	-745	2758	4197	6097
MAPK14	1563	2227	4024	2465
MAPK3	-4620	-475	3649	1978
MAPK7	-2209	3007	3966	-244
MAPK8	-1037	6156	-3737	4553
MAPK9	-260	1152	-2605	157
MAPKAP1	1208	5508	898	5906
MAPKAPK2	-3939	1416	2421	3265
MAPKAPK3	-1142	58	4580	2896
MAVS	-3312	5447	2245	4280
MEF2A	2271	7441	3276	3013
MEX3C	-3854	4091	-4532	6167
MGRN1	-3170	2839	3860	-1403
MICA	-120	6694	-319	3105
MICB	-79	3279	3613	3131
MIF	-3715	2437	-3047	3355
MKRN1	84	7896	951	2197
MLEC	-1358	5314	-1498	2183
MLST8	-2723	3408	89	2258
MMP25	-966	6396	4100	6852
MNDA	3361	1442	3506	-1994
MPO	-3878	344	-3645	-1967
MRC2	-1341	7047	-1053	-577
MT2A	493	3765	33	1186
MTAP	2432	8029	-2882	2271
MTOR	-3867	1233	454	3900
MUC1	-1022	6782	2987	6713
MUC12	3257	3997	-166	4640
MUC5B	758	-829	2510	-1743
MVP	-3502	7998	3433	6953
MX1	4155	1144	-2305	-1015
MX2	4270	-240	4101	1798
MYD88	1536	2750	4540	1945
MYH9	-3635	3380	2352	6144
MYLIP	-1998	4478	-3408	2479
MYO9B	-2080	3138	4362	6775
NAPRT	214	-73	4098	-1869
NBEAL2	-2403	5606	4127	1726
NCF4	-2178	-141	4210	-1939
NCK1	3861	1096	-4123	1018
NCKAP1L	650	1928	4458	-320
NCKIPSD	-3678	7993	-3134	667
NCSTN	1556	-453	4578	1224
NDC1	-28	-272	-4667	6480
NDUFC2	-2586	5313	2549	2881
NEDD4	2622	6200	3146	-1104
NEDD4L	-2331	220	3504	-1079
NEU1	660	3057	4459	1899
NF2	54	981	522	1410
NFATC1	-3266	6729	-1906	6945
NFATC2	-2966	5180	-4600	7156
NFATC3	514	4876	-3772	1668
NFKB2	-128	2515	499	5250
NFKBIA	-1959	3670	1551	6812
NFKBIB	-4043	4651	2779	5572
NFKBIE	2782	952	-992	4746
NHLRC3	3852	5873	2633	4505
NIT2	2452	1153	-3459	-141
NKIRAS1	-1254	4201	-3568	348
NKIRAS2	-2892	2008	4410	-1130
NLRC5	-108	-233	1147	1905
NLRP1	-1719	7053	-761	3033
NLRP3	-16	6382	3342	-847
NLRX1	-4356	-359	4251	768
NME2	1390	1732	-173	-880
NOD1	702	2037	268	-321
NOD2	948	2355	4498	6608
NOS3	929	4038	-3056	4048
NPC2	2405	6347	2830	2198
NUP107	2943	1017	-4115	6299
NUP133	2030	1473	-2474	935
NUP153	1372	7264	-1870	4343
NUP155	1163	5083	-3460	3043
NUP160	1232	5781	-4066	1293
NUP188	-2474	591	-3287	2922
NUP205	1308	370	-3162	1670
NUP210	-4099	775	-1841	690
NUP214	779	7322	3866	4368
NUP35	3287	7567	-4566	-557
NUP37	1488	500	-594	3398
NUP43	3972	139	-3557	6344
NUP50	2599	5772	-517	6704
NUP54	4432	6517	-2306	831
NUP62	-1277	2703	156	4608
NUP85	2428	5395	-713	4517
NUP88	1692	6430	-4454	7082
NUP93	1140	7850	-1307	2006
NUP98	808	1649	64	-747
OAS1	4069	-193	1675	-1505
OAS2	4422	3120	-3241	6616
OAS3	3858	5403	-3256	616
OASL	4406	6399	3095	5927
ORAI1	-3662	2145	-3206	2153
ORAI2	-2396	-391	2252	-132
ORMDL3	-3219	2570	-3756	3085
OSCAR	1666	2313	4583	7120
OSM	-4108	1297	161	1355
OSTF1	1009	7525	2469	6468
P2RX1	2272	2764	4586	-1947
P4HB	-3022	6808	3555	5716
PA2G4	1938	2826	-2412	5242
PAFAH1B2	2330	4486	909	2435
PAG1	-2026	5032	128	6277
PAK1	3393	4953	4129	2452
PAK2	3060	2498	2198	283
PANX1	894	1287	2763	3960
PCBP2	-2726	1016	-881	3201
PDAP1	-4405	8096	3697	2952
PDCD4	3138	54	-4445	4219
PDE12	3461	-499	-1337	6081
PDIA3	1626	1035	1128	4845
PDPK1	-3330	144	2187	346
PDXK	-1102	4954	2867	1492
PELI1	829	1534	725	1867
PELI2	-80	8419	1276	7033
PELI3	-4660	3884	4288	-1121
PFKL	-4475	23	464	-1730
PGAM1	-1229	1586	4418	1307
PGM1	-3622	4559	1829	776
PGM2	1298	3342	3609	5133
PIAS1	4489	7666	1762	2845
PIK3AP1	131	4960	4137	1373
PIK3CA	2884	3277	-475	1470
PIK3CD	-4035	151	2426	6107
PIK3R1	-2132	5137	-4392	6991
PIK3R2	-2279	5345	2344	3831
PIK3R3	2060	3520	1094	3645
PIK3R4	2189	2075	-1855	2170
PILRB	-2504	7827	-1429	2683
PIM1	-708	2982	1290	1390
PIN1	-4611	3766	76	4014
PITPNA	512	1692	3198	3616
PJA2	1859	7717	2299	2112
PKM	-1111	1474	4062	3231
PLA2G6	-4368	2559	-2235	826
PLAC8	-1486	3803	4406	1235
PLAU	-1912	5281	914	-1527
PLAUR	226	4310	4189	-861
PLCG1	-749	5789	-3949	958
PLCG2	-1458	6158	3982	2803
PLD1	2370	2188	4049	-902
PLD3	-2550	2237	2394	354
PLEKHO2	703	6284	4254	6697
PML	1705	1158	976	4574
PNP	823	2158	3217	3516
POLR1C	2228	2648	-3560	5328
POLR1D	804	3932	385	6780
POLR2E	-4070	2983	1998	3712
POLR2F	-4130	6520	2177	509
POLR2H	-1987	7555	-1495	6297
POLR2K	3699	2452	-1615	3853
POLR3A	386	3837	301	5225
POLR3C	3386	7974	466	3978
POLR3D	-2976	180	-3773	1967
POLR3E	-4047	6433	-3136	1113
POLR3F	3336	7901	-2866	-1022
POLR3G	587	7022	-3591	6659
POLR3GL	192	230	-854	204
POLR3H	-4544	6311	-4490	5544
POLR3K	926	708	710	891
POM121	-4007	5147	-934	4680
POM121C	-4243	5643	-2686	2061
POU2F1	3493	5425	2773	3909
PPIA	-239	5602	-1924	4554
PPIE	1995	6743	-2167	6025
PPM1B	3124	-194	1490	-144
PPP2CA	2133	7688	1877	2598
PPP2CB	3173	15	2037	2771
PPP2R1B	1368	607	-1191	6169
PPP2R5A	1917	1224	2809	-230
PPP2R5B	-1113	7049	4073	-286
PPP2R5C	1533	5894	-3487	7072
PPP2R5D	-1009	5720	986	3470
PPP2R5E	792	2414	-2786	1402
PPP3CA	-123	1244	-187	5978
PPP3CB	4151	5256	913	4044
PPP3R1	579	5005	124	2945
PRCP	2944	6346	2835	611
PRDX6	-1247	4144	-345	5477
PRKACA	-1378	3969	4529	890
PRKACB	559	7713	-4630	1712
PRKCB	-3677	4193	2655	4963
PRKCD	301	8167	4500	6358
PRKCE	-1194	7105	3475	-1183
PRKCQ	-1185	3922	-4577	4207
PRKCSH	-4486	5300	2163	4697
PRKDC	-1551	8114	-2256	6474
PRR5	-4233	4574	-4217	-347
PRTN3	-4653	8354	-2832	5619
PSAP	506	1283	3823	628
PSEN1	2104	1717	4209	4954
PSMA1	2917	5206	1363	4758
PSMA2	1509	4929	-836	5163
PSMA3	4416	1432	-1823	3586
PSMA5	3047	4175	-2828	3319
PSMA6	3897	6144	1661	6676
PSMA7	-246	5863	3266	6901
PSMB1	-371	2981	-803	5409
PSMB10	-3433	689	-161	6388
PSMB2	835	-501	1803	1518
PSMB3	23	780	3778	4305
PSMB5	-2694	183	3229	269
PSMB6	-3103	5638	3472	5817
PSMB7	-2378	1587	2955	4198
PSMB8	949	1746	2054	5155
PSMB9	-217	3058	-3454	4468
PSMC1	928	2242	2194	1413
PSMC3	-2624	4680	847	736
PSMC4	-1230	1188	537	3431
PSMC5	-1694	2039	-2600	5094
PSMC6	4108	118	1373	2356
PSMD1	2911	5546	2375	56
PSMD11	4009	2032	2637	3521
PSMD12	4511	5250	2167	3681
PSMD13	-998	7807	1482	561
PSMD14	3360	3896	85	6314
PSMD2	-3334	6719	2097	3610
PSMD3	-4637	3063	1629	5579
PSMD4	-1530	1685	3940	5313
PSMD6	1854	3171	3275	2336
PSMD7	3595	864	596	2079
PSMD8	-2435	7747	2069	4665
PSMD9	-3510	-186	3384	3375
PSME1	1353	7210	-2849	1614
PSME2	3304	7208	-1478	778
PSME3	802	6539	2470	5231
PSME4	3349	7885	-461	5908
PSMF1	-1946	2260	416	7179
PSTPIP1	-3181	2316	4195	680
PTEN	2106	3654	2736	4814
PTGES2	-4318	-433	-1375	-901
PTK2	-814	2487	-1377	-475
PTK2B	-3952	4106	4499	4528
PTPN1	-1209	-294	3707	699
PTPN11	-256	3762	1122	5061
PTPN12	608	-601	1634	-982
PTPN13	-4440	8337	-2577	6848
PTPN18	-1734	887	4371	3436
PTPN2	2787	3163	4008	181
PTPN22	3623	-461	2125	5980
PTPN23	-1373	3838	2730	5426
PTPN4	-398	1836	-4481	784
PTPN6	-1174	2534	4395	6540
PTPN7	1233	1319	-1494	2323
PTPN9	-858	2987	4448	6094
PTPRC	3660	1759	2823	-936
PTPRJ	-2062	6860	3552	7167
PTPRN2	-1502	1639	-965	6583
PYCARD	-1515	3142	4319	-1818
PYGB	-3390	-229	-1259	141
QPCT	1033	1841	3998	-1472
QSOX1	-2300	6788	4519	5725
RAB10	2203	1022	4224	3067
RAB14	3720	1861	1150	-378
RAB18	4478	1161	1696	2764
RAB24	1932	257	4083	-168
RAB27A	3269	7260	2952	222
RAB37	-1677	7528	-2789	409
RAB3A	-4569	3507	482	4347
RAB3D	604	5944	3885	1148
RAB4B	-2727	7770	3909	4687
RAB5B	-516	1208	1896	1957
RAB5C	-2850	2984	3898	797
RAB6A	3034	6426	2839	3323
RAB7A	837	-522	3489	-124
RAC1	3574	7484	4225	5539
RAC2	-3760	6815	1945	4576
RACGAP1	3851	3065	2101	4089
RAE1	2280	705	1931	2634
RAF1	537	4277	3739	6571
RALA	2197	1756	-3637	2302
RANBP2	2136	4418	-1280	5164
RAP1A	4512	2607	2624	6567
RAP1B	2749	6134	2033	5966
RAP2B	-283	6562	394	5291
RAPGEF1	-3506	6250	1511	6443
RASGRP1	500	3237	-4511	5886
RASGRP2	-3881	4893	-1986	-413
RASGRP3	2257	966	-2637	760
RBBP6	3635	3405	-1799	2861
RBCK1	20	93	3817	-510
RBSN	-2650	7872	-1916	6352
RBX1	1451	6206	1453	5881
RCHY1	2651	4138	-16	6484
REL	599	3	3083	1779
RELA	-4376	5729	-1050	4332
RELB	-1928	4179	2626	577
RHOA	2796	1879	3280	4033
RHOF	-3403	3511	-4235	6476
RHOG	-703	3967	4093	3664
RICTOR	2489	4606	-2585	2833
RILP	-778	5200	3062	4298
RIPK3	1097	1791	4431	6793
RNASEL	1776	3068	3937	3400
RNASET2	-1180	732	3304	7087
RNF111	2625	5548	609	6047
RNF114	2111	-231	1594	6
RNF115	2391	7670	-785	5803
RNF123	-4320	-659	3883	5284
RNF125	-499	4923	-4473	6174
RNF126	-3727	1447	-2733	5632
RNF135	1671	2669	4476	-1613
RNF138	3007	3835	-3918	7051
RNF14	2201	-570	288	-1370
RNF144B	896	7326	4315	-81
RNF19A	2951	4760	-2298	6512
RNF19B	-874	5050	2188	2765
RNF213	901	3688	-1362	7094
RNF216	-3207	1260	-3286	4490
RNF220	-4646	3784	-1572	215
RNF25	1312	7230	171	5176
RNF34	3724	5286	-1181	1414
RNF4	250	1925	-1905	4132
RNF41	-467	2353	4133	4401
RNF6	-1329	2767	-1001	366
RNF7	-414	1274	2999	5839
ROCK1	4037	2208	2623	2732
RORA	-1351	7045	-4542	6931
RPLP0	-4068	5078	-4060	4850
RPS27A	-3731	2481	-4078	2589
RPS6KA1	-2393	6272	4241	-1857
RPS6KA2	-3185	6436	-715	2117
RPS6KA5	4173	7351	-3252	1991
S100A11	1465	3952	4310	6087
S100P	-3641	627	3560	3303
S1PR1	-19	-331	-3578	6789
SAMHD1	3503	7333	3768	6189
SAR1B	4471	7978	1753	3060
SARM1	-3359	8141	-3432	4841
SCAMP1	2598	7802	-3481	2645
SDCBP	3311	7419	3605	3834
SEC13	-1298	7330	2552	6209
SEC23A	2416	6271	707	1833
SEC24A	2469	2022	2595	4761
SEC24B	3316	7026	1710	-13
SEC24C	-1756	902	2641	-336
SEC24D	2700	6653	3967	1527
SEC31A	2995	5193	779	2523
SEC61A1	-402	5868	1559	421
SEC61A2	3544	6636	-1344	301
SEC61B	-1073	453	1749	6422
SEC61G	4221	2858	-947	1928
SEH1L	3665	6621	-4109	3577
SERPINB1	990	-241	4236	-1477
SERPINB6	-3927	7977	3455	2823
SH2B1	-1908	4860	-1276	1436
SH2B3	-2452	3414	3520	3851
SHC1	47	7294	2954	3205
SIAH1	2118	5750	616	494
SIAH2	2202	1871	438	6695
SIGIRR	-3514	8336	-2448	6805
SIKE1	3833	950	-2073	1675
SIPA1	-4632	2967	2579	-1268
SKP1	3454	3180	-2543	2680
SKP2	4229	3426	-225	1707
SLA	4046	366	3680	6984
SLA2	-2415	6510	-4294	4870
SLAMF6	-774	2522	-4185	6834
SLC11A1	-326	1277	4588	4001
SLC15A4	-384	-645	3676	-1575
SLC27A2	3534	3271	-3276	-1409
SLC2A3	-2653	4133	3706	-1209
SLC44A2	-3555	1449	11	4322
SLCO4C1	838	1673	1214	-99
SMAD3	-571	5305	-2989	-363
SMARCA4	-3629	2881	2224	6790
SMURF1	-765	197	1222	6932
SMURF2	1161	4750	-3814	3523
SNAP23	2642	7973	1694	-471
SNAP29	-4308	6060	3209	3148
SNRPA1	1550	6067	-2069	1539
SOCS1	3263	5646	2492	4130
SOCS2	1601	6635	-1294	6477
SOCS3	-4725	693	4095	6490
SOCS5	-415	3620	-1558	466
SOD1	90	6446	-2571	1838
SOD2	177	6323	3199	6132
SOS1	3053	3267	-1345	-1984
SOS2	2591	87	3354	3699
SP100	4417	3022	3388	2285
SPSB1	-3536	6092	981	582
SPTAN1	-4171	369	-4508	-407
SQSTM1	-3391	1301	-1278	658
SRC	-1769	-92	-2399	-1474
SRP14	2388	5802	1918	5762
STAT1	3698	949	-4441	4969
STAT2	3596	3473	1612	5931
STAT3	1049	7062	3091	4994
STAT4	1560	3811	-4377	4202
STAT5A	-3150	-563	3416	-1543
STAT5B	-2600	7765	1731	1495
STAT6	-2092	3383	4260	3854
STBD1	785	6119	-200	-658
STIM1	-4039	-127	3292	7262
STK10	-3634	3470	2725	-688
STK11IP	-4178	4530	3990	2122
STOM	312	-756	1358	-1584
STUB1	-4241	3481	-957	2320
STX1A	-1885	1038	248	4173
STX3	371	5386	3443	2712
STX4	-1332	4490	3053	1609
STXBP2	-623	7943	4521	-155
SUGT1	3689	6377	-97	5004
SUMO1	3870	4413	1420	3368
SURF4	-2330	5219	1962	3679
SVIP	2044	4128	-3340	1104
SYK	927	3885	3853	431
TAB2	1280	-849	-1462	6399
TALDO1	-497	2943	4000	4421
TANK	4486	5680	3220	6237
TAP1	2220	3661	-2414	3742
TAP2	1723	1437	-465	3057
TAPBP	-2695	5738	1575	2910
TAX1BP1	4184	1932	1345	1037
TBC1D10C	-4516	3143	-3275	6910
TBK1	4522	6493	2094	599
TCIRG1	-2526	4545	4576	1353
TCP1	2342	2222	-2270	-448
TEC	1638	2871	4185	170
TGFB1	-3576	4335	-268	3769
THEM4	-569	8295	-4563	809
THOP1	-2156	2490	-1444	3555
TICAM1	-372	1210	3650	1060
TIFA	1152	8170	-1422	4847
TIRAP	-1492	3362	2573	1661
TLR1	2786	2626	3278	-1111
TLR2	3806	6774	4156	4128
TLR3	605	6769	-4494	2949
TLR5	1902	3910	4264	5699
TLR6	1146	-591	2855	-1199
TLR9	-3285	-405	-837	7201
TMBIM1	-3251	2134	3467	-47
TMC6	-3434	1580	-1994	6748
TMEM179B	-176	1544	388	5595
TMEM30A	3654	7686	1750	6658
TMEM63A	-691	1367	-3328	2620
TNF	3685	-672	-2015	-526
TNFAIP3	-2738	1870	-572	6103
TNFRSF12A	-3458	8175	2338	681
TNFRSF1A	-757	1590	4369	-1546
TNFRSF1B	-1307	1250	4281	6868
TNFRSF25	-3232	307	-4613	6987
TNFSF13	-1161	5409	4326	-1362
TNFSF13B	3729	1281	2715	-384
TNFSF14	751	2869	1178	7175
TNFSF9	-267	-538	2679	447
TNIP2	-2442	793	2575	287
TOLLIP	-3659	1231	2911	664
TOM1	-3899	5174	4227	4279
TP53	-1807	1985	-4011	2709
TPP2	2658	7908	-3636	2610
TPR	1846	5115	-1721	4615
TRAF2	40	5279	-2998	5763
TRAF3	-3088	3505	-2224	7206
TRAF6	878	6544	-562	-71
TRAF7	-4564	3290	4353	4600
TRAIP	-193	4069	-3254	2585
TRAPPC1	-1916	3999	3336	5232
TREML2	-2351	162	3247	-1968
TREX1	1500	2324	592	-1434
TRIB3	-565	560	-565	3767
TRIM11	-3856	5392	-247	5178
TRIM14	140	1699	905	1982
TRIM2	-2871	2374	-3794	646
TRIM21	3284	-41	2994	-1671
TRIM22	4119	1099	419	2278
TRIM25	1951	6633	4223	446
TRIM26	-364	4586	2045	3540
TRIM35	-2740	4825	-4337	1556
TRIM36	3687	3012	790	-1285
TRIM37	931	5171	-1982	3725
TRIM38	4208	5505	2662	4882
TRIM39	-2276	6667	-2227	6696
TRIM4	-1089	8222	-3571	7141
TRIM41	-3198	6375	3849	7009
TRIM45	448	5168	-3327	-1040
TRIM46	-221	3178	-3184	3136
TRIM5	4187	5670	1797	395
TRIM56	1413	2971	-1165	5738
TRIM62	-1441	6587	-654	3890
TRIM68	-1855	-333	-3500	-539
TRIM8	-2686	4622	4202	6373
TRIM9	853	2438	2620	3459
TRIP12	801	7691	3067	6253
TRPC1	1888	4746	-3667	-631
TRPM2	-2751	7757	4355	-1792
TSPAN14	-2003	917	4079	4962
TUBB	-357	3701	-2272	6246
TUBB4B	-2428	6398	2462	7160
TXK	-3364	2757	-4527	4859
TXLNA	937	8130	839	7005
TXN	1873	336	3237	-1733
TXNDC5	2037	7500	-1760	-1871
TXNIP	4106	3959	-1903	6152
TYK2	-2482	1902	4365	4072
TYROBP	-1849	830	4152	-1995
UBA3	4072	719	3656	4052
UBA5	3394	3494	-1850	911
UBA52	-3208	4386	-596	-69
UBA6	4397	2569	1378	-917
UBA7	-1691	3029	575	-1589
UBAC1	-2684	1747	3877	-157
UBB	-2084	561	-996	5058
UBC	-1739	2624	1876	3220
UBE2B	4219	3310	7	5146
UBE2C	-167	1577	-861	4534
UBE2D1	1930	4687	3454	2741
UBE2D2	-56	4255	-1159	2134
UBE2D3	3202	2444	2392	3005
UBE2D4	3008	-543	-2854	915
UBE2E1	3227	3136	113	2408
UBE2E2	410	6892	-1061	2070
UBE2E3	377	666	279	-777
UBE2F	-1448	7563	2817	6895
UBE2G1	1835	3441	589	214
UBE2G2	-3900	6380	-3698	6797
UBE2H	-391	3411	1847	1146
UBE2J1	2637	4265	2804	1013
UBE2J2	-2941	8148	2849	6011
UBE2K	3615	7162	1074	3260
UBE2L3	3050	-485	2085	119
UBE2L6	2934	760	-3002	1295
UBE2M	-4705	5150	1539	2052
UBE2N	3397	6741	-1303	4833
UBE2O	-3863	7207	-1448	6885
UBE2Q1	102	3122	1177	2054
UBE2Q2	2723	853	-4396	-223
UBE2R2	-146	-87	3597	-1207
UBE2S	-993	-545	895	-706
UBE2V1	2034	4568	-1420	2792
UBE2V2	3825	5511	-976	3547
UBE2W	3586	7009	1318	5412
UBE2Z	-812	2929	-2680	6569
UBE3A	3137	620	-1629	2812
UBE3B	-1782	4195	3105	709
UBE3C	-835	8320	49	6989
UBE3D	1681	-825	-3012	-1595
UBOX5	-1005	3105	2159	5846
UBR1	1954	2209	-471	460
UBR2	2359	4111	2550	2591
UFL1	3648	4025	-1544	3864
UNC13D	-3097	481	4403	-1904
UNC93B1	100	8116	4277	4748
UNKL	-1933	528	833	-1601
USP18	4340	-385	-2548	-1012
VAMP2	258	533	-3262	-1237
VAMP3	1811	2454	2982	619
VAMP8	-2659	3376	1656	868
VAPA	2045	3824	3031	4245
VASP	-1291	3413	3718	1142
VAT1	-3926	1426	4292	-1357
VAV1	-2612	6923	3874	5832
VAV2	-832	7700	2796	4133
VAV3	-4054	8267	2141	-685
VCL	-1153	1830	476	3614
VCP	-2285	7849	1665	1908
VEGFA	-3059	827	1628	87
VHL	-1365	2716	227	5208
VIM	-1688	3605	4349	3780
VRK3	1695	5188	2478	2903
VTN	-210	2502	1272	-1925
WASF1	-547	758	4502	-830
WASF2	-2160	1232	3929	-134
WASL	2751	7375	-567	4644
WIPF1	-2325	2893	-1463	-784
WIPF2	655	565	2515	-1017
WSB1	4440	4563	4190	4174
WWP1	3419	4683	-4565	479
XAF1	4429	4678	-1243	-1462
XRCC5	1691	3512	-1013	1327
XRCC6	661	2803	-3543	3282
YES1	677	-619	-2471	5197
YPEL5	1717	-147	2447	3986
YWHAB	4207	4074	788	2152
YWHAZ	3562	2726	-278	4293
ZAP70	-4216	1398	-4044	7248
ZBP1	3229	515	-2798	7174
ZBTB16	-4455	6498	1895	-42
ZEB1	325	6286	-3849	5935
ZNRF1	-3998	5267	-930	-819
ZNRF2	-2764	558	-2334	3277

