Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2021-08-13
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## RNA meth
## A1BG 2.6192564 -0.45188238
## AAAS -2.6372410 0.06143186
## AACS 0.1010134 0.13997068
## AAGAB 1.0702585 -0.59522248
## AAK1 -3.0047762 -0.32725606
## AAMDC 2.2859640 -0.21261544| Profile metrics | |
|---|---|
| num_genes_in_profile | 9311 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 2114 |
| num_profile_genes_not_in_sets | 7197 |
| profile_pearson_correl | -0.10543 |
| profile_spearman_correl | -0.08313 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets:| Gene sets metrics | |
|---|---|
| num_genesets | 15 |
| num_genesets_excluded | 0 |
| num_genesets_included | 15 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 15 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
Top N sets irrespective of FDR. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 15 gene sets| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.RNA | s.meth | p.RNA | p.meth |
|---|---|---|---|---|---|---|---|---|
| Neutrophil degranulation | 305 | 5.80e-54 | 8.69e-53 | 0.525 | 0.5230 | -0.04990 | 2.98e-55 | 1.38e-01 |
| Immune System | 1142 | 2.01e-30 | 1.51e-29 | 0.208 | 0.2020 | 0.04930 | 1.16e-28 | 6.86e-03 |
| Signaling by Receptor Tyrosine Kinases | 284 | 6.36e-13 | 3.18e-12 | 0.256 | 0.2530 | 0.04170 | 3.55e-13 | 2.30e-01 |
| Signaling by Interleukins | 263 | 1.38e-11 | 5.13e-11 | 0.253 | 0.2530 | 0.01510 | 2.56e-12 | 6.77e-01 |
| rRNA processing | 159 | 1.71e-11 | 5.13e-11 | 0.336 | -0.2890 | 0.17100 | 3.63e-10 | 2.07e-04 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 147 | 5.25e-11 | 1.31e-10 | 0.342 | -0.2830 | 0.19300 | 3.83e-09 | 5.68e-05 |
| Platelet activation, signaling and aggregation | 133 | 1.35e-08 | 2.90e-08 | 0.297 | 0.2910 | 0.06250 | 8.09e-09 | 2.15e-01 |
| Metabolism of RNA | 535 | 6.68e-08 | 1.21e-07 | 0.153 | -0.0918 | 0.12300 | 3.55e-04 | 1.72e-06 |
| Metabolism of lipids | 427 | 7.26e-08 | 1.21e-07 | 0.164 | 0.1640 | -0.00959 | 9.91e-09 | 7.37e-01 |
| Toll-like Receptor Cascades | 108 | 7.51e-07 | 1.13e-06 | 0.295 | 0.2950 | 0.00249 | 1.23e-07 | 9.64e-01 |
| Peptide chain elongation | 67 | 9.52e-07 | 1.30e-06 | 0.387 | -0.2450 | 0.30000 | 5.31e-04 | 2.26e-05 |
| Eukaryotic Translation Elongation | 70 | 1.15e-06 | 1.43e-06 | 0.377 | -0.2390 | 0.29100 | 5.70e-04 | 2.60e-05 |
| Toll Like Receptor 2 (TLR2) Cascade | 71 | 1.34e-06 | 1.54e-06 | 0.357 | 0.3570 | -0.00759 | 2.09e-07 | 9.12e-01 |
| rRNA modification in the nucleus and cytosol | 47 | 7.00e-05 | 7.50e-05 | 0.374 | -0.3660 | 0.07770 | 1.44e-05 | 3.58e-01 |
| alpha-linolenic acid (ALA) metabolism | 10 | 2.74e-04 | 2.74e-04 | 0.758 | 0.7100 | -0.26600 | 1.01e-04 | 1.45e-01 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.RNA | s.meth | p.RNA | p.meth |
|---|---|---|---|---|---|---|---|---|
| Neutrophil degranulation | 305 | 5.80e-54 | 8.69e-53 | 0.525 | 0.5230 | -0.04990 | 2.98e-55 | 1.38e-01 |
| Immune System | 1142 | 2.01e-30 | 1.51e-29 | 0.208 | 0.2020 | 0.04930 | 1.16e-28 | 6.86e-03 |
| Signaling by Receptor Tyrosine Kinases | 284 | 6.36e-13 | 3.18e-12 | 0.256 | 0.2530 | 0.04170 | 3.55e-13 | 2.30e-01 |
| Signaling by Interleukins | 263 | 1.38e-11 | 5.13e-11 | 0.253 | 0.2530 | 0.01510 | 2.56e-12 | 6.77e-01 |
| rRNA processing | 159 | 1.71e-11 | 5.13e-11 | 0.336 | -0.2890 | 0.17100 | 3.63e-10 | 2.07e-04 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 147 | 5.25e-11 | 1.31e-10 | 0.342 | -0.2830 | 0.19300 | 3.83e-09 | 5.68e-05 |
| Platelet activation, signaling and aggregation | 133 | 1.35e-08 | 2.90e-08 | 0.297 | 0.2910 | 0.06250 | 8.09e-09 | 2.15e-01 |
| Metabolism of RNA | 535 | 6.68e-08 | 1.21e-07 | 0.153 | -0.0918 | 0.12300 | 3.55e-04 | 1.72e-06 |
| Metabolism of lipids | 427 | 7.26e-08 | 1.21e-07 | 0.164 | 0.1640 | -0.00959 | 9.91e-09 | 7.37e-01 |
| Toll-like Receptor Cascades | 108 | 7.51e-07 | 1.13e-06 | 0.295 | 0.2950 | 0.00249 | 1.23e-07 | 9.64e-01 |
| Peptide chain elongation | 67 | 9.52e-07 | 1.30e-06 | 0.387 | -0.2450 | 0.30000 | 5.31e-04 | 2.26e-05 |
| Eukaryotic Translation Elongation | 70 | 1.15e-06 | 1.43e-06 | 0.377 | -0.2390 | 0.29100 | 5.70e-04 | 2.60e-05 |
| Toll Like Receptor 2 (TLR2) Cascade | 71 | 1.34e-06 | 1.54e-06 | 0.357 | 0.3570 | -0.00759 | 2.09e-07 | 9.12e-01 |
| rRNA modification in the nucleus and cytosol | 47 | 7.00e-05 | 7.50e-05 | 0.374 | -0.3660 | 0.07770 | 1.44e-05 | 3.58e-01 |
| alpha-linolenic acid (ALA) metabolism | 10 | 2.74e-04 | 2.74e-04 | 0.758 | 0.7100 | -0.26600 | 1.01e-04 | 1.45e-01 |
Detailed Gene set reports
Neutrophil degranulation
| metric | value |
|---|---|
| setSize | 305 |
| pMANOVA | 5.8e-54 |
| p.adjustMANOVA | 8.69e-53 |
| s.dist | 0.525 |
| s.RNA | 0.523 |
| s.meth | -0.0499 |
| p.RNA | 2.98e-55 |
| p.meth | 0.138 |
| Gene | RNA | meth |
|---|---|---|
| CKAP4 | 4355 | -6717 |
| MNDA | 4303 | -6779 |
| CYFIP1 | 4295 | -6630 |
| CTSZ | 4137 | -6765 |
| RAB3D | 4263 | -6515 |
| TRPM2 | 4205 | -6600 |
| QPCT | 4331 | -6405 |
| TLR2 | 4206 | -6586 |
| PLD1 | 4321 | -6058 |
| PYCARD | 3942 | -6598 |
| LAMTOR1 | 4371 | -5950 |
| BRI3 | 4159 | -6229 |
| P2RX1 | 3829 | -6722 |
| ATP6V0A1 | 4375 | -5877 |
| ALOX5 | 4150 | -6082 |
| CREG1 | 4403 | -5637 |
| GCA | 4384 | -5597 |
| C3AR1 | 3573 | -6729 |
| CAPN1 | 3902 | -6119 |
| PLAUR | 3822 | -6237 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| A1BG | 2170 | -3533 |
| ACAA1 | 3734 | 1410 |
| ACLY | 1961 | -5417 |
| ACTR10 | 3309 | -1291 |
| ACTR1B | -3828 | -3653 |
| ACTR2 | 3481 | -3374 |
| ADAM10 | 4030 | 976 |
| ADAM8 | 2208 | -5902 |
| ADGRE5 | -769 | -5511 |
| AGA | -1396 | -2458 |
| AGL | -940 | -3188 |
| AGPAT2 | 4289 | 2250 |
| ALAD | 3874 | -1369 |
| ALDOA | 4285 | -1349 |
| ALDOC | -1028 | -6226 |
| ALOX5 | 4150 | -6082 |
| AMPD3 | 3997 | -5620 |
| ANO6 | 3597 | -3634 |
| AP1M1 | 2798 | -2408 |
| APAF1 | 4158 | -2104 |
| APEH | 314 | 1724 |
| APRT | -834 | -204 |
| ARHGAP9 | 2545 | 2156 |
| ARL8A | 3713 | -6230 |
| ARMC8 | 2620 | -1033 |
| ARPC5 | 3968 | -3837 |
| ARSA | 1183 | -3099 |
| ARSB | 3290 | -5722 |
| ASAH1 | 3880 | 335 |
| ATAD3B | -3588 | -1948 |
| ATG7 | 3647 | 569 |
| ATP11A | 3801 | -5671 |
| ATP11B | 2429 | 1806 |
| ATP6V0A1 | 4375 | -5877 |
| ATP6V0C | 4218 | -4697 |
| ATP6V1D | 4174 | -1234 |
| ATP8A1 | -4599 | -250 |
| ATP8B4 | 2945 | 1090 |
| B2M | -2195 | -2389 |
| B4GALT1 | 1540 | -160 |
| BIN2 | 2264 | -2805 |
| BRI3 | 4159 | -6229 |
| BST2 | -2378 | -1970 |
| C3AR1 | 3573 | -6729 |
| C6orf120 | 2508 | 1218 |
| CAB39 | 3728 | -2802 |
| CAND1 | -2041 | -421 |
| CAP1 | 3635 | -553 |
| CAPN1 | 3902 | -6119 |
| CAT | 4214 | -3922 |
| CCT2 | -3002 | -727 |
| CCT8 | 2708 | -1245 |
| CD300A | -641 | -6466 |
| CD44 | 3760 | 266 |
| CD47 | -4754 | -114 |
| CD53 | 3492 | 2243 |
| CD55 | 4229 | -3923 |
| CD58 | 2766 | -3228 |
| CD59 | 2326 | -6024 |
| CD63 | 4308 | -1017 |
| CDK13 | -2814 | -700 |
| CEACAM1 | 3825 | -5827 |
| CEP290 | -3161 | -2056 |
| CKAP4 | 4355 | -6717 |
| CMTM6 | 3495 | -3483 |
| CNN2 | 2764 | 1735 |
| COMMD3 | -426 | -6772 |
| COMMD9 | 3544 | -4811 |
| COPB1 | 3154 | -1329 |
| COTL1 | 3526 | 2411 |
| CPNE1 | -1012 | 1274 |
| CPNE3 | 2335 | -2088 |
| CPPED1 | 3772 | -3919 |
| CREG1 | 4403 | -5637 |
| CSNK2B | 1389 | -998 |
| CSTB | 2911 | -2676 |
| CTSA | 4412 | -4847 |
| CTSB | 4350 | -4209 |
| CTSC | 739 | 1561 |
| CTSD | 4381 | 1642 |
| CTSS | 3785 | -2958 |
| CTSZ | 4137 | -6765 |
| CYB5R3 | 4090 | -1540 |
| CYBA | 2922 | 1006 |
| CYFIP1 | 4295 | -6630 |
| CYSTM1 | 4193 | -5233 |
| DBNL | 3411 | -3713 |
| DEGS1 | 2496 | -193 |
| DERA | 3866 | -756 |
| DGAT1 | 2033 | -6115 |
| DIAPH1 | -283 | 1033 |
| DNAJC13 | 3719 | -4825 |
| DNAJC3 | 3828 | -2353 |
| DNAJC5 | 3964 | -5119 |
| DPP7 | -1381 | -1037 |
| DSN1 | -3971 | 369 |
| DYNC1H1 | -2492 | 1504 |
| DYNC1LI1 | 2930 | -2912 |
| DYNLL1 | 2378 | -3319 |
| DYNLT1 | 1622 | 1458 |
| EEF1A1 | -1549 | 720 |
| EEF2 | 90 | 2127 |
| ENPP4 | -3342 | -1178 |
| ERP44 | 2912 | 1942 |
| FABP5 | 2411 | -3534 |
| FAF2 | 2168 | -4965 |
| FGR | 3853 | -5292 |
| FTH1 | 1827 | -521 |
| FTL | 3957 | -4621 |
| FUCA1 | 3203 | -5579 |
| FUCA2 | 3743 | -427 |
| GAA | 3545 | -3801 |
| GALNS | 3034 | -854 |
| GCA | 4384 | -5597 |
| GDI2 | 3138 | -587 |
| GGH | 2515 | -2788 |
| GHDC | 1470 | -5520 |
| GLB1 | 3992 | 1368 |
| GLIPR1 | 3403 | -2351 |
| GM2A | 4180 | -825 |
| GMFG | 3717 | -2699 |
| GNS | 4348 | -571 |
| GOLGA7 | 1429 | -2970 |
| GPI | 2558 | -2211 |
| GRN | 4323 | -4414 |
| GSDMD | 614 | -3378 |
| GSTP1 | 35 | -5415 |
| GUSB | 3389 | -4967 |
| GYG1 | 4157 | -5541 |
| HEBP2 | 3803 | -1822 |
| HEXB | 4022 | -5777 |
| HGSNAT | 583 | 2126 |
| HLA-A | -771 | -5991 |
| HLA-B | 205 | 1015 |
| HLA-C | 321 | -25 |
| HLA-H | -1158 | -101 |
| HMGB1 | -86 | -1263 |
| HMOX2 | -4583 | 2130 |
| HSP90AA1 | 411 | -781 |
| HSP90AB1 | -2171 | -5745 |
| HSPA1A | 3613 | -3825 |
| HSPA1B | 2669 | -513 |
| HVCN1 | 1834 | -217 |
| IDH1 | 4409 | -2333 |
| IGF2R | 3062 | -5512 |
| ILF2 | -597 | -3803 |
| IMPDH1 | 4313 | -750 |
| IMPDH2 | -3507 | 446 |
| IQGAP1 | 3661 | 1271 |
| IQGAP2 | 2738 | -246 |
| IST1 | 2328 | -3896 |
| ITGAL | -4012 | 2268 |
| ITGAV | 2457 | -5201 |
| ITGB2 | 4114 | 1322 |
| KCMF1 | 3480 | -3080 |
| KCNAB2 | -31 | -6014 |
| KPNB1 | 776 | -2176 |
| LAIR1 | 3084 | -6275 |
| LAMP1 | 3329 | -376 |
| LAMTOR1 | 4371 | -5950 |
| LAMTOR2 | 3287 | 1882 |
| LAMTOR3 | 3292 | 321 |
| LPCAT1 | -2399 | 1540 |
| LTA4H | 4292 | -972 |
| MAN2B1 | 2897 | -6345 |
| MANBA | 3188 | 1807 |
| MAPK1 | 3249 | 1865 |
| MAPK14 | 4207 | -3529 |
| MIF | -1146 | -2943 |
| MLEC | 737 | 953 |
| MMP25 | 3875 | 1010 |
| MNDA | 4303 | -6779 |
| MPO | 3220 | -6776 |
| MVP | 2998 | -2267 |
| NAPRT | 3205 | -6164 |
| NBEAL2 | 3020 | -4329 |
| NCKAP1L | 3360 | -6178 |
| NCSTN | 4254 | -3821 |
| NDUFC2 | 2451 | -4977 |
| NEU1 | 4167 | -3878 |
| NHLRC3 | 395 | 1682 |
| NIT2 | -4507 | -2140 |
| NME2 | 576 | -4319 |
| NPC2 | 2118 | -712 |
| ORMDL3 | -3550 | -2716 |
| OSCAR | 4186 | -4669 |
| OSTF1 | 3214 | 1667 |
| P2RX1 | 3829 | -6722 |
| PA2G4 | -1166 | -175 |
| PAFAH1B2 | 2931 | -1392 |
| PDAP1 | 2352 | -1208 |
| PDXK | 3939 | -5028 |
| PFKL | -977 | -5964 |
| PGAM1 | 4383 | -2347 |
| PGM1 | 2316 | -4799 |
| PGM2 | 4341 | -1959 |
| PKM | 4362 | -3076 |
| PLAC8 | 3838 | -4418 |
| PLAU | 1828 | -6512 |
| PLAUR | 3822 | -6237 |
| PLD1 | 4321 | -6058 |
| PLEKHO2 | 3605 | -3111 |
| PNP | 3818 | -4436 |
| PPIA | -2133 | 490 |
| PPIE | -3082 | 644 |
| PRCP | 3695 | 368 |
| PRDX6 | 4109 | 916 |
| PRKCD | 4154 | 584 |
| PRTN3 | 2825 | -6448 |
| PSAP | 3061 | -4192 |
| PSEN1 | 3540 | -3407 |
| PSMA2 | 2052 | 1205 |
| PSMA5 | -1869 | 592 |
| PSMB1 | 1131 | -1179 |
| PSMB7 | 3856 | -2038 |
| PSMC3 | 624 | -4615 |
| PSMD1 | 3112 | 1660 |
| PSMD11 | 2532 | -2152 |
| PSMD12 | 2710 | 1314 |
| PSMD13 | 2376 | 1328 |
| PSMD14 | 836 | -2484 |
| PSMD2 | 3204 | -85 |
| PSMD3 | 1696 | -4331 |
| PSMD6 | 3465 | -5488 |
| PSMD7 | 2383 | 7 |
| PTGES2 | -2198 | -1462 |
| PTPN6 | 2452 | -4586 |
| PTPRC | 706 | -1407 |
| PTPRJ | 3428 | 2365 |
| PTPRN2 | 1970 | 2235 |
| PYCARD | 3942 | -6598 |
| PYGB | 152 | -5617 |
| QPCT | 4331 | -6405 |
| QSOX1 | 4315 | -1087 |
| RAB10 | 4103 | -3437 |
| RAB14 | 3027 | 1334 |
| RAB18 | 3438 | -1995 |
| RAB24 | 2063 | -3725 |
| RAB27A | 3811 | -1181 |
| RAB37 | -4565 | -5384 |
| RAB3A | 3646 | -1080 |
| RAB3D | 4263 | -6515 |
| RAB4B | 1028 | 1318 |
| RAB5B | 2790 | -2055 |
| RAB5C | 3953 | -1152 |
| RAB6A | 3657 | -311 |
| RAB7A | 4002 | -5570 |
| RAC1 | 4031 | 971 |
| RAP1A | 3148 | 323 |
| RAP1B | 1058 | -1031 |
| RAP2B | -248 | -2291 |
| RHOA | 3753 | 1313 |
| RHOF | -4879 | 1911 |
| RHOG | 3858 | 860 |
| RNASET2 | 2360 | 2094 |
| ROCK1 | 3246 | -985 |
| S100A11 | 4118 | -1013 |
| S100P | 3758 | 1295 |
| SCAMP1 | 584 | -356 |
| SDCBP | 4324 | -2535 |
| SERPINB1 | 4382 | -4489 |
| SERPINB6 | 2324 | -5578 |
| SLC11A1 | 4243 | -4413 |
| SLC15A4 | 1288 | -5940 |
| SLC27A2 | -1137 | -6055 |
| SLC2A3 | 4160 | -4757 |
| SLC44A2 | 861 | 2003 |
| SLCO4C1 | 1061 | -1063 |
| SNAP23 | 3937 | -6016 |
| SNAP29 | 2615 | -4157 |
| SPTAN1 | -4344 | -1250 |
| SRP14 | 2573 | -848 |
| STBD1 | 2159 | -6441 |
| STK10 | -1159 | -3955 |
| STK11IP | 1224 | -3840 |
| STOM | 2795 | -3877 |
| SURF4 | 3001 | 1222 |
| SVIP | 642 | -4596 |
| TBC1D10C | -4609 | 2261 |
| TCIRG1 | 3087 | -5082 |
| TLR2 | 4206 | -6586 |
| TMBIM1 | 3776 | -1433 |
| TMC6 | -3874 | 2299 |
| TMEM179B | 140 | 276 |
| TMEM30A | 3589 | -1977 |
| TMEM63A | -3139 | -5444 |
| TNFRSF1B | 2421 | 2416 |
| TOLLIP | 3905 | -5037 |
| TOM1 | 4259 | -5118 |
| TRAPPC1 | 3441 | -3029 |
| TRPM2 | 4205 | -6600 |
| TSPAN14 | 2946 | 1366 |
| TUBB | -2209 | 1395 |
| TUBB4B | 3111 | 1856 |
| TXNDC5 | 122 | -5179 |
| TYROBP | 3270 | -6720 |
| UNC13D | 3311 | -6493 |
| VAMP8 | 1989 | -6050 |
| VAPA | 4169 | -5592 |
| VAT1 | 4302 | -3481 |
| VCL | 3157 | -5870 |
| VCP | 2902 | -2411 |
| XRCC5 | 2075 | -3770 |
| XRCC6 | -1335 | 376 |
| YPEL5 | 2788 | -1479 |
Immune System
| metric | value |
|---|---|
| setSize | 1142 |
| pMANOVA | 2.01e-30 |
| p.adjustMANOVA | 1.51e-29 |
| s.dist | 0.208 |
| s.RNA | 0.202 |
| s.meth | 0.0493 |
| p.RNA | 1.16e-28 |
| p.meth | 0.00686 |
| Gene | RNA | meth |
|---|---|---|
| CLTC | 4149 | 2477 |
| AGPAT2 | 4289 | 2250 |
| SOCS3 | 4399 | 2178 |
| SIAH2 | 3910 | 2185 |
| COTL1 | 3526 | 2411 |
| PTPRJ | 3428 | 2365 |
| CD53 | 3492 | 2243 |
| TLR5 | 4260 | 1823 |
| LCP1 | 3793 | 2024 |
| ICAM3 | 3443 | 2137 |
| SLA | 3335 | 2206 |
| CTSD | 4381 | 1642 |
| EIF4E3 | 3286 | 2181 |
| IL19 | 2820 | 2517 |
| ACTG1 | 3901 | 1793 |
| ATP6V1A | 4318 | 1580 |
| RNF123 | 2846 | 2363 |
| ATP6V0B | 3921 | 1604 |
| LAMTOR2 | 3287 | 1882 |
| MYH9 | 2789 | 2182 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| A1BG | 2170 | -3533 |
| AAAS | -2812 | 405 |
| AAMP | -1084 | -5298 |
| ABCE1 | -3946 | -1384 |
| ABI1 | 3018 | -1788 |
| ABI2 | -4048 | -5451 |
| ABL1 | 63 | -4891 |
| ABL2 | 1565 | 301 |
