date generated: 2021-04-27

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##              RNA      meth
## A1BG  -3.3462109 0.9487855
## AAAS  -0.3078565 0.4334437
## AACS  -0.4896883 0.8690806
## AAGAB  1.1384144 0.5727567
## AAK1   0.5029925 0.7201373
## AAMDC -1.2878387 0.8935852

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 9321
duplicated_genes_present 0
num_profile_genes_in_sets 5605
num_profile_genes_not_in_sets 3716
profile_pearson_correl -0.04978
profile_spearman_correl -0.05494

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2484
num_genesets_excluded 1318
num_genesets_included 1166

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 95

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.RNA s.meth p.RNA p.meth
Eukaryotic Translation Elongation 70 3.26e-31 3.80e-28 0.8120 -0.8070 -0.089200 1.46e-31 0.1980
Peptide chain elongation 67 1.74e-29 1.01e-26 0.8050 -0.7990 -0.102000 1.04e-29 0.1510
Formation of a pool of free 40S subunits 76 4.76e-29 1.85e-26 0.7510 -0.7470 -0.081600 1.88e-29 0.2200
Selenocysteine synthesis 68 3.26e-27 9.49e-25 0.7690 -0.7660 -0.065000 7.64e-28 0.3550
Viral mRNA Translation 67 9.04e-27 2.11e-24 0.7670 -0.7630 -0.080700 3.03e-27 0.2540
Eukaryotic Translation Termination 70 1.73e-26 3.37e-24 0.7470 -0.7420 -0.080800 6.07e-27 0.2440
L13a-mediated translational silencing of Ceruloplasmin expression 85 5.91e-26 9.85e-24 0.6720 -0.6700 -0.053400 1.24e-26 0.3960
Selenoamino acid metabolism 76 1.74e-25 2.53e-23 0.7020 -0.6970 -0.083400 7.13e-26 0.2100
GTP hydrolysis and joining of the 60S ribosomal subunit 86 1.36e-24 1.76e-22 0.6510 -0.6490 -0.043100 2.30e-25 0.4900
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 72 1.45e-23 1.49e-21 0.6940 -0.6900 -0.073100 4.32e-24 0.2850
Cap-dependent Translation Initiation 93 1.54e-23 1.49e-21 0.6120 -0.6110 -0.040200 2.55e-24 0.5040
Eukaryotic Translation Initiation 93 1.54e-23 1.49e-21 0.6120 -0.6110 -0.040200 2.55e-24 0.5040
Response of EIF2AK4 (GCN2) to amino acid deficiency 76 5.39e-22 4.84e-20 0.6520 -0.6490 -0.062800 1.32e-22 0.3450
Regulation of expression of SLITs and ROBOs 122 1.22e-18 1.01e-16 0.4740 -0.4710 -0.049600 3.02e-19 0.3460
SRP-dependent cotranslational protein targeting to membrane 85 2.35e-18 1.83e-16 0.5600 -0.5530 -0.090600 1.36e-18 0.1500
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 86 8.86e-18 6.08e-16 0.5490 -0.5470 -0.053400 1.96e-18 0.3930
Nonsense-Mediated Decay (NMD) 86 8.86e-18 6.08e-16 0.5490 -0.5470 -0.053400 1.96e-18 0.3930
Cellular response to starvation 119 1.10e-17 7.11e-16 0.4690 -0.4690 -0.000553 1.11e-18 0.9920
Axon guidance 295 1.68e-17 1.03e-15 0.2980 -0.2970 -0.022700 2.94e-18 0.5060
Nervous system development 307 1.45e-16 8.43e-15 0.2840 -0.2830 -0.022900 2.61e-17 0.4930
Signaling by ROBO receptors 153 1.71e-15 9.52e-14 0.3860 -0.3860 -0.016500 2.26e-16 0.7270
Influenza Viral RNA Transcription and Replication 110 5.57e-15 2.95e-13 0.4460 -0.4450 -0.030700 8.96e-16 0.5800
Translation 234 3.99e-14 2.02e-12 0.2950 -0.2820 -0.087000 1.59e-13 0.0228
Cellular responses to external stimuli 457 1.78e-12 8.63e-11 0.2020 -0.2020 -0.013400 2.83e-13 0.6270
Cellular responses to stress 452 2.15e-12 1.00e-10 0.2030 -0.2020 -0.012400 3.31e-13 0.6560
Neutrophil degranulation 305 3.80e-12 1.70e-10 0.2420 -0.2400 -0.026400 8.35e-13 0.4330
Metabolism 1216 5.10e-12 2.20e-10 0.1300 -0.1250 0.034500 1.92e-12 0.0519
rRNA processing in the nucleus and cytosol 154 7.22e-12 3.01e-10 0.3320 -0.3260 -0.059800 3.23e-12 0.2030
Developmental Biology 451 1.06e-11 4.26e-10 0.1970 -0.1960 -0.018100 2.02e-12 0.5160
rRNA processing 159 1.56e-11 6.08e-10 0.3220 -0.3160 -0.061500 7.74e-12 0.1830
Influenza Infection 128 2.69e-11 1.01e-09 0.3560 -0.3550 -0.028900 4.75e-12 0.5740
Metabolism of amino acids and derivatives 219 3.52e-11 1.28e-09 0.2710 -0.2680 -0.041600 1.13e-11 0.2920
Infectious disease 530 5.03e-11 1.78e-09 0.1770 -0.1770 0.002000 5.98e-12 0.9380
Major pathway of rRNA processing in the nucleolus and cytosol 147 6.92e-11 2.37e-09 0.3240 -0.3170 -0.066400 3.79e-11 0.1670
Formation of the ternary complex, and subsequently, the 43S complex 40 1.69e-10 5.64e-09 0.6060 -0.5960 -0.109000 6.78e-11 0.2330
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 48 3.88e-10 1.26e-08 0.5450 -0.5390 -0.075100 1.03e-10 0.3690
Innate Immune System 616 5.23e-10 1.65e-08 0.1570 -0.1560 -0.006480 7.63e-11 0.7880
Translation initiation complex formation 47 7.71e-10 2.36e-08 0.5410 -0.5360 -0.076900 2.10e-10 0.3630
Ribosomal scanning and start codon recognition 47 1.75e-09 5.24e-08 0.5310 -0.5280 -0.061300 3.87e-10 0.4680
Disease 929 7.07e-09 2.06e-07 0.1220 -0.1220 0.005310 8.99e-10 0.7900
Interferon Signaling 142 2.14e-08 6.07e-07 0.2910 0.2890 -0.034400 3.00e-09 0.4810
Metabolism of carbohydrates 177 2.24e-07 6.21e-06 0.2450 -0.2360 0.065800 6.64e-08 0.1330
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 82 1.52e-06 4.13e-05 0.3290 -0.3270 -0.032800 3.15e-07 0.6080
Respiratory electron transport 81 1.72e-06 4.56e-05 0.3290 -0.3270 -0.040200 3.93e-07 0.5320
Interferon alpha/beta signaling 51 2.21e-06 5.72e-05 0.4170 0.4100 -0.076000 4.18e-07 0.3480
Cell Cycle 514 2.38e-06 6.02e-05 0.1340 0.1330 -0.019500 4.03e-07 0.4560
Gene expression (Transcription) 1005 2.74e-06 6.81e-05 0.0961 0.0927 0.025200 1.51e-06 0.1920
Antiviral mechanism by IFN-stimulated genes 77 4.23e-06 1.03e-04 0.3330 0.3210 -0.086700 1.16e-06 0.1890
Glycosaminoglycan metabolism 61 5.48e-06 1.30e-04 0.3730 -0.3330 0.168000 7.23e-06 0.0235
Homologous DNA Pairing and Strand Exchange 38 1.45e-05 3.38e-04 0.4380 0.4330 0.069000 3.92e-06 0.4630