---

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

metric	value
setSize	85
pMANOVA	1.04e-21
p.adjustMANOVA	5.26e-20
s.dist	0.65
s.t0_crp_RNA	-0.339
s.t0_crp_meth	-0.0914
s.pod_crp_RNA	-0.507
s.pod_crp_meth	0.205
p.t0_crp_RNA	6.85e-08
p.t0_crp_meth	0.146
p.pod_crp_RNA	6.97e-16
p.pod_crp_meth	0.00113

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938
RPS23	-3858	-3376
RPL38	-2941	-4417

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
FAU	-4223	5971	-437	6875
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPN1	-2677	6556	1584	6051
RPN2	1722	3783	2658	5500
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
SEC11A	375	6689	2678	5766
SEC11C	4087	5323	-2282	4500
SEC61A1	-402	5868	1559	421
SEC61A2	3544	6636	-1344	301
SEC61B	-1073	453	1749	6422
SEC61G	4221	2858	-947	1928
SPCS2	4182	7859	-999	6692
SPCS3	4075	4006	-748	1497
SRP14	2388	5802	1918	5762
SRP19	4175	1184	-211	5844
SRP54	4528	3625	2414	4032
SRP68	1655	264	-1049	4339
SRP72	2333	2257	-2052	307
SRPRB	2385	2070	-3958	6603
SSR1	2718	94	-1086	3856
SSR2	748	1243	-958	-133
SSR3	3028	21	-286	-75
TRAM1	3613	631	-3620	906
UBA52	-3208	4386	-596	-69

---

---

Influenza Infection

Influenza Infection

metric	value
setSize	128
pMANOVA	1.43e-21
p.adjustMANOVA	6.9e-20
s.dist	0.535
s.t0_crp_RNA	-0.233
s.t0_crp_meth	-0.0297
s.pod_crp_RNA	-0.434
s.pod_crp_meth	0.207
p.t0_crp_RNA	5.78e-06
p.t0_crp_meth	0.564
p.pod_crp_RNA	2.76e-17
p.pod_crp_meth	5.63e-05

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
RPL27A	-3904	-4061
RPS3	-4143	-3753
RPS27A	-4078	-3731
RPS16	-3448	-4379
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723
RPL35	-3508	-3999
RPS29	-3034	-4598
RPS18	-3284	-4218
RPS6	-4317	-3204
RPL18A	-3444	-3938
RPS23	-3858	-3376
RPL38	-2941	-4417

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
AAAS	-638	2718	243	1467
CALR	1148	3542	1904	5712
CANX	1285	7328	-533	3479
CLTA	185	1469	2876	-546
CLTC	461	2670	3511	7256
CPSF4	-3531	7169	-943	1770
DNAJC3	2858	8289	3092	6470
EIF2AK2	4506	187	169	683
FAU	-4223	5971	-437	6875
GRSF1	1523	1467	-1290	4315
GTF2F1	-4236	1342	2079	558
GTF2F2	2000	4258	2006	5306
HSP90AA1	3100	4857	-2176	6208
HSPA1A	-3490	1106	2517	-920
IPO5	-775	8332	-4676	4874
ISG15	3651	-537	-3046	6539
KPNA1	2982	6152	-1803	4422
KPNA2	2320	838	-1587	4420
KPNA3	3326	1397	-1791	4399
KPNA4	3677	8123	-297	4999
KPNA5	3718	1682	-3426	1847
KPNB1	2659	5901	-47	1140
NDC1	-28	-272	-4667	6480
NUP107	2943	1017	-4115	6299
NUP133	2030	1473	-2474	935
NUP153	1372	7264	-1870	4343
NUP155	1163	5083	-3460	3043
NUP160	1232	5781	-4066	1293
NUP188	-2474	591	-3287	2922
NUP205	1308	370	-3162	1670
NUP210	-4099	775	-1841	690
NUP214	779	7322	3866	4368
NUP35	3287	7567	-4566	-557
NUP37	1488	500	-594	3398
NUP43	3972	139	-3557	6344
NUP50	2599	5772	-517	6704
NUP54	4432	6517	-2306	831
NUP62	-1277	2703	156	4608
NUP85	2428	5395	-713	4517
NUP88	1692	6430	-4454	7082
NUP93	1140	7850	-1307	2006
NUP98	808	1649	64	-747
PABPN1	-2016	7253	994	3061
PARP1	-2044	374	-4291	3582
POLR2A	-2661	-175	2387	4046
POLR2B	2791	1490	-2187	5561
POLR2C	-1223	4488	-1052	6354
POLR2D	1826	1345	-3754	-614
POLR2E	-4070	2983	1998	3712
POLR2F	-4130	6520	2177	509
POLR2G	-3529	8023	2161	1604
POLR2H	-1987	7555	-1495	6297
POLR2I	-4150	6339	-662	5655
POLR2K	3699	2452	-1615	3853
POM121	-4007	5147	-934	4680
POM121C	-4243	5643	-2686	2061
RAE1	2280	705	1931	2634
RAN	1899	2279	-3437	1483
RANBP2	2136	4418	-1280	5164
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
SEC13	-1298	7330	2552	6209
SEH1L	3665	6621	-4109	3577
TGFB1	-3576	4335	-268	3769
TPR	1846	5115	-1721	4615
UBA52	-3208	4386	-596	-69
XPO1	4384	5608	-1759	6845

---

---

Metabolism of RNA

Metabolism of RNA

metric	value
setSize	535
pMANOVA	3.65e-20
p.adjustMANOVA	1.69e-18
s.dist	0.257
s.t0_crp_RNA	0.00411
s.t0_crp_meth	-0.0412
s.pod_crp_RNA	-0.234
s.pod_crp_meth	0.0964
p.t0_crp_RNA	0.873
p.t0_crp_meth	0.11
p.pod_crp_RNA	7.18e-20
p.pod_crp_meth	0.000176

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	pod_crp_meth
RPS2	-4571	6973
GEMIN4	-4634	6847
TSR1	-4621	6837
NUP88	-4454	7082
RPL3	-4610	6751
RPS3A	-4365	7066
NDC1	-4667	6480
RPL7	-4292	7008
CNOT6L	-4280	6260
NUP107	-4115	6299
SNU13	-3664	7052
RPL34	-3944	6513
UPF3A	-3579	6961
SNRNP40	-3947	6267
RPS5	-4065	6070
RPS12	-3896	6329
RPLP2	-3815	6421
PRPF19	-3975	6015
WDR43	-4139	5508
ALKBH8	-4555	5002