| ACAA1 | 3734 | 1410 |
| ACLY | 1961 | -5417 |
| ACTB | 4156 | -4515 |
| ACTG1 | 3901 | 1793 |
| ACTR10 | 3309 | -1291 |
| ACTR1A | 2965 | -1 |
| ACTR1B | -3828 | -3653 |
| ACTR2 | 3481 | -3374 |
| ACTR3 | 3448 | -2917 |
| ADAM10 | 4030 | 976 |
| ADAM17 | 3634 | 774 |
| ADAM8 | 2208 | -5902 |
| ADAR | -1029 | -263 |
| ADGRE5 | -769 | -5511 |
| AGA | -1396 | -2458 |
| AGL | -940 | -3188 |
| AGPAT2 | 4289 | 2250 |
| AHCYL1 | 2658 | -3553 |
| AIM2 | -522 | -3997 |
| AIP | -1061 | 1761 |
| AKT1 | 1234 | -1942 |
| AKT2 | 133 | -141 |
| ALAD | 3874 | -1369 |
| ALDOA | 4285 | -1349 |
| ALDOC | -1028 | -6226 |
| ALOX5 | 4150 | -6082 |
| AMPD3 | 3997 | -5620 |
| ANAPC1 | -4659 | 403 |
| ANAPC10 | -1520 | -6111 |
| ANAPC11 | 2490 | 344 |
| ANAPC13 | 941 | -1507 |
| ANAPC2 | -2390 | -1007 |
| ANAPC4 | -2075 | -1696 |
| ANAPC5 | -4080 | -2530 |
| ANAPC7 | -1573 | 1560 |
| ANO6 | 3597 | -3634 |
| AP1B1 | 3995 | -463 |
| AP1G1 | 1397 | 516 |
| AP1M1 | 2798 | -2408 |
| AP1S3 | -1681 | -5455 |
| AP2A1 | 2869 | -4887 |
| AP2M1 | 3936 | 20 |
| AP2S1 | 3581 | -3262 |
| APAF1 | 4158 | -2104 |
| APEH | 314 | 1724 |
| APP | 4249 | -5300 |
| APRT | -834 | -204 |
| AREL1 | 2666 | -139 |
| ARF1 | 4184 | -6686 |
| ARHGAP9 | 2545 | 2156 |
| ARIH1 | -679 | -323 |
| ARIH2 | -4739 | 846 |
| ARL8A | 3713 | -6230 |
| ARMC8 | 2620 | -1033 |
| ARPC1B | 4291 | -2022 |
| ARPC2 | 3191 | -3647 |
| ARPC3 | 3729 | -3767 |
| ARPC5 | 3968 | -3837 |
| ARSA | 1183 | -3099 |
| ARSB | 3290 | -5722 |
| ASAH1 | 3880 | 335 |
| ASB1 | 1105 | 1900 |
| ASB13 | 1106 | -5265 |
| ASB2 | -4671 | -2230 |
| ASB6 | -832 | -6098 |
| ASB7 | 2524 | -4653 |
| ASB8 | 1819 | 998 |
| ATAD3B | -3588 | -1948 |
| ATF1 | 2245 | -2565 |
| ATG12 | -247 | -111 |
| ATG5 | 429 | -2626 |
| ATG7 | 3647 | 569 |
| ATOX1 | 1562 | -5343 |
| ATP11A | 3801 | -5671 |
| ATP11B | 2429 | 1806 |
| ATP6V0A1 | 4375 | -5877 |
| ATP6V0A2 | -4811 | 689 |
| ATP6V0B | 3921 | 1604 |
| ATP6V0C | 4218 | -4697 |
| ATP6V0D1 | 4282 | -1003 |
| ATP6V0E1 | 3919 | -2865 |
| ATP6V0E2 | -4420 | -6625 |
| ATP6V1A | 4318 | 1580 |
| ATP6V1B2 | 4178 | -4232 |
| ATP6V1C1 | 3887 | 655 |
| ATP6V1D | 4174 | -1234 |
| ATP6V1E1 | 3588 | -3948 |
| ATP6V1F | 2338 | 1350 |
| ATP6V1G2 | -3312 | -3714 |
| ATP6V1H | 3607 | -1695 |
| ATP8A1 | -4599 | -250 |
| ATP8B4 | 2945 | 1090 |
| B2M | -2195 | -2389 |
| B4GALT1 | 1540 | -160 |
| BAIAP2 | -72 | 1977 |
| BATF | 2612 | 2070 |
| BCL10 | 2320 | -3261 |
| BCL2 | -1421 | 2361 |
| BCL2L1 | 3979 | 1306 |
| BCL2L11 | 3187 | 1781 |
| BCL6 | 4248 | -299 |
| BIN2 | 2264 | -2805 |
| BIRC2 | 1737 | -1862 |
| BIRC3 | -4159 | -2320 |
| BIRC5 | 1291 | -84 |
| BLMH | 980 | -515 |
| BRI3 | 4159 | -6229 |
| BRK1 | 2983 | 1970 |
| BRWD1 | -3183 | -3884 |
| BST2 | -2378 | -1970 |
| BTBD1 | 715 | -5321 |
| BTBD6 | -1584 | -136 |
| BTN2A1 | -2813 | -107 |
| BTN2A2 | -4532 | -893 |
| BTN3A1 | -4889 | 1435 |
| BTN3A2 | -4647 | 599 |
| BTN3A3 | -4877 | 2244 |
| BTRC | -1493 | -2427 |
| C3AR1 | 3573 | -6729 |
| C6orf120 | 2508 | 1218 |
| C8G | -4476 | 397 |
| CAB39 | 3728 | -2802 |
| CALM1 | -626 | -5019 |
| CALR | 2586 | -3753 |
| CAMK2D | -4581 | -2867 |
| CAMK2G | 601 | 2354 |
| CAND1 | -2041 | -421 |
| CANX | 2151 | -4839 |
| CAP1 | 3635 | -553 |
| CAPN1 | 3902 | -6119 |
| CAPZA1 | 3648 | 572 |
| CAPZA2 | 3920 | -36 |
| CAPZB | 3576 | -4065 |
| CARD11 | -4781 | 851 |
| CARD9 | 2767 | -6197 |
| CASP1 | 1501 | -1448 |
| CASP10 | -1032 | -6612 |
| CASP3 | -208 | -2764 |
| CASP4 | 2359 | -5184 |
| CASP8 | -4285 | 387 |
| CASP9 | 3366 | -234 |
| CAT | 4214 | -3922 |
| CBL | 3241 | 1456 |
| CBLB | -4856 | -840 |
| CCND1 | -2214 | -6213 |
| CCNF | -3202 | -4258 |
| CCR1 | 4074 | -6480 |
| CCT2 | -3002 | -727 |
| CCT8 | 2708 | -1245 |
| CD247 | -4880 | 2098 |
| CD274 | -2456 | -296 |
| CD300A | -641 | -6466 |
| CD3D | -4327 | 2493 |
| CD3E | -4258 | 2442 |
| CD4 | -1648 | -6372 |
| CD44 | 3760 | 266 |
| CD46 | 2321 | -4098 |
| CD47 | -4754 | -114 |
| CD53 | 3492 | 2243 |
| CD55 | 4229 | -3923 |
| CD58 | 2766 | -3228 |
| CD59 | 2326 | -6024 |
| CD63 | 4308 | -1017 |
| CD74 | -4340 | -4283 |
| CD79B | -2407 | -6685 |
| CD81 | -3185 | -4830 |
| CD96 | -4743 | 2283 |
| CDC16 | -1877 | -4152 |
| CDC20 | 1401 | 116 |
| CDC23 | -4259 | -707 |
| CDC34 | 3927 | -2454 |
| CDC42 | 3268 | -2719 |
| CDK13 | -2814 | -700 |
| CDKN1A | 1646 | -3540 |
| CDKN1B | -2723 | -862 |
| CEACAM1 | 3825 | -5827 |
| CEBPD | 4044 | -5142 |
| CENPE | 98 | -4165 |
| CEP290 | -3161 | -2056 |
| CFL1 | 3683 | 912 |
| CHUK | 3543 | 1343 |
| CISH | 1836 | 1748 |
| CKAP4 | 4355 | -6717 |
| CLEC2B | -3043 | -4871 |
| CLTA | 3788 | -5077 |
| CLTC | 4149 | 2477 |
| CMTM6 | 3495 | -3483 |
| CNN2 | 2764 | 1735 |
| CNPY3 | 3416 | -3161 |
| COMMD3 | -426 | -6772 |
| COMMD9 | 3544 | -4811 |
| COPB1 | 3154 | -1329 |
| COTL1 | 3526 | 2411 |
| CPNE1 | -1012 | 1274 |
| CPNE3 | 2335 | -2088 |
| CPPED1 | 3772 | -3919 |
| CRCP | 1795 | -577 |
| CREB1 | -430 | -672 |
| CREBBP | 1153 | -5804 |
| CREG1 | 4403 | -5637 |
| CRK | 4091 | -4581 |
| CRKL | 1387 | -906 |
| CSF1 | -622 | -5924 |
| CSK | 1990 | 862 |
| CSNK2B | 1389 | -998 |
| CSTB | 2911 | -2676 |
| CTF1 | 1521 | -5738 |
| CTLA4 | -3751 | 2506 |
| CTNNB1 | 2626 | -1691 |
| CTSA | 4412 | -4847 |
| CTSB | 4350 | -4209 |
| CTSC | 739 | 1561 |
| CTSD | 4381 | 1642 |
| CTSL | 1504 | -6671 |
| CTSO | -4305 | 1113 |
| CTSS | 3785 | -2958 |
| CTSV | -910 | -5834 |
| CTSZ | 4137 | -6765 |
| CUL1 | -4281 | -5146 |
| CUL2 | 805 | -1212 |
| CUL3 | 2861 | 2054 |
| CUL5 | 265 | -3077 |
| CUL7 | -995 | -2524 |
| CXCL2 | 2093 | -6755 |
| CYB5R3 | 4090 | -1540 |
| CYBA | 2922 | 1006 |
| CYFIP1 | 4295 | -6630 |
| CYFIP2 | -3754 | 2232 |
| CYLD | -3240 | 1406 |
| CYSTM1 | 4193 | -5233 |
| DAPP1 | 2125 | 279 |
| DBNL | 3411 | -3713 |
| DCTN2 | 4235 | -6011 |
| DCTN3 | 2396 | -4272 |
| DCTN4 | 3796 | -2073 |
| DCTN5 | -1222 | -5100 |
| DCTN6 | 3145 | 819 |
| DDX41 | 1154 | -118 |
| DDX58 | -4651 | -1002 |
| DEGS1 | 2496 | -193 |
| DERA | 3866 | -756 |
| DET1 | -3172 | 978 |
| DGAT1 | 2033 | -6115 |
| DHX36 | -1599 | 2251 |
| DHX58 | -4588 | -5666 |
| DHX9 | 322 | 871 |
| DIAPH1 | -283 | 1033 |
| DNAJC13 | 3719 | -4825 |
| DNAJC3 | 3828 | -2353 |
| DNAJC5 | 3964 | -5119 |
| DNM1 | 1225 | -5619 |
| DNM2 | 2448 | 738 |
| DPP7 | -1381 | -1037 |
| DSN1 | -3971 | 369 |
| DTX4 | 2486 | 1530 |
| DUSP3 | 4305 | -1798 |
| DUSP4 | -1957 | -3176 |
| DUSP6 | 1570 | -6763 |
| DUSP7 | -960 | -1322 |
| DYNC1H1 | -2492 | 1504 |
| DYNC1I2 | 3399 | -4337 |
| DYNC1LI1 | 2930 | -2912 |
| DYNC1LI2 | 1527 | -5470 |
| DYNLL1 | 2378 | -3319 |
| DYNLL2 | -1189 | 214 |
| DYNLT1 | 1622 | 1458 |
| DZIP3 | -4106 | -5113 |
| ECSIT | 1839 | -4938 |
| EDARADD | -4064 | 1906 |
| EEA1 | 1708 | -711 |
| EEF1A1 | -1549 | 720 |
| EEF2 | 90 | 2127 |
| EGR1 | 1023 | -163 |
| EIF2AK2 | -3128 | -3645 |
| EIF4A1 | 3303 | -3762 |
| EIF4A2 | -4175 | 836 |
| EIF4A3 | 3132 | -3850 |
| EIF4E | 1789 | 1536 |
| EIF4E2 | 3181 | 1473 |
| EIF4E3 | 3286 | 2181 |
| EIF4G1 | 3585 | 746 |
| EIF4G2 | 2920 | -3101 |
| EIF4G3 | 3804 | -3868 |
| ELMO1 | 2547 | -2714 |
| ELMO2 | 1591 | 1326 |
| ENPP4 | -3342 | -1178 |
| EP300 | 2471 | -4509 |
| ERAP1 | -2372 | -1887 |
| ERAP2 | -1627 | -1261 |
| ERP44 | 2912 | 1942 |
| EVL | -4808 | 2303 |
| FABP5 | 2411 | -3534 |
| FADD | 2211 | -6328 |
| FAF2 | 2168 | -4965 |
| FBXL12 | -407 | 292 |
| FBXL14 | -1899 | 2358 |
| FBXL15 | 1641 | -4502 |
| FBXL16 | -2077 | -4011 |
| FBXL18 | 1098 | -5248 |
| FBXL19 | 3931 | -6239 |
| FBXL20 | 1804 | -993 |
| FBXL22 | -3179 | 562 |
| FBXL3 | 318 | -4101 |
| FBXL4 | 2136 | -5130 |
| FBXL5 | 4370 | -6189 |
| FBXL8 | 1413 | -479 |
| FBXO11 | 2793 | -500 |
| FBXO15 | -394 | 647 |
| FBXO21 | -3979 | -933 |
| FBXO22 | -1105 | 1132 |
| FBXO30 | 1733 | -609 |
| FBXO31 | -4652 | 480 |
| FBXO32 | -3875 | -1875 |
| FBXO4 | -4600 | -4056 |
| FBXO6 | -687 | 234 |
| FBXO7 | 3250 | -3059 |
| FBXO9 | 4374 | -3674 |
| FBXW11 | 2510 | -6747 |
| FBXW2 | 2712 | -3711 |
| FBXW4 | -4543 | 1993 |
| FBXW5 | 76 | -194 |
| FBXW7 | -2055 | -5428 |
| FBXW8 | -3557 | -2504 |
| FGR | 3853 | -5292 |
| FKBP1A | 4177 | -4465 |
| FLNB | 536 | 1550 |
| FLT3LG | -3495 | 1573 |
| FOS | 2120 | 2149 |
| FOXO1 | -3290 | -5036 |
| FOXO3 | 3966 | 711 |
| FTH1 | 1827 | -521 |
| FTL | 3957 | -4621 |
| FUCA1 | 3203 | -5579 |
| FUCA2 | 3743 | -427 |
| FYN | -4495 | 1957 |
| FZR1 | -670 | -758 |
| GAA | 3545 | -3801 |
| GAB2 | 3629 | -6153 |
| GALNS | 3034 | -854 |
| GAN | -440 | -2479 |
| GATA3 | -4799 | 1861 |
| GBP3 | -3069 | -3362 |
| GCA | 4384 | -5597 |
| GDI2 | 3138 | -587 |
| GGH | 2515 | -2788 |
| GHDC | 1470 | -5520 |
| GLB1 | 3992 | 1368 |
| GLIPR1 | 3403 | -2351 |
| GLMN | -4133 | 2117 |
| GM2A | 4180 | -825 |
| GMFG | 3717 | -2699 |
| GNS | 4348 | -571 |
| GOLGA7 | 1429 | -2970 |
| GPI | 2558 | -2211 |
| GRAP2 | 1736 | -5763 |
| GRB10 | 4386 | -70 |
| GRB2 | 4320 | -2295 |
| GRN | 4323 | -4414 |
| GSDMD | 614 | -3378 |
| GSTO1 | 4196 | -170 |
| GSTP1 | 35 | -5415 |
| GUSB | 3389 | -4967 |
| GYG1 | 4157 | -5541 |
| GZMM | -4597 | 2516 |
| HACE1 | -1806 | -6052 |
| HCST | -1569 | 1737 |
| HEBP2 | 3803 | -1822 |
| HECTD1 | -744 | -2953 |
| HECTD3 | 377 | -6086 |
| HERC1 | -3213 | -1142 |
| HERC3 | 319 | -2583 |
| HERC4 | 1825 | -2430 |
| HERC5 | -4820 | -6136 |
| HEXB | 4022 | -5777 |
| HGSNAT | 583 | 2126 |
| HIF1A | 3219 | -3349 |
| HLA-A | -771 | -5991 |
| HLA-B | 205 | 1015 |
| HLA-C | 321 | -25 |
| HLA-DMA | -3490 | -6628 |
| HLA-E | -1317 | -2213 |
| HLA-F | -4165 | 1671 |
| HLA-H | -1158 | -101 |
| HMGB1 | -86 | -1263 |
| HMOX2 | -4583 | 2130 |
| HNRNPA2B1 | 1133 | -2665 |
| HNRNPF | 1366 | -58 |
| HRAS | -1008 | -4780 |
| HSP90AA1 | 411 | -781 |
| HSP90AB1 | -2171 | -5745 |
| HSP90B1 | 647 | -1371 |
| HSPA1A | 3613 | -3825 |
| HSPA1B | 2669 | -513 |
| HSPA9 | -3436 | -200 |
| HVCN1 | 1834 | -217 |
| ICAM1 | 2796 | -5333 |
| ICAM2 | -4698 | 427 |
| ICAM3 | 3443 | 2137 |
| ICAM5 | 3528 | -5930 |
| ICOSLG | -2168 | -4532 |
| IDH1 | 4409 | -2333 |
| IFI30 | 3367 | -6228 |
| IFI35 | -1735 | -1569 |
| IFI6 | -4620 | -2830 |
| IFIH1 | -4282 | -4856 |
| IFIT1 | -4864 | -4377 |
| IFIT2 | -4749 | -5574 |
| IFIT3 | -4705 | -2035 |
| IFIT5 | -4254 | -90 |
| IFITM1 | -1947 | 2403 |
| IFNAR1 | 3813 | -490 |
| IFNAR2 | 2778 | -3573 |
| IFNGR1 | 4301 | 310 |
| IFNGR2 | 4279 | -6331 |
| IGF2R | 3062 | -5512 |
| IKBKB | -1640 | -3894 |
| IKBKE | 1750 | 2086 |
| IL10RA | -3866 | 1263 |
| IL10RB | 4239 | -6138 |
| IL12A | -2552 | -5748 |
| IL12RB1 | -4755 | -1444 |
| IL12RB2 | -4683 | -5603 |
| IL15 | -1531 | -5098 |
| IL15RA | 826 | -3679 |
| IL16 | -3409 | 656 |
| IL17C | -2074 | -1115 |
| IL17RA | 4257 | -3604 |
| IL17RC | 55 | -1157 |
| IL18BP | -3851 | -5936 |
| IL18R1 | 1399 | 475 |
| IL19 | 2820 | 2517 |
| IL1RAP | 3063 | -456 |
| IL21R | -4834 | 401 |
| IL23A | -3838 | -6478 |
| IL27RA | 1165 | -1230 |
| IL2RA | -2295 | -6462 |
| IL2RB | -4882 | 2472 |
| IL32 | -3617 | 2512 |
| IL4R | 3174 | -4452 |
| IL6R | 3645 | -6410 |
| IL6ST | 1415 | 1094 |
| ILF2 | -597 | -3803 |
| IMPDH1 | 4313 | -750 |
| IMPDH2 | -3507 | 446 |
| INPP5D | -1207 | -3735 |
| INPPL1 | 4166 | -2224 |
| IP6K2 | -3901 | -878 |
| IQGAP1 | 3661 | 1271 |
| IQGAP2 | 2738 | -246 |
| IRAK2 | -3327 | -1457 |
| IRAK3 | 4208 | -6295 |
| IRF1 | -2866 | 1887 |
| IRF2 | 2640 | -2044 |
| IRF3 | -2870 | 542 |
| IRF4 | -3062 | 1782 |
| IRF5 | 2684 | -6572 |
| IRF7 | -2922 | 1622 |
| IRF9 | -4174 | -4118 |
| IRS1 | 533 | -4060 |
| IRS2 | 3903 | -5410 |
| ISG15 | -4701 | 1894 |
| ISG20 | -4455 | 2340 |
| IST1 | 2328 | -3896 |
| ITCH | 407 | -1366 |
| ITGA4 | -4122 | 1419 |
| ITGAL | -4012 | 2268 |
| ITGAV | 2457 | -5201 |
| ITGB2 | 4114 | 1322 |
| ITGB7 | -4797 | -6402 |
| ITK | -4214 | -6507 |
| ITPR1 | -2478 | -3278 |
| ITPR2 | 2315 | -6107 |
| ITPR3 | -3717 | -3427 |
| JAK1 | -4072 | -1022 |
| JAK2 | 857 | -1751 |
| JUN | 1286 | 69 |
| JUNB | 2850 | -3031 |
| KBTBD6 | 870 | 327 |
| KBTBD7 | 2608 | -1326 |
| KBTBD8 | -1262 | -4094 |
| KCMF1 | 3480 | -3080 |
| KCNAB2 | -31 | -6014 |
| KCTD6 | 1579 | 886 |
| KCTD7 | -4415 | -602 |
| KEAP1 | 1826 | -2872 |
| KIF11 | 250 | -4751 |
| KIF15 | -968 | -563 |
| KIF18A | -823 | -2125 |
| KIF20A | 1931 | -231 |
| KIF22 | -4887 | -1801 |
| KIF23 | 2143 | -3340 |
| KIF2A | -340 | 1788 |
| KIF2C | 229 | -1625 |
| KIF3A | -4667 | -2118 |
| KIF3B | 1292 | -2584 |
| KIF3C | 3745 | -5135 |
| KIF5B | 3711 | -3520 |
| KIFAP3 | -2906 | 1836 |
| KLC1 | 2149 | -1283 |
| KLC2 | -3106 | -5681 |
| KLC4 | -2808 | -4132 |
| KLHL11 | -1956 | 186 |
| KLHL2 | 4247 | -4276 |
| KLHL20 | -4381 | -2781 |
| KLHL21 | 1909 | -1243 |
| KLHL22 | -4331 | -899 |
| KLHL25 | -3912 | -464 |
| KLHL5 | 1936 | -4208 |
| KPNA1 | 400 | -2889 |
| KPNA2 | -2190 | -874 |
| KPNA3 | 295 | -897 |
| KPNA4 | 1858 | 1716 |
| KPNA5 | -4625 | -572 |
| KPNB1 | 776 | -2176 |
| KRAS | 1276 | 440 |
| LAIR1 | 3084 | -6275 |
| LAMP1 | 3329 | -376 |
| LAMTOR1 | 4371 | -5950 |
| LAMTOR2 | 3287 | 1882 |
| LAMTOR3 | 3292 | 321 |
| LAT2 | 4033 | -5840 |
| LCK | -4596 | 2489 |
| LCP1 | 3793 | 2024 |
| LCP2 | -363 | 1588 |
| LGALS9 | 979 | -6589 |
| LGMN | -1401 | 313 |
| LIMK1 | 1730 | -3787 |
| LMNB1 | 4342 | -942 |
| LMO7 | -3402 | 2419 |
| LNPEP | -3357 | -478 |
| LONRF1 | 1658 | -187 |
| LPCAT1 | -2399 | 1540 |
| LRR1 | -2482 | 1362 |
| LRRC41 | 3257 | 404 |
| LRRFIP1 | 2568 | -1040 |
| LRSAM1 | 1798 | -530 |
| LTA | -3469 | 2525 |
| LTA4H | 4292 | -972 |
| LTB | -2823 | 1685 |
| LTN1 | -781 | 2476 |
| MALT1 | -4051 | -2968 |
| MAN2B1 | 2897 | -6345 |
| MANBA | 3188 | 1807 |
| MAP2K1 | 4183 | -698 |
| MAP2K3 | 4006 | -2657 |
| MAP2K4 | 2891 | -5363 |
| MAP2K6 | 4082 | -1130 |
| MAP2K7 | 514 | -3915 |
| MAP3K1 | 1942 | -176 |
| MAP3K14 | -4512 | -2542 |
| MAP3K3 | 3850 | 64 |
| MAP3K7 | 761 | -2089 |
| MAP3K8 | 2489 | 1442 |
| MAPK1 | 3249 | 1865 |
| MAPK14 | 4207 | -3529 |
| MAPK3 | 4121 | -2448 |
| MAPK7 | -412 | -1630 |
| MAPK8 | -3265 | 6 |
| MAPK9 | -2259 | 872 |
| MAPKAP1 | 1911 | 1057 |