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.RNA s.meth p.RNA p.meth
Eukaryotic Translation Elongation 70 3.26e-31 3.80e-28 0.81200 -8.07e-01 -0.089200 1.46e-31 0.19800
Peptide chain elongation 67 1.74e-29 1.01e-26 0.80500 -7.99e-01 -0.102000 1.04e-29 0.15100
Formation of a pool of free 40S subunits 76 4.76e-29 1.85e-26 0.75100 -7.47e-01 -0.081600 1.88e-29 0.22000
Selenocysteine synthesis 68 3.26e-27 9.49e-25 0.76900 -7.66e-01 -0.065000 7.64e-28 0.35500
Viral mRNA Translation 67 9.04e-27 2.11e-24 0.76700 -7.63e-01 -0.080700 3.03e-27 0.25400
Eukaryotic Translation Termination 70 1.73e-26 3.37e-24 0.74700 -7.42e-01 -0.080800 6.07e-27 0.24400
L13a-mediated translational silencing of Ceruloplasmin expression 85 5.91e-26 9.85e-24 0.67200 -6.70e-01 -0.053400 1.24e-26 0.39600
Selenoamino acid metabolism 76 1.74e-25 2.53e-23 0.70200 -6.97e-01 -0.083400 7.13e-26 0.21000
GTP hydrolysis and joining of the 60S ribosomal subunit 86 1.36e-24 1.76e-22 0.65100 -6.49e-01 -0.043100 2.30e-25 0.49000
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 72 1.45e-23 1.49e-21 0.69400 -6.90e-01 -0.073100 4.32e-24 0.28500
Cap-dependent Translation Initiation 93 1.54e-23 1.49e-21 0.61200 -6.11e-01 -0.040200 2.55e-24 0.50400
Eukaryotic Translation Initiation 93 1.54e-23 1.49e-21 0.61200 -6.11e-01 -0.040200 2.55e-24 0.50400
Response of EIF2AK4 (GCN2) to amino acid deficiency 76 5.39e-22 4.84e-20 0.65200 -6.49e-01 -0.062800 1.32e-22 0.34500
Regulation of expression of SLITs and ROBOs 122 1.22e-18 1.01e-16 0.47400 -4.71e-01 -0.049600 3.02e-19 0.34600
SRP-dependent cotranslational protein targeting to membrane 85 2.35e-18 1.83e-16 0.56000 -5.53e-01 -0.090600 1.36e-18 0.15000
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 86 8.86e-18 6.08e-16 0.54900 -5.47e-01 -0.053400 1.96e-18 0.39300
Nonsense-Mediated Decay (NMD) 86 8.86e-18 6.08e-16 0.54900 -5.47e-01 -0.053400 1.96e-18 0.39300
Cellular response to starvation 119 1.10e-17 7.11e-16 0.46900 -4.69e-01 -0.000553 1.11e-18 0.99200
Axon guidance 295 1.68e-17 1.03e-15 0.29800 -2.97e-01 -0.022700 2.94e-18 0.50600
Nervous system development 307 1.45e-16 8.43e-15 0.28400 -2.83e-01 -0.022900 2.61e-17 0.49300
Signaling by ROBO receptors 153 1.71e-15 9.52e-14 0.38600 -3.86e-01 -0.016500 2.26e-16 0.72700
Influenza Viral RNA Transcription and Replication 110 5.57e-15 2.95e-13 0.44600 -4.45e-01 -0.030700 8.96e-16 0.58000
Translation 234 3.99e-14 2.02e-12 0.29500 -2.82e-01 -0.087000 1.59e-13 0.02280
Cellular responses to external stimuli 457 1.78e-12 8.63e-11 0.20200 -2.02e-01 -0.013400 2.83e-13 0.62700
Cellular responses to stress 452 2.15e-12 1.00e-10 0.20300 -2.02e-01 -0.012400 3.31e-13 0.65600
Neutrophil degranulation 305 3.80e-12 1.70e-10 0.24200 -2.40e-01 -0.026400 8.35e-13 0.43300
Metabolism 1216 5.10e-12 2.20e-10 0.13000 -1.25e-01 0.034500 1.92e-12 0.05190
rRNA processing in the nucleus and cytosol 154 7.22e-12 3.01e-10 0.33200 -3.26e-01 -0.059800 3.23e-12 0.20300
Developmental Biology 451 1.06e-11 4.26e-10 0.19700 -1.96e-01 -0.018100 2.02e-12 0.51600
rRNA processing 159 1.56e-11 6.08e-10 0.32200 -3.16e-01 -0.061500 7.74e-12 0.18300
Influenza Infection 128 2.69e-11 1.01e-09 0.35600 -3.55e-01 -0.028900 4.75e-12 0.57400
Metabolism of amino acids and derivatives 219 3.52e-11 1.28e-09 0.27100 -2.68e-01 -0.041600 1.13e-11 0.29200
Infectious disease 530 5.03e-11 1.78e-09 0.17700 -1.77e-01 0.002000 5.98e-12 0.93800
Major pathway of rRNA processing in the nucleolus and cytosol 147 6.92e-11 2.37e-09 0.32400 -3.17e-01 -0.066400 3.79e-11 0.16700
Formation of the ternary complex, and subsequently, the 43S complex 40 1.69e-10 5.64e-09 0.60600 -5.96e-01 -0.109000 6.78e-11 0.23300
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 48 3.88e-10 1.26e-08 0.54500 -5.39e-01 -0.075100 1.03e-10 0.36900
Innate Immune System 616 5.23e-10 1.65e-08 0.15700 -1.56e-01 -0.006480 7.63e-11 0.78800
Translation initiation complex formation 47 7.71e-10 2.36e-08 0.54100 -5.36e-01 -0.076900 2.10e-10 0.36300
Ribosomal scanning and start codon recognition 47 1.75e-09 5.24e-08 0.53100 -5.28e-01 -0.061300 3.87e-10 0.46800
Disease 929 7.07e-09 2.06e-07 0.12200 -1.22e-01 0.005310 8.99e-10 0.79000
Interferon Signaling 142 2.14e-08 6.07e-07 0.29100 2.89e-01 -0.034400 3.00e-09 0.48100
Metabolism of carbohydrates 177 2.24e-07 6.21e-06 0.24500 -2.36e-01 0.065800 6.64e-08 0.13300
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 82 1.52e-06 4.13e-05 0.32900 -3.27e-01 -0.032800 3.15e-07 0.60800
Respiratory electron transport 81 1.72e-06 4.56e-05 0.32900 -3.27e-01 -0.040200 3.93e-07 0.53200
Interferon alpha/beta signaling 51 2.21e-06 5.72e-05 0.41700 4.10e-01 -0.076000 4.18e-07 0.34800
Cell Cycle 514 2.38e-06 6.02e-05 0.13400 1.33e-01 -0.019500 4.03e-07 0.45600
Gene expression (Transcription) 1005 2.74e-06 6.81e-05 0.09610 9.27e-02 0.025200 1.51e-06 0.19200
Antiviral mechanism by IFN-stimulated genes 77 4.23e-06 1.03e-04 0.33300 3.21e-01 -0.086700 1.16e-06 0.18900
Glycosaminoglycan metabolism 61 5.48e-06 1.30e-04 0.37300 -3.33e-01 0.168000 7.23e-06 0.02350
Homologous DNA Pairing and Strand Exchange 38 1.45e-05 3.38e-04 0.43800 4.33e-01 0.069000 3.92e-06 0.46300
Presynaptic phase of homologous DNA pairing and strand exchange 35 1.90e-05 4.34e-04 0.45300 4.52e-01 0.032600 3.73e-06 0.73900
Mitotic Prometaphase 154 3.05e-05 6.84e-04 0.21200 2.09e-01 0.032100 8.04e-06 0.49400
Cell Cycle Checkpoints 221 3.30e-05 7.26e-04 0.17900 1.78e-01 -0.011100 5.55e-06 0.77700
Resolution of Sister Chromatid Cohesion 90 4.15e-05 8.89e-04 0.27700 2.73e-01 -0.047300 8.17e-06 0.43900
PCP/CE pathway 71 4.19e-05 8.89e-04 0.31100 -3.06e-01 0.059400 8.71e-06 0.38800
RNA Polymerase II Transcription 894 5.34e-05 1.11e-03 0.08880 8.63e-02 0.021000 2.14e-05 0.30100
Platelet degranulation 49 1.07e-04 2.19e-03 0.35400 -3.53e-01 0.025700 1.91e-05 0.75600
Heparan sulfate/heparin (HS-GAG) metabolism 19 1.09e-04 2.20e-03 0.58100 -4.60e-01 0.354000 5.16e-04 0.00753
Response to elevated platelet cytosolic Ca2+ 53 1.15e-04 2.27e-03 0.34100 -3.37e-01 0.053200 2.26e-05 0.50400
Cell Cycle, Mitotic 416 1.20e-04 2.33e-03 0.12400 1.22e-01 -0.023300 2.55e-05 0.42200
Complex I biogenesis 43 1.31e-04 2.51e-03 0.36900 -3.63e-01 -0.066300 3.90e-05 0.45300
G2/M DNA damage checkpoint 52 1.56e-04 2.94e-03 0.33300 3.30e-01 0.046300 3.97e-05 0.56400
HDR through Single Strand Annealing (SSA) 34 1.99e-04 3.68e-03 0.40300 3.87e-01 0.111000 9.39e-05 0.26200
Cellular response to chemical stress 116 2.02e-04 3.68e-03 0.21900 -2.11e-01 -0.057700 8.92e-05 0.28500
The citric acid (TCA) cycle and respiratory electron transport 120 2.05e-04 3.68e-03 0.21700 -2.15e-01 -0.024900 4.86e-05 0.63900
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 81 3.04e-04 5.30e-03 0.26100 2.58e-01 -0.038500 6.16e-05 0.55000
Amplification of signal from the kinetochores 81 3.04e-04 5.30e-03 0.26100 2.58e-01 -0.038500 6.16e-05 0.55000
Platelet activation, signaling and aggregation 133 3.49e-04 5.98e-03 0.20400 -1.96e-01 0.054100 9.77e-05 0.28300
Signal Transduction 1294 3.98e-04 6.72e-03 0.06910 -6.76e-02 0.014000 9.16e-05 0.41700
Signaling by Interleukins 263 4.59e-04 7.65e-03 0.14100 -1.41e-01 -0.004610 9.39e-05 0.89800
Intracellular signaling by second messengers 206 4.70e-04 7.71e-03 0.16200 -1.47e-01 0.069300 3.03e-04 0.08850
ISG15 antiviral mechanism 70 4.88e-04 7.91e-03 0.27400 2.63e-01 -0.075900 1.43e-04 0.27300
Signaling by Receptor Tyrosine Kinases 284 5.14e-04 8.20e-03 0.13700 -1.31e-01 0.042300 1.71e-04 0.22400
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 23 5.54e-04 8.73e-03 0.46700 4.67e-01 -0.015300 1.08e-04 0.89900
EML4 and NUDC in mitotic spindle formation 85 6.01e-04 9.34e-03 0.24500 2.39e-01 -0.053000 1.45e-04 0.40000
Mitotic Spindle Checkpoint 96 6.69e-04 1.03e-02 0.22900 2.22e-01 -0.055000 1.74e-04 0.35300
Metabolism of RNA 535 7.84e-04 1.19e-02 0.09510 -8.60e-02 -0.040400 8.16e-04 0.11600
E2F mediated regulation of DNA replication 18 1.10e-03 1.65e-02 0.51200 4.69e-01 -0.206000 5.72e-04 0.13100
WNT5A-dependent internalization of FZD4 10 1.13e-03 1.66e-02 0.66700 -6.62e-01 -0.086400 2.91e-04 0.63600
PIP3 activates AKT signaling 181 1.14e-03 1.66e-02 0.16200 -1.54e-01 0.049200 3.72e-04 0.25600
Hemostasis 304 1.36e-03 1.96e-02 0.12200 -1.22e-01 0.005990 2.80e-04 0.85900
Detoxification of Reactive Oxygen Species 23 1.88e-03 2.67e-02 0.42700 -4.27e-01 0.017100 3.95e-04 0.88700
Resolution of D-loop Structures through Holliday Junction Intermediates 26 1.94e-03 2.72e-02 0.40600 3.91e-01 -0.108000 5.60e-04 0.34200
Diseases associated with glycosaminoglycan metabolism 15 1.96e-03 2.72e-02 0.54100 -3.60e-01 0.404000 1.59e-02 0.00678
Diseases of carbohydrate metabolism 22 1.98e-03 2.72e-02 0.43600 -4.35e-01 0.030800 4.19e-04 0.80300
Generic Transcription Pathway 802 2.91e-03 3.95e-02 0.07170 6.90e-02 0.019500 1.21e-03 0.36100
Resolution of D-Loop Structures 27 3.00e-03 4.02e-02 0.38400 3.69e-01 -0.107000 9.04e-04 0.33800
Mitochondrial translation elongation 83 3.10e-03 4.11e-02 0.21100 -1.81e-01 -0.108000 4.40e-03 0.09020
Leishmania infection 110 3.19e-03 4.18e-02 0.19200 -1.70e-01 0.089900 2.20e-03 0.10500
Metabolism of proteins 1263 3.49e-03 4.52e-02 0.05810 -5.71e-02 -0.010800 1.08e-03 0.53600
Transport of small molecules 342 3.64e-03 4.67e-02 0.10600 -1.05e-01 -0.014700 1.01e-03 0.64300
Pausing and recovery of Tat-mediated HIV elongation 25 3.79e-03 4.75e-02 0.38900 -3.82e-01 0.073300 9.38e-04 0.52600
Tat-mediated HIV elongation arrest and recovery 25 3.79e-03 4.75e-02 0.38900 -3.82e-01 0.073300 9.38e-04 0.52600
NS1 Mediated Effects on Host Pathways 38 3.90e-03 4.79e-02 0.31000 3.08e-01 0.035900 1.03e-03 0.70200
Processing of DNA double-strand break ends 54 3.90e-03 4.79e-02 0.25700 2.40e-01 0.091700 2.28e-03 0.24400
Late endosomal microautophagy 23 5.03e-03 6.07e-02 0.39100 -3.90e-01 -0.015200 1.20e-03 0.89900
Pexophagy 10 5.05e-03 6.07e-02 0.57800 -4.52e-01 -0.361000 1.34e-02 0.04840
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 14 5.36e-03 6.37e-02 0.51000 -4.60e-01 0.219000 2.89e-03 0.15600
PI3K/AKT Signaling in Cancer 50 5.56e-03 6.54e-02 0.26700 -2.57e-01 0.075000 1.72e-03 0.36000
The role of Nef in HIV-1 replication and disease pathogenesis 19 5.61e-03 6.54e-02 0.43500 -3.97e-01 0.179000 2.76e-03 0.17800
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 82 5.77e-03 6.66e-02 0.20200 1.94e-01 0.056500 2.41e-03 0.37800
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 5.85e-03 6.68e-02 0.50800 -5.00e-01 -0.091200 1.81e-03 0.56900
Cyclin A/B1/B2 associated events during G2/M transition 21 5.93e-03 6.71e-02 0.40800 3.97e-01 -0.097200 1.66e-03 0.44100
Glycogen storage diseases 10 6.04e-03 6.78e-02 0.58100 -5.81e-01 -0.029400 1.48e-03 0.87200
Autophagy 104 6.59e-03 7.32e-02 0.17900 -1.76e-01 -0.028000 1.94e-03 0.62300
Josephin domain DUBs 10 6.75e-03 7.43e-02 0.57100 -5.62e-01 -0.101000 2.08e-03 0.58200
Extracellular matrix organization 91 7.20e-03 7.84e-02 0.19200 -1.90e-01 0.026200 1.74e-03 0.66700
Chondroitin sulfate/dermatan sulfate metabolism 26 7.61e-03 8.22e-02 0.36300 -3.06e-01 0.196000 7.05e-03 0.08450
CDC6 association with the ORC:origin complex 10 8.08e-03 8.65e-02 0.57500 5.48e-01 -0.176000 2.70e-03 0.33600
Signaling by GPCR 200 8.40e-03 8.91e-02 0.12900 -1.25e-01 0.032500 2.46e-03 0.43100
DNA Double-Strand Break Repair 113 8.53e-03 8.96e-02 0.16600 1.62e-01 0.036400 2.95e-03 0.50600
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 8.68e-03 8.97e-02 0.25800 -2.44e-01 -0.085200 4.30e-03 0.31800
TCF dependent signaling in response to WNT 117 8.69e-03 8.97e-02 0.17000 -1.16e-01 0.124000 3.04e-02 0.02110
Gluconeogenesis 24 9.47e-03 9.69e-02 0.36200 -3.60e-01 0.038100 2.30e-03 0.74700
Activation of ATR in response to replication stress 33 9.59e-03 9.73e-02 0.30400 3.02e-01 0.038800 2.71e-03 0.70000
SUMOylation of intracellular receptors 19 9.68e-03 9.73e-02 0.41100 -1.44e-01 0.384000 2.76e-01 0.00374
Homology Directed Repair 88 1.02e-02 1.02e-01 0.18500 1.81e-01 0.039400 3.50e-03 0.52400
HIV elongation arrest and recovery 26 1.04e-02 1.02e-01 0.34500 -3.41e-01 0.056700 2.66e-03 0.61700
Pausing and recovery of HIV elongation 26 1.04e-02 1.02e-01 0.34500 -3.41e-01 0.056700 2.66e-03 0.61700
Plasma lipoprotein clearance 19 1.08e-02 1.05e-01 0.40200 -3.97e-01 0.058900 2.72e-03 0.65700
Plasma lipoprotein assembly, remodeling, and clearance 32 1.13e-02 1.09e-01 0.31100 -2.92e-01 0.109000 4.34e-03 0.28700
FLT3 Signaling 33 1.16e-02 1.11e-01 0.30000 -3.00e-01 0.001530 2.86e-03 0.98800
Interleukin-1 signaling 78 1.17e-02 1.11e-01 0.19200 -1.78e-01 -0.072500 6.84e-03 0.27000
Keratan sulfate/keratin metabolism 19 1.19e-02 1.12e-01 0.40500 -3.14e-01 0.256000 1.78e-02 0.05380
EGFR downregulation 20 1.26e-02 1.18e-01 0.38900 -3.60e-01 0.147000 5.29e-03 0.25600
SUMOylation of ubiquitinylation proteins 37 1.28e-02 1.19e-01 0.27600 2.67e-01 0.072900 5.04e-03 0.44300
GPCR downstream signalling 184 1.34e-02 1.23e-01 0.12800 -1.23e-01 0.035700 4.27e-03 0.40600
Mitochondrial translation termination 82 1.36e-02 1.24e-01 0.18300 -1.52e-01 -0.102000 1.80e-02 0.11000
Regulation of PTEN gene transcription 49 1.40e-02 1.26e-01 0.24200 -2.42e-01 0.019400 3.48e-03 0.81500
TRAF6 mediated IRF7 activation 15 1.41e-02 1.26e-01 0.42400 3.55e-01 0.232000 1.73e-02 0.11900
Interleukin-1 family signaling 98 1.46e-02 1.30e-01 0.16800 -1.59e-01 -0.051300 6.52e-03 0.38100
Cell surface interactions at the vascular wall 57 1.49e-02 1.31e-01 0.21600 -1.70e-01 -0.133000 2.63e-02 0.08230
Cytoprotection by HMOX1 94 1.50e-02 1.31e-01 0.16900 -1.50e-01 -0.078400 1.21e-02 0.19000
DNA Repair 239 1.51e-02 1.31e-01 0.10700 1.00e-01 0.039100 8.18e-03 0.30100
Beta-catenin independent WNT signaling 105 1.53e-02 1.31e-01 0.16700 -1.51e-01 0.071100 7.56e-03 0.21000
M Phase 291 1.53e-02 1.31e-01 0.10000 9.88e-02 -0.016500 4.07e-03 0.63100
Chaperone Mediated Autophagy 12 1.55e-02 1.32e-01 0.47200 -4.38e-01 -0.177000 8.69e-03 0.29000
Regulation of FZD by ubiquitination 11 1.61e-02 1.35e-01 0.51200 -4.40e-01 0.262000 1.15e-02 0.13300
HDR through Homologous Recombination (HRR) 58 1.61e-02 1.35e-01 0.21900 2.18e-01 -0.005730 4.07e-03 0.94000
PTEN Regulation 114 1.65e-02 1.37e-01 0.15600 -1.56e-01 0.010300 4.17e-03 0.85000
UCH proteinases 74 1.66e-02 1.38e-01 0.19200 -1.91e-01 -0.013500 4.51e-03 0.84100
ABC transporter disorders 56 1.68e-02 1.38e-01 0.22000 -2.19e-01 -0.018600 4.65e-03 0.81000
Lysosome Vesicle Biogenesis 25 1.69e-02 1.38e-01 0.33600 -3.16e-01 0.114000 6.30e-03 0.32600
Mitophagy 23 1.71e-02 1.38e-01 0.34500 -3.44e-01 0.026100 4.34e-03 0.82900
Disassembly of the destruction complex and recruitment of AXIN to the membrane 25 1.72e-02 1.38e-01 0.33800 -2.04e-01 0.270000 7.79e-02 0.01960
Mitochondrial translation initiation 83 1.75e-02 1.39e-01 0.17600 -1.46e-01 -0.098800 2.17e-02 0.12100
Mitochondrial translation 88 1.76e-02 1.39e-01 0.17100 -1.36e-01 -0.104000 2.83e-02 0.09160
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 66 1.78e-02 1.40e-01 0.20000 -1.94e-01 -0.047700 6.57e-03 0.50400
Regulation of TP53 Activity through Phosphorylation 76 1.83e-02 1.43e-01 0.18700 1.87e-01 0.013400 5.00e-03 0.84000
Regulation of RUNX1 Expression and Activity 15 1.87e-02 1.46e-01 0.43100 3.59e-01 -0.239000 1.62e-02 0.10900
Glycogen synthesis 11 1.89e-02 1.46e-01 0.49400 -4.89e-01 0.067800 5.00e-03 0.69700
RHO GTPases Activate NADPH Oxidases 14 1.95e-02 1.49e-01 0.43600 -4.32e-01 0.051600 5.10e-03 0.73800
Asymmetric localization of PCP proteins 51 1.96e-02 1.49e-01 0.22700 -2.27e-01 -0.003420 5.15e-03 0.96600
Assembly Of The HIV Virion 14 1.97e-02 1.49e-01 0.43500 -4.31e-01 0.061500 5.24e-03 0.69100
Signaling by WNT 174 1.99e-02 1.49e-01 0.12700 -7.33e-02 0.104000 9.72e-02 0.01920
Macroautophagy 95 2.01e-02 1.49e-01 0.16500 -1.62e-01 -0.029000 6.49e-03 0.62600
Nonhomologous End-Joining (NHEJ) 28 2.01e-02 1.49e-01 0.29900 2.79e-01 0.109000 1.07e-02 0.31900
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 15 2.05e-02 1.51e-01 0.41300 -3.62e-02 -0.412000 8.08e-01 0.00578
Abortive elongation of HIV-1 transcript in the absence of Tat 21 2.17e-02 1.59e-01 0.35700 -3.12e-01 0.172000 1.32e-02 0.17200
Cilium Assembly 147 2.18e-02 1.59e-01 0.13100 1.30e-01 0.020000 6.79e-03 0.67700
Transport of Ribonucleoproteins into the Host Nucleus 30 2.24e-02 1.62e-01 0.28700 2.77e-01 0.074900 8.79e-03 0.47800
PINK1-PRKN Mediated Mitophagy 18 2.25e-02 1.62e-01 0.37300 -3.71e-01 -0.034400 6.42e-03 0.80000
Constitutive Signaling by Aberrant PI3K in Cancer 26 2.28e-02 1.63e-01 0.31800 -2.93e-01 0.124000 9.86e-03 0.27500
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 71 2.35e-02 1.64e-01 0.18700 -1.87e-01 -0.016100 6.68e-03 0.81500
Toll Like Receptor 2 (TLR2) Cascade 71 2.35e-02 1.64e-01 0.18700 -1.87e-01 -0.016100 6.68e-03 0.81500
Toll Like Receptor TLR1:TLR2 Cascade 71 2.35e-02 1.64e-01 0.18700 -1.87e-01 -0.016100 6.68e-03 0.81500
Toll Like Receptor TLR6:TLR2 Cascade 71 2.35e-02 1.64e-01 0.18700 -1.87e-01 -0.016100 6.68e-03 0.81500
Signaling by NOTCH4 68 2.43e-02 1.68e-01 0.18700 -1.70e-01 -0.079300 1.57e-02 0.25900
Glycosphingolipid metabolism 27 2.44e-02 1.68e-01 0.30800 -2.92e-01 0.097400 8.67e-03 0.38100
Senescence-Associated Secretory Phenotype (SASP) 41 2.45e-02 1.68e-01 0.24600 -2.46e-01 -0.001250 6.54e-03 0.98900
EPH-ephrin mediated repulsion of cells 26 2.47e-02 1.69e-01 0.30900 -3.08e-01 0.025400 6.55e-03 0.82300
Transport of the SLBP Dependant Mature mRNA 34 2.51e-02 1.70e-01 0.26500 2.55e-01 0.071500 1.01e-02 0.47100
SUMOylation of DNA replication proteins 43 2.59e-02 1.74e-01 0.23300 2.03e-01 0.115000 2.17e-02 0.19400
Transport of the SLBP independent Mature mRNA 33 2.62e-02 1.75e-01 0.26800 2.63e-01 0.053700 8.98e-03 0.59400
RNA polymerase II transcribes snRNA genes 63 2.64e-02 1.75e-01 0.20000 1.87e-01 -0.072800 1.06e-02 0.31800
Cell-Cell communication 47 2.65e-02 1.75e-01 0.22200 -1.95e-01 -0.107000 2.11e-02 0.20600
RAF/MAP kinase cascade 156 2.76e-02 1.82e-01 0.12600 -1.25e-01 0.015000 7.51e-03 0.74800
Regulation of RUNX3 expression and activity 49 2.91e-02 1.90e-01 0.21400 -1.83e-01 -0.111000 2.66e-02 0.17800
Anchoring of the basal body to the plasma membrane 79 2.96e-02 1.92e-01 0.17200 1.71e-01 0.018000 8.78e-03 0.78300
RHO GTPases Activate Formins 100 2.97e-02 1.92e-01 0.15400 1.54e-01 -0.013600 8.04e-03 0.81500
Negative regulation of the PI3K/AKT network 53 3.02e-02 1.92e-01 0.21500 -1.90e-01 0.101000 1.68e-02 0.20600
MyD88 cascade initiated on plasma membrane 65 3.03e-02 1.92e-01 0.18800 -1.87e-01 -0.025500 9.40e-03 0.72300
Toll Like Receptor 10 (TLR10) Cascade 65 3.03e-02 1.92e-01 0.18800 -1.87e-01 -0.025500 9.40e-03 0.72300
Toll Like Receptor 5 (TLR5) Cascade 65 3.03e-02 1.92e-01 0.18800 -1.87e-01 -0.025500 9.40e-03 0.72300
Mitochondrial tRNA aminoacylation 18 3.08e-02 1.94e-01 0.36800 2.09e-01 -0.303000 1.25e-01 0.02600
Organelle biogenesis and maintenance 197 3.09e-02 1.94e-01 0.10800 1.02e-01 0.035000 1.43e-02 0.40000
Vpu mediated degradation of CD4 44 3.12e-02 1.95e-01 0.22600 -2.15e-01 -0.068800 1.37e-02 0.43100
SARS-CoV-2 Infection 56 3.14e-02 1.95e-01 0.20300 -2.02e-01 -0.014600 9.05e-03 0.85100
Immune System 1142 3.16e-02 1.95e-01 0.04730 -4.61e-02 -0.010500 1.14e-02 0.56500
Dectin-1 mediated noncanonical NF-kB signaling 52 3.20e-02 1.96e-01 0.20700 -1.93e-01 -0.074200 1.63e-02 0.35600
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 3.21e-02 1.96e-01 0.26400 -2.56e-01 -0.066500 1.24e-02 0.51600
Transport of Mature mRNAs Derived from Intronless Transcripts 41 3.24e-02 1.97e-01 0.23200 2.20e-01 0.074300 1.48e-02 0.41100
EPH-Ephrin signaling 56 3.42e-02 2.04e-01 0.20200 -2.01e-01 0.015000 9.38e-03 0.84600
MyD88 dependent cascade initiated on endosome 67 3.44e-02 2.04e-01 0.18100 -1.78e-01 -0.037900 1.22e-02 0.59300
Toll Like Receptor 7/8 (TLR7/8) Cascade 67 3.44e-02 2.04e-01 0.18100 -1.78e-01 -0.037900 1.22e-02 0.59300
Signaling by Hippo 12 3.45e-02 2.04e-01 0.42200 2.11e-01 0.365000 2.05e-01 0.02850
TNFR1-induced NFkappaB signaling pathway 19 3.45e-02 2.04e-01 0.35200 1.64e-01 -0.311000 2.15e-01 0.01910
Transport of Mature mRNA Derived from an Intronless Transcript 40 3.48e-02 2.05e-01 0.23400 2.26e-01 0.059700 1.36e-02 0.51400
ROS and RNS production in phagocytes 23 3.50e-02 2.05e-01 0.31100 -3.11e-01 -0.002970 9.77e-03 0.98000
Post-translational modification: synthesis of GPI-anchored proteins 28 3.53e-02 2.06e-01 0.28200 1.05e-02 0.281000 9.23e-01 0.01000
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 3.58e-02 2.08e-01 0.37800 -3.53e-01 -0.134000 1.80e-02 0.36900
Regulation of cholesterol biosynthesis by SREBP (SREBF) 46 3.60e-02 2.08e-01 0.21400 1.66e-01 0.135000 5.11e-02 0.11500
Neuronal System 130 3.62e-02 2.08e-01 0.13100 -1.31e-01 -0.004940 1.03e-02 0.92300
NEP/NS2 Interacts with the Cellular Export Machinery 30 3.66e-02 2.09e-01 0.26900 2.65e-01 0.044900 1.21e-02 0.67100
Condensation of Prometaphase Chromosomes 10 3.68e-02 2.09e-01 0.46900 4.69e-01 0.000924 1.03e-02 0.99600
Calnexin/calreticulin cycle 23 3.70e-02 2.10e-01 0.30100 -2.18e-01 -0.207000 7.04e-02 0.08560
MAPK1/MAPK3 signaling 161 3.74e-02 2.10e-01 0.11800 -1.17e-01 0.016000 1.06e-02 0.72800
Interferon gamma signaling 55 3.74e-02 2.10e-01 0.19700 1.87e-01 0.061400 1.67e-02 0.43100
Uptake and actions of bacterial toxins 19 3.79e-02 2.10e-01 0.33000 -2.47e-01 -0.218000 6.23e-02 0.09940
Nicotinamide salvaging 11 3.79e-02 2.10e-01 0.45300 4.26e-01 -0.155000 1.45e-02 0.37500
SUMOylation of DNA damage response and repair proteins 67 3.81e-02 2.10e-01 0.17800 1.67e-01 0.061500 1.86e-02 0.38500
Autodegradation of Cdh1 by Cdh1:APC/C 56 3.84e-02 2.11e-01 0.19300 -1.73e-01 -0.086200 2.56e-02 0.26500
HSF1-dependent transactivation 25 3.99e-02 2.18e-01 0.28600 -2.47e-01 -0.145000 3.29e-02 0.20900
Meiotic recombination 16 4.07e-02 2.22e-01 0.37100 3.51e-01 -0.120000 1.50e-02 0.40800
mRNA Splicing - Major Pathway 144 4.11e-02 2.23e-01 0.12300 -1.22e-01 0.010500 1.16e-02 0.82900
Cellular response to hypoxia 60 4.13e-02 2.23e-01 0.18500 -1.75e-01 -0.059800 1.89e-02 0.42400
NIK–>noncanonical NF-kB signaling 51 4.17e-02 2.24e-01 0.20000 -1.81e-01 -0.083900 2.52e-02 0.30100
Transcriptional Regulation by E2F6 29 4.19e-02 2.24e-01 0.27700 2.30e-01 -0.155000 3.24e-02 0.14900
Collagen formation 27 4.20e-02 2.24e-01 0.28500 -2.64e-01 0.108000 1.76e-02 0.33400
Elevation of cytosolic Ca2+ levels 10 4.23e-02 2.24e-01 0.44700 -2.80e-01 -0.348000 1.25e-01 0.05660
Cholesterol biosynthesis 20 4.25e-02 2.24e-01 0.31600 2.42e-01 0.203000 6.11e-02 0.11600
SARS-CoV Infections 115 4.27e-02 2.24e-01 0.13500 -1.35e-01 -0.010300 1.28e-02 0.84900
Glycogen metabolism 17 4.38e-02 2.29e-01 0.34300 -3.14e-01 -0.138000 2.49e-02 0.32600
Defective CFTR causes cystic fibrosis 52 4.39e-02 2.29e-01 0.19900 -1.96e-01 -0.030600 1.44e-02 0.70400
Metabolism of lipids 427 4.44e-02 2.29e-01 0.07160 -5.56e-03 0.071400 8.46e-01 0.01260
Degradation of DVL 48 4.45e-02 2.29e-01 0.20600 -2.04e-01 -0.032700 1.47e-02 0.69600
ER Quality Control Compartment (ERQC) 18 4.49e-02 2.31e-01 0.33000 -1.87e-01 -0.272000 1.70e-01 0.04550
Muscle contraction 64 4.56e-02 2.33e-01 0.17600 -8.76e-02 -0.152000 2.27e-01 0.03560
FCGR3A-mediated phagocytosis 43 4.66e-02 2.34e-01 0.22200 -2.07e-01 0.081600 1.90e-02 0.35500
Leishmania phagocytosis 43 4.66e-02 2.34e-01 0.22200 -2.07e-01 0.081600 1.90e-02 0.35500
Parasite infection 43 4.66e-02 2.34e-01 0.22200 -2.07e-01 0.081600 1.90e-02 0.35500
BMAL1:CLOCK,NPAS2 activates circadian gene expression 14 4.67e-02 2.34e-01 0.37200 2.74e-01 0.251000 7.59e-02 0.10400
Signaling by NTRKs 90 4.68e-02 2.34e-01 0.15300 -1.47e-01 0.044100 1.63e-02 0.47000
Spry regulation of FGF signaling 15 4.79e-02 2.38e-01 0.36000 -3.23e-01 -0.158000 3.04e-02 0.29000
Diseases of signal transduction by growth factor receptors and second messengers 265 4.85e-02 2.40e-01 0.08990 -8.53e-02 0.028400 1.78e-02 0.43000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 32 4.87e-02 2.41e-01 0.24500 -1.48e-01 -0.194000 1.47e-01 0.05710
Metabolism of steroids 81 4.91e-02 2.41e-01 0.15500 1.42e-01 0.061800 2.75e-02 0.33800
mRNA Splicing - Minor Pathway 44 4.98e-02 2.44e-01 0.21500 -2.13e-01 0.028700 1.46e-02 0.74200
Autodegradation of the E3 ubiquitin ligase COP1 43 5.06e-02 2.46e-01 0.21100 -1.97e-01 -0.075500 2.53e-02 0.39200
Downregulation of ERBB2 signaling 15 5.07e-02 2.46e-01 0.36400 -3.64e-01 -0.002820 1.48e-02 0.98500
Transport of Mature Transcript to Cytoplasm 63 5.11e-02 2.47e-01 0.17500 1.66e-01 0.056000 2.33e-02 0.44300
Ubiquitin-dependent degradation of Cyclin D 44 5.14e-02 2.47e-01 0.21000 -2.05e-01 -0.046000 1.89e-02 0.59800
Negative regulation of NOTCH4 signaling 48 5.30e-02 2.54e-01 0.19900 -1.91e-01 -0.057700 2.25e-02 0.49000
Hyaluronan metabolism 11 5.33e-02 2.54e-01 0.41800 -4.13e-01 -0.064000 1.78e-02 0.71300
Separation of Sister Chromatids 145 5.36e-02 2.54e-01 0.11900 1.08e-01 -0.049700 2.49e-02 0.30300
Deposition of new CENPA-containing nucleosomes at the centromere 20 5.38e-02 2.54e-01 0.31300 3.12e-01 -0.011600 1.56e-02 0.92900
Nucleosome assembly 20 5.38e-02 2.54e-01 0.31300 3.12e-01 -0.011600 1.56e-02 0.92900
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 5.56e-02 2.62e-01 0.21100 -2.00e-01 -0.067800 2.54e-02 0.44800
Mitotic Metaphase and Anaphase 194 5.60e-02 2.62e-01 0.10300 9.14e-02 -0.046900 2.91e-02 0.26300
p75 NTR receptor-mediated signalling 60 5.81e-02 2.71e-01 0.18100 -1.72e-01 0.057000 2.15e-02 0.44600
Ca2+ pathway 39 5.83e-02 2.71e-01 0.21500 1.28e-01 0.173000 1.67e-01 0.06240
Collagen biosynthesis and modifying enzymes 17 5.91e-02 2.74e-01 0.32900 -3.19e-01 -0.078900 2.28e-02 0.57300
TNFR2 non-canonical NF-kB pathway 67 5.99e-02 2.75e-01 0.16300 -1.19e-01 -0.112000 9.40e-02 0.11300
p75NTR signals via NF-kB 11 6.01e-02 2.75e-01 0.40900 -4.03e-01 -0.066700 2.06e-02 0.70200
SUMOylation of transcription factors 12 6.08e-02 2.75e-01 0.38400 2.33e-01 0.306000 1.63e-01 0.06690
ABC-family proteins mediated transport 72 6.11e-02 2.75e-01 0.15800 -1.47e-01 -0.057700 3.08e-02 0.39900
tRNA processing 93 6.11e-02 2.75e-01 0.14300 1.42e-01 -0.008420 1.80e-02 0.88900
Oxidative Stress Induced Senescence 54 6.11e-02 2.75e-01 0.18100 -1.41e-01 -0.114000 7.37e-02 0.14800
Clathrin-mediated endocytosis 90 6.13e-02 2.75e-01 0.14700 -1.36e-01 0.055100 2.57e-02 0.36700
Toll Like Receptor 9 (TLR9) Cascade 70 6.13e-02 2.75e-01 0.16200 -1.57e-01 -0.036100 2.30e-02 0.60200
SUMOylation of immune response proteins 10 6.17e-02 2.76e-01 0.44300 -3.29e-01 0.296000 7.13e-02 0.10600
MAP3K8 (TPL2)-dependent MAPK1/3 activation 14 6.22e-02 2.77e-01 0.35400 -2.57e-01 -0.243000 9.56e-02 0.11600
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 28 6.34e-02 2.77e-01 0.25400 2.50e-01 0.045500 2.23e-02 0.67700
Regulation of Glucokinase by Glucokinase Regulatory Protein 28 6.34e-02 2.77e-01 0.25400 2.50e-01 0.045500 2.23e-02 0.67700
Signaling by NOTCH 130 6.35e-02 2.77e-01 0.12000 -1.20e-01 0.010200 1.89e-02 0.84100
Degradation of GLI2 by the proteasome 50 6.39e-02 2.77e-01 0.18800 -1.76e-01 -0.067400 3.18e-02 0.41000
GLI3 is processed to GLI3R by the proteasome 50 6.39e-02 2.77e-01 0.18800 -1.76e-01 -0.067400 3.18e-02 0.41000
Negative regulation of FGFR1 signaling 17 6.43e-02 2.77e-01 0.32100 -2.85e-01 -0.148000 4.22e-02 0.29200
Negative regulation of FGFR2 signaling 17 6.43e-02 2.77e-01 0.32100 -2.85e-01 -0.148000 4.22e-02 0.29200
Negative regulation of FGFR3 signaling 17 6.43e-02 2.77e-01 0.32100 -2.85e-01 -0.148000 4.22e-02 0.29200
Negative regulation of FGFR4 signaling 17 6.43e-02 2.77e-01 0.32100 -2.85e-01 -0.148000 4.22e-02 0.29200
trans-Golgi Network Vesicle Budding 52 6.48e-02 2.78e-01 0.19200 -1.74e-01 0.079200 2.98e-02 0.32400
tRNA Aminoacylation 23 6.52e-02 2.78e-01 0.28900 1.82e-01 -0.225000 1.31e-01 0.06220
Nicotinate metabolism 19 6.56e-02 2.79e-01 0.31800 2.51e-01 -0.194000 5.80e-02 0.14300
G2/M Checkpoints 115 6.59e-02 2.79e-01 0.12600 1.25e-01 0.009730 2.08e-02 0.85700
MET promotes cell motility 13 6.69e-02 2.82e-01 0.36600 1.23e-01 0.344000 4.41e-01 0.03160
Selective autophagy 48 6.72e-02 2.82e-01 0.19400 -1.94e-01 -0.002050 2.04e-02 0.98000
TBC/RABGAPs 38 6.84e-02 2.82e-01 0.22200 -1.98e-01 0.102000 3.53e-02 0.27900
Peptide ligand-binding receptors 16 6.87e-02 2.82e-01 0.32700 -2.91e-01 -0.149000 4.40e-02 0.30400
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 44 6.89e-02 2.82e-01 0.19800 -1.88e-01 -0.062800 3.11e-02 0.47200
p53-Independent DNA Damage Response 44 6.89e-02 2.82e-01 0.19800 -1.88e-01 -0.062800 3.11e-02 0.47200
p53-Independent G1/S DNA damage checkpoint 44 6.89e-02 2.82e-01 0.19800 -1.88e-01 -0.062800 3.11e-02 0.47200
Sphingolipid de novo biosynthesis 23 6.91e-02 2.82e-01 0.27200 1.25e-01 0.242000 3.01e-01 0.04470
Meiosis 38 6.92e-02 2.82e-01 0.22200 1.97e-01 -0.102000 3.63e-02 0.27500
Interactions of Vpr with host cellular proteins 33 6.94e-02 2.82e-01 0.22800 2.13e-01 0.082000 3.46e-02 0.41500
Nuclear Pore Complex (NPC) Disassembly 34 6.96e-02 2.82e-01 0.22900 2.29e-01 -0.002220 2.11e-02 0.98200
Cargo recognition for clathrin-mediated endocytosis 65 6.98e-02 2.82e-01 0.16800 -1.62e-01 0.042100 2.38e-02 0.55800
Mitotic Prophase 73 7.01e-02 2.82e-01 0.16000 1.39e-01 -0.080100 4.11e-02 0.23800
RHOH GTPase cycle 28 7.02e-02 2.82e-01 0.25100 -6.07e-04 -0.251000 9.96e-01 0.02140
L1CAM interactions 40 7.02e-02 2.82e-01 0.21000 -2.10e-01 -0.007390 2.17e-02 0.93600
Activated NOTCH1 Transmits Signal to the Nucleus 19 7.03e-02 2.82e-01 0.29900 -2.78e-01 -0.110000 3.58e-02 0.40500
Regulation of mRNA stability by proteins that bind AU-rich elements 77 7.10e-02 2.83e-01 0.14900 -1.42e-01 -0.046400 3.17e-02 0.48300
Sphingolipid metabolism 50 7.12e-02 2.83e-01 0.19300 -1.01e-01 0.164000 2.19e-01 0.04470
Transmission across Chemical Synapses 96 7.22e-02 2.86e-01 0.13800 -1.32e-01 0.039500 2.60e-02 0.50500
Budding and maturation of HIV virion 24 7.28e-02 2.88e-01 0.26800 -2.66e-01 -0.033000 2.42e-02 0.78000
TNF signaling 37 7.38e-02 2.90e-01 0.21900 4.86e-02 -0.214000 6.09e-01 0.02450
Mitotic Anaphase 193 7.38e-02 2.90e-01 0.09800 8.67e-02 -0.045600 3.89e-02 0.27800
Peptide hormone metabolism 26 7.40e-02 2.90e-01 0.25400 2.35e-01 0.094600 3.80e-02 0.40400
Interactions of Rev with host cellular proteins 34 7.43e-02 2.90e-01 0.22200 2.08e-01 0.076400 3.57e-02 0.44200
Mitochondrial protein import 47 7.47e-02 2.90e-01 0.19300 -1.92e-01 0.019000 2.29e-02 0.82200
Fcgamma receptor (FCGR) dependent phagocytosis 63 7.51e-02 2.91e-01 0.17000 -1.47e-01 0.084400 4.34e-02 0.24700
Signaling by EGFR 36 7.61e-02 2.94e-01 0.22000 -2.18e-01 0.029800 2.37e-02 0.75700
tRNA processing in the nucleus 55 7.70e-02 2.96e-01 0.17600 1.76e-01 0.004440 2.40e-02 0.95500
Export of Viral Ribonucleoproteins from Nucleus 31 7.72e-02 2.96e-01 0.23300 2.32e-01 0.024900 2.55e-02 0.81100
Cellular Senescence 105 7.74e-02 2.96e-01 0.12700 -1.25e-01 -0.023000 2.78e-02 0.68500
Membrane Trafficking 436 7.89e-02 3.00e-01 0.06550 -5.22e-02 0.039600 6.54e-02 0.16200
Fc epsilon receptor (FCERI) signaling 109 7.93e-02 3.00e-01 0.12700 -1.23e-01 0.029000 2.67e-02 0.60200
Prefoldin mediated transfer of substrate to CCT/TriC 17 7.94e-02 3.00e-01 0.31900 -3.09e-01 0.081200 2.76e-02 0.56200
Translation of structural proteins 26 7.97e-02 3.00e-01 0.25000 -2.35e-01 -0.085700 3.81e-02 0.45000
Downstream TCR signaling 72 7.98e-02 3.00e-01 0.15100 -1.45e-01 -0.041800 3.34e-02 0.54100
Transport of Mature mRNA derived from an Intron-Containing Transcript 54 8.04e-02 3.01e-01 0.17500 1.71e-01 0.034300 2.96e-02 0.66300
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 47 8.05e-02 3.01e-01 0.19300 -1.79e-01 0.072200 3.41e-02 0.39200
Hh mutants are degraded by ERAD 47 8.09e-02 3.01e-01 0.18700 -1.82e-01 -0.041700 3.10e-02 0.62100
RAB geranylgeranylation 39 8.11e-02 3.01e-01 0.20900 3.00e-02 -0.207000 7.46e-01 0.02560
Nuclear import of Rev protein 31 8.19e-02 3.02e-01 0.22900 2.19e-01 0.065600 3.50e-02 0.52800
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 8.19e-02 3.02e-01 0.36300 -2.91e-01 -0.216000 8.05e-02 0.19400
AURKA Activation by TPX2 58 8.26e-02 3.04e-01 0.16600 1.44e-01 0.082200 5.85e-02 0.28000
Signaling by NOTCH3 30 8.40e-02 3.07e-01 0.23100 -2.16e-01 -0.081000 4.09e-02 0.44300
PLC beta mediated events 29 8.43e-02 3.07e-01 0.24500 -1.61e-01 0.185000 1.33e-01 0.08540
rRNA modification in the nucleus and cytosol 47 8.43e-02 3.07e-01 0.18300 -1.18e-01 -0.139000 1.62e-01 0.09890
Membrane binding and targetting of GAG proteins 12 8.54e-02 3.09e-01 0.36700 -3.65e-01 -0.043200 2.88e-02 0.79600
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 8.54e-02 3.09e-01 0.36700 -3.65e-01 -0.043200 2.88e-02 0.79600
G-protein mediated events 32 8.56e-02 3.09e-01 0.23300 -1.70e-01 0.159000 9.70e-02 0.11900
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 53 8.58e-02 3.09e-01 0.17300 -1.59e-01 -0.067700 4.59e-02 0.39500
Response of Mtb to phagocytosis 20 8.65e-02 3.10e-01 0.27900 -2.37e-01 -0.147000 6.66e-02 0.25600
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 37 8.72e-02 3.12e-01 0.20800 -2.78e-02 -0.206000 7.70e-01 0.03000
ER-Phagosome pathway 69 8.82e-02 3.13e-01 0.15000 -1.33e-01 -0.070000 5.69e-02 0.31600
Signaling by Nuclear Receptors 147 8.82e-02 3.13e-01 0.10500 -1.04e-01 -0.012300 2.99e-02 0.79700
Vesicle-mediated transport 442 8.83e-02 3.13e-01 0.06370 -4.83e-02 0.041400 8.59e-02 0.14100
Hh mutants abrogate ligand secretion 48 8.85e-02 3.13e-01 0.18200 -1.80e-01 -0.027500 3.11e-02 0.74200
Neurotransmitter receptors and postsynaptic signal transmission 74 8.94e-02 3.13e-01 0.15000 -1.42e-01 0.049200 3.49e-02 0.46600
Loss of Nlp from mitotic centrosomes 55 8.95e-02 3.13e-01 0.16700 1.34e-01 0.099100 8.53e-02 0.20400
Loss of proteins required for interphase microtubule organization from the centrosome 55 8.95e-02 3.13e-01 0.16700 1.34e-01 0.099100 8.53e-02 0.20400
Hyaluronan uptake and degradation 10 9.00e-02 3.13e-01 0.39600 -3.89e-01 -0.076400 3.33e-02 0.67600
Nuclear Receptor transcription pathway 26 9.02e-02 3.13e-01 0.25200 -2.42e-01 0.070200 3.27e-02 0.53600
Synthesis of IP3 and IP4 in the cytosol 15 9.04e-02 3.13e-01 0.33600 -2.42e-01 0.233000 1.05e-01 0.11800
Activation of NF-kappaB in B cells 57 9.15e-02 3.13e-01 0.16500 -1.58e-01 -0.048200 3.97e-02 0.53000
Anti-inflammatory response favouring Leishmania parasite infection 51 9.15e-02 3.13e-01 0.18200 -1.54e-01 0.096200 5.75e-02 0.23500
Leishmania parasite growth and survival 51 9.15e-02 3.13e-01 0.18200 -1.54e-01 0.096200 5.75e-02 0.23500
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 19 9.16e-02 3.13e-01 0.29500 -2.76e-01 0.103000 3.72e-02 0.43800
Processing of Capped Intronless Pre-mRNA 21 9.19e-02 3.13e-01 0.27600 -1.22e-02 0.276000 9.23e-01 0.02890
Signaling by TGF-beta Receptor Complex 63 9.20e-02 3.13e-01 0.15500 -1.05e-01 -0.114000 1.52e-01 0.11700
mRNA Splicing 151 9.21e-02 3.13e-01 0.10300 -1.03e-01 0.003630 2.90e-02 0.93900
ROS sensing by NFE2L2 48 9.24e-02 3.13e-01 0.18300 -1.82e-01 0.007550 2.91e-02 0.92800
Condensation of Prophase Chromosomes 11 9.26e-02 3.13e-01 0.38900 3.28e-01 -0.209000 5.94e-02 0.23000
Signaling by VEGF 73 9.27e-02 3.13e-01 0.14900 -1.46e-01 0.030600 3.11e-02 0.65200
SHC1 events in ERBB2 signaling 11 9.47e-02 3.18e-01 0.38200 -7.11e-02 0.375000 6.83e-01 0.03140
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 26 9.54e-02 3.18e-01 0.24000 -1.02e-01 -0.218000 3.69e-01 0.05480
Inhibition of replication initiation of damaged DNA by RB1/E2F1 10 9.56e-02 3.18e-01 0.40600 3.16e-01 -0.255000 8.37e-02 0.16200
Smooth Muscle Contraction 19 9.57e-02 3.18e-01 0.28400 -2.79e-01 -0.054300 3.56e-02 0.68200
Recruitment of NuMA to mitotic centrosomes 63 9.57e-02 3.18e-01 0.15400 8.80e-02 0.126000 2.28e-01 0.08360
Regulation of actin dynamics for phagocytic cup formation 45 9.63e-02 3.19e-01 0.19000 -1.76e-01 0.073100 4.19e-02 0.39700
DNA Damage Recognition in GG-NER 35 9.78e-02 3.23e-01 0.20600 -1.83e-01 -0.094400 6.12e-02 0.33400
TCR signaling 88 9.87e-02 3.24e-01 0.13000 -1.15e-01 -0.060300 6.26e-02 0.33000
Signaling by Insulin receptor 42 9.88e-02 3.24e-01 0.19100 -1.89e-01 -0.021500 3.39e-02 0.81000
Inhibition of DNA recombination at telomere 16 9.95e-02 3.26e-01 0.31700 -2.88e-01 0.131000 4.62e-02 0.36400
NOD1/2 Signaling Pathway 23 1.00e-01 3.27e-01 0.26600 1.91e-01 -0.184000 1.12e-01 0.12700
Cobalamin (Cbl, vitamin B12) transport and metabolism 10 1.00e-01 3.27e-01 0.40000 3.62e-01 -0.168000 4.73e-02 0.35800
Reproduction 43 1.01e-01 3.28e-01 0.19400 1.56e-01 -0.115000 7.68e-02 0.19300
Hedgehog ‘off’ state 75 1.02e-01 3.31e-01 0.14000 -1.28e-01 -0.055700 5.50e-02 0.40500
Signaling by NOTCH1 51 1.02e-01 3.31e-01 0.17300 -1.73e-01 -0.003080 3.32e-02 0.97000
Nuclear Envelope Breakdown 49 1.03e-01 3.31e-01 0.17500 1.72e-01 0.029900 3.75e-02 0.71800
GPCR ligand binding 68 1.03e-01 3.32e-01 0.15000 -1.50e-01 0.003670 3.32e-02 0.95800
MAPK family signaling cascades 186 1.05e-01 3.33e-01 0.09230 -8.71e-02 0.030600 4.16e-02 0.47500
Vpr-mediated nuclear import of PICs 32 1.05e-01 3.33e-01 0.21400 2.05e-01 0.059700 4.47e-02 0.55900
mTORC1-mediated signalling 22 1.05e-01 3.33e-01 0.26600 -2.53e-01 0.079000 3.97e-02 0.52200
Keratan sulfate biosynthesis 15 1.05e-01 3.33e-01 0.32400 -2.86e-01 0.151000 5.50e-02 0.31100
COPI-dependent Golgi-to-ER retrograde traffic 64 1.06e-01 3.35e-01 0.15000 6.17e-02 0.137000 3.94e-01 0.05880
Mitotic G2-G2/M phases 155 1.06e-01 3.35e-01 0.09870 9.86e-02 0.003420 3.49e-02 0.94200
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.06e-01 3.35e-01 0.33200 1.14e-01 -0.312000 4.59e-01 0.04330
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 27 1.07e-01 3.36e-01 0.24200 1.75e-01 -0.166000 1.15e-01 0.13500
Class A/1 (Rhodopsin-like receptors) 41 1.08e-01 3.37e-01 0.18900 -1.85e-01 -0.037300 4.08e-02 0.68000
Signaling by NTRK1 (TRKA) 82 1.08e-01 3.38e-01 0.13700 -1.33e-01 0.033700 3.85e-02 0.59900
Uptake and function of anthrax toxins 10 1.09e-01 3.38e-01 0.37600 -3.43e-01 -0.155000 6.03e-02 0.39700
Vif-mediated degradation of APOBEC3G 43 1.09e-01 3.38e-01 0.18300 -1.79e-01 -0.039400 4.23e-02 0.65500
Polo-like kinase mediated events 14 1.09e-01 3.38e-01 0.32600 3.25e-01 -0.028900 3.54e-02 0.85100
Insulin processing 17 1.09e-01 3.39e-01 0.29200 2.88e-01 0.048700 4.01e-02 0.72800
G alpha (q) signalling events 73 1.11e-01 3.41e-01 0.14600 -1.25e-01 0.074300 6.51e-02 0.27300
Degradation of AXIN 47 1.11e-01 3.41e-01 0.17400 -1.69e-01 -0.043700 4.56e-02 0.60500
Signaling by BRAF and RAF fusions 42 1.11e-01 3.41e-01 0.18400 -6.47e-02 -0.172000 4.69e-01 0.05450
Regulation of TNFR1 signaling 30 1.12e-01 3.41e-01 0.22200 2.65e-02 -0.221000 8.02e-01 0.03660
RHOA GTPase cycle 91 1.12e-01 3.41e-01 0.12700 -1.27e-01 0.004230 3.66e-02 0.94500
Glycerophospholipid biosynthesis 71 1.13e-01 3.41e-01 0.14800 -9.76e-02 0.111000 1.56e-01 0.10800
Centrosome maturation 64 1.13e-01 3.41e-01 0.14700 9.63e-02 0.111000 1.83e-01 0.12500
Recruitment of mitotic centrosome proteins and complexes 64 1.13e-01 3.41e-01 0.14700 9.63e-02 0.111000 1.83e-01 0.12500
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 19 1.13e-01 3.41e-01 0.28300 -2.41e-01 0.149000 6.91e-02 0.26100
Neurodegenerative Diseases 19 1.13e-01 3.41e-01 0.28300 -2.41e-01 0.149000 6.91e-02 0.26100
Regulated Necrosis 42 1.14e-01 3.42e-01 0.18800 4.63e-02 -0.183000 6.04e-01 0.04080
NRIF signals cell death from the nucleus 14 1.14e-01 3.42e-01 0.31600 -2.96e-01 -0.108000 5.49e-02 0.48300
Metabolism of polyamines 48 1.16e-01 3.48e-01 0.17000 -1.57e-01 -0.064500 6.02e-02 0.44000
Hedgehog ligand biogenesis 51 1.17e-01 3.49e-01 0.16800 -1.67e-01 -0.003200 3.88e-02 0.96800
SCF-beta-TrCP mediated degradation of Emi1 47 1.17e-01 3.49e-01 0.17100 -1.59e-01 -0.065000 6.05e-02 0.44200
SUMOylation of SUMOylation proteins 32 1.18e-01 3.49e-01 0.20800 2.00e-01 0.058500 5.07e-02 0.56700
CLEC7A (Dectin-1) signaling 84 1.19e-01 3.51e-01 0.13100 -1.31e-01 0.003050 3.91e-02 0.96200
GAB1 signalosome 10 1.19e-01 3.51e-01 0.38100 -3.69e-01 0.096700 4.34e-02 0.59700
Mitochondrial Fatty Acid Beta-Oxidation 25 1.19e-01 3.51e-01 0.24100 -5.88e-02 0.234000 6.11e-01 0.04300
APC/C:Cdc20 mediated degradation of Securin 58 1.20e-01 3.51e-01 0.15300 -1.41e-01 -0.060200 6.33e-02 0.42900
Metabolism of non-coding RNA 47 1.21e-01 3.53e-01 0.17500 1.73e-01 -0.028200 4.09e-02 0.73800
snRNP Assembly 47 1.21e-01 3.53e-01 0.17500 1.73e-01 -0.028200 4.09e-02 0.73800
Amyloid fiber formation 24 1.21e-01 3.53e-01 0.23800 -2.28e-01 -0.070100 5.35e-02 0.55300
Negative regulation of FLT3 13 1.22e-01 3.54e-01 0.33200 -3.26e-01 0.062400 4.21e-02 0.69700
Activation of gene expression by SREBF (SREBP) 34 1.22e-01 3.55e-01 0.19900 8.95e-02 0.177000 3.67e-01 0.07380
Nuclear signaling by ERBB4 16 1.25e-01 3.61e-01 0.28600 -1.95e-01 -0.210000 1.77e-01 0.14700
Heme signaling 24 1.25e-01 3.61e-01 0.23900 2.49e-02 0.238000 8.33e-01 0.04400
Rev-mediated nuclear export of HIV RNA 33 1.25e-01 3.61e-01 0.20200 1.91e-01 0.064800 5.80e-02 0.52000
Deactivation of the beta-catenin transactivating complex 28 1.27e-01 3.65e-01 0.22800 -1.71e-01 0.150000 1.17e-01 0.16900
Caspase activation via extrinsic apoptotic signalling pathway 15 1.31e-01 3.76e-01 0.30700 2.70e-01 -0.147000 7.03e-02 0.32500
NOTCH1 Intracellular Domain Regulates Transcription 37 1.31e-01 3.76e-01 0.19200 -1.92e-01 0.015100 4.40e-02 0.87400
Regulation of ornithine decarboxylase (ODC) 43 1.32e-01 3.76e-01 0.17700 -1.77e-01 -0.002330 4.46e-02 0.97900
Antigen processing-Cross presentation 77 1.34e-01 3.80e-01 0.13000 -1.18e-01 -0.053600 7.38e-02 0.41700
Interleukin-17 signaling 53 1.35e-01 3.84e-01 0.15600 -1.46e-01 -0.054400 6.60e-02 0.49400
Amino acids regulate mTORC1 43 1.36e-01 3.84e-01 0.18100 -1.44e-01 0.109000 1.02e-01 0.21700
Regulation of HMOX1 expression and activity 55 1.36e-01 3.85e-01 0.15400 -1.50e-01 -0.032700 5.41e-02 0.67600
Maturation of nucleoprotein 10 1.37e-01 3.85e-01 0.37300 3.20e-01 -0.192000 8.00e-02 0.29300
Stabilization of p53 48 1.37e-01 3.86e-01 0.16200 -1.29e-01 -0.097800 1.22e-01 0.24200
VEGFA-VEGFR2 Pathway 71 1.38e-01 3.88e-01 0.13900 -1.33e-01 0.037100 5.23e-02 0.59000
Regulation of PTEN stability and activity 56 1.39e-01 3.89e-01 0.15400 -1.53e-01 0.018700 4.75e-02 0.80900
Disorders of transmembrane transporters 105 1.41e-01 3.90e-01 0.11000 -1.06e-01 -0.032500 6.26e-02 0.56600
Toll Like Receptor 4 (TLR4) Cascade 93 1.41e-01 3.90e-01 0.11900 -1.19e-01 -0.000990 4.81e-02 0.98700
Formation of the Early Elongation Complex 29 1.41e-01 3.90e-01 0.21800 -1.57e-01 0.152000 1.44e-01 0.15700
Formation of the HIV-1 Early Elongation Complex 29 1.41e-01 3.90e-01 0.21800 -1.57e-01 0.152000 1.44e-01 0.15700
Degradation of GLI1 by the proteasome 51 1.41e-01 3.90e-01 0.15700 -1.46e-01 -0.058200 7.16e-02 0.47300
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 1.42e-01 3.92e-01 0.32000 2.08e-01 0.244000 2.13e-01 0.14400
Suppression of phagosomal maturation 12 1.43e-01 3.92e-01 0.32100 -2.70e-01 -0.173000 1.05e-01 0.30000
Pre-NOTCH Processing in Golgi 15 1.43e-01 3.92e-01 0.30200 -2.15e-01 0.213000 1.50e-01 0.15400
Activation of the pre-replicative complex 28 1.44e-01 3.92e-01 0.21200 2.06e-01 0.050800 5.92e-02 0.64200
G2/M Transition 153 1.44e-01 3.92e-01 0.09230 9.22e-02 0.004630 5.01e-02 0.92200
Degradation of the extracellular matrix 35 1.44e-01 3.94e-01 0.19400 -1.92e-01 0.028100 5.01e-02 0.77400
SARS-CoV-1 Infection 43 1.45e-01 3.94e-01 0.17200 -1.68e-01 -0.032100 5.63e-02 0.71600
Sensory processing of sound by outer hair cells of the cochlea 16 1.45e-01 3.94e-01 0.29000 -1.30e-01 0.259000 3.68e-01 0.07290
Platelet calcium homeostasis 17 1.46e-01 3.94e-01 0.26800 -1.42e-01 -0.227000 3.09e-01 0.10500
RNA Polymerase III Transcription Initiation From Type 2 Promoter 24 1.47e-01 3.96e-01 0.23500 -7.73e-02 0.222000 5.13e-01 0.06020
Constitutive Signaling by AKT1 E17K in Cancer 23 1.47e-01 3.97e-01 0.23700 -2.36e-01 0.023700 5.06e-02 0.84400
Ub-specific processing proteases 131 1.48e-01 3.97e-01 0.10200 8.54e-02 -0.055400 9.29e-02 0.27600
Regulation of PLK1 Activity at G2/M Transition 73 1.49e-01 3.98e-01 0.13300 1.32e-01 -0.008690 5.09e-02 0.89800
Signaling by the B Cell Receptor (BCR) 91 1.49e-01 3.98e-01 0.11800 -1.17e-01 -0.010500 5.34e-02 0.86300
Endosomal Sorting Complex Required For Transport (ESCRT) 27 1.54e-01 4.10e-01 0.21200 -2.05e-01 -0.054200 6.53e-02 0.62600
Cardiac conduction 40 1.55e-01 4.13e-01 0.17700 7.80e-03 -0.177000 9.32e-01 0.05360
Other semaphorin interactions 10 1.56e-01 4.13e-01 0.34300 -2.30e-01 -0.254000 2.08e-01 0.16400
DAG and IP3 signaling 26 1.56e-01 4.13e-01 0.22200 -6.46e-02 0.212000 5.69e-01 0.06160
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 1.56e-01 4.13e-01 0.33000 2.58e-01 -0.205000 1.22e-01 0.21800
Kinesins 31 1.57e-01 4.13e-01 0.19500 1.65e-01 0.104000 1.12e-01 0.31700
G1/S-Specific Transcription 25 1.58e-01 4.16e-01 0.22700 1.97e-01 -0.114000 8.89e-02 0.32600
Integration of energy metabolism 58 1.58e-01 4.16e-01 0.14800 -1.42e-01 0.041600 6.18e-02 0.58500
Phospholipid metabolism 129 1.60e-01 4.19e-01 0.10100 -7.74e-02 0.064200 1.30e-01 0.21000
Ephrin signaling 12 1.60e-01 4.20e-01 0.31500 -3.06e-01 -0.074700 6.69e-02 0.65400
Signaling by BMP 14 1.61e-01 4.20e-01 0.29900 2.88e-01 -0.081700 6.24e-02 0.59700
Signaling by WNT in cancer 22 1.61e-01 4.20e-01 0.23500 7.52e-03 0.235000 9.51e-01 0.05700
Synthesis of glycosylphosphatidylinositol (GPI) 13 1.65e-01 4.28e-01 0.29800 1.24e-01 0.271000 4.38e-01 0.09130
Synaptic adhesion-like molecules 10 1.65e-01 4.28e-01 0.33800 -2.74e-01 -0.197000 1.34e-01 0.28000
Trafficking and processing of endosomal TLR 10 1.66e-01 4.29e-01 0.34800 -4.31e-02 0.345000 8.13e-01 0.05860
FCERI mediated NF-kB activation 64 1.67e-01 4.31e-01 0.13600 -1.35e-01 -0.015500 6.21e-02 0.83100
Toll-like Receptor Cascades 108 1.69e-01 4.34e-01 0.10700 -1.02e-01 0.032700 6.82e-02 0.55900
FCERI mediated Ca+2 mobilization 25 1.70e-01 4.35e-01 0.21800 -8.36e-03 0.218000 9.42e-01 0.05990
Formation of HIV-1 elongation complex containing HIV-1 Tat 35 1.71e-01 4.35e-01 0.18800 -1.64e-01 0.091300 9.31e-02 0.35000
HIV Transcription Elongation 35 1.71e-01 4.35e-01 0.18800 -1.64e-01 0.091300 9.31e-02 0.35000
Tat-mediated elongation of the HIV-1 transcript 35 1.71e-01 4.35e-01 0.18800 -1.64e-01 0.091300 9.31e-02 0.35000
Metabolism of water-soluble vitamins and cofactors 79 1.71e-01 4.35e-01 0.12300 1.22e-01 -0.016800 6.12e-02 0.79700
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 1.72e-01 4.35e-01 0.34300 -8.55e-03 0.343000 9.63e-01 0.06060
alpha-linolenic acid (ALA) metabolism 10 1.72e-01 4.35e-01 0.34300 -8.55e-03 0.343000 9.63e-01 0.06060
Cell death signalling via NRAGE, NRIF and NADE 46 1.72e-01 4.35e-01 0.16300 -1.48e-01 0.069100 8.29e-02 0.41800
Metabolism of vitamins and cofactors 107 1.73e-01 4.36e-01 0.10400 1.04e-01 0.011500 6.45e-02 0.83800
Fatty acid metabolism 102 1.74e-01 4.37e-01 0.10800 -1.59e-02 0.107000 7.82e-01 0.06240
NRAGE signals death through JNK 31 1.76e-01 4.43e-01 0.19900 -1.23e-01 0.156000 2.36e-01 0.13300
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 19 1.77e-01 4.44e-01 0.25000 -2.41e-01 0.067300 6.95e-02 0.61200
Neurexins and neuroligins 20 1.78e-01 4.46e-01 0.24600 -2.02e-01 0.141000 1.19e-01 0.27500
HSF1 activation 21 1.80e-01 4.49e-01 0.23000 -2.21e-01 -0.064100 8.01e-02 0.61100
Fanconi Anemia Pathway 28 1.81e-01 4.51e-01 0.19700 1.56e-01 0.120000 1.53e-01 0.27400
Regulation of Apoptosis 45 1.82e-01 4.53e-01 0.15700 -1.53e-01 -0.034200 7.54e-02 0.69200
Recycling pathway of L1 16 1.84e-01 4.57e-01 0.26600 -2.66e-01 0.019100 6.59e-02 0.89500
Golgi Associated Vesicle Biogenesis 39 1.87e-01 4.61e-01 0.17400 -1.53e-01 0.081800 9.86e-02 0.37700
PI3K Cascade 18 1.87e-01 4.61e-01 0.24600 -2.38e-01 -0.062000 8.08e-02 0.64900
Factors involved in megakaryocyte development and platelet production 86 1.87e-01 4.61e-01 0.11200 6.23e-02 0.092500 3.19e-01 0.13900
FOXO-mediated transcription of cell death genes 14 1.87e-01 4.61e-01 0.28600 -2.77e-01 0.073800 7.33e-02 0.63300
Cell junction organization 25 1.89e-01 4.64e-01 0.20700 -1.95e-01 -0.070200 9.18e-02 0.54400
PIWI-interacting RNA (piRNA) biogenesis 15 1.90e-01 4.65e-01 0.27800 -2.43e-01 0.135000 1.03e-01 0.36700
Mitochondrial calcium ion transport 18 1.90e-01 4.65e-01 0.24400 -2.34e-01 -0.068400 8.53e-02 0.61600
Nephrin family interactions 14 1.91e-01 4.66e-01 0.27300 -2.26e-01 -0.154000 1.43e-01 0.31900
Signaling by NOTCH2 18 1.92e-01 4.66e-01 0.24300 -2.31e-01 -0.076600 9.01e-02 0.57400
Postmitotic nuclear pore complex (NPC) reformation 26 1.92e-01 4.66e-01 0.20300 1.98e-01 0.045400 8.06e-02 0.68900
C-type lectin receptors (CLRs) 100 1.92e-01 4.66e-01 0.10600 -1.05e-01 0.003930 6.93e-02 0.94600
Signaling by MET 42 1.93e-01 4.66e-01 0.16000 3.08e-02 0.157000 7.30e-01 0.07840
RAF-independent MAPK1/3 activation 20 1.94e-01 4.67e-01 0.23300 -2.32e-01 -0.020500 7.29e-02 0.87400
MAP kinase activation 50 1.94e-01 4.68e-01 0.14500 -1.31e-01 -0.062700 1.10e-01 0.44400
Purine salvage 11 1.97e-01 4.74e-01 0.31600 -5.40e-02 0.312000 7.57e-01 0.07350
Signal transduction by L1 11 1.98e-01 4.74e-01 0.32200 -2.50e-01 0.203000 1.52e-01 0.24400
Protein localization 122 1.98e-01 4.74e-01 0.09440 -9.44e-02 -0.001850 7.28e-02 0.97200
AKT phosphorylates targets in the cytosol 13 1.98e-01 4.74e-01 0.29300 -2.75e-01 0.100000 8.57e-02 0.53300
Degradation of beta-catenin by the destruction complex 68 2.00e-01 4.76e-01 0.12800 -1.24e-01 0.030700 7.81e-02 0.66200
Insulin receptor recycling 17 2.01e-01 4.76e-01 0.25600 -2.30e-01 0.113000 1.01e-01 0.42000
MAP2K and MAPK activation 25 2.01e-01 4.76e-01 0.20200 -1.73e-01 -0.105000 1.36e-01 0.36400
Inactivation of CSF3 (G-CSF) signaling 19 2.01e-01 4.76e-01 0.23500 -2.32e-01 -0.035200 7.96e-02 0.79100
Signaling by high-kinase activity BRAF mutants 22 2.01e-01 4.76e-01 0.21400 -1.53e-01 -0.150000 2.14e-01 0.22300
Branched-chain amino acid catabolism 19 2.02e-01 4.76e-01 0.24000 2.32e-01 -0.063800 8.05e-02 0.63000
Hedgehog ‘on’ state 61 2.03e-01 4.78e-01 0.12900 -1.15e-01 -0.059900 1.22e-01 0.42000
Host Interactions of HIV factors 106 2.04e-01 4.78e-01 0.10300 -9.10e-02 0.048000 1.07e-01 0.39500
Signaling by ERBB2 KD Mutants 11 2.04e-01 4.79e-01 0.30800 4.22e-02 0.305000 8.09e-01 0.08020
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 2.05e-01 4.79e-01 0.14900 -1.40e-01 -0.052700 1.02e-01 0.53700
TP53 Regulates Metabolic Genes 72 2.05e-01 4.79e-01 0.11800 -7.07e-02 -0.094900 3.01e-01 0.16500
RNA Polymerase II Transcription Termination 42 2.05e-01 4.79e-01 0.15700 3.57e-02 0.153000 6.89e-01 0.08740
Caspase activation via Death Receptors in the presence of ligand 10 2.09e-01 4.86e-01 0.33200 2.60e-01 -0.207000 1.55e-01 0.25800
TGF-beta receptor signaling activates SMADs 32 2.09e-01 4.86e-01 0.17900 -1.76e-01 -0.031400 8.50e-02 0.75900
Signaling by ERBB2 32 2.10e-01 4.86e-01 0.18400 -1.66e-01 0.080400 1.05e-01 0.43200
Signaling by EGFR in Cancer 16 2.10e-01 4.86e-01 0.26200 -1.81e-01 0.190000 2.11e-01 0.18900
Oncogene Induced Senescence 30 2.11e-01 4.87e-01 0.18100 -1.35e-01 -0.121000 2.02e-01 0.25100
Signaling by FGFR2 47 2.11e-01 4.87e-01 0.15000 -1.49e-01 0.017700 7.85e-02 0.83400
Early Phase of HIV Life Cycle 13 2.16e-01 4.97e-01 0.28700 -1.62e-01 0.238000 3.12e-01 0.13800
Gamma carboxylation, hypusine formation and arylsulfatase activation 22 2.18e-01 4.97e-01 0.21900 -1.99e-01 0.093700 1.07e-01 0.44700
Rab regulation of trafficking 89 2.19e-01 4.97e-01 0.10800 -1.06e-01 0.020100 8.42e-02 0.74400
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 41 2.19e-01 4.97e-01 0.15400 -1.33e-01 -0.076000 1.40e-01 0.40000
Constitutive Signaling by NOTCH1 PEST Domain Mutants 41 2.19e-01 4.97e-01 0.15400 -1.33e-01 -0.076000 1.40e-01 0.40000
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 41 2.19e-01 4.97e-01 0.15400 -1.33e-01 -0.076000 1.40e-01 0.40000
Signaling by NOTCH1 PEST Domain Mutants in Cancer 41 2.19e-01 4.97e-01 0.15400 -1.33e-01 -0.076000 1.40e-01 0.40000
Signaling by NOTCH1 in Cancer 41 2.19e-01 4.97e-01 0.15400 -1.33e-01 -0.076000 1.40e-01 0.40000
SLC-mediated transmembrane transport 97 2.20e-01 4.97e-01 0.10000 -9.13e-02 -0.041800 1.21e-01 0.47800
Signaling by Non-Receptor Tyrosine Kinases 33 2.24e-01 5.05e-01 0.17800 -1.55e-01 0.087000 1.23e-01 0.38800
Signaling by PTK6 33 2.24e-01 5.05e-01 0.17800 -1.55e-01 0.087000 1.23e-01 0.38800
Signaling by Hedgehog 97 2.25e-01 5.06e-01 0.10000 -9.55e-02 -0.030100 1.05e-01 0.61000
SUMOylation of chromatin organization proteins 49 2.26e-01 5.08e-01 0.13900 9.69e-02 0.099100 2.41e-01 0.23100
Regulation of TP53 Activity through Acetylation 26 2.28e-01 5.10e-01 0.19600 -1.94e-01 0.027600 8.68e-02 0.80800
Downstream signaling events of B Cell Receptor (BCR) 70 2.28e-01 5.10e-01 0.11800 -1.15e-01 -0.025100 9.73e-02 0.71700
HDACs deacetylate histones 28 2.28e-01 5.10e-01 0.18900 -1.86e-01 0.033000 8.80e-02 0.76200
VEGFR2 mediated vascular permeability 22 2.29e-01 5.11e-01 0.21400 -5.77e-02 0.206000 6.40e-01 0.09400
TRAF3-dependent IRF activation pathway 13 2.31e-01 5.13e-01 0.26700 2.13e-01 0.161000 1.84e-01 0.31400
Aggrephagy 18 2.31e-01 5.13e-01 0.23300 -2.33e-01 -0.003620 8.78e-02 0.97900
Gap-filling DNA repair synthesis and ligation in GG-NER 23 2.31e-01 5.13e-01 0.20700 -2.06e-01 0.019300 8.74e-02 0.87300
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 62 2.32e-01 5.13e-01 0.12200 -9.76e-02 -0.073900 1.85e-01 0.31500
Nuclear Events (kinase and transcription factor activation) 43 2.33e-01 5.13e-01 0.15200 -1.50e-01 0.019600 8.85e-02 0.82400
Infection with Mycobacterium tuberculosis 22 2.34e-01 5.14e-01 0.20500 -1.76e-01 -0.105000 1.54e-01 0.39300
DCC mediated attractive signaling 11 2.34e-01 5.14e-01 0.30100 -8.30e-02 0.289000 6.34e-01 0.09700
RNA Polymerase III Transcription Initiation From Type 1 Promoter 25 2.34e-01 5.14e-01 0.20100 -7.84e-02 0.185000 4.98e-01 0.11000
FGFR2 mutant receptor activation 15 2.35e-01 5.14e-01 0.25900 -2.39e-01 0.099800 1.10e-01 0.50300
SUMOylation 137 2.36e-01 5.16e-01 0.08210 6.09e-02 0.055200 2.21e-01 0.26700
Insulin receptor signalling cascade 26 2.36e-01 5.16e-01 0.18800 -1.63e-01 -0.092800 1.49e-01 0.41300
Notch-HLH transcription pathway 21 2.37e-01 5.17e-01 0.21500 -2.14e-01 0.024500 9.03e-02 0.84600
CaM pathway 20 2.41e-01 5.23e-01 0.22400 -1.61e-01 0.156000 2.13e-01 0.22800
Calmodulin induced events 20 2.41e-01 5.23e-01 0.22400 -1.61e-01 0.156000 2.13e-01 0.22800
Signaling by TGFB family members 73 2.45e-01 5.31e-01 0.11100 -7.00e-02 -0.085700 3.02e-01 0.20600
CDK-mediated phosphorylation and removal of Cdc6 62 2.48e-01 5.36e-01 0.12100 -1.14e-01 -0.040800 1.23e-01 0.58000
SUMO E3 ligases SUMOylate target proteins 131 2.53e-01 5.45e-01 0.08210 4.61e-02 0.067900 3.64e-01 0.18100
RHOC GTPase cycle 49 2.54e-01 5.45e-01 0.14000 -5.75e-02 0.127000 4.87e-01 0.12400
Cyclin D associated events in G1 41 2.54e-01 5.45e-01 0.15300 8.74e-02 -0.126000 3.34e-01 0.16300
G1 Phase 41 2.54e-01 5.45e-01 0.15300 8.74e-02 -0.126000 3.34e-01 0.16300
Signaling by ERBB4 31 2.55e-01 5.46e-01 0.16700 -1.37e-01 -0.095500 1.86e-01 0.35800
Signaling by RAF1 mutants 25 2.57e-01 5.49e-01 0.18600 -1.09e-01 -0.150000 3.45e-01 0.19400
Circadian Clock 50 2.57e-01 5.49e-01 0.13800 -5.36e-02 0.127000 5.12e-01 0.12200
Interleukin-3, Interleukin-5 and GM-CSF signaling 30 2.60e-01 5.52e-01 0.17700 -1.54e-01 0.088000 1.45e-01 0.40500
Inactivation, recovery and regulation of the phototransduction cascade 16 2.60e-01 5.52e-01 0.23100 1.56e-01 0.170000 2.80e-01 0.24000
The phototransduction cascade 16 2.60e-01 5.52e-01 0.23100 1.56e-01 0.170000 2.80e-01 0.24000
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 64 2.60e-01 5.52e-01 0.11700 -1.10e-01 -0.039500 1.30e-01 0.58500
Attenuation phase 19 2.61e-01 5.52e-01 0.21200 -1.91e-01 -0.092900 1.50e-01 0.48400
Ca-dependent events 21 2.61e-01 5.52e-01 0.21200 -1.61e-01 0.138000 2.01e-01 0.27400
Semaphorin interactions 39 2.63e-01 5.54e-01 0.15000 -1.48e-01 -0.023000 1.10e-01 0.80400
N-Glycan antennae elongation 11 2.64e-01 5.54e-01 0.28600 -2.84e-01 0.035400 1.03e-01 0.83900
RIPK1-mediated regulated necrosis 24 2.64e-01 5.54e-01 0.19500 4.22e-02 -0.190000 7.20e-01 0.10800
Regulation of necroptotic cell death 24 2.64e-01 5.54e-01 0.19500 4.22e-02 -0.190000 7.20e-01 0.10800
Syndecan interactions 10 2.65e-01 5.54e-01 0.29300 -2.80e-01 -0.086600 1.26e-01 0.63500
Formation of HIV elongation complex in the absence of HIV Tat 36 2.65e-01 5.55e-01 0.16100 -1.40e-01 0.078800 1.47e-01 0.41400
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 38 2.66e-01 5.55e-01 0.15600 8.23e-02 -0.133000 3.81e-01 0.15600
Gene Silencing by RNA 60 2.68e-01 5.55e-01 0.11800 9.87e-02 0.065200 1.87e-01 0.38300
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 63 2.68e-01 5.55e-01 0.11500 -8.53e-02 -0.077300 2.43e-01 0.28900
Regulation of signaling by CBL 14 2.69e-01 5.55e-01 0.25700 -1.96e-01 0.166000 2.03e-01 0.28300
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 2.69e-01 5.55e-01 0.17600 -1.45e-01 -0.099500 1.94e-01 0.37100
Transferrin endocytosis and recycling 19 2.69e-01 5.55e-01 0.22000 -1.76e-01 0.132000 1.84e-01 0.31900
RHOB GTPase cycle 44 2.70e-01 5.55e-01 0.14100 -8.60e-03 0.141000 9.21e-01 0.10600
Gap junction trafficking and regulation 10 2.70e-01 5.55e-01 0.29100 -2.83e-01 -0.070300 1.22e-01 0.70000
HCMV Early Events 50 2.70e-01 5.55e-01 0.13300 1.32e-01 -0.010300 1.06e-01 0.89900
Downregulation of SMAD2/3:SMAD4 transcriptional activity 22 2.70e-01 5.55e-01 0.19900 -7.04e-04 -0.199000 9.95e-01 0.10600
LDL clearance 13 2.71e-01 5.56e-01 0.25700 -2.54e-01 -0.034100 1.12e-01 0.83200
Transport of inorganic cations/anions and amino acids/oligopeptides 41 2.72e-01 5.57e-01 0.14200 -9.32e-02 -0.107000 3.03e-01 0.23700
N-glycan antennae elongation in the medial/trans-Golgi 17 2.74e-01 5.59e-01 0.23000 -2.11e-01 0.090800 1.32e-01 0.51700
RET signaling 22 2.74e-01 5.59e-01 0.19500 -1.88e-01 -0.052200 1.27e-01 0.67200
MTOR signalling 37 2.75e-01 5.59e-01 0.15700 -1.23e-01 0.098000 1.97e-01 0.30300
MyD88-independent TLR4 cascade 75 2.76e-01 5.59e-01 0.10600 -1.05e-01 -0.016100 1.16e-01 0.81000
TRIF(TICAM1)-mediated TLR4 signaling 75 2.76e-01 5.59e-01 0.10600 -1.05e-01 -0.016100 1.16e-01 0.81000
Downregulation of TGF-beta receptor signaling 26 2.76e-01 5.59e-01 0.17700 -1.21e-01 -0.129000 2.86e-01 0.25600
Synthesis of PIPs at the early endosome membrane 12 2.79e-01 5.63e-01 0.27300 2.33e-01 -0.143000 1.63e-01 0.39100
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 28 2.80e-01 5.63e-01 0.17800 -7.72e-02 0.160000 4.80e-01 0.14200
Cross-presentation of soluble exogenous antigens (endosomes) 38 2.80e-01 5.63e-01 0.14800 -1.47e-01 -0.020300 1.17e-01 0.82900
G0 and Early G1 24 2.80e-01 5.64e-01 0.18500 1.74e-01 0.061500 1.40e-01 0.60200
CDC42 GTPase cycle 96 2.86e-01 5.73e-01 0.09610 -8.04e-02 0.052600 1.75e-01 0.37400
Constitutive Signaling by EGFRvIII 10 2.86e-01 5.73e-01 0.28100 1.55e-01 0.235000 3.97e-01 0.19800
Signaling by EGFRvIII in Cancer 10 2.86e-01 5.73e-01 0.28100 1.55e-01 0.235000 3.97e-01 0.19800
Processing of Intronless Pre-mRNAs 14 2.88e-01 5.75e-01 0.23700 1.36e-01 0.195000 3.79e-01 0.20800
Gastrin-CREB signalling pathway via PKC and MAPK 12 2.90e-01 5.77e-01 0.26900 -2.21e-01 0.154000 1.85e-01 0.35600