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
AAAS	-638	2718	243	1467
ACTB	-373	4248	4005	5446
ADAR	2970	5925	1386	3087
ADARB1	-688	6467	-376	-972
ADAT1	-412	2989	-729	5557
ADAT2	3166	6235	-2841	3497
ADAT3	-3388	1349	2580	6332
AKT1	-4471	4213	2297	1109
ALKBH8	1400	2312	-4555	5002
ALYREF	-2943	3402	-1458	6735
ANP32A	805	3037	4023	1765
AQR	2807	380	502	-1469
BMS1	-1273	279	-4313	-1753
BUD31	408	4772	2077	2740
BYSL	-2328	5900	-2573	6806
C1D	4279	3651	206	2322
C2orf49	4203	4767	-2130	2636
CASC3	-2211	3328	2647	5105
CCAR1	4043	6118	-658	4000
CCNH	4319	5970	2670	1260
CD2BP2	-3008	1794	3407	-544
CD44	498	4392	3154	4897
CDC40	3487	3340	1326	7122
CDC5L	3354	978	503	-742
CDK7	3836	3659	1886	4034
CDKAL1	3223	-182	-2347	4216
CHERP	-4093	6140	-1173	2907
CLNS1A	3455	5265	-2574	-278
CLP1	-616	2944	1426	2378
CNOT1	-24	2748	-442	4958
CNOT10	1906	1981	-852	3018
CNOT11	2653	2636	493	3729
CNOT3	-2438	3446	3132	3093
CNOT4	4218	2243	-1242	5999
CNOT6	3521	6031	1641	4652
CNOT6L	-926	4317	-4280	6260
CNOT7	4102	6482	-4009	-58
CNOT8	2112	5181	-110	5796
CPSF1	-1060	6585	1861	1083
CPSF2	3577	2290	1770	988
CPSF3	2898	-399	2488	5336
CPSF4	-3531	7169	-943	1770
CRNKL1	2014	8025	-1493	5504
CSNK1D	-4441	6564	2787	3046
CSNK1E	-3951	7015	-3414	3000
CSTF1	4	6872	-3334	6207
CTNNBL1	-380	6381	1764	2615
CTU1	-4059	3389	1313	4161
CTU2	-3153	7833	-1746	7024
CWC15	3150	6685	211	-1125
CWC22	4404	5009	-1699	4010
CWC27	4385	3882	-379	-818
DCAF13	-562	1410	-1783	862
DCP1A	2646	4253	-3323	5068
DCP1B	-1055	5081	-4312	2554
DCP2	3639	-278	1475	5675
DCPS	-3749	4073	885	5059
DDX1	3120	1220	-2520	2193
DDX20	2214	5336	-4275	3954
DDX21	2972	7462	-1540	3312
DDX23	-1250	7546	2286	2707
DDX42	331	955	-966	1669
DDX46	2790	4721	321	2158
DDX47	4326	892	-3647	-50
DDX49	-4479	3907	1633	5580
DDX5	-772	1742	-1573	1804
DDX52	4531	3595	579	-204
DDX6	1045	3344	-1725	2014
DHX16	-3517	2815	-566	3127
DHX37	-3145	6236	-2526	4194
DHX9	243	6405	-2418	5545
DIS3	4375	4884	-1622	-754
DNAJC8	3588	904	-863	861
DUS2	-800	5712	2301	710
EBNA1BP2	-556	1401	-3067	6233
EDC3	-3346	4400	696	3531
EDC4	-3747	2267	-1262	-1376
EFTUD2	-1290	8218	3157	2652
EIF4A1	568	5332	2238	881
EIF4A2	3750	5307	-4415	3601
EIF4A3	-2476	5309	-384	4597
EIF4B	-2849	3070	-3855	5585
EIF4E	4474	5594	818	6719
EIF4G1	-3029	3207	3785	5764
ELAC2	-936	5459	-1517	275
ELAVL1	323	6880	-2626	1665
ENPP2	1354	7463	1224	3897
ERCC2	-2656	1778	3047	1849
ERCC3	223	3545	2049	1487
ERI1	3766	-203	768	-139
ETF1	3017	7097	1676	151
EXOSC1	2149	7237	992	316
EXOSC10	1827	1777	-2188	802
EXOSC2	-3836	-378	-3761	5343
EXOSC3	851	4957	110	3245
EXOSC4	-2860	5195	3343	64
EXOSC5	-3756	469	-3823	790
EXOSC6	-1352	3467	-3661	1534
EXOSC7	-4443	4094	-2938	-158
EXOSC8	3032	5356	-3616	1364
FAM98B	4390	3565	-2355	2205
FAU	-4223	5971	-437	6875
FBL	-4678	-91	-4594	-43
FCF1	2808	5725	-1239	6761
FIP1L1	858	2985	-1642	3099
FTSJ3	-2540	4963	1385	4235
FUS	-1127	1056	-114	5261
FYTTD1	2371	4178	-3394	5126
GAR1	-224	3758	-2986	879
GCFC2	3865	-584	-4195	-1739
GEMIN2	3762	-768	-338	-290
GEMIN4	-2701	6849	-4634	6847
GEMIN5	-1157	-107	-3290	1695
GEMIN6	1303	413	-1162	-1085
GEMIN7	-1960	357	1850	-388
GLE1	-902	5878	2109	1687
GNL3	2241	1853	-4428	1201
GSPT1	2757	4351	-2932	-1153
GTF2F1	-4236	1342	2079	558
GTF2F2	2000	4258	2006	5306
GTF2H3	1068	8239	-3652	5703
GTF2H4	-995	6151	892	5239
GTF2H5	1838	1881	-279	3417
GTPBP3	-3480	5098	-1878	1640
HBS1L	2688	488	-1585	598
HEATR1	566	6362	-3326	5200
HNRNPA0	-4722	567	-4225	3059
HNRNPA2B1	1271	2586	2367	2721
HNRNPC	1732	735	1301	213
HNRNPD	-3228	2603	-1020	-667
HNRNPF	-3188	3524	-532	5855
HNRNPH1	1863	2157	-1951	2373
HNRNPK	707	5598	1024	3141
HNRNPL	-4107	3364	2180	6117
HNRNPM	-1989	6919	1257	2773
HNRNPR	318	4894	-3603	4902
HNRNPU	-1010	5652	-328	4166
HNRNPUL1	-4608	3099	-386	2869
HSPA1A	-3490	1106	2517	-920
HSPB1	-1006	2000	-832	883
IGF2BP3	995	3852	979	-734
IMP3	-1621	6086	-3137	5540
IMP4	-2501	4256	-3803	3786
ISG20L2	530	2755	-15	6436
ISY1	-3327	2040	-615	1885
KHSRP	-2305	835	218	1774
KRR1	2893	-801	-2865	-1950
LCMT2	-1284	4334	-3407	6262
LSM1	662	2876	450	5932
LSM10	-587	4321	2838	1062
LSM11	-3574	2770	-4485	-211
LSM2	-1262	6168	-975	5946
LSM3	2146	2589	6	2560
LSM4	-2717	3989	-2478	-239
LSM5	2291	5599	-3717	4273
LSM6	-1990	6676	2048	2778
LSM7	-4507	5117	-2390	689
LSM8	1677	3014	-2031	-1734
LTV1	2852	2898	-1941	2915
MAPK14	1563	2227	4024	2465
MAPKAPK2	-3939	1416	2421	3265
METTL1	-674	6979	-4164	4405
METTL14	4473	6571	-1356	-834
MNAT1	2008	2598	-2465	1516
MPHOSPH10	4488	5449	-2942	5400
MPHOSPH6	1961	6222	-949	5533
MRM1	-2461	2109	-3228	-159
MTERF4	-2411	5813	-4491	3503
MTO1	3388	1501	-2461	396
NCBP1	4110	6523	-472	5857
NCBP2	4266	3714	-3787	4776
NCL	-1980	6791	-4315	5053
NDC1	-28	-272	-4667	6480
NHP2	-3191	6971	-2519	4826
NIP7	1970	5730	-3733	4218
NOB1	-2719	-262	-4364	2003
NOC4L	-1413	5509	2788	-799
NOL11	3694	-390	-4414	2571
NOL12	-297	5999	2186	-1549
NOL6	-4372	6081	-3107	4556
NOL9	1673	-787	-3236	-1444
NOP10	-1724	2394	4174	2081
NOP14	-2035	-731	-4619	2209
NOP2	-3532	5036	-2782	6401
NOP56	-390	117	-3865	996
NOP58	3566	2112	-4420	1333
NSUN2	3540	-108	1947	2230
NSUN4	1766	777	1615	3316
NSUN6	3919	4433	887	2767
NUDT21	2631	5030	-4023	4270
NUP107	2943	1017	-4115	6299
NUP133	2030	1473	-2474	935
NUP153	1372	7264	-1870	4343
NUP155	1163	5083	-3460	3043
NUP160	1232	5781	-4066	1293
NUP188	-2474	591	-3287	2922
NUP205	1308	370	-3162	1670
NUP210	-4099	775	-1841	690
NUP214	779	7322	3866	4368
NUP35	3287	7567	-4566	-557
NUP37	1488	500	-594	3398
NUP43	3972	139	-3557	6344
NUP50	2599	5772	-517	6704
NUP54	4432	6517	-2306	831
NUP62	-1277	2703	156	4608
NUP85	2428	5395	-713	4517
NUP88	1692	6430	-4454	7082
NUP93	1140	7850	-1307	2006
NUP98	808	1649	64	-747
NXF1	116	1942	2995	1236
NXT1	-4177	660	-3979	4712
PABPC1	1721	3723	-1442	3011
PABPN1	-2016	7253	994	3061
PAIP1	2851	-396	-2429	6165
PAN2	612	2144	704	-743
PAN3	3983	-799	473	1365
PAPOLA	3033	3883	812	4316
PARN	1656	5124	-1817	5478
PATL1	3730	6832	3899	-473
PCBP1	-3489	1810	1951	865
PCBP2	-2726	1016	-881	3201
PDCD11	-2808	1973	-3660	3455
PDCD7	-1044	7505	-2726	3569
PELP1	-637	6658	-3306	2742
PES1	-4103	222	-2386	3288
PHAX	1907	2467	-4010	5543
PLRG1	4225	5663	-3030	5210
PNO1	2611	1456	-3399	6494
PNRC2	4481	3773	-2191	5676
POLDIP3	-1158	1386	3841	3182
POLR2A	-2661	-175	2387	4046
POLR2B	2791	1490	-2187	5561
POLR2C	-1223	4488	-1052	6354
POLR2D	1826	1345	-3754	-614
POLR2E	-4070	2983	1998	3712
POLR2F	-4130	6520	2177	509
POLR2G	-3529	8023	2161	1604
POLR2H	-1987	7555	-1495	6297
POLR2I	-4150	6339	-662	5655
POLR2K	3699	2452	-1615	3853
POM121	-4007	5147	-934	4680
POM121C	-4243	5643	-2686	2061
POP1	-1496	5074	-1937	3613
POP4	740	397	-194	1072
POP5	-1211	1292	-2208	5987
POP7	-2981	3488	376	3070
PPIE	1995	6743	-2167	6025
PPIH	-1482	3640	-3512	2129
PPIL1	1884	-329	-3217	-1624
PPIL3	2468	6728	-1039	375
PPIL4	4373	5682	-1571	-164
PPIL6	564	1721	1174	147
PPP2CA	2133	7688	1877	2598
PPP2R2A	4508	542	-554	-752
PPWD1	4053	5829	-2387	-1683
PRCC	-3932	3938	1652	2255
PRKCA	-2583	7972	-2473	6892
PRKCD	301	8167	4500	6358
PRMT5	735	1328	678	2005
PRPF19	-4460	6581	-3975	6015
PRPF3	2501	5430	-558	1089
PRPF31	-4209	1107	-874	3855
PRPF38A	3351	3209	-1378	5305
PRPF40A	4315	-724	-171	5626
PRPF6	-1594	5822	-3191	4284
PRPF8	-3675	2300	-2834	516
PSMA1	2917	5206	1363	4758
PSMA2	1509	4929	-836	5163
PSMA3	4416	1432	-1823	3586
PSMA5	3047	4175	-2828	3319
PSMA6	3897	6144	1661	6676
PSMA7	-246	5863	3266	6901
PSMB1	-371	2981	-803	5409
PSMB10	-3433	689	-161	6388
PSMB2	835	-501	1803	1518
PSMB3	23	780	3778	4305
PSMB5	-2694	183	3229	269
PSMB6	-3103	5638	3472	5817
PSMB7	-2378	1587	2955	4198
PSMB8	949	1746	2054	5155
PSMB9	-217	3058	-3454	4468
PSMC1	928	2242	2194	1413
PSMC3	-2624	4680	847	736
PSMC4	-1230	1188	537	3431
PSMC5	-1694	2039	-2600	5094
PSMC6	4108	118	1373	2356
PSMD1	2911	5546	2375	56
PSMD11	4009	2032	2637	3521
PSMD12	4511	5250	2167	3681
PSMD13	-998	7807	1482	561
PSMD14	3360	3896	85	6314
PSMD2	-3334	6719	2097	3610
PSMD3	-4637	3063	1629	5579
PSMD4	-1530	1685	3940	5313
PSMD6	1854	3171	3275	2336
PSMD7	3595	864	596	2079
PSMD8	-2435	7747	2069	4665
PSMD9	-3510	-186	3384	3375
PSME1	1353	7210	-2849	1614
PSME2	3304	7208	-1478	778
PSME3	802	6539	2470	5231
PSME4	3349	7885	-461	5908
PSMF1	-1946	2260	416	7179
PTBP1	-4071	1931	-1813	815
PUF60	-4603	1818	-537	2049
PUS1	-4472	3146	-2205	4829
PUS3	4012	-785	137	965
PUS7	1768	1476	-4163	5386
PWP2	-3288	3400	-3239	5075
QTRT1	-3112	5428	-3348	5787
RAE1	2280	705	1931	2634
RAN	1899	2279	-3437	1483
RANBP2	2136	4418	-1280	5164
RBM17	-139	125	-2810	2268
RBM28	-2460	5591	-2557	3412
RCL1	-2020	7155	-3537	6341
RIOK1	2656	7804	-1376	6496
RIOK2	3564	1632	-3897	1638
RIOK3	3495	2135	1073	3472
RNGTT	2340	1731	365	14
RNMT	3322	2739	-2660	6869
RNPC3	3106	5899	-644	3737
RNPS1	-2473	2186	-3151	537
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPP14	3290	6084	-993	2236
RPP21	-3292	6702	-86	2599
RPP25	-2510	7139	-3453	5743
RPP30	3476	4936	-3223	668
RPP38	3369	1308	-2914	4779
RPP40	1457	2935	-4562	570
RPPH1	2032	1749	4352	5011
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
RRP1	-894	4246	340	5199
RRP7A	-281	3244	-1932	1582
RRP9	-4587	-253	-3731	653
RTCB	1219	416	331	-1471
SART1	-3402	482	1700	5775
SEC13	-1298	7330	2552	6209
SEH1L	3665	6621	-4109	3577
SENP3	-1093	8054	1649	5393
SET	352	2248	-3641	-1665
SF1	-2539	3369	-467	2873
SF3A1	-2918	8134	-2591	6185
SF3A2	-4312	-383	-2184	7182
SF3A3	-2055	4848	-3066	4520
SF3B2	-847	2397	1002	2483
SF3B3	-598	1890	-4108	423
SF3B4	-216	3549	1564	1093
SF3B5	-3549	6439	258	2879
SKIV2L	-2073	5609	2066	6257
SLBP	2900	6823	-2054	428
SLU7	4019	1803	-717	1094
SMG1	55	8307	-687	4788
SMG5	-2955	-215	-767	5172
SMG6	-2359	-678	-1874	6205
SMG7	1612	3107	3551	2361
SMG8	2347	7988	255	1691
SMNDC1	3918	7085	734	3512
SNRNP200	-3395	4541	-2684	1391
SNRNP25	-2875	1878	257	2891
SNRNP27	3367	3603	-503	1452
SNRNP35	2600	3064	3019	-1466
SNRNP40	2940	3644	-3947	6267
SNRNP48	4525	-392	-2439	-1044
SNRNP70	-3105	5169	-2380	2532
SNRPA	518	677	1350	1269
SNRPA1	1550	6067	-2069	1539
SNRPB	-2032	7594	-1468	4947
SNRPB2	3877	5793	-991	1876
SNRPC	-675	1741	-266	3152
SNRPD1	3006	922	-1546	4844
SNRPD2	-4245	412	-2029	-551
SNRPD3	795	6797	-1853	-377
SNRPE	175	5854	-3125	3730
SNRPG	3070	6466	1508	3411
SNRPN	778	-761	-4134	-1422
SNU13	-1800	-638	-3664	7052
SNUPN	2165	944	1885	2739
SNW1	3539	3975	580	2517
SRRM1	4398	6138	-860	3813
SRRM2	-1817	-706	1249	-214
SRRT	-1902	844	-1354	1308
SRSF10	2268	6868	-3534	2085
SRSF11	2689	7829	-3580	-51
SRSF2	464	3247	-2180	212
SRSF3	3264	185	-2400	-1223
SRSF4	383	-515	2645	6865
SRSF7	2068	4748	-1973	618
SRSF9	-643	8057	3465	745
SUPT5H	-3482	5357	-1088	2020
SYF2	2727	7292	366	4211
SYMPK	70	3596	1744	2886
TBL3	-3751	5261	19	5417
TEX10	3497	-297	-4086	1204
TFB1M	2498	2147	-1945	1831
TFIP11	-272	979	1457	936
THADA	2308	5765	-2192	4243
THG1L	646	1004	-2804	2917
THOC1	3589	7129	-2135	6021
THOC5	955	4206	3843	3364
THOC7	4273	3728	538	5592
THUMPD1	3126	1431	-4395	-871
TNFSF13	-1161	5409	4326	-1362
TNKS1BP1	-3500	1203	-3259	3401
TNPO1	1745	4371	-1447	4634
TP53RK	-53	6071	-4127	2847
TPR	1846	5115	-1721	4615
TPRKB	3066	6491	-3202	3473
TRDMT1	2332	1428	1364	-401
TRIT1	2084	1364	-706	6753
TRMT1	-2480	1484	-1428	-744
TRMT10A	3258	-520	2701	1313
TRMT11	4252	5292	-4277	2032
TRMT112	-4008	7769	-160	1929
TRMT12	-1483	-493	-404	-1651
TRMT44	-1611	-652	-1212	-1514
TRMT6	2833	8190	2076	3940
TRMT61A	-4648	4946	-3147	3423
TRMT61B	135	4498	-3497	5387
TRMU	3	6858	-931	6385
TRNT1	4380	1236	-1054	4674
TSEN15	3597	1028	-3168	502
TSEN2	409	5795	-3165	3306
TSEN34	-3161	7397	2828	1820
TSEN54	-2123	1399	-3716	591
TSR1	-341	6406	-4621	6837
TSR3	-4199	1625	-151	6368
TTC37	1359	-69	-3103	334
TXNL4A	-3023	-315	2464	2176
TYW1	85	3702	-4257	2393
TYW3	2638	3986	-3574	985
TYW5	3041	7677	238	3607
U2AF1	-276	6502	1471	1030
U2AF1L4	-1709	-451	387	5614
U2AF2	-4347	6388	346	6130
U2SURP	4202	7945	-1911	6590
UBA52	-3208	4386	-596	-69
UBB	-2084	561	-996	5058
UBC	-1739	2624	1876	3220
UPF1	-2902	707	2612	5956
UPF2	3948	4005	-99	3840
UPF3A	-1847	6389	-3579	6961
URM1	-4463	2771	354	3783
USP39	-1523	3707	236	5624
UTP15	4103	2192	-3831	5062
UTP18	1555	4515	1472	3357
UTP20	2389	4984	-3079	5084
UTP3	-823	5891	-608	3926
UTP6	3752	1891	-2359	3932
WBP11	-105	1393	-4057	986
WBP4	4410	7066	906	1882
WDR12	2088	2282	-541	6792
WDR18	-2689	2119	-1828	-1077
WDR3	-11	550	-3655	-1385
WDR33	2305	7055	-106	3468
WDR36	2325	4898	-2570	6599
WDR43	1173	2125	-4139	5508
WDR61	1345	2434	-528	1522
WDR75	2774	3709	-4340	4613
WDR77	1111	-644	-3122	2831
WTAP	3512	5997	-217	3489
XAB2	-3401	44	-244	1760
XPO1	4384	5608	-1759	6845
XPOT	2657	-75	-2853	2981
XRN1	2444	-176	-1395	-1959
XRN2	1078	2908	3514	-29
YBX1	-2060	4522	-183	6423
YWHAB	4207	4074	788	2152
YWHAZ	3562	2726	-278	4293
ZBTB8OS	2630	4877	3387	266
ZCRB1	3551	2597	-638	438
ZFP36	-4681	-334	-7	5099
ZFP36L1	807	873	2458	5470
ZMAT5	-1981	1503	3944	6882

---

---

Translation

Translation

metric	value
setSize	234
pMANOVA	7.39e-19
p.adjustMANOVA	3.3e-17
s.dist	0.366
s.t0_crp_RNA	-0.117
s.t0_crp_meth	-0.0878
s.pod_crp_RNA	-0.332
s.pod_crp_meth	0.0473
p.t0_crp_RNA	0.0023
p.t0_crp_meth	0.0217
p.pod_crp_RNA	3.1e-18
p.pod_crp_meth	0.216

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_RNA
RPS2	-4571	-4698
RPL3	-4610	-4508
EEF1G	-4201	-4651
EEF1B2	-4265	-4461
RPLP2	-3815	-4667
RPS5	-4065	-4113
RPS12	-3896	-4261
RPLP0	-4060	-4068
EIF3B	-4157	-3948
RPL27A	-3904	-4061
RPS3	-4143	-3753
EEF1A1	-4432	-3462
RPS27A	-4078	-3731
RPS16	-3448	-4379
MRPL24	-3333	-4510
EIF3L	-3540	-4194
EEF2	-3170	-4680
RPL29	-3643	-3990
RPS10	-3457	-4168
RPL37	-2971	-4723

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
AARS2	-3561	2830	-3482	952
AIMP2	-1469	5991	-1076	5641
APEH	-3872	429	1730	832
AURKAIP1	-3221	3867	2067	4898
CARS2	-2017	169	3716	3857
CHCHD1	-2075	3666	2293	5959
DAP3	1306	142	-2649	3981
DARS2	813	8366	1130	-1322
EARS2	-1742	778	-4209	-610
EEF1A1	-3462	2007	-4432	2941
EEF1B2	-4461	5596	-4265	3976
EEF1D	-4492	7623	-2131	5789
EEF1E1	3841	3253	858	-948
EEF1G	-4651	718	-4201	111
EEF2	-4680	1309	-3170	4195
EIF2B1	3618	4999	615	6667
EIF2B2	242	6490	1939	-173
EIF2B3	1210	805	-2084	1141
EIF2B4	-1954	5644	2504	3641
EIF2B5	402	832	-990	5041
EIF2S1	3538	6680	-1389	4744
EIF2S2	3430	5111	116	6252
EIF3A	728	186	-641	5853
EIF3B	-3948	-637	-4157	-704
EIF3E	3043	3996	-4004	503
EIF3F	-4699	1781	-1541	1471
EIF3G	-4429	1815	-692	3038
EIF3H	-554	4996	-2590	3706
EIF3I	-3483	2651	-1095	696
EIF3J	3642	3047	-2652	737
EIF3K	-2643	8378	-128	6634
EIF3L	-4194	6675	-3540	2568
EIF3M	3156	7216	-2454	5834
EIF4A1	568	5332	2238	881
EIF4A2	3750	5307	-4415	3601
EIF4B	-2849	3070	-3855	5585
EIF4E	4474	5594	818	6719
EIF4EBP1	-1882	3825	2028	4397
EIF4G1	-3029	3207	3785	5764
EIF4H	-4464	3662	2777	-1986
EIF5	4129	7119	-179	4312
EIF5B	3653	4185	-2613	4182
ERAL1	160	3760	1207	5756
ETF1	3017	7097	1676	151
FARS2	126	-602	-3956	2999
FARSA	-4291	5681	-613	3072
FARSB	2057	5308	-3451	2500
FAU	-4223	5971	-437	6875
GADD45GIP1	-2749	-348	-723	351
GFM1	634	1358	-4366	1128
GFM2	3768	4065	-155	4208
GSPT1	2757	4351	-2932	-1153
HARS2	4029	1355	1927	2446
IARS2	1574	2673	-1990	3733
LARS2	-3592	1510	-3845	-1560
MARS2	-933	2579	-3728	951
MRPL1	3646	215	-2887	452
MRPL10	1340	2271	2024	-1243
MRPL11	-2767	4018	-2171	3156
MRPL12	-3944	8246	-1413	5432
MRPL13	3843	7598	649	1510
MRPL14	-1974	6324	-1857	-354
MRPL15	411	5025	-1393	5964
MRPL16	1616	7669	1305	350
MRPL18	783	3862	72	4037
MRPL19	2401	6034	-1714	1189
MRPL2	-760	-432	-413	-1975
MRPL20	-1193	-780	728	-1812
MRPL21	-507	1598	478	1490
MRPL22	2992	6243	740	-877
MRPL23	-3807	-844	2509	-547
MRPL24	-4510	445	-3333	1499
MRPL27	-2233	-710	-295	5381
MRPL30	1487	5671	-1731	5640
MRPL32	3171	907	-2419	2250
MRPL33	1956	2846	1892	110
MRPL34	-2909	784	-1610	4946
MRPL35	2703	460	-2795	2146
MRPL36	246	8306	899	6688
MRPL37	-4134	-300	-912	4356
MRPL38	-2885	6604	-2916	-344
MRPL39	3959	4880	-1838	6175
MRPL4	-480	7640	1009	6861
MRPL41	-2642	1533	-1200	1121
MRPL42	4520	3615	-2286	1175
MRPL43	-4256	3485	-1522	1544
MRPL44	3909	2663	870	-911
MRPL45	-38	-660	-2769	5887
MRPL46	714	5102	-3548	2383
MRPL47	3674	6822	-603	4370
MRPL48	1466	5632	-3242	5771
MRPL49	-2700	6784	-3395	4583
MRPL50	3940	3820	-4102	2815
MRPL51	944	-287	1593	-1090
MRPL52	-1623	-146	3167	1666
MRPL53	-2196	964	2786	940
MRPL54	-4248	1882	-2231	3949
MRPL55	-3065	7452	-1490	1428
MRPL57	-570	4229	-1069	-1248
MRPL9	734	-490	-2650	-787
MRPS10	3970	-387	-1388	-184
MRPS11	652	1641	1784	2490
MRPS12	-4224	1705	-1833	-442
MRPS14	4257	1970	-2876	4423
MRPS15	-1259	3663	474	4304
MRPS16	-1717	2532	-153	730
MRPS17	870	3812	-3406	1178
MRPS18A	1636	7668	952	255
MRPS18B	1375	-758	-3887	-1835
MRPS18C	2741	6964	132	3763
MRPS2	-3728	-418	-2708	-101
MRPS21	-2095	1457	-1141	1336
MRPS22	2188	6074	-946	2961
MRPS23	1589	2246	-652	-991
MRPS24	-3827	3363	974	3928
MRPS25	-1840	6241	-3562	175
MRPS26	-4153	8017	-831	6273
MRPS27	690	1414	-3878	-258
MRPS28	729	3699	-1624	3988
MRPS30	-505	5457	-4353	4771
MRPS31	3781	6477	-1716	407
MRPS33	-880	3737	-4153	1674
MRPS34	-4665	6326	-417	5238
MRPS35	4162	3568	-1250	1580
MRPS36	809	2207	528	2055
MRPS5	1138	1121	2227	406
MRPS6	-1915	3312	-4347	3007
MRPS7	-3578	1408	-2136	1187
MRPS9	2016	7533	-2883	5772
MTFMT	143	3556	71	2857
MTIF2	4168	5647	190	886
MTIF3	4086	2047	1565	2044
MTRF1L	3153	2541	1717	2350
N6AMT1	96	323	-4168	62
NARS2	1829	4512	-4407	3408
OXA1L	-577	3011	1697	4016
PABPC1	1721	3723	-1442	3011
PARS2	316	737	-1535	198
PPA1	1780	5	-2379	4283
PPA2	3125	5416	-1176	1044
PTCD3	3448	1336	-1939	1340
RARS2	4091	312	-32	4009
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPN1	-2677	6556	1584	6051
RPN2	1722	3783	2658	5500
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
SARS2	-4671	2710	-2671	4935
SEC11A	375	6689	2678	5766
SEC11C	4087	5323	-2282	4500
SEC61A1	-402	5868	1559	421
SEC61A2	3544	6636	-1344	301
SEC61B	-1073	453	1749	6422
SEC61G	4221	2858	-947	1928
SPCS2	4182	7859	-999	6692
SPCS3	4075	4006	-748	1497
SRP14	2388	5802	1918	5762
SRP19	4175	1184	-211	5844
SRP54	4528	3625	2414	4032
SRP68	1655	264	-1049	4339
SRP72	2333	2257	-2052	307
SRPRB	2385	2070	-3958	6603
SSR1	2718	94	-1086	3856
SSR2	748	1243	-958	-133
SSR3	3028	21	-286	-75
TARS2	3928	2413	2065	2530
TRAM1	3613	631	-3620	906
TRMT112	-4008	7769	-160	1929
TSFM	1881	4991	-1436	3207
TUFM	-3040	1415	2319	4617
UBA52	-3208	4386	-596	-69
VARS2	-2228	2861	-1825	579
WARS2	1984	-77	-3422	3747
YARS2	2400	4102	-1055	2463