| MAPKAPK2 | 1428 | 2012 |
| MAPKAPK3 | 3794 | -4540 |
| MAVS | 3048 | -4500 |
| MEF2A | 3571 | -2822 |
| MEX3C | -4774 | -2068 |
| MGRN1 | 2290 | -6360 |
| MICA | -1592 | -2075 |
| MICB | 749 | 922 |
| MIF | -1146 | -2943 |
| MKRN1 | 4045 | -2133 |
| MLEC | 737 | 953 |
| MLST8 | 117 | 287 |
| MMP25 | 3875 | 1010 |
| MNDA | 4303 | -6779 |
| MPO | 3220 | -6776 |
| MRC2 | -53 | -6280 |
| MT2A | -2224 | 1556 |
| MTAP | -1778 | -5878 |
| MTOR | -3429 | -1813 |
| MUC1 | 2718 | -5557 |
| MUC12 | -3930 | -5807 |
| MUC5B | -1389 | 2353 |
| MVP | 2998 | -2267 |
| MX1 | -4769 | -5375 |
| MX2 | -1727 | -1978 |
| MYD88 | 3649 | -1927 |
| MYH9 | 2789 | 2182 |
| MYLIP | -1191 | -681 |
| MYO9B | 2637 | 687 |
| NAPRT | 3205 | -6164 |
| NBEAL2 | 3020 | -4329 |
| NCF4 | 4298 | -6732 |
| NCK1 | -4361 | -1408 |
| NCKAP1L | 3360 | -6178 |
| NCKIPSD | 97 | -4332 |
| NCSTN | 4254 | -3821 |
| NDC1 | -4789 | -5228 |
| NDUFC2 | 2451 | -4977 |
| NEDD4 | 2511 | -5611 |
| NEDD4L | 3485 | -5066 |
| NEU1 | 4167 | -3878 |
| NF2 | -2034 | -2754 |
| NFATC1 | -3145 | 2372 |
| NFATC2 | -4851 | 2414 |
| NFATC3 | -4790 | 92 |
| NFKB2 | -367 | 388 |
| NFKBIA | 2851 | 1159 |
| NFKBIB | -48 | -3368 |
| NFKBIE | -1637 | 1607 |
| NHLRC3 | 395 | 1682 |
| NIT2 | -4507 | -2140 |
| NKIRAS1 | 116 | -3490 |
| NKIRAS2 | 4346 | -5039 |
| NLRC5 | -3726 | 1646 |
| NLRP1 | -1972 | -5049 |
| NLRP3 | 4089 | -6357 |
| NLRX1 | 3451 | -2858 |
| NME2 | 576 | -4319 |
| NOD1 | -4837 | -5170 |
| NOD2 | 3833 | 1528 |
| NOS3 | -620 | -1770 |
| NPC2 | 2118 | -712 |
| NUP107 | -3782 | -1197 |
| NUP133 | -2528 | 112 |
| NUP153 | -1967 | 834 |
| NUP155 | -3676 | -4352 |
| NUP160 | -3847 | 763 |
| NUP188 | -4466 | -847 |
| NUP205 | -4274 | 826 |
| NUP210 | -3943 | 910 |
| NUP214 | 3517 | 1119 |
| NUP35 | -3878 | -321 |
| NUP37 | 998 | -1886 |
| NUP43 | -3314 | 1617 |
| NUP50 | 1650 | 1760 |
| NUP54 | -2855 | -2767 |
| NUP62 | 242 | -980 |
| NUP85 | -912 | 317 |
| NUP88 | -4326 | -128 |
| NUP93 | -4463 | -3462 |
| NUP98 | 1012 | 315 |
| OAS1 | -3339 | -5215 |
| OAS2 | -4765 | 2093 |
| OAS3 | -4798 | -5833 |
| OASL | -4007 | -2933 |
| ORAI1 | -2269 | -4764 |
| ORAI2 | 2405 | -4356 |
| ORMDL3 | -3550 | -2716 |
| OSCAR | 4186 | -4669 |
| OSM | 3426 | -3652 |
| OSTF1 | 3214 | 1667 |
| P2RX1 | 3829 | -6722 |
| P4HB | 3831 | -1549 |
| PA2G4 | -1166 | -175 |
| PAFAH1B2 | 2931 | -1392 |
| PAG1 | 2019 | 262 |
| PAK1 | 3703 | -3995 |
| PAK2 | 3682 | -3961 |
| PANX1 | 2552 | 1595 |
| PCBP2 | 2027 | 132 |
| PDAP1 | 2352 | -1208 |
| PDCD4 | -4586 | 1941 |
| PDE12 | -1960 | 1354 |
| PDIA3 | 1451 | 1466 |
| PDPK1 | 2474 | 167 |
| PDXK | 3939 | -5028 |
| PELI1 | 2800 | -3839 |
| PELI2 | 3750 | -2561 |
| PELI3 | 3383 | -4323 |
| PFKL | -977 | -5964 |
| PGAM1 | 4383 | -2347 |
| PGM1 | 2316 | -4799 |
| PGM2 | 4341 | -1959 |
| PIAS1 | 3175 | -2534 |
| PIK3AP1 | 3445 | -4753 |
| PIK3CA | 1703 | -1445 |
| PIK3CD | 2422 | 2189 |
| PIK3R1 | -3307 | 2310 |
| PIK3R2 | 1887 | -1223 |
| PIK3R3 | -4692 | -22 |
| PIK3R4 | -1215 | -3425 |
| PILRB | -4277 | 19 |
| PIM1 | 3377 | -5227 |
| PIN1 | -955 | -1656 |
| PITPNA | 2860 | -2752 |
| PJA2 | 3244 | 662 |
| PKM | 4362 | -3076 |
| PLA2G6 | -4758 | -3132 |
| PLAC8 | 3838 | -4418 |
| PLAU | 1828 | -6512 |
| PLAUR | 3822 | -6237 |
| PLCG1 | -4158 | -3541 |
| PLCG2 | 1884 | -2562 |
| PLD1 | 4321 | -6058 |
| PLD3 | 3177 | 1541 |
| PLEKHO2 | 3605 | -3111 |
| PML | -2938 | 549 |
| PNP | 3818 | -4436 |
| POLR1C | -4039 | -2688 |
| POLR1D | 2715 | -2500 |
| POLR2E | 3283 | -1584 |
| POLR2F | 1692 | -4483 |
| POLR2H | -882 | 1944 |
| POLR2K | -537 | -2424 |
| POLR3A | -2354 | 2213 |
| POLR3C | -2396 | 509 |
| POLR3D | -4557 | 1264 |
| POLR3E | -4318 | -673 |
| POLR3F | -1579 | -5523 |
| POLR3G | -1645 | 1201 |
| POLR3GL | -2424 | -6348 |
| POLR3H | -3719 | -510 |
| POLR3K | -737 | 1383 |
| POM121 | -2766 | -1787 |
| POM121C | -2305 | -4315 |
| POU2F1 | 470 | 733 |
| PPIA | -2133 | 490 |
| PPIE | -3082 | 644 |
| PPM1B | 2218 | 1592 |
| PPP2CA | 3707 | 300 |
| PPP2CB | 3381 | 1797 |
| PPP2R1B | -84 | -2554 |
| PPP2R5A | 2347 | 381 |
| PPP2R5B | 2831 | -6343 |
| PPP2R5C | -4242 | 2376 |
| PPP2R5D | 771 | -4349 |
| PPP2R5E | -217 | -2288 |
| PPP3CA | 2522 | -2165 |
| PPP3CB | 2968 | 517 |
| PPP3R1 | 3675 | -3276 |
| PRCP | 3695 | 368 |
| PRDX6 | 4109 | 916 |
| PRKACA | 4378 | -6032 |
| PRKACB | -4656 | 455 |
| PRKCB | 3029 | -4518 |
| PRKCD | 4154 | 584 |
| PRKCE | -2638 | -5632 |
| PRKCQ | -4762 | 1372 |
| PRKCSH | 1991 | -3007 |
| PRKDC | -3668 | 1316 |
| PRR5 | -4676 | -1591 |
| PRTN3 | 2825 | -6448 |
| PSAP | 3061 | -4192 |
| PSEN1 | 3540 | -3407 |
| PSMA1 | 3158 | -1782 |
| PSMA2 | 2052 | 1205 |
| PSMA3 | -1612 | -2824 |
| PSMA5 | -1869 | 592 |
| PSMA6 | 2386 | -1838 |
| PSMA7 | 3028 | 1752 |
| PSMB1 | 1131 | -1179 |
| PSMB10 | -1758 | -4718 |
| PSMB2 | 1439 | 2355 |
| PSMB3 | 3076 | -2678 |
| PSMB5 | 3630 | -4604 |
| PSMB6 | 2854 | -3576 |
| PSMB7 | 3856 | -2038 |
| PSMB8 | -921 | 1189 |
| PSMB9 | -4276 | -1453 |
| PSMC1 | 2977 | -5705 |
| PSMC3 | 624 | -4615 |
| PSMC4 | -3133 | 1003 |
| PSMC5 | -287 | -3263 |
| PSMC6 | 2757 | -5508 |
| PSMD1 | 3112 | 1660 |
| PSMD11 | 2532 | -2152 |
| PSMD12 | 2710 | 1314 |
| PSMD13 | 2376 | 1328 |
| PSMD14 | 836 | -2484 |
| PSMD2 | 3204 | -85 |
| PSMD3 | 1696 | -4331 |
| PSMD4 | 3806 | -4683 |
| PSMD6 | 3465 | -5488 |
| PSMD7 | 2383 | 7 |
| PSMD8 | 2270 | -3290 |
| PSMD9 | 3321 | -2041 |
| PSME1 | -3548 | -2343 |
| PSME2 | -3731 | -2364 |
| PSME3 | 3715 | 1116 |
| PSME4 | -1884 | -3380 |
| PSMF1 | 2775 | -4867 |
| PSTPIP1 | 3462 | 1135 |
| PTEN | 3844 | -1100 |
| PTGES2 | -2198 | -1462 |
| PTK2 | 1629 | 920 |
| PTK2B | 3527 | 40 |
| PTPN1 | 2254 | 2074 |
| PTPN11 | 2038 | -2302 |
| PTPN12 | 3660 | -1077 |
| PTPN13 | -3534 | -6489 |
| PTPN18 | 2482 | 693 |
| PTPN2 | 3316 | -3701 |
| PTPN22 | -379 | -1114 |
| PTPN23 | -372 | -3227 |
| PTPN4 | -4818 | -3156 |
| PTPN6 | 2452 | -4586 |
| PTPN7 | -4023 | -1888 |
| PTPN9 | 2799 | -1265 |
| PTPRC | 706 | -1407 |
| PTPRJ | 3428 | 2365 |
| PTPRN2 | 1970 | 2235 |
| PYCARD | 3942 | -6598 |
| PYGB | 152 | -5617 |
| QPCT | 4331 | -6405 |
| QSOX1 | 4315 | -1087 |
| RAB10 | 4103 | -3437 |
| RAB14 | 3027 | 1334 |
| RAB18 | 3438 | -1995 |
| RAB24 | 2063 | -3725 |
| RAB27A | 3811 | -1181 |
| RAB37 | -4565 | -5384 |
| RAB3A | 3646 | -1080 |
| RAB3D | 4263 | -6515 |
| RAB4B | 1028 | 1318 |
| RAB5B | 2790 | -2055 |
| RAB5C | 3953 | -1152 |
| RAB6A | 3657 | -311 |
| RAB7A | 4002 | -5570 |
| RAC1 | 4031 | 971 |
| RAC2 | 1962 | -868 |
| RACGAP1 | 916 | 1472 |
| RAE1 | 1963 | -39 |
| RAF1 | 3488 | -314 |
| RALA | 864 | -262 |
| RANBP2 | -273 | -4704 |
| RAP1A | 3148 | 323 |
| RAP1B | 1058 | -1031 |
| RAP2B | -248 | -2291 |
| RAPGEF1 | -3458 | 1868 |
| RASGRP1 | -4668 | 2119 |
| RASGRP2 | -2873 | 1508 |
| RASGRP3 | -3259 | -2004 |
| RBBP6 | -354 | -2825 |
| RBCK1 | 694 | -1357 |
| RBSN | -1363 | -2813 |
| RBX1 | 1368 | -3241 |
| RCHY1 | 2606 | 2124 |
| REL | 1202 | -3846 |
| RELA | -542 | 2085 |
| RELB | 1285 | -5206 |
| RHOA | 3753 | 1313 |
| RHOF | -4879 | 1911 |
| RHOG | 3858 | 860 |
| RICTOR | -3383 | 1651 |
| RILP | 3789 | -4831 |
| RIPK3 | 1497 | -370 |
| RNASEL | 3436 | 326 |
| RNASET2 | 2360 | 2094 |
| RNF111 | 2267 | 779 |
| RNF114 | 969 | -3694 |
| RNF115 | -3433 | 1631 |
| RNF123 | 2846 | 2363 |
| RNF125 | -4197 | -1762 |
| RNF126 | -3842 | 1899 |
| RNF135 | 3897 | -6458 |
| RNF138 | 1584 | 1102 |
| RNF14 | 1575 | -1169 |
| RNF144B | 3778 | -5953 |
| RNF19A | -3658 | 1813 |
| RNF19B | 2827 | 380 |
| RNF213 | -4630 | 2228 |
| RNF216 | -3839 | 201 |
| RNF220 | -1962 | 1733 |
| RNF25 | -2343 | -1189 |
| RNF34 | -1902 | 42 |
| RNF4 | -4370 | -151 |
| RNF41 | 3797 | 109 |
| RNF6 | 1372 | -2084 |
| RNF7 | 3510 | -1943 |
| ROCK1 | 3246 | -985 |
| RORA | -4672 | 2287 |
| RPLP0 | -320 | -185 |
| RPS27A | -2201 | -2138 |
| RPS6KA1 | 3372 | -6629 |
| RPS6KA2 | 1006 | -1784 |
| RPS6KA5 | -4445 | -514 |
| S100A11 | 4118 | -1013 |
| S100P | 3758 | 1295 |
| S1PR1 | -3180 | 2436 |
| SAMHD1 | 2619 | -2016 |
| SAR1B | 2676 | 489 |
| SARM1 | -4766 | -5412 |
| SCAMP1 | 584 | -356 |
| SDCBP | 4324 | -2535 |
| SEC13 | 2266 | -3749 |
| SEC23A | 3162 | -5141 |
| SEC24A | 3350 | 61 |
| SEC24B | 1233 | -5505 |
| SEC24C | -768 | 805 |
| SEC24D | 3637 | -3966 |
| SEC31A | 346 | -4985 |
| SEC61A1 | 2654 | -592 |
| SEC61A2 | -3985 | 917 |
| SEC61B | 2971 | 33 |
| SEC61G | 1745 | 1052 |
| SEH1L | -1875 | -1615 |
| SERPINB1 | 4382 | -4489 |
| SERPINB6 | 2324 | -5578 |
| SH2B1 | -2928 | -1068 |
| SH2B3 | 1358 | 1699 |
| SHC1 | 1472 | -2954 |
| SIAH1 | -897 | -6217 |
| SIAH2 | 3910 | 2185 |
| SIGIRR | -3958 | 290 |
| SIKE1 | -2255 | -1187 |
| SIPA1 | 1408 | -2006 |
| SKP1 | 1536 | -2290 |
| SKP2 | -2759 | -1566 |
| SLA | 3335 | 2206 |
| SLA2 | -3338 | 960 |
| SLAMF6 | -4801 | 2420 |
| SLC11A1 | 4243 | -4413 |
| SLC15A4 | 1288 | -5940 |
| SLC27A2 | -1137 | -6055 |
| SLC2A3 | 4160 | -4757 |
| SLC44A2 | 861 | 2003 |
| SLCO4C1 | 1061 | -1063 |
| SMAD3 | -4538 | -4628 |
| SMARCA4 | 1758 | 2317 |
| SMURF1 | -780 | 1321 |
| SMURF2 | -3735 | -3048 |
| SNAP23 | 3937 | -6016 |
| SNAP29 | 2615 | -4157 |
| SNRPA1 | -3561 | -3336 |
| SOCS1 | 1375 | -2999 |
| SOCS2 | -757 | 378 |
| SOCS3 | 4399 | 2178 |
| SOCS5 | 1047 | -4583 |
| SOD1 | -1475 | -1019 |
| SOD2 | 1587 | 573 |
| SOS1 | -1748 | -6775 |
| SOS2 | 3740 | -4105 |
| SP100 | 1552 | -769 |
| SPSB1 | 756 | -3865 |
| SPTAN1 | -4344 | -1250 |
| SQSTM1 | 1438 | -952 |
| SRC | -2999 | -4427 |
| SRP14 | 2573 | -848 |
| STAT1 | -4529 | 2195 |
| STAT2 | -3894 | -3295 |
| STAT3 | 3628 | -3606 |
| STAT4 | -4875 | -425 |
| STAT5A | 2943 | -6427 |
| STAT5B | 2923 | -3446 |
| STAT6 | 2340 | -3911 |
| STBD1 | 2159 | -6441 |
| STIM1 | 1369 | 2500 |
| STK10 | -1159 | -3955 |
| STK11IP | 1224 | -3840 |
| STOM | 2795 | -3877 |
| STUB1 | -330 | -2168 |
| STX1A | -1213 | -2461 |
| STX3 | 3861 | -1755 |
| STX4 | 189 | -6001 |
| STXBP2 | 4170 | -6352 |
| SUGT1 | 475 | 594 |
| SUMO1 | 2903 | -3986 |
| SURF4 | 3001 | 1222 |
| SVIP | 642 | -4596 |
| SYK | 4192 | -5054 |
| TAB2 | 2942 | 1892 |
| TALDO1 | 4392 | -5245 |
| TANK | 3251 | -1331 |
| TAP1 | -3978 | -4218 |
| TAP2 | -4576 | 1506 |
| TAPBP | 975 | -1360 |
| TAX1BP1 | 2418 | -4470 |
| TBC1D10C | -4609 | 2261 |
| TBK1 | 1067 | -4616 |
| TCIRG1 | 3087 | -5082 |
| TCP1 | 1254 | 2168 |
| TEC | 3276 | -5839 |
| TGFB1 | 1959 | -6 |
| THEM4 | -4130 | -6129 |
| THOP1 | -3278 | -3580 |
| TICAM1 | 2569 | -2136 |
| TIFA | 1905 | -1726 |
| TIRAP | 2210 | -5182 |
| TLR1 | 4106 | -6127 |
| TLR2 | 4206 | -6586 |
| TLR3 | -4406 | -5820 |
| TLR5 | 4260 | 1823 |
| TLR6 | 4058 | -802 |
| TLR9 | -1850 | 2292 |
| TMBIM1 | 3776 | -1433 |
| TMC6 | -3874 | 2299 |
| TMEM179B | 140 | 276 |
| TMEM30A | 3589 | -1977 |
| TMEM63A | -3139 | -5444 |
| TNF | -2348 | -3779 |
| TNFAIP3 | -4067 | -785 |
| TNFRSF12A | 2924 | -994 |
| TNFRSF1A | 4299 | -4958 |
| TNFRSF1B | 2421 | 2416 |
| TNFRSF25 | -3862 | 2275 |
| TNFSF13 | 3783 | -5904 |
| TNFSF13B | 3109 | -6033 |
| TNFSF14 | 783 | 2460 |
| TNFSF9 | -1885 | 1627 |
| TNIP2 | 2166 | -5726 |
| TOLLIP | 3905 | -5037 |
| TOM1 | 4259 | -5118 |
| TP53 | -4034 | -739 |
| TPP2 | -3068 | -1752 |
| TPR | -2242 | -973 |
| TRAF2 | -4539 | -1442 |
| TRAF3 | -1701 | 2379 |
| TRAF6 | -80 | -6118 |
| TRAF7 | 3928 | -4769 |
| TRAIP | -4458 | -3435 |
| TRAPPC1 | 3441 | -3029 |
| TREML2 | 2657 | -6721 |
| TREX1 | -377 | -5868 |
| TRIB3 | -1802 | 1669 |
| TRIM11 | -1094 | 586 |
| TRIM14 | -2114 | -1735 |
| TRIM2 | -1371 | -4681 |
| TRIM21 | 775 | -6370 |
| TRIM22 | -4013 | -2766 |
| TRIM25 | 3700 | -3718 |
| TRIM26 | -3115 | -2905 |
| TRIM35 | -3395 | -31 |
| TRIM36 | -2087 | -5030 |
| TRIM37 | -2860 | -3006 |
| TRIM38 | 785 | -931 |
| TRIM39 | -3789 | -3317 |
| TRIM4 | 659 | 1988 |
| TRIM41 | 773 | -1538 |
| TRIM45 | -2497 | -5568 |
| TRIM46 | -2614 | -1262 |
| TRIM5 | -2217 | -3945 |
| TRIM56 | -2958 | 141 |
| TRIM62 | -3907 | -6401 |
| TRIM68 | -4679 | 1800 |
| TRIM8 | 3807 | 1000 |
| TRIM9 | 535 | -726 |
| TRIP12 | 2921 | -3017 |
| TRPC1 | -3412 | -2704 |
| TRPM2 | 4205 | -6600 |
| TSPAN14 | 2946 | 1366 |
| TUBB | -2209 | 1395 |
| TUBB4B | 3111 | 1856 |
| TXK | -4496 | 170 |
| TXLNA | -556 | -78 |
| TXN | 3732 | 284 |
| TXNDC5 | 122 | -5179 |
| TXNIP | -3347 | -2777 |
| TYK2 | 3021 | -3105 |
| TYROBP | 3270 | -6720 |
| UBA3 | 3420 | -2122 |
| UBA5 | -2767 | -4241 |
| UBA52 | 349 | 752 |
| UBA6 | 1163 | 1251 |
| UBA7 | -2452 | -6667 |
| UBAC1 | 3770 | -4908 |
| UBB | 2759 | -1321 |
| UBC | 1618 | -2568 |
| UBE2B | 2966 | -2486 |
| UBE2C | 1933 | 1091 |
| UBE2D1 | 4255 | -1581 |
| UBE2D2 | 1717 | -3799 |
| UBE2D3 | 3944 | -373 |
| UBE2D4 | -4207 | -3494 |
| UBE2E1 | 2822 | -5882 |
| UBE2E2 | 551 | -6256 |
| UBE2E3 | 1883 | -5759 |
| UBE2F | 3165 | -3774 |
| UBE2G1 | 1840 | -1626 |
| UBE2G2 | -2650 | -3560 |
| UBE2H | 3352 | -1867 |
| UBE2J1 | 4244 | -591 |
| UBE2J2 | 3722 | -368 |
| UBE2K | 2901 | 1379 |
| UBE2L3 | 3281 | -3496 |
| UBE2L6 | -4256 | -4206 |
| UBE2M | 3239 | -3585 |
| UBE2N | 607 | 1127 |
| UBE2O | 668 | -5963 |
| UBE2Q1 | 2284 | -1272 |
| UBE2Q2 | -4419 | -4146 |
| UBE2R2 | 3894 | -3277 |
| UBE2S | 1766 | 2449 |
| UBE2V1 | 2209 | -1021 |
| UBE2V2 | 934 | -3487 |
| UBE2W | 3522 | -618 |
| UBE2Z | -4046 | -4538 |
| UBE3A | 959 | 1814 |
| UBE3B | 594 | -244 |
| UBE3C | 2557 | 223 |
| UBE3D | -3973 | -5685 |
| UBOX5 | -347 | 1764 |
| UBR1 | -1432 | -415 |
| UBR2 | 1443 | -2614 |
| UFL1 | -2092 | 122 |
| UNC13D | 3311 | -6493 |
| UNC93B1 | 1479 | -4358 |
| UNKL | -696 | -4290 |
| USP18 | -4814 | -2616 |
| VAMP2 | -4559 | -2770 |
| VAMP3 | 3698 | 1210 |
| VAMP8 | 1989 | -6050 |
| VAPA | 4169 | -5592 |
| VASP | 3582 | -2892 |
| VAT1 | 4302 | -3481 |
| VAV1 | 3499 | -3184 |
| VAV2 | -1214 | -643 |
| VAV3 | 1824 | -6342 |
| VCL | 3157 | -5870 |
| VCP | 2902 | -2411 |
| VEGFA | 3235 | -2723 |
| VHL | 1262 | 1389 |
| VIM | 4364 | -2247 |
| VRK3 | 396 | -1398 |
| VTN | -613 | 2265 |
| WASF1 | 4414 | -1056 |
| WASF2 | 3782 | -2654 |
| WASL | 87 | -4742 |