Telomere Maintenance 55 2.91e-01 5.78e-01 0.12600 -9.99e-02 0.076700 2.01e-01 0.32600
IRS-related events triggered by IGF1R 22 2.91e-01 5.78e-01 0.18800 -1.53e-01 -0.111000 2.16e-01 0.37000
ADORA2B mediated anti-inflammatory cytokines production 30 2.92e-01 5.78e-01 0.17000 -1.36e-01 0.102000 1.97e-01 0.33600
Processing of SMDT1 12 2.92e-01 5.78e-01 0.25600 -2.31e-01 -0.109000 1.65e-01 0.51300
Gap-filling DNA repair synthesis and ligation in TC-NER 54 2.92e-01 5.78e-01 0.12400 -1.23e-01 0.018200 1.18e-01 0.81700
Amino acid transport across the plasma membrane 16 2.93e-01 5.78e-01 0.22300 -5.55e-02 -0.216000 7.01e-01 0.13500
Erythropoietin activates RAS 11 2.93e-01 5.78e-01 0.27700 -9.21e-02 0.261000 5.97e-01 0.13300
Thrombin signalling through proteinase activated receptors (PARs) 19 2.95e-01 5.79e-01 0.20900 -2.06e-01 0.033200 1.20e-01 0.80300
Golgi-to-ER retrograde transport 92 2.96e-01 5.80e-01 0.09260 3.36e-02 0.086300 5.79e-01 0.15400
Phosphorylation of CD3 and TCR zeta chains 10 2.96e-01 5.80e-01 0.28000 -9.96e-02 -0.261000 5.86e-01 0.15300
HIV Infection 188 2.97e-01 5.80e-01 0.06810 -5.21e-02 0.043900 2.21e-01 0.30200
Sealing of the nuclear envelope (NE) by ESCRT-III 19 2.97e-01 5.80e-01 0.20600 -2.06e-01 0.002240 1.20e-01 0.98700
TP53 Regulates Transcription of Cell Cycle Genes 42 2.97e-01 5.80e-01 0.14300 1.18e-01 -0.079300 1.85e-01 0.37500
SUMOylation of DNA methylation proteins 14 2.98e-01 5.80e-01 0.24300 -2.37e-01 0.049600 1.24e-01 0.74800
IRE1alpha activates chaperones 37 2.99e-01 5.81e-01 0.15000 -1.45e-01 0.038200 1.28e-01 0.68800
Formation of the beta-catenin:TCF transactivating complex 24 2.99e-01 5.81e-01 0.18300 -2.81e-03 0.183000 9.81e-01 0.12100
Signaling by ERBB2 ECD mutants 10 3.00e-01 5.81e-01 0.27700 1.36e-01 0.241000 4.58e-01 0.18700
Signaling by Erythropoietin 20 3.03e-01 5.86e-01 0.20500 -1.64e-01 0.123000 2.05e-01 0.34000
Role of phospholipids in phagocytosis 16 3.04e-01 5.87e-01 0.22700 -9.16e-02 0.208000 5.26e-01 0.15000
Diseases of metabolism 120 3.05e-01 5.87e-01 0.08210 -8.17e-02 0.007690 1.24e-01 0.88500
Metabolism of cofactors 17 3.05e-01 5.87e-01 0.21700 2.16e-01 -0.020700 1.24e-01 0.88200
PKA activation 10 3.09e-01 5.93e-01 0.28700 -2.46e-01 0.147000 1.78e-01 0.42000
ERK/MAPK targets 17 3.10e-01 5.94e-01 0.22000 -1.23e-01 0.182000 3.78e-01 0.19400
Metabolism of nucleotides 68 3.11e-01 5.95e-01 0.10800 -1.07e-01 0.011200 1.27e-01 0.87400
MHC class II antigen presentation 70 3.13e-01 5.99e-01 0.10700 -3.09e-02 0.102000 6.56e-01 0.13900
Protein-protein interactions at synapses 32 3.16e-01 6.02e-01 0.15500 -1.55e-01 -0.003140 1.30e-01 0.97500
Transcriptional regulation by RUNX3 75 3.16e-01 6.02e-01 0.10000 -9.66e-02 -0.026200 1.49e-01 0.69600
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 16 3.17e-01 6.02e-01 0.22100 -2.17e-01 0.043800 1.34e-01 0.76200
Signaling by Leptin 10 3.17e-01 6.02e-01 0.28100 -2.67e-01 0.088800 1.44e-01 0.62700
Iron uptake and transport 38 3.18e-01 6.03e-01 0.14300 -1.42e-01 0.011500 1.30e-01 0.90200
Dopamine Neurotransmitter Release Cycle 12 3.19e-01 6.03e-01 0.25900 -1.95e-01 0.170000 2.42e-01 0.30700
APC-Cdc20 mediated degradation of Nek2A 24 3.19e-01 6.03e-01 0.17600 -3.31e-02 -0.173000 7.79e-01 0.14200
Opioid Signalling 56 3.22e-01 6.07e-01 0.12000 -7.00e-02 0.097000 3.66e-01 0.21000
Interleukin-7 signaling 14 3.23e-01 6.09e-01 0.23800 -1.53e-01 0.182000 3.21e-01 0.23800
Generation of second messenger molecules 16 3.26e-01 6.14e-01 0.21300 -5.51e-02 -0.206000 7.03e-01 0.15500
mRNA 3’-end processing 35 3.30e-01 6.17e-01 0.14200 1.05e-01 0.095400 2.84e-01 0.32900
Sensory processing of sound 25 3.30e-01 6.17e-01 0.17600 -1.55e-01 0.083500 1.80e-01 0.47100
Sensory processing of sound by inner hair cells of the cochlea 25 3.30e-01 6.17e-01 0.17600 -1.55e-01 0.083500 1.80e-01 0.47100
Signaling by CSF3 (G-CSF) 24 3.31e-01 6.19e-01 0.17500 -1.75e-01 -0.005400 1.39e-01 0.96400
Regulation of BACH1 activity 11 3.32e-01 6.20e-01 0.25200 -1.41e-01 -0.209000 4.20e-01 0.23000
FCERI mediated MAPK activation 25 3.33e-01 6.20e-01 0.17600 -1.37e-01 0.110000 2.35e-01 0.34200
G alpha (i) signalling events 87 3.34e-01 6.20e-01 0.09340 -8.98e-02 0.025700 1.49e-01 0.68000
Toll Like Receptor 3 (TLR3) Cascade 75 3.34e-01 6.20e-01 0.09860 -9.83e-02 -0.007410 1.42e-01 0.91200
Transcriptional regulation by RUNX2 83 3.37e-01 6.24e-01 0.09150 -7.61e-02 -0.050800 2.32e-01 0.42500
CDT1 association with the CDC6:ORC:origin complex 50 3.37e-01 6.24e-01 0.11700 -8.43e-02 -0.081600 3.03e-01 0.31900
CTLA4 inhibitory signaling 16 3.38e-01 6.24e-01 0.20900 -7.21e-02 -0.196000 6.18e-01 0.17500
Glucose metabolism 72 3.39e-01 6.25e-01 0.10200 -9.66e-02 0.033000 1.57e-01 0.62900
RHO GTPases Activate WASPs and WAVEs 29 3.39e-01 6.25e-01 0.16100 -1.43e-01 0.075300 1.84e-01 0.48300
RAF activation 28 3.40e-01 6.26e-01 0.16100 1.60e-01 -0.006790 1.42e-01 0.95000
RUNX1 regulates transcription of genes involved in differentiation of HSCs 56 3.41e-01 6.26e-01 0.11100 -9.75e-02 -0.052700 2.08e-01 0.49600
Post-translational protein phosphorylation 32 3.42e-01 6.27e-01 0.15000 -1.50e-01 0.010600 1.43e-01 0.91700
Stimuli-sensing channels 39 3.43e-01 6.27e-01 0.13900 -9.55e-02 0.101000 3.03e-01 0.27400
Activation of NMDA receptors and postsynaptic events 43 3.43e-01 6.27e-01 0.12800 -1.26e-01 -0.020300 1.53e-01 0.81800
Sensory Perception 62 3.44e-01 6.28e-01 0.11000 -7.57e-02 0.080300 3.03e-01 0.27500
Inositol phosphate metabolism 29 3.45e-01 6.28e-01 0.16100 -1.27e-01 0.098200 2.35e-01 0.36100
CD28 dependent PI3K/Akt signaling 18 3.46e-01 6.29e-01 0.19700 -1.96e-01 -0.019700 1.50e-01 0.88500
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 10 3.46e-01 6.29e-01 0.26800 2.64e-01 -0.044500 1.48e-01 0.80800
The role of GTSE1 in G2/M progression after G2 checkpoint 52 3.47e-01 6.30e-01 0.11400 -1.00e-01 -0.054100 2.11e-01 0.50100
Signaling by Retinoic Acid 17 3.49e-01 6.32e-01 0.19800 -1.22e-01 -0.155000 3.83e-01 0.26700
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 14 3.50e-01 6.33e-01 0.22600 -2.22e-01 0.042700 1.51e-01 0.78200
GPVI-mediated activation cascade 24 3.51e-01 6.33e-01 0.17400 -1.62e-01 0.063700 1.71e-01 0.58900
Collagen degradation 14 3.51e-01 6.33e-01 0.22900 -1.78e-01 0.144000 2.49e-01 0.35000
MAPK targets/ Nuclear events mediated by MAP kinases 24 3.53e-01 6.33e-01 0.17400 -1.53e-01 0.082800 1.94e-01 0.48300
Glutamate binding, activation of AMPA receptors and synaptic plasticity 12 3.53e-01 6.33e-01 0.23800 -2.33e-01 -0.048100 1.63e-01 0.77300
Trafficking of AMPA receptors 12 3.53e-01 6.33e-01 0.23800 -2.33e-01 -0.048100 1.63e-01 0.77300
Regulation of RAS by GAPs 56 3.53e-01 6.33e-01 0.11200 -1.12e-01 0.004190 1.49e-01 0.95700
Mitotic G1 phase and G1/S transition 127 3.55e-01 6.35e-01 0.07610 6.28e-02 -0.043000 2.23e-01 0.40500
Translocation of SLC2A4 (GLUT4) to the plasma membrane 45 3.57e-01 6.38e-01 0.12400 1.24e-01 -0.013700 1.52e-01 0.87400
Regulation of TP53 Activity through Methylation 17 3.60e-01 6.41e-01 0.19800 -3.65e-02 -0.195000 7.94e-01 0.16500
Telomere C-strand synthesis initiation 10 3.61e-01 6.41e-01 0.26100 -1.71e-02 0.261000 9.25e-01 0.15300
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 68 3.61e-01 6.41e-01 0.10000 -1.00e-01 0.003950 1.54e-01 0.95500
Response of EIF2AK1 (HRI) to heme deficiency 13 3.61e-01 6.41e-01 0.23500 1.88e-01 -0.141000 2.41e-01 0.38100
APC/C:Cdc20 mediated degradation of mitotic proteins 65 3.63e-01 6.43e-01 0.09950 -6.82e-02 -0.072400 3.42e-01 0.31400
Signaling by FGFR2 IIIa TM 14 3.64e-01 6.43e-01 0.22200 -2.14e-01 0.061600 1.66e-01 0.69000
CLEC7A (Dectin-1) induces NFAT activation 11 3.65e-01 6.43e-01 0.24300 8.66e-02 0.227000 6.19e-01 0.19300
XBP1(S) activates chaperone genes 36 3.65e-01 6.43e-01 0.13800 -1.36e-01 0.021200 1.58e-01 0.82600
G alpha (s) signalling events 38 3.66e-01 6.44e-01 0.13600 -1.20e-01 0.063400 2.00e-01 0.49900
Basigin interactions 14 3.66e-01 6.44e-01 0.21300 -1.54e-01 -0.146000 3.17e-01 0.34300
Metabolism of fat-soluble vitamins 12 3.68e-01 6.46e-01 0.24200 -1.66e-01 0.177000 3.21e-01 0.29000
RHO GTPases activate CIT 14 3.69e-01 6.46e-01 0.22300 1.09e-01 -0.195000 4.81e-01 0.20700
RMTs methylate histone arginines 25 3.69e-01 6.46e-01 0.16800 -1.20e-01 0.117000 2.99e-01 0.31100
O-linked glycosylation 42 3.70e-01 6.46e-01 0.12700 -1.25e-01 0.018700 1.60e-01 0.83500
Signaling by FGFR 51 3.71e-01 6.46e-01 0.11600 -1.06e-01 0.047800 1.90e-01 0.55600
Interleukin-12 signaling 35 3.71e-01 6.46e-01 0.14100 -8.05e-02 0.116000 4.10e-01 0.23600
Regulation of RUNX2 expression and activity 57 3.71e-01 6.46e-01 0.10500 -8.08e-02 -0.067100 2.93e-01 0.38100
Regulation of beta-cell development 14 3.73e-01 6.48e-01 0.21900 -2.15e-01 0.037200 1.63e-01 0.81000
Purine catabolism 10 3.73e-01 6.48e-01 0.26300 -1.36e-01 0.224000 4.56e-01 0.21900
Synthesis of bile acids and bile salts 13 3.74e-01 6.48e-01 0.22600 2.24e-01 -0.035300 1.63e-01 0.82600
Deadenylation of mRNA 21 3.75e-01 6.48e-01 0.17900 1.70e-01 -0.055600 1.77e-01 0.65900
G1/S Transition 113 3.75e-01 6.48e-01 0.07850 6.32e-02 -0.046500 2.47e-01 0.39500
Disorders of Developmental Biology 10 3.78e-01 6.49e-01 0.24800 -1.75e-01 -0.175000 3.37e-01 0.33800
Disorders of Nervous System Development 10 3.78e-01 6.49e-01 0.24800 -1.75e-01 -0.175000 3.37e-01 0.33800
Loss of function of MECP2 in Rett syndrome 10 3.78e-01 6.49e-01 0.24800 -1.75e-01 -0.175000 3.37e-01 0.33800
Pervasive developmental disorders 10 3.78e-01 6.49e-01 0.24800 -1.75e-01 -0.175000 3.37e-01 0.33800
Interconversion of nucleotide di- and triphosphates 22 3.80e-01 6.52e-01 0.16700 -1.02e-01 -0.132000 4.10e-01 0.28300
Regulation of APC/C activators between G1/S and early anaphase 70 3.82e-01 6.52e-01 0.09360 -5.41e-02 -0.076400 4.35e-01 0.27000
Assembly and cell surface presentation of NMDA receptors 12 3.83e-01 6.52e-01 0.23700 -1.26e-01 0.200000 4.51e-01 0.22900
Formation of Incision Complex in GG-NER 36 3.84e-01 6.52e-01 0.13000 1.16e-01 0.059500 2.29e-01 0.53700
Ion transport by P-type ATPases 27 3.84e-01 6.52e-01 0.15700 6.96e-02 -0.141000 5.32e-01 0.20500
MicroRNA (miRNA) biogenesis 20 3.84e-01 6.52e-01 0.18300 -1.64e-01 0.079800 2.04e-01 0.53700
NGF-stimulated transcription 25 3.84e-01 6.52e-01 0.15600 -1.40e-01 -0.069900 2.26e-01 0.54600
Chaperonin-mediated protein folding 56 3.86e-01 6.54e-01 0.11000 -7.57e-02 0.079300 3.28e-01 0.30500
Signaling by PDGFR in disease 16 3.86e-01 6.54e-01 0.19500 1.76e-01 0.084600 2.24e-01 0.55800
Regulation of IFNA signaling 12 3.87e-01 6.54e-01 0.23400 8.74e-02 -0.217000 6.00e-01 0.19300
Programmed Cell Death 153 3.87e-01 6.54e-01 0.06350 -2.55e-02 -0.058100 5.88e-01 0.21700
G alpha (z) signalling events 24 3.89e-01 6.55e-01 0.16700 -1.10e-01 0.125000 3.53e-01 0.28800
RND2 GTPase cycle 32 3.89e-01 6.55e-01 0.14100 -1.46e-02 0.140000 8.87e-01 0.17000
SUMOylation of RNA binding proteins 42 3.90e-01 6.55e-01 0.12100 1.19e-01 0.022100 1.82e-01 0.80400
RHOD GTPase cycle 37 3.90e-01 6.55e-01 0.12700 1.13e-01 0.058500 2.34e-01 0.53800
RAC2 GTPase cycle 58 3.91e-01 6.55e-01 0.10700 -9.02e-02 0.057100 2.35e-01 0.45300
Triglyceride metabolism 16 3.91e-01 6.55e-01 0.19400 7.33e-02 0.180000 6.12e-01 0.21400
APC/C:Cdc20 mediated degradation of Cyclin B 22 3.92e-01 6.56e-01 0.16500 -6.87e-02 -0.150000 5.77e-01 0.22400
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 66 3.96e-01 6.60e-01 0.09440 -6.51e-02 -0.068400 3.62e-01 0.33700
Nucleotide Excision Repair 98 3.96e-01 6.60e-01 0.08050 -7.91e-02 0.015400 1.78e-01 0.79300
Initiation of Nuclear Envelope (NE) Reformation 17 3.98e-01 6.61e-01 0.19400 1.78e-01 -0.076700 2.04e-01 0.58400
G beta:gamma signalling through CDC42 12 3.98e-01 6.61e-01 0.22000 1.49e-01 0.162000 3.73e-01 0.33000
Peroxisomal lipid metabolism 22 3.98e-01 6.61e-01 0.16300 1.07e-01 0.122000 3.83e-01 0.32200
Defects in vitamin and cofactor metabolism 16 3.99e-01 6.61e-01 0.20000 1.84e-01 -0.077200 2.03e-01 0.59300
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 33 3.99e-01 6.61e-01 0.13800 -3.71e-02 0.133000 7.12e-01 0.18600
Post NMDA receptor activation events 38 4.01e-01 6.63e-01 0.12300 -9.98e-02 -0.072800 2.88e-01 0.43800
IRS-mediated signalling 21 4.02e-01 6.64e-01 0.16600 -1.46e-01 -0.079600 2.47e-01 0.52800
Apoptotic factor-mediated response 15 4.03e-01 6.64e-01 0.19700 -7.69e-02 -0.181000 6.06e-01 0.22400
RND3 GTPase cycle 28 4.04e-01 6.65e-01 0.14800 -2.57e-02 0.146000 8.14e-01 0.18100
DNA Damage/Telomere Stress Induced Senescence 23 4.05e-01 6.66e-01 0.15900 5.86e-02 0.148000 6.27e-01 0.22100
Nucleotide salvage 18 4.06e-01 6.67e-01 0.18800 -1.43e-01 0.122000 2.94e-01 0.37200
NCAM signaling for neurite out-growth 22 4.07e-01 6.67e-01 0.16200 -5.56e-02 -0.152000 6.52e-01 0.21600
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 10 4.10e-01 6.71e-01 0.25000 2.16e-01 -0.126000 2.38e-01 0.49000
Beta-catenin phosphorylation cascade 15 4.11e-01 6.72e-01 0.19900 -6.88e-04 0.199000 9.96e-01 0.18300
Platelet homeostasis 48 4.11e-01 6.72e-01 0.10900 -3.38e-02 -0.104000 6.86e-01 0.21300
Formation of TC-NER Pre-Incision Complex 45 4.14e-01 6.73e-01 0.11300 -1.11e-01 -0.021000 1.97e-01 0.80800
RHOV GTPase cycle 24 4.14e-01 6.73e-01 0.15800 3.03e-02 -0.155000 7.98e-01 0.18800
SUMOylation of transcription cofactors 35 4.14e-01 6.73e-01 0.13300 -9.36e-02 0.095100 3.38e-01 0.33100
Apoptotic execution phase 33 4.14e-01 6.73e-01 0.13300 1.33e-01 0.006350 1.87e-01 0.95000
InlB-mediated entry of Listeria monocytogenes into host cell 11 4.15e-01 6.73e-01 0.23300 -2.29e-01 0.046400 1.89e-01 0.79000
Sema3A PAK dependent Axon repulsion 11 4.16e-01 6.74e-01 0.22400 -1.73e-01 -0.143000 3.22e-01 0.41100
Assembly of collagen fibrils and other multimeric structures 14 4.17e-01 6.74e-01 0.20800 -7.89e-02 0.193000 6.09e-01 0.21200
DAP12 signaling 21 4.18e-01 6.75e-01 0.17000 -6.58e-02 0.156000 6.02e-01 0.21500
RUNX2 regulates osteoblast differentiation 12 4.21e-01 6.78e-01 0.21400 -1.10e-01 -0.184000 5.11e-01 0.27100
PKA-mediated phosphorylation of CREB 11 4.22e-01 6.78e-01 0.23500 -1.73e-01 0.159000 3.20e-01 0.36200
NR1H2 and NR1H3-mediated signaling 26 4.22e-01 6.78e-01 0.14600 -1.40e-01 -0.043100 2.17e-01 0.70400
Telomere Extension By Telomerase 20 4.22e-01 6.78e-01 0.17300 -7.30e-02 0.157000 5.72e-01 0.22500
Negative regulators of DDX58/IFIH1 signaling 33 4.23e-01 6.78e-01 0.13500 6.21e-02 -0.120000 5.37e-01 0.23400
Translesion synthesis by POLI 15 4.24e-01 6.78e-01 0.20000 -9.29e-02 0.177000 5.34e-01 0.23600
Nucleobase biosynthesis 10 4.26e-01 6.81e-01 0.23300 -2.00e-01 -0.119000 2.75e-01 0.51300
Regulation of pyruvate dehydrogenase (PDH) complex 11 4.27e-01 6.81e-01 0.22400 2.19e-01 0.049500 2.09e-01 0.77600
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 4.27e-01 6.81e-01 0.15400 1.41e-01 0.062500 2.43e-01 0.60400
Pyroptosis 18 4.30e-01 6.84e-01 0.18000 5.16e-02 -0.172000 7.05e-01 0.20700
CD28 co-stimulation 27 4.30e-01 6.84e-01 0.14600 -1.41e-01 0.038000 2.04e-01 0.73300
Transport of vitamins, nucleosides, and related molecules 21 4.31e-01 6.84e-01 0.16600 -4.56e-02 0.159000 7.18e-01 0.20600
Translesion synthesis by REV1 14 4.31e-01 6.84e-01 0.20600 -1.60e-01 0.129000 3.00e-01 0.40300
Zinc transporters 11 4.33e-01 6.85e-01 0.22500 -8.77e-03 -0.225000 9.60e-01 0.19700
Activation of BH3-only proteins 27 4.35e-01 6.88e-01 0.14000 -1.25e-01 -0.063100 2.60e-01 0.57100
RHOQ GTPase cycle 39 4.37e-01 6.89e-01 0.11900 -6.60e-03 0.119000 9.43e-01 0.19800
DAP12 interactions 23 4.37e-01 6.89e-01 0.15800 -7.38e-02 0.140000 5.41e-01 0.24500
ERKs are inactivated 12 4.37e-01 6.89e-01 0.21700 -2.08e-01 0.062900 2.12e-01 0.70600
Class B/2 (Secretin family receptors) 26 4.38e-01 6.89e-01 0.15000 -1.16e-01 0.094900 3.08e-01 0.40300
Role of LAT2/NTAL/LAB on calcium mobilization 11 4.40e-01 6.91e-01 0.22600 -2.20e-01 0.049600 2.07e-01 0.77600
Translesion Synthesis by POLH 16 4.40e-01 6.91e-01 0.19000 -1.60e-01 0.102000 2.69e-01 0.48000
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 16 4.43e-01 6.91e-01 0.18000 -1.56e-01 -0.090100 2.81e-01 0.53300
SCF(Skp2)-mediated degradation of p27/p21 52 4.43e-01 6.91e-01 0.10100 -9.53e-02 -0.032100 2.35e-01 0.68900
DNA Damage Bypass 41 4.44e-01 6.91e-01 0.11200 6.61e-02 0.090500 4.65e-01 0.31700
Protein folding 62 4.45e-01 6.91e-01 0.09590 -8.16e-02 0.050300 2.67e-01 0.49400
Regulation of TP53 Activity 131 4.45e-01 6.91e-01 0.06480 6.46e-02 -0.005770 2.04e-01 0.91000
IGF1R signaling cascade 23 4.46e-01 6.91e-01 0.15000 -1.31e-01 -0.072700 2.78e-01 0.54600
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 23 4.46e-01 6.91e-01 0.15000 -1.31e-01 -0.072700 2.78e-01 0.54600
PKMTs methylate histone lysines 30 4.46e-01 6.91e-01 0.13800 1.13e-01 -0.077900 2.83e-01 0.46100
FGFR2 alternative splicing 21 4.46e-01 6.91e-01 0.16400 -1.48e-01 0.070400 2.42e-01 0.57700
Diseases of glycosylation 68 4.47e-01 6.93e-01 0.09120 -7.94e-02 0.044800 2.59e-01 0.52300
RNA Polymerase I Promoter Escape 24 4.49e-01 6.94e-01 0.14600 1.29e-01 0.068400 2.75e-01 0.56200
Asparagine N-linked glycosylation 222 4.49e-01 6.94e-01 0.04900 -4.81e-02 -0.009570 2.20e-01 0.80700
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 33 4.51e-01 6.96e-01 0.12600 -1.24e-01 -0.019900 2.18e-01 0.84300
Meiotic synapsis 23 4.52e-01 6.96e-01 0.15600 1.08e-01 -0.112000 3.69e-01 0.35100
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 17 4.53e-01 6.97e-01 0.17900 1.72e-01 -0.049500 2.20e-01 0.72400
Paradoxical activation of RAF signaling by kinase inactive BRAF 29 4.59e-01 7.02e-01 0.13100 -1.06e-01 -0.075800 3.22e-01 0.48000
Signaling by RAS mutants 29 4.59e-01 7.02e-01 0.13100 -1.06e-01 -0.075800 3.22e-01 0.48000
Signaling by moderate kinase activity BRAF mutants 29 4.59e-01 7.02e-01 0.13100 -1.06e-01 -0.075800 3.22e-01 0.48000
Signaling downstream of RAS mutants 29 4.59e-01 7.02e-01 0.13100 -1.06e-01 -0.075800 3.22e-01 0.48000
Ion channel transport 80 4.59e-01 7.02e-01 0.08150 -8.04e-02 0.013600 2.15e-01 0.83400
Other interleukin signaling 15 4.65e-01 7.09e-01 0.18700 -1.78e-01 0.059800 2.34e-01 0.68900
Apoptosis 132 4.65e-01 7.09e-01 0.06090 -4.10e-02 -0.045000 4.18e-01 0.37400
Ion homeostasis 26 4.66e-01 7.09e-01 0.13700 -6.87e-02 -0.118000 5.45e-01 0.29800
RHO GTPases activate PAKs 13 4.66e-01 7.09e-01 0.20200 1.82e-01 -0.087500 2.56e-01 0.58500
Cytochrome P450 - arranged by substrate type 14 4.69e-01 7.10e-01 0.18600 1.74e-01 0.067600 2.61e-01 0.66200
Inactivation of APC/C via direct inhibition of the APC/C complex 19 4.69e-01 7.10e-01 0.16700 8.03e-02 -0.146000 5.45e-01 0.27000
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 4.69e-01 7.10e-01 0.16700 8.03e-02 -0.146000 5.45e-01 0.27000
Cargo trafficking to the periciliary membrane 40 4.70e-01 7.10e-01 0.11400 1.09e-01 -0.033200 2.33e-01 0.71700
Assembly of the pre-replicative complex 59 4.71e-01 7.12e-01 0.09000 -7.11e-02 -0.055100 3.46e-01 0.46500
Transport of bile salts and organic acids, metal ions and amine compounds 30 4.78e-01 7.21e-01 0.12500 -8.55e-02 -0.090900 4.18e-01 0.38900
Phosphorylation of the APC/C 18 4.80e-01 7.21e-01 0.16900 9.97e-02 -0.137000 4.64e-01 0.31500
VxPx cargo-targeting to cilium 16 4.80e-01 7.21e-01 0.17600 1.75e-01 -0.015100 2.26e-01 0.91700
Class I peroxisomal membrane protein import 19 4.81e-01 7.21e-01 0.15800 1.50e-01 0.049100 2.59e-01 0.71100
Signaling by FGFR4 25 4.81e-01 7.21e-01 0.13700 -1.29e-01 -0.046100 2.64e-01 0.69000
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 4.82e-01 7.21e-01 0.21800 -2.13e-01 -0.047300 2.45e-01 0.79600
RNA Polymerase III Chain Elongation 16 4.82e-01 7.21e-01 0.17700 -5.79e-02 0.167000 6.89e-01 0.24600
Regulation of innate immune responses to cytosolic DNA 12 4.83e-01 7.21e-01 0.19600 -1.08e-01 -0.164000 5.18e-01 0.32600
Signaling by ERBB2 in Cancer 12 4.83e-01 7.21e-01 0.20100 2.69e-03 0.201000 9.87e-01 0.22900
RHO GTPases activate PKNs 24 4.91e-01 7.32e-01 0.13700 9.99e-02 0.093500 3.97e-01 0.42800
ESR-mediated signaling 112 4.97e-01 7.40e-01 0.06580 -6.35e-02 0.017300 2.48e-01 0.75300
Negative regulation of NMDA receptor-mediated neuronal transmission 12 4.99e-01 7.42e-01 0.19300 -1.77e-01 -0.075700 2.88e-01 0.65000
The NLRP3 inflammasome 12 5.02e-01 7.45e-01 0.19100 -1.66e-01 -0.094400 3.19e-01 0.57100
Arachidonic acid metabolism 20 5.02e-01 7.45e-01 0.15100 -1.51e-01 -0.006330 2.43e-01 0.96100
p53-Dependent G1 DNA Damage Response 55 5.04e-01 7.46e-01 0.09010 -8.71e-02 -0.022800 2.65e-01 0.77000
p53-Dependent G1/S DNA damage checkpoint 55 5.04e-01 7.46e-01 0.09010 -8.71e-02 -0.022800 2.65e-01 0.77000
Pre-NOTCH Expression and Processing 41 5.05e-01 7.47e-01 0.10500 1.57e-02 0.103000 8.62e-01 0.25300
Netrin-1 signaling 25 5.07e-01 7.49e-01 0.13500 -8.36e-03 0.135000 9.42e-01 0.24400
Signaling by FGFR1 in disease 25 5.10e-01 7.51e-01 0.13200 1.26e-01 0.039700 2.76e-01 0.73200
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 10 5.10e-01 7.51e-01 0.20800 -1.92e-01 -0.078900 2.93e-01 0.66600
Formation of tubulin folding intermediates by CCT/TriC 14 5.15e-01 7.56e-01 0.18000 -1.76e-01 0.034300 2.54e-01 0.82400
S Phase 138 5.15e-01 7.56e-01 0.05860 4.42e-02 -0.038500 3.72e-01 0.43700
MAPK6/MAPK4 signaling 67 5.20e-01 7.61e-01 0.08140 -8.09e-02 0.008970 2.53e-01 0.89900
DDX58/IFIH1-mediated induction of interferon-alpha/beta 57 5.21e-01 7.61e-01 0.09000 6.43e-02 -0.063000 4.02e-01 0.41200
Potential therapeutics for SARS 60 5.22e-01 7.61e-01 0.08580 -8.51e-02 0.010400 2.55e-01 0.88900
RNA Polymerase III Transcription Initiation 33 5.22e-01 7.61e-01 0.11600 -2.30e-02 0.114000 8.19e-01 0.25900
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 16 5.22e-01 7.61e-01 0.16700 5.12e-02 -0.159000 7.23e-01 0.27100
Non-integrin membrane-ECM interactions 14 5.23e-01 7.61e-01 0.17700 -1.76e-01 0.017500 2.55e-01 0.91000
Metabolism of porphyrins 15 5.24e-01 7.61e-01 0.17200 -1.66e-01 0.043100 2.65e-01 0.77300
Deubiquitination 192 5.24e-01 7.61e-01 0.04910 3.67e-02 -0.032700 3.83e-01 0.43800
Regulation of TP53 Expression and Degradation 33 5.25e-01 7.61e-01 0.11100 -5.79e-02 -0.095200 5.65e-01 0.34400
G1/S DNA Damage Checkpoints 57 5.25e-01 7.61e-01 0.08590 -8.36e-02 -0.019600 2.76e-01 0.79800
Bile acid and bile salt metabolism 14 5.26e-01 7.61e-01 0.17900 1.59e-01 -0.081100 3.02e-01 0.60000
Pre-NOTCH Transcription and Translation 27 5.26e-01 7.61e-01 0.12600 1.25e-01 0.007010 2.60e-01 0.95000
Diseases of mitotic cell cycle 34 5.29e-01 7.65e-01 0.11500 9.67e-02 -0.061500 3.30e-01 0.53500
Diseases of programmed cell death 34 5.30e-01 7.65e-01 0.11500 -8.14e-02 0.081000 4.12e-01 0.41400
B-WICH complex positively regulates rRNA expression 24 5.31e-01 7.65e-01 0.12900 1.08e-01 0.070800 3.59e-01 0.54800
RHOG GTPase cycle 51 5.31e-01 7.65e-01 0.09210 -9.00e-02 0.019700 2.67e-01 0.80900
RHOBTB2 GTPase cycle 19 5.32e-01 7.66e-01 0.15200 1.32e-01 -0.076500 3.21e-01 0.56400
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 5.35e-01 7.68e-01 0.17000 1.57e-01 -0.066100 2.94e-01 0.65800
Transcriptional Regulation by MECP2 31 5.36e-01 7.69e-01 0.11300 -4.85e-02 -0.103000 6.41e-01 0.32400
Translesion synthesis by POLK 15 5.37e-01 7.69e-01 0.17000 -8.75e-02 0.146000 5.58e-01 0.32700
Sulfur amino acid metabolism 15 5.38e-01 7.69e-01 0.16800 -1.64e-01 0.034600 2.71e-01 0.81700
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 22 5.38e-01 7.69e-01 0.14100 -8.74e-02 0.110000 4.79e-01 0.37000
Termination of O-glycan biosynthesis 10 5.41e-01 7.71e-01 0.20100 -1.98e-01 -0.033300 2.79e-01 0.85600
Regulation of insulin secretion 38 5.42e-01 7.73e-01 0.10300 -1.03e-01 -0.009400 2.74e-01 0.92000
Synthesis of PC 19 5.44e-01 7.74e-01 0.14300 6.83e-02 0.125000 6.07e-01 0.34400
Intrinsic Pathway for Apoptosis 46 5.44e-01 7.74e-01 0.09160 -7.49e-02 -0.052700 3.80e-01 0.53700
Cyclin E associated events during G1/S transition 72 5.45e-01 7.74e-01 0.07320 -4.93e-02 -0.054000 4.70e-01 0.42900
Epigenetic regulation of gene expression 72 5.46e-01 7.74e-01 0.07530 7.52e-02 -0.003960 2.71e-01 0.95400
Interleukin-12 family signaling 41 5.46e-01 7.74e-01 0.10000 -2.03e-02 0.098300 8.23e-01 0.27700
Regulation of TP53 Degradation 32 5.47e-01 7.74e-01 0.11000 -4.52e-02 -0.100000 6.59e-01 0.32700
RHOBTB GTPase Cycle 28 5.49e-01 7.75e-01 0.12200 1.13e-01 -0.044700 3.00e-01 0.68200
tRNA modification in the nucleus and cytosol 34 5.49e-01 7.75e-01 0.11100 9.98e-02 -0.048200 3.14e-01 0.62700
Striated Muscle Contraction 10 5.50e-01 7.75e-01 0.19600 -1.78e-01 -0.081600 3.31e-01 0.65500
Protein methylation 12 5.52e-01 7.75e-01 0.18600 -1.55e-01 0.104000 3.53e-01 0.53500
Interleukin-15 signaling 12 5.52e-01 7.75e-01 0.18600 -8.91e-02 0.163000 5.93e-01 0.32800
Death Receptor Signalling 96 5.52e-01 7.75e-01 0.06300 -3.08e-02 -0.055000 6.03e-01 0.35300
RHO GTPase cycle 282 5.52e-01 7.75e-01 0.03710 -3.14e-02 -0.019700 3.68e-01 0.57300
Cyclin A:Cdk2-associated events at S phase entry 74 5.55e-01 7.77e-01 0.07110 -5.13e-02 -0.049300 4.47e-01 0.46400
TRAF6-mediated induction of TAK1 complex within TLR4 complex 10 5.57e-01 7.80e-01 0.19600 -1.95e-01 -0.021900 2.86e-01 0.90500
activated TAK1 mediates p38 MAPK activation 13 5.59e-01 7.82e-01 0.17500 4.78e-02 -0.168000 7.66e-01 0.29300
Aberrant regulation of mitotic cell cycle due to RB1 defects 33 5.63e-01 7.85e-01 0.11100 9.19e-02 -0.061700 3.62e-01 0.54000
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 22 5.63e-01 7.85e-01 0.12900 -1.07e-01 -0.071500 3.86e-01 0.56200
Interleukin-35 Signalling 11 5.63e-01 7.85e-01 0.18300 1.67e-01 0.073100 3.37e-01 0.67500
Transcription of E2F targets under negative control by DREAM complex 18 5.67e-01 7.88e-01 0.14900 1.16e-01 -0.092900 3.92e-01 0.49500
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 61 5.68e-01 7.88e-01 0.07940 7.86e-02 -0.010800 2.89e-01 0.88500
Molecules associated with elastic fibres 12 5.68e-01 7.88e-01 0.17600 -1.17e-02 -0.176000 9.44e-01 0.29100
G alpha (12/13) signalling events 40 5.68e-01 7.88e-01 0.09880 -3.25e-02 0.093300 7.22e-01 0.30800
RHO GTPases Activate ROCKs 13 5.69e-01 7.88e-01 0.17300 6.05e-02 -0.162000 7.06e-01 0.31100
FCGR3A-mediated IL10 synthesis 22 5.72e-01 7.91e-01 0.13300 -1.16e-01 0.065800 3.47e-01 0.59300
Negative regulation of MAPK pathway 36 5.74e-01 7.93e-01 0.09880 -7.69e-02 -0.061900 4.25e-01 0.52100
Signaling by cytosolic FGFR1 fusion mutants 17 5.76e-01 7.95e-01 0.14400 1.30e-01 0.061900 3.54e-01 0.65900
Diseases of DNA repair 10 5.77e-01 7.95e-01 0.19300 1.91e-01 -0.023400 2.95e-01 0.89800
Glycolysis 57 5.78e-01 7.95e-01 0.08250 -6.27e-02 0.053600 4.14e-01 0.48500
Downstream signaling of activated FGFR1 12 5.80e-01 7.95e-01 0.16900 9.45e-02 0.141000 5.71e-01 0.39900
Downstream signaling of activated FGFR2 12 5.80e-01 7.95e-01 0.16900 9.45e-02 0.141000 5.71e-01 0.39900
Downstream signaling of activated FGFR3 12 5.80e-01 7.95e-01 0.16900 9.45e-02 0.141000 5.71e-01 0.39900
Downstream signaling of activated FGFR4 12 5.80e-01 7.95e-01 0.16900 9.45e-02 0.141000 5.71e-01 0.39900
Regulation of IFNG signaling 13 5.81e-01 7.96e-01 0.16400 1.53e-01 0.057300 3.39e-01 0.72100
Glutamate Neurotransmitter Release Cycle 11 5.83e-01 7.97e-01 0.17600 -9.95e-02 -0.145000 5.68e-01 0.40400
G beta:gamma signalling through PI3Kgamma 16 5.84e-01 7.97e-01 0.14700 -1.37e-01 -0.053900 3.44e-01 0.70900
Interleukin-4 and Interleukin-13 signaling 48 5.86e-01 7.98e-01 0.08650 -8.64e-02 0.002430 3.01e-01 0.97700
ECM proteoglycans 12 5.87e-01 7.99e-01 0.16800 1.41e-01 0.091000 3.98e-01 0.58500
Negative epigenetic regulation of rRNA expression 40 5.88e-01 8.00e-01 0.09200 7.99e-02 0.045700 3.82e-01 0.61800
BBSome-mediated cargo-targeting to cilium 19 5.89e-01 8.00e-01 0.14000 9.21e-02 -0.106000 4.87e-01 0.42600
Transport to the Golgi and subsequent modification 127 5.89e-01 8.00e-01 0.05350 -5.27e-02 0.009270 3.07e-01 0.85700
Transcriptional regulation by small RNAs 43 5.91e-01 8.01e-01 0.08990 8.92e-02 0.010600 3.12e-01 0.90400
RND1 GTPase cycle 29 5.92e-01 8.01e-01 0.10800 1.06e-01 0.024800 3.25e-01 0.81800
Resolution of Abasic Sites (AP sites) 30 5.93e-01 8.01e-01 0.10500 -6.00e-02 -0.086400 5.70e-01 0.41300
Signalling to ERKs 26 5.94e-01 8.03e-01 0.11400 -3.73e-02 -0.107000 7.42e-01 0.34400
RHOU GTPase cycle 26 5.95e-01 8.03e-01 0.11300 -5.89e-02 -0.096000 6.03e-01 0.39700
Extension of Telomeres 44 6.00e-01 8.07e-01 0.09000 -3.91e-02 0.081000 6.54e-01 0.35300
TNFR1-induced proapoptotic signaling 11 6.01e-01 8.07e-01 0.17500 -1.89e-02 -0.174000 9.14e-01 0.31900
Listeria monocytogenes entry into host cells 14 6.02e-01 8.07e-01 0.15600 -1.56e-01 0.009750 3.14e-01 0.95000
RNA Polymerase I Transcription Termination 23 6.02e-01 8.07e-01 0.11900 1.12e-01 0.039400 3.51e-01 0.74400
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 16 6.03e-01 8.07e-01 0.14600 1.99e-02 -0.145000 8.91e-01 0.31600
Formation of RNA Pol II elongation complex 48 6.03e-01 8.07e-01 0.08610 -4.56e-02 0.073100 5.85e-01 0.38200
RNA Polymerase II Transcription Elongation 48 6.03e-01 8.07e-01 0.08610 -4.56e-02 0.073100 5.85e-01 0.38200
Termination of translesion DNA synthesis 28 6.03e-01 8.07e-01 0.10700 7.13e-02 0.079600 5.14e-01 0.46600
Estrogen-dependent gene expression 68 6.07e-01 8.11e-01 0.07210 -5.10e-02 0.051100 4.68e-01 0.46700
S33 mutants of beta-catenin aren’t phosphorylated 13 6.13e-01 8.13e-01 0.15400 1.03e-01 0.114000 5.19e-01 0.47500
S37 mutants of beta-catenin aren’t phosphorylated 13 6.13e-01 8.13e-01 0.15400 1.03e-01 0.114000 5.19e-01 0.47500
S45 mutants of beta-catenin aren’t phosphorylated 13 6.13e-01 8.13e-01 0.15400 1.03e-01 0.114000 5.19e-01 0.47500
Signaling by CTNNB1 phospho-site mutants 13 6.13e-01 8.13e-01 0.15400 1.03e-01 0.114000 5.19e-01 0.47500
Signaling by GSK3beta mutants 13 6.13e-01 8.13e-01 0.15400 1.03e-01 0.114000 5.19e-01 0.47500
T41 mutants of beta-catenin aren’t phosphorylated 13 6.13e-01 8.13e-01 0.15400 1.03e-01 0.114000 5.19e-01 0.47500
Processive synthesis on the lagging strand 13 6.17e-01 8.17e-01 0.16100 6.67e-02 -0.146000 6.77e-01 0.36100
Mitochondrial biogenesis 50 6.17e-01 8.17e-01 0.07940 1.68e-02 0.077600 8.37e-01 0.34300
RUNX3 regulates p14-ARF 10 6.20e-01 8.19e-01 0.18200 1.71e-01 -0.062800 3.51e-01 0.73100
RHO GTPase Effectors 183 6.21e-01 8.20e-01 0.04300 3.84e-02 -0.019300 3.73e-01 0.65500
Costimulation by the CD28 family 45 6.22e-01 8.20e-01 0.08200 -6.96e-02 -0.043400 4.20e-01 0.61500
RIP-mediated NFkB activation via ZBP1 14 6.24e-01 8.23e-01 0.14600 -9.84e-02 -0.108000 5.24e-01 0.48600
Aquaporin-mediated transport 22 6.27e-01 8.25e-01 0.12100 -1.15e-01 0.036500 3.50e-01 0.76700
RNA Polymerase III Transcription Initiation From Type 3 Promoter 25 6.29e-01 8.25e-01 0.10900 4.00e-02 0.102000 7.29e-01 0.37900
RAB GEFs exchange GTP for GDP on RABs 61 6.29e-01 8.25e-01 0.06970 -6.03e-02 -0.035000 4.16e-01 0.63700
FLT3 signaling in disease 25 6.31e-01 8.27e-01 0.11200 -1.10e-01 0.020200 3.41e-01 0.86200
Transcriptional regulation of white adipocyte differentiation 55 6.32e-01 8.28e-01 0.07290 3.76e-02 0.062500 6.30e-01 0.42300
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 6.33e-01 8.28e-01 0.15700 -1.32e-01 0.084600 4.09e-01 0.59800
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 34 6.35e-01 8.30e-01 0.09440 8.55e-04 0.094400 9.93e-01 0.34200
Cytosolic sensors of pathogen-associated DNA 51 6.37e-01 8.31e-01 0.07890 -6.73e-02 0.041200 4.07e-01 0.61200
Interleukin-6 family signaling 12 6.39e-01 8.34e-01 0.16100 -6.69e-02 0.146000 6.88e-01 0.38000
Apoptotic cleavage of cellular proteins 25 6.42e-01 8.34e-01 0.10800 1.08e-01 0.004910 3.49e-01 0.96600
Base Excision Repair 36 6.42e-01 8.34e-01 0.08860 -7.70e-02 -0.043800 4.25e-01 0.65000
Oncogenic MAPK signaling 56 6.42e-01 8.34e-01 0.07170 -1.97e-02 -0.068900 7.99e-01 0.37300
Dual incision in TC-NER 55 6.43e-01 8.34e-01 0.07420 -7.26e-02 0.015400 3.53e-01 0.84400
Nuclear Envelope (NE) Reassembly 60 6.44e-01 8.34e-01 0.07080 6.95e-02 -0.013900 3.53e-01 0.85200
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 6.45e-01 8.34e-01 0.13700 1.32e-01 -0.037500 3.61e-01 0.79500
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 6.45e-01 8.34e-01 0.13700 1.32e-01 -0.037500 3.61e-01 0.79500
G-protein beta:gamma signalling 20 6.46e-01 8.35e-01 0.12200 -1.19e-01 0.029300 3.59e-01 0.82100
Glyoxylate metabolism and glycine degradation 19 6.47e-01 8.35e-01 0.12300 1.23e-01 0.008970 3.55e-01 0.94600
Chromatin modifying enzymes 150 6.50e-01 8.36e-01 0.04470 -4.31e-02 0.011900 3.65e-01 0.80300
Chromatin organization 150 6.50e-01 8.36e-01 0.04470 -4.31e-02 0.011900 3.65e-01 0.80300
NOTCH4 Intracellular Domain Regulates Transcription 14 6.53e-01 8.36e-01 0.13900 -1.19e-01 -0.071200 4.40e-01 0.64500
Vasopressin regulates renal water homeostasis via Aquaporins 21 6.54e-01 8.36e-01 0.11800 -1.13e-01 0.032800 3.70e-01 0.79500
RHOBTB1 GTPase cycle 18 6.55e-01 8.36e-01 0.12700 1.24e-01 -0.025300 3.63e-01 0.85300
Transcriptional regulation of granulopoiesis 24 6.55e-01 8.36e-01 0.10900 1.09e-01 -0.002840 3.58e-01 0.98100
Activation of BAD and translocation to mitochondria 14 6.55e-01 8.36e-01 0.14100 -1.40e-01 -0.017300 3.65e-01 0.91100
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 13 6.58e-01 8.36e-01 0.14600 -5.67e-03 -0.146000 9.72e-01 0.36200
PRC2 methylates histones and DNA 11 6.59e-01 8.36e-01 0.15500 1.40e-01 0.067900 4.22e-01 0.69700
Intra-Golgi and retrograde Golgi-to-ER traffic 155 6.60e-01 8.36e-01 0.04300 -7.49e-03 0.042300 8.73e-01 0.36500
RAS processing 15 6.60e-01 8.36e-01 0.13300 -1.20e-01 -0.057100 4.21e-01 0.70200
FGFR1 mutant receptor activation 20 6.62e-01 8.36e-01 0.11400 6.42e-02 0.094600 6.20e-01 0.46400
APC truncation mutants have impaired AXIN binding 12 6.62e-01 8.36e-01 0.14800 1.29e-01 0.071300 4.38e-01 0.66900
AXIN missense mutants destabilize the destruction complex 12 6.62e-01 8.36e-01 0.14800 1.29e-01 0.071300 4.38e-01 0.66900
Signaling by AMER1 mutants 12 6.62e-01 8.36e-01 0.14800 1.29e-01 0.071300 4.38e-01 0.66900
Signaling by APC mutants 12 6.62e-01 8.36e-01 0.14800 1.29e-01 0.071300 4.38e-01 0.66900
Signaling by AXIN mutants 12 6.62e-01 8.36e-01 0.14800 1.29e-01 0.071300 4.38e-01 0.66900
Truncations of AMER1 destabilize the destruction complex 12 6.62e-01 8.36e-01 0.14800 1.29e-01 0.071300 4.38e-01 0.66900
Cleavage of the damaged pyrimidine 12 6.63e-01 8.36e-01 0.14800 -4.95e-02 -0.140000 7.67e-01 0.40100
Depyrimidination 12 6.63e-01 8.36e-01 0.14800 -4.95e-02 -0.140000 7.67e-01 0.40100
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 12 6.63e-01 8.36e-01 0.14800 -4.95e-02 -0.140000 7.67e-01 0.40100
RUNX2 regulates bone development 17 6.65e-01 8.38e-01 0.12500 -2.48e-02 -0.123000 8.59e-01 0.38200
FOXO-mediated transcription 46 6.67e-01 8.39e-01 0.07550 -7.17e-02 -0.023800 4.01e-01 0.78000
Activation of kainate receptors upon glutamate binding 16 6.68e-01 8.40e-01 0.13100 -3.37e-02 0.127000 8.16e-01 0.38000
Signaling by FGFR2 in disease 23 6.68e-01 8.40e-01 0.11100 -9.62e-02 0.054700 4.25e-01 0.65000
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 22 6.70e-01 8.40e-01 0.11200 -1.05e-01 0.038300 3.92e-01 0.75600
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 434 6.71e-01 8.41e-01 0.02530 7.26e-05 -0.025300 9.98e-01 0.37200
Interleukin-6 signaling 10 6.72e-01 8.41e-01 0.16100 2.82e-02 0.159000 8.77e-01 0.38500
Long-term potentiation 11 6.73e-01 8.41e-01 0.15500 -1.55e-01 -0.000996 3.74e-01 0.99500
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 6.73e-01 8.41e-01 0.12400 6.32e-02 -0.107000 6.43e-01 0.43400
RHOF GTPase cycle 25 6.73e-01 8.41e-01 0.10000 7.43e-02 0.066900 5.20e-01 0.56300
Removal of the Flap Intermediate 12 6.77e-01 8.44e-01 0.15100 8.66e-02 -0.124000 6.04e-01 0.45800
Transcriptional activation of mitochondrial biogenesis 36 6.79e-01 8.46e-01 0.08320 2.99e-02 0.077600 7.56e-01 0.42100
CD209 (DC-SIGN) signaling 15 6.81e-01 8.48e-01 0.13400 -1.18e-01 0.062800 4.29e-01 0.67400
Cytochrome c-mediated apoptotic response 10 6.83e-01 8.48e-01 0.16300 8.88e-02 -0.137000 6.27e-01 0.45300
Elastic fibre formation 17 6.84e-01 8.48e-01 0.12200 -1.22e-01 0.003120 3.83e-01 0.98200
Signaling by FGFR1 28 6.84e-01 8.48e-01 0.09420 -9.29e-02 -0.015700 3.95e-01 0.88500
Myogenesis 13 6.85e-01 8.48e-01 0.14200 4.97e-02 -0.133000 7.56e-01 0.40700
Processing of Capped Intron-Containing Pre-mRNA 191 6.86e-01 8.48e-01 0.03750 -3.19e-02 0.019800 4.50e-01 0.63900
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 6.87e-01 8.48e-01 0.13800 -1.04e-01 0.090300 5.02e-01 0.55900
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 6.87e-01 8.48e-01 0.13800 -1.04e-01 0.090300 5.02e-01 0.55900
Polymerase switching on the C-strand of the telomere 22 6.89e-01 8.50e-01 0.10900 -9.24e-02 0.057600 4.53e-01 0.64000
HIV Life Cycle 127 6.92e-01 8.51e-01 0.04390 5.78e-03 0.043500 9.11e-01 0.39900
G-protein activation 12 6.92e-01 8.51e-01 0.14300 -9.20e-03 0.143000 9.56e-01 0.39100
PERK regulates gene expression 26 6.94e-01 8.51e-01 0.09620 9.55e-02 0.011700 4.00e-01 0.91800
Citric acid cycle (TCA cycle) 19 6.95e-01 8.51e-01 0.11600 -9.72e-02 0.063200 4.63e-01 0.63400
APC/C-mediated degradation of cell cycle proteins 77 6.96e-01 8.51e-01 0.05530 -1.83e-02 -0.052100 7.82e-01 0.43000
Regulation of mitotic cell cycle 77 6.96e-01 8.51e-01 0.05530 -1.83e-02 -0.052100 7.82e-01 0.43000
TP53 Regulates Transcription of Cell Death Genes 30 6.96e-01 8.51e-01 0.09220 5.78e-02 -0.071900 5.84e-01 0.49600
Deadenylation-dependent mRNA decay 50 6.97e-01 8.51e-01 0.07130 6.14e-02 -0.036200 4.53e-01 0.65800
Cell recruitment (pro-inflammatory response) 15 6.98e-01 8.51e-01 0.12400 -4.74e-02 -0.115000 7.51e-01 0.44300
Purinergic signaling in leishmaniasis infection 15 6.98e-01 8.51e-01 0.12400 -4.74e-02 -0.115000 7.51e-01 0.44300
Base-Excision Repair, AP Site Formation 13 6.99e-01 8.51e-01 0.13200 -6.68e-02 -0.114000 6.77e-01 0.47600
RAC3 GTPase cycle 59 6.99e-01 8.51e-01 0.06440 -6.33e-02 0.011800 4.01e-01 0.87500
Intraflagellar transport 31 7.04e-01 8.57e-01 0.08490 4.19e-02 0.073900 6.86e-01 0.47700
NoRC negatively regulates rRNA expression 39 7.05e-01 8.57e-01 0.07590 6.96e-02 0.030100 4.52e-01 0.74500
Metabolism of nitric oxide: NOS3 activation and regulation 11 7.06e-01 8.57e-01 0.14600 -8.14e-03 0.145000 9.63e-01 0.40400
Regulation of KIT signaling 11 7.06e-01 8.57e-01 0.14400 -1.44e-01 -0.011000 4.08e-01 0.94900
Neurotransmitter release cycle 19 7.08e-01 8.58e-01 0.11300 -6.43e-02 0.092800 6.28e-01 0.48400
Energy dependent regulation of mTOR by LKB1-AMPK 26 7.14e-01 8.64e-01 0.09430 -2.27e-02 0.091500 8.42e-01 0.42000
Signaling by NTRK2 (TRKB) 16 7.14e-01 8.64e-01 0.11700 2.30e-02 0.115000 8.74e-01 0.42700
Class I MHC mediated antigen processing & presentation 282 7.16e-01 8.66e-01 0.02820 2.75e-02 0.005970 4.31e-01 0.86400
Interleukin receptor SHC signaling 16 7.21e-01 8.68e-01 0.11900 -1.04e-01 0.058300 4.71e-01 0.68600
RORA activates gene expression 10 7.21e-01 8.68e-01 0.14500 4.95e-02 0.136000 7.86e-01 0.45600
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 14 7.22e-01 8.68e-01 0.12500 -1.25e-01 0.004940 4.20e-01 0.97400
RHOJ GTPase cycle 36 7.22e-01 8.68e-01 0.07940 -3.48e-02 0.071400 7.18e-01 0.45900
Integrin cell surface interactions 25 7.23e-01 8.68e-01 0.09270 -9.25e-02 -0.005770 4.24e-01 0.96000
Diseases associated with N-glycosylation of proteins 15 7.23e-01 8.68e-01 0.12200 3.49e-02 -0.117000 8.15e-01 0.43400
Heme biosynthesis 10 7.23e-01 8.68e-01 0.15100 -1.21e-01 0.090600 5.09e-01 0.62000
DNA strand elongation 27 7.25e-01 8.68e-01 0.08850 8.80e-02 0.009440 4.29e-01 0.93200
Inflammasomes 16 7.25e-01 8.68e-01 0.11400 -3.90e-02 -0.107000 7.87e-01 0.46000
Extra-nuclear estrogen signaling 48 7.26e-01 8.68e-01 0.06620 -6.52e-02 -0.011400 4.35e-01 0.89200
HATs acetylate histones 58 7.28e-01 8.70e-01 0.06160 -5.79e-02 0.021100 4.46e-01 0.78200
Depolymerisation of the Nuclear Lamina 13 7.30e-01 8.70e-01 0.12400 8.38e-02 0.090900 6.01e-01 0.57100
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 7.31e-01 8.70e-01 0.13000 -3.54e-02 -0.125000 8.32e-01 0.45300
Signaling by FGFR3 26 7.31e-01 8.70e-01 0.08910 -8.85e-02 -0.010000 4.35e-01 0.93000
Retrograde transport at the Trans-Golgi-Network 45 7.31e-01 8.70e-01 0.06970 6.23e-02 -0.031200 4.70e-01 0.71800
PPARA activates gene expression 79 7.35e-01 8.72e-01 0.04990 2.98e-02 0.040000 6.47e-01 0.54000
Interleukin-10 signaling 13 7.35e-01 8.72e-01 0.12200 -9.94e-02 -0.071600 5.35e-01 0.65500
RNA Polymerase II Pre-transcription Events 65 7.35e-01 8.72e-01 0.05500 4.87e-02 0.025700 4.98e-01 0.72100
Unwinding of DNA 10 7.36e-01 8.72e-01 0.13900 9.27e-02 0.104000 6.12e-01 0.57000
Rap1 signalling 10 7.38e-01 8.74e-01 0.13800 9.09e-02 0.104000 6.19e-01 0.56800
G beta:gamma signalling through PLC beta 12 7.42e-01 8.76e-01 0.13100 -4.31e-02 0.124000 7.96e-01 0.45900
Presynaptic function of Kainate receptors 12 7.42e-01 8.76e-01 0.13100 -4.31e-02 0.124000 7.96e-01 0.45900
Orc1 removal from chromatin 61 7.42e-01 8.76e-01 0.05580 -4.61e-02 -0.031400 5.34e-01 0.67200
Transcriptional Regulation by TP53 295 7.47e-01 8.76e-01 0.02680 2.04e-02 -0.017400 5.51e-01 0.61100
Interleukin-20 family signaling 13 7.50e-01 8.76e-01 0.12400 5.76e-02 -0.110000 7.19e-01 0.49200
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 7.50e-01 8.76e-01 0.13600 -8.86e-02 0.103000 6.11e-01 0.55500
Signaling by KIT in disease 17 7.51e-01 8.76e-01 0.10900 7.59e-02 -0.078300 5.88e-01 0.57700
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 17 7.51e-01 8.76e-01 0.10900 7.59e-02 -0.078300 5.88e-01 0.57700
Viral Messenger RNA Synthesis 40 7.52e-01 8.76e-01 0.06730 5.48e-02 0.039000 5.49e-01 0.67000
Regulation of HSF1-mediated heat shock response 66 7.52e-01 8.76e-01 0.05340 5.30e-02 0.006560 4.58e-01 0.92700
Endosomal/Vacuolar pathway 11 7.53e-01 8.76e-01 0.13200 -1.31e-01 0.021400 4.54e-01 0.90200
Integrin signaling 17 7.54e-01 8.76e-01 0.10200 -8.42e-02 -0.058400 5.48e-01 0.67700
Platelet Aggregation (Plug Formation) 17 7.54e-01 8.76e-01 0.10200 -8.42e-02 -0.058400 5.48e-01 0.67700
Glucagon signaling in metabolic regulation 17 7.55e-01 8.76e-01 0.10800 -9.04e-02 0.058500 5.19e-01 0.67600
Signaling by Rho GTPases 422 7.56e-01 8.76e-01 0.02170 3.93e-03 -0.021400 8.91e-01 0.45800
HIV Transcription Initiation 37 7.56e-01 8.76e-01 0.07210 6.90e-02 -0.021000 4.68e-01 0.82600
RNA Polymerase II HIV Promoter Escape 37 7.56e-01 8.76e-01 0.07210 6.90e-02 -0.021000 4.68e-01 0.82600
RNA Polymerase II Promoter Escape 37 7.56e-01 8.76e-01 0.07210 6.90e-02 -0.021000 4.68e-01 0.82600
RNA Polymerase II Transcription Initiation 37 7.56e-01 8.76e-01 0.07210 6.90e-02 -0.021000 4.68e-01 0.82600
RNA Polymerase II Transcription Initiation And Promoter Clearance 37 7.56e-01 8.76e-01 0.07210 6.90e-02 -0.021000 4.68e-01 0.82600
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 37 7.56e-01 8.76e-01 0.07210 6.90e-02 -0.021000 4.68e-01 0.82600
Synthesis of PIPs at the plasma membrane 36 7.57e-01 8.77e-01 0.07130 -7.06e-02 -0.009990 4.64e-01 0.91700
Transcriptional Regulation by VENTX 30 7.58e-01 8.77e-01 0.08040 7.11e-02 -0.037400 5.00e-01 0.72300
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 18 7.61e-01 8.77e-01 0.10200 -9.99e-02 0.019200 4.64e-01 0.88800
ZBP1(DAI) mediated induction of type I IFNs 17 7.62e-01 8.77e-01 0.10100 -8.97e-02 -0.046400 5.22e-01 0.74100
Chromosome Maintenance 74 7.62e-01 8.77e-01 0.04900 1.28e-02 0.047300 8.50e-01 0.48300
TICAM1, RIP1-mediated IKK complex recruitment 17 7.62e-01 8.77e-01 0.10600 6.86e-02 -0.080900 6.24e-01 0.56400
Post-chaperonin tubulin folding pathway 13 7.63e-01 8.77e-01 0.11500 -8.88e-02 -0.072600 5.80e-01 0.65000
Diseases associated with glycosylation precursor biosynthesis 18 7.63e-01 8.77e-01 0.10300 -5.57e-02 0.086100 6.83e-01 0.52700
Diseases associated with O-glycosylation of proteins 21 7.63e-01 8.77e-01 0.09220 -6.48e-03 -0.092000 9.59e-01 0.46600
Mitochondrial iron-sulfur cluster biogenesis 10 7.66e-01 8.79e-01 0.13600 5.56e-02 -0.124000 7.61e-01 0.49700
RNA Pol II CTD phosphorylation and interaction with CE 23 7.74e-01 8.86e-01 0.08780 -8.17e-02 0.032100 4.98e-01 0.79000
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 23 7.74e-01 8.86e-01 0.08780 -8.17e-02 0.032100 4.98e-01 0.79000
Triglyceride catabolism 11 7.75e-01 8.86e-01 0.12100 8.71e-02 0.084100 6.17e-01 0.62900
RUNX3 regulates NOTCH signaling 11 7.76e-01 8.87e-01 0.12700 -1.09e-01 0.065600 5.32e-01 0.70700
Protein ubiquitination 59 7.78e-01 8.88e-01 0.05290 -5.23e-02 -0.008220 4.88e-01 0.91300
DNA Replication 110 7.78e-01 8.88e-01 0.04030 3.10e-02 -0.025700 5.76e-01 0.64200
Signaling by NTRK3 (TRKC) 12 7.80e-01 8.88e-01 0.11800 -1.17e-01 0.011500 4.81e-01 0.94500
KSRP (KHSRP) binds and destabilizes mRNA 15 7.80e-01 8.88e-01 0.10300 -4.28e-02 -0.093500 7.74e-01 0.53100
Global Genome Nucleotide Excision Repair (GG-NER) 76 7.86e-01 8.93e-01 0.04740 -2.96e-02 0.037100 6.57e-01 0.57700
Thromboxane signalling through TP receptor 14 7.86e-01 8.93e-01 0.11000 -6.97e-02 0.085100 6.52e-01 0.58100
G beta:gamma signalling through BTK 10 7.87e-01 8.93e-01 0.12300 7.25e-02 0.099200 6.91e-01 0.58700
TICAM1-dependent activation of IRF3/IRF7 12 7.88e-01 8.93e-01 0.11800 -9.71e-02 0.067200 5.60e-01 0.68700
Association of TriC/CCT with target proteins during biosynthesis 29 7.89e-01 8.93e-01 0.07550 -6.84e-02 0.031900 5.24e-01 0.76600
Negative regulation of MET activity 16 7.89e-01 8.93e-01 0.09890 -9.87e-02 -0.006230 4.95e-01 0.96600
Regulation of MECP2 expression and activity 23 7.90e-01 8.93e-01 0.08300 8.89e-03 -0.082600 9.41e-01 0.49300
ADP signalling through P2Y purinoceptor 1 15 7.91e-01 8.93e-01 0.10200 -7.15e-03 0.102000 9.62e-01 0.49400
Metabolic disorders of biological oxidation enzymes 14 7.91e-01 8.93e-01 0.10800 9.51e-02 -0.051300 5.38e-01 0.74000
Telomere C-strand (Lagging Strand) Synthesis 29 7.92e-01 8.93e-01 0.07510 -3.84e-02 0.064500 7.21e-01 0.54800
TRAF6 mediated NF-kB activation 18 7.92e-01 8.93e-01 0.09530 -5.36e-02 0.078700 6.94e-01 0.56300
Lagging Strand Synthesis 17 7.96e-01 8.94e-01 0.09680 8.51e-02 -0.046100 5.44e-01 0.74200
Metabolism of folate and pterines 11 7.96e-01 8.94e-01 0.11800 1.18e-01 -0.010600 5.00e-01 0.95100
Transcriptional regulation by RUNX1 133 7.98e-01 8.94e-01 0.03300 -2.64e-02 -0.019800 6.01e-01 0.69400
Activation of HOX genes during differentiation 38 7.99e-01 8.94e-01 0.06270 1.70e-03 0.062700 9.86e-01 0.50400
Activation of anterior HOX genes in hindbrain development during early embryogenesis 38 7.99e-01 8.94e-01 0.06270 1.70e-03 0.062700 9.86e-01 0.50400
GABA receptor activation 18 7.99e-01 8.94e-01 0.09340 -4.67e-02 0.080900 7.31e-01 0.55300
Caspase-mediated cleavage of cytoskeletal proteins 10 7.99e-01 8.94e-01 0.11900 -7.82e-02 -0.089700 6.69e-01 0.62400
Cytokine Signaling in Immune system 424 8.00e-01 8.94e-01 0.01970 1.11e-02 -0.016200 6.98e-01 0.57300
TP53 Regulates Transcription of DNA Repair Genes 51 8.03e-01 8.96e-01 0.05510 -3.38e-02 0.043600 6.77e-01 0.59100
Leading Strand Synthesis 12 8.04e-01 8.96e-01 0.11300 9.94e-02 -0.053000 5.51e-01 0.75100
Polymerase switching 12 8.04e-01 8.96e-01 0.11300 9.94e-02 -0.053000 5.51e-01 0.75100
Effects of PIP2 hydrolysis 19 8.06e-01 8.97e-01 0.08790 -1.44e-02 0.086700 9.14e-01 0.51300
Retinoid metabolism and transport 10 8.10e-01 9.02e-01 0.12100 -1.02e-01 0.065300 5.76e-01 0.72100
Sema4D induced cell migration and growth-cone collapse 12 8.13e-01 9.02e-01 0.10400 -7.39e-02 -0.073500 6.58e-01 0.66000
Biological oxidations 77 8.14e-01 9.02e-01 0.04240 -1.58e-03 0.042400 9.81e-01 0.52100
SLC transporter disorders 49 8.14e-01 9.02e-01 0.05420 2.54e-02 -0.047900 7.59e-01 0.56200
Activation of G protein gated Potassium channels 11 8.16e-01 9.02e-01 0.11000 1.06e-01 0.027500 5.43e-01 0.87500
G protein gated Potassium channels 11 8.16e-01 9.02e-01 0.11000 1.06e-01 0.027500 5.43e-01 0.87500
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 11 8.16e-01 9.02e-01 0.11000 1.06e-01 0.027500 5.43e-01 0.87500
Phase I - Functionalization of compounds 30 8.20e-01 9.06e-01 0.06650 4.74e-04 0.066500 9.96e-01 0.52900
Vitamin B5 (pantothenate) metabolism 11 8.23e-01 9.09e-01 0.11000 1.06e-01 -0.028900 5.42e-01 0.86800
RNA Polymerase I Transcription Initiation 38 8.25e-01 9.09e-01 0.05730 1.82e-02 0.054300 8.46e-01 0.56300
Signal amplification 19 8.25e-01 9.09e-01 0.08400 -7.57e-02 0.036500 5.68e-01 0.78300
O-linked glycosylation of mucins 26 8.27e-01 9.10e-01 0.07080 -6.85e-02 0.018000 5.46e-01 0.87400
Signalling to RAS 13 8.28e-01 9.10e-01 0.09660 -3.30e-02 -0.090800 8.37e-01 0.57100
Removal of the Flap Intermediate from the C-strand 15 8.29e-01 9.10e-01 0.09360 -7.63e-02 0.054300 6.09e-01 0.71600
Switching of origins to a post-replicative state 79 8.30e-01 9.10e-01 0.03880 -2.46e-02 -0.029900 7.06e-01 0.64700
Activation of GABAB receptors 17 8.30e-01 9.10e-01 0.08760 -4.60e-02 0.074500 7.43e-01 0.59500
GABA B receptor activation 17 8.30e-01 9.10e-01 0.08760 -4.60e-02 0.074500 7.43e-01 0.59500
HSP90 chaperone cycle for steroid hormone receptors (SHR) 32 8.32e-01 9.10e-01 0.06030 -4.77e-02 -0.036900 6.41e-01 0.71800
ATF4 activates genes in response to endoplasmic reticulum stress 23 8.32e-01 9.10e-01 0.07410 7.10e-02 -0.021000 5.56e-01 0.86200
Synthesis of very long-chain fatty acyl-CoAs 16 8.35e-01 9.13e-01 0.08640 3.29e-03 0.086400 9.82e-01 0.55000
RNA Polymerase III Abortive And Retractive Initiation 37 8.40e-01 9.16e-01 0.05510 1.83e-02 0.052000 8.47e-01 0.58500
RNA Polymerase III Transcription 37 8.40e-01 9.16e-01 0.05510 1.83e-02 0.052000 8.47e-01 0.58500
Late Phase of HIV Life Cycle 115 8.42e-01 9.18e-01 0.03090 1.90e-02 0.024300 7.25e-01 0.65300
mRNA decay by 3’ to 5’ exoribonuclease 14 8.45e-01 9.19e-01 0.08770 -4.06e-02 -0.077700 7.92e-01 0.61500
Recognition of DNA damage by PCNA-containing replication complex 26 8.46e-01 9.20e-01 0.06670 -6.32e-02 0.021500 5.78e-01 0.84900
Visual phototransduction 31 8.48e-01 9.21e-01 0.05940 4.24e-03 0.059200 9.67e-01 0.56900
Ras activation upon Ca2+ influx through NMDA receptor 10 8.51e-01 9.24e-01 0.10100 -4.55e-02 -0.090500 8.03e-01 0.62000
NOTCH3 Intracellular Domain Regulates Transcription 15 8.53e-01 9.24e-01 0.08270 -7.79e-02 -0.027700 6.01e-01 0.85300
Inwardly rectifying K+ channels 12 8.53e-01 9.24e-01 0.09620 8.20e-02 -0.050300 6.23e-01 0.76300
Unfolded Protein Response (UPR) 70 8.54e-01 9.24e-01 0.03990 -2.33e-02 0.032400 7.36e-01 0.64000
VEGFR2 mediated cell proliferation 16 8.57e-01 9.27e-01 0.07990 -7.98e-02 -0.004120 5.81e-01 0.97700
COPI-mediated anterograde transport 68 8.58e-01 9.28e-01 0.03780 -2.99e-02 -0.023100 6.71e-01 0.74200
Glucagon-type ligand receptors 13 8.65e-01 9.33e-01 0.08490 -2.91e-02 -0.079700 8.56e-01 0.61900
DARPP-32 events 20 8.66e-01 9.33e-01 0.06990 1.06e-02 -0.069100 9.34e-01 0.59300
Miscellaneous transport and binding events 14 8.67e-01 9.33e-01 0.08210 8.17e-02 0.007520 5.97e-01 0.96100
Positive epigenetic regulation of rRNA expression 37 8.68e-01 9.33e-01 0.04930 3.74e-02 0.032100 6.94e-01 0.73600
Antigen processing: Ubiquitination & Proteasome degradation 236 8.68e-01 9.33e-01 0.02010 2.00e-02 0.001890 5.98e-01 0.96100
Sialic acid metabolism 23 8.69e-01 9.33e-01 0.06210 -4.81e-02 -0.039300 6.90e-01 0.74400
Regulation of lipid metabolism by PPARalpha 81 8.69e-01 9.33e-01 0.03320 2.48e-02 0.022100 7.01e-01 0.73200
Methylation 10 8.72e-01 9.35e-01 0.09600 -9.57e-02 0.008740 6.01e-01 0.96200
Signaling by FGFR in disease 39 8.74e-01 9.37e-01 0.04780 3.88e-03 0.047600 9.67e-01 0.60700
Metal ion SLC transporters 15 8.78e-01 9.40e-01 0.07430 -3.96e-02 -0.062800 7.91e-01 0.67400
IKK complex recruitment mediated by RIP1 17 8.84e-01 9.44e-01 0.07120 3.22e-02 -0.063500 8.18e-01 0.65100
DNA Replication Pre-Initiation 72 8.84e-01 9.44e-01 0.03300 -2.56e-02 -0.020700 7.08e-01 0.76200
Processive synthesis on the C-strand of the telomere 17 8.84e-01 9.44e-01 0.07070 -6.60e-02 0.025200 6.38e-01 0.85700
Platelet sensitization by LDL 13 8.89e-01 9.48e-01 0.07850 7.66e-02 -0.017000 6.32e-01 0.91500
Post-translational protein modification 890 8.90e-01 9.48e-01 0.00954 6.79e-03 0.006710 7.39e-01 0.74200
PI Metabolism 59 8.91e-01 9.48e-01 0.03670 -3.57e-02 0.008770 6.36e-01 0.90700
Mismatch Repair 13 8.91e-01 9.48e-01 0.07730 5.92e-03 -0.077100 9.71e-01 0.63000
Neddylation 179 8.93e-01 9.49e-01 0.02120 -1.92e-02 0.009060 6.60e-01 0.83500
Sema4D in semaphorin signaling 15 8.94e-01 9.49e-01 0.07230 -6.20e-02 0.037300 6.78e-01 0.80300
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 12 8.95e-01 9.49e-01 0.07820 7.80e-02 0.004980 6.40e-01 0.97600
E3 ubiquitin ligases ubiquitinate target proteins 41 8.97e-01 9.50e-01 0.04230 -4.19e-02 0.006220 6.43e-01 0.94500
STING mediated induction of host immune responses 10 8.98e-01 9.50e-01 0.08700 -6.46e-02 0.058300 7.24e-01 0.75000
Synthesis of PA 18 8.98e-01 9.50e-01 0.06130 4.23e-02 0.044400 7.56e-01 0.74500
Signaling by FLT3 ITD and TKD mutants 13 8.99e-01 9.50e-01 0.07540 -6.93e-02 0.029900 6.66e-01 0.85200
mRNA Capping 25 9.01e-01 9.52e-01 0.05280 -3.04e-03 0.052700 9.79e-01 0.64800
Metalloprotease DUBs 16 9.03e-01 9.53e-01 0.06600 6.38e-02 -0.016900 6.59e-01 0.90700
Ovarian tumor domain proteases 28 9.04e-01 9.53e-01 0.04980 -4.72e-02 0.015800 6.66e-01 0.88500
Cargo concentration in the ER 20 9.04e-01 9.53e-01 0.05630 4.20e-02 0.037500 7.45e-01 0.77100
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 9.08e-01 9.54e-01 0.07540 5.42e-02 -0.052400 7.45e-01 0.75300
HCMV Late Events 51 9.09e-01 9.54e-01 0.03640 -2.72e-02 0.024200 7.37e-01 0.76600
PCNA-Dependent Long Patch Base Excision Repair 18 9.09e-01 9.54e-01 0.06100 -5.03e-02 0.034500 7.12e-01 0.80000
Adrenaline,noradrenaline inhibits insulin secretion 14 9.10e-01 9.54e-01 0.06840 -6.38e-02 0.024700 6.79e-01 0.87300
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 21 9.10e-01 9.54e-01 0.05610 2.56e-02 -0.049900 8.39e-01 0.69200
Signaling by PDGF 25 9.15e-01 9.57e-01 0.05010 -3.27e-02 0.038000 7.78e-01 0.74300
Diseases associated with the TLR signaling cascade 16 9.15e-01 9.57e-01 0.05950 -2.83e-02 -0.052400 8.45e-01 0.71700
Diseases of Immune System 16 9.15e-01 9.57e-01 0.05950 -2.83e-02 -0.052400 8.45e-01 0.71700
Transcription of the HIV genome 55 9.17e-01 9.58e-01 0.03210 3.15e-02 0.006020 6.87e-01 0.93900
ER to Golgi Anterograde Transport 105 9.18e-01 9.58e-01 0.02350 -2.33e-02 0.003320 6.81e-01 0.95300
Glutathione conjugation 20 9.19e-01 9.58e-01 0.05460 4.53e-02 -0.030400 7.26e-01 0.81400
COPI-independent Golgi-to-ER retrograde traffic 28 9.21e-01 9.60e-01 0.04310 -3.09e-02 -0.030000 7.77e-01 0.78400
RAC1 GTPase cycle 109 9.23e-01 9.60e-01 0.02170 -1.47e-02 -0.015900 7.91e-01 0.77500
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 34 9.23e-01 9.60e-01 0.04050 -1.96e-02 0.035400 8.43e-01 0.72100
Voltage gated Potassium channels 10 9.24e-01 9.60e-01 0.07380 -6.83e-02 0.027900 7.08e-01 0.87900
RNA Polymerase III Transcription Termination 20 9.25e-01 9.60e-01 0.04980 2.54e-02 0.042800 8.44e-01 0.74000
FOXO-mediated transcription of cell cycle genes 13 9.26e-01 9.60e-01 0.06380 1.81e-02 -0.061200 9.10e-01 0.70300
Nucleobase catabolism 21 9.26e-01 9.60e-01 0.04870 1.09e-02 0.047500 9.31e-01 0.70600
Frs2-mediated activation 11 9.28e-01 9.61e-01 0.06550 -4.63e-02 -0.046300 7.90e-01 0.79100
Synthesis of DNA 103 9.30e-01 9.62e-01 0.02200 4.03e-03 -0.021700 9.44e-01 0.70500
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 20 9.30e-01 9.62e-01 0.04820 -1.74e-02 -0.044900 8.93e-01 0.72800
ADP signalling through P2Y purinoceptor 12 12 9.33e-01 9.63e-01 0.06070 2.18e-02 0.056700 8.96e-01 0.73400
Synthesis of PIPs at the Golgi membrane 12 9.34e-01 9.63e-01 0.06320 -5.58e-02 0.029600 7.38e-01 0.85900
Pyruvate metabolism 20 9.40e-01 9.69e-01 0.04480 1.17e-02 0.043200 9.28e-01 0.73800
Interleukin-37 signaling 17 9.41e-01 9.70e-01 0.04750 -3.82e-02 -0.028100 7.85e-01 0.84100
Synthesis of substrates in N-glycan biosythesis 48 9.43e-01 9.70e-01 0.02790 1.95e-02 0.020000 8.15e-01 0.81100
Signaling by FLT3 fusion proteins 17 9.44e-01 9.70e-01 0.04710 4.61e-02 0.009940 7.43e-01 0.94300
EGR2 and SOX10-mediated initiation of Schwann cell myelination 13 9.46e-01 9.72e-01 0.05490 3.61e-02 -0.041500 8.22e-01 0.79600
Intra-Golgi traffic 39 9.48e-01 9.73e-01 0.03000 4.36e-03 0.029700 9.62e-01 0.74900
Phase II - Conjugation of compounds 44 9.50e-01 9.74e-01 0.02770 2.69e-02 0.006350 7.58e-01 0.94200
Growth hormone receptor signaling 17 9.54e-01 9.77e-01 0.04230 -3.89e-02 -0.016500 7.81e-01 0.90600
Interleukin-2 family signaling 29 9.54e-01 9.77e-01 0.03290 -3.28e-02 0.003270 7.60e-01 0.97600
HCMV Infection 71 9.56e-01 9.78e-01 0.02010 -9.66e-03 -0.017600 8.88e-01 0.79800
HDMs demethylate histones 13 9.57e-01 9.78e-01 0.04860 2.95e-02 -0.038600 8.54e-01 0.81000
Downstream signal transduction 21 9.57e-01 9.78e-01 0.03780 -1.20e-02 0.035800 9.24e-01 0.77700
Fatty acyl-CoA biosynthesis 26 9.63e-01 9.82e-01 0.03080 7.05e-03 0.030000 9.50e-01 0.79200
Translation of Replicase and Assembly of the Replication Transcription Complex 10 9.67e-01 9.86e-01 0.04810 -4.50e-02 0.016900 8.05e-01 0.92600
Dual Incision in GG-NER 35 9.68e-01 9.86e-01 0.02450 -5.51e-03 -0.023900 9.55e-01 0.80700
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 10 9.74e-01 9.90e-01 0.04220 -8.72e-03 0.041300 9.62e-01 0.82100
Carboxyterminal post-translational modifications of tubulin 22 9.75e-01 9.90e-01 0.02700 2.29e-02 0.014200 8.52e-01 0.90900
RNA Polymerase I Promoter Clearance 41 9.77e-01 9.90e-01 0.01930 1.73e-02 0.008360 8.48e-01 0.92600
RNA Polymerase I Transcription 41 9.77e-01 9.90e-01 0.01930 1.73e-02 0.008360 8.48e-01 0.92600
Metabolism of steroid hormones 12 9.77e-01 9.90e-01 0.03540 -1.74e-02 -0.030800 9.17e-01 0.85400
Cellular response to heat stress 79 9.79e-01 9.90e-01 0.01380 5.09e-03 -0.012800 9.38e-01 0.84500
Prolonged ERK activation events 13 9.79e-01 9.90e-01 0.03360 1.38e-02 -0.030700 9.31e-01 0.84800
mRNA decay by 5’ to 3’ exoribonuclease 15 9.79e-01 9.90e-01 0.03040 3.27e-03 0.030200 9.83e-01 0.84000
Signaling by SCF-KIT 33 9.80e-01 9.90e-01 0.01990 -1.53e-02 -0.012700 8.79e-01 0.90000
Pyruvate metabolism and Citric Acid (TCA) cycle 41 9.82e-01 9.91e-01 0.01750 -1.33e-02 0.011300 8.83e-01 0.90000
Peroxisomal protein import 48 9.82e-01 9.91e-01 0.01560 -1.54e-02 -0.002190 8.53e-01 0.97900
DNA Double Strand Break Response 35 9.84e-01 9.92e-01 0.01770 -6.92e-03 0.016300 9.44e-01 0.86800
Tie2 Signaling 10 9.86e-01 9.93e-01 0.03160 -1.76e-02 0.026200 9.23e-01 0.88600
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 9.88e-01 9.93e-01 0.02090 -2.05e-02 -0.004100 8.81e-01 0.97600
COPII-mediated vesicle transport 51 9.89e-01 9.93e-01 0.01190 6.00e-03 0.010300 9.41e-01 0.89900
Prostacyclin signalling through prostacyclin receptor 11 9.89e-01 9.93e-01 0.02560 2.32e-02 0.010800 8.94e-01 0.95000
Potassium Channels 26 9.92e-01 9.95e-01 0.01480 5.86e-03 -0.013600 9.59e-01 0.90400
Adaptive Immune System 475 9.96e-01 9.98e-01 0.00249 1.95e-04 -0.002480 9.94e-01 0.92700
EPHB-mediated forward signaling 25 9.96e-01 9.98e-01 0.01020 -3.98e-03 0.009390 9.73e-01 0.93500
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 15 9.97e-01 9.98e-01 0.01110 -1.06e-02 -0.003140 9.43e-01 0.98300
Cell-cell junction organization 12 9.98e-01 9.98e-01 0.01150 2.99e-03 -0.011200 9.86e-01 0.94700