---

---

Membrane Trafficking

Membrane Trafficking

metric	value
setSize	436
pMANOVA	2.18e-14
p.adjustMANOVA	9.39e-13
s.dist	0.237
s.t0_crp_RNA	0.0127
s.t0_crp_meth	0.0389
s.pod_crp_RNA	0.233
s.pod_crp_meth	-0.0023
p.t0_crp_RNA	0.654
p.t0_crp_meth	0.169
p.pod_crp_RNA	1.5e-16
p.pod_crp_meth	0.935

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_meth
ARF1	3973	8373
AP1B1	4242	7580
RAC1	4225	7484
TBC1D2	4205	7323
EPN1	4265	6984
GOLIM4	3684	8075
TBC1D10B	3801	7645
TGFA	3789	7641
MVB12A	3677	7835
CHMP2A	4090	6990
SYNJ1	3923	7273
ULK1	4469	6338
RALGAPA2	3740	7363
SEC24D	3967	6653
CLTCL1	3389	7763
GRB2	4230	5972
CBL	3285	7589
GNS	4533	5454
DNM2	3699	6583
GAK	3503	6922

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
AAK1	-307	5697	-3026	2550
ACBD3	957	2079	-263	201
ACTR10	2603	5113	1646	4867
ACTR1A	-1288	879	3846	1932
ACTR2	3144	4932	2747	3844
ACTR3	2753	4481	2482	5950
ADRB2	-1851	5254	-3071	2808
AGFG1	898	4305	3495	4594
AGPAT3	106	-470	3507	637
AKT1	-4471	4213	2297	1109
AKT2	-4622	3462	2041	5430
ALS2CL	-2421	4573	-4523	2557
ANK1	-2221	250	285	947
ANK3	-190	-846	-2640	1579
ANKRD27	-975	5992	811	2102
ANKRD28	-435	7479	-2531	548
AP1B1	-3672	7580	4242	5781
AP1G1	1620	6342	1504	2214
AP1G2	-780	2265	188	-226
AP1M1	-4217	2143	3873	1777
AP1S3	938	5055	686	1942
AP2A1	-2927	1888	4575	-316
AP2M1	-4018	5714	2737	3723
AP2S1	-1597	3981	3589	6037
AP3B1	657	2417	2046	3782
AP3S1	2086	8165	1215	6509
AP4B1	576	5745	490	1635
AP4E1	1459	4969	1100	1918
AP4M1	-245	-818	3840	6148
AP4S1	3958	5921	-779	6581
APP	-1029	7569	1303	6621
ARCN1	860	5980	657	-399
ARF1	-3573	8373	3973	-1819
ARF3	-2676	4360	3215	274
ARF4	3479	2557	3434	4619
ARF5	-2924	2625	3626	-939
ARF6	-1265	6257	-355	3741
ARFGAP1	-2602	2665	2283	6819
ARFGAP3	3528	7016	1360	724
ARFIP2	-1668	7489	-849	-113
ARFRP1	-3305	4052	-1900	6544
ARL1	4386	4709	-1381	2168
ARPC2	1775	5683	3457	2292
ARPC3	2785	4820	3580	3208
ARPC5	2109	2335	3836	2611
ARRB1	-3738	3174	2221	-1276
ARRB2	-2258	4618	4280	2913
ASPSCR1	-3829	6713	-148	5822
BET1	3509	2475	-2271	1788
BET1L	-1184	5185	-1408	4144
BICD1	771	3591	-1010	2613
BICD2	-4553	3563	3233	556
BIN1	-3206	-525	-3859	617
BLOC1S1	-3436	5018	4433	-817
BLOC1S3	-1098	3881	-961	6141
BLOC1S6	1619	1296	-635	4817
BNIP1	2859	6479	-2060	4079
C2CD5	4529	8413	-759	6925
CALM1	1287	3980	-2201	4501
CAPZA1	4166	7801	2992	999
CAPZA2	3798	3735	2976	4666
CAPZB	-747	3052	3210	-308
CBL	-1090	7589	3285	1012
CCZ1	1836	4385	3314	-1868
CD3D	799	-531	-4088	7271
CD4	-528	5984	-2076	909
CD55	1738	3285	4145	1455
CD59	-1703	4468	-1328	-1682
CENPE	4361	2608	751	-74
CHMP2A	-1768	6990	4090	5361
CHMP2B	4107	5724	-169	1684
CHMP3	1129	-59	2516	3694
CHMP4A	1969	1766	2505	4137
CHMP4B	-2750	4108	4089	5510
CHMP5	4239	1915	3667	4369
CHMP6	-4088	1554	2508	2702
CHMP7	-1133	6914	-4438	6062
CLINT1	1393	2370	437	-1927
CLTA	185	1469	2876	-546
CLTB	-3946	595	3085	-918
CLTC	461	2670	3511	7256
CLTCL1	-2388	7763	3389	4510
CNIH1	-1141	-831	-1304	6432
COG1	-60	-288	-2338	922
COG2	2417	4037	-1211	-1011
COG3	3473	939	-1582	755
COG4	4111	3504	3396	645
COG5	4286	409	272	2084
COG6	2817	5686	-2392	3686
COG7	4381	3387	4493	3161
COG8	-2327	5515	-557	2377
COPA	-345	1659	3754	5454
COPB1	4354	2889	2313	2637
COPB2	2955	6063	2519	3476
COPE	-4232	6600	3298	434
COPS2	4242	-444	-219	6454
COPS3	3525	4677	-321	1714
COPS4	1765	3598	-1111	5824
COPS5	3093	1002	1206	3236
COPS6	-2086	3313	353	782
COPS7A	-2164	503	3256	-66
COPS7B	155	6760	95	5098
COPS8	3726	5525	-3738	-1150
COPZ1	1494	1151	1143	97
COPZ2	-2278	3415	-2800	-1670
CPD	-503	2484	3795	-1838
CSNK1D	-4441	6564	2787	3046
CTSC	2238	2310	3599	1311
CTSZ	-1191	-74	4162	-1978
CUX1	166	3134	4426	4794
CYTH1	-4310	6083	-3732	6593
CYTH2	-4152	2056	1606	2352
CYTH3	-4123	-751	-2636	-968
CYTH4	-2168	4026	3992	3823
DCTN2	-3591	-463	4022	-727
DCTN3	-2237	4070	2936	2751
DCTN4	3328	3748	3561	4416
DCTN5	-4299	7627	-377	6058
DCTN6	4349	6414	3502	6880
DENND1A	-3817	4485	3080	3969
DENND1B	1362	-208	-2212	7218
DENND1C	-913	4060	1427	3359
DENND2C	2085	7443	1698	875
DENND2D	-3006	6416	-4499	7010
DENND3	238	2864	4317	2137
DENND4A	2285	2488	-1231	2736
DENND4B	-2313	386	3550	1004
DENND5A	523	363	3831	1439
DENND6A	632	541	315	280
DNM1	2874	2154	2211	1607
DNM2	-4239	6583	3699	3063
DTNBP1	-2206	3858	-1281	284
DVL2	-4238	641	-2088	4883
DYNC1H1	-2872	1165	-441	4433
DYNC1I2	3141	258	2171	693
DYNC1LI1	3353	6061	2935	3242
DYNC1LI2	1369	3124	3014	-185
DYNLL1	-405	5371	1250	5150
DYNLL2	-3503	3295	-3679	-924
EPN1	-4028	6984	4265	5033
EPN2	-304	4214	-483	2946
EPS15	4441	4977	1513	-516
EPS15L1	-2993	7303	2688	2728
EXOC1	4399	2297	3773	6221
EXOC2	2004	4367	-2438	5976
EXOC3	-3160	2544	2698	3757
EXOC4	-1169	7042	1367	1729
EXOC5	3529	1661	-1153	6714
EXOC6	3705	6196	3426	2017
EXOC7	-4120	6263	3413	2374
EXOC8	121	4904	208	6706
FCHO1	-2622	5225	-98	6032
FCHO2	115	8080	2592	-593
FNBP1	167	1677	-695	2510
FTH1	-378	3718	2380	3117
FTL	609	3955	3972	-1424
GABARAP	-323	5861	2960	4039
GABARAPL2	58	2777	1514	2948
GAK	-1810	6922	3503	6663
GALNT2	-3638	-60	3954	-1747
GAPVD1	2376	3686	2209	5350
GBF1	-1062	3856	2349	4984
GCC1	-1655	-483	-978	-1633
GCC2	2093	1912	-2350	3257
GDI2	3001	7874	2004	3343
GGA1	-2180	2104	3959	4228
GGA2	198	5766	1352	4334
GGA3	-1147	1423	3637	671
GJD3	673	100	4213	-251
GNS	1404	5454	4533	4428
GOLGA1	1602	1857	3087	1794
GOLGA2	-2742	1710	3119	-1359
GOLGA4	3581	6203	-1638	775
GOLGA5	3856	5512	1831	-549
GOLGB1	1044	2451	-1747	5354
GOLIM4	-1130	8075	3684	2148
GORASP1	128	-448	4266	-281
GOSR1	-3956	5572	-2738	-852
GOSR2	2770	4634	1047	5878
GPS1	-4246	7866	-691	6188
GRB2	29	5972	4230	6239
HBEGF	-3771	8140	-172	-1006
HGS	-803	2229	3794	4350
HIP1	-484	4538	3755	6520
HIP1R	-1364	4626	-4030	-20
HPS1	-2614	-106	3281	804
HPS4	86	3749	-1770	4212
IGF2R	-4041	-23	3850	-1657
ITSN1	3406	5404	4232	3959
ITSN2	3775	4715	2265	-585
KDELR1	119	2641	3623	4934
KDELR2	2138	7300	1899	1832
KIAA0319	-312	5201	418	2703
KIF11	2296	7352	-1688	1895
KIF13B	-3457	2407	2260	2528
KIF15	1694	6303	-1340	6307
KIF16B	-3036	8250	-1324	5963
KIF18A	2515	2110	32	3290
KIF18B	1112	8242	1117	5530
KIF1B	2039	5842	3646	1220
KIF20A	627	-149	-591	1403
KIF20B	4196	4457	-3301	4533
KIF21A	3402	4292	-3746	-346
KIF21B	-2638	826	-209	2388
KIF22	-1338	3577	-4145	6181
KIF23	1258	2564	1959	805
KIF26B	-3504	5580	-2856	-1901
KIF27	2744	2123	97	6074
KIF2A	-2414	107	-3921	4006
KIF2C	3056	5593	433	-12
KIF3A	1773	3240	-4199	6172
KIF3B	765	1867	1704	2018
KIF3C	-3143	2102	1672	-1428
KIF5B	3638	7491	2378	4669
KIF6	3434	8065	2250	2531
KIF9	-3260	5238	1407	2418
KIFAP3	3661	5881	-2260	-68
KIFC1	357	1241	-1226	1767
KIFC2	-2011	6032	699	2527
KLC1	-2743	7465	2962	4385
KLC2	-1865	5384	-1364	1505
KLC4	-2811	2807	-494	4366
LDLR	1595	3917	3620	1548
LDLRAP1	-657	-663	-4665	4895
LMAN1	3906	722	-4216	5993
LMAN2	-2034	7197	3355	6264
LMAN2L	-3963	905	637	1715
LNPEP	1126	2921	-1545	2406
M6PR	1891	6902	-1109	5977
MADD	-2282	1840	1338	-1302
MAN1A1	-1909	4738	3847	1559
MAN1A2	283	4596	-2773	3421
MAN1C1	-2831	2191	-4559	145
MAN2A1	2237	3669	-1293	2421
MAN2A2	-2147	4751	3591	2485
MCFD2	-636	4042	254	2397
MIA3	3409	4173	-1653	4042
MON1A	-4403	6645	357	1152
MON1B	-1120	5175	3781	1931
MVB12A	-3996	7835	3677	357
MYH9	-3635	3380	2352	6144
MYO6	2392	7543	-3494	1793
NAA30	-91	6239	-4319	2646
NAA35	-133	8126	-3157	4713
NAA38	-4204	-400	3463	-541
NAPA	1052	6631	3158	3102
NAPB	4283	1054	1430	2662
NAPG	3494	7308	3293	2684
NBAS	1237	579	-422	3732
NECAP1	2663	5493	1532	3774
NECAP2	-2159	5528	-139	3097
NEDD8	-3865	5558	3129	-105
OPTN	1105	3550	-4314	-509
PACSIN1	-4696	6614	-4211	-1067
PACSIN2	1091	3892	3330	6929
PAFAH1B1	-363	5586	1470	6856
PAFAH1B2	2330	4486	909	2435
PAFAH1B3	-3673	2779	-1844	6669
PICALM	2035	2214	3735	-1231
PIP5K1C	-4599	8022	2668	3895
PLA2G6	-4368	2559	-2235	826
PLIN3	-2513	4565	4504	23
POLG	-4187	3041	-196	3652
PPP6C	4016	45	-488	6977
PPP6R1	-4502	4331	2949	-1033
PPP6R3	2435	5885	-105	-1717
PRKAB1	2967	3175	3402	-840
PRKAB2	942	4048	-1766	3091
PRKAG1	3046	1524	2735	-1054
PRKAG2	2660	5977	-522	1021
PUM1	144	4708	1708	6660
RAB10	2203	1022	4224	3067
RAB11A	2794	825	518	2440
RAB11B	-4659	2503	1414	3899
RAB12	3834	-628	-290	-468
RAB14	3720	1861	1150	-378
RAB18	4478	1161	1696	2764
RAB1A	3317	4326	3783	6417
RAB1B	-4180	2578	3559	4466
RAB27A	3269	7260	2952	222
RAB30	-1557	1955	-4202	2925
RAB33B	1192	5131	-499	5179
RAB35	-3904	5087	1883	905
RAB3A	-4569	3507	482	4347
RAB3GAP1	3929	4939	1012	3219
RAB3GAP2	3745	6026	1300	3837
RAB3IP	393	3951	-540	678
RAB43	-4537	157	1015	5467
RAB4A	272	2850	-1411	559
RAB5A	4303	1753	1458	3958
RAB5B	-516	1208	1896	1957
RAB5C	-2850	2984	3898	797
RAB6A	3034	6426	2839	3323
RAB7A	837	-522	3489	-124
RAB8A	1084	791	1534	1826
RAB8B	3632	7384	1844	1101
RABEP1	2002	-113	-1782	6119
RABEPK	-3595	5232	2099	5563
RABGAP1	2680	4978	1625	6383
RABGEF1	-2671	6082	1743	3772
RAC1	3574	7484	4225	5539
RACGAP1	3851	3065	2101	4089
RALA	2197	1756	-3637	2302
RALGAPA2	-1940	7363	3740	-284
RALGAPB	378	5716	-280	3710
REPS1	-2621	1877	1790	6312
RGP1	-4565	1570	1277	-1038
RHOBTB3	-4744	8281	-4193	1297
RHOQ	3301	-35	1950	-160
RIC1	-1766	3572	3168	6855
RIN1	179	1706	4570	-1286
RINL	-3847	5770	-2383	6129
RINT1	4241	7058	-4058	3453
RPS27A	-3731	2481	-4078	2589
SAR1B	4471	7978	1753	3060
SBF1	-3967	5806	-2669	3727
SCARB2	3480	2820	4099	3550
SCOC	4025	3499	-3869	2228
SEC13	-1298	7330	2552	6209
SEC16A	-2375	7854	2914	4811
SEC22A	2457	3215	-3204	2581
SEC22C	841	1561	-2109	5698
SEC23A	2416	6271	707	1833
SEC23IP	4089	5316	-771	1231
SEC24A	2469	2022	2595	4761
SEC24B	3316	7026	1710	-13
SEC24C	-1756	902	2641	-336
SEC24D	2700	6653	3967	1527
SEC31A	2995	5193	779	2523
SFN	-2816	-551	990	-1777
SH3GL1	-3765	6412	3499	6038
SNAP23	2642	7973	1694	-471
SNAP29	-4308	6060	3209	3148
SNAPIN	1440	1551	3226	1354
SNF8	-3646	7515	3159	5286
SNX18	-2778	1863	4219	-690
SNX2	1890	3977	3598	186
SPTAN1	-4171	369	-4508	-407
SPTBN1	-3552	7730	-4056	3657
SPTBN5	3170	2471	2062	2256
SRC	-1769	-92	-2399	-1474
STAM	1450	1971	-1016	6489
STAM2	4057	4699	1834	3301
STX10	-2971	1382	4198	5276
STX16	-1131	2042	738	1974
STX17	2526	1979	-3383	-218
STX18	-100	5758	2502	2718
STX4	-1332	4490	3053	1609
STX5	-2844	3219	3004	5924
STX6	-1451	3530	2035	-252
STXBP3	4513	5653	2586	199
SURF4	-2330	5219	1962	3679
SYNJ1	3931	7273	3923	2804
SYNJ2	-3841	2785	-4552	-505
SYS1	-1783	4496	-1300	4318
SYT11	462	4056	2651	4051
SYTL1	-2352	7138	-1027	-620
TBC1D1	-751	2020	3751	-1098
TBC1D10A	-3304	6390	-325	5670
TBC1D10B	-3270	7645	3801	6335
TBC1D10C	-4516	3143	-3275	6910
TBC1D13	-4006	5660	1520	4703
TBC1D14	-1244	2659	4030	30
TBC1D15	4405	1582	-2295	5332
TBC1D17	-2736	8072	-579	6197
TBC1D2	-3429	7323	4205	647
TBC1D20	-1052	2418	662	1409
TBC1D24	-971	6335	2150	4060
TBC1D4	319	-160	-4513	4592
TBC1D7	-513	7387	2047	5949
TFRC	3790	8109	1195	-131
TGFA	-2177	7641	3789	4631
TGOLN2	-1575	2330	3696	5917
TMED10	542	5270	-3068	3393
TMED2	3441	4473	377	5944
TMED3	-1376	8120	1480	5784
TMED7	2191	3348	-548	-959
TMED9	-4331	5690	3636	1623
TMEM115	-3345	1678	1526	-632
TMF1	4169	1459	-203	1642
TOR1A	-1612	5645	2824	5480
TOR1B	2849	156	2856	-606
TPD52	744	5284	-4530	5616
TRAPPC1	-1916	3999	3336	5232
TRAPPC10	-3693	375	177	6985
TRAPPC12	-2089	-369	3603	7027
TRAPPC13	4278	1564	954	7203
TRAPPC2L	142	3496	794	1131
TRAPPC3	-890	6763	2625	-470
TRAPPC4	1341	2746	-542	1676
TRAPPC5	-3587	7461	1777	29
TRAPPC6A	-3774	-805	-3674	-1704
TRAPPC6B	1975	7069	-190	1818
TRAPPC8	3547	8370	1882	59
TRAPPC9	-3167	1363	600	-816
TRIP11	2098	4627	-1197	5854
TSC1	-514	6027	1193	4695
TSC2	-3080	5070	1798	3951
TSG101	3637	1780	2134	-488
TXNDC5	2037	7500	-1760	-1871
UBA52	-3208	4386	-596	-69
UBAP1	-525	951	3509	5037
UBB	-2084	561	-996	5058
UBC	-1739	2624	1876	3220
UBQLN1	1256	4010	-273	2747
ULK1	-1834	6338	4469	1
USE1	-1875	2600	-1317	654
USO1	4325	3153	-48	3424
USP6NL	-25	4501	1518	5623
VAMP2	258	533	-3262	-1237
VAMP3	1811	2454	2982	619
VAMP4	3953	933	-8	1517
VAMP8	-2659	3376	1656	868
VPS25	-1568	1061	4029	-962
VPS28	-3812	6093	351	6113
VPS36	4158	282	-1641	1902
VPS37A	4163	7364	2173	3939
VPS37B	-4074	2182	2437	-1609
VPS37C	255	4234	4177	4035
VPS45	3921	5138	1722	3197
VPS4A	-4532	1740	-599	3112
VPS51	-4714	52	-3959	-1321
VPS52	-20	5288	2229	5048
VPS53	1557	6059	3111	4287
VPS54	2043	4841	625	-1402
VTA1	3993	6267	676	3950
VTI1A	-2214	5996	2894	3539
WASL	2751	7375	-567	4644
YKT6	-3493	-250	2413	3314
YWHAB	4207	4074	788	2152
YWHAE	2448	6182	3206	1288
YWHAG	-1658	5656	3774	1919
YWHAH	1174	3456	3029	-1274
YWHAQ	972	1310	-2670	3225
YWHAZ	3562	2726	-278	4293
ZW10	3450	4438	-1152	-591

