date generated: 2020-08-19

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##              RNA        meth
## A1BG  -0.2700849 0.100632259
## AAAS  -1.3836098 0.230035602
## AACS  -0.3700472 0.682403328
## AAGAB  1.4820262 0.001540913
## AAK1  -1.0782919 0.360863030
## AAMDC  0.4638045 0.383673218

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 9286
duplicated_genes_present 0
num_profile_genes_in_sets 5525
num_profile_genes_not_in_sets 3761
profile_pearson_correl -0.10039
profile_spearman_correl -0.07335

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2400
num_genesets_excluded 1281
num_genesets_included 1119

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 443

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.RNA s.meth p.RNA p.meth
Neutrophil degranulation 306 1.49e-50 1.66e-47 0.509 0.505 -0.065700 1.13e-51 5.03e-02
Innate Immune System 617 2.85e-45 1.59e-42 0.342 0.342 -0.000106 2.74e-46 9.96e-01
Immune System 1197 2.34e-36 8.73e-34 0.225 0.223 0.032000 6.19e-36 7.36e-02
rRNA processing 159 3.55e-31 9.92e-29 0.552 -0.538 0.123000 1.26e-31 7.86e-03
rRNA processing in the nucleus and cytosol 154 2.70e-30 6.05e-28 0.554 -0.537 0.133000 1.41e-30 4.59e-03
Major pathway of rRNA processing in the nucleolus and cytosol 147 3.99e-30 7.44e-28 0.565 -0.548 0.135000 1.97e-30 5.05e-03
Signal Transduction 1169 6.63e-25 1.06e-22 0.186 0.177 0.056000 8.88e-23 1.92e-03
Membrane Trafficking 436 1.15e-23 1.60e-21 0.290 0.290 -0.002330 1.10e-24 9.34e-01
Vesicle-mediated transport 442 2.47e-23 3.07e-21 0.285 0.285 0.004040 2.85e-24 8.86e-01
Eukaryotic Translation Elongation 70 2.86e-22 3.20e-20 0.701 -0.670 0.205000 3.06e-22 3.05e-03
Peptide chain elongation 67 3.30e-21 3.35e-19 0.699 -0.667 0.208000 3.57e-21 3.29e-03
Formation of a pool of free 40S subunits 76 1.03e-20 9.59e-19 0.648 -0.622 0.182000 7.29e-21 6.22e-03
Influenza Viral RNA Transcription and Replication 110 2.06e-20 1.78e-18 0.539 -0.495 0.215000 3.54e-19 1.04e-04
Metabolism of RNA 535 6.33e-20 5.06e-18 0.247 -0.228 0.096400 7.31e-19 1.77e-04
Selenocysteine synthesis 68 7.85e-20 5.86e-18 0.669 -0.643 0.184000 4.60e-20 8.84e-03
Viral mRNA Translation 67 1.49e-19 1.04e-17 0.671 -0.634 0.220000 2.73e-19 1.90e-03
Eukaryotic Translation Termination 70 7.10e-19 4.67e-17 0.642 -0.622 0.158000 2.37e-19 2.25e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 86 2.89e-18 1.80e-16 0.573 -0.539 0.195000 6.13e-18 1.78e-03
L13a-mediated translational silencing of Ceruloplasmin expression 85 3.11e-18 1.83e-16 0.576 -0.543 0.190000 5.15e-18 2.47e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 72 3.41e-18 1.91e-16 0.624 -0.589 0.206000 5.47e-18 2.59e-03
Cap-dependent Translation Initiation 93 3.44e-17 1.75e-15 0.535 -0.499 0.193000 1.00e-16 1.33e-03
Eukaryotic Translation Initiation 93 3.44e-17 1.75e-15 0.535 -0.499 0.193000 1.00e-16 1.33e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 76 4.25e-17 2.02e-15 0.587 -0.562 0.167000 2.42e-17 1.20e-02
Influenza Infection 128 4.34e-17 2.02e-15 0.458 -0.408 0.207000 1.73e-15 5.65e-05
Selenoamino acid metabolism 76 7.45e-17 3.33e-15 0.582 -0.558 0.166000 4.19e-17 1.25e-02
Translation 234 1.06e-16 4.57e-15 0.330 -0.326 0.047200 1.18e-17 2.17e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 86 1.51e-15 6.03e-14 0.529 -0.483 0.215000 9.97e-15 5.80e-04
Nonsense-Mediated Decay (NMD) 86 1.51e-15 6.03e-14 0.529 -0.483 0.215000 9.97e-15 5.80e-04
SRP-dependent cotranslational protein targeting to membrane 85 7.97e-15 3.08e-13 0.519 -0.477 0.205000 3.29e-14 1.13e-03
Signaling by Receptor Tyrosine Kinases 284 8.99e-15 3.35e-13 0.276 0.274 0.032900 2.90e-15 3.44e-01
Hemostasis 303 1.38e-13 4.97e-12 0.259 0.259 -0.012300 1.43e-14 7.15e-01
Signaling by Interleukins 262 1.36e-12 4.76e-11 0.259 0.233 0.114000 1.20e-10 1.69e-03
Metabolism of lipids 427 3.37e-12 1.14e-10 0.210 0.206 -0.037200 4.92e-13 1.94e-01
Platelet activation, signaling and aggregation 133 4.94e-12 1.63e-10 0.358 0.351 0.067900 3.17e-12 1.78e-01
Gene expression (Transcription) 1004 1.07e-11 3.44e-10 0.141 -0.118 0.078500 1.02e-09 4.73e-05
Diseases of signal transduction by growth factor receptors and second messengers 259 7.74e-11 2.41e-09 0.243 0.234 0.065500 1.27e-10 7.18e-02
Signaling by WNT 174 1.15e-09 3.49e-08 0.273 0.192 0.194000 1.43e-05 1.14e-05
tRNA processing 93 1.23e-09 3.62e-08 0.390 -0.381 0.082400 2.28e-10 1.71e-01
rRNA modification in the nucleus and cytosol 47 1.56e-09 4.47e-08 0.545 -0.531 0.123000 3.19e-10 1.44e-01
Signaling by NOTCH 129 1.84e-09 5.16e-08 0.313 0.258 0.178000 4.77e-07 5.18e-04
Disease 870 5.73e-09 1.56e-07 0.122 0.107 0.059400 1.88e-07 3.84e-03
Leishmania infection 109 1.09e-08 2.89e-07 0.337 0.336 -0.015600 1.42e-09 7.80e-01
Formation of the ternary complex, and subsequently, the 43S complex 40 1.11e-08 2.89e-07 0.564 -0.536 0.175000 4.43e-09 5.64e-02
Regulation of expression of SLITs and ROBOs 122 1.28e-08 3.21e-07 0.328 -0.263 0.195000 5.58e-07 2.03e-04
Post-translational protein modification 887 1.29e-08 3.21e-07 0.120 0.115 0.035500 1.84e-08 8.17e-02
EPH-Ephrin signaling 54 2.20e-08 5.35e-07 0.465 0.465 0.015600 3.54e-09 8.43e-01
Cytokine Signaling in Immune system 496 2.31e-08 5.50e-07 0.153 0.129 0.081100 1.24e-06 2.33e-03
PIP3 activates AKT signaling 179 3.54e-08 8.25e-07 0.246 0.187 0.160000 1.81e-05 2.50e-04
Transport of small molecules 342 4.64e-08 1.06e-06 0.186 0.184 -0.027000 6.79e-09 3.96e-01
Generic Transcription Pathway 800 5.55e-08 1.24e-06 0.127 -0.109 0.065200 3.10e-07 2.27e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.RNA s.meth p.RNA p.meth
Neutrophil degranulation 306 1.49e-50 1.66e-47 0.50900 0.505000 -0.065700 1.13e-51 5.03e-02
Innate Immune System 617 2.85e-45 1.59e-42 0.34200 0.342000 -0.000106 2.74e-46 9.96e-01
Immune System 1197 2.34e-36 8.73e-34 0.22500 0.223000 0.032000 6.19e-36 7.36e-02
rRNA processing 159 3.55e-31 9.92e-29 0.55200 -0.538000 0.123000 1.26e-31 7.86e-03
rRNA processing in the nucleus and cytosol 154 2.70e-30 6.05e-28 0.55400 -0.537000 0.133000 1.41e-30 4.59e-03
Major pathway of rRNA processing in the nucleolus and cytosol 147 3.99e-30 7.44e-28 0.56500 -0.548000 0.135000 1.97e-30 5.05e-03
Signal Transduction 1169 6.63e-25 1.06e-22 0.18600 0.177000 0.056000 8.88e-23 1.92e-03
Membrane Trafficking 436 1.15e-23 1.60e-21 0.29000 0.290000 -0.002330 1.10e-24 9.34e-01
Vesicle-mediated transport 442 2.47e-23 3.07e-21 0.28500 0.285000 0.004040 2.85e-24 8.86e-01
Eukaryotic Translation Elongation 70 2.86e-22 3.20e-20 0.70100 -0.670000 0.205000 3.06e-22 3.05e-03
Peptide chain elongation 67 3.30e-21 3.35e-19 0.69900 -0.667000 0.208000 3.57e-21 3.29e-03
Formation of a pool of free 40S subunits 76 1.03e-20 9.59e-19 0.64800 -0.622000 0.182000 7.29e-21 6.22e-03
Influenza Viral RNA Transcription and Replication 110 2.06e-20 1.78e-18 0.53900 -0.495000 0.215000 3.54e-19 1.04e-04
Metabolism of RNA 535 6.33e-20 5.06e-18 0.24700 -0.228000 0.096400 7.31e-19 1.77e-04
Selenocysteine synthesis 68 7.85e-20 5.86e-18 0.66900 -0.643000 0.184000 4.60e-20 8.84e-03
Viral mRNA Translation 67 1.49e-19 1.04e-17 0.67100 -0.634000 0.220000 2.73e-19 1.90e-03
Eukaryotic Translation Termination 70 7.10e-19 4.67e-17 0.64200 -0.622000 0.158000 2.37e-19 2.25e-02
GTP hydrolysis and joining of the 60S ribosomal subunit 86 2.89e-18 1.80e-16 0.57300 -0.539000 0.195000 6.13e-18 1.78e-03
L13a-mediated translational silencing of Ceruloplasmin expression 85 3.11e-18 1.83e-16 0.57600 -0.543000 0.190000 5.15e-18 2.47e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 72 3.41e-18 1.91e-16 0.62400 -0.589000 0.206000 5.47e-18 2.59e-03
Cap-dependent Translation Initiation 93 3.44e-17 1.75e-15 0.53500 -0.499000 0.193000 1.00e-16 1.33e-03
Eukaryotic Translation Initiation 93 3.44e-17 1.75e-15 0.53500 -0.499000 0.193000 1.00e-16 1.33e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 76 4.25e-17 2.02e-15 0.58700 -0.562000 0.167000 2.42e-17 1.20e-02
Influenza Infection 128 4.34e-17 2.02e-15 0.45800 -0.408000 0.207000 1.73e-15 5.65e-05
Selenoamino acid metabolism 76 7.45e-17 3.33e-15 0.58200 -0.558000 0.166000 4.19e-17 1.25e-02
Translation 234 1.06e-16 4.57e-15 0.33000 -0.326000 0.047200 1.18e-17 2.17e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 86 1.51e-15 6.03e-14 0.52900 -0.483000 0.215000 9.97e-15 5.80e-04
Nonsense-Mediated Decay (NMD) 86 1.51e-15 6.03e-14 0.52900 -0.483000 0.215000 9.97e-15 5.80e-04
SRP-dependent cotranslational protein targeting to membrane 85 7.97e-15 3.08e-13 0.51900 -0.477000 0.205000 3.29e-14 1.13e-03
Signaling by Receptor Tyrosine Kinases 284 8.99e-15 3.35e-13 0.27600 0.274000 0.032900 2.90e-15 3.44e-01
Hemostasis 303 1.38e-13 4.97e-12 0.25900 0.259000 -0.012300 1.43e-14 7.15e-01
Signaling by Interleukins 262 1.36e-12 4.76e-11 0.25900 0.233000 0.114000 1.20e-10 1.69e-03
Metabolism of lipids 427 3.37e-12 1.14e-10 0.21000 0.206000 -0.037200 4.92e-13 1.94e-01
Platelet activation, signaling and aggregation 133 4.94e-12 1.63e-10 0.35800 0.351000 0.067900 3.17e-12 1.78e-01
Gene expression (Transcription) 1004 1.07e-11 3.44e-10 0.14100 -0.118000 0.078500 1.02e-09 4.73e-05
Diseases of signal transduction by growth factor receptors and second messengers 259 7.74e-11 2.41e-09 0.24300 0.234000 0.065500 1.27e-10 7.18e-02
Signaling by WNT 174 1.15e-09 3.49e-08 0.27300 0.192000 0.194000 1.43e-05 1.14e-05
tRNA processing 93 1.23e-09 3.62e-08 0.39000 -0.381000 0.082400 2.28e-10 1.71e-01
rRNA modification in the nucleus and cytosol 47 1.56e-09 4.47e-08 0.54500 -0.531000 0.123000 3.19e-10 1.44e-01
Signaling by NOTCH 129 1.84e-09 5.16e-08 0.31300 0.258000 0.178000 4.77e-07 5.18e-04
Disease 870 5.73e-09 1.56e-07 0.12200 0.107000 0.059400 1.88e-07 3.84e-03
Leishmania infection 109 1.09e-08 2.89e-07 0.33700 0.336000 -0.015600 1.42e-09 7.80e-01
Formation of the ternary complex, and subsequently, the 43S complex 40 1.11e-08 2.89e-07 0.56400 -0.536000 0.175000 4.43e-09 5.64e-02
Regulation of expression of SLITs and ROBOs 122 1.28e-08 3.21e-07 0.32800 -0.263000 0.195000 5.58e-07 2.03e-04
Post-translational protein modification 887 1.29e-08 3.21e-07 0.12000 0.115000 0.035500 1.84e-08 8.17e-02
EPH-Ephrin signaling 54 2.20e-08 5.35e-07 0.46500 0.465000 0.015600 3.54e-09 8.43e-01
Cytokine Signaling in Immune system 496 2.31e-08 5.50e-07 0.15300 0.129000 0.081100 1.24e-06 2.33e-03
PIP3 activates AKT signaling 179 3.54e-08 8.25e-07 0.24600 0.187000 0.160000 1.81e-05 2.50e-04
Transport of small molecules 342 4.64e-08 1.06e-06 0.18600 0.184000 -0.027000 6.79e-09 3.96e-01
Generic Transcription Pathway 800 5.55e-08 1.24e-06 0.12700 -0.109000 0.065200 3.10e-07 2.27e-03
Regulation of actin dynamics for phagocytic cup formation 45 6.81e-08 1.49e-06 0.49400 0.494000 0.000281 1.01e-08 9.97e-01
Clathrin-mediated endocytosis 90 8.87e-08 1.91e-06 0.34400 0.340000 0.051100 2.69e-08 4.04e-01
Intracellular signaling by second messengers 204 1.14e-07 2.40e-06 0.22300 0.181000 0.129000 9.05e-06 1.55e-03
MHC class II antigen presentation 70 1.17e-07 2.42e-06 0.39300 0.391000 -0.034000 1.60e-08 6.24e-01
ER to Golgi Anterograde Transport 105 1.27e-07 2.59e-06 0.32300 0.316000 -0.066800 2.38e-08 2.38e-01
Signaling by NTRKs 90 1.44e-07 2.88e-06 0.33600 0.325000 0.086800 1.09e-07 1.56e-01
RNA Polymerase II Transcription 892 1.87e-07 3.66e-06 0.11700 -0.095000 0.068100 2.91e-06 8.04e-04
Metabolism 1214 1.90e-07 3.66e-06 0.09950 0.098600 -0.013200 2.80e-08 4.57e-01
Translation initiation complex formation 47 3.12e-07 5.92e-06 0.47200 -0.440000 0.172000 1.84e-07 4.15e-02
Asparagine N-linked glycosylation 223 3.19e-07 5.94e-06 0.21400 0.214000 -0.013900 4.51e-08 7.23e-01
FCGR3A-mediated phagocytosis 43 3.56e-07 6.17e-06 0.47900 0.478000 0.010300 5.80e-08 9.07e-01
Leishmania phagocytosis 43 3.56e-07 6.17e-06 0.47900 0.478000 0.010300 5.80e-08 9.07e-01
Parasite infection 43 3.56e-07 6.17e-06 0.47900 0.478000 0.010300 5.80e-08 9.07e-01
Ribosomal scanning and start codon recognition 47 3.57e-07 6.17e-06 0.47100 -0.436000 0.178000 2.41e-07 3.49e-02
Transport to the Golgi and subsequent modification 127 3.59e-07 6.17e-06 0.28400 0.279000 -0.054300 6.37e-08 2.92e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 48 5.46e-07 9.26e-06 0.45900 -0.424000 0.176000 3.80e-07 3.47e-02
Signaling by Rho GTPases 258 7.12e-07 1.19e-05 0.19100 0.188000 0.034100 2.54e-07 3.50e-01
Fcgamma receptor (FCGR) dependent phagocytosis 63 7.38e-07 1.21e-05 0.39000 0.387000 -0.048000 1.11e-07 5.11e-01
Beta-catenin independent WNT signaling 105 9.24e-07 1.50e-05 0.28700 0.199000 0.207000 4.36e-04 2.57e-04
Adaptive Immune System 474 9.80e-07 1.57e-05 0.13900 0.131000 0.048000 1.49e-06 7.79e-02
Golgi-to-ER retrograde transport 92 1.53e-06 2.41e-05 0.31200 0.312000 0.004470 2.53e-07 9.41e-01
Signaling by GPCR 228 1.62e-06 2.52e-05 0.20200 0.198000 -0.039100 2.99e-07 3.12e-01
Interleukin-1 family signaling 97 1.83e-06 2.80e-05 0.29400 0.265000 0.127000 6.82e-06 3.17e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 155 1.92e-06 2.90e-05 0.24000 0.240000 -0.005520 2.98e-07 9.06e-01
GPCR downstream signalling 213 1.98e-06 2.96e-05 0.20700 0.203000 -0.040700 3.70e-07 3.09e-01
Signaling by NTRK1 (TRKA) 82 2.03e-06 2.99e-05 0.32100 0.311000 0.080300 1.18e-06 2.10e-01
trans-Golgi Network Vesicle Budding 52 2.07e-06 3.01e-05 0.41500 0.407000 -0.083300 3.92e-07 3.00e-01
Rab regulation of trafficking 89 2.11e-06 3.03e-05 0.31100 0.310000 0.029800 4.65e-07 6.28e-01
RAB GEFs exchange GTP for GDP on RABs 61 2.82e-06 3.99e-05 0.37800 0.373000 -0.059700 4.73e-07 4.21e-01
TCF dependent signaling in response to WNT 117 2.87e-06 4.02e-05 0.26200 0.150000 0.214000 5.16e-03 6.64e-05
COPI-mediated anterograde transport 68 2.95e-06 4.07e-05 0.35900 0.352000 -0.070300 5.54e-07 3.17e-01
Toll-like Receptor Cascades 107 5.02e-06 6.85e-05 0.27300 0.270000 0.043400 1.51e-06 4.39e-01
Gene Silencing by RNA 58 6.21e-06 8.37e-05 0.38500 -0.254000 0.290000 8.54e-04 1.34e-04
RHO GTPases Activate WASPs and WAVEs 29 9.01e-06 1.20e-04 0.52100 0.517000 -0.065000 1.48e-06 5.45e-01
PTEN Regulation 114 1.13e-05 1.49e-04 0.25000 0.168000 0.185000 2.07e-03 6.54e-04
Response to elevated platelet cytosolic Ca2+ 53 1.28e-05 1.66e-04 0.37800 0.377000 -0.024700 2.07e-06 7.56e-01
Activation of the pre-replicative complex 28 1.29e-05 1.66e-04 0.52800 -0.506000 0.151000 3.68e-06 1.67e-01
Toll Like Receptor 4 (TLR4) Cascade 93 1.37e-05 1.74e-04 0.28200 0.280000 0.028300 3.13e-06 6.38e-01
MAPK family signaling cascades 184 1.59e-05 1.97e-04 0.19500 0.160000 0.111000 1.97e-04 9.62e-03
Degradation of the extracellular matrix 35 1.62e-05 1.97e-04 0.45600 0.455000 0.029300 3.27e-06 7.64e-01
Metabolism of non-coding RNA 47 1.62e-05 1.97e-04 0.40300 -0.389000 0.104000 4.03e-06 2.16e-01
snRNP Assembly 47 1.62e-05 1.97e-04 0.40300 -0.389000 0.104000 4.03e-06 2.16e-01
Semaphorin interactions 39 2.27e-05 2.73e-04 0.43500 0.420000 -0.115000 5.81e-06 2.14e-01
Signaling by ROBO receptors 153 2.39e-05 2.85e-04 0.22500 -0.165000 0.153000 4.58e-04 1.16e-03
Cellular response to hypoxia 60 2.49e-05 2.90e-04 0.33300 0.286000 0.170000 1.31e-04 2.29e-02
MAP2K and MAPK activation 25 2.49e-05 2.90e-04 0.52800 0.526000 0.038800 5.23e-06 7.38e-01
Regulation of PTEN stability and activity 56 2.59e-05 2.99e-04 0.34200 0.262000 0.220000 7.09e-04 4.39e-03
Interleukin-1 signaling 78 2.96e-05 3.38e-04 0.29200 0.273000 0.102000 3.10e-05 1.19e-01
Activation of ATR in response to replication stress 34 3.01e-05 3.40e-04 0.46000 -0.442000 0.130000 8.37e-06 1.91e-01
EPHB-mediated forward signaling 24 3.08e-05 3.45e-04 0.53900 0.538000 -0.034800 5.17e-06 7.68e-01
Signaling by NOTCH4 67 3.12e-05 3.45e-04 0.31100 0.253000 0.181000 3.52e-04 1.07e-02
Platelet degranulation 49 3.15e-05 3.46e-04 0.37800 0.376000 -0.040400 5.35e-06 6.25e-01
PCP/CE pathway 71 3.64e-05 3.95e-04 0.29900 0.210000 0.213000 2.25e-03 1.94e-03
DNA strand elongation 27 3.83e-05 4.12e-04 0.50800 -0.497000 0.102000 7.76e-06 3.61e-01
Golgi Associated Vesicle Biogenesis 39 3.93e-05 4.19e-04 0.42700 0.397000 -0.156000 1.79e-05 9.23e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 10 4.57e-05 4.78e-04 0.79200 0.720000 0.332000 8.13e-05 6.94e-02
alpha-linolenic acid (ALA) metabolism 10 4.57e-05 4.78e-04 0.79200 0.720000 0.332000 8.13e-05 6.94e-02
Infectious disease 486 5.46e-05 5.66e-04 0.11500 0.054000 0.102000 4.46e-02 1.50e-04
L1CAM interactions 40 5.64e-05 5.79e-04 0.40600 0.405000 -0.033500 9.71e-06 7.14e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 53 5.81e-05 5.91e-04 0.33800 0.251000 0.226000 1.57e-03 4.49e-03
COPI-independent Golgi-to-ER retrograde traffic 28 5.96e-05 6.01e-04 0.47900 0.479000 0.015100 1.15e-05 8.90e-01
tRNA processing in the nucleus 55 6.34e-05 6.33e-04 0.34600 -0.342000 0.052600 1.17e-05 5.00e-01
RHO GTPase Effectors 184 6.53e-05 6.47e-04 0.18800 0.188000 -0.001330 1.18e-05 9.75e-01
Cargo recognition for clathrin-mediated endocytosis 65 6.85e-05 6.72e-04 0.31100 0.310000 0.032300 1.62e-05 6.53e-01
Signaling by high-kinase activity BRAF mutants 22 7.87e-05 7.66e-04 0.52900 0.524000 0.071700 2.10e-05 5.61e-01
Mitochondrial translation elongation 83 8.52e-05 8.22e-04 0.26900 -0.258000 -0.078200 5.14e-05 2.19e-01
MAPK1/MAPK3 signaling 160 9.46e-05 8.78e-04 0.19100 0.159000 0.107000 5.73e-04 2.03e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 71 9.49e-05 8.78e-04 0.29900 0.295000 -0.046500 1.80e-05 4.99e-01
Toll Like Receptor 2 (TLR2) Cascade 71 9.49e-05 8.78e-04 0.29900 0.295000 -0.046500 1.80e-05 4.99e-01
Toll Like Receptor TLR1:TLR2 Cascade 71 9.49e-05 8.78e-04 0.29900 0.295000 -0.046500 1.80e-05 4.99e-01
Toll Like Receptor TLR6:TLR2 Cascade 71 9.49e-05 8.78e-04 0.29900 0.295000 -0.046500 1.80e-05 4.99e-01
Rev-mediated nuclear export of HIV RNA 33 9.84e-05 9.03e-04 0.44500 -0.394000 0.206000 8.91e-05 4.12e-02
RHO GTPases Activate ROCKs 13 1.05e-04 9.54e-04 0.68400 0.684000 -0.000174 1.96e-05 9.99e-01
Signal transduction by L1 11 1.06e-04 9.54e-04 0.72600 0.682000 0.248000 8.88e-05 1.54e-01
Interactions of Vpr with host cellular proteins 33 1.09e-04 9.72e-04 0.44200 -0.398000 0.192000 7.79e-05 5.59e-02
Signaling by RAF1 mutants 25 1.19e-04 1.06e-03 0.48300 0.471000 0.106000 4.63e-05 3.61e-01
Developmental Biology 448 1.22e-04 1.08e-03 0.11400 0.093100 0.066500 8.66e-04 1.74e-02
Phospholipid metabolism 129 1.28e-04 1.12e-03 0.22000 0.213000 -0.055400 3.15e-05 2.79e-01
Ion channel transport 80 1.31e-04 1.13e-03 0.28300 0.244000 -0.143000 1.71e-04 2.72e-02
RAB geranylgeranylation 38 1.35e-04 1.16e-03 0.39500 0.395000 -0.001750 2.54e-05 9.85e-01
Degradation of beta-catenin by the destruction complex 68 1.53e-04 1.31e-03 0.28400 0.216000 0.183000 2.08e-03 9.07e-03
Programmed Cell Death 134 1.56e-04 1.32e-03 0.20500 0.196000 0.061900 9.64e-05 2.18e-01
tRNA modification in the nucleus and cytosol 34 1.66e-04 1.40e-03 0.42100 -0.404000 0.118000 4.62e-05 2.33e-01
Chromosome Maintenance 74 1.67e-04 1.40e-03 0.28800 -0.264000 0.116000 9.02e-05 8.59e-02
RHO GTPases activate PKNs 25 1.91e-04 1.58e-03 0.46800 0.449000 0.132000 1.03e-04 2.54e-01
Mitochondrial translation initiation 83 1.99e-04 1.64e-03 0.25600 -0.241000 -0.086500 1.52e-04 1.74e-01
Detoxification of Reactive Oxygen Species 23 2.10e-04 1.71e-03 0.50500 0.484000 -0.143000 5.90e-05 2.35e-01
Metabolism of amino acids and derivatives 218 2.13e-04 1.73e-03 0.16700 -0.149000 0.075700 1.63e-04 5.58e-02
Pre-NOTCH Processing in Golgi 15 2.22e-04 1.79e-03 0.58900 0.409000 0.423000 6.07e-03 4.54e-03
FLT3 Signaling 166 2.26e-04 1.81e-03 0.17900 0.149000 0.099100 1.00e-03 2.84e-02
Interactions of Rev with host cellular proteins 34 2.40e-04 1.91e-03 0.41600 -0.370000 0.190000 1.87e-04 5.54e-02
RAF/MAP kinase cascade 155 2.47e-04 1.95e-03 0.18400 0.152000 0.104000 1.17e-03 2.64e-02
Transcriptional regulation by RUNX3 75 2.52e-04 1.97e-03 0.26200 0.191000 0.180000 4.28e-03 7.31e-03
Apoptosis 131 2.55e-04 1.97e-03 0.20200 0.195000 0.054600 1.26e-04 2.82e-01
Rho GTPase cycle 81 2.56e-04 1.97e-03 0.25400 0.226000 0.116000 4.55e-04 7.21e-02
MAPK6/MAPK4 signaling 66 2.66e-04 2.04e-03 0.27800 0.198000 0.196000 5.55e-03 5.97e-03
Degradation of DVL 48 2.71e-04 2.06e-03 0.32600 0.222000 0.238000 7.83e-03 4.32e-03
Mitochondrial translation termination 82 2.80e-04 2.12e-03 0.25300 -0.240000 -0.078500 1.74e-04 2.20e-01
Mitochondrial translation 88 2.85e-04 2.14e-03 0.24400 -0.232000 -0.076000 1.78e-04 2.19e-01
Regulation of ornithine decarboxylase (ODC) 43 2.87e-04 2.14e-03 0.34300 0.258000 0.227000 3.51e-03 1.02e-02
Integration of energy metabolism 58 2.98e-04 2.21e-03 0.31300 0.296000 -0.101000 1.00e-04 1.83e-01
Oncogenic MAPK signaling 56 3.14e-04 2.31e-03 0.31000 0.310000 -0.002260 6.14e-05 9.77e-01
Vpr-mediated nuclear import of PICs 32 3.18e-04 2.32e-03 0.42100 -0.384000 0.171000 1.69e-04 9.49e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 30 3.19e-04 2.32e-03 0.41100 0.373000 0.173000 4.09e-04 1.02e-01
Telomere C-strand (Lagging Strand) Synthesis 29 3.32e-04 2.39e-03 0.44000 -0.407000 0.167000 1.50e-04 1.19e-01
G-protein beta:gamma signalling 20 3.44e-04 2.47e-03 0.50500 0.483000 0.145000 1.84e-04 2.62e-01
Resolution of Abasic Sites (AP sites) 30 3.46e-04 2.47e-03 0.43000 -0.406000 0.143000 1.21e-04 1.76e-01
Metabolism of steroids 81 3.57e-04 2.53e-03 0.26100 0.250000 -0.078000 1.07e-04 2.26e-01
PPARA activates gene expression 79 3.65e-04 2.57e-03 0.25600 0.254000 0.036300 1.01e-04 5.78e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 19 3.71e-04 2.59e-03 0.51300 0.478000 0.185000 3.08e-04 1.62e-01
Negative regulation of NOTCH4 signaling 48 3.79e-04 2.63e-03 0.31900 0.223000 0.229000 7.73e-03 6.17e-03
Sphingolipid metabolism 50 3.95e-04 2.73e-03 0.32900 0.318000 -0.086800 1.04e-04 2.89e-01
Regulation of RUNX3 expression and activity 49 4.44e-04 3.00e-03 0.31300 0.202000 0.239000 1.45e-02 3.88e-03
Paradoxical activation of RAF signaling by kinase inactive BRAF 29 4.47e-04 3.00e-03 0.41400 0.405000 0.086900 1.61e-04 4.19e-01
Signaling by RAS mutants 29 4.47e-04 3.00e-03 0.41400 0.405000 0.086900 1.61e-04 4.19e-01
Signaling by moderate kinase activity BRAF mutants 29 4.47e-04 3.00e-03 0.41400 0.405000 0.086900 1.61e-04 4.19e-01
Signaling downstream of RAS mutants 29 4.47e-04 3.00e-03 0.41400 0.405000 0.086900 1.61e-04 4.19e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 20 4.54e-04 3.02e-03 0.52000 -0.476000 0.210000 2.32e-04 1.04e-01
Signalling to ERKs 26 4.73e-04 3.13e-03 0.43200 0.407000 0.147000 3.34e-04 1.95e-01
Extension of Telomeres 44 5.10e-04 3.36e-03 0.34800 -0.318000 0.142000 2.64e-04 1.04e-01
Defective CFTR causes cystic fibrosis 52 5.37e-04 3.52e-03 0.30100 0.249000 0.168000 1.90e-03 3.64e-02
Interleukin-4 and Interleukin-13 signaling 48 5.42e-04 3.53e-03 0.31400 0.145000 0.278000 8.22e-02 8.70e-04
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 33 5.64e-04 3.63e-03 0.39400 0.385000 -0.085800 1.31e-04 3.94e-01
Transcriptional regulation by RUNX2 82 5.75e-04 3.63e-03 0.23800 0.179000 0.157000 5.21e-03 1.41e-02
MyD88 cascade initiated on plasma membrane 65 5.75e-04 3.63e-03 0.27900 0.277000 -0.029100 1.13e-04 6.85e-01
Toll Like Receptor 10 (TLR10) Cascade 65 5.75e-04 3.63e-03 0.27900 0.277000 -0.029100 1.13e-04 6.85e-01
Toll Like Receptor 5 (TLR5) Cascade 65 5.75e-04 3.63e-03 0.27900 0.277000 -0.029100 1.13e-04 6.85e-01
Transport of the SLBP independent Mature mRNA 33 5.95e-04 3.74e-03 0.40100 -0.330000 0.228000 1.05e-03 2.36e-02
RHO GTPases activate PAKs 13 6.13e-04 3.82e-03 0.61200 0.612000 0.028300 1.34e-04 8.60e-01
Hedgehog ligand biogenesis 51 6.15e-04 3.82e-03 0.30100 0.251000 0.166000 1.95e-03 4.09e-02
NEP/NS2 Interacts with the Cellular Export Machinery 30 6.20e-04 3.84e-03 0.41700 -0.374000 0.185000 4.02e-04 7.95e-02
RHO GTPases activate CIT 14 6.28e-04 3.86e-03 0.57700 0.541000 0.203000 4.63e-04 1.88e-01
ROS and RNS production in phagocytes 23 6.46e-04 3.95e-03 0.46900 0.453000 -0.121000 1.69e-04 3.14e-01
DNA Repair 238 6.57e-04 3.99e-03 0.15000 -0.124000 0.084900 1.12e-03 2.50e-02
Signaling by NOTCH1 50 6.69e-04 4.03e-03 0.30400 0.278000 0.124000 6.95e-04 1.31e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 46 6.72e-04 4.03e-03 0.33700 0.275000 -0.195000 1.25e-03 2.26e-02
Uptake and function of anthrax toxins 10 6.74e-04 4.03e-03 0.67700 0.607000 0.299000 8.90e-04 1.02e-01
Signaling by BRAF and RAF fusions 42 6.83e-04 4.06e-03 0.33800 0.337000 0.025800 1.60e-04 7.72e-01
SARS-CoV Infections 69 6.94e-04 4.11e-03 0.25700 0.224000 0.127000 1.34e-03 6.86e-02
p75 NTR receptor-mediated signalling 60 6.98e-04 4.11e-03 0.27700 0.259000 0.101000 5.43e-04 1.78e-01
Telomere Maintenance 55 7.09e-04 4.15e-03 0.30600 -0.267000 0.151000 6.40e-04 5.32e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 10 7.20e-04 4.20e-03 0.71700 0.604000 -0.387000 9.42e-04 3.43e-02
Metabolism of carbohydrates 177 7.40e-04 4.29e-03 0.16600 0.166000 -0.004310 1.49e-04 9.22e-01
Hedgehog 'on' state 61 7.63e-04 4.36e-03 0.27100 0.207000 0.174000 5.25e-03 1.88e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 27 7.63e-04 4.36e-03 0.41100 0.385000 0.142000 5.35e-04 2.01e-01
Regulation of lipid metabolism by PPARalpha 81 7.64e-04 4.36e-03 0.24100 0.239000 0.030400 2.04e-04 6.38e-01
COPII-mediated vesicle transport 51 8.21e-04 4.66e-03 0.30600 0.306000 -0.023500 1.63e-04 7.72e-01
Cross-presentation of soluble exogenous antigens (endosomes) 38 8.43e-04 4.74e-03 0.34000 0.243000 0.238000 9.69e-03 1.13e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 8.43e-04 4.74e-03 0.32300 0.236000 0.221000 8.18e-03 1.34e-02
Cellular responses to external stimuli 397 8.69e-04 4.84e-03 0.10900 0.019200 0.108000 5.17e-01 2.72e-04
Insulin receptor recycling 17 8.70e-04 4.84e-03 0.52800 0.526000 -0.049100 1.74e-04 7.26e-01
Vif-mediated degradation of APOBEC3G 43 8.80e-04 4.88e-03 0.31900 0.218000 0.232000 1.35e-02 8.44e-03
Antigen processing-Cross presentation 76 9.44e-04 5.20e-03 0.24400 0.241000 0.042100 2.93e-04 5.26e-01
Transport of the SLBP Dependant Mature mRNA 34 9.87e-04 5.41e-03 0.38100 -0.320000 0.207000 1.26e-03 3.69e-02
MyD88 dependent cascade initiated on endosome 67 1.00e-03 5.42e-03 0.26400 0.263000 -0.025600 2.02e-04 7.18e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 67 1.00e-03 5.42e-03 0.26400 0.263000 -0.025600 2.02e-04 7.18e-01
Degradation of GLI1 by the proteasome 51 1.00e-03 5.42e-03 0.29000 0.212000 0.198000 8.91e-03 1.47e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 66 1.04e-03 5.57e-03 0.26600 0.264000 -0.029000 2.11e-04 6.85e-01
Cellular responses to stress 392 1.05e-03 5.64e-03 0.10900 0.011800 0.109000 6.93e-01 2.70e-04
Transferrin endocytosis and recycling 19 1.08e-03 5.74e-03 0.50000 0.475000 -0.155000 3.39e-04 2.43e-01
Base Excision Repair 36 1.09e-03 5.74e-03 0.36500 -0.332000 0.152000 5.65e-04 1.16e-01
Inositol phosphate metabolism 29 1.09e-03 5.74e-03 0.40500 0.380000 -0.142000 4.04e-04 1.88e-01
Regulation of Apoptosis 45 1.10e-03 5.74e-03 0.30700 0.211000 0.222000 1.44e-02 9.96e-03
Opioid Signalling 55 1.10e-03 5.74e-03 0.28400 0.281000 0.043300 3.19e-04 5.79e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 45 1.12e-03 5.85e-03 0.30900 0.286000 0.117000 9.06e-04 1.76e-01
Regulation of RUNX2 expression and activity 57 1.13e-03 5.86e-03 0.27400 0.126000 0.243000 1.01e-01 1.53e-03
RNA Polymerase I Transcription Initiation 41 1.14e-03 5.90e-03 0.34200 -0.305000 0.155000 7.48e-04 8.56e-02
PCNA-Dependent Long Patch Base Excision Repair 18 1.19e-03 6.10e-03 0.51500 -0.445000 0.259000 1.07e-03 5.74e-02
Negative regulation of the PI3K/AKT network 51 1.20e-03 6.12e-03 0.28700 0.244000 0.151000 2.59e-03 6.23e-02
Pre-NOTCH Expression and Processing 41 1.20e-03 6.12e-03 0.31900 0.252000 0.195000 5.20e-03 3.06e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 20 1.22e-03 6.13e-03 0.46400 0.448000 0.121000 5.30e-04 3.51e-01
Neurodegenerative Diseases 20 1.22e-03 6.13e-03 0.46400 0.448000 0.121000 5.30e-04 3.51e-01
Post-translational protein phosphorylation 32 1.22e-03 6.13e-03 0.37800 0.373000 -0.057100 2.61e-04 5.77e-01
Class I MHC mediated antigen processing & presentation 281 1.23e-03 6.15e-03 0.12600 0.124000 0.022600 3.91e-04 5.18e-01
GPVI-mediated activation cascade 24 1.28e-03 6.35e-03 0.42200 0.406000 0.115000 5.87e-04 3.30e-01
TBC/RABGAPs 38 1.32e-03 6.52e-03 0.33300 0.313000 0.114000 8.56e-04 2.24e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 47 1.34e-03 6.62e-03 0.29700 0.252000 0.156000 2.81e-03 6.47e-02
Growth hormone receptor signaling 17 1.36e-03 6.62e-03 0.49000 0.375000 0.316000 7.42e-03 2.43e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 28 1.36e-03 6.62e-03 0.40800 -0.368000 0.175000 7.51e-04 1.10e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 28 1.36e-03 6.62e-03 0.40800 -0.368000 0.175000 7.51e-04 1.10e-01
VEGFA-VEGFR2 Pathway 71 1.38e-03 6.66e-03 0.25200 0.249000 -0.035400 2.93e-04 6.07e-01
Ubiquitin-dependent degradation of Cyclin D 44 1.44e-03 6.92e-03 0.30400 0.191000 0.237000 2.88e-02 6.64e-03
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 1.47e-03 7.04e-03 0.29700 0.211000 0.208000 1.33e-02 1.46e-02
Prolonged ERK activation events 13 1.53e-03 7.30e-03 0.55800 0.482000 0.280000 2.60e-03 8.04e-02
Autophagy 104 1.53e-03 7.31e-03 0.20600 0.205000 -0.023300 3.22e-04 6.83e-01
G beta:gamma signalling through PI3Kgamma 16 1.55e-03 7.33e-03 0.50100 0.413000 0.284000 4.24e-03 4.92e-02
Toll Like Receptor 9 (TLR9) Cascade 70 1.58e-03 7.47e-03 0.24900 0.248000 -0.006100 3.34e-04 9.30e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 46 1.60e-03 7.50e-03 0.29500 0.227000 0.189000 7.90e-03 2.70e-02
HIV Infection 188 1.65e-03 7.70e-03 0.14900 0.038300 0.144000 3.68e-01 7.00e-04
Nuclear import of Rev protein 31 1.66e-03 7.70e-03 0.38100 -0.351000 0.147000 7.18e-04 1.58e-01
p53-Dependent G1 DNA Damage Response 55 1.67e-03 7.70e-03 0.27100 0.118000 0.244000 1.30e-01 1.81e-03
p53-Dependent G1/S DNA damage checkpoint 55 1.67e-03 7.70e-03 0.27100 0.118000 0.244000 1.30e-01 1.81e-03
Neurotransmitter receptors and postsynaptic signal transmission 73 1.74e-03 7.92e-03 0.24500 0.239000 -0.050800 4.16e-04 4.54e-01
Transcriptional regulation by small RNAs 43 1.75e-03 7.92e-03 0.32600 -0.235000 0.225000 7.70e-03 1.06e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 44 1.75e-03 7.92e-03 0.29900 0.196000 0.226000 2.46e-02 9.54e-03
p53-Independent DNA Damage Response 44 1.75e-03 7.92e-03 0.29900 0.196000 0.226000 2.46e-02 9.54e-03
p53-Independent G1/S DNA damage checkpoint 44 1.75e-03 7.92e-03 0.29900 0.196000 0.226000 2.46e-02 9.54e-03
Sema4D in semaphorin signaling 15 1.77e-03 7.99e-03 0.51800 0.492000 0.163000 9.76e-04 2.73e-01
Regulation of signaling by CBL 14 1.78e-03 7.99e-03 0.52900 0.366000 0.382000 1.77e-02 1.34e-02
Recycling pathway of L1 16 1.82e-03 8.15e-03 0.51500 0.513000 -0.044700 3.83e-04 7.57e-01
ER-Phagosome pathway 68 1.83e-03 8.16e-03 0.24300 0.226000 0.088400 1.29e-03 2.09e-01
Lysosome Vesicle Biogenesis 25 1.87e-03 8.31e-03 0.41500 0.405000 -0.093500 4.64e-04 4.19e-01
Degradation of GLI2 by the proteasome 50 1.89e-03 8.34e-03 0.27900 0.206000 0.188000 1.19e-02 2.14e-02
GLI3 is processed to GLI3R by the proteasome 50 1.89e-03 8.34e-03 0.27900 0.206000 0.188000 1.19e-02 2.14e-02
Signaling by VEGF 73 1.98e-03 8.68e-03 0.24100 0.239000 -0.032400 4.30e-04 6.33e-01
Hyaluronan uptake and degradation 10 1.98e-03 8.68e-03 0.64300 0.643000 -0.000604 4.34e-04 9.97e-01
BBSome-mediated cargo-targeting to cilium 19 2.03e-03 8.84e-03 0.45200 -0.399000 -0.213000 2.63e-03 1.09e-01
Signal amplification 19 2.05e-03 8.91e-03 0.45500 0.432000 0.144000 1.12e-03 2.78e-01
Transmission across Chemical Synapses 95 2.19e-03 9.45e-03 0.21400 0.195000 -0.086600 1.03e-03 1.46e-01
Export of Viral Ribonucleoproteins from Nucleus 31 2.27e-03 9.77e-03 0.37200 -0.338000 0.154000 1.12e-03 1.37e-01
G alpha (12/13) signalling events 40 2.30e-03 9.88e-03 0.31100 0.296000 0.096600 1.22e-03 2.91e-01
S Phase 138 2.36e-03 1.01e-02 0.17800 -0.112000 0.138000 2.34e-02 5.16e-03
Neuronal System 128 2.47e-03 1.05e-02 0.18400 0.143000 -0.116000 5.31e-03 2.40e-02
Asymmetric localization of PCP proteins 51 2.48e-03 1.05e-02 0.27100 0.150000 0.225000 6.37e-02 5.42e-03
Glycerophospholipid biosynthesis 71 2.52e-03 1.06e-02 0.24200 0.231000 -0.073000 7.77e-04 2.89e-01
Signaling by MET 42 2.53e-03 1.06e-02 0.30100 0.281000 0.106000 1.62e-03 2.35e-01
Amino acids regulate mTORC1 43 2.55e-03 1.07e-02 0.30000 0.293000 0.061000 8.81e-04 4.89e-01
NS1 Mediated Effects on Host Pathways 38 2.60e-03 1.08e-02 0.33400 -0.288000 0.168000 2.12e-03 7.34e-02
Budding and maturation of HIV virion 24 2.62e-03 1.09e-02 0.39700 0.377000 0.125000 1.40e-03 2.90e-01
Lagging Strand Synthesis 17 2.66e-03 1.10e-02 0.48800 -0.479000 0.095400 6.34e-04 4.96e-01
Metabolism of proteins 1261 2.71e-03 1.12e-02 0.05790 0.042000 0.039800 1.62e-02 2.29e-02
Postmitotic nuclear pore complex (NPC) reformation 26 2.72e-03 1.12e-02 0.39600 -0.384000 0.097000 7.17e-04 3.92e-01
Arachidonic acid metabolism 20 2.73e-03 1.12e-02 0.46000 0.303000 -0.346000 1.90e-02 7.47e-03
Cellular response to heat stress 79 2.74e-03 1.12e-02 0.23200 -0.163000 0.165000 1.24e-02 1.13e-02
Platelet sensitization by LDL 13 2.76e-03 1.12e-02 0.54100 0.531000 0.106000 9.26e-04 5.10e-01
Regulation of HSF1-mediated heat shock response 66 2.78e-03 1.13e-02 0.25300 -0.179000 0.180000 1.22e-02 1.17e-02
Transport of Ribonucleoproteins into the Host Nucleus 30 2.82e-03 1.14e-02 0.37200 -0.333000 0.165000 1.61e-03 1.18e-01
MyD88-independent TLR4 cascade 75 2.93e-03 1.18e-02 0.22500 0.219000 0.047700 1.04e-03 4.76e-01
TRIF(TICAM1)-mediated TLR4 signaling 75 2.93e-03 1.18e-02 0.22500 0.219000 0.047700 1.04e-03 4.76e-01
Hh mutants abrogate ligand secretion 48 2.99e-03 1.19e-02 0.27500 0.235000 0.143000 4.86e-03 8.73e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 77 3.04e-03 1.21e-02 0.21700 0.180000 0.122000 6.57e-03 6.50e-02
Transport of Mature mRNA Derived from an Intronless Transcript 40 3.06e-03 1.22e-02 0.32200 -0.261000 0.189000 4.39e-03 3.90e-02
Regulation of IFNG signaling 13 3.09e-03 1.22e-02 0.52800 0.470000 0.241000 3.36e-03 1.33e-01
Regulation of RAS by GAPs 56 3.12e-03 1.23e-02 0.25300 0.182000 0.176000 1.85e-02 2.33e-02
Neddylation 179 3.19e-03 1.25e-02 0.14200 0.096500 0.105000 2.68e-02 1.65e-02
Activated NOTCH1 Transmits Signal to the Nucleus 19 3.19e-03 1.25e-02 0.43900 0.420000 0.129000 1.53e-03 3.32e-01
G1/S DNA Damage Checkpoints 57 3.25e-03 1.26e-02 0.25200 0.108000 0.228000 1.60e-01 3.00e-03
Anti-inflammatory response favouring Leishmania parasite infection 51 3.26e-03 1.26e-02 0.27400 0.274000 -0.010500 7.19e-04 8.97e-01
Leishmania parasite growth and survival 51 3.26e-03 1.26e-02 0.27400 0.274000 -0.010500 7.19e-04 8.97e-01
Autodegradation of the E3 ubiquitin ligase COP1 43 3.27e-03 1.26e-02 0.28800 0.173000 0.230000 5.01e-02 9.16e-03
ADP signalling through P2Y purinoceptor 12 12 3.29e-03 1.26e-02 0.54300 0.411000 0.355000 1.38e-02 3.32e-02
ABC transporter disorders 56 3.37e-03 1.29e-02 0.25300 0.219000 0.125000 4.57e-03 1.06e-01
PI3K/AKT Signaling in Cancer 48 3.45e-03 1.31e-02 0.27100 0.213000 0.168000 1.08e-02 4.48e-02
Deubiquitination 192 3.46e-03 1.31e-02 0.13700 0.122000 0.062600 3.69e-03 1.37e-01
Stabilization of p53 48 3.46e-03 1.31e-02 0.27100 0.156000 0.222000 6.23e-02 7.85e-03
Fanconi Anemia Pathway 28 3.48e-03 1.31e-02 0.36700 -0.367000 0.000980 7.90e-04 9.93e-01
Interleukin-17 signaling 53 3.48e-03 1.31e-02 0.27400 0.252000 -0.107000 1.51e-03 1.78e-01
SUMO E3 ligases SUMOylate target proteins 130 3.49e-03 1.31e-02 0.17800 -0.121000 0.130000 1.74e-02 1.09e-02
SUMOylation 136 3.54e-03 1.32e-02 0.17400 -0.126000 0.119000 1.13e-02 1.71e-02
Platelet homeostasis 47 3.59e-03 1.34e-02 0.28400 0.283000 -0.014100 7.94e-04 8.67e-01
Processing of Capped Intron-Containing Pre-mRNA 191 3.61e-03 1.34e-02 0.14500 -0.134000 0.055700 1.52e-03 1.87e-01
Cargo concentration in the ER 20 3.64e-03 1.34e-02 0.42600 0.416000 0.089100 1.28e-03 4.91e-01
Thrombin signalling through proteinase activated receptors (PARs) 19 3.64e-03 1.34e-02 0.43700 0.428000 0.088700 1.26e-03 5.04e-01
Collagen degradation 14 3.65e-03 1.34e-02 0.51200 0.509000 0.053100 9.72e-04 7.31e-01
Glycosaminoglycan metabolism 61 3.69e-03 1.35e-02 0.24900 0.248000 -0.016300 8.15e-04 8.26e-01
Hyaluronan metabolism 11 3.77e-03 1.38e-02 0.58500 0.581000 -0.068500 8.45e-04 6.94e-01
C-type lectin receptors (CLRs) 100 3.81e-03 1.39e-02 0.18700 0.163000 0.091700 4.86e-03 1.14e-01
SUMOylation of DNA damage response and repair proteins 67 3.93e-03 1.43e-02 0.24300 -0.211000 0.120000 2.91e-03 8.88e-02
Diseases of programmed cell death 22 3.99e-03 1.45e-02 0.39800 0.370000 0.149000 2.70e-03 2.28e-01
O-linked glycosylation of mucins 26 4.07e-03 1.47e-02 0.38900 0.322000 -0.217000 4.48e-03 5.55e-02
Macroautophagy 95 4.13e-03 1.49e-02 0.19800 0.197000 -0.014700 9.22e-04 8.05e-01
Nuclear Events (kinase and transcription factor activation) 43 4.20e-03 1.50e-02 0.29200 0.292000 -0.014900 9.40e-04 8.66e-01
Muscle contraction 64 4.45e-03 1.59e-02 0.24700 0.189000 -0.159000 9.16e-03 2.81e-02
Extracellular matrix organization 91 4.46e-03 1.59e-02 0.20100 0.200000 -0.026200 1.02e-03 6.67e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 41 4.49e-03 1.59e-02 0.30700 -0.254000 0.173000 4.96e-03 5.62e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript 54 4.50e-03 1.59e-02 0.26800 -0.200000 0.178000 1.10e-02 2.35e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 52 4.72e-03 1.67e-02 0.25300 0.189000 0.169000 1.89e-02 3.57e-02
COPI-dependent Golgi-to-ER retrograde traffic 64 4.75e-03 1.67e-02 0.23600 0.236000 -0.000207 1.10e-03 9.98e-01
G alpha (i) signalling events 111 4.78e-03 1.68e-02 0.18300 0.178000 -0.039800 1.23e-03 4.70e-01
Class A/1 (Rhodopsin-like receptors) 40 4.85e-03 1.70e-02 0.30900 0.240000 -0.194000 8.61e-03 3.36e-02
UCH proteinases 74 4.92e-03 1.72e-02 0.21200 0.163000 0.135000 1.55e-02 4.55e-02
CDK-mediated phosphorylation and removal of Cdc6 62 5.00e-03 1.74e-02 0.23200 0.113000 0.202000 1.23e-01 6.03e-03
CDT1 association with the CDC6:ORC:origin complex 50 5.03e-03 1.74e-02 0.25800 0.129000 0.223000 1.15e-01 6.48e-03
Peptide ligand-binding receptors 16 5.04e-03 1.74e-02 0.48500 0.406000 -0.265000 4.93e-03 6.64e-02
DNA Replication 110 5.13e-03 1.77e-02 0.18600 -0.097900 0.158000 7.72e-02 4.42e-03
Assembly of the pre-replicative complex 59 5.28e-03 1.81e-02 0.23800 0.083200 0.223000 2.70e-01 3.12e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs 56 5.35e-03 1.83e-02 0.24100 0.185000 0.155000 1.69e-02 4.55e-02
Synthesis of DNA 103 5.48e-03 1.87e-02 0.19100 -0.114000 0.153000 4.66e-02 7.38e-03
WNT5A-dependent internalization of FZD4 10 5.56e-03 1.89e-02 0.57400 0.545000 0.183000 2.87e-03 3.17e-01
Nervous system development 305 5.69e-03 1.93e-02 0.10400 0.062200 0.083600 6.43e-02 1.29e-02
Degradation of AXIN 47 5.91e-03 2.00e-02 0.26000 0.178000 0.190000 3.50e-02 2.44e-02
EPH-ephrin mediated repulsion of cells 25 5.93e-03 2.00e-02 0.36200 0.347000 0.102000 2.65e-03 3.78e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 64 6.01e-03 2.02e-02 0.22300 0.156000 0.160000 3.17e-02 2.75e-02
G beta:gamma signalling through CDC42 12 6.08e-03 2.04e-02 0.51300 0.406000 0.314000 1.50e-02 5.94e-02
Viral Messenger RNA Synthesis 40 6.12e-03 2.04e-02 0.30200 -0.241000 0.183000 8.56e-03 4.57e-02
Plasma lipoprotein assembly, remodeling, and clearance 32 6.13e-03 2.04e-02 0.32000 0.309000 0.080400 2.47e-03 4.32e-01
Positive epigenetic regulation of rRNA expression 40 6.47e-03 2.15e-02 0.30100 -0.227000 0.197000 1.30e-02 3.12e-02
SUMOylation of SUMOylation proteins 32 6.66e-03 2.20e-02 0.33400 -0.289000 0.167000 4.74e-03 1.02e-01
Signaling by the B Cell Receptor (BCR) 91 6.77e-03 2.23e-02 0.18500 0.118000 0.143000 5.29e-02 1.88e-02
Fc epsilon receptor (FCERI) signaling 109 6.83e-03 2.25e-02 0.17000 0.152000 0.076200 6.20e-03 1.71e-01
Vpu mediated degradation of CD4 44 6.90e-03 2.26e-02 0.26500 0.178000 0.197000 4.18e-02 2.42e-02
Smooth Muscle Contraction 19 6.90e-03 2.26e-02 0.42400 0.413000 -0.096500 1.84e-03 4.67e-01
CLEC7A (Dectin-1) signaling 84 6.92e-03 2.26e-02 0.19300 0.165000 0.099100 8.93e-03 1.17e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 45 7.00e-03 2.27e-02 0.27400 0.271000 -0.041800 1.69e-03 6.28e-01
Toll Like Receptor 3 (TLR3) Cascade 75 7.01e-03 2.27e-02 0.20700 0.203000 0.041600 2.41e-03 5.35e-01
SUMOylation of RNA binding proteins 42 7.09e-03 2.29e-02 0.28600 -0.274000 0.081700 2.15e-03 3.60e-01
MAP kinase activation 50 7.14e-03 2.30e-02 0.26300 0.249000 -0.083400 2.36e-03 3.09e-01
G-protein activation 13 7.16e-03 2.30e-02 0.48500 0.385000 0.296000 1.63e-02 6.49e-02
Beta-catenin phosphorylation cascade 15 7.19e-03 2.31e-02 0.45900 0.441000 0.126000 3.11e-03 3.99e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 7.25e-03 2.31e-02 0.49100 0.480000 -0.101000 1.87e-03 5.13e-01
Signaling by Erythropoietin 20 7.26e-03 2.31e-02 0.39400 0.359000 0.162000 5.46e-03 2.11e-01
Peptide hormone metabolism 26 7.37e-03 2.34e-02 0.34200 0.245000 0.239000 3.09e-02 3.51e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 10 7.80e-03 2.47e-02 0.58800 -0.331000 0.486000 6.97e-02 7.83e-03
AKT phosphorylates targets in the cytosol 13 8.14e-03 2.57e-02 0.49100 0.485000 0.070500 2.44e-03 6.60e-01
Signaling by Insulin receptor 42 8.21e-03 2.59e-02 0.27200 0.265000 0.059100 2.97e-03 5.08e-01
Death Receptor Signalling 96 8.35e-03 2.63e-02 0.17800 0.166000 0.065800 5.14e-03 2.67e-01
ADP signalling through P2Y purinoceptor 1 15 8.47e-03 2.65e-02 0.45200 0.440000 0.104000 3.17e-03 4.87e-01
Erythropoietin activates RAS 11 8.93e-03 2.79e-02 0.51700 0.439000 0.273000 1.18e-02 1.16e-01
SUMOylation of chromatin organization proteins 49 8.95e-03 2.79e-02 0.26100 -0.235000 0.112000 4.43e-03 1.74e-01
Protein folding 63 9.02e-03 2.80e-02 0.21600 0.180000 0.120000 1.39e-02 9.94e-02
Activation of NF-kappaB in B cells 57 9.27e-03 2.87e-02 0.22600 0.160000 0.159000 3.70e-02 3.76e-02
SCF(Skp2)-mediated degradation of p27/p21 52 9.32e-03 2.88e-02 0.23800 0.113000 0.209000 1.61e-01 9.15e-03
Formation of the beta-catenin:TCF transactivating complex 24 9.34e-03 2.88e-02 0.35600 0.045800 0.353000 6.98e-01 2.74e-03
RNA Polymerase I Promoter Clearance 44 9.41e-03 2.88e-02 0.27400 -0.244000 0.125000 5.20e-03 1.51e-01
RNA Polymerase I Transcription 44 9.41e-03 2.88e-02 0.27400 -0.244000 0.125000 5.20e-03 1.51e-01
Downstream signaling events of B Cell Receptor (BCR) 70 9.44e-03 2.89e-02 0.20400 0.107000 0.174000 1.23e-01 1.19e-02
Plasma lipoprotein clearance 19 9.78e-03 2.98e-02 0.39600 0.384000 0.093700 3.74e-03 4.80e-01
Transport of bile salts and organic acids, metal ions and amine compounds 30 9.81e-03 2.98e-02 0.32600 0.316000 -0.082200 2.80e-03 4.36e-01
Phosphorylation of CD3 and TCR zeta chains 10 9.88e-03 2.99e-02 0.56100 -0.095400 0.552000 6.02e-01 2.49e-03
G beta:gamma signalling through BTK 10 9.91e-03 3.00e-02 0.53500 0.331000 0.420000 7.00e-02 2.15e-02
TNFR2 non-canonical NF-kB pathway 67 9.99e-03 3.01e-02 0.20800 0.105000 0.179000 1.37e-01 1.14e-02
TCR signaling 88 1.03e-02 3.10e-02 0.18000 0.104000 0.147000 9.25e-02 1.72e-02
ERK/MAPK targets 17 1.05e-02 3.14e-02 0.42900 0.417000 -0.100000 2.90e-03 4.73e-01
Gap junction trafficking and regulation 10 1.11e-02 3.31e-02 0.55800 0.534000 -0.165000 3.49e-03 3.66e-01
SUMOylation of ubiquitinylation proteins 37 1.11e-02 3.31e-02 0.29600 -0.204000 0.214000 3.17e-02 2.47e-02
G1/S Transition 113 1.13e-02 3.35e-02 0.16900 -0.085600 0.145000 1.17e-01 7.80e-03
DNA Replication Pre-Initiation 72 1.13e-02 3.35e-02 0.20700 -0.038300 0.203000 5.75e-01 2.93e-03
Transport of Mature Transcript to Cytoplasm 63 1.13e-02 3.35e-02 0.22600 -0.160000 0.160000 2.82e-02 2.84e-02
RHO GTPases Activate NADPH Oxidases 14 1.14e-02 3.37e-02 0.45400 0.443000 0.098500 4.13e-03 5.24e-01
APC/C:Cdc20 mediated degradation of Securin 58 1.16e-02 3.40e-02 0.21900 0.140000 0.168000 6.59e-02 2.70e-02
Cell death signalling via NRAGE, NRIF and NADE 46 1.16e-02 3.40e-02 0.25300 0.252000 0.019200 3.15e-03 8.22e-01
G alpha (q) signalling events 72 1.16e-02 3.40e-02 0.20200 0.202000 0.013200 3.11e-03 8.46e-01
Other semaphorin interactions 10 1.17e-02 3.41e-02 0.56500 0.406000 -0.393000 2.64e-02 3.16e-02
EGFR downregulation 20 1.17e-02 3.42e-02 0.38400 0.384000 0.004960 2.98e-03 9.69e-01
Regulation of insulin secretion 38 1.21e-02 3.51e-02 0.28700 0.256000 -0.128000 6.31e-03 1.71e-01
Processive synthesis on the lagging strand 13 1.23e-02 3.56e-02 0.47600 -0.475000 0.029800 3.01e-03 8.52e-01
ABC-family proteins mediated transport 72 1.23e-02 3.56e-02 0.19500 0.148000 0.127000 2.99e-02 6.37e-02
Translesion synthesis by POLI 15 1.26e-02 3.62e-02 0.45700 -0.354000 0.289000 1.77e-02 5.26e-02
SLC-mediated transmembrane transport 97 1.28e-02 3.67e-02 0.18000 0.151000 -0.097000 1.03e-02 9.98e-02
tRNA Aminoacylation 23 1.29e-02 3.71e-02 0.34700 -0.328000 -0.111000 6.44e-03 3.55e-01
Glycosphingolipid metabolism 27 1.31e-02 3.73e-02 0.32900 0.328000 -0.031900 3.24e-03 7.74e-01
Integrin signaling 17 1.31e-02 3.73e-02 0.41600 0.412000 -0.057000 3.30e-03 6.84e-01
Platelet Aggregation (Plug Formation) 17 1.31e-02 3.73e-02 0.41600 0.412000 -0.057000 3.30e-03 6.84e-01
HDR through Homologous Recombination (HRR) 58 1.33e-02 3.77e-02 0.22700 -0.221000 0.051100 3.68e-03 5.02e-01
Late endosomal microautophagy 23 1.34e-02 3.79e-02 0.35000 0.348000 0.039300 3.88e-03 7.44e-01
Nucleobase biosynthesis 10 1.37e-02 3.85e-02 0.53600 -0.535000 0.037600 3.39e-03 8.37e-01
GABA receptor activation 18 1.37e-02 3.85e-02 0.39000 0.370000 0.122000 6.62e-03 3.70e-01
DNA Double-Strand Break Repair 112 1.37e-02 3.85e-02 0.16600 -0.131000 0.102000 1.68e-02 6.24e-02
Glucagon signaling in metabolic regulation 17 1.37e-02 3.85e-02 0.41500 0.407000 -0.082300 3.68e-03 5.57e-01
Dectin-1 mediated noncanonical NF-kB signaling 52 1.38e-02 3.86e-02 0.22600 0.166000 0.153000 3.84e-02 5.61e-02
G beta:gamma signalling through PLC beta 12 1.40e-02 3.88e-02 0.47100 0.400000 0.248000 1.65e-02 1.36e-01
Presynaptic function of Kainate receptors 12 1.40e-02 3.88e-02 0.47100 0.400000 0.248000 1.65e-02 1.36e-01
Thromboxane signalling through TP receptor 14 1.40e-02 3.88e-02 0.43600 0.363000 0.240000 1.86e-02 1.20e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 40 1.43e-02 3.90e-02 0.25900 0.239000 0.101000 9.04e-03 2.70e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 40 1.43e-02 3.90e-02 0.25900 0.239000 0.101000 9.04e-03 2.70e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 40 1.43e-02 3.90e-02 0.25900 0.239000 0.101000 9.04e-03 2.70e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 40 1.43e-02 3.90e-02 0.25900 0.239000 0.101000 9.04e-03 2.70e-01
Signaling by NOTCH1 in Cancer 40 1.43e-02 3.90e-02 0.25900 0.239000 0.101000 9.04e-03 2.70e-01
G alpha (z) signalling events 24 1.43e-02 3.90e-02 0.33300 0.293000 0.159000 1.31e-02 1.79e-01
Unwinding of DNA 10 1.43e-02 3.90e-02 0.53900 -0.527000 0.112000 3.90e-03 5.41e-01
Recognition of DNA damage by PCNA-containing replication complex 26 1.43e-02 3.90e-02 0.34000 -0.304000 0.151000 7.35e-03 1.82e-01
Chaperonin-mediated protein folding 57 1.44e-02 3.90e-02 0.21600 0.188000 0.107000 1.45e-02 1.62e-01
NIK-->noncanonical NF-kB signaling 51 1.46e-02 3.94e-02 0.22700 0.171000 0.149000 3.48e-02 6.57e-02
Energy dependent regulation of mTOR by LKB1-AMPK 26 1.49e-02 4.03e-02 0.32700 0.327000 0.006740 3.89e-03 9.53e-01
Sema4D induced cell migration and growth-cone collapse 12 1.51e-02 4.06e-02 0.47500 0.464000 0.100000 5.41e-03 5.48e-01
MTOR signalling 36 1.51e-02 4.07e-02 0.27300 0.264000 0.071500 6.21e-03 4.59e-01
Axon guidance 293 1.53e-02 4.10e-02 0.09550 0.057400 0.076300 9.41e-02 2.59e-02
Mitochondrial tRNA aminoacylation 18 1.53e-02 4.10e-02 0.38200 -0.348000 -0.158000 1.06e-02 2.45e-01
Autodegradation of Cdh1 by Cdh1:APC/C 56 1.55e-02 4.12e-02 0.21500 0.135000 0.167000 8.04e-02 3.05e-02
Mitochondrial protein import 47 1.55e-02 4.12e-02 0.24700 -0.241000 0.056600 4.37e-03 5.03e-01
Peroxisomal lipid metabolism 22 1.55e-02 4.12e-02 0.34300 0.230000 0.254000 6.22e-02 3.93e-02
Downstream TCR signaling 72 1.57e-02 4.15e-02 0.19000 0.098400 0.163000 1.50e-01 1.71e-02
VxPx cargo-targeting to cilium 16 1.58e-02 4.17e-02 0.40500 0.377000 0.148000 9.03e-03 3.07e-01
Antigen processing: Ubiquitination & Proteasome degradation 236 1.59e-02 4.21e-02 0.10600 0.087200 0.059800 2.20e-02 1.17e-01
SARS-CoV-1 Infection 43 1.61e-02 4.24e-02 0.24400 0.192000 0.150000 2.92e-02 8.83e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 10 1.62e-02 4.24e-02 0.51600 0.507000 0.096800 5.49e-03 5.96e-01
RAF activation 28 1.69e-02 4.43e-02 0.30900 0.308000 0.029700 4.86e-03 7.86e-01
RNA Polymerase I Promoter Escape 27 1.71e-02 4.47e-02 0.32300 -0.311000 0.086900 5.21e-03 4.35e-01
Frs2-mediated activation 11 1.72e-02 4.48e-02 0.48100 0.420000 0.234000 1.59e-02 1.80e-01
Mitotic G2-G2/M phases 157 1.74e-02 4.52e-02 0.12700 0.088000 0.092100 5.84e-02 4.75e-02
Epigenetic regulation of gene expression 75 1.74e-02 4.52e-02 0.19700 -0.131000 0.148000 5.04e-02 2.75e-02
Translesion synthesis by REV1 14 1.76e-02 4.55e-02 0.45400 -0.376000 0.253000 1.49e-02 1.01e-01
HCMV Early Events 50 1.77e-02 4.57e-02 0.23900 -0.212000 0.110000 9.53e-03 1.78e-01
XBP1(S) activates chaperone genes 36 1.77e-02 4.57e-02 0.27200 0.272000 0.007140 4.72e-03 9.41e-01
Transcriptional regulation by RUNX1 133 1.78e-02 4.57e-02 0.13800 0.074800 0.116000 1.38e-01 2.11e-02
Prostacyclin signalling through prostacyclin receptor 11 1.80e-02 4.61e-02 0.47500 0.343000 0.329000 4.87e-02 5.91e-02
SCF-beta-TrCP mediated degradation of Emi1 47 1.80e-02 4.62e-02 0.23000 0.151000 0.174000 7.32e-02 3.96e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 23 1.84e-02 4.69e-02 0.34800 -0.326000 0.124000 6.90e-03 3.04e-01
HIV Life Cycle 127 1.84e-02 4.69e-02 0.14900 -0.050800 0.140000 3.25e-01 6.63e-03
Activation of gene expression by SREBF (SREBP) 34 1.85e-02 4.70e-02 0.29000 0.235000 -0.169000 1.76e-02 8.88e-02
Orc1 removal from chromatin 61 1.86e-02 4.73e-02 0.20700 0.018900 0.206000 7.99e-01 5.36e-03
FCERI mediated MAPK activation 25 1.87e-02 4.73e-02 0.32700 0.326000 -0.024500 4.78e-03 8.32e-01
GPCR ligand binding 67 1.90e-02 4.80e-02 0.20400 0.187000 -0.081800 8.18e-03 2.48e-01
Constitutive Signaling by Aberrant PI3K in Cancer 24 2.07e-02 5.21e-02 0.31700 0.179000 0.262000 1.30e-01 2.64e-02
Host Interactions of HIV factors 106 2.07e-02 5.21e-02 0.15900 -0.029700 0.156000 5.98e-01 5.69e-03
ESR-mediated signaling 112 2.09e-02 5.24e-02 0.14700 0.085000 0.120000 1.22e-01 2.84e-02
Synthesis of IP3 and IP4 in the cytosol 15 2.10e-02 5.25e-02 0.42500 0.392000 -0.163000 8.55e-03 2.74e-01
Post-chaperonin tubulin folding pathway 13 2.11e-02 5.26e-02 0.43200 0.395000 0.177000 1.38e-02 2.70e-01
Nuclear Pore Complex (NPC) Disassembly 34 2.11e-02 5.27e-02 0.28400 -0.250000 0.133000 1.16e-02 1.79e-01
Synthesis of PIPs at the plasma membrane 36 2.12e-02 5.28e-02 0.27300 0.260000 -0.083000 7.04e-03 3.89e-01
Signaling by NOTCH3 29 2.15e-02 5.31e-02 0.29100 0.281000 0.078400 8.98e-03 4.65e-01
Homologous DNA Pairing and Strand Exchange 38 2.15e-02 5.31e-02 0.26200 -0.260000 0.033800 5.66e-03 7.19e-01
Switching of origins to a post-replicative state 79 2.15e-02 5.31e-02 0.18100 -0.008560 0.181000 8.96e-01 5.60e-03
HSP90 chaperone cycle for steroid hormone receptors (SHR) 32 2.20e-02 5.43e-02 0.27900 0.276000 0.037600 6.86e-03 7.13e-01
Late Phase of HIV Life Cycle 115 2.24e-02 5.51e-02 0.15100 -0.030600 0.148000 5.72e-01 6.30e-03
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 2.27e-02 5.55e-02 0.47500 -0.382000 0.281000 2.19e-02 9.17e-02
Ca2+ pathway 39 2.27e-02 5.55e-02 0.24600 0.144000 0.199000 1.19e-01 3.18e-02
activated TAK1 mediates p38 MAPK activation 13 2.29e-02 5.60e-02 0.43200 0.419000 0.104000 8.90e-03 5.17e-01
Iron uptake and transport 38 2.30e-02 5.61e-02 0.26400 0.245000 -0.096300 8.90e-03 3.05e-01
Diseases of carbohydrate metabolism 22 2.31e-02 5.61e-02 0.34800 0.312000 -0.154000 1.14e-02 2.11e-01
RNA Polymerase I Transcription Termination 26 2.32e-02 5.63e-02 0.31700 -0.300000 0.104000 8.17e-03 3.58e-01
MicroRNA (miRNA) biogenesis 20 2.33e-02 5.63e-02 0.36100 -0.105000 0.345000 4.16e-01 7.54e-03
Notch-HLH transcription pathway 21 2.33e-02 5.63e-02 0.34000 0.334000 0.065200 8.10e-03 6.05e-01
Sphingolipid de novo biosynthesis 23 2.34e-02 5.64e-02 0.34000 0.304000 -0.151000 1.16e-02 2.11e-01
G2/M Transition 155 2.35e-02 5.65e-02 0.12300 0.080700 0.093300 8.44e-02 4.61e-02
TP53 Regulates Metabolic Genes 72 2.39e-02 5.75e-02 0.18500 0.185000 0.012700 6.84e-03 8.52e-01
Activation of GABAB receptors 17 2.41e-02 5.77e-02 0.37100 0.338000 0.154000 1.60e-02 2.71e-01
GABA B receptor activation 17 2.41e-02 5.77e-02 0.37100 0.338000 0.154000 1.60e-02 2.71e-01
NRAGE signals death through JNK 31 2.42e-02 5.78e-02 0.27900 0.273000 0.054200 8.49e-03 6.02e-01
Collagen formation 27 2.46e-02 5.86e-02 0.31400 0.236000 -0.207000 3.39e-02 6.34e-02
Processive synthesis on the C-strand of the telomere 17 2.50e-02 5.92e-02 0.39400 -0.311000 0.241000 2.63e-02 8.50e-02
Collagen biosynthesis and modifying enzymes 17 2.51e-02 5.92e-02 0.39400 0.233000 -0.317000 9.66e-02 2.36e-02
Intraflagellar transport 35 2.51e-02 5.92e-02 0.27000 -0.260000 0.072700 7.85e-03 4.57e-01
Post NMDA receptor activation events 37 2.51e-02 5.92e-02 0.26700 0.175000 -0.202000 6.56e-02 3.37e-02
Signaling by SCF-KIT 33 2.52e-02 5.92e-02 0.26700 0.252000 0.085900 1.22e-02 3.94e-01
Dual Incision in GG-NER 35 2.52e-02 5.92e-02 0.26800 -0.264000 0.048400 6.99e-03 6.20e-01
Extra-nuclear estrogen signaling 48 2.59e-02 6.08e-02 0.21700 0.146000 0.161000 8.06e-02 5.39e-02
ADORA2B mediated anti-inflammatory cytokines production 30 2.61e-02 6.10e-02 0.28200 0.280000 0.034100 8.03e-03 7.47e-01
O-linked glycosylation 42 2.61e-02 6.10e-02 0.24700 0.094000 -0.228000 2.93e-01 1.06e-02
Metabolism of polyamines 48 2.68e-02 6.23e-02 0.21600 0.158000 0.148000 5.83e-02 7.71e-02
Stimuli-sensing channels 39 2.68e-02 6.23e-02 0.25800 0.181000 -0.184000 5.09e-02 4.67e-02
IRE1alpha activates chaperones 37 2.80e-02 6.50e-02 0.25200 0.251000 0.025500 8.44e-03 7.89e-01
Negative regulation of MET activity 16 2.89e-02 6.68e-02 0.37700 0.365000 0.093100 1.14e-02 5.19e-01
Termination of translesion DNA synthesis 28 2.89e-02 6.68e-02 0.29900 -0.269000 0.129000 1.37e-02 2.37e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 25 2.93e-02 6.77e-02 0.31800 -0.251000 0.195000 2.99e-02 9.21e-02
Sema3A PAK dependent Axon repulsion 11 2.99e-02 6.88e-02 0.47800 0.337000 -0.340000 5.33e-02 5.12e-02
B-WICH complex positively regulates rRNA expression 27 3.05e-02 7.00e-02 0.30300 -0.265000 0.147000 1.74e-02 1.85e-01
SUMOylation of DNA replication proteins 43 3.05e-02 7.00e-02 0.24100 -0.180000 0.161000 4.15e-02 6.80e-02
Biological oxidations 78 3.10e-02 7.09e-02 0.17400 0.025700 -0.173000 6.95e-01 8.58e-03
Activation of kainate receptors upon glutamate binding 16 3.11e-02 7.11e-02 0.36600 0.277000 0.240000 5.56e-02 9.61e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 21 3.12e-02 7.11e-02 0.32800 0.326000 0.040700 9.81e-03 7.47e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 63 3.12e-02 7.11e-02 0.18500 0.105000 0.153000 1.49e-01 3.66e-02
Signaling by EGFR 36 3.22e-02 7.30e-02 0.25300 0.253000 -0.009480 8.79e-03 9.22e-01
Transcriptional Regulation by TP53 296 3.25e-02 7.36e-02 0.08930 -0.003250 0.089200 9.24e-01 8.89e-03
Removal of the Flap Intermediate 12 3.27e-02 7.39e-02 0.43900 -0.435000 0.060300 9.06e-03 7.18e-01
G alpha (s) signalling events 44 3.29e-02 7.43e-02 0.22500 0.221000 0.039200 1.13e-02 6.54e-01
Response of Mtb to phagocytosis 20 3.35e-02 7.55e-02 0.32900 0.312000 0.102000 1.56e-02 4.29e-01
Infection with Mycobacterium tuberculosis 22 3.36e-02 7.55e-02 0.31400 0.304000 0.081600 1.37e-02 5.08e-01
Polymerase switching on the C-strand of the telomere 22 3.41e-02 7.65e-02 0.32700 -0.308000 0.110000 1.25e-02 3.70e-01
Potential therapeutics for SARS 26 3.49e-02 7.80e-02 0.28700 0.273000 0.087300 1.59e-02 4.41e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 66 3.55e-02 7.93e-02 0.17800 0.111000 0.138000 1.18e-01 5.26e-02
Amyloid fiber formation 24 3.59e-02 8.00e-02 0.29800 0.284000 0.087900 1.60e-02 4.56e-01
DARPP-32 events 20 3.62e-02 8.05e-02 0.33900 0.326000 -0.091800 1.17e-02 4.78e-01
Presynaptic phase of homologous DNA pairing and strand exchange 35 3.67e-02 8.14e-02 0.25200 -0.251000 0.018100 1.01e-02 8.53e-01
Interleukin-10 signaling 13 3.69e-02 8.18e-02 0.42600 0.284000 -0.318000 7.64e-02 4.72e-02
Factors involved in megakaryocyte development and platelet production 86 3.78e-02 8.36e-02 0.16000 0.160000 -0.010800 1.05e-02 8.63e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 54 3.82e-02 8.44e-02 0.20800 -0.166000 0.126000 3.50e-02 1.11e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 62 3.83e-02 8.44e-02 0.18100 0.101000 0.150000 1.68e-01 4.10e-02
mTORC1-mediated signalling 21 3.88e-02 8.54e-02 0.31100 0.275000 0.146000 2.94e-02 2.46e-01
LDL clearance 13 3.94e-02 8.65e-02 0.39900 0.383000 0.111000 1.68e-02 4.90e-01
Mismatch Repair 13 3.99e-02 8.74e-02 0.42100 -0.326000 0.266000 4.18e-02 9.68e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 18 4.02e-02 8.79e-02 0.35500 -0.154000 0.319000 2.58e-01 1.90e-02
Spry regulation of FGF signaling 15 4.04e-02 8.82e-02 0.38000 0.378000 -0.043100 1.14e-02 7.73e-01
Signaling by Leptin 10 4.06e-02 8.82e-02 0.44600 0.374000 0.244000 4.08e-02 1.81e-01
Homology Directed Repair 88 4.06e-02 8.82e-02 0.16100 -0.142000 0.076200 2.17e-02 2.18e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 65 4.10e-02 8.90e-02 0.17500 0.108000 0.137000 1.32e-01 5.59e-02
Chromatin modifying enzymes 150 4.15e-02 8.97e-02 0.12200 -0.038400 0.116000 4.19e-01 1.46e-02
Chromatin organization 150 4.15e-02 8.97e-02 0.12200 -0.038400 0.116000 4.19e-01 1.46e-02
Transcriptional regulation of granulopoiesis 24 4.16e-02 8.97e-02 0.30300 0.291000 -0.084500 1.37e-02 4.74e-01
Diseases associated with the TLR signaling cascade 15 4.29e-02 9.22e-02 0.36900 0.365000 0.058200 1.46e-02 6.96e-01
Diseases of Immune System 15 4.29e-02 9.22e-02 0.36900 0.365000 0.058200 1.46e-02 6.96e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 10 4.32e-02 9.25e-02 0.47400 0.364000 -0.304000 4.65e-02 9.58e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 10 4.32e-02 9.25e-02 0.44100 0.287000 0.335000 1.17e-01 6.65e-02
Interleukin-6 family signaling 12 4.34e-02 9.27e-02 0.40500 0.365000 0.176000 2.86e-02 2.92e-01
HDACs deacetylate histones 28 4.36e-02 9.29e-02 0.26300 0.184000 0.188000 9.25e-02 8.46e-02
M Phase 292 4.39e-02 9.33e-02 0.08280 0.047700 0.067700 1.65e-01 4.85e-02
FCERI mediated NF-kB activation 64 4.43e-02 9.40e-02 0.17400 0.128000 0.118000 7.73e-02 1.03e-01
Cyclin A:Cdk2-associated events at S phase entry 74 4.44e-02 9.40e-02 0.16400 0.061800 0.151000 3.59e-01 2.46e-02
RNA Polymerase III Transcription Initiation From Type 2 Promoter 24 4.48e-02 9.48e-02 0.30500 -0.229000 0.201000 5.24e-02 8.86e-02
Ub-specific processing proteases 131 4.56e-02 9.62e-02 0.12200 0.076800 0.094300 1.31e-01 6.34e-02
Translesion synthesis by POLK 15 4.59e-02 9.67e-02 0.38200 -0.321000 0.207000 3.13e-02 1.65e-01
Vasopressin regulates renal water homeostasis via Aquaporins 21 4.64e-02 9.73e-02 0.30800 0.304000 0.051100 1.60e-02 6.85e-01
Activation of G protein gated Potassium channels 11 4.65e-02 9.73e-02 0.41500 0.286000 0.301000 1.00e-01 8.42e-02
G protein gated Potassium channels 11 4.65e-02 9.73e-02 0.41500 0.286000 0.301000 1.00e-01 8.42e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 11 4.65e-02 9.73e-02 0.41500 0.286000 0.301000 1.00e-01 8.42e-02
Mitotic Anaphase 193 4.72e-02 9.81e-02 0.09990 0.068100 0.073100 1.05e-01 8.16e-02