Detailed Gene set reports


Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
metric value
setSize 70
pMANOVA 3.26e-31
p.adjustMANOVA 3.8e-28
s.dist 0.812
s.RNA -0.807
s.meth -0.0892
p.RNA 1.46e-31
p.meth 0.198




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
EEF1A1 -4059 2014
EEF1B2 -4430 5616
EEF1D -4347 7650
EEF1G -4502 723
EEF2 -4461 1316
FAU -4443 5991
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
UBA52 -4076 4404



Peptide chain elongation

Peptide chain elongation
metric value
setSize 67
pMANOVA 1.74e-29
p.adjustMANOVA 1.01e-26
s.dist 0.805
s.RNA -0.799
s.meth -0.102
p.RNA 1.04e-29
p.meth 0.151




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
EEF1A1 -4059 2014
EEF2 -4461 1316
FAU -4443 5991
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
UBA52 -4076 4404



Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
metric value
setSize 76
pMANOVA 4.76e-29
p.adjustMANOVA 1.85e-26
s.dist 0.751
s.RNA -0.747
s.meth -0.0816
p.RNA 1.88e-29
p.meth 0.22




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
EIF3B -3751 -643
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
EIF3A -322 188
EIF3B -3751 -643
EIF3E 603 4012
EIF3F -4422 1788
EIF3G -4464 1822
EIF3H -2933 5015
EIF3I -4163 2663
EIF3J 3604 3059
EIF3K -3579 8409
EIF3L -4426 6698
EIF3M 1553 7241
FAU -4443 5991
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
UBA52 -4076 4404



Selenocysteine synthesis

Selenocysteine synthesis
metric value
setSize 68
pMANOVA 3.26e-27
p.adjustMANOVA 9.49e-25
s.dist 0.769
s.RNA -0.766
s.meth -0.065
p.RNA 7.64e-28
p.meth 0.355




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
EEFSEC -1190 6233
FAU -4443 5991
PSTK 1474 7792
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
SEPHS2 -2130 4134
UBA52 -4076 4404



Viral mRNA Translation

Viral mRNA Translation
metric value
setSize 67
pMANOVA 9.04e-27
p.adjustMANOVA 2.11e-24
s.dist 0.767
s.RNA -0.763
s.meth -0.0807
p.RNA 3.03e-27
p.meth 0.254




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
DNAJC3 1878 8319
FAU -4443 5991
GRSF1 662 1474
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
UBA52 -4076 4404



Eukaryotic Translation Termination

Eukaryotic Translation Termination
metric value
setSize 70
pMANOVA 1.73e-26
p.adjustMANOVA 3.37e-24
s.dist 0.747
s.RNA -0.742
s.meth -0.0808
p.RNA 6.07e-27
p.meth 0.244




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
APEH -3495 432
ETF1 1687 7120
FAU -4443 5991
GSPT1 3481 4369
N6AMT1 1750 326
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
TRMT112 -4331 7797
UBA52 -4076 4404



L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
metric value
setSize 85
pMANOVA 5.91e-26
p.adjustMANOVA 9.85e-24
s.dist 0.672
s.RNA -0.67
s.meth -0.0534
p.RNA 1.24e-26
p.meth 0.396




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
EIF3B -3751 -643
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 2834 6703
EIF2S2 2873 5131
EIF3A -322 188
EIF3B -3751 -643
EIF3E 603 4012
EIF3F -4422 1788
EIF3G -4464 1822
EIF3H -2933 5015
EIF3I -4163 2663
EIF3J 3604 3059
EIF3K -3579 8409
EIF3L -4426 6698
EIF3M 1553 7241
EIF4A1 -2281 5352
EIF4A2 3092 5327
EIF4B -3478 3082
EIF4E 3927 5614
EIF4G1 -3207 3220
EIF4H -4497 3675
FAU -4443 5991
PABPC1 1108 3737
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
UBA52 -4076 4404



Selenoamino acid metabolism

Selenoamino acid metabolism
metric value
setSize 76
pMANOVA 1.74e-25
p.adjustMANOVA 2.53e-23
s.dist 0.702
s.RNA -0.697
s.meth -0.0834
p.RNA 7.13e-26
p.meth 0.21




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
AHCY -4145 1896
AIMP2 -491 6011
CTH 3759 1184
EEF1E1 1868 3266
EEFSEC -1190 6233
FAU -4443 5991
GSR -3081 1990
PAPSS1 446 6222
PSTK 1474 7792
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
SCLY -529 681
SEPHS2 -2130 4134
TXNRD1 -917 214
UBA52 -4076 4404



GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
metric value
setSize 86
pMANOVA 1.36e-24
p.adjustMANOVA 1.76e-22
s.dist 0.651
s.RNA -0.649
s.meth -0.0431
p.RNA 2.3e-25
p.meth 0.49




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
EIF3B -3751 -643
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 2834 6703
EIF2S2 2873 5131
EIF3A -322 188
EIF3B -3751 -643
EIF3E 603 4012
EIF3F -4422 1788
EIF3G -4464 1822
EIF3H -2933 5015
EIF3I -4163 2663
EIF3J 3604 3059
EIF3K -3579 8409
EIF3L -4426 6698
EIF3M 1553 7241
EIF4A1 -2281 5352
EIF4A2 3092 5327
EIF4B -3478 3082
EIF4E 3927 5614
EIF4G1 -3207 3220
EIF4H -4497 3675
EIF5 2849 7143
EIF5B 3600 4202
FAU -4443 5991
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
UBA52 -4076 4404



Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
metric value
setSize 72
pMANOVA 1.45e-23
p.adjustMANOVA 1.49e-21
s.dist 0.694
s.RNA -0.69
s.meth -0.0731
p.RNA 4.32e-24
p.meth 0.285




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
EIF4G1 -3207 3220
ETF1 1687 7120
FAU -4443 5991
GSPT1 3481 4369
NCBP1 4364 6545
NCBP2 4238 3728
PABPC1 1108 3737
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
UBA52 -4076 4404
UPF1 -1679 712



Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
metric value
setSize 93
pMANOVA 1.54e-23
p.adjustMANOVA 1.49e-21
s.dist 0.612
s.RNA -0.611
s.meth -0.0402
p.RNA 2.55e-24
p.meth 0.504




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
EIF3B -3751 -643
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
EIF2B1 2350 5018
EIF2B2 -2151 6512
EIF2B3 1397 810
EIF2B4 -2706 5664
EIF2B5 -358 837
EIF2S1 2834 6703
EIF2S2 2873 5131
EIF3A -322 188
EIF3B -3751 -643
EIF3E 603 4012
EIF3F -4422 1788
EIF3G -4464 1822
EIF3H -2933 5015
EIF3I -4163 2663
EIF3J 3604 3059
EIF3K -3579 8409
EIF3L -4426 6698
EIF3M 1553 7241
EIF4A1 -2281 5352
EIF4A2 3092 5327
EIF4B -3478 3082
EIF4E 3927 5614
EIF4EBP1 -3124 3840
EIF4G1 -3207 3220
EIF4H -4497 3675
EIF5 2849 7143
EIF5B 3600 4202
FAU -4443 5991
PABPC1 1108 3737
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
UBA52 -4076 4404



Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
metric value
setSize 93
pMANOVA 1.54e-23
p.adjustMANOVA 1.49e-21
s.dist 0.612
s.RNA -0.611
s.meth -0.0402
p.RNA 2.55e-24
p.meth 0.504




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
EIF3B -3751 -643
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
EIF2B1 2350 5018
EIF2B2 -2151 6512
EIF2B3 1397 810
EIF2B4 -2706 5664
EIF2B5 -358 837
EIF2S1 2834 6703
EIF2S2 2873 5131
EIF3A -322 188
EIF3B -3751 -643
EIF3E 603 4012
EIF3F -4422 1788
EIF3G -4464 1822
EIF3H -2933 5015
EIF3I -4163 2663
EIF3J 3604 3059
EIF3K -3579 8409
EIF3L -4426 6698
EIF3M 1553 7241
EIF4A1 -2281 5352
EIF4A2 3092 5327
EIF4B -3478 3082
EIF4E 3927 5614
EIF4EBP1 -3124 3840
EIF4G1 -3207 3220
EIF4H -4497 3675
EIF5 2849 7143
EIF5B 3600 4202
FAU -4443 5991
PABPC1 1108 3737
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
UBA52 -4076 4404



Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
metric value
setSize 76
pMANOVA 5.39e-22
p.adjustMANOVA 4.84e-20
s.dist 0.652
s.RNA -0.649
s.meth -0.0628
p.RNA 1.32e-22
p.meth 0.345




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
ASNS 2780 2242
ATF3 3971 5006
ATF4 -2643 3847
CEBPB -1226 2587
CEBPG 2496 5011
DDIT3 2404 1641
EIF2AK4 -3217 6865
EIF2S1 2834 6703
EIF2S2 2873 5131
FAU -4443 5991
GCN1 -144 7280
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
TRIB3 1943 563
UBA52 -4076 4404



Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs
metric value
setSize 122
pMANOVA 1.22e-18
p.adjustMANOVA 1.01e-16
s.dist 0.474
s.RNA -0.471
s.meth -0.0496
p.RNA 3.02e-19
p.meth 0.346




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
PSMD9 -4165 -186
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
CASC3 -981 3341
CUL2 3754 6010
DAG1 -1582 2764
EIF4A3 -3458 5329
EIF4G1 -3207 3220
ETF1 1687 7120
FAU -4443 5991
GSPT1 3481 4369
LDB1 -3362 4806
NCBP1 4364 6545
NCBP2 4238 3728
PABPC1 1108 3737
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
RBX1 776 6226
RNPS1 -1587 2194
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
SLIT1 -1619 4573
UBA52 -4076 4404
UBB -3235 564
UBC -1858 2635
UPF2 4081 4021
UPF3A -542 6410
USP33 4371 -215
ZSWIM8 -2844 4681



SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
metric value
setSize 85
pMANOVA 2.35e-18
p.adjustMANOVA 1.83e-16
s.dist 0.56
s.RNA -0.553
s.meth -0.0906
p.RNA 1.36e-18
p.meth 0.15




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
FAU -4443 5991
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPN1 -3275 6578
RPN2 -618 3798
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
SEC11A -1249 6712
SEC11C 4169 5343
SEC61A1 -1168 5888
SEC61A2 3118 6659
SEC61B -3940 456
SEC61G 3366 2870
SPCS2 2940 7887
SPCS3 3778 4022
SRP14 428 5822
SRP19 4419 1191
SRP54 4625 3638
SRP68 -117 267
SRP72 2088 2265
SRPRB 1793 2077
SSR1 824 94
SSR2 -2402 1250
SSR3 2301 21
TRAM1 3103 636
UBA52 -4076 4404



Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
metric value
setSize 86
pMANOVA 8.86e-18
p.adjustMANOVA 6.08e-16
s.dist 0.549
s.RNA -0.547
s.meth -0.0534
p.RNA 1.96e-18
p.meth 0.393




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
SMG5 -3648 -216
SMG6 -1116 -684
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
CASC3 -981 3341
DCP1A 3875 4270
EIF4A3 -3458 5329
EIF4G1 -3207 3220
ETF1 1687 7120
FAU -4443 5991
GSPT1 3481 4369
NCBP1 4364 6545
NCBP2 4238 3728
PABPC1 1108 3737
PNRC2 4376 3788
PPP2CA -120 7715
PPP2R2A 4703 545
RNPS1 -1587 2194
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
SMG1 2879 8338
SMG5 -3648 -216
SMG6 -1116 -684
SMG7 2984 3120
SMG8 2596 8016
UBA52 -4076 4404
UPF1 -1679 712
UPF2 4081 4021
UPF3A -542 6410



Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
metric value
setSize 86
pMANOVA 8.86e-18
p.adjustMANOVA 6.08e-16
s.dist 0.549
s.RNA -0.547
s.meth -0.0534
p.RNA 1.96e-18
p.meth 0.393




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
SMG5 -3648 -216
SMG6 -1116 -684
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
CASC3 -981 3341
DCP1A 3875 4270
EIF4A3 -3458 5329
EIF4G1 -3207 3220
ETF1 1687 7120
FAU -4443 5991
GSPT1 3481 4369
NCBP1 4364 6545
NCBP2 4238 3728
PABPC1 1108 3737
PNRC2 4376 3788
PPP2CA -120 7715
PPP2R2A 4703 545
RNPS1 -1587 2194
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
SMG1 2879 8338
SMG5 -3648 -216
SMG6 -1116 -684
SMG7 2984 3120
SMG8 2596 8016
UBA52 -4076 4404
UPF1 -1679 712
UPF2 4081 4021
UPF3A -542 6410



Cellular response to starvation

Cellular response to starvation
metric value
setSize 119
pMANOVA 1.1e-17
p.adjustMANOVA 7.11e-16
s.dist 0.469
s.RNA -0.469
s.meth -0.000553
p.RNA 1.11e-18
p.meth 0.992




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
LAMTOR1 -4490 -649
RPS23 -4143 -355
LAMTOR2 -4374 -288
RPS8 -3241 -349
RPL36 -4456 -158

Click HERE to show all gene set members

All member genes
RNA meth
ASNS 2780 2242
ATF3 3971 5006
ATF4 -2643 3847
ATP6V0B -3862 4939
ATP6V0C -2681 2508
ATP6V0D1 -2963 5821
ATP6V0E1 -3186 5554
ATP6V0E2 45 -8
ATP6V1A 286 3932
ATP6V1B2 -937 2977
ATP6V1C1 786 3448
ATP6V1D 1060 449
ATP6V1E1 661 6230
ATP6V1F -4357 2967
ATP6V1G2 1311 7771
ATP6V1H -1097 5715
C12orf66 3427 7834
CEBPB -1226 2587
CEBPG 2496 5011
DDIT3 2404 1641
DEPDC5 2391 1033
EIF2AK4 -3217 6865
EIF2S1 2834 6703
EIF2S2 2873 5131
FAU -4443 5991
FLCN 1083 2472
FNIP1 3959 6015
GCN1 -144 7280
ITFG2 2203 3363
KPTN -2495 7869
LAMTOR1 -4490 -649
LAMTOR2 -4374 -288
LAMTOR3 3009 6767
LAMTOR4 -4140 1911
LAMTOR5 -3457 7083
MIOS 268 3553
MLST8 -2698 3421
MTOR -2466 1240
NPRL2 -1141 5068
NPRL3 100 7970
RHEB 2796 6691
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
RPTOR 308 -222
RRAGA -1598 8312
RRAGC 3286 7017
RRAGD -2441 3981
SEC13 -2693 7357
SEH1L 3110 6644
SESN1 -776 4595
SESN2 -263 1608
SLC38A9 1899 6434
SZT2 2031 935
TCIRG1 -2718 4563
TRIB3 1943 563
UBA52 -4076 4404
WDR24 -2267 2561
WDR59 -1010 7281



Axon guidance

Axon guidance
metric value
setSize 295
pMANOVA 1.68e-17
p.adjustMANOVA 1.03e-15
s.dist 0.298
s.RNA -0.297
s.meth -0.0227
p.RNA 2.94e-18
p.meth 0.506




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
DOK2 -3914 -569
MAPK3 -4544 -479
LIMK1 -2745 -632
RPS23 -4143 -355
RPS8 -3241 -349
CNTNAP1 -1712 -564
SEMA3A -1200 -798
SEMA4A -1006 -775
PSMD9 -4165 -186
RPL36 -4456 -158
MAP2K1 -3476 -148
GIT1 -3830 -130
RPS6KA4 -3821 -121
NCSTN -617 -457
SRC -1513 -92

Click HERE to show all gene set members

All member genes
RNA meth
ABL1 -2249 5977
ABL2 495 4991
ABLIM1 -601 4445
ABLIM2 -923 7101
ACTB -2121 4265
ACTG1 -3714 6428
ACTR2 2174 4951
ACTR3 1312 4499
ADAM10 419 3603
AGAP2 -2373 1611
AGRN 3879 3516
ALCAM -2962 465
ANK1 -564 253
ANK3 278 -855
AP2A1 -2951 1895
AP2M1 -4431 5734
AP2S1 -3760 3997
APH1A -4262 1663
APH1B 3033 2594
ARHGAP35 -3299 6432
ARHGAP39 772 8415
ARHGEF12 -1216 8154
ARHGEF7 -3086 964
ARPC1B -3966 2843
ARPC2 -83 5703
ARPC3 1376 4838
ARPC5 804 2343
CACNA1C -2576 3128
CACNA1I -3597 683
CACNB3 -1094 4217
CAP1 -1431 5579
CASC3 -981 3341
CD72 -3731 1306
CDC42 2291 7063
CDK5 -312 4651
CDK5R1 -3377 7721
CFL1 -4050 4075
CLASP1 -1376 3286
CLASP2 2090 2891
CLTA -2759 1476
CLTB -4330 600
CLTC -705 2682
CLTCL1 -2792 7791
CNTNAP1 -1712 -564
COL9A2 3094 1721
CREB1 2684 5066
CSNK2A2 1126 3957
CSNK2B -1331 7503
CUL2 3754 6010
CXCR4 -2975 6685
DAG1 -1582 2764
DLG1 3992 5149
DLG4 -2940 284
DNM1 3668 2162
DNM2 -3963 6605
DOK2 -3914 -569
DOK4 -3794 6128
DPYSL2 399 7422
EFNA3 -821 7466
EFNA4 -232 7073
EFNB2 -2730 8212
EIF4A3 -3458 5329
EIF4G1 -3207 3220
EPHA4 -3418 6667
EPHB6 -4154 1026
ERBB2 -1613 7893
ETF1 1687 7120
EVL -15 3804
EZR 1416 5759
FARP2 3207 1865
FAU -4443 5991
FES -4061 4123
FRS2 2876 165
FYN -1981 2811
GAB2 -2379 350
GIT1 -3830 -130
GRB10 -553 192
GRB2 -2429 5992
GRIN1 -2344 6304
GSK3B -648 3637
GSPT1 3481 4369
HRAS -2578 1490
HSP90AA1 2910 4876
HSP90AB1 585 829
IRS2 -4230 5305
ITGA1 1464 5574
ITGA2 4521 4016
ITGA5 -4058 6926
ITGAV 805 3287
ITSN1 3075 5424
KRAS 4256 4020
LDB1 -3362 4806
LIMK1 -2745 -632
LIMK2 -460 4617
LYPLA2 -4212 2325
MAP2K1 -3476 -148
MAP2K2 -4508 8056
MAPK1 -664 2770
MAPK14 -471 2235
MAPK3 -4544 -479
MAPK7 -1945 3019
MAPK8 -584 6176
MYH10 2967 3825
MYH9 -3031 3393
MYL12A -828 3613
MYL6 -4411 4209
MYO9B -1527 3151
NCBP1 4364 6545
NCBP2 4238 3728
NCK1 1391 1103
NCK2 -4019 2464
NCSTN -617 -457
NEO1 -2813 949
NTN1 -3237 8233
NUMB 558 1647
PABPC1 1108 3737
PAK1 2857 4972
PAK2 1920 2509
PAK4 -2553 779
PDLIM7 -1357 142
PFN1 -3627 2497
PFN2 -1285 8232
PIK3CA 2842 3290
PIK3CD -2911 153
PIK3R1 -2375 5157
PIK3R2 -1983 5365
PIK3R3 3664 3533
PIP5K1C -3773 8050
PITPNA 727 1699
PLCG1 345 5809
PLXNA2 -3298 4087
PLXNC1 545 1218
PLXND1 -3058 6377
PPP3CB 2850 5276
PRKACA -2849 3985
PRKACB 1232 7740
PRKAR2A -142 532
PRKCA -2013 8000
PRKCQ -36 3938
PRNP -880 861
PSEN1 1406 1724
PSEN2 -29 4736
PSENEN -1546 5332
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PTK2 -271 2498
PTPN11 404 3777
PTPRA -3076 5280
PTPRC 3435 1766
RAC1 1432 7511
RANBP9 541 4150
RASA1 4274 3050
RBX1 776 6226
RHOA -152 1886
RHOB 1489 4751
RND1 3209 344
RNPS1 -1587 2194
ROCK1 3813 2216
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS6KA1 -2403 6292
RPS6KA2 -1652 6457
RPS6KA4 -3821 -121
RPS6KA5 4565 7378
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
RRAS 2000 4131
SDCBP 183 7446
SEMA3A -1200 -798
SEMA4A -1006 -775
SEMA4D -659 721
SEMA7A 32 4968
SHC1 1742 7320
SIAH1 1400 5770
SIAH2 2663 1878
SLIT1 -1619 4573
SOS1 4314 3280
SOS2 1177 87
SPTAN1 -2478 372
SPTBN1 -2562 7757
SPTBN5 802 2482
SRC -1513 -92
SRGAP1 3705 7388
SRGAP3 4164 2145
ST8SIA4 3378 3040
TLN1 -3378 2103
TRIO -2671 8416
TRPC1 2903 4764
TYROBP -3335 835
UBA52 -4076 4404
UBB -3235 564
UBC -1858 2635
UPF2 4081 4021
UPF3A -542 6410
USP33 4371 -215
VASP -2524 3426
VAV2 780 7727
VAV3 -3913 8297
WASL 3043 7402
YES1 1814 -624
ZSWIM8 -2844 4681



Nervous system development

Nervous system development
metric value
setSize 307
pMANOVA 1.45e-16
p.adjustMANOVA 8.43e-15
s.dist 0.284
s.RNA -0.283
s.meth -0.0229
p.RNA 2.61e-17
p.meth 0.493




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
DOK2 -3914 -569
MAPK3 -4544 -479
LIMK1 -2745 -632
RPS23 -4143 -355
RPS8 -3241 -349
CNTNAP1 -1712 -564
SEMA3A -1200 -798
SEMA4A -1006 -775
PSMD9 -4165 -186
RPL36 -4456 -158
MAP2K1 -3476 -148
GIT1 -3830 -130
RPS6KA4 -3821 -121
NCSTN -617 -457
SRC -1513 -92

Click HERE to show all gene set members

All member genes
RNA meth
ABL1 -2249 5977
ABL2 495 4991
ABLIM1 -601 4445
ABLIM2 -923 7101
ACTB -2121 4265
ACTG1 -3714 6428
ACTR2 2174 4951
ACTR3 1312 4499
ADAM10 419 3603
AGAP2 -2373 1611
AGRN 3879 3516
ALCAM -2962 465
ANK1 -564 253
ANK3 278 -855
AP2A1 -2951 1895
AP2M1 -4431 5734
AP2S1 -3760 3997
APH1A -4262 1663
APH1B 3033 2594
ARHGAP35 -3299 6432
ARHGAP39 772 8415
ARHGEF12 -1216 8154
ARHGEF7 -3086 964
ARPC1B -3966 2843
ARPC2 -83 5703
ARPC3 1376 4838
ARPC5 804 2343
CACNA1C -2576 3128
CACNA1I -3597 683
CACNB3 -1094 4217
CAP1 -1431 5579
CASC3 -981 3341
CD72 -3731 1306
CDC42 2291 7063
CDK5 -312 4651
CDK5R1 -3377 7721
CFL1 -4050 4075
CLASP1 -1376 3286
CLASP2 2090 2891
CLTA -2759 1476
CLTB -4330 600
CLTC -705 2682
CLTCL1 -2792 7791
CNTNAP1 -1712 -564
COL9A2 3094 1721
CREB1 2684 5066
CSNK2A2 1126 3957
CSNK2B -1331 7503
CUL2 3754 6010
CXCR4 -2975 6685
CYP51A1 3547 2962
DAG1 -1582 2764
DLG1 3992 5149
DLG4 -2940 284
DNM1 3668 2162
DNM2 -3963 6605
DOK2 -3914 -569
DOK4 -3794 6128
DPYSL2 399 7422
EFNA3 -821 7466
EFNA4 -232 7073
EFNB2 -2730 8212
EGR2 923 5319
EIF4A3 -3458 5329
EIF4G1 -3207 3220
EPHA4 -3418 6667
EPHB6 -4154 1026
ERBB2 -1613 7893
ETF1 1687 7120
EVL -15 3804
EZR 1416 5759
FARP2 3207 1865
FAU -4443 5991
FES -4061 4123
FRS2 2876 165
FYN -1981 2811
GAB2 -2379 350
GIT1 -3830 -130
GRB10 -553 192
GRB2 -2429 5992
GRIN1 -2344 6304
GSK3B -648 3637
GSPT1 3481 4369
HDAC2 357 4593
HMGCR 615 4936
HRAS -2578 1490
HSP90AA1 2910 4876
HSP90AB1 585 829
IRS2 -4230 5305
ITGA1 1464 5574
ITGA2 4521 4016
ITGA5 -4058 6926
ITGAV 805 3287
ITSN1 3075 5424
KRAS 4256 4020
LAMA2 -594 5768
LDB1 -3362 4806
LIMK1 -2745 -632
LIMK2 -460 4617
LYPLA2 -4212 2325
MAP2K1 -3476 -148
MAP2K2 -4508 8056
MAPK1 -664 2770
MAPK14 -471 2235
MAPK3 -4544 -479
MAPK7 -1945 3019
MAPK8 -584 6176
MBP -1991 4049
MPZ -1876 5102
MYH10 2967 3825
MYH9 -3031 3393
MYL12A -828 3613
MYL6 -4411 4209
MYO9B -1527 3151
NAB1 4175 1502
NAB2 890 3007
NCBP1 4364 6545
NCBP2 4238 3728
NCK1 1391 1103
NCK2 -4019 2464
NCSTN -617 -457
NEO1 -2813 949
NTN1 -3237 8233
NUMB 558 1647
PABPC1 1108 3737
PAK1 2857 4972
PAK2 1920 2509
PAK4 -2553 779
PDLIM7 -1357 142
PFN1 -3627 2497
PFN2 -1285 8232
PIK3CA 2842 3290
PIK3CD -2911 153
PIK3R1 -2375 5157
PIK3R2 -1983 5365
PIK3R3 3664 3533
PIP5K1C -3773 8050
PITPNA 727 1699
PLCG1 345 5809
PLXNA2 -3298 4087
PLXNC1 545 1218
PLXND1 -3058 6377
PPP3CB 2850 5276
PRKACA -2849 3985
PRKACB 1232 7740
PRKAR2A -142 532
PRKCA -2013 8000
PRKCQ -36 3938
PRNP -880 861
PSEN1 1406 1724
PSEN2 -29 4736
PSENEN -1546 5332
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PTK2 -271 2498
PTPN11 404 3777
PTPRA -3076 5280
PTPRC 3435 1766
RAC1 1432 7511
RANBP9 541 4150
RASA1 4274 3050
RBX1 776 6226
RHOA -152 1886
RHOB 1489 4751
RND1 3209 344
RNPS1 -1587 2194
ROCK1 3813 2216
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS6KA1 -2403 6292
RPS6KA2 -1652 6457
RPS6KA4 -3821 -121
RPS6KA5 4565 7378
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
RRAS 2000 4131
SDCBP 183 7446
SEMA3A -1200 -798
SEMA4A -1006 -775
SEMA4D -659 721
SEMA7A 32 4968
SHC1 1742 7320
SIAH1 1400 5770
SIAH2 2663 1878
SLIT1 -1619 4573
SMARCA4 -3042 2893
SOS1 4314 3280
SOS2 1177 87
SPTAN1 -2478 372
SPTBN1 -2562 7757
SPTBN5 802 2482
SRC -1513 -92
SREBF2 325 3407
SRGAP1 3705 7388
SRGAP3 4164 2145
ST8SIA4 3378 3040
TLN1 -3378 2103
TRIO -2671 8416
TRPC1 2903 4764
TYROBP -3335 835
UBA52 -4076 4404
UBB -3235 564
UBC -1858 2635
UPF2 4081 4021
UPF3A -542 6410
USP33 4371 -215
UTRN 1865 460
VASP -2524 3426
VAV2 780 7727
VAV3 -3913 8297
WASL 3043 7402
YES1 1814 -624
ZSWIM8 -2844 4681



Signaling by ROBO receptors

Signaling by ROBO receptors
metric value
setSize 153
pMANOVA 1.71e-15
p.adjustMANOVA 9.52e-14
s.dist 0.386
s.RNA -0.386
s.meth -0.0165
p.RNA 2.26e-16
p.meth 0.727




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
PSMD9 -4165 -186
RPL36 -4456 -158
SRC -1513 -92

Click HERE to show all gene set members

All member genes
RNA meth
ABL1 -2249 5977
ABL2 495 4991
ARHGAP39 772 8415
CAP1 -1431 5579
CASC3 -981 3341
CDC42 2291 7063
CLASP1 -1376 3286
CLASP2 2090 2891
CUL2 3754 6010
CXCR4 -2975 6685
DAG1 -1582 2764
EIF4A3 -3458 5329
EIF4G1 -3207 3220
ETF1 1687 7120
EVL -15 3804
FAU -4443 5991
GSPT1 3481 4369
LDB1 -3362 4806
MYO9B -1527 3151
NCBP1 4364 6545
NCBP2 4238 3728
NCK1 1391 1103
NCK2 -4019 2464
NTN1 -3237 8233
PABPC1 1108 3737
PAK1 2857 4972
PAK2 1920 2509
PAK4 -2553 779
PFN1 -3627 2497
PFN2 -1285 8232
PPP3CB 2850 5276
PRKACA -2849 3985
PRKACB 1232 7740
PRKAR2A -142 532
PRKCA -2013 8000
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
RAC1 1432 7511
RBX1 776 6226
RHOA -152 1886
RNPS1 -1587 2194
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
SLIT1 -1619 4573
SOS1 4314 3280
SOS2 1177 87
SRC -1513 -92
SRGAP1 3705 7388
SRGAP3 4164 2145
UBA52 -4076 4404
UBB -3235 564
UBC -1858 2635
UPF2 4081 4021
UPF3A -542 6410
USP33 4371 -215
VASP -2524 3426
ZSWIM8 -2844 4681



Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication
metric value
setSize 110
pMANOVA 5.57e-15
p.adjustMANOVA 2.95e-13
s.dist 0.446
s.RNA -0.445
s.meth -0.0307
p.RNA 8.96e-16
p.meth 0.58




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158
POLR2A -851 -175

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
DNAJC3 1878 8319
FAU -4443 5991
GRSF1 662 1474
GTF2F1 -3630 1349
GTF2F2 199 4275
HSP90AA1 2910 4876
IPO5 -719 8363
NDC1 1276 -274
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
PARP1 -684 377
POLR2A -851 -175
POLR2B 647 1497
POLR2C -2229 4506
POLR2D 2056 1352
POLR2E -4392 2995
POLR2F -4196 6542
POLR2G -4186 8051
POLR2H -3384 7582
POLR2I -4069 6360
POLR2K 3044 2463
POM121 -1366 5167
POM121C -3196 5663
RAE1 1852 710
RANBP2 3105 4436
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
SEC13 -2693 7357
SEH1L 3110 6644
TPR 3482 5135
UBA52 -4076 4404



Translation

Translation
metric value
setSize 234
pMANOVA 3.99e-14
p.adjustMANOVA 2.02e-12
s.dist 0.295
s.RNA -0.282
s.meth -0.087
p.RNA 1.59e-13
p.meth 0.0228




Top 20 genes
Gene RNA meth
MRPL23 -4336 -853
RPS2 -4547 -712
EIF3B -3751 -643
MRPL27 -3016 -718
RPS23 -4143 -355
MRPS2 -3260 -421
MRPL45 -1907 -666
GADD45GIP1 -3375 -350
MRPL37 -3816 -302
RPS8 -3241 -349
FARS2 -1656 -607
MRPL20 -1238 -789
RPL36 -4456 -158
MRPL9 -1319 -494
MRPL51 -2226 -289
MRPL2 -796 -436
MRPL52 -1730 -146

Click HERE to show all gene set members

All member genes
RNA meth
AARS2 394 2842
AIMP2 -491 6011
APEH -3495 432
AURKAIP1 -4060 3883
CARS2 -1489 171
CHCHD1 -3480 3680
DAP3 -720 143
DARS2 1534 8397
EARS2 1086 783
EEF1A1 -4059 2014
EEF1B2 -4430 5616
EEF1D -4347 7650
EEF1E1 1868 3266
EEF1G -4502 723
EEF2 -4461 1316
EIF2B1 2350 5018
EIF2B2 -2151 6512
EIF2B3 1397 810
EIF2B4 -2706 5664
EIF2B5 -358 837
EIF2S1 2834 6703
EIF2S2 2873 5131
EIF3A -322 188
EIF3B -3751 -643
EIF3E 603 4012
EIF3F -4422 1788
EIF3G -4464 1822
EIF3H -2933 5015
EIF3I -4163 2663
EIF3J 3604 3059
EIF3K -3579 8409
EIF3L -4426 6698
EIF3M 1553 7241
EIF4A1 -2281 5352
EIF4A2 3092 5327
EIF4B -3478 3082
EIF4E 3927 5614
EIF4EBP1 -3124 3840
EIF4G1 -3207 3220
EIF4H -4497 3675
EIF5 2849 7143
EIF5B 3600 4202
ERAL1 494 3775
ETF1 1687 7120
FARS2 -1656 -607
FARSA -4009 5701
FARSB 3544 5328
FAU -4443 5991
GADD45GIP1 -3375 -350
GFM1 -738 1365
GFM2 3584 4081
GSPT1 3481 4369
HARS2 3385 1362
IARS2 -352 2685
LARS2 -2386 1517
MARS2 1125 2590
MRPL1 4173 218
MRPL10 -67 2279
MRPL11 -3470 4034
MRPL12 -4080 8276
MRPL13 3561 7625
MRPL14 -3302 6345
MRPL15 -445 5045
MRPL16 990 7696
MRPL18 87 3878
MRPL19 3449 6054
MRPL2 -796 -436
MRPL20 -1238 -789
MRPL21 -1842 1605
MRPL22 1422 6263
MRPL23 -4336 -853
MRPL24 -4348 448
MRPL27 -3016 -718
MRPL30 -38 5691
MRPL32 2701 914
MRPL33 -698 2858
MRPL34 -4302 789
MRPL35 1913 463
MRPL36 -1445 8337
MRPL37 -3816 -302
MRPL38 -2631 6626
MRPL39 4267 4899
MRPL4 98 7667
MRPL41 -2003 1540
MRPL42 4747 3628
MRPL43 -4473 3498
MRPL44 2952 2675
MRPL45 -1907 -666
MRPL46 1030 5122
MRPL47 3219 6845
MRPL48 -1552 5652
MRPL49 -2036 6807
MRPL50 2695 3835
MRPL51 -2226 -289
MRPL52 -1730 -146
MRPL53 -4031 971
MRPL54 -4543 1889
MRPL55 -3044 7479
MRPL57 -2321 4246
MRPL9 -1319 -494
MRPS10 3930 -389
MRPS11 -407 1648
MRPS12 -3911 1712
MRPS14 4163 1977
MRPS15 -3096 3677
MRPS16 -2290 2543
MRPS17 1706 3827
MRPS18A 459 7695
MRPS18B 1092 -766
MRPS18C 1802 6987
MRPS2 -3260 -421
MRPS21 -3598 1464
MRPS22 2504 6094
MRPS23 -909 2254
MRPS24 -4021 3376
MRPS25 172 6261
MRPS26 -4108 8045
MRPS27 2430 1421
MRPS28 365 3713
MRPS30 857 5477
MRPS31 3824 6499
MRPS33 -531 3752
MRPS34 -4535 6347
MRPS35 4214 3581
MRPS36 -1003 2215
MRPS5 423 1128
MRPS6 -3025 3325
MRPS7 -4319 1415
MRPS9 -806 7560
MTFMT 989 3569
MTIF2 2892 5667
MTIF3 4351 2054
MTRF1L 3157 2552
N6AMT1 1750 326
NARS2 2082 4530
OXA1L -2215 3023
PABPC1 1108 3737
PARS2 2177 742
PPA1 1586 5
PPA2 2838 5436
PTCD3 3860 1343
RARS2 3978 315
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPN1 -3275 6578
RPN2 -618 3798
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
SARS2 -4150 2722
SEC11A -1249 6712
SEC11C 4169 5343
SEC61A1 -1168 5888
SEC61A2 3118 6659
SEC61B -3940 456
SEC61G 3366 2870
SPCS2 2940 7887
SPCS3 3778 4022
SRP14 428 5822
SRP19 4419 1191
SRP54 4625 3638
SRP68 -117 267
SRP72 2088 2265
SRPRB 1793 2077
SSR1 824 94
SSR2 -2402 1250
SSR3 2301 21
TARS2 4402 2423
TRAM1 3103 636
TRMT112 -4331 7797
TSFM -711 5010
TUFM -3801 1422
UBA52 -4076 4404
VARS2 1581 2873
WARS2 2567 -77
YARS2 2356 4118



Cellular responses to external stimuli

Cellular responses to external stimuli
metric value
setSize 457
pMANOVA 1.78e-12
p.adjustMANOVA 8.63e-11
s.dist 0.202
s.RNA -0.202
s.meth -0.0134
p.RNA 2.83e-13
p.meth 0.627




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
LAMTOR1 -4490 -649
AGO1 -3251 -803
MAPK3 -4544 -479
DCTN2 -4492 -467
RPS23 -4143 -355
LAMTOR2 -4374 -288
HIF1AN -3580 -320
RPS8 -3241 -349
COX5B -3992 -244
PSMD9 -4165 -186
RPL36 -4456 -158
TXNRD2 -3686 -152
EHMT1 -935 -506
NCF4 -3240 -141
STIP1 -2074 -119
SIN3B -604 -271
CAT -305 -221
AJUBA -71 -835

