date generated: 2021-04-27

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##               RNA        meth
## A1BG  -0.30654761 0.100632259
## AAAS  -0.72511657 0.230035602
## AACS   0.09916863 0.682403328
## AAGAB  0.67982671 0.001540913
## AAK1  -0.73201617 0.360863030
## AAMDC -0.04498728 0.383673218

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 9286
duplicated_genes_present 0
num_profile_genes_in_sets 5591
num_profile_genes_not_in_sets 3695
profile_pearson_correl -0.10019
profile_spearman_correl -0.07239

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2484
num_genesets_excluded 1323
num_genesets_included 1161

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 424

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.RNA s.meth p.RNA p.meth
Neutrophil degranulation 305 1.84e-43 2.14e-40 0.473 0.468 -0.063800 1.56e-44 5.79e-02
Innate Immune System 616 3.63e-39 2.11e-36 0.318 0.318 0.000995 3.60e-40 9.67e-01
rRNA processing 159 2.24e-36 8.68e-34 0.596 -0.584 0.123000 6.59e-37 7.86e-03
rRNA processing in the nucleus and cytosol 154 1.52e-35 4.42e-33 0.600 -0.585 0.133000 6.49e-36 4.59e-03
Major pathway of rRNA processing in the nucleolus and cytosol 147 2.33e-35 5.40e-33 0.612 -0.597 0.135000 9.38e-36 5.05e-03
Immune System 1142 8.47e-34 1.64e-31 0.221 0.218 0.034900 2.87e-33 5.58e-02
Eukaryotic Translation Elongation 70 2.39e-26 3.96e-24 0.763 -0.734 0.205000 2.06e-26 3.05e-03
Formation of a pool of free 40S subunits 76 8.93e-26 1.30e-23 0.723 -0.700 0.182000 4.84e-26 6.22e-03
Peptide chain elongation 67 3.94e-25 5.08e-23 0.761 -0.732 0.208000 3.43e-25 3.29e-03
Signal Transduction 1290 5.27e-25 6.12e-23 0.179 0.171 0.052800 5.57e-23 2.30e-03
Metabolism of RNA 535 5.95e-25 6.28e-23 0.277 -0.259 0.096400 4.75e-24 1.77e-04
Translation 234 6.93e-25 6.70e-23 0.404 -0.402 0.047200 5.81e-26 2.17e-01
L13a-mediated translational silencing of Ceruloplasmin expression 85 1.43e-23 1.25e-21 0.655 -0.627 0.190000 1.68e-23 2.47e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 86 1.51e-23 1.25e-21 0.651 -0.621 0.195000 2.26e-23 1.78e-03
Selenocysteine synthesis 68 1.64e-23 1.27e-21 0.729 -0.705 0.184000 7.89e-24 8.84e-03
Viral mRNA Translation 67 2.23e-23 1.62e-21 0.735 -0.701 0.220000 3.21e-23 1.90e-03
Influenza Viral RNA Transcription and Replication 110 4.42e-23 3.02e-21 0.574 -0.532 0.215000 6.25e-22 1.04e-04
Eukaryotic Translation Termination 70 1.34e-22 8.61e-21 0.703 -0.685 0.158000 3.69e-23 2.25e-02
Cap-dependent Translation Initiation 93 2.31e-22 1.34e-20 0.611 -0.580 0.193000 4.63e-22 1.33e-03
Eukaryotic Translation Initiation 93 2.31e-22 1.34e-20 0.611 -0.580 0.193000 4.63e-22 1.33e-03
Membrane Trafficking 436 7.78e-22 4.30e-20 0.278 0.278 -0.002330 7.61e-23 9.34e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 72 1.02e-21 5.38e-20 0.683 -0.651 0.206000 1.30e-21 2.59e-03
Vesicle-mediated transport 442 1.60e-21 8.09e-20 0.274 0.274 0.004040 1.87e-22 8.86e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 76 1.05e-20 5.08e-19 0.647 -0.625 0.167000 4.83e-21 1.20e-02
Selenoamino acid metabolism 76 3.41e-20 1.58e-18 0.638 -0.616 0.166000 1.57e-20 1.25e-02
Influenza Infection 128 8.20e-20 3.66e-18 0.493 -0.448 0.207000 2.54e-18 5.65e-05
SRP-dependent cotranslational protein targeting to membrane 85 6.57e-19 2.83e-17 0.587 -0.550 0.205000 1.92e-18 1.13e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 86 1.64e-18 6.56e-17 0.578 -0.537 0.215000 8.41e-18 5.80e-04
Nonsense-Mediated Decay (NMD) 86 1.64e-18 6.56e-17 0.578 -0.537 0.215000 8.41e-18 5.80e-04
Signaling by Receptor Tyrosine Kinases 284 1.18e-14 4.56e-13 0.275 0.273 0.032900 3.75e-15 3.44e-01
Metabolism of lipids 427 3.45e-12 1.29e-10 0.210 0.206 -0.037200 5.07e-13 1.94e-01
Hemostasis 303 9.59e-12 3.48e-10 0.240 0.240 -0.012300 1.07e-12 7.15e-01
Regulation of expression of SLITs and ROBOs 122 1.75e-11 6.17e-10 0.381 -0.327 0.195000 4.74e-10 2.03e-04
Formation of the ternary complex, and subsequently, the 43S complex 40 2.01e-11 6.86e-10 0.652 -0.628 0.175000 6.24e-12 5.64e-02
Signaling by Interleukins 263 4.95e-11 1.64e-09 0.241 0.214 0.111000 3.13e-09 2.14e-03
Platelet activation, signaling and aggregation 133 5.16e-11 1.66e-09 0.341 0.334 0.067900 3.27e-11 1.78e-01
rRNA modification in the nucleus and cytosol 47 1.67e-10 5.23e-09 0.573 -0.560 0.123000 3.18e-11 1.44e-01
Gene expression (Transcription) 1003 2.18e-10 6.67e-09 0.133 -0.107 0.079400 3.21e-08 3.87e-05
Translation initiation complex formation 47 5.71e-10 1.70e-08 0.561 -0.534 0.172000 2.48e-10 4.15e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 48 1.05e-09 2.97e-08 0.548 -0.518 0.176000 5.29e-10 3.47e-02
Ribosomal scanning and start codon recognition 47 1.05e-09 2.97e-08 0.553 -0.524 0.178000 5.28e-10 3.49e-02
Diseases of signal transduction by growth factor receptors and second messengers 264 2.86e-09 7.91e-08 0.220 0.207 0.075900 9.51e-09 3.53e-02
Cytokine Signaling in Immune system 424 4.77e-09 1.26e-07 0.171 0.135 0.105000 2.48e-06 2.51e-04
tRNA processing 93 4.78e-09 1.26e-07 0.377 -0.368 0.082400 9.37e-10 1.71e-01
Signaling by WNT 174 7.65e-09 1.97e-07 0.260 0.173 0.194000 8.78e-05 1.14e-05
Signaling by NOTCH 129 9.60e-09 2.42e-07 0.300 0.241 0.178000 2.36e-06 5.18e-04
Leishmania infection 110 1.89e-08 4.66e-07 0.331 0.330 -0.020800 2.46e-09 7.07e-01
Cellular response to starvation 119 3.28e-08 7.93e-07 0.320 -0.293 0.129000 3.69e-08 1.51e-02
PIP3 activates AKT signaling 181 6.42e-08 1.52e-06 0.240 0.177 0.162000 4.49e-05 1.78e-04
Disease 929 6.98e-08 1.62e-06 0.110 0.085 0.070400 2.05e-05 4.22e-04