ERKs are inactivated 12 4.72e-02 9.81e-02 0.41400 0.412000 -0.043700 1.35e-02 7.93e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 15 4.73e-02 9.81e-02 0.35800 0.331000 0.138000 2.66e-02 3.55e-01
Regulation of TP53 Activity 131 4.73e-02 9.81e-02 0.13000 -0.092200 0.091700 6.96e-02 7.10e-02
Peroxisomal protein import 48 4.80e-02 9.94e-02 0.20000 0.182000 0.082000 2.91e-02 3.27e-01
Cyclin E associated events during G1/S transition 72 4.80e-02 9.94e-02 0.16300 0.075400 0.145000 2.70e-01 3.44e-02
Transcriptional regulation of white adipocyte differentiation 55 4.81e-02 9.94e-02 0.19400 0.192000 -0.026100 1.40e-02 7.39e-01
Interleukin-6 signaling 10 4.88e-02 1.01e-01 0.43200 0.326000 0.284000 7.42e-02 1.20e-01
Activation of HOX genes during differentiation 38 4.90e-02 1.01e-01 0.22700 0.041700 0.223000 6.57e-01 1.75e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 38 4.90e-02 1.01e-01 0.22700 0.041700 0.223000 6.57e-01 1.75e-02
PLC beta mediated events 30 4.92e-02 1.01e-01 0.26300 0.254000 -0.070500 1.62e-02 5.04e-01
Cell Cycle 516 4.99e-02 1.02e-01 0.06610 -0.036500 0.055200 1.63e-01 3.49e-02
Synthesis of PC 19 5.27e-02 1.08e-01 0.31100 0.271000 0.153000 4.08e-02 2.50e-01
HATs acetylate histones 58 5.37e-02 1.09e-01 0.19000 -0.160000 0.102000 3.51e-02 1.81e-01
MET promotes cell motility 13 5.38e-02 1.09e-01 0.37300 0.259000 0.268000 1.06e-01 9.39e-02
G-protein mediated events 31 5.39e-02 1.09e-01 0.25500 0.247000 -0.061300 1.73e-02 5.55e-01
Mitotic G1 phase and G1/S transition 127 5.39e-02 1.09e-01 0.12800 -0.050500 0.117000 3.28e-01 2.29e-02
Generation of second messenger molecules 16 5.45e-02 1.10e-01 0.35700 -0.326000 0.146000 2.40e-02 3.11e-01
Costimulation by the CD28 family 45 5.46e-02 1.10e-01 0.20400 0.047300 0.199000 5.84e-01 2.14e-02
Misspliced GSK3beta mutants stabilize beta-catenin 13 5.58e-02 1.12e-01 0.37900 0.373000 0.069400 2.01e-02 6.65e-01
S33 mutants of beta-catenin aren't phosphorylated 13 5.58e-02 1.12e-01 0.37900 0.373000 0.069400 2.01e-02 6.65e-01
S37 mutants of beta-catenin aren't phosphorylated 13 5.58e-02 1.12e-01 0.37900 0.373000 0.069400 2.01e-02 6.65e-01
S45 mutants of beta-catenin aren't phosphorylated 13 5.58e-02 1.12e-01 0.37900 0.373000 0.069400 2.01e-02 6.65e-01
T41 mutants of beta-catenin aren't phosphorylated 13 5.58e-02 1.12e-01 0.37900 0.373000 0.069400 2.01e-02 6.65e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 13 5.58e-02 1.12e-01 0.37900 0.373000 0.069400 2.01e-02 6.65e-01
Cardiac conduction 42 5.60e-02 1.12e-01 0.21900 0.073000 -0.206000 4.14e-01 2.08e-02
Hedgehog 'off' state 75 5.61e-02 1.12e-01 0.15500 0.113000 0.105000 9.05e-02 1.16e-01
Removal of the Flap Intermediate from the C-strand 15 5.64e-02 1.12e-01 0.37100 -0.266000 0.258000 7.48e-02 8.35e-02
Signaling by TGFB family members 73 5.76e-02 1.14e-01 0.15800 0.150000 0.051000 2.73e-02 4.52e-01
Mitotic Metaphase and Anaphase 194 5.80e-02 1.15e-01 0.09630 0.062800 0.073000 1.34e-01 8.16e-02
MAPK targets/ Nuclear events mediated by MAP kinases 24 5.83e-02 1.15e-01 0.28500 0.278000 -0.063900 1.85e-02 5.88e-01
mRNA Splicing - Major Pathway 144 5.93e-02 1.17e-01 0.11700 -0.113000 0.030600 1.97e-02 5.28e-01
Fatty acid metabolism 102 5.94e-02 1.17e-01 0.13500 0.134000 0.016500 1.97e-02 7.74e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 25 5.94e-02 1.17e-01 0.26800 0.254000 0.086200 2.81e-02 4.56e-01
Dual incision in TC-NER 55 5.95e-02 1.17e-01 0.19200 -0.154000 0.114000 4.80e-02 1.45e-01
Signaling by Hedgehog 97 6.01e-02 1.18e-01 0.13700 0.133000 0.032000 2.37e-02 5.88e-01
Signaling by Non-Receptor Tyrosine Kinases 33 6.04e-02 1.18e-01 0.23300 0.224000 0.065800 2.62e-02 5.13e-01
Signaling by PTK6 33 6.04e-02 1.18e-01 0.23300 0.224000 0.065800 2.62e-02 5.13e-01
SUMOylation of intracellular receptors 18 6.06e-02 1.18e-01 0.31100 0.172000 0.260000 2.07e-01 5.66e-02
PI Metabolism 59 6.24e-02 1.21e-01 0.17900 0.177000 -0.024800 1.87e-02 7.42e-01
Apoptotic execution phase 33 6.35e-02 1.23e-01 0.24300 0.220000 -0.102000 2.88e-02 3.10e-01
Oncogene Induced Senescence 30 6.45e-02 1.25e-01 0.23800 0.190000 0.144000 7.22e-02 1.73e-01
Regulation of TP53 Activity through Acetylation 26 6.50e-02 1.26e-01 0.27200 -0.109000 0.249000 3.37e-01 2.81e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 68 6.52e-02 1.26e-01 0.17000 -0.136000 0.102000 5.27e-02 1.48e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 22 6.67e-02 1.29e-01 0.27700 0.157000 0.228000 2.03e-01 6.45e-02
Interleukin-20 family signaling 13 6.74e-02 1.30e-01 0.35800 0.277000 0.228000 8.40e-02 1.55e-01
Interleukin receptor SHC signaling 16 6.78e-02 1.30e-01 0.32300 0.225000 0.231000 1.19e-01 1.10e-01
Signaling by Nuclear Receptors 147 6.88e-02 1.32e-01 0.10700 0.080600 0.070300 9.31e-02 1.43e-01
Metabolism of steroid hormones 12 6.98e-02 1.34e-01 0.37000 0.271000 0.253000 1.05e-01 1.30e-01
Keratan sulfate/keratin metabolism 19 7.00e-02 1.34e-01 0.29800 0.283000 0.094700 3.28e-02 4.75e-01
mRNA Splicing 151 7.02e-02 1.34e-01 0.11100 -0.108000 0.024200 2.27e-02 6.10e-01
Interleukin-37 signaling 17 7.03e-02 1.34e-01 0.31100 0.247000 0.190000 7.85e-02 1.75e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 7.04e-02 1.34e-01 0.39700 -0.331000 0.220000 4.75e-02 1.88e-01
DNA Damage Bypass 41 7.26e-02 1.38e-01 0.21400 -0.166000 0.136000 6.68e-02 1.33e-01
Role of LAT2/NTAL/LAB on calcium mobilization 11 7.33e-02 1.39e-01 0.40400 0.392000 -0.099400 2.45e-02 5.68e-01
RNA Polymerase III Chain Elongation 16 7.38e-02 1.40e-01 0.34000 -0.288000 0.182000 4.63e-02 2.09e-01
Amino acid transport across the plasma membrane 16 7.38e-02 1.40e-01 0.33700 0.118000 -0.316000 4.14e-01 2.88e-02
Nucleotide Excision Repair 98 7.48e-02 1.41e-01 0.13800 -0.111000 0.082300 5.87e-02 1.60e-01
Cell Cycle, Mitotic 418 7.59e-02 1.43e-01 0.06670 -0.017500 0.064400 5.45e-01 2.60e-02
Deadenylation of mRNA 21 7.61e-02 1.43e-01 0.28800 -0.038300 0.286000 7.61e-01 2.35e-02
Activation of NMDA receptors and postsynaptic events 42 7.66e-02 1.44e-01 0.20900 0.129000 -0.165000 1.49e-01 6.46e-02
Gluconeogenesis 24 7.70e-02 1.44e-01 0.27300 0.256000 -0.094200 2.99e-02 4.25e-01
E3 ubiquitin ligases ubiquitinate target proteins 41 7.73e-02 1.45e-01 0.19700 0.162000 0.112000 7.27e-02 2.14e-01
Adrenaline,noradrenaline inhibits insulin secretion 14 7.82e-02 1.46e-01 0.33600 0.235000 0.240000 1.29e-01 1.20e-01
Carboxyterminal post-translational modifications of tubulin 20 7.91e-02 1.47e-01 0.28400 0.268000 0.093100 3.79e-02 4.71e-01
NOTCH1 Intracellular Domain Regulates Transcription 36 7.96e-02 1.48e-01 0.20900 0.166000 0.127000 8.49e-02 1.88e-01
Cellular Senescence 105 7.97e-02 1.48e-01 0.12400 0.110000 0.055900 5.19e-02 3.24e-01
Synthesis of very long-chain fatty acyl-CoAs 16 8.08e-02 1.50e-01 0.32300 0.000701 0.323000 9.96e-01 2.53e-02
G2/M Checkpoints 116 8.15e-02 1.51e-01 0.12200 -0.026500 0.119000 6.23e-01 2.68e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 10 8.26e-02 1.53e-01 0.42000 0.208000 -0.365000 2.54e-01 4.56e-02
Signaling by FGFR1 in disease 26 8.27e-02 1.53e-01 0.26100 0.139000 -0.221000 2.19e-01 5.13e-02
Nuclear Envelope Breakdown 49 8.30e-02 1.53e-01 0.19100 -0.123000 0.146000 1.36e-01 7.75e-02
Leading Strand Synthesis 12 8.76e-02 1.61e-01 0.37000 -0.368000 0.046500 2.75e-02 7.81e-01
Polymerase switching 12 8.76e-02 1.61e-01 0.37000 -0.368000 0.046500 2.75e-02 7.81e-01
InlB-mediated entry of Listeria monocytogenes into host cell 11 8.79e-02 1.61e-01 0.37200 0.331000 0.170000 5.72e-02 3.30e-01
Regulation of MECP2 expression and activity 23 8.84e-02 1.62e-01 0.25800 0.105000 0.235000 3.82e-01 5.09e-02
HDR through Single Strand Annealing (SSA) 34 8.89e-02 1.63e-01 0.22000 -0.217000 0.034200 2.84e-02 7.30e-01
Aquaporin-mediated transport 22 8.94e-02 1.63e-01 0.26800 0.266000 0.030100 3.08e-02 8.07e-01
Interleukin-2 family signaling 29 9.32e-02 1.70e-01 0.22600 0.189000 0.123000 7.82e-02 2.50e-01
FGFR1 mutant receptor activation 21 9.33e-02 1.70e-01 0.28300 0.245000 -0.142000 5.21e-02 2.61e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 14 9.35e-02 1.70e-01 0.34200 0.330000 -0.087800 3.26e-02 5.70e-01
Cholesterol biosynthesis 20 9.41e-02 1.71e-01 0.28700 0.269000 -0.099300 3.71e-02 4.42e-01
Gastrin-CREB signalling pathway via PKC and MAPK 12 9.64e-02 1.75e-01 0.37100 0.327000 -0.175000 4.96e-02 2.94e-01
RNA Polymerase III Transcription Initiation 33 9.68e-02 1.75e-01 0.22500 -0.152000 0.167000 1.32e-01 9.80e-02
Insulin processing 17 9.70e-02 1.75e-01 0.29100 0.204000 0.208000 1.45e-01 1.38e-01
Cilium Assembly 152 9.71e-02 1.75e-01 0.10500 -0.095700 0.042200 4.27e-02 3.72e-01
Glucagon-type ligand receptors 13 9.77e-02 1.76e-01 0.33400 0.187000 0.277000 2.45e-01 8.44e-02
Global Genome Nucleotide Excision Repair (GG-NER) 76 9.79e-02 1.76e-01 0.14800 -0.128000 0.074600 5.50e-02 2.62e-01
Translesion Synthesis by POLH 16 9.79e-02 1.76e-01 0.32300 -0.219000 0.237000 1.30e-01 1.01e-01
mRNA decay by 3' to 5' exoribonuclease 14 9.86e-02 1.77e-01 0.32100 -0.268000 -0.177000 8.30e-02 2.52e-01
Retinoid metabolism and transport 10 9.97e-02 1.78e-01 0.38200 0.354000 0.142000 5.26e-02 4.36e-01
Condensation of Prophase Chromosomes 11 1.00e-01 1.79e-01 0.36000 -0.272000 -0.235000 1.18e-01 1.77e-01
Regulation of IFNA signaling 12 1.01e-01 1.80e-01 0.34700 0.322000 0.130000 5.33e-02 4.36e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 82 1.03e-01 1.82e-01 0.14100 -0.120000 0.073600 6.05e-02 2.50e-01
Negative epigenetic regulation of rRNA expression 43 1.03e-01 1.82e-01 0.19500 -0.152000 0.122000 8.53e-02 1.66e-01
PIWI-interacting RNA (piRNA) biogenesis 15 1.03e-01 1.82e-01 0.32900 -0.187000 0.270000 2.10e-01 7.00e-02
RET signaling 22 1.03e-01 1.82e-01 0.26000 0.259000 0.027200 3.58e-02 8.25e-01
Citric acid cycle (TCA cycle) 19 1.03e-01 1.83e-01 0.27200 0.216000 0.166000 1.04e-01 2.10e-01
Calnexin/calreticulin cycle 23 1.04e-01 1.83e-01 0.25200 0.246000 0.054300 4.11e-02 6.52e-01
Sialic acid metabolism 23 1.04e-01 1.83e-01 0.26200 0.249000 -0.081300 3.91e-02 5.00e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 23 1.04e-01 1.83e-01 0.24700 0.152000 0.195000 2.07e-01 1.06e-01
Signaling by NOTCH2 18 1.04e-01 1.83e-01 0.28600 0.282000 0.044700 3.84e-02 7.43e-01
GAB1 signalosome 10 1.05e-01 1.85e-01 0.37800 0.356000 0.126000 5.11e-02 4.90e-01
Deposition of new CENPA-containing nucleosomes at the centromere 20 1.07e-01 1.86e-01 0.27500 -0.273000 0.035000 3.46e-02 7.87e-01
Nucleosome assembly 20 1.07e-01 1.86e-01 0.27500 -0.273000 0.035000 3.46e-02 7.87e-01
Disorders of transmembrane transporters 105 1.07e-01 1.87e-01 0.11600 0.056700 0.101000 3.17e-01 7.46e-02
FCGR3A-mediated IL10 synthesis 22 1.11e-01 1.94e-01 0.26600 0.125000 -0.235000 3.12e-01 5.66e-02
Apoptotic cleavage of cellular proteins 25 1.13e-01 1.96e-01 0.24700 0.232000 -0.083100 4.45e-02 4.72e-01
SUMOylation of immune response proteins 10 1.13e-01 1.97e-01 0.36800 0.215000 0.299000 2.40e-01 1.02e-01
Nucleobase catabolism 22 1.14e-01 1.98e-01 0.25700 0.257000 -0.007530 3.73e-02 9.51e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 34 1.14e-01 1.98e-01 0.21400 -0.156000 0.146000 1.15e-01 1.41e-01
RNA polymerase II transcribes snRNA genes 63 1.15e-01 1.99e-01 0.14700 0.075400 0.126000 3.02e-01 8.48e-02
AMER1 mutants destabilize the destruction complex 12 1.16e-01 1.99e-01 0.34300 0.341000 0.031500 4.06e-02 8.50e-01
APC truncation mutants have impaired AXIN binding 12 1.16e-01 1.99e-01 0.34300 0.341000 0.031500 4.06e-02 8.50e-01
AXIN missense mutants destabilize the destruction complex 12 1.16e-01 1.99e-01 0.34300 0.341000 0.031500 4.06e-02 8.50e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 12 1.16e-01 1.99e-01 0.34300 0.341000 0.031500 4.06e-02 8.50e-01
Truncations of AMER1 destabilize the destruction complex 12 1.16e-01 1.99e-01 0.34300 0.341000 0.031500 4.06e-02 8.50e-01
truncated APC mutants destabilize the destruction complex 12 1.16e-01 1.99e-01 0.34300 0.341000 0.031500 4.06e-02 8.50e-01
Myogenesis 13 1.17e-01 2.00e-01 0.33700 0.328000 -0.073300 4.04e-02 6.47e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 14 1.18e-01 2.01e-01 0.33000 -0.184000 0.274000 2.34e-01 7.60e-02
Protein ubiquitination 59 1.19e-01 2.03e-01 0.15100 0.140000 0.058000 6.38e-02 4.42e-01
Glycogen metabolism 17 1.21e-01 2.06e-01 0.29500 0.276000 -0.103000 4.90e-02 4.62e-01
Intra-Golgi traffic 39 1.21e-01 2.06e-01 0.19200 0.190000 -0.032100 4.07e-02 7.29e-01
Negative regulation of MAPK pathway 36 1.21e-01 2.06e-01 0.19300 0.182000 0.064300 5.89e-02 5.05e-01
NOD1/2 Signaling Pathway 23 1.22e-01 2.07e-01 0.23800 0.140000 0.193000 2.44e-01 1.10e-01
Transcriptional Regulation by MECP2 31 1.23e-01 2.07e-01 0.20500 0.147000 0.142000 1.56e-01 1.70e-01
Negative regulation of FGFR1 signaling 17 1.23e-01 2.07e-01 0.29300 0.274000 -0.104000 5.02e-02 4.60e-01
Negative regulation of FGFR2 signaling 17 1.23e-01 2.07e-01 0.29300 0.274000 -0.104000 5.02e-02 4.60e-01
Negative regulation of FGFR3 signaling 17 1.23e-01 2.07e-01 0.29300 0.274000 -0.104000 5.02e-02 4.60e-01
Negative regulation of FGFR4 signaling 17 1.23e-01 2.07e-01 0.29300 0.274000 -0.104000 5.02e-02 4.60e-01
FOXO-mediated transcription of cell death genes 14 1.23e-01 2.07e-01 0.31500 0.315000 -0.001800 4.12e-02 9.91e-01
The citric acid (TCA) cycle and respiratory electron transport 118 1.27e-01 2.13e-01 0.10500 0.083700 0.063000 1.18e-01 2.39e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 1.30e-01 2.18e-01 0.20400 0.201000 0.032200 4.93e-02 7.53e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 38 1.30e-01 2.18e-01 0.18200 0.133000 0.125000 1.58e-01 1.82e-01
Triglyceride catabolism 11 1.32e-01 2.20e-01 0.35700 0.343000 -0.099400 4.90e-02 5.68e-01
Phase II - Conjugation of compounds 45 1.36e-01 2.27e-01 0.17300 0.021000 -0.172000 8.08e-01 4.62e-02
Antiviral mechanism by IFN-stimulated genes 77 1.37e-01 2.27e-01 0.13500 -0.124000 0.054800 6.14e-02 4.07e-01
Selective autophagy 48 1.37e-01 2.27e-01 0.17200 0.103000 -0.138000 2.19e-01 9.75e-02
NR1H2 and NR1H3-mediated signaling 26 1.37e-01 2.28e-01 0.21800 0.133000 0.173000 2.42e-01 1.28e-01
Activation of BAD and translocation to mitochondria 14 1.41e-01 2.33e-01 0.30300 0.302000 0.024000 5.02e-02 8.76e-01
Cell Cycle Checkpoints 222 1.41e-01 2.33e-01 0.07940 -0.027100 0.074600 4.89e-01 5.72e-02
Cytosolic sensors of pathogen-associated DNA 51 1.46e-01 2.41e-01 0.15700 0.018300 0.156000 8.21e-01 5.40e-02
APC/C-mediated degradation of cell cycle proteins 77 1.48e-01 2.44e-01 0.12500 0.065100 0.106000 3.24e-01 1.07e-01
Regulation of mitotic cell cycle 77 1.48e-01 2.44e-01 0.12500 0.065100 0.106000 3.24e-01 1.07e-01
Pre-NOTCH Transcription and Translation 27 1.48e-01 2.44e-01 0.21100 0.185000 0.101000 9.65e-02 3.66e-01
Regulation of TP53 Activity through Methylation 17 1.50e-01 2.46e-01 0.28200 -0.231000 0.162000 9.91e-02 2.48e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 14 1.50e-01 2.47e-01 0.29000 0.246000 0.154000 1.11e-01 3.18e-01
Platelet calcium homeostasis 16 1.52e-01 2.49e-01 0.29100 0.209000 -0.202000 1.49e-01 1.61e-01
Organelle biogenesis and maintenance 202 1.53e-01 2.51e-01 0.08050 -0.079000 0.015200 5.44e-02 7.12e-01
Ion transport by P-type ATPases 27 1.55e-01 2.53e-01 0.22200 0.183000 -0.126000 1.00e-01 2.57e-01
Constitutive Signaling by AKT1 E17K in Cancer 23 1.55e-01 2.53e-01 0.22800 0.221000 0.055300 6.62e-02 6.46e-01
TP53 Regulates Transcription of DNA Repair Genes 51 1.56e-01 2.54e-01 0.16200 -0.114000 0.116000 1.61e-01 1.54e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 80 1.58e-01 2.56e-01 0.12000 0.099400 0.067700 1.25e-01 2.96e-01
Synthesis of PIPs at the early endosome membrane 12 1.58e-01 2.56e-01 0.30900 0.203000 0.233000 2.24e-01 1.63e-01
Intrinsic Pathway for Apoptosis 45 1.58e-01 2.56e-01 0.16100 0.150000 0.059000 8.18e-02 4.94e-01
Initiation of Nuclear Envelope (NE) Reformation 17 1.60e-01 2.58e-01 0.27100 0.268000 -0.037700 5.60e-02 7.88e-01
Cell recruitment (pro-inflammatory response) 14 1.60e-01 2.58e-01 0.30300 0.279000 -0.119000 7.09e-02 4.43e-01
Purinergic signaling in leishmaniasis infection 14 1.60e-01 2.58e-01 0.30300 0.279000 -0.119000 7.09e-02 4.43e-01
ISG15 antiviral mechanism 70 1.60e-01 2.58e-01 0.13500 -0.130000 0.033500 5.97e-02 6.29e-01
Inwardly rectifying K+ channels 12 1.61e-01 2.59e-01 0.30700 0.230000 0.203000 1.68e-01 2.23e-01
Suppression of phagosomal maturation 12 1.62e-01 2.61e-01 0.31100 0.297000 0.091000 7.48e-02 5.85e-01
NoRC negatively regulates rRNA expression 42 1.63e-01 2.62e-01 0.17600 -0.141000 0.105000 1.14e-01 2.40e-01
RUNX2 regulates bone development 16 1.64e-01 2.62e-01 0.27200 0.271000 0.025500 6.07e-02 8.60e-01
Cell-cell junction organization 12 1.64e-01 2.62e-01 0.31000 -0.097600 -0.294000 5.59e-01 7.81e-02
Diseases associated with glycosylation precursor biosynthesis 18 1.64e-01 2.62e-01 0.26000 0.259000 -0.028800 5.74e-02 8.32e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 14 1.68e-01 2.69e-01 0.30000 0.144000 -0.263000 3.51e-01 8.82e-02
RNA Polymerase III Transcription Initiation From Type 3 Promoter 25 1.70e-01 2.70e-01 0.22600 -0.147000 0.171000 2.03e-01 1.39e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 16 1.73e-01 2.76e-01 0.26000 0.189000 0.179000 1.91e-01 2.14e-01
Deactivation of the beta-catenin transactivating complex 28 1.74e-01 2.76e-01 0.19800 0.083400 0.180000 4.45e-01 9.93e-02
ECM proteoglycans 12 1.74e-01 2.76e-01 0.30500 -0.089300 -0.292000 5.92e-01 8.03e-02
Signaling by FGFR3 26 1.75e-01 2.77e-01 0.21800 0.189000 -0.109000 9.57e-02 3.34e-01
Oxidative Stress Induced Senescence 54 1.76e-01 2.78e-01 0.14300 0.134000 0.049700 8.84e-02 5.29e-01
G1/S-Specific Transcription 25 1.79e-01 2.82e-01 0.22100 -0.195000 0.103000 9.11e-02 3.73e-01
RAF-independent MAPK1/3 activation 20 1.79e-01 2.82e-01 0.23100 0.158000 0.169000 2.22e-01 1.92e-01
Listeria monocytogenes entry into host cells 14 1.79e-01 2.83e-01 0.28300 0.280000 0.040200 7.01e-02 7.95e-01
PKMTs methylate histone lysines 30 1.80e-01 2.84e-01 0.19800 -0.042200 0.193000 6.90e-01 6.69e-02
mRNA 3'-end processing 35 1.81e-01 2.84e-01 0.18200 -0.020800 0.181000 8.31e-01 6.45e-02
Fatty acyl-CoA biosynthesis 26 1.85e-01 2.90e-01 0.20500 0.039400 0.201000 7.29e-01 7.60e-02
Regulation of APC/C activators between G1/S and early anaphase 70 1.86e-01 2.91e-01 0.12300 0.056100 0.110000 4.18e-01 1.14e-01
Diseases associated with glycosaminoglycan metabolism 15 1.90e-01 2.98e-01 0.26400 0.098400 0.245000 5.10e-01 1.00e-01
Signaling by WNT in cancer 22 1.91e-01 2.98e-01 0.22200 0.220000 0.030200 7.48e-02 8.06e-01
Separation of Sister Chromatids 145 1.91e-01 2.99e-01 0.08490 0.045500 0.071700 3.47e-01 1.38e-01
Signaling by cytosolic FGFR1 fusion mutants 18 1.95e-01 3.04e-01 0.25200 0.231000 -0.102000 8.98e-02 4.55e-01
Signaling by Hippo 12 1.96e-01 3.05e-01 0.30800 0.287000 -0.113000 8.55e-02 4.99e-01
Nuclear signaling by ERBB4 16 1.98e-01 3.08e-01 0.26500 0.253000 -0.077300 7.97e-02 5.93e-01
Signaling by ERBB4 31 2.03e-01 3.15e-01 0.19000 0.178000 -0.066200 8.71e-02 5.24e-01
Processing of DNA double-strand break ends 54 2.04e-01 3.17e-01 0.14500 -0.127000 0.068400 1.06e-01 3.86e-01
Interleukin-15 signaling 12 2.07e-01 3.21e-01 0.30000 0.292000 -0.067200 7.97e-02 6.87e-01
Depolymerisation of the Nuclear Lamina 13 2.13e-01 3.29e-01 0.27300 0.236000 0.136000 1.40e-01 3.96e-01
Respiratory electron transport 79 2.13e-01 3.29e-01 0.11100 0.094800 0.057400 1.46e-01 3.79e-01
Retrograde transport at the Trans-Golgi-Network 45 2.14e-01 3.30e-01 0.15500 0.141000 -0.064500 1.01e-01 4.55e-01
Cytochrome P450 - arranged by substrate type 14 2.17e-01 3.34e-01 0.26600 0.262000 0.046500 9.02e-02 7.63e-01
Telomere C-strand synthesis initiation 10 2.17e-01 3.34e-01 0.32700 -0.300000 0.131000 1.01e-01 4.72e-01
SLC transporter disorders 49 2.18e-01 3.35e-01 0.14900 -0.130000 0.072400 1.16e-01 3.82e-01
Metabolism of fat-soluble vitamins 12 2.23e-01 3.42e-01 0.27900 0.241000 0.141000 1.48e-01 3.98e-01
PRC2 methylates histones and DNA 11 2.23e-01 3.42e-01 0.29800 -0.296000 -0.038100 8.97e-02 8.27e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 2.25e-01 3.44e-01 0.29700 0.295000 0.038100 9.05e-02 8.27e-01
Signaling by FGFR1 28 2.26e-01 3.45e-01 0.18800 0.188000 -0.002780 8.53e-02 9.80e-01
Interleukin-7 signaling 14 2.27e-01 3.45e-01 0.25700 0.126000 0.225000 4.15e-01 1.46e-01
RUNX3 regulates p14-ARF 10 2.27e-01 3.45e-01 0.30300 0.239000 0.187000 1.91e-01 3.07e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 15 2.29e-01 3.48e-01 0.26500 0.217000 -0.151000 1.45e-01 3.10e-01
TP53 Regulates Transcription of Cell Cycle Genes 43 2.29e-01 3.48e-01 0.15500 -0.061000 0.143000 4.89e-01 1.06e-01
Diseases associated with N-glycosylation of proteins 15 2.30e-01 3.48e-01 0.25600 -0.005160 0.256000 9.72e-01 8.67e-02
Estrogen-dependent gene expression 68 2.34e-01 3.54e-01 0.11900 0.009680 0.118000 8.90e-01 9.21e-02
Uptake and actions of bacterial toxins 19 2.34e-01 3.54e-01 0.22300 0.221000 0.032700 9.62e-02 8.05e-01
HCMV Late Events 51 2.35e-01 3.54e-01 0.14000 -0.027000 0.137000 7.39e-01 9.12e-02
Defects in vitamin and cofactor metabolism 16 2.35e-01 3.54e-01 0.25200 -0.233000 0.096500 1.07e-01 5.04e-01
ZBP1(DAI) mediated induction of type I IFNs 17 2.37e-01 3.56e-01 0.22900 0.172000 0.151000 2.20e-01 2.80e-01
Unfolded Protein Response (UPR) 70 2.37e-01 3.56e-01 0.11900 0.117000 -0.018900 9.09e-02 7.85e-01
Signaling by Retinoic Acid 17 2.39e-01 3.59e-01 0.23300 -0.048500 -0.228000 7.29e-01 1.04e-01
Signaling by PDGF 25 2.39e-01 3.59e-01 0.19200 0.187000 0.044400 1.06e-01 7.01e-01
NCAM signaling for neurite out-growth 22 2.40e-01 3.59e-01 0.20200 -0.095600 -0.178000 4.38e-01 1.50e-01
PI3K Cascade 18 2.41e-01 3.60e-01 0.23300 -0.054400 0.227000 6.90e-01 9.61e-02
RMTs methylate histone arginines 25 2.41e-01 3.60e-01 0.20100 -0.169000 0.109000 1.43e-01 3.45e-01
SHC1 events in ERBB2 signaling 11 2.42e-01 3.61e-01 0.30000 0.283000 -0.099000 1.05e-01 5.70e-01
Glycogen synthesis 11 2.42e-01 3.61e-01 0.29600 0.291000 -0.054200 9.43e-02 7.56e-01
Cytochrome c-mediated apoptotic response 10 2.44e-01 3.64e-01 0.30300 0.301000 0.035500 9.92e-02 8.46e-01
NGF-stimulated transcription 25 2.46e-01 3.65e-01 0.19100 0.187000 0.037400 1.06e-01 7.46e-01
RUNX3 regulates NOTCH signaling 11 2.46e-01 3.66e-01 0.28100 0.230000 0.161000 1.86e-01 3.55e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 13 2.47e-01 3.66e-01 0.26600 0.022100 0.265000 8.90e-01 9.85e-02
Protein localization 122 2.49e-01 3.68e-01 0.08820 -0.009050 0.087700 8.63e-01 9.55e-02
Regulation of PTEN gene transcription 49 2.51e-01 3.70e-01 0.13200 0.089800 0.097400 2.78e-01 2.39e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 32 2.53e-01 3.74e-01 0.17400 -0.080400 0.155000 4.32e-01 1.30e-01
mRNA Splicing - Minor Pathway 44 2.54e-01 3.74e-01 0.14900 -0.124000 0.083700 1.57e-01 3.37e-01
NOTCH4 Intracellular Domain Regulates Transcription 13 2.55e-01 3.75e-01 0.25800 0.241000 0.091200 1.32e-01 5.69e-01
Early Phase of HIV Life Cycle 13 2.56e-01 3.77e-01 0.27000 -0.255000 0.088200 1.12e-01 5.82e-01
The role of Nef in HIV-1 replication and disease pathogenesis 19 2.57e-01 3.77e-01 0.22200 0.215000 -0.055900 1.05e-01 6.73e-01
Signaling by FGFR2 IIIa TM 14 2.57e-01 3.77e-01 0.25600 -0.033500 0.254000 8.28e-01 9.99e-02
Ca-dependent events 21 2.58e-01 3.79e-01 0.20600 0.205000 0.014800 1.04e-01 9.06e-01
Insulin receptor signalling cascade 26 2.66e-01 3.89e-01 0.17800 0.115000 0.135000 3.09e-01 2.33e-01
Formation of RNA Pol II elongation complex 48 2.67e-01 3.89e-01 0.13300 0.041100 0.126000 6.22e-01 1.31e-01
RNA Polymerase II Transcription Elongation 48 2.67e-01 3.89e-01 0.13300 0.041100 0.126000 6.22e-01 1.31e-01
Caspase activation via extrinsic apoptotic signalling pathway 15 2.69e-01 3.92e-01 0.24300 0.242000 -0.024800 1.05e-01 8.68e-01
Assembly Of The HIV Virion 14 2.70e-01 3.92e-01 0.24500 0.236000 0.064000 1.26e-01 6.79e-01
Regulation of TP53 Activity through Phosphorylation 76 2.70e-01 3.93e-01 0.11100 -0.081700 0.075800 2.19e-01 2.55e-01
mRNA Capping 25 2.74e-01 3.97e-01 0.19000 -0.060500 0.180000 6.01e-01 1.20e-01
RNA Polymerase III Abortive And Retractive Initiation 37 2.75e-01 3.97e-01 0.15800 -0.111000 0.113000 2.45e-01 2.33e-01
RNA Polymerase III Transcription 37 2.75e-01 3.97e-01 0.15800 -0.111000 0.113000 2.45e-01 2.33e-01
Signaling by TGF-beta Receptor Complex 63 2.76e-01 3.99e-01 0.11600 0.116000 0.009380 1.13e-01 8.98e-01
Transcriptional Regulation by E2F6 29 2.83e-01 4.09e-01 0.16700 -0.161000 -0.045500 1.35e-01 6.72e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 13 2.84e-01 4.10e-01 0.24500 0.160000 0.185000 3.18e-01 2.48e-01
Signaling by FGFR4 25 2.85e-01 4.11e-01 0.18800 0.168000 -0.084900 1.46e-01 4.63e-01
Deadenylation-dependent mRNA decay 50 2.88e-01 4.14e-01 0.13300 -0.119000 0.059200 1.46e-01 4.70e-01
Nucleotide salvage 18 2.88e-01 4.14e-01 0.22200 0.189000 -0.117000 1.66e-01 3.92e-01
Triglyceride metabolism 16 2.88e-01 4.14e-01 0.23600 0.189000 -0.141000 1.91e-01 3.30e-01
AURKA Activation by TPX2 59 2.89e-01 4.14e-01 0.11400 0.077200 0.084400 3.06e-01 2.63e-01
FGFR2 alternative splicing 21 2.90e-01 4.15e-01 0.20400 -0.087500 0.184000 4.88e-01 1.44e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 27 2.92e-01 4.17e-01 0.17300 0.011100 0.173000 9.20e-01 1.20e-01
PKA activation 10 2.93e-01 4.17e-01 0.29700 0.225000 -0.193000 2.17e-01 2.91e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 14 2.93e-01 4.17e-01 0.24900 0.222000 -0.113000 1.51e-01 4.66e-01
Formation of HIV elongation complex in the absence of HIV Tat 36 2.94e-01 4.19e-01 0.15300 -0.029900 0.150000 7.56e-01 1.21e-01
Mitophagy 23 2.96e-01 4.21e-01 0.18400 -0.047500 -0.178000 6.94e-01 1.40e-01
HDMs demethylate histones 13 2.97e-01 4.22e-01 0.25900 0.193000 -0.173000 2.29e-01 2.82e-01
Class B/2 (Secretin family receptors) 26 2.98e-01 4.23e-01 0.17000 0.117000 0.123000 3.01e-01 2.78e-01
Synthesis of PA 18 3.03e-01 4.29e-01 0.20500 -0.070600 -0.193000 6.04e-01 1.57e-01
RIP-mediated NFkB activation via ZBP1 14 3.04e-01 4.29e-01 0.23000 0.172000 0.152000 2.65e-01 3.25e-01
The NLRP3 inflammasome 12 3.04e-01 4.29e-01 0.25500 0.253000 0.030500 1.30e-01 8.55e-01
Signalling to RAS 13 3.05e-01 4.30e-01 0.24100 0.225000 0.085700 1.61e-01 5.93e-01
Translation of structural proteins 26 3.05e-01 4.30e-01 0.16900 0.094400 0.140000 4.05e-01 2.18e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 12 3.07e-01 4.32e-01 0.25100 0.240000 0.071000 1.50e-01 6.70e-01
Trafficking of AMPA receptors 12 3.07e-01 4.32e-01 0.25100 0.240000 0.071000 1.50e-01 6.70e-01
Glutathione conjugation 20 3.10e-01 4.35e-01 0.20400 0.100000 -0.177000 4.39e-01 1.70e-01
TGF-beta receptor signaling activates SMADs 32 3.10e-01 4.35e-01 0.15400 0.153000 0.021500 1.35e-01 8.33e-01
CD28 co-stimulation 27 3.11e-01 4.35e-01 0.16400 0.095400 0.134000 3.92e-01 2.30e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 41 3.11e-01 4.35e-01 0.14300 0.094800 -0.107000 2.94e-01 2.36e-01
RNA Polymerase II Pre-transcription Events 65 3.12e-01 4.36e-01 0.10600 0.050400 0.093500 4.83e-01 1.93e-01
ATF4 activates genes in response to endoplasmic reticulum stress 23 3.14e-01 4.39e-01 0.18000 -0.036600 -0.177000 7.61e-01 1.43e-01
RNA Polymerase III Transcription Termination 20 3.16e-01 4.40e-01 0.20100 -0.184000 0.080500 1.54e-01 5.34e-01
Glycogen storage diseases 10 3.18e-01 4.43e-01 0.28600 0.192000 -0.213000 2.93e-01 2.45e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 3.19e-01 4.43e-01 0.24800 0.231000 -0.088300 1.49e-01 5.82e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 12 3.21e-01 4.45e-01 0.24700 0.243000 0.048500 1.46e-01 7.71e-01
FGFR2 mutant receptor activation 15 3.23e-01 4.49e-01 0.22900 -0.083800 0.214000 5.74e-01 1.52e-01
PINK1-PRKN Mediated Mitophagy 18 3.26e-01 4.52e-01 0.19700 -0.112000 -0.162000 4.10e-01 2.35e-01
VEGFR2 mediated vascular permeability 22 3.30e-01 4.57e-01 0.17800 0.159000 0.080000 1.97e-01 5.16e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 10 3.31e-01 4.57e-01 0.28100 -0.192000 0.206000 2.93e-01 2.60e-01
Heparan sulfate/heparin (HS-GAG) metabolism 19 3.31e-01 4.57e-01 0.19000 0.122000 0.146000 3.59e-01 2.71e-01
FOXO-mediated transcription 46 3.32e-01 4.57e-01 0.12400 0.119000 0.033900 1.62e-01 6.92e-01
Josephin domain DUBs 10 3.34e-01 4.59e-01 0.27400 0.268000 -0.058500 1.43e-01 7.49e-01
RORA activates gene expression 10 3.35e-01 4.60e-01 0.27600 0.262000 -0.084500 1.51e-01 6.44e-01
RNA Polymerase II Transcription Termination 42 3.35e-01 4.61e-01 0.13600 -0.058300 0.122000 5.14e-01 1.71e-01
NOTCH3 Intracellular Domain Regulates Transcription 14 3.36e-01 4.61e-01 0.22600 0.226000 0.014300 1.44e-01 9.26e-01
PKA-mediated phosphorylation of CREB 11 3.38e-01 4.63e-01 0.26600 0.176000 -0.199000 3.12e-01 2.53e-01
Cell surface interactions at the vascular wall 57 3.40e-01 4.65e-01 0.11300 0.113000 -0.001610 1.42e-01 9.83e-01
ER Quality Control Compartment (ERQC) 18 3.40e-01 4.65e-01 0.20300 0.197000 -0.049700 1.48e-01 7.15e-01
Class I peroxisomal membrane protein import 19 3.41e-01 4.65e-01 0.20000 -0.087700 0.180000 5.08e-01 1.75e-01
Signaling by ERBB2 32 3.45e-01 4.70e-01 0.14800 0.148000 0.008710 1.48e-01 9.32e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 19 3.50e-01 4.76e-01 0.18600 0.167000 0.082800 2.08e-01 5.32e-01
Meiosis 38 3.51e-01 4.78e-01 0.13500 -0.135000 -0.004310 1.50e-01 9.63e-01
Inhibition of DNA recombination at telomere 16 3.53e-01 4.79e-01 0.21100 -0.038100 0.207000 7.92e-01 1.51e-01
Formation of the Early Elongation Complex 29 3.56e-01 4.83e-01 0.15400 -0.000324 0.154000 9.98e-01 1.52e-01
Formation of the HIV-1 Early Elongation Complex 29 3.56e-01 4.83e-01 0.15400 -0.000324 0.154000 9.98e-01 1.52e-01
Formation of TC-NER Pre-Incision Complex 45 3.59e-01 4.86e-01 0.12700 -0.054500 0.115000 5.27e-01 1.84e-01
G0 and Early G1 24 3.60e-01 4.87e-01 0.17400 -0.143000 0.099900 2.26e-01 3.97e-01
Interleukin-12 family signaling 41 3.61e-01 4.87e-01 0.12600 0.048300 0.116000 5.93e-01 2.00e-01
Heme biosynthesis 10 3.62e-01 4.88e-01 0.25900 0.005300 0.259000 9.77e-01 1.56e-01
Signaling by BMP 14 3.63e-01 4.88e-01 0.21200 0.119000 0.176000 4.41e-01 2.55e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 21 3.65e-01 4.91e-01 0.17800 0.009900 0.178000 9.37e-01 1.59e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 22 3.66e-01 4.92e-01 0.17600 0.031300 -0.174000 8.00e-01 1.59e-01
Regulation of KIT signaling 11 3.69e-01 4.95e-01 0.23900 0.087100 0.223000 6.17e-01 2.00e-01
Loss of Nlp from mitotic centrosomes 56 3.72e-01 4.98e-01 0.10500 0.056900 0.088300 4.63e-01 2.54e-01
Loss of proteins required for interphase microtubule organization from the centrosome 56 3.72e-01 4.98e-01 0.10500 0.056900 0.088300 4.63e-01 2.54e-01
Membrane binding and targetting of GAG proteins 12 3.76e-01 5.03e-01 0.23600 0.232000 -0.041300 1.64e-01 8.04e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 3.76e-01 5.03e-01 0.23600 0.232000 -0.041300 1.64e-01 8.04e-01
Regulation of beta-cell development 14 3.78e-01 5.04e-01 0.21100 0.204000 0.055300 1.88e-01 7.20e-01
Cyclin A/B1/B2 associated events during G2/M transition 22 3.80e-01 5.07e-01 0.16600 0.075100 0.148000 5.42e-01 2.29e-01
Rap1 signalling 10 3.81e-01 5.08e-01 0.24500 0.209000 0.128000 2.53e-01 4.83e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 18 3.82e-01 5.08e-01 0.18200 0.152000 0.101000 2.66e-01 4.57e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 35 3.83e-01 5.08e-01 0.13800 -0.048900 0.130000 6.17e-01 1.85e-01
HIV Transcription Elongation 35 3.83e-01 5.08e-01 0.13800 -0.048900 0.130000 6.17e-01 1.85e-01
Tat-mediated elongation of the HIV-1 transcript 35 3.83e-01 5.08e-01 0.13800 -0.048900 0.130000 6.17e-01 1.85e-01
Keratan sulfate biosynthesis 15 3.88e-01 5.14e-01 0.20000 0.189000 0.064800 2.04e-01 6.64e-01
CTLA4 inhibitory signaling 16 3.91e-01 5.17e-01 0.19200 0.074800 0.177000 6.05e-01 2.20e-01
Metabolism of porphyrins 15 3.92e-01 5.17e-01 0.19700 0.130000 0.148000 3.83e-01 3.23e-01
Interferon alpha/beta signaling 49 3.95e-01 5.20e-01 0.11200 0.001570 0.112000 9.85e-01 1.74e-01
Zinc transporters 11 4.00e-01 5.27e-01 0.24000 0.068800 -0.230000 6.93e-01 1.87e-01
HCMV Infection 71 4.04e-01 5.31e-01 0.09260 -0.003110 0.092600 9.64e-01 1.78e-01
Processing of Intronless Pre-mRNAs 14 4.06e-01 5.33e-01 0.21300 -0.090500 0.193000 5.58e-01 2.12e-01
DNA Double Strand Break Response 34 4.06e-01 5.33e-01 0.13200 0.008630 0.132000 9.31e-01 1.84e-01
Transcription of the HIV genome 55 4.07e-01 5.33e-01 0.10500 -0.004320 0.105000 9.56e-01 1.80e-01
RUNX2 regulates osteoblast differentiation 11 4.08e-01 5.34e-01 0.22600 0.203000 0.099600 2.44e-01 5.68e-01
Metabolism of cofactors 17 4.11e-01 5.37e-01 0.18300 0.178000 0.043000 2.03e-01 7.59e-01
Interferon gamma signaling 55 4.11e-01 5.37e-01 0.10200 0.096100 0.032800 2.18e-01 6.74e-01
Diseases associated with O-glycosylation of proteins 21 4.15e-01 5.41e-01 0.16100 -0.097700 -0.128000 4.39e-01 3.09e-01
Assembly and cell surface presentation of NMDA receptors 11 4.16e-01 5.41e-01 0.23800 -0.203000 0.125000 2.45e-01 4.72e-01
Apoptotic factor-mediated response 14 4.16e-01 5.41e-01 0.20000 0.189000 0.065300 2.22e-01 6.72e-01
Ovarian tumor domain proteases 28 4.19e-01 5.44e-01 0.14500 0.144000 -0.012900 1.87e-01 9.06e-01
Metabolism of vitamins and cofactors 107 4.19e-01 5.44e-01 0.07150 0.060200 0.038700 2.84e-01 4.91e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 22 4.26e-01 5.53e-01 0.15700 0.147000 0.053700 2.32e-01 6.63e-01
Meiotic recombination 16 4.27e-01 5.53e-01 0.18900 -0.189000 0.016300 1.92e-01 9.10e-01
Molecules associated with elastic fibres 12 4.28e-01 5.54e-01 0.21200 -0.061700 -0.203000 7.11e-01 2.23e-01
DAG and IP3 signaling 26 4.30e-01 5.56e-01 0.15200 0.119000 -0.095300 2.94e-01 4.01e-01
Metalloprotease DUBs 16 4.33e-01 5.59e-01 0.18100 0.158000 0.088800 2.76e-01 5.39e-01
CaM pathway 20 4.35e-01 5.60e-01 0.16800 0.167000 -0.021700 1.98e-01 8.67e-01
Calmodulin induced events 20 4.35e-01 5.60e-01 0.16800 0.167000 -0.021700 1.98e-01 8.67e-01
Post-translational modification: synthesis of GPI-anchored proteins 28 4.36e-01 5.61e-01 0.14200 -0.021800 0.140000 8.42e-01 1.99e-01
Synthesis of substrates in N-glycan biosythesis 49 4.39e-01 5.64e-01 0.10800 0.104000 -0.028900 2.09e-01 7.27e-01
Complex I biogenesis 41 4.39e-01 5.64e-01 0.11400 0.113000 0.018100 2.12e-01 8.42e-01
Nuclear Envelope (NE) Reassembly 60 4.41e-01 5.66e-01 0.09250 0.046300 0.080100 5.36e-01 2.84e-01
Telomere Extension By Telomerase 20 4.45e-01 5.70e-01 0.17000 -0.107000 0.132000 4.07e-01 3.06e-01
Assembly of collagen fibrils and other multimeric structures 14 4.48e-01 5.73e-01 0.19800 0.195000 -0.032300 2.07e-01 8.34e-01
Interferon Signaling 142 4.50e-01 5.74e-01 0.06300 -0.020700 0.059500 6.71e-01 2.23e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 4.50e-01 5.74e-01 0.15200 0.152000 -0.001850 2.07e-01 9.88e-01
Transcription of E2F targets under negative control by DREAM complex 18 4.50e-01 5.74e-01 0.17800 -0.152000 0.092600 2.66e-01 4.97e-01
Diseases of metabolism 120 4.53e-01 5.76e-01 0.06610 0.065800 0.006770 2.15e-01 8.99e-01
DAP12 interactions 23 4.54e-01 5.77e-01 0.15400 0.147000 -0.046300 2.22e-01 7.01e-01
TICAM1-dependent activation of IRF3/IRF7 12 4.54e-01 5.77e-01 0.20900 -0.007130 0.209000 9.66e-01 2.09e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 4.57e-01 5.80e-01 0.21300 -0.065800 0.202000 6.93e-01 2.25e-01
Tie2 Signaling 10 4.59e-01 5.81e-01 0.22500 0.221000 0.040200 2.26e-01 8.26e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 33 4.60e-01 5.82e-01 0.12500 0.008560 0.124000 9.32e-01 2.17e-01
E2F mediated regulation of DNA replication 18 4.61e-01 5.83e-01 0.16300 -0.134000 -0.093600 3.25e-01 4.92e-01
Circadian Clock 50 4.63e-01 5.85e-01 0.10400 0.098700 -0.031400 2.28e-01 7.01e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 33 4.65e-01 5.87e-01 0.12000 0.091400 0.077700 3.64e-01 4.40e-01
Processing of Capped Intronless Pre-mRNA 21 4.70e-01 5.93e-01 0.15900 -0.142000 0.072000 2.60e-01 5.68e-01
DAP12 signaling 21 4.74e-01 5.96e-01 0.15600 0.152000 -0.034600 2.27e-01 7.84e-01
CD28 dependent PI3K/Akt signaling 18 4.74e-01 5.96e-01 0.17200 -0.095600 0.143000 4.83e-01 2.94e-01
G2/M DNA damage checkpoint 53 4.76e-01 5.97e-01 0.09640 -0.096300 -0.004520 2.26e-01 9.55e-01
Reproduction 43 4.77e-01 5.98e-01 0.10700 -0.107000 -0.006320 2.28e-01 9.43e-01
CLEC7A (Dectin-1) induces NFAT activation 11 4.78e-01 5.98e-01 0.21200 -0.015600 0.212000 9.29e-01 2.24e-01
RNA Pol II CTD phosphorylation and interaction with CE 23 4.83e-01 6.04e-01 0.14600 -0.014900 0.145000 9.02e-01 2.28e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 23 4.83e-01 6.04e-01 0.14600 -0.014900 0.145000 9.02e-01 2.28e-01
HIV elongation arrest and recovery 26 4.85e-01 6.06e-01 0.13500 0.012000 0.135000 9.15e-01 2.35e-01
Pausing and recovery of HIV elongation 26 4.85e-01 6.06e-01 0.13500 0.012000 0.135000 9.15e-01 2.35e-01
Phase I - Functionalization of compounds 30 4.88e-01 6.08e-01 0.12900 0.047000 -0.121000 6.56e-01 2.53e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 19 4.93e-01 6.14e-01 0.15500 -0.150000 -0.037300 2.58e-01 7.78e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 4.93e-01 6.14e-01 0.15500 -0.150000 -0.037300 2.58e-01 7.78e-01
TRAF6 mediated NF-kB activation 18 4.96e-01 6.16e-01 0.16300 0.160000 -0.028900 2.39e-01 8.32e-01
Protein-protein interactions at synapses 31 4.98e-01 6.17e-01 0.12100 -0.012700 -0.121000 9.03e-01 2.45e-01
Role of phospholipids in phagocytosis 16 4.98e-01 6.17e-01 0.17600 0.143000 -0.104000 3.23e-01 4.74e-01
Effects of PIP2 hydrolysis 19 4.99e-01 6.17e-01 0.16200 -0.134000 0.091000 3.14e-01 4.93e-01
Bile acid and bile salt metabolism 14 5.00e-01 6.17e-01 0.18800 0.156000 -0.105000 3.14e-01 4.95e-01
TRAF6 mediated IRF7 activation 15 5.00e-01 6.17e-01 0.17400 0.174000 0.012100 2.44e-01 9.35e-01
Nuclear Receptor transcription pathway 25 5.03e-01 6.21e-01 0.14000 -0.074700 0.118000 5.18e-01 3.07e-01
Recruitment of NuMA to mitotic centrosomes 64 5.05e-01 6.23e-01 0.08290 0.021300 0.080100 7.69e-01 2.69e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 41 5.13e-01 6.31e-01 0.10100 0.080400 0.060600 3.74e-01 5.02e-01
Response of EIF2AK1 (HRI) to heme deficiency 13 5.13e-01 6.31e-01 0.18800 0.183000 -0.041500 2.53e-01 7.96e-01
Formation of tubulin folding intermediates by CCT/TriC 14 5.14e-01 6.31e-01 0.17300 0.152000 0.082300 3.26e-01 5.94e-01
Regulation of TNFR1 signaling 28 5.14e-01 6.31e-01 0.12900 -0.117000 0.054800 2.83e-01 6.16e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 28 5.20e-01 6.37e-01 0.12100 0.104000 0.061500 3.41e-01 5.74e-01
Signaling by FGFR 51 5.24e-01 6.41e-01 0.08900 0.073600 0.049900 3.64e-01 5.38e-01
SUMOylation of DNA methylation proteins 14 5.24e-01 6.41e-01 0.17000 -0.154000 -0.073000 3.19e-01 6.37e-01
Cytosolic sulfonation of small molecules 10 5.29e-01 6.47e-01 0.21100 0.079000 -0.196000 6.66e-01 2.84e-01
Glutamate Neurotransmitter Release Cycle 11 5.36e-01 6.54e-01 0.18700 -0.120000 -0.144000 4.92e-01 4.08e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 5.39e-01 6.56e-01 0.16700 -0.166000 0.018700 2.66e-01 9.00e-01
Disorders of developmental biology 10 5.40e-01 6.56e-01 0.19800 0.184000 0.070500 3.13e-01 6.99e-01
Loss of function of MECP2 in Rett syndrome 10 5.40e-01 6.56e-01 0.19800 0.184000 0.070500 3.13e-01 6.99e-01
Pervasive developmental disorders 10 5.40e-01 6.56e-01 0.19800 0.184000 0.070500 3.13e-01 6.99e-01
Trafficking and processing of endosomal TLR 10 5.47e-01 6.64e-01 0.20000 0.200000 0.005150 2.75e-01 9.77e-01
Nicotinate metabolism 19 5.48e-01 6.64e-01 0.14600 0.145000 -0.013800 2.73e-01 9.17e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 27 5.52e-01 6.69e-01 0.12400 0.115000 -0.047500 3.02e-01 6.69e-01
Sulfur amino acid metabolism 15 5.53e-01 6.69e-01 0.16800 -0.121000 0.117000 4.17e-01 4.33e-01
APC-Cdc20 mediated degradation of Nek2A 24 5.54e-01 6.70e-01 0.12700 -0.126000 -0.015500 2.87e-01 8.95e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 16 5.56e-01 6.71e-01 0.15100 -0.075000 -0.132000 6.04e-01 3.63e-01
Inflammasomes 16 5.57e-01 6.72e-01 0.15100 0.129000 0.079200 3.74e-01 5.83e-01
Downregulation of ERBB2 signaling 15 5.58e-01 6.72e-01 0.16000 0.160000 0.009970 2.85e-01 9.47e-01
Termination of O-glycan biosynthesis 10 5.58e-01 6.72e-01 0.19100 0.167000 0.092800 3.61e-01 6.12e-01
Caspase-mediated cleavage of cytoskeletal proteins 10 5.60e-01 6.73e-01 0.20300 0.175000 -0.102000 3.37e-01 5.76e-01
Downstream signal transduction 21 5.64e-01 6.77e-01 0.13100 0.117000 0.058900 3.54e-01 6.41e-01
Ephrin signaling 11 5.68e-01 6.78e-01 0.19200 0.125000 -0.145000 4.72e-01 4.05e-01
HIV Transcription Initiation 37 5.69e-01 6.78e-01 0.09780 0.048100 0.085100 6.13e-01 3.71e-01
RNA Polymerase II HIV Promoter Escape 37 5.69e-01 6.78e-01 0.09780 0.048100 0.085100 6.13e-01 3.71e-01
RNA Polymerase II Promoter Escape 37 5.69e-01 6.78e-01 0.09780 0.048100 0.085100 6.13e-01 3.71e-01
RNA Polymerase II Transcription Initiation 37 5.69e-01 6.78e-01 0.09780 0.048100 0.085100 6.13e-01 3.71e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 37 5.69e-01 6.78e-01 0.09780 0.048100 0.085100 6.13e-01 3.71e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 37 5.69e-01 6.78e-01 0.09780 0.048100 0.085100 6.13e-01 3.71e-01
Ion homeostasis 26 5.71e-01 6.80e-01 0.12400 0.087500 -0.088400 4.40e-01 4.35e-01
Signaling by NTRK3 (TRKC) 12 5.71e-01 6.80e-01 0.17200 -0.050800 -0.165000 7.61e-01 3.23e-01
Signaling by FGFR2 in disease 23 5.72e-01 6.80e-01 0.13200 -0.103000 0.082800 3.95e-01 4.92e-01
Elastic fibre formation 17 5.73e-01 6.80e-01 0.15300 0.107000 -0.110000 4.45e-01 4.34e-01
Centrosome maturation 65 5.74e-01 6.80e-01 0.07390 0.022100 0.070600 7.59e-01 3.26e-01
Recruitment of mitotic centrosome proteins and complexes 65 5.74e-01 6.80e-01 0.07390 0.022100 0.070600 7.59e-01 3.26e-01
Formation of Incision Complex in GG-NER 36 5.75e-01 6.80e-01 0.10500 -0.089000 0.055000 3.56e-01 5.68e-01
RIPK1-mediated regulated necrosis 13 5.81e-01 6.86e-01 0.16100 0.090300 0.134000 5.73e-01 4.05e-01
Regulated Necrosis 13 5.81e-01 6.86e-01 0.16100 0.090300 0.134000 5.73e-01 4.05e-01
Polo-like kinase mediated events 15 5.86e-01 6.90e-01 0.14900 0.096600 0.113000 5.17e-01 4.49e-01
Diseases of glycosylation 68 5.86e-01 6.90e-01 0.07000 0.049400 0.049600 4.82e-01 4.80e-01
Anchoring of the basal body to the plasma membrane 80 5.91e-01 6.95e-01 0.06780 -0.020600 0.064600 7.51e-01 3.19e-01
IRS-mediated signalling 21 5.93e-01 6.97e-01 0.13300 -0.064200 0.116000 6.11e-01 3.57e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 13 5.96e-01 7.00e-01 0.16700 -0.156000 0.059600 3.31e-01 7.10e-01
Signaling by FGFR in disease 40 5.97e-01 7.00e-01 0.09600 0.078900 -0.054700 3.88e-01 5.50e-01
TNFR1-induced proapoptotic signaling 11 5.97e-01 7.00e-01 0.17200 -0.156000 -0.072600 3.72e-01 6.77e-01
Synthesis of bile acids and bile salts 13 6.00e-01 7.02e-01 0.16700 0.141000 -0.090100 3.80e-01 5.74e-01
FCERI mediated Ca+2 mobilization 25 6.02e-01 7.04e-01 0.11500 0.115000 0.011000 3.21e-01 9.24e-01
Signaling by NTRK2 (TRKB) 16 6.17e-01 7.21e-01 0.13700 0.119000 0.068700 4.11e-01 6.34e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 13 6.19e-01 7.22e-01 0.16000 0.151000 -0.054800 3.47e-01 7.33e-01
Synthesis of PIPs at the Golgi membrane 12 6.25e-01 7.28e-01 0.16600 0.151000 -0.069600 3.66e-01 6.76e-01
Interconversion of nucleotide di- and triphosphates 22 6.27e-01 7.30e-01 0.12200 -0.114000 0.041100 3.53e-01 7.39e-01
Prefoldin mediated transfer of substrate to CCT/TriC 17 6.30e-01 7.32e-01 0.13100 0.123000 0.045100 3.79e-01 7.48e-01
Synthesis of glycosylphosphatidylinositol (GPI) 13 6.30e-01 7.32e-01 0.15700 -0.149000 0.049800 3.52e-01 7.56e-01
Regulation of FZD by ubiquitination 11 6.36e-01 7.38e-01 0.16100 -0.149000 -0.062500 3.94e-01 7.20e-01
Cell-Cell communication 46 6.37e-01 7.38e-01 0.08350 0.073400 -0.039700 3.90e-01 6.42e-01
Purine catabolism 11 6.40e-01 7.41e-01 0.17000 0.150000 -0.079500 3.90e-01 6.48e-01
IKK complex recruitment mediated by RIP1 17 6.42e-01 7.43e-01 0.12700 0.105000 0.071700 4.53e-01 6.09e-01
Interleukin-12 signaling 35 6.43e-01 7.43e-01 0.08850 0.069300 0.055100 4.79e-01 5.73e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 6.46e-01 7.46e-01 0.12900 -0.125000 0.031600 3.57e-01 8.17e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 16 6.47e-01 7.47e-01 0.13000 -0.094400 -0.089000 5.13e-01 5.38e-01
TNF signaling 36 6.52e-01 7.51e-01 0.09120 -0.032000 0.085400 7.40e-01 3.76e-01
Neurotransmitter release cycle 19 6.53e-01 7.52e-01 0.11900 -0.046700 -0.109000 7.25e-01 4.09e-01
Glyoxylate metabolism and glycine degradation 19 6.54e-01 7.52e-01 0.12400 -0.026800 0.121000 8.40e-01 3.62e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 26 6.55e-01 7.52e-01 0.10700 -0.095000 0.050100 4.02e-01 6.59e-01
Inactivation, recovery and regulation of the phototransduction cascade 15 6.57e-01 7.52e-01 0.13900 -0.135000 0.034100 3.67e-01 8.19e-01
The phototransduction cascade 15 6.57e-01 7.52e-01 0.13900 -0.135000 0.034100 3.67e-01 8.19e-01
Pausing and recovery of Tat-mediated HIV elongation 25 6.57e-01 7.52e-01 0.10700 -0.012800 0.106000 9.12e-01 3.60e-01
Tat-mediated HIV elongation arrest and recovery 25 6.57e-01 7.52e-01 0.10700 -0.012800 0.106000 9.12e-01 3.60e-01
TICAM1, RIP1-mediated IKK complex recruitment 17 6.60e-01 7.54e-01 0.12400 0.115000 0.047700 4.13e-01 7.34e-01
Cell junction organization 25 6.62e-01 7.56e-01 0.10900 0.073300 -0.080300 5.26e-01 4.88e-01
PERK regulates gene expression 26 6.63e-01 7.56e-01 0.09940 -0.052600 -0.084300 6.43e-01 4.57e-01
VEGFR2 mediated cell proliferation 16 6.65e-01 7.58e-01 0.13500 0.067200 -0.117000 6.42e-01 4.20e-01
Metabolism of nitric oxide: NOS3 activation and regulation 11 6.66e-01 7.58e-01 0.15300 0.053300 0.143000 7.60e-01 4.10e-01
Activation of BH3-only proteins 27 6.67e-01 7.58e-01 0.10200 0.098000 -0.028200 3.78e-01 8.00e-01
Mitochondrial biogenesis 50 6.68e-01 7.59e-01 0.07150 -0.026300 -0.066500 7.48e-01 4.17e-01
Senescence-Associated Secretory Phenotype (SASP) 41 6.70e-01 7.61e-01 0.07900 0.075600 0.022900 4.03e-01 8.00e-01
Glycolysis 57 6.78e-01 7.69e-01 0.06720 0.002740 0.067200 9.71e-01 3.81e-01
Downregulation of TGF-beta receptor signaling 26 6.82e-01 7.72e-01 0.09560 0.059400 0.074900 6.00e-01 5.09e-01
Neurexins and neuroligins 19 6.87e-01 7.77e-01 0.11300 -0.109000 -0.029200 4.12e-01 8.26e-01
Glucose metabolism 72 6.89e-01 7.77e-01 0.05680 0.043300 0.036800 5.26e-01 5.91e-01
Transcriptional activation of mitochondrial biogenesis 36 6.89e-01 7.77e-01 0.08060 -0.038400 -0.070800 6.91e-01 4.63e-01
Chaperone Mediated Autophagy 12 6.89e-01 7.77e-01 0.13900 -0.099700 -0.096300 5.50e-01 5.64e-01
SUMOylation of transcription factors 12 6.92e-01 7.79e-01 0.13800 0.105000 0.089700 5.30e-01 5.91e-01
DCC mediated attractive signaling 11 6.92e-01 7.80e-01 0.15300 -0.140000 0.062700 4.22e-01 7.19e-01
Mitotic Prometaphase 155 6.94e-01 7.81e-01 0.04060 -0.010200 0.039300 8.27e-01 4.01e-01
Cargo trafficking to the periciliary membrane 40 6.99e-01 7.84e-01 0.07460 -0.048900 -0.056400 5.93e-01 5.38e-01
TRAF3-dependent IRF activation pathway 13 6.99e-01 7.84e-01 0.13400 0.132000 0.023300 4.12e-01 8.84e-01
RAS processing 15 7.01e-01 7.85e-01 0.12300 -0.030800 -0.119000 8.36e-01 4.23e-01
Signaling by PDGFR in disease 16 7.01e-01 7.86e-01 0.11900 0.034700 0.114000 8.10e-01 4.31e-01
KSRP (KHSRP) binds and destabilizes mRNA 15 7.02e-01 7.86e-01 0.12100 -0.065300 -0.102000 6.62e-01 4.94e-01
Dopamine Neurotransmitter Release Cycle 12 7.03e-01 7.86e-01 0.13800 -0.137000 -0.016700 4.10e-01 9.20e-01
Base-Excision Repair, AP Site Formation 13 7.05e-01 7.87e-01 0.13400 -0.134000 0.004190 4.03e-01 9.79e-01
TP53 Regulates Transcription of Cell Death Genes 30 7.06e-01 7.88e-01 0.09120 0.070800 -0.057400 5.02e-01 5.87e-01
Metal ion SLC transporters 15 7.08e-01 7.90e-01 0.12700 0.118000 -0.046700 4.30e-01 7.54e-01
Attenuation phase 19 7.10e-01 7.90e-01 0.10700 0.098500 0.041100 4.58e-01 7.56e-01
CD209 (DC-SIGN) signaling 15 7.10e-01 7.90e-01 0.12100 0.119000 0.024900 4.26e-01 8.67e-01
Branched-chain amino acid catabolism 19 7.15e-01 7.95e-01 0.11200 -0.069500 0.088300 6.00e-01 5.06e-01
Aggrephagy 18 7.18e-01 7.97e-01 0.11000 0.109000 0.009840 4.22e-01 9.42e-01
Vitamin B5 (pantothenate) metabolism 11 7.45e-01 8.26e-01 0.12900 0.115000 0.060200 5.11e-01 7.30e-01
Condensation of Prometaphase Chromosomes 10 7.45e-01 8.26e-01 0.13800 0.134000 0.029500 4.62e-01 8.72e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 26 7.48e-01 8.28e-01 0.08490 -0.083000 -0.017900 4.64e-01 8.74e-01
Resolution of D-Loop Structures 27 7.49e-01 8.28e-01 0.08660 -0.080200 0.032700 4.71e-01 7.69e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 10 7.49e-01 8.28e-01 0.14100 0.040000 -0.135000 8.27e-01 4.58e-01
Chondroitin sulfate/dermatan sulfate metabolism 26 7.51e-01 8.28e-01 0.08870 0.049500 -0.073600 6.62e-01 5.16e-01
Interleukin-35 Signalling 11 7.54e-01 8.31e-01 0.13500 -0.110000 0.079300 5.29e-01 6.49e-01
Syndecan interactions 10 7.55e-01 8.32e-01 0.14000 0.131000 -0.048700 4.73e-01 7.90e-01
N-glycan antennae elongation in the medial/trans-Golgi 17 7.56e-01 8.32e-01 0.10300 0.098500 0.028600 4.82e-01 8.38e-01
CDC6 association with the ORC:origin complex 10 7.59e-01 8.34e-01 0.13900 -0.056200 0.127000 7.58e-01 4.85e-01
DNA Damage/Telomere Stress Induced Senescence 23 7.61e-01 8.35e-01 0.08960 -0.008960 0.089100 9.41e-01 4.60e-01
Transcriptional Regulation by VENTX 30 7.61e-01 8.35e-01 0.07960 -0.025700 0.075300 8.07e-01 4.76e-01
TNFR1-induced NFkappaB signaling pathway 19 7.62e-01 8.35e-01 0.09900 -0.097000 0.019500 4.64e-01 8.83e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 62 7.63e-01 8.35e-01 0.05420 0.054100 -0.003200 4.62e-01 9.65e-01
Mitotic Prophase 73 7.64e-01 8.35e-01 0.05130 -0.025500 0.044600 7.08e-01 5.11e-01
Metabolic disorders of biological oxidation enzymes 14 7.70e-01 8.40e-01 0.11600 0.087900 -0.075300 5.69e-01 6.26e-01
DNA Damage Recognition in GG-NER 35 7.70e-01 8.40e-01 0.07260 -0.066200 0.029700 4.98e-01 7.62e-01
Negative regulators of DDX58/IFIH1 signaling 33 7.76e-01 8.46e-01 0.07420 -0.044300 0.059400 6.60e-01 5.55e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 55 7.77e-01 8.46e-01 0.05350 0.033100 0.042000 6.71e-01 5.91e-01
Signaling by KIT in disease 17 7.79e-01 8.47e-01 0.09850 0.003860 0.098400 9.78e-01 4.83e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 17 7.79e-01 8.47e-01 0.09850 0.003860 0.098400 9.78e-01 4.83e-01
APC/C:Cdc20 mediated degradation of Cyclin B 22 7.83e-01 8.50e-01 0.08580 -0.085800 -0.002300 4.86e-01 9.85e-01
HSF1-dependent transactivation 25 7.84e-01 8.50e-01 0.07780 0.041800 0.065700 7.18e-01 5.70e-01
Regulation of TP53 Degradation 32 7.85e-01 8.50e-01 0.07330 -0.064800 0.034200 5.26e-01 7.38e-01
Regulation of RUNX1 Expression and Activity 15 7.85e-01 8.50e-01 0.10200 0.022700 0.099400 8.79e-01 5.05e-01
Nephrin family interactions 13 7.89e-01 8.54e-01 0.11300 -0.104000 0.044600 5.16e-01 7.81e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 23 7.92e-01 8.55e-01 0.08410 -0.079500 0.027300 5.09e-01 8.21e-01
mRNA decay by 5' to 3' exoribonuclease 15 7.92e-01 8.55e-01 0.09910 -0.091400 -0.038300 5.40e-01 7.98e-01
Regulation of TP53 Expression and Degradation 33 7.92e-01 8.55e-01 0.07020 -0.066200 0.023400 5.11e-01 8.16e-01
N-Glycan antennae elongation 11 7.94e-01 8.56e-01 0.11600 0.112000 0.029200 5.20e-01 8.67e-01
RHO GTPases Activate Formins 100 7.94e-01 8.56e-01 0.03800 0.031100 0.021800 5.92e-01 7.07e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 16 8.04e-01 8.65e-01 0.09310 -0.030100 -0.088100 8.35e-01 5.42e-01
Pyruvate metabolism 20 8.06e-01 8.66e-01 0.08180 0.053800 0.061600 6.77e-01 6.34e-01
IRS-related events triggered by IGF1R 22 8.08e-01 8.68e-01 0.08290 -0.042600 0.071100 7.29e-01 5.64e-01
Transport of vitamins, nucleosides, and related molecules 21 8.13e-01 8.72e-01 0.08420 0.056600 -0.062300 6.53e-01 6.22e-01
Regulation of PLK1 Activity at G2/M Transition 74 8.15e-01 8.73e-01 0.04160 0.033500 0.024600 6.19e-01 7.15e-01
Maturation of nucleoprotein 10 8.19e-01 8.77e-01 0.11300 0.036100 0.107000 8.43e-01 5.59e-01
Regulation of pyruvate dehydrogenase (PDH) complex 11 8.24e-01 8.81e-01 0.11200 -0.077100 0.081700 6.58e-01 6.39e-01
Meiotic synapsis 23 8.25e-01 8.81e-01 0.07280 -0.067000 -0.028400 5.78e-01 8.14e-01
Regulation of necroptotic cell death 11 8.30e-01 8.85e-01 0.10900 -0.049100 0.097900 7.78e-01 5.74e-01
IGF1R signaling cascade 23 8.31e-01 8.85e-01 0.07360 -0.006360 0.073300 9.58e-01 5.43e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 23 8.31e-01 8.85e-01 0.07360 -0.006360 0.073300 9.58e-01 5.43e-01
Kinesins 31 8.32e-01 8.85e-01 0.06150 0.058200 0.019800 5.75e-01 8.49e-01
Signaling by FGFR2 47 8.32e-01 8.85e-01 0.04950 0.042100 0.026000 6.18e-01 7.58e-01
Nicotinamide salvaging 11 8.35e-01 8.86e-01 0.10400 0.103000 0.009360 5.53e-01 9.57e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 15 8.35e-01 8.86e-01 0.09120 -0.087600 0.025100 5.57e-01 8.67e-01
Caspase activation via Death Receptors in the presence of ligand 10 8.39e-01 8.89e-01 0.11200 0.094800 -0.059200 6.04e-01 7.46e-01
STING mediated induction of host immune responses 10 8.39e-01 8.89e-01 0.10800 0.108000 -0.003990 5.54e-01 9.83e-01
Basigin interactions 14 8.39e-01 8.89e-01 0.09390 0.040900 -0.084600 7.91e-01 5.84e-01
Mitochondrial calcium ion transport 18 8.42e-01 8.89e-01 0.07840 0.019800 0.075800 8.84e-01 5.78e-01
Metabolism of folate and pterines 11 8.42e-01 8.89e-01 0.09880 0.084100 0.051800 6.29e-01 7.66e-01
Methylation 10 8.42e-01 8.89e-01 0.11000 -0.101000 0.043300 5.81e-01 8.13e-01
Phosphorylation of the APC/C 18 8.43e-01 8.90e-01 0.07970 -0.079500 0.004940 5.60e-01 9.71e-01
Netrin-1 signaling 25 8.45e-01 8.90e-01 0.06940 -0.058300 0.037600 6.14e-01 7.45e-01
Potassium Channels 25 8.55e-01 9.00e-01 0.06600 0.063300 -0.018400 5.84e-01 8.73e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 37 8.56e-01 9.00e-01 0.05460 0.026000 -0.048000 7.84e-01 6.14e-01
NRIF signals cell death from the nucleus 14 8.58e-01 9.02e-01 0.08840 0.070300 -0.053500 6.49e-01 7.29e-01
Cleavage of the damaged pyrimidine 12 8.61e-01 9.02e-01 0.08860 -0.080900 -0.036100 6.27e-01 8.28e-01
Depyrimidination 12 8.61e-01 9.02e-01 0.08860 -0.080900 -0.036100 6.27e-01 8.28e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 12 8.61e-01 9.02e-01 0.08860 -0.080900 -0.036100 6.27e-01 8.28e-01
Processing of SMDT1 12 8.69e-01 9.10e-01 0.08560 0.038500 0.076400 8.17e-01 6.47e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 19 8.75e-01 9.15e-01 0.06710 0.016800 0.065000 8.99e-01 6.24e-01
Signaling by ERBB2 ECD mutants 10 8.77e-01 9.16e-01 0.09710 -0.069600 0.067700 7.03e-01 7.11e-01
Nonhomologous End-Joining (NHEJ) 28 8.78e-01 9.17e-01 0.05580 -0.003630 0.055700 9.74e-01 6.10e-01
HSF1 activation 21 8.81e-01 9.18e-01 0.06570 -0.053800 0.037700 6.70e-01 7.65e-01
Metabolism of water-soluble vitamins and cofactors 79 8.81e-01 9.18e-01 0.03210 0.010200 0.030400 8.76e-01 6.41e-01
Endosomal/Vacuolar pathway 11 8.84e-01 9.19e-01 0.08390 -0.038900 -0.074400 8.23e-01 6.69e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 12 8.84e-01 9.19e-01 0.08100 0.023600 0.077500 8.87e-01 6.42e-01
Other interleukin signaling 15 8.89e-01 9.23e-01 0.07010 0.060300 0.035800 6.86e-01 8.11e-01
Signaling by EGFR in Cancer 16 8.90e-01 9.24e-01 0.07100 0.068300 -0.019400 6.36e-01 8.93e-01
Integrin cell surface interactions 25 8.97e-01 9.30e-01 0.05210 0.043000 0.029400 7.10e-01 7.99e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 22 9.00e-01 9.32e-01 0.05510 -0.051500 -0.019700 6.76e-01 8.73e-01
Visual phototransduction 30 9.00e-01 9.32e-01 0.04940 -0.016600 0.046600 8.75e-01 6.59e-01
Mitochondrial Fatty Acid Beta-Oxidation 25 9.01e-01 9.32e-01 0.05240 -0.052100 -0.004630 6.52e-01 9.68e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 18 9.02e-01 9.32e-01 0.06080 -0.059200 -0.014000 6.64e-01 9.18e-01
p75NTR signals via NF-kB 11 9.03e-01 9.32e-01 0.08040 0.028300 -0.075300 8.71e-01 6.66e-01
Signaling by ERBB2 in Cancer 12 9.05e-01 9.33e-01 0.07550 0.013700 -0.074300 9.35e-01 6.56e-01
Mitotic Spindle Checkpoint 96 9.10e-01 9.37e-01 0.02550 -0.025200 -0.003650 6.71e-01 9.51e-01
FOXO-mediated transcription of cell cycle genes 13 9.16e-01 9.42e-01 0.06750 -0.067000 0.008050 6.76e-01 9.60e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 16 9.17e-01 9.42e-01 0.05980 0.059600 0.003710 6.80e-01 9.80e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 16 9.17e-01 9.42e-01 0.05980 0.059600 0.003710 6.80e-01 9.80e-01
Pexophagy 10 9.26e-01 9.51e-01 0.07400 0.056600 -0.047600 7.57e-01 7.94e-01
Long-term potentiation 10 9.28e-01 9.52e-01 0.07220 -0.068000 0.024000 7.10e-01 8.95e-01
Regulation of innate immune responses to cytosolic DNA 12 9.29e-01 9.52e-01 0.06580 -0.028300 0.059400 8.65e-01 7.22e-01
Miscellaneous transport and binding events 14 9.43e-01 9.66e-01 0.05200 -0.051300 -0.008200 7.40e-01 9.58e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 11 9.44e-01 9.66e-01 0.05710 -0.027000 -0.050300 8.77e-01 7.73e-01
Association of TriC/CCT with target proteins during biosynthesis 29 9.49e-01 9.70e-01 0.03590 -0.028000 0.022500 7.95e-01 8.34e-01
Signaling by ERBB2 KD Mutants 11 9.55e-01 9.74e-01 0.05190 -0.050900 -0.009950 7.70e-01 9.54e-01
Non-integrin membrane-ECM interactions 14 9.55e-01 9.74e-01 0.04790 0.020600 -0.043200 8.94e-01 7.80e-01
Constitutive Signaling by EGFRvIII 10 9.57e-01 9.74e-01 0.05420 0.054200 -0.000129 7.67e-01 9.99e-01
Signaling by EGFRvIII in Cancer 10 9.57e-01 9.74e-01 0.05420 0.054200 -0.000129 7.67e-01 9.99e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 33 9.61e-01 9.77e-01 0.02850 -0.028200 0.004120 7.79e-01 9.67e-01
Diseases of mitotic cell cycle 33 9.61e-01 9.77e-01 0.02850 -0.028200 0.004120 7.79e-01 9.67e-01
Purine salvage 11 9.68e-01 9.83e-01 0.04350 0.041800 0.012200 8.11e-01 9.44e-01
Metabolism of nucleotides 69 9.71e-01 9.85e-01 0.01730 -0.015700 0.007400 8.22e-01 9.15e-01
Resolution of Sister Chromatid Cohesion 90 9.72e-01 9.85e-01 0.01420 -0.011300 -0.008580 8.54e-01 8.88e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 10 9.73e-01 9.86e-01 0.04390 -0.036300 0.024700 8.43e-01 8.93e-01
Mitochondrial iron-sulfur cluster biogenesis 10 9.77e-01 9.88e-01 0.03810 -0.027700 -0.026100 8.79e-01 8.86e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 81 9.82e-01 9.91e-01 0.01190 -0.008140 -0.008620 8.99e-01 8.94e-01
Amplification of signal from the kinetochores 81 9.82e-01 9.91e-01 0.01190 -0.008140 -0.008620 8.99e-01 8.94e-01
Protein methylation 12 9.83e-01 9.91e-01 0.03070 0.006700 0.029900 9.68e-01 8.58e-01
Cyclin D associated events in G1 41 9.91e-01 9.98e-01 0.01240 0.002550 -0.012200 9.78e-01 8.93e-01
G1 Phase 41 9.91e-01 9.98e-01 0.01240 0.002550 -0.012200 9.78e-01 8.93e-01
Downstream signaling of activated FGFR1 12 9.96e-01 9.99e-01 0.01470 0.001690 -0.014600 9.92e-01 9.30e-01
Downstream signaling of activated FGFR2 12 9.96e-01 9.99e-01 0.01470 0.001690 -0.014600 9.92e-01 9.30e-01
Downstream signaling of activated FGFR3 12 9.96e-01 9.99e-01 0.01470 0.001690 -0.014600 9.92e-01 9.30e-01
Downstream signaling of activated FGFR4 12 9.96e-01 9.99e-01 0.01470 0.001690 -0.014600 9.92e-01 9.30e-01
EML4 and NUDC in mitotic spindle formation 85 9.97e-01 9.99e-01 0.00494 0.002430 0.004300 9.69e-01 9.46e-01
SUMOylation of transcription cofactors 35 9.99e-01 1.00e+00 0.00322 -0.001120 0.003020 9.91e-01 9.75e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 14 1.00e+00 1.00e+00 0.00395 0.001960 0.003440 9.90e-01 9.82e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 14 1.00e+00 1.00e+00 0.00395 0.001960 0.003440 9.90e-01 9.82e-01