| WIPF1 | 177 | -4382 |
| WIPF2 | 2249 | -2523 |
| WSB1 | 3475 | -637 |
| WWP1 | -3604 | -1865 |
| XAF1 | -4727 | -2525 |
| XRCC5 | 2075 | -3770 |
| XRCC6 | -1335 | 376 |
| YES1 | -4772 | -4415 |
| YPEL5 | 2788 | -1479 |
| YWHAB | 2611 | 2125 |
| YWHAZ | 2200 | 541 |
| ZAP70 | -4650 | 2499 |
| ZBP1 | -4869 | -410 |
| ZBTB16 | 215 | 2289 |
| ZEB1 | -2414 | -1406 |
| ZNRF1 | 3362 | -5381 |
| ZNRF2 | 198 | 1850 |
Signaling by Receptor Tyrosine Kinases
| metric | value |
|---|---|
| setSize | 284 |
| pMANOVA | 6.36e-13 |
| p.adjustMANOVA | 3.18e-12 |
| s.dist | 0.256 |
| s.RNA | 0.253 |
| s.meth | 0.0417 |
| p.RNA | 3.55e-13 |
| p.meth | 0.23 |
| Gene | RNA | meth |
|---|---|---|
| CLTC | 4149 | 2477 |
| FURIN | 4191 | 2351 |
| PTPRJ | 3428 | 2365 |
| ADAP1 | 3278 | 2385 |
| ATP6V1A | 4318 | 1580 |
| ATP6V0B | 3921 | 1604 |
| PPP2CB | 3381 | 1797 |
| MAPK1 | 3249 | 1865 |
| BRK1 | 2983 | 1970 |
| MKNK1 | 3672 | 1538 |
| TAB2 | 2942 | 1892 |
| YWHAB | 2611 | 2125 |
| SHB | 2414 | 2212 |
| APH1B | 2555 | 2056 |
| RHOA | 3753 | 1313 |
| CBL | 3241 | 1456 |
| PTPN1 | 2254 | 2074 |
| FOS | 2120 | 2149 |
| ADAM10 | 4030 | 976 |
| RAC1 | 4031 | 971 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAMP | -1084 | -5298 |
| ABI1 | 3018 | -1788 |
| ABI2 | -4048 | -5451 |
| ADAM10 | 4030 | 976 |
| ADAM17 | 3634 | 774 |
| ADAP1 | 3278 | 2385 |
| ADORA2A | 1094 | -5935 |
| AHCYL1 | 2658 | -3553 |
| AKT1 | 1234 | -1942 |
| AKT2 | 133 | -141 |
| AP2A1 | 2869 | -4887 |
| AP2M1 | 3936 | 20 |
| AP2S1 | 3581 | -3262 |
| APH1A | 1453 | -6066 |
| APH1B | 2555 | 2056 |
| ARF6 | 422 | -3567 |
| ARHGEF7 | -1379 | -5507 |
| ATF1 | 2245 | -2565 |
| ATP6V0A1 | 4375 | -5877 |
| ATP6V0A2 | -4811 | 689 |
| ATP6V0B | 3921 | 1604 |
| ATP6V0C | 4218 | -4697 |
| ATP6V0D1 | 4282 | -1003 |
| ATP6V0E1 | 3919 | -2865 |
| ATP6V0E2 | -4420 | -6625 |
| ATP6V1A | 4318 | 1580 |
| ATP6V1B2 | 4178 | -4232 |
| ATP6V1C1 | 3887 | 655 |
| ATP6V1D | 4174 | -1234 |
| ATP6V1E1 | 3588 | -3948 |
| ATP6V1F | 2338 | 1350 |
| ATP6V1G2 | -3312 | -3714 |
| ATP6V1H | 3607 | -1695 |
| BAIAP2 | -72 | 1977 |
| BAX | 2357 | -3623 |
| BRAF | 403 | -4347 |
| BRK1 | 2983 | 1970 |
| CALM1 | -626 | -5019 |
| CAV1 | 619 | -2432 |
| CBL | 3241 | 1456 |
| CDC42 | 3268 | -2719 |
| CDK5 | 3929 | -506 |
| CDK5R1 | -346 | -2113 |
| CHD4 | -1351 | -4634 |
| CHEK1 | -741 | -211 |
| CLTA | 3788 | -5077 |
| CLTC | 4149 | 2477 |
| COL9A2 | -3430 | -2895 |
| CREB1 | -430 | -672 |
| CRK | 4091 | -4581 |
| CRKL | 1387 | -906 |
| CSK | 1990 | 862 |
| CTNNB1 | 2626 | -1691 |
| CTNND1 | -2821 | 1566 |
| CUL5 | 265 | -3077 |
| CYBA | 2922 | 1006 |
| CYFIP1 | 4295 | -6630 |
| CYFIP2 | -3754 | 2232 |
| DIAPH1 | -283 | 1033 |
| DLG4 | 4153 | -3021 |
| DNAL4 | 1142 | -45 |
| DNM1 | 1225 | -5619 |
| DNM2 | 2448 | 738 |
| DOCK7 | -708 | -5883 |
| DUSP3 | 4305 | -1798 |
| DUSP4 | -1957 | -3176 |
| DUSP6 | 1570 | -6763 |
| DUSP7 | -960 | -1322 |
| EGR1 | 1023 | -163 |
| EGR2 | -450 | -2628 |
| ELMO1 | 2547 | -2714 |
| ELMO2 | 1591 | 1326 |
| EP300 | 2471 | -4509 |
| EPN1 | 3595 | -2171 |
| EPS15 | 1457 | -654 |
| EPS15L1 | 1251 | -3901 |
| ERBB2 | -4865 | -5145 |
| ESRP2 | -2936 | -6611 |
| FER | 541 | -3332 |
| FES | 4278 | -6334 |
| FGF9 | -2970 | 1634 |
| FGFBP3 | -3207 | 1 |
| FGFRL1 | -4558 | -2409 |
| FLT3LG | -3495 | 1573 |
| FOS | 2120 | 2149 |
| FOSB | 418 | -332 |
| FOSL1 | 4028 | 737 |
| FRS2 | -1025 | -1999 |
| FRS3 | 3166 | -2329 |
| FURIN | 4191 | 2351 |
| FYN | -4495 | 1957 |
| GAB2 | 3629 | -6153 |
| GALNT3 | 557 | -2941 |
| GGA3 | 1326 | 450 |
| GRAP2 | 1736 | -5763 |
| GRB10 | 4386 | -70 |
| GRB2 | 4320 | -2295 |
| GTF2F1 | 1854 | -1723 |
| GTF2F2 | 2104 | -2885 |
| HBEGF | 1889 | -6428 |
| HGS | 1647 | 2123 |
| HNRNPF | 1366 | -58 |
| HNRNPH1 | -2604 | -1020 |
| HNRNPM | 1976 | -4945 |
| HRAS | -1008 | -4780 |
| HSP90AA1 | 411 | -781 |
| HSPB1 | 582 | -4137 |
| ID1 | 1843 | -3980 |
| ID2 | -4082 | 566 |
| ID3 | -3355 | 1995 |
| IGF1R | 2394 | -4939 |
| INSR | 3730 | -2668 |
| IRS1 | 533 | -4060 |
| IRS2 | 3903 | -5410 |
| ITCH | 407 | -1366 |
| ITGA2 | 1478 | -3856 |
| ITGAV | 2457 | -5201 |
| ITPR1 | -2478 | -3278 |
| ITPR2 | 2315 | -6107 |
| ITPR3 | -3717 | -3427 |
| JAK2 | 857 | -1751 |
| JUNB | 2850 | -3031 |
| JUND | 478 | -1239 |
| KIDINS220 | 3009 | 189 |
| KRAS | 1276 | 440 |
| LAMA2 | -3504 | -1315 |
| LAMB2 | 156 | -2207 |
| LCK | -4596 | 2489 |
| LRIG1 | -3766 | -3314 |
| LYL1 | 3697 | -6435 |
| MAP2K1 | 4183 | -698 |
| MAP2K2 | 2840 | -3962 |
| MAP2K5 | 1370 | -3572 |
| MAPK1 | 3249 | 1865 |
| MAPK14 | 4207 | -3529 |
| MAPK3 | 4121 | -2448 |
| MAPK7 | -412 | -1630 |
| MAPKAP1 | 1911 | 1057 |
| MAPKAPK2 | 1428 | 2012 |
| MAPKAPK3 | 3794 | -4540 |
| MEF2A | 3571 | -2822 |
| MEF2D | -929 | -3018 |
| MEMO1 | 4063 | -3910 |
| MKNK1 | 3672 | 1538 |
| MLST8 | 117 | 287 |
| MST1 | 270 | 1514 |
| MST1R | -1712 | -4446 |
| MTOR | -3429 | -1813 |
| MXD4 | -4252 | -2602 |
| NAB1 | 416 | -2731 |
| NAB2 | -3772 | 989 |
| NCBP1 | -1807 | -3745 |
| NCBP2 | -3329 | -4067 |
| NCF4 | 4298 | -6732 |
| NCK1 | -4361 | -1408 |
| NCK2 | 1848 | -4310 |
| NCKAP1L | 3360 | -6178 |
| NCOR1 | 2341 | -3738 |
| NCSTN | 4254 | -3821 |
| NEDD4 | 2511 | -5611 |
| NELFB | 115 | 1822 |
| NOS3 | -620 | -1770 |
| NTRK1 | -2715 | 898 |
| PAG1 | 2019 | 262 |
| PAK1 | 3703 | -3995 |
| PAK2 | 3682 | -3961 |
| PCSK5 | 1812 | -4883 |
| PDE3B | -4275 | -4025 |
| PDPK1 | 2474 | 167 |
| PGF | -1789 | 1959 |
| PIK3CA | 1703 | -1445 |
| PIK3R1 | -3307 | 2310 |
| PIK3R2 | 1887 | -1223 |
| PIK3R3 | -4692 | -22 |
| PIK3R4 | -1215 | -3425 |
| PLCG1 | -4158 | -3541 |
| POLR2A | -928 | -3832 |
| POLR2B | -751 | 926 |
| POLR2C | 501 | 1027 |
| POLR2D | -1201 | -2419 |
| POLR2E | 3283 | -1584 |
| POLR2F | 1692 | -4483 |
| POLR2G | 1190 | -2402 |
| POLR2H | -882 | 1944 |
| POLR2I | 123 | -5210 |
| POLR2K | -537 | -2424 |
| PPP2CA | 3707 | 300 |
| PPP2CB | 3381 | 1797 |
| PPP2R1B | -84 | -2554 |
| PPP2R5D | 771 | -4349 |
| PRKACA | 4378 | -6032 |
| PRKACB | -4656 | 455 |
| PRKCA | 356 | 810 |
| PRKCB | 3029 | -4518 |
| PRKCD | 4154 | 584 |
| PRKCE | -2638 | -5632 |
| PRKCZ | -4470 | -5220 |
| PRR5 | -4676 | -1591 |
| PSEN1 | 3540 | -3407 |
| PSEN2 | -2508 | -5155 |
| PSENEN | 2260 | -3620 |
| PTBP1 | -68 | -1843 |
| PTK2 | 1629 | 920 |
| PTK2B | 3527 | 40 |
| PTPN1 | 2254 | 2074 |
| PTPN11 | 2038 | -2302 |
| PTPN12 | 3660 | -1077 |
| PTPN18 | 2482 | 693 |
| PTPN2 | 3316 | -3701 |
| PTPN6 | 2452 | -4586 |
| PTPRJ | 3428 | 2365 |
| PTPRU | -816 | 1974 |
| PXN | 2531 | -5712 |
| RAB4A | 3532 | -5479 |
| RAB4B | 1028 | 1318 |
| RAC1 | 4031 | 971 |
| RALA | 864 | -262 |
| RALB | 3814 | -1081 |
| RALGDS | -4770 | 1254 |
| RANBP10 | 816 | -5295 |
| RANBP9 | 2299 | -1361 |
| RAP1A | 3148 | 323 |
| RAP1B | 1058 | -1031 |
| RAPGEF1 | -3458 | 1868 |
| RASA1 | 664 | -167 |
| REST | 276 | 2128 |
| RHOA | 3753 | 1313 |
| RICTOR | -3383 | 1651 |
| RIT1 | 4213 | 337 |
| RNF41 | 3797 | 109 |
| ROCK1 | 3246 | -985 |
| RPS27A | -2201 | -2138 |
| RPS6KA1 | 3372 | -6629 |
| RPS6KA2 | 1006 | -1784 |
| RPS6KA5 | -4445 | -514 |
| SGK1 | 1689 | -6076 |
| SH2B3 | 1358 | 1699 |
| SH2D2A | -4888 | 2200 |
| SH3GL1 | 3324 | 1075 |
| SHB | 2414 | 2212 |
| SHC1 | 1472 | -2954 |
| SOCS1 | 1375 | -2999 |
| SOS1 | -1748 | -6775 |
| SPRED1 | -2916 | -6227 |
| SPRED2 | 2927 | 521 |
| SPRY1 | 727 | -5532 |
| SPRY2 | -1386 | -5919 |
| SRC | -2999 | -4427 |
| SRF | 3015 | -1284 |
| STAM | 397 | 770 |
| STAM2 | 2488 | -2181 |
| STAT1 | -4529 | 2195 |
| STAT3 | 3628 | -3606 |
| STAT5A | 2943 | -6427 |
| STAT5B | 2923 | -3446 |
| STAT6 | 2340 | -3911 |
| STMN1 | -2924 | -3648 |
| STUB1 | -330 | -2168 |
| TAB2 | 2942 | 1892 |
| TCF12 | -386 | -4702 |
| TCIRG1 | 3087 | -5082 |
| TEC | 3276 | -5839 |
| TGFA | 4083 | -3020 |
| THBS3 | 2988 | -2835 |
| THEM4 | -4130 | -6129 |
| TIA1 | -1628 | -1498 |
| TIAL1 | -681 | -277 |
| TLR9 | -1850 | 2292 |
| TRIB3 | -1802 | 1669 |
| UBA52 | 349 | 752 |
| UBB | 2759 | -1321 |
| UBC | 1618 | -2568 |
| USP8 | 2632 | -424 |
| VAV1 | 3499 | -3184 |
| VAV2 | -1214 | -643 |
| VAV3 | 1824 | -6342 |
| VEGFA | 3235 | -2723 |
| VRK3 | 396 | -1398 |
| WASF1 | 4414 | -1056 |
| WASF2 | 3782 | -2654 |
| WWOX | -4138 | 1732 |
| WWP1 | -3604 | -1865 |
| YES1 | -4772 | -4415 |
| YWHAB | 2611 | 2125 |
Signaling by Interleukins
| metric | value |
|---|---|
| setSize | 263 |
| pMANOVA | 1.38e-11 |
| p.adjustMANOVA | 5.13e-11 |
| s.dist | 0.253 |
| s.RNA | 0.253 |
| s.meth | 0.0151 |
| p.RNA | 2.56e-12 |
| p.meth | 0.677 |
| Gene | RNA | meth |
|---|---|---|
| SOCS3 | 4399 | 2178 |
| LCP1 | 3793 | 2024 |
| IL19 | 2820 | 2517 |
| PPP2CB | 3381 | 1797 |
| MAPK1 | 3249 | 1865 |
| NOD2 | 3833 | 1528 |
| TNFRSF1B | 2421 | 2416 |
| TAB2 | 2942 | 1892 |
| ITGB2 | 4114 | 1322 |
| BATF | 2612 | 2070 |
| PSMA7 | 3028 | 1752 |
| PIK3CD | 2422 | 2189 |
| BCL2L1 | 3979 | 1306 |
| PSMD1 | 3112 | 1660 |
| CNN2 | 2764 | 1735 |
| CHUK | 3543 | 1343 |
| CBL | 3241 | 1456 |
| FOS | 2120 | 2149 |
| PSME3 | 3715 | 1116 |
| SMARCA4 | 1758 | 2317 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AIP | -1061 | 1761 |
| AKT1 | 1234 | -1942 |
| ALOX5 | 4150 | -6082 |
| APP | 4249 | -5300 |
| ARF1 | 4184 | -6686 |
| ATF1 | 2245 | -2565 |
| BATF | 2612 | 2070 |
| BCL2 | -1421 | 2361 |
| BCL2L1 | 3979 | 1306 |
| BCL6 | 4248 | -299 |
| BIRC5 | 1291 | -84 |
| BRWD1 | -3183 | -3884 |
| BTRC | -1493 | -2427 |
| CANX | 2151 | -4839 |
| CAPZA1 | 3648 | 572 |
| CASP1 | 1501 | -1448 |
| CASP3 | -208 | -2764 |
| CBL | 3241 | 1456 |
| CCND1 | -2214 | -6213 |
| CCR1 | 4074 | -6480 |
| CD4 | -1648 | -6372 |
| CDC42 | 3268 | -2719 |
| CDKN1A | 1646 | -3540 |
| CEBPD | 4044 | -5142 |
| CFL1 | 3683 | 912 |
| CHUK | 3543 | 1343 |
| CISH | 1836 | 1748 |
| CNN2 | 2764 | 1735 |
| CREB1 | -430 | -672 |
| CRK | 4091 | -4581 |
| CRKL | 1387 | -906 |
| CSF1 | -622 | -5924 |
| CTF1 | 1521 | -5738 |
| CUL1 | -4281 | -5146 |
| CXCL2 | 2093 | -6755 |
| DUSP3 | 4305 | -1798 |
| DUSP4 | -1957 | -3176 |
| DUSP6 | 1570 | -6763 |
| DUSP7 | -960 | -1322 |
| FBXW11 | 2510 | -6747 |
| FOS | 2120 | 2149 |
| FOXO1 | -3290 | -5036 |
| FOXO3 | 3966 | 711 |
| FYN | -4495 | 1957 |
| GAB2 | 3629 | -6153 |
| GATA3 | -4799 | 1861 |
| GRB2 | 4320 | -2295 |
| GSDMD | 614 | -3378 |
| GSTO1 | 4196 | -170 |
| HIF1A | 3219 | -3349 |
| HMGB1 | -86 | -1263 |
| HNRNPA2B1 | 1133 | -2665 |
| HNRNPF | 1366 | -58 |
| HSP90AA1 | 411 | -781 |
| HSP90B1 | 647 | -1371 |
| HSPA9 | -3436 | -200 |
| ICAM1 | 2796 | -5333 |
| IKBKB | -1640 | -3894 |
| IL10RA | -3866 | 1263 |
| IL10RB | 4239 | -6138 |
| IL12A | -2552 | -5748 |
| IL12RB1 | -4755 | -1444 |
| IL12RB2 | -4683 | -5603 |
| IL15 | -1531 | -5098 |
| IL15RA | 826 | -3679 |
| IL16 | -3409 | 656 |
| IL17C | -2074 | -1115 |
| IL17RA | 4257 | -3604 |
| IL17RC | 55 | -1157 |
| IL18BP | -3851 | -5936 |
| IL18R1 | 1399 | 475 |
| IL19 | 2820 | 2517 |
| IL1RAP | 3063 | -456 |
| IL21R | -4834 | 401 |
| IL23A | -3838 | -6478 |
| IL27RA | 1165 | -1230 |
| IL2RA | -2295 | -6462 |
| IL2RB | -4882 | 2472 |
| IL32 | -3617 | 2512 |
| IL4R | 3174 | -4452 |
| IL6R | 3645 | -6410 |
| IL6ST | 1415 | 1094 |
| INPP5D | -1207 | -3735 |
| INPPL1 | 4166 | -2224 |
| IRAK2 | -3327 | -1457 |
| IRAK3 | 4208 | -6295 |
| IRF4 | -3062 | 1782 |
| IRS1 | 533 | -4060 |
| IRS2 | 3903 | -5410 |
| ITGB2 | 4114 | 1322 |
| JAK1 | -4072 | -1022 |
| JAK2 | 857 | -1751 |
| JUN | 1286 | 69 |
| JUNB | 2850 | -3031 |
| LCK | -4596 | 2489 |
| LCP1 | 3793 | 2024 |
| LGALS9 | 979 | -6589 |
| LMNB1 | 4342 | -942 |
| MAP2K1 | 4183 | -698 |
| MAP2K3 | 4006 | -2657 |
| MAP2K4 | 2891 | -5363 |
| MAP2K6 | 4082 | -1130 |
| MAP2K7 | 514 | -3915 |
| MAP3K3 | 3850 | 64 |
| MAP3K7 | 761 | -2089 |
| MAP3K8 | 2489 | 1442 |
| MAPK1 | 3249 | 1865 |
| MAPK14 | 4207 | -3529 |
| MAPK3 | 4121 | -2448 |
| MAPK7 | -412 | -1630 |
| MAPK8 | -3265 | 6 |
| MAPK9 | -2259 | 872 |
| MAPKAPK2 | 1428 | 2012 |
| MAPKAPK3 | 3794 | -4540 |
| MEF2A | 3571 | -2822 |
| MIF | -1146 | -2943 |
| MTAP | -1778 | -5878 |
| MUC1 | 2718 | -5557 |
| MYD88 | 3649 | -1927 |
| NFKB2 | -367 | 388 |
| NFKBIA | 2851 | 1159 |
| NFKBIB | -48 | -3368 |
| NKIRAS1 | 116 | -3490 |
| NKIRAS2 | 4346 | -5039 |
| NOD1 | -4837 | -5170 |
| NOD2 | 3833 | 1528 |
| OSM | 3426 | -3652 |
| P4HB | 3831 | -1549 |
| PAK2 | 3682 | -3961 |
| PDCD4 | -4586 | 1941 |
| PELI1 | 2800 | -3839 |
| PELI2 | 3750 | -2561 |
| PELI3 | 3383 | -4323 |
| PIK3CA | 1703 | -1445 |
| PIK3CD | 2422 | 2189 |
| PIK3R1 | -3307 | 2310 |
| PIK3R2 | 1887 | -1223 |
| PIK3R3 | -4692 | -22 |
| PIM1 | 3377 | -5227 |
| PITPNA | 2860 | -2752 |
| POU2F1 | 470 | 733 |
| PPIA | -2133 | 490 |
| PPP2CA | 3707 | 300 |
| PPP2CB | 3381 | 1797 |
| PPP2R1B | -84 | -2554 |
| PPP2R5D | 771 | -4349 |
| PRKACA | 4378 | -6032 |
| PRTN3 | 2825 | -6448 |
| PSMA1 | 3158 | -1782 |
| PSMA2 | 2052 | 1205 |
| PSMA3 | -1612 | -2824 |
| PSMA5 | -1869 | 592 |
| PSMA6 | 2386 | -1838 |
| PSMA7 | 3028 | 1752 |
| PSMB1 | 1131 | -1179 |
| PSMB10 | -1758 | -4718 |
| PSMB2 | 1439 | 2355 |
| PSMB3 | 3076 | -2678 |
| PSMB5 | 3630 | -4604 |
| PSMB6 | 2854 | -3576 |
| PSMB7 | 3856 | -2038 |
| PSMB8 | -921 | 1189 |
| PSMB9 | -4276 | -1453 |
| PSMC1 | 2977 | -5705 |
| PSMC3 | 624 | -4615 |
| PSMC4 | -3133 | 1003 |
| PSMC5 | -287 | -3263 |
| PSMC6 | 2757 | -5508 |
| PSMD1 | 3112 | 1660 |
| PSMD11 | 2532 | -2152 |
| PSMD12 | 2710 | 1314 |
| PSMD13 | 2376 | 1328 |
| PSMD14 | 836 | -2484 |
| PSMD2 | 3204 | -85 |
| PSMD3 | 1696 | -4331 |
| PSMD4 | 3806 | -4683 |
| PSMD6 | 3465 | -5488 |
| PSMD7 | 2383 | 7 |
| PSMD8 | 2270 | -3290 |
| PSMD9 | 3321 | -2041 |
| PSME1 | -3548 | -2343 |
| PSME2 | -3731 | -2364 |
| PSME3 | 3715 | 1116 |
| PSME4 | -1884 | -3380 |
| PSMF1 | 2775 | -4867 |
| PTK2B | 3527 | 40 |
| PTPN11 | 2038 | -2302 |
| PTPN12 | 3660 | -1077 |
| PTPN13 | -3534 | -6489 |
| PTPN18 | 2482 | 693 |
| PTPN2 | 3316 | -3701 |
| PTPN23 | -372 | -3227 |
| PTPN4 | -4818 | -3156 |
| PTPN6 | 2452 | -4586 |
| PTPN7 | -4023 | -1888 |
| PTPN9 | 2799 | -1265 |
| RALA | 864 | -262 |