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
ABCC1 1685 1830
ACD -3409 3685
ACTR10 1835 5133
ACTR1A -3386 886
AGO1 -3251 -803
AGO3 4723 8331
AJUBA -71 -835
AKT1S1 -4339 5797
ANAPC1 -351 3351
ANAPC10 2240 -306
ANAPC11 -4328 7059
ANAPC15 -4465 2693
ANAPC16 -376 6873
ANAPC2 -2785 1387
ANAPC4 4302 1495
ANAPC5 1020 3142
ANAPC7 4469 869
ARNT 928 5016
ARNTL 621 5761
ASNS 2780 2242
ATF3 3971 5006
ATF4 -2643 3847
ATF5 1458 279
ATM 1634 2443
ATOX1 -2888 8027
ATP6V0B -3862 4939
ATP6V0C -2681 2508
ATP6V0D1 -2963 5821
ATP6V0E1 -3186 5554
ATP6V0E2 45 -8
ATP6V1A 286 3932
ATP6V1B2 -937 2977
ATP6V1C1 786 3448
ATP6V1D 1060 449
ATP6V1E1 661 6230
ATP6V1F -4357 2967
ATP6V1G2 1311 7771
ATP6V1H -1097 5715
ATR 3578 3477
BACH1 664 -225
BAG1 -893 3503
BAG2 3792 2917
BAG3 -2879 1533
BAG4 1979 2195
BAG5 1614 5951
BLVRA 3894 8206
BLVRB -4155 2113
BMI1 2392 4629
C12orf66 3427 7834
CABIN1 -2861 3096
CAMK2D -1254 3808
CAMK2G -669 31
CAPZA1 2568 7829
CAPZA2 2014 3750
CAPZB -2598 3064
CAT -305 -221
CBX4 -2606 5617
CBX6 -3140 7540
CBX8 -1341 73
CCAR2 -306 1073
CCNA2 2525 6920
CCNE1 4347 6755
CCNE2 144 5076
CCS -3520 5087
CDC16 2944 7052
CDC23 3474 4397
CDK2 360 6577
CDK4 -3226 6700
CDK6 3156 2094
CDKN1A 205 7579
CDKN1B -296 1658
CDKN2A 746 4878
CDKN2C -3749 4213
CDKN2D -4528 5171
CEBPB -1226 2587
CEBPG 2496 5011
CHD9 1137 6134
CITED2 -2906 6665
CLOCK 3411 6485
COX11 2934 3025
COX14 -3473 3855
COX16 3674 3560
COX19 3545 298
COX20 3562 3497
COX4I1 -3349 4535
COX5A -3813 3397
COX5B -3992 -244
COX6A1 -4298 1809
COX6B1 -2925 2356
COX6C -2174 2408
COX7A2L -489 5803
COX7C -3932 603
COX8A -4207 3949
CREB1 2684 5066
CREBBP -2131 6830
CRTC1 -2099 6020
CRTC2 -1457 902
CRTC3 -3424 8114
CSNK2A2 1126 3957
CSNK2B -1331 7503
CSRP1 -2894 3408
CUL1 4686 1579
CUL2 3754 6010
CUL3 834 3767
CYBA -3513 5379
CYCS 2102 2450
DCTN2 -4492 -467
DCTN3 -3524 4086
DCTN4 2512 3763
DCTN5 -513 7654
DCTN6 3252 6435
DDIT3 2404 1641
DEDD2 -3158 2856
DEPDC5 2391 1033
DNAJA1 3650 5172
DNAJA2 580 7945
DNAJA4 53 2213
DNAJB1 -3927 5251
DNAJB6 -2867 7519
DNAJC2 3810 421
DYNC1H1 -621 1172
DYNC1I2 -163 261
DYNC1LI1 2931 6081
DYNC1LI2 961 3137
DYNLL1 -1533 5391
DYNLL2 -2741 3308
E2F1 2805 1130
E2F2 61 3021
E2F3 2817 5634
EED 3870 2932
EEF1A1 -4059 2014
EGLN1 797 5177
EGLN2 -4035 4388
EHMT1 -935 -506
EHMT2 -3090 5106
EIF2AK1 530 1917
EIF2AK4 -3217 6865
EIF2S1 2834 6703
EIF2S2 2873 5131
EP300 1012 3364
EP400 723 2028
EPAS1 2652 -699
ERF -3959 5827
ERO1A 3643 -809
ETS1 -2368 4334
ETS2 -3941 1436
EZH2 4487 4485
FAU -4443 5991
FBXL17 -3428 4856
FKBP4 -1987 4677
FKBP5 389 1867
FLCN 1083 2472
FNIP1 3959 6015
FOS -3745 4083
FZR1 -1998 7430
GCN1 -144 7280
GPX1 -4408 2183
GRB10 -553 192
GSK3B -648 3637
GSR -3081 1990
GSTP1 -3395 6832
HDAC3 -2463 8308
HIF1A -446 4115
HIF1AN -3580 -320
HIGD1A 1475 4139
HIRA -1788 6286
HM13 -3720 1856
HMGA1 -3906 5560
HMOX2 -3873 704
HSBP1 715 1432
HSF1 -2825 5763
HSP90AA1 2910 4876
HSP90AB1 585 829
HSPA13 1858 4247
HSPA14 4622 7441
HSPA1A -3404 1113
HSPA1B 1982 755
HSPA1L -349 336
HSPA2 -2262 5784
HSPA4 1179 8237
HSPA4L 3248 7845
HSPA9 -588 5882
HSPH1 3950 3890
ID1 -4373 5853
ITFG2 2203 3363
JUN -2852 2775
KAT5 -1917 5607
KDM6B -1439 2846
KEAP1 -2853 5049
KPTN -2495 7869
LAMTOR1 -4490 -649
LAMTOR2 -4374 -288
LAMTOR3 3009 6767
LAMTOR4 -4140 1911
LAMTOR5 -3457 7083
LIMD1 970 2244
LMNB1 3532 4104
LRPPRC 1645 376
MAFK -2135 1829
MAP2K3 -3178 38
MAP2K4 569 3168
MAP2K6 2656 2172
MAP2K7 -3762 2099
MAP3K5 947 4831
MAP4K4 -1325 7027
MAPK1 -664 2770
MAPK14 -471 2235
MAPK3 -4544 -479
MAPK7 -1945 3019
MAPK8 -584 6176
MAPK9 -2019 1159
MAPKAPK2 -3852 1423
MAPKAPK3 -2308 58
MDM2 4685 1092
MDM4 3961 1115
MED1 884 5989
MEF2D -2928 4570
MINK1 -3981 2629
MIOS 268 3553
MLST8 -2698 3421
MOV10 4456 7640
MRPL18 87 3878
MT1F -2966 2906
MT1X 721 3532
MT2A 1283 3780
MTF1 1105 2958
MTOR -2466 1240
NBN 3430 1983
NCF4 -3240 -141
NCOA2 2520 7322
NCOA6 1077 761
NCOR1 1467 1101
NCOR2 -3180 580
NDC1 1276 -274
NDUFA4 -2791 2018
NFE2L2 3859 5438
NLRP3 -1832 6403
NPRL2 -1141 5068
NPRL3 100 7970
NR1D1 -3155 5009
NR3C1 795 4250
NR3C2 -508 6632
NUDT2 -2712 6673
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
P4HB -3964 6831
PHC1 -3551 606
PHC2 -3417 4319
PHC3 3656 522
POM121 -1366 5167
POM121C -3196 5663
PPP1R15A -4074 5649
PRDX1 1389 4095
PRDX2 -2836 6462
PRDX3 1144 3939
PRDX5 -4506 7719
PRDX6 -3456 4160
PRKCD -1518 8196
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PTGES3 3489 2735
RAD50 4672 179
RAE1 1852 710
RAI1 -3348 7815
RANBP2 3105 4436
RB1 1147 1518
RBBP4 1636 2574
RBX1 776 6226
RELA -3471 5749
RHEB 2796 6691
RING1 -3885 4529
RNF2 2490 7500
RORA 524 7068
RPA1 -1575 8080
RPA3 956 1331
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS19BP1 -4498 1425
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS6KA1 -2403 6292
RPS6KA2 -1652 6457
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
RPTOR 308 -222
RRAGA -1598 8312
RRAGC 3286 7017
RRAGD -2441 3981
SCMH1 -3339 7093
SCO1 1765 2221
SCO2 2396 237
SEC13 -2693 7357
SEH1L 3110 6644
SERPINH1 -3383 1350
SESN1 -776 4595
SESN2 -263 1608
SIN3A -798 1529
SIN3B -604 -271
SIRT1 2340 6815
SKP1 2353 3193
SKP2 4608 3439
SLC38A9 1899 6434
SOD1 -1988 6467
SOD2 1499 6344
SP1 -1581 2146
ST13 -2058 6559
STAT3 1093 7085
STIP1 -2074 -119
SURF1 -1424 4051
SZT2 2031 935
TACO1 -4362 1969
TBL1XR1 1832 1367
TCIRG1 -2718 4563
TERF1 2606 5033
TERF2 2089 5105
TERF2IP -1882 7036
TFDP1 1708 471
TFDP2 -2800 3770
TINF2 -2823 4849
TNIK -398 4975
TNRC6A 4363 6086
TNRC6B 2494 787
TP53 -92 1992
TPR 3482 5135
TRIB3 1943 563
TXN -441 339
TXN2 -4048 5130
TXNIP 508 3975
TXNRD1 -917 214
TXNRD2 -3686 -152
UBA52 -4076 4404
UBB -3235 564
UBC -1858 2635
UBE2C -2854 1584
UBE2D1 273 4705
UBE2D2 -1452 4272
UBE2D3 1741 2455
UBE2E1 -754 3149
UBE2S 707 -550
UBN1 356 7888
VCP -3583 7877
VEGFA -3785 832
VHL -1931 2728
WDR24 -2267 2561
WDR59 -1010 7281
XPO1 4524 5628
YWHAE 431 6202



Cellular responses to stress

Cellular responses to stress
metric value
setSize 452
pMANOVA 2.15e-12
p.adjustMANOVA 1e-10
s.dist 0.203
s.RNA -0.202
s.meth -0.0124
p.RNA 3.31e-13
p.meth 0.656




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
LAMTOR1 -4490 -649
AGO1 -3251 -803
MAPK3 -4544 -479
DCTN2 -4492 -467
RPS23 -4143 -355
LAMTOR2 -4374 -288
HIF1AN -3580 -320
RPS8 -3241 -349
COX5B -3992 -244
PSMD9 -4165 -186
RPL36 -4456 -158
TXNRD2 -3686 -152
EHMT1 -935 -506
NCF4 -3240 -141
STIP1 -2074 -119
SIN3B -604 -271
CAT -305 -221
AJUBA -71 -835

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
ABCC1 1685 1830
ACD -3409 3685
ACTR10 1835 5133
ACTR1A -3386 886
AGO1 -3251 -803
AGO3 4723 8331
AJUBA -71 -835
AKT1S1 -4339 5797
ANAPC1 -351 3351
ANAPC10 2240 -306
ANAPC11 -4328 7059
ANAPC15 -4465 2693
ANAPC16 -376 6873
ANAPC2 -2785 1387
ANAPC4 4302 1495
ANAPC5 1020 3142
ANAPC7 4469 869
ARNT 928 5016
ARNTL 621 5761
ASNS 2780 2242
ATF3 3971 5006
ATF4 -2643 3847
ATF5 1458 279
ATM 1634 2443
ATOX1 -2888 8027
ATP6V0B -3862 4939
ATP6V0C -2681 2508
ATP6V0D1 -2963 5821
ATP6V0E1 -3186 5554
ATP6V0E2 45 -8
ATP6V1A 286 3932
ATP6V1B2 -937 2977
ATP6V1C1 786 3448
ATP6V1D 1060 449
ATP6V1E1 661 6230
ATP6V1F -4357 2967
ATP6V1G2 1311 7771
ATP6V1H -1097 5715
ATR 3578 3477
BACH1 664 -225
BAG1 -893 3503
BAG2 3792 2917
BAG3 -2879 1533
BAG4 1979 2195
BAG5 1614 5951
BLVRA 3894 8206
BLVRB -4155 2113
BMI1 2392 4629
C12orf66 3427 7834
CABIN1 -2861 3096
CAMK2D -1254 3808
CAMK2G -669 31
CAPZA1 2568 7829
CAPZA2 2014 3750
CAPZB -2598 3064
CAT -305 -221
CBX4 -2606 5617
CBX6 -3140 7540
CBX8 -1341 73
CCAR2 -306 1073
CCNA2 2525 6920
CCNE1 4347 6755
CCNE2 144 5076
CCS -3520 5087
CDC16 2944 7052
CDC23 3474 4397
CDK2 360 6577
CDK4 -3226 6700
CDK6 3156 2094
CDKN1A 205 7579
CDKN1B -296 1658
CDKN2A 746 4878
CDKN2C -3749 4213
CDKN2D -4528 5171
CEBPB -1226 2587
CEBPG 2496 5011
CHD9 1137 6134
CITED2 -2906 6665
CLOCK 3411 6485
COX11 2934 3025
COX14 -3473 3855
COX16 3674 3560
COX19 3545 298
COX20 3562 3497
COX4I1 -3349 4535
COX5A -3813 3397
COX5B -3992 -244
COX6A1 -4298 1809
COX6B1 -2925 2356
COX6C -2174 2408
COX7A2L -489 5803
COX7C -3932 603
COX8A -4207 3949
CREB1 2684 5066
CREBBP -2131 6830
CRTC1 -2099 6020
CRTC2 -1457 902
CRTC3 -3424 8114
CSNK2A2 1126 3957
CSNK2B -1331 7503
CUL1 4686 1579
CUL2 3754 6010
CUL3 834 3767
CYBA -3513 5379
CYCS 2102 2450
DCTN2 -4492 -467
DCTN3 -3524 4086
DCTN4 2512 3763
DCTN5 -513 7654
DCTN6 3252 6435
DDIT3 2404 1641
DEDD2 -3158 2856
DEPDC5 2391 1033
DNAJA1 3650 5172
DNAJA2 580 7945
DNAJA4 53 2213
DNAJB1 -3927 5251
DNAJB6 -2867 7519
DNAJC2 3810 421
DYNC1H1 -621 1172
DYNC1I2 -163 261
DYNC1LI1 2931 6081
DYNC1LI2 961 3137
DYNLL1 -1533 5391
DYNLL2 -2741 3308
E2F1 2805 1130
E2F2 61 3021
E2F3 2817 5634
EED 3870 2932
EEF1A1 -4059 2014
EGLN1 797 5177
EGLN2 -4035 4388
EHMT1 -935 -506
EHMT2 -3090 5106
EIF2AK1 530 1917
EIF2AK4 -3217 6865
EIF2S1 2834 6703
EIF2S2 2873 5131
EP300 1012 3364
EP400 723 2028
EPAS1 2652 -699
ERF -3959 5827
ERO1A 3643 -809
ETS1 -2368 4334
ETS2 -3941 1436
EZH2 4487 4485
FAU -4443 5991
FBXL17 -3428 4856
FKBP4 -1987 4677
FKBP5 389 1867
FLCN 1083 2472
FNIP1 3959 6015
FOS -3745 4083
FZR1 -1998 7430
GCN1 -144 7280
GPX1 -4408 2183
GRB10 -553 192
GSK3B -648 3637
GSR -3081 1990
GSTP1 -3395 6832
HDAC3 -2463 8308
HIF1A -446 4115
HIF1AN -3580 -320
HIGD1A 1475 4139
HIRA -1788 6286
HM13 -3720 1856
HMGA1 -3906 5560
HMOX2 -3873 704
HSBP1 715 1432
HSF1 -2825 5763
HSP90AA1 2910 4876
HSP90AB1 585 829
HSPA13 1858 4247
HSPA14 4622 7441
HSPA1A -3404 1113
HSPA1B 1982 755
HSPA1L -349 336
HSPA2 -2262 5784
HSPA4 1179 8237
HSPA4L 3248 7845
HSPA9 -588 5882
HSPH1 3950 3890
ID1 -4373 5853
ITFG2 2203 3363
JUN -2852 2775
KAT5 -1917 5607
KDM6B -1439 2846
KEAP1 -2853 5049
KPTN -2495 7869
LAMTOR1 -4490 -649
LAMTOR2 -4374 -288
LAMTOR3 3009 6767
LAMTOR4 -4140 1911
LAMTOR5 -3457 7083
LIMD1 970 2244
LMNB1 3532 4104
LRPPRC 1645 376
MAFK -2135 1829
MAP2K3 -3178 38
MAP2K4 569 3168
MAP2K6 2656 2172
MAP2K7 -3762 2099
MAP3K5 947 4831
MAP4K4 -1325 7027
MAPK1 -664 2770
MAPK14 -471 2235
MAPK3 -4544 -479
MAPK7 -1945 3019
MAPK8 -584 6176
MAPK9 -2019 1159
MAPKAPK2 -3852 1423
MAPKAPK3 -2308 58
MDM2 4685 1092
MDM4 3961 1115
MED1 884 5989
MEF2D -2928 4570
MINK1 -3981 2629
MIOS 268 3553
MLST8 -2698 3421
MOV10 4456 7640
MRPL18 87 3878
MTOR -2466 1240
NBN 3430 1983
NCF4 -3240 -141
NCOA2 2520 7322
NCOA6 1077 761
NCOR1 1467 1101
NCOR2 -3180 580
NDC1 1276 -274
NDUFA4 -2791 2018
NFE2L2 3859 5438
NLRP3 -1832 6403
NPRL2 -1141 5068
NPRL3 100 7970
NR1D1 -3155 5009
NR3C1 795 4250
NR3C2 -508 6632
NUDT2 -2712 6673
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
P4HB -3964 6831
PHC1 -3551 606
PHC2 -3417 4319
PHC3 3656 522
POM121 -1366 5167
POM121C -3196 5663
PPP1R15A -4074 5649
PRDX1 1389 4095
PRDX2 -2836 6462
PRDX3 1144 3939
PRDX5 -4506 7719
PRDX6 -3456 4160
PRKCD -1518 8196
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PTGES3 3489 2735
RAD50 4672 179
RAE1 1852 710
RAI1 -3348 7815
RANBP2 3105 4436
RB1 1147 1518
RBBP4 1636 2574
RBX1 776 6226
RELA -3471 5749
RHEB 2796 6691
RING1 -3885 4529
RNF2 2490 7500
RORA 524 7068
RPA1 -1575 8080
RPA3 956 1331
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS19BP1 -4498 1425
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS6KA1 -2403 6292
RPS6KA2 -1652 6457
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
RPTOR 308 -222
RRAGA -1598 8312
RRAGC 3286 7017
RRAGD -2441 3981
SCMH1 -3339 7093
SCO1 1765 2221
SCO2 2396 237
SEC13 -2693 7357
SEH1L 3110 6644
SERPINH1 -3383 1350
SESN1 -776 4595
SESN2 -263 1608
SIN3A -798 1529
SIN3B -604 -271
SIRT1 2340 6815
SKP1 2353 3193
SKP2 4608 3439
SLC38A9 1899 6434
SOD1 -1988 6467
SOD2 1499 6344
SP1 -1581 2146
ST13 -2058 6559
STAT3 1093 7085
STIP1 -2074 -119
SURF1 -1424 4051
SZT2 2031 935
TACO1 -4362 1969
TBL1XR1 1832 1367
TCIRG1 -2718 4563
TERF1 2606 5033
TERF2 2089 5105
TERF2IP -1882 7036
TFDP1 1708 471
TFDP2 -2800 3770
TINF2 -2823 4849
TNIK -398 4975
TNRC6A 4363 6086
TNRC6B 2494 787
TP53 -92 1992
TPR 3482 5135
TRIB3 1943 563
TXN -441 339
TXN2 -4048 5130
TXNIP 508 3975
TXNRD1 -917 214
TXNRD2 -3686 -152
UBA52 -4076 4404
UBB -3235 564
UBC -1858 2635
UBE2C -2854 1584
UBE2D1 273 4705
UBE2D2 -1452 4272
UBE2D3 1741 2455
UBE2E1 -754 3149
UBE2S 707 -550
UBN1 356 7888
VCP -3583 7877
VEGFA -3785 832
VHL -1931 2728
WDR24 -2267 2561
WDR59 -1010 7281
XPO1 4524 5628
YWHAE 431 6202



Neutrophil degranulation

Neutrophil degranulation
metric value
setSize 305
pMANOVA 3.8e-12
p.adjustMANOVA 1.7e-10
s.dist 0.242
s.RNA -0.24
s.meth -0.0264
p.RNA 8.35e-13
p.meth 0.433




Top 20 genes
Gene RNA meth
LAMTOR1 -4490 -649
AGA -4257 -404
PTGES2 -3345 -437
AGPAT2 -4267 -330
RAB7A -2395 -526
LAMTOR2 -4374 -288
LPCAT1 -2221 -422
PYGB -3255 -230
ATP8B4 -1498 -471
KCMF1 -973 -492
CD53 -840 -466
ILF2 -978 -352
NCSTN -617 -457
SERPINB1 -1145 -242
CTSZ -3678 -74
CAB39 -619 -207
IGF2R -3584 -23
CAT -305 -221

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -4540 7306
ACAA1 -2770 6285
ACLY -188 2355
ACTR10 1835 5133
ACTR1B -3707 3813
ACTR2 2174 4951
ADAM10 419 3603
ADAM8 -2930 7481
ADGRE5 -2016 2059
AGA -4257 -404
AGL 3703 2766
AGPAT2 -4267 -330
ALAD -3206 374
ALDOA -3406 648
ALDOC 482 7310
ALOX5 -1706 6147
AMPD3 -2600 4571
ANO6 -1694 7673
AP1M1 -4274 2151
APAF1 652 7539
APEH -3495 432
APRT -4487 7685
ARHGAP9 -3479 392
ARL8A -4365 136
ARMC8 1845 4280
ARPC5 804 2343
ARSA 1157 -585
ARSB 809 6874
ASAH1 1480 3500
ATAD3B -1912 5589
ATG7 -2328 1263
ATP11A -1098 5484
ATP11B 1720 -214
ATP6V0A1 -1930 5542
ATP6V0C -2681 2508
ATP6V1D 1060 449
ATP8A1 591 -197
ATP8B4 -1498 -471
B2M 2830 3658
B4GALT1 -2892 7957
BIN2 -3333 3315
BRI3 -2882 3769
BST2 2756 -711
C3AR1 4556 1729
C6orf120 -657 7911
CAB39 -619 -207
CAND1 2776 1732
CAP1 -1431 5579
CAPN1 -3796 5491
CAT -305 -221
CCT2 1073 3456
CCT8 -833 2010
CD300A 3363 -870
CD44 -2857 4410
CD47 3677 2452
CD53 -840 -466
CD55 -810 3298
CD58 2863 5830
CD59 -2407 4486
CD63 -4429 7202
CDK13 146 5488
CEACAM1 1921 827
CEP290 4649 7343
CKAP4 -2260 8317
CMTM6 2761 4088
CNN2 -556 2041
COMMD3 1824 611
COMMD9 -558 85
COPB1 2725 2901
COTL1 -812 2431
CPNE1 -3328 4825
CPNE3 291 2510
CPPED1 -295 5767
CREG1 -3823 1570
CSNK2B -1331 7503
CSTB -1654 6923
CTSA -3502 2093
CTSB -2639 7080
CTSC 738 2318
CTSD -4228 8435
CTSS 1234 -510
CTSZ -3678 -74
CYB5R3 -3770 4999
CYBA -3513 5379
CYFIP1 -2919 8327
CYSTM1 -2383 7328
DBNL -3926 2976
DEGS1 -1251 4801
DERA 2361 7436
DGAT1 -3596 6449
DIAPH1 -990 5138
DNAJC13 3301 210
DNAJC3 1878 8319
DNAJC5 -3733 3123
DPP7 -4248 7270
DSN1 4114 2710
DYNC1H1 -621 1172
DYNC1LI1 2931 6081
DYNLL1 -1533 5391
DYNLT1 2338 4678
EEF1A1 -4059 2014
EEF2 -4461 1316
ENPP4 998 1345
ERP44 2658 127
FABP5 761 3670
FAF2 -679 7657
FGR -2747 6452
FTH1 -2381 3732
FTL -2022 3971
FUCA1 -3588 2333
FUCA2 260 619
GAA -3165 1089
GALNS -1700 6572
GCA 1117 2709
GDI2 1939 7902
GGH 1578 6724
GHDC -3293 2859
GLB1 -1934 7211
GLIPR1 997 393
GM2A -23 6425
GMFG -2851 6341
GNS -638 5474
GOLGA7 880 3423
GPI -3307 6596
GRN -2095 3090
GSDMD -2430 4189
GSTP1 -3395 6832
GUSB -2990 4887
GYG1 -3201 6468
HEBP2 -2292 5581
HEXB -1501 7586
HGSNAT -323 355
HLA-A -4258 2274
HLA-B -1024 513
HLA-C -217 6790
HLA-H -4103 7849
HMGB1 981 2532
HMOX2 -3873 704
HSP90AA1 2910 4876
HSP90AB1 585 829
HSPA1A -3404 1113
HSPA1B 1982 755
HVCN1 -1080 1434
IDH1 2514 3293
IGF2R -3584 -23
ILF2 -978 -352
IMPDH1 -2518 6
IMPDH2 -4240 5354
IQGAP1 -1470 375
IQGAP2 1280 2780
IST1 971 1933
ITGAL -224 4422
ITGAV 805 3287
ITGB2 -4278 750
KCMF1 -973 -492
KCNAB2 -4227 5929
KPNB1 3755 5921
LAIR1 -1241 6753
LAMP1 -4288 7982
LAMTOR1 -4490 -649
LAMTOR2 -4374 -288
LAMTOR3 3009 6767
LPCAT1 -2221 -422
LTA4H -792 5719
MAN2B1 -3851 7279
MANBA 2201 4780
MAPK1 -664 2770
MAPK14 -471 2235
MIF -3978 2447
MLEC -1044 5334
MMP25 -42 6417
MNDA 2315 1449
MPO -3624 347
MVP -2199 8026
NAPRT 94 -73
NBEAL2 -1618 5626
NCKAP1L 731 1935
NCSTN -617 -457
NDUFC2 -3896 5333
NEU1 -270 3069
NHLRC3 4564 5893
NIT2 3035 1160
NME2 -569 1739
NPC2 407 6368
ORMDL3 -375 2581
OSCAR 1095 2321
OSTF1 -1276 7552
P2RX1 1242 2776
PA2G4 913 2838
PAFAH1B2 1055 4504
PDAP1 -4316 8125
PDXK -3053 4973
PFKL -3642 23
PGAM1 -3977 1593
PGM1 -3725 4577
PGM2 -1834 3355
PKM -3743 1481
PLAC8 1529 3818
PLAU -3032 5301
PLAUR -1591 4328
PLD1 106 2196
PLEKHO2 -433 6305
PNP 1599 2166
PPIA -2974 5622
PPIE 2119 6766
PRCP -1258 6367
PRDX6 -3456 4160
PRKCD -1518 8196
PRTN3 -4397 8385
PSAP -1274 1290
PSEN1 1406 1724
PSMA2 -822 4948
PSMA5 1789 4192
PSMB1 -2719 2993
PSMB7 -4334 1594
PSMC3 -3682 4698
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD6 -155 3184
PSMD7 1088 871
PTGES2 -3345 -437
PTPN6 -353 2545
PTPRC 3435 1766
PTPRJ -2585 6883
PTPRN2 -1403 1646
PYCARD -2341 3155
PYGB -3255 -230
QPCT -2208 1848
QSOX1 -4014 6811
RAB10 485 1029
RAB14 2975 1868
RAB18 3153 1168
RAB24 1856 260
RAB27A 1452 7285
RAB37 1031 7555
RAB3A -3984 3520
RAB3D -1802 5964
RAB4B -2921 7798
RAB5B -1974 1215
RAB5C -4148 2996
RAB6A 2540 6447
RAB7A -2395 -526
RAC1 1432 7511
RAP1A 3605 2618
RAP1B 2528 6154
RAP2B -802 6584
RHOA -152 1886
RHOF -1515 3524
RHOG -3137 3983
RNASET2 -1268 737
ROCK1 3813 2216
S100A11 -778 3968
S100P -3074 632
SCAMP1 2211 7830
SDCBP 183 7446
SERPINB1 -1145 -242
SERPINB6 -4001 8005
SLC11A1 -651 1284
SLC15A4 2252 -651
SLC27A2 4187 3284
SLC2A3 -2809 4149
SLC44A2 -3167 1456
SLCO4C1 2126 1680
SNAP23 1502 8001
SNAP29 -3994 6080
SPTAN1 -2478 372
SRP14 428 5822
STBD1 -811 6139
STK10 -2343 3483
STK11IP -4039 4548
STOM 531 -764
SURF4 -3281 5239
SVIP 1816 4144
TBC1D10C -3824 3156
TCIRG1 -2718 4563
TLR2 1473 6797
TMBIM1 -3833 2141
TMC6 -1264 1587
TMEM179B -614 1551
TMEM30A 1804 7713
TMEM63A 1468 1374
TNFRSF1B -2234 1257
TOLLIP -4034 1238
TOM1 -4294 5194
TRAPPC1 -2838 4015
TRPM2 -3545 7785
TSPAN14 -1761 924
TUBB -254 3715
TUBB4B -1808 6419
TXNDC5 3742 7527
TYROBP -3335 835
UNC13D -2842 484
VAMP8 -4404 3389
VAPA 246 3839
VAT1 -4168 1433
VCL -2203 1837
VCP -3583 7877
XRCC5 475 3525
XRCC6 -2419 2815
YPEL5 1584 -147



Metabolism

Metabolism
metric value
setSize 1216
pMANOVA 5.1e-12
p.adjustMANOVA 2.2e-10
s.dist 0.13
s.RNA -0.125
s.meth 0.0345
p.RNA 1.92e-12
p.meth 0.0519




Top 20 genes
Gene RNA meth
UQCR11 -4398 8422
NDUFB2 -4385 8398
TSPO -4236 8436
ARF1 -4250 8404
MCAT -4482 7952
ADCY9 -4217 8419
APRT -4487 7685
RPS12 -4451 7699
RPL8 -4481 7647
POR -4205 8126
TRMT112 -4331 7797
PTPN13 -4025 8368
NDUFB1 -4259 7880
B3GNT7 -4107 7920
RPL18 -4194 7741
RPL36AL -4421 7261
SLC27A1 -4439 7218
NME4 -4112 7769
GNA15 -4450 7123
GALE -3789 8229

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
AACS -1456 6880
AANAT 1657 7396
ABCA1 -3141 7256
ABCC1 1685 1830
ABCC5 -2923 4067
ABCD4 -1494 5999
ABHD10 3716 -11
ABHD14B -2830 1280
ABHD3 4390 4066
ABHD4 -3472 4788
ABHD5 2466 725
ACAA1 -2770 6285
ACACA -369 4853
ACACB 2699 5505
ACAD10 2346 2202
ACAD11 4232 2786
ACADM 3658 2050
ACADS -4174 3068
ACADSB 2458 8307
ACAT1 1601 5751
ACAT2 381 2839
ACBD4 224 1771
ACBD5 1946 6093
ACBD6 -3517 6484
ACBD7 2839 6321
ACER2 4 662
ACER3 1551 4478
ACLY -188 2355
ACOT13 4517 3384
ACOT7 -2637 7608
ACOT8 -1302 3844
ACOX1 1891 4680
ACOX3 -112 2168
ACOXL 3804 -167
ACP5 -616 4060
ACP6 -1065 6955
ACSF2 4014 8270
ACSF3 -756 4841
ACSL1 -307 4204
ACSL3 2609 2017
ACSL5 2654 -554
ACSL6 -453 -645
ACSM1 27 7384
ACSM3 1141 7968
ACSS1 -4271 2746
ACSS2 -779 4802
ACY1 -1455 4493
ADA 244 5136
ADAL 4537 6033
ADCY4 757 6234
ADCY7 -1798 2400
ADCY9 -4217 8419
ADH5 -2525 7584
ADHFE1 2956 1107
ADIPOR1 -337 5777
ADIPOR2 -3231 4928
ADK 832 4459
ADO 536 6026
ADPGK 2655 2260
ADSL -2336 2551
AFMID 3535 1182
AGK 2275 6036
AGL 3703 2766
AGMAT 3091 113
AGPAT1 -3266 6647
AGPAT2 -4267 -330
AGPAT3 1462 -474
AGPAT4 35 5536
AGPAT5 3064 2583
AGPS 2732 3792
AGRN 3879 3516
AHCY -4145 1896
AHCYL1 331 6911
AHR -3173 397
AHRR -3499 791
AIMP2 -491 6011
AIP -4091 1501
AK2 141 3226
AK9 1918 -828
AKR1A1 -2369 4797
AKR1B1 -4037 2326
AKR7A2 -4325 6342
AKT1 -4078 4230
ALAD -3206 374
ALDH18A1 -1157 6062
ALDH1B1 -652 7591
ALDH3A2 2439 7674
ALDH4A1 -3988 3158
ALDH6A1 470 335
ALDH9A1 -399 6692
ALDOA -3406 648
ALDOC 482 7310
ALOX5 -1706 6147
ALOX5AP -1825 3573
AMACR -634 7571
AMD1 3688 1679
AMDHD1 -1093 7850
AMPD2 -3068 6590
AMPD3 -2600 4571
APRT -4487 7685
ARF1 -4250 8404
ARF3 -3660 4378
ARG2 383 5936
ARNT 928 5016
ARNTL 621 5761
ARSA 1157 -585
ARSB 809 6874
ARSG 1822 6628
ARSK -1378 5180
ARV1 4261 8102
ASAH1 1480 3500
ASL -2180 7724
ASNS 2780 2242
ASRGL1 -1827 4268
ATIC 1603 5012
AUH 231 1233
AZIN1 295 202
AZIN2 -1187 711
B3GALT4 -2633 5384
B3GALT6 -3557 7118
B3GAT2 -409 7818
B3GAT3 -3620 5844
B3GNT2 3985 6205
B3GNT7 -4107 7920
B4GALT1 -2892 7957
B4GALT2 298 -162
B4GALT3 1504 2276
B4GALT4 271 4038
B4GALT5 209 5443
B4GALT6 -2272 5500
B4GALT7 -1253 5460
B4GAT1 -3374 805
BCAT1 226 3114
BCAT2 -1179 2278
BCKDHA -4290 3276
BCKDHB 4606 1441
BCKDK -3363 -102
BDH1 -339 7874
BDH2 3404 1524
BLVRA 3894 8206
BLVRB -4155 2113
BPHL 2232 4158
BPNT1 -220 -312
BRIP1 3528 5492
BSG -4161 758
BTD 36 3162
CA13 1779 6746
CA6 3401 407
CACNA1C -2576 3128
CACNA2D2 1 -615
CACNB3 -1094 4217
CAD 55 2219
CALM1 1471 3996
CARNMT1 2688 1640
CARNS1 -431 4453
CAV1 2411 7738
CBR3 -1695 6694
CBR4 2985 7307
CCNC 3746 2192
CD320 -968 1192
CD38 3060 672
CD44 -2857 4410
CDIPT -4367 1924
CDK19 44 749
CDK8 2703 2327
CDS2 -2827 5891
CEPT1 3620 852
CERK -4203 -373
CERS5 2897 5437
CERS6 -886 4254
CES2 -1225 -738
CHAC2 2510 3031
CHD9 1137 6134
CHKA 225 6951
CHKB 887 -26
CHP1 -2763 624
CHPF -533 5678
CHPF2 -3681 5473
CHPT1 912 -368
CHST11 -3315 2817
CHST12 1583 6327
CHST14 -2833 4687
CHST2 -3908 4950
CHSY1 -438 1619
CIAO1 -1569 5605
CIAPIN1 -2978 7962
CKB -1975 6935
CLOCK 3411 6485
CMBL 2533 6744
CMPK1 -444 8216
CNDP2 -35 4227
COA1 2071 8256
COASY -2701 984
COMT -4115 -295
COQ10A 467 7736
COQ10B 2636 5769
COQ2 -326 3061
COQ3 492 3730
COQ5 3034 3244
COQ6 3039 3358
COQ7 838 3334
COQ9 195 4557
COX10 -415 4653
COX11 2934 3025
COX14 -3473 3855
COX15 548 2067
COX16 3674 3560
COX19 3545 298
COX20 3562 3497
COX4I1 -3349 4535
COX5A -3813 3397
COX5B -3992 -244
COX6A1 -4298 1809
COX6B1 -2925 2356
COX6C -2174 2408
COX7A2L -489 5803
COX7C -3932 603
COX8A -4207 3949
CPNE1 -3328 4825
CPNE3 291 2510
CPOX -2801 6001
CPS1 2485 -256
CPT1A -1009 24
CPT2 3594 4055
CPTP -2465 8339
CRAT -4052 6522
CREBBP -2131 6830
CRLS1 -422 3907
CRYL1 -2874 1437
CRYM -545 4980
CS 126 3697
CSAD 1308 3086
CSGALNACT1 -1621 1521
CSGALNACT2 3709 323
CSNK1G2 -4176 6824
CSNK2A2 1126 3957
CSNK2B -1331 7503
CTH 3759 1184
CTPS1 3415 2542
CTSA -3502 2093
CYB5A 3895 5968
CYB5B 2461 3877
CYB5R3 -3770 4999
CYC1 -3882 5829
CYCS 2102 2450
CYP2R1 3521 4409
CYP2U1 3692 3610
CYP46A1 4702 1277
CYP4F22 4545 -386
CYP4V2 -2083 6671
CYP51A1 3547 2962
D2HGDH 653 2389
DBI -4126 594
DBT 4728 1175
DCK 2167 4947
DCTD 41 3972
DCTPP1 -2342 3205
DCXR -1585 991
DDAH2 -3970 5773
DDHD1 3575 8242
DDHD2 2955 4728
DECR1 4211 2646
DECR2 -1869 4479
DEGS1 -1251 4801
DERA 2361 7436
DGAT1 -3596 6449
DGAT2 -1996 6848
DGUOK -470 7474
DHCR24 3436 2371
DHCR7 -546 6464
DHFR 1352 224
DHODH -596 -456
DHRS7B -1923 2471
DHTKD1 4572 4620
DLAT 944 1054
DLD 1996 4527
DLST -3161 7228
DNM2 -3963 6605
DPEP2 -14 5071
DPYD -1740 1333
DSE -2674 3771
DSEL 932 6534
DTYMK 82 5494
DUT -3423 4927
ECHS1 -1979 4579
ECI1 -4095 5925
ECI2 -167 932
ECSIT -3238 6323
EEF1E1 1868 3266
EEFSEC -1190 6233
EHHADH 4017 8240
ELOVL1 -2473 8077
ELOVL4 -3676 7748
ELOVL5 1516 4258
ELOVL6 -2523 3278
ENO1 -3898 3952
ENO2 1370 5074
ENO3 -2663 8383
ENOPH1 -3474 4057
ENPP2 3849 7490
ENTPD1 256 7155
ENTPD4 2815 502
ENTPD5 4492 3843
ENTPD6 -3938 4882
ENTPD7 1205 5490
EP300 1012 3364
EPHX1 -1312 7459
EPHX2 940 2683
ERCC2 -1586 1785
ESD 945 4779
ESRRA -3204 5928
ESYT1 -823 4185
ESYT2 -2526 2998
ETFA 2927 5795
ETFB -3171 3419
ETFDH 3116 7626
ETHE1 -4488 804
ETNK1 4528 7541
EXT1 -504 7581
EXT2 -1332 7940
FABP5 761 3670
FADS1 3346 7444
FADS2 361 4029
FAH -4018 526
FAHD1 -919 2894
FAM120B 4683 7550
FAR1 2657 4799
FASN -3111 3300
FAU -4443 5991
FBP1 -1379 6919
FDFT1 -1375 6829
FDPS -3177 3904
FDX1 2921 5894
FDXR 1028 3311
FECH 622 1301
FH 391 1302
FIG4 1522 5966
FITM2 1120 1675
FLAD1 -2856 7717
FLVCR1 4319 7622
FPGS -3575 7949
FUT10 563 5277
FUT11 2341 6318
FUT4 -2128 5273
FXN 1066 5459
G6PC3 -2125 5378
GAA -3165 1089
GALC 623 2777
GALE -3789 8229
GALK1 -3768 1849
GALT 116 3231
GAPDH -4297 1138
GBA -2458 3514
GBA2 -2331 8316
GCDH -4546 937
GCH1 4631 6722
GCHFR -4366 5217
GCLC 3768 2282
GCLM -726 1772
GCSH 2230 8071
GDE1 -885 7351
GDPD1 385 4241
GDPD5 636 4443
GGCT 4031 337
GGPS1 4399 4472
GGT1 -3229 -730
GGT7 -2391 7229
GLB1 -1934 7211
GLCE -1910 6213
GLIPR1 997 393
GLO1 2191 1953
GLRX -1843 -480
GLRX5 -612 1567
GLS 4154 572
GLTP -3120 7934
GLUD1 -1031 5206
GLUL -1223 7319
GLYCTK -1642 6569
GM2A -23 6425
GMPR 2665 2820
GMPR2 -2973 5774
GMPS 2039 7984
GNA15 -4450 7123
GNAI2 -3426 5421
GNAQ 779 3831
GNAS -2079 -276
GNB1 -2758 -391
GNB2 -2980 6049
GNB4 3395 8172
GNB5 373 5796
GNG2 92 4290
GNG3 4104 8393
GNG4 3296 7006
GNG5 -204 3751
GNG7 619 -475
GNGT2 -1460 -71
GNPDA1 -2461 2317
GNPDA2 1062 2466
GNS -638 5474
GOT1 2542 4943
GOT2 463 1040
GPAM 2199 3283
GPC2 -1960 5692
GPCPD1 1808 7416
GPD1 480 2281
GPD1L 250 6949
GPD2 2752 4786
GPHN -1634 7859
GPI -3307 6596
GPS2 -1042 1242
GPT2 4321 6335
GPX1 -4408 2183
GPX4 -3261 5345
GRHPR -1126 1385
GSR -3081 1990
GSS -2750 7383
GSTA4 4575 1574
GSTK1 1671 1001
GSTM3 3298 3582
GSTM4 1441 4532
GSTO1 -2143 7246
GSTO2 522 3218
GSTP1 -3395 6832
GSTZ1 849 2248
GUK1 -2694 4350
GUSB -2990 4887
GYG1 -3201 6468
GYS1 -1743 4356
HACD1 4152 8407
HACD2 734 8176
HACD3 2065 8213
HACD4 1217 -111
HACL1 1940 3208
HADH -805 5854
HADHA -3698 7301
HADHB -1107 2687
HAGH -2668 5119
HDAC3 -2463 8308
HEXA -3270 6940
HEXB -1501 7586
HIBADH 2440 -309
HIBCH 4500 7161
HILPDA 3205 6194
HK1 -3121 2185
HK2 -3614 1526
HLCS 1677 402
HMBS 113 5610
HMGCL 1710 477
HMGCR 615 4936
HMGCS1 4181 7150
HMMR 816 3599
HMOX2 -3873 704
HPD 4337 4383
HPGD 3473 8390
HS3ST3B1 -1727 8081
HS6ST1 -2841 1462
HSCB -1836 7125
HSD17B1 -1790 953
HSD17B11 1300 1203
HSD17B12 542 2579
HSD17B4 -385 2703
HSD17B8 1440 1503
HSP90AA1 2910 4876
HSP90AB1 585 829
HYAL1 3808 -580
HYAL2 -3972 2095
HYAL3 -1535 3787
IDH1 2514 3293
IDH2 773 8195
IDH3A 3336 236
IDH3B -2704 4119
IDI1 3655 5283
IDUA -2710 7884
IL4I1 -2435 -346
IMPA1 4115 3575
IMPA2 -4410 4892
IMPDH1 -2518 6
IMPDH2 -4240 5354
INPP1 -2529 4121
INPP4A -1684 2953
INPP5A -2586 773
INPP5B 2808 5593
INPP5D -3006 1167
INPP5E -389 6674
INPP5F 3940 500
INPP5K -123 5499
INPPL1 -2977 7291
INSIG1 4589 -623
INSIG2 2438 4623
IP6K1 -3625 6478
IP6K2 590 7313
IPMK 1794 48
IPPK -68 3195
IQGAP1 -1470 375
ISCA1 -816 4007
ISCU 903 -138
ITPA -2554 5915
ITPK1 -2798 7094
ITPKB -2994 1876
ITPKC -2944 2812
ITPR1 918 6634
ITPR2 2226 4474
ITPR3 643 2887
IVD 1193 963
KCNJ11 -741 -427
KHK -2670 -50
KMO 3239 2433
KPNB1 3755 5921
L2HGDH 3577 1163
LBR 766 84
LCLAT1 3379 4627
LDHA -257 7452
LDHB -740 5282
LDLR 4178 3933
LGMN -1739 6394
LHPP -1645 676
LIAS 4299 6063
LIPE -498 7854
LIPT1 4262 7533
LIPT2 -1469 5908
LMBRD1 1666 1143
LPCAT1 -2221 -422
LPCAT3 -2081 2871
LPCAT4 -505 3722
LPGAT1 -275 4551
LPIN1 3147 5878
LPIN2 1791 5561
LRP10 -2380 1836
LRP12 -1563 8362
LRP8 -676 2507
LRPPRC 1645 376
LSS -1294 2493
LTA4H -792 5719
LTC4S -4395 5108
LYPLA1 2159 1207
LYRM4 -3496 766
MAN2B1 -3851 7279
MAN2B2 1485 6921
MAN2C1 -1928 4905
MANBA 2201 4780
MAPKAPK2 -3852 1423
MAT2A -2454 8062
MAT2B 3431 4880
MBOAT1 1611 5227
MBOAT7 -2094 2661
MBTPS1 946 2406
MCAT -4482 7952
MCCC1 -396 8183
MCCC2 4610 5255
MCEE 4158 5597
MDH1 153 5775
MDH2 -3673 -832
ME2 4483 1890
ME3 -3782 3966
MECR -695 4523
MED1 884 5989
MED10 -687 437
MED11 -994 2732
MED13 -548 6657
MED13L 1724 3819
MED15 -643 637
MED16 -3391 6781
MED17 2715 1178
MED18 987 -582
MED19 280 269
MED20 -1924 3815
MED21 3727 7649
MED22 -4101 6196
MED23 3644 2535
MED24 -2511 4354
MED25 -750 5856
MED26 -3998 4987
MED27 -707 2243
MED28 3571 6056
MED29 -2077 3182
MED30 -1894 1820
MED31 4533 8039
MED4 2210 1156
MED6 4248 7020
MED7 4219 451
MED8 1107 5186
MED9 -65 4035
MFSD2A -1952 2961
MGST2 -1758 7137
MGST3 1598 494
MINPP1 267 3856
MLX -1771 6614
MLYCD 3178 6227
MMAA 4465 2913
MMAB 1052 3567
MMACHC 2697 -173
MMADHC 3231 4922
MMS19 -1297 4226
MOCOS 597 2158
MOCS2 2847 7896
MOCS3 -2196 842
MORC2 905 2368
MPC2 -3147 1469
MPST -4491 6640
MSMO1 4570 4674
MTAP 3017 8057
MTF1 1105 2958
MTHFD1 1377 732
MTHFD1L 3889 53
MTHFD2 2986 7457
MTHFR 1337 7272
MTHFS -976 2616
MTMR10 2139 8298
MTMR12 -56 -115
MTMR14 -2230 512
MTMR2 2041 7226
MTMR3 -3340 255
MTMR4 1896 4191
MTMR6 2205 745
MTMR9 4179 5025
MTR 2390 3011
MTRR 3249 5670
MVD -3546 8431
MVK 1833 6710
N6AMT1 1750 326
NADK 247 5341
NADK2 -857 -300
NADSYN1 -1028 6645
NAGLU -3759 7426
NAGS -4054 5040
NAMPT 2605 5169
NAPRT 94 -73
NAT1 4576 6952
NCOA2 2520 7322
NCOA3 3929 6898
NCOA6 1077 761
NCOR1 1467 1101
NCOR2 -3180 580
NDC1 1276 -274
NDST2 -2442 -263
NDUFA10 -420 5793
NDUFA11 -2905 601
NDUFA12 -535 729
NDUFA13 -4479 5091
NDUFA2 -4444 3313
NDUFA3 -3482 7304
NDUFA4 -2791 2018
NDUFA5 3596 333
NDUFA6 -2212 4184
NDUFA7 -3515 2639
NDUFA8 -192 5072
NDUFA9 3168 7361
NDUFAB1 -2579 1043
NDUFAF1 2034 426
NDUFAF2 233 2075
NDUFAF3 -3892 1824
NDUFAF4 429 -161
NDUFAF5 -382 -133
NDUFAF6 3389 -482
NDUFB1 -4259 7880
NDUFB10 -4300 4926
NDUFB2 -4385 8398
NDUFB3 -1941 5110
NDUFB4 -2457 1638
NDUFB5 2482 3909
NDUFB7 -4010 4869
NDUFB9 -4179 4749
NDUFC1 -1837 2107
NDUFC2 -3896 5333
NDUFS1 229 -31
NDUFS2 -1914 57
NDUFS3 -3323 193
NDUFS4 128 6272
NDUFS5 -3876 5637
NDUFS6 -4343 6204
NDUFS7 -3319 5729
NDUFS8 -4040 102
NDUFV1 -3154 4359
NDUFV2 770 1025
NDUFV3 -966 6531
NEU1 -270 3069
NEU3 -2101 5695
NFYA 47 2644
NFYB 2140 7873
NFYC -552 3129
NHLRC1 -2426 6568
NME1 -2531 790
NME2 -569 1739
NME3 -4511 5035
NME4 -4112 7769
NMNAT1 -2626 4865
NMNAT3 -1857 5145
NMRAL1 -2997 6966
NMRK1 2631 -418
NNT 1183 7324
NOS3 301 4054
NOSIP -835 358
NQO1 -2832 4198
NQO2 1457 5302
NR1D1 -3155 5009
NR1H2 -3373 7088
NR1H3 -3834 8069
NRF1 -3123 6265
NT5C -2069 422
NT5C2 3820 7558
NT5C3A 2896 488
NT5M -2717 3412
NUBP1 -2605 2167
NUBP2 -3909 4755
NUDT1 -4509 6754
NUDT12 2700 8286
NUDT13 3399 931
NUDT15 4255 3385
NUDT16 -3005 8333
NUDT18 -1806 7781
NUDT19 491 479
NUDT3 -1227 1514
NUDT4 3081 354
NUDT5 167 1778
NUDT7 2239 4565
NUDT9 -1140 4255
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
OAT 1924 329
OAZ1 -4127 6795
OAZ2 -1995 7617
OAZ3 1225 3936
ODC1 -511 6387
OGDH -1954 1499
ORMDL1 3329 7689
ORMDL3 -375 2581
OSBP 831 3085
OSBPL2 782 3724
OSBPL3 504 1671
OSBPL5 -2595 7435
OSBPL7 577 1402
OSBPL8 1436 6582
OSBPL9 1775 3434
OXCT1 2402 3322
PAICS 2667 3791
PANK1 -317 391
PANK2 1801 7498
PANK3 1676 4242
PANK4 -2538 410
PAOX -1921 -784
PAPSS1 446 6222
PARP10 4138 249
PARP14 4751 288
PARP16 -2060 3444
PARP4 3939 2826
PARP6 -577 7359
PARP8 1448 -314
PARP9 4759 3387
PC -4364 1255
PCBD1 -2499 8417
PCCB -2023 3538
PCK2 1840 3678
PCTP -2667 8320
PCYT1A 3737 5851
PCYT2 -2491 6152
PDHB 1229 6538
PDHX 1149 5278
PDK1 2818 4264
PDK2 -3353 5794
PDP1 4006 7003
PDP2 2930 1958
PDPR 2562 1098
PDSS1 3891 1055
PDSS2 872 -37
PDXK -3053 4973
PECR -3091 4694
PEMT -486 6770
PEX11A 445 343
PFAS -3222 5204
PFKFB2 1127 7652
PFKFB3 -2252 5953
PFKFB4 -2009 5420
PFKL -3642 23
PFKM -1897 6978
PFKP -1623 246
PGAM1 -3977 1593
PGD -3859 4560
PGLS -4388 3410
PGM1 -3725 4577
PGM2 -1834 3355
PGM2L1 -297 7574
PGP -4249 4732
PGS1 -3267 126
PHGDH 4113 6806
PHKB 3424 2
PHKG2 -1343 748
PHOSPHO1 1936 6821
PHYKPL 909 -693
PI4K2A -2372 524
PI4K2B 4743 2571
PI4KA -2197 4522
PI4KB -550 4394
PIAS4 -2955 7610
PIK3CA 2842 3290
PIK3CD -2911 153
PIK3CG 758 2565
PIK3R1 -2375 5157
PIK3R2 -1983 5365
PIK3R3 3664 3533
PIK3R4 2129 2082
PIK3R5 -3304 1803
PIKFYVE 2586 428
PIP4K2A -2400 5449
PIP4K2B -3175 1209
PIP4K2C 894 5957
PIP5K1A 1181 3950
PIP5K1C -3773 8050
PISD -2644 -204
PITPNB 4217 4452
PITPNM1 -2294 98
PITPNM2 1330 -196
PITPNM3 2198 8239
PKM -3743 1481
PLA2G12A -1062 7706
PLA2G15 -1631 3464
PLA2G4C -3087 1022
PLA2G6 -2398 2570
PLB1 -3849 2634
PLCB2 -2432 3659
PLCB3 -3133 6207
PLCD1 -1516 4941
PLCD3 -4049 5541
PLCG1 345 5809
PLCG2 239 6178
PLD1 106 2196
PLD3 -2683 2245
PLD6 -2346 2922
PLEKHA2 881 1920
PLEKHA3 3788 8429
PLEKHA6 858 4193
PLEKHA8 1590 1512
PLIN2 -2709 4612
PLIN3 -4047 4583
PMVK -3109 3761
PNP 1599 2166
PNPLA2 -3761 8260
PNPLA6 -2425 5863
PNPLA7 2183 2898
PNPLA8 2385 6737
PNPO 1318 1278
PODXL2 -2163 5724
POLD1 -2967 753
POM121 -1366 5167
POM121C -3196 5663
PON2 -1487 3937
POR -4205 8126
PPA1 1586 5
PPA2 2838 5436
PPARD -2714 4461
PPARGC1B 1069 -746
PPCDC 2355 1709
PPCS 2886 2334
PPIP5K2 3350 5913
PPM1K 4695 3255
PPM1L -3225 3626
PPOX -1744 6218
PPP1CA -3185 1926
PPP1CB 2999 -226
PPP1CC 3626 3213
PPP2CA -120 7715
PPP2CB 1948 15
PPP2R1B 2397 612
PPP2R5D -853 5740
PPT1 1737 3100
PPT2 -2144 1907
PRKAB2 395 4064
PRKACA -2849 3985
PRKACB 1232 7740
PRKAG2 3104 5997
PRKAR1A 538 3914
PRKAR1B -2289 -687
PRKAR2A -142 532
PRKCA -2013 8000
PRKD2 2316 6896
PSAP -1274 1290
PSAT1 4288 3577
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PSPH 3508 5960
PSTK 1474 7792
PTDSS2 -2261 268
PTEN 1170 3667
PTGES2 -3345 -437
PTGES3 3489 2735
PTGR1 787 7941
PTGR2 -543 3004
PTPMT1 24 6661
PTPN13 -4025 8368
PTS 2165 7876
PXMP2 1026 1966
PYCR2 -4468 1819
PYGB -3255 -230
QDPR 3868 154
QPRT 1719 -863
RAB14 2975 1868
RAB4A -2037 2862
RAB5A 3764 1760
RAE1 1852 710
RAN 136 2287
RANBP2 3105 4436
RAP1A 3605 2618
RDH11 926 3749
RETSAT 830 6236
RFK 3158 6964
RGL1 1533 941
RIMKLB -1087 7026
RNLS 1216 3150
RORA 524 7068
RPE 1456 4886
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
RRM1 2290 4009
RRM2 1604 5483
RRM2B 3782 3044
RTEL1 -827 3440
RUFY1 -1060 1443
SACM1L 3214 4322
SAMD8 3291 4000
SAMHD1 3450 7360
SAR1B 4688 8006
SARDH -3440 8313
SBF1 -1328 5826
SC5D 4636 5876
SCAP -3116 618
SCD 3312 4092
SCLY -529 681
SCO1 1765 2221
SCO2 2396 237
SCP2 825 8334
SDC4 -3045 2476
SDHA -2650 6868
SDHB -1475 3928
SDHC -3136 4014
SEC13 -2693 7357
SEC23A 2282 6291
SEC24A 2856 2029
SEC24B 2676 7049
SEC24C -860 909
SEC24D 2306 6676
SEH1L 3110 6644
SEPHS2 -2130 4134
SERINC1 1510 307
SERINC3 134 2970
SERINC4 2333 -52
SERINC5 -2682 3136
SGMS1 670 6179
SGPL1 -1544 -159
SGPP1 4260 3679
SHMT1 105 4297
SHMT2 -268 793
SHPK 131 6422
SIN3A -798 1529
SIN3B -604 -271
SLC16A1 2318 3079
SLC16A3 -3224 2641
SLC19A1 -3554 8356
SLC19A2 88 6918
SLC22A5 -3287 8258
SLC23A1 4257 1930
SLC25A1 -2860 4305
SLC25A11 -3194 3449
SLC25A12 1076 2412
SLC25A13 305 7294
SLC25A15 -1933 1269
SLC25A16 4078 3858
SLC25A17 611 2283
SLC25A19 -962 3956
SLC25A20 -1269 3425
SLC25A28 2916 3263
SLC25A32 4554 1396
SLC25A37 1616 870
SLC25A44 21 5950
SLC26A2 323 7114
SLC27A1 -4439 7218
SLC27A2 4187 3284
SLC27A3 -1230 -468
SLC27A5 572 -515
SLC2A1 -1237 2227
SLC2A3 -2809 4149
SLC35B2 -3696 3060
SLC35B3 2593 875
SLC35D1 -856 8003
SLC36A4 1284 1392
SLC37A1 -136 -635
SLC37A2 -2843 6125
SLC37A4 243 2578
SLC3A2 -3776 497
SLC44A1 -164 3793
SLC44A2 -3167 1456
SLC5A5 -131 1265
SLC5A6 -1327 7996
SLC7A5 -709 -652
SLC9A1 -2736 996
SMPD1 -3318 5398
SMPD2 -4372 6627
SMPD3 180 700
SORD 706 4528
SP1 -1581 2146
SPHK2 -3769 6536
SPTLC1 2033 5902
SPTLC2 466 7826
SPTLC3 3734 822
SPTSSA 444 8188
SQLE 3773 5917
SRD5A1 1985 6836
SRD5A3 2902 2425
SREBF1 -2440 5382
SREBF2 325 3407
SRM -2716 3333
ST3GAL1 -2314 5875
ST3GAL2 -2611 2056
ST3GAL3 -1465 3508
ST3GAL4 -3567 2599
ST3GAL6 1909 8424
ST6GALNAC6 184 -547
STARD10 -3421 6296
STARD3 -4062 5403
STARD3NL -787 1126
STARD4 4582 3269
STARD5 -3029 642
STARD7 1761 6875
STK11 -3533 2662
STX1A -2317 1045
STXBP1 -2820 8426
SUCLA2 2337 4105
SUCLG1 190 6785
SUCLG2 2138 5852
SUMF1 -1550 2160
SUMF2 -539 105
SURF1 -1424 4051
SYNJ1 4590 7298
SYNJ2 -2936 2797
SYT5 3909 5940
TACO1 -4362 1969
TALDO1 -2422 2955
TBL1XR1 1832 1367
TBXAS1 -1594 8065
TECR -2066 7050
THEM4 -1077 8325
THTPA -3048 5912
TIAM2 4148 7191
TK1 481 -581
TK2 -2337 3463
TKT -3915 1831
TM7SF2 -2293 1418
TMEM126B 2827 440
TMEM186 -536 2723
TNFAIP8 -253 1289
TNFAIP8L1 -3523 588
TNFAIP8L2 -2420 5776
TPI1 -3845 6828
TPK1 2891 4576
TPMT 3015 -286
TPR 3482 5135
TPST1 507 6863
TPST2 -3145 3734
TRAP1 -1692 6777
TRIB3 1943 563
TRMT112 -4331 7797
TSPO -4236 8436
TST -4315 -727
TSTD1 -2107 8445
TXN -441 339
TXN2 -4048 5130
TXNRD1 -917 214
TYMP 3812 930
TYMS 2272 3871
UBA52 -4076 4404
UBB -3235 564
UBC -1858 2635
UBE2I -1908 3654
UBIAD1 -1734 7597
UCK1 -3644 8037
UCK2 -4247 1044
UCKL1 -587 7369
UCP2 -1653 6416
UGCG 3211 -30
UGDH 2943 4964
UGP2 2913 2171
UPP1 -1915 487
UQCR11 -4398 8422
UQCRB -2279 1779
UQCRC1 -3414 5054
UQCRC2 -547 6364
UQCRFS1 -1151 5771
UQCRH -4335 652
UQCRQ -3077 4201
UROD -4425 3279
UROS 2476 4994
UST -4351 6034
VAC14 -2575 2868
VAMP2 -146 536
VAPA 246 3839
VAPB 2579 8226
VDAC1 562 7841
VDR 1410 2694
VKORC1 -2536 6808
WASL 3043 7402
XYLB -180 2353
XYLT1 -3919 4457
XYLT2 -2551 2519
ZDHHC21 1344 2897



rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol
metric value
setSize 154
pMANOVA 7.22e-12
p.adjustMANOVA 3.01e-10
s.dist 0.332
s.RNA -0.326
s.meth -0.0598
p.RNA 3.23e-12
p.meth 0.203