Detailed Gene set reports


Neutrophil degranulation

Neutrophil degranulation
metric value
setSize 306
pMANOVA 1.49e-50
p.adjustMANOVA 1.66e-47
s.dist 0.509
s.RNA 0.505
s.meth -0.0657
p.RNA 1.13e-51
p.meth 0.0503




Top 20 genes
Gene RNA meth
P2RX1 4648 -1949
UNC13D 4542 -1906
TRPM2 4469 -1794
CTSZ 4030 -1980
CD300A 3868 -2000
PYCARD 4187 -1820
CYSTM1 4340 -1742
C3AR1 4610 -1596
TYROBP 3657 -1997
ATP6V0A1 4546 -1571
MNDA 3547 -1996
NAPRT 3692 -1871
IGF2R 4158 -1659
SERPINB1 4584 -1479
SLC15A4 4272 -1577
AGPAT2 4525 -1388
QPCT 4247 -1474
VAT1 4521 -1359
ARSB 4014 -1528
LAMTOR1 3714 -1589

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -376 567
ACAA1 4343 5790
ACLY 4076 2976
ACTR10 2879 4868
ACTR1B -2740 2629
ACTR2 3672 3844
ADAM10 4095 2760
ADAM8 2913 5097
ADGRE5 3420 -1470
AGA -1464 2162
AGL -165 1016
AGPAT2 4525 -1388
ALAD 4020 1057
ALDOA 4426 5367
ALDOC -2432 65
ALOX5 4460 5386
AMPD3 3980 3216
ANO6 1978 1102
AP1M1 3701 1777
APAF1 3421 -809
APEH 1920 832
APRT -2907 2643
ARHGAP9 2946 6257
ARL8A 4001 -1058
ARMC8 1704 2641
ARPC5 4209 2611
ARSA 2606 523
ARSB 4014 -1528
ASAH1 4412 2174
ATAD3B -3760 4811
ATG7 2429 3847
ATP11A 4198 132
ATP11B 2964 -241
ATP6V0A1 4546 -1571
ATP6V0C 4483 2933
ATP6V1D 4067 1096
ATP8A1 -4193 -913
ATP8B4 2620 -1100
B2M -2207 -9
B4GALT1 3113 7043
BIN2 3741 5390
BRI3 4445 -1178
BST2 -306 -1935
C3AR1 4610 -1596
C6orf120 1825 3829
CAB39 3640 7109
CAND1 -2920 2163
CAP1 3919 2034
CAPN1 4333 1819
CAT 4134 -1206
CCT2 -4539 194
CCT8 -92 2904
CD300A 3868 -2000
CD44 3690 4898
CD47 -4015 6603
CD53 4111 6484
CD55 4493 1455
CD58 3673 -611
CD59 1662 -1684
CD63 4635 5434
CDK13 436 5779
CEACAM1 2004 5459
CEP290 -3173 7002
CKAP4 4383 -987
CMTM6 3768 1926
CNN2 2979 -418
COMMD3 -955 -1962
COMMD9 2968 2239
COPB1 3055 2637
COTL1 4275 6761
CPNE1 -985 5132
CPNE3 1782 -1443
CPPED1 3977 -641
CREG1 3715 -1060
CSNK2B 1983 4743
CSTB 3694 2893
CTSA 4474 2720
CTSB 4614 -965
CTSC 3824 1311
CTSD 4618 6622
CTSS 2705 -1546
CTSZ 4030 -1980
CYB5R3 4411 3239
CYBA 4037 2019
CYFIP1 4176 256
CYSTM1 4340 -1742
DBNL 3658 -406
DEGS1 1764 3203
DERA 3865 3602
DGAT1 1176 -576
DIAPH1 2862 2371
DNAJC13 3911 408
DNAJC3 3890 6472
DNAJC5 4183 -1398
DPP7 -2342 6586
DSN1 -1681 -997
DYNC1H1 416 4434
DYNC1LI1 3337 3242
DYNLL1 1152 5151
DYNLT1 2448 5601
EEF1A1 -4143 2941
EEF2 -2045 4196
ENPP4 -162 3170
ERP44 2444 920
FABP5 2835 2233
FAF2 2633 2842
FGR 4616 -1075
FTH1 2313 3117
FTL 4047 -1426
FUCA1 2386 1656
FUCA2 2692 -1236
GAA 3199 2768
GALNS 3231 3670
GCA 4476 5561
GDI2 2972 3343
GGH 3052 3861
GHDC 552 -571
GLB1 4153 1828
GLIPR1 1534 5593
GM2A 4470 6363
GMFG 3664 6369
GNS 4646 4429
GOLGA7 648 3104
GPI 3145 5674
GRN 4424 4938
GSDMD -146 -91
GSTP1 433 -1352
GUSB 4577 2338
GYG1 4447 -231
HEBP2 2475 552
HEXB 3333 2906
HGSNAT 472 3342
HLA-A -2315 -1094
HLA-B 157 -730
HLA-C 725 4449
HLA-H -726 4989
HMGB1 -1409 3222
HMOX2 -3777 6413
HSP90AA1 -729 6210
HSP90AB1 -4016 -1226
HSPA1A 3351 -920
HSPA1B 2487 655
HVCN1 -239 -385
IDH1 4649 3454
IGF2R 4158 -1659
ILF2 -1315 2770
IMPDH1 4587 2600
IMPDH2 -4613 250
IQGAP1 4024 587
IQGAP2 3573 3888
IST1 3188 1014
ITGAL 761 7038
ITGAV 2675 -370
ITGB2 4462 6426
KCMF1 3303 3310
KCNAB2 2568 -600
KPNB1 1964 1140
LAIR1 4508 3425
LAMP1 3979 2553
LAMTOR1 3714 -1589
LAMTOR2 3191 -1342
LAMTOR3 2265 957
LPCAT1 2522 1418
LRMP 1482 -296
LTA4H 4283 798
MAN2B1 2177 6389
MANBA 2899 6846
MAPK1 4560 6099
MAPK14 4478 2465
MIF -2780 3355
MLEC 526 2183
MMP25 4294 6854
MNDA 3547 -1996
MPO -1063 -1969
MVP 3194 6955
NAPRT 3692 -1871
NBEAL2 3989 1726
NCKAP1L 4619 -320
NCSTN 4654 1224
NDUFC2 2185 2881
NEU1 4492 1899
NHLRC3 1939 4506
NIT2 -4036 -141
NME2 9 -880
NPC2 1910 2198
ORMDL3 -2693 3085
OSCAR 4628 7123
OSTF1 3412 6470
P2RX1 4648 -1949
PA2G4 -1614 5243
PAFAH1B2 2581 2435
PDAP1 3353 2952
PDXK 3330 1492
PFKL -1392 -1732
PGAM1 4549 1307
PGM1 2618 776
PGM2 4264 5134
PKM 4341 3231
PLAC8 4527 1235
PLAU 1259 -1529
PLAUR 4124 -861
PLD1 4582 -902
PLEKHO2 4455 6699
PNP 2649 3516
PPIA -1958 4555
PPIE -2923 6027
PRCP 3614 611
PRDX6 2308 5478
PRKCD 4519 6360
PRTN3 -1895 5621
PSAP 3637 628
PSEN1 4223 4955
PSMA2 407 5164
PSMA5 -2322 3319
PSMB1 -556 5410
PSMB7 3355 4199
PSMC3 735 736
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD6 2590 2336
PSMD7 1576 2079
PTGES2 -2631 -901
PTPN6 4000 6542
PTPRC 2525 -936
PTPRJ 4193 7170
PTPRN2 1186 6585
PYCARD 4187 -1820
PYGB -3 141
QPCT 4247 -1474
QSOX1 4636 5727
RAB10 4485 3067
RAB14 2619 -378
RAB18 2483 2764
RAB24 3244 -168
RAB27A 3787 222
RAB37 -885 409
RAB3A 2502 4348
RAB3D 4330 1148
RAB4B 3084 4688
RAB5B 3004 1957
RAB5C 3866 797
RAB6A 3957 3323
RAB7A 4110 -124
RAC1 4404 5541
RAP1A 3123 6569
RAP1B 3135 5968
RAP2B 1744 5292
RHOA 3965 4033
RHOF -3727 6478
RHOG 4253 3664
RNASET2 3046 7090
ROCK1 3502 2732
S100A11 4403 6089
S100P 3960 3303
SCAMP1 -1690 2645
SDCBP 3944 3834
SERPINB1 4584 -1479
SERPINB6 2494 2823
SLC11A1 4657 4001
SLC15A4 4272 -1577
SLC27A2 -1491 -1411
SLC2A3 4329 -1211
SLC44A2 1805 4323
SLCO4C1 3222 -99
SNAP23 3209 -471
SNAP29 3729 3148
SPTAN1 -4215 -407
SRP14 2428 5764
STBD1 2421 -658
STK10 3259 -688
STK11IP 2803 2122
STOM 3315 -1586
SURF4 3260 3679
SVIP -231 1104
TBC1D10C -3594 6912
TCIRG1 4397 1353
TLR2 4229 4128
TMBIM1 4011 -47
TMC6 -3143 6750
TMEM179B -174 5597
TMEM30A 2939 6660
TMEM63A -3975 2620
TNFRSF1B 4053 6870
TOLLIP 3698 664
TOM1 4334 4280
TRAPPC1 3635 5233
TRPM2 4469 -1794
TSPAN14 4336 4963
TUBB -532 6248
TUBB4B 2796 7163
TXNDC5 -1496 -1873
TYROBP 3657 -1997
UNC13D 4542 -1906
VAMP8 592 868
VAPA 3892 4246
VAT1 4521 -1359
VCL 2594 3614
VCP 3034 1908
XRCC5 1586 1327
XRCC6 -2304 3282
YPEL5 2436 3986



Innate Immune System

Innate Immune System
metric value
setSize 617
pMANOVA 2.85e-45
p.adjustMANOVA 1.59e-42
s.dist 0.342
s.RNA 0.342
s.meth -0.000106
p.RNA 2.74e-46
p.meth 0.996




Top 20 genes
Gene RNA meth
P2RX1 4648 -1949
UNC13D 4542 -1906
RPS6KA1 4497 -1859
NCF4 4148 -1941
TRPM2 4469 -1794
CTSZ 4030 -1980
CD300A 3868 -2000
PYCARD 4187 -1820
CYSTM1 4340 -1742
C3AR1 4610 -1596
TYROBP 3657 -1997
LAT2 4233 -1716
RNF135 4465 -1615
ATP6V0A1 4546 -1571
MNDA 3547 -1996
NAPRT 3692 -1871
IGF2R 4158 -1659
SERPINB1 4584 -1479
SLC15A4 4272 -1577
TXN 3643 -1735

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -376 567
AAMP -2190 7121
ABI1 3644 3253
ABI2 -3635 -206
ABL1 1975 2469
ACAA1 4343 5790
ACLY 4076 2976
ACTB 4359 5447
ACTG1 3825 1603
ACTR10 2879 4868
ACTR1B -2740 2629
ACTR2 3672 3844
ACTR3 3554 5952
ADAM10 4095 2760
ADAM8 2913 5097
ADGRE5 3420 -1470
AGA -1464 2162
AGL -165 1016
AGPAT2 4525 -1388
AHCYL1 2934 2692
AIM2 -573 -1277
ALAD 4020 1057
ALDOA 4426 5367
ALDOC -2432 65
ALOX5 4460 5386
AMPD3 3980 3216
ANO6 1978 1102
AP1M1 3701 1777
APAF1 3421 -809
APEH 1920 832
APP 2952 6623
APRT -2907 2643
ARHGAP9 2946 6257
ARL8A 4001 -1058
ARMC8 1704 2641
ARPC1B 4422 1709
ARPC2 3659 2292
ARPC3 3630 3208
ARPC5 4209 2611
ARSA 2606 523
ARSB 4014 -1528
ASAH1 4412 2174
ATAD3B -3760 4811
ATF1 1229 2989
ATG12 -1943 6823
ATG5 -502 -680
ATG7 2429 3847
ATOX1 2731 390
ATP11A 4198 132
ATP11B 2964 -241
ATP6V0A1 4546 -1571
ATP6V0A2 -2629 6653
ATP6V0B 3723 5503
ATP6V0C 4483 2933
ATP6V0D1 4488 6936
ATP6V0E1 3450 1836
ATP6V0E2 -4253 -1327
ATP6V1A 3956 -1497
ATP6V1B2 3836 -1555
ATP6V1C1 3831 6759
ATP6V1D 4067 1096
ATP6V1E1 3280 4776
ATP6V1F 1531 -699
ATP6V1G2 -4149 3740
ATP6V1H 3287 2559
ATP8A1 -4193 -913
ATP8B4 2620 -1100
B2M -2207 -9
B4GALT1 3113 7043
BAIAP2 -1012 2757
BCL10 2493 2575
BCL2 -3030 7022
BCL2L1 1477 5970
BIN2 3741 5390
BIRC2 511 6626
BIRC3 -4591 4817
BRI3 4445 -1178
BRK1 1195 3071
BST2 -306 -1935
BTRC -1864 -923
C3AR1 4610 -1596
C6orf120 1825 3829
C8G -1547 -1366
CAB39 3640 7109
CALM1 263 4502
CAND1 -2920 2163
CAP1 3919 2034
CAPN1 4333 1819
CAPZA1 3861 999
CAPZA2 3520 4667
CARD11 -4025 6544
CARD9 2714 -1763
CASP1 1192 7031
CASP10 216 -1807
CASP4 2046 -96
CASP8 -1893 5448
CASP9 4537 3202
CAT 4134 -1206
CCT2 -4539 194
CCT8 -92 2904
CD247 -3684 6036
CD300A 3868 -2000
CD4 -2816 909
CD44 3690 4898
CD46 1453 5540
CD47 -4015 6603
CD53 4111 6484
CD55 4493 1455
CD58 3673 -611
CD59 1662 -1684
CD63 4635 5434
CD81 -1239 3296
CDC34 3770 -408
CDC42 3449 856
CDK13 436 5779
CEACAM1 2004 5459
CEP290 -3173 7002
CFL1 3970 1646
CHUK 3354 1111
CKAP4 4383 -987
CMTM6 3768 1926
CNN2 2979 -418
CNPY3 2764 1242
COMMD3 -955 -1962
COMMD9 2968 2239
COPB1 3055 2637
COTL1 4275 6761
CPNE1 -985 5132
CPNE3 1782 -1443
CPPED1 3977 -641
CRCP 2844 4708
CREB1 -1458 1422
CREBBP 2340 892
CREG1 3715 -1060
CRK 4199 6598
CSNK2B 1983 4743
CSTB 3694 2893
CTNNB1 3473 5070
CTSA 4474 2720
CTSB 4614 -965
CTSC 3824 1311
CTSD 4618 6622
CTSL 4277 3028
CTSS 2705 -1546
CTSV -1816 5170
CTSZ 4030 -1980
CUL1 -4005 -1192
CYB5R3 4411 3239
CYBA 4037 2019
CYFIP1 4176 256
CYFIP2 -1121 6159
CYLD -4559 5706
CYSTM1 4340 -1742
DBNL 3658 -406
DDX41 568 4426
DDX58 -3438 185
DEGS1 1764 3203
DERA 3865 3602
DGAT1 1176 -576
DHX36 -922 6440
DHX58 -1608 -30
DHX9 -1320 5547
DIAPH1 2862 2371
DNAJC13 3911 408
DNAJC3 3890 6472
DNAJC5 4183 -1398
DNM1 2517 1607
DNM2 3828 3063
DPP7 -2342 6586
DSN1 -1681 -997
DTX4 3109 5144
DUSP3 2975 2260
DUSP4 -384 2494
DUSP6 -702 -1943
DUSP7 -732 722
DYNC1H1 416 4434
DYNC1LI1 3337 3242
DYNLL1 1152 5151
DYNLT1 2448 5601
ECSIT 954 1450
EEA1 503 5335
EEF1A1 -4143 2941
EEF2 -2045 4196
ELMO1 1982 939
ELMO2 4026 6110
ENPP4 -162 3170
EP300 3478 4901
ERP44 2444 920
FABP5 2835 2233
FADD 3156 -329
FAF2 2633 2842
FBXW11 2170 -1508
FGR 4616 -1075
FOS 692 5647
FTH1 2313 3117
FTL 4047 -1426
FUCA1 2386 1656
FUCA2 2692 -1236
FYN -1686 2793
GAA 3199 2768
GAB2 4007 2390
GALNS 3231 3670
GCA 4476 5561
GDI2 2972 3343
GGH 3052 3861
GHDC 552 -571
GLB1 4153 1828
GLIPR1 1534 5593
GM2A 4470 6363
GMFG 3664 6369
GNS 4646 4429
GOLGA7 648 3104
GPI 3145 5674
GRAP2 -265 3631
GRB2 4420 6241
GRN 4424 4938
GSDMD -146 -91
GSTP1 433 -1352
GUSB 4577 2338
GYG1 4447 -231
GZMM -2941 7252
HEBP2 2475 552
HERC5 -2560 -1038
HEXB 3333 2906
HGSNAT 472 3342
HLA-A -2315 -1094
HLA-B 157 -730
HLA-C 725 4449
HLA-E 766 5636
HLA-H -726 4989
HMGB1 -1409 3222
HMOX2 -3777 6413
HRAS -2340 -823
HSP90AA1 -729 6210
HSP90AB1 -4016 -1226
HSP90B1 -436 2127
HSPA1A 3351 -920
HSPA1B 2487 655
HVCN1 -239 -385
ICAM2 -4307 4819
ICAM3 2236 6840
IDH1 4649 3454
IFIH1 -2787 2681
IGF2R 4158 -1659
IKBKB -510 -912
IKBKE 2509 6705
ILF2 -1315 2770
IMPDH1 4587 2600
IMPDH2 -4613 250
IQGAP1 4024 587
IQGAP2 3573 3888
IRAK2 -1227 4686
IRAK3 4491 666
IRF3 -2846 4241
IRF7 856 3556
ISG15 -2022 6541
IST1 3188 1014
ITCH 2362 4854
ITGAL 761 7038
ITGAV 2675 -370
ITGB2 4462 6426
ITK -4418 -1701
ITPR1 -1851 1789
ITPR2 2474 -44
ITPR3 -2973 2189
JUN -400 1283
KCMF1 3303 3310
KCNAB2 2568 -600
KPNB1 1964 1140
KRAS 2245 3139
LAIR1 4508 3425
LAMP1 3979 2553
LAMTOR1 3714 -1589
LAMTOR2 3191 -1342
LAMTOR3 2265 957
LAT2 4233 -1716
LCK -4408 7246
LCP2 1073 -428
LGMN -2658 2706
LIMK1 3007 -1750
LPCAT1 2522 1418
LRMP 1482 -296
LRRFIP1 3688 5297
LTA4H 4283 798
MALT1 -4594 2545
MAN2B1 2177 6389
MANBA 2899 6846
MAP2K1 4239 1533
MAP2K3 4152 2411
MAP2K4 2698 4764
MAP2K6 4437 4792
MAP2K7 -54 1764
MAP3K1 2034 2247
MAP3K14 -4023 4221
MAP3K7 1566 -147
MAP3K8 4603 3266
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
MAPK7 3610 -244
MAPK8 -3916 4554
MAPK9 -1532 157
MAPKAPK2 3498 3265
MAPKAPK3 4597 2896
MAVS 2866 4281
MEF2A 3826 3013
MIF -2780 3355
MLEC 526 2183
MMP25 4294 6854
MNDA 3547 -1996
MPO -1063 -1969
MUC1 1680 6715
MUC12 -806 4641
MUC5B 2049 -1745
MVP 3194 6955
MYD88 4594 1945
MYH9 3463 6146
MYO9B 4114 6777
NAPRT 3692 -1871
NBEAL2 3989 1726
NCF4 4148 -1941
NCK1 -3877 1018
NCKAP1L 4619 -320
NCKIPSD -1667 667
NCSTN 4654 1224
NDUFC2 2185 2881
NEU1 4492 1899
NF2 1372 1410
NFATC1 -2143 6947
NFATC2 -3732 7159
NFATC3 -2782 1668
NFKB2 -2276 5251
NFKBIA 1525 6814
NFKBIB 2303 5574
NHLRC3 1939 4506
NIT2 -4036 -141
NKIRAS1 -1505 348
NKIRAS2 4544 -1132
NLRC5 -1747 1905
NLRP1 -2338 3033
NLRP3 3568 -847
NLRX1 4202 768
NME2 9 -880
NOD1 -1776 -321
NOD2 3807 6610
NOS3 -3550 4048
NPC2 1910 2198
ORMDL3 -2693 3085
OSCAR 4628 7123
OSTF1 3412 6470
P2RX1 4648 -1949
PA2G4 -1614 5243
PAFAH1B2 2581 2435
PAK1 3814 2452
PAK2 3574 283
PANX1 3249 3960
PCBP2 2 3201
PDAP1 3353 2952
PDPK1 3218 346
PDXK 3330 1492
PELI1 1886 1867
PELI2 2557 7035
PELI3 3582 -1123
PFKL -1392 -1732
PGAM1 4549 1307
PGM1 2618 776
PGM2 4264 5134
PIK3CA 946 1470
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R4 -1326 2170
PIN1 -43 4014
PKM 4341 3231
PLA2G6 -3342 826
PLAC8 4527 1235
PLAU 1259 -1529
PLAUR 4124 -861
PLCG1 -4367 958
PLCG2 3848 2803
PLD1 4582 -902
PLD3 2082 354
PLEKHO2 4455 6699
PNP 2649 3516
POLR1C -4305 5329
POLR1D 1066 6782
POLR2E 2119 3712
POLR2F 1375 509
POLR2H -2765 6299
POLR2K -1277 3853
POLR3A -15 5226
POLR3C -1330 3978
POLR3D -4218 1967
POLR3E -4103 1113
POLR3F -2735 -1023
POLR3G -1938 6661
POLR3GL -439 204
POLR3H -4401 5546
POLR3K -980 891
PPIA -1958 4555
PPIE -2923 6027
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5D 2123 3470
PPP3CA 1951 5980
PPP3CB 2717 4044
PPP3R1 2516 2945
PRCP 3614 611
PRDX6 2308 5478
PRKACA 4634 890
PRKACB -4510 1712
PRKCD 4519 6360
PRKCE 2768 -1185
PRKCQ -4282 4208
PRKCSH 2536 4698
PRKDC -2099 6476
PRTN3 -1895 5621
PSAP 3637 628
PSEN1 4223 4955
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PSTPIP1 3982 680
PTGES2 -2631 -901
PTK2 -81 -475
PTPN11 2499 5062
PTPN4 -3841 784
PTPN6 4000 6542
PTPRC 2525 -936
PTPRJ 4193 7170
PTPRN2 1186 6585
PYCARD 4187 -1820
PYGB -3 141
QPCT 4247 -1474
QSOX1 4636 5727
RAB10 4485 3067
RAB14 2619 -378
RAB18 2483 2764
RAB24 3244 -168
RAB27A 3787 222
RAB37 -885 409
RAB3A 2502 4348
RAB3D 4330 1148
RAB4B 3084 4688
RAB5B 3004 1957
RAB5C 3866 797
RAB6A 3957 3323
RAB7A 4110 -124
RAC1 4404 5541
RAC2 2815 4577
RAF1 3220 6573
RAP1A 3123 6569
RAP1B 3135 5968
RAP2B 1744 5292
RASGRP1 -4340 5888
RASGRP2 -3066 -413
RBSN -220 6354
RELA -360 4333
RELB 390 577
RHOA 3965 4033
RHOF -3727 6478
RHOG 4253 3664
RIPK3 4146 6795
RNASET2 3046 7090
RNF125 -4265 6176
RNF135 4465 -1615
RNF216 -3561 4491
ROCK1 3502 2732
RPS27A -4269 2589
RPS6KA1 4497 -1859
RPS6KA2 1476 2117
RPS6KA5 -4234 1991
S100A11 4403 6089
S100P 3960 3303
SARM1 -3909 4842
SCAMP1 -1690 2645
SDCBP 3944 3834
SERPINB1 4584 -1479
SERPINB6 2494 2823
SHC1 3684 3205
SIGIRR -2919 6807
SIKE1 -2413 1675
SKP1 -1442 2680
SLC11A1 4657 4001
SLC15A4 4272 -1577
SLC27A2 -1491 -1411
SLC2A3 4329 -1211
SLC44A2 1805 4323
SLCO4C1 3222 -99
SNAP23 3209 -471
SNAP29 3729 3148
SOCS1 1954 4130
SOS1 -1564 -1986
SPTAN1 -4215 -407
SRC -2136 -1476
SRP14 2428 5764
STAT6 3358 3854
STBD1 2421 -658
STK10 3259 -688
STK11IP 2803 2122
STOM 3315 -1586
SUGT1 -650 5005
SURF4 3260 3679
SVIP -231 1104
SYK 4235 431
TAB2 605 6401
TANK 3226 6239
TAX1BP1 2464 1037
TBC1D10C -3594 6912
TBK1 2175 599
TCIRG1 4397 1353
TEC 3744 170
TICAM1 2805 1060
TIFA -928 4848
TIRAP 3210 1661
TLR1 3767 -1113
TLR2 4229 4128
TLR3 -3155 2949
TLR5 4499 5701
TLR6 3198 -1201
TLR9 -1039 7204
TMBIM1 4011 -47
TMC6 -3143 6750
TMEM179B -174 5597
TMEM30A 2939 6660
TMEM63A -3975 2620
TNFAIP3 -891 6105
TNFRSF1B 4053 6870
TNIP2 2642 287
TOLLIP 3698 664
TOM1 4334 4280
TRAF2 -3445 5765
TRAF3 -3457 7209
TRAF6 957 -71
TRAPPC1 3635 5233
TREX1 196 -1436
TRIM21 1429 -1673
TRIM25 4384 446
TRIM56 -937 5740
TRPM2 4469 -1794
TSPAN14 4336 4963
TUBB -532 6248
TUBB4B 2796 7163
TXK -3927 4860
TXN 3643 -1735
TXNDC5 -1496 -1873
TXNIP -1224 6154
TYROBP 3657 -1997
UBA3 2970 4052
UBA52 -1041 -69
UBA7 -1692 -1591
UBB 509 5059
UBC 2477 3220
UBE2D1 3774 2741
UBE2D2 521 2134
UBE2D3 3445 3005
UBE2K 2378 3260
UBE2L6 -3166 1295
UBE2M 2900 2052
UBE2N -315 4834
UBE2V1 688 2792
UNC13D 4542 -1906
UNC93B1 4155 4749
VAMP8 592 868
VAPA 3892 4246
VAT1 4521 -1359
VAV1 3798 5834
VAV2 803 4134
VAV3 3247 -685
VCL 2594 3614
VCP 3034 1908
VRK3 2298 2903
VTN 365 -1927
WASF1 4564 -830
WASF2 4427 -134
WASL 522 4645
WIPF1 919 -784
WIPF2 3524 -1018
XRCC5 1586 1327
XRCC6 -2304 3282
YES1 -1029 5198
YPEL5 2436 3986
ZBP1 -2760 7177



Immune System

Immune System
metric value
setSize 1197
pMANOVA 2.34e-36
p.adjustMANOVA 8.73e-34
s.dist 0.225
s.RNA 0.223
s.meth 0.032
p.RNA 6.19e-36
p.meth 0.0736




Top 20 genes
Gene RNA meth
OSCAR 4628 7123
ATP6V0D1 4488 6936
CTSD 4618 6622
CLTC 4203 7259
PTPRJ 4193 7170
PLEKHO2 4455 6699
MMP25 4294 6854
KLHL2 4531 6411
COTL1 4275 6761
PRKCD 4519 6360
SOCS3 4419 6492
ITGB2 4462 6426
GM2A 4470 6363
STIM1 3891 7265
RIPK3 4146 6795
UBE2F 4050 6897
MYO9B 4114 6777
TNFRSF1B 4053 6870
MAPK1 4560 6099
CRK 4199 6598