| RAP1B | 1058 | -1031 |
| RAPGEF1 | -3458 | 1868 |
| RBX1 | 1368 | -3241 |
| RELA | -542 | 2085 |
| RORA | -4672 | 2287 |
| RPLP0 | -320 | -185 |
| RPS27A | -2201 | -2138 |
| RPS6KA1 | 3372 | -6629 |
| RPS6KA2 | 1006 | -1784 |
| RPS6KA5 | -4445 | -514 |
| S1PR1 | -3180 | 2436 |
| SHC1 | 1472 | -2954 |
| SIGIRR | -3958 | 290 |
| SKP1 | 1536 | -2290 |
| SMAD3 | -4538 | -4628 |
| SMARCA4 | 1758 | 2317 |
| SNRPA1 | -3561 | -3336 |
| SOCS1 | 1375 | -2999 |
| SOCS2 | -757 | 378 |
| SOCS3 | 4399 | 2178 |
| SOCS5 | 1047 | -4583 |
| SOD1 | -1475 | -1019 |
| SOD2 | 1587 | 573 |
| SOS1 | -1748 | -6775 |
| SOS2 | 3740 | -4105 |
| SQSTM1 | 1438 | -952 |
| STAT1 | -4529 | 2195 |
| STAT2 | -3894 | -3295 |
| STAT3 | 3628 | -3606 |
| STAT4 | -4875 | -425 |
| STAT5A | 2943 | -6427 |
| STAT5B | 2923 | -3446 |
| STAT6 | 2340 | -3911 |
| STX1A | -1213 | -2461 |
| STX3 | 3861 | -1755 |
| STX4 | 189 | -6001 |
| STXBP2 | 4170 | -6352 |
| SYK | 4192 | -5054 |
| TAB2 | 2942 | 1892 |
| TALDO1 | 4392 | -5245 |
| TBK1 | 1067 | -4616 |
| TCP1 | 1254 | 2168 |
| TEC | 3276 | -5839 |
| TGFB1 | 1959 | -6 |
| TNF | -2348 | -3779 |
| TNFRSF1A | 4299 | -4958 |
| TNFRSF1B | 2421 | 2416 |
| TNIP2 | 2166 | -5726 |
| TOLLIP | 3905 | -5037 |
| TP53 | -4034 | -739 |
| TRAF6 | -80 | -6118 |
| TXLNA | -556 | -78 |
| TYK2 | 3021 | -3105 |
| UBA52 | 349 | 752 |
| UBB | 2759 | -1321 |
| UBC | 1618 | -2568 |
| UBE2N | 607 | 1127 |
| UBE2V1 | 2209 | -1021 |
| VAMP2 | -4559 | -2770 |
| VAV1 | 3499 | -3184 |
| VEGFA | 3235 | -2723 |
| VIM | 4364 | -2247 |
| VRK3 | 396 | -1398 |
| YES1 | -4772 | -4415 |
| YWHAZ | 2200 | 541 |
| ZEB1 | -2414 | -1406 |
rRNA processing
| metric | value |
|---|---|
| setSize | 159 |
| pMANOVA | 1.71e-11 |
| p.adjustMANOVA | 5.13e-11 |
| s.dist | 0.336 |
| s.RNA | -0.289 |
| s.meth | 0.171 |
| p.RNA | 3.63e-10 |
| p.meth | 0.000207 |
| Gene | RNA | meth |
|---|---|---|
| NOP14 | -4022 | 2384 |
| RRP9 | -3589 | 2034 |
| RPL3 | -2885 | 2313 |
| MTERF4 | -4033 | 1559 |
| RPL23A | -3334 | 1843 |
| EXOSC2 | -4132 | 1269 |
| NOL9 | -3670 | 1426 |
| RPS11 | -2332 | 2115 |
| RPL13A | -2727 | 1802 |
| EXOSC8 | -4363 | 1020 |
| SNU13 | -2174 | 1961 |
| RPL32 | -2103 | 1928 |
| RPP38 | -2263 | 1598 |
| WDR75 | -3509 | 1028 |
| NOC4L | -1668 | 1990 |
| RPS2 | -1344 | 2392 |
| RPL35 | -2671 | 952 |
| RPL4 | -1064 | 2321 |
| RPS10 | -1780 | 1246 |
| EXOSC5 | -1377 | 1591 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| BMS1 | -4492 | -2552 |
| BYSL | -1331 | -88 |
| C1D | 1194 | 510 |
| CSNK1D | 760 | -1777 |
| CSNK1E | -3709 | -4750 |
| DCAF13 | -1698 | -2001 |
| DDX21 | 1018 | 760 |
| DDX47 | -4257 | -3056 |
| DDX49 | 1815 | -4408 |
| DDX52 | 142 | -1954 |
| DHX37 | -2753 | -312 |
| DIS3 | -1292 | -762 |
| EBNA1BP2 | -1224 | 1600 |
| ELAC2 | -4545 | -916 |
| ERI1 | 2157 | 130 |
| EXOSC1 | -319 | -290 |
| EXOSC10 | -4315 | -1580 |
| EXOSC2 | -4132 | 1269 |
| EXOSC3 | 161 | -2555 |
| EXOSC4 | 3305 | -4410 |
| EXOSC5 | -1377 | 1591 |
| EXOSC6 | -3464 | 545 |
| EXOSC7 | -3889 | -4665 |
| EXOSC8 | -4363 | 1020 |
| FAU | -124 | -3862 |
| FBL | -3651 | -2611 |
| FCF1 | 1633 | -2675 |
| FTSJ3 | -1200 | -670 |
| GAR1 | -2203 | -4416 |
| GNL3 | -2859 | -1419 |
| HEATR1 | -3738 | -1985 |
| IMP3 | -3288 | 99 |
| IMP4 | -4084 | -2925 |
| ISG20L2 | 1309 | 1893 |
| KRR1 | -2907 | -6562 |
| LTV1 | -1284 | -3205 |
| MPHOSPH10 | -2537 | -57 |
| MPHOSPH6 | 685 | -5463 |
| MRM1 | -3829 | -5990 |
| MTERF4 | -4033 | 1559 |
| NCL | -3204 | -2515 |
| NHP2 | -1038 | -260 |
| NIP7 | -1813 | -1760 |
| NOB1 | -3724 | -1000 |
| NOC4L | -1668 | 1990 |
| NOL11 | -3807 | -2629 |
| NOL12 | 1851 | 505 |
| NOL6 | -4043 | 526 |
| NOL9 | -3670 | 1426 |
| NOP10 | 3759 | -3526 |
| NOP14 | -4022 | 2384 |
| NOP2 | -3530 | -2438 |
| NOP56 | -4540 | -523 |
| NOP58 | -3529 | -2406 |
| NSUN4 | -1451 | -3469 |
| PDCD11 | -4401 | -2174 |
| PELP1 | -4054 | -1579 |
| PES1 | -609 | -3908 |
| PNO1 | -2170 | -5495 |
| PWP2 | -378 | 681 |
| RBM28 | -4493 | -685 |
| RCL1 | -244 | -1421 |
| RIOK1 | -1131 | -2098 |
| RIOK2 | 300 | -954 |
| RIOK3 | 4013 | -2443 |
| RPL10A | -2096 | -648 |
| RPL11 | -1944 | -2771 |
| RPL13 | -1024 | -191 |
| RPL13A | -2727 | 1802 |
| RPL14 | -2104 | -100 |
| RPL15 | -313 | -4694 |
| RPL17 | -1654 | 1099 |
| RPL18 | -1546 | -2031 |
| RPL18A | -1876 | -4966 |
| RPL22 | -1434 | -3996 |
| RPL23 | -990 | -566 |
| RPL23A | -3334 | 1843 |
| RPL26 | -2060 | -1489 |
| RPL26L1 | 3079 | -2860 |
| RPL27A | -1942 | -55 |
| RPL28 | -456 | -3478 |
| RPL29 | -1075 | 305 |
| RPL3 | -2885 | 2313 |
| RPL31 | -1362 | -2278 |
| RPL32 | -2103 | 1928 |
| RPL34 | -2147 | -3159 |
| RPL35 | -2671 | 952 |
| RPL36 | -1614 | 4 |
| RPL36AL | 9 | 1901 |
| RPL37 | -1982 | -126 |
| RPL37A | -1178 | 211 |
| RPL38 | -1800 | -818 |
| RPL39L | -2993 | -329 |
| RPL4 | -1064 | 2321 |
| RPL41 | -2172 | -229 |
| RPL6 | -999 | 474 |
| RPL7 | -589 | -6019 |
| RPL8 | -373 | -5267 |
| RPL9 | -566 | 741 |
| RPLP0 | -320 | -185 |
| RPLP1 | 3 | -4053 |
| RPLP2 | -2265 | 579 |
| RPP14 | 974 | -354 |
| RPP21 | -1631 | -5256 |
| RPP25 | -2741 | -5917 |
| RPP30 | -2675 | -5522 |
| RPP38 | -2263 | 1598 |
| RPP40 | -1467 | -1426 |
| RPS10 | -1780 | 1246 |
| RPS11 | -2332 | 2115 |
| RPS12 | -1841 | -379 |
| RPS15 | -1095 | 1808 |
| RPS15A | -1762 | 1086 |
| RPS16 | -1410 | 1043 |
| RPS18 | -2520 | -3281 |
| RPS19 | -2212 | -4563 |
| RPS2 | -1344 | 2392 |
| RPS20 | -3028 | -1962 |
| RPS23 | -1958 | -1981 |
| RPS24 | -87 | -2012 |
| RPS25 | -1980 | 254 |
| RPS26 | -446 | -3094 |
| RPS27A | -2201 | -2138 |
| RPS27L | 649 | -2218 |
| RPS28 | -1426 | 525 |
| RPS29 | -2606 | -159 |
| RPS3 | -1822 | -632 |
| RPS3A | -1419 | 1275 |
| RPS5 | -1744 | -1026 |
| RPS6 | -1906 | -1785 |
| RPS7 | -1509 | -2594 |
| RPS8 | -627 | 1886 |
| RPS9 | 2097 | 139 |
| RPSA | -1968 | -1486 |
| RRP1 | -924 | 77 |
| RRP7A | -846 | -2961 |
| RRP9 | -3589 | 2034 |
| SENP3 | 966 | -1248 |
| SNU13 | -2174 | 1961 |
| TBL3 | -1027 | 994 |
| TEX10 | -3427 | -1947 |
| TFB1M | -4290 | -3739 |
| THUMPD1 | -3443 | -4292 |
| TRMT112 | 233 | -4666 |
| TSR1 | -3410 | -3041 |
| TSR3 | 1337 | 1167 |
| UBA52 | 349 | 752 |
| UTP15 | -3872 | -2796 |
| UTP18 | 1940 | -3819 |
| UTP20 | -3834 | -1372 |
| UTP3 | -874 | -3665 |
| UTP6 | -1347 | -1904 |
| WDR12 | 1988 | 706 |
| WDR18 | -691 | -2042 |
| WDR3 | -2064 | -5710 |
| WDR36 | -1177 | -2277 |
| WDR43 | -2494 | -4225 |
| WDR75 | -3509 | 1028 |
| XRN2 | 4366 | -5589 |
Major pathway of rRNA processing in the nucleolus and cytosol
| metric | value |
|---|---|
| setSize | 147 |
| pMANOVA | 5.25e-11 |
| p.adjustMANOVA | 1.31e-10 |
| s.dist | 0.342 |
| s.RNA | -0.283 |
| s.meth | 0.193 |
| p.RNA | 3.83e-09 |
| p.meth | 5.68e-05 |
| Gene | RNA | meth |
|---|---|---|
| NOP14 | -4022 | 2384 |
| RRP9 | -3589 | 2034 |
| RPL3 | -2885 | 2313 |
| RPL23A | -3334 | 1843 |
| EXOSC2 | -4132 | 1269 |
| NOL9 | -3670 | 1426 |
| RPS11 | -2332 | 2115 |
| RPL13A | -2727 | 1802 |
| EXOSC8 | -4363 | 1020 |
| SNU13 | -2174 | 1961 |
| RPL32 | -2103 | 1928 |
| RPP38 | -2263 | 1598 |
| WDR75 | -3509 | 1028 |
| NOC4L | -1668 | 1990 |
| RPS2 | -1344 | 2392 |
| RPL35 | -2671 | 952 |
| RPL4 | -1064 | 2321 |
| RPS10 | -1780 | 1246 |
| EXOSC5 | -1377 | 1591 |
| NOL6 | -4043 | 526 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| BMS1 | -4492 | -2552 |
| BYSL | -1331 | -88 |
| C1D | 1194 | 510 |
| CSNK1D | 760 | -1777 |
| CSNK1E | -3709 | -4750 |
| DCAF13 | -1698 | -2001 |
| DDX21 | 1018 | 760 |
| DDX47 | -4257 | -3056 |
| DDX49 | 1815 | -4408 |
| DDX52 | 142 | -1954 |
| DHX37 | -2753 | -312 |
| DIS3 | -1292 | -762 |
| EBNA1BP2 | -1224 | 1600 |
| ERI1 | 2157 | 130 |
| EXOSC1 | -319 | -290 |
| EXOSC10 | -4315 | -1580 |
| EXOSC2 | -4132 | 1269 |
| EXOSC3 | 161 | -2555 |
| EXOSC4 | 3305 | -4410 |
| EXOSC5 | -1377 | 1591 |
| EXOSC6 | -3464 | 545 |
| EXOSC7 | -3889 | -4665 |
| EXOSC8 | -4363 | 1020 |
| FAU | -124 | -3862 |
| FBL | -3651 | -2611 |
| FCF1 | 1633 | -2675 |
| FTSJ3 | -1200 | -670 |
| GNL3 | -2859 | -1419 |
| HEATR1 | -3738 | -1985 |
| IMP3 | -3288 | 99 |
| IMP4 | -4084 | -2925 |
| ISG20L2 | 1309 | 1893 |
| KRR1 | -2907 | -6562 |
| LTV1 | -1284 | -3205 |
| MPHOSPH10 | -2537 | -57 |
| MPHOSPH6 | 685 | -5463 |
| NCL | -3204 | -2515 |
| NIP7 | -1813 | -1760 |
| NOB1 | -3724 | -1000 |
| NOC4L | -1668 | 1990 |
| NOL11 | -3807 | -2629 |
| NOL12 | 1851 | 505 |
| NOL6 | -4043 | 526 |
| NOL9 | -3670 | 1426 |
| NOP14 | -4022 | 2384 |
| NOP56 | -4540 | -523 |
| NOP58 | -3529 | -2406 |
| PDCD11 | -4401 | -2174 |
| PELP1 | -4054 | -1579 |
| PES1 | -609 | -3908 |
| PNO1 | -2170 | -5495 |
| PWP2 | -378 | 681 |
| RBM28 | -4493 | -685 |
| RCL1 | -244 | -1421 |
| RIOK1 | -1131 | -2098 |
| RIOK2 | 300 | -954 |
| RIOK3 | 4013 | -2443 |
| RPL10A | -2096 | -648 |
| RPL11 | -1944 | -2771 |
| RPL13 | -1024 | -191 |
| RPL13A | -2727 | 1802 |
| RPL14 | -2104 | -100 |
| RPL15 | -313 | -4694 |
| RPL17 | -1654 | 1099 |
| RPL18 | -1546 | -2031 |
| RPL18A | -1876 | -4966 |
| RPL22 | -1434 | -3996 |
| RPL23 | -990 | -566 |
| RPL23A | -3334 | 1843 |
| RPL26 | -2060 | -1489 |
| RPL26L1 | 3079 | -2860 |
| RPL27A | -1942 | -55 |
| RPL28 | -456 | -3478 |
| RPL29 | -1075 | 305 |
| RPL3 | -2885 | 2313 |
| RPL31 | -1362 | -2278 |
| RPL32 | -2103 | 1928 |
| RPL34 | -2147 | -3159 |
| RPL35 | -2671 | 952 |
| RPL36 | -1614 | 4 |
| RPL36AL | 9 | 1901 |
| RPL37 | -1982 | -126 |
| RPL37A | -1178 | 211 |
| RPL38 | -1800 | -818 |
| RPL39L | -2993 | -329 |
| RPL4 | -1064 | 2321 |
| RPL41 | -2172 | -229 |
| RPL6 | -999 | 474 |
| RPL7 | -589 | -6019 |
| RPL8 | -373 | -5267 |
| RPL9 | -566 | 741 |
| RPLP0 | -320 | -185 |
| RPLP1 | 3 | -4053 |
| RPLP2 | -2265 | 579 |
| RPP14 | 974 | -354 |
| RPP21 | -1631 | -5256 |
| RPP25 | -2741 | -5917 |
| RPP30 | -2675 | -5522 |
| RPP38 | -2263 | 1598 |
| RPP40 | -1467 | -1426 |
| RPS10 | -1780 | 1246 |
| RPS11 | -2332 | 2115 |
| RPS12 | -1841 | -379 |
| RPS15 | -1095 | 1808 |
| RPS15A | -1762 | 1086 |
| RPS16 | -1410 | 1043 |
| RPS18 | -2520 | -3281 |
| RPS19 | -2212 | -4563 |
| RPS2 | -1344 | 2392 |
| RPS20 | -3028 | -1962 |
| RPS23 | -1958 | -1981 |
| RPS24 | -87 | -2012 |
| RPS25 | -1980 | 254 |
| RPS26 | -446 | -3094 |
| RPS27A | -2201 | -2138 |
| RPS27L | 649 | -2218 |
| RPS28 | -1426 | 525 |
| RPS29 | -2606 | -159 |
| RPS3 | -1822 | -632 |
| RPS3A | -1419 | 1275 |
| RPS5 | -1744 | -1026 |
| RPS6 | -1906 | -1785 |
| RPS7 | -1509 | -2594 |
| RPS8 | -627 | 1886 |
| RPS9 | 2097 | 139 |
| RPSA | -1968 | -1486 |
| RRP1 | -924 | 77 |
| RRP7A | -846 | -2961 |
| RRP9 | -3589 | 2034 |
| SENP3 | 966 | -1248 |
| SNU13 | -2174 | 1961 |
| TBL3 | -1027 | 994 |
| TEX10 | -3427 | -1947 |
| TSR1 | -3410 | -3041 |
| UBA52 | 349 | 752 |
| UTP15 | -3872 | -2796 |
| UTP18 | 1940 | -3819 |
| UTP20 | -3834 | -1372 |
| UTP3 | -874 | -3665 |
| UTP6 | -1347 | -1904 |
| WDR12 | 1988 | 706 |
| WDR18 | -691 | -2042 |
| WDR3 | -2064 | -5710 |
| WDR36 | -1177 | -2277 |
| WDR43 | -2494 | -4225 |
| WDR75 | -3509 | 1028 |
| XRN2 | 4366 | -5589 |
Platelet activation, signaling and aggregation
| metric | value |
|---|---|
| setSize | 133 |
| pMANOVA | 1.35e-08 |
| p.adjustMANOVA | 2.9e-08 |
| s.dist | 0.297 |
| s.RNA | 0.291 |
| s.meth | 0.0625 |
| p.RNA | 8.09e-09 |
| p.meth | 0.215 |
| Gene | RNA | meth |
|---|---|---|
| ACTN1 | 4201 | 2335 |
| DGKG | 3539 | 2259 |
| GNG5 | 4043 | 1920 |
| WDR1 | 2948 | 2364 |
| MAPK1 | 3249 | 1865 |
| RHOA | 3753 | 1313 |
| PTPN1 | 2254 | 2074 |
| CALU | 3497 | 1252 |
| RAC1 | 4031 | 971 |
| CFL1 | 3683 | 912 |
| RHOG | 3858 | 860 |
| PRKCD | 4154 | 584 |
| PFN1 | 2119 | 833 |
| CSK | 1990 | 862 |
| MANF | 813 | 1947 |
| PTK2 | 1629 | 920 |
| YWHAZ | 2200 | 541 |
| RAP1A | 3148 | 323 |
| TLN1 | 3876 | 191 |
| GNG3 | 285 | 2231 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| A1BG | 2170 | -3533 |
| AAMP | -1084 | -5298 |
| ABCC4 | 3217 | -3153 |
| ABHD12 | -3773 | -129 |
| ABHD6 | -854 | -284 |
| ACTN1 | 4201 | 2335 |
| ACTN4 | 1907 | -2928 |
| AKT1 | 1234 | -1942 |
| ALDOA | 4285 | -1349 |
| ANXA5 | 3692 | -2845 |
| APBB1IP | 4003 | -5120 |
| APLP2 | 4343 | -3465 |
| APP | 4249 | -5300 |
| ARRB1 | 632 | -6363 |
| ARRB2 | 3860 | -2243 |
| BRPF3 | -2062 | -937 |
| CALM1 | -626 | -5019 |
| CALU | 3497 | 1252 |
| CAP1 | 3635 | -553 |
| CD63 | 4308 | -1017 |
| CDC37L1 | -2853 | 1097 |
| CDC42 | 3268 | -2719 |
| CFL1 | 3683 | 912 |
| CHID1 | 909 | -254 |
| CRK | 4091 | -4581 |
| CSK | 1990 | 862 |
| CYB5R1 | 4394 | -1352 |
| DAGLB | 2303 | -6635 |
| DGKA | -2629 | 2375 |
| DGKD | -162 | 546 |
| DGKE | -4323 | -953 |
| DGKG | 3539 | 2259 |
| DGKH | -953 | -6190 |
| DGKQ | -2697 | 1446 |
| DGKZ | -1742 | -6294 |
| ENDOD1 | 1124 | -4107 |
| FAM3C | -3576 | 527 |
| FERMT3 | 4270 | -1343 |
| FYN | -4495 | 1957 |
| GNA12 | 1128 | -3386 |
| GNA13 | 2310 | -2285 |
| GNA15 | 4391 | -6690 |
| GNAI2 | 3616 | -1747 |
| GNAI3 | 3536 | -909 |
| GNAQ | 4145 | -6733 |
| GNB1 | 3736 | -2920 |
| GNB2 | 3650 | -309 |
| GNB4 | 3163 | -6007 |
| GNB5 | 163 | 1821 |
| GNG2 | -2538 | -3847 |
| GNG3 | 285 | 2231 |
| GNG4 | -649 | 2073 |
| GNG5 | 4043 | 1920 |
| GNG7 | -1581 | -4773 |
| GNGT2 | -4735 | 2438 |
| GRB2 | 4320 | -2295 |
| GTPBP2 | 2582 | -487 |
| HABP4 | -4052 | 230 |
| ITPR1 | -2478 | -3278 |
| ITPR2 | 2315 | -6107 |
| ITPR3 | -3717 | -3427 |
| LCK | -4596 | 2489 |
| LCP2 | -363 | 1588 |
| MANF | 813 | 1947 |
| MAPK1 | 3249 | 1865 |
| MAPK14 | 4207 | -3529 |
| MAPK3 | 4121 | -2448 |
| NHLRC2 | -2558 | -716 |
| OLA1 | 1835 | -508 |
| P2RY1 | 3468 | -5377 |
| PCYOX1L | -605 | 339 |
| PDPK1 | 2474 | 167 |
| PFN1 | 2119 | 833 |
| PHACTR2 | 2092 | -6672 |
| PIK3CA | 1703 | -1445 |
| PIK3CG | 569 | -2045 |
| PIK3R1 | -3307 | 2310 |
| PIK3R2 | 1887 | -1223 |
| PIK3R3 | -4692 | -22 |
| PIK3R5 | -688 | 514 |
| PLCG2 | 1884 | -2562 |
| PLEK | 633 | -5891 |
| PPIA | -2133 | 490 |
| PRKCA | 356 | 810 |
| PRKCB | 3029 | -4518 |
| PRKCD | 4154 | 584 |
| PRKCE | -2638 | -5632 |
| PRKCH | -4868 | 1376 |
| PRKCQ | -4762 | 1372 |
| PRKCZ | -4470 | -5220 |
| PSAP | 3061 | -4192 |