---

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Vesicle-mediated transport

Vesicle-mediated transport

metric	value
setSize	442
pMANOVA	6.28e-14
p.adjustMANOVA	2.6e-12
s.dist	0.232
s.t0_crp_RNA	0.0152
s.t0_crp_meth	0.0408
s.pod_crp_RNA	0.227
s.pod_crp_meth	0.00407
p.t0_crp_RNA	0.589
p.t0_crp_meth	0.147
p.pod_crp_RNA	5.8e-16
p.pod_crp_meth	0.885

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	t0_crp_meth
ARF1	3973	8373
AP1B1	4242	7580
RAC1	4225	7484
TBC1D2	4205	7323
EPN1	4265	6984
GOLIM4	3684	8075
TBC1D10B	3801	7645
TGFA	3789	7641
MVB12A	3677	7835
CHMP2A	4090	6990
SYNJ1	3923	7273
ULK1	4469	6338
RALGAPA2	3740	7363
SEC24D	3967	6653
CLTCL1	3389	7763
GRB2	4230	5972
CBL	3285	7589
GNS	4533	5454
DNM2	3699	6583
GAK	3503	6922

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
AAK1	-307	5697	-3026	2550
ACBD3	957	2079	-263	201
ACTR10	2603	5113	1646	4867
ACTR1A	-1288	879	3846	1932
ACTR2	3144	4932	2747	3844
ACTR3	2753	4481	2482	5950
ADRB2	-1851	5254	-3071	2808
AGFG1	898	4305	3495	4594
AGPAT3	106	-470	3507	637
AKT1	-4471	4213	2297	1109
AKT2	-4622	3462	2041	5430
ALS2CL	-2421	4573	-4523	2557
ANK1	-2221	250	285	947
ANK3	-190	-846	-2640	1579
ANKRD27	-975	5992	811	2102
ANKRD28	-435	7479	-2531	548
AP1B1	-3672	7580	4242	5781
AP1G1	1620	6342	1504	2214
AP1G2	-780	2265	188	-226
AP1M1	-4217	2143	3873	1777
AP1S3	938	5055	686	1942
AP2A1	-2927	1888	4575	-316
AP2M1	-4018	5714	2737	3723
AP2S1	-1597	3981	3589	6037
AP3B1	657	2417	2046	3782
AP3S1	2086	8165	1215	6509
AP4B1	576	5745	490	1635
AP4E1	1459	4969	1100	1918
AP4M1	-245	-818	3840	6148
AP4S1	3958	5921	-779	6581
APP	-1029	7569	1303	6621
ARCN1	860	5980	657	-399
ARF1	-3573	8373	3973	-1819
ARF3	-2676	4360	3215	274
ARF4	3479	2557	3434	4619
ARF5	-2924	2625	3626	-939
ARF6	-1265	6257	-355	3741
ARFGAP1	-2602	2665	2283	6819
ARFGAP3	3528	7016	1360	724
ARFIP2	-1668	7489	-849	-113
ARFRP1	-3305	4052	-1900	6544
ARL1	4386	4709	-1381	2168
ARPC2	1775	5683	3457	2292
ARPC3	2785	4820	3580	3208
ARPC5	2109	2335	3836	2611
ARRB1	-3738	3174	2221	-1276
ARRB2	-2258	4618	4280	2913
ASPSCR1	-3829	6713	-148	5822
BET1	3509	2475	-2271	1788
BET1L	-1184	5185	-1408	4144
BICD1	771	3591	-1010	2613
BICD2	-4553	3563	3233	556
BIN1	-3206	-525	-3859	617
BLOC1S1	-3436	5018	4433	-817
BLOC1S3	-1098	3881	-961	6141
BLOC1S6	1619	1296	-635	4817
BNIP1	2859	6479	-2060	4079
C2CD5	4529	8413	-759	6925
CALM1	1287	3980	-2201	4501
CALR	1148	3542	1904	5712
CAPZA1	4166	7801	2992	999
CAPZA2	3798	3735	2976	4666
CAPZB	-747	3052	3210	-308
CBL	-1090	7589	3285	1012
CCZ1	1836	4385	3314	-1868
CD3D	799	-531	-4088	7271
CD4	-528	5984	-2076	909
CD55	1738	3285	4145	1455
CD59	-1703	4468	-1328	-1682
CENPE	4361	2608	751	-74
CHMP2A	-1768	6990	4090	5361
CHMP2B	4107	5724	-169	1684
CHMP3	1129	-59	2516	3694
CHMP4A	1969	1766	2505	4137
CHMP4B	-2750	4108	4089	5510
CHMP5	4239	1915	3667	4369
CHMP6	-4088	1554	2508	2702
CHMP7	-1133	6914	-4438	6062
CLINT1	1393	2370	437	-1927
CLTA	185	1469	2876	-546
CLTB	-3946	595	3085	-918
CLTC	461	2670	3511	7256
CLTCL1	-2388	7763	3389	4510
CNIH1	-1141	-831	-1304	6432
COG1	-60	-288	-2338	922
COG2	2417	4037	-1211	-1011
COG3	3473	939	-1582	755
COG4	4111	3504	3396	645
COG5	4286	409	272	2084
COG6	2817	5686	-2392	3686
COG7	4381	3387	4493	3161
COG8	-2327	5515	-557	2377
COPA	-345	1659	3754	5454
COPB1	4354	2889	2313	2637
COPB2	2955	6063	2519	3476
COPE	-4232	6600	3298	434
COPS2	4242	-444	-219	6454
COPS3	3525	4677	-321	1714
COPS4	1765	3598	-1111	5824
COPS5	3093	1002	1206	3236
COPS6	-2086	3313	353	782
COPS7A	-2164	503	3256	-66
COPS7B	155	6760	95	5098
COPS8	3726	5525	-3738	-1150
COPZ1	1494	1151	1143	97
COPZ2	-2278	3415	-2800	-1670
CPD	-503	2484	3795	-1838
CSNK1D	-4441	6564	2787	3046
CTSC	2238	2310	3599	1311
CTSZ	-1191	-74	4162	-1978
CUX1	166	3134	4426	4794
CYTH1	-4310	6083	-3732	6593
CYTH2	-4152	2056	1606	2352
CYTH3	-4123	-751	-2636	-968
CYTH4	-2168	4026	3992	3823
DCTN2	-3591	-463	4022	-727
DCTN3	-2237	4070	2936	2751
DCTN4	3328	3748	3561	4416
DCTN5	-4299	7627	-377	6058
DCTN6	4349	6414	3502	6880
DENND1A	-3817	4485	3080	3969
DENND1B	1362	-208	-2212	7218
DENND1C	-913	4060	1427	3359
DENND2C	2085	7443	1698	875
DENND2D	-3006	6416	-4499	7010
DENND3	238	2864	4317	2137
DENND4A	2285	2488	-1231	2736
DENND4B	-2313	386	3550	1004
DENND5A	523	363	3831	1439
DENND6A	632	541	315	280
DNM1	2874	2154	2211	1607
DNM2	-4239	6583	3699	3063
DTNBP1	-2206	3858	-1281	284
DVL2	-4238	641	-2088	4883
DYNC1H1	-2872	1165	-441	4433
DYNC1I2	3141	258	2171	693
DYNC1LI1	3353	6061	2935	3242
DYNC1LI2	1369	3124	3014	-185
DYNLL1	-405	5371	1250	5150
DYNLL2	-3503	3295	-3679	-924
EPN1	-4028	6984	4265	5033
EPN2	-304	4214	-483	2946
EPS15	4441	4977	1513	-516
EPS15L1	-2993	7303	2688	2728
EXOC1	4399	2297	3773	6221
EXOC2	2004	4367	-2438	5976
EXOC3	-3160	2544	2698	3757
EXOC4	-1169	7042	1367	1729
EXOC5	3529	1661	-1153	6714
EXOC6	3705	6196	3426	2017
EXOC7	-4120	6263	3413	2374
EXOC8	121	4904	208	6706
FCHO1	-2622	5225	-98	6032
FCHO2	115	8080	2592	-593
FNBP1	167	1677	-695	2510
FTH1	-378	3718	2380	3117
FTL	609	3955	3972	-1424
GABARAP	-323	5861	2960	4039
GABARAPL2	58	2777	1514	2948
GAK	-1810	6922	3503	6663
GALNT2	-3638	-60	3954	-1747
GAPVD1	2376	3686	2209	5350
GBF1	-1062	3856	2349	4984
GCC1	-1655	-483	-978	-1633
GCC2	2093	1912	-2350	3257
GDI2	3001	7874	2004	3343
GGA1	-2180	2104	3959	4228
GGA2	198	5766	1352	4334
GGA3	-1147	1423	3637	671
GJD3	673	100	4213	-251
GNS	1404	5454	4533	4428
GOLGA1	1602	1857	3087	1794
GOLGA2	-2742	1710	3119	-1359
GOLGA4	3581	6203	-1638	775
GOLGA5	3856	5512	1831	-549
GOLGB1	1044	2451	-1747	5354
GOLIM4	-1130	8075	3684	2148
GORASP1	128	-448	4266	-281
GOSR1	-3956	5572	-2738	-852
GOSR2	2770	4634	1047	5878
GPS1	-4246	7866	-691	6188
GRB2	29	5972	4230	6239
HBEGF	-3771	8140	-172	-1006
HGS	-803	2229	3794	4350
HIP1	-484	4538	3755	6520
HIP1R	-1364	4626	-4030	-20
HPS1	-2614	-106	3281	804
HPS4	86	3749	-1770	4212
HSP90AA1	3100	4857	-2176	6208
HSP90B1	4301	7702	-1893	2127
HSPH1	2728	3874	-3388	5506
HYOU1	-2186	7044	-642	3849
IGF2R	-4041	-23	3850	-1657
ITSN1	3406	5404	4232	3959
ITSN2	3775	4715	2265	-585
KDELR1	119	2641	3623	4934
KDELR2	2138	7300	1899	1832
KIAA0319	-312	5201	418	2703
KIF11	2296	7352	-1688	1895
KIF13B	-3457	2407	2260	2528
KIF15	1694	6303	-1340	6307
KIF16B	-3036	8250	-1324	5963
KIF18A	2515	2110	32	3290
KIF18B	1112	8242	1117	5530
KIF1B	2039	5842	3646	1220
KIF20A	627	-149	-591	1403
KIF20B	4196	4457	-3301	4533
KIF21A	3402	4292	-3746	-346
KIF21B	-2638	826	-209	2388
KIF22	-1338	3577	-4145	6181
KIF23	1258	2564	1959	805
KIF26B	-3504	5580	-2856	-1901
KIF27	2744	2123	97	6074
KIF2A	-2414	107	-3921	4006
KIF2C	3056	5593	433	-12
KIF3A	1773	3240	-4199	6172
KIF3B	765	1867	1704	2018
KIF3C	-3143	2102	1672	-1428
KIF5B	3638	7491	2378	4669
KIF6	3434	8065	2250	2531
KIF9	-3260	5238	1407	2418
KIFAP3	3661	5881	-2260	-68
KIFC1	357	1241	-1226	1767
KIFC2	-2011	6032	699	2527
KLC1	-2743	7465	2962	4385
KLC2	-1865	5384	-1364	1505
KLC4	-2811	2807	-494	4366
LDLR	1595	3917	3620	1548
LDLRAP1	-657	-663	-4665	4895
LMAN1	3906	722	-4216	5993
LMAN2	-2034	7197	3355	6264
LMAN2L	-3963	905	637	1715
LNPEP	1126	2921	-1545	2406
M6PR	1891	6902	-1109	5977
MADD	-2282	1840	1338	-1302
MAN1A1	-1909	4738	3847	1559
MAN1A2	283	4596	-2773	3421
MAN1C1	-2831	2191	-4559	145
MAN2A1	2237	3669	-1293	2421
MAN2A2	-2147	4751	3591	2485
MCFD2	-636	4042	254	2397
MIA3	3409	4173	-1653	4042
MON1A	-4403	6645	357	1152
MON1B	-1120	5175	3781	1931
MVB12A	-3996	7835	3677	357
MYH9	-3635	3380	2352	6144
MYO6	2392	7543	-3494	1793
NAA30	-91	6239	-4319	2646
NAA35	-133	8126	-3157	4713
NAA38	-4204	-400	3463	-541
NAPA	1052	6631	3158	3102
NAPB	4283	1054	1430	2662
NAPG	3494	7308	3293	2684
NBAS	1237	579	-422	3732
NECAP1	2663	5493	1532	3774
NECAP2	-2159	5528	-139	3097
NEDD8	-3865	5558	3129	-105
OPTN	1105	3550	-4314	-509
PACSIN1	-4696	6614	-4211	-1067
PACSIN2	1091	3892	3330	6929
PAFAH1B1	-363	5586	1470	6856
PAFAH1B2	2330	4486	909	2435
PAFAH1B3	-3673	2779	-1844	6669
PICALM	2035	2214	3735	-1231
PIP5K1C	-4599	8022	2668	3895
PLA2G6	-4368	2559	-2235	826
PLIN3	-2513	4565	4504	23
POLG	-4187	3041	-196	3652
PPP6C	4016	45	-488	6977
PPP6R1	-4502	4331	2949	-1033
PPP6R3	2435	5885	-105	-1717
PRKAB1	2967	3175	3402	-840
PRKAB2	942	4048	-1766	3091
PRKAG1	3046	1524	2735	-1054
PRKAG2	2660	5977	-522	1021
PUM1	144	4708	1708	6660
RAB10	2203	1022	4224	3067
RAB11A	2794	825	518	2440
RAB11B	-4659	2503	1414	3899
RAB12	3834	-628	-290	-468
RAB14	3720	1861	1150	-378
RAB18	4478	1161	1696	2764
RAB1A	3317	4326	3783	6417
RAB1B	-4180	2578	3559	4466
RAB27A	3269	7260	2952	222
RAB30	-1557	1955	-4202	2925
RAB33B	1192	5131	-499	5179
RAB35	-3904	5087	1883	905
RAB3A	-4569	3507	482	4347
RAB3GAP1	3929	4939	1012	3219
RAB3GAP2	3745	6026	1300	3837
RAB3IP	393	3951	-540	678
RAB43	-4537	157	1015	5467
RAB4A	272	2850	-1411	559
RAB5A	4303	1753	1458	3958
RAB5B	-516	1208	1896	1957
RAB5C	-2850	2984	3898	797
RAB6A	3034	6426	2839	3323
RAB7A	837	-522	3489	-124
RAB8A	1084	791	1534	1826
RAB8B	3632	7384	1844	1101
RABEP1	2002	-113	-1782	6119
RABEPK	-3595	5232	2099	5563
RABGAP1	2680	4978	1625	6383
RABGEF1	-2671	6082	1743	3772
RAC1	3574	7484	4225	5539
RACGAP1	3851	3065	2101	4089
RALA	2197	1756	-3637	2302
RALGAPA2	-1940	7363	3740	-284
RALGAPB	378	5716	-280	3710
REPS1	-2621	1877	1790	6312
RGP1	-4565	1570	1277	-1038
RHOBTB3	-4744	8281	-4193	1297
RHOQ	3301	-35	1950	-160
RIC1	-1766	3572	3168	6855
RIN1	179	1706	4570	-1286
RINL	-3847	5770	-2383	6129
RINT1	4241	7058	-4058	3453
RPS27A	-3731	2481	-4078	2589
SAR1B	4471	7978	1753	3060
SBF1	-3967	5806	-2669	3727
SCARB1	-4504	294	-71	4836
SCARB2	3480	2820	4099	3550
SCOC	4025	3499	-3869	2228
SEC13	-1298	7330	2552	6209
SEC16A	-2375	7854	2914	4811
SEC22A	2457	3215	-3204	2581
SEC22C	841	1561	-2109	5698
SEC23A	2416	6271	707	1833
SEC23IP	4089	5316	-771	1231
SEC24A	2469	2022	2595	4761
SEC24B	3316	7026	1710	-13
SEC24C	-1756	902	2641	-336
SEC24D	2700	6653	3967	1527
SEC31A	2995	5193	779	2523
SFN	-2816	-551	990	-1777
SH3GL1	-3765	6412	3499	6038
SNAP23	2642	7973	1694	-471
SNAP29	-4308	6060	3209	3148
SNAPIN	1440	1551	3226	1354
SNF8	-3646	7515	3159	5286
SNX18	-2778	1863	4219	-690
SNX2	1890	3977	3598	186
SPTAN1	-4171	369	-4508	-407
SPTBN1	-3552	7730	-4056	3657
SPTBN5	3170	2471	2062	2256
SRC	-1769	-92	-2399	-1474
STAM	1450	1971	-1016	6489
STAM2	4057	4699	1834	3301
STX10	-2971	1382	4198	5276
STX16	-1131	2042	738	1974
STX17	2526	1979	-3383	-218
STX18	-100	5758	2502	2718
STX4	-1332	4490	3053	1609
STX5	-2844	3219	3004	5924
STX6	-1451	3530	2035	-252
STXBP3	4513	5653	2586	199
SURF4	-2330	5219	1962	3679
SYNJ1	3931	7273	3923	2804
SYNJ2	-3841	2785	-4552	-505
SYS1	-1783	4496	-1300	4318
SYT11	462	4056	2651	4051
SYTL1	-2352	7138	-1027	-620
TBC1D1	-751	2020	3751	-1098
TBC1D10A	-3304	6390	-325	5670
TBC1D10B	-3270	7645	3801	6335
TBC1D10C	-4516	3143	-3275	6910
TBC1D13	-4006	5660	1520	4703
TBC1D14	-1244	2659	4030	30
TBC1D15	4405	1582	-2295	5332
TBC1D17	-2736	8072	-579	6197
TBC1D2	-3429	7323	4205	647
TBC1D20	-1052	2418	662	1409
TBC1D24	-971	6335	2150	4060
TBC1D4	319	-160	-4513	4592
TBC1D7	-513	7387	2047	5949
TFRC	3790	8109	1195	-131
TGFA	-2177	7641	3789	4631
TGOLN2	-1575	2330	3696	5917
TMED10	542	5270	-3068	3393
TMED2	3441	4473	377	5944
TMED3	-1376	8120	1480	5784
TMED7	2191	3348	-548	-959
TMED9	-4331	5690	3636	1623
TMEM115	-3345	1678	1526	-632
TMF1	4169	1459	-203	1642
TOR1A	-1612	5645	2824	5480
TOR1B	2849	156	2856	-606
TPD52	744	5284	-4530	5616
TRAPPC1	-1916	3999	3336	5232
TRAPPC10	-3693	375	177	6985
TRAPPC12	-2089	-369	3603	7027
TRAPPC13	4278	1564	954	7203
TRAPPC2L	142	3496	794	1131
TRAPPC3	-890	6763	2625	-470
TRAPPC4	1341	2746	-542	1676
TRAPPC5	-3587	7461	1777	29
TRAPPC6A	-3774	-805	-3674	-1704
TRAPPC6B	1975	7069	-190	1818
TRAPPC8	3547	8370	1882	59
TRAPPC9	-3167	1363	600	-816
TRIP11	2098	4627	-1197	5854
TSC1	-514	6027	1193	4695
TSC2	-3080	5070	1798	3951
TSG101	3637	1780	2134	-488
TXNDC5	2037	7500	-1760	-1871
UBA52	-3208	4386	-596	-69
UBAP1	-525	951	3509	5037
UBB	-2084	561	-996	5058
UBC	-1739	2624	1876	3220
UBQLN1	1256	4010	-273	2747
ULK1	-1834	6338	4469	1
USE1	-1875	2600	-1317	654
USO1	4325	3153	-48	3424
USP6NL	-25	4501	1518	5623
VAMP2	258	533	-3262	-1237
VAMP3	1811	2454	2982	619
VAMP4	3953	933	-8	1517
VAMP8	-2659	3376	1656	868
VPS25	-1568	1061	4029	-962
VPS28	-3812	6093	351	6113
VPS36	4158	282	-1641	1902
VPS37A	4163	7364	2173	3939
VPS37B	-4074	2182	2437	-1609
VPS37C	255	4234	4177	4035
VPS45	3921	5138	1722	3197
VPS4A	-4532	1740	-599	3112
VPS51	-4714	52	-3959	-1321
VPS52	-20	5288	2229	5048
VPS53	1557	6059	3111	4287
VPS54	2043	4841	625	-1402
VTA1	3993	6267	676	3950
VTI1A	-2214	5996	2894	3539
WASL	2751	7375	-567	4644
YKT6	-3493	-250	2413	3314
YWHAB	4207	4074	788	2152
YWHAE	2448	6182	3206	1288
YWHAG	-1658	5656	3774	1919
YWHAH	1174	3456	3029	-1274
YWHAQ	972	1310	-2670	3225
YWHAZ	3562	2726	-278	4293
ZW10	3450	4438	-1152	-591