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -376 567
AAAS -1807 1467
AAMP -2190 7121
ABCE1 -4598 6006
ABHD17A -1670 -550
ABHD17B -649 -676
ABI1 3644 3253
ABI2 -3635 -206
ABL1 1975 2469
ACAA1 4343 5790
ACLY 4076 2976
ACTB 4359 5447
ACTG1 3825 1603
ACTR10 2879 4868
ACTR1A 4039 1932
ACTR1B -2740 2629
ACTR2 3672 3844
ACTR3 3554 5952
ADAM10 4095 2760
ADAM17 4436 4155
ADAM8 2913 5097
ADAR 1862 3087
ADGRE5 3420 -1470
AGA -1464 2162
AGL -165 1016
AGPAT2 4525 -1388
AHCYL1 2934 2692
AIM2 -573 -1277
AIP -657 6684
AKT1 1891 1109
AKT2 781 5431
ALAD 4020 1057
ALDOA 4426 5367
ALDOC -2432 65
ALOX5 4460 5386
AMPD3 3980 3216
ANAPC1 -4482 2990
ANAPC10 -418 -1326
ANAPC11 1271 3188
ANAPC13 -1477 493
ANAPC2 -2051 2865
ANAPC4 -1105 -687
ANAPC5 -2994 5213
ANAPC7 175 1873
ANO6 1978 1102
AP1B1 4393 5783
AP1G1 2519 2214
AP1M1 3701 1777
AP1S3 -992 1942
AP2A1 4623 -316
AP2M1 3567 3723
AP2S1 3281 6039
APAF1 3421 -809
APBB1IP 4238 3821
APEH 1920 832
APP 2952 6623
APRT -2907 2643
AREL1 4008 5153
ARF1 4345 -1821
ARHGAP9 2946 6257
ARIH1 90 3751
ARIH2 -3208 3734
ARL2 -939 244
ARL8A 4001 -1058
ARMC8 1704 2641
ARPC1B 4422 1709
ARPC2 3659 2292
ARPC3 3630 3208
ARPC5 4209 2611
ARRB1 1885 -1278
ARRB2 4237 2913
ARSA 2606 523
ARSB 4014 -1528
ASAH1 4412 2174
ASB1 3322 6031
ASB13 361 1754
ASB2 -1279 6213
ASB6 686 -1069
ASB7 1157 6529
ASB8 2443 5453
ATAD3B -3760 4811
ATF1 1229 2989
ATG12 -1943 6823
ATG5 -502 -680
ATG7 2429 3847
ATOX1 2731 390
ATP11A 4198 132
ATP11B 2964 -241
ATP6V0A1 4546 -1571
ATP6V0A2 -2629 6653
ATP6V0B 3723 5503
ATP6V0C 4483 2933
ATP6V0D1 4488 6936
ATP6V0E1 3450 1836
ATP6V0E2 -4253 -1327
ATP6V1A 3956 -1497
ATP6V1B2 3836 -1555
ATP6V1C1 3831 6759
ATP6V1D 4067 1096
ATP6V1E1 3280 4776
ATP6V1F 1531 -699
ATP6V1G2 -4149 3740
ATP6V1H 3287 2559
ATP8A1 -4193 -913
ATP8B4 2620 -1100
B2M -2207 -9
B4GALT1 3113 7043
BAIAP2 -1012 2757
BATF 1760 6679
BCL10 2493 2575
BCL2 -3030 7022
BCL2L1 1477 5970
BCL6 4540 3669
BIN2 3741 5390
BIRC2 511 6626
BIRC3 -4591 4817
BIRC5 2356 1965
BLMH -428 -120
BRAF 1030 -1526
BRAP 2450 -135
BRI3 4445 -1178
BRK1 1195 3071
BRWD1 -2774 -349
BST2 -306 -1935
BTBD1 -24 120
BTBD6 -1546 3006
BTN2A1 -893 1617
BTN2A2 -3776 108
BTN3A1 -3378 1278
BTN3A2 -4524 3317
BTN3A3 -4211 6404
BTRC -1864 -923
C3AR1 4610 -1596
C6orf120 1825 3829
C8G -1547 -1366
CAB39 3640 7109
CALM1 263 4502
CALR 2667 5714
CAMK2D -4530 -529
CAMK2G -152 6718
CAND1 -2920 2163
CANX 1895 3479
CAP1 3919 2034
CAPN1 4333 1819
CAPZA1 3861 999
CAPZA2 3520 4667
CAPZB 3889 -308
CARD11 -4025 6544
CARD9 2714 -1763
CASP1 1192 7031
CASP10 216 -1807
CASP3 2079 5691
CASP4 2046 -96
CASP8 -1893 5448
CASP9 4537 3202
CAT 4134 -1206
CBL 3732 1012
CBLB -3384 343
CCND1 -2034 1006
CCNF -435 392
CCR1 3886 -1921
CCT2 -4539 194
CCT8 -92 2904
CD247 -3684 6036
CD274 -3754 -305
CD300A 3868 -2000
CD3D -3812 7274
CD3E -4247 7193
CD4 -2816 909
CD44 3690 4898
CD46 1453 5540
CD47 -4015 6603
CD53 4111 6484
CD55 4493 1455
CD58 3673 -611
CD59 1662 -1684
CD63 4635 5434
CD74 -3538 -648
CD79B -3689 -1167
CD81 -1239 3296
CD96 -4584 6878
CDC16 -1889 3340
CDC20 1721 2639
CDC23 -3699 1597
CDC34 3770 -408
CDC42 3449 856
CDK13 436 5779
CDKN1A 2283 2427
CEACAM1 2004 5459
CEBPD 4308 -907
CENPE 2579 -74
CEP290 -3173 7002
CFL1 3970 1646
CHUK 3354 1111
CISH -1047 4928
CKAP4 4383 -987
CLEC2B -2655 2668
CLTA 3106 -546
CLTC 4203 7259
CMTM6 3768 1926
CNN2 2979 -418
CNPY3 2764 1242
COMMD3 -955 -1962
COMMD9 2968 2239
COPB1 3055 2637
COTL1 4275 6761
CPNE1 -985 5132
CPNE3 1782 -1443
CPPED1 3977 -641
CRCP 2844 4708
CREB1 -1458 1422
CREBBP 2340 892
CREG1 3715 -1060
CRK 4199 6598
CRKL 1455 5167
CSF1 -551 356
CSK 3371 4890
CSNK2B 1983 4743
CSTB 3694 2893
CTF1 2571 543
CTLA4 -3441 7091
CTNNB1 3473 5070
CTSA 4474 2720
CTSB 4614 -965
CTSC 3824 1311
CTSD 4618 6622
CTSL 4277 3028
CTSO -3106 5111
CTSS 2705 -1546
CTSV -1816 5170
CTSZ 4030 -1980
CUL1 -4005 -1192
CUL2 139 2207
CUL3 2435 -873
CUL5 -968 344
CUL7 1343 6188
CXCL2 440 -1990
CYB5R3 4411 3239
CYBA 4037 2019
CYFIP1 4176 256
CYFIP2 -1121 6159
CYLD -4559 5706
CYSTM1 4340 -1742
DAPP1 326 6838
DBNL 3658 -406
DCTN2 4315 -727
DCTN3 2651 2751
DCTN4 4328 4417
DCTN5 -160 6060
DCTN6 2977 6882
DDX41 568 4426
DDX58 -3438 185
DEGS1 1764 3203
DERA 3865 3602
DET1 -2644 122
DGAT1 1176 -576
DHX36 -922 6440
DHX58 -1608 -30
DHX9 -1320 5547
DIAPH1 2862 2371
DLG1 -2579 358
DLG2 -429 -40
DLG4 3550 2607
DNAJC13 3911 408
DNAJC3 3890 6472
DNAJC5 4183 -1398
DNM1 2517 1607
DNM2 3828 3063
DPP7 -2342 6586
DSN1 -1681 -997
DTX4 3109 5144
DUSP1 2453 2023
DUSP10 174 4700
DUSP16 -3228 28
DUSP2 -2620 7009
DUSP3 2975 2260
DUSP4 -384 2494
DUSP5 -263 6280
DUSP6 -702 -1943
DUSP7 -732 722
DYNC1H1 416 4434
DYNC1I2 3229 693
DYNC1LI1 3337 3242
DYNC1LI2 2324 -185
DYNLL1 1152 5151
DYNLL2 -1545 -924
DYNLT1 2448 5601
DZIP3 -4529 -958
ECSIT 954 1450
EDARADD -3735 6841
EEA1 503 5335
EEF1A1 -4143 2941
EEF2 -2045 4196
EGR1 -1170 1893
EIF2AK2 1466 683
EIF4A1 2418 881
EIF4A2 -4411 3601
EIF4A3 1061 4598
EIF4E 1167 6721
EIF4E2 2223 5876
EIF4E3 3349 -661
EIF4G1 4177 5766
EIF4G2 2274 6373
EIF4G3 4441 1034
ELMO1 1982 939
ELMO2 4026 6110
ENPP4 -162 3170
EP300 3478 4901
ERAP1 -2947 1806
ERAP2 779 -756
ERBB2 -2008 4160
ERP44 2444 920
EVL -4381 7075
FABP5 2835 2233
FADD 3156 -329
FAF2 2633 2842
FBXL12 -490 4059
FBXL14 -2216 6756
FBXL15 500 970
FBXL16 -4552 6378
FBXL18 3459 853
FBXL19 4322 -220
FBXL20 2347 1213
FBXL22 -2350 5652
FBXL3 87 2065
FBXL4 1692 1511
FBXL5 4033 6720
FBXL8 -734 5373
FBXO11 2992 7064
FBXO15 966 2131
FBXO21 -3050 6290
FBXO22 -876 -930
FBXO30 1495 1907
FBXO31 -4394 4756
FBXO32 -4013 6488
FBXO4 -4249 106
FBXO6 1775 92
FBXO7 1597 2923
FBXO9 4538 3195
FBXW11 2170 -1508
FBXW2 4166 2654
FBXW4 -3367 136
FBXW5 1572 -1872
FBXW7 -1004 6667
FBXW8 -2115 4559
FGF9 -3638 997
FGR 4616 -1075
FKBP1A 3631 1814
FLNB 2441 675
FLT3LG -4600 6677
FNTA -1333 694
FNTB 647 -1385
FOS 692 5647
FOXO1 -4458 3034
FOXO3 3816 5023
FRS2 -959 -882
FRS3 2713 6525
FTH1 2313 3117
FTL 4047 -1426
FUCA1 2386 1656
FUCA2 2692 -1236
FYN -1686 2793
FZR1 564 2326
GAA 3199 2768
GAB2 4007 2390
GALNS 3231 3670
GAN -11 3655
GATA3 -4581 6274
GBP3 -4088 89
GCA 4476 5561
GDI2 2972 3343
GGH 3052 3861
GHDC 552 -571
GLB1 4153 1828
GLIPR1 1534 5593
GLMN -4035 -22
GM2A 4470 6363
GMFG 3664 6369
GNS 4646 4429
GOLGA7 648 3104
GPI 3145 5674
GRAP2 -265 3631
GRB2 4420 6241
GRIN2D 3552 3069
GRN 4424 4938
GSDMD -146 -91
GSTO1 3901 3633
GSTP1 433 -1352
GUSB 4577 2338
GYG1 4447 -231
GZMM -2941 7252
HACE1 -1288 -395
HBEGF 646 -1007
HCST -178 1324
HEBP2 2475 552
HECTD1 277 5901
HECTD3 3312 463
HERC1 -656 1913
HERC3 1465 3912
HERC4 1376 232
HERC5 -2560 -1038
HEXB 3333 2906
HGSNAT 472 3342
HIF1A 3440 2448
HLA-A -2315 -1094
HLA-B 157 -730
HLA-C 725 4449
HLA-DMA -3241 -1928
HLA-E 766 5636
HLA-F -2858 2974
HLA-H -726 4989
HMGB1 -1409 3222
HMOX2 -3777 6413
HNRNPA2B1 979 2721
HNRNPF 839 5857
HRAS -2340 -823
HSP90AA1 -729 6210
HSP90AB1 -4016 -1226
HSP90B1 -436 2127
HSPA1A 3351 -920
HSPA1B 2487 655
HSPA9 -4169 6551
HVCN1 -239 -385
ICAM1 170 2036
ICAM2 -4307 4819
ICAM3 2236 6840
ICAM5 4526 4186
ICMT 465 2626
ICOSLG -3243 4497
IDH1 4649 3454
IFI30 4212 -1604
IFI35 1098 1292
IFI6 1316 5537
IFIH1 -2787 2681
IFIT1 -1523 312
IFIT2 -2954 1477
IFIT3 -1411 6161
IFIT5 -2519 3745
IFITM1 -894 6985
IFNAR1 3467 1219
IFNAR2 3120 1115
IFNGR1 4425 4124
IFNGR2 4592 4231
IGF2R 4158 -1659
IKBKB -510 -912
IKBKE 2509 6705
IL10RA -106 5518
IL10RB 4566 -1076
IL12A -3557 -1317
IL12RB1 -2265 6632
IL12RB2 -3177 -1861
IL15 -1033 3611
IL15RA 67 -1087
IL16 -1859 5458
IL17C 1334 -1130
IL17RA 4468 130
IL17RC -1500 1939
IL18BP -1294 -1640
IL18R1 3014 6744
IL19 3167 7266
IL1RAP 3464 -1122
IL21R -3300 2722
IL23A -4577 7078
IL27RA 1558 6659
IL2RA -2715 6868
IL2RB -4098 7237
IL32 -4046 7268
IL4R 3584 1274
IL6R 2774 5066
IL6ST -361 1708
ILF2 -1315 2770
IMPDH1 4587 2600
IMPDH2 -4613 250
INPP5D 3164 55
INPPL1 3940 588
IP6K2 -1388 799
IQGAP1 4024 587
IQGAP2 3573 3888
IRAK2 -1227 4686
IRAK3 4491 666
IRF1 -2390 5832
IRF2 3133 2365
IRF3 -2846 4241
IRF4 -3348 5941
IRF5 2869 -1651
IRF7 856 3556
IRF9 -803 4775
IRS1 -2666 4308
IRS2 3955 6152
ISG15 -2022 6541
ISG20 -2977 7060
IST1 3188 1014
ITCH 2362 4854
ITGA4 -3400 -394
ITGAL 761 7038
ITGAV 2675 -370
ITGB2 4462 6426
ITGB7 -3868 -1691
ITK -4418 -1701
ITPR1 -1851 1789
ITPR2 2474 -44
ITPR3 -2973 2189
JAK1 -2308 -283
JAK2 1159 6489
JUN -400 1283
JUNB 2048 5018
KBTBD6 -1389 80
KBTBD7 2876 -381
KBTBD8 -1089 834
KCMF1 3303 3310
KCNAB2 2568 -600
KCTD6 2053 -621
KCTD7 -4114 1682
KEAP1 3048 1379
KIF11 1038 1895
KIF15 127 6309
KIF18A 75 3290
KIF20A 1510 1403
KIF22 -4500 6183
KIF23 1200 805
KIF2A -2268 4006
KIF2C 1020 -12
KIF3A -4235 6174
KIF3B 1598 2018
KIF3C 3608 -1430
KIF5B 3295 4670
KIFAP3 -995 -68
KLC1 2928 4386
KLC2 -2845 1505
KLC4 -2245 4367
KLHL11 -1676 5349
KLHL2 4531 6411
KLHL20 -2158 1429
KLHL21 1141 5917
KLHL22 -4003 1129
KLHL25 -4246 4489
KLHL5 -2834 3248
KPNA1 -443 4423
KPNA2 66 4421
KPNA3 -12 4400
KPNA4 2166 5000
KPNA5 -4039 1847
KPNB1 1964 1140
KRAS 2245 3139
KSR1 3863 7147
LAIR1 4508 3425
LAMP1 3979 2553
LAMTOR1 3714 -1589
LAMTOR2 3191 -1342
LAMTOR3 2265 957
LAT2 4233 -1716
LCK -4408 7246
LCP1 4185 4312
LCP2 1073 -428
LGALS9 3845 -1462
LGMN -2658 2706
LIMK1 3007 -1750
LMNB1 4349 1051
LMO7 -4378 7262
LNPEP -522 2406
LONRF1 2965 6153
LPCAT1 2522 1418
LRMP 1482 -296
LRR1 -1924 3790
LRRC41 4069 2878
LRRFIP1 3688 5297
LRSAM1 3620 5944
LTA -4469 7256
LTA4H 4283 798
LTB -4525 5586
LTN1 -1200 7198
LYPLA1 3207 2159
MALT1 -4594 2545
MAN2B1 2177 6389
MANBA 2899 6846
MAP2K1 4239 1533
MAP2K2 2556 6410
MAP2K3 4152 2411
MAP2K4 2698 4764
MAP2K6 4437 4792
MAP2K7 -54 1764
MAP3K1 2034 2247
MAP3K11 4002 1270
MAP3K14 -4023 4221
MAP3K3 4145 3121
MAP3K7 1566 -147
MAP3K8 4603 3266
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
MAPK7 3610 -244
MAPK8 -3916 4554
MAPK9 -1532 157
MAPKAP1 1834 5908
MAPKAPK2 3498 3265
MAPKAPK3 4597 2896
MARK3 4168 3805
MAVS 2866 4281
MEF2A 3826 3013
MEX3C -3178 6169
MGRN1 3457 -1405
MICA -701 3105
MICB 2616 3131
MIF -2780 3355
MKRN1 2433 2197
MLEC 526 2183
MLST8 -394 2258
MMP25 4294 6854
MNDA 3547 -1996
MPO -1063 -1969
MRC2 -1993 -577
MT2A 595 1186
MTAP -2689 2271
MTOR -141 3900
MUC1 1680 6715
MUC12 -806 4641
MUC5B 2049 -1745
MVP 3194 6955
MX1 -1283 -1016
MX2 4243 1798
MYD88 4594 1945
MYH9 3463 6146
MYLIP -1584 2479
MYO9B 4114 6777
NAPRT 3692 -1871
NBEAL2 3989 1726
NCF4 4148 -1941
NCK1 -3877 1018
NCKAP1L 4619 -320
NCKIPSD -1667 667
NCSTN 4654 1224
NDC1 -4582 6482
NDUFC2 2185 2881
NEDD4 3884 -1106
NEDD4L 2846 -1080
NEU1 4492 1899
NF1 2485 -328
NF2 1372 1410
NFATC1 -2143 6947
NFATC2 -3732 7159
NFATC3 -2782 1668
NFKB2 -2276 5251
NFKBIA 1525 6814
NFKBIB 2303 5574
NFKBIE -2388 4747
NHLRC3 1939 4506
NIT2 -4036 -141
NKIRAS1 -1505 348
NKIRAS2 4544 -1132
NLRC5 -1747 1905
NLRP1 -2338 3033
NLRP3 3568 -847
NLRX1 4202 768
NME2 9 -880
NOD1 -1776 -321
NOD2 3807 6610
NOS3 -3550 4048
NPC2 1910 2198
NUP107 -3437 6301
NUP133 -2181 935
NUP153 -709 4344
NUP155 -3052 3043
NUP160 -3890 1293
NUP188 -3651 2922
NUP205 -3468 1670
NUP210 -1977 690
NUP214 3636 4369
NUP35 -4479 -557
NUP37 126 3398
NUP43 -3608 6346
NUP50 1354 6706
NUP54 -3105 831
NUP62 -1130 4609
NUP85 -1192 4518
NUP88 -4449 7084
NUP93 -2021 2006
NUP98 1358 -747
OAS1 1163 -1507
OAS2 -1852 6618
OAS3 -1975 616
OASL 1791 5929
ORAI1 -1998 2153
ORAI2 2958 -132
ORMDL3 -2693 3085
OSCAR 4628 7123
OSM 2650 1355
OSTF1 3412 6470
P2RX1 4648 -1949
P4HB 4143 5718
PA2G4 -1614 5243
PAFAH1B2 2581 2435
PAG1 2231 6279
PAK1 3814 2452
PAK2 3574 283
PANX1 3249 3960
PAQR3 -786 2041
PCBP2 2 3201
PDAP1 3353 2952
PDCD4 -4504 4220
PDE12 -463 6083
PDE3B -4123 3507
PDE6D 1876 4822
PDIA3 1941 4846
PDPK1 3218 346
PDXK 3330 1492
PEA15 -1894 7145
PEBP1 -4410 4325
PELI1 1886 1867
PELI2 2557 7035
PELI3 3582 -1123
PFKL -1392 -1732
PGAM1 4549 1307
PGM1 2618 776
PGM2 4264 5134
PHB -2116 4542
PIAS1 2064 2845
PIK3AP1 4435 1373
PIK3CA 946 1470
PIK3CD 2671 6109
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R3 995 3645
PIK3R4 -1326 2170
PILRB -2559 2683
PIM1 2364 1390
PIN1 -43 4014
PITPNA 3938 3616
PJA2 3294 2112
PKM 4341 3231
PLA2G6 -3342 826
PLAC8 4527 1235
PLAU 1259 -1529
PLAUR 4124 -861
PLCG1 -4367 958
PLCG2 3848 2803
PLD1 4582 -902
PLD3 2082 354
PLEKHO2 4455 6699
PML -714 4575
PNP 2649 3516
POLR1C -4305 5329
POLR1D 1066 6782
POLR2E 2119 3712
POLR2F 1375 509
POLR2H -2765 6299
POLR2K -1277 3853
POLR3A -15 5226
POLR3C -1330 3978
POLR3D -4218 1967
POLR3E -4103 1113
POLR3F -2735 -1023
POLR3G -1938 6661
POLR3GL -439 204
POLR3H -4401 5546
POLR3K -980 891
POM121 -1045 4681
POM121C -663 2061
POU2F1 2656 3909
PPIA -1958 4555
PPIE -2923 6027
PPM1B 3092 -144
PPP1CB 2691 -340
PPP1CC 1107 5379
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5A 3674 -230
PPP2R5B 3304 -286
PPP2R5C -1671 7074
PPP2R5D 2123 3470
PPP2R5E -4 1402
PPP3CA 1951 5980
PPP3CB 2717 4044
PPP3R1 2516 2945
PPP5C -1013 5721
PRCP 3614 611
PRDX6 2308 5478
PRKACA 4634 890
PRKACB -4510 1712
PRKCB 3491 4964
PRKCD 4519 6360
PRKCE 2768 -1185
PRKCQ -4282 4208
PRKCSH 2536 4698
PRKDC -2099 6476
PRR5 -2935 -347
PRTN3 -1895 5621
PSAP 3637 628
PSEN1 4223 4955
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PSTPIP1 3982 680
PTEN 3783 4815
PTGES2 -2631 -901
PTK2 -81 -475
PTK2B 4451 4529
PTPN1 4210 699
PTPN11 2499 5062
PTPN12 3373 -982
PTPN13 -2147 6850
PTPN18 4484 3436
PTPN2 3642 181
PTPN22 2377 5982
PTPN23 1520 5427
PTPN4 -3841 784
PTPN6 4000 6542
PTPN7 -570 2323
PTPN9 4524 6096
PTPRA 2152 6358
PTPRC 2525 -936
PTPRJ 4193 7170
PTPRN2 1186 6585
PYCARD 4187 -1820
PYGB -3 141
QPCT 4247 -1474
QSOX1 4636 5727
RAB10 4485 3067
RAB14 2619 -378
RAB18 2483 2764
RAB24 3244 -168
RAB27A 3787 222
RAB37 -885 409
RAB3A 2502 4348
RAB3D 4330 1148
RAB4B 3084 4688
RAB5B 3004 1957
RAB5C 3866 797
RAB6A 3957 3323
RAB7A 4110 -124
RAC1 4404 5541
RAC2 2815 4577
RACGAP1 2182 4089
RAE1 1241 2634
RAF1 3220 6573
RALA -2065 2302
RALGDS -3164 6406
RANBP2 -757 5165
RANBP9 2528 884
RAP1A 3123 6569
RAP1B 3135 5968
RAP2B 1744 5292
RAPGEF1 1580 6445
RASA1 1788 3434
RASA2 -74 2632
RASA3 -4225 187
RASAL1 -1471 5685
RASAL3 -3093 2544
RASGRP1 -4340 5888
RASGRP2 -3066 -413
RASGRP3 -3423 760
RBBP6 -1715 2861
RBCK1 2276 -510
RBSN -220 6354
RBX1 2032 5883
RCE1 -1527 3297
RCHY1 1601 6486
REL 2346 1779
RELA -360 4333
RELB 390 577
RGL1 4405 3381
RGL2 2856 4879
RHOA 3965 4033
RHOF -3727 6478
RHOG 4253 3664
RICTOR -2640 2833
RILP 3512 4299
RIPK3 4146 6795
RNASEL 4301 3400
RNASET2 3046 7090
RNF111 1846 6049
RNF114 1182 6
RNF115 -277 5805
RNF123 3286 5285
RNF125 -4265 6176
RNF126 -3185 5634
RNF135 4465 -1615
RNF138 -2164 7053
RNF14 1755 -1372
RNF144B 4300 -81
RNF19A -1030 6514
RNF19B 2153 2765
RNF213 -1390 7097
RNF216 -3561 4491
RNF220 -1268 215
RNF25 -833 5177
RNF34 -780 1414
RNF4 -618 4133
RNF41 4019 4402
RNF6 342 366
RNF7 3181 5841
ROCK1 3502 2732
RORA -4196 6933
RPLP0 -3580 4851
RPS27A -4269 2589
RPS6KA1 4497 -1859
RPS6KA2 1476 2117
RPS6KA5 -4234 1991
S100A11 4403 6089
S100P 3960 3303
S1PR1 -1875 6791
SAMHD1 3465 6191
SAR1B 2728 3060
SARM1 -3909 4842
SCAMP1 -1690 2645
SDCBP 3944 3834
SEC13 2199 6211
SEC23A 2702 1833
SEC24A 3575 4762
SEC24B 2183 -13
SEC24C 2332 -336
SEC24D 4409 1527
SEC31A 1591 2523
SEC61A1 2782 421
SEC61A2 -2339 301
SEC61B 1866 6424
SEC61G 24 1928
SEH1L -4328 3577
SERPINB1 4584 -1479
SERPINB6 2494 2823
SH2B1 -2743 1436
SHC1 3684 3205
SHOC2 2762 34
SIAH1 45 494
SIAH2 2586 6697
SIGIRR -2919 6807
SIKE1 -2413 1675
SIPA1 2787 -1270
SKP1 -1442 2680
SKP2 -1179 1707
SLAMF6 -3403 6836
SLC11A1 4657 4001
SLC15A4 4272 -1577
SLC27A2 -1491 -1411
SLC2A3 4329 -1211
SLC44A2 1805 4323
SLCO4C1 3222 -99
SMAD3 -3734 -363
SMARCA4 3223 6792
SMURF1 1871 6934
SMURF2 -2759 3523
SNAP23 3209 -471
SNAP29 3729 3148
SNRPA1 -3020 1539
SOCS1 1954 4130
SOCS2 -1172 6479
SOCS3 4419 6492
SOCS5 -381 466
SOD1 -2469 1838
SOD2 2190 6134
SOS1 -1564 -1986
SOS2 3721 3699
SP100 3530 2285
SPRED1 1438 6065
SPRED2 4200 5462
SPRED3 382 5938
SPSB1 1120 582
SPTAN1 -4215 -407
SPTBN1 -3763 3657
SPTBN5 914 2256
SQSTM1 -377 658
SRC -2136 -1476
SRP14 2428 5764
STAT1 -4254 4970
STAT2 -1754 5933
STAT3 3772 4995
STAT4 -4008 4203
STAT5A 2951 -1545
STAT5B 2832 1495
STAT6 3358 3854
STBD1 2421 -658
STIM1 3891 7265
STK10 3259 -688
STK11IP 2803 2122
STOM 3315 -1586
STUB1 -602 2320
STX1A 1013 4174
STX3 3765 2712
STX4 2105 1609
STXBP2 4595 -155
SUGT1 -650 5005
SUMO1 2118 3368
SURF4 3260 3679
SVIP -231 1104
SYK 4235 431
SYNGAP1 -3633 1191
TAB2 605 6401
TALDO1 4236 4422
TANK 3226 6239
TAP1 -3154 3742
TAP2 -2149 3057
TAPBP 2263 2910
TAX1BP1 2464 1037
TBC1D10C -3594 6912
TBK1 2175 599
TCIRG1 4397 1353
TCP1 -1018 -448
TEC 3744 170
TGFA 4325 4632
TGFB1 2241 3769
THEM4 -4605 809
THOP1 -2752 3555
TICAM1 2805 1060
TIFA -928 4848
TIRAP 3210 1661
TLN1 4172 -983
TLR1 3767 -1113
TLR2 4229 4128
TLR3 -3155 2949
TLR5 4499 5701
TLR6 3198 -1201
TLR9 -1039 7204
TMBIM1 4011 -47
TMC6 -3143 6750
TMEM179B -174 5597
TMEM30A 2939 6660
TMEM63A -3975 2620
TNF -1302 -526
TNFAIP3 -891 6105
TNFRSF12A 3115 681
TNFRSF1A 4400 -1548
TNFRSF1B 4053 6870
TNFRSF25 -4616 6989
TNFSF13 4042 -1364
TNFSF13B 3490 -384
TNFSF14 2181 7178
TNFSF9 811 447
TNIP2 2642 287
TOLLIP 3698 664
TOM1 4334 4280
TP53 -4050 2709
TPP2 -4037 2610
TPR -1675 4616
TRAF2 -3445 5765
TRAF3 -3457 7209
TRAF6 957 -71
TRAF7 4385 4601
TRAIP -3171 2585
TRAPPC1 3635 5233
TREML2 3151 -1970
TREX1 196 -1436
TRIB3 207 3767
TRIM11 -29 5179
TRIM14 2011 1982
TRIM2 -3942 646
TRIM21 1429 -1673
TRIM22 -952 2278
TRIM25 4384 446
TRIM26 1026 3540
TRIM35 -2444 1556
TRIM36 1025 -1287
TRIM37 -2425 3725
TRIM38 2198 4883
TRIM39 -1827 6698
TRIM4 -1425 7144
TRIM41 2688 7011
TRIM45 -1684 -1041
TRIM46 -4061 3136
TRIM5 1579 395
TRIM56 -937 5740
TRIM62 -1143 3890
TRIM68 -3239 -539
TRIM8 4192 6375
TRIM9 1323 3459
TRIP12 3869 6255
TRPC1 -3897 -631
TRPM2 4469 -1794
TSPAN14 4336 4963
TUBB -532 6248
TUBB4B 2796 7163
TXK -3927 4860
TXLNA -114 7007
TXN 3643 -1735
TXNDC5 -1496 -1873
TXNIP -1224 6154
TYK2 3852 4072
TYROBP 3657 -1997
UBA3 2970 4052
UBA5 -3089 911
UBA52 -1041 -69
UBA6 1636 -917
UBA7 -1692 -1591
UBAC1 3542 -157
UBB 509 5059
UBC 2477 3220
UBE2B 2042 5147
UBE2C 1221 4535
UBE2D1 3774 2741
UBE2D2 521 2134
UBE2D3 3445 3005
UBE2D4 -2880 915
UBE2E1 68 2408
UBE2E2 -1696 2070
UBE2E3 288 -777
UBE2F 4050 6897
UBE2G1 1799 214
UBE2G2 -4319 6799
UBE2H 3432 1146
UBE2J1 3682 1013
UBE2J2 2786 6013
UBE2K 2378 3260
UBE2L3 3091 119
UBE2L6 -3166 1295
UBE2M 2900 2052
UBE2N -315 4834
UBE2O -763 6887
UBE2Q1 2037 2054
UBE2Q2 -4044 -223
UBE2R2 4178 -1209
UBE2S 1470 -706
UBE2V1 688 2792
UBE2V2 389 3547
UBE2W 2359 5413
UBE2Z -2330 6571
UBE3A 31 2812
UBE3B 1810 709
UBE3C 2322 6991
UBE3D -3310 -1597
UBOX5 2125 5848
UBR1 146 460
UBR2 2471 2591
UFL1 -1062 3864
UNC13D 4542 -1906
UNC93B1 4155 4749
UNKL -501 -1603
USP18 -1086 -1013
VAMP2 -3963 -1239
VAMP3 3838 619
VAMP8 592 868
VAPA 3892 4246
VASP 4003 1142
VAT1 4521 -1359
VAV1 3798 5834
VAV2 803 4134
VAV3 3247 -685
VCL 2594 3614
VCP 3034 1908
VEGFA 2025 87
VHL 1347 5209
VIM 4522 3780
VRK3 2298 2903
VTN 365 -1927
WASF1 4564 -830
WASF2 4427 -134
WASL 522 4645
WDR83 2132 5497
WIPF1 919 -784
WIPF2 3524 -1018
WSB1 4407 4175
WWP1 -4551 479
XAF1 -2044 -1464
XRCC5 1586 1327
XRCC6 -2304 3282
YES1 -1029 5198
YPEL5 2436 3986
YWHAB 2512 2152
YWHAZ 2353 4294
ZAP70 -3971 7251
ZBP1 -2760 7177
ZBTB16 3255 -42
ZEB1 -3353 5937
ZNRF1 1139 -819
ZNRF2 105 3277



rRNA processing

rRNA processing
metric value
setSize 159
pMANOVA 3.55e-31
p.adjustMANOVA 9.92e-29
s.dist 0.552
s.RNA -0.538
s.meth 0.123
p.RNA 1.26e-31
p.meth 0.00786




Top 20 genes
Gene RNA meth
TSR1 -4435 6839
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
NOP2 -3984 6403
RPS12 -3875 6331
RPL32 -4069 6000
EXOSC2 -4475 5344
RPS5 -3931 6072
SNU13 -3338 7054
WDR43 -4245 5510
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
UTP15 -4147 5063

Click HERE to show all gene set members

All member genes
RNA meth
BMS1 -4345 -1755
BYSL -2249 6808
C1D 763 2322
CSNK1D 2488 3046
CSNK1E -2944 3000
DCAF13 -2402 862
DDX21 510 3312
DDX47 -4298 -50
DDX49 1396 5582
DDX52 927 -204
DHX37 -2117 4195
DIS3 -1331 -754
EBNA1BP2 -2609 6235
ELAC2 -1929 275
ERI1 2515 -139
EXOSC1 114 316
EXOSC10 -3062 802
EXOSC2 -4475 5344
EXOSC3 -127 3245
EXOSC4 3882 64
EXOSC5 -3672 790
EXOSC6 -2037 1534
EXOSC7 -3466 -158
EXOSC8 -4275 1364
FAU -1142 6877
FBL -4453 -43
FCF1 1012 6763
FTSJ3 37 4236
GAR1 -2663 879
GNL3 -4514 1201
HEATR1 -3399 5201
IMP3 -3090 5542
IMP4 -3470 3786
ISG20L2 1554 6438
KRR1 -3409 -1952
LTV1 -2899 2915
MPHOSPH10 -3582 5401
MPHOSPH6 -247 5535
MRM1 -4209 -159
MTERF4 -4550 3503
NCL -3844 5054
NHP2 -2502 4827
NIP7 -2710 4219
NOB1 -3712 2003
NOC4L 535 -799
NOL11 -4544 2571
NOL12 970 -1551
NOL6 -3657 4557
NOL9 -3988 -1446
NOP10 4046 2081
NOP14 -4344 2209
NOP2 -3984 6403
NOP56 -4355 996
NOP58 -4534 1333
NSUN4 842 3316
PDCD11 -2672 3455
PELP1 -3840 2742
PES1 -1937 3288
PNO1 -2601 6496
PWP2 -202 5076
RBM28 -2634 3412
RCL1 -2883 6343
RIOK1 -1965 6498
RIOK2 -2842 1638
RIOK3 2889 3472
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPP14 118 2236
RPP21 -2049 2599
RPP25 -3481 5745
RPP30 -3480 668
RPP38 -3570 4780
RPP40 -4564 570
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
RRP1 -978 5200
RRP7A -1380 1582
RRP9 -3749 653
SENP3 -372 5394
SNU13 -3338 7054
TBL3 -235 5418
TEX10 -3806 1204
TFB1M -2921 1831
THUMPD1 -4426 -871
TRMT112 -966 1929
TSR1 -4435 6839
TSR3 1137 6370
UBA52 -1041 -69
UTP15 -4147 5063
UTP18 1330 3357
UTP20 -3435 5085
UTP3 -1599 3926
UTP6 -3440 3932
WDR12 475 6794
WDR18 -1194 -1078
WDR3 -3009 -1387
WDR36 -2277 6601
WDR43 -4245 5510
WDR75 -4506 4614
XRN2 4157 -29



rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol
metric value
setSize 154
pMANOVA 2.7e-30
p.adjustMANOVA 6.05e-28
s.dist 0.554
s.RNA -0.537
s.meth 0.133
p.RNA 1.41e-30
p.meth 0.00459




Top 20 genes
Gene RNA meth
TSR1 -4435 6839
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
NOP2 -3984 6403
RPS12 -3875 6331
RPL32 -4069 6000
EXOSC2 -4475 5344
RPS5 -3931 6072
SNU13 -3338 7054
WDR43 -4245 5510
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
UTP15 -4147 5063

Click HERE to show all gene set members

All member genes
RNA meth
BMS1 -4345 -1755
BYSL -2249 6808
C1D 763 2322
CSNK1D 2488 3046
CSNK1E -2944 3000
DCAF13 -2402 862
DDX21 510 3312
DDX47 -4298 -50
DDX49 1396 5582
DDX52 927 -204
DHX37 -2117 4195
DIS3 -1331 -754
EBNA1BP2 -2609 6235
ERI1 2515 -139
EXOSC1 114 316
EXOSC10 -3062 802
EXOSC2 -4475 5344
EXOSC3 -127 3245
EXOSC4 3882 64
EXOSC5 -3672 790
EXOSC6 -2037 1534
EXOSC7 -3466 -158
EXOSC8 -4275 1364
FAU -1142 6877
FBL -4453 -43
FCF1 1012 6763
FTSJ3 37 4236
GAR1 -2663 879
GNL3 -4514 1201
HEATR1 -3399 5201
IMP3 -3090 5542
IMP4 -3470 3786
ISG20L2 1554 6438
KRR1 -3409 -1952
LTV1 -2899 2915
MPHOSPH10 -3582 5401
MPHOSPH6 -247 5535
NCL -3844 5054
NHP2 -2502 4827
NIP7 -2710 4219
NOB1 -3712 2003
NOC4L 535 -799
NOL11 -4544 2571
NOL12 970 -1551
NOL6 -3657 4557
NOL9 -3988 -1446
NOP10 4046 2081
NOP14 -4344 2209
NOP2 -3984 6403
NOP56 -4355 996
NOP58 -4534 1333
PDCD11 -2672 3455
PELP1 -3840 2742
PES1 -1937 3288
PNO1 -2601 6496
PWP2 -202 5076
RBM28 -2634 3412
RCL1 -2883 6343
RIOK1 -1965 6498
RIOK2 -2842 1638
RIOK3 2889 3472
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPP14 118 2236
RPP21 -2049 2599
RPP25 -3481 5745
RPP30 -3480 668
RPP38 -3570 4780
RPP40 -4564 570
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
RRP1 -978 5200
RRP7A -1380 1582
RRP9 -3749 653
SENP3 -372 5394
SNU13 -3338 7054
TBL3 -235 5418
TEX10 -3806 1204
THUMPD1 -4426 -871
TRMT112 -966 1929
TSR1 -4435 6839
TSR3 1137 6370
UBA52 -1041 -69
UTP15 -4147 5063
UTP18 1330 3357
UTP20 -3435 5085
UTP3 -1599 3926
UTP6 -3440 3932
WDR12 475 6794
WDR18 -1194 -1078
WDR3 -3009 -1387
WDR36 -2277 6601
WDR43 -4245 5510
WDR75 -4506 4614
XRN2 4157 -29



Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol
metric value
setSize 147
pMANOVA 3.99e-30
p.adjustMANOVA 7.44e-28
s.dist 0.565
s.RNA -0.548
s.meth 0.135
p.RNA 1.97e-30
p.meth 0.00505




Top 20 genes
Gene RNA meth
TSR1 -4435 6839
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
EXOSC2 -4475 5344
RPS5 -3931 6072
SNU13 -3338 7054
WDR43 -4245 5510
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
UTP15 -4147 5063
WDR75 -4506 4614

Click HERE to show all gene set members

All member genes
RNA meth
BMS1 -4345 -1755
BYSL -2249 6808
C1D 763 2322
CSNK1D 2488 3046
CSNK1E -2944 3000
DCAF13 -2402 862
DDX21 510 3312
DDX47 -4298 -50
DDX49 1396 5582
DDX52 927 -204
DHX37 -2117 4195
DIS3 -1331 -754
EBNA1BP2 -2609 6235
ERI1 2515 -139
EXOSC1 114 316
EXOSC10 -3062 802
EXOSC2 -4475 5344
EXOSC3 -127 3245
EXOSC4 3882 64
EXOSC5 -3672 790
EXOSC6 -2037 1534
EXOSC7 -3466 -158
EXOSC8 -4275 1364
FAU -1142 6877
FBL -4453 -43
FCF1 1012 6763
FTSJ3 37 4236
GNL3 -4514 1201
HEATR1 -3399 5201
IMP3 -3090 5542
IMP4 -3470 3786
ISG20L2 1554 6438
KRR1 -3409 -1952
LTV1 -2899 2915
MPHOSPH10 -3582 5401
MPHOSPH6 -247 5535
NCL -3844 5054
NIP7 -2710 4219
NOB1 -3712 2003
NOC4L 535 -799
NOL11 -4544 2571
NOL12 970 -1551
NOL6 -3657 4557
NOL9 -3988 -1446
NOP14 -4344 2209
NOP56 -4355 996
NOP58 -4534 1333
PDCD11 -2672 3455
PELP1 -3840 2742
PES1 -1937 3288
PNO1 -2601 6496
PWP2 -202 5076
RBM28 -2634 3412
RCL1 -2883 6343
RIOK1 -1965 6498
RIOK2 -2842 1638
RIOK3 2889 3472
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPP14 118 2236
RPP21 -2049 2599
RPP25 -3481 5745
RPP30 -3480 668
RPP38 -3570 4780
RPP40 -4564 570
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
RRP1 -978 5200
RRP7A -1380 1582
RRP9 -3749 653
SENP3 -372 5394
SNU13 -3338 7054
TBL3 -235 5418
TEX10 -3806 1204
TSR1 -4435 6839
UBA52 -1041 -69
UTP15 -4147 5063
UTP18 1330 3357
UTP20 -3435 5085
UTP3 -1599 3926
UTP6 -3440 3932
WDR12 475 6794
WDR18 -1194 -1078
WDR3 -3009 -1387
WDR36 -2277 6601
WDR43 -4245 5510
WDR75 -4506 4614
XRN2 4157 -29



Signal Transduction

Signal Transduction
metric value
setSize 1169
pMANOVA 6.63e-25
p.adjustMANOVA 1.06e-22
s.dist 0.186
s.RNA 0.177
s.meth 0.056
p.RNA 8.88e-23
p.meth 0.00192




Top 20 genes
Gene RNA meth
FURIN 4429 7181
ATP6V0D1 4488 6936
CTSD 4618 6622
CLTC 4203 7259
PTPRJ 4193 7170
PRKCD 4519 6360
SOCS3 4419 6492
GNG5 4379 6512
MYO9B 4114 6777
MAPK1 4560 6099
RALB 4066 6833
CRK 4199 6598
KSR1 3863 7147
GRB2 4420 6241
GMIP 4567 5869
ECE1 4273 6249
SHB 4005 6644
PTPN6 4000 6542
ATP6V1C1 3831 6759
CAB39 3640 7109

Click HERE to show all gene set members

All member genes
RNA meth
AAMP -2190 7121
AATF 3154 5313
ABCA1 2550 -82
ABCG1 -2989 6771
ABHD12 -1193 5950
ABHD17A -1670 -550
ABHD17B -649 -676
ABHD6 3026 2533
ABI1 3644 3253
ABI2 -3635 -206
ABL1 1975 2469
ABR 4558 4699
ACTA2 456 4718
ACTB 4359 5447
ACTG1 3825 1603
ACTR2 3672 3844
ACTR3 3554 5952
ACVR1B 4625 -23
ACVR2A -4499 6957
ADAM10 4095 2760
ADAM17 4436 4155
ADAP1 3829 -1541
ADCY4 3163 -1006
ADCY7 1818 -981
ADCY9 -666 5439
ADGRE5 3420 -1470
ADM 4640 5105
ADORA2A 616 7186
ADORA3 2797 -1897
ADRB2 -1555 2808
AGO1 3338 7140
AGO2 1363 7196
AGO3 384 3465
AGRN -2908 2227
AHCTF1 -613 -864
AHCYL1 2934 2692
AKAP13 3202 4322
AKT1 1891 1109
AKT1S1 2817 1894
AKT2 781 5431
AP2A1 4623 -316
AP2M1 3567 3723
AP2S1 3281 6039
APBB1IP 4238 3821
APC 1393 1992
APH1A 1304 -119
APH1B 3617 6785
APP 2952 6623
ARAP1 4190 1485
ARAP2 -1468 5752
ARF6 1051 3741
ARHGAP1 4064 -524
ARHGAP10 -2801 6501
ARHGAP11A 1873 109
ARHGAP11B 2294 3318
ARHGAP12 -648 1249
ARHGAP15 -1743 4591
ARHGAP17 -2940 6872
ARHGAP18 3769 2306
ARHGAP19 3833 5728
ARHGAP21 952 6460
ARHGAP23 3215 6788
ARHGAP25 660 -568
ARHGAP26 4452 -247
ARHGAP27 4215 -1908
ARHGAP30 3306 2549
ARHGAP35 -327 2758
ARHGAP39 -2823 6949
ARHGAP5 -4420 6630
ARHGAP9 2946 6257
ARHGDIA 3065 6670
ARHGDIB 4060 1149
ARHGEF1 -500 4487
ARHGEF12 1442 5964
ARHGEF17 2607 1438
ARHGEF19 -3795 -87
ARHGEF2 3204 1182
ARHGEF26 678 6999
ARHGEF3 -3144 3996
ARHGEF39 -1984 -1564
ARHGEF7 -611 330
ARL2 -939 244
ARL4C -3599 2467
ARPC1B 4422 1709
ARPC2 3659 2292
ARPC3 3630 3208
ARPC5 4209 2611
ARRB1 1885 -1278
ARRB2 4237 2913
ASH2L 3680 3075
ATF1 1229 2989
ATN1 -1075 3096
ATP2A1 -104 5724
ATP2A2 3880 -1550
ATP2A3 577 1877
ATP6V0A1 4546 -1571
ATP6V0A2 -2629 6653
ATP6V0B 3723 5503
ATP6V0C 4483 2933
ATP6V0D1 4488 6936
ATP6V0E1 3450 1836
ATP6V0E2 -4253 -1327
ATP6V1A 3956 -1497
ATP6V1B2 3836 -1555
ATP6V1C1 3831 6759
ATP6V1D 4067 1096
ATP6V1E1 3280 4776
ATP6V1F 1531 -699
ATP6V1G2 -4149 3740
ATP6V1H 3287 2559
AURKB 1284 5274
AXIN1 -1579 -858
AXIN2 -3958 152
B4GALT1 3113 7043
B9D2 3082 1211
BAD 2906 4374
BAG4 3754 828
BAIAP2 -1012 2757
BAMBI 4307 3576
BAX 1666 1161
BCL2 -3030 7022
BCL2L1 1477 5970
BCL2L11 3447 5664
BCL9 -1247 4909
BCR 659 -1913
BIRC2 511 6626
BIRC3 -4591 4817
BIRC5 2356 1965
BMI1 -3702 -805
BMPR1A -2702 5829
BMPR2 2468 6822
BRAF 1030 -1526
BRAP 2450 -135
BRK1 1195 3071
BTRC -1864 -923
BUB1 668 67
BUB1B 64 1523
BUB3 -4382 1717
C3AR1 4610 -1596
CAB39 3640 7109
CAB39L 588 6420
CALM1 263 4502
CAMK2D -4530 -529
CAMK2G -152 6718
CAMK4 -4622 2759
CAMKK1 4181 5614
CAMKK2 4184 1010
CASP10 216 -1807
CASP3 2079 5691
CASP8 -1893 5448
CASP9 4537 3202
CAV1 249 4592
CBFB 863 5862
CBL 3732 1012
CBX4 2029 278
CBX6 2054 3612
CBX8 1089 4611
CBY1 -3791 3274
CCDC88C -2271 6961
CCNC -2266 4188
CCND1 -2034 1006
CCND3 4303 4156
CCNE1 -2341 5956
CCNK 2948 6593
CCNT1 -1783 1761
CCR1 3886 -1921
CCR10 -2297 2454
CCR7 -4309 7127
CD55 4493 1455
CDC14A -4618 3991
CDC14B -1778 1870
CDC20 1721 2639
CDC25C 1516 5507
CDC42 3449 856
CDC42EP3 3805 1427
CDC73 2258 5719
CDCA8 135 20
CDK1 -309 1888
CDK2 -1525 2965
CDK4 -4099 4919
CDK5 4361 3491
CDK5R1 202 7124
CDK8 795 5795
CDK9 1688 3144
CDKN1A 2283 2427
CDKN1B -1212 3367
CDON -3362 1466
CENPA 1149 72
CENPE 2579 -74
CENPF 1888 -400
CENPH -3774 84
CENPK -2349 1612
CENPL -1900 4694
CENPM -3286 6494
CENPN -50 1070
CENPO 1831 4161
CENPP -137 2080
CENPQ -2031 3793
CENPT -3406 4798
CENPU -259 433
CFL1 3970 1646
CFLAR 4113 3140
CHD1 138 1273
CHD3 -3189 6050
CHD4 -63 640
CHD8 2508 -916
CHEK1 -1742 51
CHN1 -2812 5361
CHUK 3354 1111
CIT 1425 5654
CKAP5 985 3384
CLASP1 2218 2114
CLASP2 -692 -77
CLIP1 4319 921
CLIP3 -3744 7133
CLTA 3106 -546
CLTB 3122 -918
CLTC 4203 7259
CNOT6L -3217 6262
CNR2 -2200 -1987
COL9A2 194 4444
CPT1A 2489 -1598
CREB1 -1458 1422
CREBBP 2340 892
CRK 4199 6598
CRKL 1455 5167
CSK 3371 4890
CSNK1A1 3363 4452
CSNK1E -2944 3000
CSNK1G2 873 2563
CSNK2A2 2821 5736
CSNK2B 1983 4743
CTBP1 800 6471
CTNNB1 3473 5070
CTNNBIP1 2756 1589
CTNND1 -33 -1709
CTSD 4618 6622
CUL1 -4005 -1192
CUL3 2435 -873
CUL5 -968 344
CXCL2 440 -1990
CXCR4 23 -1435
CXXC5 -2191 1039
CYBA 4037 2019
CYFIP1 4176 256
CYFIP2 -1121 6159
CYLD -4559 5706
CYP4V2 -2137 859
DAAM1 334 6127
DACT1 69 6080
DAGLB 4077 -302
DDX5 -3032 1804
DEPDC1B 1440 2392
DEPDC7 -2010 1621
DERL2 212 -1578
DGKA -4082 7033
DGKD 1369 4806
DGKE -3850 6507
DGKG 3273 4393
DGKH -1084 4127
DGKQ -641 3114
DGKZ -1261 -1315
DHRS3 -3652 1303
DHRS4 -119 635
DIAPH1 2862 2371
DISP2 -1570 5406
DLAT -758 3896
DLD 3345 3542
DLG1 -2579 358
DLG2 -429 -40
DLG4 3550 2607
DLGAP5 1638 -1160
DNAJB1 -2272 6095
DNAL4 -395 2609
DNM1 2517 1607
DNM2 3828 3063
DOCK7 -1420 2327
DRAP1 1677 5794
DSN1 -1681 -997
DTX4 3109 5144
DUSP1 2453 2023
DUSP10 174 4700
DUSP16 -3228 28
DUSP2 -2620 7009
DUSP3 2975 2260
DUSP4 -384 2494
DUSP5 -263 6280
DUSP6 -702 -1943
DUSP7 -732 722
DVL1 -2283 6368
DVL2 -3069 4884
DVL3 3827 161
DYNC1H1 416 4434
DYNC1I2 3229 693
DYNC1LI1 3337 3242
DYNC1LI2 2324 -185
DYNC2H1 -2279 5992
DYNLL1 1152 5151
DYNLL2 -1545 -924
E2F1 2365 3145
E2F3 3590 2135
E2F4 1569 1015
E2F5 -3126 4181
EBAG9 -3365 4461
ECE1 4273 6249
ECT2 1356 -1207
EED -2862 3088
EEF2K -3237 4092
EEPD1 439 3578
EFCAB7 -3160 -250
EGR1 -1170 1893
EGR2 -2296 4748
EIF4B -2753 5587
EIF4E 1167 6721
EIF4EBP1 1533 4398
EIF4G1 4177 5766
ELMO1 1982 939
ELMO2 4026 6110
EP300 3478 4901
EPAS1 4580 4596
EPN1 4367 5034
EPOR 4149 3155
EPS15 2111 -516
EPS15L1 2760 2728
ERBB2 -2008 4160
ERLEC1 1033 1240
ESR2 -3413 4784
ESRP2 85 -276
EVL -4381 7075
EZH2 -920 2695
F11R 2121 -1146
FABP5 2835 2233
FADD 3156 -329
FAM13A 2392 1054
FAM13B -2420 5114
FAS 1070 825
FASN -1486 4278
FBXW7 -1004 6667
FER -601 2567
FES 4502 -1638
FGD3 2357 1922
FGF9 -3638 997
FGFBP3 -1793 207
FGFRL1 -675 5867
FKBP1A 3631 1814
FKBP4 -2160 2679
FKBP5 4561 -681
FLT3LG -4600 6677
FMNL1 2966 3934
FMNL3 -3838 -90
FNTA -1333 694
FNTB 647 -1385
FOS 692 5647
FOSB -841 1975
FOSL1 3134 6224
FOXO1 -4458 3034
FOXO3 3816 5023
FRAT1 4121 5692
FRAT2 4118 4158
FRS2 -959 -882
FRS3 2713 6525
FSTL3 4559 5264
FURIN 4429 7181
FUZ 238 -944
FYN -1686 2793
FZD2 1735 2618
FZD3 -2857 6062
FZD5 4639 2664
FZD6 -3565 735
FZD7 -2336 2145
FZD8 -2070 2234
GAB2 4007 2390
GABBR1 -724 -1490
GALNT3 3300 -712
GAS8 -139 -619
GATA3 -4581 6274
GATAD2A 2102 189
GATAD2B 1474 5595
GDI2 2972 3343
GGA3 2518 671
GIPR -3140 -792
GLI1 1471 5203
GMIP 4567 5869
GNA12 -49 4303
GNA13 2128 3330
GNA15 4439 -1924
GNAI2 4151 3218
GNAI3 3381 2359
GNAL 247 3638
GNAQ 3913 -1832
GNAS 2180 -60
GNAT1 356 705
GNB1 4261 2799
GNB2 4032 1879
GNB4 3205 1335
GNB5 -1662 6256
GNG2 1513 6500
GNG3 1124 7142
GNG4 858 6856
GNG5 4379 6512
GNG7 -3064 -499
GNGT2 859 7120
GNRHR2 -1206 1263
GOLGA7 648 3104
GOPC -3517 2529
GPAM -3807 81
GPC2 -3081 7192
GPR132 1695 1930
GPR183 -4606 741
GPR35 3272 -1793
GPR65 2829 3227
GPR68 -2706 -285
GPS2 444 6830
GPSM2 2812 -92
GPSM3 2309 3761
GRAP2 -265 3631
GRB10 4652 3328
GRB2 4420 6241
GRIN2D 3552 3069
GRK4 81 5590
GRK5 -728 6891
GRK6 3169 3634
GSK3A 3876 2534
GSK3B 2685 4908
GTF2A1 204 1479
GTF2A2 1604 286
GTF2F1 2455 558
GTF2F2 2495 5307
HBEGF 646 -1007
HDAC1 -207 3287
HDAC10 413 4924
HDAC11 1672 6084
HDAC2 -1260 5864
HDAC3 1734 7116
HDAC4 4304 887
HDAC5 903 3068
HDAC7 1275 -487
HEBP1 2837 314
HGS 2818 4351
HHAT -2583 459
HIF1A 3440 2448
HNRNPF 839 5857
HNRNPH1 -3319 2373
HNRNPM 1748 2773
HRAS -2340 -823
HRH2 4642 -109
HSD17B1 -830 2592
HSP90AA1 -729 6210
HSP90AB1 -4016 -1226
HSPB1 -901 883
ICMT 465 2626
ID1 2910 5399
ID2 3560 1192
ID3 -3199 -55
IER3 2020 1545
IFT122 2110 3149
IFT140 -3407 5911
IFT172 -2394 -1247
IFT52 -575 320
IFT57 -234 1594
IGF1R 1912 -1422
IKBKB -510 -912
IKZF1 -991 5424
IL1RAP 3464 -1122
IL2RA -2715 6868
IL2RB -4098 7237
IL6R 2774 5066
IL6ST -361 1708
INCENP 590 5539
INPP5B -1498 -1535
INSR 3857 3558
IQGAP1 4024 587
IQGAP2 3573 3888
IRS1 -2666 4308
IRS2 3955 6152
ITCH 2362 4854
ITGA2 -1026 -260
ITGAV 2675 -370
ITGB3BP -3522 -83
ITPR1 -1851 1789
ITPR2 2474 -44
ITPR3 -2973 2189
ITSN1 4401 3959
JAK1 -2308 -283
JAK2 1159 6489
JUN -400 1283
JUNB 2048 5018
JUND -708 4243
KANK1 -3772 4095
KAT2A -4179 1343
KAT2B -105 4028
KAT5 1382 1952
KBTBD7 2876 -381
KCTD6 2053 -621
KDM1A -3046 5493
KDM1B 3526 -425
KDM3A -4553 -504
KDM4A 2954 3870
KDM4B 3898 1541
KDM4C -2062 6227
KHDRBS1 574 1137
KIDINS220 3496 3650
KIF14 1956 -596
KIF18A 75 3290
KIF2A -2268 4006
KIF2C 1020 -12
KIF3A -4235 6174
KIF5B 3295 4670
KLC1 2928 4386
KLC2 -2845 1505
KLC4 -2245 4367
KLHL12 4083 3615
KMT2D 2624 6495
KNTC1 -2681 429
KPNA2 66 4421
KRAS 2245 3139
KSR1 3863 7147
KTN1 229 -1506
LAMA2 -1632 6004
LAMB2 -214 1884
LAMTOR1 3714 -1589
LAMTOR2 3191 -1342
LAMTOR3 2265 957
LAMTOR4 1751 7000
LAMTOR5 3448 -881
LATS1 -1267 -841
LATS2 3302 103
LCK -4408 7246
LDLR 3941 1548
LEO1 197 4252
LEPR 1312 2863
LFNG 154 6685
LIMK1 3007 -1750
LIMK2 3246 116
LIN7B -705 992
LPAR2 3504 -1083
LPAR5 -976 6315
LPAR6 -3722 7276
LRIG1 -4545 -692
LRP10 3612 3887
LRP12 1731 5615
LRP5 -1398 -123
LRP6 -3051 1600
LRP8 3271 4757
LTB4R 4532 -1918
LTB4R2 1201 -1806
LYL1 3822 -1349
LYPLA1 3207 2159
MAD1L1 555 2466
MAD2L1 -2463 -200
MADD 394 -1304
MAF1 1605 6181
MAML1 2981 1442
MAML2 -3215 4627
MAML3 4174 3460
MAP2K1 4239 1533
MAP2K2 2556 6410
MAP2K5 804 3448
MAP3K11 4002 1270
MAP3K7 1566 -147
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
MAPK6 3063 257
MAPK7 3610 -244
MAPK8 -3916 4554
MAPKAP1 1834 5908
MAPKAPK2 3498 3265
MAPKAPK3 4597 2896
MAPRE1 3270 -441
MARK3 4168 3805
MBD3 -2156 6240
MDM2 2338 2095
MED1 -534 4473
MEF2A 3826 3013
MEF2D 1716 177
MEMO1 3289 1334
MEN1 -2694 1903
METAP1 -3036 -683
METAP2 -255 4485
MFNG -3156 6333
MIB1 -2050 3187
MIS12 -4133 4937
MKNK1 4108 1392
MKRN1 2433 2197
MKS1 -3471 4513
MLST8 -394 2258
MOB1B 1344 3562
MOV10 -2729 -1882
MST1 881 1923
MST1R -1259 -1885
MTA2 80 5579
MTA3 -3543 5162
MTMR4 1935 3784
MTOR -141 3900
MXD4 -1541 6707
MYB -86 -449
MYD88 4594 1945
MYH10 2136 5544
MYH9 3463 6146
MYL6 4089 2012
MYLIP -1584 2479
MYO9A -1558 6338
MYO9B 4114 6777
NAB1 469 5391
NAB2 -2294 3891
NAPEPLD -2667 5683
NBEA -3497 7003
NCBP1 -1093 5859
NCBP2 -4299 4777
NCF4 4148 -1941
NCK1 -3877 1018
NCK2 -480 1378
NCKAP1L 4619 -320
NCKIPSD -1667 667
NCOA2 2227 2432
NCOA3 2264 3815
NCOR1 3183 -530
NCOR2 4562 -1609
NCSTN 4654 1224
NDC80 -2742 4579
NDE1 1203 1067
NDEL1 3949 2477
NEDD4 3884 -1106
NEDD4L 2846 -1080
NEDD8 2980 -105
NELFB 829 -649
NET1 -2293 -1883
NF1 2485 -328
NF2 1372 1410
NFATC1 -2143 6947
NFKBIA 1525 6814
NLK 2043 -208
NLN 2505 6770
NMB -1921 -273
NMT1 3435 5713
NMT2 -4537 1226
NOS3 -3550 4048
NOTCH1 2941 6291
NOTCH4 3739 4962
NOXA1 -1526 -376
NPHP4 -41 4778
NR1H2 3489 6463
NR1H3 1154 6206
NR3C1 973 3509
NR4A1 -431 1085
NSL1 2751 2273
NSMAF -1318 3345
NTRK1 -1971 7049
NTSR1 3849 5436
NUDC -906 5032
NUF2 -51 1198
NUMB 4622 5039
NUP107 -3437 6301
NUP133 -2181 935
NUP160 -3890 1293
NUP37 126 3398
NUP43 -3608 6346
NUP85 -1192 4518
NUP98 1358 -747
OBSCN -3986 191
OPN3 1651 3803
OPRL1 4365 -1822
OS9 4487 -313
OTUD3 -2861 5747
OTUD7B -2426 42
OTULIN -597 6432
P2RY1 4641 3720
P2RY2 2670 -485
P4HB 4143 5718
PAFAH1B1 3062 6858
PAG1 2231 6279
PAK1 3814 2452
PAK2 3574 283
PAQR3 -786 2041
PARD6A -2303 4619
PARP1 -3863 3582
PCSK5 2248 -869
PDE1B 4090 -1314
PDE2A 1457 -1910
PDE3B -4123 3507
PDE4A 2884 -975
PDE4B -3498 -866
PDE4C 1700 -932
PDE4D 1793 1999
PDE6B -4014 1268
PDE6D 1876 4822
PDE7A -4465 5613
PDE7B 669 7263
PDE8A 2028 5316
PDHB 305 560
PDHX 538 4892
PDK1 -1265 1824
PDK2 -2346 3785
PDPK1 3218 346
PEA15 -1894 7145
PEBP1 -4410 4325
PELP1 -3840 2742
PFN1 3195 3814
PFN2 -3340 6353
PGF 1058 -1150
PHB -2116 4542
PHC1 -3966 -1213
PHC2 4569 4887
PHC3 -1507 4977
PHLPP1 2261 5441
PHLPP2 -4337 6881
PIK3AP1 4435 1373
PIK3CA 946 1470
PIK3CD 2671 6109
PIK3CG 3569 2051
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R3 995 3645
PIK3R4 -1326 2170
PIK3R5 1953 4483
PIN1 -43 4014
PIP4K2A 790 3045
PIP4K2B -2669 1071
PIP4K2C -716 223
PIP5K1A 1819 4436
PIP5K1C 2641 3895
PKN1 2682 6604
PKN2 -590 1740
PKN3 58 6035
PLB1 4655 -114
PLCB2 2360 903
PLCB3 4578 -1268
PLCG1 -4367 958
PLCG2 3848 2803
PLEKHG2 3810 4272
PLK1 1446 3514
PLXND1 4196 -1845
PMEPA1 -4115 7048
PMF1 243 6313
PML -714 4575
POFUT1 2930 3622
POLR2A 2412 4046
POLR2B -903 5563
POLR2C -520 6356
POLR2D -2238 -614
POLR2E 2119 3712
POLR2F 1375 509
POLR2G 1618 1604
POLR2H -2765 6299
POLR2I -1337 5657
POLR2K -1277 3853
POU2F1 2656 3909
PPARD -3709 -791
PPM1A 3367 -136
PPP1CA 2370 4238
PPP1CB 2691 -340
PPP1CC 1107 5379
PPP1R12A 3057 4510
PPP1R12B 1759 4895
PPP1R15A 738 829
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5A 3674 -230
PPP2R5B 3304 -286
PPP2R5C -1671 7074
PPP2R5D 2123 3470
PPP2R5E -4 1402
PPP3CA 1951 5980
PPP3CB 2717 4044
PPP3CC -4094 2384
PPP3R1 2516 2945
PPP5C -1013 5721
PRC1 1301 4462
PRDM4 -2179 6116
PREX1 4180 5229
PRKAA1 884 607
PRKAB1 2075 -840
PRKAB2 -2556 3091
PRKACA 4634 890
PRKACB -4510 1712
PRKAG1 3050 -1055
PRKAG2 -201 1021
PRKAR1A 4338 -432
PRKAR1B 1934 1230
PRKAR2A 3132 -874
PRKCA -1148 6894
PRKCB 3491 4964
PRKCD 4519 6360
PRKCE 2768 -1185
PRKCH -4342 2578
PRKCI -1890 1662
PRKCQ -4282 4208
PRKCZ -2913 -1376
PRMT1 -3864 2118
PROK2 4410 -1991
PRR5 -2935 -347
PSAP 3637 628
PSEN1 4223 4955
PSEN2 -2281 -162
PSENEN 2445 4980
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PTBP1 -1702 815
PTCH1 -1456 5608
PTCH2 -1950 -566
PTEN 3783 4815
PTGER2 988 -850
PTGER4 -1371 5866
PTGES3 -943 4287
PTK2 -81 -475
PTK2B 4451 4529
PTPN1 4210 699
PTPN11 2499 5062
PTPN12 3373 -982
PTPN18 4484 3436
PTPN2 3642 181
PTPN6 4000 6542
PTPN7 -570 2323
PTPRA 2152 6358
PTPRJ 4193 7170
PTPRU 2459 -1728
PXN 3736 -814
PYGO2 -4034 6530
QRFP 1110 -1964
RAB4A 480 559
RAB4B 3084 4688
RAB6A 3957 3323
RAC1 4404 5541
RAC2 2815 4577
RAC3 -586 827
RACGAP1 2182 4089
RAD21 -782 5118
RAF1 3220 6573
RALA -2065 2302
RALB 4066 6833
RALBP1 3083 5392
RALGDS -3164 6406
RANBP10 1007 5496
RANBP2 -757 5165
RANBP9 2528 884
RANGAP1 -3882 3626
RAP1A 3123 6569
RAP1B 3135 5968
RAPGEF1 1580 6445
RARA 4270 2132
RARG -2176 297
RASA1 1788 3434
RASA2 -74 2632
RASA3 -4225 187
RASAL1 -1471 5685
RASAL3 -3093 2544
RASGRP1 -4340 5888
RASGRP2 -3066 -413
RASGRP3 -3423 760
RBBP4 -1544 4061
RBBP5 -425 2829
RBCK1 2276 -510
RBL1 -2744 5256
RBPJ 4163 1033
RBX1 2032 5883
RCC2 913 1985
RCE1 -1527 3297
RCOR1 4284 -178
RDH10 -5 262
RDH11 1870 4047
RDH13 -671 -1151
RDH14 -4507 1087
REEP3 1594 -686
REEP4 4029 4543
REEP5 2374 4474
REEP6 -4412 3374
RELA -360 4333
REST 1134 1286
RETSAT 852 1509
RGL1 4405 3381
RGL2 2856 4879
RGS1 -2110 4458
RGS10 -254 1143
RGS12 162 4990
RGS14 2015 1881
RGS16 -1528 2518
RGS19 3895 -154
RGS2 2792 3106
RGS3 3252 7122
RHEB 2587 6311
RHOA 3965 4033
RHOB 2718 2346
RHOBTB2 -2516 2104
RHOF -3727 6478
RHOG 4253 3664
RHOH -4180 5999
RHOQ 1613 -160
RHOT1 4536 5576
RHOT2 -1416 5894
RHPN1 -4248 852
RICTOR -2640 2833
RING1 -1660 1003
RIT1 4354 2694
RNF111 1846 6049
RNF146 4444 1611
RNF2 368 2513
RNF31 -863 3198
RNF41 4019 4402
ROCK1 3502 2732
RPGRIP1L -4066 2731
RPS27A -4269 2589
RPS6 -4216 361
RPS6KA1 4497 -1859
RPS6KA2 1476 2117
RPS6KA5 -4234 1991
RPS6KB2 502 4805
RPTOR -1341 5596
RRAGA 3206 6806
RRAGC 1583 5284
RRAGD 3274 -1656
RTN4 4539 2901
RTP4 -1910 -417
RUNX1 4116 193
RUNX3 -2362 6760
RUVBL1 -3041 4751
RYK -4311 4958
S1PR1 -1875 6791
S1PR2 -2392 3081
S1PR4 2266 5358
SAG 2101 -261
SAV1 -896 -1156
SCAI -2539 1276
SCD 2700 -1082
SCMH1 -4153 95
SCRIB 428 -1418
SDC4 2632 2364
SEC13 2199 6211
SEH1L -4328 3577
SEL1L 3003 4058
SFN 270 -1779
SFPQ -2030 3947
SGK1 -2329 -1194
SH2B1 -2743 1436
SH2B3 2478 3851
SH2D2A -2019 6509
SH3GL1 3225 6040
SHARPIN 2592 4878
SHB 4005 6644
SHC1 3684 3205
SHOC2 2762 34
SIRT6 2625 6645
SKA2 -472 2113
SKI -2429 2897
SKIL 2470 3946
SKP1 -1442 2680
SLC38A9 1908 6117
SMAD1 4645 206
SMAD2 2413 1865
SMAD3 -3734 -363
SMAD4 -2091 -1925
SMAD5 -1321 221
SMAD6 4249 5259
SMAD7 100 1420
SMARCA4 3223 6792
SMC3 -1506 623
SMPD2 780 6784
SMPD3 -2987 7226
SMURF1 1871 6934
SMURF2 -2759 3523
SNW1 1711 2517
SOCS1 1954 4130
SOCS3 4419 6492
SOS1 -1564 -1986
SOS2 3721 3699
SOX4 2798 4439
SP1 3396 4865
SPC24 1279 3603
SPDL1 -4352 480
SPOP -712 39
SPOPL 3006 -1205
SPPL2A 3699 1613
SPPL2B -2337 4261
SPRED1 1438 6065
SPRED2 4200 5462
SPRED3 382 5938
SPRY1 -719 2310
SPRY2 1217 1690
SPTAN1 -4215 -407
SPTBN1 -3763 3657
SPTBN5 914 2256
SQSTM1 -377 658
SRC -2136 -1476
SREBF1 387 2475
SRF 3298 2816
SRGAP1 3976 -15
SRGAP3 385 -351
ST3GAL3 -1399 5837
ST3GAL4 3906 -1351
ST3GAL6 1264 6719
STAG1 -1529 5283
STAM 398 6491
STAM2 2689 3301
STARD13 2104 7249
STAT1 -4254 4970
STAT3 3772 4995
STAT5A 2951 -1545
STAT5B 2832 1495
STAT6 3358 3854
STK11 -574 750
STK3 3936 265
STK4 591 -11
STMN1 -3082 3009
STRADA 2323 3716
STRADB 1723 1425
STRAP 1702 5452
STRN 2310 6485
STUB1 -602 2320
SUFU 4511 3621
SYDE2 -4324 6281
SYK 4235 431
SYNGAP1 -3633 1191
SYVN1 813 -846
TAB2 605 6401
TACC3 3402 5485
TAGAP -4573 3486
TAOK1 2715 7113
TAX1BP1 2464 1037
TBL1XR1 1687 2633
TCF12 501 -542
TCF7 -4620 6951
TCF7L2 4387 1660
TCIRG1 4397 1353
TEC 3744 170
TERT -1961 7281
TFDP1 3248 2953
TFDP2 -3389 -1478
TGFA 4325 4632
TGFB1 2241 3769
TGFBR1 1602 -1264
TGFBR2 1403 2870
TGIF1 -2962 -390
TGIF2 -4030 -1905
THBS3 2314 -662
THEM4 -4605 809
TIA1 -2132 2854
TIAL1 -1748 5521
TIAM2 765 -1147
TJP2 3860 4717
TLE2 -4558 1969
TLE3 4495 3113
TLE4 3995 5138
TLN1 4172 -983
TLR9 -1039 7204
TMED2 2394 5946
TMED5 2919 1678
TNF -1302 -526
TNFAIP3 -891 6105
TNFRSF10A -1831 2821
TNFRSF10B 2678 -670
TNFRSF10D 2388 3086
TNFRSF1A 4400 -1548
TNFSF10 611 369
TNKS -609 4477
TNKS2 924 2960
TNRC6A -777 5197
TNRC6B -251 7059
TP53 -4050 2709
TRADD -2711 5248
TRAF1 -4162 6215
TRAF2 -3445 5765
TRAF6 957 -71
TRIB3 207 3767
TRIM27 3618 5498
TRIM33 21 6680
TRIO 1317 6818
TRRAP -967 6328
TSC1 -336 4696
TSC2 775 3951
TTC21B -2916 3389
TULP3 -3805 3709
TYK2 3852 4072
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
UBE2D1 3774 2741
UBE2D3 3445 3005
UBE2M 2900 2052
UCHL5 -2318 2394
UHMK1 -482 4668
USF1 1801 3193
USF2 1988 1718
USP13 -1135 2905
USP15 1381 4187
USP21 -2234 -293
USP34 -210 1573
USP4 4141 -254
USP7 2187 3259
USP8 2773 4109
VAPA 3892 4246
VAV1 3798 5834
VAV2 803 4134
VAV3 3247 -685
VCL 2594 3614
VCP 3034 1908
VEGFA 2025 87
VIPR1 -3102 5973
VPS26A 2851 4070
VPS29 1937 688
VPS35 2985 -1447
VRK3 2298 2903
WASF1 4564 -830
WASF2 4427 -134
WASL 522 4645
WDR19 -3620 -150
WDR35 -2259 -219
WDR83 2132 5497
WIPF1 919 -784
WIPF2 3524 -1018
WNT1 -2641 2325
WNT2B 1017 3566
WWOX -3828 4712
WWP1 -4551 479
WWP2 4309 2916
XPO1 -925 6847
YBX1 1836 6425
YES1 -1029 5198
YWHAB 2512 2152
YWHAE 3796 1288
YWHAG 4225 1919
YWHAH 4276 -1276
YWHAQ -1174 3225
YWHAZ 2353 4294
YY1 -1642 1468
ZDHHC21 -2969 427
ZDHHC7 3256 4796
ZFYVE16 3182 4517
ZFYVE9 -4371 3529
ZNF217 1306 2921
ZNRF3 -2412 3859
ZW10 -339 -591
ZWILCH -1781 835
ZWINT -1685 6104



Membrane Trafficking

Membrane Trafficking
metric value
setSize 436
pMANOVA 1.15e-23
p.adjustMANOVA 1.6e-21
s.dist 0.29
s.RNA 0.29
s.meth -0.00233
p.RNA 1.1e-24
p.meth 0.934




Top 20 genes
Gene RNA meth
CPD 4395 -1840
CTSZ 4030 -1980
ARF1 4345 -1821
GALNT2 4471 -1749
IGF2R 4158 -1659
RIN1 4557 -1288
FTL 4047 -1426
YWHAH 4276 -1276
KIF3C 3608 -1430
GOLGA2 3731 -1361
PICALM 4100 -1233
CCZ1 2414 -1870
VPS37B 2793 -1611
TBC1D1 3927 -1099
CLINT1 2116 -1929
BLOC1S1 4386 -817
VPS25 3656 -962
PPP6R1 3172 -1034
PRKAG1 3050 -1055
SNX18 4555 -690