| PTK2 | 1629 | 920 |
| PTPN1 | 2254 | 2074 |
| PTPN11 | 2038 | -2302 |
| PTPN6 | 2452 | -4586 |
| QSOX1 | 4315 | -1087 |
| RAC1 | 4031 | 971 |
| RAC2 | 1962 | -868 |
| RAF1 | 3488 | -314 |
| RAP1A | 3148 | 323 |
| RAP1B | 1058 | -1031 |
| RASGRP1 | -4668 | 2119 |
| RASGRP2 | -2873 | 1508 |
| RHOA | 3753 | 1313 |
| RHOB | 390 | -4992 |
| RHOG | 3858 | 860 |
| SCCPDH | 3431 | -5477 |
| SHC1 | 1472 | -2954 |
| SOD1 | -1475 | -1019 |
| SOS1 | -1748 | -6775 |
| SRC | -2999 | -4427 |
| SRGN | 4011 | -2722 |
| STX4 | 189 | -6001 |
| STXBP2 | 4170 | -6352 |
| STXBP3 | 3212 | -1306 |
| SYK | 4192 | -5054 |
| TAGLN2 | 3178 | -1136 |
| TEX264 | -2805 | 55 |
| TGFB1 | 1959 | -6 |
| TGFB2 | -2429 | -6761 |
| TGFB3 | -2583 | -5946 |
| TLN1 | 3876 | 191 |
| TMX3 | -249 | -6313 |
| TOR4A | 4072 | -6704 |
| TUBA4A | 2678 | -4571 |
| VAV1 | 3499 | -3184 |
| VAV2 | -1214 | -643 |
| VAV3 | 1824 | -6342 |
| VCL | 3157 | -5870 |
| VEGFA | 3235 | -2723 |
| VTI1B | 4065 | -359 |
| WDR1 | 2948 | 2364 |
| YWHAZ | 2200 | 541 |
Metabolism of RNA
| metric | value |
|---|---|
| setSize | 535 |
| pMANOVA | 6.68e-08 |
| p.adjustMANOVA | 1.21e-07 |
| s.dist | 0.153 |
| s.RNA | -0.0918 |
| s.meth | 0.123 |
| p.RNA | 0.000355 |
| p.meth | 1.72e-06 |
| Gene | RNA | meth |
|---|---|---|
| NOP14 | -4022 | 2384 |
| RNMT | -4139 | 2172 |
| WDR77 | -3675 | 2308 |
| UPF3A | -3462 | 2175 |
| RRP9 | -3589 | 2034 |
| RPL3 | -2885 | 2313 |
| SRSF7 | -3031 | 2075 |
| MTERF4 | -4033 | 1559 |
| RPL23A | -3334 | 1843 |
| ADAT1 | -3158 | 1883 |
| NUP43 | -3314 | 1617 |
| EXOSC2 | -4132 | 1269 |
| NOL9 | -3670 | 1426 |
| FUS | -2274 | 2205 |
| RPS11 | -2332 | 2115 |
| RPL13A | -2727 | 1802 |
| TTC37 | -2287 | 2107 |
| FAM98B | -2732 | 1741 |
| SRSF2 | -1991 | 2284 |
| SF3A3 | -3953 | 1130 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAAS | -2812 | 405 |
| ACTB | 4156 | -4515 |
| ADAR | -1029 | -263 |
| ADARB1 | -1667 | -6225 |
| ADAT1 | -3158 | 1883 |
| ADAT2 | -3526 | -2393 |
| ADAT3 | 347 | 1001 |
| AKT1 | 1234 | -1942 |
| ALKBH8 | -4457 | -3991 |
| ALYREF | 2102 | -4902 |
| ANP32A | 3747 | -3737 |
| AQR | 574 | -336 |
| BMS1 | -4492 | -2552 |
| BUD31 | 3007 | 776 |
| BYSL | -1331 | -88 |
| C1D | 1194 | 510 |
| C2orf49 | -1785 | -443 |
| CASC3 | 2005 | -2580 |
| CCAR1 | -721 | -2951 |
| CCNH | 243 | -3754 |
| CD2BP2 | -635 | -6240 |
| CD44 | 3760 | 266 |
| CDC40 | 2845 | 2242 |
| CDC5L | 2311 | -5959 |
| CDK7 | 1983 | 275 |
| CDKAL1 | -3155 | -2998 |
| CHERP | -1548 | -2459 |
| CLNS1A | 366 | -1163 |
| CLP1 | 2730 | -1417 |
| CNOT1 | -1273 | -4543 |
| CNOT10 | -811 | -361 |
| CNOT11 | 663 | -2236 |
| CNOT3 | 2042 | 565 |
| CNOT4 | -399 | -3064 |
| CNOT6 | 1783 | -3728 |
| CNOT6L | -4229 | -5686 |
| CNOT7 | -1154 | 349 |
| CNOT8 | 3701 | -2054 |
| CPSF1 | -1130 | -6284 |
| CPSF2 | 3459 | -3164 |
| CPSF3 | 2740 | -4860 |
| CPSF4 | -3261 | 134 |
| CRNKL1 | 1509 | 433 |
| CSNK1D | 760 | -1777 |
| CSNK1E | -3709 | -4750 |
| CSTF1 | -1891 | 2021 |
| CTNNBL1 | 480 | -2232 |
| CTU1 | 1699 | -3154 |
| CTU2 | -3058 | -2262 |
| CWC15 | -692 | -4721 |
| CWC22 | 261 | -3308 |
| CWC27 | 1621 | 2224 |
| DCAF13 | -1698 | -2001 |
| DCP1A | -1657 | -2482 |
| DCP1B | -4482 | -5406 |
| DCP2 | 2848 | -2783 |
| DCPS | -700 | -1076 |
| DDX1 | -840 | -558 |
| DDX20 | -4044 | -3695 |
| DDX21 | 1018 | 760 |
| DDX23 | -218 | 164 |
| DDX42 | 7 | -1996 |
| DDX46 | 814 | -2306 |
| DDX47 | -4257 | -3056 |
| DDX49 | 1815 | -4408 |
| DDX5 | -3465 | 1288 |
| DDX52 | 142 | -1954 |
| DDX6 | -580 | 1106 |
| DHX16 | -1503 | -3824 |
| DHX37 | -2753 | -312 |
| DHX9 | 322 | 871 |
| DIS3 | -1292 | -762 |
| DNAJC8 | 334 | 605 |
| DUS2 | 1175 | 2247 |
| EBNA1BP2 | -1224 | 1600 |
| EDC3 | 1313 | -1960 |
| EDC4 | -1557 | -5349 |
| EFTUD2 | 3773 | 1095 |
| EIF4A1 | 3303 | -3762 |
| EIF4A2 | -4175 | 836 |
| EIF4A3 | 3132 | -3850 |
| EIF4B | 387 | -4336 |
| EIF4E | 1789 | 1536 |
| EIF4G1 | 3585 | 746 |
| ELAC2 | -4545 | -916 |
| ELAVL1 | 651 | -6154 |
| ENPP2 | 603 | -2276 |
| ERCC2 | 1210 | -594 |
| ERCC3 | -2534 | 969 |
| ERI1 | 2157 | 130 |
| ETF1 | 3209 | 758 |
| EXOSC1 | -319 | -290 |
| EXOSC10 | -4315 | -1580 |
| EXOSC2 | -4132 | 1269 |
| EXOSC3 | 161 | -2555 |
| EXOSC4 | 3305 | -4410 |
| EXOSC5 | -1377 | 1591 |
| EXOSC6 | -3464 | 545 |
| EXOSC7 | -3889 | -4665 |
| EXOSC8 | -4363 | 1020 |
| FAM98B | -2732 | 1741 |
| FAU | -124 | -3862 |
| FBL | -3651 | -2611 |
| FCF1 | 1633 | -2675 |
| FIP1L1 | -2603 | -2274 |
| FTSJ3 | -1200 | -670 |
| FUS | -2274 | 2205 |
| FYTTD1 | -1781 | 1459 |
| GAR1 | -2203 | -4416 |
| GCFC2 | -3981 | -2094 |
| GEMIN2 | -2496 | -3548 |
| GEMIN4 | -4181 | -6519 |
| GEMIN5 | -1560 | -2833 |
| GEMIN6 | 745 | -1619 |
| GEMIN7 | 1801 | 1324 |
| GLE1 | 1950 | 829 |
| GNL3 | -2859 | -1419 |
| GSPT1 | 2672 | -4456 |
| GTF2F1 | 1854 | -1723 |
| GTF2F2 | 2104 | -2885 |
| GTF2H3 | -672 | 1025 |
| GTF2H4 | -876 | -2761 |
| GTF2H5 | 1345 | 691 |
| GTPBP3 | -2334 | -3838 |
| HBS1L | 1873 | -598 |
| HEATR1 | -3738 | -1985 |
| HNRNPA0 | -2960 | 460 |
| HNRNPA2B1 | 1133 | -2665 |
| HNRNPC | 2536 | -1112 |
| HNRNPD | 902 | -1374 |
| HNRNPF | 1366 | -58 |
| HNRNPH1 | -2604 | -1020 |
| HNRNPK | 3259 | -2386 |
| HNRNPL | -34 | -741 |
| HNRNPM | 1976 | -4945 |
| HNRNPR | -2856 | -4296 |
| HNRNPU | 928 | -970 |
| HNRNPUL1 | 935 | -1966 |
| HSPA1A | 3613 | -3825 |
| HSPB1 | 582 | -4137 |
| IGF2BP3 | 2588 | -4480 |
| IMP3 | -3288 | 99 |
| IMP4 | -4084 | -2925 |
| ISG20L2 | 1309 | 1893 |
| ISY1 | 2281 | -4700 |
| KHSRP | 866 | -5005 |
| KRR1 | -2907 | -6562 |
| LCMT2 | -3932 | -441 |
| LSM1 | 2464 | 515 |
| LSM10 | 2585 | -3871 |
| LSM11 | -3779 | -4172 |
| LSM2 | 860 | -1678 |
| LSM3 | -133 | -674 |
| LSM4 | -3824 | -5491 |
| LSM5 | -1952 | -3381 |
| LSM6 | 3069 | -1989 |
| LSM7 | -2063 | -5454 |
| LSM8 | -3316 | -2296 |
| LTV1 | -1284 | -3205 |
| MAPK14 | 4207 | -3529 |
| MAPKAPK2 | 1428 | 2012 |
| METTL1 | -2291 | -5208 |
| METTL14 | -2292 | -4236 |
| MNAT1 | -2935 | 311 |
| MPHOSPH10 | -2537 | -57 |
| MPHOSPH6 | 685 | -5463 |
| MRM1 | -3829 | -5990 |
| MTERF4 | -4033 | 1559 |
| MTO1 | -2811 | -856 |
| NCBP1 | -1807 | -3745 |
| NCBP2 | -3329 | -4067 |
| NCL | -3204 | -2515 |
| NDC1 | -4789 | -5228 |
| NHP2 | -1038 | -260 |
| NIP7 | -1813 | -1760 |
| NOB1 | -3724 | -1000 |
| NOC4L | -1668 | 1990 |
| NOL11 | -3807 | -2629 |
| NOL12 | 1851 | 505 |
| NOL6 | -4043 | 526 |
| NOL9 | -3670 | 1426 |
| NOP10 | 3759 | -3526 |
| NOP14 | -4022 | 2384 |
| NOP2 | -3530 | -2438 |
| NOP56 | -4540 | -523 |
| NOP58 | -3529 | -2406 |
| NSUN2 | -570 | 65 |
| NSUN4 | -1451 | -3469 |
| NSUN6 | -2512 | -2844 |
| NUDT21 | -1100 | 13 |
| NUP107 | -3782 | -1197 |
| NUP133 | -2528 | 112 |
| NUP153 | -1967 | 834 |
| NUP155 | -3676 | -4352 |
| NUP160 | -3847 | 763 |
| NUP188 | -4466 | -847 |
| NUP205 | -4274 | 826 |
| NUP210 | -3943 | 910 |
| NUP214 | 3517 | 1119 |
| NUP35 | -3878 | -321 |
| NUP37 | 998 | -1886 |
| NUP43 | -3314 | 1617 |
| NUP50 | 1650 | 1760 |
| NUP54 | -2855 | -2767 |
| NUP62 | 242 | -980 |
| NUP85 | -912 | 317 |
| NUP88 | -4326 | -128 |
| NUP93 | -4463 | -3462 |
| NUP98 | 1012 | 315 |
| NXF1 | 563 | -162 |
| NXT1 | -2554 | 1069 |
| PABPC1 | 2061 | -2769 |
| PABPN1 | -169 | -3743 |
| PAIP1 | 927 | 241 |
| PAN2 | -1320 | -1449 |
| PAN3 | 2 | -3562 |
| PAPOLA | 3065 | 775 |
| PARN | -1591 | -4138 |
| PATL1 | 2054 | -5336 |
| PCBP1 | 3284 | -1395 |
| PCBP2 | 2027 | 132 |
| PDCD11 | -4401 | -2174 |
| PDCD7 | -2408 | -1270 |
| PELP1 | -4054 | -1579 |
| PES1 | -609 | -3908 |
| PHAX | -1605 | 694 |
| PLRG1 | -2109 | 692 |
| PNO1 | -2170 | -5495 |
| PNRC2 | -1366 | -2821 |
| POLDIP3 | 3131 | -5416 |
| POLR2A | -928 | -3832 |
| POLR2B | -751 | 926 |
| POLR2C | 501 | 1027 |
| POLR2D | -1201 | -2419 |
| POLR2E | 3283 | -1584 |
| POLR2F | 1692 | -4483 |
| POLR2G | 1190 | -2402 |
| POLR2H | -882 | 1944 |
| POLR2I | 123 | -5210 |
| POLR2K | -537 | -2424 |
| POM121 | -2766 | -1787 |
| POM121C | -2305 | -4315 |
| POP1 | -1211 | -517 |
| POP4 | -1125 | 2076 |
| POP5 | -3385 | -4690 |
| POP7 | 1464 | 466 |
| PPIE | -3082 | 644 |
| PPIH | -4434 | -2541 |
| PPIL1 | -1715 | -5540 |
| PPIL3 | -1533 | -1459 |
| PPIL4 | 995 | -2414 |
| PPIL6 | 85 | 1558 |
| PPP2CA | 3707 | 300 |
| PPP2R2A | 1461 | -5074 |
| PPWD1 | -3767 | 513 |
| PRCC | 780 | -2557 |
| PRKCA | 356 | 810 |
| PRKCD | 4154 | 584 |
| PRMT5 | 1232 | -2112 |
| PRPF19 | -3026 | -2289 |
| PRPF3 | -2461 | -5317 |
| PRPF31 | -2436 | -4737 |
| PRPF38A | -70 | -2763 |
| PRPF40A | 898 | 2454 |
| PRPF6 | -2246 | -2317 |
| PRPF8 | -2680 | -1872 |
| PSMA1 | 3158 | -1782 |
| PSMA2 | 2052 | 1205 |
| PSMA3 | -1612 | -2824 |
| PSMA5 | -1869 | 592 |
| PSMA6 | 2386 | -1838 |
| PSMA7 | 3028 | 1752 |
| PSMB1 | 1131 | -1179 |
| PSMB10 | -1758 | -4718 |
| PSMB2 | 1439 | 2355 |
| PSMB3 | 3076 | -2678 |
| PSMB5 | 3630 | -4604 |
| PSMB6 | 2854 | -3576 |
| PSMB7 | 3856 | -2038 |
| PSMB8 | -921 | 1189 |
| PSMB9 | -4276 | -1453 |
| PSMC1 | 2977 | -5705 |
| PSMC3 | 624 | -4615 |
| PSMC4 | -3133 | 1003 |
| PSMC5 | -287 | -3263 |
| PSMC6 | 2757 | -5508 |
| PSMD1 | 3112 | 1660 |
| PSMD11 | 2532 | -2152 |
| PSMD12 | 2710 | 1314 |
| PSMD13 | 2376 | 1328 |
| PSMD14 | 836 | -2484 |
| PSMD2 | 3204 | -85 |
| PSMD3 | 1696 | -4331 |
| PSMD4 | 3806 | -4683 |
| PSMD6 | 3465 | -5488 |
| PSMD7 | 2383 | 7 |
| PSMD8 | 2270 | -3290 |
| PSMD9 | 3321 | -2041 |
| PSME1 | -3548 | -2343 |
| PSME2 | -3731 | -2364 |
| PSME3 | 3715 | 1116 |
| PSME4 | -1884 | -3380 |
| PSMF1 | 2775 | -4867 |
| PTBP1 | -68 | -1843 |
| PUF60 | -270 | 1796 |
| PUS1 | -1988 | -1746 |
| PUS3 | 1246 | -5241 |
| PUS7 | -1663 | 263 |
| PWP2 | -378 | 681 |
| QTRT1 | -3345 | -3239 |
| RAE1 | 1963 | -39 |
| RAN | -2142 | 1257 |
| RANBP2 | -273 | -4704 |
| RBM17 | -1486 | 1681 |
| RBM28 | -4493 | -685 |
| RCL1 | -244 | -1421 |
| RIOK1 | -1131 | -2098 |
| RIOK2 | 300 | -954 |
| RIOK3 | 4013 | -2443 |
| RNGTT | 1007 | -2952 |
| RNMT | -4139 | 2172 |
| RNPC3 | -1313 | -1410 |
| RNPS1 | -4345 | -3160 |
| RPL10A | -2096 | -648 |
| RPL11 | -1944 | -2771 |
| RPL13 | -1024 | -191 |
| RPL13A | -2727 | 1802 |
| RPL14 | -2104 | -100 |
| RPL15 | -313 | -4694 |
| RPL17 | -1654 | 1099 |
| RPL18 | -1546 | -2031 |
| RPL18A | -1876 | -4966 |
| RPL22 | -1434 | -3996 |
| RPL23 | -990 | -566 |
| RPL23A | -3334 | 1843 |
| RPL26 | -2060 | -1489 |
| RPL26L1 | 3079 | -2860 |
| RPL27A | -1942 | -55 |
| RPL28 | -456 | -3478 |
| RPL29 | -1075 | 305 |
| RPL3 | -2885 | 2313 |
| RPL31 | -1362 | -2278 |
| RPL32 | -2103 | 1928 |
| RPL34 | -2147 | -3159 |
| RPL35 | -2671 | 952 |
| RPL36 | -1614 | 4 |
| RPL36AL | 9 | 1901 |
| RPL37 | -1982 | -126 |
| RPL37A | -1178 | 211 |
| RPL38 | -1800 | -818 |
| RPL39L | -2993 | -329 |
| RPL4 | -1064 | 2321 |
| RPL41 | -2172 | -229 |
| RPL6 | -999 | 474 |
| RPL7 | -589 | -6019 |
| RPL8 | -373 | -5267 |
| RPL9 | -566 | 741 |
| RPLP0 | -320 | -185 |
| RPLP1 | 3 | -4053 |
| RPLP2 | -2265 | 579 |
| RPP14 | 974 | -354 |
| RPP21 | -1631 | -5256 |
| RPP25 | -2741 | -5917 |
| RPP30 | -2675 | -5522 |
| RPP38 | -2263 | 1598 |
| RPP40 | -1467 | -1426 |
| RPPH1 | 25 | -5149 |
| RPS10 | -1780 | 1246 |
| RPS11 | -2332 | 2115 |
| RPS12 | -1841 | -379 |
| RPS15 | -1095 | 1808 |
| RPS15A | -1762 | 1086 |
| RPS16 | -1410 | 1043 |
| RPS18 | -2520 | -3281 |
| RPS19 | -2212 | -4563 |
| RPS2 | -1344 | 2392 |
| RPS20 | -3028 | -1962 |
| RPS23 | -1958 | -1981 |
| RPS24 | -87 | -2012 |
| RPS25 | -1980 | 254 |
| RPS26 | -446 | -3094 |
| RPS27A | -2201 | -2138 |
| RPS27L | 649 | -2218 |
| RPS28 | -1426 | 525 |
| RPS29 | -2606 | -159 |
| RPS3 | -1822 | -632 |
| RPS3A | -1419 | 1275 |
| RPS5 | -1744 | -1026 |
| RPS6 | -1906 | -1785 |
| RPS7 | -1509 | -2594 |
| RPS8 | -627 | 1886 |
| RPS9 | 2097 | 139 |
| RPSA | -1968 | -1486 |
| RRP1 | -924 | 77 |
| RRP7A | -846 | -2961 |
| RRP9 | -3589 | 2034 |
| RTCB | -461 | -261 |
| SART1 | 1259 | 218 |
| SEC13 | 2266 | -3749 |
| SEH1L | -1875 | -1615 |
| SENP3 | 966 | -1248 |
| SET | -2218 | -5937 |
| SF1 | -215 | -1708 |
| SF3A1 | -726 | -2997 |
| SF3A2 | -1608 | 2430 |
| SF3A3 | -3953 | 1130 |
| SF3B2 | 568 | -3350 |
| SF3B3 | -3425 | -1675 |
| SF3B4 | 708 | 984 |
| SF3B5 | 1093 | -4116 |
| SKIV2L | -1017 | -2116 |
| SLBP | 2050 | -327 |
| SLU7 | 871 | -3467 |
| SMG1 | -1341 | -3377 |
| SMG5 | 2044 | -4423 |
| SMG6 | -1937 | 1909 |
| SMG7 | 2744 | -589 |
| SMG8 | 939 | -3537 |
| SMNDC1 | 2212 | -3187 |
| SNRNP200 | -4136 | -2478 |
| SNRNP25 | -33 | 2102 |
| SNRNP27 | 2692 | 1474 |
| SNRNP35 | 1678 | -3130 |
| SNRNP40 | -3737 | -1247 |
| SNRNP48 | -384 | 996 |
| SNRNP70 | -2059 | -371 |
| SNRPA | 791 | 1121 |
| SNRPA1 | -3561 | -3336 |
| SNRPB | -718 | -2182 |
| SNRPB2 | 1056 | -5774 |
| SNRPC | 234 | -3668 |
| SNRPD1 | 208 | -1771 |
| SNRPD2 | -2510 | 1134 |
| SNRPD3 | 518 | 1486 |
| SNRPE | 194 | -919 |
| SNRPG | 512 | -4002 |
| SNRPN | -3514 | -5234 |
| SNU13 | -2174 | 1961 |
| SNUPN | 2439 | -2979 |
| SNW1 | 1979 | 946 |
| SRRM1 | -1535 | -2963 |
| SRRM2 | -853 | 2142 |
| SRRT | -1601 | -3758 |
| SRSF10 | -2779 | 1198 |
| SRSF11 | -3554 | -5151 |
| SRSF2 | -1991 | 2284 |
| SRSF3 | -682 | -121 |
| SRSF4 | 1324 | -2328 |
| SRSF7 | -3031 | 2075 |
| SRSF9 | 3210 | -3686 |
| SUPT5H | -2108 | -3641 |
| SYF2 | 1899 | -1707 |
| SYMPK | -1895 | -2815 |
| TBL3 | -1027 | 994 |
| TEX10 | -3427 | -1947 |
| TFB1M | -4290 | -3739 |
| TFIP11 | 151 | -278 |
| THADA | -4547 | -3826 |
| THG1L | -3813 | -2349 |
| THOC1 | -3681 | 73 |
| THOC5 | 3107 | 747 |
| THOC7 | 2564 | -369 |
| THUMPD1 | -3443 | -4292 |
| TNFSF13 | 3783 | -5904 |
| TNKS1BP1 | -1672 | -5457 |
| TNPO1 | 1436 | -1546 |
| TP53RK | -4708 | -2342 |
| TPR | -2242 | -973 |
| TPRKB | -1590 | -2506 |
| TRDMT1 | 290 | -4357 |
| TRIT1 | 238 | -2615 |
| TRMT1 | -1030 | 1178 |
| TRMT10A | 2892 | -5299 |
| TRMT11 | -4226 | -4066 |
| TRMT112 | 233 | -4666 |
| TRMT12 | -109 | 956 |
| TRMT44 | -2179 | -1269 |
| TRMT6 | 2240 | 1951 |
| TRMT61A | -3328 | -4239 |
| TRMT61B | -2628 | -2862 |
| TRMU | -3201 | -1879 |
| TRNT1 | -2449 | -1006 |
| TSEN15 | -3498 | -3075 |
| TSEN2 | -4059 | -3251 |