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.RNA s.meth p.RNA p.meth
Neutrophil degranulation 305 1.84e-43 2.14e-40 0.4730 0.468000 -0.063800 1.56e-44 5.79e-02
Innate Immune System 616 3.63e-39 2.11e-36 0.3180 0.318000 0.000995 3.60e-40 9.67e-01
rRNA processing 159 2.24e-36 8.68e-34 0.5960 -0.584000 0.123000 6.59e-37 7.86e-03
rRNA processing in the nucleus and cytosol 154 1.52e-35 4.42e-33 0.6000 -0.585000 0.133000 6.49e-36 4.59e-03
Major pathway of rRNA processing in the nucleolus and cytosol 147 2.33e-35 5.40e-33 0.6120 -0.597000 0.135000 9.38e-36 5.05e-03
Immune System 1142 8.47e-34 1.64e-31 0.2210 0.218000 0.034900 2.87e-33 5.58e-02
Eukaryotic Translation Elongation 70 2.39e-26 3.96e-24 0.7630 -0.734000 0.205000 2.06e-26 3.05e-03
Formation of a pool of free 40S subunits 76 8.93e-26 1.30e-23 0.7230 -0.700000 0.182000 4.84e-26 6.22e-03
Peptide chain elongation 67 3.94e-25 5.08e-23 0.7610 -0.732000 0.208000 3.43e-25 3.29e-03
Signal Transduction 1290 5.27e-25 6.12e-23 0.1790 0.171000 0.052800 5.57e-23 2.30e-03
Metabolism of RNA 535 5.95e-25 6.28e-23 0.2770 -0.259000 0.096400 4.75e-24 1.77e-04
Translation 234 6.93e-25 6.70e-23 0.4040 -0.402000 0.047200 5.81e-26 2.17e-01
L13a-mediated translational silencing of Ceruloplasmin expression 85 1.43e-23 1.25e-21 0.6550 -0.627000 0.190000 1.68e-23 2.47e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 86 1.51e-23 1.25e-21 0.6510 -0.621000 0.195000 2.26e-23 1.78e-03
Selenocysteine synthesis 68 1.64e-23 1.27e-21 0.7290 -0.705000 0.184000 7.89e-24 8.84e-03
Viral mRNA Translation 67 2.23e-23 1.62e-21 0.7350 -0.701000 0.220000 3.21e-23 1.90e-03
Influenza Viral RNA Transcription and Replication 110 4.42e-23 3.02e-21 0.5740 -0.532000 0.215000 6.25e-22 1.04e-04
Eukaryotic Translation Termination 70 1.34e-22 8.61e-21 0.7030 -0.685000 0.158000 3.69e-23 2.25e-02
Cap-dependent Translation Initiation 93 2.31e-22 1.34e-20 0.6110 -0.580000 0.193000 4.63e-22 1.33e-03
Eukaryotic Translation Initiation 93 2.31e-22 1.34e-20 0.6110 -0.580000 0.193000 4.63e-22 1.33e-03
Membrane Trafficking 436 7.78e-22 4.30e-20 0.2780 0.278000 -0.002330 7.61e-23 9.34e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 72 1.02e-21 5.38e-20 0.6830 -0.651000 0.206000 1.30e-21 2.59e-03
Vesicle-mediated transport 442 1.60e-21 8.09e-20 0.2740 0.274000 0.004040 1.87e-22 8.86e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 76 1.05e-20 5.08e-19 0.6470 -0.625000 0.167000 4.83e-21 1.20e-02
Selenoamino acid metabolism 76 3.41e-20 1.58e-18 0.6380 -0.616000 0.166000 1.57e-20 1.25e-02
Influenza Infection 128 8.20e-20 3.66e-18 0.4930 -0.448000 0.207000 2.54e-18 5.65e-05
SRP-dependent cotranslational protein targeting to membrane 85 6.57e-19 2.83e-17 0.5870 -0.550000 0.205000 1.92e-18 1.13e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 86 1.64e-18 6.56e-17 0.5780 -0.537000 0.215000 8.41e-18 5.80e-04
Nonsense-Mediated Decay (NMD) 86 1.64e-18 6.56e-17 0.5780 -0.537000 0.215000 8.41e-18 5.80e-04
Signaling by Receptor Tyrosine Kinases 284 1.18e-14 4.56e-13 0.2750 0.273000 0.032900 3.75e-15 3.44e-01
Metabolism of lipids 427 3.45e-12 1.29e-10 0.2100 0.206000 -0.037200 5.07e-13 1.94e-01
Hemostasis 303 9.59e-12 3.48e-10 0.2400 0.240000 -0.012300 1.07e-12 7.15e-01
Regulation of expression of SLITs and ROBOs 122 1.75e-11 6.17e-10 0.3810 -0.327000 0.195000 4.74e-10 2.03e-04
Formation of the ternary complex, and subsequently, the 43S complex 40 2.01e-11 6.86e-10 0.6520 -0.628000 0.175000 6.24e-12 5.64e-02
Signaling by Interleukins 263 4.95e-11 1.64e-09 0.2410 0.214000 0.111000 3.13e-09 2.14e-03
Platelet activation, signaling and aggregation 133 5.16e-11 1.66e-09 0.3410 0.334000 0.067900 3.27e-11 1.78e-01
rRNA modification in the nucleus and cytosol 47 1.67e-10 5.23e-09 0.5730 -0.560000 0.123000 3.18e-11 1.44e-01
Gene expression (Transcription) 1003 2.18e-10 6.67e-09 0.1330 -0.107000 0.079400 3.21e-08 3.87e-05
Translation initiation complex formation 47 5.71e-10 1.70e-08 0.5610 -0.534000 0.172000 2.48e-10 4.15e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 48 1.05e-09 2.97e-08 0.5480 -0.518000 0.176000 5.29e-10 3.47e-02
Ribosomal scanning and start codon recognition 47 1.05e-09 2.97e-08 0.5530 -0.524000 0.178000 5.28e-10 3.49e-02
Diseases of signal transduction by growth factor receptors and second messengers 264 2.86e-09 7.91e-08 0.2200 0.207000 0.075900 9.51e-09 3.53e-02
Cytokine Signaling in Immune system 424 4.77e-09 1.26e-07 0.1710 0.135000 0.105000 2.48e-06 2.51e-04
tRNA processing 93 4.78e-09 1.26e-07 0.3770 -0.368000 0.082400 9.37e-10 1.71e-01
Signaling by WNT 174 7.65e-09 1.97e-07 0.2600 0.173000 0.194000 8.78e-05 1.14e-05
Signaling by NOTCH 129 9.60e-09 2.42e-07 0.3000 0.241000 0.178000 2.36e-06 5.18e-04
Leishmania infection 110 1.89e-08 4.66e-07 0.3310 0.330000 -0.020800 2.46e-09 7.07e-01
Cellular response to starvation 119 3.28e-08 7.93e-07 0.3200 -0.293000 0.129000 3.69e-08 1.51e-02
PIP3 activates AKT signaling 181 6.42e-08 1.52e-06 0.2400 0.177000 0.162000 4.49e-05 1.78e-04
Disease 929 6.98e-08 1.62e-06 0.1100 0.085000 0.070400 2.05e-05 4.22e-04
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 434 7.30e-08 1.66e-06 0.1600 0.156000 0.035100 3.95e-08 2.16e-01
Post-translational protein modification 888 9.10e-08 2.03e-06 0.1130 0.108000 0.033800 1.09e-07 9.67e-02
Signaling by Rho GTPases 422 9.60e-08 2.10e-06 0.1600 0.156000 0.036400 5.47e-08 2.05e-01
EPH-Ephrin signaling 54 1.57e-07 3.38e-06 0.4380 0.438000 0.015600 2.62e-08 8.43e-01
Intracellular signaling by second messengers 206 1.77e-07 3.74e-06 0.2190 0.174000 0.132000 1.86e-05 1.16e-03
Clathrin-mediated endocytosis 90 1.99e-07 4.12e-06 0.3350 0.331000 0.051100 6.05e-08 4.04e-01
Signaling by NTRKs 90 2.09e-07 4.26e-06 0.3320 0.321000 0.086800 1.57e-07 1.56e-01
Regulation of actin dynamics for phagocytic cup formation 45 2.46e-07 4.92e-06 0.4740 0.474000 0.000281 3.75e-08 9.97e-01
Signaling by ROBO receptors 153 2.92e-07 5.76e-06 0.2670 -0.218000 0.153000 3.44e-06 1.16e-03
GPCR downstream signalling 183 3.08e-07 5.96e-06 0.2390 0.234000 -0.046300 5.54e-08 2.83e-01
Signaling by GPCR 199 3.39e-07 6.45e-06 0.2280 0.225000 -0.039200 5.63e-08 3.43e-01
Mitochondrial translation elongation 83 3.75e-07 7.03e-06 0.3400 -0.331000 -0.078200 2.04e-07 2.19e-01
ER to Golgi Anterograde Transport 105 4.58e-07 8.44e-06 0.3100 0.303000 -0.066800 9.08e-08 2.38e-01
Rab regulation of trafficking 89 8.62e-07 1.56e-05 0.3220 0.320000 0.029800 1.85e-07 6.28e-01
Generic Transcription Pathway 800 1.05e-06 1.88e-05 0.1160 -0.095500 0.065200 7.65e-06 2.27e-03
Mitochondrial translation initiation 83 1.08e-06 1.90e-05 0.3270 -0.315000 -0.086500 7.41e-07 1.74e-01
FCGR3A-mediated phagocytosis 43 1.15e-06 1.93e-05 0.4590 0.459000 0.010300 1.92e-07 9.07e-01
Leishmania phagocytosis 43 1.15e-06 1.93e-05 0.4590 0.459000 0.010300 1.92e-07 9.07e-01
Parasite infection 43 1.15e-06 1.93e-05 0.4590 0.459000 0.010300 1.92e-07 9.07e-01
Transport to the Golgi and subsequent modification 127 1.18e-06 1.95e-05 0.2730 0.267000 -0.054300 2.21e-07 2.92e-01
MHC class II antigen presentation 70 1.30e-06 2.12e-05 0.3620 0.360000 -0.034000 1.93e-07 6.24e-01
Transport of small molecules 342 1.34e-06 2.16e-05 0.1670 0.165000 -0.027000 2.23e-07 3.96e-01
Activation of the pre-replicative complex 28 1.39e-06 2.19e-05 0.5760 -0.556000 0.151000 3.51e-07 1.67e-01
Metabolism of amino acids and derivatives 218 1.42e-06 2.19e-05 0.2100 -0.196000 0.075700 7.42e-07 5.58e-02
Mitochondrial translation 88 1.42e-06 2.19e-05 0.3150 -0.305000 -0.076000 7.82e-07 2.19e-01
Asparagine N-linked glycosylation 222 1.46e-06 2.23e-05 0.2040 0.203000 -0.017800 2.18e-07 6.50e-01
RNA Polymerase II Transcription 892 1.53e-06 2.31e-05 0.1090 -0.084800 0.068100 3.01e-05 8.04e-04
Mitochondrial translation termination 82 1.72e-06 2.53e-05 0.3230 -0.314000 -0.078500 9.49e-07 2.20e-01
RHO GTPase cycle 281 1.72e-06 2.53e-05 0.1770 0.172000 0.039300 8.08e-07 2.61e-01
Fcgamma receptor (FCGR) dependent phagocytosis 63 1.88e-06 2.72e-05 0.3770 0.374000 -0.048000 2.94e-07 5.11e-01
Signaling by NTRK1 (TRKA) 82 2.37e-06 3.40e-05 0.3190 0.309000 0.080300 1.38e-06 2.10e-01
RAB GEFs exchange GTP for GDP on RABs 61 3.13e-06 4.43e-05 0.3770 0.372000 -0.059700 5.29e-07 4.21e-01
Beta-catenin independent WNT signaling 105 6.19e-06 8.65e-05 0.2670 0.169000 0.207000 2.84e-03 2.57e-04
Adaptive Immune System 475 6.71e-06 9.27e-05 0.1290 0.120000 0.048200 1.05e-05 7.65e-02
trans-Golgi Network Vesicle Budding 52 6.91e-06 9.43e-05 0.3960 0.387000 -0.083300 1.39e-06 3.00e-01
TCF dependent signaling in response to WNT 117 7.45e-06 1.01e-04 0.2520 0.133000 0.214000 1.32e-02 6.64e-05
Intra-Golgi and retrograde Golgi-to-ER traffic 155 9.00e-06 1.20e-04 0.2250 0.225000 -0.005520 1.47e-06 9.06e-01
COPI-mediated anterograde transport 68 9.18e-06 1.21e-04 0.3420 0.335000 -0.070300 1.83e-06 3.17e-01
Toll-like Receptor Cascades 108 1.11e-05 1.44e-04 0.2630 0.261000 0.037500 3.02e-06 5.02e-01
Degradation of the extracellular matrix 35 1.23e-05 1.58e-04 0.4610 0.460000 0.029300 2.45e-06 7.64e-01
Metabolism of non-coding RNA 47 1.38e-05 1.74e-04 0.4060 -0.392000 0.104000 3.42e-06 2.16e-01
snRNP Assembly 47 1.38e-05 1.74e-04 0.4060 -0.392000 0.104000 3.42e-06 2.16e-01
Gene Silencing by RNA 60 1.40e-05 1.74e-04 0.3660 -0.227000 0.286000 2.35e-03 1.29e-04
Infectious disease 530 1.43e-05 1.77e-04 0.1190 0.035200 0.114000 1.73e-01 1.03e-05
Activation of ATR in response to replication stress 34 1.56e-05 1.91e-04 0.4740 -0.456000 0.130000 4.19e-06 1.91e-01
DNA strand elongation 27 1.92e-05 2.31e-04 0.5240 -0.514000 0.102000 3.75e-06 3.61e-01
RHOC GTPase cycle 49 1.93e-05 2.31e-04 0.3740 0.336000 0.163000 4.80e-05 4.82e-02
RAC1 GTPase cycle 109 1.96e-05 2.33e-04 0.2610 0.258000 -0.036300 3.40e-06 5.14e-01
Golgi-to-ER retrograde transport 92 2.09e-05 2.45e-04 0.2800 0.280000 0.004470 3.76e-06 9.41e-01
CDC42 GTPase cycle 95 2.14e-05 2.46e-04 0.2740 0.274000 0.013200 4.15e-06 8.25e-01
Semaphorin interactions 39 2.14e-05 2.46e-04 0.4360 0.421000 -0.115000 5.49e-06 2.14e-01
RHO GTPases Activate WASPs and WAVEs 29 2.16e-05 2.46e-04 0.5010 0.497000 -0.065000 3.71e-06 5.45e-01
PTEN Regulation 114 2.42e-05 2.73e-04 0.2420 0.155000 0.185000 4.40e-03 6.54e-04
Toll Like Receptor 4 (TLR4) Cascade 93 2.67e-05 2.98e-04 0.2730 0.272000 0.028300 6.20e-06 6.38e-01
Chromosome Maintenance 74 2.79e-05 3.09e-04 0.3160 -0.294000 0.116000 1.31e-05 8.59e-02
Programmed Cell Death 153 4.82e-05 5.28e-04 0.2040 0.187000 0.081900 7.25e-05 8.20e-02
RHO GTPases Activate ROCKs 13 5.76e-05 6.25e-04 0.7060 0.706000 -0.000174 1.05e-05 9.99e-01
tRNA processing in the nucleus 55 5.99e-05 6.44e-04 0.3470 -0.343000 0.052600 1.11e-05 5.00e-01
Interleukin-1 family signaling 98 6.26e-05 6.67e-04 0.2500 0.219000 0.119000 1.82e-04 4.20e-02
Metabolism 1215 6.35e-05 6.70e-04 0.0788 0.077700 -0.013000 1.20e-05 4.66e-01
MAP2K and MAPK activation 25 7.19e-05 7.47e-04 0.5010 0.499000 0.038800 1.56e-05 7.38e-01
PPARA activates gene expression 79 7.24e-05 7.47e-04 0.2810 0.279000 0.036300 1.87e-05 5.78e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 7.33e-05 7.47e-04 0.7730 0.699000 0.332000 1.31e-04 6.94e-02
alpha-linolenic acid (ALA) metabolism 10 7.33e-05 7.47e-04 0.7730 0.699000 0.332000 1.31e-04 6.94e-02
EPHB-mediated forward signaling 24 7.40e-05 7.47e-04 0.5160 0.514000 -0.034800 1.29e-05 7.68e-01
SARS-CoV Infections 115 8.66e-05 8.66e-04 0.2260 0.147000 0.172000 6.83e-03 1.53e-03
Phospholipid metabolism 129 8.88e-05 8.82e-04 0.2240 0.217000 -0.055400 2.15e-05 2.79e-01
Response to elevated platelet cytosolic Ca2+ 53 1.03e-04 9.98e-04 0.3420 0.341000 -0.024700 1.82e-05 7.56e-01
Signal transduction by L1 11 1.03e-04 9.98e-04 0.7270 0.684000 0.248000 8.60e-05 1.54e-01
RHOA GTPase cycle 91 1.03e-04 9.98e-04 0.2570 0.253000 0.044700 3.23e-05 4.62e-01
MAPK family signaling cascades 184 1.07e-04 1.03e-03 0.1770 0.138000 0.111000 1.35e-03 9.62e-03
RHO GTPases activate PKNs 25 1.20e-04 1.14e-03 0.4810 0.462000 0.132000 6.37e-05 2.54e-01
Cargo recognition for clathrin-mediated endocytosis 65 1.23e-04 1.16e-03 0.3020 0.300000 0.032300 2.96e-05 6.53e-01
L1CAM interactions 40 1.29e-04 1.20e-03 0.3890 0.387000 -0.033500 2.31e-05 7.14e-01
Ion channel transport 80 1.30e-04 1.21e-03 0.2830 0.244000 -0.143000 1.72e-04 2.72e-02
Golgi Associated Vesicle Biogenesis 39 1.35e-04 1.24e-03 0.4010 0.369000 -0.156000 6.79e-05 9.23e-02
Pre-NOTCH Processing in Golgi 15 1.47e-04 1.34e-03 0.6030 0.430000 0.423000 3.94e-03 4.54e-03
RAC2 GTPase cycle 58 1.50e-04 1.36e-03 0.3230 0.316000 -0.066400 3.23e-05 3.83e-01
Regulation of lipid metabolism by PPARalpha 81 1.55e-04 1.40e-03 0.2670 0.265000 0.030400 3.84e-05 6.38e-01
Signaling by high-kinase activity BRAF mutants 22 1.72e-04 1.53e-03 0.5070 0.501000 0.071700 4.70e-05 5.61e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 46 1.72e-04 1.53e-03 0.3660 0.310000 -0.195000 2.74e-04 2.26e-02
Metabolism of steroids 81 1.83e-04 1.61e-03 0.2720 0.261000 -0.078000 5.23e-05 2.26e-01
Regulation of PTEN stability and activity 56 1.90e-04 1.66e-03 0.3080 0.216000 0.220000 5.29e-03 4.39e-03
Signaling by RAF1 mutants 25 1.96e-04 1.70e-03 0.4690 0.457000 0.106000 7.70e-05 3.61e-01
Rev-mediated nuclear export of HIV RNA 33 2.03e-04 1.73e-03 0.4270 -0.374000 0.206000 1.99e-04 4.12e-02
Telomere C-strand (Lagging Strand) Synthesis 29 2.03e-04 1.73e-03 0.4530 -0.421000 0.167000 8.84e-05 1.19e-01
G alpha (i) signalling events 87 2.09e-04 1.77e-03 0.2610 0.248000 -0.080000 6.53e-05 1.98e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 71 2.19e-04 1.80e-03 0.2850 0.281000 -0.046500 4.36e-05 4.99e-01
Toll Like Receptor 2 (TLR2) Cascade 71 2.19e-04 1.80e-03 0.2850 0.281000 -0.046500 4.36e-05 4.99e-01
Toll Like Receptor TLR1:TLR2 Cascade 71 2.19e-04 1.80e-03 0.2850 0.281000 -0.046500 4.36e-05 4.99e-01
Toll Like Receptor TLR6:TLR2 Cascade 71 2.19e-04 1.80e-03 0.2850 0.281000 -0.046500 4.36e-05 4.99e-01
Interactions of Vpr with host cellular proteins 33 2.42e-04 1.98e-03 0.4220 -0.376000 0.192000 1.89e-04 5.59e-02
Platelet degranulation 49 2.46e-04 2.00e-03 0.3390 0.337000 -0.040400 4.66e-05 6.25e-01
COPI-independent Golgi-to-ER retrograde traffic 28 2.57e-04 2.07e-03 0.4420 0.442000 0.015100 5.28e-05 8.90e-01
PCP/CE pathway 71 2.64e-04 2.12e-03 0.2690 0.164000 0.213000 1.69e-02 1.94e-03
Extension of Telomeres 44 2.74e-04 2.17e-03 0.3620 -0.333000 0.142000 1.35e-04 1.04e-01
G-protein beta:gamma signalling 20 2.74e-04 2.17e-03 0.5120 0.491000 0.145000 1.45e-04 2.62e-01
Pre-NOTCH Expression and Processing 41 2.85e-04 2.23e-03 0.3520 0.293000 0.195000 1.17e-03 3.06e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 20 2.86e-04 2.23e-03 0.5350 -0.492000 0.210000 1.41e-04 1.04e-01
S Phase 138 2.95e-04 2.29e-03 0.2070 -0.153000 0.138000 1.95e-03 5.16e-03
Integration of energy metabolism 58 3.01e-04 2.31e-03 0.3120 0.296000 -0.101000 1.02e-04 1.83e-01
RHOB GTPase cycle 44 3.06e-04 2.34e-03 0.3430 0.330000 0.094800 1.54e-04 2.78e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 30 3.32e-04 2.52e-03 0.4100 0.372000 0.173000 4.23e-04 1.02e-01
Signaling by NOTCH4 67 3.41e-04 2.57e-03 0.2720 0.204000 0.181000 3.99e-03 1.07e-02
Telomere Maintenance 55 3.59e-04 2.69e-03 0.3200 -0.282000 0.151000 3.03e-04 5.32e-02
DNA Repair 239 3.62e-04 2.70e-03 0.1550 -0.129000 0.086100 6.25e-04 2.28e-02
Sealing of the nuclear envelope (NE) by ESCRT-III 19 4.05e-04 2.99e-03 0.5100 0.475000 0.185000 3.35e-04 1.62e-01
Processing of Capped Intron-Containing Pre-mRNA 191 4.16e-04 3.05e-03 0.1700 -0.161000 0.055700 1.42e-04 1.87e-01
RHO GTPase Effectors 184 4.20e-04 3.05e-03 0.1690 0.169000 -0.001330 8.32e-05 9.75e-01
Cellular response to hypoxia 60 4.20e-04 3.05e-03 0.2840 0.228000 0.170000 2.32e-03 2.29e-02
Resolution of Abasic Sites (AP sites) 30 4.30e-04 3.10e-03 0.4240 -0.400000 0.143000 1.53e-04 1.76e-01
Interleukin-4 and Interleukin-13 signaling 48 4.35e-04 3.12e-03 0.3180 0.154000 0.278000 6.46e-02 8.70e-04
Interactions of Rev with host cellular proteins 34 4.68e-04 3.33e-03 0.4000 -0.352000 0.190000 3.93e-04 5.54e-02
RAB geranylgeranylation 38 4.88e-04 3.46e-03 0.3660 0.366000 -0.001750 9.77e-05 9.85e-01
RHO GTPases activate CIT 14 5.08e-04 3.58e-03 0.5860 0.550000 0.203000 3.70e-04 1.88e-01
Signaling by NOTCH1 50 5.46e-04 3.82e-03 0.3080 0.282000 0.124000 5.60e-04 1.31e-01
Signalling to ERKs 26 5.63e-04 3.91e-03 0.4270 0.401000 0.147000 3.99e-04 1.95e-01
RHO GTPases activate PAKs 13 5.68e-04 3.93e-03 0.6160 0.615000 0.028300 1.23e-04 8.60e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 5.76e-04 3.96e-03 0.7280 0.616000 -0.387000 7.38e-04 3.43e-02
PCNA-Dependent Long Patch Base Excision Repair 18 6.05e-04 4.13e-03 0.5400 -0.473000 0.259000 5.08e-04 5.74e-02
TBC/RABGAPs 38 6.53e-04 4.44e-03 0.3510 0.332000 0.114000 4.10e-04 2.24e-01
Vpr-mediated nuclear import of PICs 32 6.58e-04 4.44e-03 0.4020 -0.363000 0.171000 3.77e-04 9.49e-02
tRNA modification in the nucleus and cytosol 34 6.76e-04 4.54e-03 0.3860 -0.368000 0.118000 2.10e-04 2.33e-01
Opioid Signalling 56 6.83e-04 4.54e-03 0.2940 0.293000 0.015100 1.51e-04 8.46e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 53 6.85e-04 4.54e-03 0.2930 0.186000 0.226000 1.95e-02 4.49e-03
Inositol phosphate metabolism 29 7.17e-04 4.73e-03 0.4170 0.392000 -0.142000 2.56e-04 1.88e-01
p75 NTR receptor-mediated signalling 60 7.40e-04 4.86e-03 0.2760 0.257000 0.101000 5.74e-04 1.78e-01
Interleukin-1 signaling 78 7.54e-04 4.91e-03 0.2420 0.219000 0.102000 8.56e-04 1.19e-01
Negative regulation of the PI3K/AKT network 53 7.76e-04 5.03e-03 0.2910 0.242000 0.161000 2.34e-03 4.31e-02
Base Excision Repair 36 8.06e-04 5.20e-03 0.3730 -0.341000 0.152000 4.07e-04 1.16e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 29 8.27e-04 5.22e-03 0.3970 0.388000 0.086900 3.04e-04 4.19e-01
Signaling by RAS mutants 29 8.27e-04 5.22e-03 0.3970 0.388000 0.086900 3.04e-04 4.19e-01
Signaling by moderate kinase activity BRAF mutants 29 8.27e-04 5.22e-03 0.3970 0.388000 0.086900 3.04e-04 4.19e-01
Signaling downstream of RAS mutants 29 8.27e-04 5.22e-03 0.3970 0.388000 0.086900 3.04e-04 4.19e-01
ROS sensing by NFE2L2 48 8.34e-04 5.23e-03 0.3030 0.202000 0.226000 1.55e-02 6.92e-03
Developmental Biology 449 8.44e-04 5.24e-03 0.1010 0.077200 0.065500 5.73e-03 1.90e-02
MAPK1/MAPK3 signaling 160 8.45e-04 5.24e-03 0.1670 0.128000 0.107000 5.38e-03 2.03e-02
Growth hormone receptor signaling 17 8.51e-04 5.25e-03 0.5080 0.398000 0.316000 4.53e-03 2.43e-02
Uptake and function of anthrax toxins 10 8.93e-04 5.49e-03 0.6640 0.592000 0.299000 1.18e-03 1.02e-01
Synthesis of DNA 103 9.04e-04 5.52e-03 0.2220 -0.160000 0.153000 5.08e-03 7.38e-03
Transcriptional regulation by RUNX3 75 9.52e-04 5.79e-03 0.2400 0.160000 0.180000 1.69e-02 7.31e-03
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 33 1.00e-03 6.05e-03 0.3790 0.369000 -0.085800 2.42e-04 3.94e-01
DNA Replication 110 1.02e-03 6.11e-03 0.2130 -0.143000 0.158000 9.86e-03 4.42e-03
SARS-CoV-2 Infection 56 1.02e-03 6.11e-03 0.2770 0.178000 0.211000 2.12e-02 6.27e-03
COPII-mediated vesicle transport 51 1.03e-03 6.14e-03 0.3020 0.301000 -0.023500 2.08e-04 7.72e-01
VEGFA-VEGFR2 Pathway 71 1.13e-03 6.68e-03 0.2550 0.253000 -0.035400 2.37e-04 6.07e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 47 1.15e-03 6.76e-03 0.3010 0.272000 0.129000 1.26e-03 1.26e-01
BBSome-mediated cargo-targeting to cilium 19 1.16e-03 6.81e-03 0.4730 -0.422000 -0.213000 1.46e-03 1.09e-01
MAPK6/MAPK4 signaling 66 1.17e-03 6.86e-03 0.2520 0.159000 0.196000 2.58e-02 5.97e-03
Transport of the SLBP independent Mature mRNA 33 1.25e-03 7.16e-03 0.3810 -0.305000 0.228000 2.46e-03 2.36e-02
MyD88 cascade initiated on plasma membrane 65 1.25e-03 7.16e-03 0.2640 0.262000 -0.029100 2.59e-04 6.85e-01
Toll Like Receptor 10 (TLR10) Cascade 65 1.25e-03 7.16e-03 0.2640 0.262000 -0.029100 2.59e-04 6.85e-01
Toll Like Receptor 5 (TLR5) Cascade 65 1.25e-03 7.16e-03 0.2640 0.262000 -0.029100 2.59e-04 6.85e-01
G beta:gamma signalling through PI3Kgamma 16 1.28e-03 7.31e-03 0.5090 0.422000 0.284000 3.47e-03 4.92e-02
Metabolism of carbohydrates 177 1.30e-03 7.34e-03 0.1600 0.160000 -0.004310 2.70e-04 9.22e-01
Degradation of beta-catenin by the destruction complex 68 1.34e-03 7.53e-03 0.2460 0.164000 0.183000 1.94e-02 9.07e-03
NEP/NS2 Interacts with the Cellular Export Machinery 30 1.35e-03 7.56e-03 0.3950 -0.349000 0.185000 9.57e-04 7.95e-02
Prolonged ERK activation events 13 1.36e-03 7.60e-03 0.5630 0.488000 0.280000 2.30e-03 8.04e-02
Sphingolipid metabolism 50 1.37e-03 7.62e-03 0.3020 0.290000 -0.086800 4.01e-04 2.89e-01
GPVI-mediated activation cascade 24 1.38e-03 7.62e-03 0.4190 0.403000 0.115000 6.34e-04 3.30e-01
Cellular response to chemical stress 116 1.45e-03 8.00e-03 0.1930 0.191000 0.022600 3.84e-04 6.76e-01
Detoxification of Reactive Oxygen Species 23 1.47e-03 8.05e-03 0.4440 0.420000 -0.143000 4.88e-04 2.35e-01
MyD88 dependent cascade initiated on endosome 67 1.52e-03 8.24e-03 0.2560 0.255000 -0.025600 3.16e-04 7.18e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 67 1.52e-03 8.24e-03 0.2560 0.255000 -0.025600 3.16e-04 7.18e-01
Transport of the SLBP Dependant Mature mRNA 34 1.64e-03 8.87e-03 0.3670 -0.303000 0.207000 2.27e-03 3.69e-02
Mitochondrial protein import 47 1.71e-03 9.19e-03 0.3050 -0.299000 0.056600 3.92e-04 5.03e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 66 1.72e-03 9.19e-03 0.2560 0.254000 -0.029000 3.63e-04 6.85e-01
Lagging Strand Synthesis 17 1.75e-03 9.34e-03 0.5050 -0.496000 0.095400 4.05e-04 4.96e-01
Neuronal System 128 1.79e-03 9.44e-03 0.1890 0.149000 -0.116000 3.68e-03 2.40e-02
Sema4D in semaphorin signaling 15 1.79e-03 9.44e-03 0.5180 0.491000 0.163000 9.85e-04 2.73e-01
Collagen degradation 14 1.80e-03 9.44e-03 0.5440 0.541000 0.053100 4.57e-04 7.31e-01
Oncogenic MAPK signaling 56 1.81e-03 9.46e-03 0.2740 0.274000 -0.002260 3.90e-04 9.77e-01
Regulation of signaling by CBL 14 1.84e-03 9.55e-03 0.5280 0.364000 0.382000 1.83e-02 1.34e-02
Degradation of DVL 48 1.84e-03 9.55e-03 0.2860 0.158000 0.238000 5.80e-02 4.32e-03
G alpha (12/13) signalling events 40 1.86e-03 9.60e-03 0.3170 0.302000 0.096600 9.68e-04 2.91e-01
Signaling by VEGF 73 1.90e-03 9.76e-03 0.2420 0.240000 -0.032400 4.12e-04 6.33e-01
ROS and RNS production in phagocytes 23 1.91e-03 9.76e-03 0.4340 0.417000 -0.121000 5.47e-04 3.14e-01
G1/S Transition 113 1.93e-03 9.82e-03 0.2000 -0.137000 0.145000 1.19e-02 7.80e-03
RAF/MAP kinase cascade 155 1.94e-03 9.83e-03 0.1590 0.121000 0.104000 9.83e-03 2.64e-02
Post-translational protein phosphorylation 32 2.07e-03 1.04e-02 0.3630 0.358000 -0.057100 4.61e-04 5.77e-01
Transferrin endocytosis and recycling 19 2.09e-03 1.05e-02 0.4750 0.449000 -0.155000 7.01e-04 2.43e-01
Insulin receptor recycling 17 2.11e-03 1.05e-02 0.4940 0.492000 -0.049100 4.49e-04 7.26e-01
Toll Like Receptor 9 (TLR9) Cascade 70 2.16e-03 1.08e-02 0.2420 0.242000 -0.006100 4.67e-04 9.30e-01
Signaling by BRAF and RAF fusions 42 2.22e-03 1.10e-02 0.3090 0.308000 0.025800 5.52e-04 7.72e-01
Neurotransmitter receptors and postsynaptic signal transmission 73 2.23e-03 1.10e-02 0.2400 0.235000 -0.050800 5.43e-04 4.54e-01
Transmission across Chemical Synapses 95 2.34e-03 1.15e-02 0.2130 0.194000 -0.086600 1.12e-03 1.46e-01
Amino acids regulate mTORC1 43 2.36e-03 1.16e-02 0.3020 0.296000 0.061000 8.08e-04 4.89e-01
PI3K/AKT Signaling in Cancer 50 2.45e-03 1.20e-02 0.2730 0.208000 0.177000 1.10e-02 3.03e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 27 2.49e-03 1.21e-02 0.3750 0.347000 0.142000 1.83e-03 2.01e-01
RHOQ GTPase cycle 39 2.50e-03 1.21e-02 0.3300 0.293000 -0.152000 1.59e-03 1.01e-01
Lysosome Vesicle Biogenesis 25 2.59e-03 1.25e-02 0.4050 0.394000 -0.093500 6.62e-04 4.19e-01
Regulation of HSF1-mediated heat shock response 66 2.62e-03 1.25e-02 0.2550 -0.180000 0.180000 1.15e-02 1.17e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 2.63e-03 1.25e-02 0.4360 0.419000 0.121000 1.19e-03 3.51e-01
Neurodegenerative Diseases 20 2.63e-03 1.25e-02 0.4360 0.419000 0.121000 1.19e-03 3.51e-01
Postmitotic nuclear pore complex (NPC) reformation 26 2.73e-03 1.30e-02 0.3950 -0.383000 0.097000 7.23e-04 3.92e-01
Glycerophospholipid biosynthesis 71 2.76e-03 1.30e-02 0.2410 0.229000 -0.073000 8.60e-04 2.89e-01
Nuclear Events (kinase and transcription factor activation) 43 2.85e-03 1.34e-02 0.3020 0.302000 -0.014900 6.21e-04 8.66e-01
Transcriptional regulation by RUNX2 82 2.92e-03 1.37e-02 0.2110 0.140000 0.157000 2.84e-02 1.41e-02
HIV Infection 188 2.98e-03 1.39e-02 0.1440 0.005790 0.144000 8.92e-01 7.00e-04
Extracellular matrix organization 91 2.99e-03 1.39e-02 0.2090 0.207000 -0.026200 6.63e-04 6.67e-01
Cellular response to heat stress 79 3.00e-03 1.39e-02 0.2300 -0.160000 0.165000 1.40e-02 1.13e-02
RNA Polymerase I Transcription Initiation 38 3.04e-03 1.40e-02 0.3300 -0.277000 0.179000 3.18e-03 5.63e-02
Transcriptional regulation by small RNAs 43 3.07e-03 1.41e-02 0.3110 -0.214000 0.225000 1.53e-02 1.06e-02
Regulation of RUNX3 expression and activity 49 3.19e-03 1.46e-02 0.2720 0.129000 0.239000 1.18e-01 3.88e-03
Regulation of ornithine decarboxylase (ODC) 43 3.20e-03 1.46e-02 0.2880 0.178000 0.227000 4.34e-02 1.02e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 28 3.48e-03 1.57e-02 0.3780 -0.335000 0.175000 2.16e-03 1.10e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 28 3.48e-03 1.57e-02 0.3780 -0.335000 0.175000 2.16e-03 1.10e-01
Negative regulation of NOTCH4 signaling 48 3.49e-03 1.57e-02 0.2720 0.146000 0.229000 8.02e-02 6.17e-03
Nuclear import of Rev protein 31 3.60e-03 1.61e-02 0.3570 -0.326000 0.147000 1.71e-03 1.58e-01
Apoptosis 132 3.63e-03 1.62e-02 0.1660 0.158000 0.049700 1.77e-03 3.26e-01
RHOG GTPase cycle 51 3.70e-03 1.64e-02 0.2660 0.260000 0.058000 1.33e-03 4.75e-01
Arachidonic acid metabolism 20 3.85e-03 1.70e-02 0.4460 0.281000 -0.346000 2.94e-02 7.47e-03
Regulation of RUNX2 expression and activity 57 3.86e-03 1.70e-02 0.2510 0.061400 0.243000 4.23e-01 1.53e-03
NS1 Mediated Effects on Host Pathways 38 3.92e-03 1.72e-02 0.3220 -0.275000 0.168000 3.41e-03 7.34e-02
Anti-inflammatory response favouring Leishmania parasite infection 51 3.95e-03 1.72e-02 0.2700 0.270000 -0.010500 8.84e-04 8.97e-01
Leishmania parasite growth and survival 51 3.95e-03 1.72e-02 0.2700 0.270000 -0.010500 8.84e-04 8.97e-01
RHOJ GTPase cycle 36 4.03e-03 1.75e-02 0.3260 0.310000 -0.102000 1.30e-03 2.92e-01
Signaling by MET 42 4.06e-03 1.76e-02 0.2880 0.268000 0.106000 2.66e-03 2.35e-01
Hedgehog ‘on’ state 61 4.08e-03 1.76e-02 0.2370 0.161000 0.174000 3.04e-02 1.88e-02
Platelet homeostasis 47 4.11e-03 1.76e-02 0.2800 0.280000 -0.014100 9.19e-04 8.67e-01
Platelet sensitization by LDL 13 4.12e-03 1.76e-02 0.5220 0.511000 0.106000 1.41e-03 5.10e-01
O-linked glycosylation of mucins 26 4.28e-03 1.82e-02 0.3870 0.320000 -0.217000 4.78e-03 5.55e-02
Death Receptor Signalling 96 4.29e-03 1.82e-02 0.1910 0.179000 0.065800 2.52e-03 2.67e-01
Recognition of DNA damage by PCNA-containing replication complex 26 4.32e-03 1.83e-02 0.3830 -0.352000 0.151000 1.90e-03 1.82e-01
Signal amplification 19 4.36e-03 1.83e-02 0.4260 0.401000 0.144000 2.48e-03 2.78e-01
MyD88-independent TLR4 cascade 75 4.38e-03 1.83e-02 0.2170 0.211000 0.047700 1.59e-03 4.76e-01
TRIF(TICAM1)-mediated TLR4 signaling 75 4.38e-03 1.83e-02 0.2170 0.211000 0.047700 1.59e-03 4.76e-01
p53-Dependent G1 DNA Damage Response 55 4.40e-03 1.83e-02 0.2520 0.064800 0.244000 4.07e-01 1.81e-03
p53-Dependent G1/S DNA damage checkpoint 55 4.40e-03 1.83e-02 0.2520 0.064800 0.244000 4.07e-01 1.81e-03
Signaling by Erythropoietin 20 4.46e-03 1.84e-02 0.4130 0.380000 0.162000 3.24e-03 2.11e-01
Regulation of IFNG signaling 13 4.46e-03 1.84e-02 0.5110 0.450000 0.241000 4.94e-03 1.33e-01
Export of Viral Ribonucleoproteins from Nucleus 31 4.75e-03 1.96e-02 0.3490 -0.313000 0.154000 2.58e-03 1.37e-01
Cellular responses to external stimuli 457 4.78e-03 1.96e-02 0.0902 0.001570 0.090200 9.55e-01 1.13e-03
Interleukin-17 signaling 53 4.81e-03 1.97e-02 0.2660 0.244000 -0.107000 2.17e-03 1.78e-01
ADP signalling through P2Y purinoceptor 12 12 4.88e-03 1.99e-02 0.5240 0.385000 0.355000 2.09e-02 3.32e-02
Activated NOTCH1 Transmits Signal to the Nucleus 19 4.98e-03 2.02e-02 0.4220 0.402000 0.129000 2.44e-03 3.32e-01
Cellular responses to stress 452 5.01e-03 2.03e-02 0.0907 -0.004570 0.090600 8.70e-01 1.14e-03
Class A/1 (Rhodopsin-like receptors) 40 5.09e-03 2.05e-02 0.3080 0.238000 -0.194000 9.16e-03 3.36e-02
Recycling pathway of L1 16 5.12e-03 2.06e-02 0.4710 0.469000 -0.044700 1.17e-03 7.57e-01
Class I MHC mediated antigen processing & presentation 282 5.15e-03 2.06e-02 0.1110 0.109000 0.023000 1.79e-03 5.11e-01
DNA Replication Pre-Initiation 72 5.21e-03 2.08e-02 0.2280 -0.103000 0.203000 1.33e-01 2.93e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript 54 5.26e-03 2.09e-02 0.2640 -0.195000 0.178000 1.34e-02 2.35e-02
Signaling by CSF3 (G-CSF) 24 5.30e-03 2.10e-02 0.3730 0.355000 0.115000 2.61e-03 3.32e-01
Deubiquitination 192 5.46e-03 2.16e-02 0.1320 0.116000 0.062600 5.96e-03 1.37e-01
Other semaphorin interactions 10 5.57e-03 2.19e-02 0.6090 0.466000 -0.393000 1.08e-02 3.16e-02
Cross-presentation of soluble exogenous antigens (endosomes) 38 5.61e-03 2.20e-02 0.2920 0.169000 0.238000 7.25e-02 1.13e-02
Hedgehog ligand biogenesis 51 5.68e-03 2.22e-02 0.2510 0.189000 0.166000 1.99e-02 4.09e-02
Defective CFTR causes cystic fibrosis 52 5.69e-03 2.22e-02 0.2490 0.183000 0.168000 2.24e-02 3.64e-02
SUMO E3 ligases SUMOylate target proteins 130 5.81e-03 2.25e-02 0.1690 -0.109000 0.130000 3.31e-02 1.09e-02
Transport of Mature mRNA Derived from an Intronless Transcript 40 5.92e-03 2.29e-02 0.3030 -0.237000 0.189000 9.55e-03 3.90e-02
tRNA Aminoacylation 23 5.99e-03 2.31e-02 0.3770 -0.360000 -0.111000 2.81e-03 3.55e-01
AKT phosphorylates targets in the cytosol 13 6.07e-03 2.33e-02 0.5060 0.501000 0.070500 1.78e-03 6.60e-01
SUMOylation 136 6.08e-03 2.33e-02 0.1650 -0.114000 0.119000 2.19e-02 1.71e-02
Cargo concentration in the ER 20 6.15e-03 2.35e-02 0.4050 0.395000 0.089100 2.23e-03 4.91e-01
SUMOylation of DNA damage response and repair proteins 67 6.20e-03 2.36e-02 0.2330 -0.199000 0.120000 4.92e-03 8.88e-02
Vif-mediated degradation of APOBEC3G 43 6.39e-03 2.42e-02 0.2710 0.140000 0.232000 1.13e-01 8.44e-03
Transport of Ribonucleoproteins into the Host Nucleus 30 6.44e-03 2.44e-02 0.3450 -0.303000 0.165000 4.10e-03 1.18e-01
Activation of gene expression by SREBF (SREBP) 34 6.58e-03 2.48e-02 0.3240 0.277000 -0.169000 5.27e-03 8.88e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 6.73e-03 2.53e-02 0.2720 0.159000 0.221000 7.42e-02 1.34e-02
Erythropoietin activates RAS 11 6.76e-03 2.53e-02 0.5320 0.457000 0.273000 8.72e-03 1.16e-01
Glycosaminoglycan metabolism 61 6.79e-03 2.53e-02 0.2350 0.234000 -0.016300 1.58e-03 8.26e-01
Degradation of GLI1 by the proteasome 51 6.82e-03 2.54e-02 0.2470 0.148000 0.198000 6.83e-02 1.47e-02
Signaling by Insulin receptor 42 6.97e-03 2.58e-02 0.2760 0.270000 0.059100 2.48e-03 5.08e-01
Thrombin signalling through proteinase activated receptors (PARs) 19 7.09e-03 2.62e-02 0.4100 0.400000 0.088700 2.55e-03 5.04e-01
Ubiquitin-dependent degradation of Cyclin D 44 7.16e-03 2.64e-02 0.2660 0.121000 0.237000 1.67e-01 6.64e-03
Transport of Mature mRNAs Derived from Intronless Transcripts 41 7.24e-03 2.66e-02 0.2930 -0.237000 0.173000 8.71e-03 5.62e-02
Budding and maturation of HIV virion 24 7.42e-03 2.72e-02 0.3600 0.338000 0.125000 4.20e-03 2.90e-01
Asymmetric localization of PCP proteins 51 7.47e-03 2.73e-02 0.2460 0.099700 0.225000 2.19e-01 5.42e-03
Fanconi Anemia Pathway 28 7.53e-03 2.74e-02 0.3410 -0.341000 0.000980 1.81e-03 9.93e-01
Regulation of Apoptosis 45 7.68e-03 2.78e-02 0.2600 0.135000 0.222000 1.17e-01 9.96e-03
HDR through Homologous Recombination (HRR) 58 7.69e-03 2.78e-02 0.2400 -0.235000 0.051100 2.02e-03 5.02e-01
Positive epigenetic regulation of rRNA expression 37 7.71e-03 2.78e-02 0.3070 -0.209000 0.225000 2.78e-02 1.80e-02
WNT5A-dependent internalization of FZD4 10 7.72e-03 2.78e-02 0.5560 0.525000 0.183000 4.05e-03 3.17e-01
RHO GTPases Activate NADPH Oxidases 14 7.97e-03 2.85e-02 0.4720 0.461000 0.098500 2.80e-03 5.24e-01
Hyaluronan uptake and degradation 10 7.99e-03 2.85e-02 0.5660 0.566000 -0.000604 1.93e-03 9.97e-01
G1/S DNA Damage Checkpoints 57 8.06e-03 2.87e-02 0.2340 0.053400 0.228000 4.86e-01 3.00e-03
Formation of the beta-catenin:TCF transactivating complex 24 8.41e-03 2.98e-02 0.3590 0.064200 0.353000 5.87e-01 2.74e-03
G beta:gamma signalling through CDC42 12 8.60e-03 3.04e-02 0.4960 0.383000 0.314000 2.16e-02 5.94e-02
Viral Messenger RNA Synthesis 40 8.64e-03 3.05e-02 0.2920 -0.227000 0.183000 1.29e-02 4.57e-02
Cell Cycle 515 9.03e-03 3.18e-02 0.0832 -0.061800 0.055600 1.81e-02 3.37e-02
Transport of bile salts and organic acids, metal ions and amine compounds 30 9.09e-03 3.18e-02 0.3290 0.318000 -0.082200 2.58e-03 4.36e-01
DNA Double-Strand Break Repair 113 9.10e-03 3.18e-02 0.1730 -0.138000 0.105000 1.15e-02 5.56e-02
Beta-catenin phosphorylation cascade 15 9.11e-03 3.18e-02 0.4470 0.429000 0.126000 4.00e-03 3.99e-01
G alpha (q) signalling events 72 9.21e-03 3.20e-02 0.2080 0.207000 0.013200 2.41e-03 8.46e-01
Notch-HLH transcription pathway 21 9.29e-03 3.22e-02 0.3800 0.375000 0.065200 2.98e-03 6.05e-01
mRNA Splicing - Major Pathway 144 9.31e-03 3.22e-02 0.1500 -0.147000 0.030600 2.44e-03 5.28e-01
Regulation of HMOX1 expression and activity 55 9.35e-03 3.22e-02 0.2300 0.172000 0.152000 2.74e-02 5.11e-02
Processive synthesis on the lagging strand 13 9.45e-03 3.25e-02 0.4900 -0.489000 0.029800 2.26e-03 8.52e-01
Autophagy 104 9.53e-03 3.26e-02 0.1750 0.173000 -0.023300 2.33e-03 6.83e-01
Translesion synthesis by POLI 15 9.64e-03 3.26e-02 0.4700 -0.371000 0.289000 1.30e-02 5.26e-02
Golgi Cisternae Pericentriolar Stack Reorganization 14 9.64e-03 3.26e-02 0.4760 0.466000 -0.101000 2.57e-03 5.13e-01
MAP kinase activation 50 9.67e-03 3.26e-02 0.2540 0.240000 -0.083400 3.32e-03 3.09e-01
XBP1(S) activates chaperone genes 36 9.75e-03 3.26e-02 0.2920 0.292000 0.007140 2.45e-03 9.41e-01
Toll Like Receptor 3 (TLR3) Cascade 75 9.76e-03 3.26e-02 0.2000 0.196000 0.041600 3.43e-03 5.35e-01
mRNA Splicing 151 9.78e-03 3.26e-02 0.1450 -0.143000 0.024200 2.46e-03 6.10e-01
Peptide hormone metabolism 26 9.78e-03 3.26e-02 0.3320 0.231000 0.239000 4.18e-02 3.51e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 44 9.79e-03 3.26e-02 0.2570 0.122000 0.226000 1.62e-01 9.54e-03
p53-Independent DNA Damage Response 44 9.79e-03 3.26e-02 0.2570 0.122000 0.226000 1.62e-01 9.54e-03
p53-Independent G1/S DNA damage checkpoint 44 9.79e-03 3.26e-02 0.2570 0.122000 0.226000 1.62e-01 9.54e-03
G-protein mediated events 32 9.97e-03 3.31e-02 0.3170 0.298000 -0.107000 3.54e-03 2.94e-01
Phosphorylation of CD3 and TCR zeta chains 10 1.01e-02 3.32e-02 0.5590 -0.083000 0.552000 6.50e-01 2.49e-03
SUMOylation of SUMOylation proteins 32 1.02e-02 3.35e-02 0.3190 -0.272000 0.167000 7.76e-03 1.02e-01
Peptide ligand-binding receptors 16 1.05e-02 3.46e-02 0.4510 0.364000 -0.265000 1.17e-02 6.64e-02
Hyaluronan metabolism 11 1.05e-02 3.46e-02 0.5290 0.525000 -0.068500 2.59e-03 6.94e-01
RHOF GTPase cycle 25 1.06e-02 3.48e-02 0.3360 0.233000 0.242000 4.42e-02 3.64e-02
Unwinding of DNA 10 1.09e-02 3.55e-02 0.5560 -0.544000 0.112000 2.88e-03 5.41e-01
Nucleobase biosynthesis 10 1.09e-02 3.55e-02 0.5500 -0.549000 0.037600 2.65e-03 8.37e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 10 1.11e-02 3.61e-02 0.5650 -0.288000 0.486000 1.15e-01 7.83e-03
Translesion synthesis by REV1 14 1.12e-02 3.62e-02 0.4770 -0.405000 0.253000 8.76e-03 1.01e-01
Transport of Mature Transcript to Cytoplasm 63 1.14e-02 3.65e-02 0.2260 -0.160000 0.160000 2.85e-02 2.84e-02
MTOR signalling 37 1.14e-02 3.65e-02 0.2790 0.272000 0.064700 4.28e-03 4.96e-01
FLT3 Signaling 33 1.14e-02 3.65e-02 0.2900 0.205000 0.205000 4.15e-02 4.17e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 1.14e-02 3.66e-02 0.2470 0.132000 0.208000 1.22e-01 1.46e-02
EGFR downregulation 20 1.16e-02 3.69e-02 0.3850 0.385000 0.004960 2.92e-03 9.69e-01
Assembly of the pre-replicative complex 59 1.17e-02 3.73e-02 0.2230 0.013900 0.223000 8.53e-01 3.12e-03
FCERI mediated MAPK activation 25 1.19e-02 3.76e-02 0.3450 0.344000 -0.024500 2.90e-03 8.32e-01
SLC-mediated transmembrane transport 97 1.19e-02 3.78e-02 0.1810 0.153000 -0.097000 9.55e-03 9.98e-02
SUMOylation of RNA binding proteins 42 1.21e-02 3.81e-02 0.2700 -0.258000 0.081700 3.90e-03 3.60e-01
Muscle contraction 62 1.22e-02 3.84e-02 0.2260 0.181000 -0.135000 1.38e-02 6.70e-02
G beta:gamma signalling through BTK 10 1.23e-02 3.86e-02 0.5220 0.311000 0.420000 8.90e-02 2.15e-02
Antigen processing-Cross presentation 77 1.23e-02 3.86e-02 0.1920 0.187000 0.043200 4.56e-03 5.13e-01
Sema4D induced cell migration and growth-cone collapse 12 1.24e-02 3.86e-02 0.4860 0.475000 0.100000 4.36e-03 5.48e-01
Regulation of RAS by GAPs 56 1.24e-02 3.87e-02 0.2210 0.134000 0.176000 8.26e-02 2.33e-02
Hh mutants are degraded by ERAD 47 1.26e-02 3.90e-02 0.2410 0.183000 0.156000 3.00e-02 6.47e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 23 1.26e-02 3.90e-02 0.3640 -0.342000 0.124000 4.51e-03 3.04e-01
Neddylation 179 1.27e-02 3.92e-02 0.1240 0.067500 0.105000 1.22e-01 1.65e-02
Stabilization of p53 48 1.29e-02 3.96e-02 0.2400 0.090700 0.222000 2.78e-01 7.85e-03
ERK/MAPK targets 17 1.30e-02 4.01e-02 0.4190 0.407000 -0.100000 3.71e-03 4.73e-01
ADP signalling through P2Y purinoceptor 1 15 1.31e-02 4.01e-02 0.4310 0.418000 0.104000 5.06e-03 4.87e-01
Cell death signalling via NRAGE, NRIF and NADE 46 1.32e-02 4.01e-02 0.2490 0.248000 0.019200 3.62e-03 8.22e-01
Homologous DNA Pairing and Strand Exchange 38 1.33e-02 4.01e-02 0.2780 -0.276000 0.033800 3.32e-03 7.19e-01
HIV Life Cycle 127 1.34e-02 4.01e-02 0.1560 -0.067900 0.140000 1.88e-01 6.63e-03
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 40 1.34e-02 4.01e-02 0.2610 0.241000 0.101000 8.40e-03 2.70e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 40 1.34e-02 4.01e-02 0.2610 0.241000 0.101000 8.40e-03 2.70e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 40 1.34e-02 4.01e-02 0.2610 0.241000 0.101000 8.40e-03 2.70e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 40 1.34e-02 4.01e-02 0.2610 0.241000 0.101000 8.40e-03 2.70e-01
Signaling by NOTCH1 in Cancer 40 1.34e-02 4.01e-02 0.2610 0.241000 0.101000 8.40e-03 2.70e-01
Mitochondrial tRNA aminoacylation 18 1.34e-02 4.02e-02 0.3890 -0.355000 -0.158000 9.20e-03 2.45e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 1.35e-02 4.02e-02 0.2410 0.151000 0.189000 7.77e-02 2.70e-02
Dual Incision in GG-NER 35 1.35e-02 4.03e-02 0.2900 -0.285000 0.048400 3.50e-03 6.20e-01
CDK-mediated phosphorylation and removal of Cdc6 62 1.36e-02 4.03e-02 0.2110 0.060700 0.202000 4.09e-01 6.03e-03
Regulation of insulin secretion 38 1.36e-02 4.03e-02 0.2830 0.252000 -0.128000 7.26e-03 1.71e-01
Energy dependent regulation of mTOR by LKB1-AMPK 26 1.37e-02 4.05e-02 0.3310 0.331000 0.006740 3.54e-03 9.53e-01
Autodegradation of the E3 ubiquitin ligase COP1 43 1.37e-02 4.05e-02 0.2510 0.101000 0.230000 2.53e-01 9.16e-03
Host Interactions of HIV factors 106 1.38e-02 4.07e-02 0.1690 -0.065000 0.156000 2.49e-01 5.69e-03
Plasma lipoprotein assembly, remodeling, and clearance 32 1.43e-02 4.18e-02 0.2920 0.280000 0.080400 6.11e-03 4.32e-01
Degradation of GLI2 by the proteasome 50 1.43e-02 4.18e-02 0.2300 0.132000 0.188000 1.06e-01 2.14e-02
GLI3 is processed to GLI3R by the proteasome 50 1.43e-02 4.18e-02 0.2300 0.132000 0.188000 1.06e-01 2.14e-02
SUMOylation of chromatin organization proteins 49 1.44e-02 4.18e-02 0.2480 -0.221000 0.112000 7.63e-03 1.74e-01
Transcriptional regulation of white adipocyte differentiation 55 1.44e-02 4.18e-02 0.2290 0.227000 -0.026100 3.62e-03 7.39e-01
IRE1alpha activates chaperones 37 1.47e-02 4.25e-02 0.2740 0.273000 0.025500 4.16e-03 7.89e-01
GABA receptor activation 18 1.47e-02 4.25e-02 0.3860 0.366000 0.122000 7.13e-03 3.70e-01
Integrin signaling 17 1.48e-02 4.26e-02 0.4100 0.406000 -0.057000 3.79e-03 6.84e-01
Platelet Aggregation (Plug Formation) 17 1.48e-02 4.26e-02 0.4100 0.406000 -0.057000 3.79e-03 6.84e-01
VxPx cargo-targeting to cilium 16 1.50e-02 4.29e-02 0.4080 0.380000 0.148000 8.52e-03 3.07e-01
UCH proteinases 74 1.50e-02 4.29e-02 0.1880 0.131000 0.135000 5.16e-02 4.55e-02
Smooth Muscle Contraction 19 1.51e-02 4.29e-02 0.3900 0.378000 -0.096500 4.38e-03 4.67e-01
Frs2-mediated activation 11 1.52e-02 4.33e-02 0.4880 0.428000 0.234000 1.39e-02 1.80e-01
SUMOylation of ubiquitinylation proteins 37 1.58e-02 4.49e-02 0.2840 -0.186000 0.214000 5.00e-02 2.47e-02
Glucagon signaling in metabolic regulation 17 1.59e-02 4.49e-02 0.4080 0.400000 -0.082300 4.33e-03 5.57e-01
Switching of origins to a post-replicative state 79 1.59e-02 4.49e-02 0.1920 -0.063800 0.181000 3.28e-01 5.60e-03
Post-chaperonin tubulin folding pathway 13 1.61e-02 4.53e-02 0.4480 0.411000 0.177000 1.03e-02 2.70e-01
Constitutive Signaling by Aberrant PI3K in Cancer 26 1.63e-02 4.56e-02 0.3150 0.156000 0.273000 1.68e-01 1.60e-02
Synthesis of IP3 and IP4 in the cytosol 15 1.63e-02 4.56e-02 0.4380 0.406000 -0.163000 6.44e-03 2.74e-01
G beta:gamma signalling through PLC beta 12 1.64e-02 4.56e-02 0.4620 0.390000 0.248000 1.95e-02 1.36e-01
Presynaptic function of Kainate receptors 12 1.64e-02 4.56e-02 0.4620 0.390000 0.248000 1.95e-02 1.36e-01
Glycosphingolipid metabolism 27 1.64e-02 4.58e-02 0.3200 0.319000 -0.031900 4.17e-03 7.74e-01
COPI-dependent Golgi-to-ER retrograde traffic 64 1.66e-02 4.62e-02 0.2070 0.207000 -0.000207 4.30e-03 9.98e-01
CDT1 association with the CDC6:ORC:origin complex 50 1.69e-02 4.69e-02 0.2290 0.054500 0.223000 5.06e-01 6.48e-03
NRAGE signals death through JNK 31 1.71e-02 4.73e-02 0.2920 0.287000 0.054200 5.81e-03 6.02e-01
GPCR ligand binding 67 1.71e-02 4.73e-02 0.2070 0.190000 -0.081800 7.28e-03 2.48e-01
Mitotic G1 phase and G1/S transition 127 1.75e-02 4.81e-02 0.1520 -0.096300 0.117000 6.18e-02 2.29e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 45 1.78e-02 4.88e-02 0.2470 0.244000 -0.041800 4.72e-03 6.28e-01
EPH-ephrin mediated repulsion of cells 25 1.79e-02 4.91e-02 0.3200 0.303000 0.102000 8.68e-03 3.78e-01
Orc1 removal from chromatin 61 1.84e-02 5.02e-02 0.2130 -0.051200 0.206000 4.90e-01 5.36e-03
Epigenetic regulation of gene expression 72 1.88e-02 5.13e-02 0.1990 -0.119000 0.160000 8.24e-02 1.93e-02
Processive synthesis on the C-strand of the telomere 17 1.89e-02 5.15e-02 0.4080 -0.329000 0.241000 1.89e-02 8.50e-02
RNA Polymerase I Promoter Clearance 41 1.91e-02 5.16e-02 0.2630 -0.219000 0.145000 1.55e-02 1.08e-01
RNA Polymerase I Transcription 41 1.91e-02 5.16e-02 0.2630 -0.219000 0.145000 1.55e-02 1.08e-01
Signaling by NOTCH3 29 1.95e-02 5.26e-02 0.2950 0.285000 0.078400 8.05e-03 4.65e-01
ESR-mediated signaling 112 1.99e-02 5.35e-02 0.1480 0.086700 0.120000 1.14e-01 2.84e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 25 2.01e-02 5.39e-02 0.3340 -0.271000 0.195000 1.89e-02 9.21e-02
Late Phase of HIV Life Cycle 115 2.03e-02 5.42e-02 0.1540 -0.041700 0.148000 4.41e-01 6.30e-03
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 10 2.03e-02 5.42e-02 0.5020 0.492000 0.096800 7.05e-03 5.96e-01
C-type lectin receptors (CLRs) 100 2.04e-02 5.42e-02 0.1560 0.127000 0.091700 2.92e-02 1.14e-01
O-linked glycosylation 42 2.04e-02 5.42e-02 0.2560 0.116000 -0.228000 1.94e-01 1.06e-02
Gap-filling DNA repair synthesis and ligation in TC-NER 54 2.04e-02 5.42e-02 0.2270 -0.189000 0.126000 1.64e-02 1.11e-01
Ca2+ pathway 39 2.05e-02 5.43e-02 0.2490 0.150000 0.199000 1.05e-01 3.18e-02
ER-Phagosome pathway 69 2.15e-02 5.67e-02 0.1870 0.165000 0.088900 1.81e-02 2.02e-01
Thromboxane signalling through TP receptor 14 2.15e-02 5.68e-02 0.4130 0.336000 0.240000 2.98e-02 1.20e-01
RAC3 GTPase cycle 59 2.17e-02 5.71e-02 0.2120 0.205000 -0.054000 6.57e-03 4.74e-01
Presynaptic phase of homologous DNA pairing and strand exchange 35 2.17e-02 5.71e-02 0.2710 -0.271000 0.018100 5.65e-03 8.53e-01
Macroautophagy 95 2.20e-02 5.76e-02 0.1650 0.164000 -0.014700 5.73e-03 8.05e-01
Hh mutants abrogate ligand secretion 48 2.21e-02 5.78e-02 0.2220 0.170000 0.143000 4.15e-02 8.73e-02
G-protein activation 12 2.22e-02 5.79e-02 0.4470 0.406000 0.188000 1.50e-02 2.61e-01
G alpha (z) signalling events 24 2.24e-02 5.82e-02 0.3150 0.272000 0.159000 2.13e-02 1.79e-01
TNFR2 non-canonical NF-kB pathway 67 2.24e-02 5.82e-02 0.1900 0.064200 0.179000 3.65e-01 1.14e-02
Nervous system development 305 2.25e-02 5.82e-02 0.0901 0.033700 0.083600 3.15e-01 1.29e-02
Signaling by the B Cell Receptor (BCR) 91 2.26e-02 5.85e-02 0.1620 0.076600 0.143000 2.08e-01 1.88e-02
Degradation of AXIN 47 2.29e-02 5.89e-02 0.2240 0.119000 0.190000 1.58e-01 2.44e-02
PLC beta mediated events 29 2.29e-02 5.89e-02 0.3030 0.274000 -0.128000 1.06e-02 2.33e-01
Extra-nuclear estrogen signaling 48 2.29e-02 5.89e-02 0.2210 0.152000 0.161000 6.98e-02 5.39e-02
Prostacyclin signalling through prostacyclin receptor 11 2.32e-02 5.95e-02 0.4600 0.322000 0.329000 6.45e-02 5.91e-02
Termination of translesion DNA synthesis 28 2.34e-02 5.99e-02 0.3070 -0.279000 0.129000 1.08e-02 2.37e-01
Gap junction trafficking and regulation 10 2.35e-02 5.99e-02 0.5100 0.483000 -0.165000 8.19e-03 3.66e-01
MicroRNA (miRNA) biogenesis 20 2.39e-02 6.08e-02 0.3590 -0.099000 0.345000 4.44e-01 7.54e-03
SARS-CoV-1 Infection 43 2.41e-02 6.11e-02 0.2320 0.177000 0.150000 4.51e-02 8.83e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 77 2.44e-02 6.20e-02 0.1730 0.123000 0.122000 6.21e-02 6.50e-02
Removal of the Flap Intermediate 12 2.46e-02 6.22e-02 0.4570 -0.453000 0.060300 6.58e-03 7.18e-01
SCF(Skp2)-mediated degradation of p27/p21 52 2.47e-02 6.22e-02 0.2150 0.047400 0.209000 5.55e-01 9.15e-03
HCMV Early Events 50 2.47e-02 6.22e-02 0.2290 -0.201000 0.110000 1.41e-02 1.78e-01
Activation of GABAB receptors 17 2.50e-02 6.26e-02 0.3700 0.336000 0.154000 1.65e-02 2.71e-01
GABA B receptor activation 17 2.50e-02 6.26e-02 0.3700 0.336000 0.154000 1.65e-02 2.71e-01
Interleukin-10 signaling 13 2.56e-02 6.41e-02 0.4490 0.317000 -0.318000 4.77e-02 4.72e-02
Post NMDA receptor activation events 37 2.57e-02 6.41e-02 0.2660 0.174000 -0.202000 6.78e-02 3.37e-02
RHOH GTPase cycle 28 2.61e-02 6.50e-02 0.2860 0.254000 0.131000 1.99e-02 2.31e-01
Potential therapeutics for SARS 60 2.62e-02 6.50e-02 0.1940 0.128000 0.146000 8.58e-02 5.09e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 68 2.62e-02 6.50e-02 0.1960 -0.167000 0.102000 1.74e-02 1.48e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 2.63e-02 6.50e-02 0.4650 -0.371000 0.281000 2.63e-02 9.17e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 64 2.64e-02 6.52e-02 0.1890 0.101000 0.160000 1.65e-01 2.75e-02
Stimuli-sensing channels 39 2.65e-02 6.52e-02 0.2590 0.181000 -0.184000 5.03e-02 4.67e-02
Homology Directed Repair 88 2.67e-02 6.57e-02 0.1710 -0.153000 0.076200 1.33e-02 2.18e-01
Downstream signaling events of B Cell Receptor (BCR) 70 2.68e-02 6.57e-02 0.1820 0.053600 0.174000 4.39e-01 1.19e-02
Transcriptional regulation by RUNX1 133 2.69e-02 6.58e-02 0.1310 0.061200 0.116000 2.25e-01 2.11e-02
Protein folding 62 2.69e-02 6.58e-02 0.1910 0.165000 0.096400 2.46e-02 1.90e-01
ABC transporter disorders 56 2.72e-02 6.63e-02 0.2000 0.156000 0.125000 4.32e-02 1.06e-01
Collagen biosynthesis and modifying enzymes 17 2.74e-02 6.68e-02 0.3880 0.224000 -0.317000 1.10e-01 2.36e-02
Synthesis of PIPs at the plasma membrane 36 2.75e-02 6.69e-02 0.2640 0.250000 -0.083000 9.49e-03 3.89e-01
Collagen formation 27 2.76e-02 6.69e-02 0.3090 0.229000 -0.207000 3.93e-02 6.34e-02
Dual incision in TC-NER 55 2.82e-02 6.79e-02 0.2150 -0.183000 0.114000 1.94e-02 1.45e-01
Deposition of new CENPA-containing nucleosomes at the centromere 20 2.82e-02 6.79e-02 0.3470 -0.345000 0.035000 7.58e-03 7.87e-01
Nucleosome assembly 20 2.82e-02 6.79e-02 0.3470 -0.345000 0.035000 7.58e-03 7.87e-01
TCR signaling 88 2.82e-02 6.79e-02 0.1610 0.063700 0.147000 3.03e-01 1.72e-02
activated TAK1 mediates p38 MAPK activation 13 2.91e-02 6.98e-02 0.4180 0.405000 0.104000 1.15e-02 5.17e-01
Peroxisomal lipid metabolism 22 2.94e-02 7.04e-02 0.3160 0.187000 0.254000 1.28e-01 3.93e-02
Polymerase switching on the C-strand of the telomere 22 2.95e-02 7.04e-02 0.3340 -0.315000 0.110000 1.05e-02 3.70e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 56 2.97e-02 7.08e-02 0.1980 0.123000 0.155000 1.11e-01 4.55e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 52 2.99e-02 7.11e-02 0.2050 0.117000 0.169000 1.45e-01 3.57e-02
Plasma lipoprotein clearance 19 3.01e-02 7.14e-02 0.3440 0.331000 0.093700 1.27e-02 4.80e-01
Diseases of carbohydrate metabolism 22 3.04e-02 7.21e-02 0.3350 0.297000 -0.154000 1.58e-02 2.11e-01
Translesion synthesis by POLK 15 3.08e-02 7.29e-02 0.4060 -0.349000 0.207000 1.94e-02 1.65e-01
Negative regulation of FLT3 13 3.11e-02 7.34e-02 0.4130 0.125000 0.393000 4.34e-01 1.42e-02
ADORA2B mediated anti-inflammatory cytokines production 30 3.15e-02 7.41e-02 0.2740 0.272000 0.034100 9.90e-03 7.47e-01
Regulated Necrosis 42 3.16e-02 7.41e-02 0.2260 0.152000 0.168000 8.91e-02 6.05e-02
Signaling by SCF-KIT 33 3.16e-02 7.41e-02 0.2580 0.243000 0.085900 1.56e-02 3.94e-01
SUMOylation of DNA replication proteins 43 3.17e-02 7.41e-02 0.2400 -0.178000 0.161000 4.36e-02 6.80e-02
Fc epsilon receptor (FCERI) signaling 109 3.20e-02 7.46e-02 0.1410 0.119000 0.076200 3.30e-02 1.71e-01
Cell Cycle, Mitotic 417 3.20e-02 7.46e-02 0.0784 -0.044000 0.064900 1.29e-01 2.49e-02
Intraflagellar transport 31 3.21e-02 7.46e-02 0.2740 -0.272000 0.034600 8.82e-03 7.39e-01
Transcriptional Regulation by TP53 296 3.26e-02 7.56e-02 0.0897 -0.009000 0.089200 7.92e-01 8.89e-03
Vpu mediated degradation of CD4 44 3.28e-02 7.61e-02 0.2210 0.101000 0.197000 2.47e-01 2.42e-02
Nuclear Pore Complex (NPC) Disassembly 34 3.30e-02 7.64e-02 0.2670 -0.231000 0.133000 1.98e-02 1.79e-01
Late endosomal microautophagy 23 3.33e-02 7.69e-02 0.3110 0.308000 0.039300 1.06e-02 7.44e-01
RAF activation 28 3.36e-02 7.74e-02 0.2820 0.280000 0.029700 1.03e-02 7.86e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 24 3.37e-02 7.75e-02 0.3180 -0.246000 0.201000 3.68e-02 8.86e-02
Negative regulation of MET activity 16 3.38e-02 7.75e-02 0.3690 0.357000 0.093100 1.36e-02 5.19e-01
Activation of NF-kappaB in B cells 57 3.50e-02 8.02e-02 0.1920 0.107000 0.159000 1.65e-01 3.76e-02
Interleukin-6 family signaling 12 3.61e-02 8.25e-02 0.4170 0.379000 0.176000 2.32e-02 2.92e-01
Mismatch Repair 13 3.64e-02 8.29e-02 0.4270 -0.334000 0.266000 3.73e-02 9.68e-02
RNA Polymerase I Promoter Escape 24 3.64e-02 8.29e-02 0.3110 -0.288000 0.116000 1.45e-02 3.26e-01
Activation of kainate receptors upon glutamate binding 16 3.69e-02 8.38e-02 0.3580 0.265000 0.240000 6.70e-02 9.61e-02
Response of Mtb to phagocytosis 20 3.84e-02 8.71e-02 0.3220 0.305000 0.102000 1.81e-02 4.29e-01
Signaling by EGFR 36 3.87e-02 8.75e-02 0.2460 0.246000 -0.009480 1.08e-02 9.22e-01
G2/M Checkpoints 116 3.94e-02 8.89e-02 0.1420 -0.075900 0.119000 1.59e-01 2.68e-02
Downstream TCR signaling 72 3.95e-02 8.90e-02 0.1700 0.048200 0.163000 4.81e-01 1.71e-02
CLEC7A (Dectin-1) signaling 84 3.98e-02 8.95e-02 0.1550 0.119000 0.099100 6.01e-02 1.17e-01
Antigen processing: Ubiquitination & Proteasome degradation 236 3.99e-02 8.95e-02 0.0931 0.071400 0.059800 6.07e-02 1.17e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 21 3.99e-02 8.95e-02 0.3160 0.314000 0.040700 1.29e-02 7.47e-01
G alpha (s) signalling events 38 4.07e-02 9.08e-02 0.2330 0.228000 0.050600 1.52e-02 5.90e-01
Chaperonin-mediated protein folding 56 4.08e-02 9.08e-02 0.1900 0.172000 0.080600 2.62e-02 2.98e-01
Diseases associated with the TLR signaling cascade 16 4.09e-02 9.08e-02 0.3600 0.354000 0.062400 1.41e-02 6.66e-01
Diseases of Immune System 16 4.09e-02 9.08e-02 0.3600 0.354000 0.062400 1.41e-02 6.66e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 25 4.10e-02 9.08e-02 0.2860 0.272000 0.086200 1.85e-02 4.56e-01
Sema3A PAK dependent Axon repulsion 11 4.10e-02 9.08e-02 0.4560 0.304000 -0.340000 8.11e-02 5.12e-02
Signaling by Leptin 10 4.11e-02 9.08e-02 0.4460 0.373000 0.244000 4.12e-02 1.81e-01
Biological oxidations 77 4.21e-02 9.30e-02 0.1650 -0.006520 -0.165000 9.21e-01 1.24e-02
Cytoprotection by HMOX1 94 4.25e-02 9.34e-02 0.1460 0.128000 0.069400 3.24e-02 2.46e-01
RNA Polymerase I Transcription Termination 23 4.25e-02 9.34e-02 0.3110 -0.279000 0.137000 2.05e-02 2.56e-01
PI Metabolism 59 4.26e-02 9.34e-02 0.1910 0.189000 -0.024800 1.21e-02 7.42e-01
Cell Cycle Checkpoints 222 4.30e-02 9.42e-02 0.1020 -0.069400 0.074600 7.69e-02 5.72e-02
Metabolism of proteins 1261 4.32e-02 9.45e-02 0.0424 0.020600 0.037100 2.40e-01 3.38e-02
Interleukin-6 signaling 10 4.34e-02 9.47e-02 0.4410 0.338000 0.284000 6.46e-02 1.20e-01
APC/C:Cdc20 mediated degradation of Securin 58 4.35e-02 9.47e-02 0.1850 0.076800 0.168000 3.12e-01 2.70e-02
Activation of HOX genes during differentiation 38 4.36e-02 9.47e-02 0.2300 0.057300 0.223000 5.42e-01 1.75e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 38 4.36e-02 9.47e-02 0.2300 0.057300 0.223000 5.42e-01 1.75e-02
Infection with Mycobacterium tuberculosis 22 4.40e-02 9.54e-02 0.3020 0.290000 0.081600 1.85e-02 5.08e-01
Carboxyterminal post-translational modifications of tubulin 22 4.42e-02 9.56e-02 0.3020 0.296000 0.063800 1.64e-02 6.05e-01
Nucleotide Excision Repair 98 4.43e-02 9.57e-02 0.1510 -0.127000 0.082300 3.08e-02 1.60e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 10 4.45e-02 9.60e-02 0.4720 0.360000 -0.304000 4.85e-02 9.58e-02
Synthesis of PC 19 4.52e-02 9.72e-02 0.3200 0.281000 0.153000 3.42e-02 2.50e-01
Oncogene Induced Senescence 30 4.58e-02 9.81e-02 0.2530 0.208000 0.144000 4.87e-02 1.73e-01
DNA Damage Bypass 41 4.58e-02 9.81e-02 0.2320 -0.188000 0.136000 3.75e-02 1.33e-01
B-WICH complex positively regulates rRNA expression 24 4.60e-02 9.83e-02 0.3030 -0.241000 0.184000 4.15e-02 1.19e-01
Removal of the Flap Intermediate from the C-strand 15 4.66e-02 9.95e-02 0.3820 -0.282000 0.258000 5.86e-02 8.35e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 18 4.87e-02 1.04e-01 0.3420 -0.123000 0.319000 3.65e-01 1.90e-02
FOXO-mediated transcription of cell death genes 14 4.89e-02 1.04e-01 0.3780 0.378000 -0.001800 1.42e-02 9.91e-01
Cellular Senescence 105 4.90e-02 1.04e-01 0.1350 0.123000 0.055900 2.98e-02 3.24e-01
Activation of G protein gated Potassium channels 11 4.93e-02 1.04e-01 0.4120 0.281000 0.301000 1.07e-01 8.42e-02
G protein gated Potassium channels 11 4.93e-02 1.04e-01 0.4120 0.281000 0.301000 1.07e-01 8.42e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 11 4.93e-02 1.04e-01 0.4120 0.281000 0.301000 1.07e-01 8.42e-02
Chromatin modifying enzymes 150 5.01e-02 1.05e-01 0.1170 -0.015800 0.116000 7.40e-01 1.46e-02
Chromatin organization 150 5.01e-02 1.05e-01 0.1170 -0.015800 0.116000 7.40e-01 1.46e-02
Pre-NOTCH Transcription and Translation 27 5.01e-02 1.05e-01 0.2650 0.245000 0.101000 2.76e-02 3.66e-01
RNA Polymerase III Chain Elongation 16 5.13e-02 1.07e-01 0.3630 -0.314000 0.182000 2.98e-02 2.09e-01
ABC-family proteins mediated transport 72 5.15e-02 1.08e-01 0.1600 0.098400 0.127000 1.50e-01 6.37e-02
Mitotic G2-G2/M phases 156 5.17e-02 1.08e-01 0.1100 0.057000 0.093700 2.21e-01 4.44e-02
Axon guidance 293 5.27e-02 1.10e-01 0.0811 0.027400 0.076300 4.25e-01 2.59e-02
Autodegradation of Cdh1 by Cdh1:APC/C 56 5.36e-02 1.12e-01 0.1820 0.071400 0.167000 3.56e-01 3.05e-02
Costimulation by the CD28 family 45 5.39e-02 1.12e-01 0.2050 0.049100 0.199000 5.70e-01 2.14e-02
mTORC1-mediated signalling 22 5.55e-02 1.15e-01 0.2870 0.255000 0.132000 3.83e-02 2.86e-01
Interleukin-20 family signaling 13 5.63e-02 1.17e-01 0.3710 0.292000 0.228000 6.81e-02 1.55e-01
Dectin-1 mediated noncanonical NF-kB signaling 52 5.68e-02 1.17e-01 0.1860 0.105000 0.153000 1.93e-01 5.61e-02
Generation of second messenger molecules 16 5.71e-02 1.18e-01 0.3550 -0.323000 0.146000 2.54e-02 3.11e-01
HDACs deacetylate histones 28 5.74e-02 1.18e-01 0.2520 0.167000 0.188000 1.27e-01 8.46e-02
Signaling by TGFB family members 73 5.77e-02 1.19e-01 0.1580 0.150000 0.051000 2.73e-02 4.52e-01
Amyloid fiber formation 24 5.80e-02 1.19e-01 0.2750 0.260000 0.087900 2.73e-02 4.56e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 22 5.84e-02 1.20e-01 0.2830 0.168000 0.228000 1.72e-01 6.45e-02
Regulation of TP53 Activity 131 5.92e-02 1.21e-01 0.1250 -0.085000 0.091700 9.42e-02 7.10e-02
Sphingolipid de novo biosynthesis 23 5.93e-02 1.21e-01 0.2950 0.254000 -0.151000 3.51e-02 2.11e-01
ERKs are inactivated 12 5.95e-02 1.21e-01 0.3980 0.396000 -0.043700 1.76e-02 7.93e-01
NOTCH1 Intracellular Domain Regulates Transcription 36 6.01e-02 1.22e-01 0.2210 0.181000 0.127000 6.12e-02 1.88e-01
Global Genome Nucleotide Excision Repair (GG-NER) 76 6.04e-02 1.22e-01 0.1620 -0.144000 0.074600 3.06e-02 2.62e-01
Iron uptake and transport 38 6.04e-02 1.22e-01 0.2280 0.207000 -0.096300 2.75e-02 3.05e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 14 6.06e-02 1.23e-01 0.3710 0.360000 -0.087800 1.96e-02 5.70e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 6.17e-02 1.24e-01 0.4060 -0.342000 0.220000 4.04e-02 1.88e-01
Intra-Golgi traffic 39 6.18e-02 1.24e-01 0.2200 0.218000 -0.032100 1.86e-02 7.29e-01
MAPK targets/ Nuclear events mediated by MAP kinases 24 6.26e-02 1.26e-01 0.2820 0.274000 -0.063900 2.01e-02 5.88e-01
G2/M Transition 154 6.27e-02 1.26e-01 0.1070 0.049400 0.094900 2.92e-01 4.31e-02
Signaling by FGFR1 in disease 25 6.29e-02 1.26e-01 0.2810 0.170000 -0.224000 1.40e-01 5.30e-02
Interleukin receptor SHC signaling 16 6.31e-02 1.26e-01 0.3270 0.232000 0.231000 1.09e-01 1.10e-01
NIK–>noncanonical NF-kB signaling 51 6.35e-02 1.27e-01 0.1840 0.107000 0.149000 1.87e-01 6.57e-02
Spry regulation of FGF signaling 15 6.36e-02 1.27e-01 0.3520 0.350000 -0.043100 1.91e-02 7.73e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) 32 6.38e-02 1.27e-01 0.2370 0.234000 0.037600 2.23e-02 7.13e-01
SCF-beta-TrCP mediated degradation of Emi1 47 6.40e-02 1.27e-01 0.1920 0.082000 0.174000 3.31e-01 3.96e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 10 6.45e-02 1.28e-01 0.4130 0.241000 0.335000 1.88e-01 6.65e-02
SUMOylation of intracellular receptors 18 6.56e-02 1.30e-01 0.3070 0.164000 0.260000 2.28e-01 5.66e-02
FGFR1 mutant receptor activation 20 6.58e-02 1.30e-01 0.3100 0.276000 -0.141000 3.28e-02 2.74e-01
Cholesterol biosynthesis 20 6.64e-02 1.31e-01 0.3070 0.291000 -0.099300 2.46e-02 4.42e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 82 6.66e-02 1.31e-01 0.1530 -0.135000 0.073600 3.56e-02 2.50e-01
Vasopressin regulates renal water homeostasis via Aquaporins 21 6.67e-02 1.31e-01 0.2890 0.285000 0.051100 2.41e-02 6.85e-01
mRNA decay by 3’ to 5’ exoribonuclease 14 6.68e-02 1.31e-01 0.3470 -0.299000 -0.177000 5.28e-02 2.52e-01
Myogenesis 13 6.69e-02 1.31e-01 0.3770 0.370000 -0.073300 2.10e-02 6.47e-01
RNA Polymerase III Transcription Initiation 33 6.74e-02 1.32e-01 0.2420 -0.176000 0.167000 8.10e-02 9.80e-02
Deadenylation of mRNA 21 6.87e-02 1.34e-01 0.2970 -0.080100 0.286000 5.25e-01 2.35e-02
Interleukin-37 signaling 17 6.92e-02 1.35e-01 0.3120 0.248000 0.190000 7.69e-02 1.75e-01
MET promotes cell motility 13 6.98e-02 1.36e-01 0.3560 0.234000 0.268000 1.44e-01 9.39e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 10 7.06e-02 1.37e-01 0.4340 0.235000 -0.365000 1.99e-01 4.56e-02
Translesion Synthesis by POLH 16 7.14e-02 1.37e-01 0.3440 -0.249000 0.237000 8.51e-02 1.01e-01
S33 mutants of beta-catenin aren’t phosphorylated 13 7.14e-02 1.37e-01 0.3620 0.356000 0.069400 2.65e-02 6.65e-01
S37 mutants of beta-catenin aren’t phosphorylated 13 7.14e-02 1.37e-01 0.3620 0.356000 0.069400 2.65e-02 6.65e-01
S45 mutants of beta-catenin aren’t phosphorylated 13 7.14e-02 1.37e-01 0.3620 0.356000 0.069400 2.65e-02 6.65e-01
Signaling by CTNNB1 phospho-site mutants 13 7.14e-02 1.37e-01 0.3620 0.356000 0.069400 2.65e-02 6.65e-01
Signaling by GSK3beta mutants 13 7.14e-02 1.37e-01 0.3620 0.356000 0.069400 2.65e-02 6.65e-01
T41 mutants of beta-catenin aren’t phosphorylated 13 7.14e-02 1.37e-01 0.3620 0.356000 0.069400 2.65e-02 6.65e-01
Signaling by Non-Receptor Tyrosine Kinases 33 7.24e-02 1.39e-01 0.2260 0.216000 0.065800 3.21e-02 5.13e-01
Signaling by PTK6 33 7.24e-02 1.39e-01 0.2260 0.216000 0.065800 3.21e-02 5.13e-01
Cyclin A:Cdk2-associated events at S phase entry 74 7.43e-02 1.42e-01 0.1520 0.014800 0.151000 8.26e-01 2.46e-02
Peroxisomal protein import 48 7.49e-02 1.43e-01 0.1840 0.165000 0.082000 4.79e-02 3.27e-01
Retinoid metabolism and transport 10 7.50e-02 1.43e-01 0.4050 0.379000 0.142000 3.79e-02 4.36e-01
Gastrin-CREB signalling pathway via PKC and MAPK 12 7.53e-02 1.43e-01 0.3900 0.348000 -0.175000 3.67e-02 2.94e-01
Activation of NMDA receptors and postsynaptic events 42 7.54e-02 1.43e-01 0.2100 0.130000 -0.165000 1.46e-01 6.46e-02
TP53 Regulates Metabolic Genes 72 7.58e-02 1.44e-01 0.1540 0.153000 0.012700 2.48e-02 8.52e-01
Regulation of IFNA signaling 12 7.58e-02 1.44e-01 0.3690 0.345000 0.130000 3.83e-02 4.36e-01
Leading Strand Synthesis 12 7.69e-02 1.45e-01 0.3800 -0.377000 0.046500 2.37e-02 7.81e-01
Polymerase switching 12 7.69e-02 1.45e-01 0.3800 -0.377000 0.046500 2.37e-02 7.81e-01
HDR through Single Strand Annealing (SSA) 34 7.70e-02 1.45e-01 0.2260 -0.224000 0.034200 2.40e-02 7.30e-01
Metabolism of steroid hormones 12 7.73e-02 1.45e-01 0.3630 0.261000 0.253000 1.18e-01 1.30e-01
Sensory processing of sound by outer hair cells of the cochlea 16 7.73e-02 1.45e-01 0.3300 -0.057500 0.325000 6.91e-01 2.44e-02
PIWI-interacting RNA (piRNA) biogenesis 15 7.73e-02 1.45e-01 0.3490 -0.221000 0.270000 1.38e-01 7.00e-02
Amino acid transport across the plasma membrane 16 7.78e-02 1.46e-01 0.3330 0.105000 -0.316000 4.67e-01 2.88e-02
Ub-specific processing proteases 131 7.81e-02 1.46e-01 0.1110 0.058300 0.094300 2.51e-01 6.34e-02
Adrenaline,noradrenaline inhibits insulin secretion 14 7.85e-02 1.46e-01 0.3360 0.234000 0.240000 1.29e-01 1.20e-01
Regulation of TP53 Activity through Acetylation 26 7.86e-02 1.47e-01 0.2600 -0.075900 0.249000 5.03e-01 2.81e-02
Condensation of Prophase Chromosomes 11 7.88e-02 1.47e-01 0.3780 -0.296000 -0.235000 8.87e-02 1.77e-01
Synthesis of very long-chain fatty acyl-CoAs 16 8.13e-02 1.51e-01 0.3230 -0.006260 0.323000 9.65e-01 2.53e-02
Regulation of MECP2 expression and activity 23 8.45e-02 1.57e-01 0.2600 0.111000 0.235000 3.58e-01 5.09e-02
Signaling by Nuclear Receptors 147 8.48e-02 1.57e-01 0.1030 0.074900 0.070300 1.19e-01 1.43e-01
RET signaling 22 8.50e-02 1.57e-01 0.2710 0.270000 0.027200 2.87e-02 8.25e-01
Transcriptional regulation of granulopoiesis 24 8.65e-02 1.60e-01 0.2660 0.253000 -0.084500 3.23e-02 4.74e-01
Role of LAT2/NTAL/LAB on calcium mobilization 11 8.70e-02 1.60e-01 0.3910 0.378000 -0.099400 3.00e-02 5.68e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 63 8.79e-02 1.62e-01 0.1580 0.040100 0.153000 5.82e-01 3.66e-02
Apoptotic execution phase 33 8.79e-02 1.62e-01 0.2280 0.204000 -0.102000 4.28e-02 3.10e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 8.82e-02 1.62e-01 0.3190 0.288000 0.138000 5.38e-02 3.55e-01
DARPP-32 events 20 8.86e-02 1.62e-01 0.2900 0.275000 -0.091800 3.32e-02 4.78e-01
InlB-mediated entry of Listeria monocytogenes into host cell 11 8.99e-02 1.64e-01 0.3710 0.330000 0.170000 5.85e-02 3.30e-01
Interleukin-2 family signaling 29 9.01e-02 1.64e-01 0.2280 0.191000 0.123000 7.50e-02 2.50e-01
Factors involved in megakaryocyte development and platelet production 86 9.04e-02 1.65e-01 0.1380 0.137000 -0.010800 2.84e-02 8.63e-01
Nuclear Envelope Breakdown 49 9.34e-02 1.70e-01 0.1860 -0.116000 0.146000 1.62e-01 7.75e-02
Cyclin E associated events during G1/S transition 72 9.34e-02 1.70e-01 0.1470 0.024600 0.145000 7.19e-01 3.44e-02
HATs acetylate histones 58 9.61e-02 1.74e-01 0.1700 -0.136000 0.102000 7.28e-02 1.81e-01
LDL clearance 13 9.96e-02 1.80e-01 0.3360 0.317000 0.111000 4.79e-02 4.90e-01
Negative epigenetic regulation of rRNA expression 40 1.00e-01 1.81e-01 0.2030 -0.145000 0.142000 1.12e-01 1.20e-01
SUMOylation of immune response proteins 10 1.00e-01 1.81e-01 0.3780 0.232000 0.299000 2.05e-01 1.02e-01
Insulin processing 17 1.00e-01 1.81e-01 0.2900 0.201000 0.208000 1.51e-01 1.38e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 62 1.01e-01 1.83e-01 0.1540 0.035600 0.150000 6.29e-01 4.10e-02
Metabolism of polyamines 48 1.04e-01 1.87e-01 0.1720 0.088100 0.148000 2.92e-01 7.71e-02
Synthesis of PIPs at the early endosome membrane 12 1.04e-01 1.87e-01 0.3420 0.250000 0.233000 1.34e-01 1.63e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 34 1.05e-01 1.87e-01 0.2180 -0.162000 0.146000 1.02e-01 1.41e-01
Gluconeogenesis 24 1.05e-01 1.88e-01 0.2560 0.238000 -0.094200 4.33e-02 4.25e-01
Early Phase of HIV Life Cycle 13 1.05e-01 1.88e-01 0.3450 -0.334000 0.088200 3.72e-02 5.82e-01
M Phase 291 1.07e-01 1.91e-01 0.0712 0.019300 0.068500 5.75e-01 4.64e-02
Sialic acid metabolism 23 1.08e-01 1.92e-01 0.2590 0.246000 -0.081300 4.12e-02 5.00e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 66 1.08e-01 1.92e-01 0.1470 0.049200 0.138000 4.91e-01 5.26e-02
G1/S-Specific Transcription 25 1.10e-01 1.95e-01 0.2490 -0.227000 0.103000 4.97e-02 3.73e-01
Apoptotic cleavage of cellular proteins 25 1.10e-01 1.95e-01 0.2480 0.234000 -0.083100 4.34e-02 4.72e-01
Transcriptional Regulation by MECP2 31 1.13e-01 1.99e-01 0.2090 0.153000 0.142000 1.40e-01 1.70e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 1.13e-01 1.99e-01 0.3600 0.358000 0.038100 3.97e-02 8.27e-01
NOD1/2 Signaling Pathway 23 1.13e-01 2.00e-01 0.2420 0.147000 0.193000 2.22e-01 1.10e-01
Constitutive Signaling by AKT1 E17K in Cancer 23 1.14e-01 2.01e-01 0.2470 0.240000 0.055300 4.61e-02 6.46e-01
Inactivation of CSF3 (G-CSF) signaling 19 1.14e-01 2.01e-01 0.2710 0.263000 0.067000 4.77e-02 6.13e-01
Glucagon-type ligand receptors 13 1.14e-01 2.01e-01 0.3230 0.166000 0.277000 2.99e-01 8.44e-02
NR1H2 and NR1H3-mediated signaling 26 1.16e-01 2.04e-01 0.2270 0.147000 0.173000 1.96e-01 1.28e-01
Platelet calcium homeostasis 16 1.19e-01 2.08e-01 0.3090 0.233000 -0.202000 1.07e-01 1.61e-01
FCGR3A-mediated IL10 synthesis 22 1.19e-01 2.08e-01 0.2610 0.114000 -0.235000 3.55e-01 5.66e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 14 1.20e-01 2.10e-01 0.3280 -0.181000 0.274000 2.42e-01 7.60e-02
Aquaporin-mediated transport 22 1.21e-01 2.11e-01 0.2510 0.249000 0.030100 4.36e-02 8.07e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 16 1.21e-01 2.11e-01 0.2860 0.223000 0.179000 1.23e-01 2.14e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 65 1.21e-01 2.11e-01 0.1440 0.043900 0.137000 5.41e-01 5.59e-02
Signaling by NOTCH2 18 1.22e-01 2.11e-01 0.2760 0.272000 0.044700 4.58e-02 7.43e-01
Deadenylation-dependent mRNA decay 50 1.23e-01 2.14e-01 0.1710 -0.161000 0.059200 4.99e-02 4.70e-01
RNA polymerase II transcribes snRNA genes 63 1.26e-01 2.18e-01 0.1440 0.069600 0.126000 3.40e-01 8.48e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter 25 1.26e-01 2.18e-01 0.2440 -0.174000 0.171000 1.33e-01 1.39e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 38 1.27e-01 2.19e-01 0.1840 0.135000 0.125000 1.52e-01 1.82e-01
Processing of DNA double-strand break ends 54 1.27e-01 2.19e-01 0.1640 -0.149000 0.068400 5.81e-02 3.86e-01
Oxidative Stress Induced Senescence 54 1.33e-01 2.28e-01 0.1550 0.146000 0.049700 6.33e-02 5.29e-01
Ion transport by P-type ATPases 27 1.34e-01 2.31e-01 0.2300 0.193000 -0.126000 8.36e-02 2.57e-01
Signaling by cytosolic FGFR1 fusion mutants 17 1.35e-01 2.32e-01 0.2860 0.269000 -0.098700 5.51e-02 4.81e-01
mRNA Splicing - Minor Pathway 44 1.35e-01 2.32e-01 0.1790 -0.159000 0.083700 6.88e-02 3.37e-01
Keratan sulfate/keratin metabolism 19 1.36e-01 2.32e-01 0.2580 0.240000 0.094700 7.02e-02 4.75e-01
FCERI mediated NF-kB activation 64 1.36e-01 2.32e-01 0.1400 0.075000 0.118000 3.01e-01 1.03e-01
RHOD GTPase cycle 37 1.36e-01 2.32e-01 0.1830 0.139000 0.119000 1.43e-01 2.11e-01
Retrograde transport at the Trans-Golgi-Network 45 1.37e-01 2.32e-01 0.1760 0.164000 -0.064500 5.75e-02 4.55e-01
GAB1 signalosome 10 1.39e-01 2.36e-01 0.3540 0.330000 0.126000 7.06e-02 4.90e-01
PINK1-PRKN Mediated Mitophagy 18 1.42e-01 2.41e-01 0.2590 -0.203000 -0.162000 1.36e-01 2.35e-01
Fatty acid metabolism 102 1.43e-01 2.42e-01 0.1120 0.111000 0.016500 5.41e-02 7.74e-01
Hedgehog ‘off’ state 75 1.46e-01 2.47e-01 0.1270 0.070500 0.105000 2.92e-01 1.16e-01
Cardiac conduction 40 1.46e-01 2.47e-01 0.1830 0.065400 -0.171000 4.75e-01 6.11e-02
NOTCH4 Intracellular Domain Regulates Transcription 13 1.47e-01 2.49e-01 0.3070 0.293000 0.091200 6.78e-02 5.69e-01
Cytosolic sensors of pathogen-associated DNA 51 1.49e-01 2.51e-01 0.1570 0.013400 0.156000 8.68e-01 5.40e-02
RUNX2 regulates bone development 16 1.49e-01 2.51e-01 0.2790 0.278000 0.025500 5.43e-02 8.60e-01
E3 ubiquitin ligases ubiquitinate target proteins 41 1.51e-01 2.52e-01 0.1690 0.127000 0.112000 1.61e-01 2.14e-01
Deactivation of the beta-catenin transactivating complex 28 1.51e-01 2.52e-01 0.2060 0.099500 0.180000 3.63e-01 9.93e-02
APC truncation mutants have impaired AXIN binding 12 1.52e-01 2.52e-01 0.3210 0.319000 0.031500 5.56e-02 8.50e-01
AXIN missense mutants destabilize the destruction complex 12 1.52e-01 2.52e-01 0.3210 0.319000 0.031500 5.56e-02 8.50e-01
Signaling by AMER1 mutants 12 1.52e-01 2.52e-01 0.3210 0.319000 0.031500 5.56e-02 8.50e-01
Signaling by APC mutants 12 1.52e-01 2.52e-01 0.3210 0.319000 0.031500 5.56e-02 8.50e-01
Signaling by AXIN mutants 12 1.52e-01 2.52e-01 0.3210 0.319000 0.031500 5.56e-02 8.50e-01
Truncations of AMER1 destabilize the destruction complex 12 1.52e-01 2.52e-01 0.3210 0.319000 0.031500 5.56e-02 8.50e-01
Antiviral mechanism by IFN-stimulated genes 77 1.52e-01 2.52e-01 0.1320 -0.120000 0.054800 7.01e-02 4.07e-01
Negative regulation of FGFR1 signaling 17 1.57e-01 2.59e-01 0.2760 0.256000 -0.104000 6.80e-02 4.60e-01
Negative regulation of FGFR2 signaling 17 1.57e-01 2.59e-01 0.2760 0.256000 -0.104000 6.80e-02 4.60e-01
Negative regulation of FGFR3 signaling 17 1.57e-01 2.59e-01 0.2760 0.256000 -0.104000 6.80e-02 4.60e-01
Negative regulation of FGFR4 signaling 17 1.57e-01 2.59e-01 0.2760 0.256000 -0.104000 6.80e-02 4.60e-01
RUNX3 regulates NOTCH signaling 11 1.58e-01 2.60e-01 0.3240 0.281000 0.161000 1.07e-01 3.55e-01
Signaling by FLT3 ITD and TKD mutants 13 1.60e-01 2.64e-01 0.3090 0.306000 -0.035300 5.58e-02 8.26e-01
Disorders of transmembrane transporters 105 1.61e-01 2.65e-01 0.1060 0.031700 0.101000 5.76e-01 7.46e-02
Cilium Assembly 147 1.61e-01 2.65e-01 0.0938 -0.087300 0.034500 6.90e-02 4.73e-01
Listeria monocytogenes entry into host cells 14 1.62e-01 2.66e-01 0.2910 0.288000 0.040200 6.21e-02 7.95e-01
NGF-stimulated transcription 25 1.64e-01 2.69e-01 0.2170 0.213000 0.037400 6.50e-02 7.46e-01
Triglyceride catabolism 11 1.64e-01 2.69e-01 0.3370 0.322000 -0.099400 6.44e-02 5.68e-01
TP53 Regulates Transcription of DNA Repair Genes 51 1.65e-01 2.70e-01 0.1590 -0.110000 0.116000 1.76e-01 1.54e-01
Pyroptosis 18 1.66e-01 2.71e-01 0.2490 0.134000 0.210000 3.25e-01 1.23e-01
Cell recruitment (pro-inflammatory response) 15 1.66e-01 2.71e-01 0.2910 0.250000 -0.150000 9.43e-02 3.15e-01
Purinergic signaling in leishmaniasis infection 15 1.66e-01 2.71e-01 0.2910 0.250000 -0.150000 9.43e-02 3.15e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 15 1.68e-01 2.73e-01 0.2910 0.248000 -0.151000 9.64e-02 3.10e-01
Nucleobase catabolism 21 1.69e-01 2.74e-01 0.2350 0.234000 0.028300 6.41e-02 8.23e-01
Mitotic Anaphase 193 1.70e-01 2.75e-01 0.0772 0.024800 0.073100 5.56e-01 8.16e-02
NoRC negatively regulates rRNA expression 39 1.70e-01 2.75e-01 0.1810 -0.131000 0.124000 1.57e-01 1.80e-01
Protein localization 122 1.70e-01 2.75e-01 0.1020 -0.052100 0.087700 3.22e-01 9.55e-02
Calnexin/calreticulin cycle 23 1.71e-01 2.76e-01 0.2220 0.215000 0.054300 7.40e-02 6.52e-01
mRNA 3’-end processing 35 1.71e-01 2.76e-01 0.1860 -0.046000 0.181000 6.38e-01 6.45e-02
ISG15 antiviral mechanism 70 1.72e-01 2.77e-01 0.1320 -0.128000 0.033500 6.54e-02 6.29e-01
Transcriptional Regulation by E2F6 29 1.73e-01 2.77e-01 0.1980 -0.192000 -0.045500 7.34e-02 6.72e-01
ZBP1(DAI) mediated induction of type I IFNs 17 1.73e-01 2.78e-01 0.2530 0.203000 0.151000 1.48e-01 2.80e-01
RIPK1-mediated regulated necrosis 24 1.74e-01 2.78e-01 0.2130 0.164000 0.135000 1.63e-01 2.52e-01
Regulation of necroptotic cell death 24 1.74e-01 2.78e-01 0.2130 0.164000 0.135000 1.63e-01 2.52e-01
Fatty acyl-CoA biosynthesis 26 1.78e-01 2.84e-01 0.2070 0.047700 0.201000 6.74e-01 7.60e-02
Signaling by Hedgehog 97 1.78e-01 2.84e-01 0.1070 0.102000 0.032000 8.31e-02 5.88e-01
Mitophagy 23 1.78e-01 2.84e-01 0.2160 -0.122000 -0.178000 3.10e-01 1.40e-01
Cell-cell junction organization 12 1.79e-01 2.84e-01 0.3030 -0.075900 -0.294000 6.49e-01 7.81e-02
Regulation of beta-cell development 14 1.79e-01 2.85e-01 0.2820 0.276000 0.055300 7.38e-02 7.20e-01
Glycogen metabolism 17 1.80e-01 2.85e-01 0.2660 0.245000 -0.103000 8.03e-02 4.62e-01
Telomere C-strand synthesis initiation 10 1.80e-01 2.85e-01 0.3460 -0.321000 0.131000 7.94e-02 4.72e-01
RNA Polymerase III Abortive And Retractive Initiation 37 1.82e-01 2.88e-01 0.1820 -0.142000 0.113000 1.36e-01 2.33e-01
RNA Polymerase III Transcription 37 1.82e-01 2.88e-01 0.1820 -0.142000 0.113000 1.36e-01 2.33e-01
Mitotic Metaphase and Anaphase 194 1.83e-01 2.89e-01 0.0756 0.019900 0.073000 6.35e-01 8.16e-02
PKMTs methylate histone lysines 30 1.85e-01 2.92e-01 0.1930 -0.001580 0.193000 9.88e-01 6.69e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation 14 1.87e-01 2.94e-01 0.2900 0.122000 -0.263000 4.31e-01 8.82e-02
NOTCH3 Intracellular Domain Regulates Transcription 14 1.88e-01 2.95e-01 0.2810 0.280000 0.014300 6.95e-02 9.26e-01
Phase II - Conjugation of compounds 44 1.88e-01 2.95e-01 0.1590 0.003110 -0.159000 9.72e-01 6.79e-02
Inwardly rectifying K+ channels 12 1.93e-01 3.03e-01 0.2910 0.208000 0.203000 2.11e-01 2.23e-01
Metabolism of fat-soluble vitamins 12 1.94e-01 3.04e-01 0.2920 0.256000 0.141000 1.25e-01 3.98e-01
Organelle biogenesis and maintenance 197 1.97e-01 3.07e-01 0.0754 -0.074900 0.008720 7.15e-02 8.34e-01
Signaling by Retinoic Acid 17 1.97e-01 3.07e-01 0.2460 -0.092400 -0.228000 5.10e-01 1.04e-01
RUNX3 regulates p14-ARF 10 1.97e-01 3.07e-01 0.3180 0.257000 0.187000 1.59e-01 3.07e-01
Insulin receptor signalling cascade 26 1.97e-01 3.07e-01 0.1970 0.143000 0.135000 2.07e-01 2.33e-01
RNA Polymerase III Transcription Termination 20 1.98e-01 3.07e-01 0.2380 -0.224000 0.080500 8.36e-02 5.34e-01
ECM proteoglycans 12 2.02e-01 3.14e-01 0.2950 -0.040700 -0.292000 8.07e-01 8.03e-02
Diseases associated with glycosaminoglycan metabolism 15 2.02e-01 3.14e-01 0.2600 0.086400 0.245000 5.63e-01 1.00e-01
Activation of BAD and translocation to mitochondria 14 2.04e-01 3.15e-01 0.2730 0.272000 0.024000 7.81e-02 8.76e-01
Negative regulation of MAPK pathway 36 2.04e-01 3.15e-01 0.1670 0.154000 0.064300 1.09e-01 5.05e-01
Signaling by WNT in cancer 22 2.08e-01 3.21e-01 0.2160 0.214000 0.030200 8.31e-02 8.06e-01
Regulation of PTEN gene transcription 49 2.08e-01 3.21e-01 0.1410 0.102000 0.097400 2.17e-01 2.39e-01
Signaling by FGFR3 26 2.09e-01 3.22e-01 0.2070 0.176000 -0.109000 1.21e-01 3.34e-01
VEGFR2 mediated vascular permeability 22 2.14e-01 3.29e-01 0.2110 0.195000 0.080000 1.14e-01 5.16e-01
Suppression of phagosomal maturation 12 2.14e-01 3.29e-01 0.2860 0.271000 0.091000 1.04e-01 5.85e-01
RIP-mediated NFkB activation via ZBP1 14 2.17e-01 3.32e-01 0.2610 0.212000 0.152000 1.70e-01 3.25e-01
Defects in vitamin and cofactor metabolism 16 2.22e-01 3.40e-01 0.2570 -0.238000 0.096500 9.97e-02 5.04e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 2.22e-01 3.40e-01 0.1750 0.172000 0.032200 9.34e-02 7.53e-01
Regulation of TP53 Activity through Methylation 17 2.23e-01 3.40e-01 0.2510 -0.192000 0.162000 1.70e-01 2.48e-01
HDMs demethylate histones 13 2.24e-01 3.41e-01 0.2870 0.229000 -0.173000 1.53e-01 2.82e-01
Diseases associated with N-glycosylation of proteins 15 2.26e-01 3.45e-01 0.2560 0.009530 0.256000 9.49e-01 8.67e-02
Interleukin-15 signaling 12 2.27e-01 3.45e-01 0.2910 0.283000 -0.067200 8.92e-02 6.87e-01
Selective autophagy 48 2.28e-01 3.46e-01 0.1470 0.048600 -0.138000 5.60e-01 9.75e-02
Interleukin-7 signaling 14 2.28e-01 3.46e-01 0.2570 0.125000 0.225000 4.17e-01 1.46e-01
Signaling by PDGF 25 2.32e-01 3.51e-01 0.1940 0.189000 0.044400 1.02e-01 7.01e-01
Depolymerisation of the Nuclear Lamina 13 2.32e-01 3.51e-01 0.2650 0.227000 0.136000 1.56e-01 3.96e-01
Formation of TC-NER Pre-Incision Complex 45 2.32e-01 3.51e-01 0.1530 -0.101000 0.115000 2.42e-01 1.84e-01
Estrogen-dependent gene expression 68 2.32e-01 3.51e-01 0.1190 0.011400 0.118000 8.71e-01 9.21e-02
Meiotic recombination 16 2.33e-01 3.52e-01 0.2470 -0.246000 0.016300 8.80e-02 9.10e-01
RAF-independent MAPK1/3 activation 20 2.36e-01 3.55e-01 0.2120 0.128000 0.169000 3.21e-01 1.92e-01
HCMV Late Events 51 2.37e-01 3.56e-01 0.1390 -0.023200 0.137000 7.74e-01 9.12e-02
Diseases associated with glycosylation precursor biosynthesis 18 2.42e-01 3.64e-01 0.2310 0.229000 -0.028800 9.27e-02 8.32e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 27 2.44e-01 3.65e-01 0.1830 0.058700 0.173000 5.98e-01 1.20e-01
TP53 Regulates Transcription of Cell Cycle Genes 43 2.44e-01 3.66e-01 0.1510 -0.049700 0.143000 5.73e-01 1.06e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 2.45e-01 3.66e-01 0.2660 0.027800 0.265000 8.62e-01 9.85e-02
RHOBTB1 GTPase cycle 18 2.45e-01 3.67e-01 0.2210 0.117000 0.187000 3.92e-01 1.69e-01
Meiosis 38 2.48e-01 3.70e-01 0.1560 -0.156000 -0.004310 9.67e-02 9.63e-01
Unfolded Protein Response (UPR) 70 2.48e-01 3.70e-01 0.1170 0.115000 -0.018900 9.65e-02 7.85e-01
RNA Polymerase II Transcription Termination 42 2.48e-01 3.70e-01 0.1540 -0.093700 0.122000 2.94e-01 1.71e-01
Uptake and actions of bacterial toxins 19 2.49e-01 3.70e-01 0.2180 0.216000 0.032700 1.04e-01 8.05e-01
SHC1 events in ERBB2 signaling 11 2.50e-01 3.71e-01 0.2960 0.279000 -0.099000 1.09e-01 5.70e-01
Regulation of TP53 Activity through Phosphorylation 76 2.50e-01 3.71e-01 0.1150 -0.086000 0.075800 1.96e-01 2.55e-01
PI3K Cascade 18 2.50e-01 3.71e-01 0.2280 -0.019700 0.227000 8.85e-01 9.61e-02
Signaling by Hippo 12 2.51e-01 3.71e-01 0.2840 0.261000 -0.113000 1.18e-01 4.99e-01
Signaling by FGFR2 IIIa TM 14 2.52e-01 3.73e-01 0.2590 -0.051600 0.254000 7.39e-01 9.99e-02
Initiation of Nuclear Envelope (NE) Reformation 17 2.54e-01 3.74e-01 0.2340 0.231000 -0.037700 9.90e-02 7.88e-01
Ca-dependent events 21 2.55e-01 3.75e-01 0.2070 0.206000 0.014800 1.02e-01 9.06e-01
Nuclear signaling by ERBB4 16 2.57e-01 3.78e-01 0.2430 0.230000 -0.077300 1.11e-01 5.93e-01
Citric acid cycle (TCA cycle) 19 2.59e-01 3.80e-01 0.2100 0.129000 0.166000 3.32e-01 2.10e-01
mRNA Capping 25 2.60e-01 3.81e-01 0.1940 -0.073500 0.180000 5.25e-01 1.20e-01
Caspase activation via extrinsic apoptotic signalling pathway 15 2.60e-01 3.81e-01 0.2460 0.245000 -0.024800 1.01e-01 8.68e-01
NCAM signaling for neurite out-growth 22 2.62e-01 3.83e-01 0.1960 -0.082900 -0.178000 5.01e-01 1.50e-01
APC/C-mediated degradation of cell cycle proteins 77 2.63e-01 3.84e-01 0.1070 0.010100 0.106000 8.79e-01 1.07e-01
Regulation of mitotic cell cycle 77 2.63e-01 3.84e-01 0.1070 0.010100 0.106000 8.79e-01 1.07e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 13 2.67e-01 3.90e-01 0.2510 0.169000 0.185000 2.90e-01 2.48e-01
Signaling by FGFR1 28 2.69e-01 3.92e-01 0.1770 0.177000 -0.002780 1.06e-01 9.80e-01
Triglyceride metabolism 16 2.71e-01 3.95e-01 0.2410 0.196000 -0.141000 1.75e-01 3.30e-01
Protein ubiquitination 59 2.73e-01 3.97e-01 0.1180 0.102000 0.058000 1.75e-01 4.42e-01
Intrinsic Pathway for Apoptosis 46 2.74e-01 3.98e-01 0.1340 0.126000 0.044900 1.39e-01 5.99e-01
RHOBTB GTPase Cycle 28 2.76e-01 4.00e-01 0.1710 0.053200 0.163000 6.26e-01 1.36e-01
Signaling by BMP 14 2.79e-01 4.04e-01 0.2380 0.160000 0.176000 3.00e-01 2.55e-01
Signaling by ERBB4 31 2.80e-01 4.04e-01 0.1700 0.156000 -0.066200 1.32e-01 5.24e-01
Class I peroxisomal membrane protein import 19 2.81e-01 4.04e-01 0.2180 -0.124000 0.180000 3.49e-01 1.75e-01
RORA activates gene expression 10 2.81e-01 4.04e-01 0.2960 0.284000 -0.084500 1.20e-01 6.44e-01
PRC2 methylates histones and DNA 11 2.81e-01 4.04e-01 0.2740 -0.272000 -0.038100 1.19e-01 8.27e-01
Signaling by TGF-beta Receptor Complex 63 2.82e-01 4.06e-01 0.1150 0.115000 0.009380 1.16e-01 8.98e-01
Formation of HIV elongation complex in the absence of HIV Tat 36 2.83e-01 4.07e-01 0.1560 -0.043500 0.150000 6.52e-01 1.21e-01
ATF4 activates genes in response to endoplasmic reticulum stress 23 2.84e-01 4.07e-01 0.1870 -0.060600 -0.177000 6.15e-01 1.43e-01
Regulation of APC/C activators between G1/S and early anaphase 70 2.85e-01 4.07e-01 0.1100 -0.001720 0.110000 9.80e-01 1.14e-01
Translation of structural proteins 26 2.85e-01 4.07e-01 0.1730 0.103000 0.140000 3.65e-01 2.18e-01
Class B/2 (Secretin family receptors) 26 2.85e-01 4.07e-01 0.1730 0.122000 0.123000 2.83e-01 2.78e-01
Synthesis of PA 18 2.88e-01 4.11e-01 0.2090 -0.081100 -0.193000 5.52e-01 1.57e-01
FGFR2 alternative splicing 21 2.89e-01 4.13e-01 0.2040 -0.087700 0.184000 4.87e-01 1.44e-01
Formation of RNA Pol II elongation complex 48 2.91e-01 4.15e-01 0.1290 0.026900 0.126000 7.47e-01 1.31e-01
RNA Polymerase II Transcription Elongation 48 2.91e-01 4.15e-01 0.1290 0.026900 0.126000 7.47e-01 1.31e-01
CD28 co-stimulation 27 2.92e-01 4.15e-01 0.1680 0.103000 0.134000 3.56e-01 2.30e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 32 2.92e-01 4.15e-01 0.1640 -0.053500 0.155000 6.01e-01 1.30e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 12 2.94e-01 4.16e-01 0.2560 0.245000 0.071000 1.41e-01 6.70e-01
Trafficking of AMPA receptors 12 2.94e-01 4.16e-01 0.2560 0.245000 0.071000 1.41e-01 6.70e-01
PKA activation 10 2.94e-01 4.16e-01 0.2960 0.224000 -0.193000 2.19e-01 2.91e-01
AURKA Activation by TPX2 58 2.95e-01 4.17e-01 0.1150 0.072700 0.088500 3.39e-01 2.44e-01
G2/M DNA damage checkpoint 53 2.96e-01 4.18e-01 0.1230 -0.123000 -0.004520 1.21e-01 9.55e-01
SLC transporter disorders 49 2.99e-01 4.21e-01 0.1330 -0.111000 0.072400 1.79e-01 3.82e-01
RMTs methylate histone arginines 25 3.01e-01 4.23e-01 0.1850 -0.150000 0.109000 1.96e-01 3.45e-01
FOXO-mediated transcription 46 3.01e-01 4.23e-01 0.1300 0.125000 0.033900 1.43e-01 6.92e-01
Heparan sulfate/heparin (HS-GAG) metabolism 19 3.03e-01 4.26e-01 0.1970 0.133000 0.146000 3.16e-01 2.71e-01
FGFR2 mutant receptor activation 15 3.04e-01 4.26e-01 0.2360 -0.102000 0.214000 4.96e-01 1.52e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 41 3.13e-01 4.38e-01 0.1430 0.094300 -0.107000 2.97e-01 2.36e-01
Metabolism of vitamins and cofactors 107 3.15e-01 4.40e-01 0.0827 0.073100 0.038700 1.93e-01 4.91e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 3.20e-01 4.47e-01 0.1970 -0.193000 -0.037300 1.45e-01 7.78e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 3.20e-01 4.47e-01 0.1970 -0.193000 -0.037300 1.45e-01 7.78e-01
Signaling by FLT3 fusion proteins 17 3.22e-01 4.48e-01 0.2170 0.198000 -0.088500 1.59e-01 5.28e-01
Glycogen synthesis 11 3.22e-01 4.48e-01 0.2650 0.260000 -0.054200 1.36e-01 7.56e-01
Glycogen storage diseases 10 3.22e-01 4.48e-01 0.2850 0.189000 -0.213000 3.00e-01 2.45e-01
Signalling to RAS 13 3.25e-01 4.51e-01 0.2340 0.218000 0.085700 1.74e-01 5.93e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 14 3.25e-01 4.51e-01 0.2230 0.161000 0.154000 2.97e-01 3.18e-01
E2F mediated regulation of DNA replication 18 3.27e-01 4.54e-01 0.1970 -0.173000 -0.093600 2.03e-01 4.92e-01
Cytochrome c-mediated apoptotic response 10 3.30e-01 4.57e-01 0.2690 0.266000 0.035500 1.45e-01 8.46e-01
Nucleotide salvage 18 3.30e-01 4.57e-01 0.2090 0.174000 -0.117000 2.02e-01 3.92e-01
Separation of Sister Chromatids 145 3.33e-01 4.60e-01 0.0719 -0.005400 0.071700 9.11e-01 1.38e-01
Signaling by FGFR4 25 3.33e-01 4.60e-01 0.1760 0.155000 -0.084900 1.81e-01 4.63e-01
Glutathione conjugation 20 3.34e-01 4.60e-01 0.1960 0.084100 -0.177000 5.15e-01 1.70e-01
G0 and Early G1 24 3.36e-01 4.62e-01 0.1800 -0.150000 0.099900 2.04e-01 3.97e-01
Inhibition of DNA recombination at telomere 16 3.40e-01 4.66e-01 0.2160 -0.060700 0.207000 6.74e-01 1.51e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 10 3.40e-01 4.66e-01 0.2780 -0.187000 0.206000 3.07e-01 2.60e-01
PKA-mediated phosphorylation of CREB 11 3.42e-01 4.69e-01 0.2640 0.173000 -0.199000 3.19e-01 2.53e-01
Interferon gamma signaling 55 3.44e-01 4.70e-01 0.1120 0.107000 0.032800 1.72e-01 6.74e-01
APC-Cdc20 mediated degradation of Nek2A 24 3.44e-01 4.70e-01 0.1710 -0.170000 -0.015500 1.49e-01 8.95e-01
Loss of Nlp from mitotic centrosomes 55 3.45e-01 4.70e-01 0.1100 0.059400 0.092700 4.47e-01 2.35e-01
Loss of proteins required for interphase microtubule organization from the centrosome 55 3.45e-01 4.70e-01 0.1100 0.059400 0.092700 4.47e-01 2.35e-01
TRAF6 mediated IRF7 activation 15 3.50e-01 4.76e-01 0.2150 0.215000 0.012100 1.50e-01 9.35e-01
Interconversion of nucleotide di- and triphosphates 22 3.51e-01 4.77e-01 0.1810 -0.176000 0.041100 1.53e-01 7.39e-01
Interferon alpha/beta signaling 51 3.51e-01 4.77e-01 0.1150 0.035100 0.109000 6.65e-01 1.78e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 22 3.52e-01 4.78e-01 0.1810 0.051800 -0.174000 6.74e-01 1.59e-01
Transcription of E2F targets under negative control by DREAM complex 18 3.58e-01 4.83e-01 0.2010 -0.178000 0.092600 1.91e-01 4.97e-01
Formation of the Early Elongation Complex 29 3.58e-01 4.83e-01 0.1550 -0.016000 0.154000 8.81e-01 1.52e-01
Formation of the HIV-1 Early Elongation Complex 29 3.58e-01 4.83e-01 0.1550 -0.016000 0.154000 8.81e-01 1.52e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 35 3.58e-01 4.83e-01 0.1440 -0.062600 0.130000 5.22e-01 1.85e-01
HIV Transcription Elongation 35 3.58e-01 4.83e-01 0.1440 -0.062600 0.130000 5.22e-01 1.85e-01
Tat-mediated elongation of the HIV-1 transcript 35 3.58e-01 4.83e-01 0.1440 -0.062600 0.130000 5.22e-01 1.85e-01
Heme biosynthesis 10 3.59e-01 4.83e-01 0.2650 -0.052500 0.259000 7.74e-01 1.56e-01
The role of Nef in HIV-1 replication and disease pathogenesis 19 3.59e-01 4.83e-01 0.1930 0.185000 -0.055900 1.63e-01 6.73e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 22 3.61e-01 4.85e-01 0.1700 0.108000 0.131000 3.82e-01 2.88e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 14 3.61e-01 4.85e-01 0.2270 0.197000 -0.113000 2.02e-01 4.66e-01
Assembly Of The HIV Virion 14 3.63e-01 4.87e-01 0.2150 0.205000 0.064000 1.84e-01 6.79e-01
DNA Double Strand Break Response 35 3.67e-01 4.91e-01 0.1390 -0.013200 0.138000 8.93e-01 1.57e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 21 3.70e-01 4.95e-01 0.1780 -0.003130 0.178000 9.80e-01 1.59e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 3.70e-01 4.95e-01 0.1700 0.170000 -0.001850 1.60e-01 9.88e-01
RNA Polymerase II Pre-transcription Events 65 3.71e-01 4.95e-01 0.0988 0.031800 0.093500 6.58e-01 1.93e-01
Processing of Capped Intronless Pre-mRNA 21 3.73e-01 4.97e-01 0.1820 -0.167000 0.072000 1.86e-01 5.68e-01
Assembly of collagen fibrils and other multimeric structures 14 3.74e-01 4.98e-01 0.2180 0.216000 -0.032300 1.62e-01 8.34e-01
Nicotinate metabolism 19 3.75e-01 4.99e-01 0.1860 0.186000 -0.013800 1.61e-01 9.17e-01
Regulation of KIT signaling 11 3.82e-01 5.08e-01 0.2360 0.076500 0.223000 6.61e-01 2.00e-01
Telomere Extension By Telomerase 20 3.89e-01 5.16e-01 0.1840 -0.128000 0.132000 3.23e-01 3.06e-01
DAG and IP3 signaling 26 3.90e-01 5.17e-01 0.1610 0.130000 -0.095300 2.53e-01 4.01e-01
The NLRP3 inflammasome 12 3.97e-01 5.26e-01 0.2240 0.222000 0.030500 1.84e-01 8.55e-01
Transcription of the HIV genome 55 4.00e-01 5.29e-01 0.1070 -0.022000 0.105000 7.79e-01 1.80e-01
TGF-beta receptor signaling activates SMADs 32 4.01e-01 5.30e-01 0.1360 0.135000 0.021500 1.88e-01 8.33e-01
Diseases of DNA repair 10 4.03e-01 5.32e-01 0.2550 -0.166000 0.193000 3.63e-01 2.91e-01
HCMV Infection 71 4.04e-01 5.33e-01 0.0928 -0.006570 0.092600 9.24e-01 1.78e-01
Zinc transporters 11 4.05e-01 5.33e-01 0.2380 0.061600 -0.230000 7.24e-01 1.87e-01
Ovarian tumor domain proteases 28 4.10e-01 5.39e-01 0.1470 0.146000 -0.012900 1.82e-01 9.06e-01
Formation of Incision Complex in GG-NER 36 4.11e-01 5.40e-01 0.1320 -0.120000 0.055000 2.14e-01 5.68e-01
Reproduction 43 4.12e-01 5.40e-01 0.1170 -0.117000 -0.006320 1.86e-01 9.43e-01
Processing of Intronless Pre-mRNAs 14 4.14e-01 5.42e-01 0.2100 -0.084300 0.193000 5.85e-01 2.12e-01
Interleukin-12 family signaling 41 4.14e-01 5.42e-01 0.1180 0.022900 0.116000 8.00e-01 2.00e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 34 4.17e-01 5.45e-01 0.1310 -0.007270 0.131000 9.42e-01 1.86e-01
Cytochrome P450 - arranged by substrate type 14 4.19e-01 5.47e-01 0.2000 0.195000 0.046500 2.08e-01 7.63e-01
CTLA4 inhibitory signaling 16 4.21e-01 5.49e-01 0.1860 0.055700 0.177000 7.00e-01 2.20e-01
Metalloprotease DUBs 16 4.29e-01 5.58e-01 0.1820 0.159000 0.088800 2.72e-01 5.39e-01
CaM pathway 20 4.29e-01 5.58e-01 0.1690 0.168000 -0.021700 1.94e-01 8.67e-01
Calmodulin induced events 20 4.29e-01 5.58e-01 0.1690 0.168000 -0.021700 1.94e-01 8.67e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 18 4.32e-01 5.61e-01 0.1700 0.137000 0.101000 3.15e-01 4.57e-01
Circadian Clock 50 4.32e-01 5.61e-01 0.1080 0.103000 -0.031400 2.07e-01 7.01e-01
Heme signaling 24 4.33e-01 5.61e-01 0.1500 0.145000 0.037500 2.19e-01 7.50e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 4.34e-01 5.62e-01 0.2120 0.206000 0.048500 2.17e-01 7.71e-01
Post-translational modification: synthesis of GPI-anchored proteins 28 4.35e-01 5.62e-01 0.1420 -0.024700 0.140000 8.21e-01 1.99e-01
Synthesis of substrates in N-glycan biosythesis 48 4.37e-01 5.64e-01 0.1100 0.099800 -0.047000 2.32e-01 5.74e-01
ER Quality Control Compartment (ERQC) 18 4.37e-01 5.64e-01 0.1780 0.171000 -0.049700 2.09e-01 7.15e-01
Rap1 signalling 10 4.43e-01 5.71e-01 0.2250 0.185000 0.128000 3.11e-01 4.83e-01
Cyclin A/B1/B2 associated events during G2/M transition 22 4.51e-01 5.80e-01 0.1530 0.036800 0.148000 7.65e-01 2.29e-01
Molecules associated with elastic fibres 12 4.53e-01 5.81e-01 0.2070 -0.038000 -0.203000 8.20e-01 2.23e-01
Membrane binding and targetting of GAG proteins 12 4.53e-01 5.81e-01 0.2120 0.208000 -0.041300 2.12e-01 8.04e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 4.53e-01 5.81e-01 0.2120 0.208000 -0.041300 2.12e-01 8.04e-01
TICAM1-dependent activation of IRF3/IRF7 12 4.53e-01 5.81e-01 0.2090 -0.001380 0.209000 9.93e-01 2.09e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 22 4.58e-01 5.86e-01 0.1500 0.140000 0.053700 2.56e-01 6.63e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 4.62e-01 5.90e-01 0.2110 -0.059600 0.202000 7.21e-01 2.25e-01
CLEC7A (Dectin-1) induces NFAT activation 11 4.63e-01 5.91e-01 0.2200 -0.058800 0.212000 7.36e-01 2.24e-01
RHOU GTPase cycle 26 4.65e-01 5.93e-01 0.1380 0.136000 0.023200 2.29e-01 8.38e-01
Role of phospholipids in phagocytosis 16 4.66e-01 5.94e-01 0.1840 0.152000 -0.104000 2.91e-01 4.74e-01
RUNX2 regulates osteoblast differentiation 11 4.68e-01 5.95e-01 0.2080 0.183000 0.099600 2.95e-01 5.68e-01
Recruitment of NuMA to mitotic centrosomes 63 4.71e-01 5.99e-01 0.0876 0.025400 0.083800 7.28e-01 2.51e-01
Cell surface interactions at the vascular wall 57 4.72e-01 6.00e-01 0.0939 0.093800 -0.001610 2.21e-01 9.83e-01
RNA Pol II CTD phosphorylation and interaction with CE 23 4.73e-01 6.00e-01 0.1500 -0.035300 0.145000 7.70e-01 2.28e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 23 4.73e-01 6.00e-01 0.1500 -0.035300 0.145000 7.70e-01 2.28e-01
Interferon Signaling 142 4.74e-01 6.00e-01 0.0602 -0.008890 0.059500 8.56e-01 2.23e-01
TRAF6 mediated NF-kB activation 18 4.74e-01 6.00e-01 0.1680 0.165000 -0.028900 2.24e-01 8.32e-01
Sensory processing of sound 25 4.75e-01 6.00e-01 0.1370 0.061100 0.122000 5.98e-01 2.90e-01
Sensory processing of sound by inner hair cells of the cochlea 25 4.75e-01 6.00e-01 0.1370 0.061100 0.122000 5.98e-01 2.90e-01
Diseases of programmed cell death 35 4.77e-01 6.02e-01 0.1150 0.055000 0.101000 5.74e-01 3.01e-01
Synthesis of PIPs at the Golgi membrane 12 4.78e-01 6.02e-01 0.2070 0.195000 -0.069600 2.43e-01 6.76e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 33 4.82e-01 6.07e-01 0.1170 0.087600 0.077700 3.84e-01 4.40e-01
Metabolism of porphyrins 15 4.84e-01 6.08e-01 0.1740 0.092000 0.148000 5.38e-01 3.23e-01
Josephin domain DUBs 10 4.89e-01 6.14e-01 0.2220 0.214000 -0.058500 2.41e-01 7.49e-01
Termination of O-glycan biosynthesis 10 4.90e-01 6.15e-01 0.2120 0.190000 0.092800 2.98e-01 6.12e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 26 4.94e-01 6.18e-01 0.1380 -0.128000 0.050100 2.58e-01 6.59e-01
HIV elongation arrest and recovery 26 4.94e-01 6.18e-01 0.1350 -0.005400 0.135000 9.62e-01 2.35e-01
Pausing and recovery of HIV elongation 26 4.94e-01 6.18e-01 0.1350 -0.005400 0.135000 9.62e-01 2.35e-01
Nuclear Envelope (NE) Reassembly 60 4.96e-01 6.19e-01 0.0862 0.031900 0.080100 6.70e-01 2.84e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 16 4.96e-01 6.19e-01 0.1650 -0.099600 -0.132000 4.90e-01 3.63e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 4.99e-01 6.21e-01 0.1770 -0.176000 0.018700 2.38e-01 9.00e-01
Signaling by ERBB2 32 5.02e-01 6.25e-01 0.1190 0.119000 0.008710 2.46e-01 9.32e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 5.05e-01 6.28e-01 0.1930 0.171000 -0.088300 2.86e-01 5.82e-01
Protein-protein interactions at synapses 31 5.06e-01 6.28e-01 0.1220 0.018700 -0.121000 8.57e-01 2.45e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 16 5.08e-01 6.30e-01 0.1620 -0.136000 -0.089000 3.47e-01 5.38e-01
FLT3 signaling in disease 25 5.13e-01 6.36e-01 0.1320 0.132000 0.012100 2.54e-01 9.16e-01
Phase I - Functionalization of compounds 30 5.17e-01 6.40e-01 0.1210 -0.003360 -0.121000 9.75e-01 2.53e-01
Chaperone Mediated Autophagy 12 5.18e-01 6.40e-01 0.1850 -0.158000 -0.096300 3.44e-01 5.64e-01
Bile acid and bile salt metabolism 14 5.18e-01 6.40e-01 0.1830 0.150000 -0.105000 3.33e-01 4.95e-01
Metabolism of cofactors 17 5.19e-01 6.40e-01 0.1570 0.151000 0.043000 2.81e-01 7.59e-01
Inactivation, recovery and regulation of the phototransduction cascade 15 5.20e-01 6.40e-01 0.1730 -0.169000 0.034100 2.57e-01 8.19e-01
The phototransduction cascade 15 5.20e-01 6.40e-01 0.1730 -0.169000 0.034100 2.57e-01 8.19e-01
DAP12 interactions 23 5.20e-01 6.40e-01 0.1410 0.133000 -0.046300 2.71e-01 7.01e-01
Diseases of metabolism 120 5.22e-01 6.40e-01 0.0599 0.059500 0.006770 2.62e-01 8.99e-01
Diseases associated with O-glycosylation of proteins 21 5.22e-01 6.40e-01 0.1400 -0.055500 -0.128000 6.60e-01 3.09e-01
Keratan sulfate biosynthesis 15 5.23e-01 6.40e-01 0.1650 0.152000 0.064800 3.08e-01 6.64e-01
Glutamate Neurotransmitter Release Cycle 11 5.23e-01 6.40e-01 0.1910 -0.125000 -0.144000 4.71e-01 4.08e-01
Centrosome maturation 64 5.25e-01 6.42e-01 0.0800 0.030200 0.074100 6.77e-01 3.07e-01
Recruitment of mitotic centrosome proteins and complexes 64 5.25e-01 6.42e-01 0.0800 0.030200 0.074100 6.77e-01 3.07e-01
Tie2 Signaling 10 5.27e-01 6.44e-01 0.2030 0.199000 0.040200 2.75e-01 8.26e-01
Elastic fibre formation 17 5.28e-01 6.44e-01 0.1640 0.122000 -0.110000 3.84e-01 4.34e-01
CD28 dependent PI3K/Akt signaling 18 5.33e-01 6.48e-01 0.1570 -0.064800 0.143000 6.34e-01 2.94e-01
Mitotic Prometaphase 154 5.33e-01 6.48e-01 0.0545 -0.036400 0.040500 4.37e-01 3.87e-01
RND3 GTPase cycle 28 5.36e-01 6.52e-01 0.1180 0.105000 0.055000 3.38e-01 6.15e-01
Signaling by FGFR2 in disease 23 5.40e-01 6.55e-01 0.1380 -0.111000 0.082800 3.57e-01 4.92e-01
Diseases of glycosylation 68 5.42e-01 6.58e-01 0.0749 0.056200 0.049600 4.24e-01 4.80e-01
Nuclear Receptor transcription pathway 25 5.43e-01 6.58e-01 0.1310 -0.057000 0.118000 6.22e-01 3.07e-01
The citric acid (TCA) cycle and respiratory electron transport 120 5.44e-01 6.58e-01 0.0582 0.002350 0.058200 9.65e-01 2.73e-01
Regulation of FZD by ubiquitination 11 5.46e-01 6.60e-01 0.1870 -0.176000 -0.062500 3.12e-01 7.20e-01
Signaling by FGFR 51 5.47e-01 6.61e-01 0.0859 0.069900 0.049900 3.88e-01 5.38e-01
Signaling by FGFR in disease 39 5.47e-01 6.61e-01 0.1050 0.090900 -0.052200 3.27e-01 5.73e-01
DAP12 signaling 21 5.49e-01 6.62e-01 0.1400 0.136000 -0.034600 2.81e-01 7.84e-01
PERK regulates gene expression 26 5.50e-01 6.62e-01 0.1190 -0.084600 -0.084300 4.56e-01 4.57e-01
Signaling by NTRK3 (TRKC) 12 5.60e-01 6.73e-01 0.1750 -0.059600 -0.165000 7.21e-01 3.23e-01
TRAF3-dependent IRF activation pathway 13 5.61e-01 6.74e-01 0.1700 0.169000 0.023300 2.93e-01 8.84e-01
Downstream signal transduction 21 5.66e-01 6.77e-01 0.1300 0.116000 0.058900 3.56e-01 6.41e-01
Disorders of Developmental Biology 10 5.67e-01 6.77e-01 0.1890 0.176000 0.070500 3.36e-01 6.99e-01
Disorders of Nervous System Development 10 5.67e-01 6.77e-01 0.1890 0.176000 0.070500 3.36e-01 6.99e-01
Loss of function of MECP2 in Rett syndrome 10 5.67e-01 6.77e-01 0.1890 0.176000 0.070500 3.36e-01 6.99e-01
Pervasive developmental disorders 10 5.67e-01 6.77e-01 0.1890 0.176000 0.070500 3.36e-01 6.99e-01
Trafficking and processing of endosomal TLR 10 5.67e-01 6.77e-01 0.1940 0.194000 0.005150 2.89e-01 9.77e-01
Mitotic Spindle Checkpoint 96 5.67e-01 6.77e-01 0.0626 -0.062500 -0.003650 2.91e-01 9.51e-01
SUMOylation of DNA methylation proteins 14 5.68e-01 6.77e-01 0.1590 -0.141000 -0.073000 3.60e-01 6.37e-01
Assembly and cell surface presentation of NMDA receptors 11 5.77e-01 6.87e-01 0.1890 -0.142000 0.125000 4.16e-01 4.72e-01
Regulation of BACH1 activity 11 5.78e-01 6.88e-01 0.1760 -0.120000 -0.128000 4.91e-01 4.62e-01
Apoptotic factor-mediated response 15 5.81e-01 6.90e-01 0.1540 0.152000 0.021700 3.08e-01 8.84e-01
Anchoring of the basal body to the plasma membrane 79 5.84e-01 6.92e-01 0.0684 -0.012000 0.067300 8.54e-01 3.02e-01
Caspase-mediated cleavage of cytoskeletal proteins 10 5.84e-01 6.92e-01 0.1950 0.167000 -0.102000 3.62e-01 5.76e-01
Glyoxylate metabolism and glycine degradation 19 5.84e-01 6.92e-01 0.1420 -0.074000 0.121000 5.77e-01 3.62e-01
KSRP (KHSRP) binds and destabilizes mRNA 15 5.85e-01 6.92e-01 0.1490 -0.108000 -0.102000 4.68e-01 4.94e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 5.85e-01 6.92e-01 0.1430 -0.139000 0.031600 3.06e-01 8.17e-01
Inflammasomes 16 5.87e-01 6.93e-01 0.1440 0.120000 0.079200 4.05e-01 5.83e-01
Vitamin B5 (pantothenate) metabolism 11 5.87e-01 6.93e-01 0.1750 0.164000 0.060200 3.45e-01 7.30e-01
Nicotinamide salvaging 11 5.91e-01 6.97e-01 0.1780 0.177000 0.009360 3.09e-01 9.57e-01
Senescence-Associated Secretory Phenotype (SASP) 41 5.95e-01 7.00e-01 0.0903 0.087400 0.022900 3.34e-01 8.00e-01
Sulfur amino acid metabolism 15 5.98e-01 7.03e-01 0.1570 -0.104000 0.117000 4.84e-01 4.33e-01
Ion homeostasis 26 6.01e-01 7.07e-01 0.1180 0.078700 -0.088400 4.88e-01 4.35e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 6.03e-01 7.08e-01 0.1470 -0.142000 -0.038300 3.42e-01 7.98e-01
Effects of PIP2 hydrolysis 19 6.04e-01 7.09e-01 0.1380 -0.103000 0.091000 4.35e-01 4.93e-01
APC/C:Cdc20 mediated degradation of Cyclin B 22 6.08e-01 7.13e-01 0.1220 -0.122000 -0.002300 3.21e-01 9.85e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 19 6.12e-01 7.16e-01 0.1270 0.095700 0.082800 4.70e-01 5.32e-01
TNF signaling 37 6.14e-01 7.18e-01 0.0915 0.031300 0.086000 7.42e-01 3.66e-01
CD209 (DC-SIGN) signaling 15 6.19e-01 7.23e-01 0.1440 0.142000 0.024900 3.42e-01 8.67e-01
RAS processing 15 6.21e-01 7.24e-01 0.1410 -0.074700 -0.119000 6.17e-01 4.23e-01
Resolution of D-Loop Structures 27 6.24e-01 7.28e-01 0.1100 -0.105000 0.032700 3.45e-01 7.69e-01
Polo-like kinase mediated events 15 6.30e-01 7.33e-01 0.1390 0.080100 0.113000 5.91e-01 4.49e-01
Sensory Perception 61 6.31e-01 7.34e-01 0.0704 0.007270 0.070000 9.22e-01 3.45e-01
Mitochondrial biogenesis 50 6.32e-01 7.34e-01 0.0759 -0.036600 -0.066500 6.55e-01 4.17e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 82 6.33e-01 7.34e-01 0.0608 0.004980 0.060600 9.38e-01 3.44e-01
Branched-chain amino acid catabolism 19 6.40e-01 7.42e-01 0.1300 -0.095100 0.088300 4.73e-01 5.06e-01
Ephrin signaling 11 6.40e-01 7.42e-01 0.1700 0.087700 -0.145000 6.15e-01 4.05e-01
Pausing and recovery of Tat-mediated HIV elongation 25 6.45e-01 7.44e-01 0.1100 -0.030600 0.106000 7.91e-01 3.60e-01
Tat-mediated HIV elongation arrest and recovery 25 6.45e-01 7.44e-01 0.1100 -0.030600 0.106000 7.91e-01 3.60e-01
IRS-mediated signalling 21 6.45e-01 7.44e-01 0.1200 -0.028700 0.116000 8.20e-01 3.57e-01
Neurotransmitter release cycle 19 6.46e-01 7.44e-01 0.1200 -0.050000 -0.109000 7.06e-01 4.09e-01
HIV Transcription Initiation 37 6.48e-01 7.44e-01 0.0871 0.018200 0.085100 8.49e-01 3.71e-01
RNA Polymerase II HIV Promoter Escape 37 6.48e-01 7.44e-01 0.0871 0.018200 0.085100 8.49e-01 3.71e-01
RNA Polymerase II Promoter Escape 37 6.48e-01 7.44e-01 0.0871 0.018200 0.085100 8.49e-01 3.71e-01
RNA Polymerase II Transcription Initiation 37 6.48e-01 7.44e-01 0.0871 0.018200 0.085100 8.49e-01 3.71e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 37 6.48e-01 7.44e-01 0.0871 0.018200 0.085100 8.49e-01 3.71e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 37 6.48e-01 7.44e-01 0.0871 0.018200 0.085100 8.49e-01 3.71e-01
VEGFR2 mediated cell proliferation 16 6.50e-01 7.45e-01 0.1380 0.074700 -0.117000 6.05e-01 4.20e-01
Base-Excision Repair, AP Site Formation 13 6.51e-01 7.45e-01 0.1480 -0.148000 0.004190 3.55e-01 9.79e-01
Response of EIF2AK1 (HRI) to heme deficiency 13 6.52e-01 7.45e-01 0.1510 0.145000 -0.041500 3.65e-01 7.96e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 23 6.53e-01 7.46e-01 0.1130 -0.110000 0.027300 3.63e-01 8.21e-01
Signaling by NTRK2 (TRKB) 16 6.56e-01 7.49e-01 0.1280 0.108000 0.068700 4.54e-01 6.34e-01
Metabolism of nitric oxide: NOS3 activation and regulation 11 6.59e-01 7.51e-01 0.1550 0.058600 0.143000 7.37e-01 4.10e-01
Cargo trafficking to the periciliary membrane 40 6.59e-01 7.51e-01 0.0805 -0.057500 -0.056400 5.30e-01 5.38e-01
Glycolysis 57 6.66e-01 7.58e-01 0.0682 0.011600 0.067200 8.80e-01 3.81e-01
DCC mediated attractive signaling 11 6.67e-01 7.58e-01 0.1610 -0.148000 0.062700 3.96e-01 7.19e-01
Glucose metabolism 72 6.67e-01 7.58e-01 0.0593 0.046500 0.036800 4.96e-01 5.91e-01
Cell junction organization 25 6.69e-01 7.59e-01 0.1070 0.071400 -0.080300 5.37e-01 4.88e-01
Resolution of Sister Chromatid Cohesion 90 6.69e-01 7.59e-01 0.0541 -0.053400 -0.008580 3.83e-01 8.88e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 13 6.71e-01 7.60e-01 0.1470 -0.134000 0.059600 4.03e-01 7.10e-01
Formation of tubulin folding intermediates by CCT/TriC 14 6.75e-01 7.64e-01 0.1320 0.103000 0.082300 5.05e-01 5.94e-01
Mitochondrial Fatty Acid Beta-Oxidation 25 6.77e-01 7.65e-01 0.1020 -0.102000 -0.004630 3.80e-01 9.68e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 6.77e-01 7.65e-01 0.1450 0.134000 -0.054800 4.03e-01 7.33e-01
Synthesis of bile acids and bile salts 13 6.78e-01 7.65e-01 0.1460 0.115000 -0.090100 4.73e-01 5.74e-01
IKK complex recruitment mediated by RIP1 17 6.82e-01 7.68e-01 0.1180 0.094100 0.071700 5.02e-01 6.09e-01
Metal ion SLC transporters 15 6.85e-01 7.71e-01 0.1330 0.124000 -0.046700 4.05e-01 7.54e-01
Downregulation of ERBB2 signaling 15 6.90e-01 7.77e-01 0.1270 0.127000 0.009970 3.95e-01 9.47e-01
Cell-Cell communication 46 6.92e-01 7.77e-01 0.0755 0.064200 -0.039700 4.52e-01 6.42e-01
RND2 GTPase cycle 32 6.92e-01 7.77e-01 0.0903 0.078200 -0.045100 4.44e-01 6.59e-01
SUMOylation of transcription factors 12 6.94e-01 7.78e-01 0.1370 0.104000 0.089700 5.33e-01 5.91e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 28 6.99e-01 7.83e-01 0.0891 0.064500 0.061500 5.55e-01 5.74e-01
Transcriptional activation of mitochondrial biogenesis 36 6.99e-01 7.83e-01 0.0791 -0.035200 -0.070800 7.15e-01 4.63e-01
FCERI mediated Ca+2 mobilization 25 7.11e-01 7.95e-01 0.0945 0.093900 0.011000 4.17e-01 9.24e-01
DNA Damage Recognition in GG-NER 35 7.12e-01 7.96e-01 0.0824 -0.076900 0.029700 4.32e-01 7.62e-01
TNFR1-induced proapoptotic signaling 11 7.15e-01 7.98e-01 0.1380 -0.117000 -0.072600 5.00e-01 6.77e-01
TICAM1, RIP1-mediated IKK complex recruitment 17 7.17e-01 8.00e-01 0.1110 0.100000 0.047700 4.75e-01 7.34e-01
Regulation of RUNX1 Expression and Activity 15 7.20e-01 8.01e-01 0.1170 0.061700 0.099400 6.79e-01 5.05e-01
CDC6 association with the ORC:origin complex 10 7.20e-01 8.01e-01 0.1530 -0.084600 0.127000 6.43e-01 4.85e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 61 7.21e-01 8.02e-01 0.0610 0.058600 -0.017000 4.30e-01 8.18e-01
Signaling by PDGFR in disease 16 7.23e-01 8.03e-01 0.1150 0.016300 0.114000 9.10e-01 4.31e-01
Negative regulators of DDX58/IFIH1 signaling 33 7.27e-01 8.07e-01 0.0832 -0.058200 0.059400 5.63e-01 5.55e-01
Metabolism of nucleotides 68 7.31e-01 8.11e-01 0.0567 -0.053600 0.018700 4.46e-01 7.90e-01
N-glycan antennae elongation in the medial/trans-Golgi 17 7.35e-01 8.13e-01 0.1080 0.104000 0.028600 4.58e-01 8.38e-01
HSF1-dependent transactivation 25 7.35e-01 8.13e-01 0.0875 0.057700 0.065700 6.18e-01 5.70e-01
Respiratory electron transport 81 7.35e-01 8.13e-01 0.0504 -0.000329 0.050400 9.96e-01 4.34e-01
TP53 Regulates Transcription of Cell Death Genes 30 7.37e-01 8.14e-01 0.0855 0.063400 -0.057400 5.48e-01 5.87e-01
Phosphorylation of the APC/C 18 7.38e-01 8.15e-01 0.1060 -0.106000 0.004940 4.36e-01 9.71e-01
RHOV GTPase cycle 24 7.45e-01 8.22e-01 0.0922 0.087700 -0.028700 4.58e-01 8.08e-01
Downregulation of TGF-beta receptor signaling 26 7.46e-01 8.22e-01 0.0841 0.038400 0.074900 7.35e-01 5.09e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 81 7.48e-01 8.23e-01 0.0483 -0.047500 -0.008620 4.61e-01 8.94e-01
Amplification of signal from the kinetochores 81 7.48e-01 8.23e-01 0.0483 -0.047500 -0.008620 4.61e-01 8.94e-01
Nephrin family interactions 13 7.49e-01 8.23e-01 0.1250 -0.116000 0.044600 4.68e-01 7.81e-01
Mitotic Prophase 73 7.51e-01 8.24e-01 0.0530 -0.028600 0.044600 6.73e-01 5.11e-01
Synthesis of glycosylphosphatidylinositol (GPI) 13 7.55e-01 8.27e-01 0.1230 -0.113000 0.049800 4.81e-01 7.56e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 10 7.59e-01 8.30e-01 0.1360 0.002110 -0.135000 9.91e-01 4.58e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 41 7.60e-01 8.30e-01 0.0652 0.024100 0.060600 7.90e-01 5.02e-01
Attenuation phase 19 7.60e-01 8.30e-01 0.0954 0.086000 0.041100 5.16e-01 7.56e-01
Syndecan interactions 10 7.60e-01 8.30e-01 0.1380 0.129000 -0.048700 4.79e-01 7.90e-01
DNA Damage/Telomere Stress Induced Senescence 23 7.60e-01 8.30e-01 0.0892 -0.002040 0.089100 9.86e-01 4.60e-01
Maturation of nucleoprotein 10 7.64e-01 8.32e-01 0.1300 0.073400 0.107000 6.88e-01 5.59e-01
Chondroitin sulfate/dermatan sulfate metabolism 26 7.70e-01 8.38e-01 0.0845 0.041600 -0.073600 7.14e-01 5.16e-01
Interleukin-12 signaling 35 7.70e-01 8.38e-01 0.0682 0.040300 0.055100 6.80e-01 5.73e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 15 7.70e-01 8.38e-01 0.1090 -0.106000 0.025100 4.76e-01 8.67e-01
Interleukin-35 Signalling 11 7.72e-01 8.38e-01 0.1300 -0.103000 0.079300 5.56e-01 6.49e-01
HSF1 activation 21 7.72e-01 8.38e-01 0.0930 -0.085000 0.037700 5.01e-01 7.65e-01
Transcriptional Regulation by VENTX 30 7.74e-01 8.39e-01 0.0753 0.000627 0.075300 9.95e-01 4.76e-01
Metabolism of folate and pterines 11 7.78e-01 8.42e-01 0.1200 0.108000 0.051800 5.35e-01 7.66e-01
Activation of BH3-only proteins 27 7.78e-01 8.42e-01 0.0806 0.075500 -0.028200 4.98e-01 8.00e-01
Potassium Channels 25 7.81e-01 8.42e-01 0.0825 0.080400 -0.018400 4.87e-01 8.73e-01
Dopamine Neurotransmitter Release Cycle 12 7.81e-01 8.42e-01 0.1160 -0.115000 -0.016700 4.92e-01 9.20e-01
Signaling by KIT in disease 17 7.81e-01 8.42e-01 0.0984 -0.001140 0.098400 9.94e-01 4.83e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 17 7.81e-01 8.42e-01 0.0984 -0.001140 0.098400 9.94e-01 4.83e-01
Metabolism of water-soluble vitamins and cofactors 79 7.94e-01 8.53e-01 0.0427 0.030000 0.030400 6.46e-01 6.41e-01
N-Glycan antennae elongation 11 7.94e-01 8.53e-01 0.1160 0.112000 0.029200 5.19e-01 8.67e-01
Regulation of TP53 Expression and Degradation 33 7.95e-01 8.53e-01 0.0697 -0.065700 0.023400 5.14e-01 8.16e-01
IGF1R signaling cascade 23 7.96e-01 8.53e-01 0.0793 0.030200 0.073300 8.02e-01 5.43e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 23 7.96e-01 8.53e-01 0.0793 0.030200 0.073300 8.02e-01 5.43e-01
Transport of vitamins, nucleosides, and related molecules 21 7.96e-01 8.53e-01 0.0882 0.062500 -0.062300 6.21e-01 6.22e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 37 7.96e-01 8.53e-01 0.0665 0.046000 -0.048000 6.29e-01 6.14e-01
Caspase activation via Death Receptors in the presence of ligand 10 7.98e-01 8.53e-01 0.1260 0.112000 -0.059200 5.41e-01 7.46e-01
Neurexins and neuroligins 19 7.98e-01 8.53e-01 0.0869 -0.081900 -0.029200 5.37e-01 8.26e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 16 7.99e-01 8.53e-01 0.0943 -0.033700 -0.088100 8.16e-01 5.42e-01
Mitochondrial calcium ion transport 18 8.00e-01 8.54e-01 0.0940 -0.055500 0.075800 6.84e-01 5.78e-01
Purine catabolism 10 8.01e-01 8.54e-01 0.1220 0.122000 -0.011600 5.05e-01 9.49e-01
Cleavage of the damaged pyrimidine 12 8.03e-01 8.54e-01 0.1080 -0.102000 -0.036100 5.43e-01 8.28e-01
Depyrimidination 12 8.03e-01 8.54e-01 0.1080 -0.102000 -0.036100 5.43e-01 8.28e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 12 8.03e-01 8.54e-01 0.1080 -0.102000 -0.036100 5.43e-01 8.28e-01
Signaling by ERBB2 ECD mutants 10 8.08e-01 8.59e-01 0.1230 -0.103000 0.067700 5.74e-01 7.11e-01
Regulation of pyruvate dehydrogenase (PDH) complex 11 8.13e-01 8.63e-01 0.1160 -0.082300 0.081700 6.37e-01 6.39e-01
Methylation 10 8.18e-01 8.67e-01 0.1190 -0.110000 0.043300 5.46e-01 8.13e-01
Regulation of TP53 Degradation 32 8.19e-01 8.67e-01 0.0667 -0.057200 0.034200 5.76e-01 7.38e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 8.33e-01 8.81e-01 0.0697 0.051000 -0.047500 6.47e-01 6.69e-01
Basigin interactions 14 8.34e-01 8.82e-01 0.0905 -0.032400 -0.084600 8.34e-01 5.84e-01
Integrin cell surface interactions 25 8.35e-01 8.82e-01 0.0673 0.060600 0.029400 6.00e-01 7.99e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 26 8.41e-01 8.88e-01 0.0653 -0.062800 -0.017900 5.80e-01 8.74e-01
Meiotic synapsis 23 8.42e-01 8.88e-01 0.0687 -0.062500 -0.028400 6.04e-01 8.14e-01
IRS-related events triggered by IGF1R 22 8.47e-01 8.92e-01 0.0712 -0.003860 0.071100 9.75e-01 5.64e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 22 8.48e-01 8.92e-01 0.0694 -0.066500 -0.019700 5.89e-01 8.73e-01
Other interleukin signaling 15 8.50e-01 8.93e-01 0.0826 0.074500 0.035800 6.18e-01 8.11e-01
EML4 and NUDC in mitotic spindle formation 85 8.50e-01 8.93e-01 0.0361 -0.035800 0.004300 5.69e-01 9.46e-01
Regulation of PLK1 Activity at G2/M Transition 73 8.53e-01 8.95e-01 0.0368 0.025000 0.027100 7.12e-01 6.90e-01
Signaling by FGFR2 47 8.53e-01 8.95e-01 0.0459 0.037900 0.026000 6.54e-01 7.58e-01
Nonhomologous End-Joining (NHEJ) 28 8.57e-01 8.98e-01 0.0625 -0.028200 0.055700 7.96e-01 6.10e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 57 8.61e-01 9.01e-01 0.0411 0.011800 0.039400 8.78e-01 6.08e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 19 8.64e-01 9.04e-01 0.0738 -0.035000 0.065000 7.92e-01 6.24e-01
Endosomal/Vacuolar pathway 11 8.65e-01 9.04e-01 0.0905 -0.051600 -0.074400 7.67e-01 6.69e-01
Visual phototransduction 30 8.71e-01 9.10e-01 0.0573 -0.033300 0.046600 7.52e-01 6.59e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 8.77e-01 9.14e-01 0.0735 0.073400 0.003710 6.11e-01 9.80e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 8.77e-01 9.14e-01 0.0735 0.073400 0.003710 6.11e-01 9.80e-01
Mitochondrial iron-sulfur cluster biogenesis 10 8.78e-01 9.14e-01 0.0912 -0.087400 -0.026100 6.32e-01 8.86e-01
Metabolic disorders of biological oxidation enzymes 14 8.79e-01 9.14e-01 0.0803 0.027800 -0.075300 8.57e-01 6.26e-01
Netrin-1 signaling 25 8.79e-01 9.14e-01 0.0607 -0.047600 0.037600 6.80e-01 7.45e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 8.80e-01 9.14e-01 0.0676 -0.066200 -0.014000 6.27e-01 9.18e-01
p75NTR signals via NF-kB 11 8.90e-01 9.23e-01 0.0865 0.042500 -0.075300 8.07e-01 6.66e-01
Pyruvate metabolism 20 8.91e-01 9.23e-01 0.0618 0.004340 0.061600 9.73e-01 6.34e-01
Signaling by ERBB2 in Cancer 12 8.92e-01 9.23e-01 0.0780 -0.023900 -0.074300 8.86e-01 6.56e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 12 8.92e-01 9.23e-01 0.0786 0.013200 0.077500 9.37e-01 6.42e-01
Processing of SMDT1 12 8.96e-01 9.26e-01 0.0794 -0.021700 0.076400 8.97e-01 6.47e-01
Signaling by ERBB2 KD Mutants 11 8.96e-01 9.26e-01 0.0805 -0.079900 -0.009950 6.46e-01 9.54e-01
STING mediated induction of host immune responses 10 9.01e-01 9.29e-01 0.0837 0.083600 -0.003990 6.47e-01 9.83e-01
Miscellaneous transport and binding events 14 9.07e-01 9.35e-01 0.0674 -0.066900 -0.008200 6.65e-01 9.58e-01
RHOBTB2 GTPase cycle 19 9.08e-01 9.35e-01 0.0596 -0.023500 0.054800 8.59e-01 6.79e-01
NRIF signals cell death from the nucleus 14 9.09e-01 9.35e-01 0.0697 0.044700 -0.053500 7.72e-01 7.29e-01
Prefoldin mediated transfer of substrate to CCT/TriC 17 9.10e-01 9.35e-01 0.0588 0.037700 0.045100 7.88e-01 7.48e-01
Association of TriC/CCT with target proteins during biosynthesis 29 9.14e-01 9.39e-01 0.0470 -0.041300 0.022500 7.01e-01 8.34e-01
Regulation of innate immune responses to cytosolic DNA 12 9.17e-01 9.41e-01 0.0716 -0.040000 0.059400 8.10e-01 7.22e-01
Kinesins 31 9.22e-01 9.45e-01 0.0405 0.035400 0.019800 7.34e-01 8.49e-01
FOXO-mediated transcription of cell cycle genes 13 9.22e-01 9.45e-01 0.0648 -0.064300 0.008050 6.88e-01 9.60e-01
RHO GTPases Activate Formins 100 9.31e-01 9.53e-01 0.0222 -0.003880 0.021800 9.47e-01 7.07e-01
Pexophagy 10 9.32e-01 9.54e-01 0.0709 0.052500 -0.047600 7.74e-01 7.94e-01
Non-integrin membrane-ECM interactions 14 9.39e-01 9.60e-01 0.0568 0.036800 -0.043200 8.12e-01 7.80e-01
Long-term potentiation 10 9.42e-01 9.62e-01 0.0645 -0.059900 0.024000 7.43e-01 8.95e-01
Regulation of TNFR1 signaling 30 9.43e-01 9.63e-01 0.0370 -0.016100 0.033300 8.79e-01 7.53e-01
Protein methylation 12 9.46e-01 9.64e-01 0.0572 -0.048800 0.029900 7.70e-01 8.58e-01
Signaling by EGFR in Cancer 16 9.49e-01 9.67e-01 0.0478 0.043600 -0.019400 7.63e-01 8.93e-01
RND1 GTPase cycle 29 9.53e-01 9.70e-01 0.0332 0.001080 0.033200 9.92e-01 7.57e-01
Diseases of mitotic cell cycle 34 9.55e-01 9.71e-01 0.0298 -0.029700 -0.002800 7.65e-01 9.78e-01
TNFR1-induced NFkappaB signaling pathway 19 9.56e-01 9.71e-01 0.0409 -0.036000 0.019500 7.86e-01 8.83e-01
Aggrephagy 18 9.59e-01 9.73e-01 0.0387 0.037500 0.009840 7.83e-01 9.42e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 11 9.59e-01 9.73e-01 0.0504 0.002580 -0.050300 9.88e-01 7.73e-01
Condensation of Prometaphase Chromosomes 10 9.62e-01 9.75e-01 0.0491 0.039200 0.029500 8.30e-01 8.72e-01
SUMOylation of transcription cofactors 35 9.69e-01 9.80e-01 0.0244 0.024200 0.003020 8.04e-01 9.75e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 33 9.69e-01 9.80e-01 0.0254 -0.025100 0.004120 8.03e-01 9.67e-01
Cyclin D associated events in G1 41 9.70e-01 9.80e-01 0.0214 -0.017600 -0.012200 8.46e-01 8.93e-01
G1 Phase 41 9.70e-01 9.80e-01 0.0214 -0.017600 -0.012200 8.46e-01 8.93e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 10 9.82e-01 9.89e-01 0.0363 -0.026600 0.024700 8.84e-01 8.93e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 9.83e-01 9.89e-01 0.0290 -0.028800 0.003440 8.52e-01 9.82e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 9.83e-01 9.89e-01 0.0290 -0.028800 0.003440 8.52e-01 9.82e-01
Constitutive Signaling by EGFRvIII 10 9.84e-01 9.89e-01 0.0325 0.032500 -0.000129 8.59e-01 9.99e-01
Signaling by EGFRvIII in Cancer 10 9.84e-01 9.89e-01 0.0325 0.032500 -0.000129 8.59e-01 9.99e-01
Purine salvage 11 9.86e-01 9.89e-01 0.0288 0.026100 0.012200 8.81e-01 9.44e-01
Complex I biogenesis 43 9.86e-01 9.89e-01 0.0144 0.012700 0.006770 8.86e-01 9.39e-01
Downstream signaling of activated FGFR1 12 9.96e-01 9.96e-01 0.0147 0.001690 -0.014600 9.92e-01 9.30e-01
Downstream signaling of activated FGFR2 12 9.96e-01 9.96e-01 0.0147 0.001690 -0.014600 9.92e-01 9.30e-01
Downstream signaling of activated FGFR3 12 9.96e-01 9.96e-01 0.0147 0.001690 -0.014600 9.92e-01 9.30e-01
Downstream signaling of activated FGFR4 12 9.96e-01 9.96e-01 0.0147 0.001690 -0.014600 9.92e-01 9.30e-01