Click HERE to show all gene set members

All member genes
RNA meth
AAK1 -1423 2550
ACBD3 933 201
ACTR10 2879 4868
ACTR1A 4039 1932
ACTR2 3672 3844
ACTR3 3554 5952
ADRB2 -1555 2808
AGFG1 4316 4595
AGPAT3 3024 637
AKT1 1891 1109
AKT2 781 5431
ALS2CL -4562 2557
ANK1 2094 947
ANK3 -2638 1579
ANKRD27 2367 2102
ANKRD28 -2013 548
AP1B1 4393 5783
AP1G1 2519 2214
AP1G2 -1917 -226
AP1M1 3701 1777
AP1S3 -992 1942
AP2A1 4623 -316
AP2M1 3567 3723
AP2S1 3281 6039
AP3B1 3362 3782
AP3S1 2945 6511
AP4B1 -219 1635
AP4E1 1977 1918
AP4M1 2540 6150
AP4S1 -1795 6583
APP 2952 6623
ARCN1 2361 -399
ARF1 4345 -1821
ARF3 3661 274
ARF4 3856 4620
ARF5 3186 -939
ARF6 1051 3741
ARFGAP1 429 6821
ARFGAP3 2679 724
ARFIP2 -2058 -113
ARFRP1 -2073 6546
ARL1 -720 2168
ARPC2 3659 2292
ARPC3 3630 3208
ARPC5 4209 2611
ARRB1 1885 -1278
ARRB2 4237 2913
ASPSCR1 -2369 5824
BET1 -2521 1788
BET1L -1329 4145
BICD1 -1418 2613
BICD2 3742 556
BIN1 -4252 617
BLOC1S1 4386 -817
BLOC1S3 -441 6143
BLOC1S6 419 4818
BNIP1 -2537 4079
C2CD5 -1431 6927
CALM1 263 4502
CAPZA1 3861 999
CAPZA2 3520 4667
CAPZB 3889 -308
CBL 3732 1012
CCZ1 2414 -1870
CD3D -3812 7274
CD4 -2816 909
CD55 4493 1455
CD59 1662 -1684
CENPE 2579 -74
CHMP2A 4044 5362
CHMP2B 1863 1684
CHMP3 3628 3694
CHMP4A 1622 4138
CHMP4B 4150 5512
CHMP5 4056 4370
CHMP6 2880 2702
CHMP7 -4236 6064
CLINT1 2116 -1929
CLTA 3106 -546
CLTB 3122 -918
CLTC 4203 7259
CLTCL1 3815 4511
CNIH1 487 6434
COG1 -3368 922
COG2 -2270 -1012
COG3 -1860 755
COG4 2622 645
COG5 -65 2084
COG6 -2374 3686
COG7 3564 3161
COG8 -437 2377
COPA 4310 5455
COPB1 3055 2637
COPB2 3505 3476
COPE 3047 434
COPS2 964 6456
COPS3 1532 1714
COPS4 218 5826
COPS5 1335 3236
COPS6 30 782
COPS7A 3293 -66
COPS7B -1661 5099
COPS8 -3567 -1152
COPZ1 1087 97
COPZ2 -2063 -1672
CPD 4395 -1840
CSNK1D 2488 3046
CTSC 3824 1311
CTSZ 4030 -1980
CUX1 4609 4795
CYTH1 -4239 6595
CYTH2 737 2352
CYTH3 -1313 -968
CYTH4 3762 3823
DCTN2 4315 -727
DCTN3 2651 2751
DCTN4 4328 4417
DCTN5 -160 6060
DCTN6 2977 6882
DENND1A 2538 3969
DENND1B -1255 7221
DENND1C -461 3359
DENND2C 3389 875
DENND2D -4369 7012
DENND3 4298 2137
DENND4A -1502 2736
DENND4B 2687 1004
DENND5A 3653 1439
DENND6A 1515 280
DNM1 2517 1607
DNM2 3828 3063
DTNBP1 160 284
DVL2 -3069 4884
DYNC1H1 416 4434
DYNC1I2 3229 693
DYNC1LI1 3337 3242
DYNC1LI2 2324 -185
DYNLL1 1152 5151
DYNLL2 -1545 -924
EPN1 4367 5034
EPN2 -73 2946
EPS15 2111 -516
EPS15L1 2760 2728
EXOC1 2755 6223
EXOC2 -2094 5978
EXOC3 2554 3757
EXOC4 2694 1729
EXOC5 442 6716
EXOC6 4136 2017
EXOC7 3140 2374
EXOC8 1101 6708
FCHO1 -1639 6034
FCHO2 2778 -593
FNBP1 1653 2510
FTH1 2313 3117
FTL 4047 -1426
GABARAP 2757 4039
GABARAPL2 2931 2948
GAK 3346 6665
GALNT2 4471 -1749
GAPVD1 3245 5351
GBF1 2006 4985
GCC1 1405 -1635
GCC2 -2645 3257
GDI2 2972 3343
GGA1 1689 4229
GGA2 -1201 4335
GGA3 2518 671
GJD3 4320 -251
GNS 4646 4429
GOLGA1 3118 1794
GOLGA2 3731 -1361
GOLGA4 -644 775
GOLGA5 2921 -549
GOLGB1 -1140 5355
GOLIM4 3799 2148
GORASP1 3039 -281
GOSR1 -399 -852
GOSR2 787 5880
GPS1 -900 6190
GRB2 4420 6241
HBEGF 646 -1007
HGS 2818 4351
HIP1 4256 6522
HIP1R -4113 -20
HPS1 2766 804
HPS4 -3112 4213
IGF2R 4158 -1659
ITSN1 4401 3959
ITSN2 1957 -585
KDELR1 3788 4935
KDELR2 2828 1832
KIAA0319 1397 2703
KIF11 1038 1895
KIF13B 3335 2528
KIF15 127 6309
KIF16B -1472 5965
KIF18A 75 3290
KIF18B 1780 5532
KIF1B 4248 1220
KIF20A 1510 1403
KIF20B -1753 4534
KIF21A -2976 -346
KIF21B 951 2388
KIF22 -4500 6183
KIF23 1200 805
KIF26B -3124 -1903
KIF27 1319 6076
KIF2A -2268 4006
KIF2C 1020 -12
KIF3A -4235 6174
KIF3B 1598 2018
KIF3C 3608 -1430
KIF5B 3295 4670
KIF6 834 2531
KIF9 2317 2418
KIFAP3 -995 -68
KIFC1 681 1767
KIFC2 -1378 2527
KLC1 2928 4386
KLC2 -2845 1505
KLC4 -2245 4367
LDLR 3941 1548
LDLRAP1 -4570 4896
LMAN1 -3797 5995
LMAN2 3597 6266
LMAN2L 797 1715
LNPEP -522 2406
M6PR -1467 5979
MADD 394 -1304
MAN1A1 4431 1559
MAN1A2 -543 3421
MAN1C1 -4535 145
MAN2A1 -1576 2421
MAN2A2 3764 2485
MCFD2 2059 2397
MIA3 -1636 4042
MON1A -38 1152
MON1B 3998 1931
MVB12A 2841 357
MYH9 3463 6146
MYO6 -1443 1793
NAA30 -3484 2646
NAA35 -3326 4714
NAA38 3308 -541
NAPA 2576 3102
NAPB 239 2662
NAPG 2087 2684
NBAS 523 3732
NECAP1 956 3774
NECAP2 -722 3097
NEDD8 2980 -105
OPTN -3637 -509
PACSIN1 -4040 -1068
PACSIN2 3981 6931
PAFAH1B1 3062 6858
PAFAH1B2 2581 2435
PAFAH1B3 -1328 6671
PICALM 4100 -1233
PIP5K1C 2641 3895
PLA2G6 -3342 826
PLIN3 4612 23
POLG -658 3652
PPP6C 1747 6979
PPP6R1 3172 -1034
PPP6R3 1368 -1719
PRKAB1 2075 -840
PRKAB2 -2556 3091
PRKAG1 3050 -1055
PRKAG2 -201 1021
PUM1 2504 6662
RAB10 4485 3067
RAB11A 2969 2440
RAB11B 1143 3899
RAB12 17 -468
RAB14 2619 -378
RAB18 2483 2764
RAB1A 4010 6419
RAB1B 3988 4467
RAB27A 3787 222
RAB30 -4174 2925
RAB33B 1996 5180
RAB35 2447 905
RAB3A 2502 4348
RAB3GAP1 1547 3219
RAB3GAP2 2551 3837
RAB3IP 22 678
RAB43 1830 5468
RAB4A 480 559
RAB5A 2871 3958
RAB5B 3004 1957
RAB5C 3866 797
RAB6A 3957 3323
RAB7A 4110 -124
RAB8A 2807 1826
RAB8B 2955 1101
RABEP1 -2475 6121
RABEPK 2040 5565
RABGAP1 1460 6385
RABGEF1 3005 3772
RAC1 4404 5541
RACGAP1 2182 4089
RALA -2065 2302
RALGAPA2 4285 -284
RALGAPB 143 3710
REPS1 41 6314
RGP1 2372 -1039
RHOBTB3 -32 1297
RHOQ 1613 -160
RIC1 2763 6857
RIN1 4557 -1288
RINL -646 6131
RINT1 -3883 3453
RPS27A -4269 2589
SAR1B 2728 3060
SBF1 -1870 3727
SCARB2 3951 3550
SCOC -3708 2228
SEC13 2199 6211
SEC16A 3331 4812
SEC22A -3026 2581
SEC22C -1101 5700
SEC23A 2702 1833
SEC23IP 177 1231
SEC24A 3575 4762
SEC24B 2183 -13
SEC24C 2332 -336
SEC24D 4409 1527
SEC31A 1591 2523
SFN 270 -1779
SH3GL1 3225 6040
SNAP23 3209 -471
SNAP29 3729 3148
SNAPIN 2719 1354
SNF8 2422 5287
SNX18 4555 -690
SNX2 2853 186
SPTAN1 -4215 -407
SPTBN1 -3763 3657
SPTBN5 914 2256
SRC -2136 -1476
STAM 398 6491
STAM2 2689 3301
STX10 3748 5277
STX16 833 1974
STX17 -3674 -218
STX18 2849 2718
STX4 2105 1609
STX5 3382 5926
STX6 3023 -252
STXBP3 2813 199
SURF4 3260 3679
SYNJ1 4109 2804
SYNJ2 -3998 -505
SYS1 -1056 4319
SYT11 2707 4051
SYTL1 -2430 -620
TBC1D1 3927 -1099
TBC1D10A -1489 5672
TBC1D10B 4078 6337
TBC1D10C -3594 6912
TBC1D13 2761 4704
TBC1D14 4432 30
TBC1D15 -550 5333
TBC1D17 -2016 6199
TBC1D2 4388 647
TBC1D20 747 1409
TBC1D24 1774 4060
TBC1D4 -4610 4593
TBC1D7 2603 5951
TFRC 1670 -131
TGFA 4325 4632
TGOLN2 4204 5919
TMED10 -974 3393
TMED2 2394 5946
TMED3 1979 5786
TMED7 2142 -959
TMED9 3384 1623
TMEM115 2240 -632
TMF1 1215 1642
TOR1A 3513 5481
TOR1B 3571 -606
TPD52 -3973 5618
TRAPPC1 3635 5233
TRAPPC10 117 6987
TRAPPC12 3557 7029
TRAPPC13 -297 7206
TRAPPC2L -945 1131
TRAPPC3 2092 -470
TRAPPC4 -960 1676
TRAPPC5 1256 29
TRAPPC6A -4241 -1706
TRAPPC6B 557 1818
TRAPPC8 2661 59
TRAPPC9 2575 -816
TRIP11 -951 5856
TSC1 -336 4696
TSC2 775 3951
TSG101 3030 -488
TXNDC5 -1496 -1873
UBA52 -1041 -69
UBAP1 4169 5038
UBB 509 5059
UBC 2477 3220
UBQLN1 1803 2747
ULK1 4375 1
USE1 -1903 654
USO1 1288 3424
USP6NL -427 5625
VAMP2 -3963 -1239
VAMP3 3838 619
VAMP4 -190 1517
VAMP8 592 868
VPS25 3656 -962
VPS28 73 6115
VPS36 -1430 1902
VPS37A 2775 3939
VPS37B 2793 -1611
VPS37C 4268 4035
VPS45 -153 3197
VPS4A 331 3112
VPS51 -3377 -1323
VPS52 119 5049
VPS53 2676 4288
VPS54 2045 -1404
VTA1 2056 3950
VTI1A 3327 3539
WASL 522 4645
YKT6 2709 3314
YWHAB 2512 2152
YWHAE 3796 1288
YWHAG 4225 1919
YWHAH 4276 -1276
YWHAQ -1174 3225
YWHAZ 2353 4294
ZW10 -339 -591



Vesicle-mediated transport

Vesicle-mediated transport
metric value
setSize 442
pMANOVA 2.47e-23
p.adjustMANOVA 3.07e-21
s.dist 0.285
s.RNA 0.285
s.meth 0.00404
p.RNA 2.85e-24
p.meth 0.886




Top 20 genes
Gene RNA meth
CLTC 4203 7259
HIP1 4256 6522
PACSIN2 3981 6931
GRB2 4420 6241
TBC1D10B 4078 6337
RAB1A 4010 6419
AP1B1 4393 5783
TRAPPC12 3557 7029
TGOLN2 4204 5919
RAC1 4404 5541
COPA 4310 5455
CHMP4B 4150 5512
LMAN2 3597 6266
GAK 3346 6665
CUX1 4609 4795
EPN1 4367 5034
CHMP2A 4044 5362
MYH9 3463 6146
ACTR3 3554 5952
UBAP1 4169 5038

Click HERE to show all gene set members

All member genes
RNA meth
AAK1 -1423 2550
ACBD3 933 201
ACTR10 2879 4868
ACTR1A 4039 1932
ACTR2 3672 3844
ACTR3 3554 5952
ADRB2 -1555 2808
AGFG1 4316 4595
AGPAT3 3024 637
AKT1 1891 1109
AKT2 781 5431
ALS2CL -4562 2557
ANK1 2094 947
ANK3 -2638 1579
ANKRD27 2367 2102
ANKRD28 -2013 548
AP1B1 4393 5783
AP1G1 2519 2214
AP1G2 -1917 -226
AP1M1 3701 1777
AP1S3 -992 1942
AP2A1 4623 -316
AP2M1 3567 3723
AP2S1 3281 6039
AP3B1 3362 3782
AP3S1 2945 6511
AP4B1 -219 1635
AP4E1 1977 1918
AP4M1 2540 6150
AP4S1 -1795 6583
APP 2952 6623
ARCN1 2361 -399
ARF1 4345 -1821
ARF3 3661 274
ARF4 3856 4620
ARF5 3186 -939
ARF6 1051 3741
ARFGAP1 429 6821
ARFGAP3 2679 724
ARFIP2 -2058 -113
ARFRP1 -2073 6546
ARL1 -720 2168
ARPC2 3659 2292
ARPC3 3630 3208
ARPC5 4209 2611
ARRB1 1885 -1278
ARRB2 4237 2913
ASPSCR1 -2369 5824
BET1 -2521 1788
BET1L -1329 4145
BICD1 -1418 2613
BICD2 3742 556
BIN1 -4252 617
BLOC1S1 4386 -817
BLOC1S3 -441 6143
BLOC1S6 419 4818
BNIP1 -2537 4079
C2CD5 -1431 6927
CALM1 263 4502
CALR 2667 5714
CAPZA1 3861 999
CAPZA2 3520 4667
CAPZB 3889 -308
CBL 3732 1012
CCZ1 2414 -1870
CD3D -3812 7274
CD4 -2816 909
CD55 4493 1455
CD59 1662 -1684
CENPE 2579 -74
CHMP2A 4044 5362
CHMP2B 1863 1684
CHMP3 3628 3694
CHMP4A 1622 4138
CHMP4B 4150 5512
CHMP5 4056 4370
CHMP6 2880 2702
CHMP7 -4236 6064
CLINT1 2116 -1929
CLTA 3106 -546
CLTB 3122 -918
CLTC 4203 7259
CLTCL1 3815 4511
CNIH1 487 6434
COG1 -3368 922
COG2 -2270 -1012
COG3 -1860 755
COG4 2622 645
COG5 -65 2084
COG6 -2374 3686
COG7 3564 3161
COG8 -437 2377
COPA 4310 5455
COPB1 3055 2637
COPB2 3505 3476
COPE 3047 434
COPS2 964 6456
COPS3 1532 1714
COPS4 218 5826
COPS5 1335 3236
COPS6 30 782
COPS7A 3293 -66
COPS7B -1661 5099
COPS8 -3567 -1152
COPZ1 1087 97
COPZ2 -2063 -1672
CPD 4395 -1840
CSNK1D 2488 3046
CTSC 3824 1311
CTSZ 4030 -1980
CUX1 4609 4795
CYTH1 -4239 6595
CYTH2 737 2352
CYTH3 -1313 -968
CYTH4 3762 3823
DCTN2 4315 -727
DCTN3 2651 2751
DCTN4 4328 4417
DCTN5 -160 6060
DCTN6 2977 6882
DENND1A 2538 3969
DENND1B -1255 7221
DENND1C -461 3359
DENND2C 3389 875
DENND2D -4369 7012
DENND3 4298 2137
DENND4A -1502 2736
DENND4B 2687 1004
DENND5A 3653 1439
DENND6A 1515 280
DNM1 2517 1607
DNM2 3828 3063
DTNBP1 160 284
DVL2 -3069 4884
DYNC1H1 416 4434
DYNC1I2 3229 693
DYNC1LI1 3337 3242
DYNC1LI2 2324 -185
DYNLL1 1152 5151
DYNLL2 -1545 -924
EPN1 4367 5034
EPN2 -73 2946
EPS15 2111 -516
EPS15L1 2760 2728
EXOC1 2755 6223
EXOC2 -2094 5978
EXOC3 2554 3757
EXOC4 2694 1729
EXOC5 442 6716
EXOC6 4136 2017
EXOC7 3140 2374
EXOC8 1101 6708
FCHO1 -1639 6034
FCHO2 2778 -593
FNBP1 1653 2510
FTH1 2313 3117
FTL 4047 -1426
GABARAP 2757 4039
GABARAPL2 2931 2948
GAK 3346 6665
GALNT2 4471 -1749
GAPVD1 3245 5351
GBF1 2006 4985
GCC1 1405 -1635
GCC2 -2645 3257
GDI2 2972 3343
GGA1 1689 4229
GGA2 -1201 4335
GGA3 2518 671
GJD3 4320 -251
GNS 4646 4429
GOLGA1 3118 1794
GOLGA2 3731 -1361
GOLGA4 -644 775
GOLGA5 2921 -549
GOLGB1 -1140 5355
GOLIM4 3799 2148
GORASP1 3039 -281
GOSR1 -399 -852
GOSR2 787 5880
GPS1 -900 6190
GRB2 4420 6241
HBEGF 646 -1007
HGS 2818 4351
HIP1 4256 6522
HIP1R -4113 -20
HPS1 2766 804
HPS4 -3112 4213
HSP90AA1 -729 6210
HSP90B1 -436 2127
HSPH1 -3516 5508
HYOU1 978 3849
IGF2R 4158 -1659
ITSN1 4401 3959
ITSN2 1957 -585
KDELR1 3788 4935
KDELR2 2828 1832
KIAA0319 1397 2703
KIF11 1038 1895
KIF13B 3335 2528
KIF15 127 6309
KIF16B -1472 5965
KIF18A 75 3290
KIF18B 1780 5532
KIF1B 4248 1220
KIF20A 1510 1403
KIF20B -1753 4534
KIF21A -2976 -346
KIF21B 951 2388
KIF22 -4500 6183
KIF23 1200 805
KIF26B -3124 -1903
KIF27 1319 6076
KIF2A -2268 4006
KIF2C 1020 -12
KIF3A -4235 6174
KIF3B 1598 2018
KIF3C 3608 -1430
KIF5B 3295 4670
KIF6 834 2531
KIF9 2317 2418
KIFAP3 -995 -68
KIFC1 681 1767
KIFC2 -1378 2527
KLC1 2928 4386
KLC2 -2845 1505
KLC4 -2245 4367
LDLR 3941 1548
LDLRAP1 -4570 4896
LMAN1 -3797 5995
LMAN2 3597 6266
LMAN2L 797 1715
LNPEP -522 2406
M6PR -1467 5979
MADD 394 -1304
MAN1A1 4431 1559
MAN1A2 -543 3421
MAN1C1 -4535 145
MAN2A1 -1576 2421
MAN2A2 3764 2485
MCFD2 2059 2397
MIA3 -1636 4042
MON1A -38 1152
MON1B 3998 1931
MVB12A 2841 357
MYH9 3463 6146
MYO6 -1443 1793
NAA30 -3484 2646
NAA35 -3326 4714
NAA38 3308 -541
NAPA 2576 3102
NAPB 239 2662
NAPG 2087 2684
NBAS 523 3732
NECAP1 956 3774
NECAP2 -722 3097
NEDD8 2980 -105
OPTN -3637 -509
PACSIN1 -4040 -1068
PACSIN2 3981 6931
PAFAH1B1 3062 6858
PAFAH1B2 2581 2435
PAFAH1B3 -1328 6671
PICALM 4100 -1233
PIP5K1C 2641 3895
PLA2G6 -3342 826
PLIN3 4612 23
POLG -658 3652
PPP6C 1747 6979
PPP6R1 3172 -1034
PPP6R3 1368 -1719
PRKAB1 2075 -840
PRKAB2 -2556 3091
PRKAG1 3050 -1055
PRKAG2 -201 1021
PUM1 2504 6662
RAB10 4485 3067
RAB11A 2969 2440
RAB11B 1143 3899
RAB12 17 -468
RAB14 2619 -378
RAB18 2483 2764
RAB1A 4010 6419
RAB1B 3988 4467
RAB27A 3787 222
RAB30 -4174 2925
RAB33B 1996 5180
RAB35 2447 905
RAB3A 2502 4348
RAB3GAP1 1547 3219
RAB3GAP2 2551 3837
RAB3IP 22 678
RAB43 1830 5468
RAB4A 480 559
RAB5A 2871 3958
RAB5B 3004 1957
RAB5C 3866 797
RAB6A 3957 3323
RAB7A 4110 -124
RAB8A 2807 1826
RAB8B 2955 1101
RABEP1 -2475 6121
RABEPK 2040 5565
RABGAP1 1460 6385
RABGEF1 3005 3772
RAC1 4404 5541
RACGAP1 2182 4089
RALA -2065 2302
RALGAPA2 4285 -284
RALGAPB 143 3710
REPS1 41 6314
RGP1 2372 -1039
RHOBTB3 -32 1297
RHOQ 1613 -160
RIC1 2763 6857
RIN1 4557 -1288
RINL -646 6131
RINT1 -3883 3453
RPS27A -4269 2589
SAR1B 2728 3060
SBF1 -1870 3727
SCARB1 -248 4837
SCARB2 3951 3550
SCOC -3708 2228
SEC13 2199 6211
SEC16A 3331 4812
SEC22A -3026 2581
SEC22C -1101 5700
SEC23A 2702 1833
SEC23IP 177 1231
SEC24A 3575 4762
SEC24B 2183 -13
SEC24C 2332 -336
SEC24D 4409 1527
SEC31A 1591 2523
SFN 270 -1779
SH3GL1 3225 6040
SNAP23 3209 -471
SNAP29 3729 3148
SNAPIN 2719 1354
SNF8 2422 5287
SNX18 4555 -690
SNX2 2853 186
SPTAN1 -4215 -407
SPTBN1 -3763 3657
SPTBN5 914 2256
SRC -2136 -1476
STAM 398 6491
STAM2 2689 3301
STX10 3748 5277
STX16 833 1974
STX17 -3674 -218
STX18 2849 2718
STX4 2105 1609
STX5 3382 5926
STX6 3023 -252
STXBP3 2813 199
SURF4 3260 3679
SYNJ1 4109 2804
SYNJ2 -3998 -505
SYS1 -1056 4319
SYT11 2707 4051
SYTL1 -2430 -620
TBC1D1 3927 -1099
TBC1D10A -1489 5672
TBC1D10B 4078 6337
TBC1D10C -3594 6912
TBC1D13 2761 4704
TBC1D14 4432 30
TBC1D15 -550 5333
TBC1D17 -2016 6199
TBC1D2 4388 647
TBC1D20 747 1409
TBC1D24 1774 4060
TBC1D4 -4610 4593
TBC1D7 2603 5951
TFRC 1670 -131
TGFA 4325 4632
TGOLN2 4204 5919
TMED10 -974 3393
TMED2 2394 5946
TMED3 1979 5786
TMED7 2142 -959
TMED9 3384 1623
TMEM115 2240 -632
TMF1 1215 1642
TOR1A 3513 5481
TOR1B 3571 -606
TPD52 -3973 5618
TRAPPC1 3635 5233
TRAPPC10 117 6987
TRAPPC12 3557 7029
TRAPPC13 -297 7206
TRAPPC2L -945 1131
TRAPPC3 2092 -470
TRAPPC4 -960 1676
TRAPPC5 1256 29
TRAPPC6A -4241 -1706
TRAPPC6B 557 1818
TRAPPC8 2661 59
TRAPPC9 2575 -816
TRIP11 -951 5856
TSC1 -336 4696
TSC2 775 3951
TSG101 3030 -488
TXNDC5 -1496 -1873
UBA52 -1041 -69
UBAP1 4169 5038
UBB 509 5059
UBC 2477 3220
UBQLN1 1803 2747
ULK1 4375 1
USE1 -1903 654
USO1 1288 3424
USP6NL -427 5625
VAMP2 -3963 -1239
VAMP3 3838 619
VAMP4 -190 1517
VAMP8 592 868
VPS25 3656 -962
VPS28 73 6115
VPS36 -1430 1902
VPS37A 2775 3939
VPS37B 2793 -1611
VPS37C 4268 4035
VPS45 -153 3197
VPS4A 331 3112
VPS51 -3377 -1323
VPS52 119 5049
VPS53 2676 4288
VPS54 2045 -1404
VTA1 2056 3950
VTI1A 3327 3539
WASL 522 4645
YKT6 2709 3314
YWHAB 2512 2152
YWHAE 3796 1288
YWHAG 4225 1919
YWHAH 4276 -1276
YWHAQ -1174 3225
YWHAZ 2353 4294
ZW10 -339 -591



Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
metric value
setSize 70
pMANOVA 2.86e-22
p.adjustMANOVA 3.2e-20
s.dist 0.701
s.RNA -0.67
s.meth 0.205
p.RNA 3.06e-22
p.meth 0.00305




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
EEF1B2 -4122 3976
RPL37 -3012 5393

Click HERE to show all gene set members

All member genes
RNA meth
EEF1A1 -4143 2941
EEF1B2 -4122 3976
EEF1D -2206 5791
EEF1G -3784 111
EEF2 -2045 4196
FAU -1142 6877
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
UBA52 -1041 -69



Peptide chain elongation

Peptide chain elongation
metric value
setSize 67
pMANOVA 3.3e-21
p.adjustMANOVA 3.35e-19
s.dist 0.699
s.RNA -0.667
s.meth 0.208
p.RNA 3.57e-21
p.meth 0.00329




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393
RPL18 -3621 4479

Click HERE to show all gene set members

All member genes
RNA meth
EEF1A1 -4143 2941
EEF2 -2045 4196
FAU -1142 6877
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
UBA52 -1041 -69



Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
metric value
setSize 76
pMANOVA 1.03e-20
p.adjustMANOVA 9.59e-19
s.dist 0.648
s.RNA -0.622
s.meth 0.182
p.RNA 7.29e-21
p.meth 0.00622




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393
RPL18 -3621 4479

Click HERE to show all gene set members

All member genes
RNA meth
EIF3A 275 5855
EIF3B -3969 -704
EIF3E -3292 503
EIF3F -1695 1471
EIF3G -773 3038
EIF3H -1803 3706
EIF3I -227 696
EIF3J -1432 737
EIF3K -390 6636
EIF3L -2749 2568
EIF3M -1552 5836
FAU -1142 6877
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
UBA52 -1041 -69



Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication
metric value
setSize 110
pMANOVA 2.06e-20
p.adjustMANOVA 1.78e-18
s.dist 0.539
s.RNA -0.495
s.meth 0.215
p.RNA 3.54e-19
p.meth 0.000104




Top 20 genes
Gene RNA meth
NUP88 -4449 7084
RPS3A -4231 7068
RPL3 -4425 6753
NDC1 -4582 6482
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
NUP43 -3608 6346
RPL13A -4073 5523
IPO5 -4608 4875
RPS15A -3671 6112
RPL26 -3455 6409
NUP107 -3437 6301
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1807 1467
DNAJC3 3890 6472
FAU -1142 6877
GRSF1 27 4316
GTF2F1 2455 558
GTF2F2 2495 5307
HSP90AA1 -729 6210
IPO5 -4608 4875
NDC1 -4582 6482
NUP107 -3437 6301
NUP133 -2181 935
NUP153 -709 4344
NUP155 -3052 3043
NUP160 -3890 1293
NUP188 -3651 2922
NUP205 -3468 1670
NUP210 -1977 690
NUP214 3636 4369
NUP35 -4479 -557
NUP37 126 3398
NUP43 -3608 6346
NUP50 1354 6706
NUP54 -3105 831
NUP62 -1130 4609
NUP85 -1192 4518
NUP88 -4449 7084
NUP93 -2021 2006
NUP98 1358 -747
PARP1 -3863 3582
POLR2A 2412 4046
POLR2B -903 5563
POLR2C -520 6356
POLR2D -2238 -614
POLR2E 2119 3712
POLR2F 1375 509
POLR2G 1618 1604
POLR2H -2765 6299
POLR2I -1337 5657
POLR2K -1277 3853
POM121 -1045 4681
POM121C -663 2061
RAE1 1241 2634
RANBP2 -757 5165
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
SEC13 2199 6211
SEH1L -4328 3577
TPR -1675 4616
UBA52 -1041 -69



Metabolism of RNA

Metabolism of RNA
metric value
setSize 535
pMANOVA 6.33e-20
p.adjustMANOVA 5.06e-18
s.dist 0.247
s.RNA -0.228
s.meth 0.0964
p.RNA 7.31e-19
p.meth 0.000177




Top 20 genes
Gene RNA meth
NUP88 -4449 7084
GEMIN4 -4491 6849
TSR1 -4435 6839
RPS3A -4231 7068
RPL3 -4425 6753
NDC1 -4582 6482
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
NOP2 -3984 6403
QTRT1 -4259 5789
RPS12 -3875 6331
RPL32 -4069 6000
EXOSC2 -4475 5344
RPS5 -3931 6072
SNU13 -3338 7054
WDR43 -4245 5510
UPF3A -3318 6963
NUP43 -3608 6346

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1807 1467
ACTB 4359 5447
ADAR 1862 3087
ADARB1 -2161 -972
ADAT1 -530 5559
ADAT2 -3505 3497
ADAT3 1444 6334
AKT1 1891 1109
ALKBH8 -4523 5003
ALYREF 452 6737
ANP32A 4041 1765
AQR 418 -1471
BMS1 -4345 -1755
BUD31 2373 2740
BYSL -2249 6808
C1D 763 2322
C2orf49 -2260 2636
CASC3 3110 5106
CCAR1 -600 4000
CCNH 645 1260
CD2BP2 2398 -544
CD44 3690 4898
CDC40 2326 7125
CDC5L 2089 -742
CDK7 2068 4034
CDKAL1 -2241 4217
CHERP -1495 2907
CLNS1A -2361 -278
CLP1 2017 2378
CNOT1 1059 4959
CNOT10 -194 3018
CNOT11 246 3729
CNOT3 1882 3093
CNOT4 702 6001
CNOT6 2546 4653
CNOT6L -3217 6262
CNOT7 -3636 -58
CNOT8 1626 5798
CPSF1 -446 1083
CPSF2 2904 988
CPSF3 3136 5337
CPSF4 -1522 1770
CRNKL1 1079 5505
CSNK1D 2488 3046
CSNK1E -2944 3000
CSTF1 -2757 6209
CTNNBL1 2154 2615
CTU1 1570 4162
CTU2 -2353 7026
CWC15 -605 -1127
CWC22 -631 4010
CWC27 989 -818
DCAF13 -2402 862
DCP1A -1301 5069
DCP1B -3824 2554
DCP2 2690 5677
DCPS 707 5060
DDX1 -2550 2193
DDX20 -4175 3954
DDX21 510 3312
DDX23 948 2707
DDX42 231 1669
DDX46 971 2158
DDX47 -4298 -50
DDX49 1396 5582
DDX5 -3032 1804
DDX52 927 -204
DDX6 26 2014
DHX16 -238 3127
DHX37 -2117 4195
DHX9 -1320 5547
DIS3 -1331 -754
DNAJC8 325 861
DUS2 685 710
EBNA1BP2 -2609 6235
EDC3 1750 3531
EDC4 -1727 -1378
EFTUD2 3456 2652
EIF4A1 2418 881
EIF4A2 -4411 3601
EIF4A3 1061 4598
EIF4B -2753 5587
EIF4E 1167 6721
EIF4G1 4177 5766
ELAC2 -1929 275
ELAVL1 -781 1665
ENPP2 1838 3897
ERCC2 1784 1849
ERCC3 -87 1487
ERI1 2515 -139
ETF1 2922 151
EXOSC1 114 316
EXOSC10 -3062 802
EXOSC2 -4475 5344
EXOSC3 -127 3245
EXOSC4 3882 64
EXOSC5 -3672 790
EXOSC6 -2037 1534
EXOSC7 -3466 -158
EXOSC8 -4275 1364
FAM98B -2397 2205
FAU -1142 6877
FBL -4453 -43
FCF1 1012 6763
FIP1L1 -540 3099
FTSJ3 37 4236
FUS -2007 5262
FYTTD1 -1643 5127
GAR1 -2663 879
GCFC2 -4409 -1741
GEMIN2 -1175 -290
GEMIN4 -4491 6849
GEMIN5 -1659 1695
GEMIN6 -1310 -1086
GEMIN7 201 -388
GLE1 3438 1687
GNL3 -4514 1201
GSPT1 -173 -1155
GTF2F1 2455 558
GTF2F2 2495 5307
GTF2H3 -3181 5705
GTF2H4 -953 5240
GTF2H5 613 3417
GTPBP3 -3122 1640
HBS1L 578 598
HEATR1 -3399 5201
HNRNPA0 -3493 3059
HNRNPA2B1 979 2721
HNRNPC 1974 213
HNRNPD -704 -667
HNRNPF 839 5857
HNRNPH1 -3319 2373
HNRNPK 2115 3141
HNRNPL 1901 6119
HNRNPM 1748 2773
HNRNPR -3540 4903
HNRNPU 343 4167
HNRNPUL1 1739 2869
HSPA1A 3351 -920
HSPB1 -901 883
IGF2BP3 2501 -734
IMP3 -3090 5542
IMP4 -3470 3786
ISG20L2 1554 6438
ISY1 920 1885
KHSRP 458 1774
KRR1 -3409 -1952
LCMT2 -3476 6264
LSM1 1815 5934
LSM10 2140 1062
LSM11 -4170 -211
LSM2 199 5948
LSM3 -552 2560
LSM4 -3115 -239
LSM5 -3798 4274
LSM6 2318 2778
LSM7 -3452 689
LSM8 -3298 -1736
LTV1 -2899 2915
MAPK14 4478 2465
MAPKAPK2 3498 3265
METTL1 -4462 4406
METTL14 -1043 -834
MNAT1 -1772 1516
MPHOSPH10 -3582 5401
MPHOSPH6 -247 5535
MRM1 -4209 -159
MTERF4 -4550 3503
MTO1 -2876 396
NCBP1 -1093 5859
NCBP2 -4299 4777
NCL -3844 5054
NDC1 -4582 6482
NHP2 -2502 4827
NIP7 -2710 4219
NOB1 -3712 2003
NOC4L 535 -799
NOL11 -4544 2571
NOL12 970 -1551
NOL6 -3657 4557
NOL9 -3988 -1446
NOP10 4046 2081
NOP14 -4344 2209
NOP2 -3984 6403
NOP56 -4355 996
NOP58 -4534 1333
NSUN2 -489 2230
NSUN4 842 3316
NSUN6 -1292 2767
NUDT21 -3035 4271
NUP107 -3437 6301
NUP133 -2181 935
NUP153 -709 4344
NUP155 -3052 3043
NUP160 -3890 1293
NUP188 -3651 2922
NUP205 -3468 1670
NUP210 -1977 690
NUP214 3636 4369
NUP35 -4479 -557
NUP37 126 3398
NUP43 -3608 6346
NUP50 1354 6706
NUP54 -3105 831
NUP62 -1130 4609
NUP85 -1192 4518
NUP88 -4449 7084
NUP93 -2021 2006
NUP98 1358 -747
NXF1 1214 1236
NXT1 -3899 4713
PABPC1 50 3011
PABPN1 -414 3061
PAIP1 -1141 6167
PAN2 -1339 -743
PAN3 674 1365
PAPOLA 1641 4317
PARN -790 5479
PATL1 3713 -473
PCBP1 2458 865
PCBP2 2 3201
PDCD11 -2672 3455
PDCD7 -1482 3569
PELP1 -3840 2742
PES1 -1937 3288
PHAX -2471 5545
PLRG1 -2891 5211
PNO1 -2601 6496
PNRC2 -1202 5678
POLDIP3 3905 3182
POLR2A 2412 4046
POLR2B -903 5563
POLR2C -520 6356
POLR2D -2238 -614
POLR2E 2119 3712
POLR2F 1375 509
POLR2G 1618 1604
POLR2H -2765 6299
POLR2I -1337 5657
POLR2K -1277 3853
POM121 -1045 4681
POM121C -663 2061
POP1 -1854 3613
POP4 395 1072
POP5 -3578 5989
POP7 43 3070
PPIE -2923 6027
PPIH -3917 2129
PPIL1 -2818 -1626
PPIL3 -1749 375
PPIL4 -318 -164
PPIL6 1587 147
PPP2CA 2861 2598
PPP2R2A 726 -752
PPWD1 -3434 -1685
PRCC 1961 2255
PRKCA -1148 6894
PRKCD 4519 6360
PRMT5 159 2005
PRPF19 -3433 6017
PRPF3 -2194 1089
PRPF31 -1951 3855
PRPF38A 141 5306
PRPF40A 1034 5628
PRPF6 -1959 4285
PRPF8 -1874 516
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PTBP1 -1702 815
PUF60 -393 2049
PUS1 -3552 4830
PUS3 287 965
PUS7 -4154 5387
PWP2 -202 5076
QTRT1 -4259 5789
RAE1 1241 2634
RAN -3182 1483
RANBP2 -757 5165
RBM17 -3053 2268
RBM28 -2634 3412
RCL1 -2883 6343
RIOK1 -1965 6498
RIOK2 -2842 1638
RIOK3 2889 3472
RNGTT 1072 14
RNMT -3141 6871
RNPC3 -1876 3737
RNPS1 -3275 537
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPP14 118 2236
RPP21 -2049 2599
RPP25 -3481 5745
RPP30 -3480 668
RPP38 -3570 4780
RPP40 -4564 570
RPPH1 4228 5012
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
RRP1 -978 5200
RRP7A -1380 1582
RRP9 -3749 653
RTCB 713 -1473
SART1 2384 5777
SEC13 2199 6211
SEH1L -4328 3577
SENP3 -372 5394
SET -2527 -1667
SF1 -737 2873
SF3A1 -84 6187
SF3A2 -2098 7185
SF3A3 -3130 4521
SF3B2 1418 2483
SF3B3 -3383 423
SF3B4 1349 1093
SF3B5 -96 2879
SKIV2L 722 6259
SLBP 84 428
SLU7 1076 1094
SMG1 -799 4789
SMG5 1593 5173
SMG6 -484 6207
SMG7 3516 2361
SMG8 1315 1691
SMNDC1 1616 3512
SNRNP200 -2489 1391
SNRNP25 -483 2891
SNRNP27 1361 1452
SNRNP35 1918 -1468
SNRNP40 -3453 6269
SNRNP48 -1787 -1045
SNRNP70 -3616 2532
SNRPA -27 1269
SNRPA1 -3020 1539
SNRPB -1019 4948
SNRPB2 -100 1876
SNRPC -909 3152
SNRPD1 -1878 4845
SNRPD2 -2966 -551
SNRPD3 -2366 -377
SNRPE -2958 3730
SNRPG 445 3411
SNRPN -3748 -1424
SNU13 -3338 7054
SNUPN 1170 2739
SNW1 1711 2517
SRRM1 -477 3813
SRRM2 -296 -214
SRRT -2680 1308
SRSF10 -4052 2085
SRSF11 -3976 -51
SRSF2 -3314 212
SRSF3 -1955 -1225
SRSF4 2720 6867
SRSF7 -3519 618
SRSF9 3299 745
SUPT5H -1710 2020
SYF2 1436 4212
SYMPK -195 2886
TBL3 -235 5418
TEX10 -3806 1204
TFB1M -2921 1831
TFIP11 1042 936
THADA -2866 4244
THG1L -2457 2917
THOC1 -3593 6023
THOC5 4156 3364
THOC7 1231 5594
THUMPD1 -4426 -871
TNFSF13 4042 -1364
TNKS1BP1 -3529 3401
TNPO1 708 4635
TP53RK -3679 2847
TPR -1675 4616
TPRKB -3210 3473
TRDMT1 -519 -401
TRIT1 -1914 6755
TRMT1 -3114 -744
TRMT10A 2348 1313
TRMT11 -4370 2032
TRMT112 -966 1929
TRMT12 -807 -1653
TRMT44 -2698 -1516
TRMT6 3319 3940
TRMT61A -3119 3423
TRMT61B -3983 5388
TRMU -2518 6387
TRNT1 -2354 4675
TSEN15 -3334 502
TSEN2 -3696 3306
TSEN34 3376 1820
TSEN54 -3374 591
TSR1 -4435 6839
TSR3 1137 6370
TTC37 -3061 334
TXNL4A 2165 2176
TYW1 -4060 2393
TYW3 -4145 985
TYW5 548 3607
U2AF1 2605 1030
U2AF1L4 -517 5616
U2AF2 -844 6132
U2SURP -1575 6592
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
UPF1 2857 5958
UPF2 652 3840
UPF3A -3318 6963
URM1 -458 3783
USP39 1461 5626
UTP15 -4147 5063
UTP18 1330 3357
UTP20 -3435 5085
UTP3 -1599 3926
UTP6 -3440 3932
WBP11 -3463 986
WBP4 1999 1882
WDR12 475 6794
WDR18 -1194 -1078
WDR3 -3009 -1387
WDR33 -1054 3468
WDR36 -2277 6601
WDR43 -4245 5510
WDR61 -718 1522
WDR75 -4506 4614
WDR77 -4200 2831
WTAP 1081 3489
XAB2 -175 1760
XPO1 -925 6847
XPOT -1979 2981
XRN1 -865 -1961
XRN2 4157 -29
YBX1 1836 6425
YWHAB 2512 2152
YWHAZ 2353 4294
ZBTB8OS 2016 266
ZCRB1 392 438
ZFP36 1389 5100
ZFP36L1 1646 5471
ZMAT5 3397 6884



Selenocysteine synthesis

Selenocysteine synthesis
metric value
setSize 68
pMANOVA 7.85e-20
p.adjustMANOVA 5.86e-18
s.dist 0.669
s.RNA -0.643
s.meth 0.184
p.RNA 4.6e-20
p.meth 0.00884




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393
RPL18 -3621 4479

Click HERE to show all gene set members

All member genes
RNA meth
EEFSEC -2209 1972
FAU -1142 6877
PSTK -2595 -729
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
SEPHS2 3053 1949
UBA52 -1041 -69



Viral mRNA Translation

Viral mRNA Translation
metric value
setSize 67
pMANOVA 1.49e-19
p.adjustMANOVA 1.04e-17
s.dist 0.671
s.RNA -0.634
s.meth 0.22
p.RNA 2.73e-19
p.meth 0.0019




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393
RPL18 -3621 4479

Click HERE to show all gene set members

All member genes
RNA meth
DNAJC3 3890 6472
FAU -1142 6877
GRSF1 27 4316
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
UBA52 -1041 -69



Eukaryotic Translation Termination

Eukaryotic Translation Termination
metric value
setSize 70
pMANOVA 7.1e-19
p.adjustMANOVA 4.67e-17
s.dist 0.642
s.RNA -0.622
s.meth 0.158
p.RNA 2.37e-19
p.meth 0.0225




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393
RPL18 -3621 4479

Click HERE to show all gene set members

All member genes
RNA meth
APEH 1920 832
ETF1 2922 151
FAU -1142 6877
GSPT1 -173 -1155
N6AMT1 -4391 62
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
TRMT112 -966 1929
UBA52 -1041 -69



GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
metric value
setSize 86
pMANOVA 2.89e-18
p.adjustMANOVA 1.8e-16
s.dist 0.573
s.RNA -0.539
s.meth 0.195
p.RNA 6.13e-18
p.meth 0.00178




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393
RPL18 -3621 4479

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 71 4745
EIF2S2 1496 6254
EIF3A 275 5855
EIF3B -3969 -704
EIF3E -3292 503
EIF3F -1695 1471
EIF3G -773 3038
EIF3H -1803 3706
EIF3I -227 696
EIF3J -1432 737
EIF3K -390 6636
EIF3L -2749 2568
EIF3M -1552 5836
EIF4A1 2418 881
EIF4A2 -4411 3601
EIF4B -2753 5587
EIF4E 1167 6721
EIF4G1 4177 5766
EIF4H 3100 -1988
EIF5 977 4313
EIF5B -1654 4183
FAU -1142 6877
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
UBA52 -1041 -69



L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
metric value
setSize 85
pMANOVA 3.11e-18
p.adjustMANOVA 1.83e-16
s.dist 0.576
s.RNA -0.543
s.meth 0.19
p.RNA 5.15e-18
p.meth 0.00247




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393
RPL18 -3621 4479

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 71 4745
EIF2S2 1496 6254
EIF3A 275 5855
EIF3B -3969 -704
EIF3E -3292 503
EIF3F -1695 1471
EIF3G -773 3038
EIF3H -1803 3706
EIF3I -227 696
EIF3J -1432 737
EIF3K -390 6636
EIF3L -2749 2568
EIF3M -1552 5836
EIF4A1 2418 881
EIF4A2 -4411 3601
EIF4B -2753 5587
EIF4E 1167 6721
EIF4G1 4177 5766
EIF4H 3100 -1988
FAU -1142 6877
PABPC1 50 3011
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
UBA52 -1041 -69



Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
metric value
setSize 72
pMANOVA 3.41e-18
p.adjustMANOVA 1.91e-16
s.dist 0.624
s.RNA -0.589
s.meth 0.206
p.RNA 5.47e-18
p.meth 0.00259




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
NCBP2 -4299 4777
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393

Click HERE to show all gene set members

All member genes
RNA meth
EIF4G1 4177 5766
ETF1 2922 151
FAU -1142 6877
GSPT1 -173 -1155
NCBP1 -1093 5859
NCBP2 -4299 4777
PABPC1 50 3011
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
UBA52 -1041 -69
UPF1 2857 5958



Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
metric value
setSize 93
pMANOVA 3.44e-17
p.adjustMANOVA 1.75e-15
s.dist 0.535
s.RNA -0.499
s.meth 0.193
p.RNA 1e-16
p.meth 0.00133




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393
RPL18 -3621 4479

Click HERE to show all gene set members

All member genes
RNA meth
EIF2B1 -748 6669
EIF2B2 2542 -173
EIF2B3 -1990 1141
EIF2B4 1188 3641
EIF2B5 -2565 5042
EIF2S1 71 4745
EIF2S2 1496 6254
EIF3A 275 5855
EIF3B -3969 -704
EIF3E -3292 503
EIF3F -1695 1471
EIF3G -773 3038
EIF3H -1803 3706
EIF3I -227 696
EIF3J -1432 737
EIF3K -390 6636
EIF3L -2749 2568
EIF3M -1552 5836
EIF4A1 2418 881
EIF4A2 -4411 3601
EIF4B -2753 5587
EIF4E 1167 6721
EIF4EBP1 1533 4398
EIF4G1 4177 5766
EIF4H 3100 -1988
EIF5 977 4313
EIF5B -1654 4183
FAU -1142 6877
PABPC1 50 3011
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
UBA52 -1041 -69



Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
metric value
setSize 93
pMANOVA 3.44e-17
p.adjustMANOVA 1.75e-15
s.dist 0.535
s.RNA -0.499
s.meth 0.193
p.RNA 1e-16
p.meth 0.00133




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393
RPL18 -3621 4479

Click HERE to show all gene set members

All member genes
RNA meth
EIF2B1 -748 6669
EIF2B2 2542 -173
EIF2B3 -1990 1141
EIF2B4 1188 3641
EIF2B5 -2565 5042
EIF2S1 71 4745
EIF2S2 1496 6254
EIF3A 275 5855
EIF3B -3969 -704
EIF3E -3292 503
EIF3F -1695 1471
EIF3G -773 3038
EIF3H -1803 3706
EIF3I -227 696
EIF3J -1432 737
EIF3K -390 6636
EIF3L -2749 2568
EIF3M -1552 5836
EIF4A1 2418 881
EIF4A2 -4411 3601
EIF4B -2753 5587
EIF4E 1167 6721
EIF4EBP1 1533 4398
EIF4G1 4177 5766
EIF4H 3100 -1988
EIF5 977 4313
EIF5B -1654 4183
FAU -1142 6877
PABPC1 50 3011
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
UBA52 -1041 -69



Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
metric value
setSize 76
pMANOVA 4.25e-17
p.adjustMANOVA 2.02e-15
s.dist 0.587
s.RNA -0.562
s.meth 0.167
p.RNA 2.42e-17
p.meth 0.012




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393
RPL18 -3621 4479

Click HERE to show all gene set members

All member genes
RNA meth
ASNS -3231 -387
ATF3 -1158 2814
ATF4 483 765
CEBPB 4463 337
CEBPG 1720 1321
DDIT3 1573 5192
EIF2AK4 283 2103
EIF2S1 71 4745
EIF2S2 1496 6254
FAU -1142 6877
GCN1 -2750 -1761
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
TRIB3 207 3767
UBA52 -1041 -69



Influenza Infection

Influenza Infection
metric value
setSize 128
pMANOVA 4.34e-17
p.adjustMANOVA 2.02e-15
s.dist 0.458
s.RNA -0.408
s.meth 0.207
p.RNA 1.73e-15
p.meth 5.65e-05




Top 20 genes
Gene RNA meth
NUP88 -4449 7084
RPS3A -4231 7068
RPL3 -4425 6753
NDC1 -4582 6482
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
NUP43 -3608 6346
RPL13A -4073 5523
IPO5 -4608 4875
RPS15A -3671 6112
RPL26 -3455 6409
NUP107 -3437 6301
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1807 1467
CALR 2667 5714
CANX 1895 3479
CLTA 3106 -546
CLTC 4203 7259
CPSF4 -1522 1770
DNAJC3 3890 6472
EIF2AK2 1466 683
FAU -1142 6877
GRSF1 27 4316
GTF2F1 2455 558
GTF2F2 2495 5307
HSP90AA1 -729 6210
HSPA1A 3351 -920
IPO5 -4608 4875
ISG15 -2022 6541
KPNA1 -443 4423
KPNA2 66 4421
KPNA3 -12 4400
KPNA4 2166 5000
KPNA5 -4039 1847
KPNB1 1964 1140
NDC1 -4582 6482
NUP107 -3437 6301
NUP133 -2181 935
NUP153 -709 4344
NUP155 -3052 3043
NUP160 -3890 1293
NUP188 -3651 2922
NUP205 -3468 1670
NUP210 -1977 690
NUP214 3636 4369
NUP35 -4479 -557
NUP37 126 3398
NUP43 -3608 6346
NUP50 1354 6706
NUP54 -3105 831
NUP62 -1130 4609
NUP85 -1192 4518
NUP88 -4449 7084
NUP93 -2021 2006
NUP98 1358 -747
PABPN1 -414 3061
PARP1 -3863 3582
POLR2A 2412 4046
POLR2B -903 5563
POLR2C -520 6356
POLR2D -2238 -614
POLR2E 2119 3712
POLR2F 1375 509
POLR2G 1618 1604
POLR2H -2765 6299
POLR2I -1337 5657
POLR2K -1277 3853
POM121 -1045 4681
POM121C -663 2061
RAE1 1241 2634
RAN -3182 1483
RANBP2 -757 5165
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
SEC13 2199 6211
SEH1L -4328 3577
TGFB1 2241 3769
TPR -1675 4616
UBA52 -1041 -69
XPO1 -925 6847



Selenoamino acid metabolism

Selenoamino acid metabolism
metric value
setSize 76
pMANOVA 7.45e-17
p.adjustMANOVA 3.33e-15
s.dist 0.582
s.RNA -0.558
s.meth 0.166
p.RNA 4.19e-17
p.meth 0.0125




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393
RPL18 -3621 4479

Click HERE to show all gene set members

All member genes
RNA meth
AHCY -854 5996
AIMP2 -308 5643
CTH -1245 3809
EEF1E1 -518 -948
EEFSEC -2209 1972
FAU -1142 6877
GSR 4556 4125
PAPSS1 4245 2272
PSTK -2595 -729
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
SCLY -3396 2139
SEPHS2 3053 1949
TXNRD1 3917 -1402
UBA52 -1041 -69



Translation

Translation
metric value
setSize 234
pMANOVA 1.06e-16
p.adjustMANOVA 4.57e-15
s.dist 0.33
s.RNA -0.326
s.meth 0.0472
p.RNA 1.18e-17
p.meth 0.217




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
SRPRB -3229 6605
RPS29 -3767 5602
MRPS9 -3544 5774
RPL23A -4486 4560
MRPL39 -3108 6177
MRPL48 -3230 5773
RPS3 -3960 4599

Click HERE to show all gene set members

All member genes
RNA meth
AARS2 -3893 952
AIMP2 -308 5643
APEH 1920 832
AURKAIP1 1615 4899
CARS2 2699 3857
CHCHD1 1678 5961
DAP3 -2232 3981
DARS2 1160 -1324
EARS2 -3944 -610
EEF1A1 -4143 2941
EEF1B2 -4122 3976
EEF1D -2206 5791
EEF1E1 -518 -948
EEF1G -3784 111
EEF2 -2045 4196
EIF2B1 -748 6669
EIF2B2 2542 -173
EIF2B3 -1990 1141
EIF2B4 1188 3641
EIF2B5 -2565 5042
EIF2S1 71 4745
EIF2S2 1496 6254
EIF3A 275 5855
EIF3B -3969 -704
EIF3E -3292 503
EIF3F -1695 1471
EIF3G -773 3038
EIF3H -1803 3706
EIF3I -227 696
EIF3J -1432 737
EIF3K -390 6636
EIF3L -2749 2568
EIF3M -1552 5836
EIF4A1 2418 881
EIF4A2 -4411 3601
EIF4B -2753 5587
EIF4E 1167 6721
EIF4EBP1 1533 4398
EIF4G1 4177 5766
EIF4H 3100 -1988
EIF5 977 4313
EIF5B -1654 4183
ERAL1 -452 5758
ETF1 2922 151
FARS2 -3720 2999
FARSA 192 3072
FARSB -3421 2500
FAU -1142 6877
GADD45GIP1 -462 351
GFM1 -3549 1128
GFM2 683 4209
GSPT1 -173 -1155
HARS2 -156 2446
IARS2 786 3733
LARS2 -2627 -1562
MARS2 -3879 951
MRPL1 -2414 452
MRPL10 1535 -1245
MRPL11 -1508 3156
MRPL12 -1123 5433
MRPL13 703 1510
MRPL14 -2417 -354
MRPL15 -561 5966
MRPL16 -161 350
MRPL18 -898 4037
MRPL19 -1391 1189
MRPL2 -1057 -1977
MRPL20 -634 -1814
MRPL21 -289 1490
MRPL22 477 -877
MRPL23 2163 -547
MRPL24 -3317 1499
MRPL27 -1250 5382
MRPL30 -79 5642
MRPL32 -3456 2250
MRPL33 1324 110
MRPL34 -1666 4947
MRPL35 -2484 2146
MRPL36 826 6690
MRPL37 1071 4357
MRPL38 -3165 -344
MRPL39 -3108 6177
MRPL4 -840 6863
MRPL41 -1415 1121
MRPL42 -3137 1175
MRPL43 -1806 1544
MRPL44 1385 -911
MRPL45 -2108 5889
MRPL46 -3646 2383
MRPL47 336 4371
MRPL48 -3230 5773
MRPL49 -2257 4584
MRPL50 -4233 2815
MRPL51 1211 -1091
MRPL52 757 1666
MRPL53 2278 940
MRPL54 -1829 3949
MRPL55 -1611 1428
MRPL57 -1834 -1250
MRPL9 -2849 -787
MRPS10 148 -184
MRPS11 959 2490
MRPS12 -1504 -442
MRPS14 -3245 4424
MRPS15 565 4305
MRPS16 602 730
MRPS17 -2305 1178
MRPS18A 262 255
MRPS18B -3252 -1837
MRPS18C -370 3763
MRPS2 -2843 -101
MRPS21 -2405 1336
MRPS22 121 2961
MRPS23 -767 -991
MRPS24 517 3928
MRPS25 -4260 175
MRPS26 -2135 6275
MRPS27 -3964 -258
MRPS28 -1386 3988
MRPS30 -3603 4772
MRPS31 -1298 407
MRPS33 -3997 1674
MRPS34 -627 5239
MRPS35 228 1580
MRPS36 921 2055
MRPS5 1293 406
MRPS6 -4325 3007
MRPS7 -2499 1187
MRPS9 -3544 5774
MTFMT 1727 2857
MTIF2 -293 886
MTIF3 245 2044
MTRF1L 2342 2350
N6AMT1 -4391 62
NARS2 -4461 3408
OXA1L 926 4016
PABPC1 50 3011
PARS2 -545 198
PPA1 -1830 4284
PPA2 321 1044
PTCD3 -3109 1340
RARS2 -170 4009
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPN1 3105 6053
RPN2 3531 5501
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
SARS2 -3184 4936
SEC11A 3032 5768
SEC11C -2653 4501
SEC61A1 2782 421
SEC61A2 -2339 301
SEC61B 1866 6424
SEC61G 24 1928
SPCS2 258 6694
SPCS3 836 1497
SRP14 2428 5764
SRP19 893 5846
SRP54 2915 4032
SRP68 484 4340
SRP72 -761 307
SRPRB -3229 6605
SSR1 1121 3856
SSR2 -564 -133
SSR3 1611 -75
TARS2 233 2530
TRAM1 -1604 906
TRMT112 -966 1929
TSFM -1844 3207
TUFM 721 4618
UBA52 -1041 -69
VARS2 -1981 579
WARS2 -3192 3747
YARS2 -2186 2463



Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
metric value
setSize 86
pMANOVA 1.51e-15
p.adjustMANOVA 6.03e-14
s.dist 0.529
s.RNA -0.483
s.meth 0.215
p.RNA 9.97e-15
p.meth 0.00058




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
UPF3A -3318 6963
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
NCBP2 -4299 4777
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189

Click HERE to show all gene set members

All member genes
RNA meth
CASC3 3110 5106
DCP1A -1301 5069
EIF4A3 1061 4598
EIF4G1 4177 5766
ETF1 2922 151
FAU -1142 6877
GSPT1 -173 -1155
NCBP1 -1093 5859
NCBP2 -4299 4777
PABPC1 50 3011
PNRC2 -1202 5678
PPP2CA 2861 2598
PPP2R2A 726 -752
RNPS1 -3275 537
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
SMG1 -799 4789
SMG5 1593 5173
SMG6 -484 6207
SMG7 3516 2361
SMG8 1315 1691
UBA52 -1041 -69
UPF1 2857 5958
UPF2 652 3840
UPF3A -3318 6963



Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
metric value
setSize 86
pMANOVA 1.51e-15
p.adjustMANOVA 6.03e-14
s.dist 0.529
s.RNA -0.483
s.meth 0.215
p.RNA 9.97e-15
p.meth 0.00058




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
UPF3A -3318 6963
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
NCBP2 -4299 4777
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189

Click HERE to show all gene set members

All member genes
RNA meth
CASC3 3110 5106
DCP1A -1301 5069
EIF4A3 1061 4598
EIF4G1 4177 5766
ETF1 2922 151
FAU -1142 6877
GSPT1 -173 -1155
NCBP1 -1093 5859
NCBP2 -4299 4777
PABPC1 50 3011
PNRC2 -1202 5678
PPP2CA 2861 2598
PPP2R2A 726 -752
RNPS1 -3275 537
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
SMG1 -799 4789
SMG5 1593 5173
SMG6 -484 6207
SMG7 3516 2361
SMG8 1315 1691
UBA52 -1041 -69
UPF1 2857 5958
UPF2 652 3840
UPF3A -3318 6963



SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
metric value
setSize 85
pMANOVA 7.97e-15
p.adjustMANOVA 3.08e-13
s.dist 0.519
s.RNA -0.477
s.meth 0.205
p.RNA 3.29e-14
p.meth 0.00113




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
SRPRB -3229 6605
RPS29 -3767 5602
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189
RPL37 -3012 5393

Click HERE to show all gene set members

All member genes
RNA meth
FAU -1142 6877
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPN1 3105 6053
RPN2 3531 5501
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
SEC11A 3032 5768
SEC11C -2653 4501
SEC61A1 2782 421
SEC61A2 -2339 301
SEC61B 1866 6424
SEC61G 24 1928
SPCS2 258 6694
SPCS3 836 1497
SRP14 2428 5764
SRP19 893 5846
SRP54 2915 4032
SRP68 484 4340
SRP72 -761 307
SRPRB -3229 6605
SSR1 1121 3856
SSR2 -564 -133
SSR3 1611 -75
TRAM1 -1604 906
UBA52 -1041 -69



Signaling by Receptor Tyrosine Kinases

Signaling by Receptor Tyrosine Kinases
metric value
setSize 284
pMANOVA 8.99e-15
p.adjustMANOVA 3.35e-13
s.dist 0.276
s.RNA 0.274
s.meth 0.0329
p.RNA 2.9e-15
p.meth 0.344




Top 20 genes
Gene RNA meth
FURIN 4429 7181
ATP6V0D1 4488 6936
CLTC 4203 7259
PTPRJ 4193 7170
PRKCD 4519 6360
MAPK1 4560 6099
RALB 4066 6833
CRK 4199 6598
GRB2 4420 6241
SHB 4005 6644
PTPN6 4000 6542
ATP6V1C1 3831 6759
ELMO2 4026 6110
APH1B 3617 6785
RAC1 4404 5541
IRS2 3955 6152
SPRED2 4200 5462
VAV1 3798 5834
EPN1 4367 5034
PSEN1 4223 4955

Click HERE to show all gene set members

All member genes
RNA meth
AAMP -2190 7121
ABI1 3644 3253
ABI2 -3635 -206
ADAM10 4095 2760
ADAM17 4436 4155
ADAP1 3829 -1541
ADORA2A 616 7186
AHCYL1 2934 2692
AKT1 1891 1109
AKT2 781 5431
AP2A1 4623 -316
AP2M1 3567 3723
AP2S1 3281 6039
APH1A 1304 -119
APH1B 3617 6785
ARF6 1051 3741
ARHGEF7 -611 330
ATF1 1229 2989
ATP6V0A1 4546 -1571
ATP6V0A2 -2629 6653
ATP6V0B 3723 5503
ATP6V0C 4483 2933
ATP6V0D1 4488 6936
ATP6V0E1 3450 1836
ATP6V0E2 -4253 -1327
ATP6V1A 3956 -1497
ATP6V1B2 3836 -1555
ATP6V1C1 3831 6759
ATP6V1D 4067 1096
ATP6V1E1 3280 4776
ATP6V1F 1531 -699
ATP6V1G2 -4149 3740
ATP6V1H 3287 2559
BAIAP2 -1012 2757
BAX 1666 1161
BRAF 1030 -1526
BRK1 1195 3071
CALM1 263 4502
CAV1 249 4592
CBL 3732 1012
CDC42 3449 856
CDK5 4361 3491
CDK5R1 202 7124
CHD4 -63 640
CHEK1 -1742 51
CLTA 3106 -546
CLTC 4203 7259
COL9A2 194 4444
CREB1 -1458 1422
CRK 4199 6598
CRKL 1455 5167
CSK 3371 4890
CTNNB1 3473 5070
CTNND1 -33 -1709
CUL5 -968 344
CYBA 4037 2019
CYFIP1 4176 256
CYFIP2 -1121 6159
DIAPH1 2862 2371
DLG4 3550 2607
DNAL4 -395 2609
DNM1 2517 1607
DNM2 3828 3063
DOCK7 -1420 2327
DUSP3 2975 2260
DUSP4 -384 2494
DUSP6 -702 -1943
DUSP7 -732 722
EGR1 -1170 1893
EGR2 -2296 4748
ELMO1 1982 939
ELMO2 4026 6110
EP300 3478 4901
EPN1 4367 5034
EPS15 2111 -516
EPS15L1 2760 2728
ERBB2 -2008 4160
ESRP2 85 -276
FER -601 2567
FES 4502 -1638
FGF9 -3638 997
FGFBP3 -1793 207
FGFRL1 -675 5867
FLT3LG -4600 6677
FOS 692 5647
FOSB -841 1975
FOSL1 3134 6224
FRS2 -959 -882
FRS3 2713 6525
FURIN 4429 7181
FYN -1686 2793
GAB2 4007 2390
GALNT3 3300 -712
GGA3 2518 671
GRAP2 -265 3631
GRB10 4652 3328
GRB2 4420 6241
GTF2F1 2455 558
GTF2F2 2495 5307
HBEGF 646 -1007
HGS 2818 4351
HNRNPF 839 5857
HNRNPH1 -3319 2373
HNRNPM 1748 2773
HRAS -2340 -823
HSP90AA1 -729 6210
HSPB1 -901 883
ID1 2910 5399
ID2 3560 1192
ID3 -3199 -55
IGF1R 1912 -1422
INSR 3857 3558
IRS1 -2666 4308
IRS2 3955 6152
ITCH 2362 4854
ITGA2 -1026 -260
ITGAV 2675 -370
ITPR1 -1851 1789
ITPR2 2474 -44
ITPR3 -2973 2189
JAK2 1159 6489
JUNB 2048 5018
JUND -708 4243
KIDINS220 3496 3650
KRAS 2245 3139
LAMA2 -1632 6004
LAMB2 -214 1884
LCK -4408 7246
LRIG1 -4545 -692
LYL1 3822 -1349
MAP2K1 4239 1533
MAP2K2 2556 6410
MAP2K5 804 3448
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
MAPK7 3610 -244
MAPKAP1 1834 5908
MAPKAPK2 3498 3265
MAPKAPK3 4597 2896
MEF2A 3826 3013
MEF2D 1716 177
MEMO1 3289 1334
MKNK1 4108 1392
MLST8 -394 2258
MST1 881 1923
MST1R -1259 -1885
MTOR -141 3900
MXD4 -1541 6707
NAB1 469 5391
NAB2 -2294 3891
NCBP1 -1093 5859
NCBP2 -4299 4777
NCF4 4148 -1941
NCK1 -3877 1018
NCK2 -480 1378
NCKAP1L 4619 -320
NCOR1 3183 -530
NCSTN 4654 1224
NEDD4 3884 -1106
NELFB 829 -649
NOS3 -3550 4048
NTRK1 -1971 7049
PAG1 2231 6279
PAK1 3814 2452
PAK2 3574 283
PCSK5 2248 -869
PDE3B -4123 3507
PDPK1 3218 346
PGF 1058 -1150
PIK3CA 946 1470
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R3 995 3645
PIK3R4 -1326 2170
PLCG1 -4367 958
POLR2A 2412 4046
POLR2B -903 5563
POLR2C -520 6356
POLR2D -2238 -614
POLR2E 2119 3712
POLR2F 1375 509
POLR2G 1618 1604
POLR2H -2765 6299
POLR2I -1337 5657
POLR2K -1277 3853
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5D 2123 3470
PRKACA 4634 890
PRKACB -4510 1712
PRKCA -1148 6894
PRKCB 3491 4964
PRKCD 4519 6360
PRKCE 2768 -1185
PRKCZ -2913 -1376
PRR5 -2935 -347
PSEN1 4223 4955
PSEN2 -2281 -162
PSENEN 2445 4980
PTBP1 -1702 815
PTK2 -81 -475
PTK2B 4451 4529
PTPN1 4210 699
PTPN11 2499 5062
PTPN12 3373 -982
PTPN18 4484 3436
PTPN2 3642 181
PTPN6 4000 6542
PTPRJ 4193 7170
PTPRU 2459 -1728
PXN 3736 -814
RAB4A 480 559
RAB4B 3084 4688
RAC1 4404 5541
RALA -2065 2302
RALB 4066 6833
RALGDS -3164 6406
RANBP10 1007 5496
RANBP9 2528 884
RAP1A 3123 6569
RAP1B 3135 5968
RAPGEF1 1580 6445
RASA1 1788 3434
REST 1134 1286
RHOA 3965 4033
RICTOR -2640 2833
RIT1 4354 2694
RNF41 4019 4402
ROCK1 3502 2732
RPS27A -4269 2589
RPS6KA1 4497 -1859
RPS6KA2 1476 2117
RPS6KA5 -4234 1991
SGK1 -2329 -1194
SH2B3 2478 3851
SH2D2A -2019 6509
SH3GL1 3225 6040
SHB 4005 6644
SHC1 3684 3205
SOCS1 1954 4130
SOS1 -1564 -1986
SPRED1 1438 6065
SPRED2 4200 5462
SPRY1 -719 2310
SPRY2 1217 1690
SRC -2136 -1476
SRF 3298 2816
STAM 398 6491
STAM2 2689 3301
STAT1 -4254 4970
STAT3 3772 4995
STAT5A 2951 -1545
STAT5B 2832 1495
STAT6 3358 3854
STMN1 -3082 3009
STUB1 -602 2320
TAB2 605 6401
TCF12 501 -542
TCIRG1 4397 1353
TEC 3744 170
TGFA 4325 4632
THBS3 2314 -662
THEM4 -4605 809
TIA1 -2132 2854
TIAL1 -1748 5521
TLR9 -1039 7204
TRIB3 207 3767
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
USP8 2773 4109
VAV1 3798 5834
VAV2 803 4134
VAV3 3247 -685
VEGFA 2025 87
VRK3 2298 2903
WASF1 4564 -830
WASF2 4427 -134
WWOX -3828 4712
WWP1 -4551 479
YES1 -1029 5198
YWHAB 2512 2152