| TSEN34 | 3254 | -751 |
| TSEN54 | -4841 | -550 |
| TSR1 | -3410 | -3041 |
| TSR3 | 1337 | 1167 |
| TTC37 | -2287 | 2107 |
| TXNL4A | 2929 | -1664 |
| TYW1 | -3175 | -820 |
| TYW3 | -2782 | -4913 |
| TYW5 | -381 | 485 |
| U2AF1 | 398 | -5640 |
| U2AF1L4 | -1283 | 2171 |
| U2AF2 | 1256 | -306 |
| U2SURP | -1927 | -4877 |
| UBA52 | 349 | 752 |
| UBB | 2759 | -1321 |
| UBC | 1618 | -2568 |
| UPF1 | 1731 | -630 |
| UPF2 | 307 | -1572 |
| UPF3A | -3462 | 2175 |
| URM1 | -360 | -3584 |
| USP39 | 1448 | 117 |
| UTP15 | -3872 | -2796 |
| UTP18 | 1940 | -3819 |
| UTP20 | -3834 | -1372 |
| UTP3 | -874 | -3665 |
| UTP6 | -1347 | -1904 |
| WBP11 | -4480 | -1693 |
| WBP4 | 2071 | -3514 |
| WDR12 | 1988 | 706 |
| WDR18 | -691 | -2042 |
| WDR3 | -2064 | -5710 |
| WDR33 | -2506 | -3224 |
| WDR36 | -1177 | -2277 |
| WDR43 | -2494 | -4225 |
| WDR61 | 22 | -4752 |
| WDR75 | -3509 | 1028 |
| WDR77 | -3675 | 2308 |
| WTAP | 1550 | -525 |
| XAB2 | -567 | -1877 |
| XPO1 | -371 | -870 |
| XPOT | -809 | -828 |
| XRN1 | -2146 | -5555 |
| XRN2 | 4366 | -5589 |
| YBX1 | 1010 | -364 |
| YWHAB | 2611 | 2125 |
| YWHAZ | 2200 | 541 |
| ZBTB8OS | 1520 | -1338 |
| ZCRB1 | 150 | 2291 |
| ZFP36 | 2933 | 1924 |
| ZFP36L1 | 2944 | 784 |
| ZMAT5 | 2765 | -6365 |
Metabolism of lipids
| metric | value |
|---|---|
| setSize | 427 |
| pMANOVA | 7.26e-08 |
| p.adjustMANOVA | 1.21e-07 |
| s.dist | 0.164 |
| s.RNA | 0.164 |
| s.meth | -0.00959 |
| p.RNA | 9.91e-09 |
| p.meth | 0.737 |
| Gene | RNA | meth |
|---|---|---|
| GGT1 | 4376 | -6607 |
| TSPO | 4344 | -6553 |
| PTGR1 | 4217 | -6711 |
| ARF1 | 4184 | -6686 |
| TBXAS1 | 4073 | -6709 |
| PRKACA | 4378 | -6032 |
| PLD1 | 4321 | -6058 |
| ALOX5 | 4150 | -6082 |
| CHPT1 | 4062 | -5900 |
| GPX1 | 4327 | -5467 |
| PNPLA2 | 4111 | -5698 |
| ALOX5AP | 3490 | -6710 |
| PGS1 | 3952 | -5906 |
| VAPA | 4169 | -5592 |
| PLB1 | 4405 | -5279 |
| GBA | 4133 | -5623 |
| HEXB | 4022 | -5777 |
| FIG4 | 4210 | -5382 |
| GLTP | 3852 | -5867 |
| LPGAT1 | 3906 | -5760 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AACS | 105 | 843 |
| ABCA1 | 2459 | -6487 |
| ABCC1 | 179 | -871 |
| ABHD3 | 2932 | -4046 |
| ABHD4 | 2638 | -5841 |
| ABHD5 | 3512 | -5560 |
| ACAA1 | 3734 | 1410 |
| ACACA | 2039 | -164 |
| ACACB | -3532 | -4884 |
| ACAD10 | 1792 | -83 |
| ACAD11 | -3656 | -2327 |
| ACADM | -404 | -2163 |
| ACADS | 1543 | -6188 |
| ACAT1 | 2158 | -2579 |
| ACAT2 | -1106 | -2151 |
| ACBD4 | -1346 | -2973 |
| ACBD5 | -398 | -2520 |
| ACBD6 | -4143 | -1414 |
| ACBD7 | 1102 | -5886 |
| ACER2 | 654 | -2800 |
| ACER3 | 4240 | -1641 |
| ACLY | 1961 | -5417 |
| ACOT13 | 2098 | -3113 |
| ACOT7 | -981 | 1021 |
| ACOT8 | 3578 | -2563 |
| ACOX1 | 4070 | -5075 |
| ACOX3 | 2397 | -4725 |
| ACOXL | 1769 | 2527 |
| ACP6 | -1122 | -5222 |
| ACSF2 | -4243 | -5644 |
| ACSF3 | -119 | -5695 |
| ACSL1 | 4266 | -1604 |
| ACSL3 | 3461 | -4285 |
| ACSL5 | -3830 | -215 |
| ACSL6 | -1821 | 2501 |
| ACSM3 | -2384 | -6252 |
| AGK | -4757 | -3004 |
| AGPAT1 | 3663 | 559 |
| AGPAT2 | 4289 | 2250 |
| AGPAT3 | 1787 | -2039 |
| AGPAT4 | -2892 | -4185 |
| AGPAT5 | -3512 | 221 |
| AGPS | 2135 | -3742 |
| AHR | 3240 | 2099 |
| AHRR | -1770 | -702 |
| AKR1B1 | -4638 | 1845 |
| ALDH3A2 | 264 | -2186 |
| ALOX5 | 4150 | -6082 |
| ALOX5AP | 3490 | -6710 |
| AMACR | -2220 | -663 |
| ARF1 | 4184 | -6686 |
| ARF3 | 3396 | -1912 |
| ARNT | 3596 | 1140 |
| ARNTL | -2150 | -4129 |
| ARSA | 1183 | -3099 |
| ARSB | 3290 | -5722 |
| ARSG | -1448 | 152 |
| ARSK | -4182 | -54 |
| ARV1 | -813 | -2677 |
| ASAH1 | 3880 | 335 |
| BDH1 | -3780 | -5778 |
| BDH2 | -4379 | -6434 |
| CAV1 | 619 | -2432 |
| CBR4 | -388 | -2264 |
| CCNC | 589 | -1138 |
| CDIPT | 2525 | -2467 |
| CDK19 | 3319 | -2575 |
| CDK8 | -594 | -5509 |
| CDS2 | 2711 | 979 |
| CEPT1 | 353 | 289 |
| CERK | -1598 | 1601 |
| CERS5 | -758 | -6266 |
| CERS6 | 2291 | -3796 |
| CHD9 | -1380 | -5791 |
| CHKA | 2436 | -4562 |
| CHKB | -992 | 816 |
| CHPT1 | 4062 | -5900 |
| CLOCK | -2411 | -1159 |
| CPNE1 | -1012 | 1274 |
| CPNE3 | 2335 | -2088 |
| CPT1A | 1921 | -6398 |
| CPT2 | 2700 | -6494 |
| CPTP | 1249 | -2096 |
| CRAT | 4098 | -4890 |
| CREBBP | 1153 | -5804 |
| CRLS1 | 4211 | -4654 |
| CSNK1G2 | 284 | -1639 |
| CSNK2A2 | 2614 | -4422 |
| CSNK2B | 1389 | -998 |
| CTSA | 4412 | -4847 |
| CYP2R1 | -3508 | -1915 |
| CYP2U1 | -4687 | -4531 |
| CYP46A1 | -188 | 1529 |
| CYP4F22 | -4840 | -2371 |
| CYP51A1 | 2876 | -5191 |
| DBI | 2529 | 441 |
| DDHD1 | -4459 | 1414 |
| DDHD2 | -4582 | -2861 |
| DECR1 | 2037 | -528 |
| DECR2 | 247 | 830 |
| DEGS1 | 2496 | -193 |
| DGAT1 | 2033 | -6115 |
| DGAT2 | 4236 | -1911 |
| DHCR24 | 858 | -5657 |
| DHCR7 | 2784 | -3544 |
| DHRS7B | 3327 | -3549 |
| DPEP2 | -808 | -6530 |
| ECHS1 | -676 | -1673 |
| ECI1 | 149 | -4832 |
| ECI2 | -4551 | -2127 |
| EHHADH | 2477 | -6438 |
| ELOVL1 | 3022 | -1168 |
| ELOVL4 | -2134 | -2987 |
| ELOVL5 | 2406 | -3408 |
| ELOVL6 | -4374 | -1124 |
| EP300 | 2471 | -4509 |
| EPHX2 | -3649 | -5989 |
| ESRRA | 2372 | -2927 |
| ESYT1 | -4827 | 959 |
| ESYT2 | -4484 | -1193 |
| ETNK1 | -436 | 1286 |
| FABP5 | 2411 | -3534 |
| FADS1 | 3374 | -4312 |
| FADS2 | 458 | -5605 |
| FAM120B | -4 | -2607 |
| FAR1 | 4009 | -224 |
| FASN | -223 | 1100 |
| FDFT1 | 3180 | -4585 |
| FDPS | 2049 | 124 |
| FDX1 | 579 | -3747 |
| FDXR | 1776 | -3448 |
| FIG4 | 4210 | -5382 |
| FITM2 | -1868 | -2082 |
| GALC | 3834 | 264 |
| GBA | 4133 | -5623 |
| GBA2 | 957 | -4419 |
| GDE1 | 3946 | -5040 |
| GDPD1 | -1367 | -1268 |
| GDPD5 | -3955 | -2713 |
| GGPS1 | -339 | -2782 |
| GGT1 | 4376 | -6607 |
| GLB1 | 3992 | 1368 |
| GLIPR1 | 3403 | -2351 |
| GLTP | 3852 | -5867 |
| GM2A | 4180 | -825 |
| GPAM | -3683 | -4630 |
| GPCPD1 | 3878 | -203 |
| GPD1 | -2182 | -6250 |
| GPD1L | -3809 | -2487 |
| GPD2 | 3277 | -6521 |
| GPS2 | -293 | -857 |
| GPX1 | 4327 | -5467 |
| GPX4 | 1957 | -455 |
| GSTM4 | 370 | -4359 |
| HACD1 | 1663 | -4245 |
| HACD2 | -520 | 1513 |
| HACD3 | -4020 | 2329 |
| HACD4 | 2893 | 500 |
| HACL1 | -4541 | -3683 |
| HADH | -4341 | -4809 |
| HADHA | 3974 | 1866 |
| HADHB | 4389 | -968 |
| HDAC3 | 1727 | -3771 |
| HEXA | 391 | -4273 |
| HEXB | 4022 | -5777 |
| HILPDA | -485 | 670 |
| HMGCL | 2059 | 1969 |
| HMGCR | 3626 | -3388 |
| HMGCS1 | -595 | -2608 |
| HPGD | 3208 | -6446 |
| HSD17B1 | 1250 | 1940 |
| HSD17B11 | 3570 | -3328 |
| HSD17B12 | 3082 | -895 |
| HSD17B4 | 4069 | -5528 |
| HSD17B8 | -3941 | 2077 |
| IDI1 | 3116 | 1929 |
| INPP4A | -3365 | 2209 |
| INPP5D | -1207 | -3735 |
| INPP5E | -2803 | 2080 |
| INPP5F | -1476 | 507 |
| INPP5K | -610 | 1585 |
| INPPL1 | 4166 | -2224 |
| INSIG1 | -3893 | 947 |
| INSIG2 | 2643 | -4256 |
| KPNB1 | 776 | -2176 |
| LBR | 3631 | -3506 |
| LCLAT1 | -59 | -2733 |
| LGMN | -1401 | 313 |
| LIPE | -3191 | -5437 |
| LPCAT1 | -2399 | 1540 |
| LPCAT3 | 3925 | -3100 |
| LPCAT4 | -2836 | 1628 |
| LPGAT1 | 3906 | -5760 |
| LPIN1 | -4350 | -2651 |
| LPIN2 | -2200 | 2060 |
| LSS | -3858 | -4805 |
| LTA4H | 4292 | -972 |
| LTC4S | -121 | -6617 |
| MAPKAPK2 | 1428 | 2012 |
| MBOAT1 | 2139 | -4287 |
| MBOAT7 | 3885 | -3703 |
| MBTPS1 | 955 | -398 |
| MCAT | 2113 | -3215 |
| MCEE | -1430 | 320 |
| MECR | -2366 | 350 |
| MED1 | -1206 | -2271 |
| MED10 | -2893 | -2572 |
| MED11 | -181 | 609 |
| MED13 | 807 | 590 |
| MED13L | 2440 | -533 |
| MED15 | -3434 | 2114 |
| MED16 | 2024 | 1719 |
| MED17 | 1004 | -1418 |
| MED18 | 1590 | -186 |
| MED19 | 1074 | -4664 |
| MED20 | 2814 | -542 |
| MED21 | -1826 | -582 |
| MED22 | 1321 | -2059 |
| MED23 | -2139 | 633 |
| MED24 | -2380 | -2701 |
| MED25 | 2518 | -1286 |
| MED26 | 1589 | 18 |
| MED27 | -3167 | -960 |
| MED28 | -445 | 699 |
| MED29 | -2631 | -5128 |
| MED30 | -1669 | 491 |
| MED31 | 447 | 445 |
| MED4 | 1062 | -4472 |
| MED6 | -279 | 560 |
| MED7 | 62 | 778 |
| MED8 | 3267 | 1289 |
| MED9 | -2996 | -3399 |
| MFSD2A | -690 | -5062 |
| MLYCD | -3346 | 97 |
| MMAA | -4375 | -3965 |
| MORC2 | -3367 | 2508 |
| MSMO1 | 818 | 1922 |
| MTF1 | 4102 | -2992 |
| MTMR10 | 3542 | -3555 |
| MTMR12 | -513 | -579 |
| MTMR14 | 3586 | -4278 |
| MTMR2 | -664 | 519 |
| MTMR3 | 4187 | -2340 |
| MTMR4 | 951 | -1420 |
| MTMR6 | 3487 | 1477 |
| MTMR9 | 443 | -2578 |
| MVD | -1805 | 1954 |
| MVK | -2769 | -2474 |
| NCOA2 | 343 | 1407 |
| NCOA3 | 1198 | -2266 |
| NCOA6 | 2280 | -1860 |
| NCOR1 | 2341 | -3738 |
| NCOR2 | 3557 | -4281 |
| NDUFAB1 | 2272 | -395 |
| NEU1 | 4167 | -3878 |
| NEU3 | -1138 | -1409 |
| NFYA | 1189 | 1464 |
| NFYB | -3536 | -531 |
| NFYC | 3345 | -3078 |
| NR1D1 | -3070 | 1187 |
| NR1H2 | 3207 | -1471 |
| NR1H3 | -1069 | -2305 |
| NRF1 | -2712 | -4642 |
| NUDT19 | 2682 | 1908 |
| NUDT7 | 341 | 593 |
| ORMDL1 | -1831 | -584 |
| ORMDL3 | -3550 | -2716 |
| OSBP | -792 | -3696 |
| OSBPL2 | 1941 | -2911 |
| OSBPL3 | -4657 | 375 |
| OSBPL5 | -4802 | -6730 |
| OSBPL7 | -4536 | -4735 |
| OSBPL8 | 2939 | -2735 |
| OSBPL9 | 2623 | -2108 |
| OXCT1 | -4509 | 1553 |
| PCCB | -2627 | -6219 |
| PCTP | 4357 | -3451 |
| PCYT1A | 2857 | 822 |
| PCYT2 | -4291 | -2669 |
| PECR | 4000 | 2064 |
| PEMT | 1014 | -4605 |
| PEX11A | -2998 | -2595 |
| PGS1 | 3952 | -5906 |
| PHOSPHO1 | 947 | -430 |
| PI4K2A | -2085 | -355 |
| PI4K2B | -4673 | -317 |
| PI4KA | -782 | -5 |
| PI4KB | -1333 | 1292 |
| PIAS4 | 1971 | -3982 |
| PIK3CA | 1703 | -1445 |
| PIK3CD | 2422 | 2189 |
| PIK3CG | 569 | -2045 |
| PIK3R1 | -3307 | 2310 |
| PIK3R2 | 1887 | -1223 |
| PIK3R3 | -4692 | -22 |
| PIK3R4 | -1215 | -3425 |
| PIK3R5 | -688 | 514 |
| PIKFYVE | 1048 | -2382 |
| PIP4K2A | -707 | 1772 |
| PIP4K2B | -2535 | -6347 |
| PIP4K2C | -4309 | -5573 |
| PIP5K1A | 2460 | -348 |
| PIP5K1C | 1151 | -5383 |
| PISD | 4093 | -4659 |
| PITPNB | -2252 | -4909 |
| PITPNM1 | 2289 | 873 |
| PITPNM2 | -1464 | 2520 |
| PITPNM3 | -1020 | 1888 |
| PLA2G12A | 2244 | -5029 |
| PLA2G15 | 4005 | -3722 |
| PLA2G4C | -859 | -4912 |
| PLA2G6 | -4758 | -3132 |
| PLB1 | 4405 | -5279 |
| PLD1 | 4321 | -6058 |
| PLD3 | 3177 | 1541 |
| PLD6 | -1150 | 2227 |
| PLEKHA2 | -419 | -4384 |
| PLEKHA3 | -1543 | -6547 |
| PLEKHA6 | -528 | -2325 |
| PLEKHA8 | -923 | -1764 |
| PLIN2 | 3718 | -96 |
| PLIN3 | 4385 | -3203 |
| PMVK | 1104 | 1829 |
| PNPLA2 | 4111 | -5698 |
| PNPLA6 | 2889 | -3173 |
| PNPLA7 | -2176 | -1431 |
| PNPLA8 | 3379 | -3836 |
| PON2 | -1901 | -4741 |
| PPARD | -1990 | 660 |
| PPARGC1B | -1534 | 1840 |
| PPM1L | -1031 | -4324 |
| PPP1CA | 1435 | 550 |
| PPP1CB | 3004 | 1839 |
| PPP1CC | 2581 | -754 |
| PPT1 | 4119 | -4371 |
| PPT2 | -4288 | -5624 |
| PRKAB2 | -2709 | -1428 |
| PRKACA | 4378 | -6032 |
| PRKACB | -4656 | 455 |
| PRKAG2 | 636 | -5033 |
| PRKD2 | -3006 | 229 |
| PSAP | 3061 | -4192 |
| PTDSS2 | 2331 | -1185 |
| PTEN | 3844 | -1100 |
| PTGES2 | -2198 | -1462 |
| PTGES3 | 1450 | -1810 |
| PTGR1 | 4217 | -6711 |
| PTGR2 | 385 | -3930 |
| PTPMT1 | 693 | 414 |
| PTPN13 | -3534 | -6489 |
| RAB14 | 3027 | 1334 |
| RAB4A | 3532 | -5479 |
| RAB5A | 3035 | -1686 |
| RAN | -2142 | 1257 |
| RGL1 | 3340 | 1731 |
| RORA | -4672 | 2287 |
| RUFY1 | 2621 | -4178 |
| SACM1L | -3188 | -1578 |
| SAMD8 | 3315 | -5347 |
| SAR1B | 2676 | 489 |
| SBF1 | -3835 | 882 |
| SC5D | -1097 | -6658 |
| SCAP | -1253 | -3851 |
| SCD | 1416 | -6126 |
| SCP2 | 1625 | -5793 |
| SEC23A | 3162 | -5141 |
| SEC24A | 3350 | 61 |
| SEC24B | 1233 | -5505 |
| SEC24C | -768 | 805 |
| SEC24D | 3637 | -3966 |
| SGMS1 | 4025 | -1653 |
| SGPL1 | 1110 | -2339 |
| SGPP1 | -4810 | -5414 |
| SIN3A | -3818 | -4151 |
| SIN3B | -1256 | 570 |
| SLC22A5 | 2925 | -5659 |
| SLC25A1 | 1857 | -910 |
| SLC25A17 | -3849 | -4326 |
| SLC25A20 | 1381 | 2245 |
| SLC27A1 | 3744 | -3528 |
| SLC27A2 | -1137 | -6055 |
| SLC27A3 | -258 | -1585 |
| SLC27A5 | -1076 | -3060 |
| SLC44A1 | 3877 | 2368 |
| SLC44A2 | 861 | 2003 |
| SMPD1 | 355 | -28 |
| SMPD2 | 793 | -918 |
| SMPD3 | -4824 | 2463 |
| SP1 | 3686 | -3141 |
| SPHK2 | 914 | -2294 |
| SPTLC1 | 3914 | -5493 |
| SPTLC2 | 3893 | 743 |
| SPTLC3 | 581 | 1742 |
| SPTSSA | 1715 | -5079 |
| SQLE | 1494 | -5831 |
| SRD5A1 | 3535 | 2146 |
| SRD5A3 | 1390 | 442 |
| SREBF1 | 2701 | -4015 |
| SREBF2 | 2792 | -1852 |
| STARD10 | 1786 | -337 |
| STARD3 | 1116 | -5163 |
| STARD3NL | 3182 | -4610 |
| STARD4 | -1221 | -2360 |
| STARD5 | -883 | -5368 |
| STARD7 | 1146 | -1506 |
| SUMF1 | 4144 | -5376 |
| SUMF2 | -4706 | -3692 |
| SYNJ1 | 2565 | 1501 |
| SYNJ2 | -2867 | -6043 |
| TBL1XR1 | 1669 | 962 |
| TBXAS1 | 4073 | -6709 |
| TECR | -3264 | -274 |
| THEM4 | -4130 | -6129 |
| TIAM2 | -4087 | -1035 |
| TM7SF2 | -2418 | -1255 |
| TNFAIP8 | -152 | 1226 |
| TNFAIP8L1 | -3518 | -4062 |
| TNFAIP8L2 | 2226 | -249 |
| TRIB3 | -1802 | 1669 |
| TSPO | 4344 | -6553 |
| TXNRD1 | 3685 | -4647 |
| UBE2I | -245 | 233 |
| UGCG | 2541 | 1914 |
| VAC14 | -38 | -2381 |
| VAPA | 4169 | -5592 |
| VAPB | 687 | -6771 |
| VDR | 3768 | -3651 |
Toll-like Receptor Cascades
| metric | value |
|---|---|
| setSize | 108 |
| pMANOVA | 7.51e-07 |
| p.adjustMANOVA | 1.13e-06 |
| s.dist | 0.295 |
| s.RNA | 0.295 |
| s.meth | 0.00249 |
| p.RNA | 1.23e-07 |
| p.meth | 0.964 |
| Gene | RNA | meth |
|---|---|---|
| TLR5 | 4260 | 1823 |
| PPP2CB | 3381 | 1797 |
| MAPK1 | 3249 | 1865 |
| NOD2 | 3833 | 1528 |
| TAB2 | 2942 | 1892 |
| ITGB2 | 4114 | 1322 |
| CHUK | 3543 | 1343 |
| FOS | 2120 | 2149 |
| IKBKE | 1750 | 2086 |
| MAP3K8 | 2489 | 1442 |
| NFKBIA | 2851 | 1159 |
| MAPKAPK2 | 1428 | 2012 |
| DNM2 | 2448 | 738 |
| PPP2CA | 3707 | 300 |
| UBE2N | 607 | 1127 |
| UBA52 | 349 | 752 |
| JUN | 1286 | 69 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| APP | 4249 | -5300 |
| ATF1 | 2245 | -2565 |
| BIRC2 | 1737 | -1862 |
| BIRC3 | -4159 | -2320 |
| BTRC | -1493 | -2427 |
| CASP8 | -4285 | 387 |
| CHUK | 3543 | 1343 |
| CNPY3 | 3416 | -3161 |
| CREB1 | -430 | -672 |
| CTSB | 4350 | -4209 |
| CTSL | 1504 | -6671 |
| CTSS | 3785 | -2958 |
| CTSV | -910 | -5834 |
| CUL1 | -4281 | -5146 |
| DNM1 | 1225 | -5619 |
| DNM2 | 2448 | 738 |
| DUSP3 | 4305 | -1798 |
| DUSP4 | -1957 | -3176 |
| DUSP6 | 1570 | -6763 |
| DUSP7 | -960 | -1322 |