---

---

Gene expression (Transcription)

Gene expression (Transcription)

metric	value
setSize	1002
pMANOVA	7.09e-14
p.adjustMANOVA	2.84e-12
s.dist	0.163
s.t0_crp_RNA	0.0681
s.t0_crp_meth	0.0249
s.pod_crp_RNA	-0.123
s.pod_crp_meth	0.0788
p.t0_crp_RNA	0.000423
p.t0_crp_meth	0.198
p.pod_crp_RNA	1.83e-10
p.pod_crp_meth	4.43e-05

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	pod_crp_RNA	pod_crp_meth
NFATC2	-4600	7156
TCF7	-4677	6949
NUP88	-4454	7082
RORA	-4542	6931
RGCC	-4221	7229
NDC1	-4667	6480
FBXO32	-4547	6486
RPA1	-4589	6280
ZNF517	-4146	6890
GATA3	-4535	6272
RUNX3	-4197	6758
BRD1	-3892	7209
ZNF681	-4264	6565
EPC1	-4094	6720
WRN	-4272	6294
CNOT6L	-4280	6260
GTF3C4	-3671	7161
NR1D1	-4400	5905
NUP107	-4115	6299
ZNF530	-4546	5648

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
AAAS	-638	2718	243	1467
ABL1	-3241	5957	1585	2469
ACTB	-373	4248	4005	5446
ACTL6A	1992	1192	-2241	-311
AEBP2	-75	8010	-3439	6372
AFF4	5	5808	338	-209
AGO1	-3758	-794	3460	7137
AGO2	-2786	553	1558	7193
AGO3	4341	8301	1027	3465
AKT1	-4471	4213	2297	1109
AKT2	-4622	3462	2041	5430
ALYREF	-2943	3402	-1458	6735
ANAPC1	-1080	3338	-4436	2990
ANAPC10	2049	-304	48	-1324
ANAPC11	-4132	7036	1733	3188
ANAPC15	-3426	2681	3788	6481
ANAPC16	182	6850	-3231	6727
ANAPC2	-4276	1380	-883	2865
ANAPC4	4253	1488	341	-687
ANAPC5	1471	3129	-1620	5212
ANAPC7	4117	862	1103	1873
ANG	-1154	5340	3473	6524
APAF1	1473	7512	2266	-809
ARID1A	-2507	8410	3150	1914
ARID1B	-3430	5734	-35	4017
ARID2	965	-62	2	1091
ARID3A	-1696	3779	3531	2011
ARID4B	3774	870	-772	2402
ASH2L	2764	5752	2617	3075
ATAD2	3820	-523	-2320	142
ATM	-310	2433	-3404	3035
ATR	1824	3464	-1138	930
ATRIP	861	7909	-632	1869
ATXN3	2756	2315	-124	2715
AURKA	4033	3126	1282	4012
AURKB	-572	6976	300	5273
AUTS2	-1625	5778	-4118	-1351
AXIN1	-4500	6775	-2630	-858
BANP	346	1173	1643	195
BARD1	3324	7135	-228	5970
BAX	-2161	-40	3408	1161
BAZ1B	162	5221	-1116	1271
BAZ2A	158	3823	2898	3649
BBC3	-3984	3819	-944	5285
BCDIN3D	1157	2729	31	3632
BCL2L11	72	5304	2972	5662
BCL6	-1059	973	4510	3669
BDP1	1796	7164	-1404	6071
BID	850	4220	3263	5465
BIRC5	2315	6240	-142	1965
BLM	1546	3904	-1869	5262
BMI1	2216	4611	-4071	-805
BNIP3L	2463	2954	221	4411
BRCA1	2996	936	1989	1586
BRD1	-3096	7497	-3892	7209
BRD2	-1041	3425	-1073	5080
BRD7	4347	3491	-332	3924
BRF1	-4657	3879	942	2464
BRF2	-3530	7168	-2123	2460
BRIP1	2506	5472	-2765	63
BRPF1	-3859	712	-602	5933
BRPF3	-2382	4755	-1904	3308
BTG1	756	1205	-3022	5952
BTG2	-4426	4597	-3678	5260
CALM1	1287	3980	-2201	4501
CAMK2D	-1499	3793	-4469	-529
CAMK2G	943	31	471	6716
CAMK4	-2175	2725	-4662	2759
CASC3	-2211	3328	2647	5105
CASP1	4199	-379	2331	7029
CASP10	2029	1610	1690	-1805
CASP6	2430	1174	-3356	-556
CAT	282	-220	3549	-1204
CAV1	244	7711	-1532	4591
CBFB	2554	1466	-1295	5860
CBX3	4079	990	1383	2289
CBX4	-4353	5597	1835	278
CBX6	-4118	7513	1317	3612
CBX8	-1680	73	957	4610
CCNA2	1858	6897	-718	4427
CCNB1	2224	896	-1031	1332
CCNC	4378	2184	-3183	4187
CCND1	-2434	3555	-1529	1006
CCND2	256	-613	-4359	-1565
CCND3	-3773	2902	3568	4155
CCNE1	2776	6732	-1140	5954
CCNE2	578	5056	1456	5657
CCNG1	2834	594	-3895	857
CCNG2	1857	3589	3009	2810
CCNH	4319	5970	2670	1260
CCNK	1908	2111	1995	6591
CCNT1	-1408	208	-2477	1761
CDC16	1700	7029	-672	3340
CDC23	3736	4379	-3706	1597
CDC40	3487	3340	1326	7122
CDC7	1314	1903	314	6397
CDC73	3220	2286	623	5717
CDK1	3365	4275	-2423	1888
CDK12	-911	1539	964	5159
CDK13	-2241	5468	9	5777
CDK2	872	6555	-1520	2965
CDK4	-2472	6677	-3970	4918
CDK5	-142	4633	4463	3491
CDK5R1	-2189	7694	-1862	7121
CDK6	1583	2087	-1961	562
CDK7	3836	3659	1886	4034
CDK8	2364	2319	1443	5793
CDK9	-4663	6640	1582	3144
CDKN1A	1249	7552	1225	2427
CDKN1B	-532	1651	-3401	3367
CDKN2A	1419	4859	1760	3478
CEBPB	225	2576	4283	337
CENPJ	1728	1969	-3082	4073
CHD3	-3994	1460	-3143	6048
CHD4	-1845	1886	-1491	640
CHEK1	2868	3127	-2668	51
CHEK2	2096	2247	1066	5330
CITED2	-2247	6642	3127	1266
CITED4	-2323	1825	-330	-93
CLP1	-616	2944	1426	2378
CNOT1	-24	2748	-442	4958
CNOT10	1906	1981	-852	3018
CNOT11	2653	2636	493	3729
CNOT3	-2438	3446	3132	3093
CNOT4	4218	2243	-1242	5999
CNOT6	3521	6031	1641	4652
CNOT6L	-926	4317	-4280	6260
CNOT7	4102	6482	-4009	-58
CNOT8	2112	5181	-110	5796
COX11	876	3013	-3870	2566
COX14	-3546	3840	-639	6532
COX16	4295	3547	-2592	1183
COX19	2866	295	-1139	47
COX20	3094	3484	-2758	4916
COX4I1	-1263	4517	758	6760
COX5A	-2294	3384	1557	-152
COX5B	-2301	-243	2885	-52
COX6A1	-3643	1802	2548	3077
COX6B1	-824	2348	3631	564
COX6C	-566	2398	-1210	2304
COX7A2L	1864	5783	511	5083
COX7C	-2628	598	-850	1883
COX8A	-3750	3933	3513	2226
CPSF1	-1060	6585	1861	1083
CPSF2	3577	2290	1770	988
CPSF3	2898	-399	2488	5336
CPSF4	-3531	7169	-943	1770
CRADD	457	1876	530	1024
CRCP	998	6155	1033	4707
CREB1	2387	5046	-1542	1422
CREBBP	-4011	6807	2122	892
CSNK2A2	769	3941	1687	5734
CSNK2B	63	7476	2450	4742
CSTF1	4	6872	-3334	6207
CTDP1	-4552	1491	2692	1002
CTLA4	-1839	-754	-2871	7088
CTNNB1	2009	6708	3025	5069
CTR9	2334	683	-875	-440
CTSL	873	8363	4377	3028
CTSV	-308	7141	-258	5169
CUL1	4355	1572	-4161	-1190
CYCS	2686	2440	-1957	5368
DAXX	-201	3518	-1501	1574
DDB2	3192	-153	1979	-1221
DDIT3	1121	1634	1381	5191
DDIT4	-4212	1788	-282	3702
DDX21	2972	7462	-1540	3312
DEK	4265	4871	-866	6180
DGCR8	-3213	7012	-3145	6996
DICER1	1685	8176	3956	6635
DNA2	3717	1475	-1669	1296
DNMT1	-3915	3729	-4332	4752
DNMT3A	-3887	1525	-2019	-1251
DNMT3B	-4512	8014	1287	3249
DPY30	2938	5242	735	1423
DYRK2	-3137	3873	-4607	4996
E2F1	1142	1123	-46	3145
E2F4	-2545	833	2056	1015
E2F5	1122	2517	-2283	4180
E2F6	1496	5798	-3472	4027
E2F7	2439	6513	-3001	3875
E2F8	1918	3140	-781	149
EAF1	-868	426	1086	-327
EED	3842	2920	-2433	3088
EHMT1	-3787	-502	1398	2699
EHMT2	-4387	5086	-526	3889
EIF4A3	-2476	5309	-384	4597
ELAC2	-936	5459	-1517	275
ELF1	3114	3221	-1512	-1465
ELF2	3431	4623	2613	978
ELL	-3712	2298	1994	1501
ELL2	3636	4419	443	167
ELL3	3405	3561	3442	2028
EP300	-1082	3351	3310	4900
EPC1	-1764	880	-4094	6720
ERBB2	-3822	7865	-4098	4159
ERCC2	-2656	1778	3047	1849
ERCC3	223	3545	2049	1487
ERCC6	-3418	6486	-3031	2399
ESR2	750	1948	-3155	4783
ESRRA	-3861	5908	4164	5420
EXO1	904	4012	-1808	4437
EZH2	4420	4467	549	2695
FANCC	-1548	6161	271	1401
FANCD2	-472	8018	-4122	4785
FANCI	3098	2269	-3153	1261
FAS	3890	-122	486	825
FBXO32	-2830	6776	-4547	6486
FBXW7	1395	6293	-812	6665
FIP1L1	858	2985	-1642	3099
FKBP5	-67	1860	4144	-681
FOS	-4562	4067	-1568	5645
FOXO1	-3602	816	-4632	3034
FOXO3	-3051	7309	2545	5022
FYTTD1	2371	4178	-3394	5126
FZR1	-3205	7403	689	2326
GADD45A	1544	65	3993	2249
GATA3	-395	8146	-4535	6272
GATAD2A	-3627	7010	578	189
GATAD2B	628	7335	806	5593
GLS	3225	569	-4643	2305
GPAM	667	3270	-3712	81
GPI	-2280	6574	1799	5672
GPS2	-1070	1235	1038	6828
GSK3B	-92	3624	973	4907
GSR	-680	1983	4161	4125
GTF2A1	2577	3931	-1896	1479
GTF2A2	2545	4271	652	286
GTF2B	3847	1770	1252	-1152
GTF2E2	3943	2516	2514	4884
GTF2F1	-4236	1342	2079	558
GTF2F2	2000	4258	2006	5306
GTF2H3	1068	8239	-3652	5703
GTF2H4	-995	6151	892	5239
GTF2H5	1838	1881	-279	3417
GTF3A	1251	513	-3846	2860
GTF3C1	-3371	4944	727	4215
GTF3C2	-2702	5927	-1298	2569
GTF3C3	3300	5761	-126	75
GTF3C4	195	8361	-3671	7161
GTF3C5	-3226	5276	343	3843
GTF3C6	3580	1124	1229	3594
HDAC1	1651	4891	908	3287
HDAC10	-2989	6333	2136	4923
HDAC11	-640	7740	1067	6082
HDAC2	2465	4575	-3268	5862
HDAC3	-1179	8278	2800	7113
HDAC4	-3577	1775	4019	887
HDAC5	-3319	622	1361	3068
HDAC7	-1539	3799	2058	-487
HENMT1	-140	4162	-2797	5054
HIPK1	-1578	1965	1986	4885
HIPK2	-3977	5390	3007	7090
HIVEP3	847	4979	1419	6936
HSP90AA1	3100	4857	-2176	6208
HSPD1	2363	1249	-4506	3524
HUS1	3362	3317	900	329
ICE2	4235	723	-3421	5836
IL2RA	1014	432	-3039	6866
ING2	-1354	-145	-186	1059
ING5	-2878	5986	-4191	4789
INTS1	-3636	26	2075	-478
INTS10	2825	2142	-50	16
INTS12	4306	3900	1463	3211
INTS2	2997	852	379	-1193
INTS3	1665	3869	4212	4013
INTS4	3390	2099	-1252	5757
INTS5	-3791	6794	-3405	4247
INTS6	3115	1433	-221	1940
INTS7	3977	1924	453	4769
INTS8	2973	6737	1497	4190
INTS9	-4278	2259	162	200
IPO8	2662	3733	1481	3771
ITCH	421	6841	732	4853
ITGA4	1894	4646	-3651	-394
ITGA5	-3223	6903	3878	3467
ITGAL	-1994	4404	1129	7036
IWS1	4161	6745	2975	3898
JARID2	-1546	5866	2980	-106
JMY	-1292	6969	-3967	5162
JUN	-3724	2763	-598	1283
JUNB	-4339	4464	541	5017
KAT2A	-1815	2972	-3604	1343
KAT2B	3395	625	-758	4028
KAT5	-124	5587	824	1952
KCTD1	-2071	5524	2218	2461
KCTD6	2713	7603	2328	-621
KMT2A	-1160	-498	-3075	7241
KMT2C	572	8418	1849	6982
KMT2D	-2949	-324	3024	6493
KMT2E	3346	-594	-482	7064
KRAS	4442	4004	1217	3139
L3MBTL2	-3523	6541	-3038	2967
LAMTOR1	-4534	-643	3758	-1587
LAMTOR2	-3989	-286	3497	-1340
LAMTOR3	3368	6744	792	957
LAMTOR4	-3934	1904	2799	6998
LAMTOR5	-1370	7060	2866	-881
LBR	1834	84	2040	2128
LDB1	-3986	4788	-1318	1166
LEO1	4519	5072	-36	4251
LMO2	1074	6049	4108	2867
LRPPRC	1641	373	-4505	1082
LSM10	-587	4321	2838	1062
LSM11	-3574	2770	-4485	-211
MAF	-66	3331	-2534	403
MAML1	-1765	5619	2743	1442
MAML2	-4166	2210	-3302	4626
MAML3	-2499	8118	4036	3460
MAP2K6	3151	2164	3939	4791
MAPK1	-745	2758	4197	6097
MAPK14	1563	2227	4024	2465
MAPK3	-4620	-475	3649	1978
MAPKAP1	1208	5508	898	5906
MAX	320	5513	-1889	1615
MBD2	3457	2853	2432	-303
MBD3	-4266	7251	-2567	6238
MDC1	-2165	3857	-3116	4409
MDM2	4264	1085	2091	2095
MDM4	2679	1108	500	5727
MEAF6	2466	7059	-3516	3083
MED1	-958	5969	-1763	4472
MED10	-634	434	-3398	2697
MED13	-27	6634	-1506	6578
MED15	-1967	632	150	5801
MED16	-1417	6758	775	-884
MED17	2502	1171	-2481	3538
MED20	334	3800	2922	180
MED23	2395	2524	160	3755
MED24	-3004	4336	1028	5182
MED25	-1368	5836	3323	565
MED26	-4409	4968	962	3021
MED27	-1097	2235	-20	1874
MED30	-1702	1813	-2527	4135
MED31	4462	8011	-815	2499
MED4	3667	1149	-134	127
MED6	4430	6997	-3117	6743
MED7	4299	448	-229	4940
MED8	3318	5166	3046	1234
MEN1	-3770	2124	-1576	1903
MGA	-90	1257	-2790	-909
MLLT1	-4489	6981	3458	4011
MLLT3	1200	4875	-4468	1331
MLST8	-2723	3408	89	2258
MNAT1	2008	2598	-2465	1516
MOV10	2762	7613	-818	-1880
MSH2	4144	7007	-3350	5925
MTA2	-1792	2504	585	5577
MTA3	-1256	851	-3154	5161
MTERF1	3922	8205	-1738	5744
MTF2	4518	2494	-2614	3354
MTOR	-3867	1233	454	3900
MYB	1716	530	-1100	-449
MYBBP1A	-3605	1993	-4411	5090
MYBL1	269	6137	-3504	3880
NABP1	4090	5420	4051	6495
NABP2	-2135	3866	2360	-1672
NBN	3992	1976	274	4477
NCBP1	4110	6523	-472	5857
NCBP2	4266	3714	-3787	4776
NCOR1	935	1094	2216	-530
NCOR2	-4337	576	4446	-1607
NDC1	-28	-272	-4667	6480
NDRG1	710	8091	3115	1648
NDUFA4	-903	2011	2325	4278
NEDD4L	-2331	220	3504	-1079
NELFA	-2112	6866	-245	3055
NELFB	-4505	5452	197	-649
NELFCD	-1931	4143	504	6414
NELFE	-840	8416	3052	1529
NFATC2	-2966	5180	-4600	7156
NFE2	373	3939	4293	-1802
NFIA	3688	3061	2790	264
NFIC	-1357	-517	4175	-1028
NFIX	-3272	2380	-1332	424
NFYA	-229	2632	244	102
NFYB	2887	7845	-4590	1588
NFYC	1959	3116	4374	226
NOP2	-3532	5036	-2782	6401
NOTCH1	-3689	2419	2614	6289
NOTCH4	-1388	3909	4488	4961
NR1D1	-4546	4990	-4400	5905
NR1D2	-1228	5196	-4418	520
NR1H2	-4065	7065	3532	6461
NR1H3	-2064	8041	2064	6204
NR2C1	3864	4112	-2460	4893
NR2C2	-3451	-70	-1672	7003
NR2C2AP	1120	3125	-3409	3955
NR3C1	94	4233	-1678	3509
NR3C2	-2004	6610	-4641	5082
NR4A1	798	3379	-1261	1085
NR4A2	-4746	6861	-2021	3570
NR4A3	-1608	3343	-1594	1460
NR6A1	-2788	-321	3166	-1394
NRBP1	-4138	5879	2225	5630
NUDT21	2631	5030	-4023	4270
NUP107	2943	1017	-4115	6299
NUP133	2030	1473	-2474	935
NUP153	1372	7264	-1870	4343
NUP155	1163	5083	-3460	3043
NUP160	1232	5781	-4066	1293
NUP188	-2474	591	-3287	2922
NUP205	1308	370	-3162	1670
NUP210	-4099	775	-1841	690
NUP214	779	7322	3866	4368
NUP35	3287	7567	-4566	-557
NUP37	1488	500	-594	3398
NUP43	3972	139	-3557	6344
NUP50	2599	5772	-517	6704
NUP54	4432	6517	-2306	831
NUP62	-1277	2703	156	4608
NUP85	2428	5395	-713	4517
NUP88	1692	6430	-4454	7082
NUP93	1140	7850	-1307	2006
NUP98	808	1649	64	-747
PABPN1	-2016	7253	994	3061
PAF1	-2579	8149	1663	7078
PAPOLA	3033	3883	812	4316
PARP1	-2044	374	-4291	3582
PBRM1	1570	8093	984	3867
PCBP4	-787	7891	-3200	6282
PCGF5	3286	7880	-4252	1347
PCGF6	2672	6072	-1105	2693
PCNA	2253	4202	-3057	4382
PDPK1	-3330	144	2187	346
PHAX	1907	2467	-4010	5543
PHC1	-3898	601	-3043	-1211
PHC2	-2965	4301	4364	4886
PHC3	1703	519	-1430	4976
PHF1	-132	2932	-3605	1265
PHF19	265	2477	2562	-358
PHF20	723	2897	-2583	115
PIDD1	-2889	3339	-1370	-453
PIN1	-4611	3766	76	4014
PINK1	-4105	4744	3444	-715
PIP4K2A	-2845	5429	-2601	3045
PIP4K2B	-3801	1202	-3368	1071
PIP4K2C	231	5937	192	223
PLAGL1	3427	3318	3612	-782
PLD6	-4388	2910	-4550	5489
PLK2	-3522	8364	-356	5972
PLK3	-3521	2899	1409	3378
PMAIP1	-1795	7601	-4574	-1392
PML	1705	1158	976	4574
PMS2	1764	2713	-1686	5490
POLDIP3	-1158	1386	3841	3182
POLR1A	-3343	4109	-2198	131
POLR1B	539	3197	-4289	5605
POLR1C	2228	2648	-3560	5328
POLR1D	804	3932	385	6780
POLR1E	-1323	3976	-4639	1955
POLR2A	-2661	-175	2387	4046
POLR2B	2791	1490	-2187	5561
POLR2C	-1223	4488	-1052	6354
POLR2D	1826	1345	-3754	-614
POLR2E	-4070	2983	1998	3712
POLR2F	-4130	6520	2177	509
POLR2G	-3529	8023	2161	1604
POLR2H	-1987	7555	-1495	6297
POLR2I	-4150	6339	-662	5655
POLR2K	3699	2452	-1615	3853
POLR3A	386	3837	301	5225
POLR3C	3386	7974	466	3978
POLR3D	-2976	180	-3773	1967
POLR3E	-4047	6433	-3136	1113
POLR3F	3336	7901	-2866	-1022
POLR3G	587	7022	-3591	6659
POLR3GL	192	230	-854	204
POLR3H	-4544	6311	-4490	5544
POLR3K	926	708	710	891
POLRMT	-4432	1914	-3656	2155
POM121	-4007	5147	-934	4680
POM121C	-4243	5643	-2686	2061
POU2F1	3493	5425	2773	3909
POU2F2	1319	6047	2431	6365
PPARD	-3413	4443	-3320	-791
PPARGC1B	-2385	-738	1265	1449
PPM1A	1581	7664	1642	-136
PPM1D	3117	7800	1157	2649
PPP1R13B	-2773	1079	-3857	6428
PPP1R13L	-4572	5346	-2062	6543
PPP2CA	2133	7688	1877	2598
PPP2CB	3173	15	2037	2771
PPP2R1B	1368	607	-1191	6169
PPP2R5C	1533	5894	-3487	7072
PRDM1	2097	4081	-3471	1144
PRDX1	3650	4079	2239	510
PRDX2	999	6441	-1727	2503
PRDX5	-4482	7692	3252	4022
PRKAA1	3162	5613	-479	607