Hemostasis

Hemostasis
metric value
setSize 303
pMANOVA 1.38e-13
p.adjustMANOVA 4.97e-12
s.dist 0.259
s.RNA 0.259
s.meth -0.0123
p.RNA 1.43e-14
p.meth 0.715




Top 20 genes
Gene RNA meth
P2RX1 4648 -1949
GNA15 4439 -1924
NFE2 4593 -1804
SLC16A3 4572 -1654
TOR4A 4489 -1620
GNAQ 3913 -1832
ATP2A2 3880 -1550
EHD2 3098 -1841
PDE1B 4090 -1314
SELPLG 3316 -1614
KIF3C 3608 -1430
FGR 4616 -1075
APLP2 4509 -964
SLC7A5 2267 -1904
TLN1 4172 -983
MICAL1 4312 -904
SERPINE2 2253 -1730
AKAP10 3408 -1112
PLAUR 4124 -861
MFN2 3356 -1030

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -376 567
AAMP -2190 7121
ABCC4 1768 2355
ABHD12 -1193 5950
ABHD6 3026 2533
ABL1 1975 2469
ACTN1 3577 7240
ACTN4 4164 1596
AK3 -448 485
AKAP1 -4548 5977
AKAP10 3408 -1112
AKT1 1891 1109
ALDOA 4426 5367
ANXA5 3811 2872
APBB1IP 4238 3821
APLP2 4509 -964
APP 2952 6623
ARRB1 1885 -1278
ARRB2 4237 2913
ATP1B1 -1076 6453
ATP1B3 3149 4129
ATP2A1 -104 5724
ATP2A2 3880 -1550
ATP2A3 577 1877
ATP2B4 2564 4069
BRPF3 -744 3308
BSG 4125 205
C1QBP -3634 5787
CABLES2 -746 -697
CALM1 263 4502
CALU 3586 1962
CAP1 3919 2034
CAPZA1 3861 999
CAPZA2 3520 4667
CAPZB 3889 -308
CAV1 249 4592
CD2 -4096 7277
CD244 -696 3968
CD44 3690 4898
CD47 -4015 6603
CD48 317 6883
CD58 3673 -611
CD63 4635 5434
CD74 -3538 -648
CD84 2333 304
CDC37L1 -3085 519
CDC42 3449 856
CDK2 -1525 2965
CDK5 4361 3491
CEACAM1 2004 5459
CENPE 2579 -74
CFL1 3970 1646
CHID1 494 1830
CRK 4199 6598
CSK 3371 4890
CYB5R1 4477 5881
DAGLB 4077 -302
DGKA -4082 7033
DGKD 1369 4806
DGKE -3850 6507
DGKG 3273 4393
DGKH -1084 4127
DGKQ -641 3114
DGKZ -1261 -1315
DOCK10 -4047 -1158
DOCK4 4390 4094
DOCK7 -1420 2327
DOCK8 3407 900
DOCK9 -4519 5506
DOK2 1850 1156
EHD1 2634 904
EHD2 3098 -1841
EHD3 911 -335
ENDOD1 715 -639
F11R 2121 -1146
F12 4633 1484
FAM3C -4121 32
FERMT3 4479 5112
FGR 4616 -1075
FYN -1686 2793
GATA3 -4581 6274
GLG1 1906 1825
GNA12 -49 4303
GNA13 2128 3330
GNA15 4439 -1924
GNAI2 4151 3218
GNAI3 3381 2359
GNAQ 3913 -1832
GNAS 2180 -60
GNB1 4261 2799
GNB2 4032 1879
GNB4 3205 1335
GNB5 -1662 6256
GNG2 1513 6500
GNG3 1124 7142
GNG4 858 6856
GNG5 4379 6512
GNG7 -3064 -499
GNGT2 859 7120
GRB2 4420 6241
GTPBP2 4332 4515
GYPC 1797 -1743
HABP4 -4533 3365
HDAC1 -207 3287
HDAC2 -1260 5864
HMG20B 937 1259
HRAS -2340 -823
INPP5D 3164 55
IRF1 -2390 5832
IRF2 3133 2365
ITGA1 2938 2777
ITGA2 -1026 -260
ITGA4 -3400 -394
ITGA5 3669 3467
ITGA6 -4267 5920
ITGAL 761 7038
ITGAV 2675 -370
ITGB2 4462 6426
ITPK1 4165 4524
ITPR1 -1851 1789
ITPR2 2474 -44
ITPR3 -2973 2189
JAK2 1159 6489
JAM2 -1189 5426
JMJD1C -397 2975
KCNMB4 -633 712
KDM1A -3046 5493
KIF11 1038 1895
KIF13B 3335 2528
KIF15 127 6309
KIF16B -1472 5965
KIF18A 75 3290
KIF18B 1780 5532
KIF1B 4248 1220
KIF20A 1510 1403
KIF20B -1753 4534
KIF21A -2976 -346
KIF21B 951 2388
KIF22 -4500 6183
KIF23 1200 805
KIF26B -3124 -1903
KIF27 1319 6076
KIF2A -2268 4006
KIF2C 1020 -12
KIF3A -4235 6174
KIF3B 1598 2018
KIF3C 3608 -1430
KIF5B 3295 4670
KIF6 834 2531
KIF9 2317 2418
KIFAP3 -995 -68
KIFC1 681 1767
KIFC2 -1378 2527
KLC1 2928 4386
KLC2 -2845 1505
KLC4 -2245 4367
KRAS 2245 3139
LCK -4408 7246
LCP2 1073 -428
LRP8 3271 4757
MAFF 312 6749
MAFG 4314 4552
MAFK 1094 -1176
MANF -167 6556
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
MFN1 -873 1048
MFN2 3356 -1030
MICAL1 4312 -904
MIF -2780 3355
MYB -86 -449
NFE2 4593 -1804
NHLRC2 -2038 -59
NOS3 -3550 4048
OLA1 -794 6473
ORAI1 -1998 2153
ORAI2 2958 -132
P2RX1 4648 -1949
P2RX4 2912 398
P2RX5 -3757 1377
P2RY1 4641 3720
PAFAH2 -1905 3736
PCYOX1L -793 2972
PDE1B 4090 -1314
PDE2A 1457 -1910
PDE5A 1311 3824
PDE9A -4136 -1809
PDPK1 3218 346
PFN1 3195 3814
PHACTR2 1822 -1839
PHF21A 4621 5215
PICK1 2559 1314
PIK3CA 946 1470
PIK3CG 3569 2051
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R3 995 3645
PIK3R5 1953 4483
PLAU 1259 -1529
PLAUR 4124 -861
PLCG1 -4367 958
PLCG2 3848 2803
PLEK 2137 -567
PPIA -1958 4555
PPIL2 -941 -350
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5A 3674 -230
PPP2R5B 3304 -286
PPP2R5C -1671 7074
PPP2R5D 2123 3470
PPP2R5E -4 1402
PRCP 3614 611
PRKACA 4634 890
PRKACB -4510 1712
PRKAR1A 4338 -432
PRKAR1B 1934 1230
PRKAR2A 3132 -874
PRKCA -1148 6894
PRKCB 3491 4964
PRKCD 4519 6360
PRKCE 2768 -1185
PRKCH -4342 2578
PRKCQ -4282 4208
PRKCZ -2913 -1376
PRTN3 -1895 5621
PSAP 3637 628
PTK2 -81 -475
PTPN1 4210 699
PTPN11 2499 5062
PTPN6 4000 6542
QSOX1 4636 5727
RAB5A 2871 3958
RAC1 4404 5541
RAC2 2815 4577
RACGAP1 2182 4089
RAD51B 4049 6320
RAF1 3220 6573
RAP1A 3123 6569
RAP1B 3135 5968
RASGRP1 -4340 5888
RASGRP2 -3066 -413
RBSN -220 6354
RCOR1 4284 -178
RHOA 3965 4033
RHOB 2718 2346
RHOG 4253 3664
S100A10 2598 5902
SCCPDH 4131 1126
SDC4 2632 2364
SELPLG 3316 -1614
SERPINB6 2494 2823
SERPINB8 3761 -793
SERPINE2 2253 -1730
SH2B1 -2743 1436
SH2B3 2478 3851
SHC1 3684 3205
SIN3A -2967 3819
SLC16A1 152 5451
SLC16A3 4572 -1654
SLC3A2 2791 744
SLC7A11 142 -895
SLC7A5 2267 -1904
SLC7A6 -3745 6043
SLC8A3 -912 -118
SOD1 -2469 1838
SOS1 -1564 -1986
SPN -2591 -1782
SRC -2136 -1476
SRGN 4080 1395
SRI 3139 -271
STIM1 3891 7265
STX4 2105 1609
STXBP2 4595 -155
STXBP3 2813 199
SYK 4235 431
TAGLN2 1373 1679
TEX264 -1487 5266
TGFB1 2241 3769
TGFB2 1216 -1899
TGFB3 -3044 -978
TLN1 4172 -983
TMX3 -1185 -543
TNFRSF10A -1831 2821
TNFRSF10B 2678 -670
TNFRSF10D 2388 3086
TOR4A 4489 -1620
TP53 -4050 2709
TUBA4A 2677 4105
VAV1 3798 5834
VAV2 803 4134
VAV3 3247 -685
VCL 2594 3614
VEGFA 2025 87
VPS45 -153 3197
VTI1B 3649 3178
WDR1 3933 7036
WEE1 -1233 5101
YES1 -1029 5198
YWHAZ 2353 4294
ZFPM1 -1229 6831



Signaling by Interleukins

Signaling by Interleukins
metric value
setSize 262
pMANOVA 1.36e-12
p.adjustMANOVA 4.76e-11
s.dist 0.259
s.RNA 0.233
s.meth 0.114
p.RNA 1.2e-10
p.meth 0.00169




Top 20 genes
Gene RNA meth
SOCS3 4419 6492
ITGB2 4462 6426
TNFRSF1B 4053 6870
MAPK1 4560 6099
CRK 4199 6598
GRB2 4420 6241
PTPN9 4524 6096
PTPN6 4000 6542
NOD2 3807 6610
IRS2 3955 6152
ALOX5 4460 5386
P4HB 4143 5718
IL19 3167 7266
VAV1 3798 5834
SMARCA4 3223 6792
PSMA7 3130 6903
MAP2K6 4437 4792
PSMD4 3947 5314
IL18R1 3014 6744
PTK2B 4451 4529

Click HERE to show all gene set members

All member genes
RNA meth
AIP -657 6684
AKT1 1891 1109
ALOX5 4460 5386
APP 2952 6623
ARF1 4345 -1821
ATF1 1229 2989
BATF 1760 6679
BCL2 -3030 7022
BCL2L1 1477 5970
BCL6 4540 3669
BIRC5 2356 1965
BRWD1 -2774 -349
BTRC -1864 -923
CANX 1895 3479
CAPZA1 3861 999
CASP1 1192 7031
CASP3 2079 5691
CBL 3732 1012
CCND1 -2034 1006
CCR1 3886 -1921
CD4 -2816 909
CDC42 3449 856
CDKN1A 2283 2427
CEBPD 4308 -907
CFL1 3970 1646
CHUK 3354 1111
CISH -1047 4928
CNN2 2979 -418
CREB1 -1458 1422
CRK 4199 6598
CRKL 1455 5167
CSF1 -551 356
CTF1 2571 543
CUL1 -4005 -1192
CXCL2 440 -1990
DUSP3 2975 2260
DUSP4 -384 2494
DUSP6 -702 -1943
DUSP7 -732 722
FBXW11 2170 -1508
FOS 692 5647
FOXO1 -4458 3034
FOXO3 3816 5023
FYN -1686 2793
GAB2 4007 2390
GATA3 -4581 6274
GRB2 4420 6241
GSTO1 3901 3633
HIF1A 3440 2448
HMGB1 -1409 3222
HNRNPA2B1 979 2721
HNRNPF 839 5857
HSP90AA1 -729 6210
HSP90B1 -436 2127
HSPA9 -4169 6551
ICAM1 170 2036
IKBKB -510 -912
IL10RA -106 5518
IL10RB 4566 -1076
IL12A -3557 -1317
IL12RB1 -2265 6632
IL12RB2 -3177 -1861
IL15 -1033 3611
IL15RA 67 -1087
IL16 -1859 5458
IL17C 1334 -1130
IL17RA 4468 130
IL17RC -1500 1939
IL18BP -1294 -1640
IL18R1 3014 6744
IL19 3167 7266
IL1RAP 3464 -1122
IL21R -3300 2722
IL23A -4577 7078
IL27RA 1558 6659
IL2RA -2715 6868
IL2RB -4098 7237
IL32 -4046 7268
IL4R 3584 1274
IL6R 2774 5066
IL6ST -361 1708
INPP5D 3164 55
INPPL1 3940 588
IRAK2 -1227 4686
IRAK3 4491 666
IRF4 -3348 5941
IRS1 -2666 4308
IRS2 3955 6152
ITGB2 4462 6426
JAK1 -2308 -283
JAK2 1159 6489
JUN -400 1283
JUNB 2048 5018
LCK -4408 7246
LCP1 4185 4312
LGALS9 3845 -1462
LMNB1 4349 1051
MAP2K1 4239 1533
MAP2K3 4152 2411
MAP2K4 2698 4764
MAP2K6 4437 4792
MAP2K7 -54 1764
MAP3K3 4145 3121
MAP3K7 1566 -147
MAP3K8 4603 3266
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
MAPK7 3610 -244
MAPK8 -3916 4554
MAPK9 -1532 157
MAPKAPK2 3498 3265
MAPKAPK3 4597 2896
MEF2A 3826 3013
MIF -2780 3355
MTAP -2689 2271
MUC1 1680 6715
MYD88 4594 1945
NFKB2 -2276 5251
NFKBIA 1525 6814
NFKBIB 2303 5574
NKIRAS1 -1505 348
NKIRAS2 4544 -1132
NOD1 -1776 -321
NOD2 3807 6610
OSM 2650 1355
P4HB 4143 5718
PAK2 3574 283
PDCD4 -4504 4220
PELI1 1886 1867
PELI2 2557 7035
PELI3 3582 -1123
PIK3CA 946 1470
PIK3CD 2671 6109
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R3 995 3645
PIM1 2364 1390
PITPNA 3938 3616
POU2F1 2656 3909
PPIA -1958 4555
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5D 2123 3470
PRKACA 4634 890
PRTN3 -1895 5621
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PTK2B 4451 4529
PTPN11 2499 5062
PTPN12 3373 -982
PTPN13 -2147 6850
PTPN18 4484 3436
PTPN2 3642 181
PTPN23 1520 5427
PTPN4 -3841 784
PTPN6 4000 6542
PTPN7 -570 2323
PTPN9 4524 6096
RALA -2065 2302
RAP1B 3135 5968
RAPGEF1 1580 6445
RBX1 2032 5883
RELA -360 4333
RORA -4196 6933
RPLP0 -3580 4851
RPS27A -4269 2589
RPS6KA1 4497 -1859
RPS6KA2 1476 2117
RPS6KA5 -4234 1991
S1PR1 -1875 6791
SHC1 3684 3205
SIGIRR -2919 6807
SKP1 -1442 2680
SMAD3 -3734 -363
SMARCA4 3223 6792
SNRPA1 -3020 1539
SOCS1 1954 4130
SOCS2 -1172 6479
SOCS3 4419 6492
SOCS5 -381 466
SOD1 -2469 1838
SOD2 2190 6134
SOS1 -1564 -1986
SOS2 3721 3699
SQSTM1 -377 658
STAT1 -4254 4970
STAT2 -1754 5933
STAT3 3772 4995
STAT4 -4008 4203
STAT5A 2951 -1545
STAT5B 2832 1495
STAT6 3358 3854
STX1A 1013 4174
STX3 3765 2712
STX4 2105 1609
STXBP2 4595 -155
SYK 4235 431
TAB2 605 6401
TALDO1 4236 4422
TBK1 2175 599
TCP1 -1018 -448
TEC 3744 170
TGFB1 2241 3769
TNF -1302 -526
TNFRSF1A 4400 -1548
TNFRSF1B 4053 6870
TNIP2 2642 287
TOLLIP 3698 664
TP53 -4050 2709
TRAF6 957 -71
TXLNA -114 7007
TYK2 3852 4072
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
UBE2N -315 4834
UBE2V1 688 2792
VAMP2 -3963 -1239
VAV1 3798 5834
VEGFA 2025 87
VIM 4522 3780
VRK3 2298 2903
YES1 -1029 5198
YWHAZ 2353 4294
ZEB1 -3353 5937



Metabolism of lipids

Metabolism of lipids
metric value
setSize 427
pMANOVA 3.37e-12
p.adjustMANOVA 1.14e-10
s.dist 0.21
s.RNA 0.206
s.meth -0.0372
p.RNA 4.92e-13
p.meth 0.194




Top 20 genes
Gene RNA meth
GGT1 4656 -1937
TBXAS1 4590 -1853
ARF1 4345 -1821
NCOR2 4562 -1609
CHPT1 3946 -1714
AGPAT2 4525 -1388
ARSB 4014 -1528
SQLE 3747 -1595
ALOX5AP 3746 -1566
PGS1 4220 -1358
TXNRD1 3917 -1402
GPD2 3500 -1558
SAMD8 2937 -1768
DHCR24 3846 -1295
HACD1 3096 -1445
GLTP 4364 -1009
CHKA 3437 -1259
PLD1 4582 -902
CPT1A 2489 -1598
DGAT2 4456 -892

Click HERE to show all gene set members

All member genes
RNA meth
AACS -514 5129
ABCA1 2550 -82
ABCC1 1913 -26
ABHD3 3124 2912
ABHD4 2986 574
ABHD5 3968 1319
ACAA1 4343 5790
ACACA 3369 1077
ACACB -2777 -519
ACAD10 2725 2091
ACAD11 -2326 5734
ACADM -2146 -637
ACADS 1969 -1452
ACAT1 300 4902
ACAT2 -2789 777
ACBD4 -2345 1001
ACBD5 2010 2753
ACBD6 -2544 372
ACBD7 1055 4804
ACER2 -1538 315
ACER3 4324 6816
ACLY 4076 2976
ACOT13 2681 2379
ACOT7 -607 6020
ACOT8 4106 5475
ACOX1 3939 4104
ACOX3 4072 5381
ACOXL 2506 7260
ACP6 -1483 5126
ACSF2 -783 3532
ACSF3 -20 4103
ACSL1 4473 6607
ACSL3 3578 -732
ACSL5 -1350 2404
ACSL6 -4396 7278
ACSM3 -3405 698
AGK -3991 492
AGPAT1 2852 5849
AGPAT2 4525 -1388
AGPAT3 3024 637
AGPAT4 2668 -315
AGPAT5 -4228 5438
AGPS 1993 -195
AHR 1322 5027
AHRR -689 6738
AKR1B1 -4518 4190
ALDH3A2 576 5655
ALOX5 4460 5386
ALOX5AP 3746 -1566
AMACR -544 6130
ARF1 4345 -1821
ARF3 3661 274
ARNT 4004 4409
ARNTL 1437 1097
ARSA 2606 523
ARSB 4014 -1528
ARSG 29 4004
ARSK -4532 4078
ARV1 783 6971
ASAH1 4412 2174
BDH1 -4294 796
BDH2 -3738 -1583
CAV1 249 4592
CBR4 116 2046
CCNC -2266 4188
CDIPT 1681 2141
CDK19 3707 975
CDK8 795 5795
CDS2 2653 540
CEPT1 -107 169
CERK -2177 -203
CERS5 1955 -1210
CERS6 1894 -762
CHD9 488 -1054
CHKA 3437 -1259
CHKB -603 6851
CHPT1 3946 -1714
CLOCK -2225 3525
CPNE1 -985 5132
CPNE3 1782 -1443
CPT1A 2489 -1598
CPT2 4459 -446
CPTP 1472 5330
CRAT 3593 2473
CREBBP 2340 892
CRLS1 3160 6323
CSNK1G2 873 2563
CSNK2A2 2821 5736
CSNK2B 1983 4743
CTSA 4474 2720
CYP2R1 -192 3262
CYP2U1 -3234 3858
CYP46A1 883 3979
CYP4F22 1536 5603
CYP51A1 3611 -89
DBI 3142 1598
DDHD1 -3486 4148
DDHD2 -4347 687
DECR1 2753 3217
DECR2 640 3974
DEGS1 1764 3203
DGAT1 1176 -576
DGAT2 4456 -892
DHCR24 3846 -1295
DHCR7 3494 4809
DHRS7B 4006 345
DPEP2 403 -1338
ECHS1 -2129 3252
ECI1 -825 -1283
ECI2 -4272 296
EHHADH 3462 2918
ELOVL1 3760 6602
ELOVL4 -4575 3377
ELOVL5 1786 2656
ELOVL6 -785 521
EP300 3478 4901
EPHX2 -4596 -695
ESRRA 3561 5421
ESYT1 -4436 4321
ESYT2 -4056 1696
ETNK1 -191 5868
FABP5 2835 2233
FADS1 4216 3002
FADS2 2563 -779
FAM120B 2582 -222
FAR1 3562 313
FASN -1486 4278
FDFT1 3403 3920
FDPS 2492 4338
FDX1 -351 3052
FDXR 1212 1657
FIG4 4371 6859
FITM2 -3414 910
GALC 4504 4245
GBA 4602 45
GBA2 2891 -583
GDE1 3469 5340
GDPD1 -350 3142
GDPD5 -2705 235
GGPS1 -1085 541
GGT1 4656 -1937
GLB1 4153 1828
GLIPR1 1534 5593
GLTP 4364 -1009
GM2A 4470 6363
GPAM -3807 81
GPCPD1 3854 7103
GPD1 -1078 -633
GPD1L -3016 -403
GPD2 3500 -1558
GPS2 444 6830
GPX1 2758 -875
GPX4 1592 4419
GSTM4 1619 2362
HACD1 3096 -1445
HACD2 -1887 6437
HACD3 -4386 3440
HACD4 1985 6326
HACL1 -4226 3807
HADH -4186 -364
HADHA 2510 2805
HADHB 4195 3179
HDAC3 1734 7116
HEXA -322 5238
HEXB 3333 2906
HILPDA -950 1618
HMGCL 3907 6683
HMGCR 3159 4522
HMGCS1 260 3457
HPGD 3779 6954
HSD17B1 -830 2592
HSD17B11 2022 5772
HSD17B12 1816 5884
HSD17B4 3556 2004
HSD17B8 -3297 5823
IDI1 3278 2766
INPP4A 551 5041
INPP5D 3164 55
INPP5E -3575 496
INPP5F 278 3598
INPP5K 943 2453
INPPL1 3940 588
INSIG1 2350 3015
INSIG2 2577 -1219
KPNB1 1964 1140
LBR 3405 2128
LCLAT1 -512 4863
LGMN -2658 2706
LIPE -3796 5509
LPCAT1 2522 1418
LPCAT3 4362 1514
LPCAT4 -2678 2192
LPGAT1 3844 -464
LPIN1 -2848 2315
LPIN2 -2371 6919
LSS -2558 -719
LTA4H 4283 798
LTC4S -778 -1874
MAPKAPK2 3498 3265
MBOAT1 2345 500
MBOAT7 4126 4179
MBTPS1 1497 2401
MCAT 505 4956
MCEE -1263 1366
MECR -1567 6054
MED1 -534 4473
MED10 -3454 2697
MED11 125 5168
MED13 301 6580
MED13L 3399 5940
MED15 -879 5803
MED16 1233 -884
MED17 -1374 3538
MED18 3102 -268
MED19 -444 2674
MED20 3086 180
MED21 -2101 4075
MED22 242 -1308
MED23 -599 3755
MED24 -359 5183
MED25 2513 565
MED26 2289 3021
MED27 -253 1874
MED28 -902 219
MED29 -1590 -373
MED30 -1116 4136
MED31 -984 2499
MED4 61 127
MED6 -1765 6745
MED7 539 4941
MED8 3196 1234
MED9 -496 1721
MFSD2A -2692 -1143
MLYCD -407 3456
MMAA -2576 6866
MORC2 -4070 7284
MSMO1 1504 5195
MTF1 4342 5712
MTMR10 3116 6805
MTMR12 1645 4654
MTMR14 3488 3137
MTMR2 -942 1909
MTMR3 4500 613
MTMR4 1935 3784
MTMR6 3285 2060
MTMR9 1355 4286
MVD 1014 190
MVK 507 3791
NCOA2 2227 2432
NCOA3 2264 3815
NCOA6 3952 419
NCOR1 3183 -530
NCOR2 4562 -1609
NDUFAB1 -707 4045
NEU1 4492 1899
NEU3 -818 -1014
NFYA 699 102
NFYB -4572 1588
NFYC 3999 226
NR1D1 -4199 5907
NR1H2 3489 6463
NR1H3 1154 6206
NRF1 -392 -1257
NUDT19 3301 6786
NUDT7 322 3989
ORMDL1 -1536 5782
ORMDL3 -2693 3085
OSBP 684 370
OSBPL2 3263 2403
OSBPL3 -3885 1202
OSBPL5 62 -1848
OSBPL7 -3372 -1677
OSBPL8 1671 4416
OSBPL9 2666 3235
OXCT1 -4366 3313
PCCB -1393 -1153
PCTP 3878 6638
PCYT1A 3627 5272
PCYT2 -2635 -368
PECR 3517 6201
PEMT -881 5572
PEX11A 237 3970
PGS1 4220 -1358
PHOSPHO1 2747 5611
PI4K2A 2669 5682
PI4K2B -4148 2370
PI4KA 986 2317
PI4KB 220 5395
PIAS4 3189 1744
PIK3CA 946 1470
PIK3CD 2671 6109
PIK3CG 3569 2051
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R3 995 3645
PIK3R4 -1326 2170
PIK3R5 1953 4483
PIKFYVE 1248 -725
PIP4K2A 790 3045
PIP4K2B -2669 1071
PIP4K2C -716 223
PIP5K1A 1819 4436
PIP5K1C 2641 3895
PISD 4071 -888
PITPNB -1922 4752
PITPNM1 4160 3850
PITPNM2 -612 7241
PITPNM3 215 6590
PLA2G12A -457 767
PLA2G15 4512 3624
PLA2G4C -2071 3866
PLA2G6 -3342 826
PLB1 4655 -114
PLD1 4582 -902
PLD3 2082 354
PLD6 -4194 5490
PLEKHA2 818 -1137
PLEKHA3 -252 -1381
PLEKHA6 1310 -1434
PLEKHA8 -1448 -788
PLIN2 4022 1747
PLIN3 4612 23
PMVK 1498 3437
PNPLA2 3862 281
PNPLA6 4280 2173
PNPLA7 -2335 1447
PNPLA8 2695 -143
PON2 -1728 -1456
PPARD -3709 -791
PPARGC1B 34 1449
PPM1L 2249 6865
PPP1CA 2370 4238
PPP1CB 2691 -340
PPP1CC 1107 5379
PPT1 4115 1132
PPT2 -3071 -1409
PRKAB2 -2556 3091
PRKACA 4634 890
PRKACB -4510 1712
PRKAG2 -201 1021
PRKD2 -282 5530
PSAP 3637 628
PTDSS2 426 2429
PTEN 3783 4815
PTGES2 -2631 -901
PTGES3 -943 4287
PTGR1 4454 183
PTGR2 641 -1417
PTPMT1 663 -467
PTPN13 -2147 6850
RAB14 2619 -378
RAB4A 480 559
RAB5A 2871 3958
RAN -3182 1483
RGL1 4405 3381
RORA -4196 6933
RUFY1 1859 317
SACM1L -1945 2312
SAMD8 2937 -1768
SAR1B 2728 3060
SBF1 -1870 3727
SC5D -1032 -891
SCAP -1479 -731
SCD 2700 -1082
SCP2 788 6351
SEC23A 2702 1833
SEC24A 3575 4762
SEC24B 2183 -13
SEC24C 2332 -336
SEC24D 4409 1527
SGMS1 3622 4256
SGPL1 3896 -1015
SGPP1 -1137 -665
SIN3A -2967 3819
SIN3B -18 -419
SLC22A5 1948 5708
SLC25A1 2389 4558
SLC25A17 -3683 -379
SLC25A20 3493 4787
SLC27A1 2174 1124
SLC27A2 -1491 -1411
SLC27A3 717 7018
SLC27A5 -193 -1574
SLC44A1 2845 924
SLC44A2 1805 4323
SMPD1 1902 6502
SMPD2 780 6784
SMPD3 -2987 7226
SP1 3396 4865
SPHK2 1998 670
SPTLC1 3724 3337
SPTLC2 3922 1289
SPTLC3 1096 -1650
SPTSSA 383 -193
SQLE 3747 -1595
SRD5A1 3258 6932
SRD5A3 2617 2696
SREBF1 387 2475
SREBF2 3415 4296
STARD10 -581 3166
STARD3 1992 3852
STARD3NL 3141 2506
STARD4 567 -100
STARD5 1627 1237
STARD7 1519 5188
SUMF1 4171 -728
SUMF2 -2533 38
SYNJ1 4109 2804
SYNJ2 -3998 -505
TBL1XR1 1687 2633
TBXAS1 4590 -1853
TECR -3512 5770
THEM4 -4605 809
TIAM2 765 -1147
TM7SF2 -3261 1399
TNFAIP8 -3619 4923
TNFAIP8L1 -3483 1829
TNFAIP8L2 1190 -165
TRIB3 207 3767
TSPO 4326 6747
TXNRD1 3917 -1402
UBE2I 14 5796
UGCG 2916 3873
VAC14 2071 2508
VAPA 3892 4246
VAPB 167 -1989
VDR 4632 3980



Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation
metric value
setSize 133
pMANOVA 4.94e-12
p.adjustMANOVA 1.63e-10
s.dist 0.358
s.RNA 0.351
s.meth 0.0679
p.RNA 3.17e-12
p.meth 0.178




Top 20 genes
Gene RNA meth
PRKCD 4519 6360
GNG5 4379 6512
MAPK1 4560 6099
CRK 4199 6598
WDR1 3933 7036
GRB2 4420 6241
QSOX1 4636 5727
CYB5R1 4477 5881
PTPN6 4000 6542
ACTN1 3577 7240
CD63 4635 5434
RAC1 4404 5541
ALDOA 4426 5367
FERMT3 4479 5112
VAV1 3798 5834
RAF1 3220 6573
RAP1A 3123 6569
GTPBP2 4332 4515
APP 2952 6623
RAP1B 3135 5968

Click HERE to show all gene set members

All member genes
RNA meth
A1BG -376 567
AAMP -2190 7121
ABCC4 1768 2355
ABHD12 -1193 5950
ABHD6 3026 2533
ACTN1 3577 7240
ACTN4 4164 1596
AKT1 1891 1109
ALDOA 4426 5367
ANXA5 3811 2872
APBB1IP 4238 3821
APLP2 4509 -964
APP 2952 6623
ARRB1 1885 -1278
ARRB2 4237 2913
BRPF3 -744 3308
CALM1 263 4502
CALU 3586 1962
CAP1 3919 2034
CD63 4635 5434
CDC37L1 -3085 519
CDC42 3449 856
CFL1 3970 1646
CHID1 494 1830
CRK 4199 6598
CSK 3371 4890
CYB5R1 4477 5881
DAGLB 4077 -302
DGKA -4082 7033
DGKD 1369 4806
DGKE -3850 6507
DGKG 3273 4393
DGKH -1084 4127
DGKQ -641 3114
DGKZ -1261 -1315
ENDOD1 715 -639
FAM3C -4121 32
FERMT3 4479 5112
FYN -1686 2793
GNA12 -49 4303
GNA13 2128 3330
GNA15 4439 -1924
GNAI2 4151 3218
GNAI3 3381 2359
GNAQ 3913 -1832
GNB1 4261 2799
GNB2 4032 1879
GNB4 3205 1335
GNB5 -1662 6256
GNG2 1513 6500
GNG3 1124 7142
GNG4 858 6856
GNG5 4379 6512
GNG7 -3064 -499
GNGT2 859 7120
GRB2 4420 6241
GTPBP2 4332 4515
HABP4 -4533 3365
ITPR1 -1851 1789
ITPR2 2474 -44
ITPR3 -2973 2189
LCK -4408 7246
LCP2 1073 -428
MANF -167 6556
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
NHLRC2 -2038 -59
OLA1 -794 6473
P2RY1 4641 3720
PCYOX1L -793 2972
PDPK1 3218 346
PFN1 3195 3814
PHACTR2 1822 -1839
PIK3CA 946 1470
PIK3CG 3569 2051
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R3 995 3645
PIK3R5 1953 4483
PLCG2 3848 2803
PLEK 2137 -567
PPIA -1958 4555
PRKCA -1148 6894
PRKCB 3491 4964
PRKCD 4519 6360
PRKCE 2768 -1185
PRKCH -4342 2578
PRKCQ -4282 4208
PRKCZ -2913 -1376
PSAP 3637 628
PTK2 -81 -475
PTPN1 4210 699
PTPN11 2499 5062
PTPN6 4000 6542
QSOX1 4636 5727
RAC1 4404 5541
RAC2 2815 4577
RAF1 3220 6573
RAP1A 3123 6569
RAP1B 3135 5968
RASGRP1 -4340 5888
RASGRP2 -3066 -413
RHOA 3965 4033
RHOB 2718 2346
RHOG 4253 3664
SCCPDH 4131 1126
SHC1 3684 3205
SOD1 -2469 1838
SOS1 -1564 -1986
SRC -2136 -1476
SRGN 4080 1395
STX4 2105 1609
STXBP2 4595 -155
STXBP3 2813 199
SYK 4235 431
TAGLN2 1373 1679
TEX264 -1487 5266
TGFB1 2241 3769
TGFB2 1216 -1899
TGFB3 -3044 -978
TLN1 4172 -983
TMX3 -1185 -543
TOR4A 4489 -1620
TUBA4A 2677 4105
VAV1 3798 5834
VAV2 803 4134
VAV3 3247 -685
VCL 2594 3614
VEGFA 2025 87
VTI1B 3649 3178
WDR1 3933 7036
YWHAZ 2353 4294



Gene expression (Transcription)

Gene expression (Transcription)
metric value
setSize 1004
pMANOVA 1.07e-11
p.adjustMANOVA 3.44e-10
s.dist 0.141
s.RNA -0.118
s.meth 0.0785
p.RNA 1.02e-09
p.meth 4.73e-05




Top 20 genes
Gene RNA meth
RGCC -4492 7232
TCF7 -4620 6951
NUP88 -4449 7084
NDC1 -4582 6482
RORA -4196 6933
ZNF517 -4213 6892
GATA3 -4581 6274
ZNF681 -4297 6567
RPA1 -4364 6282
WRN -4354 6296
NFATC2 -3732 7159
FBXO32 -4013 6488
ZNF563 -4027 6436
ZNF530 -4543 5650
NOP2 -3984 6403
DGCR8 -3639 6998
ZNF75A -3586 7086
ZNF571 -3704 6813
NR1D1 -4199 5907
POLR3H -4401 5546

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1807 1467
ABL1 1975 2469
ACTB 4359 5447
ACTL6A -3054 -311
AEBP2 -2718 6374
AFF4 1342 -209
AGO1 3338 7140
AGO2 1363 7196
AGO3 384 3465
AKT1 1891 1109
AKT2 781 5431
ALYREF 452 6737
ANAPC1 -4482 2990
ANAPC10 -418 -1326
ANAPC11 1271 3188
ANAPC15 3233 6483
ANAPC16 -2423 6729
ANAPC2 -2051 2865
ANAPC4 -1105 -687
ANAPC5 -2994 5213
ANAPC7 175 1873
APAF1 3421 -809
ARID1A 3217 1914
ARID1B -300 4017
ARID2 819 1091
ARID3A 3991 2011
ARID4B 845 2402
ASH2L 3680 3075
ATAD2 -1775 142
ATM -3839 3035
ATR -2449 930
ATRIP -2244 1869
ATXN3 473 2715
AURKA 2658 4012
AURKB 1284 5274
AUTS2 -2047 -1353
AXIN1 -1579 -858
BANP 132 195
BARD1 1240 5972
BAX 1666 1161
BAZ1B 89 1271
BAZ2A 1875 3649
BBC3 -682 5286
BCDIN3D -14 3632
BCL2L11 3447 5664
BCL6 4540 3669
BDP1 -1560 6073
BID 2614 5466
BIRC5 2356 1965
BLM -1597 5263
BMI1 -3702 -805
BNIP3L 2168 4412
BRCA1 2623 1586
BRD1 -2827 7212
BRD2 -1457 5081
BRD7 -511 3924
BRF1 -503 2464
BRF2 -1188 2460
BRIP1 -2451 63
BRPF1 -332 5935
BRPF3 -744 3308
BTG1 -1401 5954
BTG2 -2187 5261
CALM1 263 4502
CAMK2D -4530 -529
CAMK2G -152 6718
CAMK4 -4622 2759
CASC3 3110 5106
CASP1 1192 7031
CASP10 216 -1807
CASP6 -2547 -556
CAT 4134 -1206
CAV1 249 4592
CBFB 863 5862
CBX3 1326 2289
CBX4 2029 278
CBX6 2054 3612
CBX8 1089 4611
CCNA2 256 4428
CCNB1 360 1332
CCNC -2266 4188
CCND1 -2034 1006
CCND2 -4129 -1567
CCND3 4303 4156
CCNE1 -2341 5956
CCNE2 1467 5659
CCNG1 -1620 857
CCNG2 3391 2810
CCNH 645 1260
CCNK 2948 6593
CCNT1 -1783 1761
CD3EAP -3357 5515
CDC16 -1889 3340
CDC23 -3699 1597
CDC25C 1516 5507
CDC40 2326 7125
CDC7 -1873 6399
CDC73 2258 5719
CDK1 -309 1888
CDK12 1125 5160
CDK13 436 5779
CDK2 -1525 2965
CDK4 -4099 4919
CDK5 4361 3491
CDK5R1 202 7124
CDK6 -2288 562
CDK7 2068 4034
CDK8 795 5795
CDK9 1688 3144
CDKN1A 2283 2427
CDKN1B -1212 3367
CDKN2A -149 3478
CEBPB 4463 337
CENPJ -4058 4073
CHD3 -3189 6050
CHD4 -63 640
CHEK1 -1742 51
CHEK2 -697 5331
CITED2 2991 1266
CITED4 1359 -93
CLP1 2017 2378
CNOT1 1059 4959
CNOT10 -194 3018
CNOT11 246 3729
CNOT3 1882 3093
CNOT4 702 6001
CNOT6 2546 4653
CNOT6L -3217 6262
CNOT7 -3636 -58
CNOT8 1626 5798
COX11 -4293 2566
COX14 -2107 6534
COX16 -1797 1183
COX19 -1968 47
COX20 -2968 4917
COX4I1 369 6762
COX5A 1733 -152
COX5B 2073 -52
COX6A1 2109 3077
COX6B1 2794 564
COX6C -1077 2304
COX7A2L 2193 5084
COX7C -1240 1883
COX8A 3158 2226
CPSF1 -446 1083
CPSF2 2904 988
CPSF3 3136 5337
CPSF4 -1522 1770
CRADD 1839 1024
CRCP 2844 4708
CREB1 -1458 1422
CREBBP 2340 892
CSNK2A2 2821 5736
CSNK2B 1983 4743
CSTF1 -2757 6209
CTDP1 3594 1002
CTLA4 -3441 7091
CTNNB1 3473 5070
CTR9 896 -440
CTSL 4277 3028
CTSV -1816 5170
CUL1 -4005 -1192
CYCS -700 5369
DAXX -1271 1574
DDB2 -147 -1223
DDIT3 1573 5192
DDIT4 2139 3702
DDX21 510 3312
DEK 145 6182
DGCR8 -3639 6998
DICER1 3790 6637
DNA2 -2282 1296
DNMT1 -4341 4753
DNMT3A -1828 -1253
DNMT3B 1206 3249
DPY30 533 1423
DYRK2 -4502 4997
E2F1 2365 3145
E2F4 1569 1015
E2F5 -3126 4181
E2F6 -3847 4027
E2F7 -1863 3875
E2F8 462 149
EAF1 2419 -327
EED -2862 3088
EHMT1 -17 2699
EHMT2 -1503 3889
EIF4A3 1061 4598
ELF1 629 -1467
ELF2 2096 978
ELL 2401 1501
ELL2 1679 167
ELL3 441 2028
EP300 3478 4901
EPC1 -3581 6722
ERBB2 -2008 4160
ERCC2 1784 1849
ERCC3 -87 1487
ERCC6 -2974 2399
ESR2 -3413 4784
ESRRA 3561 5421
EXO1 -1138 4438
EZH2 -920 2695
FANCC -1220 1401
FANCD2 -4077 4786
FANCI -2852 1261
FAS 1070 825
FBXO32 -4013 6488
FBXW7 -1004 6667
FIP1L1 -540 3099
FKBP5 4561 -681
FOS 692 5647
FOXO1 -4458 3034
FOXO3 3816 5023
FYTTD1 -1643 5127
FZR1 564 2326
GADD45A 4551 2249
GATA3 -4581 6274
GATAD2A 2102 189
GATAD2B 1474 5595
GLS -4609 2305
GPAM -3807 81
GPI 3145 5674
GPS2 444 6830
GSK3B 2685 4908
GSR 4556 4125
GTF2A1 204 1479
GTF2A2 1604 286
GTF2B 999 -1154
GTF2E2 2927 4885
GTF2F1 2455 558
GTF2F2 2495 5307
GTF2H3 -3181 5705
GTF2H4 -953 5240
GTF2H5 613 3417
GTF3A -3617 2860
GTF3C1 1872 4216
GTF3C2 -2032 2569
GTF3C3 -835 75
GTF3C4 -2387 7164
GTF3C5 -535 3843
GTF3C6 2013 3594
HDAC1 -207 3287
HDAC10 413 4924
HDAC11 1672 6084
HDAC2 -1260 5864
HDAC3 1734 7116
HDAC4 4304 887
HDAC5 903 3068
HDAC7 1275 -487
HENMT1 -183 5055
HIPK1 3112 4886
HIPK2 4260 7093
HIVEP3 272 6938
HSP90AA1 -729 6210
HSPD1 -4289 3524
HUS1 311 329
ICE2 -3721 5838
IL2RA -2715 6868
ING2 489 1059
ING5 -4481 4790
INTS1 1410 -478
INTS10 431 16
INTS12 1766 3211
INTS2 315 -1195
INTS3 3054 4013
INTS4 -2375 5759
INTS5 -2144 4248
INTS6 1631 1940
INTS7 902 4770
INTS8 1395 4191
INTS9 -789 200
IPO8 2000 3771
ITCH 2362 4854
ITGA4 -3400 -394
ITGA5 3669 3467
ITGAL 761 7038
IWS1 3236 3898
JARID2 3334 -106
JMY -3808 5163
JUN -400 1283
JUNB 2048 5018
KAT2A -4179 1343
KAT2B -105 4028
KAT5 1382 1952
KCTD1 1842 2461
KCTD6 2053 -621
KMT2A -3042 7244
KMT2C 1585 6984
KMT2D 2624 6495
KMT2E -36 7066
KRAS 2245 3139
L3MBTL2 -3725 2967
LAMTOR1 3714 -1589
LAMTOR2 3191 -1342
LAMTOR3 2265 957
LAMTOR4 1751 7000
LAMTOR5 3448 -881
LBR 3405 2128
LDB1 -2835 1166
LEO1 197 4252
LMO2 3802 2867
LRPPRC -4476 1082
LSM10 2140 1062
LSM11 -4170 -211
MAF -2162 403
MAML1 2981 1442
MAML2 -3215 4627
MAML3 4174 3460
MAP2K6 4437 4792
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
MAPKAP1 1834 5908
MAX 313 1615
MBD2 3424 -303
MBD3 -2156 6240
MDC1 -3376 4410
MDM2 2338 2095
MDM4 -209 5729
MEAF6 -2724 3083
MED1 -534 4473
MED10 -3454 2697
MED13 301 6580
MED15 -879 5803
MED16 1233 -884
MED17 -1374 3538
MED20 3086 180
MED23 -599 3755
MED24 -359 5183
MED25 2513 565
MED26 2289 3021
MED27 -253 1874
MED30 -1116 4136
MED31 -984 2499
MED4 61 127
MED6 -1765 6745
MED7 539 4941
MED8 3196 1234
MEN1 -2694 1903
MGA -2636 -909
MLLT1 4027 4011
MLLT3 -4429 1331
MLST8 -394 2258
MNAT1 -1772 1516
MOV10 -2729 -1882
MSH2 -3391 5927
MTA2 80 5579
MTA3 -3543 5162
MTERF1 -2131 5746
MTF2 -1732 3354
MTOR -141 3900
MYB -86 -449
MYBBP1A -4489 5091
MYBL1 -2673 3880
NABP1 3975 6497
NABP2 476 -1674
NBN 950 4478
NCBP1 -1093 5859
NCBP2 -4299 4777
NCOR1 3183 -530
NCOR2 4562 -1609
NDC1 -4582 6482
NDRG1 3894 1648
NDUFA4 2065 4279
NEDD4L 2846 -1080
NELFA -1404 3055
NELFB 829 -649
NELFCD -2102 6416
NELFE 2312 1529
NFATC2 -3732 7159
NFE2 4593 -1804
NFIA 3343 264
NFIC 4306 -1029
NFIX -747 424
NFYA 699 102
NFYB -4572 1588
NFYC 3999 226
NOP2 -3984 6403
NOTCH1 2941 6291
NOTCH4 3739 4962
NR1D1 -4199 5907
NR1D2 -4379 520
NR1H2 3489 6463
NR1H3 1154 6206
NR2C1 -3321 4894
NR2C2 -1114 7005
NR2C2AP -4317 3955
NR3C1 973 3509
NR3C2 -4466 5083
NR4A1 -431 1085
NR4A2 -870 3570
NR4A3 -1490 1460
NR6A1 3375 -1396
NRBP1 2511 5632
NUDT21 -3035 4271
NUP107 -3437 6301
NUP133 -2181 935
NUP153 -709 4344
NUP155 -3052 3043
NUP160 -3890 1293
NUP188 -3651 2922
NUP205 -3468 1670
NUP210 -1977 690
NUP214 3636 4369
NUP35 -4479 -557
NUP37 126 3398
NUP43 -3608 6346
NUP50 1354 6706
NUP54 -3105 831
NUP62 -1130 4609
NUP85 -1192 4518
NUP88 -4449 7084
NUP93 -2021 2006
NUP98 1358 -747
PABPN1 -414 3061
PAF1 1581 7080
PAPOLA 1641 4317
PARP1 -3863 3582
PBRM1 1889 3867
PCBP4 -3309 6284
PCGF5 -3402 1347
PCGF6 -347 2693
PCNA -2610 4383
PDPK1 3218 346
PHAX -2471 5545
PHC1 -3966 -1213
PHC2 4569 4887
PHC3 -1507 4977
PHF1 -4100 1265
PHF19 598 -358
PHF20 -1024 115
PIDD1 -2524 -453
PIN1 -43 4014
PINK1 4082 -715
PIP4K2A 790 3045
PIP4K2B -2669 1071
PIP4K2C -716 223
PLAGL1 1649 -782
PLD6 -4194 5490
PLK2 -304 5974
PLK3 1855 3378
PMAIP1 -4468 -1394
PML -714 4575
PMS2 -1363 5491
POLDIP3 3905 3182
POLR1A -1930 131
POLR1B -3876 5607
POLR1C -4305 5329
POLR1D 1066 6782
POLR1E -4511 1955
POLR2A 2412 4046
POLR2B -903 5563
POLR2C -520 6356
POLR2D -2238 -614
POLR2E 2119 3712
POLR2F 1375 509
POLR2G 1618 1604
POLR2H -2765 6299
POLR2I -1337 5657
POLR2K -1277 3853
POLR3A -15 5226
POLR3C -1330 3978
POLR3D -4218 1967
POLR3E -4103 1113
POLR3F -2735 -1023
POLR3G -1938 6661
POLR3GL -439 204
POLR3H -4401 5546
POLR3K -980 891
POLRMT -3804 2155
POM121 -1045 4681
POM121C -663 2061
POU2F1 2656 3909
POU2F2 1198 6367
PPARD -3709 -791
PPARGC1B 34 1449
PPM1A 3367 -136
PPM1D 2802 2649
PPP1R13B -3525 6430
PPP1R13L -2344 6545
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5C -1671 7074
PRDM1 -498 1144
PRDX1 1943 510
PRDX2 -1037 2503
PRDX5 3621 4022
PRKAA1 884 607
PRKAB1 2075 -840
PRKAB2 -2556 3091
PRKACA 4634 890
PRKAG1 3050 -1055
PRKAG2 -201 1021
PRKCB 3491 4964
PRKCQ -4282 4208
PRKRA -4388 2110
PRMT1 -3864 2118
PRMT5 159 2005
PRR5 -2935 -347
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PTEN 3783 4815
PTPN1 4210 699
PTPN11 2499 5062
PTPN4 -3841 784
RABGGTA 887 4691
RABGGTB -2900 7207
RAD1 -4521 -31
RAD17 -3871 5343
RAD50 -772 247
RAD51 -352 5267
RAD51D -2892 4330
RAD9A -3139 5967
RAD9B 1832 -246
RAE1 1241 2634
RAN -3182 1483
RANBP2 -757 5165
RARA 4270 2132
RARG -2176 297
RB1 3808 1119
RBBP4 -1544 4061
RBBP5 -425 2829
RBBP8 2859 1329
RBL1 -2744 5256
RBL2 -4334 -479
RBM14 -1287 5599
RBPJ 4163 1033
RBX1 2032 5883
RELA -360 4333
RFC2 2380 4262
RFC3 -4163 2737
RFC4 -4064 5077
RFC5 -3162 4211
RFFL 411 1095
RGCC -4492 7232
RHEB 2587 6311
RHNO1 -2121 511
RICTOR -2640 2833
RING1 -1660 1003
RMI2 120 -1676
RNF111 1846 6049
RNF2 368 2513
RNF34 -780 1414
RNGTT 1072 14
RNMT -3141 6871
RNPS1 -3275 537
RORA -4196 6933
RPA1 -4364 6282
RPA3 -3830 2526
RPAP2 -1235 2798
RPRD1A 169 3830
RPRD2 -1242 4610
RPS27A -4269 2589
RPTOR -1341 5596
RRAGA 3206 6806
RRAGC 1583 5284
RRAGD 3274 -1656
RRM2 -721 4440
RRM2B 1285 1208
RRN3 -4330 2204
RTF1 1637 6570
RUNX1 4116 193
RUNX2 -4238 2447
RUNX3 -2362 6760
RYBP 2810 6819
SAP130 3119 5020
SAP18 1226 5887
SAP30 3993 1163
SAP30BP 171 5733
SAP30L 2256 5024
SATB2 3691 2932
SCMH1 -4153 95
SCO1 -2632 6273
SCO2 -1799 3284
SEC13 2199 6211
SEH1L -4328 3577
SESN1 -2060 4661
SESN2 3795 -84
SESN3 -1577 4705
SETD1A -2691 -815
SETD1B 1550 2093
SETD9 -1644 -411
SFN 270 -1779
SGK1 -2329 -1194
SIN3A -2967 3819
SIN3B -18 -419
SIRT1 -2768 6547
SIRT3 -1518 661
SKI -2429 2897
SKIL 2470 3946
SKP1 -1442 2680
SKP2 -1179 1707
SLBP 84 428
SLC2A3 4329 -1211
SLC38A9 1908 6117
SLU7 1076 1094
SMAD1 4645 206
SMAD2 2413 1865
SMAD3 -3734 -363
SMAD4 -2091 -1925
SMAD6 4249 5259
SMAD7 100 1420
SMARCA2 846 6063
SMARCA4 3223 6792
SMARCA5 -1485 -466
SMARCB1 -1266 6568
SMARCC1 -1376 2301
SMARCC2 1111 5960
SMARCD1 -2664 -130
SMARCD2 3138 3941
SMARCE1 -583 3183
SMURF1 1871 6934
SMURF2 -2759 3523
SMYD2 -3605 6312
SNAPC1 -470 2196
SNAPC2 2909 -575
SNAPC3 796 685
SNAPC4 -402 5250
SNAPC5 -667 4907
SNRPB -1019 4948
SNRPD3 -2366 -377
SNRPE -2958 3730
SNRPG 445 3411
SNW1 1711 2517
SOCS3 4419 6492
SOCS4 -1786 4739
SOD2 2190 6134
SP1 3396 4865
SPI1 4565 -1985
SRC -2136 -1476
SREBF1 387 2475
SRRM1 -477 3813
SRRT -2680 1308
SRSF11 -3976 -51
SRSF2 -3314 212
SRSF3 -1955 -1225
SRSF4 2720 6867
SRSF7 -3519 618
SRSF9 3299 745
SSB -2580 4891
SSRP1 -4110 770
SSU72 1509 2386
STAT1 -4254 4970
STK11 -574 750
STUB1 -602 2320
SUDS3 1113 1432
SUMO1 2118 3368
SUPT16H -4222 4839
SUPT4H1 1728 5918
SUPT5H -1710 2020
SUPT6H 1841 1349
SURF1 1095 -170
SYMPK -195 2886
TACO1 -112 -240
TAF10 3677 5288
TAF11 586 882
TAF12 3434 3413
TAF13 3598 3627
TAF15 -1524 4237
TAF1A -3715 4832
TAF1B -324 -322
TAF1C -640 1350
TAF1D -3439 5423
TAF2 182 292
TAF3 -1177 1363
TAF4 78 554
TAF4B -3905 4706
TAF5 -2526 3430
TAF6 -417 6843
TAF7 376 455
TAF8 2604 5526
TAF9 -1869 4396
TARBP2 -1934 3789
TBL1XR1 1687 2633
TCEA1 -1750 4154
TCF12 501 -542
TCF3 -2863 -374
TCF7 -4620 6951
TCF7L2 4387 1660
TDG 2035 -1070
TDRKH -3489 817
TET1 -3502 5294
TET3 3668 7238
TFAM -3717 1500
TFAP2E -710 -857
TFDP1 3248 2953
TFDP2 -3389 -1478
TGFA 4325 4632
TGFB1 2241 3769
TGIF1 -2962 -390
TGIF2 -4030 -1905
THOC1 -3593 6023
THOC5 4156 3364
THOC7 1231 5594
THRA -1356 761
TIGAR 2481 5175
TMEM219 158 1282
TNFRSF10A -1831 2821
TNFRSF10B 2678 -670
TNFRSF10D 2388 3086
TNKS1BP1 -3529 3401
TNRC6A -777 5197
TNRC6B -251 7059
TOP3A 3871 3073
TOPBP1 -338 3545
TP53 -4050 2709
TP53BP2 3385 -1534
TP53I3 4651 2407
TP53INP1 1949 3584
TP53RK -3679 2847
TPR -1675 4616
TPX2 2062 261
TRIAP1 -2165 6160
TRIM28 -3382 3596
TRIM33 21 6680
TSC1 -336 4696
TSC2 775 3951
TSN -1074 4855
TSNAX 1133 7136
TTC5 -2227 3420
TTF1 -260 3536
TWISTNB -3583 74
TXN 3643 -1735
TXNIP -1224 6154
TXNRD1 3917 -1402
U2AF1 2605 1030
U2AF1L4 -517 5616
U2AF2 -844 6132
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
UBE2C 1221 4535
UBE2D1 3774 2741
UBE2D3 3445 3005
UBE2E1 68 2408
UBE2I 14 5796
UBE2S 1470 -706
UBTF -3869 1855
UHRF1 958 6173
USP7 2187 3259
VDR 4632 3980
VEGFA 2025 87
WDR33 -1054 3468
WDR5 -824 1100
WDR61 -718 1522
WRN -4354 6296
WWOX -3828 4712
WWP1 -4551 479
XPO5 -3626 5412
YAF2 -541 -1487
YEATS4 -2911 4457
YES1 -1029 5198
YWHAB 2512 2152
YWHAE 3796 1288
YWHAG 4225 1919
YWHAH 4276 -1276
YWHAQ -1174 3225
YWHAZ 2353 4294
YY1 -1642 1468
ZC3H8 -4503 1561
ZFHX3 2442 6885
ZFP1 -3811 2171
ZFP14 -2437 5520
ZFP28 -4224 2617
ZFP30 -2814 37
ZFP37 -3535 5350
ZFP90 -2728 4023
ZFPM1 -1229 6831
ZIK1 -4490 1200
ZKSCAN1 1289 3832
ZKSCAN3 -562 -582
ZKSCAN4 39 1247
ZKSCAN5 2836 732
ZKSCAN8 -2980 -1984
ZNF10 -3397 5984
ZNF101 -2712 5649
ZNF136 -4460 1381
ZNF138 -4242 2889
ZNF14 -4303 2143
ZNF140 -3049 5707
ZNF141 -3527 5326
ZNF143 2383 5194
ZNF155 -638 3581
ZNF160 -874 -597
ZNF169 -1606 -198
ZNF17 -3289 4405
ZNF175 -2931 3286
ZNF18 1827 -140
ZNF180 -3554 2630
ZNF184 -3398 2160
ZNF189 609 1728
ZNF19 -1701 -906
ZNF2 -2246 2263
ZNF20 2070 4018
ZNF200 375 5252
ZNF202 -4358 -391
ZNF211 -3878 5488
ZNF212 -3750 1817
ZNF213 3572 2868
ZNF215 1064 -1505
ZNF221 -1236 -1001
ZNF222 -39 3892
ZNF223 -2709 880
ZNF224 -2756 2025
ZNF226 -3419 3324
ZNF227 -2448 808
ZNF23 -3613 -45
ZNF233 -1119 -1823
ZNF234 -2727 6392
ZNF235 -3859 -827
ZNF248 -4256 3065
ZNF25 1150 2002
ZNF250 -2192 720
ZNF253 -3781 5994
ZNF257 -2956 6731
ZNF26 -2554 335
ZNF264 -699 -325
ZNF268 -1788 717
ZNF274 -3242 -269
ZNF282 3235 820
ZNF286A -4356 5052
ZNF287 -4463 867
ZNF3 -3308 3563
ZNF302 -4459 2690
ZNF324 -2314 4648
ZNF324B -1222 3238
ZNF331 -4059 -492
ZNF333 2486 3278
ZNF337 -4361 956
ZNF33A -1982 656
ZNF33B -4604 4399
ZNF34 109 486
ZNF343 -3371 837
ZNF354A 1492 4628
ZNF354C -4283 439
ZNF382 -2356 6294
ZNF394 955 1889
ZNF398 -133 4259
ZNF417 -2874 6888
ZNF418 -2505 -1273
ZNF419 -4071 -1243
ZNF420 -4580 1738
ZNF425 -851 6237
ZNF426 -354 -356
ZNF43 -3728 5317
ZNF430 -3024 -1128
ZNF431 -3773 5327
ZNF432 -3590 4336
ZNF436 -1986 3369
ZNF440 -1763 6886
ZNF443 -188 174
ZNF445 3045 322
ZNF446 -3270 676
ZNF461 -3794 2022
ZNF468 1958 -1501
ZNF470 -3076 5113
ZNF480 -3345 3110
ZNF483 -3330 3488
ZNF484 -2141 -1057
ZNF490 1511 4420
ZNF492 -1542 2700
ZNF496 -2386 2746
ZNF500 -2431 2619
ZNF506 -2878 1927
ZNF517 -4213 6892
ZNF528 -3545 -1161
ZNF529 -3842 6135
ZNF530 -4543 5650
ZNF540 -4173 1989
ZNF546 -1626 4961
ZNF547 -1108 5028
ZNF549 -4538 3573
ZNF550 -3752 -650
ZNF552 2601 3735
ZNF554 -3600 3039
ZNF559 -3597 3388
ZNF561 -1009 3917
ZNF563 -4027 6436
ZNF564 -1424 5905
ZNF566 -4451 2789
ZNF567 -4219 4984
ZNF568 -3858 -177
ZNF569 -2545 1805
ZNF570 -3427 -836
ZNF571 -3704 6813
ZNF573 -2788 1491
ZNF582 -3769 2353
ZNF583 -3911 230
ZNF584 -2372 -1262
ZNF585A -1785 6258
ZNF585B -2287 3175
ZNF587 524 4918
ZNF589 -1083 5516
ZNF596 -2311 -1900
ZNF597 -3281 3305
ZNF600 -2317 -1258
ZNF605 -2130 -1067
ZNF606 -3249 3490
ZNF610 -1519 4541
ZNF611 1000 2480
ZNF613 1473 6560
ZNF614 -3266 6322
ZNF615 -1246 2660
ZNF619 267 -1439
ZNF620 -1833 -1051
ZNF621 -1759 1639
ZNF624 -723 19
ZNF627 -69 268
ZNF641 244 -1172
ZNF655 -596 5619
ZNF664 -3731 1404
ZNF665 -936 3845
ZNF668 823 -545
ZNF670 -1867 -578
ZNF671 -3845 1792
ZNF677 -2918 2486
ZNF678 -3449 3886
ZNF681 -4297 6567
ZNF684 -485 3999
ZNF688 -1209 1886
ZNF689 -1218 2936
ZNF691 -972 2013
ZNF692 -2679 1658
ZNF696 -4038 -563
ZNF70 -2142 399
ZNF700 -466 1456
ZNF701 853 2213
ZNF703 -1281 -229
ZNF706 -2440 -1329
ZNF707 -2825 977
ZNF708 -3198 1382
ZNF709 -2847 6111
ZNF710 4091 -1778
ZNF713 -820 -703
ZNF714 -1027 5273
ZNF717 -1299 566
ZNF736 -3358 6094
ZNF737 -3508 2021
ZNF74 -4171 4957
ZNF740 -3820 5117
ZNF746 3700 512
ZNF747 357 6503
ZNF749 -3932 -1833
ZNF75A -3586 7086
ZNF761 -3556 -599
ZNF764 -1286 6186
ZNF77 -1625 179
ZNF771 -2937 547
ZNF772 -2602 5398
ZNF774 2229 4930
ZNF775 1946 2200
ZNF776 -932 5899
ZNF777 -2233 4582
ZNF778 653 5260
ZNF782 -2599 -705
ZNF785 -2215 1396
ZNF786 -2204 -224
ZNF79 195 2360
ZNF790 -2677 1406
ZNF791 -834 6431
ZNF792 -3169 332
ZNF793 -3584 1232
ZNF799 -2820 3846
ZNF839 791 -1105
ZNF92 -2472 3537
ZNRD1 -1521 308
ZSCAN25 -3373 7058



Diseases of signal transduction by growth factor receptors and second messengers

Diseases of signal transduction by growth factor receptors and second messengers
metric value
setSize 259
pMANOVA 7.74e-11
p.adjustMANOVA 2.41e-09
s.dist 0.243
s.RNA 0.234
s.meth 0.0655
p.RNA 1.27e-10
p.meth 0.0718




Top 20 genes
Gene RNA meth
MAPK1 4560 6099
KSR1 3863 7147
GRB2 4420 6241
APH1B 3617 6785
RAC1 4404 5541
IRS2 3955 6152
SPRED2 4200 5462
VAV1 3798 5834
CUX1 4609 4795
PSMA7 3130 6903
RAF1 3220 6573
PSMD4 3947 5314
PSEN1 4223 4955
RAP1A 3123 6569
BIN2 3741 5390
TGFA 4325 4632
LRRFIP1 3688 5297
BCL2L11 3447 5664
FOXO3 3816 5023
STAT3 3772 4995