| ECSIT | 1839 | -4938 |
| EEA1 | 1708 | -711 |
| FADD | 2211 | -6328 |
| FBXW11 | 2510 | -6747 |
| FOS | 2120 | 2149 |
| GSDMD | 614 | -3378 |
| HMGB1 | -86 | -1263 |
| HSP90B1 | 647 | -1371 |
| IKBKB | -1640 | -3894 |
| IKBKE | 1750 | 2086 |
| IRAK2 | -3327 | -1457 |
| IRAK3 | 4208 | -6295 |
| IRF3 | -2870 | 542 |
| IRF7 | -2922 | 1622 |
| ITGB2 | 4114 | 1322 |
| JUN | 1286 | 69 |
| LGMN | -1401 | 313 |
| MAP2K1 | 4183 | -698 |
| MAP2K3 | 4006 | -2657 |
| MAP2K4 | 2891 | -5363 |
| MAP2K6 | 4082 | -1130 |
| MAP2K7 | 514 | -3915 |
| MAP3K1 | 1942 | -176 |
| MAP3K7 | 761 | -2089 |
| MAP3K8 | 2489 | 1442 |
| MAPK1 | 3249 | 1865 |
| MAPK14 | 4207 | -3529 |
| MAPK3 | 4121 | -2448 |
| MAPK7 | -412 | -1630 |
| MAPK8 | -3265 | 6 |
| MAPK9 | -2259 | 872 |
| MAPKAPK2 | 1428 | 2012 |
| MAPKAPK3 | 3794 | -4540 |
| MEF2A | 3571 | -2822 |
| MYD88 | 3649 | -1927 |
| NFKB2 | -367 | 388 |
| NFKBIA | 2851 | 1159 |
| NFKBIB | -48 | -3368 |
| NKIRAS1 | 116 | -3490 |
| NKIRAS2 | 4346 | -5039 |
| NOD1 | -4837 | -5170 |
| NOD2 | 3833 | 1528 |
| PELI1 | 2800 | -3839 |
| PELI2 | 3750 | -2561 |
| PELI3 | 3383 | -4323 |
| PIK3R4 | -1215 | -3425 |
| PLCG2 | 1884 | -2562 |
| PPP2CA | 3707 | 300 |
| PPP2CB | 3381 | 1797 |
| PPP2R1B | -84 | -2554 |
| PPP2R5D | 771 | -4349 |
| PTPN11 | 2038 | -2302 |
| PTPN4 | -4818 | -3156 |
| RBSN | -1363 | -2813 |
| RELA | -542 | 2085 |
| RIPK3 | 1497 | -370 |
| RPS27A | -2201 | -2138 |
| RPS6KA1 | 3372 | -6629 |
| RPS6KA2 | 1006 | -1784 |
| RPS6KA5 | -4445 | -514 |
| SARM1 | -4766 | -5412 |
| SIGIRR | -3958 | 290 |
| SKP1 | 1536 | -2290 |
| SOCS1 | 1375 | -2999 |
| TAB2 | 2942 | 1892 |
| TANK | 3251 | -1331 |
| TBK1 | 1067 | -4616 |
| TICAM1 | 2569 | -2136 |
| TIRAP | 2210 | -5182 |
| TLR1 | 4106 | -6127 |
| TLR2 | 4206 | -6586 |
| TLR3 | -4406 | -5820 |
| TLR5 | 4260 | 1823 |
| TLR6 | 4058 | -802 |
| TLR9 | -1850 | 2292 |
| TNIP2 | 2166 | -5726 |
| TRAF3 | -1701 | 2379 |
| TRAF6 | -80 | -6118 |
| UBA52 | 349 | 752 |
| UBB | 2759 | -1321 |
| UBC | 1618 | -2568 |
| UBE2D1 | 4255 | -1581 |
| UBE2D2 | 1717 | -3799 |
| UBE2D3 | 3944 | -373 |
| UBE2N | 607 | 1127 |
| UBE2V1 | 2209 | -1021 |
| UNC93B1 | 1479 | -4358 |
| VRK3 | 396 | -1398 |
Peptide chain elongation
| metric | value |
|---|---|
| setSize | 67 |
| pMANOVA | 9.52e-07 |
| p.adjustMANOVA | 1.3e-06 |
| s.dist | 0.387 |
| s.RNA | -0.245 |
| s.meth | 0.3 |
| p.RNA | 0.000531 |
| p.meth | 2.26e-05 |
| Gene | RNA | meth |
|---|---|---|
| RPL3 | -2885 | 2313 |
| RPL23A | -3334 | 1843 |
| RPS11 | -2332 | 2115 |
| RPL13A | -2727 | 1802 |
| RPL32 | -2103 | 1928 |
| RPS2 | -1344 | 2392 |
| RPL35 | -2671 | 952 |
| RPL4 | -1064 | 2321 |
| RPS10 | -1780 | 1246 |
| RPS15 | -1095 | 1808 |
| RPS15A | -1762 | 1086 |
| RPL17 | -1654 | 1099 |
| RPS3A | -1419 | 1275 |
| RPS16 | -1410 | 1043 |
| RPLP2 | -2265 | 579 |
| RPS8 | -627 | 1886 |
| EEF1A1 | -1549 | 720 |
| RPS28 | -1426 | 525 |
| RPS25 | -1980 | 254 |
| RPL6 | -999 | 474 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EEF1A1 | -1549 | 720 |
| EEF2 | 90 | 2127 |
| FAU | -124 | -3862 |
| RPL10A | -2096 | -648 |
| RPL11 | -1944 | -2771 |
| RPL13 | -1024 | -191 |
| RPL13A | -2727 | 1802 |
| RPL14 | -2104 | -100 |
| RPL15 | -313 | -4694 |
| RPL17 | -1654 | 1099 |
| RPL18 | -1546 | -2031 |
| RPL18A | -1876 | -4966 |
| RPL22 | -1434 | -3996 |
| RPL23 | -990 | -566 |
| RPL23A | -3334 | 1843 |
| RPL26 | -2060 | -1489 |
| RPL26L1 | 3079 | -2860 |
| RPL27A | -1942 | -55 |
| RPL28 | -456 | -3478 |
| RPL29 | -1075 | 305 |
| RPL3 | -2885 | 2313 |
| RPL31 | -1362 | -2278 |
| RPL32 | -2103 | 1928 |
| RPL34 | -2147 | -3159 |
| RPL35 | -2671 | 952 |
| RPL36 | -1614 | 4 |
| RPL36AL | 9 | 1901 |
| RPL37 | -1982 | -126 |
| RPL37A | -1178 | 211 |
| RPL38 | -1800 | -818 |
| RPL39L | -2993 | -329 |
| RPL4 | -1064 | 2321 |
| RPL41 | -2172 | -229 |
| RPL6 | -999 | 474 |
| RPL7 | -589 | -6019 |
| RPL8 | -373 | -5267 |
| RPL9 | -566 | 741 |
| RPLP0 | -320 | -185 |
| RPLP1 | 3 | -4053 |
| RPLP2 | -2265 | 579 |
| RPS10 | -1780 | 1246 |
| RPS11 | -2332 | 2115 |
| RPS12 | -1841 | -379 |
| RPS15 | -1095 | 1808 |
| RPS15A | -1762 | 1086 |
| RPS16 | -1410 | 1043 |
| RPS18 | -2520 | -3281 |
| RPS19 | -2212 | -4563 |
| RPS2 | -1344 | 2392 |
| RPS20 | -3028 | -1962 |
| RPS23 | -1958 | -1981 |
| RPS24 | -87 | -2012 |
| RPS25 | -1980 | 254 |
| RPS26 | -446 | -3094 |
| RPS27A | -2201 | -2138 |
| RPS27L | 649 | -2218 |
| RPS28 | -1426 | 525 |
| RPS29 | -2606 | -159 |
| RPS3 | -1822 | -632 |
| RPS3A | -1419 | 1275 |
| RPS5 | -1744 | -1026 |
| RPS6 | -1906 | -1785 |
| RPS7 | -1509 | -2594 |
| RPS8 | -627 | 1886 |
| RPS9 | 2097 | 139 |
| RPSA | -1968 | -1486 |
| UBA52 | 349 | 752 |
Eukaryotic Translation Elongation
| metric | value |
|---|---|
| setSize | 70 |
| pMANOVA | 1.15e-06 |
| p.adjustMANOVA | 1.43e-06 |
| s.dist | 0.377 |
| s.RNA | -0.239 |
| s.meth | 0.291 |
| p.RNA | 0.00057 |
| p.meth | 2.6e-05 |
| Gene | RNA | meth |
|---|---|---|
| RPL3 | -2885 | 2313 |
| RPL23A | -3334 | 1843 |
| RPS11 | -2332 | 2115 |
| RPL13A | -2727 | 1802 |
| RPL32 | -2103 | 1928 |
| RPS2 | -1344 | 2392 |
| RPL35 | -2671 | 952 |
| RPL4 | -1064 | 2321 |
| RPS10 | -1780 | 1246 |
| EEF1B2 | -1271 | 1717 |
| RPS15 | -1095 | 1808 |
| RPS15A | -1762 | 1086 |
| RPL17 | -1654 | 1099 |
| RPS3A | -1419 | 1275 |
| RPS16 | -1410 | 1043 |
| RPLP2 | -2265 | 579 |
| RPS8 | -627 | 1886 |
| EEF1A1 | -1549 | 720 |
| RPS28 | -1426 | 525 |
| RPS25 | -1980 | 254 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EEF1A1 | -1549 | 720 |
| EEF1B2 | -1271 | 1717 |
| EEF1D | -268 | -885 |
| EEF1G | -431 | -5880 |
| EEF2 | 90 | 2127 |
| FAU | -124 | -3862 |
| RPL10A | -2096 | -648 |
| RPL11 | -1944 | -2771 |
| RPL13 | -1024 | -191 |
| RPL13A | -2727 | 1802 |
| RPL14 | -2104 | -100 |
| RPL15 | -313 | -4694 |
| RPL17 | -1654 | 1099 |
| RPL18 | -1546 | -2031 |
| RPL18A | -1876 | -4966 |
| RPL22 | -1434 | -3996 |
| RPL23 | -990 | -566 |
| RPL23A | -3334 | 1843 |
| RPL26 | -2060 | -1489 |
| RPL26L1 | 3079 | -2860 |
| RPL27A | -1942 | -55 |
| RPL28 | -456 | -3478 |
| RPL29 | -1075 | 305 |
| RPL3 | -2885 | 2313 |
| RPL31 | -1362 | -2278 |
| RPL32 | -2103 | 1928 |
| RPL34 | -2147 | -3159 |
| RPL35 | -2671 | 952 |
| RPL36 | -1614 | 4 |
| RPL36AL | 9 | 1901 |
| RPL37 | -1982 | -126 |
| RPL37A | -1178 | 211 |
| RPL38 | -1800 | -818 |
| RPL39L | -2993 | -329 |
| RPL4 | -1064 | 2321 |
| RPL41 | -2172 | -229 |
| RPL6 | -999 | 474 |
| RPL7 | -589 | -6019 |
| RPL8 | -373 | -5267 |
| RPL9 | -566 | 741 |
| RPLP0 | -320 | -185 |
| RPLP1 | 3 | -4053 |
| RPLP2 | -2265 | 579 |
| RPS10 | -1780 | 1246 |
| RPS11 | -2332 | 2115 |
| RPS12 | -1841 | -379 |
| RPS15 | -1095 | 1808 |
| RPS15A | -1762 | 1086 |
| RPS16 | -1410 | 1043 |
| RPS18 | -2520 | -3281 |
| RPS19 | -2212 | -4563 |
| RPS2 | -1344 | 2392 |
| RPS20 | -3028 | -1962 |
| RPS23 | -1958 | -1981 |
| RPS24 | -87 | -2012 |
| RPS25 | -1980 | 254 |
| RPS26 | -446 | -3094 |
| RPS27A | -2201 | -2138 |
| RPS27L | 649 | -2218 |
| RPS28 | -1426 | 525 |
| RPS29 | -2606 | -159 |
| RPS3 | -1822 | -632 |
| RPS3A | -1419 | 1275 |
| RPS5 | -1744 | -1026 |
| RPS6 | -1906 | -1785 |
| RPS7 | -1509 | -2594 |
| RPS8 | -627 | 1886 |
| RPS9 | 2097 | 139 |
| RPSA | -1968 | -1486 |
| UBA52 | 349 | 752 |
Toll Like Receptor 2 (TLR2) Cascade
| metric | value |
|---|---|
| setSize | 71 |
| pMANOVA | 1.34e-06 |
| p.adjustMANOVA | 1.54e-06 |
| s.dist | 0.357 |
| s.RNA | 0.357 |
| s.meth | -0.00759 |
| p.RNA | 2.09e-07 |
| p.meth | 0.912 |
| Gene | RNA | meth |
|---|---|---|
| TLR2 | 4206 | -6586 |
| IRAK3 | 4208 | -6295 |
| TLR1 | 4106 | -6127 |
| APP | 4249 | -5300 |
| RPS6KA1 | 3372 | -6629 |
| NKIRAS2 | 4346 | -5039 |
| MAPKAPK3 | 3794 | -4540 |
| FBXW11 | 2510 | -6747 |
| MAP2K4 | 2891 | -5363 |
| MAPK14 | 4207 | -3529 |
| PELI3 | 3383 | -4323 |
| TNIP2 | 2166 | -5726 |
| TIRAP | 2210 | -5182 |
| PELI1 | 2800 | -3839 |
| MAP2K3 | 4006 | -2657 |
| DUSP6 | 1570 | -6763 |
| MAPK3 | 4121 | -2448 |
| MEF2A | 3571 | -2822 |
| PELI2 | 3750 | -2561 |
| ECSIT | 1839 | -4938 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| APP | 4249 | -5300 |
| ATF1 | 2245 | -2565 |
| BTRC | -1493 | -2427 |
| CHUK | 3543 | 1343 |
| CREB1 | -430 | -672 |
| CUL1 | -4281 | -5146 |
| DUSP3 | 4305 | -1798 |
| DUSP4 | -1957 | -3176 |
| DUSP6 | 1570 | -6763 |
| DUSP7 | -960 | -1322 |
| ECSIT | 1839 | -4938 |
| FBXW11 | 2510 | -6747 |
| FOS | 2120 | 2149 |
| HMGB1 | -86 | -1263 |
| IKBKB | -1640 | -3894 |
| IRAK2 | -3327 | -1457 |
| IRAK3 | 4208 | -6295 |
| JUN | 1286 | 69 |
| MAP2K1 | 4183 | -698 |
| MAP2K3 | 4006 | -2657 |
| MAP2K4 | 2891 | -5363 |
| MAP2K6 | 4082 | -1130 |
| MAP2K7 | 514 | -3915 |
| MAP3K1 | 1942 | -176 |
| MAP3K7 | 761 | -2089 |
| MAP3K8 | 2489 | 1442 |
| MAPK1 | 3249 | 1865 |
| MAPK14 | 4207 | -3529 |
| MAPK3 | 4121 | -2448 |
| MAPK7 | -412 | -1630 |
| MAPK8 | -3265 | 6 |
| MAPK9 | -2259 | 872 |
| MAPKAPK2 | 1428 | 2012 |
| MAPKAPK3 | 3794 | -4540 |
| MEF2A | 3571 | -2822 |
| MYD88 | 3649 | -1927 |
| NFKB2 | -367 | 388 |
| NFKBIA | 2851 | 1159 |
| NFKBIB | -48 | -3368 |
| NKIRAS1 | 116 | -3490 |
| NKIRAS2 | 4346 | -5039 |
| NOD1 | -4837 | -5170 |
| NOD2 | 3833 | 1528 |
| PELI1 | 2800 | -3839 |
| PELI2 | 3750 | -2561 |
| PELI3 | 3383 | -4323 |
| PPP2CA | 3707 | 300 |
| PPP2CB | 3381 | 1797 |
| PPP2R1B | -84 | -2554 |
| PPP2R5D | 771 | -4349 |
| RELA | -542 | 2085 |
| RPS27A | -2201 | -2138 |
| RPS6KA1 | 3372 | -6629 |
| RPS6KA2 | 1006 | -1784 |
| RPS6KA5 | -4445 | -514 |
| SIGIRR | -3958 | 290 |
| SKP1 | 1536 | -2290 |
| SOCS1 | 1375 | -2999 |
| TAB2 | 2942 | 1892 |
| TIRAP | 2210 | -5182 |
| TLR1 | 4106 | -6127 |
| TLR2 | 4206 | -6586 |
| TLR6 | 4058 | -802 |
| TNIP2 | 2166 | -5726 |
| TRAF6 | -80 | -6118 |
| UBA52 | 349 | 752 |
| UBB | 2759 | -1321 |
| UBC | 1618 | -2568 |
| UBE2N | 607 | 1127 |
| UBE2V1 | 2209 | -1021 |
| VRK3 | 396 | -1398 |
rRNA modification in the nucleus and cytosol
| metric | value |
|---|---|
| setSize | 47 |
| pMANOVA | 7e-05 |
| p.adjustMANOVA | 7.5e-05 |
| s.dist | 0.374 |
| s.RNA | -0.366 |
| s.meth | 0.0777 |
| p.RNA | 1.44e-05 |
| p.meth | 0.358 |
| Gene | RNA | meth |
|---|---|---|
| NOP14 | -4022 | 2384 |
| RRP9 | -3589 | 2034 |
| SNU13 | -2174 | 1961 |
| WDR75 | -3509 | 1028 |
| NOC4L | -1668 | 1990 |
| RPS2 | -1344 | 2392 |
| NOL6 | -4043 | 526 |
| TBL3 | -1027 | 994 |
| IMP3 | -3288 | 99 |
| PWP2 | -378 | 681 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| BMS1 | -4492 | -2552 |
| DCAF13 | -1698 | -2001 |
| DDX47 | -4257 | -3056 |
| DDX49 | 1815 | -4408 |
| DDX52 | 142 | -1954 |
| DHX37 | -2753 | -312 |
| FBL | -3651 | -2611 |
| FCF1 | 1633 | -2675 |
| GAR1 | -2203 | -4416 |
| HEATR1 | -3738 | -1985 |
| IMP3 | -3288 | 99 |
| IMP4 | -4084 | -2925 |
| KRR1 | -2907 | -6562 |
| MPHOSPH10 | -2537 | -57 |
| NHP2 | -1038 | -260 |
| NOC4L | -1668 | 1990 |
| NOL11 | -3807 | -2629 |
| NOL6 | -4043 | 526 |
| NOP10 | 3759 | -3526 |
| NOP14 | -4022 | 2384 |
| NOP2 | -3530 | -2438 |
| NOP56 | -4540 | -523 |
| NOP58 | -3529 | -2406 |
| PDCD11 | -4401 | -2174 |
| PNO1 | -2170 | -5495 |
| PWP2 | -378 | 681 |
| RCL1 | -244 | -1421 |
| RPS2 | -1344 | 2392 |
| RPS6 | -1906 | -1785 |
| RPS7 | -1509 | -2594 |
| RPS9 | 2097 | 139 |
| RRP7A | -846 | -2961 |
| RRP9 | -3589 | 2034 |
| SNU13 | -2174 | 1961 |
| TBL3 | -1027 | 994 |
| THUMPD1 | -3443 | -4292 |
| TRMT112 | 233 | -4666 |
| TSR3 | 1337 | 1167 |
| UTP15 | -3872 | -2796 |
| UTP18 | 1940 | -3819 |
| UTP20 | -3834 | -1372 |
| UTP3 | -874 | -3665 |
| UTP6 | -1347 | -1904 |
| WDR3 | -2064 | -5710 |
| WDR36 | -1177 | -2277 |
| WDR43 | -2494 | -4225 |
| WDR75 | -3509 | 1028 |
alpha-linolenic acid (ALA) metabolism
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.000274 |
| p.adjustMANOVA | 0.000274 |
| s.dist | 0.758 |
| s.RNA | 0.71 |
| s.meth | -0.266 |
| p.RNA | 0.000101 |
| p.meth | 0.145 |
| Gene | RNA | meth |
|---|---|---|
| HSD17B4 | 4069 | -5528 |
| ACOX1 | 4070 | -5075 |
| FADS1 | 3374 | -4312 |
| SCP2 | 1625 | -5793 |
| ACOT8 | 3578 | -2563 |
| ELOVL5 | 2406 | -3408 |
| ACSL1 | 4266 | -1604 |
| ELOVL1 | 3022 | -1168 |
| FADS2 | 458 | -5605 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| ACAA1 | 3734 | 1410 |
| ACOT8 | 3578 | -2563 |
| ACOX1 | 4070 | -5075 |
| ACSL1 | 4266 | -1604 |
| ELOVL1 | 3022 | -1168 |
| ELOVL5 | 2406 | -3408 |
| FADS1 | 3374 | -4312 |
| FADS2 | 458 | -5605 |
| HSD17B4 | 4069 | -5528 |
| SCP2 | 1625 | -5793 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.1.0 (2021-05-18)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] stats graphics grDevices utils datasets methods base
##
## other attached packages:
## [1] pkgload_1.2.1 GGally_2.1.2 ggplot2_3.3.5 reshape2_1.4.4
## [5] beeswarm_0.4.0 gtools_3.9.2 tibble_3.1.3 dplyr_1.0.7
## [9] echarts4r_0.4.1 kableExtra_1.3.4 mitch_1.4.0 gplots_3.1.1
##
## loaded via a namespace (and not attached):
## [1] httr_1.4.2 sass_0.4.0 jsonlite_1.7.2 viridisLite_0.4.0
## [5] bslib_0.2.5.1 shiny_1.6.0 assertthat_0.2.1 highr_0.9
## [9] progress_1.2.2 yaml_2.2.1 pillar_1.6.1 glue_1.4.2
## [13] digest_0.6.27 RColorBrewer_1.1-2 promises_1.2.0.1 rvest_1.0.0
## [17] colorspace_2.0-2 htmltools_0.5.1.1 httpuv_1.6.1 plyr_1.8.6
## [21] pkgconfig_2.0.3 purrr_0.3.4 xtable_1.8-4 scales_1.1.1
## [25] webshot_0.5.2 svglite_2.0.0 later_1.2.0 generics_0.1.0
## [29] farver_2.1.0 ellipsis_0.3.2 withr_2.4.2 magrittr_2.0.1
## [33] crayon_1.4.1 mime_0.11 evaluate_0.14 fansi_0.5.0
## [37] MASS_7.3-54 xml2_1.3.2 prettyunits_1.1.1 tools_4.1.0
## [41] hms_1.1.0 lifecycle_1.0.0 stringr_1.4.0 munsell_0.5.0
## [45] compiler_4.1.0 jquerylib_0.1.4 caTools_1.18.2 systemfonts_1.0.2
## [49] rlang_0.4.11 grid_4.1.0 rstudioapi_0.13 htmlwidgets_1.5.3
## [53] bitops_1.0-7 labeling_0.4.2 rmarkdown_2.9 gtable_0.3.0
## [57] DBI_1.1.1 reshape_0.8.8 R6_2.5.0 gridExtra_2.3
## [61] knitr_1.33 fastmap_1.1.0 utf8_1.2.2 rprojroot_2.0.2
## [65] KernSmooth_2.23-20 desc_1.3.0 stringi_1.7.3 parallel_4.1.0
## [69] Rcpp_1.0.7 vctrs_0.3.8 tidyselect_1.1.1 xfun_0.24END of report