PRKAB1	2967	3175	3402	-840
PRKAB2	942	4048	-1766	3091
PRKACA	-1378	3969	4529	890
PRKAG1	3046	1524	2735	-1054
PRKAG2	2660	5977	-522	1021
PRKCB	-3677	4193	2655	4963
PRKCQ	-1185	3922	-4577	4207
PRKRA	3190	2918	-4244	2110
PRMT1	-3613	2063	-3476	2118
PRMT5	735	1328	678	2005
PRR5	-4233	4574	-4217	-347
PSMA1	2917	5206	1363	4758
PSMA2	1509	4929	-836	5163
PSMA3	4416	1432	-1823	3586
PSMA5	3047	4175	-2828	3319
PSMA6	3897	6144	1661	6676
PSMA7	-246	5863	3266	6901
PSMB1	-371	2981	-803	5409
PSMB10	-3433	689	-161	6388
PSMB2	835	-501	1803	1518
PSMB3	23	780	3778	4305
PSMB5	-2694	183	3229	269
PSMB6	-3103	5638	3472	5817
PSMB7	-2378	1587	2955	4198
PSMB8	949	1746	2054	5155
PSMB9	-217	3058	-3454	4468
PSMC1	928	2242	2194	1413
PSMC3	-2624	4680	847	736
PSMC4	-1230	1188	537	3431
PSMC5	-1694	2039	-2600	5094
PSMC6	4108	118	1373	2356
PSMD1	2911	5546	2375	56
PSMD11	4009	2032	2637	3521
PSMD12	4511	5250	2167	3681
PSMD13	-998	7807	1482	561
PSMD14	3360	3896	85	6314
PSMD2	-3334	6719	2097	3610
PSMD3	-4637	3063	1629	5579
PSMD4	-1530	1685	3940	5313
PSMD6	1854	3171	3275	2336
PSMD7	3595	864	596	2079
PSMD8	-2435	7747	2069	4665
PSMD9	-3510	-186	3384	3375
PSME1	1353	7210	-2849	1614
PSME2	3304	7208	-1478	778
PSME3	802	6539	2470	5231
PSME4	3349	7885	-461	5908
PSMF1	-1946	2260	416	7179
PTEN	2106	3654	2736	4814
PTPN1	-1209	-294	3707	699
PTPN11	-256	3762	1122	5061
PTPN4	-398	1836	-4481	784
RABGGTA	-512	2206	1774	4690
RABGGTB	2965	8153	-1723	7204
RAD1	2504	2828	-4477	-31
RAD17	3710	2101	-3529	5342
RAD50	3879	177	-1693	247
RAD51	2354	3943	-678	5266
RAD51D	-1149	8365	-1697	4329
RAD9A	-702	6453	-2172	5965
RAD9B	3403	-276	3262	-246
RAE1	2280	705	1931	2634
RAN	1899	2279	-3437	1483
RANBP2	2136	4418	-1280	5164
RARA	-1793	2133	4383	2132
RARG	-1979	3347	-1625	297
RB1	2559	1511	3713	1119
RBBP4	2299	2563	-1974	4061
RBBP5	1539	5828	-2066	2829
RBBP8	4281	1060	2231	1329
RBL1	-545	3150	-2999	5255
RBL2	-2568	417	-4609	-479
RBM14	-3212	5280	-189	5597
RBPJ	3616	3970	3767	1033
RBX1	1451	6206	1453	5881
RELA	-4376	5729	-1050	4332
RFC2	-287	6011	1863	4261
RFC3	2939	1596	-4063	2737
RFC4	3684	4888	-3526	5076
RFC5	326	7793	-1655	4210
RFFL	-1434	5164	-766	1095
RGCC	-72	882	-4221	7229
RHEB	3545	6668	1728	6309
RHNO1	1151	8178	-2115	511
RICTOR	2489	4606	-2585	2833
RING1	-4454	4511	-308	1003
RMI2	4204	4650	1781	-1674
RNF111	2625	5548	609	6047
RNF2	3358	7473	-879	2513
RNF34	3724	5286	-1181	1414
RNGTT	2340	1731	365	14
RNMT	3322	2739	-2660	6869
RNPS1	-2473	2186	-3151	537
RORA	-1351	7045	-4542	6931
RPA1	-1995	8052	-4589	6280
RPA3	867	1324	-3702	2526
RPAP2	403	6128	-147	2798
RPRD1A	3085	6217	561	3830
RPRD2	-30	3680	-2500	4609
RPS27A	-3731	2481	-4078	2589
RPTOR	-2242	-221	-887	5594
RRAGA	-1303	8282	3010	6804
RRAGC	3546	6994	-629	5283
RRAGD	839	3965	1919	-1654
RRM2	1136	5463	-2512	4439
RRM2B	4154	3032	844	1208
RRN3	1706	6484	-4239	2204
RTF1	2988	4098	229	6568
RUNX1	2495	3257	3425	193
RUNX2	293	5178	-4582	2447
RUNX3	-3366	4812	-4197	6758
RYBP	3191	807	1098	6817
SAP130	-721	6553	2448	5019
SAP18	-329	6215	661	5885
SAP30	-175	5406	3327	1163
SAP30BP	289	3703	874	5731
SAP30L	-3446	5381	739	5023
SATB2	2418	8225	4068	2932
SCMH1	-2646	7070	-3805	95
SCO1	148	2213	-493	6271
SCO2	1443	234	572	3284
SEC13	-1298	7330	2552	6209
SEH1L	3665	6621	-4109	3577
SESN1	-620	4577	-2934	4660
SESN2	-899	1601	2636	-84
SESN3	3250	3629	-1305	4704
SETD1A	-3879	867	-2413	-815
SETD1B	-2187	492	2565	2093
SETD9	-1593	2553	-2141	-411
SFN	-2816	-551	990	-1777
SGK1	-4707	3673	-2318	-1192
SIN3A	-1818	1522	-4181	3819
SIN3B	-1353	-269	1099	-419
SIRT1	3057	6792	-3490	6545
SIRT3	-1278	5327	465	661
SKI	-1514	2376	-2042	2897
SKIL	3155	3949	2557	3946
SKP1	3454	3180	-2543	2680
SKP2	4229	3426	-225	1707
SLBP	2900	6823	-2054	428
SLC2A3	-2653	4133	3706	-1209
SLC38A9	1594	6413	2203	6115
SLU7	4019	1803	-717	1094
SMAD1	1668	3536	4577	206
SMAD2	3578	1109	1380	1865
SMAD3	-571	5305	-2989	-363
SMAD4	3753	772	-2633	-1923
SMAD6	3527	8078	3978	5258
SMAD7	-4228	4704	-1899	1420
SMARCA2	-2884	7791	-1149	6061
SMARCA4	-3629	2881	2224	6790
SMARCA5	3556	1321	-2702	-466
SMARCB1	-542	5662	119	6566
SMARCC1	-1183	7979	-3324	2301
SMARCC2	-1500	3416	2279	5958
SMARCD1	-605	1602	-1898	-130
SMARCD2	-2997	6229	2631	3941
SMARCE1	-1640	5135	-1081	3183
SMURF1	-765	197	1222	6932
SMURF2	1161	4750	-3814	3523
SMYD2	825	8262	-2581	6310
SNAPC1	2052	-42	-1931	2196
SNAPC2	-2952	140	3063	-575
SNAPC3	4495	5421	1956	685
SNAPC4	-4010	3161	1800	5249
SNAPC5	2617	3902	-215	4906
SNRPB	-2032	7594	-1468	4947
SNRPD3	795	6797	-1853	-377
SNRPE	175	5854	-3125	3730
SNRPG	3070	6466	1508	3411
SNW1	3539	3975	580	2517
SOCS3	-4725	693	4095	6490
SOCS4	4288	2458	-1194	4738
SOD2	177	6323	3199	6132
SP1	-240	2139	3000	4864
SPI1	273	3222	4507	-1983
SRC	-1769	-92	-2399	-1474
SREBF1	-2674	5362	-317	2475
SRRM1	4398	6138	-860	3813
SRRT	-1902	844	-1354	1308
SRSF11	2689	7829	-3580	-51
SRSF2	464	3247	-2180	212
SRSF3	3264	185	-2400	-1223
SRSF4	383	-515	2645	6865
SRSF7	2068	4748	-1973	618
SRSF9	-643	8057	3465	745
SSB	4456	1729	-2923	4890
SSRP1	-2200	2939	-4241	770
SSU72	1661	2263	1779	2386
STAT1	3698	949	-4441	4969
STK11	-4042	2650	-14	750
STUB1	-4241	3481	-957	2320
SUDS3	2352	3059	358	1432
SUMO1	3870	4413	1420	3368
SUPT16H	1095	2231	-4549	4838
SUPT4H1	456	7494	1328	5916
SUPT5H	-3482	5357	-1088	2020
SUPT6H	-2963	842	601	1349
SURF1	-393	4035	1630	-170
SYMPK	70	3596	1744	2886
TACO1	-4351	1962	-2082	-240
TAF10	-2898	2736	3857	5287
TAF11	3713	-259	1371	882
TAF12	2090	483	3244	3413
TAF13	4172	3301	2774	3627
TAF15	-3570	7179	-1461	4236
TAF1A	2990	6982	-3080	4831
TAF1B	4464	-469	-1538	-322
TAF1C	-2779	5476	1173	1350
TAF1D	4413	6960	-2976	5422
TAF2	4316	1405	524	292
TAF3	3048	7243	-2602	1363
TAF4	-2601	5620	587	554
TAF4B	-385	711	-3663	4705
TAF5	2730	2994	-2354	3430
TAF6	-2356	4393	1401	6841
TAF7	415	6626	-168	455
TAF8	-183	5610	1716	5524
TAF9	4192	754	-2928	4395
TARBP2	-4242	4458	217	3789
TBL1XR1	4074	1360	546	2633
TCEA1	3045	2730	-3390	4153
TCF12	-194	-80	620	-542
TCF3	-2670	3008	-2351	-374
TCF7	-3466	7591	-4677	6949
TCF7L2	4370	2006	4568	1660
TDG	3510	-707	1410	-1069
TDRKH	315	6921	-3519	817
TET1	-1961	291	-3649	5293
TET3	-3125	-723	3632	7235
TFAM	308	2581	-4248	1500
TFAP2E	-4383	8013	-140	-857
TFDP1	3198	468	1695	2953
TFDP2	-3609	3755	-4460	-1476
TGFA	-2177	7641	3789	4631
TGFB1	-3576	4335	-268	3769
TGIF1	-1589	430	-2345	-390
TGIF2	-592	2244	-3370	-1903
THOC1	3589	7129	-2135	6021
THOC5	955	4206	3843	3364
THOC7	4273	3728	538	5592
THRA	-4260	1752	-2852	761
TIGAR	4013	4283	2689	5174
TMEM219	-250	3548	-27	1282
TNFRSF10A	240	4911	-1359	2821
TNFRSF10B	-1038	4835	2879	-670
TNFRSF10D	-3781	2595	2566	3086
TNKS1BP1	-3500	1203	-3259	3401
TNRC6A	3327	6066	302	5196
TNRC6B	88	782	-383	7057
TOP3A	-1121	4383	3364	3073
TOPBP1	3248	7052	-751	3545
TP53	-1807	1985	-4011	2709
TP53BP2	2975	-428	2300	-1532
TP53I3	1436	6452	4579	2407
TP53INP1	1607	4756	2259	3584
TP53RK	-53	6071	-4127	2847
TPR	1846	5115	-1721	4615
TPX2	475	1454	-1030	261
TRIAP1	1439	3899	-1876	6158
TRIM28	-4288	3404	-3668	3596
TRIM33	3725	4285	-575	6678
TSC1	-514	6027	1193	4695
TSC2	-3080	5070	1798	3951
TSN	2592	1070	-2579	4854
TSNAX	3604	2635	-851	7133
TTC5	8	2874	-342	3420
TTF1	3788	288	-1126	3536
TXN	1873	336	3237	-1733
TXNIP	4106	3959	-1903	6152
TXNRD1	1650	211	3064	-1400
U2AF1	-276	6502	1471	1030
U2AF1L4	-1709	-451	387	5614
U2AF2	-4347	6388	346	6130
UBA52	-3208	4386	-596	-69
UBB	-2084	561	-996	5058
UBC	-1739	2624	1876	3220
UBE2C	-167	1577	-861	4534
UBE2D1	1930	4687	3454	2741
UBE2D3	3202	2444	2392	3005
UBE2E1	3227	3136	113	2408
UBE2I	-2546	3641	225	5794
UBE2S	-993	-545	895	-706
UBTF	-3527	618	-4165	1855
UHRF1	490	3724	651	6171
USP7	-1481	1987	813	3259
VDR	2207	2682	4559	3980
VEGFA	-3059	827	1628	87
WDR33	2305	7055	-106	3468
WDR5	-2333	4701	-676	1100
WDR61	1345	2434	-528	1522
WRN	1545	7122	-4272	6294
WWOX	-4433	81	-3515	4711
WWP1	3419	4683	-4565	479
XPO5	-492	6269	-3486	5411
YAF2	4480	-729	-458	-1485
YEATS4	731	3235	-3987	4456
YES1	677	-619	-2471	5197
YWHAB	4207	4074	788	2152
YWHAE	2448	6182	3206	1288
YWHAG	-1658	5656	3774	1919
YWHAH	1174	3456	3029	-1274
YWHAQ	972	1310	-2670	3225
YWHAZ	3562	2726	-278	4293
YY1	-4104	2745	-3291	1468
ZC3H8	1326	4001	-4236	1561
ZFHX3	-885	8021	2769	6883
ZFP1	2472	812	-3883	2171
ZFP14	2803	1128	-1524	5518
ZFP28	-3421	8069	-4215	2617
ZFP30	1985	3179	-3027	37
ZFP37	3425	8383	-2666	5349
ZFP90	483	505	-2441	4023
ZFPM1	-4718	1201	-2586	6829
ZIK1	-3058	-624	-4533	1200
ZKSCAN1	1029	4583	-352	3832
ZKSCAN3	2298	829	655	-582
ZKSCAN4	1958	4795	878	1247
ZKSCAN5	-424	3377	1337	732
ZKSCAN8	708	348	-2644	-1982
ZNF10	1794	5876	-2926	5982
ZNF101	2041	4347	-3363	5647
ZNF136	2737	7206	-4492	1381
ZNF138	724	1237	-3707	2889
ZNF14	2894	2835	-4288	2143
ZNF140	3986	5109	-2529	5705
ZNF141	2078	7393	-2966	5325
ZNF143	2244	986	-354	5193
ZNF155	-337	6062	-578	3581
ZNF160	3472	-529	1234	-597
ZNF169	213	993	-87	-198
ZNF17	455	6330	-3226	4404
ZNF175	-759	2865	-2729	3286
ZNF18	2116	680	3070	-140
ZNF180	-154	6771	-2821	2630
ZNF184	1149	-503	-4113	2160
ZNF189	2176	-341	-513	1728
ZNF19	1514	3994	-1127	-906
ZNF2	-116	4537	-3234	2263
ZNF20	3201	8005	2521	4018
ZNF200	3543	2015	277	5251
ZNF202	1911	1785	-4074	-391
ZNF211	1036	7488	-3933	5487
ZNF212	-2880	450	-2705	1817
ZNF213	-4490	1334	3875	2868
ZNF215	3453	-718	674	-1503
ZNF221	1067	5246	-1184	-1000
ZNF222	472	7750	-1104	3892
ZNF223	-1387	7758	-1284	880
ZNF224	2542	4171	-903	2025
ZNF226	1871	5790	-1948	3324
ZNF227	1482	345	-2485	808
ZNF23	2676	3459	-2783	-45
ZNF233	775	-842	-549	-1821
ZNF234	1182	7976	-1459	6390
ZNF235	900	1465	-2008	-827
ZNF248	392	43	-3524	3065
ZNF25	2286	3535	1175	2002
ZNF250	-544	1875	-998	720
ZNF253	-340	2931	-3722	5992
ZNF257	743	7995	-3544	6729
ZNF26	2780	-821	-1968	335
ZNF264	-230	2775	-1586	-325
ZNF268	4076	5502	-1718	717
ZNF274	-2905	5939	-2857	-269
ZNF282	-4549	6885	2144	820
ZNF286A	-1679	6950	-4437	5051
ZNF287	-1599	4149	-4464	867
ZNF3	1609	2818	-3418	3563
ZNF302	887	3958	-3938	2690
ZNF324	-3289	6481	-2890	4647
ZNF324B	-3614	7944	-1673	3238
ZNF331	-3140	1023	-3842	-492
ZNF333	2077	1078	3140	3278
ZNF337	-2462	1477	-4080	956
ZNF33A	2690	275	-2017	656
ZNF33B	-830	2199	-4604	4398
ZNF34	-3017	2480	958	486
ZNF343	-1527	5579	-3289	837
ZNF354A	3656	4421	881	4627
ZNF354C	-389	7482	-4040	439
ZNF382	3072	3863	36	6292
ZNF394	-2390	42	645	1889
ZNF398	-1746	6959	-2147	4258
ZNF417	-2536	7002	-2823	6886
ZNF418	-2633	7815	-1179	-1271
ZNF419	-2663	4353	-2958	-1241
ZNF420	2099	1197	-4576	1738
ZNF425	-3197	7244	-1985	6235
ZNF426	2434	4524	-1155	-356
ZNF43	3802	6526	-3817	5316
ZNF430	4052	5202	-3841	-1126
ZNF431	2023	5654	-4303	5326
ZNF432	1310	2245	-3349	4335
ZNF436	-1283	1972	-1741	3369
ZNF440	1698	8155	-1253	6884
ZNF443	1947	1584	-359	174
ZNF445	203	4325	3123	322
ZNF446	-4172	4045	-3309	676
ZNF461	3023	1388	-2427	2022
ZNF468	3105	-726	2490	-1499
ZNF470	-3496	7987	-2731	5112
ZNF480	194	8131	-2371	3110
ZNF483	3818	7855	-3185	3488
ZNF484	1949	5315	-2373	-1056
ZNF490	1229	7836	1608	4419
ZNF492	2130	8099	-2874	2700
ZNF496	-2856	6837	-1283	2746
ZNF500	-1797	7171	-1469	2619
ZNF506	4415	876	-2648	1927
ZNF517	-3853	5073	-4146	6890
ZNF528	-482	2747	-2348	-1159
ZNF529	3215	7143	-3261	6133
ZNF530	-1672	8275	-4546	5648
ZNF540	2204	6611	-3232	1989
ZNF546	3515	5978	75	4960
ZNF547	2172	5432	261	5027
ZNF549	-1485	6584	-4531	3573
ZNF550	1343	7710	-3245	-650
ZNF552	-94	5669	2840	3735
ZNF554	1190	3747	-3709	3039
ZNF559	516	4276	-3916	3388
ZNF561	2860	8206	-1927	3917
ZNF563	1977	8326	-2952	6434
ZNF564	4138	5415	-2635	5903
ZNF566	3964	8019	-4386	2789
ZNF567	3559	4730	-4085	4983
ZNF568	-1287	-424	-4226	-177
ZNF569	2503	7615	-1157	1805
ZNF570	3811	3358	-3344	-836
ZNF571	-1748	4161	-3462	6811
ZNF573	1103	773	-1654	1491
ZNF582	1909	1322	-3190	2353
ZNF583	680	2382	-4232	230
ZNF584	-2126	5839	-2994	-1260
ZNF585A	3924	5722	-685	6256
ZNF585B	2613	4808	-1015	3175
ZNF587	-2154	8233	1085	4917
ZNF589	1782	3543	1734	5514
ZNF596	425	1006	-951	-1898
ZNF597	902	-430	-3361	3305
ZNF600	-2810	2520	-3152	-1256
ZNF605	1124	1029	-1806	-1066
ZNF606	-1577	8374	-2129	3490
ZNF610	209	6133	-1975	4540
ZNF611	-88	4169	1496	2480
ZNF613	4051	4739	1459	6558
ZNF614	923	4890	-3391	6320
ZNF615	1197	4671	-1047	2660
ZNF619	1150	3704	-84	-1437
ZNF620	1516	3333	-1321	-1050
ZNF621	3280	6998	-2138	1639
ZNF624	2373	4055	-1827	19
ZNF627	-277	7011	-1486	268
ZNF641	376	5827	-253	-1170
ZNF655	1825	3973	364	5617
ZNF664	653	4126	-3989	1404
ZNF665	2058	7067	77	3845
ZNF668	-4641	4217	422	-545
ZNF670	3380	1403	41	-578
ZNF671	-1886	7510	-4325	1792
ZNF677	-1394	7542	-2274	2486
ZNF678	1874	1992	-3844	3886
ZNF681	602	6019	-4264	6565
ZNF684	3182	1607	-911	3999
ZNF688	-3524	4302	151	1886
ZNF689	-1939	6434	-1425	2936
ZNF691	2896	4040	1320	2013
ZNF692	-2243	5209	-953	1658
ZNF696	-3668	3297	-3839	-563
ZNF70	-655	5224	-1715	399
ZNF700	2888	6341	275	1456
ZNF701	122	4215	1908	2213
ZNF703	-1983	5494	284	-229
ZNF706	2346	2961	-1969	-1327
ZNF707	-3495	4686	-3492	977
ZNF708	2792	3592	-3910	1382
ZNF709	-347	2388	-731	6109
ZNF710	-2093	7914	4422	-1776
ZNF713	3937	-587	1637	-703
ZNF714	3819	4591	-2550	5272
ZNF717	338	-441	-214	566
ZNF736	2876	7966	-2487	6092
ZNF737	2283	4397	-3662	2021
ZNF74	-4619	2585	-4022	4956
ZNF740	-1907	7314	-3004	5116
ZNF746	-2129	2203	3625	512
ZNF747	-4466	5947	-64	6501
ZNF749	-568	-796	-4026	-1831
ZNF75A	-461	8355	-2509	7084
ZNF761	1275	801	-2961	-599
ZNF764	-2680	6110	-210	6184
ZNF77	2403	-676	-2243	179
ZNF771	484	1715	-2947	547
ZNF772	-1743	7142	-3089	5397
ZNF774	1331	7382	3128	4929
ZNF775	-4692	4838	260	2200
ZNF776	-2190	796	-1612	5897
ZNF777	-4413	3226	-3266	4581
ZNF778	-4062	6601	73	5259
ZNF782	262	1219	-1984	-705
ZNF785	-3449	6358	-1080	1396
ZNF786	-160	2108	-3705	-224
ZNF79	1402	7290	266	2360
ZNF790	1234	7989	-960	1406
ZNF791	1085	7582	-1066	6429
ZNF792	-4066	63	-3572	332
ZNF793	1789	6733	-3097	1232
ZNF799	149	8079	-2929	3846
ZNF839	-1066	3034	1279	-1103
ZNF92	3464	5341	-2041	3537
ZSCAN25	-4315	-840	-3402	7056