Click HERE to show all gene set members

All member genes
RNA meth
ADAM10 4095 2760
ADAM17 4436 4155
AGGF1 2281 889
AGK -3991 492
AGTRAP 4281 -1858
AKAP9 -931 1042
AKT1 1891 1109
AKT1S1 2817 1894
AKT2 781 5431
AP3B1 3362 3782
APBB1IP 4238 3821
APC 1393 1992
APH1A 1304 -119
APH1B 3617 6785
ARRB1 1885 -1278
ARRB2 4237 2913
ATG7 2429 3847
AXIN1 -1579 -858
BAD 2906 4374
BAG4 3754 828
BCL2L11 3447 5664
BCR 659 -1913
BIN2 3741 5390
BRAF 1030 -1526
BRAP 2450 -135
CALM1 263 4502
CAMK2D -4530 -529
CAMK2G -152 6718
CASP9 4537 3202
CBL 3732 1012
CCNC -2266 4188
CDK8 795 5795
CDKN1A 2283 2427
CDKN1B -1212 3367
CHUK 3354 1111
CLCN6 1258 1827
CNTRL -776 -1527
CPSF6 -2877 -1024
CREB1 -1458 1422
CREBBP 2340 892
CSK 3371 4890
CSNK1A1 3363 4452
CTBP1 800 6471
CTNNB1 3473 5070
CUL1 -4005 -1192
CUX1 4609 4795
DERL2 212 -1578
DUSP10 174 4700
DUSP16 -3228 28
DUSP6 -702 -1943
DUSP7 -732 722
EP300 3478 4901
ERBB2 -2008 4160
ERLEC1 1033 1240
ERLIN2 4490 786
ESR2 -3413 4784
ETV6 3020 -772
FBXW7 -1004 6667
FGF9 -3638 997
FGFR1OP -2331 1933
FGFR1OP2 1078 2788
FIP1L1 -540 3099
FKBP1A 3631 1814
FOXO1 -4458 3034
FOXO3 3816 5023
FRS2 -959 -882
FXR1 -99 5875
FYN -1686 2793
FZD5 4639 2664
FZD6 -3565 735
FZD8 -2070 2234
GAB2 4007 2390
GOLGA4 -644 775
GRB2 4420 6241
GSK3A 3876 2534
GSK3B 2685 4908
GTF2F1 2455 558
GTF2F2 2495 5307
HBEGF 646 -1007
HDAC1 -207 3287
HDAC10 413 4924
HDAC11 1672 6084
HDAC2 -1260 5864
HDAC3 1734 7116
HDAC4 4304 887
HDAC5 903 3068
HDAC7 1275 -487
HHAT -2583 459
HRAS -2340 -823
HSP90AA1 -729 6210
IQGAP1 4024 587
IRS1 -2666 4308
IRS2 3955 6152
JAK2 1159 6489
KANK1 -3772 4095
KAT2A -4179 1343
KAT2B -105 4028
KRAS 2245 3139
KSR1 3863 7147
LCK -4408 7246
LMNA 1699 -1377
LRP5 -1398 -123
LRP6 -3051 1600
LRRFIP1 3688 5297
MAML1 2981 1442
MAML2 -3215 4627
MAML3 4174 3460
MAP2K1 4239 1533
MAP2K2 2556 6410
MAP3K11 4002 1270
MAPK1 4560 6099
MAPK3 3461 1978
MAPKAP1 1834 5908
MARK3 4168 3805
MDM2 2338 2095
MIB1 -2050 3187
MLST8 -394 2258
MPRIP -4437 2328
MTOR -141 3900
MYO18A 2148 -1785
NCBP1 -1093 5859
NCBP2 -4299 4777
NCOR1 3183 -530
NCOR2 4562 -1609
NCSTN 4654 1224
NF1 2485 -328
NOTCH1 2941 6291
NR4A1 -431 1085
OS9 4487 -313
PAPSS1 4245 2272
PDPK1 3218 346
PEBP1 -4410 4325
PHB -2116 4542
PIK3AP1 4435 1373
PIK3CA 946 1470
PIK3CD 2671 6109
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R3 995 3645
PLCG1 -4367 958
POLR2A 2412 4046
POLR2B -903 5563
POLR2C -520 6356
POLR2D -2238 -614
POLR2E 2119 3712
POLR2F 1375 509
POLR2G 1618 1604
POLR2H -2765 6299
POLR2I -1337 5657
POLR2K -1277 3853
PPP1CB 2691 -340
PPP1CC 1107 5379
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5A 3674 -230
PPP2R5B 3304 -286
PPP2R5C -1671 7074
PPP2R5D 2123 3470
PPP2R5E -4 1402
PRR5 -2935 -347
PSEN1 4223 4955
PSEN2 -2281 -162
PSENEN 2445 4980
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PTEN 3783 4815
PTPN11 2499 5062
PTPN12 3373 -982
QKI 3485 2796
RAC1 4404 5541
RAC2 2815 4577
RAF1 3220 6573
RAP1A 3123 6569
RAP1B 3135 5968
RBPJ 4163 1033
RBX1 2032 5883
RHOG 4253 3664
RICTOR -2640 2833
RPS27A -4269 2589
RPS6KB2 502 4805
SEL1L 3003 4058
SHC1 3684 3205
SHOC2 2762 34
SKP1 -1442 2680
SMAD2 2413 1865
SMAD3 -3734 -363
SMAD4 -2091 -1925
SND1 1332 2977
SNW1 1711 2517
SOS1 -1564 -1986
SPRED1 1438 6065
SPRED2 4200 5462
SPRED3 382 5938
SRC -2136 -1476
STAT1 -4254 4970
STAT3 3772 4995
STAT5A 2951 -1545
STAT5B 2832 1495
STRN 2310 6485
SYVN1 813 -846
TBL1XR1 1687 2633
TCF7L2 4387 1660
TGFA 4325 4632
TGFB1 2241 3769
TGFBR1 1602 -1264
TGFBR2 1403 2870
TLN1 4172 -983
TNKS -609 4477
TNKS2 924 2960
TRIM24 496 -938
TSC2 775 3951
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
VAV1 3798 5834
VCL 2594 3614
VCP 3034 1908
WDR48 -3187 2818
YES1 -1029 5198
YWHAB 2512 2152
ZC3HAV1 -3264 3768
ZFYVE9 -4371 3529
ZMYM2 1546 4446



Signaling by WNT

Signaling by WNT
metric value
setSize 174
pMANOVA 1.15e-09
p.adjustMANOVA 3.49e-08
s.dist 0.273
s.RNA 0.192
s.meth 0.194
p.RNA 1.43e-05
p.meth 1.14e-05




Top 20 genes
Gene RNA meth
CLTC 4203 7259
GNG5 4379 6512
RAC1 4404 5541
AGO1 3338 7140
FRAT1 4121 5692
SMARCA4 3223 6792
PSMA7 3130 6903
PSMD4 3947 5314
TLE4 3995 5138
AP2S1 3281 6039
PSMA6 2659 6678
CTNNB1 3473 5070
PSME3 3326 5232
PRKCB 3491 4964
FRAT2 4118 4158
EP300 3478 4901
KMT2D 2624 6495
CSNK2A2 2821 5736
PSMB6 2767 5819
RHOA 3965 4033

Click HERE to show all gene set members

All member genes
RNA meth
AGO1 3338 7140
AGO2 1363 7196
AGO3 384 3465
AKT1 1891 1109
AKT2 781 5431
AP2A1 4623 -316
AP2M1 3567 3723
AP2S1 3281 6039
APC 1393 1992
ARRB2 4237 2913
ASH2L 3680 3075
AXIN1 -1579 -858
AXIN2 -3958 152
BCL9 -1247 4909
BTRC -1864 -923
CALM1 263 4502
CAV1 249 4592
CBY1 -3791 3274
CCDC88C -2271 6961
CDC73 2258 5719
CHD8 2508 -916
CLTA 3106 -546
CLTB 3122 -918
CLTC 4203 7259
CREBBP 2340 892
CSNK1A1 3363 4452
CSNK1E -2944 3000
CSNK1G2 873 2563
CSNK2A2 2821 5736
CSNK2B 1983 4743
CTBP1 800 6471
CTNNB1 3473 5070
CTNNBIP1 2756 1589
CUL1 -4005 -1192
CUL3 2435 -873
DAAM1 334 6127
DACT1 69 6080
DVL1 -2283 6368
DVL2 -3069 4884
DVL3 3827 161
EP300 3478 4901
FRAT1 4121 5692
FRAT2 4118 4158
FZD2 1735 2618
FZD3 -2857 6062
FZD5 4639 2664
FZD6 -3565 735
FZD7 -2336 2145
FZD8 -2070 2234
GNB1 4261 2799
GNB2 4032 1879
GNB4 3205 1335
GNB5 -1662 6256
GNG2 1513 6500
GNG3 1124 7142
GNG4 858 6856
GNG5 4379 6512
GNG7 -3064 -499
GNGT2 859 7120
GSK3B 2685 4908
HDAC1 -207 3287
ITPR1 -1851 1789
ITPR2 2474 -44
ITPR3 -2973 2189
KAT5 1382 1952
KLHL12 4083 3615
KMT2D 2624 6495
KRAS 2245 3139
LEO1 197 4252
LRP5 -1398 -123
LRP6 -3051 1600
MAP3K7 1566 -147
MEN1 -2694 1903
MOV10 -2729 -1882
NFATC1 -2143 6947
NLK 2043 -208
PARD6A -2303 4619
PDE6B -4014 1268
PFN1 3195 3814
PLCB2 2360 903
PLCB3 4578 -1268
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5A 3674 -230
PPP2R5B 3304 -286
PPP2R5C -1671 7074
PPP2R5D 2123 3470
PPP2R5E -4 1402
PPP3CA 1951 5980
PPP3CB 2717 4044
PPP3R1 2516 2945
PRKCA -1148 6894
PRKCB 3491 4964
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PYGO2 -4034 6530
RAC1 4404 5541
RAC2 2815 4577
RAC3 -586 827
RBBP5 -425 2829
RBX1 2032 5883
RHOA 3965 4033
RNF146 4444 1611
RPS27A -4269 2589
RUNX3 -2362 6760
RUVBL1 -3041 4751
RYK -4311 4958
SCRIB 428 -1418
SKP1 -1442 2680
SMARCA4 3223 6792
SMURF1 1871 6934
SMURF2 -2759 3523
SOX4 2798 4439
TCF7 -4620 6951
TCF7L2 4387 1660
TERT -1961 7281
TLE2 -4558 1969
TLE3 4495 3113
TLE4 3995 5138
TMED5 2919 1678
TNKS -609 4477
TNKS2 924 2960
TNRC6A -777 5197
TNRC6B -251 7059
TRRAP -967 6328
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
USP34 -210 1573
USP8 2773 4109
VPS26A 2851 4070
VPS29 1937 688
VPS35 2985 -1447
WNT1 -2641 2325
WNT2B 1017 3566
XPO1 -925 6847
YWHAZ 2353 4294
ZNRF3 -2412 3859



tRNA processing

tRNA processing
metric value
setSize 93
pMANOVA 1.23e-09
p.adjustMANOVA 3.62e-08
s.dist 0.39
s.RNA -0.381
s.meth 0.0824
p.RNA 2.28e-10
p.meth 0.171




Top 20 genes
Gene RNA meth
NUP88 -4449 7084
NDC1 -4582 6482
QTRT1 -4259 5789
NUP43 -3608 6346
ALKBH8 -4523 5003
PUS7 -4154 5387
LCMT2 -3476 6264
NUP107 -3437 6301
TRMT61B -3983 5388
POP5 -3578 5989
RPP25 -3481 5745
METTL1 -4462 4406
PUS1 -3552 4830
RPP38 -3570 4780
CTU2 -2353 7026
TRMU -2518 6387
SEH1L -4328 3577
TRIT1 -1914 6755
ADAT2 -3505 3497
TSEN2 -3696 3306

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1807 1467
ADAT1 -530 5559
ADAT2 -3505 3497
ADAT3 1444 6334
ALKBH8 -4523 5003
C2orf49 -2260 2636
CDKAL1 -2241 4217
CLP1 2017 2378
CPSF1 -446 1083
CPSF4 -1522 1770
CTU1 1570 4162
CTU2 -2353 7026
DDX1 -2550 2193
DUS2 685 710
ELAC2 -1929 275
FAM98B -2397 2205
GTPBP3 -3122 1640
LCMT2 -3476 6264
METTL1 -4462 4406
MTO1 -2876 396
NDC1 -4582 6482
NSUN2 -489 2230
NSUN6 -1292 2767
NUP107 -3437 6301
NUP133 -2181 935
NUP153 -709 4344
NUP155 -3052 3043
NUP160 -3890 1293
NUP188 -3651 2922
NUP205 -3468 1670
NUP210 -1977 690
NUP214 3636 4369
NUP35 -4479 -557
NUP37 126 3398
NUP43 -3608 6346
NUP50 1354 6706
NUP54 -3105 831
NUP62 -1130 4609
NUP85 -1192 4518
NUP88 -4449 7084
NUP93 -2021 2006
NUP98 1358 -747
POM121 -1045 4681
POM121C -663 2061
POP1 -1854 3613
POP4 395 1072
POP5 -3578 5989
POP7 43 3070
PUS1 -3552 4830
PUS3 287 965
PUS7 -4154 5387
QTRT1 -4259 5789
RAE1 1241 2634
RAN -3182 1483
RANBP2 -757 5165
RPP14 118 2236
RPP21 -2049 2599
RPP25 -3481 5745
RPP30 -3480 668
RPP38 -3570 4780
RPP40 -4564 570
RPPH1 4228 5012
RTCB 713 -1473
SEC13 2199 6211
SEH1L -4328 3577
THADA -2866 4244
THG1L -2457 2917
TP53RK -3679 2847
TPR -1675 4616
TPRKB -3210 3473
TRDMT1 -519 -401
TRIT1 -1914 6755
TRMT1 -3114 -744
TRMT10A 2348 1313
TRMT11 -4370 2032
TRMT112 -966 1929
TRMT12 -807 -1653
TRMT44 -2698 -1516
TRMT6 3319 3940
TRMT61A -3119 3423
TRMT61B -3983 5388
TRMU -2518 6387
TRNT1 -2354 4675
TSEN15 -3334 502
TSEN2 -3696 3306
TSEN34 3376 1820
TSEN54 -3374 591
TYW1 -4060 2393
TYW3 -4145 985
TYW5 548 3607
URM1 -458 3783
XPOT -1979 2981
ZBTB8OS 2016 266



rRNA modification in the nucleus and cytosol

rRNA modification in the nucleus and cytosol
metric value
setSize 47
pMANOVA 1.56e-09
p.adjustMANOVA 4.47e-08
s.dist 0.545
s.RNA -0.531
s.meth 0.123
p.RNA 3.19e-10
p.meth 0.144




Top 20 genes
Gene RNA meth
RPS2 -3934 6975
NOP2 -3984 6403
SNU13 -3338 7054
WDR43 -4245 5510
UTP15 -4147 5063
WDR75 -4506 4614
MPHOSPH10 -3582 5401
RCL1 -2883 6343
HEATR1 -3399 5201
UTP20 -3435 5085
IMP3 -3090 5542
PNO1 -2601 6496
NOL6 -3657 4557
RPS7 -3610 4408
WDR36 -2277 6601
UTP6 -3440 3932
IMP4 -3470 3786
NHP2 -2502 4827
NOL11 -4544 2571
NOP14 -4344 2209

Click HERE to show all gene set members

All member genes
RNA meth
BMS1 -4345 -1755
DCAF13 -2402 862
DDX47 -4298 -50
DDX49 1396 5582
DDX52 927 -204
DHX37 -2117 4195
FBL -4453 -43
FCF1 1012 6763
GAR1 -2663 879
HEATR1 -3399 5201
IMP3 -3090 5542
IMP4 -3470 3786
KRR1 -3409 -1952
MPHOSPH10 -3582 5401
NHP2 -2502 4827
NOC4L 535 -799
NOL11 -4544 2571
NOL6 -3657 4557
NOP10 4046 2081
NOP14 -4344 2209
NOP2 -3984 6403
NOP56 -4355 996
NOP58 -4534 1333
PDCD11 -2672 3455
PNO1 -2601 6496
PWP2 -202 5076
RCL1 -2883 6343
RPS2 -3934 6975
RPS6 -4216 361
RPS7 -3610 4408
RPS9 1181 627
RRP7A -1380 1582
RRP9 -3749 653
SNU13 -3338 7054
TBL3 -235 5418
THUMPD1 -4426 -871
TRMT112 -966 1929
TSR3 1137 6370
UTP15 -4147 5063
UTP18 1330 3357
UTP20 -3435 5085
UTP3 -1599 3926
UTP6 -3440 3932
WDR3 -3009 -1387
WDR36 -2277 6601
WDR43 -4245 5510
WDR75 -4506 4614



Signaling by NOTCH

Signaling by NOTCH
metric value
setSize 129
pMANOVA 1.84e-09
p.adjustMANOVA 5.16e-08
s.dist 0.313
s.RNA 0.258
s.meth 0.178
p.RNA 4.77e-07
p.meth 0.000518




Top 20 genes
Gene RNA meth
FURIN 4429 7181
APH1B 3617 6785
AGO1 3338 7140
NUMB 4622 5039
B4GALT1 3113 7043
PSMA7 3130 6903
PSMD4 3947 5314
PSEN1 4223 4955
TLE4 3995 5138
TACC3 3402 5485
NOTCH4 3739 4962
NOTCH1 2941 6291
ADAM17 4436 4155
PSMA6 2659 6678
SIRT6 2625 6645
PSME3 3326 5232
EP300 3478 4901
PSMB6 2767 5819
DTX4 3109 5144
MAML3 4174 3460

Click HERE to show all gene set members

All member genes
RNA meth
ACTA2 456 4718
ADAM10 4095 2760
ADAM17 4436 4155
AGO1 3338 7140
AGO2 1363 7196
AGO3 384 3465
AKT1 1891 1109
APH1A 1304 -119
APH1B 3617 6785
ARRB1 1885 -1278
ARRB2 4237 2913
ATP2A1 -104 5724
ATP2A2 3880 -1550
ATP2A3 577 1877
B4GALT1 3113 7043
CCNC -2266 4188
CCND1 -2034 1006
CDK8 795 5795
CREB1 -1458 1422
CREBBP 2340 892
CUL1 -4005 -1192
DLGAP5 1638 -1160
DTX4 3109 5144
E2F1 2365 3145
E2F3 3590 2135
EP300 3478 4901
FBXW7 -1004 6667
FURIN 4429 7181
HDAC1 -207 3287
HDAC10 413 4924
HDAC11 1672 6084
HDAC2 -1260 5864
HDAC3 1734 7116
HDAC4 4304 887
HDAC5 903 3068
HDAC7 1275 -487
HIF1A 3440 2448
IKZF1 -991 5424
ITCH 2362 4854
JUN -400 1283
KAT2A -4179 1343
KAT2B -105 4028
LFNG 154 6685
MAML1 2981 1442
MAML2 -3215 4627
MAML3 4174 3460
MFNG -3156 6333
MIB1 -2050 3187
MOV10 -2729 -1882
NBEA -3497 7003
NCOR1 3183 -530
NCOR2 4562 -1609
NCSTN 4654 1224
NOTCH1 2941 6291
NOTCH4 3739 4962
NUMB 4622 5039
PLXND1 4196 -1845
POFUT1 2930 3622
PRKCI -1890 1662
PSEN1 4223 4955
PSEN2 -2281 -162
PSENEN 2445 4980
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSMF1 2008 7182
RAB6A 3957 3323
RBPJ 4163 1033
RBX1 2032 5883
RPS27A -4269 2589
RUNX1 4116 193
SEL1L 3003 4058
SIRT6 2625 6645
SKP1 -1442 2680
SMAD3 -3734 -363
SNW1 1711 2517
ST3GAL3 -1399 5837
ST3GAL4 3906 -1351
ST3GAL6 1264 6719
STAT1 -4254 4970
TACC3 3402 5485
TBL1XR1 1687 2633
TFDP1 3248 2953
TFDP2 -3389 -1478
TLE2 -4558 1969
TLE3 4495 3113
TLE4 3995 5138
TMED2 2394 5946
TNRC6A -777 5197
TNRC6B -251 7059
TP53 -4050 2709
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
WWP2 4309 2916
YBX1 1836 6425
YWHAZ 2353 4294



Disease

Disease
metric value
setSize 870
pMANOVA 5.73e-09
p.adjustMANOVA 1.56e-07
s.dist 0.122
s.RNA 0.107
s.meth 0.0594
p.RNA 1.88e-07
p.meth 0.00384




Top 20 genes
Gene RNA meth
FURIN 4429 7181
CLTC 4203 7259
GNG5 4379 6512
MYO9B 4114 6777
MAPK1 4560 6099
CRK 4199 6598
KSR1 3863 7147
GRB2 4420 6241
TLR5 4499 5701
AP1B1 4393 5783
ST6GALNAC3 4530 5569
DNAJC3 3890 6472
ELMO2 4026 6110
APH1B 3617 6785
RAC1 4404 5541
IRS2 3955 6152
E2F2 4624 5231
ENTPD1 3310 7219
ACTB 4359 5447
ADM 4640 5105

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1807 1467
ABCA1 2550 -82
ABCB6 -1591 -698
ABCD4 -2230 4719
ABI1 3644 3253
ABI2 -3635 -206
ABL1 1975 2469
ACACA 3369 1077
ACTB 4359 5447
ACTG1 3825 1603
ACTR2 3672 3844
ACTR3 3554 5952
ACY1 -2389 1746
ADAM10 4095 2760
ADAM17 4436 4155
ADAMTS10 -2542 -1433
ADAMTS13 -877 -1294
ADAMTS17 -2697 -67
ADAMTS6 -538 -624
ADAMTSL4 4434 1776
ADAMTSL5 -3415 -1286
ADCY4 3163 -1006
ADCY7 1818 -981
ADCY9 -666 5439
ADM 4640 5105
ADORA2A 616 7186
ADRB2 -1555 2808
AGGF1 2281 889
AGK -3991 492
AGRN -2908 2227
AGTRAP 4281 -1858
AHCY -854 5996
AHCYL1 2934 2692
AKAP9 -931 1042
AKT1 1891 1109
AKT1S1 2817 1894
AKT2 781 5431
ALG11 -994 5298
ALG12 620 1540
ALG14 1867 1973
ALG2 -1025 6978
ALG3 -1746 3191
ALG6 -286 2858
ALG8 -1932 1673
ALG9 -3131 2495
ANAPC1 -4482 2990
ANAPC10 -418 -1326
ANAPC11 1271 3188
ANAPC15 3233 6483
ANAPC16 -2423 6729
ANAPC2 -2051 2865
ANAPC4 -1105 -687
ANAPC5 -2994 5213
ANAPC7 175 1873
ANTXR2 2216 1887
AP1B1 4393 5783
AP1G1 2519 2214
AP1M1 3701 1777
AP1S3 -992 1942
AP2A1 4623 -316
AP2M1 3567 3723
AP2S1 3281 6039
AP3B1 3362 3782
APBB1IP 4238 3821
APC 1393 1992
APH1A 1304 -119
APH1B 3617 6785
APP 2952 6623
ARF1 4345 -1821
ARPC1B 4422 1709
ARPC2 3659 2292
ARPC3 3630 3208
ARPC5 4209 2611
ARRB1 1885 -1278
ARRB2 4237 2913
ARSB 4014 -1528
ATG7 2429 3847
ATP1A1 2074 4101
ATP6V1H 3287 2559
AXIN1 -1579 -858
B2M -2207 -9
B3GALT6 -1911 7224
B3GAT3 -531 3020
B4GALT1 3113 7043
B4GALT7 -2263 4233
B4GAT1 -2943 -1493
BAD 2906 4374
BAG4 3754 828
BAIAP2 -1012 2757
BANF1 -1978 4202
BCL2L11 3447 5664
BCR 659 -1913
BECN1 2552 4915
BIN2 3741 5390
BRAF 1030 -1526
BRAP 2450 -135
BRD4 3851 -1062
BRK1 1195 3071
BSG 4125 205
BTD -4131 -811
BTRC -1864 -923
C1GALT1 -635 2851
C1QBP -3634 5787
C3AR1 4610 -1596
CALM1 263 4502
CALR 2667 5714
CAMK2D -4530 -529
CAMK2G -152 6718
CAMK4 -4622 2759
CANX 1895 3479
CAPN1 4333 1819
CAPN2 2058 453
CAPNS1 4234 5570
CASP1 1192 7031
CASP9 4537 3202
CAST 2999 2787
CBL 3732 1012
CBX1 450 1944
CCNC -2266 4188
CCND1 -2034 1006
CCND2 -4129 -1567
CCND3 4303 4156
CCNE1 -2341 5956
CCNE2 1467 5659
CCNH 645 1260
CCNK 2948 6593
CCNT1 -1783 1761
CD247 -3684 6036
CD320 -2625 5735
CD4 -2816 909
CDC16 -1889 3340
CDC23 -3699 1597
CDC25A 79 3280
CDC25B -4470 6646
CDC25C 1516 5507
CDC42 3449 856
CDK2 -1525 2965
CDK4 -4099 4919
CDK5 4361 3491
CDK5R1 202 7124
CDK6 -2288 562
CDK7 2068 4034
CDK8 795 5795
CDK9 1688 3144
CDKN1A 2283 2427
CDKN1B -1212 3367
CDKN2A -149 3478
CEBPD 4308 -907
CHMP1A 3013 2231
CHMP2A 4044 5362
CHMP2B 1863 1684
CHMP3 3628 3694
CHMP4A 1622 4138
CHMP4B 4150 5512
CHMP5 4056 4370
CHMP6 2880 2702
CHMP7 -4236 6064
CHST14 2295 -38
CHSY1 3341 -1145
CHUK 3354 1111
CLCN6 1258 1827
CLTA 3106 -546
CLTC 4203 7259
CNTRL -776 -1527
COMT 3348 -1096
CORO1A 2202 6642
CPSF4 -1522 1770
CPSF6 -2877 -1024
CRBN -2738 2140
CREB1 -1458 1422
CREBBP 2340 892
CRK 4199 6598
CSK 3371 4890
CSNK1A1 3363 4452
CTBP1 800 6471
CTDP1 3594 1002
CTNNB1 3473 5070
CTNND1 -33 -1709
CTSA 4474 2720
CTSL 4277 3028
CUL1 -4005 -1192
CUL5 -968 344
CUX1 4609 4795
CXCR4 23 -1435
CYBA 4037 2019
CYFIP1 4176 256
CYFIP2 -1121 6159
CYP2R1 -192 3262
CYP2U1 -3234 3858
CYP4F22 1536 5603
DAG1 70 -94
DAXX -1271 1574
DBP -3919 5710
DCXR -177 2344
DDX5 -3032 1804
DERL1 -2237 363
DERL2 212 -1578
DERL3 -2292 1587
DHDDS 3049 383
DNAJC3 3890 6472
DOLK 597 4413
DPAGT1 -886 1961
DPEP2 403 -1338
DPM1 18 5921
DPM2 1067 6197
DPM3 155 5732
DUSP10 174 4700
DUSP16 -3228 28
DUSP6 -702 -1943
DUSP7 -732 722
DUT -3176 1084
DVL1 -2283 6368
DVL2 -3069 4884
DVL3 3827 161
DYNC1H1 416 4434
DYNC1I2 3229 693
DYNC1LI1 3337 3242
DYNC1LI2 2324 -185
DYNLL1 1152 5151
DYNLL2 -1545 -924
E2F1 2365 3145
E2F2 4624 5231
E2F3 3590 2135
EED -2862 3088
EEF2 -2045 4196
EIF2AK2 1466 683
ELL 2401 1501
ELMO1 1982 939
ELMO2 4026 6110
ENO1 3676 -1624
ENTPD1 3310 7219
ENTPD5 -557 451
EP300 3478 4901
EPS15 2111 -516
ERBB2 -2008 4160
ERCC2 1784 1849
ERCC3 -87 1487
ERLEC1 1033 1240
ERLIN1 4317 4339
ERLIN2 4490 786
ESR2 -3413 4784
ETV6 3020 -772
EXT1 4102 962
EXT2 906 5514
EZH2 -920 2695
F12 4633 1484
FAU -1142 6877
FBXW7 -1004 6667
FDX1 -351 3052
FDXR 1212 1657
FEN1 -2301 6950
FGF9 -3638 997
FGFR1OP -2331 1933
FGFR1OP2 1078 2788
FGR 4616 -1075
FIP1L1 -540 3099
FKBP1A 3631 1814
FOXO1 -4458 3034
FOXO3 3816 5023
FRS2 -959 -882
FURIN 4429 7181
FXR1 -99 5875
FYN -1686 2793
FZD5 4639 2664
FZD6 -3565 735
FZD7 -2336 2145
FZD8 -2070 2234
FZR1 564 2326
G6PC3 2662 -1289
GAA 3199 2768
GAB2 4007 2390
GALE 3180 -626
GALK1 4357 -745
GALNS 3231 3670
GALNT12 -3740 -1602
GALNT3 3300 -712
GALT -3641 4007
GANAB 838 4411
GCLC -1714 -1115
GCLM 2749 3701
GFPT1 -1234 -718
GGCX 2712 4622
GGT1 4656 -1937
GIPR -3140 -792
GLB1 4153 1828
GNAI2 4151 3218
GNAI3 3381 2359
GNAS 2180 -60
GNB1 4261 2799
GNB2 4032 1879
GNB4 3205 1335
GNB5 -1662 6256
GNE -1080 2902
GNG2 1513 6500
GNG3 1124 7142
GNG4 858 6856
GNG5 4379 6512
GNG7 -3064 -499
GNGT2 859 7120
GNS 4646 4429
GOLGA2 3731 -1361
GOLGA4 -644 775
GPC2 -3081 7192
GPS2 444 6830
GRB2 4420 6241
GRSF1 27 4316
GSK3A 3876 2534
GSK3B 2685 4908
GSS -642 4119
GTF2A1 204 1479
GTF2A2 1604 286
GTF2B 999 -1154
GTF2E2 2927 4885
GTF2F1 2455 558
GTF2F2 2495 5307
GTF2H3 -3181 5705
GTF2H4 -953 5240
GTF2H5 613 3417
GUSB 4577 2338
GYG1 4447 -231
GYS1 3268 2472
HBEGF 646 -1007
HDAC1 -207 3287
HDAC10 413 4924
HDAC11 1672 6084
HDAC2 -1260 5864
HDAC3 1734 7116
HDAC4 4304 887
HDAC5 903 3068
HDAC7 1275 -487
HEXA -322 5238
HEXB 3333 2906
HGS 2818 4351
HGSNAT 472 3342
HHAT -2583 459
HK1 4482 4612
HLA-A -2315 -1094
HLCS -1322 1122
HMGA1 -2637 2826
HNRNPK 2115 3141
HRAS -2340 -823
HRH2 4642 -109
HSP90AA1 -729 6210
HSP90AB1 -4016 -1226
HSPA1A 3351 -920
HYAL1 2967 -1974
IDH1 4649 3454
IDUA -2506 6735
IKBKB -510 -912
IL1RAP 3464 -1122
IL6R 2774 5066
IMPDH1 4587 2600
IMPDH2 -4613 250
IPO5 -4608 4875
IQGAP1 4024 587
IRS1 -2666 4308
IRS2 3955 6152
ISG15 -2022 6541
ITGA4 -3400 -394
ITPR1 -1851 1789
ITPR2 2474 -44
ITPR3 -2973 2189
JAK1 -2308 -283
JAK2 1159 6489
JUN -400 1283
KANK1 -3772 4095
KAT2A -4179 1343
KAT2B -105 4028
KCNJ11 -1811 -1380
KHK -3190 1476
KPNA1 -443 4423
KPNA2 66 4421
KPNA3 -12 4400
KPNA4 2166 5000
KPNA5 -4039 1847
KPNB1 1964 1140
KRAS 2245 3139
KSR1 3863 7147
LCK -4408 7246
LFNG 154 6685
LIG1 -4416 1086
LIG4 2738 4471
LMBRD1 1625 1757
LMNA 1699 -1377
LMNB1 4349 1051
LRP5 -1398 -123
LRP6 -3051 1600
LRRFIP1 3688 5297
MAML1 2981 1442
MAML2 -3215 4627
MAML3 4174 3460
MAN1B1 -301 6524
MAP2K1 4239 1533
MAP2K2 2556 6410
MAP2K3 4152 2411
MAP2K4 2698 4764
MAP2K6 4437 4792
MAP2K7 -54 1764
MAP3K11 4002 1270
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
MAPK8 -3916 4554
MAPKAP1 1834 5908
MARK3 4168 3805
MCCC1 -2853 5912
MCCC2 -3656 6712
MDM2 2338 2095
MGAT1 3035 3827
MGAT2 1526 4676
MIB1 -2050 3187
MLST8 -394 2258
MMAA -2576 6866
MMAB -2781 1601
MMACHC -2465 -497
MMADHC 2589 5139
MNAT1 -1772 1516
MOGS -1008 5808
MPDU1 3733 377
MPI -4065 1103
MPRIP -4437 2328
MSH2 -3391 5927
MSH3 1630 3032
MSH6 -1252 6464
MTOR -141 3900
MTR -4012 6467
MTRR 1809 4206
MUC1 1680 6715
MUC12 -806 4641
MUC5B 2049 -1745
MUTYH -3551 4906
MVB12A 2841 357
MYD88 4594 1945
MYH9 3463 6146
MYO18A 2148 -1785
MYO9B 4114 6777
NAGLU 617 -1230
NAPEPLD -2667 5683
NCBP1 -1093 5859
NCBP2 -4299 4777
NCK1 -3877 1018
NCKAP1L 4619 -320
NCKIPSD -1667 667
NCOR1 3183 -530
NCOR2 4562 -1609
NCSTN 4654 1224
NDC1 -4582 6482
NEDD4L 2846 -1080
NEIL3 886 2175
NELFA -1404 3055
NELFB 829 -649
NELFCD -2102 6416
NELFE 2312 1529
NEU1 4492 1899
NF1 2485 -328
NFKB2 -2276 5251
NFKBIA 1525 6814
NHLRC1 -623 -774
NLRP3 3568 -847
NMT1 3435 5713
NMT2 -4537 1226
NOTCH1 2941 6291
NOTCH4 3739 4962
NOXA1 -1526 -376
NR3C1 973 3509
NR4A1 -431 1085
NTHL1 -1764 73
NUP107 -3437 6301
NUP133 -2181 935
NUP153 -709 4344
NUP155 -3052 3043
NUP160 -3890 1293
NUP188 -3651 2922
NUP205 -3468 1670
NUP210 -1977 690
NUP214 3636 4369
NUP35 -4479 -557
NUP37 126 3398
NUP43 -3608 6346
NUP50 1354 6706
NUP54 -3105 831
NUP62 -1130 4609
NUP85 -1192 4518
NUP88 -4449 7084
NUP93 -2021 2006
NUP98 1358 -747
NUS1 2466 1360
OGG1 -1600 -245
OS9 4487 -313
P2RX4 2912 398
PABPN1 -414 3061
PACS1 -2355 738
PAK2 3574 283
PAPSS1 4245 2272
PARP1 -3863 3582
PARP10 20 6412
PARP14 -2578 -97
PARP16 -3142 631
PARP4 3928 5235
PARP6 -1088 5464
PARP8 -1619 -1134
PARP9 1490 791
PC 3646 581
PCCB -1393 -1153
PDCD6IP 3370 5053
PDPK1 3218 346
PEBP1 -4410 4325
PGM1 2618 776
PHB -2116 4542
PIK3AP1 4435 1373
PIK3CA 946 1470
PIK3CD 2671 6109
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R3 995 3645
PIK3R4 -1326 2170
PLCG1 -4367 958
PLCG2 3848 2803
PLK2 -304 5974
PML -714 4575
PMM2 -1353 5311
PMS2 -1363 5491
POLR2A 2412 4046
POLR2B -903 5563
POLR2C -520 6356
POLR2D -2238 -614
POLR2E 2119 3712
POLR2F 1375 509
POLR2G 1618 1604
POLR2H -2765 6299
POLR2I -1337 5657
POLR2K -1277 3853
POM121 -1045 4681
POM121C -663 2061
POMGNT1 -3262 3331
POMT1 -3233 3935
POMT2 -1115 6243
PPIA -1958 4555
PPP1CB 2691 -340
PPP1CC 1107 5379
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5A 3674 -230
PPP2R5B 3304 -286
PPP2R5C -1671 7074
PPP2R5D 2123 3470
PPP2R5E -4 1402
PRDX1 1943 510
PRDX2 -1037 2503
PRKACA 4634 890
PRKACB -4510 1712
PRKAR1A 4338 -432
PRKAR1B 1934 1230
PRKAR2A 3132 -874
PRKCSH 2536 4698
PRR5 -2935 -347
PSEN1 4223 4955
PSEN2 -2281 -162
PSENEN 2445 4980
PSIP1 -4083 1734
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PSTPIP1 3982 680
PTEN 3783 4815
PTGER2 988 -850
PTGER4 -1371 5866
PTK2 -81 -475
PTPN11 2499 5062
PTPN12 3373 -982
PYCARD 4187 -1820
QKI 3485 2796
RAB5A 2871 3958
RAB7A 4110 -124
RAC1 4404 5541
RAC2 2815 4577
RAE1 1241 2634
RAF1 3220 6573
RAN -3182 1483
RANBP1 -3018 6300
RANBP2 -757 5165
RANGAP1 -3882 3626
RAP1A 3123 6569
RAP1B 3135 5968
RB1 3808 1119
RBBP4 -1544 4061
RBPJ 4163 1033
RBX1 2032 5883
RCC1 -1405 3680
RELA -360 4333
RFT1 324 5016
RHBDF2 3821 -1144
RHOG 4253 3664
RICTOR -2640 2833
RNF185 3066 5002
RNF213 -1390 7097
RNF5 -1369 6758
RNGTT 1072 14
RNMT -3141 6871
ROCK1 3502 2732
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS6KB2 502 4805
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
S1PR1 -1875 6791
SDC4 2632 2364
SEC13 2199 6211
SEH1L -4328 3577
SEL1L 3003 4058
SFPQ -2030 3947
SH3GL1 3225 6040
SHC1 3684 3205
SHOC2 2762 34
SIGMAR1 -2242 6976
SIN3A -2967 3819
SKP1 -1442 2680
SKP2 -1179 1707
SLC11A2 -506 2262
SLC12A6 3458 6142
SLC16A1 152 5451
SLC17A5 2173 -1547
SLC20A2 -2324 6714
SLC22A5 1948 5708
SLC24A4 3468 -1623
SLC25A4 -3766 6752
SLC26A2 -233 4122
SLC27A4 1697 -934
SLC29A3 2558 4866
SLC2A1 -2155 4076
SLC2A9 457 -1831
SLC33A1 -660 2774
SLC35A1 1364 3966
SLC35A3 -2221 -802
SLC35C1 817 5328
SLC35D1 -2406 4366
SLC37A4 -1568 2820
SLC39A4 864 -1513
SLC3A2 2791 744
SLC5A5 -3595 487
SMAD2 2413 1865
SMAD3 -3734 -363
SMAD4 -2091 -1925
SND1 1332 2977
SNF8 2422 5287
SNW1 1711 2517
SOD2 2190 6134
SOS1 -1564 -1986
SPON2 -1741 5932
SPRED1 1438 6065
SPRED2 4200 5462
SPRED3 382 5938
SRC -2136 -1476
SRD5A3 2617 2696
SSRP1 -4110 770
ST3GAL1 -2522 5845
ST3GAL2 4381 146
ST3GAL3 -1399 5837
ST3GAL4 3906 -1351
ST6GAL1 -4022 5784
ST6GALNAC3 4530 5569
ST6GALNAC4 97 -713
STAM 398 6491
STAM2 2689 3301
STAT1 -4254 4970
STAT3 3772 4995
STAT5A 2951 -1545
STAT5B 2832 1495
STRN 2310 6485
STX1A 1013 4174
STX1B -577 -1450
SUGT1 -650 5005
SUMO1 2118 3368
SUPT16H -4222 4839
SUPT4H1 1728 5918
SUPT5H -1710 2020
SYK 4235 431
SYVN1 813 -846
TAF10 3677 5288
TAF11 586 882
TAF12 3434 3413
TAF13 3598 3627
TAF15 -1524 4237
TAF2 182 292
TAF3 -1177 1363
TAF4 78 554
TAF4B -3905 4706
TAF5 -2526 3430
TAF6 -417 6843
TAF7 376 455
TAF9 -1869 4396
TALDO1 4236 4422
TBK1 2175 599
TBL1XR1 1687 2633
TBXAS1 4590 -1853
TCEA1 -1750 4154
TCF7L2 4387 1660
TFDP1 3248 2953
TFDP2 -3389 -1478
TGFA 4325 4632
TGFB1 2241 3769
TGFBR1 1602 -1264
TGFBR2 1403 2870
TICAM1 2805 1060
TIRAP 3210 1661
TLN1 4172 -983
TLR1 3767 -1113
TLR2 4229 4128
TLR3 -3155 2949
TLR5 4499 5701
TLR6 3198 -1201
TLR9 -1039 7204
TNKS -609 4477
TNKS2 924 2960
TPMT 2963 -348
TPR -1675 4616
TPST1 4596 2033
TPST2 4063 2245
TRAF3 -3457 7209
TRIM24 496 -938
TRIM27 3618 5498
TRIM28 -3382 3596
TSC2 775 3951
TSG101 3030 -488
TUBB -532 6248
TXN 3643 -1735
TXNIP -1224 6154
TXNRD1 3917 -1402
TYK2 3852 4072
UBA52 -1041 -69
UBAP1 4169 5038
UBB 509 5059
UBC 2477 3220
UBE2C 1221 4535
UBE2D1 3774 2741
UBE2E1 68 2408
UBE2I 14 5796
UBE2S 1470 -706
UNC93B1 4155 4749
UVRAG -1734 5731
VAMP1 -2837 4536
VAMP2 -3963 -1239
VAV1 3798 5834
VAV2 803 4134
VAV3 3247 -685
VCL 2594 3614
VCP 3034 1908
VEGFA 2025 87
VHL 1347 5209
VIPR1 -3102 5973
VPS25 3656 -962
VPS28 73 6115
VPS33B 2238 3025
VPS36 -1430 1902
VPS37A 2775 3939
VPS37B 2793 -1611
VPS37C 4268 4035
VPS4A 331 3112
VTA1 2056 3950
WASF1 4564 -830
WASF2 4427 -134
WASL 522 4645
WDR48 -3187 2818
WIPF1 919 -784
WIPF2 3524 -1018
XPO1 -925 6847
XRCC4 3419 5341
XRCC5 1586 1327
XRCC6 -2304 3282
YES1 -1029 5198
YWHAB 2512 2152
YWHAE 3796 1288
ZC3HAV1 -3264 3768
ZCRB1 392 438
ZFYVE9 -4371 3529
ZMYM2 1546 4446



Leishmania infection

Leishmania infection
metric value
setSize 109
pMANOVA 1.09e-08
p.adjustMANOVA 2.89e-07
s.dist 0.337
s.RNA 0.336
s.meth -0.0156
p.RNA 1.42e-09
p.meth 0.78




Top 20 genes
Gene RNA meth
GGT1 4656 -1937
PYCARD 4187 -1820
C3AR1 4610 -1596
TXN 3643 -1735
FGR 4616 -1075
RHBDF2 3821 -1144
WASF1 4564 -830
WIPF2 3524 -1018
ADCY4 3163 -1006
NLRP3 3568 -847
PRKAR2A 3132 -874
VAV3 3247 -685
PRKAR1A 4338 -432
ADCY7 1818 -981
NCKAP1L 4619 -320
PTGER2 988 -850
WIPF1 919 -784
WASF2 4427 -134
DPEP2 403 -1338
HRH2 4642 -109

Click HERE to show all gene set members

All member genes
RNA meth
ABI1 3644 3253
ABI2 -3635 -206
ABL1 1975 2469
ACTB 4359 5447
ACTG1 3825 1603
ACTR2 3672 3844
ACTR3 3554 5952
ADAM17 4436 4155
ADCY4 3163 -1006
ADCY7 1818 -981
ADCY9 -666 5439
ADM 4640 5105
ADORA2A 616 7186
ADRB2 -1555 2808
AHCYL1 2934 2692
ARPC1B 4422 1709
ARPC2 3659 2292
ARPC3 3630 3208
ARPC5 4209 2611
BAIAP2 -1012 2757
BRK1 1195 3071
C3AR1 4610 -1596
CALM1 263 4502
CASP1 1192 7031
CD247 -3684 6036
CDC42 3449 856
CREB1 -1458 1422
CRK 4199 6598
CYBA 4037 2019
CYFIP1 4176 256
CYFIP2 -1121 6159
DPEP2 403 -1338
DVL1 -2283 6368
DVL2 -3069 4884
DVL3 3827 161
ELMO1 1982 939
ELMO2 4026 6110
ENTPD1 3310 7219
ENTPD5 -557 451
FGR 4616 -1075
FURIN 4429 7181
FYN -1686 2793
FZD7 -2336 2145
GGT1 4656 -1937
GIPR -3140 -792
GNAI2 4151 3218
GNAI3 3381 2359
GNAS 2180 -60
GNB1 4261 2799
GNB2 4032 1879
GNB4 3205 1335
GNB5 -1662 6256
GNG2 1513 6500
GNG3 1124 7142
GNG4 858 6856
GNG5 4379 6512
GNG7 -3064 -499
GNGT2 859 7120
GRB2 4420 6241
HRH2 4642 -109
HSP90AB1 -4016 -1226
ITPR1 -1851 1789
ITPR2 2474 -44
ITPR3 -2973 2189
JUN -400 1283
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
MAPK8 -3916 4554
MYH9 3463 6146
MYO9B 4114 6777
NCK1 -3877 1018
NCKAP1L 4619 -320
NCKIPSD -1667 667
NFKB2 -2276 5251
NLRP3 3568 -847
NOXA1 -1526 -376
P2RX4 2912 398
PLCG1 -4367 958
PLCG2 3848 2803
PLK2 -304 5974
PRKACA 4634 890
PRKACB -4510 1712
PRKAR1A 4338 -432
PRKAR1B 1934 1230
PRKAR2A 3132 -874
PSTPIP1 3982 680
PTGER2 988 -850
PTGER4 -1371 5866
PTK2 -81 -475
PYCARD 4187 -1820
RAC1 4404 5541
RELA -360 4333
RHBDF2 3821 -1144
SRC -2136 -1476
SUGT1 -650 5005
SYK 4235 431
TXN 3643 -1735
TXNIP -1224 6154
VAV1 3798 5834
VAV2 803 4134
VAV3 3247 -685
VIPR1 -3102 5973
WASF1 4564 -830
WASF2 4427 -134
WASL 522 4645
WIPF1 919 -784
WIPF2 3524 -1018
YES1 -1029 5198



Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
metric value
setSize 40
pMANOVA 1.11e-08
p.adjustMANOVA 2.89e-07
s.dist 0.564
s.RNA -0.536
s.meth 0.175
p.RNA 4.43e-09
p.meth 0.0564




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPS2 -3934 6975
RPS12 -3875 6331
RPS5 -3931 6072
RPS15A -3671 6112
RPS16 -3602 5981
RPS29 -3767 5602
RPS3 -3960 4599
RPS7 -3610 4408
RPS18 -3528 4163
RPS11 -3324 4225
RPS10 -3531 3925
RPS20 -3978 3461
RPS15 -2379 5623
RPS23 -3904 2986
RPS27A -4269 2589
EIF3M -1552 5836
FAU -1142 6877
RPS25 -4251 1797
EIF3L -2749 2568

Click HERE to show all gene set members

All member genes
RNA meth
EIF2S1 71 4745
EIF2S2 1496 6254
EIF3A 275 5855
EIF3B -3969 -704
EIF3E -3292 503
EIF3F -1695 1471
EIF3G -773 3038
EIF3H -1803 3706
EIF3I -227 696
EIF3J -1432 737
EIF3K -390 6636
EIF3L -2749 2568
EIF3M -1552 5836
FAU -1142 6877
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072



Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs
metric value
setSize 122
pMANOVA 1.28e-08
p.adjustMANOVA 3.21e-07
s.dist 0.328
s.RNA -0.263
s.meth 0.195
p.RNA 5.58e-07
p.meth 0.000203




Top 20 genes
Gene RNA meth
RPS3A -4231 7068
RPL3 -4425 6753
RPL7 -4049 7010
RPS2 -3934 6975
RPL34 -4029 6515
RPLP2 -4010 6423
RPS12 -3875 6331
RPL32 -4069 6000
RPS5 -3931 6072
UPF3A -3318 6963
RPL13A -4073 5523
RPS15A -3671 6112
RPL26 -3455 6409
RPS16 -3602 5981
RPS29 -3767 5602
NCBP2 -4299 4777
RPL23A -4486 4560
RPS3 -3960 4599
RPLP0 -3580 4851
RPL13 -2751 6189

Click HERE to show all gene set members

All member genes
RNA meth
CASC3 3110 5106
CUL2 139 2207
DAG1 70 -94
EIF4A3 1061 4598
EIF4G1 4177 5766
ETF1 2922 151
FAU -1142 6877
GSPT1 -173 -1155
LDB1 -2835 1166
NCBP1 -1093 5859
NCBP2 -4299 4777
PABPC1 50 3011
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
RBX1 2032 5883
RNPS1 -3275 537
RPL10A -3701 3590
RPL11 -3694 -495
RPL13 -2751 6189
RPL13A -4073 5523
RPL14 -4315 -798
RPL15 -2942 1424
RPL17 -3576 2296
RPL18 -3621 4479
RPL18A -3688 4255
RPL22 -4090 1020
RPL23 -3211 2729
RPL23A -4486 4560
RPL26 -3455 6409
RPL26L1 2316 3971
RPL27A -3585 1697
RPL28 -1001 4755
RPL29 -3478 2875
RPL3 -4425 6753
RPL31 -3607 -34
RPL32 -4069 6000
RPL34 -4029 6515
RPL35 -2668 4824
RPL36 -2772 2877
RPL36AL -1574 6352
RPL37 -3012 5393
RPL37A -2404 4982
RPL38 -2902 4431
RPL39L -762 5080
RPL4 -3946 1394
RPL41 -2914 821
RPL6 -3632 1979
RPL7 -4049 7010
RPL8 -2273 5094
RPL9 -2986 844
RPLP0 -3580 4851
RPLP1 -2262 1521
RPLP2 -4010 6423
RPS10 -3531 3925
RPS11 -3324 4225
RPS12 -3875 6331
RPS15 -2379 5623
RPS15A -3671 6112
RPS16 -3602 5981
RPS18 -3528 4163
RPS19 -2833 -362
RPS2 -3934 6975
RPS20 -3978 3461
RPS23 -3904 2986
RPS24 -2104 -518
RPS25 -4251 1797
RPS26 -580 5517
RPS27A -4269 2589
RPS27L 344 1405
RPS28 -3328 -1180
RPS29 -3767 5602
RPS3 -3960 4599
RPS3A -4231 7068
RPS5 -3931 6072
RPS6 -4216 361
RPS7 -3610 4408
RPS8 -3366 -79
RPS9 1181 627
RPSA -2733 2072
SLIT1 2726 -1570
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
UPF2 652 3840
UPF3A -3318 6963
USP33 -346 774
ZSWIM8 3716 -1421



Post-translational protein modification

Post-translational protein modification
metric value
setSize 887
pMANOVA 1.29e-08
p.adjustMANOVA 3.21e-07
s.dist 0.12
s.RNA 0.115
s.meth 0.0355
p.RNA 1.84e-08
p.meth 0.0817




Top 20 genes
Gene RNA meth
FURIN 4429 7181
HIPK2 4260 7093
KLHL2 4531 6411
SOCS3 4419 6492
UBE2F 4050 6897
FBXL5 4033 6720
QSOX1 4636 5727
RAB1A 4010 6419
RHOT1 4536 5576
ST6GALNAC3 4530 5569
DNAJC3 3890 6472
NOD2 3807 6610
TGOLN2 4204 5919
FSTL3 4559 5264
ACTB 4359 5447
P4HB 4143 5718
COPA 4310 5455
DCAF6 3925 5807
LGALS1 4579 4933
NR1H2 3489 6463

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1807 1467
ACTB 4359 5447
ACTL6A -3054 -311
ACTR10 2879 4868
ACTR1A 4039 1932
ACTR5 -3474 -14
ACTR8 656 6298
ADAM10 4095 2760
ADAMTS10 -2542 -1433
ADAMTS13 -877 -1294
ADAMTS17 -2697 -67
ADAMTS6 -538 -624
ADAMTSL4 4434 1776
ADAMTSL5 -3415 -1286
ADRB2 -1555 2808
ADRM1 2084 4377
AGBL2 -1832 -1300
AGBL3 -3823 5375
AGBL5 -802 4297
AGTPBP1 3780 1896
ALG10 -1159 2276
ALG10B -3254 4343
ALG11 -994 5298
ALG12 620 1540
ALG14 1867 1973
ALG2 -1025 6978
ALG3 -1746 3191
ALG5 -1289 919
ALG6 -286 2858
ALG8 -1932 1673
ALG9 -3131 2495
AMDHD2 -1737 -609
AMFR 2566 -1825
ANK1 2094 947
ANK3 -2638 1579
ANKRD28 -2013 548
ANKRD9 3216 5043
ANO8 1562 4602
APC 1393 1992
APLP2 4509 -964
APP 2952 6623
ARCN1 2361 -399
ARF1 4345 -1821
ARF3 3661 274
ARF4 3856 4620
ARF5 3186 -939
ARFGAP1 429 6821
ARFGAP3 2679 724
ARRB1 1885 -1278
ARRB2 4237 2913
ARSA 2606 523
ARSB 4014 -1528
ARSG 29 4004
ARSK -4532 4078
ASB1 3322 6031
ASB13 361 1754
ASB2 -1279 6213
ASB6 686 -1069
ASB7 1157 6529
ASB8 2443 5453
ASXL1 -4028 1562
ASXL2 1352 4106
ATXN3 473 2715
ATXN7 -1488 508
AURKA 2658 4012
AURKB 1284 5274
AXIN1 -1579 -858
AXIN2 -3958 152
B3GALNT2 -288 4844
B3GNT2 2737 6093
B3GNT7 -2054 -1850
B3GNT8 3923 -1960
B3GNTL1 3211 1026
B4GALT1 3113 7043
B4GALT2 -389 6168
B4GALT3 -2836 4379
B4GALT4 2452 697
B4GALT5 4523 594
B4GALT6 1303 -552
B4GAT1 -2943 -1493
BABAM1 5 6889
BAP1 1781 6465
BARD1 1240 5972
BCL10 2493 2575
BECN1 2552 4915
BET1 -2521 1788
BET1L -1329 4145
BIRC2 511 6626
BIRC3 -4591 4817
BIRC5 2356 1965
BLM -1597 5263
BMI1 -3702 -805
BRCA1 2623 1586
BTBD1 -24 120
BTBD6 -1546 3006
BTRC -1864 -923
C1GALT1 -635 2851
CALM1 263 4502
CALR 2667 5714
CALU 3586 1962
CAND1 -2920 2163
CANX 1895 3479
CAPZA1 3861 999
CAPZA2 3520 4667
CAPZB 3889 -308
CASP8AP2 -4045 77
CBX4 2029 278
CBX8 1089 4611
CCNA2 256 4428
CCNF -435 392
CD55 4493 1455
CD59 1662 -1684
CDC20 1721 2639
CDC25A 79 3280
CDC34 3770 -408
CDC73 2258 5719
CDCA8 135 20
CDK1 -309 1888
CDKN2A -149 3478
CHD3 -3189 6050
CHST10 -1561 -970
CISH -1047 4928
CKAP4 4383 -987
CLSPN 1505 3082
CMAS 3709 -1296
CNIH1 487 6434
COG1 -3368 922
COG2 -2270 -1012
COG3 -1860 755
COG4 2622 645
COG5 -65 2084
COG6 -2374 3686
COG7 3564 3161
COG8 -437 2377
COMMD1 1341 5017
COMMD10 680 -63
COMMD2 298 3656
COMMD3 -955 -1962
COMMD4 -340 4192
COMMD5 1379 4631
COMMD6 -2571 609
COMMD7 2785 7051
COMMD8 2107 3300
COMMD9 2968 2239
COPA 4310 5455
COPB1 3055 2637
COPB2 3505 3476
COPE 3047 434
COPS2 964 6456
COPS3 1532 1714
COPS4 218 5826
COPS5 1335 3236
COPS6 30 782
COPS7A 3293 -66
COPS7B -1661 5099
COPS8 -3567 -1152
COPZ1 1087 97
COPZ2 -2063 -1672
CPM 3521 1461
CREBBP 2340 892
CSF1 -551 356
CSNK1D 2488 3046
CTBP1 800 6471
CTR9 896 -440
CTSA 4474 2720
CTSC 3824 1311
CTSZ 4030 -1980
CUL1 -4005 -1192
CUL2 139 2207
CUL3 2435 -873
CUL4A -88 1990
CUL5 -968 344
CUL7 1343 6188
CUL9 -409 -53
CYLD -4559 5706
DAD1 1197 6510
DAG1 70 -94
DAXX -1271 1574
DCAF10 2279 2650
DCAF11 1063 4304
DCAF13 -2402 862
DCAF16 -3667 6765
DCAF17 -4086 3480
DCAF4 -4477 6521
DCAF5 1227 6906
DCAF6 3925 5807
DCAF7 420 1667
DCAF8 -2057 2507
DCTN2 4315 -727
DCTN3 2651 2751
DCTN4 4328 4417
DCTN5 -160 6060
DCTN6 2977 6882
DCUN1D2 -826 2082
DCUN1D3 2252 -1028
DCUN1D4 -4368 2704
DCUN1D5 -206 5839
DDA1 1817 1316
DDB2 -147 -1223
DDX17 -1354 5635
DDX5 -3032 1804
DDX58 -3438 185
DERL1 -2237 363
DERL2 212 -1578
DHDDS 3049 383
DHPS -1228 4116
DNAJC24 -4076 1209
DNAJC3 3890 6472
DNMT1 -4341 4753
DNMT3A -1828 -1253
DNMT3B 1206 3249
DOHH -1640 1088
DOLK 597 4413
DOLPP1 -229 5476
DPAGT1 -886 1961
DPH1 -3640 3885
DPH2 -4445 4460
DPH3 2645 1751
DPH5 -2295 3623
DPH7 -2747 1787
DPM1 18 5921
DPM2 1067 6197
DPM3 155 5732
DTL -1044 1624
DYNC1H1 416 4434
DYNC1I2 3229 693
DYNC1LI1 3337 3242
DYNC1LI2 2324 -185
DYNLL1 1152 5151
DYNLL2 -1545 -924
EDEM1 -899 2710
EDEM2 4117 708
EEF1A1 -4143 2941
EEF2 -2045 4196
EEF2KMT -2767 4741
EID3 -3762 -1843
EIF5A -890 1107
ENGASE -3644 5131
EP300 3478 4901
EPAS1 4580 4596
ERCC8 1297 -1824
ETFB 3251 2959
FBXL12 -490 4059
FBXL14 -2216 6756
FBXL15 500 970
FBXL16 -4552 6378
FBXL18 3459 853
FBXL19 4322 -220
FBXL20 2347 1213
FBXL22 -2350 5652
FBXL3 87 2065
FBXL4 1692 1511
FBXL5 4033 6720
FBXL8 -734 5373
FBXO11 2992 7064
FBXO15 966 2131
FBXO21 -3050 6290
FBXO22 -876 -930
FBXO30 1495 1907
FBXO31 -4394 4756
FBXO32 -4013 6488
FBXO4 -4249 106
FBXO6 1775 92
FBXO7 1597 2923
FBXO9 4538 3195
FBXW11 2170 -1508
FBXW2 4166 2654
FBXW4 -3367 136
FBXW5 1572 -1872
FBXW7 -1004 6667
FBXW8 -2115 4559
FEM1A 1084 3788
FEM1B 861 7253
FKBP8 2932 4140
FN3KRP -4563 3811
FOXK1 479 4114
FOXK2 907 -1549
FPGT 2285 -1460
FSTL3 4559 5264
FUCA1 2386 1656
FUCA2 2692 -1236
FUOM -1913 -1357
FURIN 4429 7181
FUT8 -2403 6348
GALNT10 2503 -306
GALNT11 -186 3795
GALNT12 -3740 -1602
GALNT2 4471 -1749
GALNT3 3300 -712
GALNT4 3460 6113
GALNT6 1406 -1494
GALNT7 2465 -831
GAN -11 3655
GANAB 838 4411
GATA3 -4581 6274
GBF1 2006 4985
GCNT1 4613 2423
GFPT1 -1234 -718
GGCX 2712 4622
GLB1 4153 1828
GMDS 1541 4581
GMPPA 2164 2573
GMPPB -615 4250
GNE -1080 2902
GNPNAT1 -4614 2186
GOLGA2 3731 -1361
GOLGB1 -1140 5355
GOLM1 -95 -842
GORASP1 3039 -281
GOSR1 -399 -852
GOSR2 787 5880
GPAA1 2950 2884
GPS1 -900 6190
HDAC1 -207 3287
HDAC2 -1260 5864
HDAC4 4304 887
HDAC7 1275 -487
HGS 2818 4351
HIF1A 3440 2448
HIPK2 4260 7093
HLA-A -2315 -1094
HLA-B 157 -730
HNRNPC 1974 213
HNRNPK 2115 3141
HSP90B1 -436 2127
ICMT 465 2626
IDE 2023 3279
IFIH1 -2787 2681
IGFBP4 -334 -1803
IKBKE 2509 6705
INCENP 590 5539
ING2 489 1059
INO80 -404 3349
INO80B -888 1724
INO80C 2456 1032
INO80D -225 1222
INO80E -3097 6577
JOSD1 1959 4692
JOSD2 3888 178
KAT2A -4179 1343
KAT2B -105 4028
KBTBD6 -1389 80
KBTBD7 2876 -381
KBTBD8 -1089 834
KCTD6 2053 -621
KCTD7 -4114 1682
KDELR1 3788 4935
KDELR2 2828 1832
KDM1B 3526 -425
KEAP1 3048 1379
KIN 2214 1775
KLHL11 -1676 5349
KLHL2 4531 6411
KLHL20 -2158 1429
KLHL21 1141 5917
KLHL22 -4003 1129
KLHL25 -4246 4489
KLHL5 -2834 3248
KTN1 229 -1506
L3MBTL2 -3725 2967
LAMB2 -214 1884
LEO1 197 4252
LGALS1 4579 4933
LMAN1 -3797 5995
LMAN2 3597 6266
LMAN2L 797 1715
LMO7 -4378 7262
LRR1 -1924 3790
LRRC41 4069 2878
LTBP1 1295 3835
LYPD3 -3043 3842
MAN1A1 4431 1559
MAN1A2 -543 3421
MAN1B1 -301 6524
MAN1C1 -4535 145
MAN2A1 -1576 2421
MAN2A2 3764 2485
MANEA -266 2606
MAP3K7 1566 -147
MAT2B -3256 1526
MAVS 2866 4281
MBD1 820 -761
MBD5 2213 5474
MBD6 3738 -1066
MBTPS1 1497 2401
MCFD2 2059 2397
MCRS1 -630 5322
MDC1 -3376 4410
MDM2 2338 2095
MDM4 -209 5729
MEN1 -2694 1903
METTL21A 1771 1417
METTL22 3847 -824
MFGE8 1383 1680
MGAT1 3035 3827
MGAT2 1526 4676
MGAT4A -2946 3777
MGAT4B 3073 -1114
MGAT5 -2286 5133
MIA3 -1636 4042
MLEC 526 2183
MOGS -1008 5808
MPDU1 3733 377
MPI -4065 1103
MUC1 1680 6715
MUC12 -806 4641
MUC5B 2049 -1745
MUL1 1432 3036
MVD 1014 190
MYSM1 -958 -129
NAE1 -4107 289
NAGK -1766 5193
NANP -467 1185
NANS 3566 2672
NAPA 2576 3102
NAPB 239 2662
NAPG 2087 2684
NCOA2 2227 2432
NCOR2 4562 -1609
NDC1 -4582 6482
NEDD8 2980 -105
NEGR1 222 4799
NEU1 4492 1899
NEU3 -818 -1014
NEURL2 -684 3781
NFKB2 -2276 5251
NFKBIA 1525 6814
NFRKB -26 1074
NGLY1 -388 1920
NICN1 1443 6397
NLRP3 3568 -847
NOD1 -1776 -321
NOD2 3807 6610
NOP58 -4534 1333
NPL 4638 -522
NR1H2 3489 6463
NR1H3 1154 6206
NR2C1 -3321 4894
NR3C1 973 3509
NR3C2 -4466 5083
NR4A2 -870 3570
NSMCE1 587 5931
NSMCE2 1655 6829
NSMCE4A -3926 4283
NTNG2 3325 6600
NUB1 -3992 1636
NUCB1 4369 2380
NUP107 -3437 6301
NUP133 -2181 935
NUP153 -709 4344
NUP155 -3052 3043
NUP160 -3890 1293
NUP188 -3651 2922
NUP205 -3468 1670
NUP210 -1977 690
NUP214 3636 4369
NUP35 -4479 -557
NUP37 126 3398
NUP43 -3608 6346
NUP50 1354 6706
NUP54 -3105 831
NUP62 -1130 4609
NUP85 -1192 4518
NUP88 -4449 7084
NUP93 -2021 2006
NUP98 1358 -747
NUS1 2466 1360
OS9 4487 -313
OTUB1 928 3150
OTUD3 -2861 5747
OTUD7B -2426 42
OTULIN -597 6432
P4HB 4143 5718
PAF1 1581 7080
PARK7 1552 1769
PARP1 -3863 3582
PCNA -2610 4383
PDIA3 1941 4846
PDIA6 2144 414
PEX10 1 3738
PEX12 -2509 2761
PEX13 -16 4905
PEX14 3276 3628
PEX2 2280 2647
PEX5 2066 -1621
PGAP1 -3663 4633
PGM3 -2411 -750
PHC1 -3966 -1213
PHC2 4569 4887
PHC3 -1507 4977
PIAS1 2064 2845
PIAS2 -1067 6536
PIAS3 512 2561
PIAS4 3189 1744
PIGC -1348 6801
PIGF 2286 3309
PIGH -2253 133
PIGK -2153 6709
PIGL -3523 2045
PIGM -811 942
PIGN 1371 -636
PIGO 99 3619
PIGP -2376 1659
PIGQ -569 3678
PIGS 3883 3189
PIGT 2260 5280
PIGU -3949 1214
PIGV 1673 5610
PIGW -4444 3707
PIGX 42 288
PLAUR 4124 -861
PML -714 4575
PMM1 2391 3931
PMM2 -1353 5311
PNPLA2 3862 281
POFUT2 -3267 5110
POLB -2979 6236
POM121 -1045 4681
POM121C -663 2061
POMGNT1 -3262 3331
POMGNT2 264 -1104
POMK 850 326
POMT1 -3233 3935
POMT2 -1115 6243
PPP6C 1747 6979
PPP6R1 3172 -1034
PPP6R3 1368 -1719
PRKCSH 2536 4698
PRKDC -2099 6476
PRMT3 -1014 4550
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PTEN 3783 4815
PTP4A2 2560 6576
PTRH2 -1149 1997
PUM2 -2229 6128
QSOX1 4636 5727
RAB10 4485 3067
RAB11A 2969 2440
RAB11B 1143 3899
RAB12 17 -468
RAB14 2619 -378
RAB18 2483 2764
RAB19 2009 5461
RAB1A 4010 6419
RAB1B 3988 4467
RAB22A -478 -722
RAB23 -221 4707
RAB24 3244 -168
RAB27A 3787 222
RAB29 -859 202
RAB2A 4023 2859
RAB2B -1969 3256
RAB30 -4174 2925
RAB33B 1996 5180
RAB34 3652 -711
RAB35 2447 905
RAB37 -885 409
RAB3A 2502 4348
RAB3D 4330 1148
RAB40B -4165 2349
RAB40C 3543 3501
RAB43 1830 5468
RAB4A 480 559
RAB4B 3084 4688
RAB5A 2871 3958
RAB5B 3004 1957
RAB5C 3866 797
RAB6A 3957 3323
RAB7A 4110 -124
RAB8A 2807 1826
RAB8B 2955 1101
RABGGTA 887 4691
RABGGTB -2900 7207
RAD18 -4585 450
RAD21 -782 5118
RAD23A 1451 3689
RAD23B 4099 -270
RAD52 330 4781
RAE1 1241 2634
RANBP2 -757 5165
RANGAP1 -3882 3626
RARA 4270 2132
RBBP5 -425 2829
RBX1 2032 5883
RCE1 -1527 3297
RCN1 -1976 -1169
RECK -4000 912
RELA -360 4333
RFT1 324 5016
RHOA 3965 4033
RHOT1 4536 5576
RING1 -1660 1003
RNF103 -76 4240
RNF123 3286 5285
RNF135 4465 -1615
RNF139 217 9
RNF146 4444 1611
RNF152 1877 6386
RNF168 1773 394
RNF181 1414 2837
RNF185 3066 5002
RNF2 368 2513
RNF20 2640 4638
RNF40 3985 3206
RNF5 -1369 6758
RNF7 3181 5841
RORA -4196 6933
RPA1 -4364 6282
RPN1 3105 6053
RPN2 3531 5501
RPS2 -3934 6975
RPS27A -4269 2589
RRAGA 3206 6806
RTF1 1637 6570
RTN4RL2 2750 2502
RUVBL1 -3041 4751
RWDD3 -1707 -785
SAE1 -2528 5071
SAFB 417 4864
SAR1B 2728 3060
SATB1 -4181 -561
SATB2 3691 2932
SCMH1 -4153 95
SEC13 2199 6211
SEC16A 3331 4812
SEC22A -3026 2581
SEC22C -1101 5700
SEC23A 2702 1833
SEC23IP 177 1231
SEC24A 3575 4762
SEC24B 2183 -13
SEC24C 2332 -336
SEC24D 4409 1527
SEC31A 1591 2523
SEH1L -4328 3577
SEL1L 3003 4058
SENP1 48 1369
SENP2 1811 3787
SENP5 -509 2708
SENP8 837 4664
SHISA5 2613 -1512
SHPRH -2009 303
SIAH2 2586 6697
SIN3A -2967 3819
SKP1 -1442 2680
SKP2 -1179 1707
SLC17A5 2173 -1547
SLC35A1 1364 3966
SLC35C1 817 5328
SMAD1 4645 206
SMAD2 2413 1865
SMAD3 -3734 -363
SMAD4 -2091 -1925
SMAD7 100 1420
SMC3 -1506 623
SMC5 -2481 -1125
SMC6 -1205 2156
SMURF2 -2759 3523
SOCS2 -1172 6479
SOCS3 4419 6492
SOCS5 -381 466
SP100 3530 2285
SP3 1606 1348
SPON2 -1741 5932
SPSB1 1120 582
SPSB3 -1197 2224
SPTAN1 -4215 -407
SPTBN1 -3763 3657
SPTBN5 914 2256
SRD5A3 2617 2696
ST3GAL1 -2522 5845
ST3GAL2 4381 146
ST3GAL3 -1399 5837
ST3GAL4 3906 -1351
ST3GAL5 -2316 2470
ST3GAL6 1264 6719
ST6GAL1 -4022 5784
ST6GALNAC3 4530 5569
ST6GALNAC4 97 -713
ST6GALNAC6 -2775 1536
ST8SIA1 -4072 3651
ST8SIA4 3565 3826
STAG1 -1529 5283
STAM 398 6491
STAM2 2689 3301
STAMBP 2434 3673
STAMBPL1 -3587 -371
STT3A 866 5397
STX17 -3674 -218
STX5 3382 5926
SUDS3 1113 1432
SUMF1 4171 -728
SUMF2 -2533 38
SUMO1 2118 3368
SUMO3 3165 1958
SYVN1 813 -846
TAF10 3677 5288
TBC1D20 747 1409
TDG 2035 -1070
TFPT 2369 2225
TGFA 4325 4632
TGFB1 2241 3769
TGFBR1 1602 -1264
TGFBR2 1403 2870
TGOLN2 4204 5919
THRA -1356 761
TMED10 -974 3393
TMED2 2394 5946
TMED3 1979 5786
TMED7 2142 -959
TMED9 3384 1623
TMEM115 2240 -632
TMEM129 546 6587
TNFAIP3 -891 6105
TNIP1 4073 2892
TNIP2 2642 287
TNKS -609 4477
TNKS2 924 2960
TOMM20 -3494 6657
TOP1 2895 -780
TOP2A 1184 5955
TOP2B -1400 3557
TOPORS -278 1741
TP53 -4050 2709
TP53BP1 -3723 2265
TPGS1 671 7098
TPGS2 816 352
TPR -1675 4616
TPST1 4596 2033
TPST2 4063 2245
TRAF2 -3445 5765
TRAF3 -3457 7209
TRAF6 957 -71
TRAPPC1 3635 5233
TRAPPC10 117 6987
TRAPPC2L -945 1131
TRAPPC3 2092 -470
TRAPPC4 -960 1676
TRAPPC5 1256 29
TRAPPC6A -4241 -1706
TRAPPC6B 557 1818
TRAPPC9 2575 -816
TRIM13 265 3356
TRIM25 4384 446
TRIM27 3618 5498
TRIM28 -3382 3596
TRRAP -967 6328
TSTA3 1222 6518
TTL 1114 252
TTLL1 -1285 595
TTLL11 -2006 4808
TTLL12 1753 6247
TTLL3 1571 3167
TTLL4 3501 -1222
TTLL5 916 5219
TTLL7 2838 4232
TUBA1A 3240 -625
TUBA1B 3137 4760
TUBA1C 2990 2535
TUBB2A 4352 229
TUBB4B 2796 7163
UAP1 -2723 1462
UBA2 -3491 435
UBA3 2970 4052
UBA52 -1041 -69
UBA6 1636 -917
UBB 509 5059
UBC 2477 3220
UBE2B 2042 5147
UBE2C 1221 4535
UBE2D1 3774 2741
UBE2D2 521 2134
UBE2D3 3445 3005
UBE2E1 68 2408
UBE2E3 288 -777
UBE2F 4050 6897
UBE2G1 1799 214
UBE2G2 -4319 6799
UBE2H 3432 1146
UBE2I 14 5796
UBE2J2 2786 6013
UBE2K 2378 3260
UBE2L3 3091 119
UBE2M 2900 2052
UBE2N -315 4834
UBE2Q2 -4044 -223
UBE2R2 4178 -1209
UBE2S 1470 -706
UBE2T -3014 6619
UBE2V2 389 3547
UBE2W 2359 5413
UBE2Z -2330 6571
UBXN1 840 4311
UBXN7 1123 4182
UCHL3 -1050 763
UCHL5 -2318 2394
UGGT1 2924 3816
UHRF2 -3179 1524
UIMC1 4130 -439
USO1 1288 3424
USP10 1892 792
USP12 -109 1842
USP13 -1135 2905
USP14 -823 4774
USP15 1381 4187
USP16 -2358 -148
USP18 -1086 -1013
USP19 1824 3776
USP20 -4097 6825
USP21 -2234 -293
USP22 2382 -803
USP24 -1835 -862
USP25 -401 6455
USP28 -1822 -180
USP3 4373 4117
USP30 -1124 1984
USP33 -346 774
USP34 -210 1573
USP4 4141 -254
USP42 -1680 752
USP44 -2427 5513
USP47 -223 6427
USP48 391 1169
USP49 3514 1552
USP5 -1774 1291
USP7 2187 3259
USP8 2773 4109
VCP 3034 1908
VCPIP1 720 3335
VCPKMT 82 -1764
VDAC1 990 569
VDAC3 236 3667
VDR 4632 3980
VHL 1347 5209
WAC 3446 3037
WDR20 -330 6108
WDR48 -3187 2818
WDR5 -824 1100
WDR61 -718 1522
WDTC1 3910 4227
WFS1 -3079 6366
WRN -4354 6296
WSB1 4407 4175
WSB2 3945 1993
XPC -2917 5033
XRCC4 3419 5341
YKT6 2709 3314
YOD1 2655 471
YY1 -1642 1468
ZBTB16 3255 -42
ZNF131 -4138 4942