Detailed Gene set reports


Neutrophil degranulation

Neutrophil degranulation
metric value
setSize 305
pMANOVA 1.84e-43
p.adjustMANOVA 2.14e-40
s.dist 0.473
s.RNA 0.468
s.meth -0.0638
p.RNA 1.56e-44
p.meth 0.0579




Top 20 genes
Gene RNA meth
P2RX1 4678 -1949
UNC13D 4608 -1906
CD300A 4107 -2000
TRPM2 4547 -1794
PYCARD 4218 -1820
CTSZ 3863 -1980
NAPRT 3965 -1871
CYSTM1 4253 -1742
TYROBP 3696 -1997
C3AR1 4621 -1596
ATP6V0A1 4614 -1571
IGF2R 4190 -1659
SLC15A4 4298 -1577
SERPINB1 4518 -1479
MNDA 3329 -1996
QPCT 4310 -1474
AGPAT2 4500 -1388
VAT1 4456 -1359
ARSB 3918 -1528
DNAJC5 4113 -1398

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -532 567
ACAA1 4515 5790
ACLY 4042 2976
ACTR10 2038 4868
ACTR1B -2340 2629
ACTR2 3331 3844
ADAM10 3893 2760
ADAM8 3346 5097
ADGRE5 3345 -1470
AGA -3241 2162
AGL 117 1016
AGPAT2 4500 -1388
ALAD 4163 1057
ALDOA 4405 5367
ALDOC -2180 65
ALOX5 4569 5386
AMPD3 3992 3216
ANO6 1181 1102
AP1M1 3671 1777
APAF1 3293 -809
APEH 1694 832
APRT -3189 2643
ARHGAP9 3724 6257
ARL8A 3929 -1058
ARMC8 1579 2641
ARPC5 3952 2611
ARSA 3137 523
ARSB 3918 -1528
ASAH1 4363 2174
ATAD3B -3596 4811
ATG7 2114 3847
ATP11A 4361 132
ATP11B 3169 -241
ATP6V0A1 4614 -1571
ATP6V0C 4469 2933
ATP6V1D 3887 1096
ATP8A1 -4076 -913
ATP8B4 1802 -1100
B2M -2848 -9
B4GALT1 2813 7043
BIN2 3734 5390
BRI3 4452 -1178
BST2 -279 -1935
C3AR1 4621 -1596
C6orf120 2410 3829
CAB39 3568 7109
CAND1 -2909 2163
CAP1 3857 2034
CAPN1 4234 1819
CAT 3953 -1206
CCT2 -4536 194
CCT8 -1019 2904
CD300A 4107 -2000
CD44 3510 4898
CD47 -4047 6603
CD53 4066 6484
CD55 4431 1455
CD58 3716 -611
CD59 1454 -1684
CD63 4648 5434
CDK13 746 5779
CEACAM1 3407 5459
CEP290 -3496 7002
CKAP4 4379 -987
CMTM6 3361 1926
CNN2 3453 -418
COMMD3 -986 -1962
COMMD9 2550 2239
COPB1 2918 2637
COTL1 4085 6761
CPNE1 -590 5132
CPNE3 1048 -1443
CPPED1 3892 -641
CREG1 3232 -1060
CSNK2B 2032 4743
CSTB 3618 2893
CTSA 4396 2720
CTSB 4601 -965
CTSC 3524 1311
CTSD 4622 6622
CTSS 2262 -1546
CTSZ 3863 -1980
CYB5R3 4351 3239
CYBA 3986 2019
CYFIP1 4146 256
CYSTM1 4253 -1742
DBNL 3790 -406
DEGS1 1101 3203
DERA 3556 3602
DGAT1 1776 -576
DIAPH1 2535 2371
DNAJC13 3848 408
DNAJC3 3801 6472
DNAJC5 4113 -1398
DPP7 -2367 6586
DSN1 -2049 -997
DYNC1H1 590 4434
DYNC1LI1 3051 3242
DYNLL1 521 5151
DYNLT1 2452 5601
EEF1A1 -4394 2941
EEF2 -2501 4196
ENPP4 -108 3170
ERP44 1654 920
FABP5 2875 2233
FAF2 2735 2842
FGR 4634 -1075
FTH1 2431 3117
FTL 3951 -1426
FUCA1 2246 1656
FUCA2 2092 -1236
GAA 3208 2768
GALNS 3403 3670
GCA 4472 5561
GDI2 2462 3343
GGH 2583 3861
GHDC 646 -571
GLB1 4012 1828
GLIPR1 1606 5593
GM2A 4398 6363
GMFG 3602 6369
GNS 4663 4429
GOLGA7 8 3104
GPI 2530 5674
GRN 4392 4938
GSDMD 139 -91
GSTP1 -270 -1352
GUSB 4566 2338
GYG1 4408 -231
HEBP2 3182 552
HEXB 2779 2906
HGSNAT -268 3342
HLA-A -2359 -1094
HLA-B -33 -730
HLA-C 1043 4449
HLA-H -1015 4989
HMGB1 -2719 3222
HMOX2 -3853 6413
HSP90AA1 -1535 6210
HSP90AB1 -4052 -1226
HSPA1A 3554 -920
HSPA1B 3285 655
HVCN1 -90 -385
IDH1 4668 3454
IGF2R 4190 -1659
ILF2 -1669 2770
IMPDH1 4624 2600
IMPDH2 -4586 250
IQGAP1 3914 587
IQGAP2 3127 3888
IST1 3377 1014
ITGAL 1255 7038
ITGAV 2851 -370
ITGB2 4401 6426
KCMF1 3111 3310
KCNAB2 2208 -600
KPNB1 1929 1140
LAIR1 4611 3425
LAMP1 3730 2553
LAMTOR1 3516 -1589
LAMTOR2 2924 -1342
LAMTOR3 1845 957
LPCAT1 2780 1418
LTA4H 4219 798
MAN2B1 1986 6389
MANBA 2776 6846
MAPK1 4578 6099
MAPK14 4535 2465
MIF -2932 3355
MLEC 281 2183
MMP25 4503 6854
MNDA 3329 -1996
MPO -3556 -1969
MVP 3196 6955
NAPRT 3965 -1871
NBEAL2 4333 1726
NCKAP1L 4625 -320
NCSTN 4682 1224
NDUFC2 2060 2881
NEU1 4519 1899
NHLRC3 1715 4506
NIT2 -4039 -141
NME2 -284 -880
NPC2 1157 2198
ORMDL3 -2451 3085
OSCAR 4669 7123
OSTF1 3075 6470
P2RX1 4678 -1949
PA2G4 -2025 5243
PAFAH1B2 2082 2435
PDAP1 3390 2952
PDXK 3046 1492
PFKL -1324 -1732
PGAM1 4544 1307
PGM1 2586 776
PGM2 4121 5134
PKM 4204 3231
PLAC8 4540 1235
PLAU 1336 -1529
PLAUR 4189 -861
PLD1 4524 -902
PLEKHO2 4499 6699
PNP 2941 3516
PPIA -2610 4555
PPIE -2531 6027
PRCP 3166 611
PRDX6 1745 5478
PRKCD 4562 6360
PRTN3 -4157 5621
PSAP 3330 628
PSEN1 4153 4955
PSMA2 -1044 5164
PSMA5 -3128 3319
PSMB1 -1362 5410
PSMB7 3139 4199
PSMC3 319 736
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD6 2617 2336
PSMD7 735 2079
PTGES2 -2116 -901
PTPN6 4161 6542
PTPRC 2931 -936
PTPRJ 4090 7170
PTPRN2 1668 6585
PYCARD 4218 -1820
PYGB -154 141
QPCT 4310 -1474
QSOX1 4653 5727
RAB10 4448 3067
RAB14 1884 -378
RAB18 2497 2764
RAB24 3694 -168
RAB27A 3688 222
RAB37 -373 409
RAB3A 2176 4348
RAB3D 4294 1148
RAB4B 3134 4688
RAB5B 3040 1957
RAB5C 3819 797
RAB6A 3874 3323
RAB7A 3957 -124
RAC1 4263 5541
RAP1A 2631 6569
RAP1B 2468 5968
RAP2B 1340 5292
RHOA 3580 4033
RHOF -3792 6478
RHOG 4271 3664
RNASET2 2898 7090
ROCK1 3235 2732
S100A11 4428 6089
S100P 3846 3303
SCAMP1 -3040 2645
SDCBP 3866 3834
SERPINB1 4518 -1479
SERPINB6 1810 2823
SLC11A1 4685 4001
SLC15A4 4298 -1577
SLC27A2 -2500 -1411
SLC2A3 4316 -1211
SLC44A2 1778 4323
SLCO4C1 3151 -99
SNAP23 2713 -471
SNAP29 3459 3148
SPTAN1 -4222 -407
SRP14 1720 5764
STBD1 1952 -658
STK10 3375 -688
STK11IP 3318 2122
STOM 2913 -1586
SURF4 3061 3679
SVIP -1140 1104
TBC1D10C -3207 6912
TCIRG1 4550 1353
TLR2 4215 4128
TMBIM1 4002 -47
TMC6 -2639 6750
TMEM179B -609 5597
TMEM30A 2493 6660
TMEM63A -3402 2620
TNFRSF1B 3940 6870
TOLLIP 3713 664
TOM1 4248 4280
TRAPPC1 3425 5233
TRPM2 4547 -1794
TSPAN14 4341 4963
TUBB -611 6248
TUBB4B 3129 7163
TXNDC5 -784 -1873
TYROBP 3696 -1997
UNC13D 4608 -1906
VAMP8 -46 868
VAPA 3695 4246
VAT1 4456 -1359
VCL 2144 3614
VCP 2829 1908
XRCC5 637 1327
XRCC6 -3489 3282
YPEL5 2611 3986



Innate Immune System

Innate Immune System
metric value
setSize 616
pMANOVA 3.63e-39
p.adjustMANOVA 2.11e-36
s.dist 0.318
s.RNA 0.318
s.meth 0.000995
p.RNA 3.6e-40
p.meth 0.967




Top 20 genes
Gene RNA meth
OSCAR 4669 7123
ATP6V0D1 4480 6936
MMP25 4503 6854
CTSD 4622 6622
RIPK3 4479 6795
PLEKHO2 4499 6699
MYO9B 4389 6777
PTPRJ 4090 7170
PRKCD 4562 6360
ITGB2 4401 6426
GM2A 4398 6363
MAPK1 4578 6099
COTL1 4085 6761
PTPN6 4161 6542
CRK 4125 6598
TNFRSF1B 3940 6870
GRB2 4326 6241
S100A11 4428 6089
QSOX1 4653 5727
CD53 4066 6484