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
SNU13 -3390 -644
RPS23 -4143 -355
NOP14 -1947 -739
RPS8 -3241 -349
RRP9 -3928 -254
EXOSC2 -2165 -380
RPL36 -4456 -158
NOB1 -2363 -264
FBL -4435 -91

Click HERE to show all gene set members

All member genes
RNA meth
BMS1 -579 282
BYSL -3043 5920
C1D 4426 3664
CSNK1D -3936 6586
CSNK1E -2264 7038
DCAF13 -932 1417
DDX21 3407 7489
DDX47 3238 899
DDX49 -4116 3923
DDX52 4766 3608
DHX37 -1637 6256
DIS3 4491 4903
EBNA1BP2 -256 1408
ERI1 4373 -203
EXOSC1 2117 7262
EXOSC10 2640 1784
EXOSC2 -2165 -380
EXOSC3 1800 4976
EXOSC4 -2984 5215
EXOSC5 -3455 472
EXOSC6 -1417 3480
EXOSC7 -4379 4110
EXOSC8 2904 5376
FAU -4443 5991
FBL -4435 -91
FCF1 2534 5745
FTSJ3 -1675 4982
GAR1 112 3773
GNL3 1788 1860
HEATR1 2241 6383
IMP3 -2364 6106
IMP4 -2654 4273
ISG20L2 2607 2767
KRR1 3279 -810
LTV1 2262 2910
MPHOSPH10 4624 5469
MPHOSPH6 560 6242
NCL -2029 6814
NHP2 -3603 6994
NIP7 1888 5750
NOB1 -2363 -264
NOC4L 108 5529
NOL11 3573 -392
NOL12 -1885 6019
NOL6 -1636 6101
NOL9 3666 -796
NOP10 -3556 2404
NOP14 -1947 -739
NOP2 -3190 5056
NOP56 118 117
NOP58 3438 2119
PDCD11 -1054 1980
PELP1 -560 6681
PES1 -4371 225
PNO1 3719 1463
PWP2 -3432 3413
RBM28 794 5611
RCL1 -451 7180
RIOK1 1003 7832
RIOK2 3845 1639
RIOK3 3912 2142
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPP14 3136 6104
RPP21 -3670 6725
RPP25 -1289 7163
RPP30 3233 4955
RPP38 2641 1315
RPP40 1403 2947
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
RRP1 855 4263
RRP7A -2117 3257
RRP9 -3928 -254
SENP3 -1401 8082
SNU13 -3390 -644
TBL3 -3035 5281
TEX10 4486 -299
THUMPD1 3128 1438
TRMT112 -4331 7797
TSR1 1770 6427
TSR3 -4459 1632
UBA52 -4076 4404
UTP15 4531 2200
UTP18 2019 4533
UTP20 3843 5003
UTP3 -1901 5911
UTP6 3583 1898
WDR12 2871 2290
WDR18 -1565 2126
WDR3 253 553
WDR36 2407 4917
WDR43 86 2132
WDR75 3145 3723
XRN2 -1953 2920



Developmental Biology

Developmental Biology
metric value
setSize 451
pMANOVA 1.06e-11
p.adjustMANOVA 4.26e-10
s.dist 0.197
s.RNA -0.196
s.meth -0.0181
p.RNA 2.02e-12
p.meth 0.516




Top 20 genes
Gene RNA meth
KRT10 -4382 -837
RPS2 -4547 -712
DOK2 -3914 -569
MAPK3 -4544 -479
LIMK1 -2745 -632
RPS23 -4143 -355
RPS8 -3241 -349
NR6A1 -3321 -323
CNTNAP1 -1712 -564
SEMA3A -1200 -798
SEMA4A -1006 -775
PSMD9 -4165 -186
RPL36 -4456 -158
PKP4 -1821 -304
MAP2K1 -3476 -148
GIT1 -3830 -130
RPS6KA4 -3821 -121
NCSTN -617 -457
POLR2A -851 -175
SRC -1513 -92

Click HERE to show all gene set members

All member genes
RNA meth
ABL1 -2249 5977
ABL2 495 4991
ABLIM1 -601 4445
ABLIM2 -923 7101
ACTB -2121 4265
ACTG1 -3714 6428
ACTR2 2174 4951
ACTR3 1312 4499
ACVR1B -2903 7504
ACVR2A -749 7271
ADAM10 419 3603
ADAM11 -986 49
ADAM22 1306 4152
AGAP2 -2373 1611
AGRN 3879 3516
AJUBA -71 -835
AKT1 -4078 4230
AKT2 -3887 3475
ALCAM -2962 465
ANK1 -564 253
ANK3 278 -855
AP2A1 -2951 1895
AP2M1 -4431 5734
AP2S1 -3760 3997
APH1A -4262 1663
APH1B 3033 2594
ARHGAP35 -3299 6432
ARHGAP39 772 8415
ARHGEF12 -1216 8154
ARHGEF7 -3086 964
ARPC1B -3966 2843
ARPC2 -83 5703
ARPC3 1376 4838
ARPC5 804 2343
ASH2L 1973 5772
BNIP2 3066 -571
CACNA1C -2576 3128
CACNA1I -3597 683
CACNB3 -1094 4217
CAP1 -1431 5579
CAPN1 -3796 5491
CAPNS1 -2076 6108
CASC3 -981 3341
CBFB 2561 1473
CCNC 3746 2192
CCND3 -3454 2914
CD72 -3731 1306
CDC42 2291 7063
CDK19 44 749
CDK2 360 6577
CDK4 -3226 6700
CDK5 -312 4651
CDK5R1 -3377 7721
CDK8 2703 2327
CDKN1A 205 7579
CDON 2717 -268
CEBPA -3050 8110
CEBPB -1226 2587
CEBPD -3979 1324
CEBPE -2132 1051
CFL1 -4050 4075
CHD9 1137 6134
CLASP1 -1376 3286
CLASP2 2090 2891
CLTA -2759 1476
CLTB -4330 600
CLTC -705 2682
CLTCL1 -2792 7791
CNOT6 3552 6051
CNTNAP1 -1712 -564
COL9A2 3094 1721
CREB1 2684 5066
CREBBP -2131 6830
CSNK2A2 1126 3957
CSNK2B -1331 7503
CTCF 1319 4700
CTNNB1 -867 6731
CUL2 3754 6010
CXCR4 -2975 6685
CYP51A1 3547 2962
DAG1 -1582 2764
DEK 3735 4890
DLG1 3992 5149
DLG4 -2940 284
DNM1 3668 2162
DNM2 -3963 6605
DOK2 -3914 -569
DOK4 -3794 6128
DPYSL2 399 7422
DRAP1 606 615
E2F1 2805 1130
EED 3870 2932
EFNA3 -821 7466
EFNA4 -232 7073
EFNB2 -2730 8212
EGR2 923 5319
EIF4A3 -3458 5329
EIF4G1 -3207 3220
EP300 1012 3364
EPAS1 2652 -699
EPHA4 -3418 6667
EPHB6 -4154 1026
ERBB2 -1613 7893
ETF1 1687 7120
EVL -15 3804
EZH2 4487 4485
EZR 1416 5759
FAM120B 4683 7550
FARP2 3207 1865
FAU -4443 5991
FES -4061 4123
FGF9 -2622 6748
FLI1 -2738 4363
FOXO1 -1206 821
FOXO3 -3182 7336
FOXP1 341 2546
FRS2 2876 165
FURIN -4531 8374
FYN -1981 2811
GAB2 -2379 350
GFI1 1219 2432
GIT1 -3830 -130
GRB10 -553 192
GRB2 -2429 5992
GRIN1 -2344 6304
GSK3B -648 3637
GSPT1 3481 4369
HDAC2 357 4593
HDAC3 -2463 8308
HHEX 3113 7494
HMGCR 615 4936
HOXA1 3512 221
HRAS -2578 1490
HSP90AA1 2910 4876
HSP90AB1 585 829
IL6R -1261 6551
IRS2 -4230 5305
ITGA1 1464 5574
ITGA2 4521 4016
ITGA5 -4058 6926
ITGAV 805 3287
ITSN1 3075 5424
JUN -2852 2775
KAT2A -124 2984
KAT2B 4300 630
KLF5 4338 7603
KMT2A 2145 -502
KMT2C 3111 8449
KMT2D 163 -326
KRAS 4256 4020
KRT10 -4382 -837
LAMA2 -594 5768
LDB1 -3362 4806
LIMK1 -2745 -632
LIMK2 -460 4617
LYPLA2 -4212 2325
MAML1 -1344 5639
MAML2 -3917 2218
MAML3 -2225 8147
MAP2K1 -3476 -148
MAP2K2 -4508 8056
MAP2K6 2656 2172
MAPK1 -664 2770
MAPK14 -471 2235
MAPK3 -4544 -479
MAPK7 -1945 3019
MAPK8 -584 6176
MBP -1991 4049
MED1 884 5989
MED10 -687 437
MED11 -994 2732
MED13 -548 6657
MED13L 1724 3819
MED15 -643 637
MED16 -3391 6781
MED17 2715 1178
MED18 987 -582
MED19 280 269
MED20 -1924 3815
MED21 3727 7649
MED22 -4101 6196
MED23 3644 2535
MED24 -2511 4354
MED25 -750 5856
MED26 -3998 4987
MED27 -707 2243
MED28 3571 6056
MED29 -2077 3182
MED30 -1894 1820
MED31 4533 8039
MED4 2210 1156
MED6 4248 7020
MED7 4219 451
MED8 1107 5186
MED9 -65 4035
MEF2A 2373 7468
MEF2D -2928 4570
MPZ -1876 5102
MYB 2627 533
MYH10 2967 3825
MYH9 -3031 3393
MYL12A -828 3613
MYL6 -4411 4209
MYO9B -1527 3151
NAB1 4175 1502
NAB2 890 3007
NCBP1 4364 6545
NCBP2 4238 3728
NCK1 1391 1103
NCK2 -4019 2464
NCOA2 2520 7322
NCOA3 3929 6898
NCOA6 1077 761
NCOR1 1467 1101
NCOR2 -3180 580
NCSTN -617 -457
NEO1 -2813 949
NOTCH1 -2630 2429
NR6A1 -3321 -323
NTN1 -3237 8233
NUMB 558 1647
ONECUT1 -791 6741
PABPC1 1108 3737
PAGR1 -4518 6339
PAK1 2857 4972
PAK2 1920 2509
PAK4 -2553 779
PAXIP1 2480 2299
PDLIM7 -1357 142
PFN1 -3627 2497
PFN2 -1285 8232
PIAS2 4247 6972
PIK3CA 2842 3290
PIK3CD -2911 153
PIK3R1 -2375 5157
PIK3R2 -1983 5365
PIK3R3 3664 3533
PIP5K1C -3773 8050
PITPNA 727 1699
PKNOX1 171 7175
PKP4 -1821 -304
PLCG1 345 5809
PLXNA2 -3298 4087
PLXNC1 545 1218
PLXND1 -3058 6377
PML 4203 1165
POLR2A -851 -175
POLR2B 647 1497
POLR2C -2229 4506
POLR2D 2056 1352
POLR2E -4392 2995
POLR2F -4196 6542
POLR2G -4186 8051
POLR2H -3384 7582
POLR2I -4069 6360
POLR2K 3044 2463
PPP3CB 2850 5276
PRKACA -2849 3985
PRKACB 1232 7740
PRKAR2A -142 532
PRKCA -2013 8000
PRKCQ -36 3938
PRNP -880 861
PSEN1 1406 1724
PSEN2 -29 4736
PSENEN -1546 5332
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PTK2 -271 2498
PTPN11 404 3777
PTPRA -3076 5280
PTPRC 3435 1766
RAC1 1432 7511
RANBP9 541 4150
RARA -2244 2140
RARG 497 3360
RASA1 4274 3050
RBBP4 1636 2574
RBBP5 3016 5848
RBPJ 1401 3986
RBX1 776 6226
RELA -3471 5749
RHOA -152 1886
RHOB 1489 4751
RND1 3209 344
RNPS1 -1587 2194
ROCK1 3813 2216
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS6KA1 -2403 6292
RPS6KA2 -1652 6457
RPS6KA4 -3821 -121
RPS6KA5 4565 7378
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
RRAS 2000 4131
RUNX1 4146 3270
SDCBP 183 7446
SEMA3A -1200 -798
SEMA4A -1006 -775
SEMA4D -659 721
SEMA7A 32 4968
SHC1 1742 7320
SIAH1 1400 5770
SIAH2 2663 1878
SLIT1 -1619 4573
SMAD2 2851 1116
SMAD3 13 5325
SMAD4 3942 777
SMARCA4 -3042 2893
SNW1 3124 3991
SOS1 4314 3280
SOS2 1177 87
SPAG9 362 1963
SPI1 -1412 3235
SPTAN1 -2478 372
SPTBN1 -2562 7757
SPTBN5 802 2482
SRC -1513 -92
SREBF1 -2440 5382
SREBF2 325 3407
SRGAP1 3705 7388
SRGAP3 4164 2145
ST8SIA4 3378 3040
STAT3 1093 7085
STX1A -2317 1045
STX1B 3311 865
TBL1XR1 1832 1367
TCF12 906 -80
TCF3 -605 3020
TFDP1 1708 471
TFDP2 -2800 3770
TGFB1 -3735 4353
TLN1 -3378 2103
TNF 4497 -678
TRIO -2671 8416
TRPC1 2903 4764
TSC22D1 2635 7169
TYROBP -3335 835
UBA52 -4076 4404
UBB -3235 564
UBC -1858 2635
UPF2 4081 4021
UPF3A -542 6410
USP33 4371 -215
UTRN 1865 460
VASP -2524 3426
VAV2 780 7727
VAV3 -3913 8297
WASL 3043 7402
WDR5 -2102 4719
WNT1 -251 7669
YES1 1814 -624
YY1 -3924 2757
ZNF335 -97 2918
ZNF638 4449 5958
ZSWIM8 -2844 4681



rRNA processing

rRNA processing
metric value
setSize 159
pMANOVA 1.56e-11
p.adjustMANOVA 6.08e-10
s.dist 0.322
s.RNA -0.316
s.meth -0.0615
p.RNA 7.74e-12
p.meth 0.183




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
SNU13 -3390 -644
RPS23 -4143 -355
NOP14 -1947 -739
RPS8 -3241 -349
RRP9 -3928 -254
EXOSC2 -2165 -380
RPL36 -4456 -158
NOB1 -2363 -264
FBL -4435 -91

Click HERE to show all gene set members

All member genes
RNA meth
BMS1 -579 282
BYSL -3043 5920
C1D 4426 3664
CSNK1D -3936 6586
CSNK1E -2264 7038
DCAF13 -932 1417
DDX21 3407 7489
DDX47 3238 899
DDX49 -4116 3923
DDX52 4766 3608
DHX37 -1637 6256
DIS3 4491 4903
EBNA1BP2 -256 1408
ELAC2 -2268 5479
ERI1 4373 -203
EXOSC1 2117 7262
EXOSC10 2640 1784
EXOSC2 -2165 -380
EXOSC3 1800 4976
EXOSC4 -2984 5215
EXOSC5 -3455 472
EXOSC6 -1417 3480
EXOSC7 -4379 4110
EXOSC8 2904 5376
FAU -4443 5991
FBL -4435 -91
FCF1 2534 5745
FTSJ3 -1675 4982
GAR1 112 3773
GNL3 1788 1860
HEATR1 2241 6383
IMP3 -2364 6106
IMP4 -2654 4273
ISG20L2 2607 2767
KRR1 3279 -810
LTV1 2262 2910
MPHOSPH10 4624 5469
MPHOSPH6 560 6242
MRM1 -1055 2116
MTERF4 -1815 5833
NCL -2029 6814
NHP2 -3603 6994
NIP7 1888 5750
NOB1 -2363 -264
NOC4L 108 5529
NOL11 3573 -392
NOL12 -1885 6019
NOL6 -1636 6101
NOL9 3666 -796
NOP10 -3556 2404
NOP14 -1947 -739
NOP2 -3190 5056
NOP56 118 117
NOP58 3438 2119
NSUN4 3237 782
PDCD11 -1054 1980
PELP1 -560 6681
PES1 -4371 225
PNO1 3719 1463
PWP2 -3432 3413
RBM28 794 5611
RCL1 -451 7180
RIOK1 1003 7832
RIOK2 3845 1639
RIOK3 3912 2142
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPP14 3136 6104
RPP21 -3670 6725
RPP25 -1289 7163
RPP30 3233 4955
RPP38 2641 1315
RPP40 1403 2947
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
RRP1 855 4263
RRP7A -2117 3257
RRP9 -3928 -254
SENP3 -1401 8082
SNU13 -3390 -644
TBL3 -3035 5281
TEX10 4486 -299
TFB1M 2964 2155
THUMPD1 3128 1438
TRMT112 -4331 7797
TSR1 1770 6427
TSR3 -4459 1632
UBA52 -4076 4404
UTP15 4531 2200
UTP18 2019 4533
UTP20 3843 5003
UTP3 -1901 5911
UTP6 3583 1898
WDR12 2871 2290
WDR18 -1565 2126
WDR3 253 553
WDR36 2407 4917
WDR43 86 2132
WDR75 3145 3723
XRN2 -1953 2920



Influenza Infection

Influenza Infection
metric value
setSize 128
pMANOVA 2.69e-11
p.adjustMANOVA 1.01e-09
s.dist 0.356
s.RNA -0.355
s.meth -0.0289
p.RNA 4.75e-12
p.meth 0.574




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
RPS23 -4143 -355
RPS8 -3241 -349
RPL36 -4456 -158
POLR2A -851 -175

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
CALR 1298 3555
CANX 130 7355
CLTA -2759 1476
CLTC -705 2682
CPSF4 -3019 7194
DNAJC3 1878 8319
EIF2AK2 4762 189
FAU -4443 5991
GRSF1 662 1474
GTF2F1 -3630 1349
GTF2F2 199 4275
HSP90AA1 2910 4876
HSPA1A -3404 1113
IPO5 -719 8363
ISG15 4605 -542
KPNA1 2524 6172
KPNA2 2087 843
KPNA3 3432 1404
KPNA4 3745 8152
KPNA5 4407 1689
KPNB1 3755 5921
NDC1 1276 -274
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
PABPN1 -3354 7278
PARP1 -684 377
POLR2A -851 -175
POLR2B 647 1497
POLR2C -2229 4506
POLR2D 2056 1352
POLR2E -4392 2995
POLR2F -4196 6542
POLR2G -4186 8051
POLR2H -3384 7582
POLR2I -4069 6360
POLR2K 3044 2463
POM121 -1366 5167
POM121C -3196 5663
RAE1 1852 710
RAN 136 2287
RANBP2 3105 4436
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
SEC13 -2693 7357
SEH1L 3110 6644
TGFB1 -3735 4353
TPR 3482 5135
UBA52 -4076 4404
XPO1 4524 5628



Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives
metric value
setSize 219
pMANOVA 3.52e-11
p.adjustMANOVA 1.28e-09
s.dist 0.271
s.RNA -0.268
s.meth -0.0416
p.RNA 1.13e-11
p.meth 0.292




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
TST -4315 -727
PAOX -1921 -784
RPS23 -4143 -355
RPS8 -3241 -349
IL4I1 -2435 -346
PSMD9 -4165 -186
RPL36 -4456 -158
SLC7A5 -709 -652
BCKDK -3363 -102

Click HERE to show all gene set members

All member genes
RNA meth
AANAT 1657 7396
ACADSB 2458 8307
ACAT1 1601 5751
ADO 536 6026
AFMID 3535 1182
AGMAT 3091 113
AHCY -4145 1896
AIMP2 -491 6011
ALDH18A1 -1157 6062
ALDH4A1 -3988 3158
ALDH6A1 470 335
ALDH9A1 -399 6692
AMD1 3688 1679
AMDHD1 -1093 7850
ARG2 383 5936
ASL -2180 7724
ASNS 2780 2242
ASRGL1 -1827 4268
AUH 231 1233
AZIN1 295 202
AZIN2 -1187 711
BCAT1 226 3114
BCAT2 -1179 2278
BCKDHA -4290 3276
BCKDHB 4606 1441
BCKDK -3363 -102
CARNMT1 2688 1640
CARNS1 -431 4453
CKB -1975 6935
CPS1 2485 -256
CRYM -545 4980
CSAD 1308 3086
CTH 3759 1184
DBT 4728 1175
DHTKD1 4572 4620
DLAT 944 1054
DLD 1996 4527
DLST -3161 7228
ECHS1 -1979 4579
EEF1E1 1868 3266
EEFSEC -1190 6233
ENOPH1 -3474 4057
ETHE1 -4488 804
FAH -4018 526
FAU -4443 5991
GCDH -4546 937
GCSH 2230 8071
GLS 4154 572
GLUD1 -1031 5206
GLUL -1223 7319
GOT1 2542 4943
GOT2 463 1040
GPT2 4321 6335
GRHPR -1126 1385
GSR -3081 1990
GSTZ1 849 2248
HIBADH 2440 -309
HIBCH 4500 7161
HPD 4337 4383
IL4I1 -2435 -346
IVD 1193 963
KMO 3239 2433
LIAS 4299 6063
LIPT1 4262 7533
LIPT2 -1469 5908
MCCC1 -396 8183
MCCC2 4610 5255
MPST -4491 6640
MTAP 3017 8057
MTR 2390 3011
MTRR 3249 5670
NAGS -4054 5040
NDUFAB1 -2579 1043
NMRAL1 -2997 6966
NQO1 -2832 4198
OAT 1924 329
OAZ1 -4127 6795
OAZ2 -1995 7617
OAZ3 1225 3936
ODC1 -511 6387
OGDH -1954 1499
PAOX -1921 -784
PAPSS1 446 6222
PCBD1 -2499 8417
PDHB 1229 6538
PDHX 1149 5278
PHGDH 4113 6806
PHYKPL 909 -693
PPM1K 4695 3255
PSAT1 4288 3577
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PSPH 3508 5960
PSTK 1474 7792
PXMP2 1026 1966
PYCR2 -4468 1819
QDPR 3868 154
RIMKLB -1087 7026
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
SARDH -3440 8313
SCLY -529 681
SEPHS2 -2130 4134
SERINC1 1510 307
SERINC3 134 2970
SERINC4 2333 -52
SERINC5 -2682 3136
SHMT1 105 4297
SLC25A12 1076 2412
SLC25A13 305 7294
SLC25A15 -1933 1269
SLC25A44 21 5950
SLC36A4 1284 1392
SLC3A2 -3776 497
SLC44A1 -164 3793
SLC5A5 -131 1265
SLC7A5 -709 -652
SRM -2716 3333
TST -4315 -727
TSTD1 -2107 8445
TXN2 -4048 5130
TXNRD1 -917 214
UBA52 -4076 4404



Infectious disease

Infectious disease
metric value
setSize 530
pMANOVA 5.03e-11
p.adjustMANOVA 1.78e-09
s.dist 0.177
s.RNA -0.177
s.meth 0.002
p.RNA 5.98e-12
p.meth 0.938




Top 20 genes
Gene RNA meth
FURIN -4531 8374
BRK1 -4516 8055
MAP2K2 -4508 8056
ARF1 -4250 8404
ADCY9 -4217 8419
RPS12 -4451 7699
RPL8 -4481 7647
POLR2G -4186 8051
HBEGF -4045 8169
VAV3 -3913 8297
RPL18 -4194 7741
MVB12A -4099 7863
RPL36AL -4421 7261
NCKIPSD -3825 8021
RCC1 -4524 6687
DVL3 -3607 8314
PSMD2 -4346 6742
VCP -3583 7877
CDK9 -4219 6663
SNF8 -3710 7542

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
ABI1 3918 523
ABI2 2261 1460
ABL1 -2249 5977
ACTB -2121 4265
ACTG1 -3714 6428
ACTR2 2174 4951
ACTR3 1312 4499
ADAM17 2413 4714
ADCY4 757 6234
ADCY7 -1798 2400
ADCY9 -4217 8419
ADM -2837 7632
ADORA2A -1548 8364
ADRB2 -1002 5274
AHCYL1 331 6911
ANTXR2 -3667 -806
AP1B1 -3618 7607
AP1G1 1472 6363
AP1M1 -4274 2151
AP1S3 2348 5075
AP2A1 -2951 1895
AP2M1 -4431 5734
AP2S1 -3760 3997
ARF1 -4250 8404
ARID4A 4099 5298
ARID4B 3983 877
ARPC1B -3966 2843
ARPC2 -83 5703
ARPC3 1376 4838
ARPC5 804 2343
ATP1A1 -1037 5489
ATP1A3 865 5196
ATP1B1 378 8146
ATP1B3 2449 -277
ATP6V1H -1097 5715
B2M 2830 3658
BAIAP2 -2723 6308
BANF1 -4022 4199
BECN1 5 7998
BRD4 2237 -833
BRK1 -4516 8055
BRMS1 -4306 5625
BTRC -2202 66
C3AR1 4556 1729
CALM1 1471 3996
CALR 1298 3555
CANX 130 7355
CASP1 3166 -381
CBL -730 7616
CBX1 -656 4266
CCNH 4325 5990
CCNK 3396 2118
CCNT1 962 211
CD247 -3063 3173
CD4 -3009 6004
CDC42 2291 7063
CDK7 3900 3672
CDK9 -4219 6663
CEBPD -3979 1324
CHD3 -3131 1467
CHD4 -1096 1893
CHMP1A -3080 982
CHMP2A -3792 7013
CHMP2B 2766 5744
CHMP3 314 -59
CHMP4A 1988 1773
CHMP4B -4368 4124
CHMP5 4584 1922
CHMP6 -4415 1561
CHMP7 -84 6937
CLTA -2759 1476
CLTC -705 2682
COMT -4115 -295
CORO1A -4177 3099
CPSF4 -3019 7194
CRBN 3913 5723
CREB1 2684 5066
CRK 2137 5956
CTDP1 -4073 1498
CTNNB1 -867 6731
CTNND1 4276 2992
CTSL 3221 8394
CUL5 4403 5417
CXCR4 -2975 6685
CYBA -3513 5379
CYFIP1 -2919 8327
CYFIP2 765 4244
DAD1 -725 -641
DAXX 1297 3531
DBP -2519 6319
DDX5 -1978 1749
DNAJC3 1878 8319
DPEP2 -14 5071
DUSP16 -2161 -243
DUT -3423 4927
DVL1 -4517 5359
DVL2 -2904 646
DVL3 -3607 8314
DYNC1H1 -621 1172
DYNC1I2 -163 261
DYNC1LI1 2931 6081
DYNC1LI2 961 3137
DYNLL1 -1533 5391
DYNLL2 -2741 3308
EDEM2 -1755 1857
EED 3870 2932
EEF2 -4461 1316
EIF2AK2 4762 189
ELL -2931 2306
ELMO1 -2858 4458
ELMO2 965 3635
ENO1 -3898 3952
ENTPD1 256 7155
ENTPD5 4492 3843
EPS15 4410 4996
ERCC2 -1586 1785
ERCC3 1777 3558
EZH2 4487 4485
FAU -4443 5991
FEN1 -1067 5510
FGR -2747 6452
FKBP1A -714 6135
FKBP4 -1987 4677
FURIN -4531 8374
FUT8 3256 7583
FXYD7 -2733 -773
FYN -1981 2811
FZD7 2032 2395
GANAB -4170 2335
GATAD2A -1612 7033
GATAD2B 2313 7362
GGT1 -3229 -730
GIPR -274 462
GNAI2 -3426 5421
GNAI3 1484 705
GNAS -2079 -276
GNB1 -2758 -391
GNB2 -2980 6049
GNB4 3395 8172
GNB5 373 5796
GNG2 92 4290
GNG3 4104 8393
GNG4 3296 7006
GNG5 -204 3751
GNG7 619 -475
GNGT2 -1460 -71
GPS2 -1042 1242
GRB2 -2429 5992
GRSF1 662 1474
GSDMD -2430 4189
GSK3A -3011 4821
GSK3B -648 3637
GTF2A1 2271 3947
GTF2A2 1864 4288
GTF2B 4279 1777
GTF2E2 2178 2527
GTF2F1 -3630 1349
GTF2F2 199 4275
GTF2H3 327 8269
GTF2H4 -2613 6171
GTF2H5 2768 1888
HBEGF -4045 8169
HDAC1 -483 4910
HDAC2 357 4593
HDAC3 -2463 8308
HGS -218 2237
HLA-A -4258 2274
HMG20B -3402 5116
HMGA1 -3906 5560
HNRNPK -1202 5618
HRH2 221 7921
HSP90AA1 2910 4876
HSP90AB1 585 829
HSPA1A -3404 1113
IFNAR1 2643 6059
IFNAR2 -1233 1950
IFNGR1 -132 4337
IFNGR2 1058 6521
IL6R -1261 6551
IMPDH1 -2518 6
IMPDH2 -4240 5354
IPO5 -719 8363
IRS1 -2324 4427
ISG15 4605 -542
ITGA4 2309 4664
ITPR1 918 6634
ITPR2 2226 4474
ITPR3 643 2887
JAK1 -2780 6986
JAK2 4742 6248
JUN -2852 2775
KDM1A -1741 4065
KPNA1 2524 6172
KPNA2 2087 843
KPNA3 3432 1404
KPNA4 3745 8152
KPNA5 4407 1689
KPNB1 3755 5921
LCK -1530 2504
LIG1 -689 1862
LIG4 4297 6928
MAN1B1 -3220 1152
MAN2A1 2786 3683
MAP2K1 -3476 -148
MAP2K2 -4508 8056
MAP2K3 -3178 38
MAP2K4 569 3168
MAP2K6 2656 2172
MAP2K7 -3762 2099
MAPK1 -664 2770
MAPK14 -471 2235
MAPK3 -4544 -479
MAPK8 -584 6176
MBD3 -3800 7276
MGAT1 -4026 3340
MGAT2 -1681 5371
MGAT4A -1115 3003
MGAT4B -3344 2849
MGAT5 -3674 6294
MNAT1 1367 2609
MOGS -3527 4407
MTA2 -1649 2515
MTA3 -873 857
MVB12A -4099 7863
MYH9 -3031 3393
MYO9B -1527 3151
NCBP1 4364 6545
NCBP2 4238 3728
NCK1 1391 1103
NCKAP1L 731 1935
NCKIPSD -3825 8021
NCOR1 1467 1101
NCOR2 -3180 580
NDC1 1276 -274
NEDD4L -1595 223
NELFA -706 6889
NELFB -4311 5472
NELFCD -176 4159
NELFE -2330 8447
NFKB2 -1387 2526
NLRP3 -1832 6403
NMT1 3786 5677
NMT2 3541 2421
NOXA1 -1390 6268
NR3C1 795 4250
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
P2RX4 -2366 621
PABPN1 -3354 7278
PACS1 -1903 5954
PAK2 1920 2509
PARP1 -684 377
PARP10 4138 249
PARP14 4751 288
PARP16 -2060 3444
PARP4 3939 2826
PARP6 -577 7359
PARP8 1448 -314
PARP9 4759 3387
PDCD6IP 3551 3740
PHF21A -2599 3544
PIK3R4 2129 2082
PLCG1 345 5809
PLCG2 239 6178
PLK2 -1310 8395
PML 4203 1165
POLR2A -851 -175
POLR2B 647 1497
POLR2C -2229 4506
POLR2D 2056 1352
POLR2E -4392 2995
POLR2F -4196 6542
POLR2G -4186 8051
POLR2H -3384 7582
POLR2I -4069 6360
POLR2K 3044 2463
POM121 -1366 5167
POM121C -3196 5663
PPIA -2974 5622
PRKACA -2849 3985
PRKACB 1232 7740
PRKAR1A 538 3914
PRKAR1B -2289 -687
PRKAR2A -142 532
PRKCSH -4375 5320
PSIP1 3853 2179
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PSTPIP1 -3996 2324
PTGER2 -2655 7393
PTGER4 486 3095
PTGES3 3489 2735
PTK2 -271 2498
PYCARD -2341 3155
RAB5A 3764 1760
RAB7A -2395 -526
RAC1 1432 7511
RAE1 1852 710
RAN 136 2287
RANBP1 -977 1651
RANBP2 3105 4436
RANGAP1 -1846 6695
RB1 1147 1518
RBBP4 1636 2574
RBX1 776 6226
RCC1 -4524 6687
RCOR1 -1197 4222
RELA -3471 5749
REST 2492 2105
RHBDF2 -1568 4216
RNF213 4054 3702
RNGTT 3198 1738
RNMT 3661 2751
ROCK1 3813 2216
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPN1 -3275 6578
RPN2 -618 3798
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
S1PR1 784 -333
SAP18 -1992 6235
SAP30 -1829 5426
SAP30L -3018 5401
SEC13 -2693 7357
SEH1L 3110 6644
SFPQ 1843 6453
SH3GL1 -3989 6433
SIGMAR1 -863 5834
SKP1 2353 3193
SLC25A4 2217 7484
SNF8 -3710 7542
SRC -1513 -92
SSRP1 -2405 2951
ST3GAL1 -2314 5875
ST3GAL2 -2611 2056
ST3GAL3 -1465 3508
ST3GAL4 -3567 2599
ST6GAL1 1268 3705
ST6GALNAC3 -2985 7567
ST6GALNAC4 -387 1062
STAM 1591 1978
STAM2 4383 4717
STAT2 4692 3486
STT3A 533 1991
STX1A -2317 1045
STX1B 3311 865
SUDS3 2505 3071
SUGT1 3040 6398
SUMO1 2148 4431
SUPT16H 777 2239
SUPT4H1 -1880 7521
SUPT5H -2338 5377
SYK -2039 3901
TAF10 -2924 2748
TAF11 4222 -261
TAF12 1194 486
TAF13 3766 3314
TAF15 -3822 7204
TAF2 4458 1412
TAF3 3463 7268
TAF4 -51 5640
TAF4B 866 716
TAF5 2433 3006
TAF6 -1891 4411
TAF7 745 6649
TAF9 3601 759
TBK1 4506 6515
TBL1XR1 1832 1367
TCEA1 2925 2742
TGFB1 -3735 4353
TLR2 1473 6797
TLR9 -3429 -408
TPR 3482 5135
TRIM27 2299 5362
TRIM28 -4090 3417
TSG101 1806 1787
TUBB -254 3715
TXN -441 339
TXNIP 508 3975
TXNRD1 -917 214
TYK2 -1723 1909
UBA52 -4076 4404
UBAP1 -2537 958
UBB -3235 564
UBC -1858 2635
UBE2I -1908 3654
UVRAG 4460 1515
VAMP1 201 4166
VAMP2 -146 536
VAV1 -3536 6946
VAV2 780 7727
VAV3 -3913 8297
VCP -3583 7877
VEGFA -3785 832
VHL -1931 2728
VIPR1 -2453 1741
VPS25 -3249 1068
VPS28 -4254 6113
VPS33B -2408 1344
VPS36 4448 285
VPS37A 3854 7391
VPS37B -3422 2190
VPS37C -416 4251
VPS4A -4114 1747
VTA1 3696 6287
WASF1 -2311 763
WASF2 -1673 1239
WASL 3043 7402
WIPF1 -1158 2905
WIPF2 1628 568
XPO1 4524 5628
XRCC4 1549 6580
XRCC5 475 3525
XRCC6 -2419 2815
YES1 1814 -624
ZBP1 4600 518
ZCRB1 3807 2608



Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol
metric value
setSize 147
pMANOVA 6.92e-11
p.adjustMANOVA 2.37e-09
s.dist 0.324
s.RNA -0.317
s.meth -0.0664
p.RNA 3.79e-11
p.meth 0.167




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
SNU13 -3390 -644
RPS23 -4143 -355
NOP14 -1947 -739
RPS8 -3241 -349
RRP9 -3928 -254
EXOSC2 -2165 -380
RPL36 -4456 -158
NOB1 -2363 -264
FBL -4435 -91

Click HERE to show all gene set members

All member genes
RNA meth
BMS1 -579 282
BYSL -3043 5920
C1D 4426 3664
CSNK1D -3936 6586
CSNK1E -2264 7038
DCAF13 -932 1417
DDX21 3407 7489
DDX47 3238 899
DDX49 -4116 3923
DDX52 4766 3608
DHX37 -1637 6256
DIS3 4491 4903
EBNA1BP2 -256 1408
ERI1 4373 -203
EXOSC1 2117 7262
EXOSC10 2640 1784
EXOSC2 -2165 -380
EXOSC3 1800 4976
EXOSC4 -2984 5215
EXOSC5 -3455 472
EXOSC6 -1417 3480
EXOSC7 -4379 4110
EXOSC8 2904 5376
FAU -4443 5991
FBL -4435 -91
FCF1 2534 5745
FTSJ3 -1675 4982
GNL3 1788 1860
HEATR1 2241 6383
IMP3 -2364 6106
IMP4 -2654 4273
ISG20L2 2607 2767
KRR1 3279 -810
LTV1 2262 2910
MPHOSPH10 4624 5469
MPHOSPH6 560 6242
NCL -2029 6814
NIP7 1888 5750
NOB1 -2363 -264
NOC4L 108 5529
NOL11 3573 -392
NOL12 -1885 6019
NOL6 -1636 6101
NOL9 3666 -796
NOP14 -1947 -739
NOP56 118 117
NOP58 3438 2119
PDCD11 -1054 1980
PELP1 -560 6681
PES1 -4371 225
PNO1 3719 1463
PWP2 -3432 3413
RBM28 794 5611
RCL1 -451 7180
RIOK1 1003 7832
RIOK2 3845 1639
RIOK3 3912 2142
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPP14 3136 6104
RPP21 -3670 6725
RPP25 -1289 7163
RPP30 3233 4955
RPP38 2641 1315
RPP40 1403 2947
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
RRP1 855 4263
RRP7A -2117 3257
RRP9 -3928 -254
SENP3 -1401 8082
SNU13 -3390 -644
TBL3 -3035 5281
TEX10 4486 -299
TSR1 1770 6427
UBA52 -4076 4404
UTP15 4531 2200
UTP18 2019 4533
UTP20 3843 5003
UTP3 -1901 5911
UTP6 3583 1898
WDR12 2871 2290
WDR18 -1565 2126
WDR3 253 553
WDR36 2407 4917
WDR43 86 2132
WDR75 3145 3723
XRN2 -1953 2920



Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
metric value
setSize 40
pMANOVA 1.69e-10
p.adjustMANOVA 5.64e-09
s.dist 0.606
s.RNA -0.596
s.meth -0.109
p.RNA 6.78e-11
p.meth 0.233




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
EIF3B -3751 -643
RPS23 -4143 -355
RPS8 -3241 -349

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 2834 6703
EIF2S2 2873 5131
EIF3A -322 188
EIF3B -3751 -643
EIF3E 603 4012
EIF3F -4422 1788
EIF3G -4464 1822
EIF3H -2933 5015
EIF3I -4163 2663
EIF3J 3604 3059
EIF3K -3579 8409
EIF3L -4426 6698
EIF3M 1553 7241
FAU -4443 5991
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692



Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
metric value
setSize 48
pMANOVA 3.88e-10
p.adjustMANOVA 1.26e-08
s.dist 0.545
s.RNA -0.539
s.meth -0.0751
p.RNA 1.03e-10
p.meth 0.369




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
EIF3B -3751 -643
RPS23 -4143 -355
RPS8 -3241 -349

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 2834 6703
EIF2S2 2873 5131
EIF3A -322 188
EIF3B -3751 -643
EIF3E 603 4012
EIF3F -4422 1788
EIF3G -4464 1822
EIF3H -2933 5015
EIF3I -4163 2663
EIF3J 3604 3059
EIF3K -3579 8409
EIF3L -4426 6698
EIF3M 1553 7241
EIF4A1 -2281 5352
EIF4A2 3092 5327
EIF4B -3478 3082
EIF4E 3927 5614
EIF4EBP1 -3124 3840
EIF4G1 -3207 3220
EIF4H -4497 3675
FAU -4443 5991
PABPC1 1108 3737
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692



Innate Immune System

Innate Immune System
metric value
setSize 616
pMANOVA 5.23e-10
p.adjustMANOVA 1.65e-08
s.dist 0.157
s.RNA -0.156
s.meth -0.00648
p.RNA 7.63e-11
p.meth 0.788




Top 20 genes
Gene RNA meth
LAMTOR1 -4490 -649
CARD9 -2793 -783
MAPK3 -4544 -479
LIMK1 -2745 -632
AGA -4257 -404
PTGES2 -3345 -437
NLRX1 -3923 -361
AGPAT2 -4267 -330
TLR9 -3429 -408
RAB7A -2395 -526
LAMTOR2 -4374 -288
LPCAT1 -2221 -422
PSMD9 -4165 -186
PYGB -3255 -230
ATP8B4 -1498 -471
GZMM -3188 -220
TLR6 -989 -596
MAP2K1 -3476 -148
KCMF1 -973 -492
NCF4 -3240 -141