---

---

Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs

metric	value
setSize	122
pMANOVA	7.41e-14
p.adjustMANOVA	2.87e-12
s.dist	0.437
s.t0_crp_RNA	-0.28
s.t0_crp_meth	-0.0504
s.pod_crp_RNA	-0.269
s.pod_crp_meth	0.195
p.t0_crp_RNA	9.97e-08
p.t0_crp_meth	0.339
p.pod_crp_RNA	3.26e-07
p.pod_crp_meth	0.000202

Warning in xtfrm.data.frame(x): cannot xtfrm data frames

Top 20 genes

Gene	t0_crp_RNA	pod_crp_RNA
RPS2	-4698	-4571
RPL3	-4508	-4610
RPLP2	-4667	-3815
RPS5	-4113	-4065
RPS12	-4261	-3896
RPLP0	-4068	-4060
RPL27A	-4061	-3904
RPS3	-3753	-4143
RPS27A	-3731	-4078
RPS16	-4379	-3448
RPL29	-3990	-3643
RPS10	-4168	-3457
RPL37	-4723	-2971
RPL35	-3999	-3508
RPS29	-4598	-3034
RPS18	-4218	-3284
RPS6	-3204	-4317
RPL18A	-3938	-3444
RPS23	-3376	-3858
RPL38	-4417	-2941

Click HERE to show all gene set members

All member genes

	t0_crp_RNA	t0_crp_meth	pod_crp_RNA	pod_crp_meth
CASC3	-2211	3328	2647	5105
CUL2	4307	5990	178	2207
DAG1	-2173	2752	937	-94
EIF4A3	-2476	5309	-384	4597
EIF4G1	-3029	3207	3785	5764
ETF1	3017	7097	1676	151
FAU	-4223	5971	-437	6875
GSPT1	2757	4351	-2932	-1153
LDB1	-3986	4788	-1318	1166
NCBP1	4110	6523	-472	5857
NCBP2	4266	3714	-3787	4776
PABPC1	1721	3723	-1442	3011
PSMA1	2917	5206	1363	4758
PSMA2	1509	4929	-836	5163
PSMA3	4416	1432	-1823	3586
PSMA5	3047	4175	-2828	3319
PSMA6	3897	6144	1661	6676
PSMA7	-246	5863	3266	6901
PSMB1	-371	2981	-803	5409
PSMB10	-3433	689	-161	6388
PSMB2	835	-501	1803	1518
PSMB3	23	780	3778	4305
PSMB5	-2694	183	3229	269
PSMB6	-3103	5638	3472	5817
PSMB7	-2378	1587	2955	4198
PSMB8	949	1746	2054	5155
PSMB9	-217	3058	-3454	4468
PSMC1	928	2242	2194	1413
PSMC3	-2624	4680	847	736
PSMC4	-1230	1188	537	3431
PSMC5	-1694	2039	-2600	5094
PSMC6	4108	118	1373	2356
PSMD1	2911	5546	2375	56
PSMD11	4009	2032	2637	3521
PSMD12	4511	5250	2167	3681
PSMD13	-998	7807	1482	561
PSMD14	3360	3896	85	6314
PSMD2	-3334	6719	2097	3610
PSMD3	-4637	3063	1629	5579
PSMD4	-1530	1685	3940	5313
PSMD6	1854	3171	3275	2336
PSMD7	3595	864	596	2079
PSMD8	-2435	7747	2069	4665
PSMD9	-3510	-186	3384	3375
PSME1	1353	7210	-2849	1614
PSME2	3304	7208	-1478	778
PSME3	802	6539	2470	5231
PSME4	3349	7885	-461	5908
PSMF1	-1946	2260	416	7179
RBX1	1451	6206	1453	5881
RNPS1	-2473	2186	-3151	537
RPL10A	-2021	3601	-3665	3590
RPL11	-2195	4759	-3631	-495
RPL13	-2399	2561	-2415	6187
RPL13A	-2217	1446	-4059	5521
RPL14	-2732	1645	-4433	-798
RPL15	-2979	2857	-3337	1424
RPL17	-3043	1594	-3926	2296
RPL18	-3380	7714	-3552	4478
RPL18A	-3938	751	-3444	4254
RPL22	-2825	5674	-4182	1020
RPL23	-1858	5701	-3100	2729
RPL23A	48	7818	-4430	4559
RPL26	-2272	4855	-3465	6407
RPL26L1	-972	2107	2314	3971
RPL27A	-4061	5311	-3904	1697
RPL28	-2225	2129	-798	4754
RPL29	-3990	4921	-3643	2875
RPL3	-4508	360	-4610	6751
RPL31	-3651	495	-3411	-34
RPL32	-3564	4776	-3623	5998
RPL34	-904	906	-3944	6513
RPL35	-3999	2909	-3508	4823
RPL36	-4523	-158	-2815	2877
RPL36AL	-4195	7236	-1732	6350
RPL37	-4723	3433	-2971	5392
RPL37A	-3969	1847	-2033	4981
RPL38	-4417	4342	-2941	4430
RPL39L	-2468	4218	-28	5079
RPL4	-2456	997	-4254	1394
RPL41	-3631	4792	-2682	821
RPL6	466	3352	-3950	1979
RPL7	-2841	5004	-4292	7008
RPL8	-4442	7620	-2781	5093
RPL9	-990	4307	-3377	844
RPLP0	-4068	5078	-4060	4850
RPLP1	-4307	4259	-1607	1521
RPLP2	-4667	3685	-3815	6421
RPS10	-4168	2356	-3457	3925
RPS11	-3884	1199	-3013	4224
RPS12	-4261	7672	-3896	6329
RPS15	-3350	1899	-2308	5621
RPS15A	-3437	1657	-3621	6110
RPS16	-4379	4270	-3448	5979
RPS18	-4218	4809	-3284	4162
RPS19	-3954	1402	-2451	-362
RPS2	-4698	-704	-4571	6973
RPS20	-1234	4742	-3936	3461
RPS23	-3376	-353	-3858	2986
RPS24	-35	6157	-2288	-518
RPS25	-2395	138	-4129	1797
RPS26	-1529	6099	-2398	5515
RPS27A	-3731	2481	-4078	2589
RPS27L	3563	2925	1087	1405
RPS28	-4025	17	-2863	-1178
RPS29	-4598	3919	-3034	5600
RPS3	-3753	4053	-4143	4598
RPS3A	1196	4024	-4365	7066
RPS5	-4113	3314	-4065	6070
RPS6	-3204	4732	-4317	361
RPS7	-2809	3926	-3695	4407
RPS8	-1253	-347	-3213	-79
RPS9	-3353	1940	922	627
RPSA	1973	687	-1923	2072
SLIT1	-1399	4555	3673	-1568
UBA52	-3208	4386	-596	-69
UBB	-2084	561	-996	5058
UBC	-1739	2624	1876	3220
UPF2	3948	4005	-99	3840
UPF3A	-1847	6389	-3579	6961
USP33	4141	-214	-734	774
ZSWIM8	-3912	4663	4003	-1419

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.1.0 (2021-05-18)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.1    GGally_2.1.1     ggplot2_3.3.3    reshape2_1.4.4  
##  [5] beeswarm_0.3.1   gtools_3.8.2     tibble_3.1.2     dplyr_1.0.6     
##  [9] echarts4r_0.4.0  kableExtra_1.3.4 mitch_1.4.0      gplots_3.1.1    
## 
## loaded via a namespace (and not attached):
##  [1] httr_1.4.2         sass_0.4.0         jsonlite_1.7.2     viridisLite_0.4.0 
##  [5] bslib_0.2.5.1      shiny_1.6.0        assertthat_0.2.1   highr_0.9         
##  [9] yaml_2.2.1         progress_1.2.2     pillar_1.6.1       glue_1.4.2        
## [13] digest_0.6.27      RColorBrewer_1.1-2 promises_1.2.0.1   rvest_1.0.0       
## [17] colorspace_2.0-1   htmltools_0.5.1.1  httpuv_1.6.1       plyr_1.8.6        
## [21] pkgconfig_2.0.3    purrr_0.3.4        xtable_1.8-4       scales_1.1.1      
## [25] webshot_0.5.2      svglite_2.0.0      later_1.2.0        generics_0.1.0    
## [29] farver_2.1.0       ellipsis_0.3.2     withr_2.4.2        magrittr_2.0.1    
## [33] crayon_1.4.1       mime_0.10          evaluate_0.14      fansi_0.5.0       
## [37] MASS_7.3-54        xml2_1.3.2         prettyunits_1.1.1  tools_4.1.0       
## [41] hms_1.1.0          lifecycle_1.0.0    stringr_1.4.0      munsell_0.5.0     
## [45] compiler_4.1.0     jquerylib_0.1.4    caTools_1.18.2     systemfonts_1.0.2 
## [49] rlang_0.4.11       grid_4.1.0         rstudioapi_0.13    htmlwidgets_1.5.3 
## [53] bitops_1.0-7       labeling_0.4.2     rmarkdown_2.8      gtable_0.3.0      
## [57] DBI_1.1.1          reshape_0.8.8      R6_2.5.0           gridExtra_2.3     
## [61] knitr_1.33         fastmap_1.1.0      utf8_1.2.1         rprojroot_2.0.2   
## [65] KernSmooth_2.23-20 desc_1.3.0         stringi_1.6.2      parallel_4.1.0    
## [69] Rcpp_1.0.6         vctrs_0.3.8        tidyselect_1.1.1   xfun_0.23

END of report