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -532 567
AAMP -2521 7121
ABI1 3566 3253
ABI2 -3506 -206
ABL1 2124 2469
ACAA1 4515 5790
ACLY 4042 2976
ACTB 4254 5447
ACTG1 3711 1603
ACTR10 2038 4868
ACTR1B -2340 2629
ACTR2 3331 3844
ACTR3 3319 5952
ADAM10 3893 2760
ADAM8 3346 5097
ADGRE5 3345 -1470
AGA -3241 2162
AGL 117 1016
AGPAT2 4500 -1388
AHCYL1 2529 2692
AIM2 -217 -1277
ALAD 4163 1057
ALDOA 4405 5367
ALDOC -2180 65
ALOX5 4569 5386
AMPD3 3992 3216
ANO6 1181 1102
AP1M1 3671 1777
APAF1 3293 -809
APEH 1694 832
APP 2164 6623
APRT -3189 2643
ARHGAP9 3724 6257
ARL8A 3929 -1058
ARMC8 1579 2641
ARPC1B 4355 1709
ARPC2 3393 2292
ARPC3 3253 3208
ARPC5 3952 2611
ARSA 3137 523
ARSB 3918 -1528
ASAH1 4363 2174
ATAD3B -3596 4811
ATF1 901 2989
ATG12 -2319 6823
ATG5 -1248 -680
ATG7 2114 3847
ATOX1 2267 390
ATP11A 4361 132
ATP11B 3169 -241
ATP6V0A1 4614 -1571
ATP6V0A2 -2659 6653
ATP6V0B 3770 5503
ATP6V0C 4469 2933
ATP6V0D1 4480 6936
ATP6V0E1 3116 1836
ATP6V0E2 -4219 -1327
ATP6V1A 3646 -1497
ATP6V1B2 3599 -1555
ATP6V1C1 3836 6759
ATP6V1D 3887 1096
ATP6V1E1 3016 4776
ATP6V1F 1310 -699
ATP6V1G2 -4032 3740
ATP6V1H 2526 2559
ATP8A1 -4076 -913
ATP8B4 1802 -1100
B2M -2848 -9
B4GALT1 2813 7043
BAIAP2 -676 2757
BCL10 2656 2575
BCL2 -2865 7022
BCL2L1 1700 5970
BIN2 3734 5390
BIRC2 954 6626
BIRC3 -4544 4817
BRI3 4452 -1178
BRK1 -951 3071
BST2 -279 -1935
BTRC -1609 -923
C3AR1 4621 -1596
C6orf120 2410 3829
C8G -1370 -1366
CAB39 3568 7109
CALM1 -444 4502
CAND1 -2909 2163
CAP1 3857 2034
CAPN1 4234 1819
CAPZA1 3644 999
CAPZA2 3025 4667
CARD11 -3815 6544
CARD9 2821 -1763
CASP1 1025 7031
CASP10 347 -1807
CASP4 2411 -96
CASP8 -1853 5448
CASP9 4573 3202
CAT 3953 -1206
CCT2 -4536 194
CCT8 -1019 2904
CD247 -3828 6036
CD300A 4107 -2000
CD4 -2816 909
CD44 3510 4898
CD46 2283 5540
CD47 -4047 6603
CD53 4066 6484
CD55 4431 1455
CD58 3716 -611
CD59 1454 -1684
CD63 4648 5434
CD81 -1371 3296
CDC34 3802 -408
CDC42 3077 856
CDK13 746 5779
CEACAM1 3407 5459
CEP290 -3496 7002
CFL1 3776 1646
CHUK 3252 1111
CKAP4 4379 -987
CMTM6 3361 1926
CNN2 3453 -418
CNPY3 2729 1242
COMMD3 -986 -1962
COMMD9 2550 2239
COPB1 2918 2637
COTL1 4085 6761
CPNE1 -590 5132
CPNE3 1048 -1443
CPPED1 3892 -641
CRCP 2587 4708
CREB1 -1515 1422
CREBBP 2992 892
CREG1 3232 -1060
CRK 4125 6598
CSNK2B 2032 4743
CSTB 3618 2893
CTNNB1 3708 5070
CTSA 4396 2720
CTSB 4601 -965
CTSC 3524 1311
CTSD 4622 6622
CTSL 4053 3028
CTSS 2262 -1546
CTSV -1434 5170
CTSZ 3863 -1980
CUL1 -4198 -1192
CYB5R3 4351 3239
CYBA 3986 2019
CYFIP1 4146 256
CYFIP2 -275 6159
CYLD -4500 5706
CYSTM1 4253 -1742
DBNL 3790 -406
DDX41 844 4426
DDX58 -3149 185
DEGS1 1101 3203
DERA 3556 3602
DGAT1 1776 -576
DHX36 -1604 6440
DHX58 -1478 -30
DHX9 -1435 5547
DIAPH1 2535 2371
DNAJC13 3848 408
DNAJC3 3801 6472
DNAJC5 4113 -1398
DNM1 2083 1607
DNM2 4115 3063
DPP7 -2367 6586
DSN1 -2049 -997
DTX4 3444 5144
DUSP3 3162 2260
DUSP4 -775 2494
DUSP6 -1141 -1943
DUSP7 -914 722
DYNC1H1 590 4434
DYNC1LI1 3051 3242
DYNLL1 521 5151
DYNLT1 2452 5601
ECSIT 807 1450
EEA1 -61 5335
EEF1A1 -4394 2941
EEF2 -2501 4196
ELMO1 1879 939
ELMO2 3996 6110
ENPP4 -108 3170
EP300 3773 4901
ERP44 1654 920
FABP5 2875 2233
FADD 3278 -329
FAF2 2735 2842
FBXW11 1937 -1508
FGR 4634 -1075
FOS 989 5647
FTH1 2431 3117
FTL 3951 -1426
FUCA1 2246 1656
FUCA2 2092 -1236
FYN -2007 2793
GAA 3208 2768
GAB2 4209 2390
GALNS 3403 3670
GCA 4472 5561
GDI2 2462 3343
GGH 2583 3861
GHDC 646 -571
GLB1 4012 1828
GLIPR1 1606 5593
GM2A 4398 6363
GMFG 3602 6369
GNS 4663 4429
GOLGA7 8 3104
GPI 2530 5674
GRAP2 -764 3631
GRB2 4326 6241
GRN 4392 4938
GSDMD 139 -91
GSTP1 -270 -1352
GUSB 4566 2338
GYG1 4408 -231
GZMM -2959 7252
HEBP2 3182 552
HERC5 -2754 -1038
HEXB 2779 2906
HGSNAT -268 3342
HLA-A -2359 -1094
HLA-B -33 -730
HLA-C 1043 4449
HLA-E 727 5636
HLA-H -1015 4989
HMGB1 -2719 3222
HMOX2 -3853 6413
HRAS -2033 -823
HSP90AA1 -1535 6210
HSP90AB1 -4052 -1226
HSP90B1 -644 2127
HSPA1A 3554 -920
HSPA1B 3285 655
HVCN1 -90 -385
ICAM2 -4296 4819
ICAM3 2146 6840
IDH1 4668 3454
IFIH1 -3138 2681
IGF2R 4190 -1659
IKBKB 612 -912
IKBKE 3043 6705
ILF2 -1669 2770
IMPDH1 4624 2600
IMPDH2 -4586 250
IQGAP1 3914 587
IQGAP2 3127 3888
IRAK2 -1035 4686
IRAK3 4427 666
IRF3 -2733 4241
IRF7 1413 3556
ISG15 -1955 6541
IST1 3377 1014
ITCH 2375 4854
ITGAL 1255 7038
ITGAV 2851 -370
ITGB2 4401 6426
ITK -4345 -1701
ITPR1 -1390 1789
ITPR2 2788 -44
ITPR3 -2430 2189
JUN 1097 1283
KCMF1 3111 3310
KCNAB2 2208 -600
KPNB1 1929 1140
KRAS 2127 3139
LAIR1 4611 3425
LAMP1 3730 2553
LAMTOR1 3516 -1589
LAMTOR2 2924 -1342
LAMTOR3 1845 957
LAT2 4284 -1716
LCK -4275 7246
LCP2 1292 -428
LGMN -3257 2706
LIMK1 2952 -1750
LPCAT1 2780 1418
LRRFIP1 3283 5297
LTA4H 4219 798
MALT1 -4548 2545
MAN2B1 1986 6389
MANBA 2776 6846
MAP2K1 3972 1533
MAP2K3 4118 2411
MAP2K4 2808 4764
MAP2K6 4449 4792
MAP2K7 529 1764
MAP3K1 2177 2247
MAP3K14 -3760 4221
MAP3K7 1384 -147
MAP3K8 4618 3266
MAPK1 4578 6099
MAPK14 4535 2465
MAPK3 3753 1978
MAPK7 3913 -244
MAPK8 -3916 4554
MAPK9 -2113 157
MAPKAPK2 3308 3265
MAPKAPK3 4600 2896
MAVS 2983 4281
MEF2A 3832 3013
MIF -2932 3355
MLEC 281 2183
MMP25 4503 6854
MNDA 3329 -1996
MPO -3556 -1969
MUC1 1530 6715
MUC12 -670 4641
MUC5B 2214 -1745
MVP 3196 6955
MYD88 4639 1945
MYH9 3495 6146
MYO9B 4389 6777
NAPRT 3965 -1871
NBEAL2 4333 1726
NCF4 4375 -1941
NCK1 -3937 1018
NCKAP1L 4625 -320
NCKIPSD -1401 667
NCSTN 4682 1224
NDUFC2 2060 2881
NEU1 4519 1899
NF2 1417 1410
NFATC1 -2446 6947
NFATC2 -3694 7159
NFATC3 -2698 1668
NFKB2 -1330 5251
NFKBIA 1880 6814
NFKBIB 2414 5574
NHLRC3 1715 4506
NIT2 -4039 -141
NKIRAS1 -2478 348
NKIRAS2 4516 -1132
NLRC5 -511 1905
NLRP1 -1865 3033
NLRP3 3356 -847
NLRX1 4376 768
NME2 -284 -880
NOD1 -1381 -321
NOD2 3888 6610
NOS3 -2969 4048
NPC2 1157 2198
ORMDL3 -2451 3085
OSCAR 4669 7123
OSTF1 3075 6470
P2RX1 4678 -1949
PA2G4 -2025 5243
PAFAH1B2 2082 2435
PAK1 3920 2452
PAK2 3401 283
PANX1 3037 3960
PCBP2 90 3201
PDAP1 3390 2952
PDPK1 3242 346
PDXK 3046 1492
PELI1 1650 1867
PELI2 2137 7035
PELI3 3441 -1123
PFKL -1324 -1732
PGAM1 4544 1307
PGM1 2586 776
PGM2 4121 5134
PIK3CA 749 1470
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R4 -767 2170
PIN1 214 4014
PKM 4204 3231
PLA2G6 -2968 826
PLAC8 4540 1235
PLAU 1336 -1529
PLAUR 4189 -861
PLCG1 -4193 958
PLCG2 4027 2803
PLD1 4524 -902
PLD3 2198 354
PLEKHO2 4499 6699
PNP 2941 3516
POLR1C -4031 5329
POLR1D 589 6782
POLR2E 1754 3712
POLR2F 1457 509
POLR2H -2461 6299
POLR2K -1891 3853
POLR3A 1126 5226
POLR3C -1707 3978
POLR3D -3951 1967
POLR3E -3745 1113
POLR3F -3279 -1023
POLR3G -2957 6661
POLR3GL -987 204
POLR3H -4357 5546
POLR3K -734 891
PPIA -2610 4555
PPIE -2531 6027
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5D 2308 3470
PPP3CA 1228 5980
PPP3CB 2123 4044
PPP3R1 1915 2945
PRCP 3166 611
PRDX6 1745 5478
PRKACA 4651 890
PRKACB -4452 1712
PRKCD 4562 6360
PRKCE 3011 -1185
PRKCQ -4200 4208
PRKCSH 2404 4698
PRKDC -1555 6476
PRTN3 -4157 5621
PSAP 3330 628
PSEN1 4153 4955
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
PSTPIP1 4165 680
PTGES2 -2116 -901
PTK2 147 -475
PTPN11 2272 5062
PTPN4 -3616 784
PTPN6 4161 6542
PTPRC 2931 -936
PTPRJ 4090 7170
PTPRN2 1668 6585
PYCARD 4218 -1820
PYGB -154 141
QPCT 4310 -1474
QSOX1 4653 5727
RAB10 4448 3067
RAB14 1884 -378
RAB18 2497 2764
RAB24 3694 -168
RAB27A 3688 222
RAB37 -373 409
RAB3A 2176 4348
RAB3D 4294 1148
RAB4B 3134 4688
RAB5B 3040 1957
RAB5C 3819 797
RAB6A 3874 3323
RAB7A 3957 -124
RAC1 4263 5541
RAC2 3032 4577
RAF1 3715 6573
RAP1A 2631 6569
RAP1B 2468 5968
RAP2B 1340 5292
RASGRP1 -4180 5888
RASGRP2 -2424 -413
RBSN 404 6354
RELA -73 4333
RELB 824 577
RHOA 3580 4033
RHOF -3792 6478
RHOG 4271 3664
RIPK3 4479 6795
RNASET2 2898 7090
RNF125 -4414 6176
RNF135 4467 -1615
RNF216 -2878 4491
ROCK1 3235 2732
RPS27A -4373 2589
RPS6KA1 4529 -1859
RPS6KA2 1506 2117
RPS6KA5 -4174 1991
S100A11 4428 6089
S100P 3846 3303
SARM1 -3567 4842
SCAMP1 -3040 2645
SDCBP 3866 3834
SERPINB1 4518 -1479
SERPINB6 1810 2823
SHC1 3650 3205
SIGIRR -2791 6807
SIKE1 -1946 1675
SKP1 -2513 2680
SLC11A1 4685 4001
SLC15A4 4298 -1577
SLC27A2 -2500 -1411
SLC2A3 4316 -1211
SLC44A2 1778 4323
SLCO4C1 3151 -99
SNAP23 2713 -471
SNAP29 3459 3148
SOCS1 1609 4130
SOS1 -1111 -1986
SPTAN1 -4222 -407
SRC -2558 -1476
SRP14 1720 5764
STAT6 3810 3854
STBD1 1952 -658
STK10 3375 -688
STK11IP 3318 2122
STOM 2913 -1586
SUGT1 -1217 5005
SURF4 3061 3679
SVIP -1140 1104
SYK 4033 431
TAB2 693 6401
TANK 3188 6239
TAX1BP1 1803 1037
TBC1D10C -3207 6912
TBK1 1669 599
TCIRG1 4550 1353
TEC 3772 170
TICAM1 3321 1060
TIFA -537 4848
TIRAP 3312 1661
TLR1 3931 -1113
TLR2 4215 4128
TLR3 -3090 2949
TLR5 4577 5701
TLR6 3415 -1201
TLR9 -10 7204
TMBIM1 4002 -47
TMC6 -2639 6750
TMEM179B -609 5597
TMEM30A 2493 6660
TMEM63A -3402 2620
TNFAIP3 -842 6105
TNFRSF1B 3940 6870
TNIP2 2832 287
TOLLIP 3713 664
TOM1 4248 4280
TRAF2 -3119 5765
TRAF3 -3164 7209
TRAF6 1605 -71
TRAPPC1 3425 5233
TREX1 55 -1436
TRIM21 1631 -1673
TRIM25 4522 446
TRIM56 -1054 5740
TRPM2 4547 -1794
TSPAN14 4341 4963
TUBB -611 6248
TUBB4B 3129 7163
TXK -4318 4860
TXN 3518 -1735
TXNDC5 -784 -1873
TXNIP -1950 6154
TYROBP 3696 -1997
UBA3 2802 4052
UBA52 -1313 -69
UBA7 -1131 -1591
UBB 355 5059
UBC 2129 3220
UBE2D1 3526 2741
UBE2D2 -290 2134
UBE2D3 3214 3005
UBE2K 1774 3260
UBE2L6 -3276 1295
UBE2M 2658 2052
UBE2N -757 4834
UBE2V1 -446 2792
UNC13D 4608 -1906
UNC93B1 4207 4749
VAMP8 -46 868
VAPA 3695 4246
VAT1 4456 -1359
VAV1 4015 5834
VAV2 975 4134
VAV3 3114 -685
VCL 2144 3614
VCP 2829 1908
VRK3 2567 2903
VTN 610 -1927
WASF1 4637 -830
WASF2 4371 -134
WASL 1150 4645
WIPF1 1102 -784
WIPF2 3237 -1018
XRCC5 637 1327
XRCC6 -3489 3282
YES1 -1057 5198
YPEL5 2611 3986
ZBP1 -2358 7177



rRNA processing

rRNA processing
metric value
setSize 159
pMANOVA 2.24e-36
p.adjustMANOVA 8.68e-34
s.dist 0.596
s.RNA -0.584
s.meth 0.123
p.RNA 6.59e-37
p.meth 0.00786




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
TSR1 -4374 6839
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
SNU13 -3683 7054
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
EXOSC2 -4396 5344
RPL13A -4186 5523
WDR43 -4181 5510
NOP2 -3578 6403
RPS16 -3735 5981
PNO1 -3412 6496
RPP25 -3799 5745

Click HERE to show all gene set members

All member genes
RNA meth
BMS1 -4317 -1755
BYSL -1886 6808
C1D -117 2322
CSNK1D 3147 3046
CSNK1E -2625 3000
DCAF13 -3178 862
DDX21 -423 3312
DDX47 -4147 -50
DDX49 1400 5582
DDX52 621 -204
DHX37 -1827 4195
DIS3 -1584 -754
EBNA1BP2 -3371 6235
ELAC2 -2081 275
ERI1 2342 -139
EXOSC1 -183 316
EXOSC10 -2785 802
EXOSC2 -4396 5344
EXOSC3 -12 3245
EXOSC4 3917 64
EXOSC5 -3620 790
EXOSC6 -3115 1534
EXOSC7 -3669 -158
EXOSC8 -4171 1364
FAU -1368 6877
FBL -4488 -43
FCF1 169 6763
FTSJ3 -424 4236
GAR1 -3086 879
GNL3 -4499 1201
HEATR1 -3022 5201
IMP3 -2832 5542
IMP4 -2963 3786
ISG20L2 1107 6438
KRR1 -3265 -1952
LTV1 -2942 2915
MPHOSPH10 -3876 5401
MPHOSPH6 -1196 5535
MRM1 -3703 -159
MTERF4 -4478 3503
NCL -4149 5054
NHP2 -2631 4827
NIP7 -3295 4219
NOB1 -3907 2003
NOC4L 554 -799
NOL11 -4484 2571
NOL12 1466 -1551
NOL6 -3321 4557
NOL9 -3852 -1446
NOP10 4120 2081
NOP14 -4322 2209
NOP2 -3578 6403
NOP56 -4212 996
NOP58 -4541 1333
NSUN4 811 3316
PDCD11 -2635 3455
PELP1 -3537 2742
PES1 -2958 3288
PNO1 -3412 6496
PWP2 -2097 5076
RBM28 -2232 3412
RCL1 -3250 6343
RIOK1 -1870 6498
RIOK2 -3453 1638
RIOK3 2518 3472
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPP14 -809 2236
RPP21 -1630 2599
RPP25 -3799 5745
RPP30 -3771 668
RPP38 -3246 4780
RPP40 -4559 570
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
RRP1 -1139 5200
RRP7A -2020 1582
RRP9 -3748 653
SENP3 36 5394
SNU13 -3683 7054
TBL3 262 5418
TEX10 -3909 1204
TFB1M -2804 1831
THUMPD1 -4407 -871
TRMT112 -847 1929
TSR1 -4374 6839
TSR3 505 6370
UBA52 -1313 -69
UTP15 -4042 5063
UTP18 1320 3357
UTP20 -3101 5085
UTP3 -1850 3926
UTP6 -3759 3932
WDR12 -266 6794
WDR18 -1452 -1078
WDR3 -2885 -1387
WDR36 -1954 6601
WDR43 -4181 5510
WDR75 -4429 4614
XRN2 4041 -29



rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol
metric value
setSize 154
pMANOVA 1.52e-35
p.adjustMANOVA 4.42e-33
s.dist 0.6
s.RNA -0.585
s.meth 0.133
p.RNA 6.49e-36
p.meth 0.00459




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
TSR1 -4374 6839
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
SNU13 -3683 7054
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
EXOSC2 -4396 5344
RPL13A -4186 5523
WDR43 -4181 5510
NOP2 -3578 6403
RPS16 -3735 5981
PNO1 -3412 6496
RPP25 -3799 5745

Click HERE to show all gene set members

All member genes
RNA meth
BMS1 -4317 -1755
BYSL -1886 6808
C1D -117 2322
CSNK1D 3147 3046
CSNK1E -2625 3000
DCAF13 -3178 862
DDX21 -423 3312
DDX47 -4147 -50
DDX49 1400 5582
DDX52 621 -204
DHX37 -1827 4195
DIS3 -1584 -754
EBNA1BP2 -3371 6235
ERI1 2342 -139
EXOSC1 -183 316
EXOSC10 -2785 802
EXOSC2 -4396 5344
EXOSC3 -12 3245
EXOSC4 3917 64
EXOSC5 -3620 790
EXOSC6 -3115 1534
EXOSC7 -3669 -158
EXOSC8 -4171 1364
FAU -1368 6877
FBL -4488 -43
FCF1 169 6763
FTSJ3 -424 4236
GAR1 -3086 879
GNL3 -4499 1201
HEATR1 -3022 5201
IMP3 -2832 5542
IMP4 -2963 3786
ISG20L2 1107 6438
KRR1 -3265 -1952
LTV1 -2942 2915
MPHOSPH10 -3876 5401
MPHOSPH6 -1196 5535
NCL -4149 5054
NHP2 -2631 4827
NIP7 -3295 4219
NOB1 -3907 2003
NOC4L 554 -799
NOL11 -4484 2571
NOL12 1466 -1551
NOL6 -3321 4557
NOL9 -3852 -1446
NOP10 4120 2081
NOP14 -4322 2209
NOP2 -3578 6403
NOP56 -4212 996
NOP58 -4541 1333
PDCD11 -2635 3455
PELP1 -3537 2742
PES1 -2958 3288
PNO1 -3412 6496
PWP2 -2097 5076
RBM28 -2232 3412
RCL1 -3250 6343
RIOK1 -1870 6498
RIOK2 -3453 1638
RIOK3 2518 3472
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPP14 -809 2236
RPP21 -1630 2599
RPP25 -3799 5745
RPP30 -3771 668
RPP38 -3246 4780
RPP40 -4559 570
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
RRP1 -1139 5200
RRP7A -2020 1582
RRP9 -3748 653
SENP3 36 5394
SNU13 -3683 7054
TBL3 262 5418
TEX10 -3909 1204
THUMPD1 -4407 -871
TRMT112 -847 1929
TSR1 -4374 6839
TSR3 505 6370
UBA52 -1313 -69
UTP15 -4042 5063
UTP18 1320 3357
UTP20 -3101 5085
UTP3 -1850 3926
UTP6 -3759 3932
WDR12 -266 6794
WDR18 -1452 -1078
WDR3 -2885 -1387
WDR36 -1954 6601
WDR43 -4181 5510
WDR75 -4429 4614
XRN2 4041 -29



Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol
metric value
setSize 147
pMANOVA 2.33e-35
p.adjustMANOVA 5.4e-33
s.dist 0.612
s.RNA -0.597
s.meth 0.135
p.RNA 9.38e-36
p.meth 0.00505




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
TSR1 -4374 6839
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
SNU13 -3683 7054
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
EXOSC2 -4396 5344
RPL13A -4186 5523
WDR43 -4181 5510
RPS16 -3735 5981
PNO1 -3412 6496
RPP25 -3799 5745
RPS29 -3769 5602

Click HERE to show all gene set members

All member genes
RNA meth
BMS1 -4317 -1755
BYSL -1886 6808
C1D -117 2322
CSNK1D 3147 3046
CSNK1E -2625 3000
DCAF13 -3178 862
DDX21 -423 3312
DDX47 -4147 -50
DDX49 1400 5582
DDX52 621 -204
DHX37 -1827 4195
DIS3 -1584 -754
EBNA1BP2 -3371 6235
ERI1 2342 -139
EXOSC1 -183 316
EXOSC10 -2785 802
EXOSC2 -4396 5344
EXOSC3 -12 3245
EXOSC4 3917 64
EXOSC5 -3620 790
EXOSC6 -3115 1534
EXOSC7 -3669 -158
EXOSC8 -4171 1364
FAU -1368 6877
FBL -4488 -43
FCF1 169 6763
FTSJ3 -424 4236
GNL3 -4499 1201
HEATR1 -3022 5201
IMP3 -2832 5542
IMP4 -2963 3786
ISG20L2 1107 6438
KRR1 -3265 -1952
LTV1 -2942 2915
MPHOSPH10 -3876 5401
MPHOSPH6 -1196 5535
NCL -4149 5054
NIP7 -3295 4219
NOB1 -3907 2003
NOC4L 554 -799
NOL11 -4484 2571
NOL12 1466 -1551
NOL6 -3321 4557
NOL9 -3852 -1446
NOP14 -4322 2209
NOP56 -4212 996
NOP58 -4541 1333
PDCD11 -2635 3455
PELP1 -3537 2742
PES1 -2958 3288
PNO1 -3412 6496
PWP2 -2097 5076
RBM28 -2232 3412
RCL1 -3250 6343
RIOK1 -1870 6498
RIOK2 -3453 1638
RIOK3 2518 3472
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPP14 -809 2236
RPP21 -1630 2599
RPP25 -3799 5745
RPP30 -3771 668
RPP38 -3246 4780
RPP40 -4559 570
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
RRP1 -1139 5200
RRP7A -2020 1582
RRP9 -3748 653
SENP3 36 5394
SNU13 -3683 7054
TBL3 262 5418
TEX10 -3909 1204
TSR1 -4374 6839
UBA52 -1313 -69
UTP15 -4042 5063
UTP18 1320 3357
UTP20 -3101 5085
UTP3 -1850 3926
UTP6 -3759 3932
WDR12 -266 6794
WDR18 -1452 -1078
WDR3 -2885 -1387
WDR36 -1954 6601
WDR43 -4181 5510
WDR75 -4429 4614
XRN2 4041 -29



Immune System

Immune System
metric value
setSize 1142
pMANOVA 8.47e-34
p.adjustMANOVA 1.64e-31
s.dist 0.221
s.RNA 0.218
s.meth 0.0349
p.RNA 2.87e-33
p.meth 0.0558




Top 20 genes
Gene RNA meth
OSCAR 4669 7123
ATP6V0D1 4480 6936
MMP25 4503 6854
CTSD 4622 6622
RIPK3 4479 6795
PLEKHO2 4499 6699
SLA 4302 6986
MYO9B 4389 6777
CLTC 4062 7259
PTPRJ 4090 7170
KLHL2 4557 6411
PRKCD 4562 6360
STIM1 3982 7265
SOCS3 4385 6492
ITGB2 4401 6426
GM2A 4398 6363
MAPK1 4578 6099
COTL1 4085 6761
PTPN9 4514 6096
TRIM8 4311 6375

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -532 567
AAAS -1256 1467
AAMP -2521 7121
ABCE1 -4561 6006
ABI1 3566 3253
ABI2 -3506 -206
ABL1 2124 2469
ABL2 1414 5308
ACAA1 4515 5790
ACLY 4042 2976
ACTB 4254 5447
ACTG1 3711 1603
ACTR10 2038 4868
ACTR1A 4067 1932
ACTR1B -2340 2629
ACTR2 3331 3844
ACTR3 3319 5952
ADAM10 3893 2760
ADAM17 4453 4155
ADAM8 3346 5097
ADAR 2571 3087
ADGRE5 3345 -1470
AGA -3241 2162
AGL 117 1016
AGPAT2 4500 -1388
AHCYL1 2529 2692
AIM2 -217 -1277
AIP -518 6684
AKT1 2261 1109
AKT2 1896 5431
ALAD 4163 1057
ALDOA 4405 5367
ALDOC -2180 65
ALOX5 4569 5386
AMPD3 3992 3216
ANAPC1 -4431 2990
ANAPC10 -653 -1326
ANAPC11 1335 3188
ANAPC13 -2109 493
ANAPC2 -1459 2865
ANAPC4 -998 -687
ANAPC5 -3133 5213
ANAPC7 182 1873
ANO6 1181 1102
AP1B1 4407 5783
AP1G1 2623 2214
AP1M1 3671 1777
AP1S3 -678 1942
AP2A1 4643 -316
AP2M1 3281 3723
AP2S1 2943 6039
APAF1 3293 -809
APEH 1694 832
APP 2164 6623
APRT -3189 2643
AREL1 4233 5153
ARF1 4256 -1821
ARHGAP9 3724 6257
ARIH1 373 3751
ARIH2 -3381 3734
ARL8A 3929 -1058
ARMC8 1579 2641
ARPC1B 4355 1709
ARPC2 3393 2292
ARPC3 3253 3208
ARPC5 3952 2611
ARSA 3137 523
ARSB 3918 -1528
ASAH1 4363 2174
ASB1 4092 6031
ASB13 -214 1754
ASB2 -1847 6213
ASB6 1718 -1069
ASB7 858 6529
ASB8 2042 5453
ATAD3B -3596 4811
ATF1 901 2989
ATG12 -2319 6823
ATG5 -1248 -680
ATG7 2114 3847
ATOX1 2267 390
ATP11A 4361 132
ATP11B 3169 -241
ATP6V0A1 4614 -1571
ATP6V0A2 -2659 6653
ATP6V0B 3770 5503
ATP6V0C 4469 2933
ATP6V0D1 4480 6936
ATP6V0E1 3116 1836
ATP6V0E2 -4219 -1327
ATP6V1A 3646 -1497
ATP6V1B2 3599 -1555
ATP6V1C1 3836 6759
ATP6V1D 3887 1096
ATP6V1E1 3016 4776
ATP6V1F 1310 -699
ATP6V1G2 -4032 3740
ATP6V1H 2526 2559
ATP8A1 -4076 -913
ATP8B4 1802 -1100
B2M -2848 -9
B4GALT1 2813 7043
BAIAP2 -676 2757
BATF 1388 6679
BCL10 2656 2575
BCL2 -2865 7022
BCL2L1 1700 5970
BCL2L11 3454 5664
BCL6 4635 3669
BIN2 3734 5390
BIRC2 954 6626
BIRC3 -4544 4817
BIRC5 1558 1965
BLMH -843 -120
BRI3 4452 -1178
BRK1 -951 3071
BRWD1 -2281 -349
BST2 -279 -1935
BTBD1 -1017 120
BTBD6 -2048 3006
BTN2A1 415 1617
BTN2A2 -3458 108
BTN3A1 -2926 1278
BTN3A2 -4412 3317
BTN3A3 -3948 6404
BTRC -1609 -923
C3AR1 4621 -1596
C6orf120 2410 3829
C8G -1370 -1366
CAB39 3568 7109
CALM1 -444 4502
CALR 2787 5714
CAMK2D -4472 -529
CAMK2G 891 6718
CAND1 -2909 2163
CANX 1159 3479
CAP1 3857 2034
CAPN1 4234 1819
CAPZA1 3644 999
CAPZA2 3025 4667
CAPZB 3664 -308
CARD11 -3815 6544
CARD9 2821 -1763
CASP1 1025 7031
CASP10 347 -1807
CASP3 1520 5691
CASP4 2411 -96
CASP8 -1853 5448
CASP9 4573 3202
CAT 3953 -1206
CBL 3838 1012
CBLB -3632 343
CCND1 -1449 1006
CCNF -508 392
CCR1 3634 -1921
CCT2 -4536 194
CCT8 -1019 2904
CD247 -3828 6036
CD274 -3361 -305
CD300A 4107 -2000
CD3D -3572 7274
CD3E -4097 7193
CD4 -2816 909
CD44 3510 4898
CD46 2283 5540
CD47 -4047 6603
CD53 4066 6484
CD55 4431 1455
CD58 3716 -611
CD59 1454 -1684
CD63 4648 5434
CD74 -3590 -648
CD79B -3447 -1167
CD81 -1371 3296
CD96 -4554 6878
CDC16 -1567 3340
CDC20 1603 2639
CDC23 -3790 1597
CDC34 3802 -408
CDC42 3077 856
CDK13 746 5779
CDKN1A 1908 2427
CDKN1B -1167 3367
CEACAM1 3407 5459
CEBPD 4221 -907
CENPE 2054 -74
CEP290 -3496 7002
CFL1 3776 1646
CHUK 3252 1111
CISH -175 4928
CKAP4 4379 -987
CLEC2B -3167 2668
CLTA 2554 -546
CLTC 4062 7259
CMTM6 3361 1926
CNN2 3453 -418
CNPY3 2729 1242
COMMD3 -986 -1962
COMMD9 2550 2239
COPB1 2918 2637
COTL1 4085 6761
CPNE1 -590 5132
CPNE3 1048 -1443
CPPED1 3892 -641
CRCP 2587 4708
CREB1 -1515 1422
CREBBP 2992 892
CREG1 3232 -1060
CRK 4125 6598
CRKL 1801 5167
CSF1 -64 356
CSK 3579 4890
CSNK2B 2032 4743
CSTB 3618 2893
CTF1 2341 543
CTLA4 -3797 7091
CTNNB1 3708 5070
CTSA 4396 2720
CTSB 4601 -965
CTSC 3524 1311
CTSD 4622 6622
CTSL 4053 3028
CTSO -3763 5111
CTSS 2262 -1546
CTSV -1434 5170
CTSZ 3863 -1980
CUL1 -4198 -1192
CUL2 -11 2207
CUL3 2149 -873
CUL5 -1067 344
CUL7 2070 6188
CXCL2 1260 -1990
CYB5R3 4351 3239
CYBA 3986 2019
CYFIP1 4146 256
CYFIP2 -275 6159
CYLD -4500 5706
CYSTM1 4253 -1742
DAPP1 -814 6838
DBNL 3790 -406
DCTN2 4142 -727
DCTN3 2319 2751
DCTN4 4296 4417
DCTN5 109 6060
DCTN6 2715 6882
DDX41 844 4426
DDX58 -3149 185
DEGS1 1101 3203
DERA 3556 3602
DET1 -1917 122
DGAT1 1776 -576
DHX36 -1604 6440
DHX58 -1478 -30
DHX9 -1435 5547
DIAPH1 2535 2371
DNAJC13 3848 408
DNAJC3 3801 6472
DNAJC5 4113 -1398
DNM1 2083 1607
DNM2 4115 3063
DPP7 -2367 6586
DSN1 -2049 -997
DTX4 3444 5144
DUSP3 3162 2260
DUSP4 -775 2494
DUSP6 -1141 -1943
DUSP7 -914 722
DYNC1H1 590 4434
DYNC1I2 2356 693
DYNC1LI1 3051 3242
DYNC1LI2 2757 -185
DYNLL1 521 5151
DYNLL2 -1889 -924
DYNLT1 2452 5601
DZIP3 -4479 -958
ECSIT 807 1450
EDARADD -3847 6841
EEA1 -61 5335
EEF1A1 -4394 2941
EEF2 -2501 4196
EGR1 -1531 1893
EIF2AK2 1924 683
EIF4A1 1909 881
EIF4A2 -4298 3601
EIF4A3 509 4598
EIF4E 577 6721
EIF4E2 1818 5876
EIF4E3 3665 -661
EIF4G1 4196 5766
EIF4G2 2337 6373
EIF4G3 4460 1034
ELMO1 1879 939
ELMO2 3996 6110
ENPP4 -108 3170
EP300 3773 4901
ERAP1 -2681 1806
ERAP2 1708 -756
ERP44 1654 920
EVL -4277 7075
FABP5 2875 2233
FADD 3278 -329
FAF2 2735 2842
FBXL12 124 4059
FBXL14 -1882 6756
FBXL15 563 970
FBXL16 -4579 6378
FBXL18 3658 853
FBXL19 4459 -220
FBXL20 2820 1213
FBXL22 -2437 5652
FBXL3 -112 2065
FBXL4 1975 1511
FBXL5 3942 6720
FBXL8 -1133 5373
FBXO11 2980 7064
FBXO15 312 2131
FBXO21 -2819 6290
FBXO22 -521 -930
FBXO30 1514 1907
FBXO31 -4375 4756
FBXO32 -4364 6488
FBXO4 -4430 106
FBXO6 1726 92
FBXO7 1478 2923
FBXO9 4585 3195
FBXW11 1937 -1508
FBXW2 4112 2654
FBXW4 -2929 136
FBXW5 1872 -1872
FBXW7 -468 6667
FBXW8 -1610 4559
FGR 4634 -1075
FKBP1A 3296 1814
FLNB 2888 675
FLT3LG -4565 6677
FOS 989 5647
FOXO1 -4379 3034
FOXO3 3778 5023
FTH1 2431 3117
FTL 3951 -1426
FUCA1 2246 1656
FUCA2 2092 -1236
FYN -2007 2793
FZR1 1357 2326
GAA 3208 2768
GAB2 4209 2390
GALNS 3403 3670
GAN 898 3655
GATA3 -4560 6274
GBP3 -3751 89
GCA 4472 5561
GDI2 2462 3343
GGH 2583 3861
GHDC 646 -571
GLB1 4012 1828
GLIPR1 1606 5593
GLMN -4125 -22
GM2A 4398 6363
GMFG 3602 6369
GNS 4663 4429
GOLGA7 8 3104
GPI 2530 5674
GRAP2 -764 3631
GRB10 4673 3328
GRB2 4326 6241
GRN 4392 4938
GSDMD 139 -91
GSTO1 3474 3633
GSTP1 -270 -1352
GUSB 4566 2338
GYG1 4408 -231
GZMM -2959 7252
HACE1 -1020 -395
HCST 79 1324
HEBP2 3182 552
HECTD1 763 5901
HECTD3 3584 463
HERC1 99 1913
HERC3 2199 3912
HERC4 1522 232
HERC5 -2754 -1038
HEXB 2779 2906
HGSNAT -268 3342
HIF1A 3384 2448
HLA-A -2359 -1094
HLA-B -33 -730
HLA-C 1043 4449
HLA-DMA -3206 -1928
HLA-E 727 5636
HLA-F -2137 2974
HLA-H -1015 4989
HMGB1 -2719 3222
HMOX2 -3853 6413
HNRNPA2B1 1073 2721
HNRNPF 452 5857
HRAS -2033 -823
HSP90AA1 -1535 6210
HSP90AB1 -4052 -1226
HSP90B1 -644 2127
HSPA1A 3554 -920
HSPA1B 3285 655
HSPA9 -4391 6551
HVCN1 -90 -385
ICAM1 388 2036
ICAM2 -4296 4819
ICAM3 2146 6840
ICAM5 4603 4186
ICOSLG -2475 4497
IDH1 4668 3454
IFI30 4068 -1604
IFI35 1210 1292
IFI6 1729 5537
IFIH1 -3138 2681
IFIT1 -1424 312
IFIT2 -3007 1477
IFIT3 -1745 6161
IFIT5 -2477 3745
IFITM1 -337 6985
IFNAR1 3726 1219
IFNAR2 3504 1115
IFNGR1 4264 4124
IFNGR2 4607 4231
IGF2R 4190 -1659
IKBKB 612 -912
IKBKE 3043 6705
IL10RA -392 5518
IL10RB 4541 -1076
IL12A -3249 -1317
IL12RB1 -1989 6632
IL12RB2 -3666 -1861
IL15 -1219 3611
IL15RA -341 -1087
IL16 -774 5458
IL17C 1369 -1130
IL17RA 4554 130
IL17RC -1660 1939
IL18BP -758 -1640
IL18R1 2772 6744
IL19 3115 7266
IL1RAP 3352 -1122
IL21R -3121 2722
IL23A -4517 7078
IL27RA 1981 6659
IL2RA -3245 6868
IL2RB -4326 7237
IL32 -3938 7268
IL4R 4114 1274
IL6R 2714 5066
IL6ST -68 1708
ILF2 -1669 2770
IMPDH1 4624 2600
IMPDH2 -4586 250
INPP5D 3395 55
INPPL1 4354 588
IP6K2 -143 799
IQGAP1 3914 587
IQGAP2 3127 3888
IRAK2 -1035 4686
IRAK3 4427 666
IRF1 -2321 5832
IRF2 3058 2365
IRF3 -2733 4241
IRF4 -3445 5941
IRF5 2465 -1651
IRF7 1413 3556
IRF9 626 4775
IRS1 -2377 4308
IRS2 3595 6152
ISG15 -1955 6541
ISG20 -2951 7060
IST1 3377 1014
ITCH 2375 4854
ITGA4 -3219 -394
ITGAL 1255 7038
ITGAV 2851 -370
ITGB2 4401 6426
ITGB7 -3493 -1691
ITK -4345 -1701
ITPR1 -1390 1789
ITPR2 2788 -44
ITPR3 -2430 2189
JAK1 -2489 -283
JAK2 1521 6489
JUN 1097 1283
JUNB 2595 5018
KBTBD6 874 80
KBTBD7 2759 -381
KBTBD8 -638 834
KCMF1 3111 3310
KCNAB2 2208 -600
KCTD6 1857 -621
KCTD7 -3701 1682
KEAP1 2919 1379
KIF11 204 1895
KIF15 -567 6309
KIF18A -145 3290
KIF20A 1313 1403
KIF22 -4444 6183
KIF23 1467 805
KIF2A -2793 4006
KIF2C 710 -12
KIF3A -4208 6174
KIF3B 1849 2018
KIF3C 3567 -1430
KIF5B 3015 4670
KIFAP3 -1460 -68
KLC1 3326 4386
KLC2 -2112 1505
KLC4 -1623 4367
KLHL11 -964 5349
KLHL2 4557 6411
KLHL20 -1734 1429
KLHL21 1459 5917
KLHL22 -3557 1129
KLHL25 -4073 4489
KLHL5 -3329 3248
KPNA1 -466 4423
KPNA2 -944 4421
KPNA3 -719 4400
KPNA4 1962 5000
KPNA5 -3957 1847
KPNB1 1929 1140
KRAS 2127 3139
LAIR1 4611 3425
LAMP1 3730 2553
LAMTOR1 3516 -1589
LAMTOR2 2924 -1342
LAMTOR3 1845 957
LAT2 4284 -1716
LCK -4275 7246
LCP1 4071 4312
LCP2 1292 -428
LGALS9 3873 -1462
LGMN -3257 2706
LIMK1 2952 -1750
LMNB1 4433 1051
LMO7 -4299 7262
LNPEP -414 2406
LONRF1 3305 6153
LPCAT1 2780 1418
LRR1 -2224 3790
LRRC41 4242 2878
LRRFIP1 3283 5297
LRSAM1 3807 5944
LTA -4249 7256
LTA4H 4219 798
LTB -4411 5586
LTN1 -771 7198
MALT1 -4548 2545
MAN2B1 1986 6389
MANBA 2776 6846
MAP2K1 3972 1533
MAP2K3 4118 2411
MAP2K4 2808 4764
MAP2K6 4449 4792
MAP2K7 529 1764
MAP3K1 2177 2247
MAP3K14 -3760 4221
MAP3K3 4156 3121
MAP3K7 1384 -147
MAP3K8 4618 3266
MAPK1 4578 6099
MAPK14 4535 2465
MAPK3 3753 1978
MAPK7 3913 -244
MAPK8 -3916 4554
MAPK9 -2113 157
MAPKAP1 1572 5908
MAPKAPK2 3308 3265
MAPKAPK3 4600 2896
MAVS 2983 4281
MEF2A 3832 3013
MEX3C -3194 6169
MGRN1 3709 -1405
MICA -126 3105
MICB 3507 3131
MIF -2932 3355
MKRN1 2299 2197
MLEC 281 2183
MLST8 -375 2258
MMP25 4503 6854
MNDA 3329 -1996
MPO -3556 -1969
MRC2 -1300 -577
MT2A 548 1186
MTAP -2661 2271
MTOR 616 3900
MUC1 1530 6715
MUC12 -670 4641
MUC5B 2214 -1745
MVP 3196 6955
MX1 -548 -1016
MX2 4410 1798
MYD88 4639 1945
MYH9 3495 6146
MYLIP -1884 2479
MYO9B 4389 6777
NAPRT 3965 -1871
NBEAL2 4333 1726
NCF4 4375 -1941
NCK1 -3937 1018
NCKAP1L 4625 -320
NCKIPSD -1401 667
NCSTN 4682 1224
NDC1 -4564 6482
NDUFC2 2060 2881
NEDD4 3710 -1106
NEDD4L 3426 -1080
NEU1 4519 1899
NF2 1417 1410
NFATC1 -2446 6947
NFATC2 -3694 7159
NFATC3 -2698 1668
NFKB2 -1330 5251
NFKBIA 1880 6814
NFKBIB 2414 5574
NFKBIE -2107 4747
NHLRC3 1715 4506
NIT2 -4039 -141
NKIRAS1 -2478 348
NKIRAS2 4516 -1132
NLRC5 -511 1905
NLRP1 -1865 3033
NLRP3 3356 -847
NLRX1 4376 768
NME2 -284 -880
NOD1 -1381 -321
NOD2 3888 6610
NOS3 -2969 4048
NPC2 1157 2198
NUP107 -3568 6301
NUP133 -2062 935
NUP153 96 4344
NUP155 -2910 3043
NUP160 -3599 1293
NUP188 -3388 2922
NUP205 -3151 1670
NUP210 -1503 690
NUP214 3964 4369
NUP35 -4376 -557
NUP37 -837 3398
NUP43 -3605 6346
NUP50 935 6706
NUP54 -2949 831
NUP62 -899 4609
NUP85 -1286 4518
NUP88 -4340 7084
NUP93 -2587 2006
NUP98 2030 -747
OAS1 677 -1507
OAS2 -1880 6618
OAS3 -1767 616
OASL 2421 5929
ORAI1 -2266 2153
ORAI2 3079 -132
ORMDL3 -2451 3085
OSCAR 4669 7123
OSM 3158 1355
OSTF1 3075 6470
P2RX1 4678 -1949
P4HB 3946 5718
PA2G4 -2025 5243
PAFAH1B2 2082 2435
PAG1 2103 6279
PAK1 3920 2452
PAK2 3401 283
PANX1 3037 3960
PCBP2 90 3201
PDAP1 3390 2952
PDCD4 -4493 4220
PDE12 -223 6083
PDIA3 1403 4846
PDPK1 3242 346
PDXK 3046 1492
PELI1 1650 1867
PELI2 2137 7035
PELI3 3441 -1123
PFKL -1324 -1732
PGAM1 4544 1307
PGM1 2586 776
PGM2 4121 5134
PIAS1 2481 2845
PIK3AP1 4412 1373
PIK3CA 749 1470
PIK3CD 3357 6109
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R3 943 3645
PIK3R4 -767 2170
PILRB -1712 2683
PIM1 2662 1390
PIN1 214 4014
PITPNA 4148 3616
PJA2 3209 2112
PKM 4204 3231
PLA2G6 -2968 826
PLAC8 4540 1235
PLAU 1336 -1529
PLAUR 4189 -861
PLCG1 -4193 958
PLCG2 4027 2803
PLD1 4524 -902
PLD3 2198 354
PLEKHO2 4499 6699
PML -294 4575
PNP 2941 3516
POLR1C -4031 5329
POLR1D 589 6782
POLR2E 1754 3712
POLR2F 1457 509
POLR2H -2461 6299
POLR2K -1891 3853
POLR3A 1126 5226
POLR3C -1707 3978
POLR3D -3951 1967
POLR3E -3745 1113
POLR3F -3279 -1023
POLR3G -2957 6661
POLR3GL -987 204
POLR3H -4357 5546
POLR3K -734 891
POM121 -48 4681
POM121C -623 2061
POU2F1 2852 3909
PPIA -2610 4555
PPIE -2531 6027
PPM1B 2812 -144
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5A 3798 -230
PPP2R5B 3843 -286
PPP2R5C -2002 7074
PPP2R5D 2308 3470
PPP2R5E -960 1402
PPP3CA 1228 5980
PPP3CB 2123 4044
PPP3R1 1915 2945
PRCP 3166 611
PRDX6 1745 5478
PRKACA 4651 890
PRKACB -4452 1712
PRKCB 3189 4964
PRKCD 4562 6360
PRKCE 3011 -1185
PRKCQ -4200 4208
PRKCSH 2404 4698
PRKDC -1555 6476
PRR5 -2760 -347
PRTN3 -4157 5621
PSAP 3330 628
PSEN1 4153 4955
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
PSTPIP1 4165 680
PTEN 3653 4815
PTGES2 -2116 -901
PTK2 147 -475
PTK2B 4572 4529
PTPN1 4262 699
PTPN11 2272 5062
PTPN12 2791 -982
PTPN13 -2382 6850
PTPN18 4432 3436
PTPN2 3465 181
PTPN22 2470 5982
PTPN23 2552 5427
PTPN4 -3616 784
PTPN6 4161 6542
PTPN7 -233 2323
PTPN9 4514 6096
PTPRC 2931 -936
PTPRJ 4090 7170
PTPRN2 1668 6585
PYCARD 4218 -1820
PYGB -154 141
QPCT 4310 -1474
QSOX1 4653 5727
RAB10 4448 3067
RAB14 1884 -378
RAB18 2497 2764
RAB24 3694 -168
RAB27A 3688 222
RAB37 -373 409
RAB3A 2176 4348
RAB3D 4294 1148
RAB4B 3134 4688
RAB5B 3040 1957
RAB5C 3819 797
RAB6A 3874 3323
RAB7A 3957 -124
RAC1 4263 5541
RAC2 3032 4577
RACGAP1 2043 4089
RAE1 1714 2634
RAF1 3715 6573
RALA -2555 2302
RANBP2 -405 5165
RAP1A 2631 6569
RAP1B 2468 5968
RAP2B 1340 5292
RAPGEF1 1750 6445
RASGRP1 -4180 5888
RASGRP2 -2424 -413
RASGRP3 -2744 760
RBBP6 -2144 2861
RBCK1 3143 -510
RBSN 404 6354
RBX1 1356 5883
RCHY1 1225 6486
REL 2660 1779
RELA -73 4333
RELB 824 577
RHOA 3580 4033
RHOF -3792 6478
RHOG 4271 3664
RICTOR -2029 2833
RILP 3543 4299
RIPK3 4479 6795
RNASEL 4378 3400
RNASET2 2898 7090
RNF111 2486 6049
RNF114 916 6
RNF115 -1560 5805
RNF123 3856 5285
RNF125 -4414 6176
RNF126 -3523 5634
RNF135 4467 -1615
RNF138 -3195 7053
RNF14 1765 -1372
RNF144B 4014 -81
RNF19A -735 6514
RNF19B 2408 2765
RNF213 -890 7097
RNF216 -2878 4491
RNF220 -1197 215
RNF25 -533 5177
RNF34 -38 1414
RNF4 -562 4133
RNF41 4047 4402
RNF6 -136 366
RNF7 2676 5841
ROCK1 3235 2732
RORA -4061 6933
RPLP0 -4084 4851
RPS27A -4373 2589
RPS6KA1 4529 -1859
RPS6KA2 1506 2117
RPS6KA5 -4174 1991
S100A11 4428 6089
S100P 3846 3303
S1PR1 -1593 6791
SAMHD1 3411 6191
SAR1B 2437 3060
SARM1 -3567 4842
SCAMP1 -3040 2645
SDCBP 3866 3834
SEC13 2700 6211
SEC23A 2536 1833
SEC24A 3587 4762
SEC24B 2639 -13
SEC24C 3376 -336
SEC24D 4369 1527
SEC31A 1492 2523
SEC61A1 2689 421
SEC61A2 -2056 301
SEC61B 1487 6424
SEC61G -1179 1928
SEH1L -4285 3577
SERPINB1 4518 -1479
SERPINB6 1810 2823
SH2B1 -2131 1436
SH2B3 2353 3851
SHC1 3650 3205
SIAH1 1013 494
SIAH2 2540 6697
SIGIRR -2791 6807
SIKE1 -1946 1675
SIPA1 3194 -1270
SKP1 -2513 2680
SKP2 -683 1707
SLA 4302 6986
SLA2 -2507 4871
SLAMF6 -3389 6836
SLC11A1 4685 4001
SLC15A4 4298 -1577
SLC27A2 -2500 -1411
SLC2A3 4316 -1211
SLC44A2 1778 4323
SLCO4C1 3151 -99
SMAD3 -3344 -363
SMARCA4 2865 6792
SMURF1 2253 6934
SMURF2 -2298 3523
SNAP23 2713 -471
SNAP29 3459 3148
SNRPA1 -3010 1539
SOCS1 1609 4130
SOCS2 -1186 6479
SOCS3 4385 6492
SOCS5 108 466
SOD1 -3096 1838
SOD2 2609 6134
SOS1 -1111 -1986
SOS2 3749 3699
SP100 3525 2285
SPSB1 991 582
SPTAN1 -4222 -407
SQSTM1 -748 658
SRC -2558 -1476
SRP14 1720 5764
STAT1 -4215 4970
STAT2 -1314 5933
STAT3 3745 4995
STAT4 -3864 4203
STAT5A 2844 -1545
STAT5B 3260 1495
STAT6 3810 3854
STBD1 1952 -658
STIM1 3982 7265
STK10 3375 -688
STK11IP 3318 2122
STOM 2913 -1586
STUB1 -996 2320
STX1A 1229 4174
STX3 3994 2712
STX4 2492 1609
STXBP2 4615 -155
SUGT1 -1217 5005
SUMO1 1392 3368
SURF4 3061 3679
SVIP -1140 1104
SYK 4033 431
TAB2 693 6401
TALDO1 4129 4422
TANK 3188 6239
TAP1 -2657 3742
TAP2 -1545 3057
TAPBP 2376 2910
TAX1BP1 1803 1037
TBC1D10C -3207 6912
TBK1 1669 599
TCIRG1 4550 1353
TCP1 -1621 -448
TEC 3772 170
TGFB1 1897 3769
THEM4 -4578 809
THOP1 -2309 3555
TICAM1 3321 1060
TIFA -537 4848
TIRAP 3312 1661
TLR1 3931 -1113
TLR2 4215 4128
TLR3 -3090 2949
TLR5 4577 5701
TLR6 3415 -1201
TLR9 -10 7204
TMBIM1 4002 -47
TMC6 -2639 6750
TMEM179B -609 5597
TMEM30A 2493 6660
TMEM63A -3402 2620
TNF -477 -526
TNFAIP3 -842 6105
TNFRSF12A 3482 681
TNFRSF1A 4465 -1548
TNFRSF1B 3940 6870
TNFRSF25 -4584 6989
TNFSF13 3950 -1364
TNFSF13B 2697 -384
TNFSF14 3206 7178
TNFSF9 999 447
TNIP2 2832 287
TOLLIP 3713 664
TOM1 4248 4280
TP53 -4050 2709
TPP2 -3824 2610
TPR -1423 4616
TRAF2 -3119 5765
TRAF3 -3164 7209
TRAF6 1605 -71
TRAF7 4399 4601
TRAIP -2607 2585
TRAPPC1 3425 5233
TREML2 3789 -1970
TREX1 55 -1436
TRIB3 875 3767
TRIM11 467 5179
TRIM14 2094 1982
TRIM2 -4169 646
TRIM21 1631 -1673
TRIM22 -557 2278
TRIM25 4522 446
TRIM26 1318 3540
TRIM35 -2674 1556
TRIM36 956 -1287
TRIM37 -1042 3725
TRIM38 1611 4883
TRIM39 -1308 6698
TRIM4 -1426 7144
TRIM41 3548 7011
TRIM45 -2937 -1041
TRIM46 -3922 3136
TRIM5 2620 395
TRIM56 -1054 5740
TRIM62 -159 3890
TRIM68 -2799 -539
TRIM8 4311 6375
TRIM9 3012 3459
TRIP12 3880 6255
TRPC1 -3752 -631
TRPM2 4547 -1794
TSPAN14 4341 4963
TUBB -611 6248
TUBB4B 3129 7163
TXK -4318 4860
TXLNA 1079 7007
TXN 3518 -1735
TXNDC5 -784 -1873
TXNIP -1950 6154
TYK2 4387 4072
TYROBP 3696 -1997
UBA3 2802 4052
UBA5 -2672 911
UBA52 -1313 -69
UBA6 1705 -917
UBA7 -1131 -1591
UBAC1 3239 -157
UBB 355 5059
UBC 2129 3220
UBE2B 1401 5147
UBE2C 1233 4535
UBE2D1 3526 2741
UBE2D2 -290 2134
UBE2D3 3214 3005
UBE2D4 -3411 915
UBE2E1 -1112 2408
UBE2E2 -2124 2070
UBE2E3 -359 -777
UBE2F 3870 6897
UBE2G1 1353 214
UBE2G2 -4262 6799
UBE2H 3422 1146
UBE2J1 3617 1013
UBE2J2 2602 6013
UBE2K 1774 3260
UBE2L3 2629 119
UBE2L6 -3276 1295
UBE2M 2658 2052
UBE2N -757 4834
UBE2O -396 6887
UBE2Q1 1920 2054
UBE2Q2 -4245 -223
UBE2R2 4108 -1209
UBE2S 1641 -706
UBE2V1 -446 2792
UBE2V2 -804 3547
UBE2W 2104 5413
UBE2Z -2852 6571
UBE3A -663 2812
UBE3B 2500 709
UBE3C 1942 6991
UBE3D -3476 -1597
UBOX5 1747 5848
UBR1 704 460
UBR2 2805 2591
UFL1 -1234 3864
UNC13D 4608 -1906
UNC93B1 4207 4749
UNKL 676 -1603
USP18 -542 -1013
VAMP2 -3788 -1239
VAMP3 3540 619
VAMP8 -46 868
VAPA 3695 4246
VASP 4052 1142
VAT1 4456 -1359
VAV1 4015 5834
VAV2 975 4134
VAV3 3114 -685
VCL 2144 3614
VCP 2829 1908
VEGFA 1946 87
VHL 930 5209
VIM 4470 3780
VRK3 2567 2903
VTN 610 -1927
WASF1 4637 -830
WASF2 4371 -134
WASL 1150 4645
WIPF1 1102 -784
WIPF2 3237 -1018
WSB1 4397 4175
WWP1 -4510 479
XAF1 -2052 -1464
XRCC5 637 1327
XRCC6 -3489 3282
YES1 -1057 5198
YPEL5 2611 3986
YWHAB 1621 2152
YWHAZ 1788 4294
ZAP70 -3837 7251
ZBP1 -2358 7177
ZBTB16 2438 -42
ZEB1 -2893 5937
ZNRF1 141 -819
ZNRF2 -916 3277



Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
metric value
setSize 70
pMANOVA 2.39e-26
p.adjustMANOVA 3.96e-24
s.dist 0.763
s.RNA -0.734
s.meth 0.205
p.RNA 2.06e-26
p.meth 0.00305




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599
RPL37 -3340 5393
RPS7 -4048 4408

Click HERE to show all gene set members

All member genes
RNA meth
EEF1A1 -4394 2941
EEF1B2 -4380 3976
EEF1D -2214 5791
EEF1G -4126 111
EEF2 -2501 4196
FAU -1368 6877
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
UBA52 -1313 -69



Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
metric value
setSize 76
pMANOVA 8.93e-26
p.adjustMANOVA 1.3e-23
s.dist 0.723
s.RNA -0.7
s.meth 0.182
p.RNA 4.84e-26
p.meth 0.00622




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599
RPL37 -3340 5393
RPS7 -4048 4408

Click HERE to show all gene set members

All member genes
RNA meth
EIF3A -452 5855
EIF3B -4255 -704
EIF3E -3975 503
EIF3F -2004 1471
EIF3G -1016 3038
EIF3H -2928 3706
EIF3I -957 696
EIF3J -2581 737
EIF3K -877 6636
EIF3L -3550 2568
EIF3M -2777 5836
FAU -1368 6877
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
UBA52 -1313 -69



Peptide chain elongation

Peptide chain elongation
metric value
setSize 67
pMANOVA 3.94e-25
p.adjustMANOVA 5.08e-23
s.dist 0.761
s.RNA -0.732
s.meth 0.208
p.RNA 3.43e-25
p.meth 0.00329




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599
RPL37 -3340 5393
RPS7 -4048 4408

Click HERE to show all gene set members

All member genes
RNA meth
EEF1A1 -4394 2941
EEF2 -2501 4196
FAU -1368 6877
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
UBA52 -1313 -69



Signal Transduction

Signal Transduction
metric value
setSize 1290
pMANOVA 5.27e-25
p.adjustMANOVA 6.12e-23
s.dist 0.179
s.RNA 0.171
s.meth 0.0528
p.RNA 5.57e-23
p.meth 0.0023




Top 20 genes
Gene RNA meth
FURIN 4424 7181
ATP6V0D1 4480 6936
CTSD 4622 6622
KSR1 4237 7147
MYO9B 4389 6777
CLTC 4062 7259
PTPRJ 4090 7170
PRKCD 4562 6360
SOCS3 4385 6492
GNG5 4320 6512
MAPK1 4578 6099
ACTN1 3787 7240
ECE1 4374 6249
GMIP 4642 5869
PTPN6 4161 6542
CRK 4125 6598
SHB 4083 6644
RALB 3954 6833
GRB2 4326 6241
GIT2 4344 6162