EPH-Ephrin signaling

EPH-Ephrin signaling
metric value
setSize 54
pMANOVA 2.2e-08
p.adjustMANOVA 5.35e-07
s.dist 0.465
s.RNA 0.465
s.meth 0.0156
p.RNA 3.54e-09
p.meth 0.843




Top 20 genes
Gene RNA meth
CLTC 4203 7259
APH1B 3617 6785
RAC1 4404 5541
ACTB 4359 5447
MYH9 3463 6146
ACTR3 3554 5952
PSEN1 4223 4955
AP2S1 3281 6039
ITSN1 4401 3959
CLTCL1 3815 4511
RHOA 3965 4033
SDCBP 3944 3834
ACTR2 3672 3844
AP2M1 3567 3723
PSENEN 2445 4980
MYH10 2136 5544
ARPC3 3630 3208
ADAM10 4095 2760
ARPC5 4209 2611
EFNA4 1544 6655

Click HERE to show all gene set members

All member genes
RNA meth
ACTB 4359 5447
ACTG1 3825 1603
ACTR2 3672 3844
ACTR3 3554 5952
ADAM10 4095 2760
AP2A1 4623 -316
AP2M1 3567 3723
AP2S1 3281 6039
APH1A 1304 -119
APH1B 3617 6785
ARHGEF7 -611 330
ARPC1B 4422 1709
ARPC2 3659 2292
ARPC3 3630 3208
ARPC5 4209 2611
CDC42 3449 856
CFL1 3970 1646
CLTA 3106 -546
CLTB 3122 -918
CLTC 4203 7259
CLTCL1 3815 4511
DNM1 2517 1607
EFNA3 -2523 6086
EFNA4 1544 6655
EPHA4 -4626 3017
EPHB6 -3680 4825
FYN -1686 2793
GIT1 -3007 -1972
HRAS -2340 -823
ITSN1 4401 3959
LIMK1 3007 -1750
LIMK2 3246 116
MYH10 2136 5544
MYH9 3463 6146
MYL12A 2426 3674
MYL6 4089 2012
NCK2 -480 1378
NCSTN 4654 1224
PAK1 3814 2452
PAK2 3574 283
PSEN1 4223 4955
PSEN2 -2281 -162
PSENEN 2445 4980
PTK2 -81 -475
RAC1 4404 5541
RASA1 1788 3434
RHOA 3965 4033
ROCK1 3502 2732
SDCBP 3944 3834
SRC -2136 -1476
VAV2 803 4134
VAV3 3247 -685
WASL 522 4645
YES1 -1029 5198



Cytokine Signaling in Immune system

Cytokine Signaling in Immune system
metric value
setSize 496
pMANOVA 2.31e-08
p.adjustMANOVA 5.5e-07
s.dist 0.153
s.RNA 0.129
s.meth 0.0811
p.RNA 1.24e-06
p.meth 0.00233




Top 20 genes
Gene RNA meth
PRKCD 4519 6360
SOCS3 4419 6492
ITGB2 4462 6426
TNFRSF1B 4053 6870
MAPK1 4560 6099
CRK 4199 6598
KSR1 3863 7147
GRB2 4420 6241
PTPN9 4524 6096
TRIM8 4192 6375
PTPN6 4000 6542
NOD2 3807 6610
IRS2 3955 6152
EIF4G1 4177 5766
ALOX5 4460 5386
P4HB 4143 5718
IL19 3167 7266
SPRED2 4200 5462
VAV1 3798 5834
SMARCA4 3223 6792

Click HERE to show all gene set members

All member genes
RNA meth
AAAS -1807 1467
ABCE1 -4598 6006
ABHD17A -1670 -550
ABHD17B -649 -676
ADAM17 4436 4155
ADAR 1862 3087
AIP -657 6684
AKT1 1891 1109
AKT2 781 5431
ALOX5 4460 5386
APBB1IP 4238 3821
APP 2952 6623
ARF1 4345 -1821
ARIH1 90 3751
ARL2 -939 244
ARRB1 1885 -1278
ARRB2 4237 2913
ATF1 1229 2989
B2M -2207 -9
BATF 1760 6679
BCL2 -3030 7022
BCL2L1 1477 5970
BCL6 4540 3669
BIRC2 511 6626
BIRC3 -4591 4817
BIRC5 2356 1965
BRAF 1030 -1526
BRAP 2450 -135
BRWD1 -2774 -349
BST2 -306 -1935
BTRC -1864 -923
CALM1 263 4502
CAMK2D -4530 -529
CAMK2G -152 6718
CANX 1895 3479
CAPZA1 3861 999
CASP1 1192 7031
CASP3 2079 5691
CBL 3732 1012
CCND1 -2034 1006
CCR1 3886 -1921
CD4 -2816 909
CD44 3690 4898
CDC42 3449 856
CDKN1A 2283 2427
CEBPD 4308 -907
CFL1 3970 1646
CHUK 3354 1111
CISH -1047 4928
CNN2 2979 -418
CREB1 -1458 1422
CRK 4199 6598
CRKL 1455 5167
CSF1 -551 356
CSK 3371 4890
CTF1 2571 543
CUL1 -4005 -1192
CUL3 2435 -873
CXCL2 440 -1990
DDX58 -3438 185
DLG1 -2579 358
DLG2 -429 -40
DLG4 3550 2607
DUSP1 2453 2023
DUSP10 174 4700
DUSP16 -3228 28
DUSP2 -2620 7009
DUSP3 2975 2260
DUSP4 -384 2494
DUSP5 -263 6280
DUSP6 -702 -1943
DUSP7 -732 722
EDARADD -3735 6841
EGR1 -1170 1893
EIF2AK2 1466 683
EIF4A1 2418 881
EIF4A2 -4411 3601
EIF4A3 1061 4598
EIF4E 1167 6721
EIF4E2 2223 5876
EIF4E3 3349 -661
EIF4G1 4177 5766
EIF4G2 2274 6373
EIF4G3 4441 1034
ERBB2 -2008 4160
FBXW11 2170 -1508
FGF9 -3638 997
FLNB 2441 675
FLT3LG -4600 6677
FNTA -1333 694
FNTB 647 -1385
FOS 692 5647
FOXO1 -4458 3034
FOXO3 3816 5023
FRS2 -959 -882
FRS3 2713 6525
FYN -1686 2793
GAB2 4007 2390
GATA3 -4581 6274
GBP3 -4088 89
GOLGA7 648 3104
GRB2 4420 6241
GRIN2D 3552 3069
GSTO1 3901 3633
HBEGF 646 -1007
HERC5 -2560 -1038
HIF1A 3440 2448
HLA-A -2315 -1094
HLA-B 157 -730
HLA-C 725 4449
HLA-E 766 5636
HLA-F -2858 2974
HLA-H -726 4989
HMGB1 -1409 3222
HNRNPA2B1 979 2721
HNRNPF 839 5857
HRAS -2340 -823
HSP90AA1 -729 6210
HSP90B1 -436 2127
HSPA9 -4169 6551
ICAM1 170 2036
ICMT 465 2626
IFI30 4212 -1604
IFI35 1098 1292
IFI6 1316 5537
IFIT1 -1523 312
IFIT2 -2954 1477
IFIT3 -1411 6161
IFIT5 -2519 3745
IFITM1 -894 6985
IFNAR1 3467 1219
IFNAR2 3120 1115
IFNGR1 4425 4124
IFNGR2 4592 4231
IKBKB -510 -912
IL10RA -106 5518
IL10RB 4566 -1076
IL12A -3557 -1317
IL12RB1 -2265 6632
IL12RB2 -3177 -1861
IL15 -1033 3611
IL15RA 67 -1087
IL16 -1859 5458
IL17C 1334 -1130
IL17RA 4468 130
IL17RC -1500 1939
IL18BP -1294 -1640
IL18R1 3014 6744
IL19 3167 7266
IL1RAP 3464 -1122
IL21R -3300 2722
IL23A -4577 7078
IL27RA 1558 6659
IL2RA -2715 6868
IL2RB -4098 7237
IL32 -4046 7268
IL4R 3584 1274
IL6R 2774 5066
IL6ST -361 1708
INPP5D 3164 55
INPPL1 3940 588
IP6K2 -1388 799
IQGAP1 4024 587
IRAK2 -1227 4686
IRAK3 4491 666
IRF1 -2390 5832
IRF2 3133 2365
IRF3 -2846 4241
IRF4 -3348 5941
IRF5 2869 -1651
IRF7 856 3556
IRF9 -803 4775
IRS1 -2666 4308
IRS2 3955 6152
ISG15 -2022 6541
ISG20 -2977 7060
ITGB2 4462 6426
JAK1 -2308 -283
JAK2 1159 6489
JUN -400 1283
JUNB 2048 5018
KBTBD7 2876 -381
KPNA1 -443 4423
KPNA2 66 4421
KPNA3 -12 4400
KPNA4 2166 5000
KPNA5 -4039 1847
KPNB1 1964 1140
KRAS 2245 3139
KSR1 3863 7147
LAMTOR2 3191 -1342
LAMTOR3 2265 957
LCK -4408 7246
LCP1 4185 4312
LGALS9 3845 -1462
LMNB1 4349 1051
LTA -4469 7256
LTB -4525 5586
LYPLA1 3207 2159
MAP2K1 4239 1533
MAP2K2 2556 6410
MAP2K3 4152 2411
MAP2K4 2698 4764
MAP2K6 4437 4792
MAP2K7 -54 1764
MAP3K11 4002 1270
MAP3K14 -4023 4221
MAP3K3 4145 3121
MAP3K7 1566 -147
MAP3K8 4603 3266
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
MAPK7 3610 -244
MAPK8 -3916 4554
MAPK9 -1532 157
MAPKAPK2 3498 3265
MAPKAPK3 4597 2896
MARK3 4168 3805
MEF2A 3826 3013
MIF -2780 3355
MT2A 595 1186
MTAP -2689 2271
MUC1 1680 6715
MX1 -1283 -1016
MX2 4243 1798
MYD88 4594 1945
NDC1 -4582 6482
NEDD4 3884 -1106
NF1 2485 -328
NFKB2 -2276 5251
NFKBIA 1525 6814
NFKBIB 2303 5574
NKIRAS1 -1505 348
NKIRAS2 4544 -1132
NOD1 -1776 -321
NOD2 3807 6610
NUP107 -3437 6301
NUP133 -2181 935
NUP153 -709 4344
NUP155 -3052 3043
NUP160 -3890 1293
NUP188 -3651 2922
NUP205 -3468 1670
NUP210 -1977 690
NUP214 3636 4369
NUP35 -4479 -557
NUP37 126 3398
NUP43 -3608 6346
NUP50 1354 6706
NUP54 -3105 831
NUP62 -1130 4609
NUP85 -1192 4518
NUP88 -4449 7084
NUP93 -2021 2006
NUP98 1358 -747
OAS1 1163 -1507
OAS2 -1852 6618
OAS3 -1975 616
OASL 1791 5929
OSM 2650 1355
P4HB 4143 5718
PAK2 3574 283
PAQR3 -786 2041
PDCD4 -4504 4220
PDE12 -463 6083
PDE3B -4123 3507
PDE6D 1876 4822
PDPK1 3218 346
PEA15 -1894 7145
PEBP1 -4410 4325
PELI1 1886 1867
PELI2 2557 7035
PELI3 3582 -1123
PHB -2116 4542
PIAS1 2064 2845
PIK3CA 946 1470
PIK3CD 2671 6109
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R3 995 3645
PIK3R4 -1326 2170
PIM1 2364 1390
PIN1 -43 4014
PITPNA 3938 3616
PLCG1 -4367 958
PML -714 4575
POM121 -1045 4681
POM121C -663 2061
POU2F1 2656 3909
PPIA -1958 4555
PPM1B 3092 -144
PPP1CB 2691 -340
PPP1CC 1107 5379
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5A 3674 -230
PPP2R5B 3304 -286
PPP2R5C -1671 7074
PPP2R5D 2123 3470
PPP2R5E -4 1402
PPP5C -1013 5721
PRKACA 4634 890
PRKCD 4519 6360
PRKCQ -4282 4208
PRTN3 -1895 5621
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PTK2 -81 -475
PTK2B 4451 4529
PTPN1 4210 699
PTPN11 2499 5062
PTPN12 3373 -982
PTPN13 -2147 6850
PTPN18 4484 3436
PTPN2 3642 181
PTPN23 1520 5427
PTPN4 -3841 784
PTPN6 4000 6542
PTPN7 -570 2323
PTPN9 4524 6096
PTPRA 2152 6358
RAE1 1241 2634
RAF1 3220 6573
RALA -2065 2302
RALGDS -3164 6406
RANBP2 -757 5165
RANBP9 2528 884
RAP1A 3123 6569
RAP1B 3135 5968
RAPGEF1 1580 6445
RASA1 1788 3434
RASA2 -74 2632
RASA3 -4225 187
RASAL1 -1471 5685
RASAL3 -3093 2544
RASGRP1 -4340 5888
RASGRP3 -3423 760
RBX1 2032 5883
RCE1 -1527 3297
RELA -360 4333
RELB 390 577
RGL1 4405 3381
RGL2 2856 4879
RNASEL 4301 3400
RORA -4196 6933
RPLP0 -3580 4851
RPS27A -4269 2589
RPS6KA1 4497 -1859
RPS6KA2 1476 2117
RPS6KA5 -4234 1991
S1PR1 -1875 6791
SAMHD1 3465 6191
SEC13 2199 6211
SEH1L -4328 3577
SH2B1 -2743 1436
SHC1 3684 3205
SHOC2 2762 34
SIGIRR -2919 6807
SKP1 -1442 2680
SMAD3 -3734 -363
SMARCA4 3223 6792
SNRPA1 -3020 1539
SOCS1 1954 4130
SOCS2 -1172 6479
SOCS3 4419 6492
SOCS5 -381 466
SOD1 -2469 1838
SOD2 2190 6134
SOS1 -1564 -1986
SOS2 3721 3699
SP100 3530 2285
SPRED1 1438 6065
SPRED2 4200 5462
SPRED3 382 5938
SPTAN1 -4215 -407
SPTBN1 -3763 3657
SPTBN5 914 2256
SQSTM1 -377 658
SRC -2136 -1476
STAT1 -4254 4970
STAT2 -1754 5933
STAT3 3772 4995
STAT4 -4008 4203
STAT5A 2951 -1545
STAT5B 2832 1495
STAT6 3358 3854
STX1A 1013 4174
STX3 3765 2712
STX4 2105 1609
STXBP2 4595 -155
SUMO1 2118 3368
SYK 4235 431
SYNGAP1 -3633 1191
TAB2 605 6401
TALDO1 4236 4422
TBK1 2175 599
TCP1 -1018 -448
TEC 3744 170
TGFA 4325 4632
TGFB1 2241 3769
THEM4 -4605 809
TLN1 4172 -983
TLR9 -1039 7204
TNF -1302 -526
TNFRSF12A 3115 681
TNFRSF1A 4400 -1548
TNFRSF1B 4053 6870
TNFRSF25 -4616 6989
TNFSF13 4042 -1364
TNFSF13B 3490 -384
TNFSF14 2181 7178
TNFSF9 811 447
TNIP2 2642 287
TOLLIP 3698 664
TP53 -4050 2709
TPR -1675 4616
TRAF2 -3445 5765
TRAF3 -3457 7209
TRAF6 957 -71
TRIB3 207 3767
TRIM14 2011 1982
TRIM2 -3942 646
TRIM21 1429 -1673
TRIM22 -952 2278
TRIM25 4384 446
TRIM26 1026 3540
TRIM35 -2444 1556
TRIM38 2198 4883
TRIM45 -1684 -1041
TRIM46 -4061 3136
TRIM5 1579 395
TRIM62 -1143 3890
TRIM68 -3239 -539
TRIM8 4192 6375
TXLNA -114 7007
TYK2 3852 4072
UBA3 2970 4052
UBA52 -1041 -69
UBA7 -1692 -1591
UBB 509 5059
UBC 2477 3220
UBE2E1 68 2408
UBE2L6 -3166 1295
UBE2M 2900 2052
UBE2N -315 4834
UBE2V1 688 2792
USP18 -1086 -1013
VAMP2 -3963 -1239
VAV1 3798 5834
VCL 2594 3614
VEGFA 2025 87
VIM 4522 3780
VRK3 2298 2903
WDR83 2132 5497
XAF1 -2044 -1464
YES1 -1029 5198
YWHAB 2512 2152
YWHAZ 2353 4294
ZEB1 -3353 5937



PIP3 activates AKT signaling

PIP3 activates AKT signaling
metric value
setSize 179
pMANOVA 3.54e-08
p.adjustMANOVA 8.25e-07
s.dist 0.246
s.RNA 0.187
s.meth 0.16
p.RNA 1.81e-05
p.meth 0.00025




Top 20 genes
Gene RNA meth
MAPK1 4560 6099
GRB2 4420 6241
RAC1 4404 5541
IRS2 3955 6152
AGO1 3338 7140
PHC2 4569 4887
VAV1 3798 5834
RRAGA 3206 6806
PSMA7 3130 6903
PSMD4 3947 5314
TGFA 4325 4632
TRIM27 3618 5498
FOXO3 3816 5023
PTEN 3783 4815
PSMA6 2659 6678
PSME3 3326 5232
VAPA 3892 4246
RHEB 2587 6311
PIK3CD 2671 6109
CSNK2A2 2821 5736

Click HERE to show all gene set members

All member genes
RNA meth
AGO1 3338 7140
AGO2 1363 7196
AGO3 384 3465
AKT1 1891 1109
AKT1S1 2817 1894
AKT2 781 5431
ATN1 -1075 3096
BAD 2906 4374
BMI1 -3702 -805
CASP9 4537 3202
CBX4 2029 278
CBX6 2054 3612
CBX8 1089 4611
CDKN1A 2283 2427
CDKN1B -1212 3367
CHD3 -3189 6050
CHD4 -63 640
CHUK 3354 1111
CNOT6L -3217 6262
CREB1 -1458 1422
CSNK2A2 2821 5736
CSNK2B 1983 4743
EED -2862 3088
EGR1 -1170 1893
ERBB2 -2008 4160
ESR2 -3413 4784
EZH2 -920 2695
FGF9 -3638 997
FOXO1 -4458 3034
FOXO3 3816 5023
FRS2 -959 -882
FYN -1686 2793
GATAD2A 2102 189
GATAD2B 1474 5595
GRB2 4420 6241
GSK3A 3876 2534
GSK3B 2685 4908
HBEGF 646 -1007
HDAC1 -207 3287
HDAC2 -1260 5864
HDAC3 1734 7116
HDAC5 903 3068
HDAC7 1275 -487
IER3 2020 1545
IL1RAP 3464 -1122
INSR 3857 3558
IRS1 -2666 4308
IRS2 3955 6152
JUN -400 1283
KDM1A -3046 5493
LAMTOR1 3714 -1589
LAMTOR2 3191 -1342
LAMTOR3 2265 957
LAMTOR4 1751 7000
LAMTOR5 3448 -881
LCK -4408 7246
MAF1 1605 6181
MAPK1 4560 6099
MAPK3 3461 1978
MAPKAP1 1834 5908
MBD3 -2156 6240
MDM2 2338 2095
MKRN1 2433 2197
MLST8 -394 2258
MOV10 -2729 -1882
MTA2 80 5579
MTA3 -3543 5162
MTOR -141 3900
MYD88 4594 1945
NEDD4 3884 -1106
NR4A1 -431 1085
OTUD3 -2861 5747
PDPK1 3218 346
PHC1 -3966 -1213
PHC2 4569 4887
PHC3 -1507 4977
PHLPP1 2261 5441
PHLPP2 -4337 6881
PIK3AP1 4435 1373
PIK3CA 946 1470
PIK3CD 2671 6109
PIK3R1 -3359 6993
PIK3R2 2024 3831
PIK3R3 995 3645
PIP4K2A 790 3045
PIP4K2B -2669 1071
PIP4K2C -716 223
PIP5K1A 1819 4436
PIP5K1C 2641 3895
PML -714 4575
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5A 3674 -230
PPP2R5B 3304 -286
PPP2R5C -1671 7074
PPP2R5D 2123 3470
PPP2R5E -4 1402
PRR5 -2935 -347
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PTEN 3783 4815
PTPN11 2499 5062
RAC1 4404 5541
RAC2 2815 4577
RBBP4 -1544 4061
RCOR1 4284 -178
REST 1134 1286
RHEB 2587 6311
RHOG 4253 3664
RICTOR -2640 2833
RING1 -1660 1003
RNF146 4444 1611
RNF2 368 2513
RPS27A -4269 2589
RPS6KB2 502 4805
RPTOR -1341 5596
RRAGA 3206 6806
RRAGC 1583 5284
RRAGD 3274 -1656
SCMH1 -4153 95
SLC38A9 1908 6117
SRC -2136 -1476
STRN 2310 6485
STUB1 -602 2320
TGFA 4325 4632
THEM4 -4605 809
TNKS -609 4477
TNKS2 924 2960
TNRC6A -777 5197
TNRC6B -251 7059
TP53 -4050 2709
TRAF6 957 -71
TRIB3 207 3767
TRIM27 3618 5498
TSC2 775 3951
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
USP13 -1135 2905
USP7 2187 3259
VAPA 3892 4246
VAV1 3798 5834
WWP2 4309 2916



Transport of small molecules

Transport of small molecules
metric value
setSize 342
pMANOVA 4.64e-08
p.adjustMANOVA 1.06e-06
s.dist 0.186
s.RNA 0.184
s.meth -0.027
p.RNA 6.79e-09
p.meth 0.396




Top 20 genes
Gene RNA meth
TRPM2 4469 -1794
SLC16A3 4572 -1654
ATP6V0A1 4546 -1571
APOBR 3948 -1775
SLC15A4 4272 -1577
SLCO3A1 3855 -1605
SLC6A6 4503 -1368
ATP2A2 3880 -1550
ATP6V1B2 3836 -1555
ATP6V1A 3956 -1497
FTL 4047 -1426
SLC24A4 3468 -1623
STOM 3315 -1586
SLC2A3 4329 -1211
SLC7A5 2267 -1904
TTYH3 4507 -946
SLC4A2 3430 -1098
SLC1A5 2530 -1350
SLC17A5 2173 -1547
ADCY4 3163 -1006

Click HERE to show all gene set members

All member genes
RNA meth
ABCA1 2550 -82
ABCA2 -1241 -1880
ABCA5 -3387 2187
ABCA7 888 5637
ABCB10 4258 6837
ABCB6 -1591 -698
ABCB8 -1079 318
ABCB9 -2912 669
ABCC1 1913 -26
ABCC10 1331 3107
ABCC4 1768 2355
ABCC5 -138 -825
ABCD2 -4385 -1275
ABCD3 932 5775
ABCF1 -1964 5477
ABCG1 -2989 6771
ACO1 -3301 -612
ADCY4 3163 -1006
ADCY7 1818 -981
ADCY9 -666 5439
ADD1 3881 2459
ADD3 1263 4727
AFG3L2 -4004 4870
AHCYL2 -672 4549
AKAP1 -4548 5977
ALAD 4020 1057
ANKH -4374 7272
ANO10 4457 5754
ANO6 1978 1102
ANO7 -2623 3653
ANO8 1562 4602
AP2A1 4623 -316
AP2M1 3567 3723
AP2S1 3281 6039
APOBR 3948 -1775
AQP11 -2408 740
AQP3 -4621 6205
ARL2 -939 244
ARL2BP -3282 2396
ASIC1 -2040 3458
ASPH 4630 2329
ATP10A -2983 6613
ATP10D 1243 -822
ATP11A 4198 132
ATP11B 2964 -241
ATP13A1 -143 3963
ATP13A2 2953 814
ATP1A1 2074 4101
ATP1A3 -775 1092
ATP1B1 -1076 6453
ATP1B3 3149 4129
ATP2A1 -104 5724
ATP2A2 3880 -1550
ATP2A3 577 1877
ATP2B4 2564 4069
ATP2C1 3041 2182
ATP6V0A1 4546 -1571
ATP6V0A2 -2629 6653
ATP6V0B 3723 5503
ATP6V0C 4483 2933
ATP6V0D1 4488 6936
ATP6V0E1 3450 1836
ATP6V0E2 -4253 -1327
ATP6V1A 3956 -1497
ATP6V1B2 3836 -1555
ATP6V1C1 3831 6759
ATP6V1D 4067 1096
ATP6V1E1 3280 4776
ATP6V1F 1531 -699
ATP6V1G2 -4149 3740
ATP6V1H 3287 2559
ATP7B 3043 -580
ATP8A1 -4193 -913
ATP8B2 -4567 4135
ATP8B3 4135 1632
ATP8B4 2620 -1100
ATP9B 3756 -145
BEST4 -2313 245
BMP1 1823 -1739
BSG 4125 205
CALM1 263 4502
CAMK2D -4530 -529
CAMK2G -152 6718
CAND1 -2920 2163
CLCN2 172 -1182
CLCN3 2537 5216
CLCN6 1258 1827
CLCN7 749 4254
CLTA 3106 -546
CLTC 4203 7259
CTNS 4211 5780
CUL1 -4005 -1192
CUTC 2138 5591
CYB5R1 4477 5881
CYB5R4 3609 218
CYB5RL -3461 4315
CYBRD1 1921 -409
DERL1 -2237 363
DERL2 212 -1578
DERL3 -2292 1587
EIF2S1 71 4745
EIF2S2 1496 6254
EMB 3288 6041
ERLEC1 1033 1240
ERLIN1 4317 4339
ERLIN2 4490 786
FBXL5 4033 6720
FLVCR1 461 5191
FTH1 2313 3117
FTL 4047 -1426
FURIN 4429 7181
FXYD7 -3940 -1998
GLRX3 -1909 5241
GNAS 2180 -60
GNB1 4261 2799
GNB2 4032 1879
GNB4 3205 1335
GNB5 -1662 6256
GNG2 1513 6500
GNG3 1124 7142
GNG4 858 6856
GNG5 4379 6512
GNG7 -3064 -499
GNGT2 859 7120
HDLBP 4085 -771
HMOX2 -3777 6413
IREB2 2021 5013
KCNJ11 -1811 -1380
LDLR 3941 1548
LDLRAP1 -4570 4896
LETM1 584 5495
LIPA 1053 2605
LIPG 748 4876
LMF1 -3207 3943
LMF2 -1906 4149
LRRC8A 309 2661
LRRC8B -1309 -1095
LRRC8C -3287 -669
LRRC8D 1320 -21
LSR -4501 6597
MBTPS1 1497 2401
MCOLN1 4251 553
MCOLN2 -1270 -1890
MCU 4335 -190
MICU1 4370 1448
MICU2 925 2099
MRS2 -2025 138
MYLIP -1584 2479
NCEH1 3581 836
NEDD4L 2846 -1080
NEDD8 2980 -105
NIPA1 -1657 -483
NIPA2 2648 4874
NIPAL1 -566 6008
NIPAL2 891 938
NIPAL3 -4419 3874
NPC1 191 5815
NPC2 1910 2198
NR1H2 3489 6463
NR1H3 1154 6206
OS9 4487 -313
OSTM1 3237 4532
P4HB 4143 5718
PARL 3859 4721
PCSK5 2248 -869
PEX19 2842 5854
PEX3 -4348 4637
PHB -2116 4542
PHB2 -1118 3753
PMPCB -3247 1998
PRKACA 4634 890
PRKACB -4510 1712
PRKAR1A 4338 -432
PRKAR1B 1934 1230
PRKAR2A 3132 -874
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
RAB11A 2969 2440
RAF1 3220 6573
RNF185 3066 5002
RNF5 -1369 6758
RPS27A -4269 2589
RUNX1 4116 193
SAR1B 2728 3060
SCARB1 -248 4837
SCNN1A 2002 1693
SEL1L 3003 4058
SGK1 -2329 -1194
SGK3 1321 -733
SKP1 -1442 2680
SLC11A1 4657 4001
SLC11A2 -506 2262
SLC12A2 -4128 1170
SLC12A6 3458 6142
SLC12A7 -1612 -1966
SLC15A4 4272 -1577
SLC16A1 152 5451
SLC16A10 -4555 3241
SLC16A3 4572 -1654
SLC16A7 1944 -898
SLC17A5 2173 -1547
SLC1A4 -743 -1119
SLC1A5 2530 -1350
SLC20A1 -1426 6519
SLC20A2 -2324 6714
SLC22A15 3984 7148
SLC22A4 4311 703
SLC22A5 1948 5708
SLC24A4 3468 -1623
SLC25A22 -2582 5440
SLC25A29 664 2266
SLC25A4 -3766 6752
SLC26A11 -3816 5639
SLC26A2 -233 4122
SLC26A6 4043 2094
SLC27A1 2174 1124
SLC27A4 1697 -934
SLC29A1 3793 5686
SLC29A2 -3945 -775
SLC29A3 2558 4866
SLC29A4 810 869
SLC2A1 -2155 4076
SLC2A11 -2154 726
SLC2A13 1077 528
SLC2A3 4329 -1211
SLC2A9 457 -1831
SLC30A1 2993 2343
SLC30A5 -2090 2443
SLC30A6 91 3630
SLC30A7 -294 1585
SLC31A1 4339 7165
SLC33A1 -660 2774
SLC35A1 1364 3966
SLC35A3 -2221 -802
SLC35B2 -2739 2281
SLC35B3 1177 2334
SLC35B4 2482 1258
SLC35C1 817 5328
SLC35D1 -2406 4366
SLC36A1 4658 412
SLC36A4 3687 -801
SLC38A1 -4087 6812
SLC38A2 508 3094
SLC39A1 4263 -535
SLC39A10 -3118 -1097
SLC39A14 -2851 -1010
SLC39A3 1837 5809
SLC39A4 864 -1513
SLC39A6 -2407 6120
SLC39A8 4392 -435
SLC3A2 2791 744
SLC41A1 -3741 5622
SLC43A1 -1099 1007
SLC43A2 3775 1577
SLC44A1 2845 924
SLC44A2 1805 4323
SLC4A2 3430 -1098
SLC4A7 -3598 6615
SLC50A1 289 -1040
SLC5A3 -3690 2062
SLC5A5 -3595 487
SLC5A6 -2661 6287
SLC5A9 3909 5658
SLC6A6 4503 -1368
SLC6A9 869 2105
SLC7A1 -2302 1098
SLC7A11 142 -895
SLC7A5 2267 -1904
SLC7A6 -3745 6043
SLC8A3 -912 -118
SLC8B1 3250 2339
SLC9A1 4576 1951
SLC9A3 -4078 6474
SLC9A5 -1377 6952
SLC9A8 3686 -95
SLC9B1 -1100 -947
SLC9B2 -3990 -450
SLCO3A1 3855 -1605
SLCO4A1 4506 3119
SLCO4C1 3222 -99
SMDT1 969 7073
SOAT1 2902 364
SPG7 -2416 2073
SRI 3139 -271
STOM 3315 -1586
STOML2 -2127 525
TCIRG1 4397 1353
TFR2 -1651 -1340
TFRC 1670 -131
TPCN1 0 6861
TPCN2 4097 1655
TRPC1 -3897 -631
TRPC4AP 2529 2675
TRPM2 4469 -1794
TRPM7 -1916 3876
TRPV2 1542 877
TTYH2 367 -1612
TTYH3 4507 -946
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
VCP 3034 1908
VDAC1 990 569
VDAC3 236 3667
WNK1 3128 6627
WWP1 -4551 479
YME1L1 2901 3050



Generic Transcription Pathway

Generic Transcription Pathway
metric value
setSize 800
pMANOVA 5.55e-08
p.adjustMANOVA 1.24e-06
s.dist 0.127
s.RNA -0.109
s.meth 0.0652
p.RNA 3.1e-07
p.meth 0.00227




Top 20 genes
Gene RNA meth
RGCC -4492 7232
TCF7 -4620 6951
RORA -4196 6933
ZNF517 -4213 6892
GATA3 -4581 6274
ZNF681 -4297 6567
RPA1 -4364 6282
WRN -4354 6296
NFATC2 -3732 7159
FBXO32 -4013 6488
ZNF563 -4027 6436
ZNF530 -4543 5650
NOP2 -3984 6403
DGCR8 -3639 6998
ZNF75A -3586 7086
ZNF571 -3704 6813
NR1D1 -4199 5907
CTLA4 -3441 7091
EPC1 -3581 6722
ZSCAN25 -3373 7058

Click HERE to show all gene set members

All member genes
RNA meth
ABL1 1975 2469
ACTL6A -3054 -311
AGO1 3338 7140
AGO2 1363 7196
AGO3 384 3465
AKT1 1891 1109
AKT2 781 5431
ANAPC1 -4482 2990
ANAPC10 -418 -1326
ANAPC11 1271 3188
ANAPC15 3233 6483
ANAPC16 -2423 6729
ANAPC2 -2051 2865
ANAPC4 -1105 -687
ANAPC5 -2994 5213
ANAPC7 175 1873
APAF1 3421 -809
ARID1A 3217 1914
ARID1B -300 4017
ARID2 819 1091
ARID3A 3991 2011
ASH2L 3680 3075
ATAD2 -1775 142
ATM -3839 3035
ATR -2449 930
ATRIP -2244 1869
ATXN3 473 2715
AURKA 2658 4012
AURKB 1284 5274
AUTS2 -2047 -1353
AXIN1 -1579 -858
BANP 132 195
BARD1 1240 5972
BAX 1666 1161
BBC3 -682 5286
BCL2L11 3447 5664
BCL6 4540 3669
BID 2614 5466
BIRC5 2356 1965
BLM -1597 5263
BMI1 -3702 -805
BNIP3L 2168 4412
BRCA1 2623 1586
BRD1 -2827 7212
BRD2 -1457 5081
BRD7 -511 3924
BRIP1 -2451 63
BRPF1 -332 5935
BRPF3 -744 3308
BTG1 -1401 5954
BTG2 -2187 5261
CALM1 263 4502
CAMK2D -4530 -529
CAMK2G -152 6718
CAMK4 -4622 2759
CASP1 1192 7031
CASP10 216 -1807
CASP6 -2547 -556
CAT 4134 -1206
CAV1 249 4592
CBFB 863 5862
CBX3 1326 2289
CBX4 2029 278
CBX6 2054 3612
CBX8 1089 4611
CCNA2 256 4428
CCNB1 360 1332
CCNC -2266 4188
CCND1 -2034 1006
CCND2 -4129 -1567
CCND3 4303 4156
CCNE1 -2341 5956
CCNE2 1467 5659
CCNG1 -1620 857
CCNG2 3391 2810
CCNH 645 1260
CCNK 2948 6593
CCNT1 -1783 1761
CDC16 -1889 3340
CDC23 -3699 1597
CDC25C 1516 5507
CDC7 -1873 6399
CDK1 -309 1888
CDK12 1125 5160
CDK13 436 5779
CDK2 -1525 2965
CDK4 -4099 4919
CDK5 4361 3491
CDK5R1 202 7124
CDK6 -2288 562
CDK7 2068 4034
CDK8 795 5795
CDK9 1688 3144
CDKN1A 2283 2427
CDKN1B -1212 3367
CDKN2A -149 3478
CEBPB 4463 337
CENPJ -4058 4073
CHD3 -3189 6050
CHD4 -63 640
CHEK1 -1742 51
CHEK2 -697 5331
CITED2 2991 1266
CITED4 1359 -93
CNOT1 1059 4959
CNOT10 -194 3018
CNOT11 246 3729
CNOT3 1882 3093
CNOT4 702 6001
CNOT6 2546 4653
CNOT6L -3217 6262
CNOT7 -3636 -58
CNOT8 1626 5798
COX11 -4293 2566
COX14 -2107 6534
COX16 -1797 1183
COX19 -1968 47
COX20 -2968 4917
COX4I1 369 6762
COX5A 1733 -152
COX5B 2073 -52
COX6A1 2109 3077
COX6B1 2794 564
COX6C -1077 2304
COX7A2L 2193 5084
COX7C -1240 1883
COX8A 3158 2226
CRADD 1839 1024
CREB1 -1458 1422
CREBBP 2340 892
CSNK2A2 2821 5736
CSNK2B 1983 4743
CTDP1 3594 1002
CTLA4 -3441 7091
CTNNB1 3473 5070
CTSL 4277 3028
CTSV -1816 5170
CUL1 -4005 -1192
CYCS -700 5369
DAXX -1271 1574
DDB2 -147 -1223
DDIT3 1573 5192
DDIT4 2139 3702
DEK 145 6182
DGCR8 -3639 6998
DNA2 -2282 1296
DPY30 533 1423
DYRK2 -4502 4997
E2F1 2365 3145
E2F4 1569 1015
E2F5 -3126 4181
E2F6 -3847 4027
E2F7 -1863 3875
E2F8 462 149
EED -2862 3088
EHMT1 -17 2699
EHMT2 -1503 3889
ELF1 629 -1467
ELF2 2096 978
ELL 2401 1501
EP300 3478 4901
EPC1 -3581 6722
ERBB2 -2008 4160
ERCC2 1784 1849
ERCC3 -87 1487
ESR2 -3413 4784
ESRRA 3561 5421
EXO1 -1138 4438
EZH2 -920 2695
FANCC -1220 1401
FANCD2 -4077 4786
FANCI -2852 1261
FAS 1070 825
FBXO32 -4013 6488
FBXW7 -1004 6667
FKBP5 4561 -681
FOS 692 5647
FOXO1 -4458 3034
FOXO3 3816 5023
FZR1 564 2326
GADD45A 4551 2249
GATA3 -4581 6274
GATAD2A 2102 189
GATAD2B 1474 5595
GLS -4609 2305
GPAM -3807 81
GPI 3145 5674
GPS2 444 6830
GSK3B 2685 4908
GSR 4556 4125
GTF2F1 2455 558
GTF2F2 2495 5307
GTF2H3 -3181 5705
GTF2H4 -953 5240
GTF2H5 613 3417
HDAC1 -207 3287
HDAC10 413 4924
HDAC11 1672 6084
HDAC2 -1260 5864
HDAC3 1734 7116
HDAC4 4304 887
HDAC5 903 3068
HDAC7 1275 -487
HIPK1 3112 4886
HIPK2 4260 7093
HIVEP3 272 6938
HSPD1 -4289 3524
HUS1 311 329
IL2RA -2715 6868
ING2 489 1059
ING5 -4481 4790
ITCH 2362 4854
ITGA4 -3400 -394
ITGA5 3669 3467
ITGAL 761 7038
JMY -3808 5163
JUN -400 1283
JUNB 2048 5018
KAT2A -4179 1343
KAT2B -105 4028
KAT5 1382 1952
KCTD1 1842 2461
KCTD6 2053 -621
KMT2A -3042 7244
KMT2C 1585 6984
KMT2D 2624 6495
KMT2E -36 7066
KRAS 2245 3139
L3MBTL2 -3725 2967
LAMTOR1 3714 -1589
LAMTOR2 3191 -1342
LAMTOR3 2265 957
LAMTOR4 1751 7000
LAMTOR5 3448 -881
LBR 3405 2128
LDB1 -2835 1166
LMO2 3802 2867
LRPPRC -4476 1082
MAF -2162 403
MAML1 2981 1442
MAML2 -3215 4627
MAML3 4174 3460
MAP2K6 4437 4792
MAPK1 4560 6099
MAPK14 4478 2465
MAPK3 3461 1978
MAPKAP1 1834 5908
MAX 313 1615
MBD3 -2156 6240
MDC1 -3376 4410
MDM2 2338 2095
MDM4 -209 5729
MEAF6 -2724 3083
MED1 -534 4473
MED10 -3454 2697
MED13 301 6580
MED15 -879 5803
MED16 1233 -884
MED17 -1374 3538
MED20 3086 180
MED23 -599 3755
MED24 -359 5183
MED25 2513 565
MED26 2289 3021
MED27 -253 1874
MED30 -1116 4136
MED31 -984 2499
MED4 61 127
MED6 -1765 6745
MED7 539 4941
MED8 3196 1234
MEN1 -2694 1903
MGA -2636 -909
MLST8 -394 2258
MNAT1 -1772 1516
MOV10 -2729 -1882
MSH2 -3391 5927
MTA2 80 5579
MTOR -141 3900
MYB -86 -449
NBN 950 4478
NCOR1 3183 -530
NCOR2 4562 -1609
NDRG1 3894 1648
NDUFA4 2065 4279
NEDD4L 2846 -1080
NELFA -1404 3055
NELFB 829 -649
NELFCD -2102 6416
NELFE 2312 1529
NFATC2 -3732 7159
NFE2 4593 -1804
NFYA 699 102
NFYB -4572 1588
NFYC 3999 226
NOP2 -3984 6403
NOTCH1 2941 6291
NOTCH4 3739 4962
NR1D1 -4199 5907
NR1D2 -4379 520
NR1H2 3489 6463
NR1H3 1154 6206
NR2C1 -3321 4894
NR2C2 -1114 7005
NR2C2AP -4317 3955
NR3C1 973 3509
NR3C2 -4466 5083
NR4A1 -431 1085
NR4A2 -870 3570
NR4A3 -1490 1460
NR6A1 3375 -1396
NRBP1 2511 5632
PARP1 -3863 3582
PBRM1 1889 3867
PCBP4 -3309 6284
PCGF5 -3402 1347
PCGF6 -347 2693
PCNA -2610 4383
PDPK1 3218 346
PHC1 -3966 -1213
PHC2 4569 4887
PHC3 -1507 4977
PHF20 -1024 115
PIDD1 -2524 -453
PIN1 -43 4014
PINK1 4082 -715
PIP4K2A 790 3045
PIP4K2B -2669 1071
PIP4K2C -716 223
PLAGL1 1649 -782
PLK2 -304 5974
PLK3 1855 3378
PMAIP1 -4468 -1394
PML -714 4575
PMS2 -1363 5491
POLR2A 2412 4046
POLR2B -903 5563
POLR2C -520 6356
POLR2D -2238 -614
POLR2E 2119 3712
POLR2F 1375 509
POLR2G 1618 1604
POLR2H -2765 6299
POLR2I -1337 5657
POLR2K -1277 3853
PPARD -3709 -791
PPARGC1B 34 1449
PPM1A 3367 -136
PPM1D 2802 2649
PPP1R13B -3525 6430
PPP1R13L -2344 6545
PPP2CA 2861 2598
PPP2CB 3058 2771
PPP2R1B -23 6171
PPP2R5C -1671 7074
PRDM1 -498 1144
PRDX1 1943 510
PRDX2 -1037 2503
PRDX5 3621 4022
PRKAA1 884 607
PRKAB1 2075 -840
PRKAB2 -2556 3091
PRKACA 4634 890
PRKAG1 3050 -1055
PRKAG2 -201 1021
PRKCB 3491 4964
PRKCQ -4282 4208
PRMT1 -3864 2118
PRMT5 159 2005
PRR5 -2935 -347
PSMA1 1896 4759
PSMA2 407 5164
PSMA3 -1936 3586
PSMA5 -2322 3319
PSMA6 2659 6678
PSMA7 3130 6903
PSMB1 -556 5410
PSMB10 -1461 6390
PSMB2 1454 1518
PSMB3 3017 4306
PSMB5 3321 269
PSMB6 2767 5819
PSMB7 3355 4199
PSMB8 -548 5156
PSMB9 -3649 4469
PSMC1 2460 1413
PSMC3 735 736
PSMC4 6 3431
PSMC5 -1355 5095
PSMC6 2162 2356
PSMD1 3359 56
PSMD11 2858 3521
PSMD12 2834 3681
PSMD13 1966 561
PSMD14 1027 6316
PSMD2 3212 3610
PSMD3 1726 5581
PSMD4 3947 5314
PSMD6 2590 2336
PSMD7 1576 2079
PSMD8 2147 4666
PSMD9 3482 3375
PSME1 -3059 1614
PSME2 -3100 778
PSME3 3326 5232
PSME4 -205 5910
PSMF1 2008 7182
PTEN 3783 4815
PTPN1 4210 699
PTPN11 2499 5062
PTPN4 -3841 784
RABGGTA 887 4691
RABGGTB -2900 7207
RAD1 -4521 -31
RAD17 -3871 5343
RAD50 -772 247
RAD51 -352 5267
RAD51D -2892 4330
RAD9A -3139 5967
RAD9B 1832 -246
RARA 4270 2132
RARG -2176 297
RB1 3808 1119
RBBP4 -1544 4061
RBBP5 -425 2829
RBBP8 2859 1329
RBL1 -2744 5256
RBL2 -4334 -479
RBM14 -1287 5599
RBPJ 4163 1033
RBX1 2032 5883
RELA -360 4333
RFC2 2380 4262
RFC3 -4163 2737
RFC4 -4064 5077
RFC5 -3162 4211
RFFL 411 1095
RGCC -4492 7232
RHEB 2587 6311
RHNO1 -2121 511
RICTOR -2640 2833
RING1 -1660 1003
RMI2 120 -1676
RNF111 1846 6049
RNF2 368 2513
RNF34 -780 1414
RORA -4196 6933
RPA1 -4364 6282
RPA3 -3830 2526
RPS27A -4269 2589
RPTOR -1341 5596
RRAGA 3206 6806
RRAGC 1583 5284
RRAGD 3274 -1656
RRM2 -721 4440
RRM2B 1285 1208
RUNX1 4116 193
RUNX2 -4238 2447
RUNX3 -2362 6760
RYBP 2810 6819
SATB2 3691 2932
SCMH1 -4153 95
SCO1 -2632 6273
SCO2 -1799 3284
SESN1 -2060 4661
SESN2 3795 -84
SESN3 -1577 4705
SETD1A -2691 -815
SETD1B 1550 2093
SETD9 -1644 -411
SFN 270 -1779
SGK1 -2329 -1194
SIN3A -2967 3819
SIN3B -18 -419
SIRT1 -2768 6547
SIRT3 -1518 661
SKI -2429 2897
SKIL 2470 3946
SKP1 -1442 2680
SKP2 -1179 1707
SLC2A3 4329 -1211
SLC38A9 1908 6117
SMAD1 4645 206
SMAD2 2413 1865
SMAD3 -3734 -363
SMAD4 -2091 -1925
SMAD6 4249 5259
SMAD7 100 1420
SMARCA2 846 6063
SMARCA4 3223 6792
SMARCB1 -1266 6568
SMARCC1 -1376 2301
SMARCC2 1111 5960
SMARCD1 -2664 -130
SMARCD2 3138 3941
SMARCE1 -583 3183
SMURF1 1871 6934
SMURF2 -2759 3523
SMYD2 -3605 6312
SNW1 1711 2517
SOCS3 4419 6492
SOCS4 -1786 4739
SOD2 2190 6134
SP1 3396 4865
SPI1 4565 -1985
SRC -2136 -1476
SREBF1 387 2475
SSRP1 -4110 770
STAT1 -4254 4970
STK11 -574 750
STUB1 -602 2320
SUMO1 2118 3368
SUPT16H -4222 4839
SUPT4H1 1728 5918
SUPT5H -1710 2020
SURF1 1095 -170
TACO1 -112 -240
TAF10 3677 5288
TAF11 586 882
TAF12 3434 3413
TAF13 3598 3627
TAF15 -1524 4237
TAF2 182 292
TAF3 -1177 1363
TAF4 78 554
TAF4B -3905 4706
TAF5 -2526 3430
TAF6 -417 6843
TAF7 376 455
TAF9 -1869 4396
TBL1XR1 1687 2633
TCEA1 -1750 4154
TCF12 501 -542
TCF3 -2863 -374
TCF7 -4620 6951
TCF7L2 4387 1660
TFAP2E -710 -857
TFDP1 3248 2953
TFDP2 -3389 -1478
TGFA 4325 4632
TGFB1 2241 3769
TGIF1 -2962 -390
TGIF2 -4030 -1905
THRA -1356 761
TIGAR 2481 5175
TMEM219 158 1282
TNFRSF10A -1831 2821
TNFRSF10B 2678 -670
TNFRSF10D 2388 3086
TNKS1BP1 -3529 3401
TNRC6A -777 5197
TNRC6B -251 7059
TOP3A 3871 3073
TOPBP1 -338 3545
TP53 -4050 2709
TP53BP2 3385 -1534
TP53I3 4651 2407
TP53INP1 1949 3584
TP53RK -3679 2847
TPX2 2062 261
TRIAP1 -2165 6160
TRIM28 -3382 3596
TRIM33 21 6680
TSC1 -336 4696
TSC2 775 3951
TTC5 -2227 3420
TXN 3643 -1735
TXNIP -1224 6154
TXNRD1 3917 -1402
UBA52 -1041 -69
UBB 509 5059
UBC 2477 3220
UBE2C 1221 4535
UBE2D1 3774 2741
UBE2D3 3445 3005
UBE2E1 68 2408
UBE2I 14 5796
UBE2S 1470 -706
USP7 2187 3259
VDR 4632 3980
VEGFA 2025 87
WDR5 -824 1100
WRN -4354 6296
WWOX -3828 4712
WWP1 -4551 479
YAF2 -541 -1487
YEATS4 -2911 4457
YES1 -1029 5198
YWHAB 2512 2152
YWHAE 3796 1288
YWHAG 4225 1919
YWHAH 4276 -1276
YWHAQ -1174 3225
YWHAZ 2353 4294
YY1 -1642 1468
ZFHX3 2442 6885
ZFP1 -3811 2171
ZFP14 -2437 5520
ZFP28 -4224 2617
ZFP30 -2814 37
ZFP37 -3535 5350
ZFP90 -2728 4023
ZFPM1 -1229 6831
ZIK1 -4490 1200
ZKSCAN1 1289 3832
ZKSCAN3 -562 -582
ZKSCAN4 39 1247
ZKSCAN5 2836 732
ZKSCAN8 -2980 -1984
ZNF10 -3397 5984
ZNF101 -2712 5649
ZNF136 -4460 1381
ZNF138 -4242 2889
ZNF14 -4303 2143
ZNF140 -3049 5707
ZNF141 -3527 5326
ZNF155 -638 3581
ZNF160 -874 -597
ZNF169 -1606 -198
ZNF17 -3289 4405
ZNF175 -2931 3286
ZNF18 1827 -140
ZNF180 -3554 2630
ZNF184 -3398 2160
ZNF189 609 1728
ZNF19 -1701 -906
ZNF2 -2246 2263
ZNF20 2070 4018
ZNF200 375 5252
ZNF202 -4358 -391
ZNF211 -3878 5488
ZNF212 -3750 1817
ZNF213 3572 2868
ZNF215 1064 -1505
ZNF221 -1236 -1001
ZNF222 -39 3892
ZNF223 -2709 880
ZNF224 -2756 2025
ZNF226 -3419 3324
ZNF227 -2448 808
ZNF23 -3613 -45
ZNF233 -1119 -1823
ZNF234 -2727 6392
ZNF235 -3859 -827
ZNF248 -4256 3065
ZNF25 1150 2002
ZNF250 -2192 720
ZNF253 -3781 5994
ZNF257 -2956 6731
ZNF26 -2554 335
ZNF264 -699 -325
ZNF268 -1788 717
ZNF274 -3242 -269
ZNF282 3235 820
ZNF286A -4356 5052
ZNF287 -4463 867
ZNF3 -3308 3563
ZNF302 -4459 2690
ZNF324 -2314 4648
ZNF324B -1222 3238
ZNF331 -4059 -492
ZNF333 2486 3278
ZNF337 -4361 956
ZNF33A -1982 656
ZNF33B -4604 4399
ZNF34 109 486
ZNF343 -3371 837
ZNF354A 1492 4628
ZNF354C -4283 439
ZNF382 -2356 6294
ZNF394 955 1889
ZNF398 -133 4259
ZNF417 -2874 6888
ZNF418 -2505 -1273
ZNF419 -4071 -1243
ZNF420 -4580 1738
ZNF425 -851 6237
ZNF426 -354 -356
ZNF43 -3728 5317
ZNF430 -3024 -1128
ZNF431 -3773 5327
ZNF432 -3590 4336
ZNF436 -1986 3369
ZNF440 -1763 6886
ZNF443 -188 174
ZNF445 3045 322
ZNF446 -3270 676
ZNF461 -3794 2022
ZNF468 1958 -1501
ZNF470 -3076 5113
ZNF480 -3345 3110
ZNF483 -3330 3488
ZNF484 -2141 -1057
ZNF490 1511 4420
ZNF492 -1542 2700
ZNF496 -2386 2746
ZNF500 -2431 2619
ZNF506 -2878 1927
ZNF517 -4213 6892
ZNF528 -3545 -1161
ZNF529 -3842 6135
ZNF530 -4543 5650
ZNF540 -4173 1989
ZNF546 -1626 4961
ZNF547 -1108 5028
ZNF549 -4538 3573
ZNF550 -3752 -650
ZNF552 2601 3735
ZNF554 -3600 3039
ZNF559 -3597 3388
ZNF561 -1009 3917
ZNF563 -4027 6436
ZNF564 -1424 5905
ZNF566 -4451 2789
ZNF567 -4219 4984
ZNF568 -3858 -177
ZNF569 -2545 1805
ZNF570 -3427 -836
ZNF571 -3704 6813
ZNF573 -2788 1491
ZNF582 -3769 2353
ZNF583 -3911 230
ZNF584 -2372 -1262
ZNF585A -1785 6258
ZNF585B -2287 3175
ZNF587 524 4918
ZNF589 -1083 5516
ZNF596 -2311 -1900
ZNF597 -3281 3305
ZNF600 -2317 -1258
ZNF605 -2130 -1067
ZNF606 -3249 3490
ZNF610 -1519 4541
ZNF611 1000 2480
ZNF613 1473 6560
ZNF614 -3266 6322
ZNF615 -1246 2660
ZNF619 267 -1439
ZNF620 -1833 -1051
ZNF621 -1759 1639
ZNF624 -723 19
ZNF627 -69 268
ZNF641 244 -1172
ZNF655 -596 5619
ZNF664 -3731 1404
ZNF665 -936 3845
ZNF668 823 -545
ZNF670 -1867 -578
ZNF671 -3845 1792
ZNF677 -2918 2486
ZNF678 -3449 3886
ZNF681 -4297 6567
ZNF684 -485 3999
ZNF688 -1209 1886
ZNF689 -1218 2936
ZNF691 -972 2013
ZNF692 -2679 1658
ZNF696 -4038 -563
ZNF70 -2142 399
ZNF700 -466 1456
ZNF701 853 2213
ZNF703 -1281 -229
ZNF706 -2440 -1329
ZNF707 -2825 977
ZNF708 -3198 1382
ZNF709 -2847 6111
ZNF710 4091 -1778
ZNF713 -820 -703
ZNF714 -1027 5273
ZNF717 -1299 566
ZNF736 -3358 6094
ZNF737 -3508 2021
ZNF74 -4171 4957
ZNF740 -3820 5117
ZNF746 3700 512
ZNF747 357 6503
ZNF749 -3932 -1833
ZNF75A -3586 7086
ZNF761 -3556 -599
ZNF764 -1286 6186
ZNF77 -1625 179
ZNF771 -2937 547
ZNF772 -2602 5398
ZNF774 2229 4930
ZNF775 1946 2200
ZNF776 -932 5899
ZNF777 -2233 4582
ZNF778 653 5260
ZNF782 -2599 -705
ZNF785 -2215 1396
ZNF786 -2204 -224
ZNF79 195 2360
ZNF790 -2677 1406
ZNF791 -834 6431
ZNF792 -3169 332
ZNF793 -3584 1232
ZNF799 -2820 3846
ZNF839 791 -1105
ZNF92 -2472 3537
ZSCAN25 -3373 7058



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0                                      
##  [2] GGally_2.0.0                                       
##  [3] ggplot2_3.3.2                                      
##  [4] reshape2_1.4.4                                     
##  [5] gtools_3.8.2                                       
##  [6] tibble_3.0.1                                       
##  [7] dplyr_1.0.0                                        
##  [8] echarts4r_0.3.2                                    
##  [9] mitch_1.0.6                                        
## [10] FlowSorted.Blood.EPIC_1.6.1                        
## [11] ExperimentHub_1.14.0                               
## [12] AnnotationHub_2.20.0                               
## [13] BiocFileCache_1.12.0                               
## [14] dbplyr_1.4.4                                       
## [15] nlme_3.1-148                                       
## [16] quadprog_1.5-8                                     
## [17] genefilter_1.70.0                                  
## [18] topconfects_1.4.0                                  
## [19] gplots_3.0.3                                       
## [20] beeswarm_0.2.3                                     
## [21] IlluminaHumanMethylationEPICmanifest_0.3.0         
## [22] IlluminaHumanMethylationEPICanno.ilm10b2.hg19_0.6.0
## [23] limma_3.44.3                                       
## [24] missMethyl_1.22.0                                  
## [25] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [26] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.0 
## [27] minfi_1.34.0                                       
## [28] bumphunter_1.30.0                                  
## [29] locfit_1.5-9.4                                     
## [30] iterators_1.0.12                                   
## [31] foreach_1.5.0                                      
## [32] Biostrings_2.56.0                                  
## [33] XVector_0.28.0                                     
## [34] SummarizedExperiment_1.18.1                        
## [35] DelayedArray_0.14.0                                
## [36] matrixStats_0.56.0                                 
## [37] Biobase_2.48.0                                     
## [38] GenomicRanges_1.40.0                               
## [39] GenomeInfoDb_1.24.2                                
## [40] IRanges_2.22.2                                     
## [41] S4Vectors_0.26.1                                   
## [42] BiocGenerics_0.34.0                                
## 
## loaded via a namespace (and not attached):
##   [1] backports_1.1.8               plyr_1.8.6                   
##   [3] splines_4.0.2                 BiocParallel_1.22.0          
##   [5] digest_0.6.25                 htmltools_0.5.0              
##   [7] gdata_2.18.0                  magrittr_1.5                 
##   [9] memoise_1.1.0                 readr_1.3.1                  
##  [11] annotate_1.66.0               askpass_1.1                  
##  [13] siggenes_1.62.0               prettyunits_1.1.1            
##  [15] colorspace_1.4-1              blob_1.2.1                   
##  [17] rappdirs_0.3.1                xfun_0.15                    
##  [19] jsonlite_1.7.0                crayon_1.3.4                 
##  [21] RCurl_1.98-1.2                GEOquery_2.56.0              
##  [23] survival_3.2-3                glue_1.4.1                   
##  [25] gtable_0.3.0                  zlibbioc_1.34.0              
##  [27] Rhdf5lib_1.10.0               HDF5Array_1.16.1             
##  [29] scales_1.1.1                  DBI_1.1.0                    
##  [31] rngtools_1.5                  Rcpp_1.0.4.6                 
##  [33] xtable_1.8-4                  progress_1.2.2               
##  [35] bit_1.1-15.2                  mclust_5.4.6                 
##  [37] preprocessCore_1.50.0         htmlwidgets_1.5.1            
##  [39] httr_1.4.1                    RColorBrewer_1.1-2           
##  [41] ellipsis_0.3.1                farver_2.0.3                 
##  [43] pkgconfig_2.0.3               reshape_0.8.8                
##  [45] XML_3.99-0.3                  labeling_0.3                 
##  [47] tidyselect_1.1.0              rlang_0.4.6                  
##  [49] later_1.1.0.1                 AnnotationDbi_1.50.1         
##  [51] pbmcapply_1.5.0               munsell_0.5.0                
##  [53] BiocVersion_3.11.1            tools_4.0.2                  
##  [55] generics_0.0.2                RSQLite_2.2.0                
##  [57] evaluate_0.14                 stringr_1.4.0                
##  [59] fastmap_1.0.1                 yaml_2.2.1                   
##  [61] knitr_1.29                    org.Hs.eg.db_3.11.4          
##  [63] bit64_0.9-7                   beanplot_1.2                 
##  [65] caTools_1.18.0                scrime_1.3.5                 
##  [67] purrr_0.3.4                   doRNG_1.8.2                  
##  [69] mime_0.9                      nor1mix_1.3-0                
##  [71] xml2_1.3.2                    biomaRt_2.44.1               
##  [73] compiler_4.0.2                curl_4.3                     
##  [75] interactiveDisplayBase_1.26.3 testthat_2.3.2               
##  [77] statmod_1.4.34                stringi_1.4.6                
##  [79] highr_0.8                     desc_1.2.0                   
##  [81] GenomicFeatures_1.40.0        lattice_0.20-41              
##  [83] Matrix_1.2-18                 multtest_2.44.0              
##  [85] vctrs_0.3.1                   pillar_1.4.4                 
##  [87] lifecycle_0.2.0               BiocManager_1.30.10          
##  [89] data.table_1.12.8             bitops_1.0-6                 
##  [91] httpuv_1.5.4                  rtracklayer_1.48.0           
##  [93] R6_2.4.1                      promises_1.1.1               
##  [95] gridExtra_2.3                 KernSmooth_2.23-17           
##  [97] codetools_0.2-16              MASS_7.3-51.6                
##  [99] assertthat_0.2.1              rhdf5_2.32.1                 
## [101] rprojroot_1.3-2               openssl_1.4.2                
## [103] withr_2.2.0                   GenomicAlignments_1.24.0     
## [105] Rsamtools_2.4.0               GenomeInfoDbData_1.2.3       
## [107] hms_0.5.3                     grid_4.0.2                   
## [109] tidyr_1.1.0                   base64_2.0                   
## [111] rmarkdown_2.3                 DelayedMatrixStats_1.10.0    
## [113] illuminaio_0.30.0             shiny_1.5.0

END of report