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -4540 7306
AAMP -4438 1170
ABI1 3918 523
ABI2 2261 1460
ABL1 -2249 5977
ACAA1 -2770 6285
ACLY -188 2355
ACTB -2121 4265
ACTG1 -3714 6428
ACTR10 1835 5133
ACTR1B -3707 3813
ACTR2 2174 4951
ACTR3 1312 4499
ADAM10 419 3603
ADAM8 -2930 7481
ADGRE5 -2016 2059
AGA -4257 -404
AGL 3703 2766
AGPAT2 -4267 -330
AHCYL1 331 6911
AIM2 4334 -563
ALAD -3206 374
ALDOA -3406 648
ALDOC 482 7310
ALOX5 -1706 6147
AMPD3 -2600 4571
ANO6 -1694 7673
AP1M1 -4274 2151
APAF1 652 7539
APEH -3495 432
APP -2922 7596
APRT -4487 7685
ARHGAP9 -3479 392
ARL8A -4365 136
ARMC8 1845 4280
ARPC1B -3966 2843
ARPC2 -83 5703
ARPC3 1376 4838
ARPC5 804 2343
ARSA 1157 -585
ARSB 809 6874
ASAH1 1480 3500
ATAD3B -1912 5589
ATF1 3822 690
ATG12 3590 4638
ATG5 4073 1142
ATG7 -2328 1263
ATOX1 -2888 8027
ATP11A -1098 5484
ATP11B 1720 -214
ATP6V0A1 -1930 5542
ATP6V0A2 4177 5249
ATP6V0B -3862 4939
ATP6V0C -2681 2508
ATP6V0D1 -2963 5821
ATP6V0E1 -3186 5554
ATP6V0E2 45 -8
ATP6V1A 286 3932
ATP6V1B2 -937 2977
ATP6V1C1 786 3448
ATP6V1D 1060 449
ATP6V1E1 661 6230
ATP6V1F -4357 2967
ATP6V1G2 1311 7771
ATP6V1H -1097 5715
ATP8A1 591 -197
ATP8B4 -1498 -471
B2M 2830 3658
B4GALT1 -2892 7957
BAIAP2 -2723 6308
BCL10 3317 6266
BCL2 3373 55
BCL2L1 37 5923
BIN2 -3333 3315
BIRC2 4112 4512
BIRC3 3414 593
BRI3 -2882 3769
BRK1 -4516 8055
BST2 2756 -711
BTRC -2202 66
C3AR1 4556 1729
C6orf120 -657 7911
C8G -2059 4683
CAB39 -619 -207
CALM1 1471 3996
CAND1 2776 1732
CAP1 -1431 5579
CAPN1 -3796 5491
CAPZA1 2568 7829
CAPZA2 2014 3750
CARD11 -1485 5811
CARD9 -2793 -783
CASP1 3166 -381
CASP10 3024 1617
CASP4 1969 510
CASP8 637 5804
CASP9 165 703
CAT -305 -221
CCT2 1073 3456
CCT8 -833 2010
CD247 -3063 3173
CD300A 3363 -870
CD4 -3009 6004
CD44 -2857 4410
CD46 4596 5388
CD47 3677 2452
CD53 -840 -466
CD55 -810 3298
CD58 2863 5830
CD59 -2407 4486
CD63 -4429 7202
CD81 -2909 2422
CDC34 -3730 6244
CDC42 2291 7063
CDK13 146 5488
CEACAM1 1921 827
CEP290 4649 7343
CFL1 -4050 4075
CHUK 1417 2714
CKAP4 -2260 8317
CMTM6 2761 4088
CNN2 -556 2041
CNPY3 -3805 3201
COMMD3 1824 611
COMMD9 -558 85
COPB1 2725 2901
COTL1 -812 2431
CPNE1 -3328 4825
CPNE3 291 2510
CPPED1 -295 5767
CRCP 1721 6175
CREB1 2684 5066
CREBBP -2131 6830
CREG1 -3823 1570
CRK 2137 5956
CSNK2B -1331 7503
CSTB -1654 6923
CTNNB1 -867 6731
CTSA -3502 2093
CTSB -2639 7080
CTSC 738 2318
CTSD -4228 8435
CTSL 3221 8394
CTSS 1234 -510
CTSV -1526 7165
CTSZ -3678 -74
CUL1 4686 1579
CYB5R3 -3770 4999
CYBA -3513 5379
CYFIP1 -2919 8327
CYFIP2 765 4244
CYLD 2719 5370
CYSTM1 -2383 7328
DBNL -3926 2976
DDX41 -4044 5735
DDX58 4744 2919
DEGS1 -1251 4801
DERA 2361 7436
DGAT1 -3596 6449
DHX36 4244 1796
DHX58 4679 1451
DHX9 -722 6426
DIAPH1 -990 5138
DNAJC13 3301 210
DNAJC3 1878 8319
DNAJC5 -3733 3123
DNM1 3668 2162
DNM2 -3963 6605
DPP7 -4248 7270
DSN1 4114 2710
DTX4 -2648 5392
DUSP3 -3326 6583
DUSP4 -1275 3594
DUSP6 300 7754
DUSP7 -2891 6463
DYNC1H1 -621 1172
DYNC1LI1 2931 6081
DYNLL1 -1533 5391
DYNLT1 2338 4678
ECSIT -3238 6323
EEA1 3263 1447
EEF1A1 -4059 2014
EEF2 -4461 1316
ELMO1 -2858 4458
ELMO2 965 3635
ENPP4 998 1345
EP300 1012 3364
ERP44 2658 127
FABP5 761 3670
FADD -1355 2280
FAF2 -679 7657
FBXW11 -2068 8437
FGR -2747 6452
FOS -3745 4083
FTH1 -2381 3732
FTL -2022 3971
FUCA1 -3588 2333
FUCA2 260 619
FYN -1981 2811
GAA -3165 1089
GAB2 -2379 350
GALNS -1700 6572
GCA 1117 2709
GDI2 1939 7902
GGH 1578 6724
GHDC -3293 2859
GLB1 -1934 7211
GLIPR1 997 393
GM2A -23 6425
GMFG -2851 6341
GNS -638 5474
GOLGA7 880 3423
GPI -3307 6596
GRAP2 -3151 6250
GRB2 -2429 5992
GRN -2095 3090
GSDMD -2430 4189
GSTP1 -3395 6832
GUSB -2990 4887
GYG1 -3201 6468
GZMM -3188 -220
HEBP2 -2292 5581
HERC5 4748 1229
HEXB -1501 7586
HGSNAT -323 355
HLA-A -4258 2274
HLA-B -1024 513
HLA-C -217 6790
HLA-E -1278 3744
HLA-H -4103 7849
HMGB1 981 2532
HMOX2 -3873 704
HRAS -2578 1490
HSP90AA1 2910 4876
HSP90AB1 585 829
HSP90B1 4171 7729
HSPA1A -3404 1113
HSPA1B 1982 755
HVCN1 -1080 1434
ICAM2 -1409 987
ICAM3 -4505 907
IDH1 2514 3293
IFIH1 4706 4725
IGF2R -3584 -23
IKBKB -64 965
IKBKE -2618 5976
ILF2 -978 -352
IMPDH1 -2518 6
IMPDH2 -4240 5354
IQGAP1 -1470 375
IQGAP2 1280 2780
IRAK2 -3392 7837
IRAK3 -1011 2788
IRF3 -2216 2803
IRF7 4284 6617
ISG15 4605 -542
IST1 971 1933
ITCH 2437 6864
ITGAL -224 4422
ITGAV 805 3287
ITGB2 -4278 750
ITK 694 -351
ITPR1 918 6634
ITPR2 2226 4474
ITPR3 643 2887
JUN -2852 2775
KCMF1 -973 -492
KCNAB2 -4227 5929
KPNB1 3755 5921
KRAS 4256 4020
LAIR1 -1241 6753
LAMP1 -4288 7982
LAMTOR1 -4490 -649
LAMTOR2 -4374 -288
LAMTOR3 3009 6767
LAT2 -3539 6621
LCK -1530 2504
LCP2 3695 -275
LGMN -1739 6394
LIMK1 -2745 -632
LPCAT1 -2221 -422
LRRFIP1 2577 4832
LTA4H -792 5719
MALT1 1826 7675
MAN2B1 -3851 7279
MANBA 2201 4780
MAP2K1 -3476 -148
MAP2K3 -3178 38
MAP2K4 569 3168
MAP2K6 2656 2172
MAP2K7 -3762 2099
MAP3K1 449 3830
MAP3K14 377 1388
MAP3K7 2598 3854
MAP3K8 68 6380
MAPK1 -664 2770
MAPK14 -471 2235
MAPK3 -4544 -479
MAPK7 -1945 3019
MAPK8 -584 6176
MAPK9 -2019 1159
MAPKAPK2 -3852 1423
MAPKAPK3 -2308 58
MAVS -2479 5467
MEF2A 2373 7468
MIF -3978 2447
MLEC -1044 5334
MMP25 -42 6417
MNDA 2315 1449
MPO -3624 347
MUC1 -313 6805
MUC12 3751 4013
MUC5B 516 -838
MVP -2199 8026
MYD88 1478 2762
MYH9 -3031 3393
MYO9B -1527 3151
NAPRT 94 -73
NBEAL2 -1618 5626
NCF4 -3240 -141
NCK1 1391 1103
NCKAP1L 731 1935
NCKIPSD -3825 8021
NCSTN -617 -457
NDUFC2 -3896 5333
NEU1 -270 3069
NF2 885 988
NFATC1 -2245 6752
NFATC2 -119 5200
NFATC3 902 4895
NFKB2 -1387 2526
NFKBIA -4003 3684
NFKBIB -3301 4669
NHLRC3 4564 5893
NIT2 3035 1160
NKIRAS1 -1738 4218
NKIRAS2 -3368 2015
NLRC5 3623 -234
NLRP1 -918 7076
NLRP3 -1832 6403
NLRX1 -3923 -361
NME2 -569 1739
NOD1 3795 2044
NOD2 500 2363
NOS3 301 4054
NPC2 407 6368
ORMDL3 -375 2581
OSCAR 1095 2321
OSTF1 -1276 7552
P2RX1 1242 2776
PA2G4 913 2838
PAFAH1B2 1055 4504
PAK1 2857 4972
PAK2 1920 2509
PANX1 1124 1294
PCBP2 -3544 1023
PDAP1 -4316 8125
PDPK1 -2227 145
PDXK -3053 4973
PELI1 882 1541
PELI2 -1029 8450
PELI3 -4476 3900
PFKL -3642 23
PGAM1 -3977 1593
PGM1 -3725 4577
PGM2 -1834 3355
PIK3CA 2842 3290
PIK3R1 -2375 5157
PIK3R2 -1983 5365
PIK3R4 2129 2082
PIN1 -4273 3781
PKM -3743 1481
PLA2G6 -2398 2570
PLAC8 1529 3818
PLAU -3032 5301
PLAUR -1591 4328
PLCG1 345 5809
PLCG2 239 6178
PLD1 106 2196
PLD3 -2683 2245
PLEKHO2 -433 6305
PNP 1599 2166
POLR1C 925 2660
POLR1D -320 3948
POLR2E -4392 2995
POLR2F -4196 6542
POLR2H -3384 7582
POLR2K 3044 2463
POLR3A 2330 3852
POLR3C 3883 8002
POLR3D 149 182
POLR3E -3071 6454
POLR3F 2742 7929
POLR3G 1114 7045
POLR3GL -1161 233
POLR3H -3788 6332
POLR3K 1853 713
PPIA -2974 5622
PPIE 2119 6766
PPP2CA -120 7715
PPP2CB 1948 15
PPP2R1B 2397 612
PPP2R5D -853 5740
PPP3CA -904 1251
PPP3CB 2850 5276
PPP3R1 -430 5024
PRCP -1258 6367
PRDX6 -3456 4160
PRKACA -2849 3985
PRKACB 1232 7740
PRKCD -1518 8196
PRKCE 3351 7129
PRKCQ -36 3938
PRKCSH -4375 5320
PRKDC 84 8143
PRTN3 -4397 8385
PSAP -1274 1290
PSEN1 1406 1724
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PSTPIP1 -3996 2324
PTGES2 -3345 -437
PTK2 -271 2498
PTPN11 404 3777
PTPN4 1197 1843
PTPN6 -353 2545
PTPRC 3435 1766
PTPRJ -2585 6883
PTPRN2 -1403 1646
PYCARD -2341 3155
PYGB -3255 -230
QPCT -2208 1848
QSOX1 -4014 6811
RAB10 485 1029
RAB14 2975 1868
RAB18 3153 1168
RAB24 1856 260
RAB27A 1452 7285
RAB37 1031 7555
RAB3A -3984 3520
RAB3D -1802 5964
RAB4B -2921 7798
RAB5B -1974 1215
RAB5C -4148 2996
RAB6A 2540 6447
RAB7A -2395 -526
RAC1 1432 7511
RAC2 -3560 6838
RAF1 -549 4294
RAP1A 3605 2618
RAP1B 2528 6154
RAP2B -802 6584
RASGRP1 2213 3250
RASGRP2 -2703 4912
RBSN -1007 7900
RELA -3471 5749
RELB -2948 4196
RHOA -152 1886
RHOF -1515 3524
RHOG -3137 3983
RIPK3 1481 1798
RNASET2 -1268 737
RNF125 -133 4942
RNF135 -785 2681
RNF216 -2886 1267
ROCK1 3813 2216
RPS27A -4344 2492
RPS6KA1 -2403 6292
RPS6KA2 -1652 6457
RPS6KA5 4565 7378
S100A11 -778 3968
S100P -3074 632
SARM1 -89 8170
SCAMP1 2211 7830
SDCBP 183 7446
SERPINB1 -1145 -242
SERPINB6 -4001 8005
SHC1 1742 7320
SIGIRR -2702 8367
SIKE1 4594 957
SKP1 2353 3193
SLC11A1 -651 1284
SLC15A4 2252 -651
SLC27A2 4187 3284
SLC2A3 -2809 4149
SLC44A2 -3167 1456
SLCO4C1 2126 1680
SNAP23 1502 8001
SNAP29 -3994 6080
SOCS1 -1415 5666
SOS1 4314 3280
SPTAN1 -2478 372
SRC -1513 -92
SRP14 428 5822
STAT6 -831 3396
STBD1 -811 6139
STK10 -2343 3483
STK11IP -4039 4548
STOM 531 -764
SUGT1 3040 6398
SURF4 -3281 5239
SVIP 1816 4144
SYK -2039 3901
TAB2 2294 -858
TANK 4107 5700
TAX1BP1 3115 1939
TBC1D10C -3824 3156
TBK1 4506 6515
TCIRG1 -2718 4563
TEC 1018 2883
TICAM1 1419 1217
TIFA 1272 8199
TIRAP -1045 3375
TLR1 2170 2637
TLR2 1473 6797
TLR3 2791 6792
TLR5 938 3926
TLR6 -989 -596
TLR9 -3429 -408
TMBIM1 -3833 2141
TMC6 -1264 1587
TMEM179B -614 1551
TMEM30A 1804 7713
TMEM63A 1468 1374
TNFAIP3 -3405 1877
TNFRSF1B -2234 1257
TNIP2 -2999 798
TOLLIP -4034 1238
TOM1 -4294 5194
TRAF2 2444 5299
TRAF3 -2865 3518
TRAF6 2707 6566
TRAPPC1 -2838 4015
TREX1 1908 2332
TRIM21 3278 -41
TRIM25 3559 6656
TRIM56 3429 2983
TRPM2 -3545 7785
TSPAN14 -1761 924
TUBB -254 3715
TUBB4B -1808 6419
TXK -1624 2769
TXN -441 339
TXNDC5 3742 7527
TXNIP 508 3975
TYROBP -3335 835
UBA3 3227 724
UBA52 -4076 4404
UBA7 1772 3041
UBB -3235 564
UBC -1858 2635
UBE2D1 273 4705
UBE2D2 -1452 4272
UBE2D3 1741 2455
UBE2K 2869 7187
UBE2L6 4162 765
UBE2M -4533 5170
UBE2N 2933 6764
UBE2V1 40 4586
UNC13D -2842 484
UNC93B1 813 8145
VAMP8 -4404 3389
VAPA 246 3839
VAT1 -4168 1433
VAV1 -3536 6946
VAV2 780 7727
VAV3 -3913 8297
VCL -2203 1837
VCP -3583 7877
VRK3 665 5208
VTN -464 2513
WASF1 -2311 763
WASF2 -1673 1239
WASL 3043 7402
WIPF1 -1158 2905
WIPF2 1628 568
XRCC5 475 3525
XRCC6 -2419 2815
YES1 1814 -624
YPEL5 1584 -147
ZBP1 4600 518



Translation initiation complex formation

Translation initiation complex formation
metric value
setSize 47
pMANOVA 7.71e-10
p.adjustMANOVA 2.36e-08
s.dist 0.541
s.RNA -0.536
s.meth -0.0769
p.RNA 2.1e-10
p.meth 0.363




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
EIF3B -3751 -643
RPS23 -4143 -355
RPS8 -3241 -349

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 2834 6703
EIF2S2 2873 5131
EIF3A -322 188
EIF3B -3751 -643
EIF3E 603 4012
EIF3F -4422 1788
EIF3G -4464 1822
EIF3H -2933 5015
EIF3I -4163 2663
EIF3J 3604 3059
EIF3K -3579 8409
EIF3L -4426 6698
EIF3M 1553 7241
EIF4A1 -2281 5352
EIF4A2 3092 5327
EIF4B -3478 3082
EIF4E 3927 5614
EIF4G1 -3207 3220
EIF4H -4497 3675
FAU -4443 5991
PABPC1 1108 3737
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692



Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
metric value
setSize 47
pMANOVA 1.75e-09
p.adjustMANOVA 5.24e-08
s.dist 0.531
s.RNA -0.528
s.meth -0.0613
p.RNA 3.87e-10
p.meth 0.468




Top 20 genes
Gene RNA meth
RPS2 -4547 -712
EIF3B -3751 -643
RPS23 -4143 -355
RPS8 -3241 -349

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 2834 6703
EIF2S2 2873 5131
EIF3A -322 188
EIF3B -3751 -643
EIF3E 603 4012
EIF3F -4422 1788
EIF3G -4464 1822
EIF3H -2933 5015
EIF3I -4163 2663
EIF3J 3604 3059
EIF3K -3579 8409
EIF3L -4426 6698
EIF3M 1553 7241
EIF4A1 -2281 5352
EIF4A2 3092 5327
EIF4B -3478 3082
EIF4E 3927 5614
EIF4G1 -3207 3220
EIF4H -4497 3675
EIF5 2849 7143
FAU -4443 5991
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692



Disease

Disease
metric value
setSize 929
pMANOVA 7.07e-09
p.adjustMANOVA 2.06e-07
s.dist 0.122
s.RNA -0.122
s.meth 0.00531
p.RNA 8.99e-10
p.meth 0.79




Top 20 genes
Gene RNA meth
FURIN -4531 8374
BRK1 -4516 8055
MAP2K2 -4508 8056
ARF1 -4250 8404
ADCY9 -4217 8419
RPS12 -4451 7699
RPL8 -4481 7647
POLR2G -4186 8051
HBEGF -4045 8169
VAV3 -3913 8297
RPL18 -4194 7741
MVB12A -4099 7863
RPL36AL -4421 7261
FZD8 -4318 7333
GALE -3789 8229
SPON2 -4005 7714
NCKIPSD -3825 8021
ANAPC11 -4328 7059
RCC1 -4524 6687
DVL3 -3607 8314

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
ABCA1 -3141 7256
ABCB6 -3664 4862
ABCD4 -1494 5999
ABI1 3918 523
ABI2 2261 1460
ABL1 -2249 5977
ACACA -369 4853
ACTB -2121 4265
ACTG1 -3714 6428
ACTR2 2174 4951
ACTR3 1312 4499
ACY1 -1455 4493
ADAM10 419 3603
ADAM17 2413 4714
ADAMTS10 -2678 6121
ADAMTS13 705 2178
ADAMTS17 -891 -518
ADAMTS6 3919 873
ADAMTSL4 1501 -696
ADAMTSL5 1057 3441
ADCY4 757 6234
ADCY7 -1798 2400
ADCY9 -4217 8419
ADM -2837 7632
ADORA2A -1548 8364
ADRB2 -1002 5274
AGGF1 1968 771
AGK 2275 6036
AGRN 3879 3516
AGTRAP -3228 4549
AHCY -4145 1896
AHCYL1 331 6911
AKAP9 4474 2144
AKT1 -4078 4230
AKT1S1 -4339 5797
AKT2 -3887 3475
ALG11 366 1937
ALG12 -1315 3002
ALG14 4048 4558
ALG2 3834 1109
ALG3 -1939 5746
ALG6 4197 609
ALG8 4047 1155
ALG9 2042 3921
ANAPC1 -351 3351
ANAPC10 2240 -306
ANAPC11 -4328 7059
ANAPC15 -4465 2693
ANAPC16 -376 6873
ANAPC2 -2785 1387
ANAPC4 4302 1495
ANAPC5 1020 3142
ANAPC7 4469 869
ANTXR2 -3667 -806
AP1B1 -3618 7607
AP1G1 1472 6363
AP1M1 -4274 2151
AP1S3 2348 5075
AP2A1 -2951 1895
AP2M1 -4431 5734
AP2S1 -3760 3997
AP3B1 -171 2427
APBB1IP -267 5837
APC 1780 6253
APH1A -4262 1663
APH1B 3033 2594
APP -2922 7596
ARF1 -4250 8404
ARID4A 4099 5298
ARID4B 3983 877
ARPC1B -3966 2843
ARPC2 -83 5703
ARPC3 1376 4838
ARPC5 804 2343
ARRB1 -3947 3187
ARRB2 -3734 4636
ARSB 809 6874
ATG7 -2328 1263
ATP1A1 -1037 5489
ATP1A3 865 5196
ATP1B1 378 8146
ATP1B3 2449 -277
ATP6V1H -1097 5715
AXIN1 -3846 6798
B2M 2830 3658
B3GALT6 -3557 7118
B3GAT3 -3620 5844
B4GALT1 -2892 7957
B4GALT7 -1253 5460
B4GAT1 -3374 805
BAD -4478 6601
BAG4 1979 2195
BAIAP2 -2723 6308
BANF1 -4022 4199
BARD1 2971 7159
BCL2L1 37 5923
BCL2L11 -354 5324
BCR -2472 5468
BECN1 5 7998
BIN2 -3333 3315
BRAF 2798 80
BRAP 3780 8090
BRCA1 3184 943
BRD4 2237 -833
BRK1 -4516 8055
BRMS1 -4306 5625
BSG -4161 758
BTD 36 3162
BTRC -2202 66
C1GALT1 4562 1549
C1QBP -4098 2074
C3AR1 4556 1729
CALM1 1471 3996
CALR 1298 3555
CAMK2D -1254 3808
CAMK2G -669 31
CAMK4 -1023 2737
CANX 130 7355
CAPN1 -3796 5491
CAPN2 2156 444
CAPNS1 -2076 6108
CASP1 3166 -381
CASP8 637 5804
CASP9 165 703
CAST -1395 2867
CBL -730 7616
CBX1 -656 4266
CCNC 3746 2192
CCND1 3127 3568
CCND2 1483 -618
CCND3 -3454 2914
CCNE1 4347 6755
CCNE2 144 5076
CCNH 4325 5990
CCNK 3396 2118
CCNT1 962 211
CD247 -3063 3173
CD320 -968 1192
CD4 -3009 6004
CDC16 2944 7052
CDC23 3474 4397
CDC25A -1699 5081
CDC25B 1100 1268
CDC42 2291 7063
CDK2 360 6577
CDK4 -3226 6700
CDK5 -312 4651
CDK5R1 -3377 7721
CDK6 3156 2094
CDK7 3900 3672
CDK8 2703 2327
CDK9 -4219 6663
CDKN1A 205 7579
CDKN1B -296 1658
CDKN2A 746 4878
CEBPD -3979 1324
CHD3 -3131 1467
CHD4 -1096 1893
CHMP1A -3080 982
CHMP2A -3792 7013
CHMP2B 2766 5744
CHMP3 314 -59
CHMP4A 1988 1773
CHMP4B -4368 4124
CHMP5 4584 1922
CHMP6 -4415 1561
CHMP7 -84 6937
CHST14 -2833 4687
CHSY1 -438 1619
CHUK 1417 2714
CLCN6 2420 115
CLTA -2759 1476
CLTC -705 2682
CNTRL 4546 6120
COMT -4115 -295
CORO1A -4177 3099
CPSF4 -3019 7194
CPSF6 2803 6651
CRBN 3913 5723
CREB1 2684 5066
CREBBP -2131 6830
CRK 2137 5956
CSK -3407 2005
CSNK1A1 1353 2052
CTBP1 -3205 8318
CTDP1 -4073 1498
CTNNB1 -867 6731
CTNND1 4276 2992
CTSA -3502 2093
CTSL 3221 8394
CUL1 4686 1579
CUL5 4403 5417
CUX1 -540 3147
CXCR4 -2975 6685
CYBA -3513 5379
CYFIP1 -2919 8327
CYFIP2 765 4244
CYP2R1 3521 4409
CYP2U1 3692 3610
CYP4F22 4545 -386
DAD1 -725 -641
DAG1 -1582 2764
DAXX 1297 3531
DBP -2519 6319
DCXR -1585 991
DDX5 -1978 1749
DERL1 1277 7619
DERL2 2730 2204
DERL3 -1217 3406
DHDDS -971 4743
DNAJC3 1878 8319
DNMT1 -1875 3743
DNMT3A -1812 1532
DNMT3B -881 8042
DOLK 517 7464
DPAGT1 -442 2058
DPEP2 -14 5071
DPM1 3631 7963
DPM2 -1663 3940
DPM3 -4286 6882
DUSP10 198 1249
DUSP16 -2161 -243
DUSP6 300 7754
DUSP7 -2891 6463
DUT -3423 4927
DVL1 -4517 5359
DVL2 -2904 646
DVL3 -3607 8314
DYNC1H1 -621 1172
DYNC1I2 -163 261
DYNC1LI1 2931 6081
DYNC1LI2 961 3137
DYNLL1 -1533 5391
DYNLL2 -2741 3308
E2F1 2805 1130
E2F2 61 3021
E2F3 2817 5634
EDEM2 -1755 1857
EED 3870 2932
EEF2 -4461 1316
EIF2AK2 4762 189
ELL -2931 2306
ELMO1 -2858 4458
ELMO2 965 3635
ENO1 -3898 3952
ENTPD1 256 7155
ENTPD5 4492 3843
EP300 1012 3364
EPS15 4410 4996
ERBB2 -1613 7893
ERCC2 -1586 1785
ERCC3 1777 3558
ERLEC1 2983 6281
ERLIN1 708 5985
ERLIN2 -3330 6330
ESR2 1131 1955
ETV6 3117 4949
EXT1 -504 7581
EXT2 -1332 7940
EZH2 4487 4485
F12 -3073 1764
FADD -1355 2280
FAU -4443 5991
FBXW7 -370 6314
FDX1 2921 5894
FDXR 1028 3311
FEN1 -1067 5510
FGF9 -2622 6748
FGFR1OP2 4411 4306
FGR -2747 6452
FIP1L1 812 2997
FKBP1A -714 6135
FKBP4 -1987 4677
FLT3LG -1756 4467
FOXO1 -1206 821
FOXO3 -3182 7336
FRS2 2876 165
FURIN -4531 8374
FUT8 3256 7583
FXR1 845 2494
FXYD7 -2733 -773
FYN -1981 2811
FZD5 1145 8137
FZD6 -1036 8192
FZD7 2032 2395
FZD8 -4318 7333
FZR1 -1998 7430
G6PC3 -2125 5378
GAA -3165 1089
GAB2 -2379 350
GALE -3789 8229
GALK1 -3768 1849
GALNS -1700 6572
GALNT12 957 -202
GALNT3 4434 7931
GALT 116 3231
GANAB -4170 2335
GATAD2A -1612 7033
GATAD2B 2313 7362
GCLC 3768 2282
GCLM -726 1772
GFPT1 4398 -199
GGCX -277 5111
GGT1 -3229 -730
GIPR -274 462
GLB1 -1934 7211
GNAI2 -3426 5421
GNAI3 1484 705
GNAS -2079 -276
GNB1 -2758 -391
GNB2 -2980 6049
GNB4 3395 8172
GNB5 373 5796
GNE 3806 6163
GNG2 92 4290
GNG3 4104 8393
GNG4 3296 7006
GNG5 -204 3751
GNG7 619 -475
GNGT2 -1460 -71
GNS -638 5474
GOLGA2 -1689 1717
GOLGA4 3863 6223
GOLGB1 2303 2462
GPC2 -1960 5692
GPS2 -1042 1242
GRB2 -2429 5992
GRSF1 662 1474
GSDMD -2430 4189
GSK3A -3011 4821
GSK3B -648 3637
GSS -2750 7383
GTF2A1 2271 3947
GTF2A2 1864 4288
GTF2B 4279 1777
GTF2E2 2178 2527
GTF2F1 -3630 1349
GTF2F2 199 4275
GTF2H3 327 8269
GTF2H4 -2613 6171
GTF2H5 2768 1888
GUSB -2990 4887
GYG1 -3201 6468
GYS1 -1743 4356
HBEGF -4045 8169
HDAC1 -483 4910
HDAC10 -2446 6354
HDAC11 -2580 7767
HDAC2 357 4593
HDAC3 -2463 8308
HDAC4 -3000 1782
HDAC5 -3234 627
HDAC7 -2210 3814
HEXA -3270 6940
HEXB -1501 7586
HEY2 -3753 -426
HGS -218 2237
HGSNAT -323 355
HHAT -291 6758
HK1 -3121 2185
HLA-A -4258 2274
HLCS 1677 402
HMG20B -3402 5116
HMGA1 -3906 5560
HMGB1 981 2532
HNRNPK -1202 5618
HRAS -2578 1490
HRH2 221 7921
HSP90AA1 2910 4876
HSP90AB1 585 829
HSPA1A -3404 1113
HYAL1 3808 -580
IDH1 2514 3293
IDUA -2710 7884
IFNAR1 2643 6059
IFNAR2 -1233 1950
IFNGR1 -132 4337
IFNGR2 1058 6521
IKBKB -64 965
IL6R -1261 6551
IMPDH1 -2518 6
IMPDH2 -4240 5354
IPO5 -719 8363
IQGAP1 -1470 375
IRS1 -2324 4427
IRS2 -4230 5305
ISG15 4605 -542
ITGA4 2309 4664
ITPR1 918 6634
ITPR2 2226 4474
ITPR3 643 2887
JAK1 -2780 6986
JAK2 4742 6248
JUN -2852 2775
KANK1 -2731 7295
KAT2A -124 2984
KAT2B 4300 630
KCNJ11 -741 -427
KDM1A -1741 4065
KHK -2670 -50
KPNA1 2524 6172
KPNA2 2087 843
KPNA3 3432 1404
KPNA4 3745 8152
KPNA5 4407 1689
KPNB1 3755 5921
KRAS 4256 4020
KSR1 1428 2630
LCK -1530 2504
LFNG -1668 6024
LIG1 -689 1862
LIG4 4297 6928
LMBRD1 1666 1143
LMNA -2829 -409
LMNB1 3532 4104
LRP5 -4144 -743
LRP6 -2835 7965
LRRFIP1 2577 4832
MAML1 -1344 5639
MAML2 -3917 2218
MAML3 -2225 8147
MAN1B1 -3220 1152
MAN2A1 2786 3683
MAP2K1 -3476 -148
MAP2K2 -4508 8056
MAP2K3 -3178 38
MAP2K4 569 3168
MAP2K6 2656 2172
MAP2K7 -3762 2099
MAP3K11 -1648 2576
MAPK1 -664 2770
MAPK14 -471 2235
MAPK3 -4544 -479
MAPK8 -584 6176
MAPKAP1 498 5528
MARK3 3892 7759
MBD3 -3800 7276
MCCC1 -396 8183
MCCC2 4610 5255
MDM2 4685 1092
MGAT1 -4026 3340
MGAT2 -1681 5371
MGAT4A -1115 3003
MGAT4B -3344 2849
MGAT5 -3674 6294
MIB1 150 4098
MLST8 -2698 3421
MMAA 4465 2913
MMAB 1052 3567
MMACHC 2697 -173
MMADHC 3231 4922
MNAT1 1367 2609
MOGS -3527 4407
MPDU1 393 -365
MPI 2518 4897
MPRIP -3732 4906
MSH2 4623 7030
MSH3 -2561 2051
MSH6 2447 6116
MTA2 -1649 2515
MTA3 -873 857
MTOR -2466 1240
MTR 2390 3011
MTRR 3249 5670
MUC1 -313 6805
MUC12 3751 4013
MUC5B 516 -838
MUTYH -1164 4693
MVB12A -4099 7863
MYD88 1478 2762
MYH9 -3031 3393
MYO18A -1166 -356
MYO9B -1527 3151
NAGLU -3759 7426
NAPEPLD 4523 1842
NCBP1 4364 6545
NCBP2 4238 3728
NCK1 1391 1103
NCKAP1L 731 1935
NCKIPSD -3825 8021
NCOR1 1467 1101
NCOR2 -3180 580
NCSTN -617 -457
NDC1 1276 -274
NEDD4L -1595 223
NEIL3 -423 1755
NELFA -706 6889
NELFB -4311 5472
NELFCD -176 4159
NELFE -2330 8447
NEU1 -270 3069
NF1 2659 3367
NFKB2 -1387 2526
NFKBIA -4003 3684
NHLRC1 -2426 6568
NLRP3 -1832 6403
NMT1 3786 5677
NMT2 3541 2421
NOTCH1 -2630 2429
NOTCH4 934 3925
NOXA1 -1390 6268
NR3C1 795 4250
NR4A1 2281 3392
NTHL1 -1203 1057
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
NUS1 1208 346
OGG1 -465 3282
OS9 -2489 1598
P2RX4 -2366 621
PABPN1 -3354 7278
PACS1 -1903 5954
PAK2 1920 2509
PAPSS1 446 6222
PARP1 -684 377
PARP10 4138 249
PARP14 4751 288
PARP16 -2060 3444
PARP4 3939 2826
PARP6 -577 7359
PARP8 1448 -314
PARP9 4759 3387
PC -4364 1255
PCCB -2023 3538
PDCD6IP 3551 3740
PDPK1 -2227 145
PEBP1 983 4800
PGM1 -3725 4577
PHB -4308 6929
PHF21A -2599 3544
PIK3AP1 484 4979
PIK3CA 2842 3290
PIK3CD -2911 153
PIK3R1 -2375 5157
PIK3R2 -1983 5365
PIK3R3 3664 3533
PIK3R4 2129 2082
PIM1 54 2994
PLCG1 345 5809
PLCG2 239 6178
PLK2 -1310 8395
PML 4203 1165
PMM2 2128 550
PMS2 2595 2725
POLA2 3566 5083
POLR2A -851 -175
POLR2B 647 1497
POLR2C -2229 4506
POLR2D 2056 1352
POLR2E -4392 2995
POLR2F -4196 6542
POLR2G -4186 8051
POLR2H -3384 7582
POLR2I -4069 6360
POLR2K 3044 2463
POM121 -1366 5167
POM121C -3196 5663
POMGNT1 -631 4077
POMT1 654 4432
POMT2 -3541 7780
PPIA -2974 5622
PPP1CB 2999 -226
PPP1CC 3626 3213
PPP2CA -120 7715
PPP2CB 1948 15
PPP2R1B 2397 612
PPP2R5A 2453 1231
PPP2R5B 339 7072
PPP2R5C 1399 5914
PPP2R5D -853 5740
PPP2R5E 2347 2424
PRDX1 1389 4095
PRDX2 -2836 6462
PRIM1 3973 5416
PRIM2 1185 276
PRKACA -2849 3985
PRKACB 1232 7740
PRKAR1A 538 3914
PRKAR1B -2289 -687
PRKAR2A -142 532
PRKCSH -4375 5320
PRR5 -3441 4592
PSEN1 1406 1724
PSEN2 -29 4736
PSENEN -1546 5332
PSIP1 3853 2179
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PSTPIP1 -3996 2324
PTEN 1170 3667
PTGER2 -2655 7393
PTGER4 486 3095
PTGES3 3489 2735
PTK2 -271 2498
PTPN11 404 3777
PTPN12 -1899 -606
PYCARD -2341 3155
QKI -487 1600
RAB5A 3764 1760
RAB7A -2395 -526
RAC1 1432 7511
RAC2 -3560 6838
RAE1 1852 710
RAF1 -549 4294
RAN 136 2287
RANBP1 -977 1651
RANBP2 3105 4436
RANGAP1 -1846 6695
RAP1A 3605 2618
RAP1B 2528 6154
RB1 1147 1518
RBBP4 1636 2574
RBPJ 1401 3986
RBX1 776 6226
RCC1 -4524 6687
RCOR1 -1197 4222
RELA -3471 5749
REST 2492 2105
RFT1 175 6089
RHBDF2 -1568 4216
RHOG -3137 3983
RICTOR 3910 4624
RNF185 304 2853
RNF213 4054 3702
RNF5 -3215 -777
RNGTT 3198 1738
RNMT 3661 2751
ROCK1 3813 2216
RPL10A -2939 3614
RPL11 -3250 4777
RPL13 -3066 2572
RPL13A -2968 1453
RPL14 -4333 1652
RPL15 -4094 2869
RPL17 -4011 1601
RPL18 -4194 7741
RPL18A -4215 756
RPL22 -3672 5694
RPL23 -3675 5721
RPL23A -2305 7846
RPL26 -3983 4874
RPL26L1 -2614 2114
RPL27A -4289 5331
RPL28 -2689 2136
RPL29 -4412 4940
RPL3 -4400 363
RPL31 -4354 498
RPL32 -3962 4794
RPL34 -3046 913
RPL35 -3905 2921
RPL36 -4456 -158
RPL36AL -4421 7261
RPL37 -4545 3446
RPL37A -4352 1854
RPL38 -4500 4360
RPL39L -2194 4235
RPL4 -3442 1004
RPL41 -4223 4810
RPL6 -1557 3365
RPL7 -4015 5023
RPL8 -4481 7647
RPL9 -2051 4325
RPLP0 -4361 5098
RPLP1 -4437 4276
RPLP2 -4537 3699
RPN1 -3275 6578
RPN2 -618 3798
RPS10 -4432 2364
RPS11 -4386 1206
RPS12 -4451 7699
RPS15 -4117 1906
RPS15A -4210 1664
RPS16 -4363 4287
RPS18 -3781 4827
RPS19 -4225 1409
RPS2 -4547 -712
RPS20 -2942 4760
RPS23 -4143 -355
RPS24 -2127 6177
RPS25 -3831 139
RPS26 -199 6119
RPS27A -4344 2492
RPS27L 3828 2937
RPS28 -4279 17
RPS29 -4513 3935
RPS3 -4376 4069
RPS3A -1883 4040
RPS5 -4158 3327
RPS6 -3904 4750
RPS6KB2 -1597 6145
RPS7 -3891 3942
RPS8 -3241 -349
RPS9 -4211 1947
RPSA 1465 692
S1PR1 784 -333
SAP18 -1992 6235
SAP30 -1829 5426
SAP30L -3018 5401
SDC4 -3045 2476
SEC13 -2693 7357
SEH1L 3110 6644
SEL1L 409 2874
SFPQ 1843 6453
SH3GL1 -3989 6433
SHC1 1742 7320
SHOC2 2053 7670
SIGMAR1 -863 5834
SIN3A -798 1529
SKP1 2353 3193
SKP2 4608 3439
SLC11A2 -1204 5178
SLC12A6 -3156 7629
SLC16A1 2318 3079
SLC17A5 1271 990
SLC20A2 -4201 120
SLC22A5 -3287 8258
SLC24A4 -845 -572
SLC25A4 2217 7484
SLC26A2 323 7114
SLC27A4 -3467 8421
SLC29A3 -3861 -43
SLC2A1 -1237 2227
SLC2A9 -2822 -648
SLC33A1 3887 2706
SLC35A1 1121 1581
SLC35A3 4560 4828
SLC35C1 -150 7950
SLC35D1 -856 8003
SLC37A4 243 2578
SLC39A4 -2470 -747
SLC3A2 -3776 497
SLC5A5 -131 1265
SMAD2 2851 1116
SMAD3 13 5325
SMAD4 3942 777
SND1 -3413 -126
SNF8 -3710 7542
SNW1 3124 3991
SOD2 1499 6344
SOS1 4314 3280
SPON2 -4005 7714
SPRED1 4313 6876
SPRED2 -1608 7029
SPRED3 1735 7891
SPTBN1 -2562 7757
SRC -1513 -92
SRD5A3 2902 2425
SSRP1 -2405 2951
ST3GAL1 -2314 5875
ST3GAL2 -2611 2056
ST3GAL3 -1465 3508
ST3GAL4 -3567 2599
ST6GAL1 1268 3705
ST6GALNAC3 -2985 7567
ST6GALNAC4 -387 1062
STAM 1591 1978
STAM2 4383 4717
STAT1 4650 956
STAT2 4692 3486
STAT3 1093 7085
STAT5A -2573 -568
STAT5B -2539 7793
STRN 1017 3607
STT3A 533 1991
STX1A -2317 1045
STX1B 3311 865
SUDS3 2505 3071
SUGT1 3040 6398
SUMO1 2148 4431
SUPT16H 777 2239
SUPT4H1 -1880 7521
SUPT5H -2338 5377
SYK -2039 3901
SYVN1 1626 4741
TAF10 -2924 2748
TAF11 4222 -261
TAF12 1194 486
TAF13 3766 3314
TAF15 -3822 7204
TAF2 4458 1412
TAF3 3463 7268
TAF4 -51 5640
TAF4B 866 716
TAF5 2433 3006
TAF6 -1891 4411
TAF7 745 6649
TAF9 3601 759
TALDO1 -2422 2955
TBK1 4506 6515
TBL1XR1 1832 1367
TBXAS1 -1594 8065
TCEA1 2925 2742
TCF7L2 4720 2013
TFDP1 1708 471
TFDP2 -2800 3770
TGFA -2423 7668
TGFB1 -3735 4353
TGFBR1 2002 5267
TGFBR2 -3592 6688
TICAM1 1419 1217
TIRAP -1045 3375
TLN1 -3378 2103
TLR1 2170 2637
TLR2 1473 6797
TLR3 2791 6792
TLR5 938 3926
TLR6 -989 -596
TLR9 -3429 -408
TNKS 3071 7230
TNKS2 2109 2734
TPMT 3015 -286
TPR 3482 5135
TPST1 507 6863
TPST2 -3145 3734
TRADD -2416 2061
TRAF2 2444 5299
TRAF3 -2865 3518
TRIM24 1173 4718
TRIM27 2299 5362
TRIM28 -4090 3417
TRIP11 2502 4645
TSC2 -953 5090
TSG101 1806 1787
TUBB -254 3715
TXN -441 339
TXNIP 508 3975
TXNRD1 -917 214
TYK2 -1723 1909
UBA52 -4076 4404
UBAP1 -2537 958
UBB -3235 564
UBC -1858 2635
UBE2C -2854 1584
UBE2D1 273 4705
UBE2E1 -754 3149
UBE2I -1908 3654
UBE2S 707 -550
UNC93B1 813 8145
UVRAG 4460 1515
VAMP1 201 4166
VAMP2 -146 536
VAV1 -3536 6946
VAV2 780 7727
VAV3 -3913 8297
VCL -2203 1837
VCP -3583 7877
VEGFA -3785 832
VHL -1931 2728
VIPR1 -2453 1741
VPS25 -3249 1068
VPS28 -4254 6113
VPS33B -2408 1344
VPS36 4448 285
VPS37A 3854 7391
VPS37B -3422 2190
VPS37C -416 4251
VPS4A -4114 1747
VTA1 3696 6287
WASF1 -2311 763
WASF2 -1673 1239
WASL 3043 7402
WDR48 4291 1915
WIPF1 -1158 2905
WIPF2 1628 568
XPO1 4524 5628
XRCC4 1549 6580
XRCC5 475 3525
XRCC6 -2419 2815
YES1 1814 -624
YWHAB 3503 4090
YWHAE 431 6202
ZBP1 4600 518
ZC3HAV1 3905 1580
ZCRB1 3807 2608
ZFYVE9 -2607 3530
ZMYM2 4520 4382



Interferon Signaling

Interferon Signaling
metric value
setSize 142
pMANOVA 2.14e-08
p.adjustMANOVA 6.07e-07
s.dist 0.291
s.RNA 0.289
s.meth -0.0344
p.RNA 3e-09
p.meth 0.481




Top 20 genes
Gene RNA meth
EIF4E3 4068 -728
ISG15 4605 -542
BST2 2756 -711
PDE12 3865 -503
USP18 4758 -387
MX2 4729 -241
IFIT2 4740 -227
OAS1 4653 -193
PPM1B 3027 -194
NDC1 1276 -274
ISG20 2841 -116
PTPN1 984 -296
TRIM21 3278 -41

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
ABCE1 3234 2902
ADAR 4395 5945
ARIH1 2852 5841
B2M 2830 3658
BST2 2756 -711
CAMK2D -1254 3808
CAMK2G -669 31
CD44 -2857 4410
DDX58 4744 2919
EGR1 -1081 7109
EIF2AK2 4762 189
EIF4A1 -2281 5352
EIF4A2 3092 5327
EIF4A3 -3458 5329
EIF4E 3927 5614
EIF4E2 -2507 2810
EIF4E3 4068 -728
EIF4G1 -3207 3220
EIF4G2 1388 6231
EIF4G3 1078 900
FLNB 392 3896
GBP3 2280 7707
HERC5 4748 1229
HLA-A -4258 2274
HLA-B -1024 513
HLA-C -217 6790
HLA-E -1278 3744
HLA-F -3700 -24
HLA-H -4103 7849
ICAM1 -2876 6201
IFI30 540 3554
IFI35 4501 208
IFI6 4660 920
IFIT1 4760 25
IFIT2 4740 -227
IFIT3 4761 7117
IFIT5 4680 7258
IFITM1 2862 818
IFNAR1 2643 6059
IFNAR2 -1233 1950
IFNGR1 -132 4337
IFNGR2 1058 6521
IP6K2 590 7313
IRF1 3543 5454
IRF2 3242 5323
IRF3 -2216 2803
IRF4 3077 4603
IRF5 -2147 8203
IRF7 4284 6617
IRF9 4691 5128
ISG15 4605 -542
ISG20 2841 -116
JAK1 -2780 6986
JAK2 4742 6248
KPNA1 2524 6172
KPNA2 2087 843
KPNA3 3432 1404
KPNA4 3745 8152
KPNA5 4407 1689
KPNB1 3755 5921
MAPK3 -4544 -479
MT2A 1283 3780
MX1 4733 1151
MX2 4729 -241
NDC1 1276 -274
NEDD4 1887 6220
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
OAS1 4653 -193
OAS2 4750 3133
OAS3 4705 5423
OASL 4677 6420
PDE12 3865 -503
PIAS1 3517 7693
PIN1 -4273 3781
PLCG1 345 5809
PML 4203 1165
POM121 -1366 5167
POM121C -3196 5663
PPM1B 3027 -194
PRKCD -1518 8196
PSMB8 1469 1753
PTPN1 984 -296
PTPN11 404 3777
PTPN2 2310 3176
PTPN6 -353 2545
RAE1 1852 710
RANBP2 3105 4436
RNASEL 3920 3080
RPS27A -4344 2492
SAMHD1 3450 7360
SEC13 -2693 7357
SEH1L 3110 6644
SOCS1 -1415 5666
SOCS3 -4424 698
SP100 4718 3034
STAT1 4650 956
STAT2 4692 3486
SUMO1 2148 4431
TPR 3482 5135
TRIM14 3204 1706
TRIM2 -3150 2382
TRIM21 3278 -41
TRIM22 4724 1106
TRIM25 3559 6656
TRIM26 1841 4604
TRIM35 -1638 4844
TRIM38 4617 5525
TRIM45 954 5188
TRIM46 553 3191
TRIM5 4700 5690
TRIM62 -521 6609
TRIM68 -1772 -335
TRIM8 -2756 4640
TYK2 -1723 1909
UBA52 -4076 4404
UBA7 1772 3041
UBB -3235 564
UBC -1858 2635
UBE2E1 -754 3149
UBE2L6 4162 765
UBE2N 2933 6764
USP18 4758 -387
XAF1 4768 4696



Metabolism of carbohydrates

Metabolism of carbohydrates
metric value
setSize 177
pMANOVA 2.24e-07
p.adjustMANOVA 6.21e-06
s.dist 0.245
s.RNA -0.236
s.meth 0.0658
p.RNA 6.64e-08
p.meth 0.133




Top 20 genes
Gene RNA meth
B3GNT7 -4107 7920
GALE -3789 8229
MAN2B1 -3851 7279
NAGLU -3759 7426
UST -4351 6034
TPI1 -3845 6828
B3GALT6 -3557 7118
B4GALT1 -2892 7957
HEXA -3270 6940
ENO3 -2663 8383
GPI -3307 6596
IDUA -2710 7884
B3GAT3 -3620 5844
GYG1 -3201 6468
CHPF2 -3681 5473
PGP -4249 4732
SEC13 -2693 7357
CHST2 -3908 4950
POM121C -3196 5663
UBA52 -4076 4404

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
ABCC5 -2923 4067
ADPGK 2655 2260
AGL 3703 2766
AGRN 3879 3516
AKR1A1 -2369 4797
AKR1B1 -4037 2326
ALDOA -3406 648
ALDOC 482 7310
ARSB 809 6874
B3GALT4 -2633 5384
B3GALT6 -3557 7118
B3GAT2 -409 7818
B3GAT3 -3620 5844
B3GNT2 3985 6205
B3GNT7 -4107 7920
B4GALT1 -2892 7957
B4GALT2 298 -162
B4GALT3 1504 2276
B4GALT4 271 4038
B4GALT5 209 5443
B4GALT6 -2272 5500
B4GALT7 -1253 5460
B4GAT1 -3374 805
CALM1 1471 3996
CD44 -2857 4410
CHP1 -2763 624
CHPF -533 5678
CHPF2 -3681 5473
CHST11 -3315 2817
CHST12 1583 6327
CHST14 -2833 4687
CHST2 -3908 4950
CHSY1 -438 1619
CRYL1 -2874 1437
CSGALNACT1 -1621 1521
CSGALNACT2 3709 323
DCXR -1585 991
DERA 2361 7436
DSE -2674 3771
DSEL 932 6534
ENO1 -3898 3952
ENO2 1370 5074
ENO3 -2663 8383
EXT1 -504 7581
EXT2 -1332 7940
FBP1 -1379 6919
FUT10 563 5277
FUT11 2341 6318
FUT4 -2128 5273
G6PC3 -2125 5378
GAA -3165 1089
GALE -3789 8229
GALK1 -3768 1849
GALT 116 3231
GAPDH -4297 1138
GLB1 -1934 7211
GLCE -1910 6213
GLYCTK -1642 6569
GNPDA1 -2461 2317
GNPDA2 1062 2466
GNS -638 5474
GOT1 2542 4943
GOT2 463 1040
GPC2 -1960 5692
GPI -3307 6596
GUSB -2990 4887
GYG1 -3201 6468
GYS1 -1743 4356
HEXA -3270 6940
HEXB -1501 7586
HK1 -3121 2185
HK2 -3614 1526
HMMR 816 3599
HS3ST3B1 -1727 8081
HS6ST1 -2841 1462
HYAL1 3808 -580
HYAL2 -3972 2095
HYAL3 -1535 3787
IDUA -2710 7884
KHK -2670 -50
MAN2B1 -3851 7279
MAN2B2 1485 6921
MAN2C1 -1928 4905
MANBA 2201 4780
MDH1 153 5775
MDH2 -3673 -832
NAGLU -3759 7426
NDC1 1276 -274
NDST2 -2442 -263
NHLRC1 -2426 6568
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
PAPSS1 446 6222
PC -4364 1255
PCK2 1840 3678
PFKFB2 1127 7652
PFKFB3 -2252 5953
PFKFB4 -2009 5420
PFKL -3642 23
PFKM -1897 6978
PFKP -1623 246
PGAM1 -3977 1593
PGD -3859 4560
PGLS -4388 3410
PGM1 -3725 4577
PGM2 -1834 3355
PGM2L1 -297 7574
PGP -4249 4732
PHKB 3424 2
PHKG2 -1343 748
PKM -3743 1481
POM121 -1366 5167
POM121C -3196 5663
PPP2CA -120 7715
PPP2CB 1948 15
PPP2R1B 2397 612
PPP2R5D -853 5740
PRKACA -2849 3985
PRKACB 1232 7740
PYGB -3255 -230
RAE1 1852 710
RANBP2 3105 4436
RPE 1456 4886
RPS27A -4344 2492
SDC4 -3045 2476
SEC13 -2693 7357
SEH1L 3110 6644
SHPK 131 6422
SLC25A1 -2860 4305
SLC25A11 -3194 3449
SLC25A12 1076 2412
SLC25A13 305 7294
SLC26A2 323 7114
SLC2A1 -1237 2227
SLC35B2 -3696 3060
SLC35B3 2593 875
SLC37A1 -136 -635
SLC37A2 -2843 6125
SLC37A4 243 2578
SLC9A1 -2736 996
SORD 706 4528
ST3GAL1 -2314 5875
ST3GAL2 -2611 2056
ST3GAL3 -1465 3508
ST3GAL4 -3567 2599
ST3GAL6 1909 8424
ST6GALNAC6 184 -547
TALDO1 -2422 2955
TKT -3915 1831
TPI1 -3845 6828
TPR 3482 5135
UBA52 -4076 4404
UBB -3235 564
UBC -1858 2635
UGP2 2913 2171
UST -4351 6034
XYLB -180 2353
XYLT1 -3919 4457
XYLT2 -2551 2519



Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
metric value
setSize 82
pMANOVA 1.52e-06
p.adjustMANOVA 4.13e-05
s.dist 0.329
s.RNA -0.327
s.meth -0.0328
p.RNA 3.15e-07
p.meth 0.608




Top 20 genes
Gene RNA meth
COX5B -3992 -244
NDUFAF5 -382 -133

Click HERE to show all gene set members

All member genes
RNA meth
COA1 2071 8256
COQ10A 467 7736
COQ10B 2636 5769
COX11 2934 3025
COX14 -3473 3855
COX16 3674 3560
COX19 3545 298
COX20 3562 3497
COX4I1 -3349 4535
COX5A -3813 3397
COX5B -3992 -244
COX6A1 -4298 1809
COX6B1 -2925 2356
COX6C -2174 2408
COX7A2L -489 5803
COX7C -3932 603
COX8A -4207 3949
CYC1 -3882 5829
CYCS 2102 2450
ECSIT -3238 6323
ETFA 2927 5795
ETFB -3171 3419
ETFDH 3116 7626
LRPPRC 1645 376
NDUFA10 -420 5793
NDUFA11 -2905 601
NDUFA12 -535 729
NDUFA13 -4479 5091
NDUFA2 -4444 3313
NDUFA3 -3482 7304
NDUFA4 -2791 2018
NDUFA5 3596 333
NDUFA6 -2212 4184
NDUFA7 -3515 2639
NDUFA8 -192 5072
NDUFA9 3168 7361
NDUFAB1 -2579 1043
NDUFAF1 2034 426
NDUFAF2 233 2075
NDUFAF3 -3892 1824
NDUFAF4 429 -161
NDUFAF5 -382 -133
NDUFAF6 3389 -482
NDUFB1 -4259 7880
NDUFB10 -4300 4926
NDUFB2 -4385 8398
NDUFB3 -1941 5110
NDUFB4 -2457 1638
NDUFB5 2482 3909
NDUFB7 -4010 4869
NDUFB9 -4179 4749
NDUFC1 -1837 2107
NDUFC2 -3896 5333
NDUFS1 229 -31
NDUFS2 -1914 57
NDUFS3 -3323 193
NDUFS4 128 6272
NDUFS5 -3876 5637
NDUFS6 -4343 6204
NDUFS7 -3319 5729
NDUFS8 -4040 102
NDUFV1 -3154 4359
NDUFV2 770 1025
NDUFV3 -966 6531
SCO1 1765 2221
SCO2 2396 237
SDHA -2650 6868
SDHB -1475 3928
SDHC -3136 4014
SURF1 -1424 4051
TACO1 -4362 1969
TMEM126B 2827 440
TMEM186 -536 2723
TRAP1 -1692 6777
UCP2 -1653 6416
UQCR11 -4398 8422
UQCRB -2279 1779
UQCRC1 -3414 5054
UQCRC2 -547 6364
UQCRFS1 -1151 5771
UQCRH -4335 652
UQCRQ -3077 4201



Respiratory electron transport

Respiratory electron transport
metric value
setSize 81
pMANOVA 1.72e-06
p.adjustMANOVA 4.56e-05
s.dist 0.329
s.RNA -0.327
s.meth -0.0402
p.RNA 3.93e-07
p.meth 0.532




Top 20 genes
Gene RNA meth
COX5B -3992 -244
NDUFAF5 -382 -133

Click HERE to show all gene set members

All member genes
RNA meth
COA1 2071 8256
COQ10A 467 7736
COQ10B 2636 5769
COX11 2934 3025
COX14 -3473 3855
COX16 3674 3560
COX19 3545 298
COX20 3562 3497
COX4I1 -3349 4535
COX5A -3813 3397
COX5B -3992 -244
COX6A1 -4298 1809
COX6B1 -2925 2356
COX6C -2174 2408
COX7A2L -489 5803
COX7C -3932 603
COX8A -4207 3949
CYC1 -3882 5829
CYCS 2102 2450
ECSIT -3238 6323
ETFA 2927 5795
ETFB -3171 3419
ETFDH 3116 7626
LRPPRC 1645 376
NDUFA10 -420 5793
NDUFA11 -2905 601
NDUFA12 -535 729
NDUFA13 -4479 5091
NDUFA2 -4444 3313
NDUFA3 -3482 7304
NDUFA4 -2791 2018
NDUFA5 3596 333
NDUFA6 -2212 4184
NDUFA7 -3515 2639
NDUFA8 -192 5072
NDUFA9 3168 7361
NDUFAB1 -2579 1043
NDUFAF1 2034 426
NDUFAF2 233 2075
NDUFAF3 -3892 1824
NDUFAF4 429 -161
NDUFAF5 -382 -133
NDUFAF6 3389 -482
NDUFB1 -4259 7880
NDUFB10 -4300 4926
NDUFB2 -4385 8398
NDUFB3 -1941 5110
NDUFB4 -2457 1638
NDUFB5 2482 3909
NDUFB7 -4010 4869
NDUFB9 -4179 4749
NDUFC1 -1837 2107
NDUFC2 -3896 5333
NDUFS1 229 -31
NDUFS2 -1914 57
NDUFS3 -3323 193
NDUFS4 128 6272
NDUFS5 -3876 5637
NDUFS6 -4343 6204
NDUFS7 -3319 5729
NDUFS8 -4040 102
NDUFV1 -3154 4359
NDUFV2 770 1025
NDUFV3 -966 6531
SCO1 1765 2221
SCO2 2396 237
SDHA -2650 6868
SDHB -1475 3928
SDHC -3136 4014
SURF1 -1424 4051
TACO1 -4362 1969
TMEM126B 2827 440
TMEM186 -536 2723
TRAP1 -1692 6777
UQCR11 -4398 8422
UQCRB -2279 1779
UQCRC1 -3414 5054
UQCRC2 -547 6364
UQCRFS1 -1151 5771
UQCRH -4335 652
UQCRQ -3077 4201