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1256 1467
AAMP -2521 7121
AATF 2745 5313
ABCA1 2264 -82
ABCD3 618 5775
ABCG1 -3462 6771
ABHD12 -1857 5950
ABHD17A -1574 -550
ABHD17B -1618 -676
ABHD6 2336 2533
ABI1 3566 3253
ABI2 -3506 -206
ABL1 2124 2469
ABL2 1414 5308
ABR 4602 4699
ACBD5 1825 2753
ACTA2 -56 4718
ACTB 4254 5447
ACTG1 3711 1603
ACTN1 3787 7240
ACTR2 3331 3844
ACTR3 3319 5952
ACVR1B 4652 -23
ACVR2A -4506 6957
ADAM10 3893 2760
ADAM17 4453 4155
ADAP1 3944 -1541
ADCY4 3370 -1006
ADCY7 2655 -981
ADCY9 -1063 5439
ADD3 1272 4727
ADGRE5 3345 -1470
ADM 4679 5105
ADORA2A 1463 7186
ADORA3 2150 -1897
ADRB2 -1168 2808
AGO1 3289 7140
AGO2 2116 7196
AGO3 899 3465
AHCTF1 -84 -864
AHCYL1 2529 2692
AKAP13 3191 4322
AKT1 2261 1109
AKT1S1 3113 1894
AKT2 1896 5431
ALDH3A2 -526 5655
AMIGO2 -3503 -696
ANKFY1 2502 6513
ANKLE2 407 3585
ANKRD26 -2267 3643
ANLN 912 410
AP2A1 4643 -316
AP2M1 3281 3723
AP2S1 2943 6039
APBB1IP 4261 3821
APC 1724 1992
APH1A 904 -119
APH1B 3616 6785
APP 2164 6623
ARAP1 4330 1485
ARAP2 -1182 5752
ARF6 1056 3741
ARFGAP3 2664 724
ARHGAP1 4162 -524
ARHGAP10 -2826 6501
ARHGAP11A 1169 109
ARHGAP11B 1847 3318
ARHGAP12 -312 1249
ARHGAP15 -1959 4591
ARHGAP17 -2637 6872
ARHGAP18 3371 2306
ARHGAP19 3799 5728
ARHGAP21 339 6460
ARHGAP23 2688 6788
ARHGAP25 1054 -568
ARHGAP26 4517 -247
ARHGAP27 4468 -1908
ARHGAP30 3339 2549
ARHGAP35 -807 2758
ARHGAP39 -1586 6949
ARHGAP5 -4465 6630
ARHGAP9 3724 6257
ARHGDIA 2953 6670
ARHGDIB 3923 1149
ARHGEF1 444 4487
ARHGEF12 1424 5964
ARHGEF17 3363 1438
ARHGEF19 -3845 -87
ARHGEF2 3777 1182
ARHGEF26 -21 6999
ARHGEF3 -3613 3996
ARHGEF39 -2231 -1564
ARHGEF7 -172 330
ARL13B -1878 950
ARL2 -1193 244
ARL4C -3702 2467
ARPC1B 4355 1709
ARPC2 3393 2292
ARPC3 3253 3208
ARPC5 3952 2611
ARRB1 1355 -1278
ARRB2 4301 2913
ASH2L 3309 3075
ATF1 901 2989
ATN1 -352 3096
ATP2A1 1366 5724
ATP2A2 4104 -1550
ATP2A3 1257 1877
ATP6V0A1 4614 -1571
ATP6V0A2 -2659 6653
ATP6V0B 3770 5503
ATP6V0C 4469 2933
ATP6V0D1 4480 6936
ATP6V0E1 3116 1836
ATP6V0E2 -4219 -1327
ATP6V1A 3646 -1497
ATP6V1B2 3599 -1555
ATP6V1C1 3836 6759
ATP6V1D 3887 1096
ATP6V1E1 3016 4776
ATP6V1F 1310 -699
ATP6V1G2 -4032 3740
ATP6V1H 2526 2559
AURKB 699 5274
AXIN1 -1113 -858
AXIN2 -3719 152
B4GALT1 2813 7043
B9D2 3251 1211
BAD 2600 4374
BAG4 3706 828
BAIAP2 -676 2757
BAMBI 4225 3576
BAX 1873 1161
BCL2 -2865 7022
BCL2L1 1700 5970
BCL2L11 3454 5664
BCL9 -871 4909
BCR 520 -1913
BIRC2 954 6626
BIRC3 -4544 4817
BIRC5 1558 1965
BMI1 -3597 -805
BMPR1A -2197 5829
BMPR2 2585 6822
BRAF 1497 -1526
BRAP 2154 -135
BRK1 -951 3071
BTRC -1609 -923
BUB1 346 67
BUB1B -1025 1523
BUB3 -4307 1717
C1QBP -4004 5787
C3AR1 4621 -1596
CAB39 3568 7109
CAB39L -24 6420
CALM1 -444 4502
CAMK2D -4472 -529
CAMK2G 891 6718
CAMK4 -4589 2759
CAMKK1 4169 5614
CAMKK2 4276 1010
CAPZB 3664 -308
CASP10 347 -1807
CASP3 1520 5691
CASP8 -1853 5448
CASP9 4573 3202
CAV1 779 4592
CBFB 185 5862
CBL 3838 1012
CBX4 2670 278
CBX6 1804 3612
CBX8 927 4611
CBY1 -3658 3274
CCDC115 -1075 3962
CCDC88A 3220 2063
CCDC88C -1770 6961
CCNC -2845 4188
CCND1 -1449 1006
CCND3 4181 4156
CCNE1 -1399 5956
CCNK 2940 6593
CCNT1 -1482 1761
CCR1 3634 -1921
CCR10 -3566 2454
CCR7 -4238 7127
CCT2 -4536 194
CCT6A -4162 4843
CCT7 -1970 6030
CD55 4431 1455
CDC14A -4595 3991
CDC14B -2318 1870
CDC20 1603 2639
CDC25C 2001 5507
CDC42 3077 856
CDC42EP3 3877 1427
CDC42EP4 3882 1301
CDC42SE2 -4525 6136
CDC73 2159 5719
CDCA8 113 20
CDK1 -959 1888
CDK2 -1366 2965
CDK4 -4024 4919
CDK5 4265 3491
CDK5R1 469 7124
CDK8 1491 5795
CDK9 1936 3144
CDKN1A 1908 2427
CDKN1B -1167 3367
CDON -2436 1466
CENPA 865 72
CENPE 2054 -74
CENPF 1563 -400
CENPH -4116 84
CENPK -2707 1612
CENPL -1652 4694
CENPM -3675 6494
CENPN -408 1070
CENPO 2344 4161
CENPP 245 2080
CENPQ -2886 3793
CENPT -3043 4798
CENPU -1731 433
CEP97 1158 -1465
CFL1 3776 1646
CFLAR 4283 3140
CHD1 -18 1273
CHD3 -2622 6050
CHD4 107 640
CHD8 2824 -916
CHEK1 -2434 51
CHN1 -3730 5361
CHUK 3252 1111
CIT 1086 5654
CKAP4 4379 -987
CKAP5 1014 3384
CKB 496 4735
CLASP1 2479 2114
CLASP2 -708 -77
CLIP1 4277 921
CLIP3 -3479 7133
CLTA 2554 -546
CLTB 2902 -918
CLTC 4062 7259
CNOT6L -3586 6262
CNR2 -1951 -1987
COL9A2 601 4444
COPS2 325 6456
COPS4 -1011 5826
CPD 4315 -1840
CPNE8 1823 4671
CPT1A 1797 -1598
CREB1 -1515 1422
CREBBP 2992 892
CRK 4125 6598
CRKL 1801 5167
CSK 3579 4890
CSNK1A1 3045 4452
CSNK1E -2625 3000
CSNK1G2 1349 2563
CSNK2A2 2634 5736
CSNK2B 2032 4743
CTBP1 1028 6471
CTNNB1 3708 5070
CTNNBIP1 2340 1589
CTNND1 868 -1709
CTSD 4622 6622
CUL1 -4198 -1192
CUL3 2149 -873
CUL5 -1067 344
CXCL2 1260 -1990
CXCR4 -442 -1435
CXXC5 -2575 1039
CYBA 3986 2019
CYFIP1 4146 256
CYFIP2 -275 6159
CYLD -4500 5706
DAAM1 -1194 6127
DACT1 80 6080
DAGLB 4088 -302
DBN1 2366 6172
DBT -1093 3500
DDRGK1 2954 6493
DDX5 -2667 1804
DEF6 -1030 742
DEPDC1B 1251 2392
DERL2 23 -1578
DGKA -3866 7033
DGKD 2424 4806
DGKE -3765 6507
DGKG 3030 4393
DGKH -872 4127
DGKQ -377 3114
DGKZ -854 -1315
DHRS3 -3987 1303
DHRS4 -474 635
DIAPH1 2535 2371
DISP2 -1595 5406
DLAT -673 3896
DLD 2733 3542
DLG1 -2320 358
DLG2 578 -40
DLG4 3788 2607
DLGAP5 1614 -1160
DNAJB1 -2166 6095
DNAL4 -273 2609
DNM1 2083 1607
DNM2 4115 3063
DNMBP 2740 -1643
DOCK10 -3843 -1158
DOCK4 4317 4094
DOCK7 -1565 2327
DOCK8 3682 900
DOCK9 -4424 5506
DRAP1 1027 5794
DSN1 -2049 -997
DST -2782 1704
DTX4 3444 5144
DUSP1 2842 2023
DUSP10 -350 4700
DUSP16 -3527 28
DUSP2 -3108 7009
DUSP3 3162 2260
DUSP4 -775 2494
DUSP5 -501 6280
DUSP6 -1141 -1943
DUSP7 -914 722
DVL1 -1784 6368
DVL2 -2195 4884
DVL3 4159 161
DYNC1H1 590 4434
DYNC1I2 2356 693
DYNC1LI1 3051 3242
DYNC1LI2 2757 -185
DYNC2H1 -2328 5992
DYNLL1 521 5151
DYNLL2 -1889 -924
E2F1 2395 3145
E2F3 3565 2135
E2F4 1792 1015
E2F5 -2715 4181
EBAG9 -3576 4461
ECE1 4374 6249
ECT2 1489 -1207
EED -2776 3088
EEF2K -2933 4092
EEPD1 190 3578
EFCAB7 -2678 -250
EFHD2 4229 -127
EGR1 -1531 1893
EGR2 -2670 4748
EIF4B -3517 5587
EIF4E 577 6721
EIF4EBP1 1003 4398
EIF4G1 4196 5766
ELMO1 1879 939
ELMO2 3996 6110
EP300 3773 4901
EPAS1 4592 4596
EPN1 4307 5034
EPOR 4140 3155
EPS15 2107 -516
EPS15L1 3140 2728
EPSTI1 -2089 293
ERBB2 -2433 4160
ERLEC1 329 1240
ESR2 -3284 4784
ESRP2 360 -276
ESYT1 -4324 4321
EVL -4277 7075
EZH2 -1432 2695
F11R 1293 -1146
FABP5 2875 2233
FADD 3278 -329
FAF2 2735 2842
FAM135A -4268 464
FAM13A 2882 1054
FAM13B -2439 5114
FAM91A1 2101 2501
FARP2 -2837 -921
FAS 437 825
FASN -642 4278
FBXW7 -468 6667
FER -250 2567
FES 4457 -1638
FGD3 3310 1922
FGF9 -3672 997
FGFBP3 -1105 207
FGFRL1 -278 5867
FKBP1A 3296 1814
FKBP4 -1907 2679
FKBP5 4458 -681
FLOT1 4558 422
FLOT2 4246 5524
FLT3LG -4565 6677
FMNL1 3514 3934
FMNL3 -3452 -90
FNBP1 1674 2510
FNTA -941 694
FNTB 662 -1385
FOS 989 5647
FOSB -810 1975
FOSL1 2848 6224
FOXO1 -4379 3034
FOXO3 3778 5023
FRAT1 4177 5692
FRAT2 4335 4158
FRS2 -406 -882
FRS3 2782 6525
FSTL3 4584 5264
FURIN 4424 7181
FUZ 523 -944
FYN -2007 2793
FZD2 1758 2618
FZD3 -2350 6062
FZD5 4676 2664
FZD6 -3645 735
FZD7 -2239 2145
FZD8 -2438 2234
GAB2 4209 2390
GABBR1 -36 -1490
GALNT3 3280 -712
GAS8 138 -619
GATA3 -4560 6274
GATAD2A 2436 189
GATAD2B 2076 5595
GFOD1 1237 5190
GGA3 3155 671
GIPR -3224 -792
GIT1 -2797 -1972
GIT2 4344 6162
GLI1 2831 5203
GMIP 4642 5869
GNA12 -295 4303
GNA13 1819 3330
GNA15 4425 -1924
GNAI2 4039 3218
GNAI3 3078 2359
GNAL 326 3638
GNAQ 3823 -1832
GNAS 2061 -60
GNAT1 660 705
GNB1 4127 2799
GNB2 4050 1879
GNB4 2511 1335
GNB5 -1874 6256
GNG2 1099 6500
GNG3 1539 7142
GNG4 870 6856
GNG5 4320 6512
GNG7 -2307 -499
GNGT2 511 7120
GNRHR2 -919 1263
GOLGA3 136 4570
GOLGA7 8 3104
GOPC -3143 2529
GPAM -3583 81
GPR132 1881 1930
GPR183 -4571 741
GPR35 3274 -1793
GPR65 2496 3227
GPR68 -2352 -285
GPS1 -882 6190
GPS2 896 6830
GPSM2 2876 -92
GPSM3 2758 3761
GRAP2 -764 3631
GRB10 4673 3328
GRB2 4326 6241
GRIN2D 3691 3069
GRK5 -1323 6891
GRK6 3290 3634
GSK3A 3885 2534
GSK3B 2544 4908
GTF2A1 -425 1479
GTF2A2 752 286
GTF2F1 2368 558
GTF2F2 2169 5307
HBEGF 729 -1007
HDAC1 239 3287
HDAC10 852 4924
HDAC11 1885 6084
HDAC2 -2809 5864
HDAC3 1870 7116
HDAC4 4413 887
HDAC5 1171 3068
HDAC7 2654 -487
HEBP1 2287 314
HGS 3544 4351
HHAT -1981 459
HIF1A 3384 2448
HINT2 -1892 -607
HMOX2 -3853 6413
HNRNPC 1462 213
HNRNPF 452 5857
HNRNPH1 -3044 2373
HNRNPM 1556 2773
HRAS -2033 -823
HRH2 4670 -109
HSP90AA1 -1535 6210
HSP90AB1 -4052 -1226
HSPB1 -556 883
HSPE1 -3983 3593
ICMT 53 2626
ID1 2998 5399
ID2 3611 1192
ID3 -1581 -55
IER3 2322 1545
IFT122 2047 3149
IFT140 -3625 5911
IFT172 -2129 -1247
IFT52 -1322 320
IFT57 -497 1594
IGF1R 2444 -1422
IKBKB 612 -912
IKZF1 -436 5424
IL1RAP 3352 -1122
IL2RA -3245 6868
IL2RB -4326 7237
IL32 -3938 7268
IL6R 2714 5066
IL6ST -68 1708
INCENP 1329 5539
INSR 3577 3558
IQGAP1 3914 587
IQGAP2 3127 3888
IRS1 -2377 4308
IRS2 3595 6152
ITCH 2375 4854
ITGA2 -1406 -260
ITGAV 2851 -370
ITGB3BP -3549 -83
ITPR1 -1390 1789
ITPR2 2788 -44
ITPR3 -2430 2189
ITSN1 4329 3959
JAK1 -2489 -283
JAK2 1521 6489
JUN 1097 1283
JUNB 2595 5018
JUND -840 4243
KANK1 -4183 4095
KAT2A -3982 1343
KAT2B 726 4028
KAT5 1234 1952
KBTBD7 2759 -381
KCTD13 -72 638
KCTD3 2543 6969
KCTD6 1857 -621
KDM1A -3041 5493
KDM1B 3180 -425
KDM3A -4471 -504
KDM4A 3217 3870
KDM4B 4157 1541
KDM4C -1271 6227
KHDRBS1 -522 1137
KIDINS220 3553 3650
KIF14 1966 -596
KIF18A -145 3290
KIF2A -2793 4006
KIF2C 710 -12
KIF3A -4208 6174
KIF5B 3015 4670
KLC1 3326 4386
KLC2 -2112 1505
KLC4 -1623 4367
KLHL12 4073 3615
KMT2D 3314 6495
KNTC1 -2621 429
KPNA2 -944 4421
KRAS 2127 3139
KSR1 4237 7147
KTN1 -850 -1506
LAMA2 -1282 6004
LAMB2 -17 1884
LAMTOR1 3516 -1589
LAMTOR2 2924 -1342
LAMTOR3 1845 957
LAMTOR4 2085 7000
LAMTOR5 3327 -881
LATS1 -852 -841
LATS2 2904 103
LBR 3297 2128
LCK -4275 7246
LEMD3 -306 3474
LEO1 -276 4252
LEPR 622 2863
LETM1 653 5495
LFNG 420 6685
LIMK1 2952 -1750
LIMK2 3717 116
LIN7B -334 992
LMAN1 -3700 5995
LMNB1 4433 1051
LPAR2 3999 -1083
LPAR5 83 6315
LPAR6 -3871 7276
LRIG1 -4518 -692
LRP5 -1475 -123
LRP6 -2999 1600
LRRC1 -3266 2539
LRRC41 4242 2878
LTB4R 4567 -1918
LTB4R2 1725 -1806
LYL1 3875 -1349
LYPLA1 2477 2159
MAD1L1 657 2466
MAD2L1 -3255 -200
MADD 1104 -1304
MAF1 1423 6181
MAML1 3921 1442
MAML2 -2945 4627
MAML3 4280 3460
MAP2K1 3972 1533
MAP2K2 2576 6410
MAP2K5 788 3448
MAP3K11 4116 1270
MAP3K7 1384 -147
MAPK1 4578 6099
MAPK14 4535 2465
MAPK3 3753 1978
MAPK6 3071 257
MAPK7 3913 -244
MAPK8 -3916 4554
MAPKAP1 1572 5908
MAPKAPK2 3308 3265
MAPKAPK3 4600 2896
MAPRE1 2867 -441
MARK3 4359 3805
MBD3 -2339 6240
MDM2 2097 2095
MED1 -348 4473
MEF2A 3832 3013
MEF2D 2521 177
MEMO1 2679 1334
MEN1 -2073 1903
MFN1 -1153 1048
MFN2 3109 -1030
MFNG -3205 6333
MIB1 -2032 3187
MIS12 -3782 4937
MKNK1 4078 1392
MKRN1 2299 2197
MKS1 -3079 4513
MLST8 -375 2258
MOB1B 837 3562
MOV10 -2344 -1882
MSI2 -2497 -1088
MST1 2015 1923
MST1R -1239 -1885
MTA2 1016 5579
MTA3 -2954 5162
MTMR4 2768 3784
MTOR 616 3900
MTR -3643 6467
MTX1 4553 -1299
MXD4 -1411 6707
MYB -1717 -449
MYD88 4639 1945
MYH10 3211 5544
MYH9 3495 6146
MYL6 3993 2012
MYLIP -1884 2479
MYO19 -1247 772
MYO6 -1328 1793
MYO9A -896 6338
MYO9B 4389 6777
NAB1 813 5391
NAB2 -1510 3891
NBEA -2688 7003
NCBP1 -340 5859
NCBP2 -4320 4777
NCF4 4375 -1941
NCK1 -3937 1018
NCK2 -1079 1378
NCKAP1L 4625 -320
NCKIPSD -1401 667
NCOA2 2872 2432
NCOA3 3005 3815
NCOR1 2997 -530
NCOR2 4583 -1609
NCSTN 4682 1224
NDC80 -2364 4579
NDE1 1523 1067
NDEL1 4136 2477
NDUFA5 -3686 4945
NDUFS3 -246 3397
NEDD4 3710 -1106
NEDD4L 3426 -1080
NEDD8 2724 -105
NELFB 627 -649
NET1 -3236 -1883
NF1 2994 -328
NF2 1417 1410
NFATC1 -2446 6947
NFKBIA 1880 6814
NLK 2036 -208
NLN 2174 6770
NMB -1868 -273
NOS3 -2969 4048
NOTCH1 3629 6291
NOTCH4 4055 4962
NOXA1 -1895 -376
NPHP4 433 4778
NR1H2 3638 6463
NR1H3 330 6206
NR3C1 353 3509
NR4A1 -990 1085
NSL1 2427 2273
NSMAF -1013 3345
NTRK1 -1442 7049
NTSR1 3641 5436
NUDC -1820 5032
NUF2 -725 1198
NUMB 4658 5039
NUP107 -3568 6301
NUP133 -2062 935
NUP160 -3599 1293
NUP37 -837 3398
NUP43 -3605 6346
NUP85 -1286 4518
NUP98 2030 -747
OBSCN -3754 191
OPN3 1536 3803
OPRL1 4530 -1822
OS9 4446 -313
OSBPL11 4000 5620
OTUD3 -2247 5747
OTUD7B -2248 42
OTULIN -208 6432
P2RY1 4657 3720
P2RY2 2380 -485
P4HB 3946 5718
PAFAH1B1 2858 6858
PAG1 2103 6279
PAK1 3920 2452
PAK2 3401 283
PAK4 -149 3938
PAQR3 -732 2041
PARD6A -1805 4619
PARP1 -3618 3582
PCSK5 2119 -869
PDE1B 4095 -1314
PDE2A 966 -1910
PDE3B -4043 3507
PDE4A 2648 -975
PDE4B -3305 -866
PDE4C 2134 -932
PDE4D 1338 1999
PDE5A 584 3824
PDE6B -3818 1268
PDE6D 1683 4822
PDE7A -4293 5613
PDE7B 263 7263
PDE8A 1890 5316
PDHB -929 560
PDHX -75 4892
PDK1 -308 1824
PDK2 -2386 3785
PDPK1 3242 346
PEA15 -2028 7145
PEAK1 1686 4365
PEBP1 -4438 4325
PELP1 -3537 2742
PFN1 3107 3814
PFN2 -4035 6353
PGF 485 -1150
PGRMC2 -4203 -310
PHB -2519 4542
PHC1 -3734 -1213
PHC2 4552 4887
PHC3 -883 4977
PHIP 372 3484
PHLPP1 2814 5441
PHLPP2 -4321 6881
PICALM 4026 -1233
PIK3AP1 4412 1373
PIK3CA 749 1470
PIK3CD 3357 6109
PIK3CG 3446 2051
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R3 943 3645
PIK3R4 -767 2170
PIK3R5 2731 4483
PIN1 214 4014
PIP4K2A 144 3045
PIP4K2B -2458 1071
PIP4K2C 386 223
PIP5K1A 2157 4436
PIP5K1C 2803 3895
PKN1 2191 6604
PKN2 154 1740
PKN3 1023 6035
PKP4 -1546 -659
PLCB2 2728 903
PLCB3 4631 -1268
PLCG1 -4193 958
PLCG2 4027 2803
PLD1 4524 -902
PLEKHG2 4537 4272
PLEKHG3 -770 -1855
PLIN3 4647 23
PLK1 1850 3514
PLXND1 4289 -1845
PMEPA1 -3406 7048
PMF1 -289 6313
PML -294 4575
POFUT1 2711 3622
POLR2A 2854 4046
POLR2B -1272 5563
POLR2C -184 6356
POLR2D -2801 -614
POLR2E 1754 3712
POLR2F 1457 509
POLR2G 1427 1604
POLR2H -2461 6299
POLR2I -1497 5657
POLR2K -1891 3853
POU2F1 2852 3909
PPARD -3366 -791
PPM1A 3338 -136
PPP1CA 2035 4238
PPP1CB 2372 -340
PPP1CC 196 5379
PPP1R12A 2826 4510
PPP1R12B 3153 4895
PPP1R15A 867 829
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5A 3798 -230
PPP2R5B 3843 -286
PPP2R5C -2002 7074
PPP2R5D 2308 3470
PPP2R5E -960 1402
PPP3CA 1228 5980
PPP3CB 2123 4044
PPP3CC -3985 2384
PPP3R1 1915 2945
PPP5C -1295 5721
PRC1 838 4462
PRDM4 -2075 6116
PREX1 4356 5229
PRKAA1 841 607
PRKAB1 2545 -840
PRKAB2 -2142 3091
PRKACA 4651 890
PRKACB -4452 1712
PRKAG1 2830 -1055
PRKAG2 -691 1021
PRKAR1A 4198 -432
PRKAR1B 1950 1230
PRKAR2A 2666 -874
PRKCA -898 6894
PRKCB 3189 4964
PRKCD 4562 6360
PRKCE 3011 -1185
PRKCH -4304 2578
PRKCI -2065 1662
PRKCQ -4200 4208
PRKCZ -2369 -1376
PRMT1 -3615 2118
PROK2 4461 -1991
PRR5 -2760 -347
PSAP 3330 628
PSEN1 4153 4955
PSEN2 -2556 -162
PSENEN 2520 4980
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
PTBP1 -1053 815
PTCH1 -980 5608
PTCH2 -1346 -566
PTEN 3653 4815
PTGER2 705 -850
PTGER4 -1413 5866
PTGES3 -1846 4287
PTK2 147 -475
PTK2B 4572 4529
PTPN1 4262 699
PTPN11 2272 5062
PTPN12 2791 -982
PTPN13 -2382 6850
PTPN18 4432 3436
PTPN2 3465 181
PTPN6 4161 6542
PTPN7 -233 2323
PTPRA 1697 6358
PTPRJ 4090 7170
PTPRU 2683 -1728
PXN 3967 -814
PYGO2 -3659 6530
QRFP 1354 -1964
RAB4A -608 559
RAB4B 3134 4688
RAB6A 3874 3323
RAB7A 3957 -124
RAC1 4263 5541
RAC2 3032 4577
RAC3 -984 827
RACGAP1 2043 4089
RAD21 -1195 5118
RAF1 3715 6573
RALA -2555 2302
RALB 3954 6833
RALBP1 2577 5392
RALGAPA1 -2428 4578
RALGDS -3104 6406
RANBP10 1673 5496
RANBP2 -405 5165
RANBP9 2458 884
RANGAP1 -3743 3626
RAP1A 2631 6569
RAP1B 2468 5968
RAP1GDS1 -1934 3444
RAPGEF1 1750 6445
RARA 4372 2132
RARG -1393 297
RASA1 2167 3434
RASA2 302 2632
RASA3 -4133 187
RASAL1 -237 5685
RASAL3 -2529 2544
RASGRP1 -4180 5888
RASGRP2 -2424 -413
RASGRP3 -2744 760
RBBP4 -2172 4061
RBBP5 -378 2829
RBBP6 -2144 2861
RBCK1 3143 -510
RBL1 -2914 5256
RBPJ 3988 1033
RBX1 1356 5883
RCC2 1175 1985
RCE1 -1246 3297
RCOR1 4251 -178
RDH10 -1648 262
RDH11 968 4047
RDH13 425 -1151
RDH14 -4468 1087
RELA -73 4333
REST 517 1286
RGL1 4337 3381
RGL2 3842 4879
RGS1 -2398 4458
RGS10 -1275 1143
RGS12 313 4990
RGS14 2975 1881
RGS16 -3037 2518
RGS19 3937 -154
RGS2 3007 3106
RGS3 3464 7122
RHEB 1519 6311
RHOA 3580 4033
RHOB 2885 2346
RHOBTB2 -2966 2104
RHOBTB3 -1367 1297
RHOF -3792 6478
RHOG 4271 3664
RHOH -4090 5999
RHOQ 993 -160
RHOT1 4525 5576
RHOT2 -820 5894
RHPN1 -4176 852
RICTOR -2029 2833
RING1 -1409 1003
RIT1 4306 2694
RND1 1278 780
RNF111 2486 6049
RNF146 4444 1611
RNF2 95 2513
RNF20 2275 4638
RNF31 -31 3198
RNF41 4047 4402
ROCK1 3235 2732
RPGRIP1L -3805 2731
RPS27A -4373 2589
RPS6 -4362 361
RPS6KA1 4529 -1859
RPS6KA2 1506 2117
RPS6KA5 -4174 1991
RPS6KB2 1007 4805
RPTOR -402 5596
RRAGA 3399 6806
RRAGC 605 5284
RRAGD 3035 -1656
RRAS2 -1753 6336
RTN4 4490 2901
RUNX1 4212 193
RUNX3 -2741 6760
RUVBL1 -3465 4751
RYK -4192 4958
S1PR1 -1593 6791
S1PR2 -2407 3081
S1PR4 2766 5358
SAMM50 -1638 6081
SAV1 -1222 -1156
SCAI -2334 1276
SCD 2394 -1082
SCMH1 -3931 95
SCRIB 962 -1418
SEC13 2700 6211
SEH1L -4285 3577
SEL1L 2866 4058
SEMA4F -3691 5605
SENP1 667 1369
SFN 639 -1779
SFPQ -1664 3947
SGK1 -2490 -1194
SH2B1 -2131 1436
SH2B3 2353 3851
SH2D2A -2483 6509
SH3BP1 688 7100
SH3GL1 3692 6040
SH3PXD2A -3822 469
SHARPIN 2972 4878
SHB 4083 6644
SHC1 3650 3205
SHKBP1 4508 4503
SHMT2 -1092 1900
SHOC2 2120 34
SIRT6 2704 6645
SKA2 -2125 2113
SKI -1509 2897
SKIL 2418 3946
SKP1 -2513 2680
SLC1A5 1690 -1350
SLC38A9 1891 6117
SLC4A7 -3313 6615
SLK 2109 -1625
SMAD1 4662 206
SMAD2 2180 1865
SMAD3 -3344 -363
SMAD4 -1376 -1925
SMAD5 -1208 221
SMAD6 4373 5259
SMAD7 25 1420
SMARCA4 2865 6792
SMC3 -2408 623
SMPD2 1410 6784
SMPD3 -2725 7226
SMURF1 2253 6934
SMURF2 -2298 3523
SNAP23 2713 -471
SNW1 1166 2517
SOCS1 1609 4130
SOCS3 4385 6492
SOS1 -1111 -1986
SOS2 3749 3699
SOX4 2349 4439
SP1 3722 4865
SPATA13 1302 5997
SPC24 974 3603
SPDL1 -4239 480
SPEN 2503 3750
SPOP -1585 39
SPOPL 2817 -1205
SPPL2A 3431 1613
SPPL2B -1677 4261
SPRED1 1227 6065
SPRED2 4192 5462
SPRED3 745 5938
SPRY1 -451 2310
SPRY2 1327 1690
SPTAN1 -4222 -407
SPTBN1 -3485 3657
SPTBN5 1628 2256
SQSTM1 -748 658
SRC -2558 -1476
SREBF1 798 2475
SRF 3509 2816
SRGAP1 3894 -15
SRGAP3 848 -351
SRRM1 -799 3813
ST3GAL3 -2022 5837
ST3GAL4 4013 -1351
ST3GAL6 1125 6719
STAG1 -1549 5283
STAM 314 6491
STAM2 2669 3301
STARD13 1507 7249
STAT1 -4215 4970
STAT3 3745 4995
STAT5A 2844 -1545
STAT5B 3260 1495
STAT6 3810 3854
STBD1 1952 -658
STIP1 -1241 362
STK10 3375 -688
STK11 -81 750
STK3 3729 265
STK38 2310 46
STK4 724 -11
STMN1 -3244 3009
STOM 2913 -1586
STRADA 2763 3716
STRADB 2048 1425
STRAP 697 5452
STRN 2512 6485
STUB1 -996 2320
STX5 3177 5926
SUFU 4546 3621
SYDE2 -4274 6281
SYK 4033 431
SYNGAP1 -3312 1191
SYVN1 1964 -846
TAB2 693 6401
TACC3 3473 5485
TAGAP -4528 3486
TAOK1 2906 7113
TAOK3 2220 118
TAX1BP1 1803 1037
TBL1XR1 1666 2633
TCF12 833 -542
TCF7 -4594 6951
TCF7L2 4350 1660
TCIRG1 4550 1353
TEC 3772 170
TERT -1838 7281
TEX2 3522 -1026
TFDP1 3228 2953
TFDP2 -3622 -1478
TFRC 1662 -131
TGFA 4463 4632
TGFB1 1897 3769
TGFBR1 1701 -1264
TGFBR2 2002 2870
TGIF1 -2836 -390
TGIF2 -3817 -1905
THBS3 2900 -662
THEM4 -4578 809
TIA1 -1428 2854
TIAL1 -1725 5521
TIAM2 1135 -1147
TJP2 4171 4717
TLE2 -4474 1969
TLE3 4587 3113
TLE4 4122 5138
TLN1 3997 -983
TLR9 -10 7204
TMED2 1834 5946
TMED5 2850 1678
TMEM59 2575 2439
TMEM87A -931 -1318
TMOD3 3670 6415
TMPO 3164 5174
TNF -477 -526
TNFAIP1 4420 3483
TNFAIP3 -842 6105
TNFRSF10A -1036 2821
TNFRSF10B 3351 -670
TNFRSF10D 2443 3086
TNFRSF1A 4465 -1548
TNFSF10 2 369
TNKS 9 4477
TNKS2 1218 2960
TNRC6A 119 5197
TNRC6B 110 7059
TOR1AIP1 2516 4215
TP53 -4050 2709
TPM3 3905 6505
TPM4 3236 633
TRADD -3052 5248
TRAF1 -3840 6215
TRAF2 -3119 5765
TRAF6 1605 -71
TRAK2 -1938 -32
TRIB3 875 3767
TRIM27 4077 5498
TRIM33 -169 6680
TRIO 1657 6818
TRRAP -387 6328
TSC1 479 4696
TSC2 1480 3951
TTC21B -2547 3389
TUBA1B 3004 4760
TULP3 -3633 3709
TWF1 1266 2316
TXNL1 1509 5743
TYK2 4387 4072
UBA52 -1313 -69
UBB 355 5059
UBC 2129 3220
UBE2D1 3526 2741
UBE2D3 3214 3005
UBE2M 2658 2052
UBXN11 987 2973
UCHL5 -3365 2394
UHMK1 -667 4668
UHRF1BP1L 3841 723
USF1 2393 3193
USF2 2091 1718
USP13 -515 2905
USP15 1312 4187
USP21 -1473 -293
USP34 414 1573
USP4 4312 -254
USP7 2170 3259
USP8 2559 4109
VAMP3 3540 619
VAPA 3695 4246
VAPB -204 -1989
VAV1 4015 5834
VAV2 975 4134
VAV3 3114 -685
VCL 2144 3614
VCP 2829 1908
VEGFA 1946 87
VHL 930 5209
VIM 4470 3780
VIPR1 -3085 5973
VPS26A 2139 4070
VPS29 1235 688
VPS35 2381 -1447
VRK2 174 2179
VRK3 2567 2903
WASF1 4637 -830
WASF2 4371 -134
WASL 1150 4645
WDR11 1068 3347
WDR19 -3355 -150
WDR35 -1881 -219
WDR6 -2270 -476
WDR81 -573 3580
WDR83 2059 5497
WDR91 -1280 5673
WHAMM -3526 2748
WIPF1 1102 -784
WIPF2 3237 -1018
WNT1 -2165 2325
WNT2B 1472 3566
WWOX -3993 4712
WWP1 -4510 479
WWP2 4357 2916
XPO1 -1207 6847
YBX1 847 6425
YES1 -1057 5198
YKT6 2749 3314
YWHAB 1621 2152
YWHAE 3368 1288
YWHAG 4167 1919
YWHAH 3924 -1276
YWHAQ -1781 3225
YWHAZ 1788 4294
YY1 -1982 1468
ZAP70 -3837 7251
ZDHHC21 -2644 427
ZDHHC7 3096 4796
ZFYVE16 3455 4517
ZFYVE9 -4386 3529
ZNF217 1954 2921
ZNRF3 -1990 3859
ZW10 -230 -591
ZWILCH -1791 835
ZWINT -1706 6104



Metabolism of RNA

Metabolism of RNA
metric value
setSize 535
pMANOVA 5.95e-25
p.adjustMANOVA 6.28e-23
s.dist 0.277
s.RNA -0.259
s.meth 0.0964
p.RNA 4.75e-24
p.meth 0.000177




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
NUP88 -4340 7084
RPL3 -4497 6753
RPS2 -4297 6975
TSR1 -4374 6839
GEMIN4 -4334 6849
NDC1 -4564 6482
RPL34 -4236 6515
UPF3A -3854 6963
RPS12 -4108 6331
RPLP2 -4046 6423
SNU13 -3683 7054
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
QTRT1 -4151 5789
SNRNP40 -3823 6269
RPS15A -3897 6112
EXOSC2 -4396 5344

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1256 1467
ACTB 4254 5447
ADAR 2571 3087
ADARB1 -981 -972
ADAT1 -469 5559
ADAT2 -3208 3497
ADAT3 1791 6334
AKT1 2261 1109
ALKBH8 -4507 5003
ALYREF -801 6737
ANP32A 3983 1765
AQR 1035 -1471
BMS1 -4317 -1755
BUD31 2023 2740
BYSL -1886 6808
C1D -117 2322
C2orf49 -1930 2636
CASC3 3679 5106
CCAR1 -1335 4000
CCNH 723 1260
CD2BP2 2921 -544
CD44 3510 4898
CDC40 1743 7125
CDC5L 1468 -742
CDK7 1419 4034
CDKAL1 -2311 4217
CHERP -675 2907
CLNS1A -3223 -278
CLP1 1923 2378
CNOT1 1452 4959
CNOT10 -991 3018
CNOT11 494 3729
CNOT3 3178 3093
CNOT4 1065 6001
CNOT6 2589 4653
CNOT6L -3586 6262
CNOT7 -3901 -58
CNOT8 980 5798
CPSF1 -206 1083
CPSF2 2562 988
CPSF3 2618 5337
CPSF4 -1537 1770
CRNKL1 557 5505
CSNK1D 3147 3046
CSNK1E -2625 3000
CSTF1 -3014 6209
CTNNBL1 1359 2615
CTU1 1806 4162
CTU2 -1858 7026
CWC15 -777 -1127
CWC22 -1302 4010
CWC27 46 -818
DCAF13 -3178 862
DCP1A -1860 5069
DCP1B -3895 2554
DCP2 2460 5677
DCPS 701 5060
DDX1 -2761 2193
DDX20 -4033 3954
DDX21 -423 3312
DDX23 1682 2707
DDX42 633 1669
DDX46 97 2158
DDX47 -4147 -50
DDX49 1400 5582
DDX5 -2667 1804
DDX52 621 -204
DDX6 -45 2014
DHX16 774 3127
DHX37 -1827 4195
DHX9 -1435 5547
DIS3 -1584 -754
DNAJC8 -856 861
DUS2 1005 710
EBNA1BP2 -3371 6235
EDC3 2197 3531
EDC4 -1096 -1378
EFTUD2 3136 2652
EIF4A1 1909 881
EIF4A2 -4298 3601
EIF4A3 509 4598
EIF4B -3517 5587
EIF4E 577 6721
EIF4G1 4196 5766
ELAC2 -2081 275
ELAVL1 -1165 1665
ENPP2 1904 3897
ERCC2 2316 1849
ERCC3 1189 1487
ERI1 2342 -139
ETF1 2407 151
EXOSC1 -183 316
EXOSC10 -2785 802
EXOSC2 -4396 5344
EXOSC3 -12 3245
EXOSC4 3917 64
EXOSC5 -3620 790
EXOSC6 -3115 1534
EXOSC7 -3669 -158
EXOSC8 -4171 1364
FAM98B -2184 2205
FAU -1368 6877
FBL -4488 -43
FCF1 169 6763
FIP1L1 -668 3099
FTSJ3 -424 4236
FUS -1474 5262
FYTTD1 -2696 5127
GAR1 -3086 879
GCFC2 -4365 -1741
GEMIN2 -1270 -290
GEMIN4 -4334 6849
GEMIN5 -1635 1695
GEMIN6 -1739 -1086
GEMIN7 5 -388
GLE1 3506 1687
GNL3 -4499 1201
GSPT1 -741 -1155
GTF2F1 2368 558
GTF2F2 2169 5307
GTF2H3 -3711 5705
GTF2H4 -291 5240
GTF2H5 -620 3417
GTPBP3 -3170 1640
HBS1L -190 598
HEATR1 -3022 5201
HNRNPA0 -3670 3059
HNRNPA2B1 1073 2721
HNRNPC 1462 213
HNRNPD -1456 -667
HNRNPF 452 5857
HNRNPH1 -3044 2373
HNRNPK 1903 3141
HNRNPL 1768 6119
HNRNPM 1556 2773
HNRNPR -3649 4903
HNRNPU 507 4167
HNRNPUL1 1207 2869
HSPA1A 3554 -920
HSPB1 -556 883
IGF2BP3 1544 -734
IMP3 -2832 5542
IMP4 -2963 3786
ISG20L2 1107 6438
ISY1 292 1885
KHSRP 406 1774
KRR1 -3265 -1952
LCMT2 -2552 6264
LSM1 454 5934
LSM10 2249 1062
LSM11 -3997 -211
LSM2 -1 5948
LSM3 -1306 2560
LSM4 -3325 -239
LSM5 -4069 4274
LSM6 1527 2778
LSM7 -3407 689
LSM8 -3131 -1736
LTV1 -2942 2915
MAPK14 4535 2465
MAPKAPK2 3308 3265
METTL1 -4426 4406
METTL14 -848 -834
MNAT1 -2524 1516
MPHOSPH10 -3876 5401
MPHOSPH6 -1196 5535
MRM1 -3703 -159
MTERF4 -4478 3503
MTO1 -2888 396
NCBP1 -340 5859
NCBP2 -4320 4777
NCL -4149 5054
NDC1 -4564 6482
NHP2 -2631 4827
NIP7 -3295 4219
NOB1 -3907 2003
NOC4L 554 -799
NOL11 -4484 2571
NOL12 1466 -1551
NOL6 -3321 4557
NOL9 -3852 -1446
NOP10 4120 2081
NOP14 -4322 2209
NOP2 -3578 6403
NOP56 -4212 996
NOP58 -4541 1333
NSUN2 436 2230
NSUN4 811 3316
NSUN6 37 2767
NUDT21 -3302 4271
NUP107 -3568 6301
NUP133 -2062 935
NUP153 96 4344
NUP155 -2910 3043
NUP160 -3599 1293
NUP188 -3388 2922
NUP205 -3151 1670
NUP210 -1503 690
NUP214 3964 4369
NUP35 -4376 -557
NUP37 -837 3398
NUP43 -3605 6346
NUP50 935 6706
NUP54 -2949 831
NUP62 -899 4609
NUP85 -1286 4518
NUP88 -4340 7084
NUP93 -2587 2006
NUP98 2030 -747
NXF1 2005 1236
NXT1 -3804 4713
PABPC1 -1115 3011
PABPN1 -645 3061
PAIP1 -1829 6167
PAN2 -320 -743
PAN3 864 1365
PAPOLA 1833 4317
PARN -1502 5479
PATL1 3947 -473
PCBP1 2767 865
PCBP2 90 3201
PDCD11 -2635 3455
PDCD7 -2260 3569
PELP1 -3537 2742
PES1 -2958 3288
PHAX -3500 5545
PLRG1 -2965 5211
PNO1 -3412 6496
PNRC2 -1416 5678
POLDIP3 3991 3182
POLR2A 2854 4046
POLR2B -1272 5563
POLR2C -184 6356
POLR2D -2801 -614
POLR2E 1754 3712
POLR2F 1457 509
POLR2G 1427 1604
POLR2H -2461 6299
POLR2I -1497 5657
POLR2K -1891 3853
POM121 -48 4681
POM121C -623 2061
POP1 -2188 3613
POP4 26 1072
POP5 -3324 5989
POP7 -520 3070
PPIE -2531 6027
PPIH -3964 2129
PPIL1 -3051 -1626
PPIL3 -2102 375
PPIL4 -966 -164
PPIL6 1876 147
PPP2CA 2390 2598
PPP2R2A 619 -752
PPWD1 -3070 -1685
PRCC 1796 2255
PRKCA -898 6894
PRKCD 4562 6360
PRMT5 542 2005
PRPF19 -3477 6017
PRPF3 -1463 1089
PRPF31 -1859 3855
PRPF38A -66 5306
PRPF40A 128 5628
PRPF6 -2484 4285
PRPF8 -1466 516
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
PTBP1 -1053 815
PUF60 -636 2049
PUS1 -3238 4830
PUS3 403 965
PUS7 -4089 5387
PWP2 -2097 5076
QTRT1 -4151 5789
RAE1 1714 2634
RAN -3671 1483
RANBP2 -405 5165
RBM17 -3530 2268
RBM28 -2232 3412
RCL1 -3250 6343
RIOK1 -1870 6498
RIOK2 -3453 1638
RIOK3 2518 3472
RNGTT 1383 14
RNMT -3181 6871
RNPC3 -1529 3737
RNPS1 -3428 537
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPP14 -809 2236
RPP21 -1630 2599
RPP25 -3799 5745
RPP30 -3771 668
RPP38 -3246 4780
RPP40 -4559 570
RPPH1 4152 5012
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
RRP1 -1139 5200
RRP7A -2020 1582
RRP9 -3748 653
RTCB -167 -1473
SART1 2350 5777
SEC13 2700 6211
SEH1L -4285 3577
SENP3 36 5394
SET -3297 -1667
SF1 256 2873
SF3A1 38 6187
SF3A2 -2259 7185
SF3A3 -3728 4521
SF3B2 1201 2483
SF3B3 -3699 423
SF3B4 1224 1093
SF3B5 -354 2879
SKIV2L 1380 6259
SLBP -1040 428
SLU7 134 1094
SMG1 -180 4789
SMG5 1671 5173
SMG6 -173 6207
SMG7 4117 2361
SMG8 1710 1691
SMNDC1 986 3512
SNRNP200 -1911 1391
SNRNP25 -728 2891
SNRNP27 753 1452
SNRNP35 2033 -1468
SNRNP40 -3823 6269
SNRNP48 -1736 -1045
SNRNP70 -3261 2532
SNRPA -15 1269
SNRPA1 -3010 1539
SNRPB -1600 4948
SNRPB2 -1257 1876
SNRPC -1137 3152
SNRPD1 -2724 4845
SNRPD2 -3169 -551
SNRPD3 -2538 -377
SNRPE -3729 3730
SNRPG 210 3411
SNRPN -3723 -1424
SNU13 -3683 7054
SNUPN 552 2739
SNW1 1166 2517
SRRM1 -799 3813
SRRM2 359 -214
SRRT -2226 1308
SRSF10 -3868 2085
SRSF11 -3950 -51
SRSF2 -2454 212
SRSF3 -2156 -1225
SRSF4 2517 6867
SRSF7 -2997 618
SRSF9 3244 745
SUPT5H -1388 2020
SYF2 384 4212
SYMPK 402 2886
TBL3 262 5418
TEX10 -3909 1204
TFB1M -2804 1831
TFIP11 1573 936
THADA -2729 4244
THG1L -3084 2917
THOC1 -3385 6023
THOC5 4072 3364
THOC7 130 5594
THUMPD1 -4407 -871
TNFSF13 3950 -1364
TNKS1BP1 -3635 3401
TNPO1 850 4635
TP53RK -3369 2847
TPR -1423 4616
TPRKB -3323 3473
TRDMT1 -300 -401
TRIT1 -2067 6755
TRMT1 -2564 -744
TRMT10A 2447 1313
TRMT11 -4248 2032
TRMT112 -847 1929
TRMT12 -679 -1653
TRMT44 -1992 -1516
TRMT6 3036 3940
TRMT61A -2917 3423
TRMT61B -4100 5388
TRMU -2043 6387
TRNT1 -2149 4675
TSEN15 -3695 502
TSEN2 -3851 3306
TSEN34 3598 1820
TSEN54 -3253 591
TSR1 -4374 6839
TSR3 505 6370
TTC37 -2973 334
TXNL4A 1980 2176
TYW1 -4163 2393
TYW3 -4074 985
TYW5 500 3607
U2AF1 2203 1030
U2AF1L4 -793 5616
U2AF2 177 6132
U2SURP -1738 6592
UBA52 -1313 -69
UBB 355 5059
UBC 2129 3220
UPF1 3435 5958
UPF2 443 3840
UPF3A -3854 6963
URM1 -628 3783
USP39 1440 5626
UTP15 -4042 5063
UTP18 1320 3357
UTP20 -3101 5085
UTP3 -1850 3926
UTP6 -3759 3932
WBP11 -3492 986
WBP4 1339 1882
WDR12 -266 6794
WDR18 -1452 -1078
WDR3 -2885 -1387
WDR33 -170 3468
WDR36 -1954 6601
WDR43 -4181 5510
WDR61 -887 1522
WDR75 -4429 4614
WDR77 -3970 2831
WTAP 925 3489
XAB2 162 1760
XPO1 -1207 6847
XPOT -2210 2981
XRN1 -797 -1961
XRN2 4041 -29
YBX1 847 6425
YWHAB 1621 2152
YWHAZ 1788 4294
ZBTB8OS 1375 266
ZCRB1 -924 438
ZFP36 1866 5100
ZFP36L1 3148 5471
ZMAT5 3234 6884



Translation

Translation
metric value
setSize 234
pMANOVA 6.93e-25
p.adjustMANOVA 6.7e-23
s.dist 0.404
s.RNA -0.402
s.meth 0.0472
p.RNA 5.81e-26
p.meth 0.217




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
MRPS9 -3911 5774
MRPL48 -3884 5773
RPS16 -3735 5981
RPS29 -3769 5602
MRPL39 -3379 6177
SRPRB -3153 6605
RPL23A -4508 4560
RPL13 -3240 6189

Click HERE to show all gene set members

All member genes
RNA meth
AARS2 -3545 952
AIMP2 -1261 5643
APEH 1694 832
AURKAIP1 1982 4899
CARS2 3223 3857
CHCHD1 1254 5961
DAP3 -2924 3981
DARS2 1044 -1324
EARS2 -3727 -610
EEF1A1 -4394 2941
EEF1B2 -4380 3976
EEF1D -2214 5791
EEF1E1 -1004 -948
EEF1G -4126 111
EEF2 -2501 4196
EIF2B1 -819 6669
EIF2B2 2695 -173
EIF2B3 -2697 1141
EIF2B4 1474 3641
EIF2B5 -2167 5042
EIF2S1 -597 4745
EIF2S2 208 6254
EIF3A -452 5855
EIF3B -4255 -704
EIF3E -3975 503
EIF3F -2004 1471
EIF3G -1016 3038
EIF3H -2928 3706
EIF3I -957 696
EIF3J -2581 737
EIF3K -877 6636
EIF3L -3550 2568
EIF3M -2777 5836
EIF4A1 1909 881
EIF4A2 -4298 3601
EIF4B -3517 5587
EIF4E 577 6721
EIF4EBP1 1003 4398
EIF4G1 4196 5766
EIF4H 2816 -1988
EIF5 1036 4313
EIF5B -2807 4183
ERAL1 -496 5758
ETF1 2407 151
FARS2 -4281 2999
FARSA -194 3072
FARSB -3736 2500
FAU -1368 6877
GADD45GIP1 -1038 351
GFM1 -4226 1128
GFM2 524 4209
GSPT1 -741 -1155
HARS2 984 2446
IARS2 -575 3733
LARS2 -2494 -1562
MARS2 -3390 951
MRPL1 -3200 452
MRPL10 1420 -1245
MRPL11 -2123 3156
MRPL12 -1454 5433
MRPL13 -80 1510
MRPL14 -2737 -354
MRPL15 -1108 5966
MRPL16 -657 350
MRPL18 -1249 4037
MRPL19 -1578 1189
MRPL2 -913 -1977
MRPL20 -596 -1814
MRPL21 -918 1490
MRPL22 -163 -877
MRPL23 1672 -547
MRPL24 -3802 1499
MRPL27 -1631 5382
MRPL30 -901 5642
MRPL32 -3408 2250
MRPL33 934 110
MRPL34 -1834 4947
MRPL35 -2345 2146
MRPL36 572 6690
MRPL37 72 4357
MRPL38 -3140 -344
MRPL39 -3379 6177
MRPL4 -693 6863
MRPL41 -1292 1121
MRPL42 -2994 1175
MRPL43 -1702 1544
MRPL44 643 -911
MRPL45 -2871 5889
MRPL46 -3673 2383
MRPL47 -776 4371
MRPL48 -3884 5773
MRPL49 -2183 4584
MRPL50 -4132 2815
MRPL51 921 -1091
MRPL52 1374 1666
MRPL53 2320 940
MRPL54 -2182 3949
MRPL55 -1329 1428
MRPL57 -1942 -1250
MRPL9 -2977 -787
MRPS10 -1007 -184
MRPS11 736 2490
MRPS12 -2205 -442
MRPS14 -2730 4424
MRPS15 -330 4305
MRPS16 132 730
MRPS17 -2830 1178
MRPS18A 480 255
MRPS18B -3480 -1837
MRPS18C -788 3763
MRPS2 -3001 -101
MRPS21 -2520 1336
MRPS22 -886 2961
MRPS23 -1617 -991
MRPS24 364 3928
MRPS25 -4114 175
MRPS26 -2101 6275
MRPS27 -4034 -258
MRPS28 -2487 3988
MRPS30 -3555 4772
MRPS31 -1477 407
MRPS33 -4210 1674
MRPS34 -811 5239
MRPS35 -1250 1580
MRPS36 -182 2055
MRPS5 872 406
MRPS6 -4436 3007
MRPS7 -2711 1187
MRPS9 -3911 5774
MTFMT 1571 2857
MTIF2 -1127 886
MTIF3 85 2044
MTRF1L 1846 2350
N6AMT1 -4117 62
NARS2 -4385 3408
OXA1L 634 4016
PABPC1 -1115 3011
PARS2 316 198
PPA1 -2353 4284
PPA2 -915 1044
PTCD3 -2612 1340
RARS2 -1448 4009
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPN1 2547 6053
RPN2 3320 5501
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
SARS2 -3375 4936
SEC11A 2324 5768
SEC11C -2384 4501
SEC61A1 2689 421
SEC61A2 -2056 301
SEC61B 1487 6424
SEC61G -1179 1928
SPCS2 -353 6694
SPCS3 689 1497
SRP14 1720 5764
SRP19 -229 5846
SRP54 2878 4032
SRP68 277 4340
SRP72 -1341 307
SRPRB -3153 6605
SSR1 393 3856
SSR2 -1085 -133
SSR3 883 -75
TARS2 282 2530
TRAM1 -2599 906
TRMT112 -847 1929
TSFM -2403 3207
TUFM 1203 4618
UBA52 -1313 -69
VARS2 -1378 579
WARS2 -3210 3747
YARS2 -1936 2463



L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
metric value
setSize 85
pMANOVA 1.43e-23
p.adjustMANOVA 1.25e-21
s.dist 0.655
s.RNA -0.627
s.meth 0.19
p.RNA 1.68e-23
p.meth 0.00247




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
EIF4B -3517 5587
RPS3 -4130 4599
RPL37 -3340 5393

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 -597 4745
EIF2S2 208 6254
EIF3A -452 5855
EIF3B -4255 -704
EIF3E -3975 503
EIF3F -2004 1471
EIF3G -1016 3038
EIF3H -2928 3706
EIF3I -957 696
EIF3J -2581 737
EIF3K -877 6636
EIF3L -3550 2568
EIF3M -2777 5836
EIF4A1 1909 881
EIF4A2 -4298 3601
EIF4B -3517 5587
EIF4E 577 6721
EIF4G1 4196 5766
EIF4H 2816 -1988
FAU -1368 6877
PABPC1 -1115 3011
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
UBA52 -1313 -69



GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
metric value
setSize 86
pMANOVA 1.51e-23
p.adjustMANOVA 1.25e-21
s.dist 0.651
s.RNA -0.621
s.meth 0.195
p.RNA 2.26e-23
p.meth 0.00178




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
EIF4B -3517 5587
RPS3 -4130 4599
RPL37 -3340 5393

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 -597 4745
EIF2S2 208 6254
EIF3A -452 5855
EIF3B -4255 -704
EIF3E -3975 503
EIF3F -2004 1471
EIF3G -1016 3038
EIF3H -2928 3706
EIF3I -957 696
EIF3J -2581 737
EIF3K -877 6636
EIF3L -3550 2568
EIF3M -2777 5836
EIF4A1 1909 881
EIF4A2 -4298 3601
EIF4B -3517 5587
EIF4E 577 6721
EIF4G1 4196 5766
EIF4H 2816 -1988
EIF5 1036 4313
EIF5B -2807 4183
FAU -1368 6877
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
UBA52 -1313 -69



Selenocysteine synthesis

Selenocysteine synthesis
metric value
setSize 68
pMANOVA 1.64e-23
p.adjustMANOVA 1.27e-21
s.dist 0.729
s.RNA -0.705
s.meth 0.184
p.RNA 7.89e-24
p.meth 0.00884




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599
RPL37 -3340 5393
RPS7 -4048 4408

Click HERE to show all gene set members

All member genes
RNA meth
EEFSEC -2608 1972
FAU -1368 6877
PSTK -2230 -729
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
SEPHS2 2957 1949
UBA52 -1313 -69



Viral mRNA Translation

Viral mRNA Translation
metric value
setSize 67
pMANOVA 2.23e-23
p.adjustMANOVA 1.62e-21
s.dist 0.735
s.RNA -0.701
s.meth 0.22
p.RNA 3.21e-23
p.meth 0.0019




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599
RPL37 -3340 5393
RPS7 -4048 4408

Click HERE to show all gene set members

All member genes
RNA meth
DNAJC3 3801 6472
FAU -1368 6877
GRSF1 -1089 4316
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
UBA52 -1313 -69



Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication
metric value
setSize 110
pMANOVA 4.42e-23
p.adjustMANOVA 3.02e-21
s.dist 0.574
s.RNA -0.532
s.meth 0.215
p.RNA 6.25e-22
p.meth 0.000104




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
NUP88 -4340 7084
RPL3 -4497 6753
RPS2 -4297 6975
NDC1 -4564 6482
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
NUP43 -3605 6346
NUP107 -3568 6301
IPO5 -4587 4875
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1256 1467
DNAJC3 3801 6472
FAU -1368 6877
GRSF1 -1089 4316
GTF2F1 2368 558
GTF2F2 2169 5307
HSP90AA1 -1535 6210
IPO5 -4587 4875
NDC1 -4564 6482
NUP107 -3568 6301
NUP133 -2062 935
NUP153 96 4344
NUP155 -2910 3043
NUP160 -3599 1293
NUP188 -3388 2922
NUP205 -3151 1670
NUP210 -1503 690
NUP214 3964 4369
NUP35 -4376 -557
NUP37 -837 3398
NUP43 -3605 6346
NUP50 935 6706
NUP54 -2949 831
NUP62 -899 4609
NUP85 -1286 4518
NUP88 -4340 7084
NUP93 -2587 2006
NUP98 2030 -747
PARP1 -3618 3582
POLR2A 2854 4046
POLR2B -1272 5563
POLR2C -184 6356
POLR2D -2801 -614
POLR2E 1754 3712
POLR2F 1457 509
POLR2G 1427 1604
POLR2H -2461 6299
POLR2I -1497 5657
POLR2K -1891 3853
POM121 -48 4681
POM121C -623 2061
RAE1 1714 2634
RANBP2 -405 5165
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
SEC13 2700 6211
SEH1L -4285 3577
TPR -1423 4616
UBA52 -1313 -69



Eukaryotic Translation Termination

Eukaryotic Translation Termination
metric value
setSize 70
pMANOVA 1.34e-22
p.adjustMANOVA 8.61e-21
s.dist 0.703
s.RNA -0.685
s.meth 0.158
p.RNA 3.69e-23
p.meth 0.0225




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599
RPL37 -3340 5393
RPS7 -4048 4408

Click HERE to show all gene set members

All member genes
RNA meth
APEH 1694 832
ETF1 2407 151
FAU -1368 6877
GSPT1 -741 -1155
N6AMT1 -4117 62
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
TRMT112 -847 1929
UBA52 -1313 -69



Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
metric value
setSize 93
pMANOVA 2.31e-22
p.adjustMANOVA 1.34e-20
s.dist 0.611
s.RNA -0.58
s.meth 0.193
p.RNA 4.63e-22
p.meth 0.00133




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
EIF4B -3517 5587
RPS3 -4130 4599
RPL37 -3340 5393

Click HERE to show all gene set members

All member genes
RNA meth
EIF2B1 -819 6669
EIF2B2 2695 -173
EIF2B3 -2697 1141
EIF2B4 1474 3641
EIF2B5 -2167 5042
EIF2S1 -597 4745
EIF2S2 208 6254
EIF3A -452 5855
EIF3B -4255 -704
EIF3E -3975 503
EIF3F -2004 1471
EIF3G -1016 3038
EIF3H -2928 3706
EIF3I -957 696
EIF3J -2581 737
EIF3K -877 6636
EIF3L -3550 2568
EIF3M -2777 5836
EIF4A1 1909 881
EIF4A2 -4298 3601
EIF4B -3517 5587
EIF4E 577 6721
EIF4EBP1 1003 4398
EIF4G1 4196 5766
EIF4H 2816 -1988
EIF5 1036 4313
EIF5B -2807 4183
FAU -1368 6877
PABPC1 -1115 3011
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
UBA52 -1313 -69



Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
metric value
setSize 93
pMANOVA 2.31e-22
p.adjustMANOVA 1.34e-20
s.dist 0.611
s.RNA -0.58
s.meth 0.193
p.RNA 4.63e-22
p.meth 0.00133




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
EIF4B -3517 5587
RPS3 -4130 4599
RPL37 -3340 5393

Click HERE to show all gene set members

All member genes
RNA meth
EIF2B1 -819 6669
EIF2B2 2695 -173
EIF2B3 -2697 1141
EIF2B4 1474 3641
EIF2B5 -2167 5042
EIF2S1 -597 4745
EIF2S2 208 6254
EIF3A -452 5855
EIF3B -4255 -704
EIF3E -3975 503
EIF3F -2004 1471
EIF3G -1016 3038
EIF3H -2928 3706
EIF3I -957 696
EIF3J -2581 737
EIF3K -877 6636
EIF3L -3550 2568
EIF3M -2777 5836
EIF4A1 1909 881
EIF4A2 -4298 3601
EIF4B -3517 5587
EIF4E 577 6721
EIF4EBP1 1003 4398
EIF4G1 4196 5766
EIF4H 2816 -1988
EIF5 1036 4313
EIF5B -2807 4183
FAU -1368 6877
PABPC1 -1115 3011
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
UBA52 -1313 -69



Membrane Trafficking

Membrane Trafficking
metric value
setSize 436
pMANOVA 7.78e-22
p.adjustMANOVA 4.3e-20
s.dist 0.278
s.RNA 0.278
s.meth -0.00233
p.RNA 7.61e-23
p.meth 0.934




Top 20 genes
Gene RNA meth
CPD 4315 -1840
ARF1 4256 -1821
GALNT2 4414 -1749
CTSZ 3863 -1980
IGF2R 4190 -1659
RIN1 4563 -1288
FTL 3951 -1426
VPS37B 3202 -1611
KIF3C 3567 -1430
YWHAH 3924 -1276
PICALM 4026 -1233
GOLGA2 3585 -1361
TBC1D1 3976 -1099
CCZ1 2013 -1870
CLINT1 1910 -1929
PPP6R1 3468 -1034
BLOC1S1 4367 -817
VPS25 3605 -962
SNX18 4579 -690
DCTN2 4142 -727

Click HERE to show all gene set members

All member genes
RNA meth
AAK1 -1265 2550
ACBD3 698 201
ACTR10 2038 4868
ACTR1A 4067 1932
ACTR2 3331 3844
ACTR3 3319 5952
ADRB2 -1168 2808
AGFG1 4199 4595
AGPAT3 2889 637
AKT1 2261 1109
AKT2 1896 5431
ALS2CL -4529 2557
ANK1 1951 947
ANK3 -3281 1579
ANKRD27 2158 2102
ANKRD28 -2222 548
AP1B1 4407 5783
AP1G1 2623 2214
AP1G2 -1273 -226
AP1M1 3671 1777
AP1S3 -678 1942
AP2A1 4643 -316
AP2M1 3281 3723
AP2S1 2943 6039
AP3B1 2856 3782
AP3S1 2093 6511
AP4B1 -221 1635
AP4E1 1717 1918
AP4M1 2645 6150
AP4S1 -1602 6583
APP 2164 6623
ARCN1 2469 -399
ARF1 4256 -1821
ARF3 3612 274
ARF4 3559 4620
ARF5 3064 -939
ARF6 1056 3741
ARFGAP1 1047 6821
ARFGAP3 2664 724
ARFIP2 -1539 -113
ARFRP1 -1740 6546
ARL1 -1026 2168
ARPC2 3393 2292
ARPC3 3253 3208
ARPC5 3952 2611
ARRB1 1355 -1278
ARRB2 4301 2913
ASPSCR1 -2410 5824
BET1 -2532 1788
BET1L -570 4145
BICD1 -849 2613
BICD2 3727 556
BIN1 -4095 617
BLOC1S1 4367 -817
BLOC1S3 205 6143
BLOC1S6 -789 4818
BNIP1 -2453 4079
C2CD5 -1285 6927
CALM1 -444 4502
CAPZA1 3644 999
CAPZA2 3025 4667
CAPZB 3664 -308
CBL 3838 1012
CCZ1 2013 -1870
CD3D -3572 7274
CD4 -2816 909
CD55 4431 1455
CD59 1454 -1684
CENPE 2054 -74
CHMP2A 4007 5362
CHMP2B 1081 1684
CHMP3 3197 3694
CHMP4A 1206 4138
CHMP4B 3974 5512
CHMP5 3912 4370
CHMP6 2834 2702
CHMP7 -3969 6064
CLINT1 1910 -1929
CLTA 2554 -546
CLTB 2902 -918
CLTC 4062 7259
CLTCL1 3483 4511
CNIH1 -999 6434
COG1 -2901 922
COG2 -2158 -1012
COG3 -800 755
COG4 3110 645
COG5 815 2084
COG6 -2694 3686
COG7 3891 3161
COG8 150 2377
COPA 4203 5455
COPB1 2918 2637
COPB2 3333 3476
COPE 3027 434
COPS2 325 6456
COPS3 450 1714
COPS4 -1011 5826
COPS5 1240 3236
COPS6 -443 782
COPS7A 3243 -66
COPS7B -1410 5099
COPS8 -3874 -1152
COPZ1 153 97
COPZ2 -2356 -1672
CPD 4315 -1840
CSNK1D 3147 3046
CTSC 3524 1311
CTSZ 3863 -1980
CUX1 4623 4795
CYTH1 -3959 6595
CYTH2 1059 2352
CYTH3 -1639 -968
CYTH4 4164 3823
DCTN2 4142 -727
DCTN3 2319 2751
DCTN4 4296 4417
DCTN5 109 6060
DCTN6 2715 6882
DENND1A 2598 3969
DENND1B -1185 7221
DENND1C 820 3359
DENND2C 2762 875
DENND2D -4197 7012
DENND3 4483 2137
DENND4A -925 2736
DENND4B 3344 1004
DENND5A 3781 1439
DENND6A 473 280
DNM1 2083 1607
DNM2 4115 3063
DTNBP1 -1267 284
DVL2 -2195 4884
DYNC1H1 590 4434
DYNC1I2 2356 693
DYNC1LI1 3051 3242
DYNC1LI2 2757 -185
DYNLL1 521 5151
DYNLL2 -1889 -924
EPN1 4307 5034
EPN2 1008 2946
EPS15 2107 -516
EPS15L1 3140 2728
EXOC1 3033 6223
EXOC2 -1752 5978
EXOC3 2627 3757
EXOC4 2245 1729
EXOC5 207 6716
EXOC6 4032 2017
EXOC7 3666 2374
EXOC8 2022 6708
FCHO1 -407 6034
FCHO2 2619 -593
FNBP1 1674 2510
FTH1 2431 3117
FTL 3951 -1426
GABARAP 2510 4039
GABARAPL2 2712 2948
GAK 3487 6665
GALNT2 4414 -1749
GAPVD1 3303 5351
GBF1 2773 4985
GCC1 1360 -1635
GCC2 -2613 3257
GDI2 2462 3343
GGA1 2524 4229
GGA2 -462 4335
GGA3 3155 671
GJD3 4243 -251
GNS 4663 4429
GOLGA1 3419 1794
GOLGA2 3585 -1361
GOLGA4 -1340 775
GOLGA5 2706 -549
GOLGB1 -1527 5355
GOLIM4 3427 2148
GORASP1 3693 -281
GOSR1 -1151 -852
GOSR2 2077 5880
GPS1 -882 6190
GRB2 4326 6241
HBEGF 729 -1007
HGS 3544 4351
HIP1 4202 6522
HIP1R -3753 -20
HPS1 3304 804
HPS4 -2687 4213
IGF2R 4190 -1659
ITSN1 4329 3959
ITSN2 2288 -585
KDELR1 3680 4935
KDELR2 2213 1832
KIAA0319 2877 2703
KIF11 204 1895
KIF13B 3123 2528
KIF15 -567 6309
KIF16B -1779 5965
KIF18A -145 3290
KIF18B 2003 5532
KIF1B 4168 1220
KIF20A 1313 1403
KIF20B -3012 4534
KIF21A -2788 -346
KIF21B 1706 2388
KIF22 -4444 6183
KIF23 1467 805
KIF26B -3063 -1903
KIF27 1756 6076
KIF2A -2793 4006
KIF2C 710 -12
KIF3A -4208 6174
KIF3B 1849 2018
KIF3C 3567 -1430
KIF5B 3015 4670
KIF6 787 2531
KIF9 2389 2418
KIFAP3 -1460 -68
KIFC1 105 1767
KIFC2 -1170 2527
KLC1 3326 4386
KLC2 -2112 1505
KLC4 -1623 4367
LDLR 4270 1548
LDLRAP1 -4523 4896
LMAN1 -3700 5995
LMAN2 3619 6266
LMAN2L 544 1715
LNPEP -414 2406
M6PR -1871 5979
MADD 1104 -1304
MAN1A1 4388 1559
MAN1A2 -1587 3421
MAN1C1 -4490 145
MAN2A1 -1534 2421
MAN2A2 4046 2485
MCFD2 1763 2397
MIA3 -1397 4042
MON1A 252 1152
MON1B 4149 1931
MVB12A 2478 357
MYH9 3495 6146
MYO6 -1328 1793
NAA30 -3156 2646
NAA35 -2745 4714
NAA38 3120 -541
NAPA 2334 3102
NAPB 1116 2662
NAPG 2705 2684
NBAS 488 3732
NECAP1 2051 3774
NECAP2 -1427 3097
NEDD8 2724 -105
OPTN -3624 -509
PACSIN1 -4272 -1068
PACSIN2 4056 6931
PAFAH1B1 2858 6858
PAFAH1B2 2082 2435
PAFAH1B3 -1547 6671
PICALM 4026 -1233
PIP5K1C 2803 3895
PLA2G6 -2968 826
PLIN3 4647 23
POLG 377 3652
PPP6C 751 6979
PPP6R1 3468 -1034
PPP6R3 1282 -1719
PRKAB1 2545 -840
PRKAB2 -2142 3091
PRKAG1 2830 -1055
PRKAG2 -691 1021
PUM1 2628 6662
RAB10 4448 3067
RAB11A 2314 2440
RAB11B 1358 3899
RAB12 -783 -468
RAB14 1884 -378
RAB18 2497 2764
RAB1A 3881 6419
RAB1B 3928 4467
RAB27A 3688 222
RAB30 -3784 2925
RAB33B 1723 5180
RAB35 2709 905
RAB3A 2176 4348
RAB3GAP1 1775 3219
RAB3GAP2 2306 3837
RAB3IP -212 678
RAB43 2415 5468
RAB4A -608 559
RAB5A 2549 3958
RAB5B 3040 1957
RAB5C 3819 797
RAB6A 3874 3323
RAB7A 3957 -124
RAB8A 1901 1826
RAB8B 2800 1101
RABEP1 -1756 6121
RABEPK 2224 5565
RABGAP1 1995 6385
RABGEF1 2951 3772
RAC1 4263 5541
RACGAP1 2043 4089
RALA -2555 2302
RALGAPA2 4244 -284
RALGAPB 734 3710
REPS1 -51 6314
RGP1 2641 -1039
RHOBTB3 -1367 1297
RHOQ 993 -160
RIC1 2764 6857
RIN1 4563 -1288
RINL -527 6131
RINT1 -3942 3453
RPS27A -4373 2589
SAR1B 2437 3060
SBF1 -1192 3727
SCARB2 3699 3550
SCOC -4016 2228
SEC13 2700 6211
SEC16A 3610 4812
SEC22A -3311 2581
SEC22C -1175 5700
SEC23A 2536 1833
SEC23IP 261 1231
SEC24A 3587 4762
SEC24B 2639 -13
SEC24C 3376 -336
SEC24D 4369 1527
SEC31A 1492 2523
SFN 639 -1779
SH3GL1 3692 6040
SNAP23 2713 -471
SNAP29 3459 3148
SNAPIN 2840 1354
SNF8 1860 5287
SNX18 4579 -690
SNX2 2248 186
SPTAN1 -4222 -407
SPTBN1 -3485 3657
SPTBN5 1628 2256
SRC -2558 -1476
STAM 314 6491
STAM2 2669 3301
STX10 4016 5277
STX16 1707 1974
STX17 -3415 -218
STX18 2216 2718
STX4 2492 1609
STX5 3177 5926
STX6 2795 -252
STXBP3 2569 199
SURF4 3061 3679
SYNJ1 4232 2804
SYNJ2 -4139 -505
SYS1 -744 4319
SYT11 2412 4051
SYTL1 -1787 -620
TBC1D1 3976 -1099
TBC1D10A -1440 5672
TBC1D10B 4145 6337
TBC1D10C -3207 6912
TBC1D13 3014 4704
TBC1D14 4533 30
TBC1D15 -1220 5333
TBC1D17 -1654 6199
TBC1D2 4365 647
TBC1D20 1352 1409
TBC1D24 1919 4060
TBC1D4 -4573 4593
TBC1D7 2498 5951
TFRC 1662 -131
TGFA 4463 4632
TGOLN2 4065 5919
TMED10 -1687 3393
TMED2 1834 5946
TMED3 1186 5786
TMED7 1363 -959
TMED9 2934 1623
TMEM115 2141 -632
TMF1 495 1642
TOR1A 3286 5481
TOR1B 3470 -606
TPD52 -3861 5618
TRAPPC1 3425 5233
TRAPPC10 906 6987
TRAPPC12 3763 7029
TRAPPC13 -174 7206
TRAPPC2L -665 1131
TRAPPC3 1526 -470
TRAPPC4 -923 1676
TRAPPC5 1136 29
TRAPPC6A -4264 -1706
TRAPPC6B 455 1818
TRAPPC8 2784 59
TRAPPC9 2284 -816
TRIP11 -1001 5856
TSC1 479 4696
TSC2 1480 3951
TSG101 2874 -488
TXNDC5 -784 -1873
UBA52 -1313 -69
UBAP1 4101 5038
UBB 355 5059
UBC 2129 3220
UBQLN1 1842 2747
ULK1 4556 1
USE1 -1971 654
USO1 849 3424
USP6NL 122 5625
VAMP2 -3788 -1239
VAMP3 3540 619
VAMP4 222 1517
VAMP8 -46 868
VPS25 3605 -962
VPS28 -269 6115
VPS36 -1723 1902
VPS37A 3267 3939
VPS37B 3202 -1611
VPS37C 4135 4035
VPS45 -141 3197
VPS4A 66 3112
VPS51 -3541 -1323
VPS52 1138 5049
VPS53 2209 4288
VPS54 1667 -1404
VTA1 1350 3950
VTI1A 3536 3539
WASL 1150 4645
YKT6 2749 3314
YWHAB 1621 2152
YWHAE 3368 1288
YWHAG 4167 1919
YWHAH 3924 -1276
YWHAQ -1781 3225
YWHAZ 1788 4294
ZW10 -230 -591



Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
metric value
setSize 72
pMANOVA 1.02e-21
p.adjustMANOVA 5.38e-20
s.dist 0.683
s.RNA -0.651
s.meth 0.206
p.RNA 1.3e-21
p.meth 0.00259




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
NCBP2 -4320 4777
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599
RPL37 -3340 5393

Click HERE to show all gene set members

All member genes
RNA meth
EIF4G1 4196 5766
ETF1 2407 151
FAU -1368 6877
GSPT1 -741 -1155
NCBP1 -340 5859
NCBP2 -4320 4777
PABPC1 -1115 3011
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
UBA52 -1313 -69
UPF1 3435 5958



Vesicle-mediated transport

Vesicle-mediated transport
metric value
setSize 442
pMANOVA 1.6e-21
p.adjustMANOVA 8.09e-20
s.dist 0.274
s.RNA 0.274
s.meth 0.00404
p.RNA 1.87e-22
p.meth 0.886




Top 20 genes
Gene RNA meth
CLTC 4062 7259
PACSIN2 4056 6931
HIP1 4202 6522
GRB2 4326 6241
TRAPPC12 3763 7029
TBC1D10B 4145 6337
AP1B1 4407 5783
RAB1A 3881 6419
TGOLN2 4065 5919
RAC1 4263 5541
GAK 3487 6665
COPA 4203 5455
LMAN2 3619 6266
SH3GL1 3692 6040
CUX1 4623 4795
CHMP4B 3974 5512
EPN1 4307 5034
CHMP2A 4007 5362
MYH9 3495 6146
STX10 4016 5277

Click HERE to show all gene set members

All member genes
RNA meth
AAK1 -1265 2550
ACBD3 698 201
ACTR10 2038 4868
ACTR1A 4067 1932
ACTR2 3331 3844
ACTR3 3319 5952
ADRB2 -1168 2808
AGFG1 4199 4595
AGPAT3 2889 637
AKT1 2261 1109
AKT2 1896 5431
ALS2CL -4529 2557
ANK1 1951 947
ANK3 -3281 1579
ANKRD27 2158 2102
ANKRD28 -2222 548
AP1B1 4407 5783
AP1G1 2623 2214
AP1G2 -1273 -226
AP1M1 3671 1777
AP1S3 -678 1942
AP2A1 4643 -316
AP2M1 3281 3723
AP2S1 2943 6039
AP3B1 2856 3782
AP3S1 2093 6511
AP4B1 -221 1635
AP4E1 1717 1918
AP4M1 2645 6150
AP4S1 -1602 6583
APP 2164 6623
ARCN1 2469 -399
ARF1 4256 -1821
ARF3 3612 274
ARF4 3559 4620
ARF5 3064 -939
ARF6 1056 3741
ARFGAP1 1047 6821
ARFGAP3 2664 724
ARFIP2 -1539 -113
ARFRP1 -1740 6546
ARL1 -1026 2168
ARPC2 3393 2292
ARPC3 3253 3208
ARPC5 3952 2611
ARRB1 1355 -1278
ARRB2 4301 2913
ASPSCR1 -2410 5824
BET1 -2532 1788
BET1L -570 4145
BICD1 -849 2613
BICD2 3727 556
BIN1 -4095 617
BLOC1S1 4367 -817
BLOC1S3 205 6143
BLOC1S6 -789 4818
BNIP1 -2453 4079
C2CD5 -1285 6927
CALM1 -444 4502
CALR 2787 5714
CAPZA1 3644 999
CAPZA2 3025 4667
CAPZB 3664 -308
CBL 3838 1012
CCZ1 2013 -1870
CD3D -3572 7274
CD4 -2816 909
CD55 4431 1455
CD59 1454 -1684
CENPE 2054 -74
CHMP2A 4007 5362
CHMP2B 1081 1684
CHMP3 3197 3694
CHMP4A 1206 4138
CHMP4B 3974 5512
CHMP5 3912 4370
CHMP6 2834 2702
CHMP7 -3969 6064
CLINT1 1910 -1929
CLTA 2554 -546
CLTB 2902 -918
CLTC 4062 7259
CLTCL1 3483 4511
CNIH1 -999 6434
COG1 -2901 922
COG2 -2158 -1012
COG3 -800 755
COG4 3110 645
COG5 815 2084
COG6 -2694 3686
COG7 3891 3161
COG8 150 2377
COPA 4203 5455
COPB1 2918 2637
COPB2 3333 3476
COPE 3027 434
COPS2 325 6456
COPS3 450 1714
COPS4 -1011 5826
COPS5 1240 3236
COPS6 -443 782
COPS7A 3243 -66
COPS7B -1410 5099
COPS8 -3874 -1152
COPZ1 153 97
COPZ2 -2356 -1672
CPD 4315 -1840
CSNK1D 3147 3046
CTSC 3524 1311
CTSZ 3863 -1980
CUX1 4623 4795
CYTH1 -3959 6595
CYTH2 1059 2352
CYTH3 -1639 -968
CYTH4 4164 3823
DCTN2 4142 -727
DCTN3 2319 2751
DCTN4 4296 4417
DCTN5 109 6060
DCTN6 2715 6882
DENND1A 2598 3969
DENND1B -1185 7221
DENND1C 820 3359
DENND2C 2762 875
DENND2D -4197 7012
DENND3 4483 2137
DENND4A -925 2736
DENND4B 3344 1004
DENND5A 3781 1439
DENND6A 473 280
DNM1 2083 1607
DNM2 4115 3063
DTNBP1 -1267 284
DVL2 -2195 4884
DYNC1H1 590 4434
DYNC1I2 2356 693
DYNC1LI1 3051 3242
DYNC1LI2 2757 -185
DYNLL1 521 5151
DYNLL2 -1889 -924
EPN1 4307 5034
EPN2 1008 2946
EPS15 2107 -516
EPS15L1 3140 2728
EXOC1 3033 6223
EXOC2 -1752 5978
EXOC3 2627 3757
EXOC4 2245 1729
EXOC5 207 6716
EXOC6 4032 2017
EXOC7 3666 2374
EXOC8 2022 6708
FCHO1 -407 6034
FCHO2 2619 -593
FNBP1 1674 2510
FTH1 2431 3117
FTL 3951 -1426
GABARAP 2510 4039
GABARAPL2 2712 2948
GAK 3487 6665
GALNT2 4414 -1749
GAPVD1 3303 5351
GBF1 2773 4985
GCC1 1360 -1635
GCC2 -2613 3257
GDI2 2462 3343
GGA1 2524 4229
GGA2 -462 4335
GGA3 3155 671
GJD3 4243 -251
GNS 4663 4429
GOLGA1 3419 1794
GOLGA2 3585 -1361
GOLGA4 -1340 775
GOLGA5 2706 -549
GOLGB1 -1527 5355
GOLIM4 3427 2148
GORASP1 3693 -281
GOSR1 -1151 -852
GOSR2 2077 5880
GPS1 -882 6190
GRB2 4326 6241
HBEGF 729 -1007
HGS 3544 4351
HIP1 4202 6522
HIP1R -3753 -20
HPS1 3304 804
HPS4 -2687 4213
HSP90AA1 -1535 6210
HSP90B1 -644 2127
HSPH1 -3285 5508
HYOU1 1382 3849
IGF2R 4190 -1659
ITSN1 4329 3959
ITSN2 2288 -585
KDELR1 3680 4935
KDELR2 2213 1832
KIAA0319 2877 2703
KIF11 204 1895
KIF13B 3123 2528
KIF15 -567 6309
KIF16B -1779 5965
KIF18A -145 3290
KIF18B 2003 5532
KIF1B 4168 1220
KIF20A 1313 1403
KIF20B -3012 4534
KIF21A -2788 -346
KIF21B 1706 2388
KIF22 -4444 6183
KIF23 1467 805
KIF26B -3063 -1903
KIF27 1756 6076
KIF2A -2793 4006
KIF2C 710 -12
KIF3A -4208 6174
KIF3B 1849 2018
KIF3C 3567 -1430
KIF5B 3015 4670
KIF6 787 2531
KIF9 2389 2418
KIFAP3 -1460 -68
KIFC1 105 1767
KIFC2 -1170 2527
KLC1 3326 4386
KLC2 -2112 1505
KLC4 -1623 4367
LDLR 4270 1548
LDLRAP1 -4523 4896
LMAN1 -3700 5995
LMAN2 3619 6266
LMAN2L 544 1715
LNPEP -414 2406
M6PR -1871 5979
MADD 1104 -1304
MAN1A1 4388 1559
MAN1A2 -1587 3421
MAN1C1 -4490 145
MAN2A1 -1534 2421
MAN2A2 4046 2485
MCFD2 1763 2397
MIA3 -1397 4042
MON1A 252 1152
MON1B 4149 1931
MVB12A 2478 357
MYH9 3495 6146
MYO6 -1328 1793
NAA30 -3156 2646
NAA35 -2745 4714
NAA38 3120 -541
NAPA 2334 3102
NAPB 1116 2662
NAPG 2705 2684
NBAS 488 3732
NECAP1 2051 3774
NECAP2 -1427 3097
NEDD8 2724 -105
OPTN -3624 -509
PACSIN1 -4272 -1068
PACSIN2 4056 6931
PAFAH1B1 2858 6858
PAFAH1B2 2082 2435
PAFAH1B3 -1547 6671
PICALM 4026 -1233
PIP5K1C 2803 3895
PLA2G6 -2968 826
PLIN3 4647 23
POLG 377 3652
PPP6C 751 6979
PPP6R1 3468 -1034
PPP6R3 1282 -1719
PRKAB1 2545 -840
PRKAB2 -2142 3091
PRKAG1 2830 -1055
PRKAG2 -691 1021
PUM1 2628 6662
RAB10 4448 3067
RAB11A 2314 2440
RAB11B 1358 3899
RAB12 -783 -468
RAB14 1884 -378
RAB18 2497 2764
RAB1A 3881 6419
RAB1B 3928 4467
RAB27A 3688 222
RAB30 -3784 2925
RAB33B 1723 5180
RAB35 2709 905
RAB3A 2176 4348
RAB3GAP1 1775 3219
RAB3GAP2 2306 3837
RAB3IP -212 678
RAB43 2415 5468
RAB4A -608 559
RAB5A 2549 3958
RAB5B 3040 1957
RAB5C 3819 797
RAB6A 3874 3323
RAB7A 3957 -124
RAB8A 1901 1826
RAB8B 2800 1101
RABEP1 -1756 6121
RABEPK 2224 5565
RABGAP1 1995 6385
RABGEF1 2951 3772
RAC1 4263 5541
RACGAP1 2043 4089
RALA -2555 2302
RALGAPA2 4244 -284
RALGAPB 734 3710
REPS1 -51 6314
RGP1 2641 -1039
RHOBTB3 -1367 1297
RHOQ 993 -160
RIC1 2764 6857
RIN1 4563 -1288
RINL -527 6131
RINT1 -3942 3453
RPS27A -4373 2589
SAR1B 2437 3060
SBF1 -1192 3727
SCARB1 104 4837
SCARB2 3699 3550
SCOC -4016 2228
SEC13 2700 6211
SEC16A 3610 4812
SEC22A -3311 2581
SEC22C -1175 5700
SEC23A 2536 1833
SEC23IP 261 1231
SEC24A 3587 4762
SEC24B 2639 -13
SEC24C 3376 -336
SEC24D 4369 1527
SEC31A 1492 2523
SFN 639 -1779
SH3GL1 3692 6040
SNAP23 2713 -471
SNAP29 3459 3148
SNAPIN 2840 1354
SNF8 1860 5287
SNX18 4579 -690
SNX2 2248 186
SPTAN1 -4222 -407
SPTBN1 -3485 3657
SPTBN5 1628 2256
SRC -2558 -1476
STAM 314 6491
STAM2 2669 3301
STX10 4016 5277
STX16 1707 1974
STX17 -3415 -218
STX18 2216 2718
STX4 2492 1609
STX5 3177 5926
STX6 2795 -252
STXBP3 2569 199
SURF4 3061 3679
SYNJ1 4232 2804
SYNJ2 -4139 -505
SYS1 -744 4319
SYT11 2412 4051
SYTL1 -1787 -620
TBC1D1 3976 -1099
TBC1D10A -1440 5672
TBC1D10B 4145 6337
TBC1D10C -3207 6912
TBC1D13 3014 4704
TBC1D14 4533 30
TBC1D15 -1220 5333
TBC1D17 -1654 6199
TBC1D2 4365 647
TBC1D20 1352 1409
TBC1D24 1919 4060
TBC1D4 -4573 4593
TBC1D7 2498 5951
TFRC 1662 -131
TGFA 4463 4632
TGOLN2 4065 5919
TMED10 -1687 3393
TMED2 1834 5946
TMED3 1186 5786
TMED7 1363 -959
TMED9 2934 1623
TMEM115 2141 -632
TMF1 495 1642
TOR1A 3286 5481
TOR1B 3470 -606
TPD52 -3861 5618
TRAPPC1 3425 5233
TRAPPC10 906 6987
TRAPPC12 3763 7029
TRAPPC13 -174 7206
TRAPPC2L -665 1131
TRAPPC3 1526 -470
TRAPPC4 -923 1676
TRAPPC5 1136 29
TRAPPC6A -4264 -1706
TRAPPC6B 455 1818
TRAPPC8 2784 59
TRAPPC9 2284 -816
TRIP11 -1001 5856
TSC1 479 4696
TSC2 1480 3951
TSG101 2874 -488
TXNDC5 -784 -1873
UBA52 -1313 -69
UBAP1 4101 5038
UBB 355 5059
UBC 2129 3220
UBQLN1 1842 2747
ULK1 4556 1
USE1 -1971 654
USO1 849 3424
USP6NL 122 5625
VAMP2 -3788 -1239
VAMP3 3540 619
VAMP4 222 1517
VAMP8 -46 868
VPS25 3605 -962
VPS28 -269 6115
VPS36 -1723 1902
VPS37A 3267 3939
VPS37B 3202 -1611
VPS37C 4135 4035
VPS45 -141 3197
VPS4A 66 3112
VPS51 -3541 -1323
VPS52 1138 5049
VPS53 2209 4288
VPS54 1667 -1404
VTA1 1350 3950
VTI1A 3536 3539
WASL 1150 4645
YKT6 2749 3314
YWHAB 1621 2152
YWHAE 3368 1288
YWHAG 4167 1919
YWHAH 3924 -1276
YWHAQ -1781 3225
YWHAZ 1788 4294
ZW10 -230 -591



Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
metric value
setSize 76
pMANOVA 1.05e-20
p.adjustMANOVA 5.08e-19
s.dist 0.647
s.RNA -0.625
s.meth 0.167
p.RNA 4.83e-21
p.meth 0.012




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599
RPL37 -3340 5393
RPS7 -4048 4408

Click HERE to show all gene set members

All member genes
RNA meth
ASNS -3290 -387
ATF3 -1642 2814
ATF4 -19 765
CEBPB 4548 337
CEBPG 1441 1321
DDIT3 2252 5192
EIF2AK4 -601 2103
EIF2S1 -597 4745
EIF2S2 208 6254
FAU -1368 6877
GCN1 -2187 -1761
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
TRIB3 875 3767
UBA52 -1313 -69



Selenoamino acid metabolism

Selenoamino acid metabolism
metric value
setSize 76
pMANOVA 3.41e-20
p.adjustMANOVA 1.58e-18
s.dist 0.638
s.RNA -0.616
s.meth 0.166
p.RNA 1.57e-20
p.meth 0.0125




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599
RPL37 -3340 5393
RPS7 -4048 4408

Click HERE to show all gene set members

All member genes
RNA meth
AHCY -933 5996
AIMP2 -1261 5643
CTH -232 3809
EEF1E1 -1004 -948
EEFSEC -2608 1972
FAU -1368 6877
GSR 4497 4125
PAPSS1 4087 2272
PSTK -2230 -729
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
SCLY -3226 2139
SEPHS2 2957 1949
TXNRD1 3831 -1402
UBA52 -1313 -69



Influenza Infection

Influenza Infection
metric value
setSize 128
pMANOVA 8.2e-20
p.adjustMANOVA 3.66e-18
s.dist 0.493
s.RNA -0.448
s.meth 0.207
p.RNA 2.54e-18
p.meth 5.65e-05




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
NUP88 -4340 7084
RPL3 -4497 6753
RPS2 -4297 6975
NDC1 -4564 6482
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
NUP43 -3605 6346
NUP107 -3568 6301
IPO5 -4587 4875
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1256 1467
CALR 2787 5714
CANX 1159 3479
CLTA 2554 -546
CLTC 4062 7259
CPSF4 -1537 1770
DNAJC3 3801 6472
EIF2AK2 1924 683
FAU -1368 6877
GRSF1 -1089 4316
GTF2F1 2368 558
GTF2F2 2169 5307
HSP90AA1 -1535 6210
HSPA1A 3554 -920
IPO5 -4587 4875
ISG15 -1955 6541
KPNA1 -466 4423
KPNA2 -944 4421
KPNA3 -719 4400
KPNA4 1962 5000
KPNA5 -3957 1847
KPNB1 1929 1140
NDC1 -4564 6482
NUP107 -3568 6301
NUP133 -2062 935
NUP153 96 4344
NUP155 -2910 3043
NUP160 -3599 1293
NUP188 -3388 2922
NUP205 -3151 1670
NUP210 -1503 690
NUP214 3964 4369
NUP35 -4376 -557
NUP37 -837 3398
NUP43 -3605 6346
NUP50 935 6706
NUP54 -2949 831
NUP62 -899 4609
NUP85 -1286 4518
NUP88 -4340 7084
NUP93 -2587 2006
NUP98 2030 -747
PABPN1 -645 3061
PARP1 -3618 3582
POLR2A 2854 4046
POLR2B -1272 5563
POLR2C -184 6356
POLR2D -2801 -614
POLR2E 1754 3712
POLR2F 1457 509
POLR2G 1427 1604
POLR2H -2461 6299
POLR2I -1497 5657
POLR2K -1891 3853
POM121 -48 4681
POM121C -623 2061
RAE1 1714 2634
RAN -3671 1483
RANBP2 -405 5165
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
SEC13 2700 6211
SEH1L -4285 3577
TGFB1 1897 3769
TPR -1423 4616
UBA52 -1313 -69
XPO1 -1207 6847



SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
metric value
setSize 85
pMANOVA 6.57e-19
p.adjustMANOVA 2.83e-17
s.dist 0.587
s.RNA -0.55
s.meth 0.205
p.RNA 1.92e-18
p.meth 0.00113




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
SRPRB -3153 6605
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599
RPL37 -3340 5393

Click HERE to show all gene set members

All member genes
RNA meth
FAU -1368 6877
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPN1 2547 6053
RPN2 3320 5501
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
SEC11A 2324 5768
SEC11C -2384 4501
SEC61A1 2689 421
SEC61A2 -2056 301
SEC61B 1487 6424
SEC61G -1179 1928
SPCS2 -353 6694
SPCS3 689 1497
SRP14 1720 5764
SRP19 -229 5846
SRP54 2878 4032
SRP68 277 4340
SRP72 -1341 307
SRPRB -3153 6605
SSR1 393 3856
SSR2 -1085 -133
SSR3 883 -75
TRAM1 -2599 906
UBA52 -1313 -69



Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
metric value
setSize 86
pMANOVA 1.64e-18
p.adjustMANOVA 6.56e-17
s.dist 0.578
s.RNA -0.537
s.meth 0.215
p.RNA 8.41e-18
p.meth 0.00058




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
UPF3A -3854 6963
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
NCBP2 -4320 4777
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599

Click HERE to show all gene set members

All member genes
RNA meth
CASC3 3679 5106
DCP1A -1860 5069
EIF4A3 509 4598
EIF4G1 4196 5766
ETF1 2407 151
FAU -1368 6877
GSPT1 -741 -1155
NCBP1 -340 5859
NCBP2 -4320 4777
PABPC1 -1115 3011
PNRC2 -1416 5678
PPP2CA 2390 2598
PPP2R2A 619 -752
RNPS1 -3428 537
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
SMG1 -180 4789
SMG5 1671 5173
SMG6 -173 6207
SMG7 4117 2361
SMG8 1710 1691
UBA52 -1313 -69
UPF1 3435 5958
UPF2 443 3840
UPF3A -3854 6963



Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
metric value
setSize 86
pMANOVA 1.64e-18
p.adjustMANOVA 6.56e-17
s.dist 0.578
s.RNA -0.537
s.meth 0.215
p.RNA 8.41e-18
p.meth 0.00058




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
UPF3A -3854 6963
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
NCBP2 -4320 4777
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599

Click HERE to show all gene set members

All member genes
RNA meth
CASC3 3679 5106
DCP1A -1860 5069
EIF4A3 509 4598
EIF4G1 4196 5766
ETF1 2407 151
FAU -1368 6877
GSPT1 -741 -1155
NCBP1 -340 5859
NCBP2 -4320 4777
PABPC1 -1115 3011
PNRC2 -1416 5678
PPP2CA 2390 2598
PPP2R2A 619 -752
RNPS1 -3428 537
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
SMG1 -180 4789
SMG5 1671 5173
SMG6 -173 6207
SMG7 4117 2361
SMG8 1710 1691
UBA52 -1313 -69
UPF1 3435 5958
UPF2 443 3840
UPF3A -3854 6963



Signaling by Receptor Tyrosine Kinases

Signaling by Receptor Tyrosine Kinases
metric value
setSize 284
pMANOVA 1.18e-14
p.adjustMANOVA 4.56e-13
s.dist 0.275
s.RNA 0.273
s.meth 0.0329
p.RNA 3.75e-15
p.meth 0.344




Top 20 genes
Gene RNA meth
FURIN 4424 7181
ATP6V0D1 4480 6936
CLTC 4062 7259
PTPRJ 4090 7170
PRKCD 4562 6360
MAPK1 4578 6099
PTPN6 4161 6542
CRK 4125 6598
SHB 4083 6644
RALB 3954 6833
GRB2 4326 6241
ATP6V1C1 3836 6759
APH1B 3616 6785
ELMO2 3996 6110
RAC1 4263 5541
VAV1 4015 5834
SPRED2 4192 5462
SH3GL1 3692 6040
IRS2 3595 6152
EPN1 4307 5034

Click HERE to show all gene set members

All member genes
RNA meth
AAMP -2521 7121
ABI1 3566 3253
ABI2 -3506 -206
ADAM10 3893 2760
ADAM17 4453 4155
ADAP1 3944 -1541
ADORA2A 1463 7186
AHCYL1 2529 2692
AKT1 2261 1109
AKT2 1896 5431
AP2A1 4643 -316
AP2M1 3281 3723
AP2S1 2943 6039
APH1A 904 -119
APH1B 3616 6785
ARF6 1056 3741
ARHGEF7 -172 330
ATF1 901 2989
ATP6V0A1 4614 -1571
ATP6V0A2 -2659 6653
ATP6V0B 3770 5503
ATP6V0C 4469 2933
ATP6V0D1 4480 6936
ATP6V0E1 3116 1836
ATP6V0E2 -4219 -1327
ATP6V1A 3646 -1497
ATP6V1B2 3599 -1555
ATP6V1C1 3836 6759
ATP6V1D 3887 1096
ATP6V1E1 3016 4776
ATP6V1F 1310 -699
ATP6V1G2 -4032 3740
ATP6V1H 2526 2559
BAIAP2 -676 2757
BAX 1873 1161
BRAF 1497 -1526
BRK1 -951 3071
CALM1 -444 4502
CAV1 779 4592
CBL 3838 1012
CDC42 3077 856
CDK5 4265 3491
CDK5R1 469 7124
CHD4 107 640
CHEK1 -2434 51
CLTA 2554 -546
CLTC 4062 7259
COL9A2 601 4444
CREB1 -1515 1422
CRK 4125 6598
CRKL 1801 5167
CSK 3579 4890
CTNNB1 3708 5070
CTNND1 868 -1709
CUL5 -1067 344
CYBA 3986 2019
CYFIP1 4146 256
CYFIP2 -275 6159
DIAPH1 2535 2371
DLG4 3788 2607
DNAL4 -273 2609
DNM1 2083 1607
DNM2 4115 3063
DOCK7 -1565 2327
DUSP3 3162 2260
DUSP4 -775 2494
DUSP6 -1141 -1943
DUSP7 -914 722
EGR1 -1531 1893
EGR2 -2670 4748
ELMO1 1879 939
ELMO2 3996 6110
EP300 3773 4901
EPN1 4307 5034
EPS15 2107 -516
EPS15L1 3140 2728
ERBB2 -2433 4160
ESRP2 360 -276
FER -250 2567
FES 4457 -1638
FGF9 -3672 997
FGFBP3 -1105 207
FGFRL1 -278 5867
FLT3LG -4565 6677
FOS 989 5647
FOSB -810 1975
FOSL1 2848 6224
FRS2 -406 -882
FRS3 2782 6525
FURIN 4424 7181
FYN -2007 2793
GAB2 4209 2390
GALNT3 3280 -712
GGA3 3155 671
GRAP2 -764 3631
GRB10 4673 3328
GRB2 4326 6241
GTF2F1 2368 558
GTF2F2 2169 5307
HBEGF 729 -1007
HGS 3544 4351
HNRNPF 452 5857
HNRNPH1 -3044 2373
HNRNPM 1556 2773
HRAS -2033 -823
HSP90AA1 -1535 6210
HSPB1 -556 883
ID1 2998 5399
ID2 3611 1192
ID3 -1581 -55
IGF1R 2444 -1422
INSR 3577 3558
IRS1 -2377 4308
IRS2 3595 6152
ITCH 2375 4854
ITGA2 -1406 -260
ITGAV 2851 -370
ITPR1 -1390 1789
ITPR2 2788 -44
ITPR3 -2430 2189
JAK2 1521 6489
JUNB 2595 5018
JUND -840 4243
KIDINS220 3553 3650
KRAS 2127 3139
LAMA2 -1282 6004
LAMB2 -17 1884
LCK -4275 7246
LRIG1 -4518 -692
LYL1 3875 -1349
MAP2K1 3972 1533
MAP2K2 2576 6410
MAP2K5 788 3448
MAPK1 4578 6099
MAPK14 4535 2465
MAPK3 3753 1978
MAPK7 3913 -244
MAPKAP1 1572 5908
MAPKAPK2 3308 3265
MAPKAPK3 4600 2896
MEF2A 3832 3013
MEF2D 2521 177
MEMO1 2679 1334
MKNK1 4078 1392
MLST8 -375 2258
MST1 2015 1923
MST1R -1239 -1885
MTOR 616 3900
MXD4 -1411 6707
NAB1 813 5391
NAB2 -1510 3891
NCBP1 -340 5859
NCBP2 -4320 4777
NCF4 4375 -1941
NCK1 -3937 1018
NCK2 -1079 1378
NCKAP1L 4625 -320
NCOR1 2997 -530
NCSTN 4682 1224
NEDD4 3710 -1106
NELFB 627 -649
NOS3 -2969 4048
NTRK1 -1442 7049
PAG1 2103 6279
PAK1 3920 2452
PAK2 3401 283
PCSK5 2119 -869
PDE3B -4043 3507
PDPK1 3242 346
PGF 485 -1150
PIK3CA 749 1470
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R3 943 3645
PIK3R4 -767 2170
PLCG1 -4193 958
POLR2A 2854 4046
POLR2B -1272 5563
POLR2C -184 6356
POLR2D -2801 -614
POLR2E 1754 3712
POLR2F 1457 509
POLR2G 1427 1604
POLR2H -2461 6299
POLR2I -1497 5657
POLR2K -1891 3853
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5D 2308 3470
PRKACA 4651 890
PRKACB -4452 1712
PRKCA -898 6894
PRKCB 3189 4964
PRKCD 4562 6360
PRKCE 3011 -1185
PRKCZ -2369 -1376
PRR5 -2760 -347
PSEN1 4153 4955
PSEN2 -2556 -162
PSENEN 2520 4980
PTBP1 -1053 815
PTK2 147 -475
PTK2B 4572 4529
PTPN1 4262 699
PTPN11 2272 5062
PTPN12 2791 -982
PTPN18 4432 3436
PTPN2 3465 181
PTPN6 4161 6542
PTPRJ 4090 7170
PTPRU 2683 -1728
PXN 3967 -814
RAB4A -608 559
RAB4B 3134 4688
RAC1 4263 5541
RALA -2555 2302
RALB 3954 6833
RALGDS -3104 6406
RANBP10 1673 5496
RANBP9 2458 884
RAP1A 2631 6569
RAP1B 2468 5968
RAPGEF1 1750 6445
RASA1 2167 3434
REST 517 1286
RHOA 3580 4033
RICTOR -2029 2833
RIT1 4306 2694
RNF41 4047 4402
ROCK1 3235 2732
RPS27A -4373 2589
RPS6KA1 4529 -1859
RPS6KA2 1506 2117
RPS6KA5 -4174 1991
SGK1 -2490 -1194
SH2B3 2353 3851
SH2D2A -2483 6509
SH3GL1 3692 6040
SHB 4083 6644
SHC1 3650 3205
SOCS1 1609 4130
SOS1 -1111 -1986
SPRED1 1227 6065
SPRED2 4192 5462
SPRY1 -451 2310
SPRY2 1327 1690
SRC -2558 -1476
SRF 3509 2816
STAM 314 6491
STAM2 2669 3301
STAT1 -4215 4970
STAT3 3745 4995
STAT5A 2844 -1545
STAT5B 3260 1495
STAT6 3810 3854
STMN1 -3244 3009
STUB1 -996 2320
TAB2 693 6401
TCF12 833 -542
TCIRG1 4550 1353
TEC 3772 170
TGFA 4463 4632
THBS3 2900 -662
THEM4 -4578 809
TIA1 -1428 2854
TIAL1 -1725 5521
TLR9 -10 7204
TRIB3 875 3767
UBA52 -1313 -69
UBB 355 5059
UBC 2129 3220
USP8 2559 4109
VAV1 4015 5834
VAV2 975 4134
VAV3 3114 -685
VEGFA 1946 87
VRK3 2567 2903
WASF1 4637 -830
WASF2 4371 -134
WWOX -3993 4712
WWP1 -4510 479
YES1 -1057 5198
YWHAB 1621 2152



Metabolism of lipids

Metabolism of lipids
metric value
setSize 427
pMANOVA 3.45e-12
p.adjustMANOVA 1.29e-10
s.dist 0.21
s.RNA 0.206
s.meth -0.0372
p.RNA 5.07e-13
p.meth 0.194




Top 20 genes
Gene RNA meth
GGT1 4684 -1937
TBXAS1 4570 -1853
ARF1 4256 -1821
NCOR2 4583 -1609
CHPT1 3796 -1714
SQLE 4058 -1595
AGPAT2 4500 -1388
PGS1 4451 -1358
ARSB 3918 -1528
ALOX5AP 3816 -1566
TXNRD1 3831 -1402
GPD2 3432 -1558
DHCR24 4049 -1295
SAMD8 2929 -1768
CHKA 3581 -1259
HACD1 3072 -1445
GLTP 4155 -1009
PLD1 4524 -902
DGAT2 4565 -892
PISD 4426 -888

Click HERE to show all gene set members

All member genes
RNA meth
AACS 178 5129
ABCA1 2264 -82
ABCC1 1856 -26
ABHD3 3434 2912
ABHD4 2945 574
ABHD5 3861 1319
ACAA1 4515 5790
ACACA 3683 1077
ACACB -2244 -519
ACAD10 3298 2091
ACAD11 -2171 5734
ACADM -3046 -637
ACADS 1809 -1452
ACAT1 -658 4902
ACAT2 -2817 777
ACBD4 -1904 1001
ACBD5 1825 2753
ACBD6 -1905 372
ACBD7 1411 4804
ACER2 -985 315
ACER3 4100 6816
ACLY 4042 2976
ACOT13 3050 2379
ACOT7 -1843 6020
ACOT8 4382 5475
ACOX1 4048 4104
ACOX3 4105 5381
ACOXL 2603 7260
ACP6 -1607 5126
ACSF2 -569 3532
ACSF3 1133 4103
ACSL1 4528 6607
ACSL3 3332 -732
ACSL5 -1100 2404
ACSL6 -4421 7278
ACSM3 -3653 698
AGK -3770 492
AGPAT1 2681 5849
AGPAT2 4500 -1388
AGPAT3 2889 637
AGPAT4 2716 -315
AGPAT5 -4152 5438
AGPS 1114 -195
AHR 397 5027
AHRR -480 6738
AKR1B1 -4462 4190
ALDH3A2 -526 5655
ALOX5 4569 5386
ALOX5AP 3816 -1566
AMACR -205 6130
ARF1 4256 -1821
ARF3 3612 274
ARNT 4019 4409
ARNTL 2439 1097
ARSA 3137 523
ARSB 3918 -1528
ARSG 94 4004
ARSK -4526 4078
ARV1 1145 6971
ASAH1 4363 2174
BDH1 -4312 796
BDH2 -3392 -1583
CAV1 779 4592
CBR4 -23 2046
CCNC -2845 4188
CDIPT 1760 2141
CDK19 3739 975
CDK8 1491 5795
CDS2 2857 540
CEPT1 14 169
CERK -2396 -203
CERS5 1232 -1210
CERS6 1648 -762
CHD9 42 -1054
CHKA 3581 -1259
CHKB 142 6851
CHPT1 3796 -1714
CLOCK -1962 3525
CPNE1 -590 5132
CPNE3 1048 -1443
CPT1A 1797 -1598
CPT2 4438 -446
CPTP 1348 5330
CRAT 3201 2473
CREBBP 2992 892
CRLS1 2563 6323
CSNK1G2 1349 2563
CSNK2A2 2634 5736
CSNK2B 2032 4743
CTSA 4396 2720
CYP2R1 -942 3262
CYP2U1 -3212 3858
CYP46A1 -216 3979
CYP4F22 1624 5603
CYP51A1 3538 -89
DBI 2979 1598
DDHD1 -3234 4148
DDHD2 -4221 687
DECR1 2474 3217
DECR2 -655 3974
DEGS1 1101 3203
DGAT1 1776 -576
DGAT2 4565 -892
DHCR24 4049 -1295
DHCR7 3412 4809
DHRS7B 3886 345
DPEP2 776 -1338
ECHS1 -2783 3252
ECI1 -1178 -1283
ECI2 -4347 296
EHHADH 3366 2918
ELOVL1 3806 6602
ELOVL4 -4539 3377
ELOVL5 1953 2656
ELOVL6 -997 521
EP300 3773 4901
EPHX2 -4563 -695
ESRRA 3477 5421
ESYT1 -4324 4321
ESYT2 -4096 1696
ETNK1 -422 5868
FABP5 2875 2233
FADS1 4406 3002
FADS2 2573 -779
FAM120B 3572 -222
FAR1 3570 313
FASN -642 4278
FDFT1 3596 3920
FDPS 2184 4338
FDX1 -1596 3052
FDXR 881 1657
FIG4 4188 6859
FITM2 -3105 910
GALC 4532 4245
GBA 4633 45
GBA2 3542 -583
GDE1 3207 5340
GDPD1 -251 3142
GDPD5 -2332 235
GGPS1 -2295 541
GGT1 4684 -1937
GLB1 4012 1828
GLIPR1 1606 5593
GLTP 4155 -1009
GM2A 4398 6363
GPAM -3583 81
GPCPD1 3769 7103
GPD1 -946 -633
GPD1L -3304 -403
GPD2 3432 -1558
GPS2 896 6830
GPX1 2467 -875
GPX4 1371 4419
GSTM4 1696 2362
HACD1 3072 -1445
HACD2 -2495 6437
HACD3 -4313 3440
HACD4 1470 6326
HACL1 -4286 3807
HADH -4060 -364
HADHA 1618 2805
HADHB 3956 3179
HDAC3 1870 7116
HEXA -721 5238
HEXB 2779 2906
HILPDA -191 1618
HMGCL 3794 6683
HMGCR 3440 4522
HMGCS1 489 3457
HPGD 3622 6954
HSD17B1 226 2592
HSD17B11 1560 5772
HSD17B12 1485 5884
HSD17B4 3349 2004
HSD17B8 -3091 5823
IDI1 3501 2766
INPP4A 1604 5041
INPP5D 3395 55
INPP5E -3002 496
INPP5F 786 3598
INPP5K 732 2453
INPPL1 4354 588
INSIG1 1977 3015
INSIG2 2354 -1219
KPNB1 1929 1140
LBR 3297 2128
LCLAT1 -493 4863
LGMN -3257 2706
LIPE -3482 5509
LPCAT1 2780 1418
LPCAT3 4386 1514
LPCAT4 -2208 2192
LPGAT1 3686 -464
LPIN1 -2427 2315
LPIN2 -2026 6919
LSS -2046 -719
LTA4H 4219 798
LTC4S -228 -1874
MAPKAPK2 3308 3265
MBOAT1 2400 500
MBOAT7 4332 4179
MBTPS1 2259 2401
MCAT -6 4956
MCEE -858 1366
MECR -1396 6054
MED1 -348 4473
MED10 -3710 2697
MED11 1117 5168
MED13 230 6580
MED13L 3603 5940
MED15 -325 5803
MED16 1422 -884
MED17 -983 3538
MED18 3184 -268
MED19 -656 2674
MED20 3265 180
MED21 -1138 4075
MED22 946 -1308
MED23 665 3755
MED24 410 5183
MED25 2987 565
MED26 2277 3021
MED27 -1109 1874
MED28 176 219
MED29 -1408 -373
MED30 -1056 4136
MED31 -935 2499
MED4 -831 127
MED6 -2728 6745
MED7 409 4941
MED8 3216 1234
MED9 -541 1721
MFSD2A -2699 -1143
MLYCD 458 3456
MMAA -2789 6866
MORC2 -3603 7284
MSMO1 1578 5195
MTF1 4267 5712
MTMR10 3534 6805
MTMR12 1351 4654
MTMR14 3076 3137
MTMR2 -1214 1909
MTMR3 4561 613
MTMR4 2768 3784
MTMR6 2933 2060
MTMR9 1635 4286
MVD 1063 190
MVK 1049 3791
NCOA2 2872 2432
NCOA3 3005 3815
NCOA6 4079 419
NCOR1 2997 -530
NCOR2 4583 -1609
NDUFAB1 -1778 4045
NEU1 4519 1899
NEU3 -192 -1014
NFYA 2338 102
NFYB -4555 1588
NFYC 4173 226
NR1D1 -4064 5907
NR1H2 3638 6463
NR1H3 330 6206
NRF1 -37 -1257
NUDT19 2853 6786
NUDT7 910 3989
ORMDL1 -1487 5782
ORMDL3 -2451 3085
OSBP 562 370
OSBPL2 3623 2403
OSBPL3 -3732 1202
OSBPL5 -298 -1848
OSBPL7 -3065 -1677
OSBPL8 2255 4416
OSBPL9 2809 3235
OXCT1 -4309 3313
PCCB -2147 -1153
PCTP 3502 6638
PCYT1A 3607 5272
PCYT2 -2246 -368
PECR 3615 6201
PEMT -1128 5572
PEX11A 220 3970
PGS1 4451 -1358
PHOSPHO1 3433 5611
PI4K2A 2534 5682
PI4K2B -4278 2370
PI4KA 1709 2317
PI4KB 1164 5395
PIAS4 3355 1744
PIK3CA 749 1470
PIK3CD 3357 6109
PIK3CG 3446 2051
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R3 943 3645
PIK3R4 -767 2170
PIK3R5 2731 4483
PIKFYVE 1625 -725
PIP4K2A 144 3045
PIP4K2B -2458 1071
PIP4K2C 386 223
PIP5K1A 2157 4436
PIP5K1C 2803 3895
PISD 4426 -888
PITPNB -1910 4752
PITPNM1 4346 3850
PITPNM2 -281 7241
PITPNM3 -211 6590
PLA2G12A -1377 767
PLA2G15 4559 3624
PLA2G4C -2202 3866
PLA2G6 -2968 826
PLB1 4683 -114
PLD1 4524 -902
PLD3 2198 354
PLD6 -4381 5490
PLEKHA2 959 -1137
PLEKHA3 -710 -1381
PLEKHA6 1243 -1434
PLEKHA8 -1002 -788
PLIN2 3793 1747
PLIN3 4647 23
PMVK 1323 3437
PNPLA2 4070 281
PNPLA6 4275 2173
PNPLA7 -1682 1447
PNPLA8 2295 -143
PON2 -2429 -1456
PPARD -3366 -791
PPARGC1B -8 1449
PPM1L 1638 6865
PPP1CA 2035 4238
PPP1CB 2372 -340
PPP1CC 196 5379
PPT1 4080 1132
PPT2 -2594 -1409
PRKAB2 -2142 3091
PRKACA 4651 890
PRKACB -4452 1712
PRKAG2 -691 1021
PRKD2 712 5530
PSAP 3330 628
PTDSS2 1046 2429
PTEN 3653 4815
PTGES2 -2116 -901
PTGES3 -1846 4287
PTGR1 4402 183
PTGR2 60 -1417
PTPMT1 194 -467
PTPN13 -2382 6850
RAB14 1884 -378
RAB4A -608 559
RAB5A 2549 3958
RAN -3671 1483
RGL1 4337 3381
RORA -4061 6933
RUFY1 1288 317
SACM1L -1995 2312
SAMD8 2929 -1768
SAR1B 2437 3060
SBF1 -1192 3727
SC5D 165 -891
SCAP -816 -731
SCD 2394 -1082
SCP2 -726 6351
SEC23A 2536 1833
SEC24A 3587 4762
SEC24B 2639 -13
SEC24C 3376 -336
SEC24D 4369 1527
SGMS1 3575 4256
SGPL1 3746 -1015
SGPP1 -1066 -665
SIN3A -3277 3819
SIN3B 731 -419
SLC22A5 2608 5708
SLC25A1 2398 4558
SLC25A17 -4023 -379
SLC25A20 3456 4787
SLC27A1 2058 1124
SLC27A2 -2500 -1411
SLC27A3 887 7018
SLC27A5 337 -1574
SLC44A1 2257 924
SLC44A2 1778 4323
SMPD1 2223 6502
SMPD2 1410 6784
SMPD3 -2725 7226
SP1 3722 4865
SPHK2 2506 670
SPTLC1 3555 3337
SPTLC2 3656 1289
SPTLC3 -55 -1650
SPTSSA -1176 -193
SQLE 4058 -1595
SRD5A1 3199 6932
SRD5A3 2451 2696
SREBF1 798 2475
SREBF2 3808 4296
STARD10 49 3166
STARD3 2891 3852
STARD3NL 2638 2506
STARD4 1496 -100
STARD5 2823 1237
STARD7 784 5188
SUMF1 3959 -728
SUMF2 -3432 38
SYNJ1 4232 2804
SYNJ2 -4139 -505
TBL1XR1 1666 2633
TBXAS1 4570 -1853
TECR -3569 5770
THEM4 -4578 809
TIAM2 1135 -1147
TM7SF2 -2936 1399
TNFAIP8 -4104 4923
TNFAIP8L1 -3721 1829
TNFAIP8L2 1271 -165
TRIB3 875 3767
TSPO 4279 6747
TXNRD1 3831 -1402
UBE2I -873 5796
UGCG 2686 3873
VAC14 2313 2508
VAPA 3695 4246
VAPB -204 -1989
VDR 4654 3980



Hemostasis

Hemostasis
metric value
setSize 303
pMANOVA 9.59e-12
p.adjustMANOVA 3.48e-10
s.dist 0.24
s.RNA 0.24
s.meth -0.0123
p.RNA 1.07e-12
p.meth 0.715




Top 20 genes
Gene RNA meth
P2RX1 4678 -1949
GNA15 4425 -1924
NFE2 4620 -1804
SLC16A3 4605 -1654
TOR4A 4473 -1620
GNAQ 3823 -1832
ATP2A2 4104 -1550
EHD2 2955 -1841
PDE1B 4095 -1314
SELPLG 3316 -1614
KIF3C 3567 -1430
FGR 4634 -1075
SERPINE2 2514 -1730
APLP2 4439 -964
MICAL1 4495 -904
TGFB2 2115 -1899
GYPC 2290 -1743
TLN1 3997 -983
AKAP10 3347 -1112
PLAUR 4189 -861

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -532 567
AAMP -2521 7121
ABCC4 569 2355
ABHD12 -1857 5950
ABHD6 2336 2533
ABL1 2124 2469
ACTN1 3787 7240
ACTN4 4018 1596
AK3 -1201 485
AKAP1 -4455 5977
AKAP10 3347 -1112
AKT1 2261 1109
ALDOA 4405 5367
ANXA5 3519 2872
APBB1IP 4261 3821
APLP2 4439 -964
APP 2164 6623
ARRB1 1355 -1278
ARRB2 4301 2913
ATP1B1 -2422 6453
ATP1B3 2185 4129
ATP2A1 1366 5724
ATP2A2 4104 -1550
ATP2A3 1257 1877
ATP2B4 2835 4069
BRPF3 432 3308
BSG 3910 205
C1QBP -4004 5787
CABLES2 -231 -697
CALM1 -444 4502
CALU 3405 1962
CAP1 3857 2034
CAPZA1 3644 999
CAPZA2 3025 4667
CAPZB 3664 -308
CAV1 779 4592
CD2 -4015 7277
CD244 -1147 3968
CD44 3510 4898
CD47 -4047 6603
CD48 -260 6883
CD58 3716 -611
CD63 4648 5434
CD74 -3590 -648
CD84 2527 304
CDC37L1 -2940 519
CDC42 3077 856
CDK2 -1366 2965
CDK5 4265 3491
CEACAM1 3407 5459
CENPE 2054 -74
CFL1 3776 1646
CHID1 276 1830
CRK 4125 6598
CSK 3579 4890
CYB5R1 4498 5881
DAGLB 4088 -302
DGKA -3866 7033
DGKD 2424 4806
DGKE -3765 6507
DGKG 3030 4393
DGKH -872 4127
DGKQ -377 3114
DGKZ -854 -1315
DOCK10 -3843 -1158
DOCK4 4317 4094
DOCK7 -1565 2327
DOCK8 3682 900
DOCK9 -4424 5506
DOK2 1309 1156
EHD1 2893 904
EHD2 2955 -1841
EHD3 357 -335
ENDOD1 -530 -639
F11R 1293 -1146
F12 4667 1484
FAM3C -4101 32
FERMT3 4471 5112
FGR 4634 -1075
FYN -2007 2793
GATA3 -4560 6274
GLG1 1488 1825
GNA12 -295 4303
GNA13 1819 3330
GNA15 4425 -1924
GNAI2 4039 3218
GNAI3 3078 2359
GNAQ 3823 -1832
GNAS 2061 -60
GNB1 4127 2799
GNB2 4050 1879
GNB4 2511 1335
GNB5 -1874 6256
GNG2 1099 6500
GNG3 1539 7142
GNG4 870 6856
GNG5 4320 6512
GNG7 -2307 -499
GNGT2 511 7120
GRB2 4326 6241
GTPBP2 4571 4515
GYPC 2290 -1743
HABP4 -4540 3365
HDAC1 239 3287
HDAC2 -2809 5864
HMG20B 835 1259
HRAS -2033 -823
INPP5D 3395 55
IRF1 -2321 5832
IRF2 3058 2365
ITGA1 3636 2777
ITGA2 -1406 -260
ITGA4 -3219 -394
ITGA5 3809 3467
ITGA6 -4258 5920
ITGAL 1255 7038
ITGAV 2851 -370
ITGB2 4401 6426
ITPK1 4076 4524
ITPR1 -1390 1789
ITPR2 2788 -44
ITPR3 -2430 2189
JAK2 1521 6489
JAM2 -138 5426
JMJD1C -137 2975
KCNMB4 -483 712
KDM1A -3041 5493
KIF11 204 1895
KIF13B 3123 2528
KIF15 -567 6309
KIF16B -1779 5965
KIF18A -145 3290
KIF18B 2003 5532
KIF1B 4168 1220
KIF20A 1313 1403
KIF20B -3012 4534
KIF21A -2788 -346
KIF21B 1706 2388
KIF22 -4444 6183
KIF23 1467 805
KIF26B -3063 -1903
KIF27 1756 6076
KIF2A -2793 4006
KIF2C 710 -12
KIF3A -4208 6174
KIF3B 1849 2018
KIF3C 3567 -1430
KIF5B 3015 4670
KIF6 787 2531
KIF9 2389 2418
KIFAP3 -1460 -68
KIFC1 105 1767
KIFC2 -1170 2527
KLC1 3326 4386
KLC2 -2112 1505
KLC4 -1623 4367
KRAS 2127 3139
LCK -4275 7246
LCP2 1292 -428
LRP8 3700 4757
MAFF 681 6749
MAFG 4220 4552
MAFK 1646 -1176
MANF 167 6556
MAPK1 4578 6099
MAPK14 4535 2465
MAPK3 3753 1978
MFN1 -1153 1048
MFN2 3109 -1030
MICAL1 4495 -904
MIF -2932 3355
MYB -1717 -449
NFE2 4620 -1804
NHLRC2 -1815 -59
NOS3 -2969 4048
OLA1 -2243 6473
ORAI1 -2266 2153
ORAI2 3079 -132
P2RX1 4678 -1949
P2RX4 2871 398
P2RX5 -3515 1377
P2RY1 4657 3720
PAFAH2 -2013 3736
PCYOX1L -161 2972
PDE1B 4095 -1314
PDE2A 966 -1910
PDE5A 584 3824
PDE9A -3677 -1809
PDPK1 3242 346
PFN1 3107 3814
PHACTR2 1287 -1839
PHF21A 4672 5215
PICK1 2367 1314
PIK3CA 749 1470
PIK3CG 3446 2051
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R3 943 3645
PIK3R5 2731 4483
PLAU 1336 -1529
PLAUR 4189 -861
PLCG1 -4193 958
PLCG2 4027 2803
PLEK 1612 -567
PPIA -2610 4555
PPIL2 -509 -350
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5A 3798 -230
PPP2R5B 3843 -286
PPP2R5C -2002 7074
PPP2R5D 2308 3470
PPP2R5E -960 1402
PRCP 3166 611
PRKACA 4651 890
PRKACB -4452 1712
PRKAR1A 4198 -432
PRKAR1B 1950 1230
PRKAR2A 2666 -874
PRKCA -898 6894
PRKCB 3189 4964
PRKCD 4562 6360
PRKCE 3011 -1185
PRKCH -4304 2578
PRKCQ -4200 4208
PRKCZ -2369 -1376
PRTN3 -4157 5621
PSAP 3330 628
PTK2 147 -475
PTPN1 4262 699
PTPN11 2272 5062
PTPN6 4161 6542
QSOX1 4653 5727
RAB5A 2549 3958
RAC1 4263 5541
RAC2 3032 4577
RACGAP1 2043 4089
RAD51B 3754 6320
RAF1 3715 6573
RAP1A 2631 6569
RAP1B 2468 5968
RASGRP1 -4180 5888
RASGRP2 -2424 -413
RBSN 404 6354
RCOR1 4251 -178
RHOA 3580 4033
RHOB 2885 2346
RHOG 4271 3664
S100A10 1824 5902
SCCPDH 4059 1126
SDC4 1974 2364
SELPLG 3316 -1614
SERPINB6 1810 2823
SERPINB8 3498 -793
SERPINE2 2514 -1730
SH2B1 -2131 1436
SH2B3 2353 3851
SHC1 3650 3205
SIN3A -3277 3819
SLC16A1 -540 5451
SLC16A3 4605 -1654
SLC3A2 2487 744
SLC7A11 -713 -895
SLC7A5 1740 -1904
SLC7A6 -3434 6043
SLC8A3 -1764 -118
SOD1 -3096 1838
SOS1 -1111 -1986
SPN -2713 -1782
SRC -2558 -1476
SRGN 3830 1395
SRI 2837 -271
STIM1 3982 7265
STX4 2492 1609
STXBP2 4615 -155
STXBP3 2569 199
SYK 4033 431
TAGLN2 889 1679
TEX264 -1536 5266
TGFB1 1897 3769
TGFB2 2115 -1899
TGFB3 -2827 -978
TLN1 3997 -983
TMX3 -1365 -543
TNFRSF10A -1036 2821
TNFRSF10B 3351 -670
TNFRSF10D 2443 3086
TOR4A 4473 -1620
TP53 -4050 2709
TUBA4A 2938 4105
VAV1 4015 5834
VAV2 975 4134
VAV3 3114 -685
VCL 2144 3614
VEGFA 1946 87
VPS45 -141 3197
VTI1B 3343 3178
WDR1 3821 7036
WEE1 -1403 5101
YES1 -1057 5198
YWHAZ 1788 4294
ZFPM1 -1716 6831



Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs
metric value
setSize 122
pMANOVA 1.75e-11
p.adjustMANOVA 6.17e-10
s.dist 0.381
s.RNA -0.327
s.meth 0.195
p.RNA 4.74e-10
p.meth 0.000203




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
UPF3A -3854 6963
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
NCBP2 -4320 4777
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599

Click HERE to show all gene set members

All member genes
RNA meth
CASC3 3679 5106
CUL2 -11 2207
DAG1 98 -94
EIF4A3 509 4598
EIF4G1 4196 5766
ETF1 2407 151
FAU -1368 6877
GSPT1 -741 -1155
LDB1 -1854 1166
NCBP1 -340 5859
NCBP2 -4320 4777
PABPC1 -1115 3011
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
RBX1 1356 5883
RNPS1 -3428 537
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
SLIT1 3172 -1570
UBA52 -1313 -69
UBB 355 5059
UBC 2129 3220
UPF2 443 3840
UPF3A -3854 6963
USP33 -760 774
ZSWIM8 4061 -1421



Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
metric value
setSize 40
pMANOVA 2.01e-11
p.adjustMANOVA 6.86e-10
s.dist 0.652
s.RNA -0.628
s.meth 0.175
p.RNA 6.24e-12
p.meth 0.0564




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPS2 -4297 6975
RPS12 -4108 6331
RPS5 -3971 6072
RPS15A -3897 6112
RPS16 -3735 5981
RPS29 -3769 5602
RPS3 -4130 4599
RPS7 -4048 4408
EIF3M -2777 5836
RPS15 -2723 5623
RPS18 -3585 4163
RPS20 -4194 3461
RPS10 -3682 3925
RPS11 -3401 4225
RPS23 -4175 2986
RPS27A -4373 2589
EIF3H -2928 3706
FAU -1368 6877
EIF3L -3550 2568

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 -597 4745
EIF2S2 208 6254
EIF3A -452 5855
EIF3B -4255 -704
EIF3E -3975 503
EIF3F -2004 1471
EIF3G -1016 3038
EIF3H -2928 3706
EIF3I -957 696
EIF3J -2581 737
EIF3K -877 6636
EIF3L -3550 2568
EIF3M -2777 5836
FAU -1368 6877
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072



Signaling by Interleukins

Signaling by Interleukins
metric value
setSize 263
pMANOVA 4.95e-11
p.adjustMANOVA 1.64e-09
s.dist 0.241
s.RNA 0.214
s.meth 0.111
p.RNA 3.13e-09
p.meth 0.00214




Top 20 genes
Gene RNA meth
SOCS3 4385 6492
ITGB2 4401 6426
MAPK1 4578 6099
PTPN9 4514 6096
PTPN6 4161 6542
CRK 4125 6598
TNFRSF1B 3940 6870
GRB2 4326 6241
NOD2 3888 6610
ALOX5 4569 5386
VAV1 4015 5834
IL19 3115 7266
P4HB 3946 5718
IRS2 3595 6152
MAP2K6 4449 4792
PSMD4 3943 5314
PTK2B 4572 4529
PIK3CD 3357 6109
PSMA7 2849 6903
SMARCA4 2865 6792

Click HERE to show all gene set members

All member genes
RNA meth
AIP -518 6684
AKT1 2261 1109
ALOX5 4569 5386
APP 2164 6623
ARF1 4256 -1821
ATF1 901 2989
BATF 1388 6679
BCL2 -2865 7022
BCL2L1 1700 5970
BCL6 4635 3669
BIRC5 1558 1965
BRWD1 -2281 -349
BTRC -1609 -923
CANX 1159 3479
CAPZA1 3644 999
CASP1 1025 7031
CASP3 1520 5691
CBL 3838 1012
CCND1 -1449 1006
CCR1 3634 -1921
CD4 -2816 909
CDC42 3077 856
CDKN1A 1908 2427
CEBPD 4221 -907
CFL1 3776 1646
CHUK 3252 1111
CISH -175 4928
CNN2 3453 -418
CREB1 -1515 1422
CRK 4125 6598
CRKL 1801 5167
CSF1 -64 356
CTF1 2341 543
CUL1 -4198 -1192
CXCL2 1260 -1990
DUSP3 3162 2260
DUSP4 -775 2494
DUSP6 -1141 -1943
DUSP7 -914 722
FBXW11 1937 -1508
FOS 989 5647
FOXO1 -4379 3034
FOXO3 3778 5023
FYN -2007 2793
GAB2 4209 2390
GATA3 -4560 6274
GRB2 4326 6241
GSDMD 139 -91
GSTO1 3474 3633
HIF1A 3384 2448
HMGB1 -2719 3222
HNRNPA2B1 1073 2721
HNRNPF 452 5857
HSP90AA1 -1535 6210
HSP90B1 -644 2127
HSPA9 -4391 6551
ICAM1 388 2036
IKBKB 612 -912
IL10RA -392 5518
IL10RB 4541 -1076
IL12A -3249 -1317
IL12RB1 -1989 6632
IL12RB2 -3666 -1861
IL15 -1219 3611
IL15RA -341 -1087
IL16 -774 5458
IL17C 1369 -1130
IL17RA 4554 130
IL17RC -1660 1939
IL18BP -758 -1640
IL18R1 2772 6744
IL19 3115 7266
IL1RAP 3352 -1122
IL21R -3121 2722
IL23A -4517 7078
IL27RA 1981 6659
IL2RA -3245 6868
IL2RB -4326 7237
IL32 -3938 7268
IL4R 4114 1274
IL6R 2714 5066
IL6ST -68 1708
INPP5D 3395 55
INPPL1 4354 588
IRAK2 -1035 4686
IRAK3 4427 666
IRF4 -3445 5941
IRS1 -2377 4308
IRS2 3595 6152
ITGB2 4401 6426
JAK1 -2489 -283
JAK2 1521 6489
JUN 1097 1283
JUNB 2595 5018
LCK -4275 7246
LCP1 4071 4312
LGALS9 3873 -1462
LMNB1 4433 1051
MAP2K1 3972 1533
MAP2K3 4118 2411
MAP2K4 2808 4764
MAP2K6 4449 4792
MAP2K7 529 1764
MAP3K3 4156 3121
MAP3K7 1384 -147
MAP3K8 4618 3266
MAPK1 4578 6099
MAPK14 4535 2465
MAPK3 3753 1978
MAPK7 3913 -244
MAPK8 -3916 4554
MAPK9 -2113 157
MAPKAPK2 3308 3265
MAPKAPK3 4600 2896
MEF2A 3832 3013
MIF -2932 3355
MTAP -2661 2271
MUC1 1530 6715
MYD88 4639 1945
NFKB2 -1330 5251
NFKBIA 1880 6814
NFKBIB 2414 5574
NKIRAS1 -2478 348
NKIRAS2 4516 -1132
NOD1 -1381 -321
NOD2 3888 6610
OSM 3158 1355
P4HB 3946 5718
PAK2 3401 283
PDCD4 -4493 4220
PELI1 1650 1867
PELI2 2137 7035
PELI3 3441 -1123
PIK3CA 749 1470
PIK3CD 3357 6109
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R3 943 3645
PIM1 2662 1390
PITPNA 4148 3616
POU2F1 2852 3909
PPIA -2610 4555
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5D 2308 3470
PRKACA 4651 890
PRTN3 -4157 5621
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
PTK2B 4572 4529
PTPN11 2272 5062
PTPN12 2791 -982
PTPN13 -2382 6850
PTPN18 4432 3436
PTPN2 3465 181
PTPN23 2552 5427
PTPN4 -3616 784
PTPN6 4161 6542
PTPN7 -233 2323
PTPN9 4514 6096
RALA -2555 2302
RAP1B 2468 5968
RAPGEF1 1750 6445
RBX1 1356 5883
RELA -73 4333
RORA -4061 6933
RPLP0 -4084 4851
RPS27A -4373 2589
RPS6KA1 4529 -1859
RPS6KA2 1506 2117
RPS6KA5 -4174 1991
S1PR1 -1593 6791
SHC1 3650 3205
SIGIRR -2791 6807
SKP1 -2513 2680
SMAD3 -3344 -363
SMARCA4 2865 6792
SNRPA1 -3010 1539
SOCS1 1609 4130
SOCS2 -1186 6479
SOCS3 4385 6492
SOCS5 108 466
SOD1 -3096 1838
SOD2 2609 6134
SOS1 -1111 -1986
SOS2 3749 3699
SQSTM1 -748 658
STAT1 -4215 4970
STAT2 -1314 5933
STAT3 3745 4995
STAT4 -3864 4203
STAT5A 2844 -1545
STAT5B 3260 1495
STAT6 3810 3854
STX1A 1229 4174
STX3 3994 2712
STX4 2492 1609
STXBP2 4615 -155
SYK 4033 431
TAB2 693 6401
TALDO1 4129 4422
TBK1 1669 599
TCP1 -1621 -448
TEC 3772 170
TGFB1 1897 3769
TNF -477 -526
TNFRSF1A 4465 -1548
TNFRSF1B 3940 6870
TNIP2 2832 287
TOLLIP 3713 664
TP53 -4050 2709
TRAF6 1605 -71
TXLNA 1079 7007
TYK2 4387 4072
UBA52 -1313 -69
UBB 355 5059
UBC 2129 3220
UBE2N -757 4834
UBE2V1 -446 2792
VAMP2 -3788 -1239
VAV1 4015 5834
VEGFA 1946 87
VIM 4470 3780
VRK3 2567 2903
YES1 -1057 5198
YWHAZ 1788 4294
ZEB1 -2893 5937



Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation
metric value
setSize 133
pMANOVA 5.16e-11
p.adjustMANOVA 1.66e-09
s.dist 0.341
s.RNA 0.334
s.meth 0.0679
p.RNA 3.27e-11
p.meth 0.178




Top 20 genes
Gene RNA meth
PRKCD 4562 6360
GNG5 4320 6512
MAPK1 4578 6099
ACTN1 3787 7240
PTPN6 4161 6542
CRK 4125 6598
GRB2 4326 6241
WDR1 3821 7036
QSOX1 4653 5727
CYB5R1 4498 5881
CD63 4648 5434
RAF1 3715 6573
ALDOA 4405 5367
RAC1 4263 5541
VAV1 4015 5834
FERMT3 4471 5112
GTPBP2 4571 4515
CSK 3579 4890
P2RY1 4657 3720
RAP1A 2631 6569

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -532 567
AAMP -2521 7121
ABCC4 569 2355
ABHD12 -1857 5950
ABHD6 2336 2533
ACTN1 3787 7240
ACTN4 4018 1596
AKT1 2261 1109
ALDOA 4405 5367
ANXA5 3519 2872
APBB1IP 4261 3821
APLP2 4439 -964
APP 2164 6623
ARRB1 1355 -1278
ARRB2 4301 2913
BRPF3 432 3308
CALM1 -444 4502
CALU 3405 1962
CAP1 3857 2034
CD63 4648 5434
CDC37L1 -2940 519
CDC42 3077 856
CFL1 3776 1646
CHID1 276 1830
CRK 4125 6598
CSK 3579 4890
CYB5R1 4498 5881
DAGLB 4088 -302
DGKA -3866 7033
DGKD 2424 4806
DGKE -3765 6507
DGKG 3030 4393
DGKH -872 4127
DGKQ -377 3114
DGKZ -854 -1315
ENDOD1 -530 -639
FAM3C -4101 32
FERMT3 4471 5112
FYN -2007 2793
GNA12 -295 4303
GNA13 1819 3330
GNA15 4425 -1924
GNAI2 4039 3218
GNAI3 3078 2359
GNAQ 3823 -1832
GNB1 4127 2799
GNB2 4050 1879
GNB4 2511 1335
GNB5 -1874 6256
GNG2 1099 6500
GNG3 1539 7142
GNG4 870 6856
GNG5 4320 6512
GNG7 -2307 -499
GNGT2 511 7120
GRB2 4326 6241
GTPBP2 4571 4515
HABP4 -4540 3365
ITPR1 -1390 1789
ITPR2 2788 -44
ITPR3 -2430 2189
LCK -4275 7246
LCP2 1292 -428
MANF 167 6556
MAPK1 4578 6099
MAPK14 4535 2465
MAPK3 3753 1978
NHLRC2 -1815 -59
OLA1 -2243 6473
P2RY1 4657 3720
PCYOX1L -161 2972
PDPK1 3242 346
PFN1 3107 3814
PHACTR2 1287 -1839
PIK3CA 749 1470
PIK3CG 3446 2051
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R3 943 3645
PIK3R5 2731 4483
PLCG2 4027 2803
PLEK 1612 -567
PPIA -2610 4555
PRKCA -898 6894
PRKCB 3189 4964
PRKCD 4562 6360
PRKCE 3011 -1185
PRKCH -4304 2578
PRKCQ -4200 4208
PRKCZ -2369 -1376
PSAP 3330 628
PTK2 147 -475
PTPN1 4262 699
PTPN11 2272 5062
PTPN6 4161 6542
QSOX1 4653 5727
RAC1 4263 5541
RAC2 3032 4577
RAF1 3715 6573
RAP1A 2631 6569
RAP1B 2468 5968
RASGRP1 -4180 5888
RASGRP2 -2424 -413
RHOA 3580 4033
RHOB 2885 2346
RHOG 4271 3664
SCCPDH 4059 1126
SHC1 3650 3205
SOD1 -3096 1838
SOS1 -1111 -1986
SRC -2558 -1476
SRGN 3830 1395
STX4 2492 1609
STXBP2 4615 -155
STXBP3 2569 199
SYK 4033 431
TAGLN2 889 1679
TEX264 -1536 5266
TGFB1 1897 3769
TGFB2 2115 -1899
TGFB3 -2827 -978
TLN1 3997 -983
TMX3 -1365 -543
TOR4A 4473 -1620
TUBA4A 2938 4105
VAV1 4015 5834
VAV2 975 4134
VAV3 3114 -685
VCL 2144 3614
VEGFA 1946 87
VTI1B 3343 3178
WDR1 3821 7036
YWHAZ 1788 4294



rRNA modification in the nucleus and cytosol

rRNA modification in the nucleus and cytosol
metric value
setSize 47
pMANOVA 1.67e-10
p.adjustMANOVA 5.23e-09
s.dist 0.573
s.RNA -0.56
s.meth 0.123
p.RNA 3.18e-11
p.meth 0.144




Top 20 genes
Gene RNA meth
RPS2 -4297 6975
SNU13 -3683 7054
WDR43 -4181 5510
NOP2 -3578 6403
PNO1 -3412 6496
MPHOSPH10 -3876 5401
RCL1 -3250 6343
UTP15 -4042 5063
WDR75 -4429 4614
RPS7 -4048 4408
UTP20 -3101 5085
HEATR1 -3022 5201
IMP3 -2832 5542
NOL6 -3321 4557
UTP6 -3759 3932
WDR36 -1954 6601
NHP2 -2631 4827
NOL11 -4484 2571
IMP4 -2963 3786
PWP2 -2097 5076

Click HERE to show all gene set members

All member genes
RNA meth
BMS1 -4317 -1755
DCAF13 -3178 862
DDX47 -4147 -50
DDX49 1400 5582
DDX52 621 -204
DHX37 -1827 4195
FBL -4488 -43
FCF1 169 6763
GAR1 -3086 879
HEATR1 -3022 5201
IMP3 -2832 5542
IMP4 -2963 3786
KRR1 -3265 -1952
MPHOSPH10 -3876 5401
NHP2 -2631 4827
NOC4L 554 -799
NOL11 -4484 2571
NOL6 -3321 4557
NOP10 4120 2081
NOP14 -4322 2209
NOP2 -3578 6403
NOP56 -4212 996
NOP58 -4541 1333
PDCD11 -2635 3455
PNO1 -3412 6496
PWP2 -2097 5076
RCL1 -3250 6343
RPS2 -4297 6975
RPS6 -4362 361
RPS7 -4048 4408
RPS9 640 627
RRP7A -2020 1582
RRP9 -3748 653
SNU13 -3683 7054
TBL3 262 5418
THUMPD1 -4407 -871
TRMT112 -847 1929
TSR3 505 6370
UTP15 -4042 5063
UTP18 1320 3357
UTP20 -3101 5085
UTP3 -1850 3926
UTP6 -3759 3932
WDR3 -2885 -1387
WDR36 -1954 6601
WDR43 -4181 5510
WDR75 -4429 4614



Gene expression (Transcription)

Gene expression (Transcription)
metric value
setSize 1003
pMANOVA 2.18e-10
p.adjustMANOVA 6.67e-09
s.dist 0.133
s.RNA -0.107
s.meth 0.0794
p.RNA 3.21e-08
p.meth 3.87e-05




Top 20 genes
Gene RNA meth
RGCC -4473 7232
TCF7 -4594 6951
NUP88 -4340 7084
NDC1 -4564 6482
GATA3 -4560 6274
ZNF517 -4143 6892
FBXO32 -4364 6488
RORA -4061 6933
RPA1 -4416 6282
ZNF681 -4145 6567
CTLA4 -3797 7091
WRN -4244 6296
NFATC2 -3694 7159
DGCR8 -3697 6998
ZNF530 -4451 5650
ZNF563 -3816 6436
ZNF75A -3459 7086
EPC1 -3640 6722
POLR3H -4357 5546
PLD6 -4381 5490

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1256 1467
ABL1 2124 2469
ACTB 4254 5447
ACTL6A -3069 -311
AEBP2 -2506 6374
AFF4 1651 -209
AGO1 3289 7140
AGO2 2116 7196
AGO3 899 3465
AKT1 2261 1109
AKT2 1896 5431
ALYREF -801 6737
ANAPC1 -4431 2990
ANAPC10 -653 -1326
ANAPC11 1335 3188
ANAPC15 3069 6483
ANAPC16 -3056 6729
ANAPC2 -1459 2865
ANAPC4 -998 -687
ANAPC5 -3133 5213
ANAPC7 182 1873
ANG 3549 6526
APAF1 3293 -809
ARID1A 3661 1914
ARID1B 217 4017
ARID2 1248 1091
ARID3A 3941 2011
ARID4B 28 2402
ASH2L 3309 3075
ATAD2 -1741 142
ATM -3403 3035
ATR -2058 930
ATRIP -1360 1869
ATXN3 -243 2715
AURKA 2351 4012
AURKB 699 5274
AUTS2 -1924 -1353
AXIN1 -1113 -858
BANP 1037 195
BARD1 1455 5972
BAX 1873 1161
BAZ1B 0 1271
BAZ2A 3042 3649
BBC3 -579 5286
BCDIN3D 1112 3632
BCL2L11 3454 5664
BCL6 4635 3669
BDP1 -1356 6073
BID 2718 5466
BIRC5 1558 1965
BLM -1986 5263
BMI1 -3597 -805
BNIP3L 1616 4412
BRCA1 2494 1586
BRD1 -2346 7212
BRD2 -74 5081
BRD7 -695 3924
BRF1 -615 2464
BRF2 -1957 2460
BRIP1 -3102 63
BRPF1 738 5935
BRPF3 432 3308
BTG1 -2416 5954
BTG2 -2077 5261
CALM1 -444 4502
CAMK2D -4472 -529
CAMK2G 891 6718
CAMK4 -4589 2759
CASC3 3679 5106
CASP1 1025 7031
CASP10 347 -1807
CASP6 -3320 -556
CAT 3953 -1206
CAV1 779 4592
CBFB 185 5862
CBX3 809 2289
CBX4 2670 278
CBX6 1804 3612
CBX8 927 4611
CCNA2 651 4428
CCNB1 259 1332
CCNC -2845 4188
CCND1 -1449 1006
CCND2 -3934 -1567
CCND3 4181 4156
CCNE1 -1399 5956
CCNE2 1238 5659
CCNG1 -2589 857
CCNG2 3564 2810
CCNH 723 1260
CCNK 2940 6593
CCNT1 -1482 1761
CDC16 -1567 3340
CDC23 -3790 1597
CDC25C 2001 5507
CDC40 1743 7125
CDC7 -1721 6399
CDC73 2159 5719
CDK1 -959 1888
CDK12 2045 5160
CDK13 746 5779
CDK2 -1366 2965
CDK4 -4024 4919
CDK5 4265 3491
CDK5R1 469 7124
CDK6 -1861 562
CDK7 1419 4034
CDK8 1491 5795
CDK9 1936 3144
CDKN1A 1908 2427
CDKN1B -1167 3367
CDKN2A 21 3478
CEBPB 4548 337
CENPJ -3899 4073
CHD3 -2622 6050
CHD4 107 640
CHEK1 -2434 51
CHEK2 -309 5331
CITED2 3160 1266
CITED4 332 -93
CLP1 1923 2378
CNOT1 1452 4959
CNOT10 -991 3018
CNOT11 494 3729
CNOT3 3178 3093
CNOT4 1065 6001
CNOT6 2589 4653
CNOT6L -3586 6262
CNOT7 -3901 -58
CNOT8 980 5798
COX11 -3999 2566
COX14 -2045 6534
COX16 -3188 1183
COX19 -1879 47
COX20 -3217 4917
COX4I1 -105 6762
COX5A 1113 -152
COX5B 1733 -52
COX6A1 2037 3077
COX6B1 2935 564
COX6C -2017 2304
COX7A2L 1364 5084
COX7C -1809 1883
COX8A 2964 2226
CPSF1 -206 1083
CPSF2 2562 988
CPSF3 2618 5337
CPSF4 -1537 1770
CRADD 1220 1024
CRCP 2587 4708
CREB1 -1515 1422
CREBBP 2992 892
CSNK2A2 2634 5736
CSNK2B 2032 4743
CSTF1 -3014 6209
CTDP1 3527 1002
CTLA4 -3797 7091
CTNNB1 3708 5070
CTR9 556 -440
CTSL 4053 3028
CTSV -1434 5170
CUL1 -4198 -1192
CYCS -1705 5369
DAXX -792 1574
DDB2 -362 -1223
DDIT3 2252 5192
DDIT4 1416 3702
DDX21 -423 3312
DEK -1277 6182
DGCR8 -3697 6998
DICER1 3925 6637
DNA2 -2517 1296
DNMT1 -4316 4753
DNMT3A -747 -1253
DNMT3B 1281 3249
DPY30 -115 1423
DYRK2 -4387 4997
E2F1 2395 3145
E2F4 1792 1015
E2F5 -2715 4181
E2F6 -3890 4027
E2F7 -2039 3875
E2F8 310 149
EAF1 2581 -327
EED -2776 3088
EHMT1 1109 2699
EHMT2 -989 3889
EIF4A3 509 4598
ELAC2 -2081 275
ELF1 -98 -1467
ELF2 2690 978
ELL 3009 1501
ELL2 1665 167
ELL3 1893 2028
EP300 3773 4901
EPC1 -3640 6722
ERBB2 -2433 4160
ERCC2 2316 1849
ERCC3 1189 1487
ERCC6 -2616 2399
ESR2 -3284 4784
ESRRA 3477 5421
EXO1 -1084 4438
EZH2 -1432 2695
FANCC -160 1401
FANCD2 -4141 4786
FANCI -3575 1261
FAS 437 825
FBXO32 -4364 6488
FBXW7 -468 6667
FIP1L1 -668 3099
FKBP5 4458 -681
FOS 989 5647
FOXO1 -4379 3034
FOXO3 3778 5023
FYTTD1 -2696 5127
FZR1 1357 2326
GADD45A 4523 2249
GATA3 -4560 6274
GATAD2A 2436 189
GATAD2B 2076 5595
GLS -4575 2305
GPAM -3583 81
GPI 2530 5674
GPS2 896 6830
GSK3B 2544 4908
GSR 4497 4125
GTF2A1 -425 1479
GTF2A2 752 286
GTF2B 398 -1154
GTF2E2 2475 4885
GTF2F1 2368 558
GTF2F2 2169 5307
GTF2H3 -3711 5705
GTF2H4 -291 5240
GTF2H5 -620 3417
GTF3A -3991 2860
GTF3C1 2151 4216
GTF3C2 -1484 2569
GTF3C3 -561 75
GTF3C4 -2773 7164
GTF3C5 183 3843
GTF3C6 703 3594
HDAC1 239 3287
HDAC10 852 4924
HDAC11 1885 6084
HDAC2 -2809 5864
HDAC3 1870 7116
HDAC4 4413 887
HDAC5 1171 3068
HDAC7 2654 -487
HENMT1 -971 5055
HIPK1 3176 4886
HIPK2 3934 7093
HIVEP3 941 6938
HSP90AA1 -1535 6210
HSPD1 -4397 3524
HUS1 1449 329
ICE2 -3394 5838
IL2RA -3245 6868
ING2 -625 1059
ING5 -4450 4790
INTS1 2234 -478
INTS10 16 16
INTS12 1072 3211
INTS2 1195 -1195
INTS3 3800 4013
INTS4 -1715 5759
INTS5 -2273 4248
INTS6 1626 1940
INTS7 608 4770
INTS8 1406 4191
INTS9 -766 200
IPO8 2323 3771
ITCH 2375 4854
ITGA4 -3219 -394
ITGA5 3809 3467
ITGAL 1255 7038
IWS1 3257 3898
JARID2 3485 -106
JMY -3648 5163
JUN 1097 1283
JUNB 2595 5018
KAT2A -3982 1343
KAT2B 726 4028
KAT5 1234 1952
KCTD1 2000 2461
KCTD6 1857 -621
KMT2A -2660 7244
KMT2C 2218 6984
KMT2D 3314 6495
KMT2E 193 7066
KRAS 2127 3139
L3MBTL2 -3598 2967
LAMTOR1 3516 -1589
LAMTOR2 2924 -1342
LAMTOR3 1845 957
LAMTOR4 2085 7000
LAMTOR5 3327 -881
LBR 3297 2128
LDB1 -1854 1166
LEO1 -276 4252
LMO2 3765 2867
LRPPRC -4502 1082
LSM10 2249 1062
LSM11 -3997 -211
MAF -2161 403
MAML1 3921 1442
MAML2 -2945 4627
MAML3 4280 3460
MAP2K6 4449 4792
MAPK1 4578 6099
MAPK14 4535 2465
MAPK3 3753 1978
MAPKAP1 1572 5908
MAX -50 1615
MBD2 2748 -303
MBD3 -2339 6240
MDC1 -2993 4410
MDM2 2097 2095
MDM4 466 5729
MEAF6 -3309 3083
MED1 -348 4473
MED10 -3710 2697
MED13 230 6580
MED15 -325 5803
MED16 1422 -884
MED17 -983 3538
MED20 3265 180
MED23 665 3755
MED24 410 5183
MED25 2987 565
MED26 2277 3021
MED27 -1109 1874
MED30 -1056 4136
MED31 -935 2499
MED4 -831 127
MED6 -2728 6745
MED7 409 4941
MED8 3216 1234
MEN1 -2073 1903
MGA -2271 -909
MLLT1 4084 4011
MLLT3 -4333 1331
MLST8 -375 2258
MNAT1 -2524 1516
MOV10 -2344 -1882
MSH2 -2948 5927
MTA2 1016 5579
MTA3 -2954 5162
MTERF1 -1839 5746
MTF2 -2196 3354
MTOR 616 3900
MYB -1717 -449
MYBBP1A -4378 5091
MYBL1 -2374 3880
NABP1 4236 6497
NABP2 566 -1674
NBN 499 4478
NCBP1 -340 5859
NCBP2 -4320 4777
NCOR1 2997 -530
NCOR2 4583 -1609
NDC1 -4564 6482
NDRG1 3908 1648
NDUFA4 1517 4279
NEDD4L 3426 -1080
NELFA -1043 3055
NELFB 627 -649
NELFCD -1873 6416
NELFE 2357 1529
NFATC2 -3694 7159
NFE2 4620 -1804
NFIA 3112 264
NFIC 4288 -1029
NFIX -1145 424
NFYA 2338 102
NFYB -4555 1588
NFYC 4173 226
NOP2 -3578 6403
NOTCH1 3629 6291
NOTCH4 4055 4962
NR1D1 -4064 5907
NR1D2 -4256 520
NR1H2 3638 6463
NR1H3 330 6206
NR2C1 -3009 4894
NR2C2 -624 7005
NR2C2AP -4195 3955
NR3C1 353 3509
NR3C2 -4419 5083
NR4A1 -990 1085
NR4A2 -524 3570
NR4A3 -705 1460
NR6A1 3388 -1396
NRBP1 2668 5632
NUDT21 -3302 4271
NUP107 -3568 6301
NUP133 -2062 935
NUP153 96 4344
NUP155 -2910 3043
NUP160 -3599 1293
NUP188 -3388 2922
NUP205 -3151 1670
NUP210 -1503 690
NUP214 3964 4369
NUP35 -4376 -557
NUP37 -837 3398
NUP43 -3605 6346
NUP50 935 6706
NUP54 -2949 831
NUP62 -899 4609
NUP85 -1286 4518
NUP88 -4340 7084
NUP93 -2587 2006
NUP98 2030 -747
PABPN1 -645 3061
PAF1 1741 7080
PAPOLA 1833 4317
PARP1 -3618 3582
PBRM1 2049 3867
PCBP4 -3215 6284
PCGF5 -4000 1347
PCGF6 -381 2693
PCNA -2931 4383
PDPK1 3242 346
PHAX -3500 5545
PHC1 -3734 -1213
PHC2 4552 4887
PHC3 -883 4977
PHF1 -3777 1265
PHF19 1782 -358
PHF20 -2003 115
PIDD1 -2417 -453
PIN1 214 4014
PINK1 4213 -715
PIP4K2A 144 3045
PIP4K2B -2458 1071
PIP4K2C 386 223
PLAGL1 2694 -782
PLD6 -4381 5490
PLK2 206 5974
PLK3 2435 3378
PMAIP1 -4516 -1394
PML -294 4575
PMS2 -1590 5491
POLDIP3 3991 3182
POLR1A -1591 131
POLR1B -3849 5607
POLR1C -4031 5329
POLR1D 589 6782
POLR1E -4481 1955
POLR2A 2854 4046
POLR2B -1272 5563
POLR2C -184 6356
POLR2D -2801 -614
POLR2E 1754 3712
POLR2F 1457 509
POLR2G 1427 1604
POLR2H -2461 6299
POLR2I -1497 5657
POLR2K -1891 3853
POLR3A 1126 5226
POLR3C -1707 3978
POLR3D -3951 1967
POLR3E -3745 1113
POLR3F -3279 -1023
POLR3G -2957 6661
POLR3GL -987 204
POLR3H -4357 5546
POLR3K -734 891
POLRMT -3581 2155
POM121 -48 4681
POM121C -623 2061
POU2F1 2852 3909
POU2F2 771 6367
PPARD -3366 -791
PPARGC1B -8 1449
PPM1A 3338 -136
PPM1D 2720 2649
PPP1R13B -3124 6430
PPP1R13L -2258 6545
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5C -2002 7074
PRDM1 -1513 1144
PRDX1 1306 510
PRDX2 -1544 2503
PRDX5 3517 4022
PRKAA1 841 607
PRKAB1 2545 -840
PRKAB2 -2142 3091
PRKACA 4651 890
PRKAG1 2830 -1055
PRKAG2 -691 1021
PRKCB 3189 4964
PRKCQ -4200 4208
PRKRA -4447 2110
PRMT1 -3615 2118
PRMT5 542 2005
PRR5 -2760 -347
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
PTEN 3653 4815
PTPN1 4262 699
PTPN11 2272 5062
PTPN4 -3616 784
RABGGTA 737 4691
RABGGTB -2887 7207
RAD1 -4466 -31
RAD17 -3681 5343
RAD50 -1225 247
RAD51 -1352 5267
RAD51D -2235 4330
RAD9A -3117 5967
RAD9B 2305 -246
RAE1 1714 2634
RAN -3671 1483
RANBP2 -405 5165
RARA 4372 2132
RARG -1393 297
RB1 3804 1119
RBBP4 -2172 4061
RBBP5 -378 2829
RBBP8 2211 1329
RBL1 -2914 5256
RBL2 -4148 -479
RBM14 -546 5599
RBPJ 3988 1033
RBX1 1356 5883
RELA -73 4333
RFC2 1888 4262
RFC3 -4188 2737
RFC4 -3903 5077
RFC5 -3185 4211
RFFL 1192 1095
RGCC -4473 7232
RHEB 1519 6311
RHNO1 -2632 511
RICTOR -2029 2833
RING1 -1409 1003
RMI2 -102 -1676
RNF111 2486 6049
RNF2 95 2513
RNF34 -38 1414
RNGTT 1383 14
RNMT -3181 6871
RNPS1 -3428 537
RORA -4061 6933
RPA1 -4416 6282
RPA3 -4077 2526
RPAP2 -1069 2798
RPRD1A 550 3830
RPRD2 -1032 4610
RPS27A -4373 2589
RPTOR -402 5596
RRAGA 3399 6806
RRAGC 605 5284
RRAGD 3035 -1656
RRM2 -907 4440
RRM2B 1093 1208
RRN3 -4344 2204
RTF1 1346 6570
RUNX1 4212 193
RUNX2 -4257 2447
RUNX3 -2741 6760
RYBP 2311 6819
SAP130 3424 5020
SAP18 528 5887
SAP30 3571 1163
SAP30BP 295 5733
SAP30L 2136 5024
SATB2 3511 2932
SCMH1 -3931 95
SCO1 -2204 6273
SCO2 -1458 3284
SEC13 2700 6211
SEH1L -4285 3577
SESN1 -2203 4661
SESN2 3762 -84
SESN3 -1920 4705
SETD1A -2313 -815
SETD1B 2722 2093
SETD9 -1774 -411
SFN 639 -1779
SGK1 -2490 -1194
SIN3A -3277 3819
SIN3B 731 -419
SIRT1 -3168 6547
SIRT3 -860 661
SKI -1509 2897
SKIL 2418 3946
SKP1 -2513 2680
SKP2 -683 1707
SLBP -1040 428
SLC2A3 4316 -1211
SLC38A9 1891 6117
SLU7 134 1094
SMAD1 4662 206
SMAD2 2180 1865
SMAD3 -3344 -363
SMAD4 -1376 -1925
SMAD6 4373 5259
SMAD7 25 1420
SMARCA2 647 6063
SMARCA4 2865 6792
SMARCA5 -1885 -466
SMARCB1 -994 6568
SMARCC1 -1676 2301
SMARCC2 2028 5960
SMARCD1 -2068 -130
SMARCD2 3086 3941
SMARCE1 -1205 3183
SMURF1 2253 6934
SMURF2 -2298 3523
SMYD2 -3239 6312
SNAPC1 -1786 2196
SNAPC2 2727 -575
SNAPC3 1344 685
SNAPC4 -57 5250
SNAPC5 -307 4907
SNRPB -1600 4948
SNRPD3 -2538 -377
SNRPE -3729 3730
SNRPG 210 3411
SNW1 1166 2517
SOCS3 4385 6492
SOCS4 -1114 4739
SOD2 2609 6134
SP1 3722 4865
SPI1 4588 -1985
SRC -2558 -1476
SREBF1 798 2475
SRRM1 -799 3813
SRRT -2226 1308
SRSF11 -3950 -51
SRSF2 -2454 212
SRSF3 -2156 -1225
SRSF4 2517 6867
SRSF7 -2997 618
SRSF9 3244 745
SSB -3519 4891
SSRP1 -4209 770
SSU72 1737 2386
STAT1 -4215 4970
STK11 -81 750
STUB1 -996 2320
SUDS3 1064 1432
SUMO1 1392 3368
SUPT16H -4404 4839
SUPT4H1 1139 5918
SUPT5H -1388 2020
SUPT6H 1861 1349
SURF1 1168 -170
SYMPK 402 2886
TACO1 -1244 -240
TAF10 3591 5288
TAF11 41 882
TAF12 3307 3413
TAF13 3249 3627
TAF15 -1869 4237
TAF1A -3448 4832
TAF1B -1059 -322
TAF1C 20 1350
TAF1D -3436 5423
TAF2 1094 292
TAF3 -2114 1363
TAF4 497 554
TAF4B -3832 4706
TAF5 -2301 3430
TAF6 280 6843
TAF7 1115 455
TAF8 2081 5526
TAF9 -1964 4396
TARBP2 -1743 3789
TBL1XR1 1666 2633
TCEA1 -2578 4154
TCF12 833 -542
TCF3 -1996 -374
TCF7 -4594 6951
TCF7L2 4350 1660
TDG 1630 -1070
TDRKH -2849 817
TET1 -3469 5294
TET3 3774 7238
TFAM -4213 1500
TFAP2E -321 -857
TFDP1 3228 2953
TFDP2 -3622 -1478
TGFA 4463 4632
TGFB1 1897 3769
TGIF1 -2836 -390
TGIF2 -3817 -1905
THOC1 -3385 6023
THOC5 4072 3364
THOC7 130 5594
THRA -731 761
TIGAR 2301 5175
TMEM219 -345 1282
TNFRSF10A -1036 2821
TNFRSF10B 3351 -670
TNFRSF10D 2443 3086
TNKS1BP1 -3635 3401
TNRC6A 119 5197
TNRC6B 110 7059
TOP3A 3714 3073
TOPBP1 149 3545
TP53 -4050 2709
TP53BP2 3443 -1534
TP53I3 4675 2407
TP53INP1 2419 3584
TP53RK -3369 2847
TPR -1423 4616
TPX2 1510 261
TRIAP1 -2378 6160
TRIM28 -3247 3596
TRIM33 -169 6680
TSC1 479 4696
TSC2 1480 3951
TSN -2133 4855
TSNAX 395 7136
TTC5 -1793 3420
TTF1 -1291 3536
TXN 3518 -1735
TXNIP -1950 6154
TXNRD1 3831 -1402
U2AF1 2203 1030
U2AF1L4 -793 5616
U2AF2 177 6132
UBA52 -1313 -69
UBB 355 5059
UBC 2129 3220
UBE2C 1233 4535
UBE2D1 3526 2741
UBE2D3 3214 3005
UBE2E1 -1112 2408
UBE2I -873 5796
UBE2S 1641 -706
UBTF -3544 1855
UHRF1 1152 6173
USP7 2170 3259
VDR 4654 3980
VEGFA 1946 87
WDR33 -170 3468
WDR5 -824 1100
WDR61 -887 1522
WRN -4244 6296
WWOX -3993 4712
WWP1 -4510 479
XPO5 -3470 5412
YAF2 -1628 -1487
YEATS4 -3627 4457
YES1 -1057 5198
YWHAB 1621 2152
YWHAE 3368 1288
YWHAG 4167 1919
YWHAH 3924 -1276
YWHAQ -1781 3225
YWHAZ 1788 4294
YY1 -1982 1468
ZC3H8 -4486 1561
ZFHX3 2269 6885
ZFP1 -3742 2171
ZFP14 -1735 5520
ZFP28 -4091 2617
ZFP30 -2255 37
ZFP37 -3113 5350
ZFP90 -2512 4023
ZFPM1 -1716 6831
ZIK1 -4370 1200
ZKSCAN1 1241 3832
ZKSCAN3 620 -582
ZKSCAN4 602 1247
ZKSCAN5 2862 732
ZKSCAN8 -2510 -1984
ZNF10 -2820 5984
ZNF101 -3127 5649
ZNF136 -4437 1381
ZNF138 -4206 2889
ZNF14 -4062 2143
ZNF140 -2802 5707
ZNF141 -2906 5326
ZNF143 2128 5194
ZNF155 188 3581
ZNF160 -703 -597
ZNF169 -717 -198
ZNF17 -2574 4405
ZNF175 -2362 3286
ZNF18 3039 -140
ZNF180 -3414 2630
ZNF184 -3531 2160
ZNF189 358 1728
ZNF19 -1353 -906
ZNF2 -1754 2263
ZNF20 1677 4018
ZNF200 440 5252
ZNF202 -4187 -391
ZNF211 -3579 5488
ZNF212 -3621 1817
ZNF213 3697 2868
ZNF215 1415 -1505
ZNF221 -574 -1001
ZNF222 228 3892
ZNF223 -2191 880
ZNF224 -2242 2025
ZNF226 -3003 3324
ZNF227 -1875 808
ZNF23 -3282 -45
ZNF233 -1697 -1823
ZNF234 -2265 6392
ZNF235 -3380 -827
ZNF248 -3917 3065
ZNF25 1080 2002
ZNF250 -1310 720
ZNF253 -3554 5994
ZNF257 -2941 6731
ZNF26 -2675 335
ZNF264 -773 -325
ZNF268 -1747 717
ZNF274 -2381 -269
ZNF282 3259 820
ZNF286A -4232 5052
ZNF287 -4413 867
ZNF3 -2743 3563
ZNF302 -4355 2690
ZNF324 -1312 4648
ZNF324B -1223 3238
ZNF331 -3976 -492
ZNF333 3010 3278
ZNF337 -4270 956
ZNF33A -1961 656
ZNF33B -4562 4399
ZNF34 -417 486
ZNF343 -2897 837
ZNF354A 2024 4628
ZNF354C -4053 439
ZNF382 -1385 6294
ZNF394 1299 1889
ZNF398 301 4259
ZNF417 -1935 6888
ZNF418 -1033 -1273
ZNF419 -3688 -1243
ZNF420 -4532 1738
ZNF425 -1530 6237
ZNF426 -376 -356
ZNF43 -3660 5317
ZNF430 -3468 -1128
ZNF431 -3715 5327
ZNF432 -3820 4336
ZNF436 -687 3369
ZNF440 -1588 6886
ZNF443 482 174
ZNF445 3494 322
ZNF446 -3319 676
ZNF461 -3420 2022
ZNF468 3226 -1501
ZNF470 -2676 5113
ZNF480 -3163 3110
ZNF483 -2992 3488
ZNF484 -1505 -1057
ZNF490 1688 4420
ZNF492 -1679 2700
ZNF496 -2351 2746
ZNF500 -1691 2619
ZNF506 -2479 1927
ZNF517 -4143 6892
ZNF528 -3098 -1161
ZNF529 -3580 6135
ZNF530 -4451 5650
ZNF540 -3882 1989
ZNF546 -1245 4961
ZNF547 -399 5028
ZNF549 -4406 3573
ZNF550 -3357 -650
ZNF552 2942 3735
ZNF554 -3859 3039
ZNF559 -3795 3388
ZNF561 -1034 3917
ZNF563 -3816 6436
ZNF564 -1228 5905
ZNF566 -4329 2789
ZNF567 -4111 4984
ZNF568 -3614 -177
ZNF569 -1922 1805
ZNF570 -3353 -836
ZNF571 -3280 6813
ZNF573 -1849 1491
ZNF582 -3177 2353
ZNF583 -3888 230
ZNF584 -2445 -1262
ZNF585A -751 6258
ZNF585B -1695 3175
ZNF587 914 4918
ZNF589 -238 5516
ZNF596 -2155 -1900
ZNF597 -2902 3305
ZNF600 -2186 -1258
ZNF605 -1864 -1067
ZNF606 -2562 3490
ZNF610 -1349 4541
ZNF611 1262 2480
ZNF613 2009 6560
ZNF614 -2764 6322
ZNF615 -150 2660
ZNF619 478 -1439
ZNF620 -1826 -1051
ZNF621 -1480 1639
ZNF624 -581 19
ZNF627 -69 268
ZNF641 543 -1172
ZNF655 195 5619
ZNF664 -3629 1404
ZNF665 -578 3845
ZNF668 1146 -545
ZNF670 -1279 -578
ZNF671 -3647 1792
ZNF677 -2541 2486
ZNF678 -3268 3886
ZNF681 -4145 6567
ZNF684 -607 3999
ZNF688 -1489 1886
ZNF689 -1215 2936
ZNF691 770 2013
ZNF692 -1897 1658
ZNF696 -3973 -563
ZNF70 -1611 399
ZNF700 -220 1456
ZNF701 1430 2213
ZNF703 -1394 -229
ZNF706 -2833 -1329
ZNF707 -2769 977
ZNF708 -2656 1382
ZNF709 -1900 6111
ZNF710 4259 -1778
ZNF713 -236 -703
ZNF714 -1237 5273
ZNF717 -618 566
ZNF736 -2651 6094
ZNF737 -2872 2021
ZNF74 -4010 4957
ZNF740 -3398 5117
ZNF746 4010 512
ZNF747 275 6503
ZNF749 -3565 -1833
ZNF75A -3459 7086
ZNF761 -3326 -599
ZNF764 258 6186
ZNF77 -1003 179
ZNF771 -2505 547
ZNF772 -2329 5398
ZNF774 2360 4930
ZNF775 1755 2200
ZNF776 560 5899
ZNF777 -2249 4582
ZNF778 598 5260
ZNF782 -2288 -705
ZNF785 -1788 1396
ZNF786 -2190 -224
ZNF79 963 2360
ZNF790 -2292 1406
ZNF791 -806 6431
ZNF792 -3120 332
ZNF793 -3383 1232
ZNF799 -2499 3846
ZNF839 1435 -1105
ZNF92 -1993 3537
ZSCAN25 -3094 7058



Translation initiation complex formation

Translation initiation complex formation
metric value
setSize 47
pMANOVA 5.71e-10
p.adjustMANOVA 1.7e-08
s.dist 0.561
s.RNA -0.534
s.meth 0.172
p.RNA 2.48e-10
p.meth 0.0415




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPS2 -4297 6975
RPS12 -4108 6331
RPS5 -3971 6072
RPS15A -3897 6112
RPS16 -3735 5981
RPS29 -3769 5602
EIF4B -3517 5587
RPS3 -4130 4599
RPS7 -4048 4408
EIF3M -2777 5836
EIF4A2 -4298 3601
RPS15 -2723 5623
RPS18 -3585 4163
RPS20 -4194 3461
RPS10 -3682 3925
RPS11 -3401 4225
RPS23 -4175 2986
RPS27A -4373 2589
EIF3H -2928 3706

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 -597 4745
EIF2S2 208 6254
EIF3A -452 5855
EIF3B -4255 -704
EIF3E -3975 503
EIF3F -2004 1471
EIF3G -1016 3038
EIF3H -2928 3706
EIF3I -957 696
EIF3J -2581 737
EIF3K -877 6636
EIF3L -3550 2568
EIF3M -2777 5836
EIF4A1 1909 881
EIF4A2 -4298 3601
EIF4B -3517 5587
EIF4E 577 6721
EIF4G1 4196 5766
EIF4H 2816 -1988
FAU -1368 6877
PABPC1 -1115 3011
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072



Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
metric value
setSize 48
pMANOVA 1.05e-09
p.adjustMANOVA 2.97e-08
s.dist 0.548
s.RNA -0.518
s.meth 0.176
p.RNA 5.29e-10
p.meth 0.0347




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPS2 -4297 6975
RPS12 -4108 6331
RPS5 -3971 6072
RPS15A -3897 6112
RPS16 -3735 5981
RPS29 -3769 5602
EIF4B -3517 5587
RPS3 -4130 4599
RPS7 -4048 4408
EIF3M -2777 5836
EIF4A2 -4298 3601
RPS15 -2723 5623
RPS18 -3585 4163
RPS20 -4194 3461
RPS10 -3682 3925
RPS11 -3401 4225
RPS23 -4175 2986
RPS27A -4373 2589
EIF3H -2928 3706

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 -597 4745
EIF2S2 208 6254
EIF3A -452 5855
EIF3B -4255 -704
EIF3E -3975 503
EIF3F -2004 1471
EIF3G -1016 3038
EIF3H -2928 3706
EIF3I -957 696
EIF3J -2581 737
EIF3K -877 6636
EIF3L -3550 2568
EIF3M -2777 5836
EIF4A1 1909 881
EIF4A2 -4298 3601
EIF4B -3517 5587
EIF4E 577 6721
EIF4EBP1 1003 4398
EIF4G1 4196 5766
EIF4H 2816 -1988
FAU -1368 6877
PABPC1 -1115 3011
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072



Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
metric value
setSize 47
pMANOVA 1.05e-09
p.adjustMANOVA 2.97e-08
s.dist 0.553
s.RNA -0.524
s.meth 0.178
p.RNA 5.28e-10
p.meth 0.0349




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPS2 -4297 6975
RPS12 -4108 6331
RPS5 -3971 6072
RPS15A -3897 6112
RPS16 -3735 5981
RPS29 -3769 5602
EIF4B -3517 5587
RPS3 -4130 4599
RPS7 -4048 4408
EIF3M -2777 5836
EIF4A2 -4298 3601
RPS15 -2723 5623
RPS18 -3585 4163
RPS20 -4194 3461
RPS10 -3682 3925
RPS11 -3401 4225
RPS23 -4175 2986
RPS27A -4373 2589
EIF3H -2928 3706

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 -597 4745
EIF2S2 208 6254
EIF3A -452 5855
EIF3B -4255 -704
EIF3E -3975 503
EIF3F -2004 1471
EIF3G -1016 3038
EIF3H -2928 3706
EIF3I -957 696
EIF3J -2581 737
EIF3K -877 6636
EIF3L -3550 2568
EIF3M -2777 5836
EIF4A1 1909 881
EIF4A2 -4298 3601
EIF4B -3517 5587
EIF4E 577 6721
EIF4G1 4196 5766
EIF4H 2816 -1988
EIF5 1036 4313
FAU -1368 6877
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072



Diseases of signal transduction by growth factor receptors and second messengers

Diseases of signal transduction by growth factor receptors and second messengers
metric value
setSize 264
pMANOVA 2.86e-09
p.adjustMANOVA 7.91e-08
s.dist 0.22
s.RNA 0.207
s.meth 0.0759
p.RNA 9.51e-09
p.meth 0.0353




Top 20 genes
Gene RNA meth
KSR1 4237 7147
MAPK1 4578 6099
GRB2 4326 6241
APH1B 3616 6785
RAF1 3715 6573
RAC1 4263 5541
VAV1 4015 5834
SPRED2 4192 5462
NOTCH1 3629 6291
CUX1 4623 4795
IRS2 3595 6152
PSMD4 3943 5314
TGFA 4463 4632
PSEN1 4153 4955
PIK3CD 3357 6109
BIN2 3734 5390
PSMA7 2849 6903
BCL2L11 3454 5664
FOXO3 3778 5023
CTNNB1 3708 5070

Click HERE to show all gene set members

All member genes
RNA meth
ADAM10 3893 2760
ADAM17 4453 4155
AGGF1 2533 889
AGK -3770 492
AGTRAP 4345 -1858
AKAP9 -1901 1042
AKT1 2261 1109
AKT1S1 3113 1894
AKT2 1896 5431
AP3B1 2856 3782
APBB1IP 4261 3821
APC 1724 1992
APH1A 904 -119
APH1B 3616 6785
ARRB1 1355 -1278
ARRB2 4301 2913
ATG7 2114 3847
AXIN1 -1113 -858
BAD 2600 4374
BAG4 3706 828
BCL2L1 1700 5970
BCL2L11 3454 5664
BCR 520 -1913
BIN2 3734 5390
BRAF 1497 -1526
BRAP 2154 -135
CALM1 -444 4502
CAMK2D -4472 -529
CAMK2G 891 6718
CASP9 4573 3202
CBL 3838 1012
CCNC -2845 4188
CDK8 1491 5795
CDKN1A 1908 2427
CDKN1B -1167 3367
CHUK 3252 1111
CLCN6 2285 1827
CNTRL -650 -1527
CPSF6 -2452 -1024
CREB1 -1515 1422
CREBBP 2992 892
CSK 3579 4890
CSNK1A1 3045 4452
CTBP1 1028 6471
CTNNB1 3708 5070
CUL1 -4198 -1192
CUX1 4623 4795
DERL2 23 -1578
DUSP10 -350 4700
DUSP16 -3527 28
DUSP6 -1141 -1943
DUSP7 -914 722
EP300 3773 4901
ERBB2 -2433 4160
ERLEC1 329 1240
ERLIN2 4478 786
ESR2 -3284 4784
ETV6 2899 -772
FBXW7 -468 6667
FGF9 -3672 997
FGFR1OP2 1131 2788
FIP1L1 -668 3099
FKBP1A 3296 1814
FLT3LG -4565 6677
FOXO1 -4379 3034
FOXO3 3778 5023
FRS2 -406 -882
FXR1 -952 5875
FYN -2007 2793
FZD5 4676 2664
FZD6 -3645 735
FZD8 -2438 2234
GAB2 4209 2390
GOLGA4 -1340 775
GOLGB1 -1527 5355
GRB2 4326 6241
GSK3A 3885 2534
GSK3B 2544 4908
GTF2F1 2368 558
GTF2F2 2169 5307
HBEGF 729 -1007
HDAC1 239 3287
HDAC10 852 4924
HDAC11 1885 6084
HDAC2 -2809 5864
HDAC3 1870 7116
HDAC4 4413 887
HDAC5 1171 3068
HDAC7 2654 -487
HHAT -1981 459
HRAS -2033 -823
HSP90AA1 -1535 6210
IQGAP1 3914 587
IRS1 -2377 4308
IRS2 3595 6152
JAK2 1521 6489
KANK1 -4183 4095
KAT2A -3982 1343
KAT2B 726 4028
KRAS 2127 3139
KSR1 4237 7147
LCK -4275 7246
LMNA 733 -1377
LRP5 -1475 -123
LRP6 -2999 1600
LRRFIP1 3283 5297
MAML1 3921 1442
MAML2 -2945 4627
MAML3 4280 3460
MAP2K1 3972 1533
MAP2K2 2576 6410
MAP3K11 4116 1270
MAPK1 4578 6099
MAPK3 3753 1978
MAPKAP1 1572 5908
MARK3 4359 3805
MDM2 2097 2095
MIB1 -2032 3187
MLST8 -375 2258
MPRIP -4356 2328
MTOR 616 3900
MYO18A 2325 -1785
NCBP1 -340 5859
NCBP2 -4320 4777
NCOR1 2997 -530
NCOR2 4583 -1609
NCSTN 4682 1224
NF1 2994 -328
NOTCH1 3629 6291
NR4A1 -990 1085
OS9 4446 -313
PAPSS1 4087 2272
PDPK1 3242 346
PEBP1 -4438 4325
PHB -2519 4542
PIK3AP1 4412 1373
PIK3CA 749 1470
PIK3CD 3357 6109
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R3 943 3645
PIM1 2662 1390
PLCG1 -4193 958
POLR2A 2854 4046
POLR2B -1272 5563
POLR2C -184 6356
POLR2D -2801 -614
POLR2E 1754 3712
POLR2F 1457 509
POLR2G 1427 1604
POLR2H -2461 6299
POLR2I -1497 5657
POLR2K -1891 3853
PPP1CB 2372 -340
PPP1CC 196 5379
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5A 3798 -230
PPP2R5B 3843 -286
PPP2R5C -2002 7074
PPP2R5D 2308 3470
PPP2R5E -960 1402
PRR5 -2760 -347
PSEN1 4153 4955
PSEN2 -2556 -162
PSENEN 2520 4980
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
PTEN 3653 4815
PTPN11 2272 5062
PTPN12 2791 -982
QKI 3215 2796
RAC1 4263 5541
RAC2 3032 4577
RAF1 3715 6573
RAP1A 2631 6569
RAP1B 2468 5968
RBPJ 3988 1033
RBX1 1356 5883
RHOG 4271 3664
RICTOR -2029 2833
RPS27A -4373 2589
RPS6KB2 1007 4805
SEL1L 2866 4058
SHC1 3650 3205
SHOC2 2120 34
SKP1 -2513 2680
SMAD2 2180 1865
SMAD3 -3344 -363
SMAD4 -1376 -1925
SND1 845 2977
SNW1 1166 2517
SOS1 -1111 -1986
SPRED1 1227 6065
SPRED2 4192 5462
SPRED3 745 5938
SPTBN1 -3485 3657
SRC -2558 -1476
STAT1 -4215 4970
STAT3 3745 4995
STAT5A 2844 -1545
STAT5B 3260 1495
STRN 2512 6485
SYVN1 1964 -846
TBL1XR1 1666 2633
TCF7L2 4350 1660
TGFA 4463 4632
TGFB1 1897 3769
TGFBR1 1701 -1264
TGFBR2 2002 2870
TLN1 3997 -983
TNKS 9 4477
TNKS2 1218 2960
TRIM24 69 -938
TRIP11 -1001 5856
TSC2 1480 3951
UBA52 -1313 -69
UBB 355 5059
UBC 2129 3220
VAV1 4015 5834
VCL 2144 3614
VCP 2829 1908
WDR48 -3026 2818
YES1 -1057 5198
YWHAB 1621 2152
ZC3HAV1 -3421 3768
ZFYVE9 -4386 3529
ZMYM2 2031 4446



Cytokine Signaling in Immune system

Cytokine Signaling in Immune system
metric value
setSize 424
pMANOVA 4.77e-09
p.adjustMANOVA 1.26e-07
s.dist 0.171
s.RNA 0.135
s.meth 0.105
p.RNA 2.48e-06
p.meth 0.000251




Top 20 genes
Gene RNA meth
SLA 4302 6986
PTPRJ 4090 7170
PRKCD 4562 6360
SOCS3 4385 6492
ITGB2 4401 6426
MAPK1 4578 6099
PTPN9 4514 6096
TRIM8 4311 6375
PTPN6 4161 6542
CRK 4125 6598
TNFRSF1B 3940 6870
GRB2 4326 6241
NOD2 3888 6610
ALOX5 4569 5386
EIF4G1 4196 5766
VAV1 4015 5834
TNFSF14 3206 7178
IL19 3115 7266
P4HB 3946 5718
IRS2 3595 6152