Interferon alpha/beta signaling

Interferon alpha/beta signaling
metric value
setSize 51
pMANOVA 2.21e-06
p.adjustMANOVA 5.72e-05
s.dist 0.417
s.RNA 0.41
s.meth -0.076
p.RNA 4.18e-07
p.meth 0.348




Top 20 genes
Gene RNA meth
ISG15 4605 -542
BST2 2756 -711
USP18 4758 -387
MX2 4729 -241
IFIT2 4740 -227
OAS1 4653 -193
ISG20 2841 -116
PTPN1 984 -296

Click HERE to show all gene set members

All member genes
RNA meth
ABCE1 3234 2902
ADAR 4395 5945
BST2 2756 -711
EGR1 -1081 7109
HLA-A -4258 2274
HLA-B -1024 513
HLA-C -217 6790
HLA-E -1278 3744
HLA-F -3700 -24
HLA-H -4103 7849
IFI35 4501 208
IFI6 4660 920
IFIT1 4760 25
IFIT2 4740 -227
IFIT3 4761 7117
IFIT5 4680 7258
IFITM1 2862 818
IFNAR1 2643 6059
IFNAR2 -1233 1950
IP6K2 590 7313
IRF1 3543 5454
IRF2 3242 5323
IRF3 -2216 2803
IRF4 3077 4603
IRF5 -2147 8203
IRF7 4284 6617
IRF9 4691 5128
ISG15 4605 -542
ISG20 2841 -116
JAK1 -2780 6986
KPNA1 2524 6172
KPNB1 3755 5921
MX1 4733 1151
MX2 4729 -241
OAS1 4653 -193
OAS2 4750 3133
OAS3 4705 5423
OASL 4677 6420
PSMB8 1469 1753
PTPN1 984 -296
PTPN11 404 3777
PTPN6 -353 2545
RNASEL 3920 3080
SAMHD1 3450 7360
SOCS1 -1415 5666
SOCS3 -4424 698
STAT1 4650 956
STAT2 4692 3486
TYK2 -1723 1909
USP18 4758 -387
XAF1 4768 4696



Cell Cycle

Cell Cycle
metric value
setSize 514
pMANOVA 2.38e-06
p.adjustMANOVA 6.02e-05
s.dist 0.134
s.RNA 0.133
s.meth -0.0195
p.RNA 4.03e-07
p.meth 0.456




Top 20 genes
Gene RNA meth
MIS18BP1 4072 -813
TUBGCP5 4727 -597
SMC1B 4235 -549
ORC3 4075 -537
NEDD1 4283 -233
RAD9B 3380 -278
CCND2 1483 -618
ANAPC10 2240 -306
PPP1CB 2999 -226
RNF168 1291 -440
GINS4 1662 -298
UBE2S 707 -550
TAOK1 1714 -212
NDC1 1276 -274
TK1 481 -581
CDK11A 1022 -211
SPDL1 526 -327
MAPRE1 528 -252
PSMB2 133 -505
CHMP3 314 -59

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
ABL1 -2249 5977
ACD -3409 3685
ACTR1A -3386 886
AHCTF1 1694 4249
AJUBA -71 -835
AKAP9 4474 2144
AKT1 -4078 4230
AKT2 -3887 3475
ALMS1 2161 1376
ANAPC1 -351 3351
ANAPC10 2240 -306
ANAPC11 -4328 7059
ANAPC15 -4465 2693
ANAPC16 -376 6873
ANAPC2 -2785 1387
ANAPC4 4302 1495
ANAPC5 1020 3142
ANAPC7 4469 869
ANKLE2 -73 1688
ANKRD28 -238 7506
ARPP19 1862 3109
ATM 1634 2443
ATR 3578 3477
ATRIP 2535 7937
AURKA 3129 3139
AURKB -1560 6999
B9D2 -3361 1375
BABAM1 -3489 8299
BANF1 -4022 4199
BARD1 2971 7159
BIRC5 3476 6260
BLM 1009 3920
BLZF1 4676 3144
BORA 4204 434
BRCA1 3184 943
BRCA2 4519 151
BRIP1 3528 5492
BTRC -2202 66
BUB1 3338 2187
BUB1B -342 1298
BUB3 3386 3862
CC2D1B -3574 1119
CCNA2 2525 6920
CCNB1 2771 903
CCNB2 1650 2521
CCND1 3127 3568
CCND2 1483 -618
CCND3 -3454 2914
CCNE1 4347 6755
CCNE2 144 5076
CCNH 4325 5990
CDC14A -591 7702
CDC16 2944 7052
CDC20 -660 5845
CDC23 3474 4397
CDC25A -1699 5081
CDC25B 1100 1268
CDC6 1526 155
CDC7 -44 1910
CDCA5 2099 5231
CDCA8 1880 4578
CDK1 3280 4292
CDK11A 1022 -211
CDK11B -1389 3378
CDK2 360 6577
CDK4 -3226 6700
CDK5RAP2 3412 2591
CDK6 3156 2094
CDK7 3900 3672
CDKN1A 205 7579
CDKN1B -296 1658
CDKN2A 746 4878
CDKN2C -3749 4213
CDKN2D -4528 5171
CDT1 -1770 2816
CENPA -41 4735
CENPE 4716 2619
CENPF 1672 3963
CENPH 1011 4643
CENPJ 3031 1976
CENPK 3295 2021
CENPL 1398 1951
CENPM 311 5307
CENPN 3187 816
CENPO -3651 1169
CENPP 1904 4875
CENPQ 4134 2988
CENPT -1807 6486
CENPU 4069 7227
CEP131 -2353 7043
CEP135 4541 1908
CEP152 4084 1496
CEP164 2557 5860
CEP192 3855 4425
CEP250 461 4877
CEP290 4649 7343
CEP41 79 7536
CEP63 3963 6456
CEP70 2293 6393
CEP76 4132 3388
CEP78 -455 7751
CHEK1 2050 3140
CHEK2 2304 2255
CHMP2A -3792 7013
CHMP2B 2766 5744
CHMP3 314 -59
CHMP4A 1988 1773
CHMP4B -4368 4124
CHMP6 -4415 1561
CHMP7 -84 6937
CHTF18 -3704 1046
CHTF8 -2848 4031
CKAP5 1850 2731
CKS1B 4094 751
CLASP1 -1376 3286
CLASP2 2090 2891
CLIP1 3574 5562
CLSPN 3711 2818
CNEP1R1 4042 4761
CNTRL 4546 6120
CSNK1D -3936 6586
CSNK1E -2264 7038
CSNK2A2 1126 3957
CSNK2B -1331 7503
CTC1 -1382 5242
CTDNEP1 -4486 -247
CUL1 4686 1579
DAXX 1297 3531
DBF4 4088 839
DCTN2 -4492 -467
DCTN3 -3524 4086
DHFR 1352 224
DIDO1 -1818 1952
DNA2 4101 1482
DSCC1 1067 2405
DSN1 4114 2710
DYNC1H1 -621 1172
DYNC1I2 -163 261
DYNC1LI1 2931 6081
DYNC1LI2 961 3137
DYNLL1 -1533 5391
DYNLL2 -2741 3308
DYRK1A -315 7765
E2F1 2805 1130
E2F2 61 3021
E2F3 2817 5634
E2F4 -3779 838
E2F5 1385 2528
E2F6 160 5818
EML4 1059 28
ENSA -4167 901
EP300 1012 3364
ESCO1 4312 4740
ESCO2 2536 1981
ESPL1 3471 4938
EXO1 975 4028
FBXL18 552 5498
FBXO5 4642 2393
FBXW11 -2068 8437
FEN1 -1067 5510
FKBPL 1738 4889
FOXM1 3330 128
FZR1 -1998 7430
GAR1 112 3773
GINS1 3185 2261
GINS3 2098 7805
GINS4 1662 -298
GMNN 2995 4368
GOLGA2 -1689 1717
GORASP1 -568 -452
GORASP2 384 684
GSK3B -648 3637
GTSE1 3397 8287
HAUS1 2740 4386
HAUS2 4268 6842
HAUS4 -2666 5428
HAUS5 2450 4471
HAUS6 2843 7288
HAUS8 2848 7348
HDAC1 -483 4910
HJURP 1873 6161
HMMR 816 3599
HSP90AA1 2910 4876
HSP90AB1 585 829
HSPA2 -2262 5784
HUS1 3496 3330
INCENP -2788 744
IST1 971 1933
ITGB3BP -125 6262
JAK2 4742 6248
KAT5 -1917 5607
KIF18A 2623 2117
KIF20A -5 -149
KIF23 2200 2575
KIF2A -2049 107
KIF2C 4218 5613
KNTC1 3722 7395
KPNB1 3755 5921
LBR 766 84
LCMT1 -1651 3223
LEMD2 -3038 5142
LEMD3 -887 5873
LIG1 -689 1862
LIN37 -213 5733
LIN52 3269 6009
LIN54 2729 3183
LIN9 2777 6299
LMNA -2829 -409
LMNB1 3532 4104
LPIN1 3147 5878
LPIN2 1791 5561
MAD1L1 -179 969
MAD2L1 3289 1189
MAPK1 -664 2770
MAPK3 -4544 -479
MAPRE1 528 -252
MAX -930 5533
MCM10 1820 6878
MCM2 -1553 5046
MCM3 -1073 2065
MCM4 1334 4341
MCM5 -2742 6723
MCM6 56 7215
MCM7 -603 2790
MCM8 3052 4782
MCPH1 2063 3225
MDC1 883 3873
MDM2 4685 1092
MDM4 3961 1115
MIS12 2431 8140
MIS18A 125 -34
MIS18BP1 4072 -813
MLH3 -2410 3420
MNAT1 1367 2609
MSH5 2497 3190
MZT2A -3975 8079
NBN 3430 1983
NCAPD2 798 2885
NCAPD3 -834 1252
NCAPG 2972 5112
NCAPG2 2426 6565
NCAPH 2727 6187
NCAPH2 -2641 1725
NDC1 1276 -274
NDC80 4183 2986
NDE1 1881 2562
NDEL1 875 6018
NEDD1 4283 -233
NEK2 3267 2451
NEK6 -3767 655
NEK7 2399 686
NEK9 -2040 7406
NHP2 -3603 6994
NIPBL 2551 4332
NME7 1007 8289
NOP10 -3556 2404
NSL1 2242 5635
NUDC -3688 1037
NUF2 1360 5100
NUMA1 -3338 3306
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
ODF2 -2592 5123
OIP5 2936 5646
OPTN 1723 3563
ORC2 3013 7800
ORC3 4075 -537
ORC4 3340 32
ORC5 3899 5400
ORC6 2020 2302
PAFAH1B1 -671 5606
PCBP4 34 7919
PCM1 3657 2291
PCNA 2634 4219
PCNT -2124 2386
PDS5A 2487 4720
PDS5B 1405 614
PHF20 -512 2909
PHLDA1 1928 5055
PIAS4 -2955 7610
PIF1 -178 51
PKMYT1 320 6273
PLK1 762 4665
PLK4 2153 2938
PMF1 -1872 2352
POLA2 3566 5083
POLD1 -2967 753
POLD2 -2505 408
POLD3 1236 1553
POLD4 -3381 4449
POLE 1079 5293
POLE2 4455 7989
POLE3 -3868 1562
POLE4 -3665 6198
POLR2A -851 -175
POLR2B 647 1497
POLR2C -2229 4506
POLR2D 2056 1352
POLR2E -4392 2995
POLR2F -4196 6542
POLR2G -4186 8051
POLR2H -3384 7582
POLR2I -4069 6360
POLR2K 3044 2463
POM121 -1366 5167
POM121C -3196 5663
PPME1 2565 977
PPP1CB 2999 -226
PPP1CC 3626 3213
PPP1R12A 3579 2879
PPP1R12B 2234 3491
PPP2CA -120 7715
PPP2CB 1948 15
PPP2R1B 2397 612
PPP2R2A 4703 545
PPP2R5A 2453 1231
PPP2R5B 339 7072
PPP2R5C 1399 5914
PPP2R5D -853 5740
PPP2R5E 2347 2424
PPP6C 3216 45
PPP6R3 3292 5905
PRIM1 3973 5416
PRIM2 1185 276
PRKACA -2849 3985
PRKCA -2013 8000
PRKCB -2116 4210
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC3IP 4438 3394
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PTTG1 1785 7447
RAB1A 818 4344
RAB1B -4317 2589
RAB2A 2474 2863
RAB8A 969 796
RAD1 2968 2840
RAD17 3132 2108
RAD21 967 2688
RAD50 4672 179
RAD51 3691 3959
RAD9A 1656 6474
RAD9B 3380 -278
RAE1 1852 710
RAN 136 2287
RANBP2 3105 4436
RANGAP1 -1846 6695
RB1 1147 1518
RBBP4 1636 2574
RBBP8 4599 1067
RBL1 1356 3163
RBL2 -3608 420
RBX1 776 6226
RCC1 -4524 6687
RCC2 771 3403
REC8 4322 342
RFC2 -2543 6031
RFC3 964 1603
RFC4 3063 4907
RFC5 1648 7821
RHNO1 -1091 8207
RMI2 4712 4668
RNF168 1291 -440
RNF8 3188 4447
RPA1 -1575 8080
RPA3 956 1331
RPS27A -4344 2492
RRM2 1604 5483
RSF1 3842 5286
RTEL1 -827 3440
RUVBL1 -666 6095
RUVBL2 -3857 7969
SDCCAG8 39 1961
SEC13 -2693 7357
SEH1L 3110 6644
SET 124 2256
SFN -287 -556
SHQ1 1142 4402
SIRT2 -4244 3540
SKA2 3554 3206
SKP1 2353 3193
SKP2 4608 3439
SMARCA5 3756 1328
SMC1B 4235 -549
SMC2 4339 1398
SMC3 3492 4966
SMC4 4586 3185
SPAST 2021 6893
SPC24 58 5476
SPDL1 526 -327
SRC -1513 -92
SSNA1 -4445 6709
STAG1 -467 2912
STAG3 2455 3275
SUMO1 2148 4431
SUN1 614 659
SUN2 -3961 4929
SYCE2 2724 2398
SYNE1 626 8106
SYNE2 1043 217
TAOK1 1714 -212
TEN1 -3619 8321
TERF1 2606 5033
TERF2 2089 5105
TERF2IP -1882 7036
TERT 4468 733
TFDP1 1708 471
TFDP2 -2800 3770
TINF2 -2823 4849
TK1 481 -581
TMPO 3307 6701
TNPO1 1488 4389
TOP2A 3421 4423
TOP3A 142 4401
TOPBP1 3085 7075
TP53 -92 1992
TP53BP1 1762 2668
TPR 3482 5135
TPX2 788 1461
TUBA1A -1025 1542
TUBA1B 1039 3597
TUBA1C 691 1968
TUBA4A -2917 7151
TUBA4B 2335 3513
TUBB -254 3715
TUBB2A 860 4091
TUBB4B -1808 6419
TUBG1 312 8221
TUBG2 -653 3395
TUBGCP2 -4137 7827
TUBGCP3 -490 8013
TUBGCP5 4727 -597
TUBGCP6 -826 3584
TYMS 2272 3871
UBA52 -4076 4404
UBB -3235 564
UBC -1858 2635
UBE2C -2854 1584
UBE2D1 273 4705
UBE2E1 -754 3149
UBE2I -1908 3654
UBE2N 2933 6764
UBE2S 707 -550
UBE2V2 3622 5531
UIMC1 -424 7598
USO1 3964 3166
VPS4A -4114 1747
VRK1 2800 2415
VRK2 4614 3132
WEE1 2694 480
WRAP53 -3357 1879
WRN 2314 7146
XPO1 4524 5628
YWHAB 3503 4090
YWHAE 431 6202
YWHAG -2995 5676
YWHAH 95 3469
YWHAQ -572 1317
YWHAZ 2452 2738
ZW10 3615 4456
ZWILCH 4303 4734
ZWINT 1153 906



Gene expression (Transcription)

Gene expression (Transcription)
metric value
setSize 1005
pMANOVA 2.74e-06
p.adjustMANOVA 6.81e-05
s.dist 0.0961
s.RNA 0.0927
s.meth 0.0252
p.RNA 1.51e-06
p.meth 0.192




Top 20 genes
Gene RNA meth
AGO3 4723 8331
MED31 4533 8039
ZNF566 4476 8047
MTERF1 4353 8235
PCGF5 4488 7908
ZNF483 4423 7883
MOV10 4456 7640
ZNF550 4275 7737
ZNF440 3996 8184
MSH2 4623 7030
PSME4 3989 7913
POLR3C 3883 8002
NUP54 4689 6539
ZNF791 4022 7609
TAF1D 4370 6983
SATB2 3673 8255
ZNF569 3965 7642
ZNF141 4062 7420
MED6 4248 7020
CCNE1 4347 6755

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
ABL1 -2249 5977
ACTB -2121 4265
ACTL6A 380 1199
AEBP2 454 8038
AFF4 1639 5828
AGO1 -3251 -803
AGO2 -210 556
AGO3 4723 8331
AKT1 -4078 4230
AKT2 -3887 3475
ALYREF -3965 3415
ANAPC1 -351 3351
ANAPC10 2240 -306
ANAPC11 -4328 7059
ANAPC15 -4465 2693
ANAPC16 -376 6873
ANAPC2 -2785 1387
ANAPC4 4302 1495
ANAPC5 1020 3142
ANAPC7 4469 869
ANG -4283 5360
APAF1 652 7539
ARID1A -742 8441
ARID1B -1584 5754
ARID2 1766 -62
ARID3A -1655 3794
ARID4B 3983 877
ASH2L 1973 5772
ATAD2 3957 -527
ATM 1634 2443
ATR 3578 3477
ATRIP 2535 7937
ATXN3 2958 2323
AURKA 3129 3139
AURKB -1560 6999
AUTS2 -1354 5798
AXIN1 -3846 6798
BANP -753 1180
BARD1 2971 7159
BAX -3208 -40
BAZ1B 1123 5241
BAZ2A 2969 3838
BBC3 -3282 3834
BCDIN3D 1040 2741
BCL2L11 -354 5324
BCL6 -921 980
BDP1 3484 7189
BID -1337 4237
BIRC5 3476 6260
BLM 1009 3920
BMI1 2392 4629
BNIP3L 1580 2966
BRCA1 3184 943
BRD1 -2563 7524
BRD2 1760 3438
BRD7 4388 3504
BRF1 -4096 3895
BRF2 -3939 7193
BRIP1 3528 5492
BRPF1 -3062 717
BRPF3 -622 4773
BTG1 -1189 1212
BTG2 -33 4615
CALM1 1471 3996
CAMK2D -1254 3808
CAMK2G -669 31
CAMK4 -1023 2737
CASC3 -981 3341
CASP1 3166 -381
CASP10 3024 1617
CASP6 441 1181
CAT -305 -221
CAV1 2411 7738
CBFB 2561 1473
CBX3 3611 997
CBX4 -2606 5617
CBX6 -3140 7540
CBX8 -1341 73
CCNA2 2525 6920
CCNB1 2771 903
CCNC 3746 2192
CCND1 3127 3568
CCND2 1483 -618
CCND3 -3454 2914
CCNE1 4347 6755
CCNE2 144 5076
CCNG1 1001 599
CCNG2 2209 3602
CCNH 4325 5990
CCNK 3396 2118
CCNT1 962 211
CDC16 2944 7052
CDC23 3474 4397
CDC40 2854 3353
CDC7 -44 1910
CDC73 2813 2294
CDK1 3280 4292
CDK12 1029 1546
CDK13 146 5488
CDK2 360 6577
CDK4 -3226 6700
CDK5 -312 4651
CDK5R1 -3377 7721
CDK6 3156 2094
CDK7 3900 3672
CDK8 2703 2327
CDK9 -4219 6663
CDKN1A 205 7579
CDKN1B -296 1658
CDKN2A 746 4878
CEBPB -1226 2587
CENPJ 3031 1976
CHD3 -3131 1467
CHD4 -1096 1893
CHEK1 2050 3140
CHEK2 2304 2255
CITED2 -2906 6665
CITED4 -3210 1832
CLP1 -1704 2956
CNOT1 1343 2760
CNOT10 3049 1988
CNOT11 3791 2648
CNOT3 -1162 3459
CNOT4 4571 2251
CNOT6 3552 6051
CNOT6L -162 4335
CNOT7 2184 6504
CNOT8 -1004 5201
COX11 2934 3025
COX14 -3473 3855
COX16 3674 3560
COX19 3545 298
COX20 3562 3497
COX4I1 -3349 4535
COX5A -3813 3397
COX5B -3992 -244
COX6A1 -4298 1809
COX6B1 -2925 2356
COX6C -2174 2408
COX7A2L -489 5803
COX7C -3932 603
COX8A -4207 3949
CPSF1 -1462 6607
CPSF2 1754 2298
CPSF3 929 -402
CPSF4 -3019 7194
CRADD -945 1883
CRCP 1721 6175
CREB1 2684 5066
CREBBP -2131 6830
CSNK2A2 1126 3957
CSNK2B -1331 7503
CSTF1 71 6895
CTDP1 -4073 1498
CTLA4 -2743 -762
CTNNB1 -867 6731
CTR9 1745 688
CTSL 3221 8394
CTSV -1526 7165
CUL1 4686 1579
CYCS 2102 2450
DAXX 1297 3531
DDB2 4522 -153
DDIT3 2404 1641
DDIT4 -4504 1795
DDX21 3407 7489
DEK 3735 4890
DGCR8 -1760 7035
DICER1 2781 8205
DNA2 4101 1482
DNMT1 -1875 3743
DNMT3A -1812 1532
DNMT3B -881 8042
DPY30 1463 5262
DYRK2 -1171 3889
E2F1 2805 1130
E2F4 -3779 838
E2F5 1385 2528
E2F6 160 5818
E2F7 3068 6535
E2F8 1487 3153
EAF1 1237 429
EED 3870 2932
EHMT1 -935 -506
EHMT2 -3090 5106
EIF4A3 -3458 5329
ELAC2 -2268 5479
ELF1 3223 3234
ELF2 3760 4641
ELL -2931 2306
ELL2 3847 4437
ELL3 4330 3574
EP300 1012 3364
EPC1 -999 887
ERBB2 -1613 7893
ERCC2 -1586 1785
ERCC3 1777 3558
ERCC6 -2371 6508
ESR2 1131 1955
ESRRA -3204 5928
EXO1 975 4028
EZH2 4487 4485
FANCC 1595 6181
FANCD2 775 8046
FANCI 3724 2277
FAS 4233 -122
FBXO32 -2542 6799
FBXW7 -370 6314
FIP1L1 812 2997
FKBP5 389 1867
FOS -3745 4083
FOXO1 -1206 821
FOXO3 -3182 7336
FYTTD1 2193 4195
FZR1 -1998 7430
GADD45A 343 65
GATA3 625 8175
GATAD2A -1612 7033
GATAD2B 2313 7362
GLS 4154 572
GPAM 2199 3283
GPI -3307 6596
GPS2 -1042 1242
GSK3B -648 3637
GSR -3081 1990
GTF2A1 2271 3947
GTF2A2 1864 4288
GTF2B 4279 1777
GTF2E2 2178 2527
GTF2F1 -3630 1349
GTF2F2 199 4275
GTF2H3 327 8269
GTF2H4 -2613 6171
GTF2H5 2768 1888
GTF3A -381 516
GTF3C1 -2271 4963
GTF3C2 -3582 5947
GTF3C3 2604 5781
GTF3C4 1579 8392
GTF3C5 -2570 5296
GTF3C6 1421 1131
HDAC1 -483 4910
HDAC10 -2446 6354
HDAC11 -2580 7767
HDAC2 357 4593
HDAC3 -2463 8308
HDAC4 -3000 1782
HDAC5 -3234 627
HDAC7 -2210 3814
HENMT1 -1020 4179
HEY2 -3753 -426
HIPK1 -1170 1972
HIPK2 -2350 5410
HIVEP3 3793 4998
HSP90AA1 2910 4876
HSPD1 744 1256
HUS1 3496 3330
ICE2 4413 728
IL2RA 2363 435
ING2 -1822 -145
ING5 -1920 6006
INTS1 -1396 26
INTS10 3309 2149
INTS12 4098 3916
INTS2 3284 858
INTS3 2937 3885
INTS4 2708 2106
INTS5 -3257 6817
INTS6 3067 1440
INTS7 4477 1931
INTS8 1659 6760
INTS9 -3387 2267
IPO8 3479 3748
ITCH 2437 6864
ITGA4 2309 4664
ITGA5 -4058 6926
ITGAL -224 4422
IWS1 3487 6768
JARID2 -2359 5886
JMY 1035 6992
JUN -2852 2775
JUNB -2929 4482
KAT2A -124 2984
KAT2B 4300 630
KAT5 -1917 5607
KCTD1 -626 5544
KCTD6 1295 7630
KMT2A 2145 -502
KMT2C 3111 8449
KMT2D 163 -326
KMT2E 4511 -599
KRAS 4256 4020
L3MBTL2 -3197 6563
LAMTOR1 -4490 -649
LAMTOR2 -4374 -288
LAMTOR3 3009 6767
LAMTOR4 -4140 1911
LAMTOR5 -3457 7083
LBR 766 84
LDB1 -3362 4806
LEO1 4657 5092
LMO2 -350 6069
LRPPRC 1645 376
LSM10 -1562 4339
LSM11 -3233 2782
MAF 870 3344
MAML1 -1344 5639
MAML2 -3917 2218
MAML3 -2225 8147
MAP2K6 2656 2172
MAPK1 -664 2770
MAPK14 -471 2235
MAPK3 -4544 -479
MAPKAP1 498 5528
MAX -930 5533
MBD2 1354 2865
MBD3 -3800 7276
MDC1 883 3873
MDM2 4685 1092
MDM4 3961 1115
MEAF6 1602 7082
MED1 884 5989
MED10 -687 437
MED13 -548 6657
MED15 -643 637
MED16 -3391 6781
MED17 2715 1178
MED20 -1924 3815
MED23 3644 2535
MED24 -2511 4354
MED25 -750 5856
MED26 -3998 4987
MED27 -707 2243
MED30 -1894 1820
MED31 4533 8039
MED4 2210 1156
MED6 4248 7020
MED7 4219 451
MED8 1107 5186
MEN1 -3356 2131
MGA 1994 1264
MLLT1 -4077 7004
MLLT3 2152 4894
MLST8 -2698 3421
MNAT1 1367 2609
MOV10 4456 7640
MSH2 4623 7030
MTA2 -1649 2515
MTA3 -873 857
MTERF1 4353 8235
MTF2 4392 2505
MTOR -2466 1240
MYB 2627 533
MYBBP1A -817 2000
MYBL1 2068 6157
NABP1 4510 5440
NABP2 -1617 3882
NBN 3430 1983
NCBP1 4364 6545
NCBP2 4238 3728
NCOR1 1467 1101
NCOR2 -3180 580
NDC1 1276 -274
NDRG1 -111 8120
NDUFA4 -2791 2018
NEDD4L -1595 223
NELFA -706 6889
NELFB -4311 5472
NELFCD -176 4159
NELFE -2330 8447
NFATC2 -119 5200
NFE2 -1918 3955
NFIA 3381 3073
NFIC -1215 -521
NFIX 451 2388
NFYA 47 2644
NFYB 2140 7873
NFYC -552 3129
NOP2 -3190 5056
NOTCH1 -2630 2429
NOTCH4 934 3925
NR1D1 -3155 5009
NR1D2 -106 5216
NR1H2 -3373 7088
NR1H3 -3834 8069
NR1I2 -2042 7321
NR2C1 3133 4128
NR2C2 -1123 -70
NR2C2AP 1956 3138
NR3C1 795 4250
NR3C2 -508 6632
NR4A1 2281 3392
NR4A2 -3632 6884
NR4A3 -1479 3356
NR6A1 -3321 -323
NRBP1 -4000 5899
NUDT21 2284 5050
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
PABPN1 -3354 7278
PAF1 -2593 8178
PAPOLA 2112 3899
PARP1 -684 377
PBRM1 2642 8122
PCBP4 34 7919
PCGF5 4488 7908
PCGF6 960 6092
PCNA 2634 4219
PDPK1 -2227 145
PHAX 1366 2478
PHC1 -3551 606
PHC2 -3417 4319
PHC3 3656 522
PHF1 161 2944
PHF19 296 2488
PHF20 -512 2909
PIDD1 -1306 3352
PIN1 -4273 3781
PINK1 -4013 4762
PIP4K2A -2400 5449
PIP4K2B -3175 1209
PIP4K2C 894 5957
PLAGL1 4305 3331
PLD6 -2346 2922
PLK2 -1310 8395
PLK3 -3084 2911
PMAIP1 3141 7628
PML 4203 1165
PMS2 2595 2725
POLDIP3 -838 1393
POLR1A -836 4125
POLR1B 2677 3210
POLR1C 925 2660
POLR1D -320 3948
POLR1E -2106 3992
POLR2A -851 -175
POLR2B 647 1497
POLR2C -2229 4506
POLR2D 2056 1352
POLR2E -4392 2995
POLR2F -4196 6542
POLR2G -4186 8051
POLR2H -3384 7582
POLR2I -4069 6360
POLR2K 3044 2463
POLR3A 2330 3852
POLR3C 3883 8002
POLR3D 149 182
POLR3E -3071 6454
POLR3F 2742 7929
POLR3G 1114 7045
POLR3GL -1161 233
POLR3H -3788 6332
POLR3K 1853 713
POLRMT -3460 1921
POM121 -1366 5167
POM121C -3196 5663
POU2F1 4535 5445
POU2F2 655 6067
PPARD -2714 4461
PPARGC1B 1069 -746
PPM1A 601 7691
PPM1D 2888 7828
PPP1R13B -875 1086
PPP1R13L -4427 5366
PPP2CA -120 7715
PPP2CB 1948 15
PPP2R1B 2397 612
PPP2R5C 1399 5914
PRDM1 -2048 4097
PRDX1 1389 4095
PRDX2 -2836 6462
PRDX5 -4506 7719
PRKAA1 2762 5633
PRKAB1 3846 3188
PRKAB2 395 4064
PRKACA -2849 3985
PRKAG1 1941 1531
PRKAG2 3104 5997
PRKCB -2116 4210
PRKCQ -36 3938
PRKRA 2773 2930
PRMT1 -3337 2070
PRMT5 255 1335
PRR5 -3441 4592
PSMA1 186 5226
PSMA2 -822 4948
PSMA3 4722 1439
PSMA5 1789 4192
PSMA6 3453 6164
PSMA7 -2427 5883
PSMB1 -2719 2993
PSMB10 -2938 694
PSMB2 133 -505
PSMB3 -2496 785
PSMB5 -4124 185
PSMB6 -4377 5658
PSMB7 -4334 1594
PSMB8 1469 1753
PSMB9 1178 3070
PSMC1 -762 2250
PSMC3 -3682 4698
PSMC4 -3258 1195
PSMC5 -3273 2046
PSMC6 3569 118
PSMD1 1749 5566
PSMD11 3107 2039
PSMD12 4558 5270
PSMD13 -3403 7835
PSMD14 1944 3912
PSMD2 -4346 6742
PSMD3 -4198 3075
PSMD4 -3692 1692
PSMD6 -155 3184
PSMD7 1088 871
PSMD8 -3382 7774
PSMD9 -4165 -186
PSME1 1282 7235
PSME2 3926 7233
PSME3 211 6561
PSME4 3989 7913
PSMF1 -2482 2268
PTEN 1170 3667
PTPN1 984 -296
PTPN11 404 3777
PTPN4 1197 1843
RABGGTA -249 2214
RABGGTB 2243 8182
RAD1 2968 2840
RAD17 3132 2108
RAD50 4672 179
RAD51 3691 3959
RAD51D 2013 8396
RAD9A 1656 6474
RAD9B 3380 -278
RAE1 1852 710
RAN 136 2287
RANBP2 3105 4436
RARA -2244 2140
RARG 497 3360
RB1 1147 1518
RBBP4 1636 2574
RBBP5 3016 5848
RBBP8 4599 1067
RBL1 1356 3163
RBL2 -3608 420
RBM14 -948 5300
RBPJ 1401 3986
RBX1 776 6226
RELA -3471 5749
RFC2 -2543 6031
RFC3 964 1603
RFC4 3063 4907
RFC5 1648 7821
RFFL -365 5184
RGCC -607 889
RHEB 2796 6691
RHNO1 -1091 8207
RICTOR 3910 4624
RING1 -3885 4529
RMI2 4712 4668
RNF111 2529 5568
RNF2 2490 7500
RNF34 3693 5306
RNGTT 3198 1738
RNMT 3661 2751
RNPS1 -1587 2194
RORA 524 7068
RPA1 -1575 8080
RPA3 956 1331
RPAP2 3523 6148
RPRD1A 2302 6237
RPRD2 1378 3694
RPS27A -4344 2492
RPTOR 308 -222
RRAGA -1598 8312
RRAGC 3286 7017
RRAGD -2441 3981
RRM2 1604 5483
RRM2B 3782 3044
RRN3 2457 6506
RTF1 2478 4114
RUNX1 4146 3270
RUNX2 316 5198
RUNX3 -1833 4830
RYBP 3313 812
SAP130 -373 6575
SAP18 -1992 6235
SAP30 -1829 5426
SAP30BP -732 3717
SAP30L -3018 5401
SATB2 3673 8255
SCMH1 -3339 7093
SCO1 1765 2221
SCO2 2396 237
SEC13 -2693 7357
SEH1L 3110 6644
SESN1 -776 4595
SESN2 -263 1608
SESN3 3988 3642
SETD1A -2735 874
SETD1B 1372 495
SETD9 -1852 2564
SFN -287 -556
SGK1 -3595 3687
SIN3A -798 1529
SIN3B -604 -271
SIRT1 2340 6815
SIRT3 -551 5347
SKI 559 2384
SKIL 4384 3965
SKP1 2353 3193
SKP2 4608 3439
SLBP 97 6846
SLC2A3 -2809 4149
SLC38A9 1899 6434
SLU7 3522 1810
SMAD1 2168 3549
SMAD2 2851 1116
SMAD3 13 5325
SMAD4 3942 777
SMAD6 2549 8107
SMAD7 -2766 4722
SMARCA2 -2067 7819
SMARCA4 -3042 2893
SMARCA5 3756 1328
SMARCB1 -527 5682
SMARCC1 336 8007
SMARCC2 355 3429
SMARCD1 897 1609
SMARCD2 -2908 6249
SMARCE1 -1152 5155
SMURF1 1336 199
SMURF2 673 4768
SMYD2 1104 8292
SNAPC1 2107 -42
SNAPC2 -2146 141
SNAPC3 4711 5441
SNAPC4 -1509 3174
SNAPC5 3560 3918
SNRPB -3973 7621
SNRPD3 -484 6820
SNRPE -1949 5874
SNRPG 1828 6488
SNW1 3124 3991
SOCS3 -4424 698
SOCS4 4627 2469
SOD2 1499 6344
SP1 -1581 2146
SPI1 -1412 3235
SRC -1513 -92
SREBF1 -2440 5382
SRRM1 4555 6158
SRRT -2251 849
SRSF11 1497 7857
SRSF2 -1228 3260
SRSF3 3555 187
SRSF4 103 -519
SRSF7 1837 4766
SRSF9 -3170 8085
SSB 4494 1736
SSRP1 -2405 2951
SSU72 748 2271
STAT1 4650 956
STK11 -3533 2662
STUB1 -4341 3494
SUDS3 2505 3071
SUMO1 2148 4431
SUPT16H 777 2239
SUPT4H1 -1880 7521
SUPT5H -2338 5377
SUPT6H -809 847
SURF1 -1424 4051
SYMPK 1433 3609
TACO1 -4362 1969
TAF10 -2924 2748
TAF11 4222 -261
TAF12 1194 486
TAF13 3766 3314
TAF15 -3822 7204
TAF1A 3201 7005
TAF1B 4588 -473
TAF1C -116 5496
TAF1D 4370 6983
TAF2 4458 1412
TAF3 3463 7268
TAF4 -51 5640
TAF4B 866 716
TAF5 2433 3006
TAF6 -1891 4411
TAF7 745 6649
TAF8 1490 5630
TAF9 3601 759
TARBP2 -3445 4476
TBL1XR1 1832 1367
TCEA1 2925 2742
TCF12 906 -80
TCF3 -605 3020
TCF7 -1961 7618
TCF7L2 4720 2013
TDG 3042 -715
TDRKH 613 6944
TET1 616 294
TET3 -1854 -731
TFAM -107 2592
TFAP2E -3991 8041
TFDP1 1708 471
TFDP2 -2800 3770
TGFA -2423 7668
TGFB1 -3735 4353
TGIF1 -3134 433
TGIF2 1396 2252
THOC1 3648 7153
THOC5 -177 4223
THOC7 3194 3742
THRA -2557 1759
TIGAR 4485 4300
TMEM219 -1886 3561
TNFRSF10A 2265 4930
TNFRSF10B -1543 4854
TNFRSF10D -2545 2606
TNKS1BP1 -2913 1210
TNRC6A 4363 6086
TNRC6B 2494 787
TOP3A 142 4401
TOPBP1 3085 7075
TP53 -92 1992
TP53BP2 1798 -432
TP53I3 270 6473
TP53INP1 1074 4774
TP53RK 1075 6091
TPR 3482 5135
TPX2 788 1461
TRIAP1 -115 3915
TRIM28 -4090 3417
TRIM33 4508 4302
TSC1 1768 6047
TSC2 -953 5090
TSN 2257 1077
TSNAX 3250 2647
TTC5 2473 2886
TTF1 3606 291
TXN -441 339
TXNIP 508 3975
TXNRD1 -917 214
U2AF1 2057 6524
U2AF1L4 958 -455
U2AF2 -4104 6409
UBA52 -4076 4404
UBB -3235 564
UBC -1858 2635
UBE2C -2854 1584
UBE2D1 273 4705
UBE2D3 1741 2455
UBE2E1 -754 3149
UBE2I -1908 3654
UBE2S 707 -550
UBTF -2772 623
UHRF1 2613 3738
USP7 -1838 1994
VDR 1410 2694
VEGFA -3785 832
WDR33 1934 7078
WDR5 -2102 4719
WDR61 1842 2444
WRN 2314 7146
WWOX -4055 81
WWP1 2765 4701
XPO5 1696 6289
YAF2 4713 -737
YEATS4 -368 3248
YES1 1814 -624
YWHAB 3503 4090
YWHAE 431 6202
YWHAG -2995 5676
YWHAH 95 3469
YWHAQ -572 1317
YWHAZ 2452 2738
YY1 -3924 2757
ZC3H8 3093 4017
ZFHX3 -236 8049
ZFP1 1532 817
ZFP14 3585 1135
ZFP28 -1831 8097
ZFP30 2574 3192
ZFP37 1660 8414
ZFP90 1955 508
ZFPM1 -4082 1208
ZIK1 -1464 -629
ZKSCAN1 3825 4601
ZKSCAN3 4323 834
ZKSCAN4 2421 4813
ZKSCAN5 973 3390
ZKSCAN8 2728 351
ZNF10 3729 5896
ZNF101 2521 4365
ZNF136 2052 7231
ZNF138 2673 1244
ZNF14 3897 2847
ZNF140 4060 5129
ZNF141 4062 7420
ZNF143 -849 993
ZNF155 -683 6082
ZNF160 4513 -534
ZNF169 2146 1000
ZNF17 -193 6351
ZNF175 3 2877
ZNF18 3457 685
ZNF180 1709 6794
ZNF184 1333 -507
ZNF189 1386 -343
ZNF19 2621 4010
ZNF2 1451 4555
ZNF20 3172 8033
ZNF200 3526 2022
ZNF202 4093 1792
ZNF211 1834 7515
ZNF212 -43 453
ZNF213 -3617 1341
ZNF215 4220 -726
ZNF221 2287 5266
ZNF222 -18 7777
ZNF223 -1404 7786
ZNF224 3310 4188
ZNF226 1661 5810
ZNF227 1965 348
ZNF23 2530 3472
ZNF233 1919 -851
ZNF234 1695 8004
ZNF235 406 1472
ZNF248 2734 43
ZNF25 3752 3548
ZNF250 -166 1882
ZNF253 1362 2943
ZNF257 1875 8023
ZNF26 3799 -830
ZNF264 2208 2787
ZNF268 4264 5522
ZNF274 512 5959
ZNF282 -3843 6908
ZNF286A -393 6973
ZNF287 76 4165
ZNF3 2084 2830
ZNF302 143 3974
ZNF311 2907 3115
ZNF324 -1844 6503
ZNF324B 1207 7972
ZNF331 -1898 1030
ZNF333 2774 1085
ZNF337 -406 1484
ZNF33A 3251 278
ZNF33B 1202 2207
ZNF34 -2274 2491
ZNF343 -1658 5599
ZNF354A 3445 4439
ZNF354C -310 7509
ZNF382 4015 3879
ZNF394 1152 42
ZNF398 -228 6982
ZNF417 -1333 7025
ZNF418 -980 7843
ZNF419 -884 4371
ZNF420 2900 1204
ZNF425 -922 7269
ZNF426 3993 4542
ZNF43 2425 6548
ZNF430 4499 5222
ZNF431 2687 5674
ZNF432 1995 2253
ZNF436 -1089 1979
ZNF440 3996 8184
ZNF443 1520 1591
ZNF445 3520 4343
ZNF446 -3232 4061
ZNF461 3995 1395
ZNF468 4504 -734
ZNF470 -2265 8015
ZNF480 936 8160
ZNF483 4423 7883
ZNF484 3761 5335
ZNF490 3478 7864
ZNF492 2625 8128
ZNF496 -606 6860
ZNF500 -1884 7196
ZNF506 4694 883
ZNF517 -984 5093
ZNF528 2795 2759
ZNF529 3840 7167
ZNF530 2104 8305
ZNF540 2331 6633
ZNF546 3851 5998
ZNF547 3448 5452
ZNF549 1021 6606
ZNF550 4275 7737
ZNF552 67 5689
ZNF554 309 3762
ZNF559 -1083 4293
ZNF561 3368 8236
ZNF563 3369 8357
ZNF564 3803 5435
ZNF566 4476 8047
ZNF567 4126 4748
ZNF568 579 -428
ZNF569 3965 7642
ZNF570 4502 3371
ZNF571 3102 4178
ZNF573 2564 778
ZNF582 3149 1329
ZNF583 -61 2390
ZNF584 -1181 5859
ZNF585A 4701 5742
ZNF585B 3564 4826
ZNF587 2135 8263
ZNF589 3506 3556
ZNF596 386 1013
ZNF597 3321 -434
ZNF600 1369 2531
ZNF605 1426 1036
ZNF606 -797 8405
ZNF610 235 6153
ZNF611 3270 4186
ZNF613 4200 4757
ZNF614 3325 4909
ZNF615 1363 4689
ZNF619 2410 3718
ZNF620 3215 3346
ZNF621 4061 7021
ZNF624 950 4071
ZNF627 -1122 7034
ZNF641 1900 5847
ZNF655 2182 3989
ZNF664 676 4142
ZNF665 3260 7090
ZNF668 -4216 4234
ZNF670 1787 1410
ZNF671 -824 7537
ZNF677 -30 7569
ZNF678 600 1999
ZNF681 1453 6039
ZNF684 4110 1614
ZNF688 -3649 4320
ZNF689 -1383 6455
ZNF691 2819 4056
ZNF692 -1512 5229
ZNF696 -2673 3310
ZNF70 778 5244
ZNF700 2941 6362
ZNF701 3409 4232
ZNF703 685 5514
ZNF706 2581 2973
ZNF707 -520 4704
ZNF708 2912 3605
ZNF709 917 2397
ZNF710 -2568 7942
ZNF713 4602 -592
ZNF714 2681 4609
ZNF717 3497 -445
ZNF736 2946 7994
ZNF737 3632 4415
ZNF74 -3854 2596
ZNF740 -686 7341
ZNF746 -1160 2211
ZNF747 -4128 5967
ZNF749 617 -805
ZNF75A 1827 8386
ZNF761 -319 806
ZNF764 -2409 6130
ZNF77 2989 -682
ZNF771 169 1722
ZNF772 -1056 7166
ZNF774 3410 7409
ZNF775 -4384 4857
ZNF776 -383 801
ZNF777 -3114 3239
ZNF778 -1682 6623
ZNF782 414 1226
ZNF785 -1578 6379
ZNF786 -95 2115
ZNF79 1437 7316
ZNF790 3206 8017
ZNF791 4022 7609
ZNF792 -2875 63
ZNF793 1981 6756
ZNF799 3032 8108
ZNF839 -404 3046
ZNF92 3878 5361
ZSCAN25 -2357 -849



Antiviral mechanism by IFN-stimulated genes

Antiviral mechanism by IFN-stimulated genes
metric value
setSize 77
pMANOVA 4.23e-06
p.adjustMANOVA 0.000103
s.dist 0.333
s.RNA 0.321
s.meth -0.0867
p.RNA 1.16e-06
p.meth 0.189




Top 20 genes
Gene RNA meth
EIF4E3 4068 -728
ISG15 4605 -542
PDE12 3865 -503
USP18 4758 -387
MX2 4729 -241
OAS1 4653 -193
PPM1B 3027 -194
NDC1 1276 -274

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -951 2730
ABCE1 3234 2902
ARIH1 2852 5841
DDX58 4744 2919
EIF2AK2 4762 189
EIF4A1 -2281 5352
EIF4A2 3092 5327
EIF4A3 -3458 5329
EIF4E 3927 5614
EIF4E2 -2507 2810
EIF4E3 4068 -728
EIF4G1 -3207 3220
EIF4G2 1388 6231
EIF4G3 1078 900
FLNB 392 3896
HERC5 4748 1229
IFIT1 4760 25
IRF3 -2216 2803
ISG15 4605 -542
JAK1 -2780 6986
KPNA1 2524 6172
KPNA2 2087 843
KPNA3 3432 1404
KPNA4 3745 8152
KPNA5 4407 1689
KPNB1 3755 5921
MAPK3 -4544 -479
MX1 4733 1151
MX2 4729 -241
NDC1 1276 -274
NEDD4 1887 6220
NUP107 3990 1024
NUP133 1781 1480
NUP153 1977 7289
NUP155 3012 5103
NUP160 2980 5801
NUP188 -1361 596
NUP205 1045 373
NUP210 -1780 780
NUP214 -156 7349
NUP35 1329 7594
NUP37 612 503
NUP43 4431 140
NUP50 3019 5792
NUP54 4689 6539
NUP62 -1972 2715
NUP85 1224 5415
NUP88 2360 6451
NUP93 2610 7878
NUP98 1161 1656
OAS1 4653 -193
OAS2 4750 3133
OAS3 4705 5423
OASL 4677 6420
PDE12 3865 -503
PIN1 -4273 3781
PLCG1 345 5809
POM121 -1366 5167
POM121C -3196 5663
PPM1B 3027 -194
RAE1 1852 710
RANBP2 3105 4436
RNASEL 3920 3080
RPS27A -4344 2492
SEC13 -2693 7357
SEH1L 3110 6644
STAT1 4650 956
TPR 3482 5135
TRIM25 3559 6656
UBA52 -4076 4404
UBA7 1772 3041
UBB -3235 564
UBC -1858 2635
UBE2E1 -754 3149
UBE2L6 4162 765
UBE2N 2933 6764
USP18 4758 -387



Glycosaminoglycan metabolism

Glycosaminoglycan metabolism
metric value
setSize 61
pMANOVA 5.48e-06
p.adjustMANOVA 0.00013
s.dist 0.373
s.RNA -0.333
s.meth 0.168
p.RNA 7.23e-06
p.meth 0.0235




Top 20 genes
Gene RNA meth
B3GNT7 -4107 7920
NAGLU -3759 7426
UST -4351 6034
B3GALT6 -3557 7118
B4GALT1 -2892 7957
HEXA -3270 6940
IDUA -2710 7884
B3GAT3 -3620 5844
CHPF2 -3681 5473
CHST2 -3908 4950
XYLT1 -3919 4457
GUSB -2990 4887
HS3ST3B1 -1727 8081
GLB1 -1934 7211
ST3GAL1 -2314 5875
CHST14 -2833 4687
CD44 -2857 4410
B4GALT6 -2272 5500
ABCC5 -2923 4067
GLCE -1910 6213

Click HERE to show all gene set members

All member genes
RNA meth
ABCC5 -2923 4067
AGRN 3879 3516
ARSB 809 6874
B3GALT6 -3557 7118
B3GAT2 -409 7818
B3GAT3 -3620 5844
B3GNT2 3985 6205
B3GNT7 -4107 7920
B4GALT1 -2892 7957
B4GALT2 298 -162
B4GALT3 1504 2276
B4GALT4 271 4038
B4GALT5 209 5443
B4GALT6 -2272 5500
B4GALT7 -1253 5460
B4GAT1 -3374 805
CD44 -2857 4410
CHP1 -2763 624
CHPF -533 5678
CHPF2 -3681 5473
CHST11 -3315 2817
CHST12 1583 6327
CHST14 -2833 4687
CHST2 -3908 4950
CHSY1 -438 1619
CSGALNACT1 -1621 1521
CSGALNACT2 3709 323
DSE -2674 3771
DSEL 932 6534
EXT1 -504 7581
EXT2 -1332 7940
GLB1 -1934 7211
GLCE -1910 6213
GNS -638 5474
GPC2 -1960 5692
GUSB -2990 4887
HEXA -3270 6940
HEXB -1501 7586
HMMR 816 3599
HS3ST3B1 -1727 8081
HS6ST1 -2841 1462
HYAL1 3808 -580
HYAL2 -3972 2095
HYAL3 -1535 3787
IDUA -2710 7884
NAGLU -3759 7426
NDST2 -2442 -263
PAPSS1 446 6222
SDC4 -3045 2476
SLC26A2 323 7114
SLC35B2 -3696 3060
SLC35B3 2593 875
SLC9A1 -2736 996
ST3GAL1 -2314 5875
ST3GAL2 -2611 2056
ST3GAL3 -1465 3508
ST3GAL4 -3567 2599
ST3GAL6 1909 8424
UST -4351 6034
XYLT1 -3919 4457
XYLT2 -2551 2519



Homologous DNA Pairing and Strand Exchange

Homologous DNA Pairing and Strand Exchange
metric value
setSize 38
pMANOVA 1.45e-05
p.adjustMANOVA 0.000338
s.dist 0.438
s.RNA 0.433
s.meth 0.069
p.RNA 3.92e-06
p.meth 0.463




Top 20 genes
Gene RNA meth
RMI2 4712 4668
TOPBP1 3085 7075
BARD1 2971 7159
ATRIP 2535 7937
BRIP1 3528 5492
RAD51D 2013 8396
RAD51AP1 3960 4236
WRN 2314 7146
RFC4 3063 4907
RAD51 3691 3959
PALB2 2204 6184
RFC5 1648 7821
ATR 3578 3477
HUS1 3496 3330
RAD9A 1656 6474
RAD1 2968 2840
NBN 3430 1983
RAD17 3132 2108
CHEK1 2050 3140
DNA2 4101 1482

Click HERE to show all gene set members

All member genes
RNA meth
ATM 1634 2443
ATR 3578 3477
ATRIP 2535 7937
BARD1 2971 7159
BLM 1009 3920
BRCA1 3184 943
BRCA2 4519 151
BRIP1 3528 5492
CHEK1 2050 3140
DNA2 4101 1482
EXO1 975 4028
HUS1 3496 3330
KAT5 -1917 5607
NBN 3430 1983
PALB2 2204 6184
RAD1 2968 2840
RAD17 3132 2108
RAD50 4672 179
RAD51 3691 3959
RAD51AP1 3960 4236
RAD51B 4484 515
RAD51D 2013 8396
RAD9A 1656 6474
RAD9B 3380 -278
RBBP8 4599 1067
RFC2 -2543 6031
RFC3 964 1603
RFC4 3063 4907
RFC5 1648 7821
RHNO1 -1091 8207
RMI2 4712 4668
RPA1 -1575 8080
RPA3 956 1331
TOP3A 142 4401
TOPBP1 3085 7075
WRN 2314 7146
XRCC2 -50 327
XRCC3 -2932 7813



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.0   GGally_2.1.1    ggplot2_3.3.3   reshape2_1.4.4 
##  [5] beeswarm_0.3.1  gplots_3.1.1    gtools_3.8.2    tibble_3.1.0   
##  [9] dplyr_1.0.5     echarts4r_0.4.0 mitch_1.2.2    
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.6         rprojroot_2.0.2    assertthat_0.2.1   digest_0.6.27     
##  [5] utf8_1.2.1         mime_0.10          R6_2.5.0           plyr_1.8.6        
##  [9] evaluate_0.14      highr_0.8          pillar_1.5.1       rlang_0.4.10      
## [13] jquerylib_0.1.3    rmarkdown_2.7      labeling_0.4.2     desc_1.3.0        
## [17] stringr_1.4.0      htmlwidgets_1.5.3  munsell_0.5.0      shiny_1.6.0       
## [21] compiler_4.0.3     httpuv_1.5.5       xfun_0.22          pkgconfig_2.0.3   
## [25] htmltools_0.5.1.1  tidyselect_1.1.0   gridExtra_2.3      reshape_0.8.8     
## [29] fansi_0.4.2        crayon_1.4.1       withr_2.4.1        later_1.1.0.1     
## [33] MASS_7.3-53.1      bitops_1.0-6       grid_4.0.3         jsonlite_1.7.2    
## [37] xtable_1.8-4       gtable_0.3.0       lifecycle_1.0.0    DBI_1.1.1         
## [41] magrittr_2.0.1     scales_1.1.1       KernSmooth_2.23-18 stringi_1.5.3     
## [45] farver_2.1.0       promises_1.2.0.1   testthat_3.0.2     bslib_0.2.4       
## [49] ellipsis_0.3.1     generics_0.1.0     vctrs_0.3.6        RColorBrewer_1.1-2
## [53] tools_4.0.3        glue_1.4.2         purrr_0.3.4        parallel_4.0.3    
## [57] fastmap_1.1.0      yaml_2.2.1         colorspace_2.0-0   caTools_1.18.1    
## [61] knitr_1.31         sass_0.3.1

END of report