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1256 1467
ABCE1 -4561 6006
ABL2 1414 5308
ADAM17 4453 4155
ADAR 2571 3087
AIP -518 6684
AKT1 2261 1109
AKT2 1896 5431
ALOX5 4569 5386
APP 2164 6623
ARF1 4256 -1821
ARIH1 373 3751
ATF1 901 2989
B2M -2848 -9
BATF 1388 6679
BCL2 -2865 7022
BCL2L1 1700 5970
BCL2L11 3454 5664
BCL6 4635 3669
BIRC2 954 6626
BIRC3 -4544 4817
BIRC5 1558 1965
BRWD1 -2281 -349
BST2 -279 -1935
BTRC -1609 -923
CAMK2D -4472 -529
CAMK2G 891 6718
CANX 1159 3479
CAPZA1 3644 999
CASP1 1025 7031
CASP3 1520 5691
CBL 3838 1012
CCND1 -1449 1006
CCR1 3634 -1921
CD4 -2816 909
CD44 3510 4898
CDC42 3077 856
CDKN1A 1908 2427
CDKN1B -1167 3367
CEBPD 4221 -907
CFL1 3776 1646
CHUK 3252 1111
CISH -175 4928
CNN2 3453 -418
CREB1 -1515 1422
CRK 4125 6598
CRKL 1801 5167
CSF1 -64 356
CSK 3579 4890
CTF1 2341 543
CUL1 -4198 -1192
CUL5 -1067 344
CXCL2 1260 -1990
DDX58 -3149 185
DUSP3 3162 2260
DUSP4 -775 2494
DUSP6 -1141 -1943
DUSP7 -914 722
EDARADD -3847 6841
EGR1 -1531 1893
EIF2AK2 1924 683
EIF4A1 1909 881
EIF4A2 -4298 3601
EIF4A3 509 4598
EIF4E 577 6721
EIF4E2 1818 5876
EIF4E3 3665 -661
EIF4G1 4196 5766
EIF4G2 2337 6373
EIF4G3 4460 1034
FBXW11 1937 -1508
FLNB 2888 675
FLT3LG -4565 6677
FOS 989 5647
FOXO1 -4379 3034
FOXO3 3778 5023
FYN -2007 2793
GAB2 4209 2390
GATA3 -4560 6274
GBP3 -3751 89
GRAP2 -764 3631
GRB10 4673 3328
GRB2 4326 6241
GSDMD 139 -91
GSTO1 3474 3633
HERC5 -2754 -1038
HIF1A 3384 2448
HLA-A -2359 -1094
HLA-B -33 -730
HLA-C 1043 4449
HLA-E 727 5636
HLA-F -2137 2974
HLA-H -1015 4989
HMGB1 -2719 3222
HNRNPA2B1 1073 2721
HNRNPF 452 5857
HRAS -2033 -823
HSP90AA1 -1535 6210
HSP90B1 -644 2127
HSPA9 -4391 6551
ICAM1 388 2036
IFI30 4068 -1604
IFI35 1210 1292
IFI6 1729 5537
IFIT1 -1424 312
IFIT2 -3007 1477
IFIT3 -1745 6161
IFIT5 -2477 3745
IFITM1 -337 6985
IFNAR1 3726 1219
IFNAR2 3504 1115
IFNGR1 4264 4124
IFNGR2 4607 4231
IKBKB 612 -912
IL10RA -392 5518
IL10RB 4541 -1076
IL12A -3249 -1317
IL12RB1 -1989 6632
IL12RB2 -3666 -1861
IL15 -1219 3611
IL15RA -341 -1087
IL16 -774 5458
IL17C 1369 -1130
IL17RA 4554 130
IL17RC -1660 1939
IL18BP -758 -1640
IL18R1 2772 6744
IL19 3115 7266
IL1RAP 3352 -1122
IL21R -3121 2722
IL23A -4517 7078
IL27RA 1981 6659
IL2RA -3245 6868
IL2RB -4326 7237
IL32 -3938 7268
IL4R 4114 1274
IL6R 2714 5066
IL6ST -68 1708
INPP5D 3395 55
INPPL1 4354 588
IP6K2 -143 799
IRAK2 -1035 4686
IRAK3 4427 666
IRF1 -2321 5832
IRF2 3058 2365
IRF3 -2733 4241
IRF4 -3445 5941
IRF5 2465 -1651
IRF7 1413 3556
IRF9 626 4775
IRS1 -2377 4308
IRS2 3595 6152
ISG15 -1955 6541
ISG20 -2951 7060
ITGB2 4401 6426
JAK1 -2489 -283
JAK2 1521 6489
JUN 1097 1283
JUNB 2595 5018
KPNA1 -466 4423
KPNA2 -944 4421
KPNA3 -719 4400
KPNA4 1962 5000
KPNA5 -3957 1847
KPNB1 1929 1140
KRAS 2127 3139
LCK -4275 7246
LCP1 4071 4312
LGALS9 3873 -1462
LMNB1 4433 1051
LTA -4249 7256
LTB -4411 5586
MAP2K1 3972 1533
MAP2K3 4118 2411
MAP2K4 2808 4764
MAP2K6 4449 4792
MAP2K7 529 1764
MAP3K14 -3760 4221
MAP3K3 4156 3121
MAP3K7 1384 -147
MAP3K8 4618 3266
MAPK1 4578 6099
MAPK14 4535 2465
MAPK3 3753 1978
MAPK7 3913 -244
MAPK8 -3916 4554
MAPK9 -2113 157
MAPKAPK2 3308 3265
MAPKAPK3 4600 2896
MEF2A 3832 3013
MIF -2932 3355
MT2A 548 1186
MTAP -2661 2271
MUC1 1530 6715
MX1 -548 -1016
MX2 4410 1798
MYD88 4639 1945
NDC1 -4564 6482
NEDD4 3710 -1106
NFKB2 -1330 5251
NFKBIA 1880 6814
NFKBIB 2414 5574
NKIRAS1 -2478 348
NKIRAS2 4516 -1132
NOD1 -1381 -321
NOD2 3888 6610
NUP107 -3568 6301
NUP133 -2062 935
NUP153 96 4344
NUP155 -2910 3043
NUP160 -3599 1293
NUP188 -3388 2922
NUP205 -3151 1670
NUP210 -1503 690
NUP214 3964 4369
NUP35 -4376 -557
NUP37 -837 3398
NUP43 -3605 6346
NUP50 935 6706
NUP54 -2949 831
NUP62 -899 4609
NUP85 -1286 4518
NUP88 -4340 7084
NUP93 -2587 2006
NUP98 2030 -747
OAS1 677 -1507
OAS2 -1880 6618
OAS3 -1767 616
OASL 2421 5929
OSM 3158 1355
P4HB 3946 5718
PAK2 3401 283
PDCD4 -4493 4220
PDE12 -223 6083
PELI1 1650 1867
PELI2 2137 7035
PELI3 3441 -1123
PIAS1 2481 2845
PIK3CA 749 1470
PIK3CD 3357 6109
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R3 943 3645
PIM1 2662 1390
PIN1 214 4014
PITPNA 4148 3616
PLCG1 -4193 958
PML -294 4575
POM121 -48 4681
POM121C -623 2061
POU2F1 2852 3909
PPIA -2610 4555
PPM1B 2812 -144
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5D 2308 3470
PRKACA 4651 890
PRKCD 4562 6360
PRTN3 -4157 5621
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
PTK2B 4572 4529
PTPN1 4262 699
PTPN11 2272 5062
PTPN12 2791 -982
PTPN13 -2382 6850
PTPN18 4432 3436
PTPN2 3465 181
PTPN23 2552 5427
PTPN4 -3616 784
PTPN6 4161 6542
PTPN7 -233 2323
PTPN9 4514 6096
PTPRJ 4090 7170
RAE1 1714 2634
RALA -2555 2302
RANBP2 -405 5165
RAP1B 2468 5968
RAPGEF1 1750 6445
RBX1 1356 5883
RELA -73 4333
RELB 824 577
RNASEL 4378 3400
RNF7 2676 5841
RORA -4061 6933
RPLP0 -4084 4851
RPS27A -4373 2589
RPS6KA1 4529 -1859
RPS6KA2 1506 2117
RPS6KA5 -4174 1991
S1PR1 -1593 6791
SAMHD1 3411 6191
SEC13 2700 6211
SEH1L -4285 3577
SH2B1 -2131 1436
SH2B3 2353 3851
SHC1 3650 3205
SIGIRR -2791 6807
SKP1 -2513 2680
SLA 4302 6986
SLA2 -2507 4871
SMAD3 -3344 -363
SMARCA4 2865 6792
SNRPA1 -3010 1539
SOCS1 1609 4130
SOCS2 -1186 6479
SOCS3 4385 6492
SOCS5 108 466
SOD1 -3096 1838
SOD2 2609 6134
SOS1 -1111 -1986
SOS2 3749 3699
SP100 3525 2285
SQSTM1 -748 658
STAT1 -4215 4970
STAT2 -1314 5933
STAT3 3745 4995
STAT4 -3864 4203
STAT5A 2844 -1545
STAT5B 3260 1495
STAT6 3810 3854
STX1A 1229 4174
STX3 3994 2712
STX4 2492 1609
STXBP2 4615 -155
SUMO1 1392 3368
SYK 4033 431
TAB2 693 6401
TALDO1 4129 4422
TBK1 1669 599
TCP1 -1621 -448
TEC 3772 170
TGFB1 1897 3769
TNF -477 -526
TNFRSF12A 3482 681
TNFRSF1A 4465 -1548
TNFRSF1B 3940 6870
TNFRSF25 -4584 6989
TNFSF13 3950 -1364
TNFSF13B 2697 -384
TNFSF14 3206 7178
TNFSF9 999 447
TNIP2 2832 287
TOLLIP 3713 664
TP53 -4050 2709
TPR -1423 4616
TRAF2 -3119 5765
TRAF3 -3164 7209
TRAF6 1605 -71
TRIM14 2094 1982
TRIM2 -4169 646
TRIM21 1631 -1673
TRIM22 -557 2278
TRIM25 4522 446
TRIM26 1318 3540
TRIM35 -2674 1556
TRIM38 1611 4883
TRIM45 -2937 -1041
TRIM46 -3922 3136
TRIM5 2620 395
TRIM62 -159 3890
TRIM68 -2799 -539
TRIM8 4311 6375
TXLNA 1079 7007
TYK2 4387 4072
UBA3 2802 4052
UBA52 -1313 -69
UBA7 -1131 -1591
UBB 355 5059
UBC 2129 3220
UBE2D1 3526 2741
UBE2D2 -290 2134
UBE2D3 3214 3005
UBE2E1 -1112 2408
UBE2L6 -3276 1295
UBE2M 2658 2052
UBE2N -757 4834
UBE2V1 -446 2792
USP18 -542 -1013
VAMP2 -3788 -1239
VAV1 4015 5834
VEGFA 1946 87
VIM 4470 3780
VRK3 2567 2903
XAF1 -2052 -1464
YES1 -1057 5198
YWHAZ 1788 4294
ZEB1 -2893 5937



tRNA processing

tRNA processing
metric value
setSize 93
pMANOVA 4.78e-09
p.adjustMANOVA 1.26e-07
s.dist 0.377
s.RNA -0.368
s.meth 0.0824
p.RNA 9.37e-10
p.meth 0.171




Top 20 genes
Gene RNA meth
NUP88 -4340 7084
NDC1 -4564 6482
QTRT1 -4151 5789
NUP43 -3605 6346
ALKBH8 -4507 5003
NUP107 -3568 6301
TRMT61B -4100 5388
PUS7 -4089 5387
RPP25 -3799 5745
POP5 -3324 5989
METTL1 -4426 4406
LCMT2 -2552 6264
PUS1 -3238 4830
RPP38 -3246 4780
SEH1L -4285 3577
TRIT1 -2067 6755
CTU2 -1858 7026
TRMU -2043 6387
TSEN2 -3851 3306
THADA -2729 4244

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1256 1467
ADAT1 -469 5559
ADAT2 -3208 3497
ADAT3 1791 6334
ALKBH8 -4507 5003
C2orf49 -1930 2636
CDKAL1 -2311 4217
CLP1 1923 2378
CPSF1 -206 1083
CPSF4 -1537 1770
CTU1 1806 4162
CTU2 -1858 7026
DDX1 -2761 2193
DUS2 1005 710
ELAC2 -2081 275
FAM98B -2184 2205
GTPBP3 -3170 1640
LCMT2 -2552 6264
METTL1 -4426 4406
MTO1 -2888 396
NDC1 -4564 6482
NSUN2 436 2230
NSUN6 37 2767
NUP107 -3568 6301
NUP133 -2062 935
NUP153 96 4344
NUP155 -2910 3043
NUP160 -3599 1293
NUP188 -3388 2922
NUP205 -3151 1670
NUP210 -1503 690
NUP214 3964 4369
NUP35 -4376 -557
NUP37 -837 3398
NUP43 -3605 6346
NUP50 935 6706
NUP54 -2949 831
NUP62 -899 4609
NUP85 -1286 4518
NUP88 -4340 7084
NUP93 -2587 2006
NUP98 2030 -747
POM121 -48 4681
POM121C -623 2061
POP1 -2188 3613
POP4 26 1072
POP5 -3324 5989
POP7 -520 3070
PUS1 -3238 4830
PUS3 403 965
PUS7 -4089 5387
QTRT1 -4151 5789
RAE1 1714 2634
RAN -3671 1483
RANBP2 -405 5165
RPP14 -809 2236
RPP21 -1630 2599
RPP25 -3799 5745
RPP30 -3771 668
RPP38 -3246 4780
RPP40 -4559 570
RPPH1 4152 5012
RTCB -167 -1473
SEC13 2700 6211
SEH1L -4285 3577
THADA -2729 4244
THG1L -3084 2917
TP53RK -3369 2847
TPR -1423 4616
TPRKB -3323 3473
TRDMT1 -300 -401
TRIT1 -2067 6755
TRMT1 -2564 -744
TRMT10A 2447 1313
TRMT11 -4248 2032
TRMT112 -847 1929
TRMT12 -679 -1653
TRMT44 -1992 -1516
TRMT6 3036 3940
TRMT61A -2917 3423
TRMT61B -4100 5388
TRMU -2043 6387
TRNT1 -2149 4675
TSEN15 -3695 502
TSEN2 -3851 3306
TSEN34 3598 1820
TSEN54 -3253 591
TYW1 -4163 2393
TYW3 -4074 985
TYW5 500 3607
URM1 -628 3783
XPOT -2210 2981
ZBTB8OS 1375 266



Signaling by WNT

Signaling by WNT
metric value
setSize 174
pMANOVA 7.65e-09
p.adjustMANOVA 1.97e-07
s.dist 0.26
s.RNA 0.173
s.meth 0.194
p.RNA 8.78e-05
p.meth 1.14e-05




Top 20 genes
Gene RNA meth
CLTC 4062 7259
GNG5 4320 6512
FRAT1 4177 5692
RAC1 4263 5541
AGO1 3289 7140
KMT2D 3314 6495
TLE4 4122 5138
PSMD4 3943 5314
PSMA7 2849 6903
SMARCA4 2865 6792
CTNNB1 3708 5070
EP300 3773 4901
FRAT2 4335 4158
AP2S1 2943 6039
PSME3 3247 5232
PRKCB 3189 4964
SMURF1 2253 6934
PSMB6 2657 5819
AGO2 2116 7196
CSNK2A2 2634 5736

Click HERE to show all gene set members

All member genes
RNA meth
AGO1 3289 7140
AGO2 2116 7196
AGO3 899 3465
AKT1 2261 1109
AKT2 1896 5431
AP2A1 4643 -316
AP2M1 3281 3723
AP2S1 2943 6039
APC 1724 1992
ARRB2 4301 2913
ASH2L 3309 3075
AXIN1 -1113 -858
AXIN2 -3719 152
BCL9 -871 4909
BTRC -1609 -923
CALM1 -444 4502
CAV1 779 4592
CBY1 -3658 3274
CCDC88C -1770 6961
CDC73 2159 5719
CHD8 2824 -916
CLTA 2554 -546
CLTB 2902 -918
CLTC 4062 7259
CREBBP 2992 892
CSNK1A1 3045 4452
CSNK1E -2625 3000
CSNK1G2 1349 2563
CSNK2A2 2634 5736
CSNK2B 2032 4743
CTBP1 1028 6471
CTNNB1 3708 5070
CTNNBIP1 2340 1589
CUL1 -4198 -1192
CUL3 2149 -873
DAAM1 -1194 6127
DACT1 80 6080
DVL1 -1784 6368
DVL2 -2195 4884
DVL3 4159 161
EP300 3773 4901
FRAT1 4177 5692
FRAT2 4335 4158
FZD2 1758 2618
FZD3 -2350 6062
FZD5 4676 2664
FZD6 -3645 735
FZD7 -2239 2145
FZD8 -2438 2234
GNB1 4127 2799
GNB2 4050 1879
GNB4 2511 1335
GNB5 -1874 6256
GNG2 1099 6500
GNG3 1539 7142
GNG4 870 6856
GNG5 4320 6512
GNG7 -2307 -499
GNGT2 511 7120
GSK3B 2544 4908
HDAC1 239 3287
ITPR1 -1390 1789
ITPR2 2788 -44
ITPR3 -2430 2189
KAT5 1234 1952
KLHL12 4073 3615
KMT2D 3314 6495
KRAS 2127 3139
LEO1 -276 4252
LRP5 -1475 -123
LRP6 -2999 1600
MAP3K7 1384 -147
MEN1 -2073 1903
MOV10 -2344 -1882
NFATC1 -2446 6947
NLK 2036 -208
PARD6A -1805 4619
PDE6B -3818 1268
PFN1 3107 3814
PLCB2 2728 903
PLCB3 4631 -1268
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5A 3798 -230
PPP2R5B 3843 -286
PPP2R5C -2002 7074
PPP2R5D 2308 3470
PPP2R5E -960 1402
PPP3CA 1228 5980
PPP3CB 2123 4044
PPP3R1 1915 2945
PRKCA -898 6894
PRKCB 3189 4964
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
PYGO2 -3659 6530
RAC1 4263 5541
RAC2 3032 4577
RAC3 -984 827
RBBP5 -378 2829
RBX1 1356 5883
RHOA 3580 4033
RNF146 4444 1611
RPS27A -4373 2589
RUNX3 -2741 6760
RUVBL1 -3465 4751
RYK -4192 4958
SCRIB 962 -1418
SKP1 -2513 2680
SMARCA4 2865 6792
SMURF1 2253 6934
SMURF2 -2298 3523
SOX4 2349 4439
TCF7 -4594 6951
TCF7L2 4350 1660
TERT -1838 7281
TLE2 -4474 1969
TLE3 4587 3113
TLE4 4122 5138
TMED5 2850 1678
TNKS 9 4477
TNKS2 1218 2960
TNRC6A 119 5197
TNRC6B 110 7059
TRRAP -387 6328
UBA52 -1313 -69
UBB 355 5059
UBC 2129 3220
USP34 414 1573
USP8 2559 4109
VPS26A 2139 4070
VPS29 1235 688
VPS35 2381 -1447
WNT1 -2165 2325
WNT2B 1472 3566
XPO1 -1207 6847
YWHAZ 1788 4294
ZNRF3 -1990 3859



Signaling by NOTCH

Signaling by NOTCH
metric value
setSize 129
pMANOVA 9.6e-09
p.adjustMANOVA 2.42e-07
s.dist 0.3
s.RNA 0.241
s.meth 0.178
p.RNA 2.36e-06
p.meth 0.000518




Top 20 genes
Gene RNA meth
FURIN 4424 7181
APH1B 3616 6785
AGO1 3289 7140
NUMB 4658 5039
NOTCH1 3629 6291
TLE4 4122 5138
PSMD4 3943 5314
PSEN1 4153 4955
NOTCH4 4055 4962
B4GALT1 2813 7043
PSMA7 2849 6903
TACC3 3473 5485
ADAM17 4453 4155
EP300 3773 4901
SIRT6 2704 6645
DTX4 3444 5144
PSME3 3247 5232
PSMB6 2657 5819
AGO2 2116 7196
MAML3 4280 3460

Click HERE to show all gene set members

All member genes
RNA meth
ACTA2 -56 4718
ADAM10 3893 2760
ADAM17 4453 4155
AGO1 3289 7140
AGO2 2116 7196
AGO3 899 3465
AKT1 2261 1109
APH1A 904 -119
APH1B 3616 6785
ARRB1 1355 -1278
ARRB2 4301 2913
ATP2A1 1366 5724
ATP2A2 4104 -1550
ATP2A3 1257 1877
B4GALT1 2813 7043
CCNC -2845 4188
CCND1 -1449 1006
CDK8 1491 5795
CREB1 -1515 1422
CREBBP 2992 892
CUL1 -4198 -1192
DLGAP5 1614 -1160
DTX4 3444 5144
E2F1 2395 3145
E2F3 3565 2135
EP300 3773 4901
FBXW7 -468 6667
FURIN 4424 7181
HDAC1 239 3287
HDAC10 852 4924
HDAC11 1885 6084
HDAC2 -2809 5864
HDAC3 1870 7116
HDAC4 4413 887
HDAC5 1171 3068
HDAC7 2654 -487
HIF1A 3384 2448
IKZF1 -436 5424
ITCH 2375 4854
JUN 1097 1283
KAT2A -3982 1343
KAT2B 726 4028
LFNG 420 6685
MAML1 3921 1442
MAML2 -2945 4627
MAML3 4280 3460
MFNG -3205 6333
MIB1 -2032 3187
MOV10 -2344 -1882
NBEA -2688 7003
NCOR1 2997 -530
NCOR2 4583 -1609
NCSTN 4682 1224
NOTCH1 3629 6291
NOTCH4 4055 4962
NUMB 4658 5039
PLXND1 4289 -1845
POFUT1 2711 3622
PRKCI -2065 1662
PSEN1 4153 4955
PSEN2 -2556 -162
PSENEN 2520 4980
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSMF1 1458 7182
RAB6A 3874 3323
RBPJ 3988 1033
RBX1 1356 5883
RPS27A -4373 2589
RUNX1 4212 193
SEL1L 2866 4058
SIRT6 2704 6645
SKP1 -2513 2680
SMAD3 -3344 -363
SNW1 1166 2517
ST3GAL3 -2022 5837
ST3GAL4 4013 -1351
ST3GAL6 1125 6719
STAT1 -4215 4970
TACC3 3473 5485
TBL1XR1 1666 2633
TFDP1 3228 2953
TFDP2 -3622 -1478
TLE2 -4474 1969
TLE3 4587 3113
TLE4 4122 5138
TMED2 1834 5946
TNRC6A 119 5197
TNRC6B 110 7059
TP53 -4050 2709
UBA52 -1313 -69
UBB 355 5059
UBC 2129 3220
WWP2 4357 2916
YBX1 847 6425
YWHAZ 1788 4294



Leishmania infection

Leishmania infection
metric value
setSize 110
pMANOVA 1.89e-08
p.adjustMANOVA 4.66e-07
s.dist 0.331
s.RNA 0.33
s.meth -0.0208
p.RNA 2.46e-09
p.meth 0.707




Top 20 genes
Gene RNA meth
GGT1 4684 -1937
PYCARD 4218 -1820
C3AR1 4621 -1596
TXN 3518 -1735
FGR 4634 -1075
RHBDF2 3901 -1144
WASF1 4637 -830
ADCY4 3370 -1006
WIPF2 3237 -1018
NLRP3 3356 -847
ADCY7 2655 -981
PRKAR2A 2666 -874
VAV3 3114 -685
PRKAR1A 4198 -432
NCKAP1L 4625 -320
DPEP2 776 -1338
WIPF1 1102 -784
PTGER2 705 -850
WASF2 4371 -134
HRH2 4670 -109

Click HERE to show all gene set members

All member genes
RNA meth
ABI1 3566 3253
ABI2 -3506 -206
ABL1 2124 2469
ACTB 4254 5447
ACTG1 3711 1603
ACTR2 3331 3844
ACTR3 3319 5952
ADAM17 4453 4155
ADCY4 3370 -1006
ADCY7 2655 -981
ADCY9 -1063 5439
ADM 4679 5105
ADORA2A 1463 7186
ADRB2 -1168 2808
AHCYL1 2529 2692
ARPC1B 4355 1709
ARPC2 3393 2292
ARPC3 3253 3208
ARPC5 3952 2611
BAIAP2 -676 2757
BRK1 -951 3071
C3AR1 4621 -1596
CALM1 -444 4502
CASP1 1025 7031
CD247 -3828 6036
CDC42 3077 856
CREB1 -1515 1422
CRK 4125 6598
CYBA 3986 2019
CYFIP1 4146 256
CYFIP2 -275 6159
DPEP2 776 -1338
DVL1 -1784 6368
DVL2 -2195 4884
DVL3 4159 161
ELMO1 1879 939
ELMO2 3996 6110
ENTPD1 3467 7219
ENTPD5 -746 451
FGR 4634 -1075
FURIN 4424 7181
FYN -2007 2793
FZD7 -2239 2145
GGT1 4684 -1937
GIPR -3224 -792
GNAI2 4039 3218
GNAI3 3078 2359
GNAS 2061 -60
GNB1 4127 2799
GNB2 4050 1879
GNB4 2511 1335
GNB5 -1874 6256
GNG2 1099 6500
GNG3 1539 7142
GNG4 870 6856
GNG5 4320 6512
GNG7 -2307 -499
GNGT2 511 7120
GRB2 4326 6241
GSDMD 139 -91
HRH2 4670 -109
HSP90AB1 -4052 -1226
ITPR1 -1390 1789
ITPR2 2788 -44
ITPR3 -2430 2189
JUN 1097 1283
MAPK1 4578 6099
MAPK14 4535 2465
MAPK3 3753 1978
MAPK8 -3916 4554
MYH9 3495 6146
MYO9B 4389 6777
NCK1 -3937 1018
NCKAP1L 4625 -320
NCKIPSD -1401 667
NFKB2 -1330 5251
NLRP3 3356 -847
NOXA1 -1895 -376
P2RX4 2871 398
PLCG1 -4193 958
PLCG2 4027 2803
PLK2 206 5974
PRKACA 4651 890
PRKACB -4452 1712
PRKAR1A 4198 -432
PRKAR1B 1950 1230
PRKAR2A 2666 -874
PSTPIP1 4165 680
PTGER2 705 -850
PTGER4 -1413 5866
PTK2 147 -475
PYCARD 4218 -1820
RAC1 4263 5541
RELA -73 4333
RHBDF2 3901 -1144
SRC -2558 -1476
SUGT1 -1217 5005
SYK 4033 431
TXN 3518 -1735
TXNIP -1950 6154
VAV1 4015 5834
VAV2 975 4134
VAV3 3114 -685
VIPR1 -3085 5973
WASF1 4637 -830
WASF2 4371 -134
WASL 1150 4645
WIPF1 1102 -784
WIPF2 3237 -1018
YES1 -1057 5198



Cellular response to starvation

Cellular response to starvation
metric value
setSize 119
pMANOVA 3.28e-08
p.adjustMANOVA 7.93e-07
s.dist 0.32
s.RNA -0.293
s.meth 0.129
p.RNA 3.69e-08
p.meth 0.0151




Top 20 genes
Gene RNA meth
RPS3A -4434 7068
RPL7 -4400 7010
RPL3 -4497 6753
RPS2 -4297 6975
RPL34 -4236 6515
RPS12 -4108 6331
RPLP2 -4046 6423
RPL32 -4155 6000
RPL26 -3807 6409
RPS5 -3971 6072
RPS15A -3897 6112
RPL13A -4186 5523
RPS16 -3735 5981
RPS29 -3769 5602
RPL23A -4508 4560
RPL13 -3240 6189
RPLP0 -4084 4851
RPS3 -4130 4599
RPL37 -3340 5393
ITFG2 -3134 5711

Click HERE to show all gene set members

All member genes
RNA meth
ASNS -3290 -387
ATF3 -1642 2814
ATF4 -19 765
ATP6V0B 3770 5503
ATP6V0C 4469 2933
ATP6V0D1 4480 6936
ATP6V0E1 3116 1836
ATP6V0E2 -4219 -1327
ATP6V1A 3646 -1497
ATP6V1B2 3599 -1555
ATP6V1C1 3836 6759
ATP6V1D 3887 1096
ATP6V1E1 3016 4776
ATP6V1F 1310 -699
ATP6V1G2 -4032 3740
ATP6V1H 2526 2559
C12orf66 -2795 4504
CEBPB 4548 337
CEBPG 1441 1321
DDIT3 2252 5192
DEPDC5 3471 -1118
EIF2AK4 -601 2103
EIF2S1 -597 4745
EIF2S2 208 6254
FAU -1368 6877
FLCN 1483 6157
FNIP1 2599 5011
GCN1 -2187 -1761
ITFG2 -3134 5711
KPTN 2121 6304
LAMTOR1 3516 -1589
LAMTOR2 2924 -1342
LAMTOR3 1845 957
LAMTOR4 2085 7000
LAMTOR5 3327 -881
MIOS 707 -768
MLST8 -375 2258
MTOR 616 3900
NPRL2 -1931 7118
NPRL3 1499 2958
RHEB 1519 6311
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
RPTOR -402 5596
RRAGA 3399 6806
RRAGC 605 5284
RRAGD 3035 -1656
SEC13 2700 6211
SEH1L -4285 3577
SESN1 -2203 4661
SESN2 3762 -84
SLC38A9 1891 6117
SZT2 1771 441
TCIRG1 4550 1353
TRIB3 875 3767
UBA52 -1313 -69
WDR24 513 497
WDR59 -3604 3396



PIP3 activates AKT signaling

PIP3 activates AKT signaling
metric value
setSize 181
pMANOVA 6.42e-08
p.adjustMANOVA 1.52e-06
s.dist 0.24
s.RNA 0.177
s.meth 0.162
p.RNA 4.49e-05
p.meth 0.000178




Top 20 genes
Gene RNA meth
MAPK1 4578 6099
GRB2 4326 6241
RAC1 4263 5541
AGO1 3289 7140
VAV1 4015 5834
RRAGA 3399 6806
TRIM27 4077 5498
PHC2 4552 4887
IRS2 3595 6152
PSMD4 3943 5314
TGFA 4463 4632
PIK3CD 3357 6109
PSMA7 2849 6903
FOXO3 3778 5023
PTEN 3653 4815
PSME3 3247 5232
STRN 2512 6485
VAPA 3695 4246
RHOG 4271 3664
PSMB6 2657 5819

Click HERE to show all gene set members

All member genes
RNA meth
AGO1 3289 7140
AGO2 2116 7196
AGO3 899 3465
AKT1 2261 1109
AKT1S1 3113 1894
AKT2 1896 5431
ATN1 -352 3096
BAD 2600 4374
BMI1 -3597 -805
CASP9 4573 3202
CBX4 2670 278
CBX6 1804 3612
CBX8 927 4611
CDKN1A 1908 2427
CDKN1B -1167 3367
CHD3 -2622 6050
CHD4 107 640
CHUK 3252 1111
CNOT6L -3586 6262
CREB1 -1515 1422
CSNK2A2 2634 5736
CSNK2B 2032 4743
EED -2776 3088
EGR1 -1531 1893
ERBB2 -2433 4160
ESR2 -3284 4784
EZH2 -1432 2695
FGF9 -3672 997
FLT3LG -4565 6677
FOXO1 -4379 3034
FOXO3 3778 5023
FRS2 -406 -882
FYN -2007 2793
GAB2 4209 2390
GATAD2A 2436 189
GATAD2B 2076 5595
GRB2 4326 6241
GSK3A 3885 2534
GSK3B 2544 4908
HBEGF 729 -1007
HDAC1 239 3287
HDAC2 -2809 5864
HDAC3 1870 7116
HDAC5 1171 3068
HDAC7 2654 -487
IER3 2322 1545
IL1RAP 3352 -1122
INSR 3577 3558
IRS1 -2377 4308
IRS2 3595 6152
JUN 1097 1283
KDM1A -3041 5493
LAMTOR1 3516 -1589
LAMTOR2 2924 -1342
LAMTOR3 1845 957
LAMTOR4 2085 7000
LAMTOR5 3327 -881
LCK -4275 7246
MAF1 1423 6181
MAPK1 4578 6099
MAPK3 3753 1978
MAPKAP1 1572 5908
MBD3 -2339 6240
MDM2 2097 2095
MKRN1 2299 2197
MLST8 -375 2258
MOV10 -2344 -1882
MTA2 1016 5579
MTA3 -2954 5162
MTOR 616 3900
MYD88 4639 1945
NEDD4 3710 -1106
NR4A1 -990 1085
OTUD3 -2247 5747
PDPK1 3242 346
PHC1 -3734 -1213
PHC2 4552 4887
PHC3 -883 4977
PHLPP1 2814 5441
PHLPP2 -4321 6881
PIK3AP1 4412 1373
PIK3CA 749 1470
PIK3CD 3357 6109
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R3 943 3645
PIP4K2A 144 3045
PIP4K2B -2458 1071
PIP4K2C 386 223
PIP5K1A 2157 4436
PIP5K1C 2803 3895
PML -294 4575
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5A 3798 -230
PPP2R5B 3843 -286
PPP2R5C -2002 7074
PPP2R5D 2308 3470
PPP2R5E -960 1402
PRR5 -2760 -347
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
PTEN 3653 4815
PTPN11 2272 5062
RAC1 4263 5541
RAC2 3032 4577
RBBP4 -2172 4061
RCOR1 4251 -178
REST 517 1286
RHEB 1519 6311
RHOG 4271 3664
RICTOR -2029 2833
RING1 -1409 1003
RNF146 4444 1611
RNF2 95 2513
RPS27A -4373 2589
RPS6KB2 1007 4805
RPTOR -402 5596
RRAGA 3399 6806
RRAGC 605 5284
RRAGD 3035 -1656
SCMH1 -3931 95
SLC38A9 1891 6117
SRC -2558 -1476
STRN 2512 6485
STUB1 -996 2320
TGFA 4463 4632
THEM4 -4578 809
TNKS 9 4477
TNKS2 1218 2960
TNRC6A 119 5197
TNRC6B 110 7059
TP53 -4050 2709
TRAF6 1605 -71
TRIB3 875 3767
TRIM27 4077 5498
TSC2 1480 3951
UBA52 -1313 -69
UBB 355 5059
UBC 2129 3220
USP13 -515 2905
USP7 2170 3259
VAPA 3695 4246
VAV1 4015 5834
WWP2 4357 2916



Disease

Disease
metric value
setSize 929
pMANOVA 6.98e-08
p.adjustMANOVA 1.62e-06
s.dist 0.11
s.RNA 0.085
s.meth 0.0704
p.RNA 2.05e-05
p.meth 0.000422




Top 20 genes
Gene RNA meth
FURIN 4424 7181
KSR1 4237 7147
MYO9B 4389 6777
CLTC 4062 7259
GNG5 4320 6512
MAPK1 4578 6099
CRK 4125 6598
GRB2 4326 6241
TLR5 4577 5701
AP1B1 4407 5783
ST6GALNAC3 4509 5569
ENTPD1 3467 7219
DNAJC3 3801 6472
APH1B 3616 6785
RAF1 3715 6573
ELMO2 3996 6110
PHF21A 4672 5215
E2F2 4645 5231
ADM 4679 5105
RAC1 4263 5541

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1256 1467
ABCA1 2264 -82
ABCB6 -1071 -698
ABCD4 -1899 4719
ABI1 3566 3253
ABI2 -3506 -206
ABL1 2124 2469
ACACA 3683 1077
ACTB 4254 5447
ACTG1 3711 1603
ACTR2 3331 3844
ACTR3 3319 5952
ACY1 -2863 1746
ADAM10 3893 2760
ADAM17 4453 4155
ADAMTS10 -2206 -1433
ADAMTS13 56 -1294
ADAMTS17 -2718 -67
ADAMTS6 711 -624
ADAMTSL4 4581 1776
ADAMTSL5 -3158 -1286
ADCY4 3370 -1006
ADCY7 2655 -981
ADCY9 -1063 5439
ADM 4679 5105
ADORA2A 1463 7186
ADRB2 -1168 2808
AGGF1 2533 889
AGK -3770 492
AGRN -2240 2227
AGTRAP 4345 -1858
AHCY -933 5996
AHCYL1 2529 2692
AKAP9 -1901 1042
AKT1 2261 1109
AKT1S1 3113 1894
AKT2 1896 5431
ALG11 -1082 5298
ALG12 1978 1540
ALG14 1587 1973
ALG2 -635 6978
ALG3 -1751 3191
ALG6 -287 2858
ALG8 -2057 1673
ALG9 -2904 2495
ANAPC1 -4431 2990
ANAPC10 -653 -1326
ANAPC11 1335 3188
ANAPC15 3069 6483
ANAPC16 -3056 6729
ANAPC2 -1459 2865
ANAPC4 -998 -687
ANAPC5 -3133 5213
ANAPC7 182 1873
ANTXR2 1943 1887
AP1B1 4407 5783
AP1G1 2623 2214
AP1M1 3671 1777
AP1S3 -678 1942
AP2A1 4643 -316
AP2M1 3281 3723
AP2S1 2943 6039
AP3B1 2856 3782
APBB1IP 4261 3821
APC 1724 1992
APH1A 904 -119
APH1B 3616 6785
APP 2164 6623
ARF1 4256 -1821
ARID4A 650 2832
ARID4B 28 2402
ARPC1B 4355 1709
ARPC2 3393 2292
ARPC3 3253 3208
ARPC5 3952 2611
ARRB1 1355 -1278
ARRB2 4301 2913
ARSB 3918 -1528
ATG7 2114 3847
ATP1A1 1493 4101
ATP1A3 -864 1092
ATP1B1 -2422 6453
ATP1B3 2185 4129
ATP6V1H 2526 2559
AXIN1 -1113 -858
B2M -2848 -9
B3GALT6 -2263 7224
B3GAT3 -507 3020
B4GALT1 2813 7043
B4GALT7 -1893 4233
B4GAT1 -3049 -1493
BAD 2600 4374
BAG4 3706 828
BAIAP2 -676 2757
BANF1 -2509 4202
BARD1 1455 5972
BCL2L1 1700 5970
BCL2L11 3454 5664
BCR 520 -1913
BECN1 2010 4915
BIN2 3734 5390
BRAF 1497 -1526
BRAP 2154 -135
BRCA1 2494 1586
BRD4 4123 -1062
BRK1 -951 3071
BRMS1 1777 4574
BSG 3910 205
BTD -3966 -811
BTRC -1609 -923
C1GALT1 -482 2851
C1QBP -4004 5787
C3AR1 4621 -1596
CALM1 -444 4502
CALR 2787 5714
CAMK2D -4472 -529
CAMK2G 891 6718
CAMK4 -4589 2759
CANX 1159 3479
CAPN1 4234 1819
CAPN2 1843 453
CAPNS1 4001 5570
CASP1 1025 7031
CASP8 -1853 5448
CASP9 4573 3202
CAST 2166 2787
CBL 3838 1012
CBX1 459 1944
CCNC -2845 4188
CCND1 -1449 1006
CCND2 -3934 -1567
CCND3 4181 4156
CCNE1 -1399 5956
CCNE2 1238 5659
CCNH 723 1260
CCNK 2940 6593
CCNT1 -1482 1761
CD247 -3828 6036
CD320 -2327 5735
CD4 -2816 909
CDC16 -1567 3340
CDC23 -3790 1597
CDC25A 118 3280
CDC25B -4393 6646
CDC25C 2001 5507
CDC42 3077 856
CDK2 -1366 2965
CDK4 -4024 4919
CDK5 4265 3491
CDK5R1 469 7124
CDK6 -1861 562
CDK7 1419 4034
CDK8 1491 5795
CDK9 1936 3144
CDKN1A 1908 2427
CDKN1B -1167 3367
CDKN2A 21 3478
CEBPD 4221 -907
CHD3 -2622 6050
CHD4 107 640
CHMP1A 3135 2231
CHMP2A 4007 5362
CHMP2B 1081 1684
CHMP3 3197 3694
CHMP4A 1206 4138
CHMP4B 3974 5512
CHMP5 3912 4370
CHMP6 2834 2702
CHMP7 -3969 6064
CHST14 2461 -38
CHSY1 3269 -1145
CHUK 3252 1111
CLCN6 2285 1827
CLTA 2554 -546
CLTC 4062 7259
CNTRL -650 -1527
COMT 3163 -1096
CORO1A 2796 6642
CPSF4 -1537 1770
CPSF6 -2452 -1024
CRBN -2962 2140
CREB1 -1515 1422
CREBBP 2992 892
CRK 4125 6598
CSK 3579 4890
CSNK1A1 3045 4452
CTBP1 1028 6471
CTDP1 3527 1002
CTNNB1 3708 5070
CTNND1 868 -1709
CTSA 4396 2720
CTSL 4053 3028
CUL1 -4198 -1192
CUL5 -1067 344
CUX1 4623 4795
CXCR4 -442 -1435
CYBA 3986 2019
CYFIP1 4146 256
CYFIP2 -275 6159
CYP2R1 -942 3262
CYP2U1 -3212 3858
CYP4F22 1624 5603
DAD1 679 6510
DAG1 98 -94
DAXX -792 1574
DBP -3835 5710
DCXR -370 2344
DDX5 -2667 1804
DERL1 -2606 363
DERL2 23 -1578
DERL3 -1146 1587
DHDDS 3150 383
DNAJC3 3801 6472
DNMT1 -4316 4753
DNMT3A -747 -1253
DNMT3B 1281 3249
DOLK 296 4413
DPAGT1 -361 1961
DPEP2 776 -1338
DPM1 -489 5921
DPM2 1250 6197
DPM3 127 5732
DUSP10 -350 4700
DUSP16 -3527 28
DUSP6 -1141 -1943
DUSP7 -914 722
DUT -3438 1084
DVL1 -1784 6368
DVL2 -2195 4884
DVL3 4159 161
DYNC1H1 590 4434
DYNC1I2 2356 693
DYNC1LI1 3051 3242
DYNC1LI2 2757 -185
DYNLL1 521 5151
DYNLL2 -1889 -924
E2F1 2395 3145
E2F2 4645 5231
E2F3 3565 2135
EDEM2 4170 708
EED -2776 3088
EEF2 -2501 4196
EIF2AK2 1924 683
ELL 3009 1501
ELMO1 1879 939
ELMO2 3996 6110
ENO1 3359 -1624
ENTPD1 3467 7219
ENTPD5 -746 451
EP300 3773 4901
EPS15 2107 -516
ERBB2 -2433 4160
ERCC2 2316 1849
ERCC3 1189 1487
ERLEC1 329 1240
ERLIN1 4057 4339
ERLIN2 4478 786
ESR2 -3284 4784
ETV6 2899 -772
EXT1 3979 962
EXT2 1330 5514
EZH2 -1432 2695
F12 4667 1484
FADD 3278 -329
FAU -1368 6877
FBXW7 -468 6667
FDX1 -1596 3052
FDXR 881 1657
FEN1 -2603 6950
FGF9 -3672 997
FGFR1OP2 1131 2788
FGR 4634 -1075
FIP1L1 -668 3099
FKBP1A 3296 1814
FKBP4 -1907 2679
FLT3LG -4565 6677
FOXO1 -4379 3034
FOXO3 3778 5023
FRS2 -406 -882
FURIN 4424 7181
FUT8 -2035 6348
FXR1 -952 5875
FXYD7 -4177 -1998
FYN -2007 2793
FZD5 4676 2664
FZD6 -3645 735
FZD7 -2239 2145
FZD8 -2438 2234
FZR1 1357 2326
G6PC3 2330 -1289
GAA 3208 2768
GAB2 4209 2390
GALE 3084 -626
GALK1 4352 -745
GALNS 3403 3670
GALNT12 -3733 -1602
GALNT3 3280 -712
GALT -3372 4007
GANAB 1127 4411
GATAD2A 2436 189
GATAD2B 2076 5595
GCLC -2027 -1115
GCLM 2459 3701
GFPT1 -1511 -718
GGCX 3068 4622
GGT1 4684 -1937
GIPR -3224 -792
GLB1 4012 1828
GNAI2 4039 3218
GNAI3 3078 2359
GNAS 2061 -60
GNB1 4127 2799
GNB2 4050 1879
GNB4 2511 1335
GNB5 -1874 6256
GNE -1155 2902
GNG2 1099 6500
GNG3 1539 7142
GNG4 870 6856
GNG5 4320 6512
GNG7 -2307 -499
GNGT2 511 7120
GNS 4663 4429
GOLGA2 3585 -1361
GOLGA4 -1340 775
GOLGB1 -1527 5355
GPC2 -2379 7192
GPS2 896 6830
GRB2 4326 6241
GRSF1 -1089 4316
GSDMD 139 -91
GSK3A 3885 2534
GSK3B 2544 4908
GSS -592 4119
GTF2A1 -425 1479
GTF2A2 752 286
GTF2B 398 -1154
GTF2E2 2475 4885
GTF2F1 2368 558
GTF2F2 2169 5307
GTF2H3 -3711 5705
GTF2H4 -291 5240
GTF2H5 -620 3417
GUSB 4566 2338
GYG1 4408 -231
GYS1 3301 2472
HBEGF 729 -1007
HDAC1 239 3287
HDAC10 852 4924
HDAC11 1885 6084
HDAC2 -2809 5864
HDAC3 1870 7116
HDAC4 4413 887
HDAC5 1171 3068
HDAC7 2654 -487
HEXA -721 5238
HEXB 2779 2906
HGS 3544 4351
HGSNAT -268 3342
HHAT -1981 459
HK1 4409 4612
HLA-A -2359 -1094
HLCS -1120 1122
HMG20B 835 1259
HMGA1 -3089 2826
HMGB1 -2719 3222
HNRNPK 1903 3141
HRAS -2033 -823
HRH2 4670 -109
HSP90AA1 -1535 6210
HSP90AB1 -4052 -1226
HSPA1A 3554 -920
HYAL1 3090 -1974
IDH1 4668 3454
IDUA -2548 6735
IFNAR1 3726 1219
IFNAR2 3504 1115
IFNGR1 4264 4124
IFNGR2 4607 4231
IKBKB 612 -912
IL6R 2714 5066
IMPDH1 4624 2600
IMPDH2 -4586 250
IPO5 -4587 4875
IQGAP1 3914 587
IRS1 -2377 4308
IRS2 3595 6152
ISG15 -1955 6541
ITGA4 -3219 -394
ITPR1 -1390 1789
ITPR2 2788 -44
ITPR3 -2430 2189
JAK1 -2489 -283
JAK2 1521 6489
JUN 1097 1283
KANK1 -4183 4095
KAT2A -3982 1343
KAT2B 726 4028
KCNJ11 -2691 -1380
KDM1A -3041 5493
KHK -3145 1476
KPNA1 -466 4423
KPNA2 -944 4421
KPNA3 -719 4400
KPNA4 1962 5000
KPNA5 -3957 1847
KPNB1 1929 1140
KRAS 2127 3139
KSR1 4237 7147
LCK -4275 7246
LFNG 420 6685
LIG1 -4227 1086
LIG4 3161 4471
LMBRD1 641 1757
LMNA 733 -1377
LMNB1 4433 1051
LRP5 -1475 -123
LRP6 -2999 1600
LRRFIP1 3283 5297
MAML1 3921 1442
MAML2 -2945 4627
MAML3 4280 3460
MAN1B1 -248 6524
MAN2A1 -1534 2421
MAP2K1 3972 1533
MAP2K2 2576 6410
MAP2K3 4118 2411
MAP2K4 2808 4764
MAP2K6 4449 4792
MAP2K7 529 1764
MAP3K11 4116 1270
MAPK1 4578 6099
MAPK14 4535 2465
MAPK3 3753 1978
MAPK8 -3916 4554
MAPKAP1 1572 5908
MARK3 4359 3805
MBD3 -2339 6240
MCCC1 -3391 5912
MCCC2 -3547 6712
MDM2 2097 2095
MGAT1 2682 3827
MGAT2 1390 4676
MGAT4A -2915 3777
MGAT4B 2868 -1114
MGAT5 -2153 5133
MIB1 -2032 3187
MLST8 -375 2258
MMAA -2789 6866
MMAB -2919 1601
MMACHC -1823 -497
MMADHC 2309 5139
MNAT1 -2524 1516
MOGS -694 5808
MPDU1 3645 377
MPI -3722 1103
MPRIP -4356 2328
MSH2 -2948 5927
MSH3 555 3032
MSH6 -1051 6464
MTA2 1016 5579
MTA3 -2954 5162
MTOR 616 3900
MTR -3643 6467
MTRR 2365 4206
MUC1 1530 6715
MUC12 -670 4641
MUC5B 2214 -1745
MUTYH -3252 4906
MVB12A 2478 357
MYD88 4639 1945
MYH9 3495 6146
MYO18A 2325 -1785
MYO9B 4389 6777
NAGLU 592 -1230
NAPEPLD -2121 5683
NCBP1 -340 5859
NCBP2 -4320 4777
NCK1 -3937 1018
NCKAP1L 4625 -320
NCKIPSD -1401 667
NCOR1 2997 -530
NCOR2 4583 -1609
NCSTN 4682 1224
NDC1 -4564 6482
NEDD4L 3426 -1080
NEIL3 -600 2175
NELFA -1043 3055
NELFB 627 -649
NELFCD -1873 6416
NELFE 2357 1529
NEU1 4519 1899
NF1 2994 -328
NFKB2 -1330 5251
NFKBIA 1880 6814
NHLRC1 -99 -774
NLRP3 3356 -847
NMT1 3387 5713
NMT2 -4480 1226
NOTCH1 3629 6291
NOTCH4 4055 4962
NOXA1 -1895 -376
NR3C1 353 3509
NR4A1 -990 1085
NTHL1 -1467 73
NUP107 -3568 6301
NUP133 -2062 935
NUP153 96 4344
NUP155 -2910 3043
NUP160 -3599 1293
NUP188 -3388 2922
NUP205 -3151 1670
NUP210 -1503 690
NUP214 3964 4369
NUP35 -4376 -557
NUP37 -837 3398
NUP43 -3605 6346
NUP50 935 6706
NUP54 -2949 831
NUP62 -899 4609
NUP85 -1286 4518
NUP88 -4340 7084
NUP93 -2587 2006
NUP98 2030 -747
NUS1 2020 1360
OGG1 -876 -245
OS9 4446 -313
P2RX4 2871 398
PABPN1 -645 3061
PACS1 -1973 738
PAK2 3401 283
PAPSS1 4087 2272
PARP1 -3618 3582
PARP10 1311 6412
PARP14 -2087 -97
PARP16 -2515 631
PARP4 3862 5235
PARP6 -669 5464
PARP8 -1355 -1134
PARP9 2231 791
PC 3632 581
PCCB -2147 -1153
PDCD6IP 3530 5053
PDPK1 3242 346
PEBP1 -4438 4325
PGM1 2586 776
PHB -2519 4542
PHF21A 4672 5215
PIK3AP1 4412 1373
PIK3CA 749 1470
PIK3CD 3357 6109
PIK3R1 -3875 6993
PIK3R2 2266 3831
PIK3R3 943 3645
PIK3R4 -767 2170
PIM1 2662 1390
PLCG1 -4193 958
PLCG2 4027 2803
PLK2 206 5974
PML -294 4575
PMM2 -2108 5311
PMS2 -1590 5491
POLA2 -3386 -365
POLR2A 2854 4046
POLR2B -1272 5563
POLR2C -184 6356
POLR2D -2801 -614
POLR2E 1754 3712
POLR2F 1457 509
POLR2G 1427 1604
POLR2H -2461 6299
POLR2I -1497 5657
POLR2K -1891 3853
POM121 -48 4681
POM121C -623 2061
POMGNT1 -2976 3331
POMT1 -3092 3935
POMT2 -488 6243
PPIA -2610 4555
PPP1CB 2372 -340
PPP1CC 196 5379
PPP2CA 2390 2598
PPP2CB 2673 2771
PPP2R1B 39 6171
PPP2R5A 3798 -230
PPP2R5B 3843 -286
PPP2R5C -2002 7074
PPP2R5D 2308 3470
PPP2R5E -960 1402
PRDX1 1306 510
PRDX2 -1544 2503
PRIM1 -4049 3534
PRIM2 -2939 -307
PRKACA 4651 890
PRKACB -4452 1712
PRKAR1A 4198 -432
PRKAR1B 1950 1230
PRKAR2A 2666 -874
PRKCSH 2404 4698
PRR5 -2760 -347
PSEN1 4153 4955
PSEN2 -2556 -162
PSENEN 2520 4980
PSIP1 -4136 1734
PSMA1 1095 4759
PSMA2 -1044 5164
PSMA3 -2576 3586
PSMA5 -3128 3319
PSMA6 1790 6678
PSMA7 2849 6903
PSMB1 -1362 5410
PSMB10 -1548 6390
PSMB2 613 1518
PSMB3 2923 4306
PSMB5 3044 269
PSMB6 2657 5819
PSMB7 3139 4199
PSMB8 -158 5156
PSMB9 -3689 4469
PSMC1 1656 1413
PSMC3 319 736
PSMC4 221 3431
PSMC5 -1748 5095
PSMC6 1699 2356
PSMD1 3008 56
PSMD11 2819 3521
PSMD12 2396 3681
PSMD13 1294 561
PSMD14 327 6316
PSMD2 2990 3610
PSMD3 1475 5581
PSMD4 3943 5314
PSMD6 2617 2336
PSMD7 735 2079
PSMD8 1958 4666
PSMD9 3270 3375
PSME1 -3294 1614
PSME2 -3048 778
PSME3 3247 5232
PSME4 629 5910
PSMF1 1458 7182
PSTPIP1 4165 680
PTEN 3653 4815
PTGER2 705 -850
PTGER4 -1413 5866
PTGES3 -1846 4287
PTK2 147 -475
PTPN11 2272 5062
PTPN12 2791 -982
PYCARD 4218 -1820
QKI 3215 2796
RAB5A 2549 3958
RAB7A 3957 -124
RAC1 4263 5541
RAC2 3032 4577
RAE1 1714 2634
RAF1 3715 6573
RAN -3671 1483
RANBP1 -3474 6300
RANBP2 -405 5165
RANGAP1 -3743 3626
RAP1A 2631 6569
RAP1B 2468 5968
RB1 3804 1119
RBBP4 -2172 4061
RBPJ 3988 1033
RBX1 1356 5883
RCC1 -1421 3680
RCOR1 4251 -178
RELA -73 4333
REST 517 1286
RFT1 -79 5016
RHBDF2 3901 -1144
RHOG 4271 3664
RICTOR -2029 2833
RNF185 3021 5002
RNF213 -890 7097
RNF5 -1402 6758
RNGTT 1383 14
RNMT -3181 6871
ROCK1 3235 2732
RPL10A -3915 3590
RPL11 -4019 -495
RPL13 -3240 6189
RPL13A -4186 5523
RPL14 -4361 -798
RPL15 -3502 1424
RPL17 -4018 2296
RPL18 -3886 4479
RPL18A -3902 4255
RPL22 -4335 1020
RPL23 -3607 2729
RPL23A -4508 4560
RPL26 -3807 6409
RPL26L1 2084 3971
RPL27A -3974 1697
RPL28 -1479 4755
RPL29 -3761 2875
RPL3 -4497 6753
RPL31 -3844 -34
RPL32 -4155 6000
RPL34 -4236 6515
RPL35 -3511 4824
RPL36 -3137 2877
RPL36AL -2695 6352
RPL37 -3340 5393
RPL37A -2787 4982
RPL38 -3397 4431
RPL39L -604 5080
RPL4 -4269 1394
RPL41 -3175 821
RPL6 -4134 1979
RPL7 -4400 7010
RPL8 -2412 5094
RPL9 -2780 844
RPLP0 -4084 4851
RPLP1 -2370 1521
RPLP2 -4046 6423
RPN1 2547 6053
RPN2 3320 5501
RPS10 -3682 3925
RPS11 -3401 4225
RPS12 -4108 6331
RPS15 -2723 5623
RPS15A -3897 6112
RPS16 -3735 5981
RPS18 -3585 4163
RPS19 -3310 -362
RPS2 -4297 6975
RPS20 -4194 3461
RPS23 -4175 2986
RPS24 -2778 -518
RPS25 -4339 1797
RPS26 -410 5517
RPS27A -4373 2589
RPS27L -185 1405
RPS28 -3456 -1180
RPS29 -3769 5602
RPS3 -4130 4599
RPS3A -4434 7068
RPS5 -3971 6072
RPS6 -4362 361
RPS6KB2 1007 4805
RPS7 -4048 4408
RPS8 -3885 -79
RPS9 640 627
RPSA -2683 2072
S1PR1 -1593 6791
SAP18 528 5887
SAP30 3571 1163
SAP30L 2136 5024
SDC4 1974 2364
SEC13 2700 6211
SEH1L -4285 3577
SEL1L 2866 4058
SFPQ -1664 3947
SH3GL1 3692 6040
SHC1 3650 3205
SHOC2 2120 34
SIGMAR1 -1958 6976
SIN3A -3277 3819
SKP1 -2513 2680
SKP2 -683 1707
SLC11A2 135 2262
SLC12A6 3573 6142
SLC16A1 -540 5451
SLC17A5 1476 -1547
SLC20A2 -2019 6714
SLC22A5 2608 5708
SLC24A4 3476 -1623
SLC25A4 -3514 6752
SLC26A2 77 4122
SLC27A4 1577 -934
SLC29A3 2677 4866
SLC2A1 -1836 4076
SLC2A9 -9 -1831
SLC33A1 86 2774
SLC35A1 725 3966
SLC35A3 -2464 -802
SLC35C1 1722 5328
SLC35D1 -2053 4366
SLC37A4 -736 2820
SLC39A4 952 -1513
SLC3A2 2487 744
SLC5A5 -3833 487
SMAD2 2180 1865
SMAD3 -3344 -363
SMAD4 -1376 -1925
SND1 845 2977
SNF8 1860 5287
SNW1 1166 2517
SOD2 2609 6134
SOS1 -1111 -1986
SPON2 -2485 5932
SPRED1 1227 6065
SPRED2 4192 5462
SPRED3 745 5938
SPTBN1 -3485 3657
SRC -2558 -1476
SRD5A3 2451 2696
SSRP1 -4209 770
ST3GAL1 -2312 5845
ST3GAL2 4502 146
ST3GAL3 -2022 5837
ST3GAL4 4013 -1351
ST6GAL1 -3712 5784
ST6GALNAC3 4509 5569
ST6GALNAC4 1204 -713
STAM 314 6491
STAM2 2669 3301
STAT1 -4215 4970
STAT2 -1314 5933
STAT3 3745 4995
STAT5A 2844 -1545
STAT5B 3260 1495
STRN 2512 6485
STT3A 1022 5397
STX1A 1229 4174
STX1B -297 -1450
SUDS3 1064 1432
SUGT1 -1217 5005
SUMO1 1392 3368
SUPT16H -4404 4839
SUPT4H1 1139 5918
SUPT5H -1388 2020
SYK 4033 431
SYVN1 1964 -846
TAF10 3591 5288
TAF11 41 882
TAF12 3307 3413
TAF13 3249 3627
TAF15 -1869 4237
TAF2 1094 292
TAF3 -2114 1363
TAF4 497 554
TAF4B -3832 4706
TAF5 -2301 3430
TAF6 280 6843
TAF7 1115 455
TAF9 -1964 4396
TALDO1 4129 4422
TBK1 1669 599
TBL1XR1 1666 2633
TBXAS1 4570 -1853
TCEA1 -2578 4154
TCF7L2 4350 1660
TFDP1 3228 2953
TFDP2 -3622 -1478
TGFA 4463 4632
TGFB1 1897 3769
TGFBR1 1701 -1264
TGFBR2 2002 2870
TICAM1 3321 1060
TIRAP 3312 1661
TLN1 3997 -983
TLR1 3931 -1113
TLR2 4215 4128
TLR3 -3090 2949
TLR5 4577 5701
TLR6 3415 -1201
TLR9 -10 7204
TNKS 9 4477
TNKS2 1218 2960
TPMT 2416 -348
TPR -1423 4616
TPST1 4598 2033
TPST2 4044 2245
TRADD -3052 5248
TRAF2 -3119 5765
TRAF3 -3164 7209
TRIM24 69 -938
TRIM27 4077 5498
TRIM28 -3247 3596
TRIP11 -1001 5856
TSC2 1480 3951
TSG101 2874 -488
TUBB -611 6248
TXN 3518 -1735
TXNIP -1950 6154
TXNRD1 3831 -1402
TYK2 4387 4072
UBA52 -1313 -69
UBAP1 4101 5038
UBB 355 5059
UBC 2129 3220
UBE2C 1233 4535
UBE2D1 3526 2741
UBE2E1 -1112 2408
UBE2I -873 5796
UBE2S 1641 -706
UNC93B1 4207 4749
UVRAG -1978 5731
VAMP1 -1693 4536
VAMP2 -3788 -1239
VAV1 4015 5834
VAV2 975 4134
VAV3 3114 -685
VCL 2144 3614
VCP 2829 1908
VEGFA 1946 87
VHL 930 5209
VIPR1 -3085 5973
VPS25 3605 -962
VPS28 -269 6115
VPS33B 1969 3025
VPS36 -1723 1902
VPS37A 3267 3939
VPS37B 3202 -1611
VPS37C 4135 4035
VPS4A 66 3112
VTA1 1350 3950
WASF1 4637 -830
WASF2 4371 -134
WASL 1150 4645
WDR48 -3026 2818
WIPF1 1102 -784
WIPF2 3237 -1018
XPO1 -1207 6847
XRCC4 3026 5341
XRCC5 637 1327
XRCC6 -3489 3282
YES1 -1057 5198
YWHAB 1621 2152
YWHAE 3368 1288
ZBP1 -2358 7177
ZC3HAV1 -3421 3768
ZCRB1 -924 438
ZFYVE9 -4386 3529
ZMYM2 2031 4446



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.0   GGally_2.1.1    ggplot2_3.3.3   reshape2_1.4.4 
##  [5] beeswarm_0.3.1  gplots_3.1.1    gtools_3.8.2    tibble_3.1.0   
##  [9] dplyr_1.0.5     echarts4r_0.4.0 mitch_1.2.2    
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.6         rprojroot_2.0.2    assertthat_0.2.1   digest_0.6.27     
##  [5] utf8_1.2.1         mime_0.10          R6_2.5.0           plyr_1.8.6        
##  [9] evaluate_0.14      highr_0.8          pillar_1.5.1       rlang_0.4.10      
## [13] jquerylib_0.1.3    rmarkdown_2.7      labeling_0.4.2     desc_1.3.0        
## [17] stringr_1.4.0      htmlwidgets_1.5.3  munsell_0.5.0      shiny_1.6.0       
## [21] compiler_4.0.3     httpuv_1.5.5       xfun_0.22          pkgconfig_2.0.3   
## [25] htmltools_0.5.1.1  tidyselect_1.1.0   gridExtra_2.3      reshape_0.8.8     
## [29] fansi_0.4.2        crayon_1.4.1       withr_2.4.1        later_1.1.0.1     
## [33] MASS_7.3-53.1      bitops_1.0-6       grid_4.0.3         jsonlite_1.7.2    
## [37] xtable_1.8-4       gtable_0.3.0       lifecycle_1.0.0    DBI_1.1.1         
## [41] magrittr_2.0.1     scales_1.1.1       KernSmooth_2.23-18 stringi_1.5.3     
## [45] farver_2.1.0       promises_1.2.0.1   testthat_3.0.2     bslib_0.2.4       
## [49] ellipsis_0.3.1     generics_0.1.0     vctrs_0.3.6        RColorBrewer_1.1-2
## [53] tools_4.0.3        glue_1.4.2         purrr_0.3.4        parallel_4.0.3    
## [57] fastmap_1.1.0      yaml_2.2.1         colorspace_2.0-0   caTools_1.18.1    
## [61] knitr_1.31         sass_0.3.1